ERBB3 protein expression summary - The Human Protein Atlas

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ERBB3

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HUMAN PROTEIN ATLAS SUMMARYⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Proteinⁱ Full gene name according to HGNC.	Erb-b2 receptor tyrosine kinase 3
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ERBB3 (HER3, LCCS2)
Tissue specificityⁱ ??The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Low tissue specificity
Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestine - Brush border (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal enterocytes, Proximal enterocytes, Oligodendrocytes, Paneth cells)
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed blood cell samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (basophil, neutrophil)
Brain specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category Read more	Low human brain regional specificity
Cancer prognostic summary	Gene product is not prognostic
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular, Membrane, Secreted (different isoforms)
Extracellular locationⁱ All genes with at least one isoform expected to be secreted to the extracellular environment have been annotated and classified either as secreted to blood or as locally secreted, depending on the predicted final location of the corresponding protein. Proteins expected to be locally secreted have been further classified according to their site of expression. Read more	Secreted - unknown location
Subcellular summaryⁱ Describes the main and potential additional location(s) of the encoded protein according to ICC-IF resukt in the Cell Atlas, as well as potential data regarding cell cycle depency (CCD) for the RNA and/or protein expression.	Located in Plasma membrane, Actin filaments
Protein function (UniProt)ⁱ Useful information about the protein provided by UniProt.	Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase 1. May also be activated by CSPG5 2. Involved in the regulation of myeloid cell differentiation 3.... show less
Molecular function (UniProt)ⁱ Keywords assigned by UniProt to proteins due to their particular molecular function.	Kinase, Receptor, Transferase, Tyrosine-protein kinase
Disease involvementⁱ Disease related keywords assigned by UniProt combined with Cancer-related genes and FDA approved drug targets Read more	Cancer-related genes, Disease variant
Ligand (UniProt)ⁱ Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.	ATP-binding, Nucleotide-binding
Gene summary (Entrez)ⁱ Useful information about the gene from Entrez	This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]... show less

TISSUEⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestine - Brush border (mainly)
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Low tissue specificity
Tissue distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Protein expressionⁱ A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation. "Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile. Read more	Cytoplasmic and membranous expression in most tissues.

BRAINⁱ Summary of data presented in the Brain Atlas and a representative image of mRNA expression in the human brain. The image is clickable and will redirect to more Brain Atlas data. The Brain Atlas explores the protein expression in the mammalian brain by visualization and integration of data from three mammalian species (human, pig and mouse). Transcriptomics data combined with affinity-based protein in situ localization down to single cell level is available in a brain-centric sub atlas of the Human Protein Atlas. Read more

Human regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Pig regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Mouse regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity

SINGLE CELL TYPEⁱ Summary of data presented in the Single cell Type section, with an interactive chart showing the cell type-specific mRNA expression. The chart is clickable and will redirect to more Cell Type data. This section contains information about single cell type RNA expression based on scRNAseq of human tissues. The data also covers transcriptomics analysis of human blood and cultured cell lines. Read more

Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal enterocytes, Proximal enterocytes, Oligodendrocytes, Paneth cells)

TISSUE CELL TYPEⁱ

Alveolar cells type 2

Breast glandular cells

Classificationⁱ

Cell type enriched in 2 tissues

PATHOLOGYⁱ Summary of data presented in the Pathology section, with representative images of protein expression in cancer (left) and correlation between mRNA expression and patient survival (right). Images are clickable and redirect to pages with more Pathology data. This section contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Prognostic summary	Gene product is not prognostic
Cancer specificityⁱ Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Read more	Low cancer specificity
Cancer distributionⁱ Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected. Read more	Detected in all

IMMUNE CELLⁱ Summary of data presented in the Immune Cell section and a representative image of mRNA expression in immune cells in the blood. The image is clickable and will redirect to more immune cell related data. The Immune Cell section contains information regarding single cell type mRNA expression profiles of protein-coding genes in various immune cells in the blood, e.g. B-cells and granulocytes. Read more

Immune cell expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Basophils - Unknown function (mainly)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (basophil, neutrophil)

BLOOD PROTEINⁱ Summary of data presented in the Blood proteins section and a representative image of the concentration in plasma and related function for the protein in plasma. The image is clickable and will redirect to more data. The Blood proteins section contains plasma levels of proteins detected in human blood and an analysis of the human secretome (including annotation of the genes predicted to be actively secreted to human blood) is also presented. Read more
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes. Read more	Secreted - unknown location
Detected in blood by immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. Read more	No (not applicable)
Detected in blood by mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	Yes
Detected in blood by proximity extension assayⁱ Detection or not of the gene in blood, based on proximity extension assays (Olink) for a longitudinal wellness study covering 76 individuals with three visits during two years. Read more	Yes

SUBCELLULARⁱ Summary of data presented in the Cell Atlas and a representative image of subcellular localization. The Cell Atlas provides RNA expression data derived from RNA sequencing of a large panel of cell lines and protein localization data derived from antibody-based profiling by immunofluorescence confocal microscopy, using a subset of cell lines selected based on RNA expression. Read more

Main locationⁱ Main subcellular location(s) and reliability score(s) for the encoded protein(s) in human cells. The main location(s) may be characterized by presence in all tested cell lines and/or ihigher staining intensity compared to the potential additional location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Read more	Localized to the Plasma membrane
Additional locationⁱ Additonal subcellular location(s) for the encoded protein(s) in human cells. The additional location(s) may not be present i all cell lines and may have lower staining intensity compared to the main location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Read more	In addition localized to the Actin filaments

CELL LINEⁱ Summary of data presented in the Cell Line section and a representative image of mRNA expression across different human cell lines. The image is clickable and will redirect to more cell line data. This section contains information regarding mRNA expression profiles of human protein-coding genes for a large variety of cell lines. Read more

Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	SK-MEL-30 - Melanocyte processes (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Hep G2, OE19, RT4, SK-BR-3, SK-MEL-30, T-47d, WM-115)
Cell type distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many

METABOLIC

Metabolic info	Present in 1 pathway

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	ERBB3 (HGNC Symbol)
Synonyms	HER3, LCCS2
Description	Erb-b2 receptor tyrosine kinase 3 (HGNC Symbol)
Chromosome	12
Cytoband	q13.2
Chromosome location (bp)	56076799 - 56103505
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11
Protein evidence	Evidence at protein level (all genes)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Ensembl	ENSG00000065361 (version 103.38)
Entrez gene	2065
UniProt	P21860 (UniProt - Evidence at protein level)
neXtProt	NX_P21860
Antibodypedia	ERBB3 antibodies

PROTEIN BROWSERⁱ

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PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ERBB3-201 ENSP00000267101 ENST00000267101	P21860 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Metabolic proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0003197 [endocardial cushion development] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007162 [negative regulation of cell adhesion] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0007422 [peripheral nervous system development] GO:0007507 [heart development] GO:0008284 [positive regulation of cell population proliferation] GO:0009925 [basal plasma membrane] GO:0009968 [negative regulation of signal transduction] GO:0010628 [positive regulation of gene expression] GO:0014037 [Schwann cell differentiation] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0016328 [lateral plasma membrane] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019838 [growth factor binding] GO:0021545 [cranial nerve development] GO:0030296 [protein tyrosine kinase activator activity] GO:0031625 [ubiquitin protein ligase binding] GO:0033674 [positive regulation of kinase activity] GO:0038128 [ERBB2 signaling pathway] GO:0038131 [neuregulin receptor activity] GO:0038132 [neuregulin binding] GO:0038143 [ERBB3:ERBB2 complex] GO:0042060 [wound healing] GO:0042127 [regulation of cell population proliferation] GO:0042802 [identical protein binding] GO:0043125 [ErbB-3 class receptor binding] GO:0043235 [receptor complex] GO:0043524 [negative regulation of neuron apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051048 [negative regulation of secretion] GO:0051402 [neuron apoptotic process] GO:0051897 [positive regulation of protein kinase B signaling] GO:0055025 [positive regulation of cardiac muscle tissue development] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000145 [regulation of cell motility] Show all	1342 aa 148.1 kDa	Yes	1
ERBB3-202 ENSP00000415753 ENST00000411731	P21860 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Metabolic proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0004672 [protein kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007162 [negative regulation of cell adhesion] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0007422 [peripheral nervous system development] GO:0007507 [heart development] GO:0008284 [positive regulation of cell population proliferation] GO:0009925 [basal plasma membrane] GO:0009968 [negative regulation of signal transduction] GO:0014037 [Schwann cell differentiation] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016323 [basolateral plasma membrane] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019838 [growth factor binding] GO:0021545 [cranial nerve development] GO:0030296 [protein tyrosine kinase activator activity] GO:0031625 [ubiquitin protein ligase binding] GO:0033674 [positive regulation of kinase activity] GO:0038128 [ERBB2 signaling pathway] GO:0038131 [neuregulin receptor activity] GO:0038132 [neuregulin binding] GO:0038143 [ERBB3:ERBB2 complex] GO:0042060 [wound healing] GO:0042127 [regulation of cell population proliferation] GO:0042802 [identical protein binding] GO:0043125 [ErbB-3 class receptor binding] GO:0043235 [receptor complex] GO:0043524 [negative regulation of neuron apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051048 [negative regulation of secretion] GO:0051402 [neuron apoptotic process] GO:0051897 [positive regulation of protein kinase B signaling] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000145 [regulation of cell motility] Show all	183 aa 20.1 kDa	Yes	0
ERBB3-203 ENSP00000408340 ENST00000415288	P21860 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Metabolic proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007162 [negative regulation of cell adhesion] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0007422 [peripheral nervous system development] GO:0007507 [heart development] GO:0008284 [positive regulation of cell population proliferation] GO:0009925 [basal plasma membrane] GO:0009968 [negative regulation of signal transduction] GO:0014037 [Schwann cell differentiation] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016323 [basolateral plasma membrane] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019838 [growth factor binding] GO:0021545 [cranial nerve development] GO:0030296 [protein tyrosine kinase activator activity] GO:0031625 [ubiquitin protein ligase binding] GO:0033674 [positive regulation of kinase activity] GO:0038128 [ERBB2 signaling pathway] GO:0038131 [neuregulin receptor activity] GO:0038132 [neuregulin binding] GO:0038143 [ERBB3:ERBB2 complex] GO:0042060 [wound healing] GO:0042127 [regulation of cell population proliferation] GO:0042802 [identical protein binding] GO:0043125 [ErbB-3 class receptor binding] GO:0043235 [receptor complex] GO:0043524 [negative regulation of neuron apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051048 [negative regulation of secretion] GO:0051402 [neuron apoptotic process] GO:0051897 [positive regulation of protein kinase B signaling] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000145 [regulation of cell motility] Show all	1283 aa 141.8 kDa	No	1
ERBB3-207 ENSP00000449138 ENST00000549061	F8VW48 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Diabetes Protein evidence (Ezkurdia et al 2014) Show all		116 aa 13.3 kDa	No	0
ERBB3-209 ENSP00000448636 ENST00000549282	F8VRL0 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Metabolic proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Diabetes Protein evidence (Ezkurdia et al 2014) Show all		126 aa 14 kDa	Yes	0
ERBB3-212 ENSP00000449713 ENST00000549672	F8VX90 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Diabetes Protein evidence (Ezkurdia et al 2014) Show all		115 aa 13.2 kDa	No	0
ERBB3-213 ENSP00000448729 ENST00000549832	B3KWG5 [Direct mapping] Receptor tyrosine-protein kinase erbB-3; cDNA FLJ43038 fis, clone BRTHA3002955, highly similar to Receptor tyrosine-protein kinase erbB-3 Show all	Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Diabetes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0006468 [protein phosphorylation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	462 aa 50.7 kDa	No	0
ERBB3-214 ENSP00000448946 ENST00000550070	F8VYK4 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Metabolic proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Diabetes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0006468 [protein phosphorylation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	649 aa 71.6 kDa	No	1
ERBB3-215 ENSP00000482073 ENST00000550828	O75812 [Direct mapping] ErbB-3 R31; Receptor tyrosine-protein kinase erbB-3 Show all	Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Diabetes Protein evidence (Ezkurdia et al 2014) Show all		81 aa 8.5 kDa	No	0
ERBB3-221 ENSP00000449129 ENST00000553131	F8VW56 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Diabetes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	583 aa 64.3 kDa	No	0
ERBB3-222 ENSP00000495453 ENST00000643266	A0A2R8Y6T4 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Diabetes Protein evidence (Ezkurdia et al 2014) Show all		19 aa 2.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.