The Metabolic Atlas portion of the Tissue Atlas enables exploration of protein function and tissue-specific gene expression in the context of the human metabolic network. For proteins involved in metabolism, a metabolic summary is provided that describes the metabolic subsystems/pathways, cellular compartments, and number of reactions associated with each protein. Over 120 manually curated metabolic pathway maps facilitate the visualization of each protein’s participation in different metabolic processes.

Key publication

• Robinson JL et al., An atlas of human metabolism. Sci Signal. (2020)
  PubMed: 32209698 DOI: 10.1126/scisignal.aaz1482

Other selected publications

• Mardinoglu A et al., Integration of clinical data with a genome-scale metabolic model of the human adipocyte. Mol Syst Biol. (2013)
  PubMed: 23511207 DOI: 10.1038/msb.2013.5

• Gatto F et al., Chromosome 3p loss of heterozygosity is associated with a unique metabolic network in clear cell renal carcinoma. Proc Natl Acad Sci U S A. (2014)
  PubMed: 24550497 DOI: 10.1073/pnas.1319196111

• Mardinoglu A et al., Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease. Nat Commun. (2014)
  PubMed: 24419221 DOI: 10.1038/ncomms4083

• Agren R et al., Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol. (2014)
  PubMed: 24646661