Endocrine pancreas is the new addition to the exploration of protein expression with multiplex immunohistochemistry (mIHC/IF). Cell-specific markers, including insulin (gene: INS), are utilized to map the various endocrine cell types.

In the latest version 25 of the Human Protein Atlas, the mIHC/IF-based exploration of protein expression has expanded to include the various specialized endocrine cell types of the pancreas. The pancreas panel includes five markers, made up of five different endocrine peptide hormones that are specifically expressed and secreted by separate cell types within the islets of Langerhans.

The marker for beta cells and the well-known blood glucose-level regulating hormone, insulin, shows localization (green) in major areas of the interior part of the islets of Langerhans. Other visualized cell types include alpha cells (cyan), mainly localized in the outer parts of the islets, and a small number of delta cells (yellow).

For more details about the mIHC/IF technique visit our method page.