2025 was a year of intensified global conflicts, political instability and climate extremes, but also the year when renewable energy became a larger energy source than coal, the first gene therapy for Huntington's disease showed remarkable results, the first malaria treatment for infants was approved by WHO and the green sea turtle bounced back from near extinction. From the HPA perspective it was an interesting and fruitful year from which we will share some of the highlights.

In November a new version 25 of the open-access Human Protein Atlas resource was published at the HUPO World Congress in Toronto. The updated Atlas expands the Blood resource to contain pan-disease blood profiling data for in total 71 diseases, including Olink Explore HT and SomaScan data across 32 cohorts. The addition of new tissues resulted in the Single cell resource now comprising 154 different cell types, thus representing the majority of the cell types found in the human body. Predicted structures for 23000 protein-protein interactions was also introduced.

A lot of focus has been around the development of AI, and in May the HPA director Mathias Uhlén was interviewed in GenomeWeb regarding the new Alpha Cell project, an effort funded by the Knut and Alice Wallenberg Foundation with the aim to combine AI and existing data to generate three-dimensional cell models to map and track cellular components and processes over time.

During the year HPA reached 1000 published peer-reviewed articles including "A human pan-disease blood atlas of the circulating proteome" in Science, "Intrinsic heterogeneity of primary cilia revealed through spatial proteomics." in Cell, "Multimodal cell maps as a foundation for structural and functional genomics." in Nature, and "Single-cell spatial transcriptomic atlas of the whole mouse brain" in Neuron.

We are grateful for all feedback from the scientific community and for the continuously growing interest in the Human Protein Atlas reflected by the around 500 000 monthly visits and the about 3000 publications citing us last year.

The HPA consortium wishes all of you an exciting and productive 2026 in the field of protein science.