Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific nTPM" "RNA single cell type specificity" "RNA single cell type distribution" "RNA single cell type specificity score" "RNA single cell type specific nTPM" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific nTPM" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific nTPM" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific nTPM" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific nTPM" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific nTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific nTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "CCD Protein" "CCD Transcript" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Blood expression cluster" "Tissue expression cluster" "Cell line expression cluster" "Single cell expression cluster" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [nTPM]" "Tissue RNA - adrenal gland [nTPM]" "Tissue RNA - amygdala [nTPM]" "Tissue RNA - appendix [nTPM]" "Tissue RNA - basal ganglia [nTPM]" "Tissue RNA - bone marrow [nTPM]" "Tissue RNA - breast [nTPM]" "Tissue RNA - cerebellum [nTPM]" "Tissue RNA - cerebral cortex [nTPM]" "Tissue RNA - cervix [nTPM]" "Tissue RNA - choroid plexus [nTPM]" "Tissue RNA - colon [nTPM]" "Tissue RNA - duodenum [nTPM]" "Tissue RNA - endometrium 1 [nTPM]" "Tissue RNA - epididymis [nTPM]" "Tissue RNA - esophagus [nTPM]" "Tissue RNA - fallopian tube [nTPM]" "Tissue RNA - gallbladder [nTPM]" "Tissue RNA - heart muscle [nTPM]" "Tissue RNA - hippocampal formation [nTPM]" "Tissue RNA - hypothalamus [nTPM]" "Tissue RNA - kidney [nTPM]" "Tissue RNA - liver [nTPM]" "Tissue RNA - lung [nTPM]" "Tissue RNA - lymph node [nTPM]" "Tissue RNA - medulla oblongata [nTPM]" "Tissue RNA - midbrain [nTPM]" "Tissue RNA - ovary [nTPM]" "Tissue RNA - pancreas [nTPM]" "Tissue RNA - parathyroid gland [nTPM]" "Tissue RNA - pituitary gland [nTPM]" "Tissue RNA - placenta [nTPM]" "Tissue RNA - pons [nTPM]" "Tissue RNA - prostate [nTPM]" "Tissue RNA - rectum [nTPM]" "Tissue RNA - retina [nTPM]" "Tissue RNA - salivary gland [nTPM]" "Tissue RNA - seminal vesicle [nTPM]" "Tissue RNA - skeletal muscle [nTPM]" "Tissue RNA - skin 1 [nTPM]" "Tissue RNA - small intestine [nTPM]" "Tissue RNA - smooth muscle [nTPM]" "Tissue RNA - spinal cord [nTPM]" "Tissue RNA - spleen [nTPM]" "Tissue RNA - stomach 1 [nTPM]" "Tissue RNA - testis [nTPM]" "Tissue RNA - thalamus [nTPM]" "Tissue RNA - thymus [nTPM]" "Tissue RNA - thyroid gland [nTPM]" "Tissue RNA - tongue [nTPM]" "Tissue RNA - tonsil [nTPM]" "Tissue RNA - urinary bladder [nTPM]" "Tissue RNA - vagina [nTPM]" "Tissue RNA - white matter [nTPM]" "Cell RNA - A-431 [nTPM]" "Cell RNA - A549 [nTPM]" "Cell RNA - AF22 [nTPM]" "Cell RNA - AN3-CA [nTPM]" "Cell RNA - ASC diff [nTPM]" "Cell RNA - ASC TERT1 [nTPM]" "Cell RNA - BEWO [nTPM]" "Cell RNA - BJ [nTPM]" "Cell RNA - BJ hTERT+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]" "Cell RNA - CACO-2 [nTPM]" "Cell RNA - CAPAN-2 [nTPM]" "Cell RNA - Daudi [nTPM]" "Cell RNA - EFO-21 [nTPM]" "Cell RNA - fHDF/TERT166 [nTPM]" "Cell RNA - GAMG [nTPM]" "Cell RNA - HaCaT [nTPM]" "Cell RNA - HAP1 [nTPM]" "Cell RNA - HBEC3-KT [nTPM]" "Cell RNA - HBF TERT88 [nTPM]" "Cell RNA - HDLM-2 [nTPM]" "Cell RNA - HEK 293 [nTPM]" "Cell RNA - HEL [nTPM]" "Cell RNA - HeLa [nTPM]" "Cell RNA - Hep G2 [nTPM]" "Cell RNA - HHSteC [nTPM]" "Cell RNA - HL-60 [nTPM]" "Cell RNA - HMC-1 [nTPM]" "Cell RNA - HSkMC [nTPM]" "Cell RNA - hTCEpi [nTPM]" "Cell RNA - hTEC/SVTERT24-B [nTPM]" "Cell RNA - hTERT-HME1 [nTPM]" "Cell RNA - hTERT-RPE1 [nTPM]" "Cell RNA - HUVEC TERT2 [nTPM]" "Cell RNA - JURKAT [nTPM]" "Cell RNA - K-562 [nTPM]" "Cell RNA - Karpas-707 [nTPM]" "Cell RNA - LHCN-M2 [nTPM]" "Cell RNA - MCF7 [nTPM]" "Cell RNA - MOLT-4 [nTPM]" "Cell RNA - NB-4 [nTPM]" "Cell RNA - NTERA-2 [nTPM]" "Cell RNA - OE19 [nTPM]" "Cell RNA - PC-3 [nTPM]" "Cell RNA - REH [nTPM]" "Cell RNA - RH-30 [nTPM]" "Cell RNA - RPMI-8226 [nTPM]" "Cell RNA - RPTEC TERT1 [nTPM]" "Cell RNA - RT4 [nTPM]" "Cell RNA - SCLC-21H [nTPM]" "Cell RNA - SH-SY5Y [nTPM]" "Cell RNA - SiHa [nTPM]" "Cell RNA - SK-BR-3 [nTPM]" "Cell RNA - SK-MEL-30 [nTPM]" "Cell RNA - SuSa [nTPM]" "Cell RNA - T-47d [nTPM]" "Cell RNA - THP-1 [nTPM]" "Cell RNA - TIME [nTPM]" "Cell RNA - U-138 MG [nTPM]" "Cell RNA - U-2 OS [nTPM]" "Cell RNA - U-2197 [nTPM]" "Cell RNA - U-251 MG [nTPM]" "Cell RNA - U-266/70 [nTPM]" "Cell RNA - U-266/84 [nTPM]" "Cell RNA - U-698 [nTPM]" "Cell RNA - U-87 MG [nTPM]" "Cell RNA - U-937 [nTPM]" "Cell RNA - WM-115 [nTPM]" "Blood RNA - basophil [nTPM]" "Blood RNA - classical monocyte [nTPM]" "Blood RNA - eosinophil [nTPM]" "Blood RNA - gdT-cell [nTPM]" "Blood RNA - intermediate monocyte [nTPM]" "Blood RNA - MAIT T-cell [nTPM]" "Blood RNA - memory B-cell [nTPM]" "Blood RNA - memory CD4 T-cell [nTPM]" "Blood RNA - memory CD8 T-cell [nTPM]" "Blood RNA - myeloid DC [nTPM]" "Blood RNA - naive B-cell [nTPM]" "Blood RNA - naive CD4 T-cell [nTPM]" "Blood RNA - naive CD8 T-cell [nTPM]" "Blood RNA - neutrophil [nTPM]" "Blood RNA - NK-cell [nTPM]" "Blood RNA - non-classical monocyte [nTPM]" "Blood RNA - plasmacytoid DC [nTPM]" "Blood RNA - T-reg [nTPM]" "Blood RNA - total PBMC [nTPM]" "Brain RNA - amygdala [nTPM]" "Brain RNA - basal ganglia [nTPM]" "Brain RNA - cerebellum [nTPM]" "Brain RNA - cerebral cortex [nTPM]" "Brain RNA - hippocampal formation [nTPM]" "Brain RNA - hypothalamus [nTPM]" "Brain RNA - medulla oblongata [nTPM]" "Brain RNA - midbrain [nTPM]" "Brain RNA - pons [nTPM]" "Brain RNA - spinal cord [nTPM]" "Brain RNA - thalamus [nTPM]" "Brain RNA - white matter [nTPM]" "Single Cell Type RNA - Adipocytes [nTPM]" "Single Cell Type RNA - Alveolar cells type 1 [nTPM]" "Single Cell Type RNA - Alveolar cells type 2 [nTPM]" "Single Cell Type RNA - Astrocytes [nTPM]" "Single Cell Type RNA - B-cells [nTPM]" "Single Cell Type RNA - Basal keratinocytes [nTPM]" "Single Cell Type RNA - Basal prostatic cells [nTPM]" "Single Cell Type RNA - Basal respiratory cells [nTPM]" "Single Cell Type RNA - Basal squamous epithelial cells [nTPM]" "Single Cell Type RNA - Bipolar cells [nTPM]" "Single Cell Type RNA - Breast glandular cells [nTPM]" "Single Cell Type RNA - Breast myoepithelial cells [nTPM]" "Single Cell Type RNA - Cardiomyocytes [nTPM]" "Single Cell Type RNA - Cholangiocytes [nTPM]" "Single Cell Type RNA - Club cells [nTPM]" "Single Cell Type RNA - Collecting duct cells [nTPM]" "Single Cell Type RNA - Cone photoreceptor cells [nTPM]" "Single Cell Type RNA - Cytotrophoblasts [nTPM]" "Single Cell Type RNA - dendritic cells [nTPM]" "Single Cell Type RNA - Distal enterocytes [nTPM]" "Single Cell Type RNA - Distal tubular cells [nTPM]" "Single Cell Type RNA - Ductal cells [nTPM]" "Single Cell Type RNA - Early spermatids [nTPM]" "Single Cell Type RNA - Endometrial ciliated cells [nTPM]" "Single Cell Type RNA - Endometrial stromal cells [nTPM]" "Single Cell Type RNA - Endothelial cells [nTPM]" "Single Cell Type RNA - Enteroendocrine cells [nTPM]" "Single Cell Type RNA - Erythroid cells [nTPM]" "Single Cell Type RNA - Excitatory neurons [nTPM]" "Single Cell Type RNA - Exocrine glandular cells [nTPM]" "Single Cell Type RNA - Extravillous trophoblasts [nTPM]" "Single Cell Type RNA - Fibroblasts [nTPM]" "Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]" "Single Cell Type RNA - Glandular and luminal cells [nTPM]" "Single Cell Type RNA - granulocytes [nTPM]" "Single Cell Type RNA - Granulosa cells [nTPM]" "Single Cell Type RNA - Hepatic stellate cells [nTPM]" "Single Cell Type RNA - Hepatocytes [nTPM]" "Single Cell Type RNA - Hofbauer cells [nTPM]" "Single Cell Type RNA - Horizontal cells [nTPM]" "Single Cell Type RNA - Inhibitory neurons [nTPM]" "Single Cell Type RNA - Intestinal goblet cells [nTPM]" "Single Cell Type RNA - Ionocytes [nTPM]" "Single Cell Type RNA - Kupffer cells [nTPM]" "Single Cell Type RNA - Langerhans cells [nTPM]" "Single Cell Type RNA - Late spermatids [nTPM]" "Single Cell Type RNA - Leydig cells [nTPM]" "Single Cell Type RNA - Macrophages [nTPM]" "Single Cell Type RNA - Melanocytes [nTPM]" "Single Cell Type RNA - Microglial cells [nTPM]" "Single Cell Type RNA - monocytes [nTPM]" "Single Cell Type RNA - Muller glia cells [nTPM]" "Single Cell Type RNA - NK-cells [nTPM]" "Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]" "Single Cell Type RNA - Oligodendrocytes [nTPM]" "Single Cell Type RNA - Pancreatic endocrine cells [nTPM]" "Single Cell Type RNA - Paneth cells [nTPM]" "Single Cell Type RNA - Peritubular cells [nTPM]" "Single Cell Type RNA - Plasma cells [nTPM]" "Single Cell Type RNA - Prostatic glandular cells [nTPM]" "Single Cell Type RNA - Proximal enterocytes [nTPM]" "Single Cell Type RNA - Proximal tubular cells [nTPM]" "Single Cell Type RNA - Respiratory ciliated cells [nTPM]" "Single Cell Type RNA - Rod photoreceptor cells [nTPM]" "Single Cell Type RNA - Sertoli cells [nTPM]" "Single Cell Type RNA - Skeletal myocytes [nTPM]" "Single Cell Type RNA - Smooth muscle cells [nTPM]" "Single Cell Type RNA - Spermatocytes [nTPM]" "Single Cell Type RNA - Spermatogonia [nTPM]" "Single Cell Type RNA - Squamous epithelial cells [nTPM]" "Single Cell Type RNA - Suprabasal keratinocytes [nTPM]" "Single Cell Type RNA - Syncytiotrophoblasts [nTPM]" "Single Cell Type RNA - T-cells [nTPM]" "Single Cell Type RNA - Theca cells [nTPM]" "Single Cell Type RNA - Undifferentiated cells [nTPM]" "Single Cell Type RNA - Urothelial cells [nTPM]" AACS "ACSF1, FLJ12389, SUR-5" ENSG00000081760 "Acetoacetyl-CoA synthetase" Q86V21 12 125065434-125143333 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Fatty acid metabolism, Lipid metabolism" Ligase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 67.1;Excitatory neurons: 59.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA058815 Approved Approved Vesicles NA NA "Cluster 44: Non-specific - Transcription" "Cluster 31: Skin - Epidermis development" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 29: Early spermatids - Spermatogenesis" Vesicles "HPA058815: AB_2683826" "unprognostic (1.28e-1)" "unprognostic (9.78e-2)" "unprognostic (1.86e-1)" "unprognostic (1.06e-1)" "unprognostic (1.98e-3)" "unprognostic (9.46e-3)" "unprognostic (6.60e-6)" "unprognostic (3.03e-2)" "unprognostic (3.32e-2)" "unprognostic (2.45e-2)" "unprognostic (2.38e-2)" "unprognostic (3.04e-1)" "unprognostic (2.69e-2)" "unprognostic (1.69e-1)" "unprognostic (3.73e-2)" "unprognostic (7.71e-2)" "unprognostic (6.80e-2)" 31.7 7.8 6.4 5.6 8.2 3.7 43.4 2.8 11.0 14.6 3.2 12.7 17.9 6.3 8.7 30.9 8.5 7.6 7.4 9.1 3.7 10.3 3.9 6.2 5.8 6.1 3.1 6.0 12.8 9.6 8.5 6.1 6.0 8.6 11.3 6.2 48.2 7.5 5.5 40.4 10.4 5.8 2.4 5.2 16.9 13.5 5.0 10.4 10.0 7.6 10.2 6.1 14.3 6.5 26.8 26.2 11.2 15.3 40.3 26.1 18.7 21.2 20.1 24.6 21.8 34.0 17.4 16.5 21.3 25.7 10.6 28.4 21.0 22.8 13.2 17.8 19.2 13.1 16.9 26.2 33.5 9.4 12.8 29.1 18.2 21.0 21.0 30.8 18.1 9.5 9.4 9.9 15.9 49.1 10.8 12.7 14.2 28.0 30.4 2.1 28.2 23.0 25.0 40.2 29.7 8.6 22.4 35.0 16.6 10.8 26.2 20.7 17.4 11.8 18.7 13.4 16.4 22.0 13.6 18.0 14.8 15.4 13.2 7.7 2.1 5.9 3.3 0.6 4.4 2.4 3.1 2.5 2.4 1.2 4.4 3.0 0.3 5.4 0.7 9.9 2.1 3.4 6.4 8.2 2.8 11.0 9.1 3.7 6.1 3.1 6.0 2.4 5.0 6.5 4.2 6.4 17.3 16.3 4.5 16.6 5.6 14.1 9.1 20.9 23.6 16.9 9.4 17.2 12.0 5.5 27.1 2.1 6.5 14.0 7.9 11.0 67.1 6.3 15.3 6.5 25.2 0.8 59.4 10.7 8.7 11.8 13.3 12.3 2.5 13.1 2.2 4.2 4.8 6.7 28.6 22.0 16.2 4.1 9.0 22.5 9.3 3.9 5.4 5.6 5.4 5.6 5.2 12.1 12.5 9.9 7.4 5.3 12.1 8.2 10.7 6.5 5.7 21.8 0.0 8.6 7.7 22.0 5.3 25.3 28.1 2.5 8.1 20.8 15.8 5.6 ACAT2 ENSG00000120437 "Acetyl-CoA acetyltransferase 2" Q9BWD1 6 159762045-159779112 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 6 "liver: 231.3" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 262.1;Early spermatids: 187.0;Exocrine glandular cells: 176.6;Hepatocytes: 214.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB021106, HPA025736, HPA025765, HPA025811" Enhanced Approved Nucleoplasm,Cytosol NA NA 14000000 "Cluster 44: Non-specific - Transcription" "Cluster 85: Liver - Metabolism" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Cytosol Nucleoplasm "CAB021106: AB_10058215, HPA025736: AB_1844487, HPA025765: AB_1844485, HPA025811: AB_1844488" "unprognostic (3.31e-1)" "unprognostic (2.44e-2)" "prognostic favorable (1.12e-4)" "prognostic unfavorable (7.25e-4)" "unprognostic (1.38e-1)" "unprognostic (2.03e-1)" "unprognostic (9.25e-2)" "unprognostic (4.76e-2)" "unprognostic (1.43e-1)" "unprognostic (2.58e-1)" "unprognostic (1.21e-1)" "unprognostic (1.59e-1)" "prognostic unfavorable (7.38e-4)" "unprognostic (1.39e-1)" "unprognostic (1.50e-2)" "unprognostic (8.56e-2)" "unprognostic (2.54e-2)" 10.9 21.6 22.2 18.5 24.4 22.4 23.6 30.2 30.0 12.8 20.1 38.5 31.2 10.9 40.0 32.6 11.4 10.6 9.4 22.7 27.6 27.0 231.3 20.2 25.0 39.4 26.3 17.3 9.4 12.5 3.2 11.8 39.1 35.6 33.8 19.5 15.5 9.3 4.9 18.1 17.9 15.8 24.8 9.7 19.5 28.6 24.4 39.4 9.0 7.1 36.7 13.7 9.1 28.1 70.1 58.8 451.9 160.8 57.2 111.6 14.4 57.4 70.5 141.8 244.5 234.0 87.1 55.9 29.0 48.7 458.2 64.5 174.8 465.8 166.7 35.2 174.4 127.4 97.2 418.8 62.0 81.4 35.8 62.2 40.1 231.1 92.9 21.4 68.8 160.1 139.9 104.3 85.5 113.0 137.0 154.0 142.8 65.5 41.7 83.9 94.4 173.1 377.2 93.7 107.8 63.2 67.5 43.3 26.2 18.5 83.4 157.3 39.2 50.3 45.7 72.1 154.0 47.7 89.0 142.0 15.7 151.2 77.1 30.1 24.9 46.7 47.9 33.9 47.3 46.6 54.1 47.8 34.7 51.4 53.3 43.2 11.0 41.3 23.6 30.4 79.0 46.2 22.2 24.4 30.2 30.0 22.7 27.6 39.4 26.3 39.1 24.8 24.4 28.1 11.8 12.8 45.4 15.3 25.8 26.1 32.4 262.1 22.2 19.4 33.4 24.5 1.2 42.9 115.5 20.2 2.1 53.7 28.6 34.7 70.5 78.8 187.0 14.3 9.9 18.8 17.2 38.5 14.3 176.6 97.0 21.6 9.7 25.9 13.3 47.7 16.1 214.8 58.1 13.5 14.7 23.6 83.4 14.8 29.8 128.8 13.7 25.7 30.2 1.0 58.9 22.5 30.9 13.0 17.5 65.6 28.8 19.2 25.5 38.7 15.4 50.0 30.1 24.7 0.0 25.1 44.9 28.5 45.6 43.0 21.0 35.2 31.0 102.5 33.0 38.9 CEL "BSSL, MODY8" ENSG00000170835 "Carboxyl ester lipase" P19835 9 133061981-133071861 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted secreted proteins" "Lipid degradation, Lipid metabolism" "Hydrolase, Serine esterase" "Diabetes mellitus" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 548 "pancreas: 110578.0" "Group enriched" "Detected in many" 10 "Breast glandular cells: 390.7;Exocrine glandular cells: 943.6" "Cancer enriched" "Detected in many" 29 "pancreatic cancer: 469.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "JURKAT: 7.5" "Not detected" "Not detected" "Not detected" "Not detected" "HPA008023, HPA052701" Enhanced "Secreted to digestive system" NA NA 110000 "Cluster 25: Pancreas - Digestion" "Cluster 3: HMC-1 - Innate immune response" "Cluster 30: Mammary glandular cells - Lactation" "HPA008023: AB_1846509, HPA052701: AB_2681921" "prognostic unfavorable (4.14e-4)" "unprognostic (2.30e-2)" "unprognostic (4.49e-2)" "unprognostic (3.14e-2)" "unprognostic (2.22e-1)" "unprognostic (2.48e-1)" "unprognostic (1.49e-1)" "unprognostic (6.27e-2)" "unprognostic (3.04e-2)" "unprognostic (1.47e-2)" "unprognostic (2.51e-1)" "unprognostic (5.55e-2)" "unprognostic (2.26e-3)" "unprognostic (2.98e-1)" "unprognostic (4.41e-1)" "unprognostic (4.37e-2)" "unprognostic (1.02e-1)" 10.0 3.0 3.1 2.2 3.2 0.9 10.4 4.8 4.5 6.4 13.5 2.9 21.6 3.2 200.8 7.1 11.1 0.4 22.0 4.1 2.7 7.5 6.4 2.1 4.1 2.9 2.8 57.2 110578.0 0.3 201.7 7.1 3.0 5.1 1.3 1.1 19.9 3.3 2.2 5.5 9.2 0.5 2.5 3.4 18.5 2.5 3.0 1.9 2.5 0.4 0.6 3.4 3.4 3.0 0.3 0.8 3.1 1.9 1.0 0.7 3.1 0.6 0.3 0.4 0.6 0.9 0.6 0.9 1.5 0.6 0.5 2.2 0.7 5.9 0.2 1.9 1.2 1.6 0.5 2.1 0.4 0.7 5.9 1.5 3.8 0.5 0.3 1.3 0.6 7.5 1.0 0.8 0.5 1.3 0.9 3.2 5.2 0.7 1.0 1.8 0.9 0.7 0.4 2.7 5.3 1.3 0.7 0.7 0.3 4.5 1.0 2.9 0.4 1.5 2.0 1.7 0.4 0.4 3.4 0.7 0.0 1.6 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.1 3.2 4.8 4.5 4.1 2.7 2.9 2.8 3.0 2.5 3.0 3.0 1.5 0.0 0.0 1.0 0.7 0.0 1.7 0.8 1.2 1.0 390.7 4.4 2.1 1.5 0.5 0.0 0.0 0.1 1.8 2.5 3.9 1.7 0.5 62.4 0.8 0.9 0.0 0.0 2.0 943.6 0.1 0.4 0.0 1.3 0.0 4.7 0.0 0.1 0.0 0.0 1.4 0.8 26.4 0.0 0.3 3.6 0.3 1.0 0.0 0.0 6.7 0.9 0.0 1.0 0.7 27.7 0.1 0.0 0.0 0.4 10.6 0.1 2.3 0.8 0.0 0.2 1.4 0.2 0.1 2.0 0.3 0.4 0.5 6.0 5.1 3.0 CYP27A1 "CP27, CTX, CYP27" ENSG00000135929 "Cytochrome P450 family 27 subfamily A member 1" Q02318 2 218781749-218815293 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol metabolism" "Monooxygenase, Oxidoreductase" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 7 "liver: 594.4" "Cell type enhanced" "Detected in many" "Hepatocytes: 404.3;Hofbauer cells: 148.9;Proximal enterocytes: 206.3" "Group enriched" "Detected in all" 4 "liver cancer: 176.9;melanoma: 85.7" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 8 "classical monocyte: 151.5;neutrophil: 126.3" "Group enriched" "Detected in many" 21 "granulocytes: 126.3;monocytes: 151.5" "Cell line enhanced" "Detected in many" "Hep G2: 299.6;HSkMC: 54.7;RPTEC TERT1: 78.5;SK-MEL-30: 103.6;WM-115: 42.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA059155 Enhanced Approved Mitochondria,Cytosol NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" Mitochondria Cytosol "HPA059155: AB_2683933" "prognostic favorable (1.05e-4)" "unprognostic (4.21e-2)" "unprognostic (2.34e-1)" "unprognostic (1.83e-3)" "unprognostic (3.71e-3)" "unprognostic (1.31e-2)" "prognostic favorable (8.62e-6)" "unprognostic (6.04e-2)" "unprognostic (1.73e-1)" "unprognostic (4.04e-1)" "unprognostic (1.25e-3)" "unprognostic (8.76e-3)" "unprognostic (1.09e-3)" "unprognostic (1.08e-1)" "unprognostic (7.51e-2)" "unprognostic (1.64e-1)" "unprognostic (1.36e-1)" 23.1 50.3 45.2 15.7 59.0 1.3 21.8 57.0 59.3 27.6 75.6 27.6 77.8 19.8 11.6 11.9 34.0 19.1 30.7 42.2 49.3 46.4 594.4 71.7 24.6 63.0 56.1 32.6 8.3 18.5 29.6 6.2 62.7 41.8 20.7 22.5 40.4 29.5 37.9 17.5 81.9 13.2 50.6 13.0 13.8 12.6 58.8 23.6 12.6 49.2 28.0 24.3 23.2 69.2 0.2 0.0 2.7 0.2 4.6 3.3 0.4 1.9 11.7 3.9 7.8 13.7 0.8 0.0 4.3 7.6 0.2 0.1 0.0 0.0 1.7 1.4 1.0 0.0 0.4 299.6 16.2 0.4 0.3 54.7 0.5 0.1 0.0 12.8 5.9 0.0 0.3 0.1 8.3 0.0 0.0 0.2 2.3 0.3 0.5 0.1 2.4 0.5 78.5 0.2 0.2 0.2 0.1 0.0 103.6 2.4 1.6 2.2 5.9 0.0 0.2 0.1 6.0 0.0 0.0 0.1 0.1 0.3 42.9 0.0 151.5 0.4 0.2 17.1 0.3 0.7 0.2 0.5 6.5 0.0 0.1 0.0 126.3 0.0 1.2 0.8 0.0 44.1 45.2 59.0 57.0 59.3 42.2 49.3 63.0 56.1 62.7 50.6 58.8 69.2 10.6 3.2 28.9 33.6 0.9 5.2 52.4 8.5 21.6 15.3 12.7 18.8 5.1 17.2 11.3 3.7 27.1 0.7 0.5 37.0 9.8 12.1 1.0 12.6 4.3 10.3 24.5 8.4 2.2 12.0 0.7 35.4 2.6 14.8 2.5 1.9 19.6 404.3 148.9 10.1 3.9 20.0 4.1 18.2 5.1 1.0 47.5 104.3 49.8 15.0 92.4 28.7 0.0 26.7 108.5 9.7 44.0 26.7 0.0 43.3 206.3 76.9 21.4 14.1 0.0 12.8 7.2 0.7 0.1 3.2 3.1 1.2 2.3 1.2 30.3 20.4 CYP4F8 ENSG00000186526 "Cytochrome P450 family 4 subfamily F member 8" P98187 19 15615218-15630639 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Fatty acid metabolism, Lipid metabolism" "Monooxygenase, Oxidoreductase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 15 "seminal vesicle: 215.6" "Cell type enhanced" "Detected in some" "Basal prostatic cells: 1.2;Breast glandular cells: 1.7;granulocytes: 1.3;NK-cells: 1.0;Prostatic glandular cells: 1.3;Skeletal myocytes: 1.7;Urothelial cells: 2.5" "Cancer enhanced" "Detected in some" "urothelial cancer: 10.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "SK-BR-3: 1.1" "Low region specificity" "Detected in all" HPA058960 Approved NA NA "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 50: Fibroblasts - ECM organization" "HPA058960: AB_2683862" "unprognostic (1.70e-2)" "unprognostic (5.46e-3)" "unprognostic (3.21e-2)" "unprognostic (3.97e-6)" "unprognostic (3.51e-3)" "unprognostic (2.72e-1)" "unprognostic (1.15e-1)" "unprognostic (8.25e-2)" "unprognostic (1.15e-2)" "unprognostic (1.02e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 5.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.8 0.0 0.0 0.2 215.6 0.0 12.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.2 0.0 0.0 0.4 1.7 0.3 0.7 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.5 0.2 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.3 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.9 0.0 0.3 0.0 0.0 0.1 0.1 1.0 0.0 0.0 0.1 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.7 0.0 1.7 0.2 0.0 0.2 0.0 0.0 0.1 0.2 0.0 0.3 2.5 CYP51A1 "CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1" ENSG00000001630 "Cytochrome P450 family 51 subfamily A member 1" Q16850 7 92112153-92134803 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" "Monooxygenase, Oxidoreductase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 204.7" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 67.3;Alveolar cells type 2: 169.7;Early spermatids: 74.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "GAMG: 481.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041325, HPA043508" Enhanced Enhanced "Endoplasmic reticulum" NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 37: Intestine - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 11: Alveolar cells - Smell perception" "Endoplasmic reticulum" "HPA041325: AB_2677411, HPA043508: AB_2678520" "unprognostic (6.68e-2)" "prognostic unfavorable (6.12e-4)" "unprognostic (3.48e-2)" "unprognostic (1.18e-2)" "unprognostic (7.82e-2)" "unprognostic (3.60e-2)" "unprognostic (1.02e-1)" "unprognostic (1.97e-1)" "unprognostic (9.84e-2)" "unprognostic (1.36e-1)" "unprognostic (9.75e-2)" "unprognostic (1.34e-1)" "unprognostic (1.59e-9)" "unprognostic (1.82e-1)" "unprognostic (2.73e-1)" "unprognostic (5.13e-2)" "unprognostic (1.09e-3)" 19.4 58.2 22.3 20.6 24.9 30.3 30.6 39.8 32.3 26.4 21.0 52.7 86.6 21.2 35.8 43.7 16.7 24.3 20.7 24.2 39.0 38.7 204.7 53.2 13.1 60.1 42.3 29.0 48.7 59.6 17.1 21.9 50.6 43.8 41.5 31.4 20.3 17.5 7.9 26.5 40.0 20.4 46.6 13.4 45.1 86.4 31.8 6.6 33.6 11.7 16.6 21.3 26.2 57.0 113.7 54.3 134.0 86.4 92.0 149.6 18.7 37.7 112.7 47.1 128.8 131.8 201.7 98.1 57.9 65.3 481.6 96.2 118.1 237.0 55.3 40.3 82.6 27.9 51.1 99.7 125.7 56.0 39.4 109.1 105.7 185.6 194.0 42.2 49.4 19.8 108.2 217.8 56.4 115.6 12.5 53.8 100.7 45.9 53.4 40.3 27.8 222.8 216.7 187.9 94.1 62.5 80.0 156.3 117.2 60.6 56.9 69.5 59.5 65.0 70.6 95.2 49.8 72.8 70.5 88.1 49.8 75.5 85.2 2.8 11.1 3.9 11.6 16.3 7.7 15.6 8.0 8.9 16.3 12.3 7.1 9.6 1.5 7.8 10.3 14.3 6.7 8.2 22.3 24.9 39.8 32.3 24.2 39.0 60.1 42.3 50.6 46.6 31.8 57.0 3.1 67.3 169.7 35.9 24.0 2.5 1.6 4.6 48.9 2.6 6.7 3.7 1.6 7.2 44.5 1.8 2.1 1.5 8.9 20.3 1.9 10.7 74.4 10.7 8.1 7.7 10.8 11.6 34.3 19.8 1.0 9.1 43.3 16.4 28.5 4.1 5.3 45.2 1.5 0.0 39.6 13.1 2.0 5.6 1.9 34.4 3.7 9.2 0.0 15.9 1.3 2.4 0.0 39.2 53.1 14.2 11.7 1.5 34.3 1.4 9.6 1.5 15.7 1.9 0.0 4.0 6.5 7.8 4.2 51.4 5.4 4.4 12.2 9.3 11.9 2.5 CYP7A1 CYP7 ENSG00000167910 "Cytochrome P450 family 7 subfamily A member 1" P22680 8 58490178-58500163 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Monooxygenase, Oxidoreductase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 80 "liver: 49.5" "Cell type enriched" "Detected in single" 17 "Hepatocytes: 7.0" "Cancer enriched" "Detected in single" 96 "liver cancer: 28.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 2: Hepatocytes - Metabolism" "unprognostic (5.20e-2)" "unprognostic (1.93e-2)" "unprognostic (1.77e-2)" "prognostic favorable (3.19e-4)" "unprognostic (7.60e-2)" "unprognostic (5.31e-2)" "unprognostic (1.50e-1)" "unprognostic (1.18e-1)" "unprognostic (2.64e-1)" "unprognostic (8.43e-3)" "unprognostic (3.01e-1)" "unprognostic (1.57e-2)" "unprognostic (1.51e-1)" 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.6 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 49.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 DHCR24 "DCE, KIAA0018, seladin-1" ENSG00000116133 "24-dehydrocholesterol reductase" Q15392 1 54849627-54887195 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Oxidoreductase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 1129.5;liver: 623.5" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 298.1;Alveolar cells type 2: 682.3;Hepatocytes: 1091.4;Theca cells: 442.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC diff: 1031.9" "Low region specificity" "Detected in all" "HPA017981, CAB037247, HPA063005" Enhanced NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 18: Non-specific - Mitochondria" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 15: Hepatocytes - Hemostasis" "CAB037247: AB_796187, HPA017981: AB_2732422, HPA063005: AB_2684919" "unprognostic (2.88e-1)" "unprognostic (1.80e-2)" "unprognostic (4.99e-3)" "prognostic unfavorable (1.05e-5)" "unprognostic (1.69e-1)" "unprognostic (2.61e-1)" "unprognostic (1.54e-2)" "unprognostic (1.85e-1)" "unprognostic (1.68e-1)" "unprognostic (1.86e-1)" "unprognostic (6.18e-3)" "unprognostic (3.35e-1)" "unprognostic (7.82e-3)" "unprognostic (5.48e-2)" "unprognostic (1.83e-1)" "unprognostic (1.70e-1)" "unprognostic (3.97e-2)" 58.3 1129.5 35.7 19.8 58.5 1.6 104.8 125.3 73.0 54.9 30.4 55.6 62.2 13.1 1.6 296.1 60.4 42.2 18.0 55.9 63.9 48.6 623.5 215.9 9.4 216.2 91.3 28.5 30.5 157.9 17.0 21.6 158.9 128.6 40.5 15.8 136.2 8.3 197.7 247.6 29.6 12.6 129.3 134.1 98.9 74.2 87.9 10.1 15.4 11.1 33.9 13.5 103.9 280.7 342.1 58.5 210.6 257.1 1031.9 219.0 50.5 94.8 160.3 130.7 268.6 341.6 210.2 55.3 191.5 82.4 427.4 319.2 250.5 501.3 118.3 8.3 159.6 303.3 131.8 421.7 168.9 126.7 68.2 161.0 429.0 397.6 74.7 66.7 67.2 124.5 224.7 0.2 50.2 143.5 25.8 111.4 592.0 90.7 164.2 0.3 54.2 166.3 735.3 257.1 144.5 53.2 185.0 337.5 123.1 221.6 441.5 143.3 62.2 45.3 130.0 66.1 183.9 22.7 55.0 91.2 32.8 215.3 60.4 5.1 1.5 0.7 6.0 1.8 0.3 3.7 2.5 2.6 5.2 1.3 2.2 2.9 0.0 2.7 0.7 3.0 0.4 4.4 35.7 58.5 125.3 73.0 55.9 63.9 216.2 91.3 158.9 129.3 87.9 280.7 6.2 298.1 682.3 12.4 13.3 31.5 17.3 150.6 79.1 9.7 87.9 33.1 15.3 145.8 205.2 68.0 0.0 35.2 6.4 133.3 3.9 55.3 22.9 14.5 5.8 13.5 24.0 71.6 14.5 76.5 34.4 17.5 38.7 44.7 32.2 26.4 111.0 1091.4 28.0 5.0 8.7 39.2 69.2 68.9 8.2 77.2 14.0 9.4 14.2 1.9 6.8 3.6 2.1 5.5 62.6 48.6 27.7 7.9 1.8 52.4 22.6 14.4 136.3 6.4 0.0 1.5 23.2 5.4 14.7 145.4 80.4 30.6 10.6 442.4 35.2 45.2 DHCR7 SLOS ENSG00000172893 "7-dehydrocholesterol reductase" Q9UBM7 11 71428193-71452868 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Oxidoreductase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 161.1" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 77.9;Granulosa cells: 81.3;Hepatocytes: 156.1;Theca cells: 103.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044280 Approved Supported "Endoplasmic reticulum" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 15: Liver - Metabolism" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 15: Hepatocytes - Hemostasis" "Endoplasmic reticulum" "HPA044280: AB_10794893" "unprognostic (1.76e-1)" "unprognostic (1.50e-3)" "unprognostic (1.32e-2)" "unprognostic (7.16e-3)" "unprognostic (2.69e-1)" "unprognostic (2.18e-3)" "unprognostic (8.57e-3)" "unprognostic (3.02e-2)" "unprognostic (4.91e-2)" "unprognostic (1.13e-1)" "unprognostic (1.08e-2)" "unprognostic (5.45e-2)" "prognostic favorable (6.93e-7)" "unprognostic (1.73e-1)" "unprognostic (1.01e-1)" "unprognostic (8.15e-2)" "prognostic unfavorable (5.67e-4)" 23.7 97.2 28.1 13.0 35.4 46.7 36.3 42.4 37.0 16.2 15.6 21.1 48.1 10.6 59.2 42.2 12.5 8.9 28.8 28.8 35.8 16.3 161.1 21.8 6.0 55.3 38.8 54.4 16.6 24.4 18.4 8.3 55.8 21.6 14.4 8.7 27.8 7.1 13.6 68.2 19.3 9.9 34.4 9.6 19.1 31.0 38.0 4.7 11.9 13.2 9.4 7.9 22.7 58.9 126.4 112.3 106.7 118.9 49.0 75.8 33.7 50.9 134.1 43.1 114.5 419.8 401.5 87.1 79.0 48.6 376.2 235.9 128.8 276.7 44.5 33.5 98.7 33.4 89.3 183.1 127.8 63.7 15.6 89.2 122.1 159.3 108.4 34.6 63.8 112.7 159.6 180.7 43.2 341.1 52.4 72.6 154.1 124.9 67.4 46.9 150.6 377.3 162.3 187.3 144.7 53.9 48.4 157.6 113.9 51.4 153.2 34.5 60.4 11.5 62.4 3.7 61.5 59.3 78.7 95.8 33.8 110.9 48.9 5.6 2.1 1.9 10.5 1.4 12.6 6.5 8.9 9.8 2.8 5.4 11.0 13.0 1.1 5.8 1.5 7.1 6.0 6.9 28.1 35.4 42.4 37.0 28.8 35.8 55.3 38.8 55.8 34.4 38.0 58.9 7.1 3.2 19.1 7.2 7.1 0.8 10.1 77.9 3.4 8.4 21.8 14.9 13.1 15.7 39.2 22.0 12.5 15.5 11.9 9.9 7.9 36.9 0.1 3.9 1.5 11.8 9.5 5.2 3.2 49.9 27.6 12.8 11.7 9.3 0.0 81.3 7.9 156.1 11.9 0.0 4.5 12.3 54.9 3.8 3.3 1.7 8.4 5.6 5.4 1.0 5.8 21.2 4.1 5.0 14.7 26.7 11.5 4.9 10.0 16.5 8.9 3.8 7.6 8.7 13.1 3.9 9.0 0.5 7.0 11.9 1.1 54.2 13.8 103.6 15.0 9.5 EBP "CDPX2, CHO2, CPX, CPXD" ENSG00000147155 "EBP cholestenol delta-isomerase" Q15125 X 48521799-48528716 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Isomerase "Cataract, Disease variant, Dwarfism, Ichthyosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 328.5" "Cell type enhanced" "Detected in all" "Hepatocytes: 674.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003130 Approved Supported "Endoplasmic reticulum" NA Yes "Cluster 44: Non-specific - Transcription" "Cluster 85: Liver - Metabolism" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 15: Hepatocytes - Hemostasis" "Endoplasmic reticulum" "HPA003130: AB_1078717" "unprognostic (1.90e-1)" "unprognostic (2.64e-2)" "unprognostic (2.80e-1)" "unprognostic (6.27e-2)" "unprognostic (3.41e-1)" "unprognostic (1.64e-1)" "unprognostic (1.13e-1)" "unprognostic (1.15e-1)" "unprognostic (1.34e-1)" "unprognostic (1.87e-1)" "unprognostic (4.72e-2)" "unprognostic (1.47e-1)" "unprognostic (5.14e-2)" "unprognostic (4.04e-2)" "unprognostic (5.39e-2)" "unprognostic (4.13e-1)" "unprognostic (1.36e-1)" 10.2 73.3 16.7 17.1 17.2 48.3 17.4 18.5 17.8 19.4 22.0 50.6 85.5 11.0 17.3 41.3 14.3 10.5 32.5 16.8 18.7 44.0 328.5 24.4 18.8 24.4 16.6 12.7 26.0 44.0 7.2 8.2 24.2 40.6 57.5 10.7 25.0 11.7 9.5 27.8 54.2 14.9 15.8 16.9 31.6 14.2 15.9 28.2 14.4 10.6 32.7 14.1 23.3 16.0 224.5 96.4 107.4 77.0 74.5 39.2 50.5 48.2 43.6 64.3 93.9 169.9 382.7 115.9 35.2 41.3 83.5 230.3 217.5 293.8 49.8 85.8 149.7 50.1 115.2 139.3 57.8 179.2 138.2 51.3 108.6 112.9 86.4 22.5 46.5 98.1 77.6 119.5 50.7 163.7 119.1 199.9 118.2 88.3 199.1 93.8 10.3 363.7 175.6 68.8 110.0 59.6 175.4 122.6 31.2 91.5 122.9 71.1 46.6 33.1 56.2 132.9 63.1 47.5 72.1 107.7 78.7 239.7 40.6 96.1 37.7 97.1 129.4 53.4 104.5 71.5 90.5 116.7 53.5 57.2 76.5 99.7 7.3 63.9 57.2 105.4 103.1 93.6 16.7 17.2 18.5 17.8 16.8 18.7 24.4 16.6 24.2 15.8 15.9 16.0 15.2 32.1 49.8 2.9 38.9 37.1 58.2 245.6 23.3 23.8 57.8 26.2 49.9 77.2 116.6 53.3 8.4 55.9 74.5 140.3 39.2 91.7 10.5 30.5 14.7 26.1 30.0 48.8 7.4 239.1 113.0 21.4 36.2 56.5 40.6 41.2 27.1 674.6 65.0 8.4 10.3 96.8 93.6 30.2 36.0 11.8 13.4 31.9 37.4 4.7 34.8 19.3 101.0 5.0 5.1 156.7 137.3 14.7 54.4 46.4 171.9 99.7 34.8 23.3 13.1 12.5 23.6 8.7 22.7 47.6 45.5 37.5 57.1 128.7 149.1 71.1 FDFT1 SQS ENSG00000079459 "Farnesyl-diphosphate farnesyltransferase 1" P37268 8 11795573-11839304 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" "Multifunctional enzyme, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Basal respiratory cells: 479.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Daudi: 133.1;RPMI-8226: 361.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008874 Approved Supported "Endoplasmic reticulum" NA NA "Cluster 37: B-cells - Transcription" "Cluster 72: Non-specific - Transcription" "Cluster 25: RPMI-8226 - Immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Endoplasmic reticulum" "HPA008874: AB_1078844" "unprognostic (2.33e-1)" "unprognostic (2.60e-1)" "prognostic favorable (4.92e-5)" "unprognostic (1.29e-2)" "unprognostic (1.46e-2)" "unprognostic (1.71e-1)" "unprognostic (8.10e-2)" "unprognostic (1.01e-1)" "unprognostic (2.39e-1)" "unprognostic (2.45e-1)" "unprognostic (2.31e-3)" "unprognostic (2.57e-1)" "prognostic favorable (6.59e-9)" "unprognostic (2.28e-1)" "unprognostic (4.06e-2)" "unprognostic (3.86e-1)" "unprognostic (2.06e-1)" 69.1 126.7 8.2 6.7 14.9 15.0 69.5 13.1 11.6 93.3 7.4 113.4 6.7 80.2 2.9 165.7 59.4 3.2 62.9 10.0 11.7 71.3 118.3 88.0 6.0 29.9 14.1 66.9 58.6 2.0 51.2 4.2 23.1 64.5 5.8 5.4 141.7 3.1 160.3 129.0 92.2 4.9 15.4 50.4 113.2 118.7 15.3 3.2 45.9 6.9 4.5 70.4 107.8 31.9 19.1 8.1 28.8 19.4 3.8 5.7 10.9 19.2 10.6 7.4 8.6 8.1 14.1 133.1 3.9 3.2 34.6 17.8 10.6 24.7 8.2 13.1 17.2 9.6 11.1 21.7 7.4 5.5 13.0 11.2 6.0 13.2 4.7 5.3 2.1 24.5 12.1 60.0 4.6 11.1 16.7 12.9 27.1 9.0 5.3 14.9 11.3 361.0 11.9 61.5 9.6 11.2 4.3 11.2 35.9 12.3 11.6 6.8 11.3 5.1 21.6 3.1 5.8 17.0 30.2 26.3 7.5 18.7 19.7 52.1 19.5 25.5 23.1 23.6 20.7 60.5 25.3 24.5 29.1 45.6 25.7 23.3 22.3 26.7 15.1 27.9 45.7 43.9 8.2 14.9 13.1 11.6 10.0 11.7 29.9 14.1 23.1 15.4 15.3 31.9 31.1 54.5 164.1 67.6 78.0 52.5 94.0 479.6 87.6 17.7 79.6 49.8 78.5 101.5 325.8 79.1 14.6 266.2 49.4 134.8 88.0 165.6 294.4 55.0 20.9 45.2 79.1 113.2 29.3 284.4 153.3 37.1 64.2 68.1 57.0 86.2 22.1 221.8 94.1 11.8 25.6 117.4 284.8 41.9 32.2 228.8 77.0 54.3 101.4 38.4 97.1 61.9 55.6 30.2 95.6 163.6 108.4 53.4 50.0 101.3 87.0 74.9 142.6 21.0 52.6 13.8 74.4 215.5 76.1 112.5 88.8 175.0 55.7 131.4 100.4 167.2 FDPS ENSG00000160752 "Farnesyl diphosphate synthase" P14324 1 155308748-155320666 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Host-virus interaction, Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Transferase "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 355.7" "Cell type enhanced" "Detected in all" "Basal respiratory cells: 927.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HBEC3-KT: 1187.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA028200 Approved Approved Nucleoplasm,Cytosol NA NA 1500000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 37: Intestine - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Cytosol Nucleoplasm "HPA028200: AB_10612109" "unprognostic (1.23e-1)" "unprognostic (8.46e-3)" "unprognostic (2.47e-2)" "unprognostic (6.57e-2)" "unprognostic (4.58e-2)" "unprognostic (2.84e-2)" "prognostic unfavorable (7.35e-4)" "unprognostic (4.21e-2)" "unprognostic (6.78e-3)" "unprognostic (1.64e-3)" "unprognostic (7.19e-2)" "unprognostic (2.25e-2)" "unprognostic (1.11e-2)" "unprognostic (8.25e-2)" "unprognostic (2.07e-1)" "unprognostic (5.65e-2)" "unprognostic (8.44e-2)" 73.5 188.2 48.2 66.5 50.4 69.5 68.8 60.1 58.8 63.4 51.1 88.7 167.2 57.5 73.0 142.5 57.4 39.8 72.2 49.9 64.6 78.0 355.7 86.1 76.1 71.1 62.5 45.0 75.7 67.9 40.4 72.5 77.5 56.1 102.9 45.9 82.6 42.7 60.9 107.1 81.1 66.0 53.6 59.3 81.5 42.0 55.0 72.6 46.8 66.7 102.3 47.0 76.8 55.0 293.9 156.2 561.5 204.4 128.7 467.7 199.6 136.8 268.1 213.6 344.2 255.4 677.7 222.3 323.6 120.6 506.9 319.1 338.9 1187.5 198.9 122.4 242.5 129.4 260.1 311.5 210.8 212.1 142.0 335.5 184.6 339.6 168.8 96.4 377.6 322.3 235.1 579.9 225.3 315.1 273.6 205.0 338.9 216.4 225.5 231.6 243.2 620.0 567.7 193.0 217.4 185.6 140.7 253.0 243.0 317.3 182.6 567.6 277.1 118.4 144.3 74.3 254.9 244.3 202.3 401.1 115.3 221.7 191.1 90.6 85.5 124.1 89.2 92.9 79.7 102.8 77.8 91.1 95.6 95.1 69.9 87.1 38.9 115.2 70.0 76.2 113.7 134.7 48.2 50.4 60.1 58.8 49.9 64.6 71.1 62.5 77.5 53.6 55.0 55.0 154.2 73.7 181.6 38.5 68.4 36.8 83.3 927.7 42.1 69.4 84.6 56.9 1.8 97.2 431.5 53.3 62.6 207.8 74.9 343.0 137.0 180.9 216.6 56.7 38.2 161.9 71.4 133.4 30.8 329.9 198.7 59.8 52.0 77.8 62.8 116.6 168.1 361.9 112.0 55.5 28.1 135.7 299.1 54.8 44.4 67.9 60.9 52.8 96.0 15.0 144.7 81.1 87.6 22.6 39.7 256.7 324.3 70.3 91.3 206.1 194.1 145.0 129.6 90.8 72.3 47.0 177.5 42.0 14.2 49.7 59.8 143.5 68.3 230.6 165.4 148.2 GGPS1 GGPPS1 ENSG00000152904 "Geranylgeranyl diphosphate synthase 1" O95749 1 235327350-235344532 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Isoprene biosynthesis" Transferase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 212.7;Late spermatids: 290.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029472, HPA050727" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 21: Non-specific - Transcription" "Cluster 43: THP-1 - Innate immune response" "Cluster 25: Spermatids - Spermatogenesis" Cytosol Nucleoplasm "HPA029472: AB_10696206, HPA050727: " "unprognostic (7.45e-2)" "unprognostic (3.18e-2)" "unprognostic (1.25e-1)" "unprognostic (2.23e-2)" "unprognostic (1.43e-1)" "unprognostic (3.10e-3)" "prognostic unfavorable (6.69e-4)" "unprognostic (4.50e-2)" "unprognostic (3.66e-2)" "unprognostic (3.77e-3)" "unprognostic (2.66e-2)" "unprognostic (8.77e-3)" "unprognostic (1.95e-2)" "unprognostic (1.99e-1)" "unprognostic (3.35e-2)" "unprognostic (1.41e-1)" "unprognostic (1.70e-2)" 24.0 23.5 20.4 17.3 21.4 7.8 34.1 23.0 27.6 24.5 18.5 24.8 21.2 23.3 30.4 22.4 21.2 20.0 23.5 21.1 22.5 27.8 21.7 20.1 21.3 21.8 20.6 23.3 16.4 21.1 17.6 19.2 22.3 29.4 23.9 38.8 31.2 19.7 29.8 20.3 20.6 25.7 22.3 20.5 20.4 48.2 20.9 27.6 27.4 28.9 21.9 23.6 17.0 25.7 41.3 22.3 54.5 41.5 41.7 59.9 20.5 36.2 50.7 23.6 33.1 17.5 64.5 28.1 51.3 40.6 38.1 33.5 29.4 37.8 31.2 28.8 54.4 24.0 19.7 29.9 46.9 30.0 19.7 39.3 66.5 32.2 43.0 41.8 42.5 46.2 58.5 24.7 31.5 24.6 37.0 35.7 46.4 109.9 11.5 22.6 17.3 32.6 66.2 22.4 43.3 59.8 27.3 61.5 54.7 20.1 76.7 46.5 35.9 27.9 20.8 47.6 34.7 42.0 55.8 34.3 35.4 33.3 51.4 43.7 31.0 48.5 31.5 37.3 32.1 38.6 39.5 33.8 30.4 32.8 36.2 33.4 27.8 31.9 54.2 25.2 42.5 36.8 20.4 21.4 23.0 27.6 21.1 22.5 21.8 20.6 22.3 22.3 20.9 25.7 18.3 32.1 34.5 16.3 27.2 39.9 60.4 64.6 27.9 32.1 29.1 22.4 24.5 17.2 39.5 20.2 43.8 30.7 24.1 21.4 72.4 37.5 212.7 16.8 15.1 29.4 17.4 12.0 26.5 28.3 43.7 31.0 14.3 12.9 24.6 16.4 28.9 13.0 26.8 48.8 25.7 26.1 69.2 26.9 49.0 290.7 35.8 24.3 67.6 20.6 36.7 55.4 36.0 15.6 23.2 31.8 23.3 35.0 8.5 65.6 29.3 61.3 30.4 51.2 26.3 26.1 32.5 111.6 50.0 18.7 40.6 47.1 33.0 30.9 22.7 55.9 HMGCL HL ENSG00000117305 "3-hydroxy-3-methylglutaryl-CoA lyase" P35914 1 23801885-23838620 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Lyase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 322.5" "Cell type enhanced" "Detected in all" "Hepatocytes: 172.4;Proximal tubular cells: 216.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004727 Enhanced "Intracellular and membrane" NA NA 34000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 85: Liver - Metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA004727: AB_1079074" "unprognostic (8.24e-2)" "unprognostic (3.21e-2)" "prognostic favorable (7.67e-4)" "unprognostic (1.23e-3)" "unprognostic (5.47e-3)" "unprognostic (1.26e-1)" "unprognostic (2.04e-1)" "unprognostic (3.85e-2)" "unprognostic (1.08e-1)" "unprognostic (2.24e-1)" "unprognostic (3.05e-1)" "unprognostic (8.24e-2)" "prognostic favorable (5.07e-8)" "unprognostic (1.72e-1)" "unprognostic (2.46e-2)" "unprognostic (8.60e-2)" "unprognostic (3.39e-3)" 27.5 63.0 26.3 16.8 27.5 7.5 25.8 27.5 28.3 27.5 33.0 53.3 45.7 20.2 47.2 32.8 35.6 26.3 42.5 24.6 26.9 115.5 322.5 23.6 21.7 28.0 26.2 21.6 33.4 60.2 26.3 19.9 27.7 31.7 52.9 16.1 30.3 27.9 63.7 25.5 40.0 23.3 27.4 26.8 40.9 17.9 30.1 23.4 40.5 70.2 25.1 28.6 24.2 29.6 28.5 16.0 17.7 13.4 70.6 53.5 6.8 22.0 38.3 23.3 28.2 10.2 53.7 14.8 44.3 34.6 19.0 22.4 21.3 35.7 25.2 30.4 16.1 19.8 13.8 23.5 90.9 7.8 12.7 62.4 52.0 30.8 58.5 62.5 32.2 27.4 20.6 20.3 43.3 29.3 12.2 15.3 4.6 77.4 22.1 17.2 14.5 27.9 55.4 14.5 14.8 13.2 28.6 10.8 49.3 23.3 33.9 19.3 24.3 19.3 11.6 35.5 9.7 28.7 15.2 13.3 47.7 28.7 23.0 103.5 67.0 66.0 36.3 66.0 39.8 45.9 39.1 42.1 58.0 51.2 39.6 37.7 25.5 54.4 77.5 43.9 45.5 61.7 26.3 27.5 27.5 28.3 24.6 26.9 28.0 26.2 27.7 27.4 30.1 29.6 19.9 12.8 25.7 14.0 16.3 5.9 29.9 54.3 9.6 24.6 19.9 17.1 33.7 41.5 30.6 49.7 18.8 43.0 10.0 48.1 119.3 57.7 2.3 25.0 17.5 22.5 9.0 18.7 4.3 24.0 27.3 20.8 30.5 23.1 17.7 29.7 30.4 172.4 61.6 35.3 5.3 49.5 28.5 23.5 7.7 3.6 21.8 23.5 21.4 8.4 41.4 37.1 24.7 6.0 12.5 31.2 53.8 24.5 8.3 29.4 70.9 216.8 31.5 25.5 6.6 17.1 21.6 6.6 5.4 13.8 6.5 41.3 15.2 65.6 48.9 24.3 HMGCLL1 "bA418P12.1, DKFZP434G1411" ENSG00000146151 "3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1" Q8TB92 6 55434373-55579197 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 10.6" "Cell type enhanced" "Detected in some" "Astrocytes: 49.9;Excitatory neurons: 80.7;Inhibitory neurons: 76.2;Oligodendrocytes: 23.5" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "SCLC-21H: 5.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "unprognostic (2.74e-3)" "unprognostic (1.54e-2)" "unprognostic (4.08e-3)" "unprognostic (6.11e-2)" "unprognostic (1.41e-1)" "unprognostic (9.54e-3)" "unprognostic (8.97e-3)" "unprognostic (2.12e-2)" "unprognostic (9.27e-3)" "unprognostic (4.11e-2)" "unprognostic (1.18e-4)" "unprognostic (3.13e-3)" "unprognostic (7.57e-2)" "unprognostic (2.55e-1)" "unprognostic (1.52e-1)" 1.4 3.6 6.1 0.2 5.9 0.0 1.4 5.9 5.2 0.8 0.0 0.8 0.2 0.2 0.0 1.0 0.4 0.6 1.8 5.5 10.6 0.9 0.7 2.6 0.3 5.6 6.3 0.4 1.6 0.1 4.7 6.2 6.6 3.0 0.8 4.5 0.8 1.0 1.1 0.1 0.9 0.5 9.2 0.0 1.0 2.6 8.3 0.6 0.4 2.8 0.2 0.9 0.7 9.4 0.0 0.4 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.9 0.2 0.0 0.0 0.0 1.1 0.5 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.1 5.9 5.9 5.2 5.5 10.6 5.6 6.3 6.6 9.2 8.3 9.4 0.6 0.0 1.3 49.9 0.0 0.0 0.0 0.0 1.2 15.1 3.7 2.4 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.1 0.5 0.0 0.0 80.7 0.0 0.0 5.8 0.0 0.0 0.0 3.5 3.9 0.0 0.1 0.0 76.2 0.0 0.0 0.3 0.0 1.3 0.3 0.1 0.0 15.0 0.0 1.5 0.0 5.5 23.5 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.3 0.0 0.9 5.6 1.3 1.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 HMGCR ENSG00000113161 "3-hydroxy-3-methylglutaryl-CoA reductase" P04035 5 75336329-75364001 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Oxidoreductase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 105.7" "Cell type enhanced" "Detected in all" "Glandular and luminal cells: 239.5;Theca cells: 148.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008338, CAB016797, CAB078688" Supported NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 37: Intestine - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 44: Endometrium - Transcription" "CAB016797: , CAB078688: AB_2665607, HPA008338: AB_10960401" "unprognostic (5.07e-2)" "unprognostic (1.65e-2)" "unprognostic (3.65e-3)" "unprognostic (1.02e-2)" "unprognostic (1.65e-3)" "unprognostic (1.02e-1)" "unprognostic (1.45e-1)" "unprognostic (4.41e-2)" "unprognostic (5.45e-2)" "unprognostic (1.90e-2)" "unprognostic (1.41e-1)" "unprognostic (3.99e-2)" "prognostic favorable (9.42e-6)" "unprognostic (2.44e-1)" "unprognostic (2.55e-2)" "unprognostic (3.64e-3)" "unprognostic (4.37e-2)" 10.8 39.5 19.8 18.1 20.7 24.6 30.8 15.7 23.0 20.1 16.2 45.2 38.1 16.8 25.3 49.1 12.2 15.2 7.4 21.5 25.0 21.1 105.7 24.2 14.7 26.6 21.3 9.7 16.5 24.8 8.2 17.7 25.2 23.3 37.3 18.7 15.5 8.1 6.4 55.2 26.5 12.9 14.2 14.8 27.6 23.3 20.5 17.8 23.4 7.1 18.6 14.1 26.7 17.5 68.5 25.6 260.7 89.2 54.9 103.4 65.5 19.3 53.6 38.6 85.0 95.8 163.7 60.3 68.7 31.7 245.2 84.5 136.4 225.9 39.4 20.8 50.8 47.0 36.7 78.6 80.8 39.8 32.9 66.8 130.7 133.6 65.6 19.2 31.5 84.8 50.4 86.4 61.0 45.2 72.7 39.9 112.5 17.7 19.7 50.7 78.7 86.5 155.2 154.5 91.0 41.3 41.4 43.7 38.3 89.6 43.1 102.4 37.2 20.5 30.0 22.4 32.8 28.1 38.1 83.2 29.7 75.2 43.7 10.0 14.8 8.8 7.7 8.9 6.2 5.1 5.2 7.8 16.9 5.2 5.3 7.2 28.8 12.5 10.5 4.9 9.0 7.5 19.8 20.7 15.7 23.0 21.5 25.0 26.6 21.3 25.2 14.2 20.5 17.5 11.6 19.2 43.3 23.2 14.9 41.4 10.1 37.6 43.3 23.5 19.0 12.1 7.0 12.8 33.3 27.6 18.8 19.7 25.7 80.4 3.9 13.5 46.6 124.4 34.3 13.4 43.0 11.6 49.9 22.0 24.0 13.7 28.5 239.5 24.1 71.3 7.9 97.5 13.1 40.4 35.8 56.0 28.5 14.8 11.8 22.2 9.3 19.5 16.0 15.0 12.1 9.7 7.2 28.1 24.7 15.0 40.0 6.0 14.4 18.4 15.5 6.9 31.6 15.2 13.1 7.0 20.2 23.4 12.0 69.8 91.6 46.7 19.2 148.7 30.4 18.8 HMGCS1 HMGCS ENSG00000112972 "3-hydroxy-3-methylglutaryl-CoA synthase 1" Q01581 5 43287470-43313512 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 390.2" "Cell type enhanced" "Detected in many" "Hepatocytes: 511.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "AF22: 797.7;GAMG: 523.5;HBEC3-KT: 467.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032907, HPA036913, HPA036914" Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" No No 470000 "Cluster 44: Non-specific - Transcription" "Cluster 85: Liver - Metabolism" "Cluster 12: NES - Nervous system development" "Cluster 15: Hepatocytes - Hemostasis" "Nucleoplasm, Cytosol" "Plasma membrane" "CAB032907: AB_2118319, HPA036913: AB_2675380, HPA036914: AB_10671751" "unprognostic (1.31e-1)" "unprognostic (5.12e-3)" "unprognostic (6.82e-3)" "unprognostic (4.59e-2)" "unprognostic (8.39e-2)" "unprognostic (2.49e-2)" "unprognostic (1.03e-1)" "unprognostic (3.14e-2)" "unprognostic (1.27e-2)" "unprognostic (3.13e-1)" "unprognostic (6.40e-3)" "unprognostic (9.15e-2)" "prognostic favorable (3.87e-6)" "unprognostic (1.09e-1)" "unprognostic (9.22e-2)" "unprognostic (3.03e-2)" "unprognostic (2.37e-2)" 19.2 55.2 25.2 27.2 32.9 15.8 40.1 23.0 38.6 56.4 16.8 50.2 93.6 19.8 36.1 137.5 12.4 23.3 16.1 36.1 44.6 32.8 390.2 51.4 21.5 46.5 34.7 21.6 26.6 31.7 15.0 22.5 47.2 40.5 45.4 34.2 53.2 15.7 17.8 85.9 47.2 19.9 24.7 14.8 43.4 33.2 35.3 19.1 23.6 16.7 31.5 18.3 69.5 30.4 103.4 48.8 797.7 93.0 45.8 178.4 54.1 16.2 63.8 22.8 45.2 86.6 146.6 108.4 35.6 23.3 523.5 80.2 199.7 467.2 24.1 23.5 240.7 40.1 45.3 119.3 71.3 88.0 28.0 98.5 56.2 119.5 47.9 14.0 23.7 98.4 73.1 291.7 19.4 48.9 81.3 111.9 143.1 41.7 25.9 57.5 111.9 121.8 357.7 158.2 68.2 33.0 83.6 41.4 25.9 114.5 63.6 116.7 28.3 17.1 85.7 18.0 15.5 38.8 64.0 148.3 15.0 106.2 15.5 3.3 1.8 1.9 2.4 3.3 2.4 3.8 2.6 3.4 3.5 2.9 2.2 3.1 3.0 3.2 3.6 2.9 2.6 1.6 25.2 32.9 23.0 38.6 36.1 44.6 46.5 34.7 47.2 24.7 35.3 30.4 27.8 67.3 172.6 70.5 44.8 108.3 42.3 93.8 68.3 43.6 46.3 30.0 8.9 47.1 79.2 47.8 52.1 22.3 43.3 211.2 13.7 43.0 9.0 47.1 20.2 31.3 92.1 22.3 44.9 59.8 41.1 32.3 100.4 98.6 58.5 56.6 22.1 511.7 25.5 48.8 42.6 101.9 75.3 21.9 38.2 3.2 12.8 27.5 26.6 15.0 49.1 26.4 14.4 53.3 41.8 50.4 132.3 14.3 38.1 149.2 56.8 21.4 51.1 50.1 0.0 40.1 32.8 20.0 8.7 197.9 236.4 44.5 36.4 129.4 62.9 74.5 HSD17B4 "DBP, MFE-2, SDR8C1" ENSG00000133835 "Hydroxysteroid 17-beta dehydrogenase 4" P51659 5 119452473-119637199 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" "Isomerase, Lyase, Oxidoreductase" "Deafness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 320.0" "Cell type enhanced" "Detected in all" "Hepatocytes: 225.1;Oligodendrocytes: 221.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 75.5" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021302, HPA021311, HPA021479" Enhanced Enhanced Peroxisomes NA NA 450000 "Cluster 2: Granulocytes - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Peroxisomes "HPA021302: AB_1844350, HPA021311: AB_1844351, HPA021479: AB_1844352" "unprognostic (1.03e-1)" "unprognostic (1.05e-1)" "prognostic favorable (1.33e-4)" "unprognostic (3.21e-2)" "unprognostic (1.24e-2)" "unprognostic (3.12e-2)" "unprognostic (2.83e-3)" "unprognostic (5.47e-2)" "unprognostic (1.54e-1)" "unprognostic (2.03e-2)" "unprognostic (1.02e-1)" "unprognostic (3.85e-1)" "prognostic favorable (6.31e-6)" "unprognostic (1.60e-1)" "unprognostic (8.26e-2)" "unprognostic (1.80e-1)" "unprognostic (6.65e-3)" 74.4 85.0 37.2 41.9 50.2 19.7 44.4 51.1 50.0 68.8 47.2 64.5 79.3 34.1 53.0 50.9 39.1 52.5 68.6 34.9 50.7 84.4 320.0 75.6 33.2 50.6 49.5 34.8 55.2 75.5 26.5 53.4 49.2 56.8 65.9 27.2 44.9 79.0 59.8 51.8 87.6 39.5 44.7 36.6 53.8 20.9 49.9 31.9 133.9 52.8 39.7 57.7 31.5 56.3 68.8 59.8 104.1 143.7 261.8 120.3 57.9 63.4 80.3 57.3 103.0 49.4 112.8 84.4 128.0 70.6 81.0 68.7 77.0 144.4 84.3 94.6 79.8 118.1 62.0 96.9 65.8 38.0 169.9 110.0 56.3 64.9 54.7 69.3 103.9 59.4 41.0 48.9 64.2 64.0 59.2 23.6 82.1 161.1 43.1 68.7 103.0 104.8 92.2 192.7 81.1 70.6 149.0 23.4 78.7 93.3 88.7 68.2 67.6 52.7 38.1 66.5 53.1 26.3 55.3 32.6 63.7 104.4 56.7 75.5 27.3 49.9 6.5 15.5 7.3 11.1 5.8 5.3 21.3 10.3 5.5 5.2 4.9 6.9 17.1 13.8 4.1 12.2 37.2 50.2 51.1 50.0 34.9 50.7 50.6 49.5 49.2 44.7 49.9 56.3 38.9 73.7 125.2 47.3 28.2 14.9 42.5 43.2 24.5 19.7 31.1 22.1 76.4 64.3 52.3 36.8 14.6 64.3 19.1 40.0 84.1 39.9 8.8 29.0 48.9 32.3 33.0 42.1 92.9 35.8 29.3 35.6 48.4 35.8 68.4 25.3 32.2 225.1 77.9 15.2 102.8 45.8 22.4 51.8 13.8 13.4 34.5 46.7 8.8 49.6 85.7 47.3 9.2 78.4 221.5 20.5 29.6 51.1 23.1 24.8 85.7 65.4 33.8 18.6 6.6 29.2 32.2 30.6 22.7 34.7 17.2 65.0 15.7 57.2 55.3 39.7 HSD17B7 "PRAP, SDR37C1" ENSG00000132196 "Hydroxysteroid 17-beta dehydrogenase 7" P56937 1 162790702-162812817 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis" Oxidoreductase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 30.2" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA047496 Approved NA NA "Cluster 44: Non-specific - Transcription" "Cluster 85: Liver - Metabolism" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 15: Hepatocytes - Hemostasis" "HPA047496: AB_2680068" "unprognostic (2.93e-1)" "unprognostic (1.36e-2)" "unprognostic (6.03e-2)" "unprognostic (1.12e-1)" "unprognostic (2.34e-1)" "unprognostic (1.63e-3)" "unprognostic (2.57e-1)" "unprognostic (2.51e-2)" "unprognostic (1.36e-1)" "unprognostic (1.38e-1)" "unprognostic (1.94e-1)" "unprognostic (1.37e-1)" "prognostic unfavorable (8.47e-5)" "unprognostic (6.25e-2)" "unprognostic (1.90e-1)" "unprognostic (6.35e-2)" "unprognostic (3.17e-2)" 4.3 16.1 3.3 5.1 3.1 2.8 8.2 3.0 6.0 5.6 3.8 6.4 6.7 4.0 7.2 8.9 5.1 4.2 3.5 2.9 4.0 5.2 30.2 7.6 8.3 3.8 3.7 6.8 5.3 5.1 7.7 4.6 3.9 5.9 8.0 4.0 6.2 3.5 6.0 7.6 6.6 4.4 3.3 5.6 5.9 2.6 3.7 8.1 6.1 2.8 8.1 5.5 5.6 3.7 12.6 12.2 32.4 13.8 18.4 18.3 20.2 4.6 15.9 9.4 19.0 17.0 35.7 29.6 10.6 4.4 58.3 19.1 30.6 43.4 9.9 12.4 15.5 7.7 8.2 26.8 15.2 13.9 12.7 11.6 23.5 36.8 11.6 7.4 15.7 19.4 14.5 19.0 8.3 8.9 17.7 13.7 20.5 24.4 15.3 9.5 19.3 18.5 33.3 19.5 27.6 14.6 8.0 7.7 7.9 27.5 12.3 17.1 9.8 4.4 10.2 6.7 10.0 11.2 12.7 29.4 6.6 1.2 11.1 21.7 6.7 12.1 13.6 6.8 14.8 12.6 10.1 13.7 6.9 11.9 12.9 12.4 5.5 8.2 8.5 10.0 17.9 12.2 3.3 3.1 3.0 6.0 2.9 4.0 3.8 3.7 3.9 3.3 3.7 3.7 8.8 0.0 25.5 22.5 22.6 11.0 19.5 48.3 35.9 23.6 24.9 11.9 2.4 12.8 26.1 11.0 62.6 17.2 19.9 14.9 3.9 16.9 2.0 9.4 7.9 12.0 6.0 4.2 8.4 27.1 15.1 13.1 8.6 9.3 5.1 32.8 8.9 62.0 13.4 11.8 9.1 14.5 18.3 5.0 16.9 1.9 6.8 12.2 17.8 5.6 10.6 14.3 16.5 12.5 22.6 15.0 17.9 7.2 18.1 19.0 12.1 10.2 19.9 44.1 0.0 5.9 10.5 4.9 6.6 15.6 12.6 19.2 23.5 34.1 11.6 12.6 IDI1 ENSG00000067064 "Isopentenyl-diphosphate delta isomerase 1" Q13907 10 1039152-1049119 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Isomerase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039169 Approved NA NA 28000 "Cluster 2: Granulocytes - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 15: Hepatocytes - Hemostasis" "HPA039169: AB_10674280" "unprognostic (1.61e-2)" "unprognostic (2.59e-2)" "unprognostic (4.58e-2)" "unprognostic (1.97e-1)" "unprognostic (5.72e-3)" "unprognostic (1.27e-1)" "unprognostic (1.76e-2)" "unprognostic (1.97e-1)" "unprognostic (3.72e-2)" "unprognostic (3.88e-2)" "unprognostic (2.59e-1)" "unprognostic (2.26e-1)" "prognostic favorable (1.46e-4)" "unprognostic (9.63e-2)" "unprognostic (2.01e-2)" "unprognostic (2.19e-3)" "unprognostic (2.61e-2)" 32.2 93.7 36.9 36.6 38.9 133.9 152.1 44.6 44.2 24.5 36.9 37.3 66.7 17.0 28.5 50.5 16.7 21.9 24.6 39.9 46.8 41.3 160.2 39.9 39.0 49.4 46.9 26.7 31.3 25.9 43.9 23.4 51.1 50.2 34.3 37.5 26.3 13.4 105.9 37.9 34.8 17.7 42.4 44.0 37.2 25.3 44.0 26.3 21.8 44.7 39.8 20.0 30.8 47.0 89.5 33.4 173.4 42.0 71.1 154.1 25.2 36.7 41.5 42.4 88.7 89.6 136.8 80.9 23.6 40.8 101.7 75.8 97.8 177.8 38.3 27.9 93.8 78.2 50.1 103.2 83.9 30.4 37.5 99.3 73.2 119.3 15.6 18.1 33.4 75.0 54.5 111.1 72.2 72.4 59.1 51.9 69.0 74.6 19.5 67.2 82.0 89.5 185.7 79.7 26.6 31.6 46.4 96.5 100.7 53.5 99.3 103.8 33.4 22.7 12.9 66.8 27.2 64.3 64.7 151.3 28.2 89.4 20.4 76.0 15.1 37.6 27.6 28.3 27.5 25.8 21.0 22.7 13.9 26.0 15.3 22.6 41.4 24.2 33.5 14.4 24.8 26.6 36.9 38.9 44.6 44.2 39.9 46.8 49.4 46.9 51.1 42.4 44.0 47.0 119.2 73.7 144.3 53.8 176.2 89.6 80.4 175.7 58.1 77.4 110.0 70.0 79.0 51.5 109.6 40.5 37.5 63.3 233.5 167.5 150.6 62.9 277.8 61.5 28.6 64.6 106.0 31.1 36.2 102.6 53.6 62.8 79.5 108.2 100.7 60.5 67.1 322.8 86.9 63.9 41.0 107.6 156.6 59.1 63.2 101.5 26.4 88.8 133.4 20.6 55.8 130.9 118.4 47.3 65.1 81.9 130.9 29.7 60.2 116.6 70.5 63.5 65.6 70.3 26.3 62.3 73.4 82.5 37.0 79.2 144.6 187.2 154.9 171.1 65.0 121.2 IDI2 IPPI2 ENSG00000148377 "Isopentenyl-diphosphate delta isomerase 2" Q9BXS1 10 1018910-1025859 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Isomerase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 23 "skeletal muscle: 273.8" "Cell type enhanced" "Detected in some" "Alveolar cells type 2: 1.1;Glandular and luminal cells: 1.1;Horizontal cells: 1.7;Skeletal myocytes: 3.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA041254 Uncertain Vesicles NA NA "Cluster 33: Striated muscle - Muscle contraction" "Cluster 37: Myocytes - Muscle contraction" Vesicles "HPA041254: AB_10794270" "unprognostic (6.69e-3)" "unprognostic (4.05e-2)" "unprognostic (1.64e-1)" 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.7 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.0 2.8 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.2 0.0 0.1 0.0 0.2 0.1 0.0 1.2 0.0 0.0 273.8 0.3 0.0 0.0 0.0 0.0 0.1 0.1 0.6 0.1 0.0 11.8 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.7 0.4 0.3 0.0 0.1 0.2 0.2 0.0 0.6 0.3 0.5 0.0 1.1 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.4 0.4 0.0 0.0 0.6 0.0 0.0 0.0 0.4 0.2 0.0 0.0 0.9 0.5 0.4 0.2 0.0 0.0 0.3 0.0 0.1 0.1 0.0 1.1 0.0 0.1 0.0 0.0 0.2 1.7 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.4 0.0 0.5 0.3 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 3.2 0.2 0.3 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.2 LIPA "CESD, LAL" ENSG00000107798 "Lipase A, lysosomal acid type" P38571 10 89213569-89414557 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Lipid degradation, Lipid metabolism" Hydrolase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 398.4" "Cell type enhanced" "Detected in many" "Hofbauer cells: 515.0;Kupffer cells: 714.8;Macrophages: 303.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "classical monocyte: 167.3;intermediate monocyte: 355.1;myeloid DC: 123.6;non-classical monocyte: 198.5" "Group enriched" "Detected in all" 6 "dendritic cells: 123.6;monocytes: 355.1" "Cell line enhanced" "Detected in many" "A-431: 354.4;AN3-CA: 367.8;ASC TERT1: 450.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034892, HPA057052" Enhanced Supported "Nucleoplasm,Nucleoli fibrillar center,Vesicles,Cytosol" "Intracellular and membrane" NA NA 280000 "Cluster 7: Monocytes - Unknown function" "Cluster 64: Macrophages - Immune response" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 4: Macrophages - Innate immune response" "Vesicles, Cytosol" "Nucleoplasm, Nucleoli fibrillar center" "CAB034892: AB_784329, HPA057052: AB_2683322" "unprognostic (1.27e-1)" "unprognostic (3.23e-1)" "unprognostic (1.17e-1)" "unprognostic (1.07e-1)" "unprognostic (1.61e-1)" "unprognostic (2.55e-2)" "unprognostic (7.14e-2)" "unprognostic (1.66e-1)" "unprognostic (1.19e-1)" "unprognostic (4.28e-2)" "unprognostic (1.08e-1)" "unprognostic (7.30e-3)" "unprognostic (1.39e-2)" "unprognostic (1.40e-1)" "unprognostic (4.42e-2)" "unprognostic (3.42e-2)" "unprognostic (5.71e-2)" 76.0 46.3 43.5 66.7 65.2 39.8 47.8 64.1 74.4 54.0 39.0 67.7 167.6 38.8 21.7 28.6 37.8 83.5 24.2 43.5 53.1 44.9 218.9 169.5 159.3 74.7 55.5 32.7 21.4 68.9 12.7 79.1 82.2 30.7 72.0 12.6 22.5 33.8 11.8 18.7 227.5 47.7 65.4 398.4 34.3 13.4 57.0 44.5 31.6 22.5 45.5 58.4 19.3 115.5 354.4 49.4 30.7 367.8 343.5 450.8 10.0 171.4 194.8 65.5 121.5 18.6 176.6 63.9 34.0 264.4 73.7 338.7 13.8 92.8 53.6 86.1 34.7 25.1 19.1 81.5 87.6 48.8 48.9 190.4 69.2 72.9 40.6 88.2 14.9 45.4 0.3 108.5 58.3 28.2 45.7 34.6 22.7 62.4 60.0 26.4 39.0 60.5 69.2 50.9 10.5 21.8 41.4 49.9 133.9 20.4 64.4 65.8 26.2 58.8 15.5 132.1 44.6 60.0 65.7 25.8 71.4 112.9 82.1 4.2 167.3 16.9 40.0 355.1 40.6 31.9 35.8 38.8 123.6 33.4 36.7 40.4 7.1 29.8 198.5 25.0 38.2 159.6 43.5 65.2 64.1 74.4 43.5 53.1 74.7 55.5 82.2 65.4 57.0 115.5 75.5 41.7 33.8 11.1 35.9 17.7 30.3 58.1 25.6 5.4 16.1 14.1 9.6 45.8 31.9 33.1 0.0 34.8 31.4 2.8 21.5 35.1 6.8 11.4 20.4 56.7 21.8 27.4 34.4 36.2 32.9 34.6 21.4 15.5 28.5 10.8 54.7 66.7 515.0 16.8 15.1 8.9 40.7 714.8 69.0 2.7 11.5 303.1 48.0 30.0 71.7 33.1 29.9 15.1 143.0 19.3 12.0 21.8 15.4 11.3 161.0 14.0 28.8 2.2 6.6 19.7 21.0 5.1 13.8 31.9 12.5 20.0 33.1 17.6 9.1 24.0 LSS OSC ENSG00000160285 "Lanosterol synthase" P48449 21 46188141-46228824 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis" Isomerase "Cataract, Disease variant, Hypotrichosis, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hepatocytes: 132.0;Oligodendrocytes: 158.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "GAMG: 234.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA032060, HPA032062, CAB034116" Supported NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 15: Liver - Metabolism" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 15: Hepatocytes - Hemostasis" "CAB034116: AB_2138611, HPA032060: AB_10671085, HPA032062: AB_2674134" "unprognostic (2.78e-3)" "unprognostic (8.53e-3)" "unprognostic (6.95e-2)" "unprognostic (2.07e-1)" "unprognostic (1.74e-2)" "unprognostic (1.06e-1)" "unprognostic (2.74e-2)" "unprognostic (1.33e-2)" "unprognostic (1.72e-1)" "unprognostic (1.58e-2)" "unprognostic (1.68e-2)" "unprognostic (2.02e-2)" "unprognostic (2.34e-2)" "prognostic unfavorable (6.80e-4)" "unprognostic (1.92e-1)" "unprognostic (2.50e-1)" "prognostic unfavorable (3.07e-4)" 29.3 38.9 20.0 10.8 30.8 5.7 22.3 38.9 33.5 20.8 7.1 22.9 28.5 26.6 12.1 39.7 18.0 9.0 25.1 15.7 26.2 10.7 54.8 24.1 9.4 62.3 40.7 30.3 19.4 12.2 25.9 8.0 65.7 24.0 10.7 6.8 16.1 12.4 29.0 27.6 17.4 12.2 28.4 7.6 23.3 17.5 40.4 12.3 10.2 19.5 8.0 20.2 19.6 58.7 70.4 22.2 70.9 30.6 94.1 90.6 20.3 26.8 186.4 32.1 62.7 73.9 54.4 15.4 22.3 51.7 234.6 32.7 63.2 110.9 12.9 14.9 34.5 37.7 38.6 48.3 85.5 13.7 25.1 89.0 41.4 59.7 25.6 22.2 26.9 72.1 37.4 87.3 27.8 23.8 29.9 19.7 115.4 11.3 20.1 34.9 21.9 92.2 82.8 38.1 41.4 36.7 31.4 24.0 27.5 30.6 38.0 33.7 40.8 37.9 30.2 33.8 21.1 31.8 29.5 30.6 39.7 59.4 16.6 4.6 2.1 2.2 4.0 1.8 2.8 3.1 2.9 4.9 2.4 1.5 2.4 3.6 0.0 1.7 1.5 5.0 1.4 3.6 20.0 30.8 38.9 33.5 15.7 26.2 62.3 40.7 65.7 28.4 40.4 58.7 13.8 12.8 36.8 66.6 7.2 37.0 3.8 30.2 8.0 16.0 15.3 8.0 13.7 14.3 18.7 11.0 4.2 3.7 11.8 10.4 0.0 10.5 6.5 6.6 16.4 10.3 19.7 16.8 21.2 17.2 6.7 19.7 13.3 14.6 3.8 20.6 11.4 132.0 9.7 23.5 24.2 11.6 16.2 7.5 13.7 6.6 21.1 4.9 21.4 21.5 12.0 7.5 5.2 22.1 158.8 14.0 2.7 13.5 6.3 16.2 5.0 4.1 11.0 16.4 0.0 9.8 8.5 20.3 18.1 12.6 54.0 6.3 7.9 18.0 10.9 4.6 MSMO1 "DESP4, ERG25, SC4MOL" ENSG00000052802 "Methylsterol monooxygenase 1" Q15800 4 165327667-165343164 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Oxidoreductase "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 575.6" "Cell type enhanced" "Detected in all" "Hepatocytes: 532.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "GAMG: 416.2;Karpas-707: 412.3;RPTEC TERT1: 399.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA055073, HPA056127" Enhanced Approved "Endoplasmic reticulum" NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 85: Liver - Metabolism" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 15: Hepatocytes - Hemostasis" "Endoplasmic reticulum" "HPA055073: , HPA056127: AB_2683045" "unprognostic (5.76e-2)" "prognostic unfavorable (2.97e-4)" "unprognostic (3.35e-2)" "unprognostic (7.85e-2)" "unprognostic (1.74e-1)" "unprognostic (1.20e-2)" "unprognostic (7.14e-2)" "unprognostic (1.75e-2)" "unprognostic (3.52e-2)" "unprognostic (2.06e-1)" "unprognostic (3.22e-3)" "unprognostic (2.28e-1)" "prognostic favorable (9.21e-4)" "unprognostic (2.39e-1)" "unprognostic (1.56e-2)" "unprognostic (3.54e-1)" "unprognostic (1.40e-1)" 18.3 95.2 36.7 20.9 48.2 10.4 66.2 45.1 47.5 57.1 37.4 39.2 75.7 19.1 97.0 145.7 20.9 21.7 18.5 43.9 59.2 52.6 575.6 70.3 20.7 90.5 58.4 25.7 22.6 42.9 18.4 22.9 78.6 58.9 32.9 26.1 34.7 12.1 5.5 82.5 38.1 16.5 45.0 11.0 31.5 52.8 48.4 13.4 22.4 6.5 27.0 20.2 67.0 61.1 89.1 21.7 198.8 36.4 97.7 312.0 37.5 35.3 159.0 44.7 123.4 41.5 372.9 43.4 20.6 43.1 416.2 71.7 101.6 366.3 49.4 37.7 63.0 20.0 20.0 127.6 194.9 35.8 26.8 192.6 237.6 163.6 100.6 61.1 58.8 55.7 35.3 412.3 74.6 45.7 32.6 58.2 115.6 46.9 21.0 16.8 21.8 132.3 399.5 102.5 39.7 30.0 54.5 77.9 33.9 121.7 36.1 44.7 67.6 20.6 36.1 18.5 24.7 75.9 86.5 58.6 43.9 36.0 28.5 13.7 8.6 8.8 34.0 11.6 25.4 40.6 31.8 31.4 15.0 37.6 34.3 35.6 6.1 24.9 20.5 19.3 31.0 29.2 36.7 48.2 45.1 47.5 43.9 59.2 90.5 58.4 78.6 45.0 48.4 61.1 16.9 51.3 168.0 70.5 28.9 36.1 70.1 189.2 21.6 33.8 81.9 23.0 10.7 40.0 160.0 69.9 27.1 55.6 20.7 130.8 35.2 67.9 6.4 27.6 12.2 30.4 60.7 53.9 33.6 71.7 87.0 24.1 35.2 44.4 47.7 83.0 27.8 532.0 28.3 35.3 22.8 72.8 170.9 28.0 11.5 7.0 24.8 18.3 32.0 10.3 23.6 27.2 17.5 42.7 49.6 86.8 85.7 18.8 10.9 138.3 46.0 38.4 103.2 50.4 19.7 5.6 35.1 8.7 15.4 84.6 115.1 123.0 22.3 136.1 36.9 129.0 MVD MPD ENSG00000167508 "Mevalonate diphosphate decarboxylase" P53602 16 88651935-88663161 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Lyase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hepatocytes: 147.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041404, HPA048250" Uncertain Approved "Cell Junctions,Cytosol" NA NA 170000 "Cluster 15: NK-cells - Transcription" "Cluster 37: Intestine - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 15: Hepatocytes - Hemostasis" Cytosol "Cell Junctions" "HPA041404: AB_2677457, HPA048250: AB_2680329" "unprognostic (1.67e-1)" "unprognostic (3.05e-1)" "unprognostic (2.42e-1)" "prognostic favorable (2.17e-4)" "unprognostic (1.89e-1)" "unprognostic (9.56e-2)" "unprognostic (9.26e-3)" "unprognostic (8.33e-2)" "unprognostic (6.68e-2)" "unprognostic (5.47e-2)" "unprognostic (2.51e-1)" "unprognostic (6.22e-2)" "unprognostic (1.19e-3)" "unprognostic (4.12e-2)" "unprognostic (1.69e-1)" "unprognostic (2.11e-1)" "unprognostic (5.00e-2)" 20.3 51.1 24.2 15.7 27.5 7.0 16.4 26.2 37.5 30.5 19.3 32.3 35.1 20.3 2.2 77.8 13.5 4.9 22.8 24.7 27.8 28.8 78.8 31.0 12.3 32.4 27.8 19.6 25.3 8.3 18.9 6.3 39.3 23.5 4.2 3.4 25.1 6.5 27.2 52.3 26.6 5.7 24.0 24.6 31.5 42.3 24.7 7.0 21.1 8.3 6.8 17.6 36.9 25.6 50.6 34.2 52.4 33.1 18.1 38.7 29.5 25.1 26.0 17.7 14.6 86.1 119.7 24.4 39.8 15.7 63.7 72.8 25.0 133.1 4.9 15.7 38.3 17.8 18.2 127.0 35.9 11.6 11.8 30.9 24.6 46.6 13.5 8.7 18.0 58.0 51.7 13.1 10.2 115.9 39.3 56.6 61.5 17.7 31.3 40.2 15.0 62.3 49.8 33.0 52.2 17.9 62.0 13.3 18.5 11.4 67.8 51.3 39.0 14.7 29.8 27.2 14.2 34.9 17.6 83.2 17.9 55.7 25.7 5.6 12.6 2.4 26.8 13.7 20.4 16.1 18.0 17.9 15.0 22.6 13.2 16.6 1.8 28.3 15.4 28.0 20.4 15.4 24.2 27.5 26.2 37.5 24.7 27.8 32.4 27.8 39.3 24.0 24.7 25.6 17.2 25.6 48.2 22.2 21.5 15.2 12.9 106.3 4.0 27.2 26.5 14.1 16.7 21.5 56.9 20.2 6.2 20.2 79.6 117.5 25.4 30.8 61.6 17.7 10.0 15.8 32.9 26.5 23.4 62.3 29.2 15.5 41.8 26.5 16.5 27.4 20.7 147.2 38.6 23.5 17.0 75.3 32.6 25.5 21.6 96.2 8.1 20.3 21.4 6.5 32.2 16.5 55.6 11.1 14.5 30.0 79.4 9.1 46.3 20.1 47.1 22.6 21.5 18.1 6.6 7.0 20.7 50.8 13.0 13.8 21.6 48.8 36.3 35.5 65.2 20.6 MVK "LRBP, MK" ENSG00000110921 "Mevalonate kinase" Q03426 12 109573255-109598125 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" "Kinase, Transferase" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 69.1" "Cell type enhanced" "Detected in all" "Early spermatids: 60.5;Horizontal cells: 62.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016961, HPA044110" Approved Supported Vesicles,Cytosol NA NA "Cluster 24: B-cells - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 15: Hepatocytes - Hemostasis" "Vesicles, Cytosol" "HPA016961: AB_1854220, HPA044110: " "unprognostic (3.10e-1)" "unprognostic (2.27e-2)" "unprognostic (1.85e-1)" "unprognostic (4.43e-2)" "unprognostic (3.66e-2)" "unprognostic (2.08e-2)" "unprognostic (4.30e-2)" "unprognostic (8.98e-2)" "unprognostic (1.05e-1)" "unprognostic (2.73e-2)" "unprognostic (8.23e-2)" "unprognostic (1.30e-1)" "unprognostic (6.43e-2)" "unprognostic (2.09e-1)" "unprognostic (1.58e-1)" "unprognostic (3.88e-1)" "unprognostic (3.28e-1)" 7.9 29.8 12.7 6.1 13.7 8.3 14.7 16.7 15.0 14.5 9.6 11.2 13.9 7.3 10.2 45.5 6.3 5.3 9.4 11.1 13.2 32.1 69.1 11.4 6.9 36.1 15.5 10.7 10.0 11.5 11.6 5.4 38.6 12.3 8.6 7.3 13.7 7.0 12.1 33.3 9.8 5.0 15.3 6.7 11.8 28.5 15.3 4.2 15.1 8.8 9.1 9.5 20.1 24.4 30.1 25.0 29.9 13.7 11.2 27.3 14.4 9.5 21.7 30.0 32.8 31.4 33.8 17.7 7.8 11.7 48.1 36.0 31.6 50.0 13.2 19.0 18.1 9.9 15.7 53.7 31.5 11.1 13.0 27.2 42.1 48.8 13.6 12.6 20.9 19.0 18.7 17.4 13.6 34.5 12.0 34.6 22.6 14.9 32.3 10.5 22.1 37.0 67.4 40.9 25.1 18.7 19.8 58.7 14.0 11.0 59.7 21.1 14.1 13.2 14.5 12.0 12.8 13.3 20.6 28.2 16.1 29.2 16.6 1.0 6.9 4.0 12.6 6.5 11.3 9.4 7.4 12.4 8.6 14.1 10.9 8.3 1.6 11.0 4.6 7.0 7.6 6.4 12.7 13.7 16.7 15.0 11.1 13.2 36.1 15.5 38.6 15.3 15.3 24.4 6.1 12.8 12.4 6.8 8.3 4.7 5.2 39.7 4.6 12.4 13.1 11.0 5.7 11.5 25.8 14.7 18.8 33.0 7.3 10.4 21.5 15.6 60.5 5.8 2.3 7.1 9.0 4.8 5.1 18.1 15.3 6.8 9.7 5.1 1.3 14.7 6.4 32.7 15.6 62.2 5.2 7.8 10.2 3.4 2.2 42.5 8.1 4.8 7.2 3.7 10.3 10.6 10.3 4.0 15.3 13.2 3.2 7.2 4.1 5.5 16.4 52.4 13.5 12.2 6.6 4.0 8.2 33.9 16.8 12.0 8.5 47.9 6.1 44.8 11.1 4.6 NSDHL "H105e3, SDR31E1, XAP104" ENSG00000147383 "NAD(P) dependent steroid dehydrogenase-like" Q15738 X 152830967-152869729 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Oxidoreductase "Disease variant, Ichthyosis, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 53.0;Hepatocytes: 55.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000248, HPA000571" Enhanced Enhanced "Endoplasmic reticulum,Lipid droplets" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 37: Intestine - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Endoplasmic reticulum" "Lipid droplets" "HPA000248: AB_1079507, HPA000571: AB_1079506" "unprognostic (1.84e-1)" "prognostic favorable (5.65e-4)" "unprognostic (2.66e-1)" "unprognostic (1.81e-1)" "unprognostic (1.03e-1)" "unprognostic (1.33e-1)" "prognostic unfavorable (5.04e-4)" "unprognostic (1.03e-1)" "unprognostic (5.70e-2)" "unprognostic (4.32e-2)" "unprognostic (5.62e-2)" "unprognostic (2.63e-1)" "prognostic favorable (6.09e-5)" "unprognostic (3.53e-2)" "unprognostic (1.36e-1)" "unprognostic (3.91e-2)" "unprognostic (4.79e-2)" 24.0 38.8 13.2 10.2 12.6 8.9 20.2 14.2 13.3 20.3 13.7 13.9 17.6 13.6 44.5 51.7 14.9 7.9 22.4 13.7 14.3 14.9 50.4 12.9 9.1 16.8 15.4 10.3 10.6 12.9 8.8 10.3 18.5 14.8 13.5 10.4 16.7 21.3 10.1 22.6 24.2 12.5 13.4 9.5 13.8 8.9 15.2 9.9 13.3 10.9 18.1 12.1 24.1 15.1 135.6 48.9 65.5 33.8 54.9 41.5 36.2 26.3 35.2 46.9 59.3 68.5 71.7 67.0 86.0 35.9 174.2 67.6 85.5 122.1 41.3 22.0 49.5 27.9 44.7 70.3 39.8 27.6 21.1 51.1 46.3 92.2 23.0 20.2 44.2 28.7 46.4 29.1 36.1 60.1 27.3 35.8 26.0 67.4 58.1 19.9 47.4 54.6 98.9 55.7 23.4 26.5 23.4 34.6 28.4 44.9 23.1 35.0 38.7 21.6 35.4 52.3 51.0 40.9 29.4 114.9 40.0 42.4 20.8 21.0 19.6 18.7 16.3 18.7 16.4 19.1 16.1 14.1 19.4 15.1 11.6 12.7 2.2 19.7 14.2 17.4 20.4 15.2 13.2 12.6 14.2 13.3 13.7 14.3 16.8 15.4 18.5 13.4 15.2 15.1 7.1 12.8 16.7 5.9 6.3 10.8 12.8 53.0 10.8 4.3 11.7 6.1 25.0 15.7 29.0 12.9 0.0 21.5 6.1 9.6 9.8 20.1 13.3 15.5 6.6 9.2 6.0 13.0 2.2 20.3 22.0 9.0 8.2 15.5 8.2 14.0 7.5 55.0 18.6 1.7 2.2 10.2 26.4 8.7 9.6 8.0 8.4 7.9 5.4 1.0 11.0 10.6 7.2 2.5 5.7 21.4 11.9 9.1 11.3 10.4 25.2 16.5 25.4 6.2 0.0 5.9 12.5 3.7 7.8 19.4 12.1 18.6 5.3 25.1 11.2 16.4 PMVK "HUMPMKI, PMK, PMKA" ENSG00000163344 "Phosphomevalonate kinase" Q15126 1 154924740-154936719 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" "Kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal tubular cells: 266.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029900 Approved NA NA 15000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 2: Karpas-707 - Immune response" "Cluster 47: Cytotrophoblasts - Unknown function" "HPA029900: AB_10601390" "unprognostic (2.52e-1)" "unprognostic (3.68e-2)" "unprognostic (1.25e-2)" "unprognostic (1.32e-1)" "unprognostic (2.31e-1)" "unprognostic (1.81e-2)" "unprognostic (8.13e-2)" "unprognostic (5.47e-2)" "unprognostic (8.22e-2)" "prognostic favorable (9.70e-4)" "unprognostic (1.41e-1)" "unprognostic (8.76e-2)" "prognostic favorable (4.96e-4)" "unprognostic (2.07e-1)" "unprognostic (1.67e-1)" "unprognostic (1.78e-1)" "unprognostic (2.10e-1)" 39.9 56.4 99.0 29.8 100.1 15.3 35.0 97.9 108.9 33.4 95.0 39.9 45.9 25.9 17.7 77.7 37.2 17.2 63.1 93.9 96.4 53.8 91.9 30.1 34.6 98.6 97.4 35.8 41.6 58.2 60.3 23.7 96.0 32.4 22.2 19.8 34.0 27.1 79.1 69.2 44.2 27.7 96.4 45.7 40.5 26.6 102.3 27.9 31.5 47.4 36.8 31.9 37.9 99.8 51.8 72.9 46.7 72.5 43.6 30.9 48.5 40.5 29.3 38.9 37.0 30.6 101.0 75.1 75.9 49.3 40.5 49.4 65.3 63.9 17.8 103.3 28.9 34.1 104.1 29.0 40.0 51.4 29.3 36.3 58.7 70.2 49.6 19.5 40.0 65.9 36.8 221.7 41.3 108.3 40.8 51.0 41.0 121.7 95.0 60.3 29.8 171.1 66.1 38.4 37.7 91.1 44.1 75.7 51.9 35.0 146.7 91.1 32.7 35.8 29.2 84.4 62.1 174.0 153.2 131.8 58.9 83.9 46.7 28.0 80.9 91.8 68.2 205.6 110.1 114.8 93.1 70.6 93.6 111.1 59.1 59.1 6.9 59.7 219.4 96.5 134.3 80.0 99.0 100.1 97.9 108.9 93.9 96.4 98.6 97.4 96.0 96.4 102.3 99.8 22.7 57.7 37.5 9.4 42.2 69.8 105.9 95.8 51.8 38.5 67.1 68.3 57.3 78.6 42.2 53.3 8.4 235.7 31.5 65.0 266.1 69.6 9.0 45.0 28.5 29.8 66.4 35.6 5.1 71.3 108.1 45.1 46.9 44.2 22.2 49.8 39.3 146.9 141.0 37.0 7.0 78.9 67.1 67.9 49.5 13.5 42.6 47.8 65.8 3.7 49.5 119.1 41.2 8.0 11.8 61.7 61.7 47.8 58.8 53.7 219.3 246.1 22.1 27.4 32.9 46.0 48.4 51.3 51.3 81.0 90.5 227.7 45.1 162.6 79.9 76.2 SC5D SC5DL ENSG00000109929 Sterol-C5-desaturase O75845 11 121292681-121313410 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Oxidoreductase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 393.6" "Cell type enhanced" "Detected in all" "Hepatic stellate cells: 141.0;Hepatocytes: 307.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA066283, HPA070248" Enhanced Approved "Nucleoplasm,Endoplasmic reticulum,Plasma membrane,Cytosol" No No "Cluster 44: Non-specific - Transcription" "Cluster 85: Liver - Metabolism" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 15: Hepatocytes - Hemostasis" "Nucleoplasm, Endoplasmic reticulum" "Plasma membrane, Cytosol" "HPA066283: AB_2685648, HPA070248: AB_2686240" "unprognostic (4.78e-2)" "unprognostic (7.29e-2)" "unprognostic (2.26e-2)" "unprognostic (2.36e-1)" "unprognostic (3.98e-2)" "prognostic unfavorable (3.30e-4)" "unprognostic (2.79e-2)" "unprognostic (7.96e-2)" "prognostic unfavorable (3.98e-4)" "unprognostic (4.03e-2)" "unprognostic (3.18e-2)" "unprognostic (1.01e-1)" "prognostic favorable (1.07e-7)" "unprognostic (4.29e-2)" "unprognostic (2.51e-1)" "unprognostic (2.29e-1)" "unprognostic (1.98e-1)" 28.6 35.3 18.4 12.6 20.4 5.7 56.6 37.1 29.3 20.7 17.6 23.2 48.2 15.1 73.2 39.6 16.5 18.2 22.0 19.9 29.9 49.1 393.6 24.6 13.5 42.9 28.0 16.9 21.5 48.6 15.6 14.7 39.1 101.4 19.9 29.5 22.4 56.6 7.7 13.8 24.7 16.2 32.2 8.8 21.7 24.3 24.6 13.5 23.9 13.0 19.5 21.5 27.1 36.5 26.5 14.3 184.8 39.5 72.1 59.9 27.8 27.8 53.5 18.2 32.4 83.1 95.9 25.4 89.0 32.3 156.6 100.8 59.2 70.9 18.1 12.5 80.0 34.6 73.4 64.4 57.9 24.8 12.5 51.0 57.4 60.4 60.2 15.6 29.8 22.8 25.0 34.6 89.0 27.4 9.4 29.2 59.8 74.4 39.7 13.2 51.0 21.6 133.6 116.5 51.1 28.8 73.4 14.6 38.0 125.4 62.2 38.6 58.3 19.0 29.7 32.5 14.0 6.4 11.2 33.3 7.0 49.5 33.5 7.8 3.7 1.0 3.5 4.9 5.9 4.4 4.7 4.2 6.5 4.1 6.8 6.7 0.3 5.3 3.6 7.7 5.5 2.6 18.4 20.4 37.1 29.3 19.9 29.9 42.9 28.0 39.1 32.2 24.6 36.5 10.4 19.2 31.9 23.8 62.6 9.7 49.9 48.9 14.8 26.8 33.7 12.4 20.8 18.6 40.8 20.2 31.3 15.9 47.5 26.4 5.9 24.1 3.0 11.5 8.8 15.7 14.4 18.1 29.6 28.9 16.7 16.3 18.3 19.6 17.7 11.1 141.0 307.1 21.0 23.5 29.4 15.3 59.0 22.1 17.0 1.3 19.3 17.6 19.6 20.6 15.6 38.7 13.4 27.6 34.0 19.3 18.8 17.0 20.9 50.1 24.1 15.8 18.7 28.3 13.1 12.9 14.7 6.7 12.7 36.2 15.5 18.6 56.5 42.8 13.3 54.4 SQLE ENSG00000104549 "Squalene epoxidase" Q14534 8 124998497-125022283 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Oxidoreductase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018038, HPA020762" Enhanced Uncertain Vesicles,Cytosol NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 37: Intestine - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Vesicles, Cytosol" "HPA018038: AB_2669753, HPA020762: AB_2670512" "unprognostic (1.37e-2)" "unprognostic (6.26e-3)" "unprognostic (5.12e-2)" "unprognostic (9.51e-3)" "unprognostic (4.63e-1)" "prognostic unfavorable (7.42e-4)" "unprognostic (4.76e-3)" "prognostic unfavorable (4.67e-4)" "unprognostic (3.45e-2)" "unprognostic (7.21e-2)" "prognostic unfavorable (2.73e-4)" "unprognostic (7.51e-2)" "prognostic unfavorable (5.70e-4)" "unprognostic (9.71e-2)" "unprognostic (4.62e-2)" "unprognostic (1.19e-3)" "unprognostic (7.74e-3)" 8.6 31.1 17.5 19.6 27.0 23.0 22.1 26.8 24.0 30.7 25.4 21.6 31.0 16.4 9.1 78.7 18.6 10.7 7.2 18.6 24.4 17.1 72.3 30.9 17.7 47.3 27.7 14.3 10.7 22.7 16.5 47.5 35.1 25.0 18.6 17.8 19.1 7.6 1.4 49.4 14.0 12.3 27.6 9.7 21.8 59.4 21.8 14.2 10.5 1.6 29.4 14.7 46.2 34.6 135.5 51.5 301.6 87.2 91.7 154.1 30.5 34.9 106.3 46.5 84.7 70.6 192.3 92.7 49.2 43.2 186.0 101.0 127.3 192.4 53.6 77.1 268.3 265.2 32.6 181.1 134.6 31.5 74.6 106.1 201.4 138.8 113.3 29.8 51.5 64.2 153.8 174.8 38.1 223.7 109.6 39.3 125.2 92.6 35.2 47.5 55.4 126.6 329.3 153.3 93.9 47.6 71.6 226.3 74.1 96.5 60.7 81.3 50.8 19.2 66.0 22.9 31.6 31.6 69.6 126.6 32.0 93.7 33.8 1.5 6.3 0.7 10.6 10.8 5.0 16.6 6.0 9.5 15.2 17.1 8.2 8.6 0.2 12.6 12.7 10.8 7.1 7.7 17.5 27.0 26.8 24.0 18.6 24.4 47.3 27.7 35.1 27.6 21.8 34.6 13.2 60.9 97.9 21.5 34.7 22.9 64.0 199.9 16.5 41.8 35.6 27.3 6.1 31.5 129.6 53.3 50.1 99.7 20.6 81.6 7.9 60.3 21.0 95.9 23.3 39.7 31.7 22.3 14.3 83.6 133.7 35.3 51.0 80.5 41.3 77.1 9.7 127.9 61.1 148.0 18.8 58.0 126.1 10.9 30.1 13.2 23.9 22.2 21.4 13.1 91.0 24.3 8.2 20.1 77.9 98.6 38.4 10.9 30.6 118.0 17.3 3.7 123.0 61.1 26.3 12.5 42.0 179.5 128.6 69.5 89.1 217.1 21.1 171.8 35.0 114.8 TM7SF2 "ANG1, DHCR14A, NET47" ENSG00000149809 "Transmembrane 7 superfamily member 2" O76062 11 65111845-65116384 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 246.0" "Cell type enhanced" "Detected in all" "Granulosa cells: 482.7;Hepatocytes: 220.6;Muller glia cells: 204.7;Theca cells: 204.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "plasmacytoid DC: 38.1" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "MCF7: 69.2;RPTEC TERT1: 86.2;T-47d: 143.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030691, HPA072704" Enhanced Supported "Endoplasmic reticulum,Vesicles" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 35: Non-specific - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 40: Granulosa cells - Unknown function" "Endoplasmic reticulum" Vesicles "HPA030691: AB_10602480, HPA072704: AB_2686551" "unprognostic (1.62e-1)" "unprognostic (5.23e-2)" "unprognostic (1.70e-2)" "unprognostic (1.78e-1)" "unprognostic (5.74e-2)" "unprognostic (1.10e-1)" "unprognostic (5.98e-2)" "unprognostic (6.06e-2)" "unprognostic (5.72e-2)" "unprognostic (1.74e-2)" "unprognostic (7.06e-2)" "unprognostic (1.69e-1)" "prognostic favorable (8.49e-8)" "unprognostic (8.77e-2)" "unprognostic (1.90e-1)" "unprognostic (1.35e-1)" "unprognostic (3.44e-2)" 63.4 246.0 27.8 2.6 28.5 4.1 29.1 32.8 33.9 17.4 64.1 7.8 9.4 3.4 17.0 39.6 12.8 7.0 47.3 30.0 29.7 18.9 86.4 10.1 3.4 34.0 32.0 36.5 69.9 36.3 19.5 3.9 32.5 41.1 3.9 6.0 46.9 6.0 7.1 68.2 8.3 1.9 30.1 5.1 35.6 11.5 32.6 5.6 15.5 3.7 8.4 5.5 22.1 35.1 7.7 10.9 27.3 35.1 8.1 1.3 15.4 1.8 4.5 2.7 3.0 26.0 35.8 16.3 26.9 2.2 1.0 13.3 11.6 21.2 1.9 16.7 5.0 10.2 2.7 54.5 18.8 4.2 10.6 3.7 5.0 14.6 3.9 12.6 3.9 28.7 5.8 13.9 0.8 69.2 8.3 18.6 12.6 18.4 11.2 22.4 1.2 39.9 86.2 12.6 27.2 30.5 1.2 28.2 6.1 19.5 143.9 11.4 3.1 0.4 3.4 3.8 2.3 27.1 18.1 8.4 2.5 5.9 1.0 1.1 1.6 3.4 9.1 1.5 7.0 12.4 5.6 7.8 1.5 11.9 11.8 9.0 1.1 12.5 0.9 38.1 5.6 4.9 27.8 28.5 32.8 33.9 30.0 29.7 34.0 32.0 32.5 30.1 32.6 35.1 4.0 9.6 43.7 23.5 12.7 1.9 6.2 33.6 5.7 19.2 52.2 38.5 99.4 52.9 36.6 44.1 10.4 72.9 16.3 23.3 17.6 27.1 28.8 17.9 2.6 5.7 59.4 13.7 11.6 27.7 4.6 4.3 31.1 16.5 7.0 482.7 5.0 220.6 15.6 25.2 15.3 21.8 52.9 6.3 2.7 59.3 9.9 5.8 12.4 2.8 9.4 204.7 7.2 17.1 36.5 21.7 23.7 2.2 12.9 31.3 29.0 77.5 37.9 23.6 13.1 1.6 21.8 13.3 17.9 18.0 7.0 82.1 8.3 204.8 19.0 10.4