[{"Gene":"FASN","Gene synonym":["FAS","SDR27X1"],"Ensembl":"ENSG00000169710","Gene description":"Fatty acid synthase","Uniprot":["P49327"],"Chromosome":"17","Position":"82078338-82098294","Protein class":["Cancer-related genes","Enzymes","FDA approved drug targets","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Fatty acid biosynthesis","Fatty acid metabolism","Lipid biosynthesis","Lipid metabolism"],"Molecular function":["Hydrolase","Lyase","Multifunctional enzyme","Oxidoreductase","Transferase"],"Disease involvement":["Cancer-related genes","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adipose tissue":"372.8","breast":"271.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Alveolar cells type 2":"126.0","Breast glandular cells":"442.9","Breast myoepithelial cells":"165.4","Hepatocytes":"244.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cell line enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"SK-BR-3":"1109.2"},"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB005192","HPA006461","CAB015417","HPA056108"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3400000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Non-specific - Angiogenesis","Cell line expression cluster":"Cluster 8: SK-BR-3 - Unknown function","Single cell expression cluster":"Cluster 30: Mammary glandular cells - Lactation","Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB005192":"AB_2101095","CAB015417":"AB_2231427","HPA006461":"AB_1848437","HPA056108":"AB_2683039"},"Pathology prognostics - Breast cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.35e-2"},"Pathology prognostics - Cervical cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"1.42e-5"},"Pathology prognostics - Colorectal cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.69e-3"},"Pathology prognostics - Endometrial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.09e-2"},"Pathology prognostics - Glioma":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.46e-3"},"Pathology prognostics - Head and neck cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.55e-2"},"Pathology prognostics - Liver cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.09e-2"},"Pathology prognostics - Lung cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.74e-3"},"Pathology prognostics - Melanoma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.15e-1"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.15e-1"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.87e-3"},"Pathology prognostics - Prostate cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.05e-1"},"Pathology prognostics - Renal cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"7.16e-5"},"Pathology prognostics - Stomach cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.50e-2"},"Pathology prognostics - Testis cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.62e-2"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.35e-2"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.03e-3"},"Tissue RNA - adipose tissue [nTPM]":"372.8","Tissue RNA - adrenal gland [nTPM]":"30.9","Tissue RNA - amygdala [nTPM]":"25.0","Tissue RNA - appendix [nTPM]":"14.9","Tissue RNA - basal ganglia [nTPM]":"44.2","Tissue RNA - bone marrow [nTPM]":"18.7","Tissue RNA - breast [nTPM]":"271.6","Tissue RNA - cerebellum [nTPM]":"67.3","Tissue RNA - cerebral cortex [nTPM]":"49.9","Tissue RNA - cervix [nTPM]":"31.7","Tissue RNA - choroid plexus [nTPM]":"0.0","Tissue RNA - colon [nTPM]":"25.5","Tissue RNA - duodenum [nTPM]":"11.5","Tissue RNA - endometrium 1 [nTPM]":"18.0","Tissue RNA - epididymis [nTPM]":"6.2","Tissue RNA - esophagus [nTPM]":"63.6","Tissue RNA - fallopian tube [nTPM]":"15.2","Tissue RNA - gallbladder [nTPM]":"6.6","Tissue RNA - heart muscle [nTPM]":"21.9","Tissue RNA - hippocampal formation [nTPM]":"39.9","Tissue RNA - hypothalamus [nTPM]":"15.0","Tissue RNA - kidney [nTPM]":"11.8","Tissue RNA - liver [nTPM]":"191.4","Tissue RNA - lung [nTPM]":"54.1","Tissue RNA - lymph node [nTPM]":"7.2","Tissue RNA - medulla oblongata [nTPM]":"84.4","Tissue RNA - midbrain [nTPM]":"75.7","Tissue RNA - ovary [nTPM]":"16.3","Tissue RNA - pancreas [nTPM]":"18.6","Tissue RNA - parathyroid gland [nTPM]":"8.5","Tissue RNA - pituitary gland [nTPM]":"72.4","Tissue RNA - placenta [nTPM]":"12.1","Tissue RNA - pons [nTPM]":"101.7","Tissue RNA - prostate [nTPM]":"69.0","Tissue RNA - rectum [nTPM]":"3.0","Tissue RNA - retina [nTPM]":"4.3","Tissue RNA - salivary gland [nTPM]":"38.3","Tissue RNA - seminal vesicle [nTPM]":"14.3","Tissue RNA - skeletal muscle [nTPM]":"27.9","Tissue RNA - skin 1 [nTPM]":"89.4","Tissue RNA - small intestine [nTPM]":"28.8","Tissue RNA - smooth muscle [nTPM]":"5.3","Tissue RNA - spinal cord [nTPM]":"12.5","Tissue RNA - spleen [nTPM]":"8.8","Tissue RNA - stomach 1 [nTPM]":"63.6","Tissue RNA - testis [nTPM]":"11.9","Tissue RNA - thalamus [nTPM]":"33.7","Tissue RNA - thymus [nTPM]":"9.6","Tissue RNA - thyroid gland [nTPM]":"21.2","Tissue RNA - tongue [nTPM]":"2.3","Tissue RNA - tonsil [nTPM]":"3.0","Tissue RNA - urinary bladder [nTPM]":"27.0","Tissue RNA - vagina [nTPM]":"31.8","Tissue RNA - white matter [nTPM]":"60.8","Cell RNA - A-431 [nTPM]":"179.1","Cell RNA - A549 [nTPM]":"182.0","Cell RNA - AF22 [nTPM]":"81.7","Cell RNA - AN3-CA [nTPM]":"56.7","Cell RNA - ASC diff [nTPM]":"130.1","Cell RNA - ASC TERT1 [nTPM]":"87.2","Cell RNA - BEWO [nTPM]":"176.9","Cell RNA - BJ [nTPM]":"34.3","Cell RNA - BJ hTERT+ [nTPM]":"43.3","Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]":"35.5","Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]":"64.6","Cell RNA - CACO-2 [nTPM]":"190.6","Cell RNA - CAPAN-2 [nTPM]":"116.7","Cell RNA - Daudi [nTPM]":"58.8","Cell RNA - EFO-21 [nTPM]":"29.2","Cell RNA - fHDF\/TERT166 [nTPM]":"26.3","Cell RNA - GAMG [nTPM]":"99.5","Cell RNA - HaCaT [nTPM]":"144.0","Cell RNA - HAP1 [nTPM]":"79.2","Cell RNA - HBEC3-KT [nTPM]":"157.8","Cell RNA - HBF TERT88 [nTPM]":"6.5","Cell RNA - HDLM-2 [nTPM]":"30.0","Cell RNA - HEK 293 [nTPM]":"358.0","Cell RNA - HEL [nTPM]":"123.9","Cell RNA - HeLa [nTPM]":"140.0","Cell RNA - Hep G2 [nTPM]":"257.2","Cell RNA - HHSteC [nTPM]":"36.8","Cell RNA - HL-60 [nTPM]":"67.5","Cell RNA - HMC-1 [nTPM]":"19.2","Cell RNA - HSkMC [nTPM]":"84.2","Cell RNA - hTCEpi [nTPM]":"40.4","Cell RNA - hTEC\/SVTERT24-B [nTPM]":"90.8","Cell RNA - hTERT-HME1 [nTPM]":"21.0","Cell RNA - hTERT-RPE1 [nTPM]":"12.1","Cell RNA - HUVEC TERT2 [nTPM]":"40.1","Cell RNA - JURKAT [nTPM]":"54.8","Cell RNA - K-562 [nTPM]":"193.2","Cell RNA - Karpas-707 [nTPM]":"50.7","Cell RNA - LHCN-M2 [nTPM]":"12.6","Cell RNA - MCF7 [nTPM]":"304.1","Cell RNA - MOLT-4 [nTPM]":"78.9","Cell RNA - NB-4 [nTPM]":"105.5","Cell RNA - NTERA-2 [nTPM]":"161.1","Cell RNA - OE19 [nTPM]":"28.1","Cell RNA - PC-3 [nTPM]":"107.1","Cell RNA - REH [nTPM]":"64.1","Cell RNA - RH-30 [nTPM]":"47.8","Cell RNA - RPMI-8226 [nTPM]":"116.5","Cell RNA - RPTEC TERT1 [nTPM]":"40.3","Cell RNA - RT4 [nTPM]":"220.7","Cell RNA - SCLC-21H [nTPM]":"205.0","Cell RNA - SH-SY5Y [nTPM]":"117.0","Cell RNA - SiHa [nTPM]":"50.6","Cell RNA - SK-BR-3 [nTPM]":"1109.2","Cell RNA - SK-MEL-30 [nTPM]":"93.6","Cell RNA - SuSa [nTPM]":"29.5","Cell RNA - T-47d [nTPM]":"199.4","Cell RNA - THP-1 [nTPM]":"123.4","Cell RNA - TIME [nTPM]":"71.1","Cell RNA - U-138 MG [nTPM]":"52.3","Cell RNA - U-2 OS [nTPM]":"107.0","Cell RNA - U-2197 [nTPM]":"45.2","Cell RNA - U-251 MG [nTPM]":"88.4","Cell RNA - U-266\/70 [nTPM]":"68.5","Cell RNA - U-266\/84 [nTPM]":"17.1","Cell RNA - U-698 [nTPM]":"60.6","Cell RNA - U-87 MG [nTPM]":"31.2","Cell RNA - U-937 [nTPM]":"71.1","Cell RNA - WM-115 [nTPM]":"79.5","Blood RNA - basophil [nTPM]":"0.0","Blood RNA - classical monocyte [nTPM]":"0.1","Blood RNA - eosinophil [nTPM]":"0.0","Blood RNA - gdT-cell [nTPM]":"0.1","Blood RNA - intermediate monocyte [nTPM]":"0.0","Blood RNA - MAIT T-cell [nTPM]":"0.1","Blood RNA - memory B-cell [nTPM]":"0.0","Blood RNA - memory CD4 T-cell [nTPM]":"0.2","Blood RNA - memory CD8 T-cell [nTPM]":"0.2","Blood RNA - myeloid DC [nTPM]":"0.2","Blood RNA - naive B-cell [nTPM]":"0.0","Blood RNA - naive CD4 T-cell [nTPM]":"0.1","Blood RNA - naive CD8 T-cell [nTPM]":"0.1","Blood RNA - neutrophil [nTPM]":"0.0","Blood RNA - NK-cell [nTPM]":"0.0","Blood RNA - non-classical monocyte [nTPM]":"0.0","Blood RNA - plasmacytoid DC [nTPM]":"0.1","Blood RNA - T-reg [nTPM]":"0.0","Blood RNA - total PBMC [nTPM]":"0.1","Brain RNA - amygdala [nTPM]":"25.0","Brain RNA - basal ganglia [nTPM]":"44.2","Brain RNA - cerebellum [nTPM]":"67.3","Brain RNA - cerebral cortex [nTPM]":"49.9","Brain RNA - hippocampal formation [nTPM]":"39.9","Brain RNA - hypothalamus [nTPM]":"15.0","Brain RNA - medulla oblongata [nTPM]":"84.4","Brain RNA - midbrain [nTPM]":"75.7","Brain RNA - pons [nTPM]":"101.7","Brain RNA - spinal cord [nTPM]":"12.5","Brain RNA - thalamus [nTPM]":"33.7","Brain RNA - white matter [nTPM]":"60.8","Single Cell Type RNA - Adipocytes [nTPM]":"9.6","Single Cell Type RNA - Alveolar cells type 1 [nTPM]":"25.6","Single Cell Type RNA - Alveolar cells type 2 [nTPM]":"126.0","Single Cell Type RNA - Astrocytes [nTPM]":"28.4","Single Cell Type RNA - B-cells [nTPM]":"7.4","Single Cell Type RNA - Basal keratinocytes [nTPM]":"7.8","Single Cell Type RNA - Basal prostatic cells [nTPM]":"12.7","Single Cell Type RNA - Basal respiratory cells [nTPM]":"33.2","Single Cell Type RNA - Basal squamous epithelial cells [nTPM]":"8.0","Single Cell Type RNA - Bipolar cells [nTPM]":"28.7","Single Cell Type RNA - Breast glandular cells [nTPM]":"442.9","Single Cell Type RNA - Breast myoepithelial cells [nTPM]":"165.4","Single Cell Type RNA - Cardiomyocytes [nTPM]":"5.9","Single Cell Type RNA - Cholangiocytes [nTPM]":"21.5","Single Cell Type RNA - Club cells [nTPM]":"28.4","Single Cell Type RNA - Collecting duct cells [nTPM]":"11.0","Single Cell Type RNA - Cone photoreceptor cells [nTPM]":"6.2","Single Cell Type RNA - Cytotrophoblasts [nTPM]":"32.0","Single Cell Type RNA - dendritic cells [nTPM]":"12.8","Single Cell Type RNA - Distal enterocytes [nTPM]":"35.7","Single Cell Type RNA - Distal tubular cells [nTPM]":"3.9","Single Cell Type RNA - Ductal cells [nTPM]":"19.2","Single Cell Type RNA - Early spermatids [nTPM]":"1.5","Single Cell Type RNA - Endometrial ciliated cells [nTPM]":"19.6","Single Cell Type RNA - Endometrial stromal cells [nTPM]":"19.8","Single Cell Type RNA - Endothelial cells [nTPM]":"10.8","Single Cell Type RNA - Enteroendocrine cells [nTPM]":"18.1","Single Cell Type RNA - Erythroid cells [nTPM]":"20.6","Single Cell Type RNA - Excitatory neurons [nTPM]":"11.9","Single Cell Type RNA - Exocrine glandular cells [nTPM]":"29.2","Single Cell Type RNA - Extravillous trophoblasts [nTPM]":"77.7","Single Cell Type RNA - Fibroblasts [nTPM]":"13.4","Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]":"33.6","Single Cell Type RNA - Glandular and luminal cells [nTPM]":"17.1","Single Cell Type RNA - granulocytes [nTPM]":"12.7","Single Cell Type RNA - Granulosa cells [nTPM]":"29.9","Single Cell Type RNA - Hepatic stellate cells [nTPM]":"10.8","Single Cell Type RNA - Hepatocytes [nTPM]":"244.1","Single Cell Type RNA - Hofbauer cells [nTPM]":"13.9","Single Cell Type RNA - Horizontal cells [nTPM]":"30.3","Single Cell Type RNA - Inhibitory neurons [nTPM]":"12.5","Single Cell Type RNA - Intestinal goblet cells [nTPM]":"22.3","Single Cell Type RNA - Ionocytes [nTPM]":"22.4","Single Cell Type RNA - Kupffer cells [nTPM]":"9.8","Single Cell Type RNA - Langerhans cells [nTPM]":"6.2","Single Cell Type RNA - Late spermatids [nTPM]":"3.4","Single Cell Type RNA - Leydig cells [nTPM]":"16.4","Single Cell Type RNA - Macrophages [nTPM]":"7.0","Single Cell Type RNA - Melanocytes [nTPM]":"17.8","Single Cell Type RNA - Microglial cells [nTPM]":"4.7","Single Cell Type RNA - monocytes [nTPM]":"6.2","Single Cell Type RNA - Muller glia cells [nTPM]":"14.1","Single Cell Type RNA - NK-cells [nTPM]":"8.2","Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]":"11.6","Single Cell Type RNA - Oligodendrocytes [nTPM]":"17.6","Single Cell Type RNA - Pancreatic endocrine cells [nTPM]":"19.1","Single Cell Type RNA - Paneth cells [nTPM]":"23.6","Single Cell Type RNA - Peritubular cells [nTPM]":"11.3","Single Cell Type RNA - Plasma cells [nTPM]":"9.7","Single Cell Type RNA - Prostatic glandular cells [nTPM]":"60.4","Single Cell Type RNA - Proximal enterocytes [nTPM]":"6.5","Single Cell Type RNA - Proximal tubular cells [nTPM]":"5.9","Single Cell Type RNA - Respiratory ciliated cells [nTPM]":"23.7","Single Cell Type RNA - Rod photoreceptor cells [nTPM]":"13.1","Single Cell Type RNA - Sertoli cells [nTPM]":"0.0","Single Cell Type RNA - Skeletal myocytes [nTPM]":"9.0","Single Cell Type RNA - Smooth muscle cells [nTPM]":"14.9","Single Cell Type RNA - Spermatocytes [nTPM]":"1.8","Single Cell Type RNA - Spermatogonia [nTPM]":"11.7","Single Cell Type RNA - Squamous epithelial cells [nTPM]":"34.1","Single Cell Type RNA - Suprabasal keratinocytes [nTPM]":"13.8","Single Cell Type RNA - Syncytiotrophoblasts [nTPM]":"29.6","Single Cell Type RNA - T-cells [nTPM]":"10.6","Single Cell Type RNA - Theca cells [nTPM]":"27.9","Single Cell Type RNA - Undifferentiated cells [nTPM]":"27.4","Single Cell Type RNA - Urothelial cells [nTPM]":"19.6"}]