Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific nTPM" "RNA single cell type specificity" "RNA single cell type distribution" "RNA single cell type specificity score" "RNA single cell type specific nTPM" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific nTPM" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific nTPM" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific nTPM" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific nTPM" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific nTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific nTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "CCD Protein" "CCD Transcript" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Blood expression cluster" "Tissue expression cluster" "Cell line expression cluster" "Single cell expression cluster" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [nTPM]" "Tissue RNA - adrenal gland [nTPM]" "Tissue RNA - amygdala [nTPM]" "Tissue RNA - appendix [nTPM]" "Tissue RNA - basal ganglia [nTPM]" "Tissue RNA - bone marrow [nTPM]" "Tissue RNA - breast [nTPM]" "Tissue RNA - cerebellum [nTPM]" "Tissue RNA - cerebral cortex [nTPM]" "Tissue RNA - cervix [nTPM]" "Tissue RNA - choroid plexus [nTPM]" "Tissue RNA - colon [nTPM]" "Tissue RNA - duodenum [nTPM]" "Tissue RNA - endometrium 1 [nTPM]" "Tissue RNA - epididymis [nTPM]" "Tissue RNA - esophagus [nTPM]" "Tissue RNA - fallopian tube [nTPM]" "Tissue RNA - gallbladder [nTPM]" "Tissue RNA - heart muscle [nTPM]" "Tissue RNA - hippocampal formation [nTPM]" "Tissue RNA - hypothalamus [nTPM]" "Tissue RNA - kidney [nTPM]" "Tissue RNA - liver [nTPM]" "Tissue RNA - lung [nTPM]" "Tissue RNA - lymph node [nTPM]" "Tissue RNA - medulla oblongata [nTPM]" "Tissue RNA - midbrain [nTPM]" "Tissue RNA - ovary [nTPM]" "Tissue RNA - pancreas [nTPM]" "Tissue RNA - parathyroid gland [nTPM]" "Tissue RNA - pituitary gland [nTPM]" "Tissue RNA - placenta [nTPM]" "Tissue RNA - pons [nTPM]" "Tissue RNA - prostate [nTPM]" "Tissue RNA - rectum [nTPM]" "Tissue RNA - retina [nTPM]" "Tissue RNA - salivary gland [nTPM]" "Tissue RNA - seminal vesicle [nTPM]" "Tissue RNA - skeletal muscle [nTPM]" "Tissue RNA - skin 1 [nTPM]" "Tissue RNA - small intestine [nTPM]" "Tissue RNA - smooth muscle [nTPM]" "Tissue RNA - spinal cord [nTPM]" "Tissue RNA - spleen [nTPM]" "Tissue RNA - stomach 1 [nTPM]" "Tissue RNA - testis [nTPM]" "Tissue RNA - thalamus [nTPM]" "Tissue RNA - thymus [nTPM]" "Tissue RNA - thyroid gland [nTPM]" "Tissue RNA - tongue [nTPM]" "Tissue RNA - tonsil [nTPM]" "Tissue RNA - urinary bladder [nTPM]" "Tissue RNA - vagina [nTPM]" "Tissue RNA - white matter [nTPM]" "Cell RNA - A-431 [nTPM]" "Cell RNA - A549 [nTPM]" "Cell RNA - AF22 [nTPM]" "Cell RNA - AN3-CA [nTPM]" "Cell RNA - ASC diff [nTPM]" "Cell RNA - ASC TERT1 [nTPM]" "Cell RNA - BEWO [nTPM]" "Cell RNA - BJ [nTPM]" "Cell RNA - BJ hTERT+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]" "Cell RNA - CACO-2 [nTPM]" "Cell RNA - CAPAN-2 [nTPM]" "Cell RNA - Daudi [nTPM]" "Cell RNA - EFO-21 [nTPM]" "Cell RNA - fHDF/TERT166 [nTPM]" "Cell RNA - GAMG [nTPM]" "Cell RNA - HaCaT [nTPM]" "Cell RNA - HAP1 [nTPM]" "Cell RNA - HBEC3-KT [nTPM]" "Cell RNA - HBF TERT88 [nTPM]" "Cell RNA - HDLM-2 [nTPM]" "Cell RNA - HEK 293 [nTPM]" "Cell RNA - HEL [nTPM]" "Cell RNA - HeLa [nTPM]" "Cell RNA - Hep G2 [nTPM]" "Cell RNA - HHSteC [nTPM]" "Cell RNA - HL-60 [nTPM]" "Cell RNA - HMC-1 [nTPM]" "Cell RNA - HSkMC [nTPM]" "Cell RNA - hTCEpi [nTPM]" "Cell RNA - hTEC/SVTERT24-B [nTPM]" "Cell RNA - hTERT-HME1 [nTPM]" "Cell RNA - hTERT-RPE1 [nTPM]" "Cell RNA - HUVEC TERT2 [nTPM]" "Cell RNA - JURKAT [nTPM]" "Cell RNA - K-562 [nTPM]" "Cell RNA - Karpas-707 [nTPM]" "Cell RNA - LHCN-M2 [nTPM]" "Cell RNA - MCF7 [nTPM]" "Cell RNA - MOLT-4 [nTPM]" "Cell RNA - NB-4 [nTPM]" "Cell RNA - NTERA-2 [nTPM]" "Cell RNA - OE19 [nTPM]" "Cell RNA - PC-3 [nTPM]" "Cell RNA - REH [nTPM]" "Cell RNA - RH-30 [nTPM]" "Cell RNA - RPMI-8226 [nTPM]" "Cell RNA - RPTEC TERT1 [nTPM]" "Cell RNA - RT4 [nTPM]" "Cell RNA - SCLC-21H [nTPM]" "Cell RNA - SH-SY5Y [nTPM]" "Cell RNA - SiHa [nTPM]" "Cell RNA - SK-BR-3 [nTPM]" "Cell RNA - SK-MEL-30 [nTPM]" "Cell RNA - SuSa [nTPM]" "Cell RNA - T-47d [nTPM]" "Cell RNA - THP-1 [nTPM]" "Cell RNA - TIME [nTPM]" "Cell RNA - U-138 MG [nTPM]" "Cell RNA - U-2 OS [nTPM]" "Cell RNA - U-2197 [nTPM]" "Cell RNA - U-251 MG [nTPM]" "Cell RNA - U-266/70 [nTPM]" "Cell RNA - U-266/84 [nTPM]" "Cell RNA - U-698 [nTPM]" "Cell RNA - U-87 MG [nTPM]" "Cell RNA - U-937 [nTPM]" "Cell RNA - WM-115 [nTPM]" "Blood RNA - basophil [nTPM]" "Blood RNA - classical monocyte [nTPM]" "Blood RNA - eosinophil [nTPM]" "Blood RNA - gdT-cell [nTPM]" "Blood RNA - intermediate monocyte [nTPM]" "Blood RNA - MAIT T-cell [nTPM]" "Blood RNA - memory B-cell [nTPM]" "Blood RNA - memory CD4 T-cell [nTPM]" "Blood RNA - memory CD8 T-cell [nTPM]" "Blood RNA - myeloid DC [nTPM]" "Blood RNA - naive B-cell [nTPM]" "Blood RNA - naive CD4 T-cell [nTPM]" "Blood RNA - naive CD8 T-cell [nTPM]" "Blood RNA - neutrophil [nTPM]" "Blood RNA - NK-cell [nTPM]" "Blood RNA - non-classical monocyte [nTPM]" "Blood RNA - plasmacytoid DC [nTPM]" "Blood RNA - T-reg [nTPM]" "Blood RNA - total PBMC [nTPM]" "Brain RNA - amygdala [nTPM]" "Brain RNA - basal ganglia [nTPM]" "Brain RNA - cerebellum [nTPM]" "Brain RNA - cerebral cortex [nTPM]" "Brain RNA - hippocampal formation [nTPM]" "Brain RNA - hypothalamus [nTPM]" "Brain RNA - medulla oblongata [nTPM]" "Brain RNA - midbrain [nTPM]" "Brain RNA - pons [nTPM]" "Brain RNA - spinal cord [nTPM]" "Brain RNA - thalamus [nTPM]" "Brain RNA - white matter [nTPM]" "Single Cell Type RNA - Adipocytes [nTPM]" "Single Cell Type RNA - Alveolar cells type 1 [nTPM]" "Single Cell Type RNA - Alveolar cells type 2 [nTPM]" "Single Cell Type RNA - Astrocytes [nTPM]" "Single Cell Type RNA - B-cells [nTPM]" "Single Cell Type RNA - Basal keratinocytes [nTPM]" "Single Cell Type RNA - Basal prostatic cells [nTPM]" "Single Cell Type RNA - Basal respiratory cells [nTPM]" "Single Cell Type RNA - Basal squamous epithelial cells [nTPM]" "Single Cell Type RNA - Bipolar cells [nTPM]" "Single Cell Type RNA - Breast glandular cells [nTPM]" "Single Cell Type RNA - Breast myoepithelial cells [nTPM]" "Single Cell Type RNA - Cardiomyocytes [nTPM]" "Single Cell Type RNA - Cholangiocytes [nTPM]" "Single Cell Type RNA - Club cells [nTPM]" "Single Cell Type RNA - Collecting duct cells [nTPM]" "Single Cell Type RNA - Cone photoreceptor cells [nTPM]" "Single Cell Type RNA - Cytotrophoblasts [nTPM]" "Single Cell Type RNA - dendritic cells [nTPM]" "Single Cell Type RNA - Distal enterocytes [nTPM]" "Single Cell Type RNA - Distal tubular cells [nTPM]" "Single Cell Type RNA - Ductal cells [nTPM]" "Single Cell Type RNA - Early spermatids [nTPM]" "Single Cell Type RNA - Endometrial ciliated cells [nTPM]" "Single Cell Type RNA - Endometrial stromal cells [nTPM]" "Single Cell Type RNA - Endothelial cells [nTPM]" "Single Cell Type RNA - Enteroendocrine cells [nTPM]" "Single Cell Type RNA - Erythroid cells [nTPM]" "Single Cell Type RNA - Excitatory neurons [nTPM]" "Single Cell Type RNA - Exocrine glandular cells [nTPM]" "Single Cell Type RNA - Extravillous trophoblasts [nTPM]" "Single Cell Type RNA - Fibroblasts [nTPM]" "Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]" "Single Cell Type RNA - Glandular and luminal cells [nTPM]" "Single Cell Type RNA - granulocytes [nTPM]" "Single Cell Type RNA - Granulosa cells [nTPM]" "Single Cell Type RNA - Hepatic stellate cells [nTPM]" "Single Cell Type RNA - Hepatocytes [nTPM]" "Single Cell Type RNA - Hofbauer cells [nTPM]" "Single Cell Type RNA - Horizontal cells [nTPM]" "Single Cell Type RNA - Inhibitory neurons [nTPM]" "Single Cell Type RNA - Intestinal goblet cells [nTPM]" "Single Cell Type RNA - Ionocytes [nTPM]" "Single Cell Type RNA - Kupffer cells [nTPM]" "Single Cell Type RNA - Langerhans cells [nTPM]" "Single Cell Type RNA - Late spermatids [nTPM]" "Single Cell Type RNA - Leydig cells [nTPM]" "Single Cell Type RNA - Macrophages [nTPM]" "Single Cell Type RNA - Melanocytes [nTPM]" "Single Cell Type RNA - Microglial cells [nTPM]" "Single Cell Type RNA - monocytes [nTPM]" "Single Cell Type RNA - Muller glia cells [nTPM]" "Single Cell Type RNA - NK-cells [nTPM]" "Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]" "Single Cell Type RNA - Oligodendrocytes [nTPM]" "Single Cell Type RNA - Pancreatic endocrine cells [nTPM]" "Single Cell Type RNA - Paneth cells [nTPM]" "Single Cell Type RNA - Peritubular cells [nTPM]" "Single Cell Type RNA - Plasma cells [nTPM]" "Single Cell Type RNA - Prostatic glandular cells [nTPM]" "Single Cell Type RNA - Proximal enterocytes [nTPM]" "Single Cell Type RNA - Proximal tubular cells [nTPM]" "Single Cell Type RNA - Respiratory ciliated cells [nTPM]" "Single Cell Type RNA - Rod photoreceptor cells [nTPM]" "Single Cell Type RNA - Sertoli cells [nTPM]" "Single Cell Type RNA - Skeletal myocytes [nTPM]" "Single Cell Type RNA - Smooth muscle cells [nTPM]" "Single Cell Type RNA - Spermatocytes [nTPM]" "Single Cell Type RNA - Spermatogonia [nTPM]" "Single Cell Type RNA - Squamous epithelial cells [nTPM]" "Single Cell Type RNA - Suprabasal keratinocytes [nTPM]" "Single Cell Type RNA - Syncytiotrophoblasts [nTPM]" "Single Cell Type RNA - T-cells [nTPM]" "Single Cell Type RNA - Theca cells [nTPM]" "Single Cell Type RNA - Undifferentiated cells [nTPM]" "Single Cell Type RNA - Urothelial cells [nTPM]" AADAC "CES5A1, DAC" ENSG00000114771 "Arylacetamide deacetylase" P22760 3 151814073-151828488 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 224.9;intestine: 241.7;liver: 946.7" "Group enriched" "Detected in some" 8 "Hepatocytes: 687.7;Proximal enterocytes: 460.5" "Cancer enriched" "Detected in many" 22 "liver cancer: 153.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 9.5;ASC diff: 4.2;EFO-21: 4.6;HBEC3-KT: 4.8" "Not detected" "Not detected" "Not detected" "Not detected" HPA002911 Approved NA NA "Cluster 85: Liver - Metabolism" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 2: Hepatocytes - Metabolism" "HPA002911: AB_1078074" "unprognostic (1.26e-1)" "unprognostic (1.82e-2)" "unprognostic (8.11e-2)" "unprognostic (4.41e-2)" "unprognostic (9.23e-2)" "unprognostic (7.82e-2)" "unprognostic (2.15e-1)" "unprognostic (9.89e-2)" "prognostic favorable (5.58e-6)" "prognostic unfavorable (5.02e-4)" "prognostic unfavorable (2.19e-4)" "unprognostic (1.22e-1)" "unprognostic (1.27e-1)" 8.2 224.9 0.0 0.4 0.0 0.0 5.0 0.0 0.1 0.1 0.2 0.3 220.9 0.2 0.0 2.7 0.6 27.4 0.7 0.0 0.0 0.2 946.7 9.1 0.3 0.0 0.1 0.1 36.7 0.0 0.0 1.5 0.0 0.1 0.2 0.0 1.3 0.0 0.0 13.8 241.7 0.0 0.0 0.2 52.3 0.8 0.1 0.4 0.3 0.0 2.5 0.7 0.4 0.0 0.0 9.5 0.0 0.0 4.2 0.1 0.2 0.0 0.0 0.0 0.0 0.8 0.0 0.1 4.6 0.0 0.0 0.2 0.0 4.8 0.0 0.0 0.0 0.0 0.0 0.4 0.4 0.5 0.1 0.1 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.0 0.1 1.0 0.4 0.1 0.3 1.7 0.0 1.7 0.1 1.2 0.2 0.0 0.0 0.0 0.0 0.0 1.7 0.0 2.0 0.9 0.0 0.3 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 6.5 0.0 14.3 0.0 0.7 0.3 0.0 4.4 0.0 0.0 0.0 0.0 1.1 71.4 8.7 0.0 0.0 0.1 0.3 0.0 0.0 0.2 0.3 1.8 0.1 0.7 0.0 2.7 0.0 51.9 0.0 39.3 53.5 0.2 0.0 0.0 5.0 687.7 0.2 0.0 0.0 9.6 0.0 14.8 0.3 0.0 0.0 0.1 3.6 0.0 0.0 0.0 0.0 0.0 0.0 3.9 10.0 0.0 0.1 0.2 460.5 0.0 2.9 0.0 0.0 0.0 3.4 0.0 0.1 1.4 3.4 0.3 0.7 0.3 18.4 0.2 AAK1 "DKFZp686K16132, KIAA1048" ENSG00000115977 "AP2 associated kinase 1" Q2M2I8 2 69457997-69674349 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Endocytosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "parathyroid gland: 89.7" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 777.7;Rod photoreceptor cells: 640.8" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in many" 6 "cerebral cortex: 31.0" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017931, HPA020289" Enhanced Approved "Vesicles,Plasma membrane,Cytosol" NA No "Cluster 14: Monocytes - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 15: RT4 - Unknown function" "Cluster 9: Photoreceptor cells - Phototransduction" "Vesicles, Plasma membrane" Cytosol "HPA017931: AB_1844406, HPA020289: AB_1844407" "unprognostic (2.11e-3)" "unprognostic (3.18e-2)" "unprognostic (3.67e-1)" "unprognostic (1.01e-3)" "unprognostic (5.06e-2)" "unprognostic (4.04e-2)" "unprognostic (4.23e-2)" "unprognostic (1.14e-1)" "unprognostic (3.52e-1)" "prognostic unfavorable (3.19e-4)" "unprognostic (1.24e-1)" "unprognostic (7.65e-2)" "unprognostic (4.18e-2)" "unprognostic (1.30e-1)" "unprognostic (5.40e-2)" "unprognostic (6.76e-3)" "unprognostic (1.18e-1)" 9.1 12.6 0.3 8.1 0.6 12.0 8.1 0.9 31.0 7.1 0.0 7.0 4.6 9.9 9.9 7.4 7.5 5.4 20.4 2.9 0.0 10.5 5.1 10.3 9.0 4.7 2.9 5.5 13.1 89.7 13.7 9.9 3.5 8.6 6.3 28.2 6.7 8.2 13.0 6.3 8.5 7.6 0.0 8.6 12.6 6.7 4.8 13.2 23.4 6.7 7.7 7.8 7.1 4.8 25.1 15.3 14.6 12.3 13.7 14.3 41.0 19.4 16.8 12.0 11.3 15.6 10.0 0.9 4.6 27.6 16.5 11.4 11.7 11.4 27.1 20.6 4.4 13.3 9.0 10.0 11.7 9.5 31.3 12.9 9.6 23.7 30.9 10.2 27.4 12.3 3.2 14.1 22.5 3.7 8.8 5.6 6.4 4.9 8.3 5.8 13.8 2.2 10.0 51.0 4.2 6.6 12.0 8.8 10.2 9.9 5.3 12.9 25.6 26.4 17.5 19.7 19.4 12.9 3.9 1.5 23.0 16.0 19.1 1.4 0.5 0.2 1.4 0.2 1.4 0.1 1.3 1.0 0.3 0.3 1.7 1.5 1.5 1.1 2.2 0.2 1.0 0.5 0.3 0.6 0.9 31.0 2.9 0.0 4.7 2.9 3.5 0.0 4.8 4.8 54.6 35.3 34.2 77.7 13.4 15.9 20.8 15.9 32.5 254.4 42.2 40.9 86.7 102.9 19.3 143.5 777.7 81.6 149.1 130.6 43.0 46.0 23.9 36.6 67.4 56.0 72.1 35.3 265.8 67.4 56.3 29.5 44.9 65.7 21.0 24.4 118.2 38.2 62.4 306.2 327.7 31.6 12.2 128.8 23.5 32.7 38.2 67.1 10.6 156.4 72.7 53.2 252.4 147.8 113.9 55.9 76.3 46.6 57.4 42.1 56.0 90.0 10.7 640.8 19.7 26.7 45.5 46.9 59.3 23.3 9.9 213.3 158.1 33.6 21.7 49.0 AATK "AATYK, AATYK1, KIAA0641, LMR1, LMTK1, PPP1R77" ENSG00000181409 "Apoptosis associated tyrosine kinase" Q6ZMQ8 17 81110487-81166221 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "brain: 184.7" "Cell type enriched" "Detected in many" 5 "Oligodendrocytes: 243.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 11 "neutrophil: 2.0" "Lineage enriched" "Detected in single" 11 "granulocytes: 2.0" "Group enriched" "Detected in some" 6 "CACO-2: 60.1;SH-SY5Y: 17.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA009073 Enhanced Uncertain Mitochondria NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 70: Brain - Nervous system development" "Cluster 39: CACO-2 - Unknown function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Mitochondria "HPA009073: AB_1078076" "unprognostic (3.47e-3)" "unprognostic (3.01e-2)" "unprognostic (1.12e-1)" "unprognostic (1.95e-4)" "unprognostic (1.96e-1)" "unprognostic (1.94e-1)" "unprognostic (7.29e-2)" "unprognostic (9.85e-2)" "unprognostic (6.09e-2)" "unprognostic (4.27e-2)" "unprognostic (2.88e-3)" "unprognostic (2.48e-1)" "unprognostic (4.28e-6)" "unprognostic (1.58e-3)" "unprognostic (1.21e-1)" "unprognostic (1.39e-1)" "unprognostic (4.57e-2)" 3.3 4.2 35.4 3.1 79.2 3.7 2.3 43.4 82.0 2.8 0.0 7.7 30.9 0.9 0.5 1.8 2.8 2.7 3.9 30.6 30.8 1.0 0.9 9.5 0.9 99.2 67.9 0.9 20.6 3.0 17.3 2.0 63.4 5.2 0.5 2.1 5.9 3.3 0.6 4.5 23.7 0.8 38.8 9.7 5.8 0.7 78.4 0.1 2.9 1.0 0.2 2.8 4.2 184.7 0.3 0.5 0.7 4.9 0.0 0.0 0.7 0.1 0.0 0.0 0.0 60.1 0.2 0.0 0.3 0.0 0.0 1.2 0.6 0.0 0.0 0.0 2.0 2.2 3.2 2.8 0.1 0.0 3.9 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 1.4 0.0 6.6 0.0 0.2 0.7 0.6 0.3 2.1 4.1 0.6 0.0 0.2 4.5 17.1 0.2 0.4 2.3 0.2 1.1 2.2 2.1 0.4 0.5 0.4 0.0 0.1 0.0 0.0 0.2 1.3 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.1 0.0 0.0 0.0 0.0 35.4 79.2 43.4 82.0 30.6 30.8 99.2 67.9 63.4 38.8 78.4 184.7 6.3 32.1 20.3 17.0 0.3 0.3 1.0 1.9 0.6 43.0 1.3 5.1 2.2 2.8 0.1 0.0 4.2 0.1 0.5 6.8 0.0 0.6 0.0 0.4 0.2 1.8 1.8 0.0 34.6 1.8 0.1 0.5 7.1 0.6 6.3 2.0 1.1 0.1 2.1 21.9 36.0 4.6 0.0 2.8 0.4 0.0 1.5 8.2 5.4 2.8 1.5 9.6 4.1 21.1 243.2 1.1 4.2 2.6 0.1 0.9 34.1 0.9 0.0 4.4 0.0 4.3 0.8 0.4 0.5 0.0 0.3 2.3 1.4 0.4 7.0 0.2 ACE "ACE1, CD143, DCP1" ENSG00000159640 "Angiotensin I converting enzyme" P12821 17 63477061-63498380 "Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 265.1;testis: 101.9" "Group enriched" "Detected in many" 20 "Early spermatids: 543.6;Late spermatids: 1322.9;Proximal enterocytes: 1172.8" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "basal ganglia: 8.1" "Immune cell enhanced" "Detected in single" "memory B-cell: 1.0" "Low lineage specificity" "Detected in single" "Group enriched" "Detected in many" 4 "ASC TERT1: 63.3;HUVEC TERT2: 33.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002426, CAB002921, HPA029298, HPA069790" Enhanced Approved Vesicles "Secreted to blood" NA NA 104000000 170000000 "Cluster 43: B-cells - Humoral immune response" "Cluster 56: Intestine - Transmembrane transport" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 45: Enterocytes - Digestion" Vesicles "CAB002426: AB_442052, CAB002921: , HPA029298: AB_10960255, HPA069790: AB_2686197" "unprognostic (4.72e-2)" "unprognostic (4.16e-1)" "unprognostic (1.93e-3)" "unprognostic (6.06e-2)" "unprognostic (2.78e-1)" "unprognostic (1.35e-2)" "unprognostic (4.37e-1)" "unprognostic (1.54e-1)" "unprognostic (1.56e-1)" "unprognostic (1.25e-2)" "unprognostic (3.13e-2)" "unprognostic (2.38e-1)" "unprognostic (7.66e-2)" "unprognostic (9.07e-2)" "unprognostic (1.66e-1)" "unprognostic (1.08e-1)" "unprognostic (2.76e-2)" 13.4 4.9 1.7 4.8 8.1 0.1 8.1 0.2 2.5 18.1 0.5 11.2 176.4 8.1 3.5 4.1 6.3 8.2 10.4 1.3 1.0 10.8 1.9 49.0 4.9 1.3 0.9 1.9 6.2 18.7 9.2 11.6 1.3 8.9 6.1 0.4 7.6 23.8 16.1 3.8 265.1 9.6 0.8 2.8 8.3 101.9 2.0 0.8 19.2 10.0 2.1 5.5 3.8 1.1 0.0 0.0 0.0 0.0 2.6 63.3 0.6 2.4 4.7 0.0 0.0 0.9 5.1 1.3 1.8 11.4 0.1 0.0 3.1 0.0 0.0 0.0 1.4 6.6 0.0 0.0 1.4 0.0 0.0 4.2 0.0 0.1 0.0 1.2 33.8 0.0 5.8 0.0 0.1 1.1 0.0 1.4 0.4 11.7 0.7 0.1 0.5 0.9 0.0 0.0 8.2 5.6 0.0 0.0 0.0 1.3 2.9 0.4 0.0 0.1 0.2 0.5 0.1 0.0 0.0 0.0 1.0 0.0 0.5 0.0 0.0 0.0 0.1 0.1 0.2 1.0 0.5 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 1.7 8.1 0.2 2.5 1.3 1.0 1.3 0.9 1.3 0.8 2.0 1.1 50.0 0.0 3.3 0.0 0.5 1.5 2.6 0.1 1.2 4.0 3.6 1.9 2.1 1.5 0.7 0.0 0.0 0.1 0.3 11.9 0.0 5.9 543.6 10.8 8.0 34.7 18.0 0.0 4.7 0.4 0.1 11.5 2.0 36.3 7.0 24.1 3.6 0.8 4.2 0.0 1.8 39.8 0.0 33.7 3.5 1322.9 4.4 13.6 3.6 4.7 0.0 1.8 0.0 1.0 0.2 0.7 40.9 2.6 0.1 4.2 1172.8 21.7 0.0 1.1 0.0 2.0 4.2 13.5 6.4 0.2 0.1 0.1 2.2 0.3 26.2 2.1 ACE2 ENSG00000130234 "Angiotensin I converting enzyme 2" Q9BYF1 X 15494566-15607236 "Enzymes, Metabolic proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters" "Host-virus interaction" "Carboxypeptidase, Host cell receptor for virus entry, Hydrolase, Metalloprotease, Protease, Receptor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 65.5;intestine: 242.2;kidney: 87.6" "Cell type enriched" "Detected in many" 5 "Proximal enterocytes: 294.8" "Group enriched" "Detected in many" 4 "colorectal cancer: 13.9;renal cancer: 26.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "NB-4: 1.2;NTERA-2: 1.2;SuSa: 1.9" "Low region specificity" "Detected in all" "Not detected" "Not detected" "HPA000288, CAB026174, CAB026213, CAB080024, CAB080025, CAB080027, CAB080028" Enhanced "Secreted to blood" NA NA 400000 "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 5: NTERA-2 - Transcription" "Cluster 45: Enterocytes - Digestion" "CAB026174: , CAB026213: , CAB080024: AB_10864415, CAB080025: AB_2809589, CAB080027: AB_2665870, CAB080028: AB_2665871, HPA000288: AB_1078160" "unprognostic (1.40e-1)" "unprognostic (7.26e-2)" "unprognostic (2.76e-2)" "unprognostic (5.71e-2)" "unprognostic (2.51e-1)" "unprognostic (5.26e-2)" "prognostic favorable (4.21e-4)" "unprognostic (2.34e-2)" "unprognostic (6.74e-3)" "unprognostic (2.54e-3)" "unprognostic (1.00e-1)" "unprognostic (1.74e-1)" "prognostic favorable (2.12e-5)" "unprognostic (1.94e-1)" "unprognostic (9.62e-2)" "unprognostic (2.11e-1)" "unprognostic (7.10e-2)" 8.9 0.5 0.1 1.4 0.1 0.6 4.3 0.4 0.3 0.6 1.9 9.9 183.3 0.5 0.5 1.8 1.5 65.5 42.7 0.2 0.2 87.6 5.7 0.8 0.4 0.2 0.2 1.8 2.5 1.5 0.1 1.2 0.2 0.4 5.9 0.3 1.4 4.1 0.7 0.3 242.2 0.5 0.1 0.1 2.6 49.7 0.2 0.5 4.5 0.5 0.2 0.8 1.2 0.2 0.0 0.0 0.3 0.0 0.2 0.0 0.8 0.1 0.0 0.2 0.2 0.2 0.3 0.4 0.3 0.0 0.3 0.7 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.1 0.0 0.1 0.0 0.2 0.0 0.5 1.2 1.2 0.0 0.0 0.3 0.2 0.5 0.2 0.4 0.2 0.9 0.0 0.4 0.0 1.9 0.4 0.4 0.1 0.0 0.0 0.3 0.4 0.1 0.5 0.5 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.2 0.1 0.1 0.4 0.3 0.2 0.2 0.2 0.2 0.2 0.1 0.2 0.2 0.4 0.0 0.5 1.3 1.4 0.1 0.5 5.0 0.0 0.0 1.6 0.0 11.2 55.8 2.6 0.0 0.0 4.2 0.1 22.9 3.9 1.2 0.5 1.1 0.3 1.0 7.2 0.0 0.8 0.8 0.3 4.6 0.0 0.6 0.0 3.9 0.0 0.9 0.8 0.0 0.8 8.2 0.0 0.0 0.0 1.4 8.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.9 5.1 6.0 0.0 1.0 294.8 48.8 2.0 0.0 19.7 0.0 8.9 1.1 1.0 0.0 0.1 12.7 0.3 0.1 10.6 2.2 ACVR1 "ACVR1A, ACVRLK2, ALK2, SKR1" ENSG00000115170 "Activin A receptor type 1" Q04771 2 157736444-157876330 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Microglial cells: 106.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "T-reg: 6.6" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007505, HPA046514" Approved Uncertain Nucleoli,Cytosol NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 89: Fibroblasts - ECM organization" "Cluster 30: Epithelial cell lines - Translation" "Cluster 50: Fibroblasts - ECM organization" Nucleoli Cytosol "HPA007505: AB_1844752, HPA046514: AB_2732526" "unprognostic (6.99e-2)" "unprognostic (3.32e-2)" "unprognostic (3.02e-1)" "unprognostic (1.19e-2)" "unprognostic (2.73e-1)" "unprognostic (6.09e-2)" "unprognostic (3.66e-3)" "unprognostic (1.08e-1)" "unprognostic (3.99e-1)" "unprognostic (3.20e-1)" "unprognostic (2.65e-2)" "unprognostic (4.29e-2)" "unprognostic (2.42e-1)" "unprognostic (3.43e-3)" "unprognostic (3.17e-1)" "unprognostic (1.76e-2)" "prognostic unfavorable (5.17e-4)" 20.8 10.4 17.3 12.9 12.7 1.8 18.8 14.0 15.4 28.1 17.4 16.5 10.9 24.4 32.7 11.3 17.0 24.2 19.7 26.3 12.8 26.4 22.7 17.5 8.8 13.7 12.9 21.2 10.0 8.5 10.9 17.6 13.7 15.1 12.6 6.3 18.8 15.3 21.5 13.9 10.5 34.5 12.6 8.3 14.7 5.2 16.3 7.5 40.5 13.3 8.2 20.9 15.5 11.8 6.1 13.1 14.4 18.5 65.0 70.6 18.9 43.4 71.3 33.7 36.1 10.1 13.4 0.2 18.2 45.6 32.3 16.9 10.5 22.5 36.8 43.0 8.7 25.7 7.2 14.4 54.7 2.0 28.5 89.5 41.4 69.8 84.2 42.8 38.7 6.7 9.5 6.7 45.2 11.1 0.4 0.4 21.4 8.7 21.7 4.1 19.6 5.7 45.4 24.5 12.4 14.9 17.0 9.7 64.5 22.2 5.3 7.0 54.0 50.9 16.8 25.3 17.1 4.7 3.5 0.3 52.2 1.6 58.1 2.9 1.7 0.1 0.5 1.0 0.7 0.8 4.9 1.3 1.3 0.2 1.6 0.7 0.2 1.2 1.4 1.4 6.6 1.1 17.3 12.7 14.0 15.4 26.3 12.8 13.7 12.9 13.7 12.6 16.3 11.8 9.6 9.6 9.0 22.9 1.8 9.8 7.7 12.6 12.5 10.4 8.0 9.8 12.7 11.5 12.4 7.3 0.0 8.4 1.1 4.8 5.9 9.9 1.0 5.9 12.9 17.3 4.2 1.7 34.0 17.8 5.3 20.3 8.2 6.5 5.1 4.2 18.2 13.3 7.0 3.3 34.2 4.5 24.4 13.0 8.7 2.0 20.2 7.6 3.6 106.8 5.5 6.6 2.1 42.3 22.9 17.2 4.1 15.8 6.4 13.0 3.7 15.5 13.6 2.1 13.1 16.3 19.3 0.4 2.7 4.0 7.5 10.5 4.3 3.5 4.3 8.8 ACVR1B "ActRIB, ACVRLK4, ALK4, SKR2" ENSG00000135503 "Activin A receptor type 1B" P36896 12 51951699-51997078 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 3.9" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB026126, HPA063761" Approved Approved Cytosol NA NA "Cluster 46: Basophils - DNA binding" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 39: CACO-2 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "CAB026126: , HPA063761: AB_2685115" "unprognostic (8.66e-2)" "unprognostic (5.72e-2)" "unprognostic (1.16e-1)" "unprognostic (3.23e-3)" "unprognostic (2.34e-1)" "unprognostic (2.54e-1)" "unprognostic (1.21e-3)" "unprognostic (1.00e-1)" "unprognostic (7.68e-2)" "unprognostic (5.29e-2)" "unprognostic (2.56e-1)" "unprognostic (2.37e-1)" "unprognostic (4.52e-2)" "unprognostic (9.02e-2)" "unprognostic (6.60e-2)" "unprognostic (8.96e-2)" "unprognostic (4.79e-2)" 16.5 10.3 20.7 10.0 20.8 13.5 13.2 13.6 23.4 13.9 9.1 24.6 28.2 8.8 18.0 20.9 15.3 12.2 10.1 21.5 13.3 34.3 29.9 14.7 6.4 12.5 13.9 9.4 40.7 52.7 14.7 11.1 13.1 14.0 24.4 17.4 32.8 15.3 13.1 45.6 26.1 8.1 9.5 8.8 24.9 15.7 16.1 7.6 11.4 8.8 7.4 12.6 18.8 18.3 11.4 24.3 18.6 10.3 20.9 16.2 10.5 12.6 14.2 13.1 9.9 49.5 17.1 5.0 17.2 13.8 14.6 19.6 17.8 15.2 13.5 7.3 21.0 12.3 5.9 15.6 23.8 19.9 43.8 32.0 19.4 14.8 18.6 13.9 18.7 17.7 13.3 14.9 11.8 23.2 19.1 17.2 18.0 24.0 8.5 10.2 14.4 6.4 37.2 17.0 23.5 19.5 13.6 19.2 9.0 13.1 21.1 12.8 12.0 9.0 13.6 10.2 6.1 9.0 6.8 6.7 9.7 9.4 11.8 2.5 1.2 3.9 0.3 1.8 0.5 0.0 0.3 0.3 0.7 0.2 0.8 0.4 1.0 0.0 2.2 0.3 0.5 0.3 20.7 20.8 13.6 23.4 21.5 13.3 12.5 13.9 13.1 9.5 16.1 18.3 8.0 3.2 13.4 8.1 2.9 18.6 10.1 9.2 23.3 45.3 11.3 8.6 5.9 17.2 12.0 25.8 29.2 0.7 2.0 49.7 3.9 17.7 2.9 12.3 8.1 10.9 24.6 0.8 34.8 14.4 0.8 12.6 19.9 9.0 11.4 9.4 17.9 24.4 4.0 37.0 30.2 28.7 2.0 16.7 5.3 8.4 9.9 10.0 7.2 9.4 10.1 8.8 1.0 21.6 11.3 13.3 22.1 9.4 2.3 15.1 31.8 17.0 15.8 24.5 6.6 17.5 12.2 3.8 16.5 17.7 25.3 0.5 4.6 5.6 24.7 15.5 ACVR1C "ACVRLK7, ALK7" ENSG00000123612 "Activin A receptor type 1C" Q8NER5 2 157526767-157628864 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Apoptosis "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "adipose tissue: 31.3;brain: 10.2" "Cell type enhanced" "Detected in many" "Excitatory neurons: 26.2;Leydig cells: 31.7;Oligodendrocytes: 55.8;Proximal enterocytes: 17.7" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "ASC diff: 10.9;HDLM-2: 5.1" "Low region specificity" "Detected in all" "Region enhanced" "Detected in many" "basal ganglia: 29.7" "HPA007982, HPA011933" Uncertain "Intracellular and membrane" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA007982: AB_1078134, HPA011933: AB_1844754" "unprognostic (1.03e-1)" "unprognostic (4.55e-2)" "unprognostic (9.65e-2)" "unprognostic (1.22e-1)" "unprognostic (2.92e-1)" "unprognostic (7.64e-2)" "unprognostic (1.00e-1)" "unprognostic (3.48e-1)" "unprognostic (1.01e-1)" "unprognostic (1.35e-1)" "unprognostic (7.12e-3)" "unprognostic (3.62e-1)" "unprognostic (9.31e-6)" "unprognostic (7.28e-2)" "unprognostic (1.95e-1)" "unprognostic (9.74e-2)" "unprognostic (1.30e-1)" 31.3 2.5 3.2 0.6 6.3 0.1 6.2 1.3 3.5 0.5 0.0 4.1 4.1 0.1 0.3 0.2 0.1 0.3 0.4 6.4 10.2 0.4 2.2 0.2 0.5 1.4 1.9 3.6 1.5 0.0 2.2 0.1 1.3 0.2 3.0 0.4 0.8 0.3 0.8 0.3 3.4 0.2 0.9 0.1 2.1 0.4 6.6 0.2 0.2 0.3 0.3 0.1 0.2 3.8 1.5 0.0 0.0 0.1 10.9 0.3 0.2 0.3 0.3 0.1 0.3 1.7 0.2 0.0 0.1 0.9 0.7 0.0 0.1 0.0 0.2 5.1 0.7 0.0 0.0 0.4 0.0 0.0 0.8 0.1 0.0 0.3 0.0 0.3 0.0 0.0 0.0 0.3 0.3 0.2 0.0 0.0 1.0 0.0 0.5 0.0 0.6 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.8 0.2 0.0 0.2 0.0 0.6 0.2 0.0 0.1 0.6 1.9 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.2 0.1 0.4 0.2 0.0 0.1 0.6 0.2 0.0 0.0 0.0 0.0 0.0 0.1 3.2 6.3 1.3 3.5 6.4 10.2 1.4 1.9 1.3 0.9 6.6 3.8 0.5 0.0 1.1 14.7 1.4 0.6 0.7 0.9 1.8 0.8 0.9 0.3 1.9 0.0 0.9 0.0 0.0 0.2 0.3 14.3 0.0 0.2 1.9 0.4 4.9 0.7 7.8 0.0 26.2 0.2 0.8 0.9 2.6 0.5 0.0 0.4 1.1 5.9 0.1 0.0 11.0 9.2 2.0 0.0 1.3 2.9 31.7 0.1 3.6 3.7 4.3 1.8 0.0 3.5 55.8 0.4 7.6 9.1 2.9 1.8 17.7 1.1 0.2 0.3 0.0 0.6 0.8 0.4 2.4 0.7 1.4 0.3 2.5 0.4 13.5 0.5 ACVR2A "ACTRII, ACVR2" ENSG00000121989 "Activin A receptor type 2A" P27037 2 147844517-147930826 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 62.5;Inhibitory neurons: 63.4;Oligodendrocyte precursor cells: 84.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HHSteC: 26.3;RH-30: 23.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046997 Approved Approved Cytosol NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "HPA046997: AB_10970077" "unprognostic (4.55e-2)" "unprognostic (2.26e-2)" "unprognostic (2.09e-1)" "unprognostic (7.34e-3)" "unprognostic (2.75e-1)" "unprognostic (1.17e-1)" "unprognostic (4.41e-3)" "unprognostic (8.73e-3)" "unprognostic (1.30e-2)" "unprognostic (3.61e-1)" "unprognostic (1.34e-2)" "unprognostic (1.52e-1)" "prognostic favorable (1.62e-4)" "unprognostic (1.16e-1)" "unprognostic (1.40e-1)" "unprognostic (3.95e-1)" "unprognostic (3.99e-2)" 7.3 4.0 6.2 4.6 7.4 3.3 7.0 10.8 6.4 5.4 1.0 6.3 7.7 5.2 6.6 7.2 4.5 7.7 3.7 7.5 7.5 5.6 7.4 4.6 3.1 2.6 4.5 4.5 4.4 4.3 3.9 7.7 3.9 6.8 6.5 8.3 7.5 5.2 17.5 19.5 9.3 7.0 3.8 4.0 6.8 6.4 8.6 2.3 6.7 6.3 3.9 7.4 7.4 4.6 1.8 2.1 13.2 5.0 7.3 4.7 5.4 4.1 5.0 6.9 12.0 5.8 8.1 0.1 3.6 6.7 2.5 6.2 12.0 6.1 8.8 1.4 7.3 0.9 3.6 10.2 26.3 1.0 0.9 8.1 7.3 4.5 8.9 5.2 5.3 1.6 2.0 3.5 4.7 4.8 0.4 0.8 14.9 5.5 3.6 0.2 23.3 1.3 5.6 11.5 13.0 7.3 3.5 4.2 5.4 5.6 2.5 1.4 4.1 6.4 7.5 6.1 2.9 1.0 0.3 2.4 3.9 0.5 5.2 0.2 1.7 0.2 0.6 2.0 0.2 0.1 2.4 1.1 1.3 0.3 1.5 0.3 0.0 4.8 2.0 1.7 0.2 0.7 6.2 7.4 10.8 6.4 7.5 7.5 2.6 4.5 3.9 3.8 8.6 4.6 13.7 6.4 7.0 26.8 1.5 29.7 6.9 9.5 13.1 15.4 6.8 12.4 7.9 17.2 10.7 7.3 14.6 4.9 6.0 16.5 1.9 6.3 5.3 6.4 12.2 11.9 9.0 0.0 62.5 6.3 2.5 17.4 6.6 5.7 0.0 2.2 11.7 12.1 5.4 11.8 63.4 12.9 8.2 7.3 18.9 2.1 9.9 5.7 10.6 33.7 7.2 3.3 6.2 84.9 34.1 7.6 10.0 11.3 5.2 7.7 23.7 5.8 10.2 9.4 32.9 8.3 10.9 18.2 14.1 14.4 29.8 5.3 5.9 2.9 11.7 11.8 ACVR2B ActR-IIB ENSG00000114739 "Activin A receptor type 2B" Q13705 3 38453890-38493142 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Heterotaxy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Cancer enhanced" "Detected in all" "testis cancer: 5.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 20.9;NTERA-2: 25.9;SuSa: 14.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025115, HPA040384" Approved NA No "Cluster 54: Non-specific - Microtubule organization" "Cluster 12: NES - Nervous system development" "Cluster 52: Non-specific - Transcription" "CAB025115: , HPA040384: AB_2732484" "unprognostic (5.11e-2)" "unprognostic (1.54e-1)" "unprognostic (3.47e-1)" "unprognostic (8.73e-2)" "unprognostic (9.24e-2)" "unprognostic (2.21e-1)" "unprognostic (1.32e-2)" "unprognostic (1.25e-2)" "unprognostic (1.88e-1)" "unprognostic (1.53e-2)" "unprognostic (5.14e-2)" "unprognostic (1.30e-1)" "unprognostic (4.08e-3)" "unprognostic (1.64e-1)" "unprognostic (1.98e-1)" "unprognostic (1.83e-1)" "unprognostic (4.75e-1)" 1.1 2.8 3.2 0.6 3.2 0.2 1.7 5.2 2.8 1.9 1.0 1.5 0.9 1.7 1.7 0.7 1.9 0.6 1.4 2.6 3.0 1.8 2.2 1.3 0.7 2.6 3.2 2.9 2.5 3.3 2.0 2.5 2.6 1.3 1.1 6.5 1.7 1.3 6.0 0.7 1.1 0.9 2.3 1.0 1.5 2.5 2.9 4.1 1.6 2.8 0.6 1.4 1.4 3.6 1.1 1.8 20.9 1.8 0.8 0.5 11.2 0.4 0.7 0.4 0.9 3.1 1.4 0.1 1.6 0.5 0.6 1.3 8.1 1.3 1.1 3.2 5.2 5.6 3.5 4.6 1.0 4.0 2.0 0.8 1.2 0.6 2.3 1.3 1.4 8.0 9.4 1.8 0.4 1.7 6.9 2.5 25.9 1.1 0.9 2.2 7.0 1.4 1.3 2.6 4.9 8.5 0.6 3.2 3.0 14.7 1.7 5.2 1.2 0.7 3.3 0.5 1.8 5.0 7.3 1.2 0.7 3.2 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 3.2 3.2 5.2 2.8 2.6 3.0 2.6 3.2 2.6 2.3 2.9 3.6 7.0 6.4 6.1 9.4 0.7 4.0 4.6 2.1 4.0 23.0 5.2 5.0 15.0 2.8 3.6 0.0 22.9 8.5 1.3 3.1 0.0 3.6 11.3 8.7 7.0 7.5 7.2 0.4 12.6 3.8 7.6 3.8 2.6 5.3 1.3 17.9 7.9 8.7 2.6 21.9 17.0 4.1 0.0 2.2 6.4 15.8 11.8 2.4 7.2 5.6 0.7 7.6 0.0 15.1 17.2 3.2 5.3 7.9 1.4 5.2 4.8 3.1 7.1 25.4 0.0 9.7 7.7 11.4 17.9 1.8 4.0 6.2 2.6 7.4 4.4 3.9 ACVRL1 "ACVRLK1, ALK1, HHT, HHT2, ORW2" ENSG00000139567 "Activin A receptor like type 1" P37023 12 51906908-51923361 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" Angiogenesis "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lung: 96.3" "Cell type enhanced" "Detected in many" "Adipocytes: 107.3;Distal enterocytes: 182.7;Endothelial cells: 84.7;Fibroblasts: 56.0;Hepatic stellate cells: 60.3;Paneth cells: 74.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 19 "classical monocyte: 1.5;myeloid DC: 2.1" "Group enriched" "Detected in many" 19 "dendritic cells: 2.1;monocytes: 1.5" "Cell line enhanced" "Detected in some" "ASC diff: 61.4;ASC TERT1: 42.1;EFO-21: 61.0;HUVEC TERT2: 200.0;TIME: 161.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007041 Approved "Intracellular and membrane" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA007041: AB_1078097" "unprognostic (2.50e-1)" "unprognostic (4.83e-1)" "unprognostic (3.79e-2)" "unprognostic (3.61e-2)" "unprognostic (4.98e-1)" "unprognostic (4.06e-3)" "unprognostic (2.79e-1)" "unprognostic (1.35e-1)" "unprognostic (5.80e-2)" "unprognostic (5.10e-2)" "unprognostic (4.60e-2)" "unprognostic (4.64e-2)" "unprognostic (1.12e-3)" "unprognostic (1.39e-1)" "unprognostic (7.98e-3)" "unprognostic (2.79e-1)" "unprognostic (1.10e-1)" 49.2 12.1 17.1 20.1 14.5 0.6 38.4 15.5 14.9 35.9 10.5 39.2 10.2 28.1 4.3 11.4 32.7 14.3 38.5 13.3 14.6 29.8 3.3 96.3 15.1 17.8 16.7 4.8 12.0 23.6 6.2 83.8 18.7 17.7 28.4 0.7 11.8 13.3 18.2 18.5 28.5 16.2 14.0 29.2 19.1 1.7 22.0 4.6 29.2 15.7 6.1 25.1 25.6 15.0 0.0 0.7 0.4 0.0 61.4 42.1 0.1 3.0 5.6 0.1 0.3 0.3 0.4 0.1 61.0 24.0 0.2 0.0 0.0 0.0 0.1 0.1 2.1 1.4 0.0 0.0 9.0 0.0 1.3 16.8 0.1 0.4 0.0 0.0 200.0 0.0 0.2 0.1 1.1 0.5 0.0 0.6 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.1 0.9 0.0 0.0 0.1 0.4 0.0 4.1 161.2 0.0 0.4 0.7 0.0 0.0 0.1 0.2 0.3 0.9 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 17.1 14.5 15.5 14.9 13.3 14.6 17.8 16.7 18.7 14.0 22.0 15.0 107.3 3.2 7.9 0.0 0.6 5.2 0.3 0.0 0.6 0.4 1.0 1.3 4.0 0.0 1.3 0.0 0.0 0.6 0.3 182.7 0.0 4.0 0.0 1.4 19.9 84.7 5.4 0.0 0.1 1.4 36.9 56.0 0.5 0.7 0.0 0.0 60.3 0.1 12.0 0.0 0.0 26.4 0.0 30.9 12.4 1.2 11.8 7.8 5.4 25.3 9.9 2.0 0.0 1.0 0.1 0.0 74.7 3.4 0.1 0.6 4.5 0.0 2.8 0.4 39.5 32.9 18.2 0.1 0.8 0.6 5.4 2.6 1.2 0.6 49.3 1.0 AGA ASRG ENSG00000038002 Aspartylglucosaminidase P20933 4 177430774-177442437 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "BJ hTERT+: 77.5;Karpas-707: 111.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031415, HPA031417" Enhanced "Intracellular and membrane" NA NA 36000000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 30: Epididymis - Antimicrobial activity" "Cluster 2: Karpas-707 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" "HPA031415: AB_10603578, HPA031417: AB_10670967" "unprognostic (8.76e-2)" "unprognostic (1.56e-1)" "unprognostic (2.22e-3)" "unprognostic (2.11e-3)" "unprognostic (2.70e-2)" "prognostic unfavorable (8.61e-4)" "prognostic unfavorable (1.99e-4)" "unprognostic (3.79e-1)" "unprognostic (6.44e-2)" "unprognostic (4.23e-2)" "unprognostic (4.28e-2)" "unprognostic (1.09e-1)" "unprognostic (7.49e-2)" "unprognostic (2.07e-1)" "unprognostic (3.49e-1)" "unprognostic (7.42e-2)" "unprognostic (1.47e-2)" 9.4 13.3 8.1 9.1 10.4 15.4 21.1 9.8 12.0 9.2 16.2 13.1 9.6 8.6 30.2 15.9 8.4 13.1 7.5 8.4 9.9 15.3 18.7 11.6 12.2 11.4 9.1 10.2 15.1 17.1 6.1 8.4 11.4 11.8 13.1 6.6 14.9 9.8 9.0 20.6 12.4 9.5 9.5 10.3 16.2 13.2 8.6 11.1 15.8 5.8 15.6 10.9 8.2 13.7 5.4 11.9 13.3 18.8 14.9 13.2 9.0 39.5 77.5 20.1 24.8 6.2 26.2 26.9 7.2 30.0 9.7 6.5 11.3 13.0 39.4 17.3 7.5 11.2 11.9 17.3 10.0 19.6 7.4 9.6 22.5 14.7 6.5 18.0 18.7 11.4 10.3 111.6 8.0 14.6 15.9 12.0 5.2 10.5 12.2 5.0 5.4 4.0 20.5 12.9 7.3 16.4 11.9 10.3 32.2 9.9 23.3 39.8 6.1 13.9 12.3 6.6 15.2 21.2 17.4 14.0 22.3 22.0 16.0 26.4 15.3 23.9 15.6 27.5 17.9 13.9 16.6 18.8 14.8 12.9 14.8 21.3 3.3 12.7 35.8 15.8 17.8 15.1 8.1 10.4 9.8 12.0 8.4 9.9 11.4 9.1 11.4 9.5 8.6 13.7 12.6 12.8 13.5 2.6 20.5 24.0 17.4 26.9 12.5 3.9 19.8 16.9 7.5 15.7 21.7 14.7 2.1 26.3 17.6 8.4 5.9 28.2 13.6 8.9 8.5 10.9 5.4 7.8 3.7 31.3 32.0 16.0 13.7 12.5 14.0 13.9 8.2 23.5 23.1 6.7 2.3 18.2 14.2 15.4 23.3 9.2 11.1 15.9 39.2 2.8 23.8 19.1 11.3 3.5 19.3 21.4 9.1 9.8 48.8 13.4 15.1 22.1 10.5 4.8 0.0 8.4 14.1 35.8 36.6 23.7 27.3 22.7 22.5 14.1 13.6 17.7 AKT1 "AKT, PKB, PRKBA, RAC, RAC-alpha" ENSG00000142208 "AKT serine/threonine kinase 1" P31749 14 104769349-104795751 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins, Transporters" "Apoptosis, Carbohydrate metabolism, Glucose metabolism, Glycogen biosynthesis, Glycogen metabolism, Neurogenesis, Sugar transport, Translation regulation, Transport" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "eosinophil: 61.5" "Lineage enriched" "Detected in all" 5 "granulocytes: 61.5" "Cell line enhanced" "Detected in all" "MCF7: 558.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002891, CAB003765" Supported Supported Nucleoplasm,Microtubules NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 30: Mammary glandular cells - Lactation" Nucleoplasm Microtubules "CAB003765: AB_562035, HPA002891: AB_1078123" "unprognostic (3.30e-2)" "unprognostic (4.27e-2)" "unprognostic (1.98e-1)" "unprognostic (1.84e-1)" "unprognostic (3.70e-1)" "unprognostic (9.17e-3)" "unprognostic (1.55e-3)" "unprognostic (1.21e-1)" "unprognostic (1.47e-1)" "prognostic favorable (4.83e-4)" "unprognostic (3.58e-2)" "unprognostic (1.90e-2)" "prognostic favorable (2.12e-4)" "unprognostic (7.14e-2)" "unprognostic (1.28e-1)" "unprognostic (1.06e-1)" "unprognostic (2.41e-1)" 71.5 102.7 45.9 57.7 45.5 51.2 61.2 43.7 53.2 52.0 50.4 85.0 50.8 59.5 23.2 70.7 53.7 50.0 105.9 45.2 44.3 54.3 97.3 69.2 51.9 50.5 45.7 43.7 94.3 53.0 35.9 55.4 45.0 67.2 39.6 25.1 67.7 73.0 58.1 45.0 53.3 63.4 47.4 63.7 77.8 23.9 48.0 52.4 52.3 64.9 40.3 72.6 48.4 43.3 77.3 150.5 124.6 186.9 95.2 97.7 136.9 142.3 171.5 204.6 163.6 96.8 92.8 91.2 105.5 196.6 102.8 99.4 89.5 131.9 90.1 214.3 36.2 70.6 90.4 103.2 104.6 117.5 178.0 140.0 109.1 102.9 68.1 98.2 154.4 87.5 62.1 102.2 134.1 558.3 145.3 146.8 32.6 153.5 107.2 137.5 111.9 60.5 94.8 189.5 141.2 117.2 117.3 152.2 88.9 56.8 195.7 170.2 123.5 133.2 63.2 192.3 145.1 105.4 52.6 80.7 113.7 96.7 162.0 6.4 9.9 61.5 10.0 10.3 7.2 5.5 8.7 11.4 7.0 7.2 4.6 10.1 22.6 11.0 12.4 10.0 9.0 6.3 45.9 45.5 43.7 53.2 45.2 44.3 50.5 45.7 45.0 47.4 48.0 43.3 45.8 16.0 27.4 16.6 13.7 12.4 20.0 17.3 15.9 26.3 58.0 39.9 16.1 32.9 17.7 22.0 12.5 19.4 54.2 40.9 13.7 23.6 1.9 17.9 28.1 27.5 30.0 11.3 8.2 35.2 31.8 24.0 26.0 24.8 2.5 40.4 23.2 42.9 23.2 42.1 13.0 37.3 22.4 23.3 21.4 3.3 28.6 28.0 10.6 6.5 23.1 51.2 24.7 8.0 9.6 53.3 22.1 30.9 10.3 38.8 23.5 17.9 14.2 26.6 26.3 24.9 29.1 1.8 5.3 16.2 13.9 23.4 23.3 34.0 33.7 33.4 AKT2 PKBβ ENSG00000105221 "AKT serine/threonine kinase 2" P31751 19 40230317-40285536 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Carbohydrate metabolism, Glucose metabolism, Glycogen biosynthesis, Glycogen metabolism, Sugar transport, Translation regulation, Transport" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Diabetes mellitus, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004204, HPA064521" Uncertain Supported Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 17: Basophils - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Vesicles, Cytosol" "CAB004204: AB_626659, HPA064521: AB_2685278" "unprognostic (6.13e-2)" "unprognostic (2.21e-1)" "unprognostic (1.56e-1)" "prognostic unfavorable (1.05e-6)" "unprognostic (2.85e-1)" "unprognostic (6.40e-3)" "unprognostic (9.59e-2)" "unprognostic (1.22e-2)" "unprognostic (2.98e-2)" "unprognostic (2.49e-2)" "unprognostic (3.02e-1)" "prognostic unfavorable (4.74e-4)" "unprognostic (1.30e-2)" "unprognostic (1.89e-1)" "unprognostic (3.28e-1)" "unprognostic (6.16e-2)" "unprognostic (2.00e-1)" 62.8 40.0 31.7 37.3 31.3 48.4 38.6 58.3 40.0 49.8 55.1 42.3 24.5 43.5 49.4 42.5 46.1 25.1 40.8 31.5 24.5 52.2 59.2 30.7 38.1 32.0 26.0 53.9 41.9 58.5 47.8 27.6 26.3 41.2 23.3 41.2 32.5 45.0 101.3 39.4 35.6 34.2 22.1 38.1 33.1 29.7 28.0 53.4 100.1 118.7 37.0 39.8 41.5 35.2 66.2 160.1 63.1 61.5 72.0 88.9 32.5 41.7 63.5 87.6 77.9 71.8 60.8 67.4 36.8 96.3 37.2 28.2 66.8 90.0 56.1 62.5 74.3 43.4 116.5 44.7 45.8 50.7 50.5 82.7 53.6 58.6 56.4 71.9 19.0 73.0 57.3 67.5 49.8 54.6 81.1 24.7 31.7 73.7 41.5 54.2 32.1 48.5 68.3 105.7 82.7 49.8 43.3 75.0 35.0 62.5 59.8 64.9 18.8 52.7 51.5 47.3 67.6 61.5 59.0 56.4 52.6 59.7 44.3 5.7 2.6 2.1 2.2 1.2 2.2 1.9 1.8 1.5 1.7 2.9 1.7 2.6 4.0 1.7 1.6 4.9 1.6 1.7 31.7 31.3 58.3 40.0 31.5 24.5 32.0 26.0 26.3 22.1 28.0 35.2 18.1 16.0 15.9 51.2 33.0 23.8 23.9 20.9 26.2 67.6 25.3 23.9 31.2 30.0 18.1 60.7 41.7 31.3 26.0 23.7 21.5 19.7 5.5 26.2 26.7 17.4 19.2 19.1 30.4 30.4 25.2 27.9 20.9 25.8 14.0 44.2 13.9 87.5 22.3 60.6 25.3 20.1 22.4 23.2 17.5 10.5 42.9 20.0 23.2 23.4 21.7 46.2 50.4 41.7 40.6 24.8 16.9 26.7 30.4 29.7 21.8 24.8 24.9 97.4 19.7 29.3 25.0 14.8 15.6 31.1 27.4 38.7 23.1 56.9 23.3 29.4 AKT3 "PKBG, PRKBG, RAC-gamma" ENSG00000117020 "AKT serine/threonine kinase 3" Q9Y243 1 243488233-243851079 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 59.9" "Group enriched" "Detected in many" 6 "Astrocytes: 457.4;Excitatory neurons: 756.1;Inhibitory neurons: 514.5;Microglial cells: 414.1;Oligodendrocyte precursor cells: 633.3;Oligodendrocytes: 475.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013090, HPA026441" Approved Supported Cytosol NA NA "Cluster 11: Basophils - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "CAB013090: AB_2533692, HPA026441: AB_1844711" "unprognostic (1.33e-1)" "unprognostic (1.27e-1)" "unprognostic (2.40e-2)" "unprognostic (8.45e-2)" "unprognostic (1.89e-1)" "unprognostic (1.75e-1)" "unprognostic (1.96e-1)" "unprognostic (3.77e-1)" "unprognostic (2.32e-1)" "unprognostic (2.28e-1)" "unprognostic (5.47e-3)" "unprognostic (1.37e-1)" "unprognostic (6.71e-2)" "unprognostic (3.64e-3)" "unprognostic (1.29e-1)" "unprognostic (8.14e-2)" "prognostic unfavorable (9.27e-4)" 19.3 9.7 13.4 6.0 17.0 3.8 15.5 59.9 36.6 20.0 0.0 24.5 2.6 22.7 8.6 5.9 20.3 8.2 11.8 22.8 5.6 11.2 4.7 15.3 5.9 1.2 3.9 26.4 4.5 7.4 13.9 13.1 7.4 15.8 4.9 17.0 5.1 15.6 5.9 6.3 11.8 15.7 0.8 8.1 10.2 9.7 20.3 7.0 14.4 11.5 4.6 18.8 14.8 31.1 30.8 7.2 31.0 0.4 16.9 20.6 13.9 20.8 22.5 11.8 12.9 1.1 13.9 0.5 3.0 28.9 12.1 1.2 16.3 8.5 18.9 9.0 15.3 1.0 1.0 0.3 11.7 0.6 6.5 11.3 0.3 15.5 16.9 30.3 30.2 7.2 0.5 1.1 9.0 0.9 7.6 3.3 14.4 0.3 5.1 4.2 19.7 0.6 4.8 4.1 31.4 41.9 1.3 0.5 40.1 19.1 1.9 21.5 25.6 22.7 17.7 1.1 19.5 4.6 4.6 7.1 19.4 5.2 25.3 1.3 0.8 0.1 0.6 0.1 1.1 0.6 0.6 0.6 0.3 0.8 0.6 0.7 0.7 1.4 0.3 0.5 0.1 0.3 13.4 17.0 59.9 36.6 22.8 5.6 1.2 3.9 7.4 0.8 20.3 31.1 65.4 3.2 2.2 457.4 22.2 2.4 15.0 1.3 17.1 43.6 6.1 5.1 5.4 4.3 2.7 27.6 33.3 11.0 24.4 0.0 0.0 11.6 82.8 1.7 35.5 43.7 0.0 5.0 756.1 1.7 8.0 27.9 2.6 1.1 5.1 29.7 48.2 0.6 2.9 42.1 514.5 0.0 2.0 10.5 12.5 72.8 27.4 9.5 7.2 414.1 8.6 20.1 19.6 633.3 475.9 0.7 0.0 35.3 14.4 27.0 0.0 6.9 0.3 35.0 19.7 40.1 35.6 15.0 14.6 1.7 1.7 12.4 27.8 8.3 0.0 12.2 ALDH18A1 "GSAS, P5CS, PYCS, SPG9" ENSG00000059573 "Aldehyde dehydrogenase 18 family member A1" P54886 10 95605941-95656711 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Amino-acid biosynthesis, Proline biosynthesis" "Kinase, Multifunctional enzyme, Oxidoreductase, Transferase" "Disease variant, Hereditary spastic paraplegia, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "salivary gland: 120.1" "Cell type enhanced" "Detected in many" "Distal enterocytes: 80.5;Granulosa cells: 81.6;Proximal enterocytes: 79.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008333, HPA012604" Approved Enhanced Mitochondria NA NA 48000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 40: Granulosa cells - Unknown function" Mitochondria "HPA008333: AB_1078125, HPA012604: AB_1844721" "unprognostic (5.97e-3)" "unprognostic (2.08e-2)" "unprognostic (5.75e-2)" "prognostic favorable (4.20e-4)" "unprognostic (1.60e-2)" "unprognostic (1.06e-1)" "unprognostic (8.30e-3)" "unprognostic (7.08e-2)" "unprognostic (4.06e-2)" "unprognostic (8.04e-2)" "unprognostic (1.30e-1)" "unprognostic (1.81e-1)" "prognostic unfavorable (3.60e-9)" "unprognostic (1.02e-3)" "unprognostic (6.57e-2)" "unprognostic (1.29e-3)" "unprognostic (6.43e-2)" 15.3 16.1 12.2 21.2 12.6 16.7 20.2 12.4 13.1 33.4 21.0 51.9 89.3 18.5 30.9 21.0 21.9 25.2 11.5 12.2 13.6 17.7 24.3 10.8 22.0 12.4 14.7 16.7 61.8 33.5 28.2 26.3 13.1 24.2 49.3 11.4 120.1 24.9 4.3 22.4 73.1 26.3 12.7 12.1 40.5 11.7 14.0 17.2 37.5 5.5 26.9 25.2 14.3 13.1 66.5 61.6 57.9 152.7 76.0 72.9 62.2 75.6 112.8 75.1 93.7 124.4 51.6 223.7 68.9 119.7 36.2 85.6 117.1 77.8 84.6 64.0 92.0 71.2 40.5 177.9 49.7 125.6 76.1 77.0 46.8 61.5 119.1 124.5 79.9 82.6 67.5 46.0 57.1 95.0 114.5 80.5 68.6 109.2 60.7 105.9 66.3 76.9 88.3 49.7 57.5 56.9 60.1 47.1 56.9 66.0 70.5 57.9 66.7 31.1 49.0 80.9 88.2 52.4 41.7 135.8 60.4 142.8 40.7 0.1 2.6 0.2 27.3 5.2 28.7 23.0 24.5 28.3 9.6 16.1 20.7 23.1 0.5 26.3 8.3 5.9 25.8 15.5 12.2 12.6 12.4 13.1 12.2 13.6 12.4 14.7 13.1 12.7 14.0 13.1 4.6 6.4 9.2 7.2 12.6 11.2 8.3 8.9 14.2 6.3 15.6 12.4 4.6 11.5 14.3 20.2 0.0 43.9 6.7 80.5 1.9 13.7 1.3 12.7 18.1 8.0 19.8 17.9 15.7 21.1 31.6 16.2 18.8 16.9 8.2 81.6 5.3 27.3 11.5 10.1 13.6 41.3 8.2 3.5 3.8 1.6 9.3 3.5 16.0 11.2 2.6 7.1 8.2 17.6 12.8 11.7 56.4 12.0 30.1 18.4 79.4 8.4 15.2 3.4 0.0 10.5 10.1 8.2 9.9 17.6 8.1 30.2 9.0 10.8 38.7 9.4 ALDH1B1 "ALDH5, ALDHX" ENSG00000137124 "Aldehyde dehydrogenase 1 family member B1" P30837 9 38392702-38398661 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 172.7;smooth muscle: 128.0" "Cell type enhanced" "Detected in many" "Cholangiocytes: 85.8;Ductal cells: 64.1;Hepatocytes: 128.1;Proximal tubular cells: 165.0;Theca cells: 91.7;Undifferentiated cells: 71.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "OE19: 183.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA021037, HPA077080" Enhanced Supported Nucleoplasm,Mitochondria,Cytosol NA NA 500000 "Cluster 27: Non-specific - Gene expression" "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "Nucleoplasm, Cytosol" "HPA021037: AB_1844724, HPA077080: " "unprognostic (4.16e-1)" "unprognostic (1.98e-2)" "unprognostic (5.84e-2)" "unprognostic (1.55e-3)" "unprognostic (2.47e-2)" "unprognostic (4.48e-3)" "unprognostic (2.84e-3)" "unprognostic (2.70e-2)" "unprognostic (1.91e-1)" "unprognostic (1.35e-1)" "unprognostic (2.09e-1)" "unprognostic (1.00e-1)" "prognostic favorable (2.05e-4)" "unprognostic (1.04e-1)" "unprognostic (1.63e-1)" "prognostic unfavorable (1.17e-5)" "unprognostic (2.89e-2)" 21.2 10.4 3.2 31.4 3.2 2.9 8.9 4.1 4.0 8.5 6.4 61.5 22.9 57.7 5.7 32.7 34.9 29.0 14.7 2.7 4.8 59.2 172.7 7.3 5.1 3.5 3.3 12.6 11.3 8.5 2.5 5.2 4.3 36.9 35.5 1.5 11.1 54.5 55.8 6.3 24.8 128.0 3.4 7.2 28.2 8.3 4.0 5.1 15.4 35.9 5.6 85.1 10.5 4.1 72.2 65.5 19.8 31.8 27.6 32.5 15.8 33.6 16.9 27.8 28.3 44.2 13.7 45.2 19.7 47.4 42.0 10.0 66.0 71.4 27.4 50.8 28.5 22.4 44.7 132.2 20.0 36.0 24.0 39.0 15.3 22.6 19.5 56.6 26.8 10.6 65.6 42.8 42.8 27.3 0.1 14.4 59.1 183.3 29.0 14.9 119.9 34.5 25.1 31.7 43.3 19.9 25.7 16.7 19.4 20.6 15.9 27.9 18.2 31.9 52.4 26.9 42.5 6.5 13.2 17.8 16.4 36.0 22.1 0.3 4.2 0.2 6.7 9.2 9.6 5.5 6.5 6.1 9.5 2.6 5.1 6.2 1.0 8.0 11.9 1.2 5.0 5.3 3.2 3.2 4.1 4.0 2.7 4.8 3.5 3.3 4.3 3.4 4.0 4.1 3.3 9.6 1.7 0.0 3.7 1.0 5.7 9.4 2.2 1.2 3.7 4.2 6.6 85.8 3.8 16.5 2.1 2.0 1.2 12.8 17.6 64.1 0.6 2.3 6.4 4.7 15.6 12.8 0.5 6.9 46.6 6.6 8.2 3.4 8.9 12.8 8.9 128.1 7.2 0.0 1.1 25.5 6.1 4.1 2.4 2.2 6.5 4.2 0.0 0.0 5.5 2.1 0.0 0.5 0.5 15.0 7.7 6.8 3.7 6.1 10.3 165.0 0.3 0.7 0.0 6.0 16.1 0.6 0.8 2.1 1.0 1.8 3.3 91.7 71.7 2.8 ALDH2 ENSG00000111275 "Aldehyde dehydrogenase 2 family member" P05091 12 111766887-111817532 "Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Oxidoreductase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 857.7" "Cell type enhanced" "Detected in all" "Hepatocytes: 857.0;monocytes: 940.8;Proximal tubular cells: 882.0" "Cancer enhanced" "Detected in all" "liver cancer: 71.5" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "classical monocyte: 212.0;myeloid DC: 213.2" "Group enriched" "Detected in many" 4 "dendritic cells: 213.2;monocytes: 212.0" "Cell line enhanced" "Detected in many" "ASC diff: 86.8;HHSteC: 97.0;OE19: 152.2;SK-BR-3: 201.0;THP-1: 92.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA051065 Approved NA NA 2200000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 15: Liver - Metabolism" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA051065: AB_2681332" "unprognostic (9.22e-3)" "unprognostic (1.20e-2)" "unprognostic (4.14e-3)" "prognostic favorable (2.63e-4)" "unprognostic (1.16e-1)" "unprognostic (1.32e-3)" "prognostic favorable (3.95e-7)" "unprognostic (5.62e-3)" "unprognostic (3.00e-1)" "unprognostic (1.16e-1)" "unprognostic (8.22e-2)" "unprognostic (1.51e-1)" "prognostic favorable (5.24e-6)" "unprognostic (9.70e-2)" "unprognostic (3.40e-1)" "unprognostic (1.50e-2)" "prognostic unfavorable (7.71e-4)" 303.8 102.4 139.7 39.8 146.1 29.2 77.2 136.5 163.5 25.0 123.3 73.3 73.7 30.1 21.3 73.6 32.3 37.4 111.3 132.2 139.7 177.7 857.7 111.6 18.7 140.7 144.9 42.0 23.3 2.6 23.3 7.0 141.1 34.6 72.3 29.2 32.4 29.5 130.8 127.9 74.8 30.2 143.0 20.6 101.5 13.0 151.8 27.1 30.8 165.7 52.9 50.0 29.0 144.5 8.8 13.1 18.7 31.9 86.8 13.0 60.9 9.3 16.8 4.3 3.1 23.5 12.1 0.5 45.3 20.8 11.9 16.2 0.1 4.6 2.7 0.6 6.1 0.7 8.4 64.7 97.0 0.9 0.9 23.9 22.6 14.8 0.3 17.7 26.9 0.9 17.9 3.0 4.1 0.5 1.0 23.4 24.8 152.2 2.1 0.6 0.4 1.9 31.4 0.6 7.5 23.1 22.8 201.0 0.2 33.7 20.3 92.1 1.1 0.4 16.5 0.6 0.4 5.5 3.0 25.7 22.0 0.8 0.4 6.5 212.0 51.1 0.7 93.0 0.9 6.2 0.3 0.7 213.2 5.2 0.7 0.5 10.7 3.4 25.4 70.6 0.5 123.5 139.7 146.1 136.5 163.5 132.2 139.7 140.7 144.9 141.1 143.0 151.8 144.5 27.7 147.4 242.7 51.2 22.6 60.0 205.2 311.1 80.8 78.7 35.0 23.7 378.9 165.8 243.1 66.2 18.8 62.4 48.6 260.3 399.2 127.5 4.3 27.8 24.5 66.2 55.2 42.1 11.7 218.0 127.5 103.1 200.3 47.7 30.9 29.0 139.6 857.0 129.2 35.3 18.2 231.0 101.7 278.5 124.1 10.6 79.9 189.3 35.6 26.2 940.8 130.2 8.2 14.1 6.8 130.2 366.5 149.0 12.5 84.4 384.3 882.0 89.4 42.6 46.0 46.0 67.6 3.0 3.9 105.1 124.7 42.1 13.1 81.0 272.6 150.4 ALDH3A2 "ALDH10, FALDH, SLS" ENSG00000072210 "Aldehyde dehydrogenase 3 family member A2" P51648 17 19648136-19685760 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Fatty acid metabolism, Lipid metabolism" Oxidoreductase "Disease variant, Ichthyosis, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 288.6" "Cell type enhanced" "Detected in all" "Basal squamous epithelial cells: 287.4;Squamous epithelial cells: 232.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "OE19: 285.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014769, CAB020692" Enhanced Approved "Endoplasmic reticulum,Cytosol" NA NA 32000 "Cluster 14: Monocytes - Unknown function" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 61: Squamous epithelial cells - Keratinization" "Endoplasmic reticulum, Cytosol" "CAB020692: , HPA014769: AB_1844728" "unprognostic (1.42e-1)" "unprognostic (7.62e-2)" "unprognostic (7.77e-2)" "unprognostic (2.49e-2)" "unprognostic (4.59e-1)" "unprognostic (1.64e-1)" "unprognostic (1.59e-1)" "unprognostic (1.31e-2)" "unprognostic (2.23e-1)" "unprognostic (3.93e-3)" "unprognostic (2.40e-1)" "unprognostic (2.63e-1)" "prognostic favorable (3.85e-8)" "unprognostic (4.12e-2)" "unprognostic (1.55e-1)" "unprognostic (1.42e-2)" "unprognostic (1.26e-1)" 75.2 203.0 23.1 15.2 32.5 9.3 34.9 24.8 27.7 49.4 71.7 49.6 68.1 29.4 41.7 131.3 38.3 70.5 44.6 29.0 27.9 173.0 288.6 59.1 14.9 23.3 26.3 32.3 52.3 40.6 21.9 11.8 23.5 75.0 36.5 40.8 61.7 41.5 53.0 207.6 71.8 30.2 25.1 19.4 81.5 26.9 24.8 23.0 75.1 100.9 36.4 24.2 40.5 33.6 27.7 147.0 29.2 58.5 88.7 89.4 19.1 12.3 29.9 24.4 27.6 63.2 52.5 12.3 35.9 50.5 29.3 99.0 59.8 125.2 19.9 36.2 42.5 5.3 120.9 142.8 12.2 30.6 5.4 42.9 137.6 22.9 12.2 49.7 49.2 25.5 2.2 0.6 37.3 45.3 0.7 25.2 32.3 285.4 78.5 38.6 64.1 25.3 17.5 132.3 46.3 30.4 98.9 38.4 35.3 152.2 78.1 35.0 46.7 10.1 28.7 68.8 45.6 11.3 28.6 15.5 47.4 0.3 48.3 0.8 21.1 17.5 6.3 18.3 9.9 5.2 6.0 6.1 20.7 4.9 6.8 6.3 2.2 15.0 20.6 1.3 11.3 11.0 23.1 32.5 24.8 27.7 29.0 27.9 23.3 26.3 23.5 25.1 24.8 33.6 22.1 176.3 86.5 14.7 13.3 57.1 143.9 85.1 287.4 15.3 13.6 24.0 54.1 105.8 86.5 33.1 12.5 12.5 8.2 48.9 43.0 97.5 79.6 47.5 13.4 19.5 16.2 8.2 30.5 52.0 4.6 39.9 87.7 36.9 29.7 34.6 13.6 116.7 24.6 6.7 20.1 27.7 26.4 21.7 15.1 19.5 55.9 23.5 7.2 13.1 25.7 105.9 8.2 19.6 29.1 43.9 28.7 80.5 28.6 104.2 90.6 119.2 59.2 21.4 13.1 70.1 22.1 15.5 24.0 232.6 90.2 1.4 13.2 29.1 46.0 51.4 ALDH7A1 "ATQ1, EPD, PDE" ENSG00000164904 "Aldehyde dehydrogenase 7 family member A1" P49419 5 126531200-126595362 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 162.2" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 414.1;Proximal tubular cells: 302.1;Syncytiotrophoblasts: 222.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "plasmacytoid DC: 6.4" "Lineage enriched" "Detected in many" 5 "dendritic cells: 6.4" "Cell line enhanced" "Detected in many" "HBEC3-KT: 256.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023296, HPA053675" Enhanced Supported Mitochondria,Cytosol Yes No 430000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 15: Liver - Metabolism" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Mitochondria Cytosol "HPA023296: AB_1844738, HPA053675: " "unprognostic (1.37e-1)" "unprognostic (9.67e-2)" "unprognostic (2.07e-2)" "unprognostic (2.20e-2)" "unprognostic (4.15e-2)" "unprognostic (1.32e-1)" "unprognostic (1.58e-3)" "unprognostic (9.49e-3)" "unprognostic (7.61e-2)" "unprognostic (7.08e-2)" "unprognostic (2.10e-1)" "unprognostic (1.33e-1)" "prognostic favorable (3.08e-4)" "unprognostic (1.51e-1)" "unprognostic (3.70e-1)" "unprognostic (3.10e-3)" "unprognostic (4.93e-2)" 23.7 38.3 46.6 9.1 47.6 1.8 47.1 43.7 45.8 32.7 40.7 29.5 23.7 25.1 8.8 35.9 28.8 19.1 27.9 44.7 43.2 115.1 162.2 15.7 8.6 43.1 43.5 65.3 27.0 34.0 8.8 44.9 42.6 42.0 27.4 19.7 40.6 27.9 12.2 29.4 21.0 23.6 44.8 7.0 23.6 12.3 44.0 18.3 47.6 26.5 17.1 18.1 20.9 45.2 64.9 41.9 116.6 193.4 95.5 56.4 147.8 76.1 93.4 86.5 110.5 118.6 60.7 0.0 75.5 60.0 36.1 47.1 36.5 256.2 78.8 0.1 44.6 12.3 63.1 102.1 46.3 0.2 0.0 69.0 59.2 67.3 47.7 64.2 70.0 0.0 0.0 0.1 77.1 42.1 2.6 0.3 79.4 47.5 35.2 38.9 131.8 0.0 81.2 48.4 39.4 47.2 0.0 41.1 44.7 89.0 75.2 2.7 86.1 24.8 75.6 28.8 53.1 0.1 0.1 0.4 13.4 0.2 40.6 0.7 0.2 0.1 0.1 0.0 0.2 0.8 0.2 0.1 1.8 0.6 1.2 0.6 0.1 0.1 0.0 6.4 0.0 0.4 46.6 47.6 43.7 45.8 44.7 43.2 43.1 43.5 42.6 44.8 44.0 45.2 17.6 16.0 29.3 99.3 5.0 25.9 59.5 110.0 87.0 23.6 40.6 91.1 39.9 27.1 43.5 42.3 22.9 414.1 3.7 15.2 76.3 43.5 31.4 18.7 44.3 19.1 21.7 5.2 16.0 13.8 107.8 34.0 27.0 21.4 7.0 50.4 18.9 74.6 51.1 25.2 21.5 25.9 20.3 9.4 7.6 41.7 25.4 9.1 55.2 12.2 7.5 102.1 0.0 41.7 30.0 12.6 15.6 37.2 2.0 27.5 23.4 302.1 23.4 13.6 19.7 19.4 25.8 1.0 5.1 59.2 16.1 222.3 4.6 39.3 46.4 50.4 ALDH9A1 "ALDH4, ALDH7, ALDH9, E3" ENSG00000143149 "Aldehyde dehydrogenase 9 family member A1" P49189 1 165662216-165698863 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Muller glia cells: 311.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "HPA006077, HPA010873" Approved Approved Cytosol "Intracellular and membrane" NA NA 2000000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 43: THP-1 - Innate immune response" "Cluster 39: Non-specific - Basic cellular processes" Cytosol "HPA006077: , HPA010873: AB_1078126" "unprognostic (2.24e-1)" "unprognostic (3.16e-2)" "unprognostic (4.17e-2)" "unprognostic (1.25e-1)" "unprognostic (3.21e-2)" "unprognostic (1.25e-1)" "unprognostic (4.14e-2)" "unprognostic (4.87e-2)" "unprognostic (2.30e-1)" "unprognostic (1.83e-1)" "prognostic favorable (4.56e-4)" "unprognostic (5.51e-2)" "unprognostic (9.05e-2)" "unprognostic (1.67e-1)" "unprognostic (1.49e-1)" "unprognostic (1.43e-1)" "unprognostic (2.15e-1)" 119.2 105.5 49.6 29.8 51.0 24.8 76.8 49.3 60.3 51.5 62.5 45.7 54.8 38.6 93.4 105.6 50.2 32.0 48.2 47.4 57.5 142.4 206.5 38.5 40.3 50.5 52.1 53.6 44.0 81.9 39.9 38.0 51.4 65.3 50.6 46.4 104.1 45.6 93.6 54.7 48.6 42.0 50.7 37.9 39.5 63.4 49.3 39.0 123.0 56.4 60.1 39.4 43.9 55.6 55.7 53.5 48.7 44.1 152.1 132.8 40.7 71.9 101.5 70.8 61.0 33.4 40.7 0.1 67.1 64.8 34.9 42.8 40.0 70.3 83.0 25.9 50.6 35.3 34.7 36.5 78.2 56.0 36.1 86.0 34.8 75.2 62.5 97.8 62.2 45.9 56.9 48.4 111.7 33.4 37.6 57.6 71.3 145.1 64.7 31.7 62.0 74.3 92.5 52.0 57.7 39.8 51.4 57.1 67.4 65.6 108.8 84.0 61.9 42.5 41.5 52.4 37.1 44.7 62.5 54.8 47.9 52.6 41.7 61.8 35.2 50.9 45.5 37.7 48.8 49.9 43.8 49.6 34.5 46.8 43.8 50.4 51.3 43.0 45.3 21.6 69.8 45.6 49.6 51.0 49.3 60.3 47.4 57.5 50.5 52.1 51.4 50.7 49.3 55.6 56.2 16.0 47.6 12.7 43.3 32.6 43.3 43.8 68.3 25.0 83.0 54.6 46.5 55.8 36.8 51.5 22.9 48.5 39.3 43.9 97.8 42.9 45.4 27.7 39.1 49.4 55.8 28.2 5.6 37.0 76.4 60.6 36.2 20.4 38.0 60.9 59.3 158.8 61.9 13.5 8.3 56.9 32.6 59.1 24.9 39.8 95.4 43.8 56.9 6.5 34.6 311.5 39.1 12.1 12.2 32.2 33.1 115.5 34.8 39.6 80.3 204.4 59.4 28.9 26.3 32.5 40.1 85.6 49.9 123.8 51.9 38.2 43.7 148.4 63.6 28.3 AMFR "gp78, RNF45" ENSG00000159461 "Autocrine motility factor receptor" Q9UKV5 16 56361452-56425545 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway, Wnt signaling pathway" "Receptor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 154.5;Hepatocytes: 166.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB026381, HPA029018, HPA077835" Approved Supported "Endoplasmic reticulum,Golgi apparatus" NA NA "Cluster 42: Non-specific - Transcription" "Cluster 54: Non-specific - Microtubule organization" "Cluster 6: T47d - Mammary gland" "Cluster 2: Hepatocytes - Metabolism" "Endoplasmic reticulum, Golgi apparatus" "CAB026381: , HPA029018: AB_2672869, HPA077835: AB_2686856" "unprognostic (1.72e-2)" "unprognostic (1.62e-1)" "unprognostic (1.62e-2)" "unprognostic (2.43e-2)" "unprognostic (3.60e-3)" "unprognostic (6.06e-2)" "unprognostic (1.04e-1)" "unprognostic (1.26e-3)" "unprognostic (1.28e-1)" "unprognostic (1.43e-1)" "unprognostic (2.97e-1)" "unprognostic (4.16e-2)" "unprognostic (5.52e-3)" "unprognostic (1.45e-1)" "unprognostic (1.68e-1)" "unprognostic (1.91e-1)" "unprognostic (2.28e-1)" 29.6 53.1 49.7 22.8 58.0 36.9 27.5 56.6 48.0 34.4 78.5 29.1 47.5 33.6 51.5 44.2 31.7 29.2 32.1 50.2 56.7 64.8 75.4 27.1 40.2 62.1 58.4 40.1 29.2 70.6 24.2 41.0 62.6 28.0 25.0 57.6 25.6 37.4 159.4 24.9 36.0 33.9 65.3 26.9 24.6 83.7 57.2 20.6 33.8 56.5 43.5 25.8 29.4 75.7 55.5 75.2 32.4 59.2 98.2 54.7 28.4 56.8 71.2 77.0 60.1 66.4 49.4 142.0 65.3 79.1 45.2 50.3 49.9 45.1 72.9 31.7 51.2 40.9 29.2 73.4 85.7 33.2 45.6 64.1 64.3 61.7 73.1 53.6 45.6 41.0 45.7 18.8 56.9 33.7 50.7 35.8 15.3 28.2 51.1 57.0 64.8 53.6 47.9 57.0 32.2 24.6 135.6 47.3 45.5 30.3 142.3 35.0 59.4 72.3 39.4 36.9 39.7 40.7 38.5 75.8 52.7 23.4 33.7 37.1 10.0 14.4 7.9 12.5 11.2 21.7 9.9 8.3 9.9 17.9 10.1 10.9 12.5 14.2 17.9 13.2 11.4 5.5 49.7 58.0 56.6 48.0 50.2 56.7 62.1 58.4 62.6 65.3 57.2 75.7 25.7 9.6 9.0 23.8 34.0 25.7 18.1 11.0 10.8 17.7 58.9 23.0 19.9 28.6 11.7 99.3 39.6 27.5 17.4 53.6 25.4 20.8 154.5 16.4 26.4 23.5 24.7 29.0 20.5 43.0 6.8 31.9 8.6 32.4 8.8 31.8 38.9 166.4 17.0 32.0 23.7 23.6 12.2 69.1 33.2 118.7 41.0 25.5 30.2 23.4 25.5 50.1 10.3 27.6 31.5 35.6 25.3 34.3 12.0 36.0 53.4 54.3 9.2 43.3 13.1 29.4 24.1 30.5 11.7 12.0 20.9 24.4 17.1 34.1 22.9 29.7 AMHR2 "MISR2, MISRII" ENSG00000135409 "Anti-Mullerian hormone receptor type 2" Q16671 12 53423855-53431672 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Disease variant, Pseudohermaphroditism" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "adrenal gland: 41.5;ovary: 33.1" "Group enriched" "Detected in some" 4 "granulocytes: 26.0;Granulosa cells: 36.1;Theca cells: 94.9" "Cancer enhanced" "Detected in single" "testis cancer: 0.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 19 "HEL: 40.1;K-562: 22.2" "Low region specificity" "Detected in many" "Region enriched" "Detected in single" 11 "hippocampal formation: 9.4" "HPA060228, HPA069636" Approved Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 51: Non-specific - Unknown function" "Cluster 36: HEL - Hemostasis" "Cluster 52: Non-specific - Transcription" Vesicles "Nucleoplasm, Cytosol" "HPA060228: AB_2684227, HPA069636: AB_2686163" "unprognostic (5.79e-2)" "unprognostic (3.65e-1)" "unprognostic (3.98e-1)" "unprognostic (1.71e-1)" "unprognostic (1.14e-1)" "unprognostic (4.61e-3)" "unprognostic (2.33e-1)" "unprognostic (1.44e-2)" "unprognostic (2.91e-1)" "unprognostic (4.98e-2)" "unprognostic (1.35e-1)" "unprognostic (2.32e-1)" "unprognostic (2.15e-2)" "unprognostic (3.34e-2)" "unprognostic (1.42e-1)" "unprognostic (2.04e-1)" "unprognostic (1.97e-1)" 0.6 41.5 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.2 0.0 0.1 0.1 0.1 0.0 0.3 0.4 0.1 0.5 0.0 0.3 0.0 0.9 0.4 0.0 0.0 0.2 33.1 12.5 0.4 0.1 0.0 0.0 0.1 0.1 0.0 0.1 0.0 4.2 0.1 0.1 0.0 0.0 5.7 0.7 9.1 0.5 0.0 0.0 1.8 0.0 0.2 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 1.6 40.1 0.0 0.8 0.0 0.0 1.3 0.1 0.0 0.0 0.0 0.1 0.0 0.0 22.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.9 3.5 2.6 0.0 0.1 1.5 0.0 4.2 0.1 2.1 0.1 2.7 0.0 0.1 26.0 36.1 11.4 0.3 0.1 0.0 0.0 0.0 0.0 1.2 0.0 2.5 5.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 4.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.3 1.1 0.3 0.0 0.0 0.3 0.8 94.9 0.1 0.0 ANKRD1 "ALRP, C-193, CARP, CVARP, MCARP" ENSG00000148677 "Ankyrin repeat domain 1" Q15327 10 90912096-90921087 "Metabolic proteins, Predicted intracellular proteins" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 11 "heart muscle: 6540.8" "Cell type enriched" "Detected in some" 15 "Cardiomyocytes: 13820.4" "Cancer enhanced" "Detected in many" "head and neck cancer: 7.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CACO-2: 474.5;EFO-21: 1248.9;hTERT-RPE1: 679.8;LHCN-M2: 1573.6;SuSa: 469.1;TIME: 2206.7" "Not detected" "Not detected" "Not detected" "Not detected" HPA038736 Enhanced Approved "Nucleoplasm,Nucleoli fibrillar center" NA Yes "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 54: Cardiomyocytes - Muscle contraction" "Nucleoli fibrillar center" Nucleoplasm "HPA038736: AB_2676184" "unprognostic (2.45e-1)" "unprognostic (6.14e-3)" "unprognostic (2.24e-1)" "unprognostic (4.39e-1)" "unprognostic (9.14e-3)" "prognostic unfavorable (1.95e-4)" "unprognostic (1.28e-2)" "unprognostic (6.63e-3)" "unprognostic (2.19e-1)" "unprognostic (3.27e-1)" "unprognostic (4.51e-2)" "unprognostic (3.40e-1)" "unprognostic (2.72e-5)" "unprognostic (3.40e-2)" "unprognostic (2.79e-1)" "unprognostic (7.22e-2)" "unprognostic (3.16e-3)" 0.9 0.7 0.0 0.4 0.0 0.0 1.8 0.2 0.3 0.6 0.6 0.7 0.0 0.4 0.0 0.6 0.1 1.3 6540.8 0.0 0.2 0.7 1.6 48.6 2.5 0.0 0.2 0.7 4.8 0.2 1.1 4.2 0.0 6.8 0.0 0.0 8.7 0.1 571.0 2.3 0.6 2.1 0.0 0.5 1.0 0.9 0.8 1.5 1.7 20.5 0.0 1.2 0.5 0.1 37.2 10.8 6.6 0.3 5.8 6.7 0.5 21.5 2.2 6.0 10.8 474.5 17.9 0.3 1248.9 1.8 48.5 13.3 2.3 3.1 15.7 1.4 1.2 0.2 2.9 148.5 27.7 0.0 0.0 44.2 0.1 9.5 21.6 679.8 437.8 0.0 0.3 0.0 1573.6 0.4 0.0 0.0 1.3 2.7 0.3 0.0 104.3 0.0 3.9 0.5 0.1 0.0 0.3 0.4 1.2 469.1 0.3 1.9 2206.7 4.1 163.9 3.2 175.0 0.0 1.2 3.0 0.9 0.6 0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.2 0.0 0.2 0.0 0.0 0.8 0.1 0.0 913.5 42.0 0.0 0.0 0.0 3.5 18.5 0.0 0.0 0.0 0.0 13820.4 7.2 6.6 0.0 0.0 0.6 0.0 0.0 0.0 66.3 5.7 9.4 0.2 83.6 0.0 0.0 0.0 0.2 0.2 243.5 0.0 4.6 3.8 1.3 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.6 0.0 0.0 0.6 0.0 0.0 0.0 0.0 3.5 0.0 0.0 0.0 0.4 0.0 0.1 1.0 0.0 0.0 74.5 100.9 0.0 0.0 0.0 0.0 0.5 0.6 0.0 0.0 0.1 ANXA3 ANX3 ENSG00000138772 "Annexin A3" P12429 4 78551747-78610451 "FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Phospholipase A2 inhibitor" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 337.7" "Cell type enhanced" "Detected in many" "Adipocytes: 322.7;Alveolar cells type 1: 589.7;Ductal cells: 434.5;Exocrine glandular cells: 305.3;Pancreatic endocrine cells: 754.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 320 "neutrophil: 207.7" "Lineage enriched" "Detected in single" 327 "granulocytes: 207.7" "Cell line enhanced" "Detected in many" "A-431: 419.5;CACO-2: 403.5;CAPAN-2: 563.7;EFO-21: 334.7;hTERT-HME1: 566.3;OE19: 502.1;RPTEC TERT1: 477.8" "Low region specificity" "Detected in all" "HPA013398, HPA013431" Enhanced Supported "Plasma membrane" NA NA 6400000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 16: Pancreatic endocrine cells - Mixed function" "Plasma membrane" "HPA013398: AB_1844861, HPA013431: AB_1844862" "unprognostic (2.66e-1)" "unprognostic (5.65e-3)" "unprognostic (4.92e-3)" "unprognostic (8.67e-2)" "unprognostic (2.41e-1)" "unprognostic (5.02e-3)" "unprognostic (4.17e-2)" "unprognostic (1.87e-1)" "unprognostic (5.09e-2)" "unprognostic (2.10e-3)" "prognostic unfavorable (1.28e-4)" "unprognostic (4.82e-2)" "prognostic favorable (8.48e-6)" "unprognostic (2.23e-1)" "unprognostic (2.02e-2)" "unprognostic (7.20e-2)" "unprognostic (3.30e-2)" 52.9 3.1 16.5 22.7 17.3 337.7 43.8 14.5 28.2 19.6 11.7 27.7 15.8 12.5 3.7 55.2 16.8 17.3 51.2 14.2 21.6 24.9 3.9 144.4 2.4 19.9 16.1 2.5 32.7 34.0 5.9 81.5 20.8 68.0 26.7 1.6 119.5 12.9 28.3 10.0 13.3 20.1 14.6 21.6 90.5 1.9 19.9 7.1 83.7 36.7 12.7 10.2 15.6 14.7 419.5 77.7 1.3 0.9 1.0 0.9 0.6 4.9 0.4 11.0 10.9 403.5 563.7 0.1 334.7 14.4 0.4 161.6 0.1 300.0 16.0 1.4 3.3 36.4 142.0 23.9 45.9 5.9 0.2 2.4 262.6 4.1 566.3 60.1 118.9 9.0 0.7 0.3 1.9 15.9 1.7 0.2 13.0 502.1 55.4 0.0 0.8 0.0 477.8 45.2 0.3 0.3 235.5 58.2 16.6 186.1 9.9 4.3 153.2 0.6 52.6 0.2 93.0 3.1 5.1 2.2 0.0 0.4 0.1 0.6 0.2 0.0 0.0 0.1 0.0 0.5 0.0 0.0 0.0 0.4 0.1 0.0 207.7 0.1 0.6 0.1 0.0 2.9 16.5 17.3 14.5 28.2 14.2 21.6 19.9 16.1 20.8 14.6 19.9 14.7 322.7 589.7 47.3 0.0 1.1 24.9 81.8 144.9 1.8 0.2 27.6 85.9 8.6 55.8 175.2 38.6 0.0 212.6 1.0 35.4 17.6 434.5 1.1 33.7 4.4 84.6 5.4 3.2 0.9 305.3 106.2 16.9 99.9 58.1 5.1 0.1 23.2 0.6 18.9 0.0 0.3 33.4 122.1 0.3 0.3 0.3 3.1 6.9 5.4 42.2 21.0 1.2 0.0 1.0 0.6 754.2 61.6 0.4 0.6 158.6 11.5 5.5 89.6 0.4 0.0 7.6 18.7 1.1 0.6 21.9 6.7 62.8 2.3 1.3 29.7 46.7 AOAH ENSG00000136250 "Acyloxyacyl hydrolase" P28039 7 36512941-36724549 "Enzymes, Metabolic proteins, Predicted secreted proteins" "Lipid metabolism" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 43.3;lymphoid tissue: 64.9" "Cell type enhanced" "Detected in many" "dendritic cells: 77.9;Kupffer cells: 119.7;Macrophages: 77.1;Microglial cells: 233.3;monocytes: 67.5;NK-cells: 90.6;T-cells: 54.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "classical monocyte: 298.5" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "GAMG: 4.8;NB-4: 26.5;THP-1: 20.2;U-937: 8.9" "Not detected" "Not detected" "Low region specificity" "Detected in single" "HPA021666, HPA026716" Approved Uncertain Vesicles "Secreted to blood" NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 2: Immune cells - Immune response" "Cluster 24: NB-4 - Immune response" "Cluster 63: NK-cells & T-cells - Immune response" Vesicles "HPA021666: AB_2670799, HPA026716: AB_2671960" "unprognostic (3.55e-2)" "unprognostic (4.03e-3)" "unprognostic (4.45e-2)" "unprognostic (3.58e-1)" "unprognostic (6.06e-2)" "unprognostic (4.78e-2)" "unprognostic (2.40e-1)" "unprognostic (3.14e-3)" "unprognostic (5.42e-2)" "unprognostic (6.02e-2)" "unprognostic (3.36e-2)" "unprognostic (1.05e-1)" "unprognostic (1.46e-3)" "unprognostic (1.75e-1)" "unprognostic (1.92e-3)" "unprognostic (2.38e-1)" "unprognostic (1.35e-1)" 7.5 5.1 2.4 33.7 2.2 43.3 3.8 2.1 3.1 5.7 4.7 10.4 9.5 2.8 1.5 3.3 3.5 15.6 2.0 2.1 3.6 1.9 13.2 12.7 35.1 6.6 5.1 2.6 1.5 1.5 0.9 11.2 5.7 2.5 13.3 0.8 3.7 2.8 0.5 0.8 12.1 9.3 4.0 64.9 7.0 1.3 5.1 13.9 1.8 0.9 15.1 13.9 1.3 8.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.8 0.6 0.0 0.0 0.0 3.8 0.0 0.3 0.1 0.0 0.0 2.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.6 26.5 0.1 0.0 0.0 0.5 0.0 0.3 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 20.2 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 8.9 0.0 1.8 298.5 97.8 43.6 251.9 9.0 2.6 2.2 30.7 183.1 0.3 4.8 37.3 97.9 106.8 113.2 2.7 0.7 207.3 2.4 2.2 2.1 3.1 2.1 3.6 6.6 5.1 5.7 4.0 5.1 8.6 1.3 0.0 9.6 1.3 3.6 0.8 0.1 0.0 0.0 1.1 0.6 1.7 0.5 1.5 2.5 0.0 0.0 0.2 77.9 9.2 1.9 0.3 0.6 0.4 0.3 1.4 15.5 16.0 12.4 0.0 0.2 3.1 2.6 0.4 5.1 0.7 2.5 0.9 32.8 0.0 8.1 0.3 0.0 119.7 20.3 1.2 0.0 77.1 0.0 233.3 67.5 2.8 90.6 12.1 38.6 0.0 3.8 0.4 13.6 0.1 0.3 0.5 0.7 0.3 0.0 0.3 0.5 0.0 0.1 0.4 0.3 0.1 54.1 0.6 0.9 0.2 AOC1 "ABP, ABP1, DAO" ENSG00000002726 "Amine oxidase copper containing 1" P19801 7 150824627-150861504 "Enzymes, Metabolic proteins, Predicted secreted proteins" "Heparin-binding, Oxidoreductase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 16 "intestine: 227.2;kidney: 136.5;placenta: 496.7" "Cell type enhanced" "Detected in many" "Collecting duct cells: 272.2;Distal enterocytes: 517.5;Paneth cells: 532.1;Proximal enterocytes: 957.9" "Group enriched" "Detected in many" 5 "colorectal cancer: 61.3;endometrial cancer: 39.1;pancreatic cancer: 26.9;renal cancer: 69.4;stomach cancer: 43.2" "Not detected" "Not detected" "Immune cell enriched" "Detected in some" 12 "eosinophil: 31.2" "Lineage enriched" "Detected in many" 22 "granulocytes: 31.2" "Cell line enhanced" "Detected in some" "CAPAN-2: 20.5;HaCaT: 6.2;NB-4: 6.4;RPMI-8226: 7.7;THP-1: 27.1" "Low region specificity" "Detected in many" "HPA031032, HPA031033" Approved "Secreted in other tissues" NA NA 2500000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 43: THP-1 - Innate immune response" "Cluster 45: Enterocytes - Digestion" "HPA031032: AB_10670150, HPA031033: AB_10669670" "unprognostic (1.73e-2)" "unprognostic (2.53e-1)" "unprognostic (1.58e-2)" "unprognostic (2.84e-2)" "unprognostic (6.31e-3)" "unprognostic (8.31e-3)" "unprognostic (9.07e-3)" "unprognostic (6.42e-2)" "unprognostic (1.21e-1)" "unprognostic (1.96e-1)" "unprognostic (3.11e-1)" "prognostic favorable (1.71e-4)" "unprognostic (5.32e-3)" "unprognostic (3.62e-2)" "unprognostic (1.49e-2)" "unprognostic (1.69e-1)" "unprognostic (1.64e-1)" 0.7 0.1 0.3 13.0 0.2 1.9 0.2 0.3 0.3 7.2 0.4 142.2 184.0 2.1 1.9 3.3 0.1 1.8 0.7 0.3 0.2 136.5 5.8 0.6 1.3 0.5 0.5 0.3 1.4 0.0 0.0 496.7 0.5 6.1 94.1 0.1 0.6 1.0 0.1 1.4 227.2 3.4 0.3 0.5 18.0 2.1 0.6 2.1 0.2 0.0 3.8 0.8 0.4 0.5 0.0 0.1 0.1 0.4 0.0 0.0 1.0 0.2 0.0 0.0 0.0 3.2 20.5 0.0 2.7 0.0 1.7 6.2 0.0 0.1 0.0 0.1 0.0 0.1 0.2 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.4 0.0 0.3 0.1 6.4 0.2 1.9 0.0 0.0 0.0 7.7 0.3 0.2 2.2 2.5 0.1 0.9 0.0 0.3 0.8 27.1 0.6 0.2 0.1 0.6 0.0 0.2 0.1 0.1 0.2 1.0 0.1 0.2 0.1 31.2 0.0 0.1 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.1 0.3 0.2 0.3 0.3 0.3 0.2 0.5 0.5 0.5 0.3 0.6 0.5 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.8 0.0 0.8 272.2 0.0 2.1 0.0 517.5 15.6 0.0 7.1 1.9 0.5 0.4 43.3 0.0 0.1 3.3 63.4 0.5 13.7 4.8 5.7 0.0 0.0 0.0 2.8 0.0 0.1 129.7 2.0 0.0 1.7 18.4 0.0 1.0 0.0 0.0 66.2 0.0 0.0 0.0 0.0 3.7 532.1 0.0 0.0 0.7 957.9 145.2 0.2 0.0 0.0 0.0 0.3 3.7 1.3 0.0 0.1 3.4 0.9 0.0 117.9 0.3 AOC2 "DAO2, RAO" ENSG00000131480 "Amine oxidase copper containing 2" O75106 17 42844580-42850707 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Catecholamine metabolism" Oxidoreductase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in some" 5 "Early spermatids: 29.5" "Cancer enhanced" "Detected in some" "testis cancer: 3.8" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 5 "neutrophil: 1.1" "Lineage enriched" "Detected in single" 7 "granulocytes: 1.1" "Cell line enhanced" "Detected in many" "ASC diff: 11.2" "Low region specificity" "Detected in many" "Not detected" "Not detected" HPA057779 Uncertain "Intracellular and membrane" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 78: Testis - Spermatogenesis" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 29: Early spermatids - Spermatogenesis" "HPA057779: " "unprognostic (3.79e-2)" "unprognostic (2.33e-1)" "unprognostic (5.10e-4)" "unprognostic (1.90e-2)" "unprognostic (1.48e-2)" "unprognostic (2.42e-1)" "unprognostic (4.63e-2)" "unprognostic (2.63e-2)" "unprognostic (1.39e-1)" "unprognostic (3.64e-2)" "unprognostic (2.16e-2)" "unprognostic (8.27e-3)" "unprognostic (4.55e-5)" "unprognostic (3.55e-2)" "unprognostic (2.73e-1)" "unprognostic (1.63e-2)" "prognostic favorable (2.47e-4)" 5.8 1.1 1.9 0.6 2.1 0.9 2.6 1.9 3.2 1.3 0.6 1.3 0.3 1.0 0.5 0.7 1.6 0.7 0.7 2.4 1.9 1.2 3.4 2.3 0.5 2.0 1.6 1.1 0.7 0.2 2.0 0.4 2.0 1.5 0.2 1.5 0.6 0.5 1.6 1.3 0.8 0.6 1.1 1.6 0.8 4.8 2.0 0.3 0.9 0.6 0.6 1.8 1.2 1.9 0.2 2.3 0.5 2.5 11.2 1.1 6.0 0.8 0.7 1.6 2.2 1.8 0.2 0.9 1.1 0.2 0.7 1.0 2.2 0.6 3.2 2.0 6.0 0.3 1.3 1.9 0.7 0.3 2.2 1.7 2.0 1.5 2.3 0.4 0.4 3.1 0.6 2.1 0.4 0.3 0.5 0.9 0.8 0.2 0.7 1.1 2.3 1.9 0.3 3.6 0.8 0.5 0.1 0.8 3.4 4.6 0.4 0.2 0.4 1.5 3.2 2.0 1.0 4.6 4.9 0.9 0.4 2.2 0.8 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 1.9 2.1 1.9 3.2 2.4 1.9 2.0 1.6 2.0 1.1 2.0 1.9 1.1 0.0 0.5 1.6 0.3 1.0 0.5 0.1 0.0 0.5 0.9 0.9 0.4 0.0 0.7 0.0 2.1 0.1 0.4 0.0 0.0 0.3 29.5 1.4 0.7 1.4 0.0 0.0 1.8 0.4 0.1 0.2 0.0 2.8 0.0 0.5 0.4 0.7 0.1 0.0 1.2 0.2 0.0 0.3 0.6 5.0 0.3 0.3 0.0 0.0 0.0 0.2 0.0 0.0 0.5 0.2 0.1 0.0 0.0 1.2 0.1 0.2 0.4 0.8 0.0 0.5 1.0 2.3 2.1 0.4 1.6 0.0 0.2 0.4 0.2 0.6 AOC3 "HPAO, VAP-1, VAP1" ENSG00000131471 "Amine oxidase copper containing 3" Q16853 17 42851184-42858130 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Cell adhesion" Oxidoreductase "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adipose tissue: 422.8" "Group enriched" "Detected in many" 4 "Adipocytes: 58.2;Peritubular cells: 74.9;Sertoli cells: 118.3;Smooth muscle cells: 93.0;Theca cells: 74.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 17 "ASC diff: 307.5" "Not detected" "Not detected" "Low region specificity" "Detected in some" "HPA000980, CAB025797" Enhanced Approved "Golgi apparatus,Cytosol" "Secreted - unknown location" NA NA 240000000 "Cluster 46: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 48: Smooth muscle cells - ECM organization" Cytosol "Golgi apparatus" "CAB025797: , HPA000980: AB_1078170" "unprognostic (2.20e-1)" "unprognostic (4.49e-2)" "prognostic unfavorable (3.68e-4)" "unprognostic (2.97e-2)" "unprognostic (1.17e-1)" "unprognostic (2.64e-1)" "unprognostic (2.22e-1)" "unprognostic (2.15e-2)" "unprognostic (1.48e-1)" "unprognostic (4.00e-2)" "unprognostic (2.95e-1)" "unprognostic (9.02e-2)" "prognostic unfavorable (1.79e-5)" "unprognostic (5.61e-2)" "unprognostic (1.67e-1)" "unprognostic (8.39e-2)" "prognostic unfavorable (6.98e-4)" 422.8 48.4 2.6 31.9 3.2 1.4 169.2 2.5 4.2 52.8 2.7 210.8 17.3 95.1 33.5 88.0 84.8 50.7 50.2 2.9 2.5 24.1 19.1 218.6 12.4 2.5 2.5 26.5 12.0 8.4 5.4 28.0 2.6 59.1 41.0 1.7 14.7 103.6 17.8 24.6 57.6 144.8 2.3 21.4 66.6 12.8 2.4 5.9 28.2 22.9 3.9 142.1 50.9 2.5 0.1 1.5 0.2 1.0 307.5 0.3 5.0 0.3 0.1 0.2 0.8 0.9 0.0 0.7 0.7 0.1 0.2 0.5 0.8 0.2 0.8 1.5 5.7 0.4 0.5 18.4 0.8 0.3 1.0 3.3 1.0 0.3 0.8 0.0 0.2 2.2 0.3 1.7 0.6 0.2 0.2 1.4 0.7 0.1 0.4 0.7 0.8 3.0 0.1 2.2 0.3 0.4 0.0 0.2 2.0 2.2 0.1 0.1 0.0 0.3 2.7 1.2 0.4 4.8 5.9 0.6 0.4 2.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.6 3.2 2.5 4.2 2.9 2.5 2.5 2.5 2.6 2.3 2.4 2.5 58.2 3.2 6.0 0.0 0.5 2.9 0.1 0.0 2.2 0.0 1.1 2.2 9.5 0.0 1.9 0.0 0.0 0.1 0.4 0.1 0.0 0.2 4.5 0.8 2.3 12.3 0.0 0.0 0.4 0.2 0.1 11.3 0.0 1.4 1.3 2.1 20.7 0.2 1.4 0.0 0.3 0.1 0.0 1.4 2.7 2.6 3.4 0.9 3.6 3.7 0.0 0.2 0.0 0.0 0.1 0.2 0.0 74.9 0.0 0.4 0.1 1.4 1.0 0.4 118.3 2.6 93.0 1.1 1.3 0.7 1.8 0.3 0.6 74.6 0.1 0.3 AP000812.3 ENSG00000284844 "Novel protein, ortholog of mouse Tomt" 11 72105924-72109329 "Metabolic proteins, Predicted intracellular proteins" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ARAF ARAF1 ENSG00000078061 "A-Raf proto-oncogene, serine/threonine kinase" P10398 X 47561205-47571908 "Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA066326 Approved NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 27: Mucus-secreting cells - Mucin production" "HPA066326: AB_2685659" "unprognostic (1.21e-1)" "unprognostic (5.69e-3)" "unprognostic (2.47e-2)" "unprognostic (2.10e-2)" "unprognostic (7.63e-2)" "unprognostic (9.35e-2)" "unprognostic (1.79e-2)" "unprognostic (1.07e-1)" "unprognostic (3.76e-2)" "unprognostic (1.61e-1)" "unprognostic (6.75e-2)" "unprognostic (8.65e-2)" "prognostic favorable (1.45e-6)" "unprognostic (1.97e-1)" "unprognostic (2.01e-1)" "unprognostic (6.37e-2)" "unprognostic (4.71e-2)" 37.7 41.7 17.8 36.9 20.8 102.3 36.2 19.2 21.1 34.8 22.6 40.9 37.8 36.6 21.2 32.2 35.0 32.5 50.8 17.1 18.0 44.6 55.7 39.4 40.4 22.8 20.5 39.5 59.1 51.8 27.7 31.3 20.1 40.9 33.3 15.4 45.1 34.6 136.3 36.0 39.7 31.3 18.8 46.1 46.7 12.0 21.0 38.0 39.4 85.6 31.5 36.1 30.8 20.4 49.1 69.5 29.2 46.9 43.5 34.2 39.0 40.3 42.3 58.6 54.1 57.2 58.6 29.0 32.4 54.6 49.2 67.3 51.8 56.3 34.3 53.5 61.9 29.4 74.4 30.6 61.4 58.3 85.1 45.0 56.0 56.2 49.6 39.2 45.9 36.0 55.2 55.7 40.5 83.3 42.6 64.0 41.8 41.2 77.8 39.2 38.0 65.5 34.4 46.7 32.8 25.0 43.7 39.7 24.5 47.0 74.9 43.3 44.2 38.0 42.5 76.2 41.4 71.1 49.2 22.5 50.8 65.3 31.1 48.3 47.8 61.3 44.1 57.8 40.3 32.6 38.4 40.9 55.2 37.3 33.5 40.5 37.8 38.7 67.9 40.4 41.6 50.8 17.8 20.8 19.2 21.1 17.1 18.0 22.8 20.5 20.1 18.8 21.0 20.4 13.3 16.0 29.2 7.5 25.8 15.7 25.0 29.0 18.2 5.3 15.0 9.8 25.1 34.3 22.0 18.4 10.4 33.0 26.3 43.8 23.5 29.3 1.3 11.4 10.8 17.5 31.8 22.3 5.0 34.3 30.4 16.9 39.3 15.6 16.5 13.6 24.3 42.6 28.0 13.5 5.5 35.9 40.7 26.4 21.6 4.3 17.4 25.8 33.8 4.7 43.7 18.4 32.0 8.5 8.9 26.2 41.5 17.7 27.9 20.3 44.6 27.1 11.5 9.0 19.7 15.9 18.0 8.2 10.5 17.7 16.2 44.6 26.5 12.5 32.3 24.6 AS3MT CYT19 ENSG00000214435 "Arsenite methyltransferase" Q9HBK9 10 102869470-102901899 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "adrenal gland: 302.4" "Cell type enhanced" "Detected in some" "Alveolar cells type 2: 1.1;Basal squamous epithelial cells: 1.2;Proximal tubular cells: 1.0" "Cancer enhanced" "Detected in single" "liver cancer: 1.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 26.8;REH: 54.6;SH-SY5Y: 27.8;T-47d: 43.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017856 Enhanced Approved Mitochondria NA NA "Cluster 17: Adrenal gland - Steroid metabolism" "Cluster 6: T47d - Mammary gland" "Cluster 50: Fibroblasts - ECM organization" Mitochondria "HPA017856: AB_1847420" "unprognostic (1.11e-1)" "unprognostic (2.02e-4)" "unprognostic (2.45e-1)" "unprognostic (2.25e-1)" "unprognostic (3.39e-1)" "unprognostic (1.66e-1)" "unprognostic (7.02e-4)" "unprognostic (3.22e-1)" "unprognostic (1.42e-1)" "unprognostic (3.90e-2)" "unprognostic (2.03e-1)" "unprognostic (1.83e-1)" "unprognostic (3.83e-10)" "unprognostic (1.04e-2)" "unprognostic (4.17e-2)" "unprognostic (1.59e-1)" "unprognostic (2.16e-2)" 5.1 302.4 7.4 1.3 7.5 0.7 6.3 11.5 8.7 7.5 9.3 6.4 3.0 7.7 4.4 3.6 5.8 6.7 26.8 6.7 8.4 19.2 59.2 4.0 2.0 7.9 8.3 8.7 11.7 65.7 6.6 1.0 8.0 9.1 1.8 4.8 4.8 5.2 11.4 4.3 3.3 3.9 6.6 18.3 4.7 8.7 7.7 3.7 7.7 15.2 1.6 3.2 5.0 8.3 0.0 7.6 26.8 17.4 0.6 0.6 5.1 8.1 6.7 11.9 14.3 21.3 1.2 0.0 2.4 10.7 0.6 0.4 23.8 1.4 12.4 0.3 6.7 0.0 3.2 20.9 7.7 0.2 0.6 3.7 3.1 1.6 0.0 21.3 0.5 25.3 0.0 0.4 10.8 0.1 4.9 0.7 13.2 0.1 1.0 54.6 0.0 0.2 2.7 0.0 0.4 27.8 0.0 0.4 3.7 8.8 43.9 0.6 0.1 2.6 0.0 3.9 0.0 0.2 0.4 0.0 8.6 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 7.4 7.5 11.5 8.7 6.7 8.4 7.9 8.3 8.0 6.6 7.7 8.3 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.3 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.3 0.0 0.0 ASPH "BAH, CASQ2BP1, HAAH, JCTN" ENSG00000198363 "Aspartate beta-hydroxylase" Q12797 8 61500556-61714640 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Dioxygenase, Oxidoreductase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adipose tissue: 386.9" "Cell type enhanced" "Detected in all" "Muller glia cells: 468.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "plasmacytoid DC: 34.0" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-87 MG: 890.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA055161, HPA059303" Uncertain Enhanced "Endoplasmic reticulum" NA NA 1100000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 20: HeLa - Mitochondria" "Cluster 5: Muller glia cells - Visual perception" "Endoplasmic reticulum" "HPA055161: AB_2682721, HPA059303: AB_2683973" "unprognostic (8.07e-2)" "prognostic unfavorable (8.07e-5)" "unprognostic (1.73e-2)" "unprognostic (4.48e-2)" "unprognostic (2.32e-1)" "unprognostic (1.85e-2)" "unprognostic (2.82e-2)" "prognostic unfavorable (3.61e-4)" "unprognostic (6.39e-2)" "unprognostic (3.64e-1)" "prognostic unfavorable (1.75e-4)" "unprognostic (9.50e-2)" "prognostic unfavorable (1.57e-5)" "unprognostic (8.96e-2)" "unprognostic (1.65e-1)" "prognostic unfavorable (4.24e-4)" "unprognostic (2.74e-2)" 386.9 160.3 64.7 50.6 69.2 16.9 106.9 102.3 88.9 65.6 84.4 78.8 45.6 49.3 44.7 71.4 46.9 61.0 111.3 64.5 58.4 59.5 74.9 74.1 20.3 54.0 69.2 62.2 44.7 38.7 36.3 47.9 52.2 48.3 84.9 219.5 101.9 70.2 357.6 35.2 45.5 67.5 44.8 28.6 105.0 16.5 71.8 16.7 97.0 182.7 28.5 112.2 43.8 60.4 460.3 652.3 89.9 55.1 392.1 370.1 31.2 804.0 741.3 336.3 350.1 113.1 594.2 35.3 54.3 474.6 270.3 167.5 56.2 281.1 570.0 13.6 57.0 81.1 372.5 310.3 251.2 12.5 12.9 306.5 61.9 187.6 237.4 657.2 144.8 18.0 22.2 32.1 300.2 97.4 3.3 16.6 51.7 441.6 383.4 22.3 97.0 7.3 206.2 374.0 93.1 32.1 249.9 116.1 101.7 49.0 47.7 22.2 456.7 338.0 174.3 313.0 288.0 20.2 27.1 1.5 890.1 7.5 231.4 1.9 8.3 0.3 2.5 2.9 4.7 5.5 3.5 2.4 10.0 5.0 4.9 2.5 25.4 8.7 1.8 34.0 4.0 4.1 64.7 69.2 102.3 88.9 64.5 58.4 54.0 69.2 52.2 44.8 71.8 60.4 79.1 195.5 244.0 366.6 13.8 47.0 160.7 126.0 68.9 138.3 83.7 58.4 228.6 37.1 157.5 86.5 294.0 118.1 40.3 57.0 15.6 144.2 1.6 51.4 65.8 85.9 116.5 13.0 93.1 180.4 107.1 132.0 73.9 115.4 8.2 34.5 42.8 62.6 72.2 127.9 98.9 215.1 52.9 26.6 44.1 3.1 70.8 48.1 42.7 61.8 20.0 468.8 2.1 154.8 53.5 257.7 32.3 57.6 15.9 148.2 34.3 34.6 66.6 158.8 46.0 114.4 92.7 3.4 16.8 101.7 50.3 48.0 13.6 131.2 67.3 254.2 ATE1 ENSG00000107669 "Arginyltransferase 1" O95260 10 121740424-121928492 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Oligodendrocyte precursor cells: 137.7;Oligodendrocytes: 220.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038444, HPA057549" Approved Supported Nucleoplasm NA NA 83000 "Cluster 18: Basophils - Vesicular transport" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA038444: AB_10672745, HPA057549: AB_2683463" "unprognostic (1.37e-1)" "unprognostic (5.19e-2)" "unprognostic (2.75e-3)" "unprognostic (2.40e-1)" "unprognostic (4.67e-2)" "unprognostic (6.65e-3)" "unprognostic (1.85e-1)" "unprognostic (1.42e-1)" "unprognostic (1.71e-1)" "unprognostic (1.00e-1)" "unprognostic (2.52e-1)" "unprognostic (5.69e-2)" "prognostic favorable (2.67e-4)" "unprognostic (3.20e-1)" "unprognostic (8.08e-2)" "unprognostic (2.16e-1)" "unprognostic (1.02e-1)" 10.1 11.7 8.1 8.5 8.5 7.4 10.4 7.3 9.2 12.1 17.3 13.5 11.4 10.6 8.4 10.7 9.0 10.4 22.2 8.4 11.0 18.2 18.2 9.5 9.5 6.7 7.3 10.0 6.2 15.4 4.8 11.0 7.5 12.7 14.6 15.6 7.8 10.0 18.3 6.7 11.1 11.7 7.4 10.4 8.8 13.3 10.6 13.0 16.0 15.4 10.6 12.7 6.6 8.7 13.0 19.5 15.4 15.0 15.1 16.8 12.3 12.0 24.0 13.1 13.2 23.6 19.1 16.1 9.5 14.3 8.8 16.1 14.5 14.2 16.3 20.3 13.1 5.8 8.8 31.1 15.5 26.7 13.4 11.9 15.2 13.8 32.0 19.3 18.7 9.0 7.8 29.4 14.5 7.9 14.0 15.2 7.5 19.6 11.4 13.1 18.1 10.6 23.4 11.2 4.8 19.4 17.2 12.9 28.2 11.3 8.9 9.2 19.2 8.2 7.0 12.5 21.1 28.0 33.6 12.0 12.6 20.6 7.4 12.8 3.8 6.1 5.3 4.5 6.3 4.5 5.0 5.3 3.4 4.2 5.5 5.6 2.3 5.1 3.5 4.8 6.7 4.0 8.1 8.5 7.3 9.2 8.4 11.0 6.7 7.3 7.5 7.4 10.6 8.7 23.0 9.6 22.0 76.4 17.3 8.4 12.8 9.4 24.5 31.3 17.5 14.6 75.6 11.5 12.7 20.2 12.5 7.2 20.9 42.8 17.6 11.3 6.5 15.8 19.4 19.3 22.1 16.2 100.5 13.3 10.5 25.0 29.6 16.4 12.6 13.5 20.0 26.6 10.0 23.5 93.8 17.7 10.2 14.8 7.2 7.7 20.5 23.6 14.2 74.0 12.8 21.7 27.8 137.7 220.4 15.6 18.3 25.9 24.8 21.0 19.5 39.4 11.5 35.8 0.0 23.4 21.1 26.9 40.2 30.7 17.5 8.6 17.9 29.1 16.8 16.6 ATM "ATA, ATC, ATD, ATDC, TEL1, TELO1" ENSG00000149311 "ATM serine/threonine kinase" Q13315 11 108222832-108369102 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, DNA damage" "DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Neurodegeneration, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 210.6;NK-cells: 339.8;Oligodendrocytes: 217.6;Rod photoreceptor cells: 200.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 78.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000102, HPA067142" Supported Supported Nucleoplasm,Vesicles NA NA "Cluster 44: Non-specific - Transcription" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 63: NK-cells & T-cells - Immune response" Nucleoplasm Vesicles "CAB000102: , HPA067142: AB_2685789" "unprognostic (9.77e-2)" "unprognostic (1.47e-1)" "unprognostic (3.04e-1)" "unprognostic (2.36e-1)" "unprognostic (5.70e-2)" "unprognostic (2.86e-2)" "unprognostic (6.32e-3)" "unprognostic (1.05e-1)" "unprognostic (8.19e-2)" "unprognostic (1.63e-1)" "unprognostic (7.68e-2)" "unprognostic (6.16e-2)" "unprognostic (2.17e-3)" "unprognostic (3.10e-1)" "unprognostic (7.87e-2)" "unprognostic (1.21e-1)" "unprognostic (2.81e-1)" 6.2 7.4 8.2 17.5 15.0 16.2 8.5 17.0 12.3 8.7 16.1 6.7 5.2 10.0 9.9 4.0 7.5 8.2 7.0 7.3 11.3 5.8 7.8 7.6 33.7 15.8 13.1 15.8 14.8 9.3 12.1 8.0 17.0 6.3 7.0 20.6 11.4 6.1 4.4 7.5 12.6 6.9 10.3 22.2 8.6 5.2 12.7 18.2 8.8 6.0 25.9 7.1 6.9 28.8 4.3 6.8 14.8 7.6 20.2 29.1 3.1 10.9 13.5 6.4 11.3 7.1 10.3 18.3 14.0 10.2 9.6 7.7 11.6 10.8 9.0 12.3 5.7 15.2 8.7 10.2 10.5 16.4 17.0 18.3 6.3 10.0 21.2 15.2 14.1 16.5 12.4 9.9 14.3 3.4 10.6 18.5 9.8 8.6 7.4 9.7 9.7 24.9 8.1 7.5 9.0 10.5 11.1 4.7 20.6 13.2 9.3 10.1 23.7 15.8 8.4 7.3 9.0 6.2 7.0 78.3 7.0 19.0 18.8 21.3 5.5 4.0 16.5 5.7 11.1 11.6 11.7 12.5 2.6 13.0 21.1 20.4 9.9 9.7 13.3 6.2 6.1 5.3 8.2 15.0 17.0 12.3 7.3 11.3 15.8 13.1 17.0 10.3 12.7 28.8 23.7 38.5 20.8 62.7 146.4 12.6 17.5 21.1 28.5 111.0 19.6 14.2 39.9 12.8 19.5 22.0 210.6 16.9 140.2 4.2 5.9 9.9 19.2 14.4 52.1 25.9 20.4 39.1 70.2 12.3 13.2 39.0 12.8 20.9 13.3 45.9 32.9 23.3 29.1 60.6 82.8 14.9 26.4 96.4 34.0 5.1 39.4 69.2 26.6 178.9 63.2 27.3 339.8 85.5 217.6 7.6 7.6 27.8 96.5 9.1 8.9 11.1 16.0 200.1 26.3 41.4 29.2 31.5 37.4 15.8 12.4 4.2 147.7 52.3 11.5 10.2 ATR "FRP1, MEC1, SCKL, SCKL1" ENSG00000175054 "ATR serine/threonine kinase" Q13535 3 142449007-142578733 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "DNA damage, DNA repair" "DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Dwarfism, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 93.0;Inhibitory neurons: 94.4;Microglial cells: 73.1;Oligodendrocyte precursor cells: 65.4;Oligodendrocytes: 71.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054320 Supported "Nucleoplasm,Golgi apparatus" No No "Cluster 15: NK-cells - Transcription" "Cluster 17: Adrenal gland - Steroid metabolism" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "Golgi apparatus" "HPA054320: AB_2682448" "unprognostic (1.47e-1)" "unprognostic (8.90e-2)" "unprognostic (2.90e-1)" "unprognostic (4.23e-2)" "unprognostic (2.25e-2)" "unprognostic (6.42e-2)" "prognostic unfavorable (8.39e-5)" "unprognostic (3.44e-1)" "unprognostic (1.67e-1)" "unprognostic (3.02e-1)" "prognostic unfavorable (1.23e-5)" "unprognostic (1.94e-1)" "unprognostic (5.61e-2)" "unprognostic (1.06e-1)" "unprognostic (3.55e-1)" "unprognostic (1.69e-2)" "unprognostic (1.43e-1)" 3.0 8.6 0.7 4.1 1.1 1.2 3.2 0.9 1.4 3.8 3.7 2.7 1.7 3.3 2.3 3.1 3.3 3.4 2.3 1.2 1.9 3.7 3.6 2.9 4.8 1.5 1.2 2.7 3.8 5.2 3.7 3.1 1.4 3.0 2.9 2.9 3.5 2.5 2.9 2.7 3.1 3.2 1.0 4.2 2.8 5.2 1.2 4.9 5.0 1.4 4.6 4.1 2.7 1.2 28.6 13.2 7.1 7.0 9.6 13.6 8.8 14.8 8.4 10.1 9.7 6.4 6.8 19.9 14.6 10.1 14.6 16.1 10.9 12.8 15.0 7.5 7.9 11.9 8.2 4.1 4.2 20.5 5.3 9.8 4.8 9.5 10.3 5.8 11.6 8.7 8.2 7.5 9.6 7.5 13.9 2.6 7.3 15.6 9.6 11.8 12.5 13.5 6.3 11.1 5.2 5.1 28.6 8.3 8.0 7.8 12.0 5.4 14.6 10.5 4.9 12.3 15.2 10.8 7.4 18.5 13.8 6.5 8.5 0.0 0.3 0.0 0.5 0.4 1.0 0.1 0.3 0.5 0.7 0.3 0.4 0.4 0.0 1.3 0.2 0.2 0.4 0.2 0.7 1.1 0.9 1.4 1.2 1.9 1.5 1.2 1.4 1.0 1.2 1.2 11.5 6.4 10.6 39.2 22.4 4.0 7.2 8.8 14.2 14.1 9.2 6.5 7.6 5.7 10.1 3.7 37.5 7.7 14.9 3.5 0.0 5.9 16.4 18.8 18.6 10.2 7.7 14.5 93.0 4.9 3.6 8.3 14.8 10.3 1.3 16.3 7.9 7.3 6.4 8.4 94.4 4.8 14.2 9.4 4.0 8.7 6.5 12.8 10.6 73.1 12.0 6.0 9.2 65.4 71.9 6.4 1.8 7.2 23.1 8.1 1.9 6.5 25.4 23.6 0.0 14.6 9.8 50.1 18.5 14.7 4.5 5.1 15.1 13.8 7.6 6.1 AUH ENSG00000148090 "AU RNA binding methylglutaconyl-CoA hydratase" Q13825 9 91213815-91361918 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Branched-chain amino acid catabolism" "Lyase, RNA-binding" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal tubular cells: 191.7;Inhibitory neurons: 137.0;Oligodendrocytes: 137.5;Proximal tubular cells: 120.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 82.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004171 Enhanced "Intracellular and membrane" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 1: Thyroid gland - Transcription" "Cluster 44: HDLM-2 - Immune response" "Cluster 39: Non-specific - Basic cellular processes" "HPA004171: AB_1845215" "unprognostic (4.10e-2)" "unprognostic (8.95e-2)" "unprognostic (5.56e-2)" "unprognostic (1.19e-1)" "unprognostic (1.54e-1)" "unprognostic (1.49e-1)" "unprognostic (3.24e-2)" "unprognostic (3.05e-2)" "unprognostic (3.57e-1)" "unprognostic (1.11e-3)" "unprognostic (1.41e-1)" "unprognostic (1.76e-1)" "prognostic favorable (0.00e+0)" "unprognostic (8.23e-3)" "unprognostic (2.84e-2)" "unprognostic (1.23e-1)" "unprognostic (1.23e-1)" 17.2 41.9 11.8 6.3 12.3 4.8 15.9 16.0 15.3 13.6 17.9 17.2 23.8 10.2 14.2 8.6 12.4 10.7 38.9 12.1 14.3 62.9 26.4 10.3 7.6 14.8 13.6 13.4 25.5 45.4 10.4 16.1 15.2 28.2 17.2 21.4 26.1 14.8 24.2 8.7 20.1 8.6 12.2 8.0 22.7 5.5 14.1 9.0 21.0 29.2 7.7 9.1 9.8 15.0 9.1 8.7 12.0 6.2 14.5 15.5 18.5 8.0 10.0 6.1 7.0 5.0 11.4 10.6 8.1 8.5 18.2 13.0 18.1 10.1 8.7 82.6 15.4 7.3 9.7 29.6 11.1 10.6 7.3 13.1 12.5 4.9 16.8 14.3 7.6 10.7 10.3 15.5 7.2 8.8 14.6 23.8 15.0 22.2 12.5 8.5 9.6 18.6 26.6 4.8 12.2 8.8 11.9 28.3 15.6 27.1 5.2 6.9 7.8 6.1 7.6 9.0 7.8 17.7 16.1 3.6 9.6 8.5 4.2 17.9 5.2 18.2 7.2 3.6 8.1 8.4 7.8 10.4 4.6 11.8 9.6 9.1 7.4 10.8 2.5 6.3 10.8 6.5 11.8 12.3 16.0 15.3 12.1 14.3 14.8 13.6 15.2 12.2 14.1 15.0 9.6 0.0 7.7 75.1 11.2 5.2 24.5 27.7 12.5 18.7 15.8 13.5 37.2 27.1 19.1 27.6 25.0 44.6 11.5 27.0 191.7 29.6 3.1 11.5 11.1 11.1 22.9 28.8 101.2 16.1 28.9 14.2 19.4 16.0 1.3 14.5 11.0 18.3 13.4 13.5 137.0 17.3 38.7 8.9 4.7 1.1 14.3 8.9 12.4 67.5 29.1 9.5 18.6 100.5 137.5 12.5 23.5 11.3 18.4 36.8 59.4 120.0 15.8 34.4 13.1 11.9 11.5 8.7 10.5 16.1 4.1 36.4 12.9 11.6 25.0 24.2 AURKA "AIK, ARK1, AurA, BTAK, PPP1R47, STK15, STK6, STK7" ENSG00000087586 "Aurora kinase A" O14965 20 56369389-56392337 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Cilium biogenesis/degradation, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 22.1;testis: 30.8" "Cell type enhanced" "Detected in many" "Erythroid cells: 81.6;Extravillous trophoblasts: 67.1;granulocytes: 54.1;Spermatocytes: 168.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB001454, HPA002636" Enhanced Approved "Nucleoplasm,Mitotic spindle,Centrosome,Cytosol" Yes Yes "Cluster 7: Monocytes - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" "Nucleoplasm, Centrosome" "Mitotic spindle, Cytosol" "CAB001454: AB_563420, HPA002636: AB_1845217" "unprognostic (7.73e-2)" "unprognostic (2.46e-2)" "unprognostic (2.76e-2)" "prognostic unfavorable (9.40e-5)" "unprognostic (1.92e-1)" "unprognostic (2.11e-2)" "prognostic unfavorable (1.49e-4)" "unprognostic (4.69e-3)" "unprognostic (2.42e-1)" "unprognostic (6.88e-2)" "prognostic unfavorable (6.13e-4)" "unprognostic (1.40e-1)" "prognostic unfavorable (1.47e-8)" "unprognostic (1.67e-1)" "unprognostic (6.83e-2)" "unprognostic (9.00e-2)" "unprognostic (5.14e-2)" 1.3 2.3 1.3 10.4 1.6 15.3 2.2 2.4 1.4 1.4 0.6 10.8 11.7 1.5 0.8 7.5 1.2 2.0 5.3 0.8 1.0 2.3 5.0 2.2 20.9 1.7 1.2 8.4 2.0 1.8 0.6 8.1 1.4 1.1 12.9 3.0 1.9 1.3 8.7 3.5 9.3 4.9 1.3 5.2 4.9 30.8 1.6 20.2 1.4 8.2 22.1 2.9 2.6 1.3 179.9 127.2 84.5 61.2 4.9 10.8 106.3 145.2 66.8 339.7 142.9 361.4 124.8 58.4 96.2 59.2 176.2 142.2 152.4 96.4 360.0 52.4 57.5 102.6 128.9 229.8 2.8 140.4 140.4 5.1 10.1 117.3 104.5 26.7 80.7 93.2 121.8 45.3 146.9 182.1 85.3 108.9 78.3 145.6 129.8 62.9 163.4 65.9 56.0 46.8 73.9 39.6 200.5 228.8 94.2 77.3 137.9 86.1 47.1 149.7 145.3 83.0 208.6 62.3 78.9 100.5 80.5 80.9 127.0 0.2 3.5 4.3 1.2 5.9 1.8 2.5 2.0 1.1 3.7 0.8 0.9 0.9 2.3 1.4 3.4 0.8 4.7 1.7 1.3 1.6 2.4 1.4 0.8 1.0 1.7 1.2 1.4 1.3 1.6 1.3 2.5 0.0 2.8 0.3 7.4 1.1 1.2 5.6 0.6 1.0 4.3 6.2 5.6 1.5 2.3 3.7 2.1 34.5 8.3 8.3 1.9 4.0 33.9 2.0 2.3 3.1 6.0 81.6 1.1 4.9 67.1 7.0 13.7 3.4 54.1 12.3 3.6 2.6 17.5 1.7 1.5 10.8 2.0 3.5 7.6 16.3 1.5 11.7 0.0 1.0 12.0 3.7 3.1 1.0 2.0 5.2 2.8 0.4 10.1 2.0 5.1 4.2 1.5 2.7 6.6 2.2 7.7 168.2 30.8 8.3 1.1 8.2 8.0 8.7 15.5 1.5 AURKB "Aik2, AIM-1, ARK2, AurB, IPL1, PPP1R48, STK12, STK5" ENSG00000178999 "Aurora kinase B" Q96GD4 17 8204733-8210600 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 44.1;lymphoid tissue: 60.1" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 40.5;Erythroid cells: 59.3;Extravillous trophoblasts: 89.1;Granulosa cells: 24.7;Hofbauer cells: 29.4" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Immune cell enhanced" "Detected in some" "T-reg: 7.9" "Group enriched" "Detected in many" 6 "B-cells: 2.5;T-cells: 7.9" "Low cell line specificity" "Detected in many" "Group enriched" "Detected in some" 5 "basal ganglia: 1.3;white matter: 4.0" "Low region specificity" "Detected in all" "CAB005862, HPA037708" Enhanced Enhanced Nucleoplasm,Midbody Yes Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm Midbody "CAB005862: AB_449204, HPA037708: AB_2675623" "unprognostic (4.76e-2)" "unprognostic (3.61e-3)" "unprognostic (2.25e-1)" "unprognostic (3.14e-2)" "unprognostic (2.27e-1)" "unprognostic (6.05e-2)" "prognostic unfavorable (1.24e-4)" "unprognostic (1.99e-3)" "unprognostic (9.41e-3)" "unprognostic (3.47e-2)" "unprognostic (4.61e-3)" "unprognostic (1.01e-2)" "prognostic unfavorable (0.00e+0)" "unprognostic (7.77e-2)" "unprognostic (2.93e-1)" "unprognostic (6.76e-2)" "unprognostic (3.77e-1)" 1.1 1.2 0.1 14.2 0.2 44.1 1.7 0.2 0.2 3.0 0.1 11.1 12.1 1.6 0.4 18.6 0.6 1.5 0.7 0.1 0.2 0.9 2.0 2.5 36.7 0.1 0.3 0.5 0.6 0.3 0.2 8.2 0.3 0.8 11.0 0.0 2.7 0.3 5.5 9.3 11.6 3.2 0.0 12.0 4.6 1.2 0.4 60.1 0.6 0.0 36.6 3.5 5.9 0.2 196.5 130.9 191.1 93.0 4.2 6.5 73.4 91.7 49.5 186.2 170.6 171.5 57.4 193.3 46.2 37.0 77.0 139.8 140.1 62.6 153.7 84.9 231.3 115.7 78.3 146.1 0.7 62.2 109.2 3.5 2.9 109.4 67.7 18.5 86.5 123.6 73.3 73.4 82.9 92.9 225.1 87.4 119.6 63.9 57.6 149.8 176.1 80.5 41.2 38.2 41.2 59.1 81.7 36.5 61.2 56.5 63.5 41.4 33.9 74.3 75.6 67.6 243.3 53.2 37.7 147.9 35.7 92.9 153.4 0.0 0.4 0.6 0.5 0.3 0.1 1.1 1.3 2.1 0.5 2.5 0.1 0.7 0.9 0.3 0.2 0.2 7.9 0.9 0.1 0.2 0.2 0.2 0.1 0.2 0.1 0.3 0.3 0.0 0.4 0.2 0.3 0.0 0.5 0.0 7.6 4.5 1.8 6.1 0.6 0.0 1.8 2.2 1.4 0.0 2.6 0.0 0.0 40.5 1.8 13.2 0.0 0.4 0.1 0.5 1.6 3.1 0.0 59.3 0.0 0.0 89.1 5.7 6.1 2.1 4.5 24.7 6.1 0.7 29.4 0.0 0.0 10.8 0.0 5.7 7.3 0.2 0.6 5.1 1.8 0.0 0.9 0.0 3.1 0.0 0.1 0.3 2.8 0.0 15.4 1.2 1.5 0.1 0.2 0.0 0.0 0.1 4.8 1.6 7.2 11.8 2.4 9.0 4.3 1.0 22.0 2.8 AURKC "ARK3, AurC, STK13" ENSG00000105146 "Aurora kinase C" Q9UQB9 19 57230802-57235548 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Meiosis, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 7 "testis: 46.9" "Group enriched" "Detected in many" 4 "Early spermatids: 150.2;Spermatocytes: 116.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 7 "NTERA-2: 38.4" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA034859 Uncertain NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 78: Testis - Spermatogenesis" "Cluster 5: NTERA-2 - Transcription" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA034859: AB_10670298" "unprognostic (7.27e-2)" "unprognostic (1.76e-1)" "unprognostic (6.45e-2)" "unprognostic (8.07e-3)" "unprognostic (3.29e-1)" "unprognostic (5.99e-2)" "unprognostic (1.11e-2)" "unprognostic (7.02e-2)" "unprognostic (1.13e-1)" "unprognostic (2.09e-1)" "unprognostic (1.47e-2)" "unprognostic (2.51e-1)" "unprognostic (1.20e-5)" "unprognostic (4.26e-2)" "unprognostic (1.61e-1)" "unprognostic (1.55e-1)" "unprognostic (6.46e-4)" 1.2 1.1 3.5 1.3 3.7 1.4 2.0 3.8 6.3 0.7 3.0 1.0 0.2 1.3 1.8 1.0 1.1 1.4 1.9 3.5 3.5 1.5 2.7 1.1 3.4 3.7 3.6 0.5 0.9 0.6 1.4 1.9 3.9 0.9 1.3 1.1 0.8 1.4 1.9 1.2 0.8 1.1 3.8 5.0 0.8 46.9 3.7 1.2 1.2 0.5 2.2 1.4 0.8 4.3 0.3 0.1 0.9 0.4 0.3 0.9 0.5 1.7 0.8 1.2 4.4 1.3 0.2 0.1 0.2 0.6 1.0 0.0 0.0 0.9 0.8 0.0 4.9 0.2 0.4 0.0 1.4 0.0 0.3 1.2 0.9 0.9 0.7 1.5 0.8 0.5 0.2 0.0 1.6 0.0 1.5 0.9 38.4 0.2 1.0 0.1 0.3 0.8 0.9 1.7 1.9 0.6 0.0 0.3 0.2 0.1 0.1 1.8 0.4 0.3 5.1 0.4 1.0 1.9 2.7 0.8 1.1 0.0 0.1 0.0 0.0 0.4 0.1 0.2 0.0 0.3 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 3.5 3.7 3.8 6.3 3.5 3.5 3.7 3.6 3.9 3.8 3.7 4.3 1.9 0.0 0.5 0.7 0.1 1.1 0.8 0.9 0.0 2.4 1.2 3.8 1.2 0.0 2.5 1.8 0.0 0.4 0.9 0.7 1.9 2.1 150.2 0.8 0.4 0.8 1.8 0.4 1.3 1.0 0.9 1.0 0.0 0.6 0.0 0.5 1.8 0.6 4.1 0.0 1.3 0.3 0.0 2.6 0.8 28.9 1.5 1.2 5.4 0.0 1.0 1.8 1.0 0.0 0.9 1.3 1.4 0.4 0.6 1.3 0.0 0.5 2.7 1.0 6.6 0.4 0.7 116.8 22.9 0.5 1.1 0.3 0.9 0.5 0.4 1.6 BARD1 ENSG00000138376 "BRCA1 associated RING domain 1" Q99728 2 214725646-214809683 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 68.6;Basal prostatic cells: 62.2;Suprabasal keratinocytes: 74.4;Urothelial cells: 67.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB034106, HPA035354, HPA044864" Enhanced Supported "Nucleoplasm,Nuclear speckles,Cytoplasmic bodies" No Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Nuclear speckles" "Cytoplasmic bodies" "CAB034106: AB_2061237, HPA035354: AB_2674585, HPA044864: AB_2679119" "unprognostic (4.85e-2)" "unprognostic (1.87e-2)" "unprognostic (1.74e-2)" "unprognostic (8.37e-3)" "unprognostic (2.57e-2)" "unprognostic (1.03e-2)" "unprognostic (6.25e-4)" "unprognostic (1.99e-1)" "unprognostic (2.16e-2)" "unprognostic (3.92e-3)" "unprognostic (2.80e-2)" "unprognostic (7.41e-2)" "unprognostic (1.94e-8)" "unprognostic (3.94e-2)" "unprognostic (2.28e-1)" "unprognostic (1.57e-1)" "unprognostic (1.08e-1)" 1.8 0.6 3.0 2.7 4.6 11.4 2.9 2.2 2.7 3.1 0.2 2.9 2.3 3.3 2.6 5.1 1.9 2.0 1.5 2.3 4.1 0.8 1.0 2.5 5.5 3.8 3.2 2.3 1.6 2.3 1.2 2.3 3.9 2.9 3.6 2.0 1.9 3.6 4.2 8.8 2.1 3.9 3.9 2.6 1.9 6.6 4.1 7.0 1.4 2.3 6.6 2.1 3.8 4.2 12.3 8.8 20.2 9.3 2.7 4.0 12.0 17.3 10.6 17.8 21.8 12.0 12.2 12.6 7.6 8.5 9.5 12.7 16.5 10.5 22.7 11.5 6.4 12.5 13.8 8.7 0.9 13.9 12.7 4.7 1.1 15.0 8.1 4.5 6.1 14.7 7.9 36.0 13.7 10.7 27.9 12.5 14.3 7.9 3.7 24.7 19.8 11.2 3.9 14.0 5.8 8.8 15.0 14.7 5.3 10.9 16.3 13.4 4.7 18.0 14.0 11.7 13.6 10.2 12.6 28.0 7.6 11.3 13.4 3.9 2.0 5.8 4.6 4.0 3.2 9.7 5.4 5.5 3.6 8.2 2.4 4.0 0.3 7.3 3.8 6.9 17.1 2.3 3.0 4.6 2.2 2.7 2.3 4.1 3.8 3.2 3.9 3.9 4.1 4.2 12.3 6.4 2.2 14.7 13.0 68.6 62.2 13.0 14.2 3.3 9.9 14.1 17.4 17.2 12.7 9.2 0.0 18.2 11.3 8.2 3.9 8.0 9.2 13.3 11.9 9.6 1.2 34.5 5.5 6.9 16.0 10.0 10.2 18.0 15.2 28.2 10.0 4.2 12.5 1.7 15.4 13.1 8.2 10.1 12.2 5.7 6.2 11.2 3.6 15.9 16.6 4.4 9.2 19.6 31.7 6.5 6.5 10.1 22.0 22.9 3.2 0.7 12.3 6.8 19.7 15.4 16.9 27.6 43.4 28.6 74.4 5.1 13.4 10.5 14.7 67.2 BCKDK ENSG00000103507 "Branched chain keto acid dehydrogenase kinase" O14874 16 31106107-31112791 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase" "Autism, Autism spectrum disorder, Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 4 "dendritic cells: 95.9;granulocytes: 89.7;monocytes: 115.0" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017995, HPA056067" Supported Supported Mitochondria NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 4: Macrophages - Innate immune response" Mitochondria "HPA017995: AB_1845309, HPA056067: AB_2683024" "unprognostic (1.37e-1)" "unprognostic (2.57e-1)" "unprognostic (6.94e-2)" "unprognostic (5.20e-2)" "unprognostic (5.39e-2)" "unprognostic (3.61e-2)" "unprognostic (1.01e-1)" "unprognostic (5.47e-2)" "unprognostic (1.60e-1)" "unprognostic (1.90e-1)" "unprognostic (1.35e-1)" "unprognostic (3.24e-2)" "unprognostic (2.66e-3)" "unprognostic (4.85e-2)" "unprognostic (3.93e-2)" "unprognostic (1.00e-1)" "unprognostic (4.97e-2)" 32.3 56.4 18.4 19.2 18.6 14.5 29.0 17.4 23.8 25.1 18.0 31.4 16.0 27.7 16.7 29.4 24.8 17.9 78.6 18.8 17.8 43.8 76.4 21.7 15.6 20.6 20.7 27.5 70.5 22.9 16.4 15.3 19.3 29.3 12.5 6.3 47.0 21.8 81.3 45.4 24.1 19.5 17.1 30.2 42.0 17.4 18.5 9.8 22.4 69.7 13.6 30.2 24.6 17.5 47.5 49.1 27.1 41.8 32.8 32.5 31.1 40.4 46.3 57.3 55.9 32.1 29.1 41.5 58.9 47.5 28.0 31.4 19.3 65.6 36.5 34.4 60.1 45.2 32.6 59.5 57.5 23.5 41.9 48.3 26.2 49.2 40.6 52.6 62.4 31.1 23.4 39.4 87.7 75.8 22.9 32.4 23.0 20.5 39.1 45.8 39.6 78.8 44.3 30.1 42.1 38.7 31.3 72.4 24.6 22.9 44.5 24.6 41.1 44.2 26.1 45.8 32.2 44.5 15.7 15.1 50.3 33.7 42.6 58.1 115.0 85.2 17.7 97.6 17.2 22.8 16.5 13.9 95.9 19.0 13.6 16.1 89.7 22.8 71.2 19.3 24.5 53.1 18.4 18.6 17.4 23.8 18.8 17.8 20.6 20.7 19.3 17.1 18.5 17.5 27.2 19.2 18.1 5.9 20.0 18.5 24.6 61.0 22.2 11.6 30.9 27.6 39.1 25.8 28.5 20.2 0.0 55.4 9.0 31.5 80.3 68.6 2.5 14.6 24.3 29.2 19.9 16.4 5.1 78.0 71.1 24.9 25.5 20.0 33.0 35.4 25.4 43.8 93.0 11.8 4.4 22.3 42.7 44.5 50.3 7.8 20.8 53.1 12.4 1.9 79.3 22.6 9.2 4.5 4.5 54.8 48.4 25.6 51.7 30.9 66.9 95.2 19.6 9.8 46.0 18.4 33.2 25.8 14.1 25.7 27.4 69.4 12.1 45.5 26.0 27.0 BCR "ALL, BCR1, CML, D22S11, D22S662, PHL" ENSG00000186716 "BCR activator of RhoGEF and GTPase" P11274 22 23179704-23318037 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "GTPase activation, Guanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 65.7" "Cell type enhanced" "Detected in many" "Hepatic stellate cells: 70.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "K-562: 112.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010421, CAB018545, HPA038337" Approved Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 65: Brain - Ion transport" "Cluster 1: K-562 - Erythropoiesis" "Cluster 44: Endometrium - Transcription" "Plasma membrane, Cytosol" Nucleoplasm "CAB010421: AB_2274682, CAB018545: AB_2063918, HPA038337: AB_10675795" "unprognostic (7.46e-3)" "unprognostic (2.43e-2)" "unprognostic (2.15e-3)" "unprognostic (1.16e-1)" "unprognostic (5.35e-2)" "unprognostic (1.45e-1)" "unprognostic (5.08e-2)" "unprognostic (1.44e-1)" "unprognostic (7.55e-2)" "unprognostic (1.81e-1)" "unprognostic (9.46e-2)" "unprognostic (2.39e-2)" "prognostic favorable (9.15e-10)" "unprognostic (1.47e-1)" "unprognostic (7.10e-2)" "unprognostic (4.10e-2)" "unprognostic (7.43e-2)" 19.4 11.1 34.3 11.0 65.7 34.6 17.4 15.9 30.7 14.3 10.6 11.7 10.0 12.3 16.1 24.5 12.1 9.3 12.2 45.0 22.2 21.1 13.8 18.6 13.7 27.1 26.5 9.4 14.6 20.6 25.0 10.3 24.1 11.8 7.6 7.4 18.3 10.1 5.8 23.5 10.2 8.8 20.9 11.4 16.1 11.0 35.0 14.7 19.7 5.7 10.8 15.3 14.3 14.1 47.6 20.1 30.3 31.2 17.7 12.1 45.6 16.8 15.7 15.2 12.2 35.6 18.7 32.9 30.5 14.4 14.7 47.6 3.6 46.8 4.3 63.3 32.3 28.8 27.7 28.6 22.9 26.9 14.6 10.2 31.1 22.8 19.8 27.0 53.6 23.3 112.5 15.1 7.0 31.3 25.4 21.4 25.8 37.4 19.5 32.9 12.4 21.7 23.7 29.6 27.7 26.3 30.7 26.1 12.6 19.3 16.6 21.7 61.4 9.1 1.0 14.9 14.0 3.4 14.8 11.7 23.4 20.1 14.3 0.0 0.5 0.0 3.1 0.2 1.1 0.6 1.5 1.6 0.4 0.6 1.3 1.7 0.5 1.5 0.5 0.4 0.8 1.4 34.3 65.7 15.9 30.7 45.0 22.2 27.1 26.5 24.1 20.9 35.0 14.1 19.3 9.6 11.5 51.2 4.5 15.4 11.9 18.2 6.2 22.9 17.1 9.9 7.5 17.2 20.9 18.4 22.9 14.0 23.9 17.7 9.8 14.4 5.6 22.1 8.0 27.8 19.9 5.5 24.6 16.6 6.8 7.1 11.7 31.4 10.8 9.9 70.6 22.1 7.2 23.5 20.7 13.9 12.2 9.3 11.1 13.5 8.7 9.2 5.4 18.7 6.6 13.2 15.5 32.2 7.0 27.7 8.1 5.7 10.7 11.8 10.7 18.2 12.5 9.4 0.0 4.0 6.8 2.7 7.3 9.3 15.8 10.8 10.3 10.0 13.7 13.3 BIRC6 BRUCE ENSG00000115760 "Baculoviral IAP repeat containing 6" Q9NR09 2 32357028-32618899 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle, Cell division, Mitosis, Ubl conjugation pathway" "Protease inhibitor, Thiol protease inhibitor, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 272.0;Inhibitory neurons: 291.3;Oligodendrocytes: 361.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "basophil: 9.7" "Lineage enriched" "Detected in all" 5 "granulocytes: 9.7" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA074409, HPA074738" Approved Supported "Golgi apparatus,Vesicles,Mitotic spindle" Yes No "Cluster 18: Basophils - Vesicular transport" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" "Golgi apparatus, Vesicles" "Mitotic spindle" "HPA074409: , HPA074738: AB_2686710" "unprognostic (3.38e-2)" "unprognostic (8.13e-3)" "unprognostic (8.88e-2)" "unprognostic (7.06e-3)" "unprognostic (6.69e-3)" "unprognostic (9.01e-2)" "unprognostic (4.51e-2)" "unprognostic (2.07e-1)" "unprognostic (1.32e-1)" "unprognostic (1.86e-1)" "unprognostic (4.49e-2)" "unprognostic (4.00e-2)" "unprognostic (2.07e-2)" "unprognostic (1.30e-1)" "unprognostic (4.61e-1)" "unprognostic (7.32e-2)" "unprognostic (3.37e-1)" 4.6 4.7 3.1 6.7 9.7 11.3 8.9 13.9 5.7 7.7 6.3 7.6 5.0 6.8 5.2 5.3 6.2 5.8 4.9 4.6 3.7 7.6 8.9 5.4 9.6 6.4 5.5 12.0 14.7 10.9 2.9 6.9 7.3 6.2 7.5 15.5 5.5 5.9 6.1 6.7 5.4 6.1 4.4 8.5 7.1 6.8 5.6 14.7 11.4 8.8 9.7 7.2 3.1 16.3 21.7 17.8 16.1 7.9 14.9 19.1 11.3 10.8 14.1 11.0 11.3 14.2 5.7 23.6 7.3 19.7 13.2 10.1 22.9 15.1 13.9 18.8 10.5 31.2 11.3 10.7 7.9 32.4 11.9 12.4 6.9 18.0 16.2 10.1 17.7 5.4 25.6 10.0 11.9 9.3 15.5 7.5 11.7 9.2 10.5 14.6 26.6 8.2 9.2 23.4 11.7 18.4 18.6 10.8 8.2 12.5 6.4 11.5 28.7 13.0 13.3 9.1 15.3 13.9 20.0 30.6 10.1 15.1 8.7 9.7 0.9 0.6 1.3 0.7 1.8 0.8 1.0 1.2 0.7 1.8 1.1 1.4 1.5 1.6 1.5 1.6 1.0 0.5 3.1 9.7 13.9 5.7 4.6 3.7 6.4 5.5 7.3 4.4 5.6 16.3 53.9 32.1 30.5 239.3 74.8 46.0 28.6 34.7 41.5 60.8 40.0 23.4 45.8 38.6 42.7 36.8 191.8 35.0 93.4 70.1 1.9 26.9 45.9 39.3 58.0 49.8 32.5 34.3 272.0 31.2 22.0 39.7 68.3 63.1 29.9 52.1 45.7 47.5 29.8 69.0 291.3 43.3 26.4 54.7 60.0 17.6 45.4 59.1 23.2 202.4 67.2 34.9 64.9 231.8 361.3 34.3 30.3 59.0 70.9 46.4 48.5 22.6 30.6 88.2 39.5 56.0 49.1 53.7 46.2 49.7 54.8 38.0 72.4 52.8 45.3 44.0 BMP2K "BIKe, DKFZp434K0614" ENSG00000138756 "BMP2 inducible kinase" Q9NSY1 4 78776342-78916365 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 242.9;granulocytes: 129.2;Hofbauer cells: 140.4;Microglial cells: 351.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "fHDF/TERT166: 50.1;HEL: 73.6;HMC-1: 80.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026436, HPA026451, HPA026501" Approved Supported "Nuclear speckles" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 4: Macrophages - Innate immune response" "Nuclear speckles" "HPA026436: AB_10600102, HPA026451: AB_10600228, HPA026501: AB_10601341" "unprognostic (7.96e-2)" "unprognostic (3.68e-1)" "prognostic favorable (1.74e-4)" "unprognostic (9.08e-2)" "unprognostic (1.97e-1)" "unprognostic (9.73e-3)" "unprognostic (1.51e-2)" "unprognostic (1.47e-1)" "unprognostic (2.98e-1)" "unprognostic (7.60e-2)" "unprognostic (1.39e-1)" "unprognostic (9.60e-2)" "unprognostic (9.90e-2)" "unprognostic (9.45e-2)" "unprognostic (1.59e-1)" "unprognostic (1.55e-2)" "unprognostic (3.18e-2)" 6.0 4.2 8.5 13.5 8.2 11.9 7.4 7.3 7.2 6.5 3.8 9.5 5.6 4.4 5.4 7.4 6.0 7.4 8.0 7.2 18.6 4.9 6.7 7.7 16.5 12.1 11.2 3.1 3.5 4.3 0.6 9.2 13.5 3.3 11.9 6.5 3.5 3.5 2.2 9.9 6.9 6.6 10.9 12.2 4.7 10.2 9.8 10.9 7.7 4.5 16.3 7.1 1.4 16.5 11.4 3.2 6.0 7.5 12.0 11.1 4.8 10.8 14.4 10.3 13.7 6.4 6.4 13.2 5.6 50.1 9.9 2.9 6.7 8.5 19.4 3.5 2.3 73.6 5.0 3.5 13.2 15.9 80.6 15.9 11.0 16.4 15.6 7.3 14.4 10.0 19.8 36.5 12.1 2.4 9.5 7.4 2.9 8.8 2.1 13.5 10.3 3.7 13.3 5.2 8.4 5.2 14.2 7.8 10.4 7.9 2.7 10.0 14.7 10.6 4.2 18.4 11.9 7.7 3.2 4.8 9.9 21.4 7.7 0.1 0.5 0.3 0.0 0.2 0.0 0.6 0.0 0.0 0.4 0.6 0.1 0.0 0.9 0.1 0.8 0.3 0.0 0.1 8.5 8.2 7.3 7.2 7.2 18.6 12.1 11.2 13.5 10.9 9.8 16.5 10.7 28.9 16.2 242.9 31.5 25.0 4.3 5.4 10.2 10.9 27.4 15.2 6.5 2.8 7.7 7.3 4.2 5.0 6.1 24.6 0.0 7.5 15.9 18.6 12.7 17.6 6.7 105.4 53.2 8.8 14.2 13.7 6.6 25.0 129.2 32.1 22.1 19.7 140.4 10.1 59.0 48.2 6.1 65.9 68.2 11.1 8.1 65.4 28.4 351.3 34.6 37.0 1.0 49.3 59.1 14.6 43.0 6.8 7.6 6.3 19.9 18.0 12.3 8.4 6.6 22.3 11.7 26.1 11.2 17.1 31.4 3.4 7.6 5.4 24.0 3.2 BMPR1A "ACVRLK3, ALK3, CD292" ENSG00000107779 "Bone morphogenetic protein receptor type 1A" P36894 10 86756601-86932825 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 142.7;Inhibitory neurons: 79.9;Oligodendrocyte precursor cells: 122.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB019398 Approved Approved Cytosol NA NA "Cluster 89: Fibroblasts - ECM organization" "Cluster 3: HMC-1 - Innate immune response" "Cluster 68: Oligodendrocytes - Mixed function" Cytosol "CAB019398: " "unprognostic (1.36e-1)" "unprognostic (2.46e-1)" "unprognostic (3.34e-1)" "unprognostic (9.61e-2)" "unprognostic (1.05e-3)" "unprognostic (9.34e-2)" "prognostic unfavorable (8.93e-4)" "unprognostic (3.64e-1)" "unprognostic (2.38e-2)" "unprognostic (1.53e-1)" "unprognostic (9.24e-2)" "unprognostic (9.42e-2)" "unprognostic (4.32e-2)" "unprognostic (1.80e-1)" "unprognostic (1.47e-1)" "unprognostic (1.01e-2)" "unprognostic (1.07e-1)" 9.1 6.4 4.3 4.5 5.2 0.0 10.3 5.4 5.5 8.1 4.9 9.9 5.4 12.9 11.9 7.8 7.4 9.6 7.8 4.7 6.1 7.0 4.3 7.3 2.9 6.8 5.8 11.6 5.8 9.9 2.6 6.5 6.3 12.5 8.2 4.8 12.1 13.0 7.9 9.3 8.6 12.5 6.2 2.9 7.3 5.2 4.6 2.9 19.1 4.8 3.0 7.9 4.1 6.5 14.6 7.8 27.6 26.8 15.0 10.6 5.5 14.5 18.3 9.4 11.3 11.0 13.1 4.7 6.1 19.2 5.9 15.0 15.8 14.3 14.1 5.5 8.2 5.9 6.9 19.0 10.2 7.4 37.7 10.7 8.5 11.2 9.5 13.9 0.0 8.1 7.6 2.7 12.3 7.0 6.7 7.8 17.6 5.2 4.2 0.0 12.3 0.1 18.9 12.1 3.7 12.8 17.8 8.4 12.6 34.1 15.0 4.1 6.2 7.0 9.8 12.7 13.3 0.3 12.3 5.3 6.5 5.6 6.0 0.3 0.0 0.0 0.3 0.0 0.2 0.3 0.2 0.2 0.0 0.1 0.1 0.2 0.2 0.1 0.0 0.1 0.1 0.0 4.3 5.2 5.4 5.5 4.7 6.1 6.8 5.8 6.3 6.2 4.6 6.5 3.5 35.3 22.4 142.7 3.5 12.1 7.1 9.9 17.6 7.5 10.2 10.2 22.6 18.6 10.5 11.0 20.9 14.1 2.3 10.7 1.9 10.6 0.7 10.7 19.7 4.5 18.0 0.0 63.8 9.5 1.0 20.6 19.4 13.9 15.2 22.9 9.3 7.2 3.4 11.8 79.9 13.9 8.2 4.8 6.1 4.1 33.5 2.3 8.8 34.7 0.8 12.9 2.1 122.2 64.3 8.9 4.9 31.2 3.2 13.7 10.6 5.5 16.5 20.4 6.6 20.3 19.2 2.1 6.6 11.5 9.8 5.1 4.3 11.9 11.1 6.7 BMPR1B "ALK6, CDw293" ENSG00000138696 "Bone morphogenetic protein receptor type 1B" O00238 4 94757955-95158448 "CD markers, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" Chondrogenesis "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 20.1;cervix: 24.7;prostate: 22.4" "Cell type enriched" "Detected in many" 7 "Astrocytes: 480.6" "Cancer enhanced" "Detected in many" "breast cancer: 32.4;prostate cancer: 24.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 22.0;MCF7: 11.1;SH-SY5Y: 18.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 57: Non-specific - Angiogenesis" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 64: Astrocytes - Nervous system maintenance" "unprognostic (2.25e-1)" "unprognostic (1.80e-2)" "unprognostic (1.40e-3)" "prognostic favorable (2.84e-4)" "unprognostic (1.57e-1)" "unprognostic (4.22e-2)" "unprognostic (1.92e-1)" "unprognostic (2.86e-2)" "unprognostic (2.95e-2)" "unprognostic (1.01e-1)" "unprognostic (3.97e-2)" "unprognostic (3.93e-1)" "unprognostic (1.62e-3)" "unprognostic (7.89e-4)" "unprognostic (6.22e-2)" "unprognostic (3.81e-3)" "unprognostic (2.63e-2)" 0.7 4.6 13.4 0.3 15.4 0.1 1.0 13.5 15.0 24.7 2.1 0.9 0.1 4.4 2.4 0.2 12.5 2.6 0.8 12.5 16.0 7.8 0.8 1.7 0.0 19.3 20.1 6.2 1.1 0.1 1.9 0.7 17.5 22.4 0.2 8.1 1.0 14.2 3.0 0.8 0.1 0.6 15.3 0.9 2.4 3.7 15.6 6.4 0.5 1.1 0.0 0.2 0.5 12.1 0.0 22.0 5.6 0.0 2.3 4.8 0.2 0.1 0.0 0.1 0.5 0.0 0.1 0.0 0.2 1.0 0.0 1.3 3.6 8.4 0.1 0.0 4.9 0.0 1.4 0.0 0.6 0.5 0.1 2.7 9.0 2.8 6.2 0.4 0.1 0.0 0.0 0.0 7.1 11.1 0.6 0.1 2.1 0.1 3.2 0.2 3.4 0.1 4.3 0.1 0.2 18.8 0.3 3.2 3.2 0.8 1.7 0.0 0.0 4.0 3.8 0.2 4.3 0.0 0.0 0.0 1.5 0.0 0.5 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.2 0.0 13.4 15.4 13.5 15.0 12.5 16.0 19.3 20.1 17.5 15.3 15.6 12.1 0.0 6.4 0.0 480.6 0.0 2.7 1.3 13.1 1.2 0.4 3.8 1.0 3.4 2.8 33.4 60.7 0.0 0.0 0.0 0.0 1.9 3.0 1.4 28.5 1.4 1.1 18.4 0.0 51.0 0.4 0.3 1.5 0.0 20.8 0.0 38.6 2.9 0.0 0.1 0.0 2.5 0.0 8.2 0.0 1.2 1.4 3.1 0.4 28.4 22.5 0.0 38.5 0.0 10.1 2.8 0.7 0.0 3.8 0.0 28.5 0.0 0.2 15.7 1.6 0.0 1.7 2.9 1.2 10.6 0.4 2.3 0.0 0.5 4.4 0.0 1.6 BMPR2 "BMPR-II, BMPR3, BRK-3, PPH1, T-ALK" ENSG00000204217 "Bone morphogenetic protein receptor type 2" Q13873 2 202376327-202567751 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 202.2;Inhibitory neurons: 190.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017385, HPA049014" Approved Supported "Nucleoplasm,Plasma membrane" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 40: Granulosa cells - Unknown function" "Nucleoplasm, Plasma membrane" "HPA017385: AB_1845397, HPA049014: AB_2680599" "unprognostic (2.17e-1)" "unprognostic (9.00e-2)" "unprognostic (2.35e-1)" "unprognostic (2.73e-1)" "unprognostic (1.67e-1)" "unprognostic (2.55e-1)" "unprognostic (4.30e-2)" "unprognostic (1.11e-1)" "unprognostic (3.18e-2)" "unprognostic (1.10e-2)" "unprognostic (2.13e-2)" "unprognostic (1.97e-1)" "unprognostic (1.29e-2)" "unprognostic (1.21e-3)" "unprognostic (9.20e-2)" "unprognostic (1.18e-1)" "unprognostic (3.40e-1)" 18.5 21.6 8.2 10.9 14.1 2.2 13.2 3.2 16.8 22.6 0.3 13.6 8.5 20.0 11.3 12.4 14.9 17.3 21.5 16.0 14.8 17.4 15.6 29.1 7.2 6.2 7.7 16.8 10.4 17.5 8.5 34.0 10.0 17.1 13.0 26.7 11.0 13.9 10.9 10.9 8.6 24.3 3.9 13.1 11.7 11.3 10.6 9.0 18.2 23.1 9.4 20.6 12.4 5.9 13.3 12.3 12.6 19.7 34.2 31.9 23.8 27.2 28.3 23.6 23.9 10.8 19.6 4.7 30.7 58.2 19.9 24.5 16.8 21.4 41.6 13.8 11.2 14.2 12.6 16.8 22.7 4.0 10.7 24.2 21.5 17.1 22.8 40.6 73.9 5.6 9.3 22.5 33.8 24.8 3.4 3.6 6.9 6.6 11.1 9.1 24.3 7.1 21.3 27.9 12.6 12.7 28.9 17.7 32.7 32.0 13.2 9.5 75.9 48.0 24.4 16.3 16.7 3.1 4.1 1.3 11.3 9.0 13.9 0.1 0.6 0.2 0.9 0.5 0.6 0.3 0.3 0.5 0.6 0.4 0.7 0.3 0.1 0.3 0.9 0.7 1.0 0.3 8.2 14.1 3.2 16.8 16.0 14.8 6.2 7.7 10.0 3.9 10.6 5.9 116.9 105.8 40.3 104.5 15.2 33.4 18.0 34.9 13.6 54.3 29.2 29.7 55.5 15.7 38.8 20.2 81.3 16.9 17.8 25.2 1.9 27.2 2.8 23.1 54.5 152.2 25.1 6.9 202.2 28.1 22.6 47.7 16.8 36.4 23.5 155.1 143.1 19.9 18.7 35.3 190.2 16.3 20.3 24.2 31.7 4.6 33.8 23.5 42.7 170.5 20.2 39.9 16.5 152.8 55.1 46.8 21.1 42.9 9.5 23.9 16.4 12.4 28.0 31.7 65.7 48.8 62.4 33.2 25.0 21.2 35.9 20.0 13.1 0.8 15.5 24.8 BRAF BRAF1 ENSG00000157764 "B-Raf proto-oncogene, serine/threonine kinase" P15056 7 140719327-140924929 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Allosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Cardiomyopathy, Deafness, Disease variant, Ectodermal dysplasia, FDA approved drug targets, Mental retardation, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 252.3;Inhibitory neurons: 242.4;Oligodendrocyte precursor cells: 206.1;Oligodendrocytes: 202.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001328, CAB004552, HPA071048" Approved Approved Vesicles,Cytosol No No "Cluster 15: NK-cells - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 29: U-266 - Adaptive immune response" "Cluster 52: Non-specific - Transcription" Vesicles Cytosol "CAB004552: AB_626760, HPA001328: AB_1078296, HPA071048: AB_2686336" "unprognostic (2.98e-3)" "unprognostic (5.66e-2)" "unprognostic (2.20e-2)" "unprognostic (2.66e-3)" "unprognostic (2.44e-1)" "unprognostic (1.48e-2)" "unprognostic (2.07e-2)" "unprognostic (4.23e-2)" "unprognostic (4.07e-2)" "unprognostic (1.58e-2)" "unprognostic (6.53e-2)" "unprognostic (1.91e-2)" "unprognostic (3.79e-3)" "unprognostic (2.08e-1)" "unprognostic (1.76e-1)" "unprognostic (8.01e-2)" "unprognostic (5.46e-2)" 8.8 5.8 6.3 5.6 7.7 15.9 8.8 12.5 8.7 8.2 5.4 8.6 4.7 8.3 8.3 7.5 8.0 5.8 7.6 8.3 6.7 7.6 6.6 9.9 6.9 4.0 3.6 9.8 8.3 11.5 9.0 7.2 4.6 8.2 5.4 17.0 7.2 5.9 8.6 10.4 6.9 6.0 3.1 6.7 7.8 13.7 5.2 8.7 10.2 8.4 6.4 9.9 8.5 6.7 6.3 5.2 7.7 9.4 9.1 11.8 12.3 6.8 7.5 5.4 7.6 5.7 6.7 10.8 5.0 7.3 8.4 3.4 6.8 5.5 10.0 9.8 5.4 7.1 5.1 5.2 7.6 11.7 6.8 7.9 6.1 6.0 12.0 8.2 6.6 7.7 11.3 19.1 9.8 3.3 15.6 12.0 6.9 6.2 3.1 10.1 6.5 8.9 5.3 11.9 8.9 7.3 7.9 4.9 7.3 7.5 4.5 7.8 9.7 5.9 4.3 12.9 5.5 21.6 12.9 16.7 9.7 11.3 6.6 1.9 1.0 4.1 1.5 0.9 1.0 1.3 1.5 1.2 0.8 1.1 2.6 1.3 2.0 3.5 1.3 1.0 1.5 0.6 6.3 7.7 12.5 8.7 8.3 6.7 4.0 3.6 4.6 3.1 5.2 6.7 43.4 22.4 45.7 151.1 58.4 21.5 24.6 6.0 23.3 29.7 31.2 21.2 19.8 10.0 18.7 25.8 35.5 15.7 73.5 8.8 7.9 14.3 68.6 50.6 37.4 23.4 19.2 14.9 252.3 9.8 12.9 22.0 21.9 69.2 24.7 45.5 9.3 9.6 9.4 25.2 242.4 9.8 8.2 13.6 37.1 36.5 16.4 30.1 16.0 126.5 14.6 11.3 15.5 206.1 202.6 15.4 8.1 10.1 48.7 23.8 8.0 13.4 20.0 33.0 6.6 24.1 24.7 43.8 26.0 14.5 24.0 75.5 41.4 30.9 8.7 33.4 BRAP "BRAP2, IMP, RNF52" ENSG00000089234 "BRCA1 associated protein" Q7Z569 12 111642146-111685956 "Enzymes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 67.2" "Group enriched" "Detected in all" 7 "Early spermatids: 319.6;Late spermatids: 380.1;Spermatocytes: 147.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040357, HPA058820" Approved Supported "Nuclear membrane,Cytosol" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 31: Spermatids - Spermatogenesis" Cytosol "Nuclear membrane" "HPA040357: AB_10967924, HPA058820: AB_2683827" "unprognostic (7.02e-2)" "unprognostic (2.37e-3)" "unprognostic (5.33e-2)" "unprognostic (1.73e-1)" "unprognostic (1.70e-1)" "unprognostic (1.69e-1)" "prognostic unfavorable (7.65e-6)" "unprognostic (2.14e-1)" "unprognostic (9.24e-3)" "unprognostic (2.80e-1)" "unprognostic (1.81e-2)" "unprognostic (1.67e-1)" "unprognostic (1.19e-1)" "unprognostic (3.66e-2)" "unprognostic (1.58e-1)" "unprognostic (3.57e-2)" "unprognostic (8.08e-2)" 9.6 8.8 7.8 7.9 9.2 33.6 9.2 9.8 9.8 8.0 7.3 9.6 9.2 8.8 6.9 9.5 8.5 7.5 9.7 8.1 8.8 8.5 10.0 8.0 10.5 8.8 9.2 9.8 8.2 10.5 6.2 10.6 8.8 8.3 9.2 9.1 8.4 8.3 19.8 12.8 8.8 9.4 8.5 9.0 7.7 67.2 8.4 12.8 9.9 14.0 10.8 9.2 8.1 10.6 14.6 21.1 16.9 19.5 17.7 14.8 28.2 20.0 16.7 22.8 17.5 28.6 10.0 28.0 11.7 19.1 12.9 17.6 23.8 16.4 24.2 18.0 15.4 34.8 12.9 19.4 22.2 30.7 22.5 16.9 22.8 19.7 31.8 19.6 20.0 19.0 36.7 8.9 19.0 18.6 25.7 29.6 22.8 15.4 22.1 23.6 18.4 25.1 15.0 30.3 20.9 15.5 23.5 19.8 19.5 19.3 21.7 19.3 18.8 14.6 13.5 13.3 14.4 22.6 30.9 30.4 13.8 16.8 16.3 22.7 16.8 32.3 17.5 17.5 17.3 16.1 18.5 17.9 15.1 16.5 17.1 17.6 32.7 23.1 14.6 10.9 24.7 16.1 7.8 9.2 9.8 9.8 8.1 8.8 8.8 9.2 8.8 8.5 8.4 10.6 11.6 22.4 11.2 14.7 14.9 11.2 8.9 9.7 12.0 8.9 8.8 7.5 12.7 17.2 10.8 11.0 29.2 13.7 13.7 15.4 5.9 13.5 319.6 11.9 11.6 11.4 9.6 22.9 24.7 7.7 14.9 12.3 15.3 12.4 8.2 13.3 10.4 9.1 10.9 3.3 23.3 12.9 14.2 9.8 11.5 380.1 13.4 11.7 3.6 10.3 19.7 8.6 17.5 13.0 23.3 14.5 12.7 13.5 15.0 13.4 13.5 14.6 13.8 11.8 6.6 11.6 15.1 147.8 38.6 15.4 12.6 22.4 13.5 10.2 11.0 14.5 BRPF1 BR140 ENSG00000156983 "Bromodomain and PHD finger containing 1" P55201 3 9731729-9748015 "Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, Chromatin regulator, DNA-binding" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "BEWO: 82.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003359 Enhanced Approved "Plasma membrane,Cytosol" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 28: BEWO - Transcription regulation" "Cluster 10: Non-specific - Unknown function" "Plasma membrane, Cytosol" "HPA003359: AB_1078217" "unprognostic (4.18e-2)" "unprognostic (2.21e-2)" "unprognostic (6.47e-2)" "unprognostic (9.10e-2)" "unprognostic (3.42e-1)" "unprognostic (2.33e-2)" "prognostic unfavorable (3.20e-5)" "unprognostic (3.00e-1)" "unprognostic (3.72e-1)" "unprognostic (3.26e-3)" "unprognostic (4.27e-2)" "prognostic unfavorable (5.28e-4)" "unprognostic (1.51e-3)" "unprognostic (4.86e-2)" "unprognostic (3.55e-1)" "unprognostic (6.87e-2)" "unprognostic (9.67e-3)" 8.0 7.1 4.7 6.9 6.9 23.5 7.7 9.9 7.4 8.2 3.8 8.3 4.8 9.5 4.4 8.6 8.8 5.5 7.3 6.7 3.8 6.2 5.5 7.9 8.9 4.7 4.2 9.3 7.3 7.7 6.7 6.5 4.3 7.5 4.0 4.0 9.1 5.0 9.5 10.9 8.3 5.4 3.1 10.5 7.5 14.4 5.2 11.9 9.0 6.8 7.6 7.9 7.8 5.5 9.9 17.2 12.5 8.2 8.9 8.6 82.4 12.6 7.5 14.3 10.2 12.1 8.3 18.6 6.0 11.6 13.5 8.2 15.3 12.0 9.0 20.1 17.9 21.4 33.8 9.8 11.4 30.6 20.0 8.5 9.8 19.8 13.1 7.2 10.8 17.5 25.2 15.9 8.3 24.3 19.8 25.7 20.6 6.7 15.9 28.7 10.6 12.3 6.7 14.5 8.9 15.2 12.7 9.0 10.1 8.2 9.8 31.4 14.1 15.9 13.6 14.5 24.0 13.4 18.1 31.5 13.1 25.9 15.1 1.0 0.9 1.4 1.3 0.8 2.0 0.6 0.9 1.2 0.8 0.5 1.1 1.3 0.8 4.2 0.7 1.9 0.7 0.8 4.7 6.9 9.9 7.4 6.7 3.8 4.7 4.2 4.3 3.1 5.2 5.5 7.9 16.0 10.0 2.6 6.8 14.1 5.1 3.9 8.0 4.6 9.2 7.0 3.7 2.8 6.2 7.3 6.2 4.2 13.0 9.4 0.0 4.1 3.9 4.2 6.9 9.7 10.2 9.7 3.4 5.5 5.5 5.8 7.7 7.0 8.8 7.3 11.0 3.5 6.4 8.4 2.4 5.0 2.0 5.6 9.2 1.2 6.5 6.9 1.8 2.8 6.3 5.2 5.2 4.0 2.9 6.1 3.1 6.0 7.9 5.1 4.9 2.1 4.3 5.1 6.6 11.3 7.7 16.6 13.9 9.9 18.5 3.7 10.8 5.6 6.1 6.8 BRSK1 KIAA1811 ENSG00000160469 "BR serine/threonine kinase 1" Q8TDC3 19 55282072-55312562 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell cycle, DNA damage, Neurogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 141.8;pituitary gland: 53.0" "Cell type enhanced" "Detected in many" "Bipolar cells: 34.8;Excitatory neurons: 30.1;Horizontal cells: 38.7;Inhibitory neurons: 27.6;Oligodendrocyte precursor cells: 17.1;Oligodendrocytes: 29.4;Proximal enterocytes: 23.6" "Cancer enhanced" "Detected in all" "glioma: 12.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "SCLC-21H: 56.4;SH-SY5Y: 51.8;WM-115: 46.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021212, HPA061719" Enhanced Supported "Nucleoplasm,Cell Junctions" NA NA "Cluster 65: Brain - Ion transport" "Cluster 17: WM-115 - Nervous system development" "Cluster 45: Enterocytes - Digestion" Nucleoplasm "Cell Junctions" "HPA021212: AB_1845455, HPA061719: AB_2684593" "unprognostic (1.42e-3)" "unprognostic (2.92e-2)" "unprognostic (1.20e-1)" "unprognostic (6.69e-3)" "unprognostic (2.71e-1)" "unprognostic (4.21e-2)" "unprognostic (3.06e-6)" "unprognostic (4.24e-1)" "unprognostic (2.06e-2)" "unprognostic (3.04e-1)" "prognostic favorable (1.02e-4)" "unprognostic (3.00e-1)" "prognostic unfavorable (7.98e-6)" "unprognostic (1.16e-1)" "unprognostic (6.61e-3)" "unprognostic (1.34e-1)" "unprognostic (2.09e-1)" 1.5 12.0 75.0 3.7 90.1 0.5 2.6 47.5 141.8 5.9 0.0 11.8 3.8 8.3 4.0 3.2 5.4 4.4 12.8 103.2 66.1 2.4 0.7 1.9 2.7 70.4 54.8 5.5 2.8 16.9 53.0 1.1 66.8 8.3 1.6 20.4 2.3 5.0 0.7 1.5 4.7 5.6 32.9 1.8 4.9 11.4 74.1 2.3 3.1 1.4 1.4 6.3 4.6 105.5 0.8 2.8 33.2 17.6 0.1 1.4 0.3 5.9 7.7 7.1 10.3 13.1 5.9 7.0 3.7 6.2 6.6 0.3 7.0 0.3 6.6 33.3 28.0 4.6 4.0 1.4 7.0 1.5 12.8 4.6 0.6 7.3 0.0 27.4 0.3 17.9 6.6 40.8 6.5 1.9 9.0 1.7 24.9 0.7 2.3 20.4 8.5 1.1 0.5 0.0 56.4 51.8 0.1 1.0 12.8 9.2 2.9 3.8 0.0 13.7 15.2 7.7 10.8 37.9 28.0 16.6 13.8 3.1 46.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 75.0 90.1 47.5 141.8 103.2 66.1 70.4 54.8 66.8 32.9 74.1 105.5 0.3 0.0 1.3 9.4 5.2 0.1 1.0 0.1 1.2 34.8 0.9 2.2 1.2 0.0 0.6 1.8 2.1 0.0 1.2 10.4 0.0 0.4 1.2 0.3 3.8 0.9 3.5 0.0 30.1 0.0 0.0 1.2 0.5 0.3 0.0 2.3 0.0 0.0 1.6 38.7 27.6 1.6 0.0 6.6 0.4 0.3 0.6 1.0 0.0 1.0 2.3 4.1 3.1 17.1 29.4 0.5 0.1 4.9 9.8 1.0 23.6 0.9 0.2 10.1 0.0 0.6 2.1 3.9 7.0 0.0 0.0 0.0 1.1 2.8 1.9 0.2 BRSK2 "C11orf7, PEN11B, STK29" ENSG00000174672 "BR serine/threonine kinase 2" Q8IWQ3 11 1389899-1462689 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Cell cycle, Cell division, Exocytosis, Mitosis, Neurogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 37.8;pancreas: 104.2" "Cell type enhanced" "Detected in some" "Astrocytes: 22.9;Bipolar cells: 87.9;Cone photoreceptor cells: 35.5;Excitatory neurons: 35.5;Horizontal cells: 69.0;Inhibitory neurons: 23.5;Rod photoreceptor cells: 28.6" "Cancer enhanced" "Detected in many" "glioma: 3.7" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 15.8;AN3-CA: 17.3;CACO-2: 14.4;HAP1: 13.3;NTERA-2: 27.2;SCLC-21H: 62.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA073690 Approved "Golgi apparatus" NA NA "Cluster 22: Non-specific - Unknown function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 56: Bipolar cells - Visual perception" "Golgi apparatus" "HPA073690: " "unprognostic (5.47e-2)" "unprognostic (4.11e-2)" "unprognostic (1.26e-1)" "unprognostic (2.85e-2)" "unprognostic (1.18e-1)" "unprognostic (1.40e-2)" "unprognostic (1.05e-2)" "unprognostic (3.63e-1)" "unprognostic (6.42e-2)" "unprognostic (3.86e-2)" "unprognostic (2.22e-2)" "unprognostic (2.31e-1)" "unprognostic (3.17e-7)" "unprognostic (3.24e-2)" "unprognostic (1.57e-1)" "unprognostic (1.49e-3)" "unprognostic (1.86e-1)" 1.1 2.4 11.5 0.2 16.0 0.1 0.7 29.2 37.8 2.1 0.0 2.8 0.5 1.0 0.0 0.8 2.0 0.7 1.0 20.5 2.1 0.5 0.2 0.4 0.1 7.9 3.6 0.9 104.2 2.2 15.6 0.6 8.6 1.4 0.1 17.4 0.4 0.2 0.4 0.3 1.5 0.1 0.5 0.6 1.9 9.0 5.0 0.1 1.0 0.2 0.0 0.8 1.1 17.6 0.1 7.2 15.8 17.3 0.3 0.5 0.0 0.2 0.2 1.3 0.5 14.4 0.9 0.0 2.4 0.2 0.2 0.0 13.3 0.1 1.0 1.7 6.2 0.0 0.0 0.2 0.7 0.0 0.6 0.2 0.0 0.0 1.6 0.3 0.0 0.5 0.2 0.1 0.3 1.7 0.0 0.0 27.2 5.1 2.2 0.0 0.0 0.0 0.2 0.2 62.0 9.0 3.3 0.2 4.7 0.3 0.3 0.8 0.3 1.4 0.1 0.1 0.0 0.4 0.0 0.0 0.2 0.1 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.5 16.0 29.2 37.8 20.5 2.1 7.9 3.6 8.6 0.5 5.0 17.6 0.4 0.0 0.0 22.9 0.1 0.3 0.1 0.0 0.0 87.9 0.1 0.1 2.1 0.0 0.0 0.0 35.5 0.0 0.2 0.1 0.0 0.1 0.5 0.2 0.4 0.6 0.0 0.0 35.5 1.0 0.0 0.4 0.0 0.4 0.0 0.1 0.0 0.0 0.2 69.0 23.5 0.2 0.0 0.0 0.0 0.7 0.9 0.1 0.0 6.5 0.0 20.7 0.0 20.1 20.6 0.3 0.0 1.2 0.0 0.2 0.0 0.1 0.0 28.6 6.6 0.9 6.0 0.9 1.7 0.1 0.0 0.0 0.6 0.1 0.1 0.0 BUB1 "BUB1A, BUB1L, hBUB1" ENSG00000169679 "BUB1 mitotic checkpoint serine/threonine kinase" O43683 2 110637528-110678063 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle, Cell division, Chromosome partition, Host-virus interaction, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "bone marrow: 11.9;lymphoid tissue: 27.5;testis: 30.3" "Cell type enhanced" "Detected in many" "Erythroid cells: 24.8;Granulosa cells: 66.1;Plasma cells: 35.2;Spermatocytes: 85.6;Spermatogonia: 20.0" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HEL: 221.5" "Region enhanced" "Detected in single" "white matter: 1.7" "Not detected" "Not detected" HPA006123 Supported Nucleoplasm,Cytosol NA Yes "Cluster 46: Basophils - DNA binding" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 36: HEL - Hemostasis" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm Cytosol "HPA006123: AB_1845498" "unprognostic (7.74e-2)" "unprognostic (3.45e-2)" "unprognostic (9.72e-3)" "prognostic unfavorable (3.65e-4)" "unprognostic (1.61e-1)" "unprognostic (5.62e-3)" "prognostic unfavorable (1.03e-5)" "prognostic unfavorable (3.94e-4)" "unprognostic (1.26e-3)" "unprognostic (1.15e-1)" "prognostic unfavorable (2.37e-5)" "unprognostic (1.76e-1)" "unprognostic (0.00e+0)" "unprognostic (2.45e-2)" "unprognostic (3.64e-1)" "unprognostic (5.01e-2)" "unprognostic (1.28e-1)" 0.5 0.4 0.1 8.4 0.3 11.9 1.2 0.1 0.1 0.9 0.0 4.3 4.0 1.0 3.5 4.7 0.5 0.9 0.6 0.1 0.1 0.3 0.6 1.2 15.9 0.1 0.6 0.4 0.2 0.7 0.0 3.2 0.3 0.3 5.7 0.1 0.9 0.1 0.1 2.7 3.5 2.2 0.0 5.6 1.9 30.3 0.4 27.5 0.4 0.2 17.0 2.4 1.6 0.3 96.0 29.4 68.5 46.8 3.8 5.3 38.8 50.9 32.9 85.6 62.3 58.3 55.0 64.7 30.9 30.1 80.1 43.2 93.9 35.0 105.7 51.4 45.6 221.5 26.2 50.6 0.8 63.5 57.0 1.7 2.8 65.2 33.1 12.7 49.8 73.2 96.8 126.5 76.8 33.7 126.3 39.0 71.2 39.4 55.3 69.3 64.2 102.7 18.3 27.0 48.3 21.4 34.2 31.4 27.2 44.1 24.0 60.6 19.1 39.7 57.5 28.8 69.0 67.3 65.5 75.4 24.2 48.6 69.8 1.1 0.0 0.2 0.2 0.0 0.3 0.5 0.9 0.5 0.1 0.5 0.6 0.4 0.0 0.5 0.0 0.9 1.5 0.3 0.1 0.3 0.1 0.1 0.1 0.1 0.1 0.6 0.3 0.0 0.4 0.3 0.2 0.0 1.5 0.0 5.5 0.5 0.5 2.0 0.6 0.0 0.9 0.8 1.1 0.0 1.6 0.0 0.0 5.8 2.5 2.4 0.0 0.3 13.5 4.5 1.5 1.1 0.0 24.8 0.2 0.0 9.8 2.2 2.0 2.2 0.0 66.1 1.8 0.3 8.1 0.0 0.2 3.1 4.1 1.6 1.4 7.5 0.3 2.0 0.0 0.0 0.6 0.0 0.0 0.5 1.0 0.1 0.0 0.4 35.2 0.5 0.3 0.1 1.8 0.0 6.6 0.2 3.7 85.6 20.0 4.0 0.4 0.7 2.9 0.5 5.9 0.9 BUB1B "Bub1A, BUBR1, MAD3L, SSK1" ENSG00000156970 "BUB1 mitotic checkpoint serine/threonine kinase B" O60566 15 40161023-40221123 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 17.8;lymphoid tissue: 35.7;testis: 22.2" "Cell type enhanced" "Detected in many" "Erythroid cells: 23.5;Spermatocytes: 79.2;Spermatogonia: 26.8" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "naive B-cell: 1.1" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in many" HPA008419 Supported Cytosol Yes Yes "Cluster 24: B-cells - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Cytosol "HPA008419: AB_1078308" "unprognostic (4.40e-2)" "unprognostic (2.23e-1)" "unprognostic (4.65e-2)" "unprognostic (2.44e-3)" "unprognostic (9.66e-2)" "unprognostic (3.52e-2)" "prognostic unfavorable (7.43e-6)" "prognostic unfavorable (3.56e-4)" "unprognostic (3.69e-3)" "unprognostic (2.32e-1)" "prognostic unfavorable (1.79e-4)" "unprognostic (1.76e-2)" "unprognostic (0.00e+0)" "unprognostic (3.75e-2)" "unprognostic (4.66e-2)" "unprognostic (2.20e-1)" "unprognostic (3.94e-2)" 0.4 0.5 0.1 6.7 0.1 17.8 1.6 0.3 0.2 1.0 7.7 4.6 4.7 1.2 0.3 5.2 0.6 0.6 0.3 0.3 0.1 0.3 0.4 1.0 12.6 0.0 0.1 0.2 0.2 0.2 0.1 3.4 0.1 0.4 6.0 0.1 0.9 0.2 0.0 3.5 4.1 2.1 0.0 3.1 2.4 22.2 0.2 35.7 0.5 0.0 15.0 1.5 1.7 0.0 66.5 32.8 103.0 41.5 2.5 7.1 33.2 60.9 34.2 64.6 55.7 48.1 25.0 59.7 33.5 22.7 59.0 72.6 98.8 33.2 70.5 51.8 52.1 86.4 83.6 45.5 0.2 79.0 45.7 1.6 2.0 39.2 37.1 12.9 47.7 66.5 76.4 61.7 65.6 22.5 62.5 48.9 70.2 55.6 36.8 66.5 83.7 45.2 19.9 33.1 67.1 40.8 38.0 35.9 13.3 45.1 41.9 40.9 27.6 49.3 51.8 49.2 55.5 32.1 58.2 95.6 26.3 87.8 65.4 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.2 0.1 0.2 1.1 0.0 0.1 0.0 0.1 0.0 0.8 0.0 0.1 0.1 0.1 0.3 0.2 0.3 0.1 0.0 0.1 0.1 0.0 0.2 0.0 0.1 3.2 1.1 0.3 1.8 0.8 0.3 1.0 1.8 0.7 0.9 2.0 0.8 0.0 1.9 0.0 0.0 5.4 0.6 1.8 0.0 0.4 3.0 0.9 1.4 1.0 0.0 23.5 0.7 0.0 6.7 2.4 5.6 2.1 0.0 12.9 1.1 0.3 5.2 0.0 0.7 2.5 0.0 1.9 1.7 3.3 1.5 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.6 1.5 0.4 12.6 0.3 0.3 0.1 0.2 0.2 6.6 0.2 1.7 79.2 26.8 6.9 0.3 0.8 1.8 0.8 5.4 0.6 CALM1 "CALML2, CAMI, DD132, PHKD" ENSG00000198668 "Calmodulin 1" P0DP23 14 90396502-90408268 "Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Host-virus interaction" "Disease variant, FDA approved drug targets, Long QT syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB018558, HPA044999" Supported Supported Cytosol NA NA 75000000 "Cluster 44: Non-specific - Transcription" "Cluster 10: Brain - Neuronal signaling" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 7: Non-specific - Mitochondria" Cytosol "CAB018558: AB_2069454, HPA044999: AB_2679177" "unprognostic (5.35e-3)" "unprognostic (3.96e-1)" "unprognostic (4.99e-3)" "unprognostic (2.91e-2)" "unprognostic (1.07e-1)" "unprognostic (2.87e-2)" "unprognostic (1.99e-3)" "unprognostic (1.52e-1)" "unprognostic (6.44e-2)" "unprognostic (1.16e-3)" "prognostic favorable (5.62e-4)" "unprognostic (2.77e-1)" "prognostic favorable (6.49e-4)" "unprognostic (2.66e-1)" "unprognostic (2.68e-1)" "unprognostic (1.11e-2)" "prognostic unfavorable (2.38e-5)" 264.2 143.5 429.9 152.3 537.5 349.1 123.1 442.8 839.7 134.2 259.8 332.9 289.6 105.1 209.7 304.6 251.4 153.8 287.0 635.9 371.6 326.3 210.9 209.1 165.7 466.2 374.6 104.4 121.7 225.5 143.9 207.4 447.5 169.5 312.2 241.6 188.0 215.3 588.9 104.0 279.2 227.2 328.7 166.6 202.2 123.6 443.5 146.5 118.0 185.6 210.5 191.6 125.2 527.2 189.3 256.3 308.0 115.7 332.2 286.5 256.9 347.4 295.3 260.0 283.2 278.1 320.9 200.8 171.1 413.0 123.4 309.4 194.6 490.1 431.0 398.3 119.7 212.4 211.0 264.1 185.9 327.6 167.2 188.0 232.7 261.6 93.1 173.6 592.9 140.3 101.3 270.0 353.9 653.7 112.4 316.2 178.4 521.1 351.6 216.9 264.9 134.4 215.3 574.5 621.2 259.1 292.3 507.7 195.5 254.0 335.6 112.0 363.1 212.9 137.7 224.8 289.0 149.5 371.0 222.2 335.9 267.6 301.5 1289.6 356.8 826.7 1005.3 420.4 1230.3 496.8 1039.1 1079.6 483.1 400.2 745.7 882.7 513.3 1036.9 647.3 453.3 1168.3 1477.9 429.9 537.5 442.8 839.7 635.9 371.6 466.2 374.6 447.5 328.7 443.5 527.2 1812.3 387.8 374.4 119.8 573.2 567.1 572.2 604.2 543.5 1729.1 343.7 514.8 867.5 346.0 523.1 399.1 123.0 427.7 1471.8 828.8 459.7 550.8 154.9 1026.1 249.0 996.0 599.8 143.5 367.6 444.7 984.2 521.4 317.0 377.6 490.3 148.5 652.5 333.7 795.1 604.0 258.9 513.9 730.4 286.5 837.4 101.5 210.6 639.9 627.9 131.2 856.3 1061.8 1100.9 108.0 188.9 534.2 615.8 500.2 591.8 287.7 1637.2 1430.5 1618.4 321.1 315.5 387.5 901.6 128.8 199.8 553.8 580.4 1147.6 1139.3 247.8 666.6 458.5 CALM2 "CAMII, PHKD" ENSG00000143933 "Calmodulin 2" P0DP24 2 47160083-47176921 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Disease variant, Long QT syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007790, HPA044999" Approved NA Yes "Cluster 45: Eosinophils - Innate immune response" "Cluster 45: Intestine - Brush border" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "CAB007790: AB_562257, HPA044999: AB_2679177" "prognostic unfavorable (5.05e-4)" "unprognostic (2.94e-2)" "unprognostic (1.42e-1)" "prognostic unfavorable (4.84e-4)" "unprognostic (9.21e-2)" "unprognostic (2.04e-3)" "prognostic unfavorable (8.35e-5)" "unprognostic (1.63e-2)" "unprognostic (4.67e-3)" "unprognostic (1.79e-2)" "unprognostic (1.97e-2)" "unprognostic (1.24e-2)" "unprognostic (1.14e-1)" "unprognostic (1.18e-2)" "unprognostic (2.29e-2)" "prognostic favorable (1.94e-5)" "unprognostic (1.24e-1)" 509.3 652.1 1177.9 334.4 1219.1 240.3 686.1 1229.7 1745.6 420.1 988.8 683.9 549.8 507.6 551.1 366.8 526.5 390.8 443.0 1229.0 1219.0 445.7 493.1 505.6 427.9 1209.1 1192.8 416.1 213.3 332.3 441.3 468.9 1227.6 449.1 706.0 574.8 490.8 561.5 262.9 304.2 621.2 634.7 1209.4 643.0 390.4 508.8 1257.9 571.0 443.3 258.1 467.2 459.0 340.2 1411.8 2459.6 905.8 1062.2 459.7 579.4 679.5 655.8 2177.2 1504.3 1437.1 1240.1 958.1 923.2 956.1 979.5 1753.2 1030.4 624.7 878.3 855.6 1907.0 729.3 438.6 821.6 526.6 1409.6 779.5 996.3 686.2 381.2 825.0 1265.3 1347.0 1230.4 977.3 312.8 812.1 854.7 3485.7 635.9 1270.2 984.3 801.3 2961.6 488.6 314.3 1142.9 1021.9 1631.0 441.0 756.8 2016.6 726.5 756.0 1120.1 1144.3 573.7 556.7 1084.8 1060.8 1135.8 627.0 1703.6 648.8 529.1 1038.2 718.8 711.3 1357.7 944.7 447.6 776.8 139.7 844.1 177.2 285.6 203.4 213.2 354.0 182.1 173.7 201.6 417.9 277.1 761.4 445.6 227.4 496.5 1177.9 1219.1 1229.7 1745.6 1229.0 1219.0 1209.1 1192.8 1227.6 1209.4 1257.9 1411.8 597.4 1387.8 613.5 195.2 570.7 1780.5 1101.0 2616.3 524.8 654.3 844.4 572.9 639.6 581.9 1751.8 759.6 98.0 931.4 649.8 906.5 2304.8 1977.0 312.7 889.1 363.8 652.0 597.1 697.1 317.5 683.4 627.9 943.6 354.8 452.5 665.4 484.5 280.6 536.6 1267.1 341.6 179.0 1020.1 3352.8 867.1 1858.2 287.0 1055.3 911.0 1771.6 143.4 1167.2 2063.1 350.1 129.7 339.8 2584.9 1114.4 863.6 309.7 1016.8 1231.6 1020.2 3245.3 334.2 907.2 671.6 1882.0 2193.5 714.3 503.0 1663.1 255.3 669.1 615.4 771.1 1062.2 CALM3 PHKD ENSG00000160014 "Calmodulin 3" P0DP25 19 46601074-46610782 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Disease variant, Long QT syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 868.1" "Cell type enhanced" "Detected in all" "Early spermatids: 1863.5;Late spermatids: 2674.8;Spermatocytes: 875.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044999 Approved NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 10: Brain - Neuronal signaling" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 34: Spermatids - Unknown function" "HPA044999: AB_2679177" "unprognostic (3.39e-1)" "unprognostic (1.30e-1)" "unprognostic (5.81e-2)" "unprognostic (1.13e-1)" "unprognostic (9.81e-2)" "unprognostic (1.29e-2)" "unprognostic (2.39e-2)" "prognostic unfavorable (2.07e-4)" "unprognostic (4.01e-3)" "unprognostic (5.28e-2)" "unprognostic (1.67e-1)" "unprognostic (5.34e-2)" "unprognostic (2.72e-2)" "unprognostic (2.59e-1)" "unprognostic (1.07e-1)" "prognostic favorable (9.10e-4)" "unprognostic (2.72e-1)" 136.3 186.9 309.9 153.9 428.0 194.4 113.2 19.8 868.1 187.9 0.0 178.8 203.6 175.4 97.6 118.4 148.8 135.9 272.4 498.5 183.4 177.3 137.2 125.7 179.4 240.2 77.0 189.0 116.3 110.3 138.6 133.3 199.8 143.6 158.2 152.0 73.1 157.7 340.0 85.6 228.9 166.8 25.8 122.2 143.4 469.0 184.3 270.8 118.1 253.0 172.2 173.2 150.8 505.1 392.6 437.1 493.9 174.6 256.1 338.9 119.5 405.8 333.6 358.0 473.1 374.8 342.5 322.3 185.2 599.0 249.7 297.6 496.9 322.0 453.5 498.0 387.6 433.7 201.8 404.5 139.0 324.5 596.5 334.6 106.9 281.1 218.3 274.2 450.6 353.4 335.7 447.0 345.3 250.1 354.3 818.1 251.6 575.7 192.3 644.7 254.5 121.9 341.4 463.3 253.6 279.7 304.6 194.1 123.7 484.3 227.9 364.7 329.2 197.6 366.2 150.5 298.5 370.2 280.6 262.1 197.9 279.5 255.7 190.6 158.2 262.4 67.2 193.9 61.0 74.7 95.5 90.0 93.5 68.6 112.0 71.6 433.7 103.6 194.3 55.1 195.6 150.7 309.9 428.0 19.8 868.1 498.5 183.4 240.2 77.0 199.8 25.8 184.3 505.1 77.6 41.7 56.8 23.8 101.8 57.2 82.8 82.0 32.5 136.2 82.4 86.1 177.5 87.2 59.9 69.9 12.5 202.9 120.0 301.1 260.3 265.0 1863.5 101.6 76.4 88.7 122.4 318.4 114.1 221.5 545.1 112.3 89.2 82.4 106.0 130.6 125.7 106.4 760.3 89.2 89.4 178.2 59.0 307.8 112.7 2674.8 106.9 349.8 92.5 32.8 525.0 184.2 225.6 23.1 30.2 205.1 273.5 122.6 143.3 67.6 457.2 365.6 85.4 88.2 92.1 47.8 130.9 875.3 157.4 64.6 65.9 184.8 161.1 192.7 208.8 111.9 CAMK1 "CaMKI, CaMKI-alpha" ENSG00000134072 "Calcium/calmodulin dependent protein kinase I" Q14012 3 9757347-9769992 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell cycle, Differentiation, Neurogenesis" "Allosteric enzyme, Calmodulin-binding, Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 58.3;Hofbauer cells: 76.2;Macrophages: 71.2;Sertoli cells: 59.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 7 "eosinophil: 280.5" "Lineage enriched" "Detected in many" 7 "granulocytes: 280.5" "Cell line enriched" "Detected in many" 4 "HMC-1: 403.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB031904, HPA051409" Approved Approved Cytosol NA NA 110000 "Cluster 52: Eosinophils - Transcription" "Cluster 35: Non-specific - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 4: Macrophages - Innate immune response" Cytosol "CAB031904: AB_630964, HPA051409: AB_2681473" "unprognostic (4.43e-2)" "unprognostic (3.05e-1)" "unprognostic (1.68e-1)" "unprognostic (1.29e-1)" "unprognostic (1.11e-1)" "unprognostic (3.06e-2)" "prognostic unfavorable (7.52e-4)" "unprognostic (5.53e-2)" "unprognostic (3.32e-1)" "unprognostic (9.74e-2)" "unprognostic (1.37e-3)" "unprognostic (2.17e-1)" "unprognostic (1.14e-3)" "unprognostic (7.76e-2)" "unprognostic (1.72e-1)" "unprognostic (3.67e-2)" "unprognostic (3.01e-1)" 52.4 99.7 50.1 17.2 48.9 5.1 37.2 39.9 61.0 27.0 31.8 33.6 9.2 31.8 13.7 8.0 37.0 11.1 20.5 61.2 46.3 24.9 36.4 23.9 11.1 37.8 41.7 41.2 8.4 14.4 21.6 6.7 38.8 31.1 10.6 5.9 9.8 19.7 7.1 7.9 16.5 26.0 36.8 16.7 21.7 29.8 46.9 4.3 19.5 7.8 15.0 28.4 18.3 46.1 0.5 16.4 12.6 0.0 64.7 24.3 32.6 38.4 21.1 43.1 40.4 24.1 3.0 1.1 9.0 26.0 6.2 2.7 0.0 5.0 27.0 0.4 95.4 53.5 32.1 34.1 35.9 4.5 403.3 25.3 4.1 60.6 6.7 35.4 36.8 0.9 7.2 1.2 16.3 10.3 0.3 38.8 9.0 0.4 25.7 0.3 0.4 1.1 25.9 2.8 4.2 16.7 6.6 0.7 4.0 5.3 4.1 67.2 19.6 19.8 24.4 28.0 48.7 0.4 0.3 1.0 41.5 14.7 3.0 17.8 21.3 280.5 0.3 42.2 0.1 0.1 0.4 0.2 14.1 0.2 0.3 0.1 1.0 3.6 43.0 0.4 2.0 4.7 50.1 48.9 39.9 61.0 61.2 46.3 37.8 41.7 38.8 36.8 46.9 46.1 58.3 0.0 3.1 17.9 2.8 5.0 19.2 3.4 5.7 9.9 5.2 4.6 0.1 12.8 2.1 11.0 2.1 0.4 3.0 2.6 9.8 14.4 1.8 1.8 14.9 22.8 6.0 4.8 25.6 4.0 1.2 23.3 5.6 3.1 30.5 16.7 30.4 23.5 76.2 0.0 14.5 2.3 0.0 46.4 40.2 7.2 36.1 71.2 5.4 8.4 36.7 39.4 3.1 6.6 2.7 5.5 2.9 45.1 0.2 17.5 3.6 47.4 1.3 7.7 59.2 12.2 42.7 1.5 3.7 1.5 3.8 0.8 7.1 6.6 7.6 11.0 CAMK1D CKLiK ENSG00000183049 "Calcium/calmodulin dependent protein kinase ID" Q8IU85 10 12349547-12835545 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Inflammatory response, Neurogenesis" "Allosteric enzyme, Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "retina: 57.9" "Cell type enhanced" "Detected in many" "Bipolar cells: 167.4;Cone photoreceptor cells: 392.0;Excitatory neurons: 416.9;Inhibitory neurons: 233.6;Microglial cells: 168.6;Rod photoreceptor cells: 214.2" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in many" 5 "amygdala: 14.9;basal ganglia: 16.7;cerebral cortex: 35.6;hippocampal formation: 29.6;white matter: 14.5" "Immune cell enhanced" "Detected in all" "eosinophil: 75.1" "Lineage enriched" "Detected in all" 5 "granulocytes: 75.1" "Cell line enhanced" "Detected in many" "HDLM-2: 113.8;U-266/70: 50.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007266 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 58: Brain - Synaptic function" "Cluster 44: HDLM-2 - Immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoplasm, Cytosol" "HPA007266: AB_1078389" "unprognostic (1.06e-1)" "unprognostic (2.19e-2)" "unprognostic (2.77e-1)" "unprognostic (3.65e-3)" "unprognostic (4.23e-1)" "unprognostic (2.32e-2)" "unprognostic (6.90e-3)" "prognostic favorable (1.67e-4)" "unprognostic (1.06e-1)" "unprognostic (1.49e-2)" "unprognostic (2.95e-1)" "unprognostic (7.40e-2)" "unprognostic (1.35e-2)" "unprognostic (6.55e-2)" "unprognostic (1.65e-1)" "unprognostic (4.66e-2)" "unprognostic (2.56e-3)" 6.6 4.8 14.9 8.4 16.7 6.8 4.3 4.5 35.6 7.4 1.1 11.4 3.5 3.2 2.8 8.6 3.8 5.9 14.6 29.6 0.6 2.6 8.2 7.5 9.6 3.7 0.1 2.7 16.9 0.9 2.8 2.9 0.0 4.7 12.4 57.9 4.3 7.0 1.5 18.5 6.3 5.2 0.7 10.9 3.1 6.1 1.3 23.5 13.0 2.3 12.6 7.1 9.2 14.5 0.3 6.1 6.8 0.3 4.0 1.4 0.4 0.9 2.2 1.4 2.0 8.6 4.8 3.4 0.7 0.6 3.4 3.2 8.4 1.2 1.1 113.8 4.1 13.6 19.4 0.4 1.1 0.3 11.8 0.2 5.2 2.7 0.2 14.6 0.8 7.2 0.4 0.4 1.7 7.2 26.9 5.6 4.6 0.0 2.7 20.2 3.7 6.4 0.2 6.5 10.4 4.8 13.2 4.9 0.0 0.9 3.4 3.3 0.3 5.6 8.1 18.1 4.0 50.3 16.8 11.3 8.2 8.8 0.1 19.5 4.9 75.1 3.8 7.1 3.9 12.1 3.3 4.8 9.3 14.7 3.8 2.6 29.8 3.1 8.7 2.8 1.1 3.4 14.9 16.7 4.5 35.6 29.6 0.6 3.7 0.1 0.0 0.7 1.3 14.5 12.5 3.2 25.2 130.6 68.0 22.9 8.6 26.3 13.1 167.4 3.4 1.7 17.1 12.8 36.6 1.8 392.0 0.2 22.1 36.7 0.0 9.0 20.4 3.6 4.0 13.7 16.1 7.6 416.9 22.0 0.9 30.4 2.0 2.0 23.4 2.0 15.0 13.7 16.0 45.4 233.6 27.4 10.2 50.1 61.2 9.2 23.6 36.2 3.6 168.6 34.8 24.2 30.9 111.6 7.2 10.5 42.8 60.9 23.9 4.9 2.0 1.2 27.5 214.2 26.3 7.2 10.2 4.8 11.0 24.6 41.2 0.3 21.6 8.7 33.2 20.9 CAMK1G "CLICKIII, dJ272L16.1, VWS1" ENSG00000008118 "Calcium/calmodulin dependent protein kinase IG" Q96NX5 1 209583714-209613939 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Allosteric enzyme, Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 40.5;kidney: 11.1;ovary: 21.5" "Group enriched" "Detected in some" 6 "Excitatory neurons: 20.0;Inhibitory neurons: 15.5;Peritubular cells: 6.8;Sertoli cells: 6.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "hTEC/SVTERT24-B: 6.7;hTERT-RPE1: 4.1;SK-MEL-30: 2.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "unprognostic (5.17e-2)" "unprognostic (9.64e-2)" "unprognostic (1.73e-1)" "unprognostic (1.49e-3)" "unprognostic (2.56e-2)" "unprognostic (1.93e-1)" "unprognostic (6.79e-2)" "unprognostic (3.98e-1)" "unprognostic (3.59e-3)" "unprognostic (8.55e-3)" "unprognostic (3.17e-2)" "unprognostic (1.14e-2)" "unprognostic (4.25e-2)" "unprognostic (1.75e-1)" "unprognostic (2.27e-1)" "unprognostic (9.10e-2)" "unprognostic (3.43e-2)" 0.2 2.3 22.6 0.3 27.2 0.4 0.1 0.7 40.5 0.4 0.6 0.5 0.2 1.0 4.3 0.0 0.5 0.7 0.3 23.0 17.3 11.1 0.3 0.7 0.2 6.6 6.1 21.5 0.6 0.0 3.9 1.8 13.8 3.6 0.1 0.5 0.0 5.3 0.3 0.3 0.2 1.3 3.5 5.6 0.1 0.8 26.3 0.1 0.1 0.1 0.2 0.4 0.6 21.1 0.0 0.0 0.2 0.0 0.1 0.0 0.0 1.1 0.2 0.4 0.1 0.0 0.1 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.7 0.4 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 6.7 0.0 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.9 0.0 0.0 0.1 1.2 0.1 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 22.6 27.2 0.7 40.5 23.0 17.3 6.6 6.1 13.8 3.5 26.3 21.1 0.0 0.0 0.0 0.3 0.2 0.1 0.5 0.0 0.0 0.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.4 0.1 0.0 0.0 20.0 0.2 0.0 0.4 0.0 0.7 0.0 0.0 0.0 0.0 0.7 0.0 15.5 0.0 0.0 0.0 0.3 0.1 1.2 0.5 0.0 1.9 0.0 0.3 0.0 0.0 1.2 0.1 0.0 6.8 0.0 0.0 0.0 0.2 0.0 0.1 6.6 0.2 0.7 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.2 CAMK2A "CAMKA, CaMKIIα, CaMKIINalpha, KIAA0968" ENSG00000070808 "Calcium/calmodulin dependent protein kinase II alpha" Q9UQM7 5 150219491-150290291 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 7 "brain: 662.9" "Cell type enriched" "Detected in some" 4 "Excitatory neurons: 245.8" "Cancer enriched" "Detected in single" 13 "glioma: 6.0" "Region enhanced" "Detected in many" "cerebral cortex: 662.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HaCaT: 1.3;SCLC-21H: 3.0;SuSa: 1.4;U-87 MG: 3.9" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebral cortex: 1071.1" "CAB004330, HPA051783, HPA051785, HPA053973" Supported Approved "Plasma membrane,Cell Junctions,Cytosol" NA NA 66000 "Cluster 10: Brain - Neuronal signaling" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" "Cell Junctions, Cytosol" "CAB004330: AB_626788, HPA051783: AB_2681608, HPA051785: AB_2681609, HPA053973: AB_2682328" "unprognostic (7.20e-3)" "unprognostic (6.47e-3)" "unprognostic (6.16e-3)" "unprognostic (4.85e-2)" "unprognostic (4.25e-2)" "unprognostic (1.06e-3)" "unprognostic (1.13e-1)" "unprognostic (6.19e-3)" "unprognostic (3.07e-1)" "unprognostic (1.05e-1)" "unprognostic (4.49e-2)" "unprognostic (1.41e-2)" "unprognostic (2.00e-8)" "unprognostic (2.71e-4)" "unprognostic (1.68e-1)" "unprognostic (1.70e-2)" "unprognostic (1.36e-3)" 0.2 0.9 161.7 0.2 230.9 0.1 0.1 0.0 662.9 1.2 0.0 1.0 0.1 2.8 0.3 1.3 1.5 0.3 4.8 453.1 0.0 0.7 0.2 0.9 0.0 0.0 0.0 0.4 0.1 0.0 3.5 0.3 0.0 0.8 0.2 1.9 0.7 0.4 95.0 0.7 0.4 2.4 0.0 0.3 0.5 0.1 0.0 0.0 0.1 34.7 0.0 2.0 0.7 99.6 0.0 0.1 0.2 0.0 0.0 0.1 0.0 0.1 0.8 0.5 0.3 0.0 0.0 0.0 0.0 0.4 0.0 1.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.2 0.1 0.9 0.0 0.7 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 3.0 0.0 0.1 0.0 0.1 1.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 3.9 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 161.7 230.9 0.0 662.9 453.1 0.0 0.0 0.0 0.0 0.0 0.0 99.6 0.0 0.0 0.0 12.1 0.0 3.4 0.0 0.0 0.0 5.1 0.0 0.0 14.9 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.2 0.2 0.0 0.0 245.8 0.0 0.1 2.2 0.0 0.2 0.0 0.0 0.0 0.0 2.1 0.0 55.5 0.0 0.0 0.0 0.8 0.3 0.0 0.0 3.6 9.4 0.0 0.4 0.0 8.5 8.1 0.0 0.0 0.4 0.0 0.0 0.0 1.0 0.0 0.1 0.0 3.6 1.8 0.0 0.3 0.0 1.4 0.3 0.2 0.0 0.0 0.0 CAMK2B "CAM2, CAMK2, CAMKB, CaMKIIβ" ENSG00000058404 "Calcium/calmodulin dependent protein kinase II beta" Q13554 7 44217150-44334577 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Differentiation, Neurogenesis" "Actin-binding, Calmodulin-binding, Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 248.8;skeletal muscle: 132.5" "Cell type enriched" "Detected in many" 7 "Bipolar cells: 857.4" "Cancer enhanced" "Detected in many" "glioma: 6.0;thyroid cancer: 6.1" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enriched" "Detected in some" 7 "SCLC-21H: 75.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB006849, HPA026307, HPA051783, HPA051785, HPA053973" Enhanced Supported Supported "Plasma membrane,Cell Junctions,Cytosol" NA NA 600000 "Cluster 11: Basophils - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 56: Bipolar cells - Visual perception" "Plasma membrane" "Cell Junctions, Cytosol" "CAB006849: , HPA026307: AB_1845941, HPA051783: AB_2681608, HPA051785: AB_2681609, HPA053973: AB_2682328" "unprognostic (1.88e-3)" "unprognostic (4.49e-2)" "unprognostic (3.55e-3)" "unprognostic (1.36e-2)" "unprognostic (5.25e-2)" "unprognostic (2.90e-2)" "unprognostic (8.78e-2)" "unprognostic (1.09e-1)" "unprognostic (1.44e-1)" "unprognostic (2.71e-1)" "unprognostic (1.17e-2)" "unprognostic (1.60e-2)" "unprognostic (5.23e-7)" "unprognostic (7.04e-2)" "unprognostic (2.34e-1)" "unprognostic (3.15e-2)" "unprognostic (3.95e-2)" 0.5 11.3 77.9 0.6 109.0 0.1 1.4 113.0 248.8 0.1 0.0 1.0 1.0 0.2 28.3 1.4 1.1 0.2 65.4 197.6 12.6 1.6 7.7 0.3 1.3 4.4 11.9 0.3 3.8 6.1 51.3 0.1 4.6 3.2 0.4 21.4 1.4 1.6 132.5 1.2 0.9 0.1 3.2 0.3 2.3 2.1 25.9 0.8 20.3 59.2 1.6 0.0 0.3 80.4 0.0 0.8 0.4 0.6 0.0 0.4 0.4 0.3 0.1 0.3 0.0 0.3 0.1 0.2 1.6 0.4 0.1 0.3 0.4 1.4 0.1 2.0 4.5 0.1 0.2 0.2 0.1 0.0 0.9 0.1 0.0 0.0 0.5 0.2 0.0 0.0 0.0 0.8 0.1 10.1 0.0 0.4 0.2 0.1 4.4 0.2 1.7 0.3 0.0 0.0 75.5 4.0 0.4 0.0 0.0 0.1 3.5 0.3 0.4 0.5 0.7 0.4 0.1 0.9 0.8 0.2 0.2 0.0 0.5 1.0 0.1 0.2 0.1 0.2 0.2 0.2 0.2 0.1 0.1 0.3 0.2 0.2 0.4 0.7 0.3 0.2 0.2 0.2 77.9 109.0 113.0 248.8 197.6 12.6 4.4 11.9 4.6 3.2 25.9 80.4 0.1 0.0 0.0 67.3 0.2 1.1 21.5 0.0 10.8 857.4 3.1 17.5 88.9 2.8 0.0 0.0 45.9 0.1 0.0 0.5 9.8 0.0 0.9 2.3 0.4 1.6 40.7 0.0 111.4 0.0 0.2 2.9 4.1 5.6 4.5 15.4 0.0 4.3 0.2 60.6 90.9 1.5 2.0 0.6 0.4 2.9 1.8 0.5 1.8 5.6 0.0 23.2 0.0 19.6 5.4 0.1 1.2 0.0 0.1 3.3 0.1 1.9 0.0 53.1 0.0 6.9 1.7 0.2 7.8 0.9 0.4 0.3 0.2 0.2 0.3 6.6 CAMK2D CAMKD ENSG00000145349 "Calcium/calmodulin dependent protein kinase II delta" Q13557 4 113451032-113761927 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 159.3" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 272.9;Excitatory neurons: 182.9;Inhibitory neurons: 200.0;Microglial cells: 187.4;Oligodendrocyte precursor cells: 203.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "ASC TERT1: 272.6" "Low region specificity" "Detected in all" "HPA026281, HPA051783, HPA051785, HPA053973" Approved Approved "Plasma membrane,Cell Junctions,Cytosol" NA NA 240000 "Cluster 21: B-cells - Adaptive immune response" "Cluster 38: Heart - Muscle contraction" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane" "Cell Junctions, Cytosol" "HPA026281: AB_1845944, HPA051783: AB_2681608, HPA051785: AB_2681609, HPA053973: AB_2682328" "unprognostic (2.14e-2)" "unprognostic (3.17e-1)" "unprognostic (2.13e-1)" "unprognostic (7.49e-2)" "unprognostic (2.19e-1)" "unprognostic (5.09e-1)" "unprognostic (4.26e-2)" "unprognostic (1.17e-1)" "unprognostic (2.26e-1)" "unprognostic (2.62e-1)" "unprognostic (7.81e-2)" "unprognostic (7.91e-3)" "unprognostic (2.62e-2)" "unprognostic (1.46e-1)" "unprognostic (9.68e-2)" "unprognostic (1.87e-1)" "unprognostic (1.90e-2)" 28.6 25.6 52.7 26.6 45.1 5.7 21.0 45.8 52.0 18.9 1.6 36.4 28.8 23.5 9.8 29.7 18.8 30.7 159.3 60.2 23.9 19.3 37.3 22.9 35.2 11.8 33.9 25.4 15.2 56.5 9.1 19.8 12.6 32.2 39.1 79.2 13.4 41.7 105.1 15.8 34.1 24.9 21.0 18.4 37.1 19.8 46.7 16.3 23.7 60.0 31.4 27.4 19.7 22.9 4.8 62.5 67.5 22.8 144.0 272.6 24.0 145.4 96.3 56.0 48.0 42.3 17.6 91.2 20.7 102.3 70.7 2.1 42.6 22.8 56.6 35.1 10.8 0.0 22.0 49.2 73.0 0.1 0.2 176.3 30.5 43.5 107.1 88.5 50.6 11.3 3.6 39.4 106.8 17.1 9.3 3.6 9.8 60.3 22.8 17.9 79.0 0.4 57.3 42.7 18.2 18.3 20.0 29.3 19.5 55.9 0.6 23.7 30.7 146.9 34.8 63.6 29.1 30.4 16.5 76.7 75.7 5.5 70.8 0.0 12.7 0.0 6.7 7.0 12.7 11.2 6.6 7.5 15.7 22.6 7.4 6.5 0.9 9.7 2.5 0.1 13.2 7.7 52.7 45.1 45.8 52.0 60.2 23.9 11.8 33.9 12.6 21.0 46.7 22.9 43.7 41.7 37.6 128.3 55.1 18.4 16.6 8.3 22.8 83.3 14.0 17.1 272.9 62.9 24.7 29.5 87.6 0.5 19.0 70.9 5.9 8.4 3.2 18.2 35.2 27.2 103.8 3.6 182.9 20.1 0.4 50.1 71.9 47.0 10.1 13.0 24.3 57.2 18.6 72.3 200.0 88.1 14.2 17.3 22.3 6.2 20.2 31.5 5.4 187.4 16.0 35.9 28.8 203.1 128.0 11.6 57.3 19.9 20.4 36.2 52.4 23.1 21.7 74.0 6.6 32.8 44.4 3.1 3.4 37.1 31.8 1.1 27.8 12.3 48.6 27.5 CAMK2G CAMKG ENSG00000148660 "Calcium/calmodulin dependent protein kinase II gamma" Q13555 10 73812501-73874591 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Differentiation, Neurogenesis" "Calmodulin-binding, Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 154.3" "Cell type enhanced" "Detected in many" "Astrocytes: 410.7;Cytotrophoblasts: 163.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "eosinophil: 133.9" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "PC-3: 154.8;SK-BR-3: 177.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040656, HPA051783, HPA051785, HPA053973" Approved Approved "Plasma membrane,Cell Junctions,Cytosol" NA NA 200000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 80: Striated muscle - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 47: Cytotrophoblasts - Unknown function" "Plasma membrane" "Cell Junctions, Cytosol" "HPA040656: AB_2677065, HPA051783: AB_2681608, HPA051785: AB_2681609, HPA053973: AB_2682328" "unprognostic (8.63e-3)" "unprognostic (2.01e-1)" "unprognostic (1.05e-1)" "unprognostic (3.46e-3)" "unprognostic (4.27e-2)" "unprognostic (1.82e-2)" "unprognostic (2.19e-2)" "unprognostic (2.36e-1)" "unprognostic (2.48e-1)" "unprognostic (6.25e-2)" "unprognostic (2.92e-2)" "unprognostic (1.08e-1)" "unprognostic (1.73e-2)" "unprognostic (2.48e-1)" "unprognostic (8.28e-2)" "unprognostic (9.64e-2)" "unprognostic (4.62e-2)" 22.0 14.0 86.1 17.0 92.6 34.5 15.2 79.9 137.8 24.1 44.1 101.1 34.2 45.2 14.5 34.7 30.6 17.8 11.8 91.3 79.0 19.3 14.5 18.8 16.2 96.1 96.5 12.7 10.3 12.3 14.1 27.3 94.1 31.1 26.1 42.4 22.9 49.6 154.3 17.3 41.5 43.9 91.4 24.9 30.4 6.5 102.5 15.7 13.6 84.8 14.9 58.4 25.8 91.9 35.7 24.6 22.5 43.9 16.7 26.1 26.3 25.8 41.0 31.9 26.1 39.8 37.2 27.4 25.7 32.4 12.4 54.9 17.5 20.5 25.3 24.0 22.2 18.2 20.4 17.8 8.1 24.7 29.1 14.4 17.7 32.5 22.1 50.4 28.3 32.5 19.5 37.9 19.0 25.2 41.7 37.5 16.5 21.3 154.8 36.5 25.3 13.7 17.2 51.5 11.5 28.4 15.0 177.4 11.9 16.5 33.2 15.0 36.7 24.9 40.0 13.4 33.3 11.9 14.9 24.8 26.5 69.2 8.8 31.0 17.9 133.9 23.1 7.9 28.5 13.9 26.3 25.0 23.0 12.7 24.5 24.1 115.8 34.0 15.1 7.9 27.7 17.5 86.1 92.6 79.9 137.8 91.3 79.0 96.1 96.5 94.1 91.4 102.5 91.9 19.3 16.0 11.7 410.7 22.2 9.4 8.7 9.2 14.2 63.3 14.8 16.3 6.7 12.8 15.5 7.3 100.1 163.6 21.3 46.2 13.7 13.3 2.0 6.3 6.4 20.2 23.9 13.3 107.9 19.6 45.2 12.0 14.8 7.5 16.5 20.2 16.4 9.6 27.2 26.9 89.7 24.8 10.2 18.9 16.3 3.1 12.8 15.8 12.4 43.1 18.3 17.7 26.8 61.9 16.9 22.0 65.5 18.8 13.6 8.2 77.1 26.9 10.4 77.0 46.0 11.2 50.8 0.8 13.5 26.5 12.6 81.1 30.3 5.2 32.1 13.7 CAMK4 "CaMK-GR, CaMKIV" ENSG00000152495 "Calcium/calmodulin dependent protein kinase IV" Q16566 5 111223653-111494886 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Adaptive immunity, Immunity, Inflammatory response" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "brain: 70.4;lymphoid tissue: 55.4" "Cell type enhanced" "Detected in many" "Bipolar cells: 70.9;Early spermatids: 306.2;Excitatory neurons: 212.2;Inhibitory neurons: 131.8;Late spermatids: 108.4;Oligodendrocyte precursor cells: 133.2;T-cells: 83.3" "Low cancer specificity" "Detected in some" "Group enriched" "Detected in many" 6 "basal ganglia: 30.6;cerebellum: 70.4" "Group enriched" "Detected in many" 4 "MAIT T-cell: 24.3;memory CD4 T-cell: 17.3;memory CD8 T-cell: 13.5;naive CD4 T-cell: 33.1;naive CD8 T-cell: 18.5;T-reg: 21.3" "Lineage enriched" "Detected in many" 23 "T-cells: 33.1" "Cell line enhanced" "Detected in many" "HDLM-2: 88.9;JURKAT: 61.3;MOLT-4: 27.9;SH-SY5Y: 33.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004347, HPA011753, HPA017206" Approved Supported "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 58: T-cells - T-cell receptor" "Nucleoplasm, Nucleoli fibrillar center" "CAB004347: AB_626793, HPA011753: AB_1845950, HPA017206: AB_1845949" "unprognostic (2.99e-5)" "unprognostic (7.19e-2)" "unprognostic (3.43e-3)" "unprognostic (5.11e-2)" "unprognostic (4.75e-3)" "unprognostic (3.48e-2)" "unprognostic (7.66e-4)" "unprognostic (7.22e-3)" "unprognostic (2.49e-1)" "unprognostic (2.92e-1)" "unprognostic (1.09e-1)" "unprognostic (1.46e-1)" "unprognostic (2.23e-5)" "unprognostic (2.42e-2)" "unprognostic (3.01e-2)" "unprognostic (1.66e-1)" "unprognostic (9.99e-3)" 0.4 3.8 5.0 4.4 30.6 3.1 0.4 70.4 8.2 0.9 0.0 1.3 1.4 0.6 0.3 0.7 0.3 1.5 0.1 7.6 0.0 0.7 1.4 1.1 8.1 0.0 0.4 0.6 0.4 0.0 0.6 0.2 1.4 3.4 1.4 4.7 0.4 1.4 0.1 0.1 2.3 0.8 0.0 2.6 1.5 9.4 0.8 55.4 0.2 0.0 5.2 1.7 0.4 0.0 0.0 0.0 3.1 2.1 0.6 2.3 0.0 0.8 6.8 8.0 7.8 0.0 0.1 0.0 4.0 0.4 5.4 0.3 6.8 0.8 5.8 88.9 5.2 1.3 2.8 0.0 0.2 0.6 0.3 0.3 0.0 16.8 1.7 4.9 1.4 61.3 0.0 3.3 0.4 0.0 27.9 0.0 4.1 0.0 0.2 4.0 5.0 0.2 2.9 0.1 18.8 33.5 1.2 0.0 5.6 0.2 0.1 0.5 0.1 16.3 9.5 0.1 14.7 2.6 0.3 0.0 8.0 0.0 6.3 0.1 0.0 0.0 4.8 0.0 24.3 1.3 17.3 13.5 0.0 0.3 33.1 18.5 0.9 1.4 0.0 0.1 21.3 5.5 5.0 30.6 70.4 8.2 7.6 0.0 0.0 0.4 1.4 0.0 0.8 0.0 1.8 0.0 1.1 57.8 9.4 1.1 0.3 1.3 8.6 70.9 0.6 0.6 5.3 0.0 0.0 0.0 0.0 0.1 3.1 0.1 0.0 0.1 306.2 0.2 1.6 1.1 0.0 0.0 212.2 0.0 0.2 4.6 3.6 0.4 4.5 0.3 0.7 0.3 0.2 0.0 131.8 0.8 0.0 1.3 2.1 108.4 4.1 2.0 0.0 12.2 2.7 2.8 1.0 133.2 5.4 1.2 0.0 1.5 11.5 0.5 0.0 0.1 0.1 4.3 0.0 0.6 3.8 30.3 6.2 2.4 1.0 0.0 83.3 0.1 0.0 0.3 CAMKK1 "CAMKKA, DKFZp761M0423, MGC34095" ENSG00000004660 "Calcium/calmodulin dependent protein kinase kinase 1" Q8N5S9 17 3860315-3894891 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 54.4" "Cell type enhanced" "Detected in many" "Bipolar cells: 41.9;Excitatory neurons: 52.7;Rod photoreceptor cells: 25.1" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in many" 5 "amygdala: 21.5;basal ganglia: 24.2;cerebral cortex: 54.4;hippocampal formation: 24.8;white matter: 31.9" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HeLa: 28.3;U-87 MG: 27.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009111, HPA028062" Approved Supported Cytosol No No "Cluster 45: Eosinophils - Innate immune response" "Cluster 10: Brain - Neuronal signaling" "Cluster 20: HeLa - Mitochondria" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "CAB009111: AB_2068406, HPA028062: AB_1845954" "unprognostic (1.39e-2)" "unprognostic (2.13e-1)" "unprognostic (8.66e-3)" "unprognostic (4.40e-3)" "unprognostic (2.94e-3)" "unprognostic (4.79e-2)" "unprognostic (1.98e-1)" "unprognostic (4.47e-3)" "unprognostic (8.23e-2)" "unprognostic (1.03e-2)" "prognostic favorable (2.65e-4)" "unprognostic (1.98e-1)" "unprognostic (1.59e-1)" "unprognostic (7.19e-2)" "unprognostic (8.70e-2)" "unprognostic (8.36e-2)" "unprognostic (3.10e-1)" 6.0 10.7 21.5 5.2 24.2 4.1 5.4 5.6 54.4 12.7 0.0 10.2 2.9 13.1 4.8 6.8 7.0 3.6 5.7 24.8 0.8 3.6 1.0 5.0 2.6 6.0 1.9 8.1 12.7 4.1 24.4 2.0 6.6 8.2 2.7 12.0 29.9 10.4 3.4 15.9 6.9 5.8 0.6 9.6 4.2 10.1 5.0 5.1 7.6 1.6 2.3 16.1 13.8 31.9 7.0 11.8 1.2 5.9 4.1 7.2 0.4 4.7 5.1 4.4 2.0 4.3 2.1 4.2 5.0 9.1 4.6 20.3 3.2 5.8 2.7 0.1 10.7 4.8 28.3 1.6 4.2 0.7 3.6 5.5 4.9 8.4 2.8 3.8 2.0 6.0 3.8 0.2 2.2 1.9 6.0 2.7 1.3 10.1 11.0 3.0 5.1 4.8 4.8 4.4 6.7 3.8 1.8 13.9 3.1 0.7 5.3 1.6 2.8 7.6 10.2 9.9 4.0 0.5 0.3 0.1 27.9 4.0 1.0 0.0 0.9 1.9 0.2 2.0 0.5 0.0 0.3 0.2 0.8 0.0 0.3 0.1 2.7 0.0 2.1 0.4 0.0 0.7 21.5 24.2 5.6 54.4 24.8 0.8 6.0 1.9 6.6 0.6 5.0 31.9 5.5 6.4 12.5 8.1 7.0 3.7 2.1 1.5 1.8 41.9 2.5 1.3 6.3 0.0 3.3 1.8 16.7 0.3 3.4 1.7 0.0 0.4 0.1 1.7 7.8 5.6 4.2 0.4 52.7 1.6 0.1 5.5 0.5 1.6 17.1 0.9 2.9 0.6 4.3 8.4 13.9 1.3 2.0 3.2 3.3 1.3 1.2 6.9 8.8 9.4 0.8 4.7 2.1 4.0 3.5 0.6 0.6 1.2 2.2 2.2 0.2 0.3 1.5 25.1 0.0 2.0 1.7 0.1 1.1 4.1 5.4 0.3 2.9 1.2 2.1 1.1 CAMKK2 "CAMKK, CAMKKB, KIAA0787, MGC15254" ENSG00000110931 "Calcium/calmodulin dependent protein kinase kinase 2" Q96RR4 12 121237675-121298308 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 135.4" "Cell type enhanced" "Detected in many" "Excitatory neurons: 64.8;Horizontal cells: 62.2;Late spermatids: 89.6" "Cancer enriched" "Detected in all" 5 "prostate cancer: 56.3" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 4 "classical monocyte: 32.7;eosinophil: 62.1;intermediate monocyte: 42.3;myeloid DC: 15.9;neutrophil: 39.2;non-classical monocyte: 39.5" "Group enriched" "Detected in all" 5 "dendritic cells: 15.9;granulocytes: 62.1;monocytes: 42.3" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017389, HPA063713" Approved Supported Supported Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 29: U-266 - Adaptive immune response" "Cluster 31: Spermatids - Spermatogenesis" Cytosol "HPA017389: AB_1845956, HPA063713: " "unprognostic (5.08e-2)" "unprognostic (1.81e-1)" "unprognostic (1.38e-1)" "unprognostic (3.08e-1)" "unprognostic (1.88e-1)" "unprognostic (1.12e-1)" "unprognostic (2.62e-3)" "unprognostic (2.80e-2)" "unprognostic (1.93e-1)" "unprognostic (7.76e-2)" "unprognostic (5.01e-2)" "unprognostic (1.70e-1)" "unprognostic (1.75e-1)" "unprognostic (4.13e-1)" "unprognostic (3.34e-2)" "unprognostic (1.67e-1)" "unprognostic (1.38e-1)" 26.0 16.7 39.6 17.0 56.2 30.8 22.7 135.4 65.5 22.3 14.3 22.8 25.7 22.9 10.8 17.5 27.5 12.9 17.8 44.8 24.8 16.7 30.9 23.6 15.3 20.8 20.1 27.4 16.8 12.4 11.8 15.3 24.9 29.5 19.4 7.1 18.6 23.8 11.5 18.3 26.6 20.7 18.3 39.6 24.0 7.0 23.6 13.4 17.1 11.2 15.6 25.9 21.1 42.7 27.9 20.5 16.3 30.9 46.7 43.0 22.8 22.0 23.8 19.0 17.3 21.4 12.1 43.0 18.1 48.1 14.1 22.7 20.0 25.8 15.1 29.3 35.9 22.0 14.4 21.3 31.1 50.0 20.0 28.2 37.2 18.0 41.4 26.0 45.0 33.5 25.2 23.6 18.4 27.2 55.8 40.6 11.7 24.9 22.7 35.3 18.4 37.7 18.8 32.1 60.2 22.4 31.5 16.5 19.1 12.9 39.7 62.0 32.2 14.8 11.8 13.1 13.0 84.8 55.6 32.7 27.7 34.4 16.0 2.0 32.7 62.1 4.7 42.3 4.6 4.8 3.5 4.2 15.9 2.8 3.2 3.8 39.2 8.6 39.5 3.6 3.3 15.8 39.6 56.2 135.4 65.5 44.8 24.8 20.8 20.1 24.9 18.3 23.6 42.7 25.4 9.6 5.6 9.8 5.7 7.9 6.0 8.1 8.0 22.2 11.6 10.5 8.2 12.8 8.3 9.2 2.1 9.2 10.6 18.2 3.9 9.6 16.0 6.5 19.6 21.9 34.3 12.0 64.8 10.4 8.2 18.0 13.3 10.9 6.3 23.3 15.0 19.7 7.9 62.2 21.4 16.2 8.2 14.8 15.6 89.6 20.5 16.6 8.8 12.2 36.3 5.4 12.3 10.1 19.3 8.5 10.9 31.6 11.9 16.5 26.6 9.6 7.2 7.0 19.7 7.7 20.6 0.8 2.9 13.3 6.0 3.4 7.6 32.7 17.6 6.3 CARM1 PRMT4 ENSG00000142453 "Coactivator associated arginine methyltransferase 1" Q86X55 19 10871553-10923075 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction, Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 110.5" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032961, HPA043561, HPA048073, HPA069313" Supported Enhanced Nucleoplasm "Intracellular and membrane" NA NA 19000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 80: Striated muscle - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "CAB032961: AB_2068446, HPA043561: AB_2678554, HPA048073: AB_2680250, HPA069313: " "unprognostic (9.46e-2)" "unprognostic (3.61e-1)" "unprognostic (2.94e-2)" "unprognostic (2.23e-1)" "unprognostic (2.69e-2)" "unprognostic (3.13e-2)" "unprognostic (1.66e-3)" "unprognostic (3.76e-2)" "unprognostic (7.81e-2)" "unprognostic (6.18e-2)" "unprognostic (9.31e-2)" "unprognostic (7.25e-2)" "prognostic unfavorable (7.88e-6)" "unprognostic (1.71e-2)" "unprognostic (6.26e-2)" "unprognostic (1.00e-1)" "prognostic unfavorable (8.37e-4)" 20.3 17.1 24.7 19.6 26.6 22.7 17.6 18.9 34.1 30.6 17.2 28.4 17.3 31.7 7.8 36.7 23.4 14.7 25.4 27.6 23.7 18.8 20.1 16.4 19.8 22.8 21.8 21.9 22.3 11.5 14.8 20.4 22.6 20.2 14.3 6.4 20.2 17.5 110.5 22.6 20.9 21.3 19.9 18.6 20.3 45.4 22.6 10.9 13.4 72.4 15.4 26.3 28.0 26.0 62.5 46.8 64.9 88.3 52.5 71.1 63.2 42.8 75.6 63.9 61.0 73.4 21.8 85.2 52.4 77.4 32.1 58.0 65.4 66.2 40.1 98.4 52.7 26.5 29.1 89.9 44.8 39.3 33.9 49.0 42.4 43.8 52.4 35.9 82.1 67.9 65.8 79.2 38.2 116.7 70.0 34.3 81.4 40.7 74.8 97.5 32.8 100.7 38.9 29.7 47.0 45.1 30.7 36.2 43.6 31.7 38.4 35.3 48.7 75.4 43.2 72.3 54.0 75.0 64.1 77.2 51.1 63.8 35.3 0.0 0.2 0.0 0.1 0.2 0.1 0.2 0.1 0.5 0.2 0.2 0.1 0.1 0.0 0.0 0.1 0.3 0.1 0.1 24.7 26.6 18.9 34.1 27.6 23.7 22.8 21.8 22.6 19.9 22.6 26.0 12.9 9.6 12.2 7.2 11.6 7.8 5.9 4.1 12.0 36.4 14.0 13.7 1.1 14.3 6.5 9.2 52.1 18.5 6.4 42.3 7.9 13.4 32.7 20.1 30.8 12.7 27.6 30.7 12.9 19.7 33.1 13.8 13.7 25.4 1.3 17.8 12.8 27.8 26.7 45.4 10.6 24.9 4.1 20.0 10.9 23.5 28.3 14.8 5.4 5.6 23.9 8.7 4.1 10.6 5.8 24.8 27.2 19.2 11.7 14.1 22.6 9.2 7.4 21.1 6.6 19.6 13.0 23.8 17.5 25.7 7.0 12.0 6.5 6.6 25.7 11.8 CASK "CAGH39, FGS4, LIN2, TNRC8" ENSG00000147044 "Calcium/calmodulin dependent serine protein kinase" O14936 X 41514934-41923554 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Inhibitory neurons: 135.8;Oligodendrocyte precursor cells: 447.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "basophil: 47.1" "Lineage enriched" "Detected in many" 10 "granulocytes: 47.1" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001949, HPA023857" Enhanced Approved Nucleoplasm,Cytosol NA NA "Cluster 46: Basophils - DNA binding" "Cluster 9: Intestine - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 68: Oligodendrocytes - Mixed function" Nucleoplasm Cytosol "CAB001949: , HPA023857: AB_1846035" "unprognostic (6.30e-2)" "unprognostic (3.78e-2)" "unprognostic (1.48e-1)" "unprognostic (2.48e-3)" "unprognostic (1.56e-1)" "unprognostic (1.29e-1)" "unprognostic (1.42e-3)" "unprognostic (3.58e-1)" "unprognostic (1.02e-1)" "unprognostic (5.85e-3)" "prognostic unfavorable (6.11e-5)" "unprognostic (1.13e-1)" "unprognostic (1.05e-1)" "unprognostic (8.72e-2)" "unprognostic (1.15e-2)" "unprognostic (2.13e-2)" "unprognostic (2.85e-2)" 10.2 11.1 13.6 11.9 12.9 7.3 15.7 12.3 11.1 11.6 12.4 25.3 32.1 11.1 9.4 13.7 10.5 18.5 6.8 14.2 17.1 16.4 13.4 12.2 12.5 13.2 19.4 13.5 12.8 11.8 6.3 16.3 15.7 10.6 27.3 19.8 13.2 8.3 5.0 9.3 31.9 12.0 15.4 12.4 19.8 3.6 25.2 15.4 10.6 6.1 10.4 15.3 8.8 18.0 27.4 32.5 31.4 19.1 21.6 18.6 10.9 23.2 18.7 13.2 12.3 72.3 42.6 0.4 12.0 29.3 23.8 52.3 35.2 23.2 22.8 25.4 20.9 0.6 27.7 26.2 22.1 4.4 3.6 19.8 63.2 25.1 30.1 27.5 11.6 15.3 2.2 21.3 30.2 30.9 8.4 2.2 29.7 37.6 22.6 12.7 79.8 13.2 31.2 54.8 29.7 15.6 43.7 17.7 13.9 52.7 19.0 0.8 14.2 24.4 25.8 22.1 13.3 7.6 5.2 9.5 24.4 3.1 16.9 47.1 1.5 8.7 0.8 1.1 0.8 0.7 0.9 1.3 0.4 0.9 1.2 1.1 1.7 4.3 0.7 0.5 4.5 0.6 13.6 12.9 12.3 11.1 14.2 17.1 13.2 19.4 15.7 15.4 25.2 18.0 13.0 12.8 20.4 101.9 8.8 32.6 42.7 11.1 8.0 42.2 23.7 16.5 7.8 8.6 14.6 7.3 22.9 2.0 12.1 25.8 50.9 13.7 0.9 9.6 24.1 16.0 13.8 0.8 96.6 14.5 0.7 18.8 18.8 11.9 0.0 17.4 8.9 15.0 21.3 50.5 135.8 28.7 14.2 2.8 21.5 1.0 9.9 10.7 10.6 60.0 2.5 9.3 0.0 447.8 59.7 22.1 24.1 9.4 7.0 16.4 35.2 20.9 15.7 25.7 19.7 38.2 20.6 2.9 2.1 13.9 32.5 1.6 26.5 47.7 41.8 33.2 CBL "c-Cbl, CBL2, RNF55" ENSG00000110395 "Cbl proto-oncogene" P22681 11 119206298-119313926 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 8.6" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004350, HPA027956" Enhanced Approved Cytosol NA NA 67000 "Cluster 1: Neutrophils - Mixed function" "Cluster 3: T-cells - Adaptive immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Cytosol "CAB004350: AB_2244054, HPA027956: AB_10601094" "unprognostic (2.52e-1)" "unprognostic (1.32e-3)" "unprognostic (1.60e-1)" "unprognostic (1.15e-1)" "unprognostic (1.50e-2)" "unprognostic (2.92e-1)" "unprognostic (4.10e-3)" "unprognostic (9.75e-2)" "unprognostic (1.72e-1)" "unprognostic (1.52e-1)" "unprognostic (1.03e-2)" "unprognostic (5.23e-2)" "unprognostic (5.21e-2)" "unprognostic (5.27e-2)" "unprognostic (1.52e-1)" "unprognostic (1.12e-1)" "unprognostic (5.85e-2)" 6.8 4.0 5.6 9.5 5.7 8.5 5.6 5.3 6.5 5.0 0.2 6.2 3.9 6.5 3.4 5.6 5.6 3.9 4.1 5.3 8.1 4.4 2.7 7.9 10.7 5.8 6.3 3.7 3.8 6.1 2.9 6.4 6.5 4.0 5.0 8.3 3.6 4.6 2.5 5.2 6.6 7.4 5.2 9.9 5.2 18.2 7.9 22.5 4.1 3.2 11.2 5.8 4.9 6.0 10.7 7.6 26.6 16.7 7.8 9.2 16.0 11.2 11.4 10.8 10.2 16.7 12.6 25.1 10.0 14.0 21.7 15.2 18.4 9.4 22.7 14.8 4.7 26.4 6.2 5.1 9.5 30.3 27.9 8.1 10.1 26.7 28.4 11.1 26.3 23.7 21.7 9.9 19.1 11.3 16.2 17.0 14.0 9.2 8.8 17.5 13.5 4.6 9.3 8.2 3.7 11.3 20.9 8.8 7.3 18.1 9.4 24.8 22.8 16.0 11.5 11.6 14.7 3.3 5.3 19.9 6.7 25.4 11.9 0.8 2.4 2.0 0.9 2.8 0.8 1.5 1.1 0.9 2.6 1.2 1.2 1.3 8.6 0.4 2.5 1.4 1.0 0.9 5.6 5.7 5.3 6.5 5.3 8.1 5.8 6.3 6.5 5.2 7.9 6.0 23.2 9.6 8.3 23.5 23.2 18.0 5.9 7.5 19.4 14.0 13.6 11.7 8.8 5.7 6.0 11.0 45.9 6.3 24.0 7.6 1.9 6.1 28.2 9.9 19.6 23.2 8.4 5.7 38.5 6.7 10.5 9.4 9.2 16.8 3.8 20.8 20.0 3.1 16.0 13.5 39.1 4.9 2.0 59.1 43.2 42.0 7.8 41.2 16.0 45.0 46.8 13.2 22.6 26.2 19.6 10.6 11.6 12.8 19.7 8.0 5.1 5.4 4.8 33.3 26.3 11.6 22.7 38.0 36.2 18.5 21.9 7.0 24.9 10.6 5.1 10.9 CBLB "Cbl-b, RNF56" ENSG00000114423 "Cbl proto-oncogene B" Q13191 3 105655461-105869552 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "dendritic cells: 113.7;Inhibitory neurons: 112.5;Oligodendrocyte precursor cells: 123.1;T-cells: 111.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "U-138 MG: 32.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018327, HPA019880" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 20: HeLa - Mitochondria" "Cluster 24: Non-specific - Transcription regulation" Cytosol Nucleoplasm "HPA018327: AB_1846097, HPA019880: AB_1846099" "unprognostic (2.65e-1)" "unprognostic (9.42e-2)" "unprognostic (1.72e-2)" "unprognostic (2.38e-1)" "unprognostic (5.89e-3)" "unprognostic (2.80e-2)" "unprognostic (8.18e-2)" "unprognostic (1.10e-1)" "unprognostic (7.05e-2)" "unprognostic (1.66e-1)" "unprognostic (9.29e-2)" "unprognostic (1.50e-2)" "unprognostic (1.43e-2)" "unprognostic (8.21e-2)" "unprognostic (2.83e-1)" "unprognostic (1.20e-2)" "unprognostic (3.09e-2)" 17.3 5.8 5.6 6.7 4.6 11.9 11.0 17.4 5.9 6.8 5.8 6.3 6.2 6.3 4.3 3.5 8.8 8.4 12.2 5.2 7.3 4.3 4.4 9.9 14.5 4.4 5.3 10.0 3.6 2.3 3.8 6.5 5.7 4.7 5.1 9.2 6.7 2.3 7.8 6.8 8.2 3.0 2.0 8.5 8.3 6.4 6.5 4.3 9.1 5.1 6.9 10.0 6.5 4.0 2.4 3.2 10.7 5.4 11.8 12.1 6.8 7.6 4.0 2.3 3.7 4.1 2.6 5.2 5.4 4.2 3.6 3.9 1.5 1.4 2.8 3.8 4.0 2.8 16.1 2.7 17.7 2.0 2.0 11.9 4.3 6.2 16.7 8.5 7.9 5.2 3.0 15.5 5.0 2.8 2.9 1.3 3.6 2.9 4.4 6.1 3.1 0.9 5.9 10.2 8.2 8.9 9.5 1.1 11.9 7.3 2.4 4.3 4.8 32.0 2.6 4.5 2.0 8.8 0.7 8.3 8.6 1.7 2.1 0.7 1.4 2.8 8.9 0.9 7.9 2.1 4.6 5.1 1.3 4.8 3.9 7.0 1.0 10.2 2.0 3.1 5.7 1.7 5.6 4.6 17.4 5.9 5.2 7.3 4.4 5.3 5.7 2.0 6.5 4.0 26.0 16.0 6.1 57.8 43.1 10.8 6.9 35.6 25.6 42.6 12.0 9.7 43.7 2.8 13.7 12.9 27.1 10.1 113.7 12.8 5.9 8.4 34.1 20.9 47.0 34.0 12.6 10.8 48.9 7.8 83.2 55.2 43.8 26.4 8.8 21.3 33.2 8.1 13.9 3.3 112.5 18.8 6.1 13.5 17.1 14.4 7.5 14.6 16.0 74.9 9.0 7.5 59.8 123.1 100.3 15.5 8.6 10.9 53.1 8.9 17.6 3.9 20.2 28.9 6.6 23.6 28.9 11.1 13.3 10.3 7.0 45.4 111.5 5.5 9.9 7.0 CBLC "CBL-3, CBL-SL, RNF57" ENSG00000142273 "Cbl proto-oncogene C" Q9ULV8 19 44777869-44800652 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 39.3;intestine: 50.9;skin 1: 42.4" "Cell type enhanced" "Detected in many" "Distal enterocytes: 108.6;Pancreatic endocrine cells: 95.0;Paneth cells: 108.1;Proximal enterocytes: 154.6;Undifferentiated cells: 67.1;Urothelial cells: 76.9" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 43.6;BEWO: 28.9;CACO-2: 28.3;CAPAN-2: 56.9;HaCaT: 41.0;HBEC3-KT: 34.8;hTCEpi: 26.0;OE19: 37.3;RT4: 34.7;SK-BR-3: 31.1" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB008087, HPA035266" Approved Approved Nucleoplasm,Aggresome NA NA "Cluster 37: Intestine - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm Aggresome "CAB008087: AB_2228531, HPA035266: AB_2674542" "unprognostic (1.58e-1)" "unprognostic (2.25e-1)" "unprognostic (8.21e-3)" "unprognostic (1.55e-1)" "unprognostic (3.04e-2)" "unprognostic (3.91e-2)" "unprognostic (1.67e-1)" "unprognostic (2.13e-2)" "unprognostic (3.82e-1)" "unprognostic (7.39e-2)" "unprognostic (1.06e-2)" "unprognostic (1.85e-1)" "prognostic favorable (3.11e-6)" "unprognostic (3.50e-1)" "unprognostic (8.25e-3)" "unprognostic (2.90e-2)" "unprognostic (2.21e-3)" 0.1 0.1 0.0 3.1 0.0 0.0 5.1 0.0 0.1 8.0 0.0 25.0 50.9 0.9 0.1 39.3 2.5 4.4 0.0 0.0 0.0 7.4 21.1 1.3 0.0 0.0 0.0 0.1 20.6 1.6 0.5 0.4 0.0 11.8 11.7 0.1 13.3 2.4 0.1 42.4 38.6 0.6 0.0 0.0 17.7 0.7 0.0 0.3 1.7 0.0 4.0 8.3 18.4 0.0 43.6 0.0 0.0 0.1 0.0 0.0 28.9 0.0 0.0 0.0 0.0 28.3 56.9 0.0 0.0 0.0 0.0 41.0 0.0 34.8 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 26.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 37.3 0.0 0.0 0.0 0.0 0.0 34.7 0.4 0.1 0.0 31.1 0.0 0.2 22.5 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.6 0.0 0.1 15.0 44.0 30.8 16.5 0.0 9.3 7.4 0.2 4.3 27.7 7.3 0.0 5.8 0.2 108.6 1.9 53.8 0.1 7.0 1.3 0.9 17.4 0.0 0.4 48.9 2.3 0.5 59.7 15.5 0.0 0.0 0.0 11.1 0.3 0.0 0.9 40.0 18.3 0.0 1.4 0.3 0.0 0.4 0.0 0.0 0.6 0.0 0.0 1.0 0.3 95.0 108.1 0.0 0.1 34.4 154.6 17.2 9.8 0.0 0.0 0.0 1.3 0.0 2.6 29.9 25.7 2.5 0.7 0.0 67.1 76.9 CBLL1 "FLJ23109, HAKAI, RNF188" ENSG00000105879 "Cbl proto-oncogene like 1" Q75N03 7 107743949-107761667 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Developmental protein, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021773, HPA026699" Enhanced Supported "Nuclear speckles" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" "Nuclear speckles" "HPA021773: AB_1846103, HPA026699: AB_1846104" "unprognostic (1.90e-2)" "unprognostic (2.25e-1)" "unprognostic (8.57e-2)" "unprognostic (3.79e-2)" "unprognostic (8.16e-2)" "unprognostic (7.20e-2)" "unprognostic (1.37e-2)" "unprognostic (3.96e-3)" "unprognostic (4.28e-2)" "unprognostic (2.16e-3)" "unprognostic (1.29e-1)" "unprognostic (1.31e-1)" "unprognostic (2.12e-3)" "unprognostic (9.12e-2)" "unprognostic (2.07e-1)" "unprognostic (1.09e-1)" "unprognostic (8.71e-2)" 11.2 8.1 3.1 12.5 5.3 40.0 15.1 7.8 9.5 12.0 3.0 11.3 9.5 13.5 8.4 11.3 11.2 8.7 10.4 4.2 5.8 10.0 11.2 10.3 16.1 4.1 3.7 14.3 11.7 14.1 5.1 12.0 4.1 16.5 11.1 14.4 8.9 12.7 29.0 10.7 10.3 13.4 3.0 14.2 9.2 19.7 3.7 20.2 13.8 21.0 17.8 11.9 7.2 6.6 27.8 31.1 23.7 30.7 21.7 18.6 16.2 20.5 21.6 22.8 22.5 21.4 27.9 40.6 28.5 23.5 37.6 19.3 33.4 25.0 31.0 28.4 21.1 32.5 23.0 18.2 24.9 49.1 30.9 19.6 22.7 30.7 33.0 17.6 23.8 27.8 53.0 33.3 22.4 48.0 66.5 34.4 34.4 23.3 21.3 30.6 25.4 42.0 17.4 25.5 25.4 39.6 30.7 44.9 23.4 27.7 15.1 24.7 23.4 35.0 25.0 33.4 32.0 53.0 62.3 64.1 21.3 29.8 30.3 88.8 31.1 53.3 39.5 32.0 58.2 39.0 61.9 45.8 36.9 39.8 41.8 40.0 48.9 55.1 38.0 20.1 92.6 48.4 3.1 5.3 7.8 9.5 4.2 5.8 4.1 3.7 4.1 3.0 3.7 6.6 18.2 19.2 11.0 6.5 29.6 23.6 16.7 10.5 27.3 12.2 15.9 13.7 16.4 17.2 10.7 3.7 4.2 10.3 27.6 9.9 7.9 9.7 12.4 15.6 19.8 13.5 16.8 39.1 13.9 10.8 9.5 12.6 10.7 13.7 13.3 16.6 12.5 11.0 10.7 10.1 13.1 8.0 8.2 23.3 12.4 5.4 9.3 15.1 19.6 15.9 15.0 7.6 25.7 10.1 20.5 10.1 15.0 11.7 17.3 16.2 8.5 11.2 8.9 14.4 19.7 13.2 14.5 27.2 14.3 19.5 19.9 10.3 27.3 9.5 10.0 18.4 CBLL2 "CT138, FLJ25735, HAKAIL, ZNF645" ENSG00000175809 "Cbl proto-oncogene like 2" Q8N7E2 X 22272913-22274461 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 20 "testis: 8.5" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 40: Granulosa cells - Unknown function" 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 CCNB1IP1 "C14orf18, HEI10" ENSG00000100814 "Cyclin B1 interacting protein 1" Q9NPC3 14 20311368-20333312 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Meiosis, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "hTERT-HME1: 381.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 1: Thyroid gland - Transcription" "Cluster 30: Epithelial cell lines - Translation" "Cluster 32: Non-specific - Translation" "unprognostic (4.79e-2)" "unprognostic (1.35e-1)" "unprognostic (1.29e-1)" "unprognostic (9.37e-2)" "unprognostic (5.46e-3)" "unprognostic (2.79e-2)" "unprognostic (8.43e-2)" "unprognostic (5.88e-2)" "unprognostic (1.56e-1)" "unprognostic (1.88e-2)" "unprognostic (4.87e-2)" "unprognostic (4.77e-2)" "prognostic favorable (5.18e-6)" "unprognostic (2.12e-1)" "unprognostic (1.54e-2)" "unprognostic (4.43e-1)" "unprognostic (1.52e-1)" 31.3 20.0 31.7 10.6 32.8 35.5 58.1 31.8 44.3 52.6 38.4 35.3 21.3 43.0 48.4 27.3 53.2 20.8 74.7 31.1 35.3 66.4 74.9 36.9 25.3 34.7 32.7 99.4 45.3 51.3 22.2 31.3 34.9 38.1 30.1 21.2 29.6 24.4 52.2 35.5 24.7 29.9 32.7 20.4 31.0 23.3 31.8 32.0 57.4 63.4 30.7 40.0 41.7 34.4 30.8 24.7 137.5 133.3 68.9 94.1 110.3 37.0 73.6 55.5 72.8 83.2 33.4 106.2 23.9 27.1 55.6 53.8 96.6 69.9 74.3 30.9 82.0 63.1 22.6 79.7 201.7 117.5 56.6 128.8 114.6 39.6 381.3 67.3 42.6 125.7 77.7 82.1 37.0 48.9 68.5 79.3 83.2 66.5 46.6 82.9 67.9 45.5 58.7 44.6 109.0 113.6 25.5 58.5 170.7 75.8 18.7 84.5 18.4 31.6 40.1 38.4 48.8 38.3 51.0 72.6 10.6 97.3 37.1 6.3 4.2 0.1 8.2 1.4 10.9 11.6 9.0 10.3 17.7 9.8 9.2 13.0 0.6 6.0 1.6 18.2 13.3 3.8 31.7 32.8 31.8 44.3 31.1 35.3 34.7 32.7 34.9 32.7 31.8 34.4 22.2 28.9 27.2 16.3 35.5 58.1 74.0 45.5 113.3 4.2 57.0 71.9 30.9 58.6 21.0 23.9 20.9 41.2 27.7 15.1 103.7 31.8 64.2 13.0 37.6 24.9 41.3 34.7 22.2 38.2 70.6 34.5 23.0 20.2 34.9 76.7 20.0 35.3 17.8 1.7 28.5 40.1 28.5 23.3 26.5 92.8 51.6 22.4 51.6 7.5 17.8 46.9 30.9 15.1 19.7 29.3 18.8 44.0 17.4 63.5 21.0 86.5 5.2 17.6 46.0 36.6 31.6 101.0 77.5 67.0 40.1 34.1 28.7 61.1 44.3 51.3 CDC34 "E2-CDC34, UBC3, UBE2R1" ENSG00000099804 "Cell division cycle 34, ubiqiutin conjugating enzyme" P49427 19 531760-542092 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 249.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002382, CAB005109, CAB047311, HPA074334" Approved Supported "Nucleoplasm,Nuclear speckles,Cytosol" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 1: K-562 - Erythropoiesis" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Nuclear speckles" Cytosol "CAB005109: AB_2276050, CAB047311: , HPA002382: AB_1846370, HPA074334: " "unprognostic (4.65e-2)" "unprognostic (2.02e-1)" "unprognostic (1.41e-1)" "unprognostic (8.72e-2)" "unprognostic (2.84e-1)" "unprognostic (5.73e-2)" "prognostic unfavorable (7.57e-4)" "unprognostic (2.20e-1)" "unprognostic (3.11e-1)" "unprognostic (3.83e-2)" "unprognostic (2.09e-2)" "unprognostic (3.06e-2)" "unprognostic (3.02e-2)" "unprognostic (8.87e-3)" "unprognostic (9.68e-2)" "unprognostic (7.82e-3)" "unprognostic (3.33e-2)" 35.1 36.7 52.0 13.3 51.2 34.5 34.2 51.5 63.0 36.9 47.5 62.5 17.8 33.5 14.1 40.5 33.6 10.1 80.0 52.7 48.7 32.1 88.0 32.1 12.5 51.0 50.7 35.6 58.5 18.7 43.4 29.2 50.8 36.9 11.5 28.2 34.2 19.3 105.0 51.8 27.6 18.5 48.2 31.0 38.6 100.2 52.7 16.4 26.7 63.2 9.7 43.7 34.2 52.7 54.8 54.6 66.4 54.7 29.2 28.4 68.5 47.8 36.1 50.2 51.9 86.1 32.8 29.5 49.3 34.1 30.1 36.9 52.1 40.2 25.0 49.2 146.0 27.8 35.5 94.5 73.6 39.0 32.4 36.4 58.9 42.2 43.6 38.8 60.6 41.2 120.3 57.5 33.8 80.7 53.3 53.6 85.3 39.4 51.7 49.1 35.1 51.2 38.0 32.4 87.2 65.9 41.5 42.1 85.2 53.2 34.0 57.4 50.5 36.5 43.7 86.2 65.2 57.7 47.3 40.1 50.0 55.6 38.8 3.2 2.5 4.7 1.6 2.7 1.1 2.3 2.1 2.9 2.0 1.0 1.6 1.6 8.2 1.2 3.5 1.6 2.5 1.0 52.0 51.2 51.5 63.0 52.7 48.7 51.0 50.7 50.8 48.2 52.7 52.7 39.4 0.0 5.4 21.9 11.4 46.8 17.5 5.4 16.5 35.5 43.4 47.1 27.7 27.1 3.5 14.7 25.0 44.3 30.9 47.4 13.7 24.9 63.9 29.6 28.3 27.7 13.2 77.7 8.3 20.5 55.4 21.4 16.8 42.3 0.0 28.1 15.7 41.1 27.9 16.8 6.3 34.0 14.2 14.5 38.6 249.4 18.0 20.6 19.6 2.8 15.1 68.9 20.6 6.6 12.9 45.0 27.0 15.1 25.0 34.8 25.9 18.9 5.5 44.3 13.1 22.6 34.9 22.4 54.6 15.2 54.7 63.1 22.0 27.1 23.7 27.9 CDC42BPA "FLJ23347, KIAA0451, MRCK, MRCKA, PK428" ENSG00000143776 "CDC42 binding protein kinase alpha" Q5VT25 1 226989865-227318474 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 320.3;Excitatory neurons: 447.6;Inhibitory neurons: 479.0;Oligodendrocyte precursor cells: 444.3;Oligodendrocytes: 671.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB070414, HPA071252" Approved Approved "Intermediate filaments" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 78: Testis - Spermatogenesis" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Intermediate filaments" "CAB070414: AB_11156796, HPA071252: AB_2686374" "unprognostic (3.67e-3)" "unprognostic (1.45e-1)" "unprognostic (1.10e-1)" "unprognostic (2.78e-2)" "unprognostic (3.04e-1)" "unprognostic (5.90e-2)" "unprognostic (7.89e-2)" "unprognostic (2.27e-1)" "unprognostic (1.46e-1)" "unprognostic (3.93e-1)" "unprognostic (4.88e-2)" "unprognostic (2.87e-2)" "unprognostic (7.73e-3)" "unprognostic (1.35e-1)" "unprognostic (1.70e-1)" "unprognostic (9.79e-2)" "unprognostic (1.21e-2)" 15.6 12.5 26.3 5.5 32.4 3.5 12.2 33.5 30.0 15.8 12.2 21.2 14.7 15.0 7.7 10.1 12.6 13.7 16.4 24.9 25.2 17.3 14.7 12.3 2.0 25.7 26.8 14.0 13.1 19.7 14.6 12.7 27.0 15.8 10.3 23.7 7.6 14.9 11.4 6.3 12.9 14.5 19.8 6.6 22.4 24.4 29.7 2.2 8.1 13.6 1.8 23.0 11.3 37.0 22.6 21.1 21.9 10.4 21.5 26.4 7.7 25.4 35.7 17.2 17.9 17.1 50.1 0.1 26.6 42.4 13.0 10.3 16.3 14.2 20.9 0.1 13.2 17.4 25.5 6.7 24.3 14.1 7.5 18.6 17.9 27.8 27.8 21.3 58.0 13.6 45.1 0.1 28.2 6.2 0.4 2.5 18.0 29.3 20.0 0.0 37.0 0.1 27.7 43.1 15.7 22.9 43.0 17.8 24.8 13.4 23.1 0.8 59.0 31.3 16.2 36.1 33.9 0.1 0.1 0.1 41.4 0.0 42.7 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 26.3 32.4 33.5 30.0 24.9 25.2 25.7 26.8 27.0 19.8 29.7 37.0 82.6 41.7 35.7 320.3 0.8 11.7 26.0 15.9 12.0 97.7 14.0 12.8 59.9 30.0 38.9 44.1 118.9 5.9 1.8 49.3 13.7 26.0 128.0 18.7 45.1 68.4 26.4 45.6 447.6 41.1 7.3 44.4 92.8 25.7 7.0 21.5 47.8 28.9 3.7 223.8 479.0 30.5 22.4 4.4 9.9 132.3 44.1 6.4 16.0 180.8 5.9 33.4 0.0 444.3 671.8 65.1 74.0 85.4 1.8 30.1 50.7 41.3 24.8 66.9 78.9 64.0 68.4 45.6 57.7 8.0 8.0 1.4 1.3 23.4 34.4 43.1 CDC42BPB "KIAA1124, MRCKB" ENSG00000198752 "CDC42 binding protein kinase beta" Q9Y5S2 14 102932380-103057549 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA022821 Approved NA NA 12000 "Cluster 7: Monocytes - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 44: Endometrium - Transcription" "HPA022821: AB_1846376" "unprognostic (6.73e-2)" "unprognostic (2.19e-2)" "unprognostic (6.99e-2)" "unprognostic (5.67e-2)" "unprognostic (1.41e-2)" "unprognostic (2.19e-1)" "unprognostic (2.90e-2)" "prognostic unfavorable (2.38e-4)" "unprognostic (2.71e-1)" "unprognostic (1.24e-1)" "unprognostic (3.46e-2)" "unprognostic (2.28e-1)" "prognostic favorable (8.67e-10)" "unprognostic (2.11e-1)" "unprognostic (1.86e-1)" "unprognostic (8.59e-2)" "unprognostic (7.56e-2)" 38.7 31.3 42.7 17.8 42.5 3.6 31.2 31.2 40.2 33.5 21.0 35.8 30.2 38.0 17.9 37.8 31.3 29.5 36.3 44.3 36.4 32.3 28.9 32.9 9.8 38.6 40.2 33.4 33.1 34.2 32.5 29.5 35.7 28.7 20.2 24.1 27.9 30.4 27.2 33.0 34.9 32.3 38.5 22.2 32.0 25.2 40.8 8.6 29.6 24.2 12.6 35.0 33.2 46.1 42.8 83.8 52.7 38.7 57.3 65.1 53.0 47.9 50.3 49.7 45.4 28.8 49.0 0.0 51.1 93.7 37.7 53.0 54.9 57.2 52.3 52.2 24.8 23.4 68.0 29.0 62.2 0.2 24.1 56.7 57.6 51.0 48.5 52.2 97.7 9.8 19.3 11.7 48.3 89.2 0.4 5.4 25.3 66.5 68.4 0.2 44.3 1.2 63.1 82.6 38.2 41.6 85.1 31.6 35.8 55.7 48.7 14.9 125.3 47.3 31.6 105.8 45.3 15.1 17.4 12.4 53.2 5.2 46.9 0.0 0.2 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 42.7 42.5 31.2 40.2 44.3 36.4 38.6 40.2 35.7 38.5 40.8 46.1 57.1 57.7 35.8 37.5 7.8 14.5 16.5 14.5 17.6 45.8 19.1 15.4 28.8 28.6 27.4 55.2 33.3 12.6 0.5 35.4 3.9 29.8 14.2 35.8 55.0 46.3 25.2 11.0 40.3 21.8 11.1 25.7 32.1 59.4 13.3 37.8 36.0 20.5 12.8 57.2 33.1 16.1 30.5 13.5 14.7 7.9 32.3 21.7 12.4 31.9 11.1 29.3 0.0 31.7 74.6 44.2 15.4 55.3 3.5 26.1 28.2 15.4 28.1 42.3 6.6 38.6 29.3 15.5 17.0 27.2 18.3 16.8 3.2 37.3 27.5 32.4 CDC42BPG "DMPK2, HSMDPKIN, kappa-200, MRCKgamma" ENSG00000171219 "CDC42 binding protein kinase gamma" Q6DT37 11 64823052-64844653 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skin 1: 33.7" "Cell type enhanced" "Detected in many" "Distal enterocytes: 14.8;Gastric mucus-secreting cells: 23.0;Paneth cells: 18.3;Squamous epithelial cells: 19.3" "Low cancer specificity" "Detected in many" "Region enriched" "Detected in some" 8 "cerebellum: 9.7" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 29.3;HaCaT: 22.5;MCF7: 30.7;RT4: 18.4;SK-BR-3: 18.4;T-47d: 18.1" "Region enriched" "Detected in all" 4 "cerebellum: 10.5" "Low region specificity" "Detected in some" "HPA027382, HPA061836" Enhanced Supported Cytosol NA NA "Cluster 31: Skin - Epidermis development" "Cluster 28: BEWO - Transcription regulation" "Cluster 61: Squamous epithelial cells - Keratinization" Cytosol "HPA027382: AB_1846378, HPA061836: AB_2684622" "unprognostic (3.26e-2)" "unprognostic (1.58e-1)" "unprognostic (6.00e-2)" "unprognostic (2.60e-1)" "unprognostic (1.21e-1)" "unprognostic (2.50e-1)" "unprognostic (4.68e-1)" "unprognostic (5.27e-2)" "unprognostic (3.91e-2)" "unprognostic (3.65e-2)" "unprognostic (1.26e-1)" "unprognostic (1.81e-1)" "prognostic favorable (5.99e-13)" "unprognostic (2.60e-2)" "unprognostic (1.55e-1)" "unprognostic (2.14e-2)" "unprognostic (3.99e-3)" 0.5 4.9 0.2 1.4 0.3 2.1 4.8 9.7 1.2 5.4 5.5 8.8 10.6 0.4 2.0 26.5 3.8 2.8 0.4 0.4 0.3 7.7 0.9 7.8 1.3 0.4 0.7 2.2 14.1 6.4 11.0 4.2 1.0 8.5 4.5 0.3 17.7 3.7 0.2 33.7 9.3 0.2 0.3 1.8 12.2 3.3 0.3 2.4 6.0 0.0 2.0 5.8 13.0 0.3 8.9 1.2 0.8 0.0 0.0 0.0 29.3 0.0 0.0 0.0 0.0 11.7 7.5 0.1 4.3 0.0 0.4 22.5 1.3 8.8 0.0 0.4 3.6 0.7 5.3 3.8 0.0 0.3 2.2 0.0 10.9 0.1 0.1 0.1 0.1 3.5 6.1 0.1 0.0 30.7 0.2 1.7 2.7 8.3 1.3 1.3 0.5 4.3 5.5 18.4 15.6 0.7 2.8 18.4 0.5 4.3 18.1 0.4 0.1 0.0 3.1 0.1 0.1 2.1 2.2 2.2 0.0 0.3 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 9.7 1.2 0.4 0.3 0.4 0.7 1.0 0.3 0.3 0.3 1.0 9.6 7.9 0.0 1.2 6.5 2.3 3.6 9.6 0.0 5.1 5.8 1.8 2.8 9.6 1.8 0.0 6.4 1.7 14.8 0.0 2.4 0.6 13.2 0.7 0.4 3.6 0.8 0.1 6.2 4.9 0.7 23.0 7.9 1.3 0.4 0.0 0.0 1.0 0.0 0.1 4.8 2.0 0.0 0.4 0.8 0.0 1.3 0.0 0.0 1.2 0.8 1.0 0.0 0.1 2.9 18.3 0.0 0.1 1.6 12.4 0.5 9.5 0.0 0.0 2.2 0.8 1.7 1.3 19.3 8.1 6.7 1.4 0.6 5.7 3.4 CDC7 "CDC7L1, HsCdc7, Hsk1, huCdc7" ENSG00000097046 "Cell division cycle 7" O00311 1 91500851-91525764 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 16.9" "Cell type enhanced" "Detected in many" "Early spermatids: 37.8;Erythroid cells: 23.1;Spermatocytes: 30.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002669, HPA035831" Enhanced Supported "Nucleoplasm,Cytokinetic bridge,Mitotic spindle" Yes No "Cluster 20: T-cells - T-cell receptor" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 30: Mammary glandular cells - Lactation" Nucleoplasm "Cytokinetic bridge, Mitotic spindle" "CAB002669: , HPA035831: AB_2674807" "unprognostic (6.84e-2)" "unprognostic (6.01e-2)" "unprognostic (4.64e-2)" "unprognostic (7.02e-3)" "unprognostic (5.57e-2)" "unprognostic (3.57e-3)" "prognostic unfavorable (3.15e-6)" "unprognostic (6.52e-2)" "unprognostic (2.23e-2)" "unprognostic (1.36e-3)" "unprognostic (2.04e-2)" "unprognostic (1.75e-2)" "prognostic unfavorable (1.89e-15)" "unprognostic (9.44e-3)" "unprognostic (2.49e-2)" "unprognostic (1.09e-1)" "unprognostic (5.39e-2)" 1.9 2.7 3.6 6.0 3.8 13.8 2.1 6.3 4.8 2.1 1.6 3.0 3.1 1.8 1.7 3.5 1.3 1.7 1.4 3.8 3.4 4.3 1.5 4.2 9.3 2.9 3.7 2.5 1.6 0.8 4.0 5.9 3.1 1.9 4.6 14.1 1.7 1.4 0.5 5.1 3.7 2.4 2.8 12.1 1.8 16.9 3.2 10.9 1.7 0.5 9.4 2.4 2.3 3.5 32.0 9.4 59.1 17.3 1.4 7.6 18.8 12.0 9.1 22.6 24.3 19.6 10.8 22.5 16.1 7.7 19.8 13.7 39.8 13.5 29.4 36.8 34.3 33.7 27.9 9.5 2.1 37.0 11.9 4.2 4.0 21.0 11.9 4.1 8.9 30.9 44.8 31.4 15.2 11.8 31.5 33.5 48.9 17.2 21.6 38.9 49.5 14.5 10.2 24.0 44.7 18.6 37.5 10.2 21.6 14.3 9.8 18.2 7.3 25.8 22.7 20.6 17.9 11.6 15.6 57.9 9.4 36.0 9.4 0.0 1.0 0.0 3.8 0.7 3.2 0.9 2.8 3.5 2.3 0.9 1.5 3.0 0.1 1.6 0.2 1.4 4.6 1.4 3.6 3.8 6.3 4.8 3.8 3.4 2.9 3.7 3.1 2.8 3.2 3.5 1.9 0.0 1.1 3.3 3.2 5.9 1.2 2.7 3.4 8.2 14.4 1.4 2.1 0.0 1.3 1.8 0.0 8.2 4.1 0.6 3.9 1.5 37.8 1.1 4.9 4.1 0.0 23.1 18.3 2.6 6.3 3.1 2.6 1.9 4.5 15.4 4.2 0.2 2.7 3.3 19.6 1.8 6.1 2.2 2.9 18.7 0.9 1.6 3.6 5.6 2.1 1.6 6.2 16.6 3.1 1.2 1.7 0.7 7.1 0.9 0.5 0.4 2.0 5.1 6.6 1.5 4.1 30.5 21.4 4.3 3.7 2.2 5.3 7.6 3.6 1.0 CDK1 "CDC2, CDC28A" ENSG00000170312 "Cyclin dependent kinase 1" P06493 10 60778331-60794852 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters" "Apoptosis, Biological rhythms, Cell cycle, Cell division, Host-virus interaction, Mitosis" "Host cell receptor for virus entry, Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 53.2;lymphoid tissue: 74.0" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 80.9;Erythroid cells: 209.6;Extravillous trophoblasts: 144.6;Spermatocytes: 110.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "NK-cell: 3.2;T-reg: 3.4" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003387, CAB003799, CAB079974" Enhanced Supported Nucleoplasm,Cytosol NA Yes 51000 "Cluster 15: NK-cells - Transcription" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "Nucleoplasm, Cytosol" "CAB003799: AB_344898, CAB079974: , HPA003387: AB_1846356" "unprognostic (6.34e-2)" "prognostic favorable (8.81e-4)" "unprognostic (1.90e-1)" "unprognostic (6.82e-2)" "unprognostic (6.67e-2)" "unprognostic (3.83e-2)" "prognostic unfavorable (1.10e-6)" "prognostic unfavorable (7.88e-4)" "unprognostic (1.30e-2)" "unprognostic (1.30e-1)" "prognostic unfavorable (4.15e-6)" "unprognostic (1.80e-2)" "prognostic unfavorable (0.00e+0)" "unprognostic (2.27e-1)" "unprognostic (2.75e-1)" "unprognostic (2.13e-1)" "unprognostic (1.60e-1)" 3.8 1.8 0.9 17.0 1.0 53.2 7.4 0.9 1.5 5.2 0.9 17.6 16.3 7.1 12.2 17.5 3.7 4.3 1.4 0.9 1.0 3.1 3.2 4.7 40.6 1.2 1.2 2.3 0.8 2.5 4.1 19.4 1.1 1.7 20.8 1.3 3.2 5.2 1.4 13.2 14.5 8.0 0.9 9.0 10.1 25.1 1.4 74.0 3.6 2.2 47.5 7.1 6.9 1.0 249.9 93.5 241.1 96.0 15.4 23.6 99.0 183.8 132.7 218.8 209.0 218.9 213.7 226.2 69.6 50.6 79.6 149.9 166.2 106.8 225.8 162.3 121.1 119.4 84.4 128.1 2.8 184.5 117.6 4.7 10.4 142.1 137.0 49.6 133.3 146.2 185.1 270.3 246.9 66.3 234.0 131.1 106.6 149.3 193.1 199.7 224.5 111.3 84.3 81.4 112.7 98.7 123.5 184.9 96.3 130.0 199.9 111.5 55.4 92.8 197.9 99.1 255.8 104.9 180.8 205.6 79.9 203.5 117.6 0.0 0.0 0.0 0.3 0.1 0.2 0.5 0.7 1.3 0.3 0.4 0.2 0.7 0.0 3.2 0.1 0.9 3.4 0.9 0.9 1.0 0.9 1.5 0.9 1.0 1.2 1.2 1.1 0.9 1.4 1.0 7.7 0.0 3.2 0.3 7.1 39.8 5.4 29.9 2.8 1.1 5.3 6.1 0.8 0.0 10.2 18.4 0.0 80.9 3.6 8.9 3.9 0.8 18.7 10.8 6.2 10.5 3.0 209.6 0.4 0.0 144.6 13.3 13.3 9.4 0.0 51.5 7.5 1.3 57.2 0.0 0.2 14.6 30.5 20.5 18.1 10.4 2.1 16.5 1.8 1.9 1.0 1.0 3.1 0.0 0.1 0.4 0.7 0.7 32.1 4.3 2.2 3.0 17.6 0.7 0.0 0.5 24.6 110.0 39.6 33.8 18.6 22.0 10.3 2.1 26.6 10.4 CDK10 PISSLRE ENSG00000185324 "Cyclin dependent kinase 10" Q15131 16 89680737-89696354 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cilium biogenesis/degradation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007451, HPA059634, HPA067060" Uncertain Supported "Nucleoplasm,Midbody,Midbody ring" Yes Yes "Cluster 27: Non-specific - Gene expression" "Cluster 18: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 52: Non-specific - Transcription" Nucleoplasm "Midbody, Midbody ring" "HPA007451: AB_2732400, HPA059634: AB_2684090, HPA067060: AB_2685772" "unprognostic (7.89e-2)" "unprognostic (8.08e-2)" "unprognostic (3.74e-3)" "unprognostic (9.87e-2)" "unprognostic (1.76e-1)" "unprognostic (3.44e-2)" "unprognostic (4.53e-1)" "unprognostic (9.06e-2)" "unprognostic (2.99e-1)" "unprognostic (2.13e-1)" "prognostic favorable (2.69e-4)" "unprognostic (2.58e-2)" "unprognostic (2.93e-1)" "unprognostic (3.32e-2)" "unprognostic (1.79e-1)" "unprognostic (6.88e-2)" "prognostic favorable (3.63e-4)" 30.1 38.5 20.2 10.4 20.4 19.5 26.7 20.3 32.8 49.3 22.0 38.2 22.7 25.9 8.7 35.3 36.3 8.6 27.3 21.0 19.5 52.9 77.0 31.0 14.7 18.6 18.7 43.2 49.2 13.5 55.5 12.5 19.6 39.1 11.3 7.6 24.8 7.5 33.8 32.1 36.1 8.2 17.0 37.5 38.5 17.0 18.4 10.8 54.5 4.1 7.0 32.3 36.5 19.1 27.5 17.8 13.9 5.8 5.7 11.0 14.2 22.3 12.6 15.2 4.9 13.1 21.2 23.9 9.8 19.3 9.1 15.5 5.8 30.8 9.3 5.3 14.1 9.7 21.0 1.7 23.4 15.8 17.1 13.3 10.7 9.3 15.3 10.3 27.0 16.1 25.5 3.2 17.7 36.6 19.5 45.0 28.5 29.7 13.1 26.5 19.0 34.1 27.9 21.2 10.1 29.6 28.0 13.0 6.8 15.2 30.3 25.0 24.1 9.1 26.6 10.1 15.4 11.7 6.4 7.5 16.4 25.0 15.5 5.1 14.0 4.2 14.8 19.7 12.8 7.8 13.2 10.7 18.1 9.0 15.1 12.6 1.5 20.4 15.4 12.4 11.6 11.4 20.2 20.4 20.3 32.8 21.0 19.5 18.6 18.7 19.6 17.0 18.4 19.1 28.2 12.8 26.6 35.3 21.2 15.4 24.2 26.9 23.3 17.2 24.5 25.1 6.5 38.6 20.0 27.6 25.0 28.6 26.7 44.8 43.0 28.6 6.1 20.7 21.9 23.0 67.7 15.4 44.5 12.5 19.8 19.6 85.1 16.9 9.5 40.3 21.8 41.1 18.8 18.5 33.3 49.4 26.4 17.4 16.0 8.8 23.9 17.0 19.6 17.8 15.5 8.5 26.8 24.6 20.0 13.6 41.5 12.4 20.8 30.7 58.3 53.7 28.1 32.3 6.6 11.4 16.3 27.3 28.7 22.4 15.5 27.9 22.0 54.8 58.2 22.9 CDK11A "CDC2L2, CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, p58GTA, PITSLRE" ENSG00000008128 "Cyclin dependent kinase 11A" Q9UQ88 1 1702379-1724357 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 124.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 85.3" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "CAB010467, HPA025061, HPA073626" Supported Supported "Nuclear speckles,Cytosol" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 2: Immune cells - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 11: Alveolar cells - Smell perception" "Nuclear speckles" Cytosol "CAB010467: AB_631212, HPA025061: AB_1846407, HPA073626: AB_2686619" "unprognostic (6.25e-2)" "unprognostic (8.32e-2)" "unprognostic (1.47e-2)" "unprognostic (2.74e-1)" "unprognostic (9.32e-3)" "unprognostic (3.54e-2)" "unprognostic (2.25e-3)" "unprognostic (7.97e-2)" "prognostic unfavorable (5.06e-4)" "unprognostic (1.28e-1)" "unprognostic (5.58e-3)" "unprognostic (3.07e-2)" "prognostic unfavorable (1.15e-6)" "unprognostic (1.97e-1)" "unprognostic (5.98e-2)" "unprognostic (1.54e-1)" "unprognostic (3.70e-2)" 17.7 17.0 14.9 24.8 15.3 41.7 17.7 18.7 16.2 22.2 14.9 25.0 29.3 19.4 8.8 15.7 20.6 9.4 13.5 14.3 15.8 15.5 18.6 27.4 23.3 15.9 14.6 20.3 17.2 9.3 18.5 12.5 15.4 20.3 14.7 13.1 16.8 7.8 26.0 19.8 36.7 8.8 12.9 36.7 20.3 21.6 15.1 17.0 20.0 7.6 13.8 17.8 19.1 16.4 26.6 16.3 18.7 16.9 20.5 14.5 13.4 25.4 14.3 18.7 20.1 21.9 30.1 31.8 15.2 10.0 19.8 27.1 14.3 15.0 14.3 25.4 19.4 28.8 42.6 20.4 13.3 29.6 45.9 17.1 10.7 13.5 12.2 20.3 22.2 21.4 35.7 27.4 11.1 15.5 19.0 33.4 18.1 18.4 16.0 27.7 19.0 18.9 12.3 13.0 17.7 22.6 25.0 36.3 37.9 7.6 20.4 19.4 22.7 24.3 18.5 10.9 17.2 38.0 31.1 35.3 9.8 33.1 7.2 64.1 16.7 22.0 14.5 9.0 12.1 19.3 12.4 10.7 5.6 19.5 12.0 9.9 85.3 12.0 11.6 33.3 10.9 3.5 14.9 15.3 18.7 16.2 14.3 15.8 15.9 14.6 15.4 12.9 15.1 16.4 27.7 51.3 59.0 5.9 33.9 14.0 16.0 12.5 22.2 33.0 11.3 10.4 1.0 14.3 38.3 14.7 27.1 16.2 54.1 28.8 9.8 19.7 37.6 18.0 24.2 26.4 9.1 29.0 5.3 15.3 22.6 16.6 52.5 21.8 84.6 18.9 18.5 15.6 12.2 40.4 5.0 29.1 12.2 12.2 26.9 16.3 35.4 28.5 10.6 2.8 25.6 16.1 44.3 4.5 8.7 25.9 51.0 21.4 42.7 16.3 62.0 11.7 34.5 42.4 13.1 21.3 19.1 124.0 93.7 15.3 14.6 30.5 48.1 16.5 23.0 14.3 CDK11B "CDC2L1, CDK11-p110, CDK11-p46, CDK11-p58" ENSG00000248333 "Cyclin dependent kinase 11B" P21127 1 1635225-1659012 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 174.6;Spermatogonia: 176.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "HPA025061, HPA073626" Approved Approved "Nuclear speckles" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 59: Non-specific - Translation" "Cluster 20: HeLa - Mitochondria" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" "Nuclear speckles" "HPA025061: AB_1846407, HPA073626: AB_2686619" "unprognostic (7.52e-3)" "unprognostic (4.85e-2)" "unprognostic (1.14e-1)" "unprognostic (2.02e-2)" "unprognostic (3.75e-2)" "prognostic favorable (1.14e-4)" "unprognostic (9.75e-3)" "unprognostic (1.14e-1)" "unprognostic (1.88e-1)" "unprognostic (1.48e-1)" "unprognostic (2.18e-1)" "unprognostic (1.14e-2)" "unprognostic (6.04e-2)" "unprognostic (8.45e-2)" "unprognostic (1.27e-1)" "unprognostic (7.19e-2)" "unprognostic (6.52e-3)" 31.8 29.0 20.6 17.6 20.8 43.0 30.0 18.1 20.9 32.4 16.6 46.1 25.6 35.9 5.8 30.3 31.6 9.9 39.6 18.3 20.2 28.2 32.1 41.0 19.5 21.2 19.8 33.4 35.0 8.9 30.5 10.6 20.7 31.7 9.4 9.0 28.4 12.7 85.9 39.3 44.6 10.4 20.4 47.7 34.5 49.8 20.8 13.2 30.8 17.8 10.6 37.9 30.8 21.6 47.2 36.4 21.9 17.4 17.8 12.0 30.6 43.7 18.8 24.0 20.8 41.3 43.7 40.8 43.9 18.7 16.9 35.4 18.6 22.0 18.4 36.3 40.4 43.9 68.9 36.1 24.1 50.4 44.3 16.1 15.8 26.2 19.9 14.1 24.5 42.3 51.9 26.9 14.4 31.0 47.9 42.5 38.9 13.8 43.7 46.9 43.4 33.5 12.7 16.6 28.3 36.4 40.3 36.7 42.3 15.0 25.2 33.4 37.4 29.8 33.0 22.7 43.0 60.5 58.7 85.6 37.4 55.9 23.2 7.2 3.3 5.3 6.1 2.8 2.7 3.3 3.8 3.6 2.8 3.7 4.1 3.1 13.8 4.4 3.2 5.1 3.2 1.6 20.6 20.8 18.1 20.9 18.3 20.2 21.2 19.8 20.7 20.4 20.8 21.6 35.2 19.2 43.1 13.7 42.9 14.4 19.5 10.2 25.6 32.0 22.2 18.3 42.9 30.0 31.7 27.6 20.9 27.7 44.7 86.6 9.8 33.3 39.7 28.1 34.2 32.3 28.8 25.0 14.1 35.2 31.5 25.1 48.9 36.3 55.6 24.1 25.7 38.6 20.5 15.2 12.3 73.8 10.2 30.1 14.5 25.6 28.9 33.9 5.4 15.0 36.3 20.5 76.2 10.1 18.2 37.4 93.3 26.7 54.7 19.6 95.4 19.2 29.4 42.4 52.6 25.9 31.0 174.6 176.5 27.5 17.3 44.6 48.9 16.5 56.9 15.9 CDK12 "CRK7, CRKR, CRKRS, KIAA0904" ENSG00000167258 "Cyclin dependent kinase 12" Q9NYV4 17 39461486-39564907 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "mRNA processing, mRNA splicing" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SK-BR-3: 307.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008038, HPA073305" Supported Enhanced "Nucleoplasm,Nuclear speckles" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Nuclear speckles" "HPA008038: AB_1078570, HPA073305: " "unprognostic (2.02e-1)" "unprognostic (1.80e-1)" "unprognostic (2.61e-2)" "unprognostic (7.56e-2)" "unprognostic (1.05e-1)" "unprognostic (3.19e-1)" "unprognostic (2.56e-3)" "unprognostic (2.37e-2)" "unprognostic (3.86e-2)" "unprognostic (3.00e-3)" "unprognostic (6.87e-3)" "unprognostic (1.86e-1)" "unprognostic (3.06e-2)" "unprognostic (9.10e-2)" "unprognostic (1.24e-1)" "unprognostic (2.22e-2)" "unprognostic (5.32e-1)" 9.5 7.6 2.5 14.0 1.9 34.3 9.5 8.0 4.0 11.0 4.1 9.8 9.9 10.8 6.0 10.4 9.2 9.2 6.8 1.6 2.9 8.0 12.3 9.2 15.1 3.0 1.7 11.9 8.7 13.0 6.2 11.5 1.6 9.8 10.4 11.7 9.2 9.3 6.7 10.6 10.4 10.0 0.3 12.9 10.3 17.7 3.4 17.9 12.2 7.8 15.3 13.1 9.1 3.3 31.9 40.0 24.9 22.2 17.2 19.0 21.1 28.9 24.7 39.9 29.0 48.1 19.8 45.4 24.6 31.1 38.7 51.8 49.2 36.6 38.4 29.6 38.7 49.7 26.9 36.3 16.4 66.9 33.4 20.4 25.0 48.2 37.6 16.0 24.4 27.7 85.2 30.7 22.9 14.3 57.9 17.7 23.8 16.0 16.9 36.8 50.3 25.7 14.8 38.8 24.6 15.7 37.0 307.8 25.1 34.8 38.5 29.3 26.4 34.5 27.6 24.5 37.9 23.6 18.4 63.5 24.2 28.2 23.0 11.2 2.0 3.2 2.6 1.5 1.8 1.8 1.5 1.7 1.2 3.1 1.7 1.6 7.0 4.5 1.3 2.7 1.2 0.7 2.5 1.9 8.0 4.0 1.6 2.9 3.0 1.7 1.6 0.3 3.4 3.3 41.4 25.6 29.1 50.9 59.0 64.6 58.5 31.2 50.1 46.6 38.1 26.9 14.5 32.9 40.3 38.6 64.6 33.2 59.0 44.6 13.7 30.2 25.1 49.8 63.4 40.6 31.1 39.3 53.9 27.5 29.9 39.2 45.3 63.1 29.1 43.8 32.2 46.3 27.4 35.3 52.9 39.6 42.7 45.9 49.1 17.3 37.3 41.3 26.6 32.8 41.4 27.8 48.4 47.3 53.1 47.9 33.9 33.8 53.5 81.5 33.3 16.7 38.1 65.4 32.9 48.0 48.5 140.2 104.8 53.0 69.0 58.3 59.0 46.0 39.9 84.8 CDK13 "CDC2L, CDC2L5, CHED, KIAA1791" ENSG00000065883 "Cyclin dependent kinase 13" Q14004 7 39950121-40099580 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Host-virus interaction, mRNA processing, mRNA splicing" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 179.0;Oligodendrocyte precursor cells: 171.9;Oligodendrocytes: 199.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA059241 Uncertain Supported "Nuclear speckles,Golgi apparatus,Cytosol" NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 34: Non-specific - Transcription" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 52: Non-specific - Transcription" "Nuclear speckles" "Golgi apparatus, Cytosol" "HPA059241: AB_2683956" "unprognostic (1.99e-1)" "unprognostic (1.22e-2)" "unprognostic (2.67e-1)" "unprognostic (2.72e-1)" "unprognostic (1.83e-1)" "unprognostic (1.02e-1)" "unprognostic (4.18e-3)" "unprognostic (3.42e-2)" "unprognostic (8.09e-2)" "unprognostic (1.13e-2)" "unprognostic (3.77e-2)" "unprognostic (8.13e-2)" "unprognostic (8.20e-2)" "unprognostic (1.21e-1)" "unprognostic (3.33e-2)" "unprognostic (3.53e-1)" "unprognostic (3.53e-2)" 11.4 10.2 8.8 14.6 10.8 28.1 11.1 19.3 9.9 12.8 6.7 11.9 10.5 13.6 14.2 14.7 15.0 12.7 10.4 8.1 10.7 12.7 15.9 12.1 21.7 10.5 8.5 20.1 12.8 17.2 8.0 13.6 8.6 11.2 13.6 19.7 12.9 11.8 11.2 12.0 12.0 12.0 7.2 16.6 12.3 19.0 10.1 19.6 20.6 14.0 20.2 13.4 10.0 14.9 28.4 16.6 28.2 27.0 24.9 24.1 19.3 22.1 23.8 19.8 24.6 17.8 19.1 51.0 12.6 23.4 34.8 33.6 23.4 19.4 29.0 25.3 17.3 22.8 20.0 16.0 23.7 34.8 23.5 14.3 25.5 22.6 30.0 22.6 23.6 23.1 39.0 34.3 20.7 14.7 28.0 24.9 40.8 20.0 19.1 30.5 18.5 20.5 18.5 28.1 20.0 28.8 27.6 59.8 19.9 36.7 24.6 43.0 28.3 27.0 26.0 17.6 30.5 28.3 26.0 41.2 19.8 30.9 35.4 7.8 2.2 4.0 4.1 1.9 2.8 6.4 3.8 3.0 1.3 10.5 3.8 3.9 5.9 4.3 3.1 3.3 3.9 1.3 8.8 10.8 19.3 9.9 8.1 10.7 10.5 8.5 8.6 7.2 10.1 14.9 47.6 44.8 72.0 131.6 49.7 21.4 18.5 15.9 29.0 47.8 36.7 27.7 30.9 25.8 37.1 31.3 70.9 13.7 91.0 23.1 7.9 20.4 13.9 54.3 51.4 30.9 18.7 5.9 179.0 15.4 9.1 31.7 30.1 72.6 17.1 95.5 19.2 23.7 13.2 37.0 166.2 17.6 14.2 23.8 17.4 9.2 26.1 31.6 14.2 145.2 27.9 22.4 53.5 171.9 199.6 28.6 12.9 17.7 50.1 21.8 15.2 12.7 32.8 69.4 6.6 38.5 32.0 36.1 33.4 34.7 26.1 12.2 49.7 56.8 20.1 25.0 CDK14 "PFTAIRE1, PFTK1" ENSG00000058091 "Cyclin dependent kinase 14" O94921 7 90466424-91210590 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 545.4;Horizontal cells: 173.3;Inhibitory neurons: 426.8;Oligodendrocyte precursor cells: 320.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 8 "basophil: 9.0;memory B-cell: 8.5;naive B-cell: 4.8;neutrophil: 4.8" "Group enriched" "Detected in many" 10 "B-cells: 8.5;granulocytes: 9.0" "Cell line enhanced" "Detected in many" "Karpas-707: 78.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015267 Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 6: Brain - Smell perception" "Cluster 2: Karpas-707 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Cytosol" "HPA015267: AB_1855249" "prognostic favorable (5.86e-4)" "unprognostic (3.96e-1)" "unprognostic (1.91e-2)" "unprognostic (2.09e-3)" "unprognostic (1.18e-1)" "unprognostic (3.45e-1)" "unprognostic (1.72e-1)" "unprognostic (4.48e-2)" "unprognostic (3.60e-2)" "unprognostic (3.09e-2)" "unprognostic (2.77e-3)" "unprognostic (2.91e-2)" "unprognostic (2.57e-2)" "prognostic unfavorable (7.79e-4)" "unprognostic (2.46e-1)" "unprognostic (2.86e-1)" "unprognostic (4.39e-3)" 10.1 4.4 9.7 7.8 12.8 7.1 8.6 11.6 31.2 10.1 0.0 5.9 2.7 8.5 3.1 3.1 12.2 12.2 11.9 18.5 7.9 20.7 13.4 9.6 12.4 7.8 17.9 14.5 15.1 3.0 9.2 6.1 7.8 11.2 3.3 17.4 8.3 6.7 4.6 2.5 3.8 7.6 6.4 8.2 8.0 7.9 19.2 5.5 13.3 7.2 12.9 5.7 5.2 20.5 18.0 0.2 35.0 4.5 31.9 32.0 8.0 14.7 14.0 8.8 9.5 0.4 8.6 58.9 1.8 14.6 13.1 5.2 1.8 20.7 16.9 0.1 8.3 0.0 11.2 0.4 14.7 18.3 0.3 22.7 5.3 26.5 9.4 14.7 11.6 0.4 0.3 78.4 18.4 0.1 0.1 7.3 21.8 0.1 9.6 49.3 47.4 50.2 4.6 4.9 7.7 21.9 37.3 0.2 0.7 15.4 4.7 9.2 28.4 37.8 48.5 32.1 23.0 43.1 36.3 41.9 14.6 23.8 37.9 9.0 0.3 0.5 0.0 0.6 0.0 8.5 0.0 0.0 0.8 4.8 0.0 0.0 4.8 0.1 0.5 0.1 0.2 0.5 9.7 12.8 11.6 31.2 18.5 7.9 7.8 17.9 7.8 6.4 19.2 20.5 11.0 19.2 5.1 118.2 37.4 0.8 7.7 6.0 2.2 6.9 7.0 8.9 18.3 12.8 9.1 11.0 0.0 0.2 0.2 0.4 7.9 9.8 53.9 1.7 13.4 2.8 1.8 4.0 545.4 6.7 0.1 16.1 4.1 1.5 0.0 11.2 1.4 11.3 3.7 173.3 426.8 0.3 4.1 3.4 4.9 46.4 15.5 7.0 5.4 66.5 1.7 9.4 0.0 320.7 32.9 13.4 1.3 15.8 78.1 12.8 0.1 22.7 3.9 9.7 0.0 6.3 15.9 5.4 6.6 1.2 1.3 0.0 1.9 6.5 0.3 4.2 CDK15 "ALS2CR7, PFTAIRE2, PFTK2" ENSG00000138395 "Cyclin dependent kinase 15" Q96Q40 2 201790461-201895550 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "epididymis: 15.2;ovary: 6.1" "Group enriched" "Detected in some" 13 "Early spermatids: 27.1;granulocytes: 79.1;Late spermatids: 40.3" "Not detected" "Not detected" "Region enriched" "Detected in single" 4 "cerebellum: 2.4" "Group enriched" "Detected in some" 28 "basophil: 1.8;eosinophil: 3.7" "Lineage enriched" "Detected in single" 37 "granulocytes: 3.7" "Cell line enhanced" "Detected in some" "BJ hTERT+: 22.6;BJ hTERT+ SV40 Large T+ RasG12V: 20.7;HBF TERT88: 30.9;HMC-1: 58.4;LHCN-M2: 19.1" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA015786 Uncertain Approved "Nucleoplasm,Golgi apparatus" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 68: Epididymis - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 60: Granulocytes - Receptor signaling" Nucleoplasm "Golgi apparatus" "HPA015786: AB_1844780" "unprognostic (2.51e-1)" "unprognostic (2.73e-1)" "unprognostic (2.84e-2)" "unprognostic (1.30e-2)" "unprognostic (1.42e-1)" "unprognostic (2.94e-1)" "unprognostic (4.79e-2)" "unprognostic (1.07e-1)" "unprognostic (1.52e-1)" "unprognostic (1.52e-2)" "unprognostic (1.64e-2)" "unprognostic (1.80e-2)" "unprognostic (7.38e-2)" "unprognostic (9.99e-5)" "unprognostic (6.31e-2)" "unprognostic (1.48e-2)" "unprognostic (1.05e-2)" 0.7 0.3 0.0 0.2 0.0 0.0 0.8 2.4 0.4 0.8 0.0 0.5 0.3 0.6 15.2 0.6 0.5 1.9 0.2 0.5 0.0 0.3 0.0 1.0 0.1 0.4 0.1 6.1 0.1 0.2 0.3 0.0 0.4 0.7 0.7 0.0 0.3 0.3 0.9 0.6 0.8 0.4 0.1 0.0 0.7 1.9 0.1 0.2 0.1 0.7 0.1 0.8 0.5 0.3 0.3 0.0 0.0 0.0 1.6 2.8 0.0 5.9 22.6 10.2 20.7 0.0 3.0 0.0 0.0 2.3 0.5 0.0 0.0 0.0 30.9 0.0 0.1 1.9 0.0 0.0 0.3 0.1 58.4 3.4 0.0 2.7 1.5 0.4 0.0 0.0 0.0 0.1 19.1 0.0 0.0 0.7 0.1 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.2 0.5 2.5 0.1 0.0 0.0 0.0 0.3 0.0 0.0 1.8 0.0 3.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.4 0.5 0.0 0.4 0.1 0.4 0.1 0.1 0.3 0.1 0.0 1.3 0.3 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 27.1 0.0 0.0 0.1 0.0 0.0 2.4 0.0 0.0 0.8 0.0 0.0 79.1 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.3 40.3 0.3 0.1 3.6 1.0 0.0 0.0 0.0 1.0 0.3 0.0 0.0 0.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.4 0.5 0.2 0.0 0.1 0.0 0.9 0.1 0.0 0.0 CDK16 "FLJ16665, PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1" ENSG00000102225 "Cyclin dependent kinase 16" Q00536 X 47217860-47229997 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Differentiation, Spermatogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 217.6" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000974, HPA001366, CAB016535" Approved Approved "Plasma membrane,Microtubules,Cytosol" NA NA "Cluster 24: B-cells - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 31: Spermatids - Spermatogenesis" "Microtubules, Cytosol" "Plasma membrane" "CAB016535: AB_785112, HPA000974: AB_2666162, HPA001366: AB_1079584" "unprognostic (2.37e-3)" "unprognostic (6.93e-2)" "unprognostic (2.96e-2)" "unprognostic (1.16e-3)" "unprognostic (8.80e-2)" "unprognostic (2.92e-2)" "prognostic unfavorable (2.02e-6)" "unprognostic (2.85e-1)" "unprognostic (5.59e-2)" "unprognostic (7.62e-3)" "unprognostic (1.20e-1)" "unprognostic (1.09e-1)" "unprognostic (1.46e-1)" "unprognostic (1.59e-2)" "unprognostic (1.83e-1)" "unprognostic (3.89e-3)" "unprognostic (2.55e-1)" 48.2 61.3 59.0 30.4 63.6 65.7 38.6 63.8 75.0 37.9 35.7 41.4 34.2 37.5 19.7 60.7 37.6 23.8 113.3 64.3 46.5 62.7 35.0 41.6 24.3 57.2 52.4 45.3 43.1 50.6 41.7 37.9 54.9 37.2 29.6 33.6 43.9 30.4 217.6 41.9 36.3 37.7 39.6 34.0 39.1 55.2 74.3 29.9 50.3 180.4 26.5 34.2 36.8 60.6 177.6 132.5 124.8 185.0 89.5 76.2 124.2 82.4 100.7 122.3 90.5 150.2 83.3 42.1 51.2 148.1 225.7 97.7 134.3 174.7 81.8 50.9 212.6 46.0 193.8 118.8 115.7 48.7 103.0 95.5 109.6 173.8 207.4 101.7 111.0 43.7 69.6 69.7 108.4 153.1 42.7 111.1 97.9 66.3 141.8 44.9 98.8 74.4 91.7 137.7 105.0 79.4 223.2 169.9 86.5 144.4 152.0 59.3 112.9 81.1 131.4 125.4 99.8 54.6 58.2 41.8 71.4 223.0 93.1 2.6 7.8 7.5 3.7 9.3 4.9 3.4 5.0 6.0 9.7 9.8 4.3 4.6 3.2 5.5 8.4 11.3 5.5 6.1 59.0 63.6 63.8 75.0 64.3 46.5 57.2 52.4 54.9 39.6 74.3 60.6 18.8 0.0 6.1 7.2 20.2 32.5 33.0 30.6 33.6 23.5 38.2 26.8 43.3 21.5 22.1 31.3 4.2 25.7 20.1 67.2 54.8 33.7 26.5 41.2 24.5 21.8 28.1 20.6 12.5 37.0 45.2 24.0 46.4 57.7 5.7 27.8 19.2 16.7 25.3 30.3 15.8 34.3 32.6 19.5 30.8 94.8 17.1 23.5 33.8 2.8 12.6 17.1 9.2 3.5 7.8 48.4 46.1 13.2 31.9 48.3 45.1 34.7 17.9 14.6 0.0 19.1 22.6 27.6 17.5 64.2 34.7 26.0 21.5 30.0 48.6 63.3 CDK17 "PCTAIRE2, PCTK2" ENSG00000059758 "Cyclin dependent kinase 17" Q00537 12 96278261-96400480 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 101.5;Oligodendrocytes: 259.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HUVEC TERT2: 134.8;TIME: 160.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015325 Approved Approved Nucleoplasm,Cytosol Yes No "Cluster 38: Basophils - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 59: Non-specific - Transcription" "Nucleoplasm, Cytosol" "HPA015325: AB_1855090" "unprognostic (4.35e-1)" "unprognostic (2.79e-1)" "unprognostic (2.70e-1)" "unprognostic (3.56e-1)" "unprognostic (1.50e-1)" "unprognostic (4.96e-3)" "unprognostic (5.22e-3)" "unprognostic (1.23e-1)" "unprognostic (3.23e-2)" "unprognostic (2.75e-2)" "unprognostic (2.44e-1)" "unprognostic (5.96e-2)" "prognostic unfavorable (1.09e-6)" "unprognostic (4.97e-3)" "unprognostic (1.72e-1)" "unprognostic (2.92e-2)" "unprognostic (1.70e-2)" 21.4 11.2 26.3 18.9 45.9 48.1 18.4 23.0 34.7 13.2 8.3 17.0 11.9 26.2 9.1 14.6 13.9 16.2 11.4 36.7 28.6 11.6 16.3 20.6 21.7 23.2 23.0 15.7 10.5 10.6 8.0 31.8 23.0 14.0 12.2 19.3 8.7 11.1 8.8 11.0 11.5 29.5 27.4 21.8 10.5 26.6 28.5 24.8 11.6 12.3 22.2 17.1 12.8 54.0 15.4 12.5 32.5 8.9 15.9 41.2 24.1 34.8 46.9 29.1 27.2 7.7 8.8 22.7 23.0 24.5 15.6 13.8 19.8 20.9 39.5 24.9 15.5 32.7 8.5 10.9 34.4 17.9 18.4 30.0 21.3 43.0 77.1 51.8 134.8 18.9 24.7 18.1 66.8 9.5 17.0 28.1 14.4 7.6 22.8 29.2 18.0 19.8 35.1 12.7 17.1 11.7 19.9 18.4 25.9 24.7 14.0 15.7 160.5 25.6 10.0 13.8 18.7 26.0 21.1 24.1 9.6 7.6 19.2 66.7 6.4 17.1 22.2 9.3 24.0 17.5 17.9 25.1 10.0 16.6 25.0 21.7 23.2 31.4 9.0 7.3 15.8 16.6 26.3 45.9 23.0 34.7 36.7 28.6 23.2 23.0 23.0 27.4 28.5 54.0 58.1 16.0 6.5 54.5 37.3 26.8 10.7 8.6 19.4 11.8 13.8 9.8 11.9 7.2 10.3 9.2 16.7 12.0 64.4 7.2 0.0 4.9 3.3 17.6 10.0 51.7 15.0 17.9 101.5 3.6 27.9 24.0 21.4 17.2 18.3 8.9 34.2 10.8 12.1 5.0 59.2 7.9 4.1 14.5 20.7 4.1 9.9 16.7 17.8 64.6 8.6 22.6 32.0 52.3 259.2 7.4 3.4 9.4 64.7 12.5 6.5 8.6 15.4 9.6 6.6 22.7 22.0 8.8 21.6 24.2 25.9 13.7 63.2 10.7 6.0 15.1 CDK18 "PCTAIRE3, PCTK3" ENSG00000117266 "Cyclin dependent kinase 18" Q07002 1 205504596-205532793 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 179.6;heart muscle: 116.3" "Cell type enriched" "Detected in many" 4 "Oligodendrocytes: 462.9" "Cancer enhanced" "Detected in all" "renal cancer: 32.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HBEC3-KT: 38.5;HeLa: 35.3;hTERT-RPE1: 32.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045429 Approved Approved "Actin filaments" No No "Cluster 73: Brain - Neuropeptide signaling" "Cluster 20: HeLa - Mitochondria" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Actin filaments" "HPA045429: AB_10961257" "unprognostic (7.95e-2)" "unprognostic (3.42e-1)" "unprognostic (1.51e-1)" "unprognostic (1.33e-1)" "unprognostic (4.38e-2)" "unprognostic (1.30e-1)" "unprognostic (7.06e-3)" "unprognostic (2.93e-1)" "unprognostic (2.95e-1)" "unprognostic (1.13e-1)" "unprognostic (8.89e-2)" "unprognostic (2.81e-1)" "prognostic unfavorable (5.07e-6)" "unprognostic (6.07e-2)" "unprognostic (1.45e-1)" "unprognostic (6.12e-2)" "prognostic favorable (2.81e-5)" 6.1 9.0 68.6 4.1 131.1 1.1 5.1 141.2 82.6 10.9 40.0 13.1 28.8 8.6 3.4 5.7 8.6 10.4 116.3 57.8 90.8 26.5 10.6 11.0 2.8 179.2 148.1 12.6 16.9 7.8 11.5 16.1 147.7 9.2 9.2 13.3 29.2 23.6 6.1 3.3 24.9 7.0 115.2 9.5 35.8 1.6 122.1 3.6 9.5 5.3 3.7 5.7 7.5 179.6 22.2 1.4 0.2 1.3 0.0 0.0 22.6 0.4 4.1 1.0 5.5 9.4 17.8 12.4 3.2 0.2 1.9 21.2 4.9 38.5 0.9 3.4 3.8 3.0 35.3 10.5 4.0 0.1 0.2 2.5 1.9 0.1 0.8 32.2 0.0 18.4 0.1 15.2 0.3 17.7 1.2 0.6 18.4 6.1 0.9 1.6 0.1 16.6 3.6 13.5 7.9 2.8 6.4 3.2 14.2 24.5 15.3 6.2 0.0 0.0 8.1 0.1 0.1 4.1 2.1 2.5 0.2 9.4 3.7 0.0 0.1 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 68.6 131.1 141.2 82.6 57.8 90.8 179.2 148.1 147.7 115.2 122.1 179.6 4.6 0.0 0.5 12.4 1.0 3.4 6.9 17.4 11.4 7.0 4.6 5.6 29.6 5.7 6.8 73.5 0.0 5.7 0.2 12.1 7.9 18.5 2.4 2.1 0.7 2.9 6.0 1.3 12.0 6.7 2.3 3.8 15.8 4.6 0.0 13.3 2.5 3.7 5.3 0.0 4.5 12.9 2.0 3.8 4.5 4.0 0.9 3.8 3.6 12.2 4.4 28.2 1.0 4.5 462.9 6.5 111.2 1.5 0.9 10.8 35.6 18.7 3.3 1.2 6.6 5.8 12.8 6.6 17.0 5.3 1.3 1.9 1.4 22.7 13.7 9.2 CDK19 "bA346C16.3, CDC2L6, CDK11, KIAA1028" ENSG00000155111 "Cyclin dependent kinase 19" Q9BWU1 6 110609978-110815958 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 40.8" "Cell type enhanced" "Detected in all" "Late spermatids: 137.1;Oligodendrocyte precursor cells: 154.8;Oligodendrocytes: 476.3" "Cancer enhanced" "Detected in all" "prostate cancer: 23.3" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 4.6" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007053, HPA007062" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 18: U-2197 - ECM organization" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol Nucleoplasm "HPA007053: AB_1233803, HPA007062: " "unprognostic (1.66e-2)" "unprognostic (1.84e-1)" "unprognostic (3.63e-1)" "unprognostic (3.00e-3)" "unprognostic (1.62e-1)" "unprognostic (2.66e-3)" "prognostic unfavorable (3.56e-4)" "unprognostic (1.47e-2)" "unprognostic (2.96e-2)" "unprognostic (2.00e-3)" "unprognostic (3.94e-1)" "unprognostic (4.04e-1)" "prognostic unfavorable (4.72e-5)" "unprognostic (1.75e-1)" "unprognostic (9.78e-2)" "unprognostic (6.51e-2)" "unprognostic (9.50e-3)" 6.2 3.4 22.7 7.2 32.1 11.7 6.4 17.9 29.0 6.6 7.5 6.9 5.3 10.2 3.8 8.2 5.4 8.3 4.4 20.8 19.3 6.4 5.0 6.7 9.4 28.8 24.7 9.8 3.9 6.5 2.3 11.5 22.7 26.7 6.4 8.8 4.4 5.9 3.3 8.5 6.7 7.3 19.4 8.0 7.1 18.5 26.9 13.6 6.1 5.4 9.2 5.3 6.6 40.8 5.7 6.1 21.8 26.4 11.1 15.6 10.8 18.8 19.4 6.7 8.8 7.6 6.4 14.7 6.5 13.2 13.9 3.2 8.0 3.9 15.4 18.2 4.5 26.0 8.8 8.9 6.8 10.5 18.2 10.7 8.6 9.7 14.1 17.0 6.8 12.3 7.6 20.2 14.5 9.7 14.3 15.0 2.0 8.1 4.1 14.8 11.3 5.8 7.8 11.0 10.6 19.8 14.4 11.3 17.0 7.2 3.9 37.1 7.7 14.2 7.6 29.6 11.4 2.1 3.2 12.8 15.6 13.7 14.9 2.1 1.2 0.9 0.4 0.7 0.4 0.6 0.3 0.3 1.0 0.6 0.2 0.3 4.6 0.7 0.4 0.5 0.4 0.3 22.7 32.1 17.9 29.0 20.8 19.3 28.8 24.7 22.7 19.4 26.9 40.8 15.9 3.2 17.8 50.6 19.2 9.8 14.4 6.7 12.0 19.2 14.6 9.4 8.2 18.6 8.7 16.5 16.7 7.0 17.8 27.0 1.9 10.5 102.3 13.7 16.5 13.6 12.6 21.6 85.3 4.7 18.4 12.0 13.7 25.6 7.0 23.0 20.0 12.2 16.4 23.5 51.5 13.5 8.2 33.9 19.9 137.1 10.8 22.1 26.6 62.8 19.6 33.9 22.6 154.8 476.3 7.0 20.0 16.1 5.9 30.0 16.1 7.7 6.9 13.9 6.6 11.2 12.3 56.6 15.8 20.3 16.2 7.9 13.3 10.1 13.8 11.1 CDK2 ENSG00000123374 "Cyclin dependent kinase 2" P24941 12 55966781-55972789 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, DNA damage, DNA repair, Meiosis, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 92.8;Extravillous trophoblasts: 84.7;Melanocytes: 87.2;Syncytiotrophoblasts: 170.7" "Cancer enhanced" "Detected in all" "melanoma: 88.3" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SK-MEL-30: 540.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013115, HPA066915" Enhanced Enhanced Nucleoplasm,Centrosome,Cytosol NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 28: Placenta - Pregnancy" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Nucleoplasm "Centrosome, Cytosol" "CAB013115: AB_2536375, HPA066915: AB_2685748" "unprognostic (2.36e-2)" "unprognostic (2.60e-1)" "unprognostic (3.71e-2)" "unprognostic (1.83e-2)" "unprognostic (1.75e-1)" "prognostic unfavorable (9.94e-4)" "prognostic unfavorable (8.61e-5)" "unprognostic (3.48e-2)" "unprognostic (1.31e-1)" "unprognostic (4.67e-2)" "unprognostic (5.38e-3)" "unprognostic (4.69e-3)" "prognostic unfavorable (1.46e-10)" "unprognostic (1.05e-1)" "unprognostic (1.76e-1)" "unprognostic (6.16e-2)" "unprognostic (6.75e-2)" 15.3 9.2 3.5 16.3 3.4 36.0 14.2 3.6 4.9 13.4 6.4 12.5 9.8 13.7 6.3 14.9 13.7 10.8 10.9 3.5 3.8 14.7 16.2 22.9 21.6 4.7 4.0 16.3 10.0 7.9 4.9 47.3 4.1 12.6 14.9 6.5 10.9 14.3 7.0 22.7 12.3 19.5 4.2 14.5 12.2 6.6 4.1 37.2 9.6 8.1 24.8 18.1 12.9 3.9 81.7 39.1 93.6 52.4 19.2 24.9 172.2 98.9 53.5 123.3 114.8 89.4 76.3 77.5 70.9 37.9 46.4 50.8 73.4 44.9 126.8 86.9 68.0 89.0 65.0 34.6 6.3 70.4 61.4 12.6 10.9 83.8 29.1 36.1 63.1 76.8 85.6 68.0 88.3 60.8 149.9 61.7 36.9 55.8 60.7 143.7 86.2 57.1 36.5 77.1 37.4 48.1 114.1 41.7 540.3 54.9 88.9 51.1 34.5 82.9 76.3 65.0 71.0 37.4 46.3 95.5 47.4 51.1 74.2 3.6 2.6 2.2 4.7 2.7 4.6 6.5 2.1 3.5 1.9 3.7 2.0 3.7 1.2 3.4 1.2 7.9 5.4 3.3 3.5 3.4 3.6 4.9 3.5 3.8 4.7 4.0 4.1 4.2 4.1 3.9 17.9 16.0 4.8 1.3 7.3 28.0 23.9 6.2 12.5 0.0 14.5 8.9 3.1 11.5 7.6 1.8 0.0 92.8 7.1 3.7 1.9 11.5 0.6 7.4 6.5 18.2 5.4 14.7 0.1 5.7 84.7 15.7 9.2 13.0 10.8 12.0 10.4 9.1 13.3 1.7 0.1 7.2 6.1 4.7 43.8 0.8 14.9 4.9 87.2 1.9 28.4 4.2 5.2 0.0 0.5 12.3 1.5 4.5 11.8 13.4 2.8 4.5 4.4 3.6 0.0 10.1 11.6 3.1 7.4 14.5 31.4 170.7 9.6 4.8 9.7 19.3 CDK20 "CCRK, p42" ENSG00000156345 "Cyclin dependent kinase 20" Q8IZL9 9 87966441-87974753 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Respiratory ciliated cells: 21.9;Spermatocytes: 30.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "NK-cell: 3.6" "Group enriched" "Detected in many" 7 "NK-cells: 3.6;T-cells: 2.3" "Cell line enhanced" "Detected in many" "SCLC-21H: 18.2;THP-1: 29.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA007666, HPA027379, HPA027401" Enhanced Supported Nucleoplasm NA NA "Cluster 15: NK-cells - Transcription" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 43: THP-1 - Innate immune response" "Cluster 49: Ciliated cells - Cilium organization" Nucleoplasm "HPA007666: AB_10600002, HPA027379: AB_10599939, HPA027401: AB_10601553" "unprognostic (4.60e-2)" "unprognostic (6.48e-2)" "unprognostic (1.69e-2)" "prognostic favorable (2.59e-4)" "unprognostic (2.32e-1)" "unprognostic (4.33e-3)" "unprognostic (2.81e-4)" "unprognostic (6.33e-2)" "unprognostic (1.45e-1)" "unprognostic (1.34e-1)" "unprognostic (2.83e-3)" "unprognostic (4.04e-2)" "prognostic favorable (2.12e-5)" "unprognostic (8.24e-3)" "unprognostic (5.77e-2)" "unprognostic (3.83e-2)" "unprognostic (1.42e-2)" 2.9 14.8 8.8 1.5 9.8 1.0 3.1 5.5 9.5 7.2 11.1 6.4 3.5 5.7 3.8 2.3 13.3 3.5 3.4 10.0 10.6 8.3 3.3 3.0 1.2 6.4 6.8 7.8 6.1 8.4 12.7 1.8 6.9 5.2 2.2 8.4 3.3 5.5 1.0 3.3 4.8 3.6 6.1 1.4 4.4 15.9 10.9 1.3 5.3 1.3 0.5 7.6 3.7 7.1 3.1 3.6 3.2 9.5 2.6 3.5 1.2 2.7 5.4 7.7 6.9 1.1 4.6 0.0 3.7 4.6 13.0 3.7 0.0 2.8 3.2 7.3 3.2 0.0 1.9 0.0 9.2 3.7 4.4 2.6 5.5 12.0 5.1 5.9 0.0 6.7 0.4 0.0 2.2 9.1 2.2 1.2 2.4 7.2 1.1 0.0 0.0 0.1 9.6 2.8 18.2 5.2 2.9 3.9 4.9 1.1 3.9 29.8 0.0 3.4 1.3 0.6 3.0 4.2 4.6 0.0 11.7 2.4 3.5 0.0 0.3 0.2 0.6 0.4 0.3 0.0 1.4 1.0 0.3 0.0 2.3 1.6 0.0 3.6 0.3 0.3 1.5 0.6 8.8 9.8 5.5 9.5 10.0 10.6 6.4 6.8 6.9 6.1 10.9 7.1 0.3 3.2 4.4 5.2 0.2 2.2 2.3 2.2 5.7 6.1 3.0 3.2 2.0 2.8 4.0 1.8 2.1 4.6 0.8 5.8 1.9 5.2 6.3 15.8 6.7 0.8 0.0 0.8 8.3 1.5 2.3 3.4 4.1 5.8 1.3 4.0 0.7 0.8 0.9 8.4 6.7 2.8 4.1 0.0 0.2 4.3 4.4 1.1 0.0 1.0 0.3 5.0 2.1 3.0 2.9 1.4 1.6 6.8 0.3 3.0 7.3 6.3 21.9 15.0 6.6 1.1 3.2 30.2 3.4 0.8 2.3 4.0 1.1 11.6 3.4 1.2 CDK3 ENSG00000250506 "Cyclin dependent kinase 3" Q00526 17 76000906-76005999 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Breast glandular cells: 5.3;Breast myoepithelial cells: 5.0;Glandular and luminal cells: 5.2;Granulosa cells: 6.3;Ionocytes: 10.2" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" HPA007420 Uncertain Approved Cytosol NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 18: Non-specific - Mitochondria" "Cluster 24: NB-4 - Immune response" "Cluster 7: Non-specific - Mitochondria" Cytosol "HPA007420: AB_1078490" "unprognostic (6.77e-2)" "unprognostic (1.26e-1)" "unprognostic (3.69e-2)" "unprognostic (1.87e-3)" "unprognostic (6.41e-2)" "unprognostic (1.10e-3)" "unprognostic (1.61e-2)" "unprognostic (1.56e-1)" "unprognostic (8.12e-3)" "unprognostic (1.34e-1)" "unprognostic (9.80e-5)" "unprognostic (1.19e-2)" "unprognostic (6.75e-7)" "unprognostic (4.25e-2)" "unprognostic (1.63e-2)" "unprognostic (4.68e-1)" "unprognostic (4.47e-4)" 12.7 11.0 11.4 7.7 11.8 10.6 12.2 11.5 13.8 15.7 12.0 14.9 10.4 11.5 10.7 11.1 13.7 10.3 8.4 11.3 12.2 18.4 34.8 14.2 10.5 12.0 11.7 15.9 15.1 4.8 19.7 8.9 12.2 25.7 10.1 6.9 13.6 8.4 3.6 24.7 14.7 7.6 11.5 21.9 12.2 15.6 11.8 5.8 19.5 3.3 10.5 10.8 13.3 13.6 5.5 7.5 13.5 6.5 7.3 9.0 26.1 4.6 4.6 8.0 7.4 7.0 11.0 6.5 4.5 5.7 4.6 11.6 10.2 4.1 5.6 3.3 14.1 12.7 17.8 7.3 6.7 5.9 14.9 8.7 10.8 7.3 5.1 13.0 6.9 4.1 5.6 4.5 4.3 12.1 6.3 21.8 6.3 3.8 8.4 10.4 5.2 7.2 6.9 15.8 8.4 22.0 3.8 12.0 3.2 14.2 17.4 10.9 5.5 16.4 9.6 5.4 6.7 9.9 7.2 6.2 5.4 5.5 3.9 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.5 0.1 11.4 11.8 11.5 13.8 11.3 12.2 12.0 11.7 12.2 11.5 11.8 13.6 4.3 0.0 0.0 0.0 0.5 2.7 0.0 4.0 0.0 0.0 5.3 5.0 0.3 0.0 2.2 0.0 0.0 0.0 3.1 0.0 1.9 2.0 0.0 2.9 3.9 1.4 0.0 0.0 0.0 2.3 0.0 1.3 0.0 5.2 0.0 6.3 0.0 0.0 0.0 0.0 0.0 0.0 10.2 0.0 4.4 0.0 0.0 1.4 3.6 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.5 0.0 0.0 1.2 2.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 2.7 0.0 1.0 2.8 0.0 0.0 CDK4 PSK-J3 ENSG00000135446 "Cyclin dependent kinase 4" P11802 12 57747727-57756013 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Cancer enriched" "Detected in all" 5 "glioma: 175.8" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Group enriched" "Detected in all" 10 "HBEC3-KT: 2594.8;LHCN-M2: 2819.4;RH-30: 8902.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006024, CAB013116, CAB069405" Supported Supported "Nucleoplasm,Nuclear membrane,Nucleoli,Cytosol" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 89: Fibroblasts - ECM organization" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 39: Non-specific - Basic cellular processes" Cytosol "Nucleoplasm, Nuclear membrane, Nucleoli" "CAB013116: AB_2536376, CAB069405: AB_1613464, HPA006024: AB_2667497" "unprognostic (8.88e-2)" "unprognostic (2.53e-1)" "unprognostic (5.27e-2)" "unprognostic (9.01e-2)" "unprognostic (2.21e-1)" "unprognostic (1.10e-1)" "prognostic unfavorable (2.09e-7)" "unprognostic (7.39e-2)" "unprognostic (3.23e-3)" "unprognostic (2.93e-2)" "unprognostic (3.19e-2)" "unprognostic (9.10e-2)" "prognostic unfavorable (3.15e-5)" "unprognostic (3.32e-1)" "unprognostic (1.67e-1)" "unprognostic (3.64e-1)" "unprognostic (1.57e-2)" 69.7 87.8 35.0 52.8 37.9 72.0 76.6 37.7 36.9 84.3 35.9 62.6 40.2 97.4 64.2 57.2 69.4 57.1 58.9 33.6 37.1 58.5 51.5 58.0 66.8 37.1 36.9 97.3 70.9 63.5 67.7 52.4 36.8 52.7 63.3 14.5 54.4 54.1 48.2 58.9 47.2 80.4 37.3 51.5 54.8 24.1 37.3 67.6 66.0 52.7 70.6 71.6 60.7 37.6 207.1 235.7 295.7 268.0 253.7 220.7 210.4 116.1 347.9 468.5 385.7 338.2 189.1 297.4 200.2 173.6 293.2 158.0 396.3 2594.8 354.9 150.9 209.0 275.4 149.5 237.9 297.0 309.7 182.5 221.5 180.9 294.2 326.7 326.4 304.8 280.0 301.3 242.7 2819.4 304.9 296.7 256.5 347.0 208.0 249.8 267.3 8902.5 272.1 147.2 320.6 271.2 251.7 205.3 150.2 310.0 195.1 202.8 380.7 146.1 233.6 217.0 265.8 233.1 122.2 206.1 450.8 214.1 291.3 286.9 9.5 46.5 10.3 79.6 65.6 81.8 93.5 70.0 72.5 66.7 90.0 93.0 84.4 4.4 56.6 41.9 84.9 57.0 73.6 35.0 37.9 37.7 36.9 33.6 37.1 37.1 36.9 36.8 37.3 37.3 37.6 47.1 22.4 30.8 7.8 40.0 89.7 78.6 83.4 74.0 15.9 67.2 82.2 0.7 51.5 35.3 47.8 10.4 82.9 26.1 15.9 70.5 93.1 13.5 14.9 77.7 50.8 45.6 98.0 5.2 62.5 134.5 79.4 28.5 22.6 69.1 60.2 39.7 35.8 132.9 18.5 6.7 42.2 40.7 25.1 44.1 8.0 64.0 31.2 53.4 6.5 41.9 51.4 29.9 5.5 8.0 48.3 18.9 63.2 57.8 113.9 14.0 80.9 7.4 17.9 32.9 62.1 61.9 32.1 48.3 74.5 86.1 46.8 32.3 78.8 78.7 49.4 CDK5 PSSALRE ENSG00000164885 "Cyclin dependent kinase 5" Q00535 7 151053815-151057897 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Biological rhythms, Cell cycle, Cell division, Neurogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Lissencephaly, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 65.8" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008909, HPA064535" Enhanced Supported "Nucleoplasm,Plasma membrane,Cell Junctions" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 65: Brain - Ion transport" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Plasma membrane" "Cell Junctions" "CAB008909: , HPA064535: AB_2685280" "unprognostic (1.21e-1)" "unprognostic (3.23e-2)" "unprognostic (4.22e-2)" "unprognostic (1.43e-1)" "unprognostic (1.10e-1)" "unprognostic (3.48e-1)" "unprognostic (5.67e-3)" "unprognostic (1.05e-2)" "unprognostic (1.22e-1)" "unprognostic (5.78e-3)" "unprognostic (6.25e-3)" "unprognostic (3.35e-1)" "unprognostic (4.47e-2)" "unprognostic (1.46e-2)" "unprognostic (1.77e-1)" "unprognostic (2.88e-1)" "unprognostic (1.11e-1)" 6.3 16.8 50.2 9.4 53.2 11.2 8.6 44.9 65.8 8.6 40.0 9.3 10.9 6.7 24.9 10.2 8.2 9.5 9.8 57.5 50.9 13.5 12.5 8.3 9.8 48.6 45.3 4.5 9.5 22.8 14.7 8.6 48.4 8.8 9.9 11.3 9.6 10.2 8.5 9.5 8.6 10.4 43.2 9.4 7.9 4.9 50.1 14.2 10.0 7.2 11.6 8.8 6.0 50.9 31.9 40.8 37.3 59.7 48.8 36.1 17.8 24.4 41.7 47.9 40.3 31.2 31.0 34.7 71.3 31.8 63.5 23.5 67.8 40.6 22.6 24.9 43.3 38.2 32.4 30.7 31.6 29.0 64.4 37.9 28.7 39.0 13.5 62.8 38.8 57.6 36.3 24.0 50.7 68.4 76.4 57.9 39.3 57.2 80.5 38.9 14.8 41.5 46.2 27.9 23.0 97.8 30.9 37.7 43.8 36.0 18.6 25.9 22.7 42.2 10.3 31.2 39.2 52.1 61.4 13.7 66.4 46.5 75.8 18.9 39.4 20.1 13.5 46.2 11.1 13.3 12.8 13.6 44.7 12.8 9.8 11.8 5.7 19.9 36.4 26.9 31.9 23.8 50.2 53.2 44.9 65.8 57.5 50.9 48.6 45.3 48.4 43.2 50.1 50.9 7.6 0.0 6.0 1.6 6.2 3.6 8.2 18.0 6.2 12.1 9.6 10.4 3.1 8.6 14.7 11.0 2.1 26.8 5.4 8.0 39.2 21.4 0.8 14.9 10.9 8.9 9.0 12.2 5.8 18.9 12.3 7.6 9.7 9.3 30.5 23.6 7.9 11.1 41.9 0.0 6.4 8.9 18.3 21.9 6.2 1.3 4.7 16.6 10.6 1.9 19.9 12.6 12.3 1.5 3.7 22.8 15.0 11.3 12.4 4.3 20.2 35.7 14.4 7.1 6.6 4.5 13.1 3.9 11.2 11.4 6.3 9.0 7.3 14.2 9.5 9.0 CDK6 PLSTIRE ENSG00000105810 "Cyclin dependent kinase 6" Q00534 7 92604921-92836573 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Differentiation" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets, Primary microcephaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 41.1" "Cell type enhanced" "Detected in many" "Early spermatids: 215.9;Erythroid cells: 213.5;Late spermatids: 237.0;Oligodendrocytes: 235.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "MOLT-4: 378.4;REH: 173.7" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA002637, CAB004363" Enhanced Supported Nucleoplasm,Cytosol NA NA 26000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 34: Spermatids - Unknown function" Nucleoplasm Cytosol "CAB004363: AB_627242, HPA002637: AB_1846432" "unprognostic (1.29e-1)" "unprognostic (5.98e-3)" "unprognostic (9.07e-2)" "unprognostic (2.78e-3)" "unprognostic (2.56e-2)" "unprognostic (3.24e-2)" "unprognostic (3.39e-1)" "unprognostic (2.42e-3)" "unprognostic (7.19e-2)" "unprognostic (7.78e-3)" "prognostic unfavorable (3.86e-6)" "unprognostic (4.06e-2)" "unprognostic (4.09e-3)" "unprognostic (1.09e-1)" "unprognostic (7.88e-2)" "unprognostic (1.93e-1)" "prognostic unfavorable (2.33e-5)" 3.7 7.3 6.7 4.7 7.1 18.1 4.9 5.4 5.1 4.8 2.6 5.9 6.1 3.1 2.1 4.2 2.9 3.6 4.7 4.0 5.0 4.4 5.9 4.1 6.6 6.3 6.7 2.7 6.2 9.9 1.7 17.3 6.3 3.0 7.5 0.5 5.7 4.2 1.0 6.8 7.2 3.2 5.8 4.9 9.1 3.3 9.6 41.1 2.4 2.3 6.2 3.8 4.6 8.8 27.1 11.3 34.9 23.9 10.6 11.5 5.8 27.2 18.4 14.3 13.5 34.7 20.9 21.7 14.4 19.9 8.4 15.8 20.8 42.6 34.4 43.0 10.6 50.8 23.3 34.7 6.3 33.0 2.7 11.5 23.1 17.9 90.8 13.4 5.6 75.1 49.3 55.5 26.7 5.9 378.4 3.8 9.8 37.4 9.1 173.7 112.0 36.4 20.3 0.7 18.1 113.8 3.7 9.8 17.1 26.0 0.6 54.9 19.3 44.1 63.7 18.0 54.2 27.4 0.5 27.6 6.9 112.1 60.8 0.9 0.2 0.6 0.6 0.4 0.9 0.2 0.6 0.8 0.5 0.3 0.7 0.7 0.1 0.7 0.4 0.9 0.3 0.3 6.7 7.1 5.4 5.1 4.0 5.0 6.3 6.7 6.3 5.8 9.6 8.8 38.6 25.6 3.7 2.9 17.7 60.3 23.5 55.0 62.6 0.4 20.7 21.2 18.1 22.8 32.8 22.0 0.0 53.8 30.5 12.1 9.8 37.0 215.9 3.1 29.0 30.7 16.8 213.5 114.7 23.3 5.3 28.5 42.3 6.9 25.3 39.2 11.4 27.0 16.0 0.0 60.3 63.7 28.5 23.0 48.6 237.0 5.0 27.6 19.6 108.7 22.4 0.8 39.1 119.6 235.3 94.7 22.8 3.4 85.3 47.1 20.1 8.2 11.9 0.0 6.6 100.8 32.2 2.7 33.6 36.7 50.4 17.6 42.5 62.8 92.7 27.3 CDK7 "CAK, CAK1, CDKN7, MO15, STK1" ENSG00000134058 "Cyclin dependent kinase 7" P50613 5 69234795-69277430 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, DNA damage, DNA repair, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 121.0;Extravillous trophoblasts: 343.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BEWO: 169.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004364, HPA007932, HPA008453, CAB079975" Enhanced Supported "Nucleoplasm,Nucleoli fibrillar center,Plasma membrane,Cytosol" NA NA "Cluster 24: B-cells - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 28: BEWO - Transcription regulation" "Cluster 38: Extravillous trophoblasts - Unknown function" Nucleoplasm "Nucleoli fibrillar center, Plasma membrane, Cytosol" "CAB004364: AB_627243, CAB079975: , HPA007932: AB_1078492, HPA008453: " "unprognostic (3.12e-2)" "unprognostic (1.23e-1)" "unprognostic (4.87e-2)" "unprognostic (4.53e-2)" "unprognostic (3.29e-2)" "unprognostic (4.64e-2)" "unprognostic (2.49e-3)" "unprognostic (1.64e-2)" "unprognostic (7.77e-3)" "unprognostic (1.81e-2)" "prognostic unfavorable (3.09e-4)" "unprognostic (3.40e-2)" "prognostic unfavorable (9.42e-7)" "unprognostic (2.61e-1)" "unprognostic (2.38e-1)" "unprognostic (3.86e-2)" "unprognostic (1.55e-2)" 13.4 19.8 9.4 9.5 10.2 29.1 14.8 10.9 12.9 17.5 11.5 13.7 13.3 12.1 12.9 37.3 12.5 6.4 12.4 9.5 10.5 18.4 13.6 12.7 4.8 9.7 9.7 11.7 14.1 3.2 18.2 16.2 9.8 13.7 7.4 12.8 18.9 4.8 26.8 25.3 12.2 7.7 9.8 12.6 13.5 30.6 10.0 9.3 13.2 15.0 13.3 16.1 19.9 9.4 42.8 5.9 19.4 30.6 6.4 24.4 169.5 30.9 37.5 46.2 42.9 62.2 64.5 3.7 36.4 36.8 34.2 65.3 10.8 31.3 40.6 9.0 3.1 8.6 21.4 25.9 32.8 17.9 33.8 7.1 61.3 1.8 46.0 24.5 32.5 22.3 16.3 16.1 13.3 33.3 9.4 51.7 20.7 2.8 25.4 12.3 0.7 27.1 42.6 25.4 8.6 17.5 11.6 50.4 42.4 28.1 44.9 39.3 7.4 17.1 27.4 33.1 18.2 14.4 30.4 16.5 31.4 10.2 15.5 27.9 7.9 16.2 5.3 8.9 7.9 10.6 7.8 10.6 7.3 14.5 5.9 6.4 8.2 8.6 4.7 8.9 10.5 6.1 9.4 10.2 10.9 12.9 9.5 10.5 9.7 9.7 9.8 9.8 10.0 9.4 12.2 16.0 13.2 10.7 7.8 57.7 21.4 32.9 15.4 6.4 12.3 14.7 11.3 10.0 20.2 5.5 12.5 121.0 11.7 10.2 15.6 27.8 26.8 33.1 10.7 11.6 3.0 9.9 17.6 21.6 343.6 13.0 9.7 27.2 15.8 7.4 7.1 6.7 24.0 1.7 13.7 12.3 20.3 8.5 6.0 7.9 7.5 8.5 7.2 11.2 11.6 10.4 15.5 8.0 11.9 29.3 16.2 7.2 5.8 28.2 12.3 29.3 42.4 8.7 26.3 10.0 12.5 70.1 18.6 15.9 41.9 64.6 11.4 6.8 13.2 29.8 CDK8 K35 ENSG00000132964 "Cyclin dependent kinase 8" P49336 13 26254104-26405238 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase" "Autism spectrum disorder, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 118.7;Inhibitory neurons: 175.4;Late spermatids: 100.4;Oligodendrocyte precursor cells: 149.3;Oligodendrocytes: 91.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044721 Approved Nucleoplasm NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 45: Intestine - Brush border" "Cluster 1: K-562 - Erythropoiesis" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA044721: AB_2679059" "unprognostic (3.28e-3)" "unprognostic (2.25e-3)" "unprognostic (2.08e-1)" "unprognostic (3.88e-3)" "unprognostic (2.30e-2)" "unprognostic (1.05e-2)" "unprognostic (6.42e-3)" "unprognostic (1.85e-2)" "unprognostic (5.00e-2)" "unprognostic (8.57e-2)" "unprognostic (2.52e-1)" "unprognostic (3.18e-3)" "unprognostic (2.12e-1)" "prognostic favorable (9.23e-4)" "unprognostic (1.43e-2)" "unprognostic (1.88e-1)" "unprognostic (6.37e-2)" 4.4 2.9 2.2 3.5 2.5 3.2 3.0 7.6 3.0 2.9 1.2 10.5 7.7 4.0 3.2 5.1 2.5 3.9 4.1 3.0 2.7 5.1 5.7 2.9 3.1 2.7 3.0 2.5 7.1 5.1 2.1 5.9 2.4 3.5 6.0 8.5 4.6 6.9 5.0 3.1 7.5 6.6 2.1 2.5 5.0 9.7 2.6 5.9 3.4 5.2 4.1 6.2 2.5 2.1 10.1 8.4 16.5 16.4 8.3 10.2 10.3 19.6 13.2 13.8 10.0 23.8 13.6 10.7 8.3 9.8 11.6 12.2 18.7 12.9 17.2 25.8 10.3 20.5 6.4 8.2 5.8 32.3 11.4 7.5 12.2 10.7 17.3 7.8 10.2 18.1 32.1 0.0 12.5 10.7 25.2 15.1 13.2 15.5 9.9 15.4 15.9 7.6 8.2 9.2 13.6 8.6 8.1 15.1 13.9 12.7 5.5 14.6 10.5 8.8 11.3 16.1 10.4 7.8 15.2 19.3 5.5 13.2 10.7 0.1 0.2 1.0 0.2 0.4 0.4 0.2 0.3 0.4 0.4 0.4 0.4 0.3 0.0 0.2 0.3 0.2 0.2 0.2 2.2 2.5 7.6 3.0 3.0 2.7 2.7 3.0 2.4 2.1 2.6 2.1 6.5 9.6 4.4 63.6 11.2 19.8 7.7 5.9 8.6 20.5 6.4 5.0 5.9 10.0 6.8 1.8 25.0 8.2 9.5 11.7 9.8 8.9 66.4 7.8 7.7 6.6 8.4 9.9 118.7 8.2 9.7 9.4 14.3 7.4 0.0 8.9 6.8 8.0 8.0 18.5 175.4 7.6 10.2 9.1 11.3 100.4 7.8 7.9 8.8 58.1 8.4 7.7 6.2 149.3 91.9 11.5 10.9 8.2 14.4 14.9 18.0 15.3 5.3 17.3 6.6 67.6 10.9 32.9 18.3 12.8 23.9 9.7 10.8 11.2 11.7 16.2 CDK9 "C-2k, CDC2L4, PITALRE, TAK" ENSG00000136807 "Cyclin dependent kinase 9" P50750 9 127785679-127790792 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004216, HPA006738" Supported Approved "Nucleoplasm,Cytoplasmic bodies" NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 29: U-266 - Adaptive immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Nucleoplasm "Cytoplasmic bodies" "CAB004216: AB_627245, HPA006738: AB_1078493" "unprognostic (3.60e-1)" "unprognostic (1.71e-1)" "unprognostic (5.44e-3)" "unprognostic (1.04e-3)" "unprognostic (1.93e-1)" "unprognostic (3.97e-2)" "unprognostic (2.07e-1)" "unprognostic (5.84e-2)" "unprognostic (2.66e-1)" "unprognostic (8.36e-2)" "unprognostic (1.24e-3)" "unprognostic (3.11e-2)" "prognostic unfavorable (8.92e-4)" "unprognostic (1.37e-1)" "unprognostic (1.00e-1)" "unprognostic (3.52e-2)" "unprognostic (8.78e-3)" 44.6 60.8 44.3 23.7 43.7 47.0 40.3 40.8 53.8 55.5 35.4 49.3 19.7 49.3 21.1 35.4 65.6 23.7 40.4 50.8 42.0 44.5 65.1 47.2 35.1 44.7 44.1 88.5 44.4 19.2 67.0 18.7 41.1 44.1 12.2 11.1 29.7 23.3 28.3 38.7 40.9 19.1 42.7 65.6 37.4 44.3 42.1 31.9 42.1 17.1 20.9 38.9 40.5 44.4 22.5 40.5 24.9 27.6 27.6 21.4 32.1 22.9 33.3 23.4 20.9 30.3 25.0 39.5 25.7 26.0 32.1 44.2 16.5 37.3 8.9 34.8 19.0 37.1 45.2 25.3 40.2 36.3 56.5 37.9 44.5 24.8 27.7 30.0 48.5 34.8 32.6 51.7 21.2 60.1 39.5 54.5 55.0 34.3 41.9 112.2 21.2 57.0 34.2 24.9 24.5 29.2 34.5 35.8 20.9 19.3 45.0 33.9 56.4 27.8 30.9 24.1 22.3 92.5 76.4 34.7 26.1 24.4 25.9 4.1 3.7 5.8 10.3 5.1 10.1 3.6 5.7 8.3 4.8 6.6 6.3 7.9 5.4 22.4 7.5 9.9 4.4 3.6 44.3 43.7 40.8 53.8 50.8 42.0 44.7 44.1 41.1 42.7 42.1 44.4 43.1 12.8 12.4 39.8 27.1 24.1 27.6 15.8 18.8 13.9 17.9 10.9 14.1 20.0 10.8 11.0 2.1 22.5 28.5 17.1 15.6 31.3 4.4 26.4 22.7 35.6 19.2 15.4 18.1 37.2 22.3 23.0 24.5 25.3 25.3 18.1 33.5 26.4 23.3 25.2 17.0 12.7 8.2 18.8 23.4 6.2 19.6 24.2 16.0 22.5 44.7 17.5 33.0 12.5 16.8 32.9 13.7 31.2 22.2 28.9 14.5 16.7 20.4 7.9 0.0 21.6 22.1 8.9 22.9 19.9 22.0 51.3 24.7 54.5 13.7 31.4 CDKL1 KKIALRE ENSG00000100490 "Cyclin dependent kinase like 1" Q00532 14 50326265-50416461 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 23.4;Excitatory neurons: 46.2;Oligodendrocyte precursor cells: 46.8;Oligodendrocytes: 25.4" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "SK-BR-3: 18.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA059605, HPA065919" Uncertain Enhanced Nucleoplasm,Vesicles NA NA "Cluster 46: Basophils - DNA binding" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm Vesicles "HPA059605: AB_2684080, HPA065919: AB_2685578" "unprognostic (4.12e-3)" "unprognostic (3.22e-1)" "unprognostic (4.54e-2)" "unprognostic (8.04e-2)" "unprognostic (1.64e-2)" "unprognostic (1.02e-1)" "unprognostic (3.23e-3)" "unprognostic (9.36e-3)" "unprognostic (2.63e-1)" "unprognostic (9.99e-2)" "unprognostic (1.20e-1)" "unprognostic (9.36e-2)" "unprognostic (5.53e-8)" "unprognostic (1.21e-1)" "unprognostic (7.96e-2)" "unprognostic (9.39e-3)" "unprognostic (3.31e-3)" 13.5 3.6 3.4 4.9 4.4 3.6 3.5 1.4 9.0 13.9 3.7 8.8 13.2 13.9 3.2 5.2 15.4 5.2 2.3 5.5 2.3 19.4 1.6 6.5 6.5 2.0 2.1 13.8 1.3 1.2 0.6 6.5 2.9 5.9 6.6 20.2 2.8 9.0 7.1 13.5 6.9 8.5 2.9 7.0 4.9 2.0 1.8 1.9 7.9 1.0 2.6 6.9 6.6 8.1 7.7 4.9 3.5 4.3 5.3 6.1 2.3 2.2 3.2 1.9 2.0 4.0 5.9 6.1 2.8 3.2 3.2 5.9 0.8 0.3 1.9 8.9 3.1 12.2 4.6 3.9 6.2 9.7 5.3 1.5 3.0 3.2 8.0 2.4 6.7 10.3 3.3 4.8 1.1 2.5 2.8 4.7 1.9 2.6 3.9 3.3 3.8 3.1 5.3 6.6 4.6 3.4 4.2 18.3 2.1 1.3 2.4 6.2 4.0 6.7 4.1 7.1 5.0 2.4 1.8 2.9 1.7 8.7 7.6 3.2 1.4 2.6 3.5 1.4 3.1 2.6 2.3 3.2 0.8 3.0 1.9 1.9 0.7 2.3 0.2 0.8 2.4 1.3 3.4 4.4 1.4 9.0 5.5 2.3 2.0 2.1 2.9 2.9 1.8 8.1 3.2 19.2 9.9 6.5 3.0 3.1 4.1 0.2 3.4 0.7 0.4 0.5 0.5 0.0 2.6 11.0 0.0 0.1 2.3 7.2 5.9 1.4 0.4 23.4 9.6 3.3 1.8 6.1 46.2 1.8 0.1 7.6 1.1 4.9 1.3 3.2 6.4 0.3 0.4 0.0 20.6 2.1 2.0 0.9 1.5 1.5 9.0 1.5 0.0 7.5 0.8 0.9 2.1 46.8 25.4 1.9 4.8 3.4 0.2 3.1 4.9 8.0 20.4 0.7 0.0 4.0 4.6 0.0 0.3 4.7 2.7 0.3 4.2 3.6 5.2 2.2 CDKL2 "KKIAMRE, P56" ENSG00000138769 "Cyclin dependent kinase like 2" Q92772 4 75576496-75630716 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 8.3;choroid plexus: 8.6;retina: 9.6;testis: 11.6" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 76.4;Early spermatids: 57.8;Excitatory neurons: 32.8;Inhibitory neurons: 40.9;Oligodendrocytes: 46.4;Spermatocytes: 101.7" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 2.1;HHSteC: 1.9;RPTEC TERT1: 4.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040672 Approved Nucleoplasm,Centrosome NA NA "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 66: Spermatocytes - Spermatogenesis" "Nucleoplasm, Centrosome" "HPA040672: AB_10794744" "unprognostic (2.07e-1)" "unprognostic (9.96e-2)" "unprognostic (6.91e-2)" "unprognostic (3.80e-5)" "unprognostic (3.43e-2)" "unprognostic (2.71e-2)" "unprognostic (1.59e-1)" "unprognostic (8.14e-3)" "unprognostic (1.58e-1)" "unprognostic (1.62e-1)" "unprognostic (5.85e-2)" "unprognostic (1.27e-1)" "prognostic favorable (6.88e-15)" "unprognostic (5.91e-2)" "unprognostic (1.70e-1)" "unprognostic (1.64e-1)" "unprognostic (7.52e-2)" 0.1 1.0 6.3 0.3 6.7 0.0 0.3 4.1 8.3 0.6 8.6 0.7 0.1 0.6 0.9 0.8 1.6 0.4 0.3 6.5 6.1 5.9 0.0 4.7 0.3 6.0 4.8 1.6 0.5 2.5 1.5 0.0 6.5 0.6 0.9 9.6 0.3 0.6 0.0 0.2 0.1 0.4 4.9 0.1 0.6 11.6 5.8 0.0 3.1 0.0 0.6 0.2 0.3 8.3 2.1 0.3 0.1 0.0 0.1 0.1 0.0 0.1 0.8 1.0 0.9 0.1 0.5 0.0 0.3 0.0 1.0 0.2 0.0 0.2 0.9 0.1 1.5 0.0 0.1 0.0 1.9 0.0 0.0 0.6 1.0 0.1 0.3 0.9 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 4.2 0.1 1.1 0.9 0.0 0.0 0.5 1.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.7 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 6.3 6.7 4.1 8.3 6.5 6.1 6.0 4.8 6.5 4.9 5.8 8.3 0.2 25.6 76.4 5.9 0.4 0.1 0.5 0.6 0.6 17.7 0.7 3.0 0.9 1.5 4.7 9.2 4.2 0.1 0.3 3.0 7.9 1.9 57.8 11.6 1.4 0.2 1.8 0.0 32.8 0.2 0.6 1.2 1.1 2.5 1.3 1.0 0.4 0.0 0.1 10.1 40.9 2.3 0.0 0.0 0.4 20.7 1.8 0.5 1.8 3.7 0.0 11.6 0.0 5.5 46.4 0.1 1.0 1.2 0.3 0.2 0.0 29.5 18.6 20.2 0.0 0.4 1.1 101.7 4.1 0.8 0.3 0.3 2.7 0.2 2.7 0.2 CDKL3 NKIAMRE ENSG00000006837 "Cyclin dependent kinase like 3" Q8IVW4 5 134286350-134371047 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 16.2" "Group enriched" "Detected in many" 6 "Early spermatids: 342.0;Late spermatids: 295.3" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027751 Uncertain Nucleoplasm,Vesicles NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 78: Testis - Spermatogenesis" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 23: Spermatids - Flagellum & Golgi organization" "Nucleoplasm, Vesicles" "HPA027751: AB_10601256" "unprognostic (4.70e-2)" "unprognostic (2.15e-2)" "unprognostic (2.35e-1)" "unprognostic (1.48e-1)" "unprognostic (1.43e-1)" "unprognostic (3.98e-2)" "unprognostic (3.43e-3)" "unprognostic (5.93e-2)" "unprognostic (2.12e-3)" "unprognostic (1.49e-1)" "unprognostic (8.47e-4)" "unprognostic (2.82e-1)" "unprognostic (9.85e-4)" "unprognostic (8.33e-2)" "unprognostic (4.88e-2)" "unprognostic (7.10e-3)" "unprognostic (3.43e-3)" 0.7 0.8 2.5 0.5 2.8 0.2 0.6 2.5 4.4 0.8 1.3 0.8 0.5 1.1 0.6 0.6 1.2 0.6 2.7 2.4 2.7 1.5 0.8 0.5 0.7 2.9 2.6 0.7 0.5 1.0 0.6 0.4 3.0 0.7 0.6 4.2 0.4 0.8 3.4 0.6 0.6 1.5 3.1 0.7 0.5 16.2 2.8 0.9 1.2 3.3 0.9 0.6 0.5 5.0 0.5 1.3 1.7 1.2 2.7 2.4 0.7 1.7 1.4 0.7 1.7 1.2 0.8 1.3 1.0 1.1 3.3 0.5 1.5 1.0 1.2 1.6 1.0 0.8 1.7 1.9 1.7 0.3 0.5 1.1 2.5 2.2 0.6 1.2 0.7 3.4 1.1 0.7 1.9 0.6 1.2 4.6 1.2 0.3 0.5 1.9 0.6 0.4 0.9 0.5 2.5 0.8 1.8 0.1 2.1 1.8 1.0 0.9 0.5 1.4 0.3 1.9 0.5 1.8 2.5 2.9 2.1 1.4 1.1 0.0 0.3 0.3 0.3 0.4 1.4 0.5 0.4 0.9 1.0 0.3 1.3 1.3 0.0 0.6 0.1 0.5 0.9 0.4 2.5 2.8 2.5 4.4 2.4 2.7 2.9 2.6 3.0 3.1 2.8 5.0 4.1 0.0 3.7 50.6 2.0 10.8 6.4 18.8 4.0 13.3 4.5 5.8 2.2 2.8 9.9 5.5 4.2 3.1 3.2 0.5 9.8 3.5 342.0 7.5 6.4 4.6 3.0 4.8 41.6 5.1 1.8 6.2 1.5 3.7 3.8 7.0 3.6 2.3 3.6 6.7 52.0 1.5 18.3 2.1 19.4 295.3 5.0 2.8 10.6 16.9 2.4 10.8 3.1 32.6 50.7 1.5 1.6 9.1 1.4 4.3 1.3 9.5 12.9 9.7 0.0 6.3 7.9 35.3 17.2 1.7 11.1 4.5 3.4 6.2 0.9 3.8 CDKL4 ENSG00000205111 "Cyclin dependent kinase like 4" Q5MAI5 2 39175646-39229588 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "choroid plexus: 2.0;testis: 2.9" "Cell type enhanced" "Detected in some" "Early spermatids: 11.8;Excitatory neurons: 5.4;Late spermatids: 6.8;Respiratory ciliated cells: 5.9;Spermatocytes: 8.7;Spermatogonia: 4.3" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HL-60: 2.1;RT4: 1.3;SH-SY5Y: 2.6" "Low region specificity" "Detected in all" HPA067895 Uncertain NA NA "Cluster 35: T-regs - Unknown function" "Cluster 49: Ciliated cells - Cilium organization" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA067895: AB_2685920" "unprognostic (3.57e-2)" "unprognostic (3.92e-2)" "unprognostic (1.14e-1)" "unprognostic (1.98e-2)" "unprognostic (3.29e-1)" "unprognostic (7.46e-3)" "unprognostic (3.26e-2)" "unprognostic (4.26e-1)" "unprognostic (3.82e-2)" "unprognostic (6.13e-3)" "unprognostic (1.77e-2)" "unprognostic (8.43e-2)" "unprognostic (8.45e-4)" "unprognostic (8.59e-2)" "unprognostic (4.95e-1)" "unprognostic (3.08e-1)" "unprognostic (3.26e-2)" 0.1 0.4 0.6 0.0 0.6 0.0 0.1 0.7 0.7 0.1 2.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.1 0.7 1.1 0.1 0.0 0.2 0.1 0.5 0.6 0.1 0.1 0.2 0.5 0.4 0.5 0.1 0.0 0.3 0.0 0.0 0.1 0.1 0.1 0.0 0.2 0.1 0.1 2.9 1.0 0.0 0.1 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.1 2.1 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.1 1.3 0.2 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.6 0.6 0.7 0.7 0.7 1.1 0.5 0.6 0.5 0.2 1.0 0.4 0.5 3.2 0.0 0.7 0.0 0.1 0.2 0.3 0.0 0.1 0.6 0.5 0.2 0.0 2.0 0.0 0.0 0.2 0.2 0.2 0.0 0.2 11.8 1.2 0.3 0.3 0.0 0.0 5.4 0.2 0.4 0.2 1.1 1.8 0.0 0.2 0.0 0.1 0.2 0.0 3.4 0.0 2.0 0.0 0.0 6.8 0.3 0.2 0.0 1.9 0.0 0.2 0.0 1.5 0.4 0.4 0.1 0.4 0.1 0.4 0.0 0.3 5.9 0.8 0.0 0.5 0.1 8.7 4.3 0.0 0.0 0.0 0.3 0.2 0.0 0.1 CDKL5 "CFAP247, EIEE2, STK9" ENSG00000008086 "Cyclin dependent kinase like 5" O76039 X 18425583-18653629 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 216.6;Horizontal cells: 80.8;Inhibitory neurons: 116.1;Oligodendrocytes: 79.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "basophil: 5.7" "Lineage enriched" "Detected in single" 11 "granulocytes: 5.7" "Cell line enhanced" "Detected in many" "A549: 10.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002847, CAB011577" Approved Supported Nucleoplasm NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 58: Brain - Synaptic function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "CAB011577: AB_727019, HPA002847: AB_1080107" "unprognostic (7.01e-2)" "unprognostic (4.86e-2)" "unprognostic (1.41e-1)" "unprognostic (1.25e-4)" "unprognostic (1.17e-1)" "unprognostic (1.61e-2)" "unprognostic (1.72e-2)" "unprognostic (1.67e-1)" "unprognostic (2.07e-1)" "unprognostic (9.63e-3)" "unprognostic (2.05e-3)" "unprognostic (1.66e-1)" "prognostic favorable (5.54e-4)" "unprognostic (7.67e-3)" "unprognostic (1.29e-1)" "unprognostic (2.67e-3)" "unprognostic (1.99e-1)" 2.0 1.6 4.9 1.1 6.7 2.5 2.5 0.0 11.7 3.9 0.0 1.9 0.9 2.6 1.9 3.5 1.7 1.8 3.8 6.8 0.0 3.5 1.2 4.6 0.8 0.0 2.5 3.8 2.4 2.4 1.7 3.2 0.0 3.6 1.2 12.2 2.2 2.3 1.7 2.2 0.9 2.5 0.0 1.2 2.4 7.1 5.7 1.7 3.0 2.0 1.1 2.7 3.4 5.4 1.1 10.0 2.6 2.2 2.4 3.6 1.7 1.7 3.0 2.0 2.5 3.3 1.5 1.5 0.3 1.0 4.5 0.5 3.2 1.8 4.3 0.4 1.7 0.1 5.5 2.1 1.1 0.2 0.7 1.7 1.9 5.4 4.9 1.3 1.0 1.6 0.2 1.5 2.7 1.0 0.6 0.8 5.2 0.9 2.3 0.6 3.0 0.1 1.8 7.1 0.5 3.2 2.7 0.9 1.5 4.4 1.3 0.4 6.2 2.5 1.7 5.5 1.3 0.3 0.1 0.3 1.4 0.4 3.0 5.7 0.5 1.1 0.3 0.3 0.1 0.1 0.2 0.1 0.1 0.3 0.3 0.2 2.0 0.2 0.3 0.5 0.1 0.1 4.9 6.7 0.0 11.7 6.8 0.0 0.0 2.5 0.0 0.0 5.7 5.4 9.4 25.6 24.8 37.5 2.8 0.9 10.7 0.7 4.6 19.0 7.9 6.3 12.9 5.7 5.3 7.3 33.3 27.4 3.8 1.3 7.9 7.7 34.3 6.5 8.4 6.3 2.4 2.7 216.6 9.6 3.1 7.4 7.7 7.9 1.3 3.9 6.1 3.4 4.2 80.8 116.1 1.6 2.0 4.4 0.5 55.3 5.9 4.9 0.0 34.7 4.6 23.5 0.0 41.7 79.7 8.2 0.8 5.3 4.3 16.2 0.6 8.9 4.0 20.4 32.9 7.2 8.4 5.8 10.1 4.2 1.3 47.3 2.3 5.7 1.8 22.9 CDKN3 "CDI1, KAP" ENSG00000100526 "Cyclin dependent kinase inhibitor 3" Q16667 14 54396849-54420218 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle" "Hydrolase, Protein phosphatase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "testis: 207.0" "Cell type enhanced" "Detected in many" "Early spermatids: 2630.9;Late spermatids: 659.4;Spermatocytes: 606.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "T-reg: 18.8" "Group enriched" "Detected in all" 6 "NK-cells: 6.4;T-cells: 18.8" "Low cell line specificity" "Detected in all" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB005285, HPA039311, HPA058874" Enhanced Cytosol NA Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 29: Early spermatids - Spermatogenesis" Cytosol "CAB005285: AB_2078884, HPA039311: , HPA058874: AB_2683842" "unprognostic (3.46e-2)" "unprognostic (9.95e-2)" "unprognostic (5.79e-2)" "unprognostic (6.78e-3)" "unprognostic (2.73e-1)" "unprognostic (6.08e-2)" "unprognostic (1.51e-3)" "prognostic unfavorable (4.52e-4)" "unprognostic (2.50e-3)" "unprognostic (2.85e-3)" "prognostic unfavorable (7.46e-4)" "unprognostic (5.89e-2)" "prognostic unfavorable (0.00e+0)" "unprognostic (1.71e-1)" "unprognostic (7.30e-2)" "unprognostic (7.92e-2)" "unprognostic (4.31e-2)" 3.4 1.6 2.8 12.2 2.7 43.4 3.4 5.0 4.2 2.2 3.4 13.9 12.4 2.8 0.4 10.2 1.3 2.9 5.3 2.9 3.1 2.0 2.4 2.1 28.4 2.5 2.7 1.3 1.1 0.5 1.6 6.7 3.3 1.6 16.9 2.6 3.3 0.7 3.0 5.9 12.6 7.4 2.1 4.9 5.0 207.0 3.5 30.9 1.7 4.1 30.0 5.8 4.1 2.6 276.7 102.5 74.0 78.2 12.5 15.3 46.5 63.1 97.0 135.8 146.9 81.8 136.5 139.9 44.4 96.7 135.9 195.9 114.6 78.3 245.6 169.5 59.3 65.8 69.0 126.8 10.1 86.2 47.6 5.4 4.9 84.3 138.3 44.4 88.4 129.8 36.1 162.2 159.8 186.9 118.1 67.9 27.9 254.7 216.4 72.7 66.6 29.7 70.5 56.9 30.6 42.0 118.7 67.4 52.5 54.6 142.9 69.4 33.0 59.2 195.8 91.7 155.0 38.6 47.4 91.4 98.6 120.4 110.9 0.0 1.3 1.3 1.6 1.7 0.7 2.1 5.5 4.8 1.8 0.9 2.9 2.3 1.0 6.4 1.2 1.5 18.8 3.1 2.8 2.7 5.0 4.2 2.9 3.1 2.5 2.7 3.3 2.1 3.5 2.6 1.4 0.0 0.0 0.7 10.5 9.3 4.3 9.7 4.6 3.2 6.4 11.6 9.7 0.0 2.4 1.8 2.1 42.6 2.7 7.3 0.0 3.5 2630.9 2.7 3.5 6.8 7.8 125.5 2.5 2.4 35.0 10.2 9.2 3.5 7.0 31.3 6.1 3.1 37.7 5.0 3.9 17.9 4.1 9.8 8.8 659.4 21.5 8.9 1.8 1.0 2.9 1.7 0.0 0.0 0.2 1.9 7.2 10.5 41.0 4.0 3.4 2.8 0.2 2.9 0.0 3.0 20.5 606.9 39.8 22.5 6.5 4.1 8.3 3.9 31.2 5.3 CDY1 CDY1A ENSG00000172288 "Chromodomain Y-linked 1" Q9Y6F8 Y 25622162-25624902 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA066682 Supported NA NA "HPA066682: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CDY1B ENSG00000172352 "Chromodomain Y-linked 1B" Q9Y6F8 Y 24045229-24048019 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 23 "testis: 2.2" "Cell type enhanced" "Detected in single" "Early spermatids: 1.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA066682 Supported NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 23: Spermatids - Flagellum & Golgi organization" "HPA066682: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CDY2A CDY2 ENSG00000182415 "Chromodomain Y-linked 2A" Q9Y6F7 Y 18025787-18027746 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 16 "epididymis: 1.1;testis: 2.0" "Cell type enriched" "Detected in single" 18 "Collecting duct cells: 1.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA066682 Supported NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA066682: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CDY2B CDY ENSG00000129873 "Chromodomain Y-linked 2B" Q9Y6F7 Y 17878260-17880220 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA066682 Supported NA NA "HPA066682: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CERT1 "CERT, COL4A3BP, GPBP, STARD11" ENSG00000113163 "Ceramide transporter 1" Q9Y5P4 5 75356345-75512138 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Lipid transport, Transport" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Adipocytes: 23.3;Cardiomyocytes: 37.1;Cytotrophoblasts: 17.7;dendritic cells: 20.2;Extravillous trophoblasts: 16.8;Hofbauer cells: 36.8;Plasma cells: 12.4;Syncytiotrophoblasts: 27.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "ASC diff: 132.3;WM-115: 118.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035645, HPA042608" Enhanced Enhanced "Nucleoplasm,Golgi apparatus" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 8: Non-specific - Mitochondria" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 24: Non-specific - Transcription regulation" "Golgi apparatus" Nucleoplasm "HPA035645: AB_10600700, HPA042608: AB_2678075" "unprognostic (2.45e-1)" "unprognostic (7.16e-2)" "unprognostic (6.56e-3)" "unprognostic (1.53e-2)" "unprognostic (2.44e-1)" "unprognostic (9.29e-2)" "unprognostic (4.06e-2)" "unprognostic (3.22e-1)" "unprognostic (2.51e-1)" "unprognostic (1.24e-1)" "unprognostic (1.46e-1)" "unprognostic (4.29e-2)" "prognostic favorable (1.24e-5)" "unprognostic (9.12e-2)" "unprognostic (2.29e-1)" "unprognostic (2.83e-1)" "unprognostic (2.91e-1)" 38.1 26.1 12.4 16.5 16.1 27.2 17.6 18.0 15.4 33.9 14.0 20.8 18.7 20.6 15.1 24.9 22.4 23.3 20.8 14.0 15.1 27.9 31.2 24.3 20.3 14.7 17.5 23.1 16.4 26.1 8.0 22.9 16.7 24.3 19.6 18.2 14.0 19.9 28.9 18.7 21.1 18.3 14.7 25.3 23.5 28.8 15.5 21.2 49.9 28.3 22.7 23.7 16.0 17.6 44.9 22.7 21.6 19.0 132.3 36.6 29.0 24.8 30.8 18.8 24.8 34.4 25.3 21.5 52.3 26.9 25.8 26.7 33.4 34.4 28.6 27.1 15.2 18.2 24.4 18.4 33.6 18.2 20.1 27.9 23.8 22.3 24.9 30.5 22.1 28.3 33.0 32.0 25.0 23.0 21.6 13.2 27.9 10.2 16.8 18.0 28.5 20.2 30.5 54.0 16.4 16.5 31.6 21.6 31.8 45.4 21.3 30.5 30.1 12.6 15.1 22.8 20.3 29.1 41.6 24.8 21.4 30.7 118.2 9.6 19.8 16.0 8.2 22.4 7.8 9.1 8.3 7.7 14.5 9.1 7.7 7.8 29.6 7.8 25.4 8.3 13.0 9.0 12.4 16.1 18.0 15.4 14.0 15.1 14.7 17.5 16.7 14.7 15.5 17.6 23.3 0.0 0.0 0.0 5.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 37.1 0.0 0.0 0.0 0.0 17.7 20.2 0.0 0.0 0.0 0.0 0.0 0.0 5.6 0.0 0.0 0.0 0.0 16.8 10.5 0.0 0.0 0.0 0.0 0.0 0.0 36.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.2 0.0 0.0 0.0 0.0 27.8 3.8 0.0 0.0 0.0 CES1 "CEH, CES1A1, CES1A2, CES2, HMSE, HMSE1, SES1" ENSG00000198848 "Carboxylesterase 1" P23141 16 55802851-55833337 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Serine esterase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 9 "liver: 2517.1" "Group enriched" "Detected in many" 7 "Cholangiocytes: 613.4;Hepatocytes: 2420.8" "Cancer enriched" "Detected in all" 6 "liver cancer: 711.4" "Low region specificity" "Detected in many" "Group enriched" "Detected in many" 16 "classical monocyte: 109.6;myeloid DC: 114.5" "Group enriched" "Detected in many" 22 "dendritic cells: 114.5;monocytes: 109.6" "Group enriched" "Detected in some" 5 "Hep G2: 700.9;THP-1: 688.0" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA012023, HPA046717" Enhanced Supported "Endoplasmic reticulum" "Intracellular and membrane" No NA 40000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" "Endoplasmic reticulum" "HPA012023: AB_1846554, HPA046717: AB_2679770" "unprognostic (1.04e-2)" "unprognostic (9.85e-2)" "unprognostic (2.94e-1)" "unprognostic (1.28e-1)" "unprognostic (1.55e-3)" "unprognostic (7.46e-3)" "unprognostic (1.51e-1)" "unprognostic (1.42e-1)" "unprognostic (3.51e-1)" "unprognostic (5.74e-2)" "unprognostic (4.62e-2)" "unprognostic (3.29e-2)" "unprognostic (1.91e-2)" "unprognostic (5.32e-2)" "unprognostic (1.92e-1)" "unprognostic (2.87e-1)" "prognostic unfavorable (9.92e-4)" 94.9 14.1 0.9 3.2 1.2 27.0 43.6 0.8 1.8 26.6 3.7 82.3 24.0 60.4 7.5 41.1 54.6 272.9 66.1 1.0 1.4 6.7 2517.1 167.8 1.8 2.3 1.2 20.3 8.8 0.7 3.7 8.5 1.5 39.2 12.3 2.9 41.4 36.4 5.2 14.0 27.4 40.4 1.0 41.0 56.1 7.8 1.1 2.5 9.9 9.4 1.0 57.7 17.7 1.1 0.7 4.4 0.0 0.0 90.8 0.6 3.1 0.3 0.0 0.0 0.0 43.5 0.0 0.0 19.4 0.0 1.4 0.0 0.0 0.0 0.0 0.2 0.0 0.4 0.9 700.9 0.0 1.3 0.1 0.2 0.3 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 40.8 0.1 0.6 0.0 0.0 1.5 6.7 0.0 0.5 0.0 0.1 3.2 0.1 1.1 0.9 0.0 688.0 0.1 0.0 0.4 0.2 0.5 2.2 0.1 1.0 0.0 151.7 0.0 0.0 109.6 0.5 4.5 6.1 1.5 1.1 0.7 5.0 114.5 1.2 0.7 1.1 0.6 0.3 1.6 6.8 0.4 58.0 0.9 1.2 0.8 1.8 1.0 1.4 2.3 1.2 1.5 1.0 1.1 1.1 2.0 16.0 67.6 0.0 11.3 16.7 5.3 6.8 1.2 0.0 1.2 8.1 0.8 613.4 31.5 16.5 0.0 0.5 12.2 0.1 0.0 15.4 79.6 1.0 10.6 8.9 37.5 177.7 0.0 18.7 2.2 57.4 1.1 0.2 6.3 0.0 66.0 2420.8 18.1 0.0 0.0 12.2 4.1 107.3 26.7 197.8 18.6 58.7 39.2 1.0 39.6 10.4 7.2 0.0 0.0 0.9 1.3 98.9 1.8 1.5 0.6 0.9 169.0 0.9 0.0 9.8 9.8 1.0 2.3 20.6 11.6 0.8 16.9 0.9 0.7 2.6 CES2 "CE-2, CES2A1, iCE" ENSG00000172831 "Carboxylesterase 2" O00748 16 66934444-66945096 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Serine esterase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 703.3;liver: 345.7" "Cell type enhanced" "Detected in all" "Distal enterocytes: 794.4;Hepatocytes: 518.5;Paneth cells: 519.2;Proximal enterocytes: 2529.8;Undifferentiated cells: 499.5" "Cancer enhanced" "Detected in all" "liver cancer: 104.4" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Not detected" "Not detected" "HPA018897, HPA074629" Enhanced Approved "Endoplasmic reticulum,Golgi apparatus,Cytosol" "Intracellular and membrane" NA NA 6400000 "Cluster 44: Non-specific - Transcription" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 30: Epithelial cell lines - Translation" "Cluster 45: Enterocytes - Digestion" "Golgi apparatus" "Endoplasmic reticulum, Cytosol" "HPA018897: AB_1846558, HPA074629: " "unprognostic (8.15e-3)" "unprognostic (1.82e-2)" "unprognostic (1.32e-1)" "unprognostic (2.67e-3)" "unprognostic (2.74e-2)" "unprognostic (1.38e-1)" "unprognostic (5.80e-2)" "unprognostic (1.31e-1)" "unprognostic (6.93e-2)" "unprognostic (7.99e-2)" "unprognostic (1.73e-3)" "unprognostic (2.66e-2)" "prognostic favorable (1.50e-5)" "unprognostic (8.01e-2)" "unprognostic (1.53e-1)" "unprognostic (4.14e-2)" "unprognostic (1.38e-1)" 18.8 38.1 21.2 18.1 20.6 6.3 13.5 24.1 23.0 22.0 25.6 191.2 703.3 14.6 14.4 132.7 17.9 19.5 51.4 22.1 20.6 96.5 345.7 15.6 11.9 20.8 20.8 17.0 14.4 38.0 15.7 10.1 20.6 16.7 178.8 16.2 32.9 15.0 33.8 32.7 576.5 19.7 20.0 12.4 41.6 9.3 20.9 13.1 27.9 14.3 20.8 13.7 33.5 20.5 11.6 16.6 18.4 25.9 19.5 17.9 14.5 15.9 25.8 17.6 22.1 17.3 23.5 15.7 14.3 20.9 13.3 35.4 14.2 39.8 15.3 10.7 18.9 14.4 9.6 44.2 26.3 21.6 26.3 25.4 82.5 26.0 46.7 24.6 14.1 11.3 22.2 10.9 35.7 9.1 17.7 21.4 10.8 16.3 18.8 20.9 19.1 19.8 60.7 18.6 11.6 16.0 50.9 12.6 14.5 8.1 21.0 26.5 17.5 22.4 12.6 15.3 11.1 23.3 24.0 18.4 36.7 17.3 17.4 4.1 5.4 1.6 5.1 3.8 4.5 3.0 4.1 5.8 4.5 3.1 4.8 4.5 1.6 4.3 4.1 4.3 3.2 3.1 21.2 20.6 24.1 23.0 22.1 20.6 20.8 20.8 20.6 20.0 20.9 20.5 13.2 32.1 24.6 8.8 18.8 19.5 13.5 32.8 39.3 31.2 12.4 18.3 33.6 115.8 19.8 53.3 20.9 16.1 12.9 794.4 37.2 24.6 2.1 26.9 15.0 14.1 24.1 7.8 7.0 33.8 5.7 15.3 60.6 33.7 27.3 80.7 28.5 518.5 19.6 28.6 9.7 196.0 18.3 37.0 9.6 2.3 18.6 15.3 10.6 10.3 19.5 19.0 21.6 8.0 5.9 51.8 519.2 18.0 8.5 19.1 2529.8 176.0 85.4 24.2 32.9 19.5 15.2 47.2 19.7 116.1 20.5 13.5 13.0 22.1 499.5 16.7 CES3 "ES31, FLJ21736" ENSG00000172828 "Carboxylesterase 3" Q6UWW8 16 66961245-66975149 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Serine esterase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 38.2;liver: 52.5;skeletal muscle: 24.7" "Cell type enhanced" "Detected in many" "Distal enterocytes: 120.1;Granulosa cells: 58.5;Hepatocytes: 53.4;Intestinal goblet cells: 32.0;Paneth cells: 67.0;Proximal enterocytes: 66.0;Undifferentiated cells: 44.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AN3-CA: 7.4;Daudi: 8.5;JURKAT: 13.5;U-937: 7.2" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA041008, HPA041307" Approved Approved "Nuclear membrane,Endoplasmic reticulum" "Intracellular and membrane" NA NA 1200000 "Cluster 52: Eosinophils - Transcription" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 32: U-937 - Innate immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nuclear membrane, Endoplasmic reticulum" "HPA041008: AB_2677247, HPA041307: AB_2677400" "unprognostic (3.91e-3)" "unprognostic (1.22e-1)" "unprognostic (1.94e-2)" "unprognostic (8.99e-3)" "unprognostic (9.32e-2)" "unprognostic (7.84e-4)" "prognostic favorable (7.26e-5)" "unprognostic (5.67e-3)" "unprognostic (1.52e-1)" "unprognostic (2.17e-1)" "unprognostic (6.43e-2)" "unprognostic (1.84e-2)" "unprognostic (1.19e-2)" "unprognostic (2.18e-2)" "unprognostic (2.75e-1)" "unprognostic (3.31e-2)" "unprognostic (7.41e-2)" 0.8 0.5 3.1 3.2 2.7 0.9 2.3 2.5 2.9 1.3 1.3 38.2 30.0 0.7 0.2 4.2 2.9 0.9 0.7 3.8 2.0 12.2 52.5 0.7 0.3 3.3 2.7 0.6 4.1 1.0 1.9 0.6 3.5 0.5 31.3 0.6 12.0 0.3 24.7 1.2 23.7 1.2 1.4 0.4 7.7 1.1 2.2 0.2 0.4 1.5 0.2 0.1 0.8 2.2 0.4 3.1 0.3 7.4 0.2 0.2 1.2 0.2 0.2 0.3 0.5 0.5 3.8 8.5 2.4 0.0 0.2 0.6 1.1 0.5 0.1 1.5 5.5 4.3 1.3 2.6 0.0 0.9 0.7 0.3 0.9 0.8 0.1 0.2 0.0 13.5 2.8 1.7 0.3 1.1 1.4 1.4 1.5 2.6 0.4 1.3 0.7 1.3 0.1 0.4 0.4 0.8 0.2 5.8 0.2 0.6 5.0 6.5 0.3 0.4 2.4 0.7 0.2 0.9 3.6 1.3 0.3 7.2 0.2 0.2 0.1 0.7 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.1 0.1 0.4 0.0 0.0 0.0 0.1 0.0 3.1 2.7 2.5 2.9 3.8 2.0 3.3 2.7 3.5 1.4 2.2 2.2 0.1 3.2 6.7 0.7 0.4 0.5 0.0 1.3 1.2 0.2 9.1 5.7 1.4 2.8 0.9 0.0 0.0 0.0 0.0 120.1 0.0 0.2 0.5 3.2 0.3 0.2 19.7 0.0 1.8 0.9 0.0 0.2 11.7 4.4 1.3 58.5 0.4 53.4 0.3 0.0 2.9 32.0 0.0 3.2 0.9 5.4 0.0 0.9 0.0 0.0 0.0 0.4 0.0 1.5 0.1 1.0 67.0 1.2 0.1 0.1 66.0 9.9 4.8 0.2 0.0 0.6 0.2 2.3 2.9 1.1 0.3 0.0 0.4 0.1 44.3 0.2 CES5A "CAUXIN, CES4C1, CES5, CES7, FLJ31547" ENSG00000159398 "Carboxylesterase 5A" Q6NT32 16 55846154-55956031 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Serine esterase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 17 "epididymis: 67.5" "Cell type enhanced" "Detected in some" "Cholangiocytes: 1.5;Collecting duct cells: 5.5;Excitatory neurons: 1.4;Hepatocytes: 6.9;Oligodendrocyte precursor cells: 2.0;Oligodendrocytes: 4.0" "Cancer enriched" "Detected in single" 5 "liver cancer: 0.6" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 46 "U-266/70: 7.9" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "Secreted in male reproductive system" NA NA "Cluster 30: Epididymis - Antimicrobial activity" "Cluster 29: U-266 - Adaptive immune response" "Cluster 2: Hepatocytes - Metabolism" "unprognostic (2.07e-1)" "unprognostic (2.55e-1)" "unprognostic (6.34e-2)" "unprognostic (4.82e-2)" "unprognostic (3.78e-1)" "unprognostic (2.33e-1)" "unprognostic (3.12e-2)" "unprognostic (1.72e-7)" "unprognostic (1.55e-2)" "unprognostic (2.27e-1)" 0.0 0.0 0.2 0.0 0.5 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 67.5 0.0 0.0 0.6 0.1 0.1 0.2 0.0 3.9 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.7 0.4 0.0 0.6 0.0 0.0 0.2 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.5 0.2 0.2 0.1 0.2 0.3 0.3 0.2 0.2 0.2 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 1.5 0.0 5.5 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.9 0.0 0.0 1.3 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 4.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CHD9 "BC022889, FLJ12178, KIAA0308" ENSG00000177200 "Chromodomain helicase DNA binding protein 9" Q3L8U1 16 53055033-53329150 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Chromatin regulator, DNA-binding, Helicase, Hydrolase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 502.5;Rod photoreceptor cells: 766.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042053, HPA049420, HPA066155" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 6: Non-specific - Transcription" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 14: REH - Unknown function" "Cluster 46: Photoreceptor cells - Phototransduction" Nucleoplasm Cytosol "HPA042053: AB_2677823, HPA049420: AB_2680758, HPA066155: " "unprognostic (3.57e-2)" "unprognostic (3.73e-2)" "unprognostic (3.44e-3)" "unprognostic (2.42e-1)" "unprognostic (4.34e-2)" "unprognostic (4.35e-2)" "unprognostic (1.24e-1)" "unprognostic (1.68e-1)" "unprognostic (7.75e-3)" "unprognostic (2.87e-2)" "unprognostic (3.39e-1)" "unprognostic (2.35e-2)" "prognostic favorable (1.84e-4)" "unprognostic (4.96e-2)" "unprognostic (1.74e-1)" "unprognostic (5.09e-2)" "unprognostic (2.87e-1)" 7.4 6.6 13.6 6.0 19.3 21.7 11.5 31.1 9.4 10.1 2.1 8.1 5.4 9.7 6.2 7.7 9.0 8.1 7.1 6.4 17.1 11.1 6.9 7.0 6.9 13.3 17.1 12.7 6.4 10.2 5.0 8.7 16.9 8.4 7.8 28.9 8.5 8.7 7.2 6.3 5.7 7.9 10.1 7.7 9.6 4.9 14.2 9.9 12.2 12.8 6.7 7.1 6.2 17.6 10.4 12.0 25.0 20.8 20.0 28.6 4.4 18.0 13.8 9.9 4.3 6.8 9.1 14.0 11.3 16.8 6.9 12.5 14.0 10.4 14.0 5.0 10.2 18.4 12.0 4.6 13.5 25.3 15.8 19.9 9.5 15.2 18.3 12.9 14.7 8.3 22.2 4.5 13.0 4.2 13.1 5.9 9.6 3.1 8.7 46.2 28.8 5.8 6.4 9.7 10.4 11.7 16.6 5.4 12.3 9.7 6.0 12.0 28.3 18.1 8.9 6.6 12.0 13.1 9.7 21.9 13.2 11.3 17.9 102.0 25.5 27.5 15.7 21.9 24.5 38.9 10.7 17.6 16.2 46.6 8.5 12.0 8.6 38.3 39.4 126.7 6.1 5.4 13.6 19.3 31.1 9.4 6.4 17.1 13.3 17.1 16.9 10.1 14.2 17.6 146.3 70.5 74.7 426.4 111.5 57.2 123.4 107.7 96.8 318.9 81.3 89.9 39.0 55.8 81.5 90.1 502.5 17.4 112.1 80.8 46.9 60.4 16.4 71.8 109.3 97.5 87.6 67.7 272.9 36.7 31.2 117.2 109.1 69.9 96.7 121.8 107.4 66.4 69.0 220.4 297.3 89.7 69.2 67.8 50.7 19.1 108.4 88.6 67.6 319.5 89.3 153.3 98.9 462.4 312.0 39.0 100.5 123.4 70.3 98.2 76.1 60.8 72.3 766.6 59.2 157.2 106.1 105.7 50.9 75.4 75.0 24.9 60.5 89.3 72.1 83.4 CHEK1 CHK1 ENSG00000149554 "Checkpoint kinase 1" O14757 11 125625665-125676255 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, DNA damage, DNA repair" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 25.7;lymphoid tissue: 20.7;seminal vesicle: 29.8" "Cell type enhanced" "Detected in many" "Cholangiocytes: 32.9;Erythroid cells: 34.5;Extravillous trophoblasts: 35.6;Spermatocytes: 48.9;Spermatogonia: 49.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in some" "Immune cell enhanced" "Detected in some" "T-reg: 6.2" "Group enriched" "Detected in many" 5 "granulocytes: 1.7;T-cells: 6.2" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in single" "Low region specificity" "Detected in many" HPA044364 Supported Nucleoplasm,Vesicles NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm Vesicles "HPA044364: AB_2678913" "unprognostic (6.74e-2)" "unprognostic (3.63e-1)" "prognostic favorable (3.62e-4)" "unprognostic (5.54e-2)" "unprognostic (2.17e-1)" "unprognostic (1.03e-1)" "prognostic unfavorable (3.70e-6)" "unprognostic (3.95e-3)" "unprognostic (1.26e-3)" "unprognostic (2.54e-2)" "prognostic unfavorable (3.10e-6)" "unprognostic (1.75e-1)" "prognostic unfavorable (1.04e-8)" "unprognostic (2.89e-2)" "unprognostic (2.64e-1)" "unprognostic (8.16e-2)" "unprognostic (1.33e-1)" 1.6 1.3 0.7 8.2 1.0 25.7 2.6 0.6 1.3 1.7 0.5 7.9 6.8 1.7 6.7 4.1 1.1 1.7 0.9 0.7 0.9 2.2 2.1 1.3 14.9 0.7 0.8 1.8 2.0 13.2 1.7 4.8 0.8 1.6 8.7 0.7 1.5 29.8 0.6 3.6 7.3 3.4 0.6 2.2 2.6 8.9 1.2 20.7 1.0 1.3 13.9 3.3 2.1 0.8 48.5 37.0 81.1 47.4 13.5 28.9 35.7 61.1 28.7 41.6 40.1 88.0 100.3 120.7 63.5 24.9 53.7 52.6 54.2 33.2 50.1 81.4 24.8 224.2 27.2 44.7 4.3 121.1 39.6 15.7 6.0 47.6 36.0 19.9 44.7 84.1 117.3 102.7 51.4 23.8 181.3 65.0 86.1 77.1 33.2 104.7 74.4 67.2 37.9 63.2 50.5 53.6 45.2 35.4 15.2 57.3 93.9 40.6 28.4 51.0 47.3 29.6 60.8 21.9 45.4 187.5 20.5 86.6 67.6 1.7 0.2 0.0 0.4 0.1 0.2 0.7 1.6 0.4 0.6 0.3 0.4 0.3 1.1 0.3 0.1 0.7 6.2 0.4 0.7 1.0 0.6 1.3 0.7 0.9 0.7 0.8 0.8 0.6 1.2 0.8 1.1 3.2 0.5 1.6 5.5 6.2 3.9 5.8 5.2 1.7 3.9 6.0 4.6 32.9 4.1 7.3 0.0 17.3 6.0 4.5 3.9 3.4 7.8 5.5 8.0 3.5 1.8 34.5 3.3 1.1 35.6 5.3 6.1 9.9 0.0 21.1 3.6 1.2 11.1 0.0 2.5 9.2 2.0 0.0 5.2 3.1 1.5 3.2 0.0 2.8 3.2 2.8 3.1 1.5 1.6 2.9 3.9 1.2 17.7 3.1 8.0 9.4 2.5 1.7 0.0 3.1 7.8 48.9 49.8 9.5 4.8 7.8 5.1 4.8 16.7 3.0 CHEK2 "bA444G7, CDS1, CHK2, HuCds1, PP1425, RAD53" ENSG00000183765 "Checkpoint kinase 2" O96017 22 28687743-28742422 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Li-Fraumeni syndrome, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Spermatogonia: 31.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA001878, CAB002030" Enhanced Supported "Nucleoplasm,Golgi apparatus" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "Golgi apparatus" "CAB002030: AB_563660, HPA001878: AB_1078514" "unprognostic (1.54e-1)" "unprognostic (2.20e-1)" "unprognostic (5.83e-2)" "unprognostic (2.93e-2)" "unprognostic (2.42e-1)" "unprognostic (3.83e-2)" "unprognostic (1.49e-3)" "unprognostic (5.08e-3)" "unprognostic (3.33e-3)" "unprognostic (9.62e-3)" "unprognostic (1.28e-2)" "unprognostic (3.13e-1)" "prognostic unfavorable (7.80e-9)" "unprognostic (2.38e-2)" "unprognostic (1.78e-1)" "unprognostic (7.27e-2)" "unprognostic (6.79e-3)" 4.5 6.2 2.4 8.8 2.5 15.4 5.8 2.4 3.7 5.0 2.8 8.8 6.3 4.1 7.3 7.2 3.7 4.7 4.2 2.3 2.8 4.5 6.3 4.4 12.1 2.6 2.6 8.2 2.3 1.3 2.7 7.8 2.8 4.1 10.9 0.4 3.2 3.8 1.3 6.7 7.0 4.8 2.6 6.7 4.1 8.5 2.8 9.4 3.3 1.1 12.0 6.8 5.0 2.9 30.7 9.7 31.1 32.4 10.1 42.7 18.7 15.2 19.9 18.7 27.8 29.1 21.8 36.3 13.0 11.5 21.6 32.1 42.7 29.0 25.0 24.6 31.2 45.3 25.5 46.2 9.4 33.4 38.0 18.6 13.5 25.0 23.0 14.1 25.4 29.4 30.5 33.9 19.8 39.2 24.6 61.5 40.6 41.3 21.6 52.6 18.2 42.7 17.1 11.2 17.8 9.7 16.7 31.4 17.4 22.8 22.6 32.2 7.8 17.1 19.4 14.3 9.1 21.8 28.3 65.4 17.1 34.9 21.0 9.9 4.0 1.2 1.1 8.1 2.4 11.9 2.1 2.1 8.2 7.8 4.0 2.6 0.6 3.4 4.1 6.1 2.8 3.6 2.4 2.5 2.4 3.7 2.3 2.8 2.6 2.6 2.8 2.6 2.8 2.9 2.3 9.6 4.8 2.9 5.5 6.4 5.3 8.3 8.6 1.1 3.2 3.9 1.8 0.0 5.0 1.8 0.0 15.4 1.1 3.8 0.0 1.8 7.0 2.9 10.1 3.0 1.2 11.2 2.9 1.4 13.6 12.4 5.1 7.0 3.8 7.4 2.5 1.3 9.7 0.0 1.2 5.3 8.2 2.4 8.5 1.2 6.2 5.1 1.8 2.8 3.9 0.8 6.2 0.0 1.0 1.0 4.7 4.5 11.4 2.7 3.0 3.9 2.9 1.1 0.0 10.2 3.0 6.7 31.2 8.3 2.3 3.4 3.3 5.7 10.0 4.5 CHFR "FLJ10796, RNF196" ENSG00000072609 "Checkpoint with forkhead and ring finger domains" Q96EP1 12 132822187-132956304 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 93.8;Late spermatids: 89.1;Rod photoreceptor cells: 117.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045768, HPA073826" Approved Uncertain "Nuclear bodies,Microtubules" NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 15: RT4 - Unknown function" "Cluster 9: Photoreceptor cells - Phototransduction" "Nuclear bodies, Microtubules" "HPA045768: , HPA073826: AB_2732242" "unprognostic (1.46e-1)" "unprognostic (2.11e-2)" "unprognostic (1.41e-1)" "unprognostic (3.86e-2)" "unprognostic (2.08e-1)" "unprognostic (2.14e-3)" "unprognostic (6.56e-4)" "unprognostic (1.94e-2)" "unprognostic (2.36e-2)" "unprognostic (1.25e-1)" "unprognostic (1.00e-2)" "unprognostic (3.98e-3)" "prognostic unfavorable (4.21e-9)" "unprognostic (5.03e-1)" "unprognostic (8.46e-2)" "unprognostic (6.71e-2)" "unprognostic (1.11e-2)" 9.8 8.1 7.8 15.6 7.9 22.0 9.1 7.1 9.1 9.8 6.0 12.4 15.9 10.7 3.3 15.6 8.7 9.9 10.7 6.9 7.0 8.6 9.0 12.2 20.9 7.9 7.3 6.2 11.9 7.6 9.4 17.7 7.9 9.9 8.5 6.3 9.4 9.6 8.0 12.3 15.0 12.6 6.0 17.5 12.9 15.4 8.6 25.2 9.1 9.2 13.8 14.4 10.8 9.1 11.0 24.1 19.3 1.6 16.8 21.3 41.0 23.4 17.9 23.7 22.7 20.6 8.7 0.2 21.6 25.3 16.7 18.6 2.1 21.5 12.2 1.3 21.0 36.5 16.7 24.4 42.0 1.2 67.5 32.4 20.0 19.6 13.5 15.5 30.1 2.8 15.9 0.0 16.7 40.4 24.5 25.3 27.4 20.9 19.8 2.9 2.5 11.4 15.3 49.4 20.8 28.2 18.2 20.0 17.8 22.5 34.4 36.2 33.3 1.2 4.7 11.8 7.7 37.0 0.1 4.2 0.0 6.8 21.7 38.3 25.5 35.5 16.7 29.6 15.8 10.5 13.2 17.8 20.7 6.4 12.0 13.3 34.8 23.2 31.5 10.6 21.5 19.3 7.8 7.9 7.1 9.1 6.9 7.0 7.9 7.3 7.9 6.0 8.6 9.1 11.2 12.8 19.5 20.5 17.2 6.1 7.9 6.0 4.6 22.1 8.2 5.7 9.9 4.3 15.3 7.3 93.8 12.3 29.4 17.9 9.8 10.2 53.0 11.1 14.3 13.1 21.1 13.0 33.4 13.8 15.7 10.8 28.1 12.2 66.4 14.4 11.4 7.7 19.4 21.9 32.0 10.2 14.2 21.7 9.3 89.1 7.5 22.0 10.6 24.4 29.4 8.8 40.2 18.1 31.3 16.9 11.4 8.6 24.2 11.2 11.7 4.4 10.8 117.9 19.7 9.2 10.7 19.0 24.6 11.1 9.7 23.7 24.2 16.1 8.6 13.8 CHI3L1 "GP39, YK-40, YKL40" ENSG00000133048 "Chitinase 3 like 1" P36222 1 203178931-203186704 "Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Apoptosis, Inflammatory response" Antimicrobial "Asthma, Cancer-related genes, Schizophrenia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 232.4;brain: 239.4;liver: 447.8" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 88.7;Ductal cells: 88.9;Hepatocytes: 61.8;Hofbauer cells: 317.5" "Cancer enriched" "Detected in all" 8 "glioma: 1313.7" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 495 "neutrophil: 470.4" "Lineage enriched" "Detected in single" 495 "granulocytes: 470.4" "Cell line enhanced" "Detected in some" "ASC diff: 322.9;ASC TERT1: 712.9;HSkMC: 637.0;THP-1: 1068.4;U-138 MG: 303.5;U-87 MG: 303.7" "Low region specificity" "Detected in all" "Region enriched" "Detected in some" 10 "olfactory bulb: 16.0" HPA077365 Approved "Golgi apparatus,Vesicles" "Secreted to blood" NA NA 25100000 180000000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 15: Liver - Metabolism" "Cluster 43: THP-1 - Innate immune response" "Cluster 4: Macrophages - Innate immune response" "Golgi apparatus" Vesicles "HPA077365: " "unprognostic (2.11e-3)" "unprognostic (1.21e-1)" "unprognostic (1.29e-1)" "unprognostic (1.07e-1)" "unprognostic (6.01e-3)" "unprognostic (8.81e-2)" "unprognostic (2.09e-1)" "unprognostic (1.48e-1)" "unprognostic (4.46e-2)" "unprognostic (1.30e-1)" "unprognostic (7.98e-2)" "unprognostic (1.43e-1)" "unprognostic (1.20e-2)" "unprognostic (1.98e-2)" "unprognostic (3.43e-2)" "unprognostic (1.14e-2)" "unprognostic (9.39e-3)" 79.8 2.0 58.9 138.9 75.9 232.4 62.8 55.3 94.7 30.5 56.8 6.5 0.4 19.5 1.0 14.4 23.4 3.0 9.8 47.4 129.6 60.9 447.8 38.4 32.4 239.4 112.8 6.6 13.8 0.2 134.5 10.1 135.6 13.7 2.0 50.9 99.4 0.9 21.0 75.6 16.8 6.8 70.0 13.9 9.7 1.0 156.4 12.4 15.0 1.0 36.9 97.8 9.1 70.8 0.8 0.0 0.0 0.3 322.9 712.9 0.0 0.0 0.2 0.0 0.0 75.3 0.2 0.1 1.2 0.4 0.3 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.8 8.3 0.3 0.3 637.0 0.0 1.9 0.3 30.8 0.0 0.0 0.0 1.0 0.2 0.3 0.0 5.8 2.7 0.0 0.0 0.0 0.1 15.4 0.0 0.0 0.0 0.0 0.3 0.5 0.4 0.2 0.0 1068.4 0.0 303.5 1.6 0.0 0.4 2.3 41.9 0.3 303.7 1.2 0.2 0.0 0.4 0.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 470.4 0.0 0.9 0.0 0.0 1.3 58.9 75.9 55.3 94.7 47.4 129.6 239.4 112.8 135.6 70.0 156.4 70.8 0.7 6.4 42.8 20.5 0.1 4.2 47.1 88.7 0.0 0.1 29.8 21.5 1.0 2.8 17.3 27.6 0.0 1.3 0.6 0.0 0.0 88.9 0.0 4.8 2.2 2.1 0.0 0.4 1.1 0.0 1.1 18.6 0.0 7.2 0.0 0.0 0.0 61.8 317.5 0.0 0.1 0.0 6.1 0.8 0.4 0.0 0.9 23.7 14.2 0.0 1.0 45.1 0.0 0.0 0.1 2.0 0.0 0.0 1.4 4.2 0.0 0.2 3.4 2.8 0.0 1.0 2.3 0.0 0.0 1.5 1.1 0.8 0.9 0.0 0.0 2.2 CHIA "AMCase, CHIT2, TSA1902" ENSG00000134216 "Chitinase acidic" Q9BZP6 1 111290851-111320566 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Carbohydrate metabolism, Chitin degradation, Immunity, Inflammatory response, Polysaccharide degradation" "Glycosidase, Hydrolase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 31 "stomach 1: 327.5" "Cell type enriched" "Detected in some" 5 "Alveolar cells type 2: 34.6" "Group enriched" "Detected in some" 4 "lung cancer: 1.8;stomach cancer: 2.0;thyroid cancer: 0.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "ASC diff: 1.7" "Not detected" "Not detected" "Not detected" "Not detected" HPA059193 Approved "Intracellular and membrane" NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 4: Stomach - Digestion" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 11: Alveolar cells - Smell perception" "HPA059193: AB_2683942" "unprognostic (8.00e-2)" "unprognostic (7.08e-2)" "unprognostic (2.02e-2)" "unprognostic (4.99e-2)" "unprognostic (7.93e-2)" "unprognostic (1.46e-1)" "unprognostic (1.06e-2)" 0.3 0.2 0.1 0.0 0.2 0.0 0.1 0.1 0.3 0.2 0.0 0.0 0.0 0.6 0.5 1.6 0.3 0.0 0.1 0.1 0.1 0.1 0.2 10.6 0.3 0.2 0.1 0.1 0.2 2.0 1.9 0.0 0.1 0.0 0.0 0.0 0.1 0.5 0.0 0.1 0.0 0.0 0.1 0.0 327.5 0.5 0.1 0.0 0.5 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.3 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.2 0.0 0.0 34.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 2.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.6 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.6 0.0 0.0 CHIT1 "CHI3, CHIT" ENSG00000133063 "Chitinase 1" Q13231 1 203212827-203273641 "Candidate cardiovascular disease genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted secreted proteins" "Carbohydrate metabolism, Chitin degradation, Polysaccharide degradation" "Glycosidase, Hydrolase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 49.8;lung: 36.4;lymphoid tissue: 21.7" "Cell type enriched" "Detected in some" 10 "Hofbauer cells: 40.6" "Cancer enhanced" "Detected in many" "testis cancer: 31.9" "Region enriched" "Detected in some" 6 "cerebral cortex: 12.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA010575, HPA074844" Enhanced "Secreted to blood" NA NA 26400000 57000000 "Cluster 1: Neutrophils - Mixed function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 4: Macrophages - Innate immune response" "HPA010575: AB_1078512, HPA074844: " "unprognostic (5.80e-3)" "prognostic favorable (2.02e-4)" "unprognostic (2.58e-2)" "unprognostic (2.19e-1)" "unprognostic (7.87e-2)" "unprognostic (2.28e-2)" "unprognostic (7.55e-2)" "unprognostic (6.36e-3)" "unprognostic (1.17e-1)" "unprognostic (3.25e-2)" "unprognostic (1.38e-1)" "unprognostic (1.03e-1)" "unprognostic (1.56e-3)" "unprognostic (3.37e-1)" "unprognostic (1.52e-1)" "unprognostic (1.06e-1)" "unprognostic (2.95e-1)" 13.6 0.3 0.2 0.4 0.2 49.8 8.3 0.0 12.4 8.1 0.0 1.2 0.0 3.6 0.1 0.0 0.1 0.4 0.2 0.2 0.0 0.1 0.7 36.4 21.7 0.4 0.2 0.5 2.1 0.0 0.0 0.7 1.3 1.0 1.0 0.0 0.4 0.0 0.2 0.4 0.8 0.0 0.4 5.7 0.5 0.0 0.3 3.4 1.3 0.0 1.1 0.1 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.2 0.0 0.0 0.4 0.2 0.2 0.0 12.4 0.2 0.0 0.4 0.2 1.3 0.4 0.3 2.2 0.0 0.0 0.0 0.0 1.0 0.0 0.1 0.2 0.0 0.0 0.2 0.3 0.8 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.5 0.4 0.0 0.1 0.0 0.0 0.0 0.0 40.6 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 3.9 0.0 0.0 0.6 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.1 0.1 0.0 0.0 CHUK "IkBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16" ENSG00000213341 "Component of inhibitor of nuclear factor kappa B kinase complex" O15111 10 100188300-100229596 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001402, CAB004240, CAB018564" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" Nucleoplasm Cytosol "CAB004240: AB_627784, CAB018564: AB_649197, HPA001402: AB_1079125" "unprognostic (8.61e-3)" "unprognostic (1.70e-1)" "unprognostic (3.74e-2)" "unprognostic (3.01e-1)" "unprognostic (3.02e-2)" "unprognostic (5.93e-2)" "unprognostic (4.02e-2)" "unprognostic (2.09e-1)" "unprognostic (8.58e-2)" "unprognostic (8.39e-2)" "unprognostic (6.73e-2)" "unprognostic (1.49e-1)" "prognostic favorable (1.27e-4)" "unprognostic (2.48e-2)" "unprognostic (1.95e-1)" "unprognostic (1.88e-3)" "unprognostic (2.22e-1)" 13.5 10.3 6.6 11.7 7.6 19.6 10.8 7.1 8.3 8.4 8.3 11.9 12.8 8.8 9.1 9.7 7.5 9.0 6.8 6.4 9.2 21.0 17.0 10.2 12.7 7.3 7.5 5.6 11.5 14.0 6.5 10.5 7.6 9.6 13.3 8.0 8.8 9.0 14.2 6.9 10.8 11.8 7.7 9.9 11.2 8.3 8.7 14.3 11.1 11.7 12.6 13.6 6.4 8.7 27.7 22.9 23.0 34.4 21.6 19.3 17.6 34.3 33.5 31.3 38.0 25.9 15.9 37.2 19.7 23.5 21.8 26.7 38.7 18.2 34.9 39.8 33.5 24.7 18.0 28.7 18.4 46.2 34.8 15.5 19.1 36.2 35.0 21.8 22.7 30.1 28.5 29.9 34.6 16.7 36.9 28.4 15.0 21.8 16.5 23.7 25.5 17.0 19.9 17.6 13.7 20.3 18.6 14.2 30.9 18.0 28.5 27.8 23.9 19.6 21.9 21.5 39.7 34.9 33.7 35.7 21.3 36.9 15.8 1.0 1.2 2.1 0.9 1.9 1.5 1.6 1.1 1.6 1.4 1.0 1.3 1.5 2.8 1.8 1.3 0.8 1.2 0.5 6.6 7.6 7.1 8.3 6.4 9.2 7.3 7.5 7.6 7.7 8.7 8.7 11.4 12.8 11.5 17.9 10.8 19.8 7.1 5.1 8.0 6.3 7.3 4.8 9.2 7.2 5.9 5.5 2.1 6.5 14.1 12.2 11.7 7.1 7.6 8.9 8.6 8.4 6.0 12.0 22.7 11.8 7.8 6.5 7.7 12.7 8.2 6.2 7.1 14.4 10.6 13.5 21.3 8.0 8.2 16.9 12.7 8.0 6.2 11.7 7.2 19.7 15.6 4.5 9.2 20.6 27.7 10.4 6.0 6.0 18.5 9.6 9.5 20.0 6.4 5.0 19.7 7.8 12.0 16.4 12.9 13.2 19.0 13.8 11.1 10.1 6.6 10.6 CILK1 "ICK, KIAA0936, LCK2, MGC46090, MRK" ENSG00000112144 "Ciliogenesis associated kinase 1" Q9UPZ9 6 53001279-53061824 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cilium biogenesis/degradation" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 11.0;Cytotrophoblasts: 20.6;Extravillous trophoblasts: 33.9;Syncytiotrophoblasts: 58.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000791, HPA001113" Approved Supported "Nucleoli fibrillar center" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 24: Non-specific - Transcription regulation" "Nucleoli fibrillar center" "HPA000791: AB_2732392, HPA001113: AB_1851385" "unprognostic (1.75e-2)" "unprognostic (1.02e-1)" "unprognostic (5.47e-2)" "unprognostic (2.95e-1)" "unprognostic (2.32e-1)" "unprognostic (1.00e-2)" "unprognostic (1.44e-1)" "unprognostic (1.82e-2)" "unprognostic (1.17e-3)" "unprognostic (5.11e-2)" "unprognostic (1.18e-1)" "unprognostic (8.28e-2)" "unprognostic (8.12e-3)" "unprognostic (1.21e-1)" "unprognostic (1.39e-1)" "unprognostic (1.07e-1)" "unprognostic (2.26e-1)" 7.9 17.9 10.2 4.9 11.0 2.7 10.7 8.4 9.7 8.9 5.1 8.7 9.8 8.0 5.5 8.6 7.4 6.9 8.5 6.8 7.8 4.5 7.5 6.3 5.2 9.4 11.6 9.5 5.0 7.3 1.7 12.1 8.8 9.9 10.7 17.4 17.9 7.3 4.0 8.7 10.4 7.4 8.8 5.6 12.9 4.5 14.9 10.1 6.3 5.0 6.2 6.5 5.8 12.8 7.8 2.9 14.6 10.0 8.9 14.0 17.0 6.9 12.4 10.8 12.3 4.1 2.4 5.7 4.0 21.0 3.5 5.0 17.6 7.1 14.2 19.9 7.0 4.2 3.3 22.3 4.5 5.2 5.4 12.5 7.6 4.6 5.3 7.7 10.2 12.1 8.1 22.6 24.9 6.7 5.6 6.4 5.6 27.0 6.3 8.8 6.5 7.5 4.5 5.6 23.6 10.6 6.7 16.3 9.6 14.2 9.5 10.9 8.5 17.2 8.0 6.5 17.1 6.3 4.8 2.2 3.5 5.0 8.5 2.8 1.0 2.2 1.7 0.8 1.5 1.2 1.2 1.4 1.0 1.5 1.4 1.2 0.5 1.1 0.9 1.4 1.7 0.8 10.2 11.0 8.4 9.7 6.8 7.8 9.4 11.6 8.8 8.8 14.9 12.8 6.3 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.0 0.0 0.0 0.0 0.0 20.6 5.7 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 33.9 5.3 0.0 0.0 0.0 0.0 0.0 0.0 6.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.2 0.0 0.0 0.0 0.0 58.1 0.8 0.0 0.0 0.0 CIT "CITK, CRIK, KIAA0949, STK21" ENSG00000122966 "Citron rho-interacting serine/threonine kinase" O14578 12 119685791-119877320 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Differentiation, Mitosis, Neurogenesis" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Primary microcephaly" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 26.2" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 87.6;Early spermatids: 72.8;Excitatory neurons: 147.0;Inhibitory neurons: 139.8;Oligodendrocyte precursor cells: 82.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019082, HPA048812, HPA075506" Uncertain Approved Cytosol NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "HPA019082: AB_1846803, HPA048812: AB_2680528, HPA075506: AB_2686752" "unprognostic (5.64e-2)" "unprognostic (5.00e-2)" "unprognostic (8.16e-2)" "unprognostic (5.12e-3)" "unprognostic (1.25e-1)" "unprognostic (3.55e-2)" "unprognostic (3.61e-6)" "unprognostic (6.02e-2)" "unprognostic (7.78e-2)" "unprognostic (4.42e-1)" "unprognostic (1.37e-3)" "unprognostic (4.88e-2)" "unprognostic (2.55e-3)" "unprognostic (8.56e-2)" "unprognostic (1.50e-1)" "unprognostic (1.70e-1)" "unprognostic (3.30e-1)" 0.7 2.2 13.5 1.6 26.2 6.3 0.6 0.0 19.9 0.9 0.0 2.1 1.2 0.4 0.0 2.5 0.5 0.5 0.6 15.2 5.4 2.5 0.3 1.8 1.5 0.2 5.0 0.3 0.2 0.1 1.6 1.4 0.4 0.5 2.5 3.4 0.8 0.2 0.5 1.6 1.9 0.9 0.9 3.0 2.2 4.8 14.2 6.8 0.6 0.3 2.3 0.5 1.3 6.6 26.2 20.6 21.7 15.3 2.4 6.3 10.4 22.0 19.1 21.8 16.6 14.5 10.3 18.4 10.0 14.2 9.3 14.6 14.4 9.5 32.1 13.6 7.5 25.7 13.2 7.1 0.3 12.7 20.6 0.9 1.2 23.7 14.8 7.3 15.5 19.9 14.5 15.2 19.5 12.2 22.4 14.0 10.4 8.7 12.5 19.3 39.8 6.3 5.0 11.1 15.5 8.4 31.9 6.5 16.0 9.6 23.2 10.6 11.5 21.9 21.4 17.2 22.7 9.9 12.6 14.2 16.8 12.5 35.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 13.5 26.2 0.0 19.9 15.2 5.4 0.2 5.0 0.4 0.9 14.2 6.6 4.1 6.4 13.0 8.5 1.2 3.3 0.7 1.0 0.6 8.2 1.8 1.5 1.8 0.0 5.6 9.2 87.6 3.5 0.6 1.1 0.0 0.2 72.8 2.4 2.1 2.7 1.8 12.8 147.0 0.8 4.8 2.2 3.1 3.6 1.3 10.5 1.1 0.7 3.6 0.0 139.8 4.4 6.1 3.7 0.8 44.1 1.2 2.0 3.6 7.5 0.0 15.4 1.0 82.4 18.7 0.2 0.1 1.2 4.1 0.4 0.8 7.5 1.7 15.2 0.0 0.6 3.3 33.2 4.2 7.7 1.3 1.0 2.2 4.3 4.4 1.0 CLK1 ENSG00000013441 "CDC like kinase 1" P49759 2 200853009-200864744 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033141, HPA062405" Approved Supported "Nucleoplasm,Nuclear membrane" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 2: Karpas-707 - Immune response" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Nuclear membrane" "CAB033141: AB_1121713, HPA062405: AB_2684753" "unprognostic (9.79e-2)" "unprognostic (2.05e-1)" "unprognostic (2.15e-2)" "unprognostic (1.63e-1)" "unprognostic (9.19e-2)" "unprognostic (4.50e-3)" "unprognostic (1.52e-1)" "unprognostic (2.77e-3)" "unprognostic (1.78e-2)" "unprognostic (2.09e-2)" "unprognostic (1.09e-2)" "unprognostic (5.63e-3)" "unprognostic (2.03e-3)" "unprognostic (9.66e-2)" "unprognostic (2.30e-1)" "unprognostic (1.18e-1)" "prognostic favorable (2.28e-4)" 89.6 82.7 132.9 25.4 137.1 178.0 72.2 140.9 201.6 118.5 136.2 78.3 20.8 65.8 51.1 58.5 85.5 56.5 83.9 133.9 137.7 83.3 84.4 90.3 55.9 138.1 133.4 140.3 63.6 29.0 82.3 64.8 138.6 109.7 24.2 133.8 68.9 49.6 80.4 62.5 51.6 30.9 135.2 113.0 53.2 28.1 134.1 76.0 92.5 71.4 42.0 77.8 112.8 176.0 17.9 13.5 22.6 6.5 24.4 26.1 17.1 19.2 26.8 19.3 25.5 24.6 11.8 5.5 13.1 11.4 11.1 19.7 27.9 8.8 38.2 27.3 24.0 18.1 35.9 30.7 14.7 19.5 31.1 12.3 39.9 23.4 41.8 20.6 11.4 9.5 23.3 77.1 27.0 12.3 23.0 58.4 13.9 11.4 29.8 24.8 25.7 31.8 13.0 11.2 22.0 17.8 16.4 6.1 32.7 12.9 5.3 13.2 19.5 21.4 14.8 21.5 22.0 46.8 20.9 13.7 14.2 15.4 14.9 40.0 7.2 18.6 14.5 5.0 17.3 17.4 15.7 15.8 4.8 11.7 15.6 12.9 16.9 9.5 6.0 11.1 17.2 10.4 132.9 137.1 140.9 201.6 133.9 137.7 138.1 133.4 138.6 135.2 134.1 176.0 122.1 44.8 85.4 112.0 164.2 168.8 263.0 73.6 114.4 59.0 112.9 97.0 96.6 41.5 87.1 27.6 100.1 46.7 213.5 110.9 19.6 31.4 2.3 111.2 108.8 113.6 134.3 87.5 51.7 26.9 56.6 142.5 81.1 173.6 136.9 77.9 82.1 43.3 58.5 52.2 53.6 124.2 50.8 100.5 285.8 9.4 92.9 192.3 154.7 62.8 56.2 54.6 76.2 58.3 169.0 32.0 117.7 75.6 169.0 133.3 88.2 14.9 70.1 99.6 111.7 97.8 128.4 33.1 27.7 117.0 151.7 90.3 261.2 43.0 88.6 184.2 CLK2 ENSG00000176444 "CDC like kinase 2" P49760 1 155262868-155278491 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA055366, HPA059507" Approved Enhanced "Nucleoplasm,Nuclear bodies" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 29: U-266 - Adaptive immune response" "Cluster 43: Cardiomyocytes - Nuclear processes" Nucleoplasm "Nuclear bodies" "HPA055366: AB_2682795, HPA059507: AB_2684044" "unprognostic (2.00e-2)" "unprognostic (1.35e-2)" "prognostic unfavorable (3.77e-4)" "unprognostic (2.84e-2)" "unprognostic (3.16e-1)" "unprognostic (1.75e-1)" "prognostic unfavorable (2.82e-4)" "unprognostic (2.38e-1)" "unprognostic (2.36e-1)" "unprognostic (1.36e-2)" "unprognostic (7.66e-2)" "unprognostic (3.84e-2)" "prognostic unfavorable (2.95e-9)" "unprognostic (1.70e-1)" "unprognostic (1.40e-1)" "unprognostic (1.11e-1)" "prognostic favorable (5.43e-4)" 23.7 25.6 11.6 10.7 11.9 11.4 24.4 14.2 14.4 39.2 14.1 24.1 11.7 29.8 12.7 22.6 28.7 9.6 18.5 11.7 12.7 26.8 29.0 22.0 19.6 12.3 11.7 33.9 23.9 14.0 31.4 13.8 12.4 33.1 8.7 9.4 23.3 11.2 16.2 27.5 24.0 10.9 11.7 40.1 20.8 16.2 12.4 18.6 33.2 8.5 15.9 28.1 29.9 13.2 10.8 10.5 29.8 11.4 17.3 9.1 22.5 8.1 12.3 8.2 7.8 13.1 8.7 23.3 9.7 6.6 4.0 17.0 16.8 13.5 6.3 11.4 17.7 20.4 12.9 15.4 14.6 26.8 20.5 7.6 10.7 11.3 20.3 19.0 13.6 16.9 29.6 15.4 10.5 22.2 12.1 11.3 21.2 27.2 17.6 17.7 21.6 28.0 17.9 25.8 11.8 25.1 4.5 10.9 9.9 21.4 15.9 24.9 9.3 4.3 12.1 9.1 9.1 31.6 28.6 22.9 9.9 19.1 5.9 0.5 0.8 1.9 0.8 0.4 1.6 1.2 1.5 0.8 0.9 0.9 1.6 1.6 0.8 0.5 0.4 0.8 0.9 0.6 11.6 11.9 14.2 14.4 11.7 12.7 12.3 11.7 12.4 11.7 12.4 13.2 9.2 16.0 24.3 9.8 13.7 4.6 5.7 4.2 17.6 5.7 7.8 7.5 14.9 12.8 12.6 7.3 4.2 8.0 7.1 5.4 0.0 6.5 6.5 6.9 15.2 11.1 6.7 8.4 8.3 4.4 8.0 11.3 25.0 9.5 10.1 12.1 7.5 8.4 6.9 5.0 6.8 9.1 2.0 11.4 4.5 6.6 7.8 10.4 3.6 9.4 9.5 5.4 8.2 9.5 8.0 4.9 4.8 3.0 17.1 5.7 5.1 3.2 5.1 7.2 6.6 6.4 12.6 8.6 4.3 14.3 4.5 12.4 11.0 7.4 7.2 5.1 CLK3 ENSG00000179335 "CDC like kinase 3" P49761 15 74598500-74645414 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046817 Approved Supported "Nucleoplasm,Intermediate filaments" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 30: Epithelial cell lines - Translation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "Intermediate filaments" "HPA046817: AB_10964124" "unprognostic (4.10e-2)" "unprognostic (8.43e-2)" "prognostic unfavorable (2.05e-6)" "unprognostic (1.91e-3)" "unprognostic (7.91e-2)" "unprognostic (5.76e-2)" "unprognostic (1.46e-1)" "unprognostic (1.30e-2)" "unprognostic (1.95e-1)" "unprognostic (2.54e-1)" "unprognostic (8.14e-3)" "prognostic unfavorable (5.92e-4)" "unprognostic (1.35e-2)" "unprognostic (2.24e-1)" "unprognostic (9.73e-2)" "unprognostic (2.48e-1)" "unprognostic (2.25e-2)" 35.9 28.7 30.3 26.5 31.8 112.4 34.6 36.4 35.9 36.7 32.8 36.6 28.9 32.3 25.9 38.6 31.3 32.7 28.3 30.2 31.2 30.0 29.4 34.0 37.7 32.8 31.6 38.4 33.9 35.3 32.3 31.6 32.5 31.9 21.8 33.1 36.1 29.7 50.7 41.7 33.7 26.2 29.5 41.7 35.1 44.4 32.2 55.8 32.3 52.1 30.3 37.8 33.8 35.4 56.7 35.1 45.5 25.6 57.2 43.4 35.8 37.7 59.2 52.7 64.3 47.9 36.4 51.2 27.2 33.9 73.5 39.0 85.4 36.3 34.3 73.2 46.9 63.0 52.0 33.6 90.7 17.2 46.6 54.8 71.0 69.4 57.4 64.0 58.6 51.0 31.3 36.2 31.1 39.9 50.9 57.3 29.1 55.7 24.6 40.7 21.8 33.7 41.1 40.3 25.5 29.9 30.2 33.0 34.3 34.7 31.4 33.8 27.3 31.0 23.7 19.7 50.2 59.0 51.8 42.2 27.2 82.4 40.1 74.2 65.5 90.0 68.9 74.1 68.2 71.0 73.6 71.9 61.3 78.8 74.4 70.9 115.9 90.7 97.7 69.5 87.7 85.9 30.3 31.8 36.4 35.9 30.2 31.2 32.8 31.6 32.5 29.5 32.2 35.4 29.8 6.4 38.4 14.0 34.1 44.9 44.9 41.6 26.2 35.5 22.8 15.9 18.6 28.6 35.1 12.9 56.3 27.7 41.8 46.7 31.3 34.2 83.6 25.8 19.9 28.6 29.3 31.5 6.6 24.2 46.2 24.5 37.8 41.5 21.5 27.4 21.4 13.4 27.5 28.6 7.9 34.7 42.7 23.3 34.4 19.8 27.7 28.4 28.4 6.5 29.5 18.0 29.9 7.1 9.6 30.8 52.0 20.3 26.6 38.9 35.5 18.6 23.4 42.6 13.1 20.4 35.8 45.4 21.4 21.0 41.9 58.6 40.1 20.4 28.1 63.5 CLK4 ENSG00000113240 "CDC like kinase 4" Q9HAZ1 5 178602664-178630615 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 5 "Early spermatids: 297.5;Late spermatids: 518.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043746 Approved Approved "Actin filaments" No No "Cluster 5: Granulocytes - Unknown function" "Cluster 54: Non-specific - Microtubule organization" "Cluster 20: HeLa - Mitochondria" "Cluster 34: Spermatids - Unknown function" "Actin filaments" "HPA043746: AB_2678650" "unprognostic (9.46e-2)" "unprognostic (2.24e-2)" "unprognostic (1.48e-1)" "unprognostic (3.44e-2)" "unprognostic (1.59e-1)" "unprognostic (7.16e-3)" "unprognostic (2.67e-1)" "unprognostic (2.04e-2)" "unprognostic (4.37e-2)" "unprognostic (5.92e-2)" "unprognostic (2.90e-3)" "unprognostic (9.62e-3)" "unprognostic (1.13e-2)" "unprognostic (1.26e-1)" "unprognostic (3.38e-1)" "unprognostic (1.20e-1)" "unprognostic (1.14e-3)" 13.8 11.9 14.0 7.8 14.9 10.4 13.6 22.9 20.1 20.1 14.0 14.4 9.4 12.8 11.9 10.1 13.7 9.8 13.0 14.1 14.5 13.4 13.7 10.8 17.6 15.0 14.0 18.3 17.6 7.9 10.3 10.8 15.2 16.7 6.6 34.4 13.0 8.3 17.8 15.1 12.6 5.5 14.0 18.6 12.5 15.2 14.2 16.6 16.6 21.1 10.0 12.5 21.0 19.3 8.1 7.2 6.8 10.0 19.9 15.9 11.2 7.6 8.8 4.5 8.4 7.7 6.6 4.6 6.0 3.2 5.2 10.4 8.9 6.0 7.5 16.8 6.8 1.8 15.2 8.8 7.4 3.8 5.7 7.2 8.8 7.6 9.6 15.1 3.2 3.1 4.1 13.4 5.5 3.3 5.2 13.8 3.4 5.4 4.5 4.8 6.0 6.7 4.2 2.3 7.4 5.0 8.4 4.7 8.4 3.8 5.1 8.0 6.9 9.5 3.4 4.9 8.4 8.4 3.5 3.5 6.8 9.0 5.0 7.7 5.9 12.7 8.9 4.1 12.6 12.8 9.5 8.4 5.9 10.2 12.2 9.5 16.1 8.4 4.3 7.4 9.6 4.9 14.0 14.9 22.9 20.1 14.1 14.5 15.0 14.0 15.2 14.0 14.2 19.3 31.9 16.0 27.8 45.7 57.8 31.9 44.5 18.4 40.9 70.8 23.5 21.6 22.9 11.5 23.7 14.7 39.6 20.1 52.1 12.2 5.9 9.4 297.5 22.8 30.1 25.4 6.0 38.7 79.6 4.7 18.4 29.2 20.4 19.8 27.9 36.1 18.9 13.0 10.1 28.6 40.5 10.7 14.2 13.9 24.7 518.3 30.7 21.4 16.0 43.1 18.3 29.6 27.8 61.9 60.6 7.2 16.5 29.3 36.5 23.9 25.0 10.1 26.8 81.3 19.7 17.1 30.9 30.3 18.4 19.7 24.6 15.9 42.0 24.1 10.2 26.9 CLOCK "bHLHe8, KAT13D, KIAA0334" ENSG00000134852 "Clock circadian regulator" O15516 4 55427903-55546909 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transcription factors" "Biological rhythms, DNA damage, Transcription, Transcription regulation" "Activator, Acyltransferase, DNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001867, HPA027565" Supported Enhanced Nucleoplasm,Vesicles NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 23: Testis - Cell cycle regulation" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 52: Non-specific - Transcription" Nucleoplasm Vesicles "HPA001867: AB_1078537, HPA027565: AB_1846975" "unprognostic (1.30e-2)" "unprognostic (9.02e-2)" "unprognostic (4.25e-3)" "unprognostic (2.48e-1)" "unprognostic (3.94e-2)" "unprognostic (2.00e-2)" "unprognostic (1.17e-1)" "unprognostic (1.30e-1)" "unprognostic (4.52e-2)" "unprognostic (4.32e-2)" "unprognostic (3.01e-2)" "unprognostic (5.96e-2)" "unprognostic (4.07e-2)" "unprognostic (8.31e-2)" "unprognostic (1.69e-1)" "unprognostic (5.18e-2)" "unprognostic (7.16e-2)" 5.5 6.1 3.7 4.2 4.2 1.3 5.9 8.9 5.4 8.0 5.5 5.1 4.9 6.9 5.7 9.2 5.3 4.3 7.5 4.7 5.3 6.5 5.5 4.6 2.9 2.8 3.7 6.2 5.1 10.3 5.5 5.5 3.3 6.2 5.7 11.6 4.6 6.1 9.8 6.8 5.6 7.1 3.8 4.5 6.9 14.1 3.8 3.0 10.1 9.2 3.7 5.6 6.8 5.0 20.0 9.1 7.5 11.6 11.8 11.5 3.6 18.7 16.4 12.9 12.7 5.1 14.8 5.1 9.9 22.8 10.3 15.9 9.5 15.4 23.2 6.9 3.1 4.4 9.4 6.7 10.3 7.0 4.7 6.7 15.8 18.8 18.7 10.4 13.1 4.6 10.1 10.1 21.3 10.6 4.0 4.1 5.0 16.3 9.4 2.5 8.7 3.3 11.0 10.9 7.6 6.2 13.5 16.7 8.9 6.2 5.7 4.2 17.1 18.4 19.5 6.0 26.6 9.1 7.5 3.1 15.6 5.8 14.6 0.0 0.7 0.2 0.7 0.7 1.3 0.4 0.9 0.8 1.1 0.7 0.4 0.6 0.2 0.9 0.7 0.5 0.9 0.4 3.7 4.2 8.9 5.4 4.7 5.3 2.8 3.7 3.3 3.8 3.8 5.0 32.2 41.7 27.7 49.3 15.2 31.1 21.8 28.5 27.9 63.4 21.5 14.9 55.2 14.3 27.4 14.7 43.8 11.3 11.9 21.5 1.9 13.6 34.5 34.2 39.9 32.1 39.7 3.8 95.9 16.5 6.8 28.0 25.0 32.0 3.8 16.6 28.9 27.7 11.6 33.7 114.6 18.5 18.3 17.0 26.1 16.9 23.9 16.9 10.6 70.3 14.0 26.7 19.6 82.0 93.1 28.3 13.2 36.1 18.5 34.0 29.6 19.7 25.2 41.4 13.1 36.5 28.2 64.9 72.5 55.1 37.5 5.2 14.0 21.7 15.6 51.6 CLPS ENSG00000137392 Colipase P04118 6 35794982-35797344 "Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Digestion, Lipid degradation, Lipid metabolism" "Diabetes mellitus" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 1696 "pancreas: 262086.0" "Cell type enriched" "Detected in some" 17 "Exocrine glandular cells: 23175.0" "Cancer enriched" "Detected in many" 188 "pancreatic cancer: 1726.0" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA010512 Enhanced "Secreted to digestive system" NA NA 1600000 "Cluster 15: NK-cells - Transcription" "Cluster 25: Pancreas - Digestion" "Cluster 1: Pancreatic cells - Digestion" "HPA010512: AB_1846979" "unprognostic (2.00e-1)" "unprognostic (1.11e-1)" "unprognostic (8.12e-3)" "unprognostic (2.47e-1)" "unprognostic (1.33e-1)" "unprognostic (1.61e-1)" 30.4 6.1 0.9 5.8 1.8 9.0 17.8 0.1 0.7 13.4 0.2 6.8 40.2 6.0 5.6 9.9 3.8 0.0 46.3 1.2 0.1 5.5 17.7 4.1 10.5 0.2 0.2 154.4 262086.0 0.0 6.3 11.9 0.3 7.9 0.0 0.0 41.7 0.0 5.8 8.1 24.0 0.0 0.1 7.9 27.7 4.0 0.6 0.0 3.8 0.0 0.0 3.3 5.1 0.6 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.8 0.0 0.2 0.0 0.6 0.3 0.0 0.2 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.5 0.2 0.0 0.0 0.0 0.0 0.9 1.8 0.1 0.7 1.2 0.1 0.2 0.2 0.3 0.1 0.6 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 28.6 0.0 0.0 0.0 1.1 11.9 0.0 0.0 23175.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.7 0.0 0.0 130.8 0.0 0.0 0.0 0.0 1331.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.8 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CMA1 ENSG00000092009 "Chymase 1" P23946 14 24505353-24508265 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "breast: 18.5" "Cell type enriched" "Detected in some" 28 "granulocytes: 53.8" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB000363, HPA052634" Enhanced Supported "Cytosol,Cytoplasmic bodies" "Secreted to blood" NA NA 3000000 "Cluster 35: T-regs - Unknown function" "Cluster 46: Fibroblasts - ECM organization" "Cluster 60: Granulocytes - Receptor signaling" "Cytoplasmic bodies" Cytosol "CAB000363: AB_2083616, HPA052634: AB_2681892" "unprognostic (1.37e-1)" "unprognostic (2.27e-3)" "unprognostic (2.04e-1)" "unprognostic (7.07e-3)" "unprognostic (1.48e-2)" "unprognostic (1.19e-1)" "unprognostic (5.79e-2)" "unprognostic (2.21e-1)" "unprognostic (8.91e-3)" "unprognostic (4.19e-3)" "unprognostic (1.29e-4)" "unprognostic (2.52e-3)" "unprognostic (7.78e-2)" "unprognostic (7.37e-2)" "unprognostic (4.98e-3)" 9.0 0.0 0.2 3.7 0.1 0.2 18.5 0.0 0.2 4.6 0.3 8.7 0.6 3.1 4.3 10.2 0.9 7.3 1.6 0.1 0.2 0.2 0.5 1.5 1.8 0.5 0.3 0.1 1.6 0.6 0.2 0.1 0.3 1.0 8.3 0.0 4.7 1.3 0.9 9.0 5.8 2.2 0.3 0.2 1.5 0.9 0.2 3.0 0.4 3.0 2.4 11.1 0.9 0.2 0.0 0.0 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.2 0.2 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.5 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.1 0.0 0.2 0.1 0.2 0.5 0.3 0.3 0.3 0.2 0.2 0.0 0.0 1.9 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 53.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.1 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.4 0.0 0.7 0.0 0.1 0.0 CMTR1 "FTSJD2, ISG95, KIAA0082, MTr1" ENSG00000137200 "Cap methyltransferase 1" Q8N1G2 6 37433219-37482827 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "mRNA capping, mRNA processing" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 253.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029954, HPA029979, HPA029980" Enhanced Enhanced Nucleoplasm,Vesicles NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 71: Testis - DNA repair" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 52: Non-specific - Transcription" Nucleoplasm Vesicles "HPA029954: AB_10670558, HPA029979: AB_10671363, HPA029980: AB_10671094" "unprognostic (1.33e-1)" "unprognostic (2.12e-2)" "unprognostic (6.43e-2)" "prognostic unfavorable (1.73e-5)" "unprognostic (1.00e-1)" "unprognostic (3.72e-1)" "unprognostic (1.68e-2)" "unprognostic (6.43e-3)" "unprognostic (2.95e-2)" "unprognostic (9.17e-2)" "unprognostic (5.24e-3)" "unprognostic (1.50e-3)" "unprognostic (3.00e-3)" "unprognostic (3.27e-2)" "unprognostic (9.72e-2)" "unprognostic (2.54e-1)" "unprognostic (1.14e-2)" 20.1 22.1 21.0 19.2 21.2 30.9 19.5 20.3 22.9 23.6 18.6 26.8 18.1 23.1 17.4 16.9 22.4 15.1 25.1 20.7 22.0 19.4 21.8 20.4 25.3 21.5 21.0 28.0 22.1 27.5 26.0 24.9 20.3 21.9 15.2 28.5 21.7 18.4 30.1 23.2 23.2 20.4 20.2 28.8 21.9 62.9 23.5 30.9 20.3 23.4 25.6 21.6 20.0 20.2 23.5 21.9 31.0 50.7 34.2 31.1 37.4 27.5 37.7 68.1 75.9 33.3 15.3 48.6 30.5 40.7 63.8 25.7 39.7 28.4 51.7 33.8 35.2 26.8 26.8 37.2 26.3 38.9 17.6 27.1 20.9 37.6 26.7 35.7 32.2 44.3 60.6 34.5 36.3 38.5 49.8 34.6 15.6 15.7 20.7 39.0 36.7 28.1 22.0 28.2 34.2 25.6 30.8 23.4 40.2 22.1 39.8 29.7 30.0 40.7 30.3 16.3 31.1 39.3 21.8 253.0 16.0 40.1 45.6 4.2 5.4 3.5 4.9 7.1 4.1 5.5 4.3 5.2 5.1 3.8 4.7 3.9 3.3 5.6 5.5 4.2 6.1 4.6 21.0 21.2 20.3 22.9 20.7 22.0 21.5 21.0 20.3 20.2 23.5 20.2 11.3 9.6 9.2 5.9 12.0 3.6 3.9 4.0 8.6 14.2 6.3 5.5 10.4 8.6 11.5 7.3 33.3 18.0 15.4 5.3 0.0 4.5 20.2 7.7 15.4 9.6 8.4 6.5 15.1 8.5 8.0 8.8 11.7 8.9 3.8 24.9 7.9 10.1 7.5 11.8 13.9 8.4 4.1 7.5 2.3 11.3 7.8 9.5 3.6 14.0 11.5 8.8 7.2 10.6 14.2 8.5 3.3 6.8 12.4 4.3 4.7 4.0 11.2 11.9 6.6 8.5 13.5 16.8 10.6 5.8 4.7 20.8 11.5 22.0 6.9 3.6 CNDP1 "CN1, CPGL2, HsT2308, MGC10825" ENSG00000150656 "Carnosine dipeptidase 1" Q96KN2 18 74534500-74587212 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "brain: 85.6" "Cell type enriched" "Detected in some" 10 "Oligodendrocytes: 361.7" "Cancer enhanced" "Detected in some" "glioma: 4.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 38 "U-266/84: 15.4" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA008933, HPA073283" Enhanced "Secreted to blood" NA NA 2100000000 "Cluster 70: Brain - Nervous system development" "Cluster 16: U-266 - Nucleosome" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA008933: AB_1847033, HPA073283: " "unprognostic (7.43e-3)" "unprognostic (6.00e-2)" "unprognostic (8.55e-3)" "unprognostic (3.93e-1)" "unprognostic (1.32e-1)" "unprognostic (2.17e-2)" "unprognostic (8.04e-3)" "unprognostic (1.12e-2)" "unprognostic (2.81e-1)" "unprognostic (1.16e-1)" "unprognostic (1.16e-1)" "unprognostic (1.66e-1)" "unprognostic (6.90e-3)" "unprognostic (1.14e-1)" "unprognostic (3.30e-2)" "unprognostic (1.33e-1)" "unprognostic (1.28e-1)" 0.0 0.0 27.4 0.0 74.2 0.1 0.0 80.4 39.0 0.0 6.0 0.0 1.3 0.0 0.7 0.0 0.0 0.1 0.0 30.5 51.3 0.5 12.9 0.0 0.0 85.6 76.9 0.0 0.0 0.0 0.2 0.0 74.3 0.1 0.0 0.1 0.0 0.1 1.4 0.1 0.2 0.0 39.7 0.0 0.0 0.3 74.9 0.0 0.2 0.0 0.0 0.0 0.0 80.7 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 15.4 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 27.4 74.2 80.4 39.0 30.5 51.3 85.6 76.9 74.3 39.7 74.9 80.7 0.2 0.0 0.0 0.3 0.2 0.1 0.4 0.2 0.0 0.6 0.5 0.3 0.7 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.1 8.6 0.5 0.2 0.2 0.0 2.7 1.2 0.2 0.0 0.3 0.0 1.5 0.0 0.2 0.7 35.1 0.1 0.0 1.5 0.7 0.0 1.2 1.1 3.1 0.0 0.2 0.0 1.0 0.0 0.5 0.0 3.0 361.7 0.2 0.1 0.0 0.0 0.4 0.4 24.5 0.0 1.0 0.0 0.6 0.2 1.0 0.4 0.0 0.3 0.0 0.4 0.0 0.5 0.2 CNDP2 "CN2, CPGL, FLJ10830, HsT2298, PEPA" ENSG00000133313 "Carnosine dipeptidase 2" Q96KP4 18 74495816-74523454 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Glandular and luminal cells: 334.7;Proximal enterocytes: 629.1;Proximal tubular cells: 487.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Karpas-707: 458.7;RPMI-8226: 616.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB026196, HPA036898, HPA036899" Enhanced Enhanced Nucleoplasm,Cytosol NA NA 2600000 "Cluster 27: Non-specific - Gene expression" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 2: Karpas-707 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nucleoplasm, Cytosol" "CAB026196: , HPA036898: AB_2675370, HPA036899: AB_2675371" "unprognostic (2.81e-2)" "unprognostic (9.96e-2)" "unprognostic (3.28e-1)" "unprognostic (1.19e-3)" "unprognostic (2.57e-2)" "unprognostic (5.06e-2)" "unprognostic (2.84e-2)" "unprognostic (5.35e-2)" "unprognostic (1.49e-1)" "unprognostic (9.31e-2)" "unprognostic (1.56e-3)" "unprognostic (1.15e-1)" "prognostic favorable (3.50e-6)" "unprognostic (2.37e-3)" "unprognostic (4.65e-3)" "unprognostic (1.51e-1)" "unprognostic (1.34e-1)" 54.8 40.7 125.3 75.0 147.0 25.1 60.4 139.4 156.9 136.8 113.0 83.6 190.1 44.2 122.8 78.4 140.8 94.4 63.7 123.7 133.2 327.3 261.1 82.3 86.3 143.1 137.4 34.4 100.7 58.5 48.0 75.4 144.7 122.5 79.5 42.1 57.4 101.7 26.6 47.0 255.0 37.9 140.4 137.0 103.5 20.9 143.9 52.5 159.1 22.4 82.2 94.5 47.4 157.6 64.6 85.0 60.5 57.4 72.2 42.5 252.3 66.0 61.7 88.3 87.4 49.6 67.1 80.3 81.4 72.1 69.0 95.0 92.7 124.9 62.7 121.3 36.7 80.2 42.1 79.6 104.6 158.7 119.3 64.5 93.9 76.4 136.6 50.1 78.3 94.6 86.3 458.7 59.1 71.6 84.9 75.6 91.0 42.4 50.3 91.3 69.4 616.6 346.1 264.1 65.3 34.2 51.6 360.2 91.6 143.0 151.5 64.0 82.5 93.9 79.5 21.2 45.2 85.5 380.6 108.1 63.6 113.8 80.2 37.1 115.4 49.0 77.6 166.3 84.4 102.4 61.6 72.2 185.1 110.5 65.5 72.4 15.9 124.6 174.1 161.3 94.5 135.7 125.3 147.0 139.4 156.9 123.7 133.2 143.1 137.4 144.7 140.4 143.9 157.6 39.2 73.7 62.7 16.6 55.7 9.2 40.3 48.6 12.5 33.6 76.5 36.4 26.9 77.2 56.8 119.5 16.7 157.9 47.8 99.0 187.9 168.1 3.3 187.7 49.7 49.6 65.3 23.3 8.8 154.7 130.9 23.5 63.7 334.7 12.0 34.0 40.0 119.8 216.3 43.7 10.8 82.9 75.3 122.9 24.9 4.1 18.6 79.0 17.8 13.1 90.8 86.6 55.6 15.6 51.7 108.9 103.5 16.6 44.4 65.2 629.1 487.6 73.3 31.6 13.1 15.2 22.3 8.3 7.2 27.1 9.7 109.0 38.2 32.8 99.8 53.8 CNOT4 "CLONE243, NOT4, NOT4H" ENSG00000080802 "CCR4-NOT transcription complex subunit 4" O95628 7 135361795-135510127 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transcription factors" "Ubl conjugation pathway" "RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005737 Approved NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" "HPA005737: AB_1078544" "unprognostic (9.11e-2)" "unprognostic (2.12e-1)" "unprognostic (1.30e-1)" "unprognostic (5.47e-2)" "unprognostic (3.61e-1)" "unprognostic (1.64e-2)" "prognostic unfavorable (1.19e-4)" "unprognostic (2.82e-2)" "unprognostic (4.18e-2)" "prognostic favorable (1.61e-4)" "unprognostic (9.08e-2)" "unprognostic (1.00e-2)" "prognostic favorable (7.67e-6)" "unprognostic (1.01e-1)" "unprognostic (6.31e-2)" "unprognostic (2.23e-1)" "unprognostic (9.33e-2)" 9.2 8.9 10.3 8.2 11.0 7.9 8.3 16.2 14.0 11.3 5.9 8.7 7.4 11.1 9.1 10.1 10.4 8.9 12.5 10.7 13.7 10.0 10.4 8.7 10.1 9.4 10.6 15.4 9.2 13.4 6.5 10.7 9.4 9.5 8.4 15.4 11.4 9.4 21.7 10.2 7.7 11.0 7.7 9.5 8.1 17.6 10.2 11.9 13.6 22.2 11.5 9.0 8.7 11.2 15.4 14.3 14.3 19.3 23.3 18.4 10.3 16.9 18.3 14.1 17.4 12.4 15.4 15.2 14.3 15.6 20.0 14.2 18.3 12.8 20.0 17.3 14.1 12.6 11.9 11.0 12.9 14.4 14.5 14.2 16.0 18.1 11.1 16.2 14.7 10.7 22.4 11.8 21.0 19.2 19.8 21.2 18.9 14.1 11.9 12.7 14.1 16.6 16.6 14.0 15.1 17.7 19.7 21.7 11.6 13.2 13.5 15.8 20.0 17.0 10.0 15.9 18.5 18.1 18.2 21.5 17.2 16.4 23.2 23.7 10.5 14.6 12.4 10.8 13.6 9.8 10.4 10.4 9.4 10.7 11.1 10.5 9.4 15.8 13.1 7.5 9.7 9.2 10.3 11.0 16.2 14.0 10.7 13.7 9.4 10.6 9.4 7.7 10.2 11.2 53.9 22.4 43.0 83.9 63.0 67.7 76.3 54.0 45.5 50.6 49.7 58.2 42.7 31.5 44.3 36.8 106.3 31.5 60.9 30.0 70.5 32.9 30.7 31.3 56.7 48.3 40.7 50.9 103.7 20.7 22.5 58.4 35.2 45.1 62.6 46.1 40.0 25.0 25.5 55.5 94.0 30.2 30.5 28.1 61.0 20.7 65.3 33.4 42.7 88.1 61.0 69.1 68.0 119.6 102.8 32.4 31.2 69.2 58.9 73.0 32.0 56.2 35.4 72.4 19.7 83.8 75.3 113.4 75.7 42.1 75.7 44.6 61.6 45.9 29.3 89.4 CNP ENSG00000173786 "2',3'-cyclic nucleotide 3' phosphodiesterase" P09543 17 41966763-41977740 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, RNA-binding" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 7 "brain: 1395.7" "Cell type enriched" "Detected in all" 4 "Oligodendrocytes: 555.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "plasmacytoid DC: 149.4" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Region enriched" "Detected in all" 4 "white matter: 1789.4" "Low region specificity" "Detected in all" "CAB002672, HPA023266, HPA023278, HPA023280, HPA023338" Enhanced Supported Supported "Plasma membrane" NA NA 46000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 17: WM-115 - Nervous system development" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Plasma membrane" "CAB002672: , HPA023266: AB_1847058, HPA023278: AB_1847060, HPA023280: AB_1847061, HPA023338: AB_1847062" "unprognostic (2.17e-1)" "unprognostic (4.48e-2)" "unprognostic (3.85e-3)" "unprognostic (1.41e-1)" "unprognostic (3.09e-1)" "unprognostic (9.71e-2)" "unprognostic (2.58e-3)" "unprognostic (2.08e-1)" "unprognostic (2.23e-1)" "unprognostic (1.62e-1)" "unprognostic (5.76e-3)" "unprognostic (1.87e-1)" "unprognostic (2.99e-3)" "unprognostic (1.60e-1)" "unprognostic (1.55e-1)" "unprognostic (8.86e-2)" "unprognostic (1.10e-3)" 34.4 33.5 493.1 31.2 889.6 23.4 29.6 715.5 681.5 41.7 193.5 56.9 21.4 33.5 36.7 63.4 28.9 32.6 25.3 505.1 577.0 58.1 44.8 21.7 35.7 839.4 761.8 32.2 27.8 23.7 28.1 23.5 793.8 41.5 18.4 20.5 47.2 37.2 26.3 34.3 31.4 30.3 644.6 25.8 29.8 16.7 791.1 31.2 24.7 22.2 35.1 37.3 40.5 1395.7 56.9 92.4 85.8 106.6 71.7 67.2 38.5 70.1 102.5 171.1 191.5 73.0 49.6 59.0 54.3 88.5 88.1 95.0 58.3 44.6 59.0 59.7 76.8 56.7 59.3 127.7 76.9 56.7 49.6 111.0 31.5 94.1 22.8 61.9 79.4 58.0 42.4 46.4 60.6 35.1 148.5 50.9 20.7 29.8 66.5 91.4 126.7 58.7 45.7 55.7 50.9 69.5 85.7 127.0 155.5 41.6 57.2 82.3 80.2 66.6 73.7 92.3 81.9 53.4 66.6 47.5 66.1 42.9 266.4 18.7 38.2 23.4 21.5 40.7 17.2 28.0 18.8 17.4 33.8 19.2 16.6 19.6 7.7 23.5 34.0 149.4 22.4 33.0 493.1 889.6 715.5 681.5 505.1 577.0 839.4 761.8 793.8 644.6 791.1 1395.7 26.6 16.0 12.7 14.4 19.0 16.7 17.5 10.4 16.5 22.0 29.5 24.0 13.0 20.0 19.5 35.0 6.2 30.6 53.2 39.9 125.2 46.3 1.3 19.1 27.1 24.8 19.7 25.2 6.8 41.7 50.2 27.7 17.9 21.3 9.5 20.2 20.3 32.3 39.8 50.5 9.5 16.2 18.3 17.0 14.5 4.0 38.8 20.3 55.2 14.0 25.0 84.7 23.7 45.2 555.6 35.5 19.0 36.1 27.8 21.7 19.0 80.5 12.8 25.4 32.9 36.6 29.4 5.1 16.0 30.9 18.9 13.0 16.9 33.3 20.6 17.4 COMT ENSG00000093010 Catechol-O-methyltransferase P21964 22 19941371-19969975 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Catecholamine metabolism, Neurotransmitter degradation" "Methyltransferase, Transferase" "FDA approved drug targets, Schizophrenia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 885.9;Syncytiotrophoblasts: 648.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MCF7: 818.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001169, CAB011233" Enhanced Enhanced "Endoplasmic reticulum,Vesicles" NA NA 43000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 15: Liver - Metabolism" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 47: Cytotrophoblasts - Unknown function" Vesicles "Endoplasmic reticulum" "CAB011233: , HPA001169: AB_1078402" "unprognostic (5.20e-2)" "unprognostic (2.73e-2)" "unprognostic (3.08e-2)" "prognostic favorable (3.68e-4)" "unprognostic (2.99e-2)" "unprognostic (2.32e-3)" "unprognostic (5.54e-3)" "unprognostic (9.14e-2)" "unprognostic (1.39e-1)" "unprognostic (1.40e-1)" "unprognostic (2.14e-3)" "prognostic favorable (5.67e-4)" "prognostic unfavorable (9.76e-4)" "unprognostic (2.27e-1)" "unprognostic (7.09e-2)" "unprognostic (3.97e-1)" "unprognostic (1.07e-2)" 78.1 180.7 99.3 39.6 108.9 71.8 85.5 114.4 140.4 105.3 119.6 80.1 55.0 76.9 47.7 198.0 65.2 60.3 81.7 96.6 107.4 94.2 292.3 93.3 49.7 117.4 107.9 107.4 74.0 61.5 48.7 116.9 117.3 87.2 20.7 17.2 133.7 70.5 98.6 119.7 64.1 38.3 109.2 63.6 99.8 51.7 102.7 26.9 59.1 49.9 26.0 86.9 124.1 124.3 131.3 131.7 15.0 128.3 141.2 122.5 6.0 143.9 178.8 120.3 133.6 112.1 148.6 51.7 62.7 208.9 48.6 172.9 23.6 152.0 26.2 115.1 163.4 92.5 65.1 267.1 265.1 155.0 35.3 159.2 180.7 104.3 101.3 116.6 113.2 82.0 383.2 109.4 100.6 818.5 63.4 267.9 32.4 361.1 42.9 88.2 127.9 72.8 129.0 404.5 60.4 53.8 47.7 405.7 125.7 7.6 84.0 436.6 137.5 212.7 82.2 71.0 109.6 37.5 18.0 41.2 236.0 211.3 152.5 62.2 312.2 59.6 77.9 218.1 64.0 56.8 52.6 62.6 251.5 57.8 45.5 51.7 12.0 73.5 151.5 291.4 72.6 178.6 99.3 108.9 114.4 140.4 96.6 107.4 117.4 107.9 117.3 109.2 102.7 124.3 99.1 125.0 88.1 22.9 33.1 102.1 231.9 248.1 188.4 73.4 174.9 218.4 41.9 104.4 162.7 152.6 10.4 885.9 80.1 53.0 320.8 201.0 4.6 59.1 72.2 86.7 84.5 70.0 16.8 193.0 113.5 103.1 46.4 46.9 71.7 95.7 77.1 262.0 311.4 25.2 17.2 97.7 191.2 177.0 107.7 13.3 134.2 137.0 240.1 20.6 137.0 158.7 41.2 25.1 45.7 170.2 108.8 179.8 45.5 132.4 179.9 73.8 135.8 43.2 138.1 143.3 113.1 8.4 5.7 236.4 123.5 648.5 41.8 222.0 122.3 206.6 COP1 "CFAP78, FAP78, FLJ10416, RFWD2, RNF200" ENSG00000143207 "COP1 E3 ubiquitin ligase" Q8NHY2 1 175944831-176207286 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 28.1;Extravillous trophoblasts: 33.5;Syncytiotrophoblasts: 31.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 15: RT4 - Unknown function" "Cluster 7: Non-specific - Mitochondria" "unprognostic (1.99e-1)" "unprognostic (3.76e-2)" "unprognostic (4.17e-2)" "prognostic unfavorable (3.96e-4)" "unprognostic (2.95e-2)" "unprognostic (4.33e-1)" "unprognostic (2.01e-2)" "unprognostic (1.10e-1)" "unprognostic (2.78e-2)" "unprognostic (3.52e-2)" "unprognostic (9.24e-2)" "unprognostic (1.67e-1)" "unprognostic (1.33e-2)" "unprognostic (6.68e-2)" "unprognostic (7.01e-2)" "unprognostic (1.59e-1)" "unprognostic (1.55e-1)" 14.2 9.5 5.9 12.0 7.1 16.8 12.7 11.4 9.1 12.1 8.4 18.1 13.8 11.8 9.8 14.2 9.4 9.5 9.8 8.5 5.9 12.4 16.6 12.5 15.7 4.6 5.0 8.7 13.2 10.5 8.0 11.2 5.0 10.1 16.7 8.6 13.1 8.5 13.6 17.5 13.9 11.0 5.7 16.7 13.7 15.6 6.1 14.9 10.6 7.4 16.8 14.7 11.9 8.8 35.3 17.5 22.1 13.8 23.0 22.6 56.1 21.7 22.0 17.7 18.6 30.0 28.1 59.4 25.8 20.9 18.9 32.3 16.9 27.0 17.7 23.7 17.0 22.6 19.4 28.0 18.9 49.2 33.0 16.8 28.9 17.6 19.8 17.9 26.6 21.7 43.9 24.9 24.8 42.5 27.0 28.2 47.4 55.8 2.0 26.1 20.4 40.2 26.8 93.7 22.6 41.6 27.8 44.9 35.9 37.4 32.1 69.1 40.4 19.4 16.1 28.3 23.4 35.3 62.7 49.8 19.1 26.7 26.9 8.5 3.0 12.0 1.9 3.7 1.4 1.7 2.0 1.4 2.1 1.5 2.7 2.0 14.1 0.6 3.4 1.1 1.7 1.0 5.9 7.1 11.4 9.1 8.5 5.9 4.6 5.0 5.0 5.7 6.1 8.8 15.8 22.4 14.5 0.0 4.4 0.0 0.0 0.0 0.0 0.0 15.4 10.9 0.0 0.0 3.1 9.2 0.0 28.1 12.2 0.0 21.5 14.8 0.0 17.9 14.6 7.2 0.0 0.0 0.0 22.7 33.5 7.4 0.0 20.1 7.6 18.1 0.0 0.0 22.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.0 0.0 0.0 10.3 0.0 0.0 0.0 0.0 21.8 0.0 0.0 3.1 0.0 0.0 22.1 4.4 0.0 0.0 0.0 7.7 0.0 0.0 0.0 0.0 31.3 6.7 13.8 0.0 0.0 CPA1 CPA ENSG00000091704 "Carboxypeptidase A1" P15085 7 130380339-130388114 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 2326 "pancreas: 237498.3" "Cell type enriched" "Detected in some" 19 "Exocrine glandular cells: 10133.0" "Cancer enriched" "Detected in some" 639 "pancreatic cancer: 1377.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "AN3-CA: 11.8" "Not detected" "Not detected" "Low region specificity" "Detected in some" "HPA021836, CAB025197, HPA052215" Enhanced "Secreted to digestive system" NA NA 110000000 "Cluster 25: Pancreas - Digestion" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 1: Pancreatic cells - Digestion" "CAB025197: , HPA021836: AB_1846005, HPA052215: AB_2681764" "unprognostic (8.41e-2)" "unprognostic (9.24e-4)" "unprognostic (5.22e-2)" "unprognostic (1.76e-1)" "unprognostic (3.97e-1)" "unprognostic (1.76e-1)" "unprognostic (2.27e-1)" "unprognostic (1.15e-2)" "unprognostic (1.35e-1)" "unprognostic (1.34e-6)" "unprognostic (4.99e-1)" "unprognostic (1.67e-1)" "unprognostic (2.16e-1)" "unprognostic (4.37e-2)" 27.9 4.8 0.2 5.6 0.2 4.7 13.6 0.1 0.2 11.9 1.2 4.5 33.6 5.0 0.1 6.9 3.7 0.2 43.5 0.2 0.3 4.6 12.9 3.3 8.7 0.1 0.1 102.1 237498.3 0.0 5.0 18.4 0.1 6.9 0.0 0.2 39.5 0.1 4.7 6.6 20.8 0.4 0.2 7.7 21.3 5.4 0.2 0.1 3.0 0.4 0.0 2.8 4.0 0.4 0.0 0.0 0.0 11.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.4 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 2.1 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 1.7 0.0 0.2 0.0 1.5 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.1 0.2 0.2 0.3 0.1 0.1 0.1 0.2 0.2 0.4 0.1 3.2 0.0 0.3 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.9 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.0 5.9 12.0 1.9 0.0 0.1 0.1 0.0 0.0 0.0 10133.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 7.6 0.9 1.2 0.0 1.0 44.5 2.1 0.0 0.0 0.0 527.2 0.0 0.7 0.0 0.4 0.0 0.0 0.0 0.1 0.0 16.2 2.7 0.9 5.5 0.0 0.0 1.6 0.0 2.5 0.0 0.1 CPA2 ENSG00000158516 "Carboxypeptidase A2" P48052 7 130266863-130289798 "Enzymes, Metabolic proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 416 "pancreas: 45360.2" "Cell type enriched" "Detected in some" 10 "Exocrine glandular cells: 4973.8" "Cancer enriched" "Detected in many" 60 "pancreatic cancer: 411.4" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AN3-CA: 2.2;CACO-2: 3.8;RH-30: 3.0;SCLC-21H: 1.6" "Low region specificity" "Detected in all" "Not detected" "Not detected" "HPA020342, HPA021317" Enhanced Approved "Golgi apparatus" "Secreted to digestive system" NA NA 1500000 "Cluster 25: Pancreas - Digestion" "Cluster 39: CACO-2 - Unknown function" "Cluster 1: Pancreatic cells - Digestion" "Golgi apparatus" "HPA020342: AB_1846007, HPA021317: AB_1846008" "unprognostic (1.12e-1)" "unprognostic (3.97e-1)" "unprognostic (4.21e-2)" "unprognostic (1.82e-2)" "unprognostic (1.38e-1)" "unprognostic (6.76e-2)" "unprognostic (4.65e-2)" "unprognostic (1.08e-1)" "unprognostic (1.40e-1)" "unprognostic (1.84e-1)" "unprognostic (2.66e-1)" "unprognostic (3.84e-5)" "unprognostic (7.52e-2)" "unprognostic (1.42e-1)" "unprognostic (7.12e-2)" "unprognostic (8.48e-2)" 5.5 1.0 0.3 0.7 0.8 0.4 2.6 1.0 0.9 1.9 0.2 1.3 17.4 0.8 0.1 1.5 0.7 0.0 8.4 0.3 0.6 0.9 2.6 0.7 1.4 2.8 1.3 19.7 45360.2 0.0 1.4 3.2 2.5 1.5 0.4 0.8 7.8 0.0 0.8 1.1 30.6 0.0 1.2 1.2 108.9 2.2 1.1 0.1 0.6 0.0 0.0 0.5 0.8 3.1 0.0 0.0 0.4 2.2 0.0 0.0 0.0 0.0 0.0 0.3 0.0 3.8 0.0 0.0 0.5 0.0 0.3 0.0 0.7 0.0 0.0 0.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.2 0.0 3.0 0.0 0.0 0.3 1.6 0.0 0.1 0.0 1.0 0.1 0.0 0.1 0.0 0.0 0.6 0.4 0.3 0.0 0.4 0.1 0.4 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.8 1.0 0.9 0.3 0.6 2.8 1.3 2.5 1.2 1.1 3.1 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.3 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.6 1.9 8.1 4.3 0.0 0.0 0.9 0.0 0.0 0.1 4973.8 0.0 0.2 4.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.5 0.0 0.0 0.0 10.5 0.3 0.5 0.0 0.0 13.9 4.6 0.0 0.5 1.0 471.3 52.9 0.0 0.0 0.0 9.9 0.0 0.0 0.3 0.0 0.0 1.3 0.4 2.0 0.0 0.1 0.3 0.0 0.2 1.5 0.2 CPA3 ENSG00000163751 "Carboxypeptidase A3" P15088 3 148865296-148897203 "Enzymes, Metabolic proteins, Plasma proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 112.0;lung: 86.3" "Cell type enriched" "Detected in some" 26 "granulocytes: 4422.8" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 1534 "basophil: 1115.4" "Lineage enriched" "Detected in single" 5518 "granulocytes: 1115.4" "Cell line enriched" "Detected in some" 45 "HEL: 303.3" "Not detected" "Not detected" "HPA006479, HPA008689, CAB020712" Enhanced Approved "Nucleoplasm,Golgi apparatus" "Secreted to blood" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 36: HEL - Hemostasis" "Cluster 60: Granulocytes - Receptor signaling" "Golgi apparatus" Nucleoplasm "CAB020712: , HPA006479: AB_1078396, HPA008689: AB_1846009" "unprognostic (1.07e-1)" "unprognostic (3.03e-2)" "unprognostic (2.66e-3)" "unprognostic (9.13e-3)" "unprognostic (3.50e-1)" "unprognostic (1.18e-3)" "unprognostic (2.47e-1)" "unprognostic (1.57e-2)" "unprognostic (2.14e-1)" "unprognostic (9.51e-2)" "unprognostic (1.89e-1)" "unprognostic (5.30e-3)" "unprognostic (3.50e-3)" "unprognostic (5.18e-3)" "unprognostic (3.24e-2)" "unprognostic (1.74e-1)" "unprognostic (1.69e-3)" 18.2 2.6 0.0 19.9 0.4 25.7 20.9 0.0 0.0 59.4 0.3 39.2 27.3 26.1 19.3 41.1 6.6 112.0 6.2 0.0 0.0 3.3 2.7 86.3 11.2 0.0 0.0 0.9 21.0 2.8 0.9 1.7 0.0 18.5 56.6 0.0 12.1 15.1 1.6 17.7 45.9 25.7 0.0 1.1 45.3 3.8 0.0 14.9 0.9 10.2 15.1 54.0 10.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 2.6 4.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.7 0.0 0.0 303.3 0.0 0.0 0.2 0.2 6.7 0.2 0.0 0.1 0.3 0.5 3.8 0.0 0.1 0.0 1.8 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1115.4 0.0 0.7 0.0 0.1 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.1 0.4 0.0 0.2 0.0 0.0 2.9 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 32.1 163.9 0.0 0.5 1.7 0.4 0.0 0.0 0.0 0.0 0.0 0.3 0.0 17.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 3.7 0.0 16.0 0.0 1.6 0.0 3.5 0.5 0.0 4422.8 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 5.0 1.8 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 6.7 0.3 0.0 0.0 8.7 0.0 0.0 0.2 0.3 0.0 0.0 0.0 1.3 0.0 41.7 0.0 0.0 0.3 CPA5 ENSG00000158525 "Carboxypeptidase A5" Q8WXQ8 7 130344816-130368730 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 15 "testis: 33.6" "Group enriched" "Detected in some" 23 "Early spermatids: 76.1;Late spermatids: 144.1" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Group enriched" "Detected in some" 4 "memory CD4 T-cell: 16.8;naive CD8 T-cell: 42.5;T-reg: 56.4" "Lineage enriched" "Detected in single" 102 "T-cells: 56.4" "Cell line enhanced" "Detected in some" "RH-30: 7.3;RT4: 3.4;U-266/84: 6.0" "Not detected" "Not detected" HPA020322 Approved Nucleoplasm "Secreted in male reproductive system" NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 83: Testis - Spermatogenesis" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "HPA020322: AB_10960562" "unprognostic (2.44e-1)" "unprognostic (3.76e-1)" "unprognostic (1.50e-1)" "unprognostic (5.94e-2)" "unprognostic (4.96e-2)" "unprognostic (7.10e-3)" "unprognostic (1.64e-2)" "unprognostic (1.41e-2)" "unprognostic (3.26e-1)" "unprognostic (5.02e-2)" "unprognostic (5.83e-4)" "unprognostic (1.43e-1)" "unprognostic (8.88e-13)" "unprognostic (5.16e-2)" "unprognostic (1.32e-1)" "unprognostic (8.81e-2)" "unprognostic (3.08e-2)" 0.3 0.2 0.3 0.1 0.2 0.2 0.1 0.2 1.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.5 0.2 0.0 0.0 1.9 0.3 0.4 0.0 0.5 0.0 1.2 0.6 0.4 0.1 0.0 0.0 0.0 0.0 0.2 1.0 0.7 0.0 0.2 1.8 0.0 33.6 0.5 2.2 0.3 0.0 0.9 0.6 0.0 0.4 0.5 0.0 0.0 0.4 0.0 0.0 0.0 0.3 2.1 0.1 0.2 1.6 0.0 0.0 0.0 0.0 0.7 0.0 0.2 0.4 0.0 0.0 1.2 0.5 0.5 0.8 0.3 0.0 0.0 0.0 0.7 0.0 0.9 0.9 0.0 0.6 0.0 1.0 0.0 0.0 0.3 0.0 0.4 0.0 0.0 0.0 7.3 0.2 1.0 3.4 0.9 0.1 0.0 2.0 0.0 0.1 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 6.0 0.0 0.3 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.6 0.0 16.8 8.6 0.0 0.0 4.2 42.5 0.0 0.0 0.0 0.0 56.4 5.8 0.3 0.2 0.2 1.0 0.4 0.5 0.3 0.4 0.4 0.2 0.5 0.4 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.8 0.6 0.3 0.0 0.0 1.8 0.0 3.1 0.0 0.0 0.0 0.1 76.1 0.2 0.0 0.1 0.0 0.0 0.1 0.2 0.2 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 144.1 0.9 0.1 0.0 0.0 0.9 0.0 2.1 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.1 0.0 0.0 0.0 2.1 0.0 3.8 2.6 0.0 0.0 4.7 4.0 0.0 0.0 0.1 CPA6 CPAH ENSG00000165078 "Carboxypeptidase A6" Q8N4T0 8 67422038-67746378 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 2.3;prostate: 2.7;retina: 2.2" "Cell type enhanced" "Detected in some" "Basal prostatic cells: 31.7;Early spermatids: 21.7;Microglial cells: 12.2;Muller glia cells: 22.5;Pancreatic endocrine cells: 21.5;Paneth cells: 12.8;Prostatic glandular cells: 11.3;Urothelial cells: 36.6" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CACO-2: 2.5;EFO-21: 1.5;Hep G2: 3.4;OE19: 1.5" "Region enriched" "Detected in some" 9 "olfactory bulb: 12.6" "Low region specificity" "Detected in all" "Secreted to extracellular matrix" NA NA "Cluster 37: Intestine - Unknown function" "Cluster 39: CACO-2 - Unknown function" "Cluster 22: Epithelial cell types - Mixed function" "unprognostic (2.85e-2)" "unprognostic (1.95e-1)" "unprognostic (1.72e-2)" "unprognostic (1.14e-1)" "unprognostic (2.58e-1)" "unprognostic (2.24e-1)" "unprognostic (2.08e-1)" "unprognostic (2.88e-1)" "unprognostic (9.35e-2)" "unprognostic (1.65e-1)" "unprognostic (5.23e-2)" "unprognostic (6.99e-2)" "unprognostic (3.57e-4)" "unprognostic (9.61e-5)" "unprognostic (1.75e-1)" "unprognostic (9.09e-2)" "unprognostic (1.41e-2)" 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.6 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 2.3 2.2 0.0 0.2 0.0 0.0 0.2 0.8 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.0 1.2 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 1.5 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.0 31.7 0.0 5.7 0.2 0.1 0.4 0.2 0.0 0.1 0.0 0.0 0.0 0.0 2.3 0.0 0.0 21.7 0.1 0.0 0.1 2.4 0.0 1.6 0.4 0.0 0.4 0.0 0.7 0.0 0.0 0.0 0.0 0.1 1.7 1.3 2.2 0.0 0.0 0.0 3.2 1.8 0.2 0.0 12.2 0.1 22.5 0.0 3.0 1.3 21.5 12.8 0.0 0.0 11.3 0.0 0.0 0.0 1.0 0.0 0.1 0.3 0.0 0.0 0.8 0.0 0.0 0.6 0.0 5.7 36.6 CREBBP "CBP, KAT3A, RSTS, RTS" ENSG00000005339 "CREB binding protein" Q92793 16 3725054-3880713 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, Host-virus interaction, Transcription, Transcription regulation" "Activator, Acyltransferase, Transferase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004212, HPA055861" Supported Supported "Nucleoplasm,Nuclear bodies" No No "Cluster 1: Neutrophils - Mixed function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Nucleoplasm "Nuclear bodies" "CAB004212: AB_626817, HPA055861: AB_2682948" "unprognostic (1.17e-1)" "unprognostic (8.51e-2)" "unprognostic (1.60e-1)" "unprognostic (1.63e-1)" "unprognostic (1.49e-1)" "unprognostic (5.09e-2)" "unprognostic (9.59e-3)" "unprognostic (6.98e-2)" "unprognostic (8.96e-2)" "unprognostic (1.08e-1)" "unprognostic (1.76e-1)" "unprognostic (2.84e-1)" "prognostic favorable (6.24e-5)" "unprognostic (1.47e-1)" "unprognostic (1.74e-1)" "unprognostic (3.97e-2)" "unprognostic (8.23e-2)" 17.4 10.6 5.8 17.1 5.2 52.9 16.8 25.4 11.5 20.9 3.7 18.8 12.5 26.5 12.4 16.5 22.4 16.6 14.4 5.9 3.1 12.0 14.3 15.9 17.6 8.9 6.8 37.3 29.7 18.5 11.3 16.9 2.9 16.1 14.1 13.8 17.2 16.2 29.6 21.0 16.4 19.6 0.4 21.0 16.3 33.2 7.9 29.1 23.3 28.9 20.7 16.6 16.5 6.4 12.3 31.0 39.3 17.4 23.5 23.1 20.4 17.4 28.9 29.2 28.2 28.2 22.4 33.7 20.1 33.3 18.7 23.2 45.7 14.2 32.9 57.5 18.5 26.6 29.2 17.9 26.0 26.9 36.5 20.7 14.2 32.5 38.9 18.0 22.3 17.0 30.9 44.8 16.0 42.0 17.9 13.0 32.3 11.7 12.7 83.4 31.1 26.1 11.2 16.2 32.6 21.5 29.5 28.7 16.8 25.3 25.6 25.9 34.7 35.5 35.2 18.4 16.0 20.8 24.3 63.7 7.2 15.8 25.6 1.9 1.1 0.9 1.7 1.5 0.8 3.7 0.8 1.3 0.7 2.1 0.8 1.1 6.7 1.4 2.9 1.5 0.8 0.9 5.8 5.2 25.4 11.5 5.9 3.1 8.9 6.8 2.9 0.4 7.9 6.4 48.1 44.8 51.6 91.1 38.3 56.2 31.0 16.0 27.3 34.2 34.4 25.7 41.2 40.0 28.0 11.0 25.0 17.4 50.1 31.2 5.9 20.9 43.0 37.2 56.4 35.7 15.0 33.4 88.7 20.3 11.3 39.5 32.1 63.5 30.4 53.1 32.5 29.5 20.9 28.6 89.8 25.3 18.3 44.0 42.8 80.2 56.5 49.0 17.8 87.1 52.5 34.5 43.3 111.6 101.2 27.5 19.5 51.1 35.6 39.8 25.2 10.9 28.2 17.6 46.0 75.8 44.9 35.1 42.2 34.6 58.8 30.8 44.2 36.2 24.6 44.2 CSNK1A1 "CK1, CK1a, CK1alpha, CKIa, CKIalpha" ENSG00000113712 "Casein kinase 1 alpha 1" P48729 5 149492982-149551471 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Suprabasal keratinocytes: 847.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB016680, HPA051334" Uncertain Approved Cytosol NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 30: Epithelial cell lines - Translation" "Cluster 22: Epithelial cell types - Mixed function" Cytosol "CAB016680: AB_1614518, HPA051334: AB_2681446" "unprognostic (4.27e-3)" "unprognostic (5.85e-3)" "prognostic favorable (1.15e-4)" "unprognostic (7.39e-2)" "unprognostic (2.66e-1)" "unprognostic (3.14e-1)" "unprognostic (1.27e-2)" "unprognostic (5.56e-2)" "unprognostic (4.38e-1)" "unprognostic (8.31e-2)" "prognostic unfavorable (5.79e-4)" "unprognostic (5.47e-2)" "unprognostic (1.56e-1)" "unprognostic (7.92e-2)" "unprognostic (4.41e-2)" "unprognostic (6.28e-3)" "unprognostic (6.92e-2)" 77.0 67.6 49.0 67.3 53.9 210.8 97.8 60.0 52.7 67.9 61.5 83.2 56.6 73.7 60.2 142.4 56.6 79.7 87.6 48.6 55.9 50.3 68.2 69.6 60.0 61.3 56.4 53.2 55.0 99.4 48.8 71.7 56.6 88.3 68.2 57.6 71.3 69.2 104.1 121.4 63.1 82.9 57.9 60.7 73.5 45.6 57.8 81.0 76.9 59.5 81.8 94.8 82.3 66.3 154.4 106.4 151.0 144.1 143.6 191.4 185.0 189.7 176.8 146.0 153.5 194.1 187.0 71.6 221.3 183.3 140.7 153.9 101.2 292.5 184.1 124.6 78.0 96.9 96.6 87.8 143.1 163.9 148.4 158.5 313.4 148.1 269.0 163.9 184.7 137.2 102.2 116.0 140.7 104.4 152.2 66.6 71.4 167.6 247.3 129.0 96.1 98.9 112.3 248.3 123.5 110.5 151.1 193.3 200.8 135.6 194.1 134.4 164.6 168.6 83.6 118.2 197.1 117.0 149.2 100.6 169.2 95.6 216.9 106.0 72.6 66.6 47.5 68.9 51.6 50.2 58.1 49.7 80.0 39.9 61.4 55.2 61.1 63.7 67.8 47.4 76.7 94.7 49.0 53.9 60.0 52.7 48.6 55.9 61.3 56.4 56.6 57.9 57.8 66.3 169.7 147.4 176.7 137.1 101.8 684.5 583.1 270.0 187.8 135.8 257.0 158.4 63.5 90.1 298.1 115.8 64.6 171.2 135.6 126.8 92.0 167.1 95.7 195.8 193.5 191.1 129.9 146.7 108.4 184.1 223.7 159.8 124.4 285.2 117.6 114.0 216.4 108.9 136.1 151.4 115.4 141.9 154.6 167.8 311.5 87.5 104.1 183.8 152.9 119.0 156.6 156.9 108.1 168.4 198.1 197.2 113.9 111.7 105.4 368.6 120.4 102.8 276.7 109.6 157.8 190.2 216.1 181.9 88.9 272.4 847.7 350.9 133.5 177.0 115.7 485.2 CSNK1A1L MGC33182 ENSG00000180138 "Casein kinase 1 alpha 1 like" Q8N752 13 37103259-37105664 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in single" 6 "testis: 3.5" "Group enriched" "Detected in some" 6 "Early spermatids: 30.0;Late spermatids: 23.0;Spermatocytes: 16.1" "Not detected" "Not detected" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 33 "neutrophil: 7.6" "Lineage enriched" "Detected in single" 39 "granulocytes: 7.6" "Not detected" "Not detected" HPA051334 Uncertain Cytosol NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 78: Testis - Spermatogenesis" "Cluster 10: Non-specific - Unknown function" Cytosol "HPA051334: AB_2681446" "unprognostic (1.23e-2)" "unprognostic (1.59e-1)" "unprognostic (3.19e-2)" "unprognostic (3.54e-2)" "unprognostic (2.40e-2)" "unprognostic (5.40e-2)" "unprognostic (8.90e-2)" "unprognostic (3.47e-1)" "unprognostic (1.47e-3)" "unprognostic (4.50e-1)" "unprognostic (2.02e-1)" "unprognostic (2.28e-3)" "unprognostic (3.45e-1)" "unprognostic (2.38e-1)" 0.0 0.0 0.0 0.1 0.1 0.5 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 3.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 7.6 0.1 0.1 0.0 0.1 0.2 0.0 0.1 0.0 0.2 0.0 0.1 0.1 0.0 0.1 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.1 1.8 3.5 0.2 0.0 0.0 0.0 0.0 2.4 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.1 30.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.1 0.3 0.0 0.0 0.0 0.0 1.4 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.7 23.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.1 0.0 0.0 0.6 2.2 16.1 1.2 0.0 2.7 0.3 0.0 0.0 0.1 1.7 CSNK1D "CKID, CKIdelta, HCKID" ENSG00000141551 "Casein kinase 1 delta" P48730 17 82239023-82273731 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Early spermatids: 312.5;Late spermatids: 775.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB015410 Approved Approved "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 72: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoli fibrillar center" Nucleoplasm "CAB015410: AB_831049" "unprognostic (1.07e-2)" "unprognostic (1.27e-1)" "unprognostic (2.31e-1)" "prognostic unfavorable (7.04e-4)" "unprognostic (2.38e-2)" "unprognostic (3.43e-2)" "prognostic unfavorable (2.38e-6)" "unprognostic (8.05e-2)" "unprognostic (1.09e-1)" "unprognostic (5.00e-2)" "prognostic favorable (9.62e-5)" "unprognostic (2.23e-3)" "prognostic unfavorable (8.34e-4)" "unprognostic (3.54e-1)" "unprognostic (2.52e-1)" "unprognostic (5.52e-3)" "unprognostic (4.74e-2)" 46.7 57.0 36.9 28.9 36.9 25.9 42.3 34.4 37.9 45.3 30.3 57.1 35.1 56.6 26.7 50.8 45.3 24.8 42.4 39.0 40.2 45.5 40.9 45.3 30.8 37.2 37.6 43.1 47.5 43.1 54.2 30.2 36.3 51.8 20.0 15.1 48.6 36.8 88.9 36.4 50.9 29.0 36.3 56.3 49.3 60.7 42.6 34.0 44.7 38.7 22.8 49.0 37.0 32.9 60.3 70.9 39.5 54.7 50.8 53.9 77.7 85.1 54.4 61.0 56.8 58.6 49.4 55.0 66.3 62.5 64.8 57.1 37.4 88.3 48.9 47.0 90.5 68.5 53.4 63.7 146.9 56.9 50.4 81.9 61.5 41.6 61.3 76.0 90.0 39.5 78.5 28.4 58.5 70.6 73.7 59.3 42.2 71.3 108.6 62.6 48.7 49.7 64.8 93.4 48.5 87.4 100.4 85.5 97.7 54.3 61.5 73.0 95.6 86.9 77.3 76.2 67.0 61.0 32.1 58.4 69.5 48.1 64.7 8.8 20.8 27.4 12.3 21.3 11.8 11.1 9.6 12.1 20.1 9.0 8.1 8.7 50.4 15.3 20.3 9.6 9.2 15.4 36.9 36.9 34.4 37.9 39.0 40.2 37.2 37.6 36.3 36.3 42.6 32.9 65.8 48.1 54.3 36.6 81.1 56.6 116.0 58.3 52.9 46.5 59.8 51.2 19.7 31.5 65.7 42.3 27.1 61.8 101.0 105.2 33.2 71.6 312.5 69.6 54.0 54.2 46.2 32.4 24.4 69.6 95.2 42.8 87.1 93.2 60.1 45.3 42.5 33.6 65.3 95.9 21.2 62.8 67.1 51.5 83.8 775.6 30.1 75.7 28.4 24.4 65.8 28.7 79.3 24.6 21.2 87.7 83.2 40.3 80.9 90.8 94.3 43.8 66.6 54.4 39.5 78.6 57.5 55.1 29.6 44.2 48.3 126.6 87.6 46.7 56.7 118.6 CSNK1E "CKIE, CKIepsilon, HCKIE" ENSG00000213923 "Casein kinase 1 epsilon" P49674 22 38290691-38318084 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Biological rhythms" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Urothelial cells: 280.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "plasmacytoid DC: 15.9" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "CAB009626, HPA026288" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 57: Non-specific - Angiogenesis" "Cluster 17: WM-115 - Nervous system development" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Cytosol" "CAB009626: AB_2084517, HPA026288: AB_1847276" "unprognostic (2.32e-1)" "unprognostic (8.41e-2)" "unprognostic (5.14e-2)" "unprognostic (5.01e-3)" "unprognostic (1.95e-2)" "unprognostic (4.50e-3)" "prognostic unfavorable (8.20e-5)" "unprognostic (2.08e-3)" "unprognostic (3.69e-1)" "unprognostic (1.22e-1)" "unprognostic (9.63e-2)" "unprognostic (4.16e-3)" "prognostic unfavorable (4.67e-6)" "unprognostic (1.91e-1)" "unprognostic (1.66e-1)" "unprognostic (2.58e-1)" "unprognostic (3.25e-3)" 87.1 52.8 81.1 41.2 82.6 51.6 88.3 80.8 95.1 93.6 66.0 73.0 41.4 82.7 52.5 69.0 83.3 48.7 80.9 82.9 73.7 70.2 37.4 92.2 40.3 78.9 78.6 109.5 64.9 74.1 85.1 71.2 79.5 80.3 35.5 47.3 71.6 44.9 60.5 94.8 50.9 45.3 70.2 63.6 58.0 29.5 83.2 33.3 64.4 47.2 37.8 65.7 88.4 93.9 101.5 57.4 121.6 114.7 61.5 88.3 92.1 126.9 168.6 116.7 114.3 63.9 76.7 74.2 53.0 120.7 70.7 77.9 96.1 177.9 79.2 123.0 215.2 23.9 181.2 47.4 123.7 48.3 61.9 90.2 143.8 171.7 220.3 141.0 121.1 60.6 50.9 155.0 110.8 68.4 71.1 60.9 87.2 67.3 69.1 130.8 90.1 123.4 99.0 92.4 181.6 69.3 102.9 109.3 124.7 68.0 59.5 73.0 134.3 94.0 111.3 58.7 102.1 61.2 105.2 104.5 151.0 56.9 176.3 4.8 1.6 3.6 3.0 0.8 3.8 2.1 3.4 3.0 1.8 3.1 1.9 2.5 3.8 5.7 0.5 15.9 1.6 1.2 81.1 82.6 80.8 95.1 82.9 73.7 78.9 78.6 79.5 70.2 83.2 93.9 73.4 38.5 21.7 0.0 32.3 78.6 158.8 89.1 68.9 132.6 53.7 42.4 49.8 34.3 73.9 23.9 60.5 35.2 42.3 28.4 7.9 30.8 46.0 94.3 72.5 76.4 62.8 12.6 0.0 41.8 49.2 60.8 39.8 126.5 3.8 46.6 45.0 21.3 23.1 72.3 0.0 46.0 46.8 17.6 54.1 69.1 85.4 21.8 60.5 0.0 13.3 117.9 28.8 0.0 0.0 57.5 33.1 66.2 83.5 160.5 9.0 6.5 62.8 60.7 72.3 85.7 98.0 8.0 20.0 50.3 104.7 125.5 26.0 34.9 37.6 280.8 CSNK1G1 CK1gamma1 ENSG00000169118 "Casein kinase 1 gamma 1" Q9HCP0 15 64165525-64356173 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 35.0" "Cell type enhanced" "Detected in all" "Early spermatids: 130.6;Late spermatids: 261.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA018209 Supported Cytosol NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" Cytosol "HPA018209: AB_1847278" "unprognostic (9.10e-2)" "unprognostic (8.09e-2)" "unprognostic (1.20e-1)" "unprognostic (2.65e-2)" "unprognostic (1.20e-1)" "unprognostic (1.64e-1)" "unprognostic (7.90e-3)" "unprognostic (3.07e-1)" "unprognostic (1.61e-2)" "unprognostic (2.02e-1)" "unprognostic (8.63e-2)" "unprognostic (3.75e-2)" "unprognostic (7.51e-2)" "unprognostic (8.16e-3)" "unprognostic (1.31e-1)" "unprognostic (2.59e-2)" "unprognostic (2.41e-1)" 4.0 3.4 6.1 6.1 6.9 9.0 6.0 6.4 7.7 5.4 6.3 5.0 3.9 4.5 6.7 7.9 7.3 4.0 2.9 10.4 7.1 5.3 2.9 5.3 5.9 2.8 4.3 5.2 4.1 6.3 4.7 4.9 2.6 3.7 5.4 14.5 3.6 4.4 4.1 6.6 3.8 5.3 3.6 5.9 4.3 35.0 6.8 9.3 7.9 3.3 6.8 5.5 4.6 4.9 6.8 14.2 10.0 13.2 8.3 11.4 8.9 8.3 8.5 13.8 12.5 11.5 13.2 10.8 4.3 13.3 14.2 15.4 26.7 16.5 16.1 20.6 6.8 10.1 11.2 8.0 9.8 18.9 11.4 10.3 21.7 14.0 20.0 11.9 15.4 10.6 12.3 10.4 12.8 9.4 9.7 5.8 9.4 8.9 7.4 16.1 12.5 8.6 11.2 26.8 16.2 9.9 11.1 6.5 9.5 16.4 11.4 7.4 16.8 12.6 14.9 9.8 10.5 12.3 26.0 8.8 11.6 13.5 7.9 0.4 1.9 3.1 2.8 2.8 4.0 1.8 2.5 2.1 1.4 1.8 2.4 2.3 4.5 2.8 2.3 2.1 2.2 1.3 6.1 6.9 6.4 7.7 10.4 7.1 2.8 4.3 2.6 3.6 6.8 4.9 10.9 28.9 11.3 35.6 12.9 11.6 10.5 13.7 19.9 47.1 11.6 7.9 7.3 11.5 12.7 5.5 68.8 6.9 12.6 12.2 1.9 9.6 130.6 37.4 17.9 12.2 22.8 7.8 69.4 7.0 9.0 10.3 15.3 24.6 3.8 15.8 10.4 4.4 10.4 10.1 49.8 10.5 6.1 9.7 10.0 261.1 6.2 14.1 7.2 40.3 13.5 7.9 5.2 40.2 41.3 12.0 7.5 10.1 14.3 11.1 8.2 9.7 23.3 29.3 6.6 14.4 11.8 31.9 19.8 26.7 15.6 4.1 13.2 7.9 10.4 13.2 CSNK1G2 CK1g2 ENSG00000133275 "Casein kinase 1 gamma 2" P78368 19 1941172-1981338 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Early spermatids: 254.8;Late spermatids: 613.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034868, HPA056572" Uncertain Approved Vesicles NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 25: Spermatids - Spermatogenesis" Vesicles "HPA034868: AB_10671235, HPA056572: AB_2683178" "unprognostic (2.00e-1)" "unprognostic (2.15e-1)" "unprognostic (1.83e-1)" "unprognostic (2.42e-3)" "unprognostic (6.51e-3)" "unprognostic (2.27e-3)" "unprognostic (1.14e-3)" "unprognostic (2.00e-1)" "unprognostic (9.42e-2)" "unprognostic (5.78e-2)" "unprognostic (4.83e-3)" "unprognostic (4.09e-3)" "unprognostic (7.95e-2)" "unprognostic (4.65e-3)" "unprognostic (5.09e-1)" "unprognostic (2.01e-1)" "unprognostic (1.63e-2)" 37.1 52.7 19.3 40.5 17.9 47.3 38.3 22.8 28.1 35.1 18.3 35.0 29.5 34.5 6.5 50.6 35.7 20.6 33.8 21.6 16.6 42.6 41.6 53.5 41.8 20.8 19.2 39.5 39.8 13.3 51.5 17.7 18.1 41.3 8.7 9.8 38.1 14.0 39.4 45.1 46.9 10.3 12.8 69.2 35.5 99.9 18.3 23.5 35.8 12.3 18.7 32.3 37.8 18.1 71.2 37.3 51.0 80.1 17.5 32.6 42.7 43.1 28.0 32.0 39.1 31.0 37.8 44.3 35.2 27.6 17.8 50.1 27.6 52.5 14.0 40.5 60.4 31.2 65.0 52.9 28.2 50.7 76.3 32.5 33.8 33.4 21.3 24.7 38.4 54.2 67.1 146.5 21.4 41.3 101.0 66.8 92.7 19.7 41.8 86.8 32.3 72.7 24.3 73.2 81.9 67.4 32.2 52.7 48.2 18.8 33.6 81.8 46.6 40.2 31.5 85.3 50.6 94.8 54.5 55.5 40.7 47.6 42.8 2.8 3.6 4.7 4.2 5.8 3.0 3.4 3.1 3.6 3.6 3.3 2.4 3.4 10.0 3.5 14.4 5.4 2.4 2.4 19.3 17.9 22.8 28.1 21.6 16.6 20.8 19.2 18.1 12.8 18.3 18.1 37.5 16.0 17.9 10.1 36.5 21.9 17.8 14.9 10.8 43.6 28.9 26.8 14.2 10.0 14.9 11.0 41.7 12.2 91.7 36.9 9.8 17.1 254.8 37.7 32.5 24.7 30.5 12.6 10.8 29.5 18.9 21.6 31.1 32.4 29.9 41.8 16.8 16.4 14.9 25.2 9.8 26.6 6.1 21.9 30.3 613.6 20.5 32.3 14.2 14.0 16.4 21.6 41.2 5.5 6.2 30.1 24.0 18.8 38.2 28.8 15.0 14.6 22.8 39.3 13.1 26.4 23.0 16.0 13.2 19.0 25.3 18.2 46.2 51.7 24.8 32.8 CSNK1G3 ENSG00000151292 "Casein kinase 1 gamma 3" Q9Y6M4 5 123512099-123617045 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027010 Approved NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 9: Intestine - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 44: Endometrium - Transcription" "HPA027010: AB_10602803" "unprognostic (1.28e-1)" "unprognostic (1.88e-1)" "prognostic favorable (9.90e-5)" "unprognostic (1.60e-2)" "unprognostic (1.23e-1)" "unprognostic (3.07e-1)" "unprognostic (3.12e-3)" "unprognostic (1.68e-1)" "unprognostic (1.06e-1)" "unprognostic (1.18e-3)" "unprognostic (9.92e-3)" "unprognostic (4.92e-1)" "unprognostic (1.05e-2)" "unprognostic (3.44e-1)" "unprognostic (2.52e-1)" "unprognostic (1.97e-3)" "unprognostic (4.38e-1)" 13.5 12.0 8.1 13.6 9.5 11.6 15.2 13.5 9.7 12.2 6.5 21.9 21.4 15.7 10.5 16.3 12.6 15.2 10.1 9.4 9.9 14.2 25.2 13.6 14.4 6.9 7.9 15.0 9.9 15.1 6.4 14.6 8.3 10.9 24.1 7.6 9.1 9.2 5.7 9.4 23.1 16.3 7.3 13.0 16.6 15.3 9.7 14.4 14.2 8.0 16.3 20.1 10.1 7.7 28.3 26.7 39.2 37.4 39.0 43.3 19.4 29.9 35.7 32.4 48.2 24.0 44.0 0.0 37.9 36.2 37.7 20.1 31.7 59.2 55.6 42.7 21.8 19.9 29.8 25.6 34.7 10.5 19.7 37.1 37.7 36.7 68.8 38.5 35.9 13.7 11.3 22.2 27.7 19.6 14.2 13.0 22.1 22.2 18.2 15.8 41.4 27.0 24.3 30.6 33.9 24.5 33.3 21.8 50.1 32.4 28.6 29.1 33.2 47.5 35.6 29.1 33.5 24.7 29.0 25.1 28.4 29.8 31.4 12.4 5.7 2.5 6.3 5.4 8.6 12.4 5.3 5.6 5.2 11.9 5.4 5.8 4.4 13.4 6.1 4.5 7.3 4.9 8.1 9.5 13.5 9.7 9.4 9.9 6.9 7.9 8.3 7.3 9.7 7.7 42.4 22.4 14.1 40.5 54.9 20.6 25.6 19.6 33.0 30.1 25.3 22.2 20.6 7.2 18.0 11.0 8.4 8.6 38.3 35.2 21.5 23.7 10.9 26.3 29.9 30.7 32.8 5.9 75.4 25.0 15.2 31.8 25.5 31.8 5.7 29.9 29.3 23.4 9.6 90.9 74.8 27.2 22.4 17.3 18.0 15.8 19.9 20.5 16.0 65.6 32.0 26.2 39.1 97.0 54.5 30.5 42.8 19.5 38.5 28.5 33.9 22.2 18.8 3.3 0.0 28.2 27.8 26.6 53.7 24.8 18.8 6.7 32.7 21.7 23.9 43.2 CSNK2A1 "Cka1, Cka2" ENSG00000101266 "Casein kinase 2 alpha 1" P68400 20 472498-543835 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Biological rhythms, Cell cycle, Transcription, Transcription regulation, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB020680, HPA059206, HPA061698, CAB069395" Supported Supported Nucleoplasm NA NA "Cluster 34: Basophils - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" Nucleoplasm "CAB020680: , CAB069395: AB_1611912, HPA059206: AB_2683948, HPA061698: AB_2732667" "unprognostic (1.19e-1)" "unprognostic (1.44e-1)" "unprognostic (5.44e-2)" "unprognostic (8.28e-3)" "unprognostic (3.62e-2)" "unprognostic (2.04e-2)" "prognostic unfavorable (4.11e-6)" "unprognostic (4.08e-2)" "unprognostic (3.89e-1)" "unprognostic (6.88e-2)" "unprognostic (1.94e-2)" "unprognostic (1.16e-1)" "unprognostic (8.58e-2)" "unprognostic (1.50e-1)" "unprognostic (4.47e-1)" "unprognostic (9.53e-2)" "unprognostic (7.37e-2)" 36.1 32.6 20.9 38.6 23.2 34.0 35.9 28.2 29.6 36.5 29.3 48.3 39.1 35.8 26.6 50.0 39.9 31.3 54.0 25.7 21.0 41.0 31.8 31.6 41.2 20.6 21.1 41.5 46.9 59.1 21.2 42.4 21.1 35.8 40.7 32.9 41.1 37.7 110.5 34.2 40.5 39.1 18.8 30.2 49.5 65.2 22.3 51.6 39.6 86.4 46.6 47.4 28.5 27.3 209.5 170.4 152.9 96.0 61.1 103.8 103.5 117.9 116.1 125.8 139.5 178.5 120.0 179.1 74.2 90.1 179.1 147.8 162.1 167.4 187.2 62.6 57.7 247.3 44.7 177.7 102.5 228.1 51.3 99.5 173.3 105.8 316.0 122.2 139.5 146.4 248.9 112.6 123.8 64.2 262.0 73.7 227.4 173.4 97.6 149.8 140.5 140.9 112.9 128.5 163.9 132.3 97.2 184.0 174.8 120.7 120.4 83.9 142.7 136.0 118.4 90.0 178.5 120.6 311.8 174.1 65.8 119.5 138.6 40.5 23.8 28.7 18.2 32.3 22.4 23.0 18.0 17.6 31.5 22.5 17.9 17.4 14.9 25.1 33.5 25.7 20.4 20.8 20.9 23.2 28.2 29.6 25.7 21.0 20.6 21.1 21.1 18.8 22.3 27.3 50.7 64.1 84.6 51.9 46.1 41.0 40.0 43.8 45.5 49.4 42.1 36.1 59.4 41.5 75.8 44.1 31.3 42.2 50.5 43.5 41.1 68.5 135.5 67.6 77.0 44.5 35.2 59.3 65.6 50.6 54.4 46.3 40.2 75.7 63.8 108.6 27.1 31.1 33.2 60.6 69.3 41.8 46.8 39.2 30.3 140.0 41.0 45.3 14.2 51.5 61.7 38.6 37.0 73.9 73.6 66.6 34.4 36.9 49.6 57.2 43.2 68.8 65.5 27.8 52.6 43.6 56.8 94.2 68.7 52.3 50.2 61.4 38.9 81.2 40.6 59.4 CSNK2A2 "CK2alpha', CSNK2A1" ENSG00000070770 "Casein kinase 2 alpha 2" P19784 16 58157907-58198106 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle, Transcription, Transcription regulation, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 112.7" "Group enriched" "Detected in all" 5 "Early spermatids: 227.4;Late spermatids: 281.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA 92000 "Cluster 46: Basophils - DNA binding" "Cluster 27: Brain & Skin - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 34: Spermatids - Unknown function" "unprognostic (9.49e-2)" "unprognostic (1.87e-1)" "unprognostic (5.45e-2)" "unprognostic (1.23e-1)" "unprognostic (2.08e-1)" "prognostic unfavorable (1.40e-5)" "prognostic unfavorable (1.80e-4)" "unprognostic (6.84e-3)" "unprognostic (2.93e-3)" "unprognostic (2.40e-1)" "unprognostic (3.03e-2)" "unprognostic (1.63e-1)" "unprognostic (5.89e-2)" "unprognostic (2.06e-3)" "unprognostic (7.07e-2)" "unprognostic (3.23e-1)" "unprognostic (3.14e-2)" 21.0 14.1 19.3 9.0 20.2 6.4 19.0 18.9 22.1 23.0 23.7 32.1 10.0 21.0 29.0 15.7 20.3 14.1 21.2 20.0 19.7 17.3 15.9 16.2 14.2 19.1 20.4 32.4 34.2 23.9 15.7 15.5 19.2 15.5 12.4 13.5 17.0 16.7 41.1 64.8 14.2 21.9 19.8 12.6 27.9 112.7 20.3 18.3 18.0 26.8 17.3 24.2 19.6 19.9 28.1 35.3 24.5 19.1 46.2 62.5 27.6 24.7 41.8 47.7 30.7 64.0 23.2 44.2 38.8 29.6 18.9 29.2 41.6 37.2 53.4 16.9 28.3 23.4 18.0 56.1 66.5 32.6 20.5 66.9 88.9 33.8 65.9 62.0 45.4 43.6 53.4 15.1 31.0 15.8 41.2 21.9 23.4 16.6 45.7 48.4 38.7 25.7 33.1 28.7 20.5 18.4 39.7 20.3 63.6 41.9 13.9 24.6 33.6 27.8 33.7 23.3 25.7 36.2 30.2 63.2 24.3 21.8 24.4 1.1 0.2 0.3 0.7 0.1 0.4 0.6 1.1 0.4 0.2 0.6 1.8 1.3 0.0 0.7 0.1 1.9 0.0 0.1 19.3 20.2 18.9 22.1 20.0 19.7 19.1 20.4 19.2 19.8 20.3 19.9 30.6 12.8 22.5 19.2 16.7 29.6 10.9 13.0 8.6 24.0 19.3 19.9 24.4 12.8 7.6 9.2 4.2 15.9 28.3 16.4 7.9 14.5 227.4 24.7 37.8 25.8 16.8 10.3 27.7 17.2 26.1 17.7 8.6 29.5 8.2 37.0 19.6 17.0 16.9 18.5 19.1 11.9 4.1 25.5 23.0 281.0 14.3 23.1 12.4 20.6 14.2 25.3 18.6 20.6 26.1 25.0 11.5 19.5 9.2 18.1 16.0 16.3 13.4 21.7 13.1 29.2 23.2 48.1 36.8 12.6 29.0 24.5 20.3 35.6 17.5 23.0 CSNK2B "Ckb1, Ckb2" ENSG00000204435 "Casein kinase 2 beta" P67870 6 31665227-31670343 "Cancer-related genes, Disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Wnt signaling pathway" "Cancer-related genes, Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB004349, HPA005944, CAB013087, CAB016059" Approved NA NA 83000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 72: Non-specific - Transcription" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 39: Non-specific - Basic cellular processes" "CAB004349: AB_626791, CAB013087: AB_2533571, CAB016059: AB_626792, HPA005944: AB_1847290" "unprognostic (1.61e-1)" "unprognostic (3.21e-2)" "unprognostic (8.88e-2)" "unprognostic (1.55e-3)" "unprognostic (9.51e-2)" "unprognostic (1.38e-1)" "unprognostic (3.03e-3)" "unprognostic (1.60e-1)" "unprognostic (7.52e-2)" "unprognostic (1.62e-3)" "unprognostic (1.19e-1)" "unprognostic (1.19e-1)" "prognostic unfavorable (1.06e-5)" "unprognostic (5.88e-2)" "unprognostic (1.72e-1)" "unprognostic (9.67e-2)" "unprognostic (3.72e-2)" 155.8 157.4 15.8 31.9 24.6 62.2 150.2 17.6 54.1 147.9 16.8 142.2 27.8 126.7 183.7 166.6 130.1 33.1 178.9 15.9 16.4 172.1 163.7 133.0 72.5 16.3 17.5 161.2 142.3 69.3 130.0 68.2 17.8 120.3 50.4 41.4 131.9 57.6 232.0 294.2 126.5 66.3 15.4 146.0 146.7 257.9 17.1 56.5 132.4 94.8 30.1 126.2 139.8 17.4 0.9 95.5 2.5 164.9 97.4 158.0 120.8 200.9 350.2 407.6 377.9 0.2 129.3 302.5 127.9 196.8 146.0 0.1 1.0 374.5 409.4 153.1 322.6 4.3 0.6 1.1 260.0 341.5 0.9 257.8 1.5 0.8 0.2 0.2 4.7 208.3 1.7 1.7 0.8 2.9 237.1 2.2 102.0 240.0 0.0 221.1 2.3 247.7 222.3 136.5 1.2 243.0 1.8 0.9 175.8 101.0 7.4 1.3 118.8 210.3 203.9 198.0 1.3 167.3 285.9 267.6 122.3 1.6 196.1 87.3 114.8 121.8 80.1 125.9 80.5 113.7 81.7 85.1 111.0 99.1 71.4 61.9 95.2 90.8 83.2 131.7 113.4 95.0 15.8 24.6 17.6 54.1 15.9 16.4 16.3 17.5 17.8 15.4 17.1 17.4 114.3 51.3 67.0 11.1 124.4 186.1 125.1 196.1 138.9 56.8 135.5 196.3 91.3 105.8 116.5 101.2 12.5 211.8 106.4 185.6 270.1 184.7 452.7 75.1 71.7 122.7 125.7 103.5 14.1 175.2 252.7 118.3 93.3 68.2 129.5 102.3 125.7 126.6 296.2 48.8 14.3 175.4 138.4 204.4 218.5 270.7 153.7 146.2 152.9 8.4 181.1 168.3 121.5 14.6 19.1 182.9 248.1 125.3 152.1 154.3 283.1 397.5 91.3 47.8 138.1 107.9 152.2 485.6 186.5 142.7 186.3 282.1 111.5 116.8 184.3 150.6 CTDP1 FCP1 ENSG00000060069 "CTD phosphatase subunit 1" Q9Y5B0 18 79679803-79754510 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Hydrolase, Protein phosphatase" "Cataract, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 4 "Early spermatids: 113.1;Late spermatids: 123.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "eosinophil: 3.2" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032641, HPA040394, HPA070389" Approved Approved Nucleoplasm,Vesicles NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 71: Testis - DNA repair" "Cluster 24: NB-4 - Immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Nucleoplasm Vesicles "CAB032641: AB_2261235, HPA040394: AB_10794029, HPA070389: AB_2732155" "unprognostic (1.71e-1)" "unprognostic (1.75e-1)" "unprognostic (1.37e-1)" "prognostic favorable (6.43e-4)" "unprognostic (2.64e-2)" "unprognostic (7.99e-2)" "unprognostic (3.47e-3)" "unprognostic (1.83e-1)" "unprognostic (2.54e-1)" "unprognostic (1.15e-1)" "unprognostic (5.21e-3)" "unprognostic (1.99e-2)" "prognostic favorable (5.51e-5)" "unprognostic (5.16e-2)" "unprognostic (8.58e-2)" "unprognostic (2.85e-2)" "unprognostic (4.74e-2)" 9.3 7.4 3.8 7.2 3.9 13.7 8.9 3.3 4.2 7.8 4.1 11.1 7.2 10.4 1.4 10.7 8.1 4.0 7.2 3.3 3.3 7.9 9.5 9.3 8.7 5.3 4.2 5.0 9.0 3.3 6.9 4.2 4.0 8.2 3.1 1.5 9.5 3.9 11.9 20.5 10.9 3.1 3.3 13.5 9.9 22.2 4.0 6.5 8.0 3.1 3.7 9.6 8.6 4.4 13.4 14.0 7.7 11.0 6.0 5.0 25.9 9.6 6.1 7.6 7.5 9.4 8.0 17.2 4.2 5.6 9.1 16.4 6.6 8.8 3.1 16.9 12.4 8.5 6.6 12.9 8.7 37.6 20.5 8.4 8.3 8.1 3.8 4.6 9.2 12.2 11.2 8.1 3.0 11.5 25.4 29.5 12.7 4.2 19.1 20.7 10.1 20.0 5.6 13.1 12.0 12.4 10.2 9.8 13.9 5.8 8.0 21.7 12.9 12.9 19.4 5.3 9.7 7.4 27.6 16.1 11.0 18.8 9.3 0.0 0.4 3.2 0.5 0.4 0.4 0.2 0.4 0.8 0.6 0.1 0.5 0.3 1.0 1.1 0.4 0.1 0.1 0.2 3.8 3.9 3.3 4.2 3.3 3.3 5.3 4.2 4.0 3.3 4.0 4.4 7.4 0.0 4.1 3.6 9.2 8.5 5.0 4.0 11.4 9.5 7.7 6.5 3.8 4.3 4.5 3.7 14.6 8.8 24.2 20.0 1.9 5.4 113.1 18.6 8.0 7.5 6.0 13.5 7.7 7.2 8.0 4.8 19.9 24.0 7.0 7.8 6.4 5.7 8.8 23.5 6.6 16.6 6.1 7.5 9.5 123.2 7.8 13.8 7.2 6.5 6.5 6.5 19.6 3.0 8.9 10.2 14.9 10.5 15.2 11.8 10.0 6.8 9.6 14.8 0.0 5.9 7.4 18.0 10.5 10.5 10.1 19.0 18.3 8.0 11.7 12.6 CTDSP1 "NLIIF, SCP1" ENSG00000144579 "CTD small phosphatase 1" Q9GZU7 2 218398256-218405941 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "NK-cells: 184.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA062654 Supported Nucleoplasm NA NA "Cluster 10: Basophils - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 63: NK-cells & T-cells - Immune response" Nucleoplasm "HPA062654: AB_2684819" "unprognostic (1.97e-2)" "unprognostic (4.02e-2)" "unprognostic (1.67e-3)" "unprognostic (2.62e-2)" "unprognostic (1.49e-1)" "unprognostic (1.82e-2)" "unprognostic (3.90e-2)" "unprognostic (8.69e-2)" "unprognostic (2.98e-1)" "unprognostic (6.38e-2)" "unprognostic (3.70e-1)" "unprognostic (1.79e-1)" "unprognostic (2.58e-1)" "unprognostic (6.67e-2)" "unprognostic (2.62e-1)" "unprognostic (7.01e-2)" "unprognostic (1.57e-1)" 84.5 55.4 42.1 43.0 47.8 53.1 76.5 41.6 42.2 82.4 40.6 72.2 56.7 80.2 31.9 71.8 74.3 46.7 79.4 36.8 38.8 83.2 118.6 74.5 49.2 55.6 47.0 82.3 79.1 56.9 28.4 77.7 44.6 104.6 44.7 8.7 65.3 57.2 60.0 71.4 75.9 48.4 45.3 92.7 88.3 16.9 45.5 48.0 78.9 53.7 45.4 82.6 70.4 43.2 29.8 37.8 21.8 71.9 58.1 53.8 80.0 38.9 56.2 37.2 32.0 49.7 72.7 18.0 33.0 69.8 25.3 59.1 32.4 47.2 19.0 63.8 25.5 68.3 48.6 67.0 69.4 42.9 89.3 61.5 56.7 28.3 31.7 58.3 55.5 27.5 56.5 62.6 39.9 84.0 37.5 122.1 15.5 47.6 37.8 51.4 30.8 39.2 47.7 36.6 14.5 36.4 34.4 72.9 38.6 27.4 40.8 101.1 48.5 58.7 35.0 45.4 17.4 40.1 28.1 42.6 52.3 39.7 33.2 54.2 30.4 74.1 24.3 24.7 15.5 7.8 14.7 15.8 15.9 7.2 9.3 12.4 56.4 17.3 26.3 5.4 13.8 21.2 42.1 47.8 41.6 42.2 36.8 38.8 55.6 47.0 44.6 45.3 45.5 43.2 65.0 44.8 40.0 15.0 43.0 27.3 29.1 24.7 37.5 14.6 34.8 34.5 35.1 58.6 23.7 31.3 2.1 42.7 70.5 95.0 33.2 36.6 1.9 15.1 35.1 43.4 21.7 52.6 0.7 42.7 43.3 44.7 45.3 27.7 18.3 23.0 67.5 57.3 39.3 6.7 1.0 53.5 12.2 83.2 28.1 4.6 59.4 59.9 33.8 14.0 56.9 55.6 184.4 13.0 12.9 38.5 43.1 44.0 35.7 39.8 85.1 51.1 10.0 28.0 26.3 36.0 44.8 1.7 8.7 37.8 20.3 54.3 55.1 29.4 41.5 30.2 CTDSP2 "OS4, PSR2, SCP2" ENSG00000175215 "CTD small phosphatase 2" O14595 12 57819927-57846729 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 5 "RH-30: 1208.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA052607 Uncertain Approved Nucleoplasm,Mitochondria NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm Mitochondria "HPA052607: AB_2681883" "unprognostic (7.09e-2)" "unprognostic (2.45e-1)" "unprognostic (1.84e-2)" "unprognostic (3.07e-2)" "unprognostic (4.39e-1)" "unprognostic (5.57e-2)" "unprognostic (1.05e-3)" "unprognostic (2.45e-2)" "unprognostic (1.04e-1)" "unprognostic (1.06e-2)" "unprognostic (1.12e-1)" "unprognostic (4.15e-1)" "unprognostic (7.38e-3)" "unprognostic (5.50e-2)" "unprognostic (6.50e-2)" "unprognostic (2.18e-1)" "unprognostic (3.11e-1)" 90.9 82.5 66.8 65.4 80.0 45.7 81.8 79.7 69.3 84.0 61.0 108.9 54.3 96.4 51.4 67.0 89.9 64.7 72.4 64.6 63.0 66.2 58.8 113.9 66.1 90.7 80.6 107.3 119.4 68.2 40.3 94.3 76.5 70.1 83.2 30.1 109.1 82.8 122.3 88.9 77.0 94.8 71.4 75.5 89.9 32.3 74.3 104.8 68.1 102.8 77.5 85.2 71.8 83.4 83.1 35.4 165.6 105.8 145.6 248.8 55.0 87.4 165.1 85.2 75.4 45.6 131.5 101.3 98.1 187.5 33.2 64.8 70.0 85.3 88.8 34.2 29.7 140.3 54.4 37.0 135.4 64.3 78.3 239.7 88.9 77.3 65.1 181.9 135.0 60.6 74.5 172.9 43.4 38.2 69.1 38.3 84.3 52.5 44.4 91.0 1208.7 133.2 66.2 118.6 31.1 68.3 122.1 69.4 105.3 100.2 125.8 110.4 109.3 75.0 80.8 85.6 31.5 51.4 59.6 120.3 84.4 58.5 59.7 12.6 9.1 14.4 6.1 8.5 7.2 6.6 8.6 7.1 8.7 6.0 9.8 7.6 17.2 8.2 7.6 7.2 6.2 7.4 66.8 80.0 79.7 69.3 64.6 63.0 90.7 80.6 76.5 71.4 74.3 83.4 50.9 73.7 42.7 31.3 28.5 67.6 45.2 34.6 51.8 19.0 51.2 36.6 34.0 78.6 27.6 47.8 16.7 43.7 48.8 151.1 15.6 72.9 52.2 33.4 51.2 59.3 48.7 50.1 15.8 135.0 41.4 51.0 20.4 50.1 24.7 44.2 86.4 59.1 42.3 20.2 11.0 39.4 16.2 76.1 43.5 151.9 51.9 39.5 42.7 16.9 81.9 44.4 42.2 17.6 27.9 105.8 49.3 48.5 30.3 70.4 57.5 30.6 18.4 11.2 72.3 49.2 53.3 6.3 25.1 39.6 76.1 56.2 34.3 34.8 37.3 99.2 CTDSPL "C3orf8, HYA22, PSR1, RBSP3, SCP3" ENSG00000144677 "CTD small phosphatase like" O15194 3 37861880-37984469 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 170.4;Excitatory neurons: 189.3;Inhibitory neurons: 126.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "hTCEpi: 132.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA048325 Approved Approved Nucleoplasm,Vesicles NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 31: Skin - Epidermis development" "Cluster 30: Epithelial cell lines - Translation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Vesicles Nucleoplasm "HPA048325: AB_2680359" "unprognostic (7.35e-2)" "unprognostic (1.36e-1)" "unprognostic (1.21e-1)" "unprognostic (6.48e-3)" "unprognostic (1.73e-1)" "unprognostic (3.35e-2)" "unprognostic (1.66e-3)" "unprognostic (4.30e-2)" "unprognostic (1.96e-1)" "unprognostic (2.55e-1)" "unprognostic (2.98e-3)" "unprognostic (1.20e-1)" "prognostic favorable (6.22e-14)" "unprognostic (3.48e-2)" "unprognostic (6.84e-2)" "unprognostic (1.94e-1)" "unprognostic (2.67e-2)" 21.1 9.2 19.4 6.3 20.6 10.0 28.1 24.3 23.2 20.3 17.1 33.4 14.3 20.2 14.0 23.8 17.9 29.3 29.4 18.8 17.3 39.7 21.5 27.2 4.1 19.2 17.7 19.6 15.8 12.0 10.7 31.7 16.6 26.5 30.2 3.2 27.1 31.3 21.2 52.9 17.6 23.2 18.1 17.3 31.7 10.6 19.5 7.2 14.0 19.9 5.5 26.4 19.1 17.3 44.5 18.9 7.6 24.0 29.2 41.0 57.2 30.0 37.0 20.1 23.5 27.4 35.3 0.2 17.9 36.9 8.4 36.3 19.2 56.1 16.0 0.1 15.1 27.2 18.8 63.1 26.4 0.0 6.4 21.5 132.3 21.2 25.5 22.4 28.2 12.0 8.9 0.0 33.7 13.7 11.1 0.1 31.5 17.7 2.7 12.3 14.9 0.2 63.3 28.7 6.3 19.9 16.5 28.7 33.5 30.5 28.1 7.3 23.2 14.4 20.4 27.3 19.1 0.6 0.2 0.2 15.8 14.8 27.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.4 0.0 0.0 0.0 0.0 2.1 19.4 20.6 24.3 23.2 18.8 17.3 19.2 17.7 16.6 18.1 19.5 17.3 26.8 67.3 27.6 170.4 1.2 30.1 17.0 17.7 27.9 10.1 25.7 59.4 42.2 65.8 25.7 23.9 0.0 34.7 1.0 35.6 23.5 14.2 21.5 7.6 17.6 22.4 45.2 7.8 189.3 4.7 9.9 32.4 10.2 27.2 1.3 15.7 22.9 18.1 7.2 10.1 126.3 18.5 2.0 13.3 6.5 51.3 71.7 11.3 8.8 22.5 1.4 9.5 1.0 87.4 48.8 14.2 17.9 98.2 0.4 15.5 9.1 19.7 12.4 1.7 26.3 55.4 40.4 10.0 16.9 17.7 28.7 9.4 2.0 65.8 42.0 14.4 CWC27 "NY-CO-10, SDCCAG-10, SDCCAG10" ENSG00000153015 "CWC27 spliceosome associated cyclophilin" Q6UX04 5 64768930-65018750 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Disease variant, Dwarfism, Mental retardation, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 255.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020344, HPA024149, HPA065809" Approved Enhanced Nucleoplasm NA NA "Cluster 44: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 29: Early spermatids - Spermatogenesis" Nucleoplasm "HPA020344: AB_1856644, HPA024149: AB_1856645, HPA065809: AB_2685561" "unprognostic (1.71e-1)" "unprognostic (6.47e-3)" "unprognostic (2.79e-2)" "unprognostic (1.80e-1)" "unprognostic (8.91e-2)" "unprognostic (4.00e-3)" "prognostic unfavorable (5.27e-6)" "unprognostic (1.58e-2)" "unprognostic (3.43e-2)" "unprognostic (1.21e-1)" "unprognostic (1.48e-2)" "unprognostic (2.04e-1)" "unprognostic (2.07e-1)" "unprognostic (2.46e-1)" "unprognostic (2.05e-1)" "unprognostic (2.74e-1)" "unprognostic (7.45e-3)" 13.4 13.0 13.6 13.0 14.6 20.5 13.4 16.7 18.4 12.6 10.7 14.3 9.8 15.5 12.3 11.8 11.8 11.2 18.9 13.1 15.5 14.1 10.2 10.7 15.4 14.5 13.7 18.2 9.0 16.9 8.8 14.6 14.4 13.9 15.0 14.0 10.5 12.3 22.2 11.5 10.1 14.3 13.5 12.8 11.1 17.2 14.1 21.7 13.9 26.4 16.0 13.2 11.5 15.4 32.7 21.4 37.5 69.9 31.4 38.2 41.8 33.5 27.7 36.7 38.2 36.0 40.3 48.0 57.0 35.0 41.2 20.2 39.8 60.5 66.2 40.4 32.4 36.2 35.6 30.3 48.0 38.3 23.5 25.6 45.7 46.3 58.3 32.3 39.4 53.9 35.8 30.8 36.8 32.6 53.5 34.7 30.4 16.9 25.6 49.0 50.4 50.3 35.0 28.0 44.4 19.6 40.8 16.4 39.7 35.5 35.9 55.5 32.9 21.4 37.8 34.6 54.2 23.9 33.1 46.5 40.1 65.9 38.8 13.2 13.1 9.6 13.6 13.2 16.8 17.5 15.3 17.4 16.9 13.2 16.2 16.9 2.7 20.4 10.2 13.8 18.0 10.4 13.6 14.6 16.7 18.4 13.1 15.5 14.5 13.7 14.4 13.5 14.1 15.4 24.2 9.6 26.2 64.3 26.0 16.4 27.7 37.5 13.6 31.4 17.4 20.3 63.6 18.6 23.2 14.7 14.6 44.0 16.8 11.6 21.5 44.1 255.6 21.0 27.2 27.2 29.9 37.8 114.1 33.1 54.5 25.1 13.7 20.2 19.6 40.7 16.4 11.4 33.0 20.2 110.3 17.0 40.7 17.1 15.2 57.9 38.5 22.3 14.2 61.8 33.6 34.2 36.0 103.0 103.2 40.4 16.0 36.1 21.0 22.1 13.3 24.4 28.6 51.3 32.9 31.3 33.6 74.2 28.3 20.6 20.0 30.8 26.2 30.7 28.6 23.8 CYLD "CYLD1, KIAA0849, USPL2" ENSG00000083799 "CYLD lysine 63 deubiquitinase" Q9NQC7 16 50742050-50801935 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Immunity, Innate immunity, Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 94.3" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 136.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011713, HPA050095" Approved Supported "Nucleoplasm,Centriolar satellite" Yes No "Cluster 10: Basophils - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 44: HDLM-2 - Immune response" "Cluster 24: Non-specific - Transcription regulation" "Centriolar satellite" Nucleoplasm "CAB011713: AB_731794, HPA050095: AB_2681013" "unprognostic (9.83e-2)" "unprognostic (1.17e-2)" "unprognostic (5.01e-2)" "unprognostic (2.83e-2)" "unprognostic (3.84e-1)" "unprognostic (5.06e-2)" "unprognostic (3.87e-2)" "unprognostic (3.24e-2)" "unprognostic (9.46e-2)" "unprognostic (1.11e-1)" "unprognostic (1.18e-2)" "unprognostic (2.32e-1)" "unprognostic (1.03e-1)" "unprognostic (1.07e-1)" "unprognostic (3.43e-2)" "unprognostic (6.83e-2)" "unprognostic (8.42e-2)" 14.3 22.0 23.9 38.8 23.5 94.3 13.6 17.9 18.2 13.0 22.3 16.3 16.1 15.1 12.1 23.3 11.0 20.5 20.1 17.3 23.3 14.2 21.0 21.5 53.4 21.3 27.8 15.4 15.2 23.0 15.4 15.4 23.6 16.3 19.3 22.0 18.9 16.0 34.3 15.2 16.2 16.8 21.6 39.0 19.9 38.3 32.7 35.6 24.9 20.5 48.4 24.1 12.9 24.2 26.9 8.3 9.4 10.6 14.3 21.0 8.7 39.1 56.7 39.9 23.4 6.9 12.5 30.7 13.7 38.3 43.4 10.3 11.3 23.7 58.7 136.6 16.6 15.5 15.3 5.8 29.1 15.4 69.5 23.0 18.6 48.1 50.1 37.7 16.3 21.3 6.6 26.1 56.4 4.0 14.4 22.3 10.1 8.5 13.3 13.4 18.8 29.4 12.9 9.1 12.0 9.2 33.1 11.2 9.8 14.3 11.0 18.9 18.6 67.2 15.4 23.4 15.9 68.0 68.4 33.2 49.3 16.7 14.7 64.6 15.2 38.3 18.1 17.7 21.8 17.2 27.1 24.5 18.3 11.1 24.4 19.4 32.3 25.7 18.8 11.0 37.3 19.5 23.9 23.5 17.9 18.2 17.3 23.3 21.3 27.8 23.6 21.6 32.7 24.2 28.8 44.8 31.8 31.6 87.7 120.1 59.5 32.2 40.9 89.2 35.5 26.0 34.4 21.5 32.9 18.4 93.8 6.8 84.1 28.3 5.9 20.0 48.2 22.5 24.9 36.0 31.1 26.1 51.9 19.1 4.4 37.3 22.4 47.1 80.5 21.4 27.8 25.5 21.5 67.3 54.7 10.7 30.5 40.0 127.6 31.3 25.4 66.4 74.7 57.1 63.7 23.3 70.0 51.8 119.2 18.0 22.4 21.1 79.7 66.4 15.4 13.9 23.3 48.3 6.6 54.2 30.5 59.2 15.2 64.3 155.6 4.1 119.5 21.3 14.8 66.7 DAPK1 "DAPK, ROCO3" ENSG00000196730 "Death associated protein kinase 1" P53355 9 87497228-87708634 "Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Apoptosis, Translation regulation" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 139.1;Excitatory neurons: 120.2;Inhibitory neurons: 155.9;Kupffer cells: 85.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "classical monocyte: 6.7;eosinophil: 8.7;intermediate monocyte: 14.0;myeloid DC: 4.8;non-classical monocyte: 15.2;plasmacytoid DC: 6.2" "Group enriched" "Detected in many" 56 "dendritic cells: 6.2;granulocytes: 8.7;monocytes: 15.2" "Cell line enhanced" "Detected in many" "HMC-1: 97.6;HUVEC TERT2: 56.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB037302, HPA040472, HPA048436" Approved Approved Centrosome NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 3: HMC-1 - Innate immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Centrosome "CAB037302: AB_1078622, HPA040472: AB_2677001, HPA048436: AB_2680390" "unprognostic (2.55e-1)" "unprognostic (1.47e-1)" "prognostic unfavorable (2.48e-5)" "unprognostic (2.77e-1)" "unprognostic (1.74e-1)" "unprognostic (3.47e-2)" "unprognostic (1.74e-1)" "unprognostic (1.75e-1)" "unprognostic (1.88e-2)" "unprognostic (5.77e-3)" "unprognostic (2.19e-2)" "unprognostic (2.77e-3)" "unprognostic (8.31e-3)" "unprognostic (8.76e-2)" "unprognostic (2.40e-1)" "unprognostic (1.68e-1)" "unprognostic (1.09e-3)" 22.9 5.9 12.1 11.8 16.4 5.4 5.9 2.2 20.5 9.6 12.6 27.1 10.1 7.9 18.8 5.5 15.2 28.0 5.2 22.8 7.6 22.0 27.6 37.5 12.5 7.6 7.6 46.0 29.2 6.7 23.4 27.3 13.8 5.2 9.2 11.5 13.7 8.5 1.8 5.0 14.4 9.4 7.8 22.8 19.5 8.1 8.6 41.8 9.8 2.3 6.8 14.5 3.8 7.5 0.0 47.5 22.5 15.8 0.7 0.3 35.4 3.1 4.4 18.3 20.4 6.8 0.3 0.4 4.7 1.0 0.2 43.9 13.9 1.0 7.9 0.4 11.4 23.4 6.6 23.7 19.5 0.0 97.6 1.4 7.5 3.5 1.4 28.5 56.3 6.5 17.8 9.6 15.4 1.5 7.0 0.0 25.4 44.4 0.0 2.0 19.8 0.1 50.6 47.6 10.2 11.3 0.0 4.6 20.1 32.7 0.0 15.2 0.4 0.1 0.3 0.1 0.1 36.9 8.1 0.0 0.2 6.4 3.0 1.7 6.7 8.7 0.0 14.0 0.0 0.1 0.0 0.0 4.8 0.0 0.0 0.1 2.0 0.1 15.2 6.2 0.0 3.0 12.1 16.4 2.2 20.5 22.8 7.6 7.6 7.6 13.8 7.8 8.6 7.5 8.8 51.3 72.2 139.1 2.7 3.6 0.8 1.2 0.6 19.4 1.3 2.3 2.4 31.5 24.3 22.0 2.1 6.8 9.5 1.1 1.9 33.8 1.8 30.2 7.9 17.3 0.0 12.8 120.2 23.0 19.0 12.3 26.5 58.6 24.1 22.1 68.9 20.8 22.7 18.5 155.9 9.3 0.0 85.7 18.3 3.1 14.9 57.1 12.4 18.7 41.2 14.6 2.1 6.6 4.7 35.8 1.9 13.5 6.2 3.2 9.6 7.0 10.2 2.9 0.0 1.5 3.9 3.4 7.2 1.6 3.1 14.2 2.8 3.4 3.7 14.9 DAPK2 "DRP-1, MGC119312" ENSG00000035664 "Death associated protein kinase 2" Q9UIK4 15 63907036-64072033 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Apoptosis "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 50.2;thyroid gland: 41.9" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 86.6;Late spermatids: 112.5;Oligodendrocytes: 99.9;Proximal enterocytes: 64.0" "Cancer enriched" "Detected in many" 15 "thyroid cancer: 30.3" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 14 "basophil: 94.3;eosinophil: 213.0;neutrophil: 65.9" "Lineage enriched" "Detected in many" 25 "granulocytes: 213.0" "Cell line enhanced" "Detected in many" "ASC diff: 10.6;HaCaT: 9.2;HMC-1: 18.3;MCF7: 9.7" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA071581 Supported "Golgi apparatus,Vesicles" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 3: HMC-1 - Innate immune response" "Cluster 31: Spermatids - Spermatogenesis" "Golgi apparatus, Vesicles" "HPA071581: AB_2686421" "unprognostic (3.20e-2)" "unprognostic (4.07e-2)" "unprognostic (4.23e-2)" "unprognostic (1.95e-3)" "unprognostic (2.88e-2)" "unprognostic (1.30e-2)" "unprognostic (2.32e-1)" "prognostic favorable (5.63e-4)" "unprognostic (1.04e-1)" "unprognostic (3.18e-1)" "unprognostic (9.21e-2)" "unprognostic (8.51e-2)" "unprognostic (4.77e-7)" "unprognostic (5.98e-2)" "unprognostic (1.45e-1)" "unprognostic (3.20e-3)" "unprognostic (9.07e-2)" 12.5 2.2 5.9 2.7 7.6 15.9 8.8 5.9 8.1 6.7 4.3 9.8 20.6 1.6 0.2 3.3 1.7 1.5 28.0 5.5 6.7 4.5 2.0 20.0 3.1 6.2 6.8 0.9 2.7 0.9 1.6 0.4 6.6 5.1 6.6 0.4 7.5 3.6 50.2 8.1 21.3 1.7 6.0 7.8 9.9 3.1 6.6 1.5 41.9 19.6 2.6 2.4 9.5 9.5 3.1 2.3 6.1 1.5 10.6 0.5 0.0 2.1 6.7 1.1 1.2 1.0 1.6 0.2 0.7 6.7 3.7 9.2 3.8 0.1 0.6 0.2 0.2 1.3 4.5 0.1 0.1 0.1 18.3 1.1 7.9 0.4 0.2 7.0 0.7 0.1 0.4 0.1 0.7 9.7 0.0 0.4 0.7 3.1 2.2 2.9 0.0 0.3 0.0 3.2 0.4 0.3 0.4 1.2 0.0 1.5 5.2 0.4 0.4 0.9 1.0 1.4 1.8 0.6 0.2 0.0 0.0 3.0 0.3 94.3 0.2 213.0 2.1 0.1 0.9 1.3 0.6 2.2 0.2 0.4 0.0 1.4 65.9 2.7 0.1 8.6 0.1 1.3 5.9 7.6 5.9 8.1 5.5 6.7 6.2 6.8 6.6 6.0 6.6 9.5 24.9 86.6 22.3 5.2 4.8 11.6 7.0 8.7 0.6 0.1 9.4 7.4 46.2 1.5 14.6 0.0 0.0 0.1 22.6 45.2 1.9 9.1 25.3 3.0 1.6 6.4 8.4 0.8 15.9 35.6 0.2 8.7 16.3 7.8 15.2 1.3 5.7 1.3 0.4 5.0 2.1 17.0 6.1 1.3 0.8 112.5 3.1 3.2 0.0 15.0 0.3 2.1 2.1 11.1 99.9 9.4 30.6 5.7 0.4 12.0 64.0 0.3 2.8 0.3 13.1 7.6 4.5 2.6 4.9 0.5 4.1 0.1 14.9 1.9 19.6 14.0 DAPK3 "ZIP, ZIPK" ENSG00000167657 "Death associated protein kinase 3" O43293 19 3958453-3971123 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Transcription, Transcription regulation, Translation regulation" "Activator, Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase" "Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA028569 Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 1: Pancreatic cells - Digestion" Cytosol Nucleoplasm "HPA028569: AB_10794319" "unprognostic (5.72e-2)" "unprognostic (3.28e-2)" "unprognostic (3.34e-3)" "prognostic favorable (2.01e-5)" "unprognostic (1.83e-1)" "unprognostic (2.37e-1)" "unprognostic (7.72e-3)" "unprognostic (2.16e-1)" "unprognostic (2.46e-2)" "unprognostic (4.95e-2)" "unprognostic (1.84e-3)" "unprognostic (7.64e-2)" "prognostic unfavorable (6.49e-4)" "unprognostic (9.92e-2)" "unprognostic (1.41e-1)" "unprognostic (5.48e-2)" "unprognostic (2.14e-1)" 49.9 25.4 15.0 29.0 15.2 18.9 47.2 14.3 27.9 58.3 18.9 92.2 30.9 85.0 8.2 37.0 55.4 36.0 106.2 16.8 13.9 27.6 30.4 72.5 21.2 16.2 15.4 48.4 36.4 19.0 38.5 31.9 18.8 53.3 11.0 9.0 41.3 39.3 113.6 51.2 44.4 36.6 11.9 29.6 61.4 42.6 17.4 15.4 31.0 21.1 11.3 59.5 45.3 17.3 79.2 61.1 37.5 47.6 27.5 30.9 57.8 106.0 84.5 84.7 55.5 113.4 23.3 43.4 50.8 93.8 59.6 61.7 36.9 60.3 30.7 64.0 61.2 17.5 76.7 65.9 87.2 42.7 63.1 70.6 73.6 77.0 44.0 50.8 71.2 29.2 56.3 73.2 52.5 51.0 42.4 31.9 58.5 31.8 48.6 52.5 55.3 40.5 51.0 60.9 59.1 41.1 71.4 84.9 61.1 43.8 61.4 33.1 134.8 108.3 49.3 98.1 134.5 81.1 72.4 50.7 86.3 44.0 59.0 32.5 18.0 32.5 23.0 20.3 16.7 15.9 17.8 21.6 16.2 16.6 13.1 12.9 29.8 24.3 14.3 18.6 23.6 14.6 15.0 15.2 14.3 27.9 16.8 13.9 16.2 15.4 18.8 11.9 17.4 17.3 24.1 25.6 10.5 6.5 17.0 100.7 99.7 84.1 27.9 15.2 23.9 15.6 29.2 24.3 35.0 11.0 2.1 50.5 14.5 69.2 17.6 90.3 40.3 27.9 28.2 38.3 27.4 7.0 9.6 88.2 79.1 27.8 40.8 37.5 20.3 24.8 21.4 7.9 22.9 11.8 7.1 48.2 48.8 13.6 22.8 23.6 22.7 16.6 37.4 8.4 25.7 12.8 30.9 6.0 6.7 117.7 49.9 22.6 13.3 46.1 59.6 14.3 18.8 10.7 32.9 19.9 53.0 34.6 15.7 24.4 71.7 93.2 15.1 26.2 29.7 46.3 DCLK1 "DCAMKL1, DCDC3A, DCLK, KIAA0369" ENSG00000133083 "Doublecortin like kinase 1" O15075 13 35768652-36131382 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Differentiation, Neurogenesis" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 53.0" "Group enriched" "Detected in many" 6 "Excitatory neurons: 970.6;Inhibitory neurons: 664.8" "Cancer enhanced" "Detected in many" "glioma: 12.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC diff: 29.0;ASC TERT1: 27.3;fHDF/TERT166: 23.5;GAMG: 34.8;HAP1: 17.9;HSkMC: 25.5;NTERA-2: 37.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB012405, HPA015040, HPA015655" Enhanced Approved Nucleoplasm,Cytosol NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm Cytosol "CAB012405: , HPA015040: AB_2669141, HPA015655: AB_2669265" "unprognostic (2.29e-1)" "unprognostic (2.56e-1)" "unprognostic (7.45e-2)" "unprognostic (1.30e-2)" "unprognostic (1.99e-1)" "unprognostic (2.35e-2)" "unprognostic (1.48e-1)" "unprognostic (3.30e-2)" "unprognostic (1.66e-1)" "unprognostic (1.74e-1)" "unprognostic (7.72e-2)" "unprognostic (2.85e-1)" "prognostic unfavorable (4.42e-4)" "unprognostic (1.93e-3)" "unprognostic (1.29e-1)" "unprognostic (1.34e-1)" "unprognostic (1.14e-4)" 15.5 2.5 22.0 4.0 27.5 0.0 14.2 10.2 45.3 11.8 0.0 4.2 1.1 6.0 4.1 5.4 4.6 7.2 5.5 37.1 37.8 2.8 0.1 2.4 4.2 17.9 13.2 6.1 1.2 1.1 13.7 0.1 53.0 4.1 3.8 17.3 3.4 4.0 2.1 8.4 4.1 19.1 15.7 4.5 3.6 1.3 17.5 1.6 2.8 4.6 2.2 4.3 5.9 18.7 0.0 0.4 6.8 0.0 29.0 27.3 0.0 0.2 0.4 0.2 0.2 0.0 0.1 0.0 0.0 23.5 34.8 0.0 17.9 0.3 0.0 0.0 1.0 0.0 0.8 0.0 1.1 0.0 0.0 25.5 13.0 0.6 0.4 0.0 0.2 0.0 0.0 0.1 0.3 0.1 0.0 0.0 37.1 0.0 0.4 0.0 2.0 0.0 1.0 0.0 7.3 4.4 0.0 0.0 2.2 10.4 0.0 0.0 0.0 0.1 6.1 7.6 1.3 0.1 0.0 0.0 2.4 0.0 7.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 22.0 27.5 10.2 45.3 37.1 37.8 17.9 13.2 53.0 15.7 17.5 18.7 8.0 9.6 0.6 132.2 0.1 15.2 1.3 1.8 0.0 9.4 7.8 7.0 5.8 0.0 7.9 3.7 4.2 0.0 0.0 0.0 0.0 0.1 1.5 0.7 1.7 3.8 0.0 0.0 970.6 0.0 0.0 82.6 0.5 0.3 0.0 75.5 0.4 0.0 0.1 10.1 664.8 0.0 4.1 0.3 14.7 1.6 20.8 0.7 14.2 44.0 0.0 73.8 0.0 31.2 19.1 0.2 0.0 4.1 0.3 0.6 0.0 0.6 3.1 4.2 6.6 10.8 22.0 1.3 1.4 1.0 9.7 0.0 0.8 30.1 0.0 1.7 DCLK2 "DCAMKL2, DCDC3, DCDC3B, DCK2, MGC45428" ENSG00000170390 "Doublecortin like kinase 2" Q8N568 4 150078445-150257438 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 59.0" "Group enriched" "Detected in many" 6 "Astrocytes: 501.1;Excitatory neurons: 189.8;Inhibitory neurons: 173.2;Oligodendrocyte precursor cells: 172.4" "Cancer enriched" "Detected in many" 17 "glioma: 53.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 23.6;BJ: 11.8;BJ hTERT+: 24.9;fHDF/TERT166: 11.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015770 Enhanced Approved NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 65: Brain - Ion transport" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 64: Astrocytes - Nervous system maintenance" "HPA015770: AB_1847509" "unprognostic (7.37e-2)" "unprognostic (1.56e-3)" "unprognostic (9.30e-2)" "unprognostic (1.49e-2)" "unprognostic (4.06e-1)" "unprognostic (6.24e-3)" "unprognostic (1.90e-1)" "unprognostic (7.38e-3)" "unprognostic (2.18e-1)" "prognostic favorable (3.25e-4)" "prognostic favorable (2.48e-4)" "unprognostic (6.87e-2)" "unprognostic (3.93e-3)" "unprognostic (3.74e-3)" "unprognostic (4.53e-2)" "unprognostic (1.48e-1)" "unprognostic (1.45e-2)" 1.7 2.8 45.8 0.9 42.0 0.5 1.4 34.6 43.6 2.0 7.7 5.6 1.4 2.7 2.0 1.5 1.9 2.5 12.2 59.0 41.2 2.3 0.6 2.1 0.4 41.2 46.6 2.9 2.2 0.6 8.3 1.5 38.4 2.7 2.0 18.4 0.8 2.0 1.2 1.0 2.2 4.7 46.6 1.2 2.3 2.8 42.7 0.2 2.6 1.4 0.3 2.6 1.3 46.8 1.2 4.2 23.6 3.7 0.0 1.1 0.4 11.8 24.9 3.5 0.9 0.1 0.0 0.0 0.4 11.0 3.6 0.1 3.5 0.0 4.4 5.1 2.1 0.0 7.0 0.0 5.0 0.7 0.7 0.6 0.0 2.2 0.2 2.2 1.2 0.6 0.0 0.1 2.5 0.2 0.4 0.0 0.5 0.3 1.6 0.0 2.8 1.0 0.1 1.0 9.2 9.1 4.7 3.4 1.0 2.0 0.0 0.1 2.1 3.3 1.3 2.2 1.3 1.1 0.0 0.1 3.1 0.2 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 45.8 42.0 34.6 43.6 59.0 41.2 41.2 46.6 38.4 46.6 42.7 46.8 10.7 0.0 0.0 501.1 0.6 0.5 0.1 0.0 0.6 26.2 2.8 2.2 10.5 1.5 0.7 3.7 16.7 0.0 0.0 0.8 0.0 0.4 0.1 0.4 4.6 7.6 3.0 0.0 189.8 0.7 0.0 3.4 1.1 0.5 4.5 5.7 7.5 0.0 1.6 35.3 173.2 0.3 0.0 0.6 3.4 0.3 1.8 0.7 5.4 43.1 0.2 31.2 0.0 172.4 37.6 0.1 0.4 3.8 0.3 0.6 0.0 0.4 0.1 9.6 13.1 5.6 9.2 0.1 2.0 0.1 0.6 0.3 0.9 6.6 1.4 0.2 DDAH1 DDAH ENSG00000153904 "Dimethylarginine dimethylaminohydrolase 1" O94760 1 85318481-85578363 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 131.8;kidney: 124.8" "Cell type enhanced" "Detected in many" "Astrocytes: 364.4;Excitatory neurons: 197.4;Oligodendrocyte precursor cells: 182.4;Proximal tubular cells: 283.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 239.4;LHCN-M2: 179.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006308, HPA071064" Enhanced Approved "Nucleoli,Plasma membrane,Cytosol" NA NA 350000 "Cluster 7: Kidney - Transmembrane transport" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane, Cytosol" Nucleoli "HPA006308: AB_1847532, HPA071064: " "unprognostic (1.44e-2)" "unprognostic (2.43e-1)" "prognostic favorable (5.99e-4)" "unprognostic (6.82e-2)" "unprognostic (1.04e-1)" "unprognostic (1.62e-2)" "unprognostic (2.55e-1)" "unprognostic (3.85e-2)" "unprognostic (2.57e-1)" "unprognostic (1.02e-2)" "unprognostic (3.62e-2)" "unprognostic (1.56e-1)" "prognostic favorable (5.21e-6)" "unprognostic (5.37e-2)" "unprognostic (9.06e-2)" "unprognostic (5.81e-2)" "unprognostic (1.56e-2)" 10.3 28.6 95.9 12.8 100.9 0.6 18.8 61.5 131.8 22.4 73.4 45.1 40.1 10.8 76.5 12.6 36.5 25.5 17.4 102.0 77.3 124.8 79.5 26.4 2.6 58.6 84.8 2.9 27.5 21.1 6.3 11.6 62.6 28.5 45.3 34.6 17.7 18.6 30.4 5.6 39.7 16.5 59.5 10.6 29.7 19.1 106.6 1.0 28.9 14.0 2.0 19.2 2.6 80.3 63.1 7.6 36.0 6.9 84.1 78.0 9.2 155.9 120.0 63.6 75.6 89.9 16.5 0.1 39.2 239.4 38.3 17.8 79.7 15.0 93.0 0.3 29.5 0.2 22.3 31.8 40.9 57.6 3.2 60.5 2.0 50.4 24.9 85.5 75.9 0.0 0.1 6.0 179.7 7.5 3.0 0.3 25.5 124.6 22.6 0.0 63.1 0.9 113.4 46.3 59.2 115.0 18.0 56.3 9.1 38.7 29.6 4.9 107.7 31.6 27.0 11.7 57.8 0.0 0.1 0.2 1.6 0.1 19.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 95.9 100.9 61.5 131.8 102.0 77.3 58.6 84.8 62.6 59.5 106.6 80.3 14.1 35.3 43.4 364.4 2.6 13.8 4.6 6.8 5.7 4.5 31.2 13.8 11.8 61.5 13.6 69.9 4.2 2.7 0.4 75.3 125.2 15.9 22.5 36.9 9.8 7.5 34.2 2.7 197.4 31.2 0.9 13.9 47.9 24.2 0.0 59.3 8.2 102.8 1.1 0.0 51.0 86.9 8.2 2.2 5.5 25.6 15.8 2.4 12.4 23.4 0.6 68.4 0.0 182.4 9.6 44.5 69.4 74.9 0.0 33.6 68.7 283.3 36.5 9.4 13.1 15.3 18.6 4.6 5.4 32.6 14.3 0.8 2.5 13.5 106.7 8.3 DDAH2 G6A ENSG00000213722 "Dimethylarginine dimethylaminohydrolase 2" O95865 6 31727038-31730617 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 386.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "MCF7: 63.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012389, HPA012509" Uncertain Supported Mitochondria NA NA 1500000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 89: Fibroblasts - ECM organization" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 53: Intestinal epithelial cells - Unknown function" Mitochondria "HPA012389: , HPA012509: AB_1847533" "unprognostic (2.29e-2)" "unprognostic (1.38e-1)" "unprognostic (4.49e-2)" "unprognostic (2.39e-1)" "unprognostic (1.44e-1)" "unprognostic (7.67e-2)" "unprognostic (1.50e-2)" "unprognostic (1.10e-1)" "unprognostic (2.62e-1)" "unprognostic (8.78e-2)" "unprognostic (1.01e-1)" "unprognostic (1.09e-1)" "unprognostic (1.02e-1)" "unprognostic (9.42e-2)" "unprognostic (2.32e-1)" "unprognostic (2.24e-2)" "unprognostic (2.72e-2)" 96.5 17.2 26.6 12.0 24.7 10.8 81.2 24.2 44.7 131.5 26.1 72.2 4.4 94.4 8.7 39.0 80.5 44.0 63.2 23.9 33.5 67.1 32.1 62.3 20.6 31.8 28.2 67.7 16.5 17.5 26.0 18.3 28.1 65.2 7.7 5.8 58.2 27.0 13.4 67.7 38.9 11.9 32.0 49.4 35.4 13.4 27.4 9.6 65.1 4.5 7.8 61.0 91.0 30.9 2.0 20.1 0.7 28.5 17.0 26.6 3.8 0.0 10.6 10.9 7.3 40.4 6.7 0.4 24.4 26.5 0.9 2.4 0.5 9.7 1.9 0.0 14.2 1.9 7.8 22.4 18.2 0.3 1.5 18.8 1.2 12.2 0.9 3.7 33.3 14.1 0.4 11.1 4.8 63.0 1.5 27.5 4.1 4.3 12.2 0.2 0.9 10.5 21.6 0.5 1.5 5.7 0.0 4.7 27.4 2.9 37.7 7.8 0.1 16.9 24.7 11.2 0.0 4.1 12.8 3.3 11.3 5.9 4.3 141.3 15.4 135.0 14.8 37.4 5.8 49.7 4.0 5.3 26.8 39.6 2.7 3.4 27.8 29.2 44.9 93.9 4.1 11.4 26.6 24.7 24.2 44.7 23.9 33.5 31.8 28.2 28.1 32.0 27.4 30.9 102.3 28.9 14.7 10.4 76.8 66.9 88.7 49.6 56.3 4.5 132.8 96.0 39.5 62.9 36.9 82.8 29.2 15.5 84.4 386.3 178.1 148.2 83.1 62.6 94.2 101.2 150.0 20.4 0.3 32.3 37.3 154.1 33.1 75.0 113.3 121.7 94.9 31.9 223.2 0.0 0.3 71.5 109.9 139.7 301.2 23.6 180.5 95.7 103.2 14.0 64.2 120.9 40.2 4.5 2.7 85.1 299.5 153.1 24.5 95.2 61.5 165.8 50.5 25.7 105.2 122.7 153.0 4.1 12.5 35.8 59.2 18.1 41.1 21.3 104.6 67.0 DMPK "DM, DM1, DM1PK, DMK, MDPK, MT-PK" ENSG00000104936 "DM1 protein kinase" Q09013 19 45769709-45782552 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" Cataract "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 44.1;Sertoli cells: 59.2;Smooth muscle cells: 34.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "RH-30: 85.1" "Low region specificity" "Detected in all" "Region enhanced" "Detected in many" "spinal cord: 8.7" "HPA007164, HPA008905" Enhanced Approved Vesicles,Cytosol NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 38: Heart - Muscle contraction" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 48: Smooth muscle cells - ECM organization" Cytosol Vesicles "HPA007164: AB_1078687, HPA008905: AB_1078685" "unprognostic (7.44e-2)" "unprognostic (2.66e-1)" "unprognostic (1.76e-3)" "unprognostic (2.61e-3)" "unprognostic (1.29e-1)" "unprognostic (5.46e-2)" "unprognostic (8.67e-2)" "unprognostic (1.50e-1)" "unprognostic (1.31e-1)" "unprognostic (1.67e-1)" "prognostic favorable (9.39e-5)" "unprognostic (1.93e-1)" "unprognostic (1.60e-2)" "unprognostic (1.19e-1)" "unprognostic (1.18e-1)" "unprognostic (3.03e-2)" "unprognostic (4.24e-3)" 24.2 68.3 22.1 17.5 24.0 3.0 19.1 22.2 33.1 42.8 25.6 121.5 15.8 92.7 5.3 33.4 61.2 13.9 171.3 21.8 21.6 20.3 8.8 29.8 5.2 24.0 23.8 31.1 34.3 2.9 37.9 8.8 22.3 56.4 4.8 4.1 18.6 37.6 173.6 12.3 34.6 59.9 21.9 17.8 51.7 13.2 23.8 4.2 21.7 143.2 1.3 69.1 34.3 21.3 11.7 16.7 13.5 10.7 13.4 12.9 10.5 26.1 22.2 10.5 8.8 2.2 6.6 2.9 2.8 32.9 9.2 15.1 3.0 1.5 2.2 12.4 16.6 0.8 22.6 1.4 12.6 0.1 5.4 22.8 8.0 6.4 1.7 24.2 3.6 2.1 8.6 8.0 15.4 13.7 1.6 3.8 8.8 4.8 3.3 5.0 85.1 6.4 4.7 11.5 10.2 13.5 13.6 27.6 9.3 4.8 28.6 5.5 8.4 9.2 10.4 8.3 15.0 16.8 11.5 2.9 9.5 1.3 13.1 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 22.1 24.0 22.2 33.1 21.8 21.6 24.0 23.8 22.3 21.9 23.8 21.3 10.5 0.0 2.2 44.1 3.7 8.0 8.1 3.8 5.7 5.7 9.6 9.9 3.7 4.3 3.2 3.7 8.4 2.7 4.2 4.7 1.9 2.7 1.5 8.7 8.6 7.9 10.1 0.4 16.4 17.3 2.0 8.4 8.2 6.3 0.0 9.7 9.3 1.5 0.8 5.0 12.4 8.2 8.2 1.6 9.8 1.8 7.2 0.8 7.2 10.3 0.4 2.6 5.2 26.7 10.0 5.8 4.5 23.3 3.1 4.0 3.8 31.7 7.1 7.4 59.2 27.6 34.9 7.2 6.4 10.1 6.8 1.6 4.5 5.4 5.1 4.6 DPH5 CGI-30 ENSG00000117543 "Diphthamide biosynthesis 5" Q9H2P9 1 100989623-101026088 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046439, HPA076234" Approved Approved "Nucleoli,Golgi apparatus" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 52: Non-specific - Ribosome" "Cluster 30: Epithelial cell lines - Translation" "Cluster 32: Non-specific - Translation" "Golgi apparatus" Nucleoli "HPA046439: AB_2679667, HPA076234: AB_2797274" "unprognostic (1.31e-1)" "unprognostic (3.37e-2)" "unprognostic (1.98e-2)" "unprognostic (7.82e-2)" "unprognostic (1.22e-2)" "unprognostic (2.23e-1)" "unprognostic (2.81e-2)" "unprognostic (3.57e-2)" "unprognostic (8.59e-2)" "unprognostic (8.12e-2)" "unprognostic (1.37e-2)" "unprognostic (2.56e-1)" "unprognostic (1.58e-2)" "unprognostic (2.15e-1)" "unprognostic (7.09e-2)" "unprognostic (1.88e-1)" "unprognostic (9.00e-2)" 12.5 23.2 17.2 8.4 17.8 10.7 28.8 17.3 22.5 23.2 18.3 14.6 7.1 17.2 23.8 13.7 26.2 11.6 23.5 17.4 18.7 19.5 25.3 10.1 18.1 17.8 18.0 49.8 31.4 20.0 15.5 12.3 17.8 15.0 17.5 8.8 11.9 17.1 20.8 15.0 11.2 19.7 17.6 15.4 14.1 9.8 19.0 29.0 20.7 25.0 25.4 14.7 13.3 18.0 28.1 30.1 40.1 37.0 48.3 154.7 34.9 24.9 42.9 41.0 34.5 35.3 7.7 46.0 33.2 22.2 23.1 20.0 47.5 41.1 62.6 20.0 35.8 22.1 26.7 71.4 84.1 33.4 13.8 97.1 63.9 38.8 118.6 67.4 64.8 33.4 62.6 16.7 70.3 26.3 40.7 36.7 31.5 15.2 46.4 37.8 51.1 32.6 50.0 25.7 44.2 22.2 13.7 36.2 114.0 29.6 27.3 18.3 25.1 23.0 28.7 28.8 34.4 20.0 24.1 31.9 31.5 29.6 7.9 5.7 7.5 4.6 16.1 8.9 21.7 19.2 17.9 17.7 13.6 15.1 24.0 20.9 2.7 24.7 10.6 9.8 12.8 10.2 17.2 17.8 17.3 22.5 17.4 18.7 17.8 18.0 17.8 17.6 19.0 18.0 8.1 6.4 14.6 17.0 30.3 15.8 17.0 24.2 19.9 5.3 18.7 12.3 23.8 21.5 12.7 7.3 0.0 26.2 10.1 4.7 23.5 14.0 1.8 14.2 19.6 11.2 10.2 17.7 12.0 18.4 27.8 13.5 5.6 8.2 25.4 29.0 12.1 29.3 18.9 1.7 14.6 15.0 22.4 28.4 13.1 3.0 27.1 14.0 12.4 8.4 27.7 16.5 27.8 27.2 28.3 8.9 12.9 13.9 10.3 10.8 8.1 30.9 16.8 6.5 6.6 16.6 12.5 15.7 17.6 17.0 18.0 13.0 19.4 33.4 23.7 11.3 DSTYK "DustyPK, KIAA0472, RIP5, RIPK5, SPG23" ENSG00000133059 "Dual serine/threonine and tyrosine protein kinase" Q6XUX3 1 205142505-205211702 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Horizontal cells: 89.2;Melanocytes: 90.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044140 Approved NA NA "Cluster 34: Basophils - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 62: Horizontal cells - Visual perception" "HPA044140: AB_10965031" "unprognostic (1.42e-2)" "unprognostic (1.07e-2)" "unprognostic (7.92e-2)" "unprognostic (1.02e-3)" "unprognostic (1.39e-1)" "unprognostic (2.66e-1)" "unprognostic (1.43e-2)" "unprognostic (9.01e-2)" "unprognostic (1.81e-1)" "unprognostic (1.06e-1)" "unprognostic (2.25e-3)" "unprognostic (1.20e-1)" "unprognostic (3.26e-2)" "unprognostic (7.80e-2)" "unprognostic (1.93e-1)" "unprognostic (1.55e-1)" "prognostic unfavorable (8.73e-5)" 4.5 7.2 11.5 3.8 11.1 19.2 6.7 11.5 12.1 6.4 6.8 6.0 2.7 7.9 5.8 5.5 7.2 4.5 4.9 11.8 11.3 7.5 2.2 6.1 4.0 13.5 10.7 11.1 4.5 13.1 5.5 6.0 13.7 5.6 3.6 13.5 4.4 6.9 9.6 12.0 4.1 7.1 9.9 6.2 4.2 5.1 11.5 6.2 6.8 6.8 4.5 5.2 5.4 13.5 9.9 6.3 6.6 8.1 9.5 15.9 4.7 12.0 12.1 12.4 8.4 2.9 5.3 7.3 3.5 20.6 6.9 6.9 7.3 7.8 12.4 3.5 7.8 13.3 8.1 3.1 8.5 3.7 6.8 9.4 11.6 12.7 12.0 14.7 9.2 5.2 17.4 4.8 10.0 6.8 2.9 3.3 7.2 1.8 7.4 2.6 12.1 6.5 8.4 6.1 3.7 7.2 10.3 10.5 34.5 7.7 7.8 4.9 9.2 7.7 7.7 11.8 8.2 4.8 3.7 4.1 9.0 5.1 28.2 8.1 1.9 3.6 2.4 1.5 2.3 1.5 1.8 2.0 1.7 1.7 2.6 1.9 2.7 2.8 1.0 1.2 1.1 1.0 11.5 11.1 11.5 12.1 11.8 11.3 13.5 10.7 13.7 9.9 11.5 13.5 15.8 28.9 15.5 26.4 15.3 14.9 7.2 10.5 14.2 48.0 14.5 13.6 13.6 12.8 15.1 16.5 33.3 6.8 15.1 3.8 5.9 12.5 11.3 16.3 37.7 16.1 12.7 31.6 35.1 9.1 6.1 19.4 8.2 11.6 24.1 43.2 28.5 6.9 8.8 89.2 36.6 6.2 6.1 23.6 15.6 25.2 16.4 11.4 90.7 21.5 20.6 45.1 23.7 17.1 43.0 10.6 5.0 18.0 11.1 10.7 6.1 6.9 24.7 37.3 26.3 22.4 16.4 22.3 13.0 10.1 13.9 2.6 15.1 27.8 7.5 6.7 DUSP1 "CL100, HVH1, MKP-1, PTPN10" ENSG00000120129 "Dual specificity phosphatase 1" P28562 5 172768096-172771195 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Stress response" "Hydrolase, Protein phosphatase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Langerhans cells: 2357.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 5 "neutrophil: 7426.8" "Lineage enriched" "Detected in all" 9 "granulocytes: 7426.8" "Cell line enhanced" "Detected in all" "HHSteC: 201.0;hTCEpi: 359.3;REH: 202.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA069577 Approved Nucleoli,Cytosol NA Yes "Cluster 50: Neutrophils - Cellular senescence" "Cluster 31: Skin - Epidermis development" "Cluster 30: Epithelial cell lines - Translation" "Cluster 41: Macrophages - Immune response" Nucleoli Cytosol "HPA069577: AB_2686156" "unprognostic (1.51e-1)" "unprognostic (1.24e-1)" "unprognostic (9.73e-2)" "unprognostic (8.17e-2)" "unprognostic (4.64e-1)" "unprognostic (1.58e-3)" "unprognostic (4.18e-2)" "unprognostic (6.94e-2)" "unprognostic (3.11e-1)" "unprognostic (1.43e-2)" "unprognostic (2.23e-1)" "unprognostic (1.51e-2)" "unprognostic (2.76e-2)" "prognostic unfavorable (3.11e-5)" "unprognostic (2.69e-1)" "unprognostic (2.35e-2)" "unprognostic (1.41e-3)" 922.6 515.4 84.9 364.9 85.8 692.4 586.1 134.8 121.1 501.3 134.7 336.1 66.0 382.3 42.0 526.6 677.4 570.5 395.3 79.4 114.6 281.2 721.3 719.9 178.6 132.0 90.3 541.2 240.1 116.5 319.5 297.3 104.1 438.5 228.5 202.7 350.3 356.9 251.8 1054.1 170.3 452.7 123.7 304.7 396.0 68.1 115.4 131.3 612.9 451.3 56.2 778.1 610.0 121.2 10.7 26.5 8.2 11.5 175.6 102.2 14.0 170.3 49.3 111.9 45.0 29.2 12.4 3.5 48.6 120.4 128.1 4.7 8.1 42.3 52.1 95.8 22.4 2.3 63.1 12.6 201.0 1.2 3.8 98.1 359.3 50.9 82.1 58.2 35.6 7.4 9.0 66.1 73.1 12.6 5.7 5.0 7.4 8.2 7.7 202.2 15.3 32.3 80.2 5.4 35.5 14.9 46.2 76.9 6.3 34.1 6.7 1.9 94.1 79.1 39.8 77.8 13.4 13.6 8.4 3.1 70.3 1.8 3.3 931.4 584.5 1640.7 85.0 589.2 212.6 57.6 75.6 88.6 263.4 54.1 35.9 40.7 7426.8 114.5 791.6 14.3 68.1 409.9 84.9 85.8 134.8 121.1 79.4 114.6 132.0 90.3 104.1 123.7 115.4 121.2 1856.5 410.3 341.0 23.8 918.4 1279.8 1140.5 456.9 1810.4 73.0 464.2 567.7 211.3 739.2 243.1 211.5 27.1 316.2 618.9 633.7 56.7 335.9 71.6 531.6 990.9 870.4 715.5 193.5 11.9 88.7 407.2 1367.4 597.3 1013.7 301.1 175.8 781.4 345.7 1043.0 48.8 13.4 891.8 207.5 1525.5 2357.3 40.3 384.9 1965.5 542.5 66.5 173.3 1159.3 33.0 6.6 4.1 226.3 683.3 311.1 952.2 685.7 736.1 35.5 218.0 190.5 769.2 720.7 671.9 12.9 24.6 1996.9 1956.6 582.0 1015.2 223.4 415.8 676.6 DUSP10 "MKP-5, MKP5" ENSG00000143507 "Dual specificity phosphatase 10" Q9Y6W6 1 221701424-221742089 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 32.9" "Cell type enhanced" "Detected in many" "granulocytes: 133.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "NK-cell: 19.7" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HaCaT: 102.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016758 Approved Supported "Nucleoplasm,Golgi apparatus,Cytosol" No No "Cluster 15: NK-cells - Transcription" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 24: Non-specific - Transcription regulation" Nucleoplasm "Golgi apparatus, Cytosol" "HPA016758: AB_1847880" "unprognostic (1.55e-1)" "unprognostic (2.73e-1)" "unprognostic (1.44e-1)" "unprognostic (6.65e-2)" "unprognostic (3.83e-2)" "unprognostic (2.85e-3)" "prognostic favorable (5.42e-4)" "unprognostic (2.89e-1)" "unprognostic (3.89e-2)" "unprognostic (9.68e-2)" "unprognostic (2.38e-2)" "unprognostic (1.05e-1)" "prognostic unfavorable (3.69e-4)" "unprognostic (4.18e-2)" "unprognostic (2.57e-1)" "unprognostic (8.88e-3)" "unprognostic (1.97e-2)" 3.8 2.4 4.3 5.2 7.4 25.0 6.0 7.7 5.3 4.5 4.7 8.0 1.4 3.6 1.2 6.0 6.4 6.6 2.6 4.5 4.5 1.4 32.9 6.2 9.1 7.1 6.0 1.6 17.0 1.2 1.2 3.8 5.8 2.7 4.1 14.9 6.3 0.9 22.9 6.1 3.9 8.9 3.8 6.1 2.5 3.1 9.0 5.6 4.4 3.6 7.6 6.1 2.7 13.5 15.2 6.4 0.5 0.4 45.4 22.6 0.5 10.1 25.9 16.2 12.5 0.3 4.2 11.6 3.3 26.1 11.9 102.3 2.2 9.8 14.0 30.5 1.2 20.4 3.0 1.8 10.6 9.1 13.3 31.9 7.0 17.6 17.8 7.5 0.6 3.0 2.1 4.0 16.0 0.3 1.8 7.2 1.5 3.2 0.7 1.1 28.5 0.9 5.7 9.1 37.4 3.0 1.3 1.2 43.6 5.6 2.1 5.5 3.6 8.1 2.2 12.6 12.4 6.8 5.1 6.2 12.8 4.1 8.9 8.2 5.5 0.3 4.5 4.6 3.9 0.8 2.9 3.1 7.0 0.9 1.0 1.7 0.5 19.7 1.9 0.2 16.9 2.2 4.3 7.4 7.7 5.3 4.5 4.5 7.1 6.0 5.8 3.8 9.0 13.5 4.9 0.0 1.7 2.6 21.7 50.9 13.5 13.6 25.6 6.0 42.4 18.7 4.7 14.3 19.2 3.7 20.9 2.8 39.0 3.1 0.0 35.9 61.1 57.9 6.6 6.7 43.9 2.5 0.3 9.1 3.7 7.9 4.6 53.7 133.5 0.2 1.8 53.6 22.3 1.7 30.9 17.7 69.2 9.7 46.9 7.1 24.8 26.0 23.2 2.8 14.1 14.3 17.5 17.1 50.5 26.2 0.8 12.8 9.9 11.0 0.4 1.1 18.5 34.2 0.0 33.7 5.3 9.7 3.2 16.7 41.3 3.4 47.0 28.7 3.6 16.5 DUSP11 PIR1 ENSG00000144048 "Dual specificity phosphatase 11" O75319 2 73762184-73780157 "Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase, RNA-binding" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021052 Supported "Nucleoplasm,Nucleoli fibrillar center,Cytokinetic bridge" Yes Yes "Cluster 31: Non-specific - Inflammatory response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 30: Epithelial cell lines - Translation" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Nucleoplasm, Nucleoli fibrillar center" "Cytokinetic bridge" "HPA021052: AB_2670577" "unprognostic (2.45e-3)" "unprognostic (1.06e-1)" "unprognostic (2.19e-2)" "unprognostic (7.87e-3)" "unprognostic (9.14e-2)" "unprognostic (5.28e-3)" "prognostic unfavorable (2.10e-7)" "unprognostic (7.20e-2)" "unprognostic (5.43e-2)" "unprognostic (5.85e-2)" "unprognostic (8.67e-3)" "unprognostic (3.84e-2)" "unprognostic (7.56e-3)" "unprognostic (1.41e-1)" "unprognostic (1.47e-1)" "unprognostic (1.47e-3)" "unprognostic (1.46e-1)" 16.0 13.3 7.9 17.1 7.7 35.2 20.4 13.4 11.2 22.4 7.6 16.0 17.3 21.2 19.3 30.5 39.0 15.9 14.2 8.1 6.9 20.2 17.9 14.3 25.3 6.1 5.7 23.5 11.0 14.7 14.0 20.5 6.1 16.5 17.4 8.3 16.0 14.4 14.3 27.6 15.3 19.6 4.8 19.0 16.3 16.8 6.5 24.8 16.5 17.8 26.1 25.2 22.4 8.3 39.4 16.7 17.6 18.6 31.2 38.7 31.2 28.2 36.7 35.8 36.4 24.2 29.1 50.6 17.7 30.6 32.1 26.7 22.0 56.8 34.3 35.2 22.9 31.2 12.0 37.3 32.7 35.5 28.0 31.6 67.3 32.1 44.1 31.1 40.4 24.2 33.6 28.6 40.2 21.3 34.3 37.6 28.4 36.7 22.7 13.6 47.3 46.0 29.3 32.1 25.9 14.1 26.1 30.6 35.7 21.0 16.4 18.6 23.1 25.4 31.4 29.5 33.7 30.7 26.2 68.1 23.5 35.5 25.3 72.5 42.2 99.5 56.3 39.3 73.5 68.3 65.8 67.4 47.3 65.9 69.4 65.5 65.2 69.8 40.6 35.7 88.6 71.7 7.9 7.7 13.4 11.2 8.1 6.9 6.1 5.7 6.1 4.8 6.5 8.3 26.5 9.6 12.0 7.5 39.5 83.2 55.1 93.0 39.3 11.0 12.9 15.1 8.6 27.1 45.7 12.9 4.2 32.8 34.8 15.5 50.9 29.6 9.1 18.0 15.7 34.6 12.0 21.0 14.9 27.3 42.0 26.5 16.3 13.6 40.7 20.5 52.1 15.3 30.7 5.0 12.7 18.0 36.7 20.2 27.1 7.0 28.9 17.0 23.2 10.3 34.8 9.8 41.2 13.0 13.8 28.2 17.8 25.6 31.8 30.0 22.8 50.4 38.2 16.6 6.6 18.2 23.1 23.8 34.6 42.8 83.0 38.6 39.8 20.7 18.8 60.9 DUSP12 "DUSP1, YVH1" ENSG00000081721 "Dual specificity phosphatase 12" Q9UNI6 1 161749758-161757238 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008840 Uncertain Supported Nucleoplasm NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA008840: AB_1847884" "unprognostic (3.51e-2)" "unprognostic (2.62e-1)" "unprognostic (1.05e-1)" "unprognostic (2.01e-2)" "unprognostic (2.11e-1)" "unprognostic (4.04e-2)" "prognostic unfavorable (1.99e-5)" "unprognostic (1.86e-1)" "unprognostic (1.06e-2)" "unprognostic (2.25e-3)" "unprognostic (9.52e-2)" "unprognostic (2.42e-3)" "prognostic unfavorable (1.55e-7)" "unprognostic (1.17e-1)" "unprognostic (1.84e-1)" "unprognostic (3.25e-2)" "unprognostic (2.42e-1)" 13.3 9.6 12.1 9.1 12.5 30.9 14.1 14.3 14.6 13.8 12.1 12.9 7.6 14.3 8.9 10.3 12.5 6.7 9.4 12.0 12.4 14.4 9.4 11.4 13.8 12.2 12.2 13.6 13.6 8.2 9.5 11.2 12.3 11.0 10.5 13.2 10.9 9.5 7.4 10.9 12.4 11.0 12.3 14.1 11.5 6.7 12.0 11.7 12.1 7.3 13.0 13.1 11.5 13.3 32.6 28.2 33.1 21.7 17.2 18.5 30.4 25.9 33.7 39.2 29.9 42.1 28.2 19.9 25.7 31.9 24.4 22.7 26.0 32.0 38.0 25.5 22.0 17.8 27.7 28.4 36.4 38.6 17.1 25.4 34.6 34.1 61.0 22.2 27.6 27.2 31.7 20.9 28.3 30.0 22.7 43.2 52.1 35.2 43.1 32.2 32.0 32.9 22.2 39.3 20.6 43.6 21.9 36.2 44.1 36.2 31.3 43.6 19.3 33.3 30.8 26.3 55.6 35.3 31.0 47.0 20.3 38.1 33.3 32.0 16.9 13.7 18.4 19.5 22.9 19.2 20.8 17.8 22.0 20.0 19.6 21.8 6.8 28.4 12.2 10.0 19.5 12.9 12.1 12.5 14.3 14.6 12.0 12.4 12.2 12.2 12.3 12.3 12.0 13.3 22.9 19.2 12.8 8.1 25.5 13.6 14.4 25.9 25.6 15.9 13.4 16.1 5.0 8.6 15.6 7.3 8.4 21.7 26.4 4.8 21.5 22.2 4.2 7.4 13.7 18.4 11.3 16.2 11.9 24.3 22.7 17.3 11.7 7.2 18.3 18.7 18.5 8.2 20.5 10.1 14.8 9.8 8.2 20.6 16.2 1.2 8.7 15.4 10.6 10.3 22.1 15.8 33.0 12.1 14.4 21.2 6.5 17.7 27.5 17.1 8.6 18.5 7.0 19.6 0.0 13.2 24.5 13.9 12.6 18.2 13.1 17.6 23.5 16.4 12.1 12.0 DUSP13 "BEDP, DUSP13A, DUSP13B, FLJ32450, TMDP" ENSG00000079393 "Dual specificity phosphatase 13" "Q6B8I1, Q9UII6" 10 75094432-75109221 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "skeletal muscle: 247.2;testis: 53.7;tongue: 122.5" "Cell type enriched" "Detected in some" 4 "Early spermatids: 428.1" "Cancer enhanced" "Detected in some" "head and neck cancer: 1.0" "Low region specificity" "Detected in single" "Immune cell enriched" "Detected in single" 10 "neutrophil: 1.0" "Lineage enriched" "Detected in single" 10 "granulocytes: 1.0" "Cell line enhanced" "Detected in some" "BEWO: 4.3;EFO-21: 5.0;Hep G2: 11.0;K-562: 4.3;LHCN-M2: 9.5;RH-30: 8.0" "Not detected" "Not detected" "Low region specificity" "Detected in all" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 34: Spermatids - Unknown function" "unprognostic (1.79e-1)" "unprognostic (2.39e-2)" "unprognostic (2.39e-1)" "unprognostic (7.07e-2)" "unprognostic (1.66e-3)" "unprognostic (2.47e-3)" "unprognostic (8.63e-2)" "unprognostic (1.97e-1)" "unprognostic (2.63e-2)" "unprognostic (1.27e-1)" "unprognostic (3.92e-1)" "unprognostic (2.22e-7)" "unprognostic (1.93e-2)" "unprognostic (1.54e-1)" "unprognostic (4.81e-1)" "unprognostic (2.09e-2)" 0.1 0.0 0.1 0.0 0.1 5.8 0.1 0.1 0.3 0.3 0.1 0.0 0.0 0.0 0.3 3.7 0.1 0.0 17.3 0.1 0.5 0.1 0.1 0.3 0.0 0.2 0.7 0.0 0.0 0.2 0.1 0.0 1.3 1.0 0.0 0.0 3.5 0.0 247.2 0.5 0.0 0.0 0.1 0.5 0.0 53.7 0.1 0.2 0.1 122.5 0.0 0.0 0.3 0.2 0.0 0.0 0.1 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.0 1.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 11.0 0.0 0.0 0.0 0.9 0.9 0.0 0.0 0.0 0.0 0.0 4.3 0.0 9.5 0.5 0.0 0.0 0.6 0.1 0.0 0.0 8.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.3 0.1 0.5 0.2 0.7 1.3 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.0 1.7 0.3 1.1 3.4 0.0 0.0 0.1 12.2 0.0 0.1 0.0 0.0 2.1 0.0 0.0 0.0 0.0 428.1 0.0 0.0 0.6 0.0 0.0 0.1 0.2 1.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 94.0 0.9 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.9 0.1 0.1 0.0 0.0 0.2 0.0 0.0 21.7 0.6 10.4 3.3 6.3 2.0 3.0 0.1 0.0 0.0 0.2 DUSP14 "MKP-L, MKP6" ENSG00000276023 "Dual specificity phosphatase 14" O95147 17 37489891-37513501 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skin 1: 44.1" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 179.7;Basal prostatic cells: 239.3;Cytotrophoblasts: 162.8;Endometrial ciliated cells: 146.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 1.6" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "HBF TERT88: 36.4;SuSa: 24.9;WM-115: 37.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019911 Approved Approved Nucleoplasm,Cytosol NA Yes 79000 "Cluster 33: Neutrophils - Chromatin organization" "Cluster 27: Brain & Skin - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Cytosol" "HPA019911: AB_1847888" "unprognostic (1.32e-1)" "unprognostic (3.06e-1)" "unprognostic (2.19e-2)" "unprognostic (1.57e-1)" "unprognostic (4.60e-1)" "unprognostic (3.22e-2)" "unprognostic (3.43e-3)" "unprognostic (2.02e-3)" "unprognostic (2.18e-1)" "unprognostic (2.59e-1)" "unprognostic (7.02e-3)" "unprognostic (3.81e-1)" "prognostic unfavorable (6.97e-9)" "unprognostic (7.93e-2)" "unprognostic (1.97e-1)" "unprognostic (1.73e-1)" "unprognostic (1.41e-3)" 15.3 14.2 10.9 1.3 11.2 0.3 12.4 11.2 17.0 12.8 10.9 10.3 0.0 9.5 5.5 17.4 7.5 1.2 14.1 11.0 10.9 8.7 15.2 8.6 0.4 11.9 11.1 5.6 6.6 1.0 14.5 0.9 10.6 6.4 1.0 9.9 13.1 0.3 11.0 44.1 5.5 0.8 10.4 2.8 7.6 13.7 10.8 4.4 23.1 4.4 2.7 7.2 17.1 10.7 2.6 0.2 4.9 2.1 0.1 0.6 2.1 10.4 7.8 14.3 15.6 1.2 17.9 0.2 0.9 7.6 0.2 2.8 0.2 6.1 36.4 0.2 0.7 0.0 1.6 6.2 1.5 0.5 3.0 8.5 5.5 4.8 2.5 10.2 0.3 0.2 0.6 3.1 11.4 0.4 9.7 1.7 0.3 3.8 0.0 2.5 0.6 2.5 17.5 2.4 1.9 0.3 0.5 17.6 4.1 24.9 0.8 3.9 1.4 10.8 5.8 0.1 5.8 0.1 0.3 0.1 0.1 0.0 37.5 1.1 0.0 0.7 0.1 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.7 1.6 0.0 0.2 0.0 0.0 0.2 10.9 11.2 11.2 17.0 11.0 10.9 11.9 11.1 10.6 10.4 10.8 10.7 15.0 6.4 5.4 2.9 8.3 179.7 239.3 74.8 129.1 6.8 42.6 46.0 15.0 4.3 39.6 7.3 8.4 162.8 16.6 0.3 29.4 34.8 36.4 146.9 18.5 21.7 2.4 11.4 12.0 15.1 82.1 30.2 3.1 85.3 87.0 10.6 14.6 15.7 19.7 15.2 5.3 1.2 36.7 2.8 34.8 52.5 13.7 5.9 62.2 4.7 25.3 16.1 15.5 3.0 3.3 74.8 2.9 6.0 9.9 64.9 0.1 16.9 61.3 24.5 0.0 13.2 45.2 26.0 33.4 44.0 92.6 67.9 18.2 26.3 1.1 67.0 DUSP15 "bA243J16.5, bA243J16.6, C20orf57, FLJ20645, VHY" ENSG00000149599 "Dual specificity phosphatase 15" Q9H1R2 20 31847637-31870747 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 4 "testis: 210.5" "Group enriched" "Detected in many" 4 "Distal tubular cells: 273.9;Early spermatids: 288.8;Late spermatids: 979.4" "Cancer enhanced" "Detected in many" "renal cancer: 6.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CACO-2: 4.8;REH: 16.0;SH-SY5Y: 4.3;SK-MEL-30: 4.0;U-2 OS: 3.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA076649 Enhanced Approved "Plasma membrane,Cytosol" NA NA "Cluster 43: Testis - Unknown function" "Cluster 14: REH - Unknown function" "Cluster 25: Spermatids - Spermatogenesis" "Plasma membrane, Cytosol" "HPA076649: AB_2686811" "unprognostic (3.84e-2)" "unprognostic (2.30e-1)" "unprognostic (2.28e-1)" "unprognostic (9.01e-3)" "unprognostic (3.88e-2)" "unprognostic (2.36e-1)" "unprognostic (1.47e-2)" "unprognostic (2.24e-2)" "unprognostic (1.43e-1)" "unprognostic (1.76e-1)" "unprognostic (1.48e-5)" "unprognostic (7.31e-2)" "prognostic favorable (5.40e-7)" "unprognostic (2.79e-2)" "unprognostic (1.93e-1)" "unprognostic (3.11e-3)" "unprognostic (2.55e-1)" 1.7 5.9 5.3 0.2 7.6 0.1 3.4 10.7 7.5 5.9 4.9 1.8 0.5 3.4 9.0 1.0 1.5 0.7 7.8 4.8 7.7 50.0 0.7 1.6 0.6 17.1 8.7 5.2 2.4 13.0 8.7 0.7 8.1 6.6 0.1 0.6 2.1 3.0 0.9 1.2 1.5 0.3 7.8 2.7 2.3 210.5 7.6 0.3 9.6 0.3 0.2 2.5 2.7 8.8 0.2 0.2 0.1 1.4 0.0 0.3 0.0 0.0 0.0 0.7 0.0 4.8 0.1 1.0 1.9 0.2 2.6 0.0 0.3 0.0 0.0 0.0 0.5 0.4 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.3 0.0 3.4 0.6 0.0 0.0 16.0 1.8 0.1 0.0 0.0 2.1 4.3 2.6 0.0 4.0 0.1 1.1 0.9 0.0 0.0 3.6 0.0 0.0 1.6 0.0 0.0 0.0 0.6 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.3 7.6 10.7 7.5 4.8 7.7 17.1 8.7 8.1 7.8 7.6 8.8 2.9 0.0 0.0 1.3 0.8 0.6 1.3 0.0 0.0 0.6 3.6 4.4 2.5 1.5 0.0 18.4 4.2 0.0 0.4 0.1 273.9 2.4 288.8 0.6 4.0 2.2 1.8 0.0 1.7 1.0 0.1 2.9 1.5 0.6 0.0 7.0 1.8 0.1 0.6 6.7 2.6 0.4 0.0 0.6 1.9 979.4 8.7 1.2 7.2 0.0 0.6 2.9 0.0 3.0 4.7 0.6 0.0 10.9 0.0 0.9 0.0 55.3 0.1 0.3 0.0 2.5 3.3 121.5 6.0 0.3 0.1 0.1 0.3 7.5 0.7 0.4 DUSP16 "KIAA1700, MKP-7, MKP7" ENSG00000111266 "Dual specificity phosphatase 16" Q9BY84 12 12473282-12562863 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Granulosa cells: 114.9;Oligodendrocytes: 196.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "T-reg: 3.9" "Lineage enriched" "Detected in single" 5 "T-cells: 3.9" "Cell line enhanced" "Detected in many" "NTERA-2: 37.7;RT4: 34.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA020326 Approved Supported Nucleoplasm NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 18: Non-specific - Mitochondria" "Cluster 5: NTERA-2 - Transcription" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "HPA020326: AB_1847890" "unprognostic (8.05e-2)" "unprognostic (9.47e-2)" "unprognostic (1.49e-3)" "unprognostic (4.14e-2)" "unprognostic (9.86e-2)" "prognostic favorable (1.01e-4)" "unprognostic (1.75e-2)" "unprognostic (3.52e-2)" "unprognostic (1.13e-2)" "unprognostic (2.11e-1)" "unprognostic (1.78e-1)" "unprognostic (2.82e-1)" "unprognostic (2.34e-3)" "unprognostic (6.35e-3)" "unprognostic (2.42e-1)" "unprognostic (1.46e-1)" "unprognostic (5.76e-2)" 9.3 47.8 4.9 7.8 8.3 3.6 15.0 7.7 5.3 12.2 6.3 11.3 13.6 11.3 6.2 12.7 10.5 8.0 7.2 4.8 6.0 7.6 33.3 12.0 6.4 7.3 8.1 10.7 18.8 8.0 12.9 5.5 6.2 19.7 10.9 7.5 14.6 3.4 11.3 11.1 13.1 4.9 5.4 6.8 13.2 7.1 6.7 15.2 8.8 4.7 9.0 10.7 17.0 11.8 4.5 6.5 7.6 4.2 2.8 3.3 13.6 2.6 5.8 6.4 9.1 18.1 8.6 0.4 1.4 2.9 11.3 2.9 14.1 2.4 8.6 14.4 7.0 0.7 6.8 19.2 5.4 1.3 3.0 2.8 6.7 5.1 16.3 6.8 5.0 7.3 4.0 11.8 0.4 8.6 1.7 0.9 37.7 11.1 1.9 2.0 2.6 8.6 3.6 34.3 12.3 11.5 10.6 13.6 6.7 28.2 5.5 2.2 4.5 2.9 8.3 1.8 2.9 8.3 10.6 1.5 3.8 2.9 4.0 0.0 0.0 0.0 0.5 0.0 2.3 0.0 1.6 0.7 0.1 0.0 0.5 0.3 0.8 0.0 0.0 0.0 3.9 0.3 4.9 8.3 7.7 5.3 4.8 6.0 7.3 8.1 6.2 5.4 6.7 11.8 9.6 28.9 55.5 30.3 3.3 2.8 14.9 1.5 3.4 4.8 23.8 13.1 11.5 20.0 9.7 3.7 2.1 10.5 5.6 35.7 0.0 14.3 1.3 15.1 10.2 9.2 49.6 0.0 19.5 24.6 4.1 9.9 11.7 19.9 23.5 114.9 7.5 34.2 5.3 6.7 24.8 10.0 2.0 9.4 1.9 2.3 5.9 5.7 5.4 38.4 2.9 36.8 0.0 56.3 196.3 20.9 25.3 6.8 4.3 34.3 25.4 5.2 10.4 4.8 0.0 11.1 10.3 3.0 5.8 6.2 1.8 30.1 27.9 9.9 18.7 24.5 DUSP18 DUSP20 ENSG00000167065 "Dual specificity phosphatase 18" Q8NEJ0 22 30652051-30667887 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 123.4;Late spermatids: 344.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034070, HPA051349" Uncertain Supported Nucleoplasm Yes No "Cluster 31: Non-specific - Inflammatory response" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "CAB034070: AB_2094867, HPA051349: AB_2681450" "unprognostic (1.11e-1)" "unprognostic (2.34e-2)" "unprognostic (3.49e-3)" "unprognostic (4.88e-3)" "unprognostic (1.88e-1)" "unprognostic (9.12e-2)" "unprognostic (3.77e-4)" "unprognostic (1.83e-1)" "unprognostic (1.61e-1)" "unprognostic (3.53e-2)" "unprognostic (9.62e-2)" "unprognostic (4.87e-2)" "unprognostic (1.23e-3)" "unprognostic (6.55e-2)" "unprognostic (1.97e-1)" "unprognostic (4.56e-2)" "unprognostic (1.02e-1)" 3.3 1.9 3.4 4.5 3.6 3.3 2.8 2.9 5.3 2.4 9.1 5.4 5.0 2.9 4.9 4.1 10.9 4.2 2.0 3.7 4.0 2.2 1.0 5.5 4.7 5.4 7.6 2.4 2.9 3.3 4.2 2.1 4.9 2.1 6.8 5.2 2.5 2.4 1.3 4.8 4.6 3.8 4.8 4.3 4.8 13.9 4.5 4.0 3.3 1.6 3.9 3.3 2.6 6.0 5.4 5.4 2.5 5.8 6.2 11.9 2.3 4.9 5.3 4.7 5.1 3.1 5.3 3.6 3.3 6.0 6.2 3.8 1.3 3.8 5.3 9.8 6.1 1.5 2.2 2.2 2.6 7.4 5.3 3.1 5.4 7.8 3.0 5.3 15.0 4.1 1.7 2.8 5.2 4.8 4.2 1.8 0.8 6.4 3.3 2.8 1.7 1.2 5.6 3.7 6.2 3.7 4.8 1.7 3.5 3.2 4.5 2.2 11.1 9.9 5.4 2.7 2.8 2.1 2.6 1.7 11.4 1.3 5.0 31.4 15.3 29.9 8.6 19.3 6.6 9.7 9.6 7.7 17.2 8.7 6.6 7.5 31.8 7.4 21.4 9.7 13.2 8.4 3.4 3.6 2.9 5.3 3.7 4.0 5.4 7.6 4.9 4.8 4.5 6.0 7.2 19.2 5.4 11.4 7.1 21.4 13.3 6.5 2.2 2.9 4.9 3.4 2.0 10.0 9.6 5.5 45.9 1.2 12.0 10.0 3.9 10.1 123.4 34.5 5.0 10.1 35.5 2.1 8.0 9.4 3.9 6.8 8.6 5.0 7.0 4.4 13.9 1.1 8.1 1.7 4.4 15.4 6.1 15.6 28.5 344.2 8.4 13.2 8.8 13.1 13.9 10.1 9.2 1.5 14.3 9.3 15.4 6.8 3.9 8.8 24.2 4.1 64.6 16.8 6.6 8.6 6.6 63.0 17.2 5.7 21.3 1.0 9.7 3.5 19.0 8.7 DUSP19 "DUSP17, SKRP1" ENSG00000162999 "Dual specificity phosphatase 19" Q8WTR2 2 183078559-183100008 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Early spermatids: 15.2;Endometrial ciliated cells: 17.7;Respiratory ciliated cells: 15.7;Spermatocytes: 15.5" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in many" 6 "amygdala: 1.3;basal ganglia: 2.4;cerebral cortex: 2.7;hippocampal formation: 3.8" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HEL: 7.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021501 Approved Approved Nucleoplasm Yes No "Cluster 35: T-regs - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 49: Ciliated cells - Cilium organization" Nucleoplasm "HPA021501: AB_1847892" "unprognostic (1.24e-1)" "unprognostic (2.13e-2)" "unprognostic (1.21e-1)" "unprognostic (1.64e-1)" "unprognostic (5.18e-2)" "unprognostic (2.44e-1)" "unprognostic (1.21e-1)" "unprognostic (1.88e-1)" "unprognostic (8.30e-2)" "unprognostic (1.49e-2)" "unprognostic (3.33e-2)" "unprognostic (6.53e-2)" "unprognostic (5.80e-3)" "unprognostic (6.97e-2)" "unprognostic (2.91e-2)" "unprognostic (2.16e-2)" "unprognostic (2.75e-2)" 1.1 1.4 1.3 0.8 2.4 0.3 1.1 0.0 2.7 1.2 0.1 1.4 1.4 1.4 3.5 1.4 3.2 1.3 3.1 3.8 0.1 1.8 1.1 1.3 1.0 0.1 0.0 1.6 0.9 1.6 1.2 1.0 0.0 1.5 1.0 1.2 0.9 1.9 1.6 1.3 1.1 1.9 0.0 1.6 3.9 3.7 0.0 1.2 1.7 1.7 0.7 1.1 0.6 0.4 0.1 1.6 1.8 0.9 2.5 1.4 0.0 0.7 1.1 2.9 1.0 1.5 1.9 0.6 3.8 0.8 2.1 0.2 3.8 0.5 2.3 3.9 1.8 7.1 1.1 1.0 1.0 1.8 4.2 1.1 0.3 1.3 0.7 1.8 1.5 0.0 2.2 1.0 1.8 0.6 3.4 1.6 1.5 0.6 1.2 3.3 2.9 0.2 0.6 0.7 2.3 0.9 2.6 1.1 2.0 0.1 0.5 0.6 1.3 1.6 1.3 1.1 0.6 1.3 1.6 0.0 2.0 0.3 2.4 0.7 0.1 0.6 0.6 0.2 0.6 1.1 0.5 0.8 0.1 0.5 0.7 0.7 0.3 0.7 0.1 0.4 1.0 0.3 1.3 2.4 0.0 2.7 3.8 0.1 0.1 0.0 0.0 0.0 0.0 0.4 2.5 0.0 3.2 0.7 1.6 1.0 1.3 1.1 3.4 1.8 2.1 2.7 8.3 1.5 1.8 1.8 2.1 2.0 0.8 1.5 5.9 0.9 15.2 17.7 2.3 3.3 2.4 0.0 9.9 0.7 1.5 1.7 3.6 1.5 1.3 3.0 2.9 1.9 0.6 1.7 7.8 1.9 0.0 0.8 0.3 6.0 1.8 2.2 0.0 1.0 1.1 4.8 2.1 4.0 3.1 0.6 3.4 2.6 0.3 0.7 2.2 2.9 15.7 1.5 0.0 1.9 4.4 15.5 3.8 2.3 1.6 0.7 1.2 3.6 1.8 1.1 DUSP2 PAC-1 ENSG00000158050 "Dual specificity phosphatase 2" Q05923 2 96143169-96145440 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 129.5" "Cell type enhanced" "Detected in many" "dendritic cells: 919.7;Glandular and luminal cells: 321.1;Langerhans cells: 924.0;Macrophages: 353.9;T-cells: 764.7" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in all" 4 "cerebral cortex: 55.0" "Immune cell enhanced" "Detected in all" "gdT-cell: 199.3" "Group enriched" "Detected in all" 10 "NK-cells: 148.1;T-cells: 199.3" "Cell line enhanced" "Detected in many" "Daudi: 30.4;HeLa: 29.7;JURKAT: 27.6;Karpas-707: 33.8;NB-4: 29.1;RT4: 34.2;SCLC-21H: 29.6;U-698: 43.2" "Low region specificity" "Detected in single" "Low region specificity" "Detected in some" HPA071920 Supported "Nucleoplasm,Nuclear membrane" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" "Nuclear membrane" Nucleoplasm "HPA071920: AB_2686472" "unprognostic (2.69e-3)" "unprognostic (6.70e-3)" "unprognostic (1.15e-1)" "unprognostic (5.46e-3)" "unprognostic (3.32e-2)" "unprognostic (8.54e-2)" "unprognostic (1.36e-1)" "unprognostic (1.15e-1)" "unprognostic (2.86e-1)" "unprognostic (3.66e-2)" "unprognostic (3.10e-1)" "unprognostic (6.30e-2)" "prognostic unfavorable (4.97e-5)" "unprognostic (1.82e-1)" "unprognostic (2.41e-1)" "unprognostic (3.94e-2)" "unprognostic (1.31e-3)" 17.0 6.0 7.6 18.6 11.6 129.5 5.5 7.5 55.0 8.1 9.2 4.5 1.6 7.0 7.7 6.8 7.6 12.5 19.5 13.4 6.2 12.7 7.5 18.2 47.1 8.0 6.3 7.8 2.3 1.7 35.1 1.3 6.7 17.6 2.0 0.4 3.9 61.5 2.8 26.0 11.8 3.4 6.7 42.0 7.4 3.6 6.9 47.3 6.7 3.7 24.6 39.5 9.0 9.3 3.2 0.0 0.2 0.2 0.4 0.5 4.4 3.7 0.0 5.3 5.1 8.9 0.6 30.4 10.6 4.1 0.0 2.2 7.5 0.0 1.0 0.5 0.0 0.7 29.7 0.0 1.9 12.8 2.6 0.9 2.0 0.9 0.0 0.1 0.0 27.6 0.0 33.8 0.2 5.2 25.5 29.1 6.5 0.8 10.6 0.0 0.4 24.3 0.2 34.2 29.6 1.5 1.4 0.3 5.6 0.0 2.0 14.4 0.1 0.0 7.9 0.0 1.7 2.3 3.9 43.2 0.0 13.9 0.3 2.3 4.3 1.0 199.3 10.5 95.4 17.5 46.7 176.2 10.7 13.9 32.0 99.3 6.1 148.1 9.1 3.0 16.1 40.5 7.6 11.6 7.5 55.0 13.4 6.2 8.0 6.3 6.7 6.7 6.9 9.3 50.8 0.0 7.7 0.7 303.7 96.7 155.0 31.3 70.6 27.8 65.8 72.0 37.8 2.8 12.0 9.2 22.9 0.9 919.7 20.4 1.9 0.9 0.9 115.6 62.7 28.7 87.8 50.5 5.2 1.4 1.7 22.8 86.6 321.1 104.3 7.4 12.8 3.9 80.2 0.0 1.4 37.5 8.2 40.4 924.0 1.4 1.8 353.9 144.1 1.9 3.4 1.5 90.6 1.0 0.5 1.0 2.5 1.9 268.5 70.4 1.6 1.4 2.7 3.6 0.0 14.7 26.6 0.6 4.8 50.4 109.7 1.6 764.7 3.0 51.6 41.1 DUSP21 ENSG00000189037 "Dual specificity phosphatase 21" Q9H596 X 44844021-44844888 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 41 "testis: 10.7" "Group enriched" "Detected in some" 99 "Early spermatids: 82.4;Late spermatids: 277.1" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 83: Testis - Spermatogenesis" "Cluster 31: Spermatids - Spermatogenesis" "unprognostic (5.17e-2)" 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 10.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 82.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 277.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 DUSP22 "JKAP, JSP1, MKPX, VHX" ENSG00000112679 "Dual specificity phosphatase 22" Q9NRW4 6 291630-351355 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RPMI-8226: 270.6;U-266/70: 130.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031394 Approved Approved Nucleoplasm,Vesicles NA NA "Cluster 37: B-cells - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 25: RPMI-8226 - Immune response" "Cluster 51: Myeloid cells - Hemostasis" "Nucleoplasm, Vesicles" "HPA031394: AB_10604114" "unprognostic (7.34e-3)" "unprognostic (7.94e-3)" "unprognostic (1.37e-2)" "unprognostic (1.14e-1)" "unprognostic (3.46e-1)" "unprognostic (1.70e-2)" "unprognostic (9.08e-3)" "unprognostic (2.48e-1)" "unprognostic (9.06e-2)" "unprognostic (5.56e-3)" "unprognostic (3.10e-2)" "unprognostic (3.04e-1)" "unprognostic (1.77e-1)" "unprognostic (3.97e-2)" "unprognostic (3.07e-1)" "unprognostic (2.35e-1)" "unprognostic (1.09e-1)" 36.9 16.4 25.6 27.7 29.1 23.7 33.0 27.4 28.8 31.6 21.2 47.8 22.5 28.9 12.2 45.7 25.9 21.3 42.1 25.1 27.1 32.4 32.7 38.5 32.4 32.3 28.5 19.6 40.8 13.2 21.2 27.3 30.3 23.2 16.1 7.8 30.4 15.1 52.3 41.4 33.7 22.0 28.0 43.9 32.7 44.9 29.3 15.0 28.1 37.7 30.5 30.3 36.8 42.7 13.7 8.3 17.3 25.9 19.5 21.5 22.8 9.9 8.0 8.6 10.3 8.8 15.1 28.4 23.3 10.3 18.3 9.4 21.9 18.3 6.1 68.6 25.1 19.3 7.1 24.7 9.9 7.0 24.4 16.2 54.1 6.2 11.3 14.1 24.8 24.0 18.3 92.2 7.2 8.2 10.3 25.1 10.4 10.0 18.7 20.2 11.7 270.6 16.2 5.8 29.7 11.6 8.5 3.4 29.6 37.4 17.6 8.9 34.2 7.7 10.1 7.8 6.0 130.0 98.6 40.0 3.0 19.0 17.7 36.4 32.5 13.6 8.6 26.5 6.2 40.4 6.7 9.1 33.5 33.3 6.1 8.8 21.8 5.9 25.1 28.8 15.9 19.6 25.6 29.1 27.4 28.8 25.1 27.1 32.3 28.5 30.3 28.0 29.3 42.7 45.5 16.0 21.3 5.5 53.7 26.5 22.0 33.3 14.2 5.7 19.4 17.5 40.8 10.0 30.7 5.5 0.0 10.8 51.1 11.7 21.5 24.2 13.4 18.6 8.2 33.4 9.5 8.2 8.5 51.4 7.7 21.9 15.3 12.9 33.0 8.8 21.8 25.0 30.1 0.0 6.1 14.7 32.6 38.6 43.0 20.5 15.5 47.1 46.2 21.5 78.4 14.9 36.0 7.1 25.9 29.2 12.4 9.4 59.7 16.5 23.2 18.2 39.7 3.2 26.3 11.6 22.8 34.5 73.8 42.5 37.1 6.6 21.3 6.8 15.4 27.9 DUSP23 "DUSP25, FLJ20442" ENSG00000158716 "Dual specificity phosphatase 23" Q9BVJ7 1 159780932-159782543 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Exocrine glandular cells: 458.5;Proximal tubular cells: 800.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HSkMC: 142.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028211, HPA045792" Approved Supported Nucleoplasm NA NA 22000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 43: THP-1 - Innate immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "HPA028211: AB_2672522, HPA045792: AB_10961133" "unprognostic (1.52e-1)" "unprognostic (4.12e-1)" "unprognostic (1.40e-3)" "unprognostic (3.33e-2)" "unprognostic (4.36e-2)" "unprognostic (3.22e-1)" "prognostic unfavorable (3.06e-4)" "unprognostic (3.16e-1)" "unprognostic (4.62e-1)" "unprognostic (3.33e-3)" "unprognostic (4.72e-2)" "unprognostic (3.75e-2)" "prognostic unfavorable (2.59e-5)" "unprognostic (8.58e-2)" "unprognostic (2.84e-2)" "unprognostic (7.47e-2)" "unprognostic (1.39e-1)" 75.0 122.4 29.1 15.4 31.5 20.5 99.9 32.0 38.5 57.6 30.0 46.3 26.7 55.0 15.5 82.0 52.3 13.4 36.1 31.8 31.4 199.1 189.3 55.3 10.4 32.0 30.1 35.6 76.8 34.6 20.8 5.9 32.1 55.3 13.9 8.1 152.4 15.3 65.4 61.1 42.9 12.0 32.8 39.2 39.7 18.2 31.3 15.2 58.8 16.6 9.1 45.1 53.6 31.0 39.5 42.2 0.3 0.2 39.5 33.5 0.4 15.8 13.0 18.4 14.3 17.3 44.7 0.1 90.9 17.6 4.2 1.5 10.8 14.5 10.0 9.9 4.6 54.4 14.7 0.0 58.6 33.3 40.4 142.8 38.3 12.1 43.0 13.2 71.0 0.1 25.2 19.4 26.3 72.5 3.5 1.4 71.3 71.6 58.7 0.1 0.0 18.8 22.7 6.9 17.8 39.4 28.6 63.0 78.5 7.3 40.6 51.7 51.7 15.3 0.8 1.9 0.2 13.5 34.8 0.5 25.8 26.5 11.7 111.8 181.7 229.1 97.9 153.4 54.6 60.5 72.7 92.8 261.3 43.7 44.0 65.1 185.6 100.5 105.6 59.2 70.8 112.2 29.1 31.5 32.0 38.5 31.8 31.4 32.0 30.1 32.1 32.8 31.3 31.0 100.4 41.7 58.7 3.3 23.8 74.6 129.2 151.8 100.7 8.5 110.6 112.1 29.5 95.8 122.2 51.5 6.2 16.1 28.4 97.7 262.2 210.7 48.3 47.5 30.8 155.8 35.4 37.5 1.4 458.5 29.2 31.2 32.1 130.9 54.5 66.1 75.0 249.4 170.3 1.7 0.5 124.9 91.6 94.3 72.9 8.4 26.4 92.2 42.7 4.7 58.9 74.8 69.0 1.0 4.4 208.4 112.2 15.8 14.6 121.5 140.4 800.7 54.8 10.0 13.1 16.0 34.9 5.4 19.9 123.2 74.4 5.7 43.6 72.3 109.5 116.1 DUSP26 "DUSP24, MGC1136, NEAP" ENSG00000133878 "Dual specificity phosphatase 26" Q9BV47 8 33591330-33600023 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "skeletal muscle: 421.3;tongue: 204.4" "Cell type enhanced" "Detected in some" "Bipolar cells: 76.8;Cardiomyocytes: 59.4;Cone photoreceptor cells: 41.7;Enteroendocrine cells: 25.7;Horizontal cells: 25.2;Rod photoreceptor cells: 75.2" "Cancer enhanced" "Detected in some" "glioma: 6.7;pancreatic cancer: 4.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "SCLC-21H: 97.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA018221 Approved Supported Nucleoplasm NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 80: Striated muscle - Unknown function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 56: Bipolar cells - Visual perception" Nucleoplasm "HPA018221: AB_2669813" "unprognostic (2.77e-4)" "unprognostic (2.70e-2)" "unprognostic (2.70e-3)" "unprognostic (5.47e-3)" "unprognostic (2.01e-1)" "unprognostic (1.24e-1)" "unprognostic (1.62e-1)" "unprognostic (2.53e-2)" "unprognostic (2.81e-1)" "unprognostic (1.39e-1)" "unprognostic (4.10e-3)" "unprognostic (1.78e-2)" "unprognostic (2.28e-1)" "unprognostic (1.52e-2)" "unprognostic (1.14e-1)" "unprognostic (8.15e-2)" "unprognostic (5.80e-2)" 0.7 27.4 44.2 1.2 45.2 0.2 0.4 47.4 49.6 1.2 18.4 2.8 3.5 1.3 5.6 5.0 3.6 1.2 70.8 45.0 53.0 1.5 0.2 3.3 0.4 39.8 42.1 33.2 3.0 2.0 61.4 0.0 55.2 4.2 1.1 34.1 4.6 0.8 421.3 0.3 2.6 2.7 38.3 0.7 3.9 3.6 44.4 0.8 0.9 204.4 0.8 1.2 1.7 41.1 0.0 0.0 0.4 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.3 0.1 0.1 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 1.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 97.7 23.1 0.0 0.1 0.0 0.0 1.1 0.0 0.0 0.0 0.2 0.1 0.1 3.1 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 44.2 45.2 47.4 49.6 45.0 53.0 39.8 42.1 55.2 38.3 44.4 41.1 0.0 0.0 0.0 1.3 0.9 0.0 0.2 0.0 0.6 76.8 0.0 0.3 59.4 0.0 0.0 0.0 41.7 0.0 0.0 0.0 21.5 0.4 7.8 0.4 0.1 0.8 25.7 0.0 11.3 0.4 0.0 3.5 0.5 0.1 0.0 1.0 0.4 0.0 0.0 25.2 14.7 0.5 0.0 0.0 0.0 5.2 0.0 0.1 1.8 2.8 0.0 22.8 0.0 12.1 12.0 1.1 0.0 6.0 5.3 0.3 0.0 2.5 0.0 75.2 0.0 10.8 5.2 0.2 0.2 0.0 0.0 0.0 0.6 0.7 0.1 0.1 DUSP28 "DUSP26, VHP" ENSG00000188542 "Dual specificity phosphatase 28" Q4G0W2 2 240560054-240565256 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Late spermatids: 39.7;Spermatocytes: 45.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "basophil: 8.9" "Lineage enriched" "Detected in all" 5 "granulocytes: 8.9" "Cell line enhanced" "Detected in many" "U-266/70: 8.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA047456, CAB069448" Uncertain Uncertain "Nuclear speckles,Cytosol" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 29: U-266 - Adaptive immune response" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "Nuclear speckles" Cytosol "CAB069448: , HPA047456: AB_10961145" "unprognostic (1.88e-2)" "unprognostic (9.29e-2)" "unprognostic (4.86e-2)" "unprognostic (2.32e-1)" "unprognostic (1.65e-1)" "unprognostic (1.07e-2)" "unprognostic (1.09e-2)" "unprognostic (7.56e-3)" "unprognostic (4.13e-3)" "unprognostic (3.71e-2)" "prognostic favorable (1.84e-4)" "unprognostic (9.85e-2)" "unprognostic (1.80e-3)" "unprognostic (6.99e-2)" "unprognostic (2.52e-1)" "unprognostic (2.59e-1)" "unprognostic (2.10e-3)" 1.5 2.4 1.6 1.3 1.7 5.4 1.7 3.0 1.8 2.2 0.5 2.5 1.1 2.1 1.7 3.1 2.6 0.8 3.4 1.3 1.7 3.2 3.2 2.2 1.9 1.7 1.2 2.2 3.0 0.9 3.9 0.6 1.4 3.5 1.0 1.2 2.8 0.8 9.8 2.0 3.6 0.6 1.1 4.7 2.7 6.2 1.5 1.1 3.5 4.0 1.5 2.3 2.2 2.0 1.0 0.8 1.1 1.4 0.7 0.4 1.3 1.0 0.6 0.8 0.5 0.5 2.4 1.7 0.6 0.6 1.3 3.1 0.9 0.3 0.7 2.2 4.0 2.1 2.2 1.3 0.5 1.6 3.7 1.0 0.9 0.6 0.6 1.6 0.4 2.3 1.6 1.9 0.7 1.1 1.7 2.5 0.9 1.4 0.9 2.3 2.4 2.1 0.6 1.6 2.8 1.5 0.9 1.1 1.3 0.7 1.2 2.2 1.0 1.9 1.6 1.3 1.0 8.2 2.1 2.8 1.2 1.0 1.5 8.9 1.1 0.5 1.2 0.7 1.4 1.0 1.2 1.3 0.6 1.8 1.4 1.2 1.9 1.5 0.7 1.9 0.9 0.9 1.6 1.7 3.0 1.8 1.3 1.7 1.7 1.2 1.4 1.1 1.5 2.0 5.7 0.0 4.5 1.3 11.4 3.7 7.7 4.7 6.2 6.7 12.3 10.0 13.8 10.0 3.8 12.9 4.2 7.8 18.4 11.0 15.6 5.1 35.2 11.2 5.5 4.1 8.4 8.8 3.8 5.8 4.8 4.3 14.8 10.2 7.0 6.2 3.3 8.6 11.5 8.4 4.9 9.8 6.1 10.0 6.1 39.7 3.1 13.6 7.2 1.9 10.5 9.9 23.7 2.5 3.6 4.4 10.4 1.5 16.8 8.0 15.7 15.6 11.7 6.8 6.6 4.1 7.2 45.8 18.7 10.7 5.4 7.0 14.9 7.6 11.2 8.7 DUSP29 "DUPD1, DUSP27" ENSG00000188716 "Dual specificity phosphatase 29" Q68J44 10 75037836-75058514 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "skeletal muscle: 71.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA042964 Uncertain NA NA "Cluster 33: Striated muscle - Muscle contraction" "HPA042964: AB_10795764" "unprognostic (1.05e-2)" "unprognostic (1.77e-1)" "unprognostic (2.34e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.5 0.0 0.0 0.9 0.0 71.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 DUSP3 VHR ENSG00000108861 "Dual specificity phosphatase 3" P51452 17 43766125-43778977 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 261.9" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 274.3;Late spermatids: 160.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 9 "dendritic cells: 33.5;granulocytes: 11.0;monocytes: 29.3" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063616 Supported Nucleoplasm,Cytosol NA NA 1300000 "Cluster 14: Monocytes - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm Cytosol "HPA063616: AB_2685061" "unprognostic (1.52e-1)" "unprognostic (3.18e-2)" "unprognostic (1.10e-1)" "unprognostic (8.54e-2)" "unprognostic (1.04e-3)" "prognostic unfavorable (3.00e-4)" "unprognostic (4.83e-2)" "unprognostic (8.98e-2)" "unprognostic (5.13e-1)" "unprognostic (6.01e-2)" "unprognostic (1.78e-1)" "unprognostic (8.40e-3)" "prognostic favorable (5.49e-5)" "unprognostic (2.67e-3)" "unprognostic (5.45e-2)" "unprognostic (1.94e-1)" "unprognostic (1.37e-2)" 39.8 43.2 63.6 21.6 67.1 9.9 32.7 57.2 91.0 32.4 59.6 96.1 27.8 49.2 31.1 48.4 33.6 33.4 194.8 69.0 65.4 72.0 108.1 50.2 14.3 64.2 64.3 18.2 48.6 47.0 33.1 31.4 64.4 57.7 26.0 30.8 31.8 72.9 261.9 24.6 38.7 62.9 58.5 40.7 57.5 24.5 65.6 6.2 30.5 213.7 13.0 63.1 33.6 64.3 32.3 57.1 21.5 23.1 61.1 32.7 18.3 23.8 56.4 54.4 65.1 55.4 21.1 4.9 36.7 44.7 112.4 27.3 33.7 29.3 56.9 11.1 25.6 16.2 25.9 45.4 74.5 2.0 16.1 30.5 51.5 42.0 36.2 59.0 38.5 15.9 14.7 5.4 64.2 23.1 8.5 8.4 9.9 45.5 41.1 10.5 64.5 12.1 75.8 33.3 12.0 21.6 27.9 18.3 71.8 58.8 82.2 44.7 40.4 61.1 41.5 87.9 40.1 28.5 40.4 1.2 72.4 22.6 20.8 11.0 29.3 6.4 1.5 15.0 2.7 2.6 2.4 1.9 33.5 2.4 1.9 1.7 7.0 1.7 20.6 13.8 1.6 11.4 63.6 67.1 57.2 91.0 69.0 65.4 64.2 64.3 64.4 58.5 65.6 64.3 23.1 25.6 21.2 6.5 9.2 22.4 47.6 17.6 10.8 17.2 20.3 21.3 274.3 54.3 17.9 42.3 25.0 16.3 9.5 36.9 41.1 47.8 88.6 18.8 16.6 33.8 36.4 11.6 18.1 58.9 21.8 25.9 42.8 25.0 38.7 6.1 25.4 108.8 86.6 20.2 15.5 19.9 24.4 49.1 52.0 160.5 14.6 47.2 10.6 15.9 53.9 16.8 4.1 8.5 13.8 56.5 32.3 26.4 8.0 46.2 57.7 87.6 21.1 17.3 32.9 24.1 28.4 3.3 5.0 16.0 28.8 45.0 6.3 15.1 18.0 42.6 DUSP4 "HVH2, MKP-2, TYP" ENSG00000120875 "Dual specificity phosphatase 4" Q13115 8 29333064-29350684 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pancreas: 32.2;stomach 1: 32.4" "Cell type enhanced" "Detected in many" "Glandular and luminal cells: 155.5;Ionocytes: 126.1;Pancreatic endocrine cells: 195.2" "Cancer enhanced" "Detected in all" "melanoma: 42.9" "Region enhanced" "Detected in many" "hippocampal formation: 20.9" "Immune cell enriched" "Detected in single" 9 "T-reg: 6.7" "Lineage enriched" "Detected in single" 20 "T-cells: 6.7" "Cell line enhanced" "Detected in many" "A549: 100.0;OE19: 91.7;SK-MEL-30: 157.2;WM-115: 122.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA061967 Supported Nucleoplasm NA NA "Cluster 35: T-regs - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 17: WM-115 - Nervous system development" "Cluster 41: Macrophages - Immune response" Nucleoplasm "HPA061967: AB_2684648" "unprognostic (1.92e-1)" "unprognostic (5.97e-3)" "unprognostic (3.24e-1)" "unprognostic (6.54e-2)" "unprognostic (2.18e-2)" "unprognostic (7.66e-3)" "unprognostic (7.30e-2)" "unprognostic (7.08e-2)" "unprognostic (1.83e-2)" "unprognostic (9.73e-3)" "unprognostic (9.60e-3)" "unprognostic (3.15e-2)" "prognostic unfavorable (4.19e-4)" "unprognostic (6.88e-2)" "unprognostic (1.62e-1)" "unprognostic (1.08e-2)" "unprognostic (6.07e-2)" 15.2 5.2 2.3 5.4 1.4 6.2 23.7 5.0 9.0 6.0 0.4 1.2 1.2 4.5 0.1 2.5 1.9 11.3 2.3 20.9 1.2 2.8 0.7 5.7 2.6 1.6 1.1 0.4 32.2 0.6 5.3 7.5 1.1 5.2 1.4 5.9 16.1 10.1 4.2 5.6 2.0 1.2 0.3 1.0 32.4 2.8 2.9 4.2 1.2 0.9 2.7 13.8 2.8 1.1 38.0 100.0 57.9 2.8 7.2 0.0 4.9 7.7 42.0 22.8 10.1 1.1 18.8 0.0 20.5 3.6 16.0 12.0 0.7 25.7 13.5 1.0 1.9 0.3 3.7 0.7 0.2 0.5 47.3 4.6 16.7 7.1 42.1 49.7 18.9 0.4 0.3 4.5 46.0 42.9 0.1 7.1 10.1 91.7 60.5 1.2 1.9 8.1 52.3 19.7 0.4 32.0 10.8 49.5 157.2 1.1 10.7 1.1 53.3 16.7 0.3 0.0 5.7 11.6 1.4 0.1 50.2 8.9 122.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 6.7 0.0 2.3 1.4 5.0 9.0 20.9 1.2 1.6 1.1 1.1 0.3 2.9 1.1 11.1 0.0 2.8 0.0 33.5 12.1 98.3 27.3 4.0 43.2 80.4 62.2 2.6 51.5 51.1 0.0 12.5 3.2 24.0 1.9 0.0 74.3 7.6 64.7 13.3 16.3 97.8 0.0 3.8 78.6 40.9 9.6 121.8 155.5 6.3 0.0 21.8 0.3 25.0 43.7 8.2 8.5 126.1 4.0 102.8 25.6 0.3 47.4 65.8 0.0 75.6 0.8 0.0 1.5 0.3 195.2 0.0 0.0 31.0 30.9 0.4 0.2 43.6 3.4 13.1 18.9 17.8 1.4 8.2 2.3 11.9 17.8 115.6 0.1 4.6 102.7 DUSP5 HVH3 ENSG00000138166 "Dual specificity phosphatase 5" Q16690 10 110497907-110511533 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "urinary bladder: 175.7" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 409.1;Langerhans cells: 298.4;Plasma cells: 412.2;Urothelial cells: 1063.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "non-classical monocyte: 10.3;plasmacytoid DC: 14.5" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "hTERT-HME1: 408.0;Karpas-707: 161.2;U-266/70: 227.8" "Region enhanced" "Detected in all" "cerebellum: 60.7" "Region enriched" "Detected in many" 5 "cerebellum: 45.4" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 22: Epithelial cell types - Mixed function" "unprognostic (1.25e-1)" "unprognostic (3.57e-1)" "unprognostic (5.19e-2)" "unprognostic (1.03e-1)" "unprognostic (1.76e-2)" "unprognostic (3.27e-3)" "unprognostic (6.35e-2)" "prognostic unfavorable (8.30e-6)" "unprognostic (1.70e-2)" "unprognostic (4.60e-2)" "unprognostic (2.91e-2)" "unprognostic (1.20e-2)" "unprognostic (4.20e-3)" "unprognostic (3.79e-1)" "unprognostic (3.78e-3)" "unprognostic (2.32e-1)" "unprognostic (9.09e-2)" 38.8 37.6 8.5 26.8 8.6 38.5 26.6 26.1 17.3 39.4 13.3 22.3 12.2 19.7 2.0 115.5 12.7 51.4 34.1 17.9 12.4 26.4 25.6 23.2 12.8 7.7 9.3 7.6 8.0 6.7 20.0 48.3 7.4 17.7 26.3 9.8 23.4 12.5 2.7 16.9 19.5 21.1 8.3 28.4 26.5 20.1 10.7 14.9 18.8 3.7 32.5 175.7 37.9 7.9 22.0 14.6 3.0 7.3 11.1 46.5 10.6 50.9 114.6 26.8 32.2 9.4 28.9 2.6 9.4 12.4 56.9 7.0 2.8 26.7 43.2 62.8 1.8 12.1 2.6 5.8 41.8 3.2 15.1 17.9 35.9 85.7 408.0 11.8 17.1 1.2 2.1 161.2 81.4 5.9 0.9 9.2 9.6 2.1 22.2 0.2 6.3 38.8 92.0 42.3 1.6 4.0 3.3 8.0 17.4 25.6 4.5 3.8 26.5 9.0 6.2 21.7 24.7 227.8 44.7 6.2 34.9 16.4 6.4 0.5 0.2 0.0 3.5 2.2 1.3 0.2 1.8 1.0 0.9 0.0 0.1 1.0 0.2 0.0 10.3 14.5 0.1 0.6 8.5 8.6 26.1 17.3 17.9 12.4 7.7 9.3 7.4 8.3 10.7 7.9 150.7 3.2 7.8 0.3 71.2 66.0 409.1 91.4 30.7 9.0 72.7 77.0 33.5 11.5 78.3 35.0 6.2 44.0 97.7 63.5 5.9 29.1 1.5 50.6 32.2 90.8 48.9 0.4 4.4 4.8 11.2 42.7 39.3 196.6 3.8 5.5 158.5 4.1 10.7 0.0 2.2 12.8 22.4 16.6 298.4 3.3 1.5 91.5 158.3 1.0 46.9 2.3 4.1 1.0 0.0 49.1 93.2 0.7 412.2 127.0 44.4 0.6 27.3 12.6 0.0 25.8 37.3 1.2 19.8 61.8 101.9 137.4 122.0 3.3 9.2 1063.2 DUSP6 "MKP-3, PYST1" ENSG00000139318 "Dual specificity phosphatase 6" Q16828 12 89347235-89352501 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Disease variant, Hypogonadotropic hypogonadism, Kallmann syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "salivary gland: 226.2" "Cell type enhanced" "Detected in all" "Alveolar cells type 2: 246.8;granulocytes: 456.9;Kupffer cells: 266.7" "Cancer enhanced" "Detected in all" "thyroid cancer: 97.6" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 1636.7" "Group enriched" "Detected in all" 13 "granulocytes: 1636.7;monocytes: 842.3" "Cell line enhanced" "Detected in many" "AN3-CA: 427.6;NB-4: 325.8;SK-MEL-30: 253.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017566, HPA053188, HPA064692" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 17: WM-115 - Nervous system development" "Cluster 60: Granulocytes - Receptor signaling" "Nucleoplasm, Cytosol" "CAB017566: AB_647991, HPA053188: , HPA064692: " "unprognostic (7.35e-2)" "unprognostic (1.50e-2)" "unprognostic (5.77e-2)" "prognostic favorable (7.21e-4)" "unprognostic (2.35e-3)" "unprognostic (2.10e-3)" "unprognostic (3.76e-2)" "unprognostic (1.42e-1)" "unprognostic (8.63e-2)" "unprognostic (1.67e-2)" "unprognostic (3.15e-3)" "unprognostic (2.09e-1)" "unprognostic (5.91e-3)" "unprognostic (1.28e-2)" "unprognostic (3.95e-2)" "unprognostic (1.86e-2)" "unprognostic (2.84e-1)" 113.9 24.7 12.0 63.7 12.9 178.7 50.8 10.0 28.5 39.4 29.8 47.3 24.8 26.2 14.2 34.8 36.6 75.5 30.9 19.8 11.6 58.9 143.3 88.2 42.3 12.6 12.1 14.2 17.9 34.6 17.8 74.1 12.4 18.8 56.1 6.8 226.2 22.9 8.5 17.4 52.1 43.2 12.7 71.0 28.7 6.9 16.0 47.7 77.4 40.2 27.2 76.4 13.8 13.6 6.4 6.2 127.0 427.6 108.1 89.9 0.2 47.5 58.3 9.5 6.8 38.7 6.8 0.0 11.2 20.5 17.9 51.4 0.5 118.4 13.0 0.5 0.8 20.0 1.4 61.4 75.7 86.3 210.9 18.4 40.4 81.5 75.5 94.9 214.4 2.6 0.0 20.4 29.3 3.1 2.9 325.8 78.7 149.5 102.7 216.6 15.5 8.3 129.3 129.7 2.4 88.7 1.1 0.6 253.0 43.3 6.4 46.8 59.0 30.6 0.8 5.8 22.8 3.7 18.5 0.5 126.5 60.0 200.3 1636.7 558.9 247.2 9.8 842.3 4.5 2.7 2.7 3.5 97.0 11.6 1.6 3.2 230.5 14.8 841.0 12.2 6.7 455.2 12.0 12.9 10.0 28.5 19.8 11.6 12.6 12.1 12.4 12.7 16.0 13.6 182.9 102.5 246.8 12.4 18.0 90.9 79.4 97.4 38.7 2.1 30.3 85.5 11.1 81.5 80.5 180.3 33.3 72.6 36.1 58.3 17.6 12.6 1.6 67.4 14.1 159.8 19.2 6.6 19.6 14.0 4.2 54.5 19.4 134.2 456.9 24.2 177.8 130.2 49.6 1.7 3.8 13.2 46.8 266.7 61.2 1.7 1.5 193.2 12.4 33.7 198.9 8.7 20.6 24.6 2.4 17.1 45.7 3.4 16.2 26.1 17.0 27.5 21.2 2.4 26.3 21.4 29.7 2.6 7.0 14.7 24.7 49.3 42.3 3.5 22.0 61.4 DUSP7 "MKP-X, PYST2" ENSG00000164086 "Dual specificity phosphatase 7" Q16829 3 52048919-52056571 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 117.3;Squamous epithelial cells: 51.6;Suprabasal keratinocytes: 135.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "hTCEpi: 109.8;hTERT-HME1: 92.6" "Low region specificity" "Detected in all" HPA073007 Approved NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 27: Brain & Skin - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 28: Keratinocytes - Keratinization" "HPA073007: " "unprognostic (1.19e-1)" "unprognostic (1.89e-1)" "unprognostic (1.66e-1)" "unprognostic (1.04e-1)" "unprognostic (1.88e-1)" "unprognostic (6.16e-3)" "unprognostic (2.32e-2)" "unprognostic (2.75e-1)" "unprognostic (1.44e-1)" "unprognostic (8.67e-3)" "unprognostic (7.38e-3)" "unprognostic (7.74e-3)" "prognostic unfavorable (8.84e-6)" "unprognostic (4.86e-2)" "unprognostic (1.24e-1)" "unprognostic (2.29e-2)" "unprognostic (9.46e-2)" 13.1 10.0 23.3 7.6 28.4 3.6 11.5 19.5 27.5 27.0 7.5 8.4 4.1 14.6 3.9 64.1 10.1 8.7 22.2 24.2 21.2 10.6 5.2 24.9 10.2 25.8 27.2 8.7 7.0 6.2 7.2 14.1 22.3 11.5 3.8 2.6 13.2 7.9 23.1 65.6 7.9 6.7 19.5 26.2 9.1 12.0 27.2 8.1 9.1 20.5 10.8 13.5 45.5 38.4 21.3 4.4 5.2 11.9 16.4 14.1 6.2 21.0 39.8 20.4 14.7 5.8 10.6 5.8 5.7 31.3 10.3 24.6 19.8 76.0 13.8 5.0 8.1 27.8 10.9 10.3 13.3 25.1 16.2 14.8 109.8 26.5 92.6 14.1 19.8 16.8 16.2 16.4 16.5 5.9 18.7 35.2 12.9 5.9 37.6 15.5 4.5 15.6 8.5 9.1 6.5 19.0 9.4 8.5 14.9 4.2 3.0 59.4 26.0 39.1 25.3 41.7 65.4 7.9 7.9 9.3 21.7 41.5 12.7 0.9 3.4 1.7 5.3 10.3 7.2 0.9 6.3 3.8 4.7 0.5 4.5 4.1 1.3 2.5 10.3 7.1 4.5 1.7 23.3 28.4 19.5 27.5 24.2 21.2 25.8 27.2 22.3 19.5 27.2 38.4 17.0 9.6 1.1 0.0 2.9 117.3 31.5 13.5 21.1 4.9 6.6 7.2 18.9 0.0 5.2 0.0 0.0 0.6 13.4 1.6 1.9 3.1 1.7 2.9 8.1 18.7 2.4 1.7 5.5 2.6 4.3 7.8 0.5 2.8 0.0 1.3 23.6 0.9 8.1 0.0 4.4 2.5 0.0 16.7 12.0 0.5 8.7 9.0 21.4 5.6 10.3 0.9 9.2 5.5 20.2 12.1 1.3 4.9 1.6 17.5 0.6 1.3 1.5 1.0 26.3 3.3 8.6 3.5 5.5 51.6 135.2 1.2 7.3 4.1 3.4 29.3 DUSP8 "C11orf81, FLJ42958, HB5, HVH-5" ENSG00000184545 "Dual specificity phosphatase 8" Q13202 11 1554051-1572271 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pituitary gland: 25.5" "Cell type enhanced" "Detected in many" "Bipolar cells: 113.6;Distal enterocytes: 57.8;Glandular and luminal cells: 65.6;Horizontal cells: 90.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "MCF7: 2.5;SCLC-21H: 1.4;SH-SY5Y: 1.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA020071 Approved Approved Cytosol NA NA "Cluster 72: Non-specific - Transcription" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 56: Bipolar cells - Visual perception" Cytosol "HPA020071: AB_1847903" "unprognostic (2.29e-1)" "unprognostic (4.15e-2)" "unprognostic (1.96e-1)" "unprognostic (4.00e-2)" "unprognostic (1.35e-1)" "unprognostic (7.58e-3)" "unprognostic (6.08e-2)" "unprognostic (1.11e-1)" "unprognostic (1.44e-3)" "unprognostic (1.81e-1)" "unprognostic (4.04e-3)" "unprognostic (1.82e-1)" "prognostic favorable (2.75e-6)" "unprognostic (1.51e-1)" "unprognostic (1.57e-1)" "unprognostic (8.65e-2)" "unprognostic (6.30e-2)" 6.6 2.1 3.5 0.2 3.0 1.0 6.0 0.3 8.1 5.1 0.0 11.3 0.0 8.4 0.6 1.4 8.7 0.5 17.0 5.0 0.1 5.4 3.6 9.5 0.3 1.9 0.4 2.4 15.7 0.2 25.5 0.1 0.1 5.1 0.3 1.6 6.1 0.2 13.3 4.3 6.8 1.2 0.3 3.1 8.3 3.1 0.7 0.2 3.7 0.0 0.1 3.6 4.2 2.0 0.6 0.3 0.4 0.0 0.0 0.0 1.1 0.1 0.4 0.1 0.6 0.6 0.0 0.0 0.2 0.1 0.0 0.9 0.0 0.1 0.3 1.1 0.6 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.7 0.0 2.5 0.0 0.1 0.1 0.0 0.7 0.0 0.0 0.3 0.0 0.0 1.4 1.7 0.1 0.2 0.3 0.0 0.1 0.0 0.0 0.1 0.8 0.3 0.8 0.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.5 3.0 0.3 8.1 5.0 0.1 1.9 0.4 0.1 0.3 0.7 2.0 14.9 3.2 1.1 0.0 6.3 9.8 8.1 2.7 2.8 113.6 32.1 24.3 6.0 14.3 3.2 12.9 47.9 0.3 11.1 57.8 1.9 7.7 0.3 31.5 24.7 6.5 42.3 0.0 11.1 11.3 0.5 4.3 8.6 65.6 0.0 0.4 1.4 0.6 0.5 90.9 11.3 32.6 6.1 0.0 3.4 0.2 0.6 4.7 5.4 2.8 1.0 22.3 1.0 3.0 5.2 11.0 22.4 0.4 4.7 17.4 19.1 1.6 2.8 35.5 6.6 8.0 15.1 0.8 0.6 2.2 4.8 5.9 10.5 0.7 25.0 14.2 DUSP9 "MKP-4, MKP4" ENSG00000130829 "Dual specificity phosphatase 9" Q99956 X 153642492-153651326 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 15 "kidney: 56.9;placenta: 72.6" "Group enriched" "Detected in some" 14 "Cytotrophoblasts: 1171.5;Distal tubular cells: 727.8;Syncytiotrophoblasts: 1735.1" "Cancer enhanced" "Detected in many" "liver cancer: 10.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in many" 9 "Hep G2: 372.7" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA003336 Enhanced Approved "Endoplasmic reticulum" NA NA "Cluster 28: Placenta - Pregnancy" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 47: Cytotrophoblasts - Unknown function" "Endoplasmic reticulum" "HPA003336: AB_1078709" "unprognostic (4.64e-2)" "unprognostic (6.48e-2)" "unprognostic (4.87e-2)" "prognostic unfavorable (1.60e-4)" "unprognostic (1.52e-2)" "unprognostic (2.74e-3)" "unprognostic (9.36e-3)" "unprognostic (6.15e-2)" "unprognostic (2.81e-1)" "unprognostic (3.03e-1)" "unprognostic (1.29e-2)" "unprognostic (1.38e-2)" "unprognostic (2.68e-7)" "unprognostic (4.49e-2)" "unprognostic (2.08e-1)" "unprognostic (2.77e-2)" "unprognostic (5.52e-2)" 0.2 0.0 4.1 0.0 3.3 0.0 0.2 1.7 3.8 0.1 1.1 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.0 4.0 1.9 56.9 1.1 0.0 0.0 2.1 2.5 0.8 0.5 0.7 0.0 72.6 2.2 0.1 0.0 0.0 0.5 0.3 0.0 0.1 0.1 0.0 1.9 0.0 0.0 1.6 2.8 0.0 0.0 0.0 0.0 0.7 0.1 2.6 1.6 0.8 0.1 32.6 0.0 0.0 10.3 0.1 0.0 0.0 0.0 6.5 2.0 0.0 15.8 0.0 1.2 7.5 39.9 1.0 0.0 1.1 7.3 0.0 3.0 372.7 0.0 0.0 5.6 0.0 0.5 0.0 0.0 0.0 0.0 0.2 9.7 0.0 0.0 2.1 0.1 0.8 1.1 1.8 14.8 0.0 0.0 0.0 0.1 9.4 0.4 1.2 2.3 2.8 1.6 0.9 0.6 3.9 0.2 0.0 7.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.1 3.3 1.7 3.8 4.0 1.9 2.1 2.5 2.2 1.9 2.8 2.6 0.0 0.0 0.0 3.6 0.5 0.6 1.0 0.6 2.8 0.0 0.2 3.4 2.3 1.5 0.0 11.0 0.0 1171.5 0.0 0.0 727.8 0.1 0.0 0.1 0.1 3.1 0.0 0.0 0.7 0.0 84.0 6.1 0.0 0.0 0.0 3.8 0.0 0.9 84.2 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.1 0.0 0.4 0.0 0.8 0.0 3.2 0.4 0.0 0.0 0.0 0.4 0.8 8.9 0.2 0.0 1735.1 0.2 10.8 0.1 1.1 DYRK1A "DYRK, DYRK1, MNBH" ENSG00000157540 "Dual specificity tyrosine phosphorylation regulated kinase 1A" Q13627 21 37365573-37526358 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Host-virus interaction" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 156.7;Inhibitory neurons: 158.4;Microglial cells: 176.1;Oligodendrocyte precursor cells: 158.3;Oligodendrocytes: 157.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015323, HPA015810" Approved Approved "Nucleoli fibrillar center,Cytosol" NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 36: HEL - Hemostasis" "Cluster 44: Endometrium - Transcription" Cytosol "Nucleoli fibrillar center" "HPA015323: AB_1847922, HPA015810: AB_1847921" "unprognostic (2.71e-1)" "unprognostic (3.35e-2)" "unprognostic (1.27e-1)" "unprognostic (5.62e-2)" "unprognostic (4.17e-2)" "unprognostic (1.41e-1)" "unprognostic (1.67e-1)" "unprognostic (9.28e-2)" "unprognostic (1.02e-1)" "unprognostic (1.51e-1)" "unprognostic (9.95e-2)" "unprognostic (7.39e-2)" "unprognostic (9.09e-2)" "unprognostic (1.07e-1)" "unprognostic (2.92e-2)" "unprognostic (3.14e-1)" "unprognostic (1.40e-2)" 23.1 20.4 17.8 22.5 19.9 71.4 22.3 29.9 20.7 23.9 22.2 22.2 18.7 26.6 22.0 18.8 22.6 19.9 28.9 21.3 19.2 19.9 19.8 22.3 30.1 12.1 14.7 29.6 21.5 27.8 20.2 23.0 13.3 18.8 21.6 27.8 21.3 19.2 49.4 24.2 21.7 24.1 12.8 30.4 22.8 29.9 18.6 45.8 25.7 45.2 26.7 24.3 21.1 20.9 23.5 18.2 36.3 25.6 17.1 18.8 32.7 20.8 26.0 20.3 22.0 25.7 19.7 31.7 13.8 37.0 27.1 15.8 27.3 21.2 24.4 49.7 11.6 93.6 30.9 16.1 26.5 36.9 32.3 18.7 24.3 26.5 41.2 23.5 22.3 44.2 36.4 70.4 22.2 23.6 49.3 25.9 38.5 24.1 10.8 62.8 19.7 29.6 22.3 30.4 36.5 20.4 47.1 31.6 33.2 12.2 29.9 34.8 27.8 27.6 8.3 17.2 17.4 47.7 41.6 44.9 22.0 41.8 30.7 3.1 0.5 0.8 1.2 0.8 0.7 1.1 1.3 1.0 0.7 1.0 1.4 1.3 2.3 0.5 1.1 1.3 1.3 0.3 17.8 19.9 29.9 20.7 21.3 19.2 12.1 14.7 13.3 12.8 18.6 20.9 36.8 19.2 25.5 114.3 28.8 37.5 24.1 15.7 18.2 32.7 28.3 18.0 73.0 20.0 23.0 11.0 27.1 10.3 43.0 30.1 0.0 13.5 29.7 44.2 39.3 31.9 21.4 26.1 156.7 14.6 12.4 25.2 21.4 71.4 24.7 35.9 27.1 18.1 15.8 47.1 158.4 18.8 14.2 25.0 27.7 22.2 16.1 32.4 24.9 176.1 18.8 16.4 21.6 158.3 157.2 21.2 22.4 19.5 33.8 29.8 17.1 9.9 27.9 21.8 13.1 38.4 32.5 15.3 24.7 24.6 31.7 15.3 36.8 21.3 19.3 37.2 DYRK1B MIRK ENSG00000105204 "Dual specificity tyrosine phosphorylation regulated kinase 1B" Q9Y463 19 39825350-39834201 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Diabetes mellitus, Obesity" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 131.3;testis: 83.8" "Group enriched" "Detected in many" 12 "Early spermatids: 179.4;Late spermatids: 580.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "SH-SY5Y: 14.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028522, HPA028786" Uncertain Supported "Nucleoplasm,Mitotic chromosome" Yes No "Cluster 15: NK-cells - Transcription" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "Mitotic chromosome" "HPA028522: AB_2672656, HPA028786: AB_10670831" "unprognostic (2.22e-2)" "unprognostic (9.86e-2)" "unprognostic (4.55e-2)" "unprognostic (3.45e-3)" "unprognostic (1.96e-1)" "unprognostic (1.13e-2)" "unprognostic (2.25e-1)" "unprognostic (2.39e-1)" "unprognostic (6.02e-2)" "unprognostic (3.67e-2)" "unprognostic (8.93e-2)" "unprognostic (4.22e-2)" "prognostic favorable (8.83e-4)" "unprognostic (9.73e-2)" "unprognostic (1.12e-1)" "unprognostic (2.53e-2)" "unprognostic (3.88e-2)" 9.5 19.6 4.8 2.7 4.8 4.7 10.9 4.1 6.2 12.5 4.8 12.4 5.3 11.9 7.8 11.7 13.8 3.3 20.0 4.7 3.6 16.2 7.5 8.8 4.6 3.5 3.4 11.6 10.3 6.5 31.5 2.7 3.6 13.0 2.1 4.1 14.3 3.3 131.3 14.8 10.2 2.6 1.2 14.0 12.1 83.8 3.6 5.2 16.5 49.9 2.5 11.4 10.5 3.0 0.4 9.3 8.8 6.2 4.9 4.6 0.7 2.9 1.8 2.6 2.3 0.9 3.6 1.4 11.0 3.4 0.1 3.2 1.3 2.0 2.3 5.4 7.8 0.6 5.9 0.9 4.1 0.3 1.9 6.2 1.2 0.8 2.9 8.6 0.6 3.5 1.5 2.0 0.4 4.7 2.1 0.8 2.2 2.7 2.1 1.0 0.2 0.6 5.7 2.2 12.7 14.5 4.5 4.4 0.2 4.6 4.4 0.5 4.5 1.1 2.0 1.0 0.9 3.2 1.1 1.0 7.4 0.9 0.4 0.7 1.6 1.8 3.0 1.7 3.6 2.4 2.0 3.1 1.9 1.6 1.0 1.7 2.5 3.3 1.6 4.5 2.2 1.7 4.8 4.8 4.1 6.2 4.7 3.6 3.5 3.4 3.6 1.2 3.6 3.0 6.0 0.0 0.6 6.2 10.9 3.4 3.8 8.4 10.2 15.2 9.0 6.1 6.1 7.2 3.4 16.5 20.9 2.1 21.7 10.3 9.8 13.1 179.4 15.4 6.7 7.3 20.4 19.8 4.6 4.3 1.7 5.1 7.7 10.1 1.3 11.9 12.1 3.9 5.9 10.1 6.3 9.8 10.2 8.2 3.0 580.2 7.2 4.7 5.4 7.5 5.7 8.3 10.3 5.0 3.2 9.7 9.7 5.3 5.0 4.8 11.5 17.4 10.7 13.0 0.0 11.1 4.8 30.1 13.4 6.1 2.8 1.4 10.8 20.2 7.4 3.6 DYRK2 ENSG00000127334 "Dual specificity tyrosine phosphorylation regulated kinase 2" Q92630 12 67648338-67665406 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Ubl conjugation pathway" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 133.1;Horizontal cells: 80.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027230, HPA056902" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 15: NK-cells - Transcription" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm Cytosol "HPA027230: AB_1847925, HPA056902: AB_2683271" "unprognostic (5.86e-3)" "unprognostic (4.18e-1)" "unprognostic (4.08e-3)" "unprognostic (2.56e-3)" "unprognostic (1.18e-2)" "unprognostic (1.69e-1)" "unprognostic (3.37e-3)" "unprognostic (7.83e-2)" "unprognostic (2.83e-2)" "unprognostic (1.22e-1)" "unprognostic (1.04e-1)" "unprognostic (3.47e-1)" "unprognostic (2.12e-2)" "unprognostic (2.03e-2)" "unprognostic (1.38e-1)" "unprognostic (1.57e-1)" "unprognostic (1.35e-1)" 9.9 4.6 2.9 14.2 3.3 14.9 6.3 2.3 6.1 7.8 3.2 25.7 20.4 13.1 6.2 10.7 10.0 14.3 24.4 8.6 2.3 4.7 4.2 9.1 21.6 3.4 2.3 8.7 8.6 4.9 3.0 14.1 2.7 6.5 21.9 14.8 5.4 8.8 39.4 7.5 28.0 13.0 3.1 14.7 20.6 5.0 2.7 24.1 6.9 10.4 14.2 11.9 7.6 3.5 24.5 13.4 19.8 14.4 9.7 13.2 15.8 24.2 15.7 11.6 6.6 17.9 13.2 45.3 29.2 35.3 7.1 27.8 16.0 9.6 12.4 19.6 20.9 7.3 9.5 6.9 3.8 16.8 15.2 11.0 13.3 31.4 24.8 19.6 6.6 18.9 9.2 22.9 15.1 13.9 14.4 8.2 17.2 15.8 21.5 37.9 19.7 20.0 13.6 30.2 26.0 30.7 10.1 13.4 13.9 13.3 9.2 13.9 10.0 18.4 17.3 12.8 19.4 10.9 1.9 24.9 17.6 11.1 19.4 2.0 0.3 4.0 3.2 0.7 2.3 1.8 2.3 4.2 1.2 2.0 1.9 3.7 0.4 4.7 0.9 0.5 2.0 1.1 2.9 3.3 2.3 6.1 8.6 2.3 3.4 2.3 2.7 3.1 2.7 3.5 13.0 9.6 10.2 3.9 14.4 11.3 11.9 6.7 8.6 18.0 7.4 8.1 44.5 20.0 11.2 1.8 22.9 3.5 28.6 133.1 0.0 19.0 0.6 28.0 35.9 12.1 24.6 4.8 11.0 18.2 7.9 18.9 25.0 15.6 5.7 13.3 6.4 6.1 17.0 80.8 11.4 62.0 4.1 15.7 22.5 2.0 11.5 15.5 8.8 13.1 12.0 16.7 42.2 6.0 9.1 17.7 61.3 13.2 9.0 16.1 62.9 11.3 30.3 23.3 13.1 53.5 33.6 2.7 10.1 15.6 16.2 4.5 31.0 17.9 32.3 34.4 DYRK3 "hYAK3-2, RED, REDK" ENSG00000143479 "Dual specificity tyrosine phosphorylation regulated kinase 3" O43781 1 206635536-206684419 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 48.0" "Cell type enhanced" "Detected in many" "Early spermatids: 235.3;Late spermatids: 48.1;Spermatocytes: 108.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "plasmacytoid DC: 2.7" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "hTERT-HME1: 73.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA075041 Supported Nucleoplasm,Cytosol NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 30: Epithelial cell lines - Translation" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm Cytosol "HPA075041: AB_2686730" "unprognostic (6.51e-2)" "unprognostic (1.24e-2)" "unprognostic (3.36e-2)" "unprognostic (2.03e-1)" "unprognostic (2.81e-2)" "unprognostic (1.23e-1)" "unprognostic (1.20e-4)" "unprognostic (2.69e-1)" "unprognostic (3.91e-1)" "unprognostic (2.71e-1)" "unprognostic (2.79e-3)" "unprognostic (2.52e-1)" "prognostic unfavorable (9.41e-7)" "unprognostic (2.38e-1)" "unprognostic (2.04e-1)" "unprognostic (1.99e-2)" "unprognostic (7.62e-3)" 7.6 2.4 3.7 4.2 3.8 8.8 5.7 1.7 3.7 5.6 5.6 2.3 1.0 5.3 3.1 2.8 5.7 13.5 8.3 5.1 3.8 3.3 4.1 5.5 1.6 3.8 5.1 4.9 3.9 3.0 6.5 1.2 3.4 2.9 1.4 6.4 4.3 3.0 0.8 1.5 1.7 8.1 2.6 1.3 3.1 48.0 3.8 5.9 8.3 1.9 1.8 7.5 2.8 3.5 5.0 6.7 1.6 9.8 16.7 15.9 0.4 15.4 36.7 15.0 19.6 0.4 2.7 7.6 2.2 20.1 25.8 1.5 8.6 14.1 15.8 0.1 4.8 10.5 8.9 1.7 26.9 7.5 6.8 10.9 8.9 25.6 73.6 15.1 11.8 11.6 20.1 1.4 23.2 2.0 16.9 4.4 13.2 0.5 10.8 41.1 4.9 0.1 4.8 0.4 9.3 6.9 13.6 0.6 20.3 2.0 2.0 1.9 8.1 31.1 11.2 14.8 13.2 5.6 2.2 9.1 17.7 8.3 2.9 0.7 0.0 0.2 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.1 0.1 0.1 0.5 0.0 0.0 2.7 0.0 0.0 3.7 3.8 1.7 3.7 5.1 3.8 3.8 5.1 3.4 2.6 3.8 3.5 13.9 3.2 8.2 4.2 1.0 6.5 10.7 9.6 3.4 0.2 4.7 3.3 10.8 1.5 4.2 1.8 10.4 0.0 1.5 0.3 0.0 5.1 235.3 12.6 8.0 8.5 2.4 23.6 3.6 2.2 0.1 12.7 1.1 5.9 0.0 3.4 3.9 1.1 1.0 0.0 1.5 0.4 2.0 1.0 4.6 48.1 4.1 2.9 8.8 1.0 1.0 3.4 0.0 2.5 0.3 1.2 1.2 1.9 2.1 3.8 0.2 1.7 10.5 8.2 6.6 10.2 10.4 108.7 6.4 1.3 3.7 0.4 2.4 3.0 0.6 5.3 DYRK4 ENSG00000010219 "Dual specificity tyrosine phosphorylation regulated kinase 4" Q9NR20 12 4562204-4615302 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 36.7" "Group enriched" "Detected in all" 5 "Early spermatids: 392.2;Late spermatids: 393.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA028065, HPA056073" Enhanced Enhanced Vesicles No No "Cluster 14: Monocytes - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 34: Spermatids - Unknown function" Vesicles "HPA028065: AB_10601212, HPA056073: AB_2683028" "unprognostic (2.50e-1)" "unprognostic (1.55e-1)" "unprognostic (1.22e-1)" "unprognostic (3.56e-3)" "unprognostic (2.62e-1)" "unprognostic (4.07e-3)" "unprognostic (2.03e-2)" "unprognostic (4.69e-2)" "unprognostic (1.29e-1)" "unprognostic (7.13e-2)" "unprognostic (1.22e-2)" "unprognostic (2.46e-1)" "prognostic unfavorable (6.52e-6)" "unprognostic (1.86e-1)" "unprognostic (9.71e-2)" "unprognostic (1.04e-1)" "unprognostic (3.98e-2)" 2.1 4.2 3.9 3.4 4.2 4.6 6.4 5.1 7.6 5.9 4.2 5.4 4.6 5.0 17.0 4.0 5.0 4.4 4.7 4.2 4.4 3.5 4.2 4.7 5.9 4.4 4.5 5.1 3.0 5.0 3.6 6.8 4.8 5.0 6.2 7.7 3.7 7.2 2.2 4.9 4.0 5.1 4.1 6.2 3.2 36.7 4.8 4.3 9.1 4.1 5.4 4.7 2.0 5.7 2.0 3.2 3.9 4.3 5.8 7.1 4.7 2.4 4.8 5.4 5.9 0.6 3.2 6.1 0.3 6.9 3.7 4.2 3.0 4.5 4.2 4.7 6.8 4.2 1.0 3.6 16.4 3.7 3.3 4.9 9.6 3.8 12.4 10.1 7.8 6.5 1.8 6.7 4.9 4.3 3.5 9.1 5.3 1.0 1.8 0.7 2.8 2.6 6.7 1.9 0.0 1.5 0.5 2.4 3.3 8.4 1.9 3.3 0.5 6.3 4.9 0.6 3.1 1.9 2.6 3.8 3.3 5.8 3.3 0.3 1.7 0.8 0.5 1.3 0.6 4.4 0.8 0.9 1.6 3.0 0.8 0.9 0.0 0.7 3.5 0.8 0.7 0.8 3.9 4.2 5.1 7.6 4.2 4.4 4.4 4.5 4.8 4.1 4.8 5.7 13.0 12.8 16.2 11.1 15.8 8.9 13.2 31.2 14.8 20.7 21.2 30.4 23.8 7.2 19.9 16.5 10.4 15.7 16.7 5.2 31.3 25.1 392.2 14.0 22.5 15.5 5.4 12.2 10.3 27.1 12.0 17.3 14.3 13.3 17.7 19.0 8.2 9.8 49.7 13.5 10.4 75.4 14.2 16.1 9.3 393.1 15.2 18.7 16.0 9.4 14.5 19.4 13.4 14.1 16.1 20.1 14.2 31.6 22.9 16.4 7.3 35.6 13.9 21.7 6.6 15.2 17.6 23.7 39.0 20.4 7.5 9.9 12.7 40.6 17.3 11.8 DZIP3 "hRUL138, PPP1R66" ENSG00000198919 "DAZ interacting zinc finger protein 3" Q86Y13 3 108589705-108694840 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" "RNA-binding, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 327.4;Respiratory ciliated cells: 218.2;Spermatocytes: 351.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035066, HPA049232" Approved Approved Vesicles No No "Cluster 15: NK-cells - Transcription" "Cluster 77: Retina - Visual perception" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 49: Ciliated cells - Cilium organization" Vesicles "HPA035066: AB_10601549, HPA049232: AB_2680684" "unprognostic (1.14e-1)" "unprognostic (1.90e-1)" "unprognostic (7.68e-2)" "unprognostic (3.12e-2)" "unprognostic (2.15e-1)" "unprognostic (2.37e-2)" "unprognostic (3.33e-1)" "unprognostic (5.16e-2)" "unprognostic (2.74e-1)" "unprognostic (3.76e-2)" "unprognostic (2.59e-3)" "unprognostic (5.38e-2)" "prognostic favorable (3.65e-4)" "unprognostic (6.06e-2)" "unprognostic (2.78e-2)" "unprognostic (5.51e-3)" "unprognostic (3.81e-2)" 5.2 9.7 15.6 4.9 19.4 4.0 5.3 11.8 18.6 5.3 22.6 5.1 3.0 7.9 10.1 3.9 18.7 5.9 11.7 18.8 18.5 10.9 4.3 6.5 10.2 13.3 14.9 10.5 5.3 7.8 24.5 4.9 12.4 9.7 4.7 29.8 3.6 7.0 12.4 3.7 3.9 5.2 10.4 8.3 6.6 34.6 15.5 8.5 12.8 16.2 8.0 5.2 3.4 15.0 9.8 8.2 24.8 14.7 10.7 10.8 8.6 6.1 12.2 10.1 13.9 12.1 6.8 18.0 12.8 6.6 20.9 3.5 13.7 5.3 21.0 6.6 6.1 8.1 3.4 8.5 6.3 3.3 4.5 11.8 2.8 9.4 11.4 10.2 6.4 10.9 8.0 8.7 19.6 8.6 8.2 3.5 15.5 5.0 6.2 10.4 20.5 1.8 8.4 4.7 17.0 16.2 9.8 1.0 11.1 21.6 15.1 2.8 7.6 9.0 13.7 1.8 5.3 9.6 6.0 34.7 6.8 2.7 11.3 6.5 0.5 1.2 4.1 0.8 5.0 6.3 4.2 5.1 0.5 4.6 3.6 4.8 0.1 10.6 1.5 1.5 6.0 1.5 15.6 19.4 11.8 18.6 18.8 18.5 13.3 14.9 12.4 10.4 15.5 15.0 7.3 12.8 12.8 86.8 14.8 7.5 8.6 16.3 9.1 67.8 9.6 8.3 45.0 4.3 26.6 33.1 327.4 21.9 17.1 4.1 13.7 12.9 28.4 106.1 16.0 8.7 52.8 11.1 145.2 9.0 8.8 18.2 9.2 9.2 8.8 30.9 7.5 4.4 9.4 77.4 103.4 6.9 34.6 5.7 7.5 59.9 17.4 5.7 7.2 37.5 10.5 32.9 11.3 79.4 80.6 8.9 4.6 17.7 9.0 6.9 4.5 20.6 218.2 33.7 19.7 16.6 17.7 351.3 112.5 4.4 7.4 14.8 29.4 35.4 7.4 5.6 ECH1 HPXEL ENSG00000104823 "Enoyl-CoA hydratase 1" Q13011 19 38815422-38831841 "Metabolic proteins, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" Isomerase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 749.9;skeletal muscle: 906.9" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 796.9;Proximal tubular cells: 880.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002907, HPA005835" Supported Supported Supported Mitochondria No No 720000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 18: Non-specific - Mitochondria" "Cluster 43: THP-1 - Innate immune response" "Cluster 47: Cytotrophoblasts - Unknown function" Mitochondria "HPA002907: AB_1847964, HPA005835: AB_1847965" "unprognostic (1.91e-1)" "unprognostic (3.03e-2)" "unprognostic (3.64e-2)" "unprognostic (6.43e-2)" "unprognostic (5.73e-3)" "unprognostic (6.90e-2)" "unprognostic (1.28e-1)" "unprognostic (1.79e-1)" "unprognostic (2.43e-1)" "unprognostic (5.86e-2)" "unprognostic (2.24e-1)" "unprognostic (3.37e-1)" "unprognostic (7.01e-2)" "prognostic unfavorable (2.23e-4)" "unprognostic (3.54e-1)" "unprognostic (3.52e-1)" "unprognostic (1.74e-2)" 216.0 343.0 51.2 47.6 53.7 62.3 194.2 54.1 60.3 124.9 58.6 232.9 93.5 115.3 32.3 168.4 114.0 66.8 749.9 49.3 52.5 271.6 556.1 122.1 67.8 51.8 51.8 107.2 141.4 56.0 77.1 67.1 53.4 99.5 99.9 12.8 138.6 43.3 906.9 149.0 167.4 59.7 50.6 192.3 180.5 100.7 55.0 51.0 117.9 455.1 65.7 142.4 132.4 53.3 64.0 273.8 42.0 68.8 161.0 82.0 61.8 31.7 53.2 26.6 27.1 178.8 124.8 98.6 117.2 72.8 24.1 30.1 70.9 72.9 21.1 345.3 37.7 120.7 76.5 146.1 161.3 131.9 116.9 109.0 186.6 35.1 61.2 52.3 63.4 127.3 58.4 160.8 59.6 120.0 91.8 82.2 27.8 278.8 65.9 101.8 126.2 199.0 168.7 142.6 51.4 67.2 161.0 77.1 86.5 27.3 106.4 288.4 53.7 45.5 39.3 46.5 29.6 121.0 153.2 96.4 71.4 164.9 90.7 316.1 312.9 268.0 253.6 248.2 237.2 368.4 243.5 249.1 308.6 361.3 216.5 242.4 41.6 342.7 212.8 221.5 391.8 541.8 51.2 53.7 54.1 60.3 49.3 52.5 51.8 51.8 53.4 50.6 55.0 53.3 125.4 86.6 104.7 13.1 111.1 82.2 220.0 320.8 80.8 22.4 124.0 143.8 302.7 205.9 203.2 145.3 16.7 796.9 103.4 257.7 510.6 195.4 64.5 95.7 56.9 96.4 189.2 99.9 7.1 90.1 370.6 104.1 112.7 77.0 120.9 177.6 90.7 549.4 277.6 37.0 8.6 298.9 193.3 99.0 85.2 56.7 130.8 97.5 145.9 8.4 205.1 53.0 113.3 7.1 16.0 97.0 257.5 143.0 122.1 100.1 383.0 880.0 182.6 21.4 78.9 88.4 119.7 73.3 51.3 121.6 90.8 580.9 118.6 624.2 350.0 218.1 EGFL8 "C6orf8, NG3" ENSG00000241404 "EGF like domain multiple 8" Q99944 6 32164595-32168281 "Metabolic proteins, Predicted secreted proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 6.4;Granulosa cells: 10.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "Hep G2: 3.2;SK-MEL-30: 3.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA061173 Uncertain Approved "Nuclear speckles,Vesicles" "Secreted - unknown location" NA NA "Cluster 72: Non-specific - Transcription" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 40: Granulosa cells - Unknown function" Vesicles "Nuclear speckles" "HPA061173: AB_2684443" "unprognostic (7.13e-2)" "unprognostic (1.86e-1)" "unprognostic (6.79e-3)" "unprognostic (3.64e-1)" "unprognostic (1.30e-1)" "unprognostic (7.60e-4)" "unprognostic (3.42e-2)" "unprognostic (2.49e-1)" "unprognostic (6.42e-3)" "unprognostic (1.97e-1)" "unprognostic (7.60e-3)" "unprognostic (8.11e-3)" "unprognostic (1.07e-4)" "unprognostic (1.11e-1)" "unprognostic (6.79e-2)" "unprognostic (1.21e-1)" "unprognostic (3.29e-2)" 13.3 7.2 3.8 0.5 3.5 1.1 13.6 3.6 5.7 23.4 4.1 19.8 0.6 10.0 0.8 12.3 16.3 3.0 14.2 3.9 3.9 16.3 7.4 9.4 0.3 3.8 3.9 31.2 5.1 0.4 8.2 2.9 3.7 16.9 0.5 0.0 7.9 1.4 3.8 12.8 8.8 0.3 3.8 7.9 10.2 4.4 4.1 0.6 8.7 2.5 0.2 13.5 17.2 3.8 0.2 0.1 0.4 1.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.3 0.0 0.0 1.1 0.4 0.0 0.0 0.0 0.5 0.0 0.3 3.2 0.0 0.0 0.3 0.0 0.4 0.2 0.1 0.0 0.2 0.7 0.5 0.0 0.0 0.6 1.0 1.0 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.2 0.1 0.6 0.0 0.0 3.4 0.0 1.0 0.7 0.0 0.3 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.8 3.5 3.6 5.7 3.9 3.9 3.8 3.9 3.7 3.8 4.1 3.8 1.2 6.4 4.1 0.0 0.3 1.5 0.6 0.3 4.6 1.5 0.5 0.3 0.1 0.0 1.6 1.8 2.1 0.8 0.6 0.2 0.0 0.4 0.1 1.0 1.9 1.7 0.0 1.7 0.0 0.2 0.4 1.5 4.6 1.3 0.0 10.4 3.3 0.3 0.2 0.0 0.0 1.1 0.0 0.6 1.6 0.2 3.7 0.7 0.0 0.0 0.0 0.9 3.1 0.0 0.0 0.3 0.2 1.2 2.1 0.7 0.4 0.1 1.6 1.5 0.0 2.0 1.5 0.5 0.4 4.0 2.3 0.8 0.9 1.5 1.3 0.5 EHHADH ECHD ENSG00000113790 "Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase" Q08426 3 185190624-185281990 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" "Isomerase, Lyase, Multifunctional enzyme, Oxidoreductase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 11 "kidney: 144.3;liver: 344.5" "Group enriched" "Detected in many" 10 "Hepatocytes: 289.0;Proximal tubular cells: 147.1" "Group enriched" "Detected in all" 7 "liver cancer: 42.2;renal cancer: 25.4" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036401, HPA042021" Enhanced NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 39: CACO-2 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA036401: AB_10670165, HPA042021: AB_2677801" "unprognostic (1.20e-1)" "unprognostic (5.99e-2)" "unprognostic (2.17e-3)" "unprognostic (2.69e-2)" "unprognostic (6.82e-2)" "unprognostic (1.48e-1)" "unprognostic (4.79e-3)" "unprognostic (1.25e-1)" "unprognostic (1.73e-1)" "unprognostic (3.89e-2)" "unprognostic (3.19e-3)" "unprognostic (1.87e-1)" "prognostic favorable (1.28e-5)" "unprognostic (1.93e-1)" "unprognostic (1.53e-1)" "unprognostic (2.96e-2)" "unprognostic (2.80e-1)" 10.8 4.3 2.1 3.0 2.9 1.2 4.1 3.9 2.7 3.5 9.2 14.2 21.5 2.8 3.5 5.5 3.6 4.4 10.7 2.1 3.1 144.3 344.5 4.3 2.1 3.2 4.1 2.6 9.9 7.8 1.5 3.2 3.0 6.3 10.8 1.6 5.7 2.2 1.7 4.5 12.9 3.7 2.5 3.7 10.4 2.7 3.1 2.1 6.5 5.6 2.8 3.6 2.1 2.8 12.3 5.0 1.4 0.0 7.3 6.1 1.5 5.7 1.8 3.7 4.1 21.9 7.5 0.0 22.1 5.7 1.4 5.8 0.0 4.8 7.6 16.2 5.2 8.6 1.3 22.5 4.7 1.0 0.2 8.7 6.0 3.7 3.4 5.0 5.5 0.0 5.7 6.1 7.2 6.4 0.2 5.1 3.0 4.3 6.3 0.0 9.9 0.5 15.4 6.8 4.4 6.4 11.2 6.4 10.5 12.1 23.7 10.1 2.6 2.4 3.6 1.9 0.5 1.7 5.6 0.5 0.8 3.9 4.0 0.1 0.9 0.0 0.6 0.8 0.4 0.5 0.4 0.9 2.4 0.0 0.6 1.0 0.0 1.2 0.8 1.0 0.6 0.4 2.1 2.9 3.9 2.7 2.1 3.1 3.2 4.1 3.0 2.5 3.1 2.8 4.9 16.0 10.9 20.9 4.5 1.5 1.4 1.9 1.2 0.7 3.2 2.3 19.2 17.2 3.9 20.2 4.2 8.9 0.4 17.8 19.6 2.1 0.2 6.5 5.1 3.9 7.7 9.7 4.9 6.8 2.9 1.6 8.6 3.1 0.0 6.1 13.6 289.0 4.4 0.0 5.7 12.8 0.0 10.5 1.0 0.7 0.6 2.7 3.6 4.7 9.4 1.9 0.0 3.5 8.0 3.7 9.3 0.4 0.8 2.5 15.0 147.1 4.0 1.2 0.0 1.1 2.4 3.7 4.2 4.9 0.4 1.4 2.2 3.6 10.8 1.8 EIF2AK1 "HRI, KIAA1369" ENSG00000086232 "Eukaryotic translation initiation factor 2 alpha kinase 1" Q9BQI3 7 6022247-6059175 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Protein synthesis inhibitor, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Cytotrophoblasts: 219.1;Erythroid cells: 422.0;Syncytiotrophoblasts: 371.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016496, CAB022082, HPA061675" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 6: Erythroid cells - Oxygen transport" Nucleoplasm Cytosol "CAB022082: , HPA016496: AB_1848057, HPA061675: AB_2684583" "unprognostic (7.15e-3)" "unprognostic (2.00e-2)" "unprognostic (1.45e-1)" "unprognostic (2.91e-1)" "unprognostic (6.70e-2)" "unprognostic (9.69e-3)" "prognostic unfavorable (6.99e-4)" "unprognostic (2.36e-1)" "unprognostic (2.54e-1)" "unprognostic (1.07e-2)" "unprognostic (1.48e-1)" "unprognostic (8.96e-2)" "unprognostic (2.53e-1)" "unprognostic (1.99e-1)" "unprognostic (5.45e-2)" "unprognostic (9.02e-2)" "unprognostic (1.06e-2)" 27.2 39.4 28.1 27.7 28.9 105.9 35.9 30.6 36.1 29.0 34.9 48.8 37.1 25.0 37.4 30.4 31.0 23.8 33.8 28.1 30.6 43.8 65.1 30.3 35.2 30.5 28.9 29.3 44.3 78.0 25.9 52.3 31.6 35.0 47.3 29.0 46.8 24.2 38.3 33.3 37.2 23.8 29.1 26.6 49.1 19.5 29.8 43.6 39.3 34.4 40.4 27.2 22.4 33.7 144.5 90.5 71.2 108.8 66.4 59.6 92.4 73.0 66.8 64.2 80.8 83.7 96.2 112.5 77.4 81.3 115.5 100.4 93.1 67.1 82.2 69.8 140.3 115.9 91.6 127.3 54.3 100.8 102.0 48.1 82.8 60.7 64.9 67.7 69.4 88.1 189.0 106.8 61.4 146.5 55.6 128.6 88.5 84.6 99.7 120.0 74.6 134.0 82.3 70.3 87.3 156.5 139.3 186.6 63.8 98.6 141.0 122.4 65.9 37.0 134.2 65.3 78.2 106.5 114.8 115.6 73.9 129.8 108.7 11.1 6.9 17.3 8.2 5.5 5.6 12.3 6.5 9.3 6.9 9.5 7.5 6.6 3.7 10.2 6.2 6.0 8.9 4.8 28.1 28.9 30.6 36.1 28.1 30.6 30.5 28.9 31.6 29.1 29.8 33.7 23.1 38.5 43.7 14.4 42.8 23.8 34.9 34.3 41.5 29.7 52.5 34.9 49.6 45.8 37.7 44.1 16.7 219.1 52.5 57.1 66.5 55.0 8.8 59.5 42.3 27.5 38.5 422.0 21.8 44.8 82.1 29.7 64.7 48.1 20.8 44.9 21.0 63.2 53.8 32.0 21.9 68.7 54.9 39.0 29.9 16.1 34.5 65.2 24.9 13.1 62.8 46.4 70.0 19.1 26.9 53.0 47.0 37.6 60.1 43.3 47.5 66.1 48.3 26.5 13.1 32.0 26.0 33.7 34.5 45.5 22.4 371.0 38.0 57.1 52.7 32.3 EIF2AK2 "EIF2AK1, PKR, PPP1R83, PRKR" ENSG00000055332 "Eukaryotic translation initiation factor 2 alpha kinase 2" P19525 2 37099210-37157522 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Antiviral defense, Host-virus interaction, Immunity, Innate immunity, Transcription, Transcription regulation" "Kinase, RNA-binding, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003845, HPA019795, HPA063893" Approved Enhanced Cytosol NA NA 44000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Cytosol "CAB003845: AB_562332, HPA019795: AB_1848060, HPA063893: AB_2685144" "unprognostic (1.70e-2)" "unprognostic (2.26e-1)" "unprognostic (1.62e-1)" "prognostic unfavorable (3.77e-4)" "unprognostic (1.66e-1)" "unprognostic (1.04e-1)" "unprognostic (1.77e-3)" "unprognostic (8.42e-2)" "unprognostic (8.02e-2)" "unprognostic (4.67e-2)" "prognostic unfavorable (2.08e-4)" "unprognostic (1.19e-1)" "unprognostic (3.15e-3)" "unprognostic (3.33e-1)" "unprognostic (1.74e-1)" "unprognostic (4.65e-2)" "unprognostic (5.32e-2)" 11.1 9.0 7.2 10.5 8.1 30.1 8.6 7.4 9.5 9.8 8.6 8.8 7.6 10.5 8.0 6.3 8.3 9.5 6.3 7.8 11.1 8.5 7.7 8.9 8.0 10.9 8.1 10.8 7.4 11.1 6.6 11.2 10.9 10.1 8.6 6.6 17.7 8.4 4.5 4.6 9.9 11.1 15.6 11.9 9.5 3.3 13.0 11.7 10.0 5.8 7.1 8.0 5.9 8.7 38.4 22.1 16.7 17.4 21.5 28.3 20.1 21.2 29.1 56.3 41.1 23.0 23.2 27.4 27.0 29.8 66.2 27.4 24.2 27.1 29.5 45.7 12.0 33.8 19.2 18.7 17.9 32.2 0.2 22.5 13.1 23.7 19.3 17.7 18.0 10.7 19.1 23.6 20.3 13.4 35.5 17.0 15.8 8.4 10.8 27.6 40.9 12.1 15.3 18.7 14.1 20.4 32.0 24.0 50.7 12.7 9.2 9.0 31.4 25.7 24.9 15.1 36.2 19.0 30.8 0.3 15.9 20.0 23.1 10.7 5.3 6.3 5.4 7.9 5.2 5.3 4.5 5.2 4.8 4.2 3.0 4.3 15.7 6.5 8.0 3.1 6.5 2.1 7.2 8.1 7.4 9.5 7.8 11.1 10.9 8.1 10.9 15.6 13.0 8.7 94.5 67.3 34.0 25.1 35.9 19.5 42.3 33.0 31.3 38.8 26.6 26.0 29.9 32.9 46.0 22.0 14.6 47.8 44.8 32.2 21.5 40.2 2.4 55.8 68.7 76.3 15.0 36.0 39.6 48.5 89.2 52.6 22.4 41.7 41.1 93.5 33.5 21.9 38.2 47.1 42.9 24.0 16.2 29.9 20.8 4.2 57.2 50.7 21.4 48.7 47.1 50.9 45.3 51.3 16.8 54.7 21.8 84.2 46.0 39.5 33.6 33.0 48.9 24.8 39.5 60.5 45.9 2.4 5.5 22.5 10.1 40.8 40.0 61.3 28.6 40.5 EIF2AK3 "PEK, PERK" ENSG00000172071 "Eukaryotic translation initiation factor 2 alpha kinase 3" Q9NZJ5 2 88556741-88627464 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Stress response, Translation regulation, Unfolded protein response" "Kinase, Serine/threonine-protein kinase, Transferase" "Diabetes mellitus, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pancreas: 19.6" "Cell type enhanced" "Detected in many" "Plasma cells: 121.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "naive B-cell: 1.9" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "Daudi: 46.8;U-266/70: 44.0;U-698: 31.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009204, HPA015737" Approved NA NA "Cluster 24: B-cells - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" "CAB009204: AB_2230863, HPA015737: AB_1848062" "unprognostic (7.25e-3)" "unprognostic (5.35e-2)" "unprognostic (3.03e-3)" "unprognostic (9.32e-2)" "unprognostic (9.39e-3)" "unprognostic (3.25e-2)" "unprognostic (2.27e-2)" "unprognostic (3.46e-3)" "unprognostic (9.84e-2)" "unprognostic (3.50e-1)" "unprognostic (1.89e-1)" "unprognostic (2.31e-1)" "unprognostic (2.06e-1)" "unprognostic (2.92e-1)" "unprognostic (9.80e-2)" "unprognostic (3.60e-3)" "unprognostic (2.90e-3)" 3.3 3.1 0.8 4.0 1.1 2.6 1.6 1.6 1.4 2.3 1.6 4.7 6.2 1.9 1.0 1.6 1.3 1.4 1.5 0.8 1.5 2.0 1.9 1.8 3.2 1.0 1.2 1.9 19.6 3.4 1.1 3.2 0.9 4.0 1.8 0.1 9.7 1.2 2.0 1.4 5.0 0.9 1.5 3.1 12.3 1.0 1.2 1.3 3.5 0.0 2.3 1.9 1.8 2.1 8.7 3.3 1.2 4.3 2.8 2.0 15.9 12.4 1.1 0.7 2.1 3.5 2.9 46.8 8.0 1.3 3.1 7.2 1.6 1.3 1.1 25.3 7.1 4.6 1.7 2.0 1.1 3.9 12.3 0.1 1.5 0.7 2.0 0.8 1.4 4.9 3.0 8.7 0.6 4.4 5.5 2.2 6.2 2.7 7.2 25.1 7.0 8.2 1.3 5.0 5.6 9.9 6.3 6.5 8.2 1.7 2.2 4.4 3.9 2.5 5.5 10.8 7.1 44.0 24.4 31.0 4.6 4.2 6.2 0.0 0.1 0.1 0.3 0.0 0.2 1.0 0.2 0.8 0.1 1.9 0.2 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.8 1.1 1.6 1.4 0.8 1.5 1.0 1.2 0.9 1.5 1.2 2.1 9.2 9.6 7.5 14.7 43.8 20.3 8.9 7.2 26.7 8.4 14.7 8.9 8.2 17.2 7.2 12.9 8.4 4.1 13.4 14.0 0.0 3.7 0.1 18.4 18.3 7.6 13.7 1.7 31.3 6.5 6.9 15.2 40.2 39.2 1.3 4.4 8.9 11.8 4.6 1.7 39.0 30.1 14.2 5.1 41.2 0.7 7.5 27.7 32.0 21.5 3.9 3.0 9.2 20.1 26.2 7.0 7.7 5.7 121.3 13.0 5.4 2.9 7.7 2.3 0.0 13.4 9.4 3.1 3.6 23.8 18.3 6.7 12.8 3.5 6.8 16.6 EIF2AK4 "GCN2, KIAA1338" ENSG00000128829 "Eukaryotic translation initiation factor 2 alpha kinase 4" Q9P2K8 15 39934115-40035591 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Activation of host autophagy by virus, Adaptive immunity, Antiviral defense, Cell cycle, Growth arrest, Host-virus interaction, Immunity, Neurogenesis, Stress response, Translation regulation" "Activator, Kinase, RNA-binding, Serine/threonine-protein kinase, Transferase, tRNA-binding" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "plasmacytoid DC: 66.5" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011811 Approved Approved Cytosol NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 15: Liver - Metabolism" "Cluster 44: HDLM-2 - Immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Cytosol "HPA011811: AB_2668543" "unprognostic (3.10e-1)" "unprognostic (4.78e-3)" "unprognostic (5.97e-2)" "unprognostic (7.18e-2)" "unprognostic (1.05e-2)" "unprognostic (3.32e-2)" "unprognostic (1.18e-1)" "unprognostic (3.18e-1)" "unprognostic (1.36e-1)" "unprognostic (1.21e-1)" "unprognostic (1.38e-2)" "unprognostic (7.27e-2)" "unprognostic (2.38e-1)" "unprognostic (1.27e-2)" "unprognostic (6.47e-2)" "unprognostic (2.31e-2)" "unprognostic (5.11e-3)" 20.1 14.6 21.5 12.2 22.4 18.7 17.6 27.2 23.7 14.6 16.8 15.5 11.3 30.5 15.4 16.0 16.1 17.0 17.7 21.2 22.0 13.4 21.3 16.9 16.9 20.3 20.2 17.1 14.1 17.7 24.1 19.0 20.5 19.8 12.9 13.1 13.9 11.5 18.9 19.0 11.3 15.6 18.9 15.7 15.2 8.9 22.1 13.1 21.8 11.0 11.6 17.2 12.4 28.9 37.1 17.5 30.3 46.3 49.0 81.7 28.9 51.0 58.1 40.8 40.0 25.2 15.6 19.6 25.9 69.3 54.7 38.6 41.1 61.4 56.6 92.8 20.4 41.6 30.8 30.7 42.1 25.6 27.8 65.3 41.2 39.0 69.8 57.3 58.0 40.5 31.3 18.1 81.7 12.3 21.7 34.6 18.8 32.8 38.2 25.4 42.2 33.1 51.4 24.7 16.1 24.4 36.4 22.2 32.3 29.5 30.7 43.4 61.6 54.3 40.9 27.3 33.6 24.6 47.8 6.0 38.1 34.4 77.4 11.6 10.8 8.6 6.8 14.1 5.7 7.1 7.6 7.9 17.6 9.2 8.3 8.2 3.3 8.5 20.5 66.5 5.8 4.9 21.5 22.4 27.2 23.7 21.2 22.0 20.3 20.2 20.5 18.9 22.1 28.9 47.9 16.0 31.1 28.7 29.3 12.0 27.5 17.8 43.3 29.9 45.0 45.2 32.3 32.9 21.4 16.5 12.5 37.5 32.2 21.1 13.7 23.7 1.5 19.3 52.7 35.3 14.4 37.4 42.7 25.4 34.8 36.5 23.4 27.0 24.1 35.0 22.9 27.8 30.7 28.6 53.9 25.9 12.2 33.7 55.4 4.3 42.3 52.1 32.0 29.0 41.1 30.4 16.5 30.2 26.3 47.6 16.2 39.9 115.6 30.7 6.4 18.2 12.9 23.9 46.0 43.6 35.6 8.6 29.8 47.0 14.5 15.2 18.2 64.0 29.6 18.4 EIF4EBP3 4E-BP3 ENSG00000243056 "Eukaryotic translation initiation factor 4E binding protein 3" O60516 5 140547662-140549576 "Metabolic proteins, Predicted intracellular proteins" "Translation regulation" "Protein synthesis inhibitor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 59.2;Exocrine glandular cells: 29.0;Gastric mucus-secreting cells: 26.5;Proximal enterocytes: 43.3;Squamous epithelial cells: 42.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HHSteC: 25.1;JURKAT: 42.3;Karpas-707: 28.9" "Low region specificity" "Detected in some" HPA045537 Uncertain NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 59: Non-specific - Transcription" "HPA045537: AB_10965796" "unprognostic (7.29e-2)" "unprognostic (4.20e-2)" "unprognostic (1.14e-1)" "unprognostic (2.44e-1)" "unprognostic (6.64e-2)" "unprognostic (4.84e-3)" "unprognostic (2.70e-1)" "unprognostic (1.24e-1)" "unprognostic (2.57e-1)" "unprognostic (8.36e-2)" "unprognostic (4.87e-3)" "unprognostic (2.17e-1)" "prognostic favorable (3.10e-4)" "unprognostic (1.05e-1)" "unprognostic (1.42e-1)" "unprognostic (8.82e-2)" "unprognostic (3.75e-1)" 43.7 66.1 23.2 6.4 24.2 12.5 45.6 24.9 29.6 27.0 25.4 38.4 12.7 21.8 6.9 36.8 36.9 17.0 42.8 22.8 25.5 41.1 55.4 26.0 12.1 25.2 23.9 30.0 49.0 2.9 17.0 7.0 25.1 41.3 17.4 2.6 54.2 15.5 121.8 49.2 39.9 8.6 25.0 31.1 59.1 32.1 23.4 12.6 35.6 55.7 9.2 30.0 28.7 25.6 0.4 1.7 1.5 2.3 18.4 19.2 3.4 1.6 0.4 0.9 1.6 3.4 1.4 0.9 8.7 3.6 1.3 1.3 0.7 1.8 1.1 3.1 5.6 0.2 3.8 6.3 25.1 10.3 4.9 23.6 2.3 1.5 1.2 4.5 2.8 42.3 0.6 28.9 1.1 0.0 7.9 18.6 2.2 5.3 6.3 8.3 1.2 0.3 2.9 3.6 9.1 1.3 2.8 23.1 7.6 2.0 3.1 11.9 2.2 7.8 1.5 5.0 1.2 2.6 2.3 0.9 5.4 20.0 2.1 9.4 43.6 1.4 11.3 51.2 14.1 41.3 20.5 10.3 37.7 37.1 41.7 34.1 22.3 24.1 38.6 117.5 17.6 24.3 23.2 24.2 24.9 29.6 22.8 25.5 25.2 23.9 25.1 25.0 23.4 25.6 0.8 0.0 13.7 0.0 8.0 0.3 0.6 0.7 59.2 0.0 6.5 3.2 0.2 7.2 4.6 0.0 0.0 0.8 1.5 13.0 3.9 8.6 1.1 4.9 0.9 2.8 8.5 11.8 0.0 29.0 0.9 8.0 26.5 1.5 12.0 0.1 2.2 7.2 2.4 0.0 0.0 15.1 0.0 5.7 0.2 1.1 1.8 9.0 0.0 0.0 7.1 0.0 1.0 0.0 0.0 14.2 19.4 0.0 0.9 0.8 43.3 7.9 7.8 0.0 0.0 0.6 1.2 2.6 0.6 42.3 0.6 1.0 3.4 0.2 18.8 0.4 ELP3 "FLJ10422, KAT9" ENSG00000134014 "Elongator acetyltransferase complex subunit 3" Q9H9T3 8 28089673-28191156 "Disease related genes, Metabolic proteins, Predicted intracellular proteins" "Neurogenesis, Transcription, Transcription regulation, tRNA processing" "Acyltransferase, RNA-binding, Transferase, tRNA-binding" "Amyotrophic lateral sclerosis, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 74.3;Glandular and luminal cells: 125.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA025297, HPA025812" Uncertain Enhanced Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 80: Striated muscle - Unknown function" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 44: Endometrium - Transcription" Cytosol "HPA025297: , HPA025812: AB_10601369" "unprognostic (1.29e-2)" "unprognostic (1.26e-2)" "prognostic favorable (9.25e-4)" "unprognostic (3.49e-3)" "unprognostic (5.73e-2)" "unprognostic (1.10e-1)" "unprognostic (6.95e-2)" "unprognostic (2.07e-2)" "unprognostic (7.66e-2)" "unprognostic (1.22e-2)" "unprognostic (3.89e-1)" "unprognostic (3.46e-2)" "prognostic favorable (1.31e-5)" "unprognostic (2.29e-1)" "unprognostic (1.94e-1)" "unprognostic (1.39e-1)" "unprognostic (1.71e-1)" 13.6 13.0 17.3 11.0 19.0 6.6 16.6 19.0 20.3 26.1 14.1 13.8 9.7 22.6 11.3 12.2 16.1 15.4 16.3 19.2 19.8 17.5 21.0 12.1 16.3 18.2 17.4 16.1 10.9 16.8 11.6 12.0 18.5 13.4 15.6 12.4 9.8 19.2 27.9 12.0 11.1 14.9 18.0 13.7 10.7 14.2 20.1 14.6 18.3 26.5 19.5 13.6 10.6 19.6 34.5 36.3 26.1 21.7 28.9 27.8 17.6 17.7 26.6 31.9 31.2 23.9 14.7 60.0 24.6 27.7 31.3 21.5 26.3 34.3 41.2 11.2 12.4 38.0 21.9 41.3 27.7 21.4 27.5 32.7 48.4 24.4 36.5 26.2 32.4 41.3 46.2 34.8 32.9 20.9 47.3 30.1 28.9 29.5 12.0 34.4 24.4 24.2 33.8 25.5 13.6 25.5 18.1 14.4 28.4 21.3 29.2 24.2 25.7 23.6 35.2 26.8 26.5 14.4 25.9 45.2 26.7 24.7 26.8 20.2 16.1 12.9 25.0 22.2 28.7 17.9 21.8 26.0 18.3 21.2 18.7 22.1 3.8 25.0 27.0 17.3 23.5 19.1 17.3 19.0 19.0 20.3 19.2 19.8 18.2 17.4 18.5 18.0 20.1 19.6 8.8 3.2 12.7 26.4 14.4 2.7 7.1 10.2 10.8 8.5 6.8 8.9 16.6 7.2 11.1 7.3 22.9 15.1 12.5 6.3 7.9 12.5 7.4 74.3 25.0 10.1 1.2 9.4 32.2 9.9 14.8 9.5 9.7 125.2 8.2 12.8 10.4 19.0 14.9 15.2 38.7 7.0 0.0 13.2 4.0 4.8 8.4 9.6 1.8 31.9 9.6 8.7 24.7 49.3 45.9 9.3 11.3 10.1 11.0 7.6 9.9 13.1 10.6 12.2 0.0 9.5 8.4 20.2 17.7 6.9 2.4 10.4 13.7 15.6 10.5 5.4 EP300 "KAT3B, p300" ENSG00000100393 "E1A binding protein p300" Q09472 22 41092592-41180077 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, Cell cycle, Host-virus interaction, Transcription, Transcription regulation" "Acyltransferase, Transferase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000146, HPA003128, HPA004112" Supported Enhanced Nucleoplasm NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 44: Endometrium - Transcription" Nucleoplasm "CAB000146: AB_2533138, HPA003128: AB_1078745, HPA004112: AB_1078746" "unprognostic (7.67e-2)" "unprognostic (5.56e-2)" "unprognostic (2.29e-1)" "unprognostic (2.52e-1)" "unprognostic (6.10e-3)" "unprognostic (1.66e-1)" "unprognostic (2.21e-2)" "unprognostic (2.13e-1)" "unprognostic (1.54e-1)" "unprognostic (8.97e-2)" "unprognostic (1.74e-2)" "unprognostic (8.54e-2)" "prognostic favorable (7.45e-5)" "unprognostic (7.97e-2)" "unprognostic (1.41e-1)" "unprognostic (1.01e-1)" "unprognostic (8.66e-2)" 15.7 13.7 6.8 17.7 8.9 65.1 14.2 20.5 10.8 16.0 6.1 16.6 13.6 17.2 13.5 16.3 16.4 14.2 11.5 7.1 9.4 13.1 15.5 14.7 17.6 10.6 7.8 23.9 18.0 23.2 13.4 19.3 7.7 15.0 14.5 17.8 15.0 15.6 20.4 18.9 16.0 16.4 5.3 17.0 14.5 19.6 8.6 27.2 20.2 23.4 17.9 15.4 14.8 11.2 31.6 21.7 35.4 23.0 22.2 23.3 32.3 15.0 21.8 21.0 21.0 27.8 12.0 32.7 12.2 28.4 18.7 24.1 48.1 20.8 23.5 30.5 32.2 24.4 25.4 22.3 26.9 59.3 26.5 24.8 22.2 30.0 27.0 19.3 24.9 18.7 26.3 43.9 18.3 12.5 16.2 18.9 27.5 38.3 15.2 33.7 16.7 21.3 20.3 40.4 11.3 11.9 51.1 26.0 25.6 29.5 17.8 33.9 31.3 20.3 24.8 16.3 20.8 28.5 14.1 47.9 16.3 17.4 21.5 3.6 1.7 1.6 1.6 1.9 1.5 2.2 1.7 1.7 2.1 1.4 1.4 1.1 4.9 2.7 1.0 1.6 1.4 1.2 6.8 8.9 20.5 10.8 7.1 9.4 10.6 7.8 7.7 5.3 8.6 11.2 45.4 67.3 49.2 58.1 53.8 24.6 22.9 11.6 40.9 44.6 35.1 25.8 31.6 38.6 15.8 25.8 35.5 18.4 63.2 37.0 3.9 16.1 15.3 55.1 56.4 36.2 24.7 60.4 71.8 18.7 17.9 32.0 27.5 72.5 25.3 36.1 32.9 29.2 18.4 25.2 73.6 24.2 2.0 60.7 25.7 6.4 28.9 60.5 8.8 45.9 52.0 27.7 40.2 81.4 80.3 25.8 28.9 30.5 51.2 30.8 20.2 10.8 22.8 30.9 26.3 47.6 36.7 22.8 31.2 35.3 25.9 30.2 46.0 36.7 23.7 36.3 EPM2A "LD, LDE" ENSG00000112425 "EPM2A glucan phosphatase, laforin" O95278 6 145382535-145736023 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, Carbohydrate metabolism, Glycogen metabolism" "Hydrolase, Protein phosphatase" "Disease variant, Epilepsy, Glycogen storage disease, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 76.8;tongue: 79.5" "Cell type enhanced" "Detected in many" "Astrocytes: 66.9;Early spermatids: 33.0;Excitatory neurons: 30.4;Inhibitory neurons: 50.7;Oligodendrocyte precursor cells: 56.8;Oligodendrocytes: 60.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "NK-cell: 1.9" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "Daudi: 23.2" "Low region specificity" "Detected in all" "HPA053643, HPA055468" Enhanced Nucleoplasm NA NA "Cluster 15: NK-cells - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA053643: AB_2797247, HPA055468: AB_2797252" "unprognostic (2.37e-2)" "unprognostic (1.03e-1)" "unprognostic (1.99e-1)" "unprognostic (3.34e-3)" "unprognostic (2.92e-3)" "unprognostic (1.22e-1)" "unprognostic (2.15e-2)" "unprognostic (1.63e-1)" "unprognostic (2.37e-2)" "unprognostic (1.50e-1)" "unprognostic (1.52e-4)" "unprognostic (2.28e-1)" "prognostic favorable (4.08e-7)" "unprognostic (4.12e-4)" "unprognostic (2.17e-1)" "unprognostic (2.99e-3)" "unprognostic (1.23e-1)" 5.8 6.0 11.4 1.5 11.7 1.8 3.2 11.9 17.8 3.1 7.3 17.2 3.2 6.0 4.3 9.3 4.4 3.6 24.4 11.6 12.6 8.5 5.7 3.0 3.3 11.9 11.5 5.7 2.4 5.2 3.8 1.5 11.1 6.1 2.9 12.1 3.1 8.8 76.8 2.1 3.8 6.3 10.3 2.1 5.3 3.0 11.5 4.8 3.9 79.5 2.6 9.8 2.7 13.3 1.3 2.1 3.4 6.6 8.6 2.3 1.6 3.1 3.8 2.9 3.5 1.7 1.7 23.2 2.7 3.8 3.5 1.8 1.3 1.6 2.6 9.3 1.9 3.6 2.5 2.7 4.8 12.7 2.4 2.0 7.0 1.7 0.7 3.8 2.0 5.0 1.8 5.4 3.8 3.1 8.4 3.2 3.9 3.2 1.9 4.8 3.1 6.7 2.5 1.8 6.3 6.4 5.5 3.3 7.8 3.1 1.9 7.3 4.6 2.9 1.1 2.7 2.6 4.1 4.6 8.6 2.6 2.8 4.8 0.0 0.0 0.0 0.1 0.5 0.4 0.4 0.4 0.3 0.3 0.4 0.4 0.9 0.1 1.9 0.1 0.3 0.0 0.3 11.4 11.7 11.9 17.8 11.6 12.6 11.9 11.5 11.1 10.3 11.5 13.3 3.9 6.4 1.5 66.9 4.4 0.9 1.0 0.8 0.6 8.4 3.5 2.2 27.8 2.8 2.2 1.8 6.2 1.0 1.9 0.2 11.7 1.0 33.0 1.9 3.6 2.2 1.2 4.4 30.4 2.3 0.7 2.3 1.1 1.4 2.5 6.0 1.4 6.6 2.3 30.3 50.7 1.5 2.0 3.3 1.4 19.8 3.1 3.1 7.2 15.9 1.7 7.9 2.1 56.8 60.1 1.2 1.7 2.2 1.7 1.5 0.5 7.1 2.2 6.3 0.0 6.2 2.4 4.9 1.6 0.8 0.4 0.4 1.8 5.1 1.2 0.3 ERN1 "IRE1, IRE1P" ENSG00000178607 "Endoplasmic reticulum to nucleus signaling 1" O75460 17 64039080-64130819 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Apoptosis, Transcription, Transcription regulation, Unfolded protein response" "Hydrolase, Kinase, Multifunctional enzyme, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 53.0;pancreas: 66.7" "Cell type enhanced" "Detected in many" "Plasma cells: 325.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 17.9" "Group enriched" "Detected in many" 5 "dendritic cells: 7.7;granulocytes: 17.9;T-cells: 9.0" "Cell line enhanced" "Detected in many" "Karpas-707: 74.6;RPMI-8226: 40.2;U-266/70: 77.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009495, HPA027730" Supported NA Yes "Cluster 38: Basophils - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 29: U-266 - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" "CAB009495: AB_2098712, HPA027730: AB_10602494" "unprognostic (2.52e-1)" "unprognostic (1.16e-2)" "unprognostic (1.89e-1)" "unprognostic (4.05e-3)" "unprognostic (3.63e-2)" "unprognostic (2.81e-2)" "unprognostic (9.14e-2)" "unprognostic (2.72e-2)" "unprognostic (4.55e-1)" "unprognostic (6.17e-2)" "unprognostic (2.95e-1)" "unprognostic (1.33e-1)" "prognostic unfavorable (1.68e-4)" "unprognostic (4.65e-1)" "unprognostic (1.89e-1)" "unprognostic (1.36e-2)" "unprognostic (3.11e-2)" 9.5 53.0 1.5 5.4 1.7 13.4 7.5 2.6 3.2 22.6 2.1 7.7 6.3 10.1 6.4 9.5 14.3 6.2 6.1 1.6 2.4 5.6 23.5 16.5 5.8 1.7 1.0 16.9 66.7 4.3 19.5 5.6 1.3 9.9 4.5 8.8 15.7 7.1 6.8 11.3 10.6 5.6 1.0 15.8 16.2 2.8 1.6 6.8 10.2 2.4 6.6 8.3 11.7 1.7 4.0 4.0 2.2 4.8 4.8 4.4 9.8 4.1 9.7 2.8 1.3 2.5 2.3 6.6 3.2 2.8 3.5 3.6 1.9 4.5 6.1 1.6 1.5 6.0 3.2 2.4 19.6 3.2 2.1 3.8 8.1 6.4 21.5 3.5 5.0 4.7 4.2 74.6 2.8 3.9 4.5 1.0 0.6 3.6 3.2 4.2 4.2 40.2 1.1 5.5 7.1 3.5 4.3 6.1 5.7 3.5 3.8 5.9 5.9 2.5 4.1 6.4 2.7 77.4 23.9 4.8 4.0 2.1 4.2 17.9 0.9 0.4 4.9 0.4 9.0 0.2 3.3 4.1 0.4 0.3 0.9 0.9 4.9 2.5 0.3 7.7 0.8 1.0 1.5 1.7 2.6 3.2 1.6 2.4 1.7 1.0 1.3 1.0 1.6 1.7 31.9 0.0 36.1 7.2 27.8 22.0 54.3 8.3 15.4 4.0 35.0 29.7 8.6 11.5 8.6 12.9 6.2 8.1 106.4 10.0 1.9 12.6 2.3 26.1 49.1 18.3 79.7 11.2 8.6 27.3 8.8 42.2 52.0 79.4 8.2 11.8 13.9 26.8 8.0 3.3 6.1 8.2 8.2 15.7 71.3 1.7 4.7 60.4 74.7 12.2 10.2 3.5 28.8 6.0 4.6 17.9 7.3 6.0 325.8 44.7 7.9 4.4 6.1 26.5 0.0 19.0 25.7 4.0 4.1 27.7 45.0 54.9 88.2 12.0 9.6 60.1 ERN2 IRE1b ENSG00000134398 "Endoplasmic reticulum to nucleus signaling 2" Q76MJ5 16 23690310-23713226 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Transcription, Transcription regulation" "Hydrolase, Kinase, Multifunctional enzyme, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "cervix: 19.5;gallbladder: 17.0;intestine: 28.9;salivary gland: 22.9;stomach 1: 51.9" "Cell type enhanced" "Detected in some" "Club cells: 38.4;Distal enterocytes: 80.2;Gastric mucus-secreting cells: 193.7;Intestinal goblet cells: 143.9;Paneth cells: 37.2;Undifferentiated cells: 70.9" "Cancer enhanced" "Detected in many" "colorectal cancer: 17.0;pancreatic cancer: 19.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 6 "OE19: 43.6" "Not detected" "Not detected" "Not detected" "Not detected" HPA076875 Approved Approved "Endoplasmic reticulum,Cytosol" "Intracellular and membrane" NA NA "Cluster 11: Basophils - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 27: Mucus-secreting cells - Mucin production" "Endoplasmic reticulum, Cytosol" "HPA076875: " "unprognostic (1.06e-1)" "unprognostic (5.20e-2)" "unprognostic (3.45e-1)" "unprognostic (2.98e-2)" "unprognostic (3.83e-2)" "unprognostic (1.13e-2)" "unprognostic (7.67e-4)" "unprognostic (1.31e-1)" "unprognostic (1.16e-1)" "unprognostic (4.93e-2)" "unprognostic (7.34e-2)" "unprognostic (1.19e-1)" "unprognostic (1.14e-9)" "unprognostic (1.48e-1)" "unprognostic (2.14e-1)" "unprognostic (1.06e-1)" "unprognostic (3.13e-3)" 0.1 0.4 0.1 3.0 0.1 0.0 0.1 0.6 0.4 19.5 0.2 28.9 12.9 0.0 0.0 0.9 0.4 17.0 0.0 0.1 0.2 0.1 0.0 0.8 0.0 0.2 0.1 0.0 0.9 0.0 0.2 0.0 0.2 3.5 23.0 0.0 22.9 0.1 0.0 0.2 12.4 0.9 0.0 0.0 51.9 0.1 0.1 0.0 0.0 0.0 0.0 4.6 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 6.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 43.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.2 0.0 0.1 0.0 0.0 0.1 0.1 0.6 0.4 0.1 0.2 0.2 0.1 0.2 0.0 0.1 0.4 0.0 0.0 1.1 0.0 0.8 0.0 1.5 6.8 0.0 0.0 0.0 0.0 0.5 20.0 38.4 0.0 0.0 0.5 0.0 80.2 0.0 2.3 0.1 0.5 0.2 0.1 10.8 0.0 0.2 1.9 0.0 0.1 193.7 1.6 4.5 0.1 0.0 0.0 0.1 0.0 0.1 143.9 6.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.0 0.1 33.1 37.2 0.0 0.5 1.3 6.1 0.1 16.9 0.0 0.0 1.7 1.6 0.0 0.2 0.0 0.0 0.1 0.4 0.0 70.9 11.1 F13A1 F13A ENSG00000124491 "Coagulation factor XIII A chain" P00488 6 6144084-6321013 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Blood coagulation, Hemostasis" "Acyltransferase, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adipose tissue: 232.8;placenta: 489.2" "Cell type enhanced" "Detected in many" "Hofbauer cells: 863.3;Langerhans cells: 205.1;Macrophages: 232.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "classical monocyte: 141.1;myeloid DC: 179.6" "Group enriched" "Detected in many" 184 "dendritic cells: 179.6;granulocytes: 50.2;monocytes: 141.1" "Cell line enhanced" "Detected in some" "AF22: 24.0;LHCN-M2: 8.9;RH-30: 43.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in some" "HPA001804, CAB002155" Enhanced "Secreted to blood" NA NA 1400000000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 28: Placenta - Pregnancy" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 4: Macrophages - Innate immune response" "CAB002155: AB_564077, HPA001804: AB_1078792" "unprognostic (4.44e-1)" "unprognostic (5.90e-2)" "unprognostic (2.65e-2)" "unprognostic (3.93e-2)" "unprognostic (5.02e-2)" "unprognostic (3.75e-2)" "unprognostic (5.27e-2)" "unprognostic (1.96e-1)" "unprognostic (2.68e-2)" "unprognostic (6.84e-3)" "unprognostic (4.96e-2)" "unprognostic (1.97e-1)" "prognostic unfavorable (6.61e-6)" "unprognostic (2.79e-2)" "unprognostic (1.52e-1)" "unprognostic (1.57e-1)" "unprognostic (2.54e-3)" 232.8 57.9 2.6 52.3 4.2 16.1 46.9 1.3 13.0 50.4 28.5 45.9 9.7 18.5 5.6 51.2 29.1 52.7 39.2 2.1 3.6 21.0 3.0 38.7 30.0 8.3 4.6 10.7 10.0 13.3 8.1 489.2 6.9 8.8 63.9 21.6 18.8 13.4 10.3 22.7 22.0 89.6 2.6 8.8 25.4 17.8 3.7 20.9 17.1 32.8 12.5 144.5 12.1 4.0 0.0 0.1 24.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 8.9 0.0 0.1 0.2 0.0 0.0 0.0 0.0 43.8 0.8 0.0 0.0 0.3 0.3 0.1 0.0 0.0 0.1 0.0 4.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 50.2 141.1 1.4 0.5 25.4 0.6 0.4 0.3 0.4 179.6 0.4 0.4 0.2 32.9 0.3 0.7 12.5 0.3 364.9 2.6 4.2 1.3 13.0 2.1 3.6 8.3 4.6 6.9 2.6 3.7 4.0 2.0 0.0 1.9 0.3 1.8 18.7 0.0 0.0 0.6 0.1 0.3 0.4 10.6 5.7 0.0 0.0 0.0 5.0 4.5 0.0 0.0 0.0 5.1 0.6 10.6 3.8 0.0 1.3 3.9 0.0 5.6 13.7 0.0 0.4 1.3 0.0 2.9 0.9 863.3 0.0 1.4 0.0 0.0 92.4 205.1 5.8 4.4 232.0 19.6 64.6 53.1 0.9 6.2 0.5 0.7 0.1 0.0 0.7 1.2 0.0 0.0 11.0 2.2 6.5 59.2 2.5 3.3 1.6 0.9 1.2 15.2 10.1 2.6 0.4 0.0 0.1 F13B FXIIIB ENSG00000143278 "Coagulation factor XIII B chain" P05160 1 197038741-197067260 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Blood coagulation, Hemostasis" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 211 "liver: 200.2" "Cell type enriched" "Detected in some" 26 "Hepatocytes: 54.9" "Cancer enriched" "Detected in single" 816 "liver cancer: 46.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA003827, HPA052139" Supported "Secreted to blood" NA NA 4700000000 "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 2: Hepatocytes - Metabolism" "HPA003827: AB_1078794, HPA052139: AB_2681744" "unprognostic (1.46e-1)" "prognostic favorable (6.78e-5)" "unprognostic (1.21e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 200.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 54.9 0.0 0.0 0.1 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 FAAH2 "AMDD, FAAH-2, FLJ31204, RP11-479E16.1" ENSG00000165591 "Fatty acid amide hydrolase 2" Q6GMR7 X 57286706-57489193 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lipid degradation, Lipid metabolism" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 75.7;Excitatory neurons: 110.2;Inhibitory neurons: 131.2;Oligodendrocyte precursor cells: 110.6;Oligodendrocytes: 105.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "T-reg: 16.7" "Lineage enriched" "Detected in many" 9 "T-cells: 16.7" "Cell line enhanced" "Detected in many" "CAPAN-2: 14.0;HDLM-2: 13.0;RPMI-8226: 26.6;U-266/70: 20.9;U-266/84: 11.4" NA NA "Cluster 35: T-regs - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 25: RPMI-8226 - Immune response" "Cluster 58: T-cells - T-cell receptor" "unprognostic (1.37e-1)" "unprognostic (1.78e-2)" "unprognostic (7.68e-2)" "unprognostic (2.29e-2)" "unprognostic (1.02e-1)" "unprognostic (4.51e-2)" "unprognostic (7.93e-3)" "unprognostic (4.47e-2)" "unprognostic (1.94e-1)" "prognostic favorable (5.99e-4)" "unprognostic (1.77e-1)" "unprognostic (2.03e-1)" "prognostic favorable (2.47e-13)" "unprognostic (9.16e-3)" "unprognostic (2.27e-1)" "prognostic favorable (2.66e-4)" "prognostic favorable (6.83e-5)" 0.8 1.6 1.1 1.6 0.8 0.4 6.8 3.3 1.0 3.6 0.9 3.2 3.0 1.3 4.4 4.9 6.1 1.7 0.3 0.7 2.6 7.2 10.5 3.2 2.6 1.2 1.3 0.4 15.1 13.4 6.7 0.8 1.2 7.3 4.0 7.0 7.1 4.1 0.1 9.6 3.0 0.3 0.5 0.7 4.6 0.1 2.2 7.3 4.8 0.2 7.0 3.4 3.4 0.9 3.4 0.3 0.1 0.2 0.1 0.1 3.1 0.0 0.1 0.0 0.0 2.4 14.0 0.1 4.0 0.0 0.0 0.6 1.1 2.5 0.0 13.0 6.9 0.4 3.1 1.0 0.0 1.5 0.0 0.0 4.2 0.0 0.0 0.1 0.0 1.4 1.6 6.3 0.0 1.4 0.8 0.0 2.4 2.9 0.0 0.0 2.4 26.6 8.1 4.5 2.4 0.1 0.2 3.9 0.0 5.7 3.9 0.1 0.0 0.0 0.3 0.0 0.2 20.9 11.4 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.7 0.0 5.0 1.8 8.0 3.4 0.0 0.5 7.7 0.9 0.3 0.9 0.0 1.2 16.7 1.6 1.1 0.8 3.3 1.0 0.7 2.6 1.2 1.3 1.2 0.5 2.2 0.9 0.2 3.2 7.8 75.7 4.0 2.7 12.1 19.0 15.4 4.4 6.0 4.2 0.3 4.3 14.9 5.5 18.8 5.5 0.2 4.2 9.8 11.9 0.0 12.6 1.1 0.4 13.2 0.0 110.2 14.1 2.5 1.1 15.8 12.2 0.0 0.9 1.1 11.3 0.7 1.7 131.2 5.4 26.4 0.0 0.3 0.0 0.6 0.6 3.6 45.0 0.6 1.2 0.0 110.6 105.3 11.9 3.8 0.4 14.4 7.4 4.8 5.6 25.1 11.8 0.0 0.5 1.0 0.0 0.0 7.1 6.7 5.6 16.7 0.3 4.0 9.2 FABP1 L-FABP ENSG00000163586 "Fatty acid binding protein 1" P07148 2 88122982-88128062 "Cancer-related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Transport "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 13 "intestine: 5501.2;liver: 13065.3" "Cell type enhanced" "Detected in some" "Distal enterocytes: 12424.2;Hepatocytes: 7459.2;Paneth cells: 3975.2;Proximal enterocytes: 15929.5" "Group enriched" "Detected in many" 14 "colorectal cancer: 175.1;liver cancer: 437.4" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "CACO-2: 122.1;Hep G2: 393.9" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB002305, HPA028275" Enhanced Approved Nucleoplasm,Cytosol NA NA 45000000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 45: Enterocytes - Digestion" "Nucleoplasm, Cytosol" "CAB002305: AB_563728, HPA028275: AB_10600909" "unprognostic (1.91e-1)" "unprognostic (7.91e-3)" "unprognostic (5.47e-2)" "unprognostic (1.96e-1)" "unprognostic (2.03e-2)" "unprognostic (2.35e-1)" "unprognostic (7.99e-2)" "unprognostic (8.92e-2)" "unprognostic (2.29e-1)" 6.7 0.8 0.6 160.2 0.6 0.0 10.7 0.5 1.8 0.7 0.4 5501.2 4751.8 13.0 0.0 2.6 3.9 0.5 0.8 0.6 0.7 727.6 13065.3 0.9 3.7 0.6 0.5 0.9 1.0 0.3 0.8 0.7 0.5 2.6 3416.4 0.1 0.5 8.4 0.9 0.5 4727.6 230.4 0.5 2.8 15.8 1.1 0.6 0.1 0.5 0.4 0.1 0.6 0.8 0.7 0.0 0.0 0.0 0.0 0.0 0.0 33.3 0.0 0.0 0.0 0.0 122.1 0.0 1.4 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 2.2 0.0 393.9 0.0 7.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.1 33.0 0.5 0.0 0.0 0.3 6.4 37.4 0.0 0.5 3.6 24.7 2.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.1 11.8 0.7 0.4 0.1 2.5 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.6 0.6 0.5 1.8 0.6 0.7 0.6 0.5 0.5 0.5 0.6 0.7 0.0 0.0 0.0 0.3 42.6 0.0 0.0 0.0 0.0 0.0 0.1 0.3 1.3 120.1 0.0 60.7 0.0 0.2 0.0 12424.2 156.5 0.0 0.0 0.0 0.0 7.5 261.9 149.7 0.1 0.0 1.2 0.1 2.6 0.0 129.2 0.0 105.3 7459.2 1.5 0.0 0.1 1061.1 0.0 166.0 0.0 0.0 0.0 8.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 3975.2 0.0 0.0 0.1 15929.5 2014.4 0.0 0.0 0.0 0.0 0.1 0.1 1.5 0.0 0.0 1.4 29.3 0.0 1708.4 0.0 FAM20B "GXK1, KIAA0475" ENSG00000116199 "FAM20B glycosaminoglycan xylosylkinase" O75063 1 179025804-179076567 "Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007409 Approved Supported "Nucleoplasm,Golgi apparatus" NA NA 14000000 "Cluster 21: B-cells - Adaptive immune response" "Cluster 38: Heart - Muscle contraction" "Cluster 1: K-562 - Erythropoiesis" "Cluster 6: Erythroid cells - Oxygen transport" "Golgi apparatus" Nucleoplasm "HPA007409: AB_10601649" "unprognostic (7.58e-2)" "unprognostic (1.12e-1)" "unprognostic (4.97e-2)" "unprognostic (6.23e-3)" "unprognostic (3.29e-1)" "unprognostic (3.07e-1)" "unprognostic (4.76e-2)" "unprognostic (7.70e-3)" "unprognostic (7.85e-2)" "unprognostic (3.93e-2)" "unprognostic (5.36e-2)" "unprognostic (1.58e-1)" "unprognostic (3.76e-1)" "unprognostic (2.03e-1)" "unprognostic (1.76e-1)" "unprognostic (3.67e-2)" "unprognostic (3.74e-1)" 20.9 22.4 15.0 11.2 17.2 11.7 15.9 12.7 17.1 16.1 7.7 22.2 9.9 18.0 15.4 17.6 15.4 13.6 23.4 18.0 17.2 17.3 16.5 16.3 11.3 14.0 14.6 19.9 11.4 21.4 14.4 17.0 14.5 16.5 14.4 28.7 11.8 19.4 19.6 12.8 11.5 19.4 13.5 12.4 13.6 8.0 15.3 11.5 17.9 25.6 10.8 16.2 12.3 14.7 41.4 37.1 28.2 30.0 49.1 51.4 31.2 33.7 38.3 23.2 20.7 18.7 40.1 21.3 43.2 59.7 19.1 29.3 29.0 24.8 33.8 27.3 19.5 67.9 34.8 23.9 24.5 45.5 41.1 30.1 26.5 31.7 24.5 35.4 29.0 29.2 77.0 30.2 37.5 23.1 19.9 16.4 37.1 46.2 7.9 24.1 29.7 28.4 19.5 46.1 37.5 91.8 35.5 39.7 34.5 39.8 34.4 32.8 30.8 36.7 32.2 51.1 46.0 24.5 48.5 18.2 36.5 21.7 37.3 0.9 0.6 0.2 1.3 0.6 1.3 1.4 0.7 1.1 0.8 1.5 1.1 1.0 0.6 1.6 0.8 1.2 1.0 0.5 15.0 17.2 12.7 17.1 18.0 17.2 14.0 14.6 14.5 13.5 15.3 14.7 16.8 6.4 11.4 16.0 7.5 15.6 12.6 8.9 4.6 15.7 12.2 9.3 40.1 12.8 9.0 18.4 25.0 9.0 9.0 10.6 3.9 8.8 5.2 8.8 17.8 13.8 14.4 43.3 28.3 13.0 7.7 14.6 9.2 14.5 17.1 20.2 9.3 14.2 7.6 38.7 32.0 7.9 10.2 11.6 8.1 5.1 17.7 9.6 16.0 19.7 14.1 9.0 2.1 17.6 32.5 13.7 3.8 21.4 6.2 19.7 5.0 5.9 8.8 21.0 13.1 20.0 17.7 17.6 13.8 9.6 12.9 7.5 8.0 24.1 8.5 24.7 FANCL "FAAP43, FLJ10335, PHF9, Pog" ENSG00000115392 "FA complementation group L" Q9NW38 2 58159243-58241372 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Fanconi anemia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocyte precursor cells: 81.4;Oligodendrocytes: 188.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033842, HPA036685, HPA036686" Supported Approved "Nuclear bodies,Vesicles" NA Yes "Cluster 19: B-cells - Humoral immune response" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Nuclear bodies" Vesicles "CAB033842: AB_1122766, HPA036685: AB_10672474, HPA036686: AB_10670844" "unprognostic (3.02e-1)" "unprognostic (5.52e-2)" "unprognostic (2.19e-1)" "unprognostic (2.02e-3)" "unprognostic (6.24e-2)" "unprognostic (2.92e-2)" "prognostic unfavorable (2.81e-7)" "unprognostic (4.71e-2)" "unprognostic (2.63e-2)" "unprognostic (1.31e-2)" "unprognostic (3.50e-1)" "unprognostic (1.17e-2)" "prognostic unfavorable (1.12e-7)" "unprognostic (1.50e-1)" "unprognostic (1.39e-1)" "unprognostic (9.08e-3)" "prognostic favorable (7.80e-5)" 8.5 35.3 39.4 11.0 49.5 15.1 19.5 35.3 39.4 18.6 27.2 12.1 11.5 19.9 18.4 11.5 13.9 12.0 13.0 34.1 45.1 12.2 21.7 9.6 14.8 51.6 40.3 24.8 14.5 14.0 44.3 12.5 55.4 14.7 14.8 24.6 18.7 10.7 9.1 17.9 12.8 13.5 40.9 16.8 13.1 19.1 41.2 13.2 17.1 9.1 12.6 11.7 14.6 68.6 48.6 35.0 69.4 34.0 11.9 15.1 36.9 34.8 21.5 33.8 43.5 30.9 59.4 33.4 43.8 11.4 46.3 27.5 39.0 26.4 56.0 78.8 61.7 54.8 49.5 42.1 13.0 53.3 29.0 11.8 12.4 24.8 9.7 29.9 27.0 23.5 51.9 29.6 23.2 24.6 18.9 65.8 75.2 77.4 7.2 35.2 52.5 26.1 29.9 47.2 78.1 39.3 49.5 20.2 33.8 37.0 18.7 35.4 15.9 30.0 45.0 22.3 39.0 30.4 20.6 19.7 63.7 35.7 46.6 3.2 3.0 4.9 3.7 5.6 3.0 9.1 3.2 4.2 5.9 9.3 1.0 2.3 0.8 7.6 4.3 5.3 4.8 2.2 39.4 49.5 35.3 39.4 34.1 45.1 51.6 40.3 55.4 40.9 41.2 68.6 16.7 19.2 20.0 18.6 9.4 10.3 13.9 26.1 11.4 16.6 12.5 15.4 16.4 8.6 16.1 9.2 4.2 29.1 4.8 7.2 11.7 9.7 2.5 11.1 15.8 14.8 9.0 14.5 45.0 4.2 14.0 12.2 15.3 6.2 10.8 25.8 13.2 12.5 10.9 8.4 38.4 15.0 30.5 6.3 4.6 3.6 10.8 7.0 26.6 34.7 6.8 22.8 3.1 81.4 188.9 4.6 13.3 14.3 9.7 6.2 21.7 5.7 23.2 18.7 13.1 10.8 12.4 52.6 37.9 9.5 6.8 7.4 5.6 13.2 16.0 9.3 FASTK FAST ENSG00000164896 "Fas activated serine/threonine kinase" Q14296 7 151076593-151080866 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Apoptosis "Kinase, RNA-binding, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031621, CAB032539" Approved Supported "Nuclear speckles,Mitochondria" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "Nuclear speckles" "CAB032539: AB_2101115, HPA031621: AB_10611966" "unprognostic (7.67e-2)" "unprognostic (6.41e-3)" "prognostic unfavorable (4.73e-4)" "unprognostic (2.60e-1)" "unprognostic (1.75e-3)" "unprognostic (2.03e-3)" "unprognostic (1.14e-3)" "unprognostic (1.01e-1)" "unprognostic (1.24e-1)" "unprognostic (4.66e-2)" "prognostic favorable (3.99e-4)" "unprognostic (3.49e-2)" "unprognostic (2.79e-2)" "unprognostic (4.12e-2)" "unprognostic (1.05e-1)" "unprognostic (1.09e-1)" "unprognostic (8.17e-2)" 23.4 36.5 35.5 13.4 33.8 8.2 21.7 32.3 50.6 23.5 30.1 31.5 26.2 23.3 11.9 39.5 21.1 14.5 66.9 34.8 32.9 34.9 58.0 18.8 14.4 34.2 33.9 24.6 28.1 31.0 41.2 9.4 34.5 34.1 11.8 7.9 27.8 18.8 122.6 28.2 25.0 11.8 33.1 24.8 29.0 21.8 35.7 14.7 26.9 95.3 10.5 26.7 25.1 34.3 39.3 45.0 13.9 34.9 50.4 22.4 22.8 29.9 40.1 25.3 29.7 31.5 34.9 9.2 41.0 40.9 46.9 24.1 13.5 36.4 6.1 26.9 23.8 11.4 12.7 27.8 62.7 9.0 25.2 29.8 51.8 29.4 21.5 20.9 30.0 22.4 17.0 20.2 29.2 80.4 20.4 23.5 24.6 47.8 50.8 13.2 17.4 30.4 34.2 27.8 16.4 18.2 40.3 62.5 43.0 11.5 34.4 31.2 24.0 32.7 7.5 31.7 28.0 50.5 33.0 6.5 66.2 19.0 39.8 18.0 31.5 30.1 22.3 32.5 23.4 19.5 23.4 23.4 28.4 21.6 25.5 21.9 6.8 20.4 32.5 38.2 28.3 21.9 35.5 33.8 32.3 50.6 34.8 32.9 34.2 33.9 34.5 33.1 35.7 34.3 21.2 0.0 7.0 17.9 34.3 24.6 37.8 68.8 23.3 42.9 31.7 26.9 18.9 30.0 43.6 25.8 25.0 49.2 38.2 59.2 86.1 49.4 10.0 22.5 21.3 22.9 44.9 28.2 12.7 47.6 26.8 33.8 54.6 24.8 38.8 38.6 23.6 37.1 43.3 37.0 13.6 54.9 59.0 26.3 22.5 20.2 36.4 25.8 94.3 7.5 35.3 54.7 44.3 9.5 10.7 38.6 40.0 34.3 46.1 27.7 86.6 66.3 24.9 51.1 13.1 33.7 35.0 58.5 70.7 36.0 25.3 60.5 34.8 50.1 61.2 35.0 FGGY FLJ10986 ENSG00000172456 "FGGY carbohydrate kinase domain containing" Q96C11 1 59296638-59810647 "Disease related genes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Amyotrophic lateral sclerosis, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 77.1" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 191.7;Cholangiocytes: 343.1;Hepatocytes: 142.3" "Cancer enhanced" "Detected in all" "liver cancer: 13.9" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HDLM-2: 42.9;RH-30: 28.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA054971, HPA075137" Approved "Nucleoplasm,Nuclear bodies" NA NA 220000 "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 44: HDLM-2 - Immune response" "Cluster 11: Alveolar cells - Smell perception" Nucleoplasm "Nuclear bodies" "HPA054971: , HPA075137: " "unprognostic (4.15e-1)" "unprognostic (1.87e-1)" "unprognostic (2.31e-2)" "unprognostic (2.80e-2)" "unprognostic (2.02e-1)" "unprognostic (2.20e-3)" "unprognostic (1.47e-3)" "unprognostic (1.80e-2)" "unprognostic (4.09e-1)" "unprognostic (2.78e-1)" "unprognostic (2.92e-1)" "unprognostic (1.47e-1)" "unprognostic (4.36e-3)" "unprognostic (7.22e-2)" "unprognostic (1.44e-1)" "unprognostic (2.70e-1)" "unprognostic (1.78e-1)" 4.2 14.6 10.5 2.0 12.8 2.3 6.6 21.8 10.2 6.3 4.5 7.1 7.1 4.7 36.5 5.5 9.9 5.4 11.3 7.4 12.1 19.1 77.1 4.7 3.3 12.9 13.4 4.8 12.0 10.5 9.7 3.0 12.9 7.8 6.7 9.6 7.5 10.3 41.8 5.7 8.1 4.2 9.3 2.8 6.1 4.2 16.5 4.1 7.7 17.1 3.6 7.0 5.2 12.7 4.8 1.4 9.2 3.9 4.7 16.6 0.8 4.1 6.8 2.3 3.4 0.0 3.8 5.4 13.0 11.0 4.1 2.0 1.6 11.9 4.9 42.9 1.1 3.8 2.9 8.6 12.3 2.3 2.4 23.2 10.2 5.0 7.9 10.0 4.6 6.0 2.7 3.4 15.3 5.2 3.0 3.2 5.8 13.0 5.3 6.5 28.3 2.1 12.9 8.8 7.2 3.2 5.6 3.3 12.0 8.0 2.8 2.3 4.7 4.0 2.6 4.7 2.8 7.5 2.9 4.6 12.9 9.2 3.8 1.5 1.3 1.4 3.0 1.3 2.7 5.1 1.4 3.8 2.2 3.6 2.7 4.3 2.2 2.9 3.4 1.1 2.8 1.8 10.5 12.8 21.8 10.2 7.4 12.1 12.9 13.4 12.9 9.3 16.5 12.7 3.7 54.5 191.7 83.2 7.9 20.9 23.8 45.2 14.2 10.1 33.1 66.9 29.9 343.1 40.4 12.9 12.5 9.3 3.7 4.2 17.6 62.6 14.0 33.2 7.5 6.9 2.4 12.2 20.4 42.5 4.5 7.6 7.1 20.4 10.1 5.3 5.3 142.3 11.4 8.4 33.7 11.3 22.4 8.8 7.6 11.4 1.8 6.7 35.6 17.8 11.2 12.2 3.1 39.2 36.0 17.7 7.7 3.0 3.4 19.1 14.9 47.9 91.2 16.4 0.0 31.4 8.9 4.6 11.5 13.5 31.5 4.5 5.1 5.9 17.1 35.5 FHIT "AP3Aase, FRA3B" ENSG00000189283 "Fragile histidine triad diadenosine triphosphatase" P49789 3 59747277-61251459 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Transcription, Transcription regulation" Hydrolase "Cancer-related genes, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "choroid plexus: 94.0" "Cell type enhanced" "Detected in many" "Astrocytes: 609.8;Inhibitory neurons: 450.5;Microglial cells: 337.3;Oligodendrocyte precursor cells: 1086.7;Oligodendrocytes: 1111.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 4 "naive CD4 T-cell: 87.6" "Lineage enriched" "Detected in all" 12 "T-cells: 87.6" "Cell line enhanced" "Detected in many" "RPMI-8226: 17.5;U-266/70: 34.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002684, HPA018840, HPA018909" Enhanced Approved "Nucleoli fibrillar center,Plasma membrane" NA NA 12000 "Cluster 32: T-cells - Unknown function" "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 29: U-266 - Adaptive immune response" "Cluster 68: Oligodendrocytes - Mixed function" "Nucleoli fibrillar center, Plasma membrane" "CAB002684: , HPA018840: AB_1848538, HPA018909: AB_1848537" "unprognostic (2.36e-3)" "unprognostic (6.38e-2)" "unprognostic (1.59e-1)" "unprognostic (4.42e-2)" "unprognostic (1.10e-1)" "unprognostic (1.08e-2)" "unprognostic (1.18e-1)" "unprognostic (3.16e-2)" "unprognostic (2.77e-2)" "unprognostic (8.49e-2)" "unprognostic (2.36e-1)" "unprognostic (6.77e-2)" "prognostic favorable (1.36e-4)" "unprognostic (1.54e-1)" "unprognostic (5.96e-2)" "unprognostic (1.29e-2)" "unprognostic (1.80e-2)" 5.6 24.4 13.7 6.2 18.3 8.0 9.0 13.0 17.3 5.4 94.0 6.9 6.4 3.5 6.9 5.0 6.6 9.8 15.8 19.7 16.4 24.9 9.6 4.7 7.6 18.9 17.0 6.8 13.0 18.1 7.9 3.0 18.9 5.3 5.8 7.6 8.5 4.7 10.6 8.1 5.3 4.7 15.0 5.0 8.6 5.5 15.9 12.1 11.7 7.2 5.3 6.7 4.2 19.8 0.1 0.0 1.4 0.0 0.6 0.1 2.5 0.1 0.2 0.1 0.0 2.7 4.2 4.0 0.7 0.1 3.0 0.0 12.7 3.2 0.0 2.2 5.0 3.3 2.0 6.4 3.3 8.7 0.1 9.1 5.2 0.2 6.9 0.3 0.0 3.7 2.5 11.9 0.2 3.6 15.2 6.7 1.2 12.2 0.9 11.3 0.0 17.5 15.3 2.0 2.9 4.3 1.5 9.9 10.1 5.3 0.4 0.2 0.0 1.7 0.4 0.1 2.4 34.6 11.3 0.0 4.0 0.1 1.9 6.8 4.6 0.5 2.2 2.9 1.4 4.1 17.2 1.8 5.7 3.1 87.6 15.6 0.8 7.2 1.3 5.8 20.5 11.9 13.7 18.3 13.0 17.3 19.7 16.4 18.9 17.0 18.9 15.0 15.9 19.8 4.1 6.4 10.6 609.8 19.7 7.6 20.7 30.0 46.7 12.6 41.2 31.2 10.0 38.6 17.5 27.6 58.4 42.0 12.4 6.9 78.2 19.1 45.8 14.6 7.9 7.0 7.7 17.7 276.6 4.7 8.5 10.1 18.3 19.0 5.7 25.7 14.6 23.4 20.9 30.3 450.5 12.9 22.4 10.2 7.1 163.0 19.3 12.9 12.4 337.3 8.6 19.7 6.2 1086.7 1111.0 9.7 15.0 9.8 23.8 12.0 20.7 126.6 12.4 20.7 0.0 10.7 6.2 19.1 7.5 33.7 11.2 32.7 11.5 23.0 20.1 18.8 FHL2 "DRAL, SLIM3" ENSG00000115641 "Four and a half LIM domains 2" Q14192 2 105357712-105438513 "Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 8 "heart muscle: 1421.4;ovary: 535.4" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 1077.5;Extravillous trophoblasts: 585.9;Granulosa cells: 851.4;Leydig cells: 567.0;Peritubular cells: 1049.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 5.7" "Group enriched" "Detected in many" 6 "granulocytes: 5.7;T-cells: 2.7" "Cell line enhanced" "Detected in many" "LHCN-M2: 534.6;RPTEC TERT1: 489.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005922, HPA006028, CAB008368" Enhanced Enhanced "Actin filaments,Focal adhesion sites" NA Yes 14000 "Cluster 18: Basophils - Vesicular transport" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 22: Epithelial cell types - Mixed function" "Actin filaments, Focal adhesion sites" "CAB008368: AB_591383, HPA005922: AB_1078860, HPA006028: AB_1078858" "unprognostic (1.04e-1)" "unprognostic (1.63e-3)" "unprognostic (3.30e-1)" "unprognostic (3.42e-2)" "unprognostic (5.89e-2)" "prognostic unfavorable (2.01e-4)" "unprognostic (2.80e-2)" "unprognostic (1.02e-3)" "unprognostic (1.81e-1)" "unprognostic (2.42e-2)" "unprognostic (3.34e-2)" "unprognostic (8.11e-2)" "prognostic unfavorable (6.42e-5)" "unprognostic (2.06e-1)" "unprognostic (3.49e-1)" "unprognostic (9.92e-3)" "unprognostic (4.73e-2)" 68.3 70.2 10.4 28.9 13.2 17.0 65.4 7.6 18.2 101.9 15.0 75.2 48.5 105.1 33.8 55.4 55.8 81.5 1421.4 18.9 7.4 55.2 22.1 17.5 17.2 6.7 7.2 535.4 9.1 8.2 29.3 79.3 7.0 88.8 56.8 8.5 45.3 63.8 67.5 44.2 50.4 91.5 7.5 20.1 94.9 50.9 7.9 22.8 41.3 118.6 13.9 105.5 47.2 12.2 156.8 36.1 20.9 0.8 65.2 81.7 196.4 289.3 75.9 182.2 216.7 65.6 237.6 0.4 23.7 353.6 223.8 47.7 31.4 262.4 204.2 6.5 23.9 108.7 42.9 49.0 257.6 0.4 23.5 171.7 142.2 286.0 188.1 360.8 374.4 18.0 29.0 8.9 534.6 5.6 25.8 1.0 44.1 108.3 113.2 0.4 31.6 4.3 489.8 108.4 1.0 6.9 109.2 48.1 76.9 20.5 60.7 3.9 183.1 130.4 134.1 146.4 236.0 3.3 0.6 0.7 208.1 0.6 138.5 5.7 0.4 0.4 1.1 0.2 0.7 0.6 0.9 2.0 0.4 0.5 0.7 1.5 2.2 0.7 0.2 0.6 2.7 1.5 10.4 13.2 7.6 18.2 18.9 7.4 6.7 7.2 7.0 7.5 7.9 12.2 15.7 9.6 5.1 0.7 1.0 468.5 1077.5 342.5 389.9 9.5 59.8 126.2 362.1 15.7 91.0 29.5 2.1 220.4 1.7 212.6 3.9 100.7 5.7 44.8 40.4 27.4 58.2 63.5 46.3 117.9 585.9 96.1 186.1 32.5 10.2 851.4 17.2 9.2 25.3 0.0 4.9 169.8 73.2 0.6 31.8 17.3 567.0 10.4 23.2 25.3 2.7 1.6 0.0 0.5 1.6 234.5 258.2 1049.0 6.7 198.2 51.7 28.1 19.1 13.0 216.9 60.6 171.0 9.1 17.7 124.5 296.9 178.7 7.7 193.5 55.8 536.2 FKBP10 "FKBP6, FKBP65, FLJ20683, FLJ22041, FLJ23833, hFKBP65" ENSG00000141756 "FKBP prolyl isomerase 10" Q96AY3 17 41812680-41823213 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Isomerase, Rotamase" "Disease variant, Osteogenesis imperfecta" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 79.1;Fibroblasts: 100.0;Sertoli cells: 59.2;Smooth muscle cells: 65.3;Theca cells: 54.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 551.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA051171, HPA057021" Enhanced Approved Mitochondria "Intracellular and membrane" NA NA 110000 "Cluster 22: NK-cells - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 33: Fibroblasts - ECM organization" Mitochondria "HPA051171: AB_2681371, HPA057021: AB_2683312" "unprognostic (8.30e-2)" "prognostic unfavorable (4.16e-4)" "unprognostic (9.05e-2)" "unprognostic (1.71e-2)" "unprognostic (4.77e-2)" "unprognostic (2.95e-2)" "unprognostic (1.14e-2)" "unprognostic (9.98e-2)" "unprognostic (2.21e-2)" "unprognostic (7.57e-2)" "unprognostic (1.14e-1)" "unprognostic (1.87e-1)" "prognostic unfavorable (0.00e+0)" "unprognostic (1.34e-2)" "unprognostic (5.77e-2)" "prognostic unfavorable (3.43e-5)" "prognostic unfavorable (4.99e-4)" 39.4 39.5 20.9 27.1 22.2 0.5 33.5 21.7 26.1 64.0 22.0 29.1 7.6 61.5 16.9 13.9 50.9 46.0 45.6 20.3 22.1 17.7 7.8 37.8 10.9 24.6 21.6 58.4 15.1 48.5 56.7 60.7 22.2 32.6 10.8 6.0 14.7 30.8 7.6 20.4 19.1 55.6 21.9 14.3 18.5 9.0 24.2 4.9 34.9 9.3 4.4 42.2 39.1 21.6 0.7 119.6 110.7 363.3 379.3 441.7 92.0 490.4 497.4 185.6 159.0 62.1 4.8 0.3 6.6 551.9 45.9 0.8 66.7 133.4 77.9 33.0 99.9 48.6 132.1 181.0 411.4 0.0 0.6 476.1 0.5 150.3 115.5 352.6 158.8 0.0 1.9 16.7 157.0 163.2 0.3 0.1 85.4 258.0 38.3 9.9 125.2 15.7 31.7 0.1 26.7 92.1 0.7 349.3 166.0 137.4 54.1 3.1 181.0 219.0 111.5 145.8 76.0 0.8 0.2 0.3 299.7 0.0 213.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 20.9 22.2 21.7 26.1 20.3 22.1 24.6 21.6 22.2 21.9 24.2 21.6 14.9 0.0 4.8 38.2 0.2 8.5 11.5 2.7 1.2 0.6 10.8 13.2 2.3 1.5 1.4 0.0 0.0 6.1 0.2 0.1 0.0 8.7 0.7 3.0 79.1 34.9 0.0 0.0 0.3 4.7 30.8 100.0 1.5 4.6 0.0 32.9 30.4 0.0 4.7 15.2 0.3 1.3 0.0 0.0 9.7 2.9 46.9 1.5 16.0 15.0 0.0 32.0 0.0 17.1 0.1 2.2 0.1 44.8 0.5 8.2 0.0 0.0 0.1 1.1 59.2 35.2 65.3 0.9 7.6 0.5 5.1 11.9 2.1 54.0 0.6 1.6 FKBP11 FKBP19 ENSG00000134285 "FKBP prolyl isomerase 11" Q9NYL4 12 48921518-48926474 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Isomerase, Rotamase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pancreas: 495.0" "Cell type enriched" "Detected in many" 4 "Plasma cells: 1153.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "MAIT T-cell: 188.3" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HHSteC: 332.6;Karpas-707: 315.1;OE19: 527.2" "Low region specificity" "Detected in all" HPA041709 Enhanced Approved Centrosome NA NA 170000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 21: OE19 - Mitochondria" "Cluster 55: Plasma cells - Humoral immune response" Centrosome "HPA041709: AB_10794487" "unprognostic (7.45e-3)" "unprognostic (8.62e-2)" "unprognostic (2.40e-1)" "prognostic favorable (7.09e-4)" "unprognostic (1.70e-2)" "unprognostic (2.00e-1)" "unprognostic (3.46e-2)" "unprognostic (1.75e-1)" "unprognostic (7.64e-2)" "unprognostic (3.49e-3)" "unprognostic (1.24e-1)" "unprognostic (1.46e-1)" "prognostic unfavorable (0.00e+0)" "unprognostic (2.15e-1)" "unprognostic (4.51e-1)" "unprognostic (2.79e-1)" "unprognostic (1.54e-1)" 25.6 17.6 4.0 60.2 4.1 34.5 34.5 3.7 4.9 42.4 5.6 57.2 70.8 17.4 86.4 16.2 19.1 25.4 13.1 3.8 12.0 13.8 59.4 23.9 55.4 5.7 6.3 13.8 495.0 4.7 47.2 15.6 5.2 28.9 53.3 2.1 160.2 32.7 2.4 8.0 55.9 26.2 3.8 76.4 70.6 6.1 9.6 16.4 22.9 0.4 77.4 49.2 17.3 4.8 13.6 24.7 3.0 4.5 116.0 141.3 3.8 123.2 183.3 128.0 154.5 78.3 88.3 192.8 2.2 226.8 1.1 60.6 31.6 60.4 77.0 39.1 7.7 6.6 24.7 0.3 332.6 3.2 3.3 165.0 109.8 99.2 171.4 67.2 75.4 53.1 3.0 315.1 49.9 44.7 26.3 5.1 7.4 527.2 33.9 76.5 3.3 280.7 21.0 2.3 35.0 10.6 36.6 66.5 24.4 4.0 2.0 7.0 49.2 21.0 2.8 2.1 2.3 132.3 122.2 108.1 16.1 3.9 33.0 6.0 1.0 2.8 115.7 1.3 188.3 50.5 80.5 92.7 1.9 25.7 38.8 69.9 4.1 26.7 1.1 39.3 33.4 36.3 4.0 4.1 3.7 4.9 3.8 12.0 5.7 6.3 5.2 3.8 9.6 4.8 22.3 16.0 19.1 5.2 229.8 28.3 56.0 48.6 39.3 5.5 45.0 43.3 2.3 30.0 42.8 9.2 39.6 21.5 130.9 23.1 7.9 23.7 18.4 19.2 117.8 32.3 25.1 20.6 5.3 171.7 80.7 64.1 31.6 31.0 12.7 34.0 40.4 96.6 10.9 1.7 3.7 227.7 16.2 15.1 26.1 17.4 27.7 10.1 272.1 0.0 8.0 1.8 158.6 1.5 1.8 59.8 14.3 13.9 1153.9 111.8 14.1 18.0 43.3 14.6 6.6 10.8 88.7 12.0 9.8 23.0 21.3 42.3 145.3 37.5 49.7 45.0 FKBP14 "FKBP22, FLJ20731" ENSG00000106080 "FKBP prolyl isomerase 14" Q9NWM8 7 30010587-30026702 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Isomerase, Rotamase" "Deafness, Ehlers-Danlos syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA013329, HPA026829" Uncertain Approved "Nucleoplasm,Golgi apparatus,Cytosol" "Intracellular and membrane" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 44: Endometrium - Transcription" Cytosol "Nucleoplasm, Golgi apparatus" "HPA013329: AB_1848613, HPA026829: AB_10601651" "prognostic unfavorable (1.60e-4)" "unprognostic (1.12e-3)" "unprognostic (6.84e-2)" "unprognostic (1.23e-2)" "unprognostic (2.36e-1)" "unprognostic (1.41e-3)" "prognostic unfavorable (6.87e-4)" "unprognostic (6.06e-2)" "unprognostic (7.00e-2)" "unprognostic (6.99e-2)" "unprognostic (2.05e-2)" "unprognostic (1.16e-1)" "unprognostic (1.93e-3)" "prognostic unfavorable (4.57e-4)" "unprognostic (1.15e-1)" "unprognostic (2.07e-3)" "prognostic unfavorable (4.25e-4)" 6.5 5.1 3.4 7.0 3.5 4.3 6.4 5.4 3.6 9.9 3.1 4.7 3.0 8.5 10.0 4.7 4.3 6.0 6.8 3.2 3.2 3.1 3.2 4.1 3.1 3.3 3.1 5.4 5.8 6.2 7.7 7.9 3.0 6.8 4.8 7.2 4.3 7.5 2.1 4.7 2.9 13.9 3.0 2.7 4.0 2.2 3.5 1.8 3.3 3.2 3.2 8.9 3.8 3.5 7.0 5.2 14.4 33.6 36.8 46.8 6.5 34.9 32.7 12.0 23.3 4.4 4.3 2.4 16.0 31.0 14.7 14.8 8.1 12.8 23.9 1.3 11.6 5.6 9.2 13.1 18.6 4.0 9.3 29.4 13.1 20.9 24.6 28.2 27.0 3.6 9.2 5.0 21.8 2.9 2.1 4.9 7.5 7.7 9.2 0.1 9.6 8.2 11.8 6.1 3.8 12.5 12.2 27.5 8.8 17.0 6.2 5.3 21.7 12.6 14.6 21.8 14.0 7.6 8.3 4.2 18.0 3.8 40.2 0.5 0.2 0.2 0.2 0.1 0.1 0.2 0.2 0.2 0.4 0.2 0.2 0.2 0.4 0.2 0.0 0.6 0.2 0.1 3.4 3.5 5.4 3.6 3.2 3.2 3.3 3.1 3.0 3.0 3.5 3.5 13.5 19.2 16.0 7.2 7.9 27.4 22.0 15.8 35.9 16.3 13.3 13.0 15.7 5.7 11.7 18.4 27.1 11.6 9.4 5.3 1.9 7.4 0.4 30.4 44.3 12.9 1.2 6.5 19.4 3.7 27.3 40.0 15.3 40.0 2.5 9.1 8.6 6.5 6.0 15.2 12.7 9.7 8.2 2.5 11.2 0.4 13.1 5.7 10.6 10.3 3.6 26.5 2.1 11.6 16.6 5.7 19.0 20.7 43.8 17.8 3.3 2.7 6.0 21.4 6.6 13.8 20.4 1.4 3.4 27.5 18.3 15.7 6.0 20.8 6.1 28.0 FKBP1A "FKBP-12, FKBP1, FKBP12, FKBP12C, PKC12, PPIASE" ENSG00000088832 "FKBP prolyl isomerase 1A" P62942 20 1368977-1393164 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Isomerase, Rotamase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Paneth cells: 977.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 5 "dendritic cells: 675.2;granulocytes: 974.2;monocytes: 1013.4" "Cell line enhanced" "Detected in all" "HUVEC TERT2: 1749.2;TIME: 1929.6" "CAB004639, HPA051798" Uncertain NA NA 12000000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 28: Placenta - Pregnancy" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "CAB004639: AB_425434, HPA051798: AB_2681615" "unprognostic (4.09e-2)" "unprognostic (2.29e-1)" "unprognostic (5.22e-3)" "unprognostic (1.28e-2)" "unprognostic (2.66e-1)" "unprognostic (7.18e-3)" "prognostic unfavorable (3.44e-7)" "unprognostic (7.05e-3)" "unprognostic (2.76e-1)" "unprognostic (8.81e-2)" "unprognostic (5.12e-3)" "unprognostic (6.65e-2)" "prognostic unfavorable (6.69e-5)" "unprognostic (1.97e-2)" "unprognostic (2.06e-1)" "unprognostic (1.21e-1)" "unprognostic (1.47e-1)" 272.7 185.0 138.4 178.8 177.5 167.0 188.2 88.5 163.2 123.0 112.6 158.6 108.9 165.4 150.1 169.8 131.7 104.5 171.4 166.7 115.8 186.7 98.1 235.2 162.7 92.4 98.9 135.1 114.6 123.0 79.5 218.7 95.6 125.4 188.5 11.8 111.0 119.8 110.3 127.3 117.0 225.1 97.8 185.7 118.3 56.9 120.5 188.1 190.9 150.6 202.2 206.8 126.2 118.9 718.1 299.5 172.9 240.3 654.1 771.3 202.9 423.9 337.1 382.7 354.2 278.4 295.2 272.5 149.3 555.7 656.3 337.7 255.1 1007.2 419.7 68.8 170.5 284.2 113.9 473.3 406.4 390.5 168.0 484.7 332.0 410.3 412.6 513.3 1749.2 401.0 271.0 145.8 443.3 125.8 401.9 453.7 307.1 335.3 276.4 307.0 254.1 351.9 540.0 243.4 248.7 173.8 208.0 479.3 728.8 231.8 177.2 293.0 1929.6 1363.6 201.8 278.1 329.5 76.4 168.1 292.9 248.1 332.3 307.5 316.3 870.8 974.2 112.9 1005.8 104.3 128.1 135.5 133.2 675.2 136.2 140.1 132.6 805.0 160.6 1013.4 312.7 195.0 1153.8 138.4 177.5 88.5 163.2 166.7 115.8 92.4 98.9 95.6 97.8 120.5 118.9 779.1 86.6 77.2 0.0 160.6 263.1 211.2 393.3 152.0 17.6 175.6 156.5 59.7 170.1 179.5 172.9 0.0 281.8 148.3 456.2 238.7 432.4 47.7 98.7 183.8 814.8 330.6 196.4 0.0 337.5 702.0 212.2 160.0 122.5 143.5 95.3 623.6 113.5 746.7 35.3 0.0 245.9 329.6 541.8 436.5 52.2 200.0 428.8 241.9 0.0 527.4 52.2 152.4 0.0 0.0 483.6 977.5 162.9 214.8 221.1 210.8 332.1 123.0 11.7 138.1 87.4 224.7 169.3 141.8 329.4 299.3 231.5 150.1 347.3 318.0 245.7 FKBP1B "FKBP12.6, FKBP1L, FKBP9, OTK4, PPIase" ENSG00000119782 "FKBP prolyl isomerase 1B" P68106 2 24049701-24063681 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Isomerase, Rotamase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 47.9" "Cell type enhanced" "Detected in many" "Pancreatic endocrine cells: 49.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "eosinophil: 2.2;T-reg: 2.8" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "Hep G2: 47.9;NTERA-2: 42.9;SH-SY5Y: 30.7;SuSa: 46.1;TIME: 38.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045572, HPA051798" Uncertain Approved Vesicles NA NA "Cluster 35: T-regs - Unknown function" "Cluster 65: Brain - Ion transport" "Cluster 5: NTERA-2 - Transcription" "Cluster 16: Pancreatic endocrine cells - Mixed function" Vesicles "HPA045572: AB_2732521, HPA051798: AB_2681615" "unprognostic (3.01e-3)" "unprognostic (3.35e-1)" "unprognostic (7.05e-2)" "unprognostic (9.89e-3)" "unprognostic (1.47e-2)" "unprognostic (2.10e-1)" "unprognostic (2.23e-2)" "unprognostic (9.19e-2)" "unprognostic (1.29e-1)" "unprognostic (2.90e-1)" "unprognostic (9.55e-2)" "unprognostic (1.08e-1)" "unprognostic (1.12e-1)" "unprognostic (7.53e-2)" "unprognostic (3.43e-2)" "unprognostic (2.85e-2)" "unprognostic (1.45e-1)" 5.6 4.4 32.5 2.2 36.1 1.6 5.5 26.5 47.9 6.7 23.0 7.1 19.6 4.8 2.7 8.3 3.9 5.4 5.1 39.2 30.9 8.7 6.6 10.5 1.5 27.7 27.6 5.5 7.5 7.0 6.4 4.0 30.3 7.2 3.3 7.7 6.6 6.3 1.4 6.5 6.8 2.7 25.9 2.8 15.0 1.6 32.7 1.6 6.7 1.2 2.3 5.6 8.1 30.5 0.2 2.0 17.2 0.0 10.9 4.7 6.2 5.8 6.0 2.5 3.6 1.2 2.0 0.0 4.3 10.3 15.4 6.8 25.7 20.2 1.6 3.0 16.1 6.0 0.2 47.9 4.5 0.0 14.1 3.9 4.6 5.9 1.1 14.7 16.5 6.8 1.5 0.1 5.9 0.2 2.0 0.0 42.9 1.7 3.0 3.1 1.5 0.2 2.0 1.3 4.1 30.7 0.3 0.1 5.8 46.1 1.2 2.2 38.0 0.0 5.2 0.2 1.4 1.1 0.5 0.0 6.4 0.0 1.3 0.4 0.4 2.2 0.1 0.4 0.0 0.1 0.2 0.2 1.0 1.2 0.0 0.1 0.0 0.1 0.0 0.2 2.8 0.5 32.5 36.1 26.5 47.9 39.2 30.9 27.7 27.6 30.3 25.9 32.7 30.5 9.3 0.0 6.8 2.9 1.8 9.2 14.0 13.7 11.4 2.1 6.5 13.7 0.9 22.8 4.7 7.3 0.0 4.9 2.7 15.8 13.7 27.6 0.6 3.5 5.0 10.9 9.5 7.0 16.9 38.2 31.9 6.9 16.3 7.1 1.3 3.4 15.7 10.2 7.5 1.7 7.8 8.9 2.0 4.0 17.4 2.9 2.8 9.1 28.4 4.7 13.0 31.4 1.0 2.5 1.3 49.8 25.4 4.1 2.4 15.5 10.6 6.8 2.0 3.6 26.3 2.9 10.6 1.6 5.4 9.1 7.4 5.2 4.9 1.4 4.5 19.3 FKBP2 "FKBP-13, FKBP13, PPIase" ENSG00000173486 "FKBP prolyl isomerase 2" P26885 11 64241003-64244132 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Isomerase, Rotamase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "plasmacytoid DC: 929.1" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025561, HPA049405" Enhanced Approved "Plasma membrane" "Intracellular and membrane" No No 510000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 68: Epididymis - Unknown function" "Cluster 25: RPMI-8226 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" "Plasma membrane" "CAB025561: , HPA049405: AB_2680749" "unprognostic (4.94e-2)" "unprognostic (1.12e-1)" "unprognostic (5.77e-2)" "unprognostic (2.66e-3)" "unprognostic (7.40e-2)" "unprognostic (1.92e-2)" "unprognostic (8.64e-2)" "unprognostic (1.62e-1)" "unprognostic (3.23e-1)" "unprognostic (5.91e-3)" "unprognostic (5.86e-2)" "unprognostic (7.18e-2)" "unprognostic (1.70e-2)" "unprognostic (1.58e-1)" "unprognostic (5.23e-1)" "unprognostic (2.30e-1)" "unprognostic (3.57e-2)" 64.7 127.6 185.1 77.5 187.6 50.1 58.3 192.7 234.7 113.1 210.8 105.7 136.3 81.1 397.7 68.4 94.4 77.2 117.4 185.0 196.9 122.7 197.3 62.7 70.7 199.9 199.6 75.3 280.1 160.4 200.9 73.1 197.7 92.5 84.2 37.1 208.9 146.7 33.3 60.9 107.3 72.6 183.4 67.5 113.4 74.7 194.3 59.0 187.6 48.4 70.4 85.7 61.6 196.0 101.2 144.8 82.8 165.9 178.5 98.2 94.6 132.9 146.4 108.8 101.4 148.1 257.0 80.8 195.4 186.5 148.2 134.7 70.5 121.0 51.3 101.4 54.5 90.0 196.5 158.3 231.6 74.5 125.5 116.0 169.3 145.4 163.5 156.9 86.9 76.6 61.0 253.6 138.1 186.7 85.1 112.6 92.6 211.1 130.0 70.8 70.9 299.2 198.9 120.7 110.0 91.3 85.4 263.2 147.9 59.5 98.1 69.5 68.9 123.8 100.9 182.8 72.6 128.5 48.6 69.0 156.7 80.6 142.8 276.8 173.1 25.9 178.9 191.2 230.8 170.1 139.2 176.4 172.2 165.0 90.4 131.5 68.6 162.9 162.7 929.1 55.9 126.7 185.1 187.6 192.7 234.7 185.0 196.9 199.9 199.6 197.7 183.4 194.3 196.0 129.5 147.4 168.0 20.9 179.7 164.4 251.0 447.2 125.2 86.4 205.0 185.4 134.7 275.9 270.6 389.9 22.9 279.8 174.4 534.1 412.8 270.8 126.4 212.5 206.3 138.6 342.6 41.4 11.3 254.2 386.9 167.0 179.4 258.5 144.0 146.5 148.5 754.4 228.4 32.0 14.8 508.2 305.2 100.1 201.7 99.0 230.2 140.7 300.6 16.9 151.7 181.7 111.2 11.1 20.6 292.2 424.7 255.1 765.2 315.5 594.7 792.2 241.9 83.3 184.1 138.4 221.3 327.1 282.1 136.6 168.1 620.5 123.6 138.8 339.4 312.0 FKBP3 "FKBP-25, FKBP25" ENSG00000100442 "FKBP prolyl isomerase 3" Q00688 14 45115599-45135319 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Isomerase, Rotamase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 424.4;tongue: 372.0" "Cell type enhanced" "Detected in all" "Late spermatids: 377.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000864, CAB012232, CAB012520" Supported Supported Cytosol NA NA 1300000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 80: Striated muscle - Unknown function" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 10: Non-specific - Unknown function" Cytosol "CAB012232: , CAB012520: AB_873554, HPA000864: AB_1078873" "unprognostic (7.77e-2)" "unprognostic (1.47e-1)" "unprognostic (3.18e-1)" "unprognostic (9.72e-2)" "unprognostic (1.25e-1)" "unprognostic (9.82e-3)" "unprognostic (3.58e-3)" "unprognostic (2.28e-1)" "unprognostic (5.04e-3)" "unprognostic (1.22e-3)" "unprognostic (7.47e-2)" "unprognostic (6.92e-3)" "unprognostic (1.00e-1)" "unprognostic (3.07e-1)" "unprognostic (1.51e-1)" "unprognostic (1.00e-2)" "unprognostic (1.47e-1)" 40.9 46.8 100.3 35.8 102.3 38.4 50.0 110.1 122.1 38.1 91.8 49.4 44.7 31.4 64.8 54.7 31.4 29.8 109.5 101.9 100.6 66.5 69.7 27.6 53.7 100.7 99.3 35.3 32.8 55.5 56.6 46.9 100.1 57.7 49.1 82.3 37.1 37.9 424.4 38.3 47.8 39.2 99.8 39.9 38.0 52.9 101.4 59.6 40.1 372.0 57.7 43.3 38.6 105.8 161.0 175.3 249.0 132.4 109.0 117.8 98.3 96.2 110.3 149.3 163.5 154.8 134.1 85.1 98.9 110.0 84.1 130.0 188.4 124.8 211.7 123.7 111.0 69.8 138.8 202.6 107.1 122.2 72.8 112.0 127.5 87.2 80.1 136.8 198.0 131.9 102.9 62.1 179.9 196.9 197.5 163.0 126.7 178.3 164.5 187.0 183.7 102.9 242.2 183.7 151.2 59.2 154.8 94.5 156.0 186.4 222.6 89.9 128.7 113.0 195.6 59.9 75.1 104.0 198.8 132.5 68.3 83.0 108.1 23.4 22.4 22.1 18.7 27.3 22.8 29.7 25.0 25.7 33.3 21.8 23.4 26.7 3.6 24.2 29.4 43.0 30.8 20.2 100.3 102.3 110.1 122.1 101.9 100.6 100.7 99.3 100.1 99.8 101.4 105.8 48.3 41.7 46.6 25.8 45.3 47.8 94.4 205.5 45.5 79.3 39.9 46.7 202.5 48.6 101.4 93.8 10.4 320.9 51.2 56.4 252.4 131.1 212.7 55.0 83.3 58.5 56.1 50.9 49.7 73.0 135.4 70.0 36.7 68.1 53.7 75.6 38.2 91.1 131.1 40.4 44.5 71.2 124.1 39.9 43.0 377.4 80.8 53.7 69.4 17.8 110.7 80.7 50.4 21.1 34.3 88.4 53.7 97.8 58.0 76.4 91.8 220.1 73.5 67.4 105.2 71.3 118.5 154.0 111.2 65.0 47.9 165.0 48.8 84.1 96.1 77.6 FKBP4 "FKBP52, FKBP59" ENSG00000004478 "FKBP prolyl isomerase 4" Q02790 12 2794970-2805423 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Chaperone, Isomerase, Rotamase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 4 "brain: 372.1" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006148, CAB017441, HPA062857" Supported Enhanced Nucleoplasm,Cytosol NA NA 480000 "Cluster 44: Non-specific - Transcription" "Cluster 65: Brain - Ion transport" "Cluster 5: NTERA-2 - Transcription" "Cluster 22: Epithelial cell types - Mixed function" Cytosol Nucleoplasm "CAB017441: AB_10618759, HPA006148: AB_1078875, HPA062857: AB_2684883" "unprognostic (1.46e-2)" "unprognostic (1.73e-2)" "unprognostic (1.31e-2)" "prognostic unfavorable (7.65e-4)" "unprognostic (1.97e-1)" "unprognostic (1.07e-1)" "prognostic unfavorable (6.12e-5)" "prognostic unfavorable (1.44e-4)" "unprognostic (3.43e-1)" "unprognostic (3.25e-2)" "unprognostic (1.72e-1)" "unprognostic (3.14e-1)" "unprognostic (3.89e-2)" "unprognostic (1.59e-2)" "unprognostic (1.76e-1)" "unprognostic (1.59e-1)" "unprognostic (2.22e-1)" 35.4 38.1 92.1 22.3 95.9 24.2 53.1 127.7 372.1 41.7 89.6 35.7 20.3 32.2 44.6 69.3 38.2 24.8 42.7 96.6 104.4 68.1 57.5 38.0 19.8 101.0 101.4 50.4 52.0 47.8 36.1 50.6 106.2 44.4 37.8 52.2 48.1 44.9 69.4 49.8 25.6 40.0 97.8 24.3 58.0 58.4 103.0 25.1 44.4 48.5 29.9 44.6 46.0 141.7 91.6 198.6 56.2 94.9 68.5 40.1 268.3 87.5 31.2 141.2 95.0 199.1 108.3 120.9 24.5 56.6 98.2 121.9 353.3 118.5 168.2 222.6 226.1 133.2 141.8 71.4 52.6 105.5 35.0 36.5 106.6 167.2 165.9 84.0 83.5 119.8 124.9 166.4 57.6 261.5 186.2 94.9 480.0 266.5 141.2 110.0 98.7 72.4 119.5 114.2 80.7 116.0 101.6 272.7 45.3 348.8 368.0 70.3 44.9 69.1 216.4 78.6 224.1 40.9 67.9 177.0 61.4 154.7 72.2 17.0 11.5 6.7 12.5 10.5 13.9 14.0 11.0 11.9 6.4 14.3 11.3 13.5 1.5 9.2 15.5 5.6 11.0 11.1 92.1 95.9 127.7 372.1 96.6 104.4 101.0 101.4 106.2 97.8 103.0 141.7 31.9 6.4 11.5 10.1 39.1 143.9 261.5 38.5 80.8 60.3 133.9 96.3 13.1 54.3 26.8 53.3 75.0 186.1 27.2 111.0 154.6 82.0 125.4 49.7 47.4 43.5 106.1 77.8 12.9 25.9 117.3 42.6 41.8 74.5 38.2 45.3 20.7 49.3 62.0 97.6 15.5 124.9 63.1 17.5 102.1 40.9 34.8 67.7 92.5 4.7 40.2 48.3 25.7 10.1 17.6 60.3 100.1 38.7 47.3 272.4 77.3 141.7 21.1 63.4 85.5 28.3 117.2 149.4 74.4 111.5 132.8 223.3 74.0 38.6 148.7 147.3 FKBP5 "FKBP51, FKBP54, P54, PPIase, Ptg-10" ENSG00000096060 "FKBP prolyl isomerase 5" Q13451 6 35573585-35728583 "Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Chaperone, Isomerase, Rotamase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 892.7;tongue: 925.1" "Cell type enhanced" "Detected in many" "Kupffer cells: 384.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC diff: 759.3;ASC TERT1: 468.5;HHSteC: 593.0;HSkMC: 718.3;hTCEpi: 368.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009315, HPA031092, HPA031093, HPA031095" Enhanced Enhanced Nucleoplasm No No 39000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 41: Macrophages - Immune response" Nucleoplasm "CAB009315: AB_2278350, HPA031092: AB_10600195, HPA031093: AB_10601748, HPA031095: AB_2673734" "unprognostic (2.09e-3)" "unprognostic (1.70e-1)" "unprognostic (1.44e-2)" "unprognostic (1.17e-2)" "unprognostic (1.02e-1)" "unprognostic (1.93e-1)" "unprognostic (4.72e-1)" "unprognostic (6.30e-3)" "unprognostic (3.70e-3)" "unprognostic (1.47e-1)" "unprognostic (1.69e-1)" "unprognostic (1.73e-1)" "unprognostic (7.48e-3)" "unprognostic (2.18e-3)" "unprognostic (8.31e-2)" "unprognostic (4.22e-2)" "unprognostic (6.90e-3)" 400.1 92.3 18.2 70.1 26.8 26.6 160.4 19.7 32.1 86.4 20.2 110.9 11.3 97.5 63.0 130.6 104.6 78.9 93.7 16.8 20.7 108.8 144.5 92.7 166.7 22.7 23.8 122.1 200.4 227.0 52.9 28.5 23.5 85.0 37.1 25.6 61.0 49.8 892.7 114.0 135.7 81.8 17.0 105.6 129.0 41.4 22.1 229.4 97.2 925.1 80.3 108.9 109.1 26.2 40.0 17.1 73.1 109.7 759.3 468.5 1.2 21.2 1.0 13.6 31.0 29.7 6.9 195.3 19.5 4.1 11.8 0.6 44.1 93.2 32.0 77.7 41.6 84.0 14.1 41.7 593.0 53.3 8.3 718.3 368.6 23.7 220.5 14.8 80.1 38.8 91.3 77.1 144.3 25.3 222.5 99.6 18.9 8.7 12.3 97.7 19.1 95.4 60.2 23.7 27.7 16.8 17.3 19.8 4.2 15.9 108.4 62.2 178.7 19.3 17.3 2.8 29.7 34.9 42.9 243.5 6.6 102.3 7.6 57.6 105.0 70.0 64.4 92.3 78.0 9.7 90.6 68.5 107.5 12.5 133.4 96.7 85.1 45.2 46.8 32.0 37.2 158.5 18.2 26.8 19.7 32.1 16.8 20.7 22.7 23.8 23.5 17.0 22.1 26.2 180.2 12.8 11.3 23.2 42.9 17.6 59.2 20.1 37.0 1.9 32.0 20.8 131.8 74.4 14.2 5.5 0.0 1.2 102.0 14.3 23.5 0.6 9.8 55.7 76.1 57.9 20.9 102.2 25.9 7.9 0.8 97.5 18.8 79.2 38.5 54.7 117.1 225.6 35.1 0.0 2.8 35.5 34.6 384.2 44.8 22.0 160.9 192.2 7.2 66.5 110.3 4.6 44.3 16.6 26.3 2.9 19.3 218.6 66.4 49.9 157.0 27.4 18.2 22.6 144.7 188.1 106.8 14.9 19.1 37.5 21.3 0.4 128.7 2.8 39.5 22.2 FKBP6 "FKBP36, PPIase" ENSG00000077800 "FKBP prolyl isomerase 6" O75344 7 73328161-73358637 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Differentiation, Meiosis, RNA-mediated gene silencing, Spermatogenesis" "Williams-Beuren syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 222 "testis: 58.5" "Group enriched" "Detected in some" 6 "Early spermatids: 68.5;Late spermatids: 92.4;Spermatocytes: 142.0;Spermatogonia: 37.2" "Cancer enriched" "Detected in single" 9 "testis cancer: 0.6" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA061109, HPA077010" Enhanced Approved Cytosol NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Cytosol "HPA061109: AB_2684430, HPA077010: " "unprognostic (5.07e-2)" "unprognostic (3.34e-2)" "unprognostic (1.56e-1)" "unprognostic (1.91e-1)" "unprognostic (1.05e-1)" "unprognostic (3.98e-2)" "unprognostic (8.72e-3)" "unprognostic (4.34e-2)" "unprognostic (1.51e-1)" "unprognostic (3.60e-1)" "unprognostic (4.29e-2)" "unprognostic (1.48e-1)" "unprognostic (6.20e-2)" "unprognostic (9.15e-2)" "unprognostic (2.47e-1)" "unprognostic (6.86e-2)" 0.0 0.1 0.0 0.1 0.1 0.2 0.0 0.1 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 58.5 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.2 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.2 0.0 0.1 0.1 0.2 0.0 0.5 0.0 0.0 0.1 0.2 0.6 0.0 0.6 0.0 0.3 0.5 1.5 1.5 0.0 0.0 0.0 0.1 0.0 0.0 0.2 68.5 5.2 0.3 0.2 0.0 0.0 0.3 0.2 0.0 0.2 0.0 1.0 0.0 0.2 0.4 0.2 0.3 0.0 0.3 0.0 2.0 1.3 0.0 92.4 3.1 0.3 0.0 0.0 0.0 0.5 0.0 0.0 1.1 0.2 0.0 1.2 0.0 0.0 0.0 0.1 12.6 0.5 0.0 0.3 0.1 142.0 37.2 0.0 0.0 0.1 0.1 0.0 0.0 0.2 FKBP7 FKBP23 ENSG00000079150 "FKBP prolyl isomerase 7" Q9Y680 2 178463664-178478600 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Isomerase, Rotamase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "ovary: 50.0" "Cell type enhanced" "Detected in many" "Early spermatids: 149.1;Endometrial stromal cells: 54.8;Fibroblasts: 67.6;Leydig cells: 64.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "ASC diff: 155.0;ASC TERT1: 96.7;fHDF/TERT166: 60.9;HSkMC: 64.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008707 Approved Supported Approved "Endoplasmic reticulum" "Intracellular and membrane" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 33: Fibroblasts - ECM organization" "Endoplasmic reticulum" "HPA008707: AB_1848624" "unprognostic (1.33e-1)" "unprognostic (1.89e-2)" "unprognostic (1.43e-1)" "unprognostic (1.67e-1)" "unprognostic (5.61e-2)" "unprognostic (1.44e-1)" "unprognostic (1.25e-1)" "unprognostic (1.48e-1)" "unprognostic (1.34e-2)" "unprognostic (1.83e-2)" "unprognostic (6.05e-2)" "unprognostic (8.96e-3)" "prognostic unfavorable (4.61e-6)" "unprognostic (3.50e-3)" "unprognostic (1.34e-2)" "unprognostic (4.19e-3)" "unprognostic (1.10e-1)" 9.3 5.4 1.5 3.9 1.6 1.4 11.9 2.6 2.8 23.1 1.5 8.3 2.8 27.8 11.3 5.9 15.1 15.4 12.3 1.6 1.8 5.2 8.3 7.8 2.9 1.6 1.5 50.0 2.8 2.7 5.0 13.0 1.5 9.3 6.2 2.1 5.0 13.3 3.8 4.2 4.4 19.2 1.2 3.0 5.4 4.4 1.5 2.5 6.6 6.5 2.8 11.6 10.2 2.1 0.2 1.9 18.5 27.8 155.0 96.7 1.7 33.3 55.0 5.9 19.0 0.3 1.9 5.4 7.3 60.9 5.5 0.3 7.1 2.8 10.3 4.5 3.9 5.7 7.3 5.5 23.7 3.5 3.8 64.7 1.4 24.0 3.4 44.2 19.8 6.6 2.5 3.4 25.2 0.3 6.1 6.0 3.6 3.5 2.9 7.8 31.9 7.7 8.4 0.6 9.7 32.0 7.0 0.2 6.2 12.7 0.5 6.8 18.2 11.0 6.8 12.8 3.2 6.3 7.2 2.6 19.9 8.7 24.3 0.0 0.4 0.0 1.0 0.7 1.2 1.1 0.9 0.7 2.6 0.7 0.9 1.0 0.0 0.6 0.0 2.1 1.1 0.4 1.5 1.6 2.6 2.8 1.6 1.8 1.6 1.5 1.5 1.2 1.5 2.1 16.2 6.4 4.1 2.9 5.4 7.0 9.3 19.6 7.4 4.2 6.7 13.6 16.1 2.8 5.2 7.3 0.0 7.6 2.7 0.7 1.9 10.9 149.1 3.4 54.8 19.3 1.2 4.2 1.6 8.4 22.4 67.6 4.1 3.5 14.0 19.0 15.7 11.9 5.8 5.0 3.7 5.6 14.2 4.4 13.6 27.1 64.0 3.8 17.8 4.7 1.6 4.2 1.0 7.1 4.2 3.9 0.7 48.5 10.3 3.4 0.4 3.7 2.1 3.6 6.6 31.1 37.7 8.5 5.1 3.7 5.8 5.1 5.5 30.4 3.1 4.1 FKBP8 "FKBP38, FKBPr38" ENSG00000105701 "FKBP prolyl isomerase 8" Q14318 19 18531751-18544077 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Host-virus interaction" "Isomerase, Rotamase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Erythroid cells: 719.1;Late spermatids: 1236.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "eosinophil: 93.4;neutrophil: 78.0" "Lineage enriched" "Detected in all" 5 "granulocytes: 93.4" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025346, HPA045177" Supported Supported "Endoplasmic reticulum,Mitochondria,Cytosol" NA NA 10000 "Cluster 52: Eosinophils - Transcription" "Cluster 43: Testis - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 25: Spermatids - Spermatogenesis" Mitochondria "Endoplasmic reticulum, Cytosol" "CAB025346: , HPA045177: AB_2679244" "unprognostic (1.61e-1)" "unprognostic (1.33e-1)" "prognostic unfavorable (1.24e-4)" "unprognostic (8.93e-2)" "unprognostic (2.73e-1)" "unprognostic (9.22e-2)" "unprognostic (2.54e-2)" "unprognostic (2.26e-1)" "unprognostic (2.10e-2)" "unprognostic (1.49e-1)" "prognostic favorable (7.76e-4)" "unprognostic (8.51e-2)" "unprognostic (1.61e-1)" "unprognostic (2.97e-1)" "unprognostic (6.89e-2)" "unprognostic (1.12e-2)" "unprognostic (2.32e-1)" 206.9 161.5 426.8 79.8 423.7 272.9 197.3 359.7 645.5 235.3 332.7 311.1 85.5 188.6 59.0 238.3 198.1 85.5 244.3 427.4 395.7 194.8 233.7 187.6 97.9 427.6 405.1 263.6 167.2 109.1 312.3 91.2 406.1 249.4 33.6 51.4 200.0 115.3 202.7 185.9 159.2 62.5 381.7 193.6 189.3 378.4 423.4 86.2 205.9 105.5 52.7 228.3 222.4 437.8 196.3 139.0 106.0 201.7 106.2 165.6 266.8 155.0 163.1 116.5 160.2 133.3 259.1 111.6 245.0 191.7 77.7 104.4 65.0 216.5 31.4 136.6 316.5 105.3 175.4 162.3 183.3 105.5 220.6 217.3 204.8 104.0 65.4 216.1 121.9 213.2 222.4 254.8 102.1 329.1 190.4 313.1 216.3 174.6 200.2 197.8 88.4 387.3 154.9 126.6 117.1 213.2 108.8 87.7 197.5 77.8 104.5 299.4 143.2 143.2 130.3 282.1 120.0 194.6 118.2 130.8 321.5 166.7 130.8 18.1 14.7 93.4 14.2 15.5 13.3 10.2 14.6 16.3 11.1 9.8 11.1 12.6 78.0 8.8 19.0 11.3 15.8 30.1 426.8 423.7 359.7 645.5 427.4 395.7 427.6 405.1 406.1 381.7 423.4 437.8 115.9 9.6 1.1 35.3 115.1 95.3 164.1 118.4 68.3 64.8 110.9 107.4 2.0 115.8 58.0 101.2 14.6 246.4 107.0 287.7 248.4 178.4 412.3 65.6 59.2 92.3 205.9 719.1 32.0 126.9 234.8 126.5 80.5 64.6 52.8 125.0 99.6 66.4 237.3 99.3 33.2 156.8 126.1 184.1 145.0 1236.4 203.8 152.1 202.7 8.4 221.9 149.0 183.4 12.5 32.8 166.9 283.4 165.5 127.2 139.4 339.3 290.4 51.9 56.4 98.6 95.7 129.9 193.5 212.4 96.5 117.9 312.9 145.0 121.7 158.3 158.0 FKBP9 "FKBP60, FKBP63" ENSG00000122642 "FKBP prolyl isomerase 9" O95302 7 32957404-33006930 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Isomerase, Rotamase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 108.6;Fibroblasts: 89.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 4.0" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 379.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012595, HPA055256" Approved Approved "Golgi apparatus,Vesicles,Mitochondria" "Intracellular and membrane" No No 63000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 82: Adipose tissue - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Golgi apparatus, Mitochondria" Vesicles "HPA012595: AB_1848629, HPA055256: AB_2682761" "unprognostic (1.23e-2)" "prognostic unfavorable (4.22e-4)" "unprognostic (6.94e-2)" "unprognostic (6.25e-3)" "prognostic unfavorable (5.80e-4)" "prognostic unfavorable (2.02e-4)" "prognostic unfavorable (8.69e-4)" "unprognostic (3.40e-2)" "unprognostic (9.59e-2)" "unprognostic (2.58e-1)" "unprognostic (3.63e-2)" "unprognostic (3.30e-2)" "unprognostic (1.36e-2)" "unprognostic (6.31e-2)" "unprognostic (1.97e-1)" "unprognostic (8.90e-3)" "prognostic unfavorable (7.02e-6)" 80.7 44.8 23.9 16.8 24.0 2.3 59.1 26.5 25.3 65.9 28.1 44.8 19.7 55.7 22.4 35.6 50.6 44.4 77.1 21.4 32.1 38.2 21.1 49.6 13.6 28.9 30.2 46.3 40.8 25.1 34.8 77.4 29.3 42.3 45.3 11.7 36.0 52.1 35.0 64.4 31.0 74.4 28.0 23.7 41.0 11.4 34.2 8.2 40.8 49.7 15.8 43.3 52.2 27.9 38.9 71.4 27.6 113.4 254.1 290.2 36.4 202.6 209.9 65.5 103.9 31.6 89.2 0.2 80.7 379.5 105.1 73.3 40.8 100.0 75.2 0.1 11.9 6.6 72.3 31.6 105.6 0.4 10.8 191.8 59.6 59.0 56.9 156.3 83.9 0.1 15.0 7.7 137.3 37.1 0.2 19.4 5.8 76.6 37.3 0.3 73.7 0.3 73.0 13.0 25.7 62.4 115.6 58.4 73.4 69.6 41.1 18.7 112.8 107.0 99.8 67.4 46.8 23.9 48.9 0.2 104.4 0.3 218.5 0.9 2.2 0.5 0.0 1.6 0.0 0.2 0.0 0.0 0.8 0.1 0.1 0.0 4.0 0.1 0.4 0.1 0.0 0.6 23.9 24.0 26.5 25.3 21.4 32.1 28.9 30.2 29.3 28.0 34.2 27.9 108.6 12.8 21.7 22.9 0.6 34.3 12.7 31.4 10.2 8.2 15.7 16.5 46.1 17.2 10.3 18.4 10.4 18.8 0.6 23.2 5.9 19.5 0.5 22.6 25.8 80.1 12.2 1.7 9.8 41.5 27.7 89.1 17.9 23.0 5.7 81.0 60.0 18.0 7.6 11.8 10.2 25.4 10.2 8.6 23.5 3.2 36.7 5.4 60.5 15.0 2.9 30.5 0.0 8.5 8.8 36.5 22.1 55.3 4.4 8.1 18.8 8.1 11.0 5.2 46.0 21.2 45.8 1.0 1.3 12.1 28.6 13.1 3.1 12.3 27.7 10.5 FMO1 ENSG00000010932 "Flavin containing dimethylaniline monoxygenase 1" Q01740 1 171248471-171285978 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Monooxygenase, Oxidoreductase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 10 "kidney: 199.0" "Group enriched" "Detected in many" 7 "Proximal enterocytes: 97.9;Proximal tubular cells: 196.9" "Cancer enriched" "Detected in many" 8 "renal cancer: 18.0" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 7 "HSkMC: 20.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA078132 Approved NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 7: Kidney - Transmembrane transport" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA078132: " "unprognostic (1.04e-1)" "unprognostic (1.05e-2)" "unprognostic (5.87e-2)" "unprognostic (1.34e-1)" "unprognostic (5.32e-3)" "unprognostic (1.89e-2)" "unprognostic (1.04e-1)" "unprognostic (4.04e-1)" "unprognostic (9.16e-2)" "unprognostic (9.03e-2)" "unprognostic (1.36e-2)" "unprognostic (2.23e-1)" "prognostic favorable (2.81e-4)" "unprognostic (6.49e-4)" "unprognostic (1.40e-1)" "unprognostic (3.58e-1)" "unprognostic (1.37e-1)" 5.1 5.6 0.1 0.5 0.1 0.0 10.0 0.1 0.3 6.3 0.3 0.4 0.1 3.1 0.1 3.5 4.2 5.2 0.7 0.1 0.1 199.0 2.9 1.5 0.4 0.1 0.1 5.0 2.4 1.1 1.8 2.3 0.1 0.4 0.2 0.0 5.4 0.7 0.1 10.4 20.2 4.2 0.1 0.0 0.9 1.6 0.1 7.4 2.3 0.8 10.8 2.5 1.7 0.1 0.0 0.0 0.0 0.0 2.7 1.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 20.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.3 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 5.0 0.0 0.0 0.3 3.0 3.2 0.5 0.0 12.5 0.0 0.5 1.1 10.0 2.8 0.0 3.7 0.0 0.3 0.0 0.0 13.7 0.0 0.7 0.0 0.1 1.1 0.0 0.0 0.1 0.0 0.1 18.7 0.0 0.0 0.0 3.2 0.0 0.3 0.4 0.0 0.1 2.9 0.0 0.0 0.0 1.5 10.8 0.9 1.8 0.0 0.0 0.0 0.0 0.0 0.2 0.0 3.8 2.6 0.0 0.1 97.9 196.9 0.0 0.0 6.6 0.5 4.7 0.0 0.1 1.4 2.3 0.8 1.0 2.6 1.4 0.1 FMO2 ENSG00000094963 "Flavin containing dimethylaniline monoxygenase 2" Q99518 1 171185249-171212686 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Monooxygenase, Oxidoreductase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 69.7;lung: 93.9" "Cell type enhanced" "Detected in many" "Adipocytes: 187.0;Alveolar cells type 1: 461.6;Club cells: 204.7;Fibroblasts: 98.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 57 "ASC diff: 30.6;ASC TERT1: 13.7;HSkMC: 37.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA028261 Approved NA NA "Cluster 82: Adipose tissue - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "HPA028261: AB_10601012" "unprognostic (1.85e-2)" "unprognostic (3.14e-2)" "unprognostic (7.44e-2)" "unprognostic (3.75e-2)" "unprognostic (2.80e-1)" "unprognostic (1.37e-2)" "unprognostic (1.66e-3)" "unprognostic (3.00e-2)" "unprognostic (2.74e-1)" "unprognostic (1.58e-2)" "unprognostic (1.16e-1)" "unprognostic (4.28e-1)" "unprognostic (1.53e-1)" "unprognostic (1.26e-3)" "unprognostic (3.47e-1)" "unprognostic (1.62e-1)" "unprognostic (3.83e-2)" 69.7 24.0 1.5 1.3 2.4 0.1 47.8 1.3 1.4 6.6 2.9 6.5 0.9 5.1 7.7 65.9 33.3 4.6 50.0 0.8 4.1 10.4 4.3 93.9 11.6 2.2 1.7 4.3 5.5 4.9 6.3 0.3 1.7 5.5 1.7 0.9 36.5 2.9 17.6 4.5 4.2 3.9 1.5 0.7 6.8 1.1 4.7 8.6 12.0 20.3 11.8 4.5 11.6 1.1 0.0 0.0 0.0 0.0 30.6 13.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 37.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 2.4 1.3 1.4 0.8 4.1 2.2 1.7 1.7 1.5 4.7 1.1 187.0 461.6 21.7 2.6 0.1 0.4 4.4 36.0 2.8 0.4 14.5 69.1 9.2 0.0 204.7 1.8 0.0 0.0 0.5 0.0 0.0 0.5 5.5 0.1 0.1 69.1 0.0 0.0 0.1 0.0 0.0 98.7 0.0 0.0 3.8 0.0 3.3 0.0 0.0 0.0 0.0 0.0 12.2 0.0 0.7 2.8 0.9 1.8 0.0 37.5 0.0 0.2 0.0 2.0 0.1 1.3 0.0 0.0 2.5 3.7 0.0 10.2 36.0 0.6 0.0 9.7 48.5 0.3 0.1 7.4 0.0 0.0 1.1 1.6 0.0 1.2 FMO3 FMOII ENSG00000007933 "Flavin containing dimethylaniline monoxygenase 3" P31513 1 171090901-171117819 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Monooxygenase, Oxidoreductase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 41 "liver: 1123.3" "Cell type enriched" "Detected in some" 13 "Hepatocytes: 412.3" "Cancer enriched" "Detected in many" 13 "liver cancer: 94.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "ASC diff: 34.6;ASC TERT1: 26.0" "Not detected" "Not detected" "Not detected" "Not detected" HPA013750 Enhanced NA NA "Cluster 62: Liver - Hemostasis" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 2: Hepatocytes - Metabolism" "HPA013750: AB_1848968" "unprognostic (1.87e-2)" "unprognostic (6.30e-2)" "unprognostic (1.00e-1)" "unprognostic (6.81e-3)" "unprognostic (2.64e-1)" "unprognostic (1.31e-3)" "prognostic favorable (3.46e-4)" "prognostic favorable (5.60e-5)" "unprognostic (2.95e-1)" "unprognostic (9.34e-2)" "unprognostic (3.02e-1)" "unprognostic (7.21e-2)" "prognostic unfavorable (1.13e-4)" "unprognostic (1.84e-1)" "unprognostic (2.59e-1)" "unprognostic (3.45e-1)" "unprognostic (7.27e-2)" 27.2 12.4 2.5 0.9 2.7 0.4 6.8 2.5 3.6 1.2 2.3 1.4 1.8 1.3 3.0 5.1 13.3 1.8 4.2 2.3 2.6 14.0 1123.3 18.7 4.9 5.0 2.7 0.3 4.5 4.2 4.3 0.2 3.1 1.1 0.7 0.1 5.1 0.4 4.6 4.3 2.2 1.6 4.0 0.4 3.9 0.5 2.8 1.4 2.6 3.1 9.1 1.0 0.9 2.6 0.0 0.0 0.0 0.0 34.6 26.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.4 0.0 7.2 0.0 0.0 0.0 0.6 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 2.7 2.5 3.6 2.3 2.6 5.0 2.7 3.1 4.0 2.8 2.6 2.7 12.8 0.5 0.0 0.7 0.4 0.4 2.7 0.0 0.0 0.1 0.3 0.4 7.2 17.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 2.2 0.0 4.7 0.0 29.5 0.0 0.0 0.0 12.2 0.0 0.0 0.0 0.0 6.8 412.3 0.0 0.0 0.0 0.0 4.1 9.5 0.8 0.0 0.3 0.1 1.8 1.0 0.0 0.5 0.0 7.1 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.2 22.7 0.2 6.6 1.3 6.3 0.4 0.1 0.4 0.4 0.0 0.8 0.2 0.0 0.1 FMO4 FMO2 ENSG00000076258 "Flavin containing dimethylaniline monoxygenase 4" P31512 1 171314183-171342084 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Monooxygenase, Oxidoreductase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "kidney: 48.6;liver: 61.3" "Cell type enhanced" "Detected in many" "Distal tubular cells: 29.4;Hepatocytes: 22.1;Oligodendrocytes: 18.5;Proximal enterocytes: 16.5;Proximal tubular cells: 49.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "EFO-21: 5.7;HSkMC: 6.6" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA049100, HPA072438" Approved Approved Vesicles,Cytosol NA NA "Cluster 35: T-regs - Unknown function" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Vesicles, Cytosol" "HPA049100: AB_2680629, HPA072438: " "unprognostic (1.83e-2)" "unprognostic (1.17e-1)" "unprognostic (6.18e-2)" "unprognostic (3.01e-2)" "unprognostic (8.27e-2)" "unprognostic (4.13e-1)" "prognostic favorable (1.09e-4)" "prognostic favorable (7.45e-4)" "unprognostic (3.12e-2)" "unprognostic (2.15e-1)" "unprognostic (5.99e-2)" "unprognostic (2.90e-1)" "prognostic favorable (6.96e-4)" "unprognostic (1.03e-1)" "unprognostic (1.69e-1)" "unprognostic (7.45e-3)" "unprognostic (1.95e-1)" 3.7 2.6 2.2 1.9 3.1 0.9 4.1 2.8 3.0 3.3 3.1 5.0 5.4 2.7 6.3 2.3 3.5 4.9 5.2 2.1 2.6 48.6 61.3 3.2 2.9 3.1 2.8 3.8 2.4 4.7 1.9 2.3 3.3 3.1 4.8 0.7 2.0 2.2 1.0 3.4 9.2 2.0 2.6 3.1 5.0 1.7 3.1 3.6 3.2 2.1 3.3 2.4 2.9 3.5 0.1 0.1 0.3 0.4 4.1 3.4 0.2 0.8 3.7 1.1 1.2 0.6 5.3 3.7 5.7 0.1 2.0 0.2 0.7 1.0 1.6 1.6 0.8 0.0 0.0 0.0 0.6 0.7 0.8 6.6 2.4 0.4 1.0 0.4 0.2 1.7 0.2 2.3 0.5 0.7 1.6 1.3 0.4 0.9 1.2 0.4 0.4 2.1 2.6 0.0 0.1 0.0 1.2 1.0 2.4 4.1 2.2 1.0 0.1 0.9 0.3 1.0 0.7 2.9 1.0 2.2 1.8 1.1 0.8 0.2 1.0 0.3 0.9 1.6 0.7 1.2 0.8 1.3 0.9 1.8 1.2 0.9 0.1 1.7 1.1 1.2 2.1 0.8 2.2 3.1 2.8 3.0 2.1 2.6 3.1 2.8 3.3 2.6 3.1 3.5 2.2 0.0 2.6 7.2 3.2 2.8 4.6 5.0 2.8 0.0 2.3 2.0 3.7 2.8 3.7 9.2 0.0 2.8 0.6 7.1 29.4 2.3 5.7 3.8 1.7 1.4 1.2 0.0 0.1 1.4 1.2 6.6 8.2 1.7 1.3 1.5 2.9 22.1 3.7 0.0 0.1 3.2 2.0 5.9 1.3 1.3 1.5 2.7 5.4 2.8 1.6 1.8 1.0 0.0 18.5 1.1 0.7 0.4 1.1 0.9 16.5 49.5 7.3 0.0 0.0 1.8 2.1 0.3 0.5 1.9 1.6 1.9 1.7 2.0 2.8 1.8 FMO5 ENSG00000131781 "Flavin containing dimethylaniline monoxygenase 5" P49326 1 147175351-147243050 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Monooxygenase, Oxidoreductase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "liver: 683.3" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 64.2;Cholangiocytes: 133.0;Hepatocytes: 265.4;Proximal enterocytes: 108.8;Proximal tubular cells: 69.2" "Cancer enriched" "Detected in many" 7 "liver cancer: 43.0" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in some" 4 "Hep G2: 41.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA012373 Enhanced Supported "Endoplasmic reticulum,Cytosol" NA NA "Cluster 37: B-cells - Transcription" "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" "Endoplasmic reticulum, Cytosol" "HPA012373: AB_1848975" "unprognostic (2.70e-1)" "unprognostic (1.28e-1)" "unprognostic (1.33e-1)" "unprognostic (2.06e-2)" "unprognostic (1.39e-1)" "unprognostic (3.96e-2)" "unprognostic (2.43e-2)" "unprognostic (2.94e-2)" "unprognostic (1.10e-1)" "unprognostic (1.85e-2)" "unprognostic (2.93e-1)" "unprognostic (1.13e-1)" "prognostic favorable (1.34e-6)" "unprognostic (3.77e-1)" "unprognostic (1.38e-1)" "unprognostic (1.85e-1)" "unprognostic (4.11e-2)" 3.1 5.7 2.0 5.1 2.9 2.0 46.1 3.9 2.8 7.8 0.5 41.3 71.3 2.8 6.9 1.2 3.6 15.8 3.1 2.1 2.4 51.5 683.3 27.1 4.0 4.2 2.9 4.1 48.1 68.3 6.7 2.4 4.8 9.7 46.6 0.9 32.7 4.0 0.8 11.6 73.9 3.5 3.2 4.0 120.1 5.2 3.1 1.1 2.0 1.4 2.5 3.9 1.5 5.6 0.1 1.1 0.6 0.1 2.8 0.8 0.9 0.7 0.5 0.3 0.8 0.7 2.4 0.4 0.8 0.8 0.2 0.4 0.0 0.0 0.0 1.4 0.2 1.6 0.1 41.7 0.9 1.4 9.0 1.3 0.2 0.4 0.0 0.4 0.6 0.2 0.1 0.1 1.5 1.4 0.2 0.7 2.8 5.3 0.8 0.4 0.5 0.4 3.4 0.6 0.5 0.3 0.9 2.8 1.3 1.3 2.1 10.4 1.1 0.0 0.3 0.9 0.0 0.3 0.0 0.3 1.1 0.5 0.3 7.0 12.9 4.1 2.0 5.9 0.3 4.7 0.5 0.6 5.4 8.5 0.3 1.3 1.3 1.2 1.8 2.5 1.6 3.9 2.0 2.9 3.9 2.8 2.1 2.4 4.2 2.9 4.8 3.2 3.1 5.6 2.8 9.6 64.2 11.1 6.4 1.7 3.9 0.9 1.8 2.0 17.5 6.7 1.9 133.0 10.4 14.7 0.0 1.5 1.7 60.8 7.9 7.5 7.7 2.5 1.8 2.7 6.7 4.8 8.2 5.9 1.1 2.9 24.5 6.1 5.7 9.8 5.0 265.4 4.0 3.3 6.4 34.4 4.1 10.0 2.3 4.5 2.8 4.6 28.4 10.3 5.3 0.2 4.1 10.1 17.5 7.0 29.0 1.5 0.4 5.6 108.8 69.2 18.1 1.3 0.0 2.2 1.0 5.9 0.9 1.3 1.6 1.4 2.6 6.6 20.7 6.4 FN3K ENSG00000167363 "Fructosamine 3 kinase" Q9H479 17 82735615-82751196 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 79.8" "Cell type enhanced" "Detected in many" "Distal tubular cells: 90.1;Proximal tubular cells: 167.2;Rod photoreceptor cells: 72.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HAP1: 34.3;Hep G2: 66.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA059151, HPA061358" Supported Approved Mitochondria NA NA 180000 "Cluster 35: Non-specific - Unknown function" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "HPA059151: AB_2683931, HPA061358: AB_2684490" "unprognostic (4.74e-2)" "unprognostic (9.19e-2)" "unprognostic (4.22e-2)" "prognostic favorable (1.10e-4)" "unprognostic (6.10e-2)" "unprognostic (1.39e-1)" "unprognostic (6.45e-2)" "unprognostic (9.86e-2)" "unprognostic (5.08e-2)" "unprognostic (2.61e-1)" "prognostic favorable (2.40e-4)" "unprognostic (6.66e-2)" "prognostic favorable (1.39e-6)" "unprognostic (2.68e-2)" "unprognostic (8.02e-2)" "unprognostic (4.77e-1)" "unprognostic (1.22e-2)" 14.4 47.3 47.4 2.9 64.3 12.0 8.4 64.4 56.6 10.4 36.8 15.5 22.4 9.4 7.0 4.6 12.5 6.9 47.5 46.5 54.3 49.6 48.1 7.8 2.4 63.3 56.8 22.3 18.1 21.9 22.4 5.3 62.7 12.5 9.5 13.8 28.5 12.1 23.5 5.3 14.5 6.6 49.4 4.6 17.4 5.2 55.6 1.0 10.2 10.9 2.3 8.8 7.9 79.8 1.3 16.1 4.4 23.2 6.9 5.7 2.9 2.9 2.2 5.4 2.7 21.0 3.3 0.2 3.9 2.6 4.5 0.6 34.3 2.5 2.0 1.0 2.4 12.5 12.9 66.2 18.8 0.3 10.1 4.9 9.0 2.1 0.0 5.7 10.6 1.0 22.4 0.6 1.1 1.8 0.2 0.2 2.9 7.6 13.0 2.1 0.3 0.1 11.5 4.5 7.0 22.7 5.3 1.2 15.8 3.8 15.4 4.5 2.5 0.4 1.6 5.6 4.3 1.2 0.3 0.1 0.4 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 47.4 64.3 64.4 56.6 46.5 54.3 63.3 56.8 62.7 49.4 55.6 79.8 3.9 3.2 2.0 8.8 1.9 1.5 3.7 1.5 14.8 41.9 4.5 3.7 5.8 4.3 2.5 31.3 47.9 11.7 2.6 5.7 90.1 3.2 0.2 11.6 3.0 5.2 5.4 49.2 10.2 1.2 2.6 8.6 47.9 25.9 1.3 6.9 4.2 5.4 8.2 32.0 13.0 10.4 6.1 1.0 3.4 0.4 5.3 5.7 12.4 5.6 1.2 36.2 1.0 6.0 17.1 1.7 7.3 3.0 9.1 3.9 28.2 167.2 2.5 72.9 0.0 6.1 9.8 0.8 4.1 12.8 1.8 8.3 3.1 18.6 9.5 3.5 FN3KRP "FLJ12171, FN3KL" ENSG00000141560 "Fructosamine 3 kinase related protein" Q9HA64 17 82716706-82730328 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 100.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA056172, HPA065831" Approved Approved Nucleoplasm NA NA 44000 "Cluster 41: Basophils - Cellular respiration" "Cluster 70: Brain - Nervous system development" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Nucleoplasm "HPA056172: AB_2683055, HPA065831: AB_2685565" "unprognostic (1.37e-1)" "unprognostic (4.95e-2)" "unprognostic (1.54e-2)" "unprognostic (2.09e-1)" "prognostic unfavorable (3.26e-4)" "unprognostic (2.31e-1)" "unprognostic (1.25e-2)" "unprognostic (8.67e-2)" "unprognostic (1.26e-1)" "unprognostic (1.99e-1)" "unprognostic (8.84e-2)" "unprognostic (4.32e-3)" "unprognostic (1.60e-2)" "unprognostic (1.31e-1)" "unprognostic (2.23e-2)" "unprognostic (3.97e-2)" "unprognostic (3.71e-2)" 23.2 22.1 40.6 13.3 43.7 18.8 19.7 43.3 41.3 23.4 35.1 22.9 15.3 23.1 19.4 20.4 20.4 16.6 16.1 41.1 41.7 23.9 29.3 16.3 18.5 42.5 41.6 32.1 19.3 18.4 17.2 21.8 43.2 20.8 18.0 17.8 22.2 23.2 11.4 23.6 19.4 22.1 42.9 20.9 20.6 13.7 41.7 16.6 16.7 10.6 22.8 19.7 20.7 48.3 31.4 122.3 33.6 44.5 15.9 30.3 27.2 56.9 31.8 54.5 44.3 64.9 21.8 25.6 37.0 46.6 50.5 35.3 30.1 43.5 48.7 17.2 54.3 42.6 66.2 77.5 28.3 30.7 23.2 27.8 50.9 51.7 28.1 33.4 39.8 35.9 42.5 15.8 70.7 59.8 58.8 45.2 15.2 68.7 53.5 44.0 83.4 40.3 38.9 58.7 27.6 58.1 93.7 42.7 47.3 57.4 69.8 43.6 34.8 103.3 35.9 74.2 85.3 32.1 37.8 64.8 48.1 38.2 49.0 32.0 21.9 30.6 29.6 24.7 29.5 23.9 28.8 28.8 18.2 24.8 32.5 24.3 3.4 32.1 13.8 36.0 29.7 26.0 40.6 43.7 43.3 41.3 41.1 41.7 42.5 41.6 43.2 42.9 41.7 48.3 14.3 12.8 11.1 5.5 13.9 15.0 26.0 26.0 15.4 18.1 13.3 15.6 6.9 25.8 15.3 11.0 8.4 100.3 20.0 12.2 23.5 20.6 2.0 10.7 13.0 14.8 7.8 31.2 7.6 11.1 45.3 18.1 13.3 22.3 13.3 18.6 10.8 12.1 33.8 3.3 6.7 15.4 22.4 11.2 11.3 4.2 28.3 12.8 23.2 6.5 20.9 36.1 17.5 5.0 11.8 17.8 15.9 31.6 27.6 15.5 11.1 28.2 10.0 18.5 13.1 13.6 20.9 18.3 36.2 18.0 15.3 62.5 17.2 22.3 15.6 24.0 GAK DNAJC26 ENSG00000178950 "Cyclin G associated kinase" O14976 4 849276-932373 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 134.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027405, HPA027459, HPA027463" Approved Supported "Golgi apparatus,Vesicles" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 24: NB-4 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "Golgi apparatus" Vesicles "HPA027405: AB_10611111, HPA027459: AB_10599948, HPA027463: AB_10601959" "unprognostic (1.55e-1)" "unprognostic (1.66e-1)" "unprognostic (2.46e-1)" "unprognostic (3.24e-3)" "unprognostic (1.07e-1)" "unprognostic (3.50e-3)" "unprognostic (1.68e-1)" "unprognostic (7.07e-2)" "unprognostic (1.39e-2)" "unprognostic (3.34e-1)" "unprognostic (3.03e-2)" "unprognostic (3.33e-3)" "prognostic favorable (1.70e-6)" "unprognostic (1.09e-3)" "unprognostic (1.79e-1)" "unprognostic (6.26e-2)" "prognostic favorable (7.41e-4)" 31.9 40.7 21.1 25.9 22.5 35.5 34.0 20.1 29.7 42.7 20.1 56.3 51.2 41.9 8.0 49.7 43.0 17.7 25.4 21.5 17.8 55.0 47.7 46.0 25.6 28.7 19.8 40.5 53.1 22.7 37.1 15.6 22.1 41.8 14.8 9.4 71.0 13.3 31.4 40.4 57.4 9.8 17.7 61.5 54.2 45.8 20.6 21.6 38.5 6.6 12.9 38.7 39.3 20.5 36.0 28.3 16.9 29.0 16.6 14.2 43.6 33.0 19.7 22.3 18.5 35.9 49.8 30.4 20.9 20.1 40.3 29.7 17.7 27.4 10.5 30.7 27.9 35.3 29.5 27.5 31.1 36.2 53.0 20.5 23.2 22.7 11.0 14.2 24.7 35.3 38.4 37.4 15.2 34.7 61.6 92.1 30.4 38.2 46.3 50.2 19.4 27.4 18.2 28.8 29.0 31.3 19.3 24.2 23.3 14.1 39.2 30.7 40.8 30.9 18.0 31.8 45.1 59.5 41.3 33.8 34.9 43.7 29.0 3.0 10.3 12.8 8.8 9.8 7.6 4.9 5.8 6.1 6.5 3.9 3.3 4.8 7.4 4.8 24.6 7.6 5.6 9.4 21.1 22.5 20.1 29.7 21.5 17.8 28.7 19.8 22.1 17.7 20.6 20.5 24.7 25.6 33.2 34.0 33.9 17.0 15.3 17.9 14.8 27.2 25.3 17.7 12.2 18.6 28.2 25.8 64.6 19.0 46.2 131.3 9.8 18.8 99.1 32.2 21.6 26.7 29.4 26.1 25.7 28.0 17.5 19.5 93.8 52.5 18.3 31.2 18.5 31.6 36.6 11.8 23.5 66.5 26.4 35.9 18.4 134.7 25.1 35.5 16.0 59.0 28.8 16.3 35.0 9.0 24.4 37.6 71.1 18.8 26.1 28.4 65.8 31.0 33.8 26.9 19.7 17.9 18.0 32.9 27.4 19.9 22.3 31.1 34.6 41.6 65.0 44.6 GDE1 MIR16 ENSG00000006007 "Glycerophosphodiester phosphodiesterase 1" Q9NZC3 16 19501693-19522123 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 270.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA077420 Approved "Nucleoplasm,Vesicles,Plasma membrane" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Vesicles "Nucleoplasm, Plasma membrane" "HPA077420: " "unprognostic (1.69e-1)" "unprognostic (5.13e-2)" "prognostic favorable (3.12e-4)" "unprognostic (1.47e-1)" "unprognostic (1.83e-1)" "unprognostic (4.10e-3)" "prognostic unfavorable (7.52e-5)" "unprognostic (2.10e-2)" "unprognostic (1.40e-2)" "unprognostic (4.31e-2)" "unprognostic (2.60e-3)" "unprognostic (9.92e-2)" "prognostic favorable (3.12e-5)" "unprognostic (8.36e-2)" "unprognostic (9.69e-3)" "unprognostic (1.88e-1)" "unprognostic (3.36e-2)" 28.9 25.9 42.9 15.6 46.3 27.8 21.1 42.9 49.9 21.9 40.4 44.9 30.0 20.0 27.5 22.4 16.9 18.4 52.8 45.7 45.5 27.6 25.4 29.3 11.7 44.5 47.7 12.8 28.5 76.8 19.2 20.5 43.3 26.7 41.6 19.8 28.3 30.3 62.9 26.4 27.7 26.5 42.8 13.5 34.3 14.1 48.8 16.8 20.3 64.4 15.3 30.2 16.6 47.4 38.6 46.2 25.0 29.4 115.3 43.3 34.7 38.3 66.9 30.0 37.1 26.6 67.4 29.2 48.1 57.2 32.8 31.8 35.2 46.6 36.9 31.7 52.8 24.2 41.4 57.2 69.1 32.7 21.5 44.9 73.1 32.2 37.4 54.5 40.6 36.3 13.7 29.1 33.2 70.3 28.3 29.1 29.1 59.9 34.2 40.2 45.7 41.7 72.9 59.7 28.9 25.8 37.0 44.5 37.9 38.5 45.8 37.8 42.7 25.3 22.3 33.9 24.6 27.0 27.4 19.9 38.5 47.2 23.1 52.0 19.3 11.2 8.9 17.7 11.5 7.2 10.4 10.4 12.4 6.1 5.5 8.5 34.0 6.6 22.7 7.5 12.7 8.2 42.9 46.3 42.9 49.9 45.7 45.5 44.5 47.7 43.3 42.8 48.8 47.4 12.2 38.5 86.8 7.2 18.9 23.5 30.3 56.2 22.8 15.4 38.3 22.4 66.8 34.3 56.0 9.2 27.1 80.4 23.2 123.1 23.5 97.0 35.1 26.9 23.8 17.7 33.5 100.8 12.0 163.9 78.6 27.3 24.5 21.5 3.8 36.4 20.7 23.9 60.8 32.0 15.9 57.5 61.1 48.2 22.9 61.2 28.6 32.3 24.9 8.4 38.2 22.3 24.7 9.5 25.0 77.4 97.6 38.0 19.6 100.5 101.7 45.9 39.7 29.6 13.1 16.7 24.9 87.1 59.6 31.9 29.5 270.4 22.0 45.9 85.3 79.2 GDPD2 "FLJ20207, GDE3, OBDPF" ENSG00000130055 "Glycerophosphodiester phosphodiesterase domain containing 2" Q9HCC8 X 70423031-70433390 "Enzymes, Metabolic proteins, Predicted membrane proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 20.8;lymphoid tissue: 59.2;skin 1: 47.8" "Group enriched" "Detected in some" 4 "Basal keratinocytes: 56.7;Distal enterocytes: 30.4;Muller glia cells: 29.9;Proximal enterocytes: 92.2" "Cancer enhanced" "Detected in many" "glioma: 10.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "AF22: 9.2;NTERA-2: 19.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 27: Brain & Skin - Unknown function" "Cluster 5: NTERA-2 - Transcription" "Cluster 45: Enterocytes - Digestion" "unprognostic (1.53e-3)" "unprognostic (5.79e-2)" "unprognostic (5.37e-2)" "unprognostic (5.00e-7)" "unprognostic (3.15e-3)" "unprognostic (3.65e-2)" "unprognostic (2.86e-2)" "unprognostic (4.66e-2)" "unprognostic (1.19e-1)" "unprognostic (8.40e-2)" "unprognostic (8.45e-2)" "unprognostic (1.06e-1)" "unprognostic (1.35e-2)" "unprognostic (5.41e-2)" "unprognostic (5.52e-2)" "unprognostic (2.22e-1)" "unprognostic (8.91e-2)" 0.0 0.0 10.4 0.5 9.8 0.1 0.9 7.6 10.3 0.0 8.9 4.8 11.1 0.0 4.9 0.2 0.2 0.2 0.7 8.5 11.0 0.5 0.0 0.0 0.0 9.4 14.4 0.1 0.0 0.0 3.2 0.1 10.4 0.0 3.9 3.6 1.0 0.3 0.5 47.8 20.8 0.1 9.0 59.2 1.8 0.0 12.4 0.0 0.0 0.0 0.0 0.7 0.1 10.8 0.0 0.0 9.2 0.0 0.0 0.0 1.8 0.1 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.1 2.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.3 0.0 0.2 19.8 0.7 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.6 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.1 0.2 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 10.4 9.8 7.6 10.3 8.5 11.0 9.4 14.4 10.4 9.0 12.4 10.8 0.0 0.0 0.0 12.7 0.0 56.7 0.0 0.6 0.0 0.2 0.0 0.0 1.9 0.0 0.2 0.0 0.0 7.0 0.0 30.4 0.0 0.0 0.0 0.3 0.0 0.2 1.2 0.0 0.0 0.0 3.5 0.2 3.1 0.4 0.0 0.0 0.0 0.0 0.4 0.0 0.1 3.7 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 29.9 0.0 0.0 0.1 0.1 2.3 0.0 0.0 0.0 92.2 0.0 0.1 0.9 0.0 0.0 0.1 0.0 0.0 0.0 12.1 3.3 0.2 0.0 3.1 0.2 GGT1 "CD224, D22S672, D22S732, GGT" ENSG00000100031 "Gamma-glutamyltransferase 1" P19440 22 24594811-24629005 "Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glutathione biosynthesis, Lipid metabolism" "Acyltransferase, Hydrolase, Protease, Transferase" "Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 174.8;liver: 115.7" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 80.1;Cholangiocytes: 48.6;Distal enterocytes: 54.1;Ductal cells: 82.6;Hepatocytes: 40.8;Proximal enterocytes: 111.7;Proximal tubular cells: 62.9" "Cancer enhanced" "Detected in all" "renal cancer: 37.2" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HDLM-2: 103.6;Karpas-707: 165.8;OE19: 169.5;RPMI-8226: 210.3;RPTEC TERT1: 203.2" "HPA045635, HPA047534, HPA065444" Supported Uncertain Vesicles "Intracellular and membrane" NA NA 3600000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 21: OE19 - Mitochondria" "Cluster 45: Enterocytes - Digestion" Vesicles "HPA045635: AB_2679400, HPA047534: AB_2680079, HPA065444: AB_2685491" "unprognostic (8.13e-3)" "unprognostic (4.76e-1)" "unprognostic (8.29e-2)" "unprognostic (1.28e-2)" "unprognostic (3.70e-2)" "unprognostic (1.43e-2)" "unprognostic (5.60e-3)" "unprognostic (1.68e-1)" "unprognostic (2.21e-1)" "prognostic favorable (7.44e-4)" "unprognostic (4.55e-2)" "unprognostic (2.55e-2)" "prognostic favorable (4.83e-4)" "unprognostic (1.44e-2)" "unprognostic (5.37e-2)" "unprognostic (1.74e-1)" "unprognostic (6.10e-2)" 3.3 2.4 5.5 6.4 6.7 12.0 24.7 7.0 7.5 28.7 5.1 20.3 84.7 3.0 72.0 3.3 3.3 47.1 7.2 5.1 5.1 174.8 115.7 42.6 5.4 7.2 6.6 3.2 63.1 0.2 5.5 2.4 7.8 48.8 11.0 1.6 9.9 21.6 1.9 4.1 80.4 2.2 5.9 13.3 31.3 18.4 7.1 6.5 15.9 0.4 6.2 5.7 4.3 9.2 1.0 79.7 1.0 0.3 0.0 0.5 2.2 0.5 1.7 0.8 1.0 11.7 18.3 1.0 16.2 0.1 14.8 11.0 6.2 0.8 0.5 103.6 12.3 0.6 40.8 64.3 5.5 1.5 33.2 2.1 0.9 2.5 1.7 1.4 0.5 19.0 8.4 165.8 1.0 1.7 1.6 52.4 6.4 169.5 0.7 0.7 6.8 210.3 203.2 2.9 0.5 1.2 0.4 33.3 0.8 22.2 32.4 39.6 6.4 10.6 9.3 46.6 0.9 48.2 18.4 0.7 19.0 58.7 0.5 4.8 12.3 0.2 1.0 6.0 2.9 2.2 5.0 2.4 6.5 0.2 0.6 1.4 15.9 4.9 4.0 0.1 6.5 5.6 5.5 6.7 7.0 7.5 5.1 5.1 7.2 6.6 7.8 5.9 7.1 9.2 0.2 80.1 22.8 3.3 2.8 0.8 0.1 0.3 4.6 0.5 5.9 2.3 0.7 48.6 4.9 1.8 0.0 1.4 0.7 54.1 1.9 82.6 1.8 1.2 0.6 0.7 1.2 5.3 4.4 8.1 0.4 3.9 15.3 5.1 5.7 0.1 1.8 40.8 4.9 0.0 4.1 4.4 4.1 2.5 1.7 6.7 0.0 2.9 1.8 1.0 5.8 2.5 0.0 1.5 5.7 20.9 20.1 0.4 12.8 2.0 111.7 62.9 1.6 0.1 0.0 0.1 1.0 0.6 0.8 0.4 0.4 0.8 4.0 0.0 6.5 0.1 GGT2 GGT ENSG00000133475 "Gamma-glutamyltransferase 2" P36268 22 21207973-21227637 "Metabolic proteins, Predicted membrane proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "kidney: 8.7;thyroid gland: 8.5" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 3.2;Alveolar cells type 2: 7.2;Early spermatids: 5.6;Late spermatids: 18.7;Proximal tubular cells: 3.4" "Cancer enhanced" "Detected in single" "thyroid cancer: 1.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HDLM-2: 1.6;HeLa: 3.5;Karpas-707: 1.3;U-2197: 8.9" "HPA045635, HPA047534, HPA065444" Supported Uncertain Vesicles NA NA "Cluster 7: Kidney - Transmembrane transport" "Cluster 18: U-2197 - ECM organization" "Cluster 11: Alveolar cells - Smell perception" Vesicles "HPA045635: AB_2679400, HPA047534: AB_2680079, HPA065444: AB_2685491" "unprognostic (4.27e-1)" "unprognostic (6.91e-2)" "unprognostic (7.03e-2)" "unprognostic (8.13e-2)" "unprognostic (1.01e-2)" "unprognostic (2.38e-5)" "unprognostic (1.05e-3)" "unprognostic (5.85e-4)" "unprognostic (7.97e-3)" "unprognostic (8.84e-2)" "unprognostic (1.16e-1)" "unprognostic (6.39e-2)" "unprognostic (2.39e-1)" "unprognostic (1.48e-2)" "unprognostic (3.46e-3)" 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.2 0.3 0.0 0.0 0.5 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 8.7 0.1 0.7 0.0 0.2 0.1 0.0 0.2 0.0 0.3 0.0 0.2 0.1 0.0 0.1 1.5 0.0 0.0 0.5 0.4 0.0 0.1 0.0 0.2 1.0 0.1 0.0 8.5 0.0 0.0 0.1 0.0 0.2 0.0 0.6 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.2 0.0 0.0 0.0 1.6 0.0 0.0 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.1 0.0 0.0 0.0 0.6 0.0 0.9 0.0 0.0 0.0 0.3 0.3 8.9 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.2 0.1 0.2 0.1 0.1 0.2 0.0 3.2 7.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.5 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 5.6 0.7 0.0 0.0 0.0 0.0 0.5 0.0 0.7 0.1 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 18.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.5 3.4 0.0 0.0 0.0 0.0 0.0 0.7 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 GGT5 "GGT-REL, GGTLA1" ENSG00000099998 "Gamma-glutamyltransferase 5" P36269 22 24219654-24245108 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glutathione biosynthesis, Leukotriene biosynthesis" "Acyltransferase, Hydrolase, Protease, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endothelial cells: 42.8;Fibroblasts: 58.3;Leydig cells: 36.4;Sertoli cells: 184.1;Smooth muscle cells: 85.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "basophil: 2.3;eosinophil: 4.5" "Lineage enriched" "Detected in single" 8 "granulocytes: 4.5" "Cell line enhanced" "Detected in many" "ASC diff: 164.9;ASC TERT1: 124.4;HHSteC: 234.7;HSkMC: 271.7;TIME: 110.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA008121, CAB032489" Uncertain Approved "Nucleoli fibrillar center" "Intracellular and membrane" NA NA 22000000 "Cluster 52: Eosinophils - Transcription" "Cluster 72: Non-specific - Transcription" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 48: Smooth muscle cells - ECM organization" "Nucleoli fibrillar center" "CAB032489: AB_2111010, HPA008121: AB_1078965" "unprognostic (8.14e-2)" "unprognostic (2.53e-1)" "unprognostic (5.66e-2)" "unprognostic (9.94e-2)" "unprognostic (8.13e-2)" "unprognostic (8.21e-2)" "unprognostic (2.33e-2)" "unprognostic (2.90e-1)" "unprognostic (1.81e-2)" "unprognostic (1.07e-1)" "unprognostic (8.37e-2)" "unprognostic (7.94e-2)" "prognostic unfavorable (6.36e-5)" "prognostic unfavorable (4.06e-4)" "prognostic unfavorable (6.97e-4)" "unprognostic (1.79e-1)" "unprognostic (8.33e-2)" 137.6 60.5 39.0 18.6 39.3 1.4 90.6 37.6 41.7 73.2 32.8 27.8 19.4 54.4 12.9 19.6 70.6 37.2 93.4 35.0 45.1 78.2 55.2 37.7 48.0 52.2 46.3 26.6 25.8 13.2 41.1 11.9 46.9 49.3 12.0 2.1 37.1 20.9 23.1 40.1 40.8 32.2 41.9 36.1 40.0 9.6 45.3 10.4 110.2 16.6 18.3 45.1 64.2 38.2 0.0 1.8 0.6 0.0 164.9 124.4 1.1 2.9 0.2 0.1 0.0 0.1 0.1 0.2 3.4 0.2 0.3 0.3 0.1 0.1 0.0 2.2 0.9 6.7 1.0 24.1 234.7 3.0 6.4 271.7 0.1 3.4 3.2 0.4 45.8 0.7 0.4 1.2 44.1 0.4 0.0 22.4 3.6 1.1 0.0 0.1 4.0 1.0 6.1 0.0 0.4 5.9 0.1 7.3 0.1 22.7 1.0 1.7 110.8 0.1 2.3 0.1 0.0 0.3 1.5 0.2 3.9 5.7 0.2 2.3 0.5 4.5 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.1 0.4 0.0 0.0 0.0 0.2 39.0 39.3 37.6 41.7 35.0 45.1 52.2 46.3 46.9 41.9 45.3 38.2 27.2 3.2 16.0 1.0 0.3 7.0 3.3 3.2 0.0 0.0 7.2 4.2 4.4 0.0 17.9 0.0 0.0 0.2 0.4 0.0 0.0 0.6 0.8 0.3 8.3 42.8 0.0 2.7 0.1 0.2 0.2 58.3 1.1 0.4 1.3 0.0 33.5 0.1 2.1 0.0 0.1 0.0 0.0 1.0 12.5 3.3 36.4 1.8 3.6 22.5 3.3 0.3 0.0 0.5 0.0 0.4 0.0 23.7 0.3 2.2 0.0 0.1 2.2 1.0 184.1 33.9 85.6 0.6 0.4 0.3 4.4 0.3 1.1 2.1 0.0 1.4 GGT6 FLJ90165 ENSG00000167741 "Gamma-glutamyltransferase 6" Q6P531 17 4556927-4560818 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glutathione biosynthesis" "Acyltransferase, Hydrolase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 53.8;intestine: 53.4;salivary gland: 55.8;skin 1: 56.2" "Cell type enhanced" "Detected in many" "Distal enterocytes: 208.5;Intestinal goblet cells: 69.4;Paneth cells: 135.8;Proximal enterocytes: 130.9;Undifferentiated cells: 86.1" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "RT4: 58.5;SK-BR-3: 19.4;T-47d: 60.5" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA023362, HPA027213" Approved NA NA 72000 "Cluster 6: Non-specific - Transcription" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 6: T47d - Mammary gland" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA023362: AB_1848955, HPA027213: AB_10601326" "unprognostic (2.23e-2)" "unprognostic (1.20e-2)" "unprognostic (2.14e-3)" "unprognostic (4.51e-2)" "unprognostic (9.71e-2)" "unprognostic (7.67e-3)" "unprognostic (1.29e-1)" "prognostic favorable (4.35e-4)" "unprognostic (2.10e-1)" "unprognostic (2.33e-1)" "unprognostic (3.07e-2)" "unprognostic (5.06e-2)" "prognostic favorable (9.42e-7)" "unprognostic (1.56e-1)" "unprognostic (5.71e-2)" "unprognostic (9.17e-2)" "unprognostic (8.07e-3)" 0.3 0.6 0.4 5.0 0.5 0.2 9.0 0.7 0.7 7.9 0.4 53.4 44.5 0.4 41.1 53.8 8.5 5.3 0.0 0.5 0.3 39.2 0.4 3.5 0.0 0.5 0.4 0.5 46.8 0.0 0.5 0.0 0.5 6.5 34.0 0.1 55.8 6.4 0.4 56.2 38.4 0.8 0.2 0.1 23.7 0.7 0.4 0.7 0.2 0.0 9.0 18.4 18.8 0.9 3.6 0.0 0.0 0.1 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 1.8 0.0 0.1 0.0 1.3 0.0 0.0 0.1 0.9 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 6.3 0.1 0.4 0.0 0.0 0.0 0.1 0.0 0.4 0.0 58.5 0.2 0.2 0.0 19.4 0.0 0.0 60.5 0.0 0.0 0.1 0.0 0.2 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.1 0.1 0.1 0.1 0.0 0.4 0.5 0.7 0.7 0.5 0.3 0.5 0.4 0.5 0.2 0.4 0.9 0.1 35.3 6.9 0.0 1.1 4.1 14.7 12.5 5.2 0.0 17.9 11.0 0.2 20.0 38.0 23.9 2.1 0.0 0.3 208.5 21.5 23.8 0.1 7.4 0.3 0.5 6.0 0.0 0.0 38.2 0.0 0.9 24.5 2.6 0.0 0.1 0.4 0.0 0.1 0.0 0.0 69.4 12.2 0.0 1.8 0.2 0.6 0.6 0.0 0.0 2.0 0.1 0.0 0.0 0.0 10.6 135.8 0.0 0.0 5.5 130.9 39.5 45.9 0.3 0.0 0.4 2.3 0.0 0.1 30.6 20.9 0.0 1.0 0.0 86.1 26.7 GGT7 "D20S101, dJ18C9.2, GGTL3, GGTL5" ENSG00000131067 "Gamma-glutamyltransferase 7" Q9UJ14 20 34844720-34872856 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glutathione biosynthesis" "Acyltransferase, Hydrolase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 60.9;Inhibitory neurons: 58.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA013204, HPA013339" Approved Approved Nucleoplasm,Vesicles NA NA 1900000 "Cluster 30: Non-specific - Translation" "Cluster 80: Striated muscle - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles Nucleoplasm "HPA013204: AB_1850347, HPA013339: AB_2668816" "unprognostic (1.32e-3)" "unprognostic (2.33e-1)" "unprognostic (9.31e-2)" "prognostic unfavorable (1.26e-5)" "unprognostic (1.27e-1)" "unprognostic (6.55e-2)" "unprognostic (1.46e-3)" "unprognostic (2.49e-2)" "unprognostic (3.49e-1)" "unprognostic (1.16e-2)" "unprognostic (3.34e-3)" "unprognostic (3.61e-2)" "unprognostic (5.00e-3)" "unprognostic (1.81e-1)" "unprognostic (1.63e-1)" "unprognostic (5.50e-2)" "unprognostic (2.00e-1)" 13.2 13.8 37.0 11.8 35.8 5.5 15.4 43.4 43.8 25.6 53.2 19.1 16.0 19.3 29.1 10.1 21.1 18.2 22.3 38.6 33.3 24.9 16.8 14.4 18.2 34.3 28.9 24.1 27.1 22.9 40.5 13.7 33.6 24.8 14.9 22.7 30.8 22.6 67.5 17.9 20.1 14.9 22.5 15.4 22.1 10.1 32.0 15.8 28.8 13.8 13.6 19.7 18.0 35.4 5.2 7.7 38.5 39.5 29.7 26.4 34.2 21.7 21.9 17.5 26.0 40.6 25.5 0.0 25.1 17.1 17.8 3.6 16.8 9.5 11.5 1.8 29.9 15.9 16.0 21.3 26.5 0.8 24.9 38.5 10.6 19.7 9.1 52.2 1.5 20.3 12.0 2.8 12.2 9.1 4.2 8.1 8.9 9.1 3.8 0.1 26.3 25.9 25.3 7.7 22.4 26.1 11.2 17.6 28.2 14.4 13.5 14.2 0.6 59.8 23.6 5.7 12.6 29.6 4.2 1.9 70.4 1.5 22.4 1.4 2.8 1.5 6.9 2.0 2.0 6.1 5.8 2.6 2.5 5.4 11.5 8.2 0.3 3.0 0.7 1.4 5.1 1.8 37.0 35.8 43.4 43.8 38.6 33.3 34.3 28.9 33.6 22.5 32.0 35.4 2.0 3.2 2.7 23.2 6.4 7.4 18.1 14.8 9.1 40.2 9.6 5.8 1.9 32.9 11.1 18.4 12.5 24.2 2.2 14.2 0.0 16.1 3.2 3.3 7.6 2.1 10.8 1.7 60.9 5.6 12.3 14.0 23.4 4.5 2.5 9.0 1.4 12.1 4.5 40.4 58.0 15.2 38.7 3.2 4.4 1.8 12.5 3.2 10.6 17.8 2.8 9.7 4.1 31.2 25.5 6.3 17.8 7.9 1.9 9.3 11.9 6.1 7.2 19.3 6.6 16.0 9.4 13.9 15.5 5.7 4.3 16.8 7.2 17.0 17.9 13.9 GGTLC2 GGTL4 ENSG00000100121 "Gamma-glutamyltransferase light chain 2" Q14390 22 22644475-22647903 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 19 "testis: 18.0" "Group enriched" "Detected in some" 14 "Alveolar cells type 1: 22.4;Early spermatids: 24.6;Late spermatids: 28.4;Spermatocytes: 14.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "RPMI-8226: 1.6;U-2 OS: 3.3" "HPA045635, HPA047534" Uncertain NA NA "Cluster 15: NK-cells - Transcription" "Cluster 83: Testis - Spermatogenesis" "Cluster 9: U-2 OS - Unknown function" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA045635: AB_2679400, HPA047534: AB_2680079" "unprognostic (2.58e-2)" "unprognostic (2.35e-2)" "unprognostic (7.17e-2)" "unprognostic (2.96e-1)" "unprognostic (4.31e-1)" "unprognostic (1.57e-2)" "unprognostic (1.06e-3)" "unprognostic (1.48e-2)" "unprognostic (1.55e-1)" 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.9 0.1 0.1 0.0 0.0 0.3 0.0 0.2 0.0 0.2 0.0 0.0 0.1 0.0 0.5 0.1 0.6 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.1 0.0 18.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 1.6 0.5 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.1 0.9 0.0 0.0 3.3 0.0 0.0 0.1 0.2 0.0 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.1 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.9 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.2 0.3 0.0 22.4 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 24.6 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 28.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.2 1.5 0.0 0.0 0.0 0.0 0.0 14.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GGTLC3 ENSG00000274252 "Gamma-glutamyltransferase light chain family member 3" B5MD39 22 18516344-18518161 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "kidney: 10.5;thyroid gland: 8.2" "Group enriched" "Detected in some" 10 "Alveolar cells type 1: 3.2;Early spermatids: 5.3;Late spermatids: 12.1;Spermatocytes: 5.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "SuSa: 1.5;U-2197: 1.0" "HPA045635, HPA047534" Uncertain NA NA "Cluster 7: Kidney - Transmembrane transport" "Cluster 12: NES - Nervous system development" "Cluster 25: Spermatids - Spermatogenesis" "HPA045635: AB_2679400, HPA047534: AB_2680079" "unprognostic (1.37e-1)" "unprognostic (2.06e-4)" 0.0 0.0 0.1 0.0 0.1 0.0 0.3 0.1 0.3 0.5 0.1 0.0 0.4 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.1 10.5 0.1 2.2 0.0 0.1 0.1 0.1 0.2 0.0 0.3 0.0 0.1 0.1 0.0 0.0 0.9 0.0 0.0 0.6 0.4 0.0 0.1 0.0 0.2 2.3 0.1 0.0 8.2 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.4 0.0 0.0 0.3 0.0 0.0 0.2 0.2 0.3 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.1 0.4 1.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.3 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.1 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 5.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GLB1 "EBP, ELNR1" ENSG00000170266 "Galactosidase beta 1" P16278 3 32996609-33097202 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Glycosidase, Hydrolase" "Disease variant, Gangliosidosis, Mucopolysaccharidosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "BEWO: 857.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008382, HPA040610, HPA069503" Enhanced Supported "Golgi apparatus,Vesicles" "Intracellular and membrane" NA NA 2700000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 28: BEWO - Transcription regulation" "Cluster 4: Macrophages - Innate immune response" Vesicles "Golgi apparatus" "CAB008382: AB_590642, HPA040610: AB_2677039, HPA069503: AB_2686142" "unprognostic (1.51e-2)" "unprognostic (3.66e-2)" "unprognostic (5.02e-3)" "unprognostic (9.66e-3)" "unprognostic (9.61e-3)" "unprognostic (1.04e-1)" "unprognostic (2.31e-3)" "unprognostic (1.32e-1)" "unprognostic (2.08e-1)" "unprognostic (1.16e-1)" "unprognostic (2.06e-1)" "unprognostic (2.08e-1)" "prognostic favorable (1.14e-5)" "unprognostic (3.05e-1)" "unprognostic (2.33e-1)" "unprognostic (2.20e-1)" "unprognostic (5.85e-2)" 22.0 36.1 12.1 27.8 13.0 21.9 20.5 12.5 14.8 33.4 16.0 43.5 43.0 21.9 103.6 15.4 28.2 32.0 15.5 12.5 14.8 46.0 48.2 42.7 25.8 14.3 12.9 21.4 30.8 59.4 18.5 53.8 15.4 23.2 45.6 14.9 25.3 29.3 7.7 15.8 31.0 30.6 12.4 24.4 35.5 13.5 13.5 17.5 52.8 10.8 23.0 31.8 16.2 15.1 37.4 63.6 39.8 48.3 241.9 123.7 857.2 59.1 157.6 73.7 95.1 91.3 86.5 17.9 50.9 120.9 53.9 35.1 38.1 75.5 53.7 104.9 33.0 69.9 35.3 47.4 124.3 50.5 69.9 144.9 70.2 67.0 39.2 144.1 116.5 24.7 64.3 67.0 81.8 44.6 29.6 31.6 26.4 78.0 27.0 24.7 26.4 86.6 78.4 54.4 12.0 40.3 75.0 120.2 74.4 69.3 80.3 130.2 67.7 46.8 32.2 65.2 50.1 53.2 87.9 5.9 99.6 71.2 36.7 43.9 146.2 86.4 29.2 125.8 40.4 37.9 34.3 31.8 166.5 35.6 17.9 21.8 56.6 26.0 92.1 35.1 77.1 91.9 12.1 13.0 12.5 14.8 12.5 14.8 14.3 12.9 15.4 12.4 13.5 15.1 8.7 19.2 25.3 39.2 18.6 6.0 13.6 60.1 10.8 11.3 11.5 7.5 9.1 34.3 43.3 27.6 6.2 100.1 14.1 41.9 27.4 53.5 24.8 18.7 16.0 17.4 16.9 20.6 46.7 35.4 55.3 29.2 26.0 27.1 26.6 20.6 19.6 39.7 79.5 5.0 46.0 23.5 40.7 43.9 13.9 5.0 15.2 41.7 14.2 23.4 64.6 16.5 10.3 27.2 24.2 28.1 43.4 21.1 19.8 9.9 36.2 33.1 31.0 16.2 13.1 12.9 16.3 1.0 6.6 10.1 3.4 49.1 18.7 51.0 32.0 12.1 GLB1L MGC10771 ENSG00000163521 "Galactosidase beta 1 like" Q6UWU2 2 219236598-219245478 "Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins" "Glycosidase, Hydrolase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 52.3" "Cell type enhanced" "Detected in many" "Early spermatids: 41.5;Spermatocytes: 117.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HHSteC: 19.7" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA043058 Enhanced "Secreted - unknown location" NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA043058: AB_10806375" "unprognostic (4.30e-2)" "unprognostic (6.93e-2)" "unprognostic (2.68e-2)" "unprognostic (2.08e-3)" "unprognostic (4.35e-2)" "unprognostic (1.51e-1)" "unprognostic (1.67e-3)" "unprognostic (3.32e-2)" "unprognostic (4.77e-1)" "unprognostic (2.39e-1)" "unprognostic (8.48e-3)" "unprognostic (3.27e-1)" "unprognostic (3.62e-1)" "unprognostic (1.28e-1)" "unprognostic (9.23e-3)" "unprognostic (1.33e-1)" "unprognostic (8.50e-2)" 4.6 4.8 3.1 4.0 3.4 4.5 5.3 3.3 3.0 5.3 14.7 3.1 3.1 5.9 11.4 2.5 23.1 9.0 2.2 3.0 3.7 13.6 3.1 5.3 3.0 5.5 7.0 7.1 3.1 14.4 6.8 8.5 4.5 5.6 3.7 8.0 4.5 4.8 0.9 4.6 4.1 5.8 4.4 4.9 2.8 52.3 3.7 3.4 8.4 1.0 3.4 5.9 2.1 5.6 2.8 4.8 7.4 5.9 8.0 9.8 3.7 4.6 9.7 5.7 5.3 1.9 7.7 0.9 4.1 4.1 4.3 1.5 1.9 4.6 4.5 2.6 3.6 2.9 6.9 4.5 19.7 1.1 4.4 11.4 2.9 5.4 3.3 13.5 5.3 4.3 1.8 5.3 5.4 4.0 2.5 2.7 1.3 1.0 1.3 2.5 4.1 4.0 11.5 1.6 4.7 4.2 3.9 5.3 4.3 4.9 8.4 2.6 4.1 4.7 5.8 2.8 2.6 5.0 1.7 1.5 8.8 1.2 12.3 1.9 5.1 0.3 0.7 6.4 0.4 0.4 0.5 0.7 2.1 1.0 1.1 0.7 2.1 1.0 5.4 0.9 0.2 1.7 3.1 3.4 3.3 3.0 3.0 3.7 5.5 7.0 4.5 4.4 3.7 5.6 3.2 3.2 5.1 3.3 1.3 1.8 2.6 3.6 0.6 4.7 4.9 5.6 1.9 1.5 6.3 3.7 12.5 3.4 1.9 1.1 3.9 3.8 41.5 15.7 3.9 4.2 4.9 1.3 0.9 1.8 2.2 8.4 1.1 2.2 0.0 2.7 8.6 1.3 14.5 3.3 1.1 3.2 2.0 5.6 2.4 25.6 10.8 4.4 8.8 1.9 2.7 5.0 3.1 1.0 0.5 2.1 3.3 6.4 1.8 2.7 6.5 16.5 23.9 10.2 6.6 3.8 2.2 117.4 9.7 1.8 1.7 1.4 2.0 7.0 2.4 1.7 GNPTAB "GNPTA, KIAA1208, MGC4170" ENSG00000111670 "N-acetylglucosamine-1-phosphate transferase subunits alpha and beta" Q3T906 12 101745499-101830959 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" Transferase "Cancer-related genes, Disease variant, Mucolipidosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "NK-cells: 192.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014558, HPA042343" Approved Supported "Golgi apparatus" NA NA 160000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 63: NK-cells & T-cells - Immune response" "Golgi apparatus" "HPA014558: AB_2732409, HPA042343: " "unprognostic (6.72e-2)" "unprognostic (1.66e-1)" "unprognostic (8.71e-3)" "prognostic favorable (8.48e-4)" "unprognostic (1.39e-1)" "unprognostic (8.37e-2)" "unprognostic (2.73e-1)" "unprognostic (8.57e-2)" "unprognostic (3.73e-2)" "unprognostic (1.09e-2)" "unprognostic (2.28e-2)" "unprognostic (2.00e-1)" "unprognostic (6.86e-2)" "unprognostic (3.44e-1)" "unprognostic (1.02e-1)" "unprognostic (5.44e-2)" "unprognostic (4.98e-2)" 11.9 7.9 18.8 16.2 22.2 23.9 16.4 14.4 20.0 17.4 2.7 29.6 14.2 11.8 6.2 15.6 8.8 14.8 21.5 22.7 10.8 14.5 9.4 27.0 20.6 8.5 11.1 7.2 11.3 23.0 8.4 14.8 9.7 20.1 30.3 13.0 54.3 13.0 16.4 25.1 16.2 15.9 8.9 19.0 21.3 10.4 12.4 34.1 13.9 25.9 17.8 19.3 12.0 13.3 18.2 17.5 6.4 10.9 52.3 24.8 19.6 25.4 52.3 24.7 32.2 13.5 12.4 38.1 17.9 35.1 20.1 23.2 29.8 32.8 38.4 18.1 15.6 16.3 15.4 19.3 9.7 15.0 31.7 19.3 17.7 23.5 13.8 61.4 44.0 30.0 25.9 11.0 23.4 27.8 45.6 21.0 22.0 22.6 12.5 10.6 32.6 51.2 39.5 46.8 13.6 11.2 42.3 29.7 60.7 23.5 30.6 9.8 43.6 23.1 12.5 19.6 14.4 30.0 32.9 21.5 26.4 21.8 14.6 8.6 3.8 4.4 18.8 3.6 6.2 3.0 4.0 10.3 7.1 4.9 5.1 7.9 1.4 17.0 4.6 6.9 3.3 3.7 18.8 22.2 14.4 20.0 22.7 10.8 8.5 11.1 9.7 8.9 12.4 13.3 25.3 60.9 65.0 35.9 42.1 16.8 32.9 16.2 17.1 23.6 25.2 18.9 43.5 18.6 27.8 22.0 25.0 25.7 107.3 68.3 7.9 10.3 0.6 25.3 23.7 21.1 18.0 19.5 84.5 15.1 15.0 18.9 33.1 61.6 122.8 24.6 10.4 9.7 46.7 8.4 83.8 29.6 24.4 46.7 17.6 3.8 17.1 41.2 42.7 30.0 43.5 26.9 192.6 135.2 19.8 15.7 129.3 12.8 63.9 28.1 17.7 13.8 10.0 37.0 0.0 18.6 14.9 12.4 33.0 26.7 14.3 8.8 63.4 30.6 49.7 46.5 GRHL1 "LBP-32, MGR, TFCP2L2" ENSG00000134317 "Grainyhead like transcription factor 1" Q9NZI5 2 9951693-10002277 "Metabolic proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Developmental protein, DNA-binding" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 119.6;skin 1: 87.7;vagina: 66.9" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 62.6;Cytotrophoblasts: 61.9;Extravillous trophoblasts: 80.5;Suprabasal keratinocytes: 132.7;Syncytiotrophoblasts: 184.6;Urothelial cells: 104.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in single" "eosinophil: 2.2" "Lineage enriched" "Detected in single" 8 "granulocytes: 2.2" "Cell line enhanced" "Detected in many" "BEWO: 212.3;RT4: 41.4;SK-BR-3: 112.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA005798, HPA006420" Enhanced Supported Nucleoplasm,Vesicles NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 28: BEWO - Transcription regulation" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Nucleoplasm Vesicles "HPA005798: AB_1079026, HPA006420: AB_1079025" "unprognostic (2.26e-3)" "unprognostic (5.80e-2)" "unprognostic (8.35e-2)" "unprognostic (7.33e-3)" "unprognostic (2.70e-1)" "unprognostic (2.76e-2)" "unprognostic (4.43e-3)" "unprognostic (6.73e-2)" "unprognostic (1.68e-1)" "unprognostic (1.00e-1)" "unprognostic (8.83e-2)" "unprognostic (1.68e-1)" "unprognostic (1.14e-4)" "unprognostic (3.66e-1)" "unprognostic (3.40e-1)" "unprognostic (4.04e-2)" "unprognostic (2.14e-1)" 4.5 1.3 2.2 1.2 2.3 8.7 39.8 0.8 2.8 31.0 1.0 1.5 1.2 1.0 7.3 119.6 2.2 3.0 2.5 2.7 2.5 4.0 12.2 5.0 1.0 0.8 1.5 0.4 4.2 29.0 3.6 26.7 0.9 11.4 1.0 11.4 44.7 7.3 1.1 87.7 0.7 0.7 0.6 0.8 3.7 3.2 4.3 0.9 2.9 0.4 26.1 13.9 66.9 1.7 10.9 0.2 1.2 3.0 0.4 0.5 212.3 1.0 1.5 0.7 1.2 0.9 7.5 1.4 0.4 0.1 1.5 6.5 13.0 1.4 3.1 3.2 5.9 0.3 2.3 4.3 0.3 0.7 1.2 0.4 5.5 6.0 0.0 0.0 1.1 2.3 2.2 4.1 0.0 14.3 2.2 1.7 0.8 3.5 2.5 0.9 1.0 1.9 1.4 41.4 2.4 1.6 2.0 112.3 2.7 17.4 13.7 0.4 1.2 0.6 2.6 3.3 1.3 2.7 1.7 1.5 0.6 1.7 1.8 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.2 0.0 0.0 0.2 1.7 2.2 2.3 0.8 2.8 2.7 2.5 0.8 1.5 0.9 0.6 4.3 1.7 2.2 3.2 8.1 3.9 1.2 40.0 23.1 10.7 2.8 25.5 37.1 19.9 2.1 1.5 31.1 20.2 62.6 61.9 1.3 1.2 0.0 2.9 6.4 4.5 1.3 4.2 3.5 0.0 14.6 9.1 80.5 5.4 3.1 9.6 10.2 0.4 2.5 7.7 7.7 11.8 6.0 0.8 4.1 1.0 15.7 3.0 0.0 10.6 21.4 1.9 1.0 1.1 0.0 4.0 1.0 5.7 0.1 0.4 1.0 31.5 0.1 2.4 18.6 11.5 0.0 3.0 3.7 9.6 5.1 35.2 132.7 184.6 2.1 0.1 1.2 104.6 GRK1 "GPRK1, RHOK, RK" ENSG00000185974 "G protein-coupled receptor kinase 1" Q15835 13 113667219-113737736 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Sensory transduction, Vision" "Kinase, Serine/threonine-protein kinase, Transferase" "Congenital stationary night blindness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 50 "retina: 42.6" "Group enriched" "Detected in some" 16 "Cone photoreceptor cells: 56.3;Rod photoreceptor cells: 84.9" "Cancer enriched" "Detected in single" 5 "thyroid cancer: 0.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA035200, HPA059376" Enhanced NA NA "Cluster 79: Retina - Phototransduction" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA035200: AB_2674515, HPA059376: AB_2683996" "unprognostic (7.93e-2)" "unprognostic (2.50e-1)" "unprognostic (1.87e-1)" "unprognostic (1.24e-5)" "unprognostic (1.76e-3)" "unprognostic (1.53e-1)" "unprognostic (3.59e-2)" "unprognostic (2.21e-2)" "unprognostic (1.84e-3)" "unprognostic (2.00e-2)" "unprognostic (4.02e-2)" "unprognostic (6.91e-2)" "unprognostic (6.18e-2)" "unprognostic (6.11e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 42.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.6 0.0 0.0 0.0 56.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 4.4 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 84.9 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GRK2 "ADRBK1, BARK1" ENSG00000173020 "G protein-coupled receptor kinase 2" P25098 11 67266473-67286556 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 197.1" "Cell type enhanced" "Detected in many" "Adipocytes: 33.4;dendritic cells: 80.2;Hofbauer cells: 35.8;Macrophages: 37.6;Pancreatic endocrine cells: 32.4;T-cells: 31.0;Theca cells: 36.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "NB-4: 318.0;REH: 417.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005021, CAB037248, HPA060707" Enhanced Approved Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 2: Immune cells - Immune response" "Cluster 14: REH - Unknown function" "Cluster 7: Non-specific - Mitochondria" Cytosol "CAB005021: AB_562360, CAB037248: AB_1078280, HPA060707: " "unprognostic (5.58e-2)" "unprognostic (1.75e-1)" "unprognostic (2.01e-2)" "unprognostic (5.33e-2)" "unprognostic (1.38e-1)" "unprognostic (1.29e-3)" "unprognostic (3.31e-2)" "unprognostic (6.17e-2)" "unprognostic (1.11e-1)" "unprognostic (6.35e-2)" "unprognostic (2.22e-1)" "unprognostic (2.55e-2)" "prognostic unfavorable (1.25e-4)" "unprognostic (3.66e-1)" "unprognostic (2.40e-1)" "unprognostic (4.04e-2)" "unprognostic (5.19e-3)" 41.2 35.6 42.4 73.0 42.7 197.1 38.0 31.6 63.8 41.3 16.9 54.3 38.2 34.7 10.4 68.1 41.6 28.8 49.1 44.4 32.5 38.6 47.4 64.1 102.4 36.4 31.6 30.1 33.1 16.2 37.5 25.5 36.5 59.1 33.3 7.9 47.1 22.8 55.6 68.3 88.7 25.1 29.1 186.8 45.4 24.1 36.9 74.7 32.2 40.9 77.8 41.3 47.4 41.8 43.1 29.8 28.1 48.0 22.2 19.9 28.7 24.7 23.4 33.0 27.4 67.1 69.0 215.3 39.5 23.0 44.0 56.7 41.3 33.5 17.2 264.4 26.3 122.5 35.4 30.8 27.9 259.5 238.3 18.0 38.2 26.5 34.8 24.4 42.8 87.7 45.3 107.7 29.0 80.7 147.5 318.0 35.3 125.8 44.4 417.0 55.3 65.2 34.0 54.6 57.0 30.8 36.9 52.9 90.5 16.9 49.7 283.0 24.5 26.7 34.8 33.6 28.4 69.2 67.5 195.3 34.0 153.6 24.6 12.6 17.8 19.2 8.4 27.6 6.3 6.1 6.3 7.0 10.2 6.4 5.0 4.9 35.7 6.9 33.7 9.0 4.4 15.9 42.4 42.7 31.6 63.8 44.4 32.5 36.4 31.6 36.5 29.1 36.9 41.8 33.4 3.2 17.9 0.0 16.7 0.0 0.0 0.0 0.0 0.0 24.5 19.7 0.0 0.0 4.3 5.5 0.0 8.9 80.2 0.0 1.9 10.3 0.0 16.6 14.7 9.0 0.0 0.0 0.0 12.6 5.9 6.1 0.0 18.9 21.5 22.3 0.0 0.0 35.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 37.6 0.0 0.0 8.8 0.0 0.0 0.0 0.0 32.4 0.0 0.0 17.7 0.0 0.0 5.6 0.7 0.0 0.0 0.0 10.0 0.0 0.0 0.0 0.0 9.6 31.0 36.3 0.0 0.0 GRK3 "ADRBK2, BARK2" ENSG00000100077 "G protein-coupled receptor kinase 3" P35626 22 25564675-25729294 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 30.2" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 32.2;Club cells: 16.7;Extravillous trophoblasts: 29.2;granulocytes: 18.9;Hofbauer cells: 29.3;Macrophages: 26.4;monocytes: 27.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 9 "classical monocyte: 4.1;eosinophil: 5.2;intermediate monocyte: 7.2;memory B-cell: 4.1;myeloid DC: 3.2;naive B-cell: 5.0;non-classical monocyte: 6.8;plasmacytoid DC: 2.7" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HDLM-2: 43.6;JURKAT: 69.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000804 Uncertain Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 2: Immune cells - Immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 41: Macrophages - Immune response" Nucleoplasm "Plasma membrane" "HPA000804: AB_1078281" "unprognostic (1.02e-1)" "unprognostic (4.38e-2)" "unprognostic (5.68e-3)" "unprognostic (4.33e-2)" "unprognostic (2.09e-1)" "unprognostic (3.67e-2)" "unprognostic (3.29e-1)" "unprognostic (1.78e-2)" "unprognostic (1.97e-1)" "unprognostic (3.54e-1)" "unprognostic (1.95e-3)" "unprognostic (5.79e-2)" "unprognostic (1.01e-3)" "unprognostic (1.74e-1)" "unprognostic (2.87e-3)" "unprognostic (1.89e-2)" "prognostic favorable (1.29e-4)" 30.2 5.4 6.5 12.9 8.9 7.8 9.4 2.3 14.7 4.0 0.0 3.1 2.8 5.3 1.3 2.4 8.7 4.7 4.3 18.9 2.6 2.4 3.2 9.4 15.1 5.4 6.2 2.9 7.1 4.2 3.2 4.4 2.5 7.5 3.9 4.8 3.2 1.6 0.9 3.3 4.7 5.9 2.9 18.8 3.8 15.7 7.6 10.2 4.1 1.2 15.6 6.2 1.5 6.0 0.1 3.9 11.9 3.9 8.1 1.0 17.3 1.3 3.8 3.8 6.5 6.4 6.8 22.5 0.3 0.3 10.5 0.2 11.9 9.1 11.1 43.6 7.6 10.3 1.3 14.3 0.3 33.8 16.8 2.0 6.2 2.6 4.6 0.6 0.7 69.4 1.1 0.1 4.4 5.6 24.4 2.4 8.5 12.1 0.0 10.8 18.9 3.8 0.0 6.6 27.6 37.5 2.2 0.1 9.0 10.9 3.3 13.4 0.3 0.1 23.6 0.2 4.9 2.6 9.1 17.4 15.8 11.8 3.7 0.5 4.1 5.2 0.0 7.2 0.2 4.1 0.0 0.2 3.2 5.0 0.1 0.1 0.2 0.0 6.8 2.7 0.3 1.5 6.5 8.9 2.3 14.7 18.9 2.6 5.4 6.2 2.5 2.9 7.6 6.0 3.9 16.0 32.2 0.0 10.2 0.0 0.0 0.0 0.0 0.0 11.7 9.5 0.0 0.0 16.7 0.0 0.0 2.0 1.1 0.0 1.9 9.4 0.0 12.7 5.8 2.4 0.0 0.0 0.0 1.8 29.2 4.1 0.0 2.2 18.9 3.7 0.0 0.0 29.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 26.4 0.0 0.0 27.4 0.0 0.0 0.0 0.0 3.4 0.0 0.0 2.1 0.0 0.0 1.8 6.6 0.0 0.0 0.0 5.1 0.0 0.0 0.0 0.0 3.3 1.1 5.0 0.0 0.0 GRK7 GPRK7 ENSG00000114124 "G protein-coupled receptor kinase 7" Q8WTQ7 3 141778148-141818490 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Sensory transduction, Vision" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 19 "retina: 11.3" "Cell type enriched" "Detected in some" 73 "Cone photoreceptor cells: 329.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA075093, HPA078232" Enhanced Approved Mitochondria NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 79: Retina - Phototransduction" "Cluster 9: Photoreceptor cells - Phototransduction" Mitochondria "HPA075093: , HPA078232: " "unprognostic (1.11e-1)" "unprognostic (1.70e-2)" "unprognostic (3.35e-3)" "unprognostic (1.22e-2)" "unprognostic (1.13e-1)" "unprognostic (1.60e-1)" "unprognostic (1.39e-2)" "unprognostic (5.08e-2)" "unprognostic (1.21e-1)" "unprognostic (1.31e-2)" "unprognostic (3.46e-2)" "unprognostic (1.20e-1)" "unprognostic (2.53e-8)" "unprognostic (3.08e-1)" "unprognostic (1.99e-1)" "unprognostic (3.11e-1)" "unprognostic (2.91e-1)" 0.0 0.0 0.1 0.0 0.1 0.2 0.0 0.5 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 11.3 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.5 0.1 0.1 0.0 0.1 0.0 0.2 0.0 0.1 0.1 0.1 0.0 0.0 3.9 0.1 0.4 0.2 0.0 0.6 1.0 0.1 0.1 0.2 0.0 0.0 0.0 329.4 0.0 0.2 0.0 0.0 0.0 1.0 0.1 0.1 0.1 0.0 0.0 2.5 0.0 0.0 0.1 0.0 0.1 0.0 0.4 0.0 0.0 0.1 0.0 2.1 0.0 0.0 0.0 0.4 2.4 0.0 0.1 0.0 1.9 0.1 1.1 0.0 4.5 3.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 0.0 0.5 0.1 0.1 0.0 0.2 0.3 0.0 0.1 0.3 0.1 0.0 GTF2F1 "BTF4, RAP74, TF2F1, TFIIF" ENSG00000125651 "General transcription factor IIF subunit 1" P35269 19 6379572-6393981 "Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" DNA-binding "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 228.3;Late spermatids: 391.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022793, HPA028707, HPA070752" Supported Enhanced "Nucleoplasm,Vesicles,Cell Junctions" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 16: U-266 - Nucleosome" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "Vesicles, Cell Junctions" "HPA022793: AB_1857946, HPA028707: AB_2672745, HPA070752: AB_2732163" "unprognostic (1.30e-2)" "unprognostic (6.05e-3)" "unprognostic (2.00e-1)" "prognostic favorable (8.39e-4)" "unprognostic (3.18e-1)" "unprognostic (8.46e-2)" "unprognostic (1.05e-1)" "unprognostic (1.38e-1)" "unprognostic (1.23e-1)" "unprognostic (5.99e-2)" "unprognostic (6.45e-3)" "unprognostic (6.96e-2)" "prognostic favorable (9.80e-4)" "unprognostic (1.34e-2)" "unprognostic (7.02e-2)" "unprognostic (9.92e-2)" "unprognostic (4.25e-1)" 35.0 38.1 36.7 34.0 38.4 71.0 34.2 43.6 43.0 48.8 30.2 41.2 40.5 48.5 25.9 46.0 44.8 36.1 32.8 39.1 35.8 37.6 30.0 31.5 43.5 34.4 34.3 73.6 57.5 42.6 49.8 26.8 34.6 39.5 23.3 24.9 43.8 31.7 36.8 36.8 39.2 25.1 30.1 36.4 43.9 68.3 36.1 37.1 49.6 22.6 29.8 37.3 41.0 36.1 115.6 97.1 62.0 100.9 46.5 73.1 47.3 81.7 84.7 112.0 106.0 104.4 48.5 76.3 111.9 67.2 73.5 109.9 69.3 65.6 57.1 106.6 90.1 97.2 60.7 86.9 78.6 107.1 79.5 82.8 78.2 85.5 64.1 86.4 69.0 72.9 115.9 91.7 63.9 96.2 115.4 79.7 108.2 59.7 124.3 101.5 68.0 94.6 67.5 74.2 76.1 99.8 83.0 64.5 95.6 36.4 84.0 94.0 79.8 78.5 62.6 134.0 110.1 153.9 197.2 79.7 98.1 124.9 91.0 10.2 29.7 20.8 26.1 28.4 29.7 32.9 23.5 24.9 23.3 31.6 27.0 24.6 40.1 27.6 30.2 30.3 25.4 19.8 36.7 38.4 43.6 43.0 39.1 35.8 34.4 34.3 34.6 30.1 36.1 36.1 29.2 48.1 56.6 5.2 51.9 24.3 50.2 40.5 53.5 27.6 43.1 34.7 28.9 32.9 58.4 25.8 8.4 46.1 51.6 88.2 21.5 48.5 228.3 70.5 70.7 41.0 30.5 51.7 6.9 50.8 43.0 43.3 51.0 57.4 63.8 32.7 58.9 26.0 60.2 25.2 7.0 53.4 24.4 54.8 25.9 391.6 44.4 42.1 33.8 5.6 66.0 35.6 49.4 3.5 4.9 47.4 66.0 49.7 55.4 29.9 65.3 48.8 83.6 33.5 32.9 44.8 52.9 71.8 38.3 44.9 21.0 54.0 48.3 41.8 54.4 40.6 GTF3C4 "KAT12, TFIIIC90" ENSG00000125484 "General transcription factor IIIC subunit 4" Q9UKN8 9 132670035-132694953 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transcription "Acyltransferase, DNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA069369 Supported Nucleoplasm,Mitochondria No No "Cluster 40: NK-cells - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm Mitochondria "HPA069369: AB_2686130" "unprognostic (7.02e-2)" "unprognostic (9.01e-2)" "unprognostic (1.31e-1)" "unprognostic (4.10e-2)" "unprognostic (8.20e-2)" "unprognostic (2.78e-1)" "unprognostic (3.71e-3)" "unprognostic (1.69e-2)" "unprognostic (1.58e-1)" "unprognostic (1.76e-1)" "unprognostic (4.77e-1)" "unprognostic (1.92e-2)" "prognostic favorable (2.99e-4)" "unprognostic (1.65e-1)" "unprognostic (1.23e-1)" "unprognostic (2.35e-1)" "unprognostic (1.54e-2)" 4.9 4.4 4.3 4.6 5.0 6.9 8.4 9.2 4.3 7.3 3.6 5.3 3.9 6.6 5.5 6.7 6.6 5.2 5.8 4.5 5.2 6.0 5.3 5.7 5.0 3.4 4.8 10.3 6.1 9.4 3.2 6.4 3.7 6.2 5.4 5.5 7.3 5.7 5.8 9.8 3.6 6.2 3.6 4.5 5.8 8.3 5.6 8.1 9.5 8.0 6.6 5.0 3.8 3.8 15.2 21.7 25.8 22.5 12.3 14.4 20.0 15.1 18.4 19.6 14.4 25.4 10.9 22.7 9.8 18.6 18.1 33.8 39.8 23.6 21.1 15.4 19.1 19.0 28.9 10.8 12.8 28.6 12.4 11.4 17.6 20.4 26.1 11.6 16.8 15.1 32.7 11.4 14.0 24.6 17.8 13.3 33.1 22.2 21.4 17.6 31.1 20.6 14.3 12.5 36.3 24.6 25.9 25.8 15.9 15.8 35.4 12.1 17.8 32.9 18.7 15.1 21.6 4.9 12.3 25.1 13.5 17.8 20.7 0.0 0.3 0.2 0.5 0.3 0.4 0.5 0.4 0.6 0.2 0.4 0.5 0.5 0.3 0.5 0.2 0.5 0.4 0.2 4.3 5.0 9.2 4.3 4.5 5.2 3.4 4.8 3.7 3.6 5.6 3.8 9.9 19.2 11.5 2.3 7.8 30.7 6.9 6.9 21.6 15.5 19.1 14.7 14.6 1.5 6.7 3.7 14.6 7.5 9.0 6.6 7.9 8.3 6.5 21.5 26.2 11.6 13.1 8.2 3.2 6.3 7.5 13.0 8.6 17.7 1.3 17.1 10.0 8.6 6.3 20.2 3.1 8.1 10.2 7.6 9.3 3.7 19.0 6.3 3.6 1.9 7.1 11.9 7.2 1.0 2.1 5.8 7.0 19.2 10.7 11.6 3.8 6.6 16.2 16.9 0.0 18.8 10.9 16.7 13.8 22.1 40.1 6.4 8.8 18.2 9.0 6.4 HACE1 KIAA1320 ENSG00000085382 "HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1" Q8IYU2 6 104728094-104859919 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Transcription, Transcription regulation, Ubl conjugation pathway" Transferase "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 30.6" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 45.9;Excitatory neurons: 118.8;Inhibitory neurons: 84.2;Microglial cells: 45.9;Oligodendrocyte precursor cells: 64.3;Oligodendrocytes: 74.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046071 Supported "Nuclear bodies,Endoplasmic reticulum" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 28: Placenta - Pregnancy" "Cluster 28: BEWO - Transcription regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Endoplasmic reticulum" "Nuclear bodies" "HPA046071: AB_2679524" "unprognostic (6.32e-2)" "unprognostic (3.77e-2)" "unprognostic (2.93e-2)" "unprognostic (1.12e-2)" "unprognostic (3.75e-2)" "unprognostic (3.75e-3)" "unprognostic (1.22e-3)" "unprognostic (4.63e-2)" "unprognostic (7.41e-2)" "unprognostic (1.24e-1)" "unprognostic (1.56e-2)" "unprognostic (2.25e-1)" "prognostic unfavorable (1.17e-5)" "unprognostic (1.12e-2)" "unprognostic (2.06e-1)" "prognostic unfavorable (7.50e-4)" "unprognostic (1.75e-1)" 3.7 3.2 2.7 2.2 4.4 2.9 3.1 5.0 4.8 3.9 0.4 2.6 2.1 3.9 1.1 5.3 3.3 3.1 3.3 3.1 2.5 6.2 1.6 3.6 2.2 1.9 2.6 3.8 1.9 7.2 1.5 30.6 2.3 3.7 1.8 11.5 2.9 4.1 2.2 2.5 2.1 4.0 1.4 2.5 2.4 10.4 3.1 3.9 4.5 4.1 2.4 3.3 2.9 5.8 3.9 2.7 11.3 14.3 6.6 8.8 13.3 7.7 11.9 4.8 7.2 2.5 2.3 2.2 3.4 5.9 8.1 2.6 2.8 5.3 10.0 9.1 7.2 7.7 2.5 3.4 6.6 6.8 2.5 5.9 4.7 6.2 5.2 6.3 8.0 9.2 7.6 2.4 9.6 2.8 5.1 4.1 5.0 2.9 2.6 8.0 12.8 0.9 3.8 6.6 6.1 9.1 4.2 4.3 2.3 7.3 2.7 9.2 8.5 3.9 3.2 10.5 7.4 3.5 4.1 7.6 4.0 6.4 7.1 0.0 0.6 0.7 1.2 1.0 1.3 0.9 1.1 1.1 0.6 0.8 1.2 0.9 0.1 0.8 0.5 0.8 0.4 0.5 2.7 4.4 5.0 4.8 3.1 2.5 1.9 2.6 2.3 1.4 3.1 5.8 11.6 3.2 1.1 42.4 5.1 4.7 2.3 2.3 5.2 11.6 5.3 3.7 6.7 1.5 3.9 5.5 45.9 10.6 4.1 1.5 1.9 1.6 6.2 2.7 6.2 12.9 1.8 3.0 118.8 1.5 5.4 7.1 5.6 3.4 1.3 7.1 4.2 2.6 5.7 16.8 84.2 2.0 0.0 4.1 2.4 4.6 6.2 3.5 1.8 45.9 4.3 6.1 8.2 64.3 74.6 1.4 2.9 3.8 3.7 1.6 3.8 5.7 2.6 31.7 6.6 6.4 6.6 13.2 3.5 5.3 4.7 6.3 6.2 2.9 1.9 1.9 HAT1 KAT1 ENSG00000128708 "Histone acetyltransferase 1" O14929 2 171922448-171983686 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036788, CAB037191" Supported Supported Nucleoplasm NA NA 27000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Nucleoplasm "CAB037191: AB_477070, HPA036788: AB_10672267" "unprognostic (1.76e-1)" "unprognostic (1.01e-2)" "unprognostic (7.39e-3)" "unprognostic (8.24e-3)" "unprognostic (2.76e-1)" "unprognostic (1.54e-1)" "prognostic unfavorable (5.72e-5)" "unprognostic (2.71e-2)" "unprognostic (9.08e-3)" "unprognostic (3.69e-2)" "unprognostic (1.56e-2)" "unprognostic (1.24e-1)" "unprognostic (3.23e-2)" "unprognostic (6.89e-2)" "unprognostic (1.80e-1)" "unprognostic (3.97e-2)" "unprognostic (6.69e-2)" 27.7 27.0 14.3 33.5 15.5 59.8 41.4 15.9 19.2 26.8 15.3 27.7 19.9 24.6 16.7 26.6 24.4 24.6 31.4 13.1 16.2 32.2 30.2 25.7 48.7 15.0 14.6 23.2 30.0 37.9 16.9 30.6 15.5 29.0 30.7 28.8 32.8 24.0 67.7 23.8 21.7 29.3 16.1 27.7 23.6 20.1 15.5 50.7 32.8 50.8 47.5 39.0 19.6 17.3 132.4 61.5 106.6 98.8 55.2 56.8 75.2 133.9 88.9 144.4 149.9 144.3 88.2 147.0 85.0 81.5 122.7 101.3 116.7 109.5 220.5 83.5 115.8 131.1 91.5 131.0 26.7 165.5 77.9 34.2 62.2 191.0 63.6 45.5 92.6 100.4 136.5 93.1 166.5 91.8 131.1 148.3 89.0 158.9 63.9 102.8 134.4 99.4 85.3 130.2 67.8 55.4 112.4 62.4 118.1 81.5 86.4 164.5 47.5 129.8 99.2 109.5 137.1 40.9 100.5 173.8 87.6 117.8 113.8 47.6 35.3 53.7 32.8 42.0 40.6 35.5 34.9 34.0 27.4 30.7 33.9 37.6 40.3 44.6 59.2 14.3 49.2 34.0 14.3 15.5 15.9 19.2 13.1 16.2 15.0 14.6 15.5 16.1 15.5 17.3 55.6 35.3 28.9 13.7 49.7 74.2 117.7 129.7 46.1 24.2 36.4 42.3 49.5 25.8 66.2 27.6 33.3 77.5 43.5 19.0 82.2 45.2 70.3 33.1 32.3 43.2 14.3 103.1 28.6 46.5 83.1 43.7 15.8 28.9 40.6 30.7 28.9 20.1 51.8 28.6 45.3 20.9 111.9 29.5 36.3 14.7 30.7 34.5 32.0 16.9 28.8 53.4 43.3 21.6 28.0 27.8 21.0 36.9 50.8 52.0 18.2 46.0 65.4 42.0 39.5 43.8 51.3 65.7 67.5 28.8 52.7 58.3 49.0 43.9 29.4 64.1 HDAC3 "HD3, KDAC3, RPD3, RPD3-2" ENSG00000171720 "Histone deacetylase 3" O15379 5 141620876-141636849 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Biological rhythms, Host-virus interaction, Transcription, Transcription regulation" "Chromatin regulator, Hydrolase, Repressor" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005583, HPA052052, CAB072336" Supported Supported "Nucleoplasm,Golgi apparatus" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 3: Monocytes - Immune response regulation" Nucleoplasm "Golgi apparatus" "CAB005583: AB_562296, CAB072336: , HPA052052: AB_2681708" "unprognostic (6.65e-2)" "unprognostic (1.96e-1)" "prognostic favorable (3.39e-4)" "unprognostic (1.17e-1)" "unprognostic (1.24e-1)" "unprognostic (1.07e-1)" "unprognostic (1.19e-2)" "unprognostic (3.16e-1)" "unprognostic (5.56e-2)" "unprognostic (2.45e-2)" "prognostic favorable (3.95e-4)" "unprognostic (1.12e-1)" "prognostic unfavorable (2.65e-6)" "unprognostic (1.85e-1)" "unprognostic (1.63e-2)" "unprognostic (2.28e-3)" "unprognostic (2.17e-1)" 24.3 39.8 7.8 22.7 8.4 37.3 25.3 7.8 9.5 25.7 9.9 23.3 18.7 23.5 26.4 34.1 26.5 20.3 24.4 8.7 8.4 24.2 39.6 21.4 32.7 8.2 8.0 26.0 28.4 44.9 18.4 22.4 7.9 20.6 24.5 16.4 25.5 21.9 40.2 40.8 23.5 26.1 8.5 27.8 23.3 15.8 8.5 38.3 24.1 34.1 42.7 26.2 25.8 8.2 59.8 40.2 74.0 109.5 68.5 54.3 47.0 42.6 93.5 94.8 134.8 86.5 49.7 86.4 54.0 56.2 67.3 51.2 72.9 98.8 117.0 74.6 79.0 68.8 33.3 50.4 48.1 83.5 60.1 47.0 63.2 55.3 71.3 49.6 61.9 76.8 67.6 44.7 61.5 55.8 92.1 72.9 63.9 36.8 31.0 65.8 76.2 62.3 49.9 59.7 60.2 49.4 57.0 57.1 71.7 46.2 61.8 52.3 32.1 58.3 36.1 45.8 71.8 36.6 47.8 82.1 48.8 78.6 50.8 41.3 51.7 39.6 34.1 53.8 45.5 47.8 42.5 41.9 107.5 47.5 45.9 38.5 21.5 35.1 46.8 55.1 55.6 43.8 7.8 8.4 7.8 9.5 8.7 8.4 8.2 8.0 7.9 8.5 8.5 8.2 19.1 9.6 13.2 16.6 36.0 44.2 26.8 38.1 37.0 33.2 29.0 25.5 15.9 18.6 19.6 12.9 60.5 55.3 43.8 18.5 21.5 33.4 10.4 10.0 21.0 21.3 18.0 50.7 40.6 35.4 51.6 28.8 19.9 10.2 18.4 33.9 21.4 18.7 38.8 50.5 38.2 19.7 28.5 19.5 44.9 4.2 22.4 31.7 32.0 10.3 51.1 33.3 38.1 22.1 21.9 33.4 16.3 22.2 36.3 28.7 19.5 20.5 10.8 36.5 26.3 18.1 24.7 25.4 27.5 38.1 51.4 61.2 30.3 42.6 25.9 30.3 HECTD1 KIAA1131 ENSG00000092148 "HECT domain E3 ubiquitin protein ligase 1" Q9ULT8 14 31100112-31207804 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 218.4" "Cell type enhanced" "Detected in all" "Urothelial cells: 302.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002929, HPA054461" Approved Enhanced Nucleoplasm,Nucleoli NA NA "Cluster 46: Basophils - DNA binding" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Nucleoli" "HPA002929: AB_1850574, HPA054461: AB_2682496" "unprognostic (6.71e-2)" "unprognostic (4.86e-2)" "unprognostic (5.31e-2)" "unprognostic (1.25e-1)" "unprognostic (1.64e-1)" "unprognostic (6.99e-2)" "unprognostic (1.32e-1)" "unprognostic (7.03e-2)" "unprognostic (2.29e-2)" "unprognostic (3.13e-2)" "unprognostic (3.60e-3)" "unprognostic (1.51e-1)" "prognostic favorable (1.20e-6)" "unprognostic (6.53e-2)" "unprognostic (1.22e-1)" "unprognostic (1.07e-1)" "unprognostic (9.91e-3)" 43.0 48.6 27.8 23.1 33.6 54.0 37.6 58.6 33.7 43.5 34.0 38.3 25.1 37.0 30.7 74.6 33.8 26.7 47.2 27.2 30.9 37.0 74.3 32.9 28.7 30.2 30.1 38.5 34.7 56.5 34.4 35.5 32.5 30.7 31.2 66.9 42.6 31.0 218.4 50.8 33.6 30.8 28.0 30.4 43.7 42.7 31.3 26.3 51.3 133.6 37.3 39.8 51.5 36.6 95.1 54.6 49.2 30.4 144.0 77.2 44.7 54.8 54.1 47.4 39.7 41.0 47.8 72.1 57.8 97.3 34.0 62.6 63.2 47.7 69.6 44.5 24.9 75.6 44.3 163.9 66.9 81.8 52.7 66.3 64.4 52.2 80.9 63.6 87.5 42.2 54.4 32.1 72.8 72.4 31.8 31.7 36.0 76.6 47.5 53.6 58.0 30.4 71.3 93.2 36.2 40.8 79.8 54.5 49.0 56.3 58.7 49.5 93.4 56.6 42.9 41.9 49.0 34.3 52.9 79.0 28.0 37.3 49.7 9.1 5.7 8.3 4.5 4.8 5.2 4.8 5.2 4.1 6.4 6.3 4.2 4.3 3.0 6.3 3.8 5.3 5.6 2.4 27.8 33.6 58.6 33.7 27.2 30.9 30.2 30.1 32.5 28.0 31.3 36.6 63.4 48.1 80.8 84.5 60.7 86.7 93.5 61.2 48.3 98.9 40.8 28.6 108.1 25.8 94.8 71.7 98.0 70.2 72.1 40.9 11.7 44.2 3.6 101.6 83.0 60.0 48.7 41.2 89.9 36.1 42.9 59.9 96.8 118.1 32.9 81.6 46.4 84.7 29.0 65.6 101.1 33.0 63.1 43.9 34.5 8.7 69.0 54.0 33.8 90.9 65.1 40.9 78.2 100.0 127.9 52.6 33.9 74.4 71.1 106.3 37.1 22.4 148.4 194.5 46.0 77.4 78.9 50.6 100.0 83.7 114.9 140.0 61.4 97.0 44.5 302.9 HECTD2 FLJ37306 ENSG00000165338 "HECT domain E3 ubiquitin protein ligase 2" Q5U5R9 10 91409280-91514829 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 127.5;Inhibitory neurons: 99.4;Microglial cells: 60.0;Oligodendrocyte precursor cells: 87.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 6 "NK-cell: 2.8" "Lineage enriched" "Detected in single" 6 "NK-cells: 2.8" "Cell line enhanced" "Detected in many" "AF22: 29.0" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebellum: 56.1" HPA037767 Approved Approved Nucleoplasm NA NA "Cluster 15: NK-cells - Transcription" "Cluster 89: Fibroblasts - ECM organization" "Cluster 12: NES - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "HPA037767: AB_10671378" "unprognostic (6.35e-2)" "unprognostic (1.33e-1)" "unprognostic (3.26e-2)" "unprognostic (3.34e-1)" "unprognostic (6.65e-3)" "unprognostic (1.10e-2)" "unprognostic (9.37e-4)" "unprognostic (1.42e-1)" "unprognostic (1.59e-1)" "unprognostic (2.31e-1)" "unprognostic (2.54e-3)" "unprognostic (4.44e-2)" "prognostic unfavorable (1.67e-5)" "unprognostic (6.98e-3)" "unprognostic (1.39e-1)" "unprognostic (1.93e-1)" "unprognostic (5.84e-2)" 6.6 5.8 6.9 3.7 7.7 1.6 7.3 8.1 8.7 9.0 2.2 8.3 3.0 12.0 11.3 5.3 9.4 7.9 6.0 7.2 5.2 7.1 3.2 6.9 3.4 3.5 3.6 11.8 5.3 7.5 6.9 7.3 1.9 16.8 5.0 11.7 5.7 16.4 5.8 4.6 4.6 12.6 3.3 3.8 5.5 7.0 5.3 3.8 6.7 7.2 2.3 8.2 7.4 6.8 5.8 2.9 29.0 12.0 6.2 6.8 5.2 4.7 6.2 9.2 8.5 0.3 5.4 0.0 3.9 4.8 5.4 0.4 7.9 3.3 11.3 6.3 9.8 3.4 23.1 1.8 3.1 0.7 2.1 7.0 2.9 6.7 5.7 13.0 7.0 7.1 4.5 14.6 14.5 2.7 3.6 1.8 12.1 0.5 2.9 9.0 19.1 3.5 6.5 1.6 6.8 7.2 9.1 2.0 9.4 8.8 13.2 2.0 7.3 9.2 6.3 0.6 8.9 1.0 2.0 8.2 8.1 0.1 5.4 0.0 0.0 0.0 0.4 0.4 0.3 0.1 0.2 0.3 0.2 0.2 0.2 0.2 0.0 2.8 0.1 0.0 0.0 0.2 6.9 7.7 8.1 8.7 7.2 5.2 3.5 3.6 1.9 3.3 5.3 6.8 9.4 0.0 5.1 45.4 3.5 6.1 8.8 3.6 8.6 20.6 6.3 8.4 7.9 4.3 6.0 5.5 27.1 0.4 1.2 1.1 21.5 2.7 2.8 6.8 14.2 8.9 9.0 1.3 127.5 3.7 0.4 12.8 7.1 7.3 3.8 7.8 8.2 1.2 6.5 28.6 99.4 2.7 4.1 7.0 6.5 2.0 12.2 7.0 7.2 60.0 2.3 13.1 0.0 87.0 21.2 2.5 1.4 14.3 4.5 4.9 0.5 1.4 7.2 9.1 13.1 15.8 10.5 9.5 9.5 8.4 4.4 0.4 3.0 4.5 1.2 4.3 HECTD3 FLJ21156 ENSG00000126107 "HECT domain E3 ubiquitin protein ligase 3" Q5T447 1 45002540-45011324 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 33.7;Proximal enterocytes: 44.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027467 Approved NA NA "Cluster 34: Basophils - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 45: Enterocytes - Digestion" "HPA027467: AB_10600710" "unprognostic (1.86e-1)" "unprognostic (1.19e-2)" "unprognostic (2.39e-1)" "unprognostic (1.58e-1)" "unprognostic (1.18e-1)" "unprognostic (2.05e-1)" "prognostic unfavorable (2.14e-5)" "unprognostic (1.74e-2)" "unprognostic (2.92e-2)" "unprognostic (7.42e-2)" "unprognostic (2.47e-1)" "unprognostic (8.39e-2)" "unprognostic (2.65e-1)" "unprognostic (7.52e-2)" "unprognostic (3.35e-1)" "prognostic favorable (1.85e-6)" "unprognostic (3.19e-1)" 22.8 24.5 19.7 12.3 21.2 15.0 20.0 20.9 20.6 17.1 18.7 33.2 47.2 18.1 16.0 26.4 13.8 12.3 17.0 20.4 20.7 19.6 30.5 14.0 16.5 22.2 20.5 19.5 37.0 26.7 11.9 14.2 22.3 14.8 26.2 7.4 34.1 15.6 39.9 27.9 40.4 14.8 19.8 20.1 22.6 13.6 20.9 12.7 17.0 24.0 14.4 20.4 18.9 22.6 22.1 19.8 12.4 20.1 42.5 26.5 24.3 20.6 31.2 22.3 25.2 28.7 6.8 10.3 17.1 34.1 50.0 20.2 29.7 21.5 20.0 19.3 22.8 16.6 28.4 24.9 37.2 13.0 26.8 28.6 36.5 38.4 14.8 23.2 50.4 17.8 38.0 11.3 28.9 18.8 16.6 10.6 17.1 24.9 29.6 19.5 22.7 15.0 33.2 25.7 29.7 12.4 27.9 47.8 25.5 31.1 15.5 12.0 38.0 25.7 20.4 32.2 23.9 14.4 18.3 5.8 41.3 14.0 12.9 10.7 8.0 8.0 7.3 10.9 6.3 6.0 6.1 6.5 7.3 3.3 5.0 6.1 2.8 4.0 6.3 5.5 6.7 6.5 19.7 21.2 20.9 20.6 20.4 20.7 22.2 20.5 22.3 19.8 20.9 22.6 6.9 3.2 8.2 7.2 5.6 3.8 2.2 3.1 8.6 5.2 8.5 6.2 6.0 8.6 5.8 5.5 6.2 7.1 9.2 33.7 1.9 10.3 1.2 4.0 7.5 7.0 2.4 20.6 5.4 15.5 14.2 7.0 21.4 8.1 6.3 6.4 6.4 14.1 13.6 6.7 5.0 15.1 0.0 15.3 2.9 2.3 14.6 7.8 3.6 4.7 10.2 3.1 5.2 2.0 4.7 13.2 28.1 9.8 9.1 2.8 44.8 6.9 1.4 6.2 6.6 4.5 6.7 4.5 7.4 9.7 6.1 6.0 7.1 13.5 14.9 2.3 HECW1 "KIAA0322, NEDL1" ENSG00000002746 "HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1" Q76N89 7 43112629-43566001 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 16.4;kidney: 7.8" "Cell type enhanced" "Detected in some" "Early spermatids: 135.6;Excitatory neurons: 533.3;Inhibitory neurons: 157.3;Late spermatids: 72.0;Oligodendrocyte precursor cells: 277.9" "Not detected" "Not detected" "Region enriched" "Detected in many" 4 "cerebral cortex: 16.4" "Group enriched" "Detected in some" 4 "basophil: 4.9;neutrophil: 3.3" "Lineage enriched" "Detected in many" 5 "granulocytes: 4.9" "Cell line enhanced" "Detected in some" "A549: 3.8;GAMG: 3.7;U-266/70: 12.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007203, HPA007593, HPA007609" Uncertain Supported Cytosol NA NA "Cluster 17: Basophils - Unknown function" "Cluster 58: Brain - Synaptic function" "Cluster 29: U-266 - Adaptive immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "HPA007203: AB_2667776, HPA007593: AB_1852305, HPA007609: AB_2117518" "unprognostic (1.40e-1)" "unprognostic (2.85e-3)" "unprognostic (2.57e-1)" "unprognostic (4.39e-1)" "unprognostic (2.43e-2)" "unprognostic (2.80e-2)" "unprognostic (8.65e-4)" "unprognostic (6.93e-2)" "unprognostic (7.30e-2)" "unprognostic (7.31e-2)" "unprognostic (3.43e-2)" "unprognostic (2.67e-2)" "unprognostic (1.43e-3)" "unprognostic (1.64e-2)" "unprognostic (5.23e-3)" "unprognostic (1.89e-2)" "unprognostic (2.42e-2)" 0.1 0.0 1.5 0.2 1.7 0.5 0.2 0.0 16.4 0.1 0.0 0.2 0.0 0.2 0.6 1.0 0.1 1.9 0.0 0.7 0.0 7.8 0.1 0.1 0.4 0.2 0.0 0.3 0.0 0.2 0.0 0.1 0.1 1.3 0.1 2.2 0.4 0.2 0.9 0.6 0.1 0.1 0.0 0.1 0.3 1.8 0.2 0.0 0.5 2.6 0.2 0.3 0.1 3.8 0.0 3.8 0.3 0.5 0.0 0.0 0.0 1.2 2.2 0.1 0.5 0.0 0.0 0.2 2.3 2.2 3.7 0.2 0.0 0.0 0.2 0.1 0.7 0.0 0.3 0.2 0.2 1.1 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.2 0.0 2.3 0.0 0.0 0.0 0.0 1.8 0.1 0.7 0.4 0.0 0.0 0.0 0.0 0.1 0.4 0.4 0.0 0.0 0.2 0.2 0.0 0.0 0.6 0.8 0.9 0.3 12.0 0.4 0.0 2.7 0.3 0.0 4.9 0.8 0.7 0.3 0.5 0.2 0.6 0.3 0.1 0.1 1.0 0.3 0.3 3.3 0.6 0.6 0.9 0.1 0.0 1.5 1.7 0.0 16.4 0.7 0.0 0.2 0.0 0.1 0.0 0.2 3.8 0.0 0.0 0.0 7.8 0.1 0.4 0.3 0.0 0.0 15.4 0.1 0.3 1.4 0.0 0.0 0.0 4.2 0.0 0.0 0.5 0.0 0.0 135.6 1.1 3.6 0.2 0.0 0.0 533.3 0.0 0.1 0.7 0.0 0.7 0.0 0.0 0.4 0.1 0.0 45.4 157.3 0.1 0.0 0.0 1.4 72.0 0.3 0.2 0.0 24.4 0.1 0.6 0.0 277.9 4.8 0.0 1.4 0.4 0.0 0.4 4.3 15.8 0.0 1.9 0.0 0.6 0.4 3.2 3.3 0.3 0.3 0.0 0.6 0.2 0.5 0.3 HECW2 "KIAA1301, NEDL2" ENSG00000138411 "HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2" Q9P2P5 2 196189099-196593684 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 331.5;Hepatic stellate cells: 99.2;Inhibitory neurons: 375.4;Oligodendrocyte precursor cells: 143.2;Oligodendrocytes: 460.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "neutrophil: 4.7;non-classical monocyte: 3.7" "Group enriched" "Detected in many" 8 "granulocytes: 4.7;monocytes: 3.7" "Cell line enhanced" "Detected in many" "HDLM-2: 30.1;hTEC/SVTERT24-B: 16.3;HUVEC TERT2: 20.9;SCLC-21H: 31.6;TIME: 26.3;U-138 MG: 21.7" "Low region specificity" "Detected in all" HPA034609 Enhanced NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA034609: AB_10669993" "unprognostic (2.65e-2)" "unprognostic (3.89e-1)" "unprognostic (1.42e-1)" "unprognostic (9.00e-3)" "unprognostic (2.55e-1)" "unprognostic (4.28e-2)" "unprognostic (7.63e-3)" "unprognostic (1.23e-1)" "unprognostic (2.61e-2)" "unprognostic (7.05e-2)" "unprognostic (4.16e-2)" "unprognostic (2.27e-1)" "prognostic unfavorable (5.18e-5)" "unprognostic (8.05e-3)" "unprognostic (5.20e-2)" "unprognostic (1.49e-1)" "unprognostic (4.48e-2)" 4.1 1.5 2.4 1.2 3.5 0.1 1.7 4.4 6.1 2.2 0.0 0.4 0.4 0.8 0.3 3.1 3.5 2.1 8.1 3.3 0.0 1.6 2.7 5.3 2.0 1.1 0.8 0.2 0.6 4.3 1.2 7.4 2.1 0.4 0.4 2.7 0.9 0.5 1.4 0.8 0.5 1.3 0.0 6.0 0.9 3.5 1.7 0.8 3.8 3.5 2.4 1.0 0.6 8.2 0.1 1.4 2.3 0.0 1.4 4.2 1.6 2.7 7.3 2.1 2.6 0.3 0.1 1.4 0.5 13.4 3.3 3.2 0.9 0.1 4.5 30.1 1.6 0.0 2.3 0.2 0.2 0.5 0.3 1.0 1.3 16.3 5.7 4.1 20.9 0.0 0.2 0.1 6.7 1.8 0.0 0.7 2.5 0.2 1.0 0.0 0.5 0.0 0.1 0.0 31.6 2.5 2.0 0.5 0.0 0.4 0.1 0.2 26.3 21.7 1.4 4.6 0.7 0.2 0.0 1.3 5.4 0.1 0.2 0.1 0.3 0.8 0.0 1.1 0.0 0.4 0.0 0.0 0.4 0.5 0.0 0.0 4.7 0.0 3.7 0.0 0.0 0.1 2.4 3.5 4.4 6.1 3.3 0.0 1.1 0.8 2.1 0.0 1.7 8.2 61.2 0.0 12.1 12.7 3.6 2.2 0.3 0.1 3.4 9.5 1.1 0.8 18.7 0.0 0.1 0.0 0.0 0.2 0.7 0.6 0.0 0.1 11.1 0.4 1.6 34.2 2.4 0.0 331.5 0.0 0.3 4.2 0.5 0.3 1.3 4.9 99.2 1.5 0.1 0.0 375.4 0.6 0.0 7.2 3.0 5.3 0.0 1.4 3.6 14.0 1.2 12.0 0.0 143.2 460.7 0.1 0.0 2.6 3.4 0.4 0.0 0.1 1.0 1.1 0.0 1.2 2.2 0.5 6.1 9.2 1.6 0.1 1.4 0.7 0.1 0.6 HELZ2 "KIAA1769, PDIP1, PRIC285" ENSG00000130589 "Helicase with zinc finger 2" Q9BYK8 20 63558086-63574239 "Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, DNA-binding, Helicase, Hydrolase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Granulosa cells: 46.1;Urothelial cells: 47.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ hTERT+ SV40 Large T+: 59.4;GAMG: 34.5;SK-MEL-30: 25.4" "Not detected" "Not detected" "Not detected" "Not detected" HPA051267 Uncertain NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 18: Non-specific - Mitochondria" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 40: Granulosa cells - Unknown function" "HPA051267: " "unprognostic (1.86e-1)" "unprognostic (7.75e-2)" "unprognostic (2.41e-1)" "unprognostic (1.93e-3)" "unprognostic (1.35e-1)" "unprognostic (1.44e-1)" "unprognostic (2.21e-1)" "unprognostic (1.36e-2)" "unprognostic (5.06e-2)" "unprognostic (1.52e-1)" "unprognostic (1.73e-2)" "unprognostic (3.61e-2)" "unprognostic (2.19e-3)" "unprognostic (3.95e-2)" "prognostic unfavorable (4.92e-4)" "unprognostic (9.76e-2)" "unprognostic (1.16e-1)" 6.6 4.2 4.0 5.6 2.9 15.6 5.6 2.3 2.1 5.7 1.6 5.5 3.8 4.2 0.6 7.4 5.0 3.0 7.0 1.9 2.6 6.6 7.7 9.9 4.8 6.2 3.1 3.9 5.8 0.8 5.1 2.3 4.1 4.6 0.9 0.1 12.2 1.1 1.8 4.8 6.3 1.0 6.4 12.3 7.6 1.2 4.7 3.0 5.9 0.9 1.8 3.9 3.9 2.7 10.0 3.7 1.2 3.7 2.2 2.8 7.1 3.5 5.2 59.4 23.0 10.1 12.4 0.2 7.5 1.3 34.5 15.3 0.7 3.6 2.3 3.7 1.7 0.2 4.6 3.5 4.8 0.3 23.4 3.5 2.5 4.3 0.7 1.3 2.8 0.2 1.8 4.1 0.7 9.9 1.1 10.2 1.9 2.6 11.4 2.2 2.0 3.9 1.7 11.4 0.9 3.3 10.9 0.7 25.4 0.7 3.4 3.0 4.5 5.7 8.4 4.7 3.6 5.2 0.7 0.2 6.2 1.6 5.2 0.0 0.1 0.4 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.2 4.0 2.9 2.3 2.1 1.9 2.6 6.2 3.1 4.1 6.4 4.7 2.7 24.7 9.6 6.0 0.3 10.5 8.7 22.7 8.8 4.6 1.0 8.8 5.5 4.5 8.6 12.1 9.2 0.0 2.1 15.9 26.0 0.0 8.8 0.1 11.6 9.6 24.9 30.9 3.2 0.1 7.7 13.4 11.6 26.0 17.5 0.0 46.1 10.4 6.0 3.5 0.0 0.3 19.5 4.1 4.3 17.1 0.0 7.2 10.8 3.6 4.7 7.0 1.7 24.7 1.0 0.4 20.4 20.7 2.2 6.4 28.9 17.9 0.8 9.6 2.7 6.6 12.2 9.9 0.7 0.3 5.1 8.4 1.9 14.7 17.7 14.5 47.4 HERC1 "p532, p619" ENSG00000103657 "HECT and RLD domain containing E3 ubiquitin protein ligase family member 1" Q15751 15 63608618-63833948 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Transport, Ubl conjugation pathway" "Guanine-nucleotide releasing factor, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 458.8;Inhibitory neurons: 338.0;Oligodendrocytes: 201.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049749 Uncertain NA NA "Cluster 17: Basophils - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA049749: AB_2680866" "unprognostic (9.72e-2)" "unprognostic (7.51e-2)" "unprognostic (3.43e-1)" "unprognostic (3.80e-1)" "unprognostic (2.35e-1)" "prognostic favorable (4.87e-5)" "unprognostic (1.53e-1)" "unprognostic (2.15e-2)" "unprognostic (3.02e-2)" "unprognostic (2.89e-3)" "prognostic favorable (3.66e-4)" "unprognostic (1.24e-1)" "prognostic favorable (1.36e-6)" "unprognostic (2.87e-1)" "unprognostic (3.36e-2)" "unprognostic (9.04e-3)" "unprognostic (3.94e-1)" 10.5 7.4 8.6 10.3 10.1 27.4 12.7 14.1 20.3 13.0 5.2 11.8 5.3 10.8 6.5 8.1 7.6 9.6 15.2 9.3 0.0 9.1 9.1 10.6 13.7 1.7 0.3 18.5 8.4 22.7 8.8 10.3 1.8 8.6 9.2 18.3 8.8 10.3 30.4 12.1 9.9 12.4 0.0 15.2 10.2 11.5 0.0 25.6 14.0 29.3 12.8 9.2 7.9 22.7 13.5 17.1 19.1 6.6 33.3 21.1 6.4 10.3 13.4 10.7 12.3 10.9 5.3 19.8 9.3 19.8 9.7 14.5 31.2 9.0 14.6 15.4 9.6 42.5 26.4 7.8 5.3 31.6 25.1 15.3 8.5 15.1 14.5 9.3 22.7 13.3 44.0 8.6 9.4 21.7 11.3 6.5 9.3 10.4 8.7 12.2 20.6 11.6 4.4 32.9 17.0 8.4 18.2 12.5 10.5 23.0 6.1 12.7 23.6 13.6 12.6 11.9 13.6 9.4 17.4 13.3 7.8 23.3 4.9 24.4 3.8 8.7 4.9 3.4 3.7 5.9 5.5 4.6 3.4 9.5 5.5 5.4 13.5 2.9 6.7 7.5 7.8 1.8 8.6 10.1 14.1 20.3 9.3 0.0 1.7 0.3 1.8 0.0 0.0 22.7 66.0 6.4 39.5 113.0 44.2 14.9 10.6 16.1 17.1 65.3 19.7 17.1 64.8 17.2 19.9 22.0 66.7 8.8 66.1 11.4 1.9 11.0 28.7 13.5 24.0 44.5 10.2 47.5 458.8 14.1 15.1 28.5 34.7 17.8 50.6 36.5 47.2 21.0 16.2 85.8 338.0 13.1 10.2 43.2 27.4 14.3 27.7 39.2 19.6 137.7 36.0 29.9 35.0 160.4 201.5 11.7 14.7 39.9 44.9 12.7 12.5 15.7 16.6 55.0 6.6 34.4 36.0 43.5 31.3 17.1 15.3 8.9 61.1 31.9 14.4 12.1 HERC2 "D15F37S1, jdf2, p528" ENSG00000128731 "HECT and RLD domain containing E3 ubiquitin protein ligase 2" O95714 15 28111040-28322179 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HEL: 54.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017188, HPA048389, HPA074166" Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 59: Non-specific - Translation" "Cluster 36: HEL - Hemostasis" "Cluster 40: Granulosa cells - Unknown function" Cytosol "Plasma membrane" "CAB017188: , HPA048389: AB_2680382, HPA074166: " "unprognostic (1.59e-1)" "unprognostic (1.44e-1)" "unprognostic (1.92e-1)" "unprognostic (6.64e-2)" "unprognostic (6.62e-2)" "unprognostic (5.74e-2)" "unprognostic (9.17e-2)" "unprognostic (2.08e-1)" "unprognostic (1.87e-1)" "unprognostic (4.11e-2)" "unprognostic (9.40e-3)" "unprognostic (3.60e-2)" "prognostic favorable (1.41e-7)" "unprognostic (7.66e-2)" "unprognostic (2.10e-1)" "unprognostic (2.34e-2)" "unprognostic (1.71e-1)" 5.3 5.7 2.5 2.3 2.9 4.0 4.9 1.5 3.1 5.5 3.0 9.3 2.6 7.6 1.7 5.2 6.1 2.2 7.4 2.3 1.1 3.7 3.7 5.1 2.3 2.0 1.8 8.3 6.1 5.4 6.3 2.7 2.7 4.4 2.8 5.3 4.8 2.9 14.2 5.3 6.1 3.7 0.4 4.3 6.3 4.8 2.7 4.4 5.8 9.3 2.4 5.6 5.0 6.2 8.5 16.5 11.2 4.7 9.2 6.9 3.2 6.0 7.1 7.6 7.3 8.6 1.1 8.5 7.2 10.4 11.5 8.5 12.0 5.9 5.6 5.2 7.8 54.0 20.2 2.9 3.5 12.8 4.1 5.7 4.5 9.0 11.2 4.9 10.2 7.0 21.2 3.4 7.3 3.9 2.9 4.3 3.4 6.4 7.1 10.2 16.0 0.7 2.6 18.2 12.3 7.1 14.6 4.1 4.5 5.8 4.8 14.8 15.3 14.0 9.2 5.5 9.1 2.2 3.3 7.7 6.5 5.9 7.6 0.1 0.2 0.1 0.3 0.0 0.1 0.2 0.1 0.1 0.2 0.4 0.2 0.1 0.0 0.1 0.1 0.6 0.2 0.1 2.5 2.9 1.5 3.1 2.3 1.1 2.0 1.8 2.7 0.4 2.7 6.2 56.2 22.4 23.5 68.9 34.3 16.4 15.3 18.1 27.9 107.9 39.1 31.2 66.6 21.5 23.6 64.4 148.0 25.9 28.5 31.8 1.9 28.7 13.0 35.0 55.8 73.3 28.1 67.9 88.9 30.4 15.5 34.3 43.3 29.6 3.8 135.0 38.9 36.7 19.0 122.8 82.9 32.1 16.2 22.3 20.7 15.8 56.2 22.1 69.4 84.3 26.9 41.0 45.3 65.9 89.7 36.6 30.8 52.3 56.6 20.5 31.1 19.8 19.6 142.9 65.7 46.0 43.2 72.5 66.4 38.3 21.0 17.8 30.0 62.7 35.5 11.5 HERC3 KIAA0032 ENSG00000138641 "HECT and RLD domain containing E3 ubiquitin protein ligase 3" Q15034 4 88592434-88708541 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 5 "retina: 114.1" "Group enriched" "Detected in some" 9 "Cardiomyocytes: 23.8;Cytotrophoblasts: 7.0;Extravillous trophoblasts: 17.3;Hofbauer cells: 9.3;Syncytiotrophoblasts: 7.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 48.2;hTERT-HME1: 68.6" HPA039170 Approved Supported Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 77: Retina - Visual perception" "Cluster 30: Epithelial cell lines - Translation" "Cluster 38: Extravillous trophoblasts - Unknown function" Cytosol "HPA039170: AB_10673414" "unprognostic (2.21e-2)" "unprognostic (1.65e-2)" "unprognostic (9.28e-3)" "unprognostic (3.24e-1)" "unprognostic (6.26e-2)" "unprognostic (1.88e-2)" "unprognostic (1.30e-2)" "unprognostic (1.85e-2)" "unprognostic (9.77e-2)" "unprognostic (6.51e-3)" "unprognostic (3.48e-3)" "unprognostic (2.58e-2)" "prognostic favorable (5.65e-7)" "unprognostic (1.83e-1)" "unprognostic (3.21e-2)" "unprognostic (1.67e-1)" "unprognostic (1.16e-2)" 11.6 10.2 10.6 13.3 13.4 24.3 14.0 24.5 12.5 13.3 9.4 11.4 11.6 9.9 9.6 16.5 10.2 12.0 21.9 9.6 9.5 14.9 12.1 13.6 17.1 13.6 9.4 12.0 9.3 21.1 9.4 10.1 14.0 19.5 12.1 114.1 12.1 10.9 19.3 18.2 12.1 13.6 7.8 16.1 12.8 3.2 10.0 16.8 14.5 24.4 15.0 11.0 15.3 16.8 12.2 2.4 2.4 3.8 15.3 23.9 9.0 14.5 24.2 13.0 8.5 2.8 14.8 12.0 7.9 48.2 6.1 5.2 4.4 14.1 13.0 7.2 3.4 8.9 6.3 1.9 7.9 22.6 15.7 13.2 15.4 12.7 68.6 8.9 14.2 7.5 7.8 6.2 29.5 3.8 17.8 6.7 0.4 9.6 3.9 19.7 16.5 4.5 8.3 2.6 3.4 3.2 20.4 10.7 4.6 3.9 1.9 12.2 25.7 16.7 9.6 19.9 10.4 11.5 3.1 7.5 11.5 10.2 6.1 7.8 4.9 7.3 3.8 5.6 4.4 4.3 4.7 4.0 5.4 4.2 7.0 4.4 16.2 2.4 9.2 2.4 8.1 2.9 10.6 13.4 24.5 12.5 9.6 9.5 13.6 9.4 14.0 7.8 10.0 16.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 23.8 0.0 0.0 0.0 0.0 7.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 17.3 1.2 0.0 0.0 0.0 0.0 0.0 0.0 9.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 7.4 0.0 0.0 0.0 0.0 HERC4 "DKFZP564G092, KIAA1593" ENSG00000148634 "HECT and RLD domain containing E3 ubiquitin protein ligase 4" Q5GLZ8 10 67921899-68075301 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Differentiation, Spermatogenesis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocyte precursor cells: 174.9;Oligodendrocytes: 209.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "BJ: 201.4;fHDF/TERT166: 226.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045453, HPA070301" Uncertain Supported "Nucleoli fibrillar center,Cytosol" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "Nucleoli fibrillar center" "HPA045453: AB_10961917, HPA070301: AB_2686247" "unprognostic (3.66e-2)" "unprognostic (6.31e-2)" "unprognostic (1.58e-1)" "unprognostic (2.30e-1)" "unprognostic (1.42e-1)" "unprognostic (4.23e-2)" "unprognostic (3.51e-2)" "unprognostic (1.01e-3)" "unprognostic (3.54e-1)" "unprognostic (8.57e-2)" "unprognostic (4.94e-3)" "unprognostic (2.25e-2)" "prognostic unfavorable (3.86e-5)" "unprognostic (1.17e-1)" "unprognostic (2.40e-1)" "unprognostic (3.98e-1)" "unprognostic (2.31e-2)" 13.9 19.6 18.2 14.4 18.9 10.9 14.3 19.5 23.5 15.2 15.3 14.1 13.8 14.9 14.0 14.5 13.4 13.3 13.6 20.6 22.4 13.7 16.6 13.9 21.0 19.4 19.7 15.3 11.1 12.0 14.1 16.5 19.4 12.2 15.9 13.9 11.5 11.4 13.5 13.4 14.6 15.6 18.1 18.2 11.6 14.2 21.1 15.2 13.1 12.3 19.4 16.2 14.3 26.7 75.4 30.4 16.7 28.5 47.5 63.9 15.5 201.4 125.5 75.5 47.6 17.5 35.3 29.7 14.3 226.7 40.6 40.9 21.1 28.9 102.0 17.6 9.2 13.7 51.3 12.2 22.6 17.3 21.3 30.2 33.8 39.3 34.4 89.1 47.5 15.0 14.9 14.3 117.4 35.2 11.3 19.9 9.9 15.8 49.0 15.3 7.6 8.2 32.3 23.7 8.7 9.4 66.1 26.4 26.5 37.6 15.4 20.1 65.0 38.2 17.5 94.7 31.9 8.7 11.2 17.8 67.7 32.3 13.6 10.8 5.0 6.6 3.9 4.1 5.0 3.4 4.1 4.5 5.7 3.4 4.1 4.2 6.7 5.2 4.1 1.6 5.6 3.7 18.2 18.9 19.5 23.5 20.6 22.4 19.4 19.7 19.4 18.1 21.1 26.7 29.8 48.1 29.3 127.0 41.0 50.3 33.7 27.2 26.2 50.1 29.1 16.6 23.0 14.3 24.1 18.4 43.8 29.3 38.7 78.7 7.9 19.5 66.4 44.3 45.4 30.9 22.1 32.4 170.2 12.2 40.8 30.3 34.1 70.9 30.4 31.3 28.5 24.5 23.6 53.8 148.8 29.9 26.4 42.9 23.3 47.4 26.8 30.9 17.8 149.9 36.0 18.9 40.2 174.9 209.2 38.6 52.3 19.2 17.4 42.6 37.8 24.9 25.5 45.8 6.6 33.2 28.1 25.2 12.4 23.4 60.9 15.6 40.9 38.5 21.9 48.5 HIF1AN "DKFZp762F1811, FIH1, FLJ20615, FLJ22027" ENSG00000166135 "Hypoxia inducible factor 1 subunit alpha inhibitor" Q9NWT6 10 100529072-100559998 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Dioxygenase, Oxidoreductase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 41.6;tongue: 40.8" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA048742, HPA065302, CAB069903" Supported Supported Nucleoplasm,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm Cytosol "CAB069903: AB_10000508, HPA048742: AB_2680507, HPA065302: AB_2685458" "unprognostic (4.07e-2)" "unprognostic (7.75e-2)" "unprognostic (2.35e-2)" "unprognostic (3.83e-2)" "unprognostic (1.67e-2)" "unprognostic (1.21e-1)" "unprognostic (8.07e-3)" "unprognostic (8.82e-2)" "unprognostic (2.54e-1)" "unprognostic (1.41e-3)" "unprognostic (1.54e-2)" "unprognostic (3.05e-2)" "unprognostic (3.01e-2)" "unprognostic (3.09e-2)" "unprognostic (9.92e-2)" "unprognostic (1.41e-1)" "unprognostic (3.24e-2)" 6.5 8.1 6.9 7.8 6.5 6.2 6.5 6.1 7.3 6.2 5.7 7.5 7.2 7.3 7.2 7.5 6.8 6.3 12.3 6.6 6.0 7.5 5.4 5.7 7.8 6.7 7.5 10.3 8.1 12.1 6.5 6.0 6.5 7.5 6.6 9.8 6.5 8.3 41.6 10.1 7.2 7.4 6.0 6.8 6.5 13.9 7.0 9.3 5.5 40.8 9.6 7.1 5.4 6.5 13.8 14.4 19.0 19.1 28.8 11.9 16.3 14.4 34.4 20.9 24.5 22.3 11.5 14.8 12.8 21.7 15.4 15.9 16.9 13.0 22.6 16.5 10.2 14.2 12.8 17.2 14.9 17.1 17.9 11.7 12.9 20.4 22.2 29.4 11.9 19.5 6.3 8.1 23.9 14.4 18.3 11.2 6.2 11.6 6.9 13.2 23.4 7.2 14.6 18.2 7.2 11.9 12.4 7.6 13.7 15.8 25.7 9.2 10.1 10.6 13.8 10.6 14.7 10.9 11.8 11.1 17.6 13.8 8.1 13.7 7.6 15.3 7.7 10.7 7.7 7.9 8.0 7.3 7.2 6.4 7.6 7.8 8.0 9.1 13.0 2.6 9.8 8.4 6.9 6.5 6.1 7.3 6.6 6.0 6.7 7.5 6.5 6.0 7.0 6.5 7.9 0.0 6.5 11.8 16.7 11.0 11.5 16.4 13.1 17.9 12.3 8.9 40.7 14.3 11.7 11.0 16.7 27.8 16.5 15.5 9.8 17.3 21.5 9.0 11.3 12.1 13.2 16.0 12.2 13.9 17.6 10.9 11.2 8.7 6.3 20.0 8.2 10.9 14.3 25.2 11.2 12.0 8.2 18.5 6.8 49.3 11.1 10.1 3.6 11.2 23.4 15.0 27.8 11.1 12.8 17.7 11.3 12.0 11.2 11.4 20.1 20.5 11.6 23.1 6.6 12.0 16.1 48.2 26.6 11.4 11.6 32.7 14.0 14.8 13.3 10.3 HIPK1 "KIAA0630, MGC26642, MGC33446, MGC33548, Myak, Nbak2" ENSG00000163349 "Homeodomain interacting protein kinase 1" Q86Z02 1 113929324-113977869 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 142.0" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MCF7: 176.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016664 Approved Supported Nucleoplasm,Centrosome,Cytosol NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 24: Non-specific - Transcription regulation" "Nucleoplasm, Cytosol" Centrosome "HPA016664: AB_1850725" "unprognostic (2.98e-1)" "unprognostic (3.94e-2)" "unprognostic (4.89e-3)" "unprognostic (2.52e-2)" "unprognostic (6.47e-2)" "unprognostic (9.84e-3)" "unprognostic (4.64e-3)" "unprognostic (7.22e-2)" "unprognostic (7.52e-2)" "unprognostic (1.45e-2)" "unprognostic (1.26e-1)" "unprognostic (1.15e-1)" "unprognostic (8.63e-2)" "unprognostic (1.84e-1)" "unprognostic (2.64e-1)" "unprognostic (1.94e-2)" "unprognostic (1.99e-2)" 19.8 20.0 24.7 20.2 23.5 142.0 16.8 44.5 20.9 24.4 42.4 19.0 12.7 18.1 17.2 23.1 35.0 22.2 18.0 20.6 32.5 18.2 17.8 23.4 20.9 37.2 39.4 22.8 21.8 21.3 20.5 17.7 29.8 15.4 18.9 56.5 15.2 17.7 25.7 23.4 16.8 18.2 36.9 20.7 17.8 47.1 27.5 57.4 29.8 27.1 20.6 19.7 18.8 25.6 23.4 18.8 25.4 19.5 29.2 15.2 17.1 15.8 19.0 22.2 20.9 21.8 8.8 31.4 21.2 25.3 8.2 15.5 33.1 18.6 31.7 23.0 16.7 45.8 23.7 23.0 24.3 36.7 54.2 16.5 26.5 28.3 28.7 20.8 33.2 54.2 31.8 32.8 32.1 176.4 48.8 21.0 26.2 17.1 15.8 29.1 74.4 10.9 19.8 19.9 11.2 15.0 28.9 30.6 20.5 27.9 17.7 52.3 32.6 21.5 29.0 35.3 24.3 20.1 17.2 26.7 23.7 29.3 50.3 2.1 2.5 5.0 3.0 2.1 3.0 0.9 2.7 2.8 1.7 1.1 2.6 3.3 5.8 2.7 1.6 3.7 2.0 1.5 24.7 23.5 44.5 20.9 20.6 32.5 37.2 39.4 29.8 36.9 27.5 25.6 30.1 54.5 37.2 14.4 26.0 61.4 16.2 16.7 15.4 57.7 29.8 20.2 34.6 22.8 24.5 27.6 70.9 10.7 125.8 38.9 5.9 14.6 95.2 147.9 33.4 28.9 37.2 64.4 27.4 21.0 10.3 24.3 20.9 47.0 46.9 26.3 21.8 37.4 22.2 74.0 33.9 25.4 12.2 49.5 77.7 101.4 22.1 50.2 21.4 31.9 43.1 30.6 36.0 21.1 26.5 18.8 22.4 37.2 43.5 33.7 17.8 16.4 116.4 64.8 26.3 36.5 44.3 49.7 31.5 25.6 80.6 14.2 69.7 21.9 28.3 32.7 HIPK2 ENSG00000064393 "Homeodomain interacting protein kinase 2" Q9H2X6 7 139561570-139777998 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Apoptosis, DNA damage, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 10 "brain: 397.5" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 463.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 7 "basophil: 27.5" "Lineage enriched" "Detected in many" 7 "granulocytes: 27.5" "Cell line enhanced" "Detected in many" "HDLM-2: 120.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007611 Supported Supported Nucleoplasm NA NA "Cluster 38: Basophils - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 44: HDLM-2 - Immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA007611: AB_1850730" "unprognostic (1.35e-3)" "unprognostic (1.49e-2)" "unprognostic (1.65e-1)" "unprognostic (7.65e-2)" "unprognostic (5.50e-2)" "unprognostic (9.44e-2)" "unprognostic (2.76e-1)" "unprognostic (4.66e-2)" "unprognostic (1.44e-1)" "unprognostic (2.76e-2)" "unprognostic (3.42e-3)" "unprognostic (4.58e-2)" "prognostic favorable (9.99e-4)" "unprognostic (1.38e-1)" "unprognostic (7.82e-2)" "unprognostic (3.93e-3)" "unprognostic (1.03e-2)" 19.8 9.2 253.4 6.9 359.7 15.0 10.3 124.8 187.0 4.3 39.4 6.6 7.4 6.0 4.1 9.2 8.8 4.7 30.3 146.3 235.5 25.5 14.9 10.7 4.1 253.8 268.7 5.5 11.5 11.5 8.9 10.1 192.5 9.3 4.8 27.8 12.1 5.7 23.5 3.0 6.3 3.9 187.4 6.9 14.5 1.9 318.3 6.9 9.3 17.0 4.2 6.0 5.2 397.5 11.7 51.4 23.2 14.3 55.2 39.4 2.7 6.4 6.3 7.0 7.3 3.8 6.3 0.0 14.3 12.1 43.2 0.6 10.7 16.6 17.5 120.9 4.3 53.7 8.7 18.4 31.0 14.9 14.0 60.3 10.5 32.4 47.9 16.5 17.6 10.0 31.7 14.4 54.3 8.9 18.9 10.6 5.9 6.6 34.3 22.1 12.7 1.6 31.5 2.0 14.1 12.9 14.4 0.5 7.0 4.3 7.9 6.0 59.5 24.5 11.6 28.5 31.4 68.7 44.3 10.2 49.4 7.7 13.4 27.5 1.3 3.5 0.2 1.1 0.3 0.6 0.5 0.2 0.6 0.5 1.6 0.5 1.7 0.2 4.1 0.2 0.1 0.7 253.4 359.7 124.8 187.0 146.3 235.5 253.8 268.7 192.5 187.4 318.3 397.5 107.8 16.0 31.2 82.6 45.8 9.3 30.6 24.9 16.5 116.0 65.6 32.6 213.9 55.8 35.6 64.4 152.2 8.8 72.0 38.4 35.2 32.5 3.1 39.1 12.2 80.3 67.2 18.5 17.8 67.0 1.5 28.1 70.8 41.7 44.9 24.3 151.0 145.2 15.7 222.1 36.3 32.2 63.1 119.5 10.9 4.0 13.1 53.2 44.4 49.6 47.6 78.0 95.8 145.3 463.7 63.4 24.6 18.8 97.9 118.9 22.5 75.0 48.7 62.9 46.0 96.6 60.8 2.7 4.8 42.5 9.5 9.6 30.5 20.1 29.3 43.9 HIPK3 "DYRK6, FIST3, PKY, YAK1" ENSG00000110422 "Homeodomain interacting protein kinase 3" Q9H422 11 33256672-33357023 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA028069 Approved Supported "Nuclear bodies,Cytosol" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Cytosol "Nuclear bodies" "HPA028069: AB_10601815" "unprognostic (2.41e-3)" "unprognostic (1.02e-1)" "unprognostic (4.61e-1)" "unprognostic (5.74e-2)" "unprognostic (2.09e-1)" "unprognostic (1.78e-2)" "unprognostic (1.63e-1)" "unprognostic (7.29e-2)" "unprognostic (1.61e-1)" "unprognostic (2.78e-1)" "unprognostic (2.18e-1)" "unprognostic (2.68e-1)" "unprognostic (3.29e-3)" "unprognostic (7.89e-3)" "unprognostic (1.80e-1)" "unprognostic (1.87e-1)" "unprognostic (2.48e-2)" 57.8 21.5 29.5 25.3 31.5 23.3 35.1 32.9 23.4 27.6 75.9 30.7 16.7 33.1 24.2 30.9 31.7 30.6 53.7 19.9 42.1 38.2 29.8 26.9 22.8 35.5 36.2 27.2 25.8 46.7 12.8 34.7 27.8 23.3 20.6 22.4 22.9 26.1 69.0 22.3 20.2 39.3 34.2 30.6 22.1 18.9 43.1 25.5 33.7 85.3 24.7 32.3 22.4 33.0 19.3 18.0 13.4 15.1 60.5 37.9 12.9 20.0 23.1 15.9 13.3 19.9 13.8 20.7 16.3 24.4 8.0 24.3 10.2 22.2 22.1 30.8 15.8 21.0 20.3 15.2 25.0 22.9 12.8 35.8 42.8 6.1 17.7 16.5 19.4 14.8 6.4 40.4 26.0 10.1 19.2 15.8 3.4 17.3 11.1 25.4 47.3 19.9 26.4 29.4 2.0 11.3 27.1 30.7 18.7 14.2 34.6 41.2 25.8 24.8 16.9 28.9 14.6 21.7 37.2 21.4 11.9 23.5 23.7 10.6 12.7 6.1 4.0 9.4 5.0 2.8 3.6 4.3 14.0 3.3 3.2 4.0 21.1 4.4 11.1 1.7 4.0 5.0 29.5 31.5 32.9 23.4 19.9 42.1 35.5 36.2 27.8 34.2 43.1 33.0 122.2 12.8 44.7 46.0 29.6 66.5 42.8 21.3 39.3 16.2 35.8 25.8 159.9 37.1 32.9 33.1 18.8 18.6 31.2 32.7 5.9 13.0 21.8 76.5 80.5 96.5 37.1 20.6 44.9 24.9 13.4 59.2 23.0 49.0 14.5 24.3 57.5 53.2 30.7 32.0 48.0 28.4 12.2 102.0 76.0 26.1 42.9 68.1 58.7 73.1 69.1 16.2 25.7 45.8 69.1 21.5 21.1 37.6 24.9 52.6 40.7 35.0 65.4 24.9 52.6 83.4 56.4 10.7 8.1 33.4 75.0 15.5 29.8 12.5 25.2 51.2 HLTF "HIP116A, HLTF1, RNF80, SMARCA3, SNF2L3" ENSG00000071794 "Helicase like transcription factor" Q14527 3 149030127-149086554 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Ubl conjugation pathway" "Activator, Chromatin regulator, DNA-binding, Helicase, Hydrolase, Multifunctional enzyme, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 143.4;Spermatogonia: 113.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015284, HPA049001" Uncertain Enhanced Nucleoplasm NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 21: Non-specific - Transcription" "Cluster 6: T47d - Mammary gland" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Nucleoplasm "HPA015284: AB_1857263, HPA049001: AB_2680594" "unprognostic (3.21e-2)" "unprognostic (3.46e-2)" "unprognostic (6.81e-2)" "unprognostic (1.95e-3)" "unprognostic (4.29e-1)" "unprognostic (1.29e-1)" "prognostic unfavorable (7.27e-4)" "unprognostic (3.01e-2)" "unprognostic (2.13e-2)" "unprognostic (2.27e-1)" "unprognostic (4.78e-2)" "unprognostic (9.00e-3)" "unprognostic (1.39e-1)" "unprognostic (2.94e-1)" "unprognostic (3.42e-1)" "unprognostic (2.83e-2)" "unprognostic (1.07e-2)" 12.2 23.6 10.3 7.4 11.9 11.5 13.8 20.7 12.0 11.1 17.6 9.9 5.3 13.6 10.2 7.5 11.5 9.3 19.0 10.3 13.4 16.9 18.5 7.8 11.9 13.1 12.6 18.8 13.6 17.2 12.4 8.2 13.9 15.7 7.5 27.6 11.1 11.6 11.6 5.6 6.8 12.1 15.1 8.7 9.9 44.7 12.2 15.8 21.0 11.4 11.2 8.3 6.0 17.5 66.7 31.8 44.3 34.6 29.0 37.3 4.3 44.1 26.2 32.0 37.0 25.8 45.1 42.7 52.3 20.6 62.3 1.9 60.1 17.5 52.9 23.7 29.1 102.6 23.6 10.5 18.1 27.2 40.7 23.7 9.3 23.9 13.9 48.4 18.7 68.1 36.5 26.9 44.2 33.5 56.4 40.9 33.5 33.3 39.3 64.2 49.8 6.6 26.2 21.1 43.5 25.6 66.9 30.4 60.8 23.3 91.5 25.9 13.2 37.1 22.4 53.1 48.5 39.3 23.5 55.4 36.2 36.3 14.6 8.2 1.0 3.5 4.3 1.7 8.0 6.9 3.8 5.8 3.4 4.9 5.6 5.7 0.0 4.7 1.9 7.8 3.9 2.8 10.3 11.9 20.7 12.0 10.3 13.4 13.1 12.6 13.9 15.1 12.2 17.5 19.5 25.6 20.4 56.8 15.6 5.6 8.5 12.9 10.8 99.3 20.1 16.5 46.4 18.6 18.5 31.3 41.7 10.2 29.9 1.9 35.2 10.1 9.9 36.7 31.1 14.3 4.9 71.5 67.5 8.4 10.1 27.6 12.8 11.7 55.7 55.8 13.2 17.2 8.7 47.1 88.7 6.9 18.3 4.6 3.1 12.3 33.8 11.9 5.4 28.1 5.2 35.4 12.3 66.4 68.7 7.4 3.6 32.4 19.3 8.2 2.0 19.2 26.2 76.2 13.1 37.5 23.8 143.4 113.2 11.5 4.3 1.6 22.1 100.6 7.5 6.6 HUNK ENSG00000142149 "Hormonally up-regulated Neu-associated kinase" P57058 21 31873020-32044633 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pancreas: 9.8" "Cell type enriched" "Detected in many" 5 "Inhibitory neurons: 109.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 13.2;BEWO: 16.3;RH-30: 18.1;SCLC-21H: 14.8;SiHa: 13.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA027295, HPA027372" Approved Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 29: Non-specific - Vesicular transport" "Cluster 28: BEWO - Transcription regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Plasma membrane" "HPA027295: AB_2672203, HPA027372: AB_2672239" "unprognostic (9.09e-3)" "unprognostic (7.29e-2)" "unprognostic (1.42e-1)" "unprognostic (5.95e-3)" "unprognostic (1.99e-1)" "unprognostic (2.12e-4)" "unprognostic (4.00e-2)" "unprognostic (6.90e-2)" "unprognostic (5.07e-1)" "unprognostic (2.27e-1)" "unprognostic (9.09e-2)" "unprognostic (1.13e-1)" "prognostic favorable (7.48e-5)" "unprognostic (8.84e-2)" "unprognostic (2.22e-1)" "unprognostic (1.39e-1)" "unprognostic (6.69e-2)" 0.7 1.0 0.8 1.3 1.3 0.2 1.2 0.4 4.7 0.4 0.0 3.6 1.4 4.1 1.9 0.4 1.9 0.5 0.4 4.2 2.6 3.7 0.5 0.9 0.4 0.4 0.1 0.6 9.8 0.1 1.1 4.6 0.1 0.9 3.7 3.0 0.6 2.1 0.3 3.0 2.7 2.4 0.0 0.1 1.3 0.9 0.2 0.7 0.6 0.2 0.6 1.5 0.7 1.6 0.0 3.9 13.2 0.1 0.0 0.0 16.3 1.3 0.0 0.2 0.0 5.3 0.1 0.0 0.5 6.2 0.2 0.0 7.7 0.0 0.1 0.1 3.9 0.0 3.7 2.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 4.7 0.0 0.0 0.0 1.1 0.2 1.1 10.2 0.1 0.1 0.1 18.1 0.1 1.3 0.0 14.8 9.8 13.2 1.0 0.5 9.3 5.5 1.4 0.0 0.1 9.3 0.1 0.0 0.1 0.0 1.8 0.0 0.0 6.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.8 1.3 0.4 4.7 4.2 2.6 0.4 0.1 0.1 0.0 0.2 1.6 0.2 6.4 9.1 7.5 0.0 5.1 2.6 0.2 0.6 8.1 0.5 2.8 3.5 14.3 3.0 7.3 2.1 9.2 0.0 4.6 0.0 5.3 0.2 1.2 1.3 0.8 4.9 0.0 19.0 3.3 13.9 7.9 0.5 3.4 0.0 4.3 0.4 1.0 2.7 3.3 109.6 5.1 0.0 0.0 4.2 0.1 0.3 0.4 3.6 1.0 0.1 8.1 0.0 10.1 1.5 1.6 4.4 0.0 0.0 2.1 1.8 1.9 0.8 1.2 0.0 6.3 2.2 0.7 1.1 0.7 5.8 6.2 0.5 0.0 10.6 0.9 HUWE1 "Ib772, KIAA0312, UREB1" ENSG00000086758 "HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1" Q7Z6Z7 X 53532096-53686728 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Biological rhythms, Differentiation, DNA damage, DNA repair, Ubl conjugation pathway" "DNA-binding, Transferase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in all" 4 "Granulosa cells: 507.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002548, CAB022718" Approved Enhanced Nucleoplasm,Cytosol NA NA 73000 "Cluster 27: Non-specific - Gene expression" "Cluster 80: Striated muscle - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 40: Granulosa cells - Unknown function" "Nucleoplasm, Cytosol" "CAB022718: , HPA002548: AB_1080489" "unprognostic (4.73e-2)" "unprognostic (9.06e-2)" "unprognostic (1.31e-1)" "unprognostic (1.59e-2)" "unprognostic (6.64e-2)" "unprognostic (3.16e-2)" "unprognostic (1.33e-2)" "unprognostic (2.21e-1)" "unprognostic (3.56e-1)" "unprognostic (5.51e-2)" "unprognostic (1.33e-1)" "unprognostic (8.89e-2)" "unprognostic (8.10e-3)" "unprognostic (2.17e-1)" "unprognostic (1.32e-1)" "unprognostic (3.67e-2)" "unprognostic (2.45e-1)" 37.7 46.1 55.6 21.1 57.4 26.7 37.4 57.6 69.6 39.8 42.0 49.4 17.6 45.6 52.6 48.4 40.7 18.5 57.1 62.6 61.3 45.2 41.8 36.1 26.6 58.7 67.8 54.0 45.9 43.2 54.2 24.0 73.2 38.4 22.7 40.0 38.9 28.6 101.0 59.3 40.2 28.8 49.1 42.5 45.5 43.0 65.1 41.2 42.9 58.1 30.3 44.6 40.2 57.2 166.8 100.4 64.0 45.4 109.2 64.8 78.5 48.8 62.6 50.2 52.3 77.0 52.2 86.6 32.3 89.4 90.4 77.8 145.6 81.8 68.3 125.6 64.6 69.1 91.9 60.5 100.2 104.5 40.6 62.4 59.8 120.8 137.6 49.7 88.3 66.4 70.3 54.5 66.3 102.4 57.0 58.2 87.7 45.4 71.3 52.0 87.9 52.8 84.0 113.3 53.1 38.4 137.7 60.5 44.1 118.7 87.0 50.1 113.8 46.0 65.8 66.5 62.9 47.3 50.2 73.1 49.2 100.1 67.6 2.8 2.3 4.3 3.3 1.9 4.0 2.4 3.1 3.5 3.3 2.4 2.2 2.2 1.9 3.5 3.8 3.5 2.9 1.9 55.6 57.4 57.6 69.6 62.6 61.3 58.7 67.8 73.2 49.1 65.1 57.2 41.4 51.3 46.1 70.2 41.9 30.1 32.6 30.4 44.9 57.8 37.0 35.6 110.4 37.1 35.4 40.5 50.1 31.0 40.0 29.2 1.9 42.8 28.6 45.6 59.8 38.3 47.6 47.7 94.4 35.4 34.8 38.6 57.1 69.6 22.1 507.7 32.9 48.1 24.8 82.4 85.8 28.1 18.3 31.4 30.8 32.8 28.3 34.1 26.6 59.0 43.7 22.6 35.0 83.9 95.3 49.3 20.5 39.1 50.9 44.1 27.1 14.7 35.7 33.3 13.1 69.6 56.4 34.5 44.6 53.3 41.6 37.9 46.7 114.1 31.7 42.0 HYKK "AGPHD1, LOC123688" ENSG00000188266 "Hydroxylysine kinase" A2RU49 15 78507564-78537372 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal tubular cells: 29.4;Late spermatids: 33.7;Proximal enterocytes: 37.0;Proximal tubular cells: 39.4;Skeletal myocytes: 28.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "naive CD4 T-cell: 3.0" "Lineage enriched" "Detected in single" 6 "T-cells: 3.0" "Cell line enhanced" "Detected in many" "HEK 293: 22.2;U-266/84: 24.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA040706 Approved Approved Vesicles,Aggresome NA NA "Cluster 32: T-cells - Unknown function" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Vesicles Aggresome "HPA040706: AB_10795528" "unprognostic (9.26e-2)" "unprognostic (1.98e-4)" "unprognostic (7.84e-2)" "unprognostic (3.16e-2)" "unprognostic (3.64e-1)" "unprognostic (2.72e-2)" "unprognostic (1.14e-1)" "unprognostic (8.00e-3)" "unprognostic (2.73e-1)" "unprognostic (5.16e-2)" "unprognostic (6.24e-3)" "unprognostic (6.37e-2)" "unprognostic (3.44e-3)" "unprognostic (2.19e-1)" "unprognostic (1.04e-1)" "unprognostic (3.11e-3)" "unprognostic (3.90e-2)" 4.5 4.8 2.8 1.0 3.1 1.3 4.5 2.2 3.2 5.6 1.6 4.6 7.3 3.8 5.9 2.8 4.3 2.4 5.3 2.7 2.2 12.3 5.7 2.1 2.0 2.0 2.0 6.1 6.8 4.8 3.5 0.7 1.8 4.1 3.4 2.6 3.5 4.1 6.2 2.8 7.2 3.6 1.6 1.3 5.1 5.3 2.3 1.9 4.5 5.4 1.7 3.9 3.8 2.9 4.3 6.3 1.0 11.3 2.3 5.3 2.7 1.5 2.7 3.7 4.2 2.2 4.9 3.1 1.4 2.5 6.3 5.2 10.0 3.3 3.5 1.5 22.2 1.7 3.8 5.6 6.0 0.5 1.9 4.8 6.4 1.4 2.7 1.8 2.7 13.8 4.0 8.4 2.2 5.0 4.2 1.0 0.7 9.8 8.3 2.4 12.4 2.7 7.1 5.1 1.3 1.6 2.9 8.6 10.9 1.9 9.5 0.4 1.9 2.4 1.8 4.3 4.4 12.9 24.2 0.2 3.2 0.2 3.4 0.4 0.1 0.2 0.1 0.0 0.1 0.1 1.1 0.1 0.0 0.1 3.0 0.6 0.3 0.1 0.0 0.3 0.5 0.4 2.8 3.1 2.2 3.2 2.7 2.2 2.0 2.0 1.8 1.6 2.3 2.9 4.1 12.8 4.1 4.6 1.4 3.6 7.7 4.5 6.2 2.0 4.5 9.8 6.7 0.0 2.9 7.3 2.1 7.3 1.5 2.8 29.4 2.5 14.0 2.7 3.3 4.1 4.2 1.3 2.8 7.9 4.4 5.4 5.1 1.5 0.0 2.4 6.8 7.1 0.8 0.0 2.7 3.9 2.0 1.0 0.9 33.7 5.3 1.0 7.2 2.8 0.3 7.5 0.0 0.5 1.1 2.9 3.6 3.8 1.7 3.7 37.0 39.4 3.5 1.9 0.0 28.1 4.0 5.4 8.0 4.9 1.6 3.4 1.6 3.9 5.7 4.7 IKBKB "IKK-beta, IKK2, IKKB, NFKBIKB" ENSG00000104365 "Inhibitor of nuclear factor kappa B kinase subunit beta" O14920 8 42271302-42332460 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" "Host-virus interaction" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets, SCID" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 135.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001249, CAB004447" Enhanced Supported Cytosol NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 9: Photoreceptor cells - Phototransduction" Cytosol "CAB004447: AB_627785, HPA001249: AB_1079126" "unprognostic (1.04e-1)" "unprognostic (2.30e-2)" "unprognostic (1.31e-1)" "unprognostic (1.73e-3)" "unprognostic (1.26e-1)" "unprognostic (1.27e-3)" "unprognostic (1.95e-1)" "unprognostic (1.25e-3)" "unprognostic (1.75e-1)" "unprognostic (1.55e-1)" "unprognostic (3.27e-1)" "unprognostic (1.73e-1)" "unprognostic (1.20e-2)" "unprognostic (1.89e-2)" "unprognostic (9.20e-2)" "unprognostic (3.02e-1)" "prognostic favorable (1.46e-6)" 9.4 8.2 9.1 4.7 9.8 4.8 8.3 9.2 10.9 7.2 11.7 6.8 4.8 8.1 7.3 10.2 11.6 8.6 5.6 9.2 9.5 6.8 6.6 11.3 12.2 10.5 9.9 6.1 6.2 13.5 4.0 8.2 10.0 7.9 6.8 12.3 8.9 9.3 13.7 11.4 4.9 12.7 9.7 10.5 5.5 3.2 10.1 10.8 9.4 24.3 11.6 11.1 6.8 10.2 6.2 15.7 8.0 13.6 17.3 18.9 5.8 9.2 18.2 15.2 17.2 3.1 13.9 14.1 10.0 16.5 12.5 5.6 8.4 18.3 17.8 9.8 10.8 17.8 7.8 5.9 20.9 6.1 24.0 12.3 13.7 15.0 19.1 36.1 20.7 11.6 12.8 6.9 34.6 5.1 13.9 11.3 6.1 18.9 6.0 11.1 15.3 10.0 19.6 5.7 1.3 4.7 6.4 6.4 11.7 10.0 8.7 23.6 13.6 7.2 3.9 13.9 6.1 2.8 4.0 10.3 13.8 7.6 16.7 7.4 5.0 5.6 4.6 4.1 4.3 4.4 5.1 5.5 3.7 4.8 4.8 4.7 5.2 5.1 5.5 8.5 5.9 2.9 9.1 9.8 9.2 10.9 9.2 9.5 10.5 9.9 10.0 9.7 10.1 10.2 31.3 12.8 26.9 19.2 28.4 24.3 34.1 13.9 25.6 12.7 20.6 15.5 8.8 14.3 15.4 16.5 135.5 10.4 34.1 15.9 1.9 13.4 2.3 13.9 15.6 27.4 11.4 10.1 19.7 13.6 5.3 12.4 21.9 16.5 38.0 24.0 19.6 12.0 18.6 18.5 20.6 16.4 8.2 32.3 24.0 3.4 16.4 23.4 19.6 58.1 33.7 8.7 47.4 17.1 30.2 16.6 15.0 12.8 18.2 31.9 13.2 5.5 20.2 47.9 6.6 13.1 11.4 4.8 7.0 17.8 29.1 15.2 24.3 6.2 14.1 30.8 IKBKE "IKK-i, IKKE, KIAA0151" ENSG00000263528 "Inhibitor of nuclear factor kappa B kinase subunit epsilon" Q14164 1 206470476-206496889 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, Host-virus interaction" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 24.3" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 37.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "NB-4: 47.7" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA015788, CAB025983" Approved Supported Cytosol NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 24: NB-4 - Immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Cytosol "CAB025983: , HPA015788: AB_1851566" "unprognostic (6.43e-2)" "unprognostic (3.04e-1)" "unprognostic (1.48e-1)" "unprognostic (5.76e-2)" "unprognostic (7.78e-3)" "unprognostic (7.37e-3)" "unprognostic (1.99e-3)" "unprognostic (2.82e-1)" "unprognostic (5.09e-3)" "unprognostic (1.30e-1)" "unprognostic (1.50e-1)" "unprognostic (1.27e-1)" "prognostic unfavorable (5.34e-7)" "unprognostic (1.48e-2)" "unprognostic (5.77e-2)" "unprognostic (2.84e-3)" "unprognostic (2.84e-2)" 2.4 3.7 2.6 16.7 4.6 8.7 3.1 2.0 3.2 4.1 1.9 7.8 7.4 1.7 3.9 14.6 2.8 5.1 1.4 2.7 3.3 3.4 1.6 4.1 24.3 4.1 3.6 1.2 3.4 1.0 1.9 2.6 3.9 3.6 7.7 0.1 6.9 2.1 0.5 15.0 8.0 2.5 2.7 14.2 7.2 0.7 4.4 16.5 4.5 0.3 20.4 8.4 6.8 4.6 17.8 13.9 3.7 0.4 6.7 9.2 3.9 7.1 22.3 9.4 10.4 11.5 26.9 35.3 18.6 14.5 11.5 23.0 0.1 18.1 2.2 5.5 3.5 4.7 8.8 7.6 8.4 29.5 14.8 12.2 3.2 7.7 1.7 10.9 14.2 9.4 2.3 10.0 10.5 3.6 19.2 47.7 5.2 4.3 10.9 9.7 4.3 27.7 10.7 29.4 0.0 0.0 2.9 22.9 4.2 4.5 13.8 20.3 26.5 9.0 5.5 6.9 8.5 3.5 1.8 23.3 17.1 24.2 3.7 12.2 32.8 0.6 21.2 23.3 14.8 26.4 32.4 30.1 9.5 14.0 25.7 27.3 2.2 23.9 13.4 3.2 52.8 28.6 2.6 4.6 2.0 3.2 2.7 3.3 4.1 3.6 3.9 2.7 4.4 4.6 0.4 0.0 4.5 0.7 13.7 1.9 3.6 37.8 1.8 0.0 4.3 3.7 0.9 4.3 16.3 0.0 0.0 4.2 7.9 11.7 0.0 12.1 3.3 1.5 0.9 0.7 3.6 4.4 1.5 12.6 5.2 3.4 17.3 2.4 5.1 3.7 2.2 0.8 13.8 0.0 1.5 6.4 8.2 12.9 0.7 7.0 0.9 16.0 7.2 1.9 9.0 0.0 14.4 1.0 0.2 15.9 21.5 0.7 6.4 3.2 10.7 3.5 14.5 0.0 0.0 0.7 3.1 0.3 0.9 11.1 4.8 1.5 15.8 3.9 10.2 11.6 ILK ENSG00000166333 "Integrin linked kinase" Q13418 11 6603708-6610874 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004041, HPA048437" Enhanced Supported "Nucleoplasm,Plasma membrane,Focal adhesion sites" NA NA 30000000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 51: Myeloid cells - Hemostasis" "Plasma membrane, Focal adhesion sites" Nucleoplasm "CAB004041: AB_2127050, HPA048437: AB_2680391" "unprognostic (1.78e-1)" "unprognostic (2.26e-2)" "unprognostic (5.26e-2)" "unprognostic (2.12e-2)" "unprognostic (7.57e-2)" "unprognostic (1.01e-1)" "unprognostic (6.19e-3)" "unprognostic (5.25e-3)" "unprognostic (1.49e-2)" "unprognostic (9.65e-2)" "unprognostic (2.64e-1)" "unprognostic (8.12e-2)" "prognostic favorable (2.44e-4)" "unprognostic (4.01e-3)" "unprognostic (9.27e-2)" "unprognostic (2.42e-1)" "unprognostic (6.36e-3)" 108.0 77.2 49.8 85.1 52.4 43.7 91.8 51.7 50.6 151.6 55.0 398.2 66.4 359.1 81.8 115.5 164.2 88.0 175.9 47.4 50.7 78.8 65.9 107.9 72.4 51.8 50.6 101.0 89.3 73.2 47.1 98.8 50.9 182.7 116.8 28.3 69.5 412.2 90.8 61.5 117.4 364.7 51.1 95.5 149.7 26.5 53.7 45.8 72.0 92.0 70.5 226.7 118.8 51.9 127.8 94.4 148.9 51.8 224.8 159.4 67.2 182.2 360.0 211.9 256.0 102.7 145.7 47.0 47.0 304.1 206.9 99.5 84.4 155.6 213.0 83.5 74.3 69.1 84.9 82.8 150.8 55.9 74.7 153.2 72.8 143.8 108.9 217.7 206.9 40.5 63.7 55.0 282.8 97.1 49.4 97.4 94.3 107.5 110.8 51.0 77.8 50.5 160.3 100.8 25.6 57.4 86.0 118.4 103.6 144.0 82.2 62.2 238.8 263.9 118.0 111.1 90.7 38.9 25.9 67.1 195.6 82.8 125.3 314.9 260.0 417.6 127.3 258.1 124.9 96.9 114.4 122.3 242.7 92.9 70.2 88.5 165.5 257.8 254.8 98.5 142.8 402.8 49.8 52.4 51.7 50.6 47.4 50.7 51.8 50.6 50.9 51.1 53.7 51.9 79.5 44.8 17.9 24.2 33.6 50.5 73.7 100.6 24.5 21.5 43.1 68.2 0.5 70.1 49.7 57.0 8.4 119.8 46.0 71.9 58.7 136.1 64.6 33.2 78.1 69.4 37.9 53.7 14.6 125.0 177.7 83.2 50.4 52.5 30.4 41.6 76.4 31.4 127.4 8.4 17.1 50.1 69.2 51.5 97.7 143.7 71.4 115.9 85.4 30.9 143.0 54.3 77.2 15.6 15.3 117.1 60.0 147.4 35.1 42.0 74.5 98.6 31.0 32.9 157.8 53.3 165.8 31.7 17.1 32.3 43.2 110.0 49.3 65.0 50.1 43.9 ILKAP "DKFZP434J2031, FLJ10181, PPM1O" ENSG00000132323 "ILK associated serine/threonine phosphatase" Q9H0C8 2 238170402-238203708 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004752, HPA056099" Uncertain Supported Nucleoplasm NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 80: Striated muscle - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA004752: AB_1851753, HPA056099: AB_2797255" "unprognostic (1.50e-1)" "unprognostic (1.62e-1)" "unprognostic (1.23e-1)" "unprognostic (1.03e-1)" "unprognostic (6.78e-2)" "unprognostic (9.75e-2)" "prognostic unfavorable (1.04e-4)" "unprognostic (1.60e-1)" "unprognostic (3.07e-2)" "unprognostic (3.88e-2)" "unprognostic (1.37e-3)" "unprognostic (7.03e-2)" "prognostic unfavorable (9.89e-6)" "unprognostic (6.24e-2)" "unprognostic (6.63e-2)" "unprognostic (2.63e-2)" "unprognostic (1.20e-1)" 20.5 17.4 24.3 15.1 25.6 29.0 19.5 26.5 26.9 26.2 22.3 30.8 14.6 25.1 15.3 23.2 23.4 8.7 24.2 23.8 24.9 26.0 26.2 18.6 20.5 24.9 24.2 24.5 20.6 13.1 26.5 12.9 24.1 25.2 12.9 13.0 17.3 14.5 41.4 22.4 23.3 16.1 23.9 25.9 21.4 23.1 24.6 17.9 23.9 18.3 18.1 26.6 21.8 27.4 40.5 25.6 36.9 36.3 28.1 18.6 37.9 41.5 27.9 40.9 35.4 23.7 20.9 25.8 10.5 30.1 48.8 33.8 48.1 34.4 41.2 46.6 49.8 66.7 26.0 52.7 43.3 43.7 50.3 19.6 23.3 43.6 43.6 20.2 31.1 34.0 52.4 16.1 35.4 48.1 43.4 58.0 34.8 37.4 25.9 52.6 75.6 23.7 30.4 18.8 54.1 26.7 28.2 29.6 68.9 27.9 23.3 43.7 28.9 39.7 36.7 53.5 45.1 28.6 31.4 46.7 32.5 47.3 34.3 43.4 19.8 27.1 28.2 25.6 25.4 24.7 24.9 26.4 27.7 24.0 28.8 22.9 7.3 24.8 21.4 20.9 30.7 23.0 24.3 25.6 26.5 26.9 23.8 24.9 24.9 24.2 24.1 23.9 24.6 27.4 27.7 12.8 22.0 43.8 35.4 27.0 29.1 30.8 25.0 28.9 19.4 21.6 23.1 17.2 19.6 25.8 29.2 41.2 51.5 22.4 43.0 27.9 8.1 17.1 20.6 21.5 19.1 64.2 37.7 28.5 43.7 26.7 29.0 16.1 33.7 43.5 22.1 19.2 34.4 38.7 33.2 24.0 16.2 17.0 22.0 12.6 28.3 24.0 30.2 25.3 34.0 25.1 57.7 36.7 72.2 24.8 16.2 29.3 33.6 29.7 24.1 33.4 19.3 28.6 32.9 29.2 47.4 54.4 70.8 29.2 28.7 40.4 36.6 23.0 27.4 23.5 IRAK1 "IRAK, pelle" ENSG00000184216 "Interleukin 1 receptor associated kinase 1" P51617 X 154010506-154019902 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction, Immunity, Innate immunity" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Exocrine glandular cells: 113.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004461, HPA054476" Supported Supported Nucleoplasm,Cytosol No No "Cluster 15: NK-cells - Transcription" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 1: Pancreatic cells - Digestion" Cytosol Nucleoplasm "CAB004461: AB_2249106, HPA054476: AB_2682501" "unprognostic (4.46e-3)" "unprognostic (9.32e-2)" "unprognostic (1.71e-2)" "unprognostic (5.04e-3)" "unprognostic (7.09e-3)" "unprognostic (4.43e-3)" "prognostic unfavorable (3.03e-4)" "unprognostic (7.89e-3)" "unprognostic (3.36e-2)" "unprognostic (3.69e-2)" "unprognostic (1.95e-1)" "unprognostic (6.64e-2)" "prognostic unfavorable (2.06e-4)" "unprognostic (2.76e-3)" "unprognostic (2.36e-1)" "unprognostic (2.21e-3)" "unprognostic (3.04e-1)" 48.6 61.2 24.4 37.6 25.3 82.4 40.7 23.6 34.9 29.0 20.0 41.4 43.3 31.8 7.7 69.1 28.8 20.2 34.4 22.3 26.5 44.2 64.7 48.9 33.7 38.1 30.0 28.9 84.9 12.4 37.5 17.8 30.8 46.1 15.0 4.5 41.6 21.0 92.5 44.3 51.1 16.4 29.6 69.9 41.9 20.8 34.3 19.4 24.5 16.8 24.0 47.7 36.5 29.4 467.2 178.9 24.5 201.2 48.4 38.5 108.3 68.8 64.5 104.0 96.0 142.3 199.4 200.8 371.4 73.6 157.6 124.3 57.6 112.4 39.8 156.7 173.4 73.3 158.6 85.7 110.8 174.2 118.7 53.2 96.1 99.0 107.8 53.2 62.8 39.6 130.9 220.3 73.3 171.4 70.8 152.1 60.9 148.4 353.5 181.6 126.4 334.7 68.5 86.3 137.4 98.7 82.2 88.6 135.2 9.5 34.3 179.2 86.4 123.8 194.6 284.6 424.2 274.8 190.6 358.2 179.6 205.1 130.8 1.3 7.2 6.2 5.3 9.2 4.7 6.5 4.3 4.4 4.8 7.9 2.5 4.7 5.2 5.4 7.5 10.9 2.3 3.3 24.4 25.3 23.6 34.9 22.3 26.5 38.1 30.0 30.8 29.6 34.3 29.4 20.2 0.0 13.3 5.9 29.7 13.4 14.5 10.9 5.2 9.1 23.9 19.0 9.3 18.6 16.0 11.0 6.2 11.4 33.0 41.4 7.9 40.5 0.9 9.8 13.5 18.1 20.4 18.1 9.7 113.6 20.9 15.2 18.3 17.3 12.7 25.5 13.2 35.9 57.2 16.8 8.9 27.2 0.0 51.4 24.7 3.8 18.0 43.0 14.2 11.2 24.2 21.8 13.4 4.5 6.6 75.0 28.6 21.4 33.5 30.0 39.4 19.6 10.0 5.3 0.0 14.5 14.9 1.6 8.1 15.1 13.1 12.3 19.6 18.4 39.4 25.3 IRAK2 ENSG00000134070 "Interleukin 1 receptor associated kinase 2" O43187 3 10164919-10243745 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 23.3" "Cell type enhanced" "Detected in many" "Langerhans cells: 43.7;Oligodendrocytes: 34.3;Prostatic glandular cells: 23.4;Urothelial cells: 30.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BEWO: 33.2;BJ hTERT+: 35.2;CAPAN-2: 35.6;GAMG: 62.6;RT4: 49.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013483, HPA050520" Uncertain Approved Vesicles NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 41: Macrophages - Immune response" Vesicles "CAB013483: , HPA050520: AB_2681154" "unprognostic (1.31e-1)" "unprognostic (2.04e-2)" "unprognostic (1.46e-2)" "unprognostic (4.61e-3)" "unprognostic (8.71e-2)" "unprognostic (9.55e-2)" "prognostic unfavorable (8.35e-4)" "unprognostic (1.89e-2)" "unprognostic (8.01e-2)" "unprognostic (1.24e-1)" "prognostic unfavorable (2.26e-4)" "unprognostic (2.24e-1)" "unprognostic (3.10e-2)" "unprognostic (7.22e-2)" "unprognostic (4.38e-2)" "unprognostic (3.91e-2)" "prognostic favorable (6.60e-5)" 6.4 3.6 4.0 6.0 3.9 23.3 4.6 3.9 8.0 2.9 1.7 2.1 2.0 2.0 0.7 7.2 1.8 4.4 1.9 3.2 5.1 3.4 10.8 10.4 3.8 5.1 4.1 1.0 1.9 1.0 1.2 2.2 5.6 3.3 1.7 1.5 3.6 1.8 17.0 5.2 5.4 1.4 3.4 4.5 3.4 1.3 4.2 3.9 3.1 4.3 11.5 16.1 4.5 8.0 2.7 7.6 0.3 1.0 8.1 6.7 33.2 2.9 35.2 4.7 4.5 3.6 35.6 0.1 0.9 4.3 62.6 0.8 0.8 9.0 6.3 2.3 2.5 0.8 1.7 9.9 3.9 0.0 1.1 4.1 1.5 17.3 22.4 12.4 9.7 0.3 1.8 10.7 5.7 0.1 0.0 1.8 0.3 4.2 7.5 1.7 0.0 0.6 10.3 49.2 0.5 0.3 3.3 0.1 0.3 0.8 0.8 1.7 10.1 10.7 0.9 6.5 7.0 3.6 11.3 2.1 22.9 4.7 1.9 0.2 1.0 0.1 5.8 0.7 6.0 4.2 1.7 3.3 1.0 3.2 1.2 3.0 2.1 7.4 0.2 0.0 0.7 2.2 4.0 3.9 3.9 8.0 3.2 5.1 5.1 4.1 5.6 3.4 4.2 8.0 3.9 0.0 4.1 1.6 8.3 8.0 20.8 9.9 5.2 0.9 1.6 1.3 2.0 0.0 6.1 0.0 0.0 0.2 3.8 1.3 0.0 9.8 4.1 4.3 2.4 12.3 0.0 0.0 6.3 4.2 0.7 4.3 7.7 16.7 0.0 0.1 0.7 4.8 3.4 0.0 7.0 0.7 4.1 2.9 43.7 1.5 0.9 20.9 5.4 13.1 1.9 2.1 7.2 7.1 34.3 15.7 0.3 0.0 7.4 23.4 2.6 1.1 1.3 0.0 0.0 4.2 2.0 0.7 0.9 4.7 7.4 1.0 3.9 0.2 0.5 30.4 IRAK3 IRAK-M ENSG00000090376 "Interleukin 1 receptor associated kinase 3" Q9Y616 12 66189195-66254622 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Asthma "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 78.1" "Cell type enhanced" "Detected in many" "Adipocytes: 83.3;Kupffer cells: 123.0;Macrophages: 126.3;Microglial cells: 114.3;monocytes: 96.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "basophil: 12.7;classical monocyte: 23.4;intermediate monocyte: 24.2;myeloid DC: 11.5;neutrophil: 12.9;non-classical monocyte: 42.0" "Group enriched" "Detected in many" 12 "dendritic cells: 11.5;granulocytes: 12.9;monocytes: 42.0" "Cell line enhanced" "Detected in many" "ASC diff: 25.9;ASC TERT1: 21.1;HEL: 22.9;HL-60: 30.8;NB-4: 25.1;THP-1: 37.3;U-937: 26.8" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" HPA043097 Approved Approved Vesicles "Intracellular and membrane" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 32: U-937 - Innate immune response" "Cluster 41: Macrophages - Immune response" Vesicles "HPA043097: AB_10795612" "unprognostic (7.12e-2)" "unprognostic (1.06e-1)" "unprognostic (2.90e-1)" "unprognostic (1.28e-1)" "unprognostic (1.90e-1)" "unprognostic (7.56e-3)" "unprognostic (1.49e-1)" "unprognostic (2.46e-1)" "unprognostic (7.82e-2)" "unprognostic (1.33e-1)" "unprognostic (2.95e-2)" "unprognostic (8.52e-2)" "prognostic unfavorable (6.23e-4)" "unprognostic (5.58e-2)" "unprognostic (4.64e-2)" "unprognostic (3.41e-2)" "unprognostic (3.23e-2)" 18.7 3.8 3.7 12.4 4.1 78.1 11.6 4.1 7.5 9.3 5.4 4.6 1.3 4.0 3.0 3.8 8.0 6.9 7.9 3.2 4.7 3.5 2.8 19.0 4.1 5.6 5.7 3.2 2.5 0.9 8.9 6.8 6.5 5.3 2.8 0.4 6.2 5.6 2.6 3.4 5.6 5.4 5.0 27.5 6.9 1.8 5.6 2.7 5.0 4.6 3.9 8.4 6.6 5.1 0.0 0.0 0.4 0.0 25.9 21.1 0.0 2.9 0.0 1.5 2.3 0.0 2.2 0.0 1.4 5.3 0.0 0.0 3.2 0.0 1.3 0.0 0.0 22.9 1.4 0.0 13.4 30.8 4.0 13.5 0.1 1.2 0.0 0.0 7.6 0.0 0.0 0.0 1.0 0.0 0.0 25.1 1.3 0.0 0.0 0.0 6.4 0.0 0.1 3.3 0.1 0.0 11.6 0.0 1.2 0.1 0.1 37.3 8.2 0.0 0.0 0.0 0.0 0.9 0.2 2.2 0.0 26.8 0.0 12.7 23.4 4.3 0.0 24.2 0.0 0.1 0.0 0.0 11.5 0.7 0.0 0.0 12.9 1.8 42.0 0.1 0.6 7.3 3.7 4.1 4.1 7.5 3.2 4.7 5.6 5.7 6.5 5.0 5.6 5.1 83.3 9.6 19.4 1.3 2.3 1.5 4.8 27.5 6.2 0.3 2.5 1.8 2.8 0.0 46.9 3.7 0.0 0.2 14.8 0.5 0.0 0.6 6.4 0.5 7.5 38.5 0.0 9.7 0.4 1.2 0.4 22.3 18.3 0.5 27.3 0.5 36.4 1.2 9.4 0.0 5.6 1.1 36.7 123.0 12.1 5.3 7.2 126.3 5.4 114.3 96.9 0.2 3.1 2.0 0.6 4.9 0.1 11.3 9.1 1.6 0.0 0.2 35.1 0.1 0.0 18.1 10.2 0.8 1.8 1.2 1.3 0.3 3.5 12.5 0.7 2.5 IRAK4 NY-REN-64 ENSG00000198001 "Interleukin 1 receptor associated kinase 4" Q9NWZ3 12 43758944-43789543 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Immunity, Innate immunity" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "U-937: 56.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB016685, CAB022077" Uncertain Approved Nucleoli,Microtubules,Cytosol NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 32: U-937 - Innate immune response" "Cluster 63: NK-cells & T-cells - Immune response" Microtubules "Nucleoli, Cytosol" "CAB016685: AB_1618505, CAB022077: " "unprognostic (2.76e-2)" "unprognostic (5.63e-2)" "unprognostic (1.47e-2)" "prognostic favorable (3.46e-5)" "unprognostic (6.15e-2)" "unprognostic (3.50e-3)" "unprognostic (1.44e-2)" "unprognostic (8.49e-2)" "unprognostic (6.44e-3)" "unprognostic (7.50e-2)" "unprognostic (4.00e-3)" "unprognostic (6.29e-2)" "unprognostic (4.52e-2)" "unprognostic (2.95e-1)" "unprognostic (2.31e-1)" "unprognostic (1.84e-1)" "prognostic favorable (4.42e-5)" 8.6 6.5 4.0 13.6 4.6 10.0 8.9 4.5 5.1 7.9 5.1 7.9 9.1 6.8 7.0 10.5 7.0 8.8 5.4 3.9 4.6 8.0 9.2 8.5 17.5 5.5 4.7 5.6 15.1 6.9 6.2 8.3 5.4 7.5 8.4 12.3 8.4 7.0 3.0 13.3 11.9 7.2 4.8 18.6 10.5 5.8 4.9 18.5 10.9 3.2 16.3 7.8 7.9 5.3 9.3 6.8 4.7 6.2 16.5 27.6 6.7 12.9 9.1 10.0 9.1 5.8 8.7 15.8 12.4 10.7 6.6 7.5 5.3 8.3 14.2 22.8 4.9 15.2 5.2 3.7 9.4 21.2 17.7 14.7 12.7 12.7 7.4 17.4 15.0 15.1 14.4 11.6 27.8 5.1 18.6 11.7 1.7 0.0 7.9 12.2 5.8 8.4 7.8 8.8 3.4 3.3 6.3 7.9 6.2 6.4 9.9 18.5 13.4 12.2 2.3 15.1 9.0 14.0 19.4 13.7 12.7 56.2 6.9 20.8 4.0 8.7 6.1 4.6 6.3 3.3 4.9 5.3 3.7 4.4 4.4 4.8 7.9 7.9 5.9 5.1 6.7 4.6 4.0 4.6 4.5 5.1 3.9 4.6 5.5 4.7 5.4 4.8 4.9 5.3 24.1 19.2 15.6 5.2 36.5 10.8 11.3 10.7 17.1 5.8 15.2 11.2 4.5 17.2 11.3 33.1 20.9 14.9 52.1 15.7 21.5 12.7 18.4 14.1 12.4 17.3 3.6 12.0 2.9 17.8 8.4 13.7 33.6 15.2 22.1 10.7 16.1 8.7 16.9 8.4 3.4 11.9 14.2 24.7 20.2 23.2 12.5 25.1 10.6 20.6 28.2 9.9 60.8 2.5 14.7 13.3 7.2 11.3 33.2 8.9 18.6 13.8 9.5 27.2 6.6 9.5 11.0 28.2 12.5 17.2 11.8 27.9 41.1 15.0 9.2 13.5 ITCH AIP4 ENSG00000078747 "Itchy E3 ubiquitin protein ligase" Q96J02 20 34363241-34540748 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Antiviral defense, Apoptosis, Host-virus interaction, Immunity, Innate immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 139.7;Oligodendrocytes: 260.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021126, HPA049032, CAB072824, CAB072825" Supported Enhanced Nucleoplasm,Vesicles No No "Cluster 1: Neutrophils - Mixed function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm Vesicles "CAB072824: , CAB072825: , HPA021126: AB_1851941, HPA049032: AB_2680607" "unprognostic (2.51e-1)" "unprognostic (6.95e-2)" "unprognostic (1.25e-3)" "unprognostic (3.22e-2)" "unprognostic (1.77e-1)" "unprognostic (1.13e-1)" "unprognostic (2.78e-1)" "unprognostic (9.29e-3)" "unprognostic (1.94e-1)" "unprognostic (3.89e-3)" "unprognostic (1.28e-3)" "unprognostic (1.42e-1)" "unprognostic (1.84e-2)" "unprognostic (1.30e-1)" "unprognostic (2.24e-1)" "unprognostic (3.23e-2)" "unprognostic (2.21e-1)" 19.5 16.2 13.7 18.1 27.1 27.3 20.0 19.6 17.7 24.5 17.7 21.6 20.2 19.4 16.6 42.8 15.7 17.0 20.2 14.7 15.9 23.3 55.6 18.7 21.4 19.8 20.0 18.8 16.5 23.1 7.8 25.6 21.0 19.6 23.5 25.6 18.7 19.9 17.2 14.0 20.9 21.5 15.9 20.4 20.9 38.5 20.2 23.2 26.3 21.7 25.7 30.6 14.8 45.7 55.5 34.6 35.2 25.9 38.3 57.4 42.7 43.5 52.0 56.2 54.0 101.5 83.8 26.7 42.1 55.6 73.9 66.2 54.9 92.3 66.2 20.8 17.9 78.3 28.2 59.3 43.9 32.6 34.4 31.7 46.2 44.4 72.2 49.8 41.7 40.6 45.5 45.7 46.2 26.5 49.2 18.8 16.9 35.6 44.2 40.9 76.3 63.6 34.7 91.2 21.4 16.4 82.0 32.7 51.0 33.9 38.3 31.1 39.5 61.5 36.0 42.8 33.3 36.2 40.5 40.0 41.0 21.6 38.0 4.6 6.7 7.0 12.0 7.0 12.5 9.2 4.2 6.1 4.9 7.8 3.7 5.7 20.2 7.6 4.9 14.3 5.8 4.3 13.7 27.1 19.6 17.7 14.7 15.9 19.8 20.0 21.0 15.9 20.2 45.7 26.1 12.8 21.8 56.5 33.1 15.0 23.9 11.7 25.6 19.5 15.1 8.5 25.0 12.8 25.6 31.3 25.0 17.5 46.1 28.8 5.9 12.8 59.0 26.5 34.6 20.7 12.0 26.5 85.0 16.3 21.2 24.2 33.1 36.1 19.0 17.9 18.2 53.0 15.8 15.2 72.3 16.9 10.2 24.3 26.7 139.7 22.4 31.4 26.6 68.4 30.0 38.2 43.3 79.4 260.0 22.6 23.7 15.4 50.3 25.8 21.1 26.8 23.5 26.0 13.1 21.4 22.0 40.6 25.5 30.4 16.2 46.9 30.8 12.3 11.9 40.6 KALRN "ARHGEF24, DUET, duo, HAPIP, Hs.8004, Kalirin, TRAD" ENSG00000160145 "Kalirin RhoGEF kinase" O60229 3 124080023-124726325 "Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Guanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 31.3" "Group enriched" "Detected in many" 5 "Excitatory neurons: 1434.2;Inhibitory neurons: 480.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in single" "T-reg: 1.6" "Lineage enriched" "Detected in single" 5 "T-cells: 1.6" "Cell line enhanced" "Detected in many" "CACO-2: 57.4;HEL: 35.3;OE19: 20.1;SH-SY5Y: 15.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA011913, CAB026456" Approved Approved Nucleoplasm,Cytosol NA NA 83000 "Cluster 35: T-regs - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 39: CACO-2 - Unknown function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoplasm, Cytosol" "CAB026456: , HPA011913: AB_1850494" "unprognostic (2.54e-2)" "unprognostic (3.43e-1)" "unprognostic (2.08e-1)" "unprognostic (3.12e-4)" "unprognostic (2.54e-1)" "unprognostic (1.74e-1)" "unprognostic (1.52e-1)" "unprognostic (1.53e-1)" "unprognostic (3.41e-2)" "unprognostic (8.58e-2)" "unprognostic (1.65e-1)" "unprognostic (1.04e-1)" "unprognostic (2.26e-3)" "unprognostic (5.58e-2)" "unprognostic (2.67e-1)" "unprognostic (3.70e-2)" "unprognostic (2.81e-3)" 9.4 6.3 15.0 2.2 23.4 0.3 6.7 0.0 31.3 9.1 4.9 2.0 2.5 7.7 1.9 9.5 4.6 2.9 12.8 21.3 3.4 3.8 5.8 4.4 0.9 0.0 6.6 3.1 8.8 3.5 4.1 4.2 0.0 2.8 1.8 4.5 2.8 4.9 27.2 2.0 2.0 6.2 0.0 8.5 12.1 2.6 10.7 0.5 5.1 19.3 1.6 2.6 6.0 20.9 0.7 1.1 6.2 1.3 0.9 0.2 8.1 2.5 1.5 2.4 1.1 57.4 4.5 0.2 0.8 6.4 3.9 0.4 1.4 0.0 2.0 0.0 0.7 35.3 0.4 8.9 0.1 0.0 0.0 0.4 0.0 0.5 0.1 2.6 2.9 0.1 8.3 0.2 0.7 4.2 0.0 0.0 3.5 20.1 5.4 1.8 2.8 0.0 0.2 0.5 2.1 15.9 0.7 0.5 0.5 6.0 1.2 0.1 14.4 7.0 2.8 1.0 1.1 0.0 0.6 0.0 0.8 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.0 0.7 0.2 0.2 0.0 0.0 0.0 1.6 0.4 15.0 23.4 0.0 31.3 21.3 3.4 0.0 6.6 0.0 0.0 10.7 20.9 56.2 3.2 3.9 191.3 0.6 1.7 1.5 0.3 0.6 61.2 6.1 7.1 32.1 18.6 0.5 16.5 6.2 8.0 2.5 40.5 1.9 5.0 57.0 15.0 18.8 23.2 9.6 5.3 1434.2 8.4 1.7 5.9 29.0 7.4 3.8 4.4 45.3 21.7 1.0 0.0 480.8 16.4 0.0 1.6 1.1 64.0 3.7 5.3 3.6 48.7 0.0 4.7 8.2 162.3 63.1 4.4 21.0 33.1 0.3 2.6 34.8 3.6 8.4 2.7 19.7 8.8 21.8 5.2 2.6 4.9 1.1 14.2 1.0 17.5 12.3 1.6 KANSL3 "FLJ10081, KIAA1310, NSL3, Rcd1" ENSG00000114982 "KAT8 regulatory NSL complex subunit 3" Q9P2N6 2 96593170-96642787 "Metabolic proteins, Predicted intracellular proteins" "Chromatin regulator" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035017, HPA035018" Approved Supported Nucleoplasm,Vesicles NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 52: Non-specific - Ribosome" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm Vesicles "HPA035017: AB_2674414, HPA035018: AB_10601763" "unprognostic (2.19e-1)" "unprognostic (6.94e-2)" "unprognostic (5.62e-2)" "unprognostic (8.72e-3)" "unprognostic (3.28e-1)" "unprognostic (4.35e-3)" "prognostic unfavorable (5.34e-4)" "unprognostic (6.34e-2)" "unprognostic (1.41e-1)" "unprognostic (2.02e-1)" "unprognostic (3.01e-2)" "unprognostic (2.99e-2)" "unprognostic (2.04e-3)" "unprognostic (3.28e-1)" "unprognostic (1.92e-1)" "unprognostic (8.30e-3)" "unprognostic (4.99e-3)" 11.8 9.9 1.9 8.6 2.4 14.9 12.3 1.6 3.1 13.7 8.1 11.8 7.2 15.0 7.7 8.9 12.5 6.9 10.7 2.9 2.6 8.8 6.4 9.9 8.2 2.1 2.9 15.1 9.8 15.1 8.8 9.0 2.3 11.2 6.9 6.3 12.5 14.7 33.9 10.8 12.0 10.6 3.3 10.1 9.8 12.8 3.3 13.1 12.9 21.1 8.9 13.0 10.8 2.3 13.1 7.9 26.0 19.4 10.6 6.4 11.4 9.7 15.2 20.1 21.4 15.1 7.8 18.1 14.6 16.2 14.7 8.2 18.8 9.4 17.5 12.8 14.8 26.0 8.1 16.2 15.0 17.4 9.0 15.0 5.8 12.8 11.4 12.0 11.0 21.0 18.6 12.8 12.8 6.9 32.3 13.5 12.5 6.7 12.8 26.2 16.5 10.6 12.4 12.7 26.8 16.9 12.3 11.8 11.8 14.7 11.4 5.5 15.9 13.5 11.8 9.8 8.9 10.1 6.7 15.7 7.0 19.9 12.2 2.4 1.3 0.5 2.8 1.5 2.1 1.6 1.7 2.9 0.7 1.5 1.2 2.3 0.2 3.1 1.3 0.7 1.1 1.7 1.9 2.4 1.6 3.1 2.9 2.6 2.1 2.9 2.3 3.3 3.3 2.3 11.6 44.8 30.8 29.0 10.5 4.6 9.9 8.1 9.1 15.0 14.8 12.2 23.8 10.0 18.8 11.0 43.8 8.1 10.0 15.0 3.9 10.5 13.4 13.0 13.7 12.1 13.1 6.7 35.6 9.6 4.3 12.7 17.3 13.5 18.3 33.1 15.7 12.7 8.1 15.2 36.2 18.4 10.2 12.5 5.6 28.6 9.9 11.2 7.2 16.9 13.7 10.2 9.2 29.7 37.3 13.2 7.9 12.8 10.6 10.3 10.7 5.8 13.1 29.5 13.1 16.0 13.6 23.3 9.7 11.3 6.5 11.1 14.2 18.3 15.6 10.1 KAT2A "GCN5, GCN5L2, PCAF-b" ENSG00000108773 "Lysine acetyltransferase 2A" Q92830 17 42113111-42121367 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction, Transcription, Transcription regulation" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 84.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA048958 Uncertain NA NA "Cluster 30: Non-specific - Translation" "Cluster 72: Non-specific - Transcription" "Cluster 21: OE19 - Mitochondria" "Cluster 52: Non-specific - Transcription" "HPA048958: AB_2680571" "unprognostic (1.71e-1)" "unprognostic (9.08e-2)" "unprognostic (1.66e-1)" "unprognostic (2.31e-1)" "unprognostic (3.41e-1)" "unprognostic (9.07e-2)" "unprognostic (1.91e-3)" "unprognostic (3.87e-2)" "unprognostic (2.53e-1)" "unprognostic (1.09e-1)" "prognostic favorable (3.57e-4)" "unprognostic (2.78e-2)" "prognostic unfavorable (1.41e-8)" "unprognostic (3.97e-2)" "unprognostic (2.90e-1)" "unprognostic (1.89e-1)" "unprognostic (2.29e-3)" 14.1 20.8 11.3 6.5 11.9 4.2 13.2 7.7 18.9 20.3 3.1 15.4 6.7 17.2 1.7 14.7 21.0 3.1 10.1 10.8 12.7 13.1 15.7 9.7 5.3 10.8 10.4 28.4 16.9 5.8 14.4 4.6 10.0 16.9 4.0 1.0 10.0 4.3 11.8 15.9 13.5 3.4 5.3 17.4 13.0 10.8 14.0 4.7 14.6 2.1 4.6 15.5 16.4 12.4 24.7 46.6 6.8 25.3 9.3 7.6 29.7 15.7 8.3 34.0 16.7 31.9 19.5 48.1 38.6 12.1 25.6 36.0 27.9 25.0 12.1 27.0 58.0 12.0 29.8 28.8 9.7 32.3 30.8 9.0 20.8 19.1 11.9 9.2 13.8 11.9 30.7 8.9 9.1 26.4 77.7 23.5 14.5 60.9 0.0 18.3 13.3 31.9 9.2 24.4 32.4 14.2 16.8 36.2 13.2 5.1 26.9 15.3 10.7 17.1 17.4 25.1 28.2 23.8 24.5 26.9 12.5 27.5 9.7 0.0 0.1 0.0 0.2 0.0 0.4 0.5 0.5 0.6 0.4 0.3 0.6 0.1 0.0 0.1 0.0 0.1 0.0 0.2 11.3 11.9 7.7 18.9 10.8 12.7 10.8 10.4 10.0 5.3 14.0 12.4 21.5 12.8 11.5 84.5 19.0 12.2 12.6 6.8 26.2 16.5 18.9 22.7 7.1 18.6 6.6 18.4 10.4 25.1 10.7 7.9 3.9 9.2 1.3 5.9 11.3 18.4 15.7 6.7 39.6 8.0 20.5 12.1 17.3 8.2 11.4 25.8 22.5 20.2 12.1 10.1 41.0 10.1 6.1 10.9 6.8 3.7 32.6 9.8 7.2 32.8 5.2 3.7 5.2 41.7 28.3 6.7 7.3 29.0 7.2 10.9 4.0 4.1 5.4 7.8 13.1 15.1 10.8 5.2 18.2 18.7 13.9 11.2 7.8 26.4 20.2 9.1 KAT2B "GCN5, GCN5L, P/CAF, PCAF" ENSG00000114166 "Lysine acetyltransferase 2B" Q92831 3 20040446-20154404 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, Cell cycle, Host-virus interaction, Transcription, Transcription regulation" "Activator, Acyltransferase, Transferase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 165.2;Oligodendrocyte precursor cells: 418.2;Oligodendrocytes: 175.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002470, CAB004526, HPA055839, HPA073897" Supported Enhanced Nucleoplasm,Cytosol NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 68: Oligodendrocytes - Mixed function" Nucleoplasm Cytosol "CAB004526: AB_2128417, HPA002470: , HPA055839: AB_2682938, HPA073897: " "unprognostic (2.91e-2)" "unprognostic (6.85e-3)" "unprognostic (9.05e-2)" "unprognostic (2.25e-1)" "unprognostic (2.66e-2)" "unprognostic (3.01e-3)" "unprognostic (2.44e-1)" "unprognostic (3.83e-3)" "unprognostic (2.44e-2)" "unprognostic (1.03e-1)" "unprognostic (5.23e-3)" "unprognostic (7.13e-2)" "unprognostic (7.03e-2)" "unprognostic (2.26e-2)" "unprognostic (1.59e-1)" "unprognostic (5.16e-2)" "unprognostic (4.63e-2)" 17.9 9.9 38.7 15.4 46.5 48.0 10.3 39.1 40.3 14.9 33.8 13.8 17.7 12.3 8.1 27.4 11.7 12.6 35.9 34.4 42.2 16.6 39.3 16.2 22.4 41.7 44.9 27.7 18.7 51.0 10.2 13.7 43.0 14.5 12.5 33.9 37.6 13.0 60.2 14.3 21.5 13.6 37.1 19.8 13.9 2.7 42.2 23.6 14.4 56.1 20.1 11.9 15.1 45.1 2.7 6.9 3.8 6.2 15.1 14.2 8.8 8.8 13.0 9.1 13.3 2.1 4.5 24.0 3.6 16.7 11.5 2.0 9.4 2.8 7.6 21.8 9.0 21.0 10.7 0.7 7.1 3.2 26.2 6.1 5.0 7.9 5.1 16.0 8.8 5.8 13.7 32.9 13.0 3.3 7.0 6.4 1.6 6.7 6.8 9.1 7.1 5.1 12.4 14.2 1.9 4.1 4.9 7.9 30.5 5.9 8.2 14.2 8.5 15.3 6.1 5.8 10.1 12.3 27.6 5.7 13.9 13.8 33.0 0.6 0.4 1.3 1.5 0.7 1.5 0.4 1.3 1.1 0.4 0.8 0.4 0.8 2.4 0.5 0.5 1.2 2.2 0.3 38.7 46.5 39.1 40.3 34.4 42.2 41.7 44.9 43.0 37.1 42.2 45.1 15.5 32.1 20.8 165.2 11.9 8.5 11.3 2.2 3.4 14.6 5.5 5.0 64.1 4.3 10.4 5.5 4.2 7.3 19.5 16.6 11.7 3.8 3.8 6.4 5.7 14.6 11.5 52.2 22.4 4.4 1.1 11.7 3.6 13.1 10.8 12.3 20.7 33.6 7.7 15.2 32.1 7.3 4.1 22.8 23.3 1.8 6.5 16.0 17.8 52.5 11.1 14.8 14.4 418.2 175.4 3.3 2.4 5.3 19.9 7.1 24.7 6.2 12.7 11.9 6.6 25.2 9.0 0.8 1.4 10.0 12.9 9.9 23.5 2.9 3.8 8.0 KAT5 "cPLA2, ESA1, HTATIP, HTATIP1, PLIP, TIP60, ZC2HC5" ENSG00000172977 "Lysine acetyltransferase 5" Q92993 11 65711996-65719604 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transcription factors" "Growth regulation, Host-virus interaction, Transcription, Transcription regulation" "Activator, Acyltransferase, Chromatin regulator, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016953, HPA074328" Approved Supported Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Nucleoplasm "Vesicles, Cytosol" "HPA016953: AB_1851277, HPA074328: " "unprognostic (2.20e-1)" "unprognostic (3.58e-1)" "unprognostic (3.59e-2)" "unprognostic (2.74e-1)" "unprognostic (9.61e-2)" "unprognostic (7.16e-2)" "unprognostic (1.29e-3)" "unprognostic (1.20e-1)" "unprognostic (2.01e-1)" "unprognostic (2.74e-1)" "unprognostic (2.13e-1)" "unprognostic (2.54e-1)" "prognostic favorable (1.10e-13)" "unprognostic (1.37e-1)" "unprognostic (2.55e-1)" "unprognostic (1.85e-1)" "unprognostic (8.54e-2)" 31.6 30.0 38.7 23.8 41.0 52.9 32.1 41.7 48.8 39.5 38.6 43.6 21.6 45.1 33.7 34.9 44.9 20.5 32.4 37.9 38.9 32.9 26.3 29.5 28.0 40.0 39.5 39.2 32.7 45.6 33.7 29.9 41.2 33.1 27.0 31.0 29.6 36.3 42.8 47.6 32.2 35.2 40.0 34.3 35.9 45.2 39.9 39.3 38.2 34.6 30.2 39.5 34.8 43.8 37.2 44.1 40.1 29.6 31.3 32.7 41.1 26.7 43.6 44.0 38.0 32.6 42.2 34.3 36.2 47.4 47.5 30.8 50.8 45.1 26.4 44.4 32.5 50.6 36.3 38.9 44.6 55.7 56.4 35.2 49.7 28.9 59.0 33.7 28.1 39.1 52.5 51.1 42.0 68.2 45.7 62.3 33.9 26.8 28.4 38.2 26.5 63.3 40.6 56.2 37.1 38.9 25.4 46.5 51.2 20.8 45.9 34.2 36.3 33.9 30.4 27.6 28.0 38.7 43.7 50.4 29.7 27.0 29.3 42.7 33.6 58.8 33.4 32.0 29.6 28.2 28.8 34.2 34.1 30.4 36.5 29.8 34.8 35.8 34.6 20.9 31.0 36.4 38.7 41.0 41.7 48.8 37.9 38.9 40.0 39.5 41.2 40.0 39.9 43.8 17.6 12.8 17.5 10.7 26.0 21.2 44.2 60.2 17.6 44.9 17.3 15.0 1.0 25.8 33.8 29.5 31.3 51.3 25.6 27.1 35.2 42.2 11.1 20.2 14.2 18.7 30.4 12.4 7.5 51.5 42.6 21.1 20.4 19.8 33.7 27.0 18.2 10.9 36.3 38.7 8.7 25.1 42.7 17.6 15.2 11.1 28.0 20.4 42.7 3.7 38.8 40.3 33.0 7.1 13.8 39.4 30.6 38.7 10.4 24.2 23.3 32.6 30.0 44.8 46.0 27.6 27.0 61.1 27.8 14.6 21.3 102.5 21.6 29.2 26.2 31.0 KAT6A "MOZ, MYST3, RUNXBP2, ZC2HC6A, ZNF220" ENSG00000083168 "Lysine acetyltransferase 6A" Q92794 8 41929479-42051994 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Acyltransferase, Chromatin regulator, Repressor, Transferase" "Cancer-related genes, Mental retardation, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017023, HPA063266, HPA065052" Supported Supported "Nucleoli,Nuclear speckles,Cytosol" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 34: Non-specific - Transcription" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" "Nuclear speckles" "Nucleoli, Cytosol" "CAB017023: , HPA063266: AB_2684973, HPA065052: AB_2685414" "unprognostic (3.51e-2)" "unprognostic (1.14e-1)" "unprognostic (2.04e-1)" "unprognostic (3.23e-2)" "unprognostic (2.28e-1)" "unprognostic (9.27e-3)" "unprognostic (3.61e-1)" "unprognostic (2.29e-1)" "unprognostic (2.95e-1)" "unprognostic (2.45e-2)" "unprognostic (1.50e-1)" "unprognostic (4.45e-2)" "unprognostic (4.20e-3)" "unprognostic (1.18e-1)" "unprognostic (2.24e-1)" "unprognostic (8.58e-2)" "unprognostic (2.95e-2)" 14.4 7.1 8.6 15.4 12.7 38.2 12.3 20.1 10.5 13.7 9.7 10.2 9.6 15.6 8.6 13.4 12.0 11.2 9.1 9.1 12.8 9.1 10.0 16.7 16.8 12.7 12.4 21.5 11.7 18.0 6.7 14.9 12.9 11.0 10.6 18.1 9.6 9.7 13.1 16.6 12.1 13.5 8.2 15.7 11.3 11.4 10.1 27.0 14.2 16.0 17.2 12.0 10.7 16.7 19.6 23.2 34.8 21.8 17.8 20.3 9.8 15.4 20.6 17.9 14.2 16.3 11.5 33.4 13.4 19.0 19.5 17.3 27.3 18.6 23.2 16.1 14.4 60.4 14.2 10.3 14.8 27.3 23.6 17.1 19.1 20.4 24.8 14.5 18.8 29.7 36.6 24.2 16.0 10.4 59.9 9.4 12.8 20.4 8.1 37.7 39.1 9.9 11.0 27.1 17.6 16.7 15.8 12.4 13.8 15.8 26.3 12.9 25.5 21.6 15.3 21.1 15.5 16.8 22.1 33.8 12.6 14.1 17.3 2.5 0.8 1.8 1.6 0.9 1.6 1.4 1.6 2.1 0.6 1.6 1.9 1.8 5.1 1.9 0.9 1.1 1.9 1.2 8.6 12.7 20.1 10.5 9.1 12.8 12.7 12.4 12.9 8.2 10.1 16.7 87.5 35.3 34.9 64.0 54.0 50.3 24.2 15.5 18.2 54.8 31.7 25.5 23.7 18.6 25.3 12.9 54.2 14.4 61.5 23.2 3.9 14.2 2.6 30.3 47.5 56.7 24.7 31.2 62.8 11.8 17.0 32.4 21.4 44.8 35.4 31.9 43.5 25.3 17.0 58.9 76.6 24.9 10.2 44.2 34.5 4.8 28.3 43.7 23.2 120.9 30.3 27.9 61.8 93.5 129.2 15.7 20.2 23.0 38.7 30.7 22.9 10.6 22.8 44.9 19.7 49.3 34.6 37.8 37.0 23.0 61.2 21.1 61.4 19.7 19.3 27.2 KAT6B "Morf, MOZ2, MYST4, qkf, querkopf, ZC2HC6B" ENSG00000156650 "Lysine acetyltransferase 6B" Q8WYB5 10 74824927-75032624 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Acyltransferase, Chromatin regulator, Repressor, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "PC-3: 25.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006104 Supported Approved "Nucleoplasm,Nuclear bodies" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 24: Non-specific - Transcription regulation" "Nucleoplasm, Nuclear bodies" "HPA006104: AB_1079445" "unprognostic (4.17e-1)" "unprognostic (1.98e-1)" "unprognostic (1.82e-1)" "unprognostic (2.32e-2)" "unprognostic (7.83e-2)" "unprognostic (2.85e-2)" "unprognostic (3.56e-1)" "unprognostic (2.62e-1)" "unprognostic (2.54e-1)" "unprognostic (1.09e-1)" "unprognostic (9.47e-2)" "unprognostic (8.78e-2)" "prognostic favorable (4.82e-4)" "unprognostic (2.52e-1)" "unprognostic (3.70e-1)" "unprognostic (2.59e-2)" "unprognostic (3.15e-1)" 7.6 6.3 5.0 3.1 5.6 8.8 7.3 5.6 5.3 10.5 2.0 9.6 3.2 9.2 5.2 6.9 8.3 3.8 7.5 5.7 4.0 4.3 4.6 6.5 4.4 3.1 3.5 12.2 8.6 10.5 7.4 4.4 3.0 6.5 4.1 6.4 7.3 4.3 11.8 8.0 8.1 6.0 3.0 5.4 9.3 7.8 5.6 9.8 7.3 6.0 4.1 9.1 8.9 4.9 4.7 4.4 8.0 6.9 6.2 9.2 4.1 4.1 7.5 3.4 3.6 3.4 5.3 9.8 2.1 7.1 3.5 3.8 4.2 3.3 5.6 4.2 6.8 3.6 3.9 4.5 4.5 8.6 2.4 5.9 5.3 4.5 6.9 10.5 3.8 7.7 3.9 9.0 4.2 4.7 8.2 4.3 5.0 4.9 25.7 12.7 4.3 2.4 2.3 2.3 4.2 6.9 4.1 7.4 3.7 2.8 4.5 3.2 4.7 4.6 5.5 3.1 3.8 6.4 8.1 6.4 5.0 8.9 1.3 1.7 1.3 1.6 2.3 1.0 2.6 2.2 1.9 2.1 1.1 2.8 2.9 2.6 1.8 4.4 1.1 1.7 1.7 1.0 5.0 5.6 5.6 5.3 5.7 4.0 3.1 3.5 3.0 3.0 5.6 4.9 34.5 44.8 53.7 90.1 48.1 19.9 20.8 16.3 74.6 52.8 36.7 27.3 53.9 12.8 29.3 9.2 68.8 10.4 51.8 22.5 9.8 12.7 6.2 41.1 72.7 24.9 23.8 32.0 130.2 18.0 10.6 44.4 57.6 50.8 41.7 68.0 18.9 16.0 11.0 43.7 131.2 21.7 12.2 12.3 15.0 8.3 42.3 24.1 14.2 41.2 13.6 45.5 42.2 101.0 92.1 10.5 19.4 40.3 62.5 21.0 17.8 10.2 28.6 52.5 26.3 55.3 44.1 33.1 32.2 46.6 17.5 22.7 59.7 27.1 17.5 23.5 KAT7 "HBO1, HBOA, MYST2, ZC2HC7" ENSG00000136504 "Lysine acetyltransferase 7" O95251 17 49788648-49835026 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transcription factors" "DNA damage, DNA repair, DNA replication, Transcription, Transcription regulation" "Acyltransferase, Chromatin regulator, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA044470, HPA071116" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 42: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 5: NTERA-2 - Transcription" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm Cytosol "HPA044470: AB_10965785, HPA071116: " "unprognostic (1.30e-1)" "unprognostic (3.15e-2)" "unprognostic (6.20e-3)" "unprognostic (2.20e-2)" "unprognostic (7.99e-2)" "unprognostic (1.53e-1)" "unprognostic (1.35e-2)" "unprognostic (1.72e-2)" "unprognostic (1.36e-1)" "unprognostic (6.26e-2)" "unprognostic (1.44e-2)" "unprognostic (2.52e-1)" "unprognostic (1.33e-3)" "unprognostic (2.75e-1)" "unprognostic (5.03e-2)" "unprognostic (6.23e-2)" "unprognostic (7.68e-2)" 17.6 14.2 16.1 8.1 16.9 40.9 16.6 24.2 21.5 20.1 15.1 20.9 7.2 22.6 12.2 20.4 20.3 6.6 22.8 16.5 14.8 17.7 11.7 14.5 10.4 13.6 12.3 20.9 12.4 23.5 17.1 10.0 15.5 17.5 10.0 19.2 17.8 14.0 37.7 25.5 16.0 12.4 10.3 15.9 16.0 38.6 14.9 17.4 21.1 20.1 13.5 22.5 19.0 18.7 17.1 22.6 22.5 17.3 10.1 14.3 27.2 11.2 16.5 24.7 18.7 35.9 11.5 17.8 21.8 13.7 24.7 16.7 23.0 12.8 32.5 18.6 20.3 20.7 14.8 17.8 15.0 21.6 17.2 13.3 16.6 21.1 25.3 14.4 22.7 16.0 23.6 18.9 27.4 28.8 26.4 23.2 79.0 38.4 20.2 20.6 34.7 18.2 12.8 17.6 25.7 15.7 7.6 9.2 14.9 40.5 38.6 22.9 8.8 24.5 13.3 16.0 19.4 21.4 32.7 23.3 17.3 13.6 23.3 17.1 6.8 9.5 8.3 5.4 10.6 5.8 7.8 8.5 7.0 6.1 9.3 8.5 10.1 11.7 7.1 4.3 8.5 7.9 16.1 16.9 24.2 21.5 16.5 14.8 13.6 12.3 15.5 10.3 14.9 18.7 16.0 25.6 21.3 9.4 23.6 16.8 11.7 10.1 25.0 32.6 18.5 16.6 28.5 20.0 15.6 27.6 31.3 22.7 27.6 11.7 9.8 11.9 23.1 22.4 21.0 18.7 25.1 25.4 14.8 7.5 14.5 15.3 15.3 29.9 24.1 18.2 15.4 10.4 13.3 45.4 16.7 13.4 12.2 22.6 13.2 16.5 16.8 15.9 14.2 10.3 19.1 16.5 25.7 13.0 18.3 10.0 8.9 18.4 18.6 15.4 12.8 10.2 18.6 25.1 39.5 21.2 24.2 73.7 31.6 17.9 20.0 33.8 28.4 15.2 12.1 10.2 KAT8 "FLJ14040, hMOF, MOF, MYST1, ZC2HC8" ENSG00000103510 "Lysine acetyltransferase 8" Q9H7Z6 16 31114489-31131393 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Acyltransferase, Chromatin regulator, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 113.9;Late spermatids: 147.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "eosinophil: 29.9" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA066324 Supported Nucleoplasm NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 34: Spermatids - Unknown function" Nucleoplasm "HPA066324: AB_2685658" "unprognostic (8.58e-2)" "unprognostic (9.53e-2)" "unprognostic (7.83e-2)" "unprognostic (1.12e-2)" "unprognostic (8.59e-2)" "unprognostic (1.06e-1)" "unprognostic (3.22e-1)" "prognostic favorable (6.34e-4)" "unprognostic (3.13e-2)" "unprognostic (3.05e-1)" "unprognostic (5.50e-2)" "unprognostic (9.77e-2)" "unprognostic (7.33e-2)" "unprognostic (2.97e-1)" "unprognostic (1.29e-1)" "unprognostic (5.00e-1)" "unprognostic (1.41e-1)" 28.8 30.9 40.4 17.8 41.6 32.9 31.3 50.6 50.4 40.8 38.2 36.9 16.6 39.2 46.5 21.1 41.7 14.7 42.0 41.5 41.6 28.4 29.0 31.3 24.6 42.0 41.3 60.7 31.8 37.4 31.0 20.4 41.3 32.0 17.3 27.5 34.7 23.7 49.8 33.8 30.2 25.5 40.0 39.7 28.2 32.8 41.6 39.6 35.5 49.8 23.3 30.9 31.0 43.1 18.1 27.4 33.5 10.7 38.5 28.9 34.3 16.0 29.6 24.7 26.8 13.6 38.1 42.3 24.5 19.6 22.8 22.5 53.6 26.4 24.1 35.8 35.0 18.7 21.5 43.3 34.5 30.5 31.9 27.9 51.4 18.5 52.4 33.2 23.6 44.1 49.5 33.7 13.1 51.4 47.4 57.2 38.0 43.1 15.9 75.1 28.1 49.5 20.1 10.7 35.2 35.9 9.4 25.9 14.1 20.7 28.6 49.6 14.7 11.0 22.2 12.1 11.6 32.4 34.8 24.2 16.0 40.7 16.3 8.0 7.4 29.9 3.0 4.1 3.7 3.6 3.6 4.1 6.6 2.9 4.6 3.3 28.4 3.2 8.3 2.7 2.4 3.4 40.4 41.6 50.6 50.4 41.5 41.6 42.0 41.3 41.3 40.0 41.6 43.1 26.2 19.2 18.2 16.0 30.4 20.8 41.9 18.1 34.7 19.0 21.5 26.2 16.8 21.5 21.0 9.2 14.6 30.5 20.9 17.8 21.5 21.9 113.9 17.5 18.2 21.8 24.6 29.5 16.4 26.6 21.7 29.4 17.9 18.0 27.3 33.9 23.2 12.4 29.1 32.0 18.6 21.2 18.3 30.1 25.4 147.5 53.7 28.1 24.9 12.2 32.6 41.0 15.5 11.1 13.2 15.0 25.8 54.2 16.5 35.2 25.1 17.5 11.8 26.9 26.3 32.8 30.6 27.5 26.2 20.6 15.6 45.4 24.6 24.5 22.9 23.2 KLK1 Klk6 ENSG00000167748 "Kallikrein 1" P06870 19 50819146-50823787 "Enzymes, Metabolic proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 84 "pancreas: 9557.9;salivary gland: 5487.3" "Group enriched" "Detected in many" 7 "Exocrine glandular cells: 788.4;Intestinal goblet cells: 1317.5" "Cancer enhanced" "Detected in many" "pancreatic cancer: 50.9;renal cancer: 84.1" "Not detected" "Not detected" "Group enriched" "Detected in some" 9 "memory B-cell: 9.5;naive B-cell: 4.0" "Lineage enriched" "Detected in single" 13 "B-cells: 9.5" "Cell line enriched" "Detected in some" 4 "RPMI-8226: 43.8" HPA059690 Approved "Secreted to digestive system" NA NA 10000000 "Cluster 19: B-cells - Humoral immune response" "Cluster 25: Pancreas - Digestion" "Cluster 25: RPMI-8226 - Immune response" "Cluster 27: Mucus-secreting cells - Mucin production" "HPA059690: " "unprognostic (1.51e-3)" "unprognostic (1.23e-2)" "unprognostic (4.20e-1)" "unprognostic (1.73e-2)" "unprognostic (1.10e-1)" "unprognostic (8.72e-2)" "unprognostic (1.92e-2)" "unprognostic (7.47e-3)" "unprognostic (1.66e-1)" "unprognostic (2.49e-2)" "unprognostic (8.06e-2)" "unprognostic (2.12e-1)" "unprognostic (1.42e-2)" "unprognostic (2.55e-1)" "unprognostic (6.49e-2)" "unprognostic (2.10e-1)" "unprognostic (6.23e-2)" 1.4 2.4 0.1 4.0 0.0 0.4 1.8 0.0 0.4 1.9 0.0 68.8 9.6 2.0 0.0 1.3 0.6 0.1 3.0 0.3 0.0 89.4 0.6 0.5 0.5 0.0 0.0 4.7 9557.9 0.4 0.2 1.1 0.0 2.7 53.0 0.0 5487.3 0.1 0.2 26.3 9.7 2.8 0.0 3.3 1.4 0.1 0.0 0.2 2.9 0.2 1.5 0.2 0.9 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.7 0.4 0.2 0.3 0.5 1.6 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 1.1 0.1 0.4 0.2 0.0 0.0 0.0 0.1 1.2 0.0 0.0 0.1 0.1 0.0 0.0 9.7 0.0 0.1 0.0 43.8 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.8 0.0 0.0 0.3 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.3 0.0 9.5 0.0 0.0 0.1 4.0 0.0 0.0 0.1 0.0 0.2 0.7 0.0 0.1 0.1 0.0 0.0 0.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 18.9 19.5 1.2 2.9 1.2 0.0 1.0 1.1 0.3 0.0 2.5 0.0 0.0 0.0 0.2 62.2 45.0 3.3 0.6 0.1 1.4 0.4 117.1 0.0 0.0 788.4 0.0 7.7 1.5 0.0 8.9 8.8 0.4 0.0 0.6 0.0 0.0 1317.5 14.2 1.6 5.3 0.3 6.2 1.5 5.4 0.0 6.2 0.0 0.0 0.0 0.0 125.8 134.4 0.0 10.9 9.8 57.1 0.3 0.3 0.0 0.0 0.0 1.1 0.3 0.9 1.7 54.0 0.0 2.1 2.5 148.5 3.8 KLK2 ENSG00000167751 "Kallikrein related peptidase 2" P20151 19 50861568-50880567 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 87 "prostate: 566.2" "Cell type enriched" "Detected in some" 40 "Prostatic glandular cells: 777.2" "Cancer enriched" "Detected in some" 1666 "prostate cancer: 989.9" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "BEWO: 3.5;NB-4: 5.6" HPA000764 Supported "Secreted in male reproductive system" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 51: Non-specific - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 35: Glandular cells - Unknown function" "HPA000764: AB_1079700" "unprognostic (3.05e-2)" "unprognostic (2.40e-1)" "unprognostic (1.69e-1)" "unprognostic (8.53e-2)" "unprognostic (1.15e-1)" "unprognostic (8.97e-2)" "unprognostic (3.22e-1)" "unprognostic (6.44e-2)" "unprognostic (8.06e-2)" "unprognostic (3.61e-1)" "unprognostic (2.11e-3)" "unprognostic (7.56e-2)" "unprognostic (8.10e-2)" "unprognostic (1.68e-1)" "unprognostic (2.04e-1)" 0.7 1.1 3.2 1.2 2.3 6.4 0.5 5.2 4.3 0.2 2.2 0.4 1.5 0.6 1.1 0.5 0.3 0.2 0.3 2.6 2.2 0.4 0.8 0.5 1.0 2.2 3.1 0.4 0.0 0.8 0.0 0.2 2.9 566.2 0.3 1.7 1.9 0.4 1.0 0.8 1.0 0.1 0.6 0.7 0.5 3.0 2.4 0.0 1.9 0.0 0.2 0.2 0.0 6.3 0.9 0.6 0.3 0.7 0.0 0.4 3.5 0.2 0.1 0.1 0.1 0.3 0.4 1.0 0.1 0.0 0.3 0.9 0.1 0.0 0.1 0.9 0.6 0.0 0.7 0.0 0.0 0.1 1.7 0.2 0.1 0.1 0.2 0.2 0.0 0.6 0.7 0.9 0.2 1.0 0.6 5.6 0.5 0.9 0.0 0.4 0.0 1.6 0.0 1.1 0.5 0.5 0.1 0.7 0.6 0.1 0.5 0.2 0.4 0.6 1.0 2.6 0.9 0.8 1.8 0.4 1.0 0.6 0.7 0.4 0.6 0.5 0.3 0.3 0.2 0.3 0.2 0.3 0.1 0.6 0.2 0.4 1.7 0.4 0.2 0.5 0.1 0.2 3.2 2.3 5.2 4.3 2.6 2.2 2.2 3.1 2.9 0.6 2.4 6.3 0.0 0.0 0.6 0.0 0.2 0.3 10.2 0.0 0.0 0.0 16.1 2.8 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.8 1.5 0.0 0.0 0.0 0.0 0.2 1.1 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 5.2 0.0 4.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 777.2 0.0 0.1 0.0 0.0 0.0 0.0 1.8 19.3 7.2 0.0 0.9 0.0 0.6 1.7 0.0 12.0 LATS1 WARTS ENSG00000131023 "Large tumor suppressor kinase 1" O95835 6 149658153-149718105 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Tumor suppressor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031804 Approved NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 34: Non-specific - Transcription" "Cluster 1: K-562 - Erythropoiesis" "Cluster 59: Non-specific - Transcription" "HPA031804: AB_10601688" "unprognostic (4.02e-3)" "unprognostic (3.80e-3)" "unprognostic (1.28e-2)" "unprognostic (1.00e-1)" "unprognostic (4.40e-2)" "unprognostic (2.09e-1)" "unprognostic (6.15e-3)" "unprognostic (1.29e-2)" "unprognostic (9.67e-2)" "unprognostic (1.02e-2)" "unprognostic (1.74e-1)" "unprognostic (1.52e-1)" "unprognostic (5.62e-2)" "unprognostic (1.92e-1)" "unprognostic (8.43e-2)" "unprognostic (2.63e-1)" "unprognostic (2.65e-1)" 8.1 8.0 4.8 8.6 4.9 15.4 9.2 11.0 7.0 10.1 5.5 7.3 7.2 12.1 7.4 8.2 9.7 7.7 5.6 5.2 4.6 7.7 7.8 9.1 9.8 4.7 4.3 15.6 6.8 11.7 5.2 8.8 5.0 11.0 8.5 11.0 8.7 7.7 6.4 9.1 7.7 10.7 4.3 10.2 7.7 6.2 5.1 11.7 8.9 8.1 8.4 9.0 7.2 7.6 8.7 6.8 13.7 19.8 12.9 16.6 10.7 11.3 11.4 11.8 11.7 11.1 7.3 14.0 11.1 15.7 9.4 11.8 18.3 12.0 18.5 12.9 14.7 28.1 8.2 9.9 11.9 26.5 19.8 11.3 19.1 13.5 22.7 12.2 14.8 12.1 35.3 13.9 11.9 10.4 13.8 11.0 8.5 8.0 6.5 13.6 16.4 6.5 11.0 12.2 9.3 14.7 16.1 11.5 8.4 9.3 12.0 22.9 18.7 9.5 14.8 11.4 18.2 11.6 13.5 15.8 8.7 14.8 14.3 8.2 3.0 4.8 5.9 5.3 5.3 3.8 4.5 5.0 3.3 4.7 3.8 5.1 2.0 3.0 8.9 2.8 4.8 2.4 4.8 4.9 11.0 7.0 5.2 4.6 4.7 4.3 5.0 4.3 5.1 7.6 21.1 12.8 21.3 33.0 21.9 16.3 11.2 9.7 27.9 20.3 15.2 10.2 9.6 12.8 12.5 7.3 18.8 8.5 18.7 15.3 1.9 7.5 23.0 14.1 23.4 16.2 16.8 17.7 51.4 6.6 11.4 19.7 20.9 17.1 14.0 19.8 21.0 13.3 11.0 13.5 48.0 12.6 6.1 14.7 11.6 6.9 13.7 16.6 14.2 32.8 15.0 10.7 10.3 54.8 64.0 9.9 11.5 25.9 21.9 15.4 13.6 6.6 12.8 22.0 19.7 28.8 15.1 8.8 9.6 18.8 18.0 13.1 23.3 13.8 11.7 11.8 LATS2 ENSG00000150457 "Large tumor suppressor kinase 2" Q9NRM7 13 20973036-21061586 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 139.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039191, HPA049037" Approved Supported "Centriolar satellite,Cytosol" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 44: Endometrium - Transcription" "Centriolar satellite, Cytosol" "HPA039191: AB_2676385, HPA049037: AB_2680609" "unprognostic (2.77e-1)" "prognostic unfavorable (3.26e-4)" "unprognostic (6.22e-3)" "unprognostic (3.38e-2)" "unprognostic (2.51e-2)" "unprognostic (1.84e-2)" "unprognostic (1.88e-1)" "unprognostic (2.16e-3)" "unprognostic (4.48e-1)" "unprognostic (6.57e-3)" "unprognostic (8.03e-2)" "unprognostic (4.92e-2)" "unprognostic (7.85e-2)" "unprognostic (1.66e-2)" "unprognostic (1.25e-1)" "unprognostic (7.97e-2)" "unprognostic (1.11e-2)" 19.8 12.2 3.9 7.3 4.3 15.1 12.4 4.8 3.7 10.1 7.7 13.1 2.9 12.2 3.0 11.5 9.7 15.1 11.5 5.3 3.3 9.9 9.8 12.4 5.3 5.4 4.6 11.0 10.2 4.3 2.3 13.9 4.5 9.8 4.3 1.3 6.1 8.8 16.7 7.7 6.2 13.1 4.1 11.2 7.8 14.6 5.1 2.4 13.5 13.3 3.3 14.2 8.9 4.7 6.8 7.4 16.0 9.7 18.4 24.1 14.6 22.1 22.8 22.5 19.2 21.1 10.0 0.0 10.5 33.8 8.8 9.6 9.5 10.1 33.1 3.8 2.5 12.4 9.4 16.0 28.6 3.4 4.2 36.0 18.1 14.9 9.9 11.3 32.0 2.8 2.3 0.5 28.9 11.7 0.4 11.6 3.8 7.0 3.5 2.9 28.5 0.0 16.3 3.1 0.3 0.0 17.4 11.3 23.9 13.9 9.8 6.4 40.6 23.8 15.9 17.7 14.1 2.9 1.7 0.0 5.7 3.8 18.6 0.1 0.5 0.5 0.4 0.4 0.9 0.0 0.0 0.1 0.4 0.0 0.0 0.0 0.9 0.4 0.2 0.0 0.0 0.1 3.9 4.3 4.8 3.7 5.3 3.3 5.4 4.6 4.5 4.1 5.1 4.7 36.6 41.7 9.9 12.1 2.8 32.9 14.7 8.5 21.6 0.4 12.5 11.0 24.3 15.7 10.5 5.5 0.0 24.8 21.0 6.5 3.9 10.1 139.4 40.3 30.4 35.1 0.0 8.2 0.6 7.3 8.9 37.2 8.6 62.1 5.1 9.8 44.6 19.6 9.9 0.0 0.6 1.9 6.1 17.9 49.3 13.7 25.4 26.0 17.8 21.5 11.0 4.9 13.4 2.0 8.8 18.6 2.8 34.6 8.9 21.7 0.6 9.5 11.6 1.0 6.6 32.3 30.0 8.8 14.5 9.9 25.3 48.0 8.1 7.9 1.5 15.2 LCT ENSG00000115850 Lactase P09848 2 135787850-135837184 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Glycosidase, Hydrolase, Multifunctional enzyme" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 187 "intestine: 225.5" "Cell type enhanced" "Detected in some" "Breast glandular cells: 1.4;Breast myoepithelial cells: 3.3;Early spermatids: 1.3;Proximal enterocytes: 2.8;Undifferentiated cells: 1.1" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "JURKAT: 2.5;MOLT-4: 4.9;RPMI-8226: 9.7" "Region enriched" "Detected in some" 15 "hippocampal formation: 15.7" "Not detected" "Not detected" NA NA "Cluster 56: Intestine - Transmembrane transport" "Cluster 25: RPMI-8226 - Immune response" "Cluster 45: Enterocytes - Digestion" "unprognostic (2.21e-2)" "unprognostic (1.65e-4)" "unprognostic (2.54e-1)" "unprognostic (2.06e-1)" "unprognostic (3.39e-2)" "unprognostic (8.03e-4)" "unprognostic (3.55e-3)" "unprognostic (6.71e-3)" "unprognostic (1.89e-1)" "unprognostic (3.57e-1)" "unprognostic (1.69e-1)" "unprognostic (9.32e-2)" "unprognostic (1.64e-4)" "unprognostic (4.90e-2)" "unprognostic (8.92e-2)" "unprognostic (8.97e-2)" "unprognostic (1.02e-1)" 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.3 225.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 136.3 0.0 0.0 0.0 0.0 0.1 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.5 0.0 0.0 4.9 0.8 0.0 0.0 0.0 1.1 0.0 9.7 0.0 0.0 0.4 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 1.4 3.3 0.9 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.3 0.0 0.0 0.1 0.0 0.8 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 1.1 0.0 LIMK1 LIMK ENSG00000106683 "LIM domain kinase 1" P53667 7 74082933-74122525 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Williams-Beuren syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 77.9" "Cell type enhanced" "Detected in many" "Granulosa cells: 27.6;Horizontal cells: 35.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-87 MG: 136.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028516, HPA073571" Approved Supported "Nuclear speckles,Cytosol" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 70: Brain - Nervous system development" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 4: Macrophages - Innate immune response" "Nuclear speckles, Cytosol" "HPA028516: AB_10601751, HPA073571: " "unprognostic (1.45e-2)" "unprognostic (2.75e-1)" "prognostic unfavorable (4.95e-5)" "unprognostic (2.77e-2)" "unprognostic (1.40e-3)" "unprognostic (3.35e-2)" "prognostic unfavorable (7.79e-6)" "unprognostic (1.90e-2)" "unprognostic (2.16e-1)" "unprognostic (1.18e-1)" "unprognostic (3.32e-2)" "unprognostic (3.16e-2)" "prognostic unfavorable (6.63e-8)" "unprognostic (4.14e-2)" "unprognostic (7.00e-2)" "unprognostic (3.84e-2)" "unprognostic (5.79e-2)" 11.1 10.5 31.1 18.7 32.7 6.8 9.4 28.3 77.9 21.4 0.2 8.9 6.6 13.1 3.5 11.3 7.3 10.1 9.4 35.0 43.8 10.8 4.6 13.2 23.5 75.5 40.0 13.2 11.4 5.8 13.9 7.3 73.0 12.3 4.1 4.0 17.9 8.2 23.7 11.4 12.1 7.1 31.8 22.3 9.2 15.6 59.1 8.1 11.2 7.8 18.2 13.1 14.7 38.3 47.4 37.2 27.2 45.4 35.1 47.0 20.0 28.8 27.3 22.6 25.4 21.3 45.6 30.2 12.7 35.5 76.9 28.1 10.1 17.8 8.6 53.7 18.6 23.2 13.1 24.6 40.5 17.2 81.4 46.8 15.6 18.5 9.6 68.3 34.4 20.9 15.1 9.0 28.8 41.4 14.8 31.4 52.1 16.6 23.7 21.1 43.3 18.2 26.5 10.1 10.7 25.2 18.6 43.7 23.5 29.7 13.9 15.4 41.1 36.0 33.7 94.5 47.7 10.2 12.5 54.9 136.5 12.4 25.2 0.1 6.1 3.5 1.8 6.0 1.4 3.4 0.4 1.2 7.0 1.7 0.1 0.5 0.5 5.8 3.8 0.7 0.3 3.3 31.1 32.7 28.3 77.9 35.0 43.8 75.5 40.0 73.0 31.8 59.1 38.3 2.9 3.2 2.7 7.5 14.4 2.9 5.2 6.6 1.8 6.6 7.7 6.9 3.4 7.2 3.8 1.8 2.1 2.5 11.9 2.9 0.0 6.6 1.2 2.7 9.7 4.1 2.4 0.4 15.4 6.5 6.3 9.2 3.1 5.1 5.7 27.6 3.3 2.1 25.0 35.3 20.8 2.7 0.0 13.5 10.8 2.2 7.2 15.6 3.6 6.5 14.9 3.5 22.6 6.6 2.4 13.5 2.3 6.0 10.0 9.0 0.3 2.8 3.1 3.3 0.0 5.3 4.5 3.4 11.5 1.8 3.1 3.7 11.1 6.9 2.4 7.2 LIMK2 ENSG00000182541 "LIM domain kinase 2" P53671 22 31212239-31280080 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 115.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 4 "eosinophil: 40.0;neutrophil: 96.9" "Lineage enriched" "Detected in all" 6 "granulocytes: 96.9" "Cell line enhanced" "Detected in all" "BEWO: 135.5;hTCEpi: 251.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008183, CAB019313, HPA053882" Approved Supported Nucleoplasm,Cytosol NA Yes "Cluster 5: Granulocytes - Unknown function" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm Cytosol "CAB019313: , HPA008183: AB_1079252, HPA053882: AB_2682291" "unprognostic (1.79e-1)" "unprognostic (1.95e-1)" "unprognostic (1.04e-2)" "unprognostic (2.59e-2)" "unprognostic (1.39e-1)" "unprognostic (2.42e-2)" "unprognostic (4.02e-2)" "unprognostic (5.99e-2)" "unprognostic (1.21e-1)" "unprognostic (2.95e-1)" "unprognostic (3.96e-1)" "unprognostic (1.43e-1)" "prognostic unfavorable (4.57e-6)" "unprognostic (4.48e-2)" "unprognostic (1.48e-2)" "unprognostic (5.72e-2)" "unprognostic (1.37e-1)" 20.1 14.4 25.5 39.8 27.3 53.8 30.9 25.8 22.1 26.4 32.6 34.0 21.2 17.0 7.7 71.8 34.2 21.3 14.3 20.8 27.7 27.7 33.0 46.8 23.2 37.8 34.2 21.6 28.8 27.0 21.9 48.0 32.8 36.7 34.7 25.5 50.7 19.1 18.8 71.5 29.3 15.9 32.7 37.5 30.0 19.2 33.6 21.3 42.0 9.2 17.8 25.7 45.3 33.1 26.6 4.4 17.9 10.0 7.6 8.8 135.5 17.2 8.0 16.9 14.2 22.7 12.2 25.8 29.9 26.0 8.1 52.6 20.9 90.3 10.6 19.1 22.8 18.8 21.1 24.7 11.4 35.1 33.1 14.3 251.5 13.7 41.0 114.5 43.6 20.6 10.7 18.2 23.3 20.9 21.5 12.0 16.7 68.3 6.7 28.1 30.0 14.3 19.6 62.3 22.8 20.4 13.0 82.1 35.1 54.8 68.7 13.9 26.6 15.1 23.5 8.3 16.3 10.0 16.2 22.4 9.6 16.4 6.6 5.8 5.1 40.0 3.1 3.5 5.9 2.0 5.7 4.3 1.9 2.4 5.6 4.4 96.9 6.7 1.4 4.4 15.2 4.4 25.5 27.3 25.8 22.1 20.8 27.7 37.8 34.2 32.8 32.7 33.6 33.1 19.5 32.1 17.9 16.3 5.2 35.9 37.7 24.8 59.2 9.4 18.0 23.2 25.1 10.0 32.6 5.5 20.9 69.8 15.3 39.3 3.9 13.0 1.4 49.6 19.2 22.4 13.2 10.3 6.4 45.0 52.4 7.6 48.9 41.6 23.5 8.6 14.3 7.1 18.2 3.3 11.3 42.8 18.3 8.9 8.2 1.6 4.4 13.8 3.6 16.9 5.4 16.6 2.1 2.5 15.5 25.9 21.2 4.5 6.2 27.1 12.0 10.5 36.3 22.8 19.7 7.5 17.2 15.6 18.4 46.1 39.1 115.5 9.3 7.1 51.7 29.9 LOX ENSG00000113083 "Lysyl oxidase" P28300 5 122063195-122078413 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" Oxidoreductase "Aortic aneurysm, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 27.9" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 67.1;Club cells: 38.4;Early spermatids: 41.9;Endometrial stromal cells: 34.0;Extravillous trophoblasts: 44.2;Fibroblasts: 79.1;Peritubular cells: 39.1;Smooth muscle cells: 32.7" "Cancer enhanced" "Detected in all" "renal cancer: 39.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ: 777.3;fHDF/TERT166: 1790.7;HSkMC: 356.3;U-138 MG: 475.5" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" HPA043930 Approved "Endoplasmic reticulum" "Secreted to extracellular matrix" NA NA 550000 "Cluster 82: Adipose tissue - ECM organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 33: Fibroblasts - ECM organization" "Endoplasmic reticulum" "HPA043930: AB_2678736" "unprognostic (5.10e-2)" "unprognostic (1.03e-2)" "unprognostic (6.99e-3)" "unprognostic (3.64e-2)" "unprognostic (9.86e-3)" "unprognostic (1.91e-1)" "prognostic unfavorable (7.38e-4)" "unprognostic (2.42e-3)" "unprognostic (3.06e-3)" "unprognostic (8.92e-2)" "unprognostic (3.21e-3)" "unprognostic (1.91e-1)" "prognostic unfavorable (3.93e-8)" "unprognostic (1.11e-3)" "unprognostic (9.92e-2)" "unprognostic (4.31e-2)" "prognostic unfavorable (3.32e-4)" 27.9 2.4 0.4 6.8 0.4 0.2 17.6 0.5 0.9 10.8 0.8 4.2 3.8 6.2 1.7 5.6 8.9 18.8 23.9 0.3 0.4 4.5 2.1 13.6 3.3 1.3 1.4 5.4 3.3 0.9 1.2 8.1 0.8 4.1 4.5 1.1 3.2 2.6 1.9 12.4 3.7 10.0 1.2 2.6 4.4 1.4 0.5 0.9 6.9 2.1 1.4 14.1 4.8 1.0 0.8 0.2 2.0 0.9 168.7 185.2 0.1 777.3 205.3 73.2 246.4 0.5 0.3 0.1 16.5 1790.7 3.7 0.2 4.5 3.5 196.4 0.1 2.0 0.0 16.3 9.3 203.4 0.4 0.1 356.3 4.4 137.6 7.4 329.3 95.3 0.1 0.0 0.1 83.6 0.0 0.1 0.3 6.4 0.1 1.9 0.1 7.4 0.9 4.9 0.5 0.5 4.2 72.1 0.1 12.9 29.8 0.6 0.6 6.8 475.5 23.2 272.8 9.3 0.0 0.1 0.2 207.1 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.4 0.5 0.9 0.3 0.4 1.3 1.4 0.8 1.2 0.5 1.0 20.0 9.6 1.1 0.0 0.2 7.8 1.9 67.1 0.0 0.6 1.3 1.1 2.1 0.0 38.4 0.0 0.0 0.8 0.1 0.0 0.0 7.2 41.9 8.4 34.0 9.4 0.0 0.0 0.3 0.6 44.2 79.1 0.0 6.6 0.0 0.1 10.8 0.5 2.2 1.7 2.0 0.0 2.0 0.8 21.6 5.0 14.0 1.3 5.4 1.9 0.6 0.0 0.0 0.0 0.0 1.3 0.0 39.1 0.3 2.8 0.0 0.1 8.3 1.7 19.7 1.1 32.7 0.8 0.6 1.8 10.7 4.8 1.1 0.4 0.1 0.9 LOXL2 "LOR, WS9-14" ENSG00000134013 "Lysyl oxidase like 2" Q9Y4K0 8 23296897-23425328 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins" "Transcription, Transcription regulation" "Chromatin regulator, Oxidoreductase, Repressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "smooth muscle: 41.3" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 26.9;Endometrial stromal cells: 26.9;Endothelial cells: 33.1;Extravillous trophoblasts: 22.0;Fibroblasts: 22.9;Hepatic stellate cells: 19.6;Sertoli cells: 26.3;Smooth muscle cells: 48.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ: 935.5;BJ hTERT+ SV40 Large T+ RasG12V: 517.3;fHDF/TERT166: 602.7;TIME: 510.7;U-87 MG: 905.4" "Low region specificity" "Detected in single" "Low region specificity" "Detected in single" "CAB025848, HPA036257, HPA056542" Approved Enhanced Nucleoplasm "Secreted to extracellular matrix" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 46: Fibroblasts - ECM organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 33: Fibroblasts - ECM organization" Nucleoplasm "CAB025848: , HPA036257: AB_2675025, HPA056542: AB_2683168" "unprognostic (9.48e-2)" "prognostic unfavorable (9.83e-6)" "unprognostic (2.03e-1)" "unprognostic (2.81e-2)" "prognostic unfavorable (1.24e-4)" "unprognostic (5.55e-2)" "unprognostic (1.42e-2)" "prognostic unfavorable (1.46e-7)" "unprognostic (2.91e-2)" "unprognostic (3.63e-3)" "prognostic unfavorable (9.05e-4)" "unprognostic (1.25e-1)" "prognostic unfavorable (2.91e-7)" "unprognostic (1.51e-2)" "unprognostic (7.07e-2)" "unprognostic (4.93e-2)" "unprognostic (3.68e-3)" 30.4 3.3 1.9 15.9 2.7 1.2 18.8 4.7 3.0 10.6 0.8 25.3 9.3 12.0 0.9 3.8 4.9 8.0 10.7 1.8 3.2 6.1 3.9 8.3 11.7 7.7 8.1 12.9 6.5 2.5 2.6 36.2 7.0 7.5 5.4 3.0 4.1 13.0 4.5 5.4 10.3 41.3 4.5 5.0 9.0 2.3 4.5 1.8 5.2 2.6 9.5 12.0 7.3 3.7 58.2 147.7 42.7 35.8 112.4 183.8 19.4 935.5 295.9 415.6 517.3 1.1 4.4 10.7 7.5 602.7 193.2 47.6 2.1 79.0 215.3 1.8 8.5 0.9 19.4 1.0 226.8 0.5 3.8 164.6 3.9 155.0 20.8 274.0 350.7 2.4 0.5 2.0 138.1 32.3 0.6 1.4 29.1 0.4 24.5 1.9 36.7 0.4 120.1 0.3 0.9 13.7 122.9 6.1 8.6 131.3 0.8 1.2 510.7 384.6 103.3 163.8 127.3 4.1 0.8 29.9 905.4 1.4 413.5 0.1 0.2 0.8 0.4 0.1 0.2 0.4 0.1 0.3 0.1 0.1 0.2 0.6 0.3 0.1 0.2 0.2 0.1 0.2 1.9 2.7 4.7 3.0 1.8 3.2 7.7 8.1 7.0 4.5 4.5 3.7 12.9 0.0 3.0 6.8 0.6 2.5 0.3 26.9 0.6 1.5 0.6 9.7 2.6 1.5 4.1 0.0 0.0 2.7 0.4 0.0 0.0 1.9 0.6 1.7 26.9 33.1 0.0 0.0 8.1 1.5 22.0 22.9 1.5 2.1 0.0 2.0 19.6 0.2 1.3 1.7 3.2 0.1 0.0 0.3 5.7 0.4 0.9 0.9 3.6 6.5 0.0 1.2 0.0 7.1 11.9 2.3 0.1 0.4 0.9 0.6 0.2 0.2 1.6 3.2 26.3 2.7 48.1 1.3 1.6 0.5 3.1 1.0 1.0 3.1 0.4 0.2 LRRK1 "FLJ23119, KIAA1790, RIPK6, Roco1" ENSG00000154237 "Leucine rich repeat kinase 1" Q38SD2 15 100919327-101078257 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 64.6;Microglial cells: 107.7" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in some" "cerebral cortex: 3.6" "Immune cell enhanced" "Detected in some" "plasmacytoid DC: 1.3" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "U-698: 27.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA010537 Uncertain Supported Mitochondria,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 64: Macrophages - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol Mitochondria "HPA010537: AB_1079283" "unprognostic (3.74e-2)" "unprognostic (1.41e-1)" "unprognostic (2.82e-1)" "unprognostic (3.72e-1)" "unprognostic (6.68e-2)" "unprognostic (6.35e-2)" "unprognostic (1.94e-1)" "unprognostic (4.75e-2)" "unprognostic (3.43e-2)" "unprognostic (3.34e-2)" "unprognostic (2.95e-2)" "unprognostic (8.50e-2)" "prognostic unfavorable (5.71e-5)" "unprognostic (2.92e-2)" "unprognostic (1.82e-2)" "unprognostic (3.13e-1)" "unprognostic (5.25e-2)" 2.9 1.0 1.3 5.8 0.5 6.4 2.3 0.0 3.6 3.8 0.0 5.3 3.8 3.8 1.7 4.5 4.9 3.2 1.4 0.8 0.0 0.9 0.8 3.3 7.2 0.0 0.0 3.8 5.9 2.0 0.9 4.1 0.1 4.0 5.1 0.2 3.9 3.5 1.0 4.7 5.0 3.0 0.0 6.2 3.7 5.2 0.0 2.2 1.6 1.3 7.9 2.9 3.0 1.3 4.5 15.3 0.3 0.0 4.9 3.9 1.8 3.7 7.1 2.3 2.0 3.1 7.2 20.2 4.2 6.3 0.0 17.3 5.2 2.8 2.8 3.1 2.8 17.4 12.8 0.0 2.0 5.2 9.0 3.3 4.7 3.0 6.3 2.3 2.4 0.4 3.6 18.4 1.1 0.4 0.0 4.2 1.4 5.1 5.2 2.9 2.0 15.3 0.0 0.6 0.4 3.3 8.8 2.5 6.2 0.4 1.5 4.4 6.3 0.0 3.1 5.2 0.1 15.9 18.2 27.4 1.1 2.1 6.7 0.0 0.4 1.2 0.0 0.1 0.0 1.0 0.0 0.0 0.4 0.4 0.0 0.0 0.3 0.0 0.4 1.3 0.0 0.0 1.3 0.5 0.0 3.6 0.8 0.0 0.0 0.0 0.1 0.0 0.0 1.3 8.3 16.0 13.6 2.9 17.3 3.2 8.0 3.5 7.4 0.9 5.7 5.1 2.9 2.8 6.0 0.0 6.2 9.6 13.6 19.8 0.0 4.5 3.7 12.6 19.4 8.8 13.8 3.4 64.6 3.3 4.2 11.5 3.6 6.6 1.3 1.4 9.7 0.4 10.7 0.0 10.0 11.7 0.0 24.8 10.1 4.6 32.3 19.9 3.6 107.7 28.3 0.6 1.0 12.5 1.2 7.5 11.4 21.4 14.2 10.7 11.6 0.3 6.3 0.7 6.6 11.2 3.9 6.5 1.5 6.6 3.4 3.6 1.3 2.8 12.5 9.9 LRRK2 "DKFZp434H2111, FLJ45829, PARK8, RIPK7, ROCO2" ENSG00000188906 "Leucine rich repeat kinase 2" Q5S007 12 40196744-40369285 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, Differentiation" "GTPase activation, Hydrolase, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "lung: 52.4" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 502.2;Excitatory neurons: 92.0;monocytes: 133.1;Oligodendrocyte precursor cells: 256.9" "Cancer enhanced" "Detected in many" "renal cancer: 17.1;thyroid cancer: 22.7" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in many" 8 "neutrophil: 58.2" "Lineage enriched" "Detected in many" 8 "granulocytes: 58.2" "Cell line enhanced" "Detected in some" "A549: 4.6;ASC TERT1: 5.6;BJ hTERT+: 3.2;RPTEC TERT1: 7.8;T-47d: 3.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014293, CAB037160" Approved Supported Vesicles NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 11: Alveolar cells - Smell perception" Vesicles "CAB037160: AB_1840989, HPA014293: AB_1853353" "unprognostic (2.67e-1)" "unprognostic (1.75e-1)" "unprognostic (6.45e-3)" "unprognostic (1.06e-1)" "unprognostic (3.00e-2)" "unprognostic (6.10e-3)" "unprognostic (2.71e-1)" "unprognostic (3.14e-1)" "unprognostic (2.25e-1)" "unprognostic (9.07e-2)" "unprognostic (2.76e-1)" "unprognostic (1.23e-1)" "prognostic favorable (3.02e-6)" "unprognostic (2.55e-2)" "unprognostic (3.43e-2)" "unprognostic (2.01e-3)" "unprognostic (5.21e-3)" 4.8 3.1 1.1 10.1 1.9 9.0 2.6 0.9 2.1 5.1 1.2 4.3 0.6 4.8 1.9 7.0 4.1 6.2 3.9 1.3 1.1 10.9 5.6 52.4 6.8 1.7 1.1 5.4 3.6 8.4 2.1 1.2 1.4 2.6 1.8 1.5 3.5 2.0 5.5 2.1 3.6 4.0 1.1 10.8 2.1 0.8 1.2 2.5 2.9 7.9 5.4 4.5 5.5 1.9 0.0 4.6 0.0 0.0 2.3 5.6 0.0 1.3 3.2 0.1 0.1 0.0 0.0 0.0 0.0 0.8 0.1 0.0 0.0 0.0 0.2 0.0 0.3 0.2 0.1 0.0 0.6 0.4 0.0 2.1 0.4 0.0 0.0 2.5 0.4 0.0 0.0 0.0 0.4 0.0 0.0 0.8 0.1 0.0 0.0 0.0 0.0 0.0 7.8 0.0 0.0 0.3 0.0 0.5 2.7 0.1 3.1 1.5 1.0 0.4 0.5 0.6 0.4 0.0 0.0 0.0 1.3 0.0 1.7 0.0 7.2 2.2 0.0 5.2 0.0 1.8 0.0 0.0 2.1 1.7 0.0 0.0 58.2 0.0 6.9 0.3 0.0 1.3 1.1 1.9 0.9 2.1 1.3 1.1 1.7 1.1 1.4 1.1 1.2 1.9 7.4 32.1 502.2 17.3 29.9 2.4 1.8 0.4 2.8 8.6 1.3 1.4 7.8 5.7 17.3 27.6 0.0 0.0 1.9 0.0 1.9 1.3 0.5 0.4 2.6 7.0 0.0 2.1 92.0 2.7 0.1 16.1 0.5 0.4 13.9 2.7 13.2 8.2 4.6 47.1 28.0 0.0 0.0 55.8 8.7 1.2 19.0 52.2 12.4 73.1 133.1 8.6 3.1 256.9 3.1 0.8 1.1 12.0 2.8 0.6 0.0 22.5 3.4 1.0 0.0 22.5 4.8 0.3 1.0 12.6 3.1 0.4 3.4 11.2 0.0 0.7 LRSAM1 "CMT2P, FLJ31641, RIFLE, TAL" ENSG00000148356 "Leucine rich repeat and sterile alpha motif containing 1" Q6UWE0 9 127451489-127503499 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, Protein transport, Transport, Ubl conjugation pathway" Transferase "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 32.0;Excitatory neurons: 28.6;Inhibitory neurons: 26.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021403, HPA021844, CAB037304" Supported Approved Cytosol NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 27: Brain & Skin - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "CAB037304: AB_2138198, HPA021403: AB_1853366, HPA021844: AB_1853368" "unprognostic (8.83e-2)" "unprognostic (3.13e-1)" "unprognostic (7.48e-3)" "unprognostic (4.15e-3)" "unprognostic (9.42e-2)" "unprognostic (2.05e-1)" "unprognostic (1.64e-1)" "unprognostic (5.00e-2)" "unprognostic (1.66e-1)" "unprognostic (2.72e-2)" "prognostic favorable (6.78e-6)" "unprognostic (1.27e-1)" "prognostic favorable (5.72e-4)" "unprognostic (1.94e-2)" "unprognostic (3.26e-1)" "unprognostic (9.07e-2)" "unprognostic (3.33e-2)" 7.2 9.8 8.6 3.4 8.6 2.0 7.3 7.3 12.5 10.7 5.2 16.5 3.4 9.0 5.9 8.7 7.8 3.9 17.3 8.8 8.8 9.0 8.8 7.4 4.5 11.1 7.6 10.7 5.7 6.9 9.0 3.4 11.4 9.1 2.6 2.3 7.5 5.6 13.5 21.2 9.1 5.0 7.0 9.5 9.5 4.3 7.9 3.4 8.8 7.2 3.2 12.3 10.2 9.0 5.7 10.8 4.8 10.7 9.8 9.1 8.3 5.3 8.1 10.0 7.6 8.9 5.9 9.8 5.9 9.9 3.6 18.7 7.8 13.3 3.8 11.5 5.3 5.2 9.0 10.2 9.4 6.2 7.3 6.1 7.9 6.1 12.2 10.7 11.2 7.6 4.8 7.6 4.5 17.6 3.9 4.5 4.7 17.4 9.3 7.1 5.6 18.4 11.5 5.1 9.8 9.2 4.1 12.6 8.8 4.3 26.5 3.2 10.2 4.6 5.6 4.2 2.5 6.2 7.9 1.1 9.1 4.5 2.6 18.5 4.8 21.3 3.7 6.5 4.7 3.7 2.8 3.5 6.1 2.7 1.1 1.4 4.0 1.3 6.8 3.6 2.3 3.8 8.6 8.6 7.3 12.5 8.8 8.8 11.1 7.6 11.4 7.0 7.9 9.0 5.3 9.6 3.9 32.0 5.1 1.1 3.1 2.9 4.6 6.7 5.2 5.0 20.4 4.3 7.3 0.0 6.2 5.0 5.3 6.0 5.9 7.1 0.6 3.6 4.7 4.8 1.2 2.5 28.6 1.4 2.1 4.9 12.2 4.6 9.5 6.6 3.3 7.1 6.3 11.8 26.9 5.8 14.2 5.6 3.7 1.2 2.8 7.4 3.6 10.3 7.4 4.7 3.1 18.1 21.0 4.7 5.0 5.3 3.9 5.0 6.6 5.8 6.0 5.2 0.0 5.1 6.0 5.7 3.6 5.8 2.7 7.0 5.6 3.9 4.8 3.3 LRTOMT "CFAP111, COMT2, DFNB63, LRRC51, LRTOMT1, LRTOMT2" ENSG00000184154 "Leucine rich transmembrane and O-methyltransferase domain containing" Q96E66 11 72080337-72096895 "Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "fallopian tube: 67.1;testis: 49.3" "Group enriched" "Detected in many" 12 "Early spermatids: 574.9;Late spermatids: 2222.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "T-47d: 39.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039949 Approved Uncertain Microtubules NA NA "Cluster 15: NK-cells - Transcription" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 6: T47d - Mammary gland" "Cluster 25: Spermatids - Spermatogenesis" Microtubules "HPA039949: AB_10960708" "unprognostic (2.68e-1)" "unprognostic (6.43e-2)" "unprognostic (1.85e-2)" "prognostic favorable (7.70e-4)" "unprognostic (8.09e-2)" "unprognostic (9.07e-2)" "unprognostic (1.42e-1)" "unprognostic (1.90e-1)" "unprognostic (4.22e-2)" "prognostic favorable (5.36e-4)" "unprognostic (6.12e-2)" "unprognostic (8.43e-2)" "unprognostic (2.64e-2)" "unprognostic (1.58e-1)" "unprognostic (1.34e-1)" "unprognostic (1.67e-1)" "unprognostic (1.44e-1)" 5.0 4.5 21.1 2.5 21.8 2.1 8.7 19.5 24.2 8.7 25.1 5.4 3.7 7.2 17.1 3.8 67.1 3.4 3.7 19.1 19.2 11.7 7.9 7.7 3.2 23.0 25.7 8.1 8.9 10.3 8.9 5.4 21.4 9.3 7.7 19.7 4.4 5.4 7.5 5.8 3.4 5.7 23.4 4.0 5.5 49.3 21.0 4.5 11.0 4.6 3.6 4.1 3.8 22.0 3.9 13.7 8.9 6.9 7.3 6.7 2.1 4.4 3.6 4.0 3.5 6.6 20.4 5.1 6.6 7.8 9.6 7.3 6.3 10.8 4.5 9.4 6.2 3.5 6.3 4.8 1.3 3.0 3.9 2.9 5.4 6.0 4.6 6.4 1.5 10.2 4.0 7.8 6.0 13.6 9.0 6.0 4.4 22.8 3.6 10.8 8.6 7.7 15.9 4.7 8.2 6.2 8.7 19.4 10.4 6.1 39.6 3.3 6.5 4.0 5.7 11.3 3.1 8.0 9.4 5.8 4.0 2.5 4.5 1.8 1.7 3.5 2.0 1.9 1.9 3.2 2.1 1.6 1.0 3.5 1.8 1.8 6.1 6.6 1.3 2.8 4.6 1.4 21.1 21.8 19.5 24.2 19.1 19.2 23.0 25.7 21.4 23.4 21.0 22.0 4.6 0.0 1.5 3.3 2.5 2.3 7.5 10.0 1.8 3.5 8.4 7.5 2.2 5.7 10.7 3.7 12.5 12.7 1.4 4.4 11.7 7.5 574.9 84.3 3.0 6.5 1.2 3.6 2.0 2.5 7.7 5.3 4.1 7.2 0.0 2.2 3.6 6.0 3.1 6.7 1.9 10.8 10.2 1.6 2.8 2222.2 14.9 3.3 1.8 1.9 1.4 21.3 4.1 2.0 3.6 2.0 2.5 10.1 5.1 6.8 4.0 19.9 113.1 16.6 6.6 6.1 7.9 90.3 28.1 2.2 2.4 13.1 1.7 2.9 3.4 6.5 MAK "dJ417M14.2, RP62" ENSG00000111837 "Male germ cell associated kinase" P20794 6 10762723-10838553 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Differentiation, Spermatogenesis, Transcription, Transcription regulation" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 22 "retina: 118.9" "Group enriched" "Detected in many" 5 "Cone photoreceptor cells: 369.1;Early spermatids: 119.7;Rod photoreceptor cells: 330.1" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in single" "Immune cell enriched" "Detected in single" 9 "neutrophil: 6.3" "Lineage enriched" "Detected in single" 9 "granulocytes: 6.3" "Cell line enhanced" "Detected in single" "HDLM-2: 1.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 79: Retina - Phototransduction" "Cluster 44: HDLM-2 - Immune response" "Cluster 9: Photoreceptor cells - Phototransduction" "unprognostic (1.23e-3)" "unprognostic (8.77e-3)" "unprognostic (2.44e-1)" "unprognostic (3.81e-2)" "unprognostic (6.62e-2)" "unprognostic (1.35e-3)" "unprognostic (1.97e-2)" "unprognostic (2.53e-1)" "unprognostic (3.21e-2)" "unprognostic (2.42e-2)" "unprognostic (1.13e-3)" "unprognostic (6.73e-2)" "unprognostic (6.59e-5)" "unprognostic (1.55e-1)" "unprognostic (8.40e-2)" "unprognostic (7.71e-3)" "unprognostic (4.59e-2)" 0.3 0.1 0.2 0.6 0.0 0.6 0.4 1.5 0.4 0.3 5.4 0.0 0.1 0.4 0.0 0.2 5.4 0.4 0.1 0.1 0.0 0.2 0.0 0.7 0.1 0.7 0.9 0.1 0.2 4.6 0.8 0.1 0.1 0.2 0.0 118.9 0.2 0.0 0.1 0.3 0.1 0.0 0.2 0.7 0.3 4.7 0.2 0.0 0.2 0.0 0.1 0.1 0.1 0.4 0.7 0.0 0.3 0.2 0.0 0.0 0.4 0.0 0.0 0.2 0.3 0.0 0.4 0.1 0.1 0.0 0.4 0.1 0.1 0.0 0.1 1.3 0.4 0.0 0.0 0.0 0.0 0.5 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.1 0.4 0.2 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.5 0.2 0.0 0.1 0.0 0.2 0.2 0.1 0.0 0.1 0.2 0.0 0.2 0.2 0.0 0.1 0.0 0.1 0.1 0.4 0.6 0.3 0.3 0.3 0.3 0.1 0.3 0.2 0.3 0.4 0.3 0.5 6.3 0.2 0.6 0.3 0.1 0.1 0.2 0.0 1.5 0.4 0.1 0.0 0.7 0.9 0.1 0.2 0.2 0.4 2.1 0.0 6.4 16.3 1.5 0.4 2.3 0.8 2.8 14.6 4.0 3.9 0.9 0.0 5.3 3.7 369.1 0.5 0.5 0.1 0.0 0.4 119.7 43.3 1.7 1.8 0.0 1.3 45.6 0.2 1.0 2.2 1.1 3.8 2.5 0.3 1.1 0.1 0.2 5.0 39.4 0.0 2.0 0.6 0.7 47.1 0.6 1.3 1.8 12.2 1.3 23.6 0.0 30.7 21.5 0.1 0.0 0.4 1.0 1.1 0.0 0.1 48.9 330.1 0.0 5.4 1.5 15.2 5.5 0.7 0.4 0.8 0.8 0.3 0.0 0.8 MANSC1 "FLJ10298, LOH12CR3" ENSG00000111261 "MANSC domain containing 1" Q9H8J5 12 12326056-12350242 "Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "salivary gland: 70.0" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 15 "neutrophil: 98.3" "Lineage enriched" "Detected in many" 39 "granulocytes: 98.3" "Cell line enhanced" "Detected in many" "HUVEC TERT2: 50.7;OE19: 54.3;RPTEC TERT1: 25.9" "Low region specificity" "Detected in all" "HPA007955, HPA007956" Approved Approved "Golgi apparatus,Vesicles" NA NA 44000000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 21: OE19 - Mitochondria" "Cluster 27: Mucus-secreting cells - Mucin production" "Golgi apparatus, Vesicles" "HPA007955: AB_1079306, HPA007956: AB_1079305" "unprognostic (5.41e-3)" "unprognostic (3.10e-2)" "unprognostic (1.24e-1)" "unprognostic (5.46e-3)" "unprognostic (9.64e-2)" "unprognostic (1.29e-2)" "unprognostic (1.63e-2)" "unprognostic (8.47e-2)" "unprognostic (9.18e-2)" "unprognostic (5.20e-2)" "unprognostic (2.06e-2)" "unprognostic (3.03e-1)" "prognostic favorable (3.30e-5)" "unprognostic (1.15e-2)" "unprognostic (4.46e-2)" "unprognostic (3.65e-1)" "unprognostic (1.03e-2)" 18.9 12.1 3.4 4.3 4.1 3.5 19.5 3.9 6.5 16.9 5.0 22.9 11.7 22.1 11.5 42.3 16.6 10.2 11.2 4.1 3.0 13.2 9.7 12.3 2.3 3.2 3.3 11.3 25.2 11.3 17.9 9.5 3.2 15.1 15.8 5.4 70.0 10.8 4.0 21.7 15.2 12.1 2.6 11.3 21.5 8.4 3.8 1.4 13.8 4.4 6.4 16.3 20.6 4.0 0.3 5.7 1.8 0.1 5.6 5.5 6.2 3.9 4.6 2.0 2.5 4.8 18.2 0.0 4.2 3.9 2.1 0.8 7.1 3.3 1.5 0.0 6.9 8.3 6.4 4.2 0.9 1.4 2.3 3.5 5.3 1.3 0.9 13.8 50.7 0.1 5.6 0.1 0.6 11.0 0.0 0.6 6.5 54.3 3.0 0.2 0.0 0.1 25.9 18.8 2.6 10.3 2.1 16.9 6.0 2.8 15.4 5.0 20.5 2.8 2.3 0.7 5.5 0.4 0.2 2.8 2.0 0.0 2.1 6.6 1.2 1.0 0.1 0.9 0.0 0.2 0.3 0.0 0.6 0.4 2.5 0.4 98.3 0.6 0.4 0.1 0.0 0.6 3.4 4.1 3.9 6.5 4.1 3.0 3.2 3.3 3.2 2.6 3.8 4.0 29.0 9.6 21.2 8.8 3.3 4.0 7.1 7.2 6.2 6.1 21.2 13.5 2.6 28.6 11.9 23.9 8.4 35.4 4.5 33.6 1.9 19.0 0.9 15.1 5.2 28.8 21.7 3.6 16.6 37.9 7.4 10.4 23.0 20.5 2.5 8.6 37.1 9.8 8.0 10.1 13.5 33.4 8.2 5.5 0.7 2.2 13.7 2.0 0.0 15.0 2.7 11.4 9.2 7.5 11.4 16.3 25.2 16.6 1.0 7.4 16.7 3.0 18.1 13.1 0.0 4.8 6.5 2.1 1.5 22.1 4.7 17.0 3.0 9.7 26.5 8.8 MAP2K1 "MAPKK1, MEK1, PRKMK1" ENSG00000169032 "Mitogen-activated protein kinase kinase 1" Q02750 15 66386837-66491544 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Cardiomyopathy, Disease variant, Ectodermal dysplasia, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hepatocytes: 172.5;Langerhans cells: 265.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003834, HPA026430" Approved Enhanced "Plasma membrane,Cytosol" NA NA 120000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 39: Non-specific - Mitochondria" "Cluster 18: U-2197 - ECM organization" "Cluster 41: Macrophages - Immune response" "Plasma membrane, Cytosol" "CAB003834: AB_562310, HPA026430: AB_1853742" "unprognostic (4.05e-2)" "unprognostic (1.23e-2)" "unprognostic (2.07e-1)" "unprognostic (4.92e-2)" "prognostic unfavorable (1.95e-4)" "unprognostic (1.81e-3)" "unprognostic (5.78e-2)" "unprognostic (9.91e-3)" "unprognostic (1.11e-1)" "unprognostic (1.77e-1)" "unprognostic (1.45e-1)" "unprognostic (7.62e-3)" "unprognostic (1.20e-1)" "unprognostic (2.71e-1)" "unprognostic (1.96e-1)" "unprognostic (1.15e-1)" "unprognostic (9.40e-3)" 57.9 31.0 47.6 38.3 79.7 63.7 32.5 30.2 61.3 31.1 22.5 26.5 19.4 26.3 29.6 51.8 23.7 27.0 40.7 69.4 44.3 31.2 105.3 34.7 49.5 31.6 32.6 25.7 22.4 38.5 26.8 29.6 40.1 26.2 23.6 34.1 29.3 21.8 85.5 23.7 27.0 31.9 35.7 32.6 24.1 15.2 42.8 33.8 22.8 51.3 55.4 31.2 33.7 49.9 105.8 55.3 94.4 39.0 55.3 41.3 53.8 83.6 61.6 76.6 68.1 79.0 82.1 96.8 93.2 59.9 58.2 93.3 88.8 106.4 89.8 79.1 56.8 30.9 50.4 40.7 45.1 41.0 45.3 32.3 64.0 55.9 81.6 81.5 60.7 48.0 54.3 116.7 113.4 40.3 33.5 51.9 47.9 93.9 42.9 39.2 58.1 84.7 74.8 48.5 58.3 31.7 60.8 45.5 63.0 74.9 41.0 33.7 90.8 99.5 63.8 71.1 112.4 74.0 143.1 60.6 105.1 69.9 48.4 3.0 7.5 5.4 6.4 7.7 5.8 2.8 5.6 6.1 7.7 4.6 6.9 4.2 3.5 8.3 7.7 15.1 4.6 2.8 47.6 79.7 30.2 61.3 69.4 44.3 31.6 32.6 40.1 35.7 42.8 49.9 24.5 28.9 24.8 24.2 40.0 82.8 45.9 32.3 21.1 10.0 22.2 10.2 21.5 40.0 24.9 25.8 14.6 48.1 45.0 25.1 46.9 69.4 12.1 16.3 13.9 34.6 21.7 19.0 69.7 23.1 48.8 30.3 17.9 35.4 8.9 19.8 18.9 172.5 51.4 10.1 46.4 15.4 20.3 90.7 265.3 23.6 22.4 115.1 53.4 48.7 87.9 34.9 35.0 28.1 31.7 103.9 23.5 21.8 49.1 87.7 22.2 35.9 17.7 7.8 6.6 16.3 52.4 35.6 42.7 30.3 67.3 51.7 54.0 5.9 19.1 65.4 MAP2K2 "MEK2, PRKMK2" ENSG00000126934 "Mitogen-activated protein kinase kinase 2" P36507 19 4090321-4124122 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Cardiomyopathy, Disease variant, Ectodermal dysplasia, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 724.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003835, HPA051993" Supported Supported Cytosol NA NA 140000 "Cluster 52: Eosinophils - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 25: Spermatids - Spermatogenesis" Cytosol "CAB003835: AB_562312, HPA051993: AB_2681685" "unprognostic (4.39e-1)" "prognostic favorable (3.72e-4)" "unprognostic (4.24e-1)" "unprognostic (1.26e-3)" "unprognostic (2.58e-1)" "prognostic favorable (7.98e-4)" "unprognostic (2.08e-3)" "unprognostic (2.11e-1)" "unprognostic (2.65e-1)" "unprognostic (1.06e-1)" "unprognostic (7.45e-3)" "unprognostic (4.95e-2)" "unprognostic (1.32e-1)" "prognostic favorable (5.43e-5)" "unprognostic (2.91e-2)" "unprognostic (2.25e-1)" "unprognostic (4.90e-2)" 73.9 118.4 145.5 54.1 143.1 102.4 69.1 151.5 190.7 76.6 150.4 103.4 134.0 72.3 23.2 121.6 64.7 30.4 156.6 145.9 147.3 82.6 123.3 66.8 57.1 149.6 152.9 84.1 134.3 54.9 99.3 36.4 154.3 93.9 42.7 68.0 79.6 37.6 289.0 95.8 101.0 31.7 143.5 89.1 92.7 131.6 150.7 69.3 74.6 132.1 41.0 77.2 75.2 142.8 163.1 175.4 93.7 132.8 127.1 151.9 93.8 104.5 138.8 139.6 125.8 153.0 85.5 137.7 95.9 120.0 111.9 114.3 74.2 111.6 107.4 118.1 90.4 50.5 91.4 171.7 194.0 93.6 101.8 168.8 106.8 98.2 129.5 185.5 125.2 123.0 98.1 263.1 119.3 203.5 186.3 130.6 107.8 118.6 125.9 140.7 61.9 159.1 123.5 102.7 126.8 126.3 95.7 130.6 344.1 107.3 101.0 158.5 111.8 113.6 98.2 293.4 163.9 263.1 172.4 100.2 176.5 166.8 199.3 27.5 13.0 45.4 16.9 16.6 13.6 13.0 13.3 17.2 15.9 18.2 12.3 15.9 21.2 18.8 14.1 9.0 14.3 7.3 145.5 143.1 151.5 190.7 145.9 147.3 149.6 152.9 154.3 143.5 150.7 142.8 77.7 9.6 31.9 22.5 62.3 35.4 93.3 21.3 15.4 85.1 92.9 95.4 62.9 44.3 22.8 40.5 41.7 28.7 102.3 300.5 146.8 20.7 248.1 59.5 68.3 52.1 63.2 123.1 17.6 45.5 38.6 60.3 64.7 48.8 19.7 124.4 49.2 48.1 55.0 121.1 23.2 107.7 16.2 56.0 38.2 724.3 35.8 65.6 42.7 10.3 28.5 121.1 62.8 13.0 24.2 47.0 151.8 23.0 79.9 103.2 166.1 92.8 18.9 106.8 26.3 93.1 71.8 23.5 17.4 42.9 63.9 35.6 77.0 120.2 119.9 113.1 MAP2K3 "MAPKK3, MEK3, MKK3, PRKMK3" ENSG00000034152 "Mitogen-activated protein kinase kinase 3" P46734 17 21284672-21315232 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 212.4" "Cell type enhanced" "Detected in many" "Erythroid cells: 325.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB018548 Approved Supported Nucleoplasm,Cytosol NA NA 28000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Cytosol" "CAB018548: AB_631927" "unprognostic (2.31e-1)" "unprognostic (6.39e-2)" "unprognostic (4.63e-2)" "unprognostic (3.68e-1)" "unprognostic (3.54e-3)" "unprognostic (1.60e-1)" "unprognostic (2.97e-2)" "unprognostic (1.35e-2)" "unprognostic (5.25e-3)" "unprognostic (1.88e-2)" "unprognostic (3.16e-2)" "unprognostic (2.18e-2)" "unprognostic (1.33e-1)" "unprognostic (6.48e-2)" "unprognostic (1.22e-2)" "unprognostic (2.92e-1)" "unprognostic (1.77e-1)" 47.3 32.5 12.9 35.3 12.1 212.4 30.7 17.6 23.2 22.7 22.6 33.1 49.0 17.1 14.5 62.7 29.9 40.0 66.7 11.5 14.4 45.7 95.7 67.5 34.0 13.6 14.3 12.6 33.6 17.9 37.1 28.9 14.2 28.9 24.1 6.0 45.3 16.5 132.7 53.1 41.0 22.5 14.3 60.4 42.8 6.2 15.8 20.9 24.0 74.6 41.1 54.1 33.4 17.0 75.5 73.9 9.7 44.5 57.7 36.6 36.3 113.0 121.8 88.3 80.5 82.9 46.6 68.1 44.7 178.3 74.2 72.4 31.0 100.5 62.1 69.5 56.9 39.2 42.0 76.1 18.2 51.9 76.7 28.5 28.2 120.6 35.9 27.7 40.0 38.6 7.7 33.2 74.7 74.1 25.5 49.3 28.1 134.1 42.3 53.0 62.2 50.0 50.5 77.4 26.3 9.4 41.7 45.9 82.0 95.7 22.5 17.7 36.8 83.0 68.4 90.1 73.9 39.8 21.8 88.1 80.2 44.3 44.1 54.1 49.3 77.8 35.9 72.1 31.1 33.3 29.1 33.6 49.6 25.5 17.9 24.1 145.6 15.3 104.7 35.4 44.5 35.6 12.9 12.1 17.6 23.2 11.5 14.4 13.6 14.3 14.2 14.3 15.8 17.0 44.2 38.5 53.6 2.6 51.5 258.0 188.4 57.0 97.9 7.1 69.3 51.3 21.9 44.3 50.5 22.0 4.2 73.3 117.4 109.1 74.3 99.1 1.5 130.5 44.8 49.4 120.4 325.0 7.2 79.8 82.0 43.7 68.3 237.8 94.0 11.5 22.1 73.1 49.0 18.5 8.0 77.0 28.5 59.4 278.7 1.8 12.2 118.1 87.2 4.7 48.3 17.3 35.0 5.5 2.0 129.1 135.3 16.6 85.2 158.7 60.8 44.2 40.4 7.4 0.0 61.9 42.4 1.1 5.3 97.3 218.1 67.0 62.6 10.5 58.5 255.7 MAP2K4 "JNKK1, MEK4, MKK4, PRKMK4, SERK1" ENSG00000065559 "Mitogen-activated protein kinase kinase 4" P45985 17 12020829-12143830 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 226.9;Inhibitory neurons: 189.3;Oligodendrocyte precursor cells: 148.3;Oligodendrocytes: 203.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 10.4" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 5 "SuSa: 177.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007751, HPA060074" Enhanced Approved "Nucleoplasm,Cell Junctions" NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 47: Non-specific - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "Cell Junctions" "CAB007751: , HPA060074: AB_2684197" "unprognostic (1.55e-1)" "unprognostic (1.85e-1)" "unprognostic (4.47e-2)" "unprognostic (1.02e-2)" "unprognostic (1.04e-1)" "unprognostic (2.70e-1)" "unprognostic (2.89e-1)" "unprognostic (2.16e-1)" "unprognostic (1.93e-3)" "unprognostic (2.53e-1)" "unprognostic (2.76e-3)" "unprognostic (4.82e-2)" "unprognostic (5.32e-3)" "unprognostic (3.13e-1)" "unprognostic (2.30e-1)" "unprognostic (7.00e-2)" "unprognostic (1.79e-1)" 11.4 13.1 27.3 10.1 30.2 3.6 14.5 18.7 44.8 12.0 8.7 12.0 10.1 12.1 17.5 18.8 11.4 10.9 15.8 32.7 28.5 16.2 21.8 11.7 11.7 30.0 21.8 12.6 11.5 19.4 13.8 15.8 30.9 14.3 13.1 15.4 10.5 12.7 24.1 15.1 10.5 13.8 19.0 11.6 11.2 11.0 25.9 15.2 16.7 28.2 14.4 14.7 13.0 30.1 31.1 26.2 33.8 17.5 18.3 23.5 21.3 20.6 27.1 23.1 21.9 15.6 10.4 12.8 16.4 32.4 15.2 20.2 29.7 28.8 34.3 22.7 33.7 14.2 14.1 29.8 21.4 13.7 20.5 19.6 27.9 27.0 28.0 23.9 21.3 17.8 15.4 7.3 29.4 11.5 16.8 12.9 19.6 33.2 12.4 20.3 37.8 8.9 31.6 19.7 6.8 19.9 23.8 12.7 20.3 177.7 16.1 10.0 19.6 11.3 17.4 15.8 24.9 14.2 16.9 9.9 21.3 10.7 16.8 0.4 2.1 1.7 2.2 1.2 1.9 2.1 1.8 1.8 1.5 2.7 1.5 2.4 10.4 2.7 3.9 1.5 2.2 1.8 27.3 30.2 18.7 44.8 32.7 28.5 30.0 21.8 30.9 19.0 25.9 30.1 13.9 9.6 19.4 71.8 27.1 41.4 36.1 12.7 66.0 15.3 20.4 16.3 22.6 7.2 18.3 14.7 8.4 12.6 17.7 19.1 25.4 12.3 7.2 16.9 16.4 12.0 12.0 14.5 226.9 14.3 10.3 19.4 42.3 27.3 1.3 20.1 11.0 20.8 11.7 18.5 189.3 13.1 20.3 19.9 14.7 8.9 11.8 15.4 12.4 68.4 24.1 11.3 14.4 148.3 203.0 16.9 9.3 12.8 26.9 37.7 11.0 25.2 8.6 10.0 13.1 19.2 20.2 7.3 9.3 56.7 39.2 25.3 20.7 15.0 13.3 41.5 MAP2K5 "HsT17454, MAPKK5, MEK5, PRKMK5" ENSG00000137764 "Mitogen-activated protein kinase kinase 5" Q13163 15 67542703-67807117 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 8 "Astrocytes: 119.5;Early spermatids: 138.1;Excitatory neurons: 201.4;Inhibitory neurons: 169.3;Late spermatids: 212.4;Microglial cells: 87.1;Oligodendrocyte precursor cells: 146.3;Oligodendrocytes: 146.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022094, HPA027347, HPA027755" Supported Approved Nucleoli,Microtubules NA NA "Cluster 15: NK-cells - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoli, Microtubules" "CAB022094: , HPA027347: AB_10599290, HPA027755: AB_10600883" "unprognostic (4.54e-2)" "unprognostic (1.87e-2)" "unprognostic (4.16e-2)" "unprognostic (9.06e-2)" "unprognostic (1.77e-3)" "unprognostic (1.06e-1)" "unprognostic (1.96e-1)" "unprognostic (3.73e-1)" "unprognostic (2.41e-2)" "unprognostic (2.83e-1)" "unprognostic (1.47e-2)" "unprognostic (5.41e-2)" "prognostic favorable (8.03e-5)" "unprognostic (1.68e-1)" "unprognostic (2.74e-1)" "unprognostic (3.99e-2)" "unprognostic (2.73e-2)" 14.3 14.8 9.2 6.3 9.8 10.3 12.4 11.2 14.1 13.2 4.6 15.7 9.2 11.5 6.1 8.7 12.1 8.8 15.0 11.6 9.9 9.9 10.0 9.7 8.5 9.6 6.5 17.2 13.2 18.8 10.2 11.1 9.4 9.4 8.8 11.2 10.5 10.6 23.2 14.5 10.1 8.9 5.6 9.0 11.6 13.8 7.3 17.2 10.6 17.8 7.6 11.8 11.1 12.3 9.0 23.4 13.8 16.3 20.0 34.9 10.9 8.8 17.8 16.3 17.7 9.4 15.8 14.8 18.2 14.8 17.7 13.3 23.8 14.3 13.4 21.6 23.7 20.2 17.0 10.3 25.1 12.3 12.1 23.9 18.3 11.8 26.6 35.7 21.7 33.6 18.0 24.1 13.6 11.6 20.1 14.7 19.4 10.4 11.3 19.7 16.0 24.9 9.8 16.3 8.6 13.4 9.9 14.5 36.5 23.6 18.2 23.7 18.2 16.7 10.9 11.7 12.1 33.7 43.4 17.5 22.4 27.6 12.3 10.9 5.8 5.6 5.6 4.4 8.3 4.8 5.3 6.7 8.1 4.3 7.3 7.0 1.4 9.4 5.4 3.0 6.2 4.4 9.2 9.8 11.2 14.1 11.6 9.9 9.6 6.5 9.4 5.6 7.3 12.3 7.9 6.4 5.8 119.5 10.0 6.9 8.1 3.7 8.6 12.6 8.6 6.1 8.1 5.7 3.2 5.5 10.4 13.4 10.2 13.2 7.9 9.3 138.1 4.4 5.0 7.6 9.5 9.4 201.4 8.5 10.7 9.7 7.7 3.9 2.5 12.3 12.5 8.7 10.0 5.0 169.3 9.2 4.1 10.1 6.1 212.4 12.5 7.9 10.6 87.1 7.2 17.9 11.3 146.3 146.5 7.5 12.5 11.7 5.6 5.3 12.2 9.7 4.0 8.2 0.0 7.9 6.3 11.9 13.0 9.9 8.2 9.9 10.4 11.6 10.4 4.6 MAP2K6 "MAPKK6, MEK6, MKK6, PRKMK6, SAPKK3" ENSG00000108984 "Mitogen-activated protein kinase kinase 6" P52564 17 69414697-69553865 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 40.5" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 53.9;Glandular and luminal cells: 82.7;Oligodendrocytes: 52.5" "Cancer enhanced" "Detected in many" "endometrial cancer: 8.1" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 7 "classical monocyte: 22.0;neutrophil: 45.9;plasmacytoid DC: 78.3" "Group enriched" "Detected in all" 9 "dendritic cells: 78.3;granulocytes: 45.9;monocytes: 22.0" "Cell line enhanced" "Detected in many" "A549: 40.0;AN3-CA: 21.4;HUVEC TERT2: 28.4;MOLT-4: 21.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007744, HPA031134" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Cytosol" "CAB007744: AB_562318, HPA031134: AB_10603016" "prognostic favorable (2.27e-6)" "unprognostic (2.24e-1)" "unprognostic (8.46e-2)" "unprognostic (4.10e-2)" "unprognostic (3.75e-2)" "unprognostic (1.23e-1)" "unprognostic (7.61e-3)" "unprognostic (9.52e-2)" "unprognostic (3.67e-1)" "unprognostic (4.09e-3)" "prognostic favorable (7.52e-4)" "unprognostic (3.61e-2)" "unprognostic (2.29e-2)" "unprognostic (7.48e-2)" "unprognostic (9.43e-2)" "unprognostic (1.39e-1)" "unprognostic (2.03e-2)" 5.2 1.3 4.2 8.4 4.0 15.9 20.4 11.6 4.0 27.0 7.6 30.7 10.3 6.1 3.2 3.1 4.5 7.2 1.4 2.7 6.2 5.5 12.2 1.8 8.0 5.4 3.8 3.1 8.3 0.3 1.6 1.6 3.9 3.3 31.7 5.8 2.5 3.1 40.5 2.0 10.8 3.3 4.4 4.0 7.4 1.3 5.7 11.5 3.3 21.1 5.9 3.3 1.2 7.7 0.1 40.0 17.6 21.4 7.4 4.0 2.5 0.3 5.8 1.6 2.4 1.2 1.7 1.1 14.2 0.8 1.3 1.9 6.1 0.8 0.5 1.3 3.2 0.1 10.3 11.4 7.4 1.7 1.3 19.0 0.5 0.3 0.0 1.4 28.4 5.3 0.1 2.5 0.0 0.3 21.6 0.7 12.5 0.9 7.3 7.7 1.8 0.5 7.8 5.4 7.8 11.8 1.7 1.3 3.9 9.3 5.4 2.3 5.1 1.9 2.3 1.6 0.5 1.7 2.2 0.5 1.6 2.5 1.5 2.5 22.0 4.0 2.8 2.6 5.0 4.1 3.1 3.5 7.1 5.2 3.6 3.4 45.9 4.7 1.1 78.3 5.0 6.2 4.2 4.0 11.6 4.0 2.7 6.2 5.4 3.8 3.9 4.4 5.7 7.7 11.2 3.2 6.7 27.7 7.7 2.7 4.1 0.8 8.6 5.2 14.3 29.1 1.3 5.7 3.6 0.0 2.1 9.7 29.2 42.3 23.5 1.9 10.2 53.9 11.5 7.9 45.6 5.0 26.0 4.1 6.6 5.0 9.2 82.7 1.3 13.4 4.2 2.5 6.2 3.3 22.4 22.9 0.0 6.8 7.4 2.9 4.4 6.9 3.6 24.4 9.6 31.8 10.3 32.6 52.5 1.1 16.7 3.8 10.7 1.3 14.5 1.5 4.2 4.2 0.0 3.9 5.7 0.1 1.8 4.8 4.3 0.8 13.3 1.4 30.6 2.8 MAP2K7 "Jnkk2, MKK7, PRKMK7" ENSG00000076984 "Mitogen-activated protein kinase kinase 7" O14733 19 7903843-7914478 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001633, CAB004262, HPA064711" Supported Approved "Golgi apparatus,Plasma membrane,Cytosol" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 59: Non-specific - Translation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 52: Non-specific - Transcription" "Plasma membrane, Cytosol" "Golgi apparatus" "CAB004262: AB_627925, HPA001633: AB_1079516, HPA064711: AB_2685331" "unprognostic (1.77e-1)" "unprognostic (5.04e-2)" "unprognostic (1.06e-2)" "unprognostic (2.16e-1)" "unprognostic (4.24e-2)" "prognostic favorable (8.54e-5)" "unprognostic (1.80e-3)" "unprognostic (2.55e-1)" "unprognostic (2.69e-2)" "unprognostic (1.69e-2)" "unprognostic (1.27e-3)" "unprognostic (1.56e-1)" "unprognostic (3.54e-2)" "unprognostic (3.71e-2)" "unprognostic (6.05e-2)" "unprognostic (1.73e-2)" "prognostic favorable (1.56e-4)" 19.1 17.0 17.9 11.7 17.8 19.4 19.5 16.8 19.0 25.1 10.4 24.4 13.1 26.1 3.7 20.2 20.5 5.9 20.8 14.8 15.2 18.7 24.7 17.1 11.7 17.3 17.3 23.2 21.6 9.6 23.4 9.2 17.1 21.0 4.6 5.6 19.2 7.9 52.4 27.9 20.1 6.2 15.1 24.5 18.8 17.5 17.3 10.9 19.0 16.4 6.1 22.0 22.4 19.9 25.8 14.4 12.2 20.2 9.7 9.3 22.8 16.5 8.0 11.0 11.3 20.9 15.2 30.5 25.9 8.8 10.7 22.9 10.7 12.8 4.3 24.7 53.3 21.4 20.9 15.6 12.4 20.1 26.0 10.8 16.1 8.7 9.8 14.5 10.0 21.9 31.9 38.5 6.5 13.4 28.8 48.6 21.7 13.6 32.0 28.5 13.4 31.0 9.8 21.0 22.4 22.5 11.3 19.4 23.9 7.3 21.0 22.7 15.3 33.2 19.0 23.7 22.7 55.5 27.7 28.8 16.6 29.2 13.6 0.0 0.8 0.6 0.6 0.8 0.4 0.7 0.5 0.6 0.4 1.0 0.5 0.7 1.5 1.0 0.5 0.8 0.2 0.4 17.9 17.8 16.8 19.0 14.8 15.2 17.3 17.3 17.1 15.1 17.3 19.9 15.4 25.6 18.1 11.1 27.0 38.6 37.2 22.7 22.2 52.9 23.5 16.5 14.4 24.3 14.5 20.2 77.2 28.3 27.8 31.1 13.7 22.8 4.8 16.2 20.3 19.5 36.5 23.6 9.9 19.0 31.1 18.5 16.3 24.8 10.8 33.3 21.4 22.2 18.6 57.2 11.0 24.0 32.6 22.2 17.1 11.7 28.9 20.5 32.0 6.5 25.3 23.9 46.4 9.0 15.0 25.7 20.8 12.4 30.4 39.8 38.7 18.4 15.3 65.7 32.9 30.2 22.1 17.7 36.4 22.7 42.6 49.3 30.3 30.3 27.6 33.2 MAP3K1 "MAPKKK1, MEKK, MEKK1" ENSG00000095015 "Mitogen-activated protein kinase kinase kinase 1" Q13233 5 56815549-56896152 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocyte precursor cells: 210.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "SH-SY5Y: 52.5;THP-1: 51.0" "Region enriched" "Detected in all" 6 "olfactory bulb: 18.2" "Low region specificity" "Detected in all" "CAB004500, HPA046509" Approved Approved Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 57: B-cells - Immune response" Cytosol "CAB004500: AB_627926, HPA046509: AB_2679678" "unprognostic (1.77e-1)" "unprognostic (1.71e-2)" "unprognostic (4.09e-1)" "unprognostic (2.18e-1)" "unprognostic (3.48e-2)" "unprognostic (5.39e-3)" "unprognostic (5.20e-3)" "unprognostic (2.52e-2)" "unprognostic (1.35e-1)" "unprognostic (1.41e-1)" "unprognostic (1.05e-2)" "unprognostic (6.73e-2)" "unprognostic (1.97e-3)" "unprognostic (2.18e-2)" "unprognostic (1.58e-1)" "unprognostic (9.92e-3)" "unprognostic (1.11e-1)" 5.5 3.8 3.0 13.3 2.6 24.0 20.1 4.0 2.1 7.0 6.2 5.4 6.3 7.5 6.6 10.0 9.7 5.7 3.7 2.1 2.7 9.9 6.0 7.5 18.1 3.9 3.2 7.2 9.8 7.1 1.3 11.4 3.7 5.4 6.3 26.9 18.5 8.3 1.7 19.7 6.5 5.7 3.8 20.5 8.1 8.3 3.5 9.9 16.2 4.4 24.0 6.7 6.4 3.9 13.3 7.9 12.1 8.1 1.9 1.5 20.3 2.5 3.3 7.6 10.6 37.1 9.7 11.9 0.9 3.0 6.5 6.7 10.1 4.6 10.5 4.0 4.4 6.6 3.4 17.5 4.7 10.6 17.6 1.9 4.8 2.4 3.8 2.1 3.3 4.0 5.8 20.7 2.0 5.8 7.4 14.2 5.6 6.8 1.0 11.5 8.6 41.1 13.2 13.6 5.1 52.5 7.6 9.5 21.5 10.7 26.0 51.0 9.8 0.7 6.4 2.9 4.7 15.0 8.2 22.1 1.2 6.1 13.2 6.3 3.1 0.7 0.8 4.5 0.7 4.0 2.4 1.1 1.8 3.3 1.5 0.5 1.7 1.7 4.9 1.0 3.8 1.7 3.0 2.6 4.0 2.1 2.1 2.7 3.9 3.2 3.7 3.8 3.5 3.9 20.8 6.4 9.8 17.9 102.5 52.4 15.1 17.1 43.9 14.9 73.2 30.6 3.5 48.6 15.9 36.8 47.9 15.1 31.9 7.3 7.9 18.9 2.0 25.0 20.6 24.0 10.2 14.5 11.7 14.8 8.6 10.7 14.3 43.7 7.6 20.0 21.8 15.0 32.3 28.6 31.8 11.4 6.1 76.0 48.4 3.6 5.3 66.5 37.4 69.3 99.1 11.6 9.2 210.1 12.5 12.9 7.7 1.9 41.5 14.8 10.6 20.7 11.0 38.5 6.6 9.3 11.9 8.6 17.9 69.1 54.7 6.7 31.6 15.4 9.7 12.0 MAP3K10 "MEKK10, MLK2, MST" ENSG00000130758 "Mitogen-activated protein kinase kinase kinase 10" Q02779 19 40191426-40215575 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 46.2" "Cell type enhanced" "Detected in many" "Excitatory neurons: 18.9;Horizontal cells: 23.5" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in many" 8 "amygdala: 22.8;basal ganglia: 17.5;cerebral cortex: 46.2;hippocampal formation: 37.7;white matter: 11.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007039 Approved Approved "Nucleoplasm,Actin filaments,Cytosol" NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 62: Horizontal cells - Visual perception" "Nucleoplasm, Actin filaments, Cytosol" "HPA007039: AB_1079357" "unprognostic (2.09e-1)" "unprognostic (3.77e-2)" "unprognostic (1.42e-3)" "unprognostic (2.03e-2)" "unprognostic (2.04e-1)" "prognostic favorable (8.69e-4)" "unprognostic (4.50e-3)" "unprognostic (1.80e-1)" "unprognostic (3.94e-2)" "unprognostic (6.13e-2)" "unprognostic (1.34e-3)" "unprognostic (4.62e-3)" "unprognostic (6.88e-2)" "unprognostic (1.53e-2)" "unprognostic (1.51e-2)" "unprognostic (4.77e-3)" "prognostic favorable (2.13e-4)" 6.9 8.3 22.8 2.3 17.5 1.9 6.5 0.0 46.2 7.7 0.0 8.6 2.0 7.9 0.3 5.3 6.6 1.8 10.7 37.7 0.1 7.4 5.2 6.7 2.3 3.2 0.6 7.3 6.9 3.3 14.3 1.6 0.0 8.1 0.6 1.4 5.9 2.0 16.8 7.1 6.3 1.8 0.0 8.1 7.1 11.1 2.4 1.8 6.9 4.3 0.9 7.2 6.6 11.6 6.3 7.2 2.2 5.2 2.0 1.2 6.2 4.3 2.0 1.9 1.9 1.7 1.7 5.7 4.4 1.4 4.6 1.9 0.8 2.2 0.2 10.9 6.8 1.4 3.3 1.7 3.8 1.2 3.4 1.1 5.0 2.0 1.4 2.0 1.7 7.6 5.5 9.1 0.5 3.7 4.5 2.2 2.6 2.0 4.7 5.8 2.3 3.4 1.7 3.8 7.4 10.7 4.9 1.7 10.0 1.3 2.4 2.2 2.9 4.9 4.8 7.3 8.3 12.7 7.7 2.6 5.7 2.3 7.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 22.8 17.5 0.0 46.2 37.7 0.1 3.2 0.6 0.0 0.0 2.4 11.6 5.6 0.0 0.0 6.5 4.2 1.5 1.8 1.1 1.2 14.9 2.9 2.4 2.8 5.7 0.5 7.3 8.4 0.9 3.3 2.4 0.0 2.5 2.8 2.4 3.6 3.6 4.2 5.3 18.9 4.3 0.8 2.6 5.6 3.8 0.0 10.3 3.9 3.2 2.5 23.5 15.9 1.7 0.0 1.6 2.9 7.6 3.1 2.7 1.8 9.4 2.5 5.7 4.1 9.0 12.4 3.7 2.9 4.9 1.5 2.5 1.7 3.1 0.6 7.7 6.6 4.5 4.0 4.1 1.8 1.8 2.7 1.4 4.4 3.2 2.4 2.0 MAP3K11 "MEKK11, MLK3, PTK1, SPRK" ENSG00000173327 "Mitogen-activated protein kinase kinase kinase 11" Q16584 11 65597756-65615382 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 123.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB010165 Approved Supported "Centriolar satellite,Cytosol" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 53: Intestinal epithelial cells - Unknown function" "Centriolar satellite, Cytosol" "CAB010165: AB_631936" "unprognostic (8.36e-2)" "unprognostic (1.17e-2)" "unprognostic (1.06e-1)" "unprognostic (9.99e-2)" "unprognostic (3.40e-1)" "unprognostic (1.87e-1)" "unprognostic (7.56e-3)" "unprognostic (3.10e-2)" "unprognostic (4.50e-2)" "unprognostic (4.30e-1)" "unprognostic (4.69e-2)" "unprognostic (2.77e-2)" "unprognostic (3.13e-2)" "unprognostic (2.01e-2)" "unprognostic (7.62e-2)" "unprognostic (1.95e-1)" "unprognostic (8.27e-3)" 47.6 32.6 39.9 36.9 51.7 24.4 42.9 45.1 48.4 27.2 27.2 40.0 48.3 29.7 7.4 35.6 31.3 13.5 53.2 36.1 38.8 48.5 95.3 62.7 23.7 48.8 50.3 21.0 35.8 12.1 27.8 21.6 44.6 39.2 11.7 2.8 29.1 12.6 20.1 35.9 51.0 10.0 41.5 78.3 36.3 21.3 50.5 19.3 37.3 10.4 11.3 29.2 28.3 60.1 48.0 43.4 23.1 22.6 7.0 8.0 21.7 19.3 11.9 19.9 14.9 43.4 43.9 16.4 65.5 13.0 33.0 40.9 12.2 19.5 7.1 40.2 15.5 50.0 28.2 50.9 18.6 28.9 71.2 12.4 19.1 14.5 13.3 21.6 57.4 21.5 21.6 32.7 10.9 58.2 34.0 50.9 24.2 31.0 48.1 56.1 13.3 36.2 19.2 43.1 19.6 22.9 22.0 58.1 107.7 10.4 46.6 45.8 68.8 31.3 35.8 48.1 32.4 23.3 27.5 15.8 35.3 33.1 75.1 7.5 10.5 13.1 3.1 15.3 3.0 2.7 3.2 4.5 10.1 3.0 2.4 1.8 17.3 2.4 15.4 3.0 1.8 9.5 39.9 51.7 45.1 48.4 36.1 38.8 48.8 50.3 44.6 41.5 50.5 60.1 70.0 22.4 21.1 4.2 22.1 21.0 25.3 18.4 20.5 24.4 28.9 23.4 8.7 31.5 14.1 11.0 25.0 24.7 26.4 123.5 19.6 21.9 13.5 15.4 11.3 78.9 41.9 13.0 4.1 27.5 17.7 11.4 44.4 26.1 26.0 19.6 58.5 56.2 53.3 18.5 3.5 54.9 20.3 50.6 65.5 68.5 9.6 48.3 21.4 21.5 50.2 16.1 23.7 3.0 29.5 33.7 99.0 6.4 15.5 28.1 113.1 27.6 10.3 54.7 32.9 10.5 12.8 12.2 18.3 24.8 30.0 34.3 24.0 28.9 55.2 34.6 MAP3K12 "DLK, MEKK12, MUK, ZPK, ZPKP1" ENSG00000139625 "Mitogen-activated protein kinase kinase kinase 12" Q12852 12 53479669-53500063 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Rod photoreceptor cells: 85.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "ASC diff: 55.9;HHSteC: 53.7;HSkMC: 51.8;hTERT-RPE1: 69.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039936, HPA071996" Enhanced Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 35: Non-specific - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 46: Photoreceptor cells - Phototransduction" "Nucleoplasm, Plasma membrane" "HPA039936: AB_10795239, HPA071996: AB_2686481" "unprognostic (4.01e-1)" "unprognostic (3.30e-1)" "unprognostic (8.89e-3)" "unprognostic (6.40e-3)" "unprognostic (1.10e-1)" "unprognostic (2.22e-1)" "unprognostic (6.97e-2)" "unprognostic (3.61e-2)" "unprognostic (2.39e-1)" "unprognostic (2.70e-1)" "prognostic favorable (1.51e-4)" "unprognostic (8.50e-3)" "prognostic unfavorable (5.43e-10)" "unprognostic (1.65e-2)" "unprognostic (2.44e-1)" "unprognostic (1.32e-1)" "unprognostic (1.18e-1)" 12.6 7.6 12.9 5.4 15.2 3.2 10.3 25.9 19.6 23.5 4.3 13.3 3.2 22.9 4.8 4.0 18.5 14.0 8.6 15.6 11.3 8.5 1.7 11.2 4.4 11.9 11.1 21.6 3.6 7.3 22.7 6.4 13.2 9.6 3.8 13.6 4.9 10.9 2.7 5.7 8.9 14.4 8.0 9.0 7.3 9.0 13.0 6.0 8.6 6.3 2.7 14.0 12.2 13.7 0.5 15.1 8.6 14.2 55.9 28.9 1.2 10.1 18.9 10.8 11.0 0.3 1.8 3.5 5.4 10.8 8.7 0.1 4.3 6.8 4.3 4.9 5.4 3.5 8.3 0.0 53.7 0.1 3.6 51.8 5.2 14.6 7.8 69.1 16.9 7.8 0.1 15.7 10.0 6.7 3.8 0.9 3.2 0.0 5.5 5.4 6.3 1.0 5.4 0.1 9.3 12.4 5.6 6.8 14.9 1.8 4.6 10.3 12.9 10.2 10.8 4.5 2.5 6.1 8.0 0.0 16.8 6.9 10.4 0.0 0.5 0.0 0.4 0.4 0.8 0.1 0.5 0.6 0.2 0.0 0.2 0.3 1.0 0.2 0.1 0.0 0.1 0.1 12.9 15.2 25.9 19.6 15.6 11.3 11.9 11.1 13.2 8.0 13.0 13.7 11.4 6.4 14.6 21.5 8.1 0.8 2.4 0.5 4.6 28.9 5.6 5.2 0.8 7.2 6.4 1.8 37.5 1.9 12.2 4.8 9.8 6.7 1.5 11.5 27.6 10.4 3.5 1.3 21.1 1.8 2.2 11.0 2.0 15.8 12.7 7.0 15.0 7.8 4.1 30.3 19.1 2.8 2.0 10.3 2.2 1.8 8.1 8.6 0.0 8.4 8.5 19.9 5.2 10.6 11.0 4.4 2.1 8.2 6.7 5.3 7.1 14.8 5.5 85.0 6.6 23.5 10.2 2.5 2.1 2.5 1.0 2.2 11.6 12.5 4.1 3.9 MAP3K13 "LZK, MEKK13" ENSG00000073803 "Mitogen-activated protein kinase kinase kinase 13" O43283 3 185282941-185489094 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016497, HPA036691, HPA036692" Uncertain Approved "Nucleoplasm,Centriolar satellite,Cytosol" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 68: Epididymis - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 22: Epithelial cell types - Mixed function" "Centriolar satellite" "Nucleoplasm, Cytosol" "HPA016497: AB_10670027, HPA036691: AB_10673661, HPA036692: AB_10670845" "unprognostic (8.95e-2)" "unprognostic (6.72e-3)" "unprognostic (9.46e-2)" "prognostic unfavorable (1.28e-5)" "unprognostic (5.16e-2)" "unprognostic (2.81e-1)" "unprognostic (2.61e-1)" "unprognostic (1.23e-2)" "unprognostic (9.04e-2)" "prognostic favorable (1.11e-4)" "prognostic unfavorable (7.27e-5)" "unprognostic (2.70e-3)" "unprognostic (1.54e-2)" "unprognostic (2.94e-2)" "unprognostic (2.82e-1)" "unprognostic (6.64e-2)" "unprognostic (9.31e-3)" 14.7 34.0 18.5 13.0 19.8 15.8 21.0 23.2 25.8 17.0 18.5 24.6 24.3 17.9 56.8 19.7 20.2 18.1 10.4 19.7 20.4 30.9 29.6 17.5 11.7 20.7 21.7 22.2 25.9 34.6 20.7 13.1 21.1 19.7 26.2 36.2 26.2 14.9 4.7 14.0 25.0 17.0 21.2 13.1 23.9 18.8 21.5 11.1 25.7 6.8 15.0 23.2 15.8 23.5 73.9 14.5 27.4 0.7 24.4 29.9 16.1 16.5 11.2 26.2 31.5 27.9 27.0 0.6 55.1 30.4 43.7 41.1 0.8 38.4 46.5 82.1 36.8 0.3 18.9 23.3 26.5 39.2 20.1 27.2 32.8 22.6 28.1 27.1 29.6 0.7 0.9 57.5 23.8 23.0 4.6 18.2 31.5 56.5 33.4 0.6 32.8 40.5 46.9 18.8 44.7 29.8 28.0 41.5 59.9 29.8 62.8 21.5 19.7 21.5 27.8 39.4 36.5 29.3 40.8 24.4 31.4 19.5 36.1 14.0 21.6 9.4 16.6 22.1 25.7 42.8 19.6 21.0 37.4 34.9 27.2 26.6 35.9 20.8 15.9 16.4 8.6 12.4 18.5 19.8 23.2 25.8 19.7 20.4 20.7 21.7 21.1 21.2 21.5 23.5 69.5 54.5 82.7 80.0 41.8 141.6 219.1 196.7 100.7 117.9 144.0 115.1 25.2 144.4 131.6 79.1 91.8 139.5 22.9 96.1 287.6 106.6 134.8 76.5 50.7 65.9 106.4 43.8 170.7 127.5 38.9 49.0 72.4 73.1 29.8 96.6 93.5 99.4 64.9 45.4 184.5 130.9 138.4 53.2 193.0 213.0 43.2 52.7 85.4 28.1 283.9 137.5 22.6 102.1 89.8 137.5 95.1 54.2 40.6 322.2 111.6 283.9 125.7 88.8 46.0 38.5 62.7 119.5 39.1 94.6 145.6 203.4 32.2 50.0 109.3 279.4 MAP3K14 "FTDCR1B, HS, HSNIK, NIK" ENSG00000006062 "Mitogen-activated protein kinase kinase kinase 14" Q99558 17 45263119-45317029 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "monocytes: 33.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "A549: 40.6;U-251 MG: 43.1" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA027269, HPA027270" Approved Supported "Nucleoplasm,Nucleoli fibrillar center,Vesicles,Cytosol" NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 59: Non-specific - Translation" "Cluster 9: U-2 OS - Unknown function" "Cluster 3: Monocytes - Immune response regulation" "Vesicles, Cytosol" "Nucleoplasm, Nucleoli fibrillar center" "HPA027269: AB_2732436, HPA027270: AB_2732437" "unprognostic (1.05e-2)" "prognostic favorable (5.27e-5)" "unprognostic (2.71e-2)" "unprognostic (9.42e-2)" "unprognostic (5.31e-2)" "unprognostic (2.61e-3)" "unprognostic (2.70e-2)" "unprognostic (1.72e-1)" "unprognostic (3.40e-1)" "unprognostic (3.45e-1)" "unprognostic (1.07e-2)" "unprognostic (1.78e-1)" "prognostic unfavorable (2.78e-4)" "unprognostic (8.82e-2)" "unprognostic (3.49e-2)" "unprognostic (1.03e-2)" "unprognostic (2.28e-1)" 5.9 4.7 2.6 12.5 5.0 5.2 6.4 2.9 2.3 7.1 2.8 15.6 8.1 5.7 1.9 7.8 6.6 5.9 9.9 3.2 2.7 5.1 7.3 8.1 17.7 3.6 4.6 6.0 8.3 4.6 5.9 2.7 3.1 7.0 5.2 2.2 8.1 4.7 28.0 8.5 10.3 5.9 2.5 12.4 7.6 6.9 4.8 13.4 5.8 9.9 16.0 7.2 7.1 2.1 17.1 40.6 3.6 6.5 2.4 7.1 9.4 4.5 3.4 14.9 9.1 5.5 21.0 7.4 24.1 5.3 14.6 11.6 1.5 6.5 7.6 24.3 3.1 1.4 10.1 2.1 7.1 1.1 6.9 10.0 3.6 7.3 3.6 15.6 3.0 3.2 2.7 30.1 8.1 6.1 6.8 1.7 1.8 11.1 5.1 9.5 12.1 17.9 10.5 2.6 3.5 3.0 7.6 3.4 5.0 5.5 2.8 0.4 5.6 6.5 10.2 5.7 43.1 29.1 12.1 4.1 3.9 4.0 9.2 0.0 2.0 0.8 1.6 1.8 1.0 4.2 1.1 1.0 1.4 4.4 1.2 0.9 1.6 2.0 0.6 1.7 2.9 1.6 2.6 5.0 2.9 2.3 3.2 2.7 3.6 4.6 3.1 2.5 4.8 2.1 5.8 3.2 12.8 23.5 15.3 0.0 14.7 0.0 14.8 4.5 5.6 4.8 2.3 18.6 2.5 0.0 4.2 0.9 14.5 13.9 0.0 4.8 4.7 7.0 4.0 6.1 13.1 1.3 8.9 2.7 1.5 6.3 10.2 5.6 1.3 2.1 6.4 9.2 4.9 1.7 15.6 7.8 0.0 9.4 0.0 6.2 4.7 11.3 0.0 26.2 33.4 1.9 5.2 6.6 5.5 3.3 9.6 1.2 8.5 6.2 13.4 3.8 5.1 2.9 0.0 12.9 2.8 4.2 3.0 7.9 0.0 0.0 10.6 2.4 8.5 6.8 MAP3K15 "ASK3, bA723P2.3, FLJ16518" ENSG00000180815 "Mitogen-activated protein kinase kinase kinase 15" Q6ZN16 X 19360056-19515261 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 7 "adrenal gland: 10.8;choroid plexus: 13.1" "Cell type enhanced" "Detected in some" "Collecting duct cells: 5.5;Cone photoreceptor cells: 4.2;Granulosa cells: 7.5;Theca cells: 29.8" "Cancer enhanced" "Detected in single" "testis cancer: 0.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 2.0;HAP1: 4.9;HEK 293: 4.1;JURKAT: 2.5;REH: 2.6;SuSa: 4.7" "Low region specificity" "Detected in many" "Low region specificity" "Detected in some" HPA004006 Approved Vesicles NA NA "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 52: Non-specific - Transcription" Vesicles "HPA004006: AB_1079358" "unprognostic (2.87e-1)" "unprognostic (7.09e-2)" "unprognostic (3.21e-2)" "unprognostic (6.56e-8)" "unprognostic (3.47e-2)" "unprognostic (1.42e-2)" "unprognostic (2.19e-3)" "unprognostic (2.35e-2)" "unprognostic (1.46e-1)" "unprognostic (4.87e-2)" "unprognostic (1.30e-2)" "unprognostic (8.95e-2)" "unprognostic (2.77e-3)" "unprognostic (4.00e-1)" "unprognostic (2.37e-1)" "unprognostic (3.98e-2)" "unprognostic (8.20e-2)" 0.0 10.8 0.1 0.0 0.0 0.3 0.0 0.1 0.0 0.0 13.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.6 1.1 0.0 0.3 0.0 0.0 0.3 0.4 0.5 0.7 0.5 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.6 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.1 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.3 0.0 4.9 0.0 0.0 0.8 4.1 1.7 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.3 0.0 0.0 0.1 0.0 1.1 1.3 0.0 0.5 2.6 0.0 0.0 0.3 0.0 0.1 0.1 0.0 0.0 0.0 4.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.7 0.6 0.0 0.3 0.4 0.0 0.2 0.0 0.2 0.0 3.1 0.3 0.0 0.1 0.5 0.0 0.0 1.0 0.2 0.6 2.9 0.0 0.0 5.5 4.2 0.0 0.1 0.2 3.9 0.0 0.4 0.3 0.3 0.1 0.0 0.4 2.6 0.0 0.3 0.4 0.0 0.3 0.0 7.5 0.4 0.0 0.1 0.0 2.5 0.0 0.0 0.0 0.0 0.2 0.3 0.2 0.0 1.0 0.0 0.3 0.0 0.5 1.1 0.1 0.0 1.2 0.0 0.2 0.0 0.1 0.0 0.6 0.0 0.3 0.2 0.6 1.4 0.0 0.0 0.1 0.2 29.8 0.1 0.0 MAP3K2 "MEKK2, MEKK2B" ENSG00000169967 "Mitogen-activated protein kinase kinase kinase 2" Q9Y2U5 2 127298730-127388465 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 11.3" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021540 Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 44: HDLM-2 - Immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" "Nucleoplasm, Cytosol" "HPA021540: AB_2670742" "unprognostic (5.81e-2)" "unprognostic (2.76e-1)" "unprognostic (1.58e-1)" "unprognostic (9.46e-2)" "unprognostic (1.02e-1)" "unprognostic (5.76e-2)" "unprognostic (7.19e-2)" "unprognostic (4.50e-1)" "unprognostic (1.27e-1)" "unprognostic (4.00e-1)" "unprognostic (1.25e-1)" "unprognostic (1.39e-1)" "unprognostic (4.97e-3)" "unprognostic (7.56e-2)" "unprognostic (8.93e-2)" "unprognostic (8.88e-2)" "unprognostic (2.11e-1)" 12.6 8.9 12.1 13.4 16.3 37.6 10.5 13.5 15.9 12.0 9.9 12.5 15.3 11.2 8.3 9.5 9.0 12.9 6.6 10.3 14.3 11.9 22.3 10.8 12.9 18.0 14.9 10.6 10.6 14.0 7.8 9.9 17.4 8.9 10.1 15.6 10.2 9.0 13.4 12.6 14.1 12.7 15.2 13.5 14.7 11.3 18.3 14.4 17.9 9.1 13.8 10.4 8.3 24.8 29.4 12.3 9.6 9.7 13.2 17.4 16.0 17.9 19.4 17.2 13.9 14.8 12.7 19.2 30.0 25.7 16.0 24.3 15.6 12.0 19.3 48.6 12.1 17.9 22.3 13.0 15.2 18.2 37.2 15.7 12.9 21.0 25.5 15.1 8.1 14.2 8.6 37.3 17.2 10.7 21.4 12.9 9.9 8.2 15.8 14.0 18.0 14.5 7.0 27.1 19.0 10.2 26.1 15.8 16.4 7.8 10.3 13.7 18.7 33.6 31.3 15.7 24.5 38.4 30.0 19.5 16.1 11.7 14.8 3.4 2.5 1.7 1.3 1.5 1.6 2.7 1.2 1.3 2.1 2.2 1.5 1.6 11.3 2.0 2.0 4.2 1.1 1.0 12.1 16.3 13.5 15.9 10.3 14.3 18.0 14.9 17.4 15.2 18.3 24.8 45.7 83.3 46.0 53.8 88.9 72.0 36.9 34.3 55.2 53.6 42.2 32.1 30.1 45.8 44.2 29.5 106.3 20.5 107.9 72.6 13.7 21.2 4.6 77.0 71.0 36.9 45.4 27.8 60.6 34.0 19.8 54.9 42.3 90.2 60.9 42.2 25.4 69.1 47.7 72.3 57.7 40.1 30.5 80.1 113.7 7.6 42.3 107.7 56.9 50.6 79.1 25.9 30.9 49.8 87.7 49.0 28.8 51.9 57.3 48.3 54.5 33.1 58.5 59.2 19.7 69.2 47.4 42.3 52.6 43.5 78.6 26.3 65.5 51.7 31.8 46.1 MAP3K20 "MLK7, MLTK, MLTKalpha, MLTKbeta, MRK, ZAK" ENSG00000091436 "Mitogen-activated protein kinase kinase kinase 20" Q9NYL2 2 173075435-173268015 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 261.9;tongue: 279.7" "Cell type enhanced" "Detected in many" "Adipocytes: 57.5;Alveolar cells type 2: 57.7;Cytotrophoblasts: 52.6;Endometrial stromal cells: 96.7;Granulosa cells: 100.7;Smooth muscle cells: 83.2;Theca cells: 70.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "myeloid DC: 15.5" "Group enriched" "Detected in many" 5 "dendritic cells: 15.5;monocytes: 9.4" "Cell line enhanced" "Detected in many" "U-138 MG: 176.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017205 Approved Supported Cytosol NA Yes "Cluster 28: Myeloid DCs - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 7: Non-specific - Mitochondria" Cytosol "HPA017205: AB_1858933" "unprognostic (2.90e-2)" "unprognostic (9.99e-3)" "unprognostic (4.63e-3)" "unprognostic (1.98e-1)" "unprognostic (7.63e-2)" "unprognostic (5.02e-2)" "unprognostic (2.34e-2)" "unprognostic (3.89e-3)" "unprognostic (2.83e-2)" "unprognostic (9.27e-2)" "unprognostic (4.54e-2)" "unprognostic (1.74e-1)" "prognostic unfavorable (3.41e-6)" "unprognostic (2.34e-1)" "unprognostic (1.86e-1)" "unprognostic (2.23e-1)" "unprognostic (1.19e-2)" 71.0 11.4 9.5 20.5 9.7 4.7 21.4 10.3 8.5 44.9 15.7 65.8 13.0 76.4 18.6 50.0 48.0 31.4 195.7 9.3 12.1 7.5 25.2 22.5 9.8 13.8 14.7 69.5 11.7 49.3 3.8 27.6 11.2 44.0 20.9 2.5 12.4 57.1 261.9 14.1 19.2 75.0 11.1 12.5 31.5 10.6 12.5 11.5 16.4 279.7 10.2 56.1 21.2 9.4 34.6 28.6 22.0 29.1 62.7 92.5 13.8 121.9 94.7 55.9 59.6 19.5 22.2 26.5 31.2 122.5 48.8 22.9 33.1 64.6 124.2 52.0 22.0 43.3 30.5 4.1 24.8 39.3 43.8 74.7 27.2 105.2 164.2 46.3 37.5 28.5 19.8 4.9 36.8 14.8 24.8 19.0 12.2 28.9 16.0 36.2 45.0 0.1 13.6 19.6 12.9 12.4 47.0 11.3 19.7 35.6 12.9 20.9 37.9 176.3 71.4 53.1 27.9 0.1 0.1 5.5 126.2 10.6 18.9 0.2 9.4 0.0 1.0 8.3 1.0 1.6 0.8 1.7 15.5 2.5 0.0 0.8 2.6 0.5 8.2 0.3 0.8 3.4 9.5 9.7 10.3 8.5 9.3 12.1 13.8 14.7 11.2 11.1 12.5 9.4 57.5 38.5 57.7 0.0 2.8 0.0 0.0 0.0 0.0 0.0 20.0 44.4 0.0 0.0 7.4 11.0 0.0 52.6 2.3 0.0 1.9 43.9 0.0 36.7 96.7 14.1 0.0 0.0 0.0 27.6 21.9 36.5 0.0 35.6 5.1 100.7 0.0 0.0 19.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.2 0.0 0.0 15.5 0.0 0.0 0.0 0.0 38.6 0.0 0.0 1.4 0.0 0.0 1.9 13.1 0.0 0.0 0.0 83.2 0.0 0.0 0.0 0.0 21.6 3.6 70.5 0.0 0.0 MAP3K21 "KIAA1804, MLK4" ENSG00000143674 "Mitogen-activated protein kinase kinase kinase 21" Q5TCX8 1 233327724-233385148 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pancreas: 20.3" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 35.3;Alveolar cells type 2: 10.0;Collecting duct cells: 14.7;Ductal cells: 11.9;Exocrine glandular cells: 9.8;Glandular and luminal cells: 11.7;Proximal tubular cells: 12.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 5 "NK-cell: 1.5" "Lineage enriched" "Detected in single" 5 "NK-cells: 1.5" "Cell line enhanced" "Detected in many" "HEK 293: 27.4" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" HPA007636 Uncertain Approved "Plasma membrane,Cytosol" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 29: Non-specific - Vesicular transport" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 11: Alveolar cells - Smell perception" "Plasma membrane, Cytosol" "HPA007636: AB_1079392" "unprognostic (3.29e-2)" "unprognostic (5.10e-2)" "unprognostic (2.00e-1)" "unprognostic (2.42e-3)" "unprognostic (4.30e-2)" "unprognostic (1.23e-1)" "unprognostic (1.82e-2)" "unprognostic (1.84e-1)" "unprognostic (1.51e-1)" "unprognostic (1.25e-1)" "unprognostic (2.09e-1)" "unprognostic (8.21e-2)" "unprognostic (3.76e-2)" "unprognostic (2.23e-1)" "unprognostic (1.71e-1)" "unprognostic (9.22e-2)" "unprognostic (4.84e-2)" 0.7 3.8 1.8 1.3 1.6 2.1 2.5 5.2 2.4 1.0 0.7 6.3 11.7 1.2 3.3 2.5 4.6 1.7 0.4 1.4 1.4 13.5 5.4 4.5 0.9 1.5 0.3 0.7 20.3 4.3 2.1 0.3 1.7 1.3 6.9 1.0 3.8 2.7 0.0 3.3 10.1 0.6 0.2 0.5 12.4 9.4 1.8 0.4 2.3 0.0 1.3 1.2 1.8 1.3 11.6 19.4 0.4 0.0 0.0 0.0 9.6 0.3 0.0 0.4 0.8 10.8 9.8 1.1 7.7 0.2 3.6 6.0 14.4 5.9 1.2 21.6 27.4 0.1 11.4 0.0 0.7 19.0 4.3 0.2 7.8 0.3 10.9 2.2 0.7 8.7 0.2 3.7 0.0 2.6 6.1 6.8 13.6 13.4 8.4 0.0 0.0 20.7 13.1 4.8 13.9 3.7 6.6 0.3 0.0 1.5 5.6 6.0 0.0 0.0 1.8 0.1 11.5 3.4 4.6 0.0 1.8 5.1 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.1 0.0 0.0 0.0 1.5 0.0 0.1 0.0 0.0 1.8 1.6 5.2 2.4 1.4 1.4 1.5 0.3 1.7 0.2 1.8 1.3 0.9 35.3 10.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 7.0 6.5 0.0 0.0 0.6 14.7 0.0 0.0 0.4 0.0 3.9 11.9 0.0 5.7 1.0 0.3 0.0 0.0 0.0 9.8 0.0 0.5 0.0 11.7 0.0 2.5 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 1.0 0.0 0.0 0.0 0.0 7.6 0.0 0.0 0.7 0.0 0.0 12.9 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.3 0.7 0.0 0.0 0.0 MAP3K3 "MAPKKK3, MEKK3" ENSG00000198909 "Mitogen-activated protein kinase kinase kinase 3" Q99759 17 63622415-63696305 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007764, HPA035410, HPA035411" Uncertain Approved Nucleoplasm NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Nucleoplasm "CAB007764: AB_562314, HPA035410: AB_2674614, HPA035411: AB_2674615" "unprognostic (9.65e-3)" "unprognostic (1.33e-1)" "unprognostic (5.14e-2)" "prognostic unfavorable (1.13e-4)" "unprognostic (1.16e-1)" "unprognostic (4.12e-2)" "unprognostic (1.03e-2)" "unprognostic (1.33e-1)" "unprognostic (1.36e-1)" "unprognostic (9.37e-2)" "unprognostic (1.46e-3)" "unprognostic (5.51e-2)" "unprognostic (2.35e-1)" "unprognostic (2.79e-2)" "unprognostic (4.68e-2)" "unprognostic (1.09e-1)" "unprognostic (3.08e-2)" 30.1 12.3 11.3 23.7 12.4 31.5 23.6 13.9 12.3 21.6 13.6 28.8 8.7 23.8 6.5 17.7 24.2 21.8 40.9 10.5 12.1 22.9 13.9 28.7 22.3 14.9 12.7 24.0 12.9 15.2 13.8 22.9 13.2 22.2 8.5 6.9 15.1 18.4 23.7 19.3 18.7 22.0 13.1 34.5 18.7 17.2 12.9 15.1 18.0 30.3 14.5 23.4 19.1 13.6 22.6 16.3 20.4 20.1 37.7 30.2 9.4 22.0 24.4 27.0 21.2 7.8 4.5 24.2 15.0 43.2 18.7 8.3 13.4 15.5 16.9 21.7 29.3 19.6 22.6 11.0 19.5 15.6 20.1 22.3 10.4 33.6 17.1 16.3 65.7 17.4 12.2 31.1 21.4 15.9 27.3 15.9 12.5 4.5 16.8 14.3 53.0 15.6 9.4 10.3 10.6 25.3 14.6 17.1 17.9 24.9 17.3 14.8 60.5 67.8 17.8 37.3 26.9 30.3 33.6 8.9 14.4 12.0 18.0 15.0 11.4 15.3 2.8 11.8 3.0 2.0 3.4 2.8 4.9 2.4 3.3 3.2 25.1 1.9 12.5 1.9 2.9 3.5 11.3 12.4 13.9 12.3 10.5 12.1 14.9 12.7 13.2 13.1 12.9 13.6 31.6 19.2 14.5 23.5 11.0 7.8 5.4 3.9 5.7 15.8 9.5 8.9 10.3 12.8 5.1 16.5 14.6 3.2 25.8 3.3 9.8 4.5 8.3 10.0 12.3 33.0 4.2 2.1 39.8 8.1 3.3 13.6 3.1 9.3 3.8 7.1 48.2 10.1 16.3 18.5 34.2 3.9 2.0 47.1 13.0 6.4 14.9 35.1 23.2 54.4 42.7 8.8 24.7 31.2 36.1 5.2 1.9 13.2 8.3 8.2 3.7 2.4 5.4 14.0 19.7 21.9 12.9 23.9 17.8 6.1 11.2 1.4 15.6 6.2 4.5 3.8 MAP3K4 "KIAA0213, MAPKKK4, MEKK4, MTK1" ENSG00000085511 "Mitogen-activated protein kinase kinase kinase 4" Q9Y6R4 6 160991727-161117385 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Oligodendrocyte precursor cells: 87.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 31.5" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007625 Uncertain Approved Cytosol NA NA "Cluster 34: Basophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 1: K-562 - Erythropoiesis" "Cluster 44: Endometrium - Transcription" Cytosol "HPA007625: AB_1853770" "unprognostic (3.05e-3)" "unprognostic (2.19e-2)" "unprognostic (1.36e-1)" "unprognostic (1.44e-1)" "unprognostic (2.06e-1)" "unprognostic (7.65e-2)" "unprognostic (1.35e-3)" "unprognostic (6.38e-2)" "unprognostic (2.09e-1)" "unprognostic (3.81e-3)" "unprognostic (2.09e-2)" "unprognostic (2.61e-1)" "unprognostic (1.16e-2)" "unprognostic (5.86e-2)" "unprognostic (3.45e-1)" "unprognostic (1.93e-1)" "unprognostic (6.84e-2)" 4.9 3.9 5.1 6.4 4.4 5.8 6.0 9.4 7.7 7.8 0.0 6.0 5.3 9.3 3.6 8.5 7.2 4.5 5.5 6.4 4.8 5.0 4.5 6.2 7.3 2.7 2.0 8.6 6.4 8.0 3.9 7.1 3.6 7.3 5.3 4.1 7.3 6.3 11.1 8.5 5.5 7.6 2.7 6.3 5.8 7.5 3.1 9.6 5.5 10.2 9.8 7.1 6.7 5.6 8.1 9.0 16.8 14.7 9.9 11.9 11.1 9.0 7.9 10.2 10.7 12.6 5.8 16.7 6.4 23.2 14.6 19.7 17.4 18.0 12.4 12.4 14.3 21.8 8.5 12.9 7.9 22.9 10.1 7.6 20.5 10.7 9.6 15.8 13.5 12.4 56.1 18.8 11.0 8.3 15.6 11.9 10.3 5.8 13.8 16.9 15.6 13.3 9.0 5.8 9.7 8.5 17.0 17.8 1.5 14.7 7.4 27.6 13.0 12.4 15.9 11.7 43.3 10.8 9.3 15.3 14.6 23.2 13.2 31.5 4.0 2.7 5.2 3.2 9.3 6.7 7.5 4.8 4.9 9.1 5.2 5.2 0.2 4.1 1.9 6.1 5.7 3.0 5.1 4.4 9.4 7.7 6.4 4.8 2.7 2.0 3.6 2.7 3.1 5.6 19.9 19.2 12.2 32.7 20.8 9.8 10.5 9.7 30.7 18.5 13.3 16.8 20.9 10.0 14.9 14.7 22.9 20.6 17.0 7.1 3.9 9.7 5.5 35.3 55.4 14.5 15.4 12.8 66.1 7.5 11.5 16.1 15.8 39.4 3.8 35.3 6.1 8.3 7.3 23.5 64.5 9.3 6.1 8.2 6.4 4.4 11.5 15.3 0.0 45.9 18.8 14.9 10.3 87.4 57.1 12.5 8.1 12.4 18.2 13.6 9.3 6.9 10.6 29.8 6.6 21.8 19.4 14.7 25.7 28.1 11.8 33.1 25.2 8.1 11.7 16.7 MAP3K5 "ASK1, MAPKKK5, MEKK5" ENSG00000197442 "Mitogen-activated protein kinase kinase kinase 5" Q99683 6 136557046-136792477 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Immunity, Innate immunity, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 88.1" "Cell type enhanced" "Detected in many" "Astrocytes: 383.6;Excitatory neurons: 170.4;Inhibitory neurons: 204.8;Microglial cells: 216.4;Oligodendrocyte precursor cells: 210.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+: 42.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007824, HPA063245" Supported Supported Cytosol NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 35: Non-specific - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "CAB007824: AB_598175, HPA063245: AB_2684969" "unprognostic (1.37e-1)" "unprognostic (3.21e-2)" "unprognostic (2.85e-2)" "unprognostic (1.38e-1)" "unprognostic (3.19e-1)" "prognostic favorable (6.08e-4)" "unprognostic (8.76e-2)" "unprognostic (1.41e-2)" "unprognostic (2.84e-1)" "unprognostic (1.90e-2)" "prognostic unfavorable (5.91e-4)" "unprognostic (3.97e-1)" "unprognostic (3.75e-2)" "unprognostic (1.37e-1)" "unprognostic (2.72e-1)" "unprognostic (2.72e-2)" "unprognostic (6.59e-3)" 13.2 88.1 21.7 11.7 23.6 14.1 9.5 21.6 18.9 8.4 7.0 8.7 7.3 11.3 7.7 10.0 12.9 7.5 11.3 18.6 18.9 10.6 9.0 11.9 12.1 17.2 20.7 49.3 30.9 1.9 16.2 5.3 16.1 18.0 9.7 14.5 7.1 7.1 6.3 8.0 9.0 5.1 16.6 11.7 14.8 12.0 24.8 8.2 12.8 6.1 12.3 18.5 9.2 15.7 5.6 3.4 0.0 0.0 7.6 20.2 1.9 8.0 42.6 4.0 3.8 0.3 5.6 3.3 11.5 11.1 3.0 7.6 13.6 4.1 10.5 4.6 10.6 28.9 7.6 0.0 36.3 13.6 0.1 26.8 5.3 6.3 17.9 15.4 13.6 4.1 7.3 31.2 28.7 10.9 0.3 11.6 1.3 10.9 4.5 7.6 8.9 13.2 16.2 35.3 9.7 6.4 6.6 6.3 1.8 1.4 1.4 12.0 12.0 6.7 2.1 0.4 7.5 25.3 18.0 0.0 5.3 18.6 6.0 3.5 1.8 2.1 1.5 1.4 2.9 1.1 2.5 2.2 1.5 1.5 0.2 0.8 5.2 2.3 1.4 1.5 4.6 0.9 21.7 23.6 21.6 18.9 18.6 18.9 17.2 20.7 16.1 16.6 24.8 15.7 11.9 6.4 22.0 383.6 14.3 5.0 20.5 32.0 3.4 18.2 10.0 5.0 21.2 4.3 35.1 11.0 6.2 1.0 25.9 12.3 3.9 3.0 6.4 17.3 31.4 7.7 34.8 14.9 170.4 23.1 1.1 12.1 20.9 62.5 5.7 67.7 9.7 11.2 8.0 0.0 204.8 18.2 14.2 23.5 10.2 4.2 23.6 26.6 0.0 216.4 21.7 43.3 12.3 210.1 4.2 17.8 8.7 14.3 13.5 18.8 7.2 8.3 20.5 2.6 13.1 5.3 17.9 3.4 15.5 13.1 10.1 2.7 18.5 16.2 11.2 23.4 MAP3K6 "ASK2, MAPKKK6, MEKK6" ENSG00000142733 "Mitogen-activated protein kinase kinase kinase 6" O95382 1 27354067-27366961 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Adipocytes: 45.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in single" "Low region specificity" "Detected in single" HPA051192 Approved Approved "Nucleoplasm,Plasma membrane,Actin filaments,Cytosol" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Nucleoplasm "Plasma membrane, Actin filaments, Cytosol" "HPA051192: AB_2681380" "unprognostic (1.19e-2)" "unprognostic (2.77e-3)" "unprognostic (2.62e-2)" "unprognostic (1.97e-2)" "prognostic unfavorable (2.13e-4)" "prognostic favorable (7.26e-4)" "prognostic unfavorable (8.76e-4)" "unprognostic (9.10e-2)" "unprognostic (2.79e-1)" "unprognostic (6.91e-2)" "unprognostic (6.56e-2)" "unprognostic (1.25e-1)" "unprognostic (4.65e-3)" "unprognostic (4.95e-2)" "unprognostic (2.79e-1)" "unprognostic (7.07e-3)" "unprognostic (1.50e-1)" 42.9 17.8 17.2 5.5 17.0 0.6 42.6 17.4 20.7 50.2 16.8 25.4 1.8 30.9 4.1 70.0 38.8 4.7 61.8 16.6 17.4 37.3 10.4 54.2 4.7 18.4 17.5 15.6 15.2 5.2 18.0 5.1 17.6 41.3 4.5 1.4 30.3 7.3 15.2 65.7 17.7 12.1 17.3 22.3 23.6 8.3 18.4 2.8 30.3 11.3 7.9 39.8 53.4 16.6 7.2 7.2 6.9 4.4 9.9 12.5 1.4 9.0 5.3 7.2 4.4 2.0 9.4 0.1 8.4 16.4 3.2 10.1 2.0 6.4 3.6 6.5 7.1 0.3 16.0 4.7 2.7 0.5 0.4 10.2 17.6 7.8 2.3 8.8 4.0 0.7 2.0 2.7 10.2 25.1 0.2 9.0 2.2 8.7 8.1 2.3 3.2 1.7 12.9 9.1 2.0 3.0 8.5 7.1 6.3 3.1 4.4 5.0 11.6 13.2 7.2 16.6 5.2 3.5 4.1 0.0 12.1 5.8 4.3 0.9 0.6 3.3 2.8 2.0 3.7 1.5 2.5 3.1 1.3 2.0 1.8 1.6 1.2 0.7 4.5 0.0 3.0 1.2 17.2 17.0 17.4 20.7 16.6 17.4 18.4 17.5 17.6 17.3 18.4 16.6 45.8 19.2 17.8 6.2 3.9 12.5 11.9 8.8 17.1 1.1 8.1 8.9 12.2 5.7 10.3 3.7 0.0 1.2 4.3 8.4 3.9 2.8 0.4 2.3 6.0 27.7 0.0 0.8 1.5 4.4 2.5 10.3 8.6 5.2 2.5 1.2 28.9 0.9 2.8 5.0 1.7 6.1 4.1 8.5 7.1 1.2 16.1 6.4 5.4 5.6 9.3 5.4 8.2 0.0 0.2 12.8 1.9 15.1 3.1 9.5 1.1 1.7 6.2 0.8 6.6 10.8 11.1 13.5 7.7 14.7 14.8 0.1 8.2 0.3 8.8 14.9 MAP3K7 "MEKK7, TAK1" ENSG00000135341 "Mitogen-activated protein kinase kinase kinase 7" O43318 6 90513573-90587072 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 137.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007633, HPA075335" Approved Supported "Nuclear speckles,Plasma membrane,Cytosol" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 21: Non-specific - Transcription" "Cluster 1: K-562 - Erythropoiesis" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "Nuclear speckles, Plasma membrane" "HPA007633: AB_1079359, HPA075335: " "unprognostic (1.48e-1)" "unprognostic (3.45e-2)" "unprognostic (1.35e-1)" "unprognostic (6.48e-2)" "unprognostic (1.44e-1)" "unprognostic (1.84e-1)" "prognostic unfavorable (3.51e-4)" "unprognostic (9.77e-2)" "unprognostic (6.51e-2)" "unprognostic (1.98e-2)" "unprognostic (1.44e-1)" "unprognostic (2.79e-1)" "unprognostic (2.56e-3)" "unprognostic (4.76e-2)" "unprognostic (1.95e-1)" "unprognostic (2.08e-1)" "unprognostic (1.17e-1)" 11.8 12.5 13.1 12.5 15.1 8.7 14.3 15.6 17.3 14.3 11.7 11.6 9.2 16.6 16.5 10.6 11.0 12.7 16.9 14.7 14.9 11.4 11.6 10.4 16.4 15.3 13.7 15.8 9.7 16.3 13.0 17.4 15.8 14.9 10.9 23.5 12.1 13.3 16.9 13.9 9.8 14.0 15.3 17.6 10.8 9.9 13.8 20.8 14.7 18.4 16.8 14.3 12.2 22.4 16.7 14.4 41.3 35.6 29.5 39.1 29.0 32.7 37.7 28.8 36.1 18.6 15.5 36.9 20.4 35.6 25.6 17.3 26.3 25.5 48.7 19.0 27.7 32.9 19.9 24.9 30.8 36.9 24.4 32.5 30.5 28.2 34.2 33.1 27.4 31.8 67.0 29.3 41.8 20.3 17.2 31.2 34.0 25.7 18.0 29.3 73.9 18.0 24.2 18.4 20.8 29.5 22.9 15.6 24.8 32.2 15.5 64.7 26.5 23.3 14.7 21.6 30.9 25.9 24.7 15.8 35.7 39.7 35.0 18.2 11.5 18.4 12.8 15.9 14.5 13.0 12.3 12.5 14.6 9.9 13.7 13.4 11.5 17.9 17.6 8.9 20.8 13.4 13.1 15.1 15.6 17.3 14.7 14.9 15.3 13.7 15.8 15.3 13.8 22.4 16.1 16.0 26.9 47.0 24.3 36.3 20.8 19.5 21.6 23.3 17.9 12.3 31.0 14.3 16.9 16.5 27.1 31.8 17.8 12.4 7.9 17.6 3.6 10.9 19.8 21.2 12.1 14.1 85.7 20.9 34.6 23.2 16.3 14.8 13.9 25.9 25.7 20.7 24.3 28.6 63.8 13.7 20.3 27.3 24.6 3.2 26.8 21.7 21.4 36.5 35.2 19.6 16.5 50.8 137.2 20.1 9.1 41.0 18.8 30.1 11.1 16.6 21.4 21.5 19.7 28.0 18.5 25.9 24.9 21.3 37.2 48.4 22.7 18.1 15.1 24.8 MAP3K8 "c-COT, COT, EST, ESTF, MEKK8, Tpl-2" ENSG00000107968 "Mitogen-activated protein kinase kinase kinase 8" P41279 10 30434021-30461833 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Immunity" "Kinase, Serine/threonine-protein kinase, Transferase" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 5 "bone marrow: 332.1" "Cell type enhanced" "Detected in many" "Macrophages: 225.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HMC-1: 44.2" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" "CAB005120, HPA017962" Supported Supported Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 41: Macrophages - Immune response" Cytosol "CAB005120: AB_2140669, HPA017962: AB_1853776" "unprognostic (1.91e-2)" "unprognostic (2.94e-1)" "unprognostic (3.07e-1)" "unprognostic (9.29e-2)" "unprognostic (6.73e-2)" "unprognostic (1.00e-2)" "unprognostic (1.44e-1)" "unprognostic (3.36e-2)" "unprognostic (1.41e-2)" "unprognostic (8.04e-3)" "unprognostic (8.23e-2)" "unprognostic (2.96e-1)" "prognostic unfavorable (8.76e-7)" "unprognostic (1.88e-1)" "unprognostic (1.49e-1)" "unprognostic (1.63e-2)" "unprognostic (5.98e-3)" 69.1 18.8 7.2 39.9 5.8 332.1 31.8 5.9 8.0 15.1 22.1 19.6 8.3 18.3 5.9 23.2 38.0 37.4 18.5 6.7 13.5 12.7 16.2 64.5 33.7 10.7 8.1 12.0 7.4 6.9 8.4 46.5 8.8 11.1 16.4 10.9 12.5 11.2 6.6 36.0 21.1 35.6 9.3 41.7 20.3 3.0 15.9 9.3 14.7 6.1 28.8 49.4 20.4 7.9 15.5 13.7 3.6 7.7 18.3 15.4 17.3 3.8 20.3 8.2 9.6 9.4 34.2 10.3 9.2 8.1 8.1 28.2 8.4 3.7 3.0 23.3 4.4 19.2 25.6 30.8 16.0 6.0 44.2 19.5 2.1 7.4 1.6 7.7 3.6 0.2 8.8 14.7 1.4 8.8 0.2 22.3 1.4 8.3 4.9 1.3 3.0 5.8 7.9 30.8 0.3 1.6 13.7 11.3 1.9 10.0 3.7 12.7 0.1 4.8 4.3 18.0 0.6 22.4 22.7 3.2 6.9 25.3 0.2 45.8 14.7 53.1 15.7 26.4 8.7 20.8 3.3 10.3 14.5 38.0 0.2 6.0 35.5 28.3 38.7 30.0 1.0 10.3 7.2 5.8 5.9 8.0 6.7 13.5 10.7 8.1 8.8 9.3 15.9 7.9 51.0 38.5 49.6 11.8 147.3 116.9 50.0 91.1 109.8 19.0 51.7 24.3 10.1 11.5 67.5 3.7 0.0 29.3 203.6 13.6 1.9 31.4 0.5 149.3 51.4 55.7 12.0 21.2 7.7 11.3 86.8 66.2 33.1 205.6 71.1 1.1 25.0 3.1 128.2 0.0 7.1 6.3 83.4 113.8 205.5 1.1 8.4 225.1 42.7 30.9 64.7 6.1 36.0 2.0 0.7 23.4 20.7 4.1 107.8 46.8 3.9 3.5 78.8 1.6 6.6 23.6 62.3 0.3 0.8 129.1 84.8 159.4 97.8 1.5 6.5 195.6 MAP3K9 "MEKK9, MLK1, PRKE1" ENSG00000006432 "Mitogen-activated protein kinase kinase kinase 9" P80192 14 70722526-70809534 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 22.7;retina: 9.6" "Cell type enhanced" "Detected in many" "Excitatory neurons: 49.6;Inhibitory neurons: 58.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 22.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000942 Approved Approved Nucleoplasm,Nucleoli "Intracellular and membrane" NA NA "Cluster 6: Brain - Smell perception" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Nucleoli" "HPA000942: AB_1079360" "unprognostic (1.20e-1)" "unprognostic (3.75e-1)" "unprognostic (4.01e-2)" "unprognostic (1.43e-2)" "unprognostic (3.16e-3)" "unprognostic (2.45e-2)" "unprognostic (3.75e-5)" "unprognostic (2.58e-1)" "unprognostic (4.20e-2)" "unprognostic (4.38e-2)" "unprognostic (1.53e-2)" "unprognostic (2.48e-2)" "unprognostic (4.23e-6)" "unprognostic (5.71e-3)" "unprognostic (6.86e-3)" "unprognostic (1.79e-1)" "unprognostic (2.35e-1)" 0.2 1.0 3.3 1.0 4.6 0.7 1.3 10.7 22.7 0.9 0.4 1.5 1.5 0.4 1.5 5.1 1.0 0.4 0.5 4.0 3.2 1.4 0.7 1.9 1.4 8.6 3.0 0.6 2.2 2.7 1.1 0.6 7.7 0.9 1.5 9.6 1.7 0.5 0.8 4.0 1.4 0.2 0.3 0.9 1.6 5.5 10.0 0.9 2.7 0.4 3.6 0.7 1.8 6.8 22.3 10.5 2.0 2.5 0.0 0.0 6.7 0.5 0.3 2.1 1.9 7.8 8.6 4.5 2.8 0.1 4.7 10.3 6.5 12.8 2.2 3.0 1.7 0.2 4.1 5.2 0.3 0.5 0.9 0.1 6.5 1.5 12.7 3.7 0.0 4.1 1.7 1.0 0.5 9.4 3.7 0.5 4.2 9.0 4.5 1.3 3.9 0.9 4.6 10.9 13.8 3.0 6.3 7.7 1.2 3.7 6.9 0.8 0.0 0.0 8.5 0.0 3.5 2.2 5.6 2.4 3.4 0.4 1.4 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.3 0.1 0.1 0.2 0.2 0.0 0.0 0.2 0.0 3.3 4.6 10.7 22.7 4.0 3.2 8.6 3.0 7.7 0.3 10.0 6.8 0.3 6.4 13.4 6.8 3.9 8.7 13.7 9.4 6.8 17.7 11.2 4.8 2.3 14.3 12.4 7.3 12.5 2.8 1.7 5.7 1.9 6.1 19.8 7.4 0.7 0.8 8.4 0.0 49.6 4.8 1.6 1.0 4.1 8.5 1.3 1.8 1.1 4.8 1.2 30.3 58.1 4.0 4.1 0.8 1.9 20.0 0.6 0.8 3.6 5.6 0.4 3.2 0.0 8.5 1.3 11.1 3.9 0.0 2.8 15.8 2.6 2.8 7.1 12.7 0.0 0.8 1.3 8.0 8.4 12.6 9.1 4.0 3.7 6.0 5.8 27.9 MAP4K1 HPK1 ENSG00000104814 "Mitogen-activated protein kinase kinase kinase kinase 1" Q92918 19 38587641-38618882 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 30.1;lymphoid tissue: 56.9" "Cell type enhanced" "Detected in many" "B-cells: 42.6;dendritic cells: 42.6;Langerhans cells: 27.8;Plasma cells: 30.4;Rod photoreceptor cells: 77.9;T-cells: 43.6" "Cancer enhanced" "Detected in all" "testis cancer: 15.2" "Low region specificity" "Detected in some" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "Daudi: 45.2;HDLM-2: 46.4;Karpas-707: 46.9;REH: 25.5;RPMI-8226: 29.8;U-266/70: 36.0;U-266/84: 38.2;U-698: 57.8" "Not detected" "Not detected" "Low region specificity" "Detected in some" "HPA007419, CAB007754" Enhanced Approved "Plasma membrane" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 58: T-cells - T-cell receptor" "Plasma membrane" "CAB007754: AB_562299, HPA007419: AB_1853778" "unprognostic (1.99e-3)" "prognostic favorable (6.17e-5)" "unprognostic (9.50e-3)" "unprognostic (3.27e-1)" "unprognostic (6.03e-2)" "prognostic favorable (3.26e-4)" "unprognostic (4.88e-3)" "unprognostic (5.32e-3)" "unprognostic (2.79e-1)" "unprognostic (2.51e-1)" "unprognostic (3.92e-2)" "unprognostic (2.55e-1)" "prognostic unfavorable (7.99e-10)" "unprognostic (1.72e-1)" "unprognostic (1.83e-1)" "unprognostic (3.18e-2)" "unprognostic (1.50e-2)" 2.7 1.5 0.6 14.6 0.7 9.2 1.7 0.7 1.2 1.6 0.7 5.0 2.7 1.3 0.8 2.8 1.8 2.3 1.7 0.7 0.8 2.7 3.0 6.2 32.2 1.0 0.8 0.9 1.2 0.2 1.8 1.8 0.9 2.5 2.3 16.1 2.8 0.5 0.8 1.9 30.1 0.9 0.8 56.9 3.1 1.5 0.9 13.1 3.2 0.2 29.3 2.9 2.1 0.9 0.2 0.3 0.2 0.6 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.1 45.2 0.7 0.0 0.0 0.1 0.1 0.0 0.0 46.4 0.3 9.8 0.1 0.1 0.0 3.1 0.5 0.1 0.0 0.0 0.0 0.0 0.0 21.3 0.2 46.9 0.1 0.3 11.0 12.0 1.4 0.3 0.1 25.5 0.1 29.8 0.0 0.0 0.4 0.1 0.1 0.2 0.1 0.3 0.2 10.8 0.1 0.1 0.3 0.1 0.1 36.0 38.2 57.8 0.0 13.5 0.1 2.9 4.9 2.0 18.9 9.4 17.4 22.7 15.8 20.1 23.9 15.5 8.6 12.1 0.5 6.1 5.7 22.2 22.2 12.1 0.6 0.7 0.7 1.2 0.7 0.8 1.0 0.8 0.9 0.8 0.9 0.9 0.7 3.2 4.9 0.3 42.6 2.3 0.2 0.4 1.2 6.7 0.7 1.0 0.9 0.0 0.6 0.0 12.5 0.2 42.6 0.1 0.0 0.0 0.0 0.3 0.2 1.6 0.0 5.5 0.7 0.2 0.3 1.5 2.0 0.3 15.8 0.4 1.1 1.1 2.6 1.7 1.0 0.1 0.0 8.8 27.8 0.2 0.0 11.6 3.6 1.9 10.3 11.5 15.5 1.0 0.5 0.0 0.0 0.0 30.4 0.3 0.0 0.2 0.0 77.9 0.0 1.0 0.4 0.7 6.4 0.6 1.0 0.1 43.6 0.3 0.3 0.1 MAP4K2 "BL44, GCK, RAB8IP" ENSG00000168067 "Mitogen-activated protein kinase kinase kinase kinase 2" Q12851 11 64784918-64803241 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Immunity, Innate immunity, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 46.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007330 Enhanced Approved Vesicles NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 32: U-937 - Innate immune response" "Cluster 58: T-cells - T-cell receptor" Vesicles "HPA007330: AB_1079361" "unprognostic (1.66e-1)" "unprognostic (2.83e-1)" "unprognostic (3.07e-3)" "unprognostic (4.37e-3)" "unprognostic (2.67e-1)" "unprognostic (9.23e-2)" "prognostic unfavorable (3.10e-5)" "unprognostic (4.51e-2)" "unprognostic (3.65e-1)" "unprognostic (5.28e-2)" "unprognostic (1.24e-2)" "unprognostic (1.41e-1)" "unprognostic (2.47e-2)" "unprognostic (2.97e-1)" "unprognostic (1.57e-2)" "unprognostic (1.82e-1)" "unprognostic (1.95e-2)" 5.0 3.9 8.9 6.9 7.2 15.5 4.1 9.8 9.9 4.6 4.9 5.6 3.3 4.8 2.5 2.7 3.8 4.2 4.3 7.6 7.0 5.4 2.0 9.7 17.6 7.8 8.0 3.4 5.0 3.2 5.8 8.9 8.1 4.7 3.0 5.3 6.6 5.8 2.5 3.5 8.9 3.7 6.6 18.0 5.2 4.6 9.7 7.4 7.0 1.5 14.2 4.6 3.5 8.8 9.4 8.4 5.4 9.8 4.7 2.9 12.7 7.0 6.5 8.2 5.8 3.7 4.3 16.4 12.6 8.0 14.5 2.8 6.5 6.8 4.9 21.5 3.1 28.9 12.0 7.9 5.8 15.3 10.4 2.9 3.4 6.4 4.1 5.7 20.3 28.0 2.5 1.5 2.5 11.8 9.2 15.2 3.6 5.6 11.2 18.8 0.6 18.9 4.6 4.7 6.4 9.3 6.0 7.8 6.4 6.1 15.5 23.2 15.8 6.8 15.0 6.3 2.9 1.8 3.8 18.1 6.0 22.8 5.1 2.2 4.3 5.9 4.9 12.5 4.9 9.9 6.5 4.4 4.4 6.6 7.7 6.0 8.0 2.5 15.8 5.0 9.5 7.3 8.9 7.2 9.8 9.9 7.6 7.0 7.8 8.0 8.1 6.6 9.7 8.8 21.6 3.2 4.8 6.8 32.9 1.3 2.8 1.8 6.2 20.6 8.1 10.4 4.7 7.2 2.4 1.8 25.0 7.6 9.4 6.8 3.9 1.7 33.8 2.6 3.8 20.0 6.0 5.0 5.9 1.7 11.3 4.9 9.2 6.0 1.3 7.7 24.3 2.0 11.0 11.8 4.6 1.8 6.1 8.9 3.1 46.8 4.1 16.2 1.8 18.7 13.4 7.2 14.4 2.0 7.2 0.9 16.2 7.2 15.6 1.8 1.6 3.6 1.5 14.6 6.6 3.7 4.3 2.1 13.8 5.2 1.4 5.1 19.9 22.6 2.2 2.0 MAP4K3 "GLK, MAPKKKK3, RAB8IPL1" ENSG00000011566 "Mitogen-activated protein kinase kinase kinase kinase 3" Q8IVH8 2 39249266-39437301 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 118.8;Excitatory neurons: 201.0;Inhibitory neurons: 198.3;Microglial cells: 144.3;Oligodendrocyte precursor cells: 160.4;Oligodendrocytes: 129.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "AF22: 102.3;RT4: 97.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030380 Approved Approved "Nucleoplasm,Centriolar satellite" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 44: Endometrium - Transcription" "Centriolar satellite" Nucleoplasm "HPA030380: AB_10601132" "unprognostic (4.82e-2)" "unprognostic (7.22e-2)" "unprognostic (5.87e-3)" "unprognostic (7.34e-3)" "unprognostic (6.77e-2)" "unprognostic (2.57e-1)" "unprognostic (1.05e-2)" "unprognostic (6.73e-2)" "unprognostic (1.66e-1)" "unprognostic (6.73e-2)" "unprognostic (4.33e-3)" "unprognostic (4.26e-2)" "unprognostic (2.12e-1)" "unprognostic (3.08e-2)" "unprognostic (3.30e-1)" "unprognostic (2.43e-1)" "unprognostic (5.08e-2)" 15.8 17.1 11.6 6.7 12.5 10.5 16.6 21.6 16.7 15.0 15.3 15.5 13.2 17.2 13.4 10.2 13.6 14.7 19.3 14.2 11.2 24.5 15.1 13.3 6.1 9.9 10.0 20.2 12.2 25.3 12.2 27.4 10.0 16.9 13.0 28.0 10.8 14.0 30.9 16.4 14.3 14.5 11.3 11.6 26.6 21.3 10.2 8.1 24.4 22.2 6.1 18.3 11.4 14.4 25.6 15.6 102.3 16.3 16.3 32.4 28.0 22.1 28.3 21.6 18.3 13.3 12.6 5.5 24.3 15.3 22.1 13.6 39.0 19.7 32.6 6.3 16.0 9.2 10.8 30.9 42.3 4.0 14.5 29.3 19.0 28.1 30.1 22.6 18.8 5.0 12.1 9.9 29.2 13.9 9.0 6.0 30.7 24.0 23.4 9.9 33.3 4.2 28.3 97.3 18.2 20.7 12.9 20.7 58.8 32.0 13.9 5.6 15.4 16.7 19.7 15.0 12.1 15.1 9.3 1.9 20.5 6.6 19.0 0.7 0.1 0.0 0.2 0.2 0.0 0.0 0.2 0.1 0.0 0.1 0.2 0.2 0.0 0.2 0.4 0.1 0.1 0.0 11.6 12.5 21.6 16.7 14.2 11.2 9.9 10.0 10.0 11.3 10.2 14.4 36.2 3.2 8.4 118.8 8.1 17.6 17.9 11.0 16.5 24.7 14.1 12.3 38.2 21.5 16.5 22.0 25.0 13.1 4.1 12.5 19.6 10.3 45.1 22.3 19.9 20.6 9.6 4.6 201.0 12.4 6.7 18.2 25.5 59.4 2.5 15.6 14.3 18.6 9.7 6.7 198.3 13.9 2.0 10.9 20.6 103.0 20.8 14.4 5.4 144.3 4.4 13.2 3.1 160.4 129.2 17.5 5.7 17.7 14.3 18.6 14.0 11.9 19.5 37.9 19.7 18.7 17.6 22.6 19.8 11.8 19.2 10.4 5.9 17.4 10.6 30.2 MAP4K4 "FLH21957, HGK, NIK" ENSG00000071054 "Mitogen-activated protein kinase kinase kinase kinase 4" O95819 2 101696850-101894689 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 5 "brain: 472.1" "Cell type enhanced" "Detected in many" "Microglial cells: 337.3;Oligodendrocytes: 1134.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008476 Uncertain NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 70: Brain - Nervous system development" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA008476: AB_1079362" "unprognostic (6.40e-2)" "unprognostic (1.09e-2)" "unprognostic (4.01e-1)" "unprognostic (1.89e-1)" "unprognostic (1.88e-1)" "unprognostic (1.87e-2)" "unprognostic (2.83e-2)" "prognostic unfavorable (1.57e-4)" "unprognostic (4.29e-2)" "unprognostic (9.79e-2)" "unprognostic (2.22e-3)" "unprognostic (8.65e-2)" "prognostic unfavorable (3.62e-6)" "unprognostic (6.67e-3)" "unprognostic (8.98e-2)" "unprognostic (3.15e-1)" "unprognostic (7.14e-3)" 54.1 9.1 272.6 42.9 316.1 72.5 32.2 208.8 252.5 23.9 95.0 21.1 10.6 27.4 12.1 35.2 19.7 34.5 44.8 219.4 256.3 15.0 32.8 29.2 54.1 317.5 286.1 23.1 16.1 15.0 10.0 49.4 273.1 13.9 17.8 22.7 19.3 10.2 37.4 21.1 17.7 28.7 246.7 24.2 22.0 40.1 348.5 44.3 15.8 30.6 60.1 33.1 25.6 472.1 112.7 83.8 175.2 84.3 162.4 288.6 219.5 139.8 114.3 122.2 100.1 139.5 145.6 163.1 118.3 210.3 36.0 45.5 56.0 123.2 121.1 219.8 38.0 122.4 62.5 367.7 136.7 59.1 5.5 261.3 55.3 301.9 133.5 122.1 322.5 90.3 80.9 0.4 325.4 61.3 137.8 36.5 89.2 42.5 131.5 164.1 120.0 0.6 81.2 38.8 68.5 113.6 96.5 0.4 104.0 160.8 22.4 105.1 409.1 240.5 102.9 70.6 168.6 0.3 0.4 96.7 155.2 73.2 180.1 8.8 3.2 0.0 2.3 3.2 1.6 3.4 2.9 1.5 1.1 5.0 2.2 2.5 13.5 1.1 3.1 6.0 3.7 1.5 272.6 316.1 208.8 252.5 219.4 256.3 317.5 286.1 273.1 246.7 348.5 472.1 104.3 19.2 23.9 283.0 64.5 30.0 41.9 17.4 12.5 109.1 14.3 17.4 71.0 28.6 29.6 18.4 50.1 13.1 38.4 12.0 0.0 57.4 31.5 67.2 77.1 84.2 17.4 48.0 197.5 53.2 23.4 49.7 26.5 101.0 24.0 151.8 67.1 39.2 38.8 35.3 122.4 13.6 14.2 26.9 245.9 46.0 55.0 54.7 19.6 337.3 88.0 49.2 10.3 228.7 1134.5 128.1 12.0 17.3 18.0 72.1 5.3 6.3 22.9 10.4 52.6 65.2 73.3 29.0 82.1 24.3 24.6 7.8 38.4 17.2 14.4 40.4 MAP4K5 "GCKR, KHS, KHS1" ENSG00000012983 "Mitogen-activated protein kinase kinase kinase kinase 5" Q9Y4K4 14 50418501-50561126 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocyte precursor cells: 332.7;Oligodendrocytes: 707.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "basophil: 66.7;eosinophil: 26.3" "Lineage enriched" "Detected in all" 7 "granulocytes: 66.7" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036696, HPA078030" Uncertain Approved "Plasma membrane,Cytosol" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 70: Brain - Nervous system development" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "Plasma membrane" "HPA036696: AB_10672362, HPA078030: " "unprognostic (1.39e-1)" "unprognostic (1.00e-1)" "unprognostic (3.80e-1)" "unprognostic (1.66e-1)" "unprognostic (4.41e-2)" "unprognostic (1.43e-1)" "unprognostic (8.58e-3)" "unprognostic (4.13e-2)" "unprognostic (6.31e-2)" "unprognostic (2.24e-2)" "unprognostic (1.53e-3)" "unprognostic (7.34e-2)" "unprognostic (1.78e-2)" "unprognostic (3.71e-2)" "unprognostic (1.40e-1)" "unprognostic (9.58e-3)" "unprognostic (2.02e-2)" 20.5 12.8 16.2 13.2 31.1 22.1 22.2 20.7 21.5 30.6 3.9 20.8 13.1 33.4 12.9 20.5 19.0 21.5 10.9 18.3 23.9 11.9 10.0 17.1 12.4 28.4 22.0 32.4 14.2 14.8 11.8 19.8 24.8 17.9 16.6 18.6 18.0 21.1 12.3 28.5 14.7 24.7 17.6 15.7 16.8 7.9 23.8 11.6 17.0 14.2 13.2 20.2 23.8 58.1 51.7 15.2 36.5 31.5 33.0 34.5 35.6 59.2 53.0 39.4 34.9 19.3 35.2 35.3 34.3 54.6 20.9 36.1 34.3 31.9 59.7 29.4 24.8 21.7 27.1 17.5 27.9 19.6 33.0 25.2 25.7 34.8 36.1 63.0 52.6 31.7 20.8 22.5 58.6 19.4 26.6 18.7 17.7 16.6 29.5 31.8 55.4 13.5 39.2 39.5 11.7 26.5 33.5 23.0 23.4 29.3 25.8 14.7 53.8 50.9 35.7 35.2 28.2 16.3 18.0 23.6 19.2 13.5 37.2 66.7 2.8 26.3 6.7 3.3 3.8 6.1 4.2 5.9 3.0 9.7 4.4 4.6 1.0 10.1 2.2 4.9 1.0 1.9 16.2 31.1 20.7 21.5 18.3 23.9 28.4 22.0 24.8 17.6 23.8 58.1 40.5 41.7 20.8 135.2 29.9 70.0 42.9 21.4 56.3 56.7 32.6 26.5 10.5 30.0 27.4 27.6 47.9 11.4 30.6 27.5 19.6 29.5 3.7 25.7 52.2 40.4 23.4 46.7 144.2 20.9 19.5 50.1 43.8 49.1 29.8 37.8 38.6 9.0 8.1 33.7 144.1 16.4 8.2 12.3 24.8 3.7 42.6 25.1 23.2 101.2 18.3 19.5 18.6 332.7 707.2 25.9 20.2 51.1 27.0 57.4 10.9 12.0 25.6 33.1 13.1 49.7 41.7 10.6 14.1 54.9 86.1 6.6 31.5 22.4 18.6 61.7 MAPK1 "ERK, ERK2, MAPK2, p41mapk, PRKM1, PRKM2" ENSG00000100030 "Mitogen-activated protein kinase 1" P28482 22 21759657-21867680 "Cancer-related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Cell cycle, Host-virus interaction, Transcription, Transcription regulation" "DNA-binding, Kinase, Repressor, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "K-562: 341.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003995, CAB004229, HPA005700, HPA030069, CAB079930, CAB079932, CAB079933" Enhanced Supported "Nuclear speckles,Cytosol" NA NA 140000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 65: Brain - Ion transport" "Cluster 1: K-562 - Erythropoiesis" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "Nuclear speckles" "CAB004229: AB_627547, CAB079930: , CAB079932: , CAB079933: , HPA003995: AB_1078751, HPA005700: AB_1078750, HPA030069: AB_10602035" "unprognostic (9.41e-3)" "unprognostic (2.68e-1)" "unprognostic (2.50e-3)" "unprognostic (4.17e-1)" "unprognostic (4.44e-3)" "unprognostic (1.72e-1)" "prognostic unfavorable (4.95e-4)" "unprognostic (2.29e-1)" "unprognostic (1.67e-1)" "unprognostic (1.58e-1)" "unprognostic (8.43e-3)" "unprognostic (1.04e-1)" "unprognostic (1.35e-2)" "unprognostic (2.08e-1)" "unprognostic (1.94e-1)" "unprognostic (1.41e-1)" "unprognostic (6.49e-2)" 31.1 33.1 64.8 35.9 84.4 41.2 29.8 37.3 80.9 31.4 32.9 36.1 25.8 29.6 30.1 43.0 29.0 28.9 42.2 91.3 46.4 42.1 34.2 38.5 36.8 29.1 45.1 29.2 38.1 51.7 12.0 33.1 35.9 32.8 36.2 30.3 28.9 32.7 38.1 45.0 29.5 39.1 43.8 40.5 33.9 43.7 60.1 44.4 46.1 41.9 41.9 35.5 18.9 43.2 78.7 48.0 60.5 37.2 75.9 76.7 25.9 84.7 77.5 73.2 72.0 43.8 40.8 45.8 41.3 112.7 67.5 74.6 73.9 67.9 97.8 180.4 72.1 78.9 43.0 67.7 73.5 113.2 80.5 56.9 60.1 89.4 81.6 58.0 101.7 45.4 341.9 50.5 97.5 36.6 72.0 38.5 24.4 104.5 46.8 79.4 149.6 13.2 55.5 62.9 50.0 28.6 91.5 64.2 57.2 60.4 42.4 47.1 90.1 61.5 79.6 71.9 54.2 47.1 59.4 65.8 60.0 60.0 68.4 1.4 4.9 7.2 15.9 6.0 4.9 2.3 3.6 6.0 4.1 2.6 3.5 6.1 16.5 9.3 6.9 4.0 3.4 4.0 64.8 84.4 37.3 80.9 91.3 46.4 29.1 45.1 35.9 43.8 60.1 43.2 36.8 48.1 35.8 97.6 44.0 60.2 28.4 25.1 28.5 25.5 32.5 24.5 41.5 42.9 31.2 51.5 54.2 21.8 151.7 74.4 19.6 28.5 49.0 33.5 40.3 39.9 59.6 63.8 109.2 39.2 23.2 38.4 52.0 45.0 92.8 28.8 52.1 63.5 53.2 28.6 91.2 42.2 26.4 89.0 77.1 14.7 32.6 74.9 40.9 68.4 75.0 35.8 143.2 82.4 75.1 45.3 35.2 44.4 37.0 43.8 32.8 46.0 32.2 22.4 32.9 44.6 37.3 74.1 53.4 44.9 61.8 19.2 91.4 43.3 38.6 38.8 MAPK10 "JNK3, p493F12, p54bSAPK, PRKM10" ENSG00000109339 "Mitogen-activated protein kinase 10" P53779 4 85990007-86594625 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Biological rhythms" "Kinase, Serine/threonine-protein kinase, Transferase" "Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 91.3" "Cell type enhanced" "Detected in many" "Astrocytes: 902.0;Excitatory neurons: 1018.9;Inhibitory neurons: 727.8;Late spermatids: 400.5;Oligodendrocyte precursor cells: 596.6;Oligodendrocytes: 302.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in many" 6 "AF22: 155.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB022625 Approved NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 10: Brain - Neuronal signaling" "Cluster 12: NES - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "CAB022625: " "unprognostic (2.46e-2)" "unprognostic (4.36e-2)" "unprognostic (1.13e-1)" "unprognostic (4.05e-2)" "unprognostic (5.17e-2)" "unprognostic (2.03e-1)" "unprognostic (4.59e-2)" "unprognostic (4.82e-2)" "unprognostic (3.81e-2)" "unprognostic (4.45e-2)" "unprognostic (1.18e-3)" "unprognostic (3.02e-2)" "prognostic favorable (3.11e-4)" "unprognostic (1.92e-2)" "unprognostic (1.44e-1)" "unprognostic (6.22e-3)" "prognostic favorable (5.57e-4)" 26.1 15.6 45.2 5.1 61.6 14.5 7.4 25.4 91.3 17.5 23.5 5.7 3.6 14.5 18.8 9.8 15.8 13.8 6.9 60.4 24.9 20.4 3.2 8.6 5.2 29.0 36.2 14.7 7.4 10.3 25.5 4.3 31.4 22.4 5.4 18.3 4.7 24.2 2.6 4.6 5.1 15.5 24.9 7.4 6.6 26.4 39.2 3.4 20.5 4.2 4.6 14.0 18.4 55.6 2.9 4.9 155.0 4.8 4.1 3.6 5.6 3.2 2.9 2.7 1.2 3.3 4.4 7.1 5.1 1.9 3.8 9.4 1.8 4.2 4.3 4.9 4.0 5.7 7.3 4.6 3.6 2.7 3.1 4.1 1.9 3.7 5.0 5.5 3.5 4.8 5.2 27.9 1.7 3.5 4.4 3.1 8.8 0.7 3.2 4.9 4.0 2.5 10.7 16.9 9.2 8.4 3.3 5.9 2.2 5.0 8.8 3.3 7.5 6.3 6.4 3.0 2.7 8.2 5.1 4.4 9.9 3.5 3.8 3.3 0.7 1.2 0.8 0.7 1.0 1.3 0.7 1.0 0.6 1.1 1.0 1.4 4.4 1.2 0.7 1.2 1.2 0.9 45.2 61.6 25.4 91.3 60.4 24.9 29.0 36.2 31.4 24.9 39.2 55.6 4.3 22.4 33.8 902.0 1.6 0.8 15.7 5.5 4.0 26.1 3.2 3.7 1.6 8.6 12.8 22.0 6.2 0.3 0.1 0.0 11.7 2.4 219.5 61.1 25.1 1.3 2.4 0.0 1018.9 0.0 0.5 16.9 2.0 7.1 2.5 6.2 1.1 0.0 0.3 38.7 727.8 0.0 4.1 0.3 0.0 400.5 26.4 1.5 1.8 185.5 0.0 15.7 0.0 596.6 302.8 2.0 0.0 54.9 0.1 7.6 0.0 22.6 68.9 10.8 6.6 7.2 18.5 10.5 5.5 1.3 1.0 0.1 0.9 28.5 0.0 22.6 MAPK11 "p38-2, p38Beta, PRKM11, SAPK2" ENSG00000185386 "Mitogen-activated protein kinase 11" Q15759 22 50263713-50270767 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 70.9" "Cell type enhanced" "Detected in many" "Adipocytes: 29.5;Astrocytes: 16.6;Endothelial cells: 21.1;Excitatory neurons: 15.8;Hepatic stellate cells: 20.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB012961, HPA045069" Approved Approved Mitochondria NA NA "Cluster 57: Non-specific - Angiogenesis" "Cluster 17: WM-115 - Nervous system development" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Mitochondria "CAB012961: AB_2533144, HPA045069: AB_2679207" "unprognostic (1.11e-1)" "unprognostic (1.28e-1)" "unprognostic (1.49e-2)" "unprognostic (1.92e-1)" "unprognostic (1.18e-2)" "unprognostic (1.64e-3)" "unprognostic (1.02e-1)" "unprognostic (5.84e-2)" "unprognostic (5.89e-2)" "unprognostic (2.46e-1)" "unprognostic (4.96e-3)" "unprognostic (2.18e-1)" "prognostic unfavorable (6.02e-6)" "unprognostic (9.84e-2)" "unprognostic (4.25e-2)" "unprognostic (9.16e-2)" "unprognostic (2.10e-2)" 27.5 6.8 52.3 7.9 56.0 1.1 24.0 48.2 70.9 15.1 40.6 7.3 1.9 15.5 5.8 9.4 16.7 8.7 18.9 55.2 49.6 18.6 4.8 16.8 9.4 48.2 47.2 12.5 5.7 5.4 28.4 8.3 48.2 18.2 2.6 8.6 7.2 7.2 6.4 7.5 8.3 9.4 47.4 16.3 10.9 6.1 50.2 3.5 11.0 5.8 6.1 11.6 12.3 51.0 2.8 6.8 7.4 27.8 9.5 14.3 0.2 10.2 7.4 6.8 2.7 2.8 5.2 0.0 8.7 9.9 11.3 6.9 4.9 4.2 0.5 13.9 3.4 10.1 10.4 0.6 10.9 2.5 15.0 19.9 12.3 1.9 0.8 7.7 15.2 10.6 8.1 26.8 6.9 12.4 0.5 9.4 0.6 8.4 7.7 26.7 0.1 9.9 10.3 0.0 6.8 18.4 9.0 3.7 7.7 0.9 12.2 7.9 24.0 20.4 16.5 1.5 3.7 1.2 3.2 11.8 10.4 2.9 17.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 52.3 56.0 48.2 70.9 55.2 49.6 48.2 47.2 48.2 47.4 50.2 51.0 29.5 0.0 1.1 16.6 2.2 1.9 1.8 3.2 8.0 3.3 1.1 1.5 6.6 1.5 1.7 0.0 6.2 0.0 1.8 0.1 1.9 1.0 4.7 0.6 1.8 21.1 0.0 0.4 15.8 0.2 0.4 2.7 0.5 1.7 0.0 0.1 20.0 2.1 0.3 0.0 3.6 0.2 2.0 1.3 2.1 9.7 3.1 0.5 5.4 13.1 0.1 5.9 0.0 1.0 0.9 0.7 0.0 2.2 1.6 2.9 0.0 1.9 1.3 11.4 0.0 0.6 1.8 1.3 3.2 1.8 1.3 0.0 3.3 0.7 0.1 1.1 MAPK12 "ERK6, p38gamma, PRKM12, SAPK-3, SAPK3" ENSG00000188130 "Mitogen-activated protein kinase 12" P53778 22 50245450-50261716 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 8 "skeletal muscle: 279.7;tongue: 120.9" "Cell type enhanced" "Detected in many" "Adipocytes: 23.1;Astrocytes: 22.9;Endothelial cells: 15.8;Hepatic stellate cells: 20.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Region enhanced" "Detected in all" "cerebellum: 31.6" "Low region specificity" "Detected in all" "CAB025483, HPA054562" Enhanced Approved "Nuclear speckles,Cytosol" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 25: RPMI-8226 - Immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Nuclear speckles" Cytosol "CAB025483: , HPA054562: AB_2682524" "unprognostic (3.68e-2)" "unprognostic (1.72e-1)" "unprognostic (4.53e-3)" "unprognostic (1.54e-1)" "unprognostic (3.22e-2)" "unprognostic (6.35e-3)" "unprognostic (3.90e-3)" "unprognostic (3.16e-2)" "unprognostic (6.02e-2)" "unprognostic (5.70e-2)" "unprognostic (3.48e-2)" "unprognostic (1.07e-1)" "prognostic unfavorable (5.00e-6)" "unprognostic (2.57e-1)" "unprognostic (8.88e-2)" "unprognostic (1.11e-2)" "unprognostic (4.28e-3)" 11.0 2.3 15.6 3.8 16.5 1.3 7.9 15.5 21.2 11.4 9.2 4.7 3.5 19.0 9.8 6.3 11.2 4.4 15.7 15.1 16.5 10.7 1.4 6.8 4.1 17.1 14.9 10.6 1.8 4.3 25.1 4.1 14.6 10.0 1.1 1.4 4.3 6.9 279.7 1.5 4.4 8.6 14.6 4.3 5.0 4.6 15.2 0.9 3.2 120.9 1.4 6.0 5.9 13.9 23.2 13.9 5.3 16.3 12.4 13.5 7.5 17.5 15.1 28.2 18.3 19.6 7.2 45.1 23.4 19.6 16.8 15.4 24.3 3.4 5.5 12.8 34.0 29.2 46.7 24.9 37.7 28.4 54.5 29.8 6.0 7.2 0.0 16.8 33.2 4.0 26.3 38.5 13.4 12.8 0.0 35.4 15.9 7.6 22.5 41.4 14.2 43.9 17.5 3.0 18.0 6.5 13.3 0.5 22.1 4.2 7.1 29.6 18.7 28.5 26.1 6.6 11.2 9.3 7.3 24.5 7.2 24.7 11.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 15.6 16.5 15.5 21.2 15.1 16.5 17.1 14.9 14.6 14.6 15.2 13.9 23.1 0.0 3.2 22.9 1.6 0.8 0.7 3.3 1.2 5.5 1.2 1.3 8.8 4.3 0.8 0.0 0.0 0.3 0.9 0.3 1.9 0.5 0.3 0.6 10.0 15.8 1.8 1.7 9.8 0.0 2.8 5.3 2.6 0.7 10.8 0.6 20.7 0.9 6.3 1.7 6.5 0.2 8.2 2.2 0.8 1.9 6.5 2.2 0.0 6.5 0.6 8.1 0.0 5.0 0.9 0.5 0.0 3.8 2.8 3.6 0.4 8.0 0.9 2.2 6.6 3.3 3.0 0.7 12.1 0.8 0.6 0.4 2.2 3.2 0.3 0.2 MAPK13 "p38delta, PRKM13, SAPK4" ENSG00000156711 "Mitogen-activated protein kinase 13" O15264 6 36127809-36144524 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 102.4" "Cell type enhanced" "Detected in many" "Distal enterocytes: 146.2;Late spermatids: 282.5;Proximal enterocytes: 178.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HBEC3-KT: 63.8;RPMI-8226: 40.2;RT4: 47.0" "Low region specificity" "Detected in single" "Region enriched" "Detected in all" 14 "cerebellum: 37.5" "HPA007667, CAB025854" Enhanced Approved "Nucleoplasm,Nucleoli,Nucleoli rim,Cytosol" NA NA "Cluster 35: T-regs - Unknown function" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 30: Mammary glandular cells - Lactation" "Nucleoplasm, Nucleoli, Nucleoli rim, Cytosol" "CAB025854: , HPA007667: AB_1079867" "unprognostic (6.36e-2)" "unprognostic (6.88e-2)" "unprognostic (2.93e-1)" "unprognostic (6.64e-3)" "unprognostic (1.13e-2)" "unprognostic (4.80e-2)" "unprognostic (4.30e-3)" "unprognostic (5.28e-2)" "unprognostic (1.77e-1)" "unprognostic (2.14e-2)" "unprognostic (1.57e-1)" "unprognostic (7.21e-2)" "prognostic favorable (9.00e-4)" "unprognostic (3.12e-2)" "unprognostic (1.70e-1)" "unprognostic (2.21e-2)" "unprognostic (1.41e-1)" 8.7 55.9 3.1 8.8 3.0 9.4 14.2 0.5 4.4 18.6 0.0 44.6 30.9 3.4 11.5 102.4 7.6 7.5 2.5 2.9 2.2 17.3 6.7 23.8 7.9 0.6 0.0 5.4 47.7 38.9 33.3 5.6 0.2 16.7 24.4 2.7 49.5 15.5 1.2 74.1 40.1 1.9 0.1 16.1 24.1 40.0 4.2 6.9 18.9 1.0 12.4 12.2 39.3 2.7 31.4 0.3 0.7 0.5 2.4 11.2 4.3 3.3 0.4 0.3 0.8 22.3 28.4 7.0 2.0 2.5 4.6 24.4 0.3 63.8 0.7 20.0 7.9 0.2 1.2 22.8 4.0 0.4 2.2 9.2 25.9 4.3 1.0 4.5 4.1 1.2 0.6 9.4 0.9 12.7 0.4 2.6 0.4 30.9 0.4 21.0 0.5 40.2 11.6 47.0 30.5 0.7 2.5 0.5 0.2 1.3 33.0 4.1 6.3 2.4 0.4 1.0 0.7 0.8 12.7 2.3 0.1 1.3 0.2 7.6 0.4 6.5 18.3 0.1 12.3 13.9 14.5 15.4 0.1 22.0 12.8 14.4 4.6 3.8 0.1 0.2 38.0 8.6 3.1 3.0 0.5 4.4 2.9 2.2 0.6 0.0 0.2 0.1 4.2 2.7 1.5 28.9 33.0 1.0 16.4 27.3 43.5 24.9 15.4 0.7 58.8 17.7 1.7 25.8 27.3 29.5 6.2 55.3 14.9 146.2 15.6 56.9 110.3 9.1 2.8 2.1 65.5 0.0 10.0 115.9 11.8 5.0 32.1 26.2 2.5 21.1 1.1 1.7 40.3 0.0 6.7 83.2 34.6 6.8 3.3 282.5 7.2 8.8 17.8 3.7 14.2 2.1 21.6 1.5 1.2 103.6 102.2 9.8 11.4 37.1 178.4 11.5 3.7 2.4 0.0 2.2 3.4 56.6 2.9 62.6 53.3 32.3 18.5 2.5 93.0 59.9 MAPK14 "CSBP1, CSBP2, CSPB1, Mxi2, p38, PRKM14, PRKM15" ENSG00000112062 "Mitogen-activated protein kinase 14" Q16539 6 36027677-36111236 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 104.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "basophil: 79.0;neutrophil: 24.9" "Lineage enriched" "Detected in all" 7 "granulocytes: 79.0" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010285, CAB040578, HPA051825" Approved Supported "Nuclear speckles,Cytosol" NA NA 970000 "Cluster 38: Basophils - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 32: U-937 - Innate immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "Nuclear speckles" Cytosol "CAB010285: AB_632140, CAB040578: , HPA051825: " "unprognostic (6.76e-3)" "unprognostic (6.28e-2)" "unprognostic (6.30e-3)" "unprognostic (3.30e-3)" "unprognostic (6.98e-2)" "unprognostic (4.04e-2)" "unprognostic (8.10e-2)" "unprognostic (1.93e-1)" "unprognostic (2.20e-3)" "unprognostic (8.39e-2)" "unprognostic (6.27e-2)" "unprognostic (1.10e-1)" "unprognostic (1.47e-2)" "unprognostic (3.66e-3)" "unprognostic (6.66e-2)" "unprognostic (3.25e-1)" "unprognostic (1.58e-1)" 29.9 26.1 15.2 31.5 16.5 89.3 23.8 19.2 17.1 30.8 19.3 26.6 27.9 37.2 15.8 32.3 25.7 23.5 25.7 17.2 18.2 23.9 41.4 28.3 28.0 11.5 11.7 22.2 18.3 20.6 19.3 44.6 12.1 19.6 29.0 14.8 21.0 24.4 33.5 34.4 26.2 39.0 13.0 44.9 22.5 9.1 18.1 38.6 31.1 31.9 33.3 32.3 29.2 13.8 49.7 26.7 28.3 44.9 60.0 59.8 62.2 50.2 64.8 58.7 60.3 67.3 24.8 40.4 49.6 54.9 28.0 34.8 47.2 43.7 60.9 47.3 37.6 94.9 37.2 53.1 33.2 60.3 54.9 43.1 40.5 42.2 40.9 47.6 67.1 67.2 52.4 49.1 40.3 21.1 62.2 62.5 17.0 29.9 26.2 71.7 45.5 37.5 38.5 67.6 21.8 17.2 46.0 33.5 50.3 34.1 40.8 99.9 47.9 52.5 29.8 33.6 47.7 24.3 59.8 39.5 23.2 112.1 43.9 79.0 10.3 6.3 4.5 7.2 5.5 3.1 4.4 5.1 8.2 5.3 4.6 4.7 24.9 6.1 10.8 4.0 5.8 5.1 15.2 16.5 19.2 17.1 17.2 18.2 11.5 11.7 12.1 13.0 18.1 13.8 24.4 32.1 13.9 37.2 22.6 15.9 11.0 13.9 28.5 18.9 14.0 11.7 25.0 14.3 18.5 18.4 31.3 45.4 26.8 29.0 1.9 13.9 3.6 18.7 25.8 22.6 16.8 47.1 104.9 11.3 18.7 25.9 21.9 30.7 21.0 17.7 28.9 52.9 25.3 11.8 79.2 25.4 10.2 51.7 24.9 5.2 24.5 38.5 10.6 52.5 58.7 10.9 39.1 46.8 69.6 22.8 16.2 26.7 27.7 10.3 33.7 17.2 20.9 22.5 13.1 20.4 15.7 9.9 8.5 27.1 19.0 23.9 28.0 12.3 18.8 10.7 MAPK15 "ERK7, ERK8" ENSG00000181085 "Mitogen-activated protein kinase 15" Q8TD08 8 143716340-143722458 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 54.9;fallopian tube: 46.7" "Group enriched" "Detected in some" 5 "Endometrial ciliated cells: 62.5;Respiratory ciliated cells: 107.9" "Cancer enhanced" "Detected in many" "ovarian cancer: 18.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CAPAN-2: 9.6;HeLa: 20.7;MCF7: 14.3;T-47d: 14.0" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" HPA002704 Approved "Nucleoplasm,Cell Junctions,Cytosol" NA NA "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 20: HeLa - Mitochondria" "Cluster 49: Ciliated cells - Cilium organization" "Nucleoplasm, Cytosol" "Cell Junctions" "HPA002704: AB_1079307" "unprognostic (9.11e-2)" "unprognostic (1.38e-1)" "unprognostic (8.04e-3)" "unprognostic (2.94e-1)" "unprognostic (2.54e-2)" "unprognostic (1.14e-2)" "unprognostic (1.22e-1)" "unprognostic (6.09e-2)" "unprognostic (2.59e-2)" "unprognostic (1.48e-1)" "unprognostic (3.88e-1)" "unprognostic (9.51e-2)" "unprognostic (2.64e-2)" "unprognostic (1.54e-2)" "unprognostic (5.78e-1)" "unprognostic (6.35e-2)" "unprognostic (1.62e-2)" 1.6 0.1 3.3 0.2 4.0 0.0 1.9 1.7 8.1 6.9 54.9 1.0 0.3 2.5 2.4 1.1 46.7 0.2 0.6 5.0 3.6 10.5 0.3 12.1 0.4 10.2 14.5 0.9 4.4 9.4 6.9 0.3 7.0 2.2 0.2 0.0 2.2 1.7 0.1 4.0 0.8 0.4 6.6 0.7 0.8 11.4 6.4 1.1 16.1 0.0 0.2 0.5 2.1 3.0 0.4 0.6 1.9 0.0 0.0 0.0 0.7 1.8 0.0 0.0 0.0 0.5 9.6 0.0 1.6 0.0 0.0 5.5 0.1 0.2 0.0 1.0 2.0 0.0 20.7 0.0 0.2 0.0 0.1 0.1 0.0 0.0 0.0 1.2 0.0 0.2 3.4 0.0 0.0 14.3 0.0 0.0 2.5 1.2 1.2 0.0 3.7 0.5 1.0 1.6 3.6 5.1 0.0 3.3 0.0 0.2 14.0 0.0 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 4.0 1.7 8.1 5.0 3.6 10.2 14.5 7.0 6.6 6.4 3.0 0.1 0.0 6.4 0.0 0.1 0.4 0.3 5.7 0.0 0.0 1.0 1.3 0.7 0.0 11.8 0.0 0.0 0.0 0.0 0.1 0.0 1.1 13.8 62.5 0.5 0.3 0.0 0.0 0.2 0.0 0.7 0.8 0.0 1.7 0.0 0.6 0.0 0.0 0.1 0.0 0.0 0.6 16.2 0.0 0.0 11.5 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.3 0.0 1.4 107.9 0.0 0.0 0.4 2.2 2.3 0.9 0.0 0.3 0.1 0.2 0.1 0.3 0.1 MAPK3 "ERK1, p44erk1, p44mapk, PRKM3" ENSG00000102882 "Mitogen-activated protein kinase 3" P27361 16 30114105-30123506 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Cell cycle, Host-virus interaction" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 336.9;Early spermatids: 267.2;Proximal enterocytes: 235.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "eosinophil: 49.1;neutrophil: 21.5" "Lineage enriched" "Detected in all" 7 "granulocytes: 49.1" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002683, HPA003995, HPA005700, HPA030069" Approved Supported Nucleoplasm NA NA 46000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 57: Non-specific - Angiogenesis" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "CAB002683: , HPA003995: AB_1078751, HPA005700: AB_1078750, HPA030069: AB_10602035" "unprognostic (5.03e-2)" "unprognostic (4.62e-2)" "unprognostic (3.46e-2)" "unprognostic (1.60e-1)" "unprognostic (4.70e-3)" "unprognostic (2.75e-1)" "prognostic unfavorable (1.11e-4)" "unprognostic (2.09e-2)" "unprognostic (3.59e-2)" "unprognostic (1.12e-1)" "unprognostic (1.55e-1)" "unprognostic (3.51e-2)" "unprognostic (8.78e-2)" "unprognostic (1.45e-1)" "unprognostic (3.01e-2)" "unprognostic (2.38e-1)" "unprognostic (1.19e-2)" 99.5 64.3 178.7 42.4 162.3 45.2 86.3 113.0 200.9 93.3 86.0 117.2 103.1 74.9 27.4 129.6 71.6 65.3 65.4 168.6 132.7 49.4 21.2 71.3 37.8 135.6 148.7 78.7 33.7 61.2 55.8 70.2 142.3 49.2 91.9 71.5 61.0 43.3 51.7 77.6 113.2 58.7 127.4 57.4 86.4 31.6 129.5 31.4 58.0 57.0 49.3 64.8 89.0 130.9 56.3 30.0 62.2 35.7 153.7 202.4 35.1 40.7 101.1 63.4 75.3 36.4 110.0 56.3 39.7 115.5 73.2 20.6 53.3 47.8 61.0 106.9 61.8 17.3 31.6 61.8 154.2 13.0 46.2 125.8 27.3 72.5 32.2 96.1 163.7 60.3 24.3 70.0 85.2 147.1 59.2 21.5 16.9 113.6 26.1 68.9 37.3 127.4 58.0 35.0 55.2 39.3 23.2 81.8 24.1 50.5 53.5 30.7 117.2 41.7 35.4 48.4 14.5 79.1 39.3 29.6 83.3 27.1 30.0 6.2 5.1 49.1 1.6 3.7 2.6 2.3 3.7 3.0 2.8 2.5 2.6 2.9 21.5 2.2 2.0 2.8 6.6 2.8 178.7 162.3 113.0 200.9 168.6 132.7 135.6 148.7 142.3 127.4 129.5 130.9 95.5 22.4 17.5 7.5 10.7 9.8 22.2 11.4 5.7 30.4 23.3 19.9 15.4 20.0 13.0 9.2 22.9 77.6 15.2 336.9 23.5 39.8 267.2 24.8 25.1 68.1 54.7 6.1 7.7 61.2 134.2 34.7 79.0 15.7 2.5 19.1 71.7 7.0 45.2 8.4 10.3 159.3 22.4 26.4 12.3 176.0 32.3 20.6 23.2 7.5 24.5 67.0 13.4 7.1 9.8 118.8 167.2 27.4 6.2 13.5 235.6 23.9 24.7 41.5 19.7 18.8 29.3 10.9 19.8 15.8 13.2 33.8 14.5 40.0 94.9 22.4 MAPK4 "Erk3-related, Erk4, PRKM4" ENSG00000141639 "Mitogen-activated protein kinase 4" P31152 18 50560087-50731826 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 81.9;parathyroid gland: 51.0" "Cell type enhanced" "Detected in some" "Astrocytes: 202.7;Excitatory neurons: 105.2;Inhibitory neurons: 58.5;Late spermatids: 66.4;Muller glia cells: 62.6" "Cancer enriched" "Detected in many" 4 "glioma: 15.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HAP1: 2.3;HeLa: 3.3;NTERA-2: 2.2;SCLC-21H: 11.6;SH-SY5Y: 2.8;SK-MEL-30: 1.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007461 Approved "Nucleoplasm,Golgi apparatus,Midbody" Yes NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoplasm, Golgi apparatus" Midbody "HPA007461: AB_1079308" "unprognostic (4.12e-2)" "unprognostic (3.24e-2)" "unprognostic (3.60e-1)" "unprognostic (1.42e-3)" "unprognostic (5.17e-2)" "unprognostic (1.84e-2)" "unprognostic (6.32e-2)" "unprognostic (2.08e-2)" "unprognostic (8.24e-2)" "unprognostic (1.61e-1)" "unprognostic (4.38e-3)" "unprognostic (2.16e-1)" "unprognostic (3.44e-7)" "unprognostic (1.96e-4)" "unprognostic (5.99e-4)" "unprognostic (2.31e-2)" "unprognostic (1.82e-1)" 0.9 26.8 56.5 0.2 79.9 0.0 0.8 56.4 46.0 1.5 28.0 6.8 0.6 0.8 3.1 2.3 1.5 1.8 22.1 41.6 57.5 3.3 4.5 2.3 0.0 65.4 70.0 2.9 1.4 51.0 17.8 2.6 56.7 5.0 0.8 22.6 0.9 9.8 1.5 1.3 1.6 1.8 48.8 0.1 2.1 2.4 81.9 7.3 6.2 1.5 0.0 4.6 1.3 38.7 0.0 0.0 1.0 0.6 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.0 0.0 0.0 1.1 1.1 3.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.7 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 11.6 2.8 0.0 0.8 1.9 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 56.5 79.9 56.4 46.0 41.6 57.5 65.4 70.0 56.7 48.8 81.9 38.7 0.4 9.6 0.0 202.7 0.0 0.0 0.4 0.0 0.0 11.4 0.9 1.1 22.9 1.5 0.0 0.0 0.0 4.6 0.0 0.0 5.9 0.9 30.1 0.0 0.0 0.3 0.0 0.0 105.2 0.0 0.3 1.0 0.0 0.0 0.0 0.7 0.0 1.0 0.4 5.0 58.5 0.0 0.0 0.0 0.0 66.4 0.9 0.1 0.0 7.5 0.0 62.6 0.0 18.6 1.9 0.4 0.0 1.5 0.0 0.7 0.0 0.2 0.0 1.0 0.0 1.0 0.7 0.8 0.6 0.0 0.0 1.8 0.0 0.4 0.0 0.1 MAPK6 "ERK3, HsT17250, p97MAPK, PRKM6" ENSG00000069956 "Mitogen-activated protein kinase 6" Q16659 15 51952106-52067375 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 218.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005184, HPA030262, HPA047825" Approved Supported Supported Cytosol NA NA "Cluster 15: NK-cells - Transcription" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 30: Epithelial cell lines - Translation" "Cluster 44: Endometrium - Transcription" Cytosol "CAB005184: AB_2140298, HPA030262: AB_10601868, HPA047825: " "unprognostic (6.61e-2)" "unprognostic (1.75e-2)" "unprognostic (5.05e-2)" "unprognostic (3.40e-3)" "unprognostic (2.72e-1)" "unprognostic (5.52e-2)" "unprognostic (6.13e-2)" "unprognostic (2.32e-3)" "unprognostic (3.99e-2)" "unprognostic (8.54e-2)" "unprognostic (3.68e-2)" "unprognostic (3.90e-2)" "unprognostic (3.27e-3)" "unprognostic (2.03e-1)" "unprognostic (1.72e-1)" "unprognostic (3.07e-2)" "unprognostic (2.31e-2)" 10.9 7.0 8.6 12.1 11.1 32.4 13.9 14.5 13.3 15.3 7.6 20.3 17.5 16.4 10.9 28.0 8.2 17.5 7.7 10.5 10.5 15.2 35.3 8.8 10.8 10.5 10.8 6.2 8.3 11.0 8.0 12.6 10.6 10.1 18.7 17.9 15.3 8.7 27.7 23.1 24.5 13.7 9.7 8.3 16.9 29.3 10.6 14.5 13.9 32.9 13.6 27.3 21.3 12.0 27.1 36.0 69.1 26.7 21.1 34.3 50.5 38.0 38.0 34.2 40.1 43.3 15.9 38.9 26.0 48.9 50.0 37.5 53.8 72.4 46.5 24.0 16.8 58.0 20.3 68.9 50.4 43.9 118.6 36.8 130.0 41.5 106.8 36.4 32.7 26.1 76.5 64.3 44.2 61.3 30.8 34.4 24.7 33.6 17.2 26.8 44.5 62.3 32.8 112.3 33.8 31.9 30.7 24.6 56.5 94.9 22.6 64.3 32.9 40.7 43.9 26.8 51.4 33.2 104.4 47.5 50.4 62.9 51.2 1.7 2.5 0.7 1.9 2.3 2.3 2.5 2.8 2.2 2.3 1.3 2.6 1.9 0.3 3.6 1.5 1.0 4.3 1.9 8.6 11.1 14.5 13.3 10.5 10.5 10.5 10.8 10.6 9.7 10.6 12.0 31.3 28.9 31.5 24.5 24.2 111.9 123.8 50.6 24.5 55.6 39.3 19.3 21.9 25.8 43.1 16.5 16.7 16.9 15.9 110.2 17.6 35.2 147.5 61.3 75.7 28.8 31.0 17.1 29.1 50.1 39.5 39.2 35.7 126.4 137.9 19.3 17.9 59.6 28.0 33.7 31.0 42.9 42.7 41.8 66.6 218.1 22.7 50.5 30.2 17.8 15.7 32.3 11.3 28.6 63.7 69.1 46.5 23.7 35.3 89.0 110.6 60.3 42.9 23.8 19.7 24.7 33.9 72.7 81.0 49.6 110.7 33.1 23.0 13.9 28.6 174.0 MAPK7 "BMK1, ERK5, PRKM7" ENSG00000166484 "Mitogen-activated protein kinase 7" Q13164 17 19377721-19383544 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Differentiation" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Spermatocytes: 33.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "ASC diff: 43.1;SuSa: 53.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB018561, HPA031031" Uncertain Enhanced Nucleoplasm,Cytosol NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 71: Testis - DNA repair" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 41: Macrophages - Immune response" Nucleoplasm Cytosol "CAB018561: AB_2140544, HPA031031: AB_2673706" "unprognostic (1.63e-1)" "unprognostic (2.75e-2)" "unprognostic (1.72e-1)" "unprognostic (2.90e-2)" "unprognostic (4.38e-2)" "unprognostic (1.20e-3)" "prognostic unfavorable (1.86e-4)" "unprognostic (5.67e-3)" "unprognostic (1.62e-2)" "unprognostic (1.16e-1)" "unprognostic (1.83e-2)" "unprognostic (4.75e-2)" "unprognostic (1.23e-2)" "unprognostic (1.90e-1)" "unprognostic (5.71e-1)" "unprognostic (1.55e-1)" "unprognostic (3.78e-2)" 8.3 13.7 4.0 4.0 4.4 5.2 7.7 4.0 5.9 14.3 4.4 10.6 5.5 11.1 3.3 16.3 8.7 4.5 6.2 3.9 4.5 7.7 3.9 8.7 3.7 5.3 6.1 12.5 3.4 2.9 6.1 6.7 4.4 8.9 3.5 2.2 6.7 6.1 5.0 12.5 7.3 6.7 3.3 9.4 6.7 11.8 5.0 3.5 7.4 3.4 3.6 10.1 15.2 4.1 6.9 11.0 9.9 7.7 43.1 17.2 10.4 9.0 8.3 13.0 12.4 12.2 1.4 4.1 7.3 16.5 10.4 8.2 10.4 9.4 7.8 7.2 8.3 1.9 8.4 5.4 21.2 1.9 7.8 21.6 6.2 18.2 7.2 12.0 9.5 7.5 3.7 1.4 13.2 4.8 13.0 7.4 10.7 8.4 6.7 8.6 12.9 3.0 5.4 3.7 4.4 12.3 9.7 1.0 5.0 53.7 6.1 3.1 6.0 14.6 10.8 15.5 6.7 2.6 4.0 1.2 16.5 1.6 9.2 0.8 3.4 10.7 3.7 6.5 2.0 1.8 1.8 3.2 2.3 1.0 1.6 2.0 1.1 4.9 6.0 1.4 1.0 3.1 4.0 4.4 4.0 5.9 3.9 4.5 5.3 6.1 4.4 3.3 5.0 4.1 10.7 6.4 3.3 2.6 7.8 5.5 6.1 9.5 13.6 2.4 5.8 4.6 5.3 2.8 5.6 5.5 2.1 5.7 6.7 16.2 5.9 8.1 8.7 3.0 7.9 8.5 10.7 1.7 2.0 6.2 8.0 9.6 12.2 5.2 2.5 7.7 7.5 1.1 7.7 0.0 2.1 6.9 10.2 6.9 6.1 5.7 11.5 14.4 3.6 6.5 3.4 13.1 17.5 1.0 2.0 8.0 20.8 11.7 9.3 6.3 9.0 3.5 3.2 2.1 26.3 8.4 11.1 33.2 16.4 9.8 4.3 5.1 6.2 7.7 6.7 5.3 MAPK8 "JNK, JNK1, PRKM8, SAPK1" ENSG00000107643 "Mitogen-activated protein kinase 8" P45983 10 48306639-48439360 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Biological rhythms" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 160.5;Excitatory neurons: 199.1;Inhibitory neurons: 218.2;Oligodendrocyte precursor cells: 233.7;Oligodendrocytes: 163.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004463, CAB069396" Approved NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 6: Brain - Smell perception" "Cluster 44: HDLM-2 - Immune response" "Cluster 29: Early spermatids - Spermatogenesis" "CAB004463: AB_675868, CAB069396: AB_1619977" "unprognostic (7.49e-2)" "unprognostic (1.47e-1)" "unprognostic (2.74e-2)" "unprognostic (1.46e-1)" "unprognostic (3.07e-2)" "unprognostic (1.60e-2)" "prognostic unfavorable (8.66e-4)" "unprognostic (4.23e-2)" "unprognostic (5.98e-2)" "unprognostic (4.31e-3)" "unprognostic (2.33e-1)" "unprognostic (6.06e-2)" "prognostic favorable (8.66e-4)" "unprognostic (1.58e-1)" "unprognostic (9.95e-2)" "unprognostic (1.85e-2)" "unprognostic (1.01e-3)" 7.2 6.7 11.3 7.0 12.6 11.3 13.8 18.3 12.8 8.8 4.5 9.0 10.4 11.0 7.7 9.4 7.5 9.2 7.2 12.5 9.4 13.6 15.6 6.7 7.8 11.6 9.7 11.0 7.5 8.6 7.9 8.3 13.1 8.3 9.9 21.9 9.6 8.2 11.7 6.5 11.2 9.6 8.8 6.7 8.1 13.1 10.9 13.8 14.1 9.6 9.6 8.3 7.0 12.8 29.2 7.2 21.8 12.8 11.3 10.4 16.5 37.9 23.6 20.0 17.8 7.7 19.2 10.9 10.5 21.3 10.7 13.1 10.2 15.2 31.2 45.4 16.5 15.9 6.8 12.7 16.0 24.2 13.2 9.5 18.5 14.4 21.8 12.5 22.0 22.4 25.1 14.5 13.2 8.6 22.1 15.4 14.4 10.0 4.7 17.8 25.8 12.6 17.1 11.1 38.3 34.8 13.5 11.9 16.1 14.8 12.4 11.4 16.7 14.4 31.9 14.6 30.4 6.2 18.0 16.4 14.3 24.9 8.7 0.0 1.1 1.4 1.1 1.1 2.1 0.6 1.7 1.3 1.0 0.8 1.7 1.0 0.8 1.3 1.4 1.8 1.1 1.0 11.3 12.6 18.3 12.8 12.5 9.4 11.6 9.7 13.1 8.8 10.9 12.8 21.2 3.2 17.1 145.3 21.9 44.7 50.6 19.3 20.5 56.2 34.4 17.7 10.0 22.8 18.0 7.3 31.3 15.5 22.3 19.1 11.7 28.9 160.5 25.7 21.9 22.0 31.0 12.4 199.1 25.3 7.4 21.8 16.3 42.9 12.0 25.8 10.4 22.3 9.8 70.7 218.2 16.5 28.5 11.0 34.9 99.2 14.6 18.4 21.4 93.7 25.4 18.9 11.3 233.7 163.0 35.9 22.5 10.1 31.2 39.3 25.4 24.3 16.6 34.6 6.6 23.0 24.5 28.1 28.1 17.5 36.7 15.7 21.6 41.0 11.9 45.5 MAPK9 "JNK2, p54a, PRKM9, SAPK" ENSG00000050748 "Mitogen-activated protein kinase 9" P45984 5 180233143-180292099 "Enzymes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Biological rhythms" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Inhibitory neurons: 64.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 6 "basophil: 16.3" "Lineage enriched" "Detected in all" 6 "granulocytes: 16.3" "Cell line enhanced" "Detected in all" "HDLM-2: 211.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008910, HPA072462" Enhanced Approved "Nuclear speckles,Plasma membrane,Cytosol" NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 39: Non-specific - Mitochondria" "Cluster 44: HDLM-2 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane, Cytosol" "Nuclear speckles" "CAB008910: , HPA072462: " "unprognostic (5.04e-3)" "unprognostic (2.06e-2)" "prognostic favorable (1.11e-4)" "unprognostic (8.53e-2)" "unprognostic (1.75e-1)" "unprognostic (5.06e-3)" "unprognostic (6.83e-3)" "unprognostic (3.16e-1)" "unprognostic (4.93e-2)" "unprognostic (3.76e-1)" "unprognostic (5.97e-2)" "unprognostic (1.36e-1)" "unprognostic (1.50e-1)" "unprognostic (2.13e-1)" "unprognostic (2.29e-1)" "unprognostic (9.38e-3)" "unprognostic (2.40e-1)" 19.3 21.1 28.4 18.4 32.6 21.3 17.5 36.5 41.4 17.7 7.2 22.4 18.5 15.3 16.2 15.4 15.3 13.9 25.7 34.2 25.8 21.1 17.7 19.5 19.9 25.7 19.7 14.6 45.7 30.1 12.9 19.7 26.4 20.0 26.4 21.4 19.1 21.6 40.8 11.7 19.3 19.9 16.9 16.6 22.5 17.8 22.2 22.5 26.7 34.8 21.1 17.4 11.1 29.8 52.7 42.7 37.0 46.5 35.7 39.3 79.4 49.6 43.5 40.5 40.5 56.4 36.7 55.9 83.1 52.6 89.3 39.6 38.4 82.8 47.5 211.8 36.9 23.2 46.8 40.3 27.1 49.0 39.2 29.3 36.5 39.5 38.0 42.5 48.9 43.0 26.2 39.5 55.9 68.9 49.2 20.4 25.8 64.8 25.0 46.9 62.7 26.9 30.8 49.7 42.5 29.9 58.2 55.8 40.4 45.8 56.9 41.7 35.5 48.3 49.2 69.3 75.2 28.2 35.6 37.9 51.5 44.8 32.9 16.3 0.5 2.2 1.6 1.1 1.6 0.8 1.2 1.4 0.8 1.3 0.8 0.9 0.7 1.2 2.3 1.2 2.7 0.3 28.4 32.6 36.5 41.4 34.2 25.8 25.7 19.7 26.4 16.9 22.2 29.8 20.5 32.1 14.4 26.1 10.5 10.1 7.0 6.5 9.1 21.9 16.8 12.2 27.6 12.8 8.5 9.2 16.7 15.3 20.5 20.7 5.9 8.0 1.2 17.6 14.2 12.2 16.7 9.5 62.5 16.0 23.3 11.1 15.8 18.6 11.4 14.5 12.5 16.7 11.7 13.5 64.3 17.9 4.1 24.2 20.5 3.1 10.5 15.0 5.4 31.9 13.9 11.4 15.5 25.1 32.9 13.1 12.3 13.5 15.6 10.2 13.4 11.0 6.9 14.8 13.1 13.5 13.7 17.0 17.1 9.4 11.4 17.8 14.7 8.2 15.4 8.8 MAPKAPK2 MK2 ENSG00000162889 "MAPK activated protein kinase 2" P49137 1 206684905-206734281 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted membrane proteins" "DNA damage" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "dendritic cells: 185.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 6 "plasmacytoid DC: 21.9" "Lineage enriched" "Detected in all" 6 "dendritic cells: 21.9" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010297, HPA045556, HPA063708, HPA064435" Approved Supported Nucleoplasm,Centrosome NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 29: U-266 - Adaptive immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Nucleoplasm Centrosome "CAB010297: AB_2250405, HPA045556: AB_2679367, HPA063708: AB_2685100, HPA064435: AB_2685263" "unprognostic (7.93e-2)" "unprognostic (1.83e-1)" "unprognostic (5.27e-2)" "unprognostic (5.12e-2)" "unprognostic (1.80e-1)" "unprognostic (1.32e-2)" "prognostic unfavorable (1.93e-4)" "unprognostic (9.85e-2)" "unprognostic (1.68e-1)" "unprognostic (2.00e-1)" "unprognostic (1.01e-2)" "unprognostic (1.35e-1)" "prognostic unfavorable (4.58e-6)" "unprognostic (2.12e-1)" "unprognostic (1.37e-1)" "unprognostic (6.96e-2)" "unprognostic (3.29e-2)" 61.9 80.4 34.8 56.2 39.1 174.6 50.5 36.9 33.9 47.3 38.7 50.3 65.5 53.3 24.1 55.8 50.8 52.5 190.1 30.8 36.6 79.5 66.8 79.3 57.8 53.1 42.1 44.8 53.8 38.0 63.3 25.7 43.9 42.8 35.3 17.6 54.9 33.1 196.7 54.4 61.7 45.4 40.1 78.3 68.2 46.9 45.2 45.6 47.7 94.3 54.4 63.5 46.6 38.6 85.4 33.1 44.8 50.6 128.4 75.0 55.1 57.3 130.0 86.0 80.7 63.8 40.4 40.6 38.8 116.9 54.1 63.0 33.8 61.7 61.4 46.5 25.4 69.1 41.7 41.3 99.0 102.3 219.5 104.1 77.3 82.8 91.3 71.8 71.7 54.1 79.7 180.2 70.5 105.2 41.2 73.3 51.5 29.9 45.1 103.7 94.0 13.5 64.9 51.5 35.7 45.7 68.0 114.2 83.1 83.0 55.4 97.2 68.7 77.6 64.7 91.0 79.7 232.0 220.6 33.2 87.8 60.9 26.0 1.6 0.8 1.8 1.8 1.4 1.6 1.1 1.3 1.7 0.7 1.2 0.6 1.2 3.7 2.6 1.3 21.9 1.8 0.7 34.8 39.1 36.9 33.9 30.8 36.6 53.1 42.1 43.9 40.1 45.2 38.6 49.2 54.5 49.9 15.7 27.9 85.4 52.3 18.3 20.5 12.4 61.4 37.8 102.5 37.1 26.8 31.3 20.9 6.4 185.9 51.9 15.6 30.6 76.2 32.2 40.9 43.7 61.7 15.4 4.7 58.5 9.2 33.4 32.1 46.6 34.9 24.8 19.2 40.0 24.8 0.0 10.6 38.1 16.2 34.6 82.7 36.1 22.7 60.9 33.8 13.1 23.7 21.7 74.2 8.5 17.4 61.6 34.4 17.3 69.6 67.3 22.2 25.0 14.4 16.0 26.3 36.9 48.5 13.7 10.3 31.5 72.0 16.6 46.0 19.2 30.5 75.0 MAPKAPK3 "3pK, MAPKAP3, MK-3, MK3" ENSG00000114738 "MAPK activated protein kinase 3" Q16644 3 50611520-50649291 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 4 "bone marrow: 106.5;heart muscle: 256.3;skeletal muscle: 224.2;tongue: 284.3" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 226.6;Hofbauer cells: 102.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 5 "dendritic cells: 142.8;granulocytes: 126.3;monocytes: 341.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA058275 Supported Nucleoplasm NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 32: U-937 - Innate immune response" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm "HPA058275: AB_2683663" "unprognostic (6.46e-3)" "unprognostic (1.84e-1)" "prognostic favorable (8.08e-5)" "unprognostic (1.17e-1)" "unprognostic (1.93e-1)" "unprognostic (9.96e-2)" "unprognostic (8.77e-3)" "unprognostic (7.68e-3)" "unprognostic (1.11e-1)" "unprognostic (5.87e-2)" "unprognostic (2.19e-3)" "unprognostic (1.01e-1)" "prognostic favorable (1.90e-8)" "unprognostic (2.15e-2)" "unprognostic (1.22e-1)" "unprognostic (1.86e-1)" "unprognostic (1.69e-1)" 15.3 43.3 18.0 29.8 19.6 106.5 15.8 19.2 19.2 15.0 21.3 19.7 30.2 11.3 10.3 49.6 15.1 12.1 256.3 18.0 19.7 40.0 18.7 28.2 21.7 23.6 20.5 14.2 36.2 47.2 23.5 13.9 22.5 18.4 20.0 4.7 27.7 12.6 224.2 53.4 24.2 15.9 21.6 25.3 27.6 9.2 21.1 42.0 41.2 284.3 24.2 20.3 22.2 21.6 99.6 30.3 12.4 35.9 18.4 45.7 27.9 23.8 33.7 35.7 30.3 47.1 90.2 39.8 23.5 79.5 88.5 34.6 85.9 92.7 31.9 88.3 22.3 209.5 40.6 43.5 36.8 152.1 106.4 36.9 57.0 83.1 112.2 35.6 31.9 70.2 59.7 25.4 76.1 40.5 65.3 153.3 46.4 34.6 127.0 28.5 29.9 60.1 165.5 56.2 23.0 16.5 21.3 58.9 27.7 20.6 37.8 93.4 23.8 28.1 64.5 146.4 59.5 17.2 33.7 33.1 148.3 234.7 11.8 45.3 169.5 126.3 27.6 271.6 27.3 15.1 30.9 32.1 142.8 8.8 23.9 27.8 104.4 42.1 341.5 91.2 28.0 132.6 18.0 19.6 19.2 19.2 18.0 19.7 23.6 20.5 22.5 21.6 21.1 21.6 3.5 9.6 14.0 8.5 8.6 11.3 26.9 14.0 19.4 1.1 15.3 12.3 226.6 15.7 10.4 11.0 0.0 6.0 38.1 16.2 64.6 45.6 34.5 3.4 2.7 7.1 6.0 19.1 0.3 30.4 7.4 14.9 11.7 5.4 36.2 8.3 5.3 14.2 102.1 0.0 0.7 15.4 10.2 68.0 23.9 86.2 7.2 59.4 7.2 0.0 76.6 17.1 41.2 0.5 2.0 76.2 15.6 3.4 12.7 30.9 30.7 35.4 5.7 2.3 26.3 9.7 12.0 4.1 4.6 34.2 20.2 5.1 24.3 22.0 28.2 33.5 MAPKAPK5 "MK5, PRAK" ENSG00000089022 "MAPK activated protein kinase 5" Q8IW41 12 111842228-111902222 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004546, HPA015515" Supported Supported Nucleoplasm,Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Cytosol" "CAB004546: AB_627910, HPA015515: AB_1853569" "unprognostic (6.45e-2)" "unprognostic (7.29e-2)" "unprognostic (1.27e-3)" "unprognostic (1.09e-2)" "unprognostic (5.52e-2)" "unprognostic (3.76e-2)" "prognostic unfavorable (2.98e-8)" "unprognostic (1.88e-1)" "unprognostic (3.09e-2)" "unprognostic (1.22e-1)" "unprognostic (1.75e-1)" "unprognostic (1.25e-2)" "unprognostic (3.20e-1)" "unprognostic (6.03e-2)" "unprognostic (3.39e-2)" "unprognostic (9.41e-2)" "unprognostic (3.25e-2)" 18.1 20.8 12.6 17.9 14.4 27.1 20.4 14.9 15.0 15.2 15.7 28.2 25.5 15.7 20.7 17.2 16.1 12.2 16.7 15.3 14.3 20.3 19.4 17.5 20.7 12.3 12.4 18.1 20.4 21.4 11.6 20.3 11.8 17.0 30.7 27.2 17.4 15.6 30.4 20.1 28.2 18.9 11.3 15.6 18.0 15.9 12.9 23.2 19.3 25.3 19.3 18.5 14.4 13.8 32.4 42.1 40.0 33.7 28.2 28.4 60.6 31.7 38.1 47.7 32.7 54.8 25.9 48.6 22.9 37.7 28.4 31.6 53.1 33.2 44.4 32.6 29.0 43.4 29.5 44.2 34.1 55.1 29.4 30.2 46.7 45.6 53.7 36.0 35.6 43.4 61.0 18.7 35.3 36.4 55.2 86.6 56.9 79.1 29.4 53.7 29.1 46.9 37.9 46.2 49.0 41.4 36.1 60.5 46.3 36.2 49.1 62.0 31.2 26.8 27.2 27.9 40.4 37.8 50.1 57.4 32.7 39.4 38.9 1.1 3.3 2.3 4.2 2.4 2.2 3.5 2.7 3.0 2.2 3.1 4.2 3.1 1.6 2.9 8.8 2.6 4.8 1.8 12.6 14.4 14.9 15.0 15.3 14.3 12.3 12.4 11.8 11.3 12.9 13.8 16.9 3.2 23.1 12.1 22.3 20.5 22.3 12.5 21.1 47.0 18.3 14.0 20.1 22.8 15.4 3.7 41.7 29.9 32.4 34.1 13.7 28.2 17.2 14.2 17.3 16.0 36.6 15.8 24.6 29.6 33.3 19.4 20.9 15.2 2.5 22.3 14.6 13.4 19.9 23.5 22.3 47.3 14.2 21.2 17.7 7.3 15.5 15.0 8.8 14.0 27.8 19.6 25.7 15.6 21.8 36.3 27.4 17.7 21.6 37.5 63.6 21.8 12.0 36.4 19.7 22.6 19.8 30.7 40.3 23.6 21.3 30.1 22.2 22.5 32.3 32.3 MARCHF1 "FLJ20668, MARCH-I, MARCH1, RNF171" ENSG00000145416 "Membrane associated ring-CH-type finger 1" Q8TCQ1 4 163524298-164384050 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 31.6;retina: 27.5" "Group enriched" "Detected in some" 4 "B-cells: 21.4;Hofbauer cells: 46.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 94 "classical monocyte: 41.8;eosinophil: 25.5;intermediate monocyte: 41.0;memory B-cell: 42.3;myeloid DC: 44.2;naive B-cell: 35.8;non-classical monocyte: 45.4;plasmacytoid DC: 16.5" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "Daudi: 7.1;U-266/70: 7.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014600, HPA048024" Uncertain Supported "Endoplasmic reticulum,Golgi apparatus,Vesicles" NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 16: Immune cells - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 41: Macrophages - Immune response" Vesicles "Endoplasmic reticulum, Golgi apparatus" "HPA014600: AB_1853573, HPA048024: " "unprognostic (7.29e-2)" "unprognostic (5.82e-2)" "unprognostic (1.48e-1)" "unprognostic (9.09e-2)" "unprognostic (8.25e-2)" "unprognostic (2.98e-2)" "unprognostic (4.79e-3)" "unprognostic (9.00e-2)" "unprognostic (3.00e-2)" "unprognostic (2.18e-1)" "unprognostic (1.13e-1)" "unprognostic (2.20e-1)" "unprognostic (1.24e-1)" "unprognostic (7.00e-2)" "unprognostic (2.48e-2)" "unprognostic (2.70e-1)" "unprognostic (2.91e-2)" 6.4 3.5 7.8 21.5 8.1 3.9 2.7 3.6 7.7 3.1 1.8 3.5 3.9 2.5 0.7 3.0 2.8 5.3 1.7 6.6 10.1 1.8 4.1 8.0 31.6 8.0 8.2 2.7 2.8 0.8 2.5 9.9 6.9 2.3 4.5 27.5 3.2 1.2 1.0 4.5 7.0 6.2 7.0 25.8 3.9 1.7 12.1 5.6 2.1 1.0 25.5 7.7 2.9 14.4 0.6 0.5 2.1 1.2 0.0 0.0 1.3 0.9 0.0 0.0 0.0 1.2 2.4 7.1 2.5 0.0 0.2 1.0 0.0 0.0 0.0 0.8 0.7 5.0 3.0 0.5 0.0 3.1 1.6 0.0 0.0 0.0 0.1 2.8 0.0 1.3 1.9 3.6 2.4 0.7 1.8 1.9 2.6 0.2 0.9 2.0 0.3 0.5 0.1 1.1 1.0 0.9 0.6 1.0 0.4 1.4 2.9 0.5 2.3 0.8 1.4 0.5 1.7 7.0 2.5 1.9 0.9 1.5 1.1 0.0 41.8 25.5 0.1 41.0 0.0 42.3 0.1 0.0 44.2 35.8 0.0 0.0 0.3 0.3 45.4 16.5 0.0 18.4 7.8 8.1 3.6 7.7 6.6 10.1 8.0 8.2 6.9 7.0 12.1 14.4 0.1 0.0 0.0 0.0 21.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.3 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.5 0.2 0.0 0.0 0.0 0.0 0.0 0.0 46.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.8 0.1 0.0 0.0 0.0 MARCHF10 "FLJ35757, MARCH-X, MARCH10, RNF190" ENSG00000173838 "Membrane associated ring-CH-type finger 10" Q8NA82 17 62701314-62808344 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 11 "testis: 137.6" "Not detected" "Not detected" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 2.5;EFO-21: 4.7;HSkMC: 2.1;SCLC-21H: 8.3" "Low region specificity" "Detected in single" "Low region specificity" "Detected in some" HPA023322 Enhanced Approved "Plasma membrane,Cytosol" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 49: Ciliated cells - Cilium organization" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 24: Non-specific - Transcription regulation" "Plasma membrane, Cytosol" "HPA023322: AB_1856351" "unprognostic (2.79e-2)" "unprognostic (2.32e-1)" "unprognostic (9.60e-3)" "unprognostic (6.95e-2)" "unprognostic (1.21e-1)" "unprognostic (1.21e-1)" "unprognostic (1.03e-2)" "unprognostic (1.67e-1)" "unprognostic (1.39e-1)" "unprognostic (7.99e-4)" "unprognostic (3.16e-1)" "unprognostic (2.85e-3)" "unprognostic (1.38e-1)" "unprognostic (4.83e-2)" "unprognostic (9.37e-3)" "unprognostic (2.66e-1)" 0.1 0.2 1.3 0.2 1.6 0.0 0.1 1.2 0.9 1.4 10.5 1.1 0.0 0.4 7.5 0.1 12.8 0.1 0.1 1.1 1.3 1.5 0.0 2.7 0.0 3.6 5.0 0.1 0.2 0.3 12.7 0.0 2.6 0.6 0.0 0.1 0.3 0.1 0.0 0.2 0.4 0.0 3.6 0.1 0.4 137.6 1.3 0.2 0.1 0.0 0.0 0.1 0.2 2.0 0.1 0.0 0.1 0.0 0.0 0.1 2.5 1.1 0.1 0.8 0.2 0.0 0.0 0.0 4.7 0.3 0.1 0.0 0.0 0.2 0.9 0.0 0.0 0.8 0.6 0.0 1.0 0.0 0.0 2.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.6 1.0 0.1 0.0 0.2 0.0 0.1 0.0 0.0 0.1 0.7 0.0 8.3 0.0 0.0 0.5 0.0 0.3 0.1 0.0 0.0 0.0 0.4 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.9 0.0 0.3 0.0 0.1 0.1 0.2 0.0 0.1 0.4 0.0 0.1 0.0 0.0 0.2 0.1 1.3 1.6 1.2 0.9 1.1 1.3 3.6 5.0 2.6 3.6 1.3 2.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 MARCHF11 "MARCH-XI, MARCH11, RNF226" ENSG00000183654 "Membrane associated ring-CH-type finger 11" A6NNE9 5 16067139-16180762 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 8 "testis: 82.4" "Cell type enriched" "Detected in single" 30 "Cardiomyocytes: 6.1" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 11 "SH-SY5Y: 83.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 54: Cardiomyocytes - Muscle contraction" "unprognostic (9.91e-3)" "unprognostic (1.08e-1)" "unprognostic (2.98e-1)" "unprognostic (1.50e-1)" "unprognostic (1.54e-1)" "unprognostic (1.52e-1)" "unprognostic (3.55e-2)" 0.1 0.7 4.7 0.0 4.6 0.0 0.3 5.0 6.7 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.9 5.7 6.7 0.2 0.1 0.0 0.0 5.7 4.7 0.3 1.3 0.0 9.9 0.0 5.0 0.3 0.0 3.6 1.0 0.0 0.0 0.1 0.0 0.0 3.8 0.0 0.1 82.4 4.8 0.0 0.0 0.0 0.0 0.0 0.1 4.7 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.0 83.8 0.0 0.0 0.0 7.5 0.0 0.0 0.0 1.5 0.3 0.0 0.0 1.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.7 4.6 5.0 6.7 5.7 6.7 5.7 4.7 5.0 3.8 4.8 4.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 MARCHF2 "HSPC240, MARCH-II, MARCH2, RNF172" ENSG00000099785 "Membrane associated ring-CH-type finger 2" Q9P0N8 19 8413270-8439017 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Endocytosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Adipocytes: 23.1;Cardiomyocytes: 42.3;Extravillous trophoblasts: 11.6;Hofbauer cells: 66.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA014063 Approved Supported "Endoplasmic reticulum,Cytosol" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 3: HMC-1 - Innate immune response" "Cluster 24: Non-specific - Transcription regulation" "Endoplasmic reticulum" Cytosol "HPA014063: AB_1853576" "unprognostic (1.15e-2)" "unprognostic (4.01e-3)" "prognostic unfavorable (6.48e-4)" "prognostic favorable (1.05e-5)" "unprognostic (3.00e-1)" "prognostic favorable (8.29e-4)" "unprognostic (3.43e-2)" "unprognostic (6.95e-2)" "unprognostic (3.06e-3)" "unprognostic (2.32e-1)" "prognostic favorable (6.21e-4)" "unprognostic (2.01e-1)" "unprognostic (3.52e-1)" "unprognostic (1.01e-1)" "unprognostic (3.16e-1)" "unprognostic (9.91e-2)" "unprognostic (1.80e-2)" 65.7 33.0 102.2 20.3 101.5 29.4 49.8 99.5 106.6 24.2 66.4 96.2 15.7 34.4 53.9 32.4 27.1 15.3 101.1 90.9 94.3 35.6 59.1 41.9 19.5 113.7 102.5 15.8 19.2 15.3 30.5 19.8 106.0 40.8 14.0 9.1 25.5 28.8 89.5 34.5 31.4 30.1 109.2 51.2 32.9 18.9 105.1 14.2 47.9 48.6 14.5 49.8 26.1 96.7 11.4 14.2 6.3 29.5 37.9 12.6 10.7 12.3 14.7 9.5 9.8 7.0 5.5 4.4 34.8 26.7 12.6 8.1 8.2 17.5 7.3 22.7 20.3 34.2 6.6 15.9 20.5 5.0 49.6 14.7 20.1 9.2 8.1 13.9 38.2 17.8 4.9 24.5 7.5 21.5 7.0 16.7 13.3 14.0 34.2 11.0 2.0 11.4 22.4 13.9 3.1 17.7 0.8 12.9 24.2 21.5 10.2 10.8 38.9 13.3 8.4 44.5 10.4 21.7 28.2 5.0 21.6 10.2 10.7 52.6 18.5 31.3 10.6 28.6 10.8 7.2 10.6 8.6 13.1 7.3 7.2 9.6 23.4 7.9 25.7 51.8 14.9 17.4 102.2 101.5 99.5 106.6 90.9 94.3 113.7 102.5 106.0 109.2 105.1 96.7 23.1 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 42.3 0.0 0.0 0.0 0.0 8.1 9.9 0.0 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 11.6 7.7 0.0 0.0 0.0 0.0 0.0 0.0 66.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.6 0.0 0.0 0.0 0.0 5.7 1.5 0.0 0.0 0.0 MARCHF3 "MARCH-III, MARCH3, MGC48332, RNF173" ENSG00000173926 "Membrane associated ring-CH-type finger 3" Q86UD3 5 126867714-127030558 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Endocytosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in some" 4 "Cytotrophoblasts: 43.8;Syncytiotrophoblasts: 98.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "memory B-cell: 10.5;naive B-cell: 12.1" "Lineage enriched" "Detected in many" 4 "B-cells: 12.1" "Cell line enhanced" "Detected in many" "hTEC/SVTERT24-B: 40.4;HUVEC TERT2: 27.4;TIME: 33.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043406 Uncertain Supported Vesicles NA NA "Cluster 37: B-cells - Transcription" "Cluster 77: Retina - Visual perception" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Vesicles "HPA043406: AB_10793947" "unprognostic (5.96e-3)" "unprognostic (1.46e-2)" "unprognostic (1.91e-2)" "unprognostic (4.21e-2)" "unprognostic (9.00e-3)" "unprognostic (1.17e-2)" "unprognostic (7.75e-3)" "unprognostic (9.41e-2)" "unprognostic (8.93e-2)" "unprognostic (2.05e-3)" "unprognostic (3.15e-2)" "unprognostic (1.82e-1)" "unprognostic (5.60e-6)" "unprognostic (7.74e-2)" "unprognostic (7.64e-2)" "unprognostic (1.05e-1)" "unprognostic (3.64e-1)" 5.6 2.8 6.1 2.9 5.6 3.7 2.6 5.3 4.1 0.9 1.9 5.3 0.9 1.4 0.0 1.4 1.5 5.2 7.8 3.9 5.7 0.8 0.7 2.4 2.5 11.5 7.1 1.1 2.4 0.3 2.4 1.7 7.9 0.6 5.6 7.4 4.6 0.2 6.5 5.8 2.4 2.9 8.3 1.6 2.4 5.6 7.8 1.3 1.4 3.3 2.1 7.6 0.7 8.5 0.4 1.8 3.9 2.1 3.4 3.2 1.2 14.2 5.9 11.1 16.3 1.9 0.8 3.8 1.3 1.9 2.4 1.1 4.9 2.5 15.3 0.8 4.7 12.2 3.2 1.9 5.6 5.0 3.0 2.4 0.7 40.4 4.8 2.6 27.4 0.6 5.1 0.7 9.3 1.3 0.5 2.3 3.3 3.0 4.6 1.5 15.5 1.2 0.9 2.0 1.3 0.9 3.3 0.5 1.6 1.9 2.9 5.0 33.5 2.2 1.8 12.6 1.6 1.9 2.3 2.3 8.3 3.8 2.0 0.0 0.2 2.8 0.5 0.4 0.1 10.5 0.6 0.3 0.1 12.1 2.3 0.5 0.8 2.3 0.3 0.7 2.9 0.8 6.1 5.6 5.3 4.1 3.9 5.7 11.5 7.1 7.9 8.3 7.8 8.5 3.8 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.4 0.0 0.0 0.0 0.0 43.8 5.7 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 3.2 5.8 0.0 0.0 0.0 0.0 0.0 0.0 8.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 98.6 0.6 0.0 0.0 0.0 MARCHF4 "KIAA1399, MARCH-IV, MARCH4, RNF174" ENSG00000144583 "Membrane associated ring-CH-type finger 4" Q9P2E8 2 216257865-216372483 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Group enriched" "Detected in some" 4 "brain: 4.4;pituitary gland: 6.2" "Not detected" "Not detected" "Cancer enhanced" "Detected in some" "pancreatic cancer: 1.2" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ: 69.0;fHDF/TERT166: 43.8;TIME: 32.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA014348 Approved NA NA "Cluster 65: Brain - Ion transport" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 43: Cardiomyocytes - Nuclear processes" "HPA014348: AB_1853578" "unprognostic (4.84e-2)" "unprognostic (1.02e-4)" "unprognostic (1.63e-1)" "unprognostic (5.42e-2)" "unprognostic (3.31e-2)" "unprognostic (1.88e-1)" "unprognostic (1.38e-1)" "unprognostic (1.26e-2)" "unprognostic (1.24e-2)" "unprognostic (6.49e-2)" "unprognostic (5.55e-3)" "unprognostic (1.07e-1)" "unprognostic (6.81e-5)" "unprognostic (4.82e-2)" "unprognostic (2.06e-1)" "unprognostic (1.23e-1)" "unprognostic (1.09e-3)" 0.0 0.7 2.6 0.0 3.9 0.0 0.0 0.0 4.4 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.6 0.0 0.0 3.1 2.2 0.0 0.0 0.0 0.0 0.5 4.1 0.0 0.4 0.0 6.2 0.6 1.1 0.0 0.2 0.6 0.0 0.0 0.0 0.1 0.2 0.0 2.7 0.0 1.3 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 12.5 2.5 0.0 0.0 0.2 1.6 0.0 69.0 23.2 14.5 5.1 0.1 1.0 0.0 10.5 43.8 24.2 0.1 0.0 26.7 14.1 0.0 0.0 5.1 0.0 0.0 3.4 0.0 0.0 0.1 0.0 13.3 19.6 9.3 19.0 0.0 0.0 0.0 22.6 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 11.4 1.9 0.1 0.0 0.0 2.2 0.0 0.0 32.7 22.7 23.9 0.1 18.6 0.0 0.0 0.0 5.2 0.0 16.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 3.9 0.0 4.4 3.1 2.2 0.5 4.1 1.1 2.7 1.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 MARCHF5 "FLJ20445, MARCH-V, MARCH5, MITOL, RNF153" ENSG00000198060 "Membrane associated ring-CH-type finger 5" Q9NX47 10 92291167-92353964 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Adipocytes: 23.8;Cardiomyocytes: 28.6;Cytotrophoblasts: 39.2;Extravillous trophoblasts: 44.0;Hofbauer cells: 34.9;Syncytiotrophoblasts: 65.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056596 Supported Mitochondria NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 24: Non-specific - Transcription regulation" Mitochondria "HPA056596: AB_2683181" "unprognostic (4.00e-2)" "unprognostic (5.15e-2)" "unprognostic (1.25e-1)" "unprognostic (4.10e-2)" "unprognostic (5.47e-3)" "unprognostic (2.33e-3)" "unprognostic (4.43e-1)" "unprognostic (1.63e-1)" "unprognostic (1.24e-2)" "unprognostic (9.77e-2)" "unprognostic (5.50e-3)" "unprognostic (4.02e-3)" "unprognostic (6.14e-2)" "unprognostic (2.87e-1)" "unprognostic (1.62e-1)" "unprognostic (4.53e-1)" "unprognostic (2.85e-2)" 13.6 14.0 9.1 7.7 9.6 17.3 15.0 9.1 11.9 12.2 10.4 9.8 11.3 13.3 12.6 19.3 10.1 10.7 12.8 9.6 9.4 15.1 20.1 10.4 9.0 9.0 9.4 14.0 9.2 12.5 7.0 7.8 8.8 15.1 10.1 8.8 13.7 7.8 18.2 9.8 11.6 10.7 9.6 8.9 10.5 8.8 9.3 12.5 17.2 16.1 9.8 10.7 12.2 9.7 28.0 14.8 28.7 33.1 19.2 19.8 14.8 24.5 26.7 29.8 30.4 10.0 19.6 16.2 16.5 24.1 13.0 22.4 20.3 20.5 42.5 12.3 23.9 13.1 13.6 23.7 23.2 21.1 12.4 20.4 27.0 19.7 40.9 39.6 26.6 17.0 14.5 19.7 24.2 17.7 18.7 24.1 6.7 18.1 22.1 20.0 29.4 9.8 30.8 17.8 13.3 24.5 21.3 15.5 26.7 13.7 27.1 16.1 26.0 13.9 15.3 15.3 34.0 19.9 16.2 14.2 12.7 28.7 9.5 4.2 6.0 7.0 5.1 7.5 5.2 5.2 5.7 5.5 6.9 4.5 5.7 5.5 12.2 5.0 6.7 4.6 5.9 5.0 9.1 9.6 9.1 11.9 9.6 9.4 9.0 9.4 8.8 9.6 9.3 9.7 23.8 0.0 0.0 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 28.6 0.0 0.0 0.0 0.0 39.2 12.9 0.0 0.0 0.0 0.0 0.0 0.0 3.5 0.0 0.0 0.0 0.0 44.0 9.3 0.0 0.0 0.0 0.0 0.0 0.0 34.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.4 0.0 0.0 0.0 0.0 65.3 2.8 0.0 0.0 0.0 MARCHF6 "MARCH-VI, MARCH6, RNF176, TEB4" ENSG00000145495 "Membrane associated ring-CH-type finger 6" O60337 5 10353695-10440388 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase Epilepsy "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Adipocytes: 38.5;Cardiomyocytes: 102.5;Cytotrophoblasts: 54.4;dendritic cells: 25.8;Extravillous trophoblasts: 30.0;Hofbauer cells: 36.4;Syncytiotrophoblasts: 81.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040841, HPA063246" Approved Supported "Endoplasmic reticulum" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 3: T-cells - Adaptive immune response" "Cluster 20: HeLa - Mitochondria" "Cluster 24: Non-specific - Transcription regulation" "Endoplasmic reticulum" "HPA040841: AB_2677162, HPA063246: AB_2684970" "unprognostic (3.31e-2)" "unprognostic (2.04e-1)" "unprognostic (2.85e-2)" "unprognostic (3.80e-3)" "unprognostic (4.00e-1)" "unprognostic (2.26e-1)" "unprognostic (3.06e-2)" "unprognostic (9.52e-3)" "unprognostic (1.53e-1)" "unprognostic (1.05e-3)" "unprognostic (3.94e-2)" "unprognostic (5.58e-2)" "unprognostic (5.08e-3)" "unprognostic (1.61e-1)" "unprognostic (2.88e-1)" "unprognostic (3.57e-1)" "unprognostic (8.50e-3)" 22.1 25.5 16.1 20.3 23.7 76.5 25.9 28.3 20.7 20.1 2.9 26.9 32.8 22.7 25.5 20.9 24.9 24.5 30.8 22.0 30.4 34.1 32.5 25.1 24.7 13.7 17.5 36.0 39.3 62.4 20.8 22.8 16.9 22.7 19.8 36.6 25.6 23.8 48.4 24.8 30.3 18.9 13.8 28.2 30.2 29.9 27.9 32.3 29.3 51.8 23.3 23.7 18.6 33.5 37.4 55.1 90.1 69.9 50.6 40.4 73.7 57.7 53.7 48.9 61.8 52.8 97.0 39.4 85.4 54.4 67.2 52.3 48.2 37.7 65.4 82.9 43.0 50.7 179.7 36.2 35.6 61.4 54.6 47.4 40.6 49.0 53.1 50.0 45.8 41.4 62.1 85.1 45.0 42.4 33.1 47.2 32.8 29.9 38.5 50.9 37.6 57.0 38.0 72.4 38.7 56.0 107.2 57.9 38.4 41.3 48.2 32.5 44.8 58.4 56.8 29.1 43.7 59.3 94.1 55.7 43.1 40.7 42.8 15.6 7.4 12.6 11.2 8.4 12.8 11.7 10.8 11.0 6.3 9.6 12.5 12.4 12.1 9.1 11.1 5.0 10.4 9.1 16.1 23.7 28.3 20.7 22.0 30.4 13.7 17.5 16.9 13.8 27.9 33.5 38.5 0.0 0.0 0.0 13.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 102.5 0.0 0.0 0.0 0.0 54.4 25.8 0.0 0.0 0.0 0.0 0.0 0.0 10.4 0.0 0.0 0.0 0.0 30.0 19.3 0.0 0.0 0.0 0.0 0.0 0.0 36.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.0 0.0 0.0 0.0 0.0 81.3 5.8 0.0 0.0 0.0 MARCHF7 "AXOT, MARCH-VII, MARCH7, RNF177" ENSG00000136536 "Membrane associated ring-CH-type finger 7" Q9H992 2 159712457-159771027 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Adipocytes: 33.3;Cardiomyocytes: 88.4;Cytotrophoblasts: 36.2;dendritic cells: 28.2;Extravillous trophoblasts: 38.8;Hofbauer cells: 34.0;Syncytiotrophoblasts: 44.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014275, HPA022152" Enhanced Supported "Plasma membrane,Cytosol" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 23: Testis - Cell cycle regulation" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 24: Non-specific - Transcription regulation" "Plasma membrane, Cytosol" "HPA014275: AB_10599820, HPA022152: AB_10601107" "unprognostic (2.42e-1)" "unprognostic (2.24e-1)" "unprognostic (1.02e-2)" "unprognostic (1.92e-2)" "unprognostic (1.62e-2)" "unprognostic (2.10e-1)" "prognostic unfavorable (2.41e-4)" "unprognostic (2.46e-2)" "unprognostic (6.42e-2)" "unprognostic (3.44e-1)" "unprognostic (3.17e-2)" "unprognostic (3.53e-2)" "prognostic unfavorable (1.84e-4)" "unprognostic (1.41e-3)" "unprognostic (1.38e-1)" "unprognostic (2.57e-1)" "unprognostic (1.61e-1)" 38.3 30.0 16.4 37.9 21.7 43.2 48.2 32.3 21.5 38.6 25.1 33.2 30.0 45.0 34.2 67.3 37.5 38.1 48.9 15.8 16.1 32.8 40.1 38.2 47.9 17.4 17.1 47.5 22.3 36.6 22.7 46.9 17.7 38.1 36.9 37.9 26.9 36.3 55.2 38.6 30.0 50.6 14.9 45.1 33.5 62.0 17.1 60.8 47.5 44.1 52.2 39.0 37.5 21.8 50.3 35.3 88.7 40.7 61.9 81.9 89.1 83.9 81.1 82.5 73.9 70.9 57.5 71.0 36.8 84.2 46.8 61.3 55.4 74.5 102.9 75.9 43.2 96.0 53.8 53.3 60.7 79.9 72.6 72.7 83.0 99.5 86.5 92.5 99.3 50.7 75.6 65.6 82.9 44.2 52.4 73.8 84.6 54.6 47.3 75.0 64.5 59.3 74.6 112.1 51.9 48.6 65.6 48.2 67.0 94.3 56.9 94.4 93.5 86.9 51.9 53.9 47.2 51.5 61.0 96.8 54.1 46.8 84.0 83.5 28.8 59.6 28.6 29.5 33.3 27.6 30.4 32.4 27.6 26.4 36.3 35.9 127.5 39.4 43.4 22.3 34.3 30.9 16.4 21.7 32.3 21.5 15.8 16.1 17.4 17.1 17.7 14.9 17.1 21.8 33.3 0.0 0.0 0.0 7.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 88.4 0.0 0.0 0.0 0.0 36.2 28.2 0.0 0.0 0.0 0.0 0.0 0.0 8.9 0.0 0.0 0.0 0.0 38.8 13.5 0.0 0.0 0.0 0.0 0.0 0.0 34.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.0 0.0 0.0 0.0 0.0 44.2 5.8 0.0 0.0 0.0 MARCHF8 "c-MIR, CMIR, MARCH-VIII, MARCH8, MIR, RNF178" ENSG00000165406 "Membrane associated ring-CH-type finger 8" Q5T0T0 10 45454585-45594906 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Adaptive immunity, Immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in some" 4 "Cardiomyocytes: 26.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA014597 Approved NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 44: HDLM-2 - Immune response" "Cluster 24: Non-specific - Transcription regulation" "HPA014597: AB_1853580" "unprognostic (1.38e-1)" "unprognostic (3.69e-2)" "unprognostic (1.74e-1)" "unprognostic (1.68e-3)" "unprognostic (1.32e-1)" "unprognostic (2.01e-2)" "unprognostic (3.51e-1)" "unprognostic (2.58e-1)" "unprognostic (1.56e-2)" "unprognostic (2.04e-1)" "prognostic favorable (2.71e-4)" "unprognostic (1.28e-1)" "prognostic favorable (6.64e-4)" "unprognostic (1.01e-1)" "unprognostic (1.24e-1)" "unprognostic (1.85e-1)" "unprognostic (3.12e-2)" 14.3 19.2 11.8 12.4 18.5 49.1 16.8 19.3 13.1 13.8 11.7 21.3 14.2 14.4 10.4 10.6 15.3 13.4 20.5 11.1 13.1 15.5 16.9 15.0 16.9 18.8 14.2 19.5 26.5 19.8 16.0 12.2 17.3 11.5 18.3 18.2 14.8 15.2 14.7 10.5 22.4 13.8 14.7 18.7 14.4 57.1 16.1 17.8 16.3 15.4 20.3 11.4 9.0 26.7 16.6 16.4 13.7 12.4 19.4 24.2 10.1 7.5 35.0 13.6 14.8 4.2 16.8 23.8 12.6 21.9 12.3 3.0 15.2 12.4 12.6 36.3 16.7 9.2 7.4 10.0 13.6 11.3 39.1 19.8 16.3 6.8 17.9 13.4 22.5 22.4 26.5 23.2 10.5 5.8 11.5 7.1 4.5 2.4 5.3 12.7 13.7 7.0 10.2 9.5 12.2 17.0 14.7 3.5 14.0 13.3 21.2 5.2 15.1 10.6 13.6 15.6 12.0 39.8 34.2 10.5 21.0 15.5 2.9 13.9 1.1 10.8 3.0 1.9 4.5 3.5 3.4 3.3 1.6 5.4 2.5 3.2 14.1 8.5 0.9 1.6 3.6 2.5 11.8 18.5 19.3 13.1 11.1 13.1 18.8 14.2 17.3 14.7 16.1 26.7 6.1 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 26.6 0.0 0.0 0.0 0.0 2.0 6.3 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 1.7 2.8 0.0 0.0 0.0 0.0 0.0 0.0 6.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 0.0 0.0 0.0 0.0 1.6 1.3 0.0 0.0 0.0 MARCHF9 "FLJ36578, MARCH9, RNF179" ENSG00000139266 "Membrane associated ring-CH-type finger 9" Q86YJ5 12 57755103-57760411 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in some" 4 "Adipocytes: 6.0;B-cells: 6.6;Cardiomyocytes: 12.3;dendritic cells: 12.0;Hofbauer cells: 7.3;Plasma cells: 8.3;T-cells: 3.4" "Cancer enriched" "Detected in all" 4 "glioma: 39.3" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in many" 12 "RH-30: 515.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 77: Retina - Visual perception" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 24: Non-specific - Transcription regulation" "unprognostic (2.96e-2)" "unprognostic (6.78e-2)" "unprognostic (1.90e-3)" "prognostic favorable (3.07e-4)" "unprognostic (2.16e-1)" "unprognostic (6.85e-2)" "unprognostic (8.15e-3)" "prognostic favorable (1.54e-5)" "unprognostic (7.76e-2)" "prognostic favorable (1.59e-4)" "unprognostic (1.08e-2)" "unprognostic (1.06e-1)" "prognostic favorable (2.98e-5)" "unprognostic (2.44e-1)" "unprognostic (2.86e-1)" "unprognostic (2.45e-1)" "unprognostic (1.34e-1)" 8.8 17.6 15.3 7.8 16.0 5.1 10.0 17.7 16.9 11.3 14.5 13.5 7.6 9.0 8.4 12.6 8.4 6.4 17.3 15.6 16.1 28.0 8.6 19.0 13.9 14.8 15.2 8.9 17.4 17.9 34.9 7.7 14.2 16.5 6.5 40.6 14.3 8.5 13.0 17.9 20.0 4.7 14.6 29.0 14.8 5.2 15.5 19.4 25.4 9.0 13.8 9.8 10.0 14.3 15.3 7.5 11.6 12.7 1.2 0.4 15.0 2.3 16.0 8.8 8.5 9.7 12.0 37.3 12.1 0.4 15.2 13.6 19.1 16.3 5.7 22.4 21.1 4.8 5.9 5.0 10.7 4.6 7.5 1.8 16.8 2.5 8.9 26.0 3.8 36.9 6.9 37.1 2.3 14.5 24.3 5.8 7.6 10.8 16.1 19.9 515.3 40.6 17.5 13.4 26.1 17.1 1.1 1.2 10.4 5.6 26.4 9.1 0.3 11.4 9.1 6.5 7.5 41.8 20.4 22.6 12.5 1.1 11.7 2.0 0.4 0.1 3.2 0.6 5.0 4.6 5.1 4.4 1.4 5.8 5.0 3.7 0.2 2.6 0.2 9.8 3.3 1.1 15.3 16.0 17.7 16.9 15.6 16.1 14.8 15.2 14.2 14.6 15.5 14.3 6.0 0.0 0.0 0.0 6.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.3 0.0 0.0 0.0 0.0 1.9 12.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.8 1.6 0.0 0.0 0.0 0.0 0.0 0.0 7.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 1.1 3.4 0.0 0.0 0.0 MARK1 "MARK, PAR-1C" ENSG00000116141 "Microtubule affinity regulating kinase 1" Q9P0L2 1 220528136-220664461 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Autism, Autism spectrum disorder" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 73.8;Excitatory neurons: 171.3;Inhibitory neurons: 170.1;Oligodendrocyte precursor cells: 167.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HAP1: 11.3;RT4: 33.7;SuSa: 12.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007421, HPA008061" Uncertain NA NA "Cluster 77: Retina - Visual perception" "Cluster 15: RT4 - Unknown function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA007421: AB_1079311, HPA008061: AB_1079310" "unprognostic (1.51e-1)" "unprognostic (6.27e-2)" "unprognostic (6.72e-2)" "unprognostic (3.63e-2)" "unprognostic (2.23e-1)" "unprognostic (1.01e-1)" "unprognostic (1.54e-2)" "unprognostic (3.48e-1)" "prognostic unfavorable (2.63e-4)" "unprognostic (4.59e-2)" "prognostic favorable (2.23e-5)" "unprognostic (6.62e-2)" "unprognostic (4.27e-2)" "unprognostic (9.56e-3)" "unprognostic (3.35e-2)" "unprognostic (1.72e-1)" "unprognostic (3.74e-2)" 6.3 1.8 6.9 1.4 7.1 0.0 4.9 6.4 10.0 4.6 8.4 5.4 0.4 4.2 9.7 4.8 3.3 1.7 8.0 7.4 6.7 2.3 0.3 3.1 0.5 6.4 6.8 1.7 0.9 2.4 6.9 1.1 7.4 3.0 1.2 9.3 3.7 4.0 2.2 2.5 2.5 3.9 5.7 1.3 2.8 6.9 6.5 1.4 4.3 3.5 1.9 5.3 5.1 6.4 0.4 0.0 5.4 1.1 0.0 0.0 1.8 1.6 2.2 1.8 2.5 0.0 0.0 0.0 0.0 0.0 2.5 2.5 11.3 6.0 1.0 0.0 8.4 0.0 2.3 0.0 0.0 0.7 0.8 0.9 4.7 0.0 3.0 0.8 0.2 2.7 0.0 0.0 0.0 0.0 0.0 0.0 8.1 5.5 1.8 0.0 7.4 0.0 0.0 33.7 6.4 6.2 0.3 0.3 0.5 12.2 0.5 0.0 0.0 0.0 2.4 4.0 7.1 0.0 0.0 0.0 1.2 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.9 7.1 6.4 10.0 7.4 6.7 6.4 6.8 7.4 5.7 6.5 6.4 3.2 0.0 0.5 73.8 0.5 3.4 2.6 10.0 13.1 28.6 1.6 3.8 21.9 0.0 4.7 3.7 31.3 2.1 0.0 0.7 0.0 1.6 7.3 19.3 6.4 3.4 9.0 0.0 171.3 0.0 2.3 6.3 2.6 35.5 0.0 13.6 3.3 0.0 0.3 10.1 170.1 0.4 4.1 0.3 1.5 3.6 2.1 0.2 0.0 15.0 0.0 12.3 0.0 167.9 45.9 0.1 0.0 6.4 0.6 4.8 1.5 0.2 4.1 11.9 0.0 6.9 17.5 17.4 5.1 13.1 3.3 1.0 0.4 1.1 0.9 4.8 MARK2 "EMK1, PAR-1, PAR-1B, Par1b" ENSG00000072518 "Microtubule affinity regulating kinase 2" Q7KZI7 11 63838928-63911020 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Differentiation, Wnt signaling pathway" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038790, HPA074905" Approved Supported "Nucleoplasm,Plasma membrane" NA NA "Cluster 10: Basophils - Unknown function" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane" Nucleoplasm "HPA038790: AB_10674840, HPA074905: AB_2686722" "unprognostic (1.33e-2)" "unprognostic (2.45e-2)" "unprognostic (1.64e-1)" "prognostic unfavorable (3.21e-4)" "unprognostic (7.13e-2)" "unprognostic (3.82e-2)" "prognostic unfavorable (1.30e-4)" "unprognostic (2.73e-3)" "unprognostic (4.41e-1)" "unprognostic (5.79e-2)" "unprognostic (3.94e-3)" "unprognostic (3.77e-1)" "unprognostic (5.20e-3)" "unprognostic (5.15e-3)" "unprognostic (6.78e-2)" "unprognostic (1.03e-1)" "unprognostic (2.40e-1)" 11.3 13.8 12.6 21.1 16.1 24.0 16.8 8.1 16.3 18.5 10.8 25.9 26.1 14.6 7.7 51.8 16.6 14.1 20.9 14.9 9.3 13.9 13.1 17.0 21.5 11.8 9.3 12.0 22.4 19.4 19.8 14.9 11.5 20.5 22.4 8.8 27.0 13.1 20.8 40.9 25.1 16.3 7.3 24.1 20.9 10.6 9.5 23.2 19.5 13.7 24.0 19.3 25.0 17.9 52.0 34.1 26.6 28.6 14.6 18.6 35.2 20.8 20.0 29.5 22.3 34.1 49.5 37.8 35.6 20.8 32.0 57.5 26.9 28.7 24.6 26.7 20.9 40.7 23.9 20.3 17.0 45.9 51.4 10.9 36.8 27.0 21.4 13.5 24.7 33.6 35.7 36.5 19.5 64.4 49.3 29.9 31.7 36.0 24.2 39.9 20.4 39.7 19.1 39.8 37.9 25.4 34.7 90.2 24.3 28.9 65.1 26.4 22.7 30.3 19.1 39.6 23.4 24.5 28.8 36.7 20.1 23.2 25.3 1.4 0.7 2.1 1.3 0.7 2.1 0.9 1.0 1.3 1.0 1.6 0.8 0.9 3.6 1.6 1.1 0.9 0.6 0.7 12.6 16.1 8.1 16.3 14.9 9.3 11.8 9.3 11.5 7.3 9.5 17.9 17.3 6.4 6.8 29.7 18.5 25.2 21.1 9.1 19.4 26.8 30.0 18.2 12.8 27.1 11.9 20.2 8.4 26.0 33.4 90.3 1.9 20.2 0.6 29.5 15.8 14.7 29.9 14.7 43.6 21.4 20.6 11.7 27.0 41.0 17.2 21.1 13.6 13.0 17.9 20.2 30.3 39.9 10.2 26.7 18.5 0.9 12.8 25.0 3.6 29.0 17.0 18.8 36.0 31.7 51.8 27.3 39.4 10.9 15.6 30.4 33.4 8.1 14.5 18.1 19.7 19.6 13.1 9.1 18.4 39.9 34.4 65.0 23.6 16.0 33.6 44.3 MARK3 "CTAK1, KP78, PAR-1A" ENSG00000075413 "Microtubule affinity regulating kinase 3" P27448 14 103385377-103503831 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 32 "eosinophil: 101.5" "Lineage enriched" "Detected in all" 32 "granulocytes: 101.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024652 Approved NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 30: Epithelial cell lines - Translation" "Cluster 52: Non-specific - Transcription" "HPA024652: AB_1853582" "unprognostic (6.86e-2)" "unprognostic (2.93e-1)" "unprognostic (7.70e-2)" "unprognostic (3.48e-2)" "unprognostic (8.41e-2)" "unprognostic (1.50e-1)" "unprognostic (2.31e-3)" "unprognostic (2.21e-1)" "prognostic unfavorable (1.14e-4)" "unprognostic (2.29e-3)" "unprognostic (3.66e-2)" "unprognostic (1.55e-2)" "unprognostic (1.13e-1)" "unprognostic (4.71e-2)" "unprognostic (1.34e-1)" "unprognostic (1.33e-2)" "unprognostic (1.60e-1)" 34.6 52.5 14.9 23.0 15.9 53.2 27.5 16.0 22.1 29.8 15.1 34.8 20.4 31.3 26.7 39.8 36.8 20.8 71.5 14.5 14.8 38.7 30.8 38.3 24.9 15.1 15.0 33.7 46.7 33.8 32.0 22.8 16.2 30.5 21.3 23.2 29.2 24.2 71.0 27.3 31.8 30.8 15.0 42.6 46.5 38.4 14.7 31.0 33.2 42.7 26.2 32.1 28.5 15.6 28.1 33.3 52.8 34.7 64.3 43.6 40.9 54.9 56.8 66.3 62.4 23.3 46.2 36.3 31.9 52.5 27.0 51.5 58.3 56.6 81.2 39.4 28.0 46.8 34.9 30.8 123.5 53.4 27.2 56.1 51.5 53.1 105.0 51.9 61.0 33.0 45.4 77.1 51.2 61.6 34.9 38.4 42.0 57.7 56.0 44.9 56.2 30.1 54.1 52.3 44.5 43.1 59.0 36.6 52.1 58.7 50.8 47.1 50.2 34.8 23.4 62.1 48.4 44.4 67.0 42.1 41.5 40.8 48.0 0.3 1.5 101.5 1.4 1.1 0.9 1.5 2.2 2.8 1.8 0.6 2.4 1.6 2.3 1.4 1.1 1.2 3.1 0.7 14.9 15.9 16.0 22.1 14.5 14.8 15.1 15.0 16.2 15.0 14.7 15.6 38.0 57.7 79.1 154.1 43.6 44.2 57.2 28.7 33.0 78.7 26.3 21.7 74.6 47.1 45.2 38.6 162.6 33.3 47.9 36.6 11.7 46.8 38.0 47.5 63.7 50.9 31.2 187.1 153.5 42.0 31.0 47.3 52.0 62.1 48.2 128.7 63.9 30.1 30.2 58.9 145.0 32.3 30.5 40.4 63.0 52.4 60.9 42.6 37.4 70.3 57.5 34.4 61.8 138.2 172.3 60.4 34.0 59.0 55.9 67.4 34.6 21.5 36.8 86.7 32.9 38.9 44.1 74.6 72.4 36.1 52.1 49.1 54.8 98.9 33.7 114.6 MARK4 "FLJ90097, KIAA1860, MARKL1, Nbla00650, PAR-1D" ENSG00000007047 "Microtubule affinity regulating kinase 4" Q96L34 19 45079288-45305284 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell cycle, Cell division, Cilium biogenesis/degradation, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Horizontal cells: 119.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039186 Approved Supported Cytosol NA NA "Cluster 10: Basophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 12: NES - Nervous system development" "Cluster 62: Horizontal cells - Visual perception" Cytosol "HPA039186: AB_10796223" "unprognostic (1.64e-1)" "unprognostic (1.95e-1)" "unprognostic (1.57e-3)" "prognostic unfavorable (8.31e-8)" "unprognostic (2.02e-1)" "prognostic unfavorable (3.05e-5)" "unprognostic (1.90e-1)" "unprognostic (2.16e-2)" "unprognostic (6.26e-2)" "unprognostic (5.64e-3)" "unprognostic (1.24e-3)" "unprognostic (7.50e-2)" "unprognostic (3.80e-2)" "unprognostic (6.89e-2)" "unprognostic (7.23e-2)" "unprognostic (4.65e-2)" "unprognostic (3.02e-2)" 13.1 13.5 27.5 7.2 31.4 8.5 13.0 16.1 37.7 17.1 11.3 16.5 5.0 15.5 16.6 16.4 14.8 10.6 17.3 31.6 19.6 13.5 21.8 13.9 8.3 24.0 25.2 21.7 14.0 20.5 16.6 11.6 22.6 16.2 5.8 26.0 12.7 13.0 38.7 26.9 9.1 14.6 14.1 11.4 14.3 40.4 29.9 13.1 12.7 12.0 9.6 19.0 16.7 26.1 20.3 7.7 36.6 23.8 25.3 36.8 8.8 15.3 25.1 21.8 20.8 4.0 10.8 8.5 12.0 28.9 20.6 13.5 26.4 22.5 14.2 15.7 16.0 20.7 8.5 17.0 47.6 4.4 15.1 48.1 31.9 18.7 22.8 43.3 29.5 22.1 22.6 21.8 24.9 14.4 16.7 14.5 12.3 18.6 4.7 61.5 11.4 6.3 23.4 16.0 58.8 27.1 20.5 17.5 12.5 35.9 9.0 29.3 21.6 16.7 12.9 12.2 9.0 22.7 21.8 10.8 17.9 8.4 12.7 1.1 1.0 0.2 1.0 0.7 0.2 0.2 0.3 1.3 0.3 0.2 0.6 0.7 0.9 0.7 0.7 0.9 0.8 0.4 27.5 31.4 16.1 37.7 31.6 19.6 24.0 25.2 22.6 14.1 29.9 26.1 8.7 12.8 3.1 30.7 6.0 25.0 11.3 7.2 15.4 20.9 10.2 7.0 9.1 11.5 4.4 9.2 25.0 4.3 8.1 3.7 11.7 8.4 2.3 6.6 9.5 12.2 6.1 6.1 31.1 6.1 1.5 8.4 10.2 10.5 2.5 18.9 18.5 10.7 7.0 119.5 36.5 4.7 4.1 9.5 11.0 6.3 16.1 8.2 3.6 16.9 5.9 19.6 12.3 23.1 16.4 9.5 3.5 13.9 7.7 13.0 4.7 6.5 2.5 15.6 0.0 7.6 8.4 1.2 8.3 12.5 24.2 11.5 10.3 26.1 3.2 15.5 MAST1 "KIAA0973, SAST" ENSG00000105613 "Microtubule associated serine/threonine kinase 1" Q9Y2H9 19 12833951-12874952 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 37.7;pituitary gland: 23.3;retina: 15.4" "Cell type enhanced" "Detected in many" "Bipolar cells: 24.7;Cone photoreceptor cells: 43.8;Excitatory neurons: 64.7;Inhibitory neurons: 70.3;Oligodendrocyte precursor cells: 22.1;Rod photoreceptor cells: 20.4" "Cancer enhanced" "Detected in many" "glioma: 3.5" "Region enhanced" "Detected in many" "cerebral cortex: 37.7" "Immune cell enhanced" "Detected in single" "MAIT T-cell: 1.0" "Lineage enriched" "Detected in single" 9 "T-cells: 1.0" "Cell line enhanced" "Detected in many" "AN3-CA: 23.3;SCLC-21H: 40.5;SH-SY5Y: 20.2;U-266/70: 16.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028181, HPA073106" Enhanced Supported Vesicles,Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 58: Brain - Synaptic function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles Cytosol "HPA028181: AB_10603872, HPA073106: AB_2732218" "unprognostic (6.32e-2)" "unprognostic (3.66e-2)" "unprognostic (3.93e-2)" "unprognostic (2.83e-5)" "unprognostic (1.72e-1)" "unprognostic (4.19e-2)" "unprognostic (2.38e-1)" "unprognostic (8.72e-2)" "unprognostic (1.04e-1)" "unprognostic (3.64e-1)" "unprognostic (8.89e-3)" "unprognostic (3.43e-2)" "unprognostic (3.84e-3)" "unprognostic (1.19e-1)" "unprognostic (7.04e-2)" "unprognostic (2.49e-2)" "unprognostic (1.96e-1)" 0.0 2.2 6.5 0.3 12.1 0.3 0.1 7.3 37.7 0.2 0.0 1.2 0.3 0.0 0.0 0.2 0.1 0.2 0.2 8.3 2.4 0.1 0.6 0.1 0.1 11.2 1.1 0.3 0.6 0.5 23.3 0.0 9.5 0.2 0.1 15.4 0.2 0.0 0.0 3.7 0.4 0.0 0.0 0.1 0.6 5.0 1.2 0.8 0.1 0.0 0.0 0.2 0.3 3.0 3.6 1.6 1.5 23.3 0.0 0.0 1.9 0.2 0.1 0.3 0.9 0.8 1.5 5.8 2.6 0.0 3.9 0.1 6.8 0.1 0.1 4.1 4.5 0.5 5.8 2.6 0.0 1.3 1.2 0.5 0.1 0.8 0.7 1.3 0.0 15.2 5.2 3.0 0.0 0.8 2.4 0.6 6.9 0.6 7.2 15.9 4.6 8.3 0.3 0.2 40.5 20.2 0.8 1.4 4.3 1.2 3.8 2.1 0.0 2.8 4.2 3.1 0.8 16.7 14.5 3.7 5.1 3.1 0.1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.6 0.0 6.5 12.1 7.3 37.7 8.3 2.4 11.2 1.1 9.5 0.0 1.2 3.0 0.5 0.0 2.4 7.8 0.2 0.9 1.6 0.6 0.6 24.7 0.8 2.5 1.0 0.0 0.3 0.0 43.8 0.6 0.4 0.6 0.0 0.4 14.0 0.2 0.2 1.3 0.0 0.0 64.7 0.5 0.6 1.3 0.0 0.3 1.3 0.5 1.1 0.5 0.2 15.2 70.3 0.1 0.0 1.0 1.2 8.2 0.6 0.7 5.4 6.5 0.1 3.7 0.0 22.1 3.0 0.3 2.5 1.2 0.0 1.0 0.9 0.2 1.0 20.4 0.0 2.0 0.5 8.0 5.2 0.7 1.4 0.3 1.0 0.4 0.7 1.2 MAST2 "KIAA0807, MAST205" ENSG00000086015 "Microtubule associated serine/threonine kinase 2" Q6P0Q8 1 45786987-46036122 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 170.6" "Cell type enhanced" "Detected in many" "Distal enterocytes: 66.9;Inhibitory neurons: 86.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "non-classical monocyte: 1.5" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039722, HPA040155" Approved Approved Cytosol NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "HPA039722: AB_10795294, HPA040155: AB_10793957" "unprognostic (7.80e-2)" "unprognostic (3.02e-2)" "unprognostic (5.77e-2)" "unprognostic (1.52e-1)" "unprognostic (3.82e-1)" "unprognostic (3.17e-2)" "prognostic unfavorable (4.31e-8)" "unprognostic (8.86e-2)" "unprognostic (2.34e-2)" "unprognostic (1.98e-1)" "unprognostic (1.60e-1)" "unprognostic (1.75e-1)" "prognostic unfavorable (6.85e-13)" "unprognostic (4.82e-3)" "unprognostic (2.43e-1)" "unprognostic (9.73e-2)" "unprognostic (4.90e-1)" 18.3 11.8 16.2 11.0 15.5 8.0 18.7 15.4 17.5 57.4 7.3 39.1 21.9 43.5 12.8 14.7 31.2 19.0 65.3 15.2 19.4 12.2 18.9 17.8 8.9 19.7 27.7 51.9 9.2 13.9 27.0 8.6 26.4 40.0 25.3 24.0 18.4 15.4 170.6 14.6 30.7 26.3 14.6 7.2 24.0 56.3 18.3 5.8 13.2 73.1 11.1 46.9 28.8 15.7 31.7 25.1 24.7 19.2 30.7 41.4 27.6 32.2 22.8 29.4 32.6 29.4 10.1 48.8 15.2 38.6 59.9 15.7 30.1 18.8 30.4 23.7 16.4 22.2 29.2 27.4 28.4 12.0 27.3 34.1 23.7 49.8 37.0 35.2 27.5 12.5 17.3 14.6 34.2 21.9 17.7 12.5 20.4 21.2 28.2 25.6 40.7 9.4 16.1 16.8 34.0 20.6 38.0 50.4 16.3 26.9 22.8 11.9 27.9 55.7 36.8 30.1 33.0 19.5 18.9 17.5 38.0 16.0 24.2 0.0 0.3 0.4 0.3 0.2 0.4 0.0 0.2 0.4 0.6 0.1 0.1 0.2 0.0 0.5 1.5 0.0 0.0 0.2 16.2 15.5 15.4 17.5 15.2 19.4 19.7 27.7 26.4 14.6 18.3 15.7 5.5 0.0 2.0 32.0 2.3 4.2 4.1 3.0 8.0 15.8 8.2 6.7 46.5 4.3 5.5 3.7 54.2 6.1 2.4 66.9 1.9 4.6 38.0 4.4 17.0 7.3 12.1 6.5 45.4 6.3 4.8 12.0 12.8 7.8 0.0 13.0 3.6 6.6 6.2 5.0 86.6 24.6 0.0 2.8 7.8 57.7 9.0 5.3 7.2 30.9 2.5 3.7 7.2 52.3 52.5 8.3 33.9 10.1 5.5 10.7 50.2 5.7 3.1 12.8 6.6 11.7 9.0 28.0 13.2 6.3 2.7 5.5 3.5 12.4 22.4 7.4 MAST3 KIAA0561 ENSG00000099308 "Microtubule associated serine/threonine kinase 3" O60307 19 18097793-18151692 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 62.1" "Cell type enhanced" "Detected in many" "Excitatory neurons: 62.6;Oligodendrocytes: 63.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035061, HPA035062" Uncertain Approved "Nuclear speckles" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 10: Brain - Neuronal signaling" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nuclear speckles" "HPA035061: AB_10670585, HPA035062: AB_10671508" "unprognostic (5.94e-3)" "unprognostic (4.75e-2)" "unprognostic (1.70e-1)" "unprognostic (1.02e-1)" "unprognostic (3.38e-1)" "prognostic favorable (2.97e-4)" "unprognostic (1.93e-1)" "unprognostic (4.63e-2)" "unprognostic (1.43e-1)" "unprognostic (3.21e-1)" "prognostic favorable (7.01e-4)" "unprognostic (2.58e-1)" "unprognostic (1.64e-3)" "unprognostic (1.02e-2)" "unprognostic (3.61e-1)" "unprognostic (1.58e-3)" "unprognostic (1.26e-3)" 4.9 4.8 49.9 9.2 53.4 14.4 3.7 0.0 62.1 9.4 0.0 7.3 9.6 5.3 4.7 3.3 7.1 3.1 3.7 61.6 0.0 7.6 14.5 9.1 11.2 5.3 1.9 7.1 20.2 5.0 15.5 2.6 4.3 5.6 4.3 1.0 4.8 3.9 3.0 7.3 12.4 3.0 0.0 19.2 4.5 3.6 13.7 4.2 4.5 1.6 10.1 3.7 4.9 47.4 3.5 5.1 2.3 10.2 6.7 5.4 5.5 3.5 2.2 2.4 3.4 5.2 4.7 9.0 5.1 3.5 2.6 1.9 3.4 2.0 1.7 7.7 4.2 4.1 5.7 8.3 5.6 2.2 13.2 6.2 5.7 3.6 1.4 3.2 1.1 6.1 4.3 5.8 2.8 6.3 4.7 7.3 2.4 7.7 6.2 12.6 2.0 6.6 1.9 1.5 3.8 6.2 4.9 2.8 2.1 1.6 3.2 5.1 4.0 3.0 3.2 13.1 1.5 6.2 9.0 8.0 6.7 11.6 2.9 0.3 6.2 14.8 11.7 8.0 8.4 5.9 6.3 4.7 3.2 5.9 4.9 8.4 32.9 8.1 14.7 15.4 7.6 6.1 49.9 53.4 0.0 62.1 61.6 0.0 5.3 1.9 4.3 0.0 13.7 47.4 2.6 6.4 9.4 5.5 13.5 0.5 0.8 2.8 2.8 3.0 2.6 2.8 1.5 7.2 3.6 9.2 2.1 0.5 19.0 30.0 3.9 2.9 9.3 2.8 5.4 3.8 2.4 1.3 62.6 10.5 1.5 3.4 7.7 1.5 2.5 3.0 4.6 16.3 7.7 0.0 6.1 8.5 0.0 21.7 6.3 30.8 4.1 13.3 5.4 19.7 19.6 0.9 32.0 8.0 63.7 7.1 7.9 6.8 5.1 1.2 16.7 8.8 4.2 0.7 0.0 2.1 3.0 0.6 3.9 2.3 2.3 0.4 11.0 5.3 13.0 0.6 MAST4 KIAA0303 ENSG00000069020 "Microtubule associated serine/threonine kinase family member 4" O15021 5 66596361-67169595 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Astrocytes: 519.7;Basal prostatic cells: 507.3;Excitatory neurons: 636.6;Inhibitory neurons: 489.6;Suprabasal keratinocytes: 399.2;Urothelial cells: 676.4" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "cerebral cortex: 27.7" "Immune cell enhanced" "Detected in many" "basophil: 15.2" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HBEC3-KT: 33.2;HDLM-2: 43.2;HEL: 35.5;RT4: 42.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000544 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 46: Fibroblasts - ECM organization" "Cluster 36: HEL - Hemostasis" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Cytosol" "HPA000544: AB_1079315" "unprognostic (1.77e-2)" "unprognostic (6.24e-2)" "unprognostic (1.80e-1)" "unprognostic (4.99e-3)" "unprognostic (2.83e-2)" "prognostic favorable (5.18e-5)" "unprognostic (9.01e-2)" "unprognostic (1.00e-1)" "unprognostic (2.79e-2)" "unprognostic (9.47e-2)" "unprognostic (5.03e-2)" "unprognostic (3.01e-2)" "unprognostic (1.01e-2)" "unprognostic (1.37e-2)" "unprognostic (2.63e-1)" "unprognostic (2.63e-1)" "unprognostic (3.08e-2)" 14.9 11.0 4.6 4.5 5.2 1.9 11.1 0.9 27.7 12.1 0.0 6.0 5.1 10.0 5.0 27.0 9.4 8.0 29.5 4.2 5.4 12.0 8.4 11.0 4.4 5.0 5.5 16.4 4.6 15.3 4.6 8.8 1.2 7.6 4.1 4.7 11.5 6.6 11.2 14.8 4.5 9.3 1.1 5.0 7.0 10.0 3.3 16.8 6.5 7.2 10.1 16.0 21.2 11.4 14.6 7.8 3.8 0.2 12.4 10.9 9.0 3.2 4.9 1.1 1.0 7.3 3.9 1.0 6.5 2.7 2.9 12.8 11.8 33.2 1.3 43.2 3.8 35.5 4.7 3.1 0.9 0.1 11.9 18.4 17.8 7.1 14.2 13.3 26.2 3.2 3.5 3.9 8.9 12.6 5.1 0.2 2.5 1.2 6.3 1.1 3.3 0.7 3.1 42.9 5.5 4.4 4.3 1.7 0.2 2.7 2.8 0.2 25.2 3.0 4.1 4.6 5.4 9.9 4.8 0.2 7.7 0.1 2.4 15.2 0.3 0.8 0.9 0.4 2.5 2.9 4.0 1.0 0.4 2.5 4.2 1.8 3.5 2.3 0.9 1.0 6.9 1.3 4.6 5.2 0.9 27.7 4.2 5.4 5.0 5.5 1.2 1.1 3.3 11.4 130.2 32.1 53.3 519.7 11.4 368.6 507.3 127.9 114.9 15.9 79.3 38.1 139.1 27.1 78.7 18.4 2.1 40.7 4.9 24.4 37.2 59.0 129.2 35.8 5.3 111.8 32.2 5.5 636.6 115.8 50.0 33.2 28.5 55.3 93.8 19.4 70.6 42.2 5.1 8.4 489.6 18.1 40.7 6.9 33.7 127.4 41.3 9.8 48.0 78.7 2.1 55.2 4.1 165.9 108.4 70.8 27.2 32.7 13.5 355.5 14.8 93.9 57.2 4.5 39.5 15.9 31.1 14.8 9.2 211.7 399.2 137.2 21.0 14.7 16.1 676.4 MASTL "FLJ14813, Gwl, THC2" ENSG00000120539 "Microtubule associated serine/threonine kinase like" Q96GX5 10 27154824-27187953 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 24.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Not detected" "Not detected" "Not detected" "Not detected" "HPA027175, HPA054273" Approved Enhanced Nucleoplasm NA Yes "Cluster 8: Neutrophils - Inflammatory response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "HPA027175: AB_1853591, HPA054273: AB_2682433" "unprognostic (4.10e-2)" "unprognostic (6.89e-2)" "unprognostic (1.22e-2)" "unprognostic (3.14e-3)" "unprognostic (3.67e-1)" "unprognostic (1.97e-2)" "prognostic unfavorable (2.52e-6)" "unprognostic (2.19e-2)" "unprognostic (4.00e-2)" "unprognostic (4.05e-2)" "prognostic unfavorable (4.81e-5)" "unprognostic (3.78e-2)" "prognostic unfavorable (1.71e-6)" "unprognostic (1.55e-3)" "unprognostic (2.27e-1)" "unprognostic (2.66e-1)" "unprognostic (1.79e-1)" 5.0 3.9 1.7 6.2 1.9 18.7 5.3 2.3 2.3 3.8 2.1 4.1 4.4 3.9 4.5 5.9 3.0 3.9 2.5 1.9 2.0 3.9 4.9 4.0 8.9 2.0 2.0 3.4 3.3 6.0 3.1 6.5 2.1 3.1 5.2 2.7 4.1 3.0 2.3 6.0 4.3 4.5 1.6 4.6 4.7 6.5 2.0 10.4 4.7 2.2 7.1 4.5 4.3 2.3 29.4 22.0 43.8 15.5 6.2 9.1 25.4 43.3 18.0 68.4 83.8 26.7 27.2 22.4 16.1 18.4 33.5 26.8 27.9 16.0 48.2 20.2 26.5 26.9 14.5 15.5 3.8 10.4 19.8 5.6 7.5 41.6 7.9 9.0 14.7 18.2 21.1 49.9 41.5 17.9 34.8 11.2 32.0 15.9 8.9 22.2 71.9 18.9 17.4 10.6 19.2 26.8 26.0 17.6 19.1 28.1 17.2 21.4 12.6 17.0 36.3 44.0 37.4 5.9 10.3 34.7 18.3 31.1 14.8 0.2 1.8 1.7 0.7 1.7 1.1 1.1 0.9 0.7 1.0 1.6 0.9 0.8 2.3 1.0 1.8 1.1 1.6 0.8 1.7 1.9 2.3 2.3 1.9 2.0 2.0 2.0 2.1 1.6 2.0 2.3 4.3 6.4 7.8 2.6 7.4 11.0 4.9 4.4 4.0 1.7 4.2 4.8 3.0 2.8 7.0 1.8 0.0 8.6 10.1 7.0 0.0 4.0 3.0 9.7 5.3 4.6 4.2 7.8 4.3 2.5 24.9 7.3 6.1 17.9 12.7 6.9 2.5 2.5 5.8 3.3 4.3 3.7 4.1 7.8 19.3 1.7 3.1 11.3 0.0 3.7 5.1 1.8 3.1 3.5 4.9 4.4 2.9 2.6 7.1 5.0 2.8 1.9 4.0 1.0 0.0 3.8 5.3 14.9 14.1 10.9 9.9 6.2 11.6 5.4 4.5 6.6 MDM2 "HDM2, MGC5370" ENSG00000135679 "MDM2 proto-oncogene" Q00987 12 68808177-68850686 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Ubl conjugation pathway" Transferase "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Endometrial ciliated cells: 257.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HBEC3-KT: 504.6;U-698: 517.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000086, CAB016303, CAB079977" Supported Supported "Nucleoplasm,Golgi apparatus,Cytosol" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 49: Ciliated cells - Cilium organization" "Nucleoplasm, Cytosol" "Golgi apparatus" "CAB000086: AB_563872, CAB016303: AB_627920, CAB079977: " "unprognostic (1.16e-1)" "prognostic favorable (3.23e-4)" "unprognostic (6.16e-2)" "prognostic favorable (4.51e-7)" "unprognostic (7.25e-2)" "unprognostic (6.91e-2)" "unprognostic (3.77e-2)" "unprognostic (1.72e-1)" "unprognostic (2.45e-2)" "unprognostic (3.23e-1)" "unprognostic (1.80e-3)" "unprognostic (2.36e-1)" "unprognostic (4.22e-2)" "unprognostic (4.59e-2)" "unprognostic (1.81e-1)" "unprognostic (2.68e-1)" "unprognostic (8.95e-2)" 14.0 11.6 5.4 10.4 10.0 28.6 11.9 7.4 7.6 13.9 28.0 20.7 6.4 9.5 7.1 13.0 14.1 12.0 6.8 3.8 7.4 9.5 26.9 14.3 13.8 9.9 8.5 10.8 14.3 10.9 5.0 16.4 9.2 11.3 21.9 14.2 9.6 11.5 18.6 10.9 7.5 12.4 6.0 11.4 10.0 6.6 9.2 15.6 15.4 12.9 17.0 15.1 10.8 12.8 18.7 42.1 43.5 22.6 55.9 51.5 223.4 49.7 50.3 26.2 41.5 26.8 8.4 188.6 13.5 34.7 7.3 11.0 31.4 504.6 42.1 51.0 22.0 35.3 36.0 115.0 55.7 32.6 31.0 77.8 46.5 101.5 69.4 26.9 73.7 32.1 37.1 45.4 50.8 28.0 43.1 10.7 36.9 10.1 8.2 149.4 31.7 16.2 16.0 146.0 34.3 20.2 32.0 25.0 11.3 88.8 58.3 21.4 82.3 20.2 38.0 16.8 18.5 68.2 47.7 517.6 31.3 12.8 81.2 6.1 5.4 5.2 4.1 4.1 3.7 4.7 3.5 4.1 3.0 5.4 3.6 3.5 19.2 3.7 7.2 3.9 4.1 3.6 5.4 10.0 7.4 7.6 3.8 7.4 9.9 8.5 9.2 6.0 9.2 12.8 23.1 32.1 56.3 26.1 36.4 15.6 30.5 42.6 22.8 26.8 21.4 17.1 20.9 24.3 75.8 25.8 33.3 47.5 32.1 19.3 13.7 19.5 2.5 257.4 34.5 22.0 25.1 29.9 28.8 24.2 28.0 31.9 28.5 74.8 32.9 33.2 15.7 45.0 18.3 30.3 32.9 23.4 32.6 49.0 25.0 2.9 19.3 44.9 12.4 37.5 35.4 27.8 10.3 25.6 71.8 22.4 20.1 15.1 117.7 39.8 15.8 21.3 141.7 35.3 19.7 30.0 32.4 17.3 20.0 59.5 22.0 94.3 31.8 49.4 20.9 82.0 MED1 "CRSP1, CRSP200, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2" ENSG00000125686 "Mediator complex subunit 1" Q15648 17 39404285-39451272 "Cancer-related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, DNA-binding" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SK-BR-3: 206.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017696, HPA052818" Approved Supported Nucleoplasm NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "CAB017696: AB_1128703, HPA052818: AB_2681962" "unprognostic (1.77e-1)" "unprognostic (1.63e-1)" "unprognostic (9.26e-2)" "unprognostic (1.21e-1)" "unprognostic (2.18e-2)" "unprognostic (1.67e-1)" "unprognostic (1.21e-2)" "unprognostic (4.50e-1)" "unprognostic (7.86e-2)" "unprognostic (1.95e-3)" "unprognostic (4.09e-2)" "unprognostic (1.04e-1)" "unprognostic (1.78e-2)" "unprognostic (2.00e-1)" "unprognostic (5.94e-2)" "unprognostic (9.40e-2)" "unprognostic (5.79e-2)" 10.3 8.7 7.2 11.3 7.7 12.9 10.6 8.5 8.2 9.7 7.4 10.6 7.7 11.0 5.9 9.8 9.3 7.6 9.6 6.9 7.4 8.8 9.0 8.7 13.3 7.2 7.3 11.3 7.9 16.8 6.0 10.4 7.5 8.3 9.5 8.0 8.6 7.7 13.7 11.1 9.7 11.2 7.4 11.2 8.6 10.7 7.7 16.9 9.1 12.2 14.7 10.9 9.1 8.8 20.1 24.5 32.5 22.7 23.1 23.7 25.8 24.0 25.6 30.6 30.1 24.9 20.1 51.4 26.2 28.9 37.2 38.3 38.0 22.9 50.0 49.2 31.8 32.3 24.1 24.0 24.4 59.8 33.9 22.1 23.6 39.3 55.0 20.1 28.1 30.6 42.1 28.4 25.7 10.7 56.5 23.2 20.9 19.4 15.1 41.3 43.1 22.9 18.5 22.4 20.3 23.2 30.9 206.2 27.6 28.0 38.5 33.4 23.7 24.8 31.1 28.1 42.3 25.3 36.4 53.6 24.3 28.4 32.0 1.3 1.4 1.8 1.6 1.4 1.9 2.2 1.8 1.8 1.5 2.0 1.8 2.1 1.2 1.9 0.8 1.5 1.5 1.0 7.2 7.7 8.5 8.2 6.9 7.4 7.2 7.3 7.5 7.4 7.7 8.8 18.8 25.6 13.9 10.1 24.7 27.1 14.2 13.1 19.4 13.7 18.0 13.8 18.9 12.8 21.0 9.2 14.6 17.2 20.6 12.7 3.9 12.3 7.9 19.0 27.1 21.2 13.8 26.9 13.4 12.0 12.8 19.7 10.7 27.0 9.5 19.9 17.2 20.2 14.9 11.8 13.9 14.8 16.2 20.0 16.5 7.7 14.6 16.4 21.4 11.2 21.0 13.5 17.5 11.1 16.0 13.7 12.1 18.0 20.2 19.9 9.4 8.5 17.4 12.0 19.7 26.1 21.2 22.3 17.0 21.7 32.7 22.2 22.8 18.7 15.0 18.7 MELK KIAA0175 ENSG00000165304 "Maternal embryonic leucine zipper kinase" Q14680 9 36572862-36677683 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 10.0;lymphoid tissue: 21.0" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 16.1;Erythroid cells: 15.2;Extravillous trophoblasts: 44.1;Spermatocytes: 23.2;Spermatogonia: 21.3" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 4 "T-reg: 1.7" "Lineage enriched" "Detected in single" 4 "T-cells: 1.7" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" HPA017214 Uncertain NA Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 12: Non-specific - Cell cycle regulation" "HPA017214: AB_1853798" "unprognostic (5.03e-2)" "unprognostic (9.57e-2)" "unprognostic (2.27e-2)" "unprognostic (3.42e-3)" "unprognostic (2.16e-1)" "unprognostic (1.23e-1)" "prognostic unfavorable (2.91e-7)" "prognostic unfavorable (3.99e-4)" "unprognostic (1.26e-2)" "unprognostic (1.60e-2)" "prognostic unfavorable (4.58e-4)" "unprognostic (4.69e-2)" "prognostic unfavorable (0.00e+0)" "unprognostic (8.86e-3)" "unprognostic (1.37e-1)" "unprognostic (2.40e-1)" "unprognostic (1.35e-1)" 0.9 0.5 0.0 5.7 0.0 10.0 1.4 0.0 0.1 1.3 0.0 6.8 5.2 1.0 0.0 7.9 0.3 0.6 0.2 0.0 0.0 0.3 0.7 0.9 10.0 0.0 0.1 0.2 0.3 0.1 0.0 5.3 0.1 0.3 8.5 0.0 1.2 0.1 0.0 3.4 4.4 2.4 0.0 2.0 3.2 9.2 0.3 21.0 0.3 0.1 11.7 1.7 2.3 0.0 123.4 62.1 81.6 48.5 11.1 18.8 47.1 88.8 62.2 121.5 148.2 47.8 47.3 40.9 27.8 43.8 106.5 41.0 71.7 55.5 133.1 112.3 28.6 32.0 69.1 48.1 4.3 50.2 39.0 6.9 9.8 93.9 53.0 15.6 62.2 61.9 41.7 63.2 100.9 40.9 63.1 23.4 65.1 55.1 47.9 57.4 54.9 25.8 37.7 40.7 55.1 40.8 47.4 45.3 28.6 45.2 38.0 23.7 30.8 65.4 81.8 56.1 82.3 12.3 47.9 60.7 41.2 36.8 91.3 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.2 1.7 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.7 1.9 4.6 0.9 3.5 0.0 0.0 0.9 0.8 0.4 0.0 2.0 0.0 0.0 16.1 0.7 4.5 0.0 1.1 2.8 2.9 1.4 1.3 0.0 15.2 0.8 1.1 44.1 3.3 4.6 2.1 0.0 7.8 1.4 0.7 10.1 0.0 0.7 4.7 4.1 1.6 3.0 2.7 1.2 1.9 0.0 0.0 3.1 0.0 2.1 1.0 0.4 1.7 2.7 0.0 10.2 0.5 0.6 0.1 2.0 0.0 0.0 0.0 3.7 23.2 21.3 9.3 1.7 8.9 2.7 0.7 8.9 2.3 METTL1 "C12orf1, TRM8, TRMT8" ENSG00000037897 "Methyltransferase like 1" Q9UBP6 12 57768471-57772119 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "tRNA processing" "Methyltransferase, RNA-binding, Transferase, tRNA-binding" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Proximal tubular cells: 60.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 6 "RH-30: 293.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020914, HPA050450" Uncertain Supported Nucleoplasm NA NA "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "HPA020914: AB_1853830, HPA050450: AB_2681130" "unprognostic (5.24e-2)" "unprognostic (2.60e-1)" "unprognostic (9.43e-2)" "unprognostic (3.46e-1)" "unprognostic (9.01e-2)" "unprognostic (1.41e-2)" "prognostic unfavorable (4.25e-6)" "unprognostic (5.67e-2)" "unprognostic (6.19e-2)" "unprognostic (1.14e-3)" "unprognostic (1.78e-1)" "unprognostic (2.32e-1)" "prognostic unfavorable (3.55e-6)" "unprognostic (7.75e-2)" "unprognostic (1.96e-1)" "unprognostic (5.01e-2)" "unprognostic (2.22e-1)" 13.6 23.2 8.9 9.8 9.2 11.0 12.8 8.7 11.9 9.8 9.9 8.4 4.0 10.8 20.8 13.1 10.2 5.5 10.3 9.2 9.4 22.0 17.5 9.3 8.1 9.2 9.3 11.3 28.0 9.1 12.7 8.7 9.0 13.4 10.8 3.7 10.6 7.1 15.5 11.7 6.9 12.3 8.9 9.0 9.8 9.9 9.6 4.8 14.3 6.9 9.3 16.5 9.4 9.0 24.7 44.1 17.7 14.9 22.6 15.7 23.4 24.8 23.1 41.9 24.7 32.0 32.6 28.8 45.7 33.0 23.1 27.9 27.4 39.8 38.0 17.2 32.6 34.9 17.4 35.0 17.9 39.0 17.4 14.7 32.7 47.8 33.5 18.9 22.2 17.8 34.1 28.2 23.1 47.0 26.1 39.6 40.6 29.1 41.5 23.0 293.1 43.1 33.6 29.8 18.7 16.2 26.9 29.6 22.9 16.0 38.5 32.0 17.1 17.4 18.0 29.6 34.0 13.2 9.3 32.6 24.4 25.3 34.5 0.0 7.1 0.0 8.0 10.8 27.4 6.9 10.0 9.6 16.3 10.5 13.4 13.2 1.1 12.9 1.8 19.3 5.1 7.5 8.9 9.2 8.7 11.9 9.2 9.4 9.2 9.3 9.0 8.9 9.6 9.0 6.3 9.6 3.3 0.7 8.3 10.5 17.1 14.8 13.6 3.7 12.2 12.4 4.3 10.0 14.1 5.5 0.0 18.7 3.1 6.3 25.4 16.8 12.1 5.3 13.2 8.2 6.6 6.3 0.8 24.1 25.3 11.3 10.2 8.9 12.7 8.7 3.3 7.9 22.7 3.3 0.6 8.4 12.2 2.2 9.8 10.9 11.1 6.4 7.2 0.0 16.7 2.6 3.1 3.5 1.1 12.3 2.3 4.9 14.9 15.4 1.1 60.4 2.6 5.4 0.0 9.7 13.0 8.0 17.7 12.1 10.4 9.7 4.1 14.0 10.7 11.3 METTL3 "M6A, MT-A70, Spo8" ENSG00000165819 "Methyltransferase like 3" Q86U44 14 21498133-21511342 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Biological rhythms, Differentiation, DNA damage, Immunity, Innate immunity, Oogenesis, Spermatogenesis" "Methyltransferase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in all" 4 "Early spermatids: 188.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 23: Testis - Cell cycle regulation" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 23: Spermatids - Flagellum & Golgi organization" "unprognostic (1.62e-1)" "unprognostic (1.65e-1)" "unprognostic (5.75e-2)" "unprognostic (1.70e-1)" "unprognostic (1.22e-1)" "unprognostic (1.01e-1)" "prognostic unfavorable (2.19e-5)" "unprognostic (1.02e-3)" "unprognostic (1.85e-1)" "prognostic favorable (2.78e-4)" "prognostic favorable (2.72e-4)" "unprognostic (4.52e-2)" "unprognostic (4.64e-3)" "unprognostic (2.98e-2)" "unprognostic (7.14e-2)" "unprognostic (5.36e-2)" "unprognostic (1.22e-1)" 12.1 18.5 12.1 11.3 13.0 5.8 16.0 12.6 13.1 12.9 12.5 11.9 7.6 13.2 18.1 11.7 18.8 9.8 16.7 12.5 12.9 14.1 11.7 12.9 19.0 14.1 13.1 15.0 11.5 19.0 13.0 15.2 13.7 17.3 12.9 8.6 14.2 16.7 16.8 16.5 10.6 16.3 13.1 13.9 11.2 19.8 13.4 17.8 16.8 18.6 21.2 14.4 12.4 13.7 39.6 57.7 55.0 22.2 40.5 33.4 27.5 35.9 26.0 41.7 48.5 22.0 46.4 40.8 22.6 22.3 54.2 41.6 66.4 35.2 65.7 39.1 39.8 25.9 31.9 88.1 16.6 34.8 28.2 25.0 30.3 26.0 30.2 18.6 54.8 20.8 32.0 23.5 55.9 29.1 31.0 28.6 46.4 66.1 70.7 30.7 42.6 36.5 38.8 26.6 33.4 36.6 38.7 50.6 37.5 42.7 39.8 22.8 36.6 15.0 24.8 27.6 24.9 24.9 32.5 29.0 18.2 27.7 32.0 6.5 8.9 8.9 8.0 11.5 12.4 14.3 10.0 9.4 10.9 10.8 10.3 9.3 0.9 15.7 9.6 13.0 15.5 8.4 12.1 13.0 12.6 13.1 12.5 12.9 14.1 13.1 13.7 13.1 13.4 13.7 12.5 12.8 20.1 15.7 16.2 14.9 23.3 21.2 21.1 23.4 15.1 16.5 30.6 12.8 13.6 12.9 14.6 31.1 16.2 5.4 3.9 14.5 188.2 11.7 11.4 14.7 10.8 20.4 15.0 10.0 15.7 15.3 7.1 10.0 8.8 20.4 9.7 9.5 16.6 21.9 13.7 8.7 14.2 10.0 9.9 24.3 17.1 10.8 16.0 10.3 17.9 14.9 15.5 19.1 21.7 10.8 6.5 19.9 14.9 18.8 5.5 9.1 15.3 21.0 32.9 16.4 17.5 42.4 20.3 12.4 12.4 25.3 13.2 13.2 13.4 19.0 MGAM MGA ENSG00000257335 Maltase-glucoamylase O43451 7 141907813-142106747 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Glycosidase, Hydrolase, Multifunctional enzyme" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "epididymis: 25.5;intestine: 87.6" "Group enriched" "Detected in some" 5 "Late spermatids: 156.4;Proximal enterocytes: 521.4" "Cancer enriched" "Detected in some" 7 "renal cancer: 4.9" "Region enhanced" "Detected in single" "cerebral cortex: 2.3" "Immune cell enriched" "Detected in some" 7 "neutrophil: 13.5" "Lineage enriched" "Detected in single" 102 "granulocytes: 13.5" "Cell line enhanced" "Detected in some" "A549: 1.8;BJ hTERT+: 1.6;HL-60: 2.8;U-937: 4.3;WM-115: 1.0" "Region enriched" "Detected in single" 12 "olfactory bulb: 2.0" "Low region specificity" "Detected in many" HPA002270 Enhanced NA NA 310000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 32: U-937 - Innate immune response" "Cluster 45: Enterocytes - Digestion" "HPA002270: AB_1079366" "unprognostic (1.02e-2)" "unprognostic (1.45e-1)" "unprognostic (1.13e-1)" "unprognostic (6.95e-3)" "unprognostic (2.80e-1)" "unprognostic (7.81e-2)" "unprognostic (7.32e-3)" "unprognostic (3.83e-2)" "unprognostic (4.97e-1)" "unprognostic (2.17e-2)" "unprognostic (6.86e-2)" "unprognostic (1.99e-1)" "prognostic favorable (6.16e-5)" "unprognostic (1.82e-1)" "unprognostic (2.82e-1)" "unprognostic (1.34e-3)" "unprognostic (3.03e-1)" 2.6 0.1 0.2 2.5 0.4 18.1 0.2 0.2 2.3 0.4 0.3 0.5 58.9 0.1 25.5 0.3 1.2 0.4 0.3 0.1 0.3 18.7 0.5 3.2 0.1 0.5 0.4 0.1 0.2 0.0 0.1 0.3 0.6 0.1 0.2 0.0 0.1 7.1 0.1 0.1 87.6 0.4 0.2 12.6 1.8 1.3 0.6 0.4 0.1 1.0 0.0 0.5 0.1 0.4 0.0 1.8 0.1 0.0 0.0 0.0 0.2 0.0 1.6 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.2 0.0 0.1 0.0 0.0 0.0 4.3 1.0 0.0 0.1 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.5 0.0 0.0 0.0 0.0 0.0 0.2 0.4 0.2 2.3 0.1 0.3 0.5 0.4 0.6 0.2 0.6 0.4 0.0 0.0 2.5 3.3 0.1 0.0 0.0 0.6 0.0 0.2 0.5 0.1 1.4 0.0 3.2 12.9 0.0 0.0 2.8 1.8 1.9 0.1 59.7 0.1 0.2 0.3 1.2 0.0 0.7 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.3 0.2 0.0 0.7 17.8 0.0 0.0 2.5 156.4 0.6 1.1 0.0 0.0 0.7 0.6 5.2 1.5 0.6 0.2 16.3 0.4 0.0 0.1 521.4 24.4 6.7 0.0 0.0 0.5 0.1 1.8 1.2 0.0 0.0 0.0 0.4 0.0 7.3 0.3 MGMT ENSG00000170430 "O-6-methylguanine-DNA methyltransferase" P16455 10 129467190-129770983 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair" "DNA-binding, Methyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 89.3" "Cell type enhanced" "Detected in all" "Hepatocytes: 465.7;Proximal tubular cells: 340.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "MCF7: 60.0" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "CAB002786, HPA032135, HPA032136, HPA069497, CAB069881" Supported Enhanced Nucleoplasm NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 85: Liver - Metabolism" "Cluster 39: CACO-2 - Unknown function" "Cluster 2: Hepatocytes - Metabolism" Nucleoplasm "CAB002786: , CAB069881: AB_10002128, HPA032135: AB_2674171, HPA032136: AB_2674172, HPA069497: AB_2732134" "unprognostic (1.10e-1)" "prognostic favorable (9.42e-4)" "unprognostic (1.48e-1)" "unprognostic (5.81e-2)" "unprognostic (7.84e-3)" "unprognostic (1.67e-1)" "prognostic favorable (1.54e-4)" "unprognostic (6.54e-3)" "unprognostic (4.71e-2)" "unprognostic (2.03e-1)" "unprognostic (1.26e-1)" "unprognostic (6.32e-1)" "unprognostic (4.89e-1)" "unprognostic (2.75e-1)" "unprognostic (1.95e-1)" "unprognostic (1.66e-1)" "unprognostic (1.08e-1)" 21.5 17.0 14.7 10.3 15.1 12.7 20.4 14.8 18.6 13.9 16.6 14.7 16.9 13.3 8.1 15.9 23.7 19.6 18.5 14.1 14.5 23.5 89.3 11.7 19.4 15.9 15.4 16.9 26.5 12.3 9.5 6.8 16.0 15.0 5.0 3.9 22.7 7.8 25.5 17.1 15.3 8.0 14.7 14.3 18.2 15.2 15.0 23.2 16.3 16.0 11.1 18.4 13.8 15.2 0.0 7.0 7.1 35.2 14.9 30.9 27.1 15.6 17.0 10.9 10.7 44.0 45.6 33.0 24.6 20.2 0.0 20.8 4.5 16.4 4.6 0.0 2.7 6.6 16.2 28.6 22.7 0.7 17.8 19.7 0.0 6.6 0.0 0.0 0.1 53.5 0.1 22.0 14.0 60.0 26.1 34.0 1.6 29.9 27.8 29.3 0.1 12.7 20.7 16.0 7.2 18.0 18.3 7.7 0.0 5.5 29.8 25.3 0.0 14.6 7.1 0.1 0.0 0.0 0.0 17.1 0.0 10.8 0.0 9.6 37.2 17.1 43.9 39.2 43.6 49.7 40.4 42.0 39.0 48.2 39.6 42.8 4.6 49.5 37.2 43.7 54.0 42.1 14.7 15.1 14.8 18.6 14.1 14.5 15.9 15.4 16.0 14.7 15.0 15.2 106.0 12.8 19.0 32.0 59.2 51.2 80.6 91.5 49.5 17.4 69.0 112.9 49.3 94.4 48.7 103.0 8.4 51.3 51.1 55.6 127.2 50.0 107.6 138.0 29.6 70.4 54.5 48.2 28.5 58.7 67.0 59.2 31.1 34.1 64.7 93.9 108.1 465.7 89.7 15.2 16.9 73.1 50.8 75.0 48.7 140.6 67.4 44.6 65.8 62.8 56.4 37.2 78.2 23.1 30.7 82.4 57.9 55.3 37.0 47.1 108.4 340.3 102.5 45.6 46.0 48.6 70.6 45.3 81.4 46.9 42.6 26.8 52.5 87.4 63.8 75.2 MGRN1 "KIAA0544, RNF156" ENSG00000102858 "Mahogunin ring finger 1" O60291 16 4616493-4690974 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 16.2" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007653, HPA008033" Approved Supported "Endoplasmic reticulum,Vesicles" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 18: Non-specific - Mitochondria" "Cluster 18: U-2197 - ECM organization" "Cluster 52: Non-specific - Transcription" Vesicles "Endoplasmic reticulum" "HPA007653: AB_1846304, HPA008033: " "unprognostic (2.27e-1)" "unprognostic (1.09e-1)" "unprognostic (1.18e-1)" "unprognostic (1.04e-2)" "unprognostic (1.06e-1)" "unprognostic (1.97e-2)" "unprognostic (4.24e-1)" "unprognostic (1.26e-2)" "unprognostic (9.96e-2)" "unprognostic (1.70e-1)" "unprognostic (4.03e-2)" "unprognostic (9.47e-2)" "unprognostic (6.41e-2)" "unprognostic (2.32e-1)" "unprognostic (9.06e-2)" "unprognostic (1.79e-1)" "unprognostic (5.04e-2)" 23.3 34.3 18.6 25.0 20.6 32.6 22.8 11.9 25.4 28.3 4.9 30.6 28.9 36.9 6.8 20.4 32.1 19.7 26.9 26.4 11.4 24.0 53.5 30.3 18.1 14.1 10.4 30.5 34.6 18.5 33.2 18.5 8.8 30.1 10.9 9.0 25.6 20.5 52.1 23.0 29.9 17.5 8.1 37.7 35.3 18.0 12.0 11.7 28.8 16.7 10.9 28.2 20.6 24.3 13.6 63.9 32.4 33.2 19.0 18.4 44.0 28.7 20.0 23.6 20.0 42.5 31.4 40.0 36.2 35.0 17.6 21.4 26.0 23.6 7.0 56.0 28.8 22.0 45.2 59.6 34.7 32.1 52.3 34.2 15.0 33.0 14.1 17.0 23.0 26.0 32.7 28.6 16.4 59.7 33.3 42.9 48.0 19.2 27.4 60.7 17.0 54.3 20.8 39.3 51.8 42.8 47.6 50.6 28.2 14.8 30.7 31.4 40.8 43.7 24.1 124.3 25.0 44.6 37.8 27.2 18.6 31.8 32.0 5.4 3.5 3.8 2.5 3.9 2.3 1.3 1.4 2.3 2.4 1.5 3.2 1.9 16.2 1.4 2.6 4.1 1.7 3.7 18.6 20.6 11.9 25.4 26.4 11.4 14.1 10.4 8.8 8.1 12.0 24.3 14.7 25.6 34.0 24.2 22.2 9.2 29.5 10.0 6.2 27.3 15.8 11.0 11.4 22.8 9.6 18.4 43.8 23.5 28.2 27.7 5.9 18.6 16.2 20.1 24.2 16.9 37.0 13.7 26.6 22.7 17.7 19.0 44.9 24.5 14.0 30.4 15.0 34.8 30.4 25.2 25.0 23.5 4.1 30.1 21.4 27.2 26.8 27.0 21.4 8.4 36.5 20.8 23.7 18.6 29.8 32.0 15.8 24.8 29.0 23.7 31.7 13.9 11.1 35.2 0.0 20.4 17.6 9.3 12.5 11.9 16.3 34.2 24.0 29.8 23.1 27.8 MIB1 "DIP-1, KIAA1323, MIB, ZZANK2, ZZZ6" ENSG00000101752 "Mindbomb E3 ubiquitin protein ligase 1" Q86YT6 18 21704957-21870953 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Notch signaling pathway, Ubl conjugation pathway" Transferase "Cardiomyopathy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Oligodendrocyte precursor cells: 121.2;Oligodendrocytes: 109.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "REH: 121.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019100, CAB037044" Approved Supported "Vesicles,Plasma membrane" NA NA "Cluster 10: Basophils - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 14: REH - Unknown function" "Cluster 44: Endometrium - Transcription" "Plasma membrane" Vesicles "CAB037044: AB_1841007, HPA019100: AB_1853934" "unprognostic (1.38e-1)" "unprognostic (6.92e-2)" "unprognostic (7.29e-2)" "unprognostic (6.99e-2)" "unprognostic (5.66e-2)" "unprognostic (3.23e-2)" "unprognostic (8.45e-3)" "unprognostic (2.70e-1)" "unprognostic (5.42e-2)" "unprognostic (4.69e-2)" "unprognostic (3.78e-2)" "unprognostic (4.70e-2)" "unprognostic (8.33e-3)" "unprognostic (4.91e-3)" "unprognostic (1.73e-1)" "unprognostic (4.86e-2)" "unprognostic (1.85e-2)" 8.1 6.3 9.1 6.0 9.1 4.9 11.2 9.2 8.5 11.0 8.0 7.1 5.1 13.0 9.5 8.0 7.1 8.6 6.0 8.4 9.2 11.1 10.4 7.2 7.6 9.5 10.2 11.7 8.1 9.8 5.2 11.0 8.6 10.1 7.0 8.3 8.4 8.5 5.8 9.1 5.2 10.2 10.1 7.2 7.6 8.7 10.3 11.5 13.6 7.0 7.9 8.4 8.2 9.6 19.9 7.6 36.4 25.8 19.5 23.0 9.0 15.6 17.2 10.8 15.6 11.3 7.1 16.9 14.1 21.4 11.8 13.2 21.4 21.0 24.4 22.4 10.4 18.8 9.7 15.9 15.8 38.3 7.8 14.8 23.0 12.6 32.0 16.0 27.8 6.6 26.5 47.5 17.2 9.5 18.9 14.7 9.5 12.2 10.2 121.1 30.3 42.5 18.7 16.9 12.1 30.1 26.8 12.4 13.9 18.6 8.8 25.1 23.9 27.8 14.2 11.7 21.1 25.6 9.5 25.4 11.8 24.1 16.9 0.7 0.3 0.1 0.2 0.1 0.2 0.2 0.3 0.2 0.1 0.1 0.2 0.1 0.3 0.5 0.1 0.2 0.4 0.1 9.1 9.1 9.2 8.5 8.4 9.2 9.5 10.2 8.6 10.1 10.3 9.6 35.7 48.1 22.7 68.2 11.9 21.9 15.1 19.8 24.5 28.8 24.1 19.7 18.1 25.8 31.8 16.5 25.0 13.3 18.2 20.8 3.9 13.4 7.0 29.0 59.2 30.8 24.0 23.1 106.7 12.9 7.5 33.1 10.2 32.4 14.5 16.8 24.3 30.0 12.9 15.2 92.6 17.1 26.4 17.2 16.2 5.6 20.5 14.2 26.6 67.5 19.4 17.7 15.5 121.2 109.6 18.8 7.0 24.8 18.1 48.5 8.7 15.9 30.6 14.5 0.0 35.4 26.9 26.2 12.0 23.4 24.6 25.3 14.5 21.8 10.4 25.3 MIB2 "FLJ39787, skeletrophin, ZZANK1, ZZZ5" ENSG00000197530 "Mindbomb E3 ubiquitin protein ligase 2" Q96AX9 1 1615415-1630610 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Notch signaling pathway, Ubl conjugation pathway" "Actin-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 44.0" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 130.9;Late spermatids: 242.0;Suprabasal keratinocytes: 126.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HaCaT: 15.2;SCLC-21H: 15.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA068322 Enhanced NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 59: Non-specific - Translation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 63: NK-cells & T-cells - Immune response" "HPA068322: AB_2685973" "unprognostic (3.93e-2)" "unprognostic (6.02e-2)" "unprognostic (2.34e-2)" "unprognostic (6.60e-2)" "unprognostic (2.08e-1)" "unprognostic (1.70e-2)" "unprognostic (7.36e-3)" "unprognostic (2.61e-1)" "unprognostic (1.54e-1)" "unprognostic (6.57e-2)" "unprognostic (1.15e-3)" "unprognostic (3.17e-2)" "unprognostic (2.22e-3)" "unprognostic (1.29e-1)" "unprognostic (3.58e-2)" "unprognostic (2.49e-1)" "unprognostic (1.01e-2)" 4.5 7.3 2.8 1.1 2.4 0.9 3.9 0.4 7.7 7.6 2.8 7.5 1.2 6.8 0.1 19.9 7.0 0.4 16.4 3.4 2.8 8.5 9.6 4.1 0.4 6.0 0.3 8.3 8.7 0.8 15.6 0.5 0.7 6.8 0.4 0.4 5.7 1.5 44.0 18.9 5.7 0.4 0.0 6.5 6.6 9.6 0.6 0.5 6.2 2.2 0.0 7.3 7.1 1.5 7.6 1.1 0.5 1.7 1.9 0.7 10.2 3.5 1.6 1.1 2.5 1.5 1.9 0.8 4.9 1.0 0.5 15.2 0.5 2.3 0.0 4.0 6.3 0.6 2.5 1.5 2.6 1.0 2.5 1.5 1.6 0.7 0.2 0.7 0.6 3.4 3.1 1.3 0.3 1.2 4.2 9.7 1.3 1.9 11.8 7.1 2.1 10.8 0.1 0.9 15.7 5.7 5.9 0.8 6.5 0.3 1.1 3.7 0.7 1.0 2.4 5.7 1.0 7.6 2.4 2.2 2.6 3.1 1.3 0.0 0.1 1.7 3.2 0.1 3.2 2.6 2.4 3.5 0.0 3.3 2.9 2.2 0.3 6.3 0.0 7.3 2.0 0.8 2.8 2.4 0.4 7.7 3.4 2.8 6.0 0.3 0.7 0.0 0.6 1.5 15.2 0.0 8.4 21.5 20.0 130.9 16.2 17.1 86.0 35.1 18.5 18.4 11.2 18.6 11.3 23.9 12.5 11.1 61.2 50.8 9.8 7.9 75.9 19.0 12.2 12.1 15.0 5.7 18.5 1.3 10.3 16.0 34.7 13.1 20.3 32.5 17.5 10.6 6.6 26.9 13.5 35.7 8.2 11.6 22.2 242.0 21.1 12.4 17.8 4.7 8.9 30.0 110.2 10.1 11.9 5.8 50.3 15.8 19.5 12.1 44.6 20.8 10.2 35.7 0.0 17.0 20.1 22.3 45.6 85.6 126.0 15.1 43.3 20.6 38.2 18.3 MID1 "FXY, OS, RNF59, TRIM18" ENSG00000101871 "Midline 1" O15344 X 10445310-10833654 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 129.3;Basal squamous epithelial cells: 82.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 156.1;AF22: 132.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA002878, HPA003715" Approved Uncertain "Golgi apparatus,Centriolar satellite,Cytosol" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 64: Astrocytes - Nervous system maintenance" "Centriolar satellite" "Golgi apparatus, Cytosol" "HPA002878: , HPA003715: AB_1079384" "unprognostic (1.99e-1)" "unprognostic (2.81e-1)" "unprognostic (4.66e-2)" "unprognostic (2.79e-1)" "unprognostic (2.78e-1)" "unprognostic (2.61e-1)" "prognostic unfavorable (3.06e-4)" "unprognostic (1.19e-1)" "unprognostic (3.61e-1)" "unprognostic (2.09e-1)" "unprognostic (2.87e-1)" "unprognostic (9.43e-2)" "unprognostic (1.25e-3)" "unprognostic (9.89e-2)" "unprognostic (1.49e-1)" "unprognostic (1.12e-3)" "unprognostic (5.88e-2)" 5.9 2.5 6.9 5.0 7.7 1.7 5.3 17.2 5.0 7.0 6.5 17.3 5.7 8.9 4.9 7.0 6.4 6.8 9.3 7.0 4.9 7.3 4.2 6.5 2.2 3.6 10.4 4.4 3.5 2.8 4.2 6.2 4.9 10.4 10.6 12.3 4.9 12.9 0.7 2.9 5.8 12.3 2.1 1.0 3.8 3.6 8.2 2.3 4.2 2.2 3.1 11.7 6.2 4.4 33.2 156.1 132.5 16.7 8.1 9.2 14.6 16.2 17.8 19.7 20.7 31.0 9.7 10.6 6.5 21.9 58.4 22.5 11.0 15.1 23.0 1.3 11.0 2.7 24.3 1.1 2.8 0.3 1.2 12.1 7.0 16.1 15.8 20.4 23.1 5.1 2.1 3.2 9.6 8.0 5.3 0.5 32.7 5.1 10.0 3.9 28.9 0.4 18.7 36.2 7.1 3.5 7.4 23.5 10.1 42.7 19.2 0.2 13.7 7.2 1.0 34.1 17.0 2.8 1.2 0.4 13.5 0.3 31.3 0.5 0.1 0.6 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.3 0.0 0.1 0.7 0.0 0.1 0.4 0.0 0.1 6.9 7.7 17.2 5.0 7.0 4.9 3.6 10.4 4.9 2.1 8.2 4.4 16.5 35.3 20.7 129.3 0.7 21.4 31.5 24.7 82.6 10.7 8.5 13.2 4.8 8.6 19.6 23.9 18.8 9.1 1.3 22.6 1.9 13.4 2.2 39.8 8.9 25.4 12.1 2.7 15.5 8.7 26.9 16.2 10.7 38.5 1.3 13.4 69.9 4.0 1.5 69.0 44.3 9.0 2.0 2.5 5.8 7.9 30.1 1.2 3.6 23.4 0.0 37.0 0.0 66.4 59.2 7.3 17.2 41.3 0.2 8.2 11.3 1.5 19.3 2.9 6.6 3.7 3.3 0.3 2.4 36.1 10.1 20.0 0.8 9.7 20.0 49.2 MINK1 "B55, MAP4K6, MINK, YSK2, ZC3" ENSG00000141503 "Misshapen like kinase 1" Q8N4C8 17 4833340-4898061 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056296 Approved NA NA 26000 "Cluster 52: Eosinophils - Transcription" "Cluster 31: Skin - Epidermis development" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 61: Squamous epithelial cells - Keratinization" "HPA056296: AB_2683090" "unprognostic (2.80e-1)" "unprognostic (3.83e-2)" "unprognostic (1.85e-1)" "unprognostic (6.62e-2)" "unprognostic (2.88e-1)" "unprognostic (3.26e-3)" "prognostic unfavorable (3.00e-4)" "unprognostic (4.64e-3)" "unprognostic (3.21e-1)" "unprognostic (2.78e-2)" "prognostic favorable (2.77e-4)" "prognostic unfavorable (9.27e-4)" "unprognostic (8.44e-3)" "unprognostic (2.49e-2)" "unprognostic (1.37e-1)" "unprognostic (2.47e-2)" "unprognostic (1.62e-1)" 22.8 21.5 32.4 24.9 29.8 22.7 24.7 13.0 34.4 32.0 0.0 36.9 43.0 19.1 5.7 72.1 21.3 18.6 15.4 50.7 15.1 23.0 17.5 35.6 23.9 17.7 16.2 36.9 29.4 23.2 25.7 23.2 15.3 25.5 28.1 18.2 32.4 12.2 12.5 76.9 41.7 14.6 13.4 27.6 29.0 14.2 26.4 16.8 21.9 9.9 18.8 21.8 46.6 20.2 46.9 83.6 20.2 31.2 29.7 21.8 56.0 37.4 34.2 27.6 24.7 32.3 31.3 34.5 41.5 38.2 30.0 91.8 15.5 64.2 20.2 49.0 41.2 23.9 62.8 25.3 18.8 9.1 45.2 22.4 44.1 27.1 25.2 24.9 30.8 10.8 25.6 27.4 22.9 27.8 14.8 20.2 15.6 30.4 28.4 17.9 16.9 20.4 42.2 53.9 20.9 16.6 40.1 30.7 23.9 24.2 27.7 12.2 45.0 29.6 13.7 52.8 35.6 16.8 14.6 7.3 26.7 19.2 20.5 0.0 0.7 2.9 1.0 0.6 1.2 1.1 1.1 0.8 0.5 0.7 0.7 0.3 0.6 0.1 0.3 0.3 1.3 1.2 32.4 29.8 13.0 34.4 50.7 15.1 17.7 16.2 15.3 13.4 26.4 20.2 18.1 0.0 2.0 51.9 12.7 41.0 14.7 22.0 37.5 7.2 17.3 18.8 1.4 22.8 9.9 5.5 39.6 18.9 10.2 47.3 5.9 9.5 3.6 10.6 8.6 15.4 18.7 13.0 25.5 10.5 13.3 8.5 51.0 12.7 8.2 21.1 16.1 9.8 18.3 13.5 24.7 30.3 16.2 12.3 16.7 6.8 16.1 13.9 16.0 37.5 29.5 6.9 9.2 13.0 48.1 14.8 46.7 14.7 9.7 19.9 29.3 13.0 12.8 16.9 13.1 6.9 7.6 5.8 13.8 40.9 60.5 19.6 15.9 28.3 27.4 20.1 MKNK1 MNK1 ENSG00000079277 "MAPK interacting serine/threonine kinase 1" Q9BUB5 1 46557407-46616843 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Translation regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "pancreas: 128.6" "Cell type enhanced" "Detected in all" "Hofbauer cells: 142.8;Microglial cells: 100.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB027355, CAB037310, HPA071293" Approved Supported Nucleoplasm NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 36: HEL - Hemostasis" "Cluster 4: Macrophages - Innate immune response" Nucleoplasm "CAB027355: AB_2266303, CAB037310: AB_1854049, HPA071293: AB_2686382" "unprognostic (4.05e-3)" "prognostic favorable (7.05e-4)" "unprognostic (5.28e-2)" "unprognostic (3.47e-2)" "unprognostic (1.64e-1)" "unprognostic (7.38e-2)" "prognostic unfavorable (1.24e-5)" "unprognostic (3.50e-2)" "unprognostic (1.77e-1)" "unprognostic (2.60e-1)" "unprognostic (1.50e-1)" "unprognostic (2.14e-2)" "prognostic unfavorable (1.51e-5)" "unprognostic (7.02e-2)" "unprognostic (3.19e-2)" "unprognostic (4.67e-1)" "unprognostic (5.67e-3)" 30.6 21.8 15.5 23.5 14.4 30.3 23.1 19.0 18.0 22.8 17.0 27.4 15.6 18.5 12.0 23.5 21.4 16.1 22.3 15.1 14.6 17.5 21.8 31.5 17.0 14.2 13.3 19.0 128.6 12.0 18.4 22.1 14.4 19.4 17.7 3.9 16.7 8.5 23.9 18.0 24.9 18.4 13.7 48.1 23.1 12.4 16.6 22.6 16.2 23.9 13.8 20.1 20.7 16.5 34.1 21.7 13.5 15.7 12.0 17.9 18.0 16.7 16.4 20.7 27.1 26.4 13.5 23.1 20.2 17.8 23.0 38.5 23.8 27.5 23.1 37.7 21.4 47.8 28.3 21.7 17.3 25.4 34.8 22.0 17.7 25.2 13.4 10.8 24.1 26.2 24.7 16.6 12.2 21.5 18.3 21.8 9.9 19.6 24.8 16.7 30.5 22.1 20.2 35.2 10.4 9.0 32.3 27.9 25.6 26.5 21.5 28.6 18.5 7.6 1.4 22.2 19.9 12.6 23.7 21.2 14.6 31.9 13.4 9.7 26.3 36.1 15.3 25.7 44.7 9.9 12.9 14.2 13.1 11.6 9.2 13.9 69.7 11.2 20.6 9.7 10.6 14.5 15.5 14.4 19.0 18.0 15.1 14.6 14.2 13.3 14.4 13.7 16.6 16.5 20.3 12.8 21.5 41.4 15.3 13.9 17.8 15.2 9.1 19.4 17.8 12.3 19.2 15.7 17.8 22.0 2.1 21.6 23.7 27.9 7.9 18.9 15.5 12.5 12.8 18.3 16.8 21.9 42.2 37.1 34.2 20.5 11.7 13.3 12.0 22.8 18.2 22.7 142.8 18.5 52.7 12.0 4.1 84.5 61.0 23.8 21.5 49.9 10.6 100.2 26.7 5.2 21.6 21.6 8.5 32.3 17.7 36.5 13.3 19.5 27.8 15.7 11.1 5.0 6.6 31.2 15.0 15.3 17.2 22.6 11.1 18.5 25.2 35.1 15.0 29.6 MKNK2 "GPRK7, MNK2" ENSG00000099875 "MAPK interacting serine/threonine kinase 2" Q9HBH9 19 2037465-2051244 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Translation regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 475.7;tongue: 551.1" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HHSteC: 367.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021875, CAB037253, HPA070499" Supported Supported "Nuclear bodies" No No "Cluster 33: Neutrophils - Chromatin organization" "Cluster 80: Striated muscle - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 7: Non-specific - Mitochondria" "Nuclear bodies" "CAB037253: AB_1079401, HPA021875: AB_1854050, HPA070499: AB_2732157" "unprognostic (8.76e-2)" "unprognostic (1.71e-1)" "unprognostic (1.64e-1)" "prognostic favorable (4.86e-5)" "unprognostic (3.08e-1)" "unprognostic (1.59e-2)" "unprognostic (6.42e-3)" "unprognostic (1.35e-1)" "unprognostic (4.32e-2)" "unprognostic (7.52e-2)" "unprognostic (1.08e-1)" "unprognostic (6.56e-2)" "unprognostic (4.07e-2)" "prognostic favorable (4.01e-4)" "unprognostic (1.63e-1)" "unprognostic (1.60e-1)" "unprognostic (1.59e-1)" 87.2 50.2 70.5 51.3 78.0 133.6 39.5 109.2 131.2 41.9 80.6 55.2 47.4 24.7 47.8 114.5 38.1 26.7 54.8 67.2 65.4 27.6 71.2 51.8 66.8 80.3 70.7 34.5 191.9 34.5 39.6 35.3 74.6 38.6 30.0 35.7 133.8 39.7 475.7 63.8 57.3 21.8 68.2 80.2 55.1 21.6 75.7 34.5 54.6 551.1 58.6 39.9 60.9 91.0 64.9 71.8 30.1 66.3 219.5 79.0 65.1 37.3 27.1 26.5 26.8 45.5 111.8 88.2 50.7 77.4 27.9 78.4 38.4 110.9 12.0 122.1 34.4 36.8 62.1 49.2 367.4 72.3 61.6 84.1 262.0 50.8 107.2 61.9 63.5 59.2 62.0 155.4 18.6 37.7 42.8 59.3 78.6 49.6 78.1 81.8 8.6 113.1 48.1 41.2 39.9 48.2 89.0 125.1 166.4 33.5 52.7 89.5 96.5 9.5 37.5 38.5 46.0 238.9 97.0 85.7 78.2 53.5 17.9 4.4 9.2 9.8 8.1 10.2 7.5 16.9 8.4 9.4 7.7 15.0 5.4 6.6 41.7 9.5 13.6 9.2 12.5 3.6 70.5 78.0 109.2 131.2 67.2 65.4 80.3 70.7 74.6 68.2 75.7 91.0 102.2 38.5 56.5 9.8 91.4 82.5 105.6 84.5 50.1 55.7 99.0 103.5 54.5 38.6 65.5 36.8 25.0 23.5 106.5 155.3 9.8 27.3 8.7 60.2 28.0 51.9 150.2 80.2 5.6 56.6 47.2 45.0 57.6 76.2 29.2 14.5 82.5 60.3 36.9 42.1 5.9 104.1 46.8 52.5 134.6 13.0 20.2 68.0 56.9 8.4 41.8 63.6 30.9 6.0 5.2 47.2 86.6 20.3 55.4 94.2 98.8 18.6 55.2 47.5 19.7 132.6 48.7 18.1 19.5 97.8 117.2 56.5 69.3 18.1 79.7 114.0 MKRN1 RNF61 ENSG00000133606 "Makorin ring finger protein 1" Q9UHC7 7 140453033-140479536 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 328.0;Erythroid cells: 424.2;Late spermatids: 340.6" "Cancer enriched" "Detected in all" 5 "testis cancer: 129.7" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000567 Approved Nucleoplasm,Cytosol NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 29: U-266 - Adaptive immune response" "Cluster 6: Erythroid cells - Oxygen transport" "Nucleoplasm, Cytosol" "HPA000567: AB_1079299" "unprognostic (9.97e-2)" "unprognostic (1.50e-1)" "unprognostic (1.27e-1)" "unprognostic (7.60e-3)" "unprognostic (1.65e-2)" "unprognostic (2.41e-1)" "unprognostic (4.87e-3)" "unprognostic (1.24e-2)" "unprognostic (8.02e-2)" "unprognostic (2.97e-2)" "unprognostic (2.52e-1)" "unprognostic (1.35e-1)" "unprognostic (2.89e-3)" "unprognostic (5.76e-2)" "unprognostic (2.42e-1)" "unprognostic (1.22e-1)" "unprognostic (1.22e-2)" 39.5 36.8 50.9 47.9 50.7 202.6 47.8 52.6 57.1 43.0 46.6 97.9 69.2 46.7 43.3 49.0 51.3 37.5 64.6 51.0 53.7 47.9 42.7 46.9 49.7 57.6 50.7 56.5 58.1 66.8 42.3 43.0 58.9 48.6 80.1 58.6 56.5 44.4 84.0 51.7 65.8 43.5 50.2 52.7 53.9 123.2 55.6 47.1 46.9 58.5 56.4 45.7 38.9 50.9 96.5 72.3 55.6 83.1 86.5 75.5 78.2 64.6 83.3 49.8 57.2 30.0 98.8 69.4 98.4 63.4 99.2 45.7 63.2 71.2 62.8 138.0 55.6 72.1 43.5 55.9 69.4 62.5 107.1 75.4 105.1 56.2 52.8 81.9 50.8 46.9 58.0 84.8 49.1 82.6 73.4 114.2 143.3 80.7 53.6 52.4 47.4 107.6 80.8 109.2 76.6 79.1 80.8 108.5 120.6 81.6 53.3 53.5 71.9 34.9 27.4 85.8 59.8 200.2 159.2 60.9 99.3 96.1 73.3 58.6 22.5 100.4 15.4 21.3 18.0 33.6 29.5 23.0 18.0 32.9 39.9 25.5 42.5 31.1 26.5 6.0 35.3 15.3 50.9 50.7 52.6 57.1 51.0 53.7 57.6 50.7 58.9 50.2 55.6 50.9 28.4 51.3 37.2 13.4 76.8 82.1 66.6 57.1 57.5 61.5 60.9 36.2 57.7 67.2 71.1 42.3 35.5 75.8 54.0 172.1 103.7 69.8 328.0 58.4 30.6 34.2 97.3 424.2 28.9 67.8 96.6 43.3 38.7 65.7 37.4 79.5 45.7 45.0 59.5 119.5 28.0 107.7 89.5 95.9 93.3 340.6 66.5 86.3 69.4 22.5 119.0 61.4 92.7 15.1 22.1 57.6 140.3 62.4 41.8 101.2 112.4 54.4 70.0 46.4 46.0 34.7 53.3 303.0 60.1 62.4 95.5 138.0 62.9 39.6 103.5 145.9 MKRN2 "HSPC070, RNF62" ENSG00000075975 "Makorin ring finger protein 2" Q9H000 3 12557057-12586208 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 10 "Early spermatids: 572.9;Late spermatids: 774.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037559, HPA037560" Enhanced Approved Nucleoplasm,Cytosol NA NA "Cluster 44: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 28: BEWO - Transcription regulation" "Cluster 34: Spermatids - Unknown function" "Nucleoplasm, Cytosol" "HPA037559: AB_10672460, HPA037560: AB_10696936" "unprognostic (4.17e-2)" "unprognostic (1.08e-1)" "unprognostic (1.59e-2)" "unprognostic (5.99e-2)" "unprognostic (3.89e-2)" "unprognostic (1.47e-2)" "prognostic unfavorable (1.58e-4)" "unprognostic (4.38e-1)" "unprognostic (8.49e-2)" "unprognostic (2.86e-1)" "unprognostic (1.42e-1)" "unprognostic (2.56e-3)" "prognostic favorable (6.04e-4)" "unprognostic (3.26e-1)" "unprognostic (2.22e-1)" "unprognostic (1.33e-2)" "unprognostic (3.32e-2)" 16.3 11.5 15.1 10.9 15.1 3.5 13.8 16.9 17.6 15.7 13.5 16.3 13.0 16.6 12.0 17.9 14.7 11.6 32.5 15.1 17.0 16.0 15.1 13.4 14.5 15.5 15.9 21.7 24.1 23.9 12.8 16.7 16.1 12.5 13.5 11.4 14.0 14.0 32.0 14.5 12.2 18.9 16.7 10.7 13.7 56.3 16.7 21.4 21.1 24.5 17.3 15.3 14.3 17.6 20.6 18.8 24.5 17.4 45.2 44.3 40.6 30.0 35.5 41.7 34.1 19.2 18.8 26.7 16.9 37.7 18.8 10.9 38.4 33.1 37.1 30.9 29.2 40.3 19.1 31.1 51.9 38.8 14.4 46.8 30.6 47.6 30.2 34.8 34.9 39.1 39.7 30.8 37.7 25.9 51.4 17.8 16.5 21.7 40.4 45.9 26.0 32.2 30.4 24.8 14.8 26.4 28.4 12.8 30.4 17.3 29.7 38.0 31.1 23.0 23.0 28.5 43.0 26.6 62.8 60.8 28.8 49.5 41.1 20.9 17.9 32.9 20.7 16.4 26.4 21.3 21.4 22.0 19.8 16.5 22.8 20.8 13.2 27.8 23.3 15.9 24.5 20.2 15.1 15.1 16.9 17.6 15.1 17.0 15.5 15.9 16.1 16.7 16.7 17.6 15.4 19.2 9.6 9.8 13.8 9.6 9.9 13.5 10.2 13.8 8.5 8.9 14.7 1.5 14.2 5.5 4.2 19.7 20.8 7.6 19.6 16.1 572.9 9.7 13.8 14.1 2.4 5.0 15.9 16.8 19.6 11.4 5.1 10.1 19.0 17.3 7.9 5.8 15.5 11.8 15.5 10.0 6.1 7.2 9.1 774.2 20.5 9.6 16.0 6.5 20.1 19.1 20.6 14.1 11.1 16.0 10.8 20.7 14.7 9.5 12.0 11.6 14.2 13.2 13.1 11.3 17.4 66.5 38.4 8.1 9.2 16.1 15.7 23.6 10.1 9.8 MKRN3 "D15S9, MGC88288, RNF63, ZFP127, ZNF127" ENSG00000179455 "Makorin ring finger protein 3" Q13064 15 23565674-23630075 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 14.1;retina: 8.9" "Cell type enhanced" "Detected in some" "Bipolar cells: 13.8;Cone photoreceptor cells: 25.0;Horizontal cells: 6.7;Oligodendrocyte precursor cells: 6.0;Oligodendrocytes: 9.0;Rod photoreceptor cells: 7.4" "Cancer enhanced" "Detected in some" "glioma: 1.5" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "naive CD8 T-cell: 2.3" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "JURKAT: 26.3;K-562: 30.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA029494 Uncertain Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 1: K-562 - Erythropoiesis" "Cluster 9: Photoreceptor cells - Phototransduction" "Plasma membrane, Cytosol" Nucleoplasm "HPA029494: AB_10603873" "unprognostic (3.18e-1)" "unprognostic (1.26e-1)" "unprognostic (4.26e-1)" "unprognostic (1.86e-3)" "unprognostic (1.04e-3)" "unprognostic (1.15e-2)" "unprognostic (6.27e-4)" "unprognostic (1.51e-1)" "unprognostic (8.52e-2)" "unprognostic (7.05e-2)" "unprognostic (4.97e-3)" "unprognostic (2.86e-1)" "unprognostic (1.05e-4)" "unprognostic (5.37e-2)" "unprognostic (1.52e-1)" "unprognostic (8.91e-2)" "unprognostic (9.78e-2)" 0.3 0.1 4.5 0.4 7.7 1.8 0.5 4.8 6.7 0.1 2.4 0.5 0.2 0.4 1.6 3.4 3.1 0.1 0.1 5.2 5.1 0.3 0.1 0.2 0.7 7.0 6.1 0.2 0.4 0.0 1.1 3.3 7.0 0.3 0.1 8.9 3.1 0.2 0.8 0.4 0.3 0.1 4.0 0.6 0.2 2.4 6.6 2.4 0.2 0.8 0.8 0.2 0.2 14.1 8.5 2.9 6.1 5.6 0.0 0.0 13.0 0.9 0.0 4.3 4.5 14.7 0.0 0.1 0.1 0.0 11.8 12.5 2.4 0.0 2.7 0.1 0.5 15.3 17.0 0.9 0.4 18.6 10.2 0.6 0.0 5.8 0.0 2.8 0.0 26.3 30.6 12.9 3.5 0.0 20.3 7.3 0.0 9.6 12.1 10.7 2.5 7.5 0.0 0.1 1.6 4.4 0.0 7.7 0.1 0.2 4.2 5.2 0.1 13.5 9.9 0.9 9.6 16.8 24.5 8.6 7.9 0.1 0.1 0.6 0.2 0.1 0.6 0.0 0.3 0.2 0.2 0.4 0.0 0.2 0.6 2.3 0.4 0.1 0.1 0.3 0.1 0.3 4.5 7.7 4.8 6.7 5.2 5.1 7.0 6.1 7.0 4.0 6.6 14.1 0.0 0.0 0.0 0.7 0.1 0.5 1.2 0.0 0.0 13.8 0.3 0.0 0.7 0.0 0.1 0.0 25.0 0.8 0.0 0.0 0.0 0.0 0.8 0.1 0.2 0.2 0.0 0.0 0.0 0.0 0.3 0.4 0.0 0.0 0.0 0.4 0.0 0.0 0.0 6.7 0.4 0.0 0.0 0.0 0.6 0.5 0.0 0.1 1.8 1.0 0.1 3.4 0.0 6.0 9.0 0.0 0.0 0.4 0.0 0.5 0.0 0.0 0.2 7.4 0.0 0.7 1.6 2.6 0.9 1.8 0.0 0.5 0.2 0.1 0.0 0.4 MLKL FLJ34389 ENSG00000168404 "Mixed lineage kinase domain like pseudokinase" Q8NB16 16 74671855-74700960 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transporters" Necrosis "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Adipocytes: 32.1;Endothelial cells: 25.9;granulocytes: 29.1;Macrophages: 28.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA078638 Supported "Plasma membrane,Cell Junctions,Cytosol" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 11: Alveolar cells - Smell perception" "Plasma membrane" "Cell Junctions, Cytosol" "HPA078638: " "unprognostic (7.53e-2)" "unprognostic (1.74e-2)" "unprognostic (2.57e-1)" "prognostic favorable (2.16e-4)" "unprognostic (1.23e-1)" "unprognostic (3.07e-1)" "unprognostic (5.69e-2)" "unprognostic (3.67e-3)" "unprognostic (1.90e-1)" "unprognostic (6.64e-3)" "unprognostic (1.37e-1)" "unprognostic (2.74e-1)" "unprognostic (1.60e-3)" "unprognostic (5.30e-2)" "unprognostic (1.26e-2)" "unprognostic (1.06e-1)" "unprognostic (1.53e-3)" 20.0 7.1 8.4 20.3 8.7 30.7 12.1 8.6 12.7 9.0 9.6 11.0 11.0 6.0 2.0 15.6 8.0 11.5 10.6 7.8 8.2 15.4 9.3 25.6 15.4 10.1 9.8 3.0 9.9 1.6 3.7 9.2 9.3 8.4 11.4 0.3 13.3 4.3 3.1 4.9 14.4 7.6 9.1 36.1 10.8 1.2 10.3 6.7 8.7 3.1 13.8 12.3 11.5 9.6 13.5 24.4 0.1 0.1 6.0 12.4 0.2 17.0 14.8 15.4 22.4 13.9 26.6 0.3 19.1 14.2 13.7 21.7 4.3 24.9 5.8 8.3 0.6 18.8 17.6 16.2 4.2 12.3 18.6 8.5 2.4 16.8 5.7 9.0 37.3 21.3 2.7 2.5 11.9 22.0 7.0 24.3 2.2 29.3 30.0 13.5 1.8 23.8 22.0 10.2 1.0 0.8 13.4 8.7 7.2 0.1 6.2 12.5 41.4 7.8 4.8 7.0 11.7 11.2 40.2 3.2 13.7 42.3 3.9 21.9 36.2 45.8 11.2 22.2 15.4 8.1 12.6 12.0 18.9 6.7 6.8 10.4 48.6 3.6 23.3 1.2 17.4 16.0 8.4 8.7 8.6 12.7 7.8 8.2 10.1 9.8 9.3 9.1 10.3 9.6 32.1 3.2 10.7 1.0 9.8 3.4 6.8 3.1 7.4 0.2 3.3 3.4 3.1 2.8 5.5 1.8 0.0 0.2 9.6 8.9 1.9 4.6 3.5 1.2 1.9 25.9 1.2 3.4 0.5 5.2 0.8 7.1 15.3 1.6 29.1 0.3 16.8 1.3 16.6 1.7 0.5 10.9 0.0 18.2 7.8 5.2 0.9 28.9 7.2 11.2 16.7 0.1 11.3 1.5 5.2 4.9 9.4 0.4 18.5 2.8 5.5 0.6 2.0 0.6 0.0 3.0 3.1 0.1 0.2 13.4 2.8 0.3 16.5 0.2 9.5 7.5 MOK "RAGE, RAGE1, STK30" ENSG00000080823 "MOK protein kinase" Q9UQ07 14 102224500-102305190 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "retina: 125.8;testis: 54.0" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 185.6;Early spermatids: 212.8;Late spermatids: 185.8;Respiratory ciliated cells: 156.9;Rod photoreceptor cells: 465.7" "Cancer enriched" "Detected in many" 4 "melanoma: 7.4" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "NK-cell: 8.0" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HBF TERT88: 149.0;hTEC/SVTERT24-B: 383.5;NB-4: 499.1;U-138 MG: 200.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027292 Supported "Endoplasmic reticulum" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 77: Retina - Visual perception" "Cluster 24: NB-4 - Immune response" "Cluster 46: Photoreceptor cells - Phototransduction" "Endoplasmic reticulum" "HPA027292: AB_10600989" "unprognostic (8.16e-2)" "unprognostic (1.82e-1)" "unprognostic (6.68e-2)" "unprognostic (6.05e-3)" "unprognostic (1.34e-2)" "unprognostic (1.81e-2)" "unprognostic (4.43e-2)" "unprognostic (3.49e-4)" "unprognostic (2.19e-1)" "unprognostic (2.03e-2)" "unprognostic (2.93e-1)" "unprognostic (3.01e-3)" "unprognostic (5.97e-2)" "unprognostic (1.81e-1)" "unprognostic (2.17e-1)" "unprognostic (1.26e-2)" "unprognostic (2.48e-1)" 9.2 11.2 15.7 1.8 16.0 3.0 6.8 14.8 18.6 8.9 26.9 5.3 3.4 7.8 7.3 4.3 21.2 4.6 13.0 17.2 16.9 12.6 5.8 5.3 1.7 16.2 17.2 12.9 9.7 7.1 18.6 2.4 15.9 7.6 1.8 125.8 6.3 3.5 2.2 6.8 3.0 3.9 15.0 4.7 9.3 54.0 17.1 1.7 14.8 0.7 1.3 8.4 5.5 15.6 18.9 16.5 2.2 9.5 3.8 13.1 4.2 37.7 11.0 53.4 63.7 1.5 45.4 14.5 3.1 7.2 11.5 4.1 3.3 19.4 149.0 16.2 14.1 3.4 2.3 12.7 15.9 1.6 17.9 11.1 4.9 383.5 35.3 41.3 2.0 2.9 3.4 1.0 35.3 12.5 1.2 499.1 0.7 8.3 39.4 2.2 1.0 0.3 21.9 0.8 6.0 3.9 6.8 2.6 109.4 0.8 11.2 1.5 1.4 200.4 10.4 7.7 12.1 1.3 2.4 1.2 40.2 1.2 93.1 0.0 0.7 0.0 0.5 0.6 0.8 0.0 0.4 1.4 3.0 0.5 0.7 1.7 0.5 8.0 0.1 0.0 0.0 0.9 15.7 16.0 14.8 18.6 17.2 16.9 16.2 17.2 15.9 15.0 17.1 15.6 5.8 19.2 17.5 68.6 1.0 10.7 6.3 12.0 7.4 40.9 19.1 17.3 12.3 10.0 27.5 12.9 185.6 1.4 2.4 6.1 5.9 8.3 212.8 122.1 16.9 7.2 4.8 3.6 54.7 16.0 2.6 17.6 12.2 10.7 3.8 12.2 8.6 2.0 2.1 16.8 37.5 2.4 6.1 1.3 5.3 185.8 30.4 2.5 80.0 7.5 0.5 59.5 1.0 16.1 6.8 6.5 1.2 16.1 1.1 2.7 3.5 11.1 156.9 465.7 26.3 22.4 13.4 121.4 32.0 5.4 5.8 1.2 4.2 13.4 4.2 3.8 MOS ENSG00000172680 "MOS proto-oncogene, serine/threonine kinase" P00540 8 56112942-56113982 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" Proto-oncogene "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "Early spermatids: 6.5;Spermatocytes: 3.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" NA NA "Cluster 66: Spermatocytes - Spermatogenesis" "unprognostic (3.28e-1)" 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 MRPL58 "DS-1, ICT1" ENSG00000167862 "Mitochondrial ribosomal protein L58" Q14197 17 75012670-75021261 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Ribosomal proteins" "Protein biosynthesis" "Hydrolase, Ribonucleoprotein, Ribosomal protein" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 60.1;Distal tubular cells: 56.7;Ductal cells: 50.9;Exocrine glandular cells: 60.3;Hofbauer cells: 48.1;Pancreatic endocrine cells: 53.7;Proximal tubular cells: 121.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003634, HPA076987" Approved Supported "Nucleoplasm,Plasma membrane,Mitochondria" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" Mitochondria "Nucleoplasm, Plasma membrane" "HPA003634: AB_1851388, HPA076987: " "unprognostic (2.04e-1)" "unprognostic (1.57e-2)" "unprognostic (1.94e-3)" "unprognostic (7.12e-2)" "unprognostic (3.16e-2)" "unprognostic (4.35e-2)" "unprognostic (1.38e-3)" "unprognostic (1.52e-1)" "unprognostic (2.57e-1)" "unprognostic (3.79e-3)" "unprognostic (4.98e-2)" "unprognostic (2.43e-2)" "prognostic unfavorable (2.09e-4)" "unprognostic (1.10e-1)" "unprognostic (1.12e-1)" "unprognostic (2.66e-2)" "unprognostic (1.71e-1)" 22.7 36.3 22.1 18.0 22.8 22.8 24.6 24.4 23.0 17.1 31.9 25.9 19.1 19.4 18.2 32.1 17.5 13.1 49.1 21.9 23.6 34.7 47.2 16.3 24.4 23.4 22.6 14.2 27.4 25.0 14.0 19.3 23.4 18.6 22.8 11.2 21.8 18.6 79.0 28.4 21.7 18.8 23.3 21.6 26.0 10.5 22.9 18.3 18.7 50.3 23.8 24.5 19.9 24.5 81.1 111.4 36.5 42.1 38.3 37.9 50.5 46.7 50.7 95.7 80.7 86.3 49.5 56.0 37.3 46.8 58.9 56.3 75.6 80.7 100.2 28.1 87.7 43.8 50.5 72.2 72.5 92.5 28.8 40.9 37.8 63.3 101.0 32.3 73.8 57.0 71.7 39.9 54.8 100.9 80.7 63.4 27.5 125.3 147.1 41.2 64.8 81.2 71.1 58.5 33.5 64.1 40.3 72.5 92.9 46.7 97.5 75.6 31.6 50.8 56.0 54.3 89.7 41.0 34.8 63.2 58.5 102.5 43.5 26.6 41.2 21.4 30.8 40.9 27.1 33.8 38.0 31.4 55.3 29.3 27.8 31.1 4.0 42.2 36.1 37.2 67.2 42.5 22.1 22.8 24.4 23.0 21.9 23.6 23.4 22.6 23.4 23.3 22.9 24.5 18.8 32.1 8.7 0.0 4.3 0.0 0.0 0.0 0.0 0.0 22.5 32.8 0.0 0.0 8.1 25.8 0.0 60.1 11.4 0.0 56.7 50.9 0.0 29.3 18.3 8.4 0.0 0.0 0.0 60.3 40.5 8.9 0.0 19.0 1.3 22.3 0.0 0.0 48.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.3 0.0 0.0 15.0 0.0 0.0 0.0 0.0 53.7 0.0 0.0 0.8 0.0 0.0 121.1 21.1 0.0 0.0 0.0 12.8 0.0 0.0 0.0 0.0 29.1 7.4 43.5 0.0 0.0 MSRA ENSG00000175806 "Methionine sulfoxide reductase A" Q9UJ68 8 10054292-10428891 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 86.0;liver: 64.0" "Cell type enhanced" "Detected in many" "Excitatory neurons: 625.8;Inhibitory neurons: 318.6;Oligodendrocyte precursor cells: 268.9;Proximal tubular cells: 666.1" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in many" 5 "cerebellum: 28.4" "Immune cell enhanced" "Detected in some" "eosinophil: 5.6" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HMC-1: 12.3" "Low region specificity" "Detected in all" "HPA023804, HPA075766" Approved Supported "Nucleoplasm,Plasma membrane,Actin filaments,Cytosol" "Intracellular and membrane" No No 55000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 3: HMC-1 - Innate immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nucleoplasm, Cytosol" "Plasma membrane, Actin filaments" "HPA023804: AB_1853826, HPA075766: " "unprognostic (1.55e-1)" "unprognostic (4.30e-3)" "unprognostic (1.45e-3)" "unprognostic (1.00e-2)" "unprognostic (4.21e-2)" "unprognostic (1.62e-2)" "unprognostic (1.49e-2)" "unprognostic (6.40e-2)" "unprognostic (9.69e-2)" "unprognostic (1.08e-1)" "unprognostic (1.80e-1)" "unprognostic (4.58e-2)" "unprognostic (1.07e-3)" "unprognostic (6.43e-3)" "unprognostic (4.02e-1)" "unprognostic (6.36e-3)" "unprognostic (3.07e-1)" 17.0 20.4 2.2 1.1 3.0 13.5 16.1 28.4 5.4 9.1 0.0 13.9 1.1 10.7 0.1 11.6 7.4 0.4 29.0 3.8 0.0 86.0 64.0 12.2 0.6 0.0 0.4 6.4 14.5 0.7 9.2 0.8 1.8 9.2 0.6 0.6 10.5 1.0 14.5 9.5 20.1 0.8 0.0 18.6 14.2 15.2 0.3 1.5 9.6 1.3 0.6 11.6 8.2 2.8 0.1 0.9 1.3 4.3 1.2 1.4 0.5 2.5 0.2 0.3 1.7 0.6 2.1 0.0 0.6 2.5 5.8 2.3 0.4 0.1 1.3 0.2 0.0 0.3 1.5 2.2 4.3 0.8 12.3 0.4 3.2 0.3 0.0 1.4 0.6 0.3 0.4 0.2 4.9 0.1 0.0 0.3 0.6 3.3 0.8 1.6 1.3 2.0 1.1 1.1 2.5 1.5 4.6 0.2 0.5 0.4 2.3 2.8 2.6 1.7 2.0 0.4 1.2 0.2 0.1 0.7 4.8 0.8 3.1 0.5 1.9 5.6 0.4 1.2 0.3 0.6 0.4 0.3 1.2 0.1 0.3 0.2 2.2 0.7 0.9 0.2 0.3 0.2 2.2 3.0 28.4 5.4 3.8 0.0 0.0 0.4 1.8 0.0 0.3 2.8 44.1 0.0 7.4 152.8 21.4 16.4 29.3 10.8 14.2 10.1 21.2 21.8 21.6 25.8 7.2 25.8 31.3 7.7 12.4 26.4 92.0 32.3 80.6 13.6 8.7 30.3 9.6 3.4 625.8 47.1 4.6 13.1 14.8 11.8 80.7 13.7 19.6 97.2 47.0 16.8 318.6 20.8 4.1 33.6 48.3 167.9 9.3 38.0 30.2 85.3 22.3 14.6 11.3 268.9 60.7 51.1 37.8 9.8 16.2 33.8 195.5 666.1 5.6 6.2 13.1 11.3 16.9 39.3 26.5 20.1 14.1 8.3 18.0 14.1 24.5 31.1 MTR cblG ENSG00000116984 "5-methyltetrahydrofolate-homocysteine methyltransferase" Q99707 1 236795260-236921278 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Amino-acid biosynthesis, Methionine biosynthesis" "Methyltransferase, Transferase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 100.0;Glandular and luminal cells: 130.9;Inhibitory neurons: 106.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA044474, HPA054915" Approved Supported Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 24: NB-4 - Immune response" "Cluster 44: Endometrium - Transcription" Cytosol "HPA044474: AB_10966696, HPA054915: AB_2732589" "unprognostic (2.12e-1)" "unprognostic (1.03e-1)" "unprognostic (6.96e-2)" "unprognostic (1.99e-1)" "unprognostic (1.35e-1)" "unprognostic (1.76e-1)" "unprognostic (4.87e-1)" "unprognostic (1.02e-1)" "unprognostic (2.48e-2)" "unprognostic (3.34e-1)" "unprognostic (5.73e-2)" "unprognostic (1.63e-1)" "unprognostic (1.67e-2)" "unprognostic (8.84e-3)" "unprognostic (1.88e-1)" "prognostic unfavorable (5.75e-4)" "unprognostic (8.10e-2)" 9.1 6.6 4.3 6.9 5.4 4.6 8.0 5.2 5.4 10.1 6.5 11.1 4.8 10.2 10.5 5.0 11.9 8.9 15.0 4.9 4.6 12.7 6.0 7.1 8.1 6.7 5.3 14.6 13.0 20.2 6.4 11.6 6.9 7.6 5.0 5.6 6.4 9.1 16.6 9.3 7.1 8.7 4.8 9.4 9.0 9.0 4.8 10.0 13.4 18.1 7.0 10.3 7.6 6.5 17.6 11.0 13.0 8.8 22.6 20.3 15.3 14.9 14.8 18.8 19.0 12.6 12.5 40.0 13.2 16.6 8.7 10.6 18.4 13.1 20.4 19.8 13.7 23.7 14.2 18.3 15.1 37.2 13.3 28.9 7.0 22.9 17.9 11.5 22.3 19.8 33.1 16.4 13.1 10.1 19.6 10.3 16.2 12.9 5.4 20.9 24.8 24.2 11.2 21.3 11.1 27.8 17.7 11.9 14.8 9.3 16.7 13.0 28.8 24.1 9.1 19.6 18.8 34.4 12.3 22.7 17.2 21.1 26.2 0.6 0.5 1.5 1.1 0.8 2.3 0.7 1.4 1.4 0.7 0.8 1.4 1.5 0.0 0.9 0.5 0.5 0.9 0.9 4.3 5.4 5.2 5.4 4.9 4.6 6.7 5.3 6.9 4.8 4.8 6.5 23.0 57.7 35.0 53.8 25.8 8.2 8.3 8.3 17.1 0.0 10.7 11.9 100.0 20.0 10.9 40.5 0.0 24.2 25.9 3.4 1.9 13.8 9.8 57.5 80.1 21.4 8.4 23.5 87.7 14.8 9.2 22.8 15.8 130.9 30.4 35.0 15.4 10.8 14.4 0.0 106.8 7.7 4.1 16.6 6.8 6.2 23.9 17.1 10.6 47.8 15.3 0.0 19.6 62.8 73.6 12.3 8.0 33.1 20.3 14.9 9.7 9.1 13.3 0.0 6.6 39.4 23.2 17.2 22.0 11.5 5.1 22.6 26.1 40.2 12.0 6.4 MTRR cblE ENSG00000124275 "5-methyltetrahydrofolate-homocysteine methyltransferase reductase" Q9UBK8 5 7851186-7906025 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Amino-acid biosynthesis, Methionine biosynthesis" Oxidoreductase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 70.1;Late spermatids: 99.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA038113 Supported Approved "Nucleoplasm,Intermediate filaments,Cytosol" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 8: Non-specific - Mitochondria" "Cluster 20: HeLa - Mitochondria" "Cluster 11: Alveolar cells - Smell perception" "Nucleoplasm, Cytosol" "Intermediate filaments" "HPA038113: AB_10671520" "unprognostic (1.06e-1)" "unprognostic (1.08e-1)" "unprognostic (5.32e-2)" "unprognostic (1.17e-2)" "unprognostic (1.63e-1)" "unprognostic (2.43e-1)" "prognostic unfavorable (6.60e-4)" "unprognostic (2.56e-2)" "unprognostic (5.82e-2)" "unprognostic (7.43e-2)" "unprognostic (1.29e-1)" "unprognostic (9.11e-3)" "unprognostic (3.44e-2)" "unprognostic (1.30e-1)" "unprognostic (2.60e-1)" "unprognostic (1.56e-1)" "unprognostic (1.12e-1)" 11.2 10.6 5.1 9.5 11.2 5.7 6.3 10.1 10.9 7.2 3.4 8.3 8.9 11.7 12.3 9.3 9.6 11.8 14.4 6.5 9.0 18.7 19.4 13.1 11.1 10.9 10.4 11.4 11.9 12.8 6.7 10.8 10.6 9.0 10.1 19.2 10.5 7.1 28.9 9.1 10.2 12.0 8.2 6.7 6.7 7.1 9.3 7.5 9.0 32.9 10.6 14.4 5.5 20.0 19.3 18.1 10.2 20.0 34.0 13.6 25.1 31.1 18.5 16.5 15.4 27.8 15.1 32.6 27.9 24.6 27.4 11.8 17.0 14.2 27.9 22.9 15.8 14.6 62.0 15.3 21.9 23.4 6.8 18.3 11.4 24.6 18.4 20.4 10.4 8.0 21.9 24.2 9.8 4.2 14.2 11.7 7.3 29.4 19.0 12.4 9.5 14.1 16.2 16.0 14.0 2.5 51.6 33.7 28.6 18.1 10.7 17.5 14.6 31.9 19.7 24.1 22.7 34.7 13.5 27.3 23.1 50.5 19.1 5.3 4.0 3.0 4.1 5.5 7.0 3.3 6.5 5.7 3.6 3.3 4.1 3.6 0.1 3.1 4.4 2.3 9.1 3.3 5.1 11.2 10.1 10.9 6.5 9.0 10.9 10.4 10.6 8.2 9.3 20.0 7.7 16.0 70.1 10.1 11.1 16.3 9.4 4.6 12.0 0.0 9.7 5.1 12.9 5.7 9.0 9.2 0.0 9.9 11.4 11.0 21.5 10.2 50.1 10.0 10.7 8.0 9.6 12.4 25.4 5.5 8.9 11.8 9.2 6.7 10.2 6.5 8.6 19.3 7.7 0.0 20.8 9.1 0.0 11.1 9.4 99.2 10.5 9.7 1.8 15.0 8.1 0.0 7.2 20.1 50.9 7.2 6.0 11.7 26.5 14.3 8.7 28.9 10.1 0.0 6.6 10.7 10.1 17.4 13.1 10.5 20.6 11.2 13.8 11.8 9.4 8.7 MUL1 "C1orf166, FLJ12875, GIDE, MAPL, MULAN, RNF218" ENSG00000090432 "Mitochondrial E3 ubiquitin protein ligase 1" Q969V5 1 20499448-20508151 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026827 Approved Nucleoplasm,Mitochondria,Cytosol NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 47: Cytotrophoblasts - Unknown function" "Nucleoplasm, Mitochondria, Cytosol" "HPA026827: AB_10601137" "unprognostic (1.39e-1)" "unprognostic (2.73e-2)" "unprognostic (1.32e-2)" "unprognostic (1.51e-1)" "unprognostic (4.82e-3)" "unprognostic (1.85e-3)" "unprognostic (6.05e-3)" "unprognostic (1.01e-1)" "unprognostic (6.31e-2)" "unprognostic (5.86e-3)" "unprognostic (4.05e-1)" "unprognostic (9.10e-2)" "prognostic favorable (6.15e-14)" "unprognostic (1.59e-2)" "unprognostic (1.10e-1)" "unprognostic (1.05e-2)" "unprognostic (2.37e-1)" 16.7 18.1 18.1 12.0 18.7 28.8 16.2 19.9 19.4 15.9 23.3 21.2 14.2 20.4 11.1 21.2 19.6 14.9 33.7 17.8 19.4 19.5 24.6 15.8 13.6 20.3 19.1 19.1 19.8 36.3 14.6 16.3 20.1 16.0 15.7 7.4 19.3 20.0 35.5 21.8 15.8 20.0 18.7 15.2 18.7 12.2 19.5 12.0 16.2 50.4 15.0 19.2 15.5 19.9 34.1 32.1 18.1 37.9 38.5 21.6 19.6 32.9 39.1 40.1 38.2 19.9 54.8 25.4 35.9 46.8 30.4 50.3 32.9 47.5 28.9 25.4 26.1 19.4 20.4 29.2 45.2 27.0 32.0 35.3 61.6 41.1 42.3 23.4 26.5 22.5 25.8 30.1 44.1 17.3 16.4 18.1 18.7 28.1 30.3 15.8 22.8 32.9 47.1 18.7 18.4 27.3 29.6 31.2 40.5 14.6 22.0 25.6 30.2 38.8 22.3 34.1 29.9 34.9 32.9 27.3 30.4 36.1 36.7 36.2 30.0 38.2 33.1 34.7 34.4 25.3 24.8 33.8 29.6 22.8 28.1 27.6 26.7 32.3 30.7 22.8 37.9 34.0 18.1 18.7 19.9 19.4 17.8 19.4 20.3 19.1 20.1 18.7 19.5 19.9 14.5 22.4 10.3 10.4 9.8 5.2 9.2 13.9 5.2 13.5 12.3 11.9 16.6 10.0 9.5 18.4 6.2 37.1 13.2 21.6 11.7 26.3 2.2 7.7 9.5 13.1 8.5 8.6 4.9 23.4 22.5 13.9 7.7 9.4 3.8 14.7 13.6 17.6 23.0 13.5 6.8 12.9 16.2 10.0 6.5 4.0 13.1 9.3 19.6 2.8 15.5 16.0 16.5 5.5 6.0 25.6 14.6 15.4 13.1 9.2 13.2 10.6 9.6 11.9 19.7 11.9 14.7 14.6 15.4 7.4 7.1 37.6 9.2 18.0 12.2 10.7 MYCBP2 "FLJ10106, KIAA0916, PAM, PHR1" ENSG00000005810 "MYC binding protein 2" O75592 13 77044657-77327094 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Biological rhythms, Ubl conjugation pathway" "Guanine-nucleotide releasing factor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 425.4;Inhibitory neurons: 471.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HL-60: 110.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA058807 Supported Nucleoplasm,Vesicles,Cytosol "Intracellular and membrane" NA NA "Cluster 37: B-cells - Transcription" "Cluster 27: Brain & Skin - Unknown function" "Cluster 32: U-937 - Innate immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "Vesicles, Cytosol" "HPA058807: AB_2732627" "unprognostic (1.79e-1)" "unprognostic (1.25e-1)" "unprognostic (1.60e-1)" "unprognostic (1.06e-1)" "unprognostic (1.75e-1)" "unprognostic (2.03e-2)" "unprognostic (8.36e-2)" "unprognostic (1.21e-1)" "unprognostic (1.09e-1)" "unprognostic (1.80e-1)" "unprognostic (1.48e-1)" "unprognostic (6.42e-2)" "prognostic favorable (5.01e-5)" "unprognostic (2.63e-1)" "unprognostic (9.84e-2)" "unprognostic (4.04e-2)" "unprognostic (1.00e-1)" 69.9 22.2 42.3 19.0 46.2 32.8 49.3 37.3 52.4 43.4 18.8 29.4 9.0 27.2 29.8 45.9 29.2 12.5 32.9 48.6 35.9 22.6 24.5 28.3 40.0 34.6 29.6 43.1 30.9 14.9 32.3 10.9 36.9 28.0 12.5 28.9 29.1 13.3 26.5 79.7 34.8 11.9 30.1 56.4 24.9 26.3 33.9 34.6 27.2 18.1 37.8 30.4 41.5 38.7 21.6 10.8 12.9 14.1 62.9 27.9 7.5 13.4 19.8 11.5 14.7 9.7 11.0 61.4 8.3 26.6 11.2 19.5 22.4 24.7 15.5 24.5 22.2 52.2 22.2 20.1 21.4 110.8 17.7 31.5 20.2 10.6 20.8 11.4 26.5 22.3 11.3 18.8 20.7 13.1 30.5 74.3 6.8 28.7 13.6 34.2 13.1 15.0 19.6 21.1 20.2 9.4 16.2 23.1 12.8 13.0 8.6 83.8 35.0 10.9 9.1 7.3 13.0 20.3 15.0 42.7 22.1 89.2 11.3 1.4 2.0 2.0 3.2 2.1 2.8 4.9 3.6 2.8 1.9 4.3 4.1 3.2 1.8 2.8 1.6 2.7 4.5 1.4 42.3 46.2 37.3 52.4 48.6 35.9 34.6 29.6 36.9 30.1 33.9 38.7 92.2 38.5 52.2 158.7 170.3 82.3 39.9 32.6 63.7 229.3 36.8 38.4 69.7 25.8 30.9 35.0 104.3 46.1 109.2 14.2 1.9 26.1 56.0 50.9 61.1 83.8 32.6 46.9 425.4 33.1 31.5 80.6 38.2 66.6 48.2 34.0 44.6 52.4 41.8 218.7 471.3 19.7 26.4 106.9 48.2 23.4 65.9 100.4 32.0 282.9 116.7 121.5 120.5 338.8 212.5 30.2 15.8 96.3 121.9 53.7 15.2 13.2 19.5 94.8 105.2 76.7 76.0 81.5 71.6 129.1 150.7 43.9 121.5 67.4 28.1 42.4 MYLIP "IDOL, MIR" ENSG00000007944 "Myosin regulatory light chain interacting protein" Q8WY64 6 16129086-16148248 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Syncytiotrophoblasts: 352.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "RPMI-8226: 57.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 25: RPMI-8226 - Immune response" "Cluster 7: Non-specific - Mitochondria" "unprognostic (1.54e-1)" "unprognostic (4.84e-3)" "unprognostic (2.79e-1)" "unprognostic (9.65e-3)" "unprognostic (1.07e-1)" "unprognostic (2.07e-2)" "unprognostic (1.11e-2)" "prognostic favorable (6.44e-6)" "unprognostic (2.75e-2)" "unprognostic (2.67e-2)" "unprognostic (5.44e-3)" "unprognostic (1.03e-2)" "prognostic favorable (3.67e-4)" "unprognostic (1.42e-2)" "unprognostic (1.47e-1)" "unprognostic (2.35e-1)" "prognostic favorable (4.11e-5)" 37.0 18.9 12.8 12.8 20.0 92.1 30.2 12.5 16.4 42.2 13.6 24.3 12.9 40.3 30.6 18.1 32.6 21.3 14.2 13.4 13.3 21.6 4.9 29.5 22.8 13.7 14.3 35.8 15.5 24.6 8.2 63.4 12.0 16.4 16.5 4.7 25.7 23.1 41.1 25.7 24.5 28.4 12.3 30.8 22.7 15.0 15.7 15.2 50.2 22.8 15.4 25.0 24.7 22.4 3.4 6.0 2.8 3.3 28.3 6.9 7.3 2.4 5.4 5.4 12.0 18.4 3.3 16.0 11.5 3.9 4.0 8.2 13.0 4.4 4.9 5.2 12.8 10.2 7.1 3.8 4.1 7.4 10.0 11.5 5.5 2.6 2.2 2.8 12.5 3.4 29.8 18.6 2.1 12.6 0.2 40.6 8.0 8.4 5.7 3.5 12.9 57.9 6.7 40.0 13.5 6.2 2.9 31.2 17.1 23.9 5.8 18.8 3.5 2.6 6.2 2.2 6.1 16.0 7.5 8.1 1.6 20.9 9.0 6.1 1.5 7.8 5.8 1.8 5.4 4.2 3.7 4.1 1.1 3.3 4.0 3.9 9.4 2.6 1.5 0.5 2.3 1.2 12.8 20.0 12.5 16.4 13.4 13.3 13.7 14.3 12.0 12.3 15.7 22.4 102.6 22.4 50.2 5.5 67.7 98.0 38.9 8.8 126.3 9.3 67.6 117.0 90.7 50.1 17.7 22.0 0.0 134.2 78.5 49.5 9.8 22.1 47.5 82.7 56.2 70.9 84.3 52.6 17.1 18.4 80.0 79.6 54.0 77.7 35.5 35.1 41.4 1.4 32.0 11.8 8.4 41.1 10.2 61.7 121.2 20.2 38.5 56.0 80.0 7.5 27.3 16.9 56.7 3.0 55.3 7.6 32.4 61.7 30.2 28.1 27.8 21.1 25.7 7.8 138.1 90.8 96.7 53.0 22.6 100.9 84.0 352.3 103.8 3.9 45.4 35.1 MYLK "MLCK, MLCK1, MYLK1, smMLCK" ENSG00000065534 "Myosin light chain kinase" Q15746 3 123610049-123884332 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Actin-binding, Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Aortic aneurysm, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "seminal vesicle: 1700.3;smooth muscle: 2137.7" "Cell type enhanced" "Detected in many" "Breast myoepithelial cells: 728.5;Hepatocytes: 208.7;Peritubular cells: 690.5;Sertoli cells: 276.1;Smooth muscle cells: 448.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "basophil: 7.4" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "BJ: 200.0;BJ hTERT+: 298.2;fHDF/TERT166: 260.2;hTERT-RPE1: 202.7;RPTEC TERT1: 291.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB020789, HPA031677, HPA048055" Enhanced Enhanced "Plasma membrane,Actin filaments" NA NA 1500000 "Cluster 34: Basophils - Unknown function" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 48: Smooth muscle cells - ECM organization" "Actin filaments" "Plasma membrane" "CAB020789: , HPA031677: AB_10794617, HPA048055: AB_2732543" "unprognostic (2.80e-2)" "unprognostic (5.05e-2)" "unprognostic (5.55e-2)" "unprognostic (2.85e-2)" "unprognostic (1.69e-1)" "unprognostic (1.41e-1)" "unprognostic (4.86e-2)" "unprognostic (8.55e-2)" "unprognostic (1.20e-1)" "unprognostic (1.40e-1)" "unprognostic (8.21e-2)" "unprognostic (1.58e-1)" "prognostic unfavorable (2.04e-6)" "unprognostic (5.26e-3)" "unprognostic (9.60e-2)" "unprognostic (3.00e-1)" "prognostic unfavorable (4.46e-4)" 143.6 57.4 37.6 188.7 64.8 3.3 163.4 72.1 42.4 281.3 14.1 551.5 110.9 669.2 232.9 420.6 289.8 250.4 33.6 33.6 46.7 64.4 67.2 85.2 33.6 104.6 64.8 95.9 15.3 11.6 2.6 70.2 99.3 907.6 299.1 13.6 140.1 1700.3 10.0 20.1 125.1 2137.7 55.6 89.5 122.7 50.5 52.2 8.0 22.2 14.9 19.1 505.7 84.8 112.1 14.4 38.4 10.8 7.8 10.8 1.9 4.7 200.0 298.2 137.3 92.1 8.1 7.4 0.6 42.5 260.2 67.0 4.8 5.2 1.8 149.0 0.2 0.7 102.4 0.9 28.9 56.1 0.6 9.8 36.9 3.5 24.4 34.4 202.7 8.9 1.3 1.2 0.5 90.9 1.7 0.2 2.5 12.0 0.5 5.1 13.5 6.8 36.7 291.9 8.5 1.4 6.4 21.8 1.9 3.1 25.0 1.0 0.3 33.4 39.5 13.9 10.3 30.7 3.4 4.2 0.3 104.0 1.0 9.6 7.4 1.6 0.4 0.1 0.2 0.0 0.2 0.0 0.0 3.5 0.1 0.2 0.1 5.0 0.0 0.0 3.3 0.2 20.9 37.6 64.8 72.1 42.4 33.6 46.7 104.6 64.8 99.3 55.6 52.2 112.1 45.9 16.0 38.3 43.4 2.5 20.5 27.2 24.8 1.2 2.9 19.9 728.5 25.2 37.1 5.7 27.6 125.1 0.8 3.5 88.1 3.9 6.0 40.7 45.9 46.6 56.9 11.4 3.2 25.2 3.9 0.8 40.1 3.1 54.4 2.5 3.2 45.3 208.7 4.9 3.3 3.4 3.9 8.2 7.9 37.0 33.8 104.7 20.8 19.6 8.4 1.2 4.7 0.0 5.5 37.0 4.0 18.7 690.5 3.3 8.6 14.2 17.2 17.6 19.9 276.1 5.6 448.7 4.7 4.6 1.3 20.2 2.5 3.2 4.5 4.2 3.7 MYLK2 "KMLC, MLCK2, skMLCK" ENSG00000101306 "Myosin light chain kinase 2" Q9H1R3 20 31819308-31834689 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cardiomyopathy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 12 "skeletal muscle: 732.0" "Cell type enriched" "Detected in some" 5 "Skeletal myocytes: 15.9" "Cancer enhanced" "Detected in some" "glioma: 1.6" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "Karpas-707: 4.1;RH-30: 10.5;RPMI-8226: 8.8" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA059704, HPA059890" Enhanced Supported "Endoplasmic reticulum" NA NA "Cluster 33: Striated muscle - Muscle contraction" "Cluster 25: RPMI-8226 - Immune response" "Cluster 37: Myocytes - Muscle contraction" "Endoplasmic reticulum" "HPA059704: AB_2684108, HPA059890: AB_2684153" "unprognostic (1.74e-2)" "unprognostic (1.87e-1)" "unprognostic (8.84e-2)" "unprognostic (5.27e-2)" "prognostic favorable (4.00e-4)" "unprognostic (5.58e-2)" "unprognostic (1.38e-7)" "unprognostic (2.29e-1)" "unprognostic (2.60e-3)" "unprognostic (1.99e-1)" "unprognostic (1.20e-1)" "unprognostic (4.73e-2)" "unprognostic (7.25e-11)" "unprognostic (2.01e-1)" "unprognostic (3.15e-1)" "unprognostic (2.60e-2)" "unprognostic (2.70e-2)" 0.1 0.0 0.6 0.1 0.6 0.4 0.1 0.6 0.7 0.0 0.5 0.2 0.0 0.1 0.1 4.7 0.1 0.0 0.3 0.6 0.6 0.0 0.0 0.1 0.0 0.6 0.7 0.1 5.5 0.0 0.1 0.0 0.7 1.1 0.0 0.0 2.4 0.0 732.0 0.6 0.1 0.1 0.6 0.3 0.2 0.2 0.7 0.2 0.2 60.3 0.0 0.0 0.0 0.6 0.3 0.0 0.7 0.6 0.0 0.0 0.4 0.1 0.0 0.3 0.0 0.2 0.2 0.5 0.3 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.6 0.3 0.0 0.0 0.5 0.1 0.0 0.0 0.3 0.0 1.3 0.8 0.5 0.1 4.1 0.1 0.6 0.5 0.3 0.5 0.0 0.3 0.6 10.5 8.8 0.0 0.1 0.5 0.5 2.7 0.1 0.0 0.1 0.1 0.1 2.1 0.2 0.7 0.4 2.4 0.0 0.8 0.2 0.1 2.5 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.6 0.6 0.7 0.6 0.6 0.6 0.7 0.7 0.6 0.7 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 1.2 0.0 0.0 0.1 0.4 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 1.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 2.8 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.9 0.3 0.3 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 MYLK3 "caMLCK, MLCK" ENSG00000140795 "Myosin light chain kinase 3" Q32MK0 16 46702282-46790407 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "heart muscle: 103.4;skeletal muscle: 46.5;tongue: 72.6" "Group enriched" "Detected in some" 12 "Cardiomyocytes: 169.0;Endometrial ciliated cells: 44.8" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 12.9;HEL: 40.2;K-562: 6.5;SK-BR-3: 7.9" "Group enriched" "Detected in some" 7 "cerebral cortex: 9.6;hippocampal formation: 5.1" "Region enriched" "Detected in single" 5 "hippocampal formation: 3.5" HPA073447 Enhanced Approved Nucleoplasm,Vesicles NA NA "Cluster 38: Heart - Muscle contraction" "Cluster 36: HEL - Hemostasis" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm Vesicles "HPA073447: AB_2732225" "unprognostic (6.01e-4)" "unprognostic (2.19e-1)" "unprognostic (2.64e-1)" "unprognostic (1.77e-2)" "unprognostic (1.84e-1)" "unprognostic (2.94e-3)" "unprognostic (2.60e-1)" "unprognostic (4.73e-2)" "unprognostic (3.33e-2)" "unprognostic (2.41e-2)" "unprognostic (6.58e-3)" "unprognostic (1.83e-1)" "unprognostic (4.16e-2)" "unprognostic (2.57e-2)" "unprognostic (2.52e-1)" "unprognostic (1.08e-2)" "unprognostic (2.97e-1)" 0.0 0.1 1.9 0.1 1.7 0.3 0.1 1.1 2.3 0.4 1.7 0.0 0.1 0.3 0.8 4.3 1.7 0.2 103.4 2.5 2.8 1.1 0.1 0.4 0.2 9.8 12.2 0.3 0.1 0.0 0.4 0.5 8.2 2.2 0.1 0.2 2.1 0.1 46.5 0.1 0.1 0.2 5.9 0.1 0.1 6.0 1.9 0.1 0.1 72.6 0.1 0.0 0.0 3.0 0.0 0.1 0.1 0.1 0.0 0.0 12.9 0.0 0.0 0.0 0.0 0.8 0.2 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 40.2 2.0 0.1 0.1 0.1 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.1 6.5 0.3 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.4 0.4 0.0 7.9 0.2 3.5 0.2 0.1 0.1 0.1 0.1 0.1 0.0 0.5 0.1 0.3 0.0 0.1 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 1.9 1.7 1.1 2.3 2.5 2.8 9.8 12.2 8.2 5.9 1.9 3.0 0.2 0.0 3.3 0.7 0.5 0.0 0.7 0.0 0.0 0.9 1.3 0.0 169.0 0.0 3.7 0.0 2.1 2.0 0.2 0.0 0.0 0.0 8.1 44.8 7.1 1.7 0.0 0.0 0.9 0.2 0.5 6.7 0.0 2.2 1.3 1.6 0.7 0.1 0.4 0.0 0.6 0.0 0.0 0.0 0.0 7.2 0.6 0.8 0.0 0.0 0.2 0.8 0.0 0.0 0.2 0.1 0.0 0.0 0.3 0.8 0.0 0.2 8.7 1.3 0.0 4.9 2.7 1.0 0.7 0.0 0.0 0.3 0.8 0.7 0.0 0.8 MYLK4 SgK085 ENSG00000145949 "Myosin light chain kinase family member 4" Q86YV6 6 2663629-2750922 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 17 "skeletal muscle: 30.1;tongue: 72.1" "Cell type enhanced" "Detected in some" "Excitatory neurons: 7.8;Inhibitory neurons: 7.2;Microglial cells: 4.7;Oligodendrocyte precursor cells: 8.0;Proximal tubular cells: 4.5" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 7 "HEL: 7.2" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA015860 Uncertain Approved "Nucleoli,Golgi apparatus,Vesicles" NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 36: HEL - Hemostasis" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Golgi apparatus" "Nucleoli, Vesicles" "HPA015860: AB_2147922" "unprognostic (1.75e-1)" "unprognostic (2.04e-1)" "unprognostic (1.87e-1)" "unprognostic (5.22e-3)" "unprognostic (1.85e-1)" "unprognostic (2.99e-2)" "unprognostic (7.48e-2)" "unprognostic (2.80e-1)" "unprognostic (5.32e-2)" "unprognostic (2.25e-1)" "unprognostic (2.02e-2)" "unprognostic (2.91e-1)" "unprognostic (2.74e-3)" "unprognostic (1.43e-1)" "unprognostic (2.65e-1)" "unprognostic (1.19e-2)" "unprognostic (4.63e-2)" 1.2 0.5 0.6 0.3 0.6 0.8 1.0 0.6 0.9 0.6 0.7 0.4 0.3 0.6 0.7 1.3 0.5 0.4 1.4 0.7 0.7 3.0 0.5 1.2 0.4 0.4 0.5 0.4 0.9 0.9 1.3 0.6 0.4 0.7 0.3 0.8 2.4 0.6 30.1 1.4 0.6 0.3 0.4 0.6 0.6 0.4 0.6 0.3 0.8 72.1 0.7 0.6 0.8 0.6 0.1 0.1 0.3 0.6 0.5 0.6 0.3 0.4 0.8 0.2 0.2 0.3 0.6 0.6 0.9 0.4 0.1 1.0 0.1 0.2 0.3 0.1 0.3 7.2 0.4 0.0 0.2 0.2 0.3 0.8 0.3 0.0 0.6 0.3 0.3 0.1 0.0 0.0 0.1 0.3 0.0 0.8 0.1 0.2 0.0 0.5 0.0 0.0 0.4 0.1 0.5 0.3 0.1 0.1 0.3 0.5 0.2 0.5 0.4 0.2 0.0 0.1 0.2 0.2 0.1 0.0 0.1 0.2 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.6 0.6 0.9 0.7 0.7 0.4 0.5 0.4 0.4 0.6 0.6 0.5 3.2 1.1 1.6 0.5 0.1 0.1 0.5 0.6 1.0 0.6 0.3 1.9 1.5 1.0 0.0 0.0 0.3 0.1 0.2 0.0 0.3 0.4 0.1 0.7 0.6 1.2 0.0 7.8 0.2 0.0 0.5 0.0 0.2 0.0 0.6 1.1 0.2 0.3 1.7 7.2 0.0 0.0 0.8 1.2 0.2 0.3 0.4 0.0 4.7 1.1 0.3 0.0 8.0 2.9 0.0 0.0 1.5 0.0 0.2 0.1 4.5 0.3 0.3 0.0 0.8 0.3 0.0 0.3 0.3 0.9 0.3 0.2 0.4 0.3 0.2 MYO3A DFNB30 ENSG00000095777 "Myosin IIIA" Q8NEV4 10 25934229-26212532 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hearing, Sensory transduction, Vision" "Actin-binding, Kinase, Motor protein, Myosin, Serine/threonine-protein kinase, Transferase" "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "retina: 15.5;testis: 5.2" "Cell type enhanced" "Detected in some" "Early spermatids: 156.6;Late spermatids: 58.2;Muller glia cells: 74.8;Spermatocytes: 31.7" "Cancer enhanced" "Detected in many" "cervical cancer: 1.7" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 1.3;CAPAN-2: 1.2;HEK 293: 1.5;SCLC-21H: 1.4;U-2 OS: 2.4;U-698: 6.3" "Not detected" "Not detected" "HPA051893, HPA075413" Enhanced Supported "Plasma membrane,Actin filaments,Cytoplasmic bodies" No No "Cluster 77: Retina - Visual perception" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 5: Muller glia cells - Visual perception" "Actin filaments, Cytoplasmic bodies" "Plasma membrane" "HPA051893: , HPA075413: " "unprognostic (5.00e-3)" "unprognostic (3.36e-2)" "unprognostic (1.53e-1)" "unprognostic (3.20e-3)" "unprognostic (2.96e-1)" "unprognostic (4.37e-2)" "unprognostic (5.29e-2)" "unprognostic (2.74e-1)" "unprognostic (4.31e-2)" "unprognostic (1.03e-1)" "unprognostic (5.66e-3)" "unprognostic (7.96e-3)" "unprognostic (6.34e-2)" "unprognostic (1.46e-2)" "unprognostic (6.62e-2)" "unprognostic (9.69e-2)" 0.1 0.1 0.4 0.0 1.8 0.1 0.1 0.0 0.8 0.1 0.2 0.1 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.1 0.6 0.3 0.0 0.1 0.0 0.6 0.5 0.0 0.7 0.0 0.5 0.0 0.5 0.1 0.3 15.5 0.0 0.1 0.0 0.7 0.1 0.0 0.2 0.0 0.2 5.2 0.3 0.2 0.2 0.1 0.2 0.0 0.3 0.3 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.9 0.8 0.0 0.0 0.7 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 6.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 1.8 0.0 0.8 0.1 0.6 0.6 0.5 0.5 0.2 0.3 0.3 0.2 0.0 0.5 2.0 0.1 1.8 0.3 0.0 0.0 0.9 0.6 0.3 0.6 0.0 2.5 0.0 0.0 0.0 0.0 0.2 1.9 0.8 156.6 0.6 0.1 0.3 1.8 0.0 2.2 0.0 0.4 0.6 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 5.9 0.4 0.0 0.0 0.0 58.2 1.2 0.1 0.0 1.9 0.0 74.8 0.0 1.0 0.4 0.2 0.0 1.2 0.0 0.3 0.0 1.0 0.0 3.9 0.0 0.0 2.4 31.7 14.2 2.4 1.0 0.0 0.0 0.0 0.4 0.3 MYO3B ENSG00000071909 "Myosin IIIB" Q8WXR4 2 170178145-170655171 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hearing, Sensory transduction, Vision" "Actin-binding, Kinase, Motor protein, Myosin, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "epididymis: 14.1;kidney: 5.3;parathyroid gland: 8.8;retina: 5.8" "Cell type enhanced" "Detected in some" "Cone photoreceptor cells: 85.5;Early spermatids: 34.2;Inhibitory neurons: 18.3;Late spermatids: 29.6;Rod photoreceptor cells: 51.0" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 9 "HDLM-2: 11.2;HEL: 8.8;RT4: 11.7" "Region enriched" "Detected in some" 5 "basal ganglia: 5.2" "Not detected" "Not detected" HPA045483 Approved NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 36: HEL - Hemostasis" "Cluster 9: Photoreceptor cells - Phototransduction" "HPA045483: AB_2679344" "unprognostic (1.65e-1)" "unprognostic (7.87e-2)" "unprognostic (1.96e-2)" "unprognostic (1.43e-2)" "unprognostic (1.67e-1)" "unprognostic (7.15e-3)" "unprognostic (5.07e-2)" "unprognostic (2.61e-2)" "unprognostic (5.84e-3)" "unprognostic (2.12e-1)" "unprognostic (7.99e-3)" "unprognostic (2.59e-1)" "unprognostic (4.25e-5)" "unprognostic (2.34e-1)" "unprognostic (8.12e-3)" "unprognostic (1.18e-1)" "unprognostic (1.07e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.6 0.0 0.0 0.0 0.1 14.1 0.4 0.6 0.1 0.0 0.0 0.3 5.3 0.0 0.0 0.0 0.0 0.0 0.0 0.5 8.8 0.3 0.0 0.0 0.0 0.0 5.8 0.1 1.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.9 0.0 0.4 1.3 0.0 0.1 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.3 0.0 0.0 11.2 0.0 8.8 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.8 0.1 0.0 0.0 0.0 0.0 1.1 11.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 1.3 0.3 0.6 0.5 0.3 0.0 3.1 0.2 0.3 0.7 0.0 0.5 3.7 85.5 0.0 0.6 0.1 13.7 0.3 34.2 5.3 0.4 0.3 1.8 0.0 1.8 0.0 0.0 0.8 0.0 1.7 0.0 0.1 0.0 0.2 0.0 0.0 18.3 0.6 0.0 0.3 1.1 29.6 0.3 0.2 0.0 1.9 0.0 3.0 0.0 5.5 2.9 0.1 0.0 0.4 0.0 0.2 0.0 0.2 0.2 51.0 0.0 1.7 0.5 1.5 0.8 0.3 0.4 0.1 0.3 0.3 0.0 0.1 NAGPA "APAA, UCE" ENSG00000103174 "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase" Q9UK23 16 5024844-5034141 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 29.6" "Cell type enhanced" "Detected in many" "Excitatory neurons: 44.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Hep G2: 53.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA064055 Approved NA NA 7800000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 65: Brain - Ion transport" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 52: Non-specific - Transcription" "HPA064055: AB_2685183" "unprognostic (9.93e-2)" "unprognostic (1.61e-2)" "unprognostic (2.08e-2)" "unprognostic (2.21e-2)" "unprognostic (7.12e-3)" "unprognostic (3.30e-3)" "prognostic unfavorable (4.67e-4)" "unprognostic (1.05e-2)" "unprognostic (2.98e-2)" "unprognostic (1.35e-1)" "unprognostic (9.51e-3)" "unprognostic (9.41e-2)" "prognostic unfavorable (2.67e-5)" "unprognostic (1.26e-1)" "unprognostic (6.09e-2)" "unprognostic (7.47e-2)" "unprognostic (1.02e-1)" 6.3 7.0 20.3 5.7 21.6 6.2 5.5 17.9 29.6 5.5 17.6 8.8 6.5 6.6 2.6 6.4 4.8 3.4 5.4 23.6 18.3 8.2 9.0 5.7 6.4 19.2 18.0 3.6 6.2 4.8 5.4 4.1 18.5 5.7 3.0 0.6 5.4 3.3 6.1 6.7 9.8 3.4 17.8 11.8 9.4 3.3 19.6 3.5 5.7 2.4 2.8 6.4 5.1 20.9 2.5 9.7 1.6 10.4 4.0 5.0 10.8 7.1 12.7 9.3 11.2 8.0 19.9 1.0 8.8 9.6 15.8 7.3 4.4 7.8 2.6 11.8 13.3 3.6 5.7 53.1 12.7 8.8 14.6 7.7 8.1 6.0 2.7 11.0 14.6 8.8 11.5 14.1 5.5 11.3 4.0 23.6 5.0 6.3 10.2 10.4 3.7 19.3 5.8 3.9 4.0 5.6 5.6 14.2 15.1 1.4 9.7 10.5 11.0 9.9 7.2 24.0 5.3 6.9 6.3 2.3 4.6 13.1 8.3 3.9 39.3 10.4 17.9 35.0 14.2 17.3 17.1 15.4 50.5 14.2 14.0 13.2 1.2 10.6 23.6 12.9 16.3 20.1 20.3 21.6 17.9 29.6 23.6 18.3 19.2 18.0 18.5 17.8 19.6 20.9 8.1 0.0 2.7 7.8 15.0 2.9 4.7 4.5 7.4 14.7 5.2 5.1 3.1 8.6 4.7 5.5 31.3 13.3 10.2 21.8 1.9 11.3 0.4 3.0 3.7 8.4 1.2 9.1 44.5 8.5 14.9 4.6 28.1 4.1 1.3 8.9 9.7 7.7 27.2 16.8 21.5 13.6 2.0 24.9 8.6 1.0 8.1 20.6 3.6 2.8 24.0 4.5 18.6 4.0 6.9 9.5 18.4 6.4 13.2 4.1 28.9 9.0 3.2 13.8 0.0 4.3 4.8 4.4 8.4 8.8 2.4 9.4 12.1 5.8 12.4 3.2 NAT1 AAC1 ENSG00000171428 "N-acetyltransferase 1" P18440 8 18170477-18223689 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 24.2;Paneth cells: 32.7;Respiratory ciliated cells: 32.0" "Cancer enriched" "Detected in all" 14 "breast cancer: 47.9" "Low region specificity" "Detected in some" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "CAB017782, HPA043704" Approved NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 9: Intestine - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB017782: , HPA043704: AB_2678625" "unprognostic (1.31e-1)" "unprognostic (1.05e-1)" "prognostic favorable (5.07e-4)" "unprognostic (2.09e-1)" "unprognostic (2.53e-2)" "unprognostic (8.25e-2)" "unprognostic (5.20e-2)" "unprognostic (6.53e-2)" "unprognostic (6.75e-2)" "unprognostic (1.27e-1)" "unprognostic (1.37e-2)" "unprognostic (9.51e-2)" "unprognostic (6.60e-2)" "unprognostic (7.44e-2)" "unprognostic (2.30e-1)" "unprognostic (3.28e-2)" "unprognostic (8.15e-2)" 3.6 1.5 0.5 5.4 0.7 3.2 5.9 0.8 0.9 6.5 0.8 14.2 11.7 2.4 15.2 2.5 4.4 3.6 1.8 0.5 0.7 5.7 10.4 3.5 6.0 1.2 0.7 2.9 1.8 1.1 1.0 4.1 0.8 7.3 12.8 0.3 1.9 2.9 0.4 2.4 8.9 3.6 0.8 4.1 4.9 1.8 0.8 4.6 2.1 1.5 6.7 4.5 1.3 1.0 22.6 2.7 2.5 3.3 6.3 6.3 5.3 8.0 8.5 8.8 10.2 4.0 4.7 11.0 6.2 5.2 8.1 3.6 4.5 5.4 8.9 10.3 2.3 7.6 3.0 3.0 6.0 3.3 9.7 5.2 6.5 6.0 0.5 2.2 7.9 9.3 6.6 2.9 10.0 4.0 9.8 10.3 2.4 17.8 3.4 4.9 2.5 4.3 9.3 12.6 1.3 1.7 0.3 9.5 5.5 5.2 7.7 9.7 8.5 5.3 3.1 8.0 1.3 2.0 4.0 9.3 4.6 7.5 2.4 5.4 4.6 9.4 3.3 5.3 2.4 4.4 3.4 3.4 6.1 3.9 3.2 3.9 8.2 6.3 5.4 3.5 6.3 2.7 0.5 0.7 0.8 0.9 0.5 0.7 1.2 0.7 0.8 0.8 0.8 1.0 4.6 0.0 3.6 0.7 4.7 0.4 0.8 9.1 1.2 0.0 3.5 1.9 1.6 0.0 11.3 5.5 0.0 5.9 2.3 24.2 1.9 5.7 10.8 3.9 3.2 3.0 3.6 0.8 0.8 6.9 7.7 2.1 3.6 2.8 2.5 1.1 2.2 12.7 7.2 0.0 0.2 10.7 8.2 6.3 2.6 2.2 4.1 5.3 3.6 1.9 4.9 2.5 4.1 0.0 0.5 5.8 32.7 5.7 2.6 2.3 12.7 16.6 32.0 0.0 0.0 0.7 3.4 4.2 0.6 2.2 0.6 10.9 4.1 3.2 8.4 2.5 NAT2 AAC2 ENSG00000156006 "N-acetyltransferase 2" P11245 8 18391282-18401218 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 41 "intestine: 33.5;liver: 128.6" "Group enriched" "Detected in some" 4 "Distal enterocytes: 14.8;Hepatocytes: 59.0;Paneth cells: 15.9;Proximal enterocytes: 36.0" "Cancer enhanced" "Detected in some" "colorectal cancer: 4.0;liver cancer: 4.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "RPTEC TERT1: 1.0;RT4: 1.6;SCLC-21H: 2.2;SK-BR-3: 1.4" HPA043704 Uncertain NA NA "Cluster 85: Liver - Metabolism" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 2: Hepatocytes - Metabolism" "HPA043704: AB_2678625" "unprognostic (2.74e-3)" "unprognostic (4.03e-1)" "prognostic favorable (4.61e-5)" "unprognostic (1.43e-2)" "unprognostic (1.07e-1)" "unprognostic (1.83e-1)" "unprognostic (2.52e-2)" "unprognostic (2.67e-2)" "unprognostic (1.27e-1)" "unprognostic (1.33e-2)" "unprognostic (4.07e-1)" "unprognostic (6.05e-3)" "unprognostic (1.02e-1)" "unprognostic (3.40e-1)" "unprognostic (1.83e-1)" "unprognostic (1.64e-1)" 0.1 0.1 0.2 1.6 0.2 0.0 1.1 0.2 0.6 0.5 0.1 15.0 33.5 0.9 0.7 0.1 0.2 0.2 0.2 0.2 0.2 1.9 128.6 0.2 0.0 0.2 0.2 0.2 0.0 0.0 0.1 0.6 0.1 0.4 13.2 0.0 0.0 0.5 0.0 0.0 25.6 1.6 0.2 1.3 0.1 0.4 0.2 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.1 0.0 0.6 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.1 0.0 0.2 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.3 0.0 1.0 1.6 2.2 0.0 0.0 1.4 0.0 0.1 0.3 0.2 0.5 0.3 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.2 0.6 0.2 0.2 0.2 0.2 0.1 0.2 0.2 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.3 0.0 0.0 1.0 0.0 14.8 5.9 0.1 0.1 0.0 0.2 0.1 0.0 0.0 0.1 0.0 1.0 0.1 0.0 0.0 0.0 0.0 0.4 59.0 0.2 0.0 0.0 7.4 0.0 1.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 15.9 2.6 0.0 0.0 36.0 0.8 0.3 0.0 0.0 0.3 0.1 0.3 0.0 0.0 0.0 4.4 0.1 0.8 6.7 0.1 NCOA1 "bHLHe74, F-SRC-1, KAT13A, NCoA-1, RIP160, SRC1" ENSG00000084676 "Nuclear receptor coactivator 1" Q15788 2 24491914-24770702 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Acyltransferase, Transferase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 467.5;Excitatory neurons: 313.0;Inhibitory neurons: 421.8;Microglial cells: 341.9;Oligodendrocyte precursor cells: 459.4;Oligodendrocytes: 305.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RH-30: 81.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB019402, HPA070213, HPA070520" Supported Enhanced "Nucleoplasm,Plasma membrane,Cytosol" No No "Cluster 5: Granulocytes - Unknown function" "Cluster 58: Brain - Synaptic function" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "Plasma membrane, Cytosol" "CAB019402: AB_2196189, HPA070213: AB_2686235, HPA070520: AB_2686276" "unprognostic (2.73e-1)" "unprognostic (5.82e-2)" "unprognostic (2.46e-2)" "unprognostic (9.89e-3)" "unprognostic (7.60e-2)" "unprognostic (2.36e-2)" "unprognostic (7.06e-3)" "unprognostic (1.45e-1)" "unprognostic (1.43e-1)" "unprognostic (1.72e-1)" "unprognostic (2.93e-3)" "unprognostic (1.16e-1)" "unprognostic (2.10e-2)" "unprognostic (7.15e-2)" "unprognostic (3.08e-1)" "unprognostic (1.29e-1)" "unprognostic (2.92e-2)" 16.6 15.1 24.0 13.3 25.4 17.3 17.3 24.6 28.2 18.6 13.6 15.9 20.9 19.0 12.8 17.6 15.7 14.0 15.3 29.6 19.5 18.9 15.0 16.0 15.3 17.7 19.2 26.6 17.4 30.0 16.6 17.1 16.0 15.2 16.6 47.3 16.0 20.2 33.4 15.7 18.9 19.0 19.5 16.3 12.5 19.9 21.8 26.1 11.8 36.1 16.3 14.9 15.5 22.3 14.1 10.3 17.7 9.2 19.2 17.3 26.9 7.4 14.7 9.1 8.1 9.6 5.9 10.2 3.1 13.5 17.4 3.4 10.7 6.3 9.8 48.6 15.5 36.5 4.1 4.1 12.0 16.9 29.1 27.9 9.4 8.8 7.1 11.3 9.4 12.9 22.6 16.5 14.0 9.4 15.1 6.0 8.5 8.2 6.8 11.8 81.5 5.1 9.9 18.9 16.2 12.8 17.1 10.2 7.4 9.3 12.3 8.6 10.2 15.2 11.9 10.5 7.5 18.8 17.5 17.2 8.6 10.5 7.7 10.6 3.3 7.0 3.4 2.6 3.8 1.6 3.0 3.8 2.5 2.4 2.9 3.5 13.8 3.5 2.9 5.2 3.7 2.0 24.0 25.4 24.6 28.2 29.6 19.5 17.7 19.2 16.0 19.5 21.8 22.3 41.0 38.5 31.5 467.5 16.7 30.5 11.6 7.8 14.2 96.5 32.3 26.7 41.9 17.2 22.8 14.7 52.1 13.1 47.0 39.0 7.9 16.5 29.7 14.6 37.6 34.9 25.2 29.9 313.0 26.6 18.1 39.8 19.9 28.4 20.2 52.9 36.8 22.8 17.9 62.2 421.8 20.7 20.3 29.8 30.3 7.4 47.2 37.7 19.6 341.9 34.7 66.7 78.2 459.4 305.8 20.1 33.5 43.2 14.3 15.7 30.4 12.5 16.9 71.6 39.5 116.9 34.4 37.7 37.6 16.6 31.0 5.3 33.4 27.2 24.1 21.7 NCOA2 "bHLHe75, GRIP1, KAT13C, NCoA-2, TIF2" ENSG00000140396 "Nuclear receptor coactivator 2" Q15596 8 70109782-70403808 "Cancer-related genes, Disease related genes, Metabolic proteins, Predicted intracellular proteins, Transcription factors" "Biological rhythms, Transcription, Transcription regulation" Activator "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 161.6;Excitatory neurons: 158.9;Inhibitory neurons: 314.8;Microglial cells: 233.3;Oligodendrocyte precursor cells: 249.8;Oligodendrocytes: 186.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA060243 Supported "Nucleoplasm,Nuclear bodies" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 34: Non-specific - Transcription" "Cluster 29: U-266 - Adaptive immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Nuclear bodies" "HPA060243: AB_2684229" "unprognostic (9.79e-3)" "unprognostic (1.40e-1)" "unprognostic (2.72e-1)" "unprognostic (4.94e-3)" "unprognostic (1.91e-2)" "unprognostic (2.18e-3)" "unprognostic (1.30e-1)" "unprognostic (6.77e-2)" "unprognostic (2.06e-1)" "unprognostic (7.00e-2)" "unprognostic (2.20e-2)" "unprognostic (2.63e-2)" "prognostic favorable (5.08e-4)" "unprognostic (2.52e-1)" "unprognostic (3.35e-1)" "unprognostic (1.07e-1)" "unprognostic (1.76e-1)" 8.4 8.9 8.9 9.9 10.5 23.3 13.4 8.9 10.0 10.0 1.5 10.6 11.6 10.1 29.6 15.3 10.9 8.9 15.0 13.6 13.2 14.4 23.8 10.0 11.6 8.0 6.8 16.2 7.3 15.2 7.3 12.1 7.7 12.9 10.6 26.1 11.3 12.1 8.3 10.5 12.1 9.0 4.6 12.4 10.9 14.7 9.9 15.3 12.1 15.9 12.5 10.0 9.9 6.1 13.7 16.9 18.2 10.3 16.2 16.5 18.6 7.8 7.8 5.9 5.5 8.6 15.6 16.3 3.1 14.3 9.7 8.0 22.5 10.7 6.5 38.7 17.9 28.5 8.5 13.8 8.5 5.8 7.2 14.5 11.7 7.9 11.3 9.2 4.0 11.7 9.2 24.0 6.9 13.7 14.5 5.8 9.6 15.7 7.9 14.1 7.6 10.3 9.3 22.5 13.8 10.2 13.4 7.1 11.0 12.7 16.7 10.5 5.3 8.4 10.6 10.8 4.2 31.5 17.3 15.4 8.6 7.6 12.5 3.1 1.6 2.2 2.2 2.3 1.5 1.3 1.3 1.9 1.5 2.1 1.5 1.6 5.7 1.4 5.2 0.6 2.0 1.2 8.9 10.5 8.9 10.0 13.6 13.2 8.0 6.8 7.7 4.6 9.9 6.1 20.9 12.8 25.1 161.6 27.3 16.2 8.6 10.8 17.6 25.8 29.5 17.5 34.1 28.6 25.8 25.8 52.1 22.1 26.9 30.8 11.7 9.3 6.4 23.6 26.4 17.7 25.2 28.8 158.9 12.4 12.5 21.6 21.4 38.0 22.2 23.2 22.1 65.9 17.4 74.0 314.8 17.4 10.2 46.8 17.8 7.6 19.9 28.1 21.4 233.3 23.1 14.3 19.6 249.8 186.0 12.8 14.8 22.2 49.9 15.5 22.7 17.6 19.0 33.4 26.3 22.5 20.2 13.3 16.5 18.8 21.5 31.7 36.6 10.9 17.0 15.8 NCOA3 "ACTR, AIB1, bHLHe42, CAGH16, KAT13B, p/CIP, RAC3, SRC-3, SRC3, TNRC16, TRAM-1" ENSG00000124151 "Nuclear receptor coactivator 3" Q9Y6Q9 20 47501887-47656877 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Acyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "B-cells: 155.8;Plasma cells: 168.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MCF7: 187.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009800, HPA024210" Supported Supported Nucleoplasm,Cytosol NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 16: Immune cells - Immune response" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 57: B-cells - Immune response" Nucleoplasm Cytosol "CAB009800: AB_2251314, HPA024210: AB_10602011" "unprognostic (7.26e-3)" "unprognostic (1.00e-1)" "unprognostic (2.69e-1)" "unprognostic (3.23e-2)" "unprognostic (5.78e-2)" "unprognostic (4.33e-2)" "prognostic unfavorable (8.09e-4)" "unprognostic (2.83e-2)" "unprognostic (1.47e-1)" "unprognostic (5.22e-3)" "unprognostic (2.09e-2)" "unprognostic (2.10e-1)" "unprognostic (2.05e-1)" "unprognostic (1.95e-1)" "unprognostic (2.04e-2)" "unprognostic (4.18e-1)" "unprognostic (1.63e-1)" 14.7 8.2 4.7 22.9 4.7 13.4 11.5 5.7 9.0 11.1 3.8 9.9 8.8 11.8 7.1 14.3 10.7 10.3 13.3 4.0 5.5 9.4 10.5 14.8 35.0 6.5 5.3 14.1 11.1 11.2 6.0 28.1 6.9 9.6 11.2 11.6 11.3 8.8 25.2 14.0 14.8 11.5 5.3 27.5 14.8 7.5 5.9 17.9 12.9 16.5 39.2 15.3 12.5 6.4 17.6 50.1 16.1 21.5 37.5 41.9 105.2 16.4 24.2 27.3 14.1 25.2 19.0 61.8 11.0 28.5 36.1 43.2 12.2 20.7 20.9 31.3 6.4 8.1 15.3 39.3 22.6 6.8 43.3 19.9 61.2 24.4 30.3 23.5 20.0 10.0 18.7 14.0 16.2 187.0 9.9 12.8 5.8 14.2 20.6 17.8 11.0 27.4 16.8 38.2 3.1 5.7 41.0 53.7 18.8 18.0 24.3 17.8 35.8 16.4 12.9 20.5 7.4 38.5 35.9 60.6 19.4 7.0 10.8 2.8 3.9 3.0 2.5 5.2 2.2 9.3 2.3 2.2 5.0 6.8 2.6 2.9 4.5 2.1 5.0 4.2 3.1 2.6 4.7 4.7 5.7 9.0 4.0 5.5 6.5 5.3 6.9 5.3 5.9 6.4 86.7 12.8 23.7 27.7 155.8 34.5 15.7 25.0 52.9 18.1 23.8 13.8 26.1 20.0 29.0 14.7 8.4 69.5 39.9 12.5 5.9 12.9 12.1 36.4 29.1 49.8 14.9 14.9 48.5 19.6 26.2 26.4 26.5 78.8 8.8 15.3 68.2 20.0 22.8 13.5 64.3 10.7 36.7 46.8 62.2 6.0 24.8 58.2 33.8 109.6 46.1 9.3 28.8 49.3 54.1 21.0 16.9 27.4 168.8 28.1 9.0 6.5 39.8 23.8 19.7 19.7 30.3 43.2 30.0 63.3 51.7 89.2 47.6 14.2 11.7 59.2 NCOA6 "AIB3, ASC2, KIAA0181, NRC, PRIP, RAP250, TRBP" ENSG00000198646 "Nuclear receptor coactivator 6" Q14686 20 34689097-34825651 "Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" Activator "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 130.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004198, HPA050211" Supported Supported Nucleoplasm NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA004198: AB_1078228, HPA050211: AB_2681052" "unprognostic (2.48e-1)" "unprognostic (4.81e-2)" "unprognostic (1.72e-1)" "unprognostic (1.37e-2)" "unprognostic (1.23e-1)" "unprognostic (1.10e-1)" "prognostic unfavorable (4.65e-4)" "unprognostic (2.05e-1)" "unprognostic (2.16e-1)" "unprognostic (1.40e-1)" "unprognostic (3.87e-2)" "unprognostic (1.51e-1)" "prognostic favorable (8.78e-5)" "unprognostic (9.04e-2)" "unprognostic (1.59e-1)" "unprognostic (1.12e-1)" "unprognostic (4.42e-2)" 10.2 9.0 5.2 9.1 6.7 14.0 9.2 12.7 12.4 10.8 4.8 12.9 13.2 10.7 12.2 11.7 11.3 8.8 9.2 6.1 8.2 9.9 8.4 10.4 8.9 6.3 4.6 11.6 12.6 22.0 10.0 13.5 4.6 9.8 14.5 26.7 12.9 11.3 12.7 13.5 12.0 13.2 2.3 9.4 11.4 18.8 7.4 18.1 13.8 13.1 10.3 10.4 10.5 9.6 25.2 14.7 32.6 19.7 17.5 19.4 21.3 12.0 15.3 21.1 16.9 37.9 17.2 17.7 12.9 21.5 25.8 30.0 29.3 20.2 23.9 9.0 13.2 41.6 16.7 22.4 19.3 23.5 29.4 14.8 36.5 19.8 24.5 14.6 20.2 20.1 21.5 23.7 17.7 16.3 37.5 14.8 6.7 21.0 21.1 24.9 39.3 15.9 15.6 16.6 27.2 18.5 22.0 52.5 20.5 15.0 22.2 18.5 20.0 34.1 20.7 25.6 20.2 26.9 24.3 20.0 22.5 13.5 15.5 1.1 0.6 2.5 0.9 0.5 0.8 1.0 0.8 0.8 1.1 0.8 0.7 0.5 1.5 0.7 0.7 1.0 0.5 0.5 5.2 6.7 12.7 12.4 6.1 8.2 6.3 4.6 4.6 2.3 7.4 9.6 17.3 25.6 16.0 54.9 11.0 17.0 9.1 10.6 13.6 28.8 14.3 10.9 20.1 18.6 11.6 16.5 29.2 13.0 12.2 31.9 5.9 12.5 23.5 16.4 21.3 14.0 10.8 13.3 50.9 12.4 12.1 14.5 15.8 23.3 6.3 18.5 13.9 12.1 10.8 33.7 58.8 17.4 20.3 12.2 10.3 17.3 18.0 13.0 10.6 45.9 17.6 11.5 13.4 54.3 130.4 15.4 12.4 13.5 14.2 16.9 20.3 9.3 17.5 29.8 26.3 16.6 16.9 25.6 27.1 19.2 20.9 15.9 13.1 13.6 17.6 14.6 NCOR1 "hCIT529I10, hN-CoR, KIAA1047, MGC104216, N-CoR, PPP1R109, TRAC1" ENSG00000141027 "Nuclear receptor corepressor 1" O75376 17 16029157-16218185 "Cancer-related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Biological rhythms, Transcription, Transcription regulation" "Chromatin regulator, DNA-binding, Repressor" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043246, HPA050288, HPA051168, CAB072830" Supported Enhanced Nucleoplasm,Cytosol NA NA "Cluster 6: Non-specific - Transcription" "Cluster 6: Brain - Smell perception" "Cluster 12: NES - Nervous system development" "Cluster 52: Non-specific - Transcription" Nucleoplasm Cytosol "CAB072830: , HPA043246: AB_2678386, HPA050288: AB_2681073, HPA051168: AB_2681370" "unprognostic (1.83e-1)" "unprognostic (3.05e-1)" "unprognostic (9.17e-2)" "unprognostic (1.10e-1)" "unprognostic (7.38e-2)" "unprognostic (3.59e-2)" "unprognostic (2.55e-2)" "unprognostic (4.27e-2)" "unprognostic (4.87e-2)" "unprognostic (4.06e-2)" "unprognostic (7.07e-2)" "unprognostic (1.52e-2)" "prognostic favorable (7.92e-5)" "unprognostic (4.40e-2)" "unprognostic (2.52e-1)" "unprognostic (1.33e-1)" "unprognostic (5.42e-2)" 22.1 18.3 37.8 28.1 39.7 42.8 29.0 60.8 84.7 27.3 41.0 44.0 47.1 30.7 20.3 30.6 25.1 26.4 23.4 39.3 34.7 33.6 46.2 26.9 29.9 32.7 35.7 33.5 34.2 42.3 17.1 28.3 31.0 27.6 40.6 41.4 22.4 31.4 42.0 31.6 38.2 29.7 28.2 29.3 42.7 32.4 35.4 51.9 34.8 39.9 34.7 28.8 18.3 43.4 68.0 110.6 77.7 65.1 62.4 47.1 38.6 48.9 54.8 52.4 47.1 59.8 30.3 70.9 33.6 85.9 39.3 50.4 96.4 59.2 77.3 95.6 71.1 70.7 96.3 71.1 60.8 45.3 80.7 48.5 60.6 81.2 94.4 45.2 73.9 98.0 63.0 28.8 52.3 44.3 79.3 29.1 38.6 118.6 29.9 78.1 78.5 33.5 54.9 76.0 26.5 43.8 80.7 34.7 37.7 197.5 33.5 50.3 65.5 53.7 32.6 39.9 68.3 19.7 25.0 40.4 51.0 52.4 47.0 408.4 104.8 240.4 126.9 86.0 106.7 188.4 144.0 141.0 76.3 191.4 139.8 139.0 205.2 139.9 112.3 130.3 144.7 98.8 37.8 39.7 60.8 84.7 39.3 34.7 32.7 35.7 31.0 28.2 35.4 43.4 90.9 80.1 113.2 116.2 130.0 67.8 106.2 91.3 86.0 150.3 76.8 60.8 91.5 82.9 86.9 53.3 158.4 102.1 121.7 198.1 35.2 95.5 69.7 75.7 109.5 88.4 87.9 132.1 127.0 96.5 101.7 77.1 149.4 103.7 87.3 88.9 67.5 126.4 76.1 129.5 122.2 118.8 81.4 81.9 76.7 43.6 101.5 96.7 37.4 107.7 172.8 83.1 197.8 123.1 151.4 111.7 148.3 121.5 88.5 95.6 194.4 46.7 63.8 167.1 92.1 106.0 106.2 98.7 90.2 78.0 68.2 87.6 142.1 89.5 153.0 122.9 NCOR2 "CTG26, SMRT, SMRTE, TNRC14, TRAC-1" ENSG00000196498 "Nuclear receptor corepressor 2" Q9Y618 12 124324415-124567589 "Cancer-related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "DNA-binding, Repressor" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "basophil: 6.0;non-classical monocyte: 2.5" "Group enriched" "Detected in many" 4 "granulocytes: 6.0;monocytes: 2.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001928 Approved Supported Nucleoplasm NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 72: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 52: Non-specific - Transcription" Nucleoplasm "HPA001928: AB_1079454" "unprognostic (9.51e-3)" "unprognostic (7.37e-3)" "unprognostic (4.66e-2)" "unprognostic (2.55e-3)" "unprognostic (2.14e-1)" "unprognostic (7.37e-2)" "unprognostic (3.19e-2)" "unprognostic (8.86e-2)" "unprognostic (2.21e-2)" "unprognostic (2.90e-3)" "unprognostic (6.42e-3)" "unprognostic (1.96e-1)" "unprognostic (9.86e-2)" "unprognostic (6.26e-2)" "unprognostic (1.59e-1)" "unprognostic (7.56e-2)" "unprognostic (8.90e-2)" 48.1 51.1 41.2 34.3 15.8 29.9 49.7 27.2 45.6 62.9 13.6 56.2 25.2 58.6 9.0 33.3 49.0 21.4 56.7 61.3 12.6 37.6 27.5 62.8 19.5 56.4 29.2 70.8 49.3 18.1 84.1 20.2 53.0 57.7 10.9 20.7 55.1 22.0 109.2 56.2 36.8 22.5 5.4 35.7 45.8 26.1 26.4 19.9 40.5 19.9 11.2 47.4 43.9 27.0 78.6 143.6 40.4 38.7 23.0 31.1 120.4 79.3 39.0 45.2 20.1 76.9 56.3 78.7 57.0 65.1 40.7 72.6 16.2 84.7 18.5 83.6 31.5 63.6 142.1 48.0 46.0 48.3 77.5 50.1 30.9 56.6 33.4 69.2 43.7 35.5 83.3 22.9 41.2 67.4 174.3 55.5 56.4 29.8 139.0 55.8 67.1 40.2 21.6 89.9 106.0 77.1 97.3 81.1 47.7 30.2 66.3 59.8 212.0 104.5 178.9 104.3 170.5 43.5 48.0 48.1 59.4 35.4 100.1 6.0 0.4 1.0 1.0 0.2 0.3 0.3 0.3 0.8 0.2 0.1 0.3 0.2 0.9 0.1 2.5 0.9 0.0 0.3 41.2 15.8 27.2 45.6 61.3 12.6 56.4 29.2 53.0 5.4 26.4 27.0 30.6 115.4 58.9 46.4 14.7 33.3 24.6 22.2 33.0 95.3 33.3 28.3 30.4 18.6 38.8 18.4 39.6 8.8 27.4 39.1 3.9 22.1 2.2 28.0 53.4 28.2 18.7 11.6 61.9 27.2 39.7 50.6 37.8 32.4 42.3 43.5 18.5 19.0 28.4 121.1 37.0 20.3 4.1 50.0 48.7 7.1 62.1 44.8 16.0 51.5 27.0 28.0 20.6 70.9 65.9 38.0 22.2 65.1 22.6 23.7 25.4 8.0 16.8 65.9 6.6 63.0 35.5 1.8 11.6 17.7 24.4 12.6 25.1 69.4 21.9 23.1 NEDD4 "KIAA0093, MGC176705, NEDD4-1, RPF1" ENSG00000069869 "NEDD4 E3 ubiquitin protein ligase" P46934 15 55826922-55993660 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transporters" "Host-virus interaction, Neurogenesis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 67.6;tongue: 58.1" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 93.0;Alveolar cells type 2: 116.7;granulocytes: 73.2;Oligodendrocyte precursor cells: 69.9;Respiratory ciliated cells: 75.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001991, HPA039883, CAB072833" Approved Approved Cytosol NA NA 6500 "Cluster 39: Non-specific - mRNA processing" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 11: Alveolar cells - Smell perception" Cytosol "CAB001991: , CAB072833: , HPA039883: AB_10795683" "unprognostic (1.18e-1)" "unprognostic (2.10e-2)" "unprognostic (5.66e-3)" "unprognostic (1.15e-1)" "unprognostic (6.97e-2)" "unprognostic (2.23e-1)" "unprognostic (3.18e-3)" "prognostic unfavorable (5.14e-4)" "unprognostic (1.36e-2)" "unprognostic (1.62e-1)" "unprognostic (4.96e-2)" "unprognostic (1.43e-2)" "prognostic unfavorable (3.74e-6)" "unprognostic (6.38e-3)" "unprognostic (2.98e-1)" "unprognostic (2.22e-1)" "unprognostic (2.35e-2)" 6.2 3.6 1.7 4.0 2.0 6.2 6.9 1.9 2.0 5.4 1.9 5.7 4.1 7.1 2.9 4.3 3.5 5.6 4.5 1.5 2.7 6.7 27.4 5.3 3.1 2.5 1.9 4.0 1.8 5.4 2.1 15.6 2.6 5.5 4.4 4.5 3.1 7.6 67.6 9.2 8.1 8.0 2.0 4.9 3.4 1.8 2.2 5.6 7.1 58.1 3.0 5.6 4.4 2.6 21.5 32.8 9.0 8.8 11.5 18.5 14.1 40.0 62.9 29.1 28.5 14.5 6.3 4.8 10.4 15.4 70.2 34.6 9.7 26.3 48.2 11.1 5.6 26.1 7.2 7.9 59.0 10.6 2.3 30.8 64.7 35.2 58.9 14.2 24.3 14.9 11.5 0.0 86.4 10.7 15.2 0.1 2.2 10.9 5.1 10.5 67.5 3.1 11.9 42.3 0.7 5.1 17.4 12.5 15.7 15.8 15.2 8.8 84.5 63.9 20.6 13.5 66.0 3.4 8.1 12.3 42.0 24.6 15.7 0.0 0.1 0.0 0.1 0.4 0.3 0.0 0.2 0.1 0.0 0.0 0.2 0.2 0.2 0.1 0.2 0.2 0.1 0.1 1.7 2.0 1.9 2.0 1.5 2.7 2.5 1.9 2.6 2.0 2.2 2.6 35.9 93.0 116.7 28.4 1.6 12.1 3.4 5.5 8.6 0.7 4.6 8.0 5.7 7.2 44.8 0.0 22.9 23.2 2.0 5.2 1.9 3.3 1.7 1.7 13.3 31.1 0.0 17.5 4.2 5.8 7.5 18.5 5.1 1.6 73.2 4.2 17.5 20.5 4.7 0.0 11.9 4.0 2.0 2.2 2.3 1.6 5.6 8.8 1.8 30.0 1.1 8.6 6.2 69.9 28.7 2.9 0.8 7.2 1.9 4.5 25.8 13.4 75.5 6.7 0.0 11.5 17.7 5.3 7.2 7.1 10.4 13.8 9.4 4.8 5.6 1.9 NEDD4L "KIAA0439, NEDD4-2, RSP5" ENSG00000049759 "NEDD4 like E3 ubiquitin protein ligase" Q96PU5 18 58044226-58401540 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Differentiation, Host-virus interaction, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 253.2;Excitatory neurons: 280.9" "Cancer enhanced" "Detected in all" "prostate cancer: 29.1" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 4 "T-reg: 5.1" "Lineage enriched" "Detected in many" 4 "T-cells: 5.1" "Cell line enhanced" "Detected in many" "SK-MEL-30: 146.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024618 Approved "Intracellular and membrane" NA NA "Cluster 35: T-regs - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA024618: AB_1854362" "unprognostic (2.56e-1)" "unprognostic (2.41e-2)" "unprognostic (1.58e-2)" "unprognostic (3.14e-1)" "unprognostic (3.90e-2)" "unprognostic (1.50e-1)" "unprognostic (2.11e-3)" "unprognostic (2.26e-2)" "unprognostic (9.24e-3)" "unprognostic (4.39e-2)" "unprognostic (1.24e-1)" "unprognostic (1.27e-1)" "prognostic favorable (6.55e-15)" "unprognostic (2.42e-1)" "unprognostic (8.26e-2)" "unprognostic (8.49e-3)" "unprognostic (4.75e-2)" 11.2 16.8 20.9 6.7 34.4 27.0 25.8 25.1 31.3 7.6 0.7 38.8 18.7 5.3 10.0 12.0 9.1 9.5 26.9 32.3 16.2 53.4 36.5 47.9 4.1 10.9 18.4 6.4 60.5 13.6 28.4 12.0 10.4 64.2 42.8 20.5 27.5 20.4 34.0 11.2 33.8 6.2 8.6 7.9 51.5 7.8 16.7 4.5 17.4 13.1 7.9 19.4 5.9 16.3 70.7 24.5 14.6 20.9 5.1 2.1 49.8 19.2 88.2 48.6 74.6 28.6 37.1 15.1 57.7 7.4 51.3 50.3 19.5 86.1 100.8 34.9 15.5 10.6 14.3 111.3 2.4 0.5 6.0 13.0 54.6 66.4 78.8 39.1 4.0 13.2 18.7 6.3 20.0 16.2 1.0 1.0 12.2 26.7 33.3 14.3 20.1 17.6 47.0 88.7 17.5 5.0 16.1 5.1 146.1 28.3 29.4 5.6 28.8 131.5 38.5 7.5 83.4 8.3 15.3 9.5 27.6 10.8 10.8 0.7 0.3 1.2 0.2 0.3 0.5 0.8 0.6 0.1 0.1 0.3 0.3 0.2 0.2 0.3 0.1 0.1 5.1 0.3 20.9 34.4 25.1 31.3 32.3 16.2 10.9 18.4 10.4 8.6 16.7 16.3 6.0 253.2 144.8 110.4 5.1 112.8 161.2 34.0 86.6 18.1 99.5 65.9 47.8 64.3 112.8 62.5 173.0 13.0 3.6 144.5 49.0 35.7 22.6 64.0 7.3 14.7 45.2 57.9 280.9 49.2 4.7 9.5 114.7 75.0 3.8 4.7 17.5 41.3 7.3 62.2 173.3 201.5 101.7 8.4 8.2 6.6 3.4 13.3 14.2 88.1 7.3 45.2 2.1 11.1 105.0 49.9 145.3 17.7 12.7 126.9 127.3 91.6 72.7 10.0 0.0 34.3 6.0 1.1 12.5 62.3 53.0 80.0 6.6 8.2 72.9 155.5 NEK1 "KIAA1901, NY-REN-55" ENSG00000137601 "NIMA related kinase 1" Q96PY6 4 169392809-169612627 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Cilium biogenesis/degradation, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Amyotrophic lateral sclerosis, Ciliopathy, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 162.6;Excitatory neurons: 126.3;Inhibitory neurons: 170.5;Oligodendrocytes: 196.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020873, HPA040413" Approved Supported "Nucleoplasm,Centriolar satellite,Cytosol" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 21: Non-specific - Transcription" "Cluster 2: Karpas-707 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "Nucleoplasm, Centriolar satellite" "HPA020873: AB_10671583, HPA040413: AB_10671169" "unprognostic (4.10e-2)" "unprognostic (2.97e-1)" "unprognostic (1.59e-2)" "unprognostic (1.97e-1)" "unprognostic (6.98e-2)" "unprognostic (3.10e-1)" "unprognostic (3.95e-1)" "unprognostic (3.29e-1)" "unprognostic (1.13e-1)" "unprognostic (2.78e-1)" "unprognostic (4.06e-3)" "unprognostic (2.21e-1)" "prognostic favorable (1.42e-4)" "unprognostic (1.07e-1)" "unprognostic (1.03e-1)" "unprognostic (2.10e-2)" "unprognostic (3.46e-1)" 6.0 6.1 5.1 4.9 6.8 4.2 5.2 7.1 5.3 7.6 2.7 4.0 3.2 7.3 2.8 4.6 9.3 6.1 6.9 3.5 8.8 5.9 4.2 4.6 5.3 7.5 7.7 9.4 4.0 6.5 2.9 4.3 7.6 6.7 4.4 8.7 4.2 6.0 3.3 2.3 3.5 6.6 7.6 5.1 4.9 11.8 5.3 6.8 7.9 4.6 4.6 5.6 2.8 7.7 5.8 2.5 10.0 11.0 15.5 17.1 3.3 11.9 10.6 9.3 8.8 3.3 6.7 15.4 2.2 10.4 9.0 1.9 9.7 10.1 10.5 16.9 6.5 10.3 10.4 3.9 9.0 10.6 7.9 13.7 5.9 9.5 16.7 19.1 9.3 14.5 18.6 28.2 12.1 3.7 13.6 4.6 3.3 3.6 6.0 8.4 6.5 4.9 9.7 6.8 11.0 12.5 8.6 4.2 8.1 7.7 5.3 4.6 11.2 6.0 5.4 6.2 8.1 11.3 18.6 11.6 9.7 5.1 10.7 5.1 0.9 0.9 1.9 1.5 2.2 2.0 1.5 1.2 0.7 2.0 2.2 2.3 0.6 1.1 0.7 1.6 1.6 0.7 5.1 6.8 7.1 5.3 3.5 8.8 7.5 7.7 7.6 7.6 5.3 7.7 12.2 12.8 16.4 162.6 34.2 9.6 15.8 12.1 21.1 21.8 11.3 12.7 37.2 4.3 17.8 18.4 29.2 20.8 17.0 6.4 17.6 10.4 109.7 67.2 21.6 13.2 7.2 26.7 126.3 6.2 8.6 25.0 17.3 23.7 18.3 20.1 9.7 7.8 10.7 18.5 170.5 5.6 20.3 7.0 7.4 48.2 23.6 14.5 5.4 53.4 6.6 26.1 15.5 115.1 196.1 8.9 4.0 31.6 23.2 6.9 5.3 9.6 68.4 24.9 13.1 32.8 25.5 67.9 37.3 21.3 6.3 29.6 22.0 26.0 6.3 9.2 NEK11 FLJ23495 ENSG00000114670 "NIMA related kinase 11" Q8NG66 3 131026850-131350465 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 26.2" "Cell type enhanced" "Detected in many" "Astrocytes: 60.7;Early spermatids: 156.4;Endometrial ciliated cells: 69.2;Excitatory neurons: 91.0;Late spermatids: 109.2;Respiratory ciliated cells: 102.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA016908 Approved Supported Nucleoplasm NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 49: Ciliated cells - Cilium organization" Nucleoplasm "HPA016908: AB_1854364" "unprognostic (9.15e-3)" "prognostic favorable (7.10e-4)" "unprognostic (1.05e-1)" "unprognostic (1.08e-1)" "unprognostic (9.96e-2)" "unprognostic (4.85e-3)" "unprognostic (2.48e-5)" "unprognostic (5.38e-2)" "unprognostic (1.86e-1)" "unprognostic (1.18e-1)" "unprognostic (2.27e-1)" "unprognostic (1.79e-1)" "prognostic favorable (5.92e-6)" "unprognostic (2.46e-2)" "unprognostic (1.60e-1)" "unprognostic (2.72e-2)" "unprognostic (1.58e-1)" 3.1 4.3 8.3 0.5 8.3 0.1 6.6 6.9 7.7 5.4 26.2 2.1 1.3 4.9 7.1 2.3 21.4 4.6 2.1 7.3 9.0 6.3 0.6 4.3 1.0 14.2 15.5 6.4 2.2 4.8 5.6 2.2 12.4 2.9 2.4 5.6 2.9 3.7 1.1 2.2 1.8 2.7 12.8 1.2 1.6 15.5 9.3 0.9 9.6 0.8 1.2 2.8 2.5 12.8 5.7 2.2 1.6 4.8 6.2 9.3 0.9 2.7 5.0 4.1 3.1 2.1 7.7 0.2 1.9 4.8 3.9 3.0 0.4 4.6 5.6 0.5 0.6 0.8 0.3 1.0 2.1 0.6 1.3 3.9 7.7 4.2 1.9 4.3 0.8 2.4 0.2 0.8 6.9 3.9 0.1 0.4 0.5 0.9 2.1 0.0 0.1 0.1 9.3 2.2 2.0 2.2 1.3 0.1 1.9 0.7 4.4 0.1 0.9 4.1 2.0 3.3 1.3 1.2 2.2 0.1 2.9 0.2 0.7 0.0 0.0 0.2 0.1 0.3 0.2 0.1 0.6 0.5 0.1 0.1 0.2 0.1 0.1 0.0 0.2 0.2 0.3 0.0 8.3 8.3 6.9 7.7 7.3 9.0 14.2 15.5 12.4 12.8 9.3 12.8 2.5 16.0 3.2 60.7 1.5 4.2 3.4 4.5 4.6 2.6 7.3 7.5 1.6 4.3 18.8 1.8 6.2 1.0 1.4 3.3 5.9 6.4 156.4 69.2 6.1 3.5 2.4 0.4 91.0 2.5 1.1 7.7 2.6 6.6 0.0 8.1 5.7 0.6 2.0 0.0 42.0 3.5 6.1 0.3 1.7 109.2 6.8 2.0 0.0 21.5 0.8 6.4 1.0 38.7 38.9 3.7 3.9 6.0 0.8 1.6 1.7 10.6 102.7 7.3 6.6 7.2 3.7 33.4 5.2 2.6 2.0 1.6 1.4 11.5 2.4 2.7 NEK2 "NEK2A, NLK1, PPP1R111, RP67" ENSG00000117650 "NIMA related kinase 2" P51955 1 211658657-211675630 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Chromosome partition, Meiosis, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "bone marrow: 17.9;lymphoid tissue: 19.2;testis: 67.1" "Group enriched" "Detected in many" 4 "Early spermatids: 76.1;Spermatocytes: 244.2" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Region enhanced" "Detected in many" "cerebellum: 5.7" "Low region specificity" "Detected in all" "CAB017530, HPA064967" Enhanced Supported Nucleoplasm,Centrosome NA Yes "Cluster 41: Basophils - Cellular respiration" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" "Nucleoplasm, Centrosome" "CAB017530: AB_1126558, HPA064967: AB_2685393" "unprognostic (1.28e-1)" "unprognostic (2.33e-1)" "unprognostic (1.02e-1)" "unprognostic (8.51e-2)" "unprognostic (1.83e-1)" "unprognostic (1.35e-2)" "prognostic unfavorable (9.47e-6)" "prognostic unfavorable (9.11e-4)" "unprognostic (1.95e-2)" "unprognostic (2.00e-2)" "unprognostic (1.09e-3)" "unprognostic (8.49e-2)" "unprognostic (0.00e+0)" "unprognostic (8.21e-2)" "unprognostic (4.11e-2)" "unprognostic (1.25e-2)" "unprognostic (2.71e-1)" 0.7 0.4 0.5 5.3 0.4 17.9 1.5 0.9 0.6 1.1 0.6 5.9 7.4 1.3 0.5 4.4 2.2 0.8 0.4 0.5 0.3 0.3 0.7 0.7 9.0 0.4 0.2 0.4 0.1 0.1 0.0 3.2 0.3 2.5 7.6 1.5 0.8 0.2 0.4 4.3 6.9 2.0 0.2 1.7 2.7 67.1 0.6 19.2 0.4 0.2 10.6 1.3 1.6 0.9 86.0 60.5 45.3 32.6 2.6 4.5 49.7 32.4 30.1 55.4 47.5 32.3 81.7 45.1 15.2 25.2 35.1 44.5 39.9 24.2 69.6 69.5 33.2 21.6 51.4 44.2 0.4 43.2 28.3 1.4 2.9 42.9 45.9 13.4 36.3 45.2 59.9 76.9 56.0 23.6 47.3 28.8 43.0 55.0 30.5 46.2 69.2 68.7 19.7 24.2 41.0 45.0 46.6 51.5 39.3 38.4 79.4 25.1 19.0 27.6 54.1 54.8 88.3 31.6 62.6 59.6 24.1 32.6 46.8 1.2 0.1 0.1 0.1 0.1 0.0 0.5 0.1 0.1 0.0 0.4 0.3 0.2 0.7 1.5 0.1 0.2 1.6 0.3 0.5 0.4 0.9 0.6 0.5 0.3 0.4 0.2 0.3 0.2 0.6 0.9 0.1 0.0 0.5 0.3 1.7 2.9 0.7 3.8 0.6 11.3 1.9 2.2 0.5 0.0 2.9 0.0 0.0 9.4 0.8 1.9 0.0 0.2 76.1 15.2 0.7 0.8 0.0 39.6 0.8 0.2 14.1 1.4 5.6 1.5 0.0 3.6 3.6 0.7 5.8 3.3 0.0 3.2 10.2 2.5 1.1 39.0 2.5 2.1 0.0 0.0 0.0 1.6 2.1 0.0 0.1 0.0 2.5 0.7 5.4 0.7 2.1 0.1 5.2 1.8 6.6 0.0 1.5 244.2 26.1 8.6 1.7 1.4 2.0 0.9 9.5 1.4 NEK3 "HSPK36, MGC29949" ENSG00000136098 "NIMA related kinase 3" P51956 13 52132639-52159861 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Oligodendrocytes: 87.0;Spermatocytes: 49.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019062, HPA043230" Enhanced Approved Microtubules NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 5: NTERA-2 - Transcription" "Cluster 66: Spermatocytes - Spermatogenesis" Microtubules "HPA019062: AB_2670037, HPA043230: AB_2678374" "unprognostic (8.97e-2)" "unprognostic (2.54e-2)" "unprognostic (8.12e-2)" "unprognostic (1.84e-1)" "unprognostic (2.01e-2)" "unprognostic (2.05e-1)" "unprognostic (2.71e-1)" "unprognostic (2.31e-1)" "unprognostic (1.31e-1)" "unprognostic (4.30e-3)" "unprognostic (1.16e-3)" "unprognostic (1.70e-2)" "unprognostic (1.17e-3)" "unprognostic (1.22e-2)" "unprognostic (4.66e-2)" "unprognostic (4.15e-2)" "unprognostic (5.34e-2)" 12.4 3.8 13.7 6.2 18.5 8.6 10.6 12.5 21.8 10.8 11.2 16.2 9.3 9.9 6.9 4.2 8.7 7.4 7.8 12.9 14.2 10.1 7.3 9.0 5.0 18.2 17.8 8.2 8.3 3.8 5.2 17.4 17.3 8.2 16.8 4.7 7.0 5.0 6.0 7.2 12.7 8.6 12.9 8.0 6.7 18.1 19.9 3.2 6.3 3.3 5.4 8.3 7.4 26.3 0.3 2.7 20.2 11.4 6.2 10.8 0.3 6.5 6.2 7.6 8.3 8.6 11.1 0.0 0.4 8.4 6.3 1.5 0.4 4.8 4.8 15.1 11.8 1.9 2.7 23.0 7.6 19.4 10.9 7.2 9.5 4.2 17.6 5.6 13.5 1.0 3.1 7.1 9.0 5.1 1.1 23.4 19.7 4.4 0.5 0.5 1.7 7.6 11.4 1.9 2.2 14.0 2.9 6.4 12.8 19.6 2.5 26.3 12.2 1.0 5.9 6.0 6.7 7.5 2.5 13.1 1.8 6.8 10.8 7.1 6.3 5.1 1.6 5.8 1.0 3.6 1.9 1.0 6.7 1.9 1.4 0.4 0.4 1.6 1.2 5.8 2.9 1.4 13.7 18.5 12.5 21.8 12.9 14.2 18.2 17.8 17.3 12.9 19.9 26.3 28.8 6.4 6.5 9.1 5.9 2.8 4.4 2.8 5.7 3.9 5.5 6.7 7.7 5.7 5.8 7.3 0.0 13.0 8.3 20.1 13.7 7.9 11.5 9.8 14.0 22.7 6.0 3.4 0.6 17.3 14.4 8.7 10.2 11.0 10.1 11.6 18.2 7.4 19.1 3.3 3.4 13.7 6.1 12.4 8.1 4.6 7.2 10.4 12.4 18.7 25.4 3.0 7.2 9.0 87.0 15.6 17.9 6.8 6.0 3.3 22.4 6.8 7.1 5.8 0.0 7.1 9.0 49.7 25.5 3.5 3.4 4.8 4.0 3.9 20.1 5.2 NEK4 "NRK2, pp12301, STK2" ENSG00000114904 "NIMA related kinase 4" P51957 3 52708444-52770946 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 46.0" "Cell type enhanced" "Detected in all" "Spermatocytes: 75.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015750, HPA058543" Enhanced Supported Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 1: Thyroid gland - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" Cytosol "HPA015750: AB_1854367, HPA058543: AB_2732623" "unprognostic (1.32e-1)" "unprognostic (1.57e-1)" "prognostic favorable (2.69e-5)" "unprognostic (9.65e-3)" "unprognostic (3.42e-1)" "unprognostic (6.64e-2)" "unprognostic (8.75e-3)" "unprognostic (2.27e-1)" "unprognostic (7.85e-2)" "unprognostic (5.52e-2)" "unprognostic (1.46e-1)" "unprognostic (1.32e-1)" "unprognostic (3.74e-3)" "unprognostic (5.11e-2)" "unprognostic (2.85e-1)" "unprognostic (1.51e-2)" "unprognostic (8.39e-2)" 6.3 8.2 6.1 7.4 6.7 7.0 9.4 9.1 7.4 8.5 8.6 7.3 6.5 8.7 8.9 6.7 13.6 6.2 6.1 5.9 7.8 9.7 10.8 6.7 8.3 6.8 8.9 13.3 8.1 11.5 7.3 7.6 6.3 7.7 8.2 16.9 7.3 9.0 8.0 3.5 5.6 8.1 6.9 7.2 9.6 46.0 7.8 9.5 13.5 6.1 9.4 7.9 4.9 5.9 19.9 15.2 20.5 16.2 18.2 13.1 22.1 13.9 18.6 25.3 25.4 13.5 14.4 20.4 6.4 13.6 27.9 9.2 25.2 16.3 33.8 20.4 10.6 16.0 18.4 17.3 11.4 39.4 15.4 8.1 14.8 32.5 21.5 13.5 9.6 17.4 20.2 16.1 16.1 17.1 21.4 14.4 17.7 20.9 14.9 18.5 17.8 15.1 14.3 28.3 15.0 9.0 29.1 17.7 14.1 15.7 16.5 23.4 8.9 16.9 17.1 27.3 26.0 17.8 27.9 19.7 19.3 18.2 18.7 13.6 9.8 5.0 3.5 6.1 3.7 2.8 3.0 3.6 5.2 3.5 3.6 3.1 1.4 4.0 4.2 2.6 2.6 5.2 6.1 6.7 9.1 7.4 5.9 7.8 6.8 8.9 6.3 6.9 7.8 5.9 6.2 12.8 8.2 19.2 11.8 4.1 5.3 3.4 4.6 14.1 10.6 6.2 4.6 2.8 11.6 5.5 12.5 7.0 4.8 6.5 9.8 7.0 20.7 24.0 10.6 7.3 4.8 13.3 30.5 9.6 8.1 7.8 12.8 9.9 7.6 14.0 6.8 14.5 8.2 6.7 29.4 9.3 6.1 16.8 4.6 19.5 14.6 10.4 1.8 7.5 14.0 19.4 10.3 16.6 19.3 8.5 2.9 12.4 10.6 5.3 5.4 17.1 22.4 18.9 6.6 12.6 7.3 75.9 27.9 6.9 4.1 6.7 5.8 11.8 9.1 5.2 NEK5 ENSG00000197168 "NIMA related kinase 5" Q6P3R8 13 52033611-52129092 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 5.1;choroid plexus: 7.4;fallopian tube: 8.8;testis: 10.8" "Group enriched" "Detected in many" 4 "Early spermatids: 57.9;Endometrial ciliated cells: 75.8;Late spermatids: 32.0;Respiratory ciliated cells: 98.6;Spermatocytes: 32.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "JURKAT: 1.2;OE19: 2.4;T-47d: 1.1" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA035565, HPA041399" Enhanced NA NA "Cluster 11: Basophils - Unknown function" "Cluster 49: Ciliated cells - Cilium organization" "Cluster 21: OE19 - Mitochondria" "Cluster 49: Ciliated cells - Cilium organization" "HPA035565: AB_10672095, HPA041399: AB_2677453" "unprognostic (4.14e-2)" "unprognostic (1.49e-1)" "unprognostic (1.89e-1)" "unprognostic (5.80e-3)" "unprognostic (2.80e-2)" "unprognostic (2.47e-1)" "unprognostic (3.57e-2)" "unprognostic (6.50e-2)" "unprognostic (8.82e-2)" "unprognostic (1.32e-1)" "unprognostic (1.37e-2)" "unprognostic (2.94e-1)" "unprognostic (2.06e-3)" "unprognostic (1.83e-3)" "unprognostic (1.10e-1)" "unprognostic (1.19e-3)" "unprognostic (9.44e-3)" 0.1 0.1 1.1 0.2 1.5 0.3 0.4 0.7 0.7 0.3 7.4 0.1 0.1 0.5 0.3 0.0 8.8 0.1 0.4 1.5 1.7 0.4 0.0 1.3 0.1 5.1 5.1 0.1 0.1 0.7 0.1 0.4 2.5 0.5 0.2 1.6 0.1 0.1 0.3 0.2 0.1 0.2 3.6 0.2 0.1 10.8 2.6 0.3 0.3 0.1 0.1 0.1 0.0 2.7 0.1 0.1 0.1 0.6 0.0 0.2 0.8 0.0 0.0 0.0 0.1 0.0 0.4 0.2 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.4 0.1 0.1 0.4 0.6 0.1 0.2 0.0 0.1 0.1 0.0 1.2 0.4 0.2 0.0 0.5 0.1 0.3 0.2 2.4 0.2 0.0 0.0 0.0 0.6 0.1 0.1 0.3 0.2 0.0 0.2 0.3 1.1 0.4 0.2 0.0 0.1 0.1 0.1 0.0 0.0 0.1 0.0 0.1 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 1.1 1.5 0.7 0.7 1.5 1.7 5.1 5.1 2.5 3.6 2.6 2.7 1.4 0.0 2.0 2.6 1.5 0.0 1.9 0.3 0.0 9.2 3.0 1.8 2.0 2.8 12.1 7.3 14.6 2.6 2.5 0.5 1.9 1.3 57.9 75.8 1.9 3.0 1.8 0.8 3.8 2.9 2.4 1.6 0.0 2.8 2.5 1.2 0.4 1.2 1.2 13.5 3.1 0.4 2.0 0.3 0.4 32.0 2.1 0.6 0.0 4.7 1.4 2.1 3.1 1.0 6.6 0.8 0.7 2.2 0.5 3.7 1.3 1.5 98.6 13.2 6.6 4.6 1.3 32.2 12.9 0.3 0.1 1.9 1.0 1.2 1.1 1.3 NEK6 SID6-1512 ENSG00000119408 "NIMA related kinase 6" Q9HC98 9 124257606-124353307 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transporters" "Apoptosis, Cell cycle, Cell division, Chromosome partition, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 121.0;Hofbauer cells: 112.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HMC-1: 250.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB045993, HPA056828" Approved Supported "Nucleoplasm,Centriolar satellite,Cytosol" NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 15: Liver - Metabolism" "Cluster 3: HMC-1 - Innate immune response" "Cluster 38: Extravillous trophoblasts - Unknown function" "Nucleoplasm, Cytosol" "Centriolar satellite" "CAB045993: AB_2150651, HPA056828: AB_2683250" "unprognostic (6.27e-2)" "unprognostic (1.02e-2)" "unprognostic (4.15e-2)" "unprognostic (1.65e-2)" "unprognostic (5.22e-2)" "unprognostic (2.47e-2)" "unprognostic (3.13e-3)" "unprognostic (2.13e-2)" "unprognostic (2.38e-1)" "unprognostic (3.30e-2)" "unprognostic (1.38e-3)" "unprognostic (6.53e-2)" "unprognostic (5.03e-3)" "unprognostic (1.97e-1)" "prognostic unfavorable (7.66e-4)" "unprognostic (5.27e-2)" "unprognostic (4.77e-3)" 18.0 6.1 33.5 32.6 34.3 19.6 14.7 28.1 32.4 26.1 26.5 22.3 17.5 12.2 3.4 8.5 11.2 25.4 7.4 31.8 37.0 17.2 68.2 24.3 27.4 49.8 41.2 9.0 16.7 1.9 6.1 30.2 33.9 19.6 22.5 11.3 20.6 16.7 8.2 5.4 25.8 18.7 34.4 16.6 27.1 7.8 44.2 10.2 7.3 3.1 31.7 24.3 6.4 30.4 31.8 50.0 47.8 18.8 88.3 113.9 59.3 38.8 61.1 58.4 48.4 47.7 57.0 38.2 61.0 74.6 133.2 5.9 24.7 111.7 39.4 43.7 21.8 104.4 42.1 85.4 105.2 19.4 250.0 152.8 17.8 55.4 56.9 152.3 64.3 17.6 19.5 1.7 105.6 32.6 0.9 20.8 12.2 163.7 45.5 40.6 35.6 19.6 62.6 11.4 21.4 7.5 12.6 23.6 54.5 48.3 51.4 76.4 127.5 42.2 42.8 29.5 26.7 8.4 11.4 21.6 53.5 42.3 57.5 28.1 47.6 76.4 9.2 32.1 5.9 52.5 5.5 7.8 29.0 30.2 0.9 3.8 58.8 23.3 41.4 26.9 7.6 21.6 33.5 34.3 28.1 32.4 31.8 37.0 49.8 41.2 33.9 34.4 44.2 30.4 8.4 9.6 4.7 37.9 24.5 2.4 13.8 18.9 4.6 1.0 9.4 6.5 3.3 18.6 8.8 3.7 0.0 47.1 11.3 8.5 1.9 41.3 18.2 9.4 17.7 8.4 6.0 4.0 8.3 23.3 121.0 11.1 19.4 22.2 22.2 1.1 5.0 43.5 112.0 0.0 5.3 18.2 18.3 10.4 22.5 20.0 5.0 31.2 7.2 12.2 57.7 34.6 8.2 15.1 2.4 30.6 11.9 3.8 5.5 17.1 17.2 38.0 3.3 2.1 0.0 4.9 6.4 1.3 17.1 2.4 1.1 36.1 4.5 2.1 18.7 10.2 NEK7 ENSG00000151414 "NIMA related kinase 7" Q8TDX7 1 198156994-198322420 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transporters" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 140.4" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 172.6;Oligodendrocyte precursor cells: 131.2;Oligodendrocytes: 153.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "BJ: 554.5;fHDF/TERT166: 753.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015520, HPA018193" Approved Supported Nucleoplasm Yes No "Cluster 16: MAIT-cells - Unknown function" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm "HPA015520: AB_1854371, HPA018193: AB_1854372" "unprognostic (2.08e-1)" "unprognostic (2.98e-2)" "unprognostic (1.65e-1)" "unprognostic (5.38e-2)" "unprognostic (4.26e-2)" "unprognostic (3.00e-2)" "unprognostic (2.14e-2)" "unprognostic (5.47e-2)" "unprognostic (4.77e-2)" "unprognostic (3.21e-1)" "unprognostic (1.46e-3)" "unprognostic (2.82e-1)" "unprognostic (1.13e-2)" "unprognostic (1.26e-2)" "unprognostic (1.74e-1)" "unprognostic (2.05e-2)" "unprognostic (1.56e-1)" 63.8 49.9 48.3 29.3 58.7 11.1 27.7 45.9 53.3 26.1 35.7 30.0 21.1 26.6 19.7 31.2 22.3 27.2 140.4 39.5 56.1 29.3 30.0 41.6 30.8 61.1 51.3 29.6 20.3 25.1 12.3 42.1 60.0 27.1 23.3 19.6 22.3 36.5 56.6 14.9 25.3 32.2 59.7 32.1 20.1 13.7 49.1 27.7 26.8 63.7 23.6 30.9 20.1 64.2 47.8 12.3 14.8 6.0 37.5 42.6 17.4 554.5 227.6 218.7 102.9 23.0 46.2 17.1 39.4 753.3 12.6 29.0 22.7 30.3 220.8 56.0 32.7 23.6 48.7 9.6 45.3 40.2 46.3 26.7 25.3 144.8 43.5 82.2 42.4 140.0 18.8 41.2 102.3 15.1 34.7 23.4 8.4 37.5 9.9 18.5 36.5 30.7 37.3 24.5 9.5 17.0 92.1 53.0 63.5 20.6 38.8 36.0 95.7 61.8 52.0 178.6 58.9 29.3 28.5 11.8 26.9 36.3 48.7 1.8 2.2 3.3 2.9 1.8 12.8 1.4 3.2 4.1 2.0 1.9 2.7 3.1 6.0 3.6 1.6 1.3 6.0 1.4 48.3 58.7 45.9 53.3 39.5 56.1 61.1 51.3 60.0 59.7 49.1 64.2 34.3 28.9 30.7 78.0 32.4 51.4 15.0 10.2 33.6 8.2 22.8 18.2 172.6 10.0 18.7 18.4 14.6 15.0 32.9 25.8 11.7 10.6 2.8 21.6 20.9 29.3 19.8 32.6 17.0 19.6 15.9 30.0 18.8 19.6 8.8 11.8 40.4 23.5 17.5 3.3 34.6 19.5 8.2 49.5 51.6 3.3 29.2 35.5 30.2 124.6 29.0 11.4 15.5 131.2 153.5 50.1 19.3 38.4 28.5 30.6 25.1 16.6 27.9 24.2 19.7 28.1 35.9 7.7 6.0 29.2 49.2 64.3 41.6 28.7 15.6 33.1 NEK8 NPHP9 ENSG00000160602 "NIMA related kinase 8" Q86SG6 17 28725897-28743455 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Ciliopathy, Disease variant, Nephronophthisis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "plasmacytoid DC: 14.8" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA040661, HPA040679" Approved Approved "Nuclear speckles,Microtubules,Mitotic spindle" Yes NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 7: Kidney - Transmembrane transport" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Microtubules "Nuclear speckles, Mitotic spindle" "HPA040661: AB_10794065, HPA040679: AB_10796226" "unprognostic (2.63e-1)" "unprognostic (4.57e-2)" "prognostic unfavorable (6.98e-4)" "unprognostic (6.25e-2)" "unprognostic (2.23e-2)" "unprognostic (5.93e-3)" "unprognostic (6.48e-2)" "prognostic favorable (4.52e-4)" "unprognostic (7.85e-2)" "unprognostic (1.37e-1)" "unprognostic (1.51e-3)" "unprognostic (1.55e-1)" "unprognostic (4.87e-3)" "unprognostic (4.61e-2)" "unprognostic (3.58e-1)" "unprognostic (1.75e-1)" "unprognostic (4.67e-3)" 1.5 3.1 1.7 3.3 1.9 1.7 2.4 1.4 1.9 2.5 3.8 2.4 3.0 1.5 3.2 2.5 3.9 2.0 1.0 1.4 1.6 9.1 5.2 3.3 5.8 2.0 1.7 1.9 4.5 2.9 4.4 2.6 1.7 4.0 2.2 0.6 3.7 2.6 0.5 3.1 4.2 1.2 1.6 5.8 3.4 3.8 1.9 2.7 7.2 0.4 5.0 2.6 2.2 2.3 2.1 3.4 3.5 2.8 1.9 2.1 10.9 0.9 2.1 1.3 1.7 5.4 5.0 13.1 3.5 2.8 2.5 3.8 5.2 4.8 1.3 3.5 6.4 2.9 5.8 10.1 3.3 1.8 3.7 4.8 1.8 2.5 5.8 1.8 0.9 1.9 4.3 1.3 1.5 4.7 1.9 3.4 3.3 3.7 1.0 4.9 2.3 5.9 7.0 5.7 6.4 1.5 3.0 6.3 1.6 4.7 9.3 2.4 0.8 1.3 2.2 1.6 1.0 1.5 1.8 8.9 2.0 1.6 3.1 3.3 0.9 1.2 0.7 0.5 0.8 2.8 0.6 0.7 0.1 4.2 0.7 1.0 0.4 1.3 1.1 14.8 0.5 0.8 1.7 1.9 1.4 1.9 1.4 1.6 2.0 1.7 1.7 1.6 1.9 2.3 2.7 9.6 19.3 3.9 22.9 2.8 9.2 8.3 7.4 2.8 10.1 14.1 1.7 12.8 11.6 25.8 8.4 17.6 19.1 14.9 7.9 5.8 9.5 12.8 6.0 2.9 10.3 7.0 0.7 6.0 9.2 3.9 6.1 15.2 26.6 3.2 3.3 9.4 3.9 1.7 0.5 14.4 10.2 5.0 2.7 2.0 3.4 4.4 3.6 2.8 4.0 2.6 3.1 1.5 1.6 3.9 17.2 2.6 7.2 8.6 13.4 4.3 14.3 1.8 0.0 11.7 3.0 19.9 11.4 8.8 1.6 11.1 4.9 7.8 15.9 4.2 NEK9 "DKFZp434D0935, MGC16714, Nek8, NERCC, NERCC1" ENSG00000119638 "NIMA related kinase 9" Q8TD19 14 75079353-75127344 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001405 Approved NA NA "Cluster 44: Non-specific - Transcription" "Cluster 52: Non-specific - Ribosome" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 59: Non-specific - Transcription" "HPA001405: AB_1079467" "unprognostic (1.00e-1)" "unprognostic (5.37e-2)" "unprognostic (9.97e-3)" "unprognostic (2.64e-2)" "unprognostic (3.86e-1)" "unprognostic (2.77e-1)" "unprognostic (1.12e-1)" "unprognostic (5.60e-3)" "unprognostic (2.81e-1)" "unprognostic (1.15e-1)" "prognostic favorable (5.63e-4)" "unprognostic (8.58e-2)" "unprognostic (1.36e-2)" "unprognostic (4.54e-2)" "unprognostic (9.22e-2)" "unprognostic (2.61e-1)" "unprognostic (1.57e-2)" 24.2 18.5 6.7 18.6 8.4 11.8 17.3 7.5 7.9 24.3 9.0 14.3 15.5 26.0 10.5 17.8 25.2 17.9 37.2 6.1 7.8 18.4 21.0 18.8 21.0 8.2 7.7 35.8 16.0 34.2 3.1 21.2 7.9 23.5 16.3 16.5 12.4 28.1 43.6 8.1 16.9 32.2 7.5 19.7 13.1 20.4 7.7 28.3 19.7 36.9 23.5 16.3 2.9 9.1 21.3 30.8 44.8 45.4 86.3 88.8 37.9 32.4 54.6 29.7 29.4 25.5 24.7 52.7 0.1 54.2 23.1 31.8 45.0 27.0 38.5 38.2 16.8 23.0 27.3 17.3 48.6 10.8 26.8 76.6 32.8 31.8 26.7 71.6 46.1 36.2 23.8 31.4 40.2 4.8 35.5 11.5 21.9 43.3 18.8 53.5 49.4 23.9 21.3 28.2 19.5 41.3 39.5 19.3 30.0 50.4 41.7 37.6 46.3 30.2 12.7 31.5 15.8 34.3 36.5 49.6 24.9 24.8 26.4 3.4 3.5 3.1 2.5 3.4 4.0 1.3 2.4 2.3 5.0 1.9 3.1 2.8 1.2 3.3 2.5 1.1 1.5 2.9 6.7 8.4 7.5 7.9 6.1 7.8 8.2 7.7 7.9 7.5 7.7 9.1 15.3 12.8 30.2 49.3 21.2 8.8 7.7 6.6 21.1 16.8 14.5 12.4 55.7 12.8 14.8 11.0 35.5 17.4 11.1 10.2 7.9 6.9 11.9 13.3 23.1 17.6 5.4 16.2 31.3 4.9 16.2 18.1 10.7 10.4 16.4 36.8 17.9 30.3 13.9 13.5 35.9 10.7 6.1 18.6 11.8 8.3 24.8 17.0 3.6 30.9 16.0 12.0 15.5 41.2 59.5 5.3 11.7 26.4 14.7 7.4 13.1 8.4 17.4 23.1 0.0 18.9 16.7 28.8 13.9 17.4 10.2 14.0 16.5 20.8 10.5 5.6 NEURL1 "h-neu, neu-1, NEURL, RNF67" ENSG00000107954 "Neuralized E3 ubiquitin protein ligase 1" O76050 10 103493979-103592552 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Notch signaling pathway, Translation regulation, Ubl conjugation pathway" Transferase "Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 146.9;tongue: 60.5" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 93.8;Early spermatids: 128.7;Intestinal goblet cells: 105.4;Late spermatids: 461.2;Paneth cells: 183.4;Syncytiotrophoblasts: 113.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Group enriched" "Detected in many" 13 "intermediate monocyte: 45.1;non-classical monocyte: 112.0" "Lineage enriched" "Detected in many" 19 "monocytes: 112.0" "Cell line enhanced" "Detected in some" "BEWO: 13.7;HeLa: 8.6;HMC-1: 6.9;JURKAT: 7.4;SCLC-21H: 17.1;SiHa: 8.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044204 Enhanced NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 80: Striated muscle - Unknown function" "Cluster 28: BEWO - Transcription regulation" "Cluster 25: Spermatids - Spermatogenesis" "HPA044204: AB_10959383" "unprognostic (1.21e-2)" "unprognostic (8.14e-2)" "unprognostic (1.18e-3)" "unprognostic (1.58e-4)" "unprognostic (1.31e-2)" "unprognostic (2.60e-1)" "unprognostic (5.24e-2)" "unprognostic (2.54e-1)" "unprognostic (1.37e-1)" "unprognostic (4.31e-2)" "unprognostic (1.32e-3)" "unprognostic (1.08e-1)" "unprognostic (8.61e-3)" "unprognostic (1.59e-1)" "unprognostic (1.44e-1)" "unprognostic (2.91e-4)" "unprognostic (3.23e-1)" 0.5 4.6 25.5 3.8 29.6 2.2 0.4 20.8 37.4 14.1 0.0 15.2 10.9 25.8 15.1 4.3 2.6 1.9 0.5 32.2 7.2 2.4 1.2 0.9 0.8 1.7 4.1 1.9 18.8 8.3 15.9 4.6 1.3 1.4 10.3 39.5 2.9 1.3 146.9 1.8 17.2 5.2 0.0 1.9 5.2 13.0 5.0 1.1 0.5 60.5 0.5 18.7 2.6 17.2 0.9 0.2 1.3 0.0 0.2 0.1 13.7 0.5 0.9 0.2 0.1 0.3 0.2 0.4 0.7 0.1 0.9 0.6 0.4 0.2 0.1 0.4 0.8 0.2 8.6 0.3 0.0 0.3 6.9 0.2 0.5 0.1 0.7 0.2 0.0 7.4 2.3 0.5 0.2 1.2 1.4 0.9 0.0 0.5 4.2 0.2 0.7 1.5 0.0 0.5 17.1 5.9 8.8 0.0 0.4 2.5 0.7 1.7 0.0 0.1 0.9 0.3 0.2 1.0 0.2 0.3 0.5 0.0 0.4 0.8 2.8 0.5 0.7 45.1 1.1 1.1 1.0 1.1 5.8 0.7 1.2 0.8 2.3 0.6 112.0 4.7 0.4 4.1 25.5 29.6 20.8 37.4 32.2 7.2 1.7 4.1 1.3 0.0 5.0 17.2 0.3 0.0 0.6 1.3 1.5 0.5 1.5 0.2 0.0 53.2 2.0 2.7 1.6 0.0 0.2 0.0 93.8 4.6 3.1 7.9 0.0 12.0 128.7 0.0 0.8 2.2 78.3 4.6 47.9 0.7 12.9 2.2 13.3 0.1 0.0 1.2 0.0 0.2 4.5 3.3 32.9 105.4 32.6 4.6 2.4 461.2 5.6 4.8 0.0 0.0 5.5 9.0 2.1 1.0 4.2 0.5 183.4 5.3 0.6 1.3 7.2 0.0 0.2 88.0 6.6 2.4 1.0 56.6 33.6 0.0 1.8 113.4 1.7 8.4 9.4 0.7 NEURL1B "DKFZP761M1511, Neur2, RNF67B" ENSG00000214357 "Neuralized E3 ubiquitin protein ligase 1B" A8MQ27 5 172641263-172691540 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Notch signaling pathway, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Adipocytes: 82.8;Distal enterocytes: 82.5;Endothelial cells: 53.8;Leydig cells: 54.7;Paneth cells: 42.1;Proximal enterocytes: 53.4;Smooth muscle cells: 58.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "REH: 43.7;T-47d: 20.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA037612 Approved Supported "Actin filaments,Cytosol" NA Yes "Cluster 46: Fibroblasts - ECM organization" "Cluster 14: REH - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "Actin filaments" "HPA037612: AB_10795573" "unprognostic (3.56e-2)" "unprognostic (8.46e-2)" "unprognostic (6.72e-3)" "unprognostic (2.70e-1)" "unprognostic (1.64e-1)" "unprognostic (1.55e-1)" "unprognostic (6.58e-2)" "unprognostic (2.95e-1)" "unprognostic (2.86e-1)" "unprognostic (1.09e-1)" "unprognostic (7.13e-3)" "unprognostic (6.81e-2)" "prognostic unfavorable (3.00e-6)" "unprognostic (1.79e-1)" "unprognostic (1.40e-1)" "unprognostic (4.67e-2)" "unprognostic (3.22e-3)" 25.0 16.0 8.4 5.2 10.3 2.0 21.1 2.3 24.1 18.3 3.4 28.4 6.9 24.7 24.1 13.5 22.0 11.7 32.2 17.1 6.9 11.0 6.0 12.6 3.7 3.5 4.6 14.7 5.3 3.2 8.2 6.1 3.8 17.6 13.7 0.3 6.6 32.1 14.0 18.1 17.6 20.4 3.6 0.7 7.7 4.3 6.3 5.9 10.3 16.0 3.9 25.7 17.3 6.5 7.2 3.7 2.0 8.9 0.6 0.3 0.1 8.0 3.5 4.1 6.0 13.7 3.2 0.0 2.1 5.2 5.0 2.1 0.7 3.6 2.8 13.2 0.5 9.8 13.3 0.1 0.6 0.0 2.9 0.0 15.1 0.9 4.1 1.2 0.6 1.4 0.0 3.0 8.9 8.0 2.3 0.2 1.3 3.1 0.3 43.7 9.4 1.4 0.1 1.6 1.6 8.9 7.6 11.9 0.3 3.5 20.0 1.5 1.3 3.1 18.1 2.2 5.1 1.2 0.4 0.0 9.0 0.2 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.4 10.3 2.3 24.1 17.1 6.9 3.5 4.6 3.8 3.6 6.3 6.5 82.8 0.0 1.9 0.3 0.6 4.8 0.7 3.0 0.6 0.6 1.5 1.3 9.3 1.5 4.8 0.0 0.0 0.3 0.4 82.5 0.0 0.7 2.6 1.9 2.5 53.8 13.9 11.4 5.2 0.7 0.2 10.3 2.0 0.6 0.0 4.9 30.4 0.3 0.3 0.0 1.0 10.2 2.0 1.9 2.6 6.6 54.7 2.2 7.2 4.7 0.7 0.7 0.0 5.0 13.0 4.5 42.1 12.4 0.1 1.9 53.4 0.8 12.8 0.3 26.3 11.6 58.8 2.5 3.4 7.7 5.4 0.1 0.7 2.5 20.0 1.2 NGLY1 "FLJ11005, PNG-1, PNG1" ENSG00000151092 "N-glycanase 1" Q96IV0 3 25718944-25790039 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 7 "Early spermatids: 594.1;Late spermatids: 963.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036825 Approved "Intracellular and membrane" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 25: Spermatids - Spermatogenesis" "HPA036825: AB_10672231" "unprognostic (3.65e-2)" "unprognostic (8.65e-2)" "prognostic favorable (1.17e-5)" "unprognostic (2.96e-2)" "unprognostic (1.72e-2)" "unprognostic (1.59e-2)" "prognostic unfavorable (1.96e-6)" "unprognostic (2.20e-1)" "unprognostic (2.34e-1)" "unprognostic (3.73e-3)" "unprognostic (2.55e-1)" "unprognostic (4.23e-2)" "unprognostic (4.92e-3)" "unprognostic (1.07e-2)" "unprognostic (2.47e-1)" "unprognostic (9.08e-2)" "unprognostic (1.89e-2)" 10.8 13.7 6.9 15.1 7.1 25.6 15.6 10.0 9.2 12.3 10.5 17.9 14.6 9.7 16.2 12.3 11.5 9.8 16.1 7.5 8.0 17.8 22.4 11.4 25.9 8.1 9.2 11.8 15.9 11.6 5.9 11.9 8.2 14.2 20.6 13.5 14.9 9.9 49.5 9.8 15.4 12.1 6.7 15.5 15.3 55.8 9.1 27.4 13.6 38.1 25.3 16.1 9.9 8.6 27.6 24.2 12.8 27.4 23.5 22.7 15.0 21.6 20.4 29.7 25.5 14.8 20.9 64.3 24.5 19.9 28.3 12.1 45.5 14.0 39.2 27.8 18.5 49.9 15.1 24.8 29.0 48.3 25.7 20.3 17.5 33.6 31.5 32.2 31.3 32.8 47.9 49.1 30.3 11.7 60.7 26.8 17.4 33.2 43.5 54.2 16.5 54.6 27.1 31.1 8.3 9.5 35.1 33.3 23.3 24.0 31.1 40.6 15.7 15.5 20.1 27.5 29.9 60.4 60.7 48.8 25.1 52.8 18.1 48.8 19.7 27.8 22.9 19.4 26.0 42.2 23.2 23.5 31.6 33.4 21.8 23.6 18.3 45.0 16.0 65.1 19.0 20.7 6.9 7.1 10.0 9.2 7.5 8.0 8.1 9.2 8.2 6.7 9.1 8.6 24.3 19.2 17.3 34.0 84.1 12.6 23.7 25.0 16.5 22.3 19.8 16.8 30.3 27.1 21.4 5.5 12.5 40.5 74.7 25.0 35.2 30.6 594.1 20.0 19.4 20.9 7.2 26.9 51.7 44.2 31.7 19.2 17.3 19.2 20.8 77.7 17.5 25.1 23.4 11.8 64.2 29.3 14.2 22.2 63.6 963.6 14.9 33.6 24.9 31.9 30.0 20.7 45.3 54.3 59.4 27.2 27.3 15.8 87.1 27.8 26.0 38.2 25.2 22.7 0.0 26.0 17.9 105.7 52.7 18.8 13.8 56.6 41.1 26.3 30.3 20.6 NHLRC1 "bA204B7.2, EPM2B" ENSG00000187566 "NHL repeat containing E3 ubiquitin protein ligase 1" Q6VVB1 6 18120440-18122677 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, Ubl conjugation pathway" Transferase "Disease variant, Epilepsy, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Erythroid cells: 5.0;Exocrine glandular cells: 3.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "EFO-21: 6.8;K-562: 6.1;SCLC-21H: 6.1" "Low region specificity" "Detected in all" HPA066030 Uncertain Vesicles NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 15: Liver - Metabolism" "Cluster 1: K-562 - Erythropoiesis" "Cluster 4: Macrophages - Innate immune response" Vesicles "HPA066030: " "unprognostic (1.61e-1)" "unprognostic (1.39e-1)" "unprognostic (7.95e-2)" "prognostic unfavorable (9.01e-4)" "unprognostic (6.95e-3)" "unprognostic (2.45e-1)" "unprognostic (1.09e-1)" "unprognostic (3.69e-1)" "unprognostic (2.39e-1)" "unprognostic (7.17e-2)" "unprognostic (5.07e-3)" "unprognostic (1.28e-1)" "unprognostic (2.32e-2)" "unprognostic (3.19e-1)" "unprognostic (2.33e-1)" "unprognostic (2.77e-2)" "prognostic favorable (5.30e-4)" 1.2 1.4 2.0 0.8 2.3 1.1 2.0 1.5 2.6 0.8 0.8 1.5 1.4 0.8 2.6 1.1 1.4 0.6 1.8 2.4 1.9 0.8 4.1 1.2 0.6 2.5 1.8 1.4 1.8 1.2 1.2 0.5 2.7 1.2 1.3 2.0 2.3 1.0 2.6 3.8 1.9 0.8 1.6 1.1 1.3 0.7 2.0 1.0 1.6 1.5 0.8 0.9 0.8 3.6 2.6 1.5 0.6 0.0 1.3 1.2 0.0 2.6 0.8 0.9 0.5 0.1 2.1 0.0 6.8 1.9 0.2 3.0 0.0 1.7 0.7 0.1 0.9 0.4 1.0 0.1 2.0 0.0 1.7 2.1 2.5 1.0 0.9 0.6 2.1 0.0 6.1 0.1 2.1 2.8 0.0 0.0 0.0 0.3 1.5 0.0 0.0 0.1 1.4 2.8 6.1 0.1 5.3 4.3 1.6 0.6 3.1 1.7 0.4 0.2 1.3 1.8 0.1 0.1 0.0 0.1 0.1 0.0 2.6 0.5 4.4 0.4 0.6 4.9 0.8 2.3 1.1 0.5 4.7 1.3 1.5 1.0 0.3 1.6 2.3 0.6 1.3 1.8 2.0 2.3 1.5 2.6 2.4 1.9 2.5 1.8 2.7 1.6 2.0 3.6 0.8 0.0 2.2 0.3 0.2 1.9 1.4 1.4 1.8 0.4 1.5 2.0 0.9 1.5 2.3 0.0 0.0 0.4 0.0 0.2 0.0 2.9 0.0 0.6 1.3 0.3 3.5 5.0 1.0 3.7 0.0 0.8 1.5 0.5 1.3 0.8 0.4 1.1 1.2 0.0 0.7 0.3 0.0 0.8 0.6 0.0 0.6 1.5 1.8 1.0 0.5 1.1 0.0 1.5 1.2 2.0 0.3 0.0 0.0 0.2 0.6 1.2 0.8 1.0 0.0 0.3 0.8 0.2 0.2 1.3 1.8 0.4 0.1 1.1 0.5 0.5 NKTR p104 ENSG00000114857 "Natural killer cell triggering receptor" P30414 3 42600655-42648735 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Isomerase, Rotamase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022120, HPA051576" Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" No No "Cluster 42: Non-specific - Transcription" "Cluster 51: Non-specific - Unknown function" "Cluster 20: HeLa - Mitochondria" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Plasma membrane, Cytosol" "HPA022120: AB_1854513, HPA051576: AB_2681540" "unprognostic (2.73e-3)" "unprognostic (3.11e-1)" "unprognostic (2.33e-1)" "unprognostic (2.06e-1)" "unprognostic (5.27e-3)" "prognostic favorable (1.26e-4)" "unprognostic (4.62e-2)" "unprognostic (5.65e-2)" "unprognostic (4.02e-2)" "unprognostic (1.61e-1)" "unprognostic (5.33e-2)" "prognostic unfavorable (6.01e-4)" "prognostic unfavorable (5.02e-4)" "unprognostic (3.82e-1)" "unprognostic (4.57e-1)" "unprognostic (1.40e-1)" "prognostic favorable (1.05e-5)" 17.4 19.2 16.4 17.6 18.7 46.5 19.3 22.3 17.1 28.4 17.9 17.7 13.2 18.4 22.4 17.0 23.0 11.4 17.8 15.0 20.3 18.2 21.1 23.9 22.1 20.5 16.4 29.0 22.1 10.6 36.5 11.1 17.6 23.2 13.4 41.3 17.5 10.5 19.5 32.6 25.4 10.7 14.0 36.7 16.3 18.0 18.2 15.4 25.4 10.4 20.0 18.3 22.6 27.8 15.1 7.7 32.3 15.6 16.6 19.3 14.9 22.8 6.8 9.9 12.9 14.7 13.3 25.9 10.7 9.1 9.0 12.6 16.1 8.4 19.2 11.0 13.1 31.4 30.5 24.6 7.3 25.4 19.9 9.6 12.2 18.4 10.5 19.1 17.4 7.1 30.3 20.2 18.6 6.9 17.8 35.5 23.1 7.6 12.3 17.3 12.0 10.5 15.7 12.7 9.4 8.5 24.1 11.1 4.8 16.3 17.5 17.8 28.0 18.0 13.1 21.4 23.2 17.2 21.7 17.7 10.1 30.0 11.3 7.8 3.6 7.5 5.7 4.6 5.3 5.5 5.6 4.9 2.9 5.3 5.6 4.9 5.3 7.0 6.8 5.1 5.3 2.3 16.4 18.7 22.3 17.1 15.0 20.3 20.5 16.4 17.6 14.0 18.2 27.8 221.8 109.0 141.4 169.4 129.5 59.0 60.3 57.8 66.0 200.0 76.3 69.8 68.7 65.8 73.2 88.3 246.0 72.5 156.0 60.3 17.6 47.3 23.9 114.4 125.5 166.2 71.8 76.6 143.5 38.8 51.1 83.3 86.6 132.4 96.8 210.0 110.7 58.6 45.9 132.9 170.0 70.2 61.1 53.8 70.2 21.8 167.7 78.9 51.6 194.9 97.4 101.9 163.7 180.0 267.2 47.6 59.2 134.3 131.3 77.5 106.8 17.0 53.3 279.9 92.1 103.5 88.9 246.2 186.1 42.4 57.3 31.3 164.4 104.5 75.0 54.2 NLK ENSG00000087095 "Nemo like kinase" Q9UBE8 17 28041737-28196381 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "retina: 78.6" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 154.3;Early spermatids: 261.1;Excitatory neurons: 315.5;Late spermatids: 355.3;Oligodendrocytes: 366.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 45 "basophil: 29.9" "Lineage enriched" "Detected in single" 45 "granulocytes: 29.9" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018192, HPA056511" Approved Approved "Nucleoplasm,Nucleoli,Cell Junctions" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 58: Brain - Synaptic function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "Nucleoli, Cell Junctions" "HPA018192: AB_1854525, HPA056511: AB_2683160" "unprognostic (7.19e-2)" "unprognostic (1.98e-1)" "unprognostic (5.54e-2)" "unprognostic (5.64e-3)" "unprognostic (2.11e-1)" "unprognostic (1.29e-1)" "unprognostic (1.67e-2)" "unprognostic (2.59e-3)" "unprognostic (2.72e-2)" "unprognostic (4.23e-3)" "unprognostic (1.07e-2)" "unprognostic (1.09e-2)" "unprognostic (5.29e-2)" "unprognostic (1.66e-1)" "unprognostic (3.92e-1)" "unprognostic (5.27e-2)" "unprognostic (6.57e-2)" 8.2 36.6 16.7 8.6 27.6 9.9 9.4 5.7 41.9 7.9 1.0 9.0 10.3 7.0 11.2 5.5 6.4 8.7 11.5 28.5 9.2 16.6 11.1 9.1 16.4 11.9 10.4 5.0 14.3 28.2 11.1 12.2 8.4 8.2 9.2 78.6 7.4 10.8 6.6 5.9 10.2 5.9 6.5 12.2 8.9 22.0 12.2 13.2 16.8 6.7 15.4 10.1 4.5 30.1 9.5 11.6 28.4 9.7 6.1 7.6 12.1 9.6 10.9 16.9 13.1 59.4 9.1 13.6 13.8 8.4 20.2 8.6 19.6 18.7 19.3 29.7 12.2 52.2 11.2 9.9 10.3 11.6 51.0 9.6 11.9 10.4 12.5 16.0 20.4 36.3 20.1 15.9 16.4 11.6 28.8 13.4 10.4 20.1 5.5 23.8 17.2 10.0 32.0 12.2 19.6 7.2 14.4 14.4 62.4 32.2 22.0 18.2 19.2 11.7 14.1 9.0 19.5 17.6 17.9 13.1 11.6 12.6 13.0 29.9 0.3 0.3 0.5 0.4 0.2 0.6 0.5 0.6 0.3 0.3 0.3 0.6 0.2 0.2 0.5 0.5 0.5 0.3 16.7 27.6 5.7 41.9 28.5 9.2 11.9 10.4 8.4 6.5 12.2 30.1 17.8 22.4 6.0 57.8 7.8 5.4 3.8 3.0 5.7 94.4 8.7 5.0 27.4 5.7 5.3 33.1 154.3 3.7 4.3 11.4 1.9 3.9 261.1 8.9 5.8 15.0 28.2 11.8 315.5 6.4 3.5 4.8 5.1 11.9 24.1 17.6 9.3 9.4 8.8 37.0 98.2 10.0 2.0 16.9 6.0 355.3 5.6 11.3 16.0 103.0 7.9 11.2 6.2 104.5 366.6 5.7 8.1 2.6 6.4 5.4 5.1 8.4 9.5 89.9 13.1 5.0 6.9 37.1 11.8 4.1 4.8 6.4 5.5 6.7 10.3 6.6 NLN "AGTBP, KIAA1226" ENSG00000123213 Neurolysin Q9BYT8 5 65722205-65871725 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 52.8;Excitatory neurons: 58.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 5 "classical monocyte: 2.6;intermediate monocyte: 3.4;myeloid DC: 2.2;non-classical monocyte: 2.3" "Group enriched" "Detected in many" 5 "dendritic cells: 2.2;monocytes: 3.4" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031862 Approved Approved Mitochondria Yes No 64000 "Cluster 7: Monocytes - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 25: RPMI-8226 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Mitochondria "HPA031862: AB_10600827" "unprognostic (5.91e-3)" "unprognostic (4.52e-2)" "unprognostic (1.34e-3)" "unprognostic (4.37e-2)" "unprognostic (3.85e-1)" "unprognostic (1.45e-2)" "unprognostic (7.29e-3)" "unprognostic (3.24e-2)" "unprognostic (3.19e-1)" "unprognostic (3.58e-1)" "prognostic unfavorable (7.51e-4)" "unprognostic (1.27e-1)" "prognostic favorable (5.58e-7)" "unprognostic (1.52e-2)" "unprognostic (1.98e-1)" "unprognostic (1.29e-1)" "unprognostic (6.18e-3)" 2.2 1.0 3.8 2.4 3.9 1.5 3.7 2.9 5.3 1.8 1.6 3.6 1.1 2.7 2.4 2.5 1.5 1.2 2.6 3.8 3.6 3.9 9.9 1.7 1.7 3.9 3.4 1.8 2.5 1.5 0.9 2.4 4.0 2.6 3.2 2.5 1.9 1.1 8.9 2.8 2.7 2.7 3.3 1.3 4.0 1.1 3.9 0.9 2.7 6.5 2.0 2.7 1.5 4.8 13.3 12.5 7.2 12.0 9.0 15.3 14.5 13.1 5.5 7.6 8.2 7.2 7.7 18.8 16.1 15.8 15.1 10.3 9.5 20.2 13.1 5.6 6.4 5.2 8.7 18.5 7.7 12.0 3.0 11.7 10.8 10.5 12.4 6.3 21.7 8.3 11.4 3.9 16.5 10.2 8.3 10.8 22.2 6.7 3.6 9.6 15.3 29.9 12.6 5.9 22.3 11.5 10.6 10.7 11.0 19.4 12.9 14.1 12.5 5.0 5.9 7.4 10.0 3.3 7.1 8.2 7.7 23.2 7.7 0.1 2.6 0.1 0.1 3.4 0.1 0.4 0.2 0.1 2.2 0.4 0.3 0.2 0.3 0.5 2.3 0.1 0.0 1.0 3.8 3.9 2.9 5.3 3.8 3.6 3.9 3.4 4.0 3.3 3.9 4.8 5.9 6.4 2.8 19.6 4.0 5.7 9.0 6.2 8.6 2.4 10.1 8.9 14.5 7.2 8.5 12.9 4.2 5.3 0.6 52.8 5.9 17.8 0.3 7.4 12.9 8.3 1.8 9.0 58.9 14.5 14.0 7.1 20.4 20.9 15.2 16.2 4.6 32.4 28.8 5.0 32.2 5.8 6.1 22.9 8.9 0.4 4.4 13.5 1.8 5.6 17.9 13.1 2.1 22.6 44.5 30.2 35.9 2.2 4.9 16.5 32.3 22.4 3.1 4.7 0.0 19.7 8.1 2.1 5.2 15.3 5.3 2.9 2.3 15.8 8.2 6.1 NMT1 NMT ENSG00000136448 "N-myristoyltransferase 1" P30419 17 44957992-45109016 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hepatocytes: 344.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022949, HPA022963" Supported Supported "Plasma membrane,Cytosol" NA NA 94000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 39: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 2: Hepatocytes - Metabolism" Cytosol "Plasma membrane" "HPA022949: AB_1854534, HPA022963: AB_1854535" "unprognostic (1.40e-1)" "unprognostic (2.87e-1)" "unprognostic (1.30e-2)" "unprognostic (6.14e-2)" "unprognostic (1.65e-1)" "unprognostic (1.64e-1)" "prognostic unfavorable (4.94e-4)" "unprognostic (4.96e-3)" "unprognostic (3.86e-1)" "unprognostic (3.04e-2)" "unprognostic (2.19e-1)" "unprognostic (1.98e-1)" "unprognostic (3.77e-3)" "unprognostic (1.01e-2)" "unprognostic (4.89e-2)" "unprognostic (4.17e-3)" "unprognostic (9.45e-2)" 28.3 31.8 36.2 22.3 37.7 19.5 25.8 30.3 43.4 24.7 27.9 27.8 23.6 26.4 15.7 28.8 27.7 20.3 28.3 38.8 36.4 27.3 39.5 26.5 33.6 35.4 33.7 26.3 22.2 37.8 23.3 36.6 35.0 24.5 29.2 25.7 32.1 27.6 44.6 23.9 26.4 32.9 33.9 28.4 24.5 24.9 37.2 35.2 30.7 47.6 39.5 33.0 23.5 34.9 51.5 88.8 53.7 42.3 82.9 75.0 60.6 41.4 87.6 115.9 101.0 83.9 57.0 54.0 86.2 80.4 78.4 51.5 94.5 92.3 132.9 117.9 73.3 49.0 60.7 84.4 53.7 71.0 62.6 66.4 64.1 79.1 69.2 64.1 87.1 60.9 81.8 38.1 63.1 49.2 76.2 31.7 42.4 151.5 87.8 57.5 67.2 52.2 73.6 78.8 39.2 32.9 33.0 30.2 38.0 112.8 73.1 46.0 50.1 69.9 49.5 55.8 68.1 41.4 61.0 69.9 64.5 44.5 56.4 34.9 49.4 20.0 23.8 33.3 19.9 42.3 19.9 20.1 26.2 31.0 23.7 18.8 26.5 21.1 27.6 115.5 25.7 11.8 36.2 37.7 30.3 43.4 38.8 36.4 35.4 33.7 35.0 33.9 37.2 34.9 50.1 38.5 29.5 49.3 53.8 13.9 15.4 48.8 24.5 97.8 74.1 57.1 46.5 97.2 33.6 69.9 116.7 73.7 87.5 48.7 78.2 69.4 31.1 51.5 63.1 46.4 50.9 72.0 30.3 71.2 61.9 39.6 21.9 62.3 22.8 28.1 85.3 344.4 47.6 129.5 30.7 43.0 28.5 86.5 15.9 12.2 55.0 34.6 10.6 18.7 97.9 41.5 59.8 20.1 19.3 67.9 52.0 51.1 31.0 15.3 84.1 108.1 24.0 123.5 59.2 16.1 46.3 67.6 35.5 20.5 14.1 81.8 40.1 25.4 68.6 18.6 NMT2 ENSG00000152465 "N-myristoyltransferase 2" O60551 10 15102584-15168693 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "granulocytes: 93.6;Hepatocytes: 141.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 7 "basophil: 14.5;eosinophil: 13.6;gdT-cell: 11.0;MAIT T-cell: 19.8;memory CD4 T-cell: 17.5;memory CD8 T-cell: 12.9;naive CD4 T-cell: 21.8;naive CD8 T-cell: 14.5;NK-cell: 20.8;T-reg: 29.5" "Group enriched" "Detected in many" 8 "granulocytes: 14.5;NK-cells: 20.8;T-cells: 29.5" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 102.6;TIME: 147.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001303 Approved Supported "Golgi apparatus,Plasma membrane,Cytosol" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 2: Hepatocytes - Metabolism" "Golgi apparatus, Plasma membrane, Cytosol" "HPA001303: AB_1079494" "unprognostic (1.08e-1)" "unprognostic (7.65e-2)" "unprognostic (8.78e-2)" "unprognostic (1.15e-3)" "unprognostic (6.97e-2)" "unprognostic (2.24e-1)" "unprognostic (7.11e-2)" "unprognostic (5.13e-2)" "unprognostic (3.20e-1)" "unprognostic (4.01e-3)" "unprognostic (3.31e-1)" "unprognostic (2.00e-1)" "unprognostic (7.06e-2)" "unprognostic (3.79e-3)" "unprognostic (2.00e-1)" "unprognostic (1.03e-1)" "unprognostic (1.16e-1)" 25.9 4.4 7.3 6.1 8.7 3.7 17.5 12.2 10.0 9.8 4.0 8.8 6.6 12.7 3.5 7.0 8.3 7.0 8.7 7.0 4.9 9.4 16.8 6.3 8.9 5.0 7.6 15.4 5.6 16.5 5.5 4.4 5.1 9.0 9.2 7.0 5.2 7.7 8.3 10.1 10.9 10.5 4.3 9.4 7.9 13.4 9.1 27.0 5.9 8.5 8.0 8.6 7.9 7.3 8.8 11.3 12.7 9.3 33.7 35.9 2.3 18.8 15.3 17.0 23.0 10.9 38.7 0.4 12.7 102.6 46.6 10.6 11.4 10.7 28.3 11.7 13.9 23.4 5.4 15.2 22.4 1.7 84.0 31.9 10.8 23.8 7.2 62.2 65.8 16.3 11.2 1.5 63.7 10.9 18.3 4.4 9.3 10.0 10.5 13.6 18.5 1.8 12.6 1.8 3.9 14.4 22.8 3.7 6.3 10.5 11.7 7.3 147.1 16.7 24.4 75.0 13.7 13.0 14.3 1.0 20.7 6.3 12.4 14.5 0.5 13.6 11.0 0.7 19.8 2.2 17.5 12.9 0.5 2.5 21.8 14.5 1.9 20.8 0.8 0.5 29.5 6.5 7.3 8.7 12.2 10.0 7.0 4.9 5.0 7.6 5.1 4.3 9.1 7.3 52.5 9.6 8.8 25.1 16.0 16.6 23.4 8.3 7.4 20.6 14.7 13.1 13.5 57.2 10.9 27.6 4.2 1.3 16.9 32.8 9.8 33.9 6.6 4.7 20.5 21.7 18.0 15.1 39.6 19.5 3.0 16.3 9.2 10.3 93.6 13.2 25.4 141.9 2.8 20.2 30.1 11.4 4.1 7.9 7.1 14.5 21.8 5.8 12.4 17.8 10.1 12.9 40.2 12.5 15.3 27.1 15.9 20.7 10.0 17.9 38.4 63.2 5.3 17.2 0.0 13.4 21.0 8.1 46.8 6.8 14.8 2.6 33.9 11.0 18.1 16.7 NOL9 "FLJ23323, Grc3, NET6" ENSG00000162408 "Nucleolar protein 9" Q5SY16 1 6521347-6554513 "Metabolic proteins, Predicted intracellular proteins" "rRNA processing" "Kinase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036347 Supported "Nucleoli,Intermediate filaments" NA NA "Cluster 30: Non-specific - Translation" "Cluster 2: Immune cells - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 59: Non-specific - Transcription" Nucleoli "Intermediate filaments" "HPA036347: AB_2675076" "unprognostic (3.03e-1)" "unprognostic (4.93e-2)" "unprognostic (4.99e-2)" "unprognostic (3.14e-3)" "unprognostic (2.12e-1)" "unprognostic (1.30e-1)" "prognostic unfavorable (3.69e-5)" "unprognostic (2.48e-1)" "unprognostic (1.31e-1)" "unprognostic (8.90e-2)" "unprognostic (1.44e-3)" "unprognostic (2.32e-1)" "unprognostic (3.80e-2)" "unprognostic (3.32e-2)" "unprognostic (3.40e-1)" "unprognostic (3.54e-2)" "unprognostic (4.65e-2)" 3.8 4.6 4.5 3.5 5.0 7.5 3.7 4.9 5.6 4.7 1.9 5.0 2.4 5.0 3.6 4.7 4.3 2.3 4.5 6.2 4.2 4.4 5.3 3.2 5.2 3.3 3.8 4.8 6.0 3.4 4.0 3.0 3.8 4.1 3.1 4.3 3.6 3.1 7.0 6.0 4.8 3.9 2.7 8.8 4.5 3.7 4.6 3.8 3.4 4.5 5.1 4.5 3.8 4.0 6.4 9.1 5.0 15.2 6.6 4.0 5.4 6.3 4.1 6.4 6.8 12.6 8.6 17.9 7.3 7.1 5.5 8.3 10.2 8.6 10.9 7.3 5.5 12.2 14.7 9.9 6.6 10.4 6.4 5.8 2.6 13.6 11.8 3.7 7.6 7.8 14.3 7.3 6.6 11.2 10.2 9.2 6.9 5.0 8.7 12.7 11.7 8.3 5.1 5.8 9.7 4.4 9.7 12.1 8.1 5.1 7.9 4.8 10.0 10.1 8.1 7.2 10.6 6.1 6.2 31.9 9.4 11.4 4.9 3.5 1.9 1.6 3.1 1.9 3.2 2.9 4.5 2.9 1.3 3.7 4.6 3.8 1.2 1.7 3.2 3.5 3.2 1.2 4.5 5.0 4.9 5.6 6.2 4.2 3.3 3.8 3.8 2.7 4.6 4.0 15.0 19.2 19.5 9.4 16.2 15.4 6.9 6.9 10.8 17.1 9.8 13.2 15.0 11.5 7.4 7.3 14.6 14.8 17.3 6.7 15.6 8.9 6.0 13.7 19.7 15.2 6.7 11.6 18.9 8.6 12.6 15.3 11.7 15.6 5.1 18.3 14.3 13.2 9.1 10.1 18.5 10.9 4.1 13.8 7.3 17.0 9.6 8.6 1.8 10.3 13.4 8.1 12.3 13.0 20.1 9.0 6.2 12.8 17.9 7.3 7.6 10.7 9.0 18.2 0.0 22.6 12.7 11.7 21.5 16.0 14.8 12.7 17.3 19.1 13.2 7.3 NQO1 "DHQU, DIA4, DTD, NMOR1, QR1" ENSG00000181019 "NAD(P)H quinone dehydrogenase 1" P15559 16 69706996-69726668 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" Oxidoreductase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "stomach 1: 522.7" "Cell type enhanced" "Detected in many" "Gastric mucus-secreting cells: 539.8;Respiratory ciliated cells: 471.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "A549: 2434.0;OE19: 4177.0;SiHa: 2756.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007308, CAB012421" Enhanced Supported Cytosol NA NA 490000 "Cluster 48: NK-cells - Unknown function" "Cluster 22: Non-specific - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 49: Ciliated cells - Cilium organization" Cytosol "CAB012421: , HPA007308: AB_1079501" "unprognostic (1.04e-2)" "unprognostic (1.95e-3)" "unprognostic (3.14e-1)" "unprognostic (3.76e-3)" "unprognostic (9.03e-2)" "prognostic unfavorable (1.45e-4)" "unprognostic (1.05e-3)" "unprognostic (1.97e-1)" "unprognostic (5.07e-2)" "unprognostic (1.24e-2)" "unprognostic (1.49e-2)" "unprognostic (2.25e-1)" "unprognostic (2.41e-2)" "unprognostic (6.36e-2)" "unprognostic (1.45e-1)" "unprognostic (1.98e-1)" "unprognostic (3.27e-1)" 100.9 95.1 88.9 20.7 97.2 0.8 264.8 88.1 165.6 24.3 113.4 85.6 106.8 16.1 27.2 162.2 29.3 183.1 24.3 86.7 95.0 93.9 5.6 36.5 4.8 83.5 86.2 8.9 9.2 19.5 15.3 12.0 85.9 20.7 74.0 21.4 47.7 25.1 34.2 11.7 56.1 35.0 83.0 22.8 522.7 6.4 93.6 4.3 112.7 27.0 16.5 79.0 34.2 86.8 224.2 2434.0 203.4 901.3 473.1 682.7 77.5 363.1 632.7 363.9 547.0 302.0 1395.7 7.1 433.1 1850.6 634.3 232.1 79.1 410.3 185.2 91.3 3.3 10.9 564.4 2169.9 631.7 53.8 170.6 166.2 246.8 642.8 74.4 537.9 903.9 18.5 95.3 16.3 1914.1 725.9 11.6 98.7 107.0 4177.0 237.1 18.9 44.0 101.6 708.3 781.5 73.0 17.2 2756.6 384.8 1690.4 226.6 631.3 173.1 626.5 368.8 155.8 140.0 297.1 12.7 53.1 11.2 470.2 29.1 1864.0 1.1 3.9 0.3 6.3 0.4 3.1 5.7 7.3 8.3 3.8 2.4 2.2 5.3 0.9 18.7 0.4 1.3 15.6 5.1 88.9 97.2 88.1 165.6 86.7 95.0 83.5 86.2 85.9 83.0 93.6 86.8 88.5 25.6 14.6 8.8 2.9 5.2 26.4 185.5 32.5 10.0 31.1 30.5 4.8 138.7 90.9 42.3 4.2 1.7 3.5 165.7 146.8 25.6 0.4 117.2 11.7 81.0 20.4 1.3 1.9 147.5 4.3 32.9 539.8 65.7 19.7 10.1 28.5 2.6 15.2 3.3 1.6 81.7 107.8 3.5 7.6 1.2 25.1 10.9 17.8 4.7 128.5 10.6 7.2 0.0 5.0 75.1 59.4 12.0 2.3 22.6 62.9 44.3 471.3 15.1 6.6 21.1 72.1 0.3 1.3 128.3 4.5 1.9 5.6 17.3 51.5 40.6 NQO2 "DHQV, DIA6, NMOR2, QR2" ENSG00000124588 "N-ribosyldihydronicotinamide:quinone reductase 2" P16083 6 2987987-3019755 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hepatocytes: 202.5;Proximal tubular cells: 730.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 240.2" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021283, HPA021332" Enhanced Supported Nucleoplasm,Cytosol NA NA 6000000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 39: Non-specific - Mitochondria" "Cluster 16: U-266 - Nucleosome" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Cytosol Nucleoplasm "HPA021283: AB_1854600, HPA021332: AB_1854601" "unprognostic (7.11e-3)" "unprognostic (1.43e-3)" "unprognostic (2.41e-1)" "unprognostic (3.01e-2)" "unprognostic (1.00e-2)" "unprognostic (3.58e-1)" "prognostic unfavorable (8.40e-4)" "unprognostic (1.77e-1)" "unprognostic (1.15e-1)" "unprognostic (4.90e-2)" "unprognostic (6.59e-2)" "unprognostic (3.60e-2)" "unprognostic (8.28e-2)" "unprognostic (2.03e-1)" "unprognostic (3.32e-2)" "unprognostic (3.96e-1)" "unprognostic (2.02e-1)" 60.0 121.5 48.1 27.0 48.8 72.1 45.0 61.1 65.4 32.6 64.3 28.2 35.3 25.8 32.9 32.8 30.0 31.5 76.5 48.5 49.6 190.3 124.2 30.4 19.5 61.8 47.9 29.8 42.6 33.5 21.2 28.6 61.4 28.1 19.6 31.1 61.9 28.9 123.6 50.7 35.6 19.8 42.9 39.3 36.1 18.2 51.5 18.3 26.8 144.9 18.2 31.8 29.0 53.2 45.7 75.7 42.1 95.3 73.0 42.9 45.4 40.5 51.2 37.1 40.9 80.0 16.1 36.9 144.7 71.1 86.4 33.7 45.4 28.5 28.9 95.9 37.1 23.6 83.0 77.3 59.7 24.4 73.9 27.8 34.2 44.9 40.9 53.4 36.8 47.9 142.3 24.1 30.8 95.5 27.0 44.4 54.9 87.6 59.8 49.3 50.1 108.2 56.6 24.0 11.4 15.9 59.5 25.9 128.9 75.0 35.4 16.9 60.7 34.8 14.4 45.9 18.1 45.4 116.7 12.3 43.3 69.5 72.7 25.2 91.8 52.8 33.1 64.2 24.4 12.1 29.6 29.8 61.7 9.1 17.8 19.6 240.2 30.0 60.8 6.5 37.2 43.2 48.1 48.8 61.1 65.4 48.5 49.6 61.8 47.9 61.4 42.9 51.5 53.2 30.3 9.6 16.1 9.8 16.3 35.2 41.5 32.7 12.5 34.8 34.2 32.1 72.8 47.1 21.3 25.8 10.4 42.6 18.2 21.2 162.4 29.1 51.6 15.1 21.4 28.0 4.8 43.8 47.0 63.4 53.9 51.5 33.1 9.0 13.9 11.0 25.7 202.5 76.6 42.1 46.7 23.3 30.5 44.7 105.7 62.8 35.8 75.4 67.6 19.7 148.6 54.0 20.6 10.6 9.1 55.8 18.3 41.0 15.0 38.6 103.7 730.3 28.7 22.5 26.3 35.0 42.9 24.8 11.4 35.4 41.2 31.2 20.8 21.9 25.4 41.8 NR1D1 "ear-1, hRev, Rev-ErbAalpha, REVERBA, REVERBalpha, THRA1, THRAL" ENSG00000126368 "Nuclear receptor subfamily 1 group D member 1" P20393 17 40092793-40100589 "Metabolic proteins, Nuclear receptors, Predicted intracellular proteins, Transcription factors" "Biological rhythms, Differentiation, Transcription, Transcription regulation" "Activator, DNA-binding, Receptor, Repressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skin 1: 325.5" "Cell type enhanced" "Detected in all" "Squamous epithelial cells: 95.5;Suprabasal keratinocytes: 81.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "MAIT T-cell: 18.5" "Group enriched" "Detected in many" 6 "monocytes: 5.5;T-cells: 18.5" "Cell line enhanced" "Detected in all" "Karpas-707: 60.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007935 Uncertain Supported "Nuclear bodies" NA Yes "Cluster 16: MAIT-cells - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 2: Karpas-707 - Immune response" "Cluster 61: Squamous epithelial cells - Keratinization" "Nuclear bodies" "HPA007935: AB_10601277" "unprognostic (1.38e-2)" "unprognostic (3.46e-2)" "prognostic unfavorable (1.94e-4)" "unprognostic (2.53e-1)" "unprognostic (2.24e-2)" "unprognostic (1.05e-1)" "unprognostic (4.50e-2)" "unprognostic (1.03e-1)" "prognostic favorable (1.36e-4)" "unprognostic (1.93e-3)" "unprognostic (9.93e-3)" "unprognostic (2.73e-1)" "unprognostic (9.15e-3)" "unprognostic (4.54e-3)" "unprognostic (2.49e-1)" "unprognostic (3.09e-1)" "unprognostic (1.34e-1)" 72.3 53.7 23.5 6.3 27.0 5.4 63.1 52.9 49.7 109.6 10.6 53.3 14.3 35.8 4.5 42.5 27.7 7.1 60.8 24.9 17.2 38.0 43.2 49.2 9.3 18.1 20.9 71.3 24.3 9.0 32.0 6.0 15.9 40.5 4.0 50.4 52.9 16.3 99.0 325.5 23.0 7.5 12.9 11.6 31.5 12.5 34.0 6.3 32.1 38.1 5.4 42.5 96.5 25.2 5.5 7.8 1.6 6.2 9.0 6.2 2.2 11.9 19.5 3.9 4.9 5.1 19.5 6.7 6.9 13.8 12.9 15.4 4.1 18.0 2.9 5.6 4.1 4.8 7.9 13.5 14.6 7.2 6.9 13.5 12.8 13.3 28.2 12.6 4.9 7.7 7.2 60.6 3.8 3.8 10.7 6.1 3.0 10.8 12.3 7.5 2.2 20.7 5.4 4.9 5.1 2.9 7.6 9.7 12.4 2.7 4.6 5.8 4.7 17.2 16.7 14.1 9.5 21.5 35.7 2.6 23.4 4.0 13.6 0.0 0.5 0.0 4.4 2.0 18.5 1.7 5.5 6.4 1.1 2.1 4.8 3.5 0.2 1.0 5.5 1.4 8.0 1.8 23.5 27.0 52.9 49.7 24.9 17.2 18.1 20.9 15.9 12.9 34.0 25.2 16.4 3.2 2.0 17.3 5.7 64.5 47.5 20.5 67.2 71.4 9.4 15.1 5.7 8.6 11.9 1.8 4.2 2.6 4.9 26.0 7.9 16.1 2.3 25.4 30.6 18.6 8.3 3.6 7.1 11.8 1.2 26.5 31.1 64.2 2.5 2.7 6.8 31.8 2.5 42.1 6.2 7.2 8.2 3.4 19.4 1.5 21.8 7.7 19.6 8.4 1.2 39.0 5.2 5.0 1.2 26.0 14.7 38.7 10.5 35.4 58.8 7.9 5.0 29.7 6.6 9.6 19.4 2.0 11.1 95.5 81.1 2.3 11.9 13.7 6.0 28.7 NRF1 "ALPHA-PAL, EWG" ENSG00000106459 "Nuclear respiratory factor 1" Q16656 7 129611720-129757082 "Metabolic proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 7 "Astrocytes: 127.0;Excitatory neurons: 115.4;Inhibitory neurons: 109.4;Microglial cells: 75.9;Oligodendrocyte precursor cells: 143.2;Oligodendrocytes: 122.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029329 Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm Cytosol "HPA029329: AB_10601240" "unprognostic (2.80e-2)" "unprognostic (2.20e-3)" "unprognostic (4.51e-1)" "unprognostic (4.04e-2)" "unprognostic (2.01e-1)" "unprognostic (4.20e-3)" "prognostic unfavorable (6.02e-4)" "unprognostic (1.09e-1)" "unprognostic (2.13e-2)" "unprognostic (3.69e-2)" "unprognostic (1.18e-3)" "unprognostic (2.99e-3)" "unprognostic (1.83e-2)" "unprognostic (2.06e-1)" "unprognostic (6.52e-2)" "unprognostic (4.20e-1)" "unprognostic (2.06e-3)" 8.3 5.6 9.2 7.9 9.9 16.7 7.9 13.3 11.1 10.8 11.5 8.8 6.4 9.9 6.4 7.2 12.8 5.5 9.4 9.3 10.7 9.0 6.1 8.0 12.3 11.1 10.6 16.6 7.3 8.5 7.7 7.0 10.1 8.0 6.8 12.7 7.5 6.2 15.6 9.3 8.3 7.7 9.1 10.3 6.7 5.6 10.2 18.0 9.7 8.8 11.1 8.7 8.0 13.0 15.9 12.8 18.1 15.9 10.7 8.5 14.4 10.9 11.2 16.3 12.6 15.6 10.4 18.3 7.8 12.3 10.2 11.9 19.7 11.0 16.5 17.5 14.1 15.1 11.0 10.3 7.8 18.7 14.5 7.3 10.2 16.1 15.5 9.4 12.1 17.4 18.6 13.7 10.1 14.5 36.9 17.6 16.9 14.5 11.3 23.2 14.6 16.2 9.2 11.5 15.6 17.1 16.4 16.8 11.0 14.7 10.5 17.4 9.4 9.2 12.6 10.8 20.3 14.7 15.7 32.0 9.7 17.0 18.1 5.6 4.2 10.6 8.2 5.2 9.8 5.5 6.3 7.7 5.5 5.9 6.8 6.0 8.8 5.0 5.8 3.6 7.2 5.8 9.2 9.9 13.3 11.1 9.3 10.7 11.1 10.6 10.1 9.1 10.2 13.0 6.8 3.2 6.5 127.0 15.8 6.6 3.2 3.4 4.6 10.8 5.4 5.1 6.2 2.8 4.8 3.7 10.4 2.8 11.3 5.5 0.0 2.3 0.4 8.9 6.4 7.1 6.7 3.0 115.4 3.6 4.1 6.0 7.1 5.7 5.1 6.9 7.1 4.1 3.1 10.1 109.4 5.3 4.1 7.7 9.5 1.9 5.3 5.4 5.4 75.9 4.0 6.4 12.3 143.2 122.3 3.0 10.2 4.5 14.2 6.8 3.7 2.3 13.1 11.2 6.6 10.0 6.4 9.0 6.6 6.2 7.7 3.4 13.8 2.3 4.2 5.4 NUAK1 "ARK5, KIAA0537" ENSG00000074590 "NUAK family kinase 1" O60285 12 106063345-106138954 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell adhesion, DNA damage" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endothelial cells: 111.7;Excitatory neurons: 150.5;Hepatic stellate cells: 136.3;Microglial cells: 93.7;Oligodendrocytes: 73.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 58.0;EFO-21: 55.1;RH-30: 77.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA057143 Approved "Nucleoplasm,Nucleoli fibrillar center,Microtubules" Yes No "Cluster 47: Non-specific - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoli fibrillar center" "Nucleoplasm, Microtubules" "HPA057143: AB_2683349" "unprognostic (4.20e-2)" "unprognostic (8.42e-2)" "unprognostic (3.71e-2)" "prognostic unfavorable (9.83e-4)" "unprognostic (4.13e-2)" "unprognostic (2.34e-1)" "unprognostic (1.43e-1)" "unprognostic (4.80e-2)" "unprognostic (9.91e-2)" "unprognostic (4.06e-3)" "unprognostic (3.29e-1)" "unprognostic (1.31e-1)" "unprognostic (1.93e-3)" "prognostic unfavorable (4.27e-4)" "unprognostic (2.31e-1)" "unprognostic (8.70e-2)" "unprognostic (4.47e-2)" 17.5 3.6 12.6 2.3 17.5 0.6 12.1 9.4 25.4 9.8 0.0 4.1 2.2 9.5 3.1 3.5 9.0 4.9 18.8 17.4 5.6 4.2 4.0 9.3 3.2 6.1 5.9 6.1 3.2 17.5 2.7 4.5 8.3 6.0 3.9 5.4 3.4 6.0 20.6 20.8 4.3 10.2 5.5 0.8 3.8 2.6 5.5 3.3 4.3 17.2 2.3 4.8 8.1 31.8 13.0 8.3 58.0 0.6 23.7 2.5 27.0 14.2 9.5 9.9 8.0 4.3 2.1 0.0 55.1 27.4 5.0 11.9 12.6 11.2 4.8 0.2 3.4 0.0 9.7 4.7 5.0 0.1 0.1 11.0 8.1 6.0 1.7 19.2 21.2 0.1 0.0 40.3 7.8 1.3 0.2 0.6 11.1 0.2 3.3 0.1 77.7 10.5 6.6 13.3 6.8 0.4 6.9 1.9 0.5 37.2 2.9 0.4 16.6 9.4 29.7 3.3 17.0 0.0 0.0 0.7 2.8 0.0 9.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 12.6 17.5 9.4 25.4 17.4 5.6 6.1 5.9 8.3 5.5 5.5 31.8 56.4 0.0 2.4 15.7 0.6 13.5 32.9 29.8 10.2 32.3 2.1 4.2 48.9 10.0 7.2 7.3 0.0 0.8 13.5 0.9 3.9 6.2 0.4 5.1 6.6 111.7 0.0 5.3 150.5 9.6 5.2 17.9 2.0 3.8 0.0 2.9 136.3 12.1 8.0 40.4 55.4 2.3 12.2 8.4 8.8 2.6 4.1 1.3 10.6 93.7 0.6 1.9 1.0 15.6 73.5 18.4 0.5 3.0 3.2 10.6 0.2 1.8 2.2 2.9 0.0 7.1 26.4 1.0 5.5 2.5 15.9 0.3 2.7 0.4 0.8 5.2 NUAK2 "FLJ90349, SNARK" ENSG00000163545 "NUAK family kinase 2" Q9H093 1 205302063-205321745 "Enzymes, Metabolic proteins, Predicted membrane proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 56.7;vagina: 45.3" "Cell type enhanced" "Detected in many" "Ductal cells: 46.9;Endometrial ciliated cells: 45.3;Glandular and luminal cells: 52.4;Intestinal goblet cells: 43.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 120.4" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BEWO: 44.1;RPMI-8226: 36.1;RPTEC TERT1: 40.9;SuSa: 45.6" "Low region specificity" "Detected in many" "Not detected" "Not detected" HPA008958 Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Cytosol" "HPA008958: AB_1080040" "unprognostic (2.24e-2)" "unprognostic (6.33e-2)" "unprognostic (1.17e-1)" "prognostic unfavorable (3.01e-7)" "unprognostic (8.24e-3)" "unprognostic (1.58e-2)" "unprognostic (3.00e-2)" "unprognostic (1.08e-2)" "unprognostic (1.74e-1)" "unprognostic (9.19e-2)" "prognostic favorable (7.94e-6)" "unprognostic (3.71e-2)" "unprognostic (3.17e-2)" "unprognostic (4.90e-2)" "unprognostic (5.80e-2)" "unprognostic (4.54e-2)" "unprognostic (1.61e-1)" 2.1 3.7 1.3 7.7 1.9 11.4 0.9 4.6 1.7 31.0 3.2 8.0 16.5 1.6 1.3 56.7 4.0 1.7 1.2 1.2 1.3 28.2 5.1 10.3 11.5 2.1 1.8 1.3 16.0 0.8 3.0 4.4 2.0 1.9 8.8 0.5 15.1 1.6 0.7 22.4 12.5 1.2 1.4 13.1 2.5 3.7 2.2 3.9 16.1 1.1 8.0 3.1 45.3 4.1 4.3 23.1 13.7 0.6 0.3 0.6 44.1 5.5 5.7 14.7 5.9 24.4 0.8 7.0 3.2 1.5 24.1 8.3 3.2 8.3 6.3 0.0 0.4 0.0 1.4 4.2 9.3 0.0 0.1 2.6 6.1 8.6 5.0 3.3 0.7 0.0 0.9 1.7 2.8 1.0 0.0 0.1 8.9 3.1 0.7 0.0 1.0 36.1 40.9 0.1 2.1 0.2 1.6 6.5 0.7 45.6 6.6 0.1 1.7 5.3 2.5 0.6 8.7 12.1 2.0 4.4 0.8 0.0 2.1 11.2 16.5 40.1 10.3 11.8 7.6 37.9 12.7 12.3 10.4 39.3 27.9 21.9 120.4 17.5 13.1 4.1 8.1 17.4 1.3 1.9 4.6 1.7 1.2 1.3 2.1 1.8 2.0 1.4 2.2 4.1 2.0 6.4 6.8 0.3 28.0 1.1 3.2 3.7 13.1 1.1 1.9 2.2 2.7 20.0 2.9 33.1 0.0 9.2 7.1 34.9 5.9 46.9 2.0 45.3 7.5 5.9 10.8 2.7 0.1 1.8 29.1 3.7 7.7 52.4 0.0 2.4 0.7 2.6 4.7 0.0 0.4 43.0 18.3 12.3 11.1 2.1 0.0 8.9 7.2 3.7 38.5 1.3 18.6 0.5 3.5 6.9 7.8 0.0 18.5 2.5 18.3 17.2 7.7 0.5 6.6 2.4 5.5 0.9 1.1 21.5 5.4 4.1 5.7 0.5 22.0 0.5 NUDT10 "DIPP3a, hDIPP3alpha" ENSG00000122824 "Nudix hydrolase 10" Q8NFP7 X 51332231-51337525 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 26.3" "Group enriched" "Detected in many" 5 "Hepatic stellate cells: 60.3;Peritubular cells: 29.0" "Group enriched" "Detected in many" 6 "glioma: 5.0;prostate cancer: 5.4;testis cancer: 7.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 7.5;HAP1: 14.2;HEK 293: 10.5;NTERA-2: 25.8;SH-SY5Y: 5.6;U-2 OS: 12.7" "HPA047027, HPA057684" Approved Approved Cytosol NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 5: NTERA-2 - Transcription" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Cytosol "HPA047027: AB_2679907, HPA057684: AB_2683501" "unprognostic (2.61e-2)" "unprognostic (1.12e-2)" "unprognostic (7.40e-3)" "unprognostic (7.84e-2)" "unprognostic (1.82e-1)" "unprognostic (2.51e-2)" "unprognostic (1.16e-1)" "unprognostic (2.06e-1)" "unprognostic (2.54e-2)" "unprognostic (1.11e-1)" "unprognostic (2.49e-2)" "unprognostic (1.27e-1)" "unprognostic (1.51e-3)" "unprognostic (1.80e-3)" "unprognostic (1.04e-2)" "unprognostic (1.12e-2)" "unprognostic (5.04e-5)" 0.6 1.6 11.2 0.8 9.8 1.5 0.8 3.8 9.8 6.2 2.3 3.1 0.5 5.3 16.1 1.0 3.6 1.4 1.0 9.2 10.0 3.9 1.3 0.3 0.3 5.0 7.1 16.9 0.3 0.0 2.1 0.0 7.1 14.9 0.7 1.5 0.5 14.6 0.1 0.4 1.0 4.1 4.1 3.4 1.2 26.3 11.9 0.4 0.6 0.2 0.3 3.9 3.6 9.3 0.0 0.0 7.5 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 1.2 0.0 14.2 0.6 0.0 0.0 10.5 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 25.8 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 5.6 0.0 0.0 0.0 5.1 0.0 0.0 0.0 0.0 12.7 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 11.2 9.8 3.8 9.8 9.2 10.0 5.0 7.1 7.1 4.1 11.9 9.3 0.2 0.0 1.3 0.7 0.2 1.0 4.9 0.6 1.8 0.5 0.1 1.5 0.2 0.0 0.6 0.0 0.0 0.7 0.4 0.0 0.0 0.0 1.5 0.7 3.5 2.5 0.0 0.8 5.0 0.0 1.0 3.1 0.0 0.1 0.0 5.0 60.3 0.3 0.2 0.0 1.9 0.0 0.0 1.9 0.4 6.2 5.9 0.1 1.8 1.0 0.0 1.7 0.0 3.5 0.6 0.0 0.0 29.0 1.4 2.8 0.0 0.1 0.0 0.5 0.0 1.5 1.9 3.8 7.8 0.4 0.1 0.4 0.2 0.9 0.0 0.2 NUDT11 "DIPP3b, FLJ10628, hDIPP3beta" ENSG00000196368 "Nudix hydrolase 11" Q96G61 X 51490011-51496592 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 23.3;testis: 36.2" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 15.3;Late spermatids: 17.1;Peritubular cells: 20.7;Spermatocytes: 14.6;Spermatogonia: 20.3" "Group enriched" "Detected in many" 4 "glioma: 12.1;prostate cancer: 10.6;testis cancer: 17.4" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "gdT-cell: 1.2" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "HAP1: 69.3;NTERA-2: 42.9" "Low region specificity" "Detected in many" "HPA047027, HPA057684" Approved Approved Cytosol NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 78: Testis - Spermatogenesis" "Cluster 5: NTERA-2 - Transcription" "Cluster 36: Stromal cells - Cell proliferation" Cytosol "HPA047027: AB_2679907, HPA057684: AB_2683501" "unprognostic (2.01e-1)" "unprognostic (2.57e-1)" "unprognostic (8.21e-2)" "unprognostic (1.93e-3)" "unprognostic (6.61e-2)" "unprognostic (1.13e-3)" "unprognostic (5.52e-3)" "unprognostic (1.25e-1)" "unprognostic (2.25e-2)" "unprognostic (2.18e-1)" "unprognostic (8.41e-2)" "unprognostic (1.33e-1)" "unprognostic (7.80e-12)" "unprognostic (4.34e-4)" "unprognostic (1.17e-2)" "unprognostic (2.78e-1)" "unprognostic (3.94e-4)" 1.0 4.6 11.9 0.9 13.7 1.4 2.1 4.5 14.7 4.0 2.1 2.9 1.1 5.1 3.5 1.3 2.0 1.6 0.5 13.4 20.0 0.5 0.1 0.5 0.6 5.6 7.2 8.9 4.9 0.2 4.3 0.0 8.4 9.1 0.8 2.2 0.7 10.4 0.1 1.2 1.0 4.4 5.6 0.3 1.1 36.2 23.3 2.6 0.6 0.5 0.6 1.9 2.4 7.7 0.0 1.0 20.6 0.0 17.5 22.0 0.1 9.8 2.7 0.5 0.5 0.0 0.0 0.0 0.5 11.9 11.4 1.5 69.3 23.9 0.3 0.0 4.7 0.0 0.0 0.0 8.2 0.0 4.6 13.5 9.3 6.2 22.4 3.9 16.4 21.6 0.1 0.0 19.6 0.5 27.6 0.1 42.9 0.0 17.5 0.0 14.4 0.0 4.3 0.0 0.0 13.4 4.2 0.0 4.0 10.2 0.0 0.1 9.6 4.8 22.4 1.4 0.0 9.0 4.5 15.2 3.1 0.0 1.9 0.0 0.0 0.0 1.2 0.0 0.5 0.1 0.3 0.6 0.1 0.1 0.0 0.9 0.0 0.7 0.1 0.0 0.0 0.3 11.9 13.7 4.5 14.7 13.4 20.0 5.6 7.2 8.4 5.6 23.3 7.7 0.4 0.0 0.0 0.3 0.3 15.3 6.4 12.8 12.0 1.6 0.5 3.9 0.6 0.0 1.6 0.0 0.0 0.3 3.5 0.0 0.0 0.2 11.3 0.5 9.0 0.9 0.0 1.3 6.3 1.5 1.0 7.7 0.0 0.3 0.0 3.4 0.4 0.0 0.1 0.0 3.8 0.0 0.0 0.3 3.8 17.1 8.7 0.6 5.4 2.8 0.0 1.4 3.1 4.0 0.6 1.4 0.0 20.7 0.3 10.4 0.0 0.2 0.2 0.2 0.0 3.0 5.3 14.6 20.3 1.6 9.1 0.3 0.8 7.5 0.0 1.3 NUDT2 APAH1 ENSG00000164978 "Nudix hydrolase 2" P50583 9 34329506-34343711 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004684, HPA044903, HPA058623, HPA067639" Uncertain Approved Nucleoplasm NA NA 65000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 35: Non-specific - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm "CAB004684: AB_425306, HPA044903: AB_2679139, HPA058623: AB_2683780, HPA067639: AB_2685877" "unprognostic (2.74e-3)" "unprognostic (2.58e-2)" "unprognostic (3.37e-1)" "unprognostic (2.05e-3)" "unprognostic (3.08e-1)" "unprognostic (2.39e-1)" "unprognostic (1.24e-1)" "unprognostic (6.55e-2)" "unprognostic (7.06e-2)" "unprognostic (3.05e-3)" "unprognostic (1.18e-2)" "unprognostic (2.80e-1)" "unprognostic (2.77e-2)" "unprognostic (6.24e-2)" "unprognostic (1.72e-1)" "unprognostic (1.23e-1)" "unprognostic (1.91e-1)" 21.7 32.0 36.6 10.6 37.9 14.9 26.0 37.4 47.3 26.4 33.6 29.0 16.3 22.3 35.8 26.0 25.2 13.9 28.2 35.8 37.5 23.9 27.0 13.6 17.3 37.5 37.0 34.8 34.5 19.4 30.8 18.1 37.1 26.8 19.0 20.8 21.1 15.6 44.0 25.7 18.6 18.4 38.1 20.2 25.5 16.2 37.4 23.7 7.1 15.0 18.0 28.4 22.6 40.4 59.3 24.2 30.8 10.9 20.7 37.7 22.0 28.1 62.7 31.8 33.0 16.5 27.4 16.7 22.8 35.0 12.2 25.4 28.1 68.7 32.1 61.7 24.8 35.2 44.6 31.4 61.1 28.1 13.9 38.5 45.1 41.4 77.0 43.3 66.2 55.9 10.3 64.7 46.9 36.8 29.1 26.1 19.4 26.8 67.7 36.7 19.2 41.7 31.3 19.2 6.3 24.9 45.1 16.9 27.3 27.4 14.0 29.5 43.2 27.1 24.4 18.0 29.8 14.9 25.7 28.8 33.9 26.0 35.4 20.8 16.2 13.0 14.7 14.6 20.6 22.6 23.9 19.0 20.7 22.2 27.2 23.8 5.8 19.9 15.1 19.1 27.1 15.7 36.6 37.9 37.4 47.3 35.8 37.5 37.5 37.0 37.1 38.1 37.4 40.4 26.3 3.2 4.1 9.1 17.0 28.2 20.5 44.6 14.2 13.6 39.1 53.1 24.9 37.1 20.6 16.5 6.2 39.0 16.7 20.2 88.0 26.7 11.4 20.2 18.5 24.7 22.2 21.0 6.9 40.0 37.8 21.5 13.7 11.5 13.3 21.6 28.5 36.2 36.9 8.4 7.7 34.7 14.2 31.1 23.0 26.8 27.4 20.3 23.2 11.2 25.8 25.9 18.6 12.5 19.0 32.6 26.5 19.2 31.8 18.5 28.7 65.4 25.4 16.5 26.3 21.0 23.9 39.7 19.2 25.0 31.5 18.9 17.8 35.0 30.0 23.6 NUDT3 DIPP ENSG00000272325 "Nudix hydrolase 3" O95989 6 34279679-34392669 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA047027, HPA055953" Uncertain Approved Cytosol NA NA 87000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 80: Striated muscle - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 5: Muller glia cells - Visual perception" Cytosol "HPA047027: AB_2679907, HPA055953: AB_2682984" "unprognostic (2.42e-1)" "prognostic favorable (5.29e-4)" "unprognostic (9.63e-3)" "unprognostic (4.74e-3)" "unprognostic (3.60e-2)" "unprognostic (1.84e-1)" "unprognostic (1.41e-3)" "unprognostic (4.21e-2)" "unprognostic (4.93e-3)" "unprognostic (1.08e-1)" "unprognostic (3.16e-1)" "unprognostic (4.63e-1)" "unprognostic (1.24e-2)" "unprognostic (3.28e-2)" "unprognostic (1.09e-1)" "unprognostic (1.54e-1)" "unprognostic (6.24e-2)" 12.8 12.9 72.7 11.4 65.3 12.0 14.7 41.2 73.1 17.2 33.8 10.4 9.0 13.2 30.1 12.3 17.3 9.2 20.7 64.9 55.9 18.0 12.1 13.3 13.7 60.8 59.6 19.7 10.5 29.9 5.7 10.4 59.0 12.8 10.9 43.1 11.4 17.5 70.8 13.4 9.4 13.0 64.5 16.5 9.8 7.6 73.7 11.4 25.3 51.8 14.9 9.4 7.4 59.5 11.0 8.0 20.9 41.2 13.7 22.9 8.7 7.9 13.2 8.0 5.7 9.7 7.2 37.3 10.5 14.3 5.1 9.2 11.0 21.3 14.7 14.5 15.2 42.9 10.4 20.7 13.0 41.5 21.7 20.8 18.8 9.0 16.8 9.9 23.2 20.1 42.5 14.0 12.6 11.4 28.7 48.1 13.4 32.5 7.3 24.7 17.4 39.2 18.2 22.7 29.3 32.4 17.5 24.4 32.1 6.0 23.6 28.2 25.7 15.6 5.7 14.1 17.4 11.7 28.7 27.9 9.7 40.1 25.4 1.4 3.9 9.2 2.1 4.1 2.4 2.2 2.1 1.9 4.4 3.0 1.9 2.2 2.8 1.4 4.2 2.1 1.6 1.8 72.7 65.3 41.2 73.1 64.9 55.9 60.8 59.6 59.0 64.5 73.7 59.5 36.6 16.0 26.7 0.0 41.4 59.9 72.2 32.4 51.8 117.0 30.5 27.9 47.5 62.9 25.0 42.3 118.9 34.7 28.2 16.1 13.7 19.2 4.1 25.0 38.6 67.0 49.1 40.8 0.0 28.5 32.0 36.4 19.4 37.2 13.9 30.3 109.6 56.1 76.0 169.9 0.0 29.0 22.4 107.1 79.2 8.1 37.6 65.2 53.4 0.0 90.1 137.4 42.2 0.0 0.0 27.9 16.0 63.2 22.8 90.1 25.3 24.4 46.4 126.6 59.2 68.1 35.0 45.6 83.9 58.4 60.2 19.6 26.5 32.8 31.8 64.7 NUDT4 "DIPP2, DIPP2alpha, DIPP2beta, HDCMB47P, KIAA0487" ENSG00000173598 "Nudix hydrolase 4" Q9NZJ9 12 93377883-93408146 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, RNA-binding" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal tubular cells: 361.9;Erythroid cells: 520.6;Muller glia cells: 485.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017593, HPA047027, HPA057684" Approved Approved Cytosol NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 39: CACO-2 - Unknown function" "Cluster 5: Muller glia cells - Visual perception" Cytosol "HPA017593: AB_1854703, HPA047027: AB_2679907, HPA057684: AB_2683501" "unprognostic (1.44e-2)" "unprognostic (2.15e-1)" "unprognostic (4.40e-3)" "unprognostic (4.25e-1)" "unprognostic (3.08e-3)" "unprognostic (1.42e-1)" "unprognostic (8.12e-2)" "unprognostic (9.09e-3)" "unprognostic (1.88e-1)" "unprognostic (1.51e-1)" "unprognostic (2.60e-2)" "unprognostic (1.96e-1)" "prognostic favorable (1.27e-4)" "unprognostic (1.75e-1)" "unprognostic (2.87e-1)" "unprognostic (5.01e-1)" "unprognostic (8.32e-3)" 61.2 71.8 52.1 31.9 60.4 169.2 48.7 37.3 75.5 52.1 48.5 57.4 26.6 30.9 62.5 34.8 44.5 89.8 161.6 61.4 53.1 130.5 45.1 29.0 34.3 48.2 54.5 150.2 62.9 41.7 26.5 60.1 47.5 78.7 62.9 102.0 129.8 38.2 87.2 19.8 35.4 37.9 42.5 25.7 34.6 32.3 48.8 34.8 57.5 115.6 36.3 78.6 26.0 52.7 24.1 20.4 36.4 41.1 132.5 54.3 45.5 66.0 52.4 37.0 27.2 188.4 58.6 33.7 14.0 53.1 24.3 29.5 102.4 33.2 56.5 51.9 21.6 126.9 17.1 99.3 126.8 66.8 29.3 118.5 109.2 38.3 85.0 186.1 212.9 59.7 130.7 46.0 42.9 24.6 61.9 63.7 57.2 59.4 47.7 50.7 32.5 36.5 45.0 171.7 29.1 37.5 53.6 103.3 153.2 58.2 75.2 85.6 81.6 31.6 18.0 47.9 42.5 25.6 34.2 49.4 16.6 51.8 98.3 9.5 2.2 11.3 2.8 2.8 5.1 4.5 4.2 2.9 2.0 3.8 4.4 4.4 1.9 6.0 2.5 3.2 4.2 1.9 52.1 60.4 37.3 75.5 61.4 53.1 48.2 54.5 47.5 42.5 48.8 52.7 44.0 19.2 42.8 8.1 74.8 116.8 123.1 22.5 178.7 66.9 58.3 39.1 243.9 114.4 31.8 62.5 62.6 188.7 49.8 226.9 361.9 21.8 125.6 45.7 38.2 66.4 152.2 520.6 16.6 16.5 32.9 99.2 36.2 60.6 25.4 54.2 41.7 53.4 43.7 42.1 7.5 89.3 12.2 35.1 81.0 26.2 39.1 47.2 106.7 5.6 34.3 485.7 34.0 10.6 1.3 55.1 92.8 46.6 113.9 137.8 68.2 52.8 86.1 44.5 72.3 184.4 204.4 115.7 17.3 119.2 96.7 163.8 80.2 37.3 90.4 178.4 OBSL1 KIAA0657 ENSG00000124006 "Obscurin like cytoskeletal adaptor 1" O75147 2 219550728-219571859 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" Dwarfism "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "ovary: 337.3" "Group enriched" "Detected in many" 8 "Early spermatids: 1140.1;Late spermatids: 1994.5;Spermatocytes: 572.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 7 "basophil: 4.4;plasmacytoid DC: 1.3" "Group enriched" "Detected in many" 11 "dendritic cells: 1.3;granulocytes: 4.4" "Cell line enhanced" "Detected in many" "BEWO: 155.2;SK-BR-3: 150.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036404, HPA036405" Approved Approved Centrosome NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 89: Fibroblasts - ECM organization" "Cluster 28: BEWO - Transcription regulation" "Cluster 31: Spermatids - Spermatogenesis" Centrosome "HPA036404: AB_10670437, HPA036405: AB_2675104" "unprognostic (2.36e-1)" "unprognostic (6.79e-2)" "unprognostic (3.86e-2)" "unprognostic (6.57e-2)" "prognostic unfavorable (6.41e-4)" "unprognostic (7.27e-3)" "unprognostic (2.89e-2)" "unprognostic (9.89e-2)" "unprognostic (4.22e-3)" "unprognostic (1.25e-1)" "unprognostic (4.21e-3)" "unprognostic (7.00e-2)" "unprognostic (3.95e-2)" "unprognostic (3.62e-2)" "unprognostic (1.43e-1)" "unprognostic (3.15e-1)" "unprognostic (2.16e-1)" 52.3 117.5 25.0 9.7 24.3 3.1 53.5 24.4 32.2 74.6 34.4 44.6 9.4 78.0 22.5 17.7 84.6 28.8 90.8 26.1 27.9 110.1 43.9 38.6 9.6 30.3 29.1 337.3 120.6 49.5 74.9 45.8 24.8 63.1 5.4 14.9 62.9 44.2 64.1 38.3 22.5 20.9 25.2 31.7 48.0 40.5 29.7 6.9 148.9 30.2 4.6 41.2 36.7 22.3 34.2 22.7 40.9 85.8 27.7 20.4 155.2 25.3 36.8 31.5 29.0 20.0 52.2 0.2 51.6 34.7 30.5 34.4 31.9 19.0 6.5 0.3 56.2 74.3 23.0 102.1 20.9 1.9 0.3 55.3 15.4 7.3 12.1 56.1 3.4 0.1 31.3 0.7 22.7 84.6 0.1 21.3 97.8 9.7 23.1 37.5 36.3 0.2 57.4 31.9 18.1 61.3 28.6 150.9 59.2 102.8 14.0 63.9 8.6 33.3 35.6 10.6 10.0 0.2 0.2 0.3 19.5 0.2 33.7 4.4 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.2 1.3 0.0 0.0 25.0 24.3 24.4 32.2 26.1 27.9 30.3 29.1 24.8 25.2 29.7 22.3 10.4 9.6 20.4 45.7 1.1 8.4 22.8 11.7 19.9 35.8 27.0 38.7 52.4 27.1 10.0 53.3 2.1 64.7 2.5 1.5 52.8 15.9 1140.1 19.5 33.0 11.4 20.4 0.0 21.1 12.5 69.7 30.1 6.6 21.7 4.5 152.8 11.4 15.4 7.7 42.1 43.3 3.7 6.1 1.0 3.9 1994.5 77.0 3.4 14.2 9.4 0.7 87.0 0.0 23.1 3.1 7.6 2.0 74.1 0.1 8.8 7.1 20.3 7.8 11.6 13.1 29.9 27.0 572.7 57.0 4.3 6.7 86.5 1.4 114.0 3.3 10.2 OGA "MEA5, MGEA5, NCOAT" ENSG00000198408 O-GlcNAcase O60502 10 101784443-101818465 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction" "Glycosidase, Hydrolase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Collecting duct cells: 86.5;dendritic cells: 89.3;Glandular and luminal cells: 83.7;Granulosa cells: 69.4;Pancreatic endocrine cells: 82.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036141, HPA076501" Approved Supported Cytosol NA NA "Cluster 6: Non-specific - Transcription" "Cluster 6: Brain - Smell perception" "Cluster 30: Epithelial cell lines - Translation" "Cluster 7: Non-specific - Mitochondria" Cytosol "HPA036141: AB_10672079, HPA076501: AB_2686802" "unprognostic (4.34e-1)" "unprognostic (1.57e-1)" "prognostic unfavorable (8.69e-5)" "unprognostic (4.63e-1)" "unprognostic (2.06e-1)" "unprognostic (2.57e-2)" "unprognostic (2.65e-1)" "unprognostic (1.79e-2)" "unprognostic (2.44e-1)" "unprognostic (1.21e-3)" "unprognostic (6.00e-2)" "unprognostic (7.81e-2)" "unprognostic (1.68e-1)" "unprognostic (3.01e-1)" "unprognostic (3.21e-2)" "unprognostic (1.90e-1)" "unprognostic (9.23e-3)" 65.3 34.1 77.3 46.7 80.3 89.0 59.2 99.3 82.8 62.2 54.3 64.8 28.1 50.0 55.5 57.4 52.9 29.8 60.7 82.2 74.0 45.6 46.0 52.9 69.8 66.8 70.3 66.8 42.9 60.6 44.9 41.0 67.7 52.7 40.7 99.8 50.5 38.9 56.6 72.7 62.8 35.4 68.6 74.4 46.4 38.6 84.3 67.6 51.7 29.5 64.8 57.0 58.6 77.6 89.8 44.7 63.7 124.6 40.0 96.6 44.4 61.7 61.8 28.1 48.0 33.1 56.0 59.6 43.7 73.7 48.2 62.9 60.3 77.5 59.2 87.9 41.2 59.6 65.0 26.0 43.1 44.4 32.3 93.9 85.1 48.1 113.7 80.0 53.0 53.1 42.8 107.3 48.3 45.6 47.2 46.1 35.4 19.4 44.8 64.8 70.5 44.0 47.2 80.0 27.7 48.8 55.2 29.4 78.2 58.0 77.9 47.7 80.9 43.0 41.6 63.0 71.6 53.1 91.0 47.2 54.0 74.6 24.0 14.4 2.1 7.2 6.4 2.0 5.1 6.6 4.5 5.8 1.3 7.5 6.1 5.2 14.1 6.6 6.3 3.3 4.6 1.5 77.3 80.3 99.3 82.8 82.2 74.0 66.8 70.3 67.7 68.6 84.3 77.6 66.3 0.0 0.0 0.0 40.2 0.0 0.0 0.0 0.0 0.0 66.5 47.0 0.0 0.0 0.0 86.5 0.0 41.9 89.3 0.0 13.7 38.0 0.0 61.6 68.3 18.1 0.0 0.0 0.0 40.9 34.3 20.3 0.0 83.7 0.0 69.4 0.0 0.0 39.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 23.5 0.0 0.0 48.6 0.0 0.0 0.0 0.0 82.4 0.0 0.0 44.3 0.0 0.0 34.0 0.0 0.0 0.0 0.0 28.3 0.0 0.0 0.0 0.0 50.9 34.6 44.8 0.0 0.0 OTUD5 "DKFZp761A052, DUBA" ENSG00000068308 "OTU deubiquitinase 5" Q96G74 X 48922024-48958386 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Group enriched" "Detected in all" 10 "U-266/70: 1503.3;U-266/84: 407.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017375 Approved Approved "Nucleoplasm,Nucleoli fibrillar center,Cytosol" NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 29: U-266 - Adaptive immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Cytosol "Nucleoplasm, Nucleoli fibrillar center" "HPA017375: AB_1854844" "unprognostic (9.73e-2)" "prognostic favorable (9.57e-4)" "unprognostic (2.67e-2)" "unprognostic (7.25e-2)" "unprognostic (1.08e-1)" "unprognostic (6.65e-2)" "unprognostic (2.33e-3)" "prognostic favorable (1.48e-4)" "unprognostic (1.11e-1)" "unprognostic (1.14e-1)" "prognostic favorable (8.20e-4)" "unprognostic (1.32e-1)" "unprognostic (3.60e-1)" "unprognostic (1.19e-1)" "unprognostic (1.10e-1)" "unprognostic (4.88e-2)" "unprognostic (5.05e-3)" 37.7 44.8 42.9 36.9 44.9 56.7 36.6 39.2 45.5 40.6 33.6 45.8 39.6 43.0 29.9 37.5 41.4 24.7 29.9 44.8 46.1 41.1 39.5 39.6 43.4 44.2 42.8 46.8 37.7 35.6 46.1 26.4 46.0 43.1 21.7 30.2 36.3 32.0 39.7 44.6 47.3 27.0 38.3 60.7 37.5 24.2 44.9 47.0 42.3 25.2 35.8 39.9 36.7 43.9 53.0 77.8 36.0 88.9 59.2 52.3 41.4 45.7 52.9 55.9 59.8 39.7 57.3 58.9 29.2 56.8 49.1 63.3 54.2 45.7 51.7 69.1 65.0 44.5 79.4 45.0 49.3 43.4 48.7 58.1 41.2 58.2 39.5 61.4 44.7 47.8 56.9 90.7 40.0 52.3 67.7 89.2 64.9 19.5 60.4 53.0 52.5 77.4 38.9 46.4 34.7 60.7 60.2 38.7 61.7 82.7 51.6 39.2 64.2 36.5 46.2 97.2 38.1 1503.3 407.1 56.5 56.3 58.9 25.7 5.5 3.3 7.6 6.6 5.2 5.6 8.6 5.1 5.7 4.8 5.3 4.8 7.1 8.5 20.3 5.1 6.2 7.3 3.6 42.9 44.9 39.2 45.5 44.8 46.1 44.2 42.8 46.0 38.3 44.9 43.9 21.3 9.6 22.3 17.3 33.3 22.2 21.2 13.7 13.1 35.5 23.7 19.7 11.5 15.7 16.3 27.6 27.1 13.3 38.2 28.4 9.8 13.6 1.9 24.5 23.2 19.6 48.2 32.6 15.5 18.3 16.3 18.4 21.4 33.1 7.0 28.5 22.1 24.3 16.7 28.6 15.7 28.5 10.2 22.9 33.9 2.9 20.8 25.7 26.6 15.9 22.6 18.0 30.9 14.1 14.1 21.5 19.0 23.7 38.1 27.5 28.1 21.7 21.6 27.9 13.1 19.9 20.1 10.4 12.6 15.9 25.6 30.8 33.3 28.6 20.1 27.4 OXSR1 "KIAA1101, OSR1" ENSG00000172939 "Oxidative stress responsive kinase 1" O95747 3 38165089-38255484 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008237, CAB017181" Supported Enhanced Cytosol NA NA 300000 "Cluster 38: Basophils - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 41: Macrophages - Immune response" Cytosol "CAB017181: , HPA008237: AB_1079540" "unprognostic (2.16e-1)" "unprognostic (2.36e-2)" "unprognostic (1.79e-2)" "unprognostic (4.55e-3)" "unprognostic (9.89e-2)" "unprognostic (1.97e-2)" "unprognostic (3.53e-3)" "unprognostic (4.05e-2)" "unprognostic (4.44e-1)" "unprognostic (6.06e-2)" "unprognostic (3.95e-3)" "unprognostic (1.88e-2)" "unprognostic (1.87e-3)" "unprognostic (1.56e-1)" "unprognostic (3.14e-2)" "unprognostic (1.71e-1)" "unprognostic (6.99e-3)" 18.4 17.2 9.7 15.7 10.0 33.8 15.6 13.6 12.5 17.8 13.0 18.3 15.2 14.8 15.6 34.1 12.8 15.1 16.9 9.9 10.8 21.5 18.6 15.5 18.5 11.0 11.0 16.1 12.1 26.3 11.5 16.5 11.1 16.5 19.7 13.0 15.2 16.3 36.7 19.5 15.7 17.6 10.2 15.0 16.8 14.1 11.0 25.1 14.8 35.4 23.4 26.7 21.1 11.2 48.5 21.9 42.5 29.8 29.0 33.3 48.2 41.9 57.1 59.2 63.8 28.3 30.8 53.4 20.8 50.5 25.4 29.4 57.8 43.1 77.5 57.6 24.5 58.6 46.1 31.1 34.6 36.6 34.2 26.6 49.6 54.8 87.8 55.7 37.5 67.7 45.2 29.9 102.7 13.7 71.1 26.4 44.8 31.2 26.1 24.2 35.7 41.4 36.4 36.4 22.0 34.0 45.9 114.2 29.0 46.3 37.7 23.7 34.4 37.0 36.6 56.8 63.0 22.7 29.0 38.7 50.7 44.6 75.3 6.8 1.6 3.9 1.8 2.8 1.9 1.0 2.2 1.7 2.6 1.2 1.7 2.1 3.2 3.1 2.5 1.4 2.8 0.9 9.7 10.0 13.6 12.5 9.9 10.8 11.0 11.0 11.1 10.2 11.0 11.2 19.0 12.8 25.8 46.7 27.3 44.1 35.5 25.3 26.7 13.3 19.4 16.5 32.6 4.3 27.6 27.6 20.9 12.1 27.4 44.0 19.6 28.4 3.9 39.9 32.1 19.0 24.1 29.7 59.6 14.5 21.0 18.4 90.7 91.2 15.8 24.9 14.6 20.5 14.9 21.9 51.9 24.5 10.2 29.8 79.0 2.3 9.6 58.0 7.2 29.0 35.2 8.0 18.6 44.7 42.8 46.5 29.4 12.8 19.5 56.5 27.0 22.5 16.1 7.0 13.1 23.7 22.6 15.1 18.5 41.9 51.9 33.0 29.6 19.6 21.6 115.3 P4HB "DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PO4DB, PO4HB, PROHB" ENSG00000185624 "Prolyl 4-hydroxylase subunit beta" P07237 17 81843159-81860856 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Chaperone, Isomerase" "Craniosynostosis, Disease variant, Osteogenesis imperfecta" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 1856.8;pancreas: 2446.9" "Cell type enhanced" "Detected in all" "Exocrine glandular cells: 1077.9;Extravillous trophoblasts: 1349.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB012463, HPA018884" Enhanced Supported "Endoplasmic reticulum" "Intracellular and membrane" No No 110000000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 29: Non-specific - Vesicular transport" "Cluster 43: THP-1 - Innate immune response" "Cluster 55: Plasma cells - Humoral immune response" "Endoplasmic reticulum" "CAB012463: , HPA018884: AB_1854896" "unprognostic (9.47e-3)" "unprognostic (1.09e-2)" "unprognostic (2.99e-2)" "unprognostic (7.14e-3)" "unprognostic (7.75e-3)" "unprognostic (1.05e-2)" "unprognostic (1.30e-1)" "unprognostic (5.26e-2)" "unprognostic (1.22e-1)" "unprognostic (4.73e-3)" "unprognostic (1.43e-1)" "unprognostic (3.93e-2)" "prognostic unfavorable (2.30e-11)" "unprognostic (1.18e-1)" "unprognostic (1.04e-2)" "unprognostic (4.99e-3)" "unprognostic (3.19e-3)" 266.5 507.8 34.6 209.8 35.7 517.1 225.5 39.1 35.7 272.0 59.6 258.4 640.2 206.5 133.0 618.7 183.4 202.0 318.4 31.7 50.2 270.7 1856.8 301.3 104.0 48.9 37.1 187.8 2446.9 144.3 330.0 334.3 40.8 335.8 173.6 23.3 948.1 184.2 328.5 370.4 554.7 179.8 39.8 428.6 539.2 68.8 58.7 89.3 244.8 150.8 137.9 233.7 322.9 43.7 690.3 580.7 236.8 687.5 813.4 726.7 593.6 1038.5 1081.1 741.9 934.5 550.4 576.9 264.4 501.8 1120.2 407.5 464.1 248.8 647.4 254.1 145.8 320.5 355.2 362.9 953.6 1010.8 1146.4 613.4 618.8 494.8 478.2 596.7 843.0 1250.1 182.1 273.6 978.2 559.5 566.4 260.5 723.2 157.7 791.0 463.8 261.8 342.5 614.0 453.2 492.8 248.7 301.1 586.1 1693.1 808.1 289.6 855.3 1601.2 644.1 980.5 503.1 574.3 586.6 743.5 407.9 204.8 1372.0 591.3 825.4 198.3 268.1 163.0 202.6 154.4 209.8 83.9 138.9 165.7 174.7 68.1 74.9 114.6 72.9 157.0 115.3 311.5 105.6 372.4 34.6 35.7 39.1 35.7 31.7 50.2 48.9 37.1 40.8 39.8 58.7 43.7 122.3 102.5 162.1 23.2 151.4 120.1 163.6 371.0 140.6 59.2 283.0 170.8 24.1 247.4 211.7 112.2 33.3 790.2 208.9 420.7 41.1 671.9 43.5 78.4 196.8 153.9 199.9 140.9 15.3 1077.9 1349.1 272.5 388.9 209.1 99.1 210.4 190.2 840.7 435.9 62.2 16.2 610.9 189.2 186.9 125.5 64.9 141.4 180.3 136.9 20.6 263.3 122.7 230.7 13.6 19.6 575.2 465.6 112.1 664.3 310.6 914.2 105.0 91.3 54.3 157.8 103.4 226.7 83.4 94.1 302.3 144.6 1001.2 138.8 378.4 475.4 220.8 PAK1 ENSG00000149269 "P21 (RAC1) activated kinase 1" Q13153 11 77322017-77474635 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Exocytosis" "Allosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Excitatory neurons: 219.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Group enriched" "Detected in all" 9 "classical monocyte: 182.2;eosinophil: 292.7;intermediate monocyte: 177.7;myeloid DC: 264.3;neutrophil: 431.8;non-classical monocyte: 202.6" "Group enriched" "Detected in all" 11 "dendritic cells: 264.3;granulocytes: 431.8;monocytes: 202.6" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003565, CAB005312" Enhanced Supported Supported "Plasma membrane,Cytosol" NA NA 560000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 29: U-266 - Adaptive immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane, Cytosol" "CAB005312: AB_2160720, HPA003565: AB_1854935" "unprognostic (1.15e-2)" "unprognostic (3.23e-2)" "prognostic favorable (5.87e-4)" "unprognostic (1.30e-1)" "prognostic unfavorable (1.15e-4)" "unprognostic (6.62e-2)" "unprognostic (8.19e-3)" "unprognostic (4.84e-2)" "unprognostic (1.05e-1)" "unprognostic (1.22e-3)" "unprognostic (1.86e-2)" "unprognostic (2.76e-1)" "unprognostic (1.02e-1)" "unprognostic (6.91e-2)" "unprognostic (1.57e-1)" "unprognostic (4.00e-3)" "unprognostic (1.52e-2)" 12.7 13.4 32.4 33.9 44.5 59.0 18.2 13.9 57.7 21.1 0.0 43.2 43.1 20.9 29.8 21.4 21.9 30.9 9.4 58.3 8.0 26.1 14.5 16.8 20.4 19.2 12.2 21.1 17.5 20.5 20.7 14.7 19.4 19.1 46.5 25.1 19.9 19.7 87.0 16.2 45.7 27.0 0.9 29.3 41.2 25.7 17.1 29.1 40.6 18.8 23.1 27.7 20.7 30.0 39.9 26.7 56.7 25.5 22.8 37.6 45.9 44.6 32.1 42.0 48.7 38.7 52.8 36.3 16.0 39.4 54.4 20.2 40.2 47.8 65.5 41.4 32.6 38.2 17.6 2.3 15.3 64.3 53.5 28.2 28.8 49.2 73.1 36.6 10.1 41.3 25.5 61.2 77.6 2.9 42.3 30.2 84.5 166.2 22.5 62.6 72.3 1.4 10.6 32.9 24.6 23.9 23.6 9.7 19.5 55.0 45.4 29.0 0.9 27.3 47.5 148.9 37.9 165.7 92.4 23.4 23.0 42.5 30.6 2.5 182.2 292.7 11.2 177.7 9.4 16.8 8.4 10.7 264.3 12.9 7.4 14.5 431.8 28.4 202.6 22.9 7.3 92.3 32.4 44.5 13.9 57.7 58.3 8.0 19.2 12.2 19.4 0.9 17.1 30.0 3.1 3.2 20.5 24.2 23.9 11.9 33.3 28.2 23.9 51.6 25.1 19.7 6.2 35.8 30.8 25.8 8.4 25.4 10.2 78.6 45.0 32.4 38.8 37.3 13.5 3.2 37.8 30.5 219.1 56.3 53.5 24.0 45.9 39.7 132.2 35.2 3.6 11.4 49.8 1.7 118.5 50.8 28.5 59.6 152.9 28.3 14.3 80.0 30.2 54.4 121.7 14.9 10.3 53.3 70.7 50.9 57.9 13.2 28.6 28.7 47.9 55.7 39.0 6.4 13.1 13.8 25.2 50.4 53.8 23.6 10.4 95.0 19.3 10.3 52.8 33.2 PAK2 "PAK65, PAKgamma" ENSG00000180370 "P21 (RAC1) activated kinase 2" Q13177 3 196739857-196832647 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Growth regulation, Host-virus interaction" "Allosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB007794 Approved Approved Nucleoplasm,Vesicles NA NA 1700000 "Cluster 5: Granulocytes - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "Nucleoplasm, Vesicles" "CAB007794: AB_562363" "unprognostic (1.03e-2)" "unprognostic (6.34e-2)" "unprognostic (2.52e-1)" "unprognostic (2.50e-2)" "unprognostic (1.32e-1)" "unprognostic (1.80e-1)" "unprognostic (5.18e-3)" "unprognostic (1.85e-2)" "unprognostic (7.97e-2)" "unprognostic (1.09e-1)" "prognostic unfavorable (3.36e-4)" "prognostic unfavorable (9.58e-4)" "unprognostic (1.30e-3)" "unprognostic (4.57e-2)" "unprognostic (1.25e-2)" "unprognostic (1.70e-2)" "unprognostic (3.39e-1)" 31.8 18.1 21.2 34.6 24.9 28.1 19.5 25.0 21.7 21.1 19.8 25.6 23.0 21.9 16.0 26.5 20.5 23.8 24.0 19.5 24.6 22.1 33.8 26.3 40.9 26.7 23.4 19.8 18.5 32.6 8.4 33.3 27.7 20.1 26.6 17.4 14.5 18.9 28.3 16.6 22.5 27.0 24.8 43.5 20.9 15.1 23.0 45.1 19.7 25.9 39.4 34.1 16.0 34.1 140.7 49.1 67.6 49.8 47.1 61.9 100.0 69.1 57.0 73.7 66.8 117.5 70.1 89.4 192.7 70.8 75.1 70.2 72.5 66.2 113.6 39.9 35.2 132.2 52.1 92.5 95.0 130.2 122.0 49.6 53.1 66.2 139.2 78.1 74.3 97.3 65.0 107.5 72.9 146.7 124.8 67.2 40.5 74.7 73.4 112.4 38.6 80.9 64.8 96.7 39.6 44.7 92.8 64.7 52.7 51.9 227.0 92.6 76.9 60.9 33.6 64.3 103.1 72.5 138.9 216.4 50.4 127.6 59.1 37.3 20.0 48.0 10.9 23.2 14.7 11.2 12.7 12.6 25.4 11.3 9.1 10.9 47.6 12.2 21.2 9.3 20.7 14.9 21.2 24.9 25.0 21.7 19.5 24.6 26.7 23.4 27.7 24.8 23.0 34.1 164.9 80.1 40.2 37.9 142.8 97.4 89.2 41.8 96.2 42.6 59.7 47.5 59.3 62.9 45.1 82.8 52.1 50.3 135.1 69.6 33.2 71.5 57.1 107.9 112.6 104.0 44.9 72.3 32.2 59.0 101.4 68.9 58.1 96.1 148.8 70.9 66.0 138.6 104.3 55.5 38.9 46.4 57.0 160.5 115.9 75.5 60.9 169.6 33.8 46.9 183.2 63.7 140.1 37.2 61.3 100.4 52.1 45.5 100.0 149.4 58.2 85.2 76.4 45.0 39.5 86.0 75.9 24.5 43.0 103.2 86.2 34.9 139.1 96.3 51.0 124.1 PAK3 "bPAK, hPAK3, MRX30, MRX47" ENSG00000077264 "P21 (RAC1) activated kinase 3" O75914 X 110944285-111227361 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Allosteric enzyme, Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 31.9;pancreas: 42.7;pituitary gland: 13.7" "Cell type enhanced" "Detected in many" "Bipolar cells: 104.1;Excitatory neurons: 364.0;Inhibitory neurons: 323.5;Oligodendrocyte precursor cells: 165.9;Peritubular cells: 81.3" "Cancer enhanced" "Detected in some" "pancreatic cancer: 1.7" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 5 "MAIT T-cell: 1.0" "Lineage enriched" "Detected in single" 5 "T-cells: 1.0" "Cell line enhanced" "Detected in some" "EFO-21: 10.8;HAP1: 9.9;HDLM-2: 12.4;NTERA-2: 9.7;SCLC-21H: 12.4;SH-SY5Y: 7.7;U-2197: 7.6;U-251 MG: 13.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA044791, HPA060219" Approved Approved Vesicles NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 22: Non-specific - Unknown function" "Cluster 44: HDLM-2 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles "HPA044791: , HPA060219: AB_2684223" "unprognostic (1.80e-2)" "unprognostic (1.54e-1)" "unprognostic (1.80e-2)" "unprognostic (3.27e-4)" "unprognostic (2.46e-1)" "unprognostic (5.63e-3)" "unprognostic (7.29e-2)" "unprognostic (3.23e-2)" "unprognostic (1.27e-2)" "unprognostic (3.01e-1)" "unprognostic (6.80e-3)" "unprognostic (1.66e-1)" "unprognostic (1.89e-4)" "unprognostic (5.71e-3)" "unprognostic (6.81e-2)" "unprognostic (1.06e-1)" "unprognostic (3.30e-2)" 1.0 5.2 16.9 1.6 16.2 0.1 5.2 0.0 17.6 2.3 0.0 0.7 0.2 5.4 5.8 0.7 2.5 1.6 0.3 17.8 31.9 0.7 0.2 0.9 1.7 1.6 0.0 6.2 42.7 0.1 13.7 0.6 6.0 3.4 0.7 7.0 2.2 4.8 1.6 1.3 0.5 4.7 0.4 2.0 2.0 2.6 13.2 0.6 6.2 0.4 0.8 0.9 0.7 2.8 0.0 0.7 1.4 0.0 0.0 0.0 0.0 0.3 0.4 1.1 0.0 0.0 0.0 0.0 10.8 1.2 1.6 0.0 9.9 0.6 1.3 12.4 0.4 0.0 1.3 0.0 0.0 0.0 0.4 0.3 0.0 0.1 2.2 5.7 0.0 0.2 0.0 0.5 0.0 0.0 0.1 0.2 9.7 0.0 2.2 0.1 4.3 0.0 0.8 0.0 12.4 7.7 0.0 0.4 0.0 6.6 0.0 0.0 0.0 0.7 4.7 7.6 13.6 0.1 0.1 0.1 1.3 0.0 0.1 0.2 0.0 0.0 0.0 0.0 1.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 16.9 16.2 0.0 17.6 17.8 31.9 1.6 0.0 6.0 0.4 13.2 2.8 0.9 3.2 1.1 16.0 0.6 0.3 13.3 0.2 0.0 104.1 6.9 10.4 1.0 20.0 0.7 0.0 0.0 0.3 0.2 0.2 0.0 4.7 4.4 1.0 10.8 2.3 3.6 0.0 364.0 13.1 0.4 10.3 10.2 1.7 1.3 21.9 1.4 0.2 0.2 6.7 323.5 0.3 0.0 0.3 5.7 7.0 34.2 1.1 0.0 17.8 0.7 27.5 1.0 165.9 12.0 5.3 0.0 81.3 1.0 1.7 0.0 0.6 0.0 6.0 0.0 1.6 7.8 1.4 1.4 0.3 1.1 6.7 2.4 29.2 0.3 0.9 PAK4 ENSG00000130669 "P21 (RAC1) activated kinase 4" O96013 19 39125770-39182816 "Enzymes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "A549: 154.7;MCF7: 172.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025747, CAB044670, HPA070175, HPA072220" Uncertain Supported "Plasma membrane,Cell Junctions" NA Yes "Cluster 26: Non-specific - Mitochondria" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 17: Intestinal endocrine cells - Hormone signaling" "Plasma membrane, Cell Junctions" "CAB025747: , CAB044670: AB_1854940, HPA070175: AB_2686232, HPA072220: AB_2686497" "unprognostic (1.71e-1)" "unprognostic (2.84e-1)" "unprognostic (5.86e-2)" "unprognostic (2.84e-2)" "unprognostic (1.93e-1)" "unprognostic (8.51e-2)" "unprognostic (3.56e-3)" "unprognostic (1.13e-3)" "unprognostic (3.90e-2)" "unprognostic (4.04e-2)" "unprognostic (7.29e-2)" "prognostic unfavorable (9.85e-4)" "prognostic favorable (5.29e-5)" "unprognostic (2.39e-1)" "unprognostic (7.05e-2)" "unprognostic (2.02e-1)" "unprognostic (4.85e-2)" 11.6 20.0 16.7 8.1 18.2 5.3 22.1 14.2 18.4 27.2 14.0 30.2 27.4 20.6 9.4 43.9 23.4 7.5 15.5 13.9 13.4 37.2 26.2 39.6 4.5 17.1 17.2 24.2 31.8 16.2 30.5 16.3 15.8 40.7 8.0 5.8 42.4 11.0 14.0 40.4 25.1 5.7 12.0 13.8 25.3 35.0 15.7 5.4 29.3 4.3 5.4 20.2 30.4 17.0 62.8 154.7 22.7 34.8 7.1 7.5 68.1 29.3 11.7 19.3 19.4 102.1 51.9 14.3 43.3 18.7 25.2 22.7 12.6 23.2 7.2 38.0 35.4 16.9 27.5 50.4 11.3 17.5 23.6 9.0 10.2 18.1 12.9 12.6 25.5 21.4 34.3 11.0 11.8 172.7 18.6 18.9 41.4 55.2 36.7 18.5 17.9 10.9 19.0 67.9 72.2 49.9 29.8 130.6 33.6 11.7 58.1 28.4 42.8 32.6 55.6 37.8 53.0 12.3 12.9 11.9 39.9 10.3 39.9 0.3 0.7 1.2 0.6 0.3 0.8 0.5 0.7 1.1 0.9 0.6 0.5 0.5 0.5 0.9 0.6 0.8 0.9 0.7 16.7 18.2 14.2 18.4 13.9 13.4 17.1 17.2 15.8 12.0 15.7 17.0 5.1 0.0 1.5 9.4 3.9 14.4 15.9 13.8 9.6 18.8 34.2 21.7 2.0 20.0 9.1 18.4 25.0 42.6 4.4 47.5 31.3 20.5 4.1 19.5 8.5 15.0 44.9 5.0 3.9 19.7 67.4 8.8 23.9 23.3 5.7 21.6 10.0 13.3 9.6 21.9 4.2 33.8 28.5 5.3 4.1 6.4 11.8 3.6 7.2 8.4 11.2 13.6 8.2 9.5 13.5 21.8 44.2 10.5 5.8 21.7 39.5 14.4 13.7 13.4 0.0 8.5 7.5 10.4 24.0 20.1 18.8 65.4 6.0 22.3 33.9 24.3 PAK5 "KIAA1264, PAK7" ENSG00000101349 "P21 (RAC1) activated kinase 5" Q9P286 20 9537370-9839076 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "brain: 12.0;retina: 4.7" "Group enriched" "Detected in some" 4 "Breast myoepithelial cells: 6.5;Glandular and luminal cells: 2.0;Granulosa cells: 5.8" "Cancer enhanced" "Detected in single" "glioma: 0.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "SCLC-21H: 4.6;SH-SY5Y: 1.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA020444 Approved Approved Nucleoplasm NA NA "Cluster 6: Brain - Smell perception" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "HPA020444: AB_1854947" "unprognostic (5.14e-5)" "unprognostic (3.35e-1)" "unprognostic (1.05e-1)" "unprognostic (8.63e-2)" "unprognostic (3.21e-1)" "unprognostic (3.04e-1)" "unprognostic (2.25e-4)" "unprognostic (3.76e-1)" "unprognostic (2.56e-2)" "unprognostic (3.83e-1)" "unprognostic (3.35e-2)" "unprognostic (6.04e-2)" "unprognostic (4.58e-1)" 0.0 1.9 3.6 0.0 4.8 0.0 0.4 12.0 8.4 0.1 0.0 0.0 0.0 0.2 0.6 0.2 0.0 1.2 0.0 5.5 0.7 0.2 0.7 0.0 0.0 0.3 1.4 0.0 1.3 0.0 1.2 0.0 0.4 0.4 0.0 4.7 0.3 0.4 0.0 0.4 0.0 0.0 0.2 0.0 0.3 0.2 2.1 0.4 0.0 0.0 0.0 0.0 0.0 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.6 1.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 4.8 12.0 8.4 5.5 0.7 0.3 1.4 0.4 0.2 2.1 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 6.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.0 0.0 5.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 PAK6 PAK5 ENSG00000137843 "P21 (RAC1) activated kinase 6" Q9NQU5 15 40217428-40277487 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 25.6;skin 1: 28.2" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 52.7;NK-cells: 16.5;Suprabasal keratinocytes: 19.0" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "CACO-2: 26.5;HaCaT: 32.2;hTCEpi: 19.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA031124 Approved Approved "Nucleoplasm,Nucleoli fibrillar center,Cell Junctions" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 27: Brain & Skin - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 47: Cytotrophoblasts - Unknown function" "Nucleoplasm, Nucleoli fibrillar center" "Cell Junctions" "HPA031124: AB_10601044" "unprognostic (1.85e-3)" "unprognostic (2.15e-1)" "unprognostic (3.33e-3)" "unprognostic (7.79e-3)" "unprognostic (7.08e-3)" "unprognostic (9.57e-2)" "unprognostic (2.71e-1)" "unprognostic (7.73e-2)" "unprognostic (1.34e-2)" "unprognostic (7.13e-3)" "unprognostic (4.04e-2)" "unprognostic (8.87e-3)" "unprognostic (1.72e-1)" "unprognostic (1.79e-1)" "unprognostic (7.37e-3)" "unprognostic (3.34e-2)" 0.2 8.2 11.6 0.4 15.9 0.9 2.1 8.5 16.6 4.5 0.0 1.3 1.5 0.9 1.0 25.6 4.3 1.1 8.3 17.6 3.0 4.7 0.3 2.5 0.9 1.4 1.1 0.6 8.0 8.0 12.1 7.6 1.9 4.4 1.1 0.8 6.1 3.8 4.5 28.2 1.5 0.3 1.8 0.9 3.9 17.7 3.0 0.5 7.5 1.3 1.9 3.5 9.4 5.4 3.9 0.0 0.2 0.0 0.0 0.0 6.0 0.0 0.2 0.7 0.7 26.5 2.9 0.1 3.6 0.0 1.3 32.2 4.5 6.9 0.3 0.2 1.0 0.0 3.0 0.2 0.0 0.1 0.3 0.0 19.4 0.3 4.5 0.2 0.0 5.5 1.8 0.3 0.0 4.5 0.0 0.5 0.5 3.9 2.9 0.2 0.2 2.9 1.5 8.4 7.3 2.0 2.6 10.9 0.3 1.7 1.7 10.3 0.0 0.3 0.6 0.0 0.3 0.1 0.3 0.1 0.7 0.6 0.2 1.2 0.1 1.2 2.3 0.1 0.8 0.6 0.1 1.9 0.3 0.1 0.1 0.4 0.5 0.9 0.1 0.1 0.0 0.6 11.6 15.9 8.5 16.6 17.6 3.0 1.4 1.1 1.9 1.8 3.0 5.4 0.0 0.0 4.2 0.7 0.3 9.8 9.6 4.8 8.6 3.5 2.8 2.9 0.0 4.3 5.4 5.5 0.0 52.7 2.1 0.3 13.7 4.4 8.6 3.3 0.4 0.3 4.9 0.0 8.9 4.3 3.0 0.7 0.5 5.1 0.0 0.7 0.0 0.0 4.1 0.0 7.3 1.1 2.0 0.6 0.9 5.8 1.8 0.3 1.8 1.0 0.0 1.3 16.5 0.5 0.3 2.5 1.0 1.9 0.1 5.2 0.2 0.2 3.9 0.2 0.0 0.3 0.4 1.9 3.3 13.9 19.0 9.0 1.0 0.8 2.0 11.3 PAM "PAL, PHM" ENSG00000145730 "Peptidylglycine alpha-amidating monooxygenase" P19021 5 102753981-103031105 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Lyase, Monooxygenase, Multifunctional enzyme, Oxidoreductase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 1560.4" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 1406.5;Enteroendocrine cells: 321.4;Inhibitory neurons: 487.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "ASC diff: 529.9;fHDF/TERT166: 714.5;hTERT-RPE1: 562.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB026119, HPA042260" Enhanced Approved "Golgi apparatus,Cytosol" "Secreted in other tissues" NA NA 98000000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 54: Cardiomyocytes - Muscle contraction" "Golgi apparatus, Cytosol" "CAB026119: , HPA042260: AB_2677919" "unprognostic (4.30e-3)" "unprognostic (1.60e-2)" "unprognostic (1.12e-1)" "prognostic favorable (1.63e-4)" "unprognostic (4.23e-2)" "unprognostic (6.30e-2)" "prognostic unfavorable (6.20e-4)" "unprognostic (7.58e-2)" "unprognostic (6.62e-2)" "unprognostic (2.71e-1)" "unprognostic (9.91e-2)" "unprognostic (3.18e-1)" "unprognostic (1.86e-2)" "unprognostic (1.08e-1)" "unprognostic (9.79e-2)" "unprognostic (5.51e-2)" "unprognostic (8.80e-3)" 119.3 202.5 71.6 34.6 81.4 10.1 99.0 50.7 82.5 595.0 96.2 125.1 52.6 140.9 678.2 69.4 87.6 97.3 1560.4 75.2 179.9 116.0 20.1 88.3 27.7 86.5 99.8 136.4 104.4 257.8 137.0 60.0 170.9 91.6 80.4 37.6 205.4 236.5 155.3 66.9 52.1 157.9 55.7 52.5 131.6 22.4 106.0 17.9 95.1 159.4 30.5 103.3 116.1 50.0 111.3 16.3 195.9 87.2 529.9 314.8 78.0 307.6 457.0 89.1 268.9 53.5 143.2 0.1 65.0 714.5 125.7 36.8 11.0 135.3 244.0 13.5 44.7 22.9 60.0 17.7 80.3 7.4 23.9 173.4 57.3 65.6 49.2 562.6 186.8 8.9 0.9 15.0 255.6 22.9 0.1 3.2 35.3 19.7 59.3 8.5 108.9 62.4 346.1 13.0 92.3 63.9 131.2 8.3 83.3 114.0 34.0 7.3 144.9 280.8 72.4 133.3 93.4 33.1 8.6 0.4 322.3 30.8 247.6 4.2 8.0 0.2 20.7 1.5 14.9 0.8 12.3 15.6 3.1 0.4 4.1 6.8 16.6 26.3 3.4 1.6 19.9 10.8 71.6 81.4 50.7 82.5 75.2 179.9 86.5 99.8 170.9 55.7 106.0 50.0 45.7 54.5 39.3 47.0 3.9 28.2 12.0 26.1 12.0 19.1 27.5 12.1 1406.5 0.0 30.4 60.7 2.1 1.6 12.6 13.7 7.9 12.6 8.8 47.6 48.6 63.5 321.4 3.4 229.2 21.5 40.6 220.4 26.0 83.0 9.5 68.3 74.6 3.5 5.9 8.4 487.7 13.8 18.3 10.3 48.3 8.1 60.3 9.3 37.4 192.0 9.5 11.6 22.6 154.8 9.3 30.6 6.3 58.6 12.1 26.4 4.8 43.8 19.2 3.8 19.7 36.4 44.9 2.6 5.6 8.0 23.7 6.7 16.6 19.3 6.3 18.2 PAN2 "hPAN2, KIAA0710, USP52" ENSG00000135473 "Poly(A) specific ribonuclease subunit PAN2" Q504Q3 12 56316223-56334053 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "mRNA processing" "Exonuclease, Hydrolase, Nuclease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 23: Testis - Cell cycle regulation" "Cluster 30: Epithelial cell lines - Translation" "Cluster 52: Non-specific - Transcription" "unprognostic (2.43e-1)" "unprognostic (3.78e-1)" "unprognostic (1.21e-2)" "unprognostic (2.55e-1)" "unprognostic (1.67e-1)" "unprognostic (9.10e-3)" "unprognostic (1.03e-1)" "unprognostic (7.28e-2)" "unprognostic (7.35e-3)" "unprognostic (3.80e-1)" "unprognostic (1.74e-3)" "unprognostic (4.23e-3)" "prognostic unfavorable (2.77e-4)" "unprognostic (4.19e-1)" "unprognostic (3.87e-1)" "unprognostic (2.10e-1)" "unprognostic (2.68e-2)" 6.6 8.7 4.2 5.8 6.1 7.4 7.4 6.0 6.0 8.3 6.9 8.0 9.9 9.1 14.1 5.0 9.7 6.6 7.1 4.1 4.5 7.6 16.0 7.3 8.5 5.3 5.2 12.7 10.0 14.1 11.6 8.2 5.4 6.7 8.2 16.0 7.9 8.2 6.9 8.3 8.7 7.5 4.7 10.1 9.5 13.5 5.7 16.8 14.8 6.7 10.0 7.0 6.7 7.9 4.3 6.4 15.5 4.9 13.3 15.0 10.1 3.2 4.4 7.1 3.2 3.9 8.3 11.8 12.2 6.3 3.8 8.8 18.6 12.3 4.0 5.2 8.8 15.1 6.6 3.8 11.7 3.3 7.8 14.0 16.3 7.6 22.0 18.7 5.4 24.2 10.3 28.4 4.2 9.4 11.3 7.9 5.2 7.2 4.2 9.7 11.0 21.5 7.0 3.4 12.1 11.0 6.2 7.9 8.0 17.2 10.2 6.4 2.3 7.0 7.0 3.3 3.0 23.9 10.3 7.8 8.7 6.8 6.2 3.2 3.3 1.3 1.3 4.4 1.9 1.6 1.1 1.9 4.2 1.3 2.2 2.7 0.2 2.3 2.2 1.7 1.7 2.0 4.2 6.1 6.0 6.0 4.1 4.5 5.3 5.2 5.4 4.7 5.7 7.9 9.7 9.6 17.0 19.2 11.1 5.1 5.4 3.8 6.8 27.4 9.5 10.2 9.8 2.8 8.3 5.5 27.1 8.2 7.9 5.4 1.9 3.7 1.8 8.6 9.4 9.4 14.4 13.3 11.0 2.2 4.8 7.2 18.3 13.7 6.3 15.0 10.4 18.3 5.4 15.2 13.9 10.8 4.1 7.0 5.0 2.6 11.1 8.2 1.8 9.4 5.2 7.3 3.1 10.1 32.1 2.8 8.7 6.4 9.2 4.1 7.3 3.5 13.4 17.1 6.6 11.4 6.9 26.9 7.6 7.1 3.8 5.1 6.6 12.6 9.5 3.6 PARP1 "ADPRT, ARTD1, PARP, PPOL" ENSG00000143799 "Poly(ADP-ribose) polymerase 1" P09874 1 226360210-226408154 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Transcription, Transcription regulation" "DNA-binding, Glycosyltransferase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 469.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000147, CAB003839, CAB003840, HPA045168, CAB075726, CAB075727" Supported Supported Enhanced Nucleoplasm,Nucleoli NA NA 150000 "Cluster 43: B-cells - Humoral immune response" "Cluster 16: Immune cells - Immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Nucleoplasm Nucleoli "CAB000147: AB_430876, CAB003839: AB_365493, CAB003840: AB_562187, CAB075726: AB_2665732, CAB075727: AB_2665733, HPA045168: AB_2679240" "unprognostic (2.02e-1)" "unprognostic (9.40e-2)" "unprognostic (7.44e-3)" "unprognostic (1.32e-1)" "unprognostic (4.29e-1)" "unprognostic (9.22e-2)" "prognostic unfavorable (3.40e-4)" "unprognostic (2.20e-1)" "unprognostic (3.62e-2)" "unprognostic (1.39e-1)" "unprognostic (2.13e-1)" "unprognostic (1.66e-1)" "prognostic unfavorable (1.35e-5)" "unprognostic (2.38e-2)" "unprognostic (1.82e-1)" "unprognostic (3.14e-2)" "unprognostic (2.64e-1)" 32.0 26.4 33.9 63.9 41.9 29.4 29.5 46.2 33.2 26.2 20.6 43.5 29.3 30.2 19.8 31.3 28.9 20.4 55.1 30.3 36.2 22.4 37.1 27.4 125.5 48.4 39.7 27.5 50.8 94.7 38.0 58.2 47.7 40.7 37.2 44.9 28.9 46.4 94.5 21.1 36.8 45.6 41.9 57.7 29.6 40.5 40.9 64.6 28.4 70.2 150.8 38.7 24.6 58.1 182.4 108.9 295.4 209.3 75.9 61.3 137.1 101.3 119.1 178.2 144.9 175.4 98.1 559.3 147.2 80.9 77.9 135.1 411.6 132.4 144.4 204.1 396.6 216.2 135.9 114.5 44.6 372.2 93.3 61.7 50.5 144.2 101.3 49.3 140.5 132.2 346.9 291.8 94.1 99.6 114.7 110.0 476.2 290.5 165.1 334.2 484.5 533.4 76.4 144.5 264.0 229.2 165.2 190.3 100.1 205.3 159.6 225.8 99.3 93.3 140.9 120.6 235.1 110.9 151.8 472.6 78.2 125.7 214.3 11.1 11.7 12.3 31.2 20.5 45.3 72.2 37.3 36.7 28.2 69.9 28.2 32.5 2.2 22.0 42.3 16.2 49.3 25.7 33.9 41.9 46.2 33.2 30.3 36.2 48.4 39.7 47.7 41.9 40.9 58.1 33.4 54.5 73.6 13.7 169.1 72.3 83.9 56.4 51.2 96.1 58.8 43.3 115.0 44.3 69.8 57.0 141.8 469.2 53.8 27.7 72.4 88.9 34.1 53.3 66.5 62.0 75.0 100.5 16.5 107.0 111.7 49.8 37.8 55.2 122.1 116.2 34.2 69.4 139.6 90.9 17.5 50.0 57.0 47.8 35.7 20.5 40.0 48.3 62.2 16.9 76.9 80.1 95.8 10.1 31.9 48.5 24.2 35.0 186.9 82.8 25.6 48.5 56.4 118.1 46.0 58.7 48.0 88.8 199.6 77.2 48.2 137.6 85.0 103.5 61.9 41.7 PARP10 "ARTD10, FLJ14464" ENSG00000178685 "Poly(ADP-ribose) polymerase family member 10" Q53GL7 8 143977153-144012772 "Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "plasmacytoid DC: 16.5" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA028122, HPA052427" Approved Supported "Nucleoli rim,Golgi apparatus,Cytosol" No No "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 63: NK-cells & T-cells - Immune response" "Nucleoli rim" "Golgi apparatus, Cytosol" "HPA028122: AB_10601979, HPA052427: AB_2681828" "unprognostic (9.80e-3)" "unprognostic (5.89e-2)" "unprognostic (2.63e-3)" "unprognostic (9.10e-2)" "unprognostic (1.74e-2)" "unprognostic (1.46e-2)" "unprognostic (7.37e-2)" "unprognostic (3.61e-1)" "unprognostic (9.05e-2)" "unprognostic (7.17e-2)" "unprognostic (1.71e-1)" "unprognostic (1.05e-1)" "unprognostic (4.69e-3)" "unprognostic (1.09e-3)" "unprognostic (4.17e-2)" "unprognostic (8.69e-2)" "unprognostic (5.30e-3)" 25.2 34.9 10.0 36.3 10.6 23.7 24.6 9.8 13.2 31.8 10.4 33.2 28.4 29.1 3.7 21.5 35.7 9.9 13.8 9.0 10.4 38.4 39.7 34.7 35.8 16.0 11.0 40.6 21.7 6.2 26.0 10.2 12.5 35.7 4.9 6.4 38.3 16.6 18.3 23.1 35.4 7.3 13.3 61.2 25.6 35.4 12.3 34.2 29.4 4.5 10.6 17.8 25.1 11.9 17.8 1.8 1.2 3.3 8.4 7.3 9.3 3.0 3.7 18.7 21.0 0.9 29.6 21.9 39.8 9.2 21.4 6.7 0.4 10.1 0.8 49.5 0.1 24.1 10.8 11.0 7.8 9.5 27.7 4.7 9.9 9.3 3.8 2.1 2.9 30.6 0.4 16.9 3.7 21.4 33.4 16.5 1.0 0.2 13.9 30.8 3.5 29.4 7.7 21.6 1.0 1.1 19.8 2.0 38.8 0.4 22.0 13.9 13.1 9.6 14.2 16.4 10.9 28.4 18.3 5.1 13.9 31.6 5.3 0.0 2.4 3.6 4.4 2.8 2.7 1.1 2.1 3.6 2.3 2.0 1.5 2.4 1.0 1.8 2.8 16.5 1.5 3.5 10.0 10.6 9.8 13.2 9.0 10.4 16.0 11.0 12.5 13.3 12.3 11.9 22.3 3.2 5.2 10.4 19.1 7.6 8.2 10.7 17.6 5.7 12.3 16.0 3.2 7.2 6.3 9.2 14.6 2.2 42.2 20.5 1.9 9.2 6.2 12.0 12.7 10.7 19.2 5.7 0.4 5.6 4.0 12.7 23.9 13.3 19.1 25.9 9.3 21.1 12.0 0.0 0.6 17.3 6.1 16.6 6.8 7.9 15.8 21.4 7.2 12.2 25.8 13.4 34.0 4.5 1.0 6.5 13.8 11.3 15.2 4.5 22.0 25.1 6.7 20.4 6.6 11.7 13.4 19.6 9.1 10.4 4.7 1.4 27.0 17.7 16.4 4.0 PARP11 "ARTD11, C12orf6" ENSG00000111224 "Poly(ADP-ribose) polymerase family member 11" Q9NR21 12 3791047-3873448 "Metabolic proteins, Predicted intracellular proteins" "Differentiation, mRNA transport, Protein transport, Spermatogenesis, Translocation, Transport" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 61.5;Granulosa cells: 72.0;Late spermatids: 45.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026895 Uncertain Supported "Nucleoplasm,Nuclear bodies,Cytosol" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 40: Granulosa cells - Unknown function" "Nuclear bodies" "Nucleoplasm, Cytosol" "HPA026895: AB_1854980" "unprognostic (9.58e-2)" "unprognostic (1.77e-1)" "unprognostic (1.37e-1)" "unprognostic (1.80e-1)" "unprognostic (1.88e-1)" "unprognostic (4.12e-2)" "unprognostic (6.14e-2)" "unprognostic (1.49e-2)" "unprognostic (2.53e-1)" "unprognostic (2.61e-1)" "unprognostic (3.58e-2)" "unprognostic (2.32e-2)" "unprognostic (2.50e-1)" "unprognostic (2.11e-1)" "unprognostic (7.52e-2)" "unprognostic (3.81e-2)" "unprognostic (2.87e-2)" 3.4 5.0 2.7 5.0 2.9 3.2 5.3 2.0 2.9 4.2 2.0 3.6 3.7 6.5 5.4 3.1 4.1 4.0 2.3 2.5 3.4 3.9 4.5 3.8 10.2 3.4 3.2 8.2 2.5 7.8 1.8 3.2 3.3 8.6 4.1 3.3 4.0 4.2 1.8 2.2 3.7 5.2 2.8 6.2 3.3 9.4 3.5 10.4 9.1 2.9 9.4 5.0 1.9 3.5 2.7 2.3 14.0 2.3 4.4 7.2 4.1 3.3 5.5 5.6 5.7 8.7 2.2 8.0 2.0 6.4 6.6 2.2 4.8 4.8 9.0 16.1 4.9 12.0 0.0 6.5 5.1 8.1 4.4 5.9 3.8 4.4 12.4 0.0 4.4 15.3 3.1 6.5 8.1 4.0 4.2 3.1 5.2 2.9 0.3 8.3 9.8 1.8 2.6 6.3 0.9 2.9 3.1 2.8 4.2 15.1 0.5 7.1 8.5 4.9 4.8 7.3 4.4 3.1 7.3 11.7 4.6 4.4 1.2 20.3 8.9 9.2 7.4 7.4 10.0 10.0 8.3 5.5 8.9 8.8 9.2 7.5 8.5 7.7 6.1 7.8 3.7 6.2 2.7 2.9 2.0 2.9 2.5 3.4 3.4 3.2 3.3 2.8 3.5 3.5 8.6 9.6 9.5 16.0 18.3 1.9 4.4 6.7 7.4 10.6 5.7 4.1 3.8 2.8 4.5 1.8 2.1 4.2 17.7 2.6 0.0 3.4 61.5 2.1 9.6 5.3 3.6 12.0 30.8 3.1 1.6 8.4 1.1 1.9 14.7 72.0 6.8 4.1 7.1 3.3 30.8 4.7 2.0 9.8 5.8 45.1 10.5 9.7 1.8 18.7 10.3 5.4 17.5 32.6 18.8 3.3 7.6 8.6 3.7 6.6 2.6 4.1 6.0 6.4 6.6 7.0 9.8 9.9 10.9 3.6 1.8 2.6 15.0 8.9 5.0 3.4 PARP12 "ARTD12, FLJ22693, PARP-12, ZC3H1, ZC3HDC1" ENSG00000059378 "Poly(ADP-ribose) polymerase family member 12" Q9H0J9 7 140023749-140062951 "Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 48.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+ SV40 Large T+ RasG12V: 42.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA003584, HPA063872" Approved Approved Nucleoplasm NA NA "Cluster 35: T-regs - Unknown function" "Cluster 14: B-cells - Humoral immune response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "HPA003584: AB_1079568, HPA063872: AB_2685139" "unprognostic (1.46e-3)" "unprognostic (2.93e-2)" "unprognostic (1.73e-1)" "unprognostic (2.71e-2)" "unprognostic (6.74e-2)" "unprognostic (1.42e-1)" "prognostic unfavorable (1.63e-4)" "unprognostic (2.30e-2)" "unprognostic (1.15e-2)" "unprognostic (4.86e-3)" "unprognostic (7.51e-3)" "unprognostic (2.68e-1)" "prognostic unfavorable (4.12e-7)" "unprognostic (3.31e-2)" "unprognostic (2.76e-1)" "unprognostic (1.75e-2)" "unprognostic (6.01e-2)" 6.4 4.7 4.1 12.3 4.3 15.8 6.6 3.6 5.3 4.0 5.2 12.1 18.3 7.6 9.6 4.8 8.1 9.3 5.9 3.6 4.2 5.0 7.8 15.4 13.4 8.3 4.4 6.3 9.2 10.2 2.3 9.9 5.4 7.0 11.6 1.8 17.2 4.8 2.9 15.0 18.1 7.9 6.3 17.1 13.1 10.4 4.9 10.7 5.8 2.5 9.5 8.7 2.4 5.0 20.8 7.6 0.6 0.8 2.4 5.7 15.1 4.7 10.4 36.3 42.5 4.9 12.6 8.6 11.5 3.9 28.0 9.3 5.4 17.6 6.0 33.4 8.7 9.2 4.9 6.8 15.2 2.4 6.2 5.7 6.7 12.7 15.5 9.9 28.2 10.4 19.0 6.0 2.7 8.4 25.7 14.3 1.3 10.7 18.0 15.2 0.0 2.7 7.1 7.9 4.6 0.0 14.2 7.7 11.2 0.7 9.2 5.6 31.0 4.3 10.2 0.3 14.5 0.5 1.5 2.0 7.9 12.2 5.2 1.2 3.0 4.3 1.5 5.5 1.3 1.7 2.1 1.6 2.1 2.4 0.9 0.7 1.0 2.5 6.4 0.2 5.8 1.2 4.1 4.3 3.6 5.3 3.6 4.2 8.3 4.4 5.4 6.3 4.9 5.0 24.1 6.4 10.6 2.6 17.9 6.5 7.2 4.4 8.0 2.9 6.2 5.5 5.4 7.2 5.8 11.0 2.1 6.0 13.0 48.9 1.9 13.9 0.7 7.0 6.4 18.1 24.0 4.8 1.2 26.0 19.1 6.9 18.3 6.3 19.7 38.2 7.9 10.9 24.2 0.0 2.6 19.4 4.1 13.6 9.7 0.9 7.2 20.5 7.2 26.2 17.5 2.9 11.3 9.5 3.1 35.2 37.0 7.2 8.3 12.4 44.2 6.9 9.0 2.5 0.0 7.3 7.9 35.0 15.6 8.7 9.9 2.1 15.6 8.4 11.6 10.6 PARP14 "ARTD8, KIAA1268, pART8" ENSG00000173193 "Poly(ADP-ribose) polymerase family member 14" Q460N5 3 122680839-122730840 "Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Immunity, Innate immunity, Transcription, Transcription regulation" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 246.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+ SV40 Large T+: 74.7;BJ hTERT+ SV40 Large T+ RasG12V: 113.1" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA008846, HPA012063" Supported Supported Cytosol NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 64: Macrophages - Immune response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 44: Endometrium - Transcription" Cytosol "HPA008846: AB_1854982, HPA012063: AB_1854981" "unprognostic (4.38e-2)" "unprognostic (1.07e-2)" "unprognostic (1.25e-1)" "unprognostic (1.95e-2)" "unprognostic (2.56e-1)" "unprognostic (2.50e-3)" "unprognostic (1.87e-1)" "unprognostic (1.33e-1)" "unprognostic (1.44e-1)" "unprognostic (4.20e-2)" "unprognostic (1.74e-3)" "unprognostic (1.62e-2)" "prognostic unfavorable (1.79e-4)" "unprognostic (7.87e-2)" "unprognostic (3.82e-2)" "unprognostic (1.58e-3)" "unprognostic (1.71e-2)" 14.0 12.6 4.3 24.3 5.1 20.1 11.3 3.6 2.7 11.4 5.5 11.5 15.3 8.2 2.4 9.0 10.7 15.2 11.1 2.8 5.1 14.9 24.5 33.5 24.0 15.1 5.9 9.2 7.8 7.3 7.6 17.8 8.6 13.0 8.7 1.1 11.7 7.2 5.0 5.3 17.5 10.2 10.9 37.4 11.7 2.2 8.9 15.4 14.7 8.3 26.8 13.7 9.4 7.8 15.6 13.0 8.0 8.3 9.1 26.2 0.0 6.1 40.1 74.7 113.1 6.9 28.7 0.0 24.2 13.4 41.8 11.5 11.9 11.6 15.0 24.0 1.5 14.6 5.8 8.7 20.4 6.4 6.8 14.7 4.7 13.0 4.8 16.4 32.2 12.3 7.0 22.7 2.1 7.9 24.8 1.5 1.1 2.1 11.1 34.2 8.3 4.3 9.5 16.2 0.6 0.0 15.3 3.1 14.1 0.8 5.7 9.3 22.0 4.0 9.4 2.3 5.5 8.7 1.6 2.7 12.0 13.8 7.2 13.1 10.8 5.8 8.6 13.7 7.2 12.8 4.5 5.6 5.6 20.3 3.6 4.1 29.5 9.5 14.7 0.7 9.9 4.3 4.3 5.1 3.6 2.7 2.8 5.1 15.1 5.9 8.6 10.9 8.9 7.8 111.5 246.8 98.4 17.3 115.3 16.8 17.0 35.9 13.1 2.1 19.6 15.6 14.6 24.3 65.9 25.8 4.2 14.1 64.9 43.0 3.9 36.0 0.3 118.8 59.8 94.7 10.7 18.5 0.5 41.2 28.4 37.2 24.5 149.8 32.2 69.6 67.1 32.5 36.5 0.0 3.0 18.2 26.4 61.6 39.9 2.1 28.0 83.9 16.0 124.6 132.2 15.1 58.7 47.3 1.1 44.0 20.2 17.3 50.9 31.8 29.5 11.5 73.0 1.0 13.1 32.7 30.3 1.9 1.1 13.7 10.5 4.8 51.4 42.8 16.0 25.9 PARP15 "ARTD7, FLJ40597, pART7" ENSG00000173200 "Poly(ADP-ribose) polymerase family member 15" Q460N3 3 122577628-122639047 "Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "bone marrow: 23.1;intestine: 42.1;lymphoid tissue: 67.2" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 19.2;B-cells: 88.4;dendritic cells: 38.6;granulocytes: 19.6;NK-cells: 21.6;Plasma cells: 18.6;T-cells: 31.1" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "HEL: 7.6;JURKAT: 5.1;REH: 3.5;THP-1: 3.7;TIME: 8.9" "Low region specificity" "Detected in single" HPA035757 Approved Mitochondria "Intracellular and membrane" NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 16: Immune cells - Immune response" "Cluster 36: HEL - Hemostasis" "Cluster 57: B-cells - Immune response" Mitochondria "HPA035757: AB_10669656" "unprognostic (8.19e-3)" "unprognostic (2.88e-3)" "unprognostic (1.12e-1)" "unprognostic (1.18e-3)" "unprognostic (1.22e-1)" "unprognostic (9.01e-5)" "unprognostic (4.79e-2)" "unprognostic (1.83e-2)" "unprognostic (3.91e-2)" "unprognostic (5.40e-2)" "unprognostic (1.61e-1)" "unprognostic (9.63e-2)" "unprognostic (9.24e-7)" "unprognostic (9.03e-2)" "unprognostic (2.07e-2)" "unprognostic (1.52e-1)" "unprognostic (1.22e-2)" 3.7 1.2 3.1 25.7 2.7 23.1 1.8 4.2 3.8 1.7 1.2 3.8 2.6 1.9 1.3 2.0 2.0 4.4 1.7 2.1 1.2 1.7 3.2 9.0 44.4 1.8 2.3 0.7 0.8 0.2 0.7 2.5 1.7 1.8 4.8 2.2 2.2 1.1 6.0 1.2 42.1 1.9 0.7 67.2 4.1 2.5 2.0 8.3 3.0 1.9 50.3 4.5 1.6 3.6 0.3 0.2 0.3 0.3 0.1 0.2 0.3 0.2 0.1 0.0 0.0 0.2 0.7 0.3 0.4 0.1 0.2 0.3 0.0 0.0 0.0 0.7 0.1 7.6 0.5 0.3 0.1 0.5 0.3 1.5 0.1 0.3 0.1 0.2 1.7 5.1 0.2 1.3 0.0 0.3 2.3 0.4 0.4 0.1 0.1 3.5 0.2 0.3 0.0 0.6 0.5 0.3 0.1 0.1 0.1 0.3 0.5 3.7 8.9 0.2 0.6 0.3 0.2 0.6 0.4 1.6 0.4 0.2 0.1 1.8 0.2 0.1 7.2 0.3 5.8 9.4 4.4 5.4 0.8 9.3 3.8 4.8 0.5 3.9 0.7 1.0 4.2 2.2 3.1 2.7 4.2 3.8 2.1 1.2 1.8 2.3 1.7 0.7 2.0 3.6 0.8 19.2 15.9 0.0 88.4 0.5 0.0 0.0 0.0 0.0 0.6 0.6 0.7 0.0 2.1 0.0 0.0 0.1 38.6 0.1 0.0 0.0 0.2 0.3 0.1 1.2 0.0 7.4 0.1 0.0 0.1 2.7 2.6 0.3 19.6 0.0 2.2 0.6 8.3 0.0 0.2 0.0 0.0 5.1 1.4 0.2 0.0 6.4 1.8 6.5 4.7 0.0 21.6 0.0 0.1 0.1 0.0 0.0 18.6 0.0 0.0 0.1 10.5 0.0 0.0 0.7 0.4 0.1 1.6 0.4 0.0 0.3 31.1 0.0 0.0 0.0 PARP16 "ARTD15, C15orf30, FLJ20509, FLJ25281, pART15" ENSG00000138617 "Poly(ADP-ribose) polymerase family member 16" Q8N5Y8 15 65234460-65300618 "Metabolic proteins, Predicted membrane proteins" "Unfolded protein response" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Rod photoreceptor cells: 33.0;Spermatogonia: 28.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017081 Approved NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA017081: AB_10963218" "unprognostic (1.17e-2)" "unprognostic (6.51e-3)" "unprognostic (2.82e-2)" "unprognostic (6.37e-2)" "unprognostic (7.38e-2)" "unprognostic (2.88e-2)" "unprognostic (3.05e-2)" "unprognostic (6.82e-2)" "unprognostic (2.18e-1)" "unprognostic (2.70e-1)" "unprognostic (1.00e-1)" "unprognostic (1.78e-1)" "unprognostic (3.41e-3)" "unprognostic (1.11e-1)" "unprognostic (2.71e-1)" "unprognostic (1.01e-1)" "unprognostic (9.61e-2)" 6.6 9.8 5.0 4.7 4.8 6.0 8.8 7.0 5.6 12.6 4.4 10.2 6.2 8.7 5.1 7.5 9.7 4.3 4.9 4.9 4.9 6.2 13.2 5.1 7.0 4.8 4.8 11.9 7.5 8.2 5.5 6.0 4.9 8.4 6.4 5.1 7.2 6.2 3.8 8.1 7.1 6.8 4.7 6.5 7.9 4.8 4.9 10.0 6.4 3.9 8.2 10.0 9.1 5.1 6.0 6.3 6.5 10.4 5.3 4.9 2.8 2.8 7.1 7.0 7.3 4.5 5.4 18.9 7.3 3.5 15.3 9.4 30.3 3.7 5.0 7.3 11.3 3.1 6.5 6.3 9.1 8.7 5.6 6.1 6.0 2.0 7.2 10.6 6.4 17.9 7.6 7.1 5.9 6.8 19.0 8.8 2.8 29.7 8.2 33.5 11.8 14.3 5.0 5.3 10.8 7.2 8.3 7.5 6.8 5.1 8.7 7.5 2.7 8.5 6.5 4.7 3.9 13.3 16.5 24.2 7.0 12.5 4.2 19.9 3.9 12.2 12.6 6.0 14.0 8.5 11.9 12.8 5.2 11.1 14.7 10.9 15.0 12.5 6.5 4.4 10.8 6.9 5.0 4.8 7.0 5.6 4.9 4.9 4.8 4.8 4.9 4.7 4.9 5.1 3.7 3.2 3.1 10.1 9.6 5.2 6.0 3.9 9.6 12.1 5.0 4.7 4.1 7.2 3.4 3.7 0.0 12.5 9.1 3.4 0.0 5.8 0.8 1.5 4.7 4.5 1.8 3.0 14.0 9.1 5.7 7.0 11.7 2.7 0.0 6.5 2.9 6.0 3.8 3.3 18.3 4.9 4.1 2.5 1.7 1.9 9.9 4.3 3.6 11.2 4.3 7.3 9.2 10.6 13.4 5.3 2.5 7.9 9.8 3.2 7.1 4.0 2.6 33.0 6.6 4.3 4.5 1.6 28.6 4.6 4.3 5.5 9.0 6.3 5.4 3.0 PARP2 "ADPRTL2, ARTD2" ENSG00000129484 "Poly(ADP-ribose) polymerase 2" Q9UGN5 14 20343615-20357904 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair" "DNA-binding, Glycosyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA052003 Approved Supported Nucleoplasm,Nucleoli NA Yes "Cluster 16: MAIT-cells - Unknown function" "Cluster 54: Non-specific - Microtubule organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm Nucleoli "HPA052003: AB_2681689" "unprognostic (3.93e-1)" "unprognostic (7.92e-2)" "unprognostic (4.12e-1)" "unprognostic (1.24e-1)" "unprognostic (3.40e-2)" "unprognostic (7.30e-2)" "prognostic unfavorable (6.48e-4)" "unprognostic (1.97e-2)" "unprognostic (4.43e-2)" "unprognostic (9.35e-3)" "unprognostic (1.44e-2)" "unprognostic (1.42e-2)" "unprognostic (3.37e-3)" "unprognostic (2.83e-1)" "unprognostic (9.19e-2)" "unprognostic (1.91e-1)" "unprognostic (2.89e-2)" 17.7 21.1 21.1 10.7 22.0 26.8 17.5 21.4 31.4 18.1 16.4 19.3 12.8 20.9 17.8 14.6 17.5 10.0 17.1 22.5 21.0 15.5 17.2 13.5 14.5 19.5 18.9 22.9 17.9 11.1 21.0 12.9 19.8 13.9 14.0 26.4 14.2 13.4 32.4 19.2 14.2 15.8 19.0 16.5 16.3 23.8 19.8 11.9 16.7 27.1 17.9 13.8 15.3 22.1 55.5 39.5 59.7 45.3 19.4 18.4 43.4 60.2 32.5 74.8 91.8 36.8 51.3 40.4 26.5 19.0 64.8 50.1 78.3 27.5 87.8 32.4 38.3 37.2 46.6 63.3 17.3 77.9 20.4 12.5 23.0 45.5 51.1 20.5 38.5 48.0 39.2 53.4 52.3 33.5 40.1 33.0 33.0 62.8 60.0 49.7 79.7 26.5 30.0 28.2 41.3 28.3 65.3 36.8 17.9 37.4 34.2 25.8 26.6 45.3 68.1 31.5 48.1 49.3 67.7 53.4 19.0 33.3 51.4 1.9 5.0 0.5 8.9 4.8 11.7 6.8 8.4 7.9 5.5 4.1 9.0 8.6 0.1 7.6 2.6 5.6 5.3 4.8 21.1 22.0 21.4 31.4 22.5 21.0 19.5 18.9 19.8 19.0 19.8 22.1 12.1 25.6 6.5 7.2 9.5 6.5 10.5 16.1 18.8 29.2 7.4 10.0 14.0 5.7 19.9 7.3 12.5 25.8 10.2 4.5 7.9 12.8 9.3 9.9 13.3 11.0 4.8 30.3 17.6 8.7 22.2 11.6 7.7 11.3 8.2 18.4 6.8 10.1 11.9 30.3 15.5 5.0 14.2 4.6 5.1 9.8 11.5 6.6 8.8 9.4 4.2 20.7 6.2 6.0 9.3 10.1 4.5 17.0 19.1 4.5 5.3 7.4 28.0 23.2 6.6 9.8 18.5 20.9 41.5 11.3 4.8 14.9 6.2 16.7 7.4 7.0 PARP3 "ADPRT3, ADPRTL3, ARTD3, hPARP-3, IRT1, pADPRT-3" ENSG00000041880 "Poly(ADP-ribose) polymerase family member 3" Q9Y6F1 3 51942345-51948867 "FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair" "Glycosyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Proximal enterocytes: 33.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020984, HPA067657" Supported Supported "Nucleoplasm,Nuclear bodies" Yes No "Cluster 15: NK-cells - Transcription" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 45: Enterocytes - Digestion" "Nucleoplasm, Nuclear bodies" "HPA020984: , HPA067657: AB_2685881" "prognostic favorable (6.39e-5)" "unprognostic (1.25e-1)" "unprognostic (1.54e-2)" "unprognostic (2.85e-2)" "unprognostic (7.31e-2)" "unprognostic (1.56e-1)" "unprognostic (4.13e-1)" "unprognostic (3.53e-2)" "unprognostic (2.26e-1)" "unprognostic (2.01e-1)" "unprognostic (7.44e-3)" "unprognostic (4.30e-1)" "prognostic favorable (1.25e-8)" "unprognostic (5.63e-2)" "unprognostic (1.77e-1)" "unprognostic (1.40e-2)" "unprognostic (4.65e-3)" 16.0 33.4 12.7 9.9 13.5 3.1 15.3 12.9 14.6 9.6 14.4 17.1 28.1 11.4 5.9 10.4 11.2 11.3 13.6 11.6 14.2 21.2 29.2 13.4 10.9 13.8 14.9 8.9 4.4 35.8 10.9 5.9 13.7 14.6 10.2 4.7 14.5 15.5 15.8 7.5 25.2 9.3 12.9 14.8 16.4 5.4 14.9 8.2 19.6 17.6 8.0 15.4 10.8 12.4 10.0 6.6 2.0 17.3 17.8 30.0 4.8 15.4 29.0 23.1 24.9 3.9 28.1 14.1 4.5 29.4 12.6 1.6 5.0 14.5 9.1 34.8 1.2 7.8 15.1 13.2 18.8 5.3 10.9 24.4 12.4 16.2 9.1 35.7 10.8 10.2 3.5 14.7 19.9 3.4 4.6 12.5 2.4 4.2 16.4 7.3 2.8 13.9 14.0 13.5 2.0 6.4 16.3 4.8 10.7 1.4 6.5 5.9 24.0 42.5 9.9 7.4 10.4 22.5 26.0 6.0 27.2 14.4 13.6 0.0 1.6 1.2 2.4 3.0 2.2 6.3 2.6 1.8 2.6 2.5 3.6 3.5 0.1 5.7 1.6 0.9 3.2 1.8 12.7 13.5 12.9 14.6 11.6 14.2 13.8 14.9 13.7 12.9 14.9 12.4 5.3 6.4 10.0 6.2 8.1 2.7 10.6 15.9 21.1 2.0 8.6 8.9 7.4 8.6 8.6 0.0 0.0 0.6 2.1 13.1 7.9 9.7 7.8 2.4 3.8 5.3 3.0 1.7 2.6 6.3 0.4 4.7 17.3 2.7 4.5 0.8 2.5 9.5 3.7 0.0 3.0 11.3 6.1 3.2 2.2 15.3 4.7 3.7 7.2 3.7 5.0 3.8 0.0 1.0 1.8 11.5 6.5 1.5 4.9 4.3 33.4 20.6 9.5 2.1 6.6 4.1 5.7 3.4 3.3 7.8 1.4 0.5 5.9 1.6 13.8 9.3 PARP4 "ADPRTL1, ARTD4, p193, VAULT3, VPARP, VWA5C" ENSG00000102699 "Poly(ADP-ribose) polymerase family member 4" Q9UKK3 13 24420931-24512778 "Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Ribonucleoprotein, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "granulocytes: 99.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011739 Approved Supported Nucleoplasm,Cytosol Yes No "Cluster 45: Eosinophils - Innate immune response" "Cluster 9: Intestine - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 11: Alveolar cells - Smell perception" Nucleoplasm Cytosol "HPA011739: AB_1854986" "unprognostic (1.61e-1)" "unprognostic (2.34e-2)" "unprognostic (1.62e-2)" "unprognostic (4.35e-2)" "unprognostic (2.46e-1)" "unprognostic (1.21e-1)" "unprognostic (1.20e-1)" "unprognostic (2.52e-1)" "unprognostic (2.45e-1)" "unprognostic (2.02e-2)" "unprognostic (4.12e-3)" "unprognostic (2.97e-2)" "prognostic favorable (1.21e-5)" "unprognostic (3.23e-2)" "unprognostic (1.71e-1)" "unprognostic (3.80e-2)" "unprognostic (2.84e-3)" 18.6 22.8 8.4 24.2 11.9 22.1 16.7 11.2 8.2 24.3 12.1 38.7 38.9 17.9 18.0 22.0 21.1 29.5 12.7 7.5 10.4 26.9 24.9 28.7 23.6 15.6 11.3 18.6 14.8 18.5 5.8 15.9 15.2 13.1 39.5 8.3 16.8 18.6 6.4 11.0 39.1 19.5 11.3 26.3 34.4 9.0 11.8 21.6 21.2 11.3 25.2 28.3 14.0 15.6 42.9 37.7 18.1 32.7 48.7 68.8 15.3 48.7 63.5 41.8 37.1 15.5 108.5 32.0 47.3 44.5 46.3 48.5 27.2 49.4 34.1 73.7 19.0 45.9 33.0 35.9 27.8 59.3 43.3 39.9 16.3 34.6 18.3 81.4 69.7 24.5 13.2 13.8 50.2 19.9 37.6 28.5 20.5 100.6 45.9 35.0 33.8 45.0 77.6 86.7 16.4 20.9 35.7 14.2 33.5 23.4 7.1 48.2 99.7 18.9 19.8 24.4 50.4 15.6 19.3 41.4 34.3 30.6 42.1 50.0 21.1 45.9 20.4 25.7 20.4 14.2 16.8 20.5 27.9 8.0 12.2 14.8 24.0 21.1 34.6 10.4 21.9 20.1 8.4 11.9 11.2 8.2 7.5 10.4 15.6 11.3 15.2 11.3 11.8 15.6 20.5 51.3 51.8 21.2 20.5 2.8 6.9 29.2 6.2 6.3 10.2 5.8 17.6 17.2 52.6 25.8 2.1 5.0 33.8 74.2 5.9 26.1 5.4 35.9 19.4 19.8 4.9 13.9 1.5 22.5 8.9 18.3 42.8 50.9 99.2 30.7 31.1 16.0 17.7 1.7 2.1 27.0 18.3 23.4 6.9 4.7 11.8 35.3 8.8 36.5 37.1 6.7 36.0 21.1 40.8 30.9 53.8 8.2 27.0 10.6 59.7 18.2 69.7 7.4 6.6 12.2 10.4 2.5 8.9 13.5 3.8 1.9 28.9 24.1 30.8 20.5 PARP6 "ARTD17, pART17" ENSG00000137817 "Poly(ADP-ribose) polymerase family member 6" Q2NL67 15 72241181-72272999 "Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 178.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026991 Approved Approved "Plasma membrane" Yes No "Cluster 45: Eosinophils - Innate immune response" "Cluster 58: Brain - Synaptic function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 25: Spermatids - Spermatogenesis" "Plasma membrane" "HPA026991: AB_1854989" "unprognostic (3.88e-2)" "prognostic favorable (3.17e-5)" "prognostic unfavorable (3.37e-4)" "unprognostic (3.36e-1)" "unprognostic (7.13e-2)" "unprognostic (3.05e-1)" "unprognostic (2.37e-2)" "unprognostic (1.33e-1)" "unprognostic (2.00e-1)" "unprognostic (2.64e-1)" "unprognostic (8.55e-2)" "unprognostic (6.92e-2)" "prognostic unfavorable (8.02e-8)" "unprognostic (6.81e-2)" "unprognostic (1.14e-1)" "unprognostic (1.45e-1)" "unprognostic (4.42e-2)" 20.0 20.9 63.2 14.6 64.8 30.5 20.0 62.2 84.6 22.2 61.2 28.7 15.3 24.5 24.0 17.7 22.6 21.3 19.6 64.5 57.7 23.8 15.5 19.7 19.4 55.7 55.9 29.2 32.5 12.6 49.7 18.3 55.3 25.1 14.8 52.9 23.2 17.3 34.8 23.0 21.7 20.2 51.0 20.6 24.2 34.5 57.1 21.0 30.2 21.2 17.4 22.7 19.1 64.9 15.9 27.6 29.0 37.8 30.5 25.2 23.7 13.8 19.9 21.8 31.1 18.5 28.2 22.3 8.4 20.3 31.4 20.9 32.4 18.1 12.4 26.5 30.6 31.7 55.0 0.2 25.4 16.7 30.1 32.6 43.5 20.1 55.2 33.7 14.6 35.6 16.6 24.3 17.5 28.4 14.4 28.7 14.2 13.2 0.0 26.7 20.8 17.2 19.9 30.4 81.4 43.1 22.6 17.8 37.0 38.2 22.8 18.8 14.0 26.7 24.7 35.7 20.7 27.9 27.7 23.2 19.1 31.4 19.1 1.1 3.6 8.2 2.3 3.1 1.6 2.4 1.7 2.5 2.6 2.3 2.6 2.0 3.6 3.0 3.5 2.2 2.9 2.1 63.2 64.8 62.2 84.6 64.5 57.7 55.7 55.9 55.3 51.0 57.1 64.9 11.5 22.4 21.2 54.9 15.3 14.4 9.6 6.9 31.3 16.4 13.0 13.7 20.9 2.8 12.9 9.2 20.9 7.3 12.0 8.0 7.9 9.7 61.4 8.0 10.3 11.1 17.4 4.6 19.7 12.7 5.3 13.9 21.4 10.0 15.8 17.3 6.4 6.1 8.9 18.5 20.5 6.5 6.1 14.8 11.1 178.1 12.5 14.0 16.0 20.6 9.3 8.8 6.2 27.2 54.6 9.2 9.0 9.8 12.3 9.0 17.7 12.3 5.8 15.5 6.6 13.7 12.5 44.3 12.6 19.3 15.8 6.4 13.3 8.6 7.5 9.3 PARP8 "ARTD16, FLJ21308, pART16" ENSG00000151883 "Poly(ADP-ribose) polymerase family member 8" Q8N3A8 5 50665899-50846519 "Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 78.2" "Cell type enhanced" "Detected in many" "dendritic cells: 124.9;Excitatory neurons: 197.9;Inhibitory neurons: 139.3;Microglial cells: 112.4;Oligodendrocyte precursor cells: 158.3;T-cells: 157.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "THP-1: 91.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049183 Approved Approved "Nucleoplasm,Midbody ring,Cytosol" Yes No "Cluster 16: MAIT-cells - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 43: THP-1 - Innate immune response" "Cluster 24: Non-specific - Transcription regulation" Nucleoplasm "Midbody ring, Cytosol" "HPA049183: AB_2680667" "unprognostic (1.22e-2)" "unprognostic (2.53e-1)" "unprognostic (1.77e-1)" "unprognostic (1.05e-1)" "unprognostic (2.12e-1)" "unprognostic (6.33e-2)" "unprognostic (8.86e-3)" "unprognostic (7.27e-2)" "unprognostic (1.86e-2)" "unprognostic (8.96e-2)" "unprognostic (2.85e-1)" "unprognostic (6.81e-2)" "unprognostic (9.63e-2)" "unprognostic (2.84e-2)" "unprognostic (4.42e-2)" "unprognostic (4.23e-2)" "prognostic favorable (1.12e-4)" 11.7 13.1 4.6 26.8 8.8 78.2 9.2 0.0 7.9 8.3 0.3 8.8 14.5 6.6 4.2 7.7 9.9 25.7 6.9 14.7 12.6 7.0 8.0 19.8 42.0 3.4 4.5 11.6 12.2 13.8 4.9 12.4 0.1 11.3 9.3 4.6 10.3 7.4 4.8 7.6 15.0 8.4 2.7 43.6 20.2 9.1 7.7 19.2 43.1 2.1 22.5 14.5 5.4 2.0 24.8 0.1 12.2 18.8 3.2 5.7 18.0 4.3 15.7 4.1 12.0 0.9 33.5 14.8 16.9 0.5 43.3 12.4 2.1 13.1 10.0 20.2 15.9 10.6 9.2 1.1 6.3 28.1 0.2 6.8 10.9 8.5 6.0 24.6 0.2 23.1 1.6 9.1 5.9 8.8 31.8 32.5 12.3 0.4 6.0 15.4 24.0 17.1 7.6 12.8 13.0 19.0 13.8 21.6 3.7 17.6 1.0 91.2 0.0 1.0 15.4 1.2 12.6 6.9 0.2 29.5 13.8 7.6 17.7 27.4 13.7 31.9 43.6 4.0 70.6 13.4 34.3 50.5 9.2 16.7 20.9 34.9 28.6 39.5 2.9 4.2 22.5 22.7 4.6 8.8 0.0 7.9 14.7 12.6 3.4 4.5 0.1 2.7 7.7 2.0 6.2 32.1 21.1 29.4 51.7 8.0 5.2 12.7 26.2 13.6 10.4 6.5 5.6 14.3 19.1 22.0 0.0 22.5 124.9 17.2 7.9 14.2 28.7 11.8 8.4 3.9 15.0 7.4 197.9 10.2 6.4 13.4 46.9 10.6 14.5 12.6 6.8 5.0 14.3 6.7 139.3 4.2 8.2 26.1 16.9 15.3 1.2 27.1 8.8 112.4 43.4 0.7 93.7 158.3 7.3 18.7 8.4 3.0 65.0 7.7 8.2 4.3 25.6 2.1 6.6 12.3 13.0 12.8 6.0 14.3 4.0 24.8 157.3 6.5 9.6 13.7 PARP9 "ARTD9, BAL, BAL1" ENSG00000138496 "Poly(ADP-ribose) polymerase family member 9" Q8IXQ6 3 122527924-122564577 "Disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Antiviral defense, DNA damage, DNA repair, Immunity, Innate immunity" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+ SV40 Large T+: 95.8;BJ hTERT+ SV40 Large T+ RasG12V: 113.4;SK-MEL-30: 93.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA066708 Supported Nucleoplasm,Mitochondria,Cytosol NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 64: Macrophages - Immune response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Nucleoplasm, Cytosol" Mitochondria "HPA066708: AB_2685707" "unprognostic (3.06e-2)" "unprognostic (4.80e-2)" "unprognostic (1.55e-3)" "unprognostic (6.70e-3)" "unprognostic (1.11e-1)" "unprognostic (6.38e-2)" "unprognostic (4.73e-3)" "unprognostic (3.39e-3)" "unprognostic (1.31e-1)" "prognostic favorable (6.65e-4)" "unprognostic (1.00e-3)" "unprognostic (5.63e-3)" "unprognostic (1.56e-3)" "unprognostic (3.06e-2)" "unprognostic (3.70e-2)" "unprognostic (9.65e-3)" "unprognostic (1.56e-2)" 20.1 29.4 14.0 35.8 15.1 20.8 17.6 13.8 17.4 20.3 14.8 22.5 21.2 19.6 19.1 24.8 20.1 28.8 18.3 13.5 15.1 22.0 68.3 36.5 30.5 21.3 15.5 12.9 22.0 23.7 18.5 20.1 16.8 18.9 19.5 5.8 39.9 12.6 13.6 11.6 21.4 29.1 17.6 44.3 20.0 6.4 17.4 30.6 16.8 17.3 25.9 26.0 16.5 16.1 23.1 7.7 2.8 1.9 16.9 34.6 2.6 7.6 41.0 95.8 113.4 12.0 24.9 5.2 16.4 15.3 60.2 24.8 6.6 13.4 19.9 40.3 4.5 24.9 7.6 6.4 18.0 8.1 15.9 28.4 12.9 13.6 3.4 19.1 20.8 15.7 2.3 20.7 3.9 10.2 26.0 10.1 1.1 4.7 21.1 27.3 27.2 1.7 37.0 13.1 1.7 6.6 20.2 3.3 93.8 1.5 10.7 9.0 12.6 4.1 11.8 0.9 4.7 12.8 7.1 9.5 14.1 8.7 7.7 41.9 29.9 36.9 19.8 41.1 18.5 15.9 20.6 22.3 27.5 11.4 15.6 19.3 87.5 30.2 45.2 3.3 24.9 23.3 14.0 15.1 13.8 17.4 13.5 15.1 21.3 15.5 16.8 17.6 17.4 16.1 37.0 41.7 44.2 13.4 18.9 7.1 10.8 13.8 12.5 0.8 10.5 6.3 5.8 10.0 35.1 20.2 0.0 5.2 14.0 32.5 1.9 30.4 1.6 23.6 28.1 37.4 10.7 19.0 0.3 39.9 19.3 19.9 22.4 23.2 10.1 19.5 21.8 50.1 42.0 0.0 1.3 11.5 10.2 32.3 9.2 4.5 18.3 41.2 7.2 45.0 50.2 12.1 32.0 17.1 3.9 36.8 11.7 24.0 13.6 8.9 17.5 19.3 48.8 1.0 19.7 18.9 16.3 0.9 1.9 15.7 6.7 1.6 23.5 17.0 8.6 14.4 PASK "KIAA0135, PASKIN, STK37" ENSG00000115687 "PAS domain containing serine/threonine kinase" Q96RG2 2 241106099-241150264 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 19.8;lymphoid tissue: 22.9" "Cell type enhanced" "Detected in many" "Peritubular cells: 24.5;Theca cells: 26.5" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "basal ganglia: 19.8" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" "HPA016450, HPA021079" Uncertain Supported Cytosol NA Yes "Cluster 21: B-cells - Adaptive immune response" "Cluster 3: T-cells - Adaptive immune response" "Cluster 14: REH - Unknown function" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "HPA016450: AB_1854992, HPA021079: AB_1854993" "unprognostic (1.76e-2)" "unprognostic (1.29e-2)" "unprognostic (2.84e-1)" "unprognostic (1.41e-2)" "unprognostic (1.14e-1)" "unprognostic (8.99e-6)" "unprognostic (1.80e-2)" "unprognostic (1.48e-1)" "unprognostic (1.60e-3)" "unprognostic (1.58e-2)" "unprognostic (1.02e-2)" "unprognostic (6.35e-2)" "unprognostic (7.12e-2)" "unprognostic (1.52e-3)" "unprognostic (1.68e-1)" "unprognostic (6.44e-2)" "unprognostic (4.38e-3)" 1.6 1.1 3.7 7.1 19.8 8.8 2.1 1.0 5.3 2.5 3.1 2.4 3.4 2.1 3.9 3.3 6.1 2.0 1.1 2.7 1.7 3.7 1.4 3.2 13.7 1.9 1.9 1.9 3.6 2.4 4.6 1.0 1.8 10.0 2.3 11.9 2.9 1.4 0.8 4.1 4.5 1.2 0.3 4.1 3.0 16.1 3.2 22.9 5.1 0.2 7.8 2.1 2.2 5.2 7.4 9.9 12.9 16.7 1.1 1.9 17.4 7.0 2.2 6.3 8.8 8.1 7.4 3.8 1.4 1.5 13.8 17.9 15.1 6.1 4.6 15.6 13.8 10.6 19.1 14.4 0.8 14.7 16.0 0.9 4.7 6.5 1.9 2.6 4.6 16.2 14.0 5.2 4.5 8.0 17.5 15.4 14.6 8.8 5.9 27.5 13.3 4.7 2.5 16.0 23.1 7.0 3.9 8.0 3.2 6.8 6.7 10.5 6.1 8.8 7.7 11.1 9.6 6.8 7.4 18.1 5.4 10.9 8.2 4.4 0.6 0.5 1.0 0.4 0.9 4.5 3.9 3.5 0.8 3.9 2.3 2.6 0.8 1.9 0.7 0.4 4.1 2.2 3.7 19.8 1.0 5.3 2.7 1.7 1.9 1.9 1.8 0.3 3.2 5.2 2.3 3.2 7.9 2.6 8.5 2.7 1.2 1.6 2.2 2.6 3.5 4.3 3.1 2.8 1.9 3.7 4.2 0.9 2.2 3.1 0.0 1.5 14.9 13.9 1.6 8.5 0.0 13.3 12.5 2.0 1.7 2.7 3.6 4.4 3.8 11.7 17.5 1.5 2.0 1.7 6.1 3.5 0.0 4.7 2.0 3.5 5.9 2.1 12.4 3.7 2.7 2.1 7.2 0.5 2.6 0.9 1.0 24.5 4.7 1.7 1.9 1.4 12.3 18.7 0.0 2.1 2.1 16.1 12.7 2.6 1.4 0.3 19.1 26.5 3.9 0.9 PBK "CT84, FLJ14385, Nori-3, SPK, TOPK" ENSG00000168078 "PDZ binding kinase" Q96KB5 8 27809624-27838082 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "lymphoid tissue: 22.8;testis: 70.3" "Group enriched" "Detected in many" 5 "Early spermatids: 364.9;Spermatocytes: 436.4" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 282.8" "Group enriched" "Detected in many" 4 "basal ganglia: 4.7;white matter: 13.9" "Not detected" "Not detected" "HPA005753, HPA050656" Enhanced Supported Approved Cytosol NA Yes "Cluster 48: NK-cells - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" Cytosol "HPA005753: AB_1855018, HPA050656: AB_2681205" "unprognostic (7.17e-2)" "unprognostic (7.21e-3)" "unprognostic (1.04e-3)" "unprognostic (2.77e-2)" "unprognostic (1.50e-1)" "unprognostic (1.27e-1)" "prognostic unfavorable (8.29e-5)" "unprognostic (3.65e-3)" "unprognostic (7.38e-2)" "unprognostic (2.88e-3)" "prognostic unfavorable (6.56e-4)" "unprognostic (1.20e-1)" "prognostic unfavorable (1.18e-12)" "unprognostic (9.61e-2)" "unprognostic (1.86e-1)" "unprognostic (8.30e-2)" "unprognostic (8.68e-2)" 1.1 0.6 0.1 6.6 0.1 9.1 2.3 0.0 0.1 1.1 0.0 8.9 8.4 1.2 0.0 6.6 0.6 0.7 0.2 0.1 0.1 0.4 1.1 0.7 12.8 0.1 0.3 0.2 0.4 0.2 0.0 5.1 0.2 0.4 10.1 0.0 0.9 0.0 0.2 4.8 8.1 2.7 0.1 1.5 3.6 70.3 0.3 22.8 0.5 0.1 12.4 1.6 2.1 0.1 282.8 94.2 94.4 57.9 8.3 15.7 36.9 129.5 63.0 133.2 112.3 33.7 51.2 156.4 43.3 51.7 150.2 76.4 87.6 44.7 145.7 35.8 48.0 35.0 64.6 49.2 0.6 25.7 54.1 4.4 36.0 62.6 32.8 24.3 68.5 75.9 54.3 100.6 160.4 34.5 87.7 29.1 15.6 80.1 80.0 54.4 126.9 41.2 51.2 44.9 36.1 53.2 48.2 56.0 75.0 26.2 58.0 37.3 40.6 85.6 207.3 111.5 141.5 15.4 39.4 70.1 54.0 43.4 188.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.3 0.0 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.3 0.2 0.1 0.3 0.1 0.2 0.0 0.0 0.0 4.2 8.9 2.8 10.8 0.0 0.0 2.9 2.4 0.5 2.8 2.6 0.0 0.0 29.8 1.3 5.5 0.0 0.6 364.9 2.5 2.2 2.4 0.0 61.7 0.1 0.0 49.3 6.7 6.6 3.5 0.0 13.5 5.7 1.7 5.0 0.0 0.1 9.4 6.1 1.9 1.6 76.8 8.4 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.3 3.0 14.0 2.0 1.5 0.3 0.1 0.0 6.6 0.1 5.8 436.4 38.1 9.4 2.4 6.7 1.9 2.4 18.7 3.8 PCMT1 ENSG00000120265 "Protein-L-isoaspartate (D-aspartate) O-methyltransferase" P22061 6 149749443-149811420 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 1022.2;Late spermatids: 428.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003239 Approved Supported Cytosol No No 4100000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 47: Non-specific - Unknown function" "Cluster 1: K-562 - Erythropoiesis" "Cluster 29: Early spermatids - Spermatogenesis" Cytosol "HPA003239: AB_1079580" "prognostic unfavorable (4.02e-7)" "prognostic unfavorable (9.58e-4)" "unprognostic (1.35e-2)" "prognostic unfavorable (4.27e-4)" "unprognostic (1.02e-1)" "prognostic unfavorable (1.88e-4)" "prognostic unfavorable (2.58e-4)" "unprognostic (1.91e-2)" "unprognostic (1.58e-2)" "unprognostic (9.02e-2)" "unprognostic (6.45e-2)" "unprognostic (6.77e-2)" "unprognostic (6.14e-2)" "unprognostic (4.38e-1)" "unprognostic (1.70e-1)" "unprognostic (2.17e-2)" "prognostic unfavorable (6.38e-4)" 48.7 43.2 77.5 32.8 85.1 75.9 46.2 70.2 107.1 46.4 56.4 45.5 36.6 38.8 48.5 45.3 39.2 28.4 121.7 87.5 84.8 51.1 73.8 37.9 41.4 80.3 73.0 39.3 38.1 46.3 43.3 42.9 86.2 52.1 43.1 55.8 39.8 50.1 211.9 44.6 34.6 48.9 71.1 34.5 37.8 76.7 72.3 57.4 49.0 163.3 46.7 40.7 38.0 79.2 87.3 68.4 70.4 88.6 152.1 125.9 77.6 140.7 82.9 114.7 143.4 200.1 65.4 117.9 113.0 127.5 126.5 106.6 123.9 143.6 159.9 79.2 180.0 175.5 122.2 192.1 99.2 203.7 197.7 62.8 105.2 128.5 138.5 80.7 107.6 89.8 256.5 107.7 142.3 258.9 98.5 150.4 56.5 84.7 78.6 83.4 89.7 82.6 108.9 62.4 137.5 52.4 111.2 173.9 97.7 82.5 107.8 146.1 83.3 67.2 80.7 124.7 151.2 64.1 109.9 115.4 103.6 135.8 137.7 162.9 193.2 178.0 93.0 182.4 94.7 105.0 93.7 102.8 176.0 81.5 86.5 98.0 101.6 108.5 185.7 79.9 129.2 204.1 77.5 85.1 70.2 107.1 87.5 84.8 80.3 73.0 86.2 71.1 72.3 79.2 57.0 54.5 41.4 21.2 62.6 175.1 74.4 204.4 56.3 72.6 48.0 40.6 154.1 60.1 96.4 79.1 37.5 169.3 66.8 56.6 78.2 113.5 1022.2 51.9 58.4 69.8 55.2 170.1 77.0 110.7 214.0 79.2 26.0 48.8 107.7 38.8 53.9 115.6 119.1 65.6 52.8 72.9 187.2 78.7 127.5 428.1 71.7 78.2 138.7 31.9 143.7 121.2 74.2 30.7 72.2 106.6 57.9 73.7 71.8 67.8 65.1 89.3 106.2 66.3 111.7 64.0 110.4 224.9 96.3 60.7 157.6 148.3 83.0 55.0 58.7 59.1 PCYT1A "CT, CTPCT, PCYT1" ENSG00000161217 "Phosphate cytidylyltransferase 1, choline, alpha" P49585 3 196214222-196287957 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Nucleotidyltransferase, Transferase" "Cone-rod dystrophy, Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "EFO-21: 215.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA035428 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 38: EFO-21 - Unknown function" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm Cytosol "HPA035428: AB_10602045" "unprognostic (8.58e-3)" "unprognostic (2.63e-1)" "unprognostic (8.45e-2)" "unprognostic (8.61e-3)" "unprognostic (2.87e-1)" "unprognostic (1.85e-1)" "prognostic unfavorable (8.65e-5)" "unprognostic (8.52e-2)" "unprognostic (5.99e-2)" "unprognostic (1.65e-2)" "unprognostic (6.72e-3)" "unprognostic (1.74e-2)" "unprognostic (1.10e-1)" "unprognostic (2.11e-1)" "unprognostic (1.47e-2)" "unprognostic (7.16e-3)" "unprognostic (2.41e-2)" 31.4 24.4 15.2 30.0 16.0 45.3 21.0 16.6 15.8 16.7 17.8 25.7 60.3 19.1 13.9 31.0 15.6 20.7 46.4 15.5 21.1 18.3 20.7 22.5 22.9 18.8 18.0 15.8 16.8 22.7 12.9 20.1 18.5 16.6 22.9 14.4 19.3 18.6 73.8 43.0 49.1 23.0 17.5 25.9 24.2 22.4 18.1 18.1 17.2 42.1 26.8 21.0 19.8 17.1 92.6 36.6 25.8 37.2 52.2 53.9 37.0 68.2 47.1 59.2 51.8 92.3 32.8 23.9 215.2 78.1 60.2 71.4 40.5 52.1 50.4 42.1 28.6 68.6 40.6 39.5 45.2 34.3 56.7 47.4 40.0 55.9 39.6 35.4 63.0 21.0 38.3 53.3 58.1 79.6 19.9 17.3 21.4 55.7 53.0 34.5 31.0 37.5 35.7 53.6 25.4 18.3 44.5 79.5 44.2 32.8 114.1 37.2 88.5 45.5 25.2 61.8 92.7 45.8 101.1 44.1 69.6 43.8 56.9 9.6 9.2 10.4 8.8 9.3 7.5 7.2 6.5 9.7 9.1 6.3 4.2 6.3 21.0 9.4 11.0 5.9 14.9 5.2 15.2 16.0 16.6 15.8 15.5 21.1 18.8 18.0 18.5 17.5 18.1 17.1 24.7 16.0 25.7 15.3 19.9 14.5 9.4 19.7 14.2 15.9 14.1 9.4 70.1 20.0 17.5 14.7 25.0 11.9 27.3 36.4 13.7 24.8 76.3 17.8 22.9 23.2 22.1 12.2 20.4 22.9 17.7 17.0 23.4 15.6 20.8 16.1 26.7 35.6 37.4 8.4 22.7 24.2 6.1 34.6 27.1 67.6 19.9 33.9 19.6 20.6 39.4 13.1 39.1 16.1 17.6 24.6 21.1 28.2 27.2 12.0 67.2 23.2 33.9 12.8 26.3 15.0 19.0 46.0 13.2 30.0 21.5 18.6 25.6 25.5 23.8 12.2 PCYT1B "CCT-beta, CTB" ENSG00000102230 "Phosphate cytidylyltransferase 1, choline, beta" Q9Y5K3 X 24558087-24672677 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 13.2;retina: 12.1;testis: 13.4" "Cell type enhanced" "Detected in some" "Astrocytes: 23.5;Early spermatids: 29.1;Late spermatids: 90.1;Muller glia cells: 30.1;Oligodendrocyte precursor cells: 23.6;Oligodendrocytes: 41.9" "Cancer enhanced" "Detected in some" "glioma: 4.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 10.3;CACO-2: 22.2;HEL: 25.7;Hep G2: 10.2;NTERA-2: 11.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006367 Uncertain NA NA "Cluster 17: Basophils - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 36: HEL - Hemostasis" "Cluster 31: Spermatids - Spermatogenesis" "HPA006367: AB_1079585" "unprognostic (4.49e-1)" "unprognostic (2.20e-1)" "unprognostic (1.16e-1)" "unprognostic (7.39e-2)" "unprognostic (9.88e-2)" "unprognostic (6.83e-2)" "unprognostic (5.05e-2)" "unprognostic (2.92e-1)" "unprognostic (1.61e-2)" "unprognostic (1.67e-1)" "unprognostic (1.65e-2)" "unprognostic (5.64e-2)" "unprognostic (2.63e-6)" "unprognostic (2.62e-4)" "unprognostic (4.56e-2)" "unprognostic (1.75e-2)" "unprognostic (1.96e-4)" 0.1 0.8 12.1 0.2 12.2 0.8 0.1 10.6 12.8 0.7 7.5 1.2 0.3 1.6 0.6 0.8 2.2 0.4 2.9 13.2 9.8 0.2 0.0 0.7 0.0 9.5 10.2 1.4 1.5 0.0 1.3 1.3 9.8 0.8 0.2 12.1 0.1 2.4 0.0 0.1 0.6 2.5 8.6 0.2 0.2 13.4 11.4 0.5 0.0 0.0 0.0 0.3 0.3 12.9 0.0 0.0 10.3 0.1 0.0 0.0 0.1 0.0 0.9 0.3 0.1 22.2 0.0 0.0 5.2 0.0 0.0 1.0 4.2 0.0 0.0 0.0 0.1 25.7 0.0 10.2 0.1 0.0 0.3 0.0 0.1 0.3 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 3.9 0.5 11.4 0.0 0.0 0.0 1.4 0.0 0.0 0.0 7.2 5.8 0.0 0.0 0.5 7.1 0.1 0.0 0.0 0.0 0.3 0.0 0.5 0.2 0.0 0.0 4.4 0.7 0.3 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.1 0.1 0.0 0.2 12.1 12.2 10.6 12.8 13.2 9.8 9.5 10.2 9.8 8.6 11.4 12.9 0.0 0.0 0.0 23.5 0.0 0.0 0.2 0.1 0.0 0.4 0.0 0.5 1.6 0.0 0.7 0.0 0.0 0.1 0.0 0.0 0.0 0.8 29.1 10.7 0.2 0.1 1.8 1.3 5.6 0.0 0.0 0.4 0.0 0.2 4.5 5.8 0.0 0.0 0.0 0.0 9.1 0.0 0.0 0.0 0.0 90.1 0.3 0.9 0.0 3.7 0.3 30.1 0.0 23.6 41.9 0.2 0.0 2.6 0.1 0.1 0.0 0.5 6.4 1.6 0.0 0.0 1.0 1.8 0.5 0.0 0.0 0.0 0.0 0.8 0.0 0.1 PCYT2 ET ENSG00000185813 "Phosphate cytidylyltransferase 2, ethanolamine" Q99447 17 81900958-81911432 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Nucleotidyltransferase, Transferase" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 165.7;testis: 261.7" "Group enriched" "Detected in many" 7 "Early spermatids: 763.2;Late spermatids: 2829.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Hep G2: 218.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023033, HPA023034" Enhanced Approved Nucleoplasm,Cytosol NA NA 84000 "Cluster 26: Non-specific - Mitochondria" "Cluster 78: Testis - Spermatogenesis" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 25: Spermatids - Spermatogenesis" Cytosol Nucleoplasm "HPA023033: AB_1855094, HPA023034: AB_1855095" "unprognostic (4.05e-3)" "unprognostic (4.39e-3)" "unprognostic (3.81e-1)" "unprognostic (9.72e-2)" "unprognostic (1.92e-1)" "unprognostic (9.86e-2)" "unprognostic (1.24e-2)" "unprognostic (1.06e-1)" "unprognostic (4.24e-1)" "unprognostic (8.97e-3)" "unprognostic (1.84e-1)" "unprognostic (2.34e-1)" "prognostic favorable (4.29e-6)" "unprognostic (1.19e-1)" "unprognostic (8.59e-2)" "unprognostic (1.63e-1)" "unprognostic (4.47e-2)" 29.7 16.8 40.0 9.5 40.1 12.1 25.2 44.4 45.8 14.9 30.4 25.5 63.9 18.0 13.5 26.3 23.9 9.9 47.7 41.2 37.7 44.0 165.7 21.3 12.0 47.0 43.0 20.9 25.3 20.2 14.4 12.0 47.3 24.2 16.7 8.6 22.3 12.1 33.5 16.3 43.0 9.6 41.3 12.8 35.4 261.7 41.0 13.5 16.2 29.3 11.9 21.2 15.1 44.0 42.6 23.9 18.8 53.1 91.8 48.0 27.9 29.9 63.2 40.7 48.0 94.0 43.0 14.8 16.0 31.1 75.3 34.5 28.6 55.1 23.5 4.5 24.3 32.1 33.3 218.2 97.8 32.5 26.0 39.8 31.4 36.8 28.4 14.5 38.6 44.0 60.6 29.6 30.8 35.7 39.3 40.1 15.1 147.2 25.9 25.4 20.2 52.4 49.2 78.8 23.9 21.9 22.4 121.7 29.0 36.5 33.9 75.3 26.1 30.0 19.7 22.9 25.0 19.3 9.1 15.3 31.2 42.8 29.9 1.5 2.4 0.9 4.6 2.6 3.0 4.2 5.5 4.7 4.5 5.6 4.5 4.6 0.7 3.3 2.1 4.4 3.6 3.1 40.0 40.1 44.4 45.8 41.2 37.7 47.0 43.0 47.3 41.3 41.0 44.0 11.5 0.0 17.3 15.0 11.1 5.4 8.1 11.7 6.8 12.5 25.1 11.0 17.0 62.9 9.6 25.8 0.0 73.1 21.0 41.6 119.3 19.5 763.2 29.0 7.5 8.7 13.9 47.8 5.3 18.3 39.7 7.7 36.2 15.8 9.5 39.6 21.8 166.0 24.1 16.8 4.6 29.1 20.3 11.8 3.3 2829.0 27.7 8.1 33.8 0.0 14.7 26.7 22.6 3.5 12.2 17.8 18.8 25.9 13.4 11.4 144.4 130.3 29.4 10.6 26.3 6.2 11.5 253.1 18.1 16.5 5.7 50.8 13.6 34.4 48.7 7.7 PDF ENSG00000258429 "Peptide deformylase, mitochondrial" Q9HBH1 16 69326913-69330588 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Protein biosynthesis" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 27.8" "Cell type enhanced" "Detected in some" "Basal squamous epithelial cells: 8.0;Erythroid cells: 4.6;Gastric mucus-secreting cells: 8.6;Plasma cells: 14.7;Squamous epithelial cells: 17.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" HPA063409 Approved Approved Nucleoplasm,Mitochondria "Intracellular and membrane" No No "Cluster 24: B-cells - Unknown function" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 59: Non-specific - Transcription" Mitochondria Nucleoplasm "HPA063409: AB_2685007" "unprognostic (4.28e-2)" "prognostic unfavorable (4.63e-4)" "unprognostic (1.37e-1)" "unprognostic (1.47e-1)" "unprognostic (2.85e-1)" "prognostic unfavorable (2.73e-4)" "unprognostic (2.98e-3)" "prognostic unfavorable (7.35e-4)" "unprognostic (5.84e-2)" "unprognostic (4.35e-1)" "unprognostic (1.02e-1)" "unprognostic (1.00e-1)" "prognostic favorable (6.11e-4)" "unprognostic (4.78e-2)" "unprognostic (1.05e-1)" "unprognostic (5.98e-2)" "unprognostic (1.22e-2)" 5.9 8.7 1.0 0.9 1.3 1.4 5.5 1.9 1.8 4.4 1.5 5.6 2.1 5.8 0.4 10.2 4.7 0.5 5.3 2.2 0.8 19.0 27.8 4.4 1.1 1.4 0.8 3.1 8.8 1.6 4.3 0.6 1.0 5.0 0.8 0.3 7.2 0.6 12.4 7.7 5.2 0.4 0.8 5.1 5.6 4.8 0.9 0.6 5.9 0.8 0.7 4.8 4.8 1.5 6.3 4.8 1.3 4.1 1.1 0.8 7.7 6.0 1.0 2.9 2.4 8.6 5.7 13.1 6.2 1.6 2.2 11.5 1.8 2.1 1.3 3.5 23.3 6.6 5.3 12.6 1.8 10.8 5.7 1.7 4.3 2.5 1.2 0.8 1.5 7.2 16.1 2.4 1.9 7.6 9.2 8.3 6.4 2.6 7.1 20.8 2.1 11.0 2.2 5.4 9.3 7.1 10.8 2.9 5.2 0.3 11.0 3.3 4.6 3.9 6.4 5.8 6.8 12.1 9.4 15.2 3.1 6.9 5.9 1.4 0.7 1.0 0.4 0.3 0.9 1.2 1.0 1.2 0.6 4.1 1.5 0.7 0.0 0.4 0.4 1.3 0.9 0.3 1.0 1.3 1.9 1.8 2.2 0.8 1.4 0.8 1.0 0.8 0.9 1.5 0.2 3.2 0.0 0.0 3.0 0.0 0.1 0.0 8.0 0.0 0.3 0.1 0.4 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.0 0.5 0.3 0.6 0.0 4.6 0.0 0.2 0.3 1.2 8.6 0.5 0.0 0.2 0.4 0.8 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 14.7 0.1 0.4 1.1 0.0 0.0 0.0 0.1 0.8 0.2 0.1 17.7 0.4 0.3 1.4 0.1 0.0 0.1 PDIA2 "PDA2, PDI, PDIP, PDIR" ENSG00000185615 "Protein disulfide isomerase family A member 2" Q13087 16 283164-287215 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Chaperone, Isomerase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 13 "pancreas: 2509.7" "Cell type enriched" "Detected in some" 4 "Exocrine glandular cells: 294.9" "Cancer enriched" "Detected in many" 5 "pancreatic cancer: 28.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HAP1: 3.9;HEK 293: 7.9;Hep G2: 6.7;Karpas-707: 2.9;MCF7: 4.6;SH-SY5Y: 3.7" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA051692, HPA053492" Enhanced "Intracellular and membrane" NA NA "Cluster 25: Pancreas - Digestion" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 1: Pancreatic cells - Digestion" "HPA051692: AB_2681575, HPA053492: AB_2682169" "unprognostic (3.46e-2)" "unprognostic (7.98e-3)" "unprognostic (3.01e-2)" "unprognostic (1.30e-1)" "unprognostic (2.21e-1)" "unprognostic (2.17e-2)" "unprognostic (6.27e-3)" "unprognostic (1.11e-2)" "unprognostic (3.98e-1)" "unprognostic (1.76e-1)" "unprognostic (4.42e-2)" "unprognostic (2.90e-2)" "unprognostic (1.58e-14)" "unprognostic (3.06e-2)" "unprognostic (1.66e-1)" "unprognostic (8.75e-2)" "unprognostic (2.87e-2)" 2.8 0.6 64.4 0.4 70.1 0.6 0.8 80.5 96.0 0.6 61.2 2.7 23.9 0.3 0.9 0.9 0.7 0.1 4.4 64.2 66.7 0.6 0.6 0.7 0.2 76.6 67.1 1.5 2509.7 0.0 7.6 2.5 73.2 1.0 0.3 2.4 1.0 0.1 0.6 0.4 7.1 0.0 69.9 0.3 191.7 1.0 68.7 0.0 0.4 0.0 0.5 0.5 0.6 88.5 0.0 1.0 0.0 0.7 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.1 0.1 0.1 3.9 0.1 0.5 0.0 7.9 0.0 0.3 6.7 0.7 0.0 0.0 0.0 0.3 0.0 0.0 0.7 0.1 0.0 0.3 2.9 0.1 4.6 0.1 0.4 0.2 1.6 0.0 0.1 0.0 0.9 0.0 0.0 1.6 3.7 0.0 0.1 0.0 0.5 1.1 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.1 0.1 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 64.4 70.1 80.5 96.0 64.2 66.7 76.6 67.1 73.2 69.9 68.7 88.5 0.0 0.0 0.5 1.6 1.9 0.5 0.0 0.0 0.0 4.2 0.0 0.1 0.8 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.7 0.0 0.1 0.3 0.1 0.0 0.0 12.4 294.9 1.3 5.5 65.7 0.1 0.0 0.1 0.0 0.0 0.4 0.0 14.0 1.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 1.9 1.6 0.6 0.0 2.0 22.2 25.5 1.4 0.4 0.2 0.0 3.9 1.1 0.0 0.5 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.5 0.0 0.0 1.4 0.0 PDIA3 "ERp57, ERp60, ERp61, GRP57, GRP58, HsT17083, P58, PI-PLC" ENSG00000167004 "Protein disulfide isomerase family A member 3" P30101 15 43746410-43773278 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Isomerase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 1048.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002645, HPA003230, CAB011199, CAB015181, CAB075744" Enhanced Enhanced "Endoplasmic reticulum" "Intracellular and membrane" NA NA 200000000 "Cluster 44: Non-specific - Transcription" "Cluster 29: Non-specific - Vesicular transport" "Cluster 28: BEWO - Transcription regulation" "Cluster 55: Plasma cells - Humoral immune response" "Endoplasmic reticulum" "CAB011199: AB_609902, CAB015181: AB_2160857, CAB075744: AB_2665750, HPA002645: AB_1079031, HPA003230: AB_1079030" "unprognostic (9.20e-2)" "unprognostic (1.21e-3)" "unprognostic (1.34e-1)" "prognostic favorable (2.05e-4)" "unprognostic (2.40e-2)" "prognostic unfavorable (8.95e-5)" "unprognostic (1.67e-1)" "unprognostic (8.60e-2)" "unprognostic (2.65e-1)" "unprognostic (2.24e-1)" "unprognostic (1.84e-2)" "unprognostic (1.10e-1)" "prognostic unfavorable (2.11e-8)" "unprognostic (1.82e-1)" "unprognostic (1.73e-1)" "unprognostic (1.19e-1)" "unprognostic (6.63e-2)" 17.0 16.6 7.5 16.5 8.0 27.1 15.6 9.2 7.6 24.7 13.9 20.6 23.6 16.4 44.7 18.9 15.4 13.5 17.3 7.7 9.8 15.3 34.5 16.8 18.7 9.3 8.2 16.5 36.0 22.6 16.2 23.8 9.1 25.2 22.5 8.4 21.6 19.1 7.6 17.3 21.4 17.0 9.0 12.5 20.4 10.8 9.3 9.6 56.0 4.1 12.3 15.6 15.2 9.8 29.4 11.9 24.6 55.1 48.9 51.9 70.8 58.6 62.1 46.0 56.7 33.6 32.1 33.8 37.4 72.9 30.8 47.8 31.8 61.5 39.7 24.3 44.7 47.2 17.6 30.9 80.1 26.0 33.8 33.6 49.8 35.0 58.5 54.0 81.3 11.1 27.7 17.4 45.5 11.1 9.1 30.4 24.4 48.5 44.0 17.9 36.7 26.2 39.3 26.0 22.9 25.4 48.7 49.0 19.4 25.0 33.1 28.1 50.9 37.7 18.9 29.7 29.1 7.1 8.6 33.9 48.1 41.2 28.8 11.6 8.8 13.3 12.1 9.2 12.8 5.4 6.8 9.5 8.3 6.1 6.0 7.1 2.4 12.7 9.9 17.6 5.8 15.8 7.5 8.0 9.2 7.6 7.7 9.8 9.3 8.2 9.1 9.0 9.3 9.8 224.9 192.3 183.9 31.6 177.8 192.2 313.7 665.2 114.4 56.5 137.9 95.5 58.3 124.4 427.7 167.3 41.7 655.2 319.6 228.7 70.5 401.2 24.3 178.8 300.3 223.7 186.1 95.3 29.2 390.4 807.8 350.7 261.0 328.5 261.6 255.1 233.1 342.2 426.0 70.7 38.3 523.1 231.9 157.3 292.2 26.7 253.5 246.5 243.7 36.5 258.0 128.3 279.1 29.7 38.8 279.9 196.8 276.8 341.1 286.5 234.3 129.1 245.6 61.9 124.9 138.4 389.7 186.4 147.6 138.9 148.5 1048.8 237.8 390.8 335.4 291.7 PDIA4 "ERP70, ERP72" ENSG00000155660 "Protein disulfide isomerase family A member 4" P13667 7 149003062-149028662 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Isomerase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 386.7;Hepatocytes: 595.4;Plasma cells: 556.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006139, HPA006140, CAB017368" Supported Supported "Endoplasmic reticulum" "Intracellular and membrane" NA NA 15000000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 55: Plasma cells - Humoral immune response" "Endoplasmic reticulum" "CAB017368: AB_10621725, HPA006139: AB_1848256, HPA006140: AB_1848257" "unprognostic (1.98e-1)" "unprognostic (1.62e-2)" "unprognostic (1.77e-1)" "unprognostic (1.87e-2)" "prognostic unfavorable (9.69e-4)" "unprognostic (1.97e-2)" "unprognostic (1.81e-1)" "unprognostic (2.11e-2)" "unprognostic (5.11e-2)" "unprognostic (3.24e-3)" "unprognostic (6.08e-3)" "unprognostic (3.20e-2)" "prognostic unfavorable (5.20e-9)" "unprognostic (1.03e-1)" "unprognostic (1.53e-1)" "unprognostic (6.76e-2)" "unprognostic (2.51e-1)" 50.3 30.0 22.8 91.5 27.5 35.7 38.2 31.1 24.1 92.8 33.6 84.8 74.1 58.6 163.5 38.9 81.6 53.5 40.4 22.1 31.2 49.5 241.7 48.5 59.0 35.3 29.3 47.3 112.6 26.4 44.6 92.0 34.2 69.3 85.5 8.4 56.1 47.4 9.3 30.0 66.3 71.9 29.6 63.6 95.6 30.8 33.8 46.7 234.1 10.1 72.4 65.6 33.3 49.8 251.3 236.0 249.8 703.3 223.2 158.2 358.2 343.5 230.5 194.8 314.5 196.6 661.5 179.4 748.2 287.0 532.2 160.1 170.6 329.1 168.9 129.0 99.0 86.6 62.7 436.6 298.4 198.5 233.9 156.4 145.1 213.6 169.8 251.7 401.0 90.6 143.6 476.1 173.4 276.4 190.9 226.0 371.1 510.9 134.0 123.6 192.5 440.5 228.2 194.9 79.1 207.6 313.0 223.7 124.1 295.7 127.4 151.9 220.6 152.1 84.5 372.0 247.5 357.5 173.7 125.5 354.2 231.1 528.9 74.4 80.5 51.0 130.4 85.6 135.4 99.1 83.7 100.8 77.6 58.2 77.4 82.7 11.0 91.9 91.4 251.8 68.7 160.6 22.8 27.5 31.1 24.1 22.1 31.2 35.3 29.3 34.2 29.6 33.8 49.8 43.3 28.9 36.2 6.8 87.9 34.7 88.0 142.5 29.0 4.2 50.8 31.5 31.0 95.8 92.4 42.3 4.2 177.8 86.9 135.4 15.6 129.0 3.1 91.1 93.1 57.0 61.6 41.2 3.2 91.0 386.7 102.8 119.8 107.1 57.8 72.0 81.4 595.4 147.9 0.0 5.7 282.9 61.1 84.7 49.6 5.5 59.0 55.3 87.2 9.4 51.8 15.6 68.0 4.5 11.9 94.5 88.6 42.9 556.7 108.1 71.3 66.3 114.8 6.7 32.9 35.2 66.0 47.6 86.1 29.2 28.6 230.4 46.7 52.4 155.6 72.4 PDIA5 "FLJ30401, PDIR" ENSG00000065485 "Protein disulfide isomerase family A member 5" Q14554 3 123067025-123225227 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Isomerase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 80.2" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 133.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in single" "Immune cell enhanced" "Detected in many" "plasmacytoid DC: 12.8" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030353, HPA030355" Enhanced Supported "Nucleoplasm,Nucleoli fibrillar center,Golgi apparatus" "Intracellular and membrane" NA NA 4700000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 85: Liver - Metabolism" "Cluster 28: BEWO - Transcription regulation" "Cluster 38: Extravillous trophoblasts - Unknown function" "Nucleoplasm, Golgi apparatus" "Nucleoli fibrillar center" "HPA030353: AB_10599734, HPA030355: AB_10602200" "unprognostic (8.81e-2)" "unprognostic (2.25e-2)" "unprognostic (8.93e-2)" "prognostic favorable (4.55e-4)" "unprognostic (4.34e-2)" "unprognostic (2.10e-2)" "unprognostic (7.38e-2)" "unprognostic (2.41e-1)" "unprognostic (3.21e-2)" "unprognostic (4.02e-2)" "unprognostic (1.55e-1)" "unprognostic (2.26e-3)" "prognostic unfavorable (8.09e-11)" "unprognostic (1.57e-1)" "unprognostic (1.92e-1)" "unprognostic (1.06e-2)" "unprognostic (4.06e-3)" 17.9 23.6 0.3 15.2 0.3 17.9 13.8 0.2 1.4 14.5 2.7 20.1 13.9 12.4 30.2 6.1 14.0 19.6 9.9 0.6 0.8 14.5 80.2 17.7 11.1 0.5 0.6 11.5 26.6 10.7 12.7 47.4 0.4 32.3 25.0 4.2 13.7 7.9 4.2 8.8 12.8 17.0 0.3 10.1 33.4 15.3 0.9 4.5 30.8 4.3 12.0 17.9 9.5 0.7 24.0 14.6 17.7 21.5 80.3 71.9 95.0 44.9 74.5 24.5 66.9 47.8 21.6 0.0 57.6 69.9 15.7 12.5 7.8 27.4 25.7 1.1 8.8 10.4 3.9 56.7 33.2 26.5 1.4 62.3 40.2 16.6 34.5 26.1 84.0 10.1 13.6 60.4 16.9 29.6 7.2 31.3 13.1 54.5 15.6 6.7 13.0 67.5 20.7 13.9 19.3 11.4 22.0 24.0 40.4 28.7 21.4 32.3 47.2 6.2 19.5 29.4 12.3 18.1 5.0 10.8 20.2 21.0 21.5 0.0 9.3 0.3 1.4 2.4 2.3 3.5 1.0 0.8 5.5 1.1 0.6 0.6 0.2 0.5 0.5 12.8 0.0 2.3 0.3 0.3 0.2 1.4 0.6 0.8 0.5 0.6 0.4 0.3 0.9 0.7 17.2 19.2 30.7 2.6 5.6 5.0 6.0 6.4 3.4 13.1 6.9 4.7 2.7 35.8 11.3 5.5 39.6 41.8 3.1 5.4 0.0 32.2 1.6 5.4 13.1 24.3 8.4 5.5 9.6 28.6 133.6 20.7 30.5 21.1 3.8 7.3 37.5 50.1 12.1 0.0 7.1 36.9 0.0 7.8 5.5 2.0 24.2 4.4 8.8 5.6 5.0 2.3 0.0 1.0 2.5 11.9 7.6 22.2 40.1 18.1 3.5 5.3 6.4 28.4 13.1 3.6 17.6 1.3 1.5 3.4 4.1 50.2 3.1 23.3 15.1 4.5 PDIA6 "ERp5, P5, TXNDC7" ENSG00000143870 "Protein disulfide isomerase family A member 6" Q15084 2 10783391-10837977 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Chaperone, Isomerase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Extravillous trophoblasts: 1202.1;Plasma cells: 883.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034347, HPA034652, HPA034653" Enhanced Supported "Endoplasmic reticulum,Cytosol" "Intracellular and membrane" NA NA 15000000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 29: Non-specific - Vesicular transport" "Cluster 25: RPMI-8226 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" "Endoplasmic reticulum, Cytosol" "CAB034347: AB_2299360, HPA034652: AB_2674263, HPA034653: AB_10601982" "unprognostic (8.16e-2)" "prognostic unfavorable (1.80e-4)" "unprognostic (1.03e-1)" "unprognostic (1.24e-1)" "unprognostic (1.31e-1)" "prognostic unfavorable (1.20e-4)" "prognostic unfavorable (3.63e-5)" "unprognostic (3.17e-2)" "unprognostic (1.02e-2)" "unprognostic (5.25e-3)" "unprognostic (6.03e-3)" "unprognostic (1.68e-1)" "prognostic unfavorable (2.51e-6)" "unprognostic (6.59e-2)" "unprognostic (2.34e-1)" "unprognostic (1.38e-2)" "unprognostic (3.69e-3)" 118.3 112.3 54.5 155.8 64.6 140.8 124.9 57.1 66.7 178.8 71.2 156.0 122.4 131.6 418.5 98.2 133.5 96.7 113.4 55.9 60.8 130.3 260.5 103.8 118.1 61.1 55.4 99.8 252.1 149.7 74.0 171.3 60.7 127.4 171.6 48.0 184.1 135.5 59.3 64.3 121.5 155.5 60.9 107.4 155.4 55.1 62.6 86.6 363.3 59.4 153.7 130.9 75.7 66.4 287.0 304.6 425.7 672.6 535.6 459.4 753.4 677.8 625.9 348.3 465.1 435.1 548.5 460.9 464.7 668.9 674.1 228.0 324.1 568.3 371.1 363.2 253.4 374.2 228.4 713.2 577.5 387.9 268.9 334.2 428.4 338.1 603.3 642.1 798.0 171.8 328.0 963.6 348.7 338.8 150.5 400.8 356.6 923.4 236.4 355.7 433.0 846.4 498.3 339.9 272.0 543.2 267.6 387.0 396.2 547.8 136.8 648.5 395.0 324.4 409.8 296.3 399.1 900.0 596.6 297.1 438.5 479.6 464.8 276.1 200.0 95.5 198.4 210.9 219.0 197.6 154.2 187.6 215.0 161.0 74.3 125.1 35.0 241.6 161.4 268.9 174.4 319.2 54.5 64.6 57.1 66.7 55.9 60.8 61.1 55.4 60.7 60.9 62.6 66.4 217.1 57.7 124.2 17.6 193.9 103.0 294.2 552.8 61.5 69.1 121.1 91.7 35.9 148.7 264.6 196.8 29.2 456.3 164.6 125.8 43.0 338.6 8.2 146.5 382.9 176.2 157.7 89.2 47.4 240.6 1202.1 228.2 138.1 255.0 131.3 210.6 211.3 355.6 413.1 42.1 30.5 276.3 170.9 155.7 149.8 16.2 121.2 145.9 199.3 15.0 132.1 106.5 142.2 32.6 25.3 175.4 131.2 135.1 883.2 385.4 99.9 149.6 145.8 60.1 85.5 96.9 225.3 98.5 117.9 95.4 102.6 554.1 125.7 254.3 248.3 265.3 PDK1 ENSG00000152256 "Pyruvate dehydrogenase kinase 1" Q15118 2 172555373-172608669 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Glucose metabolism" "Kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 130.4;Plasma cells: 144.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in all" 5 "B-cells: 8.6;granulocytes: 25.2;T-cells: 21.2" "Cell line enhanced" "Detected in all" "U-266/70: 71.8;U-87 MG: 72.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017554, HPA027376" Approved NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 29: U-266 - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" "CAB017554: AB_2161138, HPA027376: AB_1855139" "unprognostic (2.14e-1)" "prognostic unfavorable (7.30e-5)" "unprognostic (1.21e-1)" "unprognostic (3.94e-2)" "unprognostic (6.47e-2)" "unprognostic (1.58e-1)" "unprognostic (1.02e-2)" "unprognostic (1.45e-1)" "unprognostic (9.69e-3)" "unprognostic (6.44e-2)" "unprognostic (5.44e-3)" "unprognostic (1.55e-1)" "prognostic unfavorable (1.10e-8)" "unprognostic (1.82e-1)" "unprognostic (1.94e-1)" "unprognostic (2.56e-2)" "unprognostic (5.34e-2)" 7.7 16.0 2.5 11.6 3.0 15.8 10.1 5.6 5.3 5.5 2.7 16.7 16.5 4.0 3.1 8.5 3.6 6.0 28.1 3.1 2.1 4.8 11.2 4.2 13.1 2.7 6.7 12.2 6.9 4.3 3.8 6.4 3.2 4.7 13.3 27.1 10.2 5.0 9.0 18.1 9.1 4.4 1.3 10.5 13.6 12.2 5.0 8.3 3.9 7.6 19.1 11.0 7.6 2.5 34.0 1.4 8.4 21.0 3.4 5.1 12.1 29.1 23.4 14.3 30.4 8.6 7.1 32.1 15.8 9.1 11.9 14.5 5.8 18.2 45.5 6.6 11.7 39.3 7.1 10.2 6.2 19.6 14.0 6.6 6.4 10.0 16.6 19.8 7.7 16.7 8.5 21.5 19.2 3.5 12.5 24.5 20.8 6.9 9.2 13.1 13.8 52.5 7.4 10.8 15.7 18.0 7.6 8.8 11.1 7.0 5.6 8.0 9.2 22.7 7.4 12.0 7.9 71.8 44.8 26.9 72.6 14.0 4.6 19.6 3.4 25.2 3.7 2.3 4.2 7.3 5.9 4.0 3.5 8.6 21.2 13.5 12.7 2.2 3.2 0.6 12.2 9.2 2.5 3.0 5.6 5.3 3.1 2.1 2.7 6.7 3.2 1.3 5.0 2.5 9.2 3.2 5.0 12.1 33.7 50.1 5.1 15.8 4.6 29.4 7.0 4.7 35.5 2.8 7.0 3.7 47.9 10.2 9.9 11.9 5.9 8.7 130.4 6.4 7.2 9.6 7.8 4.2 35.4 3.7 13.2 8.5 9.7 12.1 5.7 13.3 19.6 20.2 10.2 55.5 32.7 6.6 12.2 12.0 15.2 43.8 3.4 12.9 30.2 30.9 11.4 7.4 10.3 12.1 14.8 9.6 17.5 3.8 144.8 7.2 6.7 1.9 5.0 18.5 6.6 4.6 11.6 9.6 10.4 8.9 43.3 4.1 17.3 5.3 7.0 6.1 PDK2 PDHK2 ENSG00000005882 "Pyruvate dehydrogenase kinase 2" Q15119 17 50094737-50112152 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Glucose metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 216.2;tongue: 285.0" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 123.0;Proximal tubular cells: 131.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008287 Supported Approved Nucleoplasm,Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 80: Striated muscle - Unknown function" "Cluster 18: U-2197 - ECM organization" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nucleoplasm, Mitochondria" "HPA008287: AB_1079589" "unprognostic (2.74e-2)" "prognostic favorable (5.87e-4)" "unprognostic (1.16e-1)" "unprognostic (2.43e-3)" "unprognostic (1.22e-1)" "unprognostic (9.63e-3)" "unprognostic (9.80e-3)" "unprognostic (8.39e-3)" "unprognostic (3.19e-2)" "unprognostic (1.25e-1)" "unprognostic (1.17e-2)" "unprognostic (2.21e-1)" "prognostic favorable (9.59e-5)" "unprognostic (3.81e-1)" "unprognostic (2.54e-1)" "unprognostic (5.33e-1)" "unprognostic (1.55e-1)" 40.8 63.8 49.9 8.7 51.2 5.0 26.4 65.7 58.2 30.5 37.1 42.7 28.1 29.4 124.4 21.8 24.3 18.0 116.6 50.6 41.8 62.7 50.8 15.3 10.1 40.8 44.0 48.2 44.3 40.7 17.0 14.7 41.8 23.5 21.5 14.7 25.7 27.4 216.2 26.0 32.5 25.7 40.8 18.4 33.7 13.7 44.6 12.6 27.3 285.0 9.2 30.9 22.2 44.6 12.4 17.5 20.6 18.5 21.2 16.5 2.2 13.2 19.3 19.3 18.5 1.7 13.2 15.5 21.7 37.0 13.0 6.4 13.7 5.3 18.8 30.6 19.3 14.0 17.1 13.2 11.3 0.0 15.0 33.6 19.6 12.5 0.9 33.7 17.2 20.0 5.7 15.0 11.0 15.8 11.8 0.0 4.5 37.2 17.1 17.5 45.8 21.1 10.4 10.4 13.8 20.7 18.7 5.9 9.0 25.0 35.0 13.7 8.8 22.5 18.4 16.0 10.1 29.4 29.9 8.2 33.3 4.9 15.4 14.3 16.2 8.9 16.2 12.9 12.8 12.9 14.8 18.0 18.4 13.8 17.2 18.0 2.6 22.9 14.1 25.8 22.4 17.4 49.9 51.2 65.7 58.2 50.6 41.8 40.8 44.0 41.8 40.8 44.6 44.6 17.9 9.6 10.3 18.3 12.1 15.2 12.3 12.4 17.6 19.0 16.0 26.8 5.4 12.8 11.7 20.2 6.2 19.6 16.7 38.6 58.7 11.7 8.8 6.5 12.1 11.8 13.8 10.8 18.6 9.1 3.6 17.7 13.7 7.8 1.3 19.0 18.2 52.0 19.9 43.7 15.6 50.2 16.2 13.6 9.1 18.9 24.2 12.0 24.9 8.4 14.5 37.3 7.2 6.0 11.3 6.2 55.2 52.6 25.9 6.7 123.0 131.9 6.5 11.0 19.7 15.0 20.5 3.3 11.7 14.6 18.8 7.9 12.9 29.0 36.9 11.3 PDK3 ENSG00000067992 "Pyruvate dehydrogenase kinase 3" Q15120 X 24465270-24550466 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Carbohydrate metabolism, Glucose metabolism" "Kinase, Transferase" "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 71.6;Excitatory neurons: 92.8;Inhibitory neurons: 78.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046583, HPA072492" Approved Supported Nucleoli,Mitochondria NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 6: T47d - Mammary gland" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Mitochondria Nucleoli "HPA046583: AB_2679707, HPA072492: AB_2686526" "unprognostic (5.41e-3)" "unprognostic (5.43e-3)" "unprognostic (5.35e-3)" "unprognostic (3.40e-1)" "unprognostic (4.05e-3)" "unprognostic (5.38e-2)" "prognostic unfavorable (2.76e-4)" "unprognostic (1.51e-1)" "unprognostic (5.57e-2)" "unprognostic (1.35e-1)" "unprognostic (1.39e-2)" "unprognostic (2.02e-1)" "unprognostic (1.72e-1)" "unprognostic (1.02e-1)" "unprognostic (2.92e-1)" "unprognostic (2.28e-2)" "unprognostic (9.43e-3)" 4.4 2.0 4.4 5.6 6.2 8.9 8.8 1.4 7.5 3.5 2.5 6.1 8.2 2.8 10.9 3.9 5.9 3.2 7.4 13.2 4.7 8.8 4.7 5.0 7.9 2.6 4.2 4.8 2.9 6.7 5.8 4.1 2.4 4.6 5.3 6.0 11.1 2.9 1.4 6.8 8.3 4.5 0.9 7.7 6.9 11.6 9.1 6.3 2.3 1.8 8.0 4.2 4.1 4.2 11.5 5.2 4.2 8.0 0.2 0.0 5.0 3.4 2.4 4.1 6.9 0.5 13.9 10.4 2.3 0.8 11.6 2.1 12.3 8.4 10.4 9.7 6.0 5.3 6.1 3.3 1.4 4.6 5.8 0.9 3.6 1.1 1.2 0.5 6.8 10.9 0.9 16.5 0.5 20.9 9.4 6.0 8.1 12.2 5.6 5.0 8.0 17.3 4.1 21.4 2.6 4.0 17.9 8.0 5.5 7.3 9.6 1.9 0.1 3.3 3.6 5.8 4.2 11.0 8.9 12.9 8.7 7.7 6.4 13.3 15.4 37.9 11.8 19.6 16.5 7.5 9.1 10.3 12.2 7.3 7.6 8.6 57.6 13.3 18.8 3.5 8.3 12.4 4.4 6.2 1.4 7.5 13.2 4.7 2.6 4.2 2.4 0.9 9.1 4.2 3.9 3.2 2.0 19.6 15.2 4.6 9.5 13.5 30.1 3.5 11.1 8.1 6.6 1.5 5.2 1.8 0.0 5.5 16.6 4.2 3.9 4.3 71.6 2.1 2.9 3.8 4.2 14.3 92.8 5.1 32.1 4.9 5.6 2.8 5.7 4.9 5.3 5.3 15.0 8.4 78.0 2.9 10.2 19.8 7.4 35.9 3.7 17.4 16.0 35.6 10.3 3.7 25.7 19.6 14.0 2.1 0.3 5.7 19.0 5.9 13.3 14.2 2.4 3.5 0.0 2.0 10.6 10.2 8.3 6.8 4.4 17.8 18.2 9.7 4.1 8.4 PDK4 ENSG00000004799 "Pyruvate dehydrogenase kinase 4" Q16654 7 95583499-95596516 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Glucose metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 2300.1;tongue: 1216.5" "Cell type enhanced" "Detected in many" "Adipocytes: 681.3;Cardiomyocytes: 764.5;Kupffer cells: 464.0;Proximal enterocytes: 654.2;Smooth muscle cells: 489.7" "Cancer enhanced" "Detected in all" "renal cancer: 107.8;thyroid cancer: 89.5" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 12 "classical monocyte: 32.5;eosinophil: 38.1;intermediate monocyte: 63.5;myeloid DC: 16.8;non-classical monocyte: 39.8" "Group enriched" "Detected in many" 12 "dendritic cells: 16.8;granulocytes: 38.1;monocytes: 63.5" "Cell line enriched" "Detected in many" 7 "ASC diff: 482.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056731 Approved NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "HPA056731: AB_2683218" "unprognostic (3.18e-3)" "unprognostic (1.98e-1)" "unprognostic (1.52e-1)" "unprognostic (1.34e-1)" "unprognostic (5.15e-2)" "unprognostic (1.32e-1)" "unprognostic (1.00e-3)" "unprognostic (3.47e-1)" "unprognostic (6.38e-2)" "unprognostic (2.24e-3)" "unprognostic (1.87e-2)" "unprognostic (8.75e-2)" "unprognostic (2.41e-2)" "prognostic unfavorable (1.80e-4)" "unprognostic (9.15e-2)" "unprognostic (4.20e-2)" "unprognostic (1.12e-1)" 451.2 216.3 32.4 33.4 48.0 2.5 388.7 32.9 43.0 76.3 222.0 278.9 72.3 89.0 10.4 151.5 153.5 80.6 480.4 40.0 35.3 127.8 223.4 120.4 24.0 44.5 41.8 240.8 549.3 18.2 39.9 104.8 45.3 91.2 42.6 2.0 60.2 529.5 2300.1 91.9 163.3 62.2 34.8 99.0 173.1 13.3 39.8 13.8 72.1 1216.5 13.5 187.5 95.2 59.4 0.0 37.7 1.5 9.5 482.2 0.8 0.4 0.0 0.0 0.0 0.0 0.0 12.8 0.0 5.3 1.7 1.6 0.0 0.1 0.0 0.0 0.0 1.3 0.2 66.8 0.0 4.5 0.0 0.0 5.3 0.0 0.0 0.0 0.2 2.4 0.0 1.7 0.0 0.2 0.9 0.0 0.4 0.1 0.0 2.1 0.0 0.0 0.3 23.5 2.6 0.5 2.7 0.0 3.0 8.6 2.4 1.3 1.1 0.0 0.0 0.8 2.1 0.1 0.0 0.0 0.1 1.5 0.0 0.0 0.3 32.5 38.1 0.0 63.5 0.1 0.4 0.0 0.0 16.8 1.5 0.0 0.0 2.5 3.3 39.8 0.5 0.0 14.2 32.4 48.0 32.9 43.0 40.0 35.3 44.5 41.8 45.3 34.8 39.8 59.4 681.3 32.1 16.0 154.4 6.0 10.5 279.2 9.2 19.9 0.1 95.9 40.6 764.5 30.0 36.1 378.9 0.0 5.9 3.9 67.7 13.7 7.2 14.9 151.0 52.1 108.0 55.4 9.3 0.4 5.5 0.7 326.9 158.5 347.5 5.1 19.9 199.2 130.5 49.8 0.0 1.2 96.0 6.1 464.0 21.5 6.7 134.2 204.8 90.7 19.7 19.8 8.4 1.0 7.1 26.2 6.2 46.3 44.8 6.4 110.0 654.2 74.2 66.3 0.4 164.3 293.2 489.7 1.8 1.0 12.3 9.2 10.9 5.3 18.7 60.5 157.4 PDP1 "PDH, PDP, PPM2A, PPM2C" ENSG00000164951 "Pyruvate dehyrogenase phosphatase catalytic subunit 1" Q9P0J1 8 93857807-93926068 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 80.0;Early spermatids: 144.2" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in many" 8 "amygdala: 14.2;basal ganglia: 20.1;cerebral cortex: 41.7;hippocampal formation: 23.4;white matter: 18.5" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "GAMG: 117.8;hTERT-RPE1: 117.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018483, HPA019081, HPA021152" Uncertain Approved Nucleoplasm,Mitochondria,Cytosol Yes No "Cluster 27: Non-specific - Gene expression" "Cluster 8: Non-specific - Mitochondria" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 29: Early spermatids - Spermatogenesis" "Nucleoplasm, Mitochondria, Cytosol" "HPA018483: AB_1855634, HPA019081: AB_1855633, HPA021152: AB_1855635" "prognostic unfavorable (8.61e-5)" "unprognostic (4.62e-1)" "unprognostic (8.79e-2)" "unprognostic (1.09e-1)" "unprognostic (9.46e-2)" "unprognostic (1.38e-1)" "unprognostic (1.59e-1)" "unprognostic (1.18e-2)" "unprognostic (1.00e-1)" "prognostic unfavorable (5.60e-4)" "unprognostic (1.71e-2)" "unprognostic (3.25e-1)" "prognostic favorable (8.42e-9)" "unprognostic (1.85e-1)" "unprognostic (1.84e-1)" "unprognostic (5.04e-2)" "unprognostic (1.67e-1)" 10.6 62.6 14.2 10.5 20.1 14.4 16.1 0.0 41.7 14.2 1.2 8.9 7.2 15.5 17.0 14.2 12.2 19.4 49.2 23.4 0.0 12.8 4.2 12.6 12.9 0.0 2.3 19.3 19.9 29.9 5.4 13.8 0.0 10.3 12.4 14.1 11.7 9.4 72.9 4.3 7.6 11.2 0.0 13.2 11.7 26.7 3.0 11.6 18.8 16.9 12.4 14.0 6.8 18.5 25.7 12.0 25.9 10.9 21.0 37.9 8.6 19.3 21.7 22.1 25.8 12.7 90.3 13.9 63.8 30.8 117.8 54.4 11.0 16.1 32.8 1.5 5.6 6.6 15.7 4.5 23.9 3.3 9.0 24.5 31.5 37.7 59.8 117.1 50.9 12.4 2.4 22.8 27.6 6.0 20.3 10.3 12.1 26.8 15.4 4.8 15.5 2.6 15.3 17.0 2.4 11.4 12.7 1.4 61.8 20.9 4.0 3.9 90.9 27.5 17.2 63.8 23.3 12.6 5.8 12.1 34.2 11.7 25.1 6.4 27.9 14.5 9.2 25.3 8.9 15.6 15.1 12.0 22.5 17.9 8.9 7.8 3.1 5.4 41.1 3.7 34.9 18.0 14.2 20.1 0.0 41.7 23.4 0.0 0.0 2.3 0.0 0.0 3.0 18.5 10.7 12.8 7.8 15.0 18.0 13.0 12.7 36.3 68.9 38.3 11.6 7.0 80.0 14.3 35.6 16.5 8.4 4.3 13.7 27.5 5.9 33.3 144.2 33.3 14.9 15.0 10.2 1.3 73.6 14.0 3.9 20.8 16.3 70.2 6.3 3.7 12.5 3.3 6.3 10.1 23.4 5.5 10.2 19.2 19.1 28.1 11.5 19.9 10.6 19.7 22.4 18.8 10.3 13.0 8.5 24.5 9.6 13.5 8.1 15.6 4.9 11.4 30.5 11.5 6.6 35.4 13.1 10.1 11.4 26.5 10.9 4.4 19.3 7.1 10.7 23.9 PDP2 "KIAA1348, PPM2B, PPM2C2" ENSG00000172840 "Pyruvate dehyrogenase phosphatase catalytic subunit 2" Q9P2J9 16 66878589-66895754 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 22.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019950, HPA062059" Approved Approved Mitochondria NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 7: Kidney - Transmembrane transport" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 11: Alveolar cells - Smell perception" Mitochondria "HPA019950: AB_1855156, HPA062059: AB_2684671" "unprognostic (8.42e-2)" "unprognostic (1.09e-1)" "unprognostic (1.19e-2)" "unprognostic (1.31e-1)" "unprognostic (2.31e-2)" "unprognostic (5.44e-2)" "unprognostic (1.17e-1)" "unprognostic (4.90e-3)" "unprognostic (1.57e-1)" "unprognostic (7.24e-2)" "unprognostic (1.03e-1)" "unprognostic (1.39e-1)" "prognostic favorable (9.75e-7)" "unprognostic (1.89e-1)" "unprognostic (5.10e-1)" "unprognostic (3.20e-1)" "unprognostic (6.15e-2)" 6.0 2.6 3.6 1.8 4.6 1.5 3.6 6.9 5.2 2.0 7.7 3.8 5.4 2.6 3.4 3.7 3.4 2.0 1.8 3.6 4.3 9.2 8.6 3.4 2.6 6.2 4.6 7.4 4.5 6.1 3.0 4.0 6.8 3.8 4.1 5.0 3.6 2.6 2.5 2.1 3.2 2.1 3.5 2.0 3.0 3.8 5.7 2.5 9.3 4.1 3.0 2.1 2.2 4.3 9.8 11.7 7.1 14.1 18.7 9.6 8.9 5.0 19.2 11.3 17.0 23.9 6.7 13.5 6.9 6.9 10.8 12.1 20.8 11.3 10.9 3.2 10.5 6.8 5.9 15.9 10.1 8.8 11.5 7.4 8.3 16.1 16.6 12.3 4.9 14.9 13.3 9.5 10.3 6.3 17.1 6.2 8.4 6.5 14.7 16.7 9.9 21.4 6.0 10.3 14.3 8.0 15.9 6.5 6.0 5.5 8.7 4.3 4.6 7.0 9.2 4.2 7.5 16.6 16.9 13.4 9.5 6.9 7.0 1.1 0.2 1.2 3.8 0.1 3.1 1.0 1.8 3.2 0.8 2.1 2.6 3.0 0.7 4.2 0.1 0.5 0.6 1.3 3.6 4.6 6.9 5.2 3.6 4.3 6.2 4.6 6.8 3.5 5.7 4.3 2.5 9.6 22.9 8.1 3.1 5.2 6.4 1.3 6.2 9.6 5.8 4.2 5.1 8.6 3.1 9.2 14.6 12.8 3.3 13.3 7.9 3.4 0.2 3.5 3.2 3.3 3.6 0.8 8.8 2.9 2.2 4.1 3.1 4.3 6.3 14.4 7.1 20.5 2.4 5.0 7.6 4.2 2.0 1.3 0.4 2.4 3.1 1.2 3.6 3.7 0.4 8.1 7.2 4.5 4.3 3.4 6.6 4.5 4.5 8.9 7.4 9.9 1.2 6.7 0.0 5.9 2.7 12.6 5.7 8.0 2.4 3.6 3.4 4.0 5.5 6.5 PDPK1 PDK1 ENSG00000140992 "3-phosphoinositide dependent protein kinase 1" O15530 16 2537979-2603188 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004272, HPA035199" Supported Supported Cytosol NA NA "Cluster 34: Basophils - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 44: HDLM-2 - Immune response" "Cluster 41: Macrophages - Immune response" Cytosol "CAB004272: AB_626657, HPA035199: AB_2674514" "unprognostic (2.67e-2)" "unprognostic (1.63e-1)" "unprognostic (3.12e-3)" "unprognostic (4.21e-2)" "unprognostic (1.34e-1)" "unprognostic (4.69e-3)" "unprognostic (8.37e-2)" "unprognostic (3.18e-2)" "unprognostic (8.17e-2)" "unprognostic (3.70e-2)" "unprognostic (1.52e-2)" "unprognostic (3.28e-2)" "prognostic favorable (1.29e-14)" "unprognostic (2.04e-2)" "unprognostic (5.96e-2)" "unprognostic (1.95e-1)" "unprognostic (2.16e-1)" 11.6 13.5 15.1 12.4 25.2 16.1 11.1 10.2 20.6 10.9 1.5 15.8 17.3 11.8 13.2 13.3 14.7 9.5 15.1 19.2 5.2 17.0 12.4 13.6 15.0 10.8 6.1 14.0 19.4 27.1 11.2 12.1 11.3 13.0 14.9 15.5 17.8 12.2 18.9 14.2 19.6 12.3 3.7 13.9 13.6 14.7 7.7 16.8 15.8 19.2 14.1 11.1 10.4 12.5 13.1 16.5 20.1 13.5 20.3 16.9 21.5 21.7 13.6 18.7 15.6 16.6 15.2 21.4 14.5 20.7 15.9 20.2 24.3 15.3 17.6 39.6 17.1 11.4 23.0 27.7 17.7 19.2 29.0 15.4 27.5 20.1 13.3 17.9 17.3 19.1 22.2 17.0 22.1 27.7 19.2 13.3 12.8 24.3 15.1 39.0 20.2 19.5 18.0 11.5 31.7 16.3 27.9 31.3 11.5 12.8 29.0 23.5 21.6 20.2 20.2 20.0 18.8 22.6 23.4 33.3 9.7 13.1 17.9 5.4 7.1 8.4 4.1 8.3 3.9 4.2 3.8 5.0 5.8 3.4 4.3 4.0 12.5 5.2 8.9 8.0 1.9 4.7 15.1 25.2 10.2 20.6 19.2 5.2 10.8 6.1 11.3 3.7 7.7 12.5 17.6 16.0 19.1 45.1 32.9 26.6 20.8 25.7 26.7 60.2 30.0 22.0 33.8 40.0 23.0 11.0 54.2 47.0 35.2 41.1 13.7 23.1 14.4 35.6 23.8 19.1 21.6 28.0 46.7 23.6 27.9 23.2 23.0 45.3 7.6 18.1 22.5 46.1 26.0 74.0 41.7 29.9 10.2 55.7 51.1 30.4 31.7 37.1 21.4 31.9 43.3 42.3 25.7 37.7 44.2 31.6 24.0 44.4 27.1 30.3 50.2 44.8 41.1 44.9 46.0 30.5 30.0 46.8 36.8 38.5 34.1 104.7 25.7 24.2 31.4 27.1 PGAM5 "BXLBv68, MGC5352" ENSG00000247077 "PGAM family member 5, mitochondrial serine/threonine protein phosphatase" Q96HS1 12 132710819-132722734 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Necrosis Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036978, HPA036979, CAB068215" Enhanced Supported Mitochondria "Intracellular and membrane" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "CAB068215: AB_2665674, HPA036978: AB_10964347, HPA036979: AB_10960559" "unprognostic (9.57e-2)" "unprognostic (2.00e-2)" "unprognostic (3.83e-2)" "unprognostic (3.11e-2)" "unprognostic (3.46e-1)" "unprognostic (1.39e-1)" "prognostic unfavorable (1.13e-6)" "unprognostic (3.32e-2)" "unprognostic (1.47e-1)" "unprognostic (5.67e-2)" "unprognostic (1.23e-1)" "unprognostic (6.92e-2)" "unprognostic (6.42e-3)" "unprognostic (1.63e-2)" "unprognostic (1.71e-1)" "unprognostic (1.19e-1)" "unprognostic (5.53e-2)" 10.5 17.7 13.0 17.0 12.7 16.3 9.7 12.7 17.0 9.8 10.1 16.1 15.2 10.9 6.6 23.9 12.4 8.7 20.0 19.0 12.5 14.3 28.9 9.3 21.2 9.3 9.7 7.2 25.8 10.7 9.9 10.7 10.1 9.4 11.3 6.0 15.5 11.5 33.2 17.1 13.2 11.3 7.9 12.8 13.3 16.5 10.8 14.8 11.6 19.0 16.1 15.6 11.8 11.3 72.2 134.3 28.2 79.5 19.4 15.6 66.1 37.4 22.0 59.1 33.0 168.6 40.2 92.3 67.2 31.2 30.4 61.2 132.9 67.5 24.1 47.3 106.7 110.7 61.6 89.2 44.0 105.8 61.8 19.4 48.8 69.0 73.6 19.3 43.6 73.4 143.3 36.9 23.5 128.5 144.5 105.7 108.0 61.8 94.4 109.4 31.2 73.3 38.4 97.4 102.8 58.0 62.2 86.1 38.9 22.2 108.9 57.5 38.2 29.9 65.5 60.6 89.9 77.2 124.8 133.5 38.8 85.3 51.1 4.9 1.1 0.3 1.1 1.2 1.8 1.7 1.3 1.3 1.0 1.7 1.3 1.7 0.9 1.6 1.7 3.3 1.1 0.8 13.0 12.7 12.7 17.0 19.0 12.5 9.3 9.7 10.1 7.9 10.8 11.3 6.6 3.2 6.1 3.9 8.9 11.5 16.7 2.6 2.2 9.5 7.8 5.5 15.1 15.7 1.5 5.5 14.6 7.6 11.9 11.7 5.9 5.8 14.5 6.3 6.3 7.0 13.1 5.0 5.1 7.9 14.4 4.9 4.1 9.3 0.0 7.1 5.7 22.4 7.3 6.7 3.9 8.9 2.0 6.9 5.8 20.6 5.9 4.7 3.6 1.9 5.3 4.4 3.1 2.0 2.3 7.5 6.9 6.8 9.7 19.5 5.2 11.5 4.5 12.9 6.6 8.0 6.4 15.1 10.1 10.8 17.3 6.2 7.4 9.2 15.7 16.1 PGLYRP1 "PGLYRP, PGRP, PGRP-S, PGRPS, TAG7, TNFSF3L" ENSG00000008438 "Peptidoglycan recognition protein 1" O75594 19 46019153-46023053 "Metabolic proteins, Plasma proteins, Predicted secreted proteins" "Immunity, Innate immunity" "Antibiotic, Antimicrobial" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 15 "bone marrow: 629.4" "Cell type enhanced" "Detected in some" "Erythroid cells: 3.2;Excitatory neurons: 1.7;Inhibitory neurons: 1.5" "Not detected" "Not detected" "Region enhanced" "Detected in some" "cerebellum: 3.4" "Group enriched" "Detected in some" 202 "eosinophil: 443.7;neutrophil: 494.6" "Lineage enriched" "Detected in many" 213 "granulocytes: 494.6" "Cell line enhanced" "Detected in some" "A549: 3.1;HEK 293: 1.8;HeLa: 1.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045702, HPA070227" Enhanced Approved Nucleoplasm,Vesicles,Cytosol "Secreted to blood" NA NA 35000000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 6: Erythroid cells - Oxygen transport" Vesicles "Nucleoplasm, Cytosol" "HPA045702: AB_10960204, HPA070227: " "unprognostic (2.87e-2)" "unprognostic (4.26e-1)" "unprognostic (1.32e-1)" "unprognostic (3.04e-1)" "unprognostic (1.58e-1)" "unprognostic (4.93e-3)" "unprognostic (2.20e-1)" "unprognostic (6.46e-2)" "unprognostic (7.77e-2)" "unprognostic (2.61e-2)" "unprognostic (8.51e-3)" "unprognostic (7.18e-2)" "unprognostic (2.04e-2)" "unprognostic (2.96e-1)" "unprognostic (1.03e-1)" "unprognostic (1.73e-1)" "unprognostic (4.37e-3)" 1.5 0.3 0.3 1.8 1.1 629.4 0.3 3.4 1.5 0.1 0.0 0.3 0.6 0.2 0.0 0.5 0.6 0.2 1.7 0.6 0.0 0.8 2.5 8.7 0.5 0.0 0.1 0.1 0.5 0.0 0.7 0.9 0.0 0.2 0.0 0.0 0.5 0.0 0.3 1.0 0.7 0.1 0.0 42.5 0.4 1.0 0.0 3.3 0.5 2.3 0.0 0.4 0.2 0.0 0.3 3.1 0.5 0.3 0.0 0.0 0.9 0.3 0.0 0.0 0.0 0.5 0.2 0.8 0.1 0.0 0.2 1.2 0.0 0.0 0.0 0.8 1.8 0.3 1.7 0.1 0.0 0.2 0.9 0.0 0.0 0.0 0.0 0.1 0.0 0.7 0.3 0.3 0.0 0.2 0.2 0.9 0.2 0.0 1.2 0.7 0.1 0.0 0.0 1.2 0.3 0.0 0.2 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.1 0.3 0.4 0.7 0.6 0.3 0.4 0.7 0.0 0.2 0.4 443.7 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 494.6 0.0 2.3 0.0 0.1 3.9 0.3 1.1 3.4 1.5 0.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 3.2 1.7 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 1.5 0.0 0.0 0.3 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 PGLYRP2 "PGLYRPL, PGRP-L, PGRPL, tagL, tagL-alpha, tagl-beta, TAGL-like" ENSG00000161031 "Peptidoglycan recognition protein 2" Q96PD5 19 15468645-15498956 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins" Immunity Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 45 "liver: 258.8" "Cell type enriched" "Detected in some" 11 "Hepatocytes: 168.7" "Cancer enriched" "Detected in some" 16 "liver cancer: 42.9" "Not detected" "Not detected" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in many" 7 "granulocytes: 3.4;monocytes: 5.1;T-cells: 2.3" "Group enriched" "Detected in some" 5 "MCF7: 8.1;T-47d: 8.4" "Not detected" "Not detected" "Not detected" "Not detected" "CAB033468, HPA046311, HPA075237" Supported Approved "Cell Junctions" "Secreted to blood" NA NA 87000000000 "Cluster 51: Monocytes - Innate immune response" "Cluster 62: Liver - Hemostasis" "Cluster 6: T47d - Mammary gland" "Cluster 2: Hepatocytes - Metabolism" "Cell Junctions" "CAB033468: AB_1127187, HPA046311: AB_2679621, HPA075237: AB_2686739" "unprognostic (7.39e-3)" "unprognostic (1.52e-2)" "unprognostic (5.22e-2)" "unprognostic (8.79e-2)" "unprognostic (3.97e-1)" "unprognostic (4.88e-4)" "unprognostic (5.93e-3)" "unprognostic (6.48e-2)" "unprognostic (1.99e-1)" "unprognostic (1.18e-2)" "unprognostic (3.15e-2)" "unprognostic (2.40e-1)" "unprognostic (6.66e-16)" "unprognostic (6.35e-3)" "unprognostic (2.80e-1)" "unprognostic (2.45e-2)" "unprognostic (2.81e-4)" 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.1 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 258.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.1 0.1 5.7 0.0 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 8.1 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.1 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 8.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 3.4 0.4 0.2 1.6 1.7 1.6 0.2 0.9 0.8 0.1 0.0 2.2 2.3 1.6 0.5 5.1 0.0 0.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 4.3 0.0 0.2 0.5 0.0 0.0 4.1 1.5 0.2 4.3 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 3.3 0.0 0.0 0.3 0.0 0.4 0.4 0.0 0.1 0.1 0.0 0.0 0.0 0.0 2.9 168.7 0.3 0.0 0.4 0.0 0.0 2.2 0.0 3.1 0.3 1.9 8.8 0.0 1.0 0.0 1.0 0.0 0.2 0.0 0.0 0.0 14.1 0.8 0.0 0.2 0.0 0.0 0.0 0.1 0.2 0.4 0.7 0.1 0.1 0.0 7.6 0.0 0.0 0.1 PGLYRP3 "PGLYRPIalpha, PGRP-Ialpha, PGRPIA" ENSG00000159527 "Peptidoglycan recognition protein 3" Q96LB9 1 153297862-153310718 "Metabolic proteins, Predicted secreted proteins" "Immunity, Innate immunity" "Antibiotic, Antimicrobial" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "esophagus: 38.9;skin 1: 73.7;vagina: 21.4" "Cell type enriched" "Detected in single" 12 "Squamous epithelial cells: 4.9" "Cancer enhanced" "Detected in many" "cervical cancer: 8.9;head and neck cancer: 16.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 15 "HaCaT: 3.8;HDLM-2: 1.6;hTCEpi: 1.4" "Not detected" "Not detected" "Not detected" "Not detected" HPA030369 Uncertain "Secreted in other tissues" NA NA "Cluster 31: Skin - Epidermis development" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 61: Squamous epithelial cells - Keratinization" "HPA030369: AB_10603984" "unprognostic (6.34e-2)" "unprognostic (1.60e-1)" "unprognostic (7.09e-2)" "unprognostic (2.24e-2)" "unprognostic (2.46e-1)" "unprognostic (5.42e-2)" "unprognostic (3.88e-3)" "unprognostic (1.28e-1)" "unprognostic (1.82e-1)" "unprognostic (2.25e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 12.4 0.0 0.0 0.0 0.0 0.0 38.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.1 0.0 0.1 73.7 0.0 0.0 0.1 0.0 0.1 0.1 0.1 0.3 0.0 0.0 7.6 0.0 21.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.8 0.0 0.0 0.0 1.6 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.9 0.4 0.0 0.0 0.0 0.0 0.0 PGLYRP4 "PGLYRPIbeta, PGRP-Ibeta, PGRPIB, SBBI67" ENSG00000163218 "Peptidoglycan recognition protein 4" Q96LB8 1 153330120-153348841 "Metabolic proteins, Predicted secreted proteins" "Immunity, Innate immunity" "Antibiotic, Antimicrobial" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "cervix: 8.5;esophagus: 8.2;skin 1: 15.1;vagina: 10.3" "Group enriched" "Detected in some" 4 "Basal respiratory cells: 30.1;Club cells: 9.7" "Cancer enhanced" "Detected in some" "head and neck cancer: 7.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HaCaT: 3.7;HDLM-2: 2.2;Karpas-707: 1.8" "Not detected" "Not detected" "Low region specificity" "Detected in some" CAB025879 Approved "Vesicles,Plasma membrane" "Secreted in other tissues" NA NA "Cluster 31: Skin - Epidermis development" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Vesicles, Plasma membrane" "CAB025879: " "unprognostic (2.76e-2)" "unprognostic (1.19e-1)" "unprognostic (6.10e-2)" "unprognostic (1.34e-2)" "unprognostic (3.61e-3)" "unprognostic (1.46e-1)" "unprognostic (3.13e-1)" "unprognostic (5.42e-2)" "unprognostic (3.99e-2)" "unprognostic (1.07e-2)" "unprognostic (2.15e-1)" "unprognostic (1.81e-1)" "unprognostic (1.88e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 8.5 0.0 0.0 0.0 0.0 0.0 8.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 1.4 0.0 0.0 15.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.0 2.3 0.0 10.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.7 0.0 0.0 0.0 2.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.4 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.1 30.1 0.6 0.0 0.0 0.1 0.3 0.0 9.7 0.0 0.0 0.0 0.0 0.1 0.0 1.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.2 2.0 0.0 0.3 0.3 0.3 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.4 0.0 2.4 0.0 0.0 0.0 0.3 0.0 0.0 4.0 3.4 0.3 0.0 0.0 0.2 0.2 PGP ENSG00000184207 "Phosphoglycolate phosphatase" A6NDG6 16 2211593-2214840 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 52.2" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 404.5;Early spermatids: 480.5;Late spermatids: 1591.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043096, HPA046739" Approved Approved "Nuclear bodies" NA NA 250000 "Cluster 52: Eosinophils - Transcription" "Cluster 43: Testis - Unknown function" "Cluster 20: HeLa - Mitochondria" "Cluster 31: Spermatids - Spermatogenesis" "Nuclear bodies" "HPA043096: AB_2678311, HPA046739: AB_2679779" "unprognostic (8.33e-2)" "unprognostic (4.77e-3)" "unprognostic (2.36e-2)" "unprognostic (7.23e-2)" "unprognostic (2.12e-3)" "unprognostic (1.76e-1)" "unprognostic (5.75e-3)" "unprognostic (5.87e-2)" "unprognostic (7.90e-2)" "unprognostic (4.43e-3)" "unprognostic (6.50e-2)" "unprognostic (9.04e-2)" "prognostic favorable (7.05e-4)" "unprognostic (1.28e-1)" "unprognostic (2.63e-1)" "unprognostic (1.11e-1)" "prognostic favorable (6.42e-4)" 7.5 11.8 17.3 6.1 17.6 8.3 7.6 19.5 26.9 6.4 10.6 11.2 6.0 8.7 4.7 6.9 7.2 3.2 33.0 16.3 13.3 14.0 11.5 10.0 6.4 26.8 15.2 4.7 7.8 5.6 11.9 5.3 27.6 8.3 3.8 7.8 7.3 4.8 41.1 7.8 11.5 3.4 12.6 13.7 10.3 52.2 15.7 5.5 16.1 18.0 3.8 8.6 5.4 17.8 16.2 26.0 18.9 17.5 7.3 6.1 35.4 18.5 8.6 16.5 17.0 40.3 20.0 12.3 17.7 8.5 13.5 26.7 12.7 15.7 7.4 17.0 35.3 12.4 44.3 18.4 4.9 21.8 19.6 6.8 7.0 15.6 5.7 6.3 10.9 20.0 22.4 12.7 9.3 44.1 25.1 35.7 24.1 9.8 23.9 40.9 16.3 27.5 13.9 10.1 24.1 14.8 16.8 29.8 13.1 13.4 22.9 25.3 10.9 17.6 22.5 15.9 18.7 30.1 13.9 17.8 5.8 19.2 13.7 0.0 0.8 2.5 0.7 1.2 0.1 0.2 0.4 0.5 0.5 0.8 0.2 0.4 0.6 0.1 1.2 0.7 0.5 0.2 17.3 17.6 19.5 26.9 16.3 13.3 26.8 15.2 27.6 12.6 15.7 17.8 35.0 6.4 7.8 17.6 20.9 23.3 7.8 2.6 4.0 196.1 31.1 33.8 40.7 17.2 5.7 40.5 404.5 121.1 44.8 63.6 58.7 10.4 480.5 28.5 22.5 24.7 29.8 38.3 38.0 14.0 107.1 20.3 28.5 27.7 10.2 54.1 20.3 39.2 58.0 144.7 30.9 37.3 2.0 33.1 64.8 1591.0 25.7 37.9 35.6 7.5 20.2 63.4 42.2 11.6 21.9 14.4 32.5 28.2 36.9 21.9 34.8 39.4 3.4 220.6 39.5 19.3 94.3 162.9 64.8 12.7 31.8 54.5 30.0 70.8 50.5 15.2 PHKA1 PHKA ENSG00000067177 "Phosphorylase kinase regulatory subunit alpha 1" P46020 X 72578814-72714319 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Glycogen metabolism" "Calmodulin-binding, Muscle protein" "Disease variant, Glycogen storage disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "parathyroid gland: 32.0;skeletal muscle: 102.6;tongue: 89.2" "Cell type enriched" "Detected in many" 4 "Astrocytes: 85.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HDLM-2: 39.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001081, HPA075355" Enhanced Approved Vesicles,Cytosol NA NA "Cluster 80: Striated muscle - Unknown function" "Cluster 44: HDLM-2 - Immune response" "Cluster 64: Astrocytes - Nervous system maintenance" "Vesicles, Cytosol" "HPA001081: AB_1079607, HPA075355: " "unprognostic (3.68e-3)" "unprognostic (9.19e-2)" "unprognostic (1.09e-1)" "prognostic unfavorable (6.84e-4)" "unprognostic (3.52e-1)" "unprognostic (5.48e-2)" "unprognostic (1.23e-2)" "unprognostic (9.64e-2)" "unprognostic (1.85e-1)" "unprognostic (1.97e-1)" "unprognostic (2.18e-1)" "unprognostic (4.76e-1)" "unprognostic (9.45e-3)" "unprognostic (9.94e-2)" "unprognostic (2.02e-1)" "unprognostic (2.08e-1)" "unprognostic (1.12e-1)" 3.2 17.7 6.9 1.0 11.4 0.7 4.8 8.9 5.7 2.6 17.0 4.0 1.1 3.3 6.5 5.6 3.8 3.2 7.5 6.0 8.7 2.7 2.3 2.1 1.1 8.8 11.9 8.3 7.6 32.0 9.8 1.8 9.1 6.0 3.3 3.9 7.1 6.4 102.6 3.4 2.1 3.4 7.9 3.4 6.9 2.1 10.4 4.0 6.9 89.2 1.4 4.8 3.5 6.7 15.3 21.2 1.2 12.4 7.2 6.8 12.9 2.8 2.6 0.5 0.1 6.2 13.3 0.0 8.2 0.3 15.1 5.9 24.9 10.3 0.8 39.2 25.1 7.0 17.4 5.7 7.5 0.0 0.0 9.1 10.0 2.4 16.7 12.5 14.5 12.7 11.0 0.0 13.6 11.0 11.1 0.7 16.5 25.2 28.0 0.0 0.0 0.0 3.7 7.2 12.9 15.3 13.4 17.3 0.2 15.4 6.2 0.6 7.5 0.0 6.2 2.7 7.3 17.1 17.1 0.0 5.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.9 11.4 8.9 5.7 6.0 8.7 8.8 11.9 9.1 7.9 10.4 6.7 5.8 0.0 3.7 85.2 0.5 2.4 6.5 2.3 4.0 2.4 5.2 3.7 6.6 1.5 3.5 11.0 8.4 1.0 0.1 0.8 0.0 1.6 0.4 4.8 1.4 3.5 2.4 4.0 5.3 2.7 1.1 2.5 3.6 2.9 6.3 3.4 5.7 1.9 1.6 3.3 16.0 1.8 4.1 10.4 0.7 0.1 3.1 0.6 1.8 6.5 0.0 1.5 0.0 18.6 0.5 5.4 0.4 8.6 1.3 9.0 0.4 1.6 6.6 3.3 0.0 7.1 1.9 0.4 1.0 5.6 3.4 0.5 0.3 1.9 2.6 8.9 PHKA2 "PHK, PYK" ENSG00000044446 "Phosphorylase kinase regulatory subunit alpha 2" P46019 X 18892298-18984114 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Glycogen metabolism" Calmodulin-binding "Disease variant, Glycogen storage disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Granulosa cells: 42.7;Hepatocytes: 57.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002912 Approved Approved Nucleoplasm NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "HPA002912: AB_10961321" "unprognostic (3.90e-2)" "unprognostic (2.06e-2)" "unprognostic (5.10e-2)" "unprognostic (1.43e-2)" "unprognostic (1.90e-2)" "unprognostic (1.12e-2)" "prognostic unfavorable (1.25e-5)" "unprognostic (2.07e-2)" "unprognostic (3.42e-1)" "unprognostic (1.82e-1)" "prognostic favorable (7.68e-4)" "unprognostic (7.51e-2)" "prognostic unfavorable (1.55e-5)" "unprognostic (2.05e-1)" "unprognostic (1.58e-2)" "unprognostic (7.16e-2)" "prognostic favorable (2.96e-5)" 12.7 9.6 4.6 6.8 6.3 15.0 7.6 6.6 5.5 9.0 6.9 6.8 12.5 10.5 6.5 6.3 9.9 8.1 12.6 5.6 5.4 6.7 34.3 6.4 7.7 6.9 5.6 16.8 15.2 8.1 12.8 10.5 6.7 9.7 6.5 10.6 9.5 7.1 7.8 8.8 10.1 6.2 5.5 9.3 8.6 9.7 6.0 12.6 10.1 14.3 7.4 6.2 8.1 7.3 11.3 10.6 6.1 10.2 8.2 7.5 16.6 4.9 4.1 7.1 7.7 11.3 7.3 13.3 3.6 6.4 11.2 10.3 11.0 12.8 7.6 6.5 11.2 15.9 17.6 13.8 5.8 15.2 19.7 12.6 8.3 8.7 12.5 11.8 7.4 13.8 5.3 8.0 5.0 12.0 16.0 25.2 7.5 5.2 11.2 12.4 12.5 14.9 4.6 5.0 5.2 8.0 14.8 15.3 6.8 20.3 18.9 8.8 13.2 9.6 5.3 10.3 7.6 7.6 6.7 10.1 5.4 8.1 5.2 4.3 3.2 7.2 2.0 3.8 2.1 1.6 1.7 1.5 2.1 1.7 1.9 1.9 5.4 3.0 2.5 1.1 2.3 1.9 4.6 6.3 6.6 5.5 5.6 5.4 6.9 5.6 6.7 5.5 6.0 7.3 6.1 9.6 12.9 27.7 5.7 6.5 5.4 6.0 8.6 11.1 8.0 7.4 20.1 12.8 5.1 9.2 10.4 16.8 3.4 9.6 0.0 7.5 7.2 6.4 11.8 7.3 4.2 14.5 15.2 5.1 17.5 5.3 4.1 7.2 1.3 42.7 20.3 57.4 8.0 5.0 19.9 7.4 4.1 18.9 3.8 5.3 7.5 10.5 5.4 13.1 8.3 17.0 7.2 16.6 16.9 6.3 12.6 7.9 7.4 6.9 12.4 4.8 4.1 13.3 0.0 7.4 5.9 7.9 7.9 8.6 4.7 10.5 7.4 12.1 10.7 3.6 PHKB ENSG00000102893 "Phosphorylase kinase regulatory subunit beta" Q93100 16 47461123-47701523 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Glycogen metabolism" Calmodulin-binding "Disease variant, Glycogen storage disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 159.0" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA073380 Approved "Golgi apparatus" NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 25: Spermatids - Spermatogenesis" "Golgi apparatus" "HPA073380: AB_2686598" "unprognostic (2.87e-3)" "unprognostic (2.41e-1)" "prognostic favorable (3.69e-4)" "unprognostic (3.98e-2)" "unprognostic (3.98e-2)" "unprognostic (1.28e-2)" "unprognostic (6.73e-2)" "unprognostic (2.99e-2)" "unprognostic (2.35e-3)" "unprognostic (1.32e-1)" "unprognostic (1.51e-1)" "unprognostic (3.01e-2)" "prognostic favorable (3.89e-9)" "unprognostic (3.56e-2)" "unprognostic (1.87e-1)" "prognostic unfavorable (3.24e-4)" "unprognostic (2.53e-2)" 29.7 42.4 15.8 21.9 16.2 28.2 36.1 18.3 19.5 33.8 34.1 39.0 37.8 26.8 32.8 34.5 25.6 30.6 32.7 14.3 21.3 47.2 30.1 30.0 26.2 15.8 16.0 24.2 26.6 56.7 21.6 37.1 18.6 36.2 41.5 18.9 46.1 32.2 159.0 18.9 38.0 32.1 13.8 29.0 40.4 30.6 18.9 31.0 54.1 80.7 29.0 26.5 21.2 16.6 36.7 53.3 60.3 39.1 41.2 38.8 74.9 42.8 41.2 30.1 15.0 29.4 62.2 44.5 63.5 62.7 23.7 50.6 57.0 66.9 42.3 13.8 29.8 42.1 45.4 98.3 37.0 46.2 47.7 35.1 33.4 20.3 38.2 65.4 59.8 53.5 58.8 27.4 43.7 26.3 45.2 44.1 25.5 61.1 39.8 75.7 73.3 74.3 59.2 31.1 31.5 35.8 70.9 92.4 12.0 66.1 36.0 37.7 66.5 54.4 25.4 28.0 22.9 31.1 24.6 57.2 34.5 30.2 22.7 11.1 21.0 18.4 11.8 18.9 15.3 30.6 12.2 9.7 20.6 34.7 11.8 11.7 10.4 18.5 23.7 13.9 15.8 12.6 15.8 16.2 18.3 19.5 14.3 21.3 15.8 16.0 18.6 13.8 18.9 16.6 49.3 19.2 38.0 66.9 46.8 8.9 17.5 28.8 18.8 34.9 28.7 23.4 61.2 32.9 39.9 42.3 100.1 48.5 29.3 43.1 23.5 19.6 64.7 33.5 31.1 42.9 30.5 40.1 109.8 15.6 26.3 28.8 47.9 38.3 18.3 52.6 39.3 30.9 28.4 23.5 149.0 37.8 20.3 58.7 17.0 89.8 25.4 45.1 8.8 104.0 72.2 25.8 32.0 133.2 118.4 27.2 26.4 35.7 28.1 30.2 48.9 35.9 26.7 71.8 26.3 33.3 30.6 53.9 19.5 47.2 7.2 33.8 24.7 74.9 38.6 26.7 PHKG1 PHKG ENSG00000164776 "Phosphorylase kinase catalytic subunit gamma 1" Q16816 7 56080283-56092996 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Carbohydrate metabolism, Glycogen metabolism" "Calmodulin-binding, Kinase, Muscle protein, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in many" 12 "skeletal muscle: 264.6;tongue: 172.3" "Cell type enhanced" "Detected in many" "Cholangiocytes: 48.6;Hepatocytes: 46.5" "Cancer enriched" "Detected in many" 18 "glioma: 23.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in some" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA012057 Enhanced NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 80: Striated muscle - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 37: Myocytes - Muscle contraction" "HPA012057: AB_1855305" "unprognostic (2.00e-3)" "unprognostic (1.09e-1)" "unprognostic (7.09e-3)" "unprognostic (5.87e-3)" "unprognostic (2.19e-1)" "unprognostic (1.54e-2)" "unprognostic (1.31e-1)" "unprognostic (6.69e-3)" "unprognostic (2.10e-1)" "unprognostic (1.99e-1)" "unprognostic (9.14e-4)" "unprognostic (1.92e-1)" "unprognostic (7.97e-9)" "unprognostic (6.61e-3)" "unprognostic (2.34e-1)" "unprognostic (1.12e-2)" "unprognostic (3.85e-2)" 4.0 4.1 11.4 0.7 15.0 1.7 2.8 14.8 11.6 1.8 8.8 8.5 1.1 1.3 0.7 5.2 1.9 1.6 18.7 11.8 15.6 1.1 1.6 1.7 0.8 17.6 17.5 1.8 1.2 0.9 2.4 0.3 15.3 2.3 0.7 0.9 5.2 0.5 264.6 3.3 2.5 1.1 16.6 1.5 1.6 1.0 16.9 0.7 2.0 172.3 0.9 4.1 1.2 15.4 1.1 0.8 0.2 0.7 1.1 2.0 0.6 0.1 0.2 0.4 0.3 0.3 0.5 0.3 0.2 0.3 0.5 0.6 0.5 0.1 0.3 0.3 0.9 0.3 1.5 0.3 0.2 0.6 1.2 1.2 0.8 0.5 0.2 0.3 0.0 0.8 0.9 1.5 0.0 0.5 0.9 2.4 0.3 0.3 0.5 0.5 0.0 0.3 0.2 0.8 0.6 0.6 0.1 0.8 0.0 0.1 0.4 0.8 0.3 0.2 0.6 1.7 0.5 0.6 0.3 0.9 0.4 0.6 0.4 0.1 0.1 0.0 0.1 0.0 0.4 0.0 0.2 0.0 0.0 0.2 0.1 0.1 0.7 0.0 0.1 0.1 0.1 0.0 11.4 15.0 14.8 11.6 11.8 15.6 17.6 17.5 15.3 16.6 16.9 15.4 12.6 12.8 4.2 16.0 10.4 1.3 7.7 0.2 0.6 3.9 25.6 6.7 1.7 48.6 3.7 27.6 0.0 7.5 17.7 9.0 1.9 14.6 2.7 20.8 11.3 8.2 16.7 6.6 3.1 12.3 14.5 10.4 2.6 16.4 8.2 4.6 23.6 46.5 12.1 11.8 3.8 12.6 0.0 36.8 1.2 5.9 18.0 8.9 1.8 3.7 10.7 5.0 8.2 3.5 5.2 11.0 10.1 16.1 5.2 11.6 17.8 16.8 2.2 5.4 13.1 34.0 7.2 11.1 9.1 1.2 1.0 7.3 8.2 3.7 24.1 8.4 PHKG2 ENSG00000156873 "Phosphorylase kinase catalytic subunit gamma 2" P15735 16 30748293-30761176 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Carbohydrate metabolism, Glycogen metabolism" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Glycogen storage disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 4 "testis: 130.1" "Group enriched" "Detected in many" 5 "Early spermatids: 397.0;Late spermatids: 1576.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA065618, HPA068751" Supported Cytosol NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 78: Testis - Spermatogenesis" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 25: Spermatids - Spermatogenesis" Cytosol "HPA065618: AB_2685520, HPA068751: AB_2686025" "unprognostic (7.63e-3)" "prognostic favorable (7.90e-4)" "prognostic unfavorable (9.92e-4)" "unprognostic (1.08e-1)" "unprognostic (1.25e-1)" "unprognostic (5.81e-2)" "unprognostic (3.72e-2)" "prognostic favorable (1.90e-4)" "unprognostic (6.45e-2)" "unprognostic (1.25e-2)" "prognostic favorable (8.02e-4)" "unprognostic (6.15e-2)" "unprognostic (5.27e-2)" "unprognostic (1.36e-2)" "unprognostic (2.41e-1)" "unprognostic (2.18e-2)" "unprognostic (3.03e-2)" 9.0 15.8 17.5 11.5 16.9 30.0 9.9 17.1 18.7 10.0 15.9 12.9 11.0 10.1 9.5 10.2 11.7 8.2 12.1 18.9 16.4 14.7 19.1 10.0 12.5 17.7 17.2 8.3 9.7 18.9 15.9 7.8 18.8 14.7 12.0 8.9 11.5 12.0 13.2 14.6 12.0 9.9 16.0 12.9 13.8 130.1 17.5 11.6 13.6 8.8 12.7 10.1 9.2 16.2 24.7 16.3 13.1 16.2 11.8 9.4 29.8 17.2 24.6 22.1 25.1 13.5 12.6 21.0 19.3 17.1 11.5 24.0 13.5 21.5 17.6 11.4 38.2 11.9 28.8 38.7 18.1 18.1 16.9 12.9 11.2 21.4 9.9 10.7 22.8 15.3 16.1 11.7 16.3 55.5 22.3 27.1 18.0 17.6 18.0 29.4 20.0 28.2 25.7 27.2 17.5 11.9 13.5 38.1 16.6 11.8 30.1 15.5 13.6 14.4 15.1 17.2 16.0 24.1 14.4 14.8 27.3 35.2 11.4 44.0 55.8 114.9 37.8 56.5 30.9 21.1 27.1 38.8 52.0 21.5 24.2 27.7 44.7 63.8 42.3 46.1 43.3 49.0 17.5 16.9 17.1 18.7 18.9 16.4 17.7 17.2 18.8 16.0 17.5 16.2 10.4 12.8 21.7 13.7 18.5 21.0 15.2 28.7 22.8 8.8 21.8 17.1 15.9 10.0 32.0 18.4 10.4 29.6 32.2 32.1 27.4 11.9 397.0 35.8 13.0 10.0 16.3 20.2 14.7 24.4 41.5 11.8 44.4 38.8 13.3 16.1 10.4 24.1 28.2 20.2 14.5 21.4 26.4 19.1 27.2 1576.6 17.4 26.4 12.4 11.2 40.3 13.7 39.1 9.0 8.1 19.6 18.5 23.3 20.5 31.5 27.8 47.3 33.0 9.9 0.0 8.9 14.8 180.5 22.9 20.5 23.0 75.5 25.9 20.8 27.0 16.9 PHLPP1 "KIAA0606, PHLPP, PLEKHE1, PPM3A, SCOP" ENSG00000081913 "PH domain and leucine rich repeat protein phosphatase 1" O60346 18 62715541-62980433 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Apoptosis "Hydrolase, Protein phosphatase" "Tumor suppressor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 6 "brain: 107.2" "Group enriched" "Detected in many" 10 "Astrocytes: 423.7;Oligodendrocyte precursor cells: 538.3;Oligodendrocytes: 1663.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 7 "neutrophil: 4.0;T-reg: 1.3" "Group enriched" "Detected in many" 7 "granulocytes: 4.0;T-cells: 1.3" "Cell line enhanced" "Detected in all" "REH: 32.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA020200 Approved "Intracellular and membrane" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 70: Brain - Nervous system development" "Cluster 14: REH - Unknown function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA020200: AB_2670383" "unprognostic (1.38e-1)" "unprognostic (3.61e-2)" "unprognostic (2.26e-1)" "unprognostic (1.18e-1)" "unprognostic (1.89e-1)" "unprognostic (3.07e-2)" "unprognostic (5.57e-2)" "unprognostic (5.24e-1)" "unprognostic (1.63e-1)" "unprognostic (3.10e-1)" "unprognostic (2.95e-1)" "unprognostic (6.03e-2)" "prognostic favorable (5.35e-8)" "unprognostic (1.52e-1)" "unprognostic (3.49e-2)" "unprognostic (8.13e-2)" "unprognostic (8.25e-2)" 5.5 14.6 46.4 1.9 74.3 7.3 6.4 49.5 59.8 4.4 17.1 5.2 5.4 4.6 1.9 7.6 3.4 4.1 3.4 45.6 46.4 3.2 16.6 3.4 2.7 61.8 58.4 4.4 7.0 5.7 7.5 5.5 53.8 4.0 5.6 16.1 10.8 3.5 4.2 12.5 4.9 3.3 47.0 1.8 4.9 10.8 58.7 4.4 4.6 3.7 3.6 5.5 4.8 107.2 13.7 5.0 20.2 6.8 3.4 2.9 15.8 4.0 3.6 7.8 8.0 11.1 8.0 9.1 2.4 6.1 3.1 16.3 10.5 6.4 10.0 28.4 8.8 3.1 5.4 20.6 4.8 4.7 1.5 3.0 4.1 8.4 7.6 6.4 5.6 4.9 8.0 17.9 7.6 3.0 3.5 4.1 8.2 2.7 4.9 32.7 11.5 11.1 4.5 17.5 9.3 3.7 4.4 9.9 8.2 11.8 4.4 13.3 7.2 6.4 3.0 3.9 9.4 2.0 1.1 10.6 3.8 5.4 5.0 0.0 0.1 0.1 0.3 0.0 0.0 0.3 0.0 0.0 0.4 0.1 0.2 0.0 4.0 0.3 0.1 0.2 1.3 0.1 46.4 74.3 49.5 59.8 45.6 46.4 61.8 58.4 53.8 47.0 58.7 107.2 10.1 3.2 1.5 423.7 1.9 16.8 5.0 2.9 8.0 21.2 12.1 11.3 4.1 11.5 6.3 0.0 29.2 12.9 3.3 8.4 1.9 3.8 33.5 13.7 6.0 8.1 12.1 3.8 80.1 4.1 5.8 7.0 10.2 26.6 2.5 9.6 5.3 21.5 2.4 26.9 64.7 8.5 2.0 2.5 9.8 36.4 5.9 5.8 24.9 79.6 2.6 83.6 2.1 538.3 1663.2 4.5 8.0 3.8 1.0 7.5 7.4 1.9 10.0 17.4 0.0 13.5 5.3 8.0 15.4 13.2 18.6 26.1 2.7 8.3 11.1 11.0 PHLPP2 "KIAA0931, PHLPPL, PPM3B" ENSG00000040199 "PH domain and leucine rich repeat protein phosphatase 2" Q6ZVD8 16 71637835-71724701 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 22.0;retina: 32.2" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 104.3;Distal enterocytes: 75.5;Excitatory neurons: 69.5;Proximal enterocytes: 73.7;Rod photoreceptor cells: 68.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040761, HPA041837, HPA048598" Approved Supported "Nucleoplasm,Cytokinetic bridge,Mitotic spindle,Cytosol" Yes No "Cluster 15: NK-cells - Transcription" "Cluster 45: Intestine - Brush border" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 45: Enterocytes - Digestion" Cytosol "Nucleoplasm, Cytokinetic bridge, Mitotic spindle" "HPA040761: , HPA041837: , HPA048598: AB_2680459" "unprognostic (5.67e-2)" "unprognostic (2.00e-1)" "unprognostic (2.29e-2)" "unprognostic (2.44e-2)" "unprognostic (1.76e-1)" "unprognostic (1.59e-1)" "unprognostic (1.17e-1)" "unprognostic (3.27e-1)" "unprognostic (1.22e-1)" "unprognostic (3.43e-1)" "unprognostic (1.97e-4)" "unprognostic (3.08e-2)" "unprognostic (8.85e-3)" "unprognostic (6.41e-2)" "unprognostic (4.92e-2)" "unprognostic (8.46e-3)" "unprognostic (8.27e-2)" 4.2 2.8 6.6 2.8 7.5 6.5 2.7 5.8 7.4 3.5 0.1 11.7 11.1 3.7 2.9 1.4 3.2 2.4 2.8 7.8 4.8 3.4 3.0 3.1 3.5 4.6 3.9 4.2 3.1 4.5 4.0 2.7 4.7 2.7 12.2 32.2 1.7 3.4 1.9 1.8 22.0 4.5 0.6 2.5 2.4 6.8 5.3 1.9 6.6 2.6 3.2 3.3 2.4 5.1 6.0 7.8 8.3 9.3 6.5 7.8 4.8 8.8 8.0 12.5 10.1 7.2 1.9 11.8 3.4 14.6 9.0 12.4 12.1 4.5 16.1 4.2 6.5 3.3 7.3 4.8 5.1 2.9 5.0 5.8 2.5 17.7 5.7 5.2 4.7 4.1 3.0 3.2 8.7 12.7 3.9 2.3 6.5 1.9 2.1 6.3 7.3 3.9 5.9 4.5 7.2 3.8 18.9 5.1 3.1 6.4 6.3 1.6 6.5 12.5 9.0 5.3 7.4 7.1 5.4 11.9 7.7 2.3 2.8 0.2 0.1 0.0 0.2 0.1 0.2 0.5 0.1 0.3 0.1 0.3 0.2 0.2 0.2 0.7 0.1 0.5 0.3 0.1 6.6 7.5 5.8 7.4 7.8 4.8 4.6 3.9 4.7 0.6 5.3 5.1 4.0 9.6 2.2 26.1 7.4 9.3 5.1 3.5 7.4 20.6 6.9 5.6 3.3 0.0 3.6 3.7 104.3 4.3 3.8 75.5 0.0 2.7 12.0 2.9 6.1 5.3 6.0 22.9 69.5 2.3 0.4 7.7 1.1 5.1 10.2 11.3 2.9 4.1 1.5 23.5 45.9 6.7 4.1 7.0 12.7 6.3 5.3 2.7 14.2 10.3 3.2 6.5 1.0 30.7 32.7 2.5 31.4 5.3 4.0 8.2 73.7 5.1 3.1 68.6 6.6 7.8 7.9 31.6 20.4 1.9 9.1 1.4 4.9 1.7 9.2 2.2 PHYKPL "AGXT2L2, MGC15875" ENSG00000175309 "5-phosphohydroxy-L-lysine phospho-lyase" Q8IUZ5 5 178208471-178232802 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Lyase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036461, HPA063608" Approved Approved Mitochondria Yes No 160000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 34: Non-specific - Transcription" "Cluster 30: Epithelial cell lines - Translation" "Cluster 52: Non-specific - Transcription" Mitochondria "HPA036461: AB_10670717, HPA063608: AB_2685059" "unprognostic (3.29e-3)" "unprognostic (2.60e-1)" "unprognostic (5.51e-2)" "unprognostic (9.75e-2)" "unprognostic (1.28e-1)" "unprognostic (1.47e-1)" "unprognostic (1.24e-1)" "unprognostic (1.06e-2)" "unprognostic (1.68e-2)" "unprognostic (3.29e-1)" "unprognostic (5.38e-2)" "unprognostic (1.02e-3)" "prognostic unfavorable (3.82e-5)" "unprognostic (3.66e-2)" "unprognostic (1.55e-1)" "unprognostic (1.02e-1)" "unprognostic (2.41e-3)" 23.2 10.6 7.4 16.4 8.2 14.9 14.0 6.8 8.6 12.3 8.3 23.9 20.7 14.3 15.8 11.1 13.9 14.4 15.5 6.7 8.3 17.5 42.2 15.8 24.5 11.4 8.3 12.5 15.6 13.7 5.2 16.3 10.0 13.7 30.8 3.4 13.8 12.0 19.6 10.7 24.8 18.5 7.6 17.2 15.5 5.9 9.5 25.1 19.7 18.7 23.6 13.7 9.6 11.7 9.6 3.8 9.0 3.6 21.6 17.4 13.9 5.6 6.2 7.6 11.8 9.7 11.7 13.0 18.4 17.6 9.7 6.2 7.7 14.3 8.5 24.0 8.7 15.6 18.0 7.1 35.1 9.2 11.4 19.6 15.0 9.3 22.4 14.9 24.9 18.6 11.8 26.7 11.3 13.1 13.1 5.5 1.9 11.5 12.4 9.1 4.3 25.0 13.4 8.3 5.7 5.4 9.2 5.2 9.4 10.2 5.5 7.4 9.9 7.8 7.0 5.1 6.2 18.8 5.5 7.2 2.2 9.2 5.2 16.7 41.7 36.9 20.3 46.8 20.4 28.4 22.2 22.9 53.4 26.3 27.3 22.2 9.2 23.7 47.2 70.9 28.6 33.2 7.4 8.2 6.8 8.6 6.7 8.3 11.4 8.3 10.0 7.6 9.5 11.7 23.1 19.2 14.3 31.6 63.0 10.7 43.1 16.1 25.0 21.9 17.2 14.5 17.4 37.1 13.0 23.9 25.0 18.4 72.5 96.1 19.6 24.6 21.7 13.2 27.7 26.2 19.2 30.7 20.7 18.6 20.2 33.4 76.9 13.8 12.7 38.4 31.1 30.1 31.7 15.2 17.9 40.8 6.1 37.1 22.9 55.3 42.6 43.3 24.9 36.5 61.1 25.0 70.0 29.1 45.2 15.1 64.5 25.2 51.4 30.3 119.2 43.1 13.6 26.4 13.1 34.5 23.6 37.2 25.9 14.6 10.4 22.0 58.9 36.3 39.2 36.6 PIK3R4 "p150, VPS15" ENSG00000196455 "Phosphoinositide-3-kinase regulatory subunit 4" Q99570 3 130678934-130746829 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036032, HPA036033" Approved Approved Vesicles,Microtubules NA NA "Cluster 46: Basophils - DNA binding" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" Vesicles Microtubules "HPA036032: AB_10610281, HPA036033: AB_2674911" "unprognostic (7.50e-2)" "unprognostic (3.90e-3)" "unprognostic (1.68e-1)" "unprognostic (4.05e-3)" "unprognostic (2.88e-1)" "unprognostic (1.28e-1)" "unprognostic (1.34e-1)" "unprognostic (1.21e-1)" "unprognostic (1.11e-1)" "unprognostic (2.67e-1)" "unprognostic (1.02e-3)" "unprognostic (7.26e-2)" "prognostic favorable (4.40e-6)" "unprognostic (8.25e-2)" "unprognostic (3.72e-1)" "unprognostic (2.27e-1)" "unprognostic (1.05e-1)" 8.8 8.5 3.7 7.8 4.2 8.9 10.0 5.2 4.9 9.4 5.6 8.2 7.5 10.1 7.9 8.0 9.1 7.2 7.6 4.1 4.5 10.5 21.2 9.6 9.4 3.2 3.6 12.4 6.9 17.6 6.1 9.7 3.8 9.8 8.1 16.5 7.6 9.6 7.3 7.8 8.0 10.4 3.8 10.0 7.5 11.4 3.2 11.4 13.1 8.6 10.4 9.0 6.5 7.1 20.7 12.9 18.5 13.4 26.6 21.1 12.8 15.0 17.9 20.2 23.3 16.7 17.1 24.2 18.4 15.2 16.1 28.7 30.7 23.3 31.6 14.7 11.3 19.7 13.8 11.7 12.2 30.3 9.5 14.7 16.4 21.7 13.6 12.6 19.0 13.8 23.3 11.9 18.1 18.1 24.9 9.2 23.3 18.6 12.4 17.2 21.4 21.9 13.2 16.7 17.0 12.4 21.6 13.4 15.3 21.5 18.6 13.1 15.2 15.5 13.3 17.6 12.2 13.8 13.5 31.2 17.0 11.3 14.7 9.7 5.3 7.0 6.3 6.0 9.3 5.6 5.7 4.7 6.9 3.5 6.6 6.0 4.4 8.5 6.6 2.4 6.8 5.3 3.7 4.2 5.2 4.9 4.1 4.5 3.2 3.6 3.8 3.8 3.2 7.1 8.3 6.4 8.7 18.6 8.8 3.8 3.9 5.7 10.8 8.1 5.7 4.7 7.7 8.6 9.6 11.0 14.6 5.6 7.2 5.5 1.9 5.0 4.4 8.9 7.5 8.9 3.0 9.2 28.5 5.8 3.4 6.9 13.3 9.9 9.5 9.5 7.5 18.2 5.9 5.0 30.3 6.8 8.2 6.4 2.6 3.1 9.6 7.3 5.4 20.6 7.1 9.0 6.2 22.1 32.9 6.6 4.3 11.7 6.9 4.8 6.2 4.2 12.6 12.6 6.6 8.9 6.2 17.0 13.9 9.5 4.4 4.2 7.5 9.6 6.1 3.4 PIM1 PIM ENSG00000137193 "Pim-1 proto-oncogene, serine/threonine kinase" P11309 6 37170152-37175428 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 219.0" "Cell type enhanced" "Detected in many" "Erythroid cells: 368.2;Suprabasal keratinocytes: 228.6;Urothelial cells: 455.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 321.3" "Lineage enriched" "Detected in all" 4 "granulocytes: 321.3" "Cell line enhanced" "Detected in all" "HEL: 219.9;HMC-1: 391.5;K-562: 192.7;U-698: 735.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003941, CAB017040" Uncertain Supported Nucleoplasm,Nucleoli,Cytosol NA NA "Cluster 46: Basophils - DNA binding" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" Cytosol "Nucleoplasm, Nucleoli" "CAB017040: , HPA003941: AB_1079618" "unprognostic (1.25e-2)" "unprognostic (4.77e-1)" "unprognostic (3.61e-2)" "prognostic unfavorable (9.73e-4)" "unprognostic (1.91e-2)" "unprognostic (1.06e-1)" "unprognostic (3.75e-1)" "unprognostic (4.64e-2)" "unprognostic (2.36e-1)" "unprognostic (1.10e-1)" "unprognostic (2.65e-2)" "unprognostic (7.32e-2)" "unprognostic (2.14e-3)" "unprognostic (8.16e-3)" "unprognostic (1.04e-1)" "unprognostic (5.26e-3)" "unprognostic (2.90e-1)" 152.8 14.4 8.5 42.3 8.6 219.0 46.2 10.5 10.7 82.9 10.0 45.8 39.2 46.3 2.6 201.5 66.4 52.6 65.4 7.9 11.6 27.0 58.0 49.8 38.5 15.1 12.2 60.4 20.4 3.4 14.8 28.9 12.8 22.5 17.8 8.2 41.1 7.5 36.3 109.8 44.4 38.1 12.3 61.7 40.3 10.7 11.6 26.6 22.7 5.8 26.8 101.6 113.3 12.1 19.1 7.9 12.1 6.7 27.2 14.5 141.9 6.7 20.3 13.5 21.5 28.3 26.2 38.3 10.4 8.0 30.2 21.7 12.7 20.1 12.3 174.4 8.4 219.9 8.7 37.0 27.9 3.8 391.5 49.0 24.5 12.4 8.3 14.9 4.0 9.2 192.7 59.7 2.2 5.0 12.3 19.9 22.7 35.4 12.1 29.7 22.0 45.7 3.9 114.4 58.8 11.9 14.7 1.7 3.8 27.9 3.2 6.5 7.4 7.8 23.3 35.6 8.5 28.0 15.9 735.7 3.4 55.3 8.1 321.3 8.0 113.5 60.3 7.3 77.7 7.1 53.4 53.8 6.3 5.2 47.1 36.9 61.7 39.8 4.2 1.9 41.3 42.1 8.5 8.6 10.5 10.7 7.9 11.6 15.1 12.2 12.8 12.3 11.6 12.1 41.1 22.4 16.0 2.9 35.1 127.8 166.5 63.3 26.7 4.9 9.6 5.3 36.0 18.6 37.6 9.2 0.0 36.5 55.0 50.4 5.9 40.6 4.8 40.3 125.8 33.3 37.1 368.2 2.4 17.2 121.8 67.4 26.0 92.0 49.3 27.5 11.0 33.8 53.6 15.2 2.2 12.4 44.7 44.3 47.4 12.4 8.1 53.9 44.4 4.7 72.3 7.6 112.3 1.0 0.9 60.7 34.2 3.0 190.1 109.6 51.1 17.2 12.9 1.7 0.0 34.2 41.3 14.5 33.9 92.8 228.6 80.7 118.0 1.1 7.8 455.2 PIM2 ENSG00000102096 "Pim-2 proto-oncogene, serine/threonine kinase" Q9P1W9 X 48913182-48919024 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 102.3;intestine: 87.6;lymphoid tissue: 163.9" "Cell type enriched" "Detected in many" 4 "Plasma cells: 738.8" "Cancer enriched" "Detected in all" 6 "testis cancer: 171.3" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Group enriched" "Detected in all" 5 "HDLM-2: 567.6;Karpas-707: 675.0;RPMI-8226: 703.9;U-266/70: 1218.7;U-266/84: 1160.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000285 Approved Cytosol NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 16: Immune cells - Immune response" "Cluster 29: U-266 - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" Cytosol "HPA000285: AB_1079619" "unprognostic (2.34e-3)" "prognostic favorable (4.05e-5)" "unprognostic (8.04e-2)" "unprognostic (7.30e-2)" "unprognostic (6.41e-3)" "unprognostic (2.74e-3)" "unprognostic (2.84e-1)" "unprognostic (5.23e-2)" "unprognostic (2.47e-2)" "unprognostic (4.01e-2)" "unprognostic (1.33e-3)" "unprognostic (2.73e-1)" "prognostic unfavorable (1.17e-11)" "unprognostic (3.36e-2)" "unprognostic (1.96e-2)" "unprognostic (1.27e-1)" "unprognostic (4.38e-2)" 7.9 7.1 10.9 85.4 11.4 102.3 8.8 9.6 12.3 6.1 11.1 40.8 87.6 5.1 10.1 8.2 11.9 16.7 5.2 15.4 12.4 9.8 10.4 23.5 114.3 9.7 10.7 10.3 4.7 3.8 10.1 4.9 11.7 7.4 50.9 5.6 36.4 7.3 2.5 6.3 46.4 6.9 10.3 163.9 45.1 10.1 13.5 45.5 10.1 2.7 104.7 45.6 6.4 8.8 17.5 14.8 8.0 15.4 2.8 2.0 11.7 10.5 13.1 14.8 13.2 13.3 12.9 74.5 4.8 5.3 5.6 10.6 25.1 10.0 14.1 567.6 19.6 90.8 15.0 13.9 6.2 21.7 58.7 5.9 8.4 15.3 9.2 12.1 5.5 9.8 97.8 675.0 8.4 12.6 8.4 45.2 165.2 6.1 22.7 9.9 5.4 703.9 14.9 2.6 5.4 7.8 11.5 8.0 8.3 36.9 19.3 29.8 3.6 3.5 2.5 3.1 10.6 1218.7 1160.5 144.1 14.0 19.0 3.7 279.1 8.2 77.7 60.4 9.7 102.3 124.8 165.9 85.6 13.2 73.5 172.4 113.3 195.5 92.7 17.4 15.2 331.9 79.0 10.9 11.4 9.6 12.3 15.4 12.4 9.7 10.7 11.7 10.3 13.5 8.8 2.9 12.8 36.0 1.0 161.6 20.3 9.0 7.1 45.5 2.6 16.2 4.7 3.5 2.8 9.9 3.7 2.1 5.8 46.8 5.7 3.9 3.3 1.9 15.6 1.0 5.3 13.1 49.9 2.3 3.5 9.1 5.1 10.7 3.9 23.4 1.3 4.2 6.3 7.2 11.8 2.2 7.5 18.3 7.5 123.1 1.8 1.8 19.8 94.3 0.0 99.5 2.2 38.1 0.5 1.0 2.0 3.7 4.1 738.8 4.6 4.1 6.8 16.3 2.1 0.0 3.8 6.2 2.2 1.6 15.7 13.8 2.5 97.1 8.6 11.8 3.4 PIM3 ENSG00000198355 "Pim-3 proto-oncogene, serine/threonine kinase" Q86V86 22 49960768-49964072 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Langerhans cells: 408.4;Syncytiotrophoblasts: 389.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 20.7" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Karpas-707: 163.3;SK-BR-3: 144.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA068758 Supported Cytosol NA Yes "Cluster 9: Neutrophils - Innate immune response" "Cluster 72: Non-specific - Transcription" "Cluster 2: Karpas-707 - Immune response" "Cluster 41: Macrophages - Immune response" Cytosol "HPA068758: AB_2686026" "unprognostic (3.67e-2)" "unprognostic (7.69e-3)" "unprognostic (1.07e-1)" "unprognostic (1.11e-1)" "unprognostic (3.67e-2)" "unprognostic (5.83e-2)" "unprognostic (1.48e-2)" "unprognostic (1.13e-2)" "unprognostic (2.71e-2)" "prognostic unfavorable (9.68e-4)" "unprognostic (2.00e-2)" "unprognostic (1.00e-1)" "prognostic favorable (8.09e-4)" "unprognostic (5.59e-3)" "unprognostic (1.71e-1)" "unprognostic (3.92e-3)" "unprognostic (7.27e-3)" 97.8 48.4 25.9 31.3 31.3 114.3 80.2 32.8 38.1 49.2 26.9 55.1 23.8 40.8 12.7 80.8 54.0 25.8 68.7 25.2 32.6 113.3 92.9 107.1 28.2 40.6 36.1 35.7 73.1 21.6 51.3 21.3 38.0 87.3 10.4 3.1 93.5 22.6 112.0 116.4 51.6 9.9 30.3 80.7 118.1 33.9 35.2 19.0 54.9 35.0 13.0 71.0 68.6 39.9 26.8 17.7 11.6 21.9 9.0 6.7 65.5 16.5 26.7 19.4 14.0 29.5 22.3 47.3 20.1 4.6 39.1 22.5 22.3 12.6 6.9 35.8 92.1 19.5 46.3 36.0 41.8 42.5 36.0 12.8 41.0 11.9 20.2 10.5 63.5 31.7 27.0 163.3 5.9 60.6 21.7 76.4 24.2 28.1 27.8 100.3 19.2 57.6 10.6 20.3 41.1 28.6 32.2 144.7 109.2 10.7 19.0 56.4 16.8 12.1 51.5 19.8 27.1 82.2 56.9 41.4 30.1 24.1 33.2 0.0 4.0 0.1 2.2 4.1 2.5 4.3 5.0 4.4 3.1 7.5 4.8 1.9 20.7 1.7 5.2 7.0 5.8 2.7 25.9 31.3 32.8 38.1 25.2 32.6 40.6 36.1 38.0 30.3 35.2 39.9 120.2 64.1 85.9 6.5 107.7 227.3 236.8 79.1 96.8 31.5 99.2 67.3 32.8 121.5 72.8 80.9 2.1 56.9 79.5 57.9 84.1 50.9 5.1 114.2 76.3 167.7 97.7 10.8 10.2 54.5 346.5 69.0 202.3 170.5 69.3 16.8 98.6 45.9 69.7 62.2 6.7 101.7 81.4 41.1 408.4 4.8 32.3 134.8 108.5 6.5 35.8 14.0 11.3 6.6 20.5 71.0 94.6 11.3 95.1 298.4 58.1 88.5 40.9 16.5 26.3 39.4 57.3 26.1 37.7 95.3 204.7 389.9 90.4 11.6 79.0 266.0 PIN1 dod ENSG00000127445 "Peptidylprolyl cis/trans isomerase, NIMA-interacting 1" Q13526 19 9835257-9849689 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle" "Isomerase, Rotamase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 782.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004528, CAB009326, HPA068650, HPA070887" Enhanced Enhanced Nucleoplasm,Cytosol NA NA 120000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 35: Non-specific - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 31: Spermatids - Spermatogenesis" Nucleoplasm Cytosol "CAB004528: AB_628132, CAB009326: AB_2237080, HPA068650: AB_2686014, HPA070887: " "unprognostic (2.54e-1)" "unprognostic (6.14e-3)" "unprognostic (6.50e-2)" "unprognostic (4.36e-2)" "unprognostic (1.71e-2)" "unprognostic (6.50e-3)" "unprognostic (1.90e-1)" "unprognostic (2.86e-2)" "unprognostic (2.67e-1)" "unprognostic (7.23e-3)" "prognostic favorable (3.25e-4)" "unprognostic (9.43e-2)" "prognostic favorable (7.80e-5)" "unprognostic (2.20e-2)" "unprognostic (2.56e-1)" "unprognostic (3.13e-2)" "unprognostic (1.21e-2)" 55.3 90.1 130.7 31.2 140.6 48.1 52.3 132.5 201.4 59.4 99.9 83.2 36.4 61.7 7.2 59.5 63.7 13.0 105.5 149.6 141.4 70.1 63.2 49.0 26.4 152.6 134.4 54.6 43.5 28.2 69.2 20.5 156.7 74.7 9.3 20.6 39.6 22.0 90.4 54.3 49.0 16.7 113.9 53.8 61.1 98.4 133.8 42.3 44.8 33.4 12.4 67.4 52.4 132.7 116.8 104.5 75.4 70.8 25.8 22.9 45.1 85.3 35.7 60.9 58.3 97.5 36.1 72.0 132.0 31.7 63.8 58.4 52.2 49.6 19.3 153.9 223.5 187.0 137.2 85.5 41.9 88.0 105.0 31.5 33.5 39.5 18.7 45.7 49.9 124.1 86.1 105.4 37.3 81.0 133.7 338.6 72.8 47.8 156.8 120.6 79.4 121.2 44.5 56.4 95.1 112.4 82.0 40.5 96.6 30.8 51.9 104.3 87.3 85.6 68.3 133.6 139.1 135.0 137.0 97.1 90.9 111.3 107.2 280.9 181.0 397.6 170.1 202.0 159.8 165.5 165.5 171.8 171.4 176.5 130.5 146.0 114.0 192.2 195.8 316.9 245.5 214.7 130.7 140.6 132.5 201.4 149.6 141.4 152.6 134.4 156.7 113.9 133.8 132.7 73.8 28.9 20.5 11.1 48.8 48.3 65.7 153.9 23.3 77.3 56.1 62.0 79.6 44.3 67.4 62.5 12.5 119.4 81.3 82.3 164.4 101.5 270.5 75.9 57.6 65.6 99.9 78.9 41.3 108.6 98.1 66.5 38.7 40.6 63.5 83.6 56.4 45.8 140.7 60.6 39.2 70.6 160.7 54.7 75.2 782.4 90.1 60.6 124.5 20.6 131.6 87.9 138.0 11.6 24.3 113.7 81.2 129.8 74.3 68.9 97.0 143.8 104.5 76.0 65.7 52.3 98.6 186.7 94.7 54.0 65.9 55.0 77.8 81.8 69.2 58.5 PIN4 "EPVH, PAR14, PAR17" ENSG00000102309 "Peptidylprolyl cis/trans isomerase, NIMA-interacting 4" Q9Y237 X 72181353-72302926 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA-binding, Isomerase, Rotamase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA054483, HPA064504" Approved Supported "Nucleoplasm,Nucleoli,Mitotic chromosome" Yes No "Cluster 12: Non-specific - Basic cellular processes" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Nucleoli" "Mitotic chromosome" "HPA054483: AB_2682503, HPA064504: AB_2685274" "unprognostic (2.47e-1)" "unprognostic (6.97e-3)" "unprognostic (1.65e-1)" "unprognostic (3.77e-2)" "unprognostic (8.42e-2)" "unprognostic (1.30e-2)" "unprognostic (1.14e-2)" "prognostic favorable (6.37e-4)" "unprognostic (1.56e-1)" "unprognostic (2.13e-2)" "unprognostic (2.49e-1)" "unprognostic (9.54e-2)" "unprognostic (2.09e-3)" "unprognostic (1.92e-1)" "prognostic favorable (2.58e-4)" "unprognostic (3.34e-3)" "prognostic favorable (2.66e-4)" 14.1 14.8 23.5 10.4 24.0 8.7 16.9 25.2 36.3 15.2 24.0 16.2 11.5 14.7 21.5 14.4 12.9 7.3 19.0 23.6 24.8 19.7 28.6 10.6 10.5 24.4 24.2 16.1 13.1 20.4 13.9 11.8 24.2 15.6 12.7 18.3 16.1 10.1 19.4 10.6 12.7 10.8 24.0 13.9 15.8 5.7 23.8 17.5 16.5 20.4 11.1 13.2 14.9 25.4 36.8 41.2 42.5 29.9 28.1 23.4 23.1 24.6 26.8 28.7 29.1 20.8 26.4 11.2 68.6 25.2 39.2 25.8 38.6 43.0 35.6 26.9 83.3 18.8 51.1 55.3 14.9 29.9 14.8 15.7 22.5 32.0 11.1 32.4 29.1 32.5 32.1 46.6 20.4 43.4 25.3 49.9 30.3 42.4 36.7 25.8 34.7 32.3 37.1 24.7 27.0 48.1 28.5 13.3 27.0 32.0 20.3 25.9 30.7 13.4 19.9 36.8 17.7 15.4 18.5 17.9 38.5 28.3 14.7 42.7 37.1 40.6 41.8 41.1 41.7 49.2 43.7 40.3 38.0 45.6 44.1 44.8 15.7 41.1 39.4 44.6 58.1 39.6 23.5 24.0 25.2 36.3 23.6 24.8 24.4 24.2 24.2 24.0 23.8 25.4 68.3 67.3 48.2 14.0 44.4 43.2 63.3 167.9 36.5 26.7 67.2 94.5 84.9 78.6 89.4 119.5 8.4 162.8 44.5 99.2 181.9 125.0 13.5 78.6 66.7 71.5 92.7 71.7 17.8 117.9 89.0 59.9 45.3 56.6 57.6 46.3 92.4 288.5 110.3 28.6 17.8 93.7 128.1 72.9 44.9 9.3 74.6 50.7 60.5 7.5 69.6 90.7 80.3 16.6 27.3 136.3 114.9 81.3 38.7 51.5 162.0 296.1 95.9 42.9 85.5 65.9 94.6 19.6 42.6 51.3 46.9 120.7 44.8 53.9 88.5 54.8 PINK1 "BRPK, PARK6" ENSG00000158828 "PTEN induced kinase 1" Q9BXM7 1 20633458-20651511 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Autophagy "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 384.4;tongue: 392.3" "Cell type enhanced" "Detected in many" "Late spermatids: 151.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 8.1" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001931, CAB026191" Enhanced NA NA "Cluster 10: Basophils - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB026191: , HPA001931: AB_1079620" "unprognostic (3.73e-3)" "unprognostic (2.29e-2)" "unprognostic (3.22e-1)" "unprognostic (4.33e-2)" "unprognostic (4.91e-2)" "unprognostic (2.93e-2)" "unprognostic (1.56e-2)" "unprognostic (3.36e-2)" "unprognostic (3.51e-2)" "unprognostic (4.06e-3)" "unprognostic (3.34e-2)" "unprognostic (2.54e-1)" "prognostic favorable (1.11e-16)" "unprognostic (2.68e-1)" "unprognostic (1.62e-1)" "unprognostic (6.57e-2)" "unprognostic (1.08e-1)" 50.7 127.2 119.3 13.7 103.4 13.0 41.9 104.6 110.9 37.9 73.0 62.3 32.3 43.9 18.8 48.8 34.4 23.5 153.4 106.6 107.0 56.8 76.8 30.1 10.8 118.5 127.8 30.1 52.7 66.5 33.4 21.3 118.3 37.1 15.0 29.4 55.0 29.7 384.4 55.3 35.2 20.0 124.9 27.9 46.7 94.8 132.1 12.3 41.6 392.3 8.3 47.4 42.7 95.0 49.9 22.2 10.3 29.6 34.6 32.8 10.7 68.2 67.9 32.4 56.1 7.7 39.3 11.7 52.6 69.9 75.4 22.5 15.0 36.2 16.0 14.0 56.8 5.9 60.3 12.1 26.8 6.3 17.7 30.8 38.5 40.6 13.9 36.2 21.3 10.7 14.5 14.5 23.6 21.2 9.2 14.1 4.6 12.9 72.2 7.9 18.0 9.4 20.1 11.5 37.8 14.8 74.4 24.2 20.8 12.3 8.0 21.6 32.6 29.1 14.9 49.2 9.7 16.7 3.6 5.4 63.1 17.9 14.0 3.6 1.6 3.7 0.8 1.1 1.0 0.2 0.7 1.1 0.5 1.4 0.5 0.8 8.1 0.6 3.9 1.0 1.5 0.6 119.3 103.4 104.6 110.9 106.6 107.0 118.5 127.8 118.3 124.9 132.1 95.0 38.7 22.4 19.2 16.3 9.1 15.7 36.0 7.9 10.8 50.1 31.5 24.4 1.1 37.1 9.2 44.1 37.5 26.3 9.2 107.4 80.3 24.0 77.7 22.3 16.1 48.5 20.0 56.0 27.2 28.0 31.8 27.4 12.2 26.4 0.0 36.7 84.3 110.5 23.7 28.6 24.4 30.2 12.2 27.1 16.3 151.4 35.4 22.7 21.4 25.3 10.1 69.7 12.3 8.5 14.3 56.6 67.9 56.8 27.0 67.5 66.9 109.2 7.6 69.0 85.5 30.9 32.2 120.8 24.6 19.3 24.0 34.2 10.6 34.2 24.4 47.9 PJA1 "FLJ11830, RNF70" ENSG00000181191 "Praja ring finger ubiquitin ligase 1" Q8NG27 X 69160851-69165521 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "epididymis: 160.0" "Cell type enhanced" "Detected in many" "Early spermatids: 74.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HAP1: 99.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000595 Approved Approved Nucleoplasm,Nucleoli NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 29: Early spermatids - Spermatogenesis" "Nucleoplasm, Nucleoli" "HPA000595: AB_1079826" "unprognostic (3.40e-2)" "unprognostic (2.28e-1)" "unprognostic (4.03e-2)" "unprognostic (2.58e-3)" "unprognostic (5.44e-2)" "unprognostic (1.30e-2)" "unprognostic (1.26e-3)" "unprognostic (4.61e-2)" "unprognostic (3.82e-3)" "unprognostic (1.84e-2)" "unprognostic (6.10e-2)" "unprognostic (1.60e-1)" "prognostic favorable (7.44e-5)" "unprognostic (1.49e-1)" "unprognostic (2.35e-1)" "unprognostic (2.01e-1)" "unprognostic (2.10e-1)" 22.9 14.5 46.8 8.7 50.5 3.6 19.4 37.2 78.0 19.9 33.0 15.4 6.4 16.4 160.0 12.3 16.0 11.1 15.0 47.1 48.9 19.2 9.4 13.8 10.0 38.9 41.7 25.8 14.5 38.7 28.1 17.3 40.6 15.3 7.6 17.6 10.6 32.4 7.9 14.6 11.1 16.0 40.1 13.3 14.0 26.4 49.0 10.0 22.7 8.8 12.1 17.4 15.1 43.5 27.3 19.6 62.9 43.7 21.3 22.5 18.7 17.8 22.0 16.7 22.3 17.1 25.8 4.4 26.7 28.1 39.2 24.0 99.0 34.9 21.2 20.2 33.0 8.1 16.0 10.9 25.7 4.9 14.4 23.1 23.6 28.6 17.0 15.8 19.0 13.2 7.8 3.0 16.9 14.1 2.1 8.4 43.4 23.1 32.0 20.0 28.2 6.9 23.4 22.6 46.4 30.7 28.6 4.9 22.2 50.1 7.7 7.0 17.8 13.9 22.6 41.7 8.3 0.0 0.2 9.1 15.3 13.1 19.4 6.6 6.8 2.1 29.6 9.2 34.3 16.4 26.1 27.5 7.3 22.8 26.5 31.3 2.3 30.0 6.5 8.9 17.5 19.4 46.8 50.5 37.2 78.0 47.1 48.9 38.9 41.7 40.6 40.1 49.0 43.5 4.7 16.0 4.8 2.9 9.7 41.0 19.4 30.8 23.9 16.8 5.0 6.2 7.1 4.3 14.8 3.7 8.4 35.6 5.9 1.0 15.6 24.9 74.7 3.9 10.4 6.6 5.4 10.8 8.1 11.7 15.3 18.2 7.1 5.8 4.5 27.9 6.8 1.7 7.0 5.0 8.3 3.6 6.1 2.9 9.9 32.7 27.1 5.7 5.4 2.8 2.9 30.6 14.4 5.0 3.7 18.0 1.7 19.5 7.7 17.0 0.5 6.5 4.4 6.1 6.6 9.4 16.3 1.4 1.5 11.2 29.5 20.8 11.2 27.0 2.6 22.5 PJA2 "KIAA0438, Neurodap1, RNF131" ENSG00000198961 "Praja ring finger ubiquitin ligase 2" O43164 5 109334713-109409974 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040347, HPA057636" Supported Enhanced "Intermediate filaments" No No "Cluster 14: Monocytes - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 30: Epithelial cell lines - Translation" "Cluster 43: Cardiomyocytes - Nuclear processes" "Intermediate filaments" "HPA040347: AB_10795631, HPA057636: AB_2683485" "unprognostic (5.78e-2)" "unprognostic (1.25e-1)" "unprognostic (5.48e-3)" "unprognostic (1.17e-1)" "unprognostic (2.99e-1)" "unprognostic (7.83e-2)" "unprognostic (2.83e-1)" "unprognostic (4.33e-2)" "unprognostic (4.84e-2)" "prognostic unfavorable (8.02e-4)" "unprognostic (4.46e-2)" "unprognostic (6.03e-2)" "unprognostic (5.64e-3)" "unprognostic (1.47e-3)" "unprognostic (5.94e-2)" "unprognostic (7.59e-2)" "unprognostic (1.00e-2)" 59.3 67.9 63.3 44.4 72.9 87.9 57.0 44.9 89.8 68.9 22.1 56.1 33.4 74.5 62.2 50.8 46.2 48.3 65.8 78.6 77.0 61.1 77.3 51.4 41.4 52.6 52.1 87.8 38.8 88.1 36.8 58.2 56.2 78.4 52.5 64.2 49.2 91.9 39.0 30.6 40.6 77.1 58.9 54.7 33.1 47.0 58.6 53.8 92.1 54.2 44.6 53.7 36.9 68.9 36.0 24.6 96.2 74.6 93.4 101.3 52.4 57.9 86.5 44.6 72.6 22.9 47.6 46.0 78.1 111.8 71.8 20.5 57.0 71.3 81.1 39.5 21.7 53.5 47.4 31.1 66.2 40.2 75.8 70.4 58.1 59.7 85.1 80.0 72.4 40.8 37.2 84.0 73.0 21.9 48.8 36.9 19.2 21.9 16.3 31.1 84.6 77.5 69.5 31.9 18.4 47.1 59.8 21.5 70.5 64.2 48.6 58.7 84.6 63.4 30.7 58.8 27.5 56.4 51.6 53.5 66.8 54.8 42.6 32.9 19.2 29.3 14.4 19.7 14.4 16.5 14.1 13.4 19.3 11.7 18.0 13.4 49.0 17.8 27.7 8.0 20.5 18.5 63.3 72.9 44.9 89.8 78.6 77.0 52.6 52.1 56.2 58.9 58.6 68.9 85.2 67.3 58.4 71.2 76.9 63.5 56.2 59.8 58.1 102.1 53.0 58.5 127.5 51.5 51.7 57.0 62.6 24.1 78.2 85.9 49.0 40.8 22.5 42.8 97.5 70.3 67.6 32.1 159.0 33.3 31.0 86.7 32.1 68.2 47.5 99.3 70.6 94.8 54.5 77.4 126.0 53.1 36.7 91.5 78.5 20.7 85.1 77.1 60.5 66.5 73.4 93.0 68.0 60.8 111.6 30.9 30.4 92.6 72.0 59.2 46.8 58.7 48.4 91.3 78.9 105.0 110.1 73.4 42.9 43.7 58.2 26.3 68.7 61.6 39.3 44.0 PKMYT1 "MYT1, PPP1R126" ENSG00000127564 "Protein kinase, membrane associated tyrosine/threonine 1" Q99640 16 2968024-2980479 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 27.6;testis: 56.9" "Cell type enhanced" "Detected in many" "Erythroid cells: 29.0;Extravillous trophoblasts: 52.0;Plasma cells: 22.9;Spermatocytes: 114.7;Spermatogonia: 46.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Immune cell enriched" "Detected in single" 6 "T-reg: 1.3" "Lineage enriched" "Detected in single" 6 "T-cells: 1.3" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA068860 Supported "Nucleoplasm,Nucleoli,Golgi apparatus" NA Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 23: Testis - Cell cycle regulation" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 12: Non-specific - Cell cycle regulation" "Golgi apparatus" "Nucleoplasm, Nucleoli" "HPA068860: AB_2686050" "unprognostic (7.82e-2)" "unprognostic (8.70e-2)" "unprognostic (5.93e-2)" "unprognostic (2.04e-2)" "unprognostic (4.54e-2)" "unprognostic (1.44e-1)" "prognostic unfavorable (8.33e-4)" "prognostic unfavorable (3.37e-4)" "unprognostic (4.52e-2)" "unprognostic (2.15e-1)" "unprognostic (1.61e-2)" "unprognostic (7.95e-3)" "unprognostic (0.00e+0)" "unprognostic (1.09e-3)" "unprognostic (9.13e-2)" "unprognostic (1.96e-1)" "unprognostic (5.91e-2)" 1.1 1.0 0.4 6.8 0.5 27.6 0.6 1.6 1.4 2.2 0.2 3.9 2.8 0.6 0.3 11.5 0.4 0.6 0.9 0.5 0.2 0.9 1.6 2.0 8.0 0.7 0.6 0.3 1.8 0.1 1.0 3.1 0.8 1.0 1.3 17.4 1.9 0.1 2.4 4.4 4.0 1.0 0.5 5.6 3.3 56.9 0.7 9.6 0.5 0.0 4.5 0.7 3.3 0.8 84.2 57.0 22.0 31.2 0.3 0.9 64.0 65.5 15.1 40.0 38.4 45.0 49.3 54.2 29.2 7.9 24.2 106.7 15.7 20.7 7.2 71.7 56.7 27.9 52.7 40.0 0.0 31.2 73.6 0.7 1.8 24.0 6.5 5.0 8.4 57.6 80.6 87.0 13.5 127.5 83.6 88.0 37.9 39.3 34.4 93.7 51.2 100.7 7.8 17.7 42.6 46.7 31.9 77.7 23.9 12.1 44.7 56.9 7.7 53.2 69.7 77.3 68.0 67.6 54.2 94.0 19.4 40.0 61.2 0.0 0.1 0.1 0.0 0.1 0.0 0.2 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 1.3 0.3 0.4 0.5 1.6 1.4 0.5 0.2 0.7 0.6 0.8 0.5 0.7 0.8 0.0 0.0 1.1 0.0 1.9 2.5 1.3 2.1 0.6 0.4 1.5 1.3 0.6 1.5 1.6 1.8 6.2 16.0 1.3 5.0 0.0 0.8 20.0 0.6 0.8 0.8 1.8 29.0 0.4 0.6 52.0 2.5 3.1 1.9 0.0 4.5 0.0 0.4 11.8 0.0 0.2 3.6 6.1 2.1 1.8 8.6 0.3 1.9 0.0 0.0 0.7 0.2 0.0 0.0 0.3 0.6 0.3 0.4 22.9 0.7 0.3 0.1 0.2 7.1 0.0 0.1 2.6 114.7 46.1 11.2 0.6 7.4 4.2 0.5 8.6 2.0 PKN1 "DBK, MGC46204, PAK1, PKN, PRK1, PRKCL1" ENSG00000123143 "Protein kinase N1" Q16512 19 14433053-14471867 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "NK-cells: 102.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003982, CAB010278" Approved Approved "Plasma membrane,Cytokinetic bridge" Yes NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 39: Non-specific - Mitochondria" "Cluster 24: NB-4 - Immune response" "Cluster 7: Non-specific - Mitochondria" "Plasma membrane" "Cytokinetic bridge" "CAB010278: AB_2163965, HPA003982: AB_1855440" "unprognostic (3.83e-2)" "unprognostic (2.14e-1)" "unprognostic (4.13e-2)" "unprognostic (1.13e-2)" "unprognostic (1.94e-1)" "unprognostic (4.58e-1)" "unprognostic (1.30e-2)" "unprognostic (1.45e-1)" "unprognostic (1.43e-1)" "unprognostic (8.55e-3)" "unprognostic (4.08e-3)" "unprognostic (2.11e-1)" "unprognostic (1.45e-2)" "unprognostic (1.70e-1)" "unprognostic (8.66e-2)" "unprognostic (4.08e-1)" "unprognostic (2.24e-2)" 59.2 45.1 47.1 40.4 50.3 66.8 49.0 44.6 52.4 46.6 44.2 72.4 14.5 61.0 13.6 16.2 48.7 23.9 89.0 40.9 46.3 43.1 25.0 71.1 49.4 53.6 48.4 38.7 52.5 32.8 44.9 33.3 49.8 43.8 9.3 11.5 41.3 30.6 81.7 20.1 45.2 33.0 49.8 90.4 51.4 50.2 49.2 35.6 39.6 53.8 25.8 60.3 32.8 48.5 152.8 88.9 32.3 67.8 51.3 59.8 53.0 53.5 63.5 55.2 52.5 34.9 84.2 144.4 135.0 92.2 68.9 34.4 52.1 23.8 21.2 117.6 67.7 172.8 55.4 75.2 169.1 68.2 103.9 43.3 17.0 33.5 52.2 62.5 129.8 74.9 78.0 96.7 41.4 62.5 104.1 63.2 59.2 54.7 100.0 138.5 43.9 104.7 27.3 24.2 117.3 166.0 33.2 41.7 88.9 15.5 37.8 117.7 196.6 108.8 46.1 133.2 82.8 126.5 123.6 78.9 71.5 135.7 87.4 27.6 27.9 40.6 30.4 38.5 23.3 15.9 20.5 21.1 26.8 16.9 18.6 21.0 32.6 22.1 52.3 17.0 25.7 29.0 47.1 50.3 44.6 52.4 40.9 46.3 53.6 48.4 49.8 49.8 49.2 48.5 78.1 3.2 2.2 17.3 35.3 3.7 6.4 1.9 1.8 37.2 17.6 14.7 4.0 27.1 3.1 35.0 16.7 2.8 77.9 4.9 1.9 28.2 4.9 27.0 25.4 49.4 40.2 17.7 3.6 30.1 14.5 20.8 30.1 20.7 2.5 80.9 53.2 11.3 59.8 48.8 8.6 10.9 8.2 69.0 17.0 8.4 19.9 56.2 17.8 17.8 48.2 61.2 102.0 7.5 11.9 64.2 10.6 23.0 27.1 12.7 1.1 15.2 12.4 29.2 26.3 21.7 29.2 9.3 42.2 1.3 2.7 3.7 55.5 34.3 4.8 4.9 PKN2 "Pak-2, PRK2, PRKCL2, STK7" ENSG00000065243 "Protein kinase N2" Q16513 1 88684222-88836255 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Cell adhesion, Cell cycle, Cell division, Cilium biogenesis/degradation, Host-virus interaction, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 5 "neutrophil: 80.5" "Lineage enriched" "Detected in all" 8 "granulocytes: 80.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034861, HPA057913" Approved Supported "Nucleoplasm,Nuclear bodies,Plasma membrane,Intermediate filaments,Centrosome,Cytosol" Yes No "Cluster 1: Neutrophils - Mixed function" "Cluster 34: Non-specific - Transcription" "Cluster 15: RT4 - Unknown function" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Intermediate filaments" "Nuclear bodies, Plasma membrane, Centrosome, Cytosol" "HPA034861: AB_2674363, HPA057913: AB_2732617" "unprognostic (7.52e-2)" "unprognostic (1.46e-1)" "prognostic favorable (5.67e-4)" "unprognostic (5.95e-2)" "unprognostic (3.39e-2)" "unprognostic (2.51e-2)" "unprognostic (4.64e-3)" "unprognostic (1.38e-1)" "unprognostic (4.43e-2)" "unprognostic (1.27e-2)" "unprognostic (2.90e-3)" "unprognostic (1.23e-1)" "unprognostic (1.51e-2)" "unprognostic (5.98e-2)" "unprognostic (2.38e-1)" "unprognostic (1.01e-2)" "unprognostic (1.99e-1)" 19.3 16.5 9.3 17.6 14.2 48.7 24.1 20.7 10.9 16.4 17.0 23.9 30.5 23.6 25.0 24.7 18.1 17.1 14.1 9.5 9.7 16.9 20.5 20.4 18.2 12.3 10.4 31.2 15.5 22.3 10.1 24.7 12.7 20.3 30.0 26.7 16.3 15.4 9.8 20.3 30.8 18.5 10.1 19.0 20.9 10.5 12.6 17.8 26.1 13.4 17.4 21.3 15.4 17.6 61.1 23.8 45.2 27.3 29.8 33.6 29.6 35.3 32.2 38.5 39.8 25.3 42.5 23.9 41.0 33.6 47.3 46.7 44.7 26.6 52.4 8.6 33.0 17.7 49.3 21.4 26.2 17.6 5.1 27.7 27.1 30.2 36.3 30.6 44.7 18.6 29.9 16.8 42.2 12.2 20.5 15.2 22.8 23.1 27.1 19.3 68.8 9.8 34.3 117.9 22.0 14.5 52.7 29.8 45.7 33.9 22.5 15.7 42.2 32.5 29.2 42.1 37.2 9.2 8.6 16.6 13.6 17.1 12.6 15.3 9.9 16.6 5.7 5.9 5.1 8.0 5.1 5.3 5.0 9.3 6.6 5.6 80.5 3.5 8.0 8.6 4.6 2.7 9.3 14.2 20.7 10.9 9.5 9.7 12.3 10.4 12.7 10.1 12.6 17.6 104.7 41.7 57.8 102.5 52.5 48.4 44.3 33.3 75.1 85.4 60.2 67.9 50.8 38.6 47.9 69.9 89.6 42.9 48.1 101.5 11.7 61.2 2.6 63.7 68.7 59.5 44.3 57.7 134.2 60.7 33.1 53.1 85.6 84.6 15.8 107.0 47.5 39.4 24.2 65.6 130.8 64.3 32.6 35.8 27.9 6.6 54.3 44.9 32.0 178.0 57.3 50.5 22.6 117.1 146.4 77.6 98.1 48.2 54.8 64.7 84.0 26.7 49.1 150.5 39.5 62.8 55.5 43.6 34.6 83.0 52.4 37.4 44.8 90.2 65.0 124.2 PKN3 "PKNbeta, UTDP4-1" ENSG00000160447 "Protein kinase N3" Q6P5Z2 9 128702503-128720916 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Adipocytes: 27.1;Breast glandular cells: 15.3;Endothelial cells: 17.9;Microglial cells: 13.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HeLa: 78.0;REH: 42.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA045390, HPA058305" Uncertain Approved Vesicles NA NA "Cluster 35: T-regs - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 20: HeLa - Mitochondria" "Cluster 30: Mammary glandular cells - Lactation" Vesicles "HPA045390: AB_2679308, HPA058305: AB_2683674" "unprognostic (4.36e-2)" "unprognostic (5.70e-2)" "unprognostic (2.68e-2)" "unprognostic (7.62e-2)" "unprognostic (2.23e-1)" "unprognostic (2.65e-2)" "unprognostic (6.10e-2)" "unprognostic (8.04e-2)" "unprognostic (1.78e-1)" "unprognostic (3.68e-1)" "unprognostic (1.48e-1)" "unprognostic (7.91e-2)" "unprognostic (8.73e-3)" "unprognostic (6.18e-3)" "unprognostic (9.99e-2)" "unprognostic (7.23e-2)" "unprognostic (2.36e-1)" 12.6 2.7 6.1 2.6 5.8 2.6 13.2 7.3 6.8 6.3 4.7 5.1 4.7 7.6 0.6 5.2 7.0 2.3 15.9 5.0 5.2 9.0 4.1 11.1 2.1 6.1 5.9 2.8 5.3 2.2 1.8 3.3 6.0 5.4 0.9 0.1 11.5 2.0 3.6 5.4 6.2 2.8 5.4 9.5 7.0 2.6 7.2 2.8 6.9 3.4 1.1 6.9 6.3 5.3 2.9 14.1 11.3 17.2 0.1 0.3 27.7 8.7 2.7 12.6 13.0 0.1 10.1 0.1 8.4 4.7 2.6 19.0 13.8 2.1 2.9 9.0 26.0 17.1 78.0 20.5 2.1 2.1 3.0 0.6 0.7 6.8 1.9 2.7 25.1 5.0 39.6 1.9 2.3 26.9 2.6 9.2 10.5 13.1 4.1 42.4 21.3 3.8 5.3 1.7 1.9 8.5 6.6 3.5 6.5 6.1 12.3 13.6 21.9 0.1 10.3 20.0 6.7 6.2 2.9 5.7 1.6 2.2 8.0 0.0 0.0 0.3 0.1 0.1 0.3 0.0 0.1 0.1 0.2 0.0 0.1 0.0 0.4 0.2 0.0 0.0 0.2 0.0 6.1 5.8 7.3 6.8 5.0 5.2 6.1 5.9 6.0 5.4 7.2 5.3 27.1 0.0 2.0 0.3 1.2 1.0 1.7 1.7 3.4 0.2 15.3 3.6 1.8 4.3 2.1 0.0 0.0 2.2 2.0 1.5 0.0 1.9 0.2 2.2 1.1 17.9 0.0 5.0 0.3 2.6 6.1 1.8 5.1 4.9 0.0 5.0 9.3 0.4 1.9 0.0 0.2 1.7 0.0 0.8 2.3 0.9 1.5 0.8 0.0 13.1 1.2 0.3 4.1 0.0 0.1 3.3 1.5 0.7 1.6 1.1 2.6 0.6 0.5 0.2 0.0 0.7 1.3 2.8 6.6 2.8 1.0 1.4 1.9 1.4 2.5 1.7 PLK1 PLK ENSG00000166851 "Polo like kinase 1" P53350 16 23677656-23690367 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 32.0;lymphoid tissue: 43.9;testis: 33.1" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 32.3;Early spermatids: 123.7;Erythroid cells: 38.3;Extravillous trophoblasts: 55.9;Spermatocytes: 79.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 5 "T-reg: 5.6" "Lineage enriched" "Detected in many" 5 "T-cells: 5.6" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" "HPA051638, HPA053229" Approved NA Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "HPA051638: AB_2681561, HPA053229: AB_2682084" "unprognostic (7.21e-3)" "unprognostic (1.77e-1)" "unprognostic (1.98e-3)" "unprognostic (4.97e-3)" "unprognostic (9.56e-2)" "unprognostic (5.12e-2)" "prognostic unfavorable (2.70e-7)" "prognostic unfavorable (2.28e-5)" "unprognostic (2.55e-2)" "unprognostic (1.89e-1)" "prognostic unfavorable (4.12e-4)" "unprognostic (1.24e-2)" "prognostic unfavorable (0.00e+0)" "unprognostic (1.33e-1)" "unprognostic (8.10e-2)" "unprognostic (1.19e-1)" "unprognostic (1.26e-2)" 1.4 1.5 2.3 13.4 2.3 32.0 1.5 2.5 3.2 2.3 2.0 9.6 10.4 1.2 0.4 13.9 1.0 1.4 1.0 2.3 2.1 1.4 1.9 1.9 27.8 2.3 2.3 1.3 1.1 0.2 1.2 6.4 2.2 1.2 10.1 1.2 2.4 0.3 1.0 5.7 9.2 4.0 2.0 9.1 6.2 33.1 2.5 43.9 0.9 0.4 30.0 2.8 4.0 2.8 199.9 207.5 166.2 90.9 5.2 11.7 92.8 111.0 74.5 172.5 127.0 184.3 131.0 99.1 56.3 76.5 90.1 112.8 229.5 93.5 206.1 139.5 128.0 125.2 163.4 257.1 1.7 147.5 133.7 4.8 5.2 124.7 125.2 21.6 127.9 127.5 200.7 133.9 134.8 187.8 139.8 151.4 189.5 82.1 103.5 217.2 111.7 160.0 49.3 43.9 94.3 65.3 126.8 88.9 55.8 94.4 114.4 92.1 65.1 82.7 102.7 79.9 194.1 93.2 156.8 173.6 69.3 127.7 137.2 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.8 0.3 0.3 0.0 0.0 0.0 0.4 0.9 0.0 0.0 5.6 1.4 2.3 2.3 2.5 3.2 2.3 2.1 2.3 2.3 2.2 2.0 2.5 2.8 0.6 3.2 0.0 3.3 7.6 1.3 1.2 6.5 0.0 1.4 1.7 2.3 0.6 0.0 1.4 0.0 4.2 32.3 0.4 5.5 0.0 0.8 123.7 3.4 1.3 2.5 0.0 38.3 3.1 0.8 55.9 4.7 10.2 1.8 1.3 19.9 3.3 1.1 20.8 0.0 2.3 7.3 4.1 6.9 3.2 13.9 1.2 7.2 0.0 2.8 0.4 1.1 0.0 1.5 2.3 1.2 0.3 0.7 23.0 2.0 1.5 0.1 1.3 1.3 0.0 2.3 6.1 79.5 13.5 12.2 1.8 3.8 2.5 1.2 17.9 2.0 PLK2 SNK ENSG00000145632 "Polo like kinase 2" Q9NYY3 5 58453982-58460139 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 380.7;Extravillous trophoblasts: 257.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 4 "NK-cell: 9.1" "Lineage enriched" "Detected in many" 4 "NK-cells: 9.1" "Cell line enhanced" "Detected in many" "hTERT-RPE1: 1060.6;T-47d: 396.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009624, HPA069329" Approved Approved Nucleoplasm,Mitochondria,Cytosol NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 7: Non-specific - Mitochondria" "Nucleoplasm, Mitochondria, Cytosol" "CAB009624: AB_2167745, HPA069329: " "unprognostic (4.82e-2)" "unprognostic (1.08e-2)" "unprognostic (2.38e-1)" "unprognostic (6.51e-2)" "prognostic unfavorable (7.75e-4)" "unprognostic (1.22e-1)" "unprognostic (2.55e-2)" "unprognostic (1.03e-2)" "unprognostic (2.44e-2)" "unprognostic (1.06e-2)" "unprognostic (1.01e-1)" "unprognostic (3.11e-1)" "prognostic unfavorable (2.08e-4)" "unprognostic (6.56e-2)" "unprognostic (1.43e-1)" "unprognostic (3.46e-1)" "unprognostic (1.95e-3)" 24.3 8.4 25.6 7.4 35.7 9.3 40.6 6.4 31.2 37.9 16.4 11.8 9.3 29.0 9.3 35.5 21.0 32.1 54.7 44.4 10.4 15.7 31.1 32.3 7.2 8.1 12.3 19.3 23.4 5.9 6.3 47.6 8.4 17.7 14.6 2.1 42.9 10.5 7.4 47.3 12.9 26.6 7.3 83.6 10.4 38.1 11.8 7.2 18.0 13.6 7.6 29.8 32.1 16.8 131.1 115.6 38.3 3.1 19.9 31.9 15.1 27.1 44.8 86.3 49.8 8.6 112.1 0.0 176.3 95.2 208.3 159.8 1.7 61.5 75.6 0.3 3.5 0.0 50.8 9.7 106.1 0.6 3.6 18.7 82.0 33.3 90.9 1060.6 175.4 0.0 0.1 4.4 169.8 47.5 0.3 0.2 7.6 12.4 18.5 6.3 106.5 0.0 221.6 25.4 2.3 5.1 82.4 16.0 76.0 66.1 396.9 2.0 231.9 24.3 63.8 11.0 217.8 0.1 0.3 0.3 18.8 0.3 110.7 2.2 0.5 1.9 0.1 1.2 0.0 0.8 0.5 0.0 2.2 0.6 0.9 0.4 1.5 9.1 0.5 1.5 0.4 0.4 25.6 35.7 6.4 31.2 44.4 10.4 8.1 12.3 8.4 7.3 11.8 16.8 144.6 19.2 15.8 5.9 23.4 141.7 194.1 116.1 380.7 3.8 108.5 203.7 128.9 30.0 134.9 18.4 4.2 66.5 22.7 66.3 9.8 109.8 10.9 132.7 67.8 178.7 84.3 2.7 44.3 77.9 257.3 107.8 136.6 165.4 9.5 4.1 89.3 7.7 14.9 0.0 22.8 39.9 124.1 8.1 19.3 5.0 12.8 39.5 24.9 15.9 3.2 3.3 0.0 3.5 4.9 103.2 44.6 10.9 8.2 76.1 38.5 5.5 31.6 2.9 0.0 74.0 106.6 65.1 10.4 184.9 103.4 129.8 21.2 7.4 45.6 63.1 PLK3 "CNK, FNK, PRK" ENSG00000173846 "Polo like kinase 3" Q9H4B4 1 44800377-44805990 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle, DNA damage" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Paneth cells: 116.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA060318 Enhanced NA NA "Cluster 35: T-regs - Unknown function" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 7: Non-specific - Mitochondria" "HPA060318: AB_2684252" "unprognostic (1.06e-1)" "unprognostic (8.71e-2)" "unprognostic (3.69e-2)" "unprognostic (3.51e-3)" "unprognostic (3.09e-2)" "unprognostic (4.72e-2)" "unprognostic (1.02e-1)" "unprognostic (1.59e-1)" "unprognostic (5.12e-3)" "unprognostic (6.78e-2)" "unprognostic (7.67e-3)" "unprognostic (2.79e-2)" "prognostic unfavorable (1.75e-4)" "unprognostic (2.04e-1)" "unprognostic (1.43e-1)" "unprognostic (5.06e-2)" "unprognostic (1.35e-1)" 13.6 6.4 3.2 10.7 3.6 13.8 8.9 4.0 5.3 8.7 8.1 4.9 3.3 8.1 2.8 19.2 7.4 17.3 6.3 3.6 6.0 5.8 7.1 12.9 9.0 9.3 7.1 6.6 8.9 7.1 7.5 6.7 6.7 5.6 2.9 0.4 6.7 3.3 2.8 16.1 6.5 4.9 5.8 7.7 5.4 2.1 5.4 5.4 7.3 2.4 5.8 18.0 8.7 7.2 7.2 4.1 6.6 3.4 4.7 15.0 12.3 15.7 20.8 5.9 5.8 2.5 9.9 8.1 6.5 12.9 18.7 6.5 3.7 21.4 3.2 13.5 0.7 9.1 2.6 6.2 22.5 2.9 11.7 11.8 12.3 17.4 16.1 20.0 17.8 3.0 4.9 3.6 13.0 4.6 6.2 2.7 4.5 4.0 5.5 7.8 4.3 13.3 20.3 2.4 5.0 3.2 4.5 8.3 17.6 10.1 0.6 2.8 23.3 3.6 9.4 7.5 9.7 9.5 4.7 2.8 8.0 5.2 7.2 0.0 4.0 1.0 1.9 5.9 2.1 1.4 11.6 4.7 5.0 1.2 12.4 5.8 4.7 0.8 6.3 2.0 14.0 4.4 3.2 3.6 4.0 5.3 3.6 6.0 9.3 7.1 6.7 5.8 5.4 7.2 55.7 12.8 35.1 1.3 32.2 44.1 60.5 23.3 32.5 7.1 58.4 33.7 3.4 32.9 15.8 5.5 2.1 19.0 32.2 77.7 0.0 18.3 0.8 41.9 27.6 43.5 53.0 2.7 3.6 13.0 22.9 36.7 109.6 67.5 78.7 12.0 32.5 6.7 36.9 6.7 6.3 53.0 2.0 37.7 60.3 0.7 9.9 72.5 12.4 10.3 9.8 7.4 1.0 1.5 2.0 24.3 116.8 5.3 31.4 25.8 47.3 3.3 14.7 10.2 26.3 58.5 30.5 2.5 4.5 37.2 33.5 59.2 65.2 17.0 46.3 58.9 PLK4 "Sak, STK18" ENSG00000142731 "Polo like kinase 4" O00444 4 127880893-127899224 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" Dwarfism "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "bone marrow: 22.6;lymphoid tissue: 14.4;testis: 22.6" "Cell type enhanced" "Detected in many" "Early spermatids: 65.9;Late spermatids: 87.5;Spermatocytes: 53.5" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017327, HPA035026, HPA043198" Approved Supported Centrosome,Cytosol NA NA "Cluster 35: T-regs - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "Centrosome, Cytosol" "HPA017327: AB_2669584, HPA035026: AB_10602080, HPA043198: AB_2732504" "unprognostic (2.44e-1)" "unprognostic (4.24e-2)" "prognostic favorable (7.46e-5)" "unprognostic (2.18e-1)" "unprognostic (3.79e-1)" "unprognostic (9.20e-2)" "unprognostic (1.06e-5)" "prognostic unfavorable (5.13e-4)" "unprognostic (1.44e-3)" "unprognostic (5.66e-2)" "prognostic unfavorable (5.14e-4)" "unprognostic (1.27e-1)" "unprognostic (2.22e-11)" "unprognostic (2.29e-2)" "unprognostic (3.58e-1)" "unprognostic (4.75e-2)" "unprognostic (7.93e-2)" 1.0 1.1 0.4 4.9 0.5 22.6 2.0 0.2 0.7 0.9 0.1 3.5 2.8 1.5 0.6 3.2 1.3 1.1 0.5 0.5 0.6 0.6 0.8 0.9 7.4 0.5 0.5 1.0 0.4 0.6 0.2 3.6 0.4 0.9 4.3 2.1 0.9 0.9 0.1 2.3 2.9 1.8 0.4 1.6 2.0 22.6 0.6 14.4 0.9 0.7 7.3 1.3 1.4 0.4 26.1 12.1 44.3 22.9 1.5 4.2 20.1 24.9 17.6 32.4 33.3 17.0 26.1 34.9 9.0 13.9 26.3 16.7 31.6 19.9 49.6 27.4 13.1 31.6 20.0 16.0 0.5 45.2 35.9 1.4 2.0 29.7 13.6 5.9 25.3 26.3 37.5 45.2 27.6 18.2 69.9 20.1 20.7 26.3 13.6 36.0 30.9 12.1 10.8 16.4 24.4 20.0 15.8 14.2 7.6 18.7 11.5 19.3 11.0 25.3 24.4 17.4 31.4 23.1 27.4 49.0 13.0 33.7 28.7 0.0 0.1 0.4 0.4 0.2 0.3 0.1 0.5 0.5 0.2 0.2 0.1 0.6 0.0 0.4 0.1 0.1 1.2 0.2 0.4 0.5 0.2 0.7 0.5 0.6 0.5 0.5 0.4 0.4 0.6 0.4 1.6 0.0 0.6 0.0 1.6 1.7 0.9 1.7 1.2 1.8 1.0 0.9 0.9 0.0 0.6 1.8 0.0 6.0 1.9 2.0 0.0 0.6 65.9 4.7 1.0 1.0 2.4 19.6 0.8 0.4 12.9 1.6 4.1 2.0 1.3 7.5 0.4 0.5 3.7 0.0 0.8 3.3 6.1 1.3 0.6 87.5 2.8 1.5 0.0 1.0 1.2 1.1 1.0 1.0 1.2 0.1 0.5 0.4 8.7 0.7 0.5 0.6 3.7 0.8 0.0 0.4 3.6 53.5 13.4 6.8 0.9 3.8 2.1 0.8 4.5 1.7 PLOD1 "LH1, LLH, PLOD" ENSG00000083444 "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1" Q02809 1 11934205-11975538 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Dioxygenase, Oxidoreductase" "Disease variant, Ehlers-Danlos syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 236.8;Sertoli cells: 105.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA049137, HPA055799" Uncertain Uncertain Nucleoplasm,Vesicles "Intracellular and membrane" NA NA 3600000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 15: Liver - Metabolism" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 38: Extravillous trophoblasts - Unknown function" Vesicles Nucleoplasm "HPA049137: AB_2680649, HPA055799: AB_2682924" "unprognostic (1.00e-1)" "unprognostic (2.69e-3)" "unprognostic (9.21e-3)" "unprognostic (5.43e-2)" "unprognostic (7.53e-3)" "unprognostic (1.12e-2)" "prognostic unfavorable (2.79e-4)" "unprognostic (1.13e-3)" "unprognostic (1.23e-1)" "unprognostic (1.79e-1)" "unprognostic (4.15e-3)" "unprognostic (2.32e-1)" "prognostic unfavorable (1.91e-12)" "unprognostic (2.79e-1)" "unprognostic (7.12e-2)" "unprognostic (5.92e-2)" "prognostic unfavorable (2.43e-4)" 58.1 34.6 46.3 35.2 51.2 16.1 41.2 48.6 56.6 65.4 46.4 47.3 37.7 65.0 30.5 21.3 51.1 42.0 71.2 44.5 47.4 45.5 78.1 44.4 15.4 49.6 50.8 54.4 39.0 36.9 29.6 83.8 52.4 34.7 23.2 10.6 75.9 40.6 40.5 27.2 35.6 78.4 44.8 31.5 35.5 11.6 52.2 7.9 34.9 41.6 12.9 42.4 36.0 53.1 112.5 91.4 51.3 239.7 343.4 190.6 39.0 330.4 436.1 170.4 287.1 105.2 71.5 63.1 339.5 367.3 125.9 93.4 75.6 115.6 115.6 66.2 78.3 34.0 136.6 137.3 212.5 21.9 162.7 234.0 59.7 206.2 81.9 573.3 305.0 14.8 97.6 30.9 180.2 71.1 5.7 58.6 22.9 115.4 131.6 25.8 100.0 141.0 98.7 24.3 19.2 77.7 137.3 97.4 164.8 80.4 48.3 55.9 298.7 190.1 141.6 236.3 161.9 71.4 123.7 38.7 425.1 75.5 316.8 0.0 40.3 2.0 17.3 34.4 3.1 1.7 3.0 8.4 32.7 3.4 1.2 6.4 35.5 5.4 32.3 4.9 2.0 22.6 46.3 51.2 48.6 56.6 44.5 47.4 49.6 50.8 52.4 44.8 52.2 53.1 19.4 0.0 7.9 9.4 3.7 7.0 8.0 22.8 8.0 5.7 17.9 17.5 18.3 8.6 8.6 11.0 2.1 39.7 8.7 14.8 3.9 30.3 1.0 11.0 62.2 33.9 8.4 3.0 4.2 9.8 236.8 47.5 17.3 24.8 0.0 20.4 36.8 37.1 46.3 6.7 5.8 12.5 4.1 26.5 8.3 2.4 44.4 16.3 10.6 15.9 17.9 7.9 15.5 3.0 9.8 22.4 15.4 24.5 19.4 8.0 41.5 16.7 4.5 3.1 105.2 77.2 47.3 0.5 3.3 7.4 5.1 33.7 5.5 37.1 16.6 3.9 PLOD2 LH2 ENSG00000152952 "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2" O00469 3 146069440-146163653 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Dioxygenase, Oxidoreductase" "Disease variant, Osteogenesis imperfecta" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 130.9;Basal respiratory cells: 115.1;Distal enterocytes: 143.7;Extravillous trophoblasts: 130.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HBF TERT88: 636.0;hTERT-RPE1: 723.8;U-87 MG: 566.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025898, HPA069126" Approved Uncertain Nucleoli,Cytosol "Intracellular and membrane" NA NA 21000 "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 33: Fibroblasts - ECM organization" "Nucleoli, Cytosol" "CAB025898: , HPA069126: " "unprognostic (8.68e-2)" "prognostic unfavorable (1.97e-4)" "unprognostic (2.23e-1)" "unprognostic (2.15e-1)" "unprognostic (1.34e-2)" "unprognostic (1.29e-3)" "prognostic unfavorable (7.64e-10)" "prognostic unfavorable (1.42e-4)" "unprognostic (2.97e-2)" "unprognostic (3.36e-2)" "unprognostic (6.27e-3)" "unprognostic (2.24e-1)" "prognostic unfavorable (4.99e-11)" "prognostic unfavorable (2.83e-4)" "unprognostic (6.07e-2)" "unprognostic (4.06e-2)" "unprognostic (4.41e-3)" 63.1 20.1 13.4 35.6 14.5 1.1 18.6 15.1 17.2 10.2 19.4 36.2 42.2 23.5 13.4 18.2 11.4 41.5 22.1 13.3 15.1 26.1 57.3 12.9 3.8 23.1 18.1 20.5 18.7 16.5 7.9 80.6 16.3 13.2 29.9 56.6 9.5 16.2 3.0 3.9 35.0 46.8 17.8 5.4 20.1 8.5 20.6 10.5 90.0 3.9 5.5 25.7 10.0 17.6 134.5 94.3 29.0 9.5 102.5 109.6 73.2 465.5 141.6 247.7 463.0 7.2 13.4 0.0 88.8 79.5 113.1 27.8 34.0 400.5 636.0 0.6 53.5 33.3 84.3 66.9 262.5 0.1 0.6 192.9 56.5 215.2 104.1 723.8 347.7 0.1 45.1 1.8 441.6 48.8 0.3 0.6 18.5 0.3 40.0 0.2 19.2 0.6 105.0 6.5 14.5 0.5 370.3 39.4 39.9 135.1 107.5 4.2 440.4 304.2 92.2 97.8 280.7 138.9 20.9 0.5 566.5 0.4 55.6 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 13.4 14.5 15.1 17.2 13.3 15.1 23.1 18.1 16.3 17.8 20.6 17.6 29.1 16.0 11.4 130.9 0.4 7.0 6.4 115.1 30.1 17.1 23.7 10.2 14.3 44.3 47.0 27.6 35.5 9.2 0.3 143.7 9.8 64.5 0.5 35.4 13.8 24.3 19.8 4.6 22.8 53.1 130.6 68.1 19.9 38.7 0.0 42.7 21.0 65.2 5.1 0.0 46.4 19.5 22.4 1.0 2.5 1.2 13.1 3.0 14.2 21.5 0.7 53.8 0.0 64.3 6.0 82.4 48.8 4.9 1.3 8.9 50.5 8.2 33.0 24.7 19.7 36.9 47.2 11.0 18.0 27.5 5.5 18.7 1.0 24.5 25.1 5.6 PLOD3 LH3 ENSG00000106397 "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3" O60568 7 101205977-101218420 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Dioxygenase, Glycosyltransferase, Multifunctional enzyme, Oxidoreductase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Cancer enhanced" "Detected in all" "melanoma: 115.2" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in all" 4 "dendritic cells: 20.3;monocytes: 22.5;T-cells: 12.6" "Cell line enhanced" "Detected in all" "Karpas-707: 695.6;WM-115: 680.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001236 Uncertain "Secreted to extracellular matrix" NA NA 1600000 "Cluster 39: Non-specific - mRNA processing" "Cluster 15: Liver - Metabolism" "Cluster 2: Karpas-707 - Immune response" "Cluster 38: Extravillous trophoblasts - Unknown function" "HPA001236: AB_1855474" "unprognostic (1.15e-1)" "prognostic unfavorable (1.91e-5)" "prognostic unfavorable (3.26e-4)" "unprognostic (1.39e-1)" "unprognostic (2.76e-3)" "unprognostic (1.04e-2)" "unprognostic (6.26e-3)" "unprognostic (1.11e-3)" "unprognostic (8.00e-3)" "unprognostic (1.18e-2)" "unprognostic (4.18e-2)" "unprognostic (1.66e-1)" "unprognostic (1.21e-3)" "unprognostic (1.68e-1)" "unprognostic (1.54e-1)" "unprognostic (8.52e-3)" "unprognostic (9.87e-2)" 41.9 27.3 43.6 22.9 53.2 19.6 32.8 54.9 58.5 33.3 46.8 37.8 25.7 38.9 11.7 12.2 32.5 18.8 42.6 43.6 46.3 36.3 54.1 37.5 14.6 61.1 52.3 26.3 41.8 21.5 27.1 35.0 58.9 24.2 15.3 3.9 19.4 18.6 15.3 19.1 35.9 26.0 49.4 35.3 30.0 12.9 51.7 8.0 25.3 11.8 7.5 35.2 25.2 71.9 71.7 62.4 27.1 168.2 116.2 83.9 51.4 125.5 135.9 122.7 88.6 98.0 89.0 5.6 140.2 211.4 100.7 83.0 50.0 72.0 31.2 37.8 23.8 7.2 70.7 97.3 157.6 31.5 57.4 90.8 67.6 71.6 55.4 120.2 110.9 4.6 68.4 695.6 84.2 194.5 3.4 72.1 53.5 120.5 94.9 21.8 35.1 108.3 42.0 19.1 21.2 116.0 81.1 116.2 288.1 66.8 21.9 105.2 100.5 188.1 94.9 228.1 155.0 38.5 75.9 5.2 112.4 74.2 680.2 0.0 18.1 4.4 12.6 21.8 10.9 3.7 9.3 8.3 16.5 2.2 4.1 4.5 1.8 3.6 22.5 20.3 6.7 9.5 43.6 53.2 54.9 58.5 43.6 46.3 61.1 52.3 58.9 49.4 51.7 71.9 34.1 22.4 8.7 11.1 9.7 8.9 10.8 18.9 8.0 5.7 8.1 9.1 16.1 21.5 8.7 25.8 14.6 20.4 22.0 37.6 1.9 40.2 0.6 10.8 29.9 28.5 16.2 19.1 11.9 31.6 71.6 34.2 17.9 20.5 19.7 25.9 26.7 18.3 50.1 8.4 10.8 18.0 4.1 23.3 18.3 2.1 26.1 23.2 62.2 4.7 18.9 7.7 12.3 10.1 33.4 36.1 37.8 14.7 19.7 8.0 45.8 8.8 9.3 7.3 19.7 14.3 29.8 8.9 12.4 1.9 4.8 18.9 12.5 18.4 27.3 5.2 PNCK "CaMK1b, MGC45419" ENSG00000130822 "Pregnancy up-regulated nonubiquitous CaM kinase" Q6P2M8 X 153669733-153689010 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 65.1;intestine: 81.7" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 40.9;Excitatory neurons: 29.0;Extravillous trophoblasts: 63.9;Granulosa cells: 46.9;Syncytiotrophoblasts: 49.5" "Cancer enhanced" "Detected in many" "renal cancer: 15.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 9 "AN3-CA: 33.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007458 Approved Approved "Golgi apparatus,Plasma membrane,Cytosol" NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 40: Granulosa cells - Unknown function" "Plasma membrane" "Golgi apparatus, Cytosol" "HPA007458: AB_1079644" "unprognostic (1.56e-1)" "unprognostic (2.56e-1)" "unprognostic (1.16e-2)" "unprognostic (5.95e-3)" "unprognostic (1.83e-2)" "unprognostic (3.98e-2)" "unprognostic (2.15e-4)" "unprognostic (1.72e-1)" "unprognostic (1.08e-1)" "unprognostic (1.46e-2)" "unprognostic (3.60e-1)" "unprognostic (1.27e-1)" "prognostic unfavorable (1.04e-6)" "unprognostic (2.86e-3)" "unprognostic (1.43e-1)" "unprognostic (2.66e-1)" "unprognostic (6.26e-3)" 1.6 1.2 43.7 1.9 48.8 0.0 0.6 6.5 53.3 1.3 4.8 81.7 3.4 6.5 1.7 14.0 4.1 2.6 6.5 49.8 40.8 1.9 0.2 0.6 0.0 19.6 22.8 0.9 0.3 0.5 1.8 2.0 21.1 17.2 3.8 7.9 0.4 37.6 2.0 1.8 13.4 15.7 15.0 0.2 15.9 8.8 65.1 1.4 0.3 0.3 0.1 27.4 2.2 28.5 0.3 0.1 0.4 33.9 0.0 0.0 3.4 0.3 0.3 0.0 0.0 0.0 0.2 0.0 1.0 0.0 0.2 0.4 0.5 0.0 0.0 0.0 3.9 0.0 0.0 0.5 0.2 0.0 0.1 0.1 0.0 0.0 0.0 1.6 0.0 0.3 0.4 0.3 0.2 0.7 0.0 0.0 0.9 0.3 0.0 0.0 0.0 0.0 0.1 0.1 0.2 3.7 0.0 0.1 2.7 0.9 0.3 0.4 0.0 0.2 1.2 0.0 0.2 0.2 0.0 0.2 0.5 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 43.7 48.8 6.5 53.3 49.8 40.8 19.6 22.8 21.1 15.0 65.1 28.5 0.0 0.0 0.0 18.9 0.0 0.6 0.4 40.9 0.0 21.6 0.3 0.9 3.0 0.0 18.0 0.0 22.9 13.5 0.1 1.7 0.0 0.4 0.3 0.3 4.4 0.3 0.0 0.0 29.0 0.4 63.9 0.5 0.0 0.3 0.0 46.9 0.0 0.0 2.4 0.0 24.2 1.1 12.2 0.0 0.0 0.8 0.0 0.3 1.8 1.0 0.0 3.2 0.0 11.1 13.2 2.9 0.1 0.4 0.0 0.3 20.3 0.4 2.6 19.4 0.0 0.0 4.0 0.6 0.9 0.0 0.6 49.5 0.1 0.6 0.4 1.0 PNKP PNK ENSG00000039650 "Polynucleotide kinase 3'-phosphatase" Q96T60 19 49859882-49878351 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair" "Hydrolase, Kinase, Multifunctional enzyme, Transferase" "Disease variant, Epilepsy, Mental retardation, Neurodegeneration, Primary microcephaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006782 Supported Supported Nucleoplasm,Nucleoli NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 18: Non-specific - Mitochondria" "Cluster 15: RT4 - Unknown function" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Nucleoli" "HPA006782: AB_1855496" "prognostic favorable (9.18e-4)" "unprognostic (1.87e-1)" "unprognostic (4.31e-2)" "unprognostic (4.23e-1)" "unprognostic (1.00e-1)" "unprognostic (4.40e-2)" "unprognostic (1.08e-2)" "unprognostic (1.24e-1)" "unprognostic (3.36e-1)" "unprognostic (1.58e-1)" "unprognostic (3.71e-2)" "unprognostic (1.70e-1)" "unprognostic (4.55e-2)" "unprognostic (3.00e-2)" "unprognostic (2.82e-1)" "unprognostic (7.24e-2)" "unprognostic (3.68e-3)" 18.9 45.1 12.0 21.0 12.9 26.4 21.2 12.8 16.2 21.1 24.2 21.6 16.0 21.3 13.5 19.4 22.9 10.6 23.9 14.4 11.9 27.3 22.4 22.2 17.5 14.0 14.0 23.7 28.6 16.7 36.8 11.1 14.3 25.3 13.1 10.1 21.6 12.4 18.5 17.8 22.8 11.5 12.8 37.2 25.0 21.2 13.3 12.3 31.9 7.8 15.3 19.4 18.0 14.1 27.5 17.4 19.1 27.2 15.8 13.4 28.6 43.4 21.2 18.7 17.7 17.5 34.2 18.4 13.6 13.6 11.3 23.5 6.1 25.9 10.9 22.3 27.2 30.0 36.7 14.8 12.2 25.8 36.3 13.2 13.0 17.9 11.0 16.9 26.3 23.4 14.9 34.3 24.7 18.8 28.7 23.5 16.0 28.3 37.4 24.3 15.9 34.7 21.0 68.5 20.6 33.4 19.3 52.5 9.2 14.5 10.2 14.8 36.0 37.6 24.9 9.6 35.8 38.7 16.5 13.0 33.8 12.3 30.8 1.8 12.3 16.7 9.2 11.5 7.9 9.1 7.8 7.3 9.8 12.2 5.7 5.0 23.4 3.9 18.1 5.5 9.1 5.8 12.0 12.9 12.8 16.2 14.4 11.9 14.0 14.0 14.3 12.8 13.3 14.1 23.6 16.0 23.6 5.9 47.2 13.4 35.4 29.9 25.6 40.9 28.1 23.7 11.1 21.5 19.1 20.2 81.3 44.5 37.7 40.0 23.5 42.5 15.0 25.2 28.5 26.6 30.5 17.1 6.0 39.9 35.1 19.1 31.6 28.0 29.1 54.6 35.0 20.1 39.5 33.7 6.0 31.7 24.4 27.7 19.0 32.9 59.4 26.8 14.2 8.4 46.1 18.4 96.8 6.0 5.7 44.6 22.3 44.8 40.4 33.6 27.1 36.1 33.8 73.9 19.7 17.9 20.1 19.4 28.9 23.3 13.1 49.3 39.2 83.0 34.1 35.6 POR "CYPOR, FLJ26468" ENSG00000127948 "Cytochrome p450 oxidoreductase" P16435 7 75899200-75986855 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" Oxidoreductase "Congenital adrenal hyperplasia, Craniosynostosis, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 313.3" "Cell type enhanced" "Detected in all" "Hepatocytes: 489.2;Proximal enterocytes: 274.2;Theca cells: 647.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SK-BR-3: 328.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004372, HPA010136" Enhanced Approved Nucleoplasm,Vesicles,Cytosol NA NA 12000 "Cluster 5: Granulocytes - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Nucleoplasm, Vesicles" Cytosol "CAB004372: AB_627391, HPA010136: AB_1079657" "unprognostic (1.89e-1)" "unprognostic (1.53e-1)" "unprognostic (2.81e-3)" "unprognostic (8.67e-2)" "prognostic unfavorable (8.54e-4)" "unprognostic (1.65e-1)" "unprognostic (1.17e-2)" "unprognostic (4.32e-2)" "unprognostic (1.69e-2)" "unprognostic (1.46e-1)" "unprognostic (1.22e-1)" "unprognostic (2.58e-1)" "unprognostic (1.11e-1)" "unprognostic (9.31e-2)" "unprognostic (1.71e-1)" "unprognostic (3.94e-2)" "unprognostic (9.89e-2)" 53.4 197.4 19.9 32.1 20.7 17.9 44.7 14.1 18.6 42.0 15.5 35.9 105.2 32.1 29.4 53.6 50.2 37.0 43.3 20.7 30.2 38.1 313.3 55.0 19.9 22.2 24.5 52.2 44.5 77.6 71.4 46.3 20.9 31.8 21.9 12.7 29.9 113.1 56.2 43.8 92.4 28.2 16.9 43.8 41.5 25.5 34.7 38.0 131.3 68.1 23.2 36.6 42.3 15.3 59.6 133.0 57.0 106.3 212.9 79.8 98.0 24.4 79.3 44.7 62.3 100.7 257.0 56.1 21.9 53.1 151.8 28.3 76.0 38.4 19.6 48.1 57.9 26.0 36.9 189.4 146.5 26.2 45.5 163.9 47.4 59.2 43.2 36.3 42.3 27.1 79.1 24.0 40.8 90.9 29.0 49.4 71.7 92.9 74.8 41.0 37.6 61.1 50.0 72.8 59.3 57.4 65.4 328.4 91.0 32.6 94.0 44.2 38.6 41.7 45.8 63.6 48.7 23.8 38.3 39.0 59.3 39.8 54.9 65.9 42.6 60.4 20.6 39.6 17.1 11.0 17.5 19.4 45.6 11.2 17.1 14.7 53.8 25.9 30.2 12.5 19.3 36.6 19.9 20.7 14.1 18.6 20.7 30.2 22.2 24.5 20.9 16.9 34.7 15.3 34.3 38.5 39.7 23.2 17.1 17.1 29.4 172.3 13.1 31.4 20.5 14.0 10.9 54.3 201.4 73.5 12.5 99.9 26.0 97.7 1.9 65.0 27.6 62.1 28.0 27.1 19.8 11.8 10.1 29.4 95.0 40.1 67.8 46.6 24.7 121.4 32.2 489.2 67.8 15.2 17.1 41.7 124.1 35.2 16.1 9.5 75.8 47.3 12.4 11.2 20.5 25.9 12.3 11.6 8.8 27.9 102.0 112.5 17.0 20.7 274.2 31.7 178.6 23.0 65.7 32.7 46.9 21.3 30.8 18.2 14.6 193.2 25.4 647.6 44.5 45.9 PPARA "hPPAR, NR1C1, PPAR" ENSG00000186951 "Peroxisome proliferator activated receptor alpha" Q07869 22 46150521-46243756 "FDA approved drug targets, Metabolic proteins, Nuclear receptors, Predicted intracellular proteins, Transcription factors" "Biological rhythms, Transcription, Transcription regulation" "Activator, DNA-binding, Receptor" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "tongue: 44.6" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 99.4;Hepatocytes: 144.5;Proximal enterocytes: 93.2;Rod photoreceptor cells: 148.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "eosinophil: 10.3;plasmacytoid DC: 3.1" "Group enriched" "Detected in many" 5 "dendritic cells: 3.1;granulocytes: 10.3" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA058901, HPA067049, CAB075701" Supported Enhanced Nucleoplasm NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 3: HMC-1 - Innate immune response" "Cluster 46: Photoreceptor cells - Phototransduction" Nucleoplasm "CAB075701: , HPA058901: AB_2683849, HPA067049: AB_2685770" "unprognostic (1.96e-1)" "unprognostic (2.19e-1)" "unprognostic (1.02e-1)" "unprognostic (4.76e-2)" "unprognostic (3.94e-3)" "unprognostic (4.30e-2)" "unprognostic (1.24e-1)" "unprognostic (4.94e-2)" "unprognostic (2.95e-1)" "unprognostic (5.52e-3)" "unprognostic (4.50e-2)" "unprognostic (1.01e-1)" "prognostic favorable (4.39e-9)" "unprognostic (4.84e-2)" "unprognostic (2.76e-1)" "unprognostic (1.23e-1)" "unprognostic (3.18e-2)" 7.9 6.3 9.6 4.5 12.7 6.6 3.8 9.5 6.9 4.1 23.5 11.8 18.4 3.8 3.6 7.7 4.1 4.4 26.3 7.7 8.8 22.4 33.2 4.0 3.4 11.0 11.2 11.2 8.2 7.4 2.6 4.3 10.0 6.2 9.1 18.2 7.8 5.7 26.2 7.7 18.4 4.3 8.6 4.4 6.1 1.3 11.7 3.7 7.0 44.6 3.9 5.1 4.0 10.5 7.8 1.9 2.4 8.4 13.0 8.3 5.3 6.7 13.2 7.0 7.2 3.8 3.7 2.8 3.3 15.6 6.5 3.5 7.1 8.7 6.3 8.1 8.9 8.7 4.8 8.0 8.1 6.0 14.3 6.6 6.9 5.2 11.8 6.0 1.5 6.3 3.2 6.4 6.6 2.0 6.8 2.2 0.3 6.5 1.9 8.0 8.6 3.6 4.7 4.6 2.4 7.0 2.6 2.4 8.0 3.2 2.7 4.6 2.6 7.3 7.7 6.7 2.9 6.3 4.0 1.2 11.4 6.6 2.3 1.4 0.8 10.3 1.0 1.0 0.8 0.8 0.5 0.5 0.6 1.0 0.6 0.4 0.7 0.7 0.7 3.1 1.4 0.2 9.6 12.7 9.5 6.9 7.7 8.8 11.0 11.2 10.0 8.6 11.7 10.5 15.0 3.2 13.6 49.6 8.0 23.3 15.0 7.8 9.1 15.0 14.3 11.4 99.4 22.8 8.9 7.3 62.6 8.0 18.4 58.8 9.8 10.3 0.6 9.4 26.4 15.5 19.9 32.0 1.4 16.6 6.7 16.0 14.8 18.4 5.1 19.1 22.5 144.5 8.8 5.0 13.8 31.4 0.0 24.8 10.2 1.1 19.6 10.4 3.6 10.3 12.2 16.0 8.2 19.6 27.2 13.0 24.5 30.1 10.6 19.1 93.2 40.8 5.0 148.0 6.6 31.0 15.8 0.7 1.7 19.3 34.2 3.0 9.6 14.6 37.9 19.9 PPEF1 "PPEF, PPP7CA" ENSG00000086717 "Protein phosphatase with EF-hand domain 1" O14829 X 18675909-18827921 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "brain: 5.8;testis: 14.6" "Group enriched" "Detected in some" 9 "Early spermatids: 64.0;Late spermatids: 139.0" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 1.1;HeLa: 1.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA034577 Uncertain "Plasma membrane,Cytokinetic bridge" Yes NA "Cluster 78: Testis - Spermatogenesis" "Cluster 20: HeLa - Mitochondria" "Cluster 31: Spermatids - Spermatogenesis" "Plasma membrane" "Cytokinetic bridge" "HPA034577: AB_10602817" "unprognostic (4.13e-2)" "unprognostic (1.30e-1)" "unprognostic (9.06e-2)" "unprognostic (9.85e-2)" "unprognostic (3.84e-2)" "unprognostic (5.00e-2)" "unprognostic (2.38e-1)" "unprognostic (3.43e-2)" "unprognostic (4.96e-3)" "unprognostic (9.29e-2)" "unprognostic (1.70e-1)" "unprognostic (2.89e-1)" "unprognostic (1.10e-11)" "unprognostic (5.41e-3)" "unprognostic (2.75e-1)" "unprognostic (2.97e-2)" "unprognostic (1.19e-2)" 0.1 0.2 1.3 0.0 2.0 1.0 2.3 1.8 2.6 0.1 0.8 0.1 0.0 0.1 0.5 0.0 0.1 0.1 0.3 1.6 1.4 0.2 0.1 0.3 0.1 3.5 2.1 0.2 0.1 0.0 0.5 0.6 2.4 0.4 0.0 1.4 0.1 0.3 0.1 0.4 0.1 0.0 1.8 0.2 0.1 14.6 1.5 0.1 0.2 0.0 0.1 0.2 0.1 5.8 0.0 1.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.4 0.0 1.5 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.9 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 2.0 1.8 2.6 1.6 1.4 3.5 2.1 2.4 1.8 1.5 5.8 0.0 0.0 0.0 1.3 0.0 0.1 0.0 0.0 0.0 0.4 0.1 0.0 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 64.0 0.0 0.0 0.1 0.0 0.0 11.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 6.7 4.7 0.0 0.0 0.0 0.3 139.0 0.6 0.0 3.6 1.0 0.1 0.6 0.0 0.5 2.2 0.0 0.0 0.7 0.0 0.1 0.0 0.2 0.0 0.6 0.0 0.0 1.2 1.2 1.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 PPEF2 PPP7CB ENSG00000156194 "Protein phosphatase with EF-hand domain 2" O14830 4 75859864-75902571 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Sensory transduction, Vision" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 462 "retina: 238.7" "Group enriched" "Detected in some" 25 "Cone photoreceptor cells: 166.8;Rod photoreceptor cells: 576.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 46: Photoreceptor cells - Phototransduction" "unprognostic (3.19e-2)" "unprognostic (2.92e-1)" "unprognostic (2.50e-1)" "unprognostic (4.73e-2)" "unprognostic (1.53e-1)" "unprognostic (9.02e-2)" "unprognostic (3.32e-4)" "unprognostic (2.74e-2)" "unprognostic (4.54e-8)" "unprognostic (2.89e-1)" "unprognostic (5.98e-2)" "unprognostic (5.16e-1)" "unprognostic (3.66e-3)" 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.2 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 238.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 11.4 0.1 0.1 0.4 0.0 0.0 0.0 166.8 0.0 0.1 0.1 0.0 0.0 6.3 0.0 0.1 1.5 0.0 0.0 1.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 5.3 0.0 0.1 0.0 1.9 0.1 14.7 0.0 0.5 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 576.7 0.0 0.4 0.1 0.6 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 PPIA CYPA ENSG00000196262 "Peptidylprolyl isomerase A" P62937 7 44796680-44824564 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Apoptosis, Host-virus interaction" "Isomerase, Rotamase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "CAB004655, HPA058345" Uncertain "Secreted to blood" NA NA 230000000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 32: Non-specific - Translation" "CAB004655: AB_425607, HPA058345: AB_2683685" "unprognostic (3.10e-1)" "unprognostic (2.28e-1)" "unprognostic (1.27e-1)" "unprognostic (7.86e-2)" "unprognostic (9.27e-2)" "unprognostic (2.19e-2)" "prognostic unfavorable (2.27e-6)" "unprognostic (1.12e-3)" "unprognostic (3.30e-2)" "unprognostic (3.92e-2)" "unprognostic (8.68e-3)" "unprognostic (2.52e-1)" "unprognostic (6.35e-3)" "unprognostic (2.77e-1)" "unprognostic (1.24e-1)" "unprognostic (7.84e-2)" "unprognostic (1.16e-1)" 1148.4 1085.6 1707.2 714.4 1757.6 1052.9 1368.0 1733.9 2245.6 943.7 1718.8 1352.6 603.7 854.8 981.6 2149.0 771.3 548.8 781.6 1785.4 1791.4 1412.8 1318.6 1099.2 1067.1 1857.4 1728.1 799.5 967.7 1286.3 670.1 805.9 1860.7 766.1 1196.0 496.7 1020.3 782.9 566.1 1516.0 953.4 943.4 1767.2 1134.4 896.7 366.0 1742.4 2333.2 884.9 517.9 1647.3 1339.3 1208.7 1822.8 2141.8 3020.1 3731.1 2509.6 2798.6 4154.8 1115.0 3173.6 4588.0 5531.3 5393.2 3414.3 3127.1 4614.1 1893.1 3828.8 6554.2 3209.5 4495.7 5727.5 5062.6 2674.3 3204.3 1883.6 3911.6 4682.5 2255.3 3890.0 2246.2 3103.5 3820.5 3988.9 4295.5 2888.1 5717.2 3277.9 3933.2 3789.6 5790.6 3665.7 4667.5 7562.4 4612.9 7628.9 3689.2 3554.4 2050.1 5969.7 8018.9 4215.4 2548.3 2218.7 2500.5 7185.8 2493.3 4091.8 4303.8 5202.3 2587.0 2865.0 3656.5 2027.1 4050.5 3861.7 6522.3 9409.0 2614.0 4314.6 4455.2 475.6 1239.3 594.8 1421.6 1449.2 1534.2 2104.8 1500.3 1491.1 2196.1 1769.5 1217.2 1394.4 133.3 1349.0 1374.8 2618.5 2085.4 3631.4 1707.2 1757.6 1733.9 2245.6 1785.4 1791.4 1857.4 1728.1 1860.7 1767.2 1742.4 1822.8 713.8 794.9 759.9 37.2 1037.1 866.6 867.8 1097.5 1878.1 94.3 1226.2 1628.0 47.6 526.1 743.6 603.2 18.8 852.7 1067.7 658.4 1414.6 1172.4 78.2 539.3 770.8 719.7 529.6 1120.3 57.3 1218.7 1683.7 672.4 820.1 862.1 622.1 650.0 669.7 766.9 1582.1 111.0 50.4 1003.5 587.9 1110.0 786.1 81.4 582.2 988.1 691.9 41.2 1283.2 221.6 995.9 27.2 79.8 1222.6 715.0 613.1 1215.3 922.1 831.6 1636.8 481.4 101.5 394.4 588.7 942.7 366.7 246.1 2608.3 990.4 609.2 924.5 1157.5 1262.6 947.0 PPIAL4A "COAS2, PPIAL4, PPIAL4B" ENSG00000263353 "Peptidylprolyl isomerase A like 4A" Q9Y536 1 120889746-120890405 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Isomerase, Rotamase" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at transcript level" "Evidence at protein level" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 9 "Distal tubular cells: 1.9" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "Karpas-707: 1.6;NB-4: 1.8;SK-BR-3: 1.9" HPA058345 Uncertain NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 39: Non-specific - Basic cellular processes" "HPA058345: AB_2683685" "unprognostic (3.49e-3)" "unprognostic (2.78e-2)" "unprognostic (1.45e-1)" "unprognostic (1.42e-1)" "unprognostic (4.17e-1)" "unprognostic (1.77e-1)" "unprognostic (2.09e-1)" "unprognostic (1.42e-2)" "unprognostic (7.94e-3)" "unprognostic (1.72e-2)" "unprognostic (1.91e-1)" "unprognostic (7.11e-2)" "unprognostic (5.32e-2)" "unprognostic (3.66e-2)" "unprognostic (1.55e-1)" "unprognostic (1.83e-2)" "unprognostic (1.74e-1)" 0.0 0.2 0.0 0.2 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.6 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.4 0.3 0.0 0.0 0.1 0.7 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 1.6 0.1 0.4 0.8 1.8 1.0 0.0 0.0 0.3 0.6 0.8 0.0 0.0 0.4 0.1 0.1 1.9 0.2 0.0 1.3 1.1 0.3 1.2 0.4 1.2 0.7 0.5 0.4 1.0 1.1 0.7 1.3 0.0 0.4 0.2 0.4 0.4 0.4 0.8 0.6 0.7 0.9 0.6 0.4 0.7 0.0 0.7 0.3 0.9 0.7 1.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PPIAL4C ENSG00000263464 "Peptidylprolyl isomerase A like 4C" A0A0B4J2A2 1 149583865-149584464 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Isomerase, Rotamase" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in some" "intestine: 3.4;lymphoid tissue: 2.2" "Cell type enriched" "Detected in single" 5 "Cardiomyocytes: 1.7" "Not detected" "Not detected" "Not detected" "Not detected" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "NB-4: 18.8;THP-1: 22.5" HPA058345 Uncertain NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 14: B-cells - Humoral immune response" "Cluster 43: THP-1 - Innate immune response" "Cluster 43: Cardiomyocytes - Nuclear processes" "HPA058345: AB_2683685" "unprognostic (3.16e-1)" "unprognostic (2.83e-2)" "unprognostic (1.50e-2)" "unprognostic (7.93e-2)" "unprognostic (5.98e-2)" "unprognostic (1.37e-1)" "unprognostic (1.79e-1)" "unprognostic (6.61e-2)" "unprognostic (2.25e-1)" 0.3 1.9 0.5 2.2 0.5 0.2 0.4 0.7 0.9 0.4 0.4 0.8 3.4 0.9 0.0 0.1 0.1 0.1 0.0 0.5 0.5 0.7 0.3 1.0 2.1 0.5 0.5 0.2 0.0 0.2 0.2 0.8 0.5 0.4 0.2 0.0 0.0 0.1 0.5 0.3 1.8 0.1 0.4 1.7 0.8 0.0 0.5 0.0 0.1 0.0 0.8 0.1 0.1 0.5 4.1 0.0 0.5 3.2 0.2 0.5 2.8 0.5 0.2 1.2 0.9 0.0 6.4 1.9 2.4 0.0 3.1 4.5 0.0 0.3 0.8 4.8 0.0 0.4 0.0 0.0 0.1 1.1 1.7 0.2 1.0 0.8 0.4 0.0 0.0 0.2 0.9 6.1 0.9 0.7 7.4 18.8 7.6 0.8 0.1 7.2 0.1 12.2 0.0 0.0 5.0 6.8 0.8 13.1 7.9 0.0 6.1 22.5 0.0 4.4 6.1 3.2 10.5 4.4 6.9 11.9 5.0 5.8 9.8 1.6 3.8 1.6 4.1 5.2 4.8 7.0 4.6 4.5 8.0 6.2 3.8 5.0 0.3 3.3 3.6 8.3 6.1 12.0 0.5 0.5 0.7 0.9 0.5 0.5 0.5 0.5 0.5 0.4 0.5 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PPIAL4E ENSG00000271567 "Peptidylprolyl isomerase A like 4E" A0A075B759 1 144372875-144373659 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Isomerase, Rotamase" "Evidence at transcript level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Evidence at transcript level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA058345 Uncertain NA NA "Cluster 43: Cardiomyocytes - Nuclear processes" "HPA058345: AB_2683685" "unprognostic (6.97e-2)" "unprognostic (5.22e-2)" "unprognostic (2.28e-1)" 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.6 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.3 0.0 0.2 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.6 0.3 0.2 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 PPIAL4G ENSG00000236334 "Peptidylprolyl isomerase A like 4G" P0DN37 1 148482548-148483302 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Isomerase, Rotamase" "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "Evidence at transcript level" "Tissue enhanced" "Detected in some" "brain: 1.5" "Cell type enhanced" "Detected in some" "Basal keratinocytes: 6.8;Langerhans cells: 7.4;NK-cells: 9.2;Suprabasal keratinocytes: 12.5" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "HL-60: 1.9;TIME: 1.9" HPA058345 Uncertain NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 6: Brain - Smell perception" "Cluster 20: HeLa - Mitochondria" "Cluster 63: NK-cells & T-cells - Immune response" "HPA058345: AB_2683685" "unprognostic (2.17e-3)" "unprognostic (3.63e-1)" "unprognostic (4.83e-1)" "unprognostic (2.26e-1)" "unprognostic (2.37e-1)" "unprognostic (2.11e-1)" "unprognostic (3.95e-1)" "unprognostic (2.67e-2)" "unprognostic (1.79e-1)" 0.1 0.5 0.7 0.5 0.4 1.0 0.1 1.5 0.7 0.0 0.1 0.2 0.7 0.1 0.4 0.0 0.0 0.0 0.1 0.4 0.3 0.3 0.1 0.3 0.7 0.2 0.3 0.3 0.1 0.1 0.0 0.0 0.3 0.3 0.1 1.1 0.4 0.0 0.9 0.7 0.7 0.0 0.1 0.4 0.4 0.4 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.6 0.8 0.9 0.1 1.0 0.0 0.0 0.0 0.2 0.2 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.4 0.6 0.7 0.0 1.9 0.9 0.0 0.0 0.0 0.0 0.5 0.0 0.5 0.4 1.1 0.0 0.3 0.0 0.9 0.4 0.5 0.1 0.0 0.0 0.0 0.3 0.0 0.1 0.2 0.8 1.4 0.2 0.6 0.9 0.0 1.9 0.2 1.1 1.2 0.3 1.1 0.8 0.9 0.0 0.5 0.4 0.2 0.2 0.5 1.2 0.4 0.7 1.2 0.8 0.7 0.4 0.8 0.6 0.7 0.0 2.2 1.7 0.3 1.1 0.6 0.7 0.4 1.5 0.7 0.4 0.3 0.2 0.3 0.3 0.1 0.5 0.6 0.1 0.0 0.6 0.0 1.0 6.8 0.4 0.8 0.0 1.8 0.3 0.4 0.1 0.0 0.1 0.0 0.0 0.0 0.9 0.1 0.0 0.1 1.4 0.1 0.2 0.5 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.4 1.3 0.1 0.4 0.5 0.2 1.7 0.0 0.0 0.0 1.2 7.4 0.3 0.0 0.2 1.8 0.0 0.4 0.2 9.2 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.0 0.0 0.1 1.1 0.0 0.5 2.6 0.0 0.1 0.0 12.5 0.1 3.2 0.1 0.0 0.2 PPIB "B, CYP-S1, CYPB, OI9, PPIase, SCYLP" ENSG00000166794 "Peptidylprolyl isomerase B" P23284 15 64155740-64163134 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Isomerase, Rotamase" "Disease variant, Dwarfism, Osteogenesis imperfecta" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 1473.7;Plasma cells: 2242.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011487, HPA012720" Enhanced Supported "Nucleoplasm,Endoplasmic reticulum" "Secreted to blood" No No 33000000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 25: RPMI-8226 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" "Endoplasmic reticulum" Nucleoplasm "CAB011487: AB_443295, HPA012720: AB_1847399" "unprognostic (3.00e-3)" "unprognostic (5.65e-3)" "unprognostic (2.81e-1)" "prognostic favorable (1.56e-5)" "unprognostic (1.65e-1)" "unprognostic (1.07e-3)" "unprognostic (3.69e-2)" "unprognostic (1.27e-2)" "unprognostic (7.19e-2)" "unprognostic (8.80e-3)" "unprognostic (2.87e-1)" "unprognostic (2.79e-2)" "prognostic unfavorable (2.02e-11)" "unprognostic (7.05e-2)" "unprognostic (3.77e-2)" "unprognostic (1.82e-1)" "unprognostic (3.90e-2)" 375.5 377.5 230.7 449.5 240.3 571.9 361.9 247.9 259.2 611.5 257.2 401.0 365.0 383.9 899.0 298.8 401.5 379.2 262.0 229.7 256.9 312.3 737.4 351.1 344.5 258.1 241.4 386.2 644.2 345.4 416.8 515.2 255.1 375.7 411.3 72.3 513.1 488.6 62.2 205.5 334.3 482.4 247.0 360.5 375.0 110.0 254.9 315.6 672.8 91.1 346.4 510.9 295.6 262.6 675.6 847.9 736.7 1666.7 2577.0 1492.3 641.9 1570.3 2108.3 1248.7 1472.3 1242.6 1223.1 653.6 1227.4 2513.0 1235.3 1067.7 1384.6 1080.4 641.1 406.2 491.0 914.5 915.3 1643.7 2682.9 915.0 778.1 1374.2 1149.4 725.9 1751.3 1516.7 1539.2 301.1 645.9 2174.7 966.0 1102.6 280.6 1404.9 625.1 1879.0 529.5 520.6 784.1 3347.9 1312.7 1062.6 410.5 647.7 726.0 1224.5 1194.2 1086.0 727.6 2767.0 927.6 1213.7 975.8 679.2 1079.4 1152.5 1269.5 693.4 1129.0 1478.0 1238.2 716.7 712.5 491.7 929.6 547.3 931.8 827.8 645.0 762.4 930.9 541.4 411.3 558.0 347.5 668.1 369.3 2643.5 569.3 1512.3 230.7 240.3 247.9 259.2 229.7 256.9 258.1 241.4 255.1 247.0 254.9 262.6 389.3 125.0 209.0 16.6 375.3 160.2 426.2 614.6 234.5 34.5 264.3 303.8 0.8 270.2 328.7 272.2 31.3 625.9 560.0 271.0 90.1 665.1 19.0 295.8 910.1 285.0 297.0 172.6 10.2 566.4 1473.7 627.8 441.4 494.2 181.2 540.4 322.7 473.2 630.1 45.4 15.8 603.9 205.4 216.9 333.4 29.5 456.3 316.6 281.1 19.7 299.1 149.1 368.7 35.2 37.0 435.1 338.9 393.1 2242.6 569.3 338.6 287.4 168.2 43.7 230.1 204.3 445.6 38.4 76.6 337.0 144.8 1118.9 352.3 674.0 477.2 422.3 PPIC CYPC ENSG00000168938 "Peptidylprolyl isomerase C" P45877 5 123023250-123036725 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Isomerase, Rotamase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 251.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 229.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039163 Approved "Intracellular and membrane" NA NA 3700000 "Cluster 46: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 33: Fibroblasts - ECM organization" "HPA039163: AB_2676374" "unprognostic (7.81e-2)" "unprognostic (1.44e-1)" "unprognostic (3.28e-2)" "unprognostic (7.44e-2)" "unprognostic (2.03e-1)" "unprognostic (7.49e-2)" "prognostic unfavorable (4.78e-4)" "unprognostic (1.39e-1)" "unprognostic (1.37e-2)" "unprognostic (3.88e-3)" "unprognostic (1.67e-1)" "unprognostic (1.31e-1)" "unprognostic (3.37e-1)" "unprognostic (1.70e-1)" "unprognostic (2.38e-1)" "unprognostic (4.27e-2)" "unprognostic (2.43e-2)" 37.0 20.6 5.3 16.4 5.6 0.2 30.4 6.8 7.0 42.3 12.2 41.4 37.3 31.0 36.5 46.8 14.8 33.5 44.4 5.2 5.8 24.9 28.9 27.0 7.6 6.4 6.3 16.2 30.3 20.9 6.2 48.3 6.2 23.4 49.9 4.9 31.7 24.0 41.2 20.2 32.3 45.2 6.1 7.7 22.4 9.0 6.7 5.8 47.2 33.3 14.2 45.8 28.8 5.8 19.6 16.8 6.4 136.2 229.7 104.6 26.9 54.4 42.3 27.8 56.7 28.1 128.6 0.0 94.2 147.1 83.3 21.9 18.9 68.6 22.1 0.1 33.1 27.8 60.7 32.8 58.9 0.0 14.7 65.8 51.5 32.5 34.0 49.9 58.1 0.0 7.9 0.0 20.1 116.5 0.1 0.3 11.6 120.9 29.0 0.0 14.5 0.0 87.7 67.0 8.5 14.9 106.7 51.1 12.1 77.8 72.0 61.8 64.8 52.9 32.7 18.5 23.9 0.2 0.1 0.4 45.9 0.2 37.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.3 5.6 6.8 7.0 5.2 5.8 6.4 6.3 6.2 6.1 6.7 5.8 214.1 32.1 16.5 6.2 1.6 47.4 52.3 251.7 30.7 16.9 63.9 47.5 46.4 61.5 149.0 73.5 4.2 60.1 0.6 134.0 29.4 201.5 1.7 52.4 94.8 106.5 12.7 0.0 0.8 126.4 65.2 198.2 55.0 50.8 1.3 54.2 80.7 57.8 43.2 0.0 2.2 177.1 207.5 4.2 40.3 4.2 112.5 6.9 32.0 5.6 3.2 2.8 0.0 1.0 0.3 90.3 181.0 100.1 0.6 48.2 189.0 81.7 110.5 4.4 39.5 22.7 87.5 41.6 37.8 118.6 49.3 25.0 3.4 61.2 117.0 81.5 PPID CYP-40 ENSG00000171497 "Peptidylprolyl isomerase D" Q08752 4 158709127-158723396 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Protein transport, Transport" "Chaperone, Isomerase, Rotamase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019520, HPA019692" Approved Supported "Nucleoplasm,Nucleoli,Nucleoli rim,Cytosol" NA NA 480000 "Cluster 2: Granulocytes - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 44: HDLM-2 - Immune response" "Cluster 10: Non-specific - Unknown function" Cytosol "Nucleoplasm, Nucleoli, Nucleoli rim" "HPA019520: AB_1847400, HPA019692: AB_1847401" "unprognostic (4.26e-2)" "unprognostic (2.03e-2)" "unprognostic (8.91e-3)" "unprognostic (8.17e-3)" "unprognostic (1.50e-1)" "unprognostic (2.04e-3)" "unprognostic (4.72e-2)" "unprognostic (1.62e-2)" "unprognostic (4.72e-2)" "unprognostic (5.92e-2)" "unprognostic (4.54e-2)" "unprognostic (1.46e-2)" "unprognostic (2.66e-3)" "unprognostic (8.78e-2)" "unprognostic (1.74e-1)" "unprognostic (1.64e-1)" "unprognostic (1.09e-1)" 26.8 38.3 38.0 24.4 40.2 25.1 22.8 40.4 77.6 25.4 46.4 33.9 50.6 24.2 19.0 27.7 24.1 18.8 49.6 40.1 44.2 39.5 87.6 19.8 28.6 39.0 39.4 24.2 31.7 17.0 28.6 21.6 40.2 23.5 20.3 36.2 23.3 18.7 88.9 36.1 45.3 18.9 39.6 29.1 29.0 24.1 42.2 24.3 23.9 45.5 25.8 27.4 24.0 46.9 46.7 42.3 41.8 57.7 60.7 45.2 63.1 44.9 24.3 40.3 30.4 55.4 30.9 48.9 19.7 42.0 63.4 35.1 127.9 51.5 48.8 162.9 44.4 87.5 36.5 76.9 46.8 55.6 63.0 28.9 41.2 34.6 51.5 52.0 44.6 81.9 111.0 84.4 45.5 44.6 80.0 49.9 57.9 75.5 55.8 35.9 20.7 41.7 44.6 23.0 70.2 47.1 33.8 69.2 65.6 60.0 31.9 52.2 43.7 40.1 45.3 44.7 60.2 48.3 107.2 62.0 51.1 59.4 41.1 68.8 23.9 55.2 31.1 35.4 36.0 22.3 30.2 29.1 26.4 25.4 30.9 32.0 32.9 40.5 37.7 26.9 37.0 28.0 38.0 40.2 40.4 77.6 40.1 44.2 39.0 39.4 40.2 39.6 42.2 46.9 29.2 6.4 13.4 13.1 24.8 10.1 29.7 17.5 9.1 30.2 19.1 20.8 59.7 25.8 27.9 27.6 22.9 41.5 38.7 17.1 37.2 39.2 39.0 66.1 39.9 25.1 19.6 17.4 24.3 23.0 49.5 24.3 14.3 28.5 32.3 24.4 17.2 18.5 41.9 75.7 28.6 28.3 22.4 17.0 14.7 23.1 20.5 26.0 14.2 9.4 51.6 23.3 48.4 15.1 28.3 29.5 27.4 22.6 22.3 31.6 39.7 33.7 62.3 32.3 6.6 17.7 58.2 96.0 77.5 16.9 11.8 47.6 33.7 33.7 32.0 20.2 PPIE "CyP-33, MGC111222, MGC3736" ENSG00000084072 "Peptidylprolyl isomerase E" Q9UNP9 1 39692182-39763914 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "mRNA processing, mRNA splicing" "Isomerase, RNA-binding, Rotamase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in some" "HPA019357, HPA020131" Approved Supported "Nuclear speckles" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 72: Non-specific - Transcription" "Cluster 43: THP-1 - Innate immune response" "Cluster 31: Spermatids - Spermatogenesis" "Nuclear speckles" "HPA019357: AB_2670131, HPA020131: AB_1847405" "unprognostic (2.94e-1)" "unprognostic (4.32e-2)" "unprognostic (6.34e-2)" "unprognostic (6.97e-2)" "unprognostic (5.99e-2)" "unprognostic (8.41e-2)" "prognostic unfavorable (1.76e-4)" "unprognostic (3.52e-2)" "unprognostic (2.69e-1)" "unprognostic (3.88e-3)" "unprognostic (1.25e-1)" "unprognostic (9.29e-2)" "prognostic unfavorable (5.05e-5)" "unprognostic (5.86e-2)" "unprognostic (3.95e-1)" "unprognostic (9.06e-2)" "unprognostic (1.00e-1)" 26.0 27.9 22.3 16.1 22.9 18.5 26.8 22.7 26.5 31.4 20.2 41.1 18.3 33.8 24.9 31.8 35.0 18.1 33.3 22.3 22.8 33.0 33.7 23.3 27.2 22.6 22.0 36.7 40.2 23.8 27.7 20.7 22.9 32.3 22.5 20.9 26.2 23.6 43.1 29.5 29.2 25.4 23.7 32.7 31.7 41.8 22.3 20.6 29.1 30.3 28.2 36.4 29.5 24.6 24.5 34.4 37.2 25.7 40.9 36.9 14.3 40.8 42.7 58.7 56.4 32.8 64.8 68.4 52.2 47.9 34.5 32.8 57.1 52.3 68.8 41.1 38.4 75.6 37.4 9.7 50.9 68.4 36.3 32.8 47.2 53.9 21.0 42.0 54.5 52.8 74.8 39.5 46.6 24.7 34.2 42.1 39.9 49.7 31.5 41.4 28.4 38.4 37.8 37.2 47.7 42.3 43.8 31.5 28.4 49.7 40.9 155.8 35.8 36.3 35.3 48.4 57.1 55.8 66.4 52.5 27.0 86.4 52.3 38.3 62.8 32.6 83.9 64.8 82.8 107.5 89.4 83.8 74.1 109.2 103.5 82.4 6.0 123.2 70.0 63.8 101.3 122.5 22.3 22.9 22.7 26.5 22.3 22.8 22.6 22.0 22.9 23.7 22.3 24.6 28.2 32.1 36.7 10.7 37.0 24.9 43.1 69.8 23.9 25.9 30.3 47.5 31.8 21.5 62.1 33.1 14.6 62.5 39.3 22.8 66.5 57.5 29.2 34.6 27.7 28.7 28.8 38.3 7.7 48.4 59.3 34.0 16.3 23.4 55.2 44.1 37.9 31.1 56.1 23.5 8.8 32.9 40.7 33.4 26.9 76.3 29.8 30.0 39.2 8.4 46.8 34.0 58.7 8.0 13.6 40.0 24.1 45.1 31.7 32.0 39.3 69.8 63.4 29.7 59.2 23.3 40.1 76.1 51.4 24.5 26.3 34.8 36.6 36.3 35.9 32.9 PPIF "Cyp-D, hCyP3" ENSG00000108179 "Peptidylprolyl isomerase F" P30405 10 79347469-79355334 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Necrosis" "Isomerase, Rotamase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Langerhans cells: 370.9;Macrophages: 160.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 75.0" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA077416 Supported Mitochondria NA NA 320000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 1: K-562 - Erythropoiesis" "Cluster 41: Macrophages - Immune response" Mitochondria "HPA077416: AB_2686840" "unprognostic (2.21e-1)" "unprognostic (5.48e-2)" "unprognostic (1.68e-1)" "unprognostic (1.72e-3)" "unprognostic (1.69e-1)" "unprognostic (3.16e-3)" "unprognostic (3.45e-1)" "unprognostic (4.33e-3)" "unprognostic (1.66e-1)" "unprognostic (1.97e-1)" "unprognostic (2.82e-1)" "unprognostic (9.37e-3)" "unprognostic (1.02e-3)" "unprognostic (1.23e-1)" "unprognostic (1.66e-1)" "unprognostic (1.69e-3)" "unprognostic (4.88e-2)" 62.7 227.7 42.7 42.8 48.4 168.8 42.4 57.9 69.6 27.6 63.7 50.0 36.3 14.0 7.2 66.0 22.9 19.5 119.1 38.1 45.2 63.3 174.9 29.1 32.3 49.0 56.2 19.3 86.9 77.6 18.3 27.1 48.8 18.8 52.4 8.9 39.5 45.5 99.5 71.9 31.3 21.0 50.6 58.7 98.2 35.0 57.1 28.3 26.0 133.6 55.5 60.0 35.1 60.8 220.4 90.6 62.3 123.5 57.0 73.6 79.8 124.2 161.2 265.7 249.6 213.5 102.7 224.8 68.0 87.4 188.6 127.8 195.3 115.4 410.5 72.2 186.4 352.8 87.5 380.7 96.4 245.7 80.4 173.2 81.3 264.5 262.3 86.5 47.5 86.4 351.6 268.3 91.6 111.7 64.1 204.2 53.0 99.6 500.6 109.8 96.4 114.7 103.9 200.0 124.1 92.0 63.6 253.8 97.9 40.5 111.4 187.2 43.5 116.1 106.3 137.9 242.0 124.7 137.7 181.9 114.5 313.9 32.0 15.2 34.3 18.0 10.4 27.5 10.9 19.1 9.1 9.6 43.3 7.7 8.1 7.9 75.0 9.0 10.4 5.4 10.0 16.6 42.7 48.4 57.9 69.6 38.1 45.2 49.0 56.2 48.8 50.6 57.1 60.8 8.4 6.4 6.8 7.2 32.7 42.6 30.2 23.8 31.3 4.0 41.8 40.8 124.6 14.3 14.4 12.9 6.2 99.4 26.4 39.9 92.0 42.1 14.5 12.4 24.0 10.1 21.6 37.0 4.1 28.0 127.1 25.1 78.0 15.5 13.4 73.4 6.1 98.5 91.1 8.4 5.7 69.5 18.3 40.3 370.9 14.1 6.2 160.8 35.6 4.7 32.0 13.0 5.2 5.5 15.0 39.8 26.6 6.0 48.7 41.4 21.3 41.2 12.6 5.2 19.7 18.2 28.6 14.8 22.5 52.9 37.6 142.3 23.9 60.2 81.1 34.2 PPIG "CARS-Cyp, SCAF10, SRCyp" ENSG00000138398 "Peptidylprolyl isomerase G" Q13427 2 169584342-169641406 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Isomerase, Rotamase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021788, HPA057469" Supported Supported "Nuclear speckles,Cytosol" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 1: K-562 - Erythropoiesis" "Cluster 10: Non-specific - Unknown function" "Nuclear speckles" Cytosol "HPA021788: AB_1847408, HPA057469: AB_2683445" "unprognostic (2.70e-1)" "unprognostic (2.17e-1)" "unprognostic (2.40e-1)" "unprognostic (2.04e-3)" "unprognostic (4.17e-2)" "unprognostic (3.49e-2)" "unprognostic (1.55e-3)" "unprognostic (3.66e-2)" "unprognostic (2.15e-3)" "unprognostic (3.15e-3)" "unprognostic (2.47e-2)" "unprognostic (2.28e-1)" "prognostic unfavorable (4.56e-4)" "unprognostic (5.23e-2)" "unprognostic (3.29e-1)" "unprognostic (3.41e-2)" "unprognostic (3.39e-2)" 26.0 23.2 23.1 28.4 22.1 54.2 27.5 28.8 58.6 27.6 22.9 26.3 26.6 28.8 31.5 27.5 23.6 22.0 25.6 21.5 29.9 29.2 47.1 24.7 36.9 24.6 25.6 26.5 21.2 32.6 25.8 28.0 24.3 27.9 26.0 29.3 26.5 22.9 27.6 25.4 29.7 21.7 22.9 32.3 27.4 20.1 23.7 36.1 29.9 26.2 35.4 26.3 26.5 25.9 56.4 25.5 70.8 35.9 35.4 42.5 63.7 58.9 42.3 45.0 45.9 66.3 58.9 94.8 52.5 44.1 55.5 50.5 56.6 48.4 65.6 68.0 45.7 129.9 36.7 88.3 34.4 136.8 58.9 36.6 54.0 58.5 64.6 40.6 50.4 53.5 142.7 76.2 49.5 43.5 101.0 81.9 100.8 45.3 25.1 90.7 71.7 90.5 53.9 81.2 60.5 41.2 63.4 47.2 68.9 52.9 44.2 78.7 52.7 53.9 43.7 38.4 52.6 41.1 65.3 126.8 38.5 68.1 54.1 31.9 22.5 36.7 22.8 25.1 26.7 32.9 30.9 29.2 18.2 38.4 33.4 27.6 40.4 21.1 31.4 30.0 26.8 17.0 23.1 22.1 28.8 58.6 21.5 29.9 24.6 25.6 24.3 22.9 23.7 25.9 159.7 221.2 175.1 53.5 188.8 151.4 191.4 185.9 101.3 204.6 120.8 156.1 148.4 107.2 169.5 93.8 54.2 170.0 160.1 91.6 80.3 103.1 11.0 104.6 142.3 141.1 104.8 163.5 82.4 103.3 177.0 142.4 66.8 126.3 179.1 115.8 121.7 181.2 151.7 220.4 81.8 135.8 116.0 130.3 126.5 15.6 142.0 129.6 110.3 46.9 152.4 137.6 133.9 53.8 69.7 93.9 118.0 146.7 130.1 161.8 121.1 113.8 132.2 109.1 164.3 150.2 193.9 276.4 183.8 108.3 172.8 205.5 166.7 147.1 149.9 167.7 PPIH "CYP-20, CYPH, MGC5016, SnuCyp-20, USA-CYP" ENSG00000171960 "Peptidylprolyl isomerase H" O43447 1 42658335-42676758 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "mRNA processing, mRNA splicing" "Chaperone, Isomerase, Rotamase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA059019 Approved NA NA "Cluster 44: Non-specific - Transcription" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 43: THP-1 - Innate immune response" "Cluster 10: Non-specific - Unknown function" "HPA059019: AB_2683885" "unprognostic (7.93e-3)" "unprognostic (5.49e-3)" "unprognostic (2.53e-2)" "unprognostic (6.42e-2)" "unprognostic (3.79e-2)" "unprognostic (1.95e-2)" "prognostic unfavorable (1.55e-5)" "unprognostic (1.09e-1)" "unprognostic (2.37e-2)" "unprognostic (1.82e-2)" "unprognostic (2.84e-2)" "unprognostic (3.40e-2)" "prognostic unfavorable (1.78e-9)" "unprognostic (6.59e-3)" "unprognostic (4.93e-1)" "unprognostic (2.41e-1)" "unprognostic (1.52e-1)" 22.9 23.2 22.1 27.8 23.1 56.8 27.7 23.7 29.5 24.8 20.8 33.2 24.4 23.5 25.4 36.4 23.5 17.9 25.8 23.0 22.5 22.1 17.5 22.4 44.5 22.2 22.0 25.8 19.2 18.3 13.4 24.7 22.7 21.2 32.8 22.4 23.9 18.3 19.8 27.5 27.8 21.5 21.8 32.3 23.4 22.9 22.5 60.3 26.0 21.1 50.4 26.6 25.8 23.3 105.8 66.4 80.1 113.3 24.9 51.5 101.4 67.6 50.1 127.4 114.4 98.1 111.8 171.5 85.9 52.8 61.7 82.3 150.8 108.2 133.9 150.2 119.7 156.4 104.4 98.6 21.4 322.0 90.7 31.2 57.5 117.9 90.6 49.1 60.6 161.2 205.7 91.7 63.8 84.2 250.1 451.0 200.4 100.4 77.7 136.8 150.2 152.2 64.1 64.8 59.2 113.5 59.6 101.1 77.4 100.8 54.5 465.0 48.1 53.2 143.1 77.0 171.7 60.0 140.2 319.6 62.8 294.9 94.8 29.7 15.1 33.3 35.0 23.5 33.3 33.6 35.7 39.9 20.7 32.9 36.1 43.5 3.6 36.4 21.8 25.9 38.2 25.0 22.1 23.1 23.7 29.5 23.0 22.5 22.2 22.0 22.7 21.8 22.5 23.3 31.3 19.2 20.7 9.8 48.1 28.9 48.2 51.7 38.7 10.0 30.1 44.4 14.1 11.5 25.8 22.0 4.2 62.5 37.7 15.7 45.0 29.4 33.2 23.4 27.4 25.1 21.5 49.8 12.7 26.4 104.5 25.5 27.5 21.6 31.0 46.9 19.2 11.2 52.1 5.0 9.6 27.3 34.6 18.6 25.6 7.3 29.2 28.5 16.0 9.4 26.2 22.2 52.5 11.6 11.6 25.8 17.6 21.4 45.6 28.0 16.1 34.1 19.6 16.1 19.7 21.5 42.0 19.7 32.3 54.6 21.5 37.9 42.7 46.4 40.0 38.7 PPIL1 CYPL1 ENSG00000137168 "Peptidylprolyl isomerase like 1" Q9Y3C6 6 36854827-36874803 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "mRNA processing, mRNA splicing" "Isomerase, Rotamase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 58.7;Extravillous trophoblasts: 72.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA062916 Supported Nucleoli NA NA 21000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 38: Extravillous trophoblasts - Unknown function" Nucleoli "HPA062916: AB_2684904" "unprognostic (3.51e-2)" "unprognostic (2.33e-1)" "unprognostic (2.64e-3)" "unprognostic (1.11e-2)" "unprognostic (1.87e-1)" "unprognostic (1.81e-2)" "prognostic unfavorable (1.28e-5)" "unprognostic (2.01e-1)" "unprognostic (3.37e-2)" "prognostic favorable (4.90e-4)" "unprognostic (6.58e-2)" "unprognostic (5.49e-2)" "unprognostic (8.99e-2)" "unprognostic (1.30e-1)" "unprognostic (2.30e-1)" "unprognostic (3.39e-2)" "unprognostic (2.15e-2)" 12.4 21.7 20.3 19.1 21.9 11.4 18.4 22.6 27.3 15.0 23.8 14.7 13.2 15.7 19.1 17.0 23.0 10.7 42.8 20.0 25.2 18.9 21.5 10.5 21.9 22.0 22.0 17.7 14.3 21.7 12.0 22.3 23.3 16.8 17.6 29.1 19.5 17.6 18.5 9.5 11.3 22.9 24.1 9.5 12.9 23.2 22.2 18.6 33.2 20.7 24.6 20.5 8.0 22.8 69.2 50.0 111.2 78.5 19.7 31.5 77.5 60.9 41.0 82.7 70.0 89.7 39.7 87.7 75.5 41.9 105.5 55.4 135.1 92.7 96.2 81.3 114.6 102.7 33.6 147.7 53.5 89.3 40.8 24.7 48.7 62.3 118.9 31.8 75.5 79.1 202.4 48.0 63.3 71.2 101.9 69.8 92.3 108.5 57.9 79.4 100.2 92.0 63.2 53.5 140.0 68.5 41.8 51.4 102.5 83.5 76.3 100.2 44.0 66.7 69.0 58.5 98.8 57.0 145.2 153.0 23.7 183.7 139.4 1.6 4.8 1.3 14.7 6.2 19.7 10.3 12.1 13.9 9.2 7.4 13.4 15.9 1.2 7.3 3.4 7.8 10.2 9.8 20.3 21.9 22.6 27.3 20.0 25.2 22.0 22.0 23.3 24.1 22.2 22.8 5.7 6.4 7.5 2.9 10.8 3.1 18.6 12.2 5.7 16.9 9.0 10.5 45.8 8.6 8.3 5.5 4.2 58.7 6.6 3.3 23.5 25.7 32.0 10.3 14.2 12.3 3.6 22.7 6.5 20.3 72.3 12.2 7.7 7.7 10.8 16.3 5.0 8.2 30.1 16.8 8.6 11.4 4.1 3.3 3.6 11.7 6.8 6.4 7.2 1.9 9.2 41.0 11.3 7.5 5.4 22.1 5.5 12.4 15.0 13.5 3.3 17.1 13.5 15.5 6.6 6.1 12.8 25.7 51.0 10.6 4.5 25.3 9.2 21.1 11.9 8.6 PPIL2 "CYC4, Cyp-60, UBOX7" ENSG00000100023 "Peptidylprolyl isomerase like 2" Q13356 22 21666000-21700015 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 90.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 4 "K-562: 190.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035344, HPA055637" Supported Enhanced Nucleoplasm NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 8: Non-specific - Mitochondria" "Cluster 1: K-562 - Erythropoiesis" "Cluster 34: Spermatids - Unknown function" Nucleoplasm "HPA035344: AB_10672863, HPA055637: AB_2682869" "unprognostic (1.97e-3)" "unprognostic (3.61e-2)" "unprognostic (2.70e-2)" "unprognostic (4.31e-2)" "unprognostic (2.27e-1)" "unprognostic (2.90e-3)" "unprognostic (5.16e-3)" "unprognostic (3.77e-2)" "unprognostic (9.46e-2)" "unprognostic (1.54e-1)" "unprognostic (2.33e-2)" "unprognostic (1.89e-2)" "unprognostic (2.45e-3)" "unprognostic (5.46e-2)" "unprognostic (5.39e-2)" "unprognostic (5.39e-2)" "unprognostic (1.54e-3)" 8.9 14.2 4.7 12.8 5.7 6.3 9.5 4.0 7.0 11.6 2.1 12.1 8.1 12.0 9.3 16.4 10.7 9.5 13.9 5.8 4.8 12.6 15.0 10.1 16.4 3.5 2.9 10.7 19.2 16.4 14.3 9.1 3.9 12.4 10.6 9.0 14.7 9.5 18.8 12.3 13.3 9.9 3.6 14.0 13.9 10.1 3.1 15.8 18.8 13.0 16.4 11.7 12.1 4.8 20.4 17.1 18.1 20.1 19.2 17.6 15.8 19.3 17.9 28.0 24.5 21.3 10.3 34.0 12.7 27.2 13.9 22.9 28.6 23.6 16.2 19.2 28.2 26.7 14.2 32.4 14.7 42.5 21.5 17.4 21.2 19.4 14.0 15.1 25.1 18.5 190.3 17.9 19.6 28.6 20.5 13.7 20.2 35.7 14.9 23.7 31.1 5.7 14.2 14.1 30.8 18.4 21.2 32.7 9.7 11.3 27.1 20.3 27.5 15.8 25.1 17.5 12.7 19.2 17.5 24.7 21.6 22.6 24.9 1.5 9.7 5.1 9.6 15.3 12.2 7.2 11.5 12.6 13.7 8.3 10.5 9.4 2.3 14.1 22.6 11.9 15.6 12.1 4.7 5.7 4.0 7.0 5.8 4.8 3.5 2.9 3.9 3.6 3.1 4.8 9.8 9.6 29.5 15.0 21.5 3.2 7.9 10.9 10.8 26.3 13.4 10.2 5.7 27.1 16.6 14.7 33.3 15.8 39.4 23.9 13.7 12.8 66.8 15.4 14.8 8.0 11.4 17.7 19.9 16.7 13.3 10.3 39.3 19.5 17.1 16.6 10.4 18.9 15.3 18.5 24.2 20.6 14.2 21.0 5.3 90.9 12.2 15.5 1.8 8.4 16.6 11.5 52.5 12.5 17.4 18.5 17.4 13.5 23.8 10.9 14.2 9.1 11.9 31.4 0.0 11.2 9.4 23.6 17.3 12.3 5.7 22.2 24.5 14.8 20.8 12.6 PPIL3 CyPJ ENSG00000240344 "Peptidylprolyl isomerase like 3" Q9H2H8 2 200870907-200889303 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "mRNA processing, mRNA splicing" "Isomerase, Rotamase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040765, HPA062187" Approved Approved Nucleoplasm,Nucleoli NA NA 120000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm Nucleoli "HPA040765: AB_2677125, HPA062187: AB_2684706" "unprognostic (8.96e-3)" "unprognostic (6.07e-2)" "unprognostic (5.34e-2)" "unprognostic (8.16e-2)" "unprognostic (2.69e-2)" "unprognostic (9.61e-2)" "unprognostic (8.31e-2)" "unprognostic (8.05e-2)" "unprognostic (1.40e-2)" "prognostic favorable (1.19e-4)" "unprognostic (5.23e-2)" "unprognostic (6.60e-2)" "prognostic unfavorable (5.16e-4)" "unprognostic (1.14e-1)" "unprognostic (5.96e-2)" "unprognostic (2.21e-2)" "unprognostic (4.87e-2)" 13.0 16.4 15.2 19.8 14.9 35.1 25.4 17.0 22.3 15.7 13.9 19.0 14.6 20.2 28.4 18.6 22.5 13.0 18.2 14.6 16.8 18.4 21.9 15.0 32.2 15.7 15.5 35.4 12.1 14.0 14.9 17.7 16.8 15.1 19.5 25.8 17.1 18.2 18.0 18.0 18.1 12.4 15.4 17.5 19.0 21.1 15.5 30.1 20.8 11.1 32.5 16.2 12.5 18.2 19.9 18.3 53.0 23.5 42.5 90.8 17.5 32.0 35.3 37.1 37.2 13.0 37.5 19.5 32.0 35.4 41.9 24.6 19.3 38.1 33.2 41.4 43.8 84.0 48.3 90.6 21.3 79.7 39.8 32.7 37.7 30.3 47.1 62.0 25.3 38.4 67.4 46.3 46.3 32.4 61.7 67.2 32.9 19.8 28.9 23.3 30.5 29.1 49.6 30.4 22.2 21.1 31.3 29.9 51.7 62.3 24.6 36.9 34.2 51.4 28.8 31.2 26.2 45.5 51.0 94.2 39.6 36.2 33.7 36.2 17.5 19.7 17.5 16.4 25.5 35.2 20.9 17.7 30.9 26.7 25.3 27.6 4.5 31.8 23.1 25.6 30.3 14.6 15.2 14.9 17.0 22.3 14.6 16.8 15.7 15.5 16.8 15.4 15.5 18.2 12.5 0.0 11.5 16.0 33.6 31.7 43.1 71.5 37.5 12.0 23.7 28.2 18.5 15.7 30.4 16.5 10.4 50.3 24.8 9.7 56.7 26.0 44.1 16.1 21.4 16.2 9.5 25.5 19.3 16.1 51.6 22.1 16.3 13.4 26.0 17.2 13.6 19.4 47.0 3.3 18.1 25.3 48.8 32.1 59.1 9.5 36.7 26.8 28.4 9.4 30.2 23.1 37.0 15.1 19.7 18.2 18.1 28.2 24.5 15.9 25.4 59.7 28.7 11.9 19.7 18.2 39.6 45.7 22.6 34.5 46.3 30.8 31.1 8.9 29.4 35.6 PPIL4 ENSG00000131013 "Peptidylprolyl isomerase like 4" Q8WUA2 6 149504495-149546043 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Isomerase, RNA-binding, Rotamase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031599, HPA031600" Approved Enhanced Nucleoplasm,Cytosol NA NA "Cluster 44: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 18: U-2197 - ECM organization" "Cluster 22: Epithelial cell types - Mixed function" Nucleoplasm Cytosol "HPA031599: AB_2673950, HPA031600: AB_10600928" "unprognostic (6.12e-2)" "unprognostic (4.90e-2)" "unprognostic (3.85e-2)" "unprognostic (8.42e-2)" "unprognostic (7.53e-2)" "unprognostic (6.36e-3)" "unprognostic (2.91e-3)" "unprognostic (2.22e-1)" "unprognostic (4.22e-2)" "unprognostic (1.09e-1)" "unprognostic (2.38e-1)" "unprognostic (4.62e-2)" "unprognostic (3.88e-2)" "unprognostic (2.11e-1)" "unprognostic (1.59e-1)" "unprognostic (8.50e-2)" "unprognostic (7.94e-2)" 19.6 19.2 12.3 15.6 15.0 36.4 20.3 19.8 18.3 18.1 9.6 15.4 14.2 20.1 25.7 13.7 16.5 18.9 15.9 13.1 18.0 17.9 22.9 16.1 17.2 10.6 12.8 27.3 14.8 18.8 18.8 22.7 10.9 19.2 16.0 13.1 15.8 15.2 10.7 14.4 14.6 14.7 11.1 17.4 16.4 16.3 17.0 18.5 25.7 11.5 17.1 20.9 16.9 15.8 22.7 12.0 41.0 34.7 23.8 30.9 38.1 43.8 41.1 46.4 49.2 25.1 22.8 23.8 29.4 33.9 27.9 20.1 31.5 16.5 73.1 34.7 29.7 26.4 27.0 43.9 37.3 49.2 21.6 24.3 27.8 47.6 39.7 26.2 25.7 17.1 58.1 14.0 36.5 24.2 28.1 41.8 32.6 22.6 18.5 37.2 37.7 11.9 35.6 17.0 24.1 18.4 52.0 22.4 31.7 28.2 26.5 35.1 31.0 30.8 24.3 55.1 42.3 18.4 9.9 37.0 26.3 38.7 45.5 34.1 17.1 20.4 15.1 19.9 21.0 23.7 19.5 17.5 18.2 17.9 24.5 18.8 14.5 32.0 19.3 17.9 23.7 16.5 12.3 15.0 19.8 18.3 13.1 18.0 10.6 12.8 10.9 11.1 17.0 15.8 54.8 67.3 70.7 25.1 49.7 48.8 56.4 49.0 30.7 46.2 29.5 34.9 45.6 18.6 59.7 46.0 8.4 50.4 48.4 16.9 43.0 42.0 24.4 57.6 55.7 43.2 23.3 25.4 37.3 26.3 46.2 76.2 20.9 48.2 77.1 30.9 33.5 21.3 37.3 28.6 34.7 22.9 48.8 25.2 43.8 12.0 61.8 38.3 40.9 21.5 45.5 42.0 28.8 27.2 41.1 32.2 21.9 56.1 29.4 33.8 19.7 37.6 71.9 37.1 52.6 66.1 70.5 75.9 59.3 22.5 45.3 65.3 53.4 47.7 22.3 43.0 PPIL6 "bA425D10.6, dJ919F19.1, MGC41939, RSPH12" ENSG00000185250 "Peptidylprolyl isomerase like 6" Q8IXY8 6 109390215-109441171 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "fallopian tube: 35.6;testis: 18.9" "Cell type enhanced" "Detected in many" "Early spermatids: 374.4;Endometrial ciliated cells: 226.5;Late spermatids: 75.1;Respiratory ciliated cells: 228.6;Spermatocytes: 101.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "memory B-cell: 1.5" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "AN3-CA: 6.0;ASC diff: 9.2;ASC TERT1: 11.5;hTERT-RPE1: 8.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA036717, HPA058165" Approved Approved "Nucleoplasm,Golgi apparatus,Cytosol" NA NA "Cluster 37: B-cells - Transcription" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 49: Ciliated cells - Cilium organization" "Nucleoplasm, Cytosol" "Golgi apparatus" "HPA036717: AB_10671969, HPA058165: " "unprognostic (1.24e-1)" "unprognostic (2.40e-1)" "unprognostic (5.68e-2)" "unprognostic (2.68e-2)" "unprognostic (3.12e-1)" "unprognostic (3.61e-2)" "unprognostic (1.26e-1)" "unprognostic (5.53e-2)" "unprognostic (3.14e-1)" "unprognostic (8.03e-2)" "unprognostic (1.42e-3)" "unprognostic (2.51e-2)" "unprognostic (4.71e-2)" "unprognostic (1.95e-1)" "unprognostic (3.29e-2)" "unprognostic (5.86e-2)" "unprognostic (2.32e-1)" 1.1 0.9 4.7 0.6 5.2 0.2 3.0 5.7 5.3 3.8 12.2 1.3 1.4 3.0 9.0 1.4 35.6 1.1 2.1 4.8 5.2 4.3 0.6 4.7 0.6 7.5 8.2 5.3 2.3 5.2 2.7 1.1 5.5 1.2 1.0 7.4 2.3 2.7 4.3 1.3 0.7 2.0 7.2 0.8 1.7 18.9 5.1 0.8 11.1 1.7 0.6 1.5 1.2 7.6 1.4 1.2 1.1 6.0 9.2 11.5 0.6 0.0 2.2 0.5 0.1 0.1 1.6 0.0 0.4 0.6 0.8 0.9 1.0 0.0 0.3 0.4 0.4 0.5 0.1 0.0 4.6 0.5 0.2 2.4 5.6 0.2 3.5 8.6 0.7 1.3 0.6 0.4 0.4 0.6 0.1 0.7 0.2 4.0 0.8 0.6 0.0 0.5 4.7 0.1 1.3 2.1 0.1 0.3 3.9 0.3 0.4 0.9 0.3 0.1 0.2 1.0 0.2 0.2 0.1 0.1 1.9 0.1 0.4 0.8 0.1 0.2 0.1 0.1 0.1 1.5 0.2 0.1 0.3 0.5 0.1 0.1 0.4 0.4 0.1 0.4 0.1 0.2 4.7 5.2 5.7 5.3 4.8 5.2 7.5 8.2 5.5 7.2 5.1 7.6 2.6 6.4 6.9 11.8 1.8 2.2 3.7 18.2 2.8 2.4 5.7 7.0 3.7 2.8 22.1 3.7 2.1 0.8 0.4 0.9 25.4 1.9 374.4 226.5 7.3 1.8 3.0 0.4 15.0 1.2 0.8 3.9 2.6 5.8 0.0 4.1 1.1 0.2 0.4 1.7 6.1 2.0 22.4 0.0 0.3 75.1 5.3 1.1 3.6 3.7 0.6 7.8 0.0 8.5 6.2 0.7 0.8 5.3 0.8 3.8 1.5 13.0 228.6 13.4 0.0 5.2 5.6 101.4 21.5 1.9 3.0 0.7 1.2 3.0 2.0 1.5 PPM1A "MGC9201, PP2CA, PP2Calpha" ENSG00000100614 "Protein phosphatase, Mg2+/Mn2+ dependent 1A" P35813 14 60245752-60299087 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 142.9" "Cell type enhanced" "Detected in all" "Early spermatids: 446.2;Late spermatids: 565.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029209 Approved Supported "Plasma membrane,Cytosol" NA NA 380000 "Cluster 34: Basophils - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 51: Myeloid cells - Hemostasis" Cytosol "Plasma membrane" "HPA029209: AB_2672951" "unprognostic (3.14e-1)" "unprognostic (2.14e-1)" "unprognostic (5.64e-2)" "unprognostic (1.85e-1)" "unprognostic (4.00e-2)" "unprognostic (2.30e-2)" "unprognostic (4.50e-2)" "unprognostic (1.11e-1)" "unprognostic (3.43e-1)" "unprognostic (2.89e-2)" "unprognostic (7.96e-2)" "unprognostic (1.29e-1)" "prognostic favorable (1.57e-9)" "unprognostic (1.58e-2)" "unprognostic (1.12e-1)" "unprognostic (1.57e-2)" "unprognostic (1.37e-1)" 22.7 19.2 14.0 22.2 16.5 142.9 23.5 27.0 22.4 22.4 3.3 36.6 36.8 28.0 19.3 25.7 17.3 20.1 36.8 16.7 24.4 42.5 51.2 20.3 24.4 18.2 16.3 16.2 25.5 36.8 14.3 22.1 20.0 29.9 36.0 51.0 31.5 23.0 78.9 21.9 37.3 26.5 15.3 20.4 23.2 54.5 16.4 31.1 24.3 76.6 26.2 21.4 17.8 23.1 129.7 28.6 24.4 20.9 36.5 33.6 31.1 34.8 40.7 25.3 23.8 16.3 37.2 77.1 32.4 39.6 18.7 28.1 25.5 35.9 44.0 70.1 14.4 47.6 19.5 25.7 30.6 54.7 32.6 28.6 42.1 29.7 40.4 29.5 25.1 38.7 26.9 59.6 31.3 56.5 71.5 12.8 23.0 25.8 23.9 25.3 56.5 25.0 30.4 61.2 41.2 31.0 36.1 41.7 30.1 22.2 42.0 23.5 35.1 52.4 52.0 23.3 25.0 46.1 28.1 89.9 24.0 21.2 27.1 5.4 1.0 3.0 1.8 1.0 1.9 0.9 1.4 1.6 1.5 3.0 1.1 1.0 4.4 2.9 1.2 0.9 2.6 0.9 14.0 16.5 27.0 22.4 16.7 24.4 18.2 16.3 20.0 15.3 16.4 23.1 25.9 16.0 22.6 43.8 34.2 77.4 41.3 17.6 34.7 42.2 41.6 22.7 95.0 44.3 20.0 38.6 64.6 31.9 49.1 111.2 33.2 24.6 446.2 31.3 34.6 31.5 60.9 93.5 77.8 24.4 24.0 36.6 25.5 38.8 26.6 20.7 22.9 73.3 28.2 58.9 71.6 60.2 22.4 33.5 51.0 565.6 42.3 58.6 60.5 25.3 26.8 40.1 45.3 66.4 53.4 34.6 87.8 52.3 45.4 86.5 128.5 90.0 17.8 66.8 39.5 36.2 35.9 69.8 25.3 32.9 82.3 73.5 40.8 19.4 42.1 69.6 PPM1B "PP2CB, PP2CBETA, PPC2BETAX" ENSG00000138032 "Protein phosphatase, Mg2+/Mn2+ dependent 1B" O75688 2 44167969-44244384 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 218.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" HPA016745 Approved Approved Nucleoli,Cytosol NA NA 75000 "Cluster 52: Eosinophils - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 46: Photoreceptor cells - Phototransduction" "Nucleoli, Cytosol" "HPA016745: AB_1855622" "unprognostic (5.49e-2)" "unprognostic (2.67e-2)" "unprognostic (1.11e-2)" "unprognostic (2.96e-3)" "unprognostic (1.92e-2)" "unprognostic (1.48e-1)" "unprognostic (1.04e-1)" "unprognostic (1.50e-2)" "unprognostic (1.58e-1)" "unprognostic (1.94e-1)" "unprognostic (2.25e-1)" "unprognostic (6.71e-2)" "unprognostic (1.70e-2)" "unprognostic (3.81e-2)" "unprognostic (1.06e-1)" "unprognostic (1.34e-1)" "unprognostic (1.75e-2)" 40.2 20.4 41.2 19.5 48.0 44.0 23.9 45.1 61.8 23.0 43.1 28.6 20.3 23.9 30.0 22.5 21.2 21.8 33.3 38.6 42.1 29.0 44.0 21.9 28.7 41.4 44.1 22.9 32.4 35.8 18.9 18.8 42.1 30.6 28.7 49.9 27.0 23.3 129.4 20.5 21.7 22.8 40.2 26.4 23.1 21.4 42.7 36.0 22.8 86.5 27.0 24.7 21.4 50.9 37.1 32.8 41.8 31.2 51.3 23.8 47.6 27.9 32.0 28.2 24.8 43.8 23.3 40.7 42.4 32.4 23.0 19.6 47.6 18.2 41.6 41.7 18.4 42.9 19.9 30.8 41.4 38.6 34.1 23.0 31.5 22.5 37.9 22.2 23.5 18.4 31.7 41.5 25.7 30.6 38.6 61.5 52.4 33.4 11.0 40.5 46.6 27.1 66.3 36.9 33.7 42.5 25.3 37.4 33.5 62.3 20.2 26.7 21.6 24.7 35.5 20.6 27.8 36.2 25.5 37.7 13.4 63.2 18.3 6.9 2.2 8.1 4.6 3.0 3.9 4.2 4.3 3.9 3.7 4.5 5.8 4.0 6.1 3.2 3.6 3.6 4.3 1.1 41.2 48.0 45.1 61.8 38.6 42.1 41.4 44.1 42.1 40.2 42.7 50.9 17.4 19.2 20.8 78.4 49.3 60.5 40.3 14.4 35.3 51.9 31.8 19.9 55.4 38.6 24.0 40.5 64.6 31.5 68.6 64.5 46.9 42.5 68.5 44.1 33.3 22.0 40.2 32.8 95.9 46.4 29.7 33.7 35.2 62.4 26.6 27.4 20.3 55.0 26.8 107.7 91.8 31.5 30.5 55.2 63.0 43.0 35.8 45.0 56.9 38.4 46.7 57.5 51.5 112.6 218.0 44.7 46.6 33.8 51.9 71.2 26.8 41.0 16.9 147.5 26.3 33.5 32.4 48.5 27.7 36.6 62.4 64.6 63.8 29.5 37.3 88.7 PPM1D "PP2C-DELTA, Wip1" ENSG00000170836 "Protein phosphatase, Mg2+/Mn2+ dependent 1D" O15297 17 60600183-60666280 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle" "Hydrolase, Protein phosphatase" "Autism spectrum disorder, Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 68.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MCF7: 34.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022277, HPA061848" Approved Supported Nucleoplasm,Nucleoli NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 59: Non-specific - Transcription" Nucleoplasm Nucleoli "HPA022277: AB_1858839, HPA061848: " "unprognostic (1.48e-1)" "unprognostic (1.36e-2)" "prognostic favorable (3.52e-4)" "unprognostic (1.76e-1)" "unprognostic (1.02e-1)" "unprognostic (5.12e-2)" "prognostic unfavorable (4.27e-4)" "unprognostic (5.50e-2)" "unprognostic (1.70e-2)" "unprognostic (6.07e-2)" "unprognostic (2.52e-3)" "unprognostic (3.46e-2)" "unprognostic (1.95e-3)" "unprognostic (7.33e-2)" "unprognostic (1.58e-1)" "unprognostic (1.71e-2)" "unprognostic (1.98e-1)" 4.4 2.4 2.7 2.2 5.2 5.9 3.9 14.8 4.6 4.5 5.0 3.1 2.9 4.3 2.9 3.5 3.7 3.1 2.9 3.3 3.4 2.8 2.8 3.6 2.7 4.0 3.5 6.3 3.3 2.3 2.4 5.9 4.7 3.1 3.5 6.4 3.1 2.2 4.0 2.9 2.7 3.0 3.4 3.8 2.7 5.5 3.7 4.4 2.9 3.1 2.3 2.8 4.0 9.1 3.8 6.9 7.5 6.4 5.0 3.1 10.7 5.8 3.6 3.4 4.9 7.1 2.0 9.9 4.5 3.7 1.3 3.4 4.9 2.2 4.6 1.9 11.1 7.4 6.7 8.1 4.2 2.9 5.3 2.7 3.6 5.1 3.0 2.8 7.9 4.1 5.4 4.0 3.7 34.4 8.1 4.4 3.5 3.4 5.2 9.5 9.6 6.6 3.1 4.2 10.5 7.4 7.1 2.4 1.6 8.0 2.8 3.9 5.7 4.7 12.5 3.5 3.3 6.7 7.7 7.3 1.7 2.9 3.8 9.9 16.1 18.0 7.6 12.5 6.8 8.9 6.3 7.0 16.0 6.2 6.8 7.0 24.7 8.6 8.1 7.0 10.6 9.8 2.7 5.2 14.8 4.6 3.3 3.4 4.0 3.5 4.7 3.4 3.7 9.1 40.9 32.1 7.7 15.0 23.1 21.0 6.2 3.3 52.3 13.1 14.2 9.8 6.3 8.6 4.6 5.5 4.2 17.6 19.4 15.0 3.9 6.6 68.9 14.0 15.5 25.2 14.4 14.1 19.6 6.6 6.4 14.7 10.2 15.6 1.3 7.2 23.6 4.2 8.8 3.3 20.8 11.4 6.1 21.4 19.2 12.8 13.7 16.1 3.6 28.1 12.3 7.0 6.2 20.6 38.6 5.4 10.2 7.5 24.5 7.8 8.7 5.1 3.6 10.4 0.0 12.1 14.0 43.8 15.0 34.4 18.0 38.6 18.1 6.0 11.5 7.7 PPM1E "CaMKP-N, KIAA1072, POPX1, PP2CH" ENSG00000175175 "Protein phosphatase, Mg2+/Mn2+ dependent 1E" Q8WY54 17 58755854-58985179 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 39.2;retina: 22.3" "Group enriched" "Detected in some" 4 "Excitatory neurons: 220.9;Horizontal cells: 77.4;Inhibitory neurons: 288.4;Oligodendrocyte precursor cells: 109.1" "Cancer enhanced" "Detected in some" "glioma: 2.7;prostate cancer: 3.0" "Group enriched" "Detected in many" 4 "cerebral cortex: 31.6;hippocampal formation: 39.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 12.2;HAP1: 19.9;MOLT-4: 9.9;SCLC-21H: 9.1;SH-SY5Y: 18.7;THP-1: 8.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018462, HPA019263" Approved Approved Nucleoplasm,Nucleoli Yes No "Cluster 46: Basophils - DNA binding" "Cluster 58: Brain - Synaptic function" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoli Nucleoplasm "HPA018462: AB_1855623, HPA019263: AB_1855624" "unprognostic (2.50e-2)" "unprognostic (5.75e-2)" "unprognostic (8.12e-2)" "unprognostic (2.99e-2)" "unprognostic (5.30e-1)" "unprognostic (8.19e-2)" "unprognostic (3.96e-1)" "unprognostic (1.52e-1)" "unprognostic (3.22e-2)" "unprognostic (5.24e-2)" "unprognostic (8.80e-5)" "unprognostic (4.97e-2)" "unprognostic (1.23e-7)" "unprognostic (1.05e-4)" "unprognostic (1.64e-2)" "unprognostic (1.27e-1)" "unprognostic (9.12e-2)" 0.1 5.5 5.3 0.1 4.8 0.0 0.1 1.0 31.6 0.2 0.0 0.1 0.1 0.3 0.9 0.0 1.5 0.1 1.0 39.2 7.3 0.7 1.0 0.2 0.2 1.9 4.2 0.2 0.6 0.3 1.3 0.0 3.2 1.4 0.0 22.3 0.2 0.0 0.0 0.0 0.2 0.3 0.3 0.2 0.5 6.7 8.0 0.2 0.1 0.1 0.2 0.1 0.1 2.3 0.0 0.1 12.2 0.6 0.0 0.0 0.9 0.0 0.0 0.9 1.4 0.0 0.0 8.0 0.1 0.1 2.7 0.0 19.9 0.0 0.5 0.2 5.9 0.0 0.2 0.0 1.3 0.6 2.6 0.3 1.6 0.1 0.0 0.6 0.0 4.9 2.1 0.0 0.0 3.6 9.9 0.0 3.5 0.0 1.0 0.0 1.5 0.0 0.0 0.0 9.1 18.7 0.3 0.0 1.3 0.1 0.0 8.7 0.0 0.0 2.2 0.0 2.9 0.1 0.1 5.4 0.3 0.0 2.9 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.3 4.8 1.0 31.6 39.2 7.3 1.9 4.2 3.2 0.3 8.0 2.3 0.1 0.0 0.0 32.7 0.0 0.0 0.0 0.0 0.0 22.0 0.1 0.4 3.3 0.0 1.8 0.0 31.3 0.0 0.0 0.1 0.0 0.0 30.8 3.9 0.1 0.3 3.0 0.0 220.9 0.0 0.0 0.4 0.0 0.1 0.0 0.1 0.0 1.4 0.1 77.4 288.4 0.0 0.0 0.3 0.0 17.6 0.0 0.1 0.0 5.6 0.0 4.2 0.0 109.1 38.4 0.0 0.2 0.4 0.0 1.3 0.0 0.1 0.0 13.8 0.0 0.0 0.5 12.1 2.8 0.0 0.0 0.0 0.0 0.8 0.0 0.0 PPM1F "CAMKP, CaMKPase, FEM-2, KIAA0015, POPX2" ENSG00000100034 "Protein phosphatase, Mg2+/Mn2+ dependent 1F" P49593 22 21919425-21952848 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Apoptosis "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Endothelial cells: 42.2;Hepatic stellate cells: 56.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 28.6" "Group enriched" "Detected in all" 7 "dendritic cells: 8.9;granulocytes: 28.6;monocytes: 24.4" "Cell line enhanced" "Detected in all" "HUVEC TERT2: 109.1;K-562: 173.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030989, HPA030990" Approved Approved "Nucleoplasm,Plasma membrane" NA NA 510000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 1: K-562 - Erythropoiesis" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Nucleoplasm "Plasma membrane" "HPA030989: AB_10669549, HPA030990: AB_10601249" "unprognostic (6.26e-2)" "unprognostic (2.50e-1)" "unprognostic (1.82e-1)" "unprognostic (2.11e-1)" "unprognostic (2.51e-1)" "unprognostic (4.77e-3)" "unprognostic (4.88e-3)" "unprognostic (1.94e-1)" "unprognostic (1.70e-1)" "unprognostic (1.65e-2)" "unprognostic (1.45e-2)" "unprognostic (4.81e-2)" "prognostic unfavorable (6.03e-5)" "unprognostic (6.44e-2)" "unprognostic (3.02e-2)" "unprognostic (3.30e-1)" "unprognostic (4.11e-2)" 24.1 18.1 14.9 21.6 13.9 26.8 17.6 11.6 15.7 18.5 11.8 17.1 8.9 19.9 3.8 22.1 15.0 12.2 16.8 14.5 19.4 18.4 8.0 26.1 15.2 16.8 16.4 12.5 12.3 6.4 8.5 26.6 17.3 15.8 4.2 3.7 10.9 14.3 17.0 14.8 13.8 12.1 15.3 35.8 12.0 6.3 17.1 7.8 12.4 10.5 7.8 22.0 15.9 15.4 28.9 30.1 19.0 18.6 10.4 18.1 23.9 32.1 18.9 27.7 19.0 13.8 11.3 17.3 39.0 22.7 11.8 33.9 8.3 19.9 9.8 24.7 27.1 66.8 14.5 13.2 17.1 25.0 17.4 17.1 5.9 27.1 12.6 19.6 109.1 16.9 173.4 7.2 35.9 26.2 15.0 19.3 8.0 9.2 32.7 21.9 49.0 5.2 9.4 12.1 7.7 29.6 30.4 10.0 25.7 7.4 12.5 17.2 93.1 33.1 33.4 30.5 31.1 14.1 12.2 19.6 33.5 46.7 64.7 0.0 12.8 5.9 1.7 21.0 1.0 1.1 1.1 0.9 8.9 0.9 1.0 1.3 28.6 3.1 24.4 2.2 2.4 5.4 14.9 13.9 11.6 15.7 14.5 19.4 16.8 16.4 17.3 15.3 17.1 15.4 32.1 6.4 6.0 11.8 5.5 8.2 5.2 4.9 8.6 8.3 7.4 9.9 11.9 8.6 4.1 1.8 2.1 16.6 5.1 1.4 3.9 5.2 2.0 3.0 9.4 42.2 6.0 5.5 11.6 5.1 10.0 8.4 3.1 3.8 3.8 10.4 56.4 6.5 20.6 8.4 12.7 4.2 6.1 37.0 22.0 1.5 7.2 23.4 7.2 18.7 30.9 4.1 6.2 12.5 6.8 7.4 1.1 6.8 5.0 7.4 2.6 4.4 4.0 6.5 6.6 17.2 8.2 14.2 13.1 8.5 5.7 3.0 6.4 7.1 4.5 6.6 PPM1G "PP2CG, PP2Cgamma" ENSG00000115241 "Protein phosphatase, Mg2+/Mn2+ dependent 1G" O15355 2 27381195-27409591 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 233.9" "Cell type enhanced" "Detected in all" "Early spermatids: 1540.4;Late spermatids: 3492.8;Spermatocytes: 793.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035530, HPA035531" Enhanced Enhanced Nucleoplasm NA NA 19000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 31: Spermatids - Spermatogenesis" Nucleoplasm "HPA035530: AB_10670021, HPA035531: AB_10610283" "unprognostic (7.50e-2)" "unprognostic (8.89e-2)" "unprognostic (1.53e-1)" "unprognostic (1.02e-1)" "unprognostic (2.27e-1)" "unprognostic (4.15e-2)" "prognostic unfavorable (3.14e-7)" "unprognostic (9.36e-3)" "unprognostic (7.73e-2)" "prognostic favorable (6.08e-5)" "unprognostic (3.74e-2)" "unprognostic (1.23e-1)" "unprognostic (7.46e-3)" "unprognostic (1.06e-2)" "unprognostic (5.33e-2)" "unprognostic (1.78e-1)" "unprognostic (7.83e-2)" 46.0 49.6 34.7 45.1 35.1 73.5 43.6 35.4 37.8 38.4 36.9 48.3 39.9 45.6 26.1 62.6 39.0 28.0 44.9 35.0 37.0 40.7 45.3 40.6 59.6 35.4 36.0 34.9 53.0 41.4 43.4 37.6 35.3 36.0 51.3 20.0 45.1 38.8 95.7 41.2 43.0 44.9 35.1 47.1 47.8 233.9 36.0 64.9 36.8 53.0 75.3 47.0 39.6 35.3 302.0 243.1 174.0 134.8 108.7 88.0 160.6 182.8 119.8 214.8 170.9 377.7 154.4 352.7 130.9 130.9 181.8 160.3 296.4 205.6 191.4 148.4 241.1 343.6 172.9 404.0 97.9 343.5 139.2 95.7 116.9 219.2 175.1 101.7 209.1 171.1 293.3 106.0 165.5 269.4 256.7 370.5 254.1 207.1 173.1 261.1 365.0 185.3 145.9 206.4 233.2 264.0 164.4 178.9 135.9 137.4 99.4 111.3 169.5 159.3 192.6 141.6 281.8 229.0 277.0 545.5 124.8 275.6 122.5 67.3 41.5 59.0 57.5 52.3 56.8 44.7 61.1 60.3 65.4 37.9 45.1 47.4 20.9 55.0 71.4 91.9 88.9 48.0 34.7 35.1 35.4 37.8 35.0 37.0 35.4 36.0 35.3 35.1 36.0 35.3 72.9 64.1 51.3 9.8 76.7 81.1 88.7 71.9 83.6 40.8 63.1 59.3 37.9 52.9 63.7 69.9 29.2 93.9 114.2 81.0 33.2 135.7 1540.4 102.7 75.8 80.8 80.7 119.6 19.5 139.3 163.8 56.6 69.3 89.8 59.1 76.1 40.4 44.7 85.4 48.8 21.1 78.9 54.9 59.7 75.7 3492.8 70.2 68.2 24.9 17.8 127.3 69.7 112.3 17.1 15.9 156.7 52.7 71.1 137.8 152.1 52.6 61.4 61.8 41.7 46.0 54.9 80.5 793.3 298.9 108.7 80.6 53.1 89.7 123.7 106.4 122.6 PPM1K "BDP, DKFZp761G058, hPTMP, PP2Ckappa, PP2Cm" ENSG00000163644 "Protein phosphatase, Mg2+/Mn2+ dependent 1K" Q8N3J5 4 88257620-88284769 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 92.5" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 512.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Daudi: 58.0;Karpas-707: 48.6;U-698: 48.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020066, HPA020862, HPA023891" Approved Supported Mitochondria No No "Cluster 24: B-cells - Unknown function" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 54: Cardiomyocytes - Muscle contraction" Mitochondria "HPA020066: AB_1855628, HPA020862: AB_1855629, HPA023891: AB_1855630" "unprognostic (2.38e-2)" "unprognostic (5.86e-2)" "unprognostic (7.42e-3)" "unprognostic (6.70e-3)" "unprognostic (1.18e-1)" "unprognostic (1.17e-3)" "unprognostic (1.87e-1)" "unprognostic (5.88e-2)" "unprognostic (5.50e-2)" "unprognostic (1.41e-2)" "unprognostic (9.25e-3)" "unprognostic (6.56e-2)" "unprognostic (9.82e-2)" "unprognostic (5.57e-2)" "unprognostic (1.34e-1)" "unprognostic (2.11e-1)" "unprognostic (2.28e-1)" 5.3 8.5 23.3 14.9 26.3 9.9 14.5 22.5 31.2 19.4 22.0 5.9 4.4 32.7 7.6 11.2 21.5 8.9 92.5 26.5 23.9 17.8 7.6 9.7 25.6 19.9 22.3 32.5 11.1 12.5 9.9 9.7 22.9 16.2 6.0 14.2 11.8 7.1 14.2 2.6 10.4 26.6 22.1 18.9 8.0 19.9 27.7 15.2 7.9 11.5 25.8 8.9 11.7 33.2 4.6 1.5 5.7 10.1 8.3 10.9 2.3 7.2 13.0 23.3 27.4 11.6 1.1 58.0 7.7 4.6 11.5 0.5 17.0 5.4 9.1 44.9 7.1 10.8 5.0 10.8 6.6 14.6 5.3 7.2 2.7 14.5 12.5 4.9 4.2 25.4 15.5 48.6 7.0 6.5 20.3 7.9 3.4 3.5 2.3 10.8 9.3 21.9 8.1 2.0 4.4 3.9 4.6 0.5 5.4 9.6 23.2 3.9 0.8 8.3 4.2 2.8 4.1 15.6 15.0 48.3 9.1 11.7 14.0 24.7 9.9 8.1 39.4 12.0 51.4 102.9 37.1 39.9 18.6 113.5 36.3 44.2 3.2 27.6 3.6 131.3 46.9 24.5 23.3 26.3 22.5 31.2 26.5 23.9 19.9 22.3 22.9 22.1 27.7 33.2 20.7 48.1 12.4 105.4 124.8 9.8 15.8 5.7 29.6 109.5 42.8 25.7 512.1 8.6 13.7 49.7 18.8 11.5 153.0 0.8 156.5 7.0 7.9 9.7 37.2 27.2 9.6 34.3 89.5 6.2 3.2 42.9 8.2 20.0 19.0 32.2 24.7 30.2 28.9 85.8 145.6 16.5 4.1 14.5 16.4 10.5 23.9 27.5 21.4 40.3 75.6 21.8 80.3 100.0 54.7 4.6 9.2 31.6 82.7 32.1 8.2 47.6 19.5 14.8 26.3 38.5 36.4 38.2 22.9 71.4 5.4 2.9 70.1 45.4 4.1 6.7 PPM1M "FLJ32332, PP2Ceta" ENSG00000164088 "Protein phosphatase, Mg2+/Mn2+ dependent 1M" Q96MI6 3 52245759-52250599 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hofbauer cells: 42.2;Kupffer cells: 39.0;Macrophages: 31.1;NK-cells: 30.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "U-266/70: 54.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036905, HPA062291" Uncertain Approved "Nuclear bodies" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 63: NK-cells & T-cells - Immune response" "Nuclear bodies" "HPA036905: AB_10602818, HPA062291: AB_2684740" "unprognostic (4.26e-3)" "prognostic favorable (7.73e-4)" "unprognostic (2.55e-2)" "unprognostic (4.85e-3)" "unprognostic (5.64e-2)" "unprognostic (4.88e-3)" "unprognostic (1.70e-2)" "prognostic favorable (6.69e-4)" "unprognostic (4.63e-2)" "unprognostic (1.69e-1)" "unprognostic (1.50e-1)" "unprognostic (1.19e-1)" "prognostic unfavorable (1.61e-5)" "unprognostic (1.49e-1)" "unprognostic (4.14e-2)" "unprognostic (9.27e-2)" "unprognostic (4.37e-2)" 19.5 9.4 12.7 20.3 13.7 24.6 15.5 9.9 13.6 25.9 12.2 18.7 6.0 18.3 9.9 12.3 18.1 14.1 11.4 13.6 14.2 10.9 5.6 23.5 29.6 12.8 11.4 18.6 8.0 11.2 9.1 11.6 12.2 16.7 8.7 2.2 11.6 15.2 3.7 10.7 13.1 18.0 12.0 30.1 11.4 8.8 15.5 27.6 13.8 7.8 28.2 17.5 18.2 12.9 0.9 5.4 3.2 7.6 46.1 45.7 5.2 12.2 26.2 17.0 13.1 3.2 4.2 9.0 3.6 32.0 9.5 1.5 10.9 2.3 6.9 11.0 2.7 20.5 14.6 3.3 33.6 3.1 18.7 37.8 5.2 18.9 11.9 27.3 22.2 40.5 3.6 14.5 20.2 2.2 13.7 0.9 4.1 4.0 14.7 3.0 1.6 20.0 7.3 2.6 2.3 9.3 9.0 2.2 11.1 6.8 7.6 7.9 15.5 6.5 10.7 3.8 1.6 54.3 11.2 9.9 12.7 5.4 8.0 1.8 24.1 13.3 20.6 19.3 15.9 6.8 16.1 19.2 14.4 7.4 15.2 19.0 28.9 11.7 29.6 8.5 20.5 17.5 12.7 13.7 9.9 13.6 13.6 14.2 12.8 11.4 12.2 12.0 15.5 12.9 6.8 0.0 5.4 1.3 15.4 5.1 6.5 0.7 8.0 1.6 5.9 7.2 1.8 5.7 2.0 1.8 0.0 3.3 25.9 0.7 3.9 1.8 9.7 4.7 8.9 7.0 1.2 3.0 1.5 1.1 5.8 11.9 3.1 11.0 5.7 7.3 12.5 3.7 42.2 1.7 0.6 0.4 2.0 39.0 17.0 18.0 12.8 31.1 5.4 4.7 29.1 5.1 30.9 1.5 0.7 1.3 3.2 9.8 11.4 2.3 0.9 3.0 0.9 0.7 19.7 5.2 7.3 0.7 4.2 11.9 3.8 1.9 25.1 3.1 1.0 3.5 PPP1CA "PP-1A, PP1A, PP1alpha, PPP1A" ENSG00000172531 "Protein phosphatase 1 catalytic subunit alpha" P62136 11 67398181-67421183 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Cell cycle, Cell division, Glycogen metabolism, Host-virus interaction" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004545, HPA046833" Enhanced Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA 3600000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 52: Non-specific - Ribosome" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Plasma membrane, Cytosol" "CAB004545: AB_628177, HPA046833: AB_2679829" "unprognostic (1.03e-1)" "unprognostic (5.82e-3)" "unprognostic (1.10e-1)" "unprognostic (2.67e-1)" "unprognostic (2.09e-1)" "unprognostic (1.51e-2)" "unprognostic (3.15e-3)" "unprognostic (3.93e-2)" "unprognostic (2.07e-1)" "unprognostic (3.89e-2)" "unprognostic (5.05e-3)" "unprognostic (8.00e-2)" "unprognostic (1.66e-1)" "unprognostic (9.96e-2)" "unprognostic (7.69e-2)" "prognostic favorable (1.17e-4)" "unprognostic (7.60e-2)" 70.0 102.4 61.2 102.6 70.8 127.8 63.5 64.0 70.7 62.1 61.2 110.8 95.9 50.5 66.8 184.0 61.1 51.2 122.0 63.5 63.6 121.8 128.2 78.9 147.8 68.3 62.4 33.1 105.1 64.2 59.8 83.5 63.8 81.1 89.6 21.6 100.4 51.0 123.2 105.8 107.1 56.1 63.9 148.7 102.7 34.6 65.8 113.7 88.7 81.3 155.6 74.9 80.6 68.2 283.1 305.6 181.1 270.3 88.4 108.9 185.6 136.1 158.4 267.4 202.3 445.8 328.5 237.2 227.3 208.1 198.4 238.7 213.9 280.2 169.6 256.3 139.9 227.5 129.3 232.7 195.2 295.2 281.1 123.3 181.1 225.7 130.7 125.4 272.2 226.0 217.4 191.1 220.5 619.4 378.2 562.2 303.5 526.7 241.1 262.7 254.0 209.8 262.2 220.7 142.5 236.7 159.2 283.0 439.8 135.3 338.5 201.2 196.4 208.5 208.9 245.3 179.0 190.1 193.2 271.8 244.6 199.9 224.3 921.6 735.9 1234.1 779.2 962.9 604.3 733.4 679.9 792.5 705.3 779.6 412.6 584.2 853.8 688.8 1186.1 500.4 1098.7 2042.5 61.2 70.8 64.0 70.7 63.5 63.6 68.3 62.4 63.8 63.9 65.8 68.2 49.2 76.9 92.2 8.8 165.8 99.9 143.5 305.9 64.3 35.5 81.7 79.1 8.4 102.9 157.8 86.5 10.4 360.4 151.2 377.5 213.2 265.6 2.5 63.1 67.2 101.6 96.9 108.8 8.8 311.1 507.0 68.8 132.0 107.1 109.6 87.1 89.3 113.9 377.1 43.7 7.7 241.3 181.0 219.8 138.5 7.7 49.0 186.5 136.9 9.4 353.0 53.8 408.8 6.0 13.1 318.4 308.4 28.6 206.5 139.0 341.3 297.4 70.5 30.5 98.6 67.1 100.7 13.6 94.6 142.0 121.6 427.3 176.3 100.1 231.7 205.4 PPP1CB "MP, PP-1B, PP1B, PP1beta, PP1c, PPP1beta" ENSG00000213639 "Protein phosphatase 1 catalytic subunit beta" P62140 2 28751640-28802940 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, Carbohydrate metabolism, Cell cycle, Cell division, Glycogen metabolism" "Hydrolase, Protein phosphatase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Langerhans cells: 985.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022558, HPA065425, CAB069426" Supported Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA 3800000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 24: Non-specific - Transcription regulation" "Nucleoplasm, Cytosol" "Plasma membrane" "CAB022558: , CAB069426: , HPA065425: AB_2685489" "unprognostic (2.90e-1)" "unprognostic (5.03e-2)" "unprognostic (5.49e-2)" "unprognostic (2.00e-1)" "unprognostic (7.08e-2)" "unprognostic (1.39e-1)" "prognostic unfavorable (6.52e-6)" "unprognostic (3.47e-2)" "unprognostic (2.44e-1)" "unprognostic (3.15e-2)" "unprognostic (1.54e-3)" "unprognostic (3.95e-1)" "unprognostic (1.68e-1)" "unprognostic (3.66e-1)" "unprognostic (1.89e-1)" "unprognostic (4.56e-1)" "unprognostic (2.26e-2)" 90.9 75.2 55.8 74.7 73.5 119.1 110.5 55.6 74.9 148.6 67.8 109.2 84.8 138.4 104.0 245.7 113.5 103.1 185.2 54.3 73.8 84.4 70.5 73.3 60.4 73.9 61.2 92.7 76.2 126.9 45.9 74.8 74.5 149.1 92.9 70.8 114.6 123.4 386.0 73.7 76.0 159.7 71.8 65.8 81.7 47.6 63.5 71.3 78.8 262.8 91.1 118.0 104.1 88.2 186.0 114.6 391.1 121.7 130.8 121.0 227.0 97.7 110.6 92.2 91.0 102.6 106.9 147.5 119.2 101.5 102.7 111.4 112.6 129.9 109.8 235.9 58.2 111.3 130.1 111.5 284.3 127.8 50.5 93.5 181.3 100.1 207.8 97.4 113.8 77.0 103.6 140.4 123.3 93.2 136.9 110.3 128.3 141.8 89.8 132.2 344.9 112.7 304.3 220.6 106.7 131.3 151.4 166.2 136.2 111.4 80.4 70.6 137.6 122.6 134.6 89.3 119.0 100.4 171.0 299.8 130.1 135.0 93.5 72.4 59.4 84.9 39.8 96.7 50.8 38.6 59.3 46.8 65.4 31.6 51.8 58.8 103.6 61.4 115.2 49.8 74.3 52.8 55.8 73.5 55.6 74.9 54.3 73.8 73.9 61.2 74.5 71.8 63.5 88.2 172.2 93.0 80.6 59.4 147.8 492.1 176.7 101.5 64.9 62.4 208.0 117.0 352.1 112.9 124.1 310.8 27.1 129.6 210.4 324.5 244.6 297.0 514.0 330.2 245.7 129.3 283.0 200.2 68.5 210.5 202.1 147.8 78.5 258.9 146.6 91.2 137.8 108.7 114.7 163.2 71.8 144.2 111.9 182.6 985.1 406.2 196.7 238.1 336.2 59.0 137.9 116.6 55.6 64.3 68.4 236.8 181.3 302.0 100.9 364.9 106.6 227.4 213.3 65.2 631.1 225.8 264.8 55.2 66.6 135.6 458.0 392.9 237.7 65.8 154.4 498.9 PPP1CC "PP1C, PP1gamma" ENSG00000186298 "Protein phosphatase 1 catalytic subunit gamma" P36873 12 110719680-110742939 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Biological rhythms, Carbohydrate metabolism, Cell cycle, Cell division, Glycogen metabolism" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 639.3;Late spermatids: 923.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB022645 Uncertain NA NA 2800000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 9: Intestine - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 31: Spermatids - Spermatogenesis" "CAB022645: " "unprognostic (1.51e-1)" "prognostic favorable (7.44e-4)" "unprognostic (4.00e-2)" "unprognostic (2.11e-1)" "unprognostic (1.29e-2)" "unprognostic (7.26e-2)" "prognostic unfavorable (2.75e-6)" "unprognostic (6.55e-2)" "unprognostic (4.11e-2)" "unprognostic (6.91e-2)" "unprognostic (4.96e-3)" "unprognostic (5.72e-2)" "unprognostic (2.92e-3)" "unprognostic (1.66e-2)" "unprognostic (1.71e-1)" "unprognostic (8.96e-2)" "unprognostic (1.18e-1)" 63.3 64.9 58.8 76.8 61.7 103.6 72.5 67.1 69.7 59.4 53.2 110.5 193.2 66.7 57.5 92.0 59.2 57.2 91.5 56.1 66.5 60.4 64.4 53.6 139.0 60.0 62.7 90.3 74.0 68.4 41.5 53.2 60.5 58.5 108.4 125.0 71.6 55.2 157.7 60.7 147.7 76.8 59.8 73.4 73.5 142.3 62.7 107.7 54.9 175.8 131.4 86.3 53.6 65.7 221.0 130.2 217.5 160.0 128.9 176.6 166.0 124.1 183.1 201.0 159.6 223.8 109.0 341.7 91.2 133.8 125.8 122.5 295.3 162.7 278.9 200.2 198.9 221.7 93.0 230.4 105.1 285.5 184.4 112.4 130.5 152.8 135.2 213.2 236.4 190.3 225.1 90.0 186.6 91.7 232.8 318.3 343.6 144.0 190.8 224.9 150.2 216.9 129.6 164.2 174.7 140.3 137.2 162.4 246.7 190.5 254.6 219.9 106.1 102.2 168.8 139.1 158.0 140.4 157.4 291.2 96.2 203.8 159.2 38.3 33.3 54.7 13.2 26.3 12.8 31.7 23.8 18.8 32.8 27.4 19.8 16.4 27.8 14.9 35.0 12.8 25.4 24.3 58.8 61.7 67.1 69.7 56.1 66.5 60.0 62.7 60.5 59.8 62.7 65.7 71.3 35.3 32.2 27.7 163.4 209.2 124.0 89.6 150.8 203.2 77.6 63.6 138.5 78.6 52.4 36.8 68.8 136.5 61.3 103.9 93.9 75.7 639.3 43.9 72.1 88.8 85.0 131.3 17.9 125.9 204.6 129.6 74.5 47.9 58.4 87.8 62.2 43.4 132.7 102.6 29.9 109.8 93.6 161.3 111.8 923.3 89.8 88.9 128.1 30.0 96.0 91.8 57.7 34.7 34.3 88.3 144.0 138.8 234.3 159.7 305.2 94.6 28.9 110.5 111.7 75.9 133.8 314.6 51.7 161.1 210.0 132.2 106.5 121.8 164.8 156.3 PPP1R1A ENSG00000135447 "Protein phosphatase 1 regulatory inhibitor subunit 1A" Q13522 12 54575387-54588659 "Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Glycogen metabolism" "Protein phosphatase inhibitor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 259.7;skeletal muscle: 831.6;tongue: 271.1" "Cell type enriched" "Detected in many" 4 "Distal tubular cells: 1348.0" "Cancer enhanced" "Detected in many" "liver cancer: 17.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "ASC diff: 8.8;NTERA-2: 29.4;RPTEC TERT1: 32.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007811, HPA041542" Approved NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 39: Non-specific - Basic cellular processes" "CAB007811: AB_598171, HPA041542: AB_2677542" "unprognostic (6.39e-3)" "unprognostic (2.61e-1)" "unprognostic (4.61e-3)" "prognostic unfavorable (2.36e-5)" "unprognostic (1.55e-1)" "unprognostic (1.85e-1)" "unprognostic (8.19e-3)" "unprognostic (1.01e-1)" "unprognostic (1.09e-1)" "unprognostic (7.04e-2)" "unprognostic (2.71e-3)" "unprognostic (1.76e-3)" "unprognostic (2.88e-3)" "unprognostic (7.68e-3)" "unprognostic (2.17e-1)" "unprognostic (8.49e-3)" "unprognostic (7.49e-2)" 241.3 2.6 37.1 1.1 73.6 0.3 169.8 26.1 45.7 1.6 20.4 29.6 3.0 2.2 0.7 10.3 3.8 1.5 110.9 38.9 36.9 259.7 138.1 1.0 0.5 29.0 32.0 7.7 14.2 20.8 1.8 0.0 26.0 7.9 1.8 14.6 9.7 3.2 831.6 7.6 13.2 3.3 25.5 0.5 27.8 2.2 31.6 0.2 2.6 271.1 0.5 5.4 1.5 34.1 0.0 0.0 3.9 0.0 8.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 5.4 0.0 0.0 0.1 2.1 0.1 0.0 0.0 0.0 0.2 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.2 29.4 0.0 0.0 0.0 0.0 0.2 32.6 0.0 0.0 0.0 0.0 0.0 0.0 4.6 0.0 0.3 0.0 0.0 1.5 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 37.1 73.6 26.1 45.7 38.9 36.9 29.0 32.0 26.0 25.5 31.6 34.1 7.9 0.0 0.0 3.3 3.4 0.1 0.0 0.0 0.0 2.2 23.7 40.6 300.7 5.7 0.0 18.4 0.0 0.0 0.5 0.0 1348.0 3.5 1.6 10.4 0.5 4.6 2.4 2.7 3.1 0.4 0.1 24.5 0.0 13.8 0.0 21.0 6.4 218.4 0.6 112.7 1.8 2.1 0.0 3.8 0.0 1.9 1.2 1.6 0.0 0.0 0.0 3.7 0.0 0.0 0.5 2.5 0.1 1.2 0.0 0.3 0.5 156.8 0.0 2.8 0.0 19.2 21.6 0.2 5.9 0.0 0.3 0.0 0.9 4.2 2.0 0.2 PPP1R1B "DARPP-32, FLJ20940" ENSG00000131771 "Protein phosphatase 1 regulatory inhibitor subunit 1B" Q9UD71 17 39626740-39636626 "Metabolic proteins, Predicted intracellular proteins" "Protein phosphatase inhibitor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 711.8;choroid plexus: 506.6;intestine: 211.4;salivary gland: 366.9" "Cell type enhanced" "Detected in many" "Distal enterocytes: 144.6;Distal tubular cells: 121.3;Intestinal goblet cells: 305.7;Melanocytes: 135.2;Paneth cells: 132.3;Undifferentiated cells: 423.7;Urothelial cells: 171.5" "Cancer enhanced" "Detected in many" "colorectal cancer: 94.8" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 11 "eosinophil: 1.0" "Lineage enriched" "Detected in single" 11 "granulocytes: 1.0" "Cell line enhanced" "Detected in some" "ASC diff: 7.6;CAPAN-2: 12.6;HSkMC: 31.7;OE19: 15.6;SCLC-21H: 27.4" "Region enriched" "Detected in all" 8 "basal ganglia: 1243.8" "Region enriched" "Detected in all" 26 "basal ganglia: 1534.8" "CAB004026, HPA048630, HPA061142" Approved Approved NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB004026: AB_2169007, HPA048630: AB_2680468, HPA061142: AB_2684438" "unprognostic (2.71e-1)" "unprognostic (4.09e-2)" "unprognostic (6.91e-3)" "unprognostic (2.42e-1)" "unprognostic (3.01e-1)" "unprognostic (7.69e-2)" "unprognostic (6.00e-3)" "unprognostic (2.76e-2)" "unprognostic (1.75e-2)" "unprognostic (6.13e-2)" "unprognostic (6.07e-2)" "unprognostic (2.04e-1)" "unprognostic (1.27e-1)" "unprognostic (2.67e-2)" "unprognostic (2.50e-2)" "unprognostic (2.52e-3)" "unprognostic (1.55e-1)" 93.8 30.2 280.9 19.8 711.8 0.4 74.0 262.7 312.7 20.0 506.6 211.4 83.4 4.4 5.5 4.8 28.4 2.0 3.5 251.7 244.0 29.1 0.5 15.3 0.1 319.6 275.5 11.3 75.7 0.5 15.0 0.0 232.4 62.7 203.4 6.2 366.9 89.7 0.9 56.3 68.7 10.8 243.3 0.1 39.9 15.8 317.9 0.2 0.6 0.0 0.3 18.9 11.4 249.6 0.0 0.0 0.0 0.0 7.6 4.4 0.2 0.0 0.0 0.0 0.0 0.0 12.6 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 31.7 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.8 0.9 15.6 0.9 0.0 0.0 0.6 0.0 0.0 27.4 0.6 0.0 1.5 0.0 2.4 0.6 1.1 0.0 0.0 1.8 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 280.9 711.8 262.7 312.7 251.7 244.0 319.6 275.5 232.4 243.3 317.9 249.6 1.0 0.0 34.7 33.3 1.3 1.3 117.1 0.4 0.6 0.6 93.5 84.3 1.1 0.0 0.2 1.8 0.0 0.0 2.4 144.6 121.3 28.7 0.8 46.6 0.9 1.6 96.7 0.0 5.3 3.3 0.0 2.8 13.3 3.2 4.5 0.0 4.2 0.0 0.2 0.0 1.6 305.7 2.0 0.0 0.8 3.2 34.5 1.2 135.2 0.0 0.0 29.8 0.0 1.0 0.5 0.8 132.3 5.7 0.0 84.3 40.4 0.7 0.1 1.3 0.0 1.2 1.7 0.9 3.7 1.2 0.4 0.0 1.9 0.0 423.7 171.5 PPP1R2 "IPP2, PPP1R2A" ENSG00000184203 "Protein phosphatase 1 regulatory inhibitor subunit 2" P41236 3 195514428-195543386 "Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Glycogen metabolism" "Protein phosphatase inhibitor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 431.9;Spermatocytes: 354.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "CACO-2: 142.1;U-266/70: 224.2" "Low region specificity" "Detected in all" "HPA043729, HPA059420" Approved Nucleoplasm,Cytosol NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 29: U-266 - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" Nucleoplasm Cytosol "HPA043729: AB_2678639, HPA059420: AB_2684009" "unprognostic (1.85e-2)" "unprognostic (3.71e-3)" "unprognostic (6.26e-2)" "unprognostic (3.58e-1)" "unprognostic (5.66e-2)" "unprognostic (1.44e-1)" "unprognostic (4.17e-2)" "unprognostic (3.92e-1)" "unprognostic (4.20e-2)" "unprognostic (2.00e-1)" "unprognostic (6.73e-2)" "unprognostic (8.32e-2)" "unprognostic (4.99e-2)" "unprognostic (2.28e-1)" "unprognostic (3.74e-1)" "unprognostic (2.71e-1)" "unprognostic (2.13e-1)" 18.3 15.0 15.4 21.3 16.2 68.1 22.6 12.9 16.9 18.0 16.5 22.8 25.8 21.2 25.2 22.4 18.3 19.7 24.7 16.6 21.0 21.0 15.0 17.4 29.1 15.1 15.4 13.9 13.5 16.8 15.6 17.5 17.2 20.9 19.8 16.0 16.9 19.1 85.8 17.2 22.3 21.6 14.3 21.5 17.7 29.2 15.2 28.2 23.1 56.2 25.2 21.1 18.2 15.0 43.8 9.8 14.7 17.0 24.1 25.8 29.1 25.8 36.6 26.4 22.6 142.1 18.0 17.3 99.2 31.1 27.8 18.1 15.1 25.6 32.1 33.0 30.3 18.6 14.0 47.5 37.2 20.5 18.8 31.4 19.4 19.7 39.6 20.8 23.0 17.1 14.7 33.4 23.4 32.3 34.4 22.9 15.6 49.2 42.1 16.6 25.6 50.4 31.8 32.1 34.9 20.0 31.6 33.1 46.5 27.0 52.5 19.9 27.9 16.9 19.3 28.8 36.7 224.2 105.7 79.5 23.9 37.0 33.3 120.6 64.7 257.5 71.8 68.2 98.2 100.3 149.3 99.1 68.8 95.8 178.6 122.8 152.3 94.2 69.0 103.5 168.4 129.2 15.4 16.2 12.9 16.9 16.6 21.0 15.1 15.4 17.2 14.3 15.2 15.0 106.9 22.4 47.8 13.1 165.7 94.2 138.6 70.1 89.4 51.5 80.6 61.5 53.5 38.6 56.3 22.0 58.4 67.7 148.2 48.6 125.2 69.5 431.9 119.5 65.0 99.6 57.4 33.6 30.8 66.3 43.0 62.5 45.3 67.9 111.0 26.7 51.0 27.1 61.0 52.2 41.7 48.5 69.2 73.3 170.6 243.8 51.6 103.4 97.8 25.3 120.9 50.5 74.2 23.1 19.1 74.5 65.1 63.6 188.4 123.0 77.3 106.0 80.3 91.1 26.3 48.7 71.1 354.3 92.4 88.2 77.6 103.2 230.1 58.0 54.7 186.2 PPP1R3A "GM, PPP1R3" ENSG00000154415 "Protein phosphatase 1 regulatory subunit 3A" Q16821 7 113876777-114075920 "Disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Carbohydrate metabolism, Glycogen metabolism" "Diabetes mellitus, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 64 "heart muscle: 40.8;skeletal muscle: 152.9;tongue: 104.1" "Cell type enriched" "Detected in some" 8 "Cardiomyocytes: 157.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 67 "THP-1: 14.6" "Region enriched" "Detected in single" 12 "thalamus: 1.1" "Not detected" "Not detected" "HPA070440, HPA073138" Enhanced NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 43: THP-1 - Innate immune response" "Cluster 54: Cardiomyocytes - Muscle contraction" "HPA070440: , HPA073138: " "unprognostic (8.96e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 40.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 1.0 0.0 152.9 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 104.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.6 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 157.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.3 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 16.9 0.8 0.6 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PPP1R3C "PPP1R5, PTG" ENSG00000119938 "Protein phosphatase 1 regulatory subunit 3C" Q9UQK1 10 91628442-91633071 "Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Glycogen metabolism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 908.0;tongue: 448.5" "Group enriched" "Detected in many" 8 "Astrocytes: 201.8;Cardiomyocytes: 232.0;Hepatocytes: 64.2;Muller glia cells: 133.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HeLa: 41.9;HHSteC: 51.7;hTERT-RPE1: 85.4;LHCN-M2: 102.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027041 Uncertain NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 54: Cardiomyocytes - Muscle contraction" "HPA027041: AB_1855649" "unprognostic (2.11e-1)" "unprognostic (1.86e-3)" "unprognostic (1.01e-1)" "unprognostic (2.44e-1)" "unprognostic (7.15e-3)" "unprognostic (1.57e-2)" "unprognostic (3.33e-2)" "unprognostic (6.38e-2)" "unprognostic (1.85e-2)" "unprognostic (1.75e-3)" "unprognostic (5.63e-3)" "unprognostic (1.59e-2)" "unprognostic (5.48e-3)" "unprognostic (8.44e-3)" "unprognostic (4.86e-2)" "unprognostic (2.49e-1)" "unprognostic (4.61e-3)" 14.1 12.2 39.3 3.4 51.5 0.0 9.9 39.8 44.6 97.1 21.4 16.2 4.0 10.3 12.0 106.8 10.2 14.4 170.5 40.1 42.9 11.6 164.2 12.3 1.4 44.1 55.1 10.2 18.7 4.5 5.7 15.6 43.9 29.1 4.1 83.2 28.4 35.7 908.0 17.0 5.8 15.4 39.6 3.0 17.5 2.5 42.4 0.5 2.7 448.5 6.2 19.8 136.7 38.0 0.0 6.6 1.8 26.8 11.9 5.6 0.0 29.8 23.2 12.0 12.8 0.0 2.2 0.0 1.2 28.0 4.8 1.6 0.7 3.2 22.0 0.0 0.1 0.4 41.9 4.8 51.7 0.0 0.0 19.1 5.2 7.6 0.4 85.4 3.0 0.0 14.4 0.0 102.5 1.0 0.0 0.0 1.7 0.0 0.0 0.0 6.4 0.0 1.1 26.2 0.9 1.8 0.0 0.0 0.0 0.0 0.2 4.5 20.3 5.3 5.2 7.0 4.3 0.2 0.6 0.0 30.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 39.3 51.5 39.8 44.6 40.1 42.9 44.1 55.1 43.9 39.6 42.4 38.0 2.4 0.0 0.0 201.8 0.4 4.6 9.3 0.8 0.6 9.7 4.8 2.5 232.0 1.5 0.2 3.7 0.0 0.2 0.0 0.3 7.9 3.1 0.1 0.3 0.7 3.5 10.1 0.0 1.7 11.4 0.5 11.9 0.0 0.6 0.0 0.4 2.5 64.2 1.4 18.5 3.0 0.5 2.0 1.6 1.5 0.1 2.8 0.6 12.4 5.6 0.0 133.1 0.0 3.5 0.5 4.0 0.1 7.5 0.0 2.5 0.0 1.8 0.4 12.8 0.0 9.4 18.6 0.7 1.7 5.4 4.0 0.3 0.7 0.1 0.1 0.7 PPP2CA "PP2AC, PP2Calpha" ENSG00000113575 "Protein phosphatase 2 catalytic subunit alpha" P67775 5 134194332-134226073 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Meiosis "Hydrolase, Protein phosphatase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003848, HPA043236" Approved NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 34: Non-specific - Transcription" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 22: Epithelial cell types - Mixed function" "CAB003848: AB_562203, HPA043236: AB_2678379" "unprognostic (1.44e-1)" "unprognostic (1.02e-1)" "unprognostic (1.60e-2)" "unprognostic (3.35e-3)" "unprognostic (1.26e-1)" "unprognostic (3.21e-2)" "prognostic unfavorable (7.33e-5)" "unprognostic (1.59e-3)" "unprognostic (1.57e-1)" "unprognostic (2.02e-1)" "unprognostic (1.34e-2)" "unprognostic (1.31e-1)" "unprognostic (5.24e-2)" "unprognostic (2.43e-1)" "unprognostic (1.43e-1)" "unprognostic (6.14e-2)" "unprognostic (1.57e-1)" 47.9 53.1 52.1 42.9 55.1 124.8 46.6 60.6 66.3 38.9 44.9 51.4 46.1 46.6 36.1 71.5 39.0 44.6 90.1 57.8 53.5 57.3 62.1 39.4 58.6 48.6 51.4 30.0 44.3 87.1 26.1 52.2 53.7 37.8 47.1 58.6 36.5 40.4 75.3 54.1 44.5 57.8 54.7 40.0 41.3 34.7 53.6 92.4 48.1 73.1 76.7 75.4 41.0 59.5 157.0 128.8 180.8 97.9 92.1 98.2 126.2 144.1 123.3 214.8 215.4 249.1 119.6 136.5 131.7 134.4 242.9 79.7 175.6 208.6 250.2 123.9 100.1 96.9 142.4 156.5 136.3 97.1 84.2 91.7 141.5 169.0 166.6 107.0 153.5 135.1 97.2 99.1 165.1 112.5 154.9 95.0 98.9 123.6 77.3 136.5 179.6 132.6 130.0 173.4 142.9 99.6 148.9 55.1 166.9 179.7 112.2 112.3 109.2 123.3 69.1 99.6 206.5 88.5 171.6 217.0 83.2 125.9 130.3 43.0 64.7 75.6 46.8 63.1 59.2 53.1 53.2 62.5 77.3 54.7 60.6 57.2 71.3 75.5 67.0 41.5 72.4 95.8 52.1 55.1 60.6 66.3 57.8 53.5 48.6 51.4 53.7 54.7 53.6 59.5 58.7 51.3 47.6 27.1 103.3 239.0 187.4 90.1 121.8 43.9 93.6 53.0 111.2 55.8 63.1 57.0 22.9 152.1 89.0 68.7 107.6 109.7 34.6 85.8 83.2 81.1 87.1 89.0 36.6 87.6 171.3 78.0 77.5 106.1 62.2 44.6 51.8 65.9 111.4 50.5 35.7 62.0 69.2 88.2 194.6 29.8 38.5 95.8 104.9 24.4 115.6 62.9 51.5 36.7 48.9 101.7 56.6 45.5 120.9 143.3 64.9 114.8 53.0 31.4 19.7 76.8 97.6 91.4 85.8 112.4 234.4 309.8 110.6 53.3 69.7 176.7 PPP2CB PP2Abeta ENSG00000104695 "Protein phosphatase 2 catalytic subunit beta" P62714 8 30774457-30814314 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Peritubular cells: 264.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB018600, HPA043236" Approved Supported Nucleoplasm NA NA "Cluster 6: Non-specific - Transcription" "Cluster 68: Epididymis - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "CAB018600: AB_675841, HPA043236: AB_2678379" "unprognostic (9.77e-2)" "unprognostic (1.30e-1)" "unprognostic (2.51e-2)" "unprognostic (3.82e-1)" "unprognostic (6.70e-2)" "unprognostic (7.79e-2)" "unprognostic (1.13e-2)" "unprognostic (3.51e-1)" "unprognostic (2.28e-1)" "unprognostic (2.86e-2)" "unprognostic (4.50e-2)" "unprognostic (1.89e-2)" "prognostic favorable (5.82e-7)" "unprognostic (9.24e-2)" "unprognostic (2.04e-1)" "unprognostic (1.39e-1)" "unprognostic (2.65e-3)" 89.9 66.6 190.2 42.2 196.1 10.5 68.4 189.1 220.1 84.0 147.9 79.3 72.9 112.1 117.1 95.1 87.8 74.2 94.7 191.6 190.7 131.9 118.6 90.6 32.5 199.7 184.1 147.4 75.7 93.3 52.5 91.0 190.4 74.9 76.2 77.9 68.6 87.1 105.7 63.7 87.0 122.3 195.1 52.9 71.2 64.7 204.4 41.4 126.7 122.7 47.4 76.8 70.0 200.1 96.5 82.7 136.4 54.4 134.6 120.0 78.0 124.0 114.0 123.1 129.5 86.6 68.3 45.6 118.7 165.4 117.9 56.5 84.4 142.1 167.3 28.5 44.2 61.8 52.7 86.9 157.3 28.1 34.2 108.6 157.4 105.2 115.9 124.2 152.5 73.6 97.7 47.6 212.4 48.4 77.1 34.9 102.6 139.3 47.0 53.9 55.7 34.5 168.5 73.6 134.3 55.0 57.8 61.1 127.0 150.5 34.1 47.8 164.0 109.1 81.7 36.1 105.5 24.0 33.6 53.7 93.4 26.0 141.4 3.4 2.5 1.7 1.8 3.1 2.3 2.9 1.7 1.9 1.7 1.1 1.7 2.1 2.3 3.8 1.5 3.8 1.3 0.8 190.2 196.1 189.1 220.1 191.6 190.7 199.7 184.1 190.4 195.1 204.4 200.1 81.0 70.5 60.7 68.6 13.0 104.1 115.9 44.4 44.9 36.6 64.9 51.8 80.2 45.8 54.3 86.5 31.3 41.1 23.6 186.1 46.9 40.6 21.8 98.5 109.8 60.9 32.3 16.6 41.0 48.9 52.8 79.0 34.7 89.2 17.7 95.4 87.8 95.5 58.4 47.1 59.1 65.3 28.5 55.4 60.4 20.3 73.3 36.0 40.9 52.5 27.4 127.2 17.5 37.7 60.4 81.1 78.9 264.0 15.8 125.4 115.6 95.9 68.2 26.5 46.0 93.1 73.0 37.2 40.4 50.3 95.6 70.6 17.4 75.3 41.2 149.9 PPP2R1A "PP2A-Aalpha, PP2AA, PR65A" ENSG00000105568 "Protein phosphatase 2 scaffold subunit Aalpha" P30153 19 52190048-52229518 "Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Chromosome partition" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB018599 Approved Cytosol NA NA 2000000 "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "CAB018599: AB_628178" "unprognostic (1.78e-1)" "unprognostic (2.31e-2)" "unprognostic (4.52e-2)" "unprognostic (2.87e-1)" "unprognostic (6.67e-2)" "unprognostic (7.82e-2)" "prognostic unfavorable (1.76e-4)" "prognostic unfavorable (2.50e-4)" "unprognostic (4.30e-2)" "unprognostic (3.06e-1)" "unprognostic (6.48e-3)" "unprognostic (8.28e-2)" "prognostic favorable (1.20e-4)" "unprognostic (1.97e-1)" "unprognostic (3.57e-2)" "unprognostic (1.70e-2)" "unprognostic (9.19e-2)" 98.5 300.7 305.0 60.5 311.1 58.1 98.7 292.0 394.2 126.9 261.4 115.7 91.5 126.8 101.0 164.4 126.8 63.2 322.8 342.6 299.4 156.9 106.0 87.5 72.7 308.9 301.1 163.7 100.7 129.9 123.9 69.1 312.8 123.3 82.2 89.8 99.8 92.2 239.7 119.3 98.5 96.0 280.1 87.6 106.0 67.2 331.7 76.9 107.9 170.7 90.0 123.5 121.9 299.2 153.6 248.4 210.9 182.0 166.9 173.4 105.3 130.3 173.2 174.1 151.1 129.3 122.1 132.5 91.0 213.9 95.7 108.8 228.0 197.9 100.6 101.3 562.8 99.6 126.9 148.2 152.6 105.6 93.1 234.3 163.8 163.5 149.2 162.9 167.9 92.1 114.3 96.8 196.3 178.6 159.6 215.4 204.6 162.2 218.4 148.6 118.3 152.5 285.0 251.7 153.3 161.3 149.0 160.1 100.3 136.3 141.9 197.3 153.1 133.2 120.5 65.7 154.2 96.9 151.5 160.0 143.1 109.7 170.5 172.6 172.0 169.4 143.9 212.2 131.0 143.1 126.3 134.3 192.8 157.1 101.6 119.6 103.7 228.6 199.0 119.7 177.5 255.6 305.0 311.1 292.0 394.2 342.6 299.4 308.9 301.1 312.8 280.1 331.7 299.2 55.3 44.8 35.4 21.5 76.0 70.4 99.0 178.0 56.9 114.0 64.5 71.1 100.2 74.4 99.5 119.5 25.0 203.7 47.3 157.0 117.4 213.5 4.4 77.5 79.7 72.4 107.0 39.7 27.4 155.7 259.9 85.7 77.5 100.7 68.5 96.7 65.0 52.8 146.2 144.7 39.5 128.8 144.5 68.1 39.3 10.4 72.4 58.0 53.4 17.8 103.7 118.0 62.8 25.6 29.9 168.2 189.0 85.4 60.3 88.3 147.5 135.3 80.6 61.5 78.9 49.2 90.3 16.5 68.8 74.4 63.2 182.0 64.2 99.7 185.2 104.2 PPP2R1B "PP2A-Abeta, PR65B" ENSG00000137713 "Protein phosphatase 2 scaffold subunit Abeta" P30154 11 111726908-111766389 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 170.7" "Cell type enhanced" "Detected in all" "Early spermatids: 306.1;Late spermatids: 160.7;Spermatocytes: 135.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 173.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004034, HPA018908" Approved Approved "Plasma membrane,Cytosol" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 85: Liver - Metabolism" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 66: Spermatocytes - Spermatogenesis" "Plasma membrane, Cytosol" "CAB004034: AB_490763, HPA018908: AB_1855655" "unprognostic (8.37e-2)" "unprognostic (3.87e-2)" "unprognostic (4.84e-3)" "unprognostic (3.27e-3)" "unprognostic (3.43e-1)" "unprognostic (4.93e-2)" "prognostic favorable (3.80e-4)" "unprognostic (4.58e-1)" "unprognostic (8.20e-3)" "unprognostic (2.26e-1)" "unprognostic (1.72e-1)" "unprognostic (8.41e-2)" "unprognostic (1.25e-3)" "unprognostic (1.25e-1)" "unprognostic (5.30e-1)" "unprognostic (2.12e-2)" "unprognostic (1.22e-1)" 58.5 10.5 11.3 14.1 18.0 16.2 21.5 20.0 13.9 13.0 17.3 14.7 13.9 8.7 8.1 12.6 8.0 13.4 6.3 11.7 13.8 14.6 170.7 8.8 12.1 14.7 13.7 13.3 33.2 12.9 10.7 9.2 14.2 7.7 14.7 8.5 9.6 6.1 9.6 10.7 15.2 7.8 10.6 6.3 22.3 54.0 13.8 15.9 10.6 8.9 14.1 12.2 7.4 20.7 38.4 25.1 35.6 24.2 34.9 18.7 35.8 37.2 25.9 27.0 24.6 86.0 39.3 48.3 27.1 24.1 25.6 35.4 53.4 30.5 34.3 33.7 16.6 47.2 14.5 37.8 17.3 55.7 36.1 21.5 18.1 30.6 22.2 19.1 33.8 49.7 58.3 62.3 30.1 12.4 60.8 22.6 43.8 41.4 27.3 45.9 23.6 58.6 40.2 41.9 11.6 31.4 33.1 30.2 6.1 38.3 35.0 20.6 36.7 31.3 37.8 15.6 23.9 6.6 17.4 173.8 11.1 63.9 40.7 6.1 10.1 10.4 13.0 11.7 12.7 10.0 12.9 12.1 14.9 12.5 11.2 12.0 2.6 15.3 11.4 6.4 15.0 12.2 11.3 18.0 20.0 13.9 11.7 13.8 14.7 13.7 14.2 10.6 13.8 20.7 21.2 19.2 10.5 63.3 11.0 14.3 11.0 12.0 18.2 5.4 14.1 8.5 3.2 15.7 13.4 12.9 8.4 13.5 11.0 23.8 13.7 18.7 306.1 29.6 13.4 20.2 15.6 32.4 23.8 22.9 20.3 12.3 15.3 46.1 8.2 34.3 9.3 89.4 9.5 1.7 14.5 11.5 22.4 5.8 9.2 160.7 6.5 7.5 8.8 17.8 8.9 9.9 7.2 26.2 49.1 23.6 9.0 7.5 9.0 10.9 16.2 17.6 16.8 11.0 13.1 14.5 14.4 135.9 20.8 12.0 14.6 17.6 11.0 9.7 13.9 15.0 PPP2R2A "B55A, B55alpha, PR52A, PR55A, PR55alpha" ENSG00000221914 "Protein phosphatase 2 regulatory subunit Balpha" P63151 8 26291508-26372680 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042122, HPA042770, CAB079289" Approved Approved Cytosol NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 59: Non-specific - Translation" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 22: Epithelial cell types - Mixed function" Cytosol "CAB079289: AB_659890, HPA042122: AB_2677859, HPA042770: AB_2678155" "unprognostic (1.17e-1)" "unprognostic (2.68e-2)" "unprognostic (4.29e-3)" "unprognostic (5.34e-2)" "unprognostic (3.44e-2)" "unprognostic (2.11e-2)" "unprognostic (4.64e-3)" "unprognostic (3.65e-1)" "unprognostic (2.48e-1)" "unprognostic (3.87e-2)" "unprognostic (2.71e-2)" "unprognostic (8.60e-2)" "unprognostic (1.60e-1)" "unprognostic (1.31e-1)" "unprognostic (2.90e-1)" "unprognostic (3.44e-2)" "unprognostic (1.16e-1)" 32.1 16.1 8.9 12.7 13.1 4.7 30.4 9.1 14.3 33.1 6.4 19.1 21.7 22.3 8.5 59.6 24.6 14.1 26.7 9.5 10.2 18.0 28.3 25.8 16.0 9.4 9.7 24.7 14.7 14.0 13.5 38.2 9.2 19.5 15.2 10.5 27.0 15.9 53.4 38.9 19.4 18.3 10.2 17.9 17.7 18.1 8.8 16.0 19.4 23.6 25.7 24.2 37.0 13.6 42.1 33.5 52.5 32.2 28.3 43.6 54.2 74.5 49.4 63.1 65.2 48.9 24.2 54.5 19.1 28.9 31.5 51.2 56.9 50.1 78.0 23.8 24.4 43.8 36.6 23.0 42.0 25.2 19.1 29.3 62.4 39.4 52.0 31.7 96.1 27.5 64.1 37.1 51.7 26.0 54.4 17.6 62.5 73.6 20.5 36.1 35.1 41.8 31.0 74.8 21.0 27.7 30.3 27.9 41.0 37.2 26.9 13.7 45.8 28.5 46.0 31.4 47.0 18.6 32.4 80.9 35.1 39.7 52.2 0.6 0.4 1.6 0.4 0.9 0.7 1.3 1.1 1.0 1.1 1.1 0.6 0.9 1.0 0.9 0.9 0.7 1.8 0.7 8.9 13.1 9.1 14.3 9.5 10.2 9.4 9.7 9.2 10.2 8.8 13.6 63.4 73.7 67.8 42.1 59.2 136.6 215.9 81.6 72.8 53.0 65.6 52.5 36.9 27.1 98.8 14.7 47.9 76.6 70.2 57.5 49.0 45.5 47.9 100.5 51.6 82.3 76.9 53.5 95.1 32.2 65.3 65.5 57.6 98.4 55.2 61.0 55.3 34.6 36.6 37.0 49.9 51.2 61.1 32.0 66.1 128.8 46.9 47.6 60.5 72.1 48.1 51.6 35.0 122.6 250.6 61.0 50.1 73.4 53.5 140.0 44.4 43.9 111.2 40.8 52.6 56.1 76.7 44.6 57.2 102.3 142.9 66.9 66.5 59.9 50.6 232.8 PPP2R2B "B55beta, PR52B, PR55-BETA, SCA12" ENSG00000156475 "Protein phosphatase 2 regulatory subunit Bbeta" Q00005 5 146580742-147084784 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" Apoptosis "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 77.1;retina: 43.0" "Cell type enhanced" "Detected in many" "Astrocytes: 1539.0;Excitatory neurons: 846.0;Inhibitory neurons: 788.8;Late spermatids: 876.4;Oligodendrocyte precursor cells: 1035.4;Oligodendrocytes: 4480.1" "Cancer enriched" "Detected in some" 8 "glioma: 7.1" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 6 "gdT-cell: 5.2;MAIT T-cell: 4.1;memory CD4 T-cell: 2.4;memory CD8 T-cell: 6.2;naive CD8 T-cell: 3.8;NK-cell: 2.9;T-reg: 3.4" "Group enriched" "Detected in many" 9 "NK-cells: 2.9;T-cells: 6.2" "Cell line enhanced" "Detected in some" "HaCaT: 7.2;HDLM-2: 24.2;RT4: 12.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038118, HPA042122, HPA042770" Approved Uncertain Cytosol NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 58: Brain - Synaptic function" "Cluster 44: HDLM-2 - Immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "HPA038118: AB_10697238, HPA042122: AB_2677859, HPA042770: AB_2678155" "unprognostic (4.54e-5)" "unprognostic (1.74e-1)" "unprognostic (1.21e-1)" "unprognostic (2.80e-4)" "unprognostic (2.48e-1)" "unprognostic (1.44e-1)" "unprognostic (2.76e-1)" "unprognostic (1.84e-2)" "unprognostic (2.68e-1)" "unprognostic (3.20e-2)" "unprognostic (9.73e-4)" "unprognostic (4.51e-2)" "unprognostic (1.49e-8)" "unprognostic (2.02e-1)" "unprognostic (3.67e-1)" "unprognostic (5.48e-5)" "unprognostic (1.14e-4)" 1.3 7.8 53.9 0.9 71.4 1.9 0.8 44.7 77.1 1.2 6.0 6.5 1.0 0.4 0.5 1.3 3.6 1.8 2.5 57.8 53.9 3.7 0.7 0.8 1.7 50.7 56.3 0.4 1.9 2.8 14.8 0.7 50.4 1.9 1.9 43.0 1.0 1.0 0.3 3.4 2.2 1.3 50.7 1.8 1.1 18.9 71.6 0.8 3.1 0.3 0.8 7.5 2.0 73.9 0.2 0.0 1.3 2.0 0.2 0.0 0.4 0.7 0.3 0.7 0.2 2.3 1.9 0.2 0.2 0.1 0.0 7.2 0.5 0.4 1.8 24.2 0.4 0.4 4.8 0.6 0.4 0.1 0.4 0.2 1.2 0.0 0.4 0.8 0.3 0.7 0.7 0.5 0.9 0.3 0.2 0.1 2.3 0.0 0.9 1.6 0.2 0.0 1.9 12.5 1.3 0.2 0.3 0.0 0.3 1.4 0.7 0.0 0.4 0.1 0.3 1.7 0.6 0.1 0.4 0.2 0.9 1.9 2.0 0.5 0.0 0.0 5.2 0.0 4.1 0.1 2.4 6.2 0.0 0.0 0.6 3.8 0.1 2.9 0.1 0.0 3.4 1.4 53.9 71.4 44.7 77.1 57.8 53.9 50.7 56.3 50.4 50.7 71.6 73.9 0.5 3.2 1.8 1539.0 0.3 2.0 1.1 2.3 4.6 90.5 0.5 3.6 1.6 10.0 0.9 9.2 150.1 18.9 30.2 0.0 21.5 1.7 295.3 1.0 0.1 2.0 13.1 1.3 846.0 0.0 0.3 1.1 1.1 0.4 0.0 0.0 0.0 0.0 0.9 47.1 788.8 0.0 0.0 1.2 4.7 876.4 3.4 1.4 5.4 58.1 0.3 45.0 57.7 1035.4 4480.1 0.6 0.0 2.2 3.3 1.0 0.0 5.5 0.1 275.4 0.0 0.7 11.0 4.8 2.2 1.6 1.4 5.3 31.0 0.1 0.0 0.9 PPP2R2C "B55gamma, IMYPNO, MGC33570, PR52, PR55G" ENSG00000074211 "Protein phosphatase 2 regulatory subunit Bgamma" Q9Y2T4 4 6320578-6563600 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 106.2" "Group enriched" "Detected in many" 5 "Astrocytes: 61.0;Early spermatids: 67.4;Excitatory neurons: 203.3;Inhibitory neurons: 82.8;Late spermatids: 182.5;Oligodendrocytes: 94.6" "Cancer enhanced" "Detected in many" "head and neck cancer: 10.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 31.4;A549: 46.1;CAPAN-2: 28.2;GAMG: 68.4;MCF7: 36.2;PC-3: 38.9;SCLC-21H: 39.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042122, HPA042770, HPA060473" Approved Approved Cytosol NA NA "Cluster 27: Brain & Skin - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "HPA042122: AB_2677859, HPA042770: AB_2678155, HPA060473: AB_2684291" "unprognostic (9.39e-2)" "unprognostic (7.10e-2)" "unprognostic (9.12e-2)" "unprognostic (1.14e-3)" "unprognostic (1.48e-1)" "unprognostic (5.91e-2)" "unprognostic (2.70e-4)" "prognostic unfavorable (4.94e-4)" "unprognostic (1.77e-1)" "unprognostic (3.90e-1)" "unprognostic (4.67e-2)" "unprognostic (2.77e-1)" "unprognostic (1.36e-13)" "unprognostic (2.52e-1)" "unprognostic (3.92e-2)" "unprognostic (2.66e-3)" "unprognostic (9.90e-3)" 0.8 6.2 72.9 0.6 86.7 0.0 1.4 42.1 106.2 18.0 0.0 1.1 0.8 27.0 7.4 35.9 9.9 0.4 2.5 85.7 44.5 0.3 0.1 0.1 0.3 52.5 52.7 0.6 0.7 1.5 22.6 0.1 55.1 5.0 0.3 10.9 5.3 14.5 0.8 34.0 1.2 11.9 62.3 0.3 0.8 7.3 66.9 2.7 0.1 0.9 3.1 0.9 11.5 91.2 31.4 46.1 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 28.2 0.0 19.0 0.0 68.4 13.7 20.0 0.7 0.0 0.0 2.4 0.0 3.2 3.7 0.7 0.0 0.1 6.6 11.4 0.0 0.0 0.0 0.1 4.2 0.0 0.1 6.6 36.2 0.0 0.1 2.2 0.6 38.9 0.0 0.0 1.2 0.0 0.1 39.1 7.5 1.5 0.1 0.0 1.1 18.9 0.1 0.0 0.2 22.7 0.0 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 72.9 86.7 42.1 106.2 85.7 44.5 52.5 52.7 55.1 62.3 66.9 91.2 0.2 0.0 0.0 61.0 0.0 14.7 0.4 0.8 4.6 11.0 1.9 0.4 4.0 0.0 0.2 0.0 0.0 0.0 0.1 0.1 0.0 0.0 67.4 0.8 5.7 0.6 0.0 0.0 203.3 0.2 0.0 0.2 0.0 2.4 0.0 0.0 0.0 0.0 0.1 3.3 82.8 0.0 0.0 0.0 1.1 182.5 6.8 0.0 0.0 4.7 0.0 6.5 0.0 14.1 94.6 2.4 0.0 4.5 0.0 1.3 0.0 0.2 0.0 3.1 0.0 0.0 2.5 2.3 1.6 6.5 22.0 0.0 0.2 0.1 0.0 0.2 PPP2R3A "PPP2R3, PR130, PR72" ENSG00000073711 "Protein phosphatase 2 regulatory subunit B''alpha" Q06190 3 135965728-136147894 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "heart muscle: 51.2;skeletal muscle: 180.5;tongue: 117.6" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 115.3;Oligodendrocytes: 201.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 37.4;BJ hTERT+: 35.3;RPTEC TERT1: 46.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035829, HPA035830, HPA065338" Uncertain Approved "Golgi apparatus" NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 54: Cardiomyocytes - Muscle contraction" "Golgi apparatus" "HPA035829: AB_10696513, HPA035830: AB_10670121, HPA065338: AB_2685475" "unprognostic (3.35e-1)" "unprognostic (2.37e-2)" "unprognostic (1.71e-1)" "prognostic unfavorable (4.38e-4)" "unprognostic (1.71e-1)" "unprognostic (4.04e-1)" "unprognostic (1.44e-4)" "unprognostic (9.43e-2)" "unprognostic (1.27e-1)" "unprognostic (5.70e-2)" "prognostic unfavorable (1.14e-5)" "unprognostic (8.92e-2)" "prognostic favorable (1.15e-5)" "unprognostic (4.55e-2)" "unprognostic (3.06e-2)" "unprognostic (1.01e-1)" "prognostic unfavorable (3.91e-4)" 3.1 3.4 3.3 2.3 7.2 0.2 7.1 4.3 5.0 5.2 3.9 8.0 2.0 7.7 5.1 8.3 4.1 5.0 51.2 4.2 4.9 22.0 1.1 3.9 0.6 5.7 5.5 5.6 3.4 11.7 1.8 2.8 5.3 5.9 5.4 2.6 8.9 6.5 180.5 18.9 2.3 9.6 4.3 1.1 7.4 7.2 6.0 0.6 3.1 117.6 1.2 4.5 4.0 13.7 37.4 2.0 10.3 5.0 8.1 10.2 11.9 28.5 35.3 13.2 16.3 2.4 2.4 0.1 10.7 29.3 9.5 4.7 4.3 10.0 28.3 0.1 1.4 1.6 1.0 0.1 5.8 0.0 1.4 9.3 8.5 16.8 7.8 13.3 12.8 1.0 1.0 0.1 19.2 6.2 0.3 0.2 7.2 0.4 6.9 0.1 15.1 0.1 46.2 1.4 0.7 5.7 4.7 5.7 10.9 9.2 9.1 0.5 8.4 13.7 7.5 18.8 12.7 0.4 1.0 0.1 10.1 0.8 4.9 0.1 0.1 0.2 0.1 0.1 0.0 0.0 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.2 0.1 0.0 3.3 7.2 4.3 5.0 4.2 4.9 5.7 5.5 5.3 4.3 6.0 13.7 7.9 28.9 27.6 51.6 2.8 26.4 19.5 7.1 19.4 5.7 19.9 15.5 115.3 8.6 10.0 55.2 0.0 10.9 6.7 25.3 21.5 20.6 8.4 9.9 19.0 11.4 13.1 0.4 35.2 9.9 15.4 14.8 21.9 16.1 3.8 15.7 8.6 2.9 2.5 3.3 47.2 6.9 6.1 2.4 9.8 10.7 24.5 3.2 28.4 13.1 9.6 8.9 2.1 72.4 201.1 17.2 10.6 18.4 1.5 17.8 21.7 40.1 8.1 2.6 6.6 29.0 14.0 10.1 18.6 15.3 33.2 10.4 3.4 6.7 8.9 15.6 PPP2R3B "PPP2R3L, PPP2R3LY, PR48, PR70" ENSG00000167393 "Protein phosphatase 2 regulatory subunit B''beta" Q9Y5P8 X 333933-386955 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "heart muscle: 73.0;skeletal muscle: 103.4" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 72.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "PC-3: 18.5;U-698: 29.9" HPA026606 Supported Nucleoplasm,Cytosol NA NA "Cluster 59: Non-specific - Translation" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm Cytosol "HPA026606: " "unprognostic (1.25e-1)" "unprognostic (4.35e-3)" "unprognostic (5.10e-2)" "unprognostic (1.16e-1)" "unprognostic (6.03e-2)" "unprognostic (2.46e-3)" "unprognostic (1.56e-2)" "unprognostic (2.73e-2)" "unprognostic (1.75e-1)" "unprognostic (1.79e-2)" "prognostic favorable (2.92e-5)" "unprognostic (4.65e-2)" "unprognostic (2.29e-8)" "unprognostic (1.15e-1)" "unprognostic (4.97e-2)" "unprognostic (3.17e-1)" "prognostic favorable (1.90e-5)" 4.4 4.7 1.2 0.2 1.2 1.9 4.9 0.8 1.6 8.3 0.8 4.0 0.5 6.9 0.0 9.5 9.3 0.3 73.0 1.0 1.6 4.0 3.7 3.9 0.6 1.5 1.7 7.6 4.5 0.2 10.3 0.6 1.5 9.1 0.0 0.1 7.1 0.3 103.4 16.5 4.7 0.3 1.2 7.2 4.6 16.3 1.4 1.3 5.0 2.6 0.0 11.8 7.7 1.8 1.0 5.0 0.6 1.9 0.1 0.1 8.1 7.6 1.3 4.7 6.0 5.4 0.0 1.8 4.0 5.4 0.7 0.0 0.1 0.0 1.0 5.6 6.3 1.1 1.8 0.3 0.0 2.3 3.1 0.2 0.1 0.0 3.7 0.4 0.1 3.3 1.6 0.2 0.7 3.1 11.8 8.6 3.1 0.1 18.5 5.3 3.7 0.4 1.0 1.4 0.0 11.1 0.0 0.6 5.3 4.0 0.0 1.7 0.4 2.5 3.6 0.0 2.0 0.2 0.4 29.9 0.0 2.6 4.8 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 1.2 0.8 1.6 1.0 1.6 1.5 1.7 1.5 1.2 1.4 1.8 6.7 0.0 1.7 11.4 3.8 6.8 8.6 1.7 4.6 13.5 8.5 10.7 72.3 4.3 2.1 0.0 27.1 5.2 5.7 3.8 0.0 2.5 0.6 12.1 4.6 5.4 4.8 4.8 2.8 4.0 7.3 8.0 4.6 7.4 0.0 25.6 2.9 1.8 3.7 6.7 3.7 3.9 0.0 2.8 4.5 2.0 4.1 5.8 5.4 5.6 3.1 8.6 6.2 17.6 10.4 2.4 0.6 3.0 3.3 3.7 1.8 1.7 4.3 19.0 0.0 12.2 6.5 16.7 27.1 6.1 7.5 4.0 5.0 7.8 3.6 4.5 PPP3CA "CALN, CALNA, CNA1, PPP2B" ENSG00000138814 "Protein phosphatase 3 catalytic subunit alpha" Q08209 4 101023409-101348278 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Calmodulin-binding, Hydrolase, Protein phosphatase" "Craniosynostosis, Disease variant, Dwarfism, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 144.1" "Cell type enhanced" "Detected in all" "Excitatory neurons: 933.8;Inhibitory neurons: 403.0;Oligodendrocyte precursor cells: 348.3" "Cancer enriched" "Detected in all" 7 "prostate cancer: 98.1" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012778, CAB018581" Enhanced Enhanced Nucleoplasm,Cytosol NA NA 94000 "Cluster 49: Eosinophils - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm Cytosol "CAB018581: AB_2168324, HPA012778: AB_1855660" "unprognostic (6.66e-2)" "unprognostic (1.96e-1)" "unprognostic (3.40e-1)" "unprognostic (1.36e-1)" "unprognostic (1.56e-1)" "unprognostic (7.81e-2)" "unprognostic (1.77e-2)" "unprognostic (1.08e-1)" "unprognostic (7.87e-2)" "unprognostic (3.49e-3)" "prognostic unfavorable (3.82e-4)" "unprognostic (3.38e-2)" "unprognostic (2.51e-2)" "unprognostic (5.12e-2)" "unprognostic (1.98e-1)" "unprognostic (1.84e-2)" "unprognostic (5.74e-2)" 24.7 17.5 48.5 15.7 144.1 17.2 20.5 63.2 125.6 17.0 0.0 19.5 11.6 11.8 13.1 14.4 13.8 13.3 9.2 97.4 25.0 11.2 17.0 19.9 14.7 14.6 11.0 17.9 9.4 8.9 9.0 13.0 15.7 66.0 16.1 27.6 22.2 38.4 51.2 22.9 12.9 15.5 24.7 14.5 22.4 10.6 23.9 12.8 13.2 29.0 18.3 20.7 16.0 54.3 48.3 33.8 9.3 18.0 50.4 37.9 15.8 51.9 47.8 19.8 21.6 18.3 59.0 22.4 20.9 47.6 25.6 23.5 33.3 69.6 34.9 56.0 15.1 35.4 45.8 25.2 36.8 59.0 17.8 39.6 35.6 45.3 51.4 39.1 38.8 14.5 14.4 61.1 33.5 58.0 12.2 44.2 15.4 55.7 20.7 22.1 83.2 26.5 20.0 38.3 71.5 26.2 43.1 35.4 24.6 12.5 32.3 33.4 42.1 48.7 54.8 44.7 34.7 28.5 31.5 40.1 26.6 31.5 13.1 82.5 31.0 73.5 35.7 33.1 41.6 74.1 33.2 34.8 28.2 62.8 15.5 31.0 123.7 65.1 45.1 51.9 25.3 21.1 48.5 144.1 63.2 125.6 97.4 25.0 14.6 11.0 15.7 24.7 23.9 54.3 143.3 76.9 58.6 284.1 96.8 168.8 36.2 29.5 34.7 89.8 93.8 51.8 25.0 38.6 21.9 31.3 39.6 39.6 81.4 60.0 33.2 21.3 3.2 39.3 56.2 100.8 127.4 32.0 933.8 31.6 84.0 75.6 59.1 42.8 35.4 22.1 53.2 39.7 38.3 18.5 403.0 44.2 14.2 61.8 135.3 8.4 65.0 58.2 92.5 281.1 64.3 21.2 56.7 348.3 139.1 53.3 115.4 60.9 63.8 127.6 23.9 51.9 25.3 82.9 13.1 66.9 67.5 12.7 26.5 27.9 172.0 27.5 69.1 76.2 55.9 39.5 PPP3CB "CALNA2, CALNB, CNA2, PP2Bbeta" ENSG00000107758 "Protein phosphatase 3 catalytic subunit beta" P16298 10 73436433-73496024 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Calmodulin-binding, Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 4 "skeletal muscle: 379.3;tongue: 179.7" "Cell type enhanced" "Detected in all" "Excitatory neurons: 119.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008233, HPA008823" Uncertain Approved Mitochondria NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 10: Non-specific - Unknown function" Mitochondria "HPA008233: AB_1855661, HPA008823: AB_2668148" "unprognostic (3.05e-1)" "unprognostic (2.54e-1)" "unprognostic (1.50e-1)" "unprognostic (4.93e-2)" "unprognostic (8.93e-2)" "unprognostic (4.28e-2)" "prognostic unfavorable (9.59e-4)" "unprognostic (1.14e-1)" "unprognostic (1.34e-1)" "unprognostic (2.12e-2)" "prognostic favorable (6.96e-5)" "unprognostic (4.73e-2)" "unprognostic (1.51e-1)" "unprognostic (1.01e-1)" "unprognostic (1.45e-1)" "unprognostic (2.66e-1)" "unprognostic (1.68e-2)" 44.8 37.5 40.5 29.8 51.1 19.8 32.1 49.5 63.1 30.3 26.7 41.4 24.2 40.3 34.5 33.1 30.9 28.3 41.3 56.9 29.5 28.1 21.8 23.5 34.9 25.4 25.2 39.6 25.3 39.2 30.6 25.5 28.7 39.1 29.6 57.0 26.6 39.8 379.3 26.3 22.6 48.2 27.2 25.3 24.3 29.0 29.1 32.9 23.5 179.7 36.1 34.3 24.3 44.9 53.7 29.0 50.9 53.0 71.4 98.3 24.5 48.0 65.7 46.1 45.4 18.6 26.8 47.1 15.3 70.0 21.8 28.1 41.6 36.9 64.5 66.6 34.0 20.3 25.0 35.5 42.7 45.2 40.2 70.1 43.5 43.6 58.1 84.7 32.3 40.6 25.6 54.0 94.1 16.9 40.7 41.6 20.7 23.3 83.8 26.9 27.7 22.4 45.1 25.6 27.2 31.5 28.1 69.5 36.4 42.1 52.4 43.2 35.6 36.6 33.7 29.5 66.1 35.8 105.3 33.0 45.3 64.0 21.3 2.2 2.0 3.5 4.0 2.7 4.8 2.7 4.3 4.4 2.1 2.3 3.4 5.1 1.1 3.5 1.7 4.0 7.8 1.9 40.5 51.1 49.5 63.1 56.9 29.5 25.4 25.2 28.7 27.2 29.1 44.9 23.0 3.2 14.3 72.5 31.6 25.6 29.8 13.2 27.3 54.8 25.7 16.9 48.9 14.3 12.8 18.4 20.9 21.0 23.7 11.1 62.6 18.1 11.8 20.0 24.2 21.5 42.6 30.7 119.5 19.4 16.8 32.6 20.4 18.8 21.0 35.4 18.9 14.2 20.3 38.7 111.0 13.2 18.3 31.7 24.2 9.9 33.5 25.2 26.6 51.5 29.6 34.8 18.6 79.4 54.4 16.7 12.9 29.0 34.1 27.1 13.4 34.2 17.6 30.1 6.6 41.8 36.4 43.8 49.2 32.1 31.5 22.2 27.3 28.4 13.1 22.1 PPP3CC "CALNA3, PP2Bgamma" ENSG00000120910 "Protein phosphatase 3 catalytic subunit gamma" P48454 8 22440819-22541142 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Calmodulin-binding, Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 145.8;Spermatocytes: 131.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023396, CAB024950" Approved Approved Vesicles NA NA "Cluster 35: T-regs - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 59: Non-specific - Transcription" Vesicles "CAB024950: , HPA023396: AB_1855663" "unprognostic (7.66e-3)" "unprognostic (1.61e-2)" "unprognostic (1.55e-1)" "unprognostic (1.01e-1)" "unprognostic (1.38e-1)" "unprognostic (2.21e-2)" "unprognostic (7.71e-2)" "prognostic favorable (6.80e-5)" "unprognostic (9.25e-2)" "unprognostic (1.97e-1)" "unprognostic (8.84e-2)" "unprognostic (4.05e-2)" "unprognostic (7.16e-2)" "unprognostic (2.35e-2)" "unprognostic (4.00e-1)" "unprognostic (2.78e-2)" "unprognostic (1.64e-2)" 28.5 11.9 11.8 16.5 11.8 26.5 20.8 17.7 15.3 18.1 31.1 16.6 9.1 14.5 10.6 16.9 15.6 15.7 34.5 11.3 10.8 12.9 12.4 21.5 33.0 12.1 11.0 14.0 14.3 18.4 11.7 19.3 12.2 14.4 10.3 77.9 14.0 8.2 89.4 13.6 15.4 15.5 10.0 22.4 14.6 56.0 13.1 15.0 16.6 54.2 26.9 17.0 16.4 14.8 12.2 8.8 7.7 9.4 19.8 24.4 11.2 16.5 28.9 23.9 26.5 5.1 7.5 45.7 19.7 25.6 40.0 8.4 17.9 16.5 30.5 26.3 9.5 9.8 10.5 14.7 26.8 7.1 15.6 15.0 22.3 16.2 16.5 25.6 21.1 22.0 19.6 58.8 27.2 5.7 16.8 11.7 5.6 12.5 12.0 54.0 18.1 15.2 22.4 11.3 5.4 12.7 12.3 7.4 17.4 14.4 4.9 11.8 22.8 37.1 7.9 56.7 12.9 29.3 38.5 48.3 19.6 9.3 25.1 5.4 2.7 10.7 16.6 3.2 12.7 26.3 19.0 23.6 5.1 21.3 18.1 14.9 0.6 19.2 4.7 6.2 17.2 7.1 11.8 11.8 17.7 15.3 11.3 10.8 12.1 11.0 12.2 10.0 13.1 14.8 27.2 6.4 5.1 49.6 74.7 16.6 21.3 32.6 12.0 12.8 10.0 6.0 8.0 14.3 14.0 7.3 47.9 18.0 50.3 6.7 7.9 15.0 145.8 6.5 12.7 24.2 10.3 10.8 78.9 21.0 23.8 25.1 6.6 14.6 3.8 3.9 23.6 7.8 13.1 3.3 83.6 2.5 38.7 10.8 24.6 22.6 22.4 19.3 28.4 76.8 30.4 13.1 59.8 99.5 64.8 21.1 7.4 21.4 96.8 26.3 10.6 11.6 7.8 50.5 32.9 19.5 23.3 131.8 29.6 17.1 11.4 14.1 53.4 4.8 6.3 25.5 PPP3R1 "CALNB1, CNB, CNB1" ENSG00000221823 "Protein phosphatase 3 regulatory subunit B, alpha" P63098 2 68178857-68256237 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "retina: 189.9" "Cell type enhanced" "Detected in all" "Excitatory neurons: 151.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 2.7" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005610, HPA047157" Approved Supported "Plasma membrane,Cytosol" NA NA 42000 "Cluster 46: Basophils - DNA binding" "Cluster 58: Brain - Synaptic function" "Cluster 36: HEL - Hemostasis" "Cluster 59: Non-specific - Transcription" "Plasma membrane" Cytosol "CAB005610: AB_325975, HPA047157: AB_2679960" "unprognostic (2.12e-1)" "unprognostic (2.09e-2)" "unprognostic (1.55e-1)" "prognostic unfavorable (9.08e-6)" "unprognostic (5.90e-2)" "unprognostic (1.86e-1)" "prognostic unfavorable (5.37e-4)" "unprognostic (3.59e-1)" "unprognostic (3.96e-2)" "unprognostic (1.28e-1)" "unprognostic (1.13e-2)" "unprognostic (1.74e-1)" "prognostic unfavorable (1.70e-5)" "unprognostic (5.24e-3)" "unprognostic (5.35e-1)" "unprognostic (8.70e-2)" "unprognostic (1.24e-1)" 53.7 37.7 56.1 32.4 92.9 73.6 27.1 38.0 127.3 27.3 0.0 27.6 25.7 31.0 26.1 30.0 23.3 28.0 20.6 99.0 24.2 21.4 58.2 27.7 40.2 23.5 18.4 24.9 20.7 17.0 18.3 36.6 24.9 26.3 27.8 189.9 24.9 30.1 88.8 33.6 23.9 35.3 14.4 34.2 24.8 20.6 30.0 42.6 23.8 31.0 40.5 32.9 28.6 64.5 61.5 51.7 69.7 48.4 47.4 54.3 70.5 86.3 75.9 98.8 86.8 75.9 55.4 85.7 28.7 61.4 69.5 41.8 74.4 64.8 120.0 59.4 52.9 284.0 38.3 71.1 93.1 111.9 92.2 55.1 57.6 76.9 78.0 55.9 67.2 72.2 67.8 96.8 73.2 53.8 96.1 99.4 81.9 52.0 44.4 69.1 90.6 139.9 61.7 66.1 91.4 64.2 50.4 72.3 65.9 45.0 33.9 51.8 69.5 84.6 76.5 64.2 75.1 53.8 62.6 124.7 61.3 115.2 54.0 1.5 0.5 1.3 0.2 0.3 0.5 0.2 0.3 0.1 0.5 0.3 0.3 0.5 2.7 0.3 0.6 0.7 0.3 0.4 56.1 92.9 38.0 127.3 99.0 24.2 23.5 18.4 24.9 14.4 30.0 64.5 37.0 9.6 12.7 81.6 40.4 74.8 11.6 7.0 72.8 22.2 21.0 13.1 17.9 10.0 7.7 16.5 52.1 11.7 34.0 20.5 11.7 7.1 20.0 19.9 23.0 34.0 15.1 52.8 151.2 8.7 17.2 24.2 18.8 29.1 19.7 11.2 15.4 19.2 24.7 11.8 93.1 15.6 4.1 40.0 105.1 7.7 9.9 54.7 35.6 105.9 21.2 27.8 18.6 72.9 77.5 12.9 10.6 8.6 39.2 17.3 12.6 20.1 5.8 92.7 13.1 14.4 29.8 2.9 6.1 64.0 70.5 12.0 39.9 14.2 13.2 21.3 PPP3R2 PPP3RL ENSG00000188386 "Protein phosphatase 3 regulatory subunit B, beta" Q96LZ3 9 101591604-101595021 "FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 161 "testis: 80.8" "Group enriched" "Detected in some" 38 "Early spermatids: 399.2;Late spermatids: 198.3;Spermatocytes: 600.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA047157 Uncertain Approved "Plasma membrane,Cytosol" NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 66: Spermatocytes - Spermatogenesis" "Plasma membrane" Cytosol "HPA047157: AB_2679960" "unprognostic (8.81e-2)" "unprognostic (2.65e-1)" 0.0 0.0 0.3 0.0 0.2 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 80.8 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.5 0.1 0.0 0.4 0.1 0.4 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 399.2 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 198.3 10.5 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.2 0.0 0.0 0.0 0.0 0.0 0.0 6.6 0.1 0.2 600.6 3.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PPP4C "PP4, PPX" ENSG00000149923 "Protein phosphatase 4 catalytic subunit" P60510 16 30075978-30085376 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043837 Supported Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "Plasma membrane, Cytosol" "HPA043837: AB_2678695" "unprognostic (1.20e-1)" "unprognostic (1.33e-2)" "unprognostic (2.68e-1)" "unprognostic (4.74e-2)" "unprognostic (2.16e-1)" "unprognostic (5.79e-3)" "unprognostic (3.28e-3)" "unprognostic (2.60e-3)" "unprognostic (3.82e-1)" "unprognostic (1.29e-1)" "unprognostic (2.52e-1)" "unprognostic (3.17e-2)" "unprognostic (1.98e-2)" "unprognostic (3.78e-2)" "unprognostic (9.36e-2)" "unprognostic (9.96e-2)" "unprognostic (1.88e-1)" 44.3 57.9 34.8 43.2 34.7 63.2 42.5 35.9 38.7 42.8 41.0 49.8 47.0 39.6 47.1 88.3 35.9 32.5 45.6 34.0 35.7 49.9 83.2 46.2 58.6 35.5 34.9 29.4 41.0 46.4 33.5 49.6 35.3 37.8 35.2 18.1 44.0 28.5 60.8 60.8 49.0 32.8 35.6 62.5 49.2 65.4 38.4 61.2 35.4 30.2 63.7 56.3 48.9 36.4 132.7 145.9 95.5 134.0 88.4 73.8 148.5 115.8 127.7 148.7 163.8 129.5 167.9 102.7 145.2 137.0 95.5 105.9 119.3 143.2 87.0 130.1 213.0 70.5 86.0 290.4 133.5 100.1 126.8 107.9 124.7 135.9 85.5 88.4 174.9 130.5 139.6 91.0 115.1 382.2 174.4 180.7 182.2 104.7 77.1 190.9 99.4 180.4 142.5 134.5 91.9 136.8 57.1 169.1 101.8 79.4 156.0 166.0 113.3 86.4 90.4 70.6 90.8 155.4 183.8 122.4 123.1 126.9 107.0 100.6 103.5 236.1 66.5 113.2 47.7 68.5 69.6 74.2 115.8 88.3 62.0 54.1 215.2 51.7 100.1 90.6 95.1 48.3 34.8 34.7 35.9 38.7 34.0 35.7 35.5 34.9 35.3 35.6 38.4 36.4 87.8 51.3 33.4 10.7 85.8 147.2 121.7 206.9 71.2 23.3 94.2 82.8 11.1 82.9 133.5 77.3 29.2 313.7 106.0 217.0 158.5 226.9 156.9 80.5 55.5 91.7 125.6 89.2 8.0 193.3 335.3 66.7 106.0 85.2 69.2 66.7 74.6 94.2 239.3 35.3 8.6 159.3 193.3 105.4 138.4 143.8 62.7 124.4 80.0 9.4 221.1 61.1 118.4 8.0 12.9 345.5 220.8 52.3 97.6 161.3 191.0 198.6 119.7 29.5 72.3 43.4 85.9 228.5 157.8 113.2 172.5 421.0 93.0 61.7 175.9 227.2 PPP5C "PP5, PPP5" ENSG00000011485 "Protein phosphatase 5 catalytic subunit" P53041 19 46347087-46392981 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair" "Hydrolase, Protein phosphatase" "Alzheimer disease, Amyloidosis, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022641, HPA029065, HPA056933" Approved Supported Vesicles,Cytosol NA NA 120000 "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 24: NB-4 - Immune response" "Cluster 59: Non-specific - Transcription" "Vesicles, Cytosol" "CAB022641: , HPA029065: AB_10610284, HPA056933: AB_2683278" "unprognostic (8.25e-2)" "unprognostic (7.90e-2)" "unprognostic (1.44e-1)" "unprognostic (6.30e-2)" "unprognostic (5.92e-2)" "unprognostic (2.62e-2)" "prognostic unfavorable (3.45e-6)" "unprognostic (1.29e-1)" "unprognostic (1.04e-2)" "unprognostic (8.25e-2)" "unprognostic (5.56e-2)" "unprognostic (2.20e-2)" "unprognostic (3.24e-2)" "unprognostic (1.14e-1)" "unprognostic (1.35e-1)" "unprognostic (5.92e-3)" "unprognostic (1.37e-1)" 27.4 37.5 27.7 17.7 29.3 14.2 26.3 28.4 36.5 28.0 27.7 31.3 16.8 34.9 9.8 30.4 31.7 13.3 56.4 29.8 28.6 29.1 32.7 28.0 19.7 32.3 28.2 24.7 23.7 32.5 36.6 15.8 33.3 23.7 15.4 14.4 23.0 18.2 58.9 27.5 25.9 20.8 26.2 33.5 33.6 16.9 30.3 20.5 26.2 45.7 15.0 27.7 26.3 28.5 61.9 114.9 66.0 50.1 48.3 50.9 30.6 75.4 59.6 88.2 78.2 82.4 47.9 94.3 39.9 54.0 48.4 49.9 86.2 88.5 24.7 65.9 120.5 76.4 80.9 59.4 54.5 106.6 52.8 47.8 40.9 62.1 45.9 34.2 77.2 79.3 76.0 47.3 49.4 67.5 59.5 203.4 50.2 109.6 61.7 89.0 56.6 76.5 52.8 81.8 93.1 69.7 62.6 78.8 26.9 28.6 49.7 67.8 65.5 38.3 64.3 29.1 79.1 38.0 93.0 111.5 41.7 89.4 65.9 0.0 10.3 3.0 27.8 18.0 17.8 15.1 12.8 22.0 16.8 11.7 12.2 16.8 0.2 22.0 23.4 11.7 14.3 15.4 27.7 29.3 28.4 36.5 29.8 28.6 32.3 28.2 33.3 26.2 30.3 28.5 28.1 6.4 12.5 22.9 16.5 9.4 16.6 20.9 19.9 19.7 13.1 13.5 5.6 44.3 14.2 16.5 16.7 26.4 12.3 25.2 33.2 29.9 1.2 31.3 25.2 19.6 14.9 11.6 18.5 19.5 36.2 17.6 26.0 19.6 4.5 18.6 24.3 24.9 21.6 16.8 23.2 17.0 22.4 12.3 8.2 3.2 17.4 11.9 16.0 11.2 12.1 21.0 17.5 17.6 14.5 26.4 17.0 18.4 25.5 12.1 16.3 21.4 14.6 17.9 39.5 14.6 19.9 26.6 32.0 20.8 13.2 25.7 20.4 23.1 25.0 11.7 PPP6C PP6 ENSG00000119414 "Protein phosphatase 6 catalytic subunit" O00743 9 125146573-125189939 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Immunity, Innate immunity" "Hydrolase, Protein phosphatase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA050940 Uncertain NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 8: Non-specific - Mitochondria" "Cluster 16: U-266 - Nucleosome" "Cluster 59: Non-specific - Transcription" "HPA050940: AB_2681283" "unprognostic (6.45e-2)" "unprognostic (4.01e-3)" "unprognostic (7.12e-2)" "unprognostic (5.36e-2)" "unprognostic (2.78e-2)" "unprognostic (2.92e-2)" "unprognostic (2.57e-3)" "unprognostic (1.53e-1)" "unprognostic (2.14e-1)" "unprognostic (2.44e-1)" "unprognostic (1.71e-2)" "unprognostic (2.28e-2)" "prognostic favorable (4.50e-6)" "unprognostic (1.54e-2)" "unprognostic (3.51e-1)" "unprognostic (1.12e-2)" "unprognostic (1.12e-1)" 32.8 25.2 20.9 24.4 22.6 42.2 29.9 22.1 27.0 22.8 18.1 28.4 20.4 19.7 23.7 25.0 18.5 18.6 21.6 21.7 22.0 32.6 25.1 24.0 30.8 21.1 20.4 19.6 27.7 32.6 14.7 19.5 21.6 20.2 30.9 17.5 26.1 19.7 69.9 23.5 22.5 21.8 21.8 27.6 20.9 28.1 20.7 38.9 31.5 53.5 36.2 22.9 18.7 26.9 32.6 23.4 41.6 39.3 43.6 36.2 41.8 33.7 36.5 48.7 40.4 37.6 33.5 46.5 25.5 45.6 41.3 64.7 56.8 36.7 56.2 42.0 27.3 38.3 33.5 33.6 35.7 67.6 50.8 30.0 49.2 40.1 38.1 37.5 46.2 52.6 45.7 52.2 53.3 48.6 64.0 42.5 38.8 90.4 42.8 51.5 62.7 62.2 42.1 32.3 42.8 42.3 60.3 47.8 41.0 35.0 74.0 42.0 45.3 29.7 28.4 58.4 45.5 57.5 112.4 62.3 40.1 43.5 49.4 61.7 21.8 35.9 22.4 28.6 27.2 26.8 28.2 25.3 24.0 20.2 27.6 26.5 50.9 23.7 33.6 17.2 38.9 25.8 20.9 22.6 22.1 27.0 21.7 22.0 21.1 20.4 21.6 21.8 20.7 26.9 39.8 41.7 37.8 20.5 62.6 77.4 55.5 64.0 60.3 14.0 42.5 28.3 37.9 31.5 43.1 27.6 8.4 45.7 43.7 47.5 56.7 46.3 130.5 22.7 21.5 44.8 47.9 60.2 35.3 55.2 57.5 37.2 34.1 24.7 45.0 20.4 48.5 41.7 52.3 15.2 30.0 43.0 67.1 61.2 60.9 83.3 29.8 51.8 44.4 32.8 60.0 29.2 40.2 22.6 35.8 48.2 37.4 36.1 82.7 47.2 43.7 79.1 34.3 12.5 52.6 28.7 46.1 124.8 48.3 76.8 87.5 87.2 57.1 23.2 43.9 59.8 PPT1 "CLN1, INCL, PPT" ENSG00000131238 "Palmitoyl-protein thioesterase 1" P50897 1 40072710-40097260 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Sensory transduction, Vision" Hydrolase "Disease variant, Neurodegeneration, Neuronal ceroid lipofuscinosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hofbauer cells: 251.9;Kupffer cells: 315.8;Langerhans cells: 328.8;Macrophages: 271.3;monocytes: 227.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 4 "classical monocyte: 1254.3;eosinophil: 624.2;intermediate monocyte: 1006.3;myeloid DC: 1091.1;neutrophil: 683.9;non-classical monocyte: 815.7" "Group enriched" "Detected in all" 4 "dendritic cells: 1091.1;granulocytes: 683.9;monocytes: 1254.3" "Cell line enhanced" "Detected in all" "SK-BR-3: 1082.7;THP-1: 1449.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021546 Supported Supported "Golgi apparatus,Vesicles" "Intracellular and membrane" NA NA 240000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 43: THP-1 - Innate immune response" "Cluster 4: Macrophages - Innate immune response" "Golgi apparatus, Vesicles" "HPA021546: AB_1855667" "unprognostic (5.02e-2)" "unprognostic (2.73e-1)" "unprognostic (1.64e-1)" "unprognostic (2.06e-3)" "unprognostic (6.68e-2)" "unprognostic (2.83e-2)" "prognostic unfavorable (6.98e-8)" "unprognostic (1.39e-1)" "unprognostic (1.78e-1)" "unprognostic (1.23e-1)" "unprognostic (8.16e-2)" "unprognostic (2.39e-1)" "unprognostic (5.20e-3)" "unprognostic (1.75e-1)" "unprognostic (2.30e-1)" "unprognostic (2.93e-2)" "unprognostic (2.08e-2)" 69.8 59.4 92.9 92.7 95.6 117.5 95.7 100.4 135.9 70.1 106.1 50.5 32.1 72.7 60.1 45.1 55.4 57.1 45.3 93.6 101.2 75.8 54.1 128.5 93.9 97.0 96.7 68.6 42.6 79.2 39.0 74.8 99.6 73.4 58.8 89.4 56.8 63.2 21.3 40.3 39.2 95.3 101.6 177.0 45.1 37.6 99.1 78.0 60.0 37.1 75.1 79.1 34.7 113.5 115.6 62.5 93.7 81.0 106.5 92.1 209.8 68.4 127.9 153.0 183.3 350.1 270.5 140.1 118.1 65.2 112.2 209.5 154.9 112.7 163.6 186.4 151.4 100.3 127.2 155.5 137.5 233.7 158.9 103.1 107.5 108.7 126.4 79.7 190.9 108.8 167.7 247.0 80.6 168.1 109.8 88.3 258.3 163.9 93.8 116.0 263.7 226.1 89.2 152.0 114.1 96.9 247.9 1082.7 298.6 111.7 199.3 1449.6 85.2 100.7 147.1 70.7 174.9 161.2 383.8 133.9 109.4 408.7 155.5 85.7 1254.3 624.2 122.2 1006.3 137.9 118.8 171.5 131.3 1091.1 118.6 227.0 168.3 683.9 100.3 815.7 101.8 204.1 1586.9 92.9 95.6 100.4 135.9 93.6 101.2 97.0 96.7 99.6 101.6 99.1 113.5 45.2 28.9 47.7 19.9 33.3 39.6 77.1 30.8 34.7 46.6 55.3 37.5 15.7 41.5 40.0 38.6 16.7 51.7 28.9 4.7 5.9 59.0 64.8 13.8 46.4 49.6 19.9 40.1 28.4 42.1 66.5 56.6 14.8 18.2 84.9 34.6 47.5 9.3 251.9 25.2 39.2 8.1 20.3 315.8 328.8 87.6 31.4 271.3 67.6 31.9 227.2 120.3 28.8 27.6 22.7 22.2 6.0 39.5 34.2 42.4 3.2 18.5 32.3 37.0 19.7 30.5 49.3 17.5 33.0 19.1 27.3 41.2 43.5 39.4 11.4 35.6 PPT2 ENSG00000221988 "Palmitoyl-protein thioesterase 2" Q9UMR5 6 32153441-32163678 "Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Granulosa cells: 33.6;Smooth muscle cells: 27.8;Syncytiotrophoblasts: 23.3" "Cancer enhanced" "Detected in all" "melanoma: 21.5" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "naive CD8 T-cell: 1.0" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "ASC diff: 21.3;HEK 293: 27.9;SK-MEL-30: 29.4" HPA000414 Supported Vesicles "Intracellular and membrane" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 10: Non-specific - Unknown function" Vesicles "HPA000414: " "unprognostic (1.90e-2)" "unprognostic (1.09e-1)" "unprognostic (2.95e-1)" "prognostic unfavorable (5.03e-5)" "unprognostic (1.62e-1)" "unprognostic (6.75e-3)" "unprognostic (2.92e-3)" "unprognostic (6.41e-3)" "unprognostic (7.12e-2)" "unprognostic (2.56e-3)" "unprognostic (5.28e-3)" "unprognostic (1.12e-2)" "unprognostic (2.75e-3)" "unprognostic (5.09e-2)" "unprognostic (2.94e-1)" "unprognostic (4.89e-2)" "unprognostic (1.24e-3)" 19.0 18.0 1.1 2.1 1.1 0.1 18.7 1.1 4.8 26.5 1.0 23.7 1.6 22.0 2.6 28.2 21.7 0.0 24.5 1.1 1.1 22.1 13.9 14.3 1.7 1.1 1.2 46.2 14.3 0.0 13.7 3.9 1.1 17.2 1.5 6.2 14.9 0.0 19.0 29.4 14.9 1.3 1.1 13.3 21.0 8.3 1.1 1.9 14.6 0.2 1.0 18.1 24.2 1.3 0.0 0.0 0.0 0.4 21.3 7.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 16.2 1.6 0.7 5.3 2.6 5.0 0.0 0.0 27.9 4.0 0.0 0.0 0.0 3.5 1.8 4.0 1.6 0.0 7.3 3.8 0.0 14.9 0.0 1.8 1.7 13.0 4.6 0.0 0.0 0.9 0.0 6.3 5.8 0.0 14.3 0.0 1.6 5.4 8.7 5.2 29.4 15.2 0.0 3.7 0.8 0.0 11.4 0.0 0.0 0.8 12.6 3.0 5.8 2.2 3.5 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.2 0.0 0.0 0.0 0.1 1.0 0.0 0.1 0.0 0.7 0.0 0.1 1.1 1.1 1.1 4.8 1.1 1.1 1.1 1.2 1.1 1.1 1.1 1.3 9.4 0.0 0.5 0.0 0.7 3.3 2.9 2.6 5.7 12.4 4.2 2.9 6.8 2.8 2.8 3.7 16.7 14.5 4.4 2.4 1.9 1.8 0.3 4.5 4.3 7.6 4.9 17.4 0.0 3.0 9.2 6.3 1.5 5.0 0.0 33.6 6.4 4.4 3.0 3.3 0.0 2.6 2.0 1.3 1.3 1.1 4.1 1.1 7.2 0.0 0.2 9.5 3.1 0.0 0.0 1.8 3.8 3.0 1.7 1.4 1.4 3.1 0.6 6.1 0.0 3.6 27.8 4.0 6.7 4.4 2.3 23.3 1.4 5.0 3.0 1.5 PPWD1 KIAA0073 ENSG00000113593 "Peptidylprolyl isomerase domain and WD repeat containing 1" Q96BP3 5 65563236-65587549 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "mRNA processing, mRNA splicing" "Isomerase, Rotamase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019353, HPA019360" Enhanced Supported "Nuclear bodies" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 34: Spermatids - Unknown function" "Nuclear bodies" "HPA019353: AB_1855668, HPA019360: AB_1855669" "unprognostic (3.31e-2)" "unprognostic (2.07e-2)" "unprognostic (6.78e-2)" "unprognostic (2.85e-1)" "unprognostic (9.61e-2)" "unprognostic (1.22e-2)" "prognostic unfavorable (2.19e-4)" "unprognostic (1.37e-1)" "unprognostic (4.97e-2)" "unprognostic (1.09e-1)" "unprognostic (7.84e-3)" "unprognostic (5.72e-2)" "prognostic unfavorable (6.72e-4)" "unprognostic (2.40e-1)" "unprognostic (1.18e-1)" "unprognostic (2.15e-1)" "unprognostic (1.30e-2)" 15.0 12.1 12.3 18.2 14.6 27.6 17.2 16.5 16.4 17.3 13.4 14.7 13.4 19.0 17.8 13.5 16.1 15.7 13.5 12.4 13.2 13.0 15.5 14.9 30.0 13.6 12.8 22.9 14.0 15.5 14.7 19.6 13.4 15.0 19.2 14.7 12.7 13.7 13.2 22.2 17.1 13.2 12.9 22.6 14.4 18.1 13.0 32.9 16.3 15.6 26.0 13.7 15.2 18.5 36.5 23.6 35.1 35.2 30.6 36.9 38.8 34.5 25.3 36.5 45.5 37.8 35.4 41.5 28.5 24.3 49.1 32.3 38.4 35.5 49.8 35.7 32.3 26.0 40.0 31.1 25.9 23.9 26.4 29.2 15.3 35.5 25.5 27.0 32.3 31.6 35.3 28.8 28.8 35.8 40.0 31.6 24.7 15.2 13.3 35.4 46.7 35.1 21.2 29.5 18.1 14.8 34.8 14.5 33.1 26.8 21.5 30.8 24.9 20.2 29.2 22.4 52.9 17.1 26.3 45.5 22.3 35.8 21.4 35.0 15.1 31.6 26.1 19.3 32.0 25.8 29.1 29.9 21.2 19.1 36.1 31.0 14.3 26.5 24.0 11.8 38.1 23.4 12.3 14.6 16.5 16.4 12.4 13.2 13.6 12.8 13.4 12.9 13.0 18.5 25.1 28.9 22.4 28.1 36.0 12.4 14.9 15.4 18.2 14.2 9.1 12.8 19.8 7.2 22.1 11.0 8.4 27.7 27.0 6.9 9.8 8.7 76.8 16.4 28.7 20.7 9.6 21.5 37.2 7.7 14.4 21.1 15.8 13.8 11.4 32.6 18.9 6.0 11.8 6.7 46.8 14.9 8.2 16.4 11.9 41.7 20.2 15.2 14.2 23.4 22.6 11.8 23.7 42.3 67.1 8.9 14.7 18.8 29.4 6.6 10.0 7.9 17.8 20.9 6.6 19.9 17.8 32.5 33.7 13.2 11.8 25.2 35.4 15.8 11.4 9.0 PREP ENSG00000085377 "Prolyl endopeptidase" P48147 6 105273218-105454062 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 84.8" "Cell type enhanced" "Detected in many" "Excitatory neurons: 79.7;Syncytiotrophoblasts: 67.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025414, HPA031388, HPA031389, HPA031390" Supported Supported Cytosol NA NA 1700000 "Cluster 27: Non-specific - Gene expression" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 30: Epithelial cell lines - Translation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "CAB025414: , HPA031388: AB_2673855, HPA031389: AB_2673856, HPA031390: AB_2673857" "unprognostic (3.05e-2)" "unprognostic (9.09e-3)" "unprognostic (2.85e-2)" "unprognostic (5.46e-2)" "unprognostic (3.36e-1)" "prognostic unfavorable (3.33e-4)" "unprognostic (2.63e-3)" "unprognostic (2.39e-1)" "unprognostic (6.78e-2)" "unprognostic (5.81e-2)" "unprognostic (2.66e-2)" "unprognostic (1.15e-1)" "unprognostic (4.47e-3)" "unprognostic (2.74e-2)" "unprognostic (8.98e-2)" "unprognostic (6.59e-2)" "unprognostic (2.33e-1)" 17.3 17.4 7.2 14.6 8.1 14.3 17.7 7.4 12.0 15.2 7.8 32.1 23.6 15.8 12.1 21.1 13.0 8.7 22.5 8.8 7.3 11.3 19.0 16.2 13.6 6.7 7.7 16.0 19.2 20.5 13.0 17.8 6.8 11.6 37.5 15.4 18.6 9.0 84.8 33.4 25.6 15.3 6.6 14.3 18.7 21.4 8.8 16.4 12.3 46.9 16.2 21.4 17.5 8.5 22.3 26.9 27.9 32.1 63.1 37.1 27.7 28.6 27.0 37.2 39.0 35.9 14.2 28.5 26.8 33.9 35.0 33.3 41.8 86.5 42.7 41.8 37.4 38.1 21.7 40.0 25.3 40.5 26.2 35.8 53.4 27.6 71.7 28.0 35.4 50.1 67.4 49.8 45.5 38.8 25.8 41.4 27.9 44.2 25.0 41.1 48.4 18.3 28.2 53.8 36.0 51.8 25.3 42.0 21.7 35.3 17.9 61.9 36.1 17.3 23.9 21.6 36.2 14.2 9.7 38.5 30.4 42.6 56.6 5.5 15.2 8.4 16.3 16.8 16.8 9.3 14.2 17.1 16.5 6.9 12.9 15.5 0.8 19.9 22.7 7.0 13.6 13.5 7.2 8.1 7.4 12.0 8.8 7.3 6.7 7.7 6.8 6.6 8.8 8.5 6.3 3.2 6.7 22.9 10.1 10.8 6.8 12.0 5.7 5.1 6.0 5.5 14.8 7.2 13.6 7.3 14.6 28.2 14.5 19.3 5.9 10.4 1.4 6.6 15.1 10.1 19.3 11.2 79.7 11.7 35.9 10.6 24.5 11.6 13.4 11.2 7.5 15.1 15.0 13.5 48.3 29.4 10.2 14.2 10.8 3.2 10.8 13.3 5.4 27.2 19.1 3.3 5.2 28.6 18.7 18.0 29.1 9.1 11.0 5.3 18.5 8.8 4.8 10.4 0.0 8.3 10.3 3.9 18.8 12.9 8.5 67.9 16.1 14.4 38.2 8.5 PRKAA1 AMPKa1 ENSG00000132356 "Protein kinase AMP-activated catalytic subunit alpha 1" Q13131 5 40759379-40798374 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Autophagy, Biological rhythms, Cholesterol biosynthesis, Cholesterol metabolism, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism, Transcription, Transcription regulation, Wnt signaling pathway" "Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 4 "Early spermatids: 292.5;Late spermatids: 478.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005050, HPA035409, HPA064946" Supported Supported "Nuclear speckles,Cytosol" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 34: Non-specific - Transcription" "Cluster 20: HeLa - Mitochondria" "Cluster 31: Spermatids - Spermatogenesis" "Nuclear speckles" Cytosol "CAB005050: AB_562037, HPA035409: AB_2674613, HPA064946: AB_2685390" "unprognostic (2.07e-1)" "unprognostic (1.41e-2)" "unprognostic (2.51e-2)" "unprognostic (3.57e-2)" "unprognostic (3.97e-1)" "unprognostic (1.05e-1)" "unprognostic (3.51e-2)" "unprognostic (7.53e-2)" "unprognostic (1.66e-2)" "unprognostic (2.88e-1)" "unprognostic (3.34e-3)" "unprognostic (2.63e-1)" "unprognostic (2.82e-2)" "unprognostic (1.35e-1)" "unprognostic (1.60e-1)" "unprognostic (1.27e-2)" "unprognostic (1.10e-2)" 33.3 21.0 7.9 27.2 9.6 52.6 30.2 10.3 11.0 26.7 12.3 30.0 35.4 26.3 18.6 20.6 21.0 33.5 20.2 6.9 11.3 32.0 49.9 27.4 29.2 11.8 9.9 19.1 23.1 32.0 9.2 21.2 12.2 31.9 34.7 19.0 27.4 24.7 16.9 23.1 30.9 26.4 10.2 27.8 33.7 41.1 10.0 21.8 32.3 19.9 23.9 28.8 17.8 10.3 28.4 28.9 22.8 30.2 55.0 57.0 21.6 47.3 48.1 34.7 30.8 27.6 35.9 16.6 21.4 48.8 45.3 22.4 21.3 43.1 64.9 49.2 19.2 33.1 66.1 22.1 45.3 31.9 33.5 52.8 20.6 46.5 47.5 38.4 52.1 21.0 15.9 46.7 52.4 13.6 29.7 24.9 9.9 28.9 34.6 24.5 48.7 24.6 53.3 47.5 19.6 19.7 83.0 54.3 28.8 12.3 28.4 26.0 56.0 62.1 33.5 36.2 39.2 18.5 15.4 19.6 38.9 67.9 33.9 17.0 6.5 12.8 8.9 7.9 11.5 8.2 8.4 8.6 6.4 7.9 10.1 9.0 15.4 10.9 9.3 1.9 11.6 6.5 7.9 9.6 10.3 11.0 6.9 11.3 11.8 9.9 12.2 10.2 10.0 10.3 47.3 41.7 26.5 19.2 34.1 24.1 24.7 40.5 15.4 20.3 36.1 17.9 18.3 42.9 43.4 47.8 35.5 13.8 45.8 44.1 7.9 27.9 292.5 19.7 35.8 42.4 21.1 25.4 24.5 44.9 13.7 36.2 36.7 20.7 18.3 17.8 37.1 83.4 20.0 15.2 30.3 28.8 42.7 25.3 28.5 478.5 30.4 24.1 35.6 24.4 40.9 15.4 44.3 30.7 43.8 36.0 32.8 25.9 23.4 33.4 33.7 35.4 42.9 27.9 0.0 22.7 43.1 82.8 17.6 19.9 32.7 18.6 44.0 19.2 36.9 35.0 PRKAA2 "AMPK, AMPKa2, PRKAA" ENSG00000162409 "Protein kinase AMP-activated catalytic subunit alpha 2" P54646 1 56645314-56715335 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted membrane proteins, Transporters" "Autophagy, Biological rhythms, Cholesterol biosynthesis, Cholesterol metabolism, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism, Transcription, Transcription regulation, Wnt signaling pathway" "Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 40.8;skeletal muscle: 38.7;tongue: 36.4" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 328.5;Excitatory neurons: 109.4;Inhibitory neurons: 119.0;Oligodendrocyte precursor cells: 84.9;Rod photoreceptor cells: 115.5" "Cancer enhanced" "Detected in many" "renal cancer: 5.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "RPTEC TERT1: 14.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044540 Approved Supported "Nuclear speckles,Golgi apparatus" NA NA "Cluster 38: Heart - Muscle contraction" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 54: Cardiomyocytes - Muscle contraction" "Nuclear speckles" "Golgi apparatus" "HPA044540: AB_2678977" "unprognostic (4.17e-3)" "unprognostic (1.62e-2)" "unprognostic (4.17e-1)" "prognostic unfavorable (4.80e-4)" "unprognostic (9.35e-2)" "unprognostic (1.92e-3)" "prognostic unfavorable (5.30e-4)" "unprognostic (7.30e-2)" "unprognostic (3.94e-1)" "unprognostic (1.82e-1)" "unprognostic (1.97e-1)" "unprognostic (8.64e-2)" "prognostic favorable (4.95e-5)" "unprognostic (1.30e-2)" "unprognostic (4.52e-2)" "unprognostic (1.57e-2)" "unprognostic (1.85e-1)" 1.4 1.4 2.0 0.5 3.5 0.0 3.3 3.0 3.5 1.4 4.1 5.0 0.5 1.8 1.1 4.7 2.7 1.9 40.8 3.9 2.1 13.6 0.7 1.4 0.1 0.9 1.3 1.5 1.8 8.3 1.3 0.5 0.9 3.8 1.4 13.5 4.3 2.6 38.7 0.7 1.3 3.1 0.3 1.3 2.2 1.1 1.3 0.4 3.3 36.4 0.1 1.8 1.3 1.5 0.0 3.8 2.1 0.0 0.7 0.5 2.3 1.9 1.5 2.5 4.3 3.9 4.9 0.0 0.6 0.6 7.5 0.1 8.0 0.0 7.1 0.0 8.8 0.0 7.0 5.5 0.0 0.0 0.1 0.6 0.0 3.5 0.3 5.8 0.8 2.0 0.0 0.0 1.1 0.1 0.0 0.0 5.6 0.0 5.5 0.0 0.0 0.0 14.1 1.3 2.0 5.5 6.0 0.1 0.0 6.0 3.3 0.0 0.0 1.5 2.3 2.8 6.6 0.0 0.0 0.0 4.5 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 3.5 3.0 3.5 3.9 2.1 0.9 1.3 0.9 0.3 1.3 1.5 1.1 9.6 4.8 30.7 2.0 0.9 8.0 6.7 2.2 42.0 19.4 9.5 328.5 24.3 14.3 49.7 50.1 1.0 0.2 6.1 54.8 9.5 3.9 14.4 2.9 10.3 14.4 0.0 109.4 4.8 0.4 15.3 5.1 17.4 2.5 11.7 9.7 8.1 0.1 26.9 119.0 6.3 8.2 0.0 1.6 4.8 6.8 1.4 5.4 18.7 0.0 18.6 0.0 84.9 20.4 6.2 3.0 29.3 0.0 21.2 0.2 82.4 10.7 115.5 6.6 24.5 17.2 7.2 3.7 17.7 0.4 0.4 1.2 5.3 6.1 13.4 PRKAB2 ENSG00000131791 "Protein kinase AMP-activated non-catalytic subunit beta 2" O43741 1 147155106-147172550 "FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 97.2;tongue: 103.8" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 66.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044342 Enhanced Approved Nucleoplasm,Cytosol NA NA "Cluster 15: NK-cells - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 45: Enterocytes - Digestion" Nucleoplasm Cytosol "HPA044342: AB_10966508" "prognostic unfavorable (4.55e-4)" "unprognostic (2.03e-2)" "unprognostic (1.84e-1)" "unprognostic (4.03e-2)" "unprognostic (9.59e-3)" "prognostic unfavorable (7.32e-4)" "unprognostic (6.30e-2)" "unprognostic (1.23e-1)" "unprognostic (3.06e-2)" "unprognostic (6.78e-2)" "unprognostic (4.65e-2)" "unprognostic (1.98e-1)" "unprognostic (5.34e-2)" "unprognostic (1.31e-1)" "unprognostic (3.57e-1)" "prognostic unfavorable (6.78e-7)" "unprognostic (4.78e-2)" 12.4 10.8 9.4 7.8 10.1 9.0 11.8 12.5 13.1 14.8 6.0 23.4 32.0 18.7 8.5 10.3 12.9 7.1 25.8 10.1 9.5 9.5 56.3 10.0 6.5 10.8 10.1 11.7 34.8 64.7 6.7 12.3 11.0 12.7 10.7 14.7 8.2 19.4 97.2 15.4 20.8 19.8 10.8 8.5 18.1 6.7 10.6 5.9 6.3 103.8 5.6 18.6 14.0 11.2 7.8 4.2 11.1 8.6 25.7 22.1 39.7 14.3 7.9 9.5 10.3 17.1 15.1 13.9 7.1 11.6 5.5 20.2 13.1 16.1 9.2 5.5 9.0 6.2 15.2 27.8 17.7 7.4 2.6 17.4 31.7 9.9 46.0 14.1 9.4 10.6 8.9 5.6 8.2 7.8 5.5 4.1 23.3 13.4 18.4 8.5 14.8 6.9 6.8 6.1 7.1 13.2 10.8 12.1 52.8 39.6 11.4 9.1 10.8 10.6 23.3 9.9 23.6 8.9 10.1 7.1 11.0 6.4 14.1 0.9 0.3 0.6 0.4 0.4 0.7 0.3 0.4 0.3 0.5 0.3 0.5 0.3 0.1 1.5 0.5 0.2 0.2 0.2 9.4 10.1 12.5 13.1 10.1 9.5 10.8 10.1 11.0 10.8 10.6 11.2 10.4 3.2 2.0 14.0 10.6 16.6 11.8 11.4 18.2 14.5 6.7 8.1 66.2 20.0 5.3 18.4 14.6 21.9 10.3 22.7 1.9 6.1 0.8 5.4 15.1 8.2 11.4 3.4 23.2 7.0 42.1 13.6 13.7 10.4 1.3 11.8 6.8 44.9 5.7 11.8 18.8 12.6 10.2 8.9 12.5 1.8 9.6 7.3 16.0 10.3 12.2 6.4 11.3 25.1 21.3 9.9 12.0 16.1 9.0 7.2 55.1 5.4 7.0 19.5 19.7 11.3 20.4 13.9 11.2 13.1 14.1 20.5 9.7 43.4 10.1 4.8 PRKACA PKACa ENSG00000072062 "Protein kinase cAMP-activated catalytic subunit alpha" P17612 19 14091688-14118084 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Cushing syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 310.9" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 116.8;Theca cells: 100.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010361, HPA071185" Approved Approved "Cytokinetic bridge,Cytosol" Yes NA 170000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 39: Non-specific - Mitochondria" "Cluster 18: U-2197 - ECM organization" "Cluster 52: Non-specific - Transcription" Cytosol "Cytokinetic bridge" "CAB010361: AB_2268772, HPA071185: AB_2686356" "unprognostic (1.08e-1)" "prognostic favorable (6.28e-6)" "unprognostic (2.09e-2)" "prognostic unfavorable (6.26e-5)" "unprognostic (1.38e-2)" "unprognostic (2.95e-1)" "unprognostic (1.64e-1)" "unprognostic (9.36e-3)" "unprognostic (7.01e-2)" "unprognostic (3.41e-1)" "prognostic favorable (6.47e-4)" "unprognostic (2.86e-1)" "unprognostic (1.17e-1)" "unprognostic (4.68e-2)" "unprognostic (1.87e-1)" "unprognostic (3.66e-2)" "unprognostic (6.14e-3)" 62.7 126.5 46.6 27.6 47.6 18.9 53.9 39.9 64.2 53.2 29.5 59.0 20.9 56.9 28.5 41.8 53.7 14.2 204.8 49.2 53.3 35.4 78.4 46.1 15.9 56.8 54.5 94.1 34.0 21.6 71.2 17.3 55.3 41.2 13.0 25.2 42.3 20.8 310.9 42.3 36.3 21.8 40.7 71.6 40.2 57.2 50.3 18.2 39.6 122.1 13.4 50.6 44.2 46.6 37.5 16.3 40.3 74.4 36.2 30.8 9.9 30.5 23.6 32.7 27.5 21.6 15.0 13.8 26.2 49.2 22.9 25.4 26.7 26.6 32.3 23.1 17.7 27.7 20.6 24.4 36.8 21.9 33.5 33.8 18.1 30.0 11.1 26.6 29.7 19.0 29.1 47.3 36.7 48.1 46.3 31.9 21.5 38.7 45.0 38.0 47.8 36.7 41.7 13.5 36.5 24.2 34.2 31.3 23.8 18.1 37.2 26.5 37.7 71.7 20.3 100.7 39.6 31.9 24.9 23.6 49.6 28.0 32.7 0.1 1.5 0.2 0.8 2.7 0.3 0.8 0.3 0.5 1.1 0.5 0.5 0.7 3.2 0.4 2.5 0.6 0.3 0.6 46.6 47.6 39.9 64.2 49.2 53.3 56.8 54.5 55.3 40.7 50.3 46.6 39.5 6.4 3.4 9.4 7.0 8.8 6.8 6.4 2.2 42.2 19.2 19.0 116.8 22.8 4.7 14.7 27.1 6.9 9.0 24.6 7.9 12.4 32.4 11.7 22.9 26.7 17.5 2.5 16.9 19.1 5.7 22.6 8.6 12.9 0.0 15.9 26.4 39.7 34.5 3.3 21.6 11.8 2.0 49.4 50.8 15.7 49.0 37.1 14.2 9.4 37.8 26.1 9.2 10.1 10.7 15.6 11.6 51.9 3.3 6.4 20.7 11.8 7.0 23.9 19.7 23.3 23.5 26.4 6.9 10.1 11.2 8.1 10.0 100.6 14.4 6.6 PRKACB PKACb ENSG00000142875 "Protein kinase cAMP-activated catalytic subunit beta" P22694 1 84078062-84238498 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 334.4;Inhibitory neurons: 348.8;Oligodendrocyte precursor cells: 302.6;Oligodendrocytes: 499.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010363, HPA029754, HPA071185" Approved Approved "Cytokinetic bridge,Cytosol" Yes NA 130000 "Cluster 48: NK-cells - Unknown function" "Cluster 6: Brain - Smell perception" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "Cytokinetic bridge" "CAB010363: AB_2170182, HPA029754: AB_10601491, HPA071185: AB_2686356" "unprognostic (9.38e-2)" "unprognostic (1.18e-1)" "unprognostic (6.37e-2)" "unprognostic (1.39e-1)" "unprognostic (1.58e-1)" "unprognostic (1.98e-1)" "prognostic unfavorable (9.49e-4)" "unprognostic (1.28e-1)" "unprognostic (3.28e-2)" "unprognostic (1.92e-1)" "unprognostic (2.31e-1)" "unprognostic (4.62e-2)" "prognostic favorable (1.89e-6)" "unprognostic (1.22e-1)" "unprognostic (3.28e-1)" "unprognostic (1.12e-2)" "unprognostic (2.48e-1)" 16.5 47.7 79.4 26.1 101.6 16.0 17.7 70.0 113.3 19.8 0.0 55.9 10.8 19.2 38.8 17.8 10.0 26.2 23.8 100.7 107.5 23.8 20.8 15.8 41.8 53.5 44.4 17.8 27.8 23.5 24.7 11.5 65.4 30.6 51.7 71.6 83.7 27.3 4.9 4.1 12.7 28.8 59.9 36.0 34.1 8.1 91.0 63.5 25.2 13.5 36.8 27.6 7.7 110.0 8.6 16.9 26.4 31.8 29.9 26.1 12.3 41.7 31.4 20.8 19.4 0.4 7.5 45.1 28.0 32.8 38.0 5.8 12.6 13.6 22.0 44.1 6.8 99.3 21.3 3.2 29.4 39.8 2.2 15.6 6.0 20.2 11.2 30.2 97.2 16.7 3.2 25.2 34.3 1.6 51.8 21.0 26.1 0.1 11.8 39.6 41.2 27.3 50.5 30.2 8.6 33.4 23.0 8.8 25.6 19.7 8.1 8.2 86.8 28.7 22.4 29.4 31.9 18.6 24.2 45.3 13.7 41.5 36.5 56.3 7.5 16.4 59.3 10.2 47.7 35.2 43.4 52.9 19.4 28.4 65.0 69.5 3.8 73.1 16.2 11.1 44.2 66.8 79.4 101.6 70.0 113.3 100.7 107.5 53.5 44.4 65.4 59.9 91.0 110.0 9.5 0.0 1.5 118.8 56.6 5.1 7.2 3.5 11.4 44.9 11.5 9.1 44.4 21.5 5.2 14.7 35.5 1.9 103.0 115.5 33.2 6.2 2.9 11.4 27.0 13.4 21.7 52.3 334.4 11.9 1.2 17.0 16.3 14.0 58.9 15.2 28.5 17.0 27.1 47.1 348.8 58.1 4.1 62.3 24.4 3.6 14.9 51.6 16.0 95.5 14.6 35.6 96.8 302.6 499.0 20.6 42.2 21.8 53.9 10.0 4.5 25.6 6.3 34.4 13.1 14.1 20.3 13.9 8.0 8.1 2.8 0.7 87.6 11.4 51.1 9.1 PRKACG PKACg ENSG00000165059 "Protein kinase cAMP-activated catalytic subunit gamma" P22612 9 69012504-69014113 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 152 "testis: 24.6" "Group enriched" "Detected in some" 27 "Early spermatids: 71.0;Late spermatids: 88.4;Spermatocytes: 41.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "CAB004530, HPA071185" Supported Uncertain "Cytokinetic bridge,Cytosol" Yes NA "Cluster 74: Testis - Spermatogenesis" "Cluster 66: Spermatocytes - Spermatogenesis" Cytosol "Cytokinetic bridge" "CAB004530: AB_628137, HPA071185: AB_2686356" "unprognostic (2.74e-1)" "unprognostic (3.61e-2)" "unprognostic (7.22e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 24.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 71.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 88.4 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 41.3 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 PRKAG2 "AAKG, AAKG2, CMH6, H91620p, WPWS" ENSG00000106617 "Protein kinase AMP-activated non-catalytic subunit gamma 2" Q9UGJ0 7 151556124-151877125 "Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" "Cardiomyopathy, Disease variant, FDA approved drug targets, Glycogen storage disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 143.0" "Cell type enhanced" "Detected in all" "Excitatory neurons: 208.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "GAMG: 178.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004246, CAB018641" Uncertain Approved Nucleoplasm NA NA "Cluster 34: Basophils - Unknown function" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "CAB018641: AB_2170355, HPA004246: AB_1078151" "unprognostic (4.11e-2)" "unprognostic (2.82e-1)" "unprognostic (1.46e-2)" "unprognostic (9.29e-2)" "unprognostic (1.76e-1)" "unprognostic (4.33e-3)" "unprognostic (7.13e-2)" "unprognostic (8.09e-2)" "unprognostic (1.77e-1)" "unprognostic (1.18e-1)" "unprognostic (2.46e-2)" "unprognostic (1.42e-1)" "unprognostic (1.35e-1)" "unprognostic (1.67e-1)" "unprognostic (3.80e-1)" "unprognostic (3.61e-2)" "unprognostic (4.52e-1)" 27.1 7.7 21.7 12.8 20.3 8.1 18.4 16.7 22.8 16.2 11.1 25.8 24.4 19.8 14.3 16.2 17.9 12.8 143.0 23.7 21.1 22.5 36.1 14.2 11.6 19.3 17.4 10.9 10.9 9.2 9.5 16.1 19.7 25.3 18.9 2.9 15.0 19.5 15.0 13.5 26.2 16.5 15.8 17.6 26.7 12.8 18.5 7.9 16.6 21.7 9.8 47.9 17.5 19.6 46.6 13.6 9.1 10.6 36.4 28.6 14.4 21.5 19.5 22.7 22.3 8.6 52.5 0.0 34.0 28.9 178.2 13.9 5.7 22.4 30.0 15.8 6.2 11.5 1.8 0.9 60.8 8.5 11.4 16.5 49.7 21.8 21.0 34.1 40.2 14.9 4.1 5.6 66.2 17.2 3.5 6.7 9.7 18.8 37.5 5.6 6.9 9.7 39.2 10.9 38.5 6.7 10.7 19.9 10.0 22.9 4.0 13.6 52.8 5.0 4.3 2.8 13.1 3.5 5.1 0.0 63.5 29.8 45.9 26.2 9.3 10.9 5.3 7.0 4.1 9.6 4.9 4.8 6.5 4.0 4.8 7.3 11.1 4.4 6.4 6.0 2.9 5.3 21.7 20.3 16.7 22.8 23.7 21.1 19.3 17.4 19.7 15.8 18.5 19.6 19.2 6.4 19.8 37.5 24.8 10.6 39.9 25.0 19.9 22.3 20.6 14.5 122.3 8.6 22.9 46.0 8.4 3.9 43.8 29.5 64.6 14.1 49.3 75.1 16.9 20.4 13.1 3.8 208.5 22.7 31.2 24.9 21.9 98.1 22.2 4.6 18.9 76.8 17.7 3.3 85.2 34.5 105.8 57.2 48.2 35.8 7.5 50.9 16.0 73.1 62.9 14.7 37.0 39.2 4.4 27.5 21.9 7.9 23.4 45.7 77.7 19.7 14.2 6.1 13.1 6.9 27.3 4.0 32.3 12.8 10.9 50.6 27.3 5.0 28.0 45.2 PRKAR1A "CNC1, PRKAR1, TSE1" ENSG00000108946 "Protein kinase cAMP-dependent type I regulatory subunit alpha" P10644 17 68511780-68551319 "Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cancer-related genes, Cushing syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 606.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB019378, HPA049979" Approved Approved Cytosol NA NA 1800000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 54: Cardiomyocytes - Muscle contraction" Cytosol "CAB019378: , HPA049979: AB_2680980" "unprognostic (8.69e-2)" "unprognostic (6.97e-2)" "unprognostic (5.34e-2)" "unprognostic (2.04e-1)" "unprognostic (1.68e-1)" "unprognostic (4.39e-2)" "unprognostic (2.61e-1)" "unprognostic (6.42e-2)" "unprognostic (2.27e-1)" "unprognostic (2.30e-1)" "unprognostic (1.19e-2)" "unprognostic (5.55e-2)" "unprognostic (8.56e-3)" "unprognostic (6.26e-2)" "unprognostic (6.92e-2)" "unprognostic (3.29e-2)" "unprognostic (1.11e-1)" 125.9 158.2 72.0 124.1 83.2 57.1 118.4 76.7 119.1 151.2 97.3 70.0 51.7 145.5 122.3 98.5 141.3 125.2 430.0 89.0 102.1 164.3 150.8 163.7 111.4 85.6 91.8 202.8 63.1 300.2 88.0 164.3 105.0 114.5 79.1 132.2 169.7 137.6 250.6 63.8 58.7 132.1 71.7 121.7 86.9 130.8 91.8 109.4 173.6 147.4 103.6 136.4 67.6 93.5 95.5 180.0 225.9 136.1 294.6 331.7 33.9 125.7 257.9 192.2 168.6 70.5 125.5 96.3 84.3 276.7 196.8 77.2 168.8 204.2 273.8 65.8 60.4 149.1 154.0 233.0 213.0 115.8 160.2 239.1 207.4 222.3 185.9 215.0 324.6 80.8 68.5 147.2 236.4 181.0 128.2 60.9 83.9 97.7 121.4 88.1 373.6 106.7 292.4 204.3 81.8 110.3 115.4 207.6 496.8 208.5 162.8 161.1 232.2 269.4 127.6 123.3 119.0 121.6 93.5 142.4 163.0 107.8 171.8 149.6 108.3 189.4 48.6 101.0 48.8 42.8 35.9 43.6 105.9 32.3 32.1 35.9 208.2 76.1 120.9 34.7 50.9 113.5 72.0 83.2 76.7 119.1 89.0 102.1 85.6 91.8 105.0 71.7 91.8 93.5 134.1 147.4 263.4 38.5 126.0 142.8 100.1 136.8 116.7 99.6 106.8 65.4 606.2 81.5 156.4 252.0 66.7 77.4 127.4 58.1 178.1 80.7 407.9 142.9 116.4 131.8 136.9 52.5 76.1 52.0 86.8 163.2 78.5 110.3 185.0 78.2 158.1 120.7 146.1 139.7 78.4 53.3 136.3 176.2 171.1 93.7 133.6 151.1 192.1 46.9 142.3 125.1 78.2 57.3 76.3 74.6 51.5 190.7 95.6 85.3 27.1 210.1 307.7 59.9 85.5 123.2 210.9 219.8 54.2 122.4 131.7 82.5 117.3 184.0 43.9 112.8 PRKAR1B ENSG00000188191 "Protein kinase cAMP-dependent type I regulatory subunit beta" P31321 7 549197-727650 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "brain: 175.7" "Cell type enhanced" "Detected in many" "Early spermatids: 62.3;Excitatory neurons: 78.7;Inhibitory neurons: 61.1;Late spermatids: 130.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "NTERA-2: 128.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026719 Approved NA NA "Cluster 24: B-cells - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 25: Spermatids - Spermatogenesis" "HPA026719: AB_1855419" "unprognostic (4.90e-2)" "unprognostic (4.92e-2)" "unprognostic (2.69e-1)" "unprognostic (4.34e-2)" "unprognostic (1.74e-3)" "unprognostic (1.02e-3)" "unprognostic (3.28e-2)" "unprognostic (4.24e-2)" "unprognostic (1.73e-1)" "unprognostic (1.41e-2)" "unprognostic (2.01e-3)" "unprognostic (1.95e-1)" "unprognostic (3.38e-3)" "unprognostic (5.18e-2)" "unprognostic (2.64e-1)" "unprognostic (9.23e-2)" "unprognostic (2.00e-1)" 12.0 11.0 79.6 7.5 99.4 8.8 12.4 0.0 175.7 17.6 0.0 19.4 12.3 23.5 3.7 12.0 15.8 7.6 17.1 105.2 76.3 15.9 12.9 12.4 9.7 62.9 15.9 28.1 6.5 8.9 35.7 5.5 53.3 12.6 6.5 19.3 7.3 8.3 7.3 8.0 13.4 8.7 4.2 22.8 11.3 15.4 52.5 10.2 8.2 3.8 5.3 10.2 13.5 88.9 83.0 54.2 8.0 19.7 5.1 4.6 22.8 15.9 7.3 10.0 5.7 97.9 17.5 63.2 11.3 7.2 33.1 60.3 27.0 30.6 4.2 12.8 20.1 4.3 33.3 65.4 9.7 39.7 9.5 12.8 9.2 6.8 18.7 11.1 10.8 15.7 61.6 11.8 9.2 77.8 47.5 26.5 128.0 22.1 23.0 30.9 1.6 27.4 25.0 20.8 106.0 81.5 41.2 39.2 32.0 3.2 20.1 14.6 13.0 4.4 9.9 6.0 32.3 7.7 23.4 41.0 8.2 29.8 59.5 1.8 2.4 0.0 5.0 3.0 7.7 7.4 8.9 7.7 2.8 10.0 13.8 13.3 0.9 4.6 1.2 6.6 6.6 10.5 79.6 99.4 0.0 175.7 105.2 76.3 62.9 15.9 53.3 4.2 52.5 88.9 18.3 3.2 4.4 12.4 7.3 3.8 7.4 6.0 6.2 11.1 9.0 12.8 13.1 4.3 5.0 5.5 4.2 4.0 7.0 10.1 25.4 4.1 62.3 4.5 6.5 15.2 4.2 13.5 78.7 3.4 5.8 8.2 10.7 4.4 7.0 55.0 16.4 8.5 8.9 53.8 61.1 10.9 2.0 6.2 8.6 130.0 11.8 8.7 7.2 15.0 1.6 7.3 5.2 24.1 7.5 7.7 14.1 15.4 8.2 5.6 20.7 24.5 1.4 6.3 0.0 12.8 9.0 15.6 11.1 10.7 4.7 3.4 9.1 12.0 15.5 5.0 PRKAR2A PRKAR2 ENSG00000114302 "Protein kinase cAMP-dependent type II regulatory subunit alpha" P13861 3 48744597-48847874 "Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 82.7;testis: 82.5" "Group enriched" "Detected in all" 8 "Early spermatids: 788.7;Late spermatids: 1370.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005023, HPA038268" Uncertain NA NA 210000 "Cluster 14: Monocytes - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 16: U-266 - Nucleosome" "Cluster 34: Spermatids - Unknown function" "CAB005023: AB_562330, HPA038268: AB_2675921" "unprognostic (2.81e-2)" "unprognostic (3.59e-1)" "prognostic favorable (4.27e-5)" "unprognostic (1.60e-1)" "unprognostic (4.01e-2)" "unprognostic (6.17e-3)" "prognostic unfavorable (1.97e-4)" "unprognostic (4.77e-2)" "unprognostic (2.65e-1)" "unprognostic (1.47e-1)" "unprognostic (1.13e-1)" "unprognostic (9.18e-2)" "prognostic favorable (2.07e-4)" "unprognostic (3.59e-2)" "unprognostic (3.54e-1)" "unprognostic (1.46e-3)" "unprognostic (1.08e-2)" 19.0 14.8 8.3 11.6 7.4 18.5 13.0 8.1 9.1 10.4 11.7 23.5 12.9 9.9 9.3 18.5 17.6 8.3 17.2 7.9 14.3 18.1 15.8 12.5 8.9 12.4 10.1 10.7 12.5 16.5 6.8 11.4 11.7 14.3 19.6 15.8 17.1 14.4 82.7 13.8 13.9 16.2 11.8 9.3 14.2 82.5 10.8 4.9 17.2 39.4 12.5 11.8 10.0 12.0 39.2 25.9 21.2 16.4 31.1 31.4 23.8 44.0 21.8 37.7 23.7 34.4 17.1 34.3 30.1 45.7 24.4 17.6 61.0 38.4 50.4 28.3 22.6 45.8 44.7 25.4 22.8 48.6 28.3 26.2 29.5 48.5 35.4 14.1 40.2 11.5 52.3 21.4 35.9 15.2 0.4 15.7 15.1 28.6 28.4 14.7 26.9 43.6 24.2 42.4 21.0 21.6 43.2 50.8 29.1 22.8 34.2 37.1 51.5 33.0 26.3 54.2 61.0 36.2 76.4 32.5 44.5 52.5 25.4 8.0 6.5 8.0 6.7 6.1 6.6 6.0 5.8 5.8 6.3 5.0 3.9 4.0 9.2 7.0 12.0 3.9 5.5 5.2 8.3 7.4 8.1 9.1 7.9 14.3 12.4 10.1 11.7 11.8 10.8 12.0 61.5 19.2 62.2 42.1 36.5 41.9 25.5 26.9 48.9 44.2 51.0 34.9 70.8 50.1 33.1 46.0 68.8 25.0 61.2 92.3 21.5 41.3 788.7 64.2 60.4 48.8 42.0 22.9 62.4 60.3 34.6 37.6 43.8 41.3 13.3 29.4 55.0 121.4 48.8 62.2 73.1 42.5 34.6 52.2 45.3 1370.7 55.0 48.0 30.2 38.4 48.3 24.8 39.1 42.7 90.9 66.4 46.9 55.7 48.6 34.0 45.2 41.2 50.3 46.2 52.6 51.8 46.6 82.1 61.0 79.0 62.8 23.5 54.1 32.8 87.9 26.6 PRKAR2B PRKAR2 ENSG00000005249 "Protein kinase cAMP-dependent type II regulatory subunit beta" P31323 7 107044705-107161811 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adipose tissue: 135.8" "Cell type enhanced" "Detected in many" "Erythroid cells: 110.2;Excitatory neurons: 146.3;Granulosa cells: 712.1;Theca cells: 271.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AN3-CA: 70.7;Daudi: 99.8;K-562: 61.4;U-698: 254.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008421, HPA063879" Enhanced Uncertain Mitochondria NA NA 570000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 40: Granulosa cells - Unknown function" Mitochondria "HPA008421: AB_1855421, HPA063879: " "unprognostic (3.18e-1)" "unprognostic (2.48e-2)" "prognostic favorable (6.38e-4)" "unprognostic (1.63e-2)" "unprognostic (3.33e-3)" "unprognostic (2.43e-3)" "unprognostic (2.76e-1)" "unprognostic (8.14e-3)" "unprognostic (1.70e-1)" "unprognostic (5.97e-2)" "prognostic favorable (4.03e-4)" "unprognostic (1.50e-1)" "unprognostic (5.12e-3)" "unprognostic (2.39e-1)" "unprognostic (1.11e-1)" "prognostic unfavorable (8.74e-4)" "unprognostic (7.15e-2)" 135.8 44.9 10.7 4.8 12.1 14.2 51.3 5.7 17.5 8.0 5.3 11.1 3.6 6.9 4.4 11.2 7.0 4.9 15.5 13.2 9.5 8.8 2.5 7.6 3.8 6.2 10.2 26.4 8.7 6.5 11.4 15.1 8.3 9.2 6.9 7.5 9.9 4.4 1.5 3.7 11.5 5.1 6.9 16.7 9.1 13.6 7.8 2.6 3.5 6.1 4.0 20.3 6.2 10.1 0.1 1.5 9.1 70.7 36.8 0.0 0.1 3.6 11.5 3.0 2.7 0.0 0.2 99.8 0.8 2.3 8.6 0.1 7.1 0.0 5.5 2.8 7.9 33.3 0.1 0.0 10.3 0.6 4.5 0.5 0.0 0.3 0.0 3.1 42.9 5.4 61.4 2.9 0.1 7.5 14.0 0.4 17.3 0.0 2.8 4.0 0.2 0.0 0.1 0.1 11.6 16.7 5.4 1.2 3.9 22.9 2.1 7.0 24.4 3.5 9.2 0.0 7.1 2.1 0.1 254.8 2.5 17.5 33.9 0.6 0.4 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.2 0.1 0.2 0.3 0.0 0.6 10.7 12.1 5.7 17.5 13.2 9.5 6.2 10.2 8.3 6.9 7.8 10.1 39.6 3.2 1.5 9.8 1.9 2.4 1.6 2.1 0.6 33.5 27.9 10.5 35.9 12.8 5.1 7.3 10.4 0.1 3.7 1.7 0.0 2.5 7.9 1.8 16.2 17.4 0.0 110.2 146.3 0.0 0.6 17.5 3.6 0.9 4.5 712.1 19.2 0.0 1.6 5.0 71.9 1.9 4.1 19.6 26.4 8.5 29.8 64.1 17.8 15.9 17.0 6.4 3.1 60.8 10.9 0.1 2.1 53.0 2.0 3.5 0.0 0.8 5.4 11.9 19.7 5.4 57.7 2.5 6.5 0.7 2.4 0.0 3.7 271.7 2.7 4.6 PRKCA "PKCA, PKCα" ENSG00000154229 "Protein kinase C alpha" P17252 17 66302613-66810743 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" "Angiogenesis, Apoptosis, Cell adhesion" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 76.8" "Cell type enhanced" "Detected in many" "Astrocytes: 564.8;Excitatory neurons: 247.6;Inhibitory neurons: 400.0;Microglial cells: 281.1;Oligodendrocyte precursor cells: 849.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "U-87 MG: 157.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003844, HPA006563, HPA006564, CAB016290" Enhanced Approved Enhanced "Plasma membrane,Cytosol" NA NA 190000 "Cluster 14: Monocytes - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 68: Oligodendrocytes - Mixed function" Cytosol "Plasma membrane" "CAB003844: AB_562331, CAB016290: AB_628141, HPA006563: AB_1079626, HPA006564: AB_1079625" "unprognostic (3.06e-1)" "unprognostic (3.56e-2)" "unprognostic (1.38e-2)" "unprognostic (1.01e-1)" "unprognostic (1.53e-1)" "unprognostic (7.41e-3)" "unprognostic (7.43e-2)" "unprognostic (6.86e-3)" "unprognostic (4.93e-2)" "unprognostic (1.50e-1)" "unprognostic (2.09e-1)" "unprognostic (2.24e-2)" "unprognostic (5.50e-2)" "unprognostic (2.46e-1)" "unprognostic (1.83e-1)" "unprognostic (1.35e-3)" "unprognostic (8.77e-2)" 3.1 21.1 37.0 6.9 35.0 1.8 2.3 20.8 51.4 7.5 11.8 18.5 11.9 11.7 4.8 3.2 4.6 7.5 4.4 76.8 32.8 12.8 7.3 4.5 4.9 37.3 36.1 15.7 5.1 0.9 6.3 5.0 25.3 13.0 8.6 30.1 2.3 16.9 5.8 3.0 10.6 10.7 30.1 6.5 8.4 2.6 36.9 3.1 3.2 4.3 4.6 8.9 5.6 27.3 7.3 38.0 7.7 7.8 18.2 46.0 1.0 40.8 26.4 28.8 24.3 4.5 4.6 9.6 10.9 65.9 48.1 0.9 3.9 4.8 61.9 16.4 9.3 0.0 22.2 20.2 24.9 12.2 62.8 20.2 1.8 36.0 30.5 41.8 25.0 45.6 25.8 0.2 44.8 2.3 24.9 7.4 3.1 18.9 20.2 4.5 56.5 0.2 10.2 6.4 4.6 25.6 13.5 7.7 0.4 8.0 0.8 17.0 75.1 49.6 28.6 31.4 25.8 0.1 0.0 1.2 157.6 0.1 25.1 0.0 0.2 0.0 0.1 0.2 0.5 0.0 0.8 0.4 0.3 0.0 1.2 0.7 0.0 0.0 1.1 0.4 0.1 0.3 37.0 35.0 20.8 51.4 76.8 32.8 37.3 36.1 25.3 30.1 36.9 27.3 10.0 0.0 8.4 564.8 5.7 10.6 15.0 10.3 13.6 198.3 7.9 11.2 9.8 45.8 7.2 40.5 2.1 4.1 24.6 27.1 7.9 16.1 3.2 5.5 40.1 5.6 8.4 5.7 247.6 6.8 3.4 17.5 23.9 6.3 20.3 39.9 27.8 14.7 25.4 10.1 400.0 38.4 2.0 11.9 7.6 3.0 53.4 20.9 10.6 281.1 6.8 34.3 12.3 849.0 198.3 8.8 21.0 48.5 11.8 12.8 27.0 21.3 7.0 77.1 26.3 6.5 41.4 1.3 3.9 6.1 10.4 15.2 36.9 47.1 26.4 17.2 PRKCB "PKCβ, PKCB, PRKCB1, PRKCB2" ENSG00000166501 "Protein kinase C beta" P05771 16 23835983-24220611 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins, Transporters" "Adaptive immunity, Apoptosis, Immunity, Transcription, Transcription regulation" "Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 84.0;lymphoid tissue: 47.2" "Cell type enhanced" "Detected in many" "B-cells: 185.1;Bipolar cells: 208.6;Excitatory neurons: 877.7;Inhibitory neurons: 320.2;Kupffer cells: 221.9" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in many" 95 "amygdala: 28.9;basal ganglia: 53.9;cerebral cortex: 84.0;hippocampal formation: 35.3;white matter: 36.6" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "HEL: 161.8;HMC-1: 154.8;K-562: 234.9;THP-1: 72.7;U-937: 64.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003843, HPA048321, HPA054203" Approved Supported Nucleoplasm,Cytosol NA NA 380000 "Cluster 6: Non-specific - Transcription" "Cluster 10: Brain - Neuronal signaling" "Cluster 1: K-562 - Erythropoiesis" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm Cytosol "CAB003843: AB_562197, HPA048321: AB_2680357, HPA054203: AB_2682416" "unprognostic (1.53e-3)" "unprognostic (4.53e-4)" "unprognostic (2.52e-3)" "unprognostic (3.07e-2)" "unprognostic (1.72e-1)" "unprognostic (7.13e-3)" "unprognostic (2.06e-1)" "unprognostic (1.67e-3)" "unprognostic (3.19e-2)" "unprognostic (1.79e-1)" "unprognostic (7.38e-2)" "unprognostic (1.06e-1)" "unprognostic (3.17e-3)" "unprognostic (2.08e-1)" "unprognostic (2.12e-2)" "unprognostic (3.28e-1)" "unprognostic (4.95e-2)" 4.4 1.6 28.9 30.8 53.9 32.1 1.5 0.5 84.0 4.2 0.0 9.7 5.9 3.8 0.6 3.5 3.8 4.4 1.1 35.3 0.0 2.8 4.2 7.8 47.1 0.0 0.0 0.6 1.0 0.2 1.4 2.7 0.0 7.3 5.1 18.2 1.5 10.2 0.8 5.5 19.4 7.2 0.0 46.2 5.7 8.4 0.0 47.2 4.5 1.0 40.0 8.7 1.7 36.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 30.5 1.0 0.0 0.3 0.5 0.5 0.0 0.0 0.0 3.2 161.8 7.5 0.0 0.0 23.6 154.8 0.0 0.7 0.0 0.0 0.0 0.0 27.3 234.9 0.6 0.0 0.0 52.1 51.4 1.5 0.0 0.0 49.0 0.4 9.5 0.5 14.1 27.2 0.0 0.2 0.2 2.4 0.8 0.0 72.7 1.1 0.0 0.3 0.1 0.0 4.1 0.0 1.4 0.2 64.4 0.3 39.3 13.3 27.8 24.8 20.0 11.5 44.2 15.9 29.9 11.3 40.0 13.0 32.0 39.1 39.9 28.6 33.8 12.7 15.5 28.9 53.9 0.5 84.0 35.3 0.0 0.0 0.0 0.0 0.0 0.0 36.6 1.1 3.2 4.9 21.5 185.1 6.0 4.1 0.1 0.6 208.6 0.9 0.8 2.0 2.8 1.8 1.8 2.1 0.2 166.3 1.4 0.0 0.0 26.5 0.1 0.1 4.1 0.0 26.3 877.7 0.2 0.3 1.7 1.5 0.1 71.5 1.9 11.4 3.1 50.5 79.1 320.2 1.5 0.0 221.9 20.5 11.7 0.0 100.9 3.6 110.5 154.4 10.8 120.5 102.1 132.5 0.0 9.6 0.4 61.8 1.0 6.7 0.8 1.6 9.9 0.0 4.4 1.6 3.4 3.6 0.5 14.3 0.8 68.1 0.2 3.8 4.5 PRKCD ENSG00000163932 "Protein kinase C delta" Q05655 3 53156009-53192717 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 75.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 7 "dendritic cells: 57.0;granulocytes: 52.9;monocytes: 73.7" "Cell line enhanced" "Detected in all" "SK-BR-3: 267.7;THP-1: 194.0" "Group enriched" "Detected in all" 5 "basal ganglia: 121.4;thalamus: 334.6" "Low region specificity" "Detected in all" "HPA001863, HPA001890, CAB010469, CAB013225" Enhanced Enhanced "Endoplasmic reticulum,Golgi apparatus,Cytosol" NA NA 30000 "Cluster 52: Eosinophils - Transcription" "Cluster 64: Macrophages - Immune response" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "Endoplasmic reticulum, Golgi apparatus" "CAB010469: AB_632229, CAB013225: , HPA001863: AB_1079627, HPA001890: AB_1079628" "unprognostic (3.59e-1)" "unprognostic (4.85e-2)" "unprognostic (2.66e-2)" "unprognostic (1.90e-1)" "unprognostic (1.17e-1)" "unprognostic (6.97e-2)" "prognostic unfavorable (2.24e-4)" "prognostic favorable (9.01e-4)" "unprognostic (1.95e-2)" "unprognostic (1.42e-1)" "unprognostic (1.79e-1)" "unprognostic (2.89e-1)" "unprognostic (2.05e-1)" "unprognostic (1.73e-1)" "unprognostic (2.48e-2)" "unprognostic (2.06e-3)" "unprognostic (2.95e-3)" 46.1 59.7 10.4 45.4 11.1 90.3 28.9 4.4 11.7 25.9 7.3 43.5 54.8 9.1 39.1 32.7 42.3 32.8 19.6 12.8 11.0 25.6 8.8 44.3 46.8 9.9 8.5 13.6 33.2 20.7 8.2 20.5 7.5 39.3 41.5 2.2 25.9 31.9 6.8 34.0 55.7 16.2 9.5 54.2 65.1 20.8 9.0 16.3 41.8 9.2 62.1 44.2 23.2 12.3 33.5 14.4 5.2 8.7 35.9 21.6 46.2 20.4 25.7 24.5 23.7 34.4 31.9 86.5 8.3 45.6 42.9 14.5 34.1 49.8 20.6 75.2 23.6 50.1 18.3 32.0 23.6 64.8 103.4 17.1 35.8 25.6 23.2 21.8 22.4 9.3 9.7 11.8 36.1 85.0 7.0 81.0 13.0 51.5 23.0 7.6 13.6 20.6 25.5 72.8 8.3 6.5 15.4 267.7 39.6 24.0 22.6 194.0 31.5 11.7 14.4 15.4 19.2 18.1 33.6 45.9 27.6 116.4 22.6 51.8 73.7 50.1 3.6 71.3 2.2 6.2 2.1 2.5 57.0 8.2 2.2 2.0 52.9 6.9 47.7 16.3 2.6 24.1 10.4 11.1 4.4 11.7 12.8 11.0 9.9 8.5 7.5 9.5 9.0 12.3 4.3 3.2 23.5 2.0 25.7 29.2 26.3 8.0 23.9 0.3 11.8 4.3 6.4 14.3 16.1 14.7 0.0 3.1 24.7 61.8 3.9 8.9 34.5 18.5 4.4 2.7 26.5 5.2 3.4 10.7 16.0 6.7 54.0 17.8 5.7 8.9 3.3 2.3 44.8 1.7 4.2 37.1 4.1 47.4 43.0 75.6 9.0 41.5 10.6 20.6 44.9 2.0 8.2 1.0 0.5 13.2 55.4 6.8 25.8 19.7 64.5 13.1 16.5 0.2 6.6 6.5 12.1 23.1 3.7 23.9 27.8 8.8 10.0 10.4 23.0 34.6 PRKCE ENSG00000171132 "Protein kinase C epsilon" Q02156 2 45651345-46187990 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Cell adhesion, Cell cycle, Cell division, Immunity" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 34.5" "Cell type enhanced" "Detected in many" "Early spermatids: 206.5;Excitatory neurons: 394.4;Inhibitory neurons: 531.9;Late spermatids: 456.4;Oligodendrocyte precursor cells: 147.8" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in many" 4 "amygdala: 18.5;basal ganglia: 20.0;cerebral cortex: 34.5;hippocampal formation: 33.1;white matter: 17.1" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "REH: 27.0;TIME: 26.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001948, HPA008236, HPA044496" Enhanced Supported Supported "Vesicles,Plasma membrane,Intermediate filaments,Cytosol" NA NA "Cluster 37: B-cells - Transcription" "Cluster 58: Brain - Synaptic function" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Intermediate filaments, Cytosol" "Vesicles, Plasma membrane" "CAB001948: , HPA008236: , HPA044496: AB_2678959" "unprognostic (1.10e-1)" "unprognostic (1.78e-1)" "unprognostic (2.27e-1)" "prognostic unfavorable (2.42e-4)" "unprognostic (9.61e-2)" "unprognostic (5.70e-2)" "unprognostic (1.51e-1)" "prognostic favorable (9.62e-4)" "unprognostic (3.05e-1)" "unprognostic (6.72e-2)" "unprognostic (7.49e-3)" "unprognostic (9.99e-2)" "prognostic favorable (2.63e-7)" "unprognostic (1.21e-1)" "unprognostic (7.11e-2)" "unprognostic (6.43e-3)" "unprognostic (2.23e-2)" 4.4 5.6 18.5 3.7 20.0 8.0 4.2 5.5 34.5 4.6 0.0 5.7 2.6 4.4 2.3 4.1 5.7 3.0 6.2 33.1 0.0 10.0 12.5 20.1 5.7 6.0 0.2 2.8 3.3 9.4 5.2 8.3 4.4 2.9 3.3 15.4 2.7 3.0 7.6 2.7 3.5 4.1 0.0 3.9 4.1 7.6 1.1 3.1 4.9 5.3 4.2 4.9 3.4 17.1 7.7 2.7 3.8 3.8 5.8 6.7 3.1 4.9 9.5 4.3 4.5 0.7 7.0 11.3 4.8 5.5 6.1 1.8 2.5 2.8 6.1 6.9 4.4 0.1 1.8 1.5 6.5 0.9 3.8 5.8 3.0 6.5 4.7 3.6 16.0 2.4 1.6 2.6 5.0 3.8 3.8 0.5 1.3 4.2 1.4 27.0 18.3 12.4 3.9 5.1 2.6 5.7 2.4 7.6 17.1 1.4 6.1 2.6 26.8 8.2 8.5 6.1 5.1 0.0 0.0 9.3 6.7 6.3 8.4 0.0 0.5 0.7 0.3 0.1 0.4 1.5 0.2 0.2 0.8 1.8 0.5 0.1 0.1 0.4 0.6 0.3 0.0 0.3 18.5 20.0 5.5 34.5 33.1 0.0 6.0 0.2 4.4 0.0 1.1 17.1 12.6 6.4 9.2 90.4 20.7 5.0 8.4 5.0 9.1 55.3 6.4 5.7 11.9 8.6 17.2 11.0 14.6 0.5 9.3 6.1 3.9 3.7 206.5 6.8 7.0 13.8 7.7 0.4 394.4 3.8 7.2 8.7 11.2 6.9 7.0 2.9 13.2 12.5 2.8 11.8 531.9 5.8 0.0 19.0 10.7 456.4 5.3 11.5 14.2 70.3 9.4 6.5 1.0 147.8 96.0 3.6 2.9 6.0 4.2 5.3 4.1 30.2 19.3 7.6 13.1 2.9 6.4 2.8 2.3 9.0 4.8 2.9 6.8 1.2 6.2 8.8 PRKCG "MGC57564, PKCγ, PKCC, PKCG, SCA14" ENSG00000126583 "Protein kinase C gamma" P05129 19 53879190-53907652 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Biological rhythms" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, FDA approved drug targets, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 20 "brain: 103.3" "Cell type enhanced" "Detected in some" "Excitatory neurons: 22.6;Glandular and luminal cells: 5.1;Horizontal cells: 5.0;Inhibitory neurons: 12.8" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in many" "hippocampal formation: 103.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 2.2;OE19: 4.0;SH-SY5Y: 1.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054560 Enhanced NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 21: OE19 - Mitochondria" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA054560: AB_2682523" "unprognostic (7.14e-2)" "unprognostic (5.42e-2)" "unprognostic (1.85e-1)" "unprognostic (3.86e-2)" "unprognostic (1.41e-1)" "unprognostic (5.38e-2)" "unprognostic (5.96e-2)" "unprognostic (4.46e-2)" "unprognostic (2.09e-1)" "unprognostic (2.64e-2)" "unprognostic (7.48e-3)" "unprognostic (2.68e-1)" "unprognostic (2.22e-7)" "unprognostic (2.41e-2)" "unprognostic (2.61e-1)" "unprognostic (1.06e-1)" "unprognostic (1.83e-1)" 0.1 0.0 47.5 0.2 44.8 0.9 0.0 5.8 64.8 0.0 0.0 0.3 0.4 0.1 0.0 0.0 0.5 0.1 0.0 103.3 4.0 0.0 0.0 0.0 0.0 0.0 3.5 0.1 1.8 3.9 1.4 0.0 0.0 0.0 0.2 0.3 0.1 0.0 0.1 0.0 0.5 0.1 0.6 0.0 0.6 5.2 12.6 3.4 0.0 0.2 0.0 0.0 0.0 18.3 0.1 2.2 0.4 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.5 0.6 0.1 0.6 0.0 0.2 0.2 1.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.9 0.0 0.0 0.2 0.0 0.4 0.0 0.5 0.0 0.0 0.0 0.2 0.2 0.0 0.3 4.0 0.1 0.4 0.2 0.0 0.4 0.0 0.0 1.5 0.6 0.0 0.0 0.7 0.7 0.0 0.4 0.0 0.7 0.0 0.0 0.6 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 47.5 44.8 5.8 64.8 103.3 4.0 0.0 3.5 0.0 0.6 12.6 18.3 1.1 0.0 0.0 1.0 0.7 0.1 0.1 0.0 0.0 0.0 2.3 4.6 0.7 0.0 0.0 0.0 0.0 0.0 0.8 0.2 0.0 0.1 4.2 1.2 2.0 0.5 0.0 0.0 22.6 0.0 0.2 0.6 2.0 5.1 0.0 0.0 0.0 0.0 0.1 5.0 12.8 1.5 0.0 0.0 0.0 1.8 0.0 0.6 0.0 2.8 0.0 0.0 0.0 3.0 2.0 0.2 0.0 0.0 1.0 0.1 0.0 0.0 0.1 0.2 0.0 4.0 0.4 2.9 0.9 0.1 0.0 0.0 0.2 0.0 0.4 0.1 PRKCH "PKC-L, PKCL, PRKCL" ENSG00000027075 "Protein kinase C eta" P24723 14 61187559-61550976 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Differentiation "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "dendritic cells: 128.4;Microglial cells: 267.9;NK-cells: 229.6;T-cells: 130.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 11 "gdT-cell: 116.5;MAIT T-cell: 91.3;memory CD4 T-cell: 88.0;memory CD8 T-cell: 137.0;naive CD4 T-cell: 106.9;naive CD8 T-cell: 105.5;NK-cell: 117.1;T-reg: 79.8" "Group enriched" "Detected in all" 14 "NK-cells: 117.1;T-cells: 137.0" "Cell line enhanced" "Detected in many" "BEWO: 81.8;HUVEC TERT2: 108.7;MOLT-4: 75.8;RT4: 46.4;TIME: 72.0" "Group enriched" "Detected in all" 6 "basal ganglia: 28.0;thalamus: 17.9" "Low region specificity" "Detected in all" "HPA026294, HPA053709" Approved Approved "Plasma membrane,Cytosol" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 3: T-cells - Adaptive immune response" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "Plasma membrane" "HPA026294: AB_10603988, HPA053709: AB_2682237" "unprognostic (1.42e-1)" "unprognostic (3.89e-3)" "unprognostic (1.78e-1)" "unprognostic (1.96e-3)" "unprognostic (1.04e-1)" "prognostic favorable (8.55e-6)" "unprognostic (1.14e-2)" "unprognostic (2.97e-2)" "unprognostic (4.14e-1)" "unprognostic (1.94e-1)" "unprognostic (7.96e-2)" "unprognostic (1.60e-1)" "unprognostic (1.52e-3)" "unprognostic (1.13e-1)" "unprognostic (4.14e-2)" "unprognostic (6.98e-2)" "unprognostic (4.73e-3)" 26.6 7.8 21.1 21.9 30.2 24.2 21.9 12.4 15.7 20.6 9.5 8.9 9.5 14.5 10.9 30.0 13.6 19.7 19.2 13.2 13.9 14.5 10.3 35.3 55.2 19.3 21.7 5.9 8.4 14.2 15.0 32.5 19.4 15.8 8.8 3.1 28.3 11.4 14.2 23.7 16.6 18.1 18.6 38.5 9.6 7.5 29.9 65.8 21.1 18.1 38.5 25.3 21.7 15.5 18.1 6.3 0.8 4.9 2.8 0.6 81.8 0.3 1.5 0.8 0.8 1.9 10.5 0.3 12.4 0.1 1.6 12.3 0.6 13.5 1.4 2.2 7.9 0.1 2.0 0.7 1.2 0.0 2.4 2.2 13.8 0.7 9.4 1.2 108.7 35.4 0.2 0.4 6.2 32.7 75.8 0.7 1.4 12.9 8.4 6.3 3.2 0.2 0.2 46.4 3.2 5.1 2.1 16.2 10.2 14.5 15.9 1.4 72.0 2.1 14.0 2.1 0.9 1.4 0.2 0.6 3.1 1.1 3.6 0.8 3.0 2.4 116.5 1.9 91.3 2.2 88.0 137.0 9.2 1.4 106.9 105.5 5.9 117.1 1.1 3.0 79.8 84.0 21.1 30.2 12.4 15.7 13.2 13.9 19.3 21.7 19.4 18.6 29.9 15.5 59.7 6.4 11.4 2.0 6.6 18.7 16.4 8.3 15.9 0.4 15.0 9.3 9.0 10.0 15.5 0.0 0.0 27.6 128.4 0.6 3.9 6.0 32.6 10.3 2.1 70.8 11.9 18.1 1.7 6.8 21.2 5.0 7.1 20.9 1.3 15.4 68.9 2.0 6.0 0.0 3.1 2.7 2.0 14.4 6.9 6.0 1.8 15.4 16.0 267.9 8.9 7.0 229.6 4.5 1.8 5.4 4.3 6.8 26.6 14.7 4.6 1.2 9.2 0.5 0.0 4.4 5.2 0.1 2.4 18.1 26.7 48.3 130.5 1.6 1.3 26.0 PRKCI "DXS1179E, PKCI" ENSG00000163558 "Protein kinase C iota" P41743 3 170222424-170305977 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets, Proto-oncogene, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026574, HPA038635" Approved Supported "Microtubules,Cytokinetic bridge,Cytosol" Yes No "Cluster 15: NK-cells - Transcription" "Cluster 46: Fibroblasts - ECM organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Cytosol "Microtubules, Cytokinetic bridge" "HPA026574: AB_1855428, HPA038635: AB_2676124" "unprognostic (2.26e-1)" "unprognostic (6.75e-2)" "unprognostic (4.57e-2)" "prognostic unfavorable (3.93e-6)" "unprognostic (1.59e-1)" "unprognostic (1.84e-2)" "prognostic unfavorable (3.02e-4)" "unprognostic (2.52e-1)" "unprognostic (7.10e-2)" "unprognostic (1.73e-2)" "prognostic unfavorable (1.22e-4)" "unprognostic (5.32e-3)" "prognostic favorable (3.10e-4)" "unprognostic (1.16e-1)" "unprognostic (2.65e-1)" "unprognostic (1.06e-1)" "unprognostic (9.73e-2)" 6.7 5.0 2.0 6.9 2.4 2.6 10.4 2.0 3.2 12.7 0.3 12.4 11.6 11.0 8.2 15.1 15.9 11.4 6.9 3.4 1.1 13.5 7.3 16.6 4.6 0.4 0.2 13.6 7.0 13.0 3.1 10.9 0.5 17.3 13.1 6.2 17.5 12.7 6.2 6.9 10.8 11.0 0.2 5.2 34.5 12.5 0.9 10.9 24.5 9.8 10.4 16.1 6.2 1.1 81.6 20.2 20.0 21.6 17.3 23.9 32.2 20.4 29.9 26.4 28.3 29.7 38.6 24.7 65.3 28.8 36.4 37.3 37.9 40.0 44.8 18.2 23.5 22.9 24.3 16.6 27.9 20.9 10.0 21.8 27.5 22.6 35.1 42.8 20.9 13.3 25.8 19.8 27.4 28.0 30.5 8.5 42.3 86.4 22.1 21.8 30.7 41.2 42.3 24.4 31.5 25.8 44.1 57.7 20.0 29.5 63.0 14.5 22.4 27.5 21.1 26.0 34.3 33.9 34.9 35.2 19.8 16.4 11.0 0.0 0.6 0.4 1.1 0.6 1.7 0.9 1.5 2.0 0.8 1.2 1.6 0.9 0.3 2.6 0.5 0.8 1.1 0.7 2.0 2.4 2.0 3.2 3.4 1.1 0.4 0.2 0.5 0.2 0.9 1.1 17.6 73.7 82.1 23.2 5.8 57.1 49.5 39.8 30.7 16.4 29.0 19.7 16.2 24.3 45.3 49.7 14.6 30.2 15.0 29.0 25.4 16.5 8.4 42.0 29.7 20.5 29.3 10.5 77.2 22.0 26.6 32.2 59.7 72.3 8.8 20.4 17.5 17.7 10.0 15.2 55.2 28.3 50.8 18.6 26.8 6.8 23.3 11.6 17.8 22.5 12.7 8.8 6.2 33.2 33.5 55.2 18.6 28.6 29.4 99.4 18.7 20.4 31.9 9.4 19.7 23.7 18.7 15.8 20.6 38.5 63.6 20.7 14.8 14.3 28.5 80.1 PRKCQ ENSG00000065675 "Protein kinase C theta" Q04759 10 6427143-6580301 "Cancer-related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Immunity, Inflammatory response" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "lymphoid tissue: 33.6;skeletal muscle: 124.5;tongue: 112.6" "Cell type enhanced" "Detected in many" "Astrocytes: 22.9;dendritic cells: 22.4;NK-cells: 32.0;Oligodendrocyte precursor cells: 24.6;Oligodendrocytes: 75.2;T-cells: 31.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 9 "gdT-cell: 23.0;MAIT T-cell: 18.0;memory CD4 T-cell: 24.5;memory CD8 T-cell: 24.5;naive CD4 T-cell: 19.1;naive CD8 T-cell: 17.9;NK-cell: 13.3;T-reg: 39.7" "Group enriched" "Detected in many" 11 "NK-cells: 13.3;T-cells: 39.7" "Cell line enhanced" "Detected in many" "HEL: 57.8;JURKAT: 40.0;MOLT-4: 43.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA065279, HPA073098" Enhanced "Centriolar satellite" NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" "Centriolar satellite" "HPA065279: AB_2685453, HPA073098: AB_2686571" "unprognostic (6.61e-3)" "unprognostic (2.12e-1)" "unprognostic (1.87e-1)" "unprognostic (1.48e-1)" "unprognostic (1.50e-1)" "unprognostic (2.24e-1)" "unprognostic (2.69e-3)" "unprognostic (2.46e-1)" "unprognostic (8.40e-2)" "unprognostic (2.66e-1)" "unprognostic (1.17e-1)" "unprognostic (3.22e-1)" "unprognostic (5.26e-2)" "unprognostic (7.74e-2)" "unprognostic (2.79e-1)" "prognostic unfavorable (5.27e-4)" "unprognostic (3.51e-2)" 0.8 0.7 5.3 5.2 8.5 5.7 0.9 6.1 6.3 1.6 12.1 1.4 1.5 2.5 8.3 2.2 3.9 1.5 0.3 5.5 8.2 10.9 1.0 5.3 12.3 6.5 8.6 1.3 3.4 0.7 0.8 0.2 6.4 1.8 1.7 1.5 1.4 1.1 124.5 0.3 3.3 0.7 5.5 5.0 2.1 1.1 7.2 33.6 14.9 112.6 9.4 2.2 0.6 9.8 0.1 5.3 0.1 0.0 0.0 0.0 1.6 0.0 0.0 0.2 0.2 0.4 3.4 0.3 0.0 0.0 0.0 0.0 3.3 6.0 0.0 0.0 3.9 57.8 0.0 0.4 0.7 2.8 0.6 0.3 3.5 0.1 0.2 0.0 0.5 40.0 12.8 0.1 0.0 0.0 43.9 8.0 5.8 0.5 0.0 8.5 1.3 0.0 11.6 2.9 0.4 2.1 0.0 0.0 0.0 3.4 0.0 5.8 0.0 0.0 5.6 0.0 0.0 0.1 0.0 0.0 0.0 7.1 0.0 2.4 0.1 0.3 23.0 0.4 18.0 0.1 24.5 24.5 0.2 0.0 19.1 17.9 1.6 13.3 0.0 0.0 39.7 10.5 5.3 8.5 6.1 6.3 5.5 8.2 6.5 8.6 6.4 5.5 7.2 9.8 0.2 3.2 7.0 22.9 0.8 0.0 0.3 0.3 0.6 1.6 0.3 0.3 0.4 0.0 0.7 1.8 0.0 0.0 22.4 0.0 7.9 0.3 2.1 0.5 1.2 0.2 1.8 8.0 13.7 0.8 0.1 0.7 1.5 3.0 1.3 8.2 1.1 0.0 0.5 0.0 14.7 0.5 0.0 1.3 0.5 5.6 0.0 1.7 0.0 7.5 0.8 1.2 32.0 24.6 75.2 0.1 0.1 0.0 10.2 0.2 0.0 0.3 0.9 0.4 0.0 4.2 0.4 1.0 2.2 0.5 0.0 0.0 31.7 0.3 0.4 0.1 PRKCSH "G19P1, GIIB, PCLD, PLD1, VASAP-60" ENSG00000130175 "Protein kinase C substrate 80K-H" P14314 19 11435284-11450968 "Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004465, HPA041940, HPA043560" Supported Supported "Endoplasmic reticulum" "Intracellular and membrane" NA NA 55000000 "Cluster 41: Basophils - Cellular respiration" "Cluster 50: Non-specific - Ribosome" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 32: Non-specific - Translation" "Endoplasmic reticulum" "CAB004465: AB_626622, HPA041940: AB_2677758, HPA043560: AB_2678553" "unprognostic (2.75e-1)" "unprognostic (1.67e-1)" "unprognostic (2.45e-2)" "unprognostic (2.14e-1)" "unprognostic (5.65e-2)" "unprognostic (2.63e-2)" "unprognostic (2.52e-2)" "unprognostic (5.52e-2)" "unprognostic (1.16e-1)" "unprognostic (2.07e-3)" "unprognostic (1.28e-2)" "unprognostic (3.15e-2)" "prognostic unfavorable (7.69e-4)" "unprognostic (1.63e-3)" "unprognostic (2.10e-1)" "unprognostic (3.44e-1)" "unprognostic (1.18e-1)" 115.3 107.6 76.4 81.2 86.7 169.6 117.6 85.1 97.6 144.0 91.4 119.7 120.0 123.0 113.0 106.5 126.2 92.0 90.4 76.4 82.0 108.8 159.9 105.5 93.3 89.9 83.9 196.9 186.2 116.3 118.3 108.8 85.9 108.5 98.9 46.6 145.9 97.8 74.8 129.3 121.7 78.5 79.6 111.2 124.9 88.5 83.3 83.9 135.5 44.9 86.2 109.9 122.6 88.8 274.8 216.7 211.6 391.5 351.2 426.4 241.5 305.5 387.6 331.5 302.7 328.3 327.5 204.4 478.1 409.2 165.4 283.4 226.3 309.6 292.1 193.3 173.5 178.0 269.4 268.8 258.0 263.0 236.4 404.5 228.6 312.5 261.4 425.6 232.8 210.1 204.8 422.4 289.0 470.1 187.9 322.1 485.0 129.7 283.3 201.8 215.3 505.6 223.2 260.1 146.9 291.5 282.3 280.4 280.5 200.8 292.5 296.7 263.6 437.1 198.2 416.0 361.0 471.9 575.3 132.3 330.1 276.8 306.5 38.8 47.2 45.1 37.9 36.2 42.6 35.9 31.8 36.4 36.1 38.7 30.2 33.1 56.3 32.8 41.2 75.7 37.5 39.5 76.4 86.7 85.1 97.6 76.4 82.0 89.9 83.9 85.9 79.6 83.3 88.8 45.2 12.8 16.9 15.3 65.1 41.8 72.2 90.0 39.9 18.2 56.9 47.5 10.5 71.4 44.9 64.4 33.3 174.9 54.6 152.0 33.2 88.7 18.1 47.4 65.0 52.0 58.8 40.6 12.3 127.5 189.1 62.6 70.3 67.2 41.9 104.5 60.3 86.4 93.4 10.1 12.5 123.2 65.1 80.0 43.4 55.9 78.6 59.3 53.4 14.0 81.4 59.8 61.8 6.0 39.0 89.0 132.8 72.6 91.4 45.9 187.8 62.7 32.7 30.2 39.5 39.8 52.0 36.8 55.2 49.5 37.8 143.5 55.5 84.2 128.2 66.6 PRKCZ PKC2 ENSG00000067606 "Protein kinase C zeta" Q05513 1 2050411-2185395 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Inflammatory response" "Kinase, Serine/threonine-protein kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 58.0" "Group enriched" "Detected in many" 4 "Late spermatids: 708.3;Syncytiotrophoblasts: 1107.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 6 "eosinophil: 16.3" "Lineage enriched" "Detected in many" 6 "granulocytes: 16.3" "Cell line enhanced" "Detected in many" "BEWO: 44.5;OE19: 41.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021851 Enhanced Supported "Plasma membrane,Cytosol" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 6: Brain - Smell perception" "Cluster 28: BEWO - Transcription regulation" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Cytosol "Plasma membrane" "HPA021851: AB_1855433" "unprognostic (1.25e-2)" "unprognostic (2.61e-1)" "unprognostic (5.10e-2)" "unprognostic (1.14e-2)" "unprognostic (2.08e-1)" "unprognostic (3.61e-2)" "unprognostic (1.73e-2)" "unprognostic (5.13e-2)" "unprognostic (1.18e-1)" "unprognostic (3.10e-1)" "unprognostic (1.12e-1)" "unprognostic (2.86e-1)" "prognostic favorable (1.64e-9)" "unprognostic (3.57e-2)" "unprognostic (3.27e-2)" "unprognostic (1.39e-1)" "unprognostic (7.85e-2)" 1.7 11.1 23.6 4.6 25.7 2.1 5.6 58.0 41.3 4.3 0.0 13.2 29.3 2.2 7.8 16.0 9.5 4.4 9.7 23.7 10.2 16.0 11.0 31.6 8.0 18.6 8.3 2.7 12.5 14.7 17.6 43.8 19.0 8.4 11.3 14.8 10.8 3.9 0.3 13.8 28.0 1.6 5.6 10.5 8.9 31.9 7.2 3.7 21.8 0.6 7.8 5.8 8.0 24.8 14.7 9.7 3.4 17.2 0.0 0.0 44.5 1.2 0.5 11.1 0.7 23.8 31.0 0.1 27.4 3.9 9.4 25.4 20.5 25.5 7.9 1.0 21.8 0.0 15.2 33.5 3.2 0.1 11.0 0.6 14.9 0.0 8.6 0.0 0.0 4.0 6.6 0.2 0.2 17.9 0.9 0.0 6.4 41.9 22.5 0.0 0.0 5.1 18.6 16.0 24.1 18.7 11.6 27.5 5.2 28.7 17.7 4.0 0.0 0.1 13.1 0.1 0.1 6.8 1.3 0.3 1.2 0.3 16.8 0.3 0.0 16.3 0.5 0.3 2.5 0.3 0.9 0.6 0.0 0.4 0.8 0.3 1.1 0.9 0.0 0.3 0.9 0.3 23.6 25.7 58.0 41.3 23.7 10.2 18.6 8.3 19.0 5.6 7.2 24.8 0.9 121.8 72.2 2.3 6.5 13.0 11.8 11.0 10.2 27.1 11.3 11.0 1.4 5.7 21.1 7.3 4.2 118.7 7.5 48.9 7.9 12.3 224.4 14.0 4.7 6.3 10.2 6.6 39.5 10.7 66.3 3.1 17.9 11.7 8.2 12.5 10.0 16.5 14.5 62.2 35.2 25.5 10.2 0.8 2.9 708.3 9.6 4.4 7.2 2.8 4.5 19.1 8.2 13.0 41.3 14.2 45.7 8.6 7.4 19.5 78.4 24.7 22.1 25.9 0.0 0.3 4.1 28.3 28.4 13.4 13.4 1107.9 9.8 2.6 31.3 14.3 PRKD1 "PKC-mu, PKCM, PKD, PRKCM" ENSG00000184304 "Protein kinase D1" Q15139 14 29576479-30191898 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Angiogenesis, Apoptosis, Differentiation, Immunity, Inflammatory response, Innate immunity, Neurogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Ectodermal dysplasia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 362.1;Excitatory neurons: 147.4;Inhibitory neurons: 171.1;Microglial cells: 89.0;Oligodendrocyte precursor cells: 390.6" "Cancer enhanced" "Detected in all" "prostate cancer: 10.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 21.6;fHDF/TERT166: 19.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB018367, HPA029834" Uncertain Supported "Plasma membrane,Cytosol" "Intracellular and membrane" NA NA "Cluster 21: Non-specific - Transcription" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 68: Oligodendrocytes - Mixed function" "Plasma membrane" Cytosol "CAB018367: AB_2253119, HPA029834: AB_10602821" "unprognostic (5.35e-2)" "unprognostic (3.20e-1)" "unprognostic (2.27e-2)" "unprognostic (6.70e-2)" "unprognostic (2.37e-1)" "unprognostic (1.92e-1)" "unprognostic (1.08e-3)" "unprognostic (8.88e-2)" "unprognostic (2.37e-2)" "unprognostic (5.29e-2)" "unprognostic (7.08e-2)" "unprognostic (1.56e-1)" "prognostic favorable (2.44e-5)" "unprognostic (9.45e-4)" "unprognostic (1.99e-1)" "prognostic unfavorable (2.91e-4)" "unprognostic (3.89e-1)" 8.0 9.6 5.6 2.2 8.0 0.0 7.7 6.5 6.7 6.4 3.7 9.5 1.0 7.9 3.5 2.1 6.5 4.4 6.1 7.5 7.5 17.5 1.6 7.5 0.3 8.6 8.6 11.2 5.4 10.6 5.6 1.9 8.7 14.7 1.3 4.7 2.9 9.3 1.6 2.8 3.6 6.3 8.9 2.3 4.6 11.7 8.1 2.4 5.9 2.6 0.5 13.1 4.6 10.3 0.0 4.4 4.8 3.1 21.6 16.5 0.1 14.1 10.4 16.7 7.3 0.0 0.3 0.0 1.9 19.4 4.0 0.1 7.9 2.1 6.8 0.0 6.2 0.0 0.0 0.5 8.8 0.0 0.1 18.4 0.3 1.4 1.5 6.1 2.6 0.0 1.4 0.4 17.4 1.8 0.0 0.0 2.6 0.0 9.6 0.0 6.3 5.2 9.7 6.6 4.3 13.0 2.6 0.0 4.5 4.6 0.0 0.1 5.6 13.6 6.7 1.0 3.7 0.0 0.0 0.0 3.5 0.0 14.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.6 8.0 6.5 6.7 7.5 7.5 8.6 8.6 8.7 8.9 8.1 10.3 4.6 0.0 7.4 362.1 0.2 0.5 4.8 0.4 0.6 1.4 1.4 1.5 1.2 10.0 0.0 12.9 6.2 0.0 0.0 0.1 29.4 2.4 39.5 2.8 9.2 6.1 3.0 2.7 147.4 4.2 0.1 6.4 0.5 8.4 0.0 18.7 10.8 2.5 0.2 1.7 171.1 0.2 0.0 1.6 0.9 16.9 7.5 0.7 7.2 89.0 0.0 16.7 0.0 390.6 76.6 2.0 0.1 12.8 0.4 12.4 0.2 4.5 0.1 2.9 0.0 13.3 4.5 3.2 7.8 0.0 0.9 0.3 0.6 29.6 0.1 1.3 PRKD2 "DKFZP586E0820, HSPC187, PKD2" ENSG00000105287 "Protein kinase D2" Q9BZL6 19 46674275-46717127 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Adaptive immunity, Angiogenesis, Cell adhesion, Immunity" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "U-266/84: 149.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021490, HPA056727" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 64: Macrophages - Immune response" "Cluster 16: U-266 - Nucleosome" "Cluster 57: B-cells - Immune response" Nucleoplasm Cytosol "HPA021490: AB_1855708, HPA056727: AB_2683217" "unprognostic (3.01e-2)" "unprognostic (1.22e-2)" "unprognostic (1.23e-3)" "unprognostic (7.06e-2)" "unprognostic (8.91e-2)" "unprognostic (1.99e-2)" "unprognostic (8.79e-3)" "unprognostic (2.61e-1)" "unprognostic (6.22e-2)" "unprognostic (4.21e-3)" "unprognostic (8.89e-2)" "unprognostic (2.74e-1)" "unprognostic (3.45e-3)" "unprognostic (1.04e-2)" "unprognostic (7.19e-2)" "unprognostic (4.34e-2)" "prognostic favorable (9.15e-4)" 29.0 11.5 7.2 23.6 7.3 29.4 29.3 5.4 7.7 26.6 12.5 20.3 17.1 21.8 4.7 27.5 24.1 11.2 13.8 6.1 6.0 19.2 13.8 34.3 31.1 10.0 6.3 21.8 19.1 8.3 24.0 11.1 6.8 23.9 7.1 4.4 24.7 10.0 8.0 46.8 29.9 6.0 6.0 54.3 20.3 6.6 7.7 25.6 28.9 4.8 21.2 19.5 26.9 6.6 19.6 34.5 12.8 16.6 7.3 6.4 15.1 11.5 13.2 19.6 19.7 19.7 21.0 22.3 16.3 13.2 13.2 27.5 9.5 26.0 5.9 19.8 17.5 25.9 11.5 10.2 12.8 21.2 34.7 11.0 15.8 12.7 9.8 12.8 30.1 21.5 14.6 35.4 7.0 23.8 32.7 53.1 9.7 27.4 17.4 25.8 5.8 37.5 11.4 32.7 7.7 22.4 18.8 18.8 4.6 10.6 11.6 7.5 17.6 8.7 18.8 7.1 10.0 31.8 149.1 13.5 8.5 17.7 11.0 0.6 0.7 2.6 3.9 0.7 3.3 4.3 3.9 4.3 0.3 4.1 3.3 3.3 5.3 2.2 0.5 0.0 2.9 1.5 7.2 7.3 5.4 7.7 6.1 6.0 10.0 6.3 6.8 6.0 7.7 6.6 37.8 9.6 9.9 5.9 46.5 22.0 32.0 13.2 22.8 6.4 13.9 11.3 17.2 12.8 13.0 9.2 0.0 13.8 17.5 43.6 7.9 18.6 1.2 15.3 6.7 37.2 21.6 4.0 6.5 28.2 13.8 9.6 23.4 15.0 14.5 14.1 37.1 8.5 9.0 1.7 2.8 21.7 4.1 12.3 11.4 3.1 11.8 8.3 12.4 11.2 9.3 6.5 42.2 4.0 3.1 29.5 35.1 6.8 47.0 22.9 34.1 9.3 15.6 4.4 13.1 6.1 7.6 2.9 17.9 21.2 26.7 29.7 31.9 6.6 15.3 30.2 PRKD3 "EPK2, PRKCN" ENSG00000115825 "Protein kinase D3" O94806 2 37250502-37324833 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "SK-MEL-30: 152.1;U-266/84: 159.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029529 Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 16: U-266 - Nucleosome" "Cluster 46: Photoreceptor cells - Phototransduction" "Nucleoplasm, Cytosol" "HPA029529: AB_10602082" "unprognostic (1.39e-1)" "unprognostic (7.34e-2)" "prognostic favorable (4.84e-4)" "unprognostic (1.23e-2)" "unprognostic (5.61e-2)" "unprognostic (2.08e-1)" "prognostic unfavorable (3.47e-4)" "unprognostic (1.10e-1)" "unprognostic (1.16e-1)" "unprognostic (2.52e-2)" "unprognostic (2.93e-1)" "unprognostic (1.81e-1)" "unprognostic (7.62e-3)" "unprognostic (2.49e-2)" "unprognostic (1.18e-1)" "unprognostic (1.36e-1)" "unprognostic (1.35e-1)" 15.1 19.9 6.1 18.1 6.8 8.7 14.4 7.8 7.3 19.3 3.9 16.4 8.2 18.9 13.8 10.7 9.9 13.3 9.8 6.0 7.5 12.0 10.1 14.7 29.1 7.2 7.1 18.0 9.1 11.7 6.5 14.9 7.8 11.7 11.0 41.6 10.5 12.5 14.9 12.2 10.3 16.2 7.6 23.4 12.4 23.3 8.1 20.7 13.4 12.1 28.9 15.5 9.5 7.1 38.8 14.3 44.4 36.1 33.2 55.1 31.5 25.0 48.8 29.1 28.7 23.4 14.0 58.5 20.1 39.6 43.2 15.0 31.1 31.9 39.0 72.3 38.7 39.2 24.4 17.8 13.8 26.2 21.5 26.0 16.2 46.2 29.7 26.6 52.6 19.9 32.3 70.9 33.8 6.1 11.6 21.6 45.4 0.4 14.2 40.8 67.9 51.8 18.9 42.1 32.5 81.0 24.6 13.9 152.1 22.8 15.1 25.1 47.7 80.0 40.5 31.5 28.5 78.1 159.7 68.2 27.8 11.2 48.7 6.9 7.7 6.1 9.5 6.7 8.1 10.6 8.5 8.1 7.7 14.6 9.6 10.8 1.4 6.9 3.6 8.1 4.4 3.6 6.1 6.8 7.8 7.3 6.0 7.5 7.2 7.1 7.8 7.6 8.1 7.1 41.4 41.7 17.8 21.9 60.2 37.9 32.1 24.1 14.8 47.6 14.7 15.5 9.1 27.1 16.6 18.4 68.8 11.2 37.7 7.3 3.9 13.1 57.1 8.3 38.5 48.0 18.8 12.0 24.8 10.6 37.0 33.0 20.4 14.1 76.9 26.8 44.3 12.2 12.8 43.7 18.7 6.9 22.4 31.2 91.2 100.6 33.5 24.4 49.8 68.4 32.7 15.9 27.8 37.7 12.6 16.1 4.3 30.9 60.2 34.3 6.6 8.6 10.3 118.8 26.3 27.5 24.0 54.7 39.9 10.6 23.9 9.7 33.5 29.1 12.3 34.1 PRKDC "DNA-PKC, DNA-PKcs, DNAPK, DNAPKc, DNPK1, HYRC, HYRC1, p350, p460, XRCC7" ENSG00000253729 "Protein kinase, DNA-activated, catalytic subunit" P78527 8 47773111-47960178 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, DNA damage, DNA recombination, DNA repair, Immunity, Innate immunity, Ribosome biogenesis" "DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, SCID" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005167, HPA035174" Supported Enhanced Nucleoplasm NA NA 250000 "Cluster 6: Non-specific - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 36: HEL - Hemostasis" "Cluster 36: Stromal cells - Cell proliferation" Nucleoplasm "CAB005167: AB_2172845, HPA035174: AB_2674504" "unprognostic (3.14e-2)" "unprognostic (3.02e-3)" "unprognostic (1.56e-2)" "prognostic unfavorable (1.03e-4)" "unprognostic (8.95e-2)" "unprognostic (1.34e-1)" "unprognostic (7.70e-3)" "unprognostic (5.74e-2)" "unprognostic (1.12e-2)" "unprognostic (1.60e-2)" "unprognostic (7.76e-3)" "unprognostic (7.77e-2)" "unprognostic (2.84e-2)" "unprognostic (2.32e-1)" "unprognostic (2.20e-1)" "unprognostic (6.76e-3)" "unprognostic (2.15e-2)" 17.3 16.8 8.6 14.1 10.7 19.2 16.1 9.8 11.9 18.2 10.8 16.2 7.0 20.1 8.0 24.0 18.3 7.4 16.7 10.6 9.3 14.8 14.0 14.8 17.9 10.4 10.0 19.8 18.0 14.0 16.3 10.9 9.8 13.5 11.6 23.8 16.0 9.2 26.4 19.8 17.2 12.1 10.6 18.8 16.6 18.3 9.6 27.8 13.4 15.0 17.1 18.7 17.5 14.3 123.5 103.4 98.4 93.9 59.9 63.0 41.6 51.2 49.9 70.3 68.9 68.0 39.6 117.1 43.1 63.3 52.3 68.5 131.3 70.2 109.3 26.3 81.8 230.2 92.1 83.7 25.8 88.6 46.0 45.9 22.5 111.3 115.3 27.1 73.4 79.5 156.6 48.0 78.8 57.7 125.8 72.3 108.6 85.6 31.2 60.8 77.3 41.2 35.5 104.4 49.2 62.5 158.1 50.6 51.1 60.2 72.6 60.1 86.2 91.5 78.0 73.0 104.2 41.3 56.7 162.8 51.7 97.9 75.6 11.4 8.1 4.1 8.7 6.8 11.0 13.1 10.8 9.2 6.5 16.7 11.2 10.3 7.7 12.8 13.7 15.3 8.3 2.9 8.6 10.7 9.8 11.9 10.6 9.3 10.4 10.0 9.8 10.6 9.6 14.3 73.4 38.5 36.1 56.8 67.9 38.4 48.3 59.7 77.4 103.4 63.1 64.0 82.1 22.8 44.1 42.3 125.1 61.1 81.9 17.5 17.6 41.9 29.0 66.0 166.5 59.7 25.8 147.6 85.5 36.0 60.6 73.2 55.0 72.6 45.6 105.1 32.5 41.2 35.9 104.3 77.1 31.2 38.7 45.5 20.1 15.5 56.8 54.6 19.6 61.8 63.6 73.1 57.7 82.0 76.0 34.9 16.6 69.6 69.3 57.1 13.2 23.5 50.1 111.6 52.6 91.2 69.3 100.7 106.3 85.3 40.6 33.0 71.0 143.2 55.2 36.4 PRKG1 "PGK, PKG, PKG1, PRKG1B, PRKGR1B" ENSG00000185532 "Protein kinase cGMP-dependent 1" Q13976 10 50990888-52298423 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Allosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase" "Aortic aneurysm, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "tongue: 36.1" "Cell type enhanced" "Detected in many" "Astrocytes: 778.3;Excitatory neurons: 244.9;Inhibitory neurons: 473.0;Microglial cells: 188.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 36 "basophil: 7.3" "Lineage enriched" "Detected in single" 49 "granulocytes: 7.3" "Cell line enhanced" "Detected in many" "AN3-CA: 14.3;BJ hTERT+: 19.2;fHDF/TERT166: 16.1;U-138 MG: 11.2;U-87 MG: 10.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007699, CAB009629" Enhanced Approved Vesicles,Cytosol NA NA "Cluster 34: Basophils - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Vesicles, Cytosol" "CAB009629: AB_2170663, HPA007699: AB_1079677" "unprognostic (3.94e-2)" "unprognostic (2.60e-1)" "unprognostic (1.44e-2)" "unprognostic (5.36e-2)" "unprognostic (1.25e-1)" "unprognostic (1.86e-1)" "unprognostic (5.54e-1)" "unprognostic (2.23e-1)" "unprognostic (4.94e-1)" "unprognostic (2.05e-2)" "unprognostic (1.22e-2)" "unprognostic (3.40e-1)" "unprognostic (9.26e-2)" "unprognostic (5.50e-3)" "unprognostic (4.24e-2)" "unprognostic (1.11e-1)" "unprognostic (3.78e-4)" 7.0 8.3 6.4 2.7 7.2 0.6 3.1 1.4 6.9 10.3 12.4 5.5 2.4 10.3 3.5 5.2 5.2 7.0 14.1 6.6 10.7 3.8 1.7 6.8 1.2 5.1 4.6 4.2 1.7 9.6 1.3 10.1 3.2 6.4 5.3 3.6 4.0 8.1 25.8 1.0 3.4 14.6 5.3 2.5 3.3 1.8 12.2 1.5 7.0 36.1 0.9 5.4 4.2 2.7 0.1 0.2 1.7 14.3 6.5 6.0 0.1 5.4 19.2 2.1 2.6 0.1 0.9 0.3 0.0 16.1 2.0 0.1 0.0 0.1 1.7 0.0 5.0 1.0 0.3 0.0 5.5 0.0 0.1 8.1 0.1 4.8 0.1 0.6 0.0 0.0 0.0 0.1 5.3 0.1 0.0 0.0 4.1 0.0 2.5 0.0 3.9 0.0 0.0 0.0 0.0 7.1 0.0 0.0 0.1 2.0 0.1 0.0 0.0 11.2 1.9 5.9 3.7 1.5 0.8 0.0 10.0 0.0 2.5 7.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 6.4 7.2 1.4 6.9 6.6 10.7 5.1 4.6 3.2 5.3 12.2 2.7 10.5 16.0 10.8 778.3 0.3 0.9 1.7 0.0 7.4 5.9 2.8 9.4 31.4 0.0 0.0 3.7 0.0 1.0 0.3 2.9 0.0 2.4 56.0 0.4 14.7 7.1 0.0 3.4 244.9 3.6 1.2 24.2 0.5 0.5 4.5 0.1 5.0 0.0 0.4 0.0 473.0 4.2 0.0 0.0 2.2 53.0 32.6 5.3 3.6 188.3 0.0 23.6 0.0 24.6 8.0 4.8 14.1 39.5 0.1 0.5 3.2 0.2 0.9 1.3 39.5 3.9 69.9 0.9 0.9 1.6 0.6 2.2 0.2 7.9 3.6 1.0 PRKG2 "cGKII, PKG2, PRKGR2" ENSG00000138669 "Protein kinase cGMP-dependent 2" Q13237 4 81087370-81215117 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 13.1;prostate: 9.6" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 35.3;Excitatory neurons: 32.6;Inhibitory neurons: 66.1;Oligodendrocyte precursor cells: 106.6;Proximal enterocytes: 19.7;Smooth muscle cells: 29.8" "Group enriched" "Detected in some" 4 "melanoma: 4.1;prostate cancer: 2.3" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC diff: 5.0;ASC TERT1: 3.8;HEL: 21.2;hTCEpi: 4.0;SCLC-21H: 6.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA007386, CAB018739" Approved NA NA "Cluster 46: Basophils - DNA binding" "Cluster 56: Intestine - Transmembrane transport" "Cluster 36: HEL - Hemostasis" "Cluster 10: Non-specific - Unknown function" "CAB018739: AB_2284387, HPA007386: AB_1079678" "unprognostic (6.14e-2)" "unprognostic (2.77e-1)" "unprognostic (2.14e-1)" "unprognostic (5.01e-4)" "unprognostic (4.33e-2)" "unprognostic (6.85e-2)" "unprognostic (1.13e-1)" "unprognostic (5.57e-2)" "unprognostic (2.05e-1)" "unprognostic (1.86e-1)" "unprognostic (4.70e-2)" "unprognostic (1.48e-1)" "unprognostic (8.27e-2)" "unprognostic (2.33e-1)" "unprognostic (1.58e-1)" "unprognostic (4.00e-3)" "unprognostic (1.06e-1)" 1.0 0.2 2.1 0.2 1.5 0.5 1.5 0.5 1.7 1.0 0.0 2.4 9.6 0.4 0.3 2.8 0.3 0.2 4.3 1.5 1.6 0.5 0.0 3.3 0.2 3.5 2.7 0.0 1.4 0.0 2.2 0.0 3.8 9.6 2.8 0.3 0.3 3.4 0.0 1.2 13.1 0.5 2.2 0.0 0.9 0.9 6.0 1.0 0.9 0.0 0.4 0.5 0.6 1.0 0.1 0.3 0.1 0.0 5.0 3.8 0.0 0.3 0.0 0.0 0.0 0.4 2.4 0.0 0.2 0.9 0.0 0.1 0.3 1.5 0.0 0.4 0.0 21.2 0.6 0.1 0.0 0.0 0.0 0.5 4.0 0.0 0.0 1.0 0.0 0.6 0.0 0.6 0.0 0.0 0.0 0.1 0.9 0.6 0.4 0.0 0.0 0.1 0.0 0.9 6.3 0.0 0.0 0.2 0.0 0.3 0.5 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 2.1 1.5 0.5 1.7 1.5 1.6 3.5 2.7 3.8 2.2 6.0 1.0 0.3 35.3 2.6 1.0 0.3 0.0 0.9 0.1 1.2 0.0 0.3 0.1 4.9 0.0 2.0 0.0 0.0 0.0 0.1 5.5 0.0 0.2 10.3 0.3 0.6 0.1 0.0 8.0 32.6 0.0 0.1 2.5 0.0 0.1 1.3 0.1 0.0 0.0 0.1 0.0 66.1 1.7 0.0 0.0 0.0 2.2 0.0 0.1 0.0 12.2 0.1 0.0 0.0 106.6 1.1 0.9 9.2 0.0 0.5 0.8 19.7 0.2 0.8 0.0 0.0 0.1 29.8 0.0 1.3 0.8 0.1 0.0 0.4 0.0 0.7 0.3 PRKN "AR-JP, PARK2, parkin, PDJ" ENSG00000185345 "Parkin RBR E3 ubiquitin protein ligase" O60260 6 161347417-162727775 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, Transcription, Transcription regulation, Ubl conjugation pathway" Transferase "Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 28.3;tongue: 15.9" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 9.6;Alveolar cells type 2: 4.8;Distal tubular cells: 19.6;Proximal tubular cells: 6.8" "Cancer enhanced" "Detected in many" "renal cancer: 3.3" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "AN3-CA: 2.0;HEL: 4.1;HSkMC: 1.7;Karpas-707: 2.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB016257, HPA036012" Enhanced Supported "Nuclear speckles,Cytosol" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 36: HEL - Hemostasis" "Cluster 39: Non-specific - Basic cellular processes" "Nuclear speckles" Cytosol "CAB016257: AB_628104, HPA036012: AB_2732471" "unprognostic (9.23e-2)" "unprognostic (3.29e-2)" "unprognostic (6.48e-2)" "unprognostic (2.69e-3)" "unprognostic (9.85e-2)" "unprognostic (5.85e-2)" "unprognostic (7.07e-2)" "unprognostic (1.12e-1)" "unprognostic (1.39e-1)" "unprognostic (2.68e-2)" "unprognostic (1.03e-3)" "unprognostic (8.16e-2)" "prognostic favorable (6.75e-12)" "unprognostic (9.93e-2)" "unprognostic (1.51e-1)" "unprognostic (5.24e-2)" "unprognostic (2.50e-1)" 3.4 3.3 4.1 0.1 3.6 0.3 1.9 0.4 5.7 1.3 0.6 2.7 1.2 1.6 1.2 3.2 1.2 1.5 9.1 4.6 1.8 5.2 1.2 1.0 0.5 1.0 1.9 2.8 1.2 2.3 1.8 0.4 1.6 1.2 0.6 1.5 1.3 1.4 28.3 2.0 1.0 1.2 1.0 1.0 1.9 5.3 1.9 0.5 1.3 15.9 0.3 2.5 1.0 2.4 0.0 0.0 0.3 2.0 0.4 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.5 0.0 0.3 0.0 0.1 0.0 0.0 0.1 0.5 4.1 0.1 0.6 0.3 0.0 0.0 1.7 0.0 0.0 0.2 0.3 0.0 0.2 0.2 2.2 0.0 0.2 0.0 0.0 0.0 0.2 0.8 0.0 0.0 0.7 0.0 0.0 0.5 1.0 0.0 0.2 0.2 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.7 1.7 0.3 2.2 0.8 0.1 1.3 0.6 0.8 0.9 0.7 1.6 1.8 1.8 0.5 0.6 0.4 0.0 0.1 0.8 4.1 3.6 0.4 5.7 4.6 1.8 1.0 1.9 1.6 1.0 1.9 2.4 2.3 9.6 4.8 0.0 0.6 0.0 0.0 0.0 0.0 0.0 2.1 1.5 0.0 0.0 1.8 1.8 0.0 0.5 0.4 0.0 19.6 1.1 0.0 3.4 1.8 0.7 0.0 0.0 0.0 2.2 0.1 1.8 0.0 3.2 2.5 3.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 6.8 1.5 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.3 0.4 3.7 0.0 0.0 PRKX PKX1 ENSG00000183943 "Protein kinase X-linked" P51817 X 3604340-3713649 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Angiogenesis, Differentiation" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "thyroid gland: 33.8" "Cell type enhanced" "Detected in many" "dendritic cells: 108.3;Endometrial ciliated cells: 164.0;Glandular and luminal cells: 179.5;NK-cells: 139.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 11.0" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HMC-1: 74.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015324 Supported Supported Nucleoplasm No No "Cluster 41: Basophils - Cellular respiration" "Cluster 21: Non-specific - Transcription" "Cluster 3: HMC-1 - Innate immune response" "Cluster 44: Endometrium - Transcription" Nucleoplasm "HPA015324: AB_1855715" "unprognostic (1.07e-1)" "unprognostic (1.23e-2)" "unprognostic (1.57e-1)" "unprognostic (3.63e-1)" "unprognostic (2.45e-1)" "unprognostic (3.33e-2)" "unprognostic (1.47e-1)" "unprognostic (1.33e-2)" "unprognostic (4.14e-1)" "unprognostic (1.68e-1)" "unprognostic (2.68e-1)" "unprognostic (2.92e-1)" "unprognostic (1.07e-3)" "unprognostic (2.15e-2)" "unprognostic (9.91e-2)" "unprognostic (2.52e-1)" "unprognostic (1.70e-2)" 5.5 1.6 10.0 9.8 12.9 7.7 7.9 12.6 8.8 7.8 12.7 6.5 5.1 4.6 9.6 13.9 19.4 4.4 3.7 8.3 14.3 15.6 1.8 9.0 12.8 18.1 13.8 4.0 4.4 3.1 2.0 5.3 15.8 3.8 6.1 1.7 6.1 5.9 2.2 12.0 6.3 3.7 14.5 12.4 4.0 6.8 15.3 15.4 33.8 3.2 9.9 4.5 12.4 17.1 9.1 8.3 22.4 16.7 4.2 5.6 20.5 5.3 2.1 2.6 3.5 12.4 6.1 0.7 5.3 4.3 5.4 6.2 21.1 16.1 4.5 10.2 14.7 10.0 6.7 0.2 4.4 13.0 74.7 3.8 16.8 2.8 10.3 7.1 25.7 12.3 11.8 12.7 8.6 8.0 15.0 11.7 15.0 7.0 9.4 27.7 21.5 17.2 20.6 7.6 14.9 9.6 5.6 3.6 5.5 35.1 2.8 10.3 14.2 2.2 3.8 3.7 3.6 0.3 0.7 11.6 1.3 11.6 5.8 11.0 2.0 1.2 2.3 2.4 2.4 1.6 2.4 2.2 1.6 1.5 1.9 2.1 0.5 2.4 3.2 1.9 1.8 1.2 10.0 12.9 12.6 8.8 8.3 14.3 18.1 13.8 15.8 14.5 15.3 17.1 32.0 3.2 9.4 7.8 35.5 21.4 22.3 9.7 21.6 1.8 14.4 9.1 1.6 30.0 10.1 5.5 0.0 30.8 108.3 8.8 13.7 10.8 11.9 164.0 23.8 19.7 4.8 7.2 1.3 3.1 5.8 10.4 6.1 179.5 85.1 11.8 13.2 2.3 16.9 1.7 20.2 13.5 24.4 19.4 24.1 49.2 19.9 29.0 5.4 39.4 53.4 2.2 139.0 11.1 7.0 5.6 13.1 21.8 38.2 29.0 10.7 6.1 18.0 0.6 32.9 46.4 12.4 1.3 21.6 34.1 26.9 7.8 63.5 10.6 23.6 20.4 PRPF4B "KIAA0536, PR4H, Prp4" ENSG00000112739 "Pre-mRNA processing factor 4B" Q13523 6 4021267-4064983 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "mRNA processing, mRNA splicing" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA020638 Approved Supported "Nuclear speckles" NA NA "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 20: HeLa - Mitochondria" "Cluster 52: Non-specific - Transcription" "Nuclear speckles" "HPA020638: AB_1855774" "unprognostic (1.03e-1)" "unprognostic (2.66e-1)" "unprognostic (4.95e-2)" "unprognostic (2.20e-1)" "unprognostic (3.59e-3)" "unprognostic (1.21e-2)" "prognostic unfavorable (2.27e-4)" "unprognostic (8.68e-3)" "unprognostic (3.41e-2)" "unprognostic (4.45e-3)" "unprognostic (2.17e-1)" "unprognostic (1.07e-1)" "unprognostic (9.50e-3)" "unprognostic (8.90e-2)" "unprognostic (2.34e-1)" "unprognostic (7.63e-3)" "prognostic favorable (6.82e-5)" 9.1 7.2 4.8 11.3 5.4 27.3 8.1 7.5 6.7 5.8 5.2 8.6 10.2 9.9 10.1 8.4 4.4 6.1 5.0 4.7 5.1 4.2 4.3 6.8 14.2 5.4 5.5 8.4 6.8 4.2 3.3 7.6 5.3 6.3 8.6 15.9 8.4 5.5 16.3 13.3 9.0 5.6 4.9 11.2 8.1 3.8 5.5 8.8 6.5 4.5 10.0 6.7 7.0 6.9 6.0 3.9 14.4 12.1 8.3 7.3 12.3 7.7 3.4 4.7 5.2 6.9 7.1 8.1 5.7 5.1 4.8 12.8 10.1 6.8 7.1 4.4 11.1 6.7 19.1 11.5 3.6 11.2 10.6 5.7 6.9 5.4 6.6 11.0 5.1 6.5 11.6 3.1 7.4 2.7 7.2 26.3 6.0 3.8 4.3 9.9 6.1 11.2 8.4 10.2 7.9 7.3 4.7 3.9 5.5 16.9 9.6 7.9 7.3 11.2 6.5 4.3 8.2 7.5 7.9 6.9 3.2 7.6 7.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.8 5.4 7.5 6.7 4.7 5.1 5.4 5.5 5.3 4.9 5.5 6.9 122.4 109.0 103.2 35.6 110.5 83.5 64.0 43.1 69.4 88.6 80.4 49.5 79.1 61.5 75.1 97.5 89.6 61.8 151.3 94.9 72.4 64.4 15.6 115.9 143.5 85.8 75.3 79.1 42.8 56.8 49.9 78.7 88.2 113.4 90.5 96.2 61.1 85.8 41.1 106.0 49.8 88.8 50.8 71.6 49.4 20.6 98.8 71.4 35.6 49.6 97.4 81.2 118.4 50.8 68.1 62.8 61.5 89.1 101.9 62.8 55.5 89.5 71.7 184.0 59.2 105.3 85.8 66.1 76.5 66.7 91.4 63.6 106.2 93.1 87.7 65.2 PRRT2 "DKFZp547J199, DSPB3, DYT10, EKD1, FICCA, FLJ25513, ICCA, IFITMD1, PKC" ENSG00000167371 "Proline rich transmembrane protein 2" Q7Z6L0 16 29811382-29815892 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Disease variant, Dystonia, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "ovary: 124.3" "Cell type enhanced" "Detected in many" "Bipolar cells: 82.3;Cone photoreceptor cells: 31.3;Leydig cells: 36.1;Peritubular cells: 40.3;Rod photoreceptor cells: 37.1" "Cancer enhanced" "Detected in many" "glioma: 5.8" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 7 "NK-cell: 3.2" "Lineage enriched" "Detected in single" 7 "NK-cells: 3.2" "Cell line enhanced" "Detected in many" "AF22: 24.1;HeLa: 13.8;hTERT-RPE1: 14.0;REH: 17.6;U-138 MG: 14.5" "HPA014447, HPA019203, HPA048045" Enhanced Supported "Plasma membrane" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 35: Non-specific - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 56: Bipolar cells - Visual perception" "Plasma membrane" "HPA014447: AB_1855786, HPA019203: AB_2670097, HPA048045: " "unprognostic (7.60e-3)" "unprognostic (3.00e-1)" "unprognostic (8.32e-3)" "unprognostic (4.34e-2)" "unprognostic (3.72e-2)" "unprognostic (1.19e-3)" "unprognostic (2.85e-1)" "unprognostic (1.23e-1)" "unprognostic (9.30e-2)" "unprognostic (1.93e-1)" "unprognostic (4.45e-2)" "unprognostic (3.26e-2)" "unprognostic (3.43e-8)" "unprognostic (1.22e-1)" "unprognostic (1.17e-1)" "unprognostic (5.12e-2)" "unprognostic (2.44e-2)" 13.4 10.5 32.9 2.4 40.4 0.3 10.8 70.7 70.5 79.4 0.0 33.9 5.3 39.5 8.6 6.7 47.0 10.9 15.6 46.0 20.1 8.7 2.4 12.9 3.3 15.6 8.0 124.3 4.7 4.3 85.6 7.0 16.2 39.1 2.3 19.8 5.4 13.9 4.5 5.0 14.5 10.4 24.5 1.7 12.4 14.6 29.2 0.5 10.6 1.8 1.0 34.1 51.0 34.0 0.1 1.5 24.1 8.6 1.2 4.2 0.5 2.5 4.1 1.0 0.8 1.1 1.5 0.2 0.3 4.4 0.5 1.6 3.4 0.2 0.4 4.1 1.4 1.7 13.8 1.6 0.3 0.0 0.3 4.1 0.1 1.9 0.1 14.0 1.0 0.7 0.2 1.5 0.2 3.1 0.6 0.5 5.0 0.1 1.1 17.6 0.9 0.4 0.2 0.8 4.1 4.3 0.2 2.1 0.5 3.5 7.6 0.0 1.3 14.5 5.2 0.7 1.4 3.7 0.5 0.2 5.3 0.2 0.5 0.4 0.0 0.1 0.0 0.0 0.1 0.0 0.2 0.1 0.0 0.0 0.1 0.1 0.1 3.2 0.1 0.0 0.0 0.1 32.9 40.4 70.7 70.5 46.0 20.1 15.6 8.0 16.2 24.5 29.2 34.0 2.3 3.2 0.0 22.9 0.9 1.1 1.4 1.7 0.6 82.3 1.6 1.7 0.8 1.5 1.2 0.0 31.3 1.9 1.9 9.5 1.9 1.1 2.0 4.4 10.4 5.0 6.1 0.0 24.4 1.5 0.8 11.4 2.0 1.6 0.0 1.7 3.3 0.1 0.4 20.2 19.5 4.2 2.0 0.0 2.4 9.8 36.1 0.5 0.0 5.6 0.6 5.7 1.0 8.5 1.6 3.0 9.0 40.3 0.7 1.8 15.2 1.0 5.6 37.1 6.6 2.9 11.7 2.4 3.1 0.4 0.4 2.6 2.7 0.6 2.5 1.3 PSKH1 ENSG00000159792 "Protein serine kinase H1" P11801 16 67893254-67929676 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA053927, HPA062763" Approved Supported "Nuclear speckles,Cytosol" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 29: Non-specific - Vesicular transport" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 40: Granulosa cells - Unknown function" "Nuclear speckles, Cytosol" "HPA053927: AB_2682312, HPA062763: " "unprognostic (2.57e-2)" "unprognostic (8.91e-3)" "unprognostic (1.88e-1)" "unprognostic (5.79e-2)" "unprognostic (3.26e-1)" "unprognostic (3.89e-1)" "unprognostic (1.64e-1)" "unprognostic (1.29e-2)" "unprognostic (3.03e-1)" "unprognostic (1.66e-2)" "unprognostic (9.85e-3)" "unprognostic (8.32e-2)" "prognostic favorable (4.28e-10)" "unprognostic (1.46e-1)" "unprognostic (1.99e-1)" "unprognostic (4.15e-2)" "unprognostic (3.90e-3)" 14.3 18.6 12.8 9.6 14.5 5.2 14.0 12.2 13.5 13.5 19.5 18.2 13.7 19.3 10.0 16.9 18.7 10.1 17.6 11.2 11.5 20.5 16.5 12.7 10.6 15.0 14.9 19.4 26.3 32.9 13.2 7.6 13.4 15.1 10.8 4.0 18.1 12.7 15.3 13.8 15.7 15.7 13.2 12.8 21.4 21.8 13.6 12.0 15.0 13.5 8.5 16.5 9.5 14.9 13.0 22.7 25.2 28.1 38.4 19.3 16.3 15.2 23.0 15.8 14.0 17.2 18.2 12.2 22.7 25.7 12.7 19.2 14.7 15.6 5.3 4.8 16.4 13.9 16.8 22.0 26.3 13.4 8.0 35.7 26.7 18.8 19.6 21.3 23.3 22.5 21.6 5.1 16.7 28.7 18.3 8.6 24.2 14.0 13.9 27.7 9.7 25.3 18.6 16.0 21.8 26.0 47.3 12.8 15.8 9.9 23.5 23.9 20.8 17.7 6.2 15.0 7.7 15.3 8.7 26.2 21.4 8.8 19.9 0.0 2.0 1.9 2.0 2.2 1.4 1.5 1.5 2.0 2.1 1.2 1.2 1.7 1.0 2.1 1.5 1.5 0.8 1.7 12.8 14.5 12.2 13.5 11.2 11.5 15.0 14.9 13.4 13.2 13.6 14.9 5.5 0.0 3.6 4.6 2.9 1.1 3.1 5.2 2.2 11.1 5.3 4.6 2.3 7.2 3.8 5.5 6.2 6.2 3.0 11.5 11.7 6.0 14.4 5.8 6.5 5.2 10.8 3.0 4.6 7.4 4.8 5.4 5.1 4.8 6.3 13.0 5.3 10.3 4.8 6.7 6.1 6.2 10.2 6.3 1.6 22.1 4.7 2.9 5.4 3.7 4.8 11.0 3.1 5.5 9.2 7.6 4.5 7.9 3.0 3.6 10.0 8.1 4.9 6.9 13.1 6.3 6.1 6.7 6.1 5.4 1.6 5.9 3.8 10.7 7.4 2.2 PSKH2 ENSG00000147613 "Protein serine kinase H2" Q96QS6 8 86047109-86088621 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 10 "retina: 2.4" "Cell type enhanced" "Detected in single" "Rod photoreceptor cells: 2.1" "Cancer enriched" "Detected in single" 5 "testis cancer: 0.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 12 "HEL: 9.4" "HPA015095, HPA056839" Approved Approved "Nucleoplasm,Nuclear bodies,Cytosol" NA NA "Cluster 77: Retina - Visual perception" "Cluster 36: HEL - Hemostasis" "Cluster 46: Photoreceptor cells - Phototransduction" Nucleoplasm "Nuclear bodies, Cytosol" "HPA015095: AB_1855815, HPA056839: " "unprognostic (1.77e-2)" 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 PTPMT1 "DUSP23, MOSP, PLIP" ENSG00000110536 "Protein tyrosine phosphatase mitochondrial 1" Q8WUK0 11 47565430-47573461 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 235.1;Late spermatids: 640.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043932, HPA060060" Approved Enhanced Mitochondria NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 71: Testis - DNA repair" "Cluster 6: T47d - Mammary gland" "Cluster 25: Spermatids - Spermatogenesis" Mitochondria "HPA043932: AB_2678738, HPA060060: " "unprognostic (6.61e-2)" "unprognostic (2.09e-1)" "unprognostic (1.28e-1)" "unprognostic (2.37e-3)" "unprognostic (1.02e-1)" "unprognostic (1.26e-2)" "prognostic unfavorable (3.04e-5)" "unprognostic (3.29e-2)" "unprognostic (2.77e-2)" "unprognostic (1.93e-3)" "unprognostic (6.76e-2)" "unprognostic (1.72e-1)" "unprognostic (2.68e-3)" "unprognostic (1.21e-1)" "unprognostic (5.39e-1)" "unprognostic (2.17e-2)" "unprognostic (1.75e-1)" 38.8 56.5 15.0 5.3 16.1 9.0 37.4 15.8 17.4 31.1 16.6 31.0 7.6 32.8 7.8 34.8 29.5 4.2 27.7 14.4 16.5 37.6 40.6 36.5 6.1 15.6 16.3 28.0 44.7 9.6 41.9 6.7 15.8 32.7 3.9 4.2 37.1 5.9 41.0 28.1 23.4 4.7 16.0 28.9 39.2 105.4 17.0 4.3 30.6 5.8 4.9 27.5 28.1 16.0 34.5 19.4 2.3 17.8 17.5 11.4 7.0 20.1 17.1 19.4 16.8 27.9 17.6 27.9 22.1 14.7 16.8 30.6 16.9 20.4 16.6 31.4 57.3 12.9 43.8 43.4 25.7 25.2 17.1 12.7 21.9 8.8 24.0 11.2 13.7 26.2 32.6 19.5 14.2 65.4 21.4 41.0 18.8 3.9 37.7 38.6 16.7 22.3 22.5 23.3 15.5 21.4 33.8 11.1 23.2 7.2 53.1 32.7 16.6 13.6 23.3 28.6 33.1 27.1 22.6 18.6 13.6 23.3 10.0 11.2 38.0 38.2 24.8 36.8 23.0 33.7 22.7 26.2 44.9 30.3 22.3 21.0 3.1 26.1 34.6 64.6 28.5 28.8 15.0 16.1 15.8 17.4 14.4 16.5 15.6 16.3 15.8 16.0 17.0 16.0 26.8 22.4 35.0 14.4 31.8 17.8 15.8 58.5 34.1 14.4 64.9 78.4 5.8 45.8 38.6 40.5 4.2 72.2 34.7 19.9 72.4 95.3 235.1 48.0 23.9 24.6 31.3 30.1 8.2 85.8 66.3 23.9 28.1 25.6 17.1 16.5 29.6 39.8 62.4 5.0 10.8 45.7 48.8 32.6 21.2 640.8 46.6 45.6 46.2 6.5 56.2 74.9 41.2 9.5 14.6 106.2 38.8 46.6 61.0 26.0 37.9 72.8 57.2 15.7 19.7 17.3 28.1 179.8 28.6 55.0 17.3 76.8 25.9 21.3 62.7 22.0 PTRH1 "C9orf115, PTH1" ENSG00000187024 "Peptidyl-tRNA hydrolase 1 homolog" Q86Y79 9 127690348-127724873 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Proximal tubular cells: 125.4;Theca cells: 460.9" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "PC-3: 52.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021223 Uncertain NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 18: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 52: Non-specific - Transcription" "HPA021223: AB_1845798" "unprognostic (6.58e-2)" "unprognostic (7.01e-3)" "unprognostic (3.46e-3)" "unprognostic (2.53e-2)" "unprognostic (7.05e-2)" "unprognostic (1.30e-1)" "unprognostic (2.44e-1)" "unprognostic (3.90e-2)" "unprognostic (1.74e-1)" "unprognostic (6.58e-3)" "unprognostic (8.67e-2)" "unprognostic (4.08e-2)" "unprognostic (5.98e-3)" "unprognostic (5.74e-4)" "unprognostic (1.38e-2)" "unprognostic (1.91e-1)" "unprognostic (1.72e-2)" 16.6 25.5 9.0 5.0 9.1 4.3 15.7 8.0 13.7 11.9 6.8 12.1 4.3 12.7 9.5 10.4 15.1 3.8 18.3 9.1 7.8 26.7 18.1 12.7 3.3 6.7 6.9 8.3 20.9 7.7 17.7 2.7 6.8 13.6 2.3 2.8 11.5 5.3 19.9 24.8 7.6 3.5 6.0 12.6 14.5 17.4 8.2 4.1 20.1 3.3 2.5 12.9 9.6 8.3 28.4 11.7 2.2 7.5 3.9 5.1 20.3 18.6 5.0 7.0 3.9 5.2 10.1 9.4 24.3 8.0 9.2 31.0 2.4 13.3 2.5 15.4 3.5 4.0 15.4 11.8 11.2 6.3 12.0 4.2 13.1 8.6 8.9 3.5 13.4 14.2 11.8 8.2 7.8 24.4 12.7 7.9 3.5 23.5 52.9 10.0 5.5 22.9 13.2 5.6 11.9 10.7 18.7 23.0 14.4 2.0 20.3 3.0 15.8 9.2 13.9 36.0 11.1 23.5 14.1 7.1 13.2 4.2 11.8 8.5 31.1 14.0 67.5 37.2 69.3 21.7 34.3 68.5 28.0 17.1 24.8 57.0 4.0 28.1 20.1 25.3 37.2 31.6 9.0 9.1 8.0 13.7 9.1 7.8 6.7 6.9 6.8 6.0 8.2 8.3 17.4 3.2 9.1 2.0 8.6 17.0 41.2 27.4 9.1 28.3 26.5 23.1 0.3 21.5 13.8 47.8 45.9 13.1 13.4 11.2 66.5 60.5 86.6 54.9 25.2 19.7 30.1 10.8 1.3 33.6 23.7 20.1 10.7 25.5 17.2 15.8 18.5 28.1 46.6 16.8 1.0 25.8 32.6 11.3 13.9 18.7 22.1 11.6 16.0 1.0 15.4 22.2 22.6 2.0 1.0 48.1 13.4 94.0 8.8 85.3 14.6 125.4 43.8 59.0 0.0 15.2 17.0 24.6 9.2 14.4 21.2 18.7 16.0 460.9 17.5 34.8 PTRH2 "BIT1, CFAP37, CGI-147, PTH2" ENSG00000141378 "Peptidyl-tRNA hydrolase 2" Q9Y3E5 17 59674636-59707626 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" Apoptosis Hydrolase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA012897 Supported Supported Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 68: Epididymis - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Mitochondria "HPA012897: AB_1855949" "unprognostic (2.26e-1)" "unprognostic (2.80e-2)" "unprognostic (1.02e-2)" "unprognostic (3.89e-2)" "unprognostic (1.31e-2)" "unprognostic (3.38e-2)" "prognostic unfavorable (1.50e-4)" "unprognostic (6.38e-2)" "unprognostic (2.02e-1)" "unprognostic (9.59e-3)" "unprognostic (2.72e-1)" "unprognostic (1.40e-1)" "prognostic unfavorable (1.01e-8)" "unprognostic (5.43e-3)" "unprognostic (6.82e-2)" "unprognostic (1.32e-1)" "unprognostic (1.49e-2)" 20.8 25.9 24.3 17.3 25.1 14.5 27.6 25.0 31.9 19.7 23.6 24.1 15.3 18.8 48.5 18.1 18.4 18.2 14.5 25.1 26.1 18.5 45.7 14.7 19.0 25.9 26.1 16.9 19.5 18.6 14.1 18.6 26.7 20.7 27.5 10.2 15.9 18.6 25.0 15.7 13.2 22.9 24.8 17.5 16.1 19.5 24.9 17.3 16.2 20.9 24.1 44.0 11.8 27.4 75.9 142.9 44.3 40.8 84.8 72.6 47.4 70.6 63.8 60.7 89.0 94.1 57.7 54.1 105.0 60.9 101.1 73.3 98.4 93.8 89.4 104.2 133.2 96.7 72.3 176.2 129.4 86.0 52.5 82.0 120.9 93.9 108.5 42.8 102.5 37.4 111.3 58.2 92.4 187.9 74.2 71.2 38.0 194.5 113.4 39.1 74.8 80.7 103.7 109.2 57.9 74.2 36.7 39.6 91.5 50.7 93.1 61.1 67.2 77.8 77.8 47.1 77.9 73.6 91.9 82.3 50.7 54.4 60.4 6.1 69.0 2.9 22.7 67.4 30.9 43.1 26.3 25.7 50.0 33.1 37.4 27.0 29.0 34.8 86.0 59.4 34.0 37.9 24.3 25.1 25.0 31.9 25.1 26.1 25.9 26.1 26.7 24.8 24.9 27.4 21.4 16.0 13.6 5.5 18.7 36.7 50.1 48.1 27.9 4.1 17.1 22.4 15.4 11.5 51.6 11.0 4.2 26.8 13.0 8.9 11.7 27.2 22.1 23.4 33.1 22.5 6.7 17.9 9.8 25.6 25.0 29.7 17.3 24.1 22.8 12.8 12.8 31.5 16.9 8.4 9.1 10.3 22.4 9.7 17.2 12.0 17.4 14.6 14.2 2.8 11.4 7.2 13.4 7.5 11.5 28.8 12.3 9.8 24.8 35.1 10.0 16.5 33.3 3.4 13.1 25.4 32.2 33.4 13.3 21.3 35.7 31.7 12.6 22.4 16.7 37.5 PUS1 ENSG00000177192 "Pseudouridine synthase 1" Q9Y606 12 131929200-131945896 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "tRNA processing" Isomerase "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA051636, HPA057593" Approved Supported Nucleoplasm,Mitochondria NA NA "Cluster 15: NK-cells - Transcription" "Cluster 18: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Mitochondria" "HPA051636: AB_2681560, HPA057593: AB_2683479" "unprognostic (2.72e-1)" "unprognostic (9.13e-2)" "unprognostic (1.81e-1)" "unprognostic (2.69e-2)" "unprognostic (8.12e-3)" "unprognostic (8.07e-2)" "unprognostic (4.57e-3)" "unprognostic (7.34e-2)" "unprognostic (1.01e-1)" "unprognostic (3.34e-1)" "unprognostic (2.06e-1)" "unprognostic (5.30e-2)" "prognostic unfavorable (3.49e-8)" "unprognostic (1.80e-3)" "unprognostic (8.06e-2)" "unprognostic (8.59e-2)" "unprognostic (1.56e-2)" 12.5 14.9 10.1 14.9 8.4 23.0 10.4 8.2 10.2 9.7 7.6 11.9 9.7 12.5 14.0 16.5 11.2 7.1 8.7 8.9 5.9 13.0 21.6 9.0 18.5 7.1 5.1 8.6 14.8 5.4 8.7 6.4 6.2 10.9 7.9 5.0 9.3 6.8 14.2 14.4 14.0 7.4 4.4 15.8 12.7 13.0 6.9 8.6 9.5 4.8 10.6 14.2 10.7 9.2 45.3 58.1 13.7 24.0 13.0 21.5 82.2 34.5 14.2 25.4 16.3 64.5 28.7 53.2 38.3 18.6 19.9 56.0 44.4 32.2 16.3 24.0 90.6 54.0 30.9 56.9 34.0 93.5 47.4 21.7 25.6 28.9 24.8 12.3 25.0 36.8 68.0 15.6 14.9 77.9 61.9 83.4 71.5 36.7 87.3 57.8 19.2 55.4 20.8 61.7 37.5 20.8 28.6 38.9 32.5 13.1 42.5 99.3 22.7 20.2 43.3 43.1 50.0 43.5 35.5 64.5 20.7 73.6 28.4 1.0 1.3 0.2 2.0 1.0 1.5 4.6 1.7 2.1 1.1 4.2 2.4 1.3 1.1 5.6 0.9 3.0 1.8 0.9 10.1 8.4 8.2 10.2 8.9 5.9 7.1 5.1 6.2 4.4 6.9 9.2 7.0 0.0 6.1 9.8 10.7 29.6 22.3 8.4 6.2 6.2 10.7 10.5 5.3 8.6 6.2 5.5 22.9 13.9 11.7 10.9 5.9 12.3 0.9 6.6 10.1 11.1 14.4 13.2 11.9 9.6 19.1 8.3 15.3 7.7 16.5 11.7 6.1 12.9 15.2 0.0 8.4 20.1 10.2 7.3 8.1 3.0 7.8 7.2 7.2 9.4 8.8 4.4 6.2 5.0 7.1 16.3 6.9 9.4 8.8 35.4 4.0 13.7 4.9 10.0 6.6 15.9 9.3 18.5 19.7 14.7 22.7 8.6 9.5 14.3 18.8 21.4 QPCT "GCT, QC" ENSG00000115828 "Glutaminyl-peptide cyclotransferase" Q16769 2 37342827-37373322 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 170.3;epididymis: 104.0" "Group enriched" "Detected in many" 4 "Enteroendocrine cells: 217.0;Ionocytes: 138.4;Langerhans cells: 163.4;Melanocytes: 528.3" "Cancer enhanced" "Detected in all" "melanoma: 97.4" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 4 "neutrophil: 1527.7" "Lineage enriched" "Detected in many" 4 "granulocytes: 1527.7" "Cell line enhanced" "Detected in many" "SCLC-21H: 117.1;SK-MEL-30: 426.8;U-266/84: 341.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008406 Enhanced Approved Cytosol "Secreted to blood" NA NA 390000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 68: Epididymis - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 48: Smooth muscle cells - ECM organization" Cytosol "HPA008406: AB_1855981" "unprognostic (6.25e-3)" "unprognostic (6.69e-2)" "unprognostic (4.95e-2)" "unprognostic (1.44e-1)" "unprognostic (1.44e-2)" "unprognostic (9.32e-2)" "unprognostic (1.13e-3)" "unprognostic (9.73e-2)" "unprognostic (2.71e-3)" "unprognostic (7.86e-2)" "unprognostic (3.67e-2)" "unprognostic (1.17e-1)" "unprognostic (6.78e-2)" "unprognostic (7.76e-3)" "unprognostic (1.21e-1)" "unprognostic (9.48e-3)" "unprognostic (3.62e-3)" 5.6 170.3 8.4 14.2 7.5 47.3 15.8 5.1 11.5 21.2 4.2 25.3 5.6 9.8 104.0 3.4 2.2 10.8 5.1 8.9 27.4 6.1 2.6 5.6 8.1 9.7 11.6 1.0 13.7 14.8 27.0 9.2 14.7 7.2 10.2 11.9 25.5 6.7 4.1 36.3 4.5 8.3 7.8 13.9 7.6 2.0 20.3 5.1 3.8 2.8 12.5 15.2 4.6 6.7 1.0 40.7 0.1 0.0 6.0 13.3 0.1 6.6 86.5 6.4 10.1 2.9 7.1 0.2 3.0 32.6 72.9 0.1 2.7 0.6 10.3 0.6 76.0 18.7 0.3 7.7 0.6 3.0 0.1 8.5 0.0 47.3 0.2 0.4 26.2 0.0 0.0 0.0 0.2 4.5 0.0 1.7 0.6 0.3 0.0 0.0 0.0 0.8 42.6 10.9 117.1 0.2 6.4 1.4 426.8 8.0 0.7 2.9 19.4 0.0 0.2 0.1 0.6 15.3 341.7 0.3 25.8 0.3 0.0 9.8 344.8 3.2 0.4 38.7 1.0 2.6 0.6 0.5 124.7 1.2 0.5 0.3 1527.7 0.2 3.3 2.4 0.1 169.8 8.4 7.5 5.1 11.5 8.9 27.4 9.7 11.6 14.7 7.8 20.3 6.7 1.8 3.2 2.3 0.3 12.5 39.0 13.6 40.0 2.2 21.8 7.9 8.5 1.1 1.5 17.7 22.0 2.1 0.7 0.8 6.1 1.9 45.4 0.6 2.6 24.7 17.5 217.0 1.7 8.5 2.4 6.1 26.7 3.1 4.0 55.3 1.6 22.5 0.3 20.5 43.7 7.3 6.6 138.4 21.2 163.4 2.9 3.1 26.8 528.3 6.5 64.3 0.8 3.1 3.0 1.3 31.8 1.8 23.7 26.0 9.1 0.2 11.7 4.3 3.2 13.1 0.6 6.6 1.7 0.7 0.6 14.5 4.7 5.6 5.0 7.3 5.8 QTRT1 TGT ENSG00000213339 "Queuine tRNA-ribosyltransferase catalytic subunit 1" Q9BXR0 19 10701430-10713437 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "tRNA processing" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Intestinal goblet cells: 260.9;Paneth cells: 224.5;Proximal enterocytes: 261.8;Undifferentiated cells: 280.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042695, HPA048651, HPA049440" Approved Approved Mitochondria NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 29: Non-specific - Vesicular transport" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" Mitochondria "HPA042695: AB_2678119, HPA048651: AB_2680477, HPA049440: AB_2680767" "unprognostic (6.19e-2)" "prognostic favorable (7.63e-5)" "unprognostic (2.90e-2)" "unprognostic (3.05e-1)" "unprognostic (4.90e-2)" "prognostic favorable (4.90e-4)" "unprognostic (2.52e-1)" "unprognostic (8.76e-3)" "unprognostic (3.88e-1)" "unprognostic (4.81e-3)" "prognostic favorable (2.13e-4)" "unprognostic (1.14e-2)" "prognostic unfavorable (1.13e-6)" "unprognostic (2.04e-2)" "unprognostic (1.66e-1)" "unprognostic (3.13e-1)" "unprognostic (1.01e-3)" 17.2 27.1 11.2 11.8 11.4 13.4 18.1 10.0 15.9 18.4 9.4 20.0 10.3 22.7 2.7 20.5 20.9 7.3 21.4 11.8 11.3 18.3 30.2 12.5 12.2 10.8 10.6 24.4 51.9 9.6 17.6 7.7 11.1 16.9 5.0 6.1 22.3 9.2 20.5 18.3 15.2 6.1 10.8 14.8 20.7 6.4 11.3 7.0 20.7 10.2 5.1 17.6 16.4 11.6 41.5 32.3 14.6 44.1 15.3 18.2 19.7 20.8 18.3 23.8 22.9 25.6 15.0 47.1 50.1 11.5 14.4 26.6 13.8 24.9 7.7 28.1 20.8 30.4 13.3 55.7 26.6 46.4 25.7 27.8 20.3 15.3 22.1 10.5 24.2 25.5 35.0 50.2 11.8 64.2 39.7 56.5 40.3 25.3 53.5 41.2 19.9 72.2 18.8 26.1 48.4 21.6 33.0 33.4 27.8 6.2 21.5 19.0 19.5 35.0 20.3 58.2 49.7 56.7 48.3 23.3 19.3 55.0 44.4 1.9 16.6 0.4 29.6 31.4 37.4 42.0 31.7 26.4 34.0 40.8 33.3 27.5 1.3 43.9 16.6 39.8 37.9 21.3 11.2 11.4 10.0 15.9 11.8 11.3 10.8 10.6 11.1 10.8 11.3 11.6 23.2 0.0 4.5 47.3 36.6 63.7 63.5 59.0 65.4 36.7 42.6 48.6 7.3 30.0 24.5 57.0 50.1 47.8 27.3 157.0 64.6 25.8 1.6 19.8 28.8 24.7 192.5 30.3 32.8 27.6 39.7 33.5 23.9 18.8 16.5 43.7 18.2 33.9 28.8 90.9 31.4 260.9 42.7 15.8 30.9 2.6 50.7 12.8 49.8 8.4 10.5 22.0 7.2 21.6 30.0 13.9 224.5 37.6 53.2 43.6 261.8 80.3 22.6 57.9 19.7 40.7 31.1 12.9 24.6 36.9 41.9 28.0 27.0 67.4 280.7 37.2 QTRT2 "FLJ12960, QTRTD1" ENSG00000151576 "Queuine tRNA-ribosyltransferase accessory subunit 2" Q9H974 3 114005833-114088422 "Metabolic proteins, Predicted intracellular proteins" "tRNA processing" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 19.2;Alveolar cells type 2: 20.3;Endometrial stromal cells: 19.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036827, HPA036828" Uncertain Approved "Nucleoplasm,Intermediate filaments" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "Intermediate filaments" "HPA036827: AB_2675336, HPA036828: AB_10696788" "unprognostic (2.22e-1)" "unprognostic (1.11e-1)" "unprognostic (6.71e-3)" "unprognostic (1.01e-3)" "unprognostic (8.57e-2)" "unprognostic (4.41e-1)" "unprognostic (5.82e-3)" "unprognostic (3.58e-1)" "unprognostic (1.35e-1)" "unprognostic (6.94e-2)" "unprognostic (6.48e-3)" "prognostic unfavorable (6.95e-4)" "unprognostic (1.44e-1)" "unprognostic (8.74e-2)" "unprognostic (2.65e-2)" "unprognostic (1.98e-1)" "unprognostic (1.18e-3)" 6.9 6.5 3.6 9.4 3.9 11.2 10.1 3.2 4.0 7.4 9.0 8.4 7.7 8.4 6.4 7.0 7.5 5.3 3.4 4.3 3.6 7.5 7.2 8.6 12.0 3.8 3.6 8.1 6.7 7.3 4.4 8.5 3.8 6.9 8.9 11.3 5.9 5.9 3.8 8.2 7.6 7.4 3.4 11.8 6.9 7.1 3.7 7.7 8.9 3.9 11.6 9.6 5.2 4.4 26.8 27.1 22.2 24.6 9.6 11.7 20.9 13.7 8.6 22.9 20.9 26.0 18.8 49.4 19.5 12.7 27.3 25.9 43.5 20.6 29.9 9.4 19.6 22.2 15.9 18.6 13.7 40.8 20.0 9.3 18.2 20.8 29.4 9.3 24.0 22.5 23.7 17.1 13.1 21.4 34.3 15.9 42.6 37.6 29.3 30.6 15.6 26.6 18.0 18.2 30.1 14.2 19.9 19.4 25.1 18.4 21.6 20.4 15.9 19.9 21.6 7.9 26.9 12.0 18.7 68.1 17.4 29.6 40.9 0.6 15.3 3.8 6.4 15.8 6.0 16.8 5.4 6.3 19.4 11.0 7.4 6.0 6.5 8.6 11.4 8.1 7.6 6.5 3.6 3.9 3.2 4.0 4.3 3.6 3.8 3.6 3.8 3.4 3.7 4.4 14.0 19.2 20.3 0.0 8.4 0.0 0.0 0.0 0.0 0.0 13.8 12.4 0.0 0.0 10.5 3.7 0.0 10.9 10.0 0.0 1.9 15.7 0.0 16.3 19.7 9.9 0.0 0.0 0.0 12.4 10.9 6.2 0.0 15.1 15.2 15.7 0.0 0.0 11.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.2 0.0 0.0 8.3 0.0 0.0 0.0 0.0 16.7 0.0 0.0 3.3 0.0 0.0 8.9 4.4 0.0 0.0 0.0 5.2 0.0 0.0 0.0 0.0 4.9 4.3 17.4 0.0 0.0 RAD18 RNF73 ENSG00000070950 "RAD18 E3 ubiquitin protein ligase" Q9NS91 3 8775402-8963773 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "DNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006716, HPA006724, HPA008752" Supported Approved Enhanced "Nucleoplasm,Nuclear bodies" NA Yes "Cluster 2: Granulocytes - Unknown function" "Cluster 9: Intestine - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "Nucleoplasm, Nuclear bodies" "HPA006716: AB_2667650, HPA006724: AB_2667655, HPA008752: AB_2668129" "unprognostic (1.26e-1)" "unprognostic (1.07e-1)" "unprognostic (4.45e-2)" "unprognostic (1.25e-3)" "unprognostic (2.73e-2)" "unprognostic (6.15e-2)" "prognostic unfavorable (1.12e-4)" "unprognostic (2.01e-1)" "unprognostic (9.76e-2)" "unprognostic (1.17e-1)" "unprognostic (2.02e-2)" "prognostic unfavorable (3.73e-4)" "prognostic unfavorable (3.65e-5)" "unprognostic (1.97e-2)" "unprognostic (1.51e-1)" "unprognostic (7.92e-2)" "unprognostic (1.89e-2)" 2.7 2.3 1.2 3.3 1.5 5.2 5.3 1.3 1.7 3.2 0.5 3.8 10.1 2.8 1.9 3.4 2.3 3.1 1.8 1.5 0.9 1.6 2.7 2.7 4.6 1.6 1.0 2.8 1.7 2.0 1.3 3.0 1.5 3.2 4.9 2.6 3.2 1.6 1.3 4.5 6.5 2.8 1.2 3.5 2.2 2.9 1.1 5.8 3.7 1.0 4.4 2.5 2.9 2.3 16.2 15.2 12.3 7.4 3.0 6.4 14.9 25.0 8.5 23.5 16.1 13.7 10.1 19.8 4.7 14.2 13.8 5.6 13.1 13.0 23.8 12.2 17.2 16.9 16.1 8.2 1.9 22.7 13.9 2.4 4.6 23.3 15.7 6.3 7.7 17.1 18.2 19.0 20.9 18.6 22.9 15.9 17.2 12.7 28.5 18.0 13.6 15.6 6.9 12.2 5.1 11.5 11.2 10.5 8.2 9.7 11.0 9.8 6.4 19.4 10.5 16.8 21.7 9.6 16.1 43.7 14.3 24.5 14.6 6.4 1.6 5.1 1.5 1.7 2.8 1.9 2.1 2.7 2.0 1.9 2.2 1.6 0.7 2.8 1.1 3.6 3.0 0.8 1.2 1.5 1.3 1.7 1.5 0.9 1.6 1.0 1.5 1.2 1.1 2.3 5.7 16.0 9.8 6.2 7.7 11.1 7.5 6.4 5.7 4.6 7.3 11.7 2.2 4.3 7.5 3.7 2.1 9.0 8.6 5.2 1.9 9.6 4.2 4.0 5.8 4.6 1.8 7.2 20.9 8.2 12.4 6.8 3.6 4.9 13.9 14.8 6.1 3.1 7.1 3.3 15.7 6.5 2.0 5.2 5.6 3.0 4.1 4.6 3.6 14.0 7.1 3.2 8.2 16.1 14.3 10.2 4.3 2.6 8.7 6.4 4.0 3.1 4.1 2.3 6.6 4.3 6.9 26.2 14.0 6.0 11.8 6.7 7.5 9.3 6.3 3.6 RAF1 "c-Raf, CRAF, Raf-1" ENSG00000132155 "Raf-1 proto-oncogene, serine/threonine kinase" P04049 3 12583601-12664125 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Cardiomyopathy, Deafness, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 175.1" "Lineage enriched" "Detected in all" 5 "granulocytes: 175.1" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002639, HPA002640, CAB019291" Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 28: BEWO - Transcription regulation" "Cluster 40: Granulosa cells - Unknown function" "Plasma membrane, Cytosol" "CAB019291: , HPA002639: , HPA002640: AB_1856047" "unprognostic (6.33e-2)" "unprognostic (1.29e-1)" "unprognostic (5.92e-2)" "unprognostic (2.17e-3)" "unprognostic (6.51e-3)" "unprognostic (7.66e-3)" "unprognostic (2.66e-3)" "unprognostic (1.53e-2)" "unprognostic (2.72e-1)" "unprognostic (7.66e-2)" "unprognostic (2.92e-2)" "unprognostic (1.29e-2)" "unprognostic (2.79e-2)" "unprognostic (1.79e-1)" "unprognostic (1.27e-1)" "unprognostic (2.64e-2)" "unprognostic (2.36e-2)" 42.4 34.2 36.7 33.8 37.9 77.4 39.2 42.6 37.4 47.6 40.4 46.8 40.5 45.6 34.0 55.5 43.2 31.0 89.6 36.9 35.8 46.7 68.9 44.7 36.3 38.3 36.9 52.0 50.6 63.6 28.3 39.1 37.0 41.9 42.0 37.4 39.6 38.0 194.9 56.0 43.4 45.5 36.7 48.3 55.5 26.8 38.1 52.8 48.8 122.5 47.7 46.1 46.2 39.8 49.9 57.9 85.5 66.6 74.3 59.6 168.0 73.9 129.1 100.1 112.5 46.6 41.3 52.7 34.6 120.1 51.6 31.9 93.4 67.5 103.8 91.4 70.2 72.0 69.4 42.9 74.2 70.1 64.7 55.3 67.8 102.3 82.0 67.6 73.1 78.2 52.6 136.0 98.3 88.6 91.1 47.8 86.5 64.0 76.4 72.6 75.7 66.4 60.9 76.9 26.1 56.2 61.1 59.8 40.9 66.1 99.1 91.5 51.1 65.6 62.5 55.7 85.0 103.3 178.4 112.3 57.2 80.4 73.9 40.4 32.7 62.5 22.3 32.6 22.5 19.5 21.9 22.3 30.3 20.4 21.9 22.8 175.1 29.8 34.2 13.5 28.3 28.2 36.7 37.9 42.6 37.4 36.9 35.8 38.3 36.9 37.0 36.7 38.1 39.8 28.5 22.4 37.6 47.7 36.1 34.4 35.2 22.1 27.9 56.7 27.5 22.6 29.0 35.8 25.7 27.6 66.7 40.0 41.5 31.3 13.7 25.6 8.8 33.2 37.1 32.7 29.3 46.7 46.1 37.0 46.8 32.3 27.5 43.8 34.2 78.7 36.0 41.2 28.6 43.7 52.9 31.0 30.5 39.3 43.4 4.6 39.1 34.7 26.6 44.0 49.5 31.9 51.5 65.4 64.0 35.5 29.9 41.3 43.3 46.9 47.3 20.1 31.2 81.9 32.9 56.2 39.1 28.3 33.6 31.8 43.5 62.3 40.8 35.6 31.2 47.1 RAG1 "MGC43321, RNF74" ENSG00000166349 "Recombination activating 1" P15918 11 36510709-36593156 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "DNA recombination, Ubl conjugation pathway" "Chromatin regulator, DNA-binding, Endonuclease, Hydrolase, Multifunctional enzyme, Nuclease, Transferase" "Disease variant, SCID" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 92 "lymphoid tissue: 395.0" "Cell type enhanced" "Detected in some" "Distal tubular cells: 3.9;Hepatic stellate cells: 8.2" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "MOLT-4: 283.5;REH: 266.4" "Not detected" "Not detected" "Low region specificity" "Detected in some" HPA043939 Supported Nucleoplasm NA NA "Cluster 63: T-cells - Adaptive immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA043939: AB_2732512" "unprognostic (7.35e-2)" "unprognostic (1.57e-3)" "unprognostic (8.75e-2)" "unprognostic (3.44e-1)" "unprognostic (2.14e-1)" "unprognostic (1.46e-2)" "unprognostic (2.30e-1)" "unprognostic (1.70e-2)" "unprognostic (1.43e-1)" "unprognostic (1.54e-2)" "unprognostic (5.98e-3)" "unprognostic (1.28e-1)" "unprognostic (1.16e-9)" "unprognostic (2.16e-2)" "unprognostic (1.04e-1)" "unprognostic (2.53e-4)" "unprognostic (1.53e-1)" 0.4 0.5 0.1 0.2 0.1 4.3 0.2 0.1 0.2 0.4 0.2 0.4 0.8 0.2 0.8 0.1 0.3 0.4 0.3 0.1 0.1 1.3 0.8 0.6 0.1 0.1 0.1 0.3 0.3 0.6 0.1 0.6 0.1 0.3 0.3 0.6 0.4 0.3 0.1 0.1 1.0 0.1 0.1 2.6 0.5 0.3 0.1 395.0 2.4 0.3 0.6 0.3 0.1 0.1 0.4 0.0 0.5 0.1 0.2 0.6 0.0 0.3 0.3 0.1 0.5 0.0 0.4 0.5 0.0 0.0 0.1 0.2 0.0 0.4 0.4 0.1 0.0 0.2 0.0 0.0 0.1 0.0 0.1 0.3 0.4 0.0 0.3 0.2 0.5 54.0 0.2 0.0 0.5 0.0 283.5 0.0 2.2 0.2 0.0 266.4 0.0 1.3 0.9 0.0 0.1 0.3 0.1 0.7 0.1 1.2 1.0 0.1 1.0 0.2 0.2 0.2 0.1 2.3 1.9 0.0 0.0 0.2 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 1.5 0.0 0.0 0.0 0.1 0.1 1.4 0.7 0.0 1.0 1.0 0.8 0.9 0.0 0.4 1.8 0.0 0.2 0.5 1.3 3.9 0.8 2.3 0.3 0.3 1.6 0.0 0.4 1.8 0.5 0.1 0.7 0.0 0.4 0.0 0.3 8.2 2.1 0.4 0.0 1.7 0.8 0.0 0.6 0.7 1.7 0.0 0.1 0.0 1.0 1.1 0.5 2.1 1.0 1.3 1.1 0.4 0.0 0.0 0.5 3.0 2.9 0.4 0.9 0.0 0.2 0.7 1.0 1.0 0.2 0.4 0.4 0.4 0.5 0.6 0.6 RBBP6 "P2P-R, PACT, SNAMA" ENSG00000122257 "RB binding protein 6, ubiquitin ligase" Q7Z6E9 16 24537693-24572863 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA replication, Host-virus interaction, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 143.6" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032866, HPA041725, HPA043544" Approved Enhanced "Nuclear speckles" NA NA "Cluster 11: Basophils - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" "Nuclear speckles" "CAB032866: AB_2177791, HPA041725: AB_2677639, HPA043544: AB_2678543" "unprognostic (1.04e-1)" "unprognostic (5.08e-2)" "unprognostic (3.35e-1)" "unprognostic (3.85e-2)" "unprognostic (1.97e-2)" "unprognostic (2.15e-2)" "unprognostic (1.08e-2)" "unprognostic (6.60e-2)" "unprognostic (2.70e-3)" "unprognostic (1.29e-2)" "unprognostic (1.77e-1)" "unprognostic (2.01e-2)" "unprognostic (1.21e-2)" "unprognostic (1.44e-1)" "unprognostic (1.01e-1)" "unprognostic (1.22e-1)" "unprognostic (2.83e-2)" 27.1 25.0 22.9 21.1 23.8 143.6 25.9 33.1 29.9 27.8 21.7 31.5 15.0 33.6 26.3 23.2 32.4 25.5 23.9 22.8 23.5 24.3 26.8 27.9 29.7 24.2 22.8 38.8 22.2 21.8 28.1 31.7 24.4 26.0 20.4 51.1 21.4 19.9 29.7 34.6 26.0 24.1 23.9 29.4 25.6 45.5 24.4 26.6 27.2 25.7 23.5 25.3 24.7 27.7 35.4 18.4 42.5 44.4 31.9 32.9 45.9 28.1 26.1 25.1 27.3 20.5 28.3 49.6 20.3 24.4 28.7 33.3 46.2 24.8 41.9 26.9 35.7 41.9 57.1 58.6 24.7 57.5 23.7 28.8 33.7 33.2 38.9 28.6 36.9 42.2 54.5 43.8 29.7 36.5 45.5 51.2 48.7 24.0 17.3 62.8 42.5 43.3 24.7 31.7 33.4 28.5 39.7 35.1 52.3 47.0 27.4 49.7 32.3 31.0 22.8 27.0 30.8 37.7 40.9 60.9 25.1 36.5 26.1 7.1 1.2 2.0 2.0 2.0 2.2 2.0 2.1 1.5 0.9 1.7 1.8 2.0 2.5 3.5 1.1 3.7 1.7 0.6 22.9 23.8 33.1 29.9 22.8 23.5 24.2 22.8 24.4 23.9 24.4 27.7 139.1 86.6 115.3 47.3 125.7 100.7 103.5 40.8 223.1 67.1 145.6 160.8 147.0 44.3 56.5 27.6 100.1 46.3 88.9 71.5 25.4 48.8 307.5 109.8 123.7 93.7 82.0 83.1 52.5 47.6 57.6 127.1 121.8 203.1 51.3 127.8 64.2 59.5 38.4 62.2 53.4 76.0 28.5 53.5 70.2 41.9 72.4 101.5 62.2 54.4 54.0 53.1 52.5 61.3 58.7 56.4 32.8 58.6 173.7 99.9 54.5 23.9 52.0 61.4 52.6 247.0 112.9 100.3 45.8 161.0 101.7 101.5 110.2 105.3 69.3 111.9 RCHY1 "ARNIP, CHIMP, DKFZp586C1620, PIRH2, PRO1996, RNF199, ZCHY, ZNF363" ENSG00000163743 "Ring finger and CHY zinc finger domain containing 1" Q96PM5 4 75479037-75514764 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030338, HPA030339" Approved Supported Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Cytosol "Nucleoplasm, Vesicles" "HPA030338: , HPA030339: AB_10603232" "unprognostic (1.53e-1)" "unprognostic (1.57e-1)" "prognostic favorable (9.09e-4)" "unprognostic (1.90e-1)" "unprognostic (3.45e-3)" "unprognostic (1.19e-2)" "unprognostic (7.87e-3)" "unprognostic (5.82e-2)" "unprognostic (1.96e-1)" "unprognostic (1.98e-1)" "unprognostic (7.45e-3)" "unprognostic (4.60e-2)" "prognostic favorable (3.62e-5)" "unprognostic (1.69e-1)" "unprognostic (2.07e-1)" "unprognostic (1.83e-1)" "prognostic favorable (7.89e-5)" 8.6 7.0 9.5 7.9 10.2 17.0 16.8 12.6 13.0 9.0 7.7 12.1 8.7 9.6 6.9 7.2 11.9 6.8 16.8 9.4 10.6 16.2 12.3 10.0 9.5 8.9 10.4 14.5 8.3 12.6 5.8 10.0 9.9 10.9 13.2 14.8 12.9 10.1 16.5 5.6 8.6 11.6 9.9 11.5 8.9 13.6 10.7 12.7 18.9 23.6 12.6 7.6 4.7 10.7 9.8 5.0 14.6 13.8 15.1 13.1 8.4 6.5 15.1 13.2 15.4 13.8 11.9 16.2 12.0 9.4 13.1 5.8 37.6 11.5 19.9 13.4 12.3 21.2 9.2 17.9 13.0 28.9 11.2 12.2 14.1 15.2 14.2 15.9 27.0 20.8 19.9 16.2 30.9 15.8 26.7 11.5 24.5 26.9 8.7 14.2 34.4 13.9 20.4 16.7 22.6 12.4 10.7 24.8 28.2 15.9 14.0 12.9 10.8 8.6 8.5 7.8 11.1 17.0 13.0 22.8 10.5 20.2 14.0 27.5 9.2 9.7 4.3 5.7 7.6 4.6 5.4 5.2 8.0 2.1 3.9 5.5 4.0 5.5 5.6 4.1 5.7 4.7 9.5 10.2 12.6 13.0 9.4 10.6 8.9 10.4 9.9 9.9 10.7 10.7 22.2 19.2 10.3 28.4 25.4 40.7 32.3 47.1 39.3 35.0 38.5 25.9 56.8 24.3 23.5 23.9 20.9 31.6 31.2 21.9 68.4 30.3 37.3 11.9 17.1 22.3 13.8 21.8 31.2 22.5 23.2 24.6 21.9 17.3 5.1 23.8 25.4 23.0 19.0 23.5 32.3 23.4 38.7 37.5 26.8 59.8 22.4 27.4 28.4 22.5 23.9 32.0 24.7 31.7 41.0 26.5 22.6 25.2 19.7 36.6 24.6 69.4 13.5 21.7 32.9 20.9 27.3 72.8 41.7 28.1 31.0 33.8 32.9 35.2 27.6 26.3 RCL1 "RNAC, RPCL1" ENSG00000120158 "RNA terminal phosphate cyclase like 1" Q9Y2P8 9 4792944-4885917 "Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ribosome biogenesis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 245.8" "Cell type enhanced" "Detected in many" "Early spermatids: 74.1;Hepatocytes: 183.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Group enriched" "Detected in all" 4 "HDLM-2: 145.5;HEL: 375.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA071308 Approved Nucleoplasm NA NA "Cluster 44: Non-specific - Transcription" "Cluster 85: Liver - Metabolism" "Cluster 36: HEL - Hemostasis" "Cluster 2: Hepatocytes - Metabolism" Nucleoplasm "HPA071308: AB_2686384" "prognostic favorable (5.48e-4)" "unprognostic (7.60e-3)" "unprognostic (7.55e-2)" "unprognostic (4.19e-2)" "unprognostic (1.07e-2)" "unprognostic (3.29e-1)" "prognostic favorable (8.02e-4)" "unprognostic (3.55e-1)" "unprognostic (1.47e-1)" "unprognostic (2.81e-2)" "unprognostic (1.19e-1)" "unprognostic (2.59e-2)" "prognostic favorable (2.40e-7)" "unprognostic (1.01e-1)" "unprognostic (1.06e-1)" "unprognostic (2.27e-1)" "unprognostic (3.66e-2)" 37.2 13.4 5.8 9.0 7.8 44.3 21.7 6.5 7.3 9.4 8.2 7.5 4.1 8.3 9.9 10.4 10.6 6.3 6.6 5.9 8.0 12.3 245.8 13.1 15.0 8.4 7.9 17.6 64.6 8.7 7.0 13.8 8.8 7.0 7.5 3.8 6.8 7.1 14.4 21.1 8.0 7.7 8.3 9.2 10.4 13.8 8.1 9.7 8.2 8.6 12.5 12.5 10.6 10.2 23.3 27.6 10.3 16.5 15.0 10.1 27.3 10.8 12.0 19.9 16.8 13.9 13.4 45.2 7.4 9.7 22.1 14.4 48.0 32.5 22.8 145.5 24.2 375.0 33.5 28.1 21.5 34.1 28.9 22.4 18.2 19.0 28.7 11.2 19.7 32.4 38.9 28.0 12.0 30.4 27.8 57.8 35.7 27.7 11.0 34.2 13.8 24.2 24.3 25.9 29.6 24.3 13.6 20.0 15.8 20.4 18.9 39.8 13.9 11.6 13.3 16.6 34.0 11.5 35.3 48.1 21.3 20.8 8.1 16.2 1.6 4.3 5.7 2.5 7.0 8.7 6.5 7.7 4.3 11.5 8.7 9.0 0.6 12.1 1.3 7.4 5.9 3.7 5.8 7.8 6.5 7.3 5.9 8.0 8.4 7.9 8.8 8.3 8.1 10.2 10.9 6.4 6.8 18.9 14.7 25.5 21.8 11.9 25.0 5.4 9.3 8.0 10.6 11.5 7.8 3.7 0.0 39.8 8.5 3.0 25.4 12.4 74.1 8.3 8.8 12.1 3.0 68.4 14.1 11.5 16.6 11.9 8.6 5.7 14.5 16.7 16.1 183.4 17.7 5.0 15.9 6.4 6.1 11.3 6.2 39.7 23.0 7.6 3.6 36.5 9.7 9.2 5.2 18.1 34.3 10.6 3.7 37.6 14.3 18.1 3.2 13.7 14.0 7.0 13.1 19.1 10.2 18.2 18.4 18.6 21.2 35.4 8.9 12.1 8.9 16.6 RFWD3 "FANCW, FLJ10520, RNF201" ENSG00000168411 "Ring finger and WD repeat domain 3" Q6PCD5 16 74621399-74666877 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Disease variant, Fanconi anemia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 47.7" "Cell type enhanced" "Detected in many" "Spermatocytes: 48.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA048258, HPA075649" Approved Enhanced Nucleoplasm,Cytosol No No "Cluster 42: Non-specific - Transcription" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm Cytosol "HPA048258: AB_2680332, HPA075649: AB_2686761" "unprognostic (4.79e-2)" "unprognostic (6.45e-3)" "unprognostic (6.35e-2)" "unprognostic (6.61e-2)" "unprognostic (2.73e-1)" "unprognostic (1.97e-1)" "unprognostic (1.11e-3)" "unprognostic (5.04e-2)" "unprognostic (3.64e-2)" "unprognostic (1.01e-1)" "unprognostic (4.03e-3)" "unprognostic (2.53e-3)" "unprognostic (1.73e-3)" "unprognostic (2.84e-1)" "unprognostic (4.31e-1)" "unprognostic (5.74e-2)" "unprognostic (3.29e-1)" 5.2 3.9 2.5 9.9 3.5 47.7 7.6 4.0 3.2 6.4 4.4 8.0 6.5 6.2 5.3 9.4 6.8 6.5 2.9 2.3 2.9 6.7 5.8 6.1 15.4 3.3 3.1 7.0 10.2 6.8 3.8 8.0 3.2 4.9 9.3 6.2 5.8 5.1 3.3 12.6 6.1 6.1 2.8 8.1 6.2 25.2 3.4 27.1 6.6 2.7 16.7 7.2 6.8 4.7 46.1 57.5 42.6 31.2 8.8 11.9 47.8 40.5 30.9 63.0 54.5 75.4 46.8 63.6 32.1 31.8 31.6 53.9 70.3 42.1 76.9 20.0 42.1 56.3 46.0 43.0 7.6 57.3 56.3 8.6 13.2 79.6 48.7 16.3 27.3 53.2 86.7 27.7 48.1 72.8 84.0 52.2 84.0 26.8 27.7 128.7 28.8 55.9 22.7 47.8 31.5 33.6 65.2 22.8 28.8 38.2 41.7 48.4 26.7 46.0 43.9 26.2 51.4 37.4 75.1 188.3 32.8 43.5 57.0 12.1 4.4 6.5 5.5 4.1 6.1 4.9 4.5 5.1 4.6 5.4 6.7 4.8 4.9 6.2 7.7 3.5 7.2 4.4 2.5 3.5 4.0 3.2 2.3 2.9 3.3 3.1 3.2 2.8 3.4 4.7 6.0 0.0 5.9 4.2 13.2 10.8 6.8 4.0 10.2 6.6 8.4 8.3 3.9 2.8 5.4 1.8 10.4 12.1 15.3 7.6 11.7 6.2 5.4 6.9 5.7 7.2 9.5 22.5 8.9 7.6 8.3 5.9 5.1 6.6 4.5 13.5 11.7 7.4 8.9 3.3 7.1 9.7 2.0 12.2 6.0 6.3 3.7 7.8 16.0 15.0 7.6 3.0 10.3 6.6 15.2 10.0 2.7 4.1 11.6 12.7 4.3 4.6 5.9 6.7 6.6 6.4 5.6 48.5 31.7 9.5 9.2 7.5 10.6 3.6 9.5 11.4 RING1 RNF1 ENSG00000204227 "Ring finger protein 1" Q06587 6 33208500-33212722 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "Chromatin regulator, Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008701 Supported Approved Nucleoplasm,Cytosol NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 35: Non-specific - Unknown function" "Cluster 44: HDLM-2 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" Nucleoplasm Cytosol "HPA008701: AB_1079814" "unprognostic (2.12e-3)" "unprognostic (7.98e-2)" "unprognostic (3.77e-2)" "unprognostic (1.37e-1)" "unprognostic (3.91e-2)" "unprognostic (3.21e-1)" "unprognostic (1.53e-1)" "unprognostic (4.75e-2)" "unprognostic (7.76e-2)" "unprognostic (1.26e-2)" "unprognostic (3.70e-2)" "unprognostic (1.62e-2)" "unprognostic (2.22e-1)" "unprognostic (1.04e-1)" "unprognostic (1.55e-1)" "unprognostic (2.13e-1)" "unprognostic (9.88e-2)" 38.6 42.4 39.2 21.6 42.7 18.1 36.8 39.7 45.6 60.2 42.2 45.4 21.3 51.5 20.8 37.4 51.8 19.3 37.0 38.7 41.4 50.7 51.2 39.3 20.9 39.4 42.7 59.4 44.7 34.2 80.8 19.4 40.6 55.8 7.2 15.7 37.0 23.2 37.3 34.7 37.0 29.6 39.9 41.2 37.5 46.9 43.4 34.4 67.1 25.4 17.3 41.3 42.2 47.5 38.8 24.9 38.2 33.3 35.0 13.2 15.5 36.5 55.1 32.7 40.5 35.2 22.9 30.1 19.0 41.2 45.8 21.0 31.6 29.7 24.5 69.5 16.5 60.2 50.4 40.2 75.9 37.7 57.0 0.0 26.7 34.4 53.6 38.1 16.5 30.4 49.2 37.2 37.2 0.0 6.3 22.1 13.6 24.5 17.0 18.1 27.1 59.6 42.9 41.5 43.6 32.4 26.3 34.8 62.9 11.6 40.2 56.7 26.1 37.6 29.7 5.6 43.8 56.4 37.1 32.6 25.5 36.0 28.7 0.0 0.4 1.6 0.0 0.2 0.6 0.8 0.5 0.6 0.4 0.2 0.6 1.3 0.6 0.5 0.5 1.1 0.8 0.4 39.2 42.7 39.7 45.6 38.7 41.4 39.4 42.7 40.6 39.9 43.4 47.5 27.5 0.0 20.2 22.5 23.6 27.5 40.6 28.6 51.2 32.1 26.8 25.3 23.9 21.5 22.1 22.0 16.7 41.9 30.8 23.7 15.6 32.8 34.7 28.4 29.0 26.8 30.6 16.8 23.2 34.7 35.2 32.2 31.6 29.5 19.7 19.7 35.0 36.9 29.1 25.2 23.0 24.1 8.2 26.5 23.5 21.5 40.0 22.3 17.8 12.2 21.0 44.8 21.6 12.5 20.3 31.2 25.1 29.7 32.2 29.4 36.6 34.8 25.9 21.6 26.3 38.3 30.9 33.4 18.9 32.7 30.5 63.1 27.6 32.6 21.8 30.2 RIOK1 "AD034, bA288G3.1, FLJ30006, RRP10" ENSG00000124784 "RIO kinase 1" Q9BRS2 6 7389793-7418037 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ribosome biogenesis" "Hydrolase, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017866, HPA051446" Enhanced Supported Cytosol NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" Cytosol "HPA017866: AB_2669670, HPA051446: AB_2681488" "unprognostic (2.33e-2)" "unprognostic (1.24e-1)" "unprognostic (2.38e-1)" "unprognostic (1.03e-2)" "unprognostic (1.16e-1)" "unprognostic (1.51e-1)" "prognostic unfavorable (3.41e-5)" "unprognostic (2.23e-1)" "prognostic unfavorable (4.43e-4)" "unprognostic (3.45e-2)" "unprognostic (1.47e-1)" "unprognostic (1.87e-1)" "prognostic unfavorable (5.85e-5)" "unprognostic (2.33e-1)" "unprognostic (2.09e-1)" "unprognostic (6.12e-3)" "unprognostic (2.59e-2)" 12.1 9.3 4.1 10.8 4.1 20.6 11.0 5.0 5.3 10.0 3.7 7.9 6.5 10.5 5.2 11.4 8.2 7.5 8.0 4.2 5.1 6.4 7.9 7.1 14.0 4.7 5.1 10.9 10.2 7.3 4.7 11.4 4.6 8.0 8.6 7.3 7.0 8.1 11.5 9.1 6.3 10.8 4.2 9.4 7.0 19.9 4.5 15.7 7.3 10.3 15.9 14.9 7.6 4.7 20.4 11.7 18.3 45.8 27.0 22.6 28.7 25.6 16.6 22.1 18.5 33.1 10.0 51.8 43.3 19.7 19.4 20.3 45.7 19.5 29.0 35.8 49.6 28.3 18.3 39.4 23.0 81.5 37.5 17.2 27.2 24.1 50.4 11.5 20.1 38.6 72.1 12.3 21.0 26.7 56.8 50.2 39.6 36.3 26.1 42.9 23.3 56.6 13.8 19.9 60.8 30.4 20.8 13.3 41.6 48.4 18.9 28.4 19.9 24.4 18.9 17.5 38.3 17.1 33.0 75.7 7.7 44.0 38.7 12.0 11.5 9.0 14.9 15.6 18.0 21.5 15.4 15.9 20.5 23.0 17.8 19.2 2.3 26.7 14.0 17.3 16.2 11.3 4.1 4.1 5.0 5.3 4.2 5.1 4.7 5.1 4.6 4.2 4.5 4.7 22.2 6.4 26.4 5.5 27.5 52.8 32.3 29.5 38.1 10.0 18.9 22.0 22.8 4.3 35.2 7.3 10.4 34.1 25.3 9.9 3.9 15.9 74.8 14.9 28.4 24.8 7.2 17.9 10.2 11.7 34.7 29.8 16.8 19.1 33.6 13.4 19.2 10.2 22.6 5.0 12.0 17.4 20.3 11.2 25.1 12.5 19.9 19.7 17.8 11.2 15.1 8.9 6.2 13.0 8.4 12.2 8.2 19.9 27.0 33.7 7.1 9.3 20.9 13.7 19.7 33.8 23.9 58.9 75.4 33.7 64.8 27.9 29.0 23.9 16.9 23.8 RIOK2 FLJ11159 ENSG00000058729 "RIO kinase 2" Q9BVS4 5 97160867-97183247 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Ribosome biogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005681 Uncertain Approved "Plasma membrane,Cytosol" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 54: Non-specific - Microtubule organization" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 7: Non-specific - Mitochondria" Cytosol "Plasma membrane" "HPA005681: AB_1856286" "unprognostic (6.36e-2)" "unprognostic (1.21e-1)" "unprognostic (1.13e-2)" "unprognostic (8.04e-2)" "unprognostic (1.38e-1)" "unprognostic (4.51e-2)" "unprognostic (2.71e-3)" "unprognostic (3.08e-1)" "unprognostic (3.90e-2)" "unprognostic (1.11e-1)" "unprognostic (8.76e-2)" "unprognostic (6.63e-2)" "unprognostic (1.26e-3)" "unprognostic (3.60e-1)" "unprognostic (9.98e-2)" "unprognostic (1.43e-2)" "unprognostic (1.39e-2)" 15.0 14.6 12.5 13.5 13.7 21.5 14.7 16.6 21.3 12.9 14.1 13.3 13.0 11.6 12.2 13.5 12.3 7.8 16.3 12.5 14.7 14.2 18.1 10.3 14.3 13.5 13.5 14.8 16.7 11.3 15.1 12.1 13.5 12.0 12.7 19.4 11.8 9.3 21.4 11.3 11.2 9.3 13.9 14.6 13.3 12.6 13.7 13.7 11.9 14.2 13.6 13.2 12.1 15.9 19.0 22.0 20.3 38.5 25.9 28.6 32.1 48.1 29.0 33.0 43.2 30.4 32.5 41.7 53.1 21.3 51.6 21.7 34.2 27.4 44.9 29.3 18.5 20.3 44.0 42.9 23.6 38.5 27.2 18.5 20.8 40.1 39.8 25.0 27.0 30.8 31.7 25.4 38.0 31.9 46.4 47.8 22.5 10.6 23.9 51.9 38.3 61.9 25.7 16.9 23.7 17.9 27.5 28.3 35.6 29.6 29.6 36.4 28.5 41.2 28.9 33.0 51.8 25.3 36.4 95.2 24.0 39.7 38.4 17.9 26.2 15.8 24.6 30.7 34.4 24.0 31.5 27.8 29.4 18.6 33.9 36.5 5.0 30.7 23.8 29.2 31.7 22.7 12.5 13.7 16.6 21.3 12.5 14.7 13.5 13.5 13.5 13.9 13.7 15.9 14.9 9.6 12.8 7.8 16.9 26.4 17.9 25.2 12.5 16.2 11.1 11.4 20.5 10.0 17.4 7.3 12.5 19.6 26.9 6.4 17.6 17.3 1.3 10.7 18.0 14.0 9.6 8.4 10.9 14.9 24.8 21.1 14.8 10.5 27.9 12.7 8.2 8.1 18.3 13.5 11.0 12.7 18.3 9.4 9.2 3.0 13.4 11.0 5.4 3.7 16.5 13.4 14.4 9.0 15.0 11.4 10.1 16.1 19.1 10.4 11.8 17.3 13.3 17.7 6.6 17.4 22.9 23.5 20.7 10.1 18.9 17.4 19.6 19.4 12.6 12.0 RIOK3 SUDD ENSG00000101782 "RIO kinase 3" O14730 18 23453287-23486603 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Antiviral defense, Immunity, Innate immunity, Ribosome biogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 174.3" "Cell type enhanced" "Detected in all" "Distal enterocytes: 338.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001620, HPA024184" Approved Approved "Golgi apparatus,Plasma membrane,Centriolar satellite,Cytosol" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 30: Epithelial cell lines - Translation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane, Cytosol" "Golgi apparatus, Centriolar satellite" "HPA001620: AB_1079815, HPA024184: AB_1856289" "unprognostic (7.99e-2)" "unprognostic (1.71e-2)" "unprognostic (2.39e-1)" "unprognostic (3.03e-2)" "unprognostic (1.05e-1)" "unprognostic (7.48e-2)" "unprognostic (8.98e-3)" "unprognostic (1.01e-1)" "unprognostic (5.10e-2)" "unprognostic (4.20e-1)" "prognostic unfavorable (4.10e-4)" "prognostic unfavorable (5.80e-4)" "unprognostic (3.90e-2)" "unprognostic (1.46e-1)" "unprognostic (5.44e-2)" "unprognostic (1.39e-1)" "unprognostic (2.71e-2)" 23.1 18.5 5.5 20.4 7.1 174.3 19.2 7.9 10.2 17.4 8.3 47.5 51.6 16.7 12.4 65.5 14.8 24.3 32.7 5.9 6.7 29.6 55.6 22.7 22.8 9.3 7.3 15.7 27.6 22.8 5.4 34.9 8.9 20.1 43.5 19.6 23.2 14.5 52.9 33.3 62.5 19.7 7.5 21.5 38.5 36.6 6.9 21.5 22.2 48.8 30.2 25.8 27.0 10.6 41.9 15.7 17.8 25.0 31.8 37.7 28.5 38.9 29.8 27.6 28.4 17.3 47.5 27.6 52.3 43.7 26.9 57.6 25.9 45.4 38.9 29.5 12.0 25.9 26.9 22.2 71.7 74.7 25.8 39.0 91.2 44.1 66.7 36.7 38.4 19.2 39.8 34.7 45.0 19.4 25.8 15.6 17.6 59.0 31.3 31.3 33.2 41.2 39.3 50.0 39.5 28.9 50.1 28.4 37.4 41.0 21.9 45.0 63.7 48.4 10.9 21.2 28.9 66.1 56.0 38.2 31.0 36.7 38.2 50.1 24.5 14.8 15.0 34.6 10.8 14.0 12.3 12.6 19.1 18.5 9.8 11.2 17.2 15.0 39.0 8.6 19.4 20.7 5.5 7.1 7.9 10.2 5.9 6.7 9.3 7.3 8.9 7.5 6.9 10.6 49.7 80.1 57.7 23.2 46.4 120.4 92.4 78.6 113.8 44.1 49.3 35.6 69.1 51.5 81.5 25.8 56.3 43.0 74.6 338.1 25.4 51.0 271.5 130.1 85.5 44.1 62.8 259.8 35.5 52.7 64.6 48.8 93.8 267.2 63.3 40.0 29.6 88.5 41.1 28.6 34.2 119.9 50.8 59.9 51.2 305.8 22.4 85.7 42.7 15.9 80.6 18.3 53.5 34.2 49.5 148.4 210.7 30.1 63.4 118.5 199.5 52.5 72.3 46.4 6.6 43.9 51.6 28.4 10.1 164.2 143.6 88.4 57.3 71.1 77.2 244.4 RIPK1 RIP ENSG00000137275 "Receptor interacting serine/threonine kinase 1" Q13546 6 3063824-3115187 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Inflammatory response, Necrosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010302, HPA015257" Supported Approved "Plasma membrane,Cytosol" NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 18: Non-specific - Mitochondria" "Cluster 44: HDLM-2 - Immune response" "Cluster 7: Non-specific - Mitochondria" "Plasma membrane, Cytosol" "CAB010302: AB_2178118, HPA015257: AB_1856294" "unprognostic (1.24e-1)" "unprognostic (6.83e-2)" "unprognostic (1.87e-1)" "unprognostic (7.75e-2)" "unprognostic (6.08e-2)" "unprognostic (1.01e-2)" "unprognostic (1.26e-2)" "unprognostic (1.96e-1)" "unprognostic (9.46e-2)" "unprognostic (1.46e-1)" "unprognostic (5.00e-2)" "unprognostic (3.29e-1)" "unprognostic (9.65e-3)" "unprognostic (3.44e-1)" "unprognostic (9.01e-2)" "unprognostic (1.38e-2)" "prognostic favorable (6.71e-4)" 18.5 12.0 1.9 9.3 1.9 0.5 16.2 1.8 3.8 12.8 2.4 17.5 12.3 14.5 5.3 17.6 12.8 10.6 11.8 1.8 1.9 13.7 23.6 13.5 10.1 2.2 1.9 8.5 17.4 12.2 12.3 10.9 2.0 13.7 13.0 2.4 16.4 8.9 11.7 20.7 19.9 11.9 2.0 19.4 16.5 5.3 2.0 11.9 14.4 5.0 13.0 15.5 13.7 1.9 14.4 9.8 12.9 12.4 27.6 19.2 5.5 21.4 30.8 22.8 26.7 12.4 8.0 13.8 20.9 30.1 23.2 14.3 17.9 17.2 24.3 27.8 9.4 16.7 4.5 6.9 17.2 15.6 20.1 24.8 15.1 20.4 15.3 17.6 20.6 6.2 19.4 4.6 22.0 17.8 10.7 7.7 8.8 17.4 12.7 11.8 10.9 14.5 17.3 27.2 11.3 12.2 14.7 7.8 22.4 26.0 15.2 8.7 25.1 20.6 12.1 8.2 16.4 9.8 15.3 13.5 8.9 7.0 27.7 0.1 0.4 0.9 0.6 0.9 1.0 0.3 0.9 1.7 1.0 1.2 0.7 0.7 0.0 1.5 0.5 0.5 1.7 0.8 1.9 1.9 1.8 3.8 1.8 1.9 2.2 1.9 2.0 2.0 2.0 1.9 28.6 6.4 12.0 17.3 14.7 11.0 10.3 6.6 16.5 4.4 14.7 17.8 8.6 17.2 16.7 9.2 12.5 8.9 21.9 27.1 5.9 9.4 2.0 10.5 14.0 16.7 6.6 7.2 23.1 12.9 7.7 18.3 27.0 13.4 10.8 8.7 10.0 14.6 11.6 5.0 26.7 17.7 4.1 6.7 11.1 0.8 6.8 15.3 3.6 11.2 13.8 6.6 12.3 14.6 16.2 13.8 11.7 6.0 22.3 11.3 12.7 8.7 17.4 21.4 19.7 32.5 17.9 1.2 2.8 20.5 9.9 11.9 20.8 10.6 11.3 14.5 RIPK2 "CARD3, CARDIAK, RICK, RIP2" ENSG00000104312 "Receptor interacting serine/threonine kinase 2" O43353 8 89757806-89791064 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Adaptive immunity, Apoptosis, Immunity, Innate immunity" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Glandular and luminal cells: 156.1;Langerhans cells: 121.3;Macrophages: 105.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "hTERT-HME1: 49.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015273, HPA016499" Approved Enhanced Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 30: Epithelial cell lines - Translation" "Cluster 41: Macrophages - Immune response" Cytosol "HPA015273: AB_1856299, HPA016499: AB_1856300" "unprognostic (1.20e-1)" "unprognostic (1.02e-2)" "unprognostic (2.35e-1)" "unprognostic (3.82e-2)" "unprognostic (1.67e-1)" "unprognostic (6.20e-2)" "unprognostic (1.43e-3)" "prognostic unfavorable (6.33e-5)" "unprognostic (2.06e-1)" "unprognostic (7.80e-2)" "prognostic unfavorable (5.00e-6)" "unprognostic (6.39e-2)" "prognostic unfavorable (0.00e+0)" "unprognostic (1.84e-2)" "unprognostic (5.08e-2)" "unprognostic (1.05e-2)" "prognostic favorable (8.05e-4)" 4.1 1.6 4.0 5.6 4.0 8.9 5.1 4.0 5.5 4.7 3.3 2.9 1.7 5.5 2.4 3.0 2.7 9.4 4.4 4.1 5.5 3.7 5.6 6.0 6.5 4.6 4.0 2.5 4.4 4.2 1.9 4.7 5.1 5.3 2.9 1.5 5.0 2.7 0.6 4.2 2.4 5.7 5.3 4.8 2.9 2.9 3.7 2.8 4.2 1.3 6.7 9.4 2.6 6.0 17.8 6.0 3.2 4.9 7.9 10.8 5.5 19.2 36.1 10.7 13.6 4.6 9.7 14.4 28.0 11.7 7.6 4.2 8.9 6.9 20.2 8.7 8.0 11.9 2.8 5.5 22.2 4.5 5.8 8.8 5.6 15.6 49.8 11.4 11.4 0.0 5.4 4.7 10.2 3.4 0.0 9.6 1.5 8.4 14.4 3.2 4.1 7.5 26.1 8.4 0.4 3.1 4.7 12.6 10.0 4.0 12.0 5.6 10.1 6.5 6.0 11.2 9.1 8.9 4.2 8.8 16.2 0.4 4.3 13.7 6.6 23.2 3.5 12.5 4.1 7.6 5.4 4.6 8.1 4.8 4.9 5.4 5.1 4.4 14.9 2.6 1.3 4.6 4.0 4.0 4.0 5.5 4.1 5.5 4.6 4.0 5.1 5.3 3.7 6.0 19.3 35.3 18.1 25.5 29.8 57.6 33.7 13.3 16.5 2.1 17.2 8.9 5.2 4.3 22.9 3.7 0.0 13.3 32.8 2.8 5.9 80.1 6.6 82.3 23.7 15.0 0.0 9.9 12.9 60.8 45.7 27.3 9.7 156.1 43.1 7.1 6.1 3.2 41.7 3.3 9.1 5.4 24.4 32.4 121.3 2.5 7.8 105.1 19.6 15.0 42.1 12.1 8.2 15.6 12.8 50.0 2.7 6.0 22.0 59.2 2.2 10.4 11.6 0.3 13.1 19.2 19.6 7.9 12.8 14.7 48.3 83.7 30.4 7.5 8.1 49.5 RIPK3 RIP3 ENSG00000129465 "Receptor interacting serine/threonine kinase 3" Q9Y572 14 24336025-24340022 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Necrosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 38.5;Exocrine glandular cells: 35.2;Gastric mucus-secreting cells: 22.4;Paneth cells: 21.4;Proximal enterocytes: 22.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "CAPAN-2: 7.0;HDLM-2: 4.1;OE19: 10.1;SK-BR-3: 11.1" "Not detected" "Not detected" "Low region specificity" "Detected in many" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 64: Macrophages - Immune response" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "unprognostic (1.85e-2)" "unprognostic (1.66e-1)" "unprognostic (5.16e-3)" "unprognostic (1.12e-2)" "unprognostic (1.95e-1)" "unprognostic (1.29e-1)" "unprognostic (1.19e-1)" "unprognostic (2.32e-1)" "unprognostic (3.25e-1)" "unprognostic (2.02e-1)" "unprognostic (3.31e-2)" "unprognostic (1.11e-1)" "unprognostic (5.26e-3)" "unprognostic (9.58e-2)" "unprognostic (5.58e-2)" "unprognostic (1.08e-1)" "unprognostic (2.93e-2)" 8.6 1.7 0.7 5.6 0.7 4.9 8.0 0.7 1.4 6.4 0.8 15.2 10.2 3.2 1.4 11.9 3.8 5.4 4.1 0.7 0.7 6.2 1.7 8.1 7.7 1.2 0.8 0.7 7.9 0.8 1.2 3.2 1.1 3.4 11.0 0.0 8.9 1.5 1.5 6.5 18.3 2.1 0.8 18.6 10.6 1.1 1.1 3.5 10.7 1.3 7.6 5.4 7.5 1.1 0.0 0.0 0.0 0.0 2.4 2.7 0.0 0.6 3.4 0.0 0.0 0.1 7.0 0.1 1.7 0.3 0.0 1.6 0.0 0.1 0.0 4.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 1.2 1.1 0.0 0.1 0.0 0.0 0.0 0.5 0.0 10.1 0.0 0.0 0.0 1.2 1.2 0.0 0.0 0.0 0.0 11.1 0.0 0.0 1.9 2.9 1.5 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 1.6 0.0 1.7 3.3 4.2 3.7 5.1 3.9 2.1 3.1 3.7 3.3 2.4 1.6 2.3 1.9 2.7 6.0 1.6 6.1 2.9 0.7 0.7 0.7 1.4 0.7 0.7 1.2 0.8 1.1 0.8 1.1 1.1 5.5 3.2 9.1 0.0 5.7 1.5 1.4 5.8 1.8 0.0 2.0 0.9 0.7 2.8 4.7 3.7 0.0 0.3 9.6 38.5 3.9 8.1 0.1 3.2 0.8 4.2 6.1 1.3 0.0 35.2 0.4 1.9 22.4 5.4 12.6 0.0 0.7 0.0 12.7 0.0 0.0 14.4 4.1 9.5 1.6 0.3 0.0 7.7 3.6 1.9 11.6 0.0 10.3 0.0 0.0 17.8 21.4 0.0 5.5 0.5 22.5 0.1 3.7 0.0 0.0 0.2 1.0 0.0 0.3 3.9 1.4 0.3 8.3 0.1 8.0 3.3 RIPK4 "ANKK2, ANKRD3, DIK, PKK, RIP4" ENSG00000183421 "Receptor interacting serine/threonine kinase 4" P57078 21 41739369-41767089 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Disease variant, Ectodermal dysplasia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 72.2" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 52.3;Endometrial ciliated cells: 76.5;Gastric mucus-secreting cells: 61.2;Glandular and luminal cells: 174.2;Squamous epithelial cells: 71.2" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CAPAN-2: 32.2;GAMG: 41.2;HaCaT: 47.5;hTCEpi: 31.4;RPTEC TERT1: 28.3;RT4: 30.8" "Low region specificity" "Detected in single" "Low region specificity" "Detected in some" HPA030942 Enhanced NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 44: Endometrium - Transcription" "HPA030942: AB_2732462" "unprognostic (8.93e-2)" "unprognostic (2.67e-1)" "unprognostic (6.32e-3)" "unprognostic (7.87e-2)" "unprognostic (1.24e-1)" "unprognostic (5.61e-2)" "unprognostic (1.30e-1)" "unprognostic (2.88e-2)" "unprognostic (1.02e-1)" "prognostic unfavorable (6.22e-5)" "prognostic unfavorable (3.48e-4)" "unprognostic (9.98e-2)" "prognostic favorable (6.52e-4)" "unprognostic (2.69e-1)" "unprognostic (2.95e-3)" "unprognostic (2.28e-1)" "unprognostic (2.78e-2)" 1.6 0.0 0.1 0.4 0.0 0.6 4.3 0.0 0.1 11.8 3.7 3.1 9.7 1.1 2.4 72.2 5.8 5.2 1.5 0.1 0.1 11.5 19.1 4.2 0.1 0.3 0.6 0.1 14.3 7.4 10.8 2.3 0.1 10.7 2.0 0.6 14.8 9.8 0.0 21.5 13.6 0.1 0.1 0.0 15.5 2.0 0.1 7.8 7.9 0.0 5.2 6.3 22.3 0.1 14.3 9.0 0.0 0.0 0.0 0.0 13.7 0.1 0.1 0.2 0.2 23.5 32.2 0.0 13.3 2.9 41.2 47.5 0.7 19.2 0.0 0.0 9.4 0.0 6.9 8.8 0.0 0.0 0.0 0.0 31.4 0.2 4.2 0.0 0.0 14.3 0.0 0.0 0.0 10.3 2.0 0.0 0.8 9.3 26.1 0.0 0.0 2.3 28.3 30.8 4.5 0.3 15.5 15.7 15.1 1.3 9.6 0.0 0.0 0.2 0.1 0.0 0.2 0.0 0.0 0.0 4.2 0.0 11.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.1 0.3 0.6 0.1 0.1 0.1 0.1 0.1 28.9 9.1 0.0 0.1 15.8 27.4 24.0 52.3 0.0 13.0 12.4 1.1 17.2 28.0 3.7 0.0 8.3 0.3 22.8 9.8 12.4 1.5 76.5 16.9 0.9 22.7 0.0 0.0 10.4 5.1 0.6 61.2 174.2 2.5 0.0 0.0 17.0 1.0 0.0 0.0 14.2 16.2 0.6 1.4 1.6 0.0 0.9 7.2 0.0 0.0 0.4 0.0 0.0 0.0 19.0 11.8 0.0 0.0 24.0 26.5 13.5 22.2 0.9 0.0 0.0 1.3 1.4 2.5 71.2 15.2 2.5 1.5 0.0 11.2 24.1 RNF103 "hkf-1, KF1, ZFP103" ENSG00000239305 "Ring finger protein 103" O00237 2 86603398-86623866 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 7.2" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA057922 Approved NA NA "Cluster 46: Basophils - DNA binding" "Cluster 15: Liver - Metabolism" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 35: Glandular cells - Unknown function" "HPA057922: AB_2683555" "unprognostic (4.41e-1)" "unprognostic (1.56e-1)" "unprognostic (6.04e-2)" "unprognostic (3.26e-1)" "unprognostic (3.20e-2)" "unprognostic (1.79e-1)" "unprognostic (7.42e-2)" "unprognostic (8.37e-2)" "unprognostic (4.06e-1)" "unprognostic (1.13e-2)" "unprognostic (6.21e-2)" "unprognostic (1.44e-1)" "unprognostic (3.54e-3)" "unprognostic (1.50e-1)" "unprognostic (1.77e-1)" "unprognostic (3.67e-2)" "prognostic favorable (6.77e-5)" 14.6 15.3 25.7 9.0 28.8 13.6 20.9 35.8 31.6 15.9 22.6 21.9 18.7 23.7 45.4 14.0 16.9 19.4 37.7 24.8 25.1 15.3 54.5 11.3 8.1 26.8 27.2 16.0 24.7 25.2 15.6 15.6 25.7 23.3 16.5 10.3 18.7 17.7 21.4 14.3 23.0 21.0 27.2 10.5 22.6 15.4 26.7 8.1 10.2 19.1 10.0 14.4 13.9 30.6 9.6 12.9 6.4 9.9 28.6 18.3 10.3 13.6 20.6 6.8 9.2 7.5 16.1 15.9 15.9 20.4 24.8 11.5 8.7 10.7 10.2 13.4 11.7 9.1 5.4 16.7 27.1 3.0 13.0 26.9 21.8 10.1 12.6 24.3 20.7 7.4 3.3 9.3 19.0 11.9 7.0 8.0 2.9 19.0 9.0 4.3 27.5 9.4 25.1 14.9 10.2 10.4 16.0 35.2 14.0 8.0 13.5 7.4 23.6 13.2 6.3 13.4 8.2 32.3 11.5 10.7 10.5 5.1 6.5 4.5 0.5 7.2 0.7 0.7 1.0 0.9 1.1 1.6 1.1 1.0 1.2 0.9 1.0 2.3 0.4 0.8 2.5 0.6 25.7 28.8 35.8 31.6 24.8 25.1 26.8 27.2 25.7 27.2 26.7 30.6 22.6 9.6 14.5 0.0 16.6 48.3 35.5 13.9 33.6 15.8 45.9 31.1 40.0 31.5 22.1 20.2 4.2 13.6 15.7 72.4 1.9 17.6 16.8 20.4 17.9 22.4 31.8 16.4 0.0 28.4 7.8 27.6 44.4 30.0 18.4 19.9 22.9 68.9 9.6 18.5 0.0 45.9 12.2 14.1 29.5 9.3 25.4 19.8 10.6 0.0 8.0 17.2 2.1 0.0 0.0 33.9 41.5 23.0 41.1 45.0 56.1 12.9 33.6 9.5 6.6 40.3 25.7 27.5 12.6 32.6 44.2 40.9 19.5 9.0 24.3 48.6 RNF115 "CL469780, ZNF364" ENSG00000265491 "Ring finger protein 115" Q9Y4L5 1 145738868-145824095 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 6.4" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019130 Approved Approved Nucleoli,Mitochondria NA NA "Cluster 34: Basophils - Unknown function" "Cluster 38: Heart - Muscle contraction" "Cluster 3: HMC-1 - Innate immune response" "Cluster 24: Non-specific - Transcription regulation" "Nucleoli, Mitochondria" "HPA019130: AB_1859220" "unprognostic (3.44e-2)" "unprognostic (2.47e-3)" "unprognostic (2.24e-1)" "unprognostic (1.09e-1)" "unprognostic (5.48e-2)" "unprognostic (1.90e-1)" "prognostic unfavorable (2.95e-4)" "unprognostic (2.29e-2)" "unprognostic (1.46e-2)" "unprognostic (1.35e-1)" "unprognostic (2.64e-2)" "unprognostic (7.29e-2)" "unprognostic (1.44e-2)" "unprognostic (3.23e-1)" "unprognostic (4.77e-2)" "unprognostic (2.46e-2)" "unprognostic (1.08e-1)" 8.9 5.0 7.7 4.6 7.3 7.5 7.5 16.1 9.0 7.1 6.1 9.0 3.4 12.2 4.1 5.7 7.9 4.7 24.9 7.7 6.8 5.6 5.1 5.9 5.0 6.3 6.8 5.5 5.3 6.8 5.3 3.5 6.6 7.3 3.7 13.9 5.9 5.2 32.1 6.1 5.5 11.1 5.7 5.0 5.8 3.9 7.5 5.0 6.1 25.3 4.7 7.9 5.6 7.1 11.0 4.5 5.4 3.9 9.6 12.5 4.2 8.1 15.1 5.9 7.1 4.9 3.8 7.7 9.0 11.7 5.7 7.5 6.0 5.5 6.3 7.7 3.9 6.1 5.9 4.6 6.1 9.7 13.7 7.3 4.8 6.0 7.1 6.7 7.7 5.9 6.1 12.2 10.8 8.3 7.1 6.0 6.8 7.0 9.4 6.7 5.4 6.4 11.6 3.6 5.3 7.4 6.6 8.0 6.3 6.6 8.9 9.1 9.4 8.4 6.6 5.1 8.7 10.2 10.3 8.0 4.2 6.4 5.4 6.4 1.0 1.6 1.4 0.8 1.2 1.5 1.0 1.4 0.8 1.2 1.0 1.4 0.7 1.6 0.8 1.1 1.0 0.7 7.7 7.3 16.1 9.0 7.7 6.8 6.3 6.8 6.6 5.7 7.5 7.1 168.4 16.0 29.2 61.7 43.5 20.6 32.6 24.4 23.9 101.3 35.9 29.1 152.5 38.6 27.0 18.4 114.7 26.8 155.6 13.2 33.2 44.8 68.5 52.9 45.4 72.3 27.1 60.6 91.2 80.3 28.7 60.8 28.1 55.8 31.7 39.1 71.7 33.1 37.2 82.4 77.6 23.5 28.5 41.5 36.2 25.3 39.4 38.9 39.2 84.3 71.0 64.4 90.6 81.4 83.9 52.4 18.8 80.9 90.5 76.0 22.5 46.6 29.6 111.1 59.2 60.2 53.5 76.5 63.7 23.7 18.0 19.8 75.7 65.2 23.6 40.2 RNF123 "FLJ12565, KPC1" ENSG00000164068 "Ring finger protein 123" Q5XPI4 3 49689538-49721529 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 156.1;tongue: 112.0" "Cell type enhanced" "Detected in many" "Erythroid cells: 52.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA065983, HPA071879" Supported Approved Cytosol NA NA 140000 "Cluster 37: B-cells - Transcription" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 6: Erythroid cells - Oxygen transport" Cytosol "HPA065983: AB_2685592, HPA071879: AB_2686468" "unprognostic (2.68e-1)" "unprognostic (3.34e-1)" "unprognostic (2.67e-1)" "unprognostic (1.04e-1)" "unprognostic (2.21e-1)" "unprognostic (9.51e-2)" "unprognostic (2.04e-1)" "unprognostic (3.75e-1)" "unprognostic (4.08e-1)" "unprognostic (1.07e-1)" "unprognostic (7.51e-2)" "unprognostic (5.03e-3)" "prognostic favorable (1.33e-8)" "unprognostic (5.69e-2)" "unprognostic (1.74e-1)" "unprognostic (7.22e-2)" "unprognostic (3.83e-1)" 13.0 19.0 18.9 9.0 19.2 34.6 12.5 18.5 23.9 13.1 21.0 17.8 19.5 14.7 10.5 13.4 12.5 9.7 27.8 19.6 16.5 22.0 57.7 12.3 10.4 17.5 16.9 11.6 13.5 16.3 17.4 9.4 17.2 14.6 6.8 6.0 14.4 9.2 156.1 14.5 18.2 9.3 14.7 17.9 17.9 23.7 18.0 13.7 14.6 112.0 7.3 14.2 12.0 17.9 9.7 12.6 15.5 16.2 23.2 13.9 17.1 12.1 15.9 15.0 16.0 14.1 16.1 23.2 10.9 17.6 13.3 11.8 11.6 18.1 10.0 15.8 15.0 19.7 27.8 31.6 23.1 19.3 19.8 17.6 17.9 14.4 16.5 14.8 16.2 23.0 20.0 20.0 13.2 14.1 19.8 30.7 8.2 11.5 21.0 9.3 9.7 24.4 21.5 16.4 10.6 20.8 16.4 14.4 18.7 8.7 15.4 33.0 16.2 13.4 16.3 11.9 14.9 26.4 28.4 9.5 19.2 23.6 20.5 8.9 6.9 5.6 6.7 6.2 4.0 7.1 4.5 4.1 5.5 7.0 5.3 5.0 4.0 5.5 6.8 7.9 3.6 3.8 18.9 19.2 18.5 23.9 19.6 16.5 17.5 16.9 17.2 14.7 18.0 17.9 7.1 9.6 5.3 16.3 6.5 2.3 3.1 4.7 1.8 8.6 7.1 6.1 1.1 11.5 5.8 3.7 4.2 6.8 9.3 10.4 5.9 5.3 13.3 8.1 5.8 5.9 6.7 52.4 18.0 5.5 4.6 5.9 11.2 7.5 7.0 9.5 10.0 29.8 5.6 6.7 14.6 6.1 10.2 9.6 1.4 16.5 7.5 6.0 3.6 5.6 6.3 5.4 7.2 7.5 7.2 7.2 6.3 5.7 7.0 5.0 19.2 10.2 5.4 8.9 0.0 7.6 5.6 10.7 8.9 4.6 3.0 8.5 6.0 7.5 6.9 4.1 RNF125 FLJ20456 ENSG00000101695 "Ring finger protein 125" Q96EQ8 18 32018825-32073219 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Adaptive immunity, Immunity, Ubl conjugation pathway" Transferase "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 18.4" "Cell type enhanced" "Detected in many" "dendritic cells: 169.6;Early spermatids: 90.7;NK-cells: 160.6;Oligodendrocytes: 64.3;T-cells: 114.8" "Cancer enhanced" "Detected in all" "testis cancer: 8.6" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HMC-1: 51.5;SK-MEL-30: 13.2;U-937: 11.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041514 Uncertain Supported "Nucleoli,Golgi apparatus" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 3: HMC-1 - Innate immune response" "Cluster 24: Non-specific - Transcription regulation" "Golgi apparatus" Nucleoli "HPA041514: AB_10795596" "unprognostic (2.13e-2)" "unprognostic (2.05e-2)" "unprognostic (2.88e-1)" "unprognostic (3.93e-1)" "unprognostic (5.03e-1)" "unprognostic (4.50e-2)" "unprognostic (2.30e-3)" "unprognostic (6.15e-2)" "unprognostic (4.21e-2)" "unprognostic (3.24e-1)" "unprognostic (1.68e-1)" "unprognostic (4.35e-2)" "prognostic unfavorable (4.06e-4)" "unprognostic (2.99e-1)" "unprognostic (4.12e-1)" "unprognostic (1.82e-1)" "unprognostic (7.07e-3)" 10.2 1.3 2.0 5.2 3.7 18.4 6.3 2.7 2.7 3.9 1.6 5.0 10.5 2.9 0.5 2.5 3.4 3.3 2.6 1.9 2.3 1.0 12.5 4.7 7.0 3.6 3.2 1.4 3.1 1.7 0.3 3.7 3.4 1.8 6.4 0.3 2.2 1.4 2.3 4.9 11.3 3.3 2.6 5.9 3.4 1.0 3.8 5.3 1.4 2.9 4.0 3.0 1.7 6.2 1.2 0.1 0.2 0.4 0.5 0.8 1.0 0.1 0.0 0.0 0.0 0.1 2.5 0.1 1.2 0.1 0.4 0.9 1.6 1.2 0.2 6.6 2.6 0.3 0.4 0.3 0.1 8.9 51.5 1.6 2.4 0.0 2.8 0.3 0.4 2.7 0.1 1.9 0.1 2.0 2.3 8.2 4.2 8.9 1.5 9.2 0.6 0.2 0.5 0.5 0.9 0.3 0.2 0.1 13.2 1.6 1.3 4.2 0.2 0.1 0.7 0.1 0.1 5.9 0.2 0.1 0.6 11.5 6.9 13.3 4.5 4.5 15.0 2.5 9.9 2.5 12.0 12.8 4.2 2.3 9.5 12.3 1.9 15.5 2.8 4.3 13.7 6.9 2.0 3.7 2.7 2.7 1.9 2.3 3.6 3.2 3.4 2.6 3.8 6.2 62.2 3.2 5.8 3.3 16.3 9.8 3.1 1.0 14.2 0.8 5.3 3.7 2.1 4.3 3.8 12.9 0.0 0.4 169.6 24.6 1.9 1.0 90.7 4.9 2.1 28.4 1.2 15.8 2.7 1.8 0.1 5.3 8.6 13.4 18.9 0.2 12.5 25.1 10.5 0.0 3.0 8.3 0.0 19.2 12.6 17.4 2.8 18.4 1.8 30.9 23.8 0.7 160.6 3.5 64.3 1.1 4.5 0.0 49.9 2.7 41.4 4.5 1.7 0.9 0.0 3.2 3.2 0.5 1.8 5.8 6.8 0.8 114.8 0.2 14.7 2.4 RNF126 FLJ20552 ENSG00000070423 "Ring finger protein 126" Q9BV68 19 647526-663233 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043050 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm Cytosol "HPA043050: AB_10794768" "unprognostic (2.24e-1)" "unprognostic (1.64e-1)" "unprognostic (1.97e-1)" "unprognostic (2.48e-3)" "unprognostic (1.90e-1)" "unprognostic (2.32e-1)" "unprognostic (1.09e-3)" "unprognostic (3.57e-2)" "unprognostic (1.28e-1)" "unprognostic (1.70e-1)" "unprognostic (1.88e-2)" "unprognostic (2.68e-2)" "unprognostic (9.96e-3)" "unprognostic (7.04e-3)" "unprognostic (3.39e-2)" "unprognostic (2.05e-1)" "unprognostic (4.67e-2)" 21.2 23.4 11.8 16.0 13.0 21.8 21.7 10.8 19.4 19.1 3.8 26.6 21.6 20.8 2.7 42.3 19.1 4.6 25.9 13.4 9.7 20.7 40.2 19.3 14.1 13.2 10.3 16.8 23.0 6.8 20.2 8.8 13.1 20.2 4.9 4.3 21.0 7.0 61.6 45.3 27.2 4.9 10.2 30.6 24.3 49.4 11.9 10.1 14.7 12.8 5.8 21.6 24.0 16.6 79.7 26.5 21.0 30.6 4.8 6.7 38.5 40.6 15.0 22.5 21.2 52.1 26.9 64.2 25.9 16.5 8.9 51.7 12.6 30.0 6.2 43.8 98.8 32.7 24.5 47.0 18.2 64.9 46.0 11.3 22.9 18.5 14.3 9.0 20.6 51.8 68.5 63.4 12.0 62.9 67.7 35.0 62.4 22.5 50.6 48.9 18.1 102.0 17.0 43.6 52.0 42.1 30.1 39.8 42.4 7.2 25.3 51.5 28.6 40.6 30.6 62.1 71.1 112.3 59.5 77.6 52.1 39.2 43.0 3.7 14.7 12.3 25.1 18.4 21.1 23.9 23.1 24.7 19.0 25.5 17.7 16.6 3.7 27.7 22.6 21.5 28.3 14.8 11.8 13.0 10.8 19.4 13.4 9.7 13.2 10.3 13.1 10.2 11.9 16.6 34.2 12.8 7.4 9.1 66.9 137.9 61.2 44.3 45.5 31.4 35.7 39.6 27.6 27.1 23.2 9.2 16.7 72.8 74.8 60.9 54.8 60.6 146.4 20.2 17.8 31.0 21.7 37.8 11.9 75.6 139.2 29.3 40.2 22.7 14.7 23.1 22.9 22.9 43.2 32.0 9.9 39.3 26.4 26.7 58.9 36.8 21.5 32.9 42.7 3.7 47.5 32.7 112.3 7.1 15.7 136.2 70.0 19.5 76.5 98.2 68.1 40.8 14.8 24.6 59.2 22.0 40.5 153.6 65.3 74.4 144.8 88.1 60.7 43.2 58.1 87.0 RNF128 "FLJ23516, GRAIL" ENSG00000133135 "Ring finger protein 128" Q8TEB7 X 106693794-106797016 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 62.1;liver: 124.6" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 67.3;Cholangiocytes: 50.1;Distal enterocytes: 49.3;Gastric mucus-secreting cells: 54.6;Hepatocytes: 76.9;Proximal enterocytes: 85.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 41.9;CAPAN-2: 35.0;Hep G2: 30.6;OE19: 96.2;RPTEC TERT1: 30.5;RT4: 88.8;WM-115: 53.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019675 Uncertain NA NA "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 45: Enterocytes - Digestion" "HPA019675: AB_2670225" "unprognostic (1.78e-1)" "unprognostic (1.44e-2)" "unprognostic (1.23e-1)" "unprognostic (1.88e-3)" "unprognostic (1.92e-4)" "unprognostic (2.14e-3)" "unprognostic (2.37e-2)" "unprognostic (1.02e-1)" "unprognostic (2.06e-1)" "unprognostic (2.43e-2)" "unprognostic (1.55e-2)" "unprognostic (1.75e-2)" "prognostic unfavorable (1.07e-7)" "unprognostic (1.11e-2)" "unprognostic (7.61e-2)" "unprognostic (6.30e-2)" "unprognostic (5.30e-3)" 0.7 35.0 2.6 1.8 2.4 0.0 7.9 1.9 2.4 0.6 0.8 21.8 62.1 0.1 0.5 4.6 1.0 33.1 0.5 2.5 4.2 31.5 124.6 14.7 0.2 2.7 2.2 2.0 16.4 0.7 6.6 11.1 3.3 2.8 19.6 0.1 28.6 2.1 8.9 6.9 60.8 0.6 1.6 0.1 46.9 0.6 4.3 2.8 29.4 4.1 0.2 20.0 2.0 1.6 11.1 0.0 0.0 0.0 3.4 1.8 41.9 0.1 0.3 0.0 0.0 18.8 35.0 0.0 0.0 0.6 0.4 13.3 0.1 0.0 0.0 0.0 20.6 0.0 0.3 30.6 0.0 0.0 0.0 0.1 14.4 0.0 0.1 2.2 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 2.4 96.2 0.3 0.0 0.1 0.1 30.5 88.8 0.2 0.0 0.0 2.3 2.2 0.3 2.3 0.0 0.0 0.8 0.3 0.0 0.0 0.0 0.0 0.0 15.1 0.0 53.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 2.4 1.9 2.4 2.5 4.2 2.7 2.2 3.3 1.6 4.3 1.6 0.1 67.3 19.6 6.2 0.5 6.8 6.6 13.1 10.2 0.0 9.7 4.2 0.5 50.1 15.0 33.1 0.0 23.4 0.1 49.3 0.0 14.7 0.1 0.0 0.0 0.3 24.7 2.7 17.9 15.6 3.3 0.3 54.6 0.0 0.0 0.1 1.8 76.9 1.9 0.0 19.6 33.3 2.0 2.7 0.4 0.2 0.0 0.4 3.6 3.7 0.0 0.0 0.0 25.1 13.8 25.6 23.6 0.0 0.0 1.9 85.4 25.3 8.7 0.0 0.0 0.0 1.3 0.0 2.0 11.5 5.3 16.6 0.2 0.5 28.7 8.5 RNF13 RZF ENSG00000082996 "Ring finger protein 13" O43567 3 149812770-149962139 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 591.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 462.3" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA064784 Approved Supported Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 21: Non-specific - Transcription" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 4: Macrophages - Innate immune response" "Nucleoplasm, Vesicles" Cytosol "HPA064784: AB_2685350" "unprognostic (1.27e-1)" "unprognostic (2.32e-2)" "unprognostic (1.03e-1)" "unprognostic (1.93e-2)" "unprognostic (1.80e-1)" "unprognostic (9.64e-2)" "unprognostic (8.49e-2)" "unprognostic (4.36e-3)" "unprognostic (1.72e-1)" "unprognostic (1.25e-1)" "unprognostic (6.94e-3)" "unprognostic (1.13e-1)" "prognostic favorable (2.00e-8)" "unprognostic (2.95e-1)" "unprognostic (4.11e-2)" "unprognostic (2.17e-1)" "unprognostic (1.79e-1)" 48.2 41.2 58.1 40.4 95.2 19.9 53.9 88.1 91.5 33.6 63.7 35.0 28.9 33.3 57.2 32.6 30.2 40.6 34.4 55.0 77.3 67.9 73.8 64.1 38.0 101.8 83.9 35.6 36.1 52.3 18.3 64.1 100.8 46.6 37.1 40.4 75.5 39.3 36.5 32.5 30.5 36.9 85.6 53.0 34.3 25.2 75.9 32.0 64.0 42.6 33.2 42.3 28.9 131.0 60.6 39.4 24.4 29.0 92.2 55.2 40.3 32.2 86.2 32.3 47.4 33.4 84.4 26.6 48.7 42.0 58.7 58.0 37.5 41.5 42.9 34.1 24.6 35.8 17.3 31.2 61.5 35.0 41.8 59.9 73.1 26.5 71.8 37.3 37.0 24.9 10.1 49.7 28.0 34.5 26.2 18.8 16.8 58.6 29.1 19.0 26.7 108.5 54.2 29.6 12.6 37.6 28.5 39.9 110.3 19.2 79.2 34.0 37.8 40.8 16.5 45.6 23.4 89.9 61.9 51.5 35.9 30.1 23.6 98.2 130.1 106.5 37.4 153.8 48.8 51.9 41.5 44.8 93.1 48.4 38.0 42.4 462.3 46.3 207.8 68.3 48.7 104.5 58.1 95.2 88.1 91.5 55.0 77.3 101.8 83.9 100.8 85.6 75.9 131.0 100.9 109.0 72.3 78.7 55.3 73.5 68.2 84.3 74.0 44.5 54.5 51.1 27.3 48.6 68.1 47.8 29.2 101.2 61.9 30.2 43.0 63.0 2.5 32.5 34.5 69.4 20.3 32.4 122.1 70.6 83.5 84.8 31.6 39.7 60.8 14.6 80.3 53.7 201.2 21.9 98.8 27.7 67.1 183.9 173.7 6.7 76.1 177.6 103.2 92.8 93.5 98.5 38.1 115.6 591.2 58.7 33.6 88.0 62.4 71.9 38.5 71.5 40.4 37.2 92.1 76.3 55.5 23.6 32.5 52.3 72.5 52.5 49.8 38.2 27.7 55.8 RNF130 "G1RZFP, GOLIATH, GP" ENSG00000113269 "Ring finger protein 130" Q86XS8 5 179911651-180072113 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hofbauer cells: 295.7;Kupffer cells: 393.7;Macrophages: 283.0;monocytes: 276.4;Oligodendrocytes: 514.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 8 "basophil: 261.6;classical monocyte: 513.2;eosinophil: 331.3;intermediate monocyte: 355.0;myeloid DC: 407.4;neutrophil: 890.5;non-classical monocyte: 328.7;plasmacytoid DC: 317.2" "Group enriched" "Detected in all" 11 "dendritic cells: 407.4;granulocytes: 890.5;monocytes: 513.2" "Cell line enhanced" "Detected in many" "HMC-1: 179.3" "Low region specificity" "Detected in all" HPA014499 Approved NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 15: Liver - Metabolism" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 10: Non-specific - Unknown function" "HPA014499: AB_1856328" "unprognostic (2.01e-1)" "prognostic favorable (6.32e-4)" "unprognostic (2.43e-1)" "unprognostic (1.37e-1)" "unprognostic (2.24e-1)" "unprognostic (1.62e-2)" "unprognostic (2.83e-1)" "unprognostic (2.02e-3)" "unprognostic (2.93e-2)" "unprognostic (1.78e-1)" "unprognostic (4.00e-2)" "unprognostic (2.81e-1)" "unprognostic (1.14e-1)" "unprognostic (8.41e-2)" "unprognostic (4.17e-2)" "unprognostic (4.32e-1)" "unprognostic (1.38e-2)" 94.2 43.4 79.7 47.7 103.2 94.0 50.2 102.3 114.1 55.5 75.5 40.1 28.1 42.1 35.6 26.4 46.8 55.9 36.2 81.4 85.8 49.4 167.1 62.6 39.2 112.8 94.6 52.2 64.2 28.0 16.6 48.4 110.6 35.1 41.9 14.3 84.6 60.2 33.2 14.6 32.6 52.6 98.4 51.8 34.7 17.5 92.3 17.7 32.3 53.7 25.8 51.6 19.3 138.2 32.7 26.8 125.5 110.9 117.4 54.5 21.9 20.9 29.1 24.1 25.3 8.4 31.8 0.1 69.6 47.5 47.7 3.0 81.5 49.7 26.0 0.3 54.6 57.7 11.8 25.4 27.3 14.9 179.3 52.2 25.9 2.3 15.3 65.6 42.3 57.3 9.7 0.4 27.0 71.0 28.7 68.8 32.7 6.7 33.8 65.9 27.9 0.1 38.7 7.4 68.4 28.8 43.2 34.4 126.5 45.7 40.8 38.6 36.6 50.6 18.9 38.8 27.1 0.4 24.1 6.2 7.7 132.0 41.2 261.6 513.2 331.3 25.4 355.0 21.7 15.8 10.9 12.3 407.4 15.8 12.4 13.6 890.5 53.6 328.7 317.2 1.6 323.8 79.7 103.2 102.3 114.1 81.4 85.8 112.8 94.6 110.6 98.4 92.3 138.2 75.0 19.2 21.4 119.1 22.4 14.1 22.6 27.0 12.5 26.9 55.0 45.5 35.1 81.5 34.7 42.3 52.1 11.2 123.7 26.9 23.5 56.8 11.8 49.0 38.8 48.3 16.3 69.2 119.0 76.5 16.6 57.9 25.5 38.3 82.9 28.9 47.5 147.0 295.7 6.7 144.0 36.1 36.7 393.7 170.7 24.2 36.7 283.0 32.0 141.5 276.4 21.8 28.8 242.8 514.2 41.6 32.1 48.2 11.7 27.2 32.6 52.0 56.3 20.3 46.0 32.4 48.5 13.2 32.9 10.9 12.9 8.8 26.2 33.7 52.9 23.3 RNF133 ENSG00000188050 "Ring finger protein 133" Q8WVZ7 7 122697735-122699117 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "testis: 42.2" "Group enriched" "Detected in some" 146 "Early spermatids: 479.8;Late spermatids: 837.4" "Not detected" "Not detected" "Region enriched" "Detected in some" 5 "cerebellum: 7.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 31: Spermatids - Spermatogenesis" "unprognostic (2.82e-1)" "unprognostic (2.52e-2)" "unprognostic (1.77e-1)" "unprognostic (3.04e-2)" "unprognostic (2.45e-3)" "unprognostic (1.67e-1)" "unprognostic (8.87e-3)" "unprognostic (3.56e-2)" "unprognostic (3.72e-1)" "unprognostic (3.29e-3)" "unprognostic (1.26e-1)" "unprognostic (1.02e-2)" "unprognostic (7.76e-2)" "unprognostic (1.10e-1)" "unprognostic (2.39e-1)" "unprognostic (2.37e-2)" "unprognostic (7.61e-2)" 0.2 0.1 0.0 0.0 0.1 0.0 0.2 7.0 1.3 0.2 0.1 0.0 0.0 0.8 0.1 0.0 0.2 0.1 0.1 0.1 0.1 0.2 0.1 0.3 0.0 0.0 0.2 0.1 0.2 0.0 0.1 0.0 0.4 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 42.2 0.2 0.0 0.2 0.0 0.0 0.1 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.3 0.0 0.0 0.2 0.1 0.2 0.0 0.0 0.2 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 7.0 1.3 0.1 0.1 0.0 0.2 0.4 0.0 0.2 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 479.8 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 837.4 2.8 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.5 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 RNF138 "NARF, STRIN" ENSG00000134758 "Ring finger protein 138" Q8WVD3 18 32091874-32131561 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway, Wnt signaling pathway" "DNA-binding, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 96.0;testis: 119.3" "Group enriched" "Detected in many" 15 "Early spermatids: 982.8;Late spermatids: 3827.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041101 Approved Mitochondria NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" Mitochondria "HPA041101: AB_10805837" "unprognostic (2.37e-2)" "unprognostic (4.63e-3)" "unprognostic (2.03e-3)" "unprognostic (1.01e-1)" "unprognostic (2.34e-1)" "unprognostic (2.93e-2)" "unprognostic (1.47e-2)" "unprognostic (9.64e-2)" "unprognostic (1.29e-2)" "unprognostic (1.90e-2)" "unprognostic (6.90e-2)" "unprognostic (1.27e-2)" "unprognostic (6.15e-2)" "unprognostic (9.52e-3)" "unprognostic (2.77e-1)" "unprognostic (9.58e-2)" "unprognostic (1.90e-1)" 13.7 7.3 7.6 17.4 9.3 96.0 14.5 13.8 11.9 12.4 10.7 23.5 16.7 14.3 8.5 14.9 19.4 13.6 5.9 6.9 8.7 9.7 21.6 13.3 24.2 8.0 8.6 14.9 16.4 11.2 7.5 15.3 8.5 10.5 20.2 8.9 9.9 7.9 6.9 8.8 17.3 11.6 8.3 21.6 14.2 119.3 8.2 28.9 11.8 6.8 19.8 13.3 8.6 12.4 28.3 16.4 66.4 33.2 8.5 17.5 37.6 28.3 15.8 34.7 39.8 19.4 19.3 67.9 34.3 18.6 22.3 28.9 35.1 31.9 47.1 37.7 58.8 53.5 19.2 24.1 33.3 149.3 45.3 17.1 31.3 38.3 53.8 19.9 35.9 59.3 74.7 27.0 22.7 26.6 101.1 66.5 74.4 48.4 22.6 102.5 41.7 39.3 31.9 20.7 75.0 37.5 37.7 21.7 30.1 30.2 14.0 62.2 27.8 41.5 30.5 10.3 32.2 44.4 64.5 117.9 22.6 81.6 41.5 25.0 64.4 63.3 25.0 48.7 32.2 34.6 54.5 35.9 62.5 39.2 102.8 66.9 64.7 42.8 42.0 26.6 44.3 68.3 7.6 9.3 13.8 11.9 6.9 8.7 8.0 8.6 8.5 8.3 8.2 12.4 27.9 16.0 19.7 15.3 65.9 69.3 33.7 11.8 71.2 6.7 32.4 18.0 8.3 24.3 16.8 16.5 0.0 28.3 51.6 43.0 17.6 17.6 982.8 35.6 20.4 29.4 29.9 48.8 25.9 18.4 21.6 21.3 26.0 28.7 22.8 8.4 22.5 16.8 24.8 8.4 28.0 20.8 20.3 25.5 52.3 3827.9 29.5 34.7 26.6 23.4 27.1 9.9 20.6 22.6 36.4 12.9 23.9 22.2 32.4 32.7 16.4 14.5 23.0 5.2 32.9 23.1 26.0 158.1 128.3 51.4 52.1 8.9 59.3 9.9 29.9 37.5 RNF139 "HRCA1, RCA1, TRC8" ENSG00000170881 "Ring finger protein 139" Q8WU17 8 124474880-124488618 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Ubl conjugation pathway" "Receptor, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 93.2" "Group enriched" "Detected in all" 10 "Early spermatids: 810.1;Late spermatids: 992.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001202 Approved NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 34: Spermatids - Unknown function" "HPA001202: AB_1079824" "unprognostic (3.28e-3)" "unprognostic (2.92e-2)" "unprognostic (5.16e-2)" "unprognostic (5.43e-2)" "unprognostic (1.03e-1)" "unprognostic (8.32e-3)" "unprognostic (2.71e-2)" "unprognostic (2.00e-1)" "unprognostic (1.69e-1)" "unprognostic (1.51e-1)" "prognostic unfavorable (3.54e-4)" "unprognostic (9.85e-2)" "unprognostic (1.53e-2)" "unprognostic (1.62e-1)" "unprognostic (2.75e-1)" "unprognostic (7.75e-2)" "unprognostic (1.45e-1)" 23.5 20.8 10.0 15.9 11.1 93.2 18.9 14.8 12.7 16.6 11.2 15.6 9.2 20.2 13.6 16.5 16.7 16.8 15.3 11.0 11.0 15.3 26.1 16.6 17.3 11.0 10.8 23.6 14.4 11.8 10.2 19.4 11.0 14.9 14.8 12.4 16.5 13.3 20.3 17.2 14.2 20.3 11.8 13.9 13.9 68.7 11.7 19.3 16.3 22.6 14.8 16.7 12.4 15.0 26.6 17.1 21.6 20.3 43.2 34.1 16.6 23.5 44.4 18.6 24.7 10.9 21.6 27.5 27.8 31.7 14.3 19.7 18.3 28.4 28.9 37.6 24.5 41.1 11.9 22.9 33.3 19.6 23.2 30.5 41.0 20.5 55.9 27.1 26.2 26.8 29.1 41.3 22.2 70.2 32.9 13.6 14.3 52.6 25.6 13.2 14.9 27.0 35.3 34.4 9.4 22.3 31.0 76.5 33.4 16.5 35.7 20.7 20.6 13.9 29.7 22.2 26.3 32.9 40.9 28.6 19.9 31.7 13.9 2.7 6.2 10.1 8.7 4.1 11.0 7.9 7.8 10.5 8.4 7.1 8.1 8.4 8.5 7.2 11.4 4.0 11.4 6.7 10.0 11.1 14.8 12.7 11.0 11.0 11.0 10.8 11.0 11.8 11.7 15.0 21.1 3.2 8.4 11.8 66.2 66.2 62.1 27.2 58.6 14.5 31.6 19.7 16.2 34.3 18.5 22.0 6.2 42.3 58.5 22.5 11.7 19.9 810.1 31.3 22.6 24.9 21.7 27.1 12.9 18.0 55.9 40.1 23.4 37.1 20.3 23.2 22.9 31.8 25.0 16.8 12.8 18.5 10.2 33.7 74.4 992.2 29.5 43.4 35.6 12.2 26.5 21.3 26.8 8.5 18.5 22.5 11.4 27.1 35.4 41.1 17.0 16.9 20.1 22.7 19.7 39.7 49.2 62.3 24.3 46.7 70.5 75.5 83.5 22.6 18.2 55.5 RNF14 "ARA54, HFB30, TRIAD2" ENSG00000013561 "Ring finger protein 14" Q9UBS8 5 141958328-141990292 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 257.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008716, HPA064746" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 34: Basophils - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 23: Spermatids - Flagellum & Golgi organization" Nucleoplasm Cytosol "HPA008716: AB_1856337, HPA064746: " "unprognostic (7.45e-3)" "unprognostic (1.38e-1)" "unprognostic (8.56e-2)" "unprognostic (1.20e-1)" "unprognostic (3.47e-2)" "unprognostic (7.24e-3)" "unprognostic (2.35e-1)" "unprognostic (4.05e-2)" "unprognostic (5.22e-2)" "unprognostic (7.42e-2)" "unprognostic (7.92e-2)" "unprognostic (1.46e-1)" "prognostic favorable (1.71e-4)" "unprognostic (6.89e-3)" "unprognostic (2.82e-1)" "prognostic unfavorable (2.21e-4)" "unprognostic (1.06e-2)" 48.4 51.8 31.5 26.0 32.7 20.2 45.6 32.7 42.8 36.6 30.6 40.7 33.2 33.6 43.2 32.6 29.7 32.6 71.2 33.3 35.6 65.3 67.6 30.2 32.3 35.3 38.2 32.3 37.2 104.0 23.7 39.8 36.3 44.0 41.2 40.4 37.1 40.2 66.7 23.5 36.4 43.3 33.4 28.9 35.4 74.5 36.5 36.7 55.1 85.8 33.7 32.1 23.4 33.7 38.3 62.5 43.1 85.1 75.7 78.8 29.0 76.8 42.6 52.8 58.1 52.4 43.4 67.1 87.5 79.3 79.4 20.6 55.6 75.4 47.0 51.1 48.5 42.9 30.2 24.0 83.2 47.7 36.9 59.7 64.9 70.3 87.6 45.6 66.2 46.0 53.0 91.7 109.4 45.7 46.6 15.3 18.3 46.2 71.0 30.2 47.8 73.8 71.7 65.2 47.5 38.3 67.3 121.3 133.2 47.8 85.0 36.7 69.3 69.6 22.6 33.2 74.0 56.8 72.1 61.8 59.7 57.4 87.9 79.6 22.0 23.2 26.9 26.9 26.0 19.5 23.2 26.9 27.4 18.1 17.6 25.9 5.5 30.1 33.9 28.9 29.1 19.7 31.5 32.7 32.7 42.8 33.3 35.6 35.3 38.2 36.3 33.4 36.5 33.7 18.1 9.6 19.3 12.7 12.5 10.7 15.9 19.6 11.4 20.2 18.4 15.0 45.4 11.5 18.1 22.0 16.7 29.1 13.3 22.9 68.4 29.2 257.1 14.1 20.8 21.7 15.0 59.1 25.1 24.9 26.1 18.2 18.3 16.4 22.2 32.0 20.7 33.1 24.5 23.5 22.9 14.9 24.4 29.7 10.4 39.3 19.3 17.1 32.0 13.1 14.8 28.7 29.9 15.6 18.6 26.3 14.0 33.4 13.5 19.2 28.3 50.5 15.8 16.3 39.5 15.8 23.0 38.7 25.8 15.6 10.5 60.5 16.4 25.0 15.0 15.0 RNF144A "hUIP4, KIAA0161, RNF144, UBCE7IP4" ENSG00000151692 "Ring finger protein 144A" P50876 2 6917412-7068286 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 73.6" "Cell type enhanced" "Detected in many" "Excitatory neurons: 176.6;Inhibitory neurons: 101.7;Oligodendrocyte precursor cells: 194.5;Oligodendrocytes: 330.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 6.1" "Group enriched" "Detected in many" 7 "granulocytes: 6.1;T-cells: 2.4" "Cell line enhanced" "Detected in many" "HEL: 39.7;HMC-1: 127.9;SH-SY5Y: 39.0;SK-MEL-30: 39.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049939 Approved Supported Vesicles NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 3: HMC-1 - Innate immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Vesicles "HPA049939: AB_2680960" "unprognostic (1.78e-1)" "unprognostic (2.53e-3)" "unprognostic (8.37e-2)" "prognostic unfavorable (6.00e-4)" "unprognostic (6.57e-2)" "prognostic favorable (6.96e-4)" "unprognostic (7.04e-6)" "unprognostic (1.20e-1)" "unprognostic (2.03e-2)" "unprognostic (5.64e-1)" "unprognostic (9.11e-2)" "unprognostic (1.92e-1)" "unprognostic (1.03e-1)" "prognostic unfavorable (7.32e-5)" "unprognostic (1.30e-2)" "unprognostic (3.01e-1)" "unprognostic (1.82e-3)" 9.7 28.5 21.1 4.1 46.1 13.9 10.1 59.2 36.7 24.2 1.2 5.7 2.6 26.3 7.7 4.3 7.8 7.1 8.1 17.5 24.0 7.3 1.3 5.4 6.0 30.1 27.0 19.3 30.7 38.1 12.9 5.9 33.4 9.1 5.3 23.0 4.6 6.4 9.6 5.4 3.8 11.6 21.5 23.0 2.6 4.7 30.3 7.5 3.4 10.1 5.6 4.4 7.5 73.6 0.8 5.8 30.1 6.2 6.6 13.6 23.0 0.2 0.0 1.1 2.8 0.1 0.7 2.9 3.3 0.3 8.7 0.7 10.0 0.0 0.0 1.6 2.6 39.7 0.3 11.8 0.3 0.7 127.9 21.7 0.1 2.2 0.0 0.0 0.0 9.9 17.3 0.6 0.0 4.9 20.6 1.7 11.0 0.7 13.6 15.9 21.8 2.6 1.0 10.2 9.9 39.0 0.5 4.0 39.8 3.9 1.7 2.6 0.1 3.9 10.0 10.7 4.5 10.4 3.5 0.1 14.7 8.7 14.3 1.3 0.0 6.1 1.2 0.0 1.8 0.0 1.3 0.9 0.1 0.1 2.4 1.7 0.3 0.5 0.0 0.0 0.6 0.4 21.1 46.1 59.2 36.7 17.5 24.0 30.1 27.0 33.4 21.5 30.3 73.6 27.8 3.2 4.2 34.3 2.4 2.4 0.7 0.0 1.8 4.6 2.5 2.5 11.5 2.8 1.9 0.0 75.0 2.4 5.3 15.4 1.9 3.3 5.5 6.1 15.4 13.9 25.4 18.5 176.6 5.8 3.1 10.4 2.6 10.7 8.9 31.5 23.2 1.1 4.9 10.1 101.7 2.7 0.0 1.0 1.7 14.2 4.4 1.7 24.9 17.8 1.2 7.6 10.3 194.5 330.3 3.0 11.1 10.5 3.1 3.0 2.0 0.3 1.5 39.8 0.0 16.1 5.2 1.8 6.6 5.2 1.6 1.1 9.8 19.1 2.7 1.7 RNF144B "bA528A10.3, IBRDC2, P53RFP" ENSG00000137393 "Ring finger protein 144B" Q7Z419 6 18387350-18468870 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 56.9" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 634.4;Langerhans cells: 296.9;Suprabasal keratinocytes: 1501.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "non-classical monocyte: 71.9" "Group enriched" "Detected in many" 9 "dendritic cells: 18.4;granulocytes: 36.7;monocytes: 71.9" "Cell line enhanced" "Detected in many" "Daudi: 192.8;hTCEpi: 59.1;HUVEC TERT2: 55.6;TIME: 56.1;U-698: 160.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB046013, HPA054127, HPA072469" Uncertain Approved Nucleoli,Mitochondria NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 41: Macrophages - Immune response" Nucleoli Mitochondria "CAB046013: AB_11126028, HPA054127: AB_2682391, HPA072469: " "unprognostic (2.24e-2)" "unprognostic (1.16e-1)" "unprognostic (1.56e-1)" "unprognostic (4.07e-2)" "unprognostic (2.55e-1)" "unprognostic (4.48e-3)" "unprognostic (5.89e-2)" "unprognostic (1.18e-2)" "unprognostic (6.55e-2)" "unprognostic (2.87e-3)" "unprognostic (2.44e-2)" "unprognostic (2.60e-1)" "unprognostic (1.34e-1)" "unprognostic (2.39e-1)" "unprognostic (3.91e-2)" "unprognostic (1.53e-1)" "unprognostic (1.21e-1)" 9.4 2.0 7.4 15.6 7.4 24.0 29.1 7.9 9.0 9.5 9.1 4.2 1.8 5.7 4.7 8.4 11.8 6.2 8.1 6.4 7.7 14.0 15.5 19.4 11.3 11.8 11.9 1.6 3.2 2.9 1.7 15.1 9.4 13.1 2.8 5.0 16.9 7.3 56.9 21.1 3.3 6.2 8.9 13.1 5.7 2.3 10.5 5.1 40.9 14.1 12.9 9.4 7.1 8.7 4.6 1.0 0.4 0.0 0.3 2.0 9.8 5.3 5.7 11.0 11.8 0.1 0.4 192.8 50.7 2.3 0.6 16.3 0.1 16.0 15.5 0.9 1.4 0.2 0.2 4.2 0.2 0.2 0.2 2.7 59.1 4.3 13.2 4.9 55.6 4.3 0.1 0.0 2.7 2.0 1.5 0.0 1.6 0.6 1.1 0.7 1.7 11.8 33.2 10.6 1.9 0.2 1.2 23.9 18.5 1.5 28.2 0.5 56.1 8.6 1.9 0.8 1.2 0.0 0.1 160.6 1.0 0.4 0.7 0.4 20.7 12.9 0.5 38.9 1.6 4.6 0.8 0.6 13.3 3.6 1.6 1.0 36.7 0.6 71.9 18.4 0.5 7.1 7.4 7.4 7.9 9.0 6.4 7.7 11.8 11.9 9.4 8.9 10.5 8.7 28.8 44.8 15.0 34.9 21.7 634.4 48.8 86.0 14.8 0.9 35.7 26.3 12.8 17.2 48.3 38.6 2.1 14.1 9.8 2.2 19.6 8.6 2.1 49.0 5.8 34.6 1.2 3.8 2.3 8.9 3.7 7.8 10.7 58.5 3.8 0.1 47.2 21.9 15.0 0.0 99.0 1.8 14.2 109.4 296.9 1.8 1.2 171.7 60.5 92.8 54.1 17.9 1.0 3.5 2.5 5.2 3.6 3.0 3.4 112.3 0.9 20.6 36.7 1.2 0.0 9.0 7.8 2.2 3.2 30.0 1501.1 1.5 4.9 0.1 2.3 42.6 RNF146 "dactylidin, dJ351K20.1, DKFZp434O1427" ENSG00000118518 "Ring finger protein 146" Q9NTX7 6 127266682-127288567 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway, Wnt signaling pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027158, HPA027209" Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" No No "Cluster 14: Monocytes - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane, Cytosol" Nucleoplasm "HPA027158: AB_10600772, HPA027209: AB_10602312" "unprognostic (8.22e-2)" "unprognostic (1.20e-2)" "unprognostic (1.21e-1)" "unprognostic (1.32e-1)" "unprognostic (1.38e-2)" "unprognostic (1.17e-2)" "unprognostic (1.37e-1)" "unprognostic (5.47e-3)" "unprognostic (1.87e-1)" "unprognostic (6.74e-2)" "prognostic favorable (5.26e-5)" "unprognostic (2.65e-2)" "prognostic favorable (7.32e-4)" "unprognostic (4.04e-2)" "unprognostic (1.29e-1)" "unprognostic (6.13e-2)" "unprognostic (2.15e-2)" 52.9 37.0 49.5 32.4 56.0 10.6 42.7 79.4 61.2 48.1 36.2 40.5 21.9 57.4 60.8 25.3 42.4 38.6 46.9 50.7 51.6 37.1 31.8 38.7 35.1 53.2 52.1 49.5 23.3 40.0 33.3 51.8 56.8 31.7 30.9 48.1 31.2 34.5 114.9 29.5 31.1 45.9 55.2 47.1 29.9 31.3 52.5 24.3 47.1 91.5 33.3 36.9 34.3 61.5 13.2 16.2 60.3 53.6 54.7 54.3 22.2 43.5 69.0 22.8 32.4 21.3 19.3 23.6 30.3 35.7 36.2 16.4 18.1 20.4 32.9 27.6 16.0 30.3 21.8 30.0 54.0 18.0 20.6 47.6 42.1 26.1 51.1 52.5 40.6 23.2 33.0 22.5 50.7 25.2 17.9 32.0 22.1 8.1 17.1 22.6 15.7 12.1 32.4 14.3 36.0 36.6 17.1 23.6 27.7 35.5 16.1 60.8 48.3 39.7 13.1 41.8 31.7 32.3 22.0 15.6 30.5 31.0 38.5 27.5 30.0 26.6 14.3 32.4 14.7 17.4 12.2 16.3 22.8 17.9 11.0 15.5 37.0 19.8 40.1 11.7 15.0 16.1 49.5 56.0 79.4 61.2 50.7 51.6 53.2 52.1 56.8 55.2 52.5 61.5 24.6 35.3 29.3 35.6 23.7 17.7 14.3 15.1 18.8 34.7 16.9 14.7 38.9 31.5 16.7 9.2 4.2 29.0 14.7 13.5 41.1 28.0 52.5 15.7 29.5 30.5 20.4 12.8 53.5 15.8 27.2 50.6 7.1 11.5 22.2 28.1 31.4 30.5 26.3 30.3 54.5 12.1 38.7 68.4 24.6 45.4 69.6 29.9 46.2 42.2 31.1 41.1 28.8 56.3 76.5 18.0 17.0 66.5 9.3 26.3 15.7 51.7 23.9 20.9 32.9 36.2 31.9 41.7 24.9 15.0 20.0 38.4 20.8 36.0 10.9 25.9 RNF149 FLJ90504 ENSG00000163162 "Ring finger protein 149" Q8NC42 2 101271219-101308701 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Kupffer cells: 278.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 5 "neutrophil: 619.9" "Lineage enriched" "Detected in all" 5 "granulocytes: 619.9" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011424 Approved Approved "Vesicles,Plasma membrane" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "Vesicles, Plasma membrane" "HPA011424: AB_1079825" "unprognostic (2.56e-2)" "unprognostic (4.70e-2)" "unprognostic (1.96e-1)" "unprognostic (3.49e-2)" "unprognostic (3.17e-2)" "unprognostic (5.17e-3)" "unprognostic (4.16e-2)" "unprognostic (4.77e-3)" "unprognostic (5.61e-2)" "unprognostic (1.43e-2)" "unprognostic (5.69e-3)" "unprognostic (1.51e-1)" "prognostic unfavorable (2.04e-8)" "unprognostic (1.39e-1)" "unprognostic (6.16e-2)" "unprognostic (2.70e-1)" "prognostic favorable (2.91e-4)" 26.7 15.2 7.7 40.3 7.5 52.3 16.3 7.7 9.7 17.7 12.3 15.7 16.8 12.4 16.3 35.5 16.9 18.9 12.5 7.6 8.9 16.3 26.6 30.5 18.3 9.9 8.5 15.9 22.3 17.9 10.4 21.8 9.6 12.6 15.8 7.8 18.3 10.1 8.5 25.6 18.2 12.9 8.5 53.1 19.1 15.8 9.1 15.2 12.2 9.4 19.6 29.1 22.7 10.9 19.9 11.4 8.8 11.3 31.6 31.3 49.7 24.0 31.8 32.1 35.8 29.0 51.6 6.1 28.3 23.9 42.9 39.0 12.5 24.6 29.7 16.9 16.6 12.4 9.9 50.0 42.1 13.4 19.2 28.9 40.0 37.9 25.1 24.7 58.9 13.0 10.7 18.0 32.4 16.9 18.8 14.0 6.1 27.1 20.0 11.5 14.2 23.4 38.0 48.0 11.5 8.5 14.4 36.0 37.2 9.5 9.7 17.8 39.6 16.2 9.1 24.5 5.3 35.5 22.5 0.2 5.2 18.6 12.2 44.0 73.6 90.3 43.8 118.1 41.8 13.2 40.0 45.3 27.9 8.5 28.2 30.2 619.9 15.3 134.1 52.5 53.8 69.8 7.7 7.5 7.7 9.7 7.6 8.9 9.9 8.5 9.6 8.5 9.1 10.9 19.9 48.1 48.1 44.7 55.2 76.9 78.1 63.5 54.7 20.4 29.7 15.9 13.0 41.5 48.4 55.2 56.3 65.2 112.4 53.1 1.9 59.1 97.9 41.8 31.9 30.0 8.5 22.7 82.8 42.2 73.0 53.5 37.2 63.1 39.2 17.3 27.1 46.2 85.9 8.4 71.6 31.7 12.2 278.6 144.2 37.2 30.7 209.0 40.9 50.6 116.5 11.6 61.8 34.7 59.6 54.3 52.3 19.5 125.5 73.5 45.9 25.8 44.8 20.7 59.2 40.5 30.1 36.6 40.3 128.3 91.6 128.1 115.7 23.8 32.8 154.1 RNF152 FLJ39176 ENSG00000176641 "Ring finger protein 152" Q8N8N0 18 61808067-61894247 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 48.3;choroid plexus: 62.3;kidney: 56.5" "Cell type enhanced" "Detected in many" "Hepatocytes: 96.4;Proximal tubular cells: 159.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HaCaT: 21.5;SH-SY5Y: 13.4;TIME: 14.2;U-138 MG: 21.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "unprognostic (3.30e-2)" "unprognostic (1.97e-2)" "unprognostic (1.64e-1)" "unprognostic (8.55e-3)" "unprognostic (2.05e-1)" "unprognostic (2.09e-1)" "unprognostic (2.96e-3)" "unprognostic (3.62e-1)" "unprognostic (1.51e-2)" "unprognostic (8.13e-2)" "unprognostic (5.14e-2)" "unprognostic (6.73e-2)" "prognostic favorable (1.13e-8)" "prognostic unfavorable (2.85e-5)" "unprognostic (3.26e-2)" "unprognostic (2.82e-2)" "unprognostic (4.83e-2)" 7.4 3.4 5.4 0.9 13.9 0.9 6.7 48.3 5.3 8.2 62.3 7.2 1.7 6.3 3.6 4.5 5.2 3.8 7.6 6.1 10.6 56.5 22.1 7.0 0.5 25.5 13.7 4.0 2.5 2.4 2.9 6.5 28.7 5.3 6.6 5.0 14.0 2.8 2.3 11.4 5.5 4.1 8.5 0.6 6.3 1.3 21.1 0.6 5.4 2.3 0.8 4.2 7.5 14.9 0.0 0.0 4.8 1.0 4.4 0.6 0.0 3.1 9.4 0.7 0.5 0.0 0.1 0.1 0.9 4.9 0.1 21.5 5.9 11.4 1.3 0.0 0.6 0.0 0.0 0.0 2.3 0.0 0.1 0.7 8.1 3.6 2.4 2.1 8.7 0.1 0.0 0.1 1.4 0.9 0.8 0.0 0.3 0.7 0.0 0.3 3.1 0.0 0.5 3.7 3.9 13.4 0.0 8.7 1.5 4.2 5.1 0.0 14.2 21.6 2.2 0.0 0.5 0.1 0.0 0.0 0.7 0.0 7.3 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 5.4 13.9 48.3 5.3 6.1 10.6 25.5 13.7 28.7 8.5 21.1 14.9 26.8 0.0 0.0 9.4 0.2 42.3 28.1 11.1 11.4 19.1 16.2 10.3 4.8 12.8 10.5 20.2 0.0 0.4 0.9 58.1 46.9 2.5 0.4 16.8 18.5 17.1 16.2 8.0 9.9 2.7 0.1 9.5 18.3 29.9 0.0 0.1 10.8 96.4 0.1 21.9 20.0 5.6 32.6 1.8 7.7 1.4 8.7 2.2 28.4 2.8 0.0 3.5 0.0 16.6 27.5 1.7 34.9 18.4 0.3 8.7 46.6 159.0 1.8 3.6 65.7 2.8 59.7 0.2 0.5 28.0 32.5 0.3 1.7 18.7 16.2 21.2 RNF167 DKFZP566H073 ENSG00000108523 "Ring finger protein 167" Q9H6Y7 17 4940008-4945222 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049810 Approved Approved "Vesicles,Mitotic spindle,Centriolar satellite,Cytosol" Yes NA "Cluster 5: Granulocytes - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 2: Karpas-707 - Immune response" "Cluster 63: NK-cells & T-cells - Immune response" "Vesicles, Cytosol" "Mitotic spindle, Centriolar satellite" "HPA049810: AB_2680894" "unprognostic (1.13e-1)" "unprognostic (5.12e-2)" "unprognostic (2.29e-3)" "unprognostic (1.63e-2)" "unprognostic (3.43e-2)" "unprognostic (7.32e-2)" "unprognostic (2.18e-1)" "unprognostic (6.77e-2)" "unprognostic (7.46e-2)" "unprognostic (2.07e-2)" "prognostic favorable (2.03e-6)" "unprognostic (2.16e-1)" "prognostic favorable (4.47e-4)" "unprognostic (7.62e-2)" "unprognostic (1.93e-1)" "unprognostic (3.26e-1)" "unprognostic (1.12e-1)" 75.0 110.6 141.9 53.0 146.7 69.0 73.1 146.4 179.9 93.2 138.6 111.5 66.6 94.9 76.4 122.1 84.3 45.3 131.8 141.5 146.4 106.7 184.2 77.5 64.5 146.3 145.4 87.4 115.1 105.8 96.8 50.7 146.3 95.0 65.7 98.1 92.5 70.5 152.9 127.8 100.5 52.8 142.4 113.8 111.8 110.6 150.3 98.1 93.4 94.2 71.6 106.7 90.4 153.3 102.6 143.1 61.1 73.7 132.8 68.7 92.7 63.4 76.1 119.7 93.4 96.2 43.3 71.5 120.3 93.5 63.9 147.5 103.2 114.8 86.1 74.5 166.1 121.9 164.4 94.9 100.6 59.0 245.0 79.6 176.5 129.8 116.2 74.6 77.2 101.0 49.9 237.5 96.2 66.3 92.8 70.6 75.4 102.0 86.8 62.8 61.9 91.5 137.3 77.4 49.2 61.1 56.0 92.9 81.9 83.1 87.3 55.9 49.5 76.6 48.3 66.8 119.3 79.5 88.0 23.7 98.4 80.6 77.9 108.4 88.8 236.9 195.3 94.0 153.4 100.4 148.0 195.7 73.9 98.7 103.2 152.2 219.8 118.8 117.7 75.9 153.0 177.0 141.9 146.7 146.4 179.9 141.5 146.4 146.3 145.4 146.3 142.4 150.3 153.3 36.9 0.0 3.9 12.4 54.3 68.6 44.4 65.8 51.8 43.2 56.6 44.7 15.8 77.2 38.9 49.7 20.9 120.1 64.7 65.2 56.7 78.5 59.6 29.8 25.1 36.4 31.8 60.6 11.3 66.7 139.7 36.3 36.2 32.2 14.0 26.3 45.7 95.1 58.4 18.5 11.2 45.7 65.1 41.3 43.6 86.5 48.7 36.1 39.2 6.5 53.1 46.9 114.4 10.1 17.9 60.7 44.9 53.8 59.1 32.6 108.2 64.0 31.1 32.3 39.5 28.4 35.1 127.1 106.7 61.4 83.3 125.2 82.5 37.2 59.6 48.0 RNF180 ENSG00000164197 "Ring finger protein 180" Q86T96 5 64165843-64372869 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "parathyroid gland: 25.3" "Cell type enhanced" "Detected in many" "Excitatory neurons: 90.5;Inhibitory neurons: 151.6;Oligodendrocyte precursor cells: 162.3" "Cancer enhanced" "Detected in many" "glioma: 7.6" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in some" 6 "RPMI-8226: 29.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006897 Approved Approved Cytosol NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 25: RPMI-8226 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "HPA006897: AB_1856348" "unprognostic (7.46e-2)" "unprognostic (3.90e-3)" "unprognostic (3.19e-2)" "unprognostic (8.62e-2)" "unprognostic (2.45e-1)" "unprognostic (2.72e-1)" "unprognostic (5.57e-2)" "unprognostic (2.38e-2)" "unprognostic (1.08e-1)" "unprognostic (1.69e-1)" "unprognostic (3.37e-3)" "unprognostic (3.68e-2)" "prognostic favorable (6.81e-5)" "unprognostic (2.01e-2)" "unprognostic (3.35e-2)" "unprognostic (1.81e-2)" "unprognostic (9.81e-3)" 5.4 5.1 3.2 1.5 3.9 0.3 3.6 2.6 5.1 4.1 2.9 3.3 1.7 7.7 7.7 4.2 4.9 4.2 7.0 2.8 8.2 8.1 4.5 3.7 1.3 3.9 5.8 7.6 4.2 25.3 3.5 0.6 4.7 7.3 1.3 6.0 4.6 10.6 2.7 4.1 1.4 5.7 4.4 3.0 2.6 3.4 6.6 0.7 14.0 4.1 0.9 3.3 2.3 4.5 0.0 0.1 1.4 0.0 0.0 0.0 0.3 1.2 0.5 1.2 0.7 0.0 0.1 0.0 0.1 0.9 0.7 0.2 0.0 0.5 0.2 0.0 0.1 0.4 0.0 0.0 0.5 0.0 0.3 0.1 3.0 0.0 0.1 4.8 0.0 0.0 0.0 0.0 2.5 0.4 0.0 0.0 0.6 0.0 1.4 0.1 3.7 29.4 2.1 0.3 0.3 0.1 0.0 0.3 0.0 1.8 1.5 0.1 0.1 0.0 3.5 0.1 3.3 0.0 0.0 0.0 0.6 0.0 3.9 1.2 0.6 1.7 0.6 0.2 0.9 0.5 1.0 1.1 0.2 0.8 1.4 1.3 1.0 0.8 0.3 0.4 0.7 0.0 3.2 3.9 2.6 5.1 2.8 8.2 3.9 5.8 4.7 4.4 6.6 4.5 9.5 16.0 12.3 51.6 0.5 4.6 8.9 1.3 7.4 16.6 8.1 4.2 10.9 10.0 4.9 16.5 14.6 0.0 0.0 0.0 7.9 5.8 12.5 14.2 6.1 6.3 1.2 0.0 90.5 2.6 0.1 7.9 6.1 32.9 0.0 5.7 14.3 5.9 0.1 11.8 151.6 1.9 0.0 0.6 1.1 8.8 34.5 0.5 5.4 32.8 0.0 30.1 0.0 162.3 50.1 3.1 2.7 25.2 0.0 6.4 1.2 15.9 1.9 16.9 39.5 24.2 20.4 18.9 12.0 2.9 7.4 0.0 0.3 4.1 1.6 4.5 RNF182 MGC33993 ENSG00000180537 "Ring finger protein 182" Q8N6D2 6 13924446-13980310 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 24.7;choroid plexus: 12.7" "Cell type enriched" "Detected in some" 4 "Astrocytes: 85.2" "Cancer enhanced" "Detected in many" "glioma: 5.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HeLa: 81.3;RPTEC TERT1: 67.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA012309 Approved Approved "Nucleoplasm,Golgi apparatus,Vesicles" NA NA "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 20: HeLa - Mitochondria" "Cluster 64: Astrocytes - Nervous system maintenance" "Nucleoplasm, Golgi apparatus" Vesicles "HPA012309: AB_1856349" "unprognostic (1.29e-1)" "unprognostic (1.06e-2)" "unprognostic (2.74e-1)" "prognostic unfavorable (4.66e-5)" "unprognostic (6.16e-2)" "unprognostic (2.08e-1)" "unprognostic (9.01e-2)" "unprognostic (6.12e-2)" "unprognostic (1.71e-2)" "unprognostic (4.21e-1)" "unprognostic (6.04e-2)" "unprognostic (1.42e-1)" "unprognostic (1.05e-1)" "unprognostic (9.33e-5)" "unprognostic (6.66e-3)" "unprognostic (1.33e-3)" "unprognostic (1.26e-1)" 1.1 0.1 12.2 0.1 13.3 8.4 0.6 22.5 17.7 0.8 12.7 0.2 0.2 0.6 1.1 0.3 1.2 0.2 0.3 17.6 12.2 1.1 0.0 3.3 0.2 16.9 17.7 0.3 1.7 5.8 1.8 1.3 16.5 0.4 0.1 8.8 1.3 2.1 0.2 0.4 0.3 0.3 14.2 0.2 0.2 3.7 24.7 1.5 1.3 0.1 0.0 0.3 0.4 12.2 0.2 6.5 12.0 0.0 4.1 5.0 0.7 6.3 8.6 17.0 16.4 0.3 0.1 0.0 0.1 6.8 18.5 0.0 14.3 0.1 30.9 0.0 4.7 0.4 81.3 0.0 0.0 0.1 0.0 2.8 0.0 26.3 0.2 19.5 0.3 3.5 0.5 0.0 11.9 0.2 0.1 2.2 6.9 0.1 23.9 3.8 2.9 1.0 67.3 0.0 14.2 13.7 0.6 0.0 24.8 4.4 0.0 2.4 6.5 20.7 4.4 0.2 14.3 0.0 0.0 0.0 14.1 0.0 30.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.2 13.3 22.5 17.7 17.6 12.2 16.9 17.7 16.5 14.2 24.7 12.2 0.2 0.0 0.0 85.2 0.1 0.3 0.1 0.0 0.0 19.3 0.2 0.0 0.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.9 1.6 0.4 0.1 0.2 0.0 9.7 8.6 0.0 0.1 0.4 0.0 0.1 0.0 5.4 0.0 0.1 0.1 15.2 1.5 0.1 0.0 0.0 0.3 1.4 0.3 0.0 0.0 5.6 0.0 14.7 0.0 2.5 0.4 0.1 0.0 0.0 0.0 0.1 0.0 1.1 0.1 1.3 6.6 0.0 1.3 5.7 3.2 0.0 0.0 0.3 0.3 0.0 0.1 0.1 RNF185 FLJ38628 ENSG00000138942 "Ring finger protein 185" Q96GF1 22 31160182-31207019 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Autophagy, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 1: Thyroid gland - Transcription" "Cluster 30: Epithelial cell lines - Translation" "Cluster 4: Macrophages - Innate immune response" "unprognostic (1.50e-1)" "unprognostic (1.04e-1)" "unprognostic (7.11e-2)" "unprognostic (2.33e-1)" "unprognostic (3.65e-3)" "unprognostic (4.76e-3)" "unprognostic (2.60e-3)" "unprognostic (1.12e-2)" "unprognostic (3.97e-1)" "unprognostic (2.56e-1)" "unprognostic (2.61e-1)" "unprognostic (9.41e-2)" "prognostic favorable (4.82e-5)" "unprognostic (3.04e-1)" "unprognostic (1.63e-1)" "unprognostic (2.86e-1)" "unprognostic (1.10e-1)" 19.8 18.7 21.5 14.4 22.5 10.1 22.8 21.7 25.1 22.3 22.5 23.4 20.5 22.5 25.1 25.9 23.0 16.4 21.1 22.5 22.1 36.2 48.4 19.0 16.2 21.7 22.0 26.1 19.2 48.8 15.8 21.0 22.0 38.2 22.2 16.5 30.2 28.7 23.4 29.9 21.9 25.6 21.9 16.6 21.7 10.8 23.2 21.0 52.0 25.5 21.3 24.2 23.0 23.6 23.7 13.8 26.1 29.9 51.8 34.5 24.9 27.7 53.3 37.2 50.2 15.6 11.1 22.5 15.2 49.3 32.8 14.6 25.3 28.6 38.1 22.6 27.5 9.8 13.2 19.1 72.5 24.1 14.6 37.1 100.8 26.2 60.2 34.0 31.7 23.5 11.7 26.2 45.2 16.8 20.8 13.5 11.7 48.8 15.2 21.1 26.1 26.5 27.0 20.4 11.6 23.4 20.2 26.5 41.0 26.7 18.4 15.8 22.2 26.1 18.7 30.9 13.6 36.2 31.6 28.4 34.5 15.1 21.4 16.9 15.7 9.0 12.2 15.8 13.6 10.0 12.4 13.8 13.3 8.2 12.5 11.5 22.3 16.9 13.7 4.9 14.6 14.8 21.5 22.5 21.7 25.1 22.5 22.1 21.7 22.0 22.0 21.9 23.2 23.6 9.3 22.4 12.6 10.7 8.8 9.1 10.3 10.0 9.6 11.0 14.2 10.8 5.5 20.0 11.5 18.4 8.4 13.0 11.3 16.4 21.5 15.1 19.0 8.9 8.2 8.5 16.8 5.0 14.0 14.9 23.2 10.9 8.2 10.3 5.7 8.4 23.2 28.9 14.2 8.4 17.3 15.8 14.2 8.8 7.5 18.3 7.5 10.5 8.8 10.3 10.7 11.9 7.2 13.6 22.5 15.5 12.7 15.8 6.8 14.5 17.7 22.9 12.4 7.8 6.6 9.5 9.3 7.4 9.8 10.6 10.7 37.2 7.2 6.0 7.8 9.8 RNF187 "RACO-1, RACO1" ENSG00000168159 "Ring finger protein 187" Q5TA31 1 228487382-228496188 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Theca cells: 217.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "eosinophil: 3.6" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "U-266/70: 189.0" "Low region specificity" "Detected in all" HPA030098 Approved Supported Nucleoplasm,Cytosol Yes No "Cluster 52: Eosinophils - Transcription" "Cluster 18: Non-specific - Mitochondria" "Cluster 29: U-266 - Adaptive immune response" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Cytosol" "HPA030098: AB_10602923" "unprognostic (4.84e-2)" "unprognostic (1.97e-1)" "prognostic unfavorable (2.83e-4)" "unprognostic (4.90e-3)" "unprognostic (1.13e-1)" "unprognostic (2.93e-2)" "unprognostic (3.46e-2)" "unprognostic (2.53e-1)" "unprognostic (1.36e-1)" "unprognostic (5.66e-3)" "unprognostic (1.37e-1)" "unprognostic (1.55e-1)" "unprognostic (2.92e-3)" "unprognostic (1.59e-1)" "unprognostic (9.76e-2)" "unprognostic (1.76e-1)" "unprognostic (2.32e-2)" 26.8 66.6 16.2 7.5 16.2 11.3 25.8 14.8 24.3 40.5 3.4 28.1 8.6 31.8 4.3 59.1 28.7 5.6 35.4 15.9 16.9 40.7 52.0 23.6 7.3 19.4 15.2 39.3 34.5 22.5 47.7 5.5 18.4 33.5 3.7 9.0 39.7 8.2 64.2 45.0 22.5 5.6 15.6 37.0 27.6 20.8 18.5 8.5 36.1 19.8 6.1 29.9 41.2 19.8 26.7 23.1 14.8 28.9 16.8 12.5 26.6 21.5 17.3 15.6 12.7 12.8 19.2 65.9 43.1 28.9 11.4 20.9 19.1 22.1 5.8 25.9 28.5 20.8 13.2 12.6 46.1 22.1 34.4 20.4 44.7 11.6 15.8 18.3 14.0 52.6 35.6 115.2 12.4 17.7 35.2 20.8 30.7 19.1 24.0 27.8 12.5 61.5 11.4 17.2 29.9 30.0 21.9 44.1 62.3 4.3 34.6 50.2 27.8 18.3 16.9 19.6 19.3 189.0 56.7 36.4 46.7 22.7 28.7 0.0 0.5 3.6 0.6 1.0 0.7 0.5 0.7 1.0 0.6 1.0 0.6 0.7 0.1 0.4 1.4 0.7 0.6 0.3 16.2 16.2 14.8 24.3 15.9 16.9 19.4 15.2 18.4 15.6 18.5 19.8 54.0 25.6 15.5 8.1 47.2 36.2 42.9 10.6 38.7 85.2 59.5 58.5 70.8 65.8 14.2 40.5 18.8 19.7 52.2 39.8 113.5 15.2 0.8 35.5 47.2 32.1 40.0 118.4 16.6 24.5 27.1 54.4 34.7 32.0 44.5 45.0 41.7 67.4 27.4 55.5 17.2 36.6 2.0 40.1 30.5 4.2 24.5 35.8 39.2 12.2 29.7 145.3 62.8 7.1 12.6 21.4 23.4 25.9 35.4 44.0 32.9 126.4 10.3 47.7 19.7 52.2 38.4 4.2 21.5 57.0 55.3 17.6 54.6 217.5 38.6 31.7 RNF19A "DKFZp566B1346, dorfin, RNF19" ENSG00000034677 "Ring finger protein 19A, RBR E3 ubiquitin protein ligase" Q9NV58 8 100257060-100336218 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Karpas-707: 178.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011455, HPA023652" Approved NA NA "Cluster 42: Non-specific - Transcription" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 2: Karpas-707 - Immune response" "Cluster 24: Non-specific - Transcription regulation" "CAB011455: AB_2180446, HPA023652: AB_1847836" "unprognostic (2.55e-1)" "unprognostic (1.13e-1)" "unprognostic (1.84e-1)" "unprognostic (7.09e-2)" "unprognostic (3.36e-1)" "unprognostic (2.12e-2)" "unprognostic (7.96e-2)" "unprognostic (8.92e-2)" "unprognostic (1.13e-1)" "unprognostic (5.97e-2)" "unprognostic (5.20e-2)" "unprognostic (2.99e-1)" "prognostic unfavorable (7.99e-5)" "unprognostic (8.44e-2)" "unprognostic (8.19e-2)" "unprognostic (2.02e-1)" "prognostic favorable (3.28e-5)" 32.0 18.8 29.1 32.7 28.7 57.4 28.6 22.7 25.5 52.0 17.6 25.9 24.0 41.3 16.4 21.6 30.5 43.1 25.0 25.3 48.3 30.0 49.3 34.7 55.4 40.2 36.0 27.4 25.9 16.1 15.2 26.9 33.0 22.0 26.5 27.2 22.3 18.7 28.0 31.8 37.9 32.6 37.3 31.5 27.4 53.0 36.1 34.3 18.8 31.0 43.8 35.9 27.3 40.7 26.7 16.9 14.8 16.9 27.7 23.1 18.7 23.4 22.5 22.0 19.9 9.0 17.3 15.7 41.6 24.7 10.2 18.9 11.6 17.4 29.6 65.3 9.4 26.1 86.8 13.5 22.8 5.3 15.6 23.3 26.1 17.5 33.1 26.9 34.3 17.3 14.8 178.6 21.8 13.5 24.6 9.0 5.4 18.2 15.5 9.8 10.0 30.7 60.2 41.7 11.4 24.6 24.5 14.9 23.3 30.6 13.1 20.5 33.9 25.3 19.9 18.7 14.3 85.5 59.3 10.4 16.2 17.4 15.4 26.3 8.6 8.1 16.3 6.8 10.4 15.5 13.4 12.6 5.7 13.9 6.9 9.8 19.6 6.2 14.2 14.1 14.7 5.8 29.1 28.7 22.7 25.5 25.3 48.3 40.2 36.0 33.0 37.3 36.1 40.7 70.8 51.3 51.6 106.7 101.7 40.1 83.4 56.9 18.8 29.9 44.7 32.5 40.6 110.1 83.6 44.1 60.5 11.0 184.8 61.6 7.9 65.0 183.8 165.9 78.2 66.3 20.8 124.8 76.9 40.2 14.5 62.5 67.8 242.1 43.0 172.0 32.2 42.9 23.0 58.9 69.7 25.9 42.7 30.5 41.8 259.4 58.4 39.2 21.4 73.1 24.1 43.5 65.9 35.7 39.9 49.0 32.0 68.8 161.7 66.3 50.9 54.1 106.2 48.4 19.7 77.4 46.3 77.8 47.2 26.1 60.4 8.2 204.6 46.3 21.8 144.9 RNF19B "FLJ90005, IBRDC3" ENSG00000116514 "Ring finger protein 19B" Q6ZMZ0 1 32936445-32964809 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Adaptive immunity, Immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 79.0" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 16.9" "Lineage enriched" "Detected in all" 8 "granulocytes: 16.9" "Cell line enhanced" "Detected in all" "Daudi: 107.6;Karpas-707: 124.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA049587, HPA063640" Approved Approved Cytosol NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 2: Karpas-707 - Immune response" "Cluster 41: Macrophages - Immune response" Cytosol "HPA049587: AB_2680826, HPA063640: " "unprognostic (2.83e-2)" "unprognostic (1.77e-2)" "unprognostic (1.86e-2)" "unprognostic (2.01e-1)" "unprognostic (1.78e-2)" "prognostic favorable (3.39e-4)" "prognostic unfavorable (5.41e-6)" "unprognostic (8.78e-2)" "unprognostic (5.02e-1)" "unprognostic (1.69e-1)" "unprognostic (9.85e-2)" "unprognostic (1.38e-1)" "prognostic favorable (4.39e-5)" "unprognostic (2.58e-2)" "unprognostic (4.93e-2)" "unprognostic (3.30e-1)" "unprognostic (1.23e-2)" 14.5 19.1 10.7 24.3 9.6 74.1 10.9 14.5 10.7 16.8 7.6 23.3 25.0 15.0 5.0 35.3 12.3 17.4 10.4 9.9 12.1 21.1 11.3 21.1 17.7 10.7 9.6 9.7 9.2 11.5 7.9 14.9 11.8 11.0 25.8 18.9 15.4 8.9 16.2 22.6 21.7 18.0 11.6 15.1 13.1 79.0 10.8 13.0 9.0 11.1 30.6 30.1 20.9 11.6 18.7 14.3 11.9 11.3 7.1 9.6 79.5 8.5 10.0 14.7 15.6 16.8 54.9 107.6 14.2 10.7 18.2 26.5 14.3 19.8 13.3 39.6 9.5 9.2 10.5 16.9 22.5 14.7 19.0 7.9 36.3 32.5 39.3 17.2 31.9 10.3 11.7 124.8 14.5 6.1 9.6 18.4 19.2 21.1 15.8 12.7 17.3 11.3 11.5 26.4 18.9 9.6 27.0 9.1 63.1 29.1 8.0 20.8 35.1 8.1 11.5 21.1 15.1 29.6 16.1 38.0 11.9 14.7 12.5 6.1 2.0 4.0 1.6 1.9 1.3 1.2 1.4 0.7 1.4 1.5 0.4 0.6 16.9 1.0 1.7 0.6 1.7 0.8 10.7 9.6 14.5 10.7 9.9 12.1 10.7 9.6 11.8 11.6 10.8 11.6 20.6 12.8 4.4 5.5 8.7 46.1 27.0 26.7 24.5 4.6 15.8 11.7 16.2 10.0 9.9 7.3 2.1 12.6 14.6 48.0 1.9 12.9 34.8 25.4 7.3 15.3 11.3 5.2 9.7 11.5 6.3 8.4 13.3 36.9 4.5 3.2 7.1 4.8 13.5 3.3 9.8 22.1 6.1 20.9 37.7 26.3 2.1 42.4 5.4 19.7 39.5 2.8 2.1 7.5 6.6 25.7 31.9 3.8 4.6 34.2 38.6 9.2 14.4 7.7 0.0 5.9 9.6 34.7 16.3 23.9 32.5 7.4 10.3 2.3 16.3 41.7 RNF2 "BAP-1, BAP1, DING, HIPI3, RING1B, RING2" ENSG00000121481 "Ring finger protein 2" Q99496 1 185045526-185102603 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Spermatogonia: 83.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026803 Uncertain Enhanced "Nucleoplasm,Nuclear bodies" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 28: Placenta - Pregnancy" "Cluster 5: NTERA-2 - Transcription" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" Nucleoplasm "Nuclear bodies" "HPA026803: AB_10602086" "unprognostic (1.23e-1)" "unprognostic (3.71e-2)" "unprognostic (1.70e-1)" "unprognostic (1.35e-3)" "unprognostic (1.70e-2)" "unprognostic (1.19e-1)" "prognostic unfavorable (1.08e-5)" "unprognostic (5.85e-2)" "unprognostic (3.56e-3)" "unprognostic (1.62e-2)" "unprognostic (2.01e-2)" "unprognostic (5.51e-2)" "prognostic unfavorable (1.94e-7)" "unprognostic (2.08e-1)" "unprognostic (5.51e-2)" "unprognostic (9.89e-3)" "unprognostic (2.52e-1)" 9.5 8.1 5.4 10.2 6.7 13.8 12.5 6.1 7.0 10.3 3.7 9.3 8.4 10.7 8.5 8.4 8.6 9.4 7.4 7.0 7.5 9.6 8.3 8.3 11.5 4.0 4.8 9.3 9.6 8.7 5.6 21.7 4.8 8.5 9.7 11.8 9.6 10.4 8.2 6.4 6.5 10.9 4.5 10.4 9.6 21.9 7.9 12.3 10.8 9.0 12.3 16.5 8.7 5.1 34.0 18.6 62.8 25.4 17.8 30.3 65.3 24.0 28.4 35.5 28.3 29.9 53.3 10.2 29.2 29.0 24.4 11.5 43.7 32.7 41.7 31.1 28.4 54.9 10.2 25.8 27.5 56.1 29.7 29.7 19.6 29.6 36.4 27.9 36.6 34.4 44.7 22.5 25.1 21.2 48.5 17.6 86.3 27.4 11.0 55.1 41.3 9.8 25.7 23.6 18.9 33.4 17.3 9.9 46.7 67.8 19.7 27.5 28.4 25.4 33.6 25.1 29.8 39.0 26.2 36.3 16.1 25.7 28.9 31.0 22.4 27.7 17.1 27.7 24.4 20.1 15.5 15.8 25.7 21.9 15.1 15.6 9.8 24.4 29.9 13.4 17.8 16.3 5.4 6.7 6.1 7.0 7.0 7.5 4.0 4.8 4.8 4.5 7.9 5.1 22.6 3.2 6.4 11.4 23.6 23.2 27.6 10.2 26.7 10.3 18.2 11.8 8.4 7.2 6.6 9.2 4.2 25.4 24.5 11.2 23.5 11.5 6.1 11.2 10.8 20.3 29.5 29.4 23.1 12.6 53.0 17.9 12.8 10.3 12.7 16.9 23.2 8.8 20.1 6.7 20.5 9.2 8.2 21.4 55.2 5.6 9.6 22.0 21.4 20.6 25.4 13.3 10.3 18.6 15.1 11.3 16.9 11.7 15.5 30.2 4.1 16.4 8.8 7.2 0.0 11.7 13.4 35.6 83.1 15.8 20.3 28.5 20.7 15.6 11.3 38.0 RNF20 "BRE1, BRE1A, FLJ11189, FLJ20382, hBRE1, KAIA2779" ENSG00000155827 "Ring finger protein 20" Q5VTR2 9 101533853-101563344 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Chromatin regulator, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 76.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB012478, HPA051773" Supported Enhanced Nucleoplasm NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm "CAB012478: , HPA051773: AB_2681604" "unprognostic (7.02e-2)" "unprognostic (2.21e-1)" "unprognostic (9.04e-2)" "unprognostic (2.03e-1)" "unprognostic (3.12e-2)" "unprognostic (1.68e-1)" "unprognostic (1.41e-2)" "unprognostic (2.90e-1)" "unprognostic (2.01e-1)" "unprognostic (5.47e-2)" "unprognostic (7.27e-3)" "unprognostic (1.60e-1)" "prognostic favorable (1.64e-6)" "unprognostic (2.72e-1)" "unprognostic (1.76e-1)" "unprognostic (2.32e-1)" "unprognostic (9.54e-3)" 17.8 17.8 21.3 16.3 24.6 14.8 19.0 22.0 22.8 17.0 21.4 17.7 11.1 19.0 19.2 21.6 19.8 14.1 26.4 20.4 23.2 21.4 15.7 16.3 18.6 22.8 23.7 21.5 21.3 28.1 10.3 14.6 23.7 20.9 16.9 30.4 16.7 17.9 29.7 17.3 12.3 18.9 22.0 17.6 14.5 32.5 22.6 19.9 23.4 24.9 21.0 15.0 15.0 26.8 25.8 64.2 36.4 40.0 43.8 34.4 31.0 44.1 35.3 43.1 37.6 39.2 26.8 56.8 23.2 34.3 36.0 64.0 42.6 37.5 44.1 59.7 19.8 30.5 55.9 39.7 32.2 53.0 35.2 34.0 39.4 38.2 49.2 32.4 25.7 20.7 29.5 32.5 47.4 33.6 41.4 14.0 80.5 57.8 32.3 39.4 125.7 28.3 17.8 24.5 38.7 48.6 62.1 32.9 36.1 36.3 29.7 24.7 36.6 39.8 39.7 28.6 37.3 35.1 118.0 30.4 35.1 19.6 49.2 24.5 15.2 23.7 20.4 20.3 15.5 15.3 16.7 15.4 14.6 12.4 17.3 16.4 15.7 17.1 30.0 9.2 14.7 13.4 21.3 24.6 22.0 22.8 20.4 23.2 22.8 23.7 23.7 22.0 22.6 26.8 15.9 25.6 31.2 10.7 16.8 6.4 9.7 13.7 17.1 32.4 11.6 11.4 49.5 8.6 23.9 22.0 6.2 16.7 10.2 17.9 5.9 18.3 54.5 20.3 18.5 18.7 24.6 22.3 16.3 13.8 11.5 16.9 10.2 11.5 22.1 19.7 11.7 18.1 16.4 43.7 18.7 12.1 16.2 27.4 4.3 21.4 18.0 20.0 10.6 8.4 31.4 31.4 33.0 11.1 21.9 11.0 13.0 23.7 13.1 9.3 10.1 11.5 28.5 26.5 32.9 21.8 17.5 76.0 16.7 18.3 5.8 7.7 16.1 15.4 15.3 6.4 RNF216 "TRIAD3, UBCE7IP1, ZIN" ENSG00000011275 "Ring finger protein 216" Q9NWF9 7 5620047-5781696 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Ubl conjugation pathway" Transferase "Disease variant, Hypogonadotropic hypogonadism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 145.5;Late spermatids: 257.6;Spermatocytes: 159.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018955, HPA021123" Supported Supported Nucleoplasm,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 43: Testis - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Cytosol Nucleoplasm "HPA018955: AB_1858500, HPA021123: AB_1858501" "unprognostic (3.31e-2)" "unprognostic (4.24e-2)" "unprognostic (1.28e-2)" "unprognostic (1.58e-2)" "unprognostic (1.81e-2)" "unprognostic (1.56e-1)" "prognostic unfavorable (2.26e-4)" "unprognostic (2.35e-1)" "unprognostic (2.40e-1)" "unprognostic (1.40e-2)" "prognostic favorable (6.24e-5)" "unprognostic (2.88e-2)" "unprognostic (9.01e-2)" "unprognostic (3.49e-1)" "unprognostic (1.73e-2)" "unprognostic (1.06e-2)" "unprognostic (3.69e-3)" 14.3 12.3 14.3 12.8 15.9 15.6 13.1 12.6 14.6 13.2 10.0 25.5 8.1 21.9 8.2 12.3 15.8 8.7 21.7 13.8 17.5 10.0 10.1 12.8 17.0 14.9 15.4 16.5 14.9 13.9 15.4 7.7 14.8 14.6 5.8 7.2 11.4 13.7 19.6 13.3 17.9 15.0 12.8 19.2 14.6 30.1 16.2 12.8 12.7 11.9 11.5 16.4 10.9 14.3 22.0 23.6 17.0 32.8 21.6 14.6 11.5 20.7 19.3 17.6 15.8 16.7 12.3 17.3 11.4 22.0 38.7 17.1 13.6 15.3 10.3 11.4 19.3 12.5 13.6 18.0 27.7 19.5 25.3 21.4 20.4 16.2 14.6 18.4 15.0 19.2 28.4 12.9 18.9 35.2 8.8 44.7 25.7 13.1 20.0 26.1 23.4 12.2 13.9 13.9 14.1 25.3 11.8 33.9 13.2 15.3 14.2 28.2 20.5 24.9 39.9 25.2 22.8 11.4 9.0 16.0 19.6 21.7 37.4 3.5 7.7 24.2 10.1 8.3 9.4 8.3 9.3 8.7 6.3 8.8 10.9 11.3 13.2 12.7 8.7 7.1 8.3 6.9 14.3 15.9 12.6 14.6 13.8 17.5 14.9 15.4 14.8 12.8 16.2 14.3 33.4 6.4 23.9 34.9 33.6 16.6 20.8 11.9 15.9 36.4 16.1 17.8 33.3 8.6 13.6 12.9 52.1 14.1 47.7 10.3 25.4 17.6 145.5 14.6 33.7 29.7 6.0 8.8 50.2 13.7 12.9 26.7 16.3 16.9 19.6 34.0 26.4 15.1 22.9 28.6 61.7 15.4 6.1 23.0 29.3 257.6 37.3 23.1 12.4 49.6 37.0 30.2 56.7 46.3 64.2 15.6 7.0 30.1 20.3 24.2 13.0 14.9 13.7 48.5 26.3 46.0 30.0 159.8 124.2 12.9 16.2 15.2 40.2 22.8 11.8 15.2 RNF217 "C6orf172, dJ84N20.1, IBRDC1, MGC26996" ENSG00000146373 "Ring finger protein 217" Q8TC41 6 124962545-125092633 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 42.7" "Cell type enhanced" "Detected in many" "Early spermatids: 127.8;Oligodendrocytes: 102.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029598 Uncertain NA NA "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 9: U-2 OS - Unknown function" "Cluster 23: Spermatids - Flagellum & Golgi organization" "HPA029598: AB_10602297" "unprognostic (2.96e-2)" "unprognostic (2.34e-3)" "unprognostic (8.07e-2)" "unprognostic (8.62e-2)" "unprognostic (1.94e-1)" "unprognostic (2.06e-2)" "unprognostic (1.06e-1)" "unprognostic (7.22e-3)" "unprognostic (4.94e-2)" "unprognostic (6.69e-2)" "unprognostic (2.47e-1)" "unprognostic (2.61e-1)" "prognostic unfavorable (4.60e-5)" "unprognostic (8.29e-4)" "unprognostic (2.16e-1)" "unprognostic (7.52e-2)" "prognostic unfavorable (1.92e-4)" 8.0 3.0 3.4 2.0 2.5 11.0 6.0 3.0 2.3 6.3 4.9 7.2 1.3 4.4 2.0 5.0 7.4 4.2 5.1 3.0 2.7 1.9 5.7 6.3 0.7 3.0 1.8 8.6 2.8 42.7 2.9 3.9 2.4 3.5 1.3 3.6 4.7 3.6 7.6 9.1 2.5 4.1 1.1 1.8 3.5 6.9 2.6 1.5 5.8 5.9 0.4 5.3 5.7 5.4 4.9 5.0 1.7 0.6 6.1 2.4 9.7 6.6 8.9 4.4 5.8 0.0 4.6 0.0 9.0 6.3 10.1 7.0 1.0 5.9 6.2 0.0 5.5 2.7 7.6 1.5 5.7 0.0 0.2 6.5 5.4 3.3 9.7 5.2 5.0 0.0 14.0 0.0 7.8 0.0 0.0 0.0 1.5 0.0 1.3 0.1 6.8 0.0 4.5 2.2 0.8 0.0 2.9 0.7 2.5 4.8 4.8 0.8 8.1 3.6 11.5 0.0 14.3 0.0 0.0 0.0 2.7 0.0 4.4 0.1 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 2.5 3.0 2.3 3.0 2.7 3.0 1.8 2.4 1.1 2.6 5.4 25.0 22.4 21.0 49.0 0.6 48.2 15.8 17.5 18.2 6.3 10.0 10.7 14.4 4.3 12.1 5.5 16.7 24.2 0.9 1.3 0.0 8.1 127.8 11.4 21.5 19.0 3.0 6.5 56.3 9.6 29.7 23.1 4.6 22.8 1.3 9.0 15.7 26.9 9.8 21.9 65.0 2.4 12.2 14.6 20.9 62.1 25.7 11.3 19.6 51.5 9.8 4.2 1.0 37.7 102.1 11.8 2.0 21.1 0.4 21.6 6.9 2.3 9.6 5.7 6.6 44.9 12.3 1.7 2.9 17.5 47.0 17.9 1.8 5.3 4.3 16.3 RNF25 "AO7, FLJ13906" ENSG00000163481 "Ring finger protein 25" Q96BH1 2 218663892-218672002 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036420, HPA036421" Uncertain Approved "Nucleoplasm,Actin filaments,Cytosol" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 80: Striated muscle - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 66: Spermatocytes - Spermatogenesis" Cytosol "Nucleoplasm, Actin filaments" "HPA036420: AB_2675114, HPA036421: AB_10669604" "unprognostic (3.22e-2)" "unprognostic (7.85e-3)" "unprognostic (1.34e-2)" "unprognostic (2.29e-2)" "unprognostic (1.33e-1)" "unprognostic (1.31e-1)" "prognostic unfavorable (6.58e-4)" "unprognostic (3.58e-2)" "unprognostic (2.67e-2)" "unprognostic (3.46e-1)" "unprognostic (2.04e-3)" "unprognostic (8.82e-2)" "unprognostic (1.26e-3)" "unprognostic (2.50e-1)" "unprognostic (1.37e-1)" "unprognostic (2.44e-1)" "unprognostic (6.69e-2)" 10.9 11.4 18.5 8.9 18.6 7.3 10.9 18.3 21.0 12.2 17.1 12.0 6.2 12.7 15.8 11.7 12.4 10.8 13.9 18.6 19.7 10.4 11.1 10.4 14.5 18.4 18.4 14.5 11.5 15.1 11.4 11.4 19.0 11.8 8.2 7.0 11.0 13.9 15.0 14.5 7.9 13.6 18.5 10.3 9.4 14.3 19.2 15.1 14.1 17.1 11.9 14.0 9.7 19.0 18.8 20.4 22.1 24.6 27.6 17.5 20.4 27.3 43.5 58.0 53.6 32.4 13.2 11.6 17.6 42.3 35.2 19.5 22.1 33.9 31.0 16.4 27.3 22.7 21.3 34.6 33.6 19.3 20.6 33.9 30.9 55.5 44.7 21.4 31.0 40.9 27.4 24.3 41.1 45.3 20.6 20.4 32.9 16.2 23.4 23.2 15.5 15.9 36.3 21.8 19.5 23.8 18.1 17.2 28.4 21.9 20.6 25.6 26.6 40.2 20.5 19.2 31.1 23.7 13.7 23.5 33.4 19.1 25.7 58.6 21.5 32.6 26.0 21.3 24.8 25.7 25.7 27.2 17.1 30.4 29.0 23.2 17.1 30.5 25.2 15.0 25.9 24.8 18.5 18.6 18.3 21.0 18.6 19.7 18.4 18.4 19.0 18.5 19.2 19.0 4.2 0.0 0.5 5.2 7.8 6.2 4.8 16.3 6.8 7.7 3.4 3.7 4.0 10.0 8.9 1.8 8.4 12.3 4.5 7.4 15.6 12.3 16.8 6.3 8.1 7.6 1.2 2.1 6.2 12.9 9.7 7.5 9.7 4.8 7.0 5.9 8.9 7.1 13.2 5.0 5.8 5.5 8.2 5.0 4.0 5.3 7.2 5.5 8.8 2.8 8.9 7.9 9.2 3.5 4.9 12.7 9.6 12.8 8.5 3.8 7.2 14.8 8.2 5.0 26.3 5.6 9.2 19.3 12.8 5.9 6.8 10.0 8.0 8.5 6.1 3.6 RNF31 "FLJ10111, FLJ23501, HOIP, Paul, ZIBRA" ENSG00000092098 "Ring finger protein 31" Q96EP0 14 24146683-24160660 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 16.0;Excitatory neurons: 8.8;Gastric mucus-secreting cells: 7.7;Inhibitory neurons: 8.2;Microglial cells: 10.3;Oligodendrocyte precursor cells: 9.5;Plasma cells: 8.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "CAB009063, HPA048745" Approved Approved Cytosol NA NA "Cluster 15: NK-cells - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 59: Non-specific - Transcription" Cytosol "CAB009063: AB_2127706, HPA048745: AB_2680509" "unprognostic (3.58e-2)" "unprognostic (5.22e-2)" "unprognostic (2.51e-2)" "unprognostic (9.05e-2)" "unprognostic (2.52e-1)" "unprognostic (6.24e-2)" "unprognostic (9.09e-3)" "unprognostic (1.55e-2)" "unprognostic (3.11e-3)" "unprognostic (1.96e-2)" "unprognostic (1.33e-1)" "unprognostic (2.46e-1)" "unprognostic (6.21e-3)" "unprognostic (1.15e-1)" "unprognostic (2.59e-1)" "unprognostic (1.41e-2)" "unprognostic (1.99e-1)" 14.3 18.5 4.9 9.1 4.8 9.5 14.3 4.2 6.6 16.7 3.6 15.0 7.1 18.2 6.9 16.2 14.8 6.9 19.6 4.6 4.1 17.5 15.8 14.9 10.4 5.3 4.4 17.8 23.9 10.4 18.7 6.9 4.5 16.6 6.6 4.1 16.9 7.1 41.5 19.3 15.9 9.6 4.5 26.1 17.9 16.4 4.8 11.7 16.5 17.9 9.6 15.1 14.0 4.4 6.1 10.8 10.5 14.8 6.1 6.3 23.2 9.9 15.1 18.2 15.6 10.2 13.5 10.9 6.9 11.8 10.2 7.6 5.4 11.8 9.7 13.2 4.2 11.0 9.5 32.5 12.8 17.5 18.8 12.3 10.4 7.2 12.9 9.6 12.0 7.9 5.9 12.9 7.7 17.3 17.6 8.6 5.3 9.9 12.7 10.1 9.8 6.8 8.9 20.8 9.9 12.7 8.6 25.6 12.5 9.2 7.4 13.3 11.1 12.6 10.2 8.8 8.9 21.4 21.2 11.5 4.4 6.1 13.6 0.0 0.8 0.8 0.6 1.7 1.8 0.4 0.9 0.6 0.5 0.4 0.6 0.4 1.7 1.7 1.0 1.8 1.1 0.4 4.9 4.8 4.2 6.6 4.6 4.1 5.3 4.4 4.5 4.5 4.8 4.4 0.9 0.0 4.6 16.0 5.2 0.6 0.3 0.0 4.6 0.6 1.0 0.3 0.3 0.0 3.1 0.0 0.0 0.6 1.0 0.8 0.0 0.3 0.1 1.0 1.3 1.3 0.0 3.8 8.8 0.0 0.5 1.3 7.7 0.9 0.0 1.1 0.4 0.8 0.4 0.0 8.2 0.3 2.0 0.6 1.5 0.4 0.3 2.7 0.0 10.3 0.5 0.3 3.1 9.5 7.3 0.2 0.2 0.0 8.7 0.2 0.5 0.2 0.8 0.8 0.0 1.4 1.2 1.6 0.8 5.7 0.9 0.5 4.3 0.8 0.1 0.3 RNF40 "BRE1B, KIAA0661, RBP95, STARING" ENSG00000103549 "Ring finger protein 40" O75150 16 30761745-30776307 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Chromatin regulator, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal tubular cells: 88.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041330, HPA054227" Approved Supported Nucleoplasm NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 14: REH - Unknown function" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm "HPA041330: AB_10793872, HPA054227: AB_2682422" "unprognostic (1.61e-1)" "unprognostic (1.74e-2)" "unprognostic (3.06e-1)" "unprognostic (4.87e-2)" "unprognostic (1.21e-1)" "unprognostic (4.01e-1)" "unprognostic (5.97e-3)" "unprognostic (1.56e-1)" "unprognostic (1.50e-1)" "unprognostic (1.89e-1)" "unprognostic (2.16e-2)" "unprognostic (1.91e-2)" "prognostic favorable (8.11e-8)" "unprognostic (9.96e-2)" "unprognostic (1.36e-1)" "unprognostic (6.55e-3)" "unprognostic (6.60e-3)" 24.4 28.7 23.4 26.7 25.9 55.3 21.5 25.5 24.8 26.7 26.2 26.0 24.9 29.3 15.5 31.8 25.4 26.0 16.3 25.8 22.4 19.9 20.9 22.5 26.9 25.9 24.3 35.2 29.8 35.2 21.7 21.4 23.0 22.6 17.6 18.1 33.7 22.5 17.5 27.4 24.7 21.5 22.3 24.7 23.4 38.0 26.1 24.6 29.0 16.0 22.3 21.4 22.7 28.8 58.5 87.9 53.0 52.7 41.9 43.3 58.6 58.7 47.4 66.8 52.4 72.4 53.7 46.5 82.9 50.5 45.5 62.1 99.2 55.5 53.0 66.7 120.9 45.2 99.9 77.2 53.3 79.8 54.0 41.3 43.5 83.3 48.8 44.2 57.7 40.6 101.3 46.1 42.5 98.3 76.4 74.4 55.6 47.7 55.4 149.9 58.8 91.6 29.8 52.0 89.9 65.0 45.0 58.7 41.8 27.9 88.9 88.5 60.8 74.6 37.4 53.8 67.7 66.1 87.2 93.0 62.3 70.6 77.1 6.5 13.6 17.1 13.1 14.1 13.1 8.1 7.1 10.0 13.9 5.9 5.3 8.8 16.1 11.1 17.1 6.6 6.7 16.2 23.4 25.9 25.5 24.8 25.8 22.4 25.9 24.3 23.0 22.3 26.1 28.8 13.5 12.8 24.9 18.3 17.2 13.9 12.3 10.2 16.5 12.8 18.9 15.6 3.2 28.6 11.5 22.0 4.2 16.0 20.7 27.7 88.0 15.2 23.7 24.7 20.8 14.9 13.9 37.4 10.3 13.3 16.9 14.5 26.0 29.2 4.5 19.3 10.8 22.9 21.5 5.0 11.2 23.2 10.2 23.0 12.6 22.0 18.0 16.9 17.8 4.7 16.7 16.5 11.3 13.0 8.7 16.3 15.4 17.7 21.8 15.8 24.2 26.5 12.4 13.7 13.1 15.8 13.3 27.1 11.3 20.6 19.7 22.7 16.0 22.2 25.8 11.2 RNF41 "NRDP1, SBBI03" ENSG00000181852 "Ring finger protein 41" Q9H4P4 12 56202179-56221933 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Autophagy, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 92.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016812 Approved Approved "Nucleoplasm,Nuclear bodies,Midbody ring" Yes NA "Cluster 2: Granulocytes - Unknown function" "Cluster 38: Heart - Muscle contraction" "Cluster 30: Epithelial cell lines - Translation" "Cluster 57: B-cells - Immune response" "Nucleoplasm, Nuclear bodies" "Midbody ring" "HPA016812: AB_1856370" "unprognostic (1.14e-2)" "unprognostic (6.30e-2)" "unprognostic (4.04e-2)" "unprognostic (6.86e-2)" "unprognostic (9.59e-2)" "unprognostic (8.22e-2)" "prognostic unfavorable (6.49e-4)" "unprognostic (6.93e-2)" "unprognostic (4.18e-2)" "unprognostic (1.67e-1)" "unprognostic (5.80e-2)" "unprognostic (5.90e-2)" "prognostic favorable (2.52e-5)" "unprognostic (1.64e-1)" "unprognostic (1.65e-1)" "unprognostic (1.45e-1)" "unprognostic (1.43e-1)" 32.2 24.6 22.5 18.0 23.3 19.6 21.4 15.7 23.8 21.2 13.0 23.8 12.4 22.3 13.2 23.1 24.3 25.5 32.7 24.6 24.8 19.7 15.1 23.8 23.4 16.8 19.1 22.9 23.0 27.4 22.8 21.3 21.2 33.9 19.0 23.8 15.0 20.7 34.0 15.0 16.1 28.5 15.3 20.6 17.0 15.9 23.5 26.5 28.6 40.8 25.1 28.2 17.0 19.2 21.6 32.6 34.7 55.2 71.0 51.3 25.8 70.8 69.5 62.2 50.2 40.0 27.6 41.6 36.7 60.2 20.6 24.3 47.4 34.1 44.9 43.8 25.7 55.8 22.3 23.2 148.3 61.6 58.3 66.0 78.6 52.0 91.0 81.7 61.3 34.5 40.4 41.3 35.1 34.9 35.6 27.6 41.9 21.6 37.8 38.2 24.9 25.3 33.3 31.3 62.9 38.1 61.9 35.0 55.4 34.3 49.2 71.3 37.3 31.3 32.9 40.6 27.8 29.6 36.6 37.5 37.2 36.4 38.0 59.1 27.2 99.9 27.6 26.7 24.9 50.3 23.0 24.3 30.6 55.1 23.4 24.0 36.2 33.1 28.3 23.7 29.4 31.0 22.5 23.3 15.7 23.8 24.6 24.8 16.8 19.1 21.2 15.3 23.5 19.2 18.9 44.8 22.6 11.1 42.2 12.0 19.9 8.6 19.9 30.7 22.2 21.1 24.6 24.3 18.8 16.5 22.9 15.2 17.0 10.2 17.6 15.3 92.8 13.9 14.2 20.7 20.4 11.1 15.0 21.3 18.5 22.7 9.7 14.2 25.9 16.8 30.0 16.7 19.3 28.6 15.7 13.9 8.2 34.9 22.7 58.0 23.0 25.0 7.2 9.4 33.5 26.2 15.5 14.6 12.3 20.8 20.3 25.9 14.6 33.5 12.3 19.6 18.0 18.3 26.3 23.2 27.4 10.4 14.2 14.4 16.6 16.8 16.6 17.1 14.3 23.1 RNF5 "G16, NG2, RING5, RMA1" ENSG00000204308 "Ring finger protein 5" Q99942 6 32178405-32180793 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Proximal tubular cells: 371.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034107, HPA065032" Uncertain Supported "Endoplasmic reticulum" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 43: THP-1 - Innate immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Endoplasmic reticulum" "CAB034107: AB_2238618, HPA065032: AB_2685408" "unprognostic (1.94e-1)" "unprognostic (1.31e-1)" "unprognostic (1.49e-1)" "unprognostic (4.45e-3)" "unprognostic (1.35e-2)" "unprognostic (1.23e-1)" "unprognostic (1.36e-1)" "unprognostic (1.37e-2)" "unprognostic (4.07e-1)" "prognostic favorable (2.44e-4)" "unprognostic (1.95e-1)" "unprognostic (8.93e-3)" "unprognostic (2.91e-3)" "unprognostic (8.84e-2)" "unprognostic (9.17e-2)" "unprognostic (2.72e-1)" "unprognostic (2.99e-2)" 38.2 75.9 60.4 29.2 63.4 40.4 44.5 64.6 66.0 44.9 59.4 59.5 61.6 44.8 45.8 37.5 54.1 46.1 81.7 59.2 60.6 115.6 126.2 38.7 43.1 65.0 60.6 60.4 41.6 55.5 17.2 30.1 62.6 44.0 62.4 42.9 43.9 31.7 89.6 44.6 76.5 30.5 62.8 38.8 55.3 29.5 61.8 60.7 48.6 76.5 43.4 45.1 38.8 67.0 51.2 66.1 43.7 167.5 46.9 31.3 34.0 20.6 26.5 44.4 48.7 89.1 42.1 65.2 70.8 47.9 62.5 41.7 80.3 45.1 45.2 41.8 107.5 53.9 69.5 184.4 55.0 0.2 101.2 32.3 60.3 73.3 53.6 77.2 89.1 115.0 136.6 67.8 63.8 71.9 66.5 151.5 0.3 71.8 28.7 44.4 48.2 88.2 124.0 32.6 44.8 92.1 39.9 42.4 46.7 39.9 87.0 183.0 40.3 48.1 44.7 0.5 79.1 38.6 63.5 79.3 33.2 116.4 29.6 64.8 45.7 75.8 64.8 65.9 55.6 64.6 52.5 57.6 64.7 56.2 57.5 58.3 22.1 79.6 46.7 264.6 58.2 75.0 60.4 63.4 64.6 66.0 59.2 60.6 65.0 60.6 62.6 62.8 61.8 67.0 38.3 19.2 41.1 2.9 52.7 95.7 70.0 146.6 52.3 23.6 61.8 56.5 62.9 87.2 79.5 92.0 0.0 78.1 70.3 151.9 283.7 110.8 21.6 47.2 31.7 50.9 73.2 126.3 3.4 91.3 101.7 44.6 28.5 31.7 56.3 41.5 47.8 131.5 68.9 33.7 3.5 83.0 132.2 51.1 171.7 22.6 59.4 43.3 85.4 1.0 69.5 91.3 65.9 1.5 10.0 78.5 173.0 72.6 45.5 58.4 270.6 371.6 73.4 27.6 65.7 50.6 63.0 55.7 37.7 44.4 84.4 84.1 53.8 42.8 100.3 56.5 RNF8 KIAA0646 ENSG00000112130 "Ring finger protein 8" O76064 6 37353979-37394734 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, DNA damage, DNA repair, Host-virus interaction, Mitosis, Ubl conjugation pathway" "Chromatin regulator, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 76.0" "Not detected" "Not detected" "HPA050731, HPA064925" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 51: Myeloid cells - Hemostasis" Nucleoplasm Cytosol "HPA050731: AB_2681222, HPA064925: AB_2685385" "unprognostic (1.80e-2)" "unprognostic (2.23e-1)" "unprognostic (1.39e-2)" "unprognostic (8.20e-2)" "unprognostic (5.17e-2)" "unprognostic (3.99e-2)" "prognostic unfavorable (3.33e-5)" "unprognostic (2.36e-2)" "prognostic unfavorable (1.91e-4)" "unprognostic (2.26e-3)" "unprognostic (3.38e-1)" "prognostic unfavorable (4.99e-5)" "unprognostic (7.95e-3)" "unprognostic (1.78e-1)" "unprognostic (3.41e-2)" "unprognostic (3.66e-3)" "unprognostic (1.09e-1)" 5.0 7.8 10.0 3.5 10.1 4.6 5.2 11.8 14.3 7.7 9.3 6.3 3.1 7.0 2.1 10.6 6.0 4.0 8.6 10.1 10.5 8.8 4.8 5.9 4.2 10.2 10.6 7.6 4.5 7.4 6.6 4.8 10.3 6.0 3.6 9.0 6.2 5.2 8.1 7.6 5.0 4.9 9.4 4.7 5.2 11.2 11.2 5.8 4.5 10.6 6.6 6.5 7.8 9.9 12.5 7.3 17.3 20.7 13.7 19.6 4.9 12.6 15.5 23.4 25.6 11.0 6.8 15.3 7.5 12.4 20.1 11.4 24.4 16.0 24.4 16.2 23.7 26.5 12.0 16.6 7.8 14.3 18.7 9.8 15.2 14.0 16.2 14.3 22.9 17.9 18.1 5.2 13.6 8.3 17.4 17.5 12.1 6.3 9.4 13.5 16.0 10.6 12.1 8.7 34.0 11.4 9.5 10.6 18.0 11.3 9.5 13.6 10.4 15.4 13.5 14.7 18.8 15.2 21.8 76.0 7.5 20.1 18.0 1.0 4.3 2.5 9.5 5.8 8.8 8.1 7.0 9.2 7.8 4.9 6.1 8.1 0.5 7.9 8.8 3.3 9.1 5.2 10.0 10.1 11.8 14.3 10.1 10.5 10.2 10.6 10.3 9.4 11.2 9.9 21.0 19.2 25.9 13.4 15.0 18.2 22.2 26.0 26.2 26.7 16.5 20.4 31.1 12.8 18.5 25.8 39.6 24.8 18.2 10.3 15.6 24.7 41.1 68.5 32.2 19.2 22.2 18.7 17.0 18.9 25.8 28.0 16.3 52.3 28.5 37.0 27.8 16.5 17.5 50.5 15.9 16.5 14.2 13.9 17.7 30.2 26.8 24.0 10.6 11.2 19.6 25.4 37.0 12.5 20.5 28.8 18.1 30.9 13.7 31.8 11.8 20.6 23.8 32.3 13.1 23.2 20.8 46.5 34.5 34.2 22.0 5.9 19.3 22.0 18.0 21.9 RNGTT "hCAP, HCE, HCE1" ENSG00000111880 "RNA guanylyltransferase and 5'-phosphatase" O60942 6 88609897-88963618 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, mRNA capping, mRNA processing" "Hydrolase, Multifunctional enzyme, Nucleotidyltransferase, Protein phosphatase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 108.6;Inhibitory neurons: 110.2;Oligodendrocyte precursor cells: 96.5;Oligodendrocytes: 94.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003750 Approved Approved Nucleoplasm NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 34: Non-specific - Transcription" "Cluster 1: K-562 - Erythropoiesis" "Cluster 57: B-cells - Immune response" Nucleoplasm "HPA003750: AB_1856383" "unprognostic (5.19e-3)" "unprognostic (1.00e-1)" "unprognostic (2.82e-2)" "unprognostic (3.45e-3)" "unprognostic (4.82e-2)" "unprognostic (1.10e-1)" "prognostic unfavorable (1.37e-4)" "unprognostic (4.48e-3)" "unprognostic (1.28e-1)" "unprognostic (4.05e-3)" "unprognostic (3.76e-2)" "unprognostic (1.55e-1)" "unprognostic (2.23e-3)" "unprognostic (9.83e-2)" "unprognostic (6.55e-2)" "unprognostic (1.67e-1)" "unprognostic (8.08e-3)" 5.3 6.7 4.9 8.2 4.9 9.5 5.6 9.1 5.7 5.2 2.6 4.6 4.2 5.2 3.6 7.2 4.1 3.7 5.3 5.1 7.0 5.3 6.9 4.4 17.2 4.6 5.2 4.8 2.9 6.4 4.9 5.0 5.1 5.3 5.4 10.6 3.5 4.9 5.2 4.4 5.2 6.1 4.6 7.6 4.2 9.3 7.3 14.7 5.6 6.4 17.3 6.2 4.8 5.3 9.2 14.0 21.1 26.2 12.0 12.6 12.4 20.2 13.4 16.4 20.4 15.9 6.8 23.1 16.2 14.9 21.5 11.1 24.7 16.5 29.7 31.8 19.0 30.5 11.4 12.2 9.5 33.2 16.6 7.7 13.8 16.8 15.9 13.6 14.7 12.7 30.9 18.1 23.8 12.0 14.6 22.8 12.5 15.0 11.7 28.6 32.0 13.3 14.0 14.2 12.3 17.3 16.8 9.8 11.1 19.7 10.8 31.8 11.5 13.0 12.0 14.7 27.9 16.1 31.6 13.2 18.9 23.8 24.1 5.2 4.1 7.6 7.8 5.9 7.8 22.9 8.6 9.7 5.8 22.8 9.7 10.1 3.4 10.9 5.5 4.0 9.0 5.4 4.9 4.9 9.1 5.7 5.1 7.0 4.6 5.2 5.1 4.6 7.3 5.3 8.9 0.0 16.2 54.5 60.4 8.3 10.7 6.0 10.8 22.4 6.5 6.1 10.7 7.2 12.9 12.9 39.6 10.4 19.7 8.0 0.0 6.3 17.9 7.9 12.1 7.0 9.1 7.6 108.6 4.9 9.9 9.7 15.8 12.4 8.8 11.0 7.5 10.3 7.8 15.2 110.2 7.0 4.1 9.1 7.3 5.2 5.9 13.6 3.6 69.3 9.8 7.2 18.6 96.5 94.3 7.2 5.1 7.9 42.3 8.6 4.6 6.3 10.1 43.4 6.6 15.8 9.5 23.3 20.1 10.7 8.7 11.8 24.6 8.0 6.7 7.4 RNMT RG7MT1 ENSG00000101654 "RNA guanine-7 methyltransferase" O43148 18 13726660-13764556 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "mRNA capping, mRNA processing" "Methyltransferase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039409 Approved Supported "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" Nucleoplasm "Nucleoli fibrillar center" "HPA039409: AB_10795289" "unprognostic (3.02e-1)" "unprognostic (1.07e-2)" "unprognostic (3.48e-1)" "unprognostic (1.71e-3)" "unprognostic (3.57e-1)" "unprognostic (3.04e-1)" "unprognostic (6.17e-3)" "unprognostic (1.43e-1)" "unprognostic (3.76e-2)" "unprognostic (1.42e-3)" "unprognostic (9.45e-2)" "unprognostic (9.15e-2)" "unprognostic (1.00e-1)" "unprognostic (1.25e-1)" "unprognostic (1.56e-1)" "unprognostic (2.77e-2)" "unprognostic (1.78e-1)" 10.9 9.6 11.8 12.6 12.1 43.3 15.3 12.2 13.0 11.3 17.2 11.6 8.5 14.0 11.5 11.3 11.2 9.0 20.3 12.1 14.2 11.6 11.2 9.5 14.4 13.6 15.2 17.2 12.1 13.0 13.9 15.2 14.8 11.6 10.4 27.4 12.1 10.5 18.4 14.2 10.5 12.5 10.9 12.1 10.6 16.7 11.7 14.9 17.5 15.6 15.2 11.4 10.7 12.6 24.9 14.4 27.4 20.9 20.0 25.1 19.2 19.9 24.7 20.3 27.4 17.3 11.7 27.7 23.9 20.6 31.6 9.8 32.7 28.6 34.0 15.4 17.6 21.0 14.8 16.4 21.9 54.9 17.1 19.4 30.5 21.4 59.9 26.6 15.9 31.1 31.8 26.9 23.3 15.4 35.2 19.7 21.0 50.1 11.2 22.7 29.0 37.9 18.6 19.2 21.1 31.7 22.5 16.4 38.1 27.8 14.3 22.6 16.5 40.6 56.8 33.3 21.5 53.8 63.6 56.9 29.9 20.8 20.6 45.1 17.6 12.8 16.7 14.6 13.6 23.9 15.8 14.2 11.8 25.7 20.5 16.2 9.8 14.1 17.3 29.5 19.0 5.6 11.8 12.1 12.2 13.0 12.1 14.2 13.6 15.2 14.8 10.9 11.7 12.6 62.5 73.7 29.9 48.6 148.5 70.4 67.3 97.9 75.1 115.6 50.7 56.1 56.5 35.8 56.5 46.0 123.0 66.3 143.4 46.5 68.4 51.0 75.4 85.2 88.3 43.7 74.8 37.4 75.3 48.0 59.2 71.6 66.3 113.9 34.9 85.6 40.7 38.5 39.8 106.0 83.9 56.3 85.5 59.4 63.6 21.1 72.7 78.8 49.8 45.0 68.0 51.0 60.8 56.8 78.9 56.1 47.0 60.9 99.7 72.3 49.0 64.8 48.0 148.3 39.5 85.6 60.0 111.4 115.1 50.7 68.3 126.4 113.1 48.8 50.0 50.3 ROCK1 p160ROCK ENSG00000067900 "Rho associated coiled-coil containing protein kinase 1" Q13464 18 20946906-21111813 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 406.2;Late spermatids: 505.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004562, HPA007567, HPA045639" Approved NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 32: U-937 - Innate immune response" "Cluster 10: Non-specific - Unknown function" "CAB004562: AB_628223, HPA007567: AB_1856393, HPA045639: AB_2679401" "unprognostic (7.86e-2)" "unprognostic (2.86e-2)" "unprognostic (1.22e-1)" "unprognostic (6.63e-2)" "unprognostic (9.90e-2)" "unprognostic (1.17e-1)" "unprognostic (6.74e-2)" "unprognostic (1.00e-1)" "unprognostic (1.63e-1)" "unprognostic (8.89e-3)" "prognostic unfavorable (9.93e-4)" "unprognostic (3.85e-2)" "unprognostic (8.93e-3)" "unprognostic (3.04e-2)" "unprognostic (5.47e-2)" "unprognostic (3.19e-1)" "unprognostic (1.28e-1)" 8.0 4.2 3.8 5.7 4.8 18.2 6.0 4.4 3.9 5.3 4.6 5.0 3.6 5.9 4.6 4.2 6.3 4.2 5.5 2.8 3.5 4.4 4.8 7.6 5.5 5.4 4.0 5.4 5.1 2.9 2.9 4.4 4.9 4.4 3.2 4.8 4.4 3.4 2.6 3.7 5.2 3.2 4.4 6.2 5.8 2.6 4.5 5.5 4.5 1.9 4.2 6.6 5.4 5.3 6.5 3.9 3.9 3.8 7.2 7.7 6.3 8.9 4.3 3.9 4.2 6.6 2.7 8.0 6.2 10.5 2.1 5.2 3.6 5.2 7.8 11.4 4.1 6.4 7.3 2.9 3.6 17.9 9.6 5.6 4.6 5.8 4.7 3.2 6.0 3.1 3.7 7.9 4.6 4.1 8.5 3.8 3.2 4.3 6.6 11.9 4.5 3.1 3.7 5.9 4.5 3.5 7.1 4.6 3.6 3.4 4.6 6.7 9.9 7.7 6.4 7.1 7.2 10.7 5.3 9.0 5.8 7.5 4.8 3.0 5.0 6.8 5.0 3.2 4.0 3.9 3.6 3.8 4.2 5.0 3.5 3.5 18.0 2.8 4.0 5.5 3.6 2.5 3.8 4.8 4.4 3.9 2.8 3.5 5.4 4.0 4.9 4.4 4.5 5.3 98.2 96.1 88.7 64.6 112.6 46.3 60.4 30.7 43.9 100.4 32.2 35.6 138.6 28.6 61.4 33.1 131.3 57.5 136.9 36.6 15.6 62.5 406.2 64.8 86.9 94.4 99.0 47.9 81.3 38.0 64.9 78.4 62.7 73.8 72.7 68.5 60.0 47.4 60.3 60.6 74.2 45.8 40.7 135.3 126.7 505.0 97.6 166.2 65.8 106.8 137.1 52.3 204.9 87.0 140.0 70.9 62.8 138.8 83.2 63.2 32.3 21.0 44.6 128.6 170.9 81.4 197.6 107.4 80.9 38.7 36.7 43.0 127.4 70.5 38.9 73.3 ROCK2 ENSG00000134318 "Rho associated coiled-coil containing protein kinase 2" O75116 2 11179759-11348330 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Biological rhythms" "Kinase, Serine/threonine-protein kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Excitatory neurons: 280.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007459, CAB008666, HPA044109" Approved Supported Cytosol NA NA 710000 "Cluster 15: NK-cells - Transcription" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 48: Smooth muscle cells - ECM organization" Cytosol "CAB008666: AB_1622617, HPA007459: AB_1079828, HPA044109: AB_2678813" "unprognostic (4.55e-2)" "unprognostic (1.05e-2)" "unprognostic (4.18e-3)" "unprognostic (4.87e-2)" "unprognostic (1.49e-1)" "unprognostic (2.71e-1)" "unprognostic (1.39e-2)" "unprognostic (2.72e-1)" "unprognostic (3.62e-2)" "unprognostic (6.66e-2)" "unprognostic (3.83e-2)" "unprognostic (1.48e-1)" "prognostic unfavorable (1.57e-5)" "unprognostic (1.51e-1)" "unprognostic (1.99e-1)" "unprognostic (2.52e-2)" "unprognostic (3.47e-2)" 36.4 9.3 6.7 13.5 16.3 6.8 22.3 19.1 14.3 18.7 0.8 22.6 16.7 22.0 10.3 16.2 13.6 15.6 17.0 12.1 3.5 14.5 16.5 16.9 10.1 1.7 4.4 19.0 11.7 12.8 5.9 24.9 1.4 17.4 26.2 13.5 14.6 18.1 30.4 8.5 19.2 27.9 2.0 16.4 14.1 7.8 6.4 8.4 13.9 28.9 8.8 21.1 11.0 10.4 17.5 41.7 33.8 33.2 59.7 41.6 21.6 40.4 37.7 25.8 27.1 39.8 37.2 21.9 23.4 64.5 31.3 18.9 24.7 23.4 40.6 31.2 14.7 43.8 70.6 79.7 21.4 24.7 12.1 32.6 14.6 31.9 22.6 21.0 42.0 11.9 38.6 8.6 38.8 14.8 18.2 12.7 18.8 36.9 25.3 21.7 74.2 7.0 14.0 48.8 15.9 16.9 79.6 27.4 27.4 25.5 11.3 13.6 57.3 52.9 38.2 21.2 36.0 6.8 8.9 18.8 22.8 28.2 75.4 0.9 0.4 0.4 0.6 0.4 0.7 0.3 0.4 0.4 0.3 0.5 0.4 0.4 0.6 0.8 0.4 0.6 0.4 0.2 6.7 16.3 19.1 14.3 12.1 3.5 1.7 4.4 1.4 2.0 6.4 10.4 114.5 115.4 79.1 81.3 16.0 39.9 43.0 15.3 21.1 35.7 33.5 41.1 107.0 37.1 53.1 22.0 58.4 26.3 20.4 97.7 1.9 27.1 11.0 53.6 141.2 90.3 21.2 22.5 280.4 39.5 19.1 64.0 18.3 55.3 29.0 36.9 56.0 43.1 19.6 80.8 158.1 92.2 10.2 20.3 27.0 4.9 43.8 30.4 23.2 107.7 20.6 38.4 15.5 99.0 66.9 39.1 43.6 78.6 16.2 53.5 45.3 15.7 32.7 48.5 131.5 70.0 118.5 30.3 24.6 19.9 27.8 31.5 18.5 34.2 54.8 40.7 RORA "NR1F1, ROR1, ROR2, ROR3, RZRA" ENSG00000069667 "RAR related orphan receptor A" P35398 15 60488284-61229302 "Disease related genes, Human disease related genes, Metabolic proteins, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Biological rhythms, Transcription, Transcription regulation" "Activator, Developmental protein, DNA-binding, Receptor" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skin 1: 82.8" "Cell type enhanced" "Detected in many" "Astrocytes: 2125.3;Excitatory neurons: 627.1;Inhibitory neurons: 1056.8;Microglial cells: 757.0;Oligodendrocyte precursor cells: 1524.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Lineage enriched" "Detected in many" 4 "T-cells: 26.7" "Cell line enhanced" "Detected in many" "Karpas-707: 73.2;U-266/70: 41.7;U-266/84: 62.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009861, HPA074448" Approved Supported Nucleoli NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 64: Astrocytes - Nervous system maintenance" Nucleoli "CAB009861: AB_2180141, HPA074448: " "unprognostic (1.57e-1)" "unprognostic (4.76e-2)" "unprognostic (2.22e-1)" "unprognostic (2.92e-2)" "unprognostic (1.79e-2)" "unprognostic (1.00e-1)" "unprognostic (2.91e-3)" "unprognostic (4.08e-3)" "unprognostic (2.02e-2)" "unprognostic (1.13e-1)" "unprognostic (9.93e-2)" "unprognostic (1.34e-1)" "prognostic favorable (5.42e-6)" "unprognostic (6.94e-2)" "unprognostic (1.35e-1)" "unprognostic (2.55e-1)" "unprognostic (4.62e-2)" 8.2 38.0 19.9 6.2 11.7 17.5 13.6 51.1 13.1 10.5 10.2 6.9 2.6 6.0 4.7 17.3 6.8 9.1 7.2 3.7 12.6 12.6 28.7 11.2 6.2 7.8 36.0 9.9 14.0 10.1 7.6 2.9 5.9 5.7 3.5 37.8 8.5 5.5 41.4 82.8 6.3 5.4 4.5 9.3 6.2 13.9 49.6 4.3 12.8 20.3 7.5 5.2 9.2 4.2 0.1 0.8 2.7 0.0 3.4 1.7 0.9 1.3 1.5 1.2 1.4 1.8 0.5 0.0 0.6 3.4 3.6 0.5 6.1 2.6 2.2 2.9 5.2 0.0 0.4 2.9 1.3 0.0 0.3 7.8 0.6 3.3 0.0 1.1 11.6 11.2 0.2 73.2 5.1 0.2 0.6 0.0 2.1 1.9 1.1 0.1 2.4 1.1 2.4 0.5 1.9 4.4 0.3 0.6 0.1 7.3 0.0 0.0 0.3 10.1 4.5 4.2 0.1 41.7 62.1 0.2 17.0 0.0 1.2 0.2 0.1 0.0 23.2 0.0 26.7 1.4 17.4 16.0 0.0 0.1 5.4 11.5 0.5 6.5 0.1 0.7 16.3 4.7 19.9 11.7 51.1 13.1 3.7 12.6 7.8 36.0 5.9 4.5 49.6 4.2 32.5 41.7 31.7 2125.3 23.4 185.2 30.1 17.0 55.2 167.5 24.7 16.1 26.3 30.0 23.4 58.8 454.5 0.7 185.3 1.4 13.7 21.4 148.8 26.9 52.9 40.8 18.5 42.5 627.1 12.3 1.9 69.4 11.7 36.1 2.5 7.9 34.2 97.2 0.8 126.2 1056.8 3.3 10.2 9.1 35.8 97.1 46.6 8.3 60.5 757.0 4.7 50.4 250.3 1524.0 114.9 8.2 0.5 87.3 88.7 24.0 0.7 44.6 16.0 160.0 39.5 57.9 32.2 1.9 3.8 73.2 423.4 4.7 237.6 11.5 2.1 61.9 RPAP2 "C1orf82, FLJ13150, Rtr1" ENSG00000122484 "RNA polymerase II associated protein 2" Q8IXW5 1 92299059-92402056 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Transcription, Transcription regulation" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 12.6" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046443 Approved Supported Nucleoli,Cytosol No No "Cluster 11: Basophils - Unknown function" "Cluster 6: Brain - Smell perception" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 52: Non-specific - Transcription" "Nucleoli, Cytosol" "HPA046443: AB_2679669" "unprognostic (1.29e-1)" "unprognostic (2.52e-1)" "unprognostic (3.71e-2)" "unprognostic (4.12e-2)" "unprognostic (4.96e-3)" "unprognostic (5.73e-2)" "unprognostic (1.23e-3)" "unprognostic (3.29e-2)" "unprognostic (8.01e-3)" "unprognostic (4.09e-2)" "unprognostic (2.59e-1)" "unprognostic (6.09e-2)" "unprognostic (7.02e-4)" "unprognostic (1.18e-2)" "unprognostic (1.69e-1)" "unprognostic (3.62e-3)" "unprognostic (4.10e-2)" 1.4 1.9 3.2 2.2 4.1 3.9 2.2 12.6 8.7 1.6 0.3 1.4 1.8 2.1 3.2 1.3 1.4 1.5 1.6 3.3 0.9 2.2 3.0 1.4 2.6 1.2 0.2 2.1 2.5 2.0 1.7 1.5 1.8 2.1 1.6 9.3 2.1 1.3 3.0 3.2 1.7 1.5 0.2 2.3 1.8 2.0 1.8 2.8 2.7 2.3 1.9 1.4 1.1 8.4 4.0 2.3 4.1 3.8 3.3 4.2 3.4 3.0 2.1 2.0 1.6 1.7 1.7 5.9 5.1 2.3 2.7 2.7 3.4 1.9 3.0 4.0 2.4 3.5 4.6 2.3 1.9 6.3 3.4 2.1 2.4 2.5 2.5 2.9 2.1 3.6 3.7 3.7 3.0 2.0 5.4 3.9 3.1 2.2 2.7 3.9 5.4 2.5 2.6 3.4 3.8 2.7 4.4 4.5 2.5 3.0 2.3 4.7 3.6 2.8 3.7 3.3 4.4 3.7 4.5 3.0 2.0 3.9 1.9 1.9 0.7 0.6 1.3 0.5 1.5 1.1 1.0 1.1 0.6 1.3 1.0 1.2 1.4 1.3 0.7 1.1 1.0 0.4 3.2 4.1 12.6 8.7 3.3 0.9 1.2 0.2 1.8 0.2 1.8 8.4 23.1 64.1 78.5 66.9 20.1 9.2 16.7 15.7 23.9 63.6 16.3 16.5 24.7 10.0 44.5 7.3 110.5 21.3 31.5 6.4 11.7 19.2 68.1 18.8 48.6 23.4 12.6 13.3 97.1 13.6 14.2 24.8 13.3 17.6 62.0 37.7 9.3 8.0 9.7 35.3 91.3 13.3 14.2 8.7 4.6 9.7 19.0 15.6 1.8 43.1 16.6 31.4 42.2 68.3 78.8 13.8 13.6 21.4 28.5 15.9 11.9 15.6 45.0 95.2 26.3 44.4 20.3 27.3 20.0 16.8 9.8 23.7 35.8 42.3 12.1 10.4 RPS6KA1 "HU-1, MAPKAPK1, p90Rsk, RSK1" ENSG00000117676 "Ribosomal protein S6 kinase A1" Q15418 1 26529761-26575030 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 91.1;monocytes: 81.2;NK-cells: 88.6;Proximal enterocytes: 93.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HMC-1: 77.6;U-937: 86.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003852, HPA007981" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 64: Macrophages - Immune response" "Cluster 32: U-937 - Innate immune response" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol Nucleoplasm "CAB003852: AB_289590, HPA007981: AB_1079850" "unprognostic (1.04e-3)" "unprognostic (1.23e-1)" "unprognostic (1.61e-3)" "prognostic favorable (7.20e-7)" "unprognostic (7.35e-2)" "unprognostic (3.69e-1)" "unprognostic (6.93e-3)" "unprognostic (1.12e-2)" "unprognostic (1.09e-1)" "unprognostic (7.51e-3)" "unprognostic (2.37e-2)" "unprognostic (9.64e-2)" "prognostic favorable (1.84e-4)" "prognostic favorable (4.58e-4)" "unprognostic (4.77e-2)" "unprognostic (7.61e-2)" "prognostic favorable (8.33e-4)" 7.4 17.0 7.8 17.5 9.1 23.8 8.3 9.2 9.3 6.0 11.2 37.9 33.1 3.0 1.2 16.9 7.9 5.5 3.8 7.9 9.1 26.2 10.5 33.7 20.2 10.8 9.5 1.9 19.4 12.5 13.4 4.0 10.1 17.2 20.7 1.4 21.5 4.5 1.7 17.8 51.4 3.6 9.4 47.1 20.6 5.4 10.4 11.4 24.5 1.9 20.7 9.0 9.6 11.6 27.1 9.3 7.5 9.9 0.4 0.1 9.9 2.2 4.2 11.0 10.6 10.8 21.9 50.2 11.9 1.3 13.3 31.0 16.9 61.0 7.8 41.8 11.0 55.3 21.6 19.5 3.4 65.8 77.6 1.8 22.1 10.1 18.0 5.0 4.9 19.7 9.6 17.7 0.6 15.0 2.4 64.3 19.1 52.2 29.2 34.8 9.5 22.0 31.7 7.3 10.7 4.4 18.7 17.5 8.4 7.8 11.2 55.5 3.2 0.5 13.9 1.8 9.2 10.9 14.0 27.5 6.5 86.8 10.8 37.6 57.9 131.2 24.2 52.1 20.3 14.2 17.9 21.6 68.8 15.7 11.3 15.8 108.2 26.4 58.4 26.9 19.0 65.2 7.8 9.1 9.2 9.3 7.9 9.1 10.8 9.5 10.1 9.4 10.4 11.6 2.8 16.0 25.0 0.0 23.7 18.6 8.1 19.9 16.5 1.5 12.0 10.4 1.3 11.5 7.7 9.2 4.2 1.6 53.9 91.1 7.9 16.3 1.9 19.9 2.2 6.9 16.3 29.5 1.4 18.7 17.5 1.8 18.3 20.7 31.8 3.3 7.9 3.4 47.5 0.0 2.6 41.6 12.2 53.0 14.2 1.4 0.0 44.1 1.8 12.2 81.2 0.6 88.6 1.0 12.3 28.1 41.9 0.0 14.2 18.8 93.3 17.2 13.6 1.8 6.6 0.8 2.7 1.6 3.4 10.9 11.6 4.1 36.3 2.0 43.6 9.1 RPS6KA2 "HU-2, RSK3" ENSG00000071242 "Ribosomal protein S6 kinase A2" Q15349 6 166409364-166906451 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 399.6;Excitatory neurons: 204.1;Horizontal cells: 287.7;Inhibitory neurons: 552.3;Oligodendrocyte precursor cells: 244.8" "Cancer enhanced" "Detected in all" "thyroid cancer: 26.9" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 5 "eosinophil: 22.4" "Lineage enriched" "Detected in many" 5 "granulocytes: 22.4" "Cell line enhanced" "Detected in many" "ASC diff: 214.5;ASC TERT1: 156.1;HHSteC: 158.5;HSkMC: 141.4;hTERT-HME1: 173.0;hTERT-RPE1: 316.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB026243, HPA045061, HPA054237, CAB069428" Approved Supported Nucleoplasm NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "CAB026243: , CAB069428: AB_1622639, HPA045061: AB_2679203, HPA054237: AB_2682425" "unprognostic (8.71e-2)" "unprognostic (3.14e-3)" "unprognostic (7.29e-2)" "unprognostic (1.72e-1)" "unprognostic (3.80e-1)" "unprognostic (2.45e-1)" "unprognostic (6.44e-3)" "unprognostic (8.63e-2)" "unprognostic (1.40e-1)" "prognostic unfavorable (8.63e-5)" "unprognostic (8.68e-2)" "unprognostic (4.11e-2)" "prognostic favorable (2.86e-5)" "unprognostic (3.12e-3)" "unprognostic (1.51e-1)" "unprognostic (1.56e-2)" "unprognostic (2.01e-1)" 34.2 9.0 40.3 8.0 41.0 10.5 27.8 35.0 35.2 18.1 8.6 16.6 6.1 26.0 7.1 20.1 18.7 18.2 61.8 37.8 42.1 13.6 6.6 45.1 7.5 48.3 41.7 29.2 19.4 49.6 27.2 17.9 42.0 14.9 10.3 28.9 14.7 14.2 24.1 16.4 16.5 22.7 35.3 26.0 21.4 7.7 47.3 5.9 36.3 30.5 7.3 24.5 14.9 49.3 9.1 0.0 17.9 26.0 214.5 156.1 0.4 19.3 37.4 10.6 14.6 0.0 5.8 1.1 6.2 68.2 8.4 8.2 9.4 41.8 9.4 4.2 2.3 0.1 40.2 0.4 158.5 0.6 7.2 141.4 29.4 56.6 173.0 316.2 58.0 19.2 0.2 0.2 43.6 1.9 0.8 2.1 4.5 9.1 10.5 3.0 9.2 27.3 11.1 10.1 9.8 68.8 6.7 17.9 24.8 4.4 0.5 14.3 21.7 37.3 3.7 103.8 5.6 5.2 8.4 2.6 24.8 1.2 36.0 0.2 0.6 22.4 0.6 0.8 0.3 0.3 0.6 0.3 0.8 0.5 0.7 0.3 0.5 4.4 2.2 4.7 0.5 0.4 40.3 41.0 35.0 35.2 37.8 42.1 48.3 41.7 42.0 35.3 47.3 49.3 60.9 22.4 46.2 399.6 2.7 4.7 5.4 4.6 3.4 37.1 7.1 5.0 60.0 15.7 11.6 36.8 8.4 0.2 8.0 1.9 11.7 15.2 14.8 20.6 4.6 58.2 5.4 0.0 204.1 24.0 0.3 16.3 16.8 20.3 2.5 10.5 45.3 11.9 7.2 287.7 552.3 5.3 2.0 6.0 6.7 69.3 5.3 8.0 19.6 144.3 3.5 10.1 1.0 244.8 97.7 26.8 1.7 4.5 2.4 9.9 0.3 7.0 9.4 17.1 13.1 10.0 14.5 3.5 2.3 1.2 3.4 0.3 2.0 9.5 1.4 6.6 RPS6KA3 "CLS, HU-3, MRX19, RSK2" ENSG00000177189 "Ribosomal protein S6 kinase A3" P51812 X 20149911-20267519 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Cell cycle, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Hep G2: 236.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003221, CAB003853, CAB013520" Approved Supported Nucleoplasm,Nucleoli,Cytosol No No "Cluster 46: Basophils - DNA binding" "Cluster 8: Non-specific - Mitochondria" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "Nucleoli, Cytosol" "CAB003853: AB_562343, CAB013520: AB_2533378, HPA003221: AB_1853553" "unprognostic (1.87e-2)" "unprognostic (1.03e-1)" "unprognostic (1.80e-2)" "unprognostic (4.26e-2)" "unprognostic (3.53e-1)" "unprognostic (1.11e-1)" "unprognostic (1.15e-2)" "unprognostic (1.61e-3)" "unprognostic (1.02e-1)" "unprognostic (1.57e-1)" "unprognostic (5.04e-1)" "unprognostic (1.07e-1)" "unprognostic (1.04e-1)" "unprognostic (4.49e-3)" "unprognostic (3.91e-1)" "unprognostic (1.09e-1)" "unprognostic (2.22e-1)" 21.1 18.8 6.9 33.7 10.2 16.2 14.8 12.7 12.8 16.1 8.5 32.8 24.1 17.5 8.5 18.7 15.1 26.9 21.1 8.7 9.4 19.5 45.0 32.3 31.3 8.4 10.0 10.6 17.2 59.4 5.9 19.5 8.5 19.9 31.8 15.7 13.2 18.0 51.8 15.0 27.6 27.8 8.7 29.2 21.1 5.5 10.6 32.9 21.2 40.3 32.6 34.2 8.5 8.0 44.9 77.0 28.4 14.8 27.1 47.3 8.6 38.0 57.4 27.8 37.7 87.7 56.2 29.3 12.8 40.0 40.5 30.9 32.8 32.2 51.1 24.8 26.1 34.6 46.2 236.8 27.7 67.8 34.2 30.3 25.1 43.5 54.4 24.3 101.9 30.4 23.1 81.0 29.4 21.2 44.2 20.7 20.6 57.8 45.9 23.3 60.0 33.8 23.9 36.9 13.1 12.8 51.1 15.3 54.4 35.3 0.1 20.0 57.3 30.1 20.8 96.3 21.7 64.3 42.1 32.1 56.9 33.1 72.6 11.9 3.8 7.9 4.7 5.3 8.3 2.4 5.4 5.2 5.6 3.2 3.7 4.5 5.8 6.6 6.0 6.7 2.9 2.2 6.9 10.2 12.7 12.8 8.7 9.4 8.4 10.0 8.5 8.7 10.6 8.0 60.6 44.8 67.5 31.6 34.8 54.4 37.0 21.2 10.2 37.8 20.4 10.8 22.9 34.3 41.1 16.5 22.9 4.0 70.0 63.5 3.9 26.3 0.4 10.8 24.0 61.1 25.0 19.1 142.2 30.5 6.7 31.6 24.5 26.1 44.3 8.3 34.6 65.4 22.6 13.5 108.4 59.1 28.5 40.8 104.3 1.5 13.1 62.6 37.4 126.5 53.7 27.5 46.4 116.6 27.0 37.4 57.9 21.1 25.5 56.6 33.5 25.1 23.3 9.7 19.7 41.5 21.3 6.4 8.7 13.8 55.5 3.6 66.0 14.2 61.1 63.8 RPS6KA4 "MSK2, RSK-B" ENSG00000162302 "Ribosomal protein S6 kinase A4" O75676 11 64359148-64372215 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Inflammatory response, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 70.0;dendritic cells: 75.0;Pancreatic endocrine cells: 65.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "plasmacytoid DC: 10.5" "Group enriched" "Detected in many" 5 "dendritic cells: 10.5;monocytes: 2.7" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008649, HPA023225" Approved Supported Nucleoplasm,Cytosol No No "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 18: U-2197 - ECM organization" "Cluster 47: Cytotrophoblasts - Unknown function" Nucleoplasm Cytosol "CAB008649: AB_1619460, HPA023225: AB_1854144" "unprognostic (2.30e-1)" "unprognostic (7.05e-2)" "unprognostic (2.03e-1)" "unprognostic (4.07e-2)" "unprognostic (2.40e-1)" "unprognostic (7.47e-2)" "prognostic unfavorable (8.17e-4)" "prognostic unfavorable (9.27e-4)" "unprognostic (2.45e-1)" "unprognostic (9.03e-2)" "unprognostic (1.41e-2)" "unprognostic (3.06e-3)" "unprognostic (1.98e-2)" "unprognostic (3.93e-3)" "unprognostic (5.25e-2)" "unprognostic (1.09e-1)" "unprognostic (2.85e-1)" 15.0 13.1 14.8 11.8 16.1 10.9 12.5 17.0 17.9 13.7 10.5 16.8 9.8 16.5 2.8 31.0 12.0 4.7 16.2 15.3 13.7 14.2 12.0 16.4 12.0 14.7 14.7 8.5 12.2 3.3 6.8 11.7 14.7 13.1 5.6 2.1 12.5 5.6 16.0 22.8 17.1 6.8 14.4 25.0 15.8 3.5 15.1 5.7 10.2 5.0 9.5 16.6 14.6 14.3 76.1 41.5 5.9 15.0 12.8 11.9 84.0 39.4 20.6 30.2 14.9 41.7 38.8 7.9 44.9 22.9 38.6 69.1 7.1 32.1 14.7 24.1 14.0 17.8 36.8 21.6 12.8 18.0 32.0 12.0 29.7 25.7 20.9 10.9 18.4 14.2 7.4 10.6 15.6 69.2 16.6 28.4 6.5 29.2 88.1 31.8 24.4 25.3 21.1 34.4 8.7 6.9 40.7 24.8 35.6 8.5 28.6 22.3 37.0 41.0 51.7 74.7 35.9 12.5 10.4 7.8 27.0 20.6 21.2 1.3 2.7 1.4 0.7 2.1 0.7 0.4 0.5 0.6 2.2 0.2 0.3 0.3 0.2 0.2 1.3 10.5 0.5 2.6 14.8 16.1 17.0 17.9 15.3 13.7 14.7 14.7 14.7 14.4 15.1 14.3 11.8 3.2 3.0 8.5 6.4 12.1 6.8 8.6 8.6 7.3 5.4 4.8 15.2 7.2 5.4 3.7 4.2 70.0 75.0 25.2 5.9 20.1 0.8 3.5 8.7 9.9 8.4 9.9 6.6 25.2 38.2 9.3 26.0 7.6 19.1 5.7 10.8 7.8 29.6 8.4 5.3 14.3 2.0 30.5 13.2 1.5 11.1 25.8 8.8 11.2 26.6 3.6 10.3 4.5 5.4 65.1 12.8 6.8 5.7 10.2 16.2 8.4 3.1 2.1 0.0 6.0 10.2 0.7 6.5 13.9 10.7 46.7 11.3 7.5 19.9 9.6 RPS6KA5 "MSK1, RLPK" ENSG00000100784 "Ribosomal protein S6 kinase A5" O75582 14 90847861-91060641 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Inflammatory response, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Glandular and luminal cells: 162.0;Oligodendrocytes: 156.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HMC-1: 31.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001274, HPA001780, CAB025458" Approved Enhanced Nucleoplasm NA NA "Cluster 38: Basophils - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 3: HMC-1 - Innate immune response" "Cluster 44: Endometrium - Transcription" Nucleoplasm "CAB025458: , HPA001274: AB_1079417, HPA001780: AB_2666432" "unprognostic (3.05e-2)" "unprognostic (2.19e-3)" "unprognostic (4.27e-4)" "unprognostic (1.98e-3)" "unprognostic (4.79e-2)" "unprognostic (4.20e-4)" "unprognostic (3.70e-2)" "unprognostic (5.80e-4)" "unprognostic (6.70e-2)" "unprognostic (8.39e-2)" "unprognostic (1.84e-1)" "unprognostic (1.97e-1)" "unprognostic (1.38e-4)" "unprognostic (5.73e-3)" "unprognostic (1.07e-1)" "unprognostic (2.42e-1)" "unprognostic (1.75e-1)" 2.6 0.9 2.4 2.9 7.8 3.3 7.5 14.7 3.7 3.1 1.0 6.6 3.7 4.9 0.3 5.3 4.1 2.8 2.6 1.6 3.0 1.9 1.7 2.8 3.4 4.1 3.8 4.6 1.5 3.0 2.6 3.4 4.1 3.1 5.1 3.0 4.9 4.3 9.0 3.7 4.9 3.9 2.9 3.1 5.4 2.4 4.5 5.0 4.0 9.9 3.5 5.4 4.1 8.0 1.3 2.1 2.7 1.4 0.0 0.5 9.4 0.9 1.3 2.9 4.1 1.2 2.7 6.7 2.8 2.8 1.8 4.7 2.2 1.8 5.1 1.0 3.5 7.5 1.8 0.4 0.0 7.1 31.8 0.8 4.3 1.7 1.3 0.7 3.2 5.1 0.7 7.1 2.9 3.1 2.0 2.2 0.9 4.6 3.4 3.3 11.2 3.2 3.2 2.9 10.4 3.2 2.7 14.8 8.1 1.8 3.0 1.9 0.6 0.8 1.5 0.6 3.4 2.8 3.5 5.9 1.7 5.0 10.6 16.9 3.0 9.0 3.7 2.5 6.1 4.5 4.6 3.5 2.7 5.8 5.5 3.0 19.8 10.4 3.5 1.2 7.9 2.6 2.4 7.8 14.7 3.7 1.6 3.0 4.1 3.8 4.1 2.9 4.5 8.0 13.2 19.2 26.5 80.3 53.7 40.4 45.2 20.4 53.5 32.9 41.4 42.9 20.7 14.3 22.7 7.3 16.7 43.7 21.0 36.7 0.0 11.1 9.1 96.2 19.0 21.4 16.3 22.5 65.4 5.1 6.5 21.8 13.3 162.0 92.2 32.5 20.3 6.5 7.1 26.9 32.5 17.3 4.1 17.6 13.4 3.1 14.0 21.8 19.6 53.4 21.2 10.5 23.7 36.7 156.1 3.5 13.0 11.7 26.0 29.3 41.9 3.7 31.3 32.1 13.1 51.9 22.3 21.2 23.7 35.5 46.3 111.8 48.6 7.2 20.8 52.7 RPS6KA6 RSK4 ENSG00000072133 "Ribosomal protein S6 kinase A6" Q9UK32 X 84058346-84188199 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 75.3;Inhibitory neurons: 70.7;Oligodendrocyte precursor cells: 31.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "NTERA-2: 8.1;PC-3: 7.9;RH-30: 9.9;SH-SY5Y: 9.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002852, HPA003904" Uncertain Supported Nucleoplasm,Nucleoli,Mitochondria NA NA "Cluster 35: T-regs - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 5: NTERA-2 - Transcription" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Mitochondria" Nucleoli "HPA002852: AB_1079854, HPA003904: AB_1079853" "unprognostic (1.17e-1)" "unprognostic (1.02e-2)" "unprognostic (3.44e-1)" "unprognostic (4.93e-4)" "unprognostic (1.71e-1)" "unprognostic (3.04e-3)" "unprognostic (2.09e-2)" "unprognostic (2.50e-1)" "unprognostic (2.86e-1)" "unprognostic (4.88e-2)" "unprognostic (3.38e-3)" "unprognostic (2.88e-1)" "unprognostic (2.12e-9)" "unprognostic (4.44e-3)" "unprognostic (1.30e-2)" "unprognostic (2.34e-2)" "unprognostic (8.49e-3)" 0.4 2.0 2.6 0.5 3.1 0.1 1.7 3.2 3.0 2.0 2.6 2.9 1.2 1.7 3.1 0.8 2.2 1.1 0.6 2.7 3.4 5.7 0.6 0.6 0.2 2.7 2.4 2.6 0.9 7.0 5.8 0.3 2.2 2.8 2.3 7.0 1.7 2.7 1.6 2.0 1.3 1.0 1.5 0.4 1.7 1.5 2.4 1.0 8.1 0.4 0.3 1.3 1.4 2.0 0.0 2.4 2.6 0.0 2.4 2.2 0.0 5.2 2.7 2.3 1.9 1.9 2.0 0.0 0.0 2.6 0.0 0.1 6.4 4.6 5.1 0.0 3.5 0.0 0.1 0.0 2.7 0.0 0.0 1.4 0.0 0.0 2.4 3.0 0.6 0.0 0.0 0.1 2.0 0.0 1.1 0.1 8.1 0.0 7.9 0.0 9.9 0.0 0.5 5.4 0.0 9.4 0.0 3.4 0.0 3.8 1.4 0.0 0.0 0.1 2.4 0.0 0.0 0.3 0.0 0.0 0.8 0.0 0.0 0.6 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.6 0.0 2.6 3.1 3.2 3.0 2.7 3.4 2.7 2.4 2.2 1.5 2.4 2.0 0.3 9.6 2.7 6.2 0.7 0.3 5.3 0.3 3.4 21.1 3.6 3.4 2.6 12.8 1.9 18.4 25.0 2.6 0.1 6.7 1.9 0.5 0.7 1.9 1.2 1.2 25.0 2.7 75.3 1.2 0.7 2.2 2.0 0.9 0.0 21.8 1.1 1.3 0.2 1.7 70.7 3.6 0.0 0.0 0.0 0.4 4.4 0.5 0.0 3.7 0.1 2.1 1.0 31.2 5.8 1.3 3.4 6.0 0.0 9.2 1.8 4.3 3.7 18.2 0.0 4.9 1.5 8.4 6.2 2.5 0.4 2.3 0.9 2.0 6.5 5.2 RPS6KB1 "p70(S6K)-alpha, PS6K, S6K, S6K1, STK14A" ENSG00000108443 "Ribosomal protein S6 kinase B1" P23443 17 59893046-59950574 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle, Translation regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 5 "MCF7: 243.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003838, CAB018346, HPA039442" Approved Supported Nucleoplasm NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 52: Non-specific - Ribosome" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 59: Non-specific - Transcription" Nucleoplasm "CAB003838: AB_562325, CAB018346: AB_632156, HPA039442: AB_2676510" "unprognostic (2.25e-1)" "unprognostic (4.52e-2)" "unprognostic (1.91e-3)" "unprognostic (1.35e-2)" "unprognostic (9.81e-2)" "unprognostic (1.13e-1)" "unprognostic (3.72e-3)" "unprognostic (1.70e-1)" "unprognostic (5.86e-2)" "unprognostic (1.66e-1)" "unprognostic (3.67e-1)" "unprognostic (1.76e-2)" "prognostic unfavorable (5.09e-7)" "unprognostic (3.45e-1)" "unprognostic (2.09e-1)" "unprognostic (3.98e-2)" "unprognostic (1.52e-3)" 14.0 11.3 7.1 11.9 7.8 18.0 13.3 11.8 9.8 11.8 9.4 10.7 10.0 13.8 10.1 16.3 10.2 9.4 10.6 7.2 6.6 9.8 15.2 9.9 14.2 7.3 7.0 14.9 16.9 14.9 7.4 15.4 7.5 10.6 11.0 10.9 9.4 10.2 22.7 10.6 9.3 14.3 6.2 12.4 11.1 6.9 7.5 15.2 11.9 18.3 17.3 14.9 11.0 9.6 34.5 33.5 27.5 26.2 18.1 26.2 20.8 31.2 28.3 26.3 29.3 27.6 16.8 41.7 37.9 25.4 32.1 17.3 36.0 27.3 42.7 23.3 41.5 28.7 21.2 31.2 26.9 44.5 27.1 26.7 20.7 31.0 22.8 21.9 35.0 26.0 38.5 25.9 19.7 243.6 53.2 18.4 18.6 29.8 24.9 30.8 46.7 38.8 21.9 25.1 20.1 23.8 26.2 15.2 16.6 31.7 29.7 24.2 31.1 25.8 42.9 21.2 42.0 46.2 42.0 46.3 19.4 26.7 21.2 43.8 12.1 11.4 12.7 12.2 15.5 10.4 11.6 14.7 15.3 9.4 13.5 14.3 11.5 11.9 14.4 9.5 11.9 10.3 7.1 7.8 11.8 9.8 7.2 6.6 7.3 7.0 7.5 6.2 7.5 9.6 22.8 22.4 34.2 29.0 32.6 33.0 21.4 13.0 30.7 18.0 23.1 17.8 16.8 12.8 30.4 3.7 18.8 24.3 33.5 12.4 3.9 12.9 5.1 24.0 31.7 25.5 13.2 11.8 47.3 16.4 18.2 24.8 26.0 37.7 23.4 20.0 13.6 15.1 12.1 18.5 45.2 14.1 4.1 15.2 20.4 3.8 15.8 19.0 10.6 28.1 20.0 12.8 18.6 25.6 54.8 15.1 10.9 18.0 34.6 27.9 9.3 9.2 21.1 18.9 26.3 33.4 32.6 13.0 13.7 34.5 32.0 30.5 29.9 26.0 13.9 25.4 RPS6KB2 "KLS, P70-BETA, p70S6Kb, S6Kβ, S6KB, S6Kbeta, STK14B" ENSG00000175634 "Ribosomal protein S6 kinase B2" Q9UBS0 11 67428460-67435401 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA010010, CAB019404" Approved Supported Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 55: Plasma cells - Humoral immune response" Cytosol "CAB019404: AB_331355, HPA010010: AB_1856469" "unprognostic (1.38e-1)" "unprognostic (2.36e-3)" "unprognostic (8.50e-2)" "unprognostic (2.56e-2)" "unprognostic (1.84e-1)" "unprognostic (1.41e-1)" "unprognostic (9.01e-3)" "unprognostic (5.10e-2)" "unprognostic (1.22e-1)" "unprognostic (9.49e-3)" "unprognostic (7.66e-2)" "unprognostic (2.79e-2)" "prognostic unfavorable (2.03e-7)" "unprognostic (1.28e-2)" "unprognostic (1.55e-1)" "unprognostic (2.12e-1)" "unprognostic (2.66e-1)" 16.2 28.0 9.7 13.8 10.8 28.2 17.0 9.9 12.4 23.5 13.2 22.8 26.5 17.7 6.0 71.9 20.0 10.6 22.1 9.1 9.3 21.3 50.2 19.5 18.4 10.9 10.3 16.2 35.4 17.5 20.6 13.6 10.6 31.6 12.8 4.2 31.5 9.9 37.9 81.6 25.4 10.1 10.2 33.7 35.2 9.6 9.9 24.0 20.1 26.0 20.1 19.3 31.4 11.3 58.2 42.7 22.8 39.0 10.4 20.0 30.0 27.4 33.9 49.7 34.2 67.2 37.5 21.1 46.3 26.9 31.0 41.8 25.9 41.4 19.9 36.9 70.0 34.5 54.2 55.5 35.2 43.7 40.4 25.5 42.8 26.3 26.9 12.5 37.5 54.8 55.8 54.8 25.4 88.5 68.1 68.4 24.9 83.7 54.6 50.0 31.8 100.5 23.0 32.6 34.4 37.1 28.0 76.8 59.8 13.2 90.4 35.7 15.8 25.8 27.6 63.1 31.1 48.8 43.9 34.4 42.4 27.3 33.1 18.8 37.2 28.5 23.8 42.6 24.5 23.4 22.9 23.9 44.1 21.9 16.1 17.9 24.7 29.6 49.9 30.4 34.5 37.3 9.7 10.8 9.9 12.4 9.1 9.3 10.9 10.3 10.6 10.2 9.9 11.3 22.0 9.6 20.5 6.8 48.1 49.8 28.0 48.9 19.9 25.3 32.6 27.8 1.3 28.6 31.2 7.3 10.4 71.8 45.0 66.9 43.0 44.5 14.9 16.0 16.9 17.9 46.2 65.0 7.7 64.8 89.1 21.9 48.9 19.3 27.9 23.2 18.2 57.4 61.3 33.7 7.1 67.7 34.6 45.8 29.1 29.4 20.2 36.9 19.6 3.7 56.6 28.5 73.2 5.0 12.1 46.6 70.4 17.3 82.1 43.7 115.0 42.2 16.0 27.6 19.7 16.7 26.9 15.8 16.0 52.5 63.6 103.6 41.7 27.5 58.3 39.4 RPS6KC1 "humS6PKh1, RSKL1" ENSG00000136643 "Ribosomal protein S6 kinase C1" Q96S38 1 213051233-213274774 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 86.2;Excitatory neurons: 273.2;Inhibitory neurons: 151.2;Microglial cells: 101.2;Oligodendrocyte precursor cells: 116.6;Oligodendrocytes: 137.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 16.8" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026531, HPA031565" Approved Supported Endosomes,Lysosomes NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 78: Testis - Spermatogenesis" "Cluster 3: HMC-1 - Innate immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Endosomes, Lysosomes" "HPA026531: AB_10601497, HPA031565: AB_2673935" "unprognostic (3.90e-2)" "unprognostic (5.90e-2)" "unprognostic (3.22e-1)" "unprognostic (4.88e-2)" "unprognostic (2.42e-1)" "unprognostic (9.81e-2)" "unprognostic (1.32e-2)" "unprognostic (1.64e-1)" "unprognostic (4.10e-2)" "unprognostic (3.34e-1)" "unprognostic (4.18e-1)" "unprognostic (5.11e-2)" "prognostic unfavorable (2.70e-4)" "unprognostic (8.10e-2)" "unprognostic (5.48e-2)" "unprognostic (2.98e-2)" "unprognostic (4.44e-2)" 8.3 8.8 9.7 7.1 11.5 4.9 7.2 8.2 13.9 8.8 4.3 7.8 6.2 9.4 5.2 6.7 7.6 7.7 6.4 12.9 8.8 6.4 7.4 7.1 5.2 8.6 8.8 9.2 9.2 10.2 4.5 8.4 8.6 11.5 6.5 9.3 6.8 11.3 10.0 4.3 6.0 12.6 8.6 7.9 8.6 19.3 9.9 5.4 6.9 11.6 5.4 8.1 4.6 13.2 11.0 9.3 15.0 16.3 15.0 21.6 13.2 14.1 20.7 21.5 24.6 7.7 11.9 6.9 9.3 21.4 14.1 8.9 18.3 11.6 16.2 14.7 6.7 18.7 10.9 10.5 13.6 11.9 21.4 14.3 9.8 18.8 10.2 17.9 18.2 6.7 24.6 10.5 22.3 6.3 5.0 3.9 21.8 9.8 10.4 5.9 14.1 6.8 9.7 10.9 8.7 22.6 15.3 11.9 20.6 25.5 17.1 4.9 17.0 14.6 13.3 16.9 9.3 6.1 12.6 5.2 6.2 4.5 15.2 16.8 4.5 3.5 2.5 6.4 2.1 2.4 2.0 2.2 8.5 1.6 1.3 3.0 0.5 3.8 6.7 1.0 1.6 2.2 9.7 11.5 8.2 13.9 12.9 8.8 8.6 8.8 8.6 8.6 9.9 13.2 10.1 9.6 5.8 86.2 8.8 2.9 2.7 4.5 7.4 17.4 6.6 5.6 9.6 7.2 4.3 0.0 14.6 3.5 7.7 4.8 0.0 5.2 33.6 7.4 12.1 9.9 3.6 12.4 273.2 8.0 4.0 10.1 15.3 9.9 7.6 16.6 7.9 9.3 7.1 20.2 151.2 3.3 6.1 11.4 7.7 45.2 11.1 15.1 7.2 101.2 13.1 5.6 10.3 116.6 137.6 6.6 2.1 7.5 8.1 5.4 4.4 5.7 4.7 20.0 13.1 13.7 9.1 19.6 19.6 9.1 4.4 3.8 10.4 6.1 4.3 3.2 RTCA "RPC, RTC1, RTCD1" ENSG00000137996 "RNA 3'-terminal phosphate cyclase" O00442 1 100266216-100292769 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Ligase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027982, HPA027990, HPA028151, HPA028331" Uncertain Enhanced Nucleoplasm NA NA 38000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 8: Non-specific - Mitochondria" "Cluster 18: U-2197 - ECM organization" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "HPA027982: AB_10601769, HPA027990: AB_2672452, HPA028151: AB_10602099, HPA028331: " "unprognostic (4.79e-2)" "unprognostic (1.17e-2)" "unprognostic (3.97e-2)" "unprognostic (3.82e-2)" "unprognostic (6.76e-2)" "unprognostic (4.12e-2)" "prognostic unfavorable (2.76e-5)" "unprognostic (9.55e-3)" "unprognostic (3.64e-2)" "unprognostic (1.12e-2)" "unprognostic (2.46e-1)" "unprognostic (8.09e-3)" "unprognostic (3.74e-3)" "unprognostic (2.10e-2)" "unprognostic (1.44e-1)" "unprognostic (3.59e-1)" "unprognostic (2.94e-2)" 21.7 20.8 14.1 20.4 15.0 31.9 17.1 14.7 17.0 13.1 15.7 22.2 34.5 12.9 26.6 23.8 12.7 16.7 28.4 15.4 16.3 34.5 22.4 15.8 26.3 15.6 14.0 11.0 24.1 23.7 14.3 23.2 16.2 21.6 23.3 22.3 18.7 14.5 39.3 15.8 31.6 15.5 14.0 21.7 23.9 12.5 15.0 19.2 18.0 35.4 23.4 18.5 15.7 15.7 56.8 28.6 27.8 37.4 34.5 55.4 75.7 65.7 32.0 41.9 35.9 47.0 27.7 57.6 48.4 42.0 51.4 28.0 34.3 31.1 50.2 57.8 28.5 38.0 32.8 59.9 52.9 70.2 57.3 45.5 48.0 54.9 72.5 41.3 52.9 41.1 66.6 84.7 64.1 18.6 36.4 54.3 42.7 40.0 54.8 25.7 49.6 25.5 51.7 45.5 22.2 27.6 42.3 60.5 93.3 43.3 13.2 88.5 45.7 39.2 27.5 62.0 80.1 48.7 51.9 46.3 82.5 60.0 23.7 11.8 10.9 9.4 11.8 14.4 15.5 10.6 11.1 14.2 9.6 9.0 10.2 11.6 5.3 13.5 26.1 9.3 24.7 9.3 14.1 15.0 14.7 17.0 15.4 16.3 15.6 14.0 16.2 14.0 15.0 15.7 20.5 6.4 16.2 15.0 27.1 13.6 13.7 23.2 17.6 24.2 19.8 14.0 52.8 11.5 20.4 18.4 12.5 56.7 30.9 30.5 25.4 42.1 19.3 23.0 17.2 20.7 19.2 25.0 20.7 34.5 85.9 18.8 18.8 24.0 13.3 19.8 21.0 17.4 80.9 21.9 22.2 26.2 20.3 48.8 14.5 9.0 19.3 29.5 16.0 21.5 46.2 25.5 25.7 21.1 33.5 57.3 31.9 12.8 36.0 16.1 79.4 73.9 21.0 29.7 6.6 14.3 20.2 43.0 23.2 21.7 14.6 46.4 32.1 25.7 33.0 20.2 RXRA NR2B1 ENSG00000186350 "Retinoid X receptor alpha" P19793 9 134317098-134440585 "Cancer-related genes, FDA approved drug targets, Metabolic proteins, Nuclear receptors, Predicted intracellular proteins, Transcription factors" "Host-virus interaction, Transcription, Transcription regulation" "DNA-binding, Receptor" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 106.5" "Cell type enhanced" "Detected in many" "Hepatocytes: 218.9;Kupffer cells: 134.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 19.5" "Group enriched" "Detected in many" 5 "granulocytes: 19.5;monocytes: 12.9" "Cell line enhanced" "Detected in many" "HaCaT: 105.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004565, CAB005352" Supported Supported "Nucleoplasm,Golgi apparatus" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 80: Striated muscle - Unknown function" "Cluster 43: THP-1 - Innate immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Nucleoplasm "Golgi apparatus" "CAB004565: AB_2184877, CAB005352: AB_2184874" "unprognostic (2.68e-1)" "unprognostic (7.94e-2)" "unprognostic (3.67e-2)" "unprognostic (7.22e-2)" "unprognostic (2.07e-2)" "unprognostic (6.69e-2)" "unprognostic (1.52e-1)" "unprognostic (2.15e-1)" "unprognostic (3.45e-2)" "unprognostic (1.65e-3)" "prognostic favorable (7.02e-4)" "unprognostic (7.72e-2)" "prognostic unfavorable (5.58e-4)" "unprognostic (1.25e-2)" "unprognostic (2.58e-1)" "unprognostic (1.49e-2)" "unprognostic (2.59e-1)" 40.5 22.7 33.5 14.5 36.4 18.9 11.2 25.5 29.4 12.2 16.9 16.6 25.8 13.5 8.7 28.5 16.5 13.6 19.4 27.1 30.2 16.0 32.9 18.8 8.2 32.9 31.3 21.7 25.4 45.1 3.5 14.5 30.8 15.6 10.0 5.4 21.7 17.1 106.5 88.1 28.0 11.1 30.4 25.1 14.7 7.9 42.7 6.0 17.6 51.9 7.6 16.2 8.2 22.6 19.6 36.4 14.7 21.9 42.8 19.1 66.7 14.1 16.1 9.6 6.5 20.7 28.0 0.0 25.8 22.5 15.1 105.5 7.7 32.8 2.9 26.3 7.2 0.1 47.5 30.0 20.4 18.8 4.8 29.0 52.1 11.5 10.6 12.9 12.8 1.6 26.0 1.1 8.7 61.8 1.1 59.5 17.5 63.4 16.9 7.4 30.3 36.7 12.2 64.3 17.2 10.5 37.3 46.9 10.6 7.1 44.9 78.8 16.5 16.2 23.4 17.4 9.7 1.7 0.2 0.4 11.6 33.9 12.7 1.3 8.1 6.6 1.4 12.9 0.2 0.3 0.9 1.0 3.2 0.1 0.2 1.2 19.5 2.2 11.2 0.7 1.2 3.2 33.5 36.4 25.5 29.4 27.1 30.2 32.9 31.3 30.8 30.4 42.7 22.6 32.1 32.1 22.9 36.2 4.6 34.5 16.5 21.1 12.5 6.0 16.7 14.4 38.8 72.9 26.2 9.2 25.0 30.1 11.0 72.3 1.9 13.9 4.3 19.8 16.6 28.9 9.6 30.9 9.1 14.1 29.5 23.7 17.9 17.4 1.3 21.3 71.0 218.9 31.9 33.7 17.6 21.2 10.2 134.2 30.0 18.8 32.3 50.4 12.4 10.3 80.4 36.5 14.4 29.1 6.0 15.9 32.4 21.1 7.4 17.7 55.6 19.9 34.4 19.9 19.7 34.6 30.6 0.9 9.4 34.4 46.9 23.9 12.6 15.5 27.5 32.8 SAE1 "AOS1, FLJ3091, Sua1" ENSG00000142230 "SUMO1 activating enzyme subunit 1" Q9UBE0 19 47113274-47210636 "Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Ligase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 151.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041906, HPA043552" Supported Enhanced Nucleoplasm,Cytosol NA NA 37000 "Cluster 32: T-cells - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 24: NB-4 - Immune response" "Cluster 12: Non-specific - Cell cycle regulation" "Nucleoplasm, Cytosol" "HPA041906: AB_2677735, HPA043552: AB_2678548" "unprognostic (9.69e-3)" "unprognostic (1.96e-2)" "unprognostic (1.08e-1)" "unprognostic (1.68e-1)" "unprognostic (1.37e-1)" "unprognostic (2.49e-1)" "prognostic unfavorable (5.49e-8)" "unprognostic (9.86e-2)" "unprognostic (1.62e-2)" "unprognostic (1.58e-1)" "unprognostic (1.93e-3)" "unprognostic (1.58e-1)" "prognostic unfavorable (8.15e-5)" "unprognostic (1.80e-1)" "unprognostic (1.24e-1)" "prognostic unfavorable (2.76e-4)" "unprognostic (1.27e-1)" 43.9 34.7 33.1 18.7 33.9 21.5 38.9 30.2 39.9 47.8 29.7 115.7 9.9 58.5 4.9 53.0 44.5 14.7 44.3 34.2 34.3 29.4 32.4 39.5 23.1 33.4 33.5 36.4 29.3 22.1 27.2 21.6 33.4 38.5 15.8 11.0 31.0 22.3 53.6 41.3 43.2 27.6 30.5 51.8 59.1 76.6 35.6 36.5 50.8 17.7 24.9 68.1 42.3 34.4 126.7 71.6 189.2 81.8 57.9 68.8 51.3 180.7 130.3 154.7 192.7 76.0 61.6 131.4 72.6 112.0 89.6 49.4 179.6 93.2 141.0 138.4 172.0 117.4 45.2 62.7 68.4 142.3 81.7 64.0 42.2 75.4 72.0 58.9 142.2 141.3 138.7 51.3 135.9 68.0 127.1 396.8 87.3 116.0 68.5 171.7 110.2 47.9 56.2 77.1 59.9 79.3 126.8 87.9 79.3 84.3 70.8 75.9 72.7 71.0 103.8 47.0 161.9 97.0 352.1 206.5 44.7 108.7 98.5 55.3 37.6 21.7 41.6 34.7 45.2 37.2 50.4 43.2 45.2 29.6 69.9 54.6 18.9 63.8 23.6 30.1 69.4 65.3 33.1 33.9 30.2 39.9 34.2 34.3 33.4 33.5 33.4 30.5 35.6 34.4 29.2 9.6 18.7 11.4 24.1 25.6 32.6 33.2 16.5 20.1 19.2 16.3 21.9 15.7 18.6 12.9 6.2 77.7 20.5 18.5 11.7 41.6 13.1 13.3 34.4 39.4 19.2 36.6 20.9 34.9 107.2 30.8 17.3 22.0 15.2 40.2 22.1 21.0 57.6 20.2 21.8 25.2 42.7 17.2 25.0 19.1 15.5 19.2 46.2 10.3 48.5 25.8 41.2 10.6 16.3 38.1 20.1 18.8 26.3 32.6 11.4 15.6 7.2 16.6 52.6 16.5 39.0 151.3 113.7 22.4 24.6 57.5 33.5 35.4 32.5 30.5 SAP130 FLJ12761 ENSG00000136715 "Sin3A associated protein 130" Q9H0E3 2 127941217-128028120 "Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" Repressor "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 47.3" "Cell type enhanced" "Detected in many" "Early spermatids: 71.5;Late spermatids: 44.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA034664 Supported "Nuclear speckles" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" "Nuclear speckles" "HPA034664: AB_10603238" "unprognostic (2.17e-2)" "unprognostic (1.96e-2)" "unprognostic (1.85e-1)" "unprognostic (1.33e-1)" "unprognostic (5.45e-2)" "unprognostic (1.65e-1)" "prognostic unfavorable (7.89e-4)" "unprognostic (2.75e-1)" "unprognostic (1.30e-2)" "unprognostic (1.43e-1)" "unprognostic (3.92e-2)" "unprognostic (6.77e-2)" "unprognostic (3.75e-2)" "unprognostic (5.26e-2)" "unprognostic (4.41e-1)" "unprognostic (2.13e-1)" "unprognostic (1.13e-1)" 9.1 8.6 8.8 8.7 8.5 21.7 8.2 8.5 10.2 10.5 5.1 10.3 8.3 10.4 9.2 10.4 9.6 7.2 8.5 8.1 10.8 7.2 8.3 8.0 10.0 6.4 7.9 11.2 8.7 12.4 14.5 9.0 7.1 8.7 9.7 8.6 9.1 7.9 11.9 12.9 9.8 10.2 6.1 8.5 9.7 47.3 8.0 14.8 8.8 13.0 12.6 9.5 10.3 8.8 35.3 18.9 35.3 28.6 22.9 15.7 38.5 22.0 21.4 33.4 26.2 45.1 14.4 29.4 19.3 25.0 17.4 24.0 39.3 22.7 34.5 16.3 25.2 29.2 16.7 35.9 27.5 25.5 22.2 14.8 16.7 44.1 27.5 17.6 27.0 24.4 35.9 21.1 28.2 39.3 35.6 20.0 36.6 20.7 21.1 24.3 29.0 19.6 17.9 30.7 18.5 22.3 23.2 21.7 13.6 22.1 16.4 17.3 23.2 32.1 34.5 30.1 23.6 29.3 31.2 34.3 26.4 17.0 21.0 2.3 4.2 4.6 5.3 2.7 4.0 2.0 3.8 3.5 3.4 5.0 2.7 3.1 14.0 3.6 8.6 6.2 2.7 3.8 8.8 8.5 8.5 10.2 8.1 10.8 6.4 7.9 7.1 6.1 8.0 8.8 5.4 0.0 10.9 29.0 7.9 7.9 2.3 3.2 5.7 5.2 6.5 5.3 15.2 2.8 3.1 1.8 8.4 11.9 9.4 13.1 0.0 4.9 71.5 4.6 8.6 6.2 6.7 11.6 25.4 4.7 12.8 5.2 8.6 8.7 1.3 5.3 5.3 5.8 7.8 8.4 28.9 7.0 4.1 8.4 6.3 44.2 8.4 7.0 5.4 16.9 4.9 5.0 6.2 26.2 31.0 6.1 7.8 8.2 13.2 4.9 6.5 3.4 4.0 5.8 6.6 4.4 5.5 31.0 17.9 9.2 10.4 19.3 7.6 3.7 7.8 4.3 SBK1 Sbk ENSG00000188322 "SH3 domain binding kinase 1" Q52WX2 16 28259246-28323849 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 26.8;skeletal muscle: 44.1" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 81.3;Excitatory neurons: 38.2;Granulosa cells: 26.3;NK-cells: 36.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "AF22: 28.8;AN3-CA: 20.9;NTERA-2: 29.6;REH: 32.6;SCLC-21H: 45.5;SH-SY5Y: 42.6" "Region enriched" "Detected in all" 5 "cerebellum: 275.9" "Low region specificity" "Detected in all" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 80: Striated muscle - Unknown function" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 40: Granulosa cells - Unknown function" "unprognostic (5.15e-2)" "prognostic favorable (6.88e-4)" "unprognostic (2.08e-1)" "unprognostic (6.22e-2)" "unprognostic (1.81e-1)" "unprognostic (1.71e-2)" "unprognostic (5.71e-3)" "unprognostic (3.66e-3)" "unprognostic (1.17e-1)" "unprognostic (1.62e-2)" "unprognostic (2.87e-2)" "unprognostic (6.38e-2)" "unprognostic (1.19e-3)" "unprognostic (3.99e-2)" "unprognostic (3.50e-2)" "unprognostic (7.91e-2)" "unprognostic (5.03e-3)" 0.1 2.4 8.0 0.9 7.0 1.3 0.8 26.8 15.0 0.7 0.0 0.3 0.3 0.9 0.4 0.6 0.7 0.2 2.1 11.6 6.7 1.8 0.2 0.8 1.7 6.6 7.6 0.5 1.9 2.9 5.6 0.0 6.7 1.5 0.3 5.0 2.7 0.2 44.1 1.1 0.6 0.1 3.2 1.9 0.8 2.5 12.8 10.0 2.5 9.1 0.8 0.3 0.3 7.9 0.3 0.4 28.8 20.9 0.0 0.0 4.5 0.0 0.0 0.1 0.0 0.2 1.4 0.7 0.2 0.0 0.4 0.5 8.8 0.2 0.1 3.0 1.2 0.1 0.3 0.9 0.0 0.1 0.5 0.0 0.3 0.0 0.0 0.2 0.2 11.2 0.0 1.8 0.0 3.6 14.0 0.3 29.6 1.9 0.2 32.6 1.6 0.6 0.1 1.8 45.5 42.6 0.8 2.7 0.4 3.5 3.3 0.1 0.8 0.1 4.3 0.4 0.2 0.3 0.0 0.5 0.1 0.5 1.6 0.3 0.0 0.0 1.5 0.0 0.5 0.0 0.4 0.8 0.0 0.1 0.4 1.0 0.0 0.7 0.0 0.0 0.5 0.1 8.0 7.0 26.8 15.0 11.6 6.7 6.6 7.6 6.7 3.2 12.8 7.9 0.2 3.2 0.5 1.0 0.6 0.6 0.7 1.4 3.4 13.0 6.3 2.9 3.6 2.8 2.5 0.0 81.3 0.0 11.1 0.1 1.9 8.2 1.2 2.4 0.3 0.3 6.0 0.4 38.2 5.6 0.0 0.4 0.0 1.8 0.0 26.3 0.0 0.2 0.1 0.0 13.8 0.8 4.1 0.0 0.8 3.9 0.6 0.4 0.0 0.0 0.7 4.1 36.0 5.0 1.7 3.6 0.0 0.0 2.3 1.5 0.1 0.7 1.7 2.7 0.0 2.5 2.7 2.4 2.1 1.0 0.1 0.1 5.6 0.2 1.2 0.4 SCLY SCL ENSG00000132330 "Selenocysteine lyase" Q96I15 2 238060924-238099413 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lyase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 39.1" "Group enriched" "Detected in many" 13 "Early spermatids: 90.6;Late spermatids: 156.3" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020190, HPA055760" Uncertain Enhanced "Golgi apparatus" NA NA 300000 "Cluster 26: Non-specific - Mitochondria" "Cluster 29: Non-specific - Vesicular transport" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 31: Spermatids - Spermatogenesis" "Golgi apparatus" "HPA020190: , HPA055760: AB_2682910" "unprognostic (7.39e-3)" "unprognostic (1.43e-1)" "unprognostic (3.29e-2)" "unprognostic (8.65e-5)" "unprognostic (8.96e-2)" "unprognostic (9.85e-3)" "unprognostic (1.14e-3)" "unprognostic (4.24e-2)" "unprognostic (1.59e-2)" "unprognostic (8.38e-2)" "unprognostic (3.98e-3)" "unprognostic (1.03e-2)" "unprognostic (1.02e-3)" "unprognostic (3.73e-1)" "unprognostic (4.37e-2)" "unprognostic (2.50e-3)" "unprognostic (1.98e-1)" 5.1 4.3 7.2 5.3 9.4 5.0 4.9 9.4 9.3 6.8 6.4 7.3 8.5 8.1 5.6 5.9 6.3 3.8 8.1 6.8 8.2 12.9 39.1 4.7 5.7 9.2 8.8 6.3 22.8 6.1 5.0 2.0 9.4 5.9 3.2 4.6 4.4 4.1 6.4 3.5 8.6 3.9 7.3 7.2 5.8 16.8 8.3 5.9 7.2 3.5 4.3 7.8 5.1 10.4 11.1 19.1 11.9 31.1 9.0 6.4 23.2 11.2 5.6 11.3 14.3 11.6 8.0 18.9 3.3 5.9 35.4 16.4 44.1 21.5 10.9 21.2 41.8 21.1 24.0 37.6 16.7 17.6 18.2 7.1 11.6 21.3 22.0 5.1 21.0 26.1 38.0 5.1 11.7 16.9 17.9 33.0 36.4 16.0 15.6 22.0 23.3 18.2 11.3 3.6 13.1 28.9 12.0 19.4 20.6 8.2 6.3 26.5 8.5 16.3 11.8 24.2 23.7 14.2 13.3 9.3 11.3 37.0 14.4 1.1 3.2 4.0 2.6 2.3 2.0 2.6 3.1 4.4 3.3 1.6 2.3 2.6 0.5 2.9 3.5 0.6 3.2 2.8 7.2 9.4 9.4 9.3 6.8 8.2 9.2 8.8 9.4 7.3 8.3 10.4 2.2 0.0 0.0 0.0 4.6 1.7 2.4 1.9 5.7 5.4 1.7 1.9 2.6 1.5 1.2 0.0 8.4 1.4 3.4 1.9 3.9 5.3 90.6 1.7 3.4 2.4 2.4 9.4 0.0 3.7 2.1 1.9 5.1 2.6 0.0 3.5 1.8 3.3 4.0 6.7 0.0 3.3 8.2 0.9 3.2 156.3 3.1 2.1 1.8 0.0 2.7 2.6 2.1 0.0 0.0 3.0 5.0 0.0 4.9 1.9 3.9 2.7 1.9 6.9 0.0 1.9 3.2 6.2 5.6 3.4 1.6 0.7 4.4 2.2 4.8 1.8 SETD5 FLJ10707 ENSG00000168137 "SET domain containing 5" Q9C0A6 3 9397615-9479240 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Transferase" "Autism, Autism spectrum disorder, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocyte precursor cells: 263.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017093, HPA035574" Approved Enhanced Nucleoplasm NA NA "Cluster 15: NK-cells - Transcription" "Cluster 51: Non-specific - Unknown function" "Cluster 28: BEWO - Transcription regulation" "Cluster 68: Oligodendrocytes - Mixed function" Nucleoplasm "CAB017093: , HPA035574: AB_2674681" "unprognostic (6.46e-2)" "unprognostic (1.64e-1)" "unprognostic (3.44e-1)" "unprognostic (1.13e-1)" "unprognostic (1.22e-1)" "unprognostic (7.99e-2)" "prognostic unfavorable (6.21e-4)" "unprognostic (5.52e-2)" "unprognostic (2.29e-1)" "unprognostic (3.22e-1)" "unprognostic (1.65e-1)" "unprognostic (4.04e-2)" "prognostic unfavorable (4.27e-4)" "unprognostic (6.65e-2)" "unprognostic (1.67e-1)" "unprognostic (4.04e-2)" "unprognostic (5.15e-3)" 24.9 28.1 22.3 19.3 22.0 14.9 25.4 33.7 24.9 29.5 20.9 30.5 15.2 27.6 30.2 25.0 30.2 18.8 23.0 23.5 22.3 18.3 27.6 33.5 23.1 20.5 20.3 33.2 28.5 18.0 26.5 24.0 21.1 25.6 20.9 33.9 28.3 20.4 23.9 32.8 25.6 23.2 18.6 26.1 23.9 17.8 22.2 25.5 30.5 21.5 26.7 26.5 28.1 24.2 25.3 28.6 57.8 27.0 36.5 33.6 138.5 24.9 30.2 31.6 35.4 29.1 30.2 53.5 14.3 33.4 29.8 20.0 50.6 29.8 35.5 38.4 27.6 50.6 56.4 29.8 36.7 42.0 31.9 35.0 52.2 49.3 55.1 37.3 35.7 35.6 50.0 40.0 32.6 36.4 35.7 38.1 42.2 19.5 23.9 37.7 47.6 26.2 29.6 37.7 22.3 34.6 34.2 29.8 22.6 52.6 39.7 30.8 41.6 35.3 41.6 21.0 28.9 27.4 34.2 83.6 26.9 30.4 33.2 0.4 0.4 0.2 0.9 0.2 0.8 0.7 0.6 0.7 0.3 0.7 0.5 0.5 1.1 1.1 0.2 0.8 0.1 0.1 22.3 22.0 33.7 24.9 23.5 22.3 20.5 20.3 21.1 18.6 22.2 24.2 51.5 41.7 50.6 136.1 53.6 93.9 54.4 28.5 86.6 110.6 45.1 26.2 25.5 41.5 50.0 42.3 114.7 38.9 50.4 39.1 3.9 37.3 7.9 45.9 60.3 62.5 62.4 34.3 175.0 34.0 41.3 62.2 45.9 49.4 48.1 60.6 63.1 50.1 24.4 55.5 188.5 51.9 26.4 32.4 70.7 11.7 66.8 30.8 44.4 108.7 39.7 33.4 39.1 263.9 131.7 44.2 46.2 53.8 67.7 88.2 39.4 12.8 52.9 60.9 13.1 65.3 52.8 50.6 37.8 75.2 91.5 57.3 49.6 56.2 47.8 84.2 SGK1 SGK ENSG00000118515 "Serum/glucocorticoid regulated kinase 1" O00141 6 134169246-134318112 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 1007.1" "Cell type enhanced" "Detected in many" "Langerhans cells: 1238.4;Proximal enterocytes: 789.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "classical monocyte: 43.4;eosinophil: 170.2;neutrophil: 91.6" "Group enriched" "Detected in all" 8 "granulocytes: 170.2;monocytes: 43.4" "Cell line enhanced" "Detected in many" "HHSteC: 298.1;RPTEC TERT1: 469.5;SK-MEL-30: 319.7;TIME: 373.9;U-266/84: 358.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022085, CAB025148, HPA051251" Approved Enhanced "Nuclear speckles" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 41: Macrophages - Immune response" "Nuclear speckles" "CAB022085: , CAB025148: , HPA051251: AB_2681407" "unprognostic (2.05e-2)" "prognostic favorable (5.26e-4)" "unprognostic (1.12e-1)" "unprognostic (5.09e-3)" "unprognostic (2.76e-1)" "unprognostic (4.20e-2)" "unprognostic (4.53e-2)" "unprognostic (5.62e-2)" "unprognostic (4.03e-1)" "unprognostic (7.94e-2)" "unprognostic (1.78e-1)" "unprognostic (2.55e-1)" "unprognostic (5.82e-3)" "unprognostic (9.10e-2)" "unprognostic (3.81e-2)" "unprognostic (1.79e-1)" "unprognostic (6.59e-2)" 147.5 121.5 35.8 47.4 57.3 68.9 83.2 40.0 51.4 61.1 96.9 68.4 51.4 37.0 9.5 108.4 36.5 170.0 35.8 41.2 42.7 105.2 99.3 81.8 33.6 64.5 44.9 125.8 177.1 1007.1 12.0 70.6 49.6 47.6 39.0 14.1 70.8 60.3 50.2 75.7 282.5 48.4 35.8 21.5 104.2 30.4 53.6 39.7 56.7 33.9 78.1 141.3 96.7 94.0 4.1 6.9 4.2 0.4 51.7 12.9 5.9 76.7 159.4 98.4 79.8 12.2 10.6 13.1 11.3 79.8 48.0 2.5 6.8 12.2 72.0 0.5 3.1 0.6 175.7 9.2 298.1 0.7 6.8 77.3 75.4 96.7 124.3 39.3 167.1 2.3 25.6 192.8 35.6 0.6 1.1 3.0 4.8 20.3 8.3 2.4 8.9 1.5 469.5 1.4 2.2 18.6 241.7 0.7 319.7 43.2 0.5 2.1 373.9 28.8 12.3 176.9 17.1 36.2 358.5 40.3 26.7 12.0 39.5 2.2 43.4 170.2 0.7 24.4 1.6 1.9 1.3 0.8 14.1 1.4 1.6 2.0 91.6 3.6 14.5 0.9 2.5 12.6 35.8 57.3 40.0 51.4 41.2 42.7 64.5 44.9 49.6 35.8 53.6 94.0 346.2 38.5 177.8 34.0 68.0 183.3 133.7 277.3 329.0 12.0 87.1 112.0 28.4 88.6 168.6 68.0 35.5 41.0 27.0 132.2 21.5 81.3 9.6 145.8 73.1 232.1 10.7 14.7 68.2 171.2 33.6 88.8 206.4 483.4 271.8 33.9 353.4 21.9 284.2 0.0 225.7 65.1 91.6 181.3 1238.4 7.7 15.2 492.5 268.6 58.1 29.6 4.6 2.1 270.9 377.7 36.2 123.9 15.8 92.4 51.0 789.1 124.3 61.5 29.3 13.1 43.5 102.9 38.1 10.2 348.1 116.2 579.8 46.9 48.9 36.3 123.8 SGK2 ENSG00000101049 "Serum/glucocorticoid regulated kinase 2" Q9HBY8 20 43558968-43588237 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 40.5;kidney: 53.6;liver: 63.2" "Cell type enhanced" "Detected in many" "Distal enterocytes: 76.5;Distal tubular cells: 76.3;Hepatocytes: 32.8;Paneth cells: 21.7;Proximal enterocytes: 23.8;Proximal tubular cells: 25.5" "Cancer enhanced" "Detected in many" "liver cancer: 8.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 20.5;CAPAN-2: 14.2;Hep G2: 18.7;OE19: 61.7;RPTEC TERT1: 25.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA008859, HPA011387" Uncertain Supported Nucleoplasm NA NA "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "HPA008859: AB_2668159, HPA011387: AB_1856744" "unprognostic (1.82e-1)" "unprognostic (1.84e-1)" "unprognostic (4.53e-2)" "unprognostic (2.86e-1)" "unprognostic (6.27e-2)" "unprognostic (2.98e-4)" "unprognostic (2.05e-2)" "unprognostic (1.35e-1)" "unprognostic (4.30e-2)" "unprognostic (2.60e-1)" "unprognostic (1.05e-1)" "unprognostic (5.72e-4)" "unprognostic (4.15e-2)" "unprognostic (1.38e-1)" "unprognostic (2.56e-1)" "unprognostic (3.11e-2)" "prognostic favorable (5.65e-4)" 23.5 1.4 4.9 1.5 14.8 0.5 6.1 12.6 10.5 3.5 0.7 37.7 31.6 1.8 33.8 1.0 3.7 10.0 1.2 6.0 7.7 53.6 63.2 1.0 0.2 18.1 13.3 6.6 16.2 0.5 3.0 0.8 14.3 2.6 40.5 5.6 1.8 2.9 0.4 6.2 20.1 1.6 11.8 1.1 22.8 1.8 13.3 0.3 1.7 0.4 0.3 4.2 3.0 24.5 0.0 20.5 0.3 0.1 0.3 0.0 0.1 0.2 0.0 0.2 0.0 0.6 14.2 0.1 8.7 0.1 0.1 0.2 0.0 0.0 0.2 0.0 0.3 0.4 0.0 18.7 0.4 0.0 0.1 0.0 0.5 0.0 0.0 0.7 0.0 0.4 0.2 0.1 0.0 0.1 0.1 0.5 0.1 61.7 0.0 0.1 0.1 0.0 25.4 4.2 0.2 1.0 0.0 1.2 0.1 0.4 0.0 0.1 0.9 0.0 0.1 0.0 0.0 0.9 0.0 0.0 0.2 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.9 14.8 12.6 10.5 6.0 7.7 18.1 13.3 14.3 11.8 13.3 24.5 0.3 0.0 0.0 4.9 0.2 0.1 0.1 0.2 0.0 0.8 0.3 0.8 4.9 8.6 0.0 11.0 0.0 5.1 0.0 76.5 76.3 6.8 0.3 0.9 0.5 0.6 1.8 0.0 0.7 6.3 1.3 0.4 11.2 2.4 0.0 0.7 0.7 32.8 0.7 6.7 1.3 4.1 0.0 1.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.2 0.0 3.5 20.7 2.5 21.7 0.4 0.0 0.1 23.8 25.5 0.2 0.8 0.0 0.2 0.4 0.1 0.1 0.0 0.1 17.1 0.2 0.0 7.7 0.3 SGK3 "SGK2, SGKL" ENSG00000104205 "Serum/glucocorticoid regulated kinase family member 3" Q96BR1 8 66712734-66862022 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 49.0" "Cell type enhanced" "Detected in many" "Breast glandular cells: 56.0;monocytes: 53.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "T-47d: 28.4" "HPA006699, HPA027146" Supported Approved Nucleoplasm,Vesicles NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 6: T47d - Mammary gland" "Cluster 35: Glandular cells - Unknown function" Vesicles Nucleoplasm "HPA006699: , HPA027146: AB_1856745" "prognostic favorable (5.52e-6)" "prognostic favorable (8.28e-4)" "unprognostic (8.52e-3)" "unprognostic (1.10e-2)" "unprognostic (3.75e-1)" "unprognostic (1.37e-2)" "unprognostic (2.32e-1)" "unprognostic (1.69e-3)" "unprognostic (9.51e-2)" "unprognostic (8.86e-3)" "prognostic favorable (9.65e-4)" "unprognostic (1.94e-2)" "unprognostic (8.95e-2)" "unprognostic (4.55e-3)" "unprognostic (1.77e-1)" "unprognostic (1.01e-1)" "unprognostic (5.29e-3)" 5.2 5.3 13.4 9.8 25.7 8.5 24.1 21.3 16.9 10.5 36.0 10.3 8.9 8.0 8.6 7.6 6.9 7.5 5.4 14.6 17.3 14.7 13.6 10.0 7.8 29.4 21.6 9.1 15.6 28.3 6.2 5.7 28.3 7.4 10.3 2.4 7.0 7.1 2.9 13.3 11.3 5.3 19.3 8.9 7.5 9.4 20.9 5.8 17.5 3.5 6.9 5.0 5.7 49.0 14.2 3.7 0.6 2.4 3.9 6.5 7.7 8.1 7.4 4.2 5.1 6.1 8.6 10.2 2.2 7.7 13.6 4.9 7.3 5.5 5.4 5.3 11.7 9.7 2.6 6.7 4.1 8.9 10.5 2.9 3.7 1.7 7.9 4.3 7.4 7.4 1.5 4.6 10.0 2.4 6.2 5.8 1.9 8.5 5.0 11.7 5.3 7.6 6.4 3.3 2.9 2.2 3.4 6.5 14.4 6.0 28.4 16.9 9.0 4.4 3.9 3.9 3.4 6.1 12.8 12.7 4.5 14.2 4.9 21.1 15.0 5.1 8.7 9.9 13.8 4.7 8.8 8.0 13.8 6.4 8.7 7.1 2.0 7.2 5.1 8.9 5.7 9.0 13.4 25.7 21.3 16.9 14.6 17.3 29.4 21.6 28.3 19.3 20.9 49.0 20.7 6.4 28.1 0.0 12.5 13.3 8.1 3.3 8.6 1.7 56.0 30.5 7.6 7.2 8.5 11.0 18.8 9.2 24.9 13.3 15.6 7.0 0.9 16.7 6.6 15.3 16.2 10.3 0.0 18.2 1.4 8.9 6.6 12.3 15.2 11.0 17.5 20.7 22.9 0.0 0.0 9.3 8.2 41.9 14.3 2.2 4.1 42.6 8.8 0.0 53.4 3.8 19.6 0.0 0.0 14.8 8.4 7.9 18.3 9.3 14.0 36.8 15.4 1.7 0.0 5.9 4.2 5.9 13.7 9.9 15.8 4.8 19.4 5.2 10.4 5.3 SH3RF1 "KIAA1494, POSH, RNF142, SH3MD2" ENSG00000154447 "SH3 domain containing ring finger 1" Q7Z6J0 4 169094259-169270956 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 146.3;Oligodendrocytes: 213.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "intermediate monocyte: 4.2;myeloid DC: 2.5;non-classical monocyte: 6.7" "Group enriched" "Detected in many" 15 "dendritic cells: 2.5;monocytes: 6.7" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA074783 Approved Supported "Vesicles,Intermediate filaments" No No "Cluster 51: Monocytes - Innate immune response" "Cluster 45: Intestine - Brush border" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 22: Epithelial cell types - Mixed function" Vesicles "Intermediate filaments" "HPA074783: AB_2732268" "unprognostic (4.14e-1)" "unprognostic (4.67e-2)" "unprognostic (1.23e-1)" "unprognostic (7.83e-2)" "unprognostic (1.02e-1)" "unprognostic (1.30e-2)" "unprognostic (1.29e-1)" "unprognostic (2.65e-1)" "unprognostic (8.44e-2)" "unprognostic (9.58e-2)" "unprognostic (4.77e-3)" "unprognostic (7.88e-2)" "prognostic favorable (5.51e-8)" "unprognostic (4.43e-2)" "unprognostic (1.63e-1)" "unprognostic (5.99e-2)" "unprognostic (1.77e-1)" 9.8 3.7 8.7 4.4 10.0 3.4 8.2 7.6 13.1 5.7 5.9 15.1 13.8 4.3 5.7 5.9 5.6 11.9 5.7 18.2 8.6 12.2 8.0 9.4 3.3 8.8 9.7 8.5 10.4 3.7 3.7 7.4 9.4 14.3 13.6 2.4 15.8 8.4 9.4 5.1 13.1 4.0 8.2 3.9 24.7 6.1 9.5 2.0 19.9 10.0 3.2 9.3 4.4 13.0 15.2 12.2 11.0 31.9 11.5 14.3 14.1 40.5 19.7 30.0 13.8 12.5 17.8 0.0 1.9 43.1 8.1 9.8 8.9 16.2 32.4 0.1 5.2 8.7 27.4 6.5 26.0 3.1 0.3 8.5 8.6 25.7 19.9 37.3 18.7 3.3 0.1 0.0 27.8 6.0 3.1 2.9 5.6 19.2 10.5 4.5 3.6 0.6 13.6 11.8 8.3 9.9 10.4 15.7 4.2 4.7 5.2 1.3 17.1 14.2 11.0 23.6 14.7 1.1 0.0 0.1 16.0 3.0 17.3 0.0 1.0 0.0 0.0 4.2 0.0 0.3 0.0 0.0 2.5 0.1 0.0 0.0 0.0 0.2 6.7 0.2 0.0 0.6 8.7 10.0 7.6 13.1 18.2 8.6 8.8 9.7 9.4 8.2 9.5 13.0 28.0 64.1 37.7 146.3 3.4 34.3 48.3 11.9 13.6 3.5 21.1 15.6 11.2 44.3 34.4 27.6 0.0 12.7 0.4 69.3 11.7 42.2 5.5 28.5 14.2 13.0 31.3 2.1 54.9 63.7 22.1 16.5 65.7 46.5 10.2 5.6 11.4 12.4 7.4 0.0 54.9 27.1 12.2 9.3 5.3 3.5 12.2 11.1 3.6 52.5 3.9 11.3 0.0 89.5 213.0 68.4 37.2 12.0 2.4 63.2 28.9 18.4 31.7 1.2 65.7 24.1 36.9 5.4 10.7 9.4 12.6 13.1 1.7 6.5 34.4 72.0 SH3RF2 "FLJ23654, Hepp1, POSHER, PPP1R39, RNF158" ENSG00000156463 "SH3 domain containing ring finger 2" Q8TEC5 5 145936578-146081791 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Protein phosphatase inhibitor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 58.1;skeletal muscle: 42.4;skin 1: 56.8" "Cell type enriched" "Detected in many" 5 "Late spermatids: 7869.1" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in some" 4 "basal ganglia: 6.1;cerebral cortex: 4.1;thalamus: 1.7" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CACO-2: 70.3;GAMG: 29.8;hTERT-RPE1: 33.5" "Region enriched" "Detected in many" 14 "basal ganglia: 26.7" "Region enhanced" "Detected in many" "basal ganglia: 9.7" "HPA035903, HPA058119" Uncertain Enhanced Nucleoplasm NA Yes "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 31: Skin - Epidermis development" "Cluster 39: CACO-2 - Unknown function" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "HPA035903: AB_10696515, HPA058119: AB_2683611" "unprognostic (8.90e-3)" "unprognostic (2.00e-3)" "unprognostic (5.11e-3)" "unprognostic (1.66e-2)" "unprognostic (1.45e-3)" "unprognostic (1.47e-2)" "unprognostic (9.96e-3)" "unprognostic (8.22e-2)" "unprognostic (3.92e-1)" "unprognostic (7.37e-3)" "unprognostic (2.44e-3)" "unprognostic (1.66e-1)" "unprognostic (2.98e-2)" "unprognostic (5.21e-2)" "unprognostic (1.46e-1)" "unprognostic (2.64e-2)" "unprognostic (4.13e-3)" 1.9 0.9 0.6 2.5 6.1 0.0 4.7 0.0 4.1 7.6 0.2 14.3 16.0 1.1 3.6 34.1 6.1 11.9 58.1 0.9 0.5 0.9 7.0 2.7 0.2 0.0 0.3 0.4 15.4 0.0 1.6 0.1 0.0 2.7 14.3 0.5 12.1 0.6 42.4 56.8 13.7 1.1 0.0 0.0 20.5 6.8 1.7 1.0 6.3 8.8 7.7 1.2 20.6 0.4 21.0 5.7 0.2 1.1 0.0 0.0 0.0 0.2 1.7 4.1 1.7 70.3 19.0 0.0 10.5 0.9 29.8 18.9 0.0 22.4 4.0 0.3 0.3 0.0 8.5 9.5 1.2 0.0 0.0 0.2 11.9 6.4 14.8 33.5 0.2 0.5 0.0 0.0 1.8 0.1 0.0 0.0 1.6 17.3 1.5 0.0 0.2 0.0 8.7 2.0 0.0 0.0 1.2 0.4 0.5 1.0 6.6 0.1 9.8 0.8 17.3 1.5 6.7 0.0 0.0 0.0 10.6 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.1 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.6 6.1 0.0 4.1 0.9 0.5 0.0 0.3 0.0 0.0 1.7 0.4 4.1 16.0 2.3 1.6 0.0 55.1 5.4 14.5 38.7 0.4 3.9 3.3 510.0 8.6 6.7 1.8 0.0 0.2 0.2 38.9 0.0 5.7 1511.3 11.9 0.9 9.7 1.2 0.0 10.5 8.7 0.0 15.4 50.4 26.7 1.3 0.1 0.7 8.4 0.2 0.0 2.2 16.1 8.2 0.0 4.9 7869.1 25.7 2.6 8.8 10.3 0.6 1.6 0.0 1.5 0.7 21.4 22.9 34.6 0.6 2.2 26.6 0.9 4.4 0.1 13.1 1.6 6.3 31.4 20.7 70.9 50.0 0.0 0.7 2.9 33.2 6.6 SH3RF3 "FLJ00204, POSH2, SH3MD4" ENSG00000172985 "SH3 domain containing ring finger 3" Q8TEJ3 2 109129205-109504634 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in many" 7 "Astrocytes: 47.0;Excitatory neurons: 108.3;Inhibitory neurons: 160.9;Microglial cells: 164.9;Oligodendrocyte precursor cells: 42.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HHSteC: 19.8;RPMI-8226: 20.5;TIME: 23.2;U-266/84: 28.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA044822, HPA048444" Approved Supported Nucleoplasm Yes No "Cluster 47: Non-specific - Unknown function" "Cluster 16: U-266 - Nucleosome" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA044822: AB_2679103, HPA048444: AB_2680396" "unprognostic (1.97e-1)" "unprognostic (8.84e-3)" "unprognostic (8.04e-2)" "unprognostic (1.91e-1)" "unprognostic (2.55e-1)" "unprognostic (1.78e-1)" "unprognostic (8.00e-2)" "unprognostic (1.76e-1)" "unprognostic (2.98e-2)" "prognostic unfavorable (2.33e-4)" "unprognostic (4.57e-2)" "unprognostic (1.95e-1)" "unprognostic (3.54e-2)" "unprognostic (4.94e-2)" "unprognostic (2.72e-1)" "unprognostic (2.79e-2)" "unprognostic (1.39e-2)" 6.1 6.7 4.7 3.0 6.1 0.8 4.3 1.3 6.5 5.5 1.6 5.6 1.1 3.7 0.7 2.8 4.8 4.4 6.0 6.3 3.2 6.8 1.1 7.2 2.1 3.0 4.5 3.2 2.0 0.5 1.9 5.2 2.8 4.7 1.4 0.6 1.6 4.4 5.7 3.1 3.3 3.8 3.1 2.1 2.9 4.2 3.9 3.2 2.5 7.3 1.2 5.5 4.2 3.5 0.0 0.1 0.1 2.2 9.0 6.9 0.0 4.2 12.2 3.1 1.1 1.1 0.0 0.0 3.1 3.1 0.7 0.0 0.2 1.8 1.3 0.0 4.2 0.0 0.2 0.0 19.8 0.1 0.0 12.0 2.9 14.1 6.3 1.8 11.4 2.2 0.0 11.7 7.3 0.0 0.0 6.5 1.1 0.0 12.0 2.6 0.0 20.5 0.0 0.0 0.7 2.5 0.0 0.0 0.4 0.1 0.2 0.0 23.2 4.0 12.0 11.5 5.5 4.0 28.6 0.0 0.0 6.3 5.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 4.7 6.1 1.3 6.5 6.3 3.2 3.0 4.5 2.8 3.1 3.9 3.5 5.3 0.0 0.0 47.0 0.2 1.9 0.4 0.2 1.8 0.5 0.6 0.5 10.7 0.0 0.7 0.0 0.0 0.0 1.5 0.1 0.0 1.1 2.6 9.4 9.6 6.7 1.8 0.0 108.3 0.2 0.2 4.8 0.0 1.1 0.0 0.2 7.5 0.0 4.7 10.1 160.9 0.8 0.0 2.5 1.5 5.2 2.1 1.2 5.4 164.9 0.0 1.7 0.0 42.3 1.9 0.1 0.0 3.0 1.6 0.2 0.0 0.6 2.1 0.0 13.1 3.2 6.8 0.7 9.6 0.8 0.9 0.1 0.5 2.3 0.1 0.0 SHPRH "bA545I5.2, FLJ90837, KIAA2023" ENSG00000146414 "SNF2 histone linker PHD RING helicase" Q149N8 6 145864245-145964423 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Helicase, Hydrolase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 210.6;Oligodendrocytes: 164.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034854, HPA044852" Approved Approved "Nucleoplasm,Nuclear membrane,Cytosol" NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 34: Non-specific - Transcription" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Nuclear membrane" Cytosol "HPA034854: AB_10964488, HPA044852: " "unprognostic (3.10e-2)" "unprognostic (4.46e-2)" "unprognostic (5.61e-3)" "unprognostic (1.53e-2)" "unprognostic (7.40e-3)" "unprognostic (2.20e-2)" "unprognostic (2.63e-1)" "unprognostic (1.83e-1)" "unprognostic (1.36e-1)" "unprognostic (8.66e-3)" "unprognostic (5.03e-1)" "unprognostic (7.90e-2)" "unprognostic (6.01e-3)" "unprognostic (3.29e-2)" "unprognostic (2.70e-1)" "unprognostic (1.13e-1)" "unprognostic (3.01e-1)" 4.9 4.2 3.1 4.7 3.7 4.2 7.2 18.4 5.1 5.4 3.2 4.3 4.2 7.7 6.0 4.3 5.2 4.6 3.5 3.0 2.5 5.5 4.6 4.2 6.9 2.8 2.6 12.2 3.9 6.7 2.0 4.5 4.5 5.5 5.0 16.3 5.8 5.1 4.2 9.7 4.5 5.7 2.5 6.4 5.4 7.6 2.9 7.2 8.4 5.2 5.8 4.3 3.3 5.5 4.2 3.2 15.3 9.1 7.0 7.3 7.2 4.9 3.9 5.9 7.6 7.0 2.9 14.5 5.9 3.7 4.6 7.0 9.5 6.9 7.7 6.5 10.9 14.6 7.6 6.1 5.2 31.2 8.6 5.2 7.8 5.6 8.0 5.8 6.4 10.0 20.3 7.9 5.1 3.7 19.8 11.6 10.3 6.9 5.4 14.1 23.6 5.0 8.0 4.1 12.6 8.8 8.7 7.9 5.4 10.5 4.2 14.6 7.2 3.7 7.0 7.4 5.8 6.4 9.4 17.1 3.9 13.0 6.0 0.7 0.9 1.9 1.7 0.9 1.5 1.5 1.4 1.1 1.1 2.5 1.5 1.3 0.0 1.5 1.0 2.0 1.4 0.5 3.1 3.7 18.4 5.1 3.0 2.5 2.8 2.6 4.5 2.5 2.9 5.5 31.4 28.9 23.4 106.7 31.0 21.2 17.9 14.5 19.4 117.2 21.5 20.3 17.2 20.0 20.7 22.0 210.6 16.1 34.6 9.1 7.9 18.6 20.4 20.9 52.8 26.0 19.2 15.3 131.0 12.9 7.0 25.9 23.9 18.1 13.3 145.7 15.7 20.5 12.0 94.2 140.3 14.7 6.1 21.4 9.8 8.0 50.7 19.8 14.2 93.7 30.6 40.7 36.0 143.7 164.6 15.9 8.8 34.3 23.5 18.8 17.2 7.5 14.9 158.5 72.3 47.1 39.1 83.2 65.0 16.5 19.7 6.6 26.4 61.5 18.0 12.5 SI ENSG00000090402 Sucrase-isomaltase P14410 3 164978898-165078496 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Glycosidase, Hydrolase, Multifunctional enzyme" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 150 "intestine: 545.1" "Cell type enriched" "Detected in some" 8 "Proximal enterocytes: 1083.9" "Cancer enhanced" "Detected in some" "stomach cancer: 6.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 1.1;CACO-2: 1.5;HeLa: 1.2;NB-4: 1.3;RPMI-8226: 2.0;SH-SY5Y: 1.1" "Not detected" "Not detected" "Not detected" "Not detected" HPA011897 Enhanced NA NA "Cluster 56: Intestine - Transmembrane transport" "Cluster 24: NB-4 - Immune response" "Cluster 45: Enterocytes - Digestion" "HPA011897: AB_1856840" "unprognostic (2.71e-2)" "unprognostic (1.62e-2)" "unprognostic (2.68e-1)" "unprognostic (2.05e-1)" "unprognostic (4.41e-2)" 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.6 545.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 31.0 0.0 0.0 0.0 0.0 0.0 448.2 0.8 0.0 0.0 0.6 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.2 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 37.1 0.0 0.0 9.7 0.0 0.0 0.1 5.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 123.0 0.0 0.0 0.0 5.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 124.7 0.0 0.0 0.3 1083.9 0.1 0.0 0.0 0.0 0.0 0.0 0.9 0.3 0.0 0.0 0.0 0.0 0.0 77.8 0.0 SIAE "CSE-C, LSE, MGC87009, YSG2" ENSG00000110013 "Sialic acid acetylesterase" Q9HAT2 11 124633113-124695707 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Serine esterase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 104.4" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 58.0;Cardiomyocytes: 59.5;Distal enterocytes: 102.4;Paneth cells: 53.0;Proximal enterocytes: 51.6;Undifferentiated cells: 63.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 7.6" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "ASC diff: 88.6;ASC TERT1: 91.3;HSkMC: 98.9;OE19: 97.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038052, HPA038053" Approved "Intracellular and membrane" NA NA 2200000 "Cluster 18: Basophils - Vesicular transport" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA038052: AB_10671518, HPA038053: AB_10673039" "unprognostic (9.97e-2)" "unprognostic (1.28e-2)" "unprognostic (2.48e-3)" "prognostic favorable (4.66e-5)" "unprognostic (3.30e-2)" "unprognostic (5.20e-2)" "unprognostic (4.90e-2)" "unprognostic (4.32e-2)" "unprognostic (1.18e-1)" "unprognostic (2.26e-1)" "unprognostic (2.45e-1)" "unprognostic (9.19e-2)" "prognostic favorable (4.42e-11)" "unprognostic (7.24e-2)" "unprognostic (3.22e-1)" "unprognostic (4.49e-2)" "unprognostic (1.92e-2)" 18.7 17.3 16.8 11.8 21.6 3.7 15.9 26.9 19.8 13.0 38.9 97.8 34.3 7.1 34.3 13.6 19.3 16.7 43.8 16.1 27.1 62.1 43.4 20.6 5.8 25.3 23.7 5.7 17.3 45.3 14.4 11.8 24.7 20.4 104.4 6.2 18.4 15.3 26.7 13.0 35.8 10.4 23.0 9.1 19.0 10.3 24.9 3.7 54.0 33.3 6.7 16.8 7.8 26.3 8.9 14.0 8.0 34.6 88.6 91.3 20.9 16.8 24.0 4.3 2.6 10.9 61.4 5.5 24.2 21.5 9.4 17.3 12.8 18.7 4.2 26.0 3.9 8.6 3.7 11.1 41.8 0.7 7.2 98.9 24.9 11.4 17.3 58.5 30.6 11.0 7.1 37.5 14.8 16.5 0.2 0.6 5.0 97.7 28.5 3.2 0.2 8.4 51.4 12.1 2.4 5.1 46.5 18.6 8.0 24.0 36.8 3.2 34.1 23.6 4.3 26.5 4.0 9.4 7.5 0.7 8.3 4.6 9.8 7.6 2.9 0.1 0.4 2.1 0.3 0.5 1.3 0.6 1.9 0.7 1.7 1.1 0.5 0.2 3.7 0.5 0.6 1.8 16.8 21.6 26.9 19.8 16.1 27.1 25.3 23.7 24.7 23.0 24.9 26.3 4.2 19.2 58.0 11.8 2.4 3.2 6.3 6.7 7.4 6.5 10.1 4.3 59.5 12.8 9.4 36.8 0.0 7.6 0.6 102.4 9.8 15.2 14.0 9.1 9.3 6.9 14.5 5.2 15.0 3.8 8.8 7.5 12.8 14.0 1.3 3.9 8.9 30.0 4.5 5.0 9.1 31.0 4.1 3.5 1.6 12.0 3.1 4.3 3.6 6.5 4.5 1.9 1.0 8.0 6.7 5.2 53.0 1.2 3.9 7.4 51.6 26.2 11.9 1.8 0.0 4.9 7.9 14.8 9.6 12.2 5.3 6.7 2.0 8.9 63.6 7.1 SIAH1 hSIAH1 ENSG00000196470 "Siah E3 ubiquitin protein ligase 1" Q8IUQ4 16 48356364-48448402 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters" "Apoptosis, Cell cycle, Differentiation, Spermatogenesis, Ubl conjugation pathway" "Developmental protein, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Cytotrophoblasts: 187.4;Syncytiotrophoblasts: 746.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB018724 Enhanced Uncertain Nucleoplasm,Mitochondria NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 28: Placenta - Pregnancy" "Cluster 30: Epithelial cell lines - Translation" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Mitochondria Nucleoplasm "CAB018724: AB_2188865" "unprognostic (7.08e-2)" "unprognostic (1.16e-1)" "unprognostic (4.88e-2)" "unprognostic (1.07e-1)" "unprognostic (2.92e-3)" "unprognostic (1.25e-2)" "unprognostic (7.93e-3)" "unprognostic (1.12e-2)" "unprognostic (9.22e-3)" "unprognostic (3.26e-1)" "unprognostic (8.02e-2)" "unprognostic (7.84e-3)" "unprognostic (7.67e-3)" "unprognostic (4.38e-2)" "unprognostic (4.00e-1)" "unprognostic (9.55e-2)" "unprognostic (1.26e-2)" 23.3 14.1 12.0 10.8 13.9 28.2 22.8 16.2 16.0 19.3 13.3 15.9 16.0 19.4 15.6 14.0 17.4 15.8 15.0 12.3 12.4 14.6 22.6 17.6 14.0 13.6 14.6 19.2 14.1 14.6 10.3 50.1 13.2 16.8 14.6 19.1 16.1 13.8 21.5 22.3 16.2 14.5 12.2 13.4 15.7 23.3 13.5 14.1 17.5 17.3 13.0 14.1 17.1 16.9 15.5 13.7 29.1 26.3 24.5 21.3 29.6 14.2 19.2 20.6 10.1 10.5 19.7 20.1 15.3 18.0 14.4 17.6 20.3 20.7 25.3 8.1 16.4 10.8 10.6 27.8 34.2 10.7 15.8 25.8 36.5 12.1 27.9 23.1 17.5 18.5 17.7 18.4 17.0 10.6 29.1 21.9 35.5 17.1 21.0 33.3 43.7 21.3 19.5 19.3 33.1 29.3 42.0 20.9 37.7 24.8 13.3 24.4 18.8 22.0 19.8 12.0 15.4 24.0 10.7 36.8 16.3 13.1 20.2 13.7 8.1 35.4 4.1 3.6 4.5 20.4 4.4 6.3 13.0 19.2 8.7 6.6 4.7 8.7 2.2 12.5 2.5 5.8 12.0 13.9 16.2 16.0 12.3 12.4 13.6 14.6 13.2 12.2 13.5 16.9 43.0 12.8 9.7 8.8 24.7 85.7 55.7 45.0 71.2 22.3 43.5 32.0 13.3 20.0 20.5 16.5 8.4 187.4 15.3 27.3 31.3 24.5 70.5 21.9 26.7 35.7 22.6 27.0 20.1 22.7 34.0 42.5 21.9 34.5 4.5 37.8 33.9 23.6 34.3 35.3 20.9 17.8 40.7 20.3 99.2 71.3 22.7 31.1 49.8 23.4 27.0 38.3 4.1 25.6 40.2 22.3 18.2 19.5 17.9 49.7 23.5 28.9 17.0 18.6 19.7 36.2 34.4 70.0 51.0 67.7 75.7 746.2 17.3 17.4 20.6 50.8 SIAH2 ENSG00000181788 "Siah E3 ubiquitin protein ligase 2" O43255 3 150741125-150763477 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters" "Apoptosis, Biological rhythms, Cell cycle, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Erythroid cells: 226.7;Syncytiotrophoblasts: 389.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA061293, CAB069930" Approved Approved Nucleoplasm,Vesicles NA NA "Cluster 46: Basophils - DNA binding" "Cluster 85: Liver - Metabolism" "Cluster 29: U-266 - Adaptive immune response" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Nucleoplasm Vesicles "CAB069930: AB_1217916, HPA061293: AB_2684470" "prognostic favorable (1.17e-4)" "unprognostic (1.04e-3)" "unprognostic (3.83e-2)" "unprognostic (9.15e-2)" "unprognostic (1.69e-1)" "unprognostic (6.91e-2)" "unprognostic (1.86e-2)" "unprognostic (5.68e-3)" "unprognostic (6.26e-2)" "unprognostic (1.95e-2)" "prognostic unfavorable (8.21e-5)" "unprognostic (1.34e-1)" "unprognostic (1.38e-1)" "unprognostic (2.38e-2)" "unprognostic (5.56e-1)" "unprognostic (1.66e-1)" "unprognostic (4.69e-2)" 15.8 78.6 16.4 20.8 19.0 44.7 17.1 17.4 24.9 48.0 17.3 17.7 13.5 33.4 18.6 46.1 27.2 14.3 16.2 16.9 16.7 12.1 61.2 13.2 35.8 15.8 15.5 24.4 20.9 15.9 11.0 43.1 17.9 19.4 15.4 7.8 16.4 34.7 12.3 30.4 12.9 29.4 15.5 24.4 17.9 8.0 16.5 25.1 8.0 12.8 45.3 23.5 39.6 26.0 54.0 13.4 10.5 20.1 35.4 26.4 41.7 22.9 26.5 27.3 32.4 28.4 24.7 31.3 31.0 24.1 22.8 31.4 28.6 20.7 25.6 24.4 19.5 61.5 16.0 94.7 50.4 34.3 16.0 24.1 47.0 16.3 36.9 21.7 21.5 60.2 15.5 110.8 17.4 66.4 58.7 17.4 33.1 52.3 26.0 44.0 22.7 110.4 17.4 17.9 38.4 19.1 17.4 15.4 39.8 23.8 99.5 50.0 15.0 17.7 15.8 40.1 31.0 130.6 55.9 42.0 17.6 48.6 9.2 8.9 2.2 8.6 1.6 1.2 2.5 2.2 2.8 2.5 2.0 2.2 1.4 1.4 4.7 1.4 1.3 2.6 1.6 0.9 16.4 19.0 17.4 24.9 16.9 16.7 15.8 15.5 17.9 15.5 16.5 26.0 15.9 6.4 4.8 6.8 99.0 146.7 82.3 11.8 153.1 47.0 32.3 22.2 17.8 25.8 11.7 22.0 37.5 192.0 62.6 30.2 13.7 8.5 3.4 56.0 29.2 22.5 38.3 226.7 14.1 6.6 23.4 28.8 44.4 96.5 10.2 18.7 20.7 54.4 32.6 35.3 11.0 39.9 14.2 115.5 102.7 2.1 44.1 70.4 44.4 14.0 22.7 32.7 32.0 5.0 11.5 10.5 17.9 30.9 128.7 56.7 20.7 17.9 16.5 2.8 13.1 11.8 29.9 0.7 10.8 154.1 142.4 389.4 86.1 28.6 34.5 81.8 SIK2 "DKFZp434K1115, KIAA0781, LOH11CR1I, QIK, SNF1LK2" ENSG00000170145 "Salt inducible kinase 2" Q9H0K1 11 111602449-111730855 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 113.3;Excitatory neurons: 217.6;Inhibitory neurons: 132.4;Oligodendrocytes: 191.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "ASC diff: 50.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016026, HPA071049" Approved Approved "Nucleoplasm,Nuclear speckles,Vesicles,Intermediate filaments,Cytosol" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoplasm, Vesicles" "Nuclear speckles, Intermediate filaments, Cytosol" "HPA016026: AB_1857321, HPA071049: " "unprognostic (2.35e-1)" "unprognostic (1.10e-1)" "unprognostic (1.08e-1)" "unprognostic (1.10e-2)" "unprognostic (1.59e-2)" "unprognostic (4.81e-2)" "prognostic favorable (4.93e-4)" "unprognostic (6.41e-2)" "unprognostic (1.87e-1)" "unprognostic (1.40e-2)" "unprognostic (3.72e-3)" "unprognostic (9.27e-2)" "prognostic favorable (1.17e-9)" "unprognostic (1.23e-1)" "unprognostic (2.79e-1)" "unprognostic (2.82e-3)" "unprognostic (2.13e-2)" 29.7 9.3 9.2 5.3 12.4 3.1 20.7 7.9 11.1 7.6 11.0 7.9 5.9 7.3 5.0 5.9 8.1 10.0 12.3 9.5 14.7 11.4 22.7 11.7 4.4 11.9 11.9 14.9 31.8 21.3 16.6 5.8 10.6 6.7 6.2 30.7 13.8 6.2 33.1 8.9 7.5 5.9 5.5 4.6 17.6 3.0 9.3 5.4 8.7 23.2 4.3 7.7 6.1 11.6 9.2 6.0 10.3 11.1 50.3 14.8 6.1 7.9 11.2 5.9 6.7 20.5 9.6 7.2 10.7 9.2 6.9 12.7 8.2 5.9 7.6 5.4 3.4 7.9 5.2 10.1 10.9 7.7 4.9 14.5 8.6 8.7 11.1 11.7 7.1 7.1 7.4 10.3 9.4 4.3 8.0 7.0 3.5 7.6 5.9 10.6 11.0 8.7 13.1 8.2 4.8 11.3 11.6 4.7 4.5 9.4 11.5 6.2 9.9 12.9 7.7 8.3 10.9 2.9 2.4 14.8 4.2 10.6 8.8 0.3 0.7 0.6 0.7 0.7 0.3 0.4 0.5 0.5 0.6 0.4 0.2 0.4 0.3 0.5 0.6 0.3 0.5 0.5 9.2 12.4 7.9 11.1 9.5 14.7 11.9 11.9 10.6 5.5 9.3 11.6 22.1 19.2 24.8 113.3 14.1 14.7 6.2 5.2 18.2 15.7 10.5 9.9 21.3 27.1 10.0 16.5 66.7 4.4 11.4 15.6 5.9 10.4 16.5 27.7 14.9 18.8 18.0 12.4 217.6 7.9 4.6 20.1 27.5 45.3 9.5 24.3 9.3 38.7 5.4 32.0 132.4 11.3 4.1 12.4 16.9 14.1 11.5 13.3 19.6 73.1 6.0 14.5 4.1 86.0 191.9 8.4 10.3 14.7 8.9 6.9 8.3 23.1 13.4 60.9 0.0 19.1 19.0 3.9 6.4 10.3 11.9 5.2 12.6 5.0 11.5 7.1 SIK3 "FLJ12240, KIAA0999, L19, QSK" ENSG00000160584 "SIK family kinase 3" Q9Y2K2 11 116843402-117098437 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 375.5;Excitatory neurons: 384.4;Inhibitory neurons: 399.6;Oligodendrocyte precursor cells: 457.9;Oligodendrocytes: 1679.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045245, HPA048161" Enhanced Enhanced Nucleoplasm NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 36: HEL - Hemostasis" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA045245: AB_2679270, HPA048161: AB_2680293" "unprognostic (3.19e-2)" "unprognostic (3.31e-1)" "unprognostic (2.78e-2)" "unprognostic (8.21e-2)" "unprognostic (1.31e-1)" "unprognostic (2.30e-2)" "unprognostic (2.73e-1)" "unprognostic (2.33e-2)" "unprognostic (7.63e-2)" "unprognostic (2.46e-2)" "unprognostic (1.28e-3)" "unprognostic (1.89e-1)" "prognostic favorable (1.12e-5)" "unprognostic (1.82e-1)" "unprognostic (6.85e-2)" "unprognostic (1.02e-2)" "unprognostic (3.28e-2)" 10.1 7.2 19.3 11.4 36.6 12.7 9.2 15.0 34.3 9.6 0.0 11.7 8.5 12.6 7.2 10.4 12.4 9.8 12.8 19.7 19.4 10.3 13.8 9.7 9.9 22.0 23.1 16.5 15.4 17.7 10.0 12.1 22.5 8.2 8.8 19.1 9.8 11.3 19.5 7.5 8.7 14.1 11.5 11.8 9.7 21.4 36.1 12.3 17.1 14.4 10.4 10.1 7.5 41.1 11.8 8.9 13.9 14.7 11.7 12.6 22.2 8.8 15.7 6.8 7.6 21.8 13.3 13.9 14.0 16.3 15.0 18.1 11.6 12.7 9.4 38.5 7.4 31.2 9.7 13.6 10.9 11.2 11.8 13.9 7.2 14.5 23.3 8.7 9.2 9.0 15.2 10.1 9.4 4.0 10.2 12.1 7.7 8.0 6.6 12.9 8.0 11.1 9.3 2.2 13.5 10.8 23.7 10.3 4.4 10.5 6.8 11.8 10.6 8.3 10.4 14.0 8.9 7.1 5.6 17.5 7.7 18.2 11.4 2.0 0.4 0.0 0.3 0.5 0.5 0.1 0.3 0.1 0.6 1.0 0.0 0.0 0.9 0.6 1.5 0.0 0.0 0.2 19.3 36.6 15.0 34.3 19.7 19.4 22.0 23.1 22.5 11.5 36.1 41.1 25.8 9.6 22.1 375.5 34.9 26.5 26.0 6.8 7.4 42.6 26.1 21.5 22.2 10.0 12.4 5.5 112.6 8.7 47.3 12.5 5.9 7.6 89.2 64.4 27.9 20.4 17.3 12.4 384.4 7.3 2.8 22.1 12.8 71.5 17.2 37.4 17.2 26.3 7.7 47.1 399.6 11.1 6.1 21.7 45.1 214.9 10.2 31.4 16.0 161.1 25.6 36.3 12.3 457.9 1679.9 9.2 8.2 14.3 28.1 22.0 9.7 6.9 20.5 63.9 0.0 35.0 23.2 18.0 14.8 7.4 24.3 29.7 44.2 14.8 11.4 30.0 SIN3A "DKFZP434K2235, KIAA0700" ENSG00000169375 "SIN3 transcription regulator family member A" Q96ST3 15 75369379-75455842 "Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Biological rhythms, Transcription, Transcription regulation" Repressor "Cancer-related genes, Disease variant, Dwarfism, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004506, HPA047213, HPA062123" Enhanced Enhanced Nucleoplasm NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 34: Non-specific - Transcription" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 44: Endometrium - Transcription" Nucleoplasm "CAB004506: AB_2187766, HPA047213: AB_2679984, HPA062123: AB_2684689" "unprognostic (1.94e-1)" "unprognostic (1.38e-1)" "unprognostic (1.48e-1)" "unprognostic (1.27e-1)" "unprognostic (1.99e-1)" "unprognostic (2.90e-1)" "unprognostic (4.74e-2)" "unprognostic (1.91e-1)" "unprognostic (2.26e-1)" "unprognostic (2.15e-1)" "unprognostic (8.52e-2)" "unprognostic (1.37e-1)" "unprognostic (1.17e-3)" "unprognostic (7.33e-2)" "unprognostic (2.19e-1)" "unprognostic (1.33e-1)" "unprognostic (3.52e-1)" 19.2 12.4 10.0 19.8 10.9 42.5 18.0 21.0 11.7 21.0 12.5 19.6 13.8 25.6 16.6 19.1 24.3 17.4 14.8 9.6 13.3 15.1 16.0 18.0 25.9 11.7 12.0 30.0 15.3 22.5 12.1 20.1 10.3 19.7 16.1 24.1 16.6 20.7 16.6 21.5 16.3 19.6 8.3 22.1 16.5 29.6 14.0 43.2 27.2 18.7 26.3 20.2 16.7 10.8 31.2 63.6 55.5 36.7 27.0 28.4 32.1 22.9 35.3 33.0 35.2 35.2 41.2 67.8 23.3 34.0 45.0 54.5 81.2 34.4 35.9 55.0 42.1 64.0 46.2 27.9 20.5 61.4 52.5 34.7 26.1 38.5 39.8 34.0 30.0 47.5 51.5 73.2 27.0 36.2 60.7 39.1 54.2 41.3 26.3 60.5 73.3 41.8 23.6 56.4 43.7 43.7 56.6 25.0 31.0 53.0 38.1 47.9 26.4 40.6 54.5 27.2 34.3 49.8 85.0 70.8 24.2 61.2 23.2 2.9 4.2 5.9 6.3 3.8 9.6 7.0 8.1 8.1 5.2 7.7 8.2 7.2 7.3 8.1 7.4 3.5 7.7 5.7 10.0 10.9 21.0 11.7 9.6 13.3 11.7 12.0 10.3 8.3 14.0 10.8 26.0 35.3 32.4 13.7 35.8 39.4 23.6 21.2 60.9 19.7 36.5 25.4 13.4 17.2 30.5 27.6 31.3 23.5 29.0 17.8 5.9 15.1 10.1 35.7 30.8 32.1 17.3 24.4 19.2 12.8 11.1 24.4 15.3 42.1 29.9 30.1 26.0 17.4 13.2 20.2 18.3 19.0 10.2 21.3 31.7 5.8 23.0 19.5 10.6 27.2 18.8 16.8 24.7 16.6 24.1 14.1 14.0 20.3 33.1 29.8 13.7 9.2 33.4 33.8 13.1 34.7 24.7 42.1 42.7 37.5 53.1 21.9 34.6 21.2 19.2 19.4 SIN3B KIAA0700 ENSG00000127511 "SIN3 transcription regulator family member B" O75182 19 16829398-16880353 "Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" Repressor "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Syncytiotrophoblasts: 124.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA050329 Uncertain Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 71: Testis - DNA repair" "Cluster 28: BEWO - Transcription regulation" "Cluster 52: Non-specific - Transcription" Nucleoplasm "Plasma membrane" "HPA050329: AB_2681089" "unprognostic (2.71e-3)" "unprognostic (8.89e-2)" "unprognostic (1.32e-3)" "unprognostic (6.22e-2)" "unprognostic (1.24e-1)" "unprognostic (2.05e-2)" "unprognostic (5.44e-2)" "unprognostic (9.89e-2)" "unprognostic (5.42e-3)" "unprognostic (2.77e-1)" "prognostic favorable (4.37e-4)" "prognostic unfavorable (3.58e-4)" "unprognostic (1.18e-3)" "unprognostic (8.45e-2)" "unprognostic (1.49e-1)" "unprognostic (9.36e-2)" "unprognostic (1.06e-1)" 38.6 31.7 30.1 21.7 28.4 12.6 42.0 8.6 33.3 57.2 12.7 35.9 15.0 59.3 24.1 25.9 49.9 20.4 27.3 30.1 22.7 31.6 19.8 43.6 26.8 19.8 21.8 58.0 25.5 37.8 32.3 29.0 27.0 43.9 12.3 10.0 30.9 35.2 24.7 32.9 36.4 30.6 10.3 43.0 27.2 51.7 24.8 13.2 42.8 14.9 18.1 34.0 43.7 24.5 28.1 14.7 24.4 31.5 19.7 18.1 76.8 23.3 19.2 31.6 27.9 36.4 25.7 25.0 25.5 27.2 26.7 23.6 20.4 20.9 29.1 26.2 36.8 27.0 35.6 16.7 25.9 15.8 20.8 29.9 26.9 21.3 18.2 25.1 29.1 19.7 22.2 15.0 22.4 33.7 21.7 25.5 30.4 14.6 46.6 28.4 22.4 16.6 18.0 23.5 18.0 22.5 29.6 22.5 18.4 32.5 15.9 14.7 38.6 30.5 18.5 44.6 26.5 21.3 16.8 25.0 21.1 20.6 23.1 0.1 4.2 3.9 1.0 3.8 0.6 3.5 0.9 1.1 1.3 2.7 1.1 0.8 2.0 1.2 3.4 1.5 0.3 1.5 30.1 28.4 8.6 33.3 30.1 22.7 19.8 21.8 27.0 10.3 24.8 24.5 45.4 22.4 11.9 30.7 18.9 7.9 11.6 7.4 14.2 20.3 14.4 18.4 8.3 1.5 8.6 3.7 14.6 21.9 9.5 7.0 3.9 10.6 11.4 16.3 34.6 18.8 4.9 6.9 29.9 8.6 29.2 16.0 13.7 36.2 5.1 29.9 10.8 7.0 17.6 10.1 29.8 8.4 0.0 14.6 5.5 24.2 50.7 13.9 5.4 19.7 14.6 8.0 10.3 21.6 26.3 14.5 4.0 66.5 22.0 14.2 4.2 7.5 6.9 14.5 6.6 17.5 13.7 9.7 9.2 14.4 8.1 124.9 11.7 34.5 7.3 17.9 SLK "KIAA0204, se20-9, STK2" ENSG00000065613 "STE20 like kinase" Q9H2G2 10 103967140-104029233 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Urothelial cells: 201.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015757 Approved Approved "Plasma membrane,Cytosol" NA NA 140000 "Cluster 49: Eosinophils - Unknown function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 22: Epithelial cell types - Mixed function" "Plasma membrane, Cytosol" "HPA015757: AB_1857236" "unprognostic (1.89e-1)" "unprognostic (1.80e-1)" "unprognostic (1.38e-1)" "unprognostic (8.28e-2)" "unprognostic (1.01e-1)" "unprognostic (3.64e-1)" "unprognostic (8.67e-2)" "unprognostic (6.85e-2)" "unprognostic (1.01e-1)" "unprognostic (2.31e-1)" "prognostic unfavorable (2.77e-5)" "unprognostic (1.95e-1)" "prognostic favorable (3.95e-5)" "unprognostic (8.48e-2)" "unprognostic (3.95e-1)" "unprognostic (3.09e-2)" "unprognostic (1.07e-1)" 20.5 15.1 10.9 15.2 19.9 28.9 21.7 20.9 13.7 19.9 15.3 20.4 13.3 21.3 16.2 56.4 14.1 21.3 22.4 11.7 10.0 20.6 17.8 24.0 11.8 11.5 11.1 24.0 16.7 26.3 9.6 25.8 11.7 17.6 20.8 15.1 21.9 17.7 23.1 26.3 14.7 20.6 10.3 14.9 24.1 15.2 12.3 15.2 22.4 25.1 17.5 30.5 28.6 18.5 50.5 28.9 33.7 24.3 36.6 50.1 14.2 30.6 40.7 22.5 20.9 18.4 53.7 26.6 18.6 31.8 19.1 53.7 18.0 39.5 33.5 21.3 24.7 27.0 23.5 15.6 26.6 32.7 22.4 25.5 49.5 30.9 87.6 31.7 40.9 16.9 34.6 17.9 29.8 18.6 23.0 18.0 8.4 32.4 18.2 22.2 41.4 13.8 29.0 60.3 8.0 13.8 26.6 25.7 25.8 17.2 13.8 23.4 63.4 16.6 16.9 30.6 36.3 21.6 28.0 16.7 24.2 43.1 10.7 0.6 0.5 1.7 1.4 0.5 1.5 0.4 0.8 1.0 0.5 0.6 0.6 1.0 2.7 0.5 0.4 0.9 0.8 0.3 10.9 19.9 20.9 13.7 11.7 10.0 11.5 11.1 11.7 10.3 12.3 18.5 73.5 179.5 129.5 38.5 19.9 57.0 87.1 30.9 26.7 32.2 32.0 35.1 110.4 30.0 100.9 44.1 25.0 37.4 40.1 70.0 3.9 34.0 8.4 43.3 77.1 80.2 18.5 25.5 35.3 54.0 13.6 52.6 44.9 90.3 35.3 54.6 50.7 25.3 19.9 25.2 39.3 37.2 18.3 24.5 36.9 16.6 46.6 37.5 8.8 34.7 43.9 25.7 27.8 34.2 63.9 85.5 81.6 63.2 22.3 67.8 21.9 11.5 57.9 25.4 6.6 68.1 49.3 46.3 35.3 61.4 68.5 52.4 44.2 71.7 37.4 201.0 SMARCD3 "BAF60C, CRACD3, Rsc6p" ENSG00000082014 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3" Q6STE5 7 151238764-151277896 "Metabolic proteins, Predicted intracellular proteins" "Neurogenesis, Transcription, Transcription regulation" "Chromatin regulator" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 126.4;skeletal muscle: 129.0" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 67.5;Peritubular cells: 88.4;Sertoli cells: 65.7" "Cancer enhanced" "Detected in all" "glioma: 28.4" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "classical monocyte: 5.5" "Group enriched" "Detected in many" 6 "dendritic cells: 1.6;granulocytes: 1.9;monocytes: 5.5" "Cell line enhanced" "Detected in many" "AN3-CA: 69.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA063955, HPA065517" Uncertain Enhanced Nucleoplasm NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 47: Non-specific - Unknown function" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 48: Smooth muscle cells - ECM organization" Nucleoplasm "HPA063955: AB_2685159, HPA065517: AB_2685500" "unprognostic (1.23e-2)" "unprognostic (2.03e-1)" "prognostic unfavorable (5.50e-4)" "unprognostic (4.38e-3)" "unprognostic (4.67e-1)" "unprognostic (1.41e-3)" "unprognostic (2.24e-2)" "unprognostic (3.52e-2)" "unprognostic (1.63e-1)" "unprognostic (3.50e-1)" "unprognostic (2.08e-3)" "unprognostic (9.18e-2)" "unprognostic (1.02e-1)" "unprognostic (2.05e-3)" "unprognostic (1.34e-1)" "unprognostic (3.35e-3)" "unprognostic (1.29e-1)" 20.7 40.3 104.0 5.0 101.9 7.1 22.1 70.7 126.4 25.0 59.8 25.2 3.0 22.8 14.7 8.4 30.6 14.6 78.9 105.3 90.4 18.8 2.8 18.8 4.6 79.5 89.8 37.6 14.3 27.2 42.2 5.7 83.2 27.7 3.8 10.0 14.3 23.2 129.0 11.5 11.0 13.4 72.4 9.2 18.3 17.4 99.9 1.9 18.1 69.4 2.5 22.7 18.2 84.8 0.8 6.1 19.6 69.3 30.0 13.3 1.6 13.3 13.0 7.5 4.3 4.5 4.2 7.7 4.7 20.4 3.0 1.3 15.7 1.3 3.0 2.4 10.2 0.0 4.5 1.4 25.9 0.4 12.5 31.8 1.8 2.4 0.2 32.7 1.5 19.5 16.4 2.5 39.5 8.3 1.3 10.3 6.1 2.0 2.5 0.5 31.7 0.3 6.6 0.0 11.2 22.6 12.4 2.1 9.5 3.1 2.0 19.7 2.6 6.1 7.7 15.7 4.9 16.1 0.0 6.5 14.2 17.6 21.6 0.4 5.5 0.0 0.1 1.3 0.1 0.1 0.5 0.0 1.6 0.0 0.3 0.5 1.9 0.0 0.2 0.0 0.4 1.3 104.0 101.9 70.7 126.4 105.3 90.4 79.5 89.8 83.2 72.4 99.9 84.8 7.5 6.4 21.7 33.6 0.7 10.7 38.3 3.1 47.8 15.2 28.5 29.6 67.5 21.5 4.6 11.0 4.2 0.4 1.2 0.2 31.3 24.8 2.5 3.9 24.4 5.2 3.5 1.3 16.7 2.6 0.5 28.0 1.5 3.4 2.5 44.3 2.9 0.5 3.6 11.8 23.9 0.3 0.0 17.0 5.7 14.0 50.7 16.0 7.2 8.4 19.7 23.7 0.0 16.1 7.4 2.8 0.1 88.4 0.1 14.6 0.0 2.1 4.7 5.7 65.7 40.9 56.9 1.7 20.0 1.5 4.7 1.1 4.7 22.8 0.2 9.0 SMG1 "ATX, KIAA0421, LIP" ENSG00000157106 "SMG1 nonsense mediated mRNA decay associated PI3K related kinase" Q96Q15 16 18804860-18926408 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Nonsense-mediated mRNA decay" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 31.7" "Lineage enriched" "Detected in all" 4 "granulocytes: 31.7" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006870, HPA031623, HPA073972" Approved Supported Nucleoplasm NA NA "Cluster 42: Non-specific - Transcription" "Cluster 50: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Nucleoplasm "HPA006870: AB_1079725, HPA031623: AB_2673962, HPA073972: AB_2686648" "unprognostic (6.34e-2)" "unprognostic (5.88e-2)" "unprognostic (5.98e-2)" "unprognostic (2.66e-1)" "unprognostic (2.44e-2)" "unprognostic (1.35e-2)" "unprognostic (1.03e-1)" "unprognostic (2.28e-1)" "unprognostic (1.22e-1)" "unprognostic (2.42e-1)" "unprognostic (8.32e-3)" "unprognostic (7.28e-2)" "unprognostic (1.05e-1)" "unprognostic (2.61e-2)" "unprognostic (1.15e-1)" "unprognostic (3.17e-2)" "unprognostic (2.45e-2)" 12.9 8.4 11.0 16.1 11.0 39.0 19.5 42.6 12.6 13.4 11.9 14.4 11.6 14.1 15.8 14.2 12.1 10.8 13.5 12.0 7.5 14.6 17.8 11.4 21.6 7.5 6.7 18.6 13.0 15.2 10.2 11.5 9.9 12.1 15.9 20.9 12.0 10.9 53.1 42.0 13.6 13.2 1.9 15.9 12.8 14.5 12.6 29.9 18.1 35.4 19.1 15.4 13.2 16.6 42.2 27.5 25.5 18.1 28.6 29.9 18.8 19.1 18.8 20.4 22.7 24.4 15.1 57.5 26.8 26.8 21.5 23.3 29.6 16.7 32.3 37.2 18.4 26.2 25.8 31.4 23.1 35.7 19.9 17.7 27.5 42.4 50.5 20.1 29.1 30.7 41.0 31.0 22.8 22.0 24.8 20.9 27.2 15.3 15.7 28.4 34.2 19.8 17.6 32.1 23.0 17.6 29.9 19.9 20.8 20.8 15.9 22.3 37.0 30.2 20.4 19.0 28.7 15.8 21.8 37.0 20.2 27.1 18.6 31.7 2.7 4.2 6.6 3.2 3.2 4.0 4.4 4.8 2.9 7.6 5.7 5.1 8.4 2.6 7.2 5.3 4.5 1.4 11.0 11.0 42.6 12.6 12.0 7.5 7.5 6.7 9.9 1.9 12.6 16.6 83.2 76.9 85.4 58.4 98.8 193.2 73.0 26.9 112.1 52.0 71.3 40.5 48.1 32.9 67.1 27.6 75.0 21.3 97.4 65.5 3.9 21.7 20.3 88.1 81.1 66.5 39.4 44.8 81.5 23.6 19.0 57.3 90.7 140.0 39.3 66.1 37.9 46.1 24.1 42.1 75.2 41.8 36.7 48.0 112.8 24.9 29.8 82.5 39.2 68.4 61.4 20.5 72.1 48.7 87.5 34.6 76.9 26.4 82.2 94.2 43.0 15.6 45.9 44.8 46.0 118.2 63.1 49.6 32.2 107.1 204.4 30.0 97.6 37.6 46.4 95.4 SMURF1 KIAA1625 ENSG00000198742 "SMAD specific E3 ubiquitin protein ligase 1" Q9HCE7 7 99027440-99144108 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Differentiation, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 100.2;Microglial cells: 89.9;Oligodendrocytes: 211.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 9.2;BJ: 15.2;EFO-21: 12.8;HDLM-2: 8.1;PC-3: 18.2;U-2 OS: 8.3;U-251 MG: 9.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019671, HPA055245" Approved Approved Nucleoplasm,Vesicles NA NA "Cluster 72: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Vesicles Nucleoplasm "HPA019671: , HPA055245: AB_2682757" "unprognostic (2.21e-1)" "unprognostic (6.15e-2)" "unprognostic (8.88e-2)" "unprognostic (1.04e-1)" "unprognostic (1.96e-2)" "unprognostic (1.42e-1)" "unprognostic (1.29e-1)" "unprognostic (1.73e-1)" "unprognostic (2.00e-1)" "unprognostic (2.15e-2)" "unprognostic (3.92e-3)" "unprognostic (2.58e-1)" "unprognostic (1.46e-1)" "unprognostic (7.83e-2)" "unprognostic (1.68e-1)" "unprognostic (3.81e-1)" "unprognostic (4.62e-2)" 17.7 13.9 0.7 0.3 0.8 1.1 14.3 0.5 0.9 13.4 1.1 12.7 0.0 12.3 0.0 22.0 12.2 0.0 9.0 0.8 0.3 11.6 11.7 18.5 0.0 1.1 0.7 20.6 15.5 0.0 11.2 0.0 1.0 13.3 0.0 0.7 15.0 0.0 12.7 20.2 11.7 0.0 0.1 10.0 16.1 20.9 0.8 0.0 8.5 0.0 0.0 12.4 15.5 1.8 9.2 0.0 0.1 0.2 0.0 0.0 1.3 15.2 0.1 0.4 0.0 0.0 0.4 1.6 12.8 0.0 0.3 4.5 0.0 0.1 0.0 8.1 2.3 0.0 0.7 0.7 0.1 0.1 3.6 0.0 0.0 0.3 0.0 0.0 0.0 0.0 5.9 0.1 0.8 0.1 1.3 1.9 2.8 0.0 18.2 2.5 1.2 0.0 0.0 0.4 0.3 1.5 0.7 0.5 0.9 0.3 0.3 0.0 1.4 0.0 8.3 1.3 9.4 2.0 4.9 1.3 0.6 1.2 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.8 0.5 0.9 0.8 0.3 1.1 0.7 1.0 0.1 0.8 1.8 9.7 19.2 27.5 59.4 8.9 25.9 25.5 10.0 25.0 28.2 10.3 7.2 4.4 20.0 18.5 12.9 8.4 7.7 4.6 17.1 1.9 14.7 6.2 13.3 8.8 12.8 11.4 0.4 100.2 16.0 10.3 10.8 46.9 23.3 2.5 6.8 9.7 9.3 6.6 26.9 77.0 11.0 4.1 4.1 10.9 8.5 6.2 8.8 8.8 89.9 5.5 3.3 5.2 70.4 211.9 34.8 14.9 13.9 5.4 37.9 7.1 5.5 22.1 7.6 6.6 10.4 15.1 32.8 2.4 19.3 22.0 21.1 8.8 6.5 8.1 77.5 SMURF2 ENSG00000108854 "SMAD specific E3 ubiquitin protein ligase 2" Q9HAU4 17 64542282-64662307 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "BJ: 221.1;HBF TERT88: 157.4;LHCN-M2: 164.1;TIME: 207.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA071508 Enhanced Supported "Nuclear speckles" NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 28: Placenta - Pregnancy" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Nuclear speckles" "HPA071508: AB_2686406" "unprognostic (1.21e-1)" "unprognostic (2.07e-2)" "unprognostic (1.59e-2)" "unprognostic (3.24e-1)" "unprognostic (6.19e-2)" "unprognostic (7.33e-2)" "unprognostic (2.67e-2)" "unprognostic (1.50e-1)" "unprognostic (7.94e-2)" "unprognostic (1.09e-2)" "unprognostic (5.46e-3)" "unprognostic (2.54e-1)" "unprognostic (5.55e-2)" "unprognostic (1.98e-2)" "unprognostic (7.82e-2)" "unprognostic (2.20e-2)" "unprognostic (1.41e-1)" 6.8 4.3 3.3 6.2 3.9 5.9 5.2 5.3 3.4 7.3 3.4 5.3 6.9 5.9 2.3 4.4 5.8 7.1 4.1 3.1 3.3 7.0 3.8 10.5 5.0 4.6 2.7 4.8 6.5 6.3 3.4 13.3 2.8 7.4 4.8 12.5 6.2 5.2 3.0 5.0 10.1 6.1 3.2 5.4 7.8 13.0 3.6 7.8 8.3 6.2 6.5 7.5 3.2 3.8 67.0 17.8 15.3 9.1 11.0 41.5 7.6 221.1 103.2 88.2 73.4 10.4 45.5 8.6 14.5 38.8 29.9 15.2 16.0 37.2 157.4 4.3 12.9 9.1 10.9 11.8 12.0 12.2 5.5 11.8 16.1 109.5 48.5 52.7 97.0 11.9 13.0 7.5 164.1 13.2 28.3 4.8 9.9 8.8 23.8 6.1 38.4 5.2 20.1 11.1 16.0 17.9 14.4 5.8 10.0 24.6 11.7 8.4 207.6 93.8 44.4 39.2 139.6 10.4 11.7 13.9 23.7 7.3 28.4 1.0 0.6 1.4 1.0 0.4 1.1 0.7 0.8 1.1 0.7 0.9 0.9 0.9 1.4 2.7 0.3 0.6 0.2 0.5 3.3 3.9 5.3 3.4 3.1 3.3 4.6 2.7 2.8 3.2 3.6 3.8 40.2 32.1 26.0 96.3 18.6 43.8 30.8 10.0 25.0 26.4 23.3 18.7 10.3 7.2 16.1 9.2 43.8 13.2 35.4 13.8 9.8 18.1 29.0 29.0 37.2 39.3 17.9 2.5 46.1 10.0 3.6 28.1 12.2 39.7 13.3 21.4 38.2 5.1 13.6 26.9 40.9 11.2 10.2 17.3 25.5 9.2 12.5 22.8 21.4 101.2 13.2 21.4 20.6 101.0 52.8 26.5 24.7 12.0 18.0 25.2 28.0 9.6 14.4 46.7 0.0 37.4 23.3 37.1 21.3 13.7 39.8 7.3 33.5 16.2 13.8 24.6 SNRK "FLJ20224, HSNFRK, KIAA0096" ENSG00000163788 "SNF related kinase" Q9NRH2 3 43286512-43424764 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Sertoli cells: 124.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HUVEC TERT2: 126.0;TIME: 74.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042163 Uncertain Approved "Nucleoplasm,Vesicles,Plasma membrane,Cell Junctions" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 48: Smooth muscle cells - ECM organization" "Vesicles, Plasma membrane, Cell Junctions" Nucleoplasm "HPA042163: AB_10794645" "prognostic favorable (9.28e-4)" "unprognostic (8.46e-2)" "unprognostic (2.79e-3)" "unprognostic (6.41e-2)" "unprognostic (1.14e-1)" "unprognostic (1.16e-3)" "unprognostic (2.00e-2)" "unprognostic (1.08e-1)" "unprognostic (2.63e-3)" "unprognostic (4.25e-1)" "unprognostic (2.32e-1)" "unprognostic (4.68e-2)" "prognostic favorable (9.41e-5)" "unprognostic (9.21e-3)" "unprognostic (2.04e-1)" "unprognostic (7.06e-3)" "unprognostic (7.38e-2)" 37.6 10.3 9.7 17.2 9.7 58.4 26.5 27.7 13.2 21.7 9.8 14.6 16.1 23.1 7.8 19.7 13.6 20.4 16.3 9.5 12.5 20.0 25.4 26.4 19.8 14.0 11.5 14.4 22.7 18.5 11.4 33.3 14.7 11.2 11.9 18.8 11.4 10.8 14.3 30.3 17.2 22.9 9.5 33.0 14.4 11.1 13.2 40.5 27.3 21.6 14.7 19.8 21.7 8.7 8.4 5.0 9.1 8.8 26.6 9.5 8.7 8.8 14.8 9.4 9.1 6.9 11.8 13.2 6.8 11.2 6.2 5.3 10.7 18.9 9.6 15.1 8.8 15.0 9.1 8.1 13.8 17.1 16.1 10.5 12.7 10.6 17.9 9.5 126.0 14.9 6.7 14.9 8.7 4.4 17.3 15.0 10.1 4.6 22.6 11.7 6.7 14.0 24.2 14.1 6.4 13.4 7.7 8.1 11.1 7.9 5.5 21.4 74.1 8.2 8.3 9.5 10.4 23.7 18.3 11.0 5.8 20.1 12.0 9.4 4.2 7.6 9.5 7.5 13.0 3.6 8.3 9.6 4.0 3.6 12.1 13.1 27.7 11.0 7.1 1.2 9.7 9.7 9.7 9.7 27.7 13.2 9.5 12.5 14.0 11.5 14.7 9.5 13.2 8.7 88.4 32.1 24.1 30.0 29.0 52.8 10.3 6.4 12.5 52.1 9.7 8.6 17.7 15.7 15.0 16.5 16.7 7.7 57.6 37.0 11.7 10.9 50.4 23.3 16.2 84.2 10.8 10.3 21.6 8.9 3.2 16.4 12.8 19.8 14.5 8.9 98.6 25.2 13.7 30.3 43.2 10.7 12.2 24.8 19.0 7.5 12.5 26.5 23.2 34.7 21.9 16.3 65.9 24.6 10.7 11.2 20.6 11.7 27.3 12.7 25.2 12.2 19.2 18.3 124.9 31.3 49.1 11.1 16.2 13.7 51.3 8.2 61.2 9.5 11.1 18.0 SORD ENSG00000140263 "Sorbitol dehydrogenase" Q00796 15 45023147-45077185 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Disease variant, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "cervix: 163.8;liver: 247.0" "Cell type enhanced" "Detected in many" "Exocrine glandular cells: 138.7;Hepatocytes: 649.4;Prostatic glandular cells: 218.8;Proximal tubular cells: 270.2" "Group enriched" "Detected in all" 4 "liver cancer: 30.3;prostate cancer: 72.5;thyroid cancer: 30.6" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 10 "basophil: 86.3;eosinophil: 55.9" "Lineage enriched" "Detected in all" 12 "granulocytes: 86.3" "Cell line enhanced" "Detected in many" "SK-BR-3: 57.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040260, HPA040621" Enhanced Approved Cytosol NA NA 2800000 "Cluster 52: Eosinophils - Transcription" "Cluster 85: Liver - Metabolism" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Cytosol "HPA040260: AB_10794872, HPA040621: AB_10795384" "unprognostic (8.18e-2)" "unprognostic (7.58e-2)" "unprognostic (8.19e-2)" "unprognostic (1.51e-1)" "unprognostic (5.69e-3)" "unprognostic (3.90e-2)" "prognostic favorable (6.14e-5)" "unprognostic (3.33e-3)" "unprognostic (1.67e-1)" "unprognostic (4.95e-2)" "unprognostic (7.04e-3)" "unprognostic (1.40e-1)" "unprognostic (4.26e-2)" "unprognostic (1.23e-2)" "unprognostic (8.53e-2)" "unprognostic (2.31e-2)" "unprognostic (1.56e-1)" 2.0 15.7 4.9 3.1 3.8 2.8 53.8 7.4 8.4 163.8 1.9 5.3 7.5 4.3 6.9 10.2 6.7 8.2 5.6 5.0 4.5 50.3 247.0 3.2 2.6 4.3 3.7 2.4 5.7 4.4 3.1 2.5 4.0 87.9 7.8 4.8 5.3 27.0 2.2 16.6 7.2 3.5 4.2 2.3 9.2 12.2 3.9 3.7 89.4 2.8 3.4 9.1 6.9 6.3 12.3 12.2 4.7 20.8 4.4 5.3 5.9 1.8 3.5 12.2 7.0 12.2 5.8 2.7 8.0 5.4 4.1 17.6 19.9 19.1 9.2 29.9 12.3 13.5 12.1 50.3 0.2 18.0 25.5 6.7 18.0 6.6 9.5 5.4 12.5 15.1 11.7 10.6 14.9 8.1 18.4 38.3 39.0 29.4 13.8 0.9 16.6 6.4 16.8 12.1 25.1 12.2 2.1 57.3 5.9 5.2 16.4 22.5 4.7 3.5 38.0 1.6 5.8 8.7 4.5 4.4 14.2 18.6 10.6 86.3 1.7 55.9 1.6 1.5 1.7 5.4 1.3 1.6 1.7 6.9 1.6 1.4 3.8 1.1 2.1 2.4 2.5 2.0 4.9 3.8 7.4 8.4 5.0 4.5 4.3 3.7 4.0 4.2 3.9 6.3 3.9 0.0 3.1 5.5 11.9 7.8 26.5 14.8 17.6 10.8 24.7 17.5 3.2 25.8 28.1 33.1 0.0 1.3 2.3 15.0 29.4 68.2 31.7 40.2 17.4 4.9 84.8 37.5 4.8 138.7 5.1 7.5 31.1 43.7 8.8 11.5 15.7 649.4 16.0 3.3 5.4 32.5 22.4 24.2 6.4 24.1 3.7 12.2 16.0 1.0 13.3 9.0 2.1 7.1 8.9 89.0 18.1 6.0 7.9 218.8 8.0 270.2 42.5 4.7 0.0 8.9 8.9 7.4 2.8 35.1 20.3 1.0 6.5 15.3 39.4 131.2 SPEG "APEG1, BPEG, KIAA1297, MGC12676, MYLK6, SPEGalpha, SPEGbeta" ENSG00000072195 "Striated muscle enriched protein kinase" Q15772 2 219434843-219493629 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Differentiation "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 174.8" "Cell type enhanced" "Detected in many" "Astrocytes: 45.7;Cardiomyocytes: 61.5;Late spermatids: 39.6;Sertoli cells: 46.0;Smooth muscle cells: 32.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "hTERT-RPE1: 45.9;U-87 MG: 23.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA018904 Enhanced Approved Vesicles NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 48: Smooth muscle cells - ECM organization" Vesicles "HPA018904: AB_1844924" "unprognostic (3.70e-1)" "unprognostic (1.23e-2)" "unprognostic (5.05e-3)" "unprognostic (2.45e-4)" "unprognostic (2.04e-2)" "unprognostic (4.65e-3)" "unprognostic (2.41e-2)" "unprognostic (1.12e-1)" "unprognostic (8.92e-3)" "unprognostic (2.29e-2)" "unprognostic (8.66e-4)" "unprognostic (1.06e-1)" "unprognostic (3.47e-9)" "unprognostic (1.14e-1)" "unprognostic (7.01e-2)" "unprognostic (5.95e-4)" "unprognostic (1.28e-3)" 16.1 6.8 16.8 7.7 18.7 0.0 15.3 15.5 20.7 75.5 9.7 174.8 5.3 89.5 6.2 15.6 70.0 7.3 48.5 19.8 14.5 4.1 1.3 8.7 0.6 16.1 15.8 21.9 3.4 4.4 34.3 4.5 14.6 58.8 3.8 1.0 10.0 25.5 118.0 7.8 31.9 23.1 15.3 2.4 48.1 5.4 15.3 0.5 5.9 21.7 0.2 87.7 42.1 15.6 6.1 0.5 3.1 4.9 1.6 4.7 1.8 13.1 8.5 8.6 6.4 4.5 1.9 0.0 4.5 9.7 4.3 7.2 2.5 3.1 3.4 0.0 1.7 0.0 6.1 0.3 2.1 0.0 0.5 13.2 4.6 7.8 1.9 45.9 0.0 3.2 3.5 0.0 6.1 1.6 0.1 18.8 6.5 0.0 2.4 2.8 7.0 1.1 8.5 0.0 3.4 15.1 0.6 0.0 0.3 14.3 0.3 0.2 0.0 20.6 21.3 2.4 21.1 0.4 0.0 0.2 23.3 0.1 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 16.8 18.7 15.5 20.7 19.8 14.5 16.1 15.8 14.6 15.3 15.3 15.6 2.4 0.0 2.2 45.7 0.4 3.2 6.0 1.3 2.8 5.3 10.3 14.6 61.5 4.3 0.1 1.8 2.1 0.6 1.4 4.1 0.0 1.5 21.8 0.9 3.6 2.2 6.7 2.7 20.5 1.2 0.9 10.0 3.6 1.3 0.0 1.0 5.7 3.1 1.1 5.0 20.9 4.1 0.0 5.6 1.9 39.6 10.5 1.6 3.6 4.7 1.4 8.4 0.0 5.0 1.0 0.2 3.2 18.8 0.9 6.5 8.5 4.3 0.1 0.9 46.0 17.1 32.4 11.6 3.7 0.2 1.4 1.4 1.2 0.4 3.5 5.3 SRPK1 SFRSK1 ENSG00000096063 "SRSF protein kinase 1" Q96SB4 6 35832966-35921342 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Chromosome partition, Differentiation, Host-virus interaction, mRNA processing, mRNA splicing" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 379.9;Late spermatids: 599.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 61.0" "Lineage enriched" "Detected in all" 4 "granulocytes: 61.0" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016431, HPA056486" Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 31: Spermatids - Spermatogenesis" "Nucleoplasm, Cytosol" "Plasma membrane" "HPA016431: AB_1857478, HPA056486: AB_2683148" "unprognostic (4.65e-3)" "unprognostic (6.82e-3)" "unprognostic (2.54e-3)" "unprognostic (1.01e-3)" "unprognostic (7.74e-2)" "unprognostic (3.31e-2)" "prognostic unfavorable (7.90e-6)" "unprognostic (1.23e-2)" "unprognostic (2.54e-3)" "unprognostic (2.36e-2)" "prognostic unfavorable (6.53e-5)" "unprognostic (7.28e-2)" "unprognostic (2.21e-3)" "unprognostic (9.24e-2)" "unprognostic (4.43e-1)" "unprognostic (1.01e-1)" "unprognostic (7.55e-3)" 8.7 6.0 6.4 18.1 8.2 41.7 14.5 10.0 14.8 12.5 6.8 31.2 25.2 12.7 9.3 23.9 8.6 11.9 8.3 8.9 3.7 16.7 16.0 12.9 19.7 4.0 4.1 8.7 23.3 14.5 9.0 14.5 4.3 9.6 35.6 25.8 16.1 10.9 20.0 26.7 23.6 14.2 2.4 17.8 18.0 44.7 5.2 19.9 8.7 12.6 24.3 31.0 16.2 11.6 104.1 39.2 54.9 82.4 30.2 39.3 69.0 62.1 60.1 57.3 60.2 109.0 34.1 139.0 51.8 39.1 65.5 51.3 110.3 74.2 100.6 96.2 79.9 73.5 42.6 93.8 26.7 111.3 34.0 25.6 39.3 66.0 84.7 44.6 72.3 76.4 157.7 55.6 48.2 36.8 111.1 80.8 45.9 62.9 42.7 77.8 67.3 84.1 56.8 169.5 117.5 42.9 65.4 59.3 42.5 55.2 33.3 70.3 54.8 52.4 41.3 37.2 78.6 33.1 78.6 128.5 20.9 124.3 48.1 61.0 4.4 30.6 8.5 5.3 12.1 8.6 11.2 11.5 5.9 6.9 9.2 10.0 50.9 11.2 7.6 3.3 14.9 6.3 6.4 8.2 10.0 14.8 8.9 3.7 4.0 4.1 4.3 2.4 5.2 11.6 26.6 9.6 25.8 18.6 40.0 42.3 119.3 91.0 67.7 36.8 25.8 22.7 28.7 14.3 51.4 22.0 37.5 54.3 33.1 51.6 29.4 55.4 379.9 29.9 40.2 29.2 46.2 46.7 74.2 68.2 53.2 25.1 46.9 54.0 7.6 44.1 13.2 41.8 21.6 10.1 50.0 50.8 32.6 16.3 19.9 599.1 22.1 20.0 16.0 24.4 31.5 16.8 32.0 30.2 29.7 100.4 47.9 24.8 68.0 117.9 50.8 59.4 33.8 92.9 6.6 17.8 48.9 197.3 100.4 126.8 41.8 39.7 43.6 33.7 90.7 162.6 SRPK2 SFRSK2 ENSG00000135250 "SRSF protein kinase 2" P78362 7 105110704-105399308 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Differentiation, mRNA processing, mRNA splicing" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 108.2" "Group enriched" "Detected in all" 4 "Early spermatids: 1275.7;Late spermatids: 2280.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 219.5" "Lineage enriched" "Detected in all" 5 "granulocytes: 219.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015522, HPA020876" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 78: Testis - Spermatogenesis" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Cytosol" "HPA015522: AB_1857479, HPA020876: AB_1857480" "unprognostic (9.75e-2)" "unprognostic (1.68e-2)" "unprognostic (1.12e-1)" "unprognostic (4.64e-2)" "unprognostic (3.54e-1)" "unprognostic (1.30e-1)" "unprognostic (5.14e-2)" "unprognostic (1.54e-1)" "unprognostic (2.28e-2)" "unprognostic (1.92e-1)" "unprognostic (2.19e-1)" "unprognostic (2.31e-1)" "unprognostic (5.38e-2)" "unprognostic (7.95e-2)" "unprognostic (4.72e-2)" "unprognostic (2.87e-2)" "unprognostic (3.44e-1)" 14.3 16.2 27.2 15.0 29.7 10.7 18.3 20.1 46.8 16.3 0.0 13.3 11.4 18.1 15.8 16.4 14.6 16.0 14.7 31.0 30.0 13.8 14.2 12.8 17.9 27.9 25.5 17.3 14.7 15.1 12.9 17.1 30.4 18.8 14.8 24.2 15.1 14.4 11.3 24.4 11.4 18.3 19.3 17.8 16.3 108.2 26.7 41.4 15.5 11.8 20.6 18.2 11.6 47.1 36.9 24.0 37.3 74.5 39.3 43.8 21.0 35.4 40.8 34.5 39.9 18.9 30.5 23.4 43.7 45.8 38.5 21.6 38.3 37.3 43.7 40.5 33.2 33.1 21.8 16.5 45.1 31.8 47.1 30.6 67.5 29.2 54.6 33.0 59.8 54.4 33.0 92.2 38.5 69.3 118.3 23.9 31.1 20.8 25.9 37.9 41.3 51.1 49.5 56.1 54.8 37.8 40.1 59.0 37.7 49.1 22.1 21.8 39.7 62.9 45.9 60.8 33.4 100.6 106.6 56.5 24.8 32.3 48.1 50.3 30.2 103.3 41.4 21.0 24.8 45.0 31.1 31.6 27.3 44.0 29.3 33.6 219.5 38.7 25.1 23.6 38.6 25.2 27.2 29.7 20.1 46.8 31.0 30.0 27.9 25.5 30.4 19.3 26.7 47.1 35.8 28.9 29.5 128.9 62.9 212.9 60.6 68.1 49.5 76.9 45.2 40.0 23.3 28.6 41.5 23.9 50.1 52.4 87.1 16.6 27.4 52.9 1275.7 54.3 41.9 51.8 28.8 17.2 298.1 46.3 35.6 47.3 40.8 51.6 41.2 48.9 53.6 35.9 47.6 124.5 300.9 35.2 54.9 43.0 42.9 2280.6 76.7 39.2 58.7 168.6 57.0 73.7 103.0 172.4 399.8 36.4 24.4 95.9 54.8 100.7 15.7 25.9 54.2 67.6 46.0 40.3 59.1 198.8 66.0 36.7 103.3 64.4 58.2 61.4 26.1 67.9 SRPK3 "MSSK1, STK23" ENSG00000184343 "SRSF protein kinase 3" Q9UPE1 X 153776412-153785732 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Differentiation, Myogenesis" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 211.4;tongue: 76.8" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 25.0;Cone photoreceptor cells: 8.4;Oligodendrocytes: 7.4;Skeletal myocytes: 18.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "RH-30: 47.0;U-266/70: 19.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 37: Myocytes - Muscle contraction" "unprognostic (1.79e-3)" "unprognostic (6.21e-2)" "unprognostic (1.79e-2)" "unprognostic (7.24e-2)" "unprognostic (1.44e-1)" "unprognostic (2.51e-1)" "unprognostic (1.97e-1)" "unprognostic (4.47e-4)" "unprognostic (2.83e-1)" "unprognostic (1.71e-1)" "unprognostic (4.10e-4)" "unprognostic (8.70e-2)" "unprognostic (5.38e-7)" "unprognostic (1.97e-2)" "unprognostic (1.97e-1)" "unprognostic (3.83e-2)" "unprognostic (1.07e-4)" 1.6 4.3 12.5 2.2 15.8 2.1 1.4 20.2 19.2 3.2 8.7 17.0 3.3 8.4 1.6 6.5 2.9 1.5 47.3 12.2 12.8 1.6 0.7 1.1 2.2 14.6 14.3 2.3 1.6 1.4 18.7 0.5 14.5 7.8 1.7 1.7 7.6 1.1 211.4 5.7 3.9 3.1 11.4 1.9 5.0 1.1 16.0 0.3 0.6 76.8 0.1 6.7 2.7 23.4 5.1 6.7 1.2 3.3 0.0 0.2 1.5 0.6 0.0 0.3 0.1 5.7 0.9 5.1 0.6 0.6 0.5 1.4 0.0 0.1 0.0 4.4 4.6 2.7 5.1 0.9 0.1 1.3 7.6 4.1 0.0 0.0 0.0 0.3 0.0 7.1 3.5 5.8 1.3 10.8 1.0 7.5 1.2 0.3 1.8 2.3 47.0 1.5 0.1 2.3 8.0 3.8 0.0 3.5 1.6 0.5 4.4 5.8 0.1 1.8 4.2 3.5 0.7 19.4 3.5 3.3 1.0 9.5 2.5 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 12.5 15.8 20.2 19.2 12.2 12.8 14.6 14.3 14.5 11.4 16.0 23.4 0.1 0.0 0.0 3.3 0.0 0.6 1.0 0.1 0.0 4.3 2.5 1.0 25.0 0.0 0.1 0.0 8.4 0.0 0.0 0.4 0.0 0.1 0.0 0.6 0.2 0.5 1.2 0.0 0.7 0.0 0.1 1.1 1.5 0.2 0.0 0.2 0.0 0.0 0.0 1.7 1.8 4.0 0.0 0.0 0.2 0.2 0.3 0.1 0.0 0.0 0.1 0.5 0.0 0.5 7.4 0.0 0.0 3.0 0.2 0.7 0.0 0.0 0.1 0.5 0.0 18.9 2.0 0.0 0.2 0.0 0.4 0.0 0.0 0.2 0.6 0.4 SSH1 "KIAA1298, SSH1L" ENSG00000084112 "Slingshot protein phosphatase 1" Q8WYL5 12 108778191-108857590 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Actin-binding, Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "WM-115: 63.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019845 Uncertain Uncertain "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 17: WM-115 - Nervous system development" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Plasma membrane" "Nucleoplasm, Cytosol" "HPA019845: AB_1857497" "unprognostic (1.18e-3)" "unprognostic (3.00e-1)" "unprognostic (2.49e-1)" "unprognostic (2.70e-2)" "unprognostic (9.40e-2)" "unprognostic (7.45e-2)" "prognostic unfavorable (5.80e-5)" "unprognostic (3.28e-2)" "unprognostic (3.69e-2)" "unprognostic (1.72e-3)" "unprognostic (7.12e-2)" "unprognostic (3.42e-1)" "unprognostic (1.71e-2)" "unprognostic (1.41e-1)" "unprognostic (8.66e-2)" "unprognostic (9.55e-2)" "unprognostic (6.22e-2)" 6.6 5.1 5.6 5.1 5.1 7.9 5.0 9.2 5.5 5.8 7.2 7.2 2.9 5.9 4.0 5.5 5.3 5.3 7.8 5.7 5.3 6.7 5.5 11.8 4.1 5.8 5.7 5.0 4.3 5.4 5.2 5.2 5.2 5.2 4.1 5.7 3.9 4.8 11.9 4.6 5.1 5.5 5.0 7.5 4.9 3.5 5.1 3.6 5.3 6.5 4.2 6.0 5.2 5.1 9.9 12.7 8.2 6.4 15.1 12.8 7.2 12.8 26.1 11.0 9.7 6.4 4.6 4.9 8.7 29.0 18.8 9.8 4.9 20.7 8.9 9.9 4.8 11.3 6.0 4.0 8.1 5.8 28.4 17.7 7.0 10.0 22.0 27.1 10.3 5.6 2.5 3.6 29.1 5.4 6.6 8.0 5.8 3.8 10.3 4.6 9.8 6.1 4.5 17.1 6.1 8.1 11.0 2.8 24.2 11.2 3.9 4.8 8.1 19.6 8.4 11.9 7.1 7.3 7.0 5.6 10.3 4.5 63.1 1.8 0.9 2.0 1.0 1.5 0.9 0.6 0.5 0.9 0.6 0.6 0.4 0.5 2.1 0.7 1.2 0.7 0.6 0.5 5.6 5.1 9.2 5.5 5.7 5.3 5.8 5.7 5.2 5.0 5.1 5.1 34.5 9.6 16.1 26.1 6.3 9.4 20.8 23.6 19.4 12.9 6.9 6.6 25.1 11.5 12.7 14.7 16.7 6.0 18.5 8.2 5.9 8.4 2.2 10.8 17.1 52.2 5.4 7.8 27.3 8.2 4.4 14.0 13.7 16.9 20.8 12.0 29.3 15.2 12.3 11.8 35.4 5.4 0.0 23.0 20.3 5.0 6.5 21.1 12.4 55.3 33.7 7.8 14.4 14.1 14.8 12.3 2.4 12.8 13.1 21.8 4.0 6.7 9.0 19.1 6.6 17.8 18.1 1.4 7.7 13.2 8.9 2.3 17.9 7.6 7.8 13.9 SSH2 KIAA1725 ENSG00000141298 "Slingshot protein phosphatase 2" Q76I76 17 29625938-29930276 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Actin-binding, Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 91.5" "Cell type enhanced" "Detected in all" "Excitatory neurons: 269.0;Inhibitory neurons: 255.2;Microglial cells: 254.8;Oligodendrocytes: 547.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "eosinophil: 134.8" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017189, HPA057099" Uncertain NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 59: Non-specific - Transcription" "CAB017189: , HPA057099: AB_2683336" "unprognostic (1.45e-1)" "unprognostic (1.57e-1)" "unprognostic (3.56e-2)" "unprognostic (1.27e-2)" "unprognostic (1.44e-1)" "unprognostic (1.53e-1)" "unprognostic (3.00e-3)" "unprognostic (7.05e-2)" "unprognostic (1.14e-1)" "unprognostic (6.80e-2)" "unprognostic (9.80e-3)" "unprognostic (7.52e-2)" "unprognostic (1.48e-2)" "unprognostic (8.28e-2)" "unprognostic (7.70e-2)" "unprognostic (2.74e-1)" "unprognostic (1.86e-1)" 15.6 9.5 11.7 22.5 13.1 62.8 10.7 12.8 16.3 7.1 3.6 13.0 8.3 7.3 8.9 12.7 8.2 8.9 19.4 13.1 23.2 15.1 13.6 21.4 29.0 19.0 14.4 3.9 14.6 6.2 7.1 10.4 18.5 6.3 10.9 8.1 10.7 4.5 91.5 14.4 20.7 7.9 11.4 28.3 15.5 28.2 16.3 28.9 13.9 35.6 24.8 9.0 8.7 24.5 25.8 19.0 12.6 10.8 36.1 24.7 8.8 12.3 12.9 19.6 19.2 12.9 9.0 22.1 18.8 14.1 12.6 31.0 14.8 17.1 22.4 7.1 28.1 14.9 21.2 17.4 16.6 16.7 30.7 30.4 12.3 20.6 13.4 9.7 47.3 36.2 9.9 16.8 13.7 7.3 74.9 15.5 9.4 9.3 11.5 37.9 31.9 37.0 35.7 20.3 20.6 32.3 18.0 18.6 36.6 16.3 12.6 19.4 25.6 12.6 26.3 23.5 16.1 26.9 20.0 53.8 16.4 13.1 12.3 47.2 15.2 134.8 10.4 20.2 8.5 21.3 11.6 11.1 12.7 22.4 11.5 8.7 91.6 4.6 36.7 7.7 16.4 6.5 11.7 13.1 12.8 16.3 13.1 23.2 19.0 14.4 18.5 11.4 16.3 24.5 19.6 9.6 38.5 81.6 137.0 39.6 12.3 20.6 27.9 12.4 22.2 19.2 28.2 12.8 23.2 16.5 27.1 20.4 68.7 54.3 25.4 14.9 108.4 27.9 10.1 26.9 35.4 27.8 269.0 35.5 26.4 22.2 33.1 32.5 12.6 6.0 19.6 26.9 22.3 20.2 255.2 34.8 14.2 120.2 31.3 174.4 12.2 75.9 35.6 254.8 83.6 9.2 82.4 184.0 547.9 40.3 38.6 8.2 49.4 12.9 64.5 63.1 18.4 22.9 6.6 34.4 17.0 80.9 16.7 37.6 36.2 18.2 65.8 14.2 21.6 30.2 SSH3 "FLJ10928, FLJ20515" ENSG00000172830 "Slingshot protein phosphatase 3" Q8TE77 11 67303478-67312607 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 11.6;eosinophil: 11.1" "Lineage enriched" "Detected in many" 5 "granulocytes: 11.6" "Cell line enhanced" "Detected in many" "HaCaT: 64.9;MCF7: 64.1;RT4: 111.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019949, HPA019957" Approved Approved "Nuclear speckles,Plasma membrane,Actin filaments,Cytosol" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 15: RT4 - Unknown function" "Cluster 30: Mammary glandular cells - Lactation" "Nuclear speckles, Cytosol" "Plasma membrane, Actin filaments" "HPA019949: AB_1857498, HPA019957: AB_1857499" "unprognostic (4.38e-2)" "unprognostic (1.37e-1)" "unprognostic (3.50e-3)" "unprognostic (3.73e-2)" "unprognostic (2.61e-3)" "unprognostic (9.30e-2)" "unprognostic (2.99e-1)" "unprognostic (1.84e-1)" "unprognostic (1.63e-1)" "unprognostic (2.45e-2)" "prognostic unfavorable (2.89e-4)" "unprognostic (1.50e-1)" "unprognostic (2.06e-2)" "unprognostic (1.47e-1)" "unprognostic (3.20e-1)" "unprognostic (4.94e-3)" "unprognostic (6.78e-3)" 14.4 7.8 8.9 4.0 12.0 9.3 16.2 14.1 11.6 25.9 9.5 19.3 13.3 16.0 7.5 41.9 18.3 11.5 12.5 9.1 10.1 13.1 10.9 12.7 3.1 14.6 10.8 23.5 15.3 9.8 9.7 6.5 13.2 29.9 9.3 1.2 26.2 28.8 6.8 25.2 15.0 6.1 12.3 9.4 20.1 2.3 11.5 1.9 16.3 3.8 4.8 37.4 32.5 14.9 17.3 18.7 0.4 0.6 11.4 11.8 18.8 10.3 13.7 5.6 5.1 21.2 46.8 1.0 32.5 10.5 11.9 64.9 6.0 46.4 2.8 3.6 6.3 4.3 32.2 9.9 8.2 0.9 16.0 12.2 40.5 8.3 8.3 12.9 6.3 0.4 0.1 1.5 6.2 64.1 0.8 7.3 4.2 48.9 13.8 20.6 0.6 3.1 18.2 111.2 3.7 5.8 24.8 41.0 12.8 6.3 57.1 15.3 10.4 4.5 9.8 12.7 2.7 1.5 0.9 0.5 12.7 6.9 4.9 11.6 1.5 11.1 2.0 2.3 1.7 0.2 1.9 1.7 1.7 0.1 0.8 0.8 4.4 1.5 1.1 1.1 1.8 1.1 8.9 12.0 14.1 11.6 9.1 10.1 14.6 10.8 13.2 12.3 11.5 14.9 7.6 3.2 8.7 8.5 0.9 7.0 20.8 25.2 11.4 0.8 21.3 17.3 3.8 20.0 23.4 16.5 0.0 15.1 3.3 28.3 3.9 19.4 0.1 8.3 5.6 4.7 3.6 5.2 4.2 21.6 24.9 8.0 20.9 17.8 3.8 8.1 3.9 5.0 7.7 1.7 5.3 14.4 24.4 6.2 3.1 0.6 13.1 4.8 8.8 2.8 9.2 4.8 7.2 0.0 15.9 20.0 21.0 12.0 0.7 15.4 20.2 7.4 11.6 0.5 0.0 4.9 9.2 0.5 0.4 27.0 10.4 15.7 4.4 5.3 21.4 26.8 SSU72 HSPC182 ENSG00000160075 "SSU72 homolog, RNA polymerase II CTD phosphatase" Q9NP77 1 1541673-1574863 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "mRNA processing" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 700.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA069290, HPA070604" Supported Approved Nucleoplasm,Cytosol No No "Cluster 52: Eosinophils - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Cytosol" "HPA069290: AB_2686108, HPA070604: AB_2686285" "unprognostic (3.33e-2)" "unprognostic (2.79e-2)" "unprognostic (6.37e-2)" "unprognostic (2.27e-2)" "unprognostic (2.41e-1)" "unprognostic (9.84e-2)" "unprognostic (2.40e-3)" "unprognostic (2.43e-2)" "unprognostic (3.23e-1)" "unprognostic (3.23e-1)" "unprognostic (6.75e-2)" "unprognostic (1.36e-1)" "unprognostic (6.56e-3)" "unprognostic (1.19e-1)" "unprognostic (8.51e-2)" "unprognostic (3.77e-1)" "unprognostic (1.06e-1)" 105.4 77.3 101.9 64.1 107.4 61.0 94.8 101.9 119.7 82.1 112.6 95.9 75.1 80.4 88.3 123.3 80.6 52.7 131.5 106.2 113.3 105.5 122.4 87.9 74.3 106.6 106.6 81.9 115.0 63.4 99.9 52.0 109.0 86.8 62.7 52.1 100.6 53.6 246.7 100.2 90.8 53.8 103.4 105.9 96.1 58.9 113.2 65.1 107.8 136.3 67.7 83.6 87.2 103.9 204.6 127.6 90.2 140.3 152.1 145.4 92.2 172.8 134.1 147.6 152.5 120.8 229.7 205.4 92.1 137.0 143.7 155.0 147.4 142.5 142.8 172.8 173.9 129.3 110.7 193.8 171.5 165.6 108.4 130.7 117.8 158.4 149.8 123.2 140.1 122.6 227.9 154.1 118.6 181.4 190.8 264.5 158.5 198.9 191.5 149.5 145.5 289.8 163.7 61.8 166.1 114.0 117.1 296.3 535.3 152.0 154.6 142.0 107.8 140.8 89.2 160.9 150.7 186.5 241.2 258.1 148.0 260.1 69.9 143.4 93.0 188.6 80.0 98.9 99.3 120.7 105.9 95.9 100.2 117.7 127.6 105.1 204.1 75.3 91.7 62.9 161.5 101.0 101.9 107.4 101.9 119.7 106.2 113.3 106.6 106.6 109.0 103.4 113.2 103.9 107.5 28.9 72.7 14.7 130.6 186.2 138.9 100.0 108.1 95.9 169.6 173.7 92.4 151.5 69.2 101.2 20.9 208.6 129.9 171.2 291.6 76.3 283.0 107.8 77.6 91.5 142.0 78.8 23.3 106.6 239.4 84.4 89.7 101.0 61.5 90.6 98.6 132.7 141.1 112.7 23.8 165.8 83.4 178.4 130.0 700.2 104.7 123.3 167.2 15.9 144.8 152.3 193.6 25.6 20.1 91.9 206.7 85.7 132.5 199.6 242.8 325.8 59.0 73.4 59.2 77.6 136.6 97.1 157.4 155.9 220.4 245.3 128.1 86.2 172.1 153.2 STAMBP AMSH ENSG00000124356 "STAM binding protein" O95630 2 73828916-73873659 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 12 "LHCN-M2: 1108.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035800, HPA035801" Uncertain Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA 18000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 80: Striated muscle - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "Plasma membrane, Cytosol" "HPA035800: AB_10670591, HPA035801: AB_2732470" "unprognostic (1.86e-2)" "unprognostic (1.14e-1)" "unprognostic (2.16e-1)" "prognostic unfavorable (4.70e-5)" "unprognostic (6.13e-2)" "unprognostic (2.08e-3)" "unprognostic (3.73e-2)" "unprognostic (1.71e-1)" "unprognostic (6.58e-2)" "unprognostic (2.96e-2)" "prognostic unfavorable (5.79e-4)" "unprognostic (1.01e-1)" "unprognostic (2.29e-1)" "unprognostic (7.72e-2)" "unprognostic (2.63e-1)" "unprognostic (1.43e-1)" "unprognostic (2.89e-1)" 15.6 11.6 21.7 14.6 30.6 13.3 20.2 29.7 23.8 19.3 19.3 21.5 20.7 20.6 15.5 25.4 18.3 16.9 22.3 20.6 24.5 21.9 19.0 15.7 19.3 31.3 28.0 17.7 12.2 24.3 9.3 17.3 30.4 22.1 23.2 14.6 21.5 15.6 37.4 16.7 20.4 21.3 27.9 14.9 18.2 15.8 27.1 23.2 22.6 42.8 21.6 16.8 16.0 38.6 39.0 44.0 34.0 31.6 31.1 37.2 39.1 23.3 31.7 42.1 40.3 73.7 35.9 32.2 35.8 19.8 55.7 30.0 36.6 81.7 47.6 56.6 41.3 43.3 29.1 58.1 43.4 35.8 50.0 30.1 57.6 49.6 70.7 53.5 25.1 43.7 47.9 47.8 1108.9 46.8 55.9 32.4 54.9 55.1 22.7 38.6 89.4 46.1 45.2 43.0 62.0 45.8 28.4 34.6 49.1 36.4 32.3 21.4 22.0 37.5 44.5 22.9 41.9 44.8 46.9 24.9 46.4 38.1 44.7 30.7 18.9 34.2 15.9 21.4 17.2 21.5 18.3 15.6 19.9 19.3 18.9 14.4 27.6 22.3 19.9 19.5 25.8 14.9 21.7 30.6 29.7 23.8 20.6 24.5 31.3 28.0 30.4 27.9 27.1 38.6 22.1 19.2 17.7 22.9 21.5 16.3 28.9 61.7 31.3 22.3 28.8 27.7 41.1 28.6 34.4 25.8 12.5 43.0 27.4 48.7 49.0 37.9 80.8 35.6 37.3 21.4 10.3 34.9 18.5 36.3 32.5 26.0 18.8 45.8 52.6 21.2 17.5 41.1 33.0 26.9 22.1 36.4 40.7 27.7 16.2 125.0 32.6 25.2 7.2 16.9 34.1 24.9 25.7 26.2 67.2 44.5 41.8 34.6 21.5 40.9 57.2 68.8 24.5 21.0 39.5 28.2 27.2 33.1 44.2 44.5 21.6 44.5 21.4 27.5 34.3 27.1 STAMBPL1 "ALMalpha, AMSH-FP, AMSH-LP, bA399O19.2, FLJ31524, KIAA1373" ENSG00000138134 "STAM binding protein like 1" Q96FJ0 10 88879734-88975153 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 23.8" "Cell type enhanced" "Detected in many" "Early spermatids: 54.3;Excitatory neurons: 60.5;Microglial cells: 32.8;Spermatocytes: 40.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040202 Uncertain Approved "Plasma membrane" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 14: B-cells - Humoral immune response" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" "HPA040202: AB_10805708" "unprognostic (2.73e-1)" "unprognostic (1.95e-1)" "unprognostic (7.56e-2)" "unprognostic (4.25e-2)" "unprognostic (6.46e-2)" "unprognostic (6.27e-2)" "unprognostic (1.68e-2)" "unprognostic (1.05e-2)" "unprognostic (4.67e-2)" "unprognostic (8.20e-2)" "unprognostic (2.78e-1)" "unprognostic (6.57e-2)" "prognostic unfavorable (1.08e-5)" "unprognostic (4.41e-2)" "unprognostic (4.06e-2)" "unprognostic (1.50e-1)" "unprognostic (4.40e-3)" 3.9 23.8 5.5 10.4 6.5 5.3 2.5 2.6 9.0 2.7 0.0 8.7 6.4 4.2 0.9 4.4 2.2 4.1 8.0 6.2 1.4 1.8 1.8 3.6 16.2 1.1 0.5 12.7 2.3 3.4 5.5 1.2 2.6 1.7 9.7 4.4 1.4 1.1 0.7 3.7 7.3 3.0 1.9 7.2 5.1 18.0 0.5 7.1 1.2 1.5 12.2 6.4 2.5 5.6 14.8 16.5 1.0 0.6 14.4 27.7 0.0 31.5 28.9 19.0 16.3 0.3 25.6 18.6 2.3 15.6 12.3 6.4 4.1 4.5 17.9 16.3 10.8 4.6 10.4 0.9 10.3 20.2 5.7 10.6 1.4 31.6 9.6 18.4 0.6 20.9 0.0 7.3 50.0 3.0 34.2 21.5 6.6 13.3 14.1 3.4 13.0 3.8 6.5 4.7 9.6 11.9 3.7 1.1 37.5 3.6 2.3 4.1 4.9 17.0 12.4 20.7 19.9 17.7 19.7 17.2 18.2 19.4 16.9 9.5 1.0 8.1 10.7 1.1 14.1 17.7 15.5 13.7 1.7 14.9 16.6 10.0 1.4 23.6 0.5 27.9 28.3 8.0 5.5 6.5 2.6 9.0 6.2 1.4 1.1 0.5 2.6 1.9 0.5 5.6 2.3 0.0 4.5 10.7 16.7 9.6 5.3 1.4 1.2 3.6 2.3 1.4 8.6 0.0 0.2 5.5 0.0 0.1 18.8 7.6 0.0 1.3 54.3 1.9 6.5 1.8 9.1 3.4 60.5 1.8 0.1 7.7 3.1 1.4 5.1 7.4 1.8 2.4 3.7 6.7 26.2 9.3 4.1 1.3 9.6 20.7 7.2 3.1 0.0 32.8 1.0 9.3 12.3 26.2 1.9 1.9 2.8 1.5 14.2 1.9 7.9 0.8 5.0 0.4 0.0 20.4 6.4 40.2 2.5 5.9 11.4 0.1 17.6 14.9 14.2 2.9 STK10 "LOK, PRO2729" ENSG00000072786 "Serine/threonine kinase 10" O94804 5 172042079-172188224 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 76.5;lymphoid tissue: 45.2" "Cell type enhanced" "Detected in all" "dendritic cells: 107.7;Kupffer cells: 91.4;NK-cells: 171.0;T-cells: 81.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "WM-115: 143.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015083, CAB020840" Enhanced Approved "Nucleoplasm,Plasma membrane" NA NA 16000 "Cluster 51: Monocytes - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 17: WM-115 - Nervous system development" "Cluster 63: NK-cells & T-cells - Immune response" "Nucleoplasm, Plasma membrane" "CAB020840: , HPA015083: AB_2669151" "unprognostic (1.17e-1)" "unprognostic (5.43e-2)" "prognostic favorable (2.76e-4)" "unprognostic (2.88e-1)" "unprognostic (6.96e-3)" "unprognostic (1.02e-1)" "unprognostic (5.25e-3)" "unprognostic (3.07e-2)" "unprognostic (1.07e-1)" "unprognostic (1.03e-1)" "unprognostic (2.65e-1)" "unprognostic (3.43e-1)" "prognostic unfavorable (1.63e-4)" "unprognostic (1.09e-1)" "unprognostic (1.01e-2)" "unprognostic (3.10e-1)" "unprognostic (1.84e-1)" 14.9 5.7 3.1 37.1 3.6 76.5 11.4 18.4 5.6 4.5 3.5 8.5 8.4 4.9 1.7 5.6 4.7 13.2 7.6 3.1 4.0 5.9 6.2 18.4 44.1 6.2 4.4 2.5 7.2 3.1 4.1 17.2 5.8 4.4 6.9 1.2 4.7 3.5 5.0 14.2 16.0 7.8 5.4 45.2 11.1 14.0 6.4 20.6 5.3 5.5 25.0 14.9 5.2 7.0 22.2 20.2 12.7 18.8 14.7 18.1 31.5 28.4 24.0 20.2 18.9 10.6 28.6 26.8 14.6 35.6 42.3 25.4 5.7 35.1 13.5 35.0 9.3 32.1 8.2 6.1 20.2 32.7 36.4 17.4 7.5 27.4 23.1 7.5 18.3 10.4 3.0 36.2 14.7 35.7 23.5 73.4 5.0 11.3 16.1 38.2 9.9 17.7 8.2 27.6 8.3 10.2 16.4 22.5 77.9 15.6 8.2 68.7 24.8 22.3 11.3 15.8 15.5 30.2 48.4 17.1 29.4 49.8 143.3 16.7 26.5 23.4 36.5 46.3 26.9 10.0 19.3 26.3 22.5 8.1 11.0 20.0 48.9 16.9 71.8 7.1 26.7 44.0 3.1 3.6 18.4 5.6 3.1 4.0 6.2 4.4 5.8 5.4 6.4 7.0 35.8 3.2 11.2 1.6 40.5 6.6 8.4 7.2 5.7 4.3 3.3 3.7 3.8 5.7 6.1 1.8 6.2 4.1 107.7 11.8 1.9 4.5 2.5 3.5 4.6 23.9 12.0 11.8 8.5 6.2 27.2 9.3 20.9 7.1 28.4 3.6 18.2 2.3 36.3 47.1 7.9 19.9 2.0 91.4 43.8 3.2 2.8 61.3 8.8 32.8 49.8 2.1 171.0 10.1 14.4 10.7 11.8 1.5 42.8 11.7 6.5 2.0 6.1 2.2 13.1 5.1 10.2 5.3 7.8 2.6 4.1 5.1 81.4 11.4 5.3 10.7 STK11 "LKB1, PJS" ENSG00000118046 "Serine/threonine kinase 11" Q15831 19 1177558-1228431 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Autophagy, Cell cycle, Differentiation, DNA damage, Spermatogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 154.9;Late spermatids: 338.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 9.9" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB016231, HPA017254, CAB022105, HPA067481" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 59: Non-specific - Translation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 31: Spermatids - Spermatogenesis" Nucleoplasm Cytosol "CAB016231: AB_627890, CAB022105: , HPA017254: AB_1852924, HPA067481: AB_2685847" "unprognostic (8.60e-2)" "unprognostic (1.68e-1)" "unprognostic (5.00e-2)" "prognostic favorable (3.69e-5)" "unprognostic (2.04e-2)" "prognostic favorable (1.96e-4)" "unprognostic (9.11e-3)" "unprognostic (3.19e-1)" "unprognostic (9.08e-2)" "unprognostic (1.26e-1)" "unprognostic (1.95e-3)" "unprognostic (7.70e-3)" "unprognostic (3.54e-2)" "unprognostic (3.16e-2)" "unprognostic (1.60e-1)" "unprognostic (3.31e-1)" "unprognostic (3.12e-3)" 32.1 44.2 18.8 18.2 15.5 34.1 32.3 24.8 23.5 35.4 24.7 38.7 25.6 33.6 5.5 39.7 34.9 11.8 48.4 18.3 14.7 36.4 45.5 30.5 20.5 19.2 19.4 37.9 34.2 16.1 36.8 12.6 15.2 39.3 7.7 5.7 29.7 16.1 108.2 40.2 37.7 9.6 16.3 48.3 38.1 102.4 17.6 15.0 34.3 27.7 12.9 34.4 35.0 14.9 50.0 25.8 19.9 35.9 18.6 17.0 35.5 24.0 27.7 25.1 25.4 22.5 37.1 31.9 24.8 27.8 11.2 32.3 20.1 41.9 8.2 60.2 37.8 34.8 1.7 26.4 38.1 36.6 53.5 30.5 28.9 19.4 29.2 22.3 25.2 28.1 63.1 51.1 13.9 39.3 31.9 27.7 33.0 19.6 25.1 50.0 20.0 36.1 21.1 39.7 39.8 26.6 0.0 19.7 24.2 11.4 30.3 55.2 33.7 24.6 25.0 45.2 38.7 85.3 38.1 25.7 22.6 48.1 25.5 1.7 3.3 3.9 0.4 5.5 0.3 2.3 0.8 1.4 1.6 0.7 0.7 0.6 9.9 1.4 5.7 0.8 0.6 0.5 18.8 15.5 24.8 23.5 18.3 14.7 19.2 19.4 15.2 16.3 17.6 14.9 24.5 6.4 13.7 12.7 10.5 16.7 7.4 9.5 9.6 25.5 22.0 18.4 13.7 15.7 9.0 23.9 18.8 7.5 20.1 44.4 7.9 9.4 154.9 18.0 18.1 15.7 15.0 27.3 7.9 14.0 5.3 13.2 21.9 17.8 2.5 80.3 15.4 31.6 15.2 18.5 8.5 33.1 6.1 18.3 26.4 338.7 24.5 20.7 16.0 11.2 20.4 21.2 9.2 9.0 6.5 16.7 29.3 20.7 10.2 15.1 27.5 11.0 9.3 21.0 13.1 21.5 23.7 85.5 20.1 14.6 15.5 8.8 16.6 45.2 35.4 12.6 STK16 "MPSK, PKL12" ENSG00000115661 "Serine/threonine kinase 16" O75716 2 219245455-219250337 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029450 Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 34: Spermatids - Unknown function" Cytosol "Nucleoplasm, Plasma membrane" "HPA029450: AB_10603118" "unprognostic (1.99e-1)" "unprognostic (2.08e-1)" "unprognostic (5.84e-2)" "prognostic favorable (6.09e-4)" "unprognostic (6.21e-2)" "unprognostic (5.55e-2)" "unprognostic (4.98e-3)" "unprognostic (4.25e-1)" "unprognostic (1.48e-1)" "unprognostic (4.22e-2)" "unprognostic (1.73e-2)" "unprognostic (3.17e-1)" "unprognostic (4.39e-3)" "unprognostic (1.76e-1)" "unprognostic (2.00e-1)" "unprognostic (2.68e-1)" "unprognostic (1.34e-1)" 15.2 24.9 17.6 11.8 17.5 15.0 16.2 16.3 20.5 14.0 19.5 20.0 17.3 13.8 20.8 22.8 18.1 13.0 19.0 16.5 16.8 26.5 43.2 14.3 17.6 17.9 17.5 14.8 30.9 22.7 19.8 9.2 16.9 20.3 13.5 7.9 20.0 10.9 14.4 17.3 17.8 9.9 17.4 21.2 24.2 27.7 18.6 20.5 19.3 8.2 14.5 17.8 14.8 16.5 14.1 18.8 15.7 13.2 40.0 40.0 17.9 17.8 23.6 14.3 14.7 21.2 31.0 8.3 24.4 32.0 23.4 14.5 18.5 30.0 7.8 20.0 19.8 17.7 15.4 19.1 34.9 17.6 20.1 40.1 48.1 20.8 57.4 29.8 17.9 18.7 23.1 21.5 26.8 27.1 19.4 38.0 14.5 25.7 10.3 18.1 17.5 24.9 32.2 16.1 12.3 14.6 5.8 25.5 39.0 11.2 27.4 36.4 13.7 20.6 14.0 16.4 17.4 25.9 12.1 19.5 22.9 18.4 18.3 1.6 7.0 5.3 4.9 3.8 5.5 7.2 6.0 9.2 6.8 6.0 6.1 7.9 4.1 14.5 3.1 5.8 7.3 8.7 17.6 17.5 16.3 20.5 16.5 16.8 17.9 17.5 16.9 17.4 18.6 16.5 11.8 6.4 5.6 3.6 22.4 9.8 18.1 32.6 24.5 7.9 31.8 31.8 9.5 24.3 19.7 7.3 16.7 24.0 23.6 27.6 68.4 40.3 87.2 21.4 13.3 14.0 25.8 36.0 2.2 58.5 25.0 15.8 17.3 12.9 8.2 17.9 12.5 43.7 28.4 13.5 2.7 38.7 16.2 27.1 17.6 70.3 15.2 17.8 21.4 0.0 38.4 22.1 44.3 4.0 6.8 33.3 44.3 13.5 27.6 18.6 58.9 80.2 19.6 19.1 0.0 11.9 19.2 43.1 9.6 28.2 11.2 12.9 22.1 33.6 34.2 20.8 STK17A DRAK1 ENSG00000164543 "Serine/threonine kinase 17a" Q9UEE5 7 43582758-43650713 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 644.6;T-cells: 273.7;Urothelial cells: 326.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018138, HPA037979" Uncertain Supported "Nuclear speckles,Plasma membrane" Yes No "Cluster 48: NK-cells - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 22: Epithelial cell types - Mixed function" "Nuclear speckles" "Plasma membrane" "HPA018138: AB_2669784, HPA037979: AB_10795247" "unprognostic (1.81e-3)" "unprognostic (1.08e-2)" "unprognostic (2.67e-1)" "unprognostic (5.41e-2)" "unprognostic (5.11e-2)" "unprognostic (3.35e-2)" "unprognostic (1.03e-2)" "unprognostic (9.15e-3)" "unprognostic (2.07e-1)" "unprognostic (6.34e-2)" "unprognostic (1.36e-2)" "unprognostic (6.61e-2)" "unprognostic (2.99e-3)" "unprognostic (3.76e-2)" "unprognostic (3.08e-1)" "unprognostic (1.97e-3)" "unprognostic (3.66e-1)" 6.7 8.1 3.9 7.9 4.2 4.8 5.2 6.9 4.9 4.0 4.0 6.4 3.2 3.5 1.2 7.2 3.9 5.3 10.8 4.0 4.1 6.3 4.6 9.4 14.4 3.4 4.4 6.2 9.1 0.8 4.2 3.2 3.6 4.3 2.4 5.5 5.8 2.1 9.9 4.6 11.5 3.3 3.6 12.6 9.5 9.0 4.3 9.0 3.8 2.5 13.5 5.6 5.0 3.1 5.8 8.2 9.0 5.3 7.8 8.3 1.9 12.3 15.1 6.6 5.9 7.5 3.1 7.9 20.2 15.3 17.8 8.5 3.6 17.4 10.4 16.9 7.0 9.3 8.2 8.4 4.9 21.1 5.6 6.4 26.4 8.2 8.6 36.4 12.6 11.0 16.7 15.1 9.6 3.6 18.2 8.0 17.3 4.1 18.3 8.4 6.9 14.2 15.6 6.7 6.9 11.2 8.1 8.5 6.1 13.6 6.5 10.8 16.9 20.7 8.3 14.3 17.2 13.3 11.2 13.5 18.4 14.0 31.7 0.5 0.0 2.7 2.0 0.0 1.5 2.4 2.0 3.2 0.1 2.2 3.0 3.0 1.6 4.9 0.1 0.4 1.3 0.9 3.9 4.2 6.9 4.9 4.0 4.1 3.4 4.4 3.6 3.6 4.3 3.1 44.2 121.8 33.1 29.0 237.8 181.9 644.6 64.5 99.6 2.9 17.7 37.8 28.7 7.2 69.8 20.2 10.4 54.8 222.3 54.4 33.2 153.0 47.0 129.1 17.4 35.2 7.2 54.1 9.5 95.4 23.3 39.1 78.0 88.3 38.8 17.7 17.9 9.6 16.9 0.0 5.6 34.3 38.7 20.3 65.9 14.7 5.9 60.9 35.6 34.7 42.1 7.9 221.4 39.2 3.7 89.4 73.0 2.6 81.2 192.6 23.8 13.2 42.4 26.3 6.6 39.4 51.3 75.8 36.1 42.3 136.1 66.8 273.7 27.0 18.0 326.1 STK17B DRAK2 ENSG00000081320 "Serine/threonine kinase 17b" O94768 2 196133583-196176503 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "bone marrow: 376.2;lymphoid tissue: 113.3" "Cell type enhanced" "Detected in many" "B-cells: 229.3;dendritic cells: 267.7;granulocytes: 195.1;Langerhans cells: 201.3;Macrophages: 198.9;Plasma cells: 191.8;T-cells: 342.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Daudi: 122.3;HMC-1: 118.9;Karpas-707: 111.6;U-698: 132.1" "Region enriched" "Detected in all" 5 "cerebellum: 63.4" "Low region specificity" "Detected in all" HPA034858 Enhanced Uncertain "Plasma membrane,Cytosol" NA Yes "Cluster 5: Granulocytes - Unknown function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 24: Non-specific - Transcription regulation" "Plasma membrane, Cytosol" "HPA034858: AB_10670981" "unprognostic (2.14e-1)" "unprognostic (2.45e-3)" "unprognostic (3.68e-2)" "unprognostic (3.61e-2)" "unprognostic (3.63e-2)" "unprognostic (7.43e-3)" "unprognostic (1.75e-1)" "unprognostic (7.63e-2)" "unprognostic (9.15e-2)" "unprognostic (1.14e-1)" "unprognostic (9.90e-2)" "unprognostic (1.52e-1)" "prognostic unfavorable (5.72e-8)" "unprognostic (1.88e-1)" "unprognostic (1.19e-2)" "unprognostic (2.64e-2)" "unprognostic (5.80e-2)" 28.2 8.9 2.1 67.0 2.9 376.2 21.5 3.7 5.3 24.2 3.3 19.1 27.8 5.4 1.8 11.9 5.8 20.4 4.6 4.1 3.3 6.5 8.5 23.6 113.3 3.1 2.0 2.2 12.7 2.1 3.0 16.7 3.2 10.5 17.5 0.4 17.0 5.7 2.4 11.2 40.1 16.8 2.2 56.9 20.1 9.5 4.0 60.9 7.2 3.5 111.1 24.4 5.2 2.9 11.0 7.5 11.2 4.2 47.7 18.1 12.4 25.7 38.4 27.7 28.5 22.8 3.9 122.3 23.1 14.8 7.3 7.4 4.7 11.1 33.4 21.8 12.7 11.6 9.1 2.2 14.2 47.0 118.9 23.1 10.9 34.3 17.7 39.2 11.5 28.5 9.1 111.6 69.4 5.9 61.6 106.0 6.3 19.9 17.2 10.1 67.5 37.4 16.3 25.6 4.2 4.2 6.6 6.4 5.4 17.2 4.3 24.3 14.0 26.8 13.1 19.3 14.7 45.5 78.9 132.1 20.2 15.9 12.1 165.1 74.3 163.1 43.7 81.3 55.4 49.2 77.0 52.8 53.0 58.6 98.6 82.4 236.7 40.8 113.1 37.7 73.8 89.3 2.1 2.9 3.7 5.3 4.1 3.3 3.1 2.0 3.2 2.2 4.0 2.9 23.3 89.8 74.0 48.3 229.3 59.9 27.1 15.1 10.8 0.9 28.9 15.2 2.6 12.8 42.5 11.0 0.0 7.9 267.7 54.0 3.9 6.6 6.8 15.3 14.1 11.3 3.0 68.8 3.4 2.8 24.0 27.2 38.2 26.5 195.1 47.4 5.3 2.4 26.1 0.0 3.1 13.9 18.3 151.1 201.3 3.6 5.6 198.9 58.7 11.2 158.0 0.6 118.4 17.6 0.7 10.9 41.6 4.5 191.8 34.3 80.7 2.5 26.9 0.3 6.6 49.7 19.7 41.1 26.3 16.4 63.4 5.1 342.5 22.6 13.2 53.8 STK19 "D6S60, G11, RP1" ENSG00000204344 "Serine/threonine kinase 19" P49842 6 31971091-31982821 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in all" 4 "Proximal tubular cells: 348.9" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "HDLM-2: 1.4;HEL: 1.5;HL-60: 1.6;REH: 1.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031511, HPA068559" Uncertain Supported "Nuclear speckles" NA NA "Cluster 30: Non-specific - Translation" "Cluster 72: Non-specific - Transcription" "Cluster 36: HEL - Hemostasis" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nuclear speckles" "HPA031511: AB_2673915, HPA068559: AB_2686004" "unprognostic (1.65e-1)" "unprognostic (2.30e-1)" "unprognostic (3.31e-1)" "unprognostic (1.86e-1)" "unprognostic (2.63e-1)" "unprognostic (1.67e-1)" "unprognostic (1.15e-2)" "unprognostic (4.26e-2)" "prognostic unfavorable (1.18e-4)" "unprognostic (3.95e-2)" "unprognostic (2.76e-3)" "unprognostic (2.25e-2)" "unprognostic (1.08e-2)" "unprognostic (1.02e-1)" "unprognostic (1.60e-1)" "unprognostic (2.40e-1)" "unprognostic (4.10e-1)" 1.5 3.6 0.1 0.2 0.1 0.0 1.3 0.4 0.9 2.1 0.0 2.5 0.0 1.4 0.3 1.9 1.0 0.1 1.2 0.0 0.0 1.5 2.2 1.3 0.0 0.0 0.0 1.1 1.1 0.2 1.4 0.4 0.1 2.1 0.0 0.2 0.9 0.1 1.3 2.5 0.7 0.0 0.0 1.2 1.3 1.5 0.1 0.1 1.2 0.0 0.1 2.0 1.5 0.4 0.0 0.1 0.0 0.4 1.1 0.7 0.0 0.3 0.1 0.2 0.4 0.0 0.7 0.6 0.3 0.5 0.0 0.6 0.0 0.2 0.3 1.4 0.4 1.5 0.3 0.0 0.5 1.6 0.0 0.6 0.0 0.3 0.1 0.4 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.7 1.1 0.4 0.0 0.0 0.1 0.3 0.1 0.3 0.0 0.0 0.7 0.0 0.0 0.0 0.4 0.4 0.0 0.0 0.9 0.0 0.7 0.2 0.0 0.0 1.1 0.0 0.1 0.3 0.2 0.6 0.2 0.0 0.8 0.2 0.3 0.1 0.1 0.3 0.4 0.4 0.0 0.1 0.1 0.1 0.4 0.9 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.4 21.2 9.6 21.5 13.7 16.4 13.0 14.0 23.0 13.6 11.8 26.6 27.6 8.1 18.6 24.6 22.0 20.9 37.2 22.4 13.8 39.2 26.3 85.8 27.8 31.8 20.6 19.3 4.6 8.7 28.3 20.0 23.3 19.4 20.7 9.5 20.1 14.3 21.1 19.3 10.1 8.0 17.3 18.3 8.8 10.0 76.0 20.2 18.3 17.8 11.2 12.5 30.2 13.4 4.5 6.5 23.6 16.4 18.4 11.9 13.2 15.0 348.9 41.8 21.9 32.9 19.6 21.1 39.5 21.0 17.9 18.2 49.7 19.8 45.1 13.1 11.8 STK24 "MST-3, MST3, MST3B, STE20, STK3" ENSG00000102572 "Serine/threonine kinase 24" Q9Y6E0 13 98445185-98577940 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 203.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026435, HPA026502" Enhanced Supported Nucleoli,Cytosol No No 1100000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoli, Cytosol" "HPA026435: AB_1854151, HPA026502: AB_1854152" "unprognostic (3.49e-2)" "unprognostic (2.39e-2)" "unprognostic (1.78e-1)" "unprognostic (3.44e-2)" "unprognostic (2.86e-1)" "unprognostic (3.25e-2)" "unprognostic (9.67e-3)" "prognostic unfavorable (6.23e-6)" "unprognostic (5.45e-2)" "unprognostic (1.13e-1)" "prognostic unfavorable (5.81e-4)" "unprognostic (9.62e-2)" "prognostic favorable (6.91e-5)" "unprognostic (3.10e-2)" "unprognostic (4.49e-2)" "unprognostic (3.88e-2)" "unprognostic (1.12e-2)" 71.4 32.4 30.9 49.0 32.6 58.0 60.9 34.3 34.4 99.1 49.4 75.1 83.0 53.9 58.4 167.9 50.7 55.8 49.1 34.2 29.0 77.0 32.4 54.1 67.0 29.0 35.5 44.2 48.0 42.4 31.1 57.5 27.2 49.6 72.3 31.7 70.4 51.2 47.1 154.4 94.4 48.2 28.5 51.5 78.3 36.9 41.3 68.2 55.0 38.8 74.1 86.6 113.9 29.2 161.8 49.4 85.6 79.8 128.6 76.4 121.3 73.8 103.0 100.9 97.7 145.7 212.6 114.1 36.6 92.8 63.1 142.1 80.2 162.3 95.5 286.3 41.2 122.0 59.8 84.2 181.0 124.4 82.8 49.8 253.7 79.3 231.6 106.2 88.2 88.0 45.2 76.6 67.0 70.3 93.5 51.1 76.9 217.3 36.6 116.5 52.5 62.3 98.1 143.2 49.8 71.4 46.7 74.2 103.0 129.7 89.6 119.1 120.0 63.8 46.3 52.8 86.5 74.1 41.7 42.5 99.3 74.0 107.4 5.7 12.7 6.3 5.5 10.9 6.6 6.1 10.2 8.0 10.9 7.9 6.9 5.6 10.9 1.5 13.5 7.1 13.7 6.7 30.9 32.6 34.3 34.4 34.2 29.0 29.0 35.5 27.2 28.5 41.3 29.2 36.2 12.8 27.4 27.7 37.4 70.9 83.6 51.2 20.5 20.3 41.5 33.5 3.0 55.8 55.8 68.0 56.3 39.2 36.9 203.8 25.4 35.8 3.5 74.2 48.7 32.5 42.6 41.4 39.2 55.0 45.9 43.2 65.7 99.6 18.4 49.1 25.0 26.6 28.0 10.1 34.2 86.0 24.4 82.2 57.9 5.9 26.8 58.4 56.9 49.6 47.6 25.5 20.6 35.7 11.1 84.4 96.5 30.5 25.5 60.4 111.8 39.2 51.6 11.0 39.5 47.7 41.0 2.9 21.2 61.9 82.1 20.0 45.5 20.4 59.1 153.3 STK25 "SOK1, YSK1" ENSG00000115694 "Serine/threonine kinase 25" O00506 2 241492670-241509730 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 5 "skeletal muscle: 489.9;tongue: 213.8" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA047147 Uncertain NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "HPA047147: AB_10966137" "unprognostic (1.75e-1)" "unprognostic (8.29e-2)" "prognostic unfavorable (6.03e-4)" "unprognostic (3.42e-2)" "unprognostic (2.71e-1)" "unprognostic (1.24e-1)" "prognostic unfavorable (3.91e-8)" "unprognostic (6.16e-2)" "unprognostic (7.15e-3)" "unprognostic (1.11e-1)" "unprognostic (2.58e-3)" "unprognostic (1.55e-1)" "unprognostic (2.47e-2)" "unprognostic (2.00e-1)" "unprognostic (1.37e-1)" "unprognostic (3.19e-1)" "unprognostic (4.58e-1)" 53.2 50.6 48.2 37.1 48.9 47.0 52.8 35.8 56.7 59.8 27.8 59.8 36.2 62.9 24.0 62.6 60.5 32.9 69.1 50.4 47.1 56.5 50.0 49.6 36.7 37.5 40.9 59.4 70.3 45.9 65.3 38.7 43.3 55.4 30.5 28.9 48.7 40.2 489.9 53.1 50.5 42.1 30.7 61.6 58.7 48.7 46.4 38.5 71.9 213.8 31.8 60.8 56.7 41.2 75.2 46.9 91.1 114.0 109.9 75.9 140.1 122.3 81.8 90.9 103.4 52.3 64.4 28.5 33.7 163.9 82.3 62.9 130.2 132.9 109.9 107.0 136.4 79.7 98.3 136.6 99.3 48.7 59.0 110.1 93.9 88.3 70.3 111.1 208.7 102.6 125.2 24.6 168.8 78.6 73.0 75.9 127.9 69.5 66.3 121.1 116.2 42.6 79.5 62.4 152.8 70.2 59.4 44.2 77.0 102.7 35.7 85.2 245.7 68.2 83.0 79.1 88.3 50.3 12.1 48.8 66.0 39.6 79.1 17.0 16.3 12.9 17.3 15.5 16.3 15.9 15.9 18.5 15.0 16.9 12.3 11.8 5.8 24.6 19.7 11.8 23.3 12.6 48.2 48.9 35.8 56.7 50.4 47.1 37.5 40.9 43.3 30.7 46.4 41.2 43.6 22.4 41.4 23.2 19.7 25.5 29.0 29.7 19.9 48.7 33.2 39.4 36.3 42.9 24.0 25.8 27.1 82.7 19.8 35.2 27.4 46.0 13.8 18.5 28.4 52.7 35.4 48.6 29.8 34.2 80.7 35.1 36.7 25.4 25.4 40.8 45.7 21.5 45.1 32.0 26.1 40.0 20.3 27.3 25.7 14.4 32.6 20.8 19.6 21.5 47.0 58.9 18.6 16.1 27.5 36.9 74.5 39.9 15.8 37.1 43.4 46.1 16.2 41.1 46.0 41.7 35.3 90.2 54.7 31.7 30.4 52.4 25.4 53.2 44.9 29.9 STK26 "MASK, MST4" ENSG00000134602 "Serine/threonine kinase 26" Q9P289 X 132023302-132075943 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 70.0;epididymis: 56.3" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 55.2;dendritic cells: 42.7;NK-cells: 53.5;Syncytiotrophoblasts: 59.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "MOLT-4: 140.1;U-937: 144.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA059921 Approved Uncertain "Nucleoplasm,Golgi apparatus,Centrosome,Cytosol" Yes No 360000 "Cluster 46: Basophils - DNA binding" "Cluster 34: Non-specific - Transcription" "Cluster 32: U-937 - Innate immune response" "Cluster 47: Cytotrophoblasts - Unknown function" Nucleoplasm "Golgi apparatus, Centrosome, Cytosol" "HPA059921: AB_2684163" "unprognostic (6.53e-2)" "unprognostic (7.83e-2)" "unprognostic (1.77e-1)" "unprognostic (1.02e-3)" "unprognostic (4.42e-1)" "unprognostic (1.03e-2)" "prognostic unfavorable (6.82e-4)" "unprognostic (1.18e-1)" "unprognostic (1.93e-1)" "unprognostic (1.31e-1)" "unprognostic (1.42e-3)" "unprognostic (2.49e-1)" "prognostic unfavorable (6.87e-5)" "unprognostic (4.76e-2)" "unprognostic (1.83e-1)" "unprognostic (1.77e-1)" "unprognostic (2.88e-1)" 6.0 2.5 1.0 15.2 2.7 70.0 6.0 1.7 1.3 6.8 2.5 11.5 9.6 46.6 56.3 13.1 7.4 5.6 1.4 0.7 1.5 3.5 5.2 7.2 26.2 0.8 0.8 2.1 3.7 23.5 5.0 25.2 0.7 20.0 11.6 0.2 7.3 35.8 0.9 7.8 6.9 38.1 0.6 13.2 12.2 2.2 3.8 41.3 3.7 1.2 23.5 11.8 7.4 0.7 32.9 11.3 1.3 0.0 5.2 4.9 72.0 1.0 4.0 0.5 0.6 30.1 29.0 44.6 19.4 7.3 22.1 36.5 80.8 51.1 0.0 39.1 66.6 64.6 25.9 28.4 4.7 135.3 5.1 6.9 30.0 0.1 33.7 15.1 14.2 60.0 29.2 40.4 12.2 29.0 140.1 124.9 64.4 22.0 4.3 99.9 39.7 57.9 32.6 51.8 26.6 29.6 19.2 17.0 0.9 54.9 22.0 35.4 0.3 12.8 13.7 39.0 47.9 31.0 52.0 49.8 11.7 144.8 6.5 59.1 9.5 31.6 22.8 12.4 22.4 14.5 15.2 19.6 11.3 12.6 19.7 20.6 18.2 41.0 22.7 4.2 7.2 20.4 1.0 2.7 1.7 1.3 0.7 1.5 0.8 0.8 0.7 0.6 3.8 0.7 0.9 22.4 15.6 0.0 24.7 0.0 36.4 0.0 6.8 0.0 5.9 10.9 1.3 5.7 8.1 11.0 0.0 55.2 42.7 6.5 3.9 4.5 0.6 7.4 1.8 1.7 1.2 12.8 2.0 7.1 34.7 9.6 15.3 17.9 11.4 0.5 1.4 4.4 11.8 0.0 1.4 4.8 0.0 8.8 0.0 0.4 3.4 17.3 0.0 2.8 13.5 0.0 53.5 0.0 0.2 10.9 4.0 2.2 14.5 33.6 1.9 1.5 6.6 0.0 6.6 6.7 3.6 1.8 2.5 16.1 0.0 59.1 27.4 0.6 6.5 18.2 STK3 "KRS1, MST2" ENSG00000104375 "Serine/threonine kinase 3" Q13188 8 98371228-98942827 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Microglial cells: 152.7;Oligodendrocytes: 189.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in all" 4 "dendritic cells: 7.9;granulocytes: 8.8;monocytes: 8.5" "Cell line enhanced" "Detected in many" "A-431: 85.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007120, CAB025316" Uncertain Approved "Intermediate filaments,Rods & Rings" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 64: Astrocytes - Nervous system maintenance" "Intermediate filaments, Rods & Rings" "CAB025316: , HPA007120: AB_10601664" "unprognostic (7.88e-3)" "unprognostic (1.96e-1)" "unprognostic (6.57e-2)" "prognostic unfavorable (1.53e-4)" "unprognostic (2.95e-1)" "unprognostic (1.12e-3)" "unprognostic (9.68e-3)" "prognostic unfavorable (4.25e-4)" "unprognostic (6.71e-2)" "unprognostic (9.83e-2)" "prognostic unfavorable (9.21e-5)" "unprognostic (9.16e-2)" "unprognostic (1.03e-1)" "unprognostic (2.27e-1)" "unprognostic (1.29e-1)" "unprognostic (5.86e-2)" "unprognostic (9.72e-2)" 15.1 14.4 5.6 7.9 7.0 3.5 14.1 6.6 7.4 17.4 7.2 13.1 5.5 24.9 14.3 10.2 17.0 14.2 9.1 5.1 6.3 15.6 14.3 11.1 5.5 7.7 6.7 25.0 10.0 16.1 6.4 18.5 7.4 16.5 6.7 12.0 10.7 17.6 11.4 9.6 8.3 17.2 6.3 6.8 8.5 11.4 7.1 5.1 11.9 8.6 5.5 13.6 13.7 7.9 85.3 15.7 16.2 22.0 51.2 25.4 16.4 28.8 25.6 26.3 22.8 11.7 35.7 0.0 25.6 28.7 14.1 33.4 11.4 24.8 42.2 20.5 14.8 22.9 7.2 8.0 17.5 7.7 19.0 17.0 41.9 13.5 36.6 17.2 11.5 13.4 9.8 12.2 19.4 10.7 19.3 9.4 4.9 58.0 6.1 17.1 14.1 7.5 29.9 10.7 4.3 9.6 18.4 21.1 18.2 21.0 17.8 12.3 8.7 17.9 11.5 27.1 16.3 9.8 15.5 6.2 15.9 9.5 29.0 2.0 8.3 4.6 1.3 8.5 1.4 1.8 0.7 1.8 7.9 1.1 1.0 0.6 8.8 2.0 5.4 3.3 0.1 2.8 5.6 7.0 6.6 7.4 5.1 6.3 7.7 6.7 7.4 6.3 7.1 7.9 25.9 38.5 37.4 132.9 6.0 43.7 44.8 25.3 23.3 6.9 29.0 15.5 16.6 31.5 37.7 29.5 14.6 43.6 2.5 11.7 23.5 21.5 118.3 23.7 65.8 31.3 9.1 16.2 34.3 18.9 56.1 39.8 9.7 28.9 17.1 13.3 24.3 23.7 19.2 10.1 33.5 7.8 26.4 17.0 25.1 77.1 91.0 18.6 24.9 152.7 13.8 15.0 3.1 60.3 189.9 24.9 13.1 74.1 6.2 42.1 32.3 25.0 29.0 15.6 39.5 43.8 39.7 16.7 12.6 12.3 40.5 64.7 5.9 47.0 13.8 36.0 STK31 "SgK396, TDRD8" ENSG00000196335 "Serine/threonine kinase 31" Q9BXU1 7 23710203-23832513 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 57 "testis: 64.0" "Group enriched" "Detected in some" 5 "Spermatocytes: 161.5;Spermatogonia: 75.0" "Cancer enhanced" "Detected in some" "testis cancer: 2.1" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 9 "CACO-2: 20.5" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA023194, HPA072896" Enhanced NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 39: CACO-2 - Unknown function" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA023194: AB_1857590, HPA072896: " "unprognostic (4.25e-2)" "unprognostic (1.04e-1)" "unprognostic (3.98e-2)" "unprognostic (5.41e-2)" "unprognostic (1.62e-1)" "unprognostic (1.50e-2)" "unprognostic (1.09e-2)" "unprognostic (1.26e-1)" "unprognostic (1.34e-1)" "unprognostic (1.73e-1)" "unprognostic (2.42e-3)" "unprognostic (2.92e-1)" "unprognostic (1.29e-6)" "unprognostic (7.83e-2)" "unprognostic (9.21e-3)" "unprognostic (1.46e-1)" "unprognostic (3.65e-1)" 0.1 0.1 0.3 0.0 0.4 0.0 0.2 1.1 0.4 0.1 0.2 0.2 0.3 0.1 0.0 0.3 0.2 0.1 0.1 0.3 0.4 0.3 0.3 0.4 0.0 0.6 0.4 0.2 0.4 0.0 0.1 0.0 0.7 0.2 0.0 0.2 0.2 0.0 0.0 0.2 0.3 0.0 0.3 0.2 0.4 64.0 0.4 0.1 0.2 0.0 0.0 0.1 0.1 0.6 0.2 0.7 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 20.5 2.3 0.0 2.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 1.1 0.4 0.3 0.4 0.6 0.4 0.7 0.3 0.4 0.6 0.4 3.2 1.1 2.9 0.3 0.1 0.2 0.5 0.0 2.0 1.0 0.1 0.6 1.5 2.8 0.0 0.0 0.6 0.1 0.3 0.0 0.2 21.1 0.6 0.0 0.4 1.2 0.0 2.9 0.6 0.1 0.6 2.0 0.2 0.0 0.3 0.0 0.5 0.2 0.0 4.6 0.4 2.0 0.0 0.0 19.6 3.4 0.5 0.0 2.8 0.0 1.0 0.0 2.5 12.7 0.4 5.3 3.0 0.5 0.3 0.8 0.1 4.3 1.2 0.0 0.6 0.1 161.5 75.0 0.0 0.1 0.5 0.5 0.1 0.5 0.5 STK32A "MGC22688, YANK1" ENSG00000169302 "Serine/threonine kinase 32A" Q8WU08 5 147234963-147387855 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 11.2;brain: 24.4" "Cell type enriched" "Detected in many" 19 "Oligodendrocyte precursor cells: 306.6" "Group enriched" "Detected in many" 5 "glioma: 4.3;melanoma: 11.9;thyroid cancer: 9.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "RT4: 13.6;SK-MEL-30: 48.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040236 Approved Centrosome NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 68: Oligodendrocytes - Mixed function" Centrosome "HPA040236: AB_10795416" "unprognostic (1.90e-1)" "unprognostic (4.71e-4)" "unprognostic (5.32e-2)" "unprognostic (3.49e-2)" "unprognostic (7.62e-2)" "unprognostic (6.82e-2)" "unprognostic (2.66e-2)" "unprognostic (2.96e-3)" "unprognostic (4.85e-2)" "unprognostic (2.36e-2)" "unprognostic (3.87e-1)" "unprognostic (8.38e-2)" "unprognostic (2.50e-3)" "unprognostic (5.53e-5)" "unprognostic (2.48e-1)" "unprognostic (3.20e-2)" "unprognostic (3.67e-3)" 1.3 11.2 5.9 0.6 9.5 0.0 1.2 13.2 3.1 1.0 1.0 2.3 0.5 0.5 2.6 0.3 0.8 1.5 1.0 3.5 14.4 3.4 0.1 1.2 0.0 11.7 24.4 2.5 2.6 0.1 8.1 0.1 17.0 1.0 0.3 2.6 0.9 0.8 0.2 3.7 0.7 0.4 10.4 0.3 1.2 1.0 14.0 0.1 8.7 0.5 0.0 1.7 1.0 10.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.5 0.0 1.4 0.0 0.0 0.0 0.1 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.1 0.0 0.0 0.0 6.5 0.0 0.0 0.0 0.0 0.5 0.0 1.1 0.0 0.0 0.2 4.4 13.6 1.2 0.5 0.0 0.0 48.6 0.2 0.0 0.0 0.1 0.0 0.5 0.7 0.4 1.0 0.2 0.0 1.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.9 9.5 13.2 3.1 3.5 14.4 11.7 24.4 17.0 10.4 14.0 10.1 0.2 0.0 2.6 8.5 0.0 1.5 0.2 1.4 0.0 1.8 1.3 0.5 0.5 0.0 1.0 1.8 0.0 0.0 0.0 0.1 1.9 1.8 6.9 0.2 0.5 0.1 0.0 0.0 4.6 2.7 0.0 2.7 0.0 0.7 0.0 4.2 0.0 0.0 0.1 0.0 5.2 0.0 2.0 0.0 1.0 10.5 0.9 0.2 16.0 0.0 0.0 4.0 0.0 306.6 0.7 5.5 0.0 4.1 0.0 0.3 0.0 4.1 0.2 1.0 0.0 5.4 0.5 0.0 0.1 0.0 0.3 0.1 0.1 1.4 0.0 0.6 STK32B "HSA250839, STK32, STKG6, YANK2" ENSG00000152953 "Serine/threonine kinase 32B" Q9NY57 4 5051480-5500994 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 15.0;lymphoid tissue: 19.5" "Cell type enhanced" "Detected in many" "Early spermatids: 108.2;Late spermatids: 39.3;Microglial cells: 27.2;Oligodendrocyte precursor cells: 169.4" "Cancer enhanced" "Detected in many" "renal cancer: 6.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "GAMG: 27.5;HUVEC TERT2: 27.5;REH: 25.2;U-2197: 43.8;WM-115: 112.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA015820 Approved "Nucleoplasm,Nuclear bodies,Cytosol" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 3: T-cells - Adaptive immune response" "Cluster 17: WM-115 - Nervous system development" "Cluster 68: Oligodendrocytes - Mixed function" "Nucleoplasm, Nuclear bodies" Cytosol "HPA015820: AB_1858913" "unprognostic (4.48e-2)" "unprognostic (1.02e-1)" "unprognostic (6.08e-2)" "unprognostic (1.35e-1)" "unprognostic (8.12e-3)" "unprognostic (9.96e-2)" "unprognostic (1.64e-4)" "unprognostic (1.27e-1)" "unprognostic (1.27e-1)" "unprognostic (1.70e-1)" "unprognostic (2.54e-1)" "unprognostic (8.82e-2)" "prognostic favorable (1.63e-8)" "unprognostic (8.10e-3)" "unprognostic (5.04e-2)" "unprognostic (3.62e-2)" "unprognostic (1.67e-3)" 3.5 0.3 2.3 1.2 7.8 1.5 4.3 1.9 2.3 3.3 1.5 1.1 0.5 3.5 0.3 1.2 1.3 1.4 0.4 2.1 4.5 15.0 0.1 0.9 1.8 3.7 3.9 0.6 1.8 0.3 0.4 3.2 3.7 0.6 1.1 0.8 1.0 0.9 1.3 2.4 1.1 2.5 3.6 0.2 6.0 4.5 3.5 19.5 1.7 1.7 1.0 3.1 1.5 3.6 0.0 14.0 0.8 0.0 0.6 1.0 0.0 9.7 1.1 6.3 0.2 0.1 0.0 0.0 2.1 19.7 27.5 0.1 1.5 0.0 2.3 0.0 0.0 0.1 6.4 0.0 0.0 0.0 0.0 0.0 0.0 5.0 0.2 0.2 27.5 1.4 0.0 0.1 3.4 0.0 0.0 2.0 4.1 0.0 0.0 25.2 0.1 0.0 6.2 0.0 0.4 0.0 0.0 0.1 8.5 0.6 0.0 0.0 7.1 0.2 2.8 43.8 0.0 0.9 0.1 0.0 0.1 0.0 112.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 2.3 7.8 1.9 2.3 2.1 4.5 3.7 3.9 3.7 3.6 3.5 3.6 3.6 0.0 1.1 1.6 0.0 2.3 0.2 0.0 0.0 0.0 4.2 1.7 0.4 0.0 0.0 0.0 0.0 0.0 1.5 0.0 17.6 1.1 108.2 0.2 0.1 3.2 0.0 0.0 3.7 0.0 0.1 5.5 4.1 0.3 0.0 0.0 0.0 0.0 1.7 0.0 14.4 0.0 0.0 0.0 1.2 39.3 1.5 1.1 5.4 27.2 0.5 0.0 0.0 169.4 1.3 0.4 0.0 1.2 0.0 0.1 0.0 18.9 0.0 0.0 0.0 0.6 0.4 1.2 5.5 0.0 1.0 0.0 0.2 0.4 0.0 0.1 STK32C "MGC23665, PKE, YANK3" ENSG00000165752 "Serine/threonine kinase 32C" Q86UX6 10 132207492-132331847 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 54.1" "Group enriched" "Detected in many" 4 "Early spermatids: 278.9;Late spermatids: 83.3;Spermatocytes: 89.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 55.3" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017894 Uncertain NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 78: Testis - Spermatogenesis" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 29: Early spermatids - Spermatogenesis" "HPA017894: AB_1857591" "unprognostic (2.11e-1)" "unprognostic (8.40e-2)" "unprognostic (4.80e-3)" "prognostic unfavorable (1.09e-4)" "unprognostic (1.65e-2)" "unprognostic (5.52e-2)" "prognostic unfavorable (1.68e-6)" "unprognostic (2.03e-1)" "unprognostic (7.79e-2)" "unprognostic (2.14e-1)" "unprognostic (1.18e-2)" "unprognostic (1.13e-1)" "prognostic unfavorable (5.31e-6)" "unprognostic (8.65e-2)" "unprognostic (3.20e-1)" "unprognostic (5.05e-2)" "unprognostic (1.36e-1)" 11.0 12.5 31.4 7.1 39.6 7.6 8.9 17.8 37.5 8.1 13.5 9.1 5.2 6.9 14.8 5.4 9.4 6.5 7.4 31.3 23.2 15.6 5.0 8.8 10.0 24.6 26.1 6.7 7.4 6.0 12.3 4.9 20.5 6.6 4.7 7.9 5.7 5.2 13.7 7.6 6.8 5.0 23.4 15.1 6.2 54.1 30.9 10.8 6.4 9.1 6.4 8.3 6.5 25.9 69.4 43.5 13.3 33.5 18.4 23.3 2.7 14.1 10.7 17.4 22.2 10.0 46.0 14.8 10.3 16.4 22.0 14.9 18.6 5.5 16.9 8.9 31.1 8.9 46.1 47.1 22.9 7.9 31.1 17.6 20.8 15.7 17.3 22.0 15.6 25.1 15.4 10.2 19.0 21.1 10.4 30.4 8.8 12.6 31.4 12.2 8.2 4.9 23.3 11.7 34.6 27.3 10.2 9.3 20.9 7.9 10.5 19.2 10.6 13.6 14.2 18.2 11.3 19.1 3.8 38.7 31.4 7.4 7.1 55.3 17.9 16.5 5.8 19.6 7.3 6.2 4.7 6.6 25.1 10.2 5.8 4.5 2.4 6.1 17.3 14.5 9.2 7.0 31.4 39.6 17.8 37.5 31.3 23.2 24.6 26.1 20.5 23.4 30.9 25.9 6.6 0.0 7.2 13.4 7.3 5.2 6.8 5.7 4.6 8.4 10.3 11.0 3.7 2.8 6.1 12.9 12.5 3.4 9.3 3.2 19.6 5.4 278.9 25.9 8.2 8.2 19.2 15.8 22.9 8.7 2.3 7.2 6.6 11.8 15.8 6.0 13.6 5.5 14.6 37.0 13.9 7.4 12.2 24.3 28.5 83.3 9.0 14.8 12.4 7.5 14.0 11.0 6.2 9.5 10.0 6.0 5.1 6.8 4.8 11.4 3.8 13.2 13.7 14.6 6.6 10.5 5.6 89.8 20.0 5.9 5.1 1.5 9.3 10.1 7.6 7.3 STK33 ENSG00000130413 "Serine/threonine kinase 33" Q9BYT3 11 8391868-8594289 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 49.3;testis: 51.8" "Cell type enhanced" "Detected in many" "Astrocytes: 213.8;Early spermatids: 98.8;Endometrial ciliated cells: 220.9;Late spermatids: 157.0;Oligodendrocyte precursor cells: 117.6;Respiratory ciliated cells: 155.3;Spermatocytes: 148.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "memory B-cell: 4.1;naive B-cell: 2.2" "Lineage enriched" "Detected in single" 5 "B-cells: 4.1" "Cell line enhanced" "Detected in many" "Daudi: 23.0;hTERT-RPE1: 22.0;Karpas-707: 21.2;SCLC-21H: 22.9;U-251 MG: 24.3;U-266/84: 21.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA015742, HPA056855" Uncertain Approved Nucleoplasm,Nucleoli,Cytosol NA NA "Cluster 37: B-cells - Transcription" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 49: Ciliated cells - Cilium organization" Nucleoplasm "Nucleoli, Cytosol" "HPA015742: AB_1857592, HPA056855: AB_2683257" "unprognostic (2.57e-2)" "unprognostic (2.80e-1)" "unprognostic (2.23e-3)" "unprognostic (2.76e-3)" "unprognostic (3.57e-1)" "unprognostic (1.40e-1)" "unprognostic (7.28e-2)" "unprognostic (3.85e-4)" "unprognostic (1.23e-1)" "unprognostic (8.06e-2)" "unprognostic (1.33e-3)" "unprognostic (9.46e-2)" "prognostic favorable (4.89e-6)" "unprognostic (2.39e-2)" "unprognostic (1.37e-1)" "unprognostic (3.49e-2)" "unprognostic (2.90e-2)" 1.3 8.1 6.7 2.0 6.6 1.3 0.5 8.5 4.9 5.6 49.3 8.3 3.3 12.0 11.3 2.7 42.3 5.1 16.2 6.1 10.1 10.2 0.4 7.1 2.0 14.7 15.6 13.4 6.5 23.1 24.1 0.1 13.3 6.4 1.5 15.6 2.1 11.5 3.9 0.2 3.4 9.3 12.0 1.5 6.0 51.8 12.8 3.8 20.0 6.0 2.2 3.4 1.7 8.3 0.0 3.4 15.4 0.0 0.0 0.0 0.0 3.0 3.1 7.0 6.2 2.2 0.0 23.0 11.5 0.6 8.7 0.0 6.9 2.5 6.0 0.0 18.9 0.0 4.2 5.6 2.5 13.4 0.0 1.1 0.0 0.2 0.0 22.0 0.5 11.2 0.0 21.2 0.3 0.0 0.4 0.0 11.2 0.0 0.0 8.8 2.2 14.3 6.1 0.0 22.9 6.2 0.0 0.0 0.1 4.3 0.0 1.3 0.0 0.0 10.6 0.2 24.3 5.1 21.2 0.3 6.8 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 4.1 0.0 0.7 0.0 2.2 0.0 0.6 0.0 0.1 0.0 0.4 0.1 0.2 6.7 6.6 8.5 4.9 6.1 10.1 14.7 15.6 13.3 12.0 12.8 8.3 0.1 19.2 14.5 213.8 6.2 0.0 1.3 1.9 0.0 20.7 0.1 0.3 37.8 8.6 27.5 20.2 70.9 0.1 1.4 0.2 3.9 9.5 98.8 220.9 5.5 1.8 9.1 1.7 12.0 4.9 3.3 5.0 6.1 17.8 1.3 29.3 0.4 0.0 0.3 1.7 15.4 1.6 6.1 0.0 0.0 157.0 4.4 0.6 0.0 23.4 0.0 31.0 0.0 117.6 19.7 4.4 0.4 17.0 5.2 0.5 3.6 13.5 155.3 77.4 0.0 0.2 2.7 148.3 26.8 0.2 0.0 0.0 1.3 6.3 3.5 0.0 STK35 "bA550O8.2, CLIK1" ENSG00000125834 "Serine/threonine kinase 35" Q8TDR2 20 2101827-2177038 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 6 "retina: 118.8" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 150.1;Early spermatids: 214.3;Horizontal cells: 294.4;Late spermatids: 821.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026452, HPA051673" Approved Supported "Nucleoplasm,Nuclear bodies" NA NA "Cluster 30: Non-specific - Translation" "Cluster 77: Retina - Visual perception" "Cluster 39: CACO-2 - Unknown function" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Nuclear bodies" "HPA026452: AB_2671861, HPA051673: AB_2681569" "unprognostic (2.25e-2)" "unprognostic (2.97e-1)" "unprognostic (2.87e-2)" "unprognostic (1.30e-2)" "unprognostic (3.25e-1)" "unprognostic (2.28e-1)" "prognostic unfavorable (9.46e-6)" "unprognostic (6.53e-2)" "unprognostic (1.82e-1)" "unprognostic (3.05e-2)" "unprognostic (1.37e-1)" "unprognostic (2.07e-1)" "unprognostic (4.39e-2)" "unprognostic (1.74e-1)" "unprognostic (4.67e-1)" "unprognostic (1.40e-1)" "unprognostic (4.99e-2)" 9.0 11.3 9.4 6.6 8.3 8.6 7.9 6.7 13.0 7.3 5.1 10.2 7.1 9.7 5.8 15.6 8.6 7.1 10.0 9.5 8.3 6.9 8.9 8.5 6.4 6.2 10.6 8.0 9.3 7.8 9.7 6.2 7.3 8.0 8.2 118.8 8.7 6.3 6.5 11.3 9.3 7.8 5.0 8.3 8.7 18.3 15.4 6.4 8.5 5.7 7.6 8.1 8.9 8.6 23.3 19.4 14.7 25.4 6.7 9.1 17.9 9.3 11.4 12.2 12.5 25.6 17.5 15.9 7.5 11.7 19.0 34.1 17.6 21.4 13.8 6.3 8.4 15.2 7.4 28.1 8.5 13.7 6.8 7.9 18.5 19.5 16.7 11.2 11.7 15.0 14.9 12.8 8.0 10.3 17.4 19.4 27.5 18.4 12.9 14.9 13.2 10.1 11.1 22.9 24.3 11.8 16.6 29.3 15.0 17.0 14.5 13.5 10.0 20.7 14.1 10.5 14.9 11.1 15.5 10.8 11.1 14.7 9.2 0.0 0.3 0.1 0.4 0.2 0.6 0.3 0.6 0.3 0.5 0.4 0.5 0.4 0.7 0.2 0.3 0.4 0.2 0.3 9.4 8.3 6.7 13.0 9.5 8.3 6.2 10.6 7.3 5.0 15.4 8.6 8.8 12.8 9.8 4.9 6.3 11.6 4.4 7.5 13.1 111.8 10.9 9.5 12.2 2.8 9.1 3.7 150.1 7.2 7.5 15.4 1.9 6.4 214.3 15.7 7.8 9.1 6.1 12.0 11.8 6.8 11.5 11.1 11.2 12.7 9.5 8.4 7.9 10.3 5.7 294.4 11.6 7.6 10.2 6.3 4.9 821.8 6.8 5.7 7.2 11.2 4.0 124.7 5.2 9.0 11.2 10.4 9.7 6.0 8.5 6.7 8.8 3.6 10.2 96.7 0.0 10.8 7.2 15.5 14.4 12.4 11.8 5.7 6.0 4.5 10.9 6.6 STK36 "FU, KIAA1278" ENSG00000163482 "Serine/threonine kinase 36" Q9NRP7 2 218672069-218702716 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cilium biogenesis/degradation" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 37.5;Respiratory ciliated cells: 38.2;Spermatocytes: 28.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027409, HPA027453, HPA030058" Approved Supported Cytosol NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 20: HeLa - Mitochondria" "Cluster 49: Ciliated cells - Cilium organization" Cytosol "HPA027409: AB_10600223, HPA027453: AB_10601893, HPA030058: AB_10601225" "unprognostic (8.11e-2)" "unprognostic (3.77e-1)" "unprognostic (3.59e-2)" "unprognostic (1.27e-1)" "unprognostic (1.50e-1)" "unprognostic (2.52e-2)" "prognostic unfavorable (5.20e-4)" "unprognostic (1.55e-1)" "unprognostic (5.83e-3)" "unprognostic (9.04e-2)" "unprognostic (1.38e-2)" "unprognostic (1.13e-2)" "unprognostic (3.52e-3)" "unprognostic (1.46e-1)" "unprognostic (2.60e-2)" "unprognostic (1.77e-1)" "unprognostic (1.99e-3)" 5.6 9.9 1.5 5.4 1.7 2.5 6.6 1.0 3.2 14.1 15.4 9.0 4.4 11.4 13.4 5.1 14.3 10.5 3.5 2.3 1.0 7.3 4.5 7.3 4.5 1.2 2.6 13.4 10.7 9.4 14.8 4.3 0.8 9.6 6.5 11.6 7.3 8.2 3.7 5.0 6.4 8.0 0.3 5.1 8.8 32.0 1.3 3.2 11.8 2.3 4.0 8.2 7.6 1.0 3.7 8.2 17.6 15.0 18.7 14.5 10.9 9.8 7.8 12.2 11.4 10.7 6.0 4.8 13.3 10.3 8.2 7.2 12.2 10.3 10.7 2.8 10.2 4.7 27.1 15.0 9.1 6.7 7.6 15.7 7.5 12.0 8.4 32.3 9.3 6.2 11.1 6.0 10.3 8.5 4.0 8.5 10.7 4.6 5.2 7.3 7.6 5.1 14.9 18.2 14.2 12.3 7.6 12.2 5.0 18.2 12.4 5.3 8.9 16.8 6.1 6.5 6.8 7.5 6.3 2.5 10.4 3.1 7.1 0.0 0.4 0.7 0.3 0.2 0.1 0.4 0.2 0.2 0.3 0.1 0.2 0.3 0.0 0.5 0.3 0.3 0.2 0.4 1.5 1.7 1.0 3.2 2.3 1.0 1.2 2.6 0.8 0.3 1.3 1.0 2.1 9.6 6.3 18.3 1.6 1.1 0.9 3.6 2.8 7.4 7.4 5.5 4.0 5.7 3.7 3.7 37.5 1.8 2.9 2.9 0.0 3.7 16.9 17.5 9.0 3.3 2.4 0.8 22.0 2.5 1.5 4.5 10.7 6.3 1.3 12.2 3.3 5.9 2.7 1.7 18.0 4.4 6.1 2.5 1.2 6.0 5.9 2.0 0.0 2.8 2.5 4.9 1.0 8.5 6.2 2.2 5.0 4.9 0.6 1.6 2.5 4.4 38.2 9.1 6.6 3.1 4.0 28.0 8.9 3.7 1.0 0.8 1.5 11.0 4.9 0.9 STK38 "NDR, NDR1" ENSG00000112079 "Serine/threonine kinase 38" Q15208 6 36493892-36547479 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "NK-cells: 101.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004673, HPA038623, HPA051324" Uncertain Approved Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "CAB004673: AB_425892, HPA038623: AB_10967059, HPA051324: AB_2681442" "unprognostic (3.58e-3)" "unprognostic (1.80e-2)" "unprognostic (3.07e-2)" "unprognostic (6.76e-3)" "unprognostic (8.25e-2)" "unprognostic (1.47e-2)" "unprognostic (2.88e-3)" "unprognostic (2.08e-1)" "prognostic unfavorable (9.44e-5)" "unprognostic (3.78e-2)" "unprognostic (2.18e-1)" "unprognostic (3.21e-2)" "unprognostic (1.98e-2)" "unprognostic (3.80e-1)" "unprognostic (2.59e-1)" "unprognostic (1.69e-1)" "unprognostic (3.13e-3)" 27.6 11.5 13.2 28.9 13.6 30.6 23.2 15.8 18.1 23.5 15.2 40.4 24.0 21.3 12.5 39.6 21.4 20.7 24.2 14.2 13.4 23.1 24.7 24.9 34.5 14.4 13.4 16.0 12.5 8.3 14.4 21.7 13.6 23.8 36.5 11.3 33.6 16.0 16.1 30.6 41.6 27.4 13.0 34.6 23.2 13.8 14.8 28.0 14.0 16.2 33.8 30.0 28.4 14.2 43.0 31.1 32.1 34.8 63.4 47.9 27.9 46.7 37.6 47.6 47.4 24.0 28.7 57.3 35.3 70.0 39.5 44.7 26.9 19.6 55.7 23.6 23.0 41.1 40.8 21.9 31.2 15.8 21.7 31.9 50.0 36.9 23.6 54.5 30.1 28.7 34.0 32.4 68.5 25.7 25.5 40.8 13.4 50.5 27.3 97.7 38.9 15.3 45.0 52.9 37.4 17.7 57.0 25.9 34.0 35.7 27.8 40.8 29.4 38.4 33.6 30.9 30.7 27.1 51.4 39.9 8.7 60.1 37.8 91.2 45.2 34.6 57.0 49.5 44.1 22.4 46.9 50.4 29.1 16.2 41.1 45.8 59.4 59.3 73.3 14.4 48.7 58.3 13.2 13.6 15.8 18.1 14.2 13.4 14.4 13.4 13.6 13.0 14.8 14.2 29.7 19.2 16.0 27.4 25.7 13.5 9.6 21.5 21.1 3.0 16.0 14.5 15.5 18.6 47.9 7.3 0.0 13.8 59.5 47.1 1.9 18.9 9.0 15.3 16.0 18.4 14.4 16.6 46.5 12.7 17.8 22.2 34.7 20.4 13.3 13.5 12.1 15.0 13.2 5.0 34.2 25.4 22.4 38.2 20.3 5.3 27.1 40.1 17.8 57.1 48.7 7.6 101.0 38.2 36.8 27.8 30.8 30.1 39.6 12.8 32.8 16.6 40.4 7.7 13.1 8.3 14.0 26.5 10.3 31.5 21.2 15.3 45.5 10.1 28.4 27.9 STK38L "KIAA0965, NDR2" ENSG00000211455 "Serine/threonine kinase 38 like" Q9Y2H1 12 27243968-27325959 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Actin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 5 "dendritic cells: 49.9;granulocytes: 80.7;monocytes: 33.0" "Cell line enhanced" "Detected in all" "HDLM-2: 157.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038623, HPA051324" Approved Approved Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 46: Fibroblasts - ECM organization" "Cluster 44: HDLM-2 - Immune response" "Cluster 1: Pancreatic cells - Digestion" Cytosol "HPA038623: AB_10967059, HPA051324: AB_2681442" "unprognostic (2.14e-2)" "unprognostic (1.01e-1)" "unprognostic (9.94e-2)" "unprognostic (2.43e-2)" "unprognostic (2.02e-1)" "unprognostic (1.76e-1)" "unprognostic (3.33e-2)" "unprognostic (4.68e-2)" "unprognostic (5.56e-2)" "unprognostic (1.56e-1)" "prognostic unfavorable (5.82e-4)" "unprognostic (1.16e-1)" "unprognostic (3.41e-2)" "unprognostic (1.09e-1)" "unprognostic (1.95e-1)" "unprognostic (5.05e-2)" "unprognostic (1.05e-2)" 23.9 11.6 6.5 21.6 8.6 17.2 14.0 6.9 11.1 17.2 6.4 28.9 12.9 27.1 7.5 22.7 15.1 25.7 44.9 6.7 8.6 12.9 12.5 12.3 12.4 8.1 7.5 7.0 12.3 26.9 7.2 15.7 8.4 20.2 21.2 6.6 13.8 15.0 8.8 10.8 14.3 33.3 7.6 12.0 18.6 11.2 9.5 17.8 9.2 16.4 14.8 24.6 15.5 6.8 12.0 15.7 40.1 17.7 18.6 12.4 30.8 7.7 11.5 4.8 6.5 19.8 8.5 29.3 17.7 6.4 13.6 21.9 19.0 13.4 7.2 157.8 17.3 18.7 17.5 10.0 15.5 43.7 19.7 14.7 13.3 17.6 21.7 29.3 38.1 36.8 21.2 21.1 9.7 8.3 28.5 46.3 49.6 31.2 25.4 10.6 47.8 22.4 6.8 22.0 6.7 22.3 33.1 19.9 13.3 38.6 9.8 14.0 16.4 15.5 13.9 23.7 20.3 7.7 8.1 29.1 8.0 19.9 6.7 16.3 33.0 60.8 10.0 28.4 7.0 11.6 7.7 9.8 49.9 9.3 9.4 7.6 80.7 11.6 22.4 21.2 10.8 14.7 6.5 8.6 6.9 11.1 6.7 8.6 8.1 7.5 8.4 7.6 9.5 6.8 24.4 19.2 16.2 32.7 20.8 35.4 36.3 88.2 22.2 12.7 16.2 14.7 76.0 10.0 33.7 9.2 2.1 11.0 21.7 33.6 9.8 49.8 23.1 12.5 15.3 26.2 19.2 15.4 57.2 40.1 9.1 19.7 15.3 14.9 17.7 10.9 24.3 14.5 28.8 10.1 37.5 33.8 18.3 36.4 73.7 5.9 6.5 45.7 21.4 37.5 46.2 8.1 14.4 42.3 16.0 70.5 26.3 12.0 22.8 24.8 9.2 16.2 11.9 7.9 19.7 8.6 41.1 12.1 13.4 20.5 32.0 27.8 15.7 9.7 23.0 42.0 STK39 "DCHT, SPAK" ENSG00000198648 "Serine/threonine kinase 39" Q9UEW8 2 167954020-168247595 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 159.9;Inhibitory neurons: 142.9;Oligodendrocyte precursor cells: 153.3;Oligodendrocytes: 359.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB046022, HPA061803, HPA062802" Enhanced Supported Nucleoplasm,Vesicles,Cytosol NA NA 80000 "Cluster 35: T-regs - Unknown function" "Cluster 22: Non-specific - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "Vesicles, Cytosol" "CAB046022: AB_2196960, HPA061803: AB_2684616, HPA062802: AB_2684870" "prognostic favorable (3.96e-4)" "unprognostic (2.97e-2)" "unprognostic (4.40e-2)" "unprognostic (4.22e-2)" "unprognostic (4.36e-1)" "unprognostic (6.14e-2)" "prognostic unfavorable (5.67e-5)" "unprognostic (3.04e-2)" "unprognostic (8.86e-2)" "unprognostic (9.43e-2)" "unprognostic (3.20e-2)" "unprognostic (1.38e-1)" "unprognostic (2.06e-1)" "unprognostic (9.45e-2)" "unprognostic (8.61e-3)" "unprognostic (1.14e-1)" "unprognostic (6.20e-3)" 19.4 6.7 20.1 14.0 25.8 5.1 8.4 25.3 25.1 12.0 52.9 26.3 32.0 7.3 14.5 36.3 6.4 18.1 15.8 16.0 18.6 9.0 1.9 7.6 22.2 28.8 25.8 6.6 25.6 13.7 8.2 2.3 31.9 28.7 32.4 27.8 67.9 11.5 2.7 6.3 18.6 11.7 20.8 8.6 31.8 48.5 25.6 29.1 6.9 7.6 23.5 24.8 9.5 37.0 19.1 10.9 40.9 12.9 28.1 37.5 4.0 45.0 33.8 29.6 27.8 0.2 59.9 51.1 12.2 30.5 25.5 46.6 26.7 34.4 37.1 16.2 16.4 21.2 11.8 42.9 52.3 30.5 2.1 29.1 52.8 35.1 36.5 38.5 21.2 41.3 0.5 0.0 67.0 11.4 51.6 13.0 30.3 41.0 24.3 72.1 16.0 4.8 27.9 47.6 65.7 27.0 15.7 2.6 21.8 20.3 8.0 25.9 20.2 36.6 11.1 26.5 32.2 0.1 0.0 41.5 29.7 28.5 25.1 0.0 0.3 0.0 1.1 0.2 0.6 0.2 0.9 1.6 0.5 0.5 0.2 0.8 0.0 1.0 0.1 0.1 1.8 0.2 20.1 25.8 25.3 25.1 16.0 18.6 28.8 25.8 31.9 20.8 25.6 37.0 6.1 3.2 14.0 64.6 6.4 3.8 34.4 6.5 5.7 14.8 5.5 6.5 26.2 18.6 15.2 5.5 16.7 0.1 30.0 47.7 21.5 10.9 29.4 11.9 11.6 5.6 22.8 5.7 159.9 23.1 0.1 9.2 28.1 18.9 0.0 5.8 2.9 0.4 3.5 20.2 142.9 17.3 14.2 6.7 6.7 16.2 10.2 6.7 17.8 64.6 5.5 28.9 12.3 153.3 359.4 36.0 20.1 11.3 9.5 74.8 14.5 7.9 17.5 30.0 6.6 7.7 18.2 25.4 8.1 7.5 4.4 0.3 19.4 15.8 22.4 50.6 STK4 "KRS2, MST1, YSK3" ENSG00000101109 "Serine/threonine kinase 4" Q13043 20 44966479-45080021 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 57.7" "Cell type enhanced" "Detected in all" "B-cells: 372.8;dendritic cells: 341.8;Langerhans cells: 606.9;monocytes: 367.5;Plasma cells: 336.2;T-cells: 414.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004038, HPA015270" Approved Supported "Nucleoplasm,Nuclear bodies,Cytosol" NA NA 45000 "Cluster 18: Basophils - Vesicular transport" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" "Nuclear bodies" "Nucleoplasm, Cytosol" "CAB004038: AB_2144632, HPA015270: AB_1854150" "unprognostic (2.77e-1)" "unprognostic (1.10e-1)" "unprognostic (8.83e-2)" "unprognostic (8.49e-3)" "unprognostic (2.95e-2)" "unprognostic (1.24e-1)" "prognostic unfavorable (8.04e-4)" "unprognostic (1.70e-1)" "unprognostic (2.51e-1)" "unprognostic (1.05e-1)" "unprognostic (1.96e-1)" "unprognostic (2.70e-2)" "prognostic unfavorable (1.84e-5)" "unprognostic (1.28e-1)" "unprognostic (5.70e-2)" "unprognostic (3.96e-1)" "unprognostic (1.18e-2)" 10.0 8.5 6.9 33.8 8.0 57.7 9.1 6.2 10.8 7.9 9.9 11.1 10.2 8.5 7.6 9.1 6.2 11.7 4.6 7.2 8.7 6.0 9.2 15.9 43.1 8.7 7.6 7.0 6.0 5.9 4.1 10.4 9.2 6.7 13.0 7.3 7.4 8.0 3.3 11.2 13.5 9.3 8.3 30.4 12.7 9.7 7.5 33.1 7.6 4.9 41.7 15.0 6.9 10.3 27.8 18.7 23.3 16.1 13.5 16.9 16.0 23.6 35.7 39.4 35.6 52.7 14.6 66.6 20.4 16.9 33.4 28.5 24.3 31.8 49.7 30.8 13.8 48.6 27.8 36.8 23.8 63.5 66.4 13.8 25.6 36.7 39.6 19.4 14.6 44.6 23.5 37.0 19.9 21.7 47.6 42.3 13.9 17.7 12.5 30.2 25.2 31.2 14.4 18.7 10.9 13.2 35.6 20.0 27.0 17.2 18.3 39.1 18.7 29.2 28.6 34.4 27.8 48.4 41.7 73.2 28.6 29.5 22.0 80.6 19.7 54.8 34.4 19.9 34.3 26.2 32.2 32.0 18.4 26.9 33.1 28.0 101.8 28.5 38.0 10.0 34.3 22.3 6.9 8.0 6.2 10.8 7.2 8.7 8.7 7.6 9.2 8.3 7.5 10.3 26.2 16.0 24.6 18.9 372.8 55.7 49.3 33.8 28.5 27.3 22.9 17.4 7.6 14.3 25.2 42.3 52.1 24.1 341.8 23.7 9.8 16.3 5.9 19.1 25.1 32.1 25.7 46.3 76.7 17.6 30.3 29.7 34.1 25.1 133.6 114.0 26.0 22.0 61.1 43.7 38.2 20.7 28.5 109.3 606.9 5.0 22.7 154.4 133.4 85.3 367.5 20.2 278.1 34.2 48.1 21.6 27.9 17.0 336.2 32.6 23.2 13.4 26.1 69.9 13.1 25.5 29.2 44.2 42.4 20.9 53.0 19.4 414.5 48.1 19.5 45.5 STUB1 "CHIP, HSPABP2, NY-CO-7, SDCCAG7, UBOX1" ENSG00000103266 "STIP1 homology and U-box containing protein 1" Q9UNE7 16 680224-682870 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB037202, CAB037209, HPA041222, HPA043531" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Cytosol" "CAB037202: AB_1840759, CAB037209: AB_1840757, HPA041222: AB_2677368, HPA043531: AB_2678533" "unprognostic (5.70e-2)" "unprognostic (2.53e-1)" "unprognostic (1.90e-1)" "unprognostic (3.89e-1)" "unprognostic (9.00e-2)" "unprognostic (3.06e-1)" "unprognostic (4.09e-3)" "unprognostic (2.21e-1)" "unprognostic (2.23e-1)" "unprognostic (8.31e-2)" "unprognostic (5.78e-2)" "unprognostic (6.77e-2)" "prognostic favorable (6.49e-9)" "unprognostic (9.67e-2)" "unprognostic (3.57e-1)" "unprognostic (1.55e-1)" "unprognostic (1.30e-1)" 80.2 126.3 185.5 35.6 186.9 48.9 76.0 183.8 242.7 74.8 173.1 100.3 50.7 67.0 60.3 86.8 65.3 42.1 151.1 187.3 185.3 91.4 100.7 65.0 52.5 188.2 184.2 65.7 93.7 90.6 93.7 23.9 187.9 80.2 32.6 33.2 86.6 53.5 201.8 111.7 63.1 40.1 180.6 70.0 86.2 45.1 193.5 42.3 72.9 125.2 38.2 80.7 69.1 188.0 81.6 107.6 59.4 108.0 123.4 102.5 43.8 112.8 95.1 100.9 90.5 131.0 97.1 83.0 78.2 147.5 69.1 69.7 73.0 137.3 42.9 93.6 318.8 53.4 154.1 104.7 183.7 85.9 96.4 141.1 134.3 118.2 71.4 76.3 106.2 72.3 87.1 119.2 149.3 318.4 90.1 85.4 76.4 107.1 127.5 143.5 46.8 200.6 132.5 72.6 121.1 103.4 89.4 165.8 137.1 35.9 114.1 147.8 108.7 104.3 99.8 94.3 125.9 137.6 150.2 132.3 83.8 73.9 122.0 17.7 13.6 21.7 15.7 12.9 14.5 19.6 13.5 13.8 12.1 21.0 12.8 11.6 13.4 11.2 13.9 20.7 13.2 7.2 185.5 186.9 183.8 242.7 187.3 185.3 188.2 184.2 187.9 180.6 193.5 188.0 96.2 38.5 27.9 24.5 88.9 114.7 107.2 63.9 83.1 93.3 137.1 158.7 1.0 104.4 52.4 130.6 52.1 80.1 101.4 142.7 285.7 139.6 8.6 82.8 69.6 71.6 76.0 68.5 23.2 169.7 93.8 85.7 68.3 65.0 21.0 97.9 80.3 122.1 113.1 84.1 21.1 101.4 85.5 69.4 94.9 16.7 109.0 79.0 117.4 15.0 154.4 184.3 110.2 14.1 24.8 190.2 110.8 112.1 108.6 160.8 165.5 324.1 61.2 83.9 72.3 82.3 129.7 50.4 62.4 107.0 120.5 100.7 96.2 132.5 109.3 118.8 STYXL1 "DUSP24, MK-STYX" ENSG00000127952 "Serine/threonine/tyrosine interacting like 1" Q9Y6J8 7 75996338-76048004 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 91.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA050261 Uncertain NA No "Cluster 31: Non-specific - Inflammatory response" "Cluster 27: Brain & Skin - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 49: Ciliated cells - Cilium organization" "HPA050261: AB_2681066" "unprognostic (6.24e-2)" "unprognostic (1.12e-1)" "unprognostic (7.21e-2)" "unprognostic (1.81e-2)" "unprognostic (2.88e-3)" "unprognostic (9.33e-2)" "unprognostic (1.50e-3)" "unprognostic (4.77e-2)" "unprognostic (8.01e-2)" "unprognostic (4.02e-2)" "unprognostic (4.47e-3)" "unprognostic (1.47e-1)" "unprognostic (1.87e-1)" "unprognostic (5.45e-2)" "unprognostic (3.17e-2)" "unprognostic (2.28e-1)" "prognostic favorable (8.22e-4)" 8.7 15.4 21.9 11.5 22.5 15.1 17.4 21.3 26.5 15.3 24.6 15.9 11.2 10.5 20.7 18.9 28.7 9.8 11.5 21.7 19.7 16.8 19.4 11.9 16.1 21.0 20.8 15.2 22.5 16.3 11.9 17.3 22.0 16.5 20.4 13.1 16.2 10.1 10.5 20.4 9.1 14.4 20.2 14.4 14.8 21.9 21.3 13.2 14.8 9.6 21.6 14.2 13.4 23.8 50.3 26.2 20.3 27.2 31.4 33.6 21.1 22.1 31.3 35.1 34.7 30.6 44.2 11.7 10.9 29.4 55.6 21.6 33.3 44.3 50.5 37.4 14.5 14.2 12.2 27.5 44.3 19.9 24.7 33.2 51.0 42.1 104.8 45.0 34.5 17.4 46.4 34.1 31.8 40.8 7.9 84.6 17.1 48.2 62.5 30.1 16.9 31.1 45.2 32.2 26.5 27.6 20.7 46.7 57.6 50.4 51.5 38.0 17.3 29.9 12.6 33.3 31.8 36.6 24.9 39.5 26.7 37.5 47.8 70.8 52.9 50.0 23.8 48.2 26.3 36.3 22.5 26.6 42.1 29.7 19.8 22.2 44.9 49.7 47.0 28.1 41.4 34.1 21.9 22.5 21.3 26.5 21.7 19.7 21.0 20.8 22.0 20.2 21.3 23.8 7.7 22.4 13.2 16.6 10.7 7.4 14.8 24.2 13.1 6.7 17.9 18.5 18.1 10.0 31.4 11.0 0.0 34.8 7.3 24.6 39.2 15.6 91.4 42.7 10.2 11.1 20.3 9.0 18.8 25.6 24.5 9.4 18.3 19.7 10.8 13.9 11.7 18.2 30.9 3.3 11.6 29.1 24.4 21.0 9.6 62.1 11.5 19.7 3.6 11.2 31.1 20.2 9.2 8.0 15.8 23.9 40.3 10.1 23.0 17.0 14.6 25.2 60.7 10.4 6.6 7.6 9.0 39.3 12.6 13.0 9.9 45.0 10.8 9.5 18.8 17.9 STYXL2 DUSP27 ENSG00000198842 "Serine/threonine/tyrosine interacting like 2" Q5VZP5 1 167094075-167129165 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 42 "heart muscle: 63.6;skeletal muscle: 114.6;tongue: 54.1" "Cell type enriched" "Detected in some" 7 "Cardiomyocytes: 143.6" "Group enriched" "Detected in many" 6 "colorectal cancer: 12.8;stomach cancer: 3.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 6 "RH-30: 14.2" "Low region specificity" "Detected in single" "Not detected" "Not detected" HPA012912 Approved Nucleoplasm NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm "HPA012912: AB_2668767" "unprognostic (1.26e-2)" "unprognostic (1.74e-1)" "unprognostic (1.44e-3)" "unprognostic (1.22e-1)" "unprognostic (2.10e-3)" "unprognostic (4.65e-2)" "unprognostic (1.53e-1)" "unprognostic (8.19e-2)" "unprognostic (1.07e-2)" "unprognostic (1.48e-1)" "unprognostic (2.44e-2)" "unprognostic (1.15e-1)" "unprognostic (2.72e-1)" "unprognostic (7.65e-2)" "unprognostic (8.23e-2)" "unprognostic (3.39e-1)" 0.1 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.9 0.1 0.1 63.6 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 1.7 0.0 0.9 1.6 0.0 114.6 0.1 0.0 0.2 0.0 0.0 0.0 0.1 0.2 0.0 0.0 54.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 14.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 143.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.5 3.6 0.0 0.0 0.0 0.0 0.0 0.0 18.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 SYVN1 "DER3, HRD1" ENSG00000162298 "Synoviolin 1" Q86TM6 11 65121780-65134532 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Stress response, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hepatocytes: 72.9;Plasma cells: 90.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 205.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005480, HPA024300, CAB037030" Enhanced Supported "Nucleoplasm,Endoplasmic reticulum,Plasma membrane" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 29: Non-specific - Vesicular transport" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 57: B-cells - Immune response" Nucleoplasm "Endoplasmic reticulum, Plasma membrane" "CAB037030: AB_1840939, HPA005480: AB_1079084, HPA024300: AB_1851073" "unprognostic (1.12e-1)" "unprognostic (3.10e-1)" "unprognostic (1.22e-1)" "unprognostic (2.17e-2)" "unprognostic (2.85e-2)" "prognostic favorable (6.88e-4)" "unprognostic (7.67e-2)" "unprognostic (2.50e-2)" "unprognostic (2.64e-2)" "unprognostic (1.30e-1)" "unprognostic (1.59e-1)" "unprognostic (1.12e-1)" "unprognostic (1.77e-2)" "unprognostic (1.56e-2)" "unprognostic (4.89e-1)" "unprognostic (3.85e-2)" "unprognostic (1.16e-1)" 29.2 40.3 19.3 37.1 25.6 31.0 27.6 23.2 21.4 30.7 26.7 29.2 26.1 29.1 38.8 28.4 30.6 19.7 25.3 18.6 21.2 24.5 117.5 27.0 60.9 27.9 25.6 30.9 90.9 35.0 38.2 26.2 24.6 28.5 29.0 18.7 55.9 30.3 34.2 29.3 39.4 25.9 22.8 51.2 39.4 24.3 23.4 18.3 43.4 19.0 81.1 25.8 24.8 25.9 32.4 40.6 24.0 32.5 59.8 33.8 23.8 32.8 33.5 40.9 28.8 22.2 55.0 181.0 43.8 42.4 53.8 48.8 26.4 33.3 33.6 28.4 20.0 28.6 46.8 50.2 72.3 43.3 49.6 43.3 59.0 36.1 81.0 36.4 27.0 19.0 36.4 90.1 24.3 47.9 19.1 31.2 26.1 33.6 28.0 31.9 20.3 74.0 25.7 31.5 15.6 32.0 30.4 74.1 53.3 21.0 55.4 28.2 25.9 28.3 18.6 51.2 22.4 178.1 134.2 205.9 38.1 21.8 32.3 16.8 7.4 14.0 7.4 4.7 6.5 21.9 5.2 6.9 4.4 22.6 3.7 3.9 7.0 3.5 4.7 18.4 5.3 6.6 19.3 25.6 23.2 21.4 18.6 21.2 27.9 25.6 24.6 22.8 23.4 25.9 11.5 16.0 21.4 11.1 43.5 17.6 6.9 13.8 12.0 10.7 21.0 15.5 4.0 22.8 20.8 11.0 33.3 14.5 16.4 23.1 1.9 13.6 6.6 14.2 16.2 11.3 8.4 13.2 9.6 18.9 16.5 14.2 17.9 22.1 1.3 10.1 15.0 72.9 15.1 13.5 9.5 33.6 16.2 15.3 13.2 4.1 20.5 10.8 12.4 9.4 10.5 11.0 13.4 13.0 15.8 18.2 11.7 13.2 90.5 14.9 14.0 7.7 15.1 18.7 13.1 11.9 10.7 19.3 13.2 9.7 16.1 42.8 11.7 13.6 18.6 13.8 TAF1 "BA2R, CCG1, CCGS, DYT3, DYT3/TAF1, KAT4, NSCL2, TAF2A, TAFII250" ENSG00000147133 "TATA-box binding protein associated factor 1" P21675 X 71366264-71532374 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Cell cycle, Host-virus interaction, Transcription, Transcription regulation" "Acyltransferase, DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Dystonia, Mental retardation, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 81.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "HPA001075, CAB016283" Supported Supported Nucleoplasm NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 32: U-937 - Innate immune response" "Cluster 9: Photoreceptor cells - Phototransduction" Nucleoplasm "CAB016283: AB_671202, HPA001075: AB_1080179" "unprognostic (2.95e-2)" "unprognostic (1.77e-1)" "unprognostic (6.45e-3)" "unprognostic (1.91e-2)" "unprognostic (1.88e-2)" "unprognostic (1.23e-1)" "unprognostic (1.44e-1)" "prognostic favorable (6.54e-4)" "unprognostic (2.68e-2)" "unprognostic (3.43e-2)" "unprognostic (2.03e-1)" "unprognostic (5.59e-2)" "prognostic unfavorable (6.03e-4)" "unprognostic (1.14e-2)" "unprognostic (1.41e-1)" "unprognostic (1.82e-2)" "unprognostic (2.56e-2)" 10.9 8.6 10.3 11.4 12.7 12.8 12.3 13.7 11.1 11.1 10.2 10.0 6.6 13.8 12.9 7.5 11.1 7.8 7.0 9.3 14.1 7.5 7.8 9.1 14.1 11.5 11.3 14.4 9.8 12.2 8.4 10.0 10.9 10.0 10.0 27.3 7.7 10.1 10.5 13.3 9.3 10.9 8.2 15.4 10.6 7.2 12.5 14.8 12.7 10.3 12.4 9.2 8.6 16.8 18.6 15.9 18.2 12.4 14.6 23.2 11.0 13.3 12.1 13.7 11.1 12.3 11.3 17.6 11.5 14.9 12.3 17.5 24.1 11.0 17.0 11.2 21.9 20.1 22.1 13.1 11.1 39.7 19.4 14.1 11.3 14.2 27.2 12.8 14.7 13.2 28.2 41.1 14.4 14.5 22.4 25.4 20.9 23.5 20.8 19.8 35.8 21.6 11.1 25.0 9.0 14.5 37.7 13.6 18.7 14.3 9.6 22.9 18.6 16.5 14.2 13.4 9.7 17.5 17.4 21.4 9.0 33.2 12.5 1.6 1.4 0.7 1.4 0.9 1.3 1.0 1.4 1.4 1.5 1.5 1.6 1.8 1.8 1.5 1.6 1.4 1.0 0.7 10.3 12.7 13.7 11.1 9.3 14.1 11.5 11.3 10.9 8.2 12.5 16.8 26.7 32.1 26.7 44.7 21.2 11.9 8.9 10.4 18.2 37.5 12.5 13.3 17.2 10.0 23.9 3.7 81.3 8.6 21.5 7.8 1.9 6.3 2.5 17.0 23.4 24.6 11.4 28.6 54.3 7.0 5.9 17.6 12.2 18.9 23.4 23.9 18.9 12.6 8.8 16.8 52.2 14.6 6.1 16.2 20.0 2.6 22.1 20.4 5.4 47.8 23.9 17.0 29.9 49.3 79.1 7.6 13.3 22.2 18.7 11.2 13.4 5.2 14.8 67.9 0.0 27.4 18.0 9.3 10.7 17.8 17.3 5.7 23.8 25.9 13.6 9.6 TAOK1 "FLJ14314, KIAA1361, MAP3K16, MARKK, PSK2, TAO1" ENSG00000160551 "TAO kinase 1" Q7L7X3 17 29390363-29551903 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, DNA damage, DNA repair" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 220.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007669 Approved Uncertain Vesicles NA NA 1600000 "Cluster 1: Neutrophils - Mixed function" "Cluster 21: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Vesicles "HPA007669: AB_1080201" "unprognostic (1.46e-1)" "unprognostic (7.15e-3)" "unprognostic (2.70e-2)" "unprognostic (1.52e-1)" "unprognostic (1.81e-2)" "unprognostic (4.85e-2)" "unprognostic (1.28e-2)" "unprognostic (4.31e-2)" "unprognostic (1.15e-1)" "unprognostic (6.91e-2)" "unprognostic (1.61e-1)" "unprognostic (1.36e-1)" "unprognostic (2.85e-2)" "unprognostic (5.53e-3)" "unprognostic (3.57e-1)" "unprognostic (1.66e-1)" "unprognostic (2.62e-1)" 13.7 9.1 12.0 9.8 16.0 10.5 10.3 13.8 13.1 11.8 1.2 9.5 5.2 10.8 8.5 10.3 7.9 9.6 13.2 13.3 12.8 10.2 8.6 9.8 9.9 16.4 14.5 10.3 7.8 19.4 8.0 11.7 14.9 9.0 8.5 20.9 7.8 10.0 11.4 10.4 7.3 11.7 13.2 10.4 8.1 11.7 13.9 13.2 14.5 15.2 9.5 12.1 8.7 20.4 19.3 35.0 32.1 13.4 24.1 29.8 11.3 20.0 23.9 20.3 21.1 20.7 7.9 13.8 15.8 35.9 20.7 16.3 30.4 15.7 36.4 20.7 18.2 21.0 21.3 12.2 16.6 26.5 16.7 19.4 19.6 29.0 30.6 21.3 27.3 14.0 20.7 12.0 26.7 14.2 18.5 9.5 12.0 12.9 8.6 15.1 41.2 8.8 19.1 31.5 16.1 18.7 34.6 34.4 21.1 32.6 23.6 21.6 33.6 28.0 19.7 23.7 27.5 9.3 18.6 14.0 20.3 14.8 24.3 0.6 0.5 0.5 0.6 0.6 0.5 0.5 0.6 0.7 0.5 0.6 0.7 0.7 1.7 0.5 0.6 1.4 0.4 0.3 12.0 16.0 13.8 13.1 13.3 12.8 16.4 14.5 14.9 13.2 13.9 20.4 96.9 48.1 45.8 105.8 35.9 44.5 27.4 27.0 52.9 56.6 35.5 23.2 90.2 30.0 37.7 46.0 98.0 18.7 40.5 29.3 15.6 27.3 11.8 45.0 72.0 55.4 37.7 18.7 162.3 24.3 16.0 58.0 31.6 80.1 28.5 44.3 52.1 29.5 30.1 52.2 160.5 23.7 24.4 65.6 60.4 19.8 39.7 67.3 40.9 92.8 55.8 37.1 29.9 142.2 220.8 38.9 24.0 54.2 34.2 40.4 17.6 22.1 31.0 54.7 26.3 66.1 52.1 59.1 33.2 49.5 45.9 37.6 43.1 43.0 21.1 41.6 TAOK2 "KIAA0881, MAP3K17, PSK, PSK1, TAO1, TAO2" ENSG00000149930 "TAO kinase 2" Q9UL54 16 29973868-29992261 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Adipocytes: 52.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA010650 Approved Approved Nucleoplasm,Nucleoli,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 72: Non-specific - Transcription" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Nucleoplasm, Cytosol" Nucleoli "HPA010650: AB_1080204" "unprognostic (7.30e-2)" "unprognostic (1.78e-1)" "prognostic unfavorable (2.51e-4)" "prognostic favorable (3.87e-5)" "unprognostic (8.46e-2)" "unprognostic (2.14e-3)" "unprognostic (6.08e-2)" "unprognostic (1.12e-3)" "unprognostic (1.01e-2)" "unprognostic (1.60e-1)" "prognostic favorable (4.78e-4)" "unprognostic (3.85e-3)" "prognostic favorable (3.66e-4)" "unprognostic (7.42e-3)" "unprognostic (3.17e-1)" "unprognostic (7.47e-2)" "unprognostic (1.37e-1)" 31.4 36.0 23.4 14.7 21.2 12.7 30.8 18.0 26.1 24.8 11.9 21.8 17.3 25.9 11.1 20.8 22.6 12.0 32.6 23.0 18.9 22.7 17.6 34.0 14.4 21.0 20.0 24.1 19.5 17.4 29.4 19.4 18.9 22.5 8.5 14.3 20.5 13.3 23.4 22.4 24.4 13.3 15.3 33.8 21.8 34.8 20.8 13.2 25.4 12.7 10.5 22.4 21.6 19.0 22.2 41.8 22.4 35.1 25.8 17.1 34.2 40.0 21.1 26.4 24.4 33.6 28.7 23.8 32.8 28.8 18.0 33.9 20.4 20.0 14.1 37.5 43.3 25.8 46.2 34.8 18.7 25.5 47.5 20.0 17.1 28.1 11.2 18.5 44.7 22.4 23.5 23.6 25.8 41.0 29.8 36.0 21.5 16.4 27.6 54.2 32.5 22.2 16.6 20.5 26.1 20.8 22.8 30.2 12.1 14.4 37.5 28.5 62.9 45.0 20.7 32.4 23.6 34.2 23.7 22.1 27.6 28.8 33.7 0.3 0.7 0.4 0.7 0.7 0.8 0.5 0.7 0.6 0.4 0.6 0.4 0.3 1.2 0.5 0.4 0.8 0.9 0.6 23.4 21.2 18.0 26.1 23.0 18.9 21.0 20.0 18.9 15.3 20.8 19.0 52.0 9.6 11.5 21.9 6.3 10.7 4.6 7.5 7.4 14.6 10.5 5.7 9.8 7.2 9.1 9.2 39.6 7.8 7.6 27.0 1.9 8.5 3.9 8.7 9.5 35.3 13.1 3.4 7.9 12.0 6.2 9.7 14.3 8.9 3.8 16.0 47.2 11.8 9.8 10.1 10.7 16.8 12.2 11.2 11.1 4.4 12.5 8.2 7.2 7.5 9.0 8.4 11.3 9.0 12.7 16.1 14.8 12.8 5.9 7.4 27.2 8.0 10.0 21.4 6.6 8.7 8.7 19.7 21.6 9.1 9.7 12.0 9.2 16.0 14.7 7.4 TAOK3 "DPK, JIK, MAP3K18" ENSG00000135090 "TAO kinase 3" Q9H2K8 12 118149801-118372907 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocyte precursor cells: 400.6;Rod photoreceptor cells: 323.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HMC-1: 123.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017160 Approved Uncertain Mitochondria NA NA 520000 "Cluster 18: Basophils - Vesicular transport" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 46: Photoreceptor cells - Phototransduction" Mitochondria "HPA017160: AB_1851994" "unprognostic (3.21e-1)" "unprognostic (1.31e-1)" "unprognostic (1.65e-1)" "unprognostic (3.74e-2)" "unprognostic (5.18e-2)" "unprognostic (2.09e-1)" "unprognostic (4.80e-1)" "unprognostic (5.86e-2)" "unprognostic (1.00e-1)" "unprognostic (7.38e-2)" "unprognostic (2.76e-2)" "unprognostic (8.23e-2)" "unprognostic (1.08e-2)" "unprognostic (2.08e-2)" "unprognostic (4.14e-3)" "unprognostic (2.56e-1)" "unprognostic (1.44e-1)" 15.4 18.2 33.9 24.9 35.7 41.9 17.1 36.8 38.5 12.7 27.9 23.8 27.1 16.8 12.7 18.2 10.5 19.5 18.5 33.0 38.1 16.2 18.4 23.2 33.8 34.2 35.3 19.3 11.7 15.5 18.7 14.3 33.5 29.0 24.6 48.3 15.2 16.0 21.8 20.3 28.8 17.7 33.6 26.0 25.2 10.7 41.2 31.6 21.1 13.0 33.0 20.6 13.3 42.6 25.7 17.2 12.7 11.1 30.6 37.0 14.5 26.2 29.8 14.9 19.3 8.9 38.5 77.4 8.4 34.9 21.5 22.5 11.2 23.5 23.3 28.3 9.2 91.7 9.0 11.7 35.6 95.2 123.5 25.3 27.7 46.9 68.4 31.3 48.3 45.5 54.3 9.0 27.8 18.2 50.0 62.0 4.7 11.7 9.2 29.1 17.2 8.3 14.1 43.8 2.3 12.5 24.1 10.9 33.6 5.5 22.0 70.0 75.9 25.5 4.5 24.2 22.6 8.7 8.9 60.6 35.8 64.1 35.2 122.3 39.4 91.5 60.9 53.8 58.1 47.9 46.0 53.4 52.4 44.9 40.3 52.9 86.2 86.9 95.4 48.8 46.6 46.0 33.9 35.7 36.8 38.5 33.0 38.1 34.2 35.3 33.5 33.6 41.2 42.6 43.2 35.3 98.9 203.4 110.7 35.2 46.7 30.4 38.1 69.9 52.3 39.6 57.6 52.9 36.7 46.0 212.7 36.1 138.5 116.3 70.5 40.3 18.6 17.5 30.6 36.2 25.1 65.2 117.0 59.1 93.5 37.8 75.4 39.2 167.6 31.6 29.6 57.7 78.5 40.4 156.2 80.7 22.4 104.3 103.0 10.3 38.8 160.5 35.6 133.0 156.9 48.4 217.3 400.6 202.2 91.0 111.7 47.8 84.9 44.4 105.2 37.4 20.7 323.8 46.0 29.9 55.2 101.4 53.3 48.3 31.4 43.8 103.5 66.4 69.3 53.7 TBK1 NAK ENSG00000183735 "TANK binding kinase 1" Q9UHD2 12 64452090-64502114 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Antiviral defense, Host-virus interaction, Immunity, Innate immunity" "Kinase, Serine/threonine-protein kinase, Transferase" "Amyotrophic lateral sclerosis, Disease variant, Glaucoma, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045797, HPA060211" Uncertain Enhanced Nucleoplasm,Vesicles NA NA "Cluster 34: Basophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm Vesicles "HPA045797: AB_2679457, HPA060211: AB_2684222" "unprognostic (4.73e-2)" "unprognostic (8.46e-2)" "unprognostic (6.07e-3)" "unprognostic (1.90e-1)" "unprognostic (1.94e-1)" "unprognostic (1.28e-1)" "prognostic unfavorable (3.30e-4)" "unprognostic (1.26e-1)" "prognostic unfavorable (3.48e-4)" "unprognostic (1.69e-1)" "unprognostic (2.54e-2)" "unprognostic (1.24e-2)" "prognostic unfavorable (4.20e-6)" "unprognostic (4.35e-2)" "unprognostic (1.30e-1)" "unprognostic (1.26e-2)" "unprognostic (9.56e-3)" 11.6 15.3 6.0 10.1 6.1 16.9 11.4 5.6 6.9 10.6 5.3 10.5 15.1 11.0 6.7 11.3 9.5 10.1 9.4 5.8 5.6 11.8 17.4 12.9 14.6 6.5 6.9 9.6 7.5 11.6 9.8 13.7 6.1 10.6 8.5 6.3 10.2 9.0 18.4 8.6 11.4 10.8 5.3 13.4 10.2 23.5 6.7 6.8 8.5 14.9 12.9 16.0 10.2 7.1 23.3 24.2 11.1 10.6 24.7 26.1 29.0 22.9 37.6 22.5 21.1 14.9 12.4 31.5 21.4 26.8 34.4 19.0 19.4 20.0 26.4 29.5 17.1 33.0 15.3 19.1 30.2 35.2 36.4 18.5 19.1 23.1 23.6 42.3 32.4 11.0 27.9 38.7 31.6 27.0 0.9 17.0 29.9 22.9 13.8 14.9 15.3 31.8 25.1 36.9 9.8 14.7 33.3 36.0 23.5 23.5 33.1 24.9 25.9 20.2 18.1 14.9 24.0 25.4 54.3 30.3 28.1 18.6 26.1 41.8 10.1 24.3 13.9 17.7 16.3 12.8 10.1 15.2 12.2 10.1 2.8 8.7 17.8 26.6 15.5 2.1 13.6 10.0 6.0 6.1 5.6 6.9 5.8 5.6 6.5 6.9 6.1 5.3 6.7 7.1 23.7 19.2 20.5 28.4 21.6 11.0 25.7 20.1 15.4 17.0 14.9 9.1 10.9 8.6 23.4 22.0 10.4 28.8 30.0 14.1 11.7 19.3 34.5 19.2 17.9 28.6 17.3 18.3 50.5 23.6 32.6 21.3 15.3 30.2 43.1 17.5 16.8 17.1 20.2 18.5 42.2 10.5 12.2 23.0 30.2 29.2 19.3 31.1 14.2 46.9 31.4 12.7 33.0 39.2 52.3 16.9 10.9 20.7 25.6 43.7 13.6 12.3 20.8 16.3 26.3 22.4 18.7 68.9 12.7 14.0 14.9 92.6 27.1 11.5 10.1 41.6 TBL1X "EBI, TBL1" ENSG00000101849 "Transducin beta like 1 X-linked" O60907 X 9463295-9741037 "Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" Activator "Congenital hypothyroidism, Deafness, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 103.8;Oligodendrocytes: 109.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 18.7" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "CAB005363, HPA067703" Approved Approved Nucleoplasm,Nucleoli NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 68: Epididymis - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 36: Stromal cells - Cell proliferation" Nucleoplasm Nucleoli "CAB005363: AB_2240272, HPA067703: AB_2685892" "prognostic unfavorable (8.50e-4)" "unprognostic (2.03e-1)" "unprognostic (2.12e-1)" "unprognostic (2.89e-2)" "unprognostic (2.44e-1)" "unprognostic (1.40e-2)" "unprognostic (2.21e-3)" "unprognostic (3.09e-1)" "unprognostic (2.70e-1)" "unprognostic (3.27e-1)" "prognostic favorable (1.32e-4)" "unprognostic (2.66e-1)" "prognostic favorable (4.58e-4)" "unprognostic (6.71e-2)" "unprognostic (6.38e-2)" "unprognostic (3.40e-3)" "unprognostic (1.53e-1)" 9.3 9.1 20.0 8.7 21.3 7.2 9.7 17.4 16.7 18.1 14.2 9.4 2.8 38.4 35.3 10.2 16.6 7.1 7.3 16.7 21.1 16.6 13.6 5.8 9.0 23.8 20.2 18.0 9.2 23.9 18.7 20.7 19.7 25.4 5.3 16.5 7.3 43.2 4.6 7.5 5.0 26.6 18.6 8.4 8.1 9.7 26.7 18.4 12.0 5.2 10.2 13.5 12.7 20.0 0.1 29.6 18.5 49.2 16.8 17.4 18.4 11.3 25.0 21.3 22.2 22.4 20.2 31.6 0.8 22.7 9.1 6.7 40.7 8.9 30.9 13.0 19.6 20.0 35.6 26.5 23.7 7.2 68.6 15.6 10.1 22.3 11.8 11.7 19.9 17.2 35.8 53.5 12.5 25.6 17.8 27.2 36.7 14.2 31.5 39.3 14.5 39.3 28.9 16.9 23.4 10.6 27.2 6.8 16.9 48.2 13.3 15.6 29.1 7.5 18.3 0.8 4.6 32.6 27.8 25.1 27.2 17.4 7.1 6.3 4.7 5.7 2.2 2.9 1.8 2.2 1.7 2.0 3.5 3.6 3.1 2.9 18.7 0.3 2.0 0.3 2.9 2.1 20.0 21.3 17.4 16.7 16.7 21.1 23.8 20.2 19.7 18.6 26.7 20.0 12.6 0.0 4.5 103.8 17.3 6.5 13.2 3.8 9.1 11.8 19.1 18.0 10.1 20.0 6.8 31.3 22.9 78.1 20.4 7.9 13.7 10.7 1.0 34.4 80.7 10.3 22.8 3.8 12.5 7.8 6.0 13.1 9.7 51.1 11.4 32.5 11.4 64.3 11.3 6.7 17.1 5.4 2.0 33.0 22.8 3.2 14.3 19.7 5.4 61.8 37.5 46.6 19.6 46.3 109.7 7.5 7.9 28.6 9.5 24.1 0.2 21.8 10.0 24.5 0.0 9.4 27.9 1.4 18.0 16.5 12.4 45.0 18.8 22.3 4.9 23.7 TBL1XR1 "C21, DC42, FLJ12894, IRA1, TBLR1" ENSG00000177565 "TBL1X receptor 1" Q9BZK7 3 177019340-177228000 "Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Chromatin regulator, Repressor" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 280.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019182 Supported Approved Nucleoplasm NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 34: Non-specific - Transcription" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 44: Endometrium - Transcription" Nucleoplasm "HPA019182: AB_1857800" "unprognostic (4.11e-2)" "unprognostic (3.00e-1)" "unprognostic (1.33e-2)" "unprognostic (1.27e-3)" "prognostic favorable (5.16e-5)" "unprognostic (4.44e-2)" "prognostic unfavorable (1.08e-7)" "unprognostic (3.75e-1)" "unprognostic (4.84e-2)" "unprognostic (3.04e-1)" "unprognostic (3.13e-3)" "unprognostic (2.50e-1)" "prognostic unfavorable (4.25e-5)" "unprognostic (5.83e-2)" "unprognostic (1.69e-1)" "unprognostic (1.50e-1)" "unprognostic (1.17e-1)" 18.8 20.3 7.2 24.4 12.7 30.2 21.7 13.9 11.8 24.9 8.5 31.0 24.6 16.9 9.2 21.2 22.4 23.2 32.6 16.0 3.3 22.3 24.5 19.6 31.3 8.1 8.5 20.9 12.1 27.3 2.9 21.0 4.9 25.6 24.4 42.7 16.1 14.8 12.9 17.1 18.7 19.4 8.6 22.9 22.3 19.1 8.4 45.5 47.1 25.3 36.3 25.3 10.3 15.0 96.8 41.2 61.1 39.7 56.2 65.8 44.2 26.1 52.3 30.3 36.3 48.9 76.2 98.9 132.9 43.6 58.4 61.2 42.9 63.2 58.7 97.5 14.5 56.2 66.8 30.3 49.7 91.0 29.6 95.3 35.9 37.3 90.6 53.8 48.5 68.5 44.8 189.9 42.8 31.0 81.7 14.0 38.1 59.8 32.2 53.9 72.6 124.6 33.1 119.5 24.8 38.7 43.3 35.9 49.8 37.3 113.0 74.3 60.5 48.9 35.3 28.8 65.6 89.8 117.6 280.7 32.9 66.2 56.1 14.3 3.7 3.8 5.6 6.2 5.9 7.5 6.9 7.3 4.6 7.3 5.9 7.4 12.9 7.4 5.5 12.4 8.3 5.3 7.2 12.7 13.9 11.8 16.0 3.3 8.1 8.5 4.9 8.6 8.4 15.0 55.1 73.7 60.7 128.0 56.5 91.5 55.1 90.6 62.0 113.6 69.2 42.2 101.9 47.1 80.3 104.8 125.1 28.9 70.0 84.7 29.4 52.2 7.4 90.9 59.0 65.5 85.3 60.4 228.9 43.8 35.1 81.8 44.4 134.5 25.3 65.9 48.5 66.6 37.8 116.1 167.6 72.6 59.0 91.1 75.0 9.0 64.0 69.4 65.8 184.6 55.8 47.6 41.2 241.8 269.4 66.7 43.7 73.0 75.1 144.9 41.5 67.3 83.9 81.6 46.0 76.3 54.4 12.9 61.4 88.1 111.8 27.5 66.0 41.6 84.6 83.6 TESK1 ENSG00000107140 "Testis associated actin remodelling kinase 1" Q15569 9 35605262-35610041 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 41: Macrophages - Immune response" "unprognostic (5.17e-2)" "unprognostic (2.82e-1)" "unprognostic (4.96e-3)" "unprognostic (5.18e-2)" "unprognostic (2.04e-2)" "unprognostic (8.76e-2)" "prognostic unfavorable (9.68e-4)" "unprognostic (1.82e-2)" "unprognostic (1.24e-1)" "unprognostic (2.66e-3)" "unprognostic (1.22e-2)" "unprognostic (2.56e-1)" "unprognostic (5.57e-2)" "unprognostic (1.74e-2)" "unprognostic (2.34e-1)" "unprognostic (1.43e-2)" "unprognostic (1.25e-3)" 40.2 44.7 24.4 11.2 22.0 6.1 33.5 17.9 25.9 22.6 14.8 29.9 13.3 25.7 11.1 12.8 18.7 13.0 19.2 22.0 21.3 18.0 13.8 19.9 11.9 20.6 24.2 15.9 16.0 16.8 26.6 9.1 21.8 22.4 8.5 6.7 17.4 19.8 69.2 19.1 18.9 17.1 18.2 16.2 22.2 57.0 28.1 10.4 19.0 27.6 8.5 27.9 16.0 20.4 17.0 16.0 10.7 16.9 42.5 17.5 12.1 19.7 17.3 17.8 11.3 9.3 4.8 30.9 10.3 19.7 47.1 5.8 6.8 14.1 3.4 20.0 9.2 4.6 14.1 8.4 24.4 4.0 14.6 17.2 21.8 13.9 19.0 18.9 12.6 15.3 5.3 11.3 18.0 19.1 7.9 18.4 6.2 16.1 18.6 12.9 6.6 7.3 13.1 8.0 8.8 10.3 11.2 13.0 8.1 7.3 15.9 5.7 11.1 39.2 16.2 27.9 12.0 6.0 10.2 11.2 28.2 4.6 9.1 0.0 0.6 0.1 1.1 0.1 1.0 0.3 0.4 1.8 0.8 0.2 0.5 0.5 0.0 0.9 0.3 0.8 0.1 0.7 24.4 22.0 17.9 25.9 22.0 21.3 20.6 24.2 21.8 18.2 28.1 20.4 13.4 6.4 7.7 9.1 8.9 14.4 6.3 5.9 4.6 10.9 13.9 11.0 1.9 7.2 4.2 7.3 8.4 3.8 20.0 19.9 1.9 6.6 35.1 5.6 9.2 9.7 9.5 1.7 6.5 10.4 8.6 9.0 18.8 11.2 1.3 10.1 10.8 8.4 13.9 13.5 8.5 14.8 0.0 7.8 22.4 34.9 12.2 19.3 14.2 2.8 6.3 12.6 20.6 4.5 6.8 10.2 11.0 14.3 10.7 19.2 13.4 7.8 4.2 15.3 6.6 10.1 10.9 14.8 10.0 4.7 13.9 3.3 11.8 5.4 7.3 9.7 TESK2 ENSG00000070759 "Testis associated actin remodelling kinase 2" Q96S53 1 45343883-45491163 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in many" 4 "Oligodendrocytes: 222.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BEWO: 14.6;RT4: 14.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027257, HPA063869" Uncertain Enhanced Nucleoplasm NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 2: Karpas-707 - Immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA027257: AB_10602477, HPA063869: AB_2685137" "unprognostic (2.95e-1)" "prognostic favorable (2.22e-4)" "unprognostic (3.90e-2)" "unprognostic (5.04e-3)" "unprognostic (6.03e-2)" "unprognostic (1.87e-3)" "unprognostic (3.22e-2)" "unprognostic (1.43e-2)" "unprognostic (5.15e-2)" "unprognostic (2.96e-1)" "unprognostic (2.28e-1)" "unprognostic (2.86e-1)" "unprognostic (4.36e-2)" "unprognostic (2.49e-2)" "unprognostic (1.13e-1)" "unprognostic (4.37e-2)" "unprognostic (2.01e-1)" 3.8 2.1 7.1 2.8 10.6 10.2 6.6 10.3 8.3 6.4 4.8 5.3 8.6 3.2 3.7 7.1 3.0 2.6 2.4 7.3 8.0 2.5 6.9 3.9 3.9 10.8 10.1 9.8 3.6 3.4 2.4 3.5 10.3 15.5 7.0 2.8 8.4 2.6 8.3 12.7 10.8 2.9 8.5 5.3 4.5 9.6 9.9 4.2 3.4 4.7 5.2 4.7 7.4 15.1 1.9 0.0 0.9 0.1 3.5 1.8 14.6 0.7 4.9 2.1 3.6 4.3 1.7 6.2 0.6 1.8 5.4 2.3 3.9 3.1 1.6 4.4 4.9 4.2 2.0 3.2 1.9 1.4 11.1 1.9 3.2 2.4 3.4 3.2 1.7 8.1 0.8 12.4 1.4 0.7 3.6 2.9 3.8 1.8 1.8 5.2 0.1 1.5 1.9 14.7 0.4 1.6 3.8 7.3 14.1 8.6 11.3 1.8 0.0 0.2 2.1 1.3 1.3 8.0 5.0 1.2 1.1 0.0 1.0 12.8 4.6 13.3 2.7 3.4 1.9 8.0 2.5 1.8 2.4 6.6 4.1 2.3 19.0 1.5 8.0 1.3 1.9 3.4 7.1 10.6 10.3 8.3 7.3 8.0 10.8 10.1 10.3 8.5 9.9 15.1 3.9 0.0 2.8 54.2 10.7 7.8 7.1 2.8 14.2 2.4 11.9 9.4 1.3 4.3 3.4 0.0 14.6 8.3 4.2 13.9 0.0 1.3 23.7 4.6 1.8 3.2 4.2 5.0 10.2 2.7 2.8 3.7 7.7 8.9 7.0 2.4 2.2 6.3 6.8 0.0 6.7 6.9 4.1 5.5 4.4 7.8 2.8 6.0 3.6 15.9 4.6 1.1 4.1 18.6 222.9 1.1 7.3 1.9 9.8 10.6 14.9 1.2 2.0 3.1 6.6 2.6 6.1 22.0 13.6 12.6 8.5 14.8 4.7 1.8 4.9 8.0 TGFBR1 "ACVRLK4, ALK-5, ALK5, ESS1, MSSE, TBR-i, TBRI" ENSG00000106799 "Transforming growth factor beta receptor 1" P36897 9 99104038-99154192 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Differentiation, Growth regulation" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Aortic aneurysm, Craniosynostosis, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 128.4;Late spermatids: 101.7;Microglial cells: 116.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RH-30: 253.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002441, CAB031481, HPA056473" Uncertain Supported "Plasma membrane" "Intracellular and membrane" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 65: Plasmacytoid DCs - Unknown function" "Plasma membrane" "CAB002441: AB_564029, CAB031481: AB_2202455, HPA056473: AB_2683144" "unprognostic (2.58e-3)" "unprognostic (1.20e-2)" "unprognostic (3.64e-3)" "unprognostic (2.80e-1)" "unprognostic (8.63e-2)" "unprognostic (3.36e-2)" "unprognostic (1.97e-2)" "unprognostic (1.32e-3)" "unprognostic (1.97e-1)" "unprognostic (1.45e-1)" "unprognostic (8.21e-3)" "unprognostic (1.82e-1)" "unprognostic (1.18e-1)" "unprognostic (1.01e-3)" "unprognostic (3.40e-2)" "unprognostic (3.19e-2)" "unprognostic (1.14e-2)" 15.9 9.9 9.8 18.2 9.3 33.7 15.4 13.2 8.9 19.4 11.8 18.8 11.7 20.6 8.8 15.0 8.5 21.7 8.2 6.8 11.3 22.6 14.8 16.3 13.8 18.4 14.5 13.0 8.3 8.5 7.6 48.8 20.0 17.1 13.4 4.7 8.3 16.8 8.7 6.2 9.3 33.0 18.0 16.5 18.4 18.3 17.5 11.2 11.2 13.2 13.6 22.5 8.4 27.9 13.7 19.5 115.5 36.1 26.2 19.3 17.4 44.1 47.8 40.7 44.9 19.9 9.3 29.7 13.4 34.6 32.1 30.4 39.6 34.1 54.0 77.1 12.3 43.9 20.7 17.8 43.2 27.2 102.8 40.2 35.4 62.8 29.5 25.2 7.4 10.9 62.4 12.1 55.4 20.3 4.0 31.0 24.7 12.2 11.5 11.0 253.1 12.5 9.9 3.8 31.1 36.2 34.3 150.2 46.4 47.3 28.1 36.6 13.6 29.8 25.5 129.3 27.3 12.1 13.4 20.0 62.5 45.9 26.2 16.2 2.4 9.5 7.8 1.6 6.7 1.6 3.3 5.8 2.0 1.2 3.2 6.2 4.9 4.3 2.0 1.4 2.4 2.2 9.8 9.3 13.2 8.9 6.8 11.3 18.4 14.5 20.0 18.0 17.5 27.9 13.5 6.4 8.8 18.9 18.9 23.6 7.4 19.9 44.3 8.0 18.9 11.7 7.6 4.3 12.8 60.7 0.0 23.0 37.3 5.0 0.0 18.8 128.4 6.4 22.7 17.6 9.6 7.4 14.2 31.2 6.7 36.0 9.2 9.3 29.9 19.5 6.4 12.7 49.4 0.0 8.6 7.3 8.2 32.4 52.5 101.7 9.6 39.7 35.6 116.2 24.3 3.1 35.0 45.8 21.1 33.8 4.2 13.5 11.9 18.4 3.6 13.8 5.0 2.0 32.9 21.8 20.9 11.0 12.7 25.6 16.2 19.4 25.4 7.6 8.3 11.5 TGFBR2 "MFS2, TBR-ii, TBRII" ENSG00000163513 "Transforming growth factor beta receptor 2" P37173 3 30606601-30694142 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Apoptosis, Differentiation, Growth regulation" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Aortic aneurysm, Cancer-related genes, Craniosynostosis, Disease variant, FDA approved drug targets, Hereditary nonpolyposis colorectal cancer" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 391.5;Endothelial cells: 236.4;Hepatic stellate cells: 478.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC diff: 313.6;ASC TERT1: 472.3;HSkMC: 430.0;LHCN-M2: 381.7;TIME: 418.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB073537 Supported "Plasma membrane" NA NA 810000 "Cluster 5: Granulocytes - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Plasma membrane" "CAB073537: " "unprognostic (1.74e-1)" "unprognostic (1.84e-2)" "unprognostic (3.70e-1)" "unprognostic (3.02e-2)" "unprognostic (1.92e-1)" "unprognostic (2.26e-1)" "unprognostic (1.96e-1)" "unprognostic (1.62e-1)" "unprognostic (1.40e-1)" "unprognostic (2.24e-2)" "unprognostic (7.36e-2)" "unprognostic (1.12e-1)" "unprognostic (1.65e-2)" "unprognostic (4.72e-2)" "unprognostic (1.81e-2)" "unprognostic (8.81e-2)" "unprognostic (8.02e-2)" 230.0 56.1 16.5 73.8 12.9 29.4 145.7 13.8 19.3 90.0 30.6 96.0 44.2 69.1 18.2 44.9 69.6 91.9 95.2 10.6 13.4 67.9 59.1 148.0 70.1 17.6 16.5 26.6 52.0 59.0 16.9 81.6 16.7 44.1 54.1 2.1 49.2 60.8 31.1 39.1 77.7 107.2 17.3 111.1 63.4 7.8 21.5 49.7 91.8 62.2 60.7 98.0 55.1 17.2 16.6 100.2 5.3 0.1 313.6 472.3 15.9 83.9 116.1 28.5 27.7 22.9 86.6 2.2 298.2 117.2 32.2 33.3 4.0 125.4 42.0 7.0 8.9 10.1 10.7 104.5 128.5 14.9 76.6 430.0 93.6 126.3 114.4 117.0 296.0 10.9 1.8 0.0 381.7 1.3 16.2 10.5 2.2 75.7 39.8 14.1 36.4 2.1 113.5 40.5 0.1 5.6 24.9 6.1 22.0 6.6 0.0 14.0 418.6 134.7 33.2 61.4 32.0 2.8 0.3 12.5 80.1 16.1 55.8 9.0 3.0 11.5 3.4 3.1 3.3 4.5 4.8 3.3 2.6 6.4 16.6 7.3 13.1 1.9 8.0 6.6 0.7 3.8 16.5 12.9 13.8 19.3 10.6 13.4 17.6 16.5 16.7 17.3 21.5 17.2 391.5 144.2 99.7 0.7 77.0 37.3 18.9 23.5 39.9 5.1 23.7 24.1 84.5 50.1 39.5 27.6 0.0 6.8 85.3 10.5 3.9 13.1 2.5 28.3 57.5 236.4 8.4 20.4 0.4 15.8 5.1 129.2 39.3 30.8 29.8 0.7 478.0 55.5 30.4 0.0 1.0 12.4 22.4 147.0 58.0 3.8 32.9 67.9 30.2 170.5 47.5 0.2 56.7 6.0 2.4 37.6 12.1 47.4 37.5 8.6 13.6 7.2 14.7 1.2 32.9 60.8 53.4 0.3 1.2 8.0 30.5 3.7 68.2 1.7 14.5 10.8 TGM1 "ICR2, LI, LI1, TGASE, TGK" ENSG00000092295 "Transglutaminase 1" P22735 14 24249114-24264432 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Keratinization "Acyltransferase, Transferase" "Disease variant, Ichthyosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "esophagus: 713.5" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 12.8;Basal respiratory cells: 63.6;Club cells: 18.8;Distal tubular cells: 29.4;Squamous epithelial cells: 34.7" "Group enriched" "Detected in many" 4 "cervical cancer: 30.8;head and neck cancer: 78.3" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 17.5;HaCaT: 24.2;HeLa: 16.2;MCF7: 17.5;SK-BR-3: 21.7" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB015159, HPA040171, HPA070372" Enhanced Approved "Vesicles,Plasma membrane" NA NA 530000 "Cluster 84: Esophagus - Epithelial cell function" "Cluster 28: BEWO - Transcription regulation" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Vesicles, Plasma membrane" "CAB015159: AB_2202870, HPA040171: AB_2676869, HPA070372: " "unprognostic (2.95e-2)" "unprognostic (8.79e-2)" "unprognostic (2.92e-2)" "unprognostic (1.89e-2)" "unprognostic (2.36e-1)" "unprognostic (1.10e-1)" "unprognostic (4.04e-2)" "unprognostic (1.12e-2)" "unprognostic (2.39e-1)" "unprognostic (3.01e-2)" "unprognostic (6.72e-2)" "unprognostic (2.15e-1)" "unprognostic (1.94e-7)" "unprognostic (7.11e-2)" "unprognostic (7.38e-2)" "unprognostic (2.22e-3)" "unprognostic (1.86e-2)" 25.7 1.3 0.6 0.9 0.8 0.7 2.2 3.7 2.0 78.7 0.8 1.4 0.8 1.0 1.6 713.5 4.4 0.6 5.1 0.5 0.6 2.5 1.7 5.3 1.5 1.5 0.9 3.0 3.2 0.2 3.3 1.2 1.4 4.1 0.9 1.7 89.7 4.4 1.1 73.2 1.9 0.5 0.4 2.6 1.8 2.9 0.9 1.3 2.7 0.3 40.4 1.3 144.2 0.9 1.1 2.0 1.1 1.0 0.0 0.8 17.5 0.4 0.2 1.0 1.6 1.2 1.7 1.0 2.3 1.3 0.3 24.2 2.8 2.0 0.6 2.0 3.3 1.4 16.2 5.7 0.8 0.9 1.5 1.5 9.3 0.5 2.0 0.5 0.7 3.4 1.0 1.0 0.7 17.5 0.7 1.9 0.3 1.1 2.2 1.1 0.1 1.1 0.6 2.1 1.2 1.6 0.2 21.7 0.1 1.4 1.5 1.1 0.8 1.1 4.8 2.0 0.9 1.5 1.8 0.3 0.4 2.1 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.8 3.7 2.0 0.5 0.6 1.5 0.9 1.4 0.4 0.9 0.9 0.2 12.8 1.1 2.0 0.0 0.3 4.6 63.6 4.0 0.9 1.1 0.8 0.8 5.7 18.8 0.0 0.0 1.4 0.3 0.2 29.4 2.0 0.1 0.3 0.2 0.2 0.0 0.0 1.5 0.9 0.8 3.9 0.0 0.6 4.5 0.7 0.0 0.2 0.4 0.0 1.7 0.1 6.1 0.6 0.3 0.0 0.6 0.4 0.0 1.0 0.4 0.2 0.0 1.0 1.0 2.6 0.0 0.4 0.1 7.4 0.1 0.2 2.1 0.6 0.0 0.1 1.0 0.0 0.6 34.7 1.8 1.2 0.6 1.2 0.3 6.2 TGM2 TGC ENSG00000198959 "Transglutaminase 2" P21980 20 38127385-38166578 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Acyltransferase, Hydrolase, Protease, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "cervix: 432.0" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 204.5;Cytotrophoblasts: 311.1;Ductal cells: 226.7;Endometrial stromal cells: 459.1;Hepatic stellate cells: 408.0;Hepatocytes: 205.7;Pancreatic endocrine cells: 326.5;Syncytiotrophoblasts: 374.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 4 "CAPAN-2: 1546.7;EFO-21: 505.5;hTERT-RPE1: 994.3;HUVEC TERT2: 695.3;TIME: 924.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002598, HPA021019, HPA029518" Enhanced Approved "Plasma membrane,Cytosol" "Secreted to extracellular matrix" Yes No 1700000 "Cluster 43: B-cells - Humoral immune response" "Cluster 46: Fibroblasts - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 36: Stromal cells - Cell proliferation" Cytosol "Plasma membrane" "CAB002598: , HPA021019: AB_1858247, HPA029518: AB_10603133" "unprognostic (7.80e-2)" "unprognostic (1.51e-1)" "unprognostic (5.22e-2)" "unprognostic (1.40e-2)" "unprognostic (1.56e-2)" "unprognostic (5.61e-3)" "unprognostic (2.81e-1)" "unprognostic (3.32e-3)" "unprognostic (3.29e-2)" "unprognostic (9.78e-3)" "prognostic unfavorable (2.97e-4)" "unprognostic (6.99e-2)" "prognostic unfavorable (1.67e-7)" "unprognostic (1.60e-2)" "unprognostic (1.93e-2)" "unprognostic (6.70e-2)" "unprognostic (6.40e-2)" 105.9 45.1 23.0 68.4 22.3 3.2 30.3 22.9 29.5 432.0 53.0 30.6 29.8 266.3 28.3 37.3 217.7 127.7 394.9 21.4 23.0 76.7 244.1 288.5 18.0 25.4 22.5 40.6 25.6 19.3 95.9 234.3 26.0 88.7 20.8 2.1 9.8 56.6 63.9 4.0 63.7 159.0 24.4 32.7 62.3 3.9 30.6 15.4 36.3 33.4 10.3 154.2 87.8 24.8 65.0 47.5 0.2 1.8 47.3 5.1 24.0 95.5 45.2 0.7 1.8 78.4 1546.7 0.1 505.5 1.0 105.4 1.7 0.1 221.7 3.4 0.7 0.2 10.3 2.6 35.0 191.9 0.0 0.5 5.2 0.4 40.2 0.3 994.3 695.3 0.0 21.4 0.1 16.0 0.3 0.0 0.6 0.8 0.9 4.6 0.0 0.1 0.3 69.0 0.0 0.0 1.3 224.4 0.2 7.6 31.6 2.2 0.6 924.2 1.6 57.6 7.8 46.3 0.0 0.6 0.8 60.7 0.1 18.4 0.0 0.0 0.0 0.0 0.6 0.0 0.4 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 23.0 22.3 22.9 29.5 21.4 23.0 25.4 22.5 26.0 24.4 30.6 24.8 58.0 9.6 18.3 0.0 7.4 0.5 10.4 41.0 0.6 0.0 8.5 8.8 204.5 31.5 55.3 14.7 2.1 311.1 0.1 11.7 3.9 226.7 3.2 16.7 459.1 183.8 0.0 74.5 0.1 145.7 38.6 37.7 0.5 13.1 2.5 2.8 408.0 205.7 54.4 0.0 0.1 1.8 6.1 23.7 2.1 5.0 1.2 35.5 0.0 28.1 6.5 0.4 0.0 0.0 0.3 326.5 1.1 6.0 0.0 68.6 63.0 27.6 23.6 0.5 0.0 5.2 49.1 0.4 4.0 0.9 0.0 374.2 3.9 2.1 3.3 26.4 TGM3 TGE ENSG00000125780 "Transglutaminase 3" Q08188 20 2296001-2341079 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Keratinization "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "esophagus: 1838.1" "Group enriched" "Detected in some" 4 "Enteroendocrine cells: 46.2;Squamous epithelial cells: 22.5" "Cancer enriched" "Detected in many" 9 "head and neck cancer: 81.6" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 295 "neutrophil: 30.3" "Lineage enriched" "Detected in single" 303 "granulocytes: 30.3" "Cell line enriched" "Detected in single" 14 "EFO-21: 5.2" HPA004728 Approved NA NA 14000000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 38: EFO-21 - Unknown function" "Cluster 61: Squamous epithelial cells - Keratinization" "HPA004728: AB_1080360" "unprognostic (7.14e-2)" "unprognostic (8.93e-2)" "unprognostic (2.18e-2)" "unprognostic (3.23e-3)" "unprognostic (4.27e-2)" "unprognostic (4.20e-2)" "unprognostic (8.62e-2)" "unprognostic (4.21e-2)" "unprognostic (1.50e-1)" "unprognostic (8.00e-2)" "unprognostic (4.88e-3)" "unprognostic (1.35e-1)" "unprognostic (7.78e-8)" "unprognostic (1.56e-1)" "unprognostic (1.61e-1)" "unprognostic (1.45e-2)" "unprognostic (9.67e-2)" 0.6 0.3 0.2 0.2 0.0 1.4 3.9 0.0 0.1 54.3 0.0 0.3 0.0 0.2 0.8 1838.1 1.4 2.2 0.4 0.2 0.0 0.2 0.8 0.5 0.0 0.1 0.3 0.3 1.1 0.0 1.6 0.1 0.1 0.6 0.8 0.0 229.3 0.0 0.4 83.1 0.4 0.0 0.1 0.4 2.2 2.0 0.0 0.1 0.1 0.0 142.9 0.3 31.4 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 5.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 30.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.2 0.0 0.1 0.3 0.1 0.1 0.0 0.0 0.0 0.0 0.6 0.3 0.0 1.7 0.0 0.0 0.0 0.0 0.4 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.1 1.9 4.0 0.1 0.1 46.2 0.0 0.4 0.0 0.0 0.3 0.0 0.2 0.0 0.9 0.0 0.0 0.0 0.0 0.2 3.7 0.0 0.0 0.3 4.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.3 0.0 0.0 3.2 0.0 0.0 0.0 0.1 1.2 0.5 22.5 8.2 0.0 0.0 0.1 0.3 0.2 TGM4 TGP ENSG00000163810 "Transglutaminase 4" P49221 3 44874608-44914990 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 377 "prostate: 434.4" "Cell type enriched" "Detected in some" 20 "Prostatic glandular cells: 226.6" "Cancer enriched" "Detected in single" 312 "prostate cancer: 75.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 4.9;hTERT-HME1: 1.3;NB-4: 2.7;RPMI-8226: 2.0;SH-SY5Y: 1.4" "Not detected" "Not detected" "CAB033571, HPA073290" Enhanced NA NA "Cluster 51: Non-specific - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 35: Glandular cells - Unknown function" "CAB033571: AB_2287329, HPA073290: " "unprognostic (4.40e-2)" "unprognostic (4.68e-2)" "unprognostic (1.92e-1)" "unprognostic (2.17e-3)" "unprognostic (2.84e-1)" "unprognostic (2.19e-2)" "unprognostic (1.37e-1)" "unprognostic (1.92e-1)" "unprognostic (2.41e-2)" "unprognostic (1.65e-1)" "unprognostic (8.56e-3)" "unprognostic (5.08e-2)" "unprognostic (1.44e-8)" "unprognostic (1.10e-1)" "unprognostic (1.98e-2)" "unprognostic (3.68e-1)" "unprognostic (6.41e-2)" 0.0 1.1 0.0 0.2 0.0 0.5 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 434.4 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 1.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.1 0.0 0.0 2.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.8 0.3 0.0 0.3 0.3 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.4 0.5 4.2 0.7 0.0 0.0 0.1 0.1 0.9 0.0 0.2 0.0 0.0 0.5 0.2 0.1 0.0 0.0 5.7 0.8 0.6 0.4 0.0 0.0 0.2 0.0 0.3 1.3 0.0 1.5 0.0 0.0 0.4 0.0 0.1 0.0 0.3 0.2 0.0 0.0 0.0 11.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.2 0.0 0.4 0.0 226.6 0.0 0.0 0.0 0.0 0.0 1.0 0.3 0.1 0.3 0.0 0.4 1.0 0.2 0.1 0.2 2.4 TGM5 "TGMX, TGX" ENSG00000104055 "Transglutaminase 5" O43548 15 43232590-43266928 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Acyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "esophagus: 12.0;skin 1: 39.3" "Cell type enhanced" "Detected in some" "Basal prostatic cells: 2.6;Club cells: 4.3;Early spermatids: 3.2;Late spermatids: 4.0;Suprabasal keratinocytes: 6.7;Urothelial cells: 12.1" "Cancer enhanced" "Detected in many" "head and neck cancer: 2.2" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 7 "HEL: 16.6" "Region enriched" "Detected in single" 12 "cerebellum: 2.6" "Low region specificity" "Detected in many" NA NA "Cluster 31: Skin - Epidermis development" "Cluster 36: HEL - Hemostasis" "Cluster 22: Epithelial cell types - Mixed function" "unprognostic (3.17e-2)" "unprognostic (1.03e-2)" "unprognostic (5.92e-2)" "unprognostic (2.65e-1)" "unprognostic (2.24e-2)" "unprognostic (1.94e-2)" "unprognostic (1.78e-1)" "unprognostic (7.68e-2)" "unprognostic (2.25e-2)" "unprognostic (1.77e-1)" "unprognostic (1.44e-15)" "unprognostic (1.94e-1)" "unprognostic (3.14e-1)" "unprognostic (7.22e-3)" "unprognostic (5.71e-2)" 0.8 0.0 0.0 0.0 0.0 0.2 1.7 0.2 0.0 3.9 0.0 0.0 0.0 0.0 0.0 12.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.2 0.0 0.0 0.0 0.1 0.0 0.2 1.0 0.0 0.0 4.3 1.2 0.3 39.3 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.2 0.0 0.0 2.3 0.5 7.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 16.6 0.0 0.3 0.0 0.7 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.1 0.0 2.4 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.4 0.2 0.2 0.3 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.9 2.6 1.5 0.0 0.0 1.0 0.5 0.2 0.0 4.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 3.2 0.4 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.2 0.0 1.3 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.4 4.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 2.1 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.1 0.2 0.8 6.7 1.9 0.0 0.0 0.0 12.1 TGM6 "dJ734P14.3, SCA35, TGM3L, TGY" ENSG00000166948 "Transglutaminase 6" O95932 20 2380901-2432753 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Acyltransferase, Transferase" "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in single" 10 "cerebellum: 1.0" HPA059196 Uncertain NA NA "HPA059196: AB_2683943" "unprognostic (1.18e-1)" "unprognostic (2.84e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TGM7 TGMZ ENSG00000159495 "Transglutaminase 7" Q96PF1 15 43276271-43302255 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in single" "lymphoid tissue: 1.6" "Group enriched" "Detected in some" 11 "Early spermatids: 62.0;Late spermatids: 16.7" "Cancer enriched" "Detected in single" 13 "endometrial cancer: 2.1" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 35 "EFO-21: 3.5" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 16: Immune cells - Immune response" "Cluster 38: EFO-21 - Unknown function" "Cluster 29: Early spermatids - Spermatogenesis" "unprognostic (2.45e-2)" "unprognostic (2.04e-1)" "unprognostic (2.82e-2)" "unprognostic (1.71e-2)" "unprognostic (1.07e-1)" "unprognostic (2.01e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 1.6 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.1 0.0 0.0 0.4 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 62.0 0.3 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 16.7 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.8 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 3.5 TGS1 "NCOA6IP, PIMT" ENSG00000137574 "Trimethylguanosine synthase 1" Q96RS0 8 55773446-55826445 "Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA025024, HPA029824" Supported Supported Cytosol NA NA "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" Cytosol "HPA025024: AB_1854330, HPA029824: AB_2673212" "unprognostic (4.13e-2)" "unprognostic (7.46e-2)" "unprognostic (6.64e-2)" "prognostic unfavorable (4.63e-4)" "unprognostic (2.11e-1)" "unprognostic (2.47e-1)" "unprognostic (3.70e-2)" "unprognostic (1.60e-2)" "unprognostic (4.94e-2)" "unprognostic (9.32e-2)" "unprognostic (3.15e-2)" "unprognostic (3.58e-1)" "unprognostic (2.22e-2)" "unprognostic (8.62e-2)" "unprognostic (7.23e-2)" "unprognostic (3.42e-1)" "unprognostic (2.85e-2)" 5.9 4.0 1.8 5.0 1.4 7.2 5.5 3.8 2.3 5.0 2.5 4.9 3.1 5.9 4.1 5.7 5.8 4.1 3.5 1.5 1.5 5.5 4.0 4.5 8.5 1.2 1.3 6.0 4.0 6.8 4.0 4.2 1.3 4.5 4.6 2.5 4.9 5.7 7.4 6.4 5.5 4.6 1.1 5.7 4.5 4.9 1.6 9.5 5.4 2.6 8.5 7.3 5.1 1.9 12.0 9.0 10.2 12.7 9.7 8.2 10.3 10.9 11.6 11.9 12.3 8.5 10.7 27.7 7.0 8.5 8.5 10.8 24.3 14.7 16.3 17.2 8.7 31.6 10.6 5.1 13.1 16.8 9.4 9.7 10.1 11.4 22.7 5.2 9.5 16.0 24.8 9.9 9.6 9.4 36.0 10.6 35.0 16.8 3.6 26.4 7.1 8.2 10.6 12.0 10.6 13.3 19.4 8.0 10.4 10.5 10.9 9.7 9.7 8.4 10.6 9.8 10.4 8.5 6.3 32.1 8.5 13.6 11.3 5.0 2.7 4.3 5.1 2.8 6.0 4.6 4.8 4.7 2.4 4.8 5.2 5.2 3.4 3.3 3.9 5.2 4.2 2.6 1.8 1.4 3.8 2.3 1.5 1.5 1.2 1.3 1.3 1.1 1.6 1.9 29.8 48.1 35.2 15.7 41.6 37.0 36.8 25.7 35.3 30.6 21.8 34.7 15.5 20.0 37.9 51.5 22.9 29.6 30.4 10.8 3.9 20.3 3.7 28.2 42.6 27.2 10.7 49.2 28.9 25.2 26.7 32.4 23.4 27.6 50.0 24.3 20.7 17.2 20.3 21.9 30.0 23.3 16.2 16.8 12.2 4.6 29.5 22.2 7.2 12.2 26.1 27.7 29.9 34.7 19.9 22.2 12.1 23.0 32.7 42.3 10.9 17.7 25.5 29.5 26.3 40.5 25.7 88.2 78.3 33.5 26.1 22.4 41.2 35.2 22.5 31.9 THOP1 ENSG00000172009 "Thimet oligopeptidase 1" P52888 19 2785503-2815807 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 136.6;Paneth cells: 160.6;Proximal enterocytes: 312.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025497, HPA035262" Uncertain Supported Cytosol NA NA 2000000 "Cluster 18: Basophils - Vesicular transport" "Cluster 43: Testis - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 45: Enterocytes - Digestion" Cytosol "CAB025497: , HPA035262: AB_2674541" "unprognostic (1.52e-2)" "unprognostic (1.73e-3)" "unprognostic (7.94e-2)" "prognostic favorable (2.35e-4)" "unprognostic (1.82e-1)" "unprognostic (2.16e-2)" "unprognostic (9.35e-2)" "unprognostic (1.19e-1)" "unprognostic (4.05e-2)" "unprognostic (1.43e-1)" "unprognostic (1.20e-3)" "unprognostic (3.00e-2)" "unprognostic (1.39e-1)" "prognostic favorable (5.90e-4)" "unprognostic (1.27e-1)" "unprognostic (2.64e-1)" "unprognostic (5.37e-2)" 13.4 19.6 31.8 11.8 31.6 19.6 15.3 29.8 48.4 15.3 25.4 21.3 22.6 18.7 6.3 31.0 17.6 3.3 38.0 33.2 28.7 22.7 73.0 13.7 11.6 33.7 31.7 18.8 17.5 6.0 32.0 7.8 30.7 37.6 7.0 9.3 15.7 5.2 40.6 20.0 21.5 6.1 26.9 23.0 16.1 70.2 28.6 13.8 17.9 11.0 8.3 18.7 15.9 30.4 91.4 66.3 25.1 54.6 12.8 12.5 89.9 55.4 20.4 53.8 43.4 78.4 28.3 81.3 26.4 21.7 37.7 72.4 37.8 45.6 22.5 0.3 79.7 28.9 75.9 94.4 13.7 56.3 43.1 13.9 16.0 44.8 20.0 15.5 31.0 54.0 68.2 38.7 23.1 70.5 63.1 105.0 74.7 27.2 90.2 51.7 33.8 77.5 22.8 51.9 68.5 54.6 48.5 42.9 27.6 13.1 41.8 53.8 35.5 41.2 35.5 88.6 95.4 67.1 60.7 55.7 46.0 93.3 50.1 9.3 2.5 1.2 3.7 2.9 3.0 3.8 2.7 5.2 3.6 5.3 3.4 3.0 1.0 3.0 6.0 7.0 7.6 2.5 31.8 31.6 29.8 48.4 33.2 28.7 33.7 31.7 30.7 26.9 28.6 30.4 5.1 3.2 10.6 15.0 12.0 6.8 10.3 15.6 11.4 20.3 12.6 10.8 9.0 5.7 9.7 11.0 35.5 27.6 8.7 136.6 9.8 18.7 17.6 11.1 8.3 7.4 40.8 13.7 12.1 15.1 55.9 11.1 9.2 10.1 5.7 23.1 7.1 85.9 23.0 6.7 10.5 59.9 6.1 9.8 6.0 23.4 11.5 9.1 3.6 3.7 8.3 13.5 4.1 4.0 7.1 21.3 160.6 6.0 17.2 16.6 312.2 10.8 9.7 32.4 13.1 10.6 15.0 55.6 19.2 13.4 5.8 33.8 8.0 15.9 48.2 8.4 TIPARP "ARTD14, DDF1, DKFZP434J214, DKFZp686N0351, PARP-1, PARP-7, PARP7, pART14, RM1" ENSG00000163659 "TCDD inducible poly(ADP-ribose) polymerase" Q7Z3E1 3 156673235-156706770 "Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 302.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 53.5" "Lineage enriched" "Detected in all" 5 "granulocytes: 53.5" "Cell line enhanced" "Detected in all" "HBEC3-KT: 168.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036796 Approved Microtubules NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 23: Testis - Cell cycle regulation" "Cluster 30: Epithelial cell lines - Translation" "Cluster 50: Fibroblasts - ECM organization" Microtubules "HPA036796: AB_10672268" "prognostic favorable (2.00e-5)" "unprognostic (3.50e-1)" "unprognostic (7.62e-2)" "unprognostic (5.21e-2)" "unprognostic (2.62e-1)" "unprognostic (4.56e-2)" "unprognostic (9.50e-2)" "unprognostic (3.57e-2)" "unprognostic (2.23e-1)" "unprognostic (1.43e-1)" "unprognostic (4.27e-3)" "unprognostic (2.01e-1)" "unprognostic (4.69e-2)" "unprognostic (7.26e-2)" "unprognostic (1.73e-1)" "unprognostic (6.16e-3)" "unprognostic (4.90e-3)" 67.5 56.6 16.5 16.0 19.3 74.1 39.7 17.7 22.3 29.8 15.2 15.1 13.5 30.6 14.7 55.1 39.5 27.9 34.6 16.4 21.2 28.2 44.3 27.4 13.7 33.4 27.9 40.2 29.6 99.2 15.1 12.5 22.9 25.9 14.4 18.3 10.3 27.8 17.6 39.5 23.1 43.7 19.9 10.9 21.9 50.3 25.7 21.7 17.0 9.6 18.1 65.0 24.0 21.9 42.8 29.6 9.8 8.4 35.7 25.9 8.0 70.0 56.4 34.9 48.2 17.2 86.9 12.7 22.2 79.9 46.5 42.1 25.1 168.0 51.4 27.3 18.5 21.0 29.0 11.7 15.2 7.4 38.1 21.3 103.0 35.6 84.9 93.8 32.3 9.4 16.9 49.9 122.5 8.2 6.4 9.8 11.2 53.5 24.5 10.5 22.5 43.6 36.7 20.1 29.5 7.5 55.2 16.9 11.9 22.5 26.2 12.5 70.2 15.1 4.9 28.5 25.1 53.9 10.6 11.3 25.7 11.3 51.4 53.5 5.0 7.5 6.1 3.3 8.6 2.9 5.9 8.2 3.6 5.4 3.6 4.9 15.9 11.6 9.2 5.0 7.4 3.3 16.5 19.3 17.7 22.3 16.4 21.2 33.4 27.9 22.9 19.9 25.7 21.9 112.8 86.6 98.3 27.7 43.9 196.0 117.3 51.7 185.5 5.0 62.0 57.7 29.9 31.5 66.5 7.3 39.6 5.1 97.0 38.3 21.5 35.2 302.3 114.6 118.7 45.6 54.5 7.0 3.6 23.5 10.3 109.0 57.6 169.4 115.0 12.2 20.3 18.9 19.2 21.9 8.7 32.4 18.3 18.5 97.5 28.0 19.6 101.7 37.4 12.2 17.3 10.1 16.5 22.1 20.4 36.9 40.1 19.2 60.5 83.9 40.4 16.2 43.5 10.4 13.1 138.0 87.7 58.0 33.4 100.1 121.5 7.5 105.4 7.3 18.2 187.8 TLK1 "KIAA0137, PKU-BETA" ENSG00000198586 "Tousled like kinase 1" Q9UKI8 2 170990823-171231314 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, DNA damage" "Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016043 Approved Supported Nucleoplasm NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "HPA016043: AB_1858027" "unprognostic (2.13e-2)" "unprognostic (3.87e-1)" "unprognostic (7.36e-2)" "unprognostic (6.00e-3)" "unprognostic (2.00e-1)" "unprognostic (6.78e-2)" "unprognostic (2.47e-2)" "unprognostic (7.60e-2)" "unprognostic (1.61e-1)" "unprognostic (5.26e-2)" "unprognostic (2.57e-1)" "unprognostic (1.11e-1)" "unprognostic (6.13e-2)" "unprognostic (2.08e-1)" "unprognostic (1.55e-1)" "unprognostic (2.63e-1)" "unprognostic (1.53e-1)" 7.7 10.2 5.9 10.7 8.3 11.1 12.3 4.1 10.5 12.7 5.1 13.0 9.4 10.6 5.4 9.4 9.5 9.6 7.0 10.1 4.6 13.0 14.8 8.4 15.0 3.5 7.3 14.0 10.4 18.0 6.2 15.2 3.4 11.8 12.3 15.8 9.2 14.6 16.3 8.5 11.8 11.7 4.4 13.2 13.5 17.7 10.6 13.8 17.6 5.5 15.7 11.7 8.3 7.6 16.6 15.6 22.0 17.3 15.4 15.3 24.7 22.5 31.9 21.8 18.2 21.8 25.9 34.2 18.7 33.4 23.6 13.7 28.5 24.6 23.8 42.1 14.9 39.1 18.5 28.0 16.5 50.3 19.0 16.7 24.6 43.4 28.4 23.0 24.3 21.2 42.3 27.4 13.2 20.3 43.8 15.5 20.6 15.5 8.9 31.9 26.9 34.7 17.7 30.9 25.0 19.7 24.7 16.7 16.1 14.9 13.8 17.0 33.2 19.3 24.0 12.7 17.8 24.5 43.0 59.7 23.9 20.1 19.9 11.1 3.1 5.7 5.2 2.6 7.3 8.3 8.3 5.7 3.0 8.3 9.3 6.2 4.2 8.1 5.3 4.4 8.5 5.2 5.9 8.3 4.1 10.5 10.1 4.6 3.5 7.3 3.4 4.4 10.6 7.6 34.2 51.3 27.8 135.8 76.7 41.3 33.2 27.1 30.7 34.8 45.9 28.4 32.1 37.1 29.2 51.5 60.5 82.7 42.6 55.8 88.0 29.2 58.1 29.5 33.9 34.5 23.9 33.7 196.2 32.7 52.7 30.3 37.8 38.4 27.3 39.5 27.5 40.0 27.4 45.4 161.0 36.7 36.7 29.0 30.4 32.0 43.2 54.7 37.4 74.0 29.1 26.6 49.4 84.9 92.0 35.6 36.5 44.8 66.3 51.0 33.4 58.0 30.7 77.5 0.0 41.6 29.6 31.1 54.9 24.5 39.1 174.9 66.4 59.2 33.9 43.0 TLK2 "MGC44450, PKU-ALPHA" ENSG00000146872 "Tousled like kinase 2" Q86UE8 17 62458658-62615481 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, DNA damage" "Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 173.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 25: Spermatids - Spermatogenesis" "unprognostic (2.50e-2)" "unprognostic (2.12e-1)" "unprognostic (7.06e-2)" "unprognostic (1.48e-2)" "unprognostic (9.53e-3)" "unprognostic (6.57e-2)" "prognostic unfavorable (9.40e-4)" "unprognostic (4.53e-2)" "unprognostic (5.28e-2)" "unprognostic (2.32e-1)" "unprognostic (2.82e-2)" "unprognostic (4.78e-2)" "unprognostic (5.32e-2)" "unprognostic (9.79e-2)" "unprognostic (4.32e-2)" "unprognostic (4.88e-1)" "unprognostic (7.30e-2)" 19.9 16.9 7.5 21.1 14.9 36.1 11.8 19.8 12.0 12.4 9.5 21.7 20.5 22.9 8.7 23.6 13.2 20.9 22.6 9.8 17.5 15.2 12.5 16.2 25.5 18.1 14.2 21.6 18.0 16.0 9.8 17.4 14.4 16.0 14.8 43.4 16.5 11.4 32.4 23.7 20.5 16.1 10.0 21.4 18.6 52.1 12.8 23.2 30.0 21.8 17.2 19.1 10.9 25.5 40.9 36.9 62.2 66.4 20.3 26.0 36.6 44.1 34.4 51.7 46.6 39.0 35.7 79.0 22.0 29.2 45.1 27.2 45.1 19.0 48.9 42.3 36.1 54.2 33.6 39.2 36.2 57.9 33.1 22.7 25.4 34.7 41.7 31.2 25.9 44.9 54.4 36.0 28.3 89.2 82.7 22.0 39.8 24.4 30.9 55.9 81.8 25.7 24.9 40.7 66.9 90.6 37.6 25.5 57.1 52.0 43.2 51.8 34.9 71.2 66.9 32.5 50.6 40.1 54.5 72.3 29.4 29.1 38.2 2.5 1.4 4.9 1.2 1.2 1.3 2.2 2.1 1.5 1.3 2.2 1.7 2.3 2.8 3.9 1.3 1.9 2.8 0.9 7.5 14.9 19.8 12.0 9.8 17.5 18.1 14.2 14.4 10.0 12.8 25.5 27.5 32.1 26.7 33.6 22.1 22.7 14.4 9.6 9.1 62.2 17.3 14.0 27.3 11.5 11.6 14.7 83.4 11.5 29.5 19.9 11.7 10.3 107.7 28.7 34.4 22.3 18.0 23.6 37.7 10.0 12.0 19.0 10.7 36.4 20.8 27.7 13.6 10.3 12.5 28.6 37.2 16.0 14.2 18.2 19.7 173.0 21.1 22.0 17.8 37.5 15.1 22.4 15.5 45.8 67.1 15.7 21.8 17.7 24.5 21.2 14.8 7.3 27.2 84.5 6.6 30.0 21.9 81.7 38.0 18.7 21.9 15.2 21.4 30.8 15.8 21.3 TMPPE FLJ45032 ENSG00000188167 "Transmembrane protein with metallophosphoesterase domain" Q6ZT21 3 33090421-33097146 "Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 5.5" "Cell type enhanced" "Detected in some" "Rod photoreceptor cells: 2.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "intermediate monocyte: 2.4" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in many" 6 "BEWO: 27.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027019 Approved Approved Nucleoplasm,Mitochondria Yes No "Cluster 7: Monocytes - Unknown function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 28: BEWO - Transcription regulation" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Mitochondria" "HPA027019: AB_1848942" "unprognostic (1.14e-2)" "unprognostic (1.48e-1)" "unprognostic (1.00e-1)" "unprognostic (1.37e-1)" "unprognostic (5.03e-2)" "unprognostic (2.96e-2)" "unprognostic (6.34e-3)" "unprognostic (8.14e-2)" "unprognostic (1.96e-1)" "unprognostic (1.71e-1)" "unprognostic (1.25e-3)" "unprognostic (9.58e-2)" "unprognostic (1.60e-7)" "unprognostic (1.61e-1)" "unprognostic (5.40e-2)" "unprognostic (2.13e-1)" "unprognostic (4.33e-2)" 0.6 0.5 0.8 1.4 0.7 5.5 0.6 0.7 1.2 0.6 4.3 1.0 1.2 0.5 0.6 0.6 0.9 0.6 0.4 1.5 0.5 1.0 0.6 1.1 1.1 1.4 1.4 0.6 0.7 1.9 0.3 1.2 1.6 0.5 1.2 2.8 0.7 0.6 0.2 1.1 1.1 0.8 0.2 1.5 1.3 0.3 1.7 0.5 1.0 0.3 1.3 0.8 0.4 0.2 1.4 1.9 1.0 1.7 1.2 1.0 27.2 0.6 1.0 1.6 0.9 2.7 3.8 0.8 1.2 1.7 0.9 1.4 1.7 1.5 2.6 4.2 0.6 3.4 1.9 2.1 0.9 3.0 4.7 1.1 1.2 2.0 1.4 0.8 1.9 1.7 2.6 2.9 1.2 1.3 1.2 1.3 1.0 0.4 1.1 1.5 0.6 1.9 1.5 1.9 0.2 0.6 0.9 2.6 0.6 1.3 1.4 4.2 2.7 2.4 3.0 1.3 2.6 2.3 1.6 0.4 3.0 2.2 1.7 0.0 1.1 0.3 0.1 2.4 0.6 0.3 0.2 0.0 1.0 0.1 0.0 0.0 1.9 0.0 1.1 0.2 0.2 0.4 0.8 0.7 0.7 1.2 1.5 0.5 1.4 1.4 1.6 0.2 1.7 0.2 0.3 0.0 1.3 0.0 0.8 0.8 0.1 0.0 0.0 1.2 0.4 0.4 0.4 0.0 0.2 0.0 0.0 1.1 1.9 1.4 0.0 0.4 0.0 0.8 0.6 0.4 0.0 0.4 0.0 0.8 1.7 0.3 0.0 1.1 0.0 0.4 0.4 0.6 0.9 1.7 0.0 0.2 2.0 1.3 1.2 0.0 0.0 1.1 0.0 0.0 0.5 0.2 0.0 0.0 0.0 0.5 1.4 0.4 1.0 0.2 1.4 0.3 0.4 2.2 0.0 0.2 0.7 0.0 0.0 1.5 0.9 0.4 0.6 0.5 0.6 0.2 TMX3 "FLJ20793, KIAA1830, PDIA13, TXNDC10" ENSG00000166479 "Thioredoxin related transmembrane protein 3" Q96JJ7 18 68673688-68715108 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Isomerase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA014157 Uncertain "Intracellular and membrane" NA NA 36000 "Cluster 27: Non-specific - Gene expression" "Cluster 16: Immune cells - Immune response" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "HPA014157: AB_1858469" "unprognostic (2.11e-1)" "unprognostic (5.15e-2)" "unprognostic (2.14e-2)" "unprognostic (9.47e-2)" "unprognostic (6.82e-2)" "unprognostic (7.20e-2)" "unprognostic (4.96e-3)" "unprognostic (1.54e-1)" "unprognostic (3.21e-3)" "unprognostic (5.20e-2)" "unprognostic (9.83e-3)" "unprognostic (2.73e-1)" "prognostic unfavorable (2.87e-4)" "unprognostic (2.69e-2)" "unprognostic (1.53e-2)" "unprognostic (1.38e-2)" "unprognostic (1.21e-1)" 22.7 16.2 11.7 24.1 13.0 14.1 19.2 14.2 15.4 15.0 9.9 12.7 18.2 16.6 20.4 14.1 13.8 16.5 20.8 13.5 13.2 14.6 16.2 19.5 27.9 11.1 11.2 13.0 11.9 15.9 9.6 19.8 12.1 17.7 16.3 26.0 10.6 13.0 11.0 16.7 18.8 21.0 11.4 22.6 14.0 11.4 12.1 23.3 17.7 21.0 22.7 20.1 11.2 11.5 11.1 17.4 32.9 25.9 66.6 70.7 24.5 85.7 91.0 61.0 67.7 8.4 31.9 31.4 16.6 125.4 25.9 40.8 21.9 42.9 92.8 30.3 19.6 28.8 27.4 14.7 70.6 62.0 45.7 56.5 27.1 66.2 59.2 61.8 78.4 27.0 18.9 42.5 73.1 6.9 33.3 19.6 13.9 9.1 28.2 30.7 65.5 38.5 51.7 24.2 31.5 24.5 42.0 26.7 31.8 32.4 17.6 52.1 76.4 108.4 30.0 24.7 63.6 28.4 30.4 29.4 65.5 50.1 81.3 2.2 2.9 2.4 3.8 4.7 5.5 3.1 3.9 3.6 4.7 2.1 4.3 4.4 0.7 4.9 3.3 6.4 4.4 2.7 11.7 13.0 14.2 15.4 13.5 13.2 11.1 11.2 12.1 11.4 12.1 11.5 31.4 28.9 27.8 36.2 25.0 20.3 17.2 17.6 12.0 29.1 21.0 15.6 25.1 10.0 18.8 16.5 18.8 15.0 44.3 10.6 1.9 15.2 8.9 18.7 38.5 27.3 18.0 17.0 77.9 10.2 20.8 34.5 13.3 25.6 20.3 24.2 34.2 26.6 18.6 26.9 45.6 13.8 14.2 23.3 26.8 3.3 24.2 23.9 24.9 32.8 18.2 20.5 20.6 49.8 53.1 15.4 15.4 16.6 29.8 19.4 17.5 8.0 28.8 32.5 39.5 23.6 32.0 23.8 28.3 21.7 24.3 12.4 23.3 22.9 9.4 16.6 TNIK KIAA0551 ENSG00000154310 "TRAF2 and NCK interacting kinase" Q9UKE5 3 171058414-171460408 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Neurogenesis, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 33.7" "Cell type enhanced" "Detected in many" "Astrocytes: 1074.4;Excitatory neurons: 248.4;Inhibitory neurons: 360.8;Oligodendrocyte precursor cells: 374.5;Oligodendrocytes: 205.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HEL: 65.2;HMC-1: 71.3;WM-115: 52.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012128, HPA012297" Approved Supported Nucleoplasm,Cytosol NA NA 160000 "Cluster 52: Eosinophils - Transcription" "Cluster 10: Brain - Neuronal signaling" "Cluster 3: HMC-1 - Innate immune response" "Cluster 64: Astrocytes - Nervous system maintenance" Nucleoplasm Cytosol "HPA012128: AB_1858226, HPA012297: AB_1858225" "unprognostic (2.29e-1)" "unprognostic (1.12e-2)" "unprognostic (1.32e-1)" "unprognostic (5.90e-2)" "unprognostic (5.25e-2)" "unprognostic (9.23e-2)" "unprognostic (4.91e-2)" "unprognostic (2.41e-3)" "unprognostic (1.91e-1)" "unprognostic (7.81e-2)" "unprognostic (5.91e-2)" "unprognostic (1.96e-2)" "unprognostic (3.34e-3)" "unprognostic (2.41e-1)" "unprognostic (1.64e-1)" "unprognostic (2.13e-2)" "unprognostic (3.97e-2)" 1.4 4.4 25.7 6.2 33.7 4.4 2.1 4.1 17.5 1.3 0.0 8.2 21.0 3.4 0.9 4.1 2.8 5.1 9.4 20.8 15.7 3.8 3.1 8.9 6.7 25.5 18.7 1.5 3.7 0.5 8.4 1.9 6.3 3.5 6.7 19.4 1.9 4.6 23.2 1.0 21.3 4.3 19.0 4.5 7.0 7.7 20.1 7.0 6.3 23.6 5.3 4.8 2.1 10.7 0.9 1.2 43.4 4.7 0.8 0.1 10.4 9.3 2.5 7.3 4.8 41.5 16.9 0.0 3.4 9.0 6.9 14.1 6.3 2.6 7.3 0.3 9.8 65.2 3.7 0.0 19.0 13.0 71.3 6.1 5.9 4.3 0.9 15.7 43.6 10.5 23.3 0.1 1.1 1.1 4.1 13.5 18.2 30.6 17.9 0.0 11.8 16.6 12.0 0.1 2.1 2.3 5.8 0.4 9.6 4.1 20.4 2.9 0.5 0.0 7.9 20.5 7.1 0.1 0.0 0.1 1.8 13.8 52.1 4.6 0.1 10.5 3.5 0.0 4.4 0.0 4.2 3.2 0.0 0.2 5.8 3.1 0.1 2.4 0.1 0.0 5.3 1.0 25.7 33.7 4.1 17.5 20.8 15.7 25.5 18.7 6.3 19.0 20.1 10.7 0.7 6.4 50.4 1074.4 4.9 2.5 1.6 1.3 9.1 19.2 8.4 6.5 28.6 21.5 7.1 9.2 14.6 6.3 32.5 19.6 5.9 12.1 48.6 1.1 2.5 1.6 13.2 13.5 248.4 7.7 1.3 9.1 21.4 0.3 83.5 0.4 2.5 8.1 2.9 0.0 360.8 10.3 0.0 6.5 1.9 38.0 2.5 10.4 1.8 57.1 1.6 65.0 51.5 374.5 205.5 7.1 21.6 6.4 11.7 0.7 56.2 17.3 1.8 28.7 0.0 12.4 6.2 3.1 1.0 10.3 1.6 2.5 47.4 9.9 16.6 3.2 TNKS "ARTD5, PARP-5a, PARP5A, pART5, TIN1, TINF1, TNKS1" ENSG00000173273 Tankyrase O95271 8 9555912-9782346 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transporters" "Cell cycle, Cell division, Mitosis, mRNA transport, Protein transport, Translocation, Transport, Wnt signaling pathway" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 149.9;Excitatory neurons: 203.2;Inhibitory neurons: 230.6;Oligodendrocyte precursor cells: 313.1;Oligodendrocytes: 285.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA025690 Approved Approved "Nucleoplasm,Nuclear membrane,Nuclear bodies" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 21: Non-specific - Transcription" "Cluster 12: NES - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "Nuclear membrane, Nuclear bodies" "HPA025690: AB_10602249" "unprognostic (2.07e-1)" "unprognostic (1.72e-2)" "unprognostic (5.45e-3)" "unprognostic (8.22e-2)" "unprognostic (2.42e-1)" "unprognostic (1.27e-2)" "unprognostic (4.75e-2)" "unprognostic (1.13e-1)" "unprognostic (9.06e-2)" "unprognostic (8.01e-2)" "unprognostic (6.21e-2)" "unprognostic (9.10e-2)" "unprognostic (4.14e-2)" "unprognostic (1.12e-1)" "unprognostic (5.43e-1)" "unprognostic (7.76e-2)" "unprognostic (5.36e-2)" 7.3 9.3 14.2 6.5 20.5 12.2 9.9 18.5 15.8 12.1 6.9 7.5 6.0 10.5 17.5 5.9 8.2 6.2 7.0 13.4 16.8 6.1 7.5 6.6 8.5 21.5 18.5 13.1 7.5 12.5 12.6 7.9 22.2 7.8 6.8 21.0 7.1 7.7 18.4 11.4 7.8 7.1 14.7 6.5 7.2 20.3 18.3 10.5 9.7 11.8 8.6 7.9 6.9 32.2 8.8 11.5 28.8 17.4 17.8 23.7 10.7 13.4 15.1 10.7 12.0 6.9 6.9 18.9 5.4 13.2 14.3 9.2 16.5 12.5 15.4 4.9 8.6 13.3 10.7 15.6 16.0 6.9 7.9 16.9 14.8 11.1 21.6 17.3 14.6 14.5 12.7 19.6 19.9 5.8 17.5 10.4 18.9 9.7 6.7 13.9 17.8 5.5 12.8 17.8 29.1 21.4 10.5 9.9 19.3 17.3 6.6 10.2 19.7 17.4 10.6 11.9 10.0 6.7 11.8 13.3 18.7 9.5 17.1 2.4 1.1 0.9 2.0 1.1 1.0 1.9 1.6 1.9 1.4 3.2 1.8 2.2 3.5 1.5 1.4 1.8 0.8 0.7 14.2 20.5 18.5 15.8 13.4 16.8 21.5 18.5 22.2 14.7 18.3 32.2 19.7 16.0 11.7 130.9 23.1 11.5 12.8 11.4 12.0 34.1 15.8 13.6 17.0 15.7 12.0 9.2 14.6 11.2 14.9 9.2 1.9 12.4 149.9 19.9 30.6 15.5 13.8 14.5 203.2 8.5 10.9 20.3 19.9 20.9 10.1 33.7 18.9 18.0 7.1 42.1 230.6 10.8 16.2 9.4 8.5 76.3 16.8 10.3 12.4 92.8 8.4 15.1 5.2 313.1 285.7 13.4 12.8 18.0 20.7 12.8 17.2 6.9 28.1 37.0 0.0 28.7 16.6 37.7 15.4 12.9 15.5 12.3 18.1 39.5 12.2 12.8 TNKS2 "ARTD6, PARP-5b, PARP-5c, PARP5B, PARP5C, pART6, TANK2, TNKL" ENSG00000107854 "Tankyrase 2" Q9H2K2 10 91798426-91865475 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Wnt signaling pathway" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036606 Approved Microtubules NA NA "Cluster 24: B-cells - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 30: Epithelial cell lines - Translation" "Cluster 59: Non-specific - Transcription" Microtubules "HPA036606: AB_10673470" "unprognostic (1.12e-1)" "unprognostic (2.66e-1)" "unprognostic (4.16e-1)" "unprognostic (1.61e-2)" "unprognostic (3.07e-2)" "unprognostic (1.51e-2)" "unprognostic (2.14e-1)" "unprognostic (1.41e-1)" "unprognostic (2.93e-1)" "unprognostic (2.59e-2)" "unprognostic (1.50e-1)" "unprognostic (2.26e-2)" "unprognostic (1.00e-1)" "unprognostic (2.35e-1)" "unprognostic (1.69e-1)" "unprognostic (7.97e-2)" "unprognostic (2.53e-1)" 18.4 19.3 14.7 21.2 16.1 38.5 22.2 18.0 17.0 21.1 25.0 14.8 14.9 22.5 19.8 22.8 17.8 20.8 11.1 14.3 14.9 17.4 21.2 19.7 28.1 14.6 15.1 30.3 22.0 21.8 14.4 31.2 15.8 19.6 17.1 31.2 18.5 16.6 55.6 27.3 15.3 20.7 16.0 30.0 19.8 11.8 17.4 37.7 29.6 40.5 29.4 24.1 17.1 19.7 29.1 24.3 48.9 41.7 33.8 30.6 54.5 30.6 55.5 36.5 44.5 21.7 23.2 27.2 14.3 40.0 24.6 30.6 31.0 23.6 51.3 27.7 29.9 22.6 22.9 24.3 32.9 44.0 32.3 31.4 30.6 37.0 65.3 54.8 34.8 24.1 16.9 29.4 38.5 15.6 38.1 29.9 24.6 13.2 16.1 35.2 30.5 20.9 25.0 30.9 12.8 22.9 30.8 13.4 38.7 39.2 32.5 30.3 37.8 19.6 16.5 26.1 29.5 36.7 32.1 34.8 25.9 32.4 17.9 0.2 0.7 1.2 0.9 0.6 0.8 1.0 0.9 0.8 1.0 1.0 0.7 0.6 0.7 1.0 0.6 1.5 0.5 0.4 14.7 16.1 18.0 17.0 14.3 14.9 14.6 15.1 15.8 16.0 17.4 19.7 39.1 41.7 22.3 63.3 51.6 74.6 32.5 23.8 56.9 41.7 38.8 24.0 23.2 8.6 31.0 44.1 47.9 45.2 48.7 19.2 7.9 16.0 4.7 41.1 29.3 37.1 33.0 27.5 77.5 24.5 55.1 30.9 50.4 52.1 2.5 34.8 35.7 35.9 26.1 42.1 78.5 19.3 26.4 55.3 49.4 8.1 31.1 48.4 33.8 67.5 46.5 24.9 37.0 66.9 68.0 29.0 12.3 35.3 45.7 44.7 16.1 16.6 47.4 34.8 46.0 40.5 28.0 19.1 21.7 75.9 109.1 101.0 49.1 30.5 14.9 61.7 TOPORS "LUN, RP31, TP53BPL" ENSG00000197579 "TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase" Q9NS56 9 32540544-32552586 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, Ubl conjugation pathway" Transferase "Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 169.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 67.6" "Lineage enriched" "Detected in all" 4 "granulocytes: 67.6" "Cell line enhanced" "Detected in all" "HEL: 90.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA060640, HPA065661" Supported Supported Nucleoplasm NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 34: Non-specific - Transcription" "Cluster 36: HEL - Hemostasis" "Cluster 29: Early spermatids - Spermatogenesis" Nucleoplasm "HPA060640: AB_2684334, HPA065661: AB_2685527" "unprognostic (1.75e-1)" "unprognostic (1.73e-1)" "unprognostic (1.20e-2)" "unprognostic (1.14e-2)" "unprognostic (1.29e-1)" "unprognostic (1.01e-1)" "unprognostic (1.45e-1)" "unprognostic (1.37e-2)" "unprognostic (9.94e-2)" "prognostic favorable (7.07e-4)" "unprognostic (2.70e-1)" "unprognostic (3.61e-1)" "prognostic favorable (6.64e-6)" "unprognostic (1.22e-1)" "unprognostic (5.95e-2)" "unprognostic (3.13e-1)" "unprognostic (2.92e-1)" 9.8 9.8 5.4 8.4 6.3 25.2 12.4 10.5 8.5 10.3 7.3 9.2 8.3 11.4 10.0 9.9 7.6 8.7 6.8 5.4 6.6 13.2 16.2 9.3 9.3 6.1 6.1 15.3 8.6 14.0 6.9 10.0 6.2 11.2 9.3 11.5 7.6 9.3 7.2 9.6 8.8 11.2 5.9 10.5 8.9 14.8 6.6 14.5 14.1 10.4 10.1 10.3 7.2 8.3 16.6 15.1 20.4 17.9 24.4 21.8 12.9 20.7 19.5 16.9 19.5 9.5 8.3 26.8 11.7 20.8 14.8 10.9 24.2 23.5 23.6 22.5 13.3 90.8 25.2 11.9 15.1 26.1 24.0 17.9 25.8 24.4 17.1 20.9 20.8 20.1 16.1 13.6 27.9 8.9 23.5 47.6 27.2 12.3 15.2 23.9 18.1 12.2 22.5 17.2 10.1 16.1 20.7 11.2 13.8 22.9 11.3 14.7 22.0 18.4 18.6 9.6 15.5 9.5 16.2 28.5 17.0 14.8 8.4 38.8 10.0 21.3 9.6 9.8 10.3 9.4 10.4 11.4 10.2 10.8 13.9 13.8 67.6 15.0 13.6 8.2 13.5 7.3 5.4 6.3 10.5 8.5 5.4 6.6 6.1 6.1 6.2 5.9 6.6 8.3 69.2 54.5 32.0 10.7 49.1 47.2 45.3 33.7 61.5 46.8 32.7 28.6 18.4 25.8 37.0 25.8 37.5 31.9 63.4 26.3 19.6 25.1 169.9 36.2 38.1 48.8 45.9 66.5 14.5 18.4 16.9 42.0 25.0 45.5 41.8 43.6 26.4 24.3 17.7 55.5 15.5 22.9 44.7 19.1 35.3 21.8 33.2 31.8 19.6 7.5 30.4 43.5 36.0 13.0 22.4 21.1 24.3 32.7 39.5 39.0 24.3 22.7 22.3 42.0 19.7 54.0 48.2 54.4 53.7 39.0 47.6 50.8 55.4 43.1 24.0 49.8 TP53RK "BUD32, C20orf64, dJ101A2.2, Nori-2p, prpk, TPRKB" ENSG00000172315 "TP53 regulating kinase" Q96S44 20 46684365-46689444 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "tRNA processing" "Hydrolase, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 214.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HMC-1: 212.4;SK-MEL-30: 90.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004688, HPA015837" Approved NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 3: HMC-1 - Innate immune response" "Cluster 66: Spermatocytes - Spermatogenesis" "CAB004688: AB_426116, HPA015837: AB_1855776" "unprognostic (9.45e-2)" "unprognostic (3.73e-1)" "unprognostic (9.76e-2)" "prognostic unfavorable (6.70e-5)" "unprognostic (4.41e-2)" "unprognostic (2.63e-1)" "prognostic unfavorable (6.27e-5)" "unprognostic (9.16e-3)" "unprognostic (6.11e-2)" "unprognostic (2.10e-1)" "unprognostic (2.36e-1)" "unprognostic (5.72e-2)" "unprognostic (1.25e-2)" "unprognostic (3.37e-2)" "unprognostic (1.75e-1)" "unprognostic (1.59e-1)" "unprognostic (1.74e-2)" 6.5 7.7 6.0 7.3 5.3 6.3 8.9 4.7 6.1 6.9 2.6 6.5 4.8 7.0 4.6 8.8 6.3 5.7 5.1 5.0 6.1 6.8 7.0 5.7 11.2 5.1 5.3 6.2 5.4 7.4 6.2 6.0 5.0 7.9 6.0 6.4 7.1 6.1 6.7 9.6 5.9 6.8 4.8 7.0 7.0 12.1 6.9 13.2 8.0 5.3 11.9 10.6 6.8 6.5 12.7 8.7 17.9 15.9 18.5 15.1 16.6 17.7 16.3 22.7 16.4 24.7 8.0 32.2 26.1 14.6 20.3 19.6 23.1 20.3 19.6 7.9 12.0 31.0 8.4 22.4 24.3 20.2 212.4 20.3 24.2 15.8 15.4 10.6 15.3 12.7 21.5 13.1 19.6 19.1 31.0 35.5 14.6 18.1 29.8 17.9 16.2 19.1 15.2 14.1 21.6 11.5 21.3 42.1 90.7 9.3 15.4 21.8 15.7 26.3 15.5 17.5 19.8 14.5 19.6 24.7 15.2 15.2 12.6 36.6 16.1 28.4 16.9 15.8 19.5 19.9 18.2 19.4 16.7 19.3 19.9 17.1 2.7 22.5 14.6 25.4 25.5 17.4 6.0 5.3 4.7 6.1 5.0 6.1 5.1 5.3 5.0 4.8 6.9 6.5 12.6 9.6 13.1 5.2 14.3 50.7 54.8 45.9 39.9 9.4 22.8 21.2 7.0 18.6 27.7 9.2 12.5 42.6 23.9 10.4 27.4 28.9 214.7 13.3 25.6 17.5 13.1 16.2 5.0 23.8 73.6 29.1 23.4 14.2 22.9 14.6 11.0 12.2 25.8 15.2 4.7 16.5 32.6 14.4 28.5 49.9 22.1 13.1 37.4 4.7 17.9 8.1 21.6 6.0 6.0 34.7 4.9 16.1 8.4 62.6 15.5 31.1 18.0 10.4 6.6 8.8 26.1 87.6 15.6 35.2 61.8 88.7 19.4 26.8 13.1 59.9 TPMT ENSG00000137364 "Thiopurine S-methyltransferase" P51580 6 18128311-18155077 "Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "kidney: 76.4;liver: 68.8;thyroid gland: 76.9" "Cell type enhanced" "Detected in many" "Distal enterocytes: 144.6;Proximal tubular cells: 307.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019851, HPA062364" Enhanced NA NA 39000 "Cluster 7: Monocytes - Unknown function" "Cluster 7: Kidney - Transmembrane transport" "Cluster 17: WM-115 - Nervous system development" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA019851: AB_1858213, HPA062364: " "unprognostic (6.24e-2)" "unprognostic (3.16e-2)" "unprognostic (5.46e-3)" "prognostic unfavorable (8.45e-5)" "unprognostic (4.98e-2)" "unprognostic (2.25e-1)" "unprognostic (8.16e-2)" "unprognostic (4.36e-3)" "unprognostic (9.62e-2)" "prognostic favorable (1.41e-4)" "unprognostic (4.49e-2)" "unprognostic (3.40e-2)" "prognostic favorable (1.10e-4)" "unprognostic (7.56e-2)" "unprognostic (1.31e-1)" "unprognostic (1.07e-1)" "unprognostic (8.39e-3)" 5.8 16.4 9.2 12.9 12.2 10.0 10.0 10.5 12.2 7.7 9.6 34.5 34.5 6.9 17.5 10.3 7.0 10.4 12.2 10.4 9.7 76.4 68.8 9.3 10.0 9.8 9.7 4.5 11.6 18.0 7.5 5.6 9.9 10.8 35.1 13.1 12.1 6.6 13.2 10.3 28.9 10.5 9.3 11.0 12.2 6.7 9.9 9.2 76.9 11.7 10.1 15.9 7.4 9.8 24.5 7.3 7.9 19.9 12.9 24.9 19.5 27.7 30.8 23.3 36.2 17.1 5.9 3.1 20.3 37.0 18.0 12.0 11.3 20.0 38.6 16.2 16.2 20.0 12.0 25.2 14.1 9.3 17.4 14.5 21.2 26.0 16.5 15.1 32.9 13.5 40.6 5.6 17.2 11.1 9.6 12.7 13.2 33.9 20.7 11.9 19.6 13.8 27.2 24.8 13.0 10.0 18.3 31.9 36.9 19.9 22.9 9.0 14.0 53.1 10.3 28.0 40.0 8.1 38.9 8.0 19.0 12.3 54.5 8.7 22.1 7.2 11.6 46.7 14.9 2.7 9.2 11.1 32.3 2.6 8.1 11.2 2.2 10.4 40.7 6.5 16.2 17.2 9.2 12.2 10.5 12.2 10.4 9.7 9.8 9.7 9.9 9.3 9.9 9.8 13.9 16.0 15.5 4.6 12.6 42.7 41.3 23.0 13.6 15.3 20.9 15.0 22.9 25.8 15.8 35.0 22.9 20.7 20.5 144.6 115.4 52.7 1.2 38.4 15.3 14.3 24.0 18.1 18.7 37.4 25.3 11.3 14.8 39.4 22.9 4.3 17.5 86.5 44.9 6.7 13.2 34.8 22.4 48.5 60.9 2.8 4.1 41.1 24.9 9.4 32.6 33.5 29.9 11.1 10.2 76.8 106.6 10.1 9.7 38.8 80.8 307.6 12.2 19.5 0.0 9.3 13.9 0.7 7.7 19.5 34.5 17.5 21.1 9.5 50.7 78.9 TPP1 "CLN2, LPIC, SCAR7, TPP-1" ENSG00000166340 "Tripeptidyl peptidase 1" O14773 11 6612768-6619448 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Disease variant, Epilepsy, Neurodegeneration, Neuronal ceroid lipofuscinosis, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hofbauer cells: 261.6;Kupffer cells: 376.5;Macrophages: 219.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037709, HPA044868" Enhanced "Intracellular and membrane" NA NA 9500000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 3: HMC-1 - Innate immune response" "Cluster 4: Macrophages - Innate immune response" "HPA037709: AB_10672913, HPA044868: AB_2679122" "unprognostic (8.27e-3)" "unprognostic (5.85e-2)" "unprognostic (7.12e-3)" "unprognostic (3.34e-3)" "unprognostic (1.56e-2)" "prognostic unfavorable (4.31e-4)" "prognostic unfavorable (1.11e-4)" "unprognostic (6.32e-2)" "unprognostic (3.01e-1)" "unprognostic (2.39e-2)" "unprognostic (1.31e-1)" "unprognostic (6.54e-2)" "unprognostic (6.23e-2)" "prognostic unfavorable (4.46e-4)" "unprognostic (3.87e-2)" "unprognostic (2.59e-1)" "unprognostic (1.12e-2)" 74.7 145.9 71.0 74.6 81.0 111.7 44.3 80.3 81.4 53.8 120.1 59.1 59.9 74.0 43.1 39.5 47.1 65.1 56.3 70.6 78.4 71.6 92.7 81.5 77.7 85.2 82.6 49.7 36.2 54.2 63.6 94.2 81.0 38.9 59.7 48.5 42.5 57.5 31.4 39.5 73.3 92.0 74.7 135.0 48.4 20.0 83.3 47.4 45.7 39.0 60.9 68.4 42.8 90.4 26.1 48.1 25.9 50.5 309.9 160.1 21.8 50.9 220.7 36.9 62.0 20.1 122.5 37.4 32.6 136.6 220.2 85.8 48.3 68.7 57.9 37.3 27.6 32.2 23.8 54.9 210.9 45.8 182.6 231.8 104.5 45.9 102.6 240.4 158.8 32.9 59.8 124.6 110.4 30.2 16.6 52.4 18.0 61.5 57.1 36.1 21.6 77.0 62.8 38.2 4.5 20.4 52.6 44.6 91.0 76.5 30.8 79.7 188.0 119.7 33.1 101.1 19.8 92.3 95.3 14.0 139.8 101.7 64.5 67.0 167.1 38.2 39.9 171.2 30.0 35.1 31.4 41.0 185.9 37.0 20.1 27.2 27.5 29.1 125.1 93.1 60.3 138.8 71.0 81.0 80.3 81.4 70.6 78.4 85.2 82.6 81.0 74.7 83.3 90.4 32.0 25.6 37.3 31.6 53.0 23.7 28.4 29.8 13.1 24.8 21.1 23.9 41.8 50.1 26.8 16.5 12.5 35.4 71.0 55.2 5.9 42.2 11.8 13.3 30.2 40.7 16.7 37.5 12.5 13.4 45.3 40.3 16.3 24.8 62.2 25.6 75.7 81.0 261.6 15.2 12.4 31.3 26.4 376.5 126.5 11.2 27.1 219.8 90.7 15.9 156.0 37.9 49.4 8.0 21.9 17.4 44.1 26.4 26.4 23.5 99.7 51.6 14.5 23.8 6.6 19.0 20.3 0.8 1.1 27.6 20.0 88.0 42.2 24.6 32.5 26.5 TPSAB1 "TPS1, TPS2, TPSB1" ENSG00000172236 "Tryptase alpha/beta 1" Q15661 16 1240379-1242554 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in some" 13 "granulocytes: 5873.9" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 893 "basophil: 89.3" "Lineage enriched" "Detected in single" 893 "granulocytes: 89.3" "Cell line enriched" "Detected in some" 166 "HMC-1: 3813.2" "CAB016369, CAB022175, HPA049153, HPA049554" Supported "Secreted to blood" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 3: HMC-1 - Innate immune response" "Cluster 60: Granulocytes - Receptor signaling" "CAB016369: AB_628406, CAB022175: , HPA049153: AB_2680656, HPA049554: AB_2680815" "unprognostic (2.06e-2)" "unprognostic (5.14e-2)" "unprognostic (2.02e-3)" "unprognostic (1.64e-2)" "unprognostic (9.31e-3)" "prognostic favorable (9.62e-6)" "unprognostic (1.02e-1)" "unprognostic (4.08e-2)" "unprognostic (1.80e-1)" "unprognostic (1.43e-1)" "unprognostic (2.24e-1)" "unprognostic (2.83e-2)" "unprognostic (4.13e-2)" "unprognostic (2.23e-1)" "unprognostic (2.81e-2)" "unprognostic (1.16e-1)" "unprognostic (1.36e-2)" 96.6 2.9 0.3 23.6 0.5 2.4 47.2 0.3 0.9 53.7 0.9 83.0 71.6 73.3 6.0 64.3 26.6 129.7 14.7 0.4 0.4 13.9 12.2 128.5 21.3 0.4 0.3 3.2 18.9 2.3 3.5 1.2 0.6 65.9 34.6 0.0 60.2 22.5 10.1 122.7 148.7 17.9 0.4 5.9 104.0 8.9 0.4 14.2 4.7 13.0 13.2 113.5 52.6 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 2.7 0.0 0.0 0.0 0.0 0.0 19.3 0.0 0.0 0.0 1.3 3813.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.7 0.0 0.3 2.1 6.1 0.5 0.4 0.0 0.4 0.0 0.5 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.5 0.1 1.1 0.0 0.0 2.8 22.9 2.0 89.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.3 0.5 0.3 0.9 0.4 0.4 0.4 0.3 0.6 0.4 0.4 0.3 0.0 25.6 135.5 0.0 2.9 18.6 5.1 0.0 1.2 0.0 0.9 0.1 0.3 0.0 8.1 0.0 0.0 0.0 0.2 0.9 0.0 1.2 0.3 0.0 0.0 4.1 0.0 3.8 0.0 0.0 0.2 7.6 0.5 0.0 5873.9 0.0 0.0 0.3 5.2 0.0 0.0 0.0 0.0 0.3 25.6 0.2 0.0 7.7 19.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 11.7 4.0 0.4 0.1 5.1 0.0 0.0 0.3 3.2 0.0 0.1 0.1 9.9 0.3 440.9 0.0 0.5 5.6 TPSB2 ENSG00000197253 "Tryptase beta 2" P20231 16 1227272-1230184 "Enzymes, Metabolic proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in some" 25 "granulocytes: 8966.1" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 50 "basophil: 5.0" "Lineage enriched" "Detected in single" 50 "granulocytes: 5.0" "Cell line enriched" "Detected in some" 7 "HMC-1: 297.5" "HPA049153, HPA049554" Supported "Secreted to blood" NA NA 16000000 "Cluster 10: Basophils - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 3: HMC-1 - Innate immune response" "Cluster 60: Granulocytes - Receptor signaling" "HPA049153: AB_2680656, HPA049554: AB_2680815" "unprognostic (9.05e-2)" "unprognostic (8.46e-3)" "unprognostic (2.42e-3)" "unprognostic (2.27e-2)" "unprognostic (4.97e-3)" "unprognostic (1.02e-3)" "unprognostic (1.11e-1)" "unprognostic (8.55e-2)" "unprognostic (2.48e-1)" "unprognostic (2.24e-1)" "unprognostic (1.95e-1)" "unprognostic (8.30e-3)" "unprognostic (1.91e-2)" "unprognostic (5.76e-2)" "unprognostic (2.41e-2)" "unprognostic (4.65e-2)" "unprognostic (3.17e-2)" 95.1 2.5 0.3 20.2 0.6 4.3 47.8 0.3 0.9 53.2 1.0 77.8 35.5 71.8 9.8 64.6 30.4 103.9 15.0 0.5 0.5 15.5 12.2 127.8 26.2 0.5 0.4 3.5 18.9 1.5 3.9 1.3 0.5 67.0 19.8 0.0 64.5 13.3 10.0 122.5 146.1 22.0 0.5 5.2 102.1 9.9 0.5 4.9 4.7 10.4 9.9 118.6 53.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.0 41.2 0.0 0.0 0.2 0.4 297.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.3 4.7 0.3 1.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.4 0.0 0.7 5.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.6 0.3 0.9 0.5 0.5 0.5 0.4 0.5 0.5 0.5 0.3 0.1 38.5 275.3 0.0 2.8 0.0 4.4 0.0 0.0 0.0 1.5 0.0 1.5 0.0 16.7 0.0 0.0 0.1 0.6 0.7 0.0 2.4 0.6 0.0 0.0 3.2 0.0 18.9 0.0 0.0 0.2 6.0 2.0 0.0 8966.1 0.0 0.0 0.0 3.8 0.0 0.1 0.7 0.0 0.0 0.0 1.0 0.0 11.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 25.8 5.4 0.7 0.1 3.6 0.0 0.0 0.4 1.1 0.0 0.7 0.0 0.0 0.1 345.1 0.0 1.0 6.1 TPSD1 ENSG00000095917 "Tryptase delta 1" Q9BZJ3 16 1256059-1259008 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "stomach 1: 21.2" "Cell type enriched" "Detected in some" 19 "granulocytes: 202.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 29 "basophil: 2.9" "Lineage enriched" "Detected in single" 29 "granulocytes: 2.9" "Group enriched" "Detected in some" 49 "HEL: 28.2;HMC-1: 40.4" "CAB002215, CAB032871, HPA040182, HPA049554" Supported "Intracellular and membrane" NA NA "Cluster 10: Basophils - Unknown function" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 60: Granulocytes - Receptor signaling" "CAB002215: AB_563870, CAB032871: AB_2206475, HPA040182: AB_2676875, HPA049554: AB_2680815" "unprognostic (5.99e-2)" "unprognostic (3.00e-1)" "unprognostic (1.38e-1)" "unprognostic (1.04e-2)" "unprognostic (8.97e-3)" "unprognostic (1.15e-4)" "unprognostic (1.70e-1)" "unprognostic (5.45e-2)" "unprognostic (9.00e-2)" "unprognostic (2.88e-1)" "unprognostic (4.30e-1)" "unprognostic (2.94e-2)" "unprognostic (2.50e-3)" "unprognostic (3.74e-2)" "unprognostic (4.14e-1)" "unprognostic (3.89e-1)" "unprognostic (7.46e-3)" 8.0 0.5 1.2 1.9 1.3 1.6 4.5 1.3 2.7 5.1 1.0 7.8 3.8 8.5 1.9 8.1 3.2 13.8 1.1 1.4 1.1 1.2 0.7 17.8 5.4 1.4 1.3 0.3 1.5 0.1 0.4 0.1 1.5 5.5 0.8 0.1 4.8 1.2 1.4 9.5 13.4 5.4 1.1 0.4 21.2 1.3 1.4 1.2 0.3 1.0 2.3 13.3 5.0 1.2 0.0 0.1 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 28.2 0.0 0.0 0.0 0.2 40.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.6 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 1.3 1.3 2.7 1.4 1.1 1.4 1.3 1.5 1.1 1.4 1.2 0.0 3.2 7.7 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 10.5 0.0 0.0 0.0 0.2 0.0 0.0 202.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.1 TRAF7 "DKFZp586I021, MGC7807, RFWD1, RNF119" ENSG00000131653 "TNF receptor associated factor 7" Q6Q0C0 16 2155698-2178129 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Transcription, Transcription regulation, Ubl conjugation pathway" Transferase "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041229 Approved Supported "Vesicles,Plasma membrane" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 7: Non-specific - Mitochondria" Vesicles "Plasma membrane" "HPA041229: AB_10794194" "unprognostic (1.94e-1)" "unprognostic (5.97e-2)" "unprognostic (1.13e-1)" "unprognostic (4.23e-2)" "unprognostic (1.09e-1)" "unprognostic (1.03e-1)" "unprognostic (1.65e-2)" "unprognostic (2.77e-3)" "unprognostic (7.08e-2)" "unprognostic (3.52e-2)" "unprognostic (1.52e-2)" "unprognostic (1.08e-1)" "unprognostic (9.23e-2)" "unprognostic (6.07e-2)" "unprognostic (2.99e-2)" "unprognostic (2.43e-1)" "unprognostic (8.48e-2)" 29.1 29.4 16.5 24.4 15.1 35.0 28.2 18.2 23.0 32.1 17.0 38.0 40.0 31.2 11.6 54.6 30.4 22.2 21.3 17.9 14.6 28.1 51.5 33.2 22.9 17.8 15.3 23.5 37.4 14.6 32.1 20.6 14.8 27.0 17.4 8.5 34.7 16.5 30.4 47.7 35.2 18.8 14.2 34.5 35.6 14.8 17.7 19.1 25.6 9.9 18.6 34.5 34.8 14.3 57.7 72.2 40.3 72.5 40.8 76.5 47.4 43.4 53.9 49.9 44.6 88.2 72.1 36.6 50.2 55.4 31.8 65.9 38.1 76.8 18.8 58.3 48.8 52.4 98.5 68.3 53.8 56.3 72.7 76.2 62.8 48.1 62.6 41.0 97.4 70.6 57.1 47.9 48.2 131.1 58.3 65.2 79.7 78.7 34.8 107.4 66.7 74.2 40.2 30.4 80.9 67.2 36.3 68.5 48.6 20.9 78.1 68.2 74.3 60.2 83.9 56.7 48.2 69.2 55.0 48.4 34.4 35.9 47.8 4.0 9.1 7.3 4.5 12.4 4.3 5.5 4.4 4.7 11.2 3.9 3.1 3.8 6.2 2.9 8.9 5.3 6.5 5.3 16.5 15.1 18.2 23.0 17.9 14.6 17.8 15.3 14.8 14.2 17.7 14.3 18.9 0.0 9.2 12.4 18.2 28.8 21.1 34.2 22.8 15.9 31.6 27.9 4.9 21.5 20.8 14.7 6.2 23.5 17.4 56.4 17.6 39.0 5.0 23.6 34.6 26.5 34.0 33.6 8.9 59.0 36.3 19.0 38.7 27.9 9.5 22.1 26.0 32.3 42.2 37.0 8.2 38.7 34.6 41.8 21.3 13.1 24.8 26.8 10.6 8.4 33.9 12.6 6.2 6.6 4.9 53.0 43.6 22.2 24.0 33.8 80.0 29.2 19.7 10.9 6.6 11.9 18.3 8.5 25.3 50.7 32.5 26.7 16.0 29.0 42.5 38.5 TRHDE "PAP-II, PGPEP2, TRH-DE" ENSG00000072657 "Thyrotropin releasing hormone degrading enzyme" Q9UKU6 12 72087266-72670758 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 7.6;pancreas: 10.3" "Group enriched" "Detected in some" 4 "Excitatory neurons: 216.9;Inhibitory neurons: 292.7" "Cancer enhanced" "Detected in some" "renal cancer: 1.9" "Group enriched" "Detected in many" 5 "basal ganglia: 4.9;cerebellum: 4.4;cerebral cortex: 2.5;hippocampal formation: 7.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ: 30.3;BJ hTERT+: 29.1;EFO-21: 15.3;HBF TERT88: 10.3;hTERT-RPE1: 10.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA 7300000 "Cluster 22: Non-specific - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (3.56e-2)" "unprognostic (4.06e-3)" "unprognostic (6.01e-2)" "unprognostic (1.44e-6)" "unprognostic (1.77e-1)" "unprognostic (6.37e-2)" "unprognostic (7.79e-2)" "unprognostic (6.96e-2)" "unprognostic (3.99e-2)" "unprognostic (1.48e-1)" "unprognostic (5.14e-4)" "unprognostic (2.40e-1)" "prognostic favorable (1.53e-7)" "unprognostic (2.55e-2)" "unprognostic (2.48e-1)" "unprognostic (8.91e-3)" "unprognostic (2.94e-2)" 3.6 0.9 0.1 0.3 4.9 0.4 0.8 4.4 2.5 3.7 0.0 1.1 2.4 1.2 0.6 0.2 1.1 0.8 0.8 7.6 0.0 5.1 0.5 1.4 0.1 0.0 0.9 3.2 10.3 0.0 0.1 0.1 0.0 1.3 0.5 0.8 0.8 2.8 0.2 0.2 2.1 0.4 0.0 2.5 0.3 0.7 0.0 0.1 0.0 0.4 0.3 1.2 2.3 0.0 3.6 0.0 0.6 0.0 1.6 0.0 9.5 30.3 29.1 2.9 1.9 0.0 0.0 0.0 15.3 4.3 3.0 0.4 5.4 0.0 10.3 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 2.4 0.0 0.0 2.3 10.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 8.7 0.0 0.0 0.0 9.5 6.7 2.9 0.1 0.0 0.0 0.0 0.5 0.0 5.7 0.0 0.0 3.2 0.0 0.5 0.0 0.0 0.0 0.0 0.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 4.9 4.4 2.5 7.6 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.2 0.0 0.5 2.9 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.9 1.5 0.0 1.8 0.0 0.1 0.0 7.1 3.9 0.0 35.9 0.1 0.4 0.2 0.0 0.0 216.9 2.6 0.4 4.7 0.0 0.3 0.0 0.1 0.4 1.4 0.2 0.0 292.7 3.5 0.0 0.0 0.0 62.8 29.5 0.7 0.0 2.8 0.0 0.4 0.0 38.2 4.0 2.2 3.9 13.5 0.0 0.2 15.8 9.1 0.7 0.6 0.0 37.4 0.6 0.2 0.7 0.0 0.0 0.1 0.1 0.2 1.6 0.1 TRIM11 "BIA1, RNF92" ENSG00000154370 "Tripartite motif containing 11" Q96F44 1 228393673-228406835 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Antiviral defense, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 154.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028541, HPA043879" Approved Enhanced Nucleoplasm,Cytosol NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 18: Non-specific - Mitochondria" "Cluster 28: BEWO - Transcription regulation" "Cluster 29: Early spermatids - Spermatogenesis" "Nucleoplasm, Cytosol" "HPA028541: AB_10600833, HPA043879: AB_2678711" "unprognostic (1.73e-1)" "unprognostic (9.73e-3)" "unprognostic (5.48e-3)" "unprognostic (7.73e-2)" "unprognostic (3.27e-1)" "unprognostic (2.33e-1)" "prognostic unfavorable (7.42e-5)" "unprognostic (1.08e-1)" "unprognostic (9.74e-2)" "unprognostic (2.04e-1)" "unprognostic (1.40e-1)" "unprognostic (3.15e-1)" "prognostic unfavorable (1.62e-4)" "unprognostic (3.40e-2)" "unprognostic (4.89e-2)" "unprognostic (2.04e-1)" "unprognostic (1.22e-2)" 10.2 12.1 12.7 8.9 16.0 30.7 10.4 23.9 15.2 14.7 10.1 13.6 7.7 11.5 4.5 20.7 12.7 6.1 8.7 14.4 11.6 12.2 10.2 11.8 12.2 11.6 9.9 11.9 11.9 6.7 9.8 5.6 10.8 15.4 7.1 2.0 17.1 7.0 5.0 17.1 14.6 4.6 8.6 24.1 12.9 14.9 13.2 10.1 11.0 3.1 8.7 11.7 15.6 11.0 28.3 26.3 13.8 19.1 10.2 8.4 65.1 18.1 12.1 20.5 16.4 32.2 24.0 21.1 19.7 12.2 13.5 45.1 16.8 17.4 8.6 23.6 40.5 17.5 26.7 17.6 27.6 22.2 25.6 11.3 27.2 21.3 10.6 10.5 10.2 33.9 40.7 26.4 10.7 18.2 27.1 35.1 35.3 23.9 22.9 26.3 12.5 25.8 13.4 34.0 22.9 42.0 15.1 42.2 24.7 5.6 29.9 36.8 11.6 13.0 18.3 30.6 37.9 26.9 19.3 18.9 16.1 17.7 20.9 5.2 4.5 5.6 5.5 5.3 5.9 3.7 6.4 7.1 4.4 3.5 3.6 5.1 6.2 6.2 7.5 3.5 6.4 3.9 12.7 16.0 23.9 15.2 14.4 11.6 11.6 9.9 10.8 8.6 13.2 11.0 7.8 3.2 5.8 1.6 12.1 15.8 16.3 7.4 10.8 12.1 13.3 10.7 3.6 12.8 10.4 1.8 2.1 15.7 21.6 28.1 17.6 14.8 154.2 11.2 10.2 10.1 14.4 12.6 9.8 11.0 15.5 8.5 23.4 17.1 5.7 13.4 8.9 5.7 11.8 5.0 4.7 21.7 4.1 12.6 9.3 16.5 9.6 11.0 5.4 2.8 22.0 10.3 30.9 3.0 3.2 18.3 21.1 7.5 12.8 17.4 17.8 9.9 7.3 1.6 6.6 8.4 9.1 7.3 12.4 15.8 19.5 57.3 18.9 14.9 17.6 30.1 TRIM32 "BBS11, HT2A, LGMD2H, TATIP" ENSG00000119401 "Tripartite motif containing 32" Q13049 9 116687305-116701300 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Bardet-Biedl syndrome, Ciliopathy, Disease variant, Limb-girdle muscular dystrophy, Mental retardation, Obesity" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA050060 Approved Approved "Intermediate filaments" No No "Cluster 35: T-regs - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" "Intermediate filaments" "HPA050060: AB_2681000" "unprognostic (2.47e-2)" "unprognostic (7.06e-3)" "unprognostic (5.50e-2)" "unprognostic (3.63e-1)" "unprognostic (5.08e-2)" "prognostic unfavorable (4.53e-4)" "prognostic unfavorable (4.72e-4)" "unprognostic (2.41e-3)" "unprognostic (2.92e-1)" "unprognostic (5.01e-2)" "unprognostic (1.79e-2)" "unprognostic (5.63e-2)" "unprognostic (6.03e-2)" "unprognostic (7.06e-2)" "unprognostic (2.73e-1)" "unprognostic (6.64e-3)" "unprognostic (9.77e-2)" 6.7 7.2 4.6 5.4 4.5 1.0 6.8 16.4 5.4 10.1 15.2 6.0 5.9 10.6 6.5 7.4 13.1 6.4 7.9 4.7 6.1 5.2 3.8 5.5 8.1 3.6 2.8 10.1 6.2 8.6 3.5 6.1 3.9 6.9 6.2 7.2 5.2 7.3 18.6 4.6 7.2 10.7 2.1 6.2 5.4 5.2 4.5 7.5 6.3 12.5 7.4 7.6 5.7 3.4 10.9 24.5 14.3 15.7 28.3 20.1 10.8 19.9 21.7 22.1 18.4 16.4 11.7 11.3 8.6 30.7 16.5 22.8 17.5 22.4 20.0 9.9 8.5 6.1 15.4 10.2 14.7 4.1 19.1 17.4 19.7 21.0 12.3 24.4 14.6 12.4 8.6 9.3 26.3 13.9 11.0 0.1 13.0 26.2 14.6 12.7 38.2 7.4 9.0 25.1 14.2 7.2 15.7 10.8 11.4 14.3 29.8 4.0 18.2 20.4 16.2 15.3 15.2 15.1 4.3 17.7 17.0 2.7 20.5 0.0 1.7 0.0 10.9 3.3 8.4 7.3 9.5 8.7 2.3 5.1 9.6 9.8 0.3 7.0 3.0 4.3 20.9 6.0 4.6 4.5 16.4 5.4 4.7 6.1 3.6 2.8 3.9 2.1 4.5 3.4 2.5 6.4 0.6 5.5 4.3 4.2 6.3 9.3 5.7 11.7 3.1 3.7 7.6 7.2 7.3 9.2 0.0 6.7 2.1 1.7 1.9 8.5 3.5 7.1 10.7 3.6 4.2 0.4 7.6 8.0 3.6 6.1 3.6 2.3 2.5 4.5 2.9 4.1 7.2 1.7 10.1 4.0 8.2 2.4 4.7 2.1 5.3 2.2 1.8 1.9 0.8 4.0 3.1 6.6 5.1 5.0 2.6 12.0 3.1 2.8 10.6 3.1 10.8 4.8 0.0 6.0 6.6 17.7 13.1 5.6 3.7 7.4 4.7 5.0 5.3 4.8 TRIM33 "FLJ11429, KIAA1113, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA" ENSG00000197323 "Tripartite motif containing 33" Q9UPN9 1 114392790-114511203 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "DNA-binding, Repressor, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 237.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 13.2" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MCF7: 115.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004345 Supported Approved Nucleoplasm,Vesicles NA NA "Cluster 38: Basophils - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 44: Endometrium - Transcription" Vesicles Nucleoplasm "HPA004345: AB_1858287" "unprognostic (8.90e-2)" "unprognostic (5.86e-2)" "prognostic favorable (6.20e-4)" "unprognostic (1.09e-2)" "unprognostic (8.42e-3)" "prognostic favorable (8.93e-4)" "unprognostic (1.34e-2)" "unprognostic (1.83e-1)" "unprognostic (6.75e-2)" "unprognostic (4.58e-2)" "unprognostic (2.14e-1)" "unprognostic (1.08e-1)" "unprognostic (2.27e-2)" "unprognostic (4.84e-2)" "unprognostic (1.99e-1)" "unprognostic (1.40e-1)" "unprognostic (1.68e-1)" 9.3 8.1 10.1 10.7 11.3 25.4 13.5 18.3 16.9 12.5 8.2 9.5 8.8 15.2 29.8 11.7 9.1 10.9 8.9 11.5 9.9 13.5 12.2 10.9 13.3 8.0 9.1 14.4 12.2 15.3 7.3 16.0 8.2 12.6 10.1 18.8 10.7 11.0 8.8 14.8 8.9 11.8 8.1 12.7 11.2 25.3 9.5 17.8 14.2 10.7 12.8 11.5 9.8 11.3 30.9 16.3 30.1 22.6 12.5 13.1 51.0 15.4 16.3 20.9 22.1 18.5 12.8 32.8 15.5 18.1 13.6 17.4 27.6 18.0 28.6 24.9 16.4 31.6 21.7 21.6 13.8 40.3 25.3 12.5 12.9 24.9 25.2 16.0 17.8 27.3 40.1 22.5 20.2 115.4 40.9 17.0 40.7 11.7 16.3 34.8 45.9 10.8 14.9 47.7 20.8 21.9 29.2 34.7 27.4 19.3 15.8 21.7 20.1 14.5 23.4 33.8 21.7 15.7 15.6 33.4 20.4 23.0 42.0 13.2 1.2 6.1 2.5 1.5 2.2 3.0 2.6 2.7 1.5 1.4 2.0 3.1 3.6 4.1 2.4 3.0 1.6 0.8 10.1 11.3 18.3 16.9 11.5 9.9 8.0 9.1 8.2 8.1 9.5 11.3 31.0 19.2 33.3 70.5 35.4 52.8 28.9 28.6 25.6 75.6 35.9 23.9 29.2 30.0 32.3 55.2 98.0 64.9 53.9 33.3 1.9 21.0 237.3 50.4 37.5 33.2 52.1 37.9 120.7 23.6 34.0 28.7 30.1 90.0 37.4 55.6 40.7 44.3 29.6 26.9 108.5 30.4 30.5 50.3 47.9 97.9 49.0 37.2 19.6 79.6 42.9 31.5 54.6 116.6 101.8 31.4 34.9 36.9 31.6 47.3 26.6 17.3 31.4 58.3 32.9 38.3 32.5 60.0 31.9 31.2 55.4 87.7 42.8 48.1 31.2 55.3 TRIM5 "RNF88, TRIM5alpha" ENSG00000132256 "Tripartite motif containing 5" Q9C035 11 5663195-5938619 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Antiviral defense, Autophagy, Host-virus interaction, Immunity, Innate immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "CAB013497, HPA023420, HPA023422" Approved Supported Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Cytosol "CAB013497: , HPA023420: AB_1856378, HPA023422: AB_1856379" "unprognostic (2.60e-1)" "unprognostic (9.62e-2)" "unprognostic (2.04e-2)" "unprognostic (1.41e-2)" "unprognostic (6.88e-2)" "unprognostic (4.74e-3)" "unprognostic (5.48e-3)" "unprognostic (5.82e-2)" "unprognostic (1.49e-1)" "unprognostic (6.76e-3)" "unprognostic (8.54e-3)" "unprognostic (1.64e-1)" "unprognostic (2.20e-2)" "unprognostic (1.90e-1)" "unprognostic (1.09e-1)" "unprognostic (1.07e-2)" "unprognostic (6.12e-2)" 8.8 10.9 2.1 8.1 2.3 3.8 8.0 2.0 2.4 11.8 7.2 7.2 7.4 11.7 18.4 7.7 9.4 6.9 5.7 2.0 3.3 9.0 12.8 11.8 8.4 4.0 3.5 11.4 13.3 4.2 3.8 9.6 3.4 8.5 7.7 1.9 14.0 9.1 1.9 5.5 8.5 11.3 3.0 10.4 7.8 8.3 3.5 9.4 9.6 4.0 8.9 8.2 8.6 2.9 7.7 15.4 19.2 12.4 24.0 22.5 5.4 18.0 35.0 37.3 50.0 13.8 13.5 5.5 13.3 18.8 27.6 13.0 18.4 25.8 14.9 9.6 5.1 15.2 10.4 9.5 20.2 11.5 15.3 15.4 22.7 10.5 31.3 22.9 52.8 8.9 16.9 12.2 32.1 4.2 7.7 5.3 7.7 11.7 8.1 14.3 4.7 1.5 23.7 14.4 0.5 1.1 11.8 18.4 6.8 20.7 9.3 6.6 43.3 13.9 20.2 3.6 4.2 9.4 7.9 1.9 10.9 6.8 15.4 10.7 7.6 11.6 3.6 7.8 3.0 3.1 2.8 2.8 9.4 2.6 1.8 3.7 7.7 4.1 8.0 7.0 2.2 4.1 2.1 2.3 2.0 2.4 2.0 3.3 4.0 3.5 3.4 3.0 3.5 2.9 14.2 6.4 14.0 4.9 8.7 5.2 9.5 9.7 9.6 0.2 8.3 6.5 4.9 2.8 13.4 11.0 0.0 7.8 16.4 5.5 5.9 10.6 5.0 8.6 12.6 14.8 1.2 8.4 3.0 8.8 10.5 12.4 6.1 12.5 0.0 11.9 15.4 13.9 6.4 0.0 1.4 9.7 4.1 12.2 7.1 3.8 7.8 10.8 3.6 19.7 10.8 7.0 14.4 3.0 1.0 8.1 4.9 7.5 6.7 10.1 7.4 6.3 3.7 0.1 19.7 6.5 10.9 5.2 3.3 7.0 5.4 7.8 7.5 20.6 7.5 9.9 TRIM63 "IRF, MURF-1, RNF28, SMRZ" ENSG00000158022 "Tripartite motif containing 63" Q969Q1 1 26051301-26068436 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Muscle protein, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "skeletal muscle: 1935.8" "Cell type enriched" "Detected in some" 7 "Cardiomyocytes: 272.2" "Cancer enriched" "Detected in some" 10 "melanoma: 31.0" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 40 "ASC diff: 16.1;SK-MEL-30: 55.7" "Not detected" "Not detected" "Region enhanced" "Detected in some" "cerebellum: 5.1" NA NA "Cluster 33: Striated muscle - Muscle contraction" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 54: Cardiomyocytes - Muscle contraction" "unprognostic (1.10e-1)" "unprognostic (4.80e-4)" "unprognostic (1.45e-2)" "unprognostic (7.52e-3)" "unprognostic (1.44e-1)" "unprognostic (2.05e-2)" "unprognostic (3.42e-1)" "unprognostic (1.12e-1)" "unprognostic (2.71e-1)" "unprognostic (1.06e-1)" "unprognostic (3.17e-1)" "unprognostic (1.01e-1)" "unprognostic (2.16e-2)" "unprognostic (5.90e-2)" "unprognostic (1.33e-2)" "unprognostic (2.32e-1)" "unprognostic (5.58e-2)" 1.2 0.2 0.0 0.0 0.1 0.0 0.8 0.0 0.1 1.5 0.0 0.7 0.3 8.8 0.3 7.1 0.6 2.7 243.0 0.0 0.0 1.5 0.4 1.3 0.0 0.1 0.1 0.2 0.8 0.0 0.2 4.0 0.0 1.5 0.2 0.1 9.6 0.4 1935.8 4.2 0.8 3.5 0.0 0.2 0.8 0.2 0.2 0.3 0.5 387.6 0.2 8.9 1.1 0.1 0.0 0.0 0.0 0.0 16.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.9 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 55.7 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.6 0.0 0.0 0.9 0.1 0.0 0.0 0.0 0.4 0.0 272.2 5.7 0.0 1.8 0.0 0.5 0.0 0.0 1.9 1.8 0.0 0.0 0.0 2.0 0.0 0.0 0.1 0.0 0.1 8.1 0.0 0.1 10.1 0.0 0.0 0.0 0.6 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.5 12.4 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.3 0.0 3.3 29.7 0.0 0.0 0.0 34.7 1.4 0.0 0.0 0.0 0.1 1.6 6.1 0.0 0.1 0.1 TRIO ARHGEF23 ENSG00000038382 "Trio Rho guanine nucleotide exchange factor" O75962 5 14143342-14532128 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Guanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 4 "Astrocytes: 205.7;Excitatory neurons: 400.9;Inhibitory neurons: 443.4;Microglial cells: 308.2;Oligodendrocyte precursor cells: 476.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "U-87 MG: 215.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008157, HPA064664" Supported Approved Vesicles,Cytosol No No "Cluster 15: NK-cells - Transcription" "Cluster 35: Non-specific - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol Vesicles "HPA008157: AB_1858327, HPA064664: AB_2685315" "unprognostic (6.65e-2)" "unprognostic (4.21e-3)" "unprognostic (1.65e-1)" "prognostic unfavorable (1.90e-4)" "unprognostic (9.39e-2)" "unprognostic (4.13e-1)" "unprognostic (2.18e-3)" "unprognostic (2.55e-1)" "unprognostic (7.52e-2)" "unprognostic (1.63e-1)" "unprognostic (2.02e-1)" "unprognostic (1.82e-1)" "prognostic unfavorable (3.11e-5)" "unprognostic (1.78e-2)" "unprognostic (1.96e-1)" "unprognostic (4.58e-3)" "unprognostic (2.23e-1)" 35.3 20.5 31.7 11.6 33.3 5.5 31.8 32.2 38.6 23.4 34.5 36.6 6.8 38.9 15.5 14.5 21.2 18.8 31.9 37.2 33.6 24.9 22.1 25.7 10.2 28.1 28.1 52.8 20.6 9.1 28.9 11.6 26.6 28.2 13.6 10.2 17.4 11.1 20.9 18.7 27.8 19.2 26.4 38.9 22.9 17.2 31.4 13.3 17.0 17.4 10.6 27.1 20.5 27.2 43.7 15.9 37.2 18.0 78.6 101.0 41.3 40.4 49.2 32.6 36.9 10.3 17.4 10.4 28.0 56.6 79.6 13.0 6.5 19.4 66.6 25.8 8.0 5.5 46.1 13.2 40.0 13.9 14.8 47.6 19.9 114.4 36.4 30.3 28.8 6.8 1.4 6.8 78.7 8.3 0.1 9.5 9.3 4.8 13.7 9.9 22.9 34.2 31.6 20.5 17.1 67.5 34.3 9.0 18.9 47.1 5.3 2.0 66.4 61.4 38.3 44.7 48.4 0.3 2.2 12.9 215.1 8.8 14.8 0.1 0.5 0.0 0.0 0.7 0.1 0.7 0.0 0.0 0.5 1.8 0.0 0.0 0.0 1.6 0.6 1.1 0.3 0.1 31.7 33.3 32.2 38.6 37.2 33.6 28.1 28.1 26.6 26.4 31.4 27.2 33.0 19.2 25.9 205.7 16.6 16.4 13.0 15.6 17.1 30.5 21.9 15.0 19.3 10.0 21.0 11.0 14.6 9.7 5.6 24.8 0.0 21.2 2.9 11.7 24.8 28.7 18.0 6.5 400.9 14.2 22.0 38.9 7.7 34.2 17.7 17.2 14.6 17.1 14.2 28.6 443.4 20.6 14.2 15.4 22.1 6.6 78.6 20.2 5.4 308.2 12.1 7.3 2.1 476.5 80.4 38.5 14.9 42.9 29.2 52.8 9.2 5.4 18.3 2.7 6.6 27.5 20.0 3.5 6.2 7.2 13.8 8.2 3.8 11.7 19.4 20.3 TRIP12 "KIAA0045, TRIPC, ULF" ENSG00000153827 "Thyroid hormone receptor interactor 12" Q14669 2 229763837-229923239 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Autism spectrum disorder, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 251.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036835, HPA045893" Enhanced Approved "Nuclear speckles" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 1: K-562 - Erythropoiesis" "Cluster 44: Endometrium - Transcription" "Nuclear speckles" "HPA036835: AB_2675340, HPA045893: AB_2679486" "unprognostic (1.22e-1)" "unprognostic (4.87e-2)" "unprognostic (2.61e-1)" "unprognostic (3.33e-2)" "unprognostic (6.81e-2)" "unprognostic (1.88e-1)" "prognostic unfavorable (3.60e-4)" "unprognostic (3.37e-3)" "unprognostic (3.49e-3)" "unprognostic (4.87e-2)" "unprognostic (5.21e-2)" "unprognostic (1.11e-1)" "unprognostic (1.22e-1)" "unprognostic (1.62e-1)" "unprognostic (6.83e-2)" "unprognostic (8.80e-2)" "unprognostic (2.01e-2)" 48.2 32.3 20.2 47.1 26.7 53.9 33.6 20.2 31.4 34.8 15.7 40.8 25.6 30.8 33.4 47.6 28.1 33.9 41.5 16.0 25.4 41.3 42.8 33.3 48.2 20.7 20.8 32.7 29.3 45.0 24.8 44.6 22.1 39.9 33.9 34.8 30.2 33.0 81.7 29.3 27.6 38.2 17.9 41.1 39.1 127.7 21.5 60.3 44.5 59.0 56.3 46.3 26.5 30.0 97.1 100.7 96.2 79.0 94.9 106.2 88.3 144.5 103.0 106.9 118.7 80.5 75.3 37.8 96.2 135.6 129.5 76.3 140.5 105.9 159.3 132.4 52.9 264.1 84.4 78.3 76.4 195.8 163.2 88.1 80.3 174.9 108.5 74.9 145.1 88.2 188.2 38.2 122.5 72.5 105.3 68.5 77.0 50.3 47.7 94.8 189.8 33.6 75.7 156.4 94.4 67.5 1.6 51.9 97.7 85.1 48.2 118.3 188.8 133.9 94.7 84.9 115.5 66.4 79.3 119.0 103.8 77.0 116.6 34.0 14.2 23.6 12.9 16.2 13.1 9.6 12.0 12.7 13.4 8.9 9.5 9.7 36.0 13.9 18.7 12.6 19.5 9.8 20.2 26.7 20.2 31.4 16.0 25.4 20.7 20.8 22.1 17.9 21.5 30.0 78.3 89.8 51.2 85.8 43.4 31.0 32.8 36.3 25.6 31.2 41.2 29.8 91.0 34.3 52.8 31.3 52.1 27.0 60.8 57.3 15.6 37.5 119.5 63.5 65.2 59.3 18.6 40.2 147.6 45.1 25.1 43.7 56.6 73.5 39.2 53.1 50.0 54.3 35.1 42.1 130.3 32.5 30.5 89.6 32.2 102.1 34.8 70.8 26.6 122.7 63.9 25.8 56.7 127.2 251.3 57.8 35.0 45.5 52.1 44.7 25.7 34.5 73.1 32.1 19.7 57.5 45.0 137.2 59.3 43.1 36.2 42.4 47.0 60.2 31.9 54.5 TRIT1 "FLJ20061, IPT" ENSG00000043514 "TRNA isopentenyltransferase 1" Q9H3H1 1 39838110-39883511 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "tRNA processing" Transferase "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA024174, HPA027330" Approved Supported Mitochondria NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 35: Non-specific - Unknown function" "Cluster 1: K-562 - Erythropoiesis" "Cluster 47: Cytotrophoblasts - Unknown function" Mitochondria "HPA024174: AB_1858346, HPA027330: " "unprognostic (4.61e-2)" "unprognostic (1.77e-1)" "unprognostic (8.38e-3)" "prognostic unfavorable (8.80e-4)" "unprognostic (4.00e-2)" "unprognostic (8.55e-2)" "prognostic unfavorable (5.34e-6)" "unprognostic (2.90e-1)" "unprognostic (2.21e-3)" "unprognostic (3.18e-2)" "unprognostic (3.54e-1)" "unprognostic (6.68e-3)" "prognostic unfavorable (7.08e-8)" "unprognostic (6.03e-2)" "unprognostic (1.11e-1)" "unprognostic (1.22e-1)" "unprognostic (6.90e-2)" 9.0 9.9 13.1 7.0 13.1 5.6 12.9 14.7 16.1 15.6 12.8 13.6 6.3 14.7 15.3 18.5 13.1 6.0 15.2 13.1 14.0 15.3 13.0 9.2 8.4 12.1 12.1 14.3 21.5 9.7 16.7 11.8 12.6 19.9 10.5 14.7 13.6 10.9 9.5 21.6 11.1 10.0 12.0 12.6 12.0 11.9 13.9 11.8 16.8 4.4 9.9 15.3 16.8 14.3 20.5 9.4 23.0 18.4 10.6 16.5 29.8 11.1 17.3 22.0 21.8 20.0 20.6 11.5 17.4 11.3 12.2 18.9 29.4 22.7 29.7 17.0 15.6 25.6 22.8 13.5 21.8 21.0 14.4 13.3 21.3 25.0 26.9 25.9 18.0 27.1 31.7 14.1 13.8 11.5 14.3 30.7 31.6 17.4 6.2 21.1 21.6 23.3 21.1 27.3 21.9 16.6 15.2 10.3 17.7 23.0 12.5 37.5 11.0 12.8 18.2 21.1 21.3 19.4 13.2 22.5 14.2 24.6 12.1 0.0 5.4 0.6 2.0 3.9 3.7 2.9 1.8 2.2 10.4 2.2 1.9 2.7 0.2 2.0 5.3 10.1 2.3 2.4 13.1 13.1 14.7 16.1 13.1 14.0 12.1 12.1 12.6 12.0 13.9 14.3 4.9 22.4 7.8 16.6 8.0 14.8 17.1 14.4 10.2 4.6 7.8 9.1 10.8 5.7 11.7 7.3 2.1 34.1 10.3 2.9 7.9 12.2 5.9 13.5 10.8 6.2 10.2 13.3 31.3 9.3 32.8 9.6 3.1 6.1 2.5 9.4 8.9 7.0 8.2 15.2 26.6 8.8 16.2 5.9 5.1 3.1 9.6 7.3 5.4 26.2 12.3 4.9 3.1 34.7 31.3 9.5 5.8 11.3 3.3 8.8 4.5 9.2 25.7 7.3 0.0 8.8 6.9 24.9 16.2 13.2 17.0 16.6 6.1 10.7 9.0 11.2 TRMT1 "FLJ20244, TRM1" ENSG00000104907 "TRNA methyltransferase 1" Q9NXH9 19 13104902-13117567 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "tRNA processing" "Methyltransferase, RNA-binding, Transferase, tRNA-binding" "Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Kupffer cells: 80.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041130, HPA041380" Approved Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 72: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 57: B-cells - Immune response" "Plasma membrane, Cytosol" Nucleoplasm "HPA041130: AB_10803995, HPA041380: AB_10793873" "unprognostic (2.10e-2)" "unprognostic (2.40e-3)" "unprognostic (2.23e-2)" "unprognostic (1.01e-1)" "unprognostic (1.12e-2)" "unprognostic (5.54e-2)" "unprognostic (1.08e-3)" "unprognostic (2.19e-2)" "unprognostic (1.59e-1)" "unprognostic (7.62e-2)" "unprognostic (1.91e-2)" "unprognostic (8.74e-3)" "prognostic unfavorable (9.87e-7)" "unprognostic (1.19e-3)" "unprognostic (3.47e-2)" "unprognostic (2.22e-1)" "unprognostic (2.49e-2)" 22.0 19.8 16.5 16.2 15.3 21.1 21.0 14.7 22.1 24.3 14.8 20.0 11.8 22.9 6.3 22.3 23.6 8.9 17.3 15.5 14.7 18.0 22.1 17.3 23.2 16.0 14.8 28.7 25.4 10.0 17.2 11.3 16.8 23.0 10.9 6.5 17.0 11.4 28.8 23.4 21.7 12.5 14.2 30.6 18.9 16.8 16.2 11.6 19.2 10.5 15.9 22.3 22.2 17.6 38.6 25.3 26.9 46.0 26.7 34.1 38.7 42.1 20.9 45.3 39.1 27.4 30.8 47.7 53.6 22.9 23.7 34.8 45.2 37.3 20.9 31.3 62.8 38.0 68.7 46.5 48.7 77.2 43.1 48.4 48.4 47.3 44.1 28.9 33.8 35.2 83.7 14.9 28.6 42.6 31.7 83.3 64.0 24.2 57.5 52.5 34.6 65.8 28.3 38.2 63.5 28.9 26.2 53.7 44.8 19.4 21.0 42.8 38.2 65.1 25.5 39.8 75.1 25.6 53.4 44.1 30.3 80.7 34.7 1.8 18.9 0.6 8.9 15.0 8.6 12.4 9.6 8.6 18.2 12.9 11.1 8.5 3.7 5.6 9.9 10.6 6.9 10.7 16.5 15.3 14.7 22.1 15.5 14.7 16.0 14.8 16.8 14.2 16.2 17.6 15.5 12.8 13.1 8.5 47.5 24.0 27.0 16.8 22.8 8.9 16.6 20.2 8.3 11.5 9.6 12.9 2.1 21.7 19.6 16.6 5.9 17.3 22.4 7.9 11.7 17.6 7.2 13.0 12.0 14.9 22.6 14.3 17.9 9.8 29.8 19.7 6.1 10.8 47.7 8.4 9.1 14.1 4.1 80.0 51.0 47.9 14.0 57.4 17.8 10.3 64.8 6.1 12.3 2.5 7.5 12.8 6.8 12.8 24.2 29.0 7.8 14.2 9.2 12.6 13.1 17.5 16.1 21.1 20.0 20.7 20.6 15.5 24.4 14.6 22.5 20.3 TRMT11 "C6orf75, dJ187J11.2, MDS024, TRM11, TRMT11-1" ENSG00000066651 "TRNA methyltransferase 11 homolog" Q7Z4G4 6 125986479-126203817 "Metabolic proteins, Predicted intracellular proteins" "tRNA processing" "Methyltransferase, RNA-binding, Transferase, tRNA-binding" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030473 Approved "Nuclear bodies" Yes No "Cluster 30: Non-specific - Translation" "Cluster 85: Liver - Metabolism" "Cluster 39: CACO-2 - Unknown function" "Cluster 9: Photoreceptor cells - Phototransduction" "Nuclear bodies" "HPA030473: AB_2673493" "unprognostic (2.55e-1)" "unprognostic (6.12e-3)" "unprognostic (1.44e-1)" "unprognostic (1.13e-2)" "unprognostic (7.62e-2)" "unprognostic (9.69e-2)" "unprognostic (2.12e-1)" "unprognostic (7.38e-2)" "unprognostic (3.54e-2)" "unprognostic (5.73e-2)" "unprognostic (7.35e-2)" "unprognostic (1.06e-2)" "unprognostic (4.74e-3)" "unprognostic (1.14e-1)" "unprognostic (1.30e-1)" "unprognostic (1.69e-1)" "unprognostic (2.06e-1)" 8.4 10.2 7.3 8.1 7.5 2.9 11.7 12.9 9.9 9.5 6.6 8.8 12.8 13.5 9.9 8.0 9.7 9.0 10.9 7.3 7.8 13.3 19.8 7.9 10.5 6.7 7.4 12.5 6.4 12.6 13.3 9.4 7.2 9.1 9.4 16.9 8.8 8.5 7.6 6.6 10.7 10.7 5.8 6.8 8.8 7.7 7.2 8.7 12.9 8.8 10.4 9.6 8.9 9.0 17.4 11.0 24.2 11.4 12.9 13.7 16.6 13.1 21.7 15.6 24.3 30.8 19.8 26.0 24.2 8.3 29.1 20.7 26.1 14.3 26.4 19.5 37.6 17.8 20.1 46.2 21.9 29.0 5.4 14.3 15.5 15.9 25.6 22.4 7.6 9.1 44.5 5.3 17.7 22.0 15.3 34.6 20.4 15.4 15.1 9.1 16.3 17.6 22.3 9.8 32.4 16.9 13.9 18.0 36.3 18.0 13.1 28.3 5.4 9.7 10.7 27.3 25.8 13.9 1.3 6.6 23.2 24.5 17.7 1.0 1.6 0.0 5.6 1.3 11.0 7.0 7.9 6.5 3.5 6.0 9.5 8.6 0.5 7.7 0.7 4.3 6.0 3.2 7.3 7.5 12.9 9.9 7.3 7.8 6.7 7.4 7.2 5.8 7.2 9.0 11.0 6.4 22.0 24.8 17.4 13.4 27.8 29.4 23.3 59.5 11.2 13.7 12.2 21.5 26.1 7.3 73.0 18.7 14.9 8.5 19.6 19.2 10.1 13.1 25.5 10.4 9.1 8.4 56.1 16.3 13.7 27.3 27.0 12.3 18.4 20.0 6.8 22.5 7.2 20.2 63.8 11.1 18.3 6.0 3.7 4.7 25.7 7.1 3.6 23.4 11.8 21.1 9.2 31.7 48.5 13.2 15.5 24.5 12.3 22.6 22.6 30.2 24.3 74.7 6.6 21.0 17.2 15.6 9.2 14.3 10.1 14.9 14.7 27.2 13.7 17.9 TRMT1L C1orf25 ENSG00000121486 "TRNA methyltransferase 1 like" Q7Z2T5 1 185118101-185157072 "Metabolic proteins, Predicted intracellular proteins" "Behavior, tRNA processing" "Methyltransferase, RNA-binding, Transferase, tRNA-binding" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 73.0;Spermatocytes: 103.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026728 Uncertain Approved Nucleoplasm,Nucleoli NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 23: Testis - Cell cycle regulation" "Cluster 16: U-266 - Nucleosome" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm Nucleoli "HPA026728: AB_1845641" "unprognostic (1.07e-2)" "unprognostic (1.31e-1)" "unprognostic (8.55e-3)" "unprognostic (2.96e-1)" "unprognostic (1.46e-2)" "unprognostic (8.95e-2)" "unprognostic (2.38e-1)" "unprognostic (4.41e-2)" "unprognostic (2.32e-1)" "unprognostic (2.46e-3)" "unprognostic (1.32e-1)" "unprognostic (8.75e-2)" "unprognostic (1.16e-2)" "unprognostic (7.44e-2)" "unprognostic (9.45e-2)" "unprognostic (7.87e-2)" "unprognostic (2.26e-1)" 6.8 8.6 7.8 8.4 9.1 5.7 7.6 9.7 9.7 7.9 9.1 7.7 8.5 7.3 9.4 6.9 10.6 7.0 12.1 7.6 8.4 13.1 14.5 7.4 10.8 8.7 8.2 11.4 5.0 12.1 7.0 8.2 8.9 7.6 7.2 8.9 5.6 8.1 20.8 4.8 7.0 6.9 9.1 10.6 7.2 27.7 8.2 10.2 10.4 18.7 11.9 7.0 5.5 12.3 12.4 22.3 15.1 11.3 21.8 20.0 21.5 11.7 10.5 15.7 16.4 20.4 23.1 13.5 28.5 8.1 24.0 15.6 25.7 15.3 15.4 16.1 11.2 13.0 15.9 20.9 15.2 19.3 20.6 9.6 20.3 16.1 16.1 16.6 17.5 17.9 34.5 18.0 18.9 10.5 14.7 11.2 24.9 25.3 4.6 17.1 21.7 21.6 15.2 13.5 13.4 12.0 22.8 22.0 16.2 34.2 22.4 10.7 16.9 14.3 11.4 9.9 15.8 28.7 41.5 21.3 9.4 16.8 14.0 24.0 10.6 21.9 7.5 14.7 8.1 12.3 9.9 9.3 13.3 18.1 12.3 9.7 12.3 12.8 19.2 5.5 14.2 9.2 7.8 9.1 9.7 9.7 7.6 8.4 8.7 8.2 8.9 9.1 8.2 12.3 8.2 12.8 15.6 24.2 18.0 2.7 8.1 11.6 7.4 8.7 6.9 6.5 29.5 11.5 15.1 16.5 8.4 16.3 10.0 8.9 27.4 12.2 73.0 22.4 8.9 11.7 6.1 29.0 19.8 6.0 9.9 12.0 10.7 8.2 8.8 14.5 11.0 25.0 13.0 3.3 19.6 9.2 12.2 17.5 6.2 25.0 12.5 13.7 1.8 20.6 16.3 9.6 6.2 18.6 36.8 7.6 10.9 12.0 10.7 5.9 9.6 23.9 44.2 8.6 0.0 11.0 9.6 103.8 32.0 9.7 2.4 11.4 10.7 13.6 8.3 5.3 TRMU "FLJ10140, MTO2, MTU1, TRMT" ENSG00000100416 "TRNA mitochondrial 2-thiouridylase" O75648 22 46330875-46357340 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "tRNA processing" "RNA-binding, Transferase, tRNA-binding" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000824, HPA035273, HPA043300" Uncertain Supported Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 52: Non-specific - Transcription" Mitochondria "HPA000824: AB_2732393, HPA035273: AB_10602901, HPA043300: AB_2678415" "unprognostic (2.96e-1)" "unprognostic (1.09e-2)" "unprognostic (8.07e-2)" "unprognostic (4.27e-2)" "unprognostic (2.64e-1)" "unprognostic (3.52e-3)" "prognostic unfavorable (3.04e-5)" "unprognostic (4.72e-2)" "unprognostic (7.14e-2)" "unprognostic (7.89e-2)" "prognostic favorable (6.86e-4)" "unprognostic (4.74e-3)" "prognostic unfavorable (5.63e-6)" "unprognostic (7.26e-2)" "unprognostic (1.73e-1)" "unprognostic (3.56e-1)" "unprognostic (7.44e-3)" 4.2 7.5 7.7 2.3 7.8 2.9 4.0 8.3 9.6 4.3 8.3 4.5 4.7 3.6 7.5 5.6 3.4 2.6 11.2 7.6 8.5 9.1 8.8 3.5 5.0 8.5 8.6 4.0 10.2 8.0 5.3 4.1 8.5 4.4 4.1 2.8 5.5 4.7 6.9 4.8 4.0 3.9 7.9 4.2 4.3 2.3 8.5 3.0 4.6 8.4 4.3 4.2 4.1 7.8 17.8 16.0 6.6 15.1 12.2 8.6 16.6 18.1 12.6 24.9 19.2 22.7 4.5 11.5 12.5 16.2 10.9 15.3 28.5 16.0 21.1 7.5 38.4 13.6 25.0 27.1 10.4 26.5 9.0 8.2 17.6 25.8 8.1 10.3 16.2 5.8 19.3 2.7 15.3 19.1 10.4 21.5 25.5 10.6 27.5 12.2 14.4 21.2 12.5 12.1 15.9 19.0 16.0 18.5 31.7 8.2 10.7 10.9 11.9 11.1 19.8 15.8 20.7 6.5 7.8 12.6 15.7 19.1 22.8 0.0 6.2 3.8 9.4 9.0 8.3 5.4 8.2 8.9 7.1 5.5 7.3 6.9 1.3 8.0 9.8 5.8 11.0 5.9 7.7 7.8 8.3 9.6 7.6 8.5 8.5 8.6 8.5 7.9 8.5 7.8 12.7 9.6 6.1 22.9 13.2 6.2 10.8 16.8 7.4 26.4 10.6 11.8 14.7 10.0 10.7 11.0 16.7 24.9 16.1 14.1 27.4 20.1 1.6 6.3 10.2 14.5 12.5 14.3 19.4 19.6 21.0 11.9 21.9 6.6 9.5 26.8 13.9 16.8 15.9 13.5 18.0 12.3 10.2 9.9 4.0 3.3 15.2 8.8 8.8 5.6 14.9 11.9 20.6 10.1 14.6 19.5 9.9 17.0 13.8 14.2 15.3 27.9 10.2 26.4 6.6 7.6 14.4 18.5 12.9 9.6 9.7 15.3 13.1 21.0 19.3 9.9 TRPM6 "CHAK2, FLJ22628, HOMG, HSH" ENSG00000119121 "Transient receptor potential cation channel subfamily M member 6" Q9BX84 9 74722495-74888094 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Primary hypomagnesemia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "brain: 6.6;intestine: 16.6" "Cell type enhanced" "Detected in many" "Distal enterocytes: 128.9;Glandular and luminal cells: 36.5;Microglial cells: 39.4;Oligodendrocytes: 81.1;Proximal enterocytes: 23.3" "Cancer enhanced" "Detected in some" "testis cancer: 1.8" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 6 "basophil: 23.1;neutrophil: 7.5" "Lineage enriched" "Detected in single" 41 "granulocytes: 23.1" "Cell line enhanced" "Detected in some" "BEWO: 3.8;HeLa: 2.4;Karpas-707: 1.3;RT4: 3.8;U-266/70: 1.4" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 15: RT4 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "unprognostic (3.95e-2)" "unprognostic (1.46e-1)" "unprognostic (1.76e-1)" "unprognostic (1.65e-1)" "unprognostic (7.80e-2)" "unprognostic (9.20e-2)" "unprognostic (1.59e-2)" "unprognostic (1.72e-1)" "unprognostic (2.82e-1)" "unprognostic (1.84e-1)" "unprognostic (5.72e-4)" "unprognostic (1.58e-1)" "unprognostic (1.71e-2)" "unprognostic (8.10e-2)" "unprognostic (7.54e-2)" "unprognostic (1.89e-2)" "unprognostic (2.11e-2)" 0.6 0.0 2.1 0.6 3.5 2.6 0.6 3.0 2.4 0.3 0.2 13.2 7.0 0.3 0.2 0.3 0.2 0.3 0.2 1.6 2.8 1.9 0.1 0.3 0.3 4.2 3.4 0.0 0.1 1.4 0.5 0.3 4.1 0.5 16.6 0.4 0.3 0.1 0.1 0.7 7.9 0.5 2.7 0.5 0.2 1.4 3.1 0.4 0.2 0.1 0.3 0.4 0.3 6.6 0.0 0.8 0.1 0.0 0.0 0.0 3.8 0.0 0.0 0.0 0.0 1.0 0.1 0.3 0.0 0.0 0.1 0.1 0.2 0.2 0.0 0.0 0.1 0.1 2.4 0.1 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.0 1.3 0.0 0.5 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.1 0.0 3.8 0.1 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.5 0.1 0.0 1.4 0.0 0.1 0.0 0.1 0.1 23.1 0.1 2.4 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.3 0.1 0.1 7.5 0.5 0.2 0.3 0.0 0.1 2.1 3.5 3.0 2.4 1.6 2.8 4.2 3.4 4.1 2.7 3.1 6.6 3.3 0.0 1.7 1.0 0.3 0.1 1.9 0.3 2.2 0.3 0.2 0.4 0.9 0.0 1.3 3.7 0.0 0.2 0.2 128.9 0.0 0.0 4.0 11.3 3.4 3.2 3.6 0.0 1.3 0.0 0.1 0.3 0.0 36.5 0.0 0.1 3.3 0.1 0.0 0.0 0.5 3.0 0.0 0.3 0.6 0.9 0.0 0.4 0.0 39.4 0.0 0.3 0.0 0.5 81.1 0.0 13.8 0.4 0.1 1.3 23.3 0.0 0.8 2.7 0.0 0.7 0.4 1.6 2.4 0.5 1.0 0.1 0.5 0.2 7.5 0.8 TRPM7 "CHAK1, LTRPC7, TRP-PLIK" ENSG00000092439 "Transient receptor potential cation channel subfamily M member 7" Q96QT4 15 50552473-50686797 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Necrosis, Transport" "Calcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase" "Amyotrophic lateral sclerosis, Neurodegeneration, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 108.9" "Cell type enhanced" "Detected in all" "Excitatory neurons: 122.2;Oligodendrocytes: 109.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-2197: 122.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035522, HPA052173" Enhanced Approved "Vesicles,Plasma membrane,Cytosol" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 18: U-2197 - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" "Vesicles, Cytosol" "HPA035522: , HPA052173: AB_2681749" "unprognostic (3.14e-2)" "unprognostic (1.86e-1)" "unprognostic (1.58e-1)" "unprognostic (1.42e-2)" "unprognostic (1.89e-1)" "unprognostic (1.60e-2)" "unprognostic (1.85e-2)" "unprognostic (2.59e-2)" "unprognostic (5.46e-3)" "unprognostic (2.64e-1)" "unprognostic (2.91e-1)" "unprognostic (1.59e-2)" "unprognostic (3.20e-2)" "unprognostic (2.08e-1)" "unprognostic (7.59e-2)" "unprognostic (9.45e-2)" "unprognostic (1.97e-1)" 11.5 9.6 4.3 13.3 6.5 21.4 13.6 15.4 6.7 10.3 29.3 13.8 14.4 12.7 14.6 8.6 9.4 11.1 15.5 4.8 3.5 22.9 25.3 11.6 16.6 4.9 3.9 16.4 12.2 108.9 5.3 13.3 5.9 10.9 14.4 10.5 10.9 10.6 7.8 16.6 13.1 11.4 3.2 12.2 13.6 9.9 6.4 15.5 17.3 9.1 14.4 11.4 8.1 10.4 21.4 21.0 17.2 19.1 48.5 36.2 20.9 26.4 36.7 16.5 21.6 29.1 11.6 46.4 12.7 30.8 42.5 35.1 23.3 19.5 23.4 26.0 13.7 37.1 31.5 15.4 44.0 38.8 27.6 33.9 22.4 18.8 35.0 24.0 13.5 28.8 42.6 34.5 30.4 33.7 25.1 18.8 13.0 29.4 12.8 27.2 23.7 22.7 23.0 49.9 14.2 18.1 18.2 28.7 35.8 30.1 18.0 41.6 20.7 26.1 12.4 122.4 30.8 23.3 54.9 44.0 28.4 77.5 24.8 1.8 1.3 1.6 2.5 1.3 2.9 2.2 1.8 1.7 1.5 2.3 1.6 1.9 1.7 2.4 1.4 1.9 2.0 0.8 4.3 6.5 15.4 6.7 4.8 3.5 4.9 3.9 5.9 3.2 6.4 10.4 23.9 19.2 31.3 73.1 36.4 31.6 17.2 11.0 44.9 21.9 18.8 11.9 25.9 21.5 8.2 12.9 12.5 23.0 38.4 17.0 3.9 11.7 33.3 21.6 27.1 19.7 18.5 29.6 122.2 12.7 9.4 26.1 37.8 23.1 17.7 26.0 14.6 43.9 14.6 21.9 92.7 19.5 6.1 22.4 19.8 26.0 26.4 26.5 19.6 66.5 24.2 8.5 29.9 80.9 109.1 15.5 13.9 20.3 33.2 24.9 23.4 11.0 19.3 22.6 13.1 30.0 22.0 23.1 23.6 25.7 24.2 16.3 34.5 22.2 20.4 11.1 TSSK1B "FKSG81, SPOGA4, STK22D, TSSK1" ENSG00000212122 "Testis specific serine kinase 1B" Q9BXA7 5 113432553-113434989 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Differentiation, Spermatogenesis" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 224 "testis: 53.6" "Group enriched" "Detected in some" 108 "Early spermatids: 490.9;Late spermatids: 1056.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA027827 Enhanced NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 25: Spermatids - Spermatogenesis" "HPA027827: AB_10603138" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 53.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 490.9 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1056.0 4.7 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.1 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TSSK2 "FLJ38613, SPOGA2, STK22B" ENSG00000206203 "Testis specific serine kinase 2" Q96PF2 22 19131308-19132622 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Differentiation, Spermatogenesis" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 231 "testis: 135.9" "Group enriched" "Detected in some" 94 "Early spermatids: 1657.2;Late spermatids: 3184.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "HaCaT: 1.0" "Not detected" "Not detected" "Low region specificity" "Detected in single" NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 17: WM-115 - Nervous system development" "Cluster 25: Spermatids - Spermatogenesis" 0.0 0.0 0.1 0.2 0.1 0.0 0.1 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.0 0.0 0.3 0.1 0.2 0.5 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.0 0.0 135.9 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.4 0.0 0.1 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.5 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.1 0.0 0.3 0.0 0.1 0.1 0.0 0.2 0.0 0.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.2 0.7 0.4 0.0 0.1 0.1 0.6 0.2 0.0 0.1 0.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.3 0.2 0.2 0.1 0.3 0.1 0.2 0.1 0.2 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1657.2 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3184.4 18.3 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.4 0.0 0.0 0.0 0.0 0.0 0.0 6.6 0.0 0.0 25.7 12.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TSSK3 "SPOGA3, STK22C" ENSG00000162526 "Testis specific serine kinase 3" Q96PN8 1 32351521-32364312 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Differentiation, Spermatogenesis" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "bone marrow: 12.7;testis: 34.0" "Group enriched" "Detected in some" 67 "Early spermatids: 335.4;Late spermatids: 1251.0" "Not detected" "Not detected" "Region enriched" "Detected in single" 4 "cerebellum: 2.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HeLa: 14.1" "Not detected" "Not detected" "Not detected" "Not detected" HPA037516 Approved "Nucleoplasm,Nucleoli,Nuclear bodies" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 23: Testis - Cell cycle regulation" "Cluster 20: HeLa - Mitochondria" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Nucleoli" "Nuclear bodies" "HPA037516: AB_2675517" "unprognostic (5.71e-2)" "unprognostic (1.42e-1)" "unprognostic (2.32e-1)" "unprognostic (1.37e-1)" "unprognostic (7.69e-2)" "unprognostic (2.02e-4)" "unprognostic (2.06e-1)" "unprognostic (1.98e-3)" "unprognostic (2.05e-2)" "unprognostic (1.11e-1)" "unprognostic (1.46e-2)" "unprognostic (9.20e-2)" "unprognostic (1.02e-3)" "unprognostic (1.11e-2)" "unprognostic (1.51e-1)" "unprognostic (1.88e-1)" "unprognostic (2.68e-3)" 2.3 2.7 0.1 2.5 0.2 12.7 2.0 2.2 0.4 2.9 0.3 2.1 3.4 2.3 0.0 1.3 2.7 1.8 1.5 0.1 0.0 1.9 2.7 2.7 3.8 0.5 0.0 3.0 2.1 0.0 1.7 0.7 0.2 2.1 0.0 4.3 2.4 0.0 3.0 4.7 4.0 0.1 0.0 4.3 2.2 34.0 0.2 0.0 2.3 0.0 0.0 1.7 2.3 0.5 2.4 2.8 6.0 3.6 0.0 0.8 5.2 0.6 0.9 0.0 0.0 0.5 1.3 1.4 0.8 0.0 1.0 3.5 0.0 0.0 0.0 3.6 6.8 2.8 14.1 4.3 3.3 1.3 3.2 0.1 0.7 0.0 1.0 6.7 0.0 4.5 3.5 5.5 0.0 0.7 1.5 1.5 1.1 0.5 1.6 2.1 1.6 4.7 0.0 2.4 1.7 3.8 0.8 3.0 3.9 4.5 1.8 2.4 2.4 2.1 2.9 3.0 2.4 7.6 3.3 1.9 3.5 4.3 0.7 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.2 2.2 0.4 0.1 0.0 0.5 0.0 0.2 0.0 0.2 0.5 0.4 0.0 0.5 0.7 0.3 0.1 0.4 0.3 0.0 0.2 0.2 0.3 0.3 0.0 0.1 0.0 0.0 0.2 0.2 0.1 0.0 0.3 335.4 0.4 0.6 0.5 0.0 0.0 0.0 0.7 0.1 0.3 0.0 0.5 0.0 1.4 0.7 0.1 0.1 0.0 0.0 0.5 0.0 0.0 0.0 1251.0 9.3 0.3 0.0 0.0 0.5 0.6 0.0 0.0 0.1 0.3 0.1 9.4 0.0 0.2 0.7 0.8 0.8 1.2 6.6 0.2 0.2 11.7 3.7 0.0 0.0 0.3 0.2 0.5 0.3 0.3 TSSK4 "C14orf20, STK22E" ENSG00000139908 "Testis specific serine kinase 4" Q6SA08 14 24205696-24208362 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Differentiation, Spermatogenesis" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 9 "testis: 38.1" "Cell type enriched" "Detected in some" 9 "Early spermatids: 253.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA060660, HPA077103" Approved Approved "Cell Junctions" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 83: Testis - Spermatogenesis" "Cluster 20: HeLa - Mitochondria" "Cluster 23: Spermatids - Flagellum & Golgi organization" "Cell Junctions" "HPA060660: AB_2684339, HPA077103: AB_2732332" "unprognostic (1.95e-1)" "unprognostic (4.30e-2)" "unprognostic (1.52e-1)" "unprognostic (5.69e-2)" "unprognostic (2.36e-1)" "unprognostic (3.38e-5)" "unprognostic (1.06e-1)" "unprognostic (6.25e-3)" "unprognostic (1.64e-1)" "unprognostic (3.39e-1)" "unprognostic (7.03e-3)" "unprognostic (1.27e-3)" "unprognostic (3.42e-1)" "unprognostic (4.30e-2)" "unprognostic (6.28e-2)" "unprognostic (8.98e-2)" "unprognostic (7.26e-2)" 1.0 1.1 0.7 2.0 0.4 3.4 1.0 1.0 0.3 1.4 0.0 1.4 1.6 1.1 0.3 1.3 1.2 1.6 0.7 0.6 0.1 0.8 0.6 1.0 2.7 0.3 0.3 1.1 1.5 0.0 0.9 0.4 0.3 0.9 0.0 3.1 1.5 0.0 1.3 4.2 1.7 0.0 0.2 1.7 1.2 38.1 0.3 0.0 1.4 0.0 0.0 1.1 1.1 0.3 0.6 2.3 2.2 0.8 0.0 0.0 2.4 0.9 0.0 0.0 0.0 1.3 2.2 1.8 0.5 0.1 0.4 2.1 0.0 0.1 0.0 0.9 1.7 2.0 3.4 1.7 0.0 1.0 2.1 0.0 0.0 0.0 0.3 1.9 0.0 2.1 0.8 1.2 0.0 2.2 2.1 1.1 0.4 0.5 1.8 1.8 0.8 1.5 0.0 3.0 1.2 1.2 1.7 1.4 0.4 0.9 1.0 1.0 0.9 1.6 1.0 2.1 0.7 2.3 3.0 2.6 0.5 1.6 0.5 0.0 0.2 0.4 0.4 0.2 0.1 0.3 0.3 0.3 0.1 0.3 0.3 0.3 0.3 0.5 0.1 0.3 0.1 0.1 0.7 0.4 1.0 0.3 0.6 0.1 0.3 0.3 0.3 0.2 0.3 0.3 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 253.7 0.3 0.1 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 26.5 1.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.2 0.1 0.1 0.3 0.1 0.8 0.0 0.0 0.2 0.1 6.8 0.8 0.0 0.0 0.1 0.1 0.1 0.0 0.0 TSSK6 "CT72, FLJ24002, SSTK" ENSG00000178093 "Testis specific serine kinase 6" Q9BXA6 19 19512418-19515548 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Differentiation, Spermatogenesis" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 102 "testis: 167.6" "Cell type enriched" "Detected in some" 5 "Late spermatids: 8709.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 3.4;CACO-2: 1.7" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 83: Testis - Spermatogenesis" "Cluster 28: BEWO - Transcription regulation" "Cluster 25: Spermatids - Spermatogenesis" "unprognostic (2.12e-1)" "unprognostic (7.89e-2)" "unprognostic (7.26e-2)" "unprognostic (6.64e-2)" "unprognostic (3.39e-1)" "unprognostic (7.20e-5)" "unprognostic (3.38e-1)" "unprognostic (5.51e-3)" "unprognostic (5.17e-2)" "unprognostic (1.46e-1)" "unprognostic (3.98e-4)" "unprognostic (2.28e-2)" "unprognostic (5.34e-3)" "unprognostic (2.74e-3)" "unprognostic (2.78e-2)" "unprognostic (1.52e-3)" "unprognostic (9.89e-2)" 0.6 0.7 0.4 0.0 0.6 0.1 0.7 0.5 0.5 0.4 0.1 0.7 0.5 0.8 0.0 0.7 0.6 0.0 0.3 0.3 0.2 0.9 1.2 0.4 0.3 0.7 0.6 0.5 1.0 0.0 0.7 0.0 0.7 0.9 0.0 0.0 0.6 0.0 0.3 1.6 1.0 0.0 0.6 1.2 0.9 167.6 0.5 0.1 0.9 0.0 0.1 0.6 0.6 1.0 0.0 0.6 0.0 0.0 0.0 0.1 3.4 0.1 0.2 0.0 0.1 1.7 0.0 0.7 0.1 0.0 0.0 0.4 0.1 0.6 0.0 0.5 0.0 0.4 0.4 0.0 0.4 0.4 0.7 0.3 0.1 0.2 0.5 0.0 0.1 0.0 0.2 0.0 0.0 0.2 0.3 0.7 0.3 0.0 0.0 0.6 0.0 0.5 0.0 0.2 0.2 0.4 0.0 0.0 0.0 0.0 0.6 0.5 0.0 0.5 0.2 0.9 0.2 0.8 0.6 0.0 0.7 0.4 0.9 0.0 0.1 0.3 0.1 0.0 0.1 0.7 0.0 0.2 0.0 0.1 0.8 0.4 0.1 0.0 0.0 0.2 0.1 0.2 0.4 0.6 0.5 0.5 0.3 0.2 0.7 0.6 0.7 0.6 0.5 1.0 0.2 0.0 0.0 0.0 0.0 0.4 0.2 0.1 0.0 0.0 0.3 0.1 1.7 1.5 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.2 1462.5 0.5 0.4 2.7 0.0 0.0 0.0 0.2 0.1 0.1 0.0 0.8 0.0 0.1 0.7 0.5 0.1 0.0 0.0 0.0 2.0 0.8 0.5 8709.8 47.8 2.2 1.8 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 57.2 0.1 0.1 0.5 0.2 0.3 0.0 19.7 1.1 0.3 57.7 25.7 0.0 0.1 0.1 0.2 0.0 0.1 0.1 TTC3 "DCRR1, RNF105, TPRD, TPRDI, TPRDII, TPRDIII" ENSG00000182670 "Tetratricopeptide repeat domain 3" P53804 21 37073226-37203112 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016810, HPA023964, HPA036304" Uncertain Approved Nucleoplasm,Nucleoli,Cytosol No No "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 51: Non-specific - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "Nucleoplasm, Nucleoli" Cytosol "HPA016810: AB_1858434, HPA023964: AB_1858435, HPA036304: AB_2675049" "unprognostic (3.90e-2)" "unprognostic (1.65e-1)" "unprognostic (1.19e-1)" "unprognostic (1.22e-1)" "unprognostic (1.53e-1)" "unprognostic (1.37e-2)" "unprognostic (8.52e-2)" "unprognostic (9.29e-2)" "unprognostic (8.71e-2)" "unprognostic (1.61e-1)" "unprognostic (2.05e-2)" "unprognostic (1.99e-1)" "unprognostic (9.10e-2)" "unprognostic (1.02e-1)" "unprognostic (1.60e-1)" "unprognostic (1.39e-1)" "unprognostic (6.74e-2)" 45.8 29.3 28.1 27.1 25.0 26.4 43.1 36.3 35.3 59.3 45.7 34.6 24.7 38.9 58.6 27.9 34.9 35.4 28.0 38.9 15.5 37.7 31.7 24.4 29.4 10.0 11.1 60.6 42.9 39.1 35.6 29.0 11.8 51.2 36.3 63.0 50.0 41.4 27.7 30.7 30.3 34.6 6.7 27.3 40.9 27.4 15.3 38.0 64.8 30.6 29.2 30.6 9.4 21.4 72.9 25.4 115.3 22.2 108.9 156.8 40.0 77.5 96.0 34.2 46.1 34.0 35.8 62.3 26.6 130.9 32.1 23.3 35.3 47.9 48.2 66.3 25.0 125.6 38.0 44.1 39.6 70.9 39.1 81.9 28.8 35.0 31.0 68.8 51.6 54.1 77.3 71.1 65.2 56.0 69.4 18.8 33.3 48.0 42.6 91.6 55.3 33.2 39.4 55.3 87.7 67.6 97.2 55.2 49.1 26.5 62.2 27.3 68.3 49.2 19.5 61.2 30.4 71.1 55.1 60.6 80.7 69.9 37.9 4.8 6.2 6.8 11.5 6.4 17.1 13.0 13.3 15.8 10.8 15.1 23.2 14.4 1.0 12.8 8.6 17.3 10.0 4.8 28.1 25.0 36.3 35.3 38.9 15.5 10.0 11.1 11.8 6.7 15.3 21.4 78.3 125.0 142.7 161.3 144.8 65.9 94.8 102.7 86.0 347.7 175.8 140.1 134.7 68.6 118.2 75.4 227.2 50.1 129.5 67.8 166.3 91.1 192.7 115.0 217.4 78.9 190.2 65.4 424.5 75.3 93.5 171.0 131.5 132.0 64.6 256.8 99.6 94.4 61.4 329.7 396.0 163.1 99.7 95.2 83.7 192.4 210.0 86.8 211.7 111.5 87.4 196.5 93.7 321.7 261.9 73.3 96.5 261.1 167.6 121.4 72.8 96.1 108.6 233.9 52.6 245.8 127.9 400.0 258.4 91.7 62.8 52.7 109.7 204.1 148.1 103.9 TTK "CT96, MPH1, MPS1, MPS1L1" ENSG00000112742 "TTK protein kinase" P33981 6 80003887-80042527 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "bone marrow: 25.3;lymphoid tissue: 46.6;testis: 34.3" "Cell type enhanced" "Detected in many" "Early spermatids: 43.3;Erythroid cells: 23.1;Late spermatids: 21.4;Spermatocytes: 130.5;Spermatogonia: 33.0" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "T-reg: 1.2" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in single" "CAB010166, CAB013229" Enhanced Approved Nucleoli,Cytosol NA Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" "Nucleoli, Cytosol" "CAB010166: AB_632567, CAB013229: AB_2533230" "unprognostic (4.27e-2)" "unprognostic (8.71e-2)" "unprognostic (1.04e-2)" "prognostic unfavorable (1.44e-5)" "unprognostic (7.97e-2)" "unprognostic (4.78e-2)" "prognostic unfavorable (3.84e-10)" "unprognostic (1.56e-3)" "unprognostic (7.95e-2)" "unprognostic (2.02e-3)" "prognostic unfavorable (2.54e-4)" "unprognostic (1.54e-1)" "unprognostic (0.00e+0)" "unprognostic (3.51e-2)" "unprognostic (1.06e-1)" "unprognostic (1.46e-1)" "unprognostic (1.66e-1)" 0.7 0.8 0.0 4.2 0.1 25.3 2.2 0.1 0.3 0.7 0.0 4.8 4.0 1.0 0.1 4.8 0.6 0.5 0.1 0.1 0.1 0.2 0.5 0.8 8.1 0.2 0.1 0.2 0.2 0.3 0.0 3.9 0.2 0.8 5.9 1.8 0.7 0.1 0.0 3.6 4.1 1.7 0.1 1.4 3.3 34.3 0.2 46.6 0.4 0.1 9.0 1.2 1.4 0.2 39.9 23.4 68.2 56.4 3.1 9.5 38.5 44.9 27.4 64.2 77.8 32.1 29.6 58.5 34.1 19.5 66.9 50.0 60.7 27.6 88.6 53.4 49.3 54.1 29.4 26.5 0.2 64.4 33.9 1.2 2.8 45.0 28.6 9.6 36.9 80.6 60.2 58.5 55.2 29.5 37.0 46.4 40.4 35.4 27.9 32.7 124.4 24.4 16.3 25.2 46.8 27.4 26.6 28.3 16.3 36.6 26.6 48.3 15.4 28.8 28.5 18.8 72.9 13.1 47.1 32.4 10.3 58.9 25.1 0.0 0.0 0.3 0.1 0.0 0.1 0.2 0.2 0.4 0.0 0.7 0.0 0.1 0.0 0.3 0.0 0.0 1.2 0.2 0.0 0.1 0.1 0.3 0.1 0.1 0.2 0.1 0.2 0.1 0.2 0.2 0.3 3.2 1.1 0.0 1.4 1.3 0.6 2.6 0.0 0.2 0.9 0.5 0.6 0.0 2.3 0.0 2.1 9.8 0.8 2.2 3.9 0.4 43.3 3.1 1.6 1.1 1.8 23.1 0.2 0.2 15.0 2.1 2.6 2.3 1.3 13.9 0.7 0.2 6.5 0.0 0.2 3.0 4.1 2.6 1.2 21.4 0.9 1.9 0.0 0.0 5.2 0.2 1.0 0.0 0.1 0.6 0.2 0.7 5.1 0.4 0.3 0.1 3.0 1.6 6.6 0.1 1.7 130.5 33.0 8.5 0.3 3.7 1.1 0.5 5.6 1.6 TTL MGC46235 ENSG00000114999 "Tubulin tyrosine ligase" Q8NG68 2 112482156-112541739 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Ligase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Oligodendrocytes: 72.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" HPA066819 Approved Nucleoplasm,Vesicles NA NA "Cluster 17: Basophils - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Vesicles Nucleoplasm "HPA066819: AB_2685728" "unprognostic (1.05e-2)" "unprognostic (3.90e-3)" "unprognostic (2.25e-1)" "unprognostic (3.95e-3)" "unprognostic (9.75e-2)" "unprognostic (1.81e-2)" "prognostic unfavorable (5.65e-4)" "unprognostic (2.95e-1)" "unprognostic (3.65e-1)" "unprognostic (2.10e-1)" "unprognostic (5.48e-2)" "unprognostic (7.19e-2)" "unprognostic (6.12e-2)" "unprognostic (1.30e-1)" "unprognostic (1.45e-1)" "unprognostic (2.01e-1)" "unprognostic (4.55e-2)" 1.0 0.8 2.3 0.9 3.0 1.8 0.6 1.6 3.0 0.6 0.1 0.8 0.6 1.0 0.8 1.1 0.5 1.1 1.6 2.4 1.7 0.8 0.6 1.3 1.0 1.5 1.9 0.6 0.8 0.8 0.3 1.2 1.6 0.6 0.8 1.4 0.4 0.7 3.7 1.4 0.6 1.3 0.8 0.9 0.6 0.6 2.7 1.0 0.9 3.8 0.8 1.0 0.4 3.5 2.9 2.2 2.7 6.2 3.2 4.6 1.1 4.9 4.0 5.1 4.4 2.7 1.0 2.7 2.7 4.2 3.3 2.0 4.8 2.5 6.2 1.9 2.7 2.3 3.1 3.4 1.4 3.2 1.1 2.1 1.7 7.5 4.0 2.3 4.4 1.8 3.8 2.1 4.1 1.5 2.8 1.8 2.4 0.8 4.4 3.0 3.1 1.5 1.6 2.2 5.8 4.0 3.8 1.2 6.7 1.8 1.3 1.8 4.4 6.0 4.4 4.8 3.7 1.1 2.5 2.2 6.7 2.4 2.6 0.6 0.2 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.0 0.2 0.1 0.1 0.3 0.1 0.2 0.2 0.1 0.0 2.3 3.0 1.6 3.0 2.4 1.7 1.5 1.9 1.6 0.8 2.7 3.5 14.0 12.8 6.4 19.2 7.0 20.3 4.9 8.3 4.6 15.6 6.4 6.0 39.1 2.8 6.7 12.9 12.5 3.2 10.6 8.0 0.0 7.2 12.2 8.3 28.3 18.5 11.3 16.2 34.1 9.6 2.4 12.6 2.6 10.8 0.0 11.7 15.7 10.4 11.4 8.4 24.0 5.8 16.2 24.2 19.2 5.1 3.1 17.0 7.2 20.6 17.2 9.8 8.2 24.6 72.8 9.4 5.2 5.7 9.1 6.6 2.4 6.0 4.2 20.2 6.6 15.4 12.2 4.5 5.0 6.5 18.0 1.2 7.6 7.7 6.1 4.1 TTLL10 "FLJ36119, TTLL5" ENSG00000162571 "Tubulin tyrosine ligase like 10" Q6ZVT0 1 1173880-1197936 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "choroid plexus: 13.1;fallopian tube: 10.7;testis: 41.9" "Group enriched" "Detected in many" 6 "Early spermatids: 244.1;Late spermatids: 768.4" "Cancer enhanced" "Detected in some" "cervical cancer: 1.5;endometrial cancer: 1.5" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 32 "SCLC-21H: 38.5" "Not detected" "Not detected" "Not detected" "Not detected" HPA042712 Uncertain NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 49: Ciliated cells - Cilium organization" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 25: Spermatids - Spermatogenesis" "HPA042712: AB_10797019" "unprognostic (1.74e-1)" "unprognostic (7.95e-2)" "unprognostic (2.66e-3)" "prognostic favorable (1.61e-5)" "unprognostic (5.33e-2)" "unprognostic (2.68e-3)" "unprognostic (4.93e-3)" "unprognostic (2.14e-3)" "unprognostic (4.50e-1)" "unprognostic (3.69e-2)" "unprognostic (1.28e-2)" "unprognostic (6.63e-2)" "unprognostic (6.00e-4)" "unprognostic (8.35e-2)" "unprognostic (2.65e-1)" "unprognostic (1.12e-1)" "unprognostic (4.39e-2)" 1.3 0.0 0.6 0.1 0.4 0.0 1.1 0.2 0.4 1.7 13.1 0.2 0.1 0.2 0.4 0.3 10.7 0.3 0.2 0.8 0.9 0.4 0.0 2.8 0.1 2.6 3.7 0.0 0.3 0.0 2.1 1.5 1.8 0.3 0.1 0.0 0.3 0.1 0.4 0.2 0.2 0.0 2.0 0.1 0.5 41.9 0.9 0.0 0.2 0.0 0.0 0.2 0.1 0.6 0.3 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 38.5 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.6 0.4 0.2 0.4 0.8 0.9 2.6 3.7 1.8 2.0 0.9 0.6 14.4 0.0 0.5 0.0 0.3 1.8 0.7 3.0 0.0 0.1 1.4 1.0 0.8 1.5 3.4 0.0 2.1 0.0 0.9 0.9 0.0 0.5 244.1 52.2 0.6 2.1 0.0 0.0 0.2 1.3 1.0 0.3 3.6 6.5 0.0 0.0 0.4 0.0 0.0 0.0 0.1 3.1 0.0 0.0 1.1 768.4 5.3 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.1 1.5 1.0 4.5 0.0 1.5 0.4 0.1 72.5 0.1 6.6 0.9 1.0 9.3 2.1 1.0 2.0 0.1 0.9 0.0 3.6 1.3 TTN "CMD1G, CMH9, CMPD4, FLJ32040, LGMD2J, MYLK5, TMD" ENSG00000155657 Titin Q8WZ42 2 178525989-178830802 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cardiomyopathy, Disease variant, Limb-girdle muscular dystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 167.2;skeletal muscle: 920.6;tongue: 369.5" "Cell type enriched" "Detected in many" 16 "Cardiomyocytes: 24394.9" "Cancer enriched" "Detected in single" 4 "head and neck cancer: 1.3" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "RH-30: 1.9" "Not detected" "Not detected" "HPA007042, CAB022682, HPA030048" Enhanced NA NA 16000000 "Cluster 15: NK-cells - Transcription" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 54: Cardiomyocytes - Muscle contraction" "CAB022682: , HPA007042: AB_1080292, HPA030048: AB_2732451" "unprognostic (1.00e-2)" "unprognostic (3.92e-1)" "unprognostic (1.77e-1)" "unprognostic (7.11e-2)" "unprognostic (3.71e-2)" "unprognostic (1.49e-2)" "unprognostic (6.62e-2)" "unprognostic (1.84e-1)" "unprognostic (2.49e-2)" "unprognostic (1.86e-1)" "unprognostic (2.79e-1)" "unprognostic (2.65e-1)" "unprognostic (3.49e-4)" "unprognostic (1.99e-1)" "unprognostic (1.15e-1)" "unprognostic (1.09e-1)" "unprognostic (1.34e-2)" 0.6 0.4 2.7 0.5 2.4 4.3 0.5 2.8 4.9 0.3 0.0 0.4 0.4 0.4 0.2 2.7 0.3 0.7 167.2 1.9 3.4 0.2 0.3 1.2 1.4 11.2 4.4 0.7 1.7 0.0 0.8 0.5 6.6 2.7 0.0 1.9 7.0 0.0 920.6 0.8 0.6 0.0 3.2 0.7 0.4 1.6 4.8 0.7 0.6 369.5 0.4 0.2 0.3 5.3 0.3 0.1 0.7 0.4 0.0 0.0 1.4 0.2 0.0 0.0 0.0 0.7 0.1 1.0 0.2 0.0 0.7 0.7 0.0 0.0 0.0 1.0 0.8 1.5 1.3 0.4 0.0 0.1 0.3 0.9 0.0 0.0 0.0 0.7 0.6 0.7 0.9 0.5 0.1 0.2 0.7 1.0 0.2 0.1 0.7 0.5 1.9 0.6 0.0 0.2 0.4 0.7 0.1 0.5 0.0 0.6 0.3 1.0 0.7 0.0 0.0 0.3 0.2 1.4 0.2 1.4 0.0 0.5 0.3 1.8 0.2 0.5 0.4 0.2 0.1 6.1 0.9 0.7 0.1 5.7 2.0 2.6 1.0 3.6 0.2 0.2 6.0 0.1 2.7 2.4 2.8 4.9 1.9 3.4 11.2 4.4 6.6 3.2 4.8 5.3 10.9 16.0 173.4 43.8 32.1 0.9 1.6 0.0 2.8 102.7 1.7 0.5 24394.9 30.0 6.2 0.0 20.9 0.7 6.8 0.1 1.9 14.1 43.2 3.4 6.8 99.1 4.2 3.0 25.1 28.3 0.3 502.5 3.6 7.2 10.1 0.7 2.5 0.6 0.3 16.8 31.3 0.1 0.0 0.8 0.8 6.4 1.2 26.2 0.0 25.3 0.6 12.0 2.1 11.6 4.9 0.5 0.1 4.5 10.6 0.2 0.3 0.4 2.9 27.8 0.0 1466.9 104.7 9.3 1.5 2.3 0.1 0.4 24.3 2.8 0.5 0.1 UBA1 "A1S9T, CFAP124, GXP1, POC20, UBE1, UBE1X" ENSG00000130985 "Ubiquitin like modifier activating enzyme 1" P22314 X 47190861-47215128 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Ligase "Cancer-related genes, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000289, HPA001506, CAB019435, CAB073410" Approved Supported Nucleoplasm NA NA 14000000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "CAB019435: AB_2211440, CAB073410: , HPA000289: AB_1080443, HPA001506: AB_2756305" "unprognostic (7.18e-3)" "unprognostic (1.52e-1)" "unprognostic (7.54e-2)" "unprognostic (2.40e-1)" "unprognostic (9.29e-2)" "unprognostic (1.02e-1)" "prognostic unfavorable (6.10e-5)" "unprognostic (7.22e-2)" "unprognostic (2.42e-3)" "unprognostic (3.43e-2)" "unprognostic (8.50e-3)" "unprognostic (2.17e-3)" "unprognostic (1.85e-3)" "unprognostic (1.13e-1)" "unprognostic (5.38e-2)" "prognostic favorable (1.78e-4)" "unprognostic (1.21e-2)" 98.4 157.9 102.9 98.3 113.2 94.3 98.6 103.4 115.5 127.9 133.9 101.1 71.3 127.1 64.3 155.3 119.3 64.9 117.4 106.2 102.0 131.2 114.7 109.5 105.0 106.9 104.2 136.5 89.0 107.5 135.2 67.4 109.3 103.2 68.5 95.6 119.5 78.9 201.1 119.5 100.4 117.4 94.4 131.9 98.6 98.7 110.0 119.7 160.1 114.1 110.8 101.1 124.8 121.3 269.1 273.2 307.7 471.9 207.4 186.8 135.0 175.1 187.1 248.6 200.5 219.3 201.3 201.6 111.8 357.0 361.5 254.9 392.9 375.7 180.9 163.4 391.7 126.1 295.2 180.0 145.1 215.2 258.8 177.4 193.2 362.7 279.4 176.7 330.2 236.1 138.9 173.7 250.4 343.4 203.3 188.5 329.6 163.2 417.1 233.1 215.3 343.7 198.7 287.0 197.4 148.1 520.8 250.9 116.9 329.9 349.5 130.3 241.6 183.1 210.7 266.4 166.1 117.6 132.8 286.3 189.4 150.8 224.9 31.0 39.7 40.7 39.4 51.1 34.0 39.8 31.8 35.0 43.2 29.9 24.7 31.1 44.8 38.1 49.7 29.3 40.3 39.9 102.9 113.2 103.4 115.5 106.2 102.0 106.9 104.2 109.3 94.4 110.0 121.3 37.2 51.3 34.7 45.1 37.1 33.6 38.6 55.7 26.2 24.9 48.3 39.6 51.4 51.5 50.0 82.8 16.7 46.3 34.2 133.1 35.2 77.5 29.6 84.9 56.3 40.9 57.5 33.2 27.1 90.8 68.7 45.0 74.9 97.5 18.3 60.3 43.5 51.2 60.0 11.8 35.5 78.6 30.5 49.0 37.8 61.6 42.3 51.4 19.6 31.9 57.7 20.7 13.4 32.2 46.5 147.9 74.7 65.8 44.0 55.2 82.2 61.6 56.4 25.1 39.5 38.8 56.6 10.5 34.0 51.3 42.1 71.1 34.6 56.8 68.2 55.4 UBA2 "FLJ13058, HRIHFB2115, SAE2" ENSG00000126261 "Ubiquitin like modifier activating enzyme 2" Q9UBT2 19 34428352-34471251 "Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Sertoli cells: 269.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041436 Supported Supported Nucleoplasm NA NA 130000 "Cluster 26: Non-specific - Mitochondria" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 48: Smooth muscle cells - ECM organization" Nucleoplasm "HPA041436: AB_2677479" "unprognostic (2.37e-1)" "unprognostic (3.17e-1)" "unprognostic (2.13e-2)" "unprognostic (1.36e-3)" "unprognostic (6.39e-3)" "unprognostic (8.72e-3)" "prognostic unfavorable (3.76e-4)" "unprognostic (1.96e-2)" "unprognostic (2.14e-2)" "unprognostic (1.21e-1)" "unprognostic (2.58e-1)" "unprognostic (2.65e-2)" "prognostic unfavorable (8.02e-4)" "unprognostic (1.63e-2)" "unprognostic (2.11e-2)" "unprognostic (2.00e-1)" "unprognostic (1.88e-1)" 91.3 36.8 35.9 37.1 37.1 54.9 67.7 44.6 53.1 52.4 35.1 41.6 27.4 55.3 34.8 43.6 47.9 35.7 43.3 36.4 39.3 36.5 36.0 45.3 57.2 36.9 39.1 51.7 40.4 40.8 38.5 60.6 36.5 33.6 35.1 47.2 34.4 34.3 109.4 54.5 37.0 43.0 36.9 32.4 38.6 91.8 38.3 68.5 41.8 57.8 54.8 45.7 46.1 40.7 122.9 175.7 176.2 73.4 93.5 75.8 72.0 93.5 80.0 118.2 130.9 151.7 72.7 227.4 140.3 76.7 73.4 48.8 188.8 72.9 165.4 164.0 126.7 241.6 84.6 152.9 120.3 194.6 100.7 55.3 90.8 83.8 146.2 79.2 94.2 96.2 244.0 125.4 105.0 122.7 151.1 107.4 132.3 190.4 59.9 118.1 121.3 101.9 83.9 126.1 149.0 146.1 85.8 77.3 133.2 113.9 55.7 234.4 61.2 131.9 92.1 85.3 169.6 130.7 200.8 223.1 83.5 146.4 118.8 8.8 4.8 8.1 7.3 4.9 9.9 8.5 9.5 11.1 5.8 8.2 11.5 9.3 0.6 8.0 6.4 10.2 8.0 3.8 35.9 37.1 44.6 53.1 36.4 39.3 36.9 39.1 36.5 36.9 38.3 40.7 58.9 25.6 35.3 25.5 62.1 87.1 72.5 36.4 59.7 90.6 36.3 33.1 36.2 31.5 32.7 18.4 41.7 75.4 53.3 15.9 33.2 49.8 22.1 29.7 47.8 55.9 46.0 60.3 50.8 42.0 95.9 56.4 44.4 36.2 38.7 52.5 25.0 25.0 46.7 47.1 48.9 32.8 24.4 34.9 45.4 23.9 43.5 40.4 76.5 33.7 51.9 50.2 41.2 41.7 56.7 39.6 23.9 53.0 74.5 93.5 19.0 32.0 29.7 42.0 269.5 69.0 206.5 223.9 198.3 57.9 92.9 92.8 58.6 49.9 45.4 73.6 UBA3 "hUba3, NAE2, UBE1C" ENSG00000144744 "Ubiquitin like modifier activating enzyme 3" Q8TBC4 3 69054730-69080408 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Ubl conjugation pathway" Ligase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 6 "brain: 383.0" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034873, HPA034874, HPA065335" Supported Approved "Nucleoplasm,Plasma membrane,Centrosome,Cytosol" NA NA 35000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 70: Brain - Nervous system development" "Cluster 44: HDLM-2 - Immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Plasma membrane, Cytosol" "Nucleoplasm, Centrosome" "HPA034873: AB_10670578, HPA034874: AB_2674368, HPA065335: AB_2685473" "unprognostic (2.31e-1)" "unprognostic (1.75e-1)" "unprognostic (5.56e-3)" "unprognostic (9.26e-2)" "unprognostic (9.35e-3)" "unprognostic (5.53e-2)" "prognostic unfavorable (8.57e-4)" "unprognostic (1.08e-1)" "unprognostic (6.18e-2)" "unprognostic (1.60e-3)" "unprognostic (9.40e-2)" "unprognostic (2.71e-2)" "unprognostic (1.39e-3)" "unprognostic (2.61e-3)" "unprognostic (9.24e-2)" "unprognostic (7.80e-3)" "unprognostic (2.52e-1)" 34.3 32.3 83.7 39.4 225.9 39.1 43.4 138.0 136.2 32.1 32.1 34.5 28.8 35.8 41.0 33.9 27.5 29.7 66.6 109.7 198.7 33.9 31.2 32.2 49.6 240.4 162.7 30.0 19.3 45.6 22.9 41.7 245.4 36.6 35.8 62.0 44.9 32.2 41.5 45.0 30.3 39.8 131.0 38.9 26.4 23.7 197.1 44.8 27.1 34.7 49.8 39.4 26.6 383.0 76.6 31.4 75.8 47.1 69.0 90.9 56.1 65.9 74.4 70.4 70.2 39.2 52.2 55.2 18.6 72.5 71.3 42.1 59.1 76.5 80.2 105.0 38.5 77.0 57.7 39.6 53.8 77.1 62.4 72.0 49.8 67.9 54.9 86.7 92.3 45.2 31.9 45.6 94.0 26.8 49.5 49.7 67.5 95.4 26.9 39.6 55.9 53.0 113.2 94.6 32.8 46.2 70.3 51.0 58.4 80.9 34.3 73.3 71.4 53.0 46.9 70.6 93.3 53.2 91.8 67.3 54.5 84.3 69.7 87.9 45.7 71.0 24.3 54.0 28.1 33.6 32.2 30.3 40.1 29.7 29.6 30.5 40.9 39.8 57.1 20.1 40.8 53.0 83.7 225.9 138.0 136.2 109.7 198.7 240.4 162.7 245.4 131.0 197.1 383.0 21.9 35.3 31.4 35.9 35.5 33.8 29.2 66.2 31.9 22.9 21.6 17.9 68.5 14.3 44.5 35.0 39.6 74.5 19.8 15.8 19.6 37.1 15.2 25.1 21.2 26.9 18.6 30.7 44.6 23.6 57.2 28.3 22.4 25.6 42.4 26.0 22.9 17.2 34.1 33.7 62.8 16.3 97.6 37.1 49.6 10.3 40.4 39.6 30.2 44.0 60.6 29.1 24.7 53.3 76.7 31.5 11.7 38.0 28.3 23.7 16.7 36.9 47.3 48.9 26.3 22.2 31.0 34.2 32.1 34.9 42.8 56.8 34.0 24.3 17.5 32.5 UBA6 "FLJ10808, UBE1L2" ENSG00000033178 "Ubiquitin like modifier activating enzyme 6" A0AVT1 4 67612652-67701155 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Ligase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA037001 Approved Enhanced Nucleoplasm,Cytosol NA NA 12000 "Cluster 15: NK-cells - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 1: K-562 - Erythropoiesis" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Cytosol" "HPA037001: AB_10672787" "unprognostic (2.52e-1)" "unprognostic (4.89e-2)" "unprognostic (3.97e-3)" "unprognostic (2.81e-1)" "unprognostic (3.67e-2)" "unprognostic (4.92e-2)" "unprognostic (3.55e-3)" "unprognostic (6.06e-3)" "unprognostic (1.09e-1)" "unprognostic (1.10e-2)" "unprognostic (3.38e-2)" "unprognostic (5.30e-2)" "prognostic unfavorable (7.01e-5)" "unprognostic (2.35e-1)" "unprognostic (1.83e-1)" "unprognostic (4.33e-2)" "unprognostic (4.05e-3)" 6.7 6.6 5.9 9.9 8.0 17.1 8.3 7.5 7.5 10.6 4.9 7.1 8.1 6.8 6.2 11.4 5.7 8.0 5.3 5.6 7.9 6.3 10.7 7.8 12.4 9.7 8.0 7.7 6.2 7.9 12.0 9.8 10.0 7.7 8.4 14.4 6.7 5.5 5.2 8.4 8.6 8.7 8.4 10.2 9.4 10.0 8.7 10.4 7.9 6.5 13.6 10.2 10.6 16.0 34.4 18.8 30.5 24.0 14.8 17.4 20.6 69.5 27.1 31.1 36.2 19.8 45.1 43.4 24.2 28.7 31.8 19.8 31.9 34.6 46.6 50.0 8.9 27.8 30.7 18.7 12.6 49.3 20.4 12.5 10.9 40.3 24.3 21.2 27.8 21.9 67.2 25.0 37.2 13.0 51.5 11.2 18.0 24.3 22.6 30.0 62.6 16.1 25.3 38.3 14.9 18.8 39.2 27.5 13.0 25.3 18.4 13.0 40.6 28.6 31.9 23.6 30.8 17.8 15.0 43.0 50.9 13.5 28.1 6.4 1.8 2.9 2.4 2.3 2.7 3.0 2.8 3.2 2.2 3.0 2.0 2.4 1.3 5.7 2.6 3.1 2.5 1.4 5.9 8.0 7.5 7.5 5.6 7.9 9.7 8.0 10.0 8.4 8.7 16.0 34.6 25.6 21.7 54.5 46.5 70.1 65.2 43.0 37.5 45.8 30.8 17.0 13.5 10.0 34.6 16.5 54.2 29.2 45.0 34.7 3.9 24.6 2.3 28.6 24.8 39.0 32.3 23.8 66.3 17.1 17.8 26.6 39.8 45.3 31.0 62.3 20.0 20.9 23.2 33.7 78.1 27.0 28.5 29.9 54.0 5.8 21.5 31.4 24.9 37.5 34.6 14.6 26.8 77.9 115.7 53.3 36.6 19.9 44.8 87.0 21.2 15.9 34.9 39.9 19.7 28.0 24.0 57.7 43.9 30.9 46.2 58.8 37.6 40.4 22.8 149.0 UBA7 "D8, UBA1B, UBE1L, UBE2" ENSG00000182179 "Ubiquitin like modifier activating enzyme 7" P41226 3 49805209-49813953 "Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Ubl conjugation pathway" Ligase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Gastric mucus-secreting cells: 52.5;granulocytes: 83.0;Proximal enterocytes: 51.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+ SV40 Large T+ RasG12V: 56.7;HEL: 55.7;HMC-1: 103.7" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" "CAB015444, HPA058182" Approved Approved Nucleoplasm,Vesicles,Cytosol NA NA 370000 "Cluster 49: Eosinophils - Unknown function" "Cluster 64: Macrophages - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 51: Myeloid cells - Hemostasis" "Nucleoplasm, Vesicles" Cytosol "CAB015444: AB_793598, HPA058182: AB_2683631" "prognostic favorable (1.55e-4)" "unprognostic (7.07e-3)" "unprognostic (1.59e-2)" "unprognostic (1.61e-2)" "unprognostic (3.77e-1)" "unprognostic (2.31e-2)" "unprognostic (5.08e-3)" "unprognostic (3.61e-2)" "unprognostic (6.33e-2)" "unprognostic (2.00e-1)" "unprognostic (1.40e-1)" "unprognostic (2.17e-1)" "prognostic unfavorable (1.04e-5)" "unprognostic (9.11e-2)" "unprognostic (3.81e-2)" "unprognostic (1.57e-1)" "prognostic favorable (1.48e-4)" 21.6 21.4 10.1 32.7 10.6 40.2 20.7 10.4 12.1 25.6 10.4 29.0 43.4 22.5 15.6 18.7 23.8 27.7 17.9 9.8 10.5 25.6 23.0 35.4 51.2 13.7 11.1 32.8 17.2 2.9 14.1 19.4 12.1 34.8 26.1 1.2 42.3 22.4 9.1 20.5 48.6 20.6 12.3 65.6 27.5 5.8 12.2 39.8 31.8 10.3 33.6 23.1 23.3 13.8 11.6 0.1 0.9 0.3 30.2 31.7 3.5 6.1 27.0 42.7 56.7 0.0 23.9 0.4 4.8 22.4 18.3 6.2 0.1 10.9 3.7 29.9 0.1 55.7 0.6 3.5 22.3 5.3 103.7 49.0 0.7 16.9 1.0 29.6 21.7 2.0 0.1 3.4 10.0 0.3 11.6 13.7 0.1 0.0 1.2 14.6 1.0 1.9 8.8 22.3 0.0 0.9 7.4 10.7 3.8 0.6 1.1 36.8 9.7 8.3 1.1 3.7 2.4 0.1 0.2 0.3 23.2 19.8 2.0 20.7 22.5 38.5 16.4 32.9 14.3 17.1 15.0 14.5 21.3 18.1 13.4 12.4 6.8 17.1 27.6 7.6 15.9 22.0 10.1 10.6 10.4 12.1 9.8 10.5 13.7 11.1 12.1 12.3 12.2 13.8 17.3 32.1 20.3 11.4 28.0 3.8 6.3 10.5 6.8 0.2 9.2 9.1 6.9 17.2 16.6 12.9 0.0 5.2 15.5 28.7 0.0 9.5 6.9 5.8 3.0 13.5 9.5 8.0 0.2 7.8 3.5 11.8 52.5 6.5 83.0 13.2 16.1 7.6 21.6 0.0 0.1 21.7 8.2 20.1 6.4 34.1 11.1 32.5 0.0 15.0 16.8 2.4 19.6 1.0 0.1 5.2 21.7 11.3 14.1 4.4 51.8 5.6 12.8 1.2 6.6 5.8 8.1 0.9 0.3 7.3 4.7 2.9 17.7 6.9 20.2 6.6 UBE2A "HHR6A, HR6A, RAD6A, UBC2" ENSG00000077721 "Ubiquitin conjugating enzyme E2 A" P49459 X 119574536-119591083 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Chromatin regulator, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 508.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003875, HPA051765, HPA065898" Supported "Nucleoplasm,Vesicles,Plasma membrane,Cytosol" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 8: Non-specific - Mitochondria" "Cluster 18: U-2197 - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Plasma membrane" "Vesicles, Cytosol" "HPA003875: AB_2667061, HPA051765: AB_2681597, HPA065898: AB_2685577" "unprognostic (2.27e-3)" "prognostic favorable (2.16e-4)" "unprognostic (1.12e-1)" "unprognostic (9.09e-2)" "unprognostic (1.63e-1)" "prognostic unfavorable (9.07e-4)" "unprognostic (1.66e-3)" "unprognostic (1.96e-2)" "unprognostic (6.54e-2)" "unprognostic (2.96e-2)" "unprognostic (3.49e-2)" "unprognostic (1.33e-1)" "prognostic unfavorable (2.20e-6)" "unprognostic (9.54e-2)" "unprognostic (3.06e-2)" "unprognostic (1.21e-1)" "unprognostic (7.92e-2)" 40.0 27.4 30.1 39.1 30.6 29.8 29.4 34.1 38.8 34.1 27.1 52.3 37.5 32.0 38.2 53.4 27.3 32.6 63.2 29.6 32.2 41.0 30.1 32.9 46.9 34.4 32.5 20.1 29.2 39.2 18.9 56.8 34.4 31.0 45.0 27.1 30.9 33.0 71.9 30.7 39.1 43.0 32.1 26.8 30.5 17.6 32.1 46.1 30.5 55.0 50.4 46.9 32.8 35.1 129.5 104.1 60.8 54.1 103.0 125.6 63.9 122.6 106.3 141.8 130.3 50.8 84.0 96.4 126.4 133.9 240.6 86.4 86.3 65.7 128.6 142.3 60.6 42.7 71.9 47.1 96.6 105.9 72.1 86.9 90.1 134.0 58.3 98.1 99.4 86.5 57.0 83.6 160.1 134.5 166.6 99.9 106.3 125.7 126.9 84.2 64.0 91.6 113.1 76.6 48.9 51.3 171.2 75.0 93.7 73.2 65.8 92.6 101.5 92.4 42.0 184.3 142.5 83.6 147.1 92.4 99.1 136.3 74.6 46.8 58.5 92.5 43.0 92.1 34.8 52.6 37.9 38.5 74.6 48.7 23.7 33.9 78.0 35.0 101.1 58.5 56.8 51.1 30.1 30.6 34.1 38.8 29.6 32.2 34.4 32.5 34.4 32.1 32.1 35.1 67.5 102.5 40.9 12.7 79.1 124.8 91.6 129.4 51.8 17.2 60.7 43.9 66.7 44.3 80.7 40.5 31.3 179.8 93.0 168.6 101.8 95.4 51.7 75.6 55.3 62.9 45.5 70.4 9.9 102.1 176.2 67.7 37.8 63.0 57.0 35.7 46.4 35.5 131.3 8.4 9.4 49.7 103.7 59.1 183.9 15.3 37.0 97.3 83.6 15.9 129.0 49.8 41.2 14.6 18.0 137.6 132.5 40.6 92.2 98.2 85.6 125.2 107.7 35.0 46.0 56.3 101.1 44.1 32.1 74.6 127.9 508.5 94.8 36.6 54.5 120.3 UBE2B "HHR6B, RAD6B, UBC2" ENSG00000119048 "Ubiquitin conjugating enzyme E2 B" P63146 5 134371469-134392108 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 265.8" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 723.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 444.6" "Lineage enriched" "Detected in all" 6 "granulocytes: 444.6" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003875, HPA051765, HPA065898" Supported "Nucleoplasm,Vesicles,Plasma membrane,Cytosol" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Plasma membrane" "Vesicles, Cytosol" "HPA003875: AB_2667061, HPA051765: AB_2681597, HPA065898: AB_2685577" "unprognostic (1.98e-1)" "unprognostic (1.35e-1)" "unprognostic (7.39e-2)" "unprognostic (6.66e-2)" "unprognostic (1.44e-1)" "unprognostic (1.48e-2)" "unprognostic (2.56e-1)" "unprognostic (1.27e-1)" "unprognostic (1.91e-1)" "unprognostic (2.44e-1)" "unprognostic (2.49e-1)" "unprognostic (8.39e-2)" "unprognostic (1.64e-3)" "unprognostic (6.30e-3)" "unprognostic (3.42e-2)" "unprognostic (2.04e-1)" "unprognostic (5.52e-2)" 52.5 74.2 31.5 50.0 33.1 84.4 44.2 36.3 53.2 38.3 30.2 48.0 40.7 53.6 34.8 70.5 37.3 51.0 118.4 34.3 34.8 50.6 56.6 44.9 47.1 29.5 31.0 44.4 53.7 25.8 39.9 48.4 31.0 32.9 42.0 29.2 39.7 23.2 265.8 43.1 46.4 43.3 30.3 43.7 39.6 49.2 32.9 29.3 41.2 99.8 48.1 42.8 43.2 36.7 109.4 27.9 58.2 55.0 50.0 54.1 92.7 80.2 43.5 51.4 60.9 85.6 70.9 58.7 94.1 52.3 138.7 42.7 45.8 60.4 56.0 94.5 47.6 32.1 75.9 92.8 58.2 38.8 63.7 46.5 80.2 47.4 39.3 68.1 44.1 48.8 61.1 103.5 46.8 63.4 62.5 102.1 24.9 32.6 26.7 61.6 63.8 83.8 46.6 82.9 77.6 60.1 62.9 29.3 147.9 62.5 63.0 106.0 87.6 57.8 40.8 78.9 89.4 86.1 129.4 87.0 65.2 72.8 59.4 236.7 58.3 174.0 46.9 68.3 42.9 49.7 58.8 48.1 42.6 47.9 69.9 60.6 444.6 53.0 78.9 48.0 77.5 64.1 31.5 33.1 36.3 53.2 34.3 34.8 29.5 31.0 31.0 30.3 32.9 36.7 187.5 73.7 61.6 40.1 176.5 364.7 321.2 215.1 175.8 77.8 169.9 156.5 315.8 147.3 113.7 75.4 81.3 144.5 182.0 183.1 172.1 173.8 233.2 139.8 102.2 149.7 131.8 261.2 103.0 169.5 123.0 183.3 113.2 167.8 116.8 81.7 115.3 97.4 119.4 87.5 84.2 141.0 181.0 131.5 323.9 315.4 155.0 184.2 227.7 49.6 190.6 150.0 113.3 44.7 68.4 210.6 195.2 113.2 162.5 343.9 153.4 170.7 111.7 91.3 151.2 154.9 262.9 223.5 201.7 145.5 369.7 723.5 192.0 140.4 105.7 488.1 UBE2C UBCH10 ENSG00000175063 "Ubiquitin conjugating enzyme E2 C" O00762 20 45812576-45816957 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 78.5;lymphoid tissue: 113.5" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 129.6;Erythroid cells: 182.1;Extravillous trophoblasts: 449.1;Granulosa cells: 119.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in single" "Immune cell enhanced" "Detected in some" "T-reg: 8.2" "Group enriched" "Detected in many" 5 "granulocytes: 2.1;NK-cells: 2.1;T-cells: 8.2" "Low cell line specificity" "Detected in all" "Group enriched" "Detected in many" 5 "basal ganglia: 4.3;white matter: 11.4" "Low region specificity" "Detected in some" "CAB011464, HPA034569, CAB035990, HPA054975" Approved Approved "Plasma membrane,Cytosol" Yes Yes "Cluster 35: T-regs - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "Plasma membrane, Cytosol" "CAB011464: AB_442965, CAB035990: , HPA034569: AB_2674226, HPA054975: AB_2682658" "unprognostic (1.45e-2)" "unprognostic (2.19e-1)" "unprognostic (1.06e-1)" "unprognostic (2.11e-3)" "unprognostic (2.54e-1)" "unprognostic (1.35e-1)" "prognostic unfavorable (6.24e-6)" "unprognostic (2.27e-3)" "unprognostic (2.59e-2)" "unprognostic (1.04e-1)" "prognostic unfavorable (6.91e-4)" "unprognostic (3.76e-2)" "prognostic unfavorable (0.00e+0)" "unprognostic (3.09e-1)" "unprognostic (3.61e-1)" "unprognostic (4.65e-2)" "unprognostic (2.68e-1)" 2.6 2.9 0.3 21.5 0.3 78.5 4.3 0.9 0.6 6.1 0.7 26.7 21.4 5.7 0.6 37.2 1.9 2.7 1.4 0.2 0.3 1.9 2.9 5.4 45.3 0.3 0.7 1.3 1.0 0.4 0.4 20.4 0.7 1.5 30.9 0.2 5.0 0.9 0.9 18.5 20.6 10.5 0.2 15.8 13.0 16.4 1.6 113.5 1.1 0.2 69.5 6.9 12.3 0.4 312.8 223.9 390.9 188.3 10.4 24.0 225.2 238.5 121.6 390.7 278.4 743.8 345.4 327.6 233.2 115.5 475.6 294.9 2.2 260.5 395.8 141.7 213.7 101.5 168.5 196.0 3.0 145.4 241.6 7.6 27.8 265.7 257.3 57.4 193.4 206.4 1.8 261.6 325.4 516.2 243.5 41.1 237.1 350.8 529.4 256.0 354.8 1.4 134.9 105.9 226.1 188.7 378.3 271.7 154.4 196.2 276.6 209.4 70.1 341.2 298.4 236.2 473.4 84.3 2.9 369.4 208.0 103.4 328.6 0.0 0.0 0.0 0.1 0.0 0.0 0.9 0.8 1.7 0.6 0.1 0.1 0.1 2.1 2.1 0.5 0.3 8.2 3.2 0.3 0.3 0.9 0.6 0.2 0.3 0.3 0.7 0.7 0.2 1.6 0.4 0.9 0.0 3.7 0.0 17.9 17.3 7.8 39.0 5.7 0.0 8.6 14.6 0.0 1.5 9.3 0.0 0.0 129.6 3.6 27.4 0.0 1.3 12.0 5.8 5.9 9.5 1.2 182.1 0.0 0.5 449.1 28.5 25.5 9.6 5.7 119.0 18.2 3.6 92.6 0.0 0.1 41.1 50.8 20.8 18.1 6.4 0.9 24.1 0.0 0.0 1.1 0.0 0.0 0.0 0.0 1.5 7.2 0.0 37.0 12.6 6.2 0.6 1.8 0.0 0.0 0.5 19.2 52.2 50.7 83.2 11.6 31.2 13.7 2.5 68.4 18.4 UBE2D1 "E2(17)KB1, SFT, UBC4/5, UBCH5, UbcH5A" ENSG00000072401 "Ubiquitin conjugating enzyme E2 D1" P51668 10 58334979-58370751 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 138.7;tongue: 65.3" "Cell type enhanced" "Detected in all" "Basal keratinocytes: 194.4;Suprabasal keratinocytes: 190.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 112.3" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003920 Approved Approved "Plasma membrane,Cytosol" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "Plasma membrane, Cytosol" "HPA003920: AB_1858519" "unprognostic (1.12e-1)" "unprognostic (2.08e-1)" "unprognostic (4.23e-3)" "unprognostic (1.76e-1)" "unprognostic (1.52e-2)" "unprognostic (1.21e-2)" "prognostic unfavorable (5.58e-4)" "unprognostic (2.20e-2)" "unprognostic (1.03e-1)" "unprognostic (2.24e-2)" "unprognostic (4.37e-3)" "unprognostic (2.17e-1)" "prognostic unfavorable (8.04e-6)" "unprognostic (9.71e-3)" "unprognostic (4.14e-1)" "unprognostic (1.95e-1)" "unprognostic (5.66e-2)" 13.0 11.8 5.3 16.7 5.7 32.4 7.8 6.6 8.1 8.9 4.4 11.4 7.0 12.6 7.5 11.6 7.1 9.5 33.3 6.1 6.2 8.1 8.3 8.9 13.8 6.6 6.4 8.4 5.5 8.9 3.9 8.9 6.6 9.5 12.0 5.4 5.5 6.7 138.7 5.9 8.3 13.6 6.4 13.4 6.4 4.5 6.3 7.8 8.4 65.3 11.4 15.1 5.6 6.7 19.1 10.2 18.8 24.4 37.5 30.0 12.1 12.4 21.2 13.9 20.3 20.9 16.4 0.0 19.0 18.6 10.3 17.1 36.6 18.0 19.5 19.8 21.2 4.9 3.7 12.2 24.4 15.3 11.8 34.8 19.9 14.4 26.8 18.7 28.1 13.1 10.0 7.8 19.1 6.1 16.5 17.1 23.0 11.7 15.7 13.8 16.9 10.6 21.2 11.2 14.0 18.8 24.2 40.3 20.6 28.5 14.8 10.2 22.8 5.3 18.6 18.2 13.7 19.7 16.4 16.8 16.7 31.3 6.2 10.1 38.5 17.8 6.2 27.1 7.2 8.9 7.3 7.9 20.0 9.8 7.5 6.2 112.3 8.2 23.4 8.3 9.8 23.4 5.3 5.7 6.6 8.1 6.1 6.2 6.6 6.4 6.6 6.4 6.3 6.7 41.6 12.8 11.2 5.5 54.3 194.4 94.1 60.6 46.1 23.7 45.6 45.5 92.4 17.2 39.0 27.6 18.8 29.9 41.7 27.4 76.3 62.3 5.0 32.6 46.9 42.5 41.7 12.0 18.5 42.0 50.4 51.9 38.7 51.2 22.9 19.6 27.5 15.6 73.7 16.8 17.1 40.1 69.2 90.6 104.0 3.0 33.2 147.7 53.4 4.7 94.6 17.9 22.6 12.5 21.2 81.2 52.7 32.4 26.4 108.4 16.1 54.3 33.6 16.1 6.6 51.4 59.1 33.5 19.9 47.1 190.2 149.0 42.8 14.9 28.5 118.2 UBE2D2 "UBC4, UbcH5B" ENSG00000131508 "Ubiquitin conjugating enzyme E2 D2" P62837 5 139526431-139628434 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003920 Approved Approved "Plasma membrane,Cytosol" NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 23: Testis - Cell cycle regulation" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 44: Endometrium - Transcription" "Plasma membrane, Cytosol" "HPA003920: AB_1858519" "unprognostic (1.14e-1)" "unprognostic (2.75e-3)" "prognostic favorable (5.09e-5)" "prognostic favorable (5.90e-4)" "unprognostic (2.33e-1)" "unprognostic (8.19e-3)" "prognostic unfavorable (9.63e-7)" "unprognostic (7.41e-3)" "unprognostic (2.17e-1)" "unprognostic (1.21e-1)" "unprognostic (9.33e-2)" "unprognostic (1.41e-3)" "prognostic unfavorable (2.09e-5)" "unprognostic (8.00e-2)" "unprognostic (1.01e-1)" "unprognostic (4.20e-1)" "unprognostic (1.07e-1)" 78.4 59.9 75.8 66.9 82.0 106.9 72.6 79.3 84.2 84.2 63.0 106.8 46.5 72.8 102.6 89.0 95.0 49.8 93.7 77.9 85.8 80.1 82.6 77.0 83.5 78.7 80.4 64.3 66.5 72.8 62.3 65.5 80.0 57.0 92.8 77.2 61.0 72.3 190.3 77.9 70.4 74.3 81.9 79.3 70.2 135.6 80.1 128.0 61.3 127.3 140.2 79.7 72.8 86.4 175.9 113.9 194.3 137.0 127.9 161.7 125.4 179.6 165.5 204.7 238.6 292.0 160.6 247.8 229.1 185.7 254.0 108.8 192.6 300.2 272.5 162.4 113.7 140.1 115.0 172.1 249.9 136.9 119.7 129.9 152.0 204.9 301.8 177.4 221.8 159.5 125.0 203.1 192.9 175.5 215.3 197.2 108.1 60.4 124.0 162.7 198.1 179.6 220.4 202.0 177.5 117.0 157.1 198.7 309.4 413.4 125.2 121.6 148.9 156.4 87.6 132.5 223.5 146.0 260.0 343.8 112.3 223.2 128.0 44.1 57.0 115.9 57.7 53.7 62.1 89.2 82.1 80.9 63.3 90.7 102.5 90.3 90.7 65.1 66.2 106.1 110.8 58.0 75.8 82.0 79.3 84.2 77.9 85.8 78.7 80.4 80.0 81.9 80.1 86.4 137.1 32.1 69.8 35.9 215.4 171.8 182.3 204.8 112.7 76.3 124.8 146.9 96.4 124.4 96.5 68.0 81.3 181.4 205.8 158.0 215.2 208.4 637.0 457.2 94.2 131.0 123.4 148.8 62.0 178.4 228.0 104.8 77.5 230.9 138.8 119.4 109.9 80.6 178.0 94.2 54.4 120.8 142.4 136.4 203.4 550.0 104.4 150.8 152.9 49.6 189.5 170.7 234.8 38.2 65.7 228.7 127.1 93.6 237.3 234.8 123.8 200.9 63.9 105.1 118.3 102.2 171.2 459.7 152.5 149.4 203.7 249.6 217.1 111.7 160.4 247.1 UBE2D3 UbcH5C ENSG00000109332 "Ubiquitin conjugating enzyme E2 D3" P61077 4 102794383-102868896 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003920 Uncertain Approved "Plasma membrane,Cytosol" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 10: Non-specific - Unknown function" "Plasma membrane, Cytosol" "HPA003920: AB_1858519" "unprognostic (7.43e-2)" "unprognostic (3.19e-1)" "unprognostic (1.27e-2)" "unprognostic (5.78e-2)" "unprognostic (6.44e-2)" "unprognostic (4.96e-2)" "unprognostic (1.17e-1)" "unprognostic (8.44e-3)" "unprognostic (1.14e-1)" "unprognostic (1.95e-1)" "unprognostic (5.75e-2)" "unprognostic (3.31e-2)" "prognostic favorable (4.51e-4)" "unprognostic (5.08e-2)" "unprognostic (2.79e-1)" "unprognostic (4.54e-2)" "unprognostic (1.34e-2)" 182.7 171.7 85.7 172.0 92.6 478.3 141.9 101.1 120.6 127.1 93.4 154.9 154.0 125.3 113.8 173.4 125.9 142.5 149.4 92.1 103.9 172.2 251.4 175.3 189.6 102.5 96.0 131.5 154.2 133.5 98.4 159.0 99.8 106.8 144.4 129.0 116.7 102.1 243.6 136.4 158.3 129.9 101.4 149.5 144.4 127.0 95.6 198.5 159.2 197.9 197.0 185.6 128.0 113.7 301.6 169.1 275.4 223.4 286.2 408.0 235.9 301.2 395.1 260.1 243.6 257.4 416.4 319.3 190.6 304.4 336.8 168.6 294.7 400.8 352.5 299.6 149.8 292.0 165.8 209.6 300.3 415.5 240.4 314.0 247.9 288.6 398.9 334.3 343.4 258.7 372.9 316.4 350.9 243.1 613.4 235.1 200.2 341.0 167.1 318.4 269.9 231.5 261.5 283.7 275.6 232.1 183.5 464.8 349.6 318.2 193.0 241.0 318.4 270.0 231.1 179.2 276.3 277.9 389.8 491.3 288.2 227.2 297.0 614.9 253.7 394.0 163.5 256.0 216.3 165.9 203.4 194.4 217.6 139.2 205.8 190.5 817.2 215.7 271.9 149.8 229.6 422.1 85.7 92.6 101.1 120.6 92.1 103.9 102.5 96.0 99.8 101.4 95.6 113.7 303.4 166.7 193.1 98.9 291.7 844.0 693.9 408.2 233.9 133.7 251.5 166.9 229.8 193.0 242.3 139.8 125.1 311.5 317.4 336.1 547.8 361.0 779.4 257.1 246.7 344.0 240.8 348.7 159.7 382.2 561.6 286.0 202.3 371.3 224.9 154.8 193.1 235.7 392.9 122.8 145.8 283.8 303.2 403.0 825.6 635.1 164.7 415.1 357.5 111.5 399.4 160.0 280.2 104.5 185.0 454.4 347.2 149.0 296.4 612.3 335.8 428.8 242.4 170.6 105.2 270.6 531.9 217.2 180.7 258.2 813.3 638.4 382.5 172.3 268.2 784.3 UBE2D4 HBUCE1 ENSG00000078967 "Ubiquitin conjugating enzyme E2 D4 (putative)" Q9Y2X8 7 43926436-43956136 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 32.5" "Cell type enhanced" "Detected in many" "Distal tubular cells: 54.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SH-SY5Y: 30.2" "Low region specificity" "Detected in all" HPA003920 Approved Approved "Plasma membrane,Cytosol" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 80: Striated muscle - Unknown function" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 7: Non-specific - Mitochondria" "Plasma membrane, Cytosol" "HPA003920: AB_1858519" "unprognostic (9.95e-3)" "unprognostic (6.76e-2)" "unprognostic (6.87e-2)" "unprognostic (8.94e-2)" "unprognostic (8.24e-2)" "unprognostic (5.24e-2)" "unprognostic (2.42e-1)" "unprognostic (3.58e-3)" "unprognostic (4.74e-2)" "unprognostic (5.04e-2)" "prognostic favorable (4.86e-4)" "prognostic favorable (5.77e-4)" "prognostic favorable (6.51e-4)" "unprognostic (1.11e-1)" "unprognostic (8.74e-3)" "unprognostic (1.89e-1)" "unprognostic (1.34e-1)" 5.8 8.3 11.7 2.4 12.2 2.2 5.0 14.2 17.6 4.6 9.8 6.5 2.4 4.5 5.7 5.2 4.5 3.4 10.9 12.3 11.2 6.9 10.7 4.4 2.7 12.0 11.7 5.1 10.0 4.6 5.1 2.8 11.9 5.7 2.9 6.9 5.6 4.4 32.5 4.9 3.9 4.4 11.8 4.7 4.6 3.0 11.5 2.7 4.9 27.8 2.7 5.3 5.2 12.7 4.9 4.0 2.4 11.0 11.0 4.5 1.8 2.3 5.8 2.9 3.7 2.1 5.6 4.6 6.3 6.3 8.1 5.3 3.1 2.5 4.4 10.5 5.4 5.0 5.8 5.4 4.1 10.9 9.8 3.4 5.2 3.3 5.0 4.2 3.6 5.5 5.6 9.2 4.0 3.0 6.5 6.1 5.4 5.9 5.1 4.0 3.3 7.1 6.2 5.9 8.8 30.2 5.0 9.7 3.8 4.4 4.9 3.3 3.2 1.9 6.0 4.1 6.9 13.5 10.8 2.2 5.7 14.2 10.9 10.2 14.5 17.5 11.1 23.8 11.4 12.8 13.5 12.5 15.1 12.7 16.2 13.4 1.4 9.9 28.7 13.0 12.6 8.8 11.7 12.2 14.2 17.6 12.3 11.2 12.0 11.7 11.9 11.8 11.5 12.7 14.9 0.0 6.5 8.8 10.4 6.2 9.1 9.4 4.0 9.6 24.3 24.3 24.6 14.3 10.0 16.5 2.1 11.9 11.9 8.4 54.8 18.7 6.2 8.9 7.2 12.9 18.7 9.9 14.2 28.4 20.3 14.9 8.2 8.7 4.5 11.1 12.5 25.4 27.4 11.8 13.5 8.0 8.2 11.6 14.1 10.7 12.2 12.5 16.0 8.4 18.4 18.8 5.2 20.1 12.1 14.1 7.6 21.8 11.2 12.1 15.5 52.0 5.5 11.6 6.6 23.0 10.5 15.6 9.6 10.8 11.2 7.7 8.8 16.5 8.4 12.3 UBE2E1 UbcH6 ENSG00000170142 "Ubiquitin conjugating enzyme E2 E1" P51965 3 23805955-23891640 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030445, CAB073413" Approved Approved Nucleoplasm NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 25: RPMI-8226 - Immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Nucleoplasm "CAB073413: , HPA030445: AB_10669599" "unprognostic (7.50e-2)" "unprognostic (2.78e-2)" "unprognostic (7.91e-3)" "unprognostic (7.13e-2)" "unprognostic (6.74e-3)" "unprognostic (1.74e-1)" "prognostic unfavorable (9.97e-7)" "unprognostic (3.69e-2)" "unprognostic (3.53e-2)" "unprognostic (1.34e-2)" "unprognostic (5.36e-3)" "unprognostic (2.70e-2)" "unprognostic (2.40e-2)" "unprognostic (1.94e-1)" "unprognostic (2.94e-1)" "unprognostic (2.75e-1)" "unprognostic (1.93e-1)" 68.6 54.9 84.5 67.1 91.0 123.2 89.5 91.5 121.1 74.7 83.9 76.9 50.6 66.6 68.3 80.9 63.5 61.8 62.6 82.4 94.1 69.3 71.2 71.2 102.4 92.5 88.7 79.3 53.9 103.7 34.4 96.1 93.8 71.3 79.0 73.1 64.6 73.6 89.4 63.8 51.4 77.5 93.2 73.8 60.9 51.7 87.2 98.5 61.4 94.9 108.1 92.5 65.1 101.8 199.3 101.7 202.1 99.1 129.2 170.3 151.5 141.0 256.8 172.7 234.0 80.1 235.8 182.6 121.2 166.3 146.8 65.6 232.5 208.6 228.2 202.2 201.4 235.5 75.8 97.3 177.0 260.2 138.8 172.6 162.8 230.4 324.9 207.1 278.6 118.9 177.2 210.8 136.0 86.7 188.6 235.8 268.0 117.8 255.3 201.6 80.7 531.0 262.0 129.3 54.3 176.0 146.7 131.5 215.5 202.5 146.4 329.1 183.1 132.2 144.2 85.9 109.5 154.9 99.8 363.6 152.2 231.9 110.9 1.7 4.2 3.7 1.8 4.7 2.9 3.0 2.4 1.8 3.8 2.8 3.2 2.0 1.5 4.3 2.8 4.0 2.0 2.1 84.5 91.0 91.5 121.1 82.4 94.1 92.5 88.7 93.8 93.2 87.2 101.8 30.7 44.8 28.9 66.3 52.7 72.3 62.6 89.0 59.2 31.3 37.9 24.9 68.2 31.5 59.5 18.4 4.2 97.3 27.9 56.7 56.7 90.4 25.6 37.0 28.7 58.4 46.3 41.0 47.1 78.0 99.4 43.2 25.5 32.7 40.6 40.2 43.5 22.5 98.8 20.2 50.6 37.9 150.5 69.4 156.5 55.3 40.7 61.5 97.8 127.4 98.9 81.6 36.0 90.5 102.8 71.8 61.9 48.5 40.8 78.0 21.5 43.4 60.1 27.7 52.6 47.1 63.0 35.4 59.5 61.7 90.2 72.1 35.7 27.6 52.2 72.6 UBE2E2 "FLJ25157, UbcH8" ENSG00000182247 "Ubiquitin conjugating enzyme E2 E2" Q96LR5 3 23203020-23591794 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 652.7;Inhibitory neurons: 399.4;Microglial cells: 402.8;Oligodendrocyte precursor cells: 513.2;Oligodendrocytes: 845.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 6 "classical monocyte: 41.7;intermediate monocyte: 50.3;memory B-cell: 35.1;myeloid DC: 57.6;naive B-cell: 40.1;non-classical monocyte: 54.4;plasmacytoid DC: 74.0" "Group enriched" "Detected in all" 6 "B-cells: 40.1;dendritic cells: 74.0;monocytes: 54.4" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003303, HPA028872, HPA030445, CAB073417" Approved Approved Nucleoplasm No No "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 68: Epididymis - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "CAB073417: , HPA003303: AB_1858521, HPA028872: AB_10966277, HPA030445: AB_10669599" "unprognostic (2.20e-1)" "unprognostic (2.30e-1)" "unprognostic (1.52e-2)" "unprognostic (3.68e-3)" "unprognostic (3.74e-2)" "unprognostic (1.70e-1)" "unprognostic (9.19e-3)" "unprognostic (3.11e-3)" "unprognostic (1.32e-1)" "unprognostic (1.20e-1)" "unprognostic (4.20e-1)" "unprognostic (4.59e-2)" "unprognostic (1.60e-1)" "unprognostic (1.44e-2)" "unprognostic (2.68e-2)" "unprognostic (3.11e-2)" "unprognostic (6.11e-3)" 23.9 8.9 14.3 10.6 17.2 7.0 18.3 14.5 28.1 22.9 9.4 18.2 4.6 18.2 25.7 17.4 13.7 15.4 19.9 20.2 16.8 17.1 13.4 17.8 16.4 13.2 12.8 16.2 7.0 13.5 12.0 7.4 14.4 14.7 4.8 16.6 11.9 13.3 16.0 16.8 8.3 18.9 12.6 14.3 11.6 15.1 13.7 18.1 13.9 12.4 12.6 16.2 17.8 28.4 36.7 12.9 33.3 0.6 29.0 32.1 30.3 22.6 38.2 20.8 29.0 3.6 29.2 31.7 15.1 19.9 28.5 3.5 24.5 35.2 26.5 0.2 24.6 0.0 15.3 4.3 20.8 0.0 24.5 25.6 36.2 30.0 50.0 21.1 20.2 24.5 1.9 32.4 19.0 5.9 16.8 7.2 23.7 20.7 18.6 34.9 13.0 36.8 20.4 0.8 8.5 17.7 24.8 14.4 0.4 23.8 30.7 20.9 17.8 20.4 29.1 13.8 25.7 31.2 10.9 49.4 19.2 14.2 5.8 0.1 41.7 0.2 0.7 50.3 0.9 35.1 1.4 0.6 57.6 40.1 9.1 3.5 1.1 2.5 54.4 74.0 0.7 15.7 14.3 17.2 14.5 28.1 20.2 16.8 13.2 12.8 14.4 12.6 13.7 28.4 13.3 22.4 9.8 159.3 48.4 25.6 12.2 77.2 34.7 24.0 31.3 27.1 38.2 15.7 28.1 31.3 16.7 34.8 24.2 0.9 68.4 12.0 24.2 9.6 30.8 24.6 1.8 8.2 652.7 29.2 43.1 42.1 5.6 18.8 0.0 38.5 14.6 41.4 47.7 32.0 399.4 1.1 67.1 47.3 73.9 16.0 39.4 49.2 78.2 402.8 40.5 14.8 1.0 513.2 845.2 13.9 1.2 53.0 32.8 64.6 0.0 152.7 17.3 3.6 32.9 14.9 67.3 36.3 91.0 44.1 42.3 38.6 4.6 15.1 0.7 8.6 UBE2E3 UbcH9 ENSG00000170035 "Ubiquitin conjugating enzyme E2 E3" Q969T4 2 180967248-181076585 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Growth regulation, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "AF22: 654.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003303, HPA030445" Approved NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 80: Striated muscle - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 10: Non-specific - Unknown function" "HPA003303: AB_1858521, HPA030445: AB_10669599" "unprognostic (8.85e-2)" "unprognostic (1.77e-1)" "unprognostic (1.51e-1)" "unprognostic (2.96e-2)" "unprognostic (2.23e-1)" "prognostic unfavorable (8.08e-5)" "prognostic unfavorable (9.11e-4)" "unprognostic (1.00e-3)" "unprognostic (4.99e-2)" "unprognostic (8.46e-2)" "prognostic unfavorable (1.78e-5)" "unprognostic (8.75e-2)" "unprognostic (3.86e-1)" "unprognostic (2.50e-1)" "unprognostic (1.28e-1)" "unprognostic (2.18e-1)" "unprognostic (4.40e-1)" 61.6 45.8 57.8 40.1 60.8 48.3 58.1 59.9 71.5 56.2 51.4 51.4 46.7 51.6 55.8 46.7 58.3 71.4 54.2 74.3 59.7 71.8 58.3 39.9 39.6 56.6 57.8 52.5 56.5 79.4 35.3 48.6 58.0 40.0 54.4 68.4 54.6 39.6 175.1 57.0 42.5 42.9 62.3 40.3 59.2 56.8 58.8 67.9 73.7 88.6 48.4 61.6 46.9 64.1 104.8 46.6 654.4 22.8 189.8 243.1 104.0 137.1 171.9 112.8 139.2 51.0 124.0 51.4 117.1 188.5 94.5 43.8 400.7 140.5 202.1 125.9 120.3 177.2 59.0 142.5 91.6 83.5 81.3 96.7 127.9 99.3 94.8 114.6 150.9 105.4 91.9 93.3 280.7 57.5 152.6 77.7 125.6 71.2 217.6 147.0 66.8 122.1 193.2 91.1 113.4 126.3 59.7 62.8 58.1 178.3 33.7 121.5 140.1 218.2 143.2 129.4 162.0 81.1 55.0 143.7 215.7 32.6 124.3 29.1 28.2 53.7 17.6 25.4 21.3 15.0 13.6 22.7 18.4 9.5 14.3 15.7 25.6 18.5 36.3 60.0 5.9 20.5 57.8 60.8 59.9 71.5 74.3 59.7 56.6 57.8 58.0 62.3 58.8 64.1 69.3 9.6 24.2 100.9 50.3 102.9 83.7 111.2 70.6 151.8 84.4 74.4 37.7 108.7 63.7 55.2 29.2 31.9 84.8 56.4 229.0 95.8 36.9 54.3 51.6 59.8 59.8 108.8 115.4 101.9 83.4 81.2 60.6 57.8 23.5 61.8 72.1 55.9 85.3 75.7 67.7 39.4 91.6 71.4 63.9 79.7 62.7 76.3 129.9 71.2 62.4 103.9 79.3 160.9 158.3 113.7 41.6 36.1 87.7 74.8 58.9 172.6 51.8 73.3 26.3 56.4 81.7 83.1 191.6 77.3 122.3 36.0 55.4 57.9 50.9 103.4 UBE2F NCE2 ENSG00000184182 "Ubiquitin conjugating enzyme E2 F (putative)" Q969M7 2 237966827-238042782 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 282.2;monocytes: 215.5;NK-cells: 193.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" HPA037444 Approved Approved Cytosol NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 39: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 38: Extravillous trophoblasts - Unknown function" Cytosol "HPA037444: AB_10672491" "unprognostic (1.73e-1)" "unprognostic (1.65e-1)" "unprognostic (3.80e-2)" "unprognostic (6.92e-3)" "unprognostic (3.39e-1)" "unprognostic (1.56e-1)" "prognostic unfavorable (2.72e-4)" "unprognostic (3.43e-3)" "unprognostic (6.64e-2)" "unprognostic (3.87e-1)" "unprognostic (1.69e-2)" "unprognostic (2.04e-1)" "prognostic unfavorable (1.59e-7)" "unprognostic (2.04e-2)" "unprognostic (6.39e-2)" "unprognostic (3.60e-2)" "unprognostic (2.51e-1)" 26.7 29.7 33.0 25.5 33.7 41.8 22.8 35.9 40.6 27.7 32.5 29.6 24.7 23.1 53.0 43.1 18.8 28.7 56.7 33.4 38.0 28.2 44.2 22.6 32.1 37.5 37.7 12.6 70.5 41.8 21.0 39.9 38.7 25.4 33.7 16.0 25.2 30.3 60.7 18.8 26.9 35.6 35.5 23.7 26.5 26.0 36.1 34.5 35.4 69.1 33.1 40.7 23.5 38.3 42.9 23.9 53.6 55.1 69.2 83.0 74.8 38.9 55.5 43.3 44.4 26.0 26.4 22.0 13.7 88.7 93.7 35.1 62.3 84.9 67.9 33.7 22.7 31.6 28.5 86.6 86.2 13.1 70.1 48.1 137.7 57.9 87.1 40.1 78.1 100.8 94.2 13.7 80.1 64.0 35.1 55.9 59.8 60.9 33.8 41.8 35.0 39.1 66.3 17.8 36.0 53.0 45.2 36.2 77.0 89.4 31.0 52.8 49.7 47.6 41.7 54.9 43.1 17.1 14.3 43.6 57.1 38.4 35.8 112.4 50.0 63.8 66.3 68.2 26.2 26.2 44.8 40.4 45.0 25.4 40.7 41.4 37.3 102.3 78.5 56.4 51.6 63.6 33.0 33.7 35.9 40.6 33.4 38.0 37.5 37.7 38.7 35.5 36.1 38.3 17.6 6.4 18.4 0.0 26.4 32.5 24.1 33.0 11.4 24.2 37.7 24.9 48.1 30.0 21.6 27.6 8.4 84.9 87.3 38.6 56.7 49.7 23.6 15.0 23.9 27.1 41.8 102.5 0.0 79.4 282.2 24.9 15.8 13.8 21.5 13.1 22.1 41.7 152.7 26.9 0.0 58.1 32.6 72.2 105.7 61.3 25.7 67.6 35.6 0.0 215.5 28.3 193.6 0.0 0.0 71.8 31.9 30.9 25.7 46.0 49.7 62.2 23.4 21.7 39.5 14.8 31.4 123.5 79.4 19.0 40.3 65.7 36.2 16.0 35.5 34.6 UBE2G1 "UBC7, UBE2G" ENSG00000132388 "Ubiquitin conjugating enzyme E2 G1" P62253 17 4269259-4366628 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 210.2" "Cell type enhanced" "Detected in all" "Basal keratinocytes: 286.0;Late spermatids: 248.3;Suprabasal keratinocytes: 239.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045681, HPA050551" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 13: T-cells - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 28: Keratinocytes - Keratinization" "Nucleoplasm, Cytosol" "HPA045681: AB_2679417, HPA050551: AB_2681171" "unprognostic (1.57e-3)" "unprognostic (1.94e-1)" "unprognostic (2.34e-2)" "unprognostic (1.80e-2)" "unprognostic (5.16e-2)" "unprognostic (5.84e-2)" "unprognostic (1.87e-1)" "unprognostic (2.64e-2)" "unprognostic (5.13e-2)" "unprognostic (1.86e-1)" "unprognostic (2.80e-1)" "unprognostic (1.67e-2)" "unprognostic (9.99e-2)" "unprognostic (2.16e-1)" "unprognostic (4.58e-2)" "unprognostic (3.97e-2)" "unprognostic (6.50e-2)" 21.0 19.1 15.8 25.4 21.4 31.5 20.1 21.0 24.3 25.2 11.6 39.7 22.5 22.7 14.7 52.2 16.3 16.0 37.9 16.1 18.7 27.0 30.3 15.6 38.8 21.5 19.2 15.6 18.4 21.5 9.7 18.9 21.7 22.6 24.2 17.5 21.0 20.8 210.2 28.0 23.6 27.2 20.3 20.7 21.8 23.2 21.0 24.9 16.1 84.1 46.4 24.5 32.1 26.5 54.5 57.8 52.7 38.9 42.2 44.3 74.9 51.7 41.4 48.2 42.1 40.0 27.0 84.5 52.8 51.2 39.4 57.2 66.3 48.1 77.2 44.8 53.9 31.7 28.6 45.9 41.3 46.5 57.4 38.0 70.3 45.8 66.1 33.8 65.6 55.8 56.5 88.9 40.1 24.3 59.4 42.5 58.2 40.1 29.6 76.1 27.9 78.1 56.4 35.1 22.7 42.3 48.9 41.8 41.6 77.4 41.1 29.9 49.6 48.1 36.8 57.0 58.7 34.3 43.8 118.9 36.9 42.8 37.7 13.3 15.8 39.0 22.2 16.8 29.9 34.1 28.3 29.1 20.2 24.4 28.3 28.9 28.1 32.5 18.6 14.8 28.9 21.8 15.8 21.4 21.0 24.3 16.1 18.7 21.5 19.2 21.7 20.3 21.0 26.5 28.3 22.4 14.4 31.3 70.6 286.0 36.5 47.8 111.5 18.8 47.0 31.0 67.6 27.1 32.2 25.8 6.2 47.0 47.8 41.4 82.2 30.9 139.5 36.7 25.7 35.5 38.4 26.5 47.9 26.7 59.6 31.1 32.6 39.9 21.0 13.9 31.1 62.3 48.1 15.2 46.3 38.3 44.7 36.5 81.1 248.3 19.6 35.7 67.6 30.9 43.1 28.7 36.0 36.2 84.4 43.0 30.4 21.1 154.3 65.7 40.4 75.6 35.4 17.1 6.6 25.9 43.5 70.8 50.8 85.3 239.7 66.8 58.2 13.8 30.1 54.0 UBE2G2 UBC7 ENSG00000184787 "Ubiquitin conjugating enzyme E2 G2" P60604 21 44768580-44801826 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 211.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003332 Approved NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 16: U-266 - Nucleosome" "Cluster 31: Spermatids - Spermatogenesis" "HPA003332: AB_1858525" "unprognostic (7.58e-2)" "unprognostic (5.41e-2)" "unprognostic (1.58e-2)" "unprognostic (4.45e-2)" "unprognostic (6.30e-2)" "unprognostic (4.67e-2)" "unprognostic (5.99e-2)" "unprognostic (3.79e-3)" "unprognostic (6.93e-3)" "unprognostic (7.02e-2)" "unprognostic (1.40e-2)" "unprognostic (6.98e-3)" "prognostic unfavorable (7.02e-5)" "unprognostic (1.79e-1)" "unprognostic (1.69e-1)" "unprognostic (2.75e-2)" "unprognostic (3.55e-2)" 26.7 20.9 21.1 13.4 22.8 25.9 17.5 21.9 24.7 13.5 20.0 22.2 13.3 20.2 8.4 16.1 16.3 12.1 34.7 21.3 21.8 24.4 27.6 16.9 16.2 22.4 22.3 13.7 26.7 20.5 8.2 14.2 22.6 14.8 14.1 20.7 12.6 21.3 61.3 15.3 16.6 20.4 22.1 19.7 21.6 12.2 22.0 22.9 16.9 51.8 14.9 21.2 12.5 24.2 51.9 11.5 34.9 44.3 46.2 20.6 31.3 37.0 27.5 29.5 31.7 40.5 6.7 66.4 33.4 35.8 38.6 20.5 49.4 43.5 27.2 61.9 51.1 107.3 7.0 33.6 35.5 79.2 19.4 33.3 50.0 39.5 39.5 14.7 47.0 71.3 99.8 47.9 43.0 24.6 89.2 13.3 86.7 35.4 44.2 73.2 31.1 61.2 41.4 28.3 39.3 72.5 49.6 18.2 52.3 30.5 17.6 68.5 37.3 31.1 21.2 28.5 58.5 73.8 144.7 64.1 29.3 96.1 36.3 3.2 16.1 8.5 20.8 16.8 22.8 16.0 19.0 21.5 17.3 16.2 20.1 21.3 4.9 20.8 20.1 24.6 21.1 17.4 21.1 22.8 21.9 24.7 21.3 21.8 22.4 22.3 22.6 22.1 22.0 24.2 54.6 57.7 115.4 70.8 48.3 47.7 38.4 32.0 39.3 58.8 37.3 34.0 70.6 28.6 48.4 53.3 66.7 40.7 53.3 29.8 25.4 32.9 63.4 36.8 68.5 54.1 30.0 37.4 56.3 40.7 26.3 41.3 26.0 49.7 43.6 66.6 37.1 69.7 35.3 32.0 57.5 31.2 26.4 42.2 37.4 211.1 41.3 42.9 28.4 32.8 43.2 39.5 49.4 73.9 56.7 43.2 21.5 50.4 53.6 55.6 27.4 36.7 43.0 102.2 26.3 59.3 42.8 42.9 49.4 44.9 56.0 35.8 49.4 75.6 46.0 40.9 UBE2H "GID3, UBC8, UBCH" ENSG00000186591 "Ubiquitin conjugating enzyme E2 H" P62256 7 129830732-129952960 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Glandular and luminal cells: 365.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003302 Approved Approved Mitochondria NA NA 21000 "Cluster 24: B-cells - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 44: Endometrium - Transcription" Mitochondria "HPA003302: AB_1858526" "unprognostic (1.15e-1)" "unprognostic (5.85e-2)" "unprognostic (5.67e-3)" "unprognostic (2.76e-1)" "unprognostic (2.25e-1)" "unprognostic (3.08e-2)" "unprognostic (1.13e-1)" "unprognostic (1.37e-1)" "unprognostic (9.43e-2)" "unprognostic (6.19e-2)" "prognostic unfavorable (2.33e-5)" "unprognostic (1.13e-1)" "unprognostic (3.73e-2)" "unprognostic (2.37e-1)" "unprognostic (1.12e-1)" "unprognostic (3.58e-1)" "unprognostic (1.23e-1)" 46.8 64.7 43.0 29.1 44.2 42.3 34.4 46.4 49.1 44.7 58.7 42.3 23.4 44.3 37.6 49.9 44.6 44.6 98.2 42.1 45.4 42.1 44.2 38.8 31.8 48.7 43.4 41.7 84.3 49.2 29.4 52.5 45.0 36.1 26.0 42.0 39.3 41.5 69.3 31.2 24.4 49.2 41.8 28.6 34.6 36.4 45.8 37.4 45.0 60.6 39.8 40.1 33.7 47.8 82.6 43.8 58.5 56.1 126.1 107.5 86.5 72.0 97.8 45.8 51.1 22.9 92.5 34.0 87.4 76.6 123.8 62.5 46.2 81.6 59.5 40.9 22.6 11.5 63.5 28.6 98.3 23.6 36.8 146.7 106.9 61.3 99.7 106.3 89.7 36.3 27.5 104.1 71.5 29.9 31.1 26.1 80.0 60.5 49.8 24.4 27.8 77.2 95.9 106.5 20.3 59.6 68.3 164.7 43.8 166.0 17.1 27.2 89.1 51.7 24.2 72.2 76.5 83.5 65.6 58.5 102.1 28.9 49.7 2.2 1.4 3.4 2.8 1.2 3.8 2.3 2.8 2.6 1.3 4.5 3.6 3.8 4.8 0.9 1.5 2.3 4.4 1.3 43.0 44.2 46.4 49.1 42.1 45.4 48.7 43.4 45.0 41.8 45.8 47.8 69.9 41.7 51.8 87.1 43.1 145.8 187.5 65.7 59.7 65.1 83.7 49.4 102.9 44.3 69.3 71.7 60.5 116.3 56.7 38.6 41.1 66.0 93.5 225.7 91.2 81.4 59.1 100.0 97.1 70.9 67.1 65.2 43.8 365.8 14.7 53.9 45.3 73.1 41.8 43.7 116.9 35.3 54.9 40.3 69.8 44.0 44.1 52.0 48.0 89.0 26.2 87.4 51.5 113.1 108.5 118.3 33.6 78.6 60.5 227.6 27.6 49.7 95.3 35.6 13.1 65.9 69.0 46.5 22.5 78.6 153.7 200.4 49.2 79.7 26.6 274.3 UBE2I UBC9 ENSG00000103275 "Ubiquitin conjugating enzyme E2 I" P63279 16 1308880-1327018 "Cancer-related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters" "Cell cycle, Cell division, Chromosome partition, Host-virus interaction, Mitosis, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003909, CAB009021, CAB079920" Approved Supported Nucleoplasm,Nucleoli NA NA 130000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 34: Non-specific - Transcription" "Cluster 14: REH - Unknown function" "Cluster 10: Non-specific - Unknown function" Nucleoplasm Nucleoli "CAB009021: AB_2210610, CAB079920: AB_2809487, HPA003909: AB_1858529" "unprognostic (2.12e-1)" "unprognostic (1.01e-2)" "unprognostic (1.55e-2)" "unprognostic (3.51e-1)" "unprognostic (1.21e-1)" "unprognostic (1.52e-1)" "prognostic unfavorable (7.50e-4)" "unprognostic (2.88e-3)" "unprognostic (1.20e-1)" "unprognostic (1.89e-2)" "unprognostic (7.60e-3)" "unprognostic (3.56e-1)" "unprognostic (7.28e-2)" "unprognostic (9.30e-2)" "unprognostic (1.57e-1)" "prognostic favorable (5.68e-4)" "unprognostic (1.15e-3)" 62.5 76.3 42.5 60.3 44.0 81.6 62.0 46.1 49.3 64.7 37.1 63.8 45.1 72.7 48.7 74.2 67.3 34.3 68.2 45.2 45.2 63.4 40.8 53.1 76.0 39.3 42.3 93.1 49.1 72.0 61.6 58.1 40.2 53.4 47.3 31.7 56.4 46.7 58.0 68.0 61.1 53.8 42.2 71.9 52.9 47.6 47.1 110.3 53.2 57.0 89.3 66.6 63.1 42.1 121.3 161.1 269.0 157.7 112.7 135.8 114.4 170.0 121.7 154.3 152.9 191.8 190.1 208.2 137.7 148.1 140.7 142.4 193.2 159.2 197.9 151.2 133.4 130.6 136.6 188.4 178.6 194.9 148.0 127.1 100.7 152.1 180.0 149.0 170.0 169.9 190.3 124.3 148.0 254.4 349.6 193.0 219.0 136.0 118.5 434.0 170.9 238.4 145.7 106.6 150.3 159.8 149.3 164.1 177.7 152.8 167.5 234.4 139.4 149.2 172.6 134.0 155.5 132.1 170.4 423.4 85.3 142.9 164.7 278.7 214.3 327.1 165.9 256.6 200.9 297.8 167.8 170.3 214.7 241.1 148.2 149.6 149.5 202.6 249.5 186.3 196.5 260.9 42.5 44.0 46.1 49.3 45.2 45.2 39.3 42.3 40.2 42.2 47.1 42.1 109.5 51.3 67.0 16.3 172.8 178.6 186.4 275.6 97.3 64.6 101.9 105.7 89.1 84.4 140.9 62.5 50.1 312.8 153.9 77.4 105.7 211.9 64.4 66.6 100.6 118.3 102.3 127.4 17.2 148.2 293.1 134.4 55.5 104.6 109.5 149.7 94.2 43.7 213.5 47.1 16.8 97.1 162.8 104.8 182.1 37.8 129.8 124.8 128.1 15.9 220.2 104.7 209.1 16.6 26.7 212.3 91.8 107.6 144.1 294.8 90.4 117.7 65.7 63.1 78.9 82.1 185.4 139.6 145.7 158.4 206.7 418.1 144.7 134.9 134.7 304.5 UBE2J1 "CGI-76, HSPC153, NCUBE1, UBC6" ENSG00000198833 "Ubiquitin conjugating enzyme E2 J1" Q9Y385 6 89326625-89352722 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 5 "Early spermatids: 498.7;Late spermatids: 1426.6;Plasma cells: 1003.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Daudi: 294.1;Karpas-707: 247.4;U-266/70: 274.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003509, CAB073419" Enhanced NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 29: U-266 - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" "CAB073419: , HPA003509: AB_1858531" "unprognostic (1.82e-1)" "unprognostic (3.20e-2)" "unprognostic (1.55e-3)" "prognostic favorable (2.87e-4)" "unprognostic (3.41e-1)" "unprognostic (7.93e-3)" "prognostic unfavorable (6.90e-5)" "unprognostic (1.19e-1)" "unprognostic (9.36e-2)" "prognostic favorable (7.43e-4)" "unprognostic (1.74e-1)" "unprognostic (9.33e-2)" "prognostic unfavorable (1.11e-4)" "unprognostic (5.11e-2)" "unprognostic (2.83e-1)" "unprognostic (3.87e-2)" "unprognostic (9.38e-2)" 25.9 23.2 14.9 52.3 15.9 119.3 31.4 16.8 18.8 33.3 15.0 48.9 55.0 27.8 28.6 23.2 20.9 26.6 14.7 15.2 16.5 22.0 26.9 29.9 90.5 16.9 17.8 23.7 32.0 21.8 12.9 33.3 17.1 42.3 49.6 19.4 44.7 21.2 12.0 14.3 45.9 30.2 16.9 43.7 49.1 24.6 16.2 57.8 31.9 15.6 97.1 36.7 14.5 18.3 38.8 13.4 36.3 46.5 37.0 47.8 0.2 60.4 53.4 36.7 40.0 21.9 23.7 294.1 32.9 63.0 30.6 15.3 23.9 35.1 59.4 41.6 37.0 53.6 16.1 36.0 98.2 68.2 33.4 36.7 34.4 30.8 52.1 48.9 83.1 34.7 43.9 247.4 43.4 23.8 28.5 52.1 12.5 27.3 19.0 110.1 46.5 143.6 46.2 26.9 18.3 36.7 25.6 55.7 56.9 52.2 22.0 149.3 56.1 20.2 19.1 36.3 47.0 274.1 146.1 80.0 40.3 48.3 34.4 24.6 13.5 24.7 6.2 22.0 7.2 37.5 8.2 7.6 12.4 29.6 7.6 7.0 30.7 12.8 37.4 45.5 13.0 13.3 14.9 15.9 16.8 18.8 15.2 16.5 16.9 17.8 17.1 16.9 16.2 18.3 65.3 16.0 33.9 18.6 185.6 24.9 60.0 39.1 31.3 34.6 39.5 29.5 9.7 30.0 38.5 20.2 29.2 89.7 136.8 71.0 50.9 60.5 498.7 35.6 50.3 104.6 77.3 34.7 26.9 101.4 91.8 60.0 72.9 50.2 25.3 27.1 99.2 45.5 75.8 23.5 28.9 80.3 42.7 107.7 53.0 1426.6 54.7 105.5 72.9 23.4 65.4 18.6 30.9 26.2 31.0 112.0 74.3 47.8 1003.3 99.5 72.4 49.2 33.4 16.0 32.9 54.3 61.1 22.5 20.5 54.4 34.7 129.4 52.3 32.6 65.0 123.7 UBE2J2 "NCUBE2, Ubc6p" ENSG00000160087 "Ubiquitin conjugating enzyme E2 J2" Q8N2K1 1 1253909-1273864 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway, Unfolded protein response" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 261.9;Late spermatids: 452.3;Spermatocytes: 261.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 66: Spermatocytes - Spermatogenesis" "unprognostic (9.39e-2)" "unprognostic (1.17e-1)" "unprognostic (2.25e-1)" "unprognostic (3.04e-2)" "unprognostic (1.88e-2)" "unprognostic (4.46e-2)" "unprognostic (1.67e-3)" "unprognostic (1.60e-1)" "unprognostic (1.60e-2)" "unprognostic (9.57e-2)" "unprognostic (1.28e-3)" "unprognostic (1.32e-1)" "prognostic unfavorable (2.00e-4)" "unprognostic (2.09e-2)" "unprognostic (6.19e-2)" "unprognostic (1.87e-1)" "unprognostic (3.46e-2)" 31.4 36.3 23.1 24.5 23.6 22.8 29.8 26.9 26.3 30.2 22.4 36.4 23.2 33.9 12.2 44.0 32.8 16.5 37.1 23.8 22.4 35.0 45.8 30.0 25.6 24.8 23.0 29.6 35.7 20.1 35.3 19.8 23.8 32.2 15.9 14.9 30.9 15.1 50.8 39.4 34.7 19.3 22.2 44.6 37.2 105.2 23.1 23.9 29.5 21.3 22.7 30.6 29.4 27.2 70.0 30.3 40.4 39.6 31.9 32.1 31.6 50.8 44.3 73.0 53.5 54.3 50.2 37.4 52.6 50.4 40.0 49.6 42.6 55.0 57.5 64.5 68.8 58.2 64.3 47.9 62.9 56.1 50.6 31.1 30.1 58.1 42.2 39.6 53.3 52.1 80.0 38.7 43.2 38.1 82.4 63.8 45.3 47.3 67.7 74.3 40.8 63.8 37.9 25.3 140.9 73.9 38.5 80.4 89.8 36.9 42.9 62.2 36.5 44.8 40.9 53.0 56.2 79.2 88.9 114.3 58.9 83.5 36.8 83.4 36.5 69.3 33.7 37.0 31.3 37.1 35.4 35.3 36.1 32.5 32.7 32.5 54.0 39.7 38.7 34.5 42.4 29.5 23.1 23.6 26.9 26.3 23.8 22.4 24.8 23.0 23.8 22.2 23.1 27.2 32.8 9.6 17.3 18.9 34.0 42.7 51.7 71.4 23.9 31.3 28.5 29.5 18.9 32.9 40.8 29.5 8.4 71.7 53.3 44.0 56.7 70.9 261.9 25.3 28.5 34.3 17.5 45.6 12.8 93.2 71.5 34.5 33.1 25.3 16.5 32.6 31.8 30.3 52.1 23.5 14.3 35.6 54.9 31.1 41.2 452.3 37.6 31.7 40.9 12.2 44.3 33.2 70.0 8.5 16.4 105.4 33.8 37.6 50.9 76.6 54.4 73.2 23.4 29.9 32.9 29.8 40.1 261.0 100.6 38.3 43.8 87.3 35.7 40.6 40.7 61.8 UBE2K "HIP2, HYPG, UBC1" ENSG00000078140 "Ubiquitin conjugating enzyme E2 K" P61086 4 39698109-39782792 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028869, CAB033212, CAB033515" Supported Approved "Plasma membrane,Cytosol" NA NA 390000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Cytosol "Plasma membrane" "CAB033212: AB_2272506, CAB033515: AB_2304024, HPA028869: AB_10602487" "unprognostic (1.14e-2)" "unprognostic (6.02e-2)" "unprognostic (2.42e-3)" "unprognostic (3.06e-1)" "unprognostic (6.81e-2)" "unprognostic (2.05e-1)" "unprognostic (5.05e-3)" "unprognostic (1.44e-2)" "unprognostic (2.71e-3)" "unprognostic (1.01e-1)" "prognostic unfavorable (8.60e-4)" "unprognostic (1.08e-1)" "unprognostic (3.67e-1)" "unprognostic (4.83e-2)" "unprognostic (6.88e-2)" "unprognostic (1.22e-1)" "unprognostic (4.10e-3)" 29.9 19.4 13.5 23.4 17.5 21.4 21.7 20.9 24.5 16.0 9.2 35.8 31.2 17.8 17.7 26.2 12.7 12.9 18.4 18.3 14.9 26.7 45.4 16.4 20.1 12.9 14.0 13.6 13.2 20.4 15.8 24.4 13.1 19.8 24.2 21.0 16.9 14.9 37.3 22.6 24.8 17.2 7.8 18.0 31.8 16.5 14.2 22.4 23.8 25.6 18.0 20.2 17.2 16.0 91.3 90.7 49.3 45.6 29.8 28.7 82.8 122.8 26.4 32.8 34.0 138.0 91.1 114.3 105.2 35.0 79.8 39.0 95.4 54.7 51.9 76.1 70.0 145.7 88.9 121.6 38.4 159.0 79.6 27.1 60.2 46.0 49.0 35.2 43.3 49.3 152.9 39.6 33.9 86.6 111.5 89.9 67.7 54.4 69.8 66.3 144.0 44.2 46.0 123.9 103.9 47.4 91.7 34.5 58.9 54.1 44.4 58.2 116.9 49.9 105.7 60.0 114.5 55.3 174.0 121.4 26.9 101.4 59.5 19.6 18.1 24.8 14.4 16.9 13.4 20.7 15.0 13.8 19.7 14.7 11.2 12.6 15.1 14.0 25.4 27.6 16.0 10.5 13.5 17.5 20.9 24.5 18.3 14.9 12.9 14.0 13.1 7.8 14.2 16.0 63.2 57.7 63.1 69.2 53.0 122.9 65.5 74.3 59.7 62.2 65.3 52.5 72.3 52.9 66.7 49.7 29.2 84.5 76.5 143.7 66.5 83.5 144.9 72.0 82.3 65.6 59.7 85.8 115.9 89.4 168.7 59.2 68.3 90.9 34.8 40.1 63.5 113.6 80.2 104.3 113.8 74.5 65.1 77.1 91.8 202.4 65.3 76.5 56.9 89.0 104.0 87.1 56.7 87.0 118.2 139.6 94.3 56.4 55.5 111.4 75.3 98.0 60.7 42.9 39.5 61.8 121.1 145.2 55.1 74.3 137.9 147.5 61.3 54.8 74.1 107.0 UBE2L3 UBCH7 ENSG00000185651 "Ubiquitin conjugating enzyme E2 L3" P68036 22 21549447-21624034 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "K-562: 544.4" "HPA045609, HPA062415" Approved Approved Nucleoplasm,Cytosol NA NA 5800000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 1: K-562 - Erythropoiesis" "Cluster 16: Pancreatic endocrine cells - Mixed function" "Nucleoplasm, Cytosol" "HPA045609: AB_10961322, HPA062415: AB_2684756" "unprognostic (4.90e-2)" "unprognostic (3.05e-1)" "unprognostic (1.92e-2)" "unprognostic (1.07e-2)" "unprognostic (2.74e-2)" "unprognostic (9.99e-3)" "prognostic unfavorable (1.29e-4)" "unprognostic (3.28e-2)" "unprognostic (3.65e-2)" "prognostic favorable (3.82e-6)" "unprognostic (3.53e-2)" "unprognostic (4.55e-2)" "unprognostic (3.18e-2)" "unprognostic (4.66e-2)" "unprognostic (5.09e-2)" "unprognostic (2.77e-1)" "unprognostic (3.15e-3)" 41.5 46.0 63.7 37.1 64.8 54.4 33.9 65.0 72.0 35.5 54.4 45.5 39.6 35.0 41.0 49.1 38.5 34.0 51.5 65.4 65.3 40.1 40.9 33.9 48.8 67.8 64.7 33.9 30.3 43.2 31.2 42.7 66.8 39.1 45.6 28.1 33.9 36.8 63.5 36.2 40.7 48.6 62.3 37.6 37.5 28.5 66.7 51.9 36.4 53.1 52.5 46.8 32.3 65.5 121.9 68.9 98.3 77.4 105.1 93.1 56.6 100.0 113.6 125.8 118.7 79.0 57.0 114.2 49.0 133.5 94.7 101.4 132.1 108.6 124.3 114.4 142.9 132.1 63.3 94.8 70.0 190.9 91.0 82.7 93.1 91.2 65.7 90.6 143.4 69.4 544.4 59.3 137.9 89.6 100.0 137.6 72.8 134.8 71.6 80.5 147.6 31.2 118.8 96.2 88.0 65.4 79.9 99.1 95.6 89.4 61.7 104.0 103.8 88.6 113.5 75.5 103.6 57.3 99.7 103.7 120.0 87.5 86.0 84.4 87.8 105.7 84.9 102.2 79.7 77.3 79.9 91.6 109.2 73.6 69.0 82.9 73.2 81.2 89.0 106.3 106.1 141.1 63.7 64.8 65.0 72.0 65.4 65.3 67.8 64.7 66.8 62.3 66.7 65.5 102.6 109.0 83.9 26.1 110.7 125.5 171.6 318.5 51.2 54.5 76.9 72.8 64.9 101.5 180.3 71.7 16.7 312.1 159.0 215.1 197.6 288.2 79.9 133.1 104.6 125.9 126.0 173.0 25.6 385.0 406.5 102.6 60.1 124.9 129.3 79.3 109.6 159.8 298.5 69.0 24.3 153.1 193.3 126.9 159.7 61.1 87.3 140.9 126.3 19.7 257.9 98.4 200.8 22.6 30.4 432.1 222.1 103.8 98.4 186.7 213.5 257.2 173.9 45.5 105.2 81.0 205.4 202.8 121.2 87.6 129.7 372.1 130.1 133.7 154.0 208.4 UBE2L6 UBCH8 ENSG00000156587 "Ubiquitin conjugating enzyme E2 L6" O14933 11 57551656-57568284 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hofbauer cells: 165.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003328, CAB073407" Enhanced Approved Cytosol NA NA 15000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "CAB073407: , HPA003328: AB_1858539" "prognostic favorable (6.75e-4)" "unprognostic (2.10e-2)" "unprognostic (1.09e-2)" "unprognostic (2.93e-2)" "unprognostic (1.72e-1)" "unprognostic (1.18e-1)" "unprognostic (3.13e-2)" "unprognostic (4.74e-2)" "unprognostic (1.36e-2)" "unprognostic (1.37e-3)" "prognostic unfavorable (4.88e-4)" "unprognostic (3.07e-2)" "unprognostic (1.02e-2)" "unprognostic (1.28e-1)" "unprognostic (4.17e-2)" "unprognostic (1.88e-2)" "unprognostic (6.42e-2)" 70.7 60.4 84.4 92.3 84.8 85.5 51.1 80.0 95.2 54.2 70.7 46.3 47.6 44.1 68.5 42.7 66.1 66.6 35.2 80.2 88.0 51.5 121.1 91.1 119.9 93.6 88.1 61.5 24.3 39.9 36.8 53.1 86.2 47.0 43.6 23.6 103.3 49.2 14.3 36.1 57.6 67.3 96.2 126.4 55.6 17.1 94.6 113.4 37.4 29.3 86.7 76.0 44.4 86.1 55.6 26.2 85.8 29.0 179.2 222.3 9.7 30.2 178.8 261.3 337.0 9.8 140.9 169.3 110.3 92.5 223.3 43.7 38.0 99.4 55.4 163.9 1.5 169.2 0.0 38.0 330.7 38.8 54.3 238.9 22.9 122.8 33.6 96.2 83.9 173.2 7.9 118.5 47.8 67.6 280.1 92.2 23.3 0.5 33.3 243.1 52.9 118.4 71.0 58.5 2.1 45.2 60.3 5.4 139.9 15.3 68.3 20.3 30.9 56.3 19.6 43.6 10.2 162.1 176.6 3.4 161.0 98.8 12.3 508.1 534.8 487.8 359.2 638.4 394.1 379.2 368.2 377.9 401.3 310.9 315.1 331.1 838.8 486.9 556.7 256.3 513.7 1060.5 84.4 84.8 80.0 95.2 80.2 88.0 93.6 88.1 86.2 96.2 94.6 86.1 94.6 28.9 22.2 2.9 53.5 23.3 26.2 75.7 26.2 12.4 31.9 38.7 6.0 24.3 38.2 12.9 4.2 4.2 59.3 16.4 64.6 95.4 4.9 16.6 83.4 65.5 23.9 53.0 2.0 65.2 38.1 43.8 23.0 16.4 53.9 41.3 53.2 35.3 165.3 13.5 4.8 38.6 48.8 77.4 36.9 10.9 48.1 73.1 8.8 9.4 79.0 54.0 97.9 3.5 2.0 37.3 48.1 33.4 51.4 52.8 47.7 32.3 33.3 4.4 26.3 15.4 33.8 2.4 9.8 25.6 27.7 3.4 68.8 26.9 22.7 33.3 UBE2M "hUbc12, UBC12" ENSG00000130725 "Ubiquitin conjugating enzyme E2 M" P61081 19 58555712-58558954 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HEK 293: 1197.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004993, HPA054551, HPA057800" Approved Enhanced "Nucleoplasm,Nucleoli,Nuclear bodies,Cytosol" Yes No 49000 "Cluster 50: Neutrophils - Cellular senescence" "Cluster 39: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "Nucleoli, Nuclear bodies, Cytosol" "CAB004993: AB_436983, HPA054551: AB_2682520, HPA057800: AB_2683531" "unprognostic (1.42e-1)" "unprognostic (1.99e-1)" "unprognostic (1.63e-2)" "unprognostic (1.39e-1)" "unprognostic (8.35e-2)" "unprognostic (1.77e-1)" "unprognostic (1.17e-3)" "unprognostic (3.90e-3)" "unprognostic (4.86e-2)" "unprognostic (1.09e-2)" "unprognostic (3.05e-3)" "unprognostic (1.96e-1)" "unprognostic (1.81e-1)" "unprognostic (8.63e-3)" "unprognostic (1.76e-1)" "unprognostic (5.85e-2)" "unprognostic (8.42e-3)" 46.3 66.1 133.2 39.2 138.8 82.2 42.8 116.7 199.7 48.9 104.0 72.5 41.7 48.1 36.3 61.8 51.3 30.9 111.0 141.2 129.3 63.2 45.6 46.3 43.4 123.5 124.4 46.0 47.5 84.5 69.7 45.0 127.7 48.3 32.5 49.7 48.5 46.1 174.0 56.6 41.6 39.5 111.9 49.3 55.8 81.0 124.4 51.7 44.3 104.5 43.7 58.3 45.8 139.1 161.8 272.1 119.3 124.8 61.7 71.9 112.2 166.0 117.4 97.8 82.8 162.7 109.7 161.9 135.5 93.4 198.1 105.9 130.1 138.6 69.2 207.3 1197.4 235.5 163.7 113.7 154.4 197.3 192.9 82.1 107.1 145.9 167.3 102.6 117.8 146.3 119.6 179.4 127.3 158.2 177.2 223.7 87.1 155.1 306.5 171.7 106.7 204.5 111.6 166.8 239.5 205.5 133.1 149.7 163.3 41.6 94.4 188.4 105.2 333.4 80.5 110.6 281.3 262.3 411.9 169.6 206.0 177.6 220.5 6.7 3.6 4.2 3.0 2.6 2.2 2.8 3.2 3.2 2.8 3.8 3.3 2.2 10.1 1.7 2.7 6.7 2.9 1.9 133.2 138.8 116.7 199.7 141.2 129.3 123.5 124.4 127.7 111.9 124.4 139.1 75.1 6.4 13.0 14.7 32.7 40.4 36.3 15.9 6.2 100.0 74.5 81.3 38.5 20.0 11.6 18.4 20.9 21.0 72.9 63.9 7.9 17.3 25.7 89.6 68.0 40.1 41.2 39.8 22.9 30.6 22.4 38.9 21.9 63.3 19.7 103.3 28.5 38.0 35.4 109.4 20.8 43.8 20.3 27.0 33.5 34.0 17.4 42.5 35.6 15.9 21.1 142.3 14.4 8.5 17.9 41.8 21.4 13.9 35.4 59.1 37.9 33.9 18.6 81.1 26.3 41.5 55.4 27.1 7.9 17.0 56.8 52.5 41.0 156.1 41.6 56.2 UBE2N "MGC8489, UBC13, UbcH-ben" ENSG00000177889 "Ubiquitin conjugating enzyme E2 N" P61088 12 93405673-93441947 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 15 "Early spermatids: 2532.0;Late spermatids: 8141.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044976 Enhanced Supported "Nucleoplasm,Nucleoli fibrillar center" NA NA 1800000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "Nucleoli fibrillar center" "HPA044976: AB_2679163" "unprognostic (1.74e-2)" "unprognostic (5.53e-1)" "unprognostic (1.26e-2)" "unprognostic (2.30e-1)" "unprognostic (1.07e-1)" "unprognostic (8.09e-2)" "prognostic unfavorable (2.41e-4)" "unprognostic (8.49e-3)" "unprognostic (2.72e-1)" "unprognostic (4.28e-3)" "unprognostic (1.07e-1)" "unprognostic (9.28e-2)" "unprognostic (1.03e-1)" "unprognostic (3.31e-2)" "unprognostic (1.29e-1)" "unprognostic (1.48e-1)" "unprognostic (1.30e-3)" 52.4 48.6 46.4 62.1 49.9 69.9 41.6 40.3 51.6 35.8 26.8 55.9 42.5 44.0 38.3 60.4 37.3 33.5 57.6 50.8 53.2 54.4 45.5 38.2 80.0 45.2 43.9 31.3 30.6 40.4 32.6 49.5 52.2 46.0 44.0 50.3 36.0 34.5 83.0 41.3 42.3 42.7 44.3 42.9 41.0 186.9 44.3 79.4 29.0 70.3 73.8 76.4 38.6 44.4 190.3 133.2 221.1 142.6 82.9 81.4 154.5 259.4 135.6 201.0 167.3 239.8 80.0 380.2 57.3 151.1 133.8 147.7 245.2 188.7 189.7 323.3 128.4 258.0 66.6 214.2 106.4 311.9 165.1 86.3 75.2 120.8 148.9 143.1 157.3 146.9 292.8 58.0 210.9 155.3 310.4 286.2 288.9 165.9 189.4 237.3 179.9 186.6 170.1 280.9 214.9 195.6 136.1 158.5 130.0 118.7 207.5 188.0 165.8 135.7 114.6 124.1 189.9 99.5 289.4 324.0 53.5 162.5 170.2 133.7 89.5 101.3 99.3 123.3 116.8 174.0 124.8 124.1 119.6 144.7 109.3 104.9 27.7 106.0 141.7 89.6 198.6 202.5 46.4 49.9 40.3 51.6 50.8 53.2 45.2 43.9 52.2 44.3 44.3 44.4 87.5 38.5 45.8 24.8 151.4 322.2 231.3 219.1 92.2 72.1 84.3 60.5 74.6 60.1 112.2 90.1 27.1 236.0 104.3 76.3 191.7 141.4 2532.0 79.7 79.0 95.3 74.7 75.9 44.6 99.0 226.0 100.9 49.5 96.5 93.8 68.3 55.3 55.3 165.6 87.5 49.0 78.6 187.2 67.8 216.3 8141.3 93.8 97.0 147.7 33.7 152.9 111.9 79.3 38.7 42.1 135.5 83.8 86.1 113.3 218.2 61.2 171.3 88.9 57.6 46.0 101.9 146.2 338.4 227.6 142.2 322.5 284.7 128.2 86.4 94.9 260.3 UBE2O E2-230K ENSG00000175931 "Ubiquitin conjugating enzyme E2 O" Q9C0C9 17 76389456-76453152 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transport, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 54.7;Inhibitory neurons: 63.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA023605 Uncertain Supported "Nucleoplasm,Nuclear bodies" No No 220000 "Cluster 21: B-cells - Adaptive immune response" "Cluster 39: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 62: Horizontal cells - Visual perception" "Nuclear bodies" Nucleoplasm "HPA023605: AB_2671257" "unprognostic (8.75e-2)" "unprognostic (2.04e-1)" "unprognostic (7.44e-2)" "unprognostic (8.68e-2)" "unprognostic (1.17e-1)" "unprognostic (3.22e-2)" "prognostic unfavorable (6.84e-8)" "unprognostic (3.54e-1)" "unprognostic (2.68e-1)" "unprognostic (7.61e-2)" "unprognostic (1.32e-3)" "unprognostic (1.18e-2)" "prognostic unfavorable (4.34e-9)" "unprognostic (7.22e-2)" "unprognostic (9.64e-2)" "unprognostic (9.12e-2)" "unprognostic (2.07e-1)" 9.1 9.7 12.9 10.1 14.0 21.2 9.7 8.0 24.9 12.8 1.4 10.7 9.4 11.5 7.0 12.8 11.0 6.5 20.3 15.4 11.7 8.4 10.5 8.7 13.1 21.7 9.0 15.1 17.4 10.9 18.2 9.1 21.7 11.6 5.3 10.5 12.9 8.7 28.3 16.1 10.6 7.1 4.4 13.9 11.0 16.6 11.6 12.0 16.1 13.4 8.6 10.8 12.5 14.5 25.8 29.2 29.1 35.5 17.7 11.3 25.2 11.8 12.8 18.9 18.3 25.6 12.7 36.4 8.3 14.8 29.7 25.2 34.2 20.4 13.2 10.5 42.2 36.9 20.6 42.9 14.7 22.6 22.0 11.4 16.2 18.1 15.3 16.2 25.7 19.9 31.5 31.4 9.6 21.3 44.7 26.0 27.0 15.5 38.9 43.3 37.6 40.2 8.5 22.1 43.0 38.5 17.4 43.9 23.6 26.3 25.4 16.1 15.4 21.9 20.5 18.8 19.9 25.8 9.2 30.8 24.1 18.8 14.6 0.0 0.7 1.0 1.4 0.3 0.8 0.9 0.9 0.7 0.4 1.6 0.7 1.1 0.1 0.5 0.4 1.5 0.9 0.8 12.9 14.0 8.0 24.9 15.4 11.7 21.7 9.0 21.7 4.4 11.6 14.5 7.9 3.2 7.7 24.8 19.6 8.7 6.1 7.2 13.1 45.8 9.7 9.1 23.2 5.7 7.3 7.3 41.7 6.4 15.2 6.5 0.0 6.0 1.8 8.6 13.7 8.3 23.4 33.2 54.7 9.4 7.4 8.3 17.9 10.1 7.0 18.9 7.1 8.5 8.1 45.4 63.0 9.3 2.0 5.3 11.0 1.8 9.6 11.6 5.4 19.7 10.0 7.3 18.6 27.2 24.7 7.2 5.7 7.9 22.9 9.8 5.2 3.3 5.6 23.8 6.6 12.2 10.9 19.6 23.2 12.9 12.4 5.2 14.7 13.3 8.7 6.2 UBE2Q1 "NICE-5, PRO3094, UBE2Q" ENSG00000160714 "Ubiquitin conjugating enzyme E2 Q1" Q7Z7E8 1 154548577-154559028 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063368 Approved Approved Nucleoplasm,Centrosome,Cytosol No No "Cluster 15: NK-cells - Transcription" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 43: THP-1 - Innate immune response" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "Centrosome, Cytosol" "HPA063368: AB_2684996" "unprognostic (3.88e-1)" "unprognostic (2.13e-1)" "unprognostic (4.44e-3)" "unprognostic (3.64e-3)" "unprognostic (5.32e-3)" "unprognostic (6.10e-3)" "prognostic unfavorable (8.74e-4)" "unprognostic (2.92e-1)" "unprognostic (2.07e-1)" "unprognostic (9.92e-3)" "unprognostic (3.79e-2)" "unprognostic (1.46e-1)" "prognostic unfavorable (4.84e-7)" "unprognostic (2.20e-1)" "unprognostic (4.46e-1)" "prognostic favorable (1.86e-5)" "unprognostic (1.04e-2)" 25.4 23.1 36.1 19.0 37.0 32.2 22.4 34.5 43.3 21.2 35.2 24.3 18.7 21.8 27.2 27.4 23.7 19.9 25.9 37.3 38.0 28.8 31.6 25.0 29.5 36.0 36.0 23.1 31.8 28.3 31.3 23.9 37.5 21.2 28.2 25.9 22.5 20.9 26.3 26.7 25.5 24.4 35.5 32.3 26.8 34.6 38.2 29.8 23.0 25.8 35.2 25.7 22.2 36.2 39.0 33.0 45.6 35.0 45.8 46.9 39.4 38.0 57.0 47.3 38.0 37.3 40.4 47.5 53.3 52.8 39.5 33.0 54.3 43.6 40.5 48.7 34.3 37.8 29.6 36.4 57.5 62.1 58.3 45.5 56.7 38.5 44.1 51.3 61.8 43.3 32.4 57.1 61.3 60.4 38.1 45.6 62.5 92.3 55.5 43.4 31.8 50.3 52.4 40.6 46.2 64.6 38.1 70.6 64.5 77.5 43.3 93.2 43.3 30.5 34.1 36.5 41.2 69.3 55.2 62.1 34.2 43.2 47.1 3.9 1.3 2.9 2.1 1.6 2.0 1.4 2.0 2.7 1.2 1.5 2.2 2.5 2.0 2.3 1.3 2.4 3.1 0.8 36.1 37.0 34.5 43.3 37.3 38.0 36.0 36.0 37.5 35.5 38.2 36.2 40.8 32.1 26.5 9.8 24.7 16.2 18.0 15.9 15.4 41.2 27.3 32.5 29.4 27.1 18.4 16.5 4.2 19.8 45.2 33.4 11.7 14.5 4.5 24.8 20.9 32.8 33.6 12.0 12.2 21.0 18.2 23.3 14.3 24.9 10.8 31.9 35.3 38.3 27.5 60.6 11.7 29.2 22.4 48.0 19.7 7.3 17.7 27.9 14.2 10.3 30.9 42.8 39.1 7.1 11.7 26.2 18.5 19.2 22.1 29.5 29.6 19.7 29.0 23.1 13.1 20.1 21.2 34.1 29.2 18.1 19.0 19.6 26.5 36.3 25.7 31.4 UBE2Q2 DKFZp762C143 ENSG00000140367 "Ubiquitin conjugating enzyme E2 Q2" Q8WVN8 15 75843307-75901078 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Rod photoreceptor cells: 160.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 9: Photoreceptor cells - Phototransduction" "unprognostic (1.28e-1)" "unprognostic (1.66e-2)" "unprognostic (2.45e-2)" "unprognostic (4.28e-2)" "unprognostic (8.82e-2)" "unprognostic (1.13e-1)" "unprognostic (1.07e-3)" "unprognostic (1.32e-1)" "unprognostic (6.38e-2)" "prognostic favorable (5.73e-4)" "unprognostic (1.67e-1)" "unprognostic (1.87e-1)" "unprognostic (1.47e-3)" "unprognostic (1.01e-3)" "unprognostic (1.92e-1)" "unprognostic (1.69e-2)" "unprognostic (5.92e-2)" 24.3 26.7 18.3 16.7 19.3 40.2 24.4 20.0 28.9 25.5 15.0 37.2 9.3 24.9 18.8 22.5 17.4 22.3 29.5 18.3 21.9 22.5 7.2 19.2 18.6 21.8 22.7 22.8 19.4 17.4 16.1 29.0 22.4 30.4 19.8 39.0 25.4 20.9 23.0 16.5 15.7 30.5 22.9 21.7 19.5 21.1 19.9 21.0 31.8 16.9 17.7 27.1 17.0 24.4 23.0 35.5 30.0 22.6 42.8 56.7 47.2 50.4 57.2 32.8 37.1 18.7 30.7 22.7 36.2 73.5 27.8 18.1 58.5 33.5 39.9 24.1 23.7 28.5 20.1 24.5 48.1 28.9 15.7 40.7 37.4 23.1 33.4 46.3 46.2 40.5 11.3 33.2 70.1 18.0 24.7 27.6 22.4 3.5 25.3 29.5 47.2 9.4 51.8 36.8 27.4 21.6 42.4 39.6 55.6 42.3 25.6 40.3 60.7 40.2 36.1 27.3 17.8 36.3 68.1 17.6 15.9 44.9 25.2 31.3 6.3 21.3 9.0 7.3 11.2 8.1 11.8 9.7 5.7 7.8 9.4 7.9 0.9 14.6 10.0 2.1 8.4 6.4 18.3 19.3 20.0 28.9 18.3 21.9 21.8 22.7 22.4 22.9 19.9 24.4 54.3 3.2 6.5 17.6 29.0 50.3 27.7 12.9 33.6 30.3 39.3 26.0 32.1 18.6 17.4 23.9 135.5 55.0 42.6 9.4 23.5 23.8 95.7 18.3 47.4 40.7 18.6 19.1 15.2 16.9 126.2 38.2 12.2 28.9 20.3 27.8 36.4 4.7 23.0 6.7 22.6 30.0 26.4 25.9 51.8 36.7 24.2 34.0 37.4 17.8 30.6 20.2 68.0 30.7 29.5 22.5 10.7 29.0 43.3 58.4 1.3 39.6 9.3 160.8 26.3 28.9 42.9 64.8 64.4 34.4 46.5 110.0 36.1 28.3 17.7 38.7 UBE2QL1 FLJ25076 ENSG00000215218 "Ubiquitin conjugating enzyme E2 Q family like 1" A1L167 5 6448859-6496723 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 26.1;heart muscle: 16.8;retina: 28.3;skeletal muscle: 54.5;tongue: 13.9" "Cell type enhanced" "Detected in many" "Bipolar cells: 30.0;Cardiomyocytes: 27.6;Excitatory neurons: 47.8;Granulosa cells: 45.5;Horizontal cells: 45.4;Inhibitory neurons: 35.3;Rod photoreceptor cells: 63.6" "Cancer enhanced" "Detected in many" "thyroid cancer: 5.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "Karpas-707: 29.7;PC-3: 24.6;SCLC-21H: 23.1;U-266/70: 54.4;U-266/84: 52.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA057414 Supported "Nucleoplasm,Plasma membrane" NA NA "Cluster 54: Non-specific - Microtubule organization" "Cluster 29: U-266 - Adaptive immune response" "Cluster 46: Photoreceptor cells - Phototransduction" Nucleoplasm "Plasma membrane" "HPA057414: " "unprognostic (1.45e-2)" "unprognostic (1.58e-2)" "unprognostic (1.79e-2)" "unprognostic (2.10e-1)" "unprognostic (1.08e-2)" "unprognostic (7.43e-2)" "unprognostic (1.15e-2)" "unprognostic (1.36e-1)" "unprognostic (3.10e-1)" "unprognostic (7.16e-2)" "unprognostic (2.15e-3)" "unprognostic (8.41e-2)" "prognostic favorable (6.81e-8)" "unprognostic (3.18e-3)" "unprognostic (2.81e-1)" "unprognostic (1.27e-2)" "unprognostic (1.41e-2)" 1.2 1.4 14.3 0.4 14.6 0.0 1.1 16.5 26.1 2.1 1.8 5.3 0.3 0.8 1.0 0.4 0.7 0.4 16.8 17.9 11.4 3.4 1.2 0.1 0.1 12.0 7.9 2.6 0.6 0.1 3.2 0.0 11.6 3.5 0.3 28.3 0.8 5.5 54.5 1.5 1.4 0.7 5.6 0.2 2.9 0.7 10.1 0.3 1.2 13.9 0.2 0.3 1.3 17.7 0.1 0.0 0.0 0.3 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 29.7 0.0 5.3 0.0 0.0 0.3 0.0 24.6 0.1 0.0 11.5 0.0 0.0 23.1 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 54.4 52.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.3 14.6 16.5 26.1 17.9 11.4 12.0 7.9 11.6 5.6 10.1 17.7 0.2 0.0 0.0 5.5 0.3 1.3 0.5 0.5 0.0 30.0 0.4 1.0 27.6 0.0 0.0 0.0 6.2 0.0 0.0 0.0 5.9 0.0 0.0 0.2 0.4 1.0 5.4 0.0 47.8 0.2 0.0 3.6 1.1 0.1 0.0 45.5 0.0 1.0 0.1 45.4 35.3 0.0 0.0 0.3 0.3 0.3 4.1 0.1 0.0 2.8 0.0 9.4 0.0 12.1 5.4 0.1 0.0 6.8 1.8 0.9 0.0 0.2 0.0 63.6 0.0 3.2 1.4 0.1 0.3 0.0 0.1 0.0 0.0 0.5 0.0 0.0 UBE2R2 "CDC34B, FLJ20419, MGC10481, UBC3B" ENSG00000107341 "Ubiquitin conjugating enzyme E2 R2" Q712K3 9 33817160-33920399 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 311.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA061000, HPA074334" Approved Nucleoplasm,Nucleoli,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 59: Non-specific - Translation" "Cluster 12: NES - Nervous system development" "Cluster 34: Spermatids - Unknown function" "Nucleoplasm, Nucleoli" Cytosol "HPA061000: AB_2684408, HPA074334: " "unprognostic (1.51e-1)" "unprognostic (1.50e-1)" "unprognostic (7.08e-2)" "unprognostic (1.53e-1)" "unprognostic (6.55e-2)" "unprognostic (5.15e-2)" "prognostic unfavorable (4.37e-4)" "unprognostic (1.82e-3)" "unprognostic (4.61e-3)" "unprognostic (3.05e-3)" "unprognostic (2.22e-2)" "unprognostic (4.19e-1)" "unprognostic (2.01e-2)" "unprognostic (4.18e-2)" "unprognostic (1.22e-1)" "unprognostic (5.72e-2)" "unprognostic (1.43e-1)" 32.0 20.6 25.4 20.2 27.3 15.4 27.1 24.8 28.0 30.8 20.8 31.4 28.0 28.5 16.3 29.2 23.9 18.6 32.4 24.8 24.6 22.1 33.3 28.2 21.7 27.2 25.8 30.1 53.4 14.5 15.0 23.9 26.7 20.9 19.6 25.0 21.5 18.4 63.1 34.5 24.8 25.9 24.5 23.1 22.1 44.8 25.0 30.1 18.3 44.8 25.4 26.6 28.7 30.2 41.2 42.0 78.7 35.0 42.0 68.2 25.1 34.7 46.5 38.7 38.3 34.0 28.7 33.9 14.4 47.2 28.3 17.8 41.5 38.5 41.8 58.3 22.7 28.7 43.7 43.3 60.1 34.6 31.0 58.4 55.6 31.8 59.2 61.5 65.8 39.8 28.0 35.0 38.7 22.6 68.0 91.4 46.2 33.1 34.7 63.2 24.0 17.6 41.1 28.9 37.6 45.4 40.1 35.2 27.0 49.5 31.3 41.9 50.3 37.8 35.4 26.8 32.9 23.5 23.0 46.5 36.0 19.7 83.5 22.6 10.9 6.3 2.8 11.1 1.7 4.6 2.6 2.2 6.1 4.8 2.5 2.3 31.7 7.4 18.7 3.7 3.3 4.0 25.4 27.3 24.8 28.0 24.8 24.6 27.2 25.8 26.7 24.5 25.0 30.2 73.7 22.4 30.7 39.8 38.6 105.5 46.3 26.1 32.5 65.8 57.8 60.8 134.8 57.2 26.8 22.0 14.6 69.5 46.4 64.7 15.6 49.7 311.1 65.7 84.9 74.9 72.0 36.6 67.8 69.4 82.0 57.4 25.5 81.8 13.3 99.2 84.9 88.3 76.6 60.6 67.0 55.4 32.6 123.5 112.2 257.4 67.1 110.6 35.6 40.3 116.4 124.3 42.2 45.2 127.8 84.7 49.1 76.0 24.0 83.9 79.1 59.8 25.0 31.2 59.2 48.3 55.6 94.4 64.6 41.8 120.5 82.8 34.9 68.0 48.7 121.2 UBE2S E2-EPF ENSG00000108106 "Ubiquitin conjugating enzyme E2 S" Q16763 19 55399745-55407788 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 115.9;testis: 158.3" "Cell type enhanced" "Detected in many" "Breast myoepithelial cells: 341.4;dendritic cells: 432.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB015228, HPA057150" Approved Approved "Nucleoplasm,Plasma membrane" NA Yes "Cluster 37: B-cells - Transcription" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 7: Non-specific - Mitochondria" "Plasma membrane" Nucleoplasm "CAB015228: , HPA057150: AB_2683351" "unprognostic (2.79e-1)" "unprognostic (2.42e-1)" "unprognostic (2.57e-1)" "prognostic unfavorable (2.05e-4)" "unprognostic (9.54e-2)" "unprognostic (1.41e-1)" "prognostic unfavorable (8.00e-6)" "unprognostic (1.42e-3)" "unprognostic (2.32e-1)" "unprognostic (2.31e-1)" "unprognostic (8.08e-2)" "unprognostic (4.52e-2)" "prognostic unfavorable (8.16e-8)" "unprognostic (1.05e-1)" "unprognostic (9.51e-2)" "unprognostic (1.58e-1)" "unprognostic (1.75e-1)" 16.3 17.6 17.1 21.8 17.3 115.9 11.0 15.7 23.7 16.8 10.9 18.5 11.4 17.2 5.5 37.1 15.1 13.1 24.8 25.2 23.8 13.0 11.5 16.2 35.7 17.0 16.5 14.8 7.7 6.8 28.8 13.6 22.2 15.1 9.3 9.4 12.0 6.2 15.5 12.0 16.2 15.0 16.7 25.7 17.6 158.3 18.9 47.8 10.3 5.7 30.9 16.2 17.8 21.3 532.9 279.4 241.3 193.8 15.3 21.6 42.9 419.3 126.1 253.2 229.1 191.1 183.6 508.6 169.5 106.4 304.5 152.9 243.6 109.5 111.4 402.0 810.5 305.8 162.8 62.5 45.1 370.0 286.0 23.8 30.2 186.7 179.1 55.0 100.6 272.7 310.0 347.0 161.3 139.5 503.2 191.3 605.3 147.2 470.6 437.4 185.5 185.8 69.2 111.5 609.3 330.0 534.5 131.2 248.6 72.6 93.8 198.1 155.9 151.9 432.8 130.7 1013.5 277.1 734.4 617.0 159.2 257.5 562.7 0.5 0.8 1.3 0.7 0.6 0.5 2.5 1.0 1.0 0.6 0.6 1.0 0.5 2.4 0.2 0.4 1.3 0.4 0.1 17.1 17.3 15.7 23.7 25.2 23.8 17.0 16.5 22.2 16.7 18.9 21.3 308.0 0.0 3.4 5.9 161.3 162.6 151.2 31.5 81.4 59.3 235.9 341.4 3.1 8.6 9.9 20.2 54.2 87.8 432.7 59.2 15.6 42.8 127.5 89.3 68.2 72.5 92.6 166.5 8.7 30.5 247.9 99.3 44.9 68.0 18.4 200.9 31.8 10.6 65.5 32.0 11.0 69.1 38.7 26.8 125.3 52.2 17.4 131.7 74.7 3.7 36.7 91.1 21.6 7.5 13.5 82.3 44.1 12.4 100.6 82.9 20.4 18.4 9.7 75.7 13.1 125.2 186.7 196.9 174.0 74.1 115.9 59.8 233.3 64.6 55.8 121.1 UBE2T "FANCT, HSPC150" ENSG00000077152 "Ubiquitin conjugating enzyme E2 T" Q9NPD8 1 202331657-202341980 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Disease variant, Fanconi anemia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 47.1" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 74.5;Erythroid cells: 134.3;Extravillous trophoblasts: 103.4;Spermatocytes: 114.1;Spermatogonia: 113.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA002831 Approved Nucleoplasm,Nucleoli NA Yes "Cluster 27: Non-specific - Gene expression" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoli Nucleoplasm "HPA002831: AB_1080445" "unprognostic (2.38e-3)" "unprognostic (6.37e-2)" "unprognostic (5.27e-2)" "unprognostic (5.19e-2)" "unprognostic (2.81e-1)" "unprognostic (6.13e-3)" "prognostic unfavorable (4.79e-6)" "unprognostic (1.71e-2)" "unprognostic (2.32e-2)" "prognostic favorable (6.90e-6)" "unprognostic (6.28e-3)" "unprognostic (2.85e-2)" "prognostic unfavorable (2.22e-16)" "unprognostic (5.37e-3)" "unprognostic (1.58e-1)" "unprognostic (1.20e-1)" "unprognostic (4.86e-2)" 2.3 3.7 6.6 10.4 6.5 28.7 4.5 5.8 13.7 4.1 5.0 13.1 8.7 4.5 4.4 10.6 3.3 2.5 11.3 6.8 7.4 3.5 3.2 3.0 19.0 6.5 6.6 1.0 0.7 4.4 3.0 10.1 6.9 2.1 15.5 2.5 2.7 3.1 17.2 5.3 8.2 9.4 6.0 6.2 4.7 19.3 6.7 47.1 2.9 13.0 18.6 6.3 5.0 6.1 123.3 111.6 167.1 79.8 15.4 27.9 94.2 130.2 72.8 146.0 102.6 79.9 147.1 140.4 50.0 47.0 108.4 98.6 154.1 76.7 131.2 128.1 87.2 85.6 54.0 93.8 6.9 105.2 102.0 9.8 18.1 114.0 47.2 34.3 85.8 157.4 111.0 114.0 116.4 113.3 190.8 135.1 65.4 126.9 57.4 145.0 176.2 122.9 57.1 58.1 131.3 132.8 90.2 112.1 44.8 49.8 117.1 64.6 41.8 65.7 104.6 116.1 159.6 57.8 120.1 182.9 64.5 107.0 139.1 0.0 0.7 1.7 3.3 2.3 2.5 8.5 4.5 3.3 1.7 6.6 6.4 7.1 0.0 1.2 8.9 3.4 10.8 2.4 6.6 6.5 5.8 13.7 6.8 7.4 6.5 6.6 6.9 6.0 6.7 6.1 1.9 0.0 2.2 1.3 13.3 14.3 10.4 29.9 2.8 6.4 6.3 8.6 12.8 0.0 12.1 5.5 0.0 74.5 5.4 10.1 5.9 10.9 24.4 15.7 7.6 5.3 1.2 134.3 8.3 7.5 103.4 11.8 10.7 6.7 8.8 32.2 3.9 2.4 27.7 10.1 6.1 14.4 32.6 1.9 5.4 8.2 3.1 5.8 3.6 1.9 2.6 1.6 0.0 1.0 1.4 10.3 2.9 4.1 32.1 5.2 3.3 12.2 16.2 1.2 6.6 0.8 11.3 114.1 113.1 15.5 10.9 22.4 9.3 12.1 30.5 11.3 UBE2U MGC35130 ENSG00000177414 "Ubiquitin conjugating enzyme E2 U" Q5VVX9 1 64203627-64267368 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 19 "testis: 44.7" "Group enriched" "Detected in some" 4 "Early spermatids: 154.3;Late spermatids: 214.5" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enhanced" "Detected in many" "midbrain: 8.1" NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 25: Spermatids - Spermatogenesis" "unprognostic (9.44e-4)" "unprognostic (5.52e-2)" "unprognostic (1.81e-1)" "unprognostic (2.37e-1)" "unprognostic (4.01e-2)" "unprognostic (3.63e-1)" "unprognostic (7.69e-2)" 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.2 0.5 0.0 0.9 0.0 0.0 0.2 0.7 0.0 0.0 0.0 0.1 0.2 0.2 0.4 0.0 0.0 0.1 0.2 0.2 0.0 0.3 0.3 0.0 0.1 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.2 0.0 2.4 44.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.2 0.5 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 1.8 0.0 0.1 0.0 0.0 0.0 1.2 154.3 0.0 0.0 0.1 0.0 0.0 0.2 0.2 2.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 214.5 1.8 0.1 0.0 0.0 0.6 0.0 0.0 0.5 0.5 0.8 0.0 0.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 40.9 2.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 UBE2W "FLJ11011, UBC-16" ENSG00000104343 "Ubiquitin conjugating enzyme E2 W" Q96B02 8 73780097-73878910 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 154.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "HPA045161, HPA073181" Uncertain Approved Nucleoli NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 23: Testis - Cell cycle regulation" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoli "HPA045161: AB_10960706, HPA073181: AB_2686578" "unprognostic (5.36e-2)" "unprognostic (1.87e-1)" "unprognostic (7.52e-2)" "unprognostic (1.32e-3)" "unprognostic (3.17e-1)" "unprognostic (9.74e-2)" "unprognostic (3.09e-2)" "unprognostic (6.93e-3)" "unprognostic (1.83e-1)" "unprognostic (3.47e-1)" "unprognostic (1.33e-1)" "unprognostic (2.34e-1)" "unprognostic (5.01e-2)" "unprognostic (4.38e-2)" "unprognostic (9.31e-2)" "unprognostic (1.62e-1)" "unprognostic (1.18e-1)" 7.5 6.2 5.3 7.5 5.3 11.4 7.0 6.3 7.2 5.9 1.1 5.2 4.5 5.1 5.5 8.7 4.7 8.1 8.3 6.1 3.0 11.2 12.6 7.3 7.1 2.8 2.1 5.4 6.7 8.6 4.6 7.3 3.4 6.0 5.9 10.4 5.7 5.2 8.5 5.5 4.7 6.3 1.6 6.7 5.5 9.5 3.3 7.0 9.1 10.0 7.1 9.7 6.2 4.2 10.3 7.0 8.2 8.0 13.0 14.4 6.8 10.8 12.6 10.6 10.8 5.9 11.1 4.8 8.6 11.7 15.7 10.0 11.2 11.7 16.7 7.7 7.2 10.3 6.5 9.0 8.9 5.6 12.9 10.6 12.2 12.4 21.9 8.5 13.4 5.6 5.1 9.7 16.1 8.7 11.8 6.4 6.2 14.3 13.0 3.8 7.5 4.1 19.7 11.6 5.6 6.5 8.5 26.4 13.2 8.4 13.4 10.0 11.8 12.2 9.4 9.7 8.2 8.7 9.5 3.6 11.2 8.2 11.2 23.8 13.1 17.4 4.7 12.8 5.8 6.8 4.8 3.6 9.1 6.8 4.3 5.0 33.1 7.0 14.4 11.9 6.1 6.9 5.3 5.3 6.3 7.2 6.1 3.0 2.8 2.1 3.4 1.6 3.3 4.2 28.7 16.0 14.0 40.1 30.3 55.3 26.4 32.1 19.4 35.5 26.7 14.7 24.3 37.1 22.9 53.3 16.7 18.4 35.0 14.2 50.9 23.2 154.5 18.3 21.0 35.3 23.3 26.5 117.0 17.4 20.0 24.9 13.3 26.9 21.0 16.8 26.0 28.7 39.9 42.1 91.8 12.1 22.4 50.3 107.9 56.8 20.5 45.7 42.7 104.9 67.0 28.8 21.6 66.9 67.7 20.9 12.4 18.8 21.3 34.1 14.7 76.1 19.2 32.2 19.7 27.3 39.9 39.4 30.4 20.9 64.5 55.1 31.0 30.6 12.9 40.9 UBE2Z "FLJ13855, USE1" ENSG00000159202 "Ubiquitin conjugating enzyme E2 Z" Q9H832 17 48908407-48929056 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007922 Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 30: Epididymis - Antimicrobial activity" "Cluster 44: HDLM-2 - Immune response" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Cytosol" "HPA007922: AB_1858551" "unprognostic (6.85e-2)" "unprognostic (5.72e-3)" "prognostic favorable (4.62e-4)" "unprognostic (9.11e-2)" "unprognostic (3.71e-3)" "unprognostic (1.76e-1)" "prognostic unfavorable (5.57e-4)" "unprognostic (2.32e-2)" "unprognostic (5.26e-2)" "unprognostic (8.66e-2)" "unprognostic (9.17e-3)" "unprognostic (3.48e-2)" "prognostic unfavorable (1.05e-4)" "unprognostic (2.63e-2)" "unprognostic (2.11e-2)" "unprognostic (1.91e-2)" "unprognostic (1.52e-1)" 33.5 45.9 37.4 37.8 40.6 33.4 36.0 37.7 44.5 41.2 32.8 37.6 34.6 39.8 60.3 45.3 44.4 34.6 33.8 40.0 40.7 40.2 33.1 34.9 44.9 39.2 37.9 36.2 34.5 46.8 31.4 42.6 42.6 39.1 40.4 38.4 38.5 47.0 29.9 43.9 35.7 49.3 35.7 41.9 35.8 28.0 40.7 45.2 50.2 28.8 59.3 45.8 39.1 57.8 101.2 122.4 45.1 43.0 111.8 107.7 61.6 107.6 131.1 126.1 120.7 153.8 84.8 81.6 150.5 133.1 158.0 64.0 57.1 100.7 159.7 271.7 61.8 73.9 80.3 96.8 128.8 53.0 76.3 92.4 109.5 103.1 132.3 134.7 94.0 38.1 55.2 103.0 137.4 160.8 57.5 52.4 42.1 122.4 105.7 45.7 114.6 46.6 98.7 97.6 46.4 70.1 73.2 38.8 76.5 100.7 107.7 41.4 111.2 187.2 89.9 62.0 89.4 77.8 79.5 47.6 91.8 38.2 83.2 5.2 7.7 5.7 8.3 9.9 6.8 6.2 7.3 8.4 5.4 8.6 6.9 7.6 7.3 5.4 9.5 6.8 8.2 6.4 37.4 40.6 37.7 44.5 40.0 40.7 39.2 37.9 42.6 35.7 40.7 57.8 36.6 25.6 19.2 17.9 32.7 52.8 50.3 47.1 27.3 56.4 40.6 32.9 37.9 21.5 25.8 36.8 41.7 34.2 40.0 42.1 21.5 44.2 1.6 48.8 40.8 44.0 48.6 23.4 22.5 54.7 32.7 35.1 20.9 59.5 6.3 37.6 37.5 25.8 24.8 43.7 20.8 35.9 20.3 28.1 54.0 5.1 28.0 35.6 30.2 12.2 48.6 31.6 26.8 13.6 52.7 75.8 25.6 29.0 23.7 89.5 34.7 27.5 42.1 34.4 32.9 25.8 39.3 21.6 26.0 35.9 57.0 42.8 30.7 50.4 30.8 66.7 UBE3A "ANCR, AS, E6-AP, EPVE6AP, FLJ26981, HPVE6A" ENSG00000114062 "Ubiquitin protein ligase E3A" Q05086 15 25333728-25439051 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Biological rhythms, Host-virus interaction, Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009723, HPA039410, HPA040380" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm Cytosol "CAB009723: AB_639982, HPA039410: AB_10671997, HPA040380: AB_2676952" "unprognostic (7.95e-2)" "unprognostic (2.61e-2)" "unprognostic (1.58e-1)" "unprognostic (2.99e-1)" "unprognostic (1.13e-1)" "unprognostic (3.55e-2)" "unprognostic (1.44e-1)" "unprognostic (3.05e-1)" "unprognostic (5.07e-2)" "unprognostic (1.69e-1)" "unprognostic (3.40e-2)" "unprognostic (4.83e-2)" "unprognostic (6.31e-2)" "unprognostic (3.08e-2)" "unprognostic (1.42e-1)" "unprognostic (1.15e-1)" "unprognostic (8.17e-2)" 29.1 29.0 28.0 27.6 30.3 32.4 32.6 42.8 41.7 33.5 14.0 33.5 22.9 32.9 29.5 32.9 29.9 24.5 40.6 31.0 28.2 32.6 42.2 24.9 33.3 22.3 23.6 37.1 27.2 38.4 15.3 28.4 24.0 31.8 28.9 32.8 23.3 28.4 109.2 26.8 29.5 30.9 19.9 26.9 26.1 45.6 28.1 41.7 41.5 92.0 34.2 32.8 20.0 29.2 55.9 33.6 77.7 46.1 45.0 56.4 38.4 84.8 54.8 59.9 55.6 76.0 27.6 103.4 61.2 68.2 57.8 51.2 106.8 62.2 75.2 54.1 32.7 85.8 49.0 43.1 65.5 107.0 60.2 60.6 56.2 58.3 71.6 60.0 47.6 87.0 89.0 71.1 95.1 32.3 84.0 29.1 50.3 62.1 46.6 88.6 117.8 45.6 51.7 91.1 80.0 59.6 72.1 72.1 102.1 51.3 57.9 56.7 59.2 102.1 84.7 52.1 64.5 77.5 103.4 139.5 60.4 56.6 55.3 14.4 12.7 17.2 17.0 11.2 19.9 17.3 18.5 20.8 16.7 22.8 20.8 18.7 2.2 29.6 22.3 15.2 15.8 9.7 28.0 30.3 42.8 41.7 31.0 28.2 22.3 23.6 24.0 19.9 28.1 29.2 56.6 96.1 80.5 112.6 74.7 71.1 83.8 40.6 84.2 82.7 59.5 42.3 175.3 42.9 58.7 38.6 56.3 52.3 74.3 43.3 19.6 51.6 139.4 53.6 75.2 58.7 68.7 64.3 187.7 49.6 49.6 64.1 52.5 63.8 62.8 84.1 44.3 58.6 46.0 80.8 196.3 55.0 12.2 60.9 41.1 61.6 56.8 64.4 53.4 87.1 53.3 54.5 54.6 126.2 124.4 59.8 41.5 64.7 95.7 102.8 51.4 50.3 59.4 59.2 78.9 119.0 80.5 146.1 88.3 78.3 90.6 74.0 63.3 65.7 52.6 98.6 UBE3B ENSG00000151148 "Ubiquitin protein ligase E3B" Q7Z3V4 12 109477402-109536705 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041012 Approved Approved "Nuclear speckles,Mitochondria" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 6: T47d - Mammary gland" "Cluster 51: Myeloid cells - Hemostasis" "Nuclear speckles" Mitochondria "HPA041012: AB_10964435" "unprognostic (1.53e-2)" "unprognostic (1.01e-1)" "unprognostic (7.12e-2)" "unprognostic (7.37e-2)" "unprognostic (7.43e-2)" "unprognostic (1.29e-1)" "unprognostic (4.92e-2)" "unprognostic (7.19e-2)" "unprognostic (2.93e-1)" "unprognostic (4.46e-3)" "unprognostic (9.39e-2)" "unprognostic (1.23e-1)" "prognostic favorable (2.49e-5)" "unprognostic (3.35e-1)" "unprognostic (3.35e-2)" "unprognostic (2.87e-1)" "unprognostic (1.26e-1)" 13.8 16.5 14.4 10.7 16.1 9.2 13.7 13.3 15.6 14.4 16.5 17.8 12.9 14.1 13.4 18.6 16.2 12.1 26.2 14.4 12.4 16.7 16.0 13.6 12.6 13.7 14.6 15.8 14.3 22.6 13.6 13.1 14.8 15.4 18.1 14.9 14.4 14.1 34.0 19.2 15.8 14.7 12.5 15.8 16.5 12.9 16.1 12.6 18.2 29.7 13.5 17.0 14.5 20.3 17.1 26.4 20.4 14.8 33.9 27.1 17.9 22.1 25.1 26.2 17.4 28.0 17.1 10.6 16.0 36.3 22.5 21.5 20.9 28.3 25.1 23.4 14.7 20.3 17.6 25.5 21.7 16.7 16.2 31.0 25.8 25.4 30.2 39.5 28.7 24.8 22.7 9.7 30.2 26.6 11.5 24.2 21.0 19.1 31.6 18.8 19.2 20.9 22.4 30.2 19.1 34.9 25.8 34.6 17.3 23.7 35.3 17.6 26.5 32.3 9.2 16.8 16.0 21.8 19.4 18.6 32.1 13.7 27.4 22.9 12.9 12.8 12.6 14.5 12.4 13.6 12.1 9.0 12.4 10.0 10.0 13.3 16.1 13.1 12.0 11.4 16.2 10.7 14.4 16.1 13.3 15.6 14.4 12.4 13.7 14.6 14.8 12.5 16.1 20.3 11.9 12.8 15.1 34.0 9.7 5.1 11.8 13.9 6.8 19.3 14.4 12.8 35.4 11.5 17.1 16.5 33.3 17.9 12.8 21.0 11.7 17.7 15.7 12.6 12.5 14.2 9.0 13.0 24.5 15.3 11.5 11.1 18.8 12.2 9.5 20.0 11.7 18.8 12.5 21.9 23.6 15.9 18.3 19.2 6.1 32.0 12.5 14.2 10.6 13.1 17.7 13.6 32.0 21.1 38.3 25.3 13.7 9.8 15.6 17.2 19.6 19.9 18.4 25.0 6.6 9.4 13.0 10.4 13.2 13.4 7.2 23.7 10.7 17.7 16.8 18.4 UBE3C "KIAA0010, KIAA10" ENSG00000009335 "Ubiquitin protein ligase E3C" Q15386 7 157138916-157269370 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039915 Approved Approved "Nucleoplasm,Plasma membrane,Mitochondria" NA NA "Cluster 35: T-regs - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 18: U-2197 - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Mitochondria" "Plasma membrane" "HPA039915: AB_10795264" "unprognostic (2.83e-2)" "unprognostic (9.27e-3)" "unprognostic (2.41e-1)" "unprognostic (2.29e-1)" "unprognostic (1.19e-2)" "unprognostic (3.14e-2)" "unprognostic (1.36e-1)" "unprognostic (7.02e-2)" "unprognostic (2.34e-2)" "unprognostic (1.58e-1)" "unprognostic (3.01e-3)" "unprognostic (8.64e-2)" "prognostic favorable (9.18e-6)" "unprognostic (9.74e-2)" "unprognostic (1.86e-1)" "unprognostic (1.87e-1)" "unprognostic (3.60e-2)" 25.7 17.4 12.0 21.5 13.2 16.2 21.7 17.5 14.1 18.4 18.8 22.3 20.0 19.4 13.4 28.3 18.5 19.1 28.5 13.2 14.1 20.3 22.9 19.0 20.9 14.6 13.4 20.0 22.4 36.2 11.1 17.5 14.9 19.9 23.2 20.2 22.7 22.7 65.6 20.8 20.8 29.2 12.7 18.0 20.9 26.2 14.8 18.6 17.3 58.5 22.8 28.1 17.0 15.0 68.8 53.3 33.5 67.3 58.8 61.3 37.1 74.0 63.4 61.1 61.3 48.3 55.7 36.8 64.0 82.1 79.6 42.4 52.6 68.3 72.0 67.6 48.3 37.6 35.6 35.0 58.4 56.9 52.8 54.8 61.6 68.0 55.9 46.4 72.2 30.3 55.7 39.9 87.6 59.8 56.2 35.9 53.3 61.1 63.6 31.9 37.7 75.9 63.2 74.1 53.5 55.2 72.8 61.9 54.5 37.2 32.0 39.3 65.3 76.6 16.5 190.0 93.3 39.7 42.9 37.0 87.7 83.0 89.5 0.3 1.8 1.1 2.2 2.3 3.0 1.1 2.4 2.4 2.0 1.2 2.2 2.7 0.6 2.1 2.5 1.8 2.8 1.5 12.0 13.2 17.5 14.1 13.2 14.1 14.6 13.4 14.9 12.7 14.8 15.0 23.8 22.4 19.7 52.2 14.2 27.5 17.3 19.0 17.6 34.7 22.4 16.9 33.7 22.8 14.2 25.8 66.7 14.9 25.3 27.3 9.8 20.3 11.6 21.6 27.4 23.4 24.5 14.9 98.9 17.7 17.4 19.6 27.0 24.5 9.5 23.0 23.6 48.3 15.4 32.0 100.7 21.8 12.2 27.6 15.2 10.1 15.5 20.6 5.4 52.5 22.0 9.9 26.8 81.4 96.2 27.5 13.4 25.6 17.5 31.5 20.6 19.1 19.8 39.9 0.0 23.1 21.4 26.6 27.3 37.5 33.2 15.1 20.9 22.3 26.2 28.1 UBE4A "E4, KIAA0126, UBOX2, UFD2" ENSG00000110344 "Ubiquitination factor E4A" Q14139 11 118359600-118399211 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA055035, HPA064010" Approved Supported "Nuclear speckles" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 1: K-562 - Erythropoiesis" "Cluster 59: Non-specific - Transcription" "Nuclear speckles" "HPA055035: AB_2682679, HPA064010: AB_2685174" "unprognostic (1.32e-2)" "unprognostic (8.15e-2)" "unprognostic (5.23e-3)" "unprognostic (3.34e-1)" "unprognostic (2.80e-2)" "unprognostic (1.97e-1)" "unprognostic (7.67e-3)" "unprognostic (3.31e-1)" "unprognostic (1.30e-1)" "unprognostic (4.67e-2)" "unprognostic (6.01e-2)" "unprognostic (5.83e-2)" "unprognostic (7.73e-3)" "unprognostic (4.74e-2)" "unprognostic (5.94e-2)" "unprognostic (2.72e-1)" "unprognostic (8.86e-2)" 18.6 14.1 15.9 20.3 17.8 17.7 18.0 25.5 20.5 16.1 15.7 17.4 19.1 18.9 18.6 15.0 15.5 15.6 19.7 15.1 20.2 18.0 27.6 17.0 22.5 18.9 18.1 19.1 19.5 19.0 9.5 17.5 20.2 19.0 20.7 18.4 16.1 14.9 22.1 24.0 20.5 18.1 16.5 19.7 23.9 17.7 19.7 21.3 18.4 15.9 21.6 14.7 12.7 24.4 18.8 17.9 22.4 22.5 38.0 34.9 22.3 27.1 28.1 19.7 24.0 49.7 44.9 39.3 51.0 34.4 26.5 40.3 31.9 25.7 32.6 22.3 14.8 64.5 15.4 25.7 32.6 36.8 47.3 35.4 18.2 40.4 39.3 26.3 33.3 33.9 37.2 35.9 28.7 35.4 31.5 36.5 20.9 37.7 22.7 20.0 32.5 40.2 21.6 43.1 20.3 21.1 39.2 33.5 12.3 24.2 44.8 16.6 34.6 29.0 19.0 25.1 22.8 10.5 13.8 36.4 16.1 41.6 30.4 14.2 9.5 9.7 7.5 10.5 5.8 5.1 5.6 5.4 9.8 3.5 6.0 5.4 9.6 6.5 12.8 5.7 7.0 4.8 15.9 17.8 25.5 20.5 15.1 20.2 18.9 18.1 20.2 16.5 19.7 24.4 28.7 12.8 31.9 45.7 27.5 26.8 22.0 20.4 25.6 19.5 26.3 18.0 18.2 10.0 27.8 14.7 18.8 20.3 30.6 25.5 5.9 19.8 18.0 23.7 35.3 20.9 18.6 26.9 46.2 28.5 19.8 24.2 41.8 31.7 10.8 25.7 19.2 44.6 21.9 16.8 56.3 20.1 30.5 27.9 23.1 15.2 17.1 33.2 24.9 36.5 32.4 20.5 24.7 55.8 80.9 27.0 18.3 21.4 42.0 23.1 29.0 11.5 37.5 16.8 19.7 23.4 23.6 35.3 22.0 30.3 39.2 24.8 31.0 26.0 20.3 26.1 UBE4B "E4, KIAA0684, UBOX3, UFD2" ENSG00000130939 "Ubiquitination factor E4B" O95155 1 10032832-10181239 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 99.9;Inhibitory neurons: 101.1;Oligodendrocytes: 185.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019219 Approved NA NA "Cluster 13: T-cells - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA019219: AB_1858554" "unprognostic (5.32e-2)" "unprognostic (1.56e-1)" "unprognostic (3.74e-2)" "unprognostic (5.46e-2)" "unprognostic (7.19e-2)" "unprognostic (4.39e-2)" "prognostic unfavorable (3.69e-5)" "unprognostic (2.53e-1)" "unprognostic (9.72e-2)" "unprognostic (1.12e-1)" "unprognostic (4.26e-1)" "unprognostic (3.10e-1)" "unprognostic (1.86e-3)" "unprognostic (2.99e-1)" "unprognostic (3.99e-1)" "unprognostic (1.35e-1)" "unprognostic (1.76e-3)" 13.5 22.2 13.0 12.9 18.4 20.1 13.4 19.6 16.7 15.8 9.3 24.3 16.2 19.4 12.6 22.8 14.6 12.3 23.2 13.6 13.9 13.6 13.9 11.2 12.4 19.1 15.1 23.3 26.9 21.1 15.2 20.0 20.7 14.1 13.4 19.3 15.0 12.8 41.8 25.3 15.9 17.4 10.4 12.2 20.4 9.5 16.6 17.1 21.0 27.5 14.2 17.3 16.7 28.7 37.9 24.5 28.8 31.6 37.5 49.0 22.5 24.4 31.1 24.0 24.3 26.6 43.2 32.4 29.2 43.6 18.6 27.5 37.2 28.2 28.1 33.8 20.8 35.1 41.5 30.2 27.4 36.6 23.9 40.4 24.7 32.1 26.8 43.9 35.0 23.3 61.7 42.4 22.0 19.6 24.1 16.7 38.2 24.2 19.9 23.6 28.1 34.8 23.0 17.0 35.0 26.7 38.8 26.8 49.5 30.4 21.1 26.0 30.4 21.1 32.0 26.5 20.2 18.8 27.7 37.1 30.9 41.4 28.4 3.4 4.9 2.4 3.0 3.7 5.1 3.6 5.0 5.0 4.1 3.2 4.5 3.6 5.5 1.8 2.8 1.8 6.4 3.6 13.0 18.4 19.6 16.7 13.6 13.9 19.1 15.1 20.7 10.4 16.6 28.7 13.5 22.4 24.0 65.6 17.7 17.6 14.6 13.0 21.6 14.7 18.6 13.2 42.2 15.7 12.9 9.2 25.0 33.1 12.3 12.0 9.8 12.8 3.0 22.4 23.3 15.4 16.3 33.4 99.9 14.8 13.5 18.5 14.8 24.6 6.3 27.9 17.2 16.4 16.5 16.8 101.1 16.2 16.2 22.1 10.9 4.8 11.1 16.1 5.4 46.9 22.9 10.5 19.6 82.4 185.2 19.5 19.5 8.6 24.3 19.3 25.5 10.3 12.9 33.5 19.7 15.2 16.4 8.5 15.0 35.8 22.4 20.5 18.3 21.1 18.6 18.5 UBLCP1 "CPUB1, MGC10067" ENSG00000164332 "Ubiquitin like domain containing CTD phosphatase 1" Q8WVY7 5 159263290-159286036 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039615 Approved Supported "Nucleoplasm,Nucleoli,Nucleoli rim" NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 16: Immune cells - Immune response" "Cluster 30: Epithelial cell lines - Translation" "Cluster 59: Non-specific - Transcription" "Nucleoplasm, Nucleoli, Nucleoli rim" "HPA039615: AB_10674425" "unprognostic (1.25e-1)" "unprognostic (3.10e-1)" "unprognostic (6.04e-3)" "unprognostic (3.45e-2)" "unprognostic (7.08e-2)" "unprognostic (6.82e-2)" "prognostic unfavorable (4.46e-5)" "unprognostic (4.01e-1)" "unprognostic (2.14e-2)" "unprognostic (1.98e-1)" "unprognostic (1.91e-2)" "unprognostic (5.43e-2)" "unprognostic (1.16e-1)" "unprognostic (1.87e-1)" "unprognostic (1.18e-1)" "unprognostic (6.39e-2)" "unprognostic (2.51e-2)" 19.0 16.3 8.8 24.5 9.4 23.3 20.5 9.6 14.1 19.9 6.4 15.7 12.6 23.6 17.2 21.1 15.1 17.1 16.4 10.0 10.5 19.2 18.3 22.4 33.7 10.3 9.5 15.8 14.9 19.7 5.6 23.6 10.2 17.5 16.9 18.2 14.2 19.6 10.9 15.5 12.7 22.8 9.6 26.7 15.8 30.5 10.7 36.4 16.6 13.8 37.3 21.3 11.7 10.7 39.9 28.6 57.9 64.1 58.9 54.5 34.1 42.5 64.6 42.8 56.6 23.5 27.1 35.7 46.1 53.7 60.9 29.7 36.3 81.8 74.3 71.3 35.7 27.3 23.8 21.9 74.0 62.7 41.1 48.1 76.8 38.9 77.2 34.0 41.4 36.4 38.4 47.0 60.8 12.9 33.5 22.9 41.7 20.0 17.1 42.3 56.5 42.8 44.4 30.4 30.4 42.9 42.7 29.0 115.8 34.6 30.2 45.6 44.2 44.0 37.8 22.8 54.9 36.9 39.8 53.5 46.1 43.9 66.1 47.6 10.8 27.5 25.5 22.4 28.4 18.5 23.9 26.7 14.2 16.7 26.9 29.1 30.8 42.8 24.5 17.8 28.3 13.6 8.8 9.4 9.6 14.1 10.0 10.5 10.3 9.5 10.2 9.6 10.7 10.7 31.9 12.8 41.6 12.7 43.0 15.9 10.3 43.0 35.3 12.7 22.5 14.4 16.8 10.0 34.4 14.7 4.2 31.8 36.8 13.2 35.2 23.0 8.5 23.2 32.1 24.2 10.7 30.1 26.3 24.9 18.7 27.1 29.6 17.4 45.0 16.9 28.5 15.6 39.0 20.2 25.0 14.6 18.3 40.0 16.4 4.2 20.5 33.1 17.8 14.0 30.9 17.6 32.0 22.6 25.6 22.5 10.1 24.8 39.3 13.2 8.8 34.5 37.4 13.1 19.7 18.8 26.2 74.0 61.5 51.8 20.6 17.8 40.8 30.7 14.5 10.1 UBR1 ENSG00000159459 "Ubiquitin protein ligase E3 component n-recognin 1" Q8IWV7 15 42942897-43106113 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 48.6" "Cell type enhanced" "Detected in many" "Excitatory neurons: 108.9;Inhibitory neurons: 108.8;Oligodendrocyte precursor cells: 102.1;Oligodendrocytes: 127.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038838, HPA038839" Approved Approved Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" Vesicles "Nucleoplasm, Cytosol" "HPA038838: AB_10673120, HPA038839: " "unprognostic (1.07e-2)" "unprognostic (5.02e-2)" "unprognostic (9.77e-2)" "unprognostic (1.55e-2)" "unprognostic (1.89e-2)" "unprognostic (1.29e-1)" "unprognostic (2.67e-1)" "unprognostic (1.49e-1)" "unprognostic (4.79e-1)" "unprognostic (2.97e-2)" "unprognostic (1.93e-2)" "unprognostic (1.79e-1)" "unprognostic (1.27e-3)" "unprognostic (5.78e-2)" "unprognostic (1.52e-1)" "unprognostic (2.00e-1)" "unprognostic (1.89e-1)" 9.1 7.9 12.5 8.8 29.4 24.9 9.3 11.7 17.4 9.9 4.8 8.6 7.8 10.7 7.4 5.8 8.0 8.6 13.7 11.6 31.5 9.2 7.1 8.6 10.9 24.2 18.3 7.7 9.5 14.3 6.6 10.5 21.6 10.0 8.0 14.3 6.3 10.5 12.0 5.6 7.8 9.6 8.5 9.5 7.2 10.1 21.2 13.3 12.6 14.0 8.7 9.1 5.8 48.6 7.4 10.2 11.6 9.6 17.1 14.7 10.7 17.6 19.4 15.9 19.2 13.3 5.5 8.6 10.1 18.4 18.9 12.4 17.1 15.5 18.1 18.0 8.4 33.1 20.4 6.3 12.3 23.0 14.4 15.3 8.4 18.8 14.8 14.6 17.0 16.7 19.6 12.3 18.7 4.5 12.7 6.8 6.5 18.9 10.6 16.4 15.7 6.4 14.9 16.6 12.0 10.3 22.7 12.0 7.7 13.1 10.9 12.2 24.3 17.9 11.1 16.7 18.0 14.6 26.4 23.6 12.2 14.6 16.6 3.7 1.5 2.5 2.4 1.8 2.9 1.9 2.6 2.9 1.4 2.3 2.6 3.2 2.9 3.2 1.7 2.2 1.9 0.9 12.5 29.4 11.7 17.4 11.6 31.5 24.2 18.3 21.6 8.5 21.2 48.6 46.4 48.1 30.7 73.1 28.9 10.6 11.6 9.3 17.1 27.5 15.4 10.8 28.0 12.8 19.1 9.2 27.1 14.7 35.8 12.8 0.0 10.8 16.8 13.4 27.4 24.5 14.4 23.8 108.9 14.4 7.7 25.6 20.9 18.2 28.5 22.8 17.2 9.9 8.1 32.0 108.8 10.9 14.2 16.4 10.6 16.9 16.1 17.1 8.8 73.1 15.6 13.5 23.7 102.1 127.6 10.3 8.2 20.7 33.2 7.7 12.3 9.2 15.7 38.8 13.1 34.7 36.5 27.0 17.8 8.6 7.2 36.9 31.4 16.5 10.6 9.8 UBR2 "bA49A4.1, C6orf133, dJ392M17.3, KIAA0349" ENSG00000024048 "Ubiquitin protein ligase E3 component n-recognin 2" Q8IWV8 6 42564029-42693505 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 138.5;Inhibitory neurons: 142.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 38.5" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027869, HPA027880" Approved Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 21: OE19 - Mitochondria" "Cluster 6: Erythroid cells - Oxygen transport" Nucleoplasm "Plasma membrane" "HPA027869: AB_10600416, HPA027880: AB_10601217" "unprognostic (3.26e-1)" "unprognostic (1.29e-1)" "unprognostic (8.33e-2)" "unprognostic (2.95e-2)" "unprognostic (1.08e-2)" "unprognostic (4.23e-2)" "unprognostic (1.32e-1)" "unprognostic (7.24e-2)" "unprognostic (5.05e-2)" "prognostic favorable (1.65e-4)" "unprognostic (1.12e-1)" "unprognostic (7.53e-2)" "unprognostic (1.30e-2)" "unprognostic (3.88e-1)" "unprognostic (1.81e-1)" "unprognostic (5.78e-2)" "unprognostic (7.77e-3)" 11.0 10.7 8.5 12.7 10.1 17.9 12.9 14.1 11.1 10.3 11.3 12.7 14.4 10.9 11.2 9.5 9.4 8.6 11.2 9.0 8.8 12.1 17.2 11.9 12.7 9.0 8.7 12.2 15.6 15.0 8.8 11.7 9.3 10.5 13.8 29.7 12.0 10.0 22.8 12.2 13.8 10.6 8.6 15.3 12.2 6.2 9.1 13.5 13.3 22.3 11.5 10.8 10.4 14.2 18.5 9.0 10.4 16.4 20.9 20.0 14.0 13.8 14.9 12.0 12.4 13.2 7.4 12.5 10.7 15.0 13.9 18.1 15.1 11.8 15.2 17.1 10.6 20.0 13.3 17.3 17.0 19.6 13.1 14.1 12.7 12.0 12.9 14.8 13.7 17.9 23.7 15.4 11.7 14.9 15.4 17.1 9.5 36.2 8.7 13.6 15.5 19.0 13.8 15.7 12.4 9.8 14.0 13.3 13.9 15.7 13.0 18.7 19.8 10.8 8.4 13.5 10.1 14.1 13.4 18.9 5.7 14.5 6.8 17.7 7.1 15.2 6.5 7.3 5.4 5.2 4.2 5.1 5.5 5.2 4.3 4.8 38.5 5.9 9.8 4.1 5.3 3.4 8.5 10.1 14.1 11.1 9.0 8.8 9.0 8.7 9.3 8.6 9.1 14.2 33.5 16.0 24.6 82.6 33.9 16.6 18.1 14.9 28.5 43.0 20.4 15.9 39.3 30.0 22.1 20.2 60.5 17.4 46.6 51.6 17.6 18.5 12.4 27.5 30.8 24.8 12.6 75.1 138.5 15.3 13.4 26.5 34.1 32.9 20.3 31.3 21.8 35.0 13.2 63.9 142.7 22.5 14.2 26.7 28.6 3.9 25.4 26.1 19.6 87.1 43.0 23.5 32.0 123.1 131.4 15.0 29.1 24.0 50.6 22.8 37.2 11.7 27.9 53.5 39.5 30.0 27.2 11.2 10.9 28.1 16.2 17.2 44.0 24.0 21.5 22.7 UBR3 "DKFZp434P117, FLJ37422, KIAA2024, ZNF650" ENSG00000144357 "Ubiquitin protein ligase E3 component n-recognin 3" Q6ZT12 2 169827454-170084131 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 71.2;tongue: 87.1" "Cell type enhanced" "Detected in all" "Astrocytes: 162.6;Excitatory neurons: 305.1;Inhibitory neurons: 302.0;Oligodendrocyte precursor cells: 232.2;Oligodendrocytes: 288.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA035390 Approved Approved Nucleoplasm,Nucleoli NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 36: HEL - Hemostasis" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Nucleoplasm, Nucleoli" "HPA035390: AB_10670699" "unprognostic (1.35e-2)" "unprognostic (1.24e-1)" "unprognostic (1.59e-2)" "unprognostic (1.27e-1)" "unprognostic (2.07e-2)" "unprognostic (1.24e-1)" "unprognostic (1.00e-1)" "unprognostic (3.91e-2)" "unprognostic (1.05e-1)" "unprognostic (1.24e-1)" "unprognostic (1.76e-1)" "unprognostic (1.26e-1)" "unprognostic (3.19e-2)" "unprognostic (5.56e-2)" "unprognostic (2.01e-1)" "unprognostic (3.38e-1)" "unprognostic (2.18e-1)" 14.2 12.4 4.4 7.7 5.8 7.4 9.2 5.9 8.5 10.9 2.8 8.8 8.1 10.1 6.9 12.8 8.4 9.3 29.4 8.0 3.3 15.2 21.0 8.8 7.2 2.4 2.7 10.2 11.9 21.5 2.1 8.7 3.3 13.1 8.5 21.2 11.5 10.3 71.2 9.2 7.5 11.1 3.2 8.8 9.3 9.7 3.4 9.5 17.9 87.1 7.3 11.0 2.3 8.4 14.8 12.4 12.9 17.1 25.0 19.7 10.8 26.1 15.0 14.7 11.8 19.1 9.1 16.7 22.2 20.5 12.0 19.0 15.5 13.2 18.2 17.4 13.4 61.1 12.6 20.3 12.4 20.4 18.9 11.9 12.1 19.3 12.9 11.7 14.8 8.3 32.4 17.6 25.6 14.0 13.3 10.0 10.1 14.9 10.2 12.6 21.1 17.8 10.5 20.5 25.1 13.7 18.4 16.7 10.6 10.2 10.9 11.4 18.9 22.1 9.0 17.5 16.7 14.2 11.9 15.1 18.2 11.8 12.5 0.0 0.6 0.5 0.9 0.6 1.3 0.6 0.5 0.8 0.9 0.3 0.9 1.2 0.6 0.8 0.5 0.7 1.0 0.4 4.4 5.8 5.9 8.5 8.0 3.3 2.4 2.7 3.3 3.2 3.4 8.4 19.0 44.8 26.9 162.6 16.3 25.9 12.4 14.8 20.5 46.3 15.8 8.9 109.7 17.2 20.0 12.9 81.3 19.7 22.9 17.1 3.9 8.7 7.6 16.8 21.9 26.4 16.7 24.4 305.1 11.0 8.4 22.2 23.4 22.0 16.5 22.7 30.4 39.0 10.2 63.9 302.0 11.3 22.4 20.9 18.7 10.2 25.7 18.7 16.0 110.5 18.7 61.7 14.4 232.2 288.0 10.7 15.0 19.2 21.3 20.9 15.3 10.0 13.4 51.5 26.3 29.0 21.8 12.4 8.6 22.9 29.0 23.0 18.1 17.3 13.2 17.2 UBR4 "KIAA0462, KIAA1307, RBAF600, ZUBR1" ENSG00000127481 "Ubiquitin protein ligase E3 component n-recognin 4" Q5T4S7 1 19074510-19210266 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Host-virus interaction, Ubl conjugation pathway" "Calmodulin-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Basal keratinocytes: 271.0;Suprabasal keratinocytes: 252.9;Urothelial cells: 236.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 39.8" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA013394, HPA021046" Approved Supported Nucleoplasm,Centrosome,Cytosol NA NA 15000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 31: Skin - Epidermis development" "Cluster 21: OE19 - Mitochondria" "Cluster 22: Epithelial cell types - Mixed function" Nucleoplasm "Centrosome, Cytosol" "HPA013394: , HPA021046: AB_1858578" "unprognostic (1.37e-1)" "unprognostic (2.57e-2)" "unprognostic (2.82e-2)" "unprognostic (2.02e-1)" "unprognostic (8.78e-2)" "unprognostic (9.77e-2)" "unprognostic (1.14e-3)" "unprognostic (3.09e-1)" "unprognostic (1.96e-1)" "unprognostic (9.14e-3)" "unprognostic (7.48e-2)" "unprognostic (2.53e-1)" "unprognostic (7.68e-3)" "unprognostic (4.30e-1)" "unprognostic (1.19e-1)" "unprognostic (5.58e-2)" "unprognostic (1.52e-1)" 56.2 62.8 48.2 23.0 46.0 79.8 49.8 38.7 48.4 57.4 47.6 69.6 20.9 61.7 35.7 55.4 52.3 29.6 58.7 45.8 46.0 74.7 82.7 71.9 25.7 51.5 46.4 75.3 53.5 35.5 70.7 27.5 54.9 67.2 22.7 44.6 48.0 27.0 129.1 161.9 59.7 26.0 35.2 62.8 70.6 105.3 45.9 34.6 56.5 45.0 25.7 90.0 59.2 44.7 61.4 60.7 53.5 39.7 97.6 50.0 46.2 46.5 48.8 49.5 44.7 97.2 51.3 36.6 42.3 61.7 43.3 40.8 42.3 46.3 46.0 30.6 37.5 83.8 63.3 64.1 68.6 51.9 53.4 45.0 57.9 100.8 96.3 48.1 54.9 63.7 58.5 32.9 47.6 43.6 24.7 62.9 43.5 124.3 33.6 34.0 41.7 31.0 44.7 35.2 37.7 37.4 55.0 31.1 39.9 48.6 21.7 40.4 85.9 57.4 36.1 69.0 52.8 38.8 25.2 41.5 39.3 79.3 50.3 39.8 28.7 4.7 4.9 5.9 4.2 7.4 4.4 2.9 14.2 4.0 3.9 3.7 15.4 4.4 2.1 6.5 3.4 8.3 48.2 46.0 38.7 48.4 45.8 46.0 51.5 46.4 54.9 35.2 45.9 44.7 28.1 35.3 37.6 85.5 30.3 271.0 124.6 28.9 28.5 57.5 22.1 23.9 19.1 37.1 30.4 31.3 152.2 24.7 34.2 31.6 13.7 41.3 21.4 39.8 32.0 30.8 17.5 48.4 58.9 40.9 17.0 32.2 44.9 50.4 19.6 32.9 31.1 94.1 63.2 79.1 61.8 29.2 12.2 43.0 48.7 28.7 30.7 46.4 49.8 34.7 64.4 28.8 21.6 51.8 44.5 61.0 16.7 35.7 26.4 59.1 57.9 135.6 39.1 48.5 19.7 28.3 30.1 44.8 21.0 28.0 252.9 33.9 32.7 34.5 20.1 236.5 UBR5 "DD5, EDD, EDD1, HYD, KIAA0896" ENSG00000104517 "Ubiquitin protein ligase E3 component n-recognin 5" O95071 8 102252273-102412759 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Host-virus interaction, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 239.9;Excitatory neurons: 214.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA053688 Supported Nucleoplasm,Cytosol NA NA "Cluster 35: T-regs - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 44: Endometrium - Transcription" Nucleoplasm Cytosol "HPA053688: AB_2682230" "unprognostic (3.79e-3)" "unprognostic (7.44e-3)" "unprognostic (1.25e-1)" "unprognostic (2.10e-2)" "unprognostic (2.44e-2)" "unprognostic (1.41e-1)" "prognostic unfavorable (1.26e-4)" "unprognostic (2.50e-1)" "unprognostic (1.75e-2)" "unprognostic (7.54e-3)" "unprognostic (8.29e-3)" "unprognostic (3.84e-2)" "unprognostic (6.64e-2)" "unprognostic (3.16e-1)" "unprognostic (1.94e-1)" "unprognostic (1.69e-2)" "unprognostic (2.45e-1)" 33.0 18.3 16.6 22.4 19.4 36.5 30.9 26.5 24.0 25.6 23.4 33.3 14.9 29.6 23.7 27.5 26.1 17.3 25.8 17.3 16.0 17.5 17.7 29.8 33.6 16.0 16.1 32.2 25.7 30.4 24.4 17.8 15.7 20.0 17.0 45.4 26.1 20.7 50.1 35.6 27.2 17.2 13.7 24.2 25.0 43.9 16.6 43.0 21.0 29.6 28.6 28.2 26.4 18.9 64.5 28.4 53.2 27.5 51.8 52.2 48.9 47.4 41.9 36.6 31.7 28.3 42.1 127.1 39.8 44.5 23.7 38.2 46.2 41.1 51.1 55.3 22.7 106.5 39.7 52.2 46.1 33.7 56.3 60.1 40.4 37.5 64.5 41.5 44.6 35.6 52.3 70.2 34.8 58.0 85.3 40.3 40.1 61.8 31.6 49.3 31.6 60.9 33.5 62.3 39.1 32.5 33.4 31.8 34.3 46.1 51.4 35.1 44.6 38.5 44.9 35.1 33.5 37.3 38.7 129.5 38.0 51.2 32.0 1.8 1.5 2.4 2.4 1.5 2.4 2.1 2.5 2.5 1.8 1.7 2.0 3.0 3.0 1.1 2.7 1.6 3.4 1.0 16.6 19.4 26.5 24.0 17.3 16.0 16.0 16.1 15.7 13.7 16.6 18.9 51.4 25.6 31.7 239.9 44.8 52.3 41.2 26.3 55.8 52.0 37.3 29.6 39.8 8.6 49.9 31.3 68.8 27.7 36.2 20.9 9.8 18.8 38.6 47.5 47.0 40.1 33.4 33.2 214.2 15.0 18.9 43.7 37.8 69.0 29.8 64.3 22.9 19.0 17.0 57.2 191.7 19.5 26.4 31.4 52.6 23.6 39.7 43.7 44.4 129.3 43.5 31.3 26.8 196.6 174.0 21.4 18.3 36.5 65.9 45.2 18.3 9.0 46.5 44.8 13.1 66.3 48.4 59.4 30.2 46.8 61.1 69.6 46.9 30.8 19.5 53.5 UBR7 C14orf130 ENSG00000012963 "Ubiquitin protein ligase E3 component n-recognin 7" Q8N806 14 93207241-93229215 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 8 "Early spermatids: 300.9;Late spermatids: 372.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000861 Approved Approved Nucleoplasm NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 63: T-cells - Adaptive immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 34: Spermatids - Unknown function" Nucleoplasm "HPA000861: AB_1078321" "unprognostic (9.60e-2)" "unprognostic (5.12e-3)" "unprognostic (1.11e-1)" "unprognostic (9.20e-2)" "unprognostic (3.30e-1)" "unprognostic (2.12e-1)" "prognostic unfavorable (8.12e-5)" "unprognostic (1.14e-1)" "unprognostic (9.83e-2)" "unprognostic (1.04e-2)" "unprognostic (4.30e-2)" "unprognostic (5.94e-2)" "prognostic favorable (9.76e-5)" "unprognostic (3.61e-2)" "unprognostic (2.91e-1)" "unprognostic (2.86e-1)" "unprognostic (1.78e-1)" 12.7 10.4 16.9 13.2 19.1 21.1 19.1 16.3 20.2 17.6 17.7 16.9 11.8 14.4 14.0 13.0 14.4 13.1 22.0 18.8 15.9 16.6 15.1 12.7 22.2 15.3 16.1 17.6 22.9 25.7 8.9 10.3 16.0 14.6 18.3 24.3 12.7 15.3 17.5 15.7 13.2 15.3 17.1 14.1 14.2 19.0 17.3 34.0 16.8 25.9 27.3 13.6 10.9 18.8 26.1 33.0 52.2 44.2 24.2 24.0 18.6 54.0 38.6 57.1 43.9 23.5 28.2 60.9 42.6 28.3 26.0 30.7 55.8 30.1 60.7 46.4 29.2 45.7 33.1 23.7 11.2 65.7 47.5 15.5 20.7 33.8 21.2 21.7 33.1 54.8 41.5 60.5 57.7 77.3 104.5 35.7 24.1 69.4 61.9 81.9 92.9 33.6 20.6 42.0 65.3 45.4 39.5 32.1 16.3 31.1 58.4 44.6 24.0 43.1 23.0 37.0 56.3 69.0 103.4 61.1 37.0 49.8 38.7 34.5 11.3 18.2 17.8 14.2 19.5 26.4 16.4 16.4 11.4 20.4 13.6 15.1 16.6 18.1 18.3 15.0 26.7 13.4 16.9 19.1 16.3 20.2 18.8 15.9 15.3 16.1 16.0 17.1 17.3 18.8 13.8 16.0 6.4 9.4 16.1 19.9 8.3 8.0 6.8 6.1 11.6 11.0 19.7 11.5 8.5 11.0 10.4 12.3 15.1 15.6 11.7 9.9 300.9 8.2 8.5 11.0 5.4 20.2 16.3 12.9 15.2 12.0 9.7 9.1 5.1 8.8 12.8 11.3 14.0 3.3 12.7 8.4 12.2 10.7 10.9 372.2 9.3 9.0 14.2 7.5 9.3 13.5 13.4 10.6 13.9 8.9 5.4 12.4 26.0 4.7 10.3 9.3 5.5 13.9 6.6 11.2 10.1 38.7 23.2 10.7 13.5 6.6 12.4 6.2 12.4 6.0 UGT1A1 "GNT1, UGT1, UGT1A" ENSG00000241635 "UDP glucuronosyltransferase family 1 member A1" P22309 2 233760270-233773300 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 26 "intestine: 201.2;liver: 322.4" "Cell type enriched" "Detected in some" 7 "Hepatocytes: 105.0" "Cancer enriched" "Detected in some" 19 "liver cancer: 16.4" "Low region specificity" "Detected in single" "Immune cell enhanced" "Detected in single" "neutrophil: 1.4" "Lineage enriched" "Detected in single" 4 "granulocytes: 1.4" "Cell line enhanced" "Detected in some" "HaCaT: 14.0;OE19: 64.5;RT4: 34.7" "Not detected" "Not detected" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 2: Hepatocytes - Metabolism" "unprognostic (7.28e-2)" "unprognostic (2.49e-2)" "unprognostic (3.60e-1)" "unprognostic (5.69e-2)" "unprognostic (4.17e-3)" "unprognostic (6.31e-3)" "unprognostic (1.94e-5)" "unprognostic (2.78e-3)" "unprognostic (2.99e-4)" 0.1 0.1 0.6 0.2 0.5 0.5 0.2 1.5 0.8 0.1 0.2 3.0 201.2 0.2 0.4 3.5 0.1 1.0 0.2 0.4 0.8 4.0 322.4 0.2 0.3 0.2 0.2 0.2 0.1 0.1 0.0 0.1 0.2 0.2 2.4 0.9 0.5 0.3 0.1 1.8 79.2 0.1 0.0 0.2 2.4 0.6 0.3 0.1 0.2 0.1 0.3 10.0 0.9 0.6 0.3 1.1 0.2 0.2 0.1 0.1 0.6 0.0 0.0 0.0 0.1 5.4 0.3 0.2 2.5 0.1 0.1 14.0 0.0 0.2 0.0 0.2 0.1 0.1 0.6 1.6 0.0 0.5 0.2 0.2 0.6 0.0 0.0 0.1 0.0 0.3 0.2 0.6 0.0 0.8 0.1 0.3 0.5 64.5 6.5 0.1 0.1 0.6 0.0 34.7 0.2 0.4 2.6 0.4 0.0 0.2 0.2 0.0 0.1 0.2 0.1 0.3 0.0 0.2 0.2 0.1 0.7 0.4 0.2 0.9 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.2 0.1 0.1 1.4 0.3 0.1 0.1 0.1 0.0 0.6 0.5 1.5 0.8 0.4 0.8 0.2 0.2 0.2 0.0 0.3 0.6 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.1 0.6 0.0 0.0 0.0 0.0 0.0 3.7 1.8 0.0 0.0 0.0 1.8 0.0 0.1 2.9 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 1.1 105.0 0.0 0.0 0.0 0.4 0.0 2.4 0.0 1.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 1.6 0.0 0.1 6.9 14.6 2.2 1.5 0.0 0.0 0.4 0.1 0.2 0.1 1.5 0.0 0.0 0.1 0.0 0.7 7.3 UGT1A10 UGT1J ENSG00000242515 "UDP glucuronosyltransferase family 1 member A10" Q9HAW8 2 233636454-233773305 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "gallbladder: 22.0;intestine: 79.5;stomach 1: 32.7" "Cell type enhanced" "Detected in some" "Distal enterocytes: 1.8;Gastric mucus-secreting cells: 3.6;Intestinal goblet cells: 1.0;Paneth cells: 1.4;Proximal enterocytes: 3.9;Squamous epithelial cells: 4.3" "Cancer enhanced" "Detected in many" "urothelial cancer: 9.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 143 "RT4: 523.3" "Intracellular and membrane" NA NA "Cluster 9: Intestine - Unknown function" "Cluster 15: RT4 - Unknown function" "Cluster 45: Enterocytes - Digestion" "unprognostic (9.33e-2)" "unprognostic (7.64e-2)" "unprognostic (2.45e-3)" "unprognostic (1.73e-1)" "prognostic unfavorable (4.55e-4)" "unprognostic (1.49e-10)" "unprognostic (2.90e-1)" "unprognostic (1.50e-1)" "unprognostic (3.59e-3)" 0.1 0.0 0.0 3.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 49.5 79.5 0.1 0.0 14.6 0.0 22.0 0.0 0.0 0.0 0.4 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 36.5 0.0 0.9 0.0 0.0 0.9 53.1 1.9 0.0 0.0 32.7 1.5 0.0 0.0 0.0 0.0 0.3 1.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.3 1.4 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 523.3 0.0 0.1 3.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.6 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.0 0.3 0.3 UGT1A4 "HUG-BR2, UGT1D" ENSG00000244474 "UDP glucuronosyltransferase family 1 member A4" P22310 2 233718736-233773300 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 68 "liver: 391.7" "Cell type enriched" "Detected in some" 6 "Hepatocytes: 15.1" "Cancer enriched" "Detected in single" 487 "liver cancer: 24.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 2: Hepatocytes - Metabolism" "unprognostic (9.89e-3)" "unprognostic (6.77e-5)" "unprognostic (2.59e-1)" "unprognostic (3.50e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.7 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 391.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT1A6 "GNT1, HLUGP, UGT1F" ENSG00000167165 "UDP glucuronosyltransferase family 1 member A6" P19224 2 233691607-233773300 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "kidney: 71.3;liver: 143.3;urinary bladder: 88.8" "Cell type enhanced" "Detected in some" "Basal squamous epithelial cells: 12.5;Early spermatids: 52.4;Gastric mucus-secreting cells: 14.3;Late spermatids: 23.3;Squamous epithelial cells: 17.3" "Group enriched" "Detected in many" 5 "liver cancer: 7.2;lung cancer: 3.1;renal cancer: 7.6;urothelial cancer: 3.2" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "OE19: 1194.0" "Not detected" "Not detected" "CAB009819, HPA054065, HPA056023" Enhanced Supported "Endoplasmic reticulum,Vesicles" NA NA "Cluster 85: Liver - Metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 34: Spermatids - Unknown function" Vesicles "Endoplasmic reticulum" "CAB009819: AB_2241481, HPA054065: AB_2682367, HPA056023: " "unprognostic (9.09e-2)" "unprognostic (6.07e-2)" "unprognostic (5.43e-2)" "unprognostic (6.03e-2)" "prognostic unfavorable (2.89e-6)" "unprognostic (2.79e-1)" "unprognostic (6.18e-2)" "unprognostic (2.09e-3)" "unprognostic (9.97e-2)" "unprognostic (2.16e-2)" "unprognostic (3.52e-1)" "unprognostic (7.50e-2)" "unprognostic (2.01e-2)" 0.1 0.0 0.0 0.1 0.0 0.0 0.8 0.0 0.0 1.8 0.0 1.8 5.8 0.1 2.6 16.1 0.0 3.5 0.0 0.0 0.0 71.3 143.3 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 1.1 1.3 0.0 2.6 3.6 0.0 11.1 2.6 0.0 0.0 0.0 17.4 0.4 0.0 1.2 0.5 0.0 5.8 88.8 5.5 0.0 4.2 1.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 53.8 1.6 0.0 80.2 0.1 0.8 294.5 0.1 4.0 0.0 0.0 0.0 0.0 0.3 1.3 0.0 0.0 0.3 0.0 31.2 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 6.2 0.0 0.0 0.0 1194.0 0.0 0.1 0.2 0.1 3.2 149.0 0.0 0.0 7.1 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 1.6 1.2 12.5 0.0 0.0 0.0 0.3 0.0 2.9 1.8 0.0 0.0 0.0 0.4 0.0 0.0 52.4 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 14.3 0.5 0.0 0.0 0.4 5.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 23.3 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.9 0.5 1.8 0.1 0.0 0.0 0.0 0.0 1.2 0.2 17.3 1.1 0.0 0.0 0.0 0.1 3.0 UGT1A7 UGT1G ENSG00000244122 "UDP glucuronosyltransferase family 1 member A7" Q9HAW7 2 233681938-233773299 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 12 "esophagus: 83.8" "Cell type enriched" "Detected in some" 4 "Squamous epithelial cells: 40.7" "Group enriched" "Detected in some" 10 "cervical cancer: 1.2;head and neck cancer: 2.3;lung cancer: 3.0" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 15 "SiHa: 112.2" NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 20: HeLa - Mitochondria" "Cluster 61: Squamous epithelial cells - Keratinization" "unprognostic (6.27e-2)" "unprognostic (1.02e-1)" "unprognostic (7.76e-2)" "unprognostic (1.03e-2)" "unprognostic (1.09e-1)" "unprognostic (7.92e-2)" "unprognostic (1.71e-7)" "unprognostic (2.14e-1)" "unprognostic (4.57e-2)" 0.1 1.3 0.2 0.0 0.2 0.0 0.4 0.5 0.8 1.2 0.4 0.3 0.2 0.0 0.0 83.8 0.0 0.0 0.0 0.3 0.2 0.7 4.3 0.0 0.0 0.2 0.5 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.1 5.6 0.0 0.0 3.6 0.1 0.0 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.0 5.2 0.4 7.1 1.0 0.0 1.8 0.1 0.0 0.8 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 112.2 7.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.5 0.8 0.3 0.2 0.2 0.5 0.2 0.1 0.3 1.0 0.0 0.0 0.0 0.0 0.0 0.4 2.3 1.3 4.6 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 2.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 2.8 0.7 0.3 0.2 0.0 0.0 0.0 0.2 0.0 0.0 40.7 1.7 0.0 0.0 0.0 0.5 8.5 UGT1A8 UGT1H ENSG00000242366 "UDP glucuronosyltransferase family 1 member A8" Q9HAW9 2 233617645-233773310 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 15.9;liver: 20.1;urinary bladder: 30.0" "Cell type enhanced" "Detected in some" "Basal respiratory cells: 4.5;Club cells: 1.0;Ionocytes: 2.0;Paneth cells: 2.5;Proximal enterocytes: 1.3;Squamous epithelial cells: 1.1" "Cancer enriched" "Detected in some" 5 "urothelial cancer: 2.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 64 "RT4: 121.4" NA NA "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 15: RT4 - Unknown function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "unprognostic (1.27e-2)" "unprognostic (1.35e-1)" "unprognostic (1.42e-3)" "unprognostic (1.23e-1)" "unprognostic (4.78e-1)" "unprognostic (9.71e-12)" "unprognostic (9.26e-2)" "unprognostic (1.96e-1)" 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.9 2.8 0.0 0.0 1.9 0.0 6.5 0.0 0.0 0.0 1.8 20.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 8.8 0.0 0.5 0.0 0.0 0.1 4.3 1.0 0.0 0.0 0.1 0.0 0.0 1.0 0.0 0.0 0.4 30.0 0.8 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 121.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 4.5 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 1.3 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.6 0.0 0.0 0.0 0.4 0.2 UGT1A9 "HLUGP4, LUGP4, UGT1AI" ENSG00000241119 "UDP glucuronosyltransferase family 1 member A9" O60656 2 233671898-233773300 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 370 "kidney: 458.6;liver: 195.6" "Group enriched" "Detected in some" 11 "Hepatocytes: 7.5;Proximal tubular cells: 6.6" "Group enriched" "Detected in some" 157 "liver cancer: 16.1;renal cancer: 16.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 13 "A549: 1.4;RT4: 1.2" NA NA "Cluster 81: Kidney & Liver - Metabolism" "Cluster 15: RT4 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "unprognostic (2.46e-2)" "unprognostic (3.56e-1)" "prognostic unfavorable (5.04e-5)" "unprognostic (4.26e-2)" "unprognostic (1.60e-1)" 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 458.6 195.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 6.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT2A1 ENSG00000173610 "UDP glucuronosyltransferase family 2 member A1 complex locus" P0DTE4 4 69588417-69653249 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Olfaction, Sensory transduction" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "choroid plexus: 3.6;kidney: 2.3;liver: 3.6;pituitary gland: 5.6" "Cell type enriched" "Detected in some" 18 "Proximal tubular cells: 107.9" "Cancer enhanced" "Detected in some" "liver cancer: 0.7;lung cancer: 0.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA017261, HPA045108" Uncertain NA NA "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA017261: AB_10963582, HPA045108: AB_2679218" "unprognostic (3.93e-3)" "unprognostic (5.62e-1)" "unprognostic (1.28e-4)" "unprognostic (1.74e-1)" "unprognostic (2.76e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.3 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.5 0.0 3.7 0.0 0.0 0.0 0.0 5.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 107.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 UGT2A3 FLJ21934 ENSG00000135220 "UDP glucuronosyltransferase family 2 member A3" Q6UWM9 4 68928463-68951804 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 7 "intestine: 31.4;kidney: 21.0;liver: 13.3;pancreas: 16.3" "Cell type enhanced" "Detected in some" "Cholangiocytes: 91.5;Distal enterocytes: 89.8;Hepatocytes: 53.5;Paneth cells: 54.7;Proximal enterocytes: 248.9;Proximal tubular cells: 130.8;Undifferentiated cells: 101.1" "Cancer enriched" "Detected in many" 5 "renal cancer: 46.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 59 "Hep G2: 5.8" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA045108 Supported NA NA "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 45: Enterocytes - Digestion" "HPA045108: AB_2679218" "prognostic favorable (3.31e-4)" "unprognostic (3.97e-3)" "unprognostic (8.87e-3)" "prognostic favorable (6.07e-7)" "unprognostic (2.10e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 22.7 9.4 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 21.0 13.3 0.0 0.0 0.0 0.0 0.0 16.3 0.0 0.0 0.0 0.0 0.0 9.3 0.0 0.0 0.0 0.0 0.0 31.4 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 91.5 0.0 3.7 0.0 0.0 0.0 89.8 11.7 26.3 0.0 0.0 0.0 0.0 12.2 2.7 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.4 53.5 0.0 0.0 0.0 34.0 0.0 1.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.1 54.7 0.0 0.0 0.0 248.9 130.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.1 0.0 101.1 0.0 UGT2B10 ENSG00000109181 "UDP glucuronosyltransferase family 2 member B10" P36537 4 68815994-68832023 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 149 "liver: 233.7" "Cell type enriched" "Detected in some" 11 "Hepatocytes: 245.3" "Cancer enriched" "Detected in single" 296 "liver cancer: 93.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 116 "Hep G2: 12.0" HPA045108 Uncertain NA NA "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" "HPA045108: AB_2679218" "unprognostic (3.50e-3)" "unprognostic (1.92e-3)" "unprognostic (4.17e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 233.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.6 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 21.0 0.1 0.0 0.3 0.0 10.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 245.3 0.0 0.0 0.0 0.3 0.0 7.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.4 0.0 0.2 0.0 UGT2B11 ENSG00000213759 "UDP glucuronosyltransferase family 2 member B11" O75310 4 69199951-69214748 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 21 "breast: 239.4" "Group enriched" "Detected in some" 4 "Breast glandular cells: 13.7;Cholangiocytes: 7.2" "Group enriched" "Detected in some" 17 "breast cancer: 17.4;liver cancer: 13.1" "Not detected" "Not detected" "Group enriched" "Detected in some" 42 "basophil: 4.7;eosinophil: 3.5" "Lineage enriched" "Detected in single" 47 "granulocytes: 4.7" "Not detected" "Not detected" HPA045108 Uncertain NA NA "Cluster 46: Basophils - DNA binding" "Cluster 5: Breast - Unknown function" "Cluster 35: Glandular cells - Unknown function" "HPA045108: AB_2679218" "unprognostic (1.12e-1)" "unprognostic (1.18e-3)" "unprognostic (1.49e-1)" "unprognostic (6.53e-2)" "unprognostic (2.26e-2)" "unprognostic (1.65e-1)" "unprognostic (7.84e-3)" "unprognostic (5.47e-1)" "unprognostic (1.32e-1)" "unprognostic (1.51e-3)" 0.1 0.0 0.0 0.1 0.0 0.1 239.4 0.0 0.0 0.1 0.0 0.1 0.7 0.0 0.9 0.0 0.5 11.4 0.0 0.0 0.0 3.6 9.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.1 0.0 0.4 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 4.7 0.0 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.7 0.5 0.0 7.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.3 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.1 UGT2B15 UGT2B8 ENSG00000196620 "UDP glucuronosyltransferase family 2 member B15" P54855 4 68646597-68670652 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid metabolism, Steroid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 9 "gallbladder: 77.7;liver: 291.2" "Group enriched" "Detected in some" 6 "Cholangiocytes: 168.7;Hepatocytes: 142.8" "Cancer enriched" "Detected in many" 10 "liver cancer: 120.2" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045108 Uncertain NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 2: Hepatocytes - Metabolism" "HPA045108: AB_2679218" "unprognostic (1.40e-1)" "unprognostic (2.25e-1)" "unprognostic (2.22e-2)" "unprognostic (3.86e-1)" "unprognostic (1.94e-1)" "prognostic favorable (9.82e-4)" "unprognostic (6.73e-2)" "unprognostic (3.49e-2)" "unprognostic (7.84e-2)" "unprognostic (5.81e-3)" "unprognostic (2.39e-2)" "unprognostic (5.38e-2)" "prognostic favorable (4.50e-4)" 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 21.6 5.1 0.0 0.0 0.0 0.1 77.7 0.0 0.0 0.0 0.0 291.2 0.0 0.0 0.0 0.0 0.0 12.9 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.1 0.0 0.0 0.0 13.0 0.0 0.0 0.1 17.0 0.5 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.2 0.0 0.0 4.4 0.9 0.1 168.7 0.1 0.0 0.0 0.0 0.0 0.3 0.0 24.2 3.0 0.2 0.0 0.2 0.0 2.7 0.1 3.6 0.1 0.1 0.0 0.0 0.0 0.0 2.9 142.8 0.0 0.0 0.1 3.3 0.0 3.2 0.0 0.6 0.0 0.4 0.0 0.0 0.6 0.0 0.0 0.0 0.0 14.6 1.1 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.9 0.1 0.6 1.0 0.0 0.0 0.0 0.4 0.0 0.5 0.9 UGT2B17 ENSG00000197888 "UDP glucuronosyltransferase family 2 member B17" O75795 4 68537184-68568527 "Enzymes, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Lipid metabolism, Steroid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 8 "intestine: 460.0;liver: 136.2" "Group enriched" "Detected in some" 6 "Distal enterocytes: 130.1;Paneth cells: 35.1;Undifferentiated cells: 100.6" "Group enriched" "Detected in many" 7 "colorectal cancer: 16.3;liver cancer: 10.1" "Not detected" "Not detected" "Group enriched" "Detected in some" 40 "memory B-cell: 2.8;naive B-cell: 8.8" "Lineage enriched" "Detected in single" 61 "B-cells: 8.8" "Cell line enhanced" "Detected in some" "BEWO: 1.0;NB-4: 1.1;RPMI-8226: 1.7" HPA045108 Supported NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 9: Intestine - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA045108: AB_2679218" "unprognostic (1.66e-1)" "unprognostic (2.97e-2)" "unprognostic (2.96e-2)" "unprognostic (2.41e-1)" "unprognostic (1.88e-1)" "unprognostic (1.19e-2)" "unprognostic (2.36e-1)" "unprognostic (8.44e-3)" "unprognostic (9.67e-2)" "unprognostic (4.80e-3)" "unprognostic (8.52e-2)" "unprognostic (2.45e-1)" "unprognostic (6.44e-2)" "unprognostic (1.75e-1)" "unprognostic (1.76e-1)" 0.3 0.0 0.0 38.8 0.0 0.0 0.7 0.0 0.0 1.5 0.0 365.7 364.3 1.4 1.5 0.1 0.2 0.6 0.0 0.0 0.0 0.2 136.2 0.2 1.5 0.3 0.0 0.0 0.5 0.0 0.0 0.0 0.2 0.1 125.8 0.0 0.2 0.7 0.0 0.0 460.0 9.1 0.1 0.6 0.8 0.0 0.1 0.4 0.0 0.0 2.2 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.8 0.0 0.0 0.0 8.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.1 0.1 0.1 0.0 0.0 1.3 0.0 1.1 0.0 0.0 0.4 0.0 0.0 0.2 0.1 0.0 1.5 0.6 0.0 0.0 0.0 0.0 130.1 0.0 0.0 0.0 11.1 0.1 0.0 1.8 0.0 0.2 0.0 0.1 0.0 0.0 1.0 0.0 0.0 0.4 2.8 0.0 0.0 0.1 13.8 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.5 0.3 0.1 35.1 0.0 1.0 0.0 0.0 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.5 0.0 100.6 0.2 UGT2B28 ENSG00000135226 "UDP glucuronosyltransferase family 2 member B28" Q9BY64 4 69280475-69295050 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 14 "breast: 198.5" "Cell type enriched" "Detected in single" 16 "Cholangiocytes: 10.0" "Cancer enriched" "Detected in single" 8 "breast cancer: 1.9" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "eosinophil: 1.3" "Lineage enriched" "Detected in single" 13 "granulocytes: 1.3" "Group enriched" "Detected in some" 10 "Daudi: 2.9;NB-4: 2.7" HPA045108 Uncertain "Intracellular and membrane" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 5: Breast - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA045108: AB_2679218" "unprognostic (1.81e-1)" "unprognostic (1.40e-1)" "unprognostic (7.20e-3)" "unprognostic (1.51e-2)" "unprognostic (4.37e-5)" "unprognostic (9.79e-4)" 0.0 0.0 0.0 0.0 0.0 0.0 198.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 10.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT2B4 UGT2B11 ENSG00000156096 "UDP glucuronosyltransferase family 2 member B4" P06133 4 69480165-69526014 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 107 "liver: 1273.7" "Cell type enriched" "Detected in some" 22 "Hepatocytes: 883.5" "Cancer enriched" "Detected in some" 96 "liver cancer: 351.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 9 "RH-30: 4.6" "CAB033260, HPA045108" Enhanced "Intracellular and membrane" NA NA "Cluster 62: Liver - Hemostasis" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 2: Hepatocytes - Metabolism" "CAB033260: AB_2241496, HPA045108: AB_2679218" "unprognostic (7.46e-2)" "unprognostic (1.50e-1)" "unprognostic (9.37e-2)" "unprognostic (1.51e-1)" "unprognostic (2.47e-2)" "unprognostic (1.47e-1)" "unprognostic (9.43e-3)" "unprognostic (3.52e-1)" 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 11.9 0.0 0.0 1.3 1273.7 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.6 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 39.4 12.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.1 0.0 10.7 0.1 0.0 0.0 1.2 0.0 0.0 0.0 0.0 11.7 883.5 0.1 0.0 0.1 0.0 0.0 15.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.9 0.1 0.0 0.0 UGT2B7 UGT2B9 ENSG00000171234 "UDP glucuronosyltransferase family 2 member B7" P16662 4 69051363-69112987 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid metabolism, Steroid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 21 "kidney: 1299.8;liver: 1612.1" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 150.6;Glandular and luminal cells: 234.7;Hepatocytes: 550.8;Proximal tubular cells: 1249.5" "Group enriched" "Detected in many" 7 "liver cancer: 116.4;renal cancer: 101.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "RPTEC TERT1: 310.8" HPA045108 Uncertain NA NA "Cluster 81: Kidney & Liver - Metabolism" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA045108: AB_2679218" "unprognostic (1.04e-1)" "unprognostic (1.65e-1)" "prognostic favorable (7.65e-5)" "unprognostic (1.11e-2)" "unprognostic (2.10e-1)" "unprognostic (2.30e-2)" "unprognostic (5.41e-3)" "unprognostic (1.68e-1)" "unprognostic (1.74e-2)" "unprognostic (1.17e-3)" "unprognostic (1.98e-1)" "prognostic favorable (3.79e-4)" "unprognostic (1.08e-2)" "unprognostic (2.55e-1)" "unprognostic (6.23e-3)" "prognostic favorable (5.38e-4)" 0.2 0.0 0.0 0.3 0.0 0.0 2.3 0.0 0.0 32.0 0.0 3.8 68.7 8.9 24.2 0.2 49.9 10.4 0.0 0.0 0.0 1299.8 1612.1 0.4 0.0 0.0 0.0 0.1 9.9 0.0 0.0 0.1 0.0 0.3 6.9 0.0 3.6 27.5 0.0 0.3 66.6 0.3 0.0 0.0 0.9 0.1 0.0 0.9 0.0 0.0 0.2 1.6 0.0 0.0 0.0 0.3 0.2 0.3 0.0 0.0 0.2 0.0 2.5 0.0 0.0 0.3 0.0 0.0 77.6 0.0 0.0 0.0 0.0 0.1 0.0 1.0 0.0 0.1 0.0 41.9 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 2.3 0.0 0.1 0.6 0.1 310.8 2.7 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 43.2 0.0 0.0 0.0 0.2 0.3 0.2 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.7 0.1 0.6 1.6 0.0 0.0 1.2 0.6 0.1 38.6 2.1 125.0 0.0 0.0 0.0 5.7 97.8 6.6 0.3 150.6 14.0 1.0 3.5 2.7 0.4 10.6 0.0 0.1 0.0 234.7 0.0 0.0 8.9 550.8 0.1 0.0 0.3 37.3 0.0 13.8 0.0 0.0 1.8 7.6 3.6 0.0 0.0 0.0 0.0 1.5 0.4 13.0 10.7 0.0 0.0 0.6 70.6 1249.5 0.5 0.0 0.0 0.0 0.6 0.0 0.2 0.0 0.1 0.0 6.3 0.1 5.9 2.3 UGT3A1 FLJ34658 ENSG00000145626 "UDP glycosyltransferase family 3 member A1" Q6NUS8 5 35951006-36001028 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "kidney: 51.1;liver: 58.0" "Cell type enhanced" "Detected in some" "Collecting duct cells: 49.7;Early spermatids: 125.9;Hepatocytes: 72.1;Late spermatids: 24.5;Proximal tubular cells: 87.0" "Group enriched" "Detected in some" 15 "liver cancer: 6.7;renal cancer: 4.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 42 "RH-30: 28.2" "HPA047697, HPA056290" Uncertain Approved Vesicles,Cytosol NA NA "Cluster 81: Kidney & Liver - Metabolism" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Vesicles, Cytosol" "HPA047697: AB_2680122, HPA056290: AB_2683088" "unprognostic (2.41e-3)" "unprognostic (4.47e-1)" "unprognostic (4.04e-1)" "unprognostic (4.62e-1)" "unprognostic (1.42e-2)" "unprognostic (6.05e-2)" "unprognostic (9.14e-2)" "unprognostic (1.76e-1)" 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.4 0.0 0.0 0.0 9.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 51.1 58.0 0.0 0.0 0.1 0.0 0.2 0.0 0.4 0.2 0.0 0.1 0.3 0.0 0.7 0.1 0.2 3.0 0.0 6.7 0.0 0.0 0.0 0.0 5.6 0.0 0.0 0.1 2.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.1 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 28.2 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.4 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 4.1 0.0 0.0 0.4 0.0 0.0 49.7 0.0 0.0 0.0 0.0 3.9 0.0 125.9 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.8 72.1 0.1 0.0 0.3 0.7 0.0 2.6 0.0 24.5 0.9 0.6 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 2.5 0.4 0.0 0.0 3.8 87.0 0.0 0.2 6.6 0.0 0.0 4.4 0.8 0.0 0.0 0.0 0.5 0.0 1.8 0.1 UGT3A2 ENSG00000168671 "UDP glycosyltransferase family 3 member A2" Q3SY77 5 36035021-36071358 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 6.5;lymphoid tissue: 14.7;skin 1: 10.3" "Group enriched" "Detected in some" 4 "Collecting duct cells: 3.7;Early spermatids: 4.4;Late spermatids: 8.2;Proximal tubular cells: 3.8" "Cancer enriched" "Detected in some" 5 "testis cancer: 4.4" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HDLM-2: 6.8;JURKAT: 6.3;MOLT-4: 12.4;REH: 29.9;SuSa: 11.8;T-47d: 7.2;THP-1: 18.0" "Low region specificity" "Detected in many" HPA059475 Uncertain Approved "Nucleoplasm,Golgi apparatus,Cytosol" Yes NA "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 14: REH - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "Golgi apparatus, Cytosol" "HPA059475: AB_2684031" "unprognostic (1.83e-4)" "unprognostic (9.94e-2)" "unprognostic (8.87e-2)" "unprognostic (4.82e-4)" "unprognostic (3.18e-1)" "unprognostic (3.52e-2)" "unprognostic (1.56e-1)" "unprognostic (6.08e-2)" "unprognostic (2.04e-1)" "unprognostic (8.13e-2)" "unprognostic (7.49e-2)" "unprognostic (4.17e-2)" "unprognostic (1.36e-3)" "unprognostic (6.65e-2)" "unprognostic (7.52e-2)" "unprognostic (7.38e-2)" "unprognostic (4.52e-3)" 0.0 0.8 0.0 0.0 0.0 6.5 1.1 0.3 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.3 2.6 0.6 0.0 0.0 1.0 1.1 0.0 0.0 0.1 0.9 0.2 1.2 0.4 0.0 0.1 0.1 0.0 0.1 10.3 0.0 0.0 0.1 1.2 0.1 2.9 0.6 14.7 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.6 1.8 0.0 0.1 0.0 0.0 0.3 0.4 0.0 1.3 0.0 0.5 6.8 4.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 6.3 0.0 0.0 0.0 0.0 12.4 0.0 5.3 0.0 0.0 29.9 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.8 7.2 18.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.3 1.0 1.1 1.2 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 3.7 0.0 0.2 0.0 0.0 0.0 0.0 4.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.7 0.0 0.0 0.0 0.1 0.0 0.7 0.1 0.0 0.1 0.0 0.0 0.0 1.1 8.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.2 0.0 0.0 0.0 0.3 0.1 0.0 3.8 0.0 0.0 0.0 0.0 0.0 0.3 0.9 0.0 0.0 0.3 0.0 0.1 0.0 0.0 UHMK1 "KIS, Kist" ENSG00000152332 "U2AF homology motif kinase 1" Q8TAS1 1 162497251-162529631 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, RNA-binding, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA077624 Supported "Nucleoplasm,Nuclear speckles,Vesicles" NA No "Cluster 51: Monocytes - Innate immune response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 59: Non-specific - Transcription" "Nucleoplasm, Nuclear speckles" Vesicles "HPA077624: " "unprognostic (6.69e-2)" "unprognostic (1.28e-1)" "unprognostic (1.05e-1)" "unprognostic (1.46e-1)" "unprognostic (1.28e-1)" "unprognostic (1.33e-1)" "unprognostic (2.08e-2)" "unprognostic (8.16e-2)" "unprognostic (9.63e-2)" "unprognostic (1.82e-1)" "unprognostic (7.81e-3)" "unprognostic (9.10e-2)" "unprognostic (3.11e-1)" "unprognostic (3.44e-2)" "unprognostic (9.08e-2)" "unprognostic (8.77e-2)" "unprognostic (4.66e-2)" 26.8 23.3 21.2 23.3 24.6 40.3 19.3 18.1 21.2 15.1 16.6 19.2 19.1 11.7 14.1 13.3 14.4 13.7 11.6 26.0 28.3 31.2 38.1 17.5 30.8 24.9 28.5 11.9 11.0 27.8 7.8 17.1 28.3 16.2 19.6 10.5 13.5 18.5 25.8 11.9 23.4 10.8 19.8 25.4 20.0 12.2 26.1 24.6 19.4 25.9 28.9 18.1 10.5 19.4 61.9 28.4 14.6 35.8 40.7 31.9 32.7 79.7 43.2 63.9 45.7 18.6 37.8 50.2 67.8 60.0 31.2 34.9 28.2 44.1 102.4 69.1 20.4 49.8 34.3 16.9 31.3 73.4 55.5 33.0 45.8 63.2 59.9 44.6 37.4 34.2 44.1 67.7 111.4 26.0 39.3 19.4 19.4 46.1 37.8 24.9 64.9 41.9 42.6 62.8 26.4 24.3 70.5 64.6 52.2 19.9 56.0 81.0 58.5 72.7 41.0 50.8 112.6 69.2 103.5 58.0 60.5 35.3 67.3 3.6 2.0 2.4 4.8 5.3 4.9 3.2 3.5 4.0 2.3 3.6 3.5 4.0 1.3 3.7 6.1 2.6 3.1 2.6 21.2 24.6 18.1 21.2 26.0 28.3 24.9 28.5 28.3 19.8 26.1 19.4 37.6 19.2 41.2 20.9 75.6 29.4 33.7 38.5 34.7 24.4 39.4 20.2 35.1 40.0 53.8 53.3 12.5 26.2 81.0 53.9 56.7 27.6 55.6 35.1 35.7 33.4 33.5 51.6 37.0 23.2 38.1 25.5 43.3 44.4 45.7 23.3 31.1 85.1 30.0 23.5 27.4 34.1 48.8 73.5 47.5 58.4 21.5 60.0 28.4 33.7 58.0 14.6 74.2 20.6 29.5 40.4 33.0 19.5 47.2 59.9 60.8 62.2 50.9 23.0 0.0 29.2 27.8 25.1 29.6 45.2 24.6 22.4 69.4 31.4 39.3 58.3 UHRF1 "FLJ21925, ICBP90, Np95, RNF106, TDRD22" ENSG00000276043 "Ubiquitin like with PHD and ring finger domains 1" Q96T88 19 4903080-4962154 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, DNA damage, DNA repair, Transcription, Transcription regulation, Ubl conjugation pathway" "Chromatin regulator, DNA-binding, Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "bone marrow: 27.0;lymphoid tissue: 67.2" "Cell type enhanced" "Detected in many" "Erythroid cells: 49.7;Plasma cells: 21.0;Squamous epithelial cells: 15.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "plasmacytoid DC: 4.8" "Group enriched" "Detected in many" 4 "dendritic cells: 4.8;T-cells: 2.3" "Cell line enhanced" "Detected in all" "MOLT-4: 450.9;REH: 1004.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA049408, HPA055446" Enhanced Supported Nucleoplasm No Yes "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 14: REH - Unknown function" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "HPA049408: AB_2756317, HPA055446: AB_2732597" "unprognostic (3.83e-2)" "unprognostic (6.83e-3)" "unprognostic (5.13e-2)" "unprognostic (1.69e-1)" "unprognostic (1.40e-1)" "unprognostic (7.21e-2)" "prognostic unfavorable (1.63e-4)" "unprognostic (4.30e-2)" "prognostic unfavorable (6.81e-4)" "unprognostic (2.82e-1)" "prognostic unfavorable (4.52e-5)" "unprognostic (2.33e-3)" "unprognostic (0.00e+0)" "unprognostic (3.75e-3)" "unprognostic (2.45e-1)" "unprognostic (2.01e-1)" "unprognostic (2.02e-1)" 1.0 0.9 2.1 9.6 2.7 27.0 1.7 2.1 2.3 1.6 1.8 2.9 3.7 1.0 0.1 6.5 0.4 0.8 0.5 2.0 2.2 0.6 0.9 1.3 15.8 2.8 2.8 0.3 0.6 0.2 0.2 2.1 2.7 0.6 2.6 0.4 1.5 0.2 1.2 3.4 3.9 1.9 1.9 3.7 3.3 5.2 3.5 67.2 0.3 0.3 10.3 1.6 2.5 4.6 111.3 78.7 116.6 83.4 3.3 13.3 18.5 88.3 42.0 89.9 86.8 94.6 54.9 62.7 21.1 39.4 32.7 54.1 81.2 47.7 63.0 102.7 92.2 54.3 74.3 102.4 1.3 135.1 78.9 6.5 3.5 48.9 12.6 14.1 27.2 97.2 79.3 70.5 54.5 86.7 450.9 82.5 52.5 40.0 84.3 1004.5 259.7 45.4 24.9 80.1 86.0 68.5 69.2 37.7 12.1 18.8 68.2 127.6 34.2 94.6 76.7 124.3 108.3 29.8 33.1 183.5 54.8 129.7 123.3 0.3 0.2 0.1 0.6 0.0 0.0 0.2 0.8 1.0 1.3 0.1 0.2 0.8 0.8 0.5 0.2 4.8 2.3 0.6 2.1 2.7 2.1 2.3 2.0 2.2 2.8 2.8 2.7 1.9 3.5 4.6 0.2 0.0 0.0 1.6 2.1 0.0 0.8 0.0 3.4 2.5 4.4 2.8 4.3 1.5 0.6 0.0 0.0 6.6 6.9 2.6 0.0 2.2 2.9 1.3 1.8 2.2 0.0 49.7 0.4 0.4 7.8 4.7 8.6 2.4 0.0 10.4 0.4 0.7 8.9 3.3 0.4 2.3 0.0 1.9 0.0 1.8 0.6 3.8 0.0 0.0 2.0 0.6 1.0 3.0 1.3 4.2 1.9 0.4 21.0 0.6 1.4 0.2 0.7 0.7 0.0 1.2 6.1 6.1 11.9 15.8 0.0 1.4 3.7 1.5 8.3 1.3 UHRF2 "MGC33463, NIRF, RNF107, TDRD23, URF2" ENSG00000147854 "Ubiquitin like with PHD and ring finger domains 2" Q96PU4 9 6413151-6507054 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Ubl conjugation pathway" "DNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 78.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026633, HPA026697" Enhanced Nucleoplasm NA NA "Cluster 46: Basophils - DNA binding" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 43: Cardiomyocytes - Nuclear processes" Nucleoplasm "HPA026633: AB_2732431, HPA026697: AB_2732432" "unprognostic (1.08e-1)" "unprognostic (1.13e-1)" "unprognostic (1.52e-1)" "unprognostic (1.68e-1)" "unprognostic (1.12e-1)" "unprognostic (8.40e-2)" "unprognostic (4.35e-3)" "unprognostic (4.12e-2)" "unprognostic (1.53e-1)" "unprognostic (4.17e-2)" "unprognostic (1.73e-1)" "unprognostic (5.69e-3)" "unprognostic (2.14e-2)" "unprognostic (6.21e-2)" "unprognostic (8.77e-2)" "unprognostic (7.42e-2)" "unprognostic (1.50e-1)" 10.0 8.1 8.2 9.9 10.3 44.6 9.7 14.9 10.4 12.9 10.4 11.6 6.2 12.9 10.0 8.3 9.9 7.9 7.2 8.7 9.2 8.1 7.9 7.8 17.3 9.4 8.6 12.4 10.7 9.7 5.4 12.1 9.4 15.3 9.2 9.2 8.5 12.6 11.0 7.7 8.5 14.0 8.8 10.4 8.3 8.4 10.0 21.2 8.1 11.9 16.6 11.4 10.1 14.3 18.1 18.8 26.7 11.9 21.4 30.7 20.5 43.9 23.4 23.7 41.2 12.4 12.0 26.9 9.2 19.2 21.8 11.9 24.6 22.5 36.0 53.6 14.9 46.3 36.2 19.7 17.8 19.3 16.1 13.5 14.1 18.4 44.5 44.4 93.2 25.4 5.1 24.0 56.0 5.9 37.0 79.2 10.8 24.8 14.8 43.1 12.4 8.7 17.2 11.3 24.8 9.4 16.6 11.0 25.6 32.1 14.0 41.9 78.6 25.2 10.0 11.0 34.4 7.2 23.2 30.4 12.4 18.2 10.2 4.0 0.5 2.7 1.2 0.5 0.8 1.8 1.8 1.0 0.3 2.9 1.0 1.2 0.5 0.6 0.9 1.2 1.9 0.6 8.2 10.3 14.9 10.4 8.7 9.2 9.4 8.6 9.4 8.8 10.0 14.3 27.5 6.4 14.4 24.2 33.9 21.5 10.2 6.2 12.0 22.0 13.8 13.1 59.0 4.3 8.4 12.9 31.3 13.2 31.3 9.1 1.9 5.2 23.6 12.8 22.9 24.1 7.1 34.9 44.2 4.0 9.9 16.0 20.9 24.5 17.7 27.8 12.8 14.6 10.7 28.6 53.3 14.8 4.1 12.6 9.3 8.1 19.3 15.6 21.4 51.5 12.5 6.4 16.5 46.8 78.6 6.2 14.4 14.7 30.1 16.0 10.2 7.3 6.3 34.8 13.1 14.4 18.8 46.2 23.4 16.1 19.0 5.9 29.0 13.7 12.6 9.8 ULK1 "ATG1, ATG1A" ENSG00000177169 "Unc-51 like autophagy activating kinase 1" O75385 12 131894622-131923150 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Autophagy "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Rod photoreceptor cells: 84.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 4.0;plasmacytoid DC: 3.8" "Group enriched" "Detected in many" 4 "dendritic cells: 3.8;granulocytes: 4.0" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063990 Approved Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 59: Non-specific - Translation" "Cluster 24: NB-4 - Immune response" "Cluster 46: Photoreceptor cells - Phototransduction" Cytosol "HPA063990: AB_2685167" "unprognostic (1.53e-1)" "unprognostic (5.19e-2)" "unprognostic (2.52e-3)" "unprognostic (2.21e-3)" "unprognostic (8.01e-3)" "unprognostic (5.48e-2)" "unprognostic (2.74e-2)" "unprognostic (5.04e-3)" "unprognostic (3.94e-3)" "unprognostic (2.03e-2)" "unprognostic (9.09e-3)" "unprognostic (8.19e-2)" "unprognostic (6.25e-2)" "unprognostic (2.38e-1)" "unprognostic (2.75e-1)" "unprognostic (1.82e-2)" "unprognostic (3.16e-1)" 19.9 30.1 21.2 7.2 46.0 31.4 20.9 8.3 28.4 31.5 6.2 31.2 9.0 27.2 6.5 21.5 27.2 9.3 35.0 24.4 4.7 21.7 36.4 20.9 6.7 10.9 8.7 39.9 55.6 12.1 47.2 7.1 9.6 27.8 2.3 14.4 21.4 9.4 81.6 43.1 19.5 4.9 1.5 29.3 27.8 17.8 9.9 7.9 24.5 13.8 2.9 23.1 26.8 12.4 9.1 28.8 13.1 16.4 5.8 4.7 17.8 14.1 10.1 5.9 4.8 6.3 9.2 2.4 14.5 10.0 12.0 8.9 3.0 5.6 1.7 9.8 17.2 6.1 25.2 8.6 10.8 4.4 12.9 8.6 15.1 6.6 2.7 16.4 7.3 18.2 8.1 7.0 4.0 20.6 27.5 25.6 14.4 4.3 27.2 20.5 4.7 12.2 3.5 11.1 33.1 18.2 15.1 15.3 7.9 13.1 23.4 29.5 14.2 14.1 8.3 24.8 6.6 30.9 12.0 3.3 23.8 7.6 16.6 0.2 0.9 1.4 0.4 0.4 0.1 0.1 0.3 0.4 0.2 0.3 0.2 0.3 4.0 0.1 0.4 3.8 0.3 0.4 21.2 46.0 8.3 28.4 24.4 4.7 10.9 8.7 9.6 1.5 9.9 12.4 15.6 16.0 17.4 17.9 7.8 14.4 6.1 11.6 9.6 25.0 19.6 14.4 22.0 15.7 15.6 7.3 39.6 5.7 23.7 10.5 1.9 8.5 0.8 19.1 35.7 14.9 19.2 12.0 27.0 12.7 4.2 13.1 13.3 28.0 3.8 24.4 8.6 33.8 5.4 53.8 21.9 14.6 18.3 12.0 6.7 3.0 12.5 13.1 5.4 11.2 12.3 14.7 5.2 20.1 13.9 24.5 7.7 15.8 11.9 15.0 9.9 3.2 13.9 84.3 13.1 19.5 16.9 6.8 7.5 9.7 19.5 17.2 9.1 8.8 7.7 9.5 ULK2 "ATG1B, KIAA0623, Unc51.2" ENSG00000083290 "Unc-51 like autophagy activating kinase 2" Q8IYT8 17 19770829-19867936 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Autophagy, Neurogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 62.0;Inhibitory neurons: 76.9;Late spermatids: 70.1;Oligodendrocytes: 94.6;Spermatocytes: 58.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "intermediate monocyte: 4.0;non-classical monocyte: 3.4" "Lineage enriched" "Detected in single" 5 "monocytes: 4.0" "Cell line enhanced" "Detected in many" "SuSa: 43.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB037021 Approved NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 78: Testis - Spermatogenesis" "Cluster 12: NES - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB037021: AB_1841237" "unprognostic (1.47e-1)" "unprognostic (1.88e-1)" "unprognostic (2.56e-1)" "unprognostic (1.03e-1)" "unprognostic (1.23e-1)" "unprognostic (1.31e-1)" "unprognostic (6.53e-2)" "unprognostic (1.07e-1)" "unprognostic (5.83e-2)" "unprognostic (1.39e-2)" "unprognostic (5.11e-3)" "unprognostic (1.39e-1)" "unprognostic (1.16e-1)" "unprognostic (3.44e-1)" "unprognostic (2.69e-1)" "unprognostic (3.23e-1)" "unprognostic (1.38e-2)" 10.5 6.9 14.3 4.6 19.8 3.0 7.8 16.9 14.9 10.0 9.7 10.8 3.0 9.3 6.4 6.3 10.8 7.4 8.3 14.9 12.1 6.5 3.4 8.4 4.8 22.1 18.8 11.4 7.5 13.3 5.3 8.1 20.7 8.0 4.2 9.4 5.9 9.8 15.2 7.5 4.7 9.5 18.3 7.1 7.5 33.8 16.6 3.9 6.4 14.7 3.7 9.0 8.5 26.5 12.7 13.1 18.0 2.4 10.2 19.3 0.0 10.3 12.8 10.6 9.8 0.2 2.6 0.0 5.4 13.4 12.0 5.8 0.0 2.1 9.9 10.6 13.2 0.3 5.2 0.0 13.1 0.0 6.3 12.5 15.6 5.4 4.4 9.3 7.6 0.0 0.0 0.0 8.1 3.4 0.0 0.5 2.7 0.2 3.3 0.8 0.0 0.0 7.3 5.3 4.6 18.7 16.4 2.0 5.2 43.7 12.6 4.5 12.0 0.0 1.5 3.7 6.3 0.0 0.0 0.0 1.6 0.0 3.8 0.0 0.9 0.2 0.2 4.0 0.1 0.0 0.5 0.5 0.8 0.0 0.8 0.5 0.2 0.2 3.4 0.0 0.1 0.3 14.3 19.8 16.9 14.9 14.9 12.1 22.1 18.8 20.7 18.3 16.6 26.5 8.9 19.2 14.1 32.3 1.8 7.4 4.7 3.2 6.8 16.1 9.5 8.1 10.9 4.3 6.1 7.3 8.4 7.7 4.4 1.4 3.9 3.1 34.2 19.6 15.3 5.3 2.4 6.7 62.0 3.4 2.8 12.0 6.6 11.3 0.0 18.0 3.6 1.7 8.5 15.2 76.9 3.9 4.1 20.5 5.1 70.1 14.0 9.1 8.8 41.2 12.3 6.1 7.2 35.2 94.6 2.5 2.4 12.4 2.1 7.5 1.0 5.4 10.0 12.7 13.1 11.5 12.7 58.2 22.1 8.6 9.7 2.9 4.7 6.6 2.9 3.8 ULK3 "DKFZP434C131, FLJ90566" ENSG00000140474 "Unc-51 like kinase 3" Q6PHR2 15 74836118-74843346 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Autophagy "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Bipolar cells: 89.7;Horizontal cells: 89.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040474 Approved NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 27: Brain & Skin - Unknown function" "Cluster 44: HDLM-2 - Immune response" "Cluster 62: Horizontal cells - Visual perception" "HPA040474: AB_2677003" "unprognostic (3.67e-2)" "unprognostic (8.90e-3)" "unprognostic (2.65e-3)" "unprognostic (1.59e-2)" "unprognostic (1.70e-1)" "unprognostic (2.07e-3)" "unprognostic (1.19e-1)" "unprognostic (1.58e-2)" "unprognostic (1.47e-2)" "unprognostic (4.18e-2)" "prognostic favorable (7.47e-4)" "unprognostic (1.97e-2)" "unprognostic (2.70e-2)" "unprognostic (1.30e-2)" "unprognostic (1.63e-1)" "unprognostic (1.16e-1)" "unprognostic (4.97e-3)" 7.1 15.2 29.5 6.4 31.5 2.2 6.1 28.1 32.2 13.6 23.0 12.1 5.0 4.4 3.5 35.7 5.5 4.5 15.9 29.4 27.3 17.6 13.8 8.3 5.8 34.0 26.6 5.7 12.0 16.2 12.5 3.5 35.8 9.9 9.4 15.4 11.5 3.1 21.0 24.7 15.7 4.4 26.1 13.1 10.6 7.1 27.8 6.3 7.6 19.0 7.8 9.4 15.4 30.4 6.7 17.7 7.4 14.4 9.3 6.7 6.0 5.1 7.3 10.1 11.1 7.0 15.4 13.0 8.8 6.2 10.8 4.7 23.1 7.6 4.4 26.1 26.1 30.3 25.0 7.4 14.8 10.3 22.5 9.4 14.0 8.2 7.1 3.5 15.8 16.8 10.3 11.9 7.0 9.4 7.3 6.6 10.0 10.6 8.7 18.6 10.3 23.0 6.0 7.4 16.7 22.3 8.6 9.8 25.6 9.1 11.0 26.8 9.4 16.0 8.9 12.7 10.3 20.7 19.7 9.3 7.4 29.5 12.4 5.2 3.5 1.4 10.9 7.3 8.7 3.3 6.4 9.0 3.7 2.8 7.1 4.8 0.8 5.8 6.1 4.0 9.2 5.1 29.5 31.5 28.1 32.2 29.4 27.3 34.0 26.6 35.8 26.1 27.8 30.4 16.5 9.6 15.3 37.2 11.4 10.1 7.5 6.0 10.2 89.7 18.1 13.6 17.1 14.3 6.7 12.9 16.7 9.2 23.3 46.4 19.6 11.0 1.0 8.9 8.8 10.7 11.4 14.1 64.7 11.7 2.5 9.2 23.4 11.9 21.0 6.2 13.2 13.3 16.1 89.2 56.5 17.5 4.1 7.9 8.2 2.2 13.1 11.2 5.4 18.7 13.2 18.4 29.9 16.6 15.3 12.3 17.9 11.7 8.6 10.4 68.5 16.5 8.0 54.5 0.0 12.9 8.8 9.5 17.3 19.7 21.7 5.7 19.7 12.3 27.9 8.9 ULK4 "FAM7C1, FLJ20574, REC01035" ENSG00000168038 "Unc-51 like kinase 4" Q96C45 3 41246599-41962130 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 23.4" "Cell type enhanced" "Detected in many" "Early spermatids: 352.3;Excitatory neurons: 108.6;Inhibitory neurons: 99.2;Late spermatids: 405.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA017930 Uncertain Approved Nucleoplasm,Mitochondria,Cytosol NA NA "Cluster 35: T-regs - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 18: U-2197 - ECM organization" "Cluster 34: Spermatids - Unknown function" "Nucleoplasm, Mitochondria, Cytosol" "HPA017930: AB_1858615" "unprognostic (3.16e-2)" "unprognostic (2.98e-3)" "unprognostic (9.72e-3)" "unprognostic (3.46e-2)" "unprognostic (2.58e-1)" "unprognostic (8.68e-2)" "unprognostic (1.87e-1)" "unprognostic (3.50e-2)" "unprognostic (1.80e-1)" "unprognostic (1.41e-1)" "unprognostic (3.75e-3)" "unprognostic (3.43e-1)" "unprognostic (1.91e-2)" "unprognostic (5.46e-2)" "unprognostic (1.61e-1)" "unprognostic (2.53e-1)" "unprognostic (6.12e-2)" 2.7 3.1 1.6 2.9 2.1 8.5 2.5 0.4 1.7 8.5 16.9 1.6 1.2 6.6 4.5 1.5 9.0 1.9 8.6 2.3 2.5 3.9 2.1 3.5 3.0 6.9 7.6 2.1 2.0 8.0 2.9 2.7 3.9 2.2 1.7 6.0 1.7 2.4 0.4 2.1 2.0 3.5 5.6 2.0 2.4 23.4 2.5 3.0 4.9 0.4 2.7 1.9 3.7 2.1 8.3 2.9 2.8 3.8 1.1 1.7 4.8 2.7 2.7 3.2 3.0 1.0 2.3 9.5 1.6 6.3 3.5 4.1 3.7 2.1 2.9 1.5 1.0 2.1 5.7 3.3 4.1 6.5 1.8 1.6 2.3 16.1 3.2 4.4 2.2 6.4 2.1 7.5 2.3 6.4 8.1 4.9 3.4 2.1 3.4 1.7 9.1 4.5 7.2 7.6 1.6 10.3 3.1 1.3 2.8 1.8 3.1 2.0 6.6 2.0 2.4 14.2 2.5 4.5 9.0 3.9 11.5 6.3 2.5 3.7 3.7 4.0 5.0 4.3 4.1 3.7 5.3 4.5 3.3 4.7 4.0 5.7 6.6 1.8 2.3 3.3 7.7 3.0 1.6 2.1 0.4 1.7 2.3 2.5 6.9 7.6 3.9 5.6 2.5 2.1 6.4 9.6 6.9 84.9 11.2 2.0 3.0 4.0 5.2 5.6 5.7 4.6 14.8 4.3 5.1 3.7 54.2 3.1 9.9 2.0 0.0 3.4 352.3 45.3 27.4 6.0 1.8 2.1 108.6 2.4 4.1 8.7 10.2 7.5 1.3 49.6 1.8 6.6 7.3 11.8 99.2 1.2 2.0 3.1 4.0 405.2 6.5 6.9 0.0 80.6 5.9 10.4 3.1 49.8 62.0 3.0 0.7 4.1 5.1 0.9 1.1 5.9 47.3 26.7 6.6 4.4 10.5 38.9 9.6 3.3 3.7 4.2 10.8 3.6 1.9 1.2 USP1 ENSG00000162607 "Ubiquitin specific peptidase 1" O94782 1 62436297-62451804 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 302.7;Spermatogonia: 206.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028387, HPA028440" Approved Supported Nucleoplasm NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "HPA028387: AB_2672578, HPA028440: AB_10603000" "unprognostic (1.22e-1)" "unprognostic (5.36e-2)" "unprognostic (1.78e-3)" "unprognostic (4.05e-3)" "unprognostic (2.57e-1)" "unprognostic (1.72e-2)" "prognostic unfavorable (5.81e-5)" "unprognostic (6.72e-2)" "unprognostic (1.11e-2)" "unprognostic (5.32e-2)" "unprognostic (3.33e-3)" "unprognostic (3.99e-2)" "unprognostic (2.76e-2)" "unprognostic (9.61e-3)" "unprognostic (5.70e-2)" "unprognostic (1.96e-1)" "unprognostic (1.71e-1)" 13.8 10.6 12.4 21.0 14.7 53.2 23.9 20.2 15.4 16.2 11.8 19.0 17.1 20.7 16.8 17.9 16.7 11.9 12.2 11.5 13.4 14.1 13.5 16.0 32.3 12.8 13.0 26.0 16.0 18.2 10.0 14.4 13.7 16.7 20.7 34.5 14.7 15.9 11.9 19.3 17.2 17.0 14.2 19.4 16.9 51.5 12.9 48.1 20.2 16.0 31.7 13.9 11.9 17.3 85.6 25.5 96.8 53.2 21.3 25.5 57.0 79.7 52.1 93.3 101.2 41.4 39.3 151.3 57.0 43.1 83.6 48.0 80.3 53.0 128.5 79.5 63.5 124.5 82.1 42.7 23.2 132.5 60.9 13.7 33.8 84.1 62.8 25.1 44.9 100.1 92.7 125.3 66.2 38.0 136.9 50.9 88.2 48.5 52.4 131.9 166.3 93.9 34.9 60.1 103.4 58.6 89.3 70.1 86.8 64.2 41.3 79.7 32.1 72.7 80.7 109.3 112.9 52.2 78.1 171.1 49.5 104.0 67.0 22.6 9.9 26.0 12.7 10.5 16.9 15.6 15.3 13.5 12.3 11.2 14.4 12.2 17.4 17.9 14.9 12.4 15.3 10.3 12.4 14.7 20.2 15.4 11.5 13.4 12.8 13.0 13.7 14.2 12.9 17.3 35.8 48.1 31.8 6.2 58.7 62.2 34.7 32.9 75.7 49.6 41.5 46.2 34.9 24.3 34.9 16.5 22.9 43.7 52.4 22.7 19.6 34.1 173.9 37.2 32.3 39.7 8.4 85.2 10.3 34.1 59.2 43.9 15.8 33.2 27.8 41.4 30.0 18.4 31.0 35.3 11.2 33.3 30.5 27.2 38.8 81.1 50.1 34.7 26.6 7.5 56.0 49.5 62.8 10.6 17.2 27.5 12.7 41.0 63.7 56.8 22.7 17.3 41.9 86.6 52.6 59.7 42.0 302.7 206.7 73.8 64.4 33.0 59.7 21.2 39.5 35.8 USP10 "KIAA0190, UBPO" ENSG00000103194 "Ubiquitin specific peptidase 10" Q14694 16 84699986-84779922 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Autophagy, DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 5 "neutrophil: 742.4" "Lineage enriched" "Detected in all" 5 "granulocytes: 742.4" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006731, HPA006749" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Cytosol Nucleoplasm "HPA006731: AB_1080495, HPA006749: AB_1080492" "unprognostic (4.14e-2)" "unprognostic (2.28e-1)" "unprognostic (2.36e-2)" "unprognostic (4.85e-2)" "unprognostic (6.93e-2)" "unprognostic (1.77e-3)" "unprognostic (1.03e-3)" "unprognostic (2.91e-3)" "unprognostic (1.75e-1)" "unprognostic (3.84e-2)" "unprognostic (2.56e-2)" "unprognostic (1.82e-3)" "prognostic favorable (1.00e-4)" "unprognostic (5.91e-2)" "unprognostic (4.57e-2)" "unprognostic (8.57e-2)" "unprognostic (1.38e-1)" 24.8 21.7 19.6 29.4 20.3 29.5 23.4 22.1 22.9 21.0 17.8 31.2 29.5 25.9 23.9 29.1 27.0 18.5 25.4 20.8 20.7 28.8 33.8 18.7 36.7 18.8 18.7 27.1 23.0 41.5 6.0 40.3 19.0 28.3 26.4 52.5 21.0 25.9 46.6 25.7 27.4 31.0 19.8 32.6 23.8 22.0 20.4 29.1 27.4 39.5 37.7 32.1 10.1 21.6 63.6 72.9 78.5 104.7 31.4 50.2 111.5 58.0 60.1 96.9 51.5 106.9 54.9 102.9 65.2 61.1 47.7 69.8 108.2 89.7 139.0 41.3 63.3 63.2 37.3 92.2 39.4 95.0 37.9 30.0 74.8 95.6 112.3 57.5 76.4 68.5 153.4 22.7 73.1 129.4 92.4 96.8 102.5 71.8 56.7 119.9 44.5 55.0 81.9 48.4 73.0 48.6 130.5 48.7 54.0 72.3 108.4 76.8 55.7 66.9 60.2 39.4 62.2 38.8 53.7 272.3 44.5 64.6 73.2 29.0 77.3 15.6 46.1 61.9 58.0 60.6 148.0 53.9 92.6 59.7 82.9 49.6 742.4 65.9 58.6 30.7 57.3 97.3 19.6 20.3 22.1 22.9 20.8 20.7 18.8 18.7 19.0 19.8 20.4 21.6 21.3 54.5 50.0 26.4 51.5 51.5 46.1 25.8 54.1 25.1 27.6 28.6 66.6 25.8 45.2 27.6 29.2 106.9 38.1 25.8 31.3 29.0 63.3 31.0 35.8 30.4 28.9 42.5 39.3 25.1 73.4 40.1 35.7 42.1 58.0 38.7 21.0 37.2 31.4 20.2 38.9 28.1 16.2 34.8 33.4 116.6 23.6 40.6 24.9 41.2 52.6 23.7 32.0 49.8 35.8 23.6 23.9 22.6 50.8 48.6 30.4 45.0 90.7 52.7 26.3 58.4 34.3 35.0 29.5 54.5 49.6 60.9 42.5 33.6 40.6 45.2 USP11 UHX1 ENSG00000102226 "Ubiquitin specific peptidase 11" P51784 X 47232866-47248328 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Bipolar cells: 203.6;Horizontal cells: 139.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003103, HPA037536" Enhanced Supported Supported Nucleoplasm,Cytosol "Intracellular and membrane" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 56: Bipolar cells - Visual perception" Nucleoplasm Cytosol "HPA003103: AB_10671088, HPA037536: AB_10672904" "unprognostic (1.60e-1)" "unprognostic (2.77e-3)" "unprognostic (5.84e-2)" "prognostic unfavorable (2.95e-4)" "unprognostic (3.08e-2)" "unprognostic (2.02e-1)" "unprognostic (6.11e-3)" "unprognostic (9.21e-2)" "unprognostic (3.18e-2)" "unprognostic (3.52e-1)" "unprognostic (3.29e-3)" "unprognostic (3.74e-2)" "prognostic favorable (4.13e-5)" "unprognostic (3.14e-2)" "unprognostic (9.23e-2)" "unprognostic (9.51e-2)" "unprognostic (7.11e-2)" 25.5 32.8 117.7 23.7 118.7 11.2 26.8 41.5 116.3 51.2 30.0 33.9 11.5 47.0 23.6 18.2 49.9 24.5 45.5 113.1 148.1 33.3 12.7 30.9 30.1 69.8 78.3 76.4 27.1 36.6 103.7 24.9 93.9 33.4 14.1 84.8 21.4 38.7 32.4 18.5 25.5 35.9 65.4 29.3 24.9 46.2 122.8 42.6 52.2 29.6 28.9 36.9 31.7 79.8 45.6 70.7 117.6 81.0 43.4 28.5 33.0 34.0 52.5 65.6 73.3 67.4 36.7 29.9 26.1 60.5 70.5 53.5 94.7 24.0 56.4 47.1 73.5 34.7 52.9 61.4 50.7 39.2 70.7 42.1 9.8 69.1 29.3 37.3 26.7 68.9 26.6 3.9 51.8 70.0 77.8 43.4 89.2 24.3 62.5 86.1 114.3 25.1 32.4 60.9 66.8 114.4 62.6 12.4 37.7 73.9 26.0 23.0 28.2 56.0 58.0 79.3 39.6 54.3 36.2 51.3 34.3 48.8 50.8 63.9 9.1 19.9 55.4 19.6 48.3 53.1 24.5 54.3 11.9 53.1 36.6 76.3 5.5 56.4 24.3 53.2 35.0 46.0 117.7 118.7 41.5 116.3 113.1 148.1 69.8 78.3 93.9 65.4 122.8 79.8 13.6 22.4 17.7 25.8 53.5 13.6 42.2 30.9 21.6 203.6 13.0 23.5 24.2 7.2 31.5 33.1 56.3 20.9 52.2 9.4 50.9 18.3 26.4 28.2 26.3 22.5 35.4 18.3 43.3 10.2 15.0 41.3 22.4 28.3 45.7 56.6 22.1 8.2 13.4 139.7 63.7 8.7 28.5 12.0 16.3 41.0 29.5 17.9 28.4 19.7 17.5 96.2 23.7 25.1 24.8 12.5 7.9 42.2 48.1 18.6 4.7 15.2 46.4 63.4 26.3 57.2 40.2 18.3 87.8 11.9 6.5 16.3 44.6 34.2 8.9 26.0 USP12 USP12L1 ENSG00000152484 "Ubiquitin specific peptidase 12" O75317 13 27066156-27171811 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Langerhans cells: 153.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007288, HPA059492" Uncertain Approved Nucleoplasm NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 41: Macrophages - Immune response" Nucleoplasm "HPA007288: AB_1080531, HPA059492: " "unprognostic (6.72e-3)" "unprognostic (2.63e-3)" "unprognostic (1.04e-1)" "unprognostic (2.34e-2)" "unprognostic (1.22e-1)" "unprognostic (5.85e-2)" "unprognostic (1.79e-1)" "unprognostic (3.39e-1)" "unprognostic (8.38e-2)" "unprognostic (8.77e-2)" "unprognostic (2.20e-1)" "unprognostic (3.06e-2)" "unprognostic (1.22e-2)" "unprognostic (1.40e-1)" "unprognostic (2.91e-1)" "unprognostic (6.77e-2)" "unprognostic (1.73e-1)" 20.4 13.6 21.0 20.9 22.0 75.7 15.3 21.6 26.7 13.1 15.5 35.6 18.2 13.2 15.1 17.0 13.5 17.9 14.4 23.7 22.2 24.8 34.9 23.6 29.4 18.9 24.8 14.7 15.3 16.5 13.8 17.7 19.5 14.0 25.5 38.0 10.2 12.1 13.1 24.0 24.3 18.6 21.0 17.2 17.7 15.5 22.2 12.2 16.1 15.9 26.4 21.8 13.5 21.8 24.9 15.3 28.6 14.9 18.8 23.8 10.2 34.1 23.9 18.5 13.7 27.7 37.8 35.1 16.6 27.0 44.9 15.0 18.9 19.8 39.4 57.0 16.1 54.3 19.2 19.6 23.6 31.8 36.5 14.9 28.3 21.0 23.9 23.4 43.3 23.8 18.4 16.5 38.9 14.4 19.6 42.0 20.5 31.5 26.7 22.1 36.5 8.3 36.3 17.3 31.5 19.0 29.3 24.2 28.2 35.5 11.4 30.4 51.6 19.3 18.6 41.6 31.4 12.6 15.0 24.6 32.4 18.5 22.0 0.0 0.5 2.2 0.5 0.5 0.9 1.2 0.9 0.8 0.6 1.6 0.6 0.6 0.5 0.9 0.8 1.1 1.4 0.4 21.0 22.0 21.6 26.7 23.7 22.2 18.9 24.8 19.5 21.0 22.2 21.8 54.2 28.9 29.9 19.6 42.1 91.6 29.4 7.0 34.7 23.8 30.6 24.0 23.4 17.2 9.1 23.9 39.6 15.4 26.5 47.0 29.4 12.8 19.2 29.1 26.4 42.0 20.9 60.6 37.0 16.3 7.0 34.2 23.9 68.9 13.3 15.7 21.4 23.3 14.0 28.6 29.0 27.5 10.2 20.8 153.8 10.7 7.8 47.8 39.2 42.2 33.6 13.8 9.2 43.7 65.0 24.4 37.4 6.4 37.1 34.0 34.3 21.3 12.2 32.1 32.9 114.7 42.8 2.7 12.9 23.1 79.0 10.9 27.2 9.3 24.1 40.6 USP13 IsoT-3 ENSG00000058056 "Ubiquitin specific peptidase 13" Q92995 3 179653032-179804366 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Autophagy, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 149.2;tongue: 108.9" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 208.5;Inhibitory neurons: 52.2;Theca cells: 58.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "MAIT T-cell: 15.6" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "HDLM-2: 93.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004827 Enhanced Approved Nucleoplasm,Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 54: Cardiomyocytes - Muscle contraction" "Nucleoplasm, Cytosol" "HPA004827: AB_1080497" "unprognostic (1.00e-2)" "unprognostic (2.09e-1)" "unprognostic (5.82e-2)" "unprognostic (7.14e-2)" "unprognostic (9.94e-2)" "unprognostic (3.96e-2)" "prognostic unfavorable (2.40e-5)" "unprognostic (1.76e-1)" "unprognostic (4.55e-2)" "unprognostic (7.79e-2)" "unprognostic (1.69e-3)" "unprognostic (2.22e-2)" "prognostic unfavorable (3.46e-6)" "unprognostic (4.93e-2)" "unprognostic (9.79e-2)" "unprognostic (3.38e-2)" "prognostic unfavorable (3.06e-4)" 6.2 11.9 3.9 2.8 13.6 1.5 5.3 8.6 12.0 3.3 0.0 2.9 1.2 5.7 3.4 4.0 3.4 4.5 42.5 3.7 4.7 3.0 4.6 5.4 3.6 11.3 10.5 12.5 4.1 4.0 5.8 2.6 12.7 4.3 2.2 7.1 6.2 2.7 149.2 2.2 1.9 6.3 6.4 2.1 1.7 6.0 8.1 2.4 9.7 108.9 3.5 3.5 2.2 34.4 27.6 11.3 20.0 14.8 8.9 14.1 11.6 18.6 17.4 23.7 18.8 17.1 9.6 35.6 18.0 17.2 27.6 2.6 21.4 9.1 26.4 93.3 14.8 9.0 23.6 14.4 6.3 26.5 1.1 10.5 3.0 18.8 18.5 9.1 16.6 11.9 4.7 43.0 15.7 15.0 22.5 3.0 17.9 1.3 13.1 29.3 20.2 27.4 11.7 7.9 13.0 14.5 14.1 16.9 7.2 5.4 37.0 12.7 24.1 28.6 27.6 23.7 64.1 29.5 21.2 78.3 13.0 15.0 27.2 0.1 0.3 0.0 2.6 0.5 15.6 3.2 1.8 3.8 1.5 0.9 1.2 1.3 0.0 0.0 0.7 4.5 0.7 1.3 3.9 13.6 8.6 12.0 3.7 4.7 11.3 10.5 12.7 6.4 8.1 34.4 45.0 9.6 35.9 14.0 5.3 2.5 1.9 1.4 0.6 13.7 7.1 5.2 208.5 5.7 5.4 1.8 6.2 10.7 5.6 1.4 15.6 1.1 2.6 13.9 11.4 10.1 9.6 5.5 23.2 4.4 2.4 12.0 4.1 2.5 2.5 35.5 22.1 7.6 4.3 16.8 52.2 2.9 0.0 4.8 3.5 3.6 9.3 5.0 14.2 16.9 1.7 7.0 3.1 36.2 42.5 1.0 12.2 9.4 4.5 4.4 0.1 2.7 3.7 10.2 13.1 17.8 12.0 6.1 2.8 4.8 1.6 5.1 4.1 58.8 4.5 1.4 USP14 TGT ENSG00000101557 "Ubiquitin specific peptidase 14" P54578 18 158383-214629 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Immunity, Innate immunity, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001308 Approved Supported "Plasma membrane,Cytosol" NA NA 2700000 "Cluster 15: NK-cells - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" "Plasma membrane, Cytosol" "HPA001308: AB_1080499" "unprognostic (2.21e-1)" "unprognostic (4.05e-2)" "unprognostic (1.90e-1)" "unprognostic (2.59e-3)" "unprognostic (6.04e-2)" "prognostic unfavorable (7.81e-5)" "prognostic unfavorable (4.30e-5)" "unprognostic (5.14e-2)" "unprognostic (5.00e-2)" "prognostic favorable (7.91e-4)" "unprognostic (1.64e-2)" "unprognostic (2.39e-1)" "unprognostic (1.51e-3)" "unprognostic (2.58e-1)" "unprognostic (1.55e-1)" "unprognostic (2.20e-2)" "unprognostic (3.76e-2)" 26.0 21.5 19.9 22.7 21.3 23.9 17.0 20.1 22.9 15.5 13.9 17.8 13.9 17.0 23.8 24.0 14.6 14.6 24.8 21.0 24.5 23.4 25.3 15.1 21.6 25.4 21.7 13.3 13.0 21.2 14.3 26.5 25.7 29.7 19.3 15.5 15.2 19.6 55.6 15.4 12.4 24.7 20.3 13.8 15.1 17.9 26.0 21.8 20.4 36.4 31.3 22.6 15.3 23.3 91.6 75.4 62.7 64.5 60.7 60.0 109.6 115.5 64.9 118.9 110.5 98.9 48.7 133.1 86.6 99.1 114.4 50.9 125.1 91.7 134.9 38.7 59.0 72.5 46.0 78.1 60.5 184.1 70.8 48.4 69.1 122.3 69.5 55.0 93.5 65.9 106.2 99.3 119.1 76.2 105.2 52.4 59.4 56.0 83.5 87.8 78.6 98.0 88.7 79.9 71.8 60.1 120.7 59.2 52.5 68.0 58.2 51.5 103.9 138.7 104.3 128.8 170.6 62.3 125.7 130.9 80.0 77.3 88.4 10.7 18.1 13.8 27.9 25.8 33.6 21.1 27.5 29.5 25.6 16.4 26.7 26.2 1.5 39.3 20.5 18.7 28.6 19.4 19.9 21.3 20.1 22.9 21.0 24.5 25.4 21.7 25.7 20.3 26.0 23.3 40.0 22.4 40.4 27.7 52.7 58.6 53.3 42.0 51.8 58.0 33.4 23.5 44.9 31.5 48.3 44.1 31.3 92.3 58.1 22.5 45.0 60.6 70.9 44.9 56.3 43.1 22.1 102.0 58.8 54.0 71.8 49.0 43.8 80.8 34.8 47.1 28.2 45.4 50.9 116.1 54.4 22.5 46.8 31.5 53.4 21.6 31.7 45.5 35.6 33.7 48.8 39.4 46.4 35.2 74.8 75.8 16.9 45.9 72.7 71.4 15.2 56.0 40.2 50.3 0.0 49.6 51.4 34.1 68.1 57.9 52.4 135.6 55.0 58.9 33.5 51.8 USP15 "KIAA0529, UNPH4" ENSG00000135655 "Ubiquitin specific peptidase 15" Q9Y4E8 12 62260338-62417431 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 176.2" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 297.9" "Lineage enriched" "Detected in all" 5 "granulocytes: 297.9" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006237, HPA006428, HPA071014" Approved Supported "Nucleoplasm,Nuclear bodies,Cytosol" NA NA 300000 "Cluster 1: Neutrophils - Mixed function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 1: K-562 - Erythropoiesis" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Cytosol "Nucleoplasm, Nuclear bodies" "HPA006237: AB_1080502, HPA006428: AB_2667588, HPA071014: AB_2686333" "unprognostic (8.18e-2)" "unprognostic (3.22e-1)" "unprognostic (9.63e-2)" "unprognostic (2.09e-1)" "unprognostic (1.10e-1)" "unprognostic (2.75e-1)" "prognostic unfavorable (8.04e-4)" "unprognostic (6.59e-2)" "unprognostic (7.70e-3)" "unprognostic (2.19e-1)" "unprognostic (2.47e-1)" "unprognostic (4.51e-2)" "prognostic unfavorable (1.58e-5)" "unprognostic (9.28e-2)" "unprognostic (5.81e-3)" "unprognostic (1.11e-2)" "unprognostic (1.26e-1)" 29.0 21.6 4.5 29.4 4.8 176.2 22.9 12.3 6.7 17.6 10.2 18.0 13.8 14.6 9.2 19.7 17.8 13.7 19.8 5.2 5.5 14.9 27.2 31.5 33.3 6.0 5.4 26.7 19.7 14.9 13.9 18.4 5.7 14.3 16.7 45.8 19.7 8.3 35.5 29.9 24.6 12.6 4.6 44.3 18.8 30.2 5.5 26.5 17.1 14.8 24.9 18.1 19.4 8.0 18.3 16.5 14.2 17.7 25.7 25.1 27.0 29.0 21.2 22.3 16.1 19.6 21.6 15.5 16.6 17.8 10.1 18.5 18.4 23.1 27.6 18.5 15.0 25.2 15.1 14.1 18.8 35.6 61.8 15.0 19.2 27.2 20.7 20.7 26.1 16.3 80.8 36.0 20.0 23.5 26.4 19.3 25.4 16.5 24.0 17.2 19.1 32.3 17.9 22.8 17.9 8.9 30.9 21.6 17.3 17.4 34.7 18.8 37.2 21.2 22.2 32.0 18.2 16.4 24.0 21.9 25.7 26.7 23.5 163.4 60.0 64.3 13.5 31.1 14.9 28.5 19.6 14.0 23.7 20.5 23.5 13.8 297.9 14.7 26.8 26.6 58.8 26.1 4.5 4.8 12.3 6.7 5.2 5.5 6.0 5.4 5.7 4.6 5.5 8.0 57.1 38.5 36.4 68.6 130.3 58.8 40.8 26.2 40.5 54.9 32.3 28.1 74.9 21.5 48.9 23.9 110.5 31.7 142.5 50.2 11.7 36.4 172.2 26.3 46.5 45.4 42.0 248.3 124.8 41.5 43.3 52.5 57.6 38.9 88.6 53.5 21.0 45.3 46.2 42.1 104.2 33.2 12.2 101.3 97.6 172.0 61.8 120.6 53.4 135.9 195.8 25.6 90.6 100.0 108.8 55.1 47.6 29.3 94.3 36.0 30.9 25.9 31.9 151.5 39.5 66.1 60.5 83.7 43.3 49.3 77.0 65.8 130.0 27.0 29.5 60.8 USP16 Ubp-M ENSG00000156256 "Ubiquitin specific peptidase 16" Q9Y5T5 21 29024629-29054488 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 514.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021140 Supported Approved Nucleoplasm,Cytosol NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 23: Testis - Cell cycle regulation" "Cluster 2: Karpas-707 - Immune response" "Cluster 29: Early spermatids - Spermatogenesis" "Nucleoplasm, Cytosol" "HPA021140: AB_1858668" "unprognostic (6.06e-2)" "unprognostic (3.14e-1)" "unprognostic (1.10e-2)" "unprognostic (1.47e-1)" "unprognostic (5.92e-2)" "unprognostic (5.79e-3)" "unprognostic (1.92e-1)" "unprognostic (8.99e-2)" "unprognostic (5.78e-2)" "unprognostic (7.40e-2)" "unprognostic (8.73e-2)" "unprognostic (8.65e-2)" "unprognostic (6.68e-2)" "unprognostic (2.84e-1)" "unprognostic (1.55e-1)" "unprognostic (2.84e-2)" "unprognostic (1.54e-1)" 27.0 23.0 18.8 23.4 23.2 29.3 27.4 21.3 20.4 22.7 19.1 24.6 25.1 25.2 25.2 25.2 19.9 20.4 29.3 17.5 20.5 22.1 30.7 20.9 27.9 20.5 20.8 22.3 26.0 34.3 16.7 24.2 21.7 25.7 26.4 42.3 24.7 23.6 34.7 19.9 22.8 22.6 20.2 21.9 23.4 25.7 20.3 30.0 33.8 37.5 32.3 27.1 14.1 27.5 59.9 23.4 36.5 33.0 25.4 41.5 34.2 56.9 37.9 38.5 36.4 29.5 38.3 60.5 16.8 54.8 58.7 26.5 45.6 41.5 50.1 58.6 48.4 80.9 27.3 33.1 37.6 80.3 43.0 35.9 42.9 50.3 46.4 28.7 37.5 33.9 67.7 103.8 45.3 27.3 49.7 29.3 39.2 48.4 29.9 33.0 89.7 69.6 31.7 42.5 39.4 41.9 36.8 58.1 51.1 24.9 40.2 54.2 38.0 44.8 55.7 41.8 59.3 87.8 129.3 62.5 46.8 57.3 45.6 37.4 24.1 33.6 36.3 24.9 28.6 40.7 34.1 33.6 23.1 46.0 36.9 35.8 23.5 31.5 34.0 36.2 38.9 17.2 18.8 23.2 21.3 20.4 17.5 20.5 20.5 20.8 21.7 20.2 20.3 27.5 60.3 86.6 91.9 27.4 114.4 57.2 132.5 68.9 55.2 161.0 65.8 58.7 84.2 64.3 83.1 53.3 89.6 81.7 108.2 90.2 133.1 77.9 514.9 85.9 82.6 55.0 82.6 40.8 18.2 119.9 79.7 68.3 55.0 107.7 141.8 61.5 45.7 86.2 59.9 72.3 27.6 100.4 44.7 62.0 53.1 117.0 87.7 69.4 62.2 25.3 117.3 94.1 96.8 28.1 47.3 94.0 99.2 86.9 106.8 100.1 74.8 91.8 94.1 183.5 59.2 133.4 83.2 100.4 82.4 68.4 64.4 162.0 105.3 72.8 90.6 141.9 USP17L2 DUB3 ENSG00000223443 "Ubiquitin specific peptidase 17 like family member 2" Q6R6M4 8 12137168-12139077 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" "unprognostic (2.01e-1)" 0.0 0.0 0.3 0.0 0.5 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.5 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.5 0.0 0.6 0.2 0.5 0.0 0.2 0.3 0.0 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L22 ENSG00000248933 "Ubiquitin specific peptidase 17 like family member 22" D6RA61 4 9267619-9269211 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "Evidence at transcript level" "Tissue enriched" "Detected in single" 18 "brain: 1.8" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "Cluster 65: Brain - Ion transport" "HPA045642: AB_2679403" 0.0 0.0 1.4 0.0 0.7 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.6 0.0 0.0 0.0 0.0 1.3 0.1 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.7 0.0 1.2 0.8 0.6 1.3 0.1 1.8 0.1 1.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L24 ENSG00000232264 "Ubiquitin specific peptidase 17 like family member 24" Q0WX57 4 9325165-9326757 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L25 ENSG00000230430 "Ubiquitin specific peptidase 17 like family member 25" Q0WX57 4 9329911-9331503 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L26 ENSG00000229579 "Ubiquitin specific peptidase 17 like family member 26" Q0WX57 4 9334658-9336250 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L27 ENSG00000235780 "Ubiquitin specific peptidase 17 like family member 27" Q0WX57 4 9344148-9345740 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L28 ENSG00000231051 "Ubiquitin specific peptidase 17 like family member 28" Q0WX57 4 9348893-9350485 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L29 ENSG00000231637 "Ubiquitin specific peptidase 17 like family member 29" Q0WX57 4 9353638-9355230 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L30 ENSG00000228856 "Ubiquitin specific peptidase 17 like family member 30" Q0WX57 4 9363129-9364721 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L5 ENSG00000227140 "Ubiquitin specific peptidase 17 like family member 5" A8MUK1 4 9339403-9340995 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP18 ENSG00000184979 "Ubiquitin specific peptidase 18" Q9UMW8 22 18150170-18177397 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal tubular cells: 46.9;Extravillous trophoblasts: 31.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+ SV40 Large T+: 181.8;BJ hTERT+ SV40 Large T+ RasG12V: 196.2" HPA044768 Uncertain Supported Vesicles,Cytosol NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 64: Macrophages - Immune response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 38: Extravillous trophoblasts - Unknown function" Cytosol Vesicles "HPA044768: AB_10963697" "unprognostic (2.06e-1)" "unprognostic (3.55e-2)" "unprognostic (1.57e-2)" "unprognostic (5.04e-3)" "unprognostic (1.40e-2)" "unprognostic (5.42e-2)" "unprognostic (3.29e-2)" "unprognostic (5.11e-3)" "unprognostic (1.81e-1)" "unprognostic (1.79e-3)" "unprognostic (9.77e-2)" "unprognostic (1.47e-1)" "unprognostic (4.29e-3)" "unprognostic (2.58e-1)" "unprognostic (2.77e-2)" "unprognostic (2.28e-2)" "unprognostic (8.38e-2)" 10.8 5.0 3.6 5.1 3.8 8.1 8.3 3.3 4.5 4.0 4.0 5.0 6.0 3.2 7.8 4.0 7.3 6.6 4.4 3.7 3.9 5.9 23.6 7.9 9.2 5.1 3.9 2.9 4.2 3.6 5.7 5.7 4.2 5.3 4.4 0.7 14.0 2.5 3.8 3.4 6.7 4.0 7.0 11.0 7.2 9.7 4.1 15.0 7.3 5.5 6.5 4.0 3.6 3.7 14.4 14.6 4.2 18.2 18.2 13.5 18.4 7.3 17.5 181.8 196.2 2.2 20.1 0.2 10.8 4.0 57.5 4.9 21.6 6.4 6.2 64.4 29.4 28.3 1.9 27.0 2.1 6.9 25.7 6.0 2.5 12.8 0.0 1.0 40.8 20.6 1.4 1.7 1.8 24.9 33.4 16.7 12.7 15.6 11.0 13.1 28.4 0.0 3.6 12.4 15.2 11.9 8.8 15.0 71.9 16.3 9.9 6.6 66.7 1.3 3.5 4.1 7.5 3.4 45.4 0.2 16.3 17.1 10.5 3.2 3.9 8.3 8.5 11.0 10.7 5.3 7.2 11.1 1.8 3.4 8.2 9.6 0.7 13.3 8.6 3.3 13.1 5.3 3.6 3.8 3.3 4.5 3.7 3.9 5.1 3.9 4.2 7.0 4.1 3.7 9.7 9.6 4.8 0.7 2.5 1.7 4.5 5.7 2.2 0.2 8.4 8.3 1.4 8.6 6.9 0.0 0.0 4.6 3.0 6.2 46.9 5.9 1.6 20.1 2.5 8.4 3.0 1.3 0.5 11.1 31.9 7.1 4.1 6.3 0.0 8.5 11.0 5.5 8.7 0.0 0.6 3.5 6.1 6.3 0.8 1.7 3.7 3.8 3.6 0.0 1.6 5.1 8.2 2.0 0.3 13.4 3.2 7.2 2.3 2.5 5.4 8.0 12.2 0.3 6.6 8.0 2.5 10.9 1.0 4.0 1.0 1.5 5.0 5.5 2.8 2.9 USP19 "KIAA0891, ZMYND9" ENSG00000172046 "Ubiquitin specific peptidase 19" O94966 3 49108046-49120938 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 16: U-266 - Nucleosome" "Cluster 10: Non-specific - Unknown function" "unprognostic (3.23e-2)" "unprognostic (2.12e-1)" "unprognostic (5.91e-2)" "unprognostic (1.37e-1)" "unprognostic (1.92e-2)" "unprognostic (3.90e-3)" "unprognostic (2.99e-2)" "unprognostic (3.00e-3)" "unprognostic (2.69e-1)" "unprognostic (3.65e-2)" "unprognostic (2.31e-2)" "unprognostic (1.26e-1)" "prognostic favorable (7.05e-9)" "unprognostic (2.99e-1)" "unprognostic (2.11e-1)" "unprognostic (1.72e-3)" "unprognostic (7.54e-2)" 20.3 25.5 16.4 19.4 18.7 26.8 19.6 19.0 18.6 21.9 24.4 26.2 22.4 24.3 19.1 19.7 24.3 15.5 26.8 17.4 16.8 18.9 18.6 17.7 21.5 19.0 17.5 22.8 21.2 31.0 17.5 16.5 17.9 19.4 15.9 14.3 29.6 24.4 75.6 26.5 21.9 18.9 16.7 22.9 21.6 20.8 18.4 27.4 23.6 45.0 16.8 23.3 19.6 19.5 20.2 26.3 28.6 42.1 36.8 24.1 38.7 23.1 26.1 35.1 28.7 28.7 27.3 41.6 22.2 24.4 36.2 24.1 40.3 29.1 16.0 32.7 32.1 42.5 56.4 22.8 36.1 45.7 40.5 33.8 22.7 36.9 24.1 25.9 24.2 33.8 30.8 28.4 18.9 23.9 42.6 43.0 58.2 27.4 44.1 19.4 24.3 45.7 22.3 37.4 16.5 51.4 33.3 38.1 34.9 26.1 26.0 55.4 21.8 24.5 30.5 36.7 33.7 77.7 97.1 38.0 32.8 34.3 32.6 9.7 3.7 5.3 4.5 3.6 4.2 2.8 3.7 5.2 4.6 2.9 3.3 3.9 7.5 2.9 4.4 1.9 2.7 4.3 16.4 18.7 19.0 18.6 17.4 16.8 19.0 17.5 17.9 16.7 18.4 19.5 7.8 12.8 14.5 10.4 7.2 6.2 3.8 8.5 8.6 12.7 8.7 7.4 13.1 5.7 9.9 7.3 18.8 9.6 9.2 17.1 5.9 7.7 3.6 14.8 8.7 7.6 9.1 10.3 8.4 7.8 5.3 7.7 14.3 9.5 2.5 8.1 7.9 13.6 9.0 13.5 8.0 11.6 10.2 8.7 4.7 4.9 13.1 6.8 3.6 2.8 6.5 8.7 3.1 8.0 7.7 11.5 13.9 12.4 7.4 4.2 16.3 7.7 14.9 11.4 13.1 12.3 11.1 16.2 13.2 9.1 5.4 13.5 8.0 9.8 13.4 3.1 USP2 UBP41 ENSG00000036672 "Ubiquitin specific peptidase 2" O75604 11 119355215-119381711 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Biological rhythms, Cell cycle, Myogenesis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 168.3" "Group enriched" "Detected in many" 5 "Early spermatids: 460.0;Late spermatids: 1094.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "K-562: 14.5;U-266/70: 56.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006777, HPA007222" Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 54: Non-specific - Microtubule organization" "Cluster 29: U-266 - Adaptive immune response" "Cluster 31: Spermatids - Spermatogenesis" Cytosol "Plasma membrane" "HPA006777: AB_1080507, HPA007222: AB_1080505" "unprognostic (6.83e-2)" "unprognostic (2.02e-2)" "unprognostic (5.54e-2)" "unprognostic (1.37e-2)" "unprognostic (1.25e-1)" "unprognostic (7.46e-3)" "unprognostic (1.00e-1)" "unprognostic (5.27e-2)" "unprognostic (1.24e-1)" "unprognostic (5.24e-3)" "unprognostic (8.02e-3)" "unprognostic (7.33e-2)" "prognostic favorable (3.09e-11)" "unprognostic (1.58e-1)" "unprognostic (1.20e-1)" "unprognostic (1.96e-2)" "unprognostic (2.66e-2)" 7.0 13.4 11.9 1.6 22.6 1.9 4.1 18.8 19.0 6.0 32.7 10.2 13.9 5.2 5.7 9.8 11.6 2.3 73.5 18.6 9.4 53.4 18.9 3.4 0.1 12.0 13.1 6.2 18.1 24.2 18.9 1.3 7.7 4.1 6.0 76.2 7.6 3.0 168.3 12.8 17.4 6.8 8.2 0.6 6.2 86.5 15.1 0.6 3.8 62.8 0.6 4.5 4.8 17.5 6.0 0.5 0.9 3.2 0.1 0.2 1.3 0.7 0.4 0.0 0.6 6.1 0.8 10.2 1.8 1.1 1.4 1.0 7.9 2.9 0.2 7.2 1.0 2.8 4.4 12.5 2.7 0.0 2.8 0.9 0.6 0.7 2.0 1.3 0.6 7.6 14.5 0.8 1.7 4.1 0.0 0.6 1.6 2.0 1.3 0.1 2.1 1.5 4.6 0.3 11.9 3.6 3.4 2.6 0.7 1.7 8.8 6.2 0.0 0.0 1.5 0.8 1.0 56.9 13.5 0.2 0.1 2.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.9 22.6 18.8 19.0 18.6 9.4 12.0 13.1 7.7 8.2 15.1 17.5 0.6 3.2 2.7 10.7 0.6 2.4 5.3 1.5 1.2 75.2 3.3 2.4 85.2 7.2 6.1 5.5 95.9 0.5 1.6 25.5 113.5 3.1 460.0 39.0 3.0 3.6 0.0 0.4 15.7 1.6 0.9 7.4 2.0 8.4 0.0 2.0 2.2 23.0 17.2 10.1 11.6 2.0 0.0 1.3 2.9 1094.1 6.5 2.1 0.0 1.9 0.0 49.7 0.0 8.0 12.5 1.2 11.8 7.2 0.1 1.1 41.3 41.6 35.0 140.0 19.7 43.3 24.0 50.5 16.5 12.9 4.0 1.4 1.3 0.5 2.6 2.9 USP20 KIAA1003 ENSG00000136878 "Ubiquitin specific peptidase 20" Q9Y2K6 9 129834698-129881828 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Endocytosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "JURKAT: 95.9;K-562: 60.2;MOLT-4: 56.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006287, HPA007008" Uncertain Supported Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 58: T-cells - T-cell receptor" "Nucleoplasm, Plasma membrane, Cytosol" "HPA006287: AB_1080510, HPA007008: " "unprognostic (2.64e-2)" "prognostic favorable (8.01e-4)" "prognostic unfavorable (2.48e-4)" "prognostic favorable (4.01e-4)" "unprognostic (4.69e-1)" "unprognostic (1.89e-2)" "unprognostic (2.25e-1)" "unprognostic (2.55e-3)" "unprognostic (1.24e-1)" "unprognostic (7.89e-2)" "prognostic favorable (1.54e-7)" "unprognostic (2.09e-1)" "prognostic favorable (5.65e-5)" "unprognostic (1.76e-2)" "unprognostic (1.20e-1)" "unprognostic (1.19e-2)" "unprognostic (1.24e-2)" 8.1 12.0 8.7 13.5 8.0 22.6 8.3 4.8 8.7 12.5 2.5 13.6 8.2 12.5 4.2 7.9 12.1 7.7 7.5 7.8 10.6 7.6 7.4 8.4 18.3 10.2 9.1 13.5 10.9 8.4 18.4 6.7 10.0 14.8 4.9 6.7 11.4 13.2 10.9 12.1 12.5 8.2 5.4 13.9 9.9 10.0 8.9 32.3 18.7 7.5 11.8 14.9 10.1 6.5 6.0 5.8 10.0 13.4 12.8 10.8 14.1 9.5 7.9 7.1 4.9 4.7 6.5 8.1 8.0 9.3 8.0 14.7 6.0 6.7 2.9 43.4 7.9 14.9 17.0 3.3 8.8 14.2 10.6 9.6 9.8 9.3 7.0 12.4 7.7 95.9 60.2 9.9 4.4 15.9 56.4 33.6 7.9 12.7 13.6 9.4 11.2 14.0 5.5 6.5 2.2 11.0 11.0 13.9 9.1 5.9 14.4 19.9 11.5 7.8 3.5 10.5 6.3 9.7 15.3 5.7 15.5 18.6 7.4 1.0 1.9 5.4 8.6 1.5 9.1 3.7 8.7 8.3 2.6 3.4 9.8 8.9 2.8 10.0 1.5 2.1 11.5 6.3 8.7 8.0 4.8 8.7 7.8 10.6 10.2 9.1 10.0 5.4 8.9 6.5 3.0 9.6 6.9 16.3 9.2 2.8 2.2 2.5 4.0 7.8 6.4 8.0 7.7 4.3 3.0 1.8 4.2 5.9 9.4 6.2 3.9 2.4 2.1 4.1 6.3 4.3 8.4 12.8 17.0 4.0 2.5 4.6 8.2 5.7 1.3 6.8 6.4 6.1 3.3 10.1 21.1 4.6 4.1 1.6 3.8 3.3 6.2 6.0 3.6 11.2 3.1 5.3 11.3 9.5 14.3 2.7 5.0 4.9 6.7 3.0 4.1 2.9 5.0 6.3 0.0 4.3 5.7 12.1 6.0 4.8 2.0 6.2 19.3 2.9 5.2 1.6 USP21 "USP16, USP23" ENSG00000143258 "Ubiquitin specific peptidase 21" Q9UK80 1 161159450-161165723 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 16.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA028397 Uncertain Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 80: Striated muscle - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 59: Non-specific - Transcription" Cytosol "Nucleoplasm, Plasma membrane" "HPA028397: AB_10603227" "unprognostic (9.17e-2)" "unprognostic (1.44e-1)" "unprognostic (3.95e-2)" "prognostic unfavorable (7.05e-4)" "unprognostic (1.22e-2)" "unprognostic (1.26e-2)" "prognostic unfavorable (1.68e-4)" "unprognostic (5.35e-2)" "unprognostic (6.73e-2)" "unprognostic (2.76e-2)" "unprognostic (3.87e-3)" "unprognostic (1.31e-2)" "prognostic unfavorable (9.50e-6)" "unprognostic (2.45e-1)" "unprognostic (3.28e-1)" "unprognostic (2.13e-2)" "prognostic favorable (3.35e-5)" 12.2 15.3 19.6 11.9 20.7 15.0 14.3 18.5 22.8 19.4 18.3 17.6 13.6 18.2 12.0 16.4 28.0 12.0 13.0 19.4 18.4 14.5 10.8 13.1 16.1 19.2 19.7 23.2 16.4 17.1 15.7 13.2 18.7 17.7 11.0 12.9 16.5 20.3 20.9 20.8 15.9 12.6 17.3 17.8 16.4 14.2 20.1 18.4 18.5 17.7 14.0 17.6 16.8 22.1 12.5 20.6 26.9 26.2 21.1 17.5 16.5 9.1 14.6 24.2 18.9 19.4 23.3 16.0 14.6 11.2 15.1 20.7 17.6 17.5 13.2 30.8 30.0 19.3 34.1 15.3 15.2 17.4 13.4 14.8 23.0 16.6 23.9 27.1 17.3 35.0 28.4 21.6 15.6 22.6 30.7 26.9 25.2 24.3 26.1 28.8 9.0 26.5 14.4 14.9 24.2 31.5 17.2 17.2 13.9 20.1 37.3 27.5 10.1 16.9 14.8 11.9 15.3 42.9 36.5 23.9 15.3 14.7 15.5 15.2 10.0 17.1 12.6 6.4 14.6 11.0 11.5 13.2 10.8 11.3 13.1 12.3 8.4 13.3 7.6 10.8 12.3 11.0 19.6 20.7 18.5 22.8 19.4 18.4 19.2 19.7 18.7 17.3 20.1 22.1 4.5 0.0 3.7 5.2 6.5 1.5 1.8 2.4 16.5 5.0 4.9 4.1 3.9 8.6 2.9 1.8 6.2 4.9 3.6 3.6 1.9 2.0 1.0 6.3 5.7 4.4 5.4 10.7 2.4 2.3 2.3 5.1 9.2 3.7 2.5 4.5 5.3 2.1 2.2 0.0 2.7 4.0 4.1 4.8 0.8 1.0 5.0 2.1 1.8 1.9 1.2 3.3 5.2 2.0 4.6 2.0 2.4 4.1 7.8 2.7 3.5 2.5 9.5 5.2 6.6 2.0 5.2 5.3 3.2 10.7 1.4 3.1 5.6 3.1 4.1 1.5 USP22 "KIAA1063, USP3L" ENSG00000124422 "Ubiquitin specific peptidase 22" Q9UPT9 17 20999596-21043760 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044980 Supported Approved "Nuclear speckles" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 52: Non-specific - Transcription" "Nuclear speckles" "HPA044980: AB_10794503" "unprognostic (7.24e-2)" "unprognostic (5.38e-2)" "unprognostic (7.67e-2)" "unprognostic (6.19e-2)" "unprognostic (4.72e-1)" "unprognostic (1.11e-2)" "prognostic unfavorable (9.66e-4)" "unprognostic (2.17e-2)" "unprognostic (7.81e-2)" "unprognostic (6.37e-2)" "unprognostic (1.07e-3)" "unprognostic (5.68e-2)" "prognostic favorable (1.53e-7)" "unprognostic (8.95e-2)" "unprognostic (1.93e-1)" "unprognostic (2.91e-1)" "unprognostic (1.79e-2)" 40.7 66.8 91.2 40.3 93.7 53.0 42.5 72.0 90.5 55.3 44.8 48.8 33.6 63.7 48.2 40.7 57.3 40.0 79.8 93.1 112.3 49.5 44.1 46.3 48.3 71.7 78.1 75.6 48.0 68.2 65.2 39.3 85.8 50.2 35.2 57.1 36.3 48.2 108.6 40.3 39.5 54.0 72.4 45.1 49.8 29.3 120.3 63.9 57.0 81.2 50.2 42.3 35.4 68.4 106.9 189.7 179.9 155.5 102.7 105.9 85.9 120.2 91.8 105.6 89.3 220.0 46.9 145.4 112.5 185.2 71.3 111.7 176.7 143.1 157.1 70.0 122.8 120.8 121.5 107.9 121.3 134.2 101.0 117.4 83.9 119.9 125.1 119.8 134.1 93.3 139.7 51.4 151.6 109.5 189.8 63.7 93.1 125.5 61.9 206.2 284.5 99.2 97.7 153.9 86.3 177.8 154.9 63.5 124.9 488.4 106.4 78.0 171.0 107.4 140.8 111.3 164.1 55.0 79.6 476.2 109.0 70.3 169.4 5.5 9.6 10.0 7.9 7.6 7.9 8.0 8.1 7.8 9.2 9.9 10.7 10.2 9.9 7.1 9.7 7.6 6.1 6.0 91.2 93.7 72.0 90.5 93.1 112.3 71.7 78.1 85.8 72.4 120.3 68.4 46.6 41.7 48.8 31.6 47.9 33.0 43.8 33.8 38.7 97.6 80.3 63.8 23.8 45.8 41.5 60.7 93.8 51.4 36.6 59.3 23.5 51.6 36.0 59.3 75.3 56.1 88.2 43.7 53.1 59.0 37.5 51.0 57.6 68.7 30.4 86.5 76.8 68.5 38.1 117.8 66.0 48.8 30.5 53.8 36.1 51.2 51.0 31.7 35.6 43.1 42.2 55.4 28.8 38.7 50.6 69.6 40.3 71.8 36.6 62.2 33.4 48.9 37.4 59.1 13.1 58.6 52.2 15.9 19.7 49.6 29.1 65.8 33.4 77.9 53.3 53.5 USP24 KIAA1057 ENSG00000162402 "Ubiquitin specific peptidase 24" Q9UPU5 1 55066359-55215364 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in many" 4 "Oligodendrocyte precursor cells: 552.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026723, HPA028428, HPA067124" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 1: K-562 - Erythropoiesis" "Cluster 68: Oligodendrocytes - Mixed function" Nucleoplasm Cytosol "HPA026723: AB_10599851, HPA028428: AB_10600991, HPA067124: AB_2685785" "unprognostic (2.28e-1)" "unprognostic (9.81e-3)" "unprognostic (4.70e-3)" "unprognostic (4.86e-3)" "unprognostic (9.31e-3)" "unprognostic (4.84e-3)" "prognostic unfavorable (1.34e-7)" "unprognostic (2.04e-1)" "unprognostic (6.93e-2)" "unprognostic (2.98e-1)" "unprognostic (5.08e-2)" "unprognostic (1.86e-1)" "unprognostic (8.12e-2)" "unprognostic (1.79e-1)" "unprognostic (6.42e-2)" "unprognostic (4.12e-2)" "unprognostic (1.64e-1)" 16.6 8.2 13.4 14.2 13.3 56.7 13.4 25.3 13.6 9.4 13.2 12.0 8.3 10.7 9.2 9.4 9.9 9.0 12.7 12.6 14.7 15.7 15.3 10.6 22.1 13.5 13.1 16.5 11.4 20.3 12.8 9.6 14.6 10.2 13.3 17.2 12.8 9.6 47.9 13.6 12.6 9.8 12.8 18.6 12.3 8.4 13.6 21.9 9.2 36.6 20.9 10.4 9.2 14.2 32.5 17.4 21.3 11.6 27.2 23.5 24.6 14.0 17.5 19.6 20.3 25.0 11.1 25.9 15.1 26.1 40.1 25.6 28.5 23.6 30.5 27.2 17.4 51.5 40.2 29.6 16.1 36.0 38.6 21.0 20.6 30.0 33.7 19.0 18.2 25.7 48.5 10.6 26.6 7.6 21.9 19.1 31.4 15.5 21.0 22.3 27.1 11.3 34.6 21.4 18.7 13.1 23.8 16.8 21.1 32.3 11.7 17.5 24.7 17.9 17.3 21.7 22.6 13.2 10.6 33.2 16.9 29.4 16.3 5.4 1.3 1.7 2.8 1.1 1.7 3.0 2.2 2.2 1.2 3.4 1.9 2.5 1.4 2.3 1.5 6.9 1.3 0.7 13.4 13.3 25.3 13.6 12.6 14.7 13.5 13.1 14.6 12.8 13.6 14.2 20.4 16.0 20.0 92.4 27.7 14.9 8.4 5.6 9.1 14.0 13.4 10.2 37.7 10.0 13.0 12.9 73.0 4.2 42.6 11.1 0.0 10.3 0.7 11.9 15.1 16.1 17.3 37.4 84.5 10.2 7.8 11.9 21.4 15.0 12.7 18.2 12.1 11.9 9.7 38.7 100.4 16.2 8.2 19.2 18.8 2.5 11.8 18.6 10.6 87.1 19.6 7.0 15.5 552.4 115.2 11.8 11.4 7.9 18.1 12.7 8.3 5.9 10.0 16.9 6.6 18.0 13.5 7.7 7.1 13.9 17.2 1.5 21.8 9.8 16.0 12.1 USP25 USP21 ENSG00000155313 "Ubiquitin specific peptidase 25" Q9UHP3 21 15730025-15880069 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 120.9" "Cell type enhanced" "Detected in all" "Early spermatids: 166.7;Excitatory neurons: 148.0;Late spermatids: 192.8;Oligodendrocyte precursor cells: 150.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018297, HPA024142" Approved Supported Cytosol NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 30: Epithelial cell lines - Translation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "HPA018297: AB_1858672, HPA024142: AB_1858673" "unprognostic (6.35e-2)" "unprognostic (1.50e-1)" "unprognostic (6.90e-2)" "unprognostic (6.29e-2)" "unprognostic (1.39e-1)" "unprognostic (2.88e-2)" "unprognostic (3.91e-2)" "unprognostic (1.65e-1)" "unprognostic (1.44e-2)" "unprognostic (1.38e-1)" "unprognostic (2.33e-2)" "unprognostic (1.40e-1)" "unprognostic (8.24e-3)" "unprognostic (2.34e-3)" "unprognostic (4.50e-2)" "unprognostic (1.61e-1)" "unprognostic (2.32e-2)" 25.8 12.9 13.4 16.8 20.1 26.9 17.6 12.6 17.2 18.1 12.3 15.3 12.6 26.8 18.7 21.4 16.8 12.4 28.1 16.2 4.2 21.4 20.2 24.0 20.1 4.7 4.3 14.1 15.9 14.3 7.6 29.4 4.8 17.9 16.1 9.5 17.5 24.6 120.9 13.1 13.3 36.4 4.4 19.5 13.1 54.5 4.9 25.6 15.5 75.1 19.3 15.5 17.3 11.9 31.2 23.1 21.5 3.2 38.7 57.5 25.3 22.0 21.8 16.0 20.1 20.5 17.4 33.6 31.5 34.9 24.3 16.4 16.7 29.1 22.0 33.5 19.1 27.5 23.5 15.8 64.3 36.6 12.1 37.6 34.7 25.8 74.0 41.7 57.0 30.0 35.9 61.4 29.1 13.0 42.1 7.1 26.6 12.5 20.3 31.8 20.0 25.8 43.5 8.3 4.7 12.8 31.4 26.2 20.9 25.9 14.0 21.3 54.6 24.8 16.0 26.2 12.5 17.7 11.9 26.8 16.0 16.1 18.6 0.0 1.4 1.9 1.8 1.4 2.0 1.6 1.5 3.2 1.2 1.1 1.4 2.1 2.9 1.1 1.3 1.3 2.2 0.8 13.4 20.1 12.6 17.2 16.2 4.2 4.7 4.3 4.8 4.4 4.9 11.9 30.4 57.7 29.5 47.3 21.7 17.1 18.8 9.7 15.9 6.2 17.4 11.8 55.7 15.7 24.2 22.0 4.2 39.0 21.4 20.3 5.9 9.4 166.7 24.0 19.0 19.7 9.6 21.5 148.0 13.4 8.4 19.4 17.9 34.6 6.3 14.4 17.9 18.0 13.3 5.0 98.4 12.8 8.2 24.2 16.0 192.8 19.0 24.2 16.0 86.2 23.7 4.0 23.7 150.3 72.4 13.4 8.4 12.8 15.9 22.0 11.9 15.1 23.4 6.7 19.7 26.1 17.2 11.2 5.8 22.7 19.2 33.1 26.9 18.5 11.6 20.4 USP26 ENSG00000134588 "Ubiquitin specific peptidase 26" Q9BXU7 X 133024631-133097109 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 13 "Spermatogonia: 4.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA000424, HPA027310, HPA079124" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" Nucleoplasm Cytosol "HPA000424: , HPA027310: , HPA079124: " "unprognostic (7.92e-4)" "unprognostic (3.59e-2)" "unprognostic (1.99e-2)" "unprognostic (2.08e-1)" 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 USP27X USP27 ENSG00000273820 "Ubiquitin specific peptidase 27 X-linked" A6NNY8 X 49879484-49882558 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 14.4" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 19.2;Alveolar cells type 2: 15.5;Bipolar cells: 15.8;Cytotrophoblasts: 44.5;Syncytiotrophoblasts: 26.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "SuSa: 12.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA077264 Approved Nucleoplasm,Vesicles NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 12: NES - Nervous system development" "Cluster 47: Cytotrophoblasts - Unknown function" Vesicles Nucleoplasm "HPA077264: AB_2686831" "unprognostic (4.12e-2)" "unprognostic (9.58e-3)" "unprognostic (2.29e-1)" "unprognostic (4.66e-2)" "unprognostic (1.98e-1)" "unprognostic (1.74e-1)" "prognostic unfavorable (6.14e-4)" "unprognostic (3.10e-3)" "unprognostic (3.91e-2)" "unprognostic (1.31e-2)" "prognostic favorable (9.31e-4)" "unprognostic (5.37e-2)" "unprognostic (7.45e-3)" "unprognostic (1.19e-1)" "unprognostic (1.12e-1)" "unprognostic (2.01e-2)" "unprognostic (2.58e-1)" 1.6 2.5 6.0 1.3 6.2 0.5 2.0 8.0 5.8 3.0 3.1 3.2 1.0 3.9 2.9 1.6 3.5 1.6 1.8 5.3 14.4 2.7 1.8 2.7 1.7 4.9 8.4 6.3 2.6 3.0 7.3 11.7 5.9 3.0 1.4 3.8 1.6 2.8 4.4 2.1 2.1 2.8 3.6 1.8 2.4 1.3 10.5 2.6 2.4 2.1 1.7 3.0 2.2 4.4 1.6 3.8 4.2 4.8 3.8 3.1 3.6 1.6 2.6 1.8 1.4 6.9 1.6 0.9 1.6 4.2 6.0 2.6 6.0 4.0 2.6 2.0 3.1 1.6 1.1 6.2 2.6 0.5 3.4 4.4 2.7 2.6 2.6 4.4 2.5 4.2 3.4 1.5 2.9 3.7 2.5 1.2 4.8 2.7 2.7 2.7 3.7 0.3 2.9 1.4 1.1 3.2 3.4 3.0 4.0 12.9 3.5 1.1 1.9 2.1 4.3 3.8 0.7 1.6 0.4 0.6 2.5 1.4 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 6.0 6.2 8.0 5.8 5.3 14.4 4.9 8.4 5.9 3.6 10.5 4.4 3.5 19.2 15.5 0.7 2.5 2.9 4.5 0.3 2.2 15.8 1.9 2.7 2.6 0.0 7.5 0.0 0.0 44.5 1.4 1.7 5.9 1.5 0.1 2.1 4.1 5.2 4.2 0.0 2.9 0.7 3.6 2.7 1.1 2.1 2.5 4.0 2.5 1.9 4.0 5.0 3.3 1.3 0.0 0.6 1.0 0.3 2.1 1.2 0.0 0.0 1.5 8.3 0.0 3.5 0.8 1.2 0.5 3.4 0.5 3.3 0.5 2.9 13.2 2.5 6.6 2.5 2.6 0.2 1.3 0.9 2.3 26.1 2.0 8.8 1.6 1.7 USP28 KIAA1515 ENSG00000048028 "Ubiquitin specific peptidase 28" Q96RU2 11 113797874-113875570 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 62.7;skeletal muscle: 68.3;tongue: 66.5" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 152.2;Excitatory neurons: 57.0;NK-cells: 73.2" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebellum: 20.1" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006778, HPA006779" Enhanced Supported "Nucleoplasm,Nuclear bodies" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 38: Heart - Muscle contraction" "Cluster 12: NES - Nervous system development" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm "Nuclear bodies" "HPA006778: AB_1080520, HPA006779: AB_1080517" "unprognostic (2.54e-1)" "unprognostic (2.72e-1)" "unprognostic (2.99e-2)" "unprognostic (3.72e-2)" "unprognostic (5.51e-2)" "unprognostic (2.30e-1)" "unprognostic (9.73e-3)" "unprognostic (3.00e-1)" "unprognostic (2.04e-3)" "unprognostic (1.82e-3)" "unprognostic (3.17e-2)" "unprognostic (1.19e-1)" "unprognostic (5.11e-2)" "unprognostic (2.06e-2)" "unprognostic (9.03e-2)" "unprognostic (1.35e-3)" "unprognostic (5.03e-2)" 5.8 6.7 3.2 9.5 4.3 5.8 10.4 20.1 9.5 21.1 0.6 10.4 9.6 11.5 11.3 9.6 9.8 7.7 62.7 4.6 1.8 9.9 11.3 7.5 15.6 2.1 1.7 14.1 8.2 15.5 7.4 8.0 3.4 11.3 11.7 27.1 12.0 14.2 68.3 7.0 10.4 13.1 1.2 13.8 9.2 9.2 1.9 9.0 10.1 66.5 15.5 9.8 8.4 5.3 18.3 20.2 26.7 35.4 21.3 20.9 18.8 13.2 18.0 17.5 29.7 30.2 25.6 24.2 29.3 18.0 40.1 35.1 37.9 24.8 24.1 27.1 17.2 12.9 13.8 16.3 13.0 16.8 12.4 12.6 18.5 20.2 23.8 25.4 32.0 11.9 22.7 15.3 18.5 9.3 12.9 27.1 32.0 33.6 14.4 31.3 37.1 29.4 19.3 17.8 11.6 12.6 31.4 10.7 10.1 82.7 25.8 5.8 17.1 19.2 28.3 17.8 13.8 10.4 15.9 20.1 1.9 32.1 12.8 0.2 5.0 3.4 23.2 3.7 12.1 15.5 5.7 16.8 6.4 12.3 3.8 13.1 1.4 28.6 6.4 1.9 9.2 10.3 3.2 4.3 20.1 9.5 4.6 1.8 2.1 1.7 3.4 1.2 1.9 5.3 7.3 9.6 8.8 18.3 17.8 1.7 7.3 9.9 13.6 18.7 9.7 9.8 152.2 5.7 9.9 5.5 18.8 4.4 32.1 3.3 5.9 6.7 1.7 6.6 11.6 7.9 4.9 2.5 57.0 3.9 4.7 12.2 11.7 8.7 1.3 18.9 7.5 8.8 4.4 5.0 34.1 9.6 4.1 6.5 2.5 2.0 6.8 7.4 1.8 10.3 8.2 10.3 73.2 29.1 21.3 3.5 5.3 13.9 21.7 7.1 7.3 7.1 14.6 21.5 6.6 10.3 11.0 15.8 11.4 7.7 2.0 1.1 18.6 9.0 8.9 5.8 USP29 ENSG00000131864 "Ubiquitin specific peptidase 29" Q9HBJ7 19 57119138-57131926 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "testis: 4.9" "Group enriched" "Detected in some" 8 "Collecting duct cells: 1.8;Early spermatids: 2.2;Spermatocytes: 5.1;Spermatogonia: 1.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected" "Not detected" HPA076515 Enhanced NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 21: Non-specific - Transcription" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA076515: " "unprognostic (1.32e-1)" 0.1 0.0 0.9 0.0 0.5 1.8 0.0 2.1 0.6 0.0 1.0 0.1 0.1 0.2 0.0 0.2 0.1 0.2 0.5 1.0 1.0 0.1 0.1 0.2 0.4 1.9 0.9 0.3 1.3 0.0 0.0 0.2 0.8 0.1 0.1 0.6 0.7 0.0 0.3 1.4 0.0 0.0 0.8 0.2 0.4 4.9 0.8 0.0 0.3 0.0 0.1 0.3 0.0 2.0 0.0 0.2 0.2 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.3 0.9 0.2 0.0 0.0 0.3 0.0 0.5 0.2 0.3 0.4 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.2 0.0 0.3 0.0 0.1 0.3 0.2 0.0 0.2 0.0 0.6 0.5 0.2 0.1 0.1 0.1 0.3 0.2 0.3 0.4 0.3 0.1 0.0 0.0 0.4 0.1 0.3 0.1 0.2 0.0 1.3 0.3 0.3 0.2 0.2 0.1 0.2 0.1 0.1 0.1 0.2 0.1 0.1 1.1 0.3 0.1 0.6 0.1 0.2 0.9 0.5 2.1 0.6 1.0 1.0 1.9 0.9 0.8 0.8 0.8 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 5.1 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.2 USP3 ENSG00000140455 "Ubiquitin specific peptidase 3" Q9Y6I4 15 63504511-63594640 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, DNA damage, Ubl conjugation pathway" "Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in all" 4 "cerebellum: 36.4" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA053275, HPA060513, HPA077975" Supported "Nucleoplasm,Midbody ring" "Intracellular and membrane" Yes No "Cluster 1: Neutrophils - Mixed function" "Cluster 50: Non-specific - Ribosome" "Cluster 15: RT4 - Unknown function" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Nucleoplasm "Midbody ring" "HPA053275: AB_2682096, HPA060513: AB_2684299, HPA077975: AB_2732365" "unprognostic (4.63e-3)" "unprognostic (2.71e-1)" "unprognostic (7.88e-2)" "unprognostic (3.33e-2)" "unprognostic (2.16e-2)" "unprognostic (6.03e-2)" "unprognostic (6.26e-2)" "unprognostic (4.52e-2)" "unprognostic (1.62e-2)" "unprognostic (2.36e-1)" "unprognostic (3.54e-2)" "unprognostic (4.87e-2)" "unprognostic (1.17e-1)" "unprognostic (8.61e-2)" "unprognostic (2.78e-1)" "unprognostic (6.21e-2)" "prognostic favorable (1.38e-4)" 12.7 8.2 5.8 5.4 7.0 21.4 11.2 36.4 5.9 11.7 15.4 13.4 6.5 12.9 4.7 10.9 10.9 5.4 6.0 5.3 6.3 10.1 8.2 13.2 6.5 6.9 6.9 16.2 18.9 3.1 6.2 2.7 7.6 10.4 5.6 6.3 12.4 6.0 10.0 14.6 13.9 4.5 5.3 17.6 15.7 5.3 8.6 7.4 9.1 3.6 6.4 12.4 11.9 7.5 10.4 21.0 12.1 8.1 5.5 7.6 8.2 6.7 9.6 7.1 5.8 6.6 13.1 8.7 15.3 9.3 3.6 12.0 11.6 11.1 5.6 12.2 5.8 10.4 8.6 9.8 6.8 6.4 11.4 11.3 7.8 7.7 10.6 8.9 12.4 17.3 9.5 9.0 3.3 5.2 11.0 8.8 16.2 13.7 5.3 22.2 8.4 11.3 4.5 23.8 9.6 9.5 3.3 13.0 6.7 7.8 5.5 9.5 13.4 7.2 16.9 3.3 10.3 9.3 24.4 18.2 7.4 13.8 7.5 120.0 84.7 12.7 24.8 66.0 28.4 34.1 34.3 26.0 59.8 34.8 34.0 25.2 169.1 19.8 65.4 13.1 28.1 45.2 5.8 7.0 36.4 5.9 5.3 6.3 6.9 6.9 7.6 5.3 8.6 7.5 23.6 38.5 69.2 76.7 63.4 52.6 34.3 24.8 23.3 31.4 27.9 20.3 9.2 25.8 41.4 16.5 12.5 19.8 48.4 37.6 41.1 41.0 21.6 37.8 32.8 26.0 43.8 15.8 11.2 37.2 57.3 28.3 39.8 74.6 27.1 64.5 11.4 24.0 24.8 13.5 40.0 35.4 30.5 78.4 109.6 77.4 15.8 74.5 42.7 75.9 101.8 25.9 41.2 80.4 40.6 39.8 35.6 18.4 69.7 40.6 33.2 28.3 33.3 17.9 13.1 25.3 34.5 14.8 40.3 33.9 59.0 34.1 64.6 40.1 40.6 37.6 USP30 "FLJ40511, MGC10702" ENSG00000135093 "Ubiquitin specific peptidase 30" Q70CQ3 12 109023089-109088023 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 52.7;Oligodendrocytes: 41.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016952 Approved NA NA "Cluster 44: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 25: Spermatids - Spermatogenesis" "HPA016952: AB_1858680" "unprognostic (2.34e-1)" "unprognostic (1.57e-2)" "unprognostic (7.04e-2)" "unprognostic (9.91e-2)" "unprognostic (2.48e-1)" "unprognostic (5.89e-2)" "unprognostic (1.91e-1)" "unprognostic (3.60e-3)" "unprognostic (1.98e-1)" "unprognostic (4.96e-2)" "unprognostic (5.07e-2)" "unprognostic (1.07e-1)" "prognostic favorable (5.23e-6)" "unprognostic (2.49e-1)" "unprognostic (1.23e-1)" "unprognostic (1.12e-1)" "unprognostic (1.02e-3)" 8.4 8.8 2.9 7.3 6.0 10.7 6.5 4.2 5.4 6.6 1.9 10.2 11.4 7.8 4.7 5.6 8.0 5.9 6.8 3.3 6.9 9.1 16.3 6.8 8.8 5.2 4.3 12.4 8.6 14.4 4.2 5.1 5.5 6.8 8.4 10.7 7.7 6.7 10.0 6.6 11.1 6.2 3.0 7.9 6.5 13.8 5.0 6.3 8.2 8.7 4.5 4.3 3.3 14.1 5.3 4.1 10.7 9.2 7.3 8.3 5.9 5.9 7.8 6.8 5.9 4.9 3.9 13.6 4.8 5.9 6.1 5.6 9.4 6.3 7.7 16.0 11.7 4.2 3.8 7.1 7.8 8.7 4.6 10.1 7.4 5.9 6.0 17.5 8.0 13.8 6.8 6.1 5.9 6.3 13.8 5.0 3.2 6.3 11.3 14.7 7.6 8.1 5.4 6.4 9.7 8.6 8.0 5.6 6.3 7.8 14.5 6.8 5.5 5.9 3.3 5.9 3.7 16.0 14.4 19.3 6.5 5.0 6.9 14.0 8.4 16.2 17.5 14.0 20.2 17.3 14.7 16.8 5.6 17.0 15.2 14.1 5.1 23.3 11.7 15.2 14.4 7.4 2.9 6.0 4.2 5.4 3.3 6.9 5.2 4.3 5.5 3.0 5.0 14.1 3.9 0.0 4.6 10.7 2.5 2.0 2.2 4.1 6.2 9.1 4.8 4.1 8.6 10.0 5.6 5.5 8.4 5.7 3.4 14.3 0.0 4.7 27.3 3.6 3.8 3.6 6.7 5.7 18.8 5.7 4.2 4.4 1.5 3.2 0.0 11.8 4.2 18.3 5.7 6.7 22.7 8.4 0.0 3.5 1.4 52.7 3.7 2.2 1.8 7.5 3.5 6.9 4.1 16.6 41.8 5.3 5.6 3.8 6.7 1.9 13.3 7.3 5.2 14.9 13.1 5.2 3.5 26.1 5.6 4.7 3.3 7.3 3.4 5.0 9.9 2.7 USP31 KIAA1203 ENSG00000103404 "Ubiquitin specific peptidase 31" Q70CQ4 16 23061406-23149270 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 31.2" "Cell type enhanced" "Detected in many" "Oligodendrocytes: 198.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006937 Uncertain Approved Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 30: Epithelial cell lines - Translation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "HPA006937: AB_1080523" "unprognostic (6.45e-2)" "unprognostic (2.42e-1)" "unprognostic (1.08e-1)" "unprognostic (4.43e-3)" "unprognostic (1.24e-1)" "unprognostic (1.28e-1)" "unprognostic (1.23e-1)" "unprognostic (1.29e-1)" "unprognostic (1.03e-1)" "unprognostic (2.52e-1)" "unprognostic (6.15e-2)" "unprognostic (2.01e-1)" "prognostic unfavorable (4.41e-5)" "unprognostic (5.59e-2)" "unprognostic (3.75e-1)" "unprognostic (3.07e-1)" "unprognostic (1.98e-3)" 5.5 2.9 7.5 2.0 23.4 4.3 6.7 18.9 13.0 12.9 0.7 4.2 1.7 11.0 3.8 6.0 5.3 1.9 9.2 10.0 10.5 3.6 5.6 6.1 1.8 22.3 20.3 2.2 4.3 5.5 5.7 3.9 21.3 7.5 2.3 3.2 4.6 4.1 8.9 11.2 2.6 7.5 11.3 1.6 2.6 11.8 20.6 2.6 3.0 8.4 2.5 7.5 7.9 31.2 12.0 12.4 3.5 4.9 6.2 4.8 3.3 4.1 3.7 5.1 6.1 7.9 7.1 4.0 4.2 5.1 8.3 15.2 8.7 15.9 8.4 2.9 3.5 1.6 7.4 16.7 7.8 4.2 4.3 4.1 13.5 9.5 21.8 1.9 9.3 3.9 4.9 12.0 7.1 8.0 2.0 3.5 6.9 3.9 3.8 9.9 9.8 7.9 7.7 17.5 9.3 6.0 6.3 12.4 3.6 3.9 5.0 9.2 5.5 10.3 7.6 5.3 11.2 3.9 7.0 4.2 7.4 5.5 4.2 0.0 0.1 0.1 0.1 0.0 0.3 0.0 0.1 0.2 0.1 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.2 0.0 7.5 23.4 18.9 13.0 10.0 10.5 22.3 20.3 21.3 11.3 20.6 31.2 25.9 6.4 3.7 11.1 2.2 66.8 62.7 35.5 44.9 13.7 7.6 19.8 13.6 7.2 10.9 5.5 2.1 13.8 3.6 2.7 0.0 7.0 4.8 20.6 12.8 17.6 4.8 8.2 59.2 8.6 7.5 6.9 2.0 13.2 1.3 23.7 7.5 27.7 4.7 0.0 49.6 3.5 12.2 3.5 10.8 10.4 7.8 5.0 7.2 32.8 3.1 4.0 3.1 31.7 198.7 7.9 2.0 4.5 2.8 32.0 1.5 11.6 17.6 8.1 19.7 8.8 11.2 24.2 57.1 17.4 26.6 7.5 2.9 4.4 6.4 23.9 USP32 "NY-REN-60, USP10" ENSG00000170832 "Ubiquitin specific peptidase 32" Q8NFA0 17 60177327-60422470 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 102.1" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 241.8;Inhibitory neurons: 113.1;Oligodendrocytes: 268.9;Rod photoreceptor cells: 136.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "plasmacytoid DC: 59.2" "Group enriched" "Detected in all" 10 "dendritic cells: 59.2;granulocytes: 29.4" "Cell line enhanced" "Detected in all" "MCF7: 171.4" "Low region specificity" "Detected in all" HPA044365 Approved Approved "Golgi apparatus,Cytosol" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 77: Retina - Visual perception" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 9: Photoreceptor cells - Phototransduction" "Golgi apparatus" Cytosol "HPA044365: AB_2678914" "unprognostic (4.10e-2)" "unprognostic (3.38e-2)" "unprognostic (3.57e-2)" "prognostic unfavorable (1.50e-4)" "unprognostic (2.15e-1)" "unprognostic (4.33e-2)" "unprognostic (1.90e-3)" "unprognostic (2.33e-2)" "unprognostic (2.24e-1)" "unprognostic (3.93e-1)" "unprognostic (6.49e-2)" "unprognostic (2.78e-1)" "unprognostic (2.82e-1)" "unprognostic (1.97e-1)" "unprognostic (7.23e-2)" "unprognostic (8.35e-2)" "unprognostic (4.16e-2)" 16.1 21.8 13.6 15.0 27.8 32.1 14.1 23.2 23.6 12.4 25.2 13.0 9.5 10.3 6.8 21.7 10.7 11.8 17.4 14.3 22.8 20.2 26.6 20.7 10.5 22.2 25.0 10.0 12.5 19.2 11.9 13.2 24.8 10.8 11.4 58.8 12.9 11.2 40.8 21.0 10.5 13.7 18.1 18.5 12.2 102.1 22.3 14.4 20.6 29.2 11.6 13.1 14.7 44.4 32.6 38.2 19.0 30.8 44.8 45.3 17.2 26.4 41.9 34.5 45.8 18.6 20.0 19.4 21.5 50.0 56.1 16.3 33.1 36.9 61.5 16.8 13.9 39.7 31.8 19.5 44.1 31.7 33.6 39.6 24.6 49.9 45.2 33.5 38.6 24.4 42.9 17.1 41.1 171.4 32.3 21.3 21.7 29.6 18.8 15.8 51.6 11.5 33.1 24.5 13.1 19.1 22.9 6.0 33.8 32.1 27.4 41.3 32.6 49.7 54.9 33.1 23.5 16.2 37.4 19.6 24.6 23.6 33.4 14.5 4.3 16.5 2.0 3.7 1.4 3.0 1.4 1.7 8.5 2.2 1.0 1.9 29.4 1.3 4.6 59.2 2.6 2.1 13.6 27.8 23.2 23.6 14.3 22.8 22.2 25.0 24.8 18.1 22.3 44.4 8.0 6.4 16.4 58.8 12.5 26.9 13.3 5.8 11.4 17.3 9.2 7.6 8.2 10.0 10.1 5.5 241.8 5.1 12.6 8.5 3.9 11.3 95.0 9.0 9.9 9.8 8.3 44.2 92.3 7.5 8.4 12.6 15.8 11.6 11.4 18.5 12.5 12.0 18.5 13.5 113.1 5.6 6.1 29.7 41.3 33.3 13.1 25.1 5.4 101.2 28.0 10.4 24.7 70.4 268.9 9.6 11.4 5.7 8.3 10.3 7.4 4.6 7.0 136.4 26.3 11.9 9.1 92.7 14.9 11.2 21.9 4.9 10.9 8.5 5.5 8.2 USP33 "KIAA1097, VDU1" ENSG00000077254 "Ubiquitin specific peptidase 33" Q8TEY7 1 77695987-77759852 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Endocytosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Inhibitory neurons: 159.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005719 Uncertain Supported "Nucleoplasm,Golgi apparatus" NA NA "Cluster 42: Non-specific - Transcription" "Cluster 6: Brain - Smell perception" "Cluster 36: HEL - Hemostasis" "Cluster 50: Fibroblasts - ECM organization" "Nucleoplasm, Golgi apparatus" "HPA005719: AB_10601708" "unprognostic (2.31e-3)" "unprognostic (2.73e-2)" "unprognostic (1.04e-2)" "unprognostic (2.36e-1)" "unprognostic (9.19e-3)" "unprognostic (1.88e-3)" "unprognostic (1.22e-2)" "unprognostic (6.06e-2)" "unprognostic (2.48e-1)" "unprognostic (2.25e-1)" "unprognostic (2.67e-1)" "unprognostic (3.59e-1)" "unprognostic (5.36e-3)" "unprognostic (4.89e-2)" "unprognostic (5.76e-2)" "unprognostic (2.19e-1)" "unprognostic (2.02e-2)" 40.7 31.2 31.5 24.6 40.4 34.5 34.3 52.0 49.7 24.2 37.3 24.3 25.4 28.0 26.8 21.6 22.5 26.3 21.7 35.4 31.8 31.1 25.4 26.2 28.1 28.6 24.9 29.3 19.5 35.0 20.9 28.0 30.8 28.8 25.2 49.1 25.2 22.9 18.0 24.3 26.9 24.1 22.3 26.0 24.4 25.4 28.6 27.1 30.4 20.7 26.0 22.9 20.0 55.5 42.4 18.8 64.1 44.2 90.0 78.3 54.8 45.3 42.9 54.0 60.1 25.4 35.5 31.4 41.2 44.3 88.2 32.1 47.4 31.1 65.7 28.8 36.6 111.1 44.6 22.2 56.0 37.8 26.8 58.3 23.9 52.4 37.9 51.9 48.7 28.0 43.9 26.3 41.2 16.1 34.9 38.0 62.2 32.6 37.2 33.0 67.7 22.2 51.0 41.1 53.8 41.2 31.9 41.5 64.2 54.3 23.1 41.2 41.2 49.4 34.4 50.1 43.2 21.0 28.4 30.4 37.3 44.5 25.4 67.3 22.5 31.8 21.0 22.6 21.7 20.5 20.6 21.7 17.5 22.3 24.5 21.9 30.5 19.2 30.1 18.4 20.7 16.7 31.5 40.4 52.0 49.7 35.4 31.8 28.6 24.9 30.8 22.3 28.6 55.5 40.2 44.8 40.9 66.3 35.1 17.2 18.8 21.2 32.5 56.7 25.7 22.1 39.9 22.8 25.5 35.0 58.4 25.1 48.8 35.9 9.8 20.8 4.3 54.8 37.8 31.8 35.5 50.9 149.3 15.4 19.0 39.6 43.3 54.6 23.4 43.1 28.2 23.1 19.0 62.2 159.0 28.6 22.4 30.8 20.7 5.5 35.8 35.1 23.2 75.9 38.7 31.4 37.0 98.0 138.5 19.6 27.8 32.0 42.4 22.9 33.2 25.6 37.3 44.5 19.7 34.9 35.6 39.8 30.1 28.4 16.3 11.9 41.0 39.2 24.8 21.8 USP34 "KIAA0570, KIAA0729" ENSG00000115464 "Ubiquitin specific peptidase 34" Q70CQ2 2 61187463-61471087 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 310.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA025815, HPA070764" Uncertain Approved Nucleoplasm NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 52: Non-specific - Transcription" Nucleoplasm "HPA025815: AB_1858681, HPA070764: AB_2686308" "unprognostic (4.04e-2)" "unprognostic (8.21e-3)" "unprognostic (5.08e-2)" "unprognostic (3.14e-2)" "unprognostic (4.13e-2)" "unprognostic (1.43e-2)" "unprognostic (1.04e-1)" "unprognostic (2.66e-1)" "unprognostic (1.47e-1)" "unprognostic (2.90e-2)" "unprognostic (8.91e-2)" "unprognostic (4.62e-2)" "unprognostic (9.58e-2)" "unprognostic (1.66e-1)" "unprognostic (2.53e-1)" "unprognostic (6.34e-2)" "unprognostic (7.01e-2)" 32.2 36.0 49.9 21.7 53.9 37.7 35.6 57.7 58.3 36.1 59.9 47.0 14.8 38.4 54.4 35.8 33.3 21.1 33.7 49.7 53.5 43.3 34.8 36.4 44.1 52.1 51.8 43.4 32.4 35.1 45.0 17.4 52.3 38.6 26.8 77.5 27.2 32.4 53.9 41.4 40.8 27.9 50.3 45.8 36.3 45.1 54.5 47.8 32.2 36.8 45.1 36.9 32.8 56.8 43.6 29.9 38.9 40.3 71.8 48.1 32.4 26.3 37.1 23.0 21.7 43.0 16.3 102.2 27.0 56.9 24.3 23.4 30.9 34.4 42.6 36.7 24.4 61.6 29.5 69.6 60.2 46.1 37.8 52.9 43.6 41.9 62.1 55.7 49.0 28.8 42.7 32.2 51.5 40.6 30.6 66.6 26.3 43.9 23.9 32.4 46.5 27.7 67.9 52.2 31.9 34.0 40.5 30.1 48.3 49.4 16.0 33.2 43.6 36.1 48.2 21.5 34.7 37.0 19.7 103.6 33.8 42.5 31.7 2.1 1.2 1.6 3.8 1.1 3.5 2.6 2.6 2.9 1.0 3.1 2.9 3.9 1.8 3.1 2.8 3.2 2.5 1.4 49.9 53.9 57.7 58.3 49.7 53.5 52.1 51.8 52.3 50.3 54.5 56.8 64.5 64.1 68.3 193.6 82.8 61.1 54.2 40.3 46.7 139.7 54.0 46.6 46.0 48.6 54.6 33.1 250.2 33.5 87.3 46.0 9.8 41.4 133.5 59.9 66.9 59.3 48.6 53.2 256.6 33.6 23.8 53.0 73.9 70.6 32.3 78.0 31.8 38.9 21.6 107.7 240.4 37.8 59.0 45.4 48.6 138.0 56.8 56.0 40.9 212.7 55.2 60.0 87.6 232.2 310.0 49.9 41.1 67.0 69.9 79.9 38.3 23.4 44.1 178.1 26.3 78.2 63.9 95.8 115.9 53.1 61.4 53.4 70.5 74.7 35.6 69.9 USP35 KIAA1372 ENSG00000118369 "Ubiquitin specific peptidase 35" Q9P2H5 11 78188812-78215232 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 9 "Early spermatids: 39.1;Granulosa cells: 30.8;Late spermatids: 121.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA055213, HPA058592" Uncertain Approved "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 31: Spermatids - Spermatogenesis" "Nucleoli fibrillar center" Nucleoplasm "HPA055213: AB_2682740, HPA058592: AB_2683766" "unprognostic (6.69e-2)" "unprognostic (1.17e-2)" "unprognostic (1.69e-1)" "unprognostic (6.87e-3)" "unprognostic (3.38e-2)" "unprognostic (1.08e-2)" "unprognostic (2.00e-1)" "unprognostic (1.46e-1)" "unprognostic (3.57e-2)" "unprognostic (3.84e-3)" "unprognostic (1.03e-2)" "unprognostic (3.11e-2)" "unprognostic (1.29e-3)" "unprognostic (2.93e-1)" "unprognostic (1.31e-1)" "unprognostic (4.38e-2)" "unprognostic (1.49e-2)" 6.1 19.8 8.0 3.6 7.4 2.5 5.1 5.1 8.0 9.2 7.4 7.6 3.5 6.7 3.2 6.0 6.4 3.5 10.2 8.3 7.1 6.2 16.8 7.0 3.3 9.0 8.2 7.4 5.9 12.4 13.4 4.7 9.4 5.9 1.9 2.1 3.9 3.2 4.1 3.0 4.5 4.7 3.9 4.9 4.6 4.5 8.3 6.2 8.7 4.0 2.6 6.6 7.7 6.4 2.2 3.3 5.7 6.1 9.7 8.7 3.9 5.0 5.8 5.8 4.0 8.4 4.7 1.7 5.0 9.5 6.2 5.8 3.8 7.8 3.4 12.8 2.0 2.9 9.8 5.0 7.4 1.8 8.3 7.4 5.1 12.1 3.5 11.4 7.2 6.5 4.1 4.2 4.6 2.0 4.7 7.6 1.7 6.2 5.3 2.9 5.2 2.0 4.5 4.1 2.8 5.9 3.9 5.1 1.9 8.1 4.3 1.6 8.9 10.6 5.9 12.8 2.7 5.7 2.0 2.7 3.1 2.0 6.3 0.0 0.0 0.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.0 7.4 5.1 8.0 8.3 7.1 9.0 8.2 9.4 3.9 8.3 6.4 1.3 0.0 1.8 5.9 1.2 0.8 0.2 0.7 3.4 0.8 1.0 0.6 3.5 0.0 0.3 0.0 6.2 0.7 1.0 1.2 0.0 1.1 39.1 1.3 2.7 1.9 0.0 0.4 5.2 2.0 1.6 2.0 5.1 1.2 0.0 30.8 1.4 2.7 1.6 0.0 4.8 0.9 0.0 0.6 0.8 121.6 1.5 1.4 1.8 2.8 2.7 0.4 0.0 3.5 2.8 2.0 0.1 3.0 0.8 0.3 0.8 1.0 0.5 0.6 6.6 0.7 1.3 1.2 2.4 4.1 1.0 0.3 2.9 2.1 1.3 0.2 USP36 "FLJ12851, KIAA1453" ENSG00000055483 "Ubiquitin specific peptidase 36" Q9P275 17 78787381-78841441 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012082, HPA012395, HPA052860" Uncertain Supported Enhanced "Nucleoli,Nucleoli rim,Nuclear speckles" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 50: Non-specific - Ribosome" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 24: Non-specific - Transcription regulation" "Nucleoli, Nucleoli rim" "Nuclear speckles" "HPA012082: AB_1858682, HPA012395: , HPA052860: AB_2681974" "unprognostic (1.94e-2)" "unprognostic (2.80e-2)" "unprognostic (1.07e-1)" "prognostic unfavorable (5.18e-5)" "unprognostic (9.35e-2)" "unprognostic (1.98e-1)" "unprognostic (2.50e-3)" "unprognostic (1.35e-1)" "unprognostic (2.04e-1)" "unprognostic (1.33e-1)" "unprognostic (1.68e-2)" "unprognostic (2.78e-2)" "unprognostic (1.31e-2)" "unprognostic (1.45e-1)" "unprognostic (1.81e-1)" "unprognostic (4.03e-3)" "unprognostic (1.78e-1)" 43.9 37.9 20.0 21.5 21.9 46.6 32.9 29.3 23.9 32.6 27.5 31.2 13.4 26.8 22.9 25.0 34.2 18.7 30.2 21.4 20.6 34.4 30.3 36.1 20.6 22.6 21.3 67.4 44.5 18.1 50.3 26.0 21.5 36.2 15.8 26.3 24.9 13.1 30.3 40.4 26.6 16.3 19.4 30.7 31.2 22.2 21.2 15.1 31.6 11.7 20.5 29.3 29.8 30.1 42.7 50.3 14.6 26.9 30.5 33.7 27.8 34.1 34.5 32.1 21.5 49.2 21.0 54.0 16.9 30.6 34.8 30.6 34.5 25.4 57.0 13.0 52.1 49.4 81.0 51.9 31.3 54.7 26.0 29.5 41.0 45.8 101.6 24.7 28.3 24.1 40.0 55.3 26.8 32.6 50.1 55.1 22.6 31.6 39.9 38.1 31.8 36.3 20.2 44.1 42.8 25.8 24.5 112.5 63.7 31.3 29.2 34.4 24.3 75.2 35.3 44.3 61.1 40.7 17.4 66.1 29.6 41.9 24.0 10.1 3.0 2.4 5.5 4.2 6.5 5.1 5.2 4.8 1.8 4.7 5.7 5.6 4.3 4.5 2.7 9.7 3.8 1.9 20.0 21.9 29.3 23.9 21.4 20.6 22.6 21.3 21.5 19.4 21.2 30.1 27.4 12.8 37.4 23.5 55.9 51.7 28.4 8.2 40.9 33.2 18.1 16.9 14.1 18.6 18.8 14.7 33.3 8.3 66.3 14.4 5.9 10.2 20.7 22.3 24.0 28.4 18.5 14.7 19.0 9.6 11.3 26.6 25.0 42.7 20.3 12.8 12.1 16.5 43.3 26.9 22.5 18.6 10.2 24.5 72.8 8.5 11.8 49.4 30.2 10.3 14.9 13.2 16.5 13.6 19.8 13.2 8.4 12.4 57.1 32.4 7.3 5.0 11.1 32.1 6.6 22.1 23.1 18.4 16.5 24.4 43.3 12.9 73.6 13.1 18.6 22.2 USP37 KIAA1594 ENSG00000135913 "Ubiquitin specific peptidase 37" Q86T82 2 218450251-218568351 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 119.4;Late spermatids: 145.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045160 Approved Approved Nucleoplasm,Nucleoli NA Yes "Cluster 44: Non-specific - Transcription" "Cluster 6: Brain - Smell perception" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Nucleoli" "HPA045160: AB_10795620" "unprognostic (7.00e-2)" "unprognostic (2.29e-1)" "unprognostic (8.83e-2)" "unprognostic (9.19e-4)" "unprognostic (1.83e-1)" "prognostic favorable (2.85e-4)" "unprognostic (2.18e-2)" "unprognostic (1.14e-1)" "unprognostic (9.66e-3)" "unprognostic (1.17e-1)" "unprognostic (3.78e-3)" "unprognostic (1.11e-1)" "unprognostic (3.82e-2)" "unprognostic (3.26e-1)" "unprognostic (2.87e-1)" "unprognostic (6.69e-2)" "unprognostic (6.41e-3)" 2.7 4.1 3.5 4.4 4.7 11.8 4.7 8.5 4.9 3.6 1.9 3.0 2.9 4.2 7.5 3.9 3.3 3.5 2.3 3.3 4.0 2.9 3.8 3.0 6.0 3.8 4.0 5.9 3.0 4.0 1.4 4.0 4.0 3.6 3.5 9.1 3.9 3.0 2.9 3.9 3.3 3.2 2.5 3.8 3.4 12.7 3.4 6.3 5.0 4.2 4.9 3.6 2.2 8.3 9.6 6.9 14.2 11.0 3.6 4.4 12.1 7.1 5.1 12.2 13.6 13.1 7.4 8.7 7.5 5.6 9.3 8.9 15.7 8.0 13.4 12.0 8.3 23.5 13.6 8.7 4.1 15.6 11.3 2.4 4.7 12.9 9.2 4.5 5.3 15.0 17.3 16.2 7.8 7.2 20.1 10.6 12.2 6.2 5.9 16.0 21.3 8.0 4.2 11.2 15.5 8.4 11.5 5.6 7.2 13.6 6.4 10.8 6.8 13.7 12.0 7.7 9.5 11.0 10.4 17.6 7.4 11.2 9.5 4.2 2.0 3.8 3.1 2.3 3.2 2.5 2.6 2.7 2.1 3.2 4.0 2.6 1.6 3.2 2.2 2.9 3.6 1.2 3.5 4.7 8.5 4.9 3.3 4.0 3.8 4.0 4.0 2.5 3.4 8.3 12.8 0.0 11.0 34.3 16.5 19.5 7.0 7.1 22.2 14.7 14.4 10.2 4.9 4.3 9.6 7.3 27.1 8.4 13.4 5.5 0.0 5.8 119.4 13.3 11.8 14.2 10.3 16.6 47.4 2.3 6.6 13.2 9.2 16.4 5.1 16.2 12.5 11.0 7.8 15.2 40.0 8.9 4.1 8.5 22.9 145.5 9.9 17.2 21.4 27.2 10.2 9.1 10.3 35.2 60.5 4.9 7.4 9.8 14.6 12.1 7.1 4.2 11.1 19.9 6.6 12.7 21.6 60.8 31.4 13.6 20.6 7.3 19.7 10.9 7.6 7.1 USP38 "HP43.8KD, KIAA1891" ENSG00000170185 "Ubiquitin specific peptidase 38" Q8NB14 4 143184917-143223874 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 36.6" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-266/84: 65.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036990, HPA047948" Uncertain Approved Nucleoplasm,Centrosome,Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 16: U-266 - Nucleosome" "Cluster 44: Endometrium - Transcription" Nucleoplasm "Centrosome, Cytosol" "HPA036990: AB_2675419, HPA047948: AB_2680220" "unprognostic (5.01e-2)" "unprognostic (2.45e-1)" "unprognostic (2.04e-3)" "unprognostic (2.99e-2)" "unprognostic (1.87e-1)" "unprognostic (2.61e-2)" "unprognostic (1.67e-1)" "unprognostic (7.49e-2)" "unprognostic (3.66e-2)" "unprognostic (3.97e-2)" "unprognostic (8.03e-2)" "unprognostic (7.72e-3)" "prognostic favorable (1.20e-4)" "unprognostic (3.15e-1)" "unprognostic (1.26e-1)" "unprognostic (1.29e-1)" "unprognostic (1.02e-1)" 6.5 4.4 2.5 6.2 4.3 21.6 4.6 4.3 2.9 6.2 4.3 8.0 7.9 5.5 2.3 7.0 4.3 5.2 6.8 2.2 2.4 7.0 13.2 6.3 6.4 5.9 3.8 3.7 8.2 7.7 3.3 8.1 4.9 5.5 5.7 4.5 5.8 5.6 36.6 5.9 7.2 5.7 4.9 7.4 6.3 6.8 3.2 9.3 7.4 21.3 5.8 6.8 3.9 6.8 8.5 7.9 6.6 11.3 8.4 8.2 5.1 13.0 12.5 11.8 10.1 23.1 11.7 10.5 9.2 11.5 7.8 6.5 15.9 13.5 10.2 26.0 10.5 9.7 8.5 4.7 11.3 19.4 9.4 10.2 11.1 12.0 9.5 8.3 12.2 11.9 21.5 31.5 7.9 13.3 25.6 3.7 6.1 17.7 15.3 16.7 10.2 10.1 7.2 9.2 13.8 12.3 10.5 17.3 10.9 4.9 10.8 7.6 14.6 10.8 9.1 9.6 14.1 35.7 65.3 18.6 10.9 14.4 9.3 13.4 4.5 9.7 5.7 4.6 7.0 4.6 4.9 4.9 6.6 4.5 4.8 4.2 4.3 10.1 4.9 2.7 7.9 4.3 2.5 4.3 4.3 2.9 2.2 2.4 5.9 3.8 4.9 4.9 3.2 6.8 21.5 22.4 19.8 13.7 19.5 53.5 21.0 6.2 25.6 7.4 20.8 13.7 18.4 10.0 12.2 0.0 12.5 12.8 22.2 35.5 1.9 8.3 36.4 20.7 26.1 15.3 30.6 31.5 19.6 7.7 7.1 13.4 26.0 52.1 3.8 9.9 17.9 38.4 10.6 8.4 15.9 20.2 4.1 17.0 16.6 20.3 6.8 21.9 12.4 9.4 10.1 15.1 12.3 18.6 22.8 10.2 13.4 9.4 38.6 16.8 17.0 18.5 10.9 8.9 13.1 15.0 14.1 11.3 4.7 31.5 59.1 26.7 23.2 11.0 17.6 45.4 USP4 "UNP, Unph" ENSG00000114316 "Ubiquitin specific peptidase 4" Q13107 3 49277144-49340712 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 131.8;Late spermatids: 104.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA018499 Approved Approved "Plasma membrane,Cytosol" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 30: Epithelial cell lines - Translation" "Cluster 34: Spermatids - Unknown function" "Plasma membrane, Cytosol" "HPA018499: AB_1858689" "unprognostic (2.34e-3)" "unprognostic (1.52e-1)" "unprognostic (2.22e-3)" "unprognostic (6.12e-2)" "unprognostic (3.51e-1)" "unprognostic (4.33e-2)" "unprognostic (9.42e-2)" "prognostic favorable (4.46e-5)" "unprognostic (3.54e-1)" "unprognostic (9.07e-3)" "unprognostic (2.78e-2)" "unprognostic (1.70e-3)" "prognostic favorable (4.29e-5)" "unprognostic (7.30e-2)" "unprognostic (1.00e-1)" "unprognostic (1.18e-2)" "unprognostic (1.65e-2)" 25.2 20.3 24.2 26.5 26.3 53.7 24.9 24.5 28.2 27.7 27.1 25.4 18.3 24.4 21.6 26.0 22.4 18.3 26.5 23.7 23.4 21.8 20.2 29.5 30.9 23.9 24.4 24.5 19.0 24.1 16.4 23.3 23.9 23.7 23.4 26.9 21.0 21.7 31.6 31.4 22.5 24.0 22.4 33.7 20.2 28.0 24.8 37.0 23.0 28.8 33.7 25.8 25.0 24.5 14.2 15.8 21.6 28.8 38.7 40.1 14.7 36.4 32.9 46.7 41.3 16.8 34.8 27.1 14.4 53.9 27.4 18.9 28.6 52.6 42.5 42.1 8.4 60.3 31.9 19.6 57.0 32.5 34.0 42.8 23.3 51.0 41.5 34.3 55.0 29.9 21.6 41.6 42.1 24.5 38.3 55.8 18.7 17.7 26.9 15.6 13.3 23.9 37.5 29.2 17.5 24.0 27.2 19.3 14.0 21.6 13.5 51.2 50.1 31.1 17.2 39.6 22.5 33.6 17.3 38.6 28.6 50.1 36.5 70.1 83.6 94.8 48.1 69.2 53.7 51.0 50.2 48.9 74.6 41.4 47.7 42.2 179.2 72.4 81.2 28.4 59.7 78.0 24.2 26.3 24.5 28.2 23.7 23.4 23.9 24.4 23.9 22.4 24.8 24.5 24.3 41.7 25.1 28.1 24.7 18.7 17.9 17.2 22.2 17.5 10.9 10.3 17.9 10.0 23.2 20.2 20.9 22.7 27.9 13.6 21.5 16.5 131.8 17.3 18.3 22.1 10.7 31.6 30.8 13.6 14.3 17.9 27.5 21.1 33.6 21.4 17.5 14.6 24.0 11.8 26.4 13.8 16.2 38.6 21.0 104.9 15.5 34.2 16.0 16.9 36.0 13.9 23.7 25.6 20.2 18.9 7.6 19.2 29.2 17.6 14.5 13.4 28.6 20.5 13.1 18.4 17.0 35.3 14.5 17.9 18.5 24.2 29.4 17.0 13.9 14.5 USP40 FLJ10785 ENSG00000085982 "Ubiquitin specific peptidase 40" Q9NVE5 2 233475520-233566782 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 79.3;Oligodendrocytes: 127.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005821 Uncertain Approved "Vesicles,Focal adhesion sites" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 68: Epididymis - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 64: Astrocytes - Nervous system maintenance" Vesicles "Focal adhesion sites" "HPA005821: AB_1080526" "unprognostic (2.19e-1)" "unprognostic (1.04e-1)" "unprognostic (1.13e-1)" "unprognostic (1.33e-1)" "unprognostic (3.70e-1)" "unprognostic (2.15e-1)" "unprognostic (5.30e-2)" "unprognostic (2.25e-1)" "unprognostic (1.80e-2)" "unprognostic (1.18e-1)" "unprognostic (1.96e-1)" "unprognostic (1.26e-1)" "unprognostic (2.22e-1)" "unprognostic (1.45e-1)" "unprognostic (4.09e-2)" "unprognostic (1.90e-2)" "unprognostic (2.53e-2)" 11.8 12.0 10.4 7.5 17.0 3.4 13.9 12.8 11.4 10.0 16.5 9.4 10.5 10.6 24.0 10.4 11.5 11.6 8.2 10.2 12.0 14.2 13.2 12.5 7.2 19.4 14.2 15.9 14.0 16.8 8.5 12.4 19.0 13.5 9.5 14.2 12.9 10.4 9.6 19.7 10.1 8.5 12.3 9.9 13.1 14.7 16.2 10.1 16.4 7.6 7.8 9.6 7.5 25.4 17.3 19.9 17.6 12.0 25.2 23.0 15.7 16.4 12.4 14.7 16.0 14.3 20.2 0.4 4.7 26.4 38.6 30.3 13.3 29.7 20.6 0.0 9.0 13.3 17.4 24.3 22.3 5.8 8.9 22.2 21.1 22.2 30.9 26.2 17.3 8.1 22.0 3.2 21.4 14.0 6.2 8.5 7.9 17.8 16.0 0.0 36.3 8.1 17.9 27.6 9.6 10.3 13.5 13.5 16.9 12.9 15.4 12.9 17.3 20.9 13.1 8.9 20.6 6.0 4.9 0.8 27.1 10.2 18.6 0.0 1.0 0.0 0.5 1.1 0.2 0.4 0.5 0.4 1.5 0.7 0.7 0.7 0.1 0.5 0.9 1.9 0.8 0.5 10.4 17.0 12.8 11.4 10.2 12.0 19.4 14.2 19.0 12.3 16.2 25.4 11.8 32.1 35.5 79.3 7.9 7.4 9.1 13.6 15.4 18.1 17.0 14.7 10.7 10.0 19.9 16.5 25.0 21.2 6.7 9.9 7.9 9.4 8.4 19.8 18.3 11.1 15.0 5.7 25.9 12.6 10.6 11.9 21.4 21.3 9.5 23.4 12.8 25.4 8.2 23.5 38.2 10.9 4.1 11.6 3.6 10.7 6.8 9.1 3.6 40.3 5.9 11.9 4.1 48.2 127.7 10.5 12.6 8.2 10.9 12.9 13.9 14.6 21.0 19.4 13.1 17.5 10.6 30.2 20.9 17.2 10.5 15.7 5.5 21.1 12.1 10.0 USP41 ENSG00000161133 "Ubiquitin specific peptidase 41" 22 20350578-20377251 "Metabolic proteins, Predicted intracellular proteins" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "RH-30: 1.2;SCLC-21H: 1.5" NA NA "Cluster 7: SCLC-21H - Neuronal signaling" "unprognostic (4.01e-6)" "unprognostic (1.26e-1)" "unprognostic (1.44e-1)" "unprognostic (4.63e-3)" "unprognostic (7.44e-2)" "unprognostic (1.75e-1)" "unprognostic (5.28e-2)" "unprognostic (4.34e-2)" "unprognostic (3.66e-2)" "unprognostic (9.91e-5)" "unprognostic (3.43e-2)" "unprognostic (3.51e-2)" "unprognostic (2.54e-2)" "unprognostic (4.98e-2)" "unprognostic (1.40e-1)" "unprognostic (4.63e-1)" 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.2 0.2 0.0 0.4 0.0 0.1 0.0 1.2 0.0 0.0 0.5 1.5 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP42 FLJ12697 ENSG00000106346 "Ubiquitin specific peptidase 42" Q9H9J4 7 6104884-6161564 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Differentiation, Spermatogenesis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 89.1;Spermatocytes: 72.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006939, HPA064800" Approved Nucleoplasm,Nucleoli NA NA "Cluster 10: Basophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 59: Non-specific - Transcription" Nucleoplasm Nucleoli "HPA006939: , HPA064800: AB_2685355" "unprognostic (1.48e-2)" "unprognostic (1.47e-1)" "unprognostic (2.59e-1)" "unprognostic (1.69e-1)" "unprognostic (1.30e-2)" "unprognostic (1.53e-1)" "unprognostic (1.19e-2)" "unprognostic (3.32e-1)" "unprognostic (1.05e-1)" "unprognostic (2.82e-1)" "unprognostic (6.21e-3)" "unprognostic (2.47e-2)" "unprognostic (3.17e-3)" "unprognostic (3.14e-2)" "unprognostic (3.06e-2)" "unprognostic (2.19e-2)" "unprognostic (2.66e-1)" 3.8 3.0 3.1 3.2 3.0 13.4 3.9 5.8 4.4 4.3 2.4 4.5 4.5 4.9 3.6 3.7 4.3 3.4 3.2 3.0 3.0 3.9 4.0 4.1 3.8 2.8 3.1 4.9 3.8 4.7 3.8 3.3 2.7 3.8 3.4 5.8 3.5 3.1 4.3 5.4 4.3 4.1 2.9 4.4 3.6 15.2 3.2 5.7 4.0 3.4 3.2 4.0 3.8 3.2 10.2 7.4 13.1 12.9 7.4 5.5 9.0 5.4 6.9 6.2 6.1 5.3 5.2 12.0 3.4 6.7 9.2 9.3 11.1 5.9 6.7 2.9 8.6 5.6 6.1 5.5 6.3 13.0 6.1 6.4 6.8 6.7 8.5 5.7 7.7 10.0 21.7 7.9 4.1 9.1 7.9 14.6 14.8 5.2 5.6 14.9 10.2 8.2 5.9 5.3 10.0 17.7 6.9 14.0 4.3 12.0 6.5 6.6 6.5 5.5 20.5 7.0 6.5 7.0 6.3 10.3 4.6 7.8 11.0 0.6 0.3 0.9 0.5 0.6 0.7 0.4 0.6 0.3 0.3 0.2 0.4 1.0 0.3 0.5 0.3 0.6 0.5 0.2 3.1 3.0 5.8 4.4 3.0 3.0 2.8 3.1 2.7 2.9 3.2 3.2 13.7 12.8 7.0 19.6 16.1 40.5 18.2 5.2 26.7 18.7 17.4 10.8 10.5 8.6 6.8 1.8 22.9 8.3 16.4 20.7 0.0 10.4 89.1 27.1 15.3 14.4 10.7 10.8 26.1 10.4 8.4 13.4 15.3 25.6 9.5 13.4 12.8 9.8 8.2 21.9 26.2 18.1 8.2 9.1 19.9 42.5 14.3 12.4 10.6 18.7 7.7 10.1 12.3 18.6 26.2 12.0 7.7 12.8 21.7 22.3 12.4 5.7 10.6 18.7 13.1 16.2 14.9 72.4 37.0 23.1 41.5 26.8 19.2 6.4 14.4 15.3 USP43 FLJ30626 ENSG00000154914 "Ubiquitin specific peptidase 43" Q70EL4 17 9644698-9729687 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 37.9;Excitatory neurons: 35.5;Glandular and luminal cells: 52.5;Oligodendrocyte precursor cells: 73.4;Syncytiotrophoblasts: 73.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 11.7;SK-BR-3: 8.1;T-47d: 9.9" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" "HPA023389, HPA027762, HPA027763" Uncertain Approved "Nucleoplasm,Nuclear speckles" NA NA "Cluster 29: Non-specific - Vesicular transport" "Cluster 28: BEWO - Transcription regulation" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Nuclear speckles" "HPA023389: AB_1858691, HPA027762: AB_10603001, HPA027763: " "unprognostic (1.39e-1)" "unprognostic (1.75e-2)" "unprognostic (1.07e-1)" "unprognostic (2.30e-3)" "unprognostic (1.08e-1)" "unprognostic (5.24e-2)" "unprognostic (2.04e-1)" "unprognostic (6.40e-3)" "unprognostic (2.26e-1)" "unprognostic (3.05e-3)" "unprognostic (2.41e-2)" "unprognostic (7.49e-2)" "unprognostic (5.95e-2)" "prognostic favorable (5.39e-4)" "unprognostic (3.24e-1)" "unprognostic (2.06e-1)" "unprognostic (3.28e-1)" 0.3 0.2 2.6 0.6 3.4 0.7 1.9 0.8 4.1 2.9 2.9 3.5 4.2 1.9 1.0 6.5 4.2 1.2 0.0 3.3 1.4 4.0 9.1 3.2 0.1 2.5 4.6 0.1 5.0 1.1 3.5 8.3 2.5 9.8 3.2 1.4 4.3 2.2 0.0 2.2 3.5 0.2 2.1 0.3 2.1 3.2 2.3 0.3 1.7 0.0 0.7 1.1 2.4 2.5 5.6 1.4 0.0 0.5 0.0 0.0 11.7 0.1 0.2 0.6 1.6 2.8 4.5 0.0 1.8 0.2 2.5 6.8 0.6 5.3 0.6 3.6 1.8 0.3 3.0 1.0 0.1 0.5 0.0 0.0 6.8 0.3 2.8 0.3 0.0 0.8 0.0 0.0 0.0 2.6 0.9 4.6 0.7 4.8 0.3 3.6 0.0 0.8 4.1 3.0 0.7 0.0 2.4 8.1 1.0 3.7 9.9 1.4 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.7 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.6 3.4 0.8 4.1 3.3 1.4 2.5 4.6 2.5 2.1 2.3 2.5 0.0 3.2 3.1 1.6 0.3 4.7 7.8 4.6 5.2 0.5 7.0 2.4 0.6 4.3 7.4 11.0 6.2 26.2 0.6 14.3 1.9 4.4 1.1 37.9 4.2 0.5 2.4 3.2 35.5 4.7 23.7 0.8 7.7 52.5 0.0 0.9 0.4 15.6 2.7 0.0 4.0 8.3 2.0 0.9 0.3 1.1 0.0 0.6 5.4 0.0 0.3 8.4 0.0 73.4 1.2 11.3 3.5 0.0 0.2 10.6 8.7 1.8 30.2 1.5 0.0 0.0 1.0 1.5 0.3 12.3 3.3 73.2 0.7 0.0 9.7 11.8 USP44 FLJ14528 ENSG00000136014 "Ubiquitin specific peptidase 44" Q9H0E7 12 95516560-95551476 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 7.1;testis: 24.2" "Cell type enriched" "Detected in many" 4 "Early spermatids: 482.2" "Cancer enhanced" "Detected in some" "testis cancer: 3.0" "Region enriched" "Detected in many" 6 "cerebellum: 7.1" "Immune cell enhanced" "Detected in many" "naive CD4 T-cell: 6.1" "Group enriched" "Detected in many" 41 "B-cells: 4.6;T-cells: 6.1" "Cell line enhanced" "Detected in some" "HEL: 26.4;JURKAT: 58.4;NTERA-2: 138.3" "Not detected" "Not detected" "Low region specificity" "Detected in single" HPA026543 Approved "Nucleoli fibrillar center,Microtubules" NA NA "Cluster 30: Non-specific - Translation" "Cluster 78: Testis - Spermatogenesis" "Cluster 5: NTERA-2 - Transcription" "Cluster 23: Spermatids - Flagellum & Golgi organization" "Nucleoli fibrillar center, Microtubules" "HPA026543: AB_1858692" "unprognostic (2.12e-2)" "unprognostic (1.14e-1)" "unprognostic (4.68e-2)" "unprognostic (1.01e-3)" "unprognostic (1.83e-4)" "unprognostic (7.18e-4)" "unprognostic (5.55e-2)" "unprognostic (1.85e-2)" "unprognostic (2.16e-1)" "unprognostic (3.73e-2)" "unprognostic (6.88e-2)" "unprognostic (2.97e-2)" "unprognostic (8.12e-2)" "unprognostic (1.41e-2)" "unprognostic (1.08e-1)" "unprognostic (7.41e-2)" "unprognostic (7.07e-2)" 0.7 0.6 0.6 1.0 0.8 0.3 0.9 7.1 1.0 0.9 0.0 1.2 0.3 1.3 0.7 0.4 1.2 0.8 0.5 0.6 0.5 1.4 0.1 3.9 1.1 0.8 0.9 0.9 2.3 1.7 1.3 0.1 1.0 0.7 0.4 1.7 1.1 1.6 0.2 0.3 0.8 0.9 0.7 1.5 0.6 24.2 0.5 3.6 1.3 0.3 1.2 0.5 0.5 1.2 0.2 0.4 11.4 0.0 0.1 0.1 0.4 1.1 3.3 1.4 0.5 0.0 0.1 0.1 3.4 0.0 0.0 0.1 0.0 0.0 1.9 0.0 5.8 26.4 0.0 0.0 5.8 10.8 0.5 0.1 0.0 0.8 0.0 0.6 0.6 58.4 4.3 0.0 0.0 0.0 13.9 0.1 138.3 0.0 0.0 0.0 0.0 0.0 2.4 0.8 8.8 5.9 0.0 0.0 0.1 13.2 0.1 0.9 0.0 0.1 0.0 0.0 0.0 0.0 0.3 4.6 0.0 1.0 0.3 0.0 0.0 0.0 1.1 0.0 2.4 4.6 1.7 1.5 0.0 3.7 6.1 4.0 0.1 0.1 0.0 0.0 0.2 1.0 0.6 0.8 7.1 1.0 0.6 0.5 0.8 0.9 1.0 0.7 0.5 1.2 1.9 12.8 31.0 1.3 5.7 1.0 3.4 0.3 4.6 8.6 1.5 3.2 1.8 0.0 3.8 7.3 6.2 2.8 0.6 0.1 0.0 4.4 482.2 0.9 2.2 2.5 0.0 0.4 5.1 3.1 0.5 3.5 1.1 1.8 0.0 10.6 1.8 0.0 0.1 0.0 16.2 0.0 0.0 0.3 1.0 116.6 5.6 0.8 3.6 1.9 0.6 2.4 1.0 15.6 4.0 0.9 0.1 3.4 1.1 5.0 0.1 1.0 0.3 9.5 6.6 2.9 3.7 77.6 6.7 0.6 0.9 1.1 3.2 2.5 0.1 1.9 USP45 MGC14793 ENSG00000123552 "Ubiquitin specific peptidase 45" Q70EL2 6 99432325-99521728 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease variant, Leber congenital amaurosis" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 7 "brain: 53.5" "Cell type enhanced" "Detected in many" "Excitatory neurons: 47.1;Inhibitory neurons: 44.4;Oligodendrocytes: 39.4" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in all" 6 "cerebellum: 53.5" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029602, HPA029604" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 1: K-562 - Erythropoiesis" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoplasm, Cytosol" "HPA029602: AB_10600418, HPA029604: AB_10602283" "unprognostic (7.81e-3)" "unprognostic (3.10e-3)" "unprognostic (1.63e-2)" "unprognostic (6.62e-2)" "unprognostic (1.02e-2)" "unprognostic (1.92e-1)" "unprognostic (2.15e-2)" "unprognostic (1.01e-1)" "unprognostic (2.77e-2)" "unprognostic (8.65e-2)" "unprognostic (2.95e-3)" "unprognostic (1.10e-1)" "unprognostic (3.43e-3)" "unprognostic (1.13e-1)" "unprognostic (3.53e-1)" "unprognostic (1.43e-1)" "unprognostic (6.91e-2)" 6.1 4.4 5.2 4.9 5.8 4.4 4.6 53.5 9.4 4.3 3.8 5.3 7.3 5.1 4.8 5.3 4.0 6.2 6.2 5.8 6.3 6.3 4.2 3.7 7.4 6.0 7.7 4.5 4.0 4.5 3.6 5.2 8.2 5.1 6.7 6.7 4.0 4.2 6.0 6.3 5.8 4.5 5.3 4.6 4.4 3.3 6.2 3.1 5.3 5.5 5.2 4.3 3.8 9.0 5.9 4.0 8.1 11.2 14.3 13.5 8.7 10.3 11.1 10.1 14.7 8.2 6.4 15.2 7.3 10.3 11.9 7.7 12.1 9.8 13.9 12.2 12.0 15.2 8.4 6.7 11.4 14.2 8.3 15.3 7.6 9.2 15.5 10.7 15.4 13.8 37.2 14.8 9.6 5.5 4.5 13.3 12.8 9.1 8.9 6.8 5.9 8.9 13.8 6.8 11.3 9.2 7.0 9.1 7.8 10.0 4.9 6.8 15.5 5.5 7.1 8.1 15.5 6.3 6.2 29.1 9.8 13.1 10.1 2.9 1.4 0.4 3.2 0.8 4.2 5.3 2.7 4.0 2.4 6.7 1.9 1.9 0.3 1.9 2.0 3.6 2.6 1.0 5.2 5.8 53.5 9.4 5.8 6.3 6.0 7.7 8.2 5.3 6.2 9.0 13.3 3.2 5.8 22.5 13.3 2.3 9.6 6.8 4.6 10.3 4.4 4.6 9.4 4.3 4.7 3.7 18.8 6.4 7.3 5.9 5.9 4.3 15.7 10.1 10.3 7.6 2.4 4.2 47.1 2.5 6.6 7.1 9.7 4.3 2.5 5.8 6.8 4.5 4.0 10.1 44.4 2.9 10.2 4.8 2.6 10.2 13.1 4.6 3.6 22.5 10.0 5.4 2.1 32.6 39.4 5.0 3.1 8.6 6.5 8.6 8.3 15.8 10.4 7.4 0.0 6.3 6.7 1.9 7.5 5.2 2.8 7.4 7.1 5.8 7.3 6.9 USP46 FLJ12552 ENSG00000109189 "Ubiquitin specific peptidase 46" P62068 4 52590960-52659301 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Behavior, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 4 "Bipolar cells: 150.8;Early spermatids: 229.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007288, CAB076369, CAB076370" Uncertain Approved "Nucleoli,Nucleoli rim" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 39: Non-specific - Mitochondria" "Cluster 12: NES - Nervous system development" "Cluster 29: Early spermatids - Spermatogenesis" "Nucleoli, Nucleoli rim" "CAB076369: AB_2665642, CAB076370: AB_2665643, HPA007288: AB_1080531" "unprognostic (1.15e-2)" "unprognostic (1.64e-1)" "unprognostic (1.19e-1)" "unprognostic (1.61e-2)" "unprognostic (1.31e-1)" "unprognostic (1.41e-1)" "unprognostic (1.53e-3)" "unprognostic (1.59e-1)" "unprognostic (2.45e-2)" "unprognostic (1.80e-2)" "unprognostic (2.89e-1)" "unprognostic (1.95e-1)" "unprognostic (1.05e-1)" "unprognostic (1.45e-1)" "unprognostic (3.95e-2)" "unprognostic (2.02e-2)" "unprognostic (1.28e-1)" 4.4 8.6 30.4 3.3 31.2 2.9 6.4 27.4 31.5 7.6 22.4 3.9 4.4 6.5 5.4 11.5 7.0 5.3 28.6 30.8 33.3 9.9 2.9 3.9 3.7 27.9 33.9 11.0 5.2 10.4 4.6 5.3 26.7 6.9 4.0 11.5 8.3 6.7 14.5 7.5 4.2 5.0 30.4 3.3 6.0 12.3 32.5 3.4 9.3 12.5 5.5 6.0 7.4 26.8 8.1 5.7 18.0 13.3 19.1 23.8 19.8 13.0 10.5 9.5 7.9 11.5 6.2 5.4 14.9 13.0 13.4 4.7 31.6 15.1 17.2 4.7 11.1 8.4 5.3 12.8 19.1 11.2 9.4 20.4 13.9 9.7 9.1 18.4 14.2 7.4 8.3 7.4 20.3 7.4 4.8 5.9 13.3 9.0 6.8 12.0 13.1 1.1 20.3 14.8 10.8 12.9 6.4 21.5 12.9 17.1 7.9 8.2 13.3 9.2 20.1 10.9 19.9 7.5 3.7 4.2 14.2 6.7 11.6 0.7 0.4 0.1 0.7 0.4 0.5 0.4 1.2 0.6 0.9 0.4 0.2 0.2 0.1 0.4 0.3 1.4 0.4 0.3 30.4 31.2 27.4 31.5 30.8 33.3 27.9 33.9 26.7 30.4 32.5 26.8 10.0 6.4 7.2 24.2 6.4 5.4 11.2 15.2 26.2 150.8 13.7 11.7 44.9 14.3 16.4 14.7 4.2 12.1 10.7 5.2 21.5 10.8 229.8 18.4 34.9 12.5 4.2 6.7 32.6 12.0 12.5 17.8 17.3 15.6 0.0 22.9 13.6 6.8 5.8 35.3 24.3 5.9 10.2 8.4 4.6 34.1 28.9 7.9 8.8 21.5 12.9 30.0 5.2 30.2 12.6 12.5 9.9 36.1 9.5 21.1 3.9 17.1 23.8 8.7 6.6 16.2 15.9 3.2 14.4 25.9 8.2 7.7 8.0 18.3 7.1 17.7 USP47 ENSG00000170242 "Ubiquitin specific peptidase 47" Q96K76 11 11841423-11961887 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 315.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029286, HPA029289" Supported Approved "Vesicles,Intermediate filaments" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 54: Cardiomyocytes - Muscle contraction" "Intermediate filaments" Vesicles "HPA029286: AB_10599852, HPA029289: AB_10601675" "unprognostic (2.02e-1)" "unprognostic (2.72e-1)" "unprognostic (3.05e-1)" "unprognostic (1.84e-1)" "unprognostic (2.99e-2)" "unprognostic (2.65e-2)" "unprognostic (2.27e-2)" "unprognostic (7.39e-2)" "unprognostic (1.54e-2)" "unprognostic (7.05e-2)" "unprognostic (2.83e-2)" "unprognostic (2.35e-1)" "unprognostic (1.51e-1)" "unprognostic (9.96e-3)" "unprognostic (1.90e-1)" "unprognostic (1.49e-1)" "unprognostic (2.85e-1)" 15.7 14.3 11.9 11.4 15.8 19.0 15.1 17.3 12.8 14.3 10.2 19.8 10.3 17.2 15.6 16.1 13.5 12.3 23.5 12.5 14.1 13.2 23.3 16.2 13.3 14.1 12.8 15.9 16.9 22.2 13.8 16.7 15.0 16.6 12.3 25.7 14.1 15.4 59.8 18.0 14.1 17.8 14.1 11.8 16.6 15.0 12.7 19.1 14.9 33.6 13.8 16.7 14.2 20.6 26.8 15.7 30.3 13.1 21.8 23.2 12.6 31.6 22.3 20.1 22.1 16.5 22.2 29.6 13.3 28.0 23.7 17.8 23.7 15.3 30.3 27.5 20.4 18.6 30.3 12.6 21.5 25.0 23.9 22.3 22.5 12.3 29.0 26.1 21.8 21.7 35.8 23.7 25.4 10.6 21.7 14.3 7.9 28.1 12.7 21.4 30.3 9.4 24.6 29.1 9.8 21.0 25.8 19.6 19.3 18.4 14.4 20.6 24.9 27.8 16.2 22.3 19.6 7.9 18.1 25.9 19.9 15.2 20.3 14.7 5.9 11.9 11.0 7.4 14.5 7.4 10.3 11.4 7.9 6.7 13.1 11.4 2.8 18.5 11.5 4.8 8.3 7.9 11.9 15.8 17.3 12.8 12.5 14.1 14.1 12.8 15.0 14.1 12.7 20.6 41.1 70.5 63.1 116.5 46.9 71.0 68.8 28.8 45.5 67.5 41.1 30.9 222.5 40.0 56.0 23.9 47.9 69.6 57.2 30.4 25.4 39.5 40.1 49.8 63.0 44.8 59.3 34.3 122.7 38.9 33.2 69.7 44.4 134.5 54.3 52.6 32.5 53.9 28.0 63.9 136.5 32.9 24.4 27.7 39.7 30.0 44.1 41.8 24.9 96.5 40.5 79.7 68.0 171.4 315.9 44.8 31.5 50.0 55.2 65.5 29.7 21.9 48.2 52.4 52.6 85.0 68.2 92.8 55.1 46.6 87.9 125.7 65.0 41.8 35.0 58.9 USP48 "FLJ11328, FLJ20103, FLJ23054, FLJ23277, MGC14879, USP31" ENSG00000090686 "Ubiquitin specific peptidase 48" Q86UV5 1 21678298-21783606 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Granulosa cells: 200.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030045, HPA030046" Approved Supported Nucleoplasm,Mitochondria,Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 2: Karpas-707 - Immune response" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "Mitochondria, Cytosol" "HPA030045: AB_10670833, HPA030046: AB_10603325" "unprognostic (1.35e-1)" "unprognostic (3.72e-1)" "unprognostic (5.46e-3)" "unprognostic (2.21e-1)" "unprognostic (1.23e-1)" "unprognostic (7.00e-3)" "prognostic unfavorable (6.09e-8)" "unprognostic (1.04e-2)" "unprognostic (3.01e-3)" "unprognostic (9.30e-2)" "unprognostic (7.54e-2)" "unprognostic (4.45e-2)" "unprognostic (4.16e-3)" "unprognostic (2.03e-1)" "unprognostic (1.06e-1)" "unprognostic (5.70e-2)" "unprognostic (2.80e-2)" 25.8 47.5 18.7 26.6 24.5 43.5 26.4 31.0 26.4 26.9 21.6 24.4 21.7 25.3 20.4 23.0 22.3 18.9 21.6 19.3 20.4 18.2 23.8 23.1 35.1 20.1 20.4 31.1 24.6 25.2 26.9 27.3 21.7 23.5 26.0 57.0 31.2 18.6 23.1 29.5 28.7 22.9 18.5 36.0 32.5 20.6 20.8 26.9 28.6 19.5 34.5 23.1 24.6 36.0 43.9 20.5 47.0 34.0 40.1 49.0 46.4 54.0 36.5 35.3 46.6 19.1 43.2 49.1 35.6 48.8 27.5 39.2 59.0 43.4 53.6 48.3 42.1 104.3 75.7 34.5 35.5 53.0 53.7 39.8 36.6 36.1 39.7 48.1 106.1 36.2 83.8 133.2 44.0 21.9 44.2 68.5 29.7 44.5 36.8 61.3 47.2 57.3 40.7 36.2 57.1 35.6 50.4 45.7 122.7 62.3 23.4 63.0 76.1 37.7 30.9 46.7 31.8 105.6 81.7 48.1 36.3 64.5 56.6 82.1 19.5 35.0 12.2 9.4 13.9 28.6 17.8 17.9 21.1 29.8 20.5 13.1 16.8 12.2 10.9 15.3 21.4 12.6 18.7 24.5 31.0 26.4 19.3 20.4 20.1 20.4 21.7 18.5 20.8 36.0 37.9 54.5 42.1 32.0 55.4 22.2 25.1 30.3 33.0 86.5 22.2 24.5 65.3 21.5 24.4 20.2 62.6 61.4 48.3 17.8 25.4 28.5 71.4 33.3 48.5 32.5 21.7 88.1 66.4 20.0 56.3 42.0 33.1 41.4 49.9 200.4 27.5 22.1 29.2 50.5 74.2 31.3 32.6 22.6 28.1 47.7 34.8 34.4 58.7 52.5 55.9 30.7 36.0 54.3 112.3 23.8 16.4 51.6 150.1 20.7 24.1 20.2 27.3 69.2 32.9 51.7 39.8 52.7 47.4 35.1 25.7 32.6 41.8 54.8 31.6 21.6 USP49 MGC20741 ENSG00000164663 "Ubiquitin specific peptidase 49" Q70CQ1 6 41789896-41895361 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "mRNA processing, mRNA splicing, Ubl conjugation pathway" "Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 43.8;Excitatory neurons: 42.8;Inhibitory neurons: 48.6;Oligodendrocyte precursor cells: 56.3;Oligodendrocytes: 31.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in some" 5 "basophil: 5.1" "Lineage enriched" "Detected in single" 8 "granulocytes: 5.1" "Cell line enhanced" "Detected in all" "REH: 46.7;U-698: 63.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030254, HPA030255" Uncertain NA NA "Cluster 10: Basophils - Unknown function" "Cluster 6: Brain - Smell perception" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 56: Bipolar cells - Visual perception" "HPA030254: AB_10600198, HPA030255: AB_10601218" "unprognostic (1.71e-1)" "unprognostic (4.86e-3)" "unprognostic (1.93e-1)" "unprognostic (2.57e-4)" "unprognostic (4.46e-2)" "unprognostic (2.84e-4)" "unprognostic (7.17e-3)" "unprognostic (5.06e-2)" "unprognostic (1.19e-2)" "unprognostic (3.22e-1)" "unprognostic (5.59e-3)" "unprognostic (8.28e-2)" "unprognostic (1.26e-5)" "unprognostic (5.39e-2)" "unprognostic (4.58e-2)" "unprognostic (4.37e-3)" "unprognostic (3.24e-3)" 2.9 2.8 4.3 2.6 3.2 5.3 2.6 6.0 3.8 3.4 0.4 2.6 1.7 2.9 1.6 1.9 2.6 1.6 2.0 3.3 3.7 2.0 1.6 2.7 2.6 2.7 3.9 3.1 2.0 1.5 2.7 1.4 2.5 2.3 1.5 9.3 2.0 1.6 2.9 3.0 1.7 1.6 0.7 2.5 1.8 4.8 4.1 6.7 7.0 1.0 2.5 2.5 2.6 3.8 6.0 1.8 23.6 11.6 2.8 3.0 9.7 2.3 2.2 3.4 4.3 7.5 1.4 24.5 2.5 2.9 4.9 2.6 14.7 2.2 5.1 6.1 11.0 8.8 10.3 2.7 2.0 6.9 5.2 3.1 1.7 5.0 3.1 3.1 2.2 24.9 18.7 6.4 2.6 3.5 26.7 10.5 6.5 6.4 2.2 46.7 11.3 5.4 1.4 4.1 15.8 6.5 3.1 1.1 1.3 5.5 3.5 6.1 6.1 8.1 8.0 2.6 3.1 12.2 11.4 63.9 1.0 6.9 1.5 5.1 0.4 0.6 0.3 0.4 0.2 0.6 0.2 0.3 0.1 0.4 0.4 0.3 1.0 0.4 0.5 0.3 0.2 0.2 4.3 3.2 6.0 3.8 3.3 3.7 2.7 3.9 2.5 0.7 4.1 3.8 2.4 0.0 9.7 20.2 2.0 5.0 3.0 3.9 1.2 27.5 3.6 3.3 4.6 4.3 6.5 5.5 43.8 2.9 4.5 1.4 1.9 1.9 6.5 4.1 5.0 2.8 0.0 8.2 42.8 2.0 1.6 4.3 3.1 4.6 1.3 4.8 1.4 2.1 2.0 15.2 48.6 1.9 4.1 3.1 4.6 7.2 3.7 3.1 3.6 14.0 5.0 2.8 2.1 56.3 31.8 2.6 1.9 6.0 3.0 4.5 2.1 1.1 7.1 10.9 6.6 6.2 3.4 13.3 14.3 2.7 6.3 5.7 2.4 5.1 2.2 4.6 USP5 IsoT ENSG00000111667 "Ubiquitin specific peptidase 5" P45974 12 6852148-6866632 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006756 Uncertain Approved Nucleoplasm,Cytosol NA NA 1200000 "Cluster 27: Non-specific - Gene expression" "Cluster 59: Non-specific - Translation" "Cluster 5: NTERA-2 - Transcription" "Cluster 66: Spermatocytes - Spermatogenesis" "Nucleoplasm, Cytosol" "HPA006756: AB_1080534" "unprognostic (2.19e-1)" "unprognostic (5.83e-2)" "unprognostic (2.48e-1)" "unprognostic (2.57e-1)" "unprognostic (7.60e-2)" "unprognostic (2.21e-2)" "unprognostic (4.02e-2)" "unprognostic (3.93e-2)" "unprognostic (2.57e-1)" "unprognostic (4.71e-2)" "unprognostic (8.90e-3)" "unprognostic (4.69e-2)" "unprognostic (1.17e-2)" "unprognostic (2.65e-2)" "unprognostic (3.56e-1)" "unprognostic (3.23e-1)" "unprognostic (2.02e-3)" 27.1 37.9 23.7 26.7 26.1 22.8 19.5 15.5 38.0 24.1 2.4 31.3 25.3 31.5 17.4 38.2 25.9 18.5 33.0 25.3 33.6 20.1 23.1 20.5 29.2 31.0 31.3 19.4 17.8 41.4 27.8 25.4 38.8 26.5 22.2 15.7 20.0 29.6 66.7 48.1 26.1 35.5 15.0 21.2 22.9 40.9 28.9 36.5 26.7 42.5 29.4 29.8 24.2 29.0 88.1 135.7 88.4 100.4 59.0 53.9 113.4 93.0 70.9 109.2 78.8 129.4 84.9 105.7 47.6 98.5 86.5 75.2 98.6 92.7 69.5 198.6 84.0 97.1 105.5 71.0 45.8 88.5 97.2 55.6 52.9 94.8 64.9 72.9 94.8 41.7 85.4 40.9 91.1 97.4 132.9 44.4 172.8 89.3 56.5 103.4 115.5 73.5 62.9 84.5 48.5 97.4 63.5 96.3 41.1 110.6 38.3 72.4 92.4 91.5 109.1 70.4 117.6 49.0 124.5 163.8 102.1 55.3 91.3 5.4 19.3 8.3 24.3 25.1 23.1 15.0 21.7 20.8 28.4 13.9 20.1 20.9 1.3 17.6 24.4 20.5 19.9 27.7 23.7 26.1 15.5 38.0 25.3 33.6 31.0 31.3 38.8 15.0 28.9 29.0 11.3 9.6 13.1 7.5 14.0 11.6 11.4 18.0 8.6 18.7 13.1 10.8 9.5 17.2 11.5 22.0 60.5 45.9 14.8 21.5 11.7 28.1 14.7 10.6 14.7 15.3 16.7 19.4 11.5 20.5 30.7 16.6 10.2 13.7 14.7 29.6 11.4 22.2 28.4 40.4 11.9 19.3 14.2 13.0 7.4 19.2 23.0 10.9 16.0 9.4 32.4 16.0 13.4 6.0 11.9 20.2 17.4 33.8 14.1 10.3 22.5 18.5 7.9 16.2 32.9 13.3 17.2 51.7 25.6 17.6 15.5 52.8 15.4 27.6 27.5 7.9 USP51 ENSG00000247746 "Ubiquitin specific peptidase 51" Q70EK9 X 55484616-55489202 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "epididymis: 51.7" "Cell type enhanced" "Detected in many" "Bipolar cells: 23.7;Muller glia cells: 32.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "SuSa: 7.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA001942 Uncertain Approved "Nucleoli fibrillar center,Cytosol" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 68: Epididymis - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 5: Muller glia cells - Visual perception" Cytosol "Nucleoli fibrillar center" "HPA001942: AB_1080536" "unprognostic (1.19e-2)" "unprognostic (4.65e-2)" "unprognostic (3.67e-2)" "unprognostic (1.02e-3)" "unprognostic (8.08e-2)" "unprognostic (3.26e-1)" "unprognostic (3.17e-3)" "unprognostic (2.07e-3)" "unprognostic (5.69e-2)" "prognostic favorable (5.70e-4)" "unprognostic (1.01e-3)" "unprognostic (1.27e-1)" "prognostic favorable (2.63e-5)" "unprognostic (2.81e-3)" "unprognostic (5.92e-2)" "unprognostic (5.85e-2)" "unprognostic (1.63e-1)" 1.4 3.1 2.5 0.9 2.7 0.5 1.7 2.8 2.8 1.9 4.2 0.8 0.4 3.1 51.7 0.6 5.5 0.8 2.1 2.2 4.2 3.7 1.2 1.5 1.1 2.2 3.1 6.5 1.1 5.6 1.4 2.4 2.4 2.4 0.8 3.1 0.8 2.5 0.4 1.1 0.7 1.9 2.5 1.8 0.8 2.3 3.8 2.4 5.3 1.1 1.2 0.9 0.7 2.5 0.0 0.6 3.9 1.1 1.9 1.0 0.0 0.6 0.3 0.7 0.9 1.2 0.5 0.0 4.6 0.8 0.8 0.2 1.0 0.4 1.2 1.3 0.0 1.0 0.2 0.0 0.8 2.5 0.2 3.9 0.0 0.4 0.0 0.3 0.2 3.0 3.1 3.0 0.6 2.6 2.4 1.3 4.8 0.0 0.2 3.4 0.7 1.5 0.9 0.1 0.0 0.7 1.1 0.1 3.7 7.0 0.9 1.3 0.2 1.5 2.1 0.4 0.1 4.7 2.0 0.9 1.0 1.4 1.0 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.5 2.7 2.8 2.8 2.2 4.2 2.2 3.1 2.4 2.5 3.8 2.5 5.1 3.2 5.5 3.3 2.6 0.9 2.2 0.9 2.2 23.7 3.8 7.4 6.9 1.5 2.0 3.7 6.2 4.3 1.2 0.2 9.8 1.5 0.3 9.0 9.2 6.0 3.6 5.0 2.7 0.0 2.2 8.1 0.0 2.1 1.3 7.9 6.4 0.7 7.6 6.7 5.0 0.5 0.0 5.6 2.5 1.0 4.1 4.7 5.4 1.9 0.3 32.9 3.1 3.5 3.7 0.2 0.3 8.2 1.0 1.0 0.0 13.1 11.2 16.4 0.0 7.1 5.0 11.4 12.5 1.0 0.4 2.7 3.1 13.0 0.4 0.5 USP6 "HRP1, Tre-2, TRE17, Tre2, TRESMCR" ENSG00000129204 "Ubiquitin specific peptidase 6" P35125 17 5116032-5175034 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Calmodulin-binding, Hydrolase, Protease, Thiol protease" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "skeletal muscle: 19.6;testis: 13.4" "Cell type enhanced" "Detected in many" "Early spermatids: 24.4;Spermatocytes: 26.9" "Cancer enriched" "Detected in single" 14 "testis cancer: 2.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA046969 Uncertain Vesicles NA NA "Cluster 23: Testis - Cell cycle regulation" "Cluster 37: Myocytes - Muscle contraction" Vesicles "HPA046969: " "unprognostic (3.89e-2)" "unprognostic (3.79e-3)" "unprognostic (2.50e-1)" "unprognostic (1.85e-1)" "unprognostic (9.32e-2)" "unprognostic (3.50e-3)" "unprognostic (1.29e-1)" "unprognostic (1.67e-2)" "unprognostic (3.45e-2)" "unprognostic (2.46e-2)" "unprognostic (7.91e-4)" "unprognostic (6.28e-3)" "unprognostic (3.24e-4)" "unprognostic (3.75e-2)" "unprognostic (3.13e-1)" "unprognostic (2.71e-1)" "unprognostic (7.09e-4)" 0.4 0.3 0.2 0.2 0.5 0.1 0.7 0.3 0.6 1.4 1.5 0.8 0.0 0.9 0.7 0.2 0.5 0.5 0.4 0.4 0.3 0.6 0.1 0.4 0.3 0.7 0.2 2.6 0.3 0.0 0.6 0.5 0.6 0.6 0.3 2.5 0.5 0.4 19.6 0.6 0.3 0.9 0.2 0.4 0.2 13.4 0.5 0.0 0.9 0.6 0.2 0.3 0.5 0.9 0.1 0.1 0.3 0.2 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.1 0.2 0.2 0.1 0.1 0.1 0.2 0.0 0.0 0.0 0.3 0.2 0.1 0.3 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.1 0.2 0.1 0.0 0.2 0.4 0.3 0.1 0.1 0.0 0.3 0.2 0.0 0.3 0.2 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.5 0.3 0.6 0.4 0.3 0.7 0.2 0.6 0.2 0.5 0.9 2.0 6.4 10.8 0.0 0.4 10.8 1.0 1.1 0.0 8.5 4.0 3.8 1.6 5.7 3.5 3.7 12.5 0.6 1.0 0.1 3.9 0.0 24.4 1.1 2.1 3.0 0.0 5.3 1.2 0.0 0.8 1.8 0.0 1.4 0.0 1.2 3.6 3.2 2.7 1.7 1.0 0.0 0.0 5.4 6.4 13.5 1.8 3.1 3.6 2.8 3.2 5.1 0.0 0.0 2.9 0.1 0.1 2.6 0.1 2.1 0.0 3.2 4.0 12.3 6.6 5.9 1.7 26.9 11.5 0.0 10.4 0.7 1.1 0.9 0.2 1.1 USP7 HAUSP ENSG00000187555 "Ubiquitin specific peptidase 7" Q93009 16 8892097-8975328 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Biological rhythms, DNA damage, DNA repair, Host-virus interaction, Ubl conjugation pathway" "Developmental protein, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 282.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008108, HPA015641, CAB079904" Approved Supported "Nucleoplasm,Nuclear bodies" NA NA 16000 "Cluster 44: Non-specific - Transcription" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Nucleoplasm "Nuclear bodies" "CAB008108: AB_2233500, CAB079904: AB_2552261, HPA015641: AB_1858700" "unprognostic (6.73e-2)" "unprognostic (1.59e-1)" "unprognostic (3.36e-3)" "unprognostic (1.94e-2)" "unprognostic (9.64e-2)" "unprognostic (8.09e-2)" "unprognostic (4.69e-2)" "unprognostic (4.56e-2)" "unprognostic (4.81e-1)" "unprognostic (2.49e-1)" "unprognostic (2.35e-1)" "unprognostic (9.93e-2)" "prognostic favorable (8.56e-5)" "unprognostic (1.35e-1)" "unprognostic (1.07e-1)" "unprognostic (7.31e-2)" "unprognostic (2.69e-1)" 22.3 16.1 17.6 27.0 19.8 54.6 20.5 20.5 20.7 20.1 15.1 33.1 21.8 21.5 10.1 29.6 19.0 19.9 23.8 21.4 18.1 19.5 25.1 19.3 39.9 16.9 20.1 19.8 26.7 34.8 13.9 23.7 17.5 20.7 32.5 21.7 18.7 18.7 45.2 25.4 25.9 25.7 18.7 24.2 25.5 58.8 18.8 51.1 22.8 41.0 44.9 26.3 17.7 20.8 39.9 73.5 62.2 46.9 34.9 42.9 42.9 53.6 44.7 48.1 40.4 66.6 46.7 94.6 33.8 61.0 27.7 48.8 95.2 61.9 79.6 63.1 38.1 78.4 49.5 132.9 49.0 87.6 48.8 37.3 37.7 52.6 61.0 37.0 69.7 139.8 77.7 101.5 49.6 75.4 130.8 16.9 43.9 49.8 41.4 114.5 69.7 86.2 33.4 77.9 58.8 35.5 59.4 55.3 28.7 62.3 55.0 39.4 60.4 52.1 54.1 80.3 40.4 49.1 134.3 145.1 48.5 49.6 43.5 5.2 2.1 2.8 4.5 2.2 5.7 4.0 4.1 5.3 2.2 4.9 4.9 4.3 3.4 2.8 6.1 6.5 5.1 1.1 17.6 19.8 20.5 20.7 21.4 18.1 16.9 20.1 17.5 18.7 18.8 20.8 40.4 35.3 54.5 22.2 38.0 46.5 23.1 17.9 22.8 51.1 29.7 28.8 74.3 21.5 36.4 29.5 25.0 21.9 51.4 39.8 5.9 22.5 282.4 38.5 50.9 35.8 42.2 46.5 31.4 33.4 14.5 34.4 31.1 57.6 26.6 47.8 25.0 37.5 19.8 43.7 34.9 49.3 10.2 29.2 31.0 112.2 25.4 43.8 19.6 21.5 36.3 29.2 24.7 24.1 30.2 35.6 39.0 34.6 46.8 34.1 31.3 13.7 37.8 44.2 6.6 58.4 39.4 33.8 39.4 41.3 50.0 21.1 40.4 47.6 54.8 35.0 USP8 "HumORF8, KIAA0055, SPG59, UBPY" ENSG00000138592 "Ubiquitin specific peptidase 8" P40818 15 50424380-50514421 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Cancer-related genes, Cushing syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA050215 Approved Supported "Golgi apparatus,Cytosol" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 18: U-2197 - ECM organization" "Cluster 66: Spermatocytes - Spermatogenesis" "Golgi apparatus" Cytosol "HPA050215: AB_2681054" "unprognostic (5.81e-2)" "unprognostic (1.34e-1)" "unprognostic (1.46e-1)" "unprognostic (9.58e-2)" "unprognostic (2.35e-2)" "unprognostic (2.91e-1)" "unprognostic (1.42e-1)" "unprognostic (3.96e-1)" "unprognostic (1.68e-2)" "unprognostic (5.08e-2)" "unprognostic (2.94e-1)" "unprognostic (3.99e-2)" "prognostic favorable (1.29e-5)" "unprognostic (4.89e-2)" "unprognostic (1.13e-1)" "unprognostic (3.79e-1)" "unprognostic (1.58e-1)" 20.3 18.8 11.5 21.1 11.0 27.6 19.6 14.4 13.3 20.5 18.1 21.5 26.7 19.1 10.4 20.7 18.5 16.4 15.1 9.1 14.6 27.0 28.1 19.5 19.0 14.1 13.1 19.9 17.4 45.1 10.6 20.3 12.5 17.0 20.8 22.2 19.8 17.2 17.6 14.2 24.4 18.4 11.5 18.7 22.5 32.0 13.6 20.9 25.4 22.7 24.3 20.0 12.6 13.2 30.6 35.8 23.7 41.1 32.3 44.3 31.0 45.7 43.9 35.7 40.4 19.5 17.7 28.8 35.0 43.5 46.6 57.8 28.8 28.3 39.9 27.2 19.3 52.9 31.9 27.3 35.9 34.3 34.4 32.4 36.2 26.0 55.8 37.0 36.3 23.3 28.4 36.8 32.9 45.9 26.6 12.0 28.5 32.6 17.1 24.1 39.1 45.8 29.5 61.3 29.1 23.8 42.5 55.9 57.4 48.9 35.8 36.9 45.0 41.1 24.1 122.7 52.7 28.5 69.8 32.4 30.6 65.6 40.1 114.6 27.7 50.1 21.4 26.1 22.1 37.3 22.9 23.3 22.7 34.3 24.0 21.2 47.9 22.1 35.0 20.5 20.0 16.0 11.5 11.0 14.4 13.3 9.1 14.6 14.1 13.1 12.5 11.5 13.6 13.2 63.5 96.1 130.8 36.2 101.8 28.9 40.7 47.3 35.9 54.5 41.7 40.0 69.8 51.5 72.7 47.8 68.8 59.0 92.7 79.5 25.4 53.7 153.7 91.5 79.7 53.8 53.3 36.8 41.0 51.3 45.4 55.8 58.1 65.6 86.7 48.5 51.0 56.6 45.4 33.7 44.3 68.7 36.7 73.2 38.2 28.4 53.7 77.6 40.9 46.9 85.3 45.5 72.1 34.7 46.1 57.3 58.2 61.7 87.1 51.0 88.9 49.9 114.9 74.2 46.0 108.2 56.2 140.5 54.8 39.6 41.5 105.2 72.6 77.1 64.8 55.3 USP9X "DFFRX, FAF, MRX99" ENSG00000124486 "Ubiquitin specific peptidase 9 X-linked" Q93008 X 41085445-41236579 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, Cell cycle, Cell division, Chromosome partition, Mitosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011618, HPA047417, CAB070164" Approved Uncertain Vesicles NA NA 24000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Vesicles "CAB011618: AB_470860, CAB070164: AB_10011071, HPA047417: " "unprognostic (5.42e-3)" "unprognostic (6.42e-2)" "unprognostic (3.19e-3)" "unprognostic (2.94e-2)" "unprognostic (5.99e-2)" "unprognostic (4.76e-1)" "unprognostic (1.82e-2)" "unprognostic (4.07e-1)" "unprognostic (1.90e-1)" "unprognostic (1.72e-1)" "unprognostic (7.07e-2)" "unprognostic (1.09e-1)" "unprognostic (5.82e-2)" "unprognostic (1.59e-1)" "unprognostic (4.19e-2)" "unprognostic (2.78e-1)" "unprognostic (1.33e-1)" 16.4 16.8 11.9 14.3 13.9 18.2 14.2 12.7 12.8 15.3 14.3 14.8 13.6 15.4 14.9 14.1 16.0 13.0 15.3 14.3 13.2 17.8 33.9 14.4 15.8 12.2 13.1 13.4 16.0 30.0 10.2 18.4 13.8 12.3 13.7 22.0 11.5 15.3 39.1 13.8 14.3 16.3 12.5 13.3 13.8 17.5 12.8 18.8 19.5 28.4 16.2 15.0 12.6 16.4 38.6 44.2 39.1 40.2 33.0 32.7 8.8 21.5 28.8 23.8 27.5 21.1 16.9 25.7 11.5 48.5 71.3 25.3 67.1 39.7 39.7 32.0 50.5 29.3 41.3 19.9 27.6 26.4 21.0 29.3 17.9 56.4 53.4 35.5 37.2 17.1 36.0 20.3 38.6 29.1 18.8 12.7 42.6 14.1 24.7 20.3 51.8 16.9 24.7 30.7 22.2 20.8 89.0 26.7 26.0 69.8 24.3 16.2 40.2 36.6 27.6 34.6 24.0 19.1 22.3 30.9 26.4 12.1 18.5 1.7 2.3 3.0 2.5 1.9 3.6 2.8 3.0 2.7 2.6 2.1 3.0 2.8 6.4 2.5 2.5 2.1 2.8 1.5 11.9 13.9 12.7 12.8 14.3 13.2 12.2 13.1 13.8 12.5 12.8 16.4 38.1 41.7 35.1 48.0 42.6 48.3 30.8 29.6 55.2 38.1 41.3 29.5 83.5 54.3 37.9 27.6 37.5 39.6 46.3 58.5 7.9 28.4 14.9 85.5 56.9 43.6 26.9 41.0 84.9 26.5 25.4 41.4 41.8 136.9 25.9 58.3 45.7 62.8 32.6 37.0 86.0 39.1 18.3 47.8 42.1 15.4 33.2 55.5 33.8 67.5 44.6 31.3 30.9 74.9 108.0 32.6 40.1 49.2 38.8 35.6 47.7 21.5 35.8 31.2 32.9 70.6 48.3 86.4 82.9 55.2 55.3 46.7 42.4 45.8 38.0 40.2 USP9Y "AZFA, DFFRY" ENSG00000114374 "Ubiquitin specific peptidase 9 Y-linked" O00507 Y 12537650-12860839 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 64.6;Excitatory neurons: 89.5;Inhibitory neurons: 69.5" "Cancer enhanced" "Detected in many" "prostate cancer: 5.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "RPTEC TERT1: 21.5;RT4: 17.4" "Not detected" "Not detected" HPA057687 Uncertain Vesicles NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 54: Non-specific - Microtubule organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Vesicles "HPA057687: " "unprognostic (2.63e-1)" "unprognostic (8.97e-2)" "unprognostic (1.10e-5)" "unprognostic (8.46e-3)" "unprognostic (4.93e-2)" "unprognostic (2.53e-2)" "unprognostic (2.77e-1)" "unprognostic (3.17e-2)" "unprognostic (1.71e-1)" "unprognostic (4.05e-2)" "unprognostic (1.41e-4)" "unprognostic (2.28e-1)" "unprognostic (1.19e-2)" "unprognostic (1.42e-1)" 3.6 5.2 1.3 1.7 1.4 2.6 3.3 2.8 5.2 0.0 2.5 4.5 1.7 0.0 7.2 5.2 0.0 4.6 5.5 1.3 1.4 7.1 3.0 5.2 2.2 1.2 1.1 0.0 6.0 3.5 8.8 2.3 1.3 9.7 4.9 12.9 4.9 7.0 5.2 3.2 4.4 0.0 1.0 5.1 3.9 4.2 1.4 0.0 5.7 9.7 5.6 4.5 0.0 2.4 0.0 4.7 0.0 0.0 0.0 0.0 5.3 14.2 14.6 7.2 8.5 0.0 0.0 7.7 0.0 12.2 0.0 0.0 0.0 0.0 8.6 8.1 0.0 7.3 0.0 9.5 5.8 0.0 0.0 9.7 8.9 0.0 0.0 0.0 0.0 3.0 0.0 0.0 12.2 0.0 9.8 0.0 4.6 0.0 0.0 0.0 3.5 2.1 21.5 17.4 7.2 0.0 0.0 0.0 4.4 12.5 0.0 0.2 10.6 9.5 0.0 0.0 7.0 0.0 9.7 15.1 0.5 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.9 0.4 0.7 0.5 0.1 0.7 0.8 0.5 0.0 0.1 0.0 0.6 0.6 0.0 1.3 1.4 2.8 5.2 1.3 1.4 1.2 1.1 1.3 1.0 1.4 2.4 0.0 25.6 23.5 29.4 11.0 11.7 8.5 9.5 18.2 23.6 0.0 0.0 26.5 7.2 12.6 20.2 64.6 6.3 5.3 0.3 1.9 6.9 0.5 0.0 0.0 5.8 0.0 5.9 89.5 0.0 1.7 8.1 6.6 0.0 2.5 0.0 6.1 2.3 3.1 26.9 69.5 1.1 8.2 5.6 9.3 1.1 12.5 3.6 3.6 31.9 3.6 8.8 14.4 28.6 17.4 2.3 0.0 15.4 4.1 13.2 0.7 6.3 19.9 23.1 0.0 5.2 4.4 2.8 2.6 20.6 11.6 3.4 14.7 0.0 1.5 11.9 VKORC1 VKCFD2 ENSG00000167397 "Vitamin K epoxide reductase complex subunit 1" Q9BQB6 16 31090842-31095980 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Oxidoreductase "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 454.9" "Cell type enhanced" "Detected in all" "Hepatocytes: 749.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "ASC diff: 638.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042720 Approved Supported "Endoplasmic reticulum" "Intracellular and membrane" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 85: Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 2: Hepatocytes - Metabolism" "Endoplasmic reticulum" "HPA042720: AB_10961864" "unprognostic (5.99e-2)" "unprognostic (2.98e-1)" "unprognostic (7.11e-3)" "unprognostic (7.68e-3)" "unprognostic (5.49e-2)" "unprognostic (3.23e-3)" "unprognostic (3.02e-2)" "unprognostic (2.32e-2)" "unprognostic (2.42e-1)" "unprognostic (2.66e-1)" "unprognostic (1.04e-1)" "unprognostic (1.19e-1)" "prognostic unfavorable (2.09e-10)" "unprognostic (1.11e-2)" "unprognostic (6.65e-2)" "unprognostic (3.12e-2)" "unprognostic (9.66e-2)" 99.4 107.6 56.0 38.4 60.4 55.2 87.0 60.3 73.5 111.0 64.9 97.0 44.2 109.9 87.2 51.8 90.8 58.9 99.1 57.4 59.3 122.7 454.9 77.4 35.8 64.4 59.5 115.1 168.0 51.3 115.7 45.6 63.8 76.3 41.1 23.0 92.4 69.8 34.4 81.1 82.3 84.7 59.9 62.2 88.1 55.6 68.5 35.0 76.3 32.2 32.6 100.6 88.0 64.8 73.6 187.7 57.2 165.4 638.0 389.6 68.2 269.0 229.3 128.9 218.5 79.0 83.3 54.9 141.6 331.6 87.2 66.2 79.4 103.5 139.5 81.9 204.8 52.5 239.9 378.2 103.1 104.1 74.1 225.0 54.2 173.4 146.6 336.8 141.0 78.2 70.3 130.6 253.6 271.1 74.4 205.9 106.8 98.0 175.9 132.7 160.3 286.8 127.7 61.8 119.5 146.9 118.7 84.2 137.8 91.2 138.3 123.9 126.8 171.1 61.5 159.6 101.9 76.1 80.2 50.7 445.8 174.5 90.8 77.0 127.5 196.2 118.1 94.7 116.8 91.7 116.7 119.4 127.6 102.6 102.9 101.4 104.0 84.2 98.2 157.4 143.1 112.8 56.0 60.4 60.3 73.5 57.4 59.3 64.4 59.5 63.8 59.9 68.5 64.8 95.1 57.7 51.0 5.9 30.6 84.6 68.0 157.0 10.8 12.3 93.3 117.3 20.9 141.5 64.3 108.5 8.4 85.7 48.1 34.3 62.6 204.2 6.1 25.8 83.7 89.5 67.1 32.4 8.8 129.4 293.6 132.8 10.7 48.8 55.3 60.3 118.9 749.9 184.1 10.1 7.5 44.2 46.8 80.1 94.3 13.9 158.1 66.9 115.6 5.6 107.4 68.8 51.5 6.6 17.6 103.8 28.2 172.3 29.5 59.5 152.9 204.6 33.4 19.3 59.2 78.4 99.8 30.6 34.2 10.7 112.0 39.5 39.7 82.4 49.0 55.2 VNN3 HSA238982 ENSG00000093134 "Vanin 3" Q9NY84 6 132722787-132736935 "Enzymes, Metabolic proteins, Predicted secreted proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "bone marrow: 34.9;liver: 34.7" "Cell type enhanced" "Detected in some" "Basal respiratory cells: 20.7;Club cells: 42.5;Gastric mucus-secreting cells: 15.8;Respiratory ciliated cells: 86.1" "Cancer enriched" "Detected in some" 4 "liver cancer: 3.9" "Not detected" "Not detected" "Immune cell enriched" "Detected in some" 4 "neutrophil: 76.2" "Lineage enriched" "Detected in many" 33 "granulocytes: 76.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted to blood" NA NA 150000000 "Cluster 50: Neutrophils - Cellular senescence" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "unprognostic (3.20e-2)" "unprognostic (2.70e-1)" "unprognostic (7.92e-3)" "unprognostic (1.71e-2)" "unprognostic (3.05e-3)" "unprognostic (1.06e-3)" "unprognostic (1.19e-1)" "unprognostic (1.01e-1)" "unprognostic (2.42e-2)" "unprognostic (7.68e-2)" "unprognostic (1.20e-1)" "unprognostic (1.63e-1)" "unprognostic (5.84e-8)" "unprognostic (1.25e-2)" "unprognostic (1.52e-1)" "unprognostic (9.32e-2)" "unprognostic (1.56e-1)" 1.2 0.1 0.1 2.2 0.1 34.9 0.2 0.1 0.5 1.6 0.2 0.1 0.0 0.1 0.0 0.8 1.9 1.0 0.4 0.1 0.1 0.3 34.7 4.5 0.4 0.1 0.1 0.0 0.1 0.0 0.1 1.3 0.2 0.3 0.0 0.0 1.0 0.1 0.1 0.2 0.2 0.2 0.1 5.5 0.4 0.1 0.2 0.4 0.1 1.1 0.4 0.5 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.7 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 76.2 0.0 0.1 0.0 0.0 0.3 0.1 0.1 0.1 0.5 0.1 0.1 0.1 0.1 0.2 0.1 0.2 0.1 0.0 0.0 2.8 0.0 0.0 0.0 0.1 20.7 0.0 0.0 0.2 0.0 0.4 0.0 42.5 0.0 0.0 0.0 0.1 0.2 0.0 3.7 0.2 2.3 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.8 15.8 1.7 0.0 0.0 0.4 10.0 0.1 0.0 0.0 0.0 6.1 5.8 0.0 0.2 0.0 3.6 0.0 0.0 4.5 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.1 2.0 0.0 0.1 86.1 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 1.0 0.2 0.2 0.3 4.1 VRK1 ENSG00000100749 "VRK serine/threonine kinase 1" Q99986 14 96797304-96954846 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" Neurodegeneration "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 50.4;testis: 37.1" "Cell type enhanced" "Detected in all" "Spermatocytes: 198.9;Spermatogonia: 110.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000660, HPA017929" Enhanced Supported Nucleoplasm,Cytosol Yes No "Cluster 15: NK-cells - Transcription" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm Cytosol "HPA000660: AB_1080579, HPA017929: AB_1858770" "unprognostic (1.03e-1)" "unprognostic (1.17e-2)" "unprognostic (1.84e-2)" "unprognostic (2.24e-3)" "unprognostic (5.42e-2)" "unprognostic (1.19e-2)" "prognostic unfavorable (4.15e-4)" "unprognostic (4.20e-2)" "unprognostic (2.11e-2)" "unprognostic (5.47e-2)" "unprognostic (5.14e-2)" "unprognostic (1.60e-1)" "unprognostic (2.53e-2)" "unprognostic (6.70e-2)" "unprognostic (4.56e-2)" "unprognostic (3.36e-2)" "unprognostic (1.58e-1)" 5.9 5.2 5.9 12.8 7.1 50.4 11.5 6.0 7.9 5.2 4.3 10.8 6.5 6.5 6.9 8.9 9.2 4.4 5.2 5.9 5.1 4.9 5.5 4.9 27.1 5.3 5.5 6.0 3.2 5.4 3.1 7.6 5.4 5.0 12.3 4.4 4.3 5.0 4.7 7.4 7.2 6.7 4.8 11.3 6.5 37.1 5.9 35.5 5.9 4.6 27.9 7.7 5.4 7.0 52.4 27.0 78.5 30.2 9.2 14.9 44.8 42.8 34.4 67.1 65.4 36.0 54.7 139.2 22.4 24.3 39.2 56.5 75.5 54.4 90.5 73.4 36.4 90.5 18.7 39.3 10.2 168.5 49.2 8.5 9.7 50.4 32.6 12.8 47.0 104.8 76.6 79.0 56.9 65.5 137.1 76.5 47.8 39.9 59.3 124.5 134.2 48.6 32.3 59.3 53.2 28.0 34.2 36.4 30.8 36.0 39.3 66.6 24.4 27.9 22.8 47.7 37.3 37.7 53.5 124.8 44.7 74.6 34.8 42.7 12.3 26.2 21.5 15.5 29.0 31.3 24.9 26.4 15.7 32.7 27.1 27.3 6.5 45.6 15.2 21.4 34.9 19.4 5.9 7.1 6.0 7.9 5.9 5.1 5.3 5.5 5.4 4.8 5.9 7.0 15.3 3.2 4.6 6.8 30.6 16.8 13.8 23.3 6.2 12.4 9.3 11.3 11.8 12.8 16.7 14.7 8.4 34.8 24.8 6.3 11.7 13.5 21.3 21.1 8.3 12.4 3.0 76.2 42.0 19.4 48.3 11.4 14.8 10.8 28.5 20.0 7.1 3.3 19.2 10.1 36.2 10.4 20.3 11.8 14.9 11.5 5.6 12.0 12.4 19.7 14.2 6.2 27.8 12.1 19.8 10.3 2.2 9.8 25.4 6.1 3.0 11.2 37.6 9.6 19.7 14.3 15.1 198.9 110.9 14.1 13.9 15.1 26.8 9.2 18.1 10.4 VRK2 ENSG00000028116 "VRK serine/threonine kinase 2" Q86Y07 2 57907629-58159920 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Host-virus interaction" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in many" 9 "Oligodendrocytes: 540.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB046459, HPA047503" Approved Supported "Endoplasmic reticulum" NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 70: Brain - Nervous system development" "Cluster 44: HDLM-2 - Immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Endoplasmic reticulum" "CAB046459: AB_1858773, HPA047503: AB_2680071" "unprognostic (1.87e-1)" "unprognostic (5.84e-2)" "unprognostic (4.65e-2)" "unprognostic (1.33e-3)" "unprognostic (1.27e-1)" "unprognostic (1.60e-2)" "prognostic unfavorable (6.32e-6)" "unprognostic (3.90e-2)" "unprognostic (4.76e-2)" "unprognostic (2.96e-2)" "prognostic unfavorable (4.65e-4)" "unprognostic (1.36e-1)" "prognostic unfavorable (4.66e-5)" "unprognostic (3.48e-1)" "unprognostic (1.62e-1)" "unprognostic (2.99e-1)" "unprognostic (3.56e-1)" 14.8 13.2 14.9 20.2 26.4 18.8 17.2 15.1 16.2 10.8 9.3 14.0 10.9 15.3 16.7 19.5 13.4 11.9 15.6 12.8 16.0 10.7 16.8 15.9 22.5 23.9 21.1 10.7 19.7 14.7 7.6 14.6 23.0 14.2 16.4 4.8 13.8 11.4 14.3 13.3 11.0 19.4 14.8 18.0 13.7 13.3 18.9 12.7 18.6 15.1 26.0 14.7 12.6 40.6 37.1 24.3 2.7 16.3 16.7 30.6 48.4 32.8 33.3 22.7 22.9 49.8 38.5 44.3 43.0 29.8 37.1 27.4 34.9 36.7 33.7 80.9 23.1 50.9 19.0 35.8 27.8 44.1 29.0 17.7 42.6 36.3 52.8 26.1 64.9 6.2 50.2 28.5 38.2 21.2 0.3 32.9 29.9 56.9 11.6 49.4 12.0 30.6 36.8 30.2 9.4 0.3 52.5 31.2 27.5 26.2 22.0 26.1 37.0 0.5 74.4 20.6 0.6 40.5 33.9 24.0 18.2 52.7 38.4 31.0 24.5 35.3 15.1 32.2 18.4 30.6 14.2 17.7 25.5 31.7 10.6 13.6 9.0 18.7 34.3 26.4 18.5 15.4 14.9 26.4 15.1 16.2 12.8 16.0 23.9 21.1 23.0 14.8 18.9 40.6 17.9 22.4 11.2 1.3 26.4 9.8 12.6 21.8 14.8 1.0 14.0 10.2 21.8 7.2 22.4 18.4 0.0 21.2 13.7 6.5 15.6 27.1 23.0 12.7 10.9 15.8 6.6 39.1 2.7 26.2 21.1 14.0 16.3 12.7 17.7 9.6 8.9 8.4 18.4 0.0 4.7 5.1 30.5 19.1 19.1 8.4 5.9 26.2 10.6 54.4 41.7 5.3 16.5 32.2 540.8 24.8 8.7 6.0 25.7 18.4 2.5 9.5 30.7 4.0 6.6 7.4 14.3 22.0 10.9 19.2 8.4 19.4 16.5 6.8 7.9 16.4 VRK3 ENSG00000105053 "VRK serine/threonine kinase 3" Q8IV63 19 49976468-50025946 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 135.6" "Group enriched" "Detected in all" 7 "Early spermatids: 557.6;Late spermatids: 1646.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056489 Approved Supported Nucleoplasm,Vesicles NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 21: OE19 - Mitochondria" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Vesicles" "HPA056489: AB_2683150" "unprognostic (2.09e-1)" "unprognostic (3.14e-2)" "unprognostic (1.26e-1)" "unprognostic (4.94e-3)" "unprognostic (1.23e-1)" "unprognostic (2.22e-3)" "unprognostic (9.78e-2)" "unprognostic (3.47e-1)" "unprognostic (8.79e-2)" "unprognostic (2.48e-1)" "unprognostic (1.31e-2)" "unprognostic (1.43e-1)" "prognostic favorable (1.83e-4)" "unprognostic (9.38e-2)" "unprognostic (2.15e-1)" "unprognostic (1.06e-1)" "prognostic favorable (5.66e-4)" 17.4 23.3 25.9 17.6 26.6 23.6 17.7 26.1 28.6 17.9 30.2 21.9 25.8 15.9 19.5 17.6 33.2 20.9 17.5 25.4 27.9 36.5 35.6 16.9 28.5 27.6 31.1 21.2 22.1 15.9 20.6 16.9 30.4 20.2 22.0 64.8 21.9 15.4 26.9 16.8 32.9 14.1 25.2 26.0 21.6 135.6 27.9 35.6 19.7 17.4 25.7 18.0 16.8 29.3 31.0 31.3 22.6 24.5 29.2 26.9 23.3 21.7 25.7 31.6 34.5 16.8 33.7 37.1 15.2 21.2 22.1 22.5 21.3 18.6 25.5 32.6 43.5 28.9 20.4 29.4 21.9 36.7 48.7 24.2 27.3 18.3 19.2 28.4 26.5 39.9 35.8 53.7 23.2 13.0 49.7 24.5 12.2 54.6 26.7 39.3 23.9 47.6 27.2 32.2 25.3 12.3 21.5 26.0 24.7 20.0 23.9 38.5 20.2 32.2 18.6 13.1 17.1 34.3 47.4 19.6 25.8 22.3 22.5 110.0 42.8 81.1 53.7 46.1 43.3 58.9 48.7 51.9 47.9 53.3 49.2 45.3 112.5 82.7 55.1 45.4 76.1 48.4 25.9 26.6 26.1 28.6 25.4 27.9 27.6 31.1 30.4 25.2 27.9 29.3 19.6 6.4 28.6 10.1 26.6 6.6 16.0 27.2 6.8 34.3 17.9 14.5 8.4 24.3 29.8 14.7 143.9 43.8 27.9 49.9 31.3 31.0 557.6 50.7 12.0 16.0 22.2 38.7 13.9 32.7 38.6 15.5 18.8 26.8 18.3 24.1 28.5 44.5 34.8 32.0 15.9 35.4 34.6 25.4 9.3 1646.8 22.1 22.9 14.2 6.5 40.6 33.2 41.2 10.1 15.3 34.2 67.9 25.9 18.6 20.6 87.5 91.4 71.8 116.0 13.1 12.0 15.2 142.8 52.6 10.5 10.9 57.3 28.0 24.9 36.0 30.1 WEE1 WEE1A ENSG00000166483 "WEE1 G2 checkpoint kinase" P30291 11 9573670-9593457 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 213.9;Glandular and luminal cells: 262.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB004619, HPA068845" Approved Approved Nucleoli No No "Cluster 43: B-cells - Humoral immune response" "Cluster 46: Fibroblasts - ECM organization" "Cluster 28: BEWO - Transcription regulation" "Cluster 44: Endometrium - Transcription" Nucleoli "CAB004619: AB_628447, HPA068845: AB_2686048" "unprognostic (6.04e-2)" "unprognostic (1.90e-3)" "unprognostic (1.09e-2)" "unprognostic (9.29e-2)" "unprognostic (1.26e-1)" "unprognostic (1.39e-2)" "unprognostic (3.79e-3)" "unprognostic (2.48e-2)" "unprognostic (1.22e-1)" "unprognostic (1.79e-2)" "unprognostic (3.21e-3)" "unprognostic (3.73e-1)" "prognostic unfavorable (5.19e-4)" "unprognostic (1.07e-1)" "unprognostic (3.06e-1)" "unprognostic (2.08e-1)" "unprognostic (3.80e-1)" 12.7 5.6 1.5 14.1 1.3 23.0 46.1 2.4 2.3 21.5 2.8 18.4 10.6 62.6 24.5 46.3 18.6 49.0 43.0 1.2 2.3 16.8 57.8 11.6 24.8 2.8 4.0 10.9 10.1 17.8 8.4 34.6 3.6 21.2 14.4 4.5 17.4 12.7 10.4 57.1 13.5 35.0 2.2 8.1 17.2 31.5 2.0 23.7 26.6 7.2 30.2 53.0 15.4 1.9 43.1 16.4 69.1 38.8 65.2 29.8 125.9 48.8 44.8 29.3 29.8 33.8 53.3 100.7 18.0 27.6 30.8 48.8 49.0 23.3 41.1 33.3 30.7 43.1 30.1 26.2 7.0 66.6 39.7 12.0 25.3 13.8 53.8 34.9 21.6 43.6 64.0 75.8 55.7 13.2 63.5 39.4 97.6 36.9 18.5 57.6 54.5 24.6 28.1 100.0 25.0 31.8 39.9 48.6 29.2 89.3 27.1 32.9 21.7 51.1 35.2 23.0 42.2 14.4 51.1 140.1 23.3 36.5 41.0 0.0 0.0 6.0 1.7 0.0 0.2 8.0 1.7 3.0 0.1 4.7 0.1 1.3 0.1 1.9 0.0 0.1 7.1 0.6 1.5 1.3 2.4 2.3 1.2 2.3 2.8 4.0 3.6 2.2 2.0 1.9 17.2 51.3 33.9 0.0 36.8 176.4 170.4 38.5 213.9 1.8 168.5 67.2 61.1 65.8 53.5 42.3 0.0 94.8 11.2 54.7 13.7 24.9 25.0 160.1 86.2 18.7 61.1 40.4 0.1 13.6 200.1 39.2 52.5 262.4 7.0 28.5 9.7 85.0 17.0 1.7 0.4 65.6 18.3 2.5 21.9 41.7 11.8 10.0 17.8 1.0 2.4 9.9 8.2 2.0 0.1 24.8 38.5 10.9 17.2 82.7 35.9 8.3 62.6 7.1 6.6 180.7 23.7 61.4 44.4 181.4 191.1 137.2 19.0 11.8 55.5 85.5 WEE2 "FLJ16107, WEE1B" ENSG00000214102 "WEE2 oocyte meiosis inhibiting kinase" P0C1S8 7 141708353-141731271 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Meiosis "Kinase, Transferase, Tyrosine-protein kinase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "Distal tubular cells: 1.9;Proximal tubular cells: 2.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 5 "CACO-2: 3.1" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA027418, HPA054280" Uncertain Enhanced Nucleoplasm,Cytosol NA NA "Cluster 39: CACO-2 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm Cytosol "HPA027418: AB_10603144, HPA054280: " "unprognostic (6.35e-2)" "unprognostic (1.47e-1)" "unprognostic (1.89e-1)" "unprognostic (3.18e-1)" "unprognostic (2.33e-1)" "unprognostic (4.00e-2)" "unprognostic (2.90e-1)" "unprognostic (1.97e-2)" "unprognostic (3.23e-2)" "unprognostic (3.02e-2)" "unprognostic (2.61e-1)" "unprognostic (1.76e-2)" "unprognostic (1.73e-1)" "unprognostic (3.25e-2)" "unprognostic (2.66e-1)" "unprognostic (6.07e-2)" "unprognostic (2.88e-3)" 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.2 0.0 0.3 0.2 0.4 0.3 0.0 0.0 0.3 0.0 0.1 0.4 0.1 0.1 0.3 0.3 0.0 0.1 0.0 0.1 0.1 0.0 0.2 0.2 0.0 0.2 0.6 0.1 0.0 0.2 0.1 0.2 0.3 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.5 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 3.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.5 0.0 0.0 0.0 0.1 0.4 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.6 0.4 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.6 0.4 0.2 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.1 0.2 0.1 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 2.3 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 WNK1 "HSAN2, HSN2, PPP1R167, PRKWNK1" ENSG00000060237 "WNK lysine deficient protein kinase 1" Q9H4A3 12 752579-911452 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Protein kinase inhibitor, Serine/threonine-protein kinase, Transferase" "Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 293.0" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 336.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046541, HPA059157" Enhanced Supported Cytosol NA NA 92000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 70: Brain - Nervous system development" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Cytosol "HPA046541: AB_2679690, HPA059157: AB_2683935" "unprognostic (1.40e-1)" "unprognostic (1.54e-2)" "unprognostic (4.82e-2)" "unprognostic (1.75e-1)" "unprognostic (1.27e-1)" "unprognostic (7.68e-2)" "unprognostic (1.05e-3)" "unprognostic (1.57e-1)" "unprognostic (1.24e-1)" "prognostic unfavorable (9.67e-4)" "unprognostic (1.84e-1)" "unprognostic (2.49e-1)" "unprognostic (4.38e-1)" "unprognostic (1.40e-1)" "unprognostic (1.32e-1)" "unprognostic (5.17e-2)" "unprognostic (1.30e-2)" 56.7 20.6 190.8 36.4 236.8 54.2 33.5 179.4 166.1 32.8 110.8 22.8 14.4 26.7 30.4 72.1 29.4 27.1 63.8 132.3 161.1 84.0 31.6 44.6 39.2 232.3 238.4 30.1 22.5 51.1 17.0 36.0 217.0 29.7 24.2 87.4 24.0 33.4 79.7 52.0 17.4 36.1 225.4 30.2 27.6 48.3 238.0 61.3 27.7 79.8 46.9 35.8 43.8 293.0 53.9 97.5 131.8 11.3 88.1 80.0 52.2 48.3 61.6 58.2 51.3 59.4 55.7 71.0 16.8 107.8 73.5 39.8 93.8 56.7 84.3 124.7 51.4 169.4 122.2 46.1 66.7 86.9 68.2 64.0 82.1 97.6 164.4 61.6 73.4 68.0 76.4 158.2 77.8 54.1 154.6 15.6 105.8 47.8 24.3 78.0 138.8 20.8 80.6 96.8 35.1 40.7 121.8 82.9 33.6 183.3 86.8 97.2 78.3 67.1 77.3 86.2 70.8 23.8 43.1 103.8 59.4 44.6 53.2 0.7 1.8 1.6 1.9 2.1 1.9 1.7 1.9 2.1 1.4 1.2 1.2 1.9 5.6 1.4 4.7 1.2 3.4 1.6 190.8 236.8 179.4 166.1 132.3 161.1 232.3 238.4 217.0 225.4 238.0 293.0 261.1 102.5 141.6 77.1 65.3 112.8 42.3 38.3 85.4 87.9 50.6 39.5 241.6 50.1 47.1 90.1 150.1 32.5 83.0 27.8 86.1 28.0 29.7 63.0 68.6 106.7 58.7 304.2 182.3 24.4 32.9 58.3 37.2 70.2 52.6 46.2 52.5 71.7 57.3 84.1 165.0 26.3 16.2 121.4 80.8 21.2 61.8 96.7 37.4 114.3 95.7 64.0 61.8 126.7 336.4 41.7 34.8 55.7 76.5 59.0 24.2 21.8 64.6 96.1 13.1 69.6 63.8 186.5 74.6 147.2 136.0 28.5 112.9 33.2 25.8 55.2 WNK2 "KIAA1760, NY-CO-43, PRKWNK2, SDCCAG43" ENSG00000165238 "WNK lysine deficient protein kinase 2" Q9Y3S1 9 93184916-93320572 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 83.1;skeletal muscle: 62.3" "Cell type enhanced" "Detected in many" "Astrocytes: 76.4;Cone photoreceptor cells: 160.6;Excitatory neurons: 128.5;Inhibitory neurons: 98.8;Intestinal goblet cells: 77.3;Rod photoreceptor cells: 106.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "Daudi: 18.8;Hep G2: 31.0;SCLC-21H: 37.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015555, HPA016519, CAB017813" Enhanced Approved Cytosol NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 38: Heart - Muscle contraction" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "CAB017813: , HPA015555: AB_2669218, HPA016519: AB_2669380" "unprognostic (5.02e-2)" "unprognostic (1.32e-2)" "unprognostic (2.61e-1)" "unprognostic (1.95e-1)" "unprognostic (2.28e-1)" "unprognostic (1.01e-1)" "unprognostic (2.04e-1)" "unprognostic (1.79e-3)" "unprognostic (1.94e-1)" "unprognostic (2.81e-2)" "unprognostic (1.31e-3)" "unprognostic (2.23e-1)" "unprognostic (4.48e-3)" "unprognostic (6.51e-2)" "unprognostic (1.44e-1)" "unprognostic (4.38e-4)" "unprognostic (1.62e-1)" 2.0 3.0 14.9 3.3 14.8 0.0 4.9 4.6 39.1 4.7 0.3 36.0 17.9 5.8 4.2 5.7 15.4 1.3 83.1 18.3 7.7 0.8 1.3 0.9 0.5 13.8 6.0 1.1 42.8 2.3 29.6 3.0 8.8 16.7 11.9 28.8 47.3 12.3 62.3 15.8 21.5 4.5 1.9 2.7 14.7 6.6 14.2 7.1 1.8 31.0 1.0 5.5 3.4 10.5 7.4 6.6 4.6 13.2 0.0 0.0 8.8 0.0 0.0 0.1 0.0 2.7 0.2 18.8 2.4 0.0 1.3 0.3 10.4 0.0 0.0 0.0 12.1 0.0 5.8 31.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 2.3 12.2 0.0 0.0 9.8 0.2 0.2 11.5 7.2 0.4 0.0 0.0 15.3 0.0 1.1 37.6 14.8 2.4 10.2 0.9 1.3 1.3 2.2 0.1 0.0 4.8 0.2 0.0 0.0 0.0 9.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 14.9 14.8 4.6 39.1 18.3 7.7 13.8 6.0 8.8 1.9 14.2 10.5 0.3 0.0 0.0 76.4 0.3 1.3 8.5 3.1 0.0 62.0 19.4 18.7 58.1 31.5 14.1 0.0 160.6 15.5 0.2 34.3 0.0 17.1 1.2 7.7 9.2 1.3 32.4 0.0 128.5 9.1 6.7 2.7 3.6 15.8 0.0 8.6 0.4 0.2 3.4 1.7 98.8 77.3 6.1 1.3 2.2 2.6 0.9 0.1 1.8 29.0 0.6 60.3 0.0 9.0 3.2 3.2 57.0 6.0 0.2 11.1 47.7 1.1 6.6 106.8 13.1 3.5 5.0 0.7 7.7 1.1 5.5 15.6 0.4 0.1 59.0 8.9 WNK3 PRKWNK3 ENSG00000196632 "WNK lysine deficient protein kinase 3" Q9BYP7 X 54192823-54358642 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "epididymis: 11.7;testis: 9.9" "Group enriched" "Detected in many" 4 "Cardiomyocytes: 193.3;Granulosa cells: 199.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 4.5;AN3-CA: 3.4;HAP1: 5.2;NTERA-2: 9.1;SiHa: 4.5;SuSa: 3.8;U-2 OS: 3.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA077678 Approved Approved Vesicles NA NA "Cluster 32: T-cells - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 40: Granulosa cells - Unknown function" Vesicles "HPA077678: AB_2686850" "unprognostic (1.86e-1)" "unprognostic (1.68e-3)" "unprognostic (2.44e-1)" "unprognostic (7.87e-5)" "unprognostic (4.82e-3)" "unprognostic (1.85e-3)" "unprognostic (1.85e-2)" "unprognostic (3.32e-2)" "unprognostic (3.38e-1)" "unprognostic (3.03e-2)" "unprognostic (5.78e-4)" "unprognostic (2.22e-1)" "unprognostic (2.64e-2)" "unprognostic (5.61e-2)" "unprognostic (9.99e-2)" "unprognostic (7.63e-2)" "unprognostic (8.74e-2)" 0.2 2.5 1.6 0.1 1.7 0.1 0.6 0.3 1.9 0.6 0.0 0.3 0.2 0.5 11.7 0.2 0.8 0.3 0.7 1.0 4.6 1.0 3.6 0.3 0.1 1.6 4.8 3.0 0.3 0.9 2.4 0.3 2.4 0.9 0.0 3.3 0.3 0.8 0.1 0.3 0.2 0.5 0.6 0.2 0.6 9.9 4.5 0.1 0.6 0.1 0.1 0.5 0.4 1.2 0.0 0.0 4.5 3.4 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 1.8 0.0 5.2 0.1 0.2 0.0 0.9 0.0 0.0 0.1 0.1 0.0 0.1 0.3 0.0 0.1 0.0 0.8 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 9.1 0.0 0.0 2.2 0.6 0.0 0.9 0.1 1.4 1.3 4.5 0.0 0.5 3.8 0.4 0.0 0.2 0.0 3.9 0.0 1.0 0.0 3.3 0.0 1.2 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 1.7 0.3 1.9 1.0 4.6 1.6 4.8 2.4 0.6 4.5 1.2 1.9 0.0 2.3 18.3 0.7 3.7 4.3 0.3 9.1 24.9 5.8 6.9 193.3 2.8 3.2 7.3 14.6 0.2 0.0 0.1 5.9 1.7 6.4 2.0 7.8 8.5 0.0 0.8 14.5 0.0 0.3 6.7 0.0 4.9 6.3 199.5 20.3 48.3 0.1 35.3 29.7 0.0 2.0 0.8 1.5 20.4 15.8 0.6 0.0 3.7 0.0 19.5 0.0 48.2 19.2 0.2 0.0 43.6 0.0 6.0 0.0 3.9 0.2 43.3 6.6 4.8 10.5 43.8 46.3 2.1 1.1 0.1 1.5 9.8 0.0 1.4 WNK4 PRKWNK4 ENSG00000126562 "WNK lysine deficient protein kinase 4" Q96J92 17 42780610-42797066 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 11.0;kidney: 37.6;prostate: 11.6" "Cell type enriched" "Detected in some" 4 "Distal tubular cells: 160.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 32.6;K-562: 36.8;TIME: 34.1;WM-115: 23.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA016500 Approved NA NA "Cluster 7: Kidney - Transmembrane transport" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 39: Non-specific - Basic cellular processes" "HPA016500: AB_10962984" "unprognostic (6.34e-3)" "unprognostic (1.35e-1)" "unprognostic (2.15e-1)" "unprognostic (5.58e-2)" "unprognostic (1.78e-2)" "unprognostic (1.96e-1)" "unprognostic (2.48e-1)" "unprognostic (1.69e-1)" "unprognostic (5.84e-2)" "unprognostic (3.94e-1)" "unprognostic (2.08e-3)" "unprognostic (4.33e-3)" "unprognostic (7.70e-3)" "unprognostic (1.62e-1)" "unprognostic (6.11e-2)" "unprognostic (1.43e-1)" "unprognostic (7.99e-2)" 1.3 0.0 0.7 1.1 0.9 0.0 2.8 0.8 3.3 0.6 0.3 9.8 1.9 0.2 0.7 8.9 0.4 0.0 0.1 1.7 1.1 37.6 0.2 0.1 0.1 1.1 0.7 4.3 0.2 0.0 1.2 0.0 0.7 11.6 11.0 0.6 1.8 1.1 0.0 0.5 3.7 0.4 0.6 0.1 3.4 0.2 1.0 0.0 0.0 0.3 0.1 0.2 0.4 1.0 2.1 1.2 0.6 0.0 0.7 0.2 4.8 11.9 4.8 4.5 1.3 0.7 1.0 0.6 6.8 32.6 1.2 0.0 0.2 0.3 8.6 0.6 1.8 0.1 0.0 4.7 7.4 0.3 0.7 3.9 1.4 6.4 2.1 2.1 0.3 0.4 36.8 1.3 0.0 1.0 0.0 1.1 0.3 2.0 8.2 0.6 1.2 0.0 0.0 0.5 0.0 0.2 0.1 0.2 1.7 4.1 2.4 2.7 34.1 0.3 3.1 0.5 0.4 6.2 5.3 1.2 0.0 2.1 23.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.9 0.8 3.3 1.7 1.1 1.1 0.7 0.7 0.6 1.0 1.0 0.2 0.0 0.6 0.0 0.5 0.0 0.2 0.0 0.6 0.2 7.1 4.1 1.0 1.5 0.6 7.3 0.0 0.0 0.3 8.0 160.4 0.0 0.0 5.1 1.1 0.2 13.1 0.0 0.2 0.2 0.2 0.1 3.1 6.7 4.5 0.1 0.7 0.0 0.0 0.0 0.2 40.1 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 3.2 0.4 0.0 3.6 0.9 1.0 2.9 0.5 0.0 0.2 0.5 0.8 0.8 12.1 0.4 0.0 0.2 0.0 13.1 0.3 WWP1 "AIP5, DKFZP434D2111" ENSG00000123124 "WW domain containing E3 ubiquitin protein ligase 1" Q9H0M0 8 86342547-86478420 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Host-virus interaction, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 171.4" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA023180 Approved Approved "Golgi apparatus,Plasma membrane,Cytosol" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "Golgi apparatus, Plasma membrane" "HPA023180: AB_10602587" "unprognostic (3.89e-1)" "unprognostic (6.63e-2)" "unprognostic (3.81e-2)" "unprognostic (7.91e-2)" "unprognostic (3.70e-1)" "unprognostic (1.02e-1)" "unprognostic (1.93e-1)" "unprognostic (4.24e-2)" "unprognostic (1.83e-1)" "unprognostic (9.43e-3)" "unprognostic (3.09e-3)" "unprognostic (1.48e-1)" "prognostic favorable (5.45e-5)" "unprognostic (2.35e-1)" "unprognostic (4.63e-1)" "unprognostic (3.19e-3)" "unprognostic (1.01e-1)" 33.6 22.1 16.3 25.8 21.5 18.2 40.6 19.6 16.3 23.6 24.3 26.9 26.3 23.0 24.6 33.1 18.5 45.3 50.8 14.3 20.7 40.9 111.7 27.2 39.0 18.3 19.0 24.7 28.0 116.3 9.8 36.9 19.7 33.4 33.1 43.2 25.9 25.6 171.4 40.8 28.1 24.6 18.1 45.7 34.3 29.5 19.5 22.7 32.6 122.2 30.6 33.7 15.8 23.1 59.8 27.1 18.3 13.1 23.0 22.4 16.3 21.0 22.5 16.5 19.5 18.9 35.3 24.9 14.0 36.5 22.9 49.3 26.4 34.1 28.5 31.6 21.0 28.7 24.4 44.7 16.8 11.7 14.0 20.5 42.5 18.2 33.3 25.3 74.1 29.0 14.3 28.7 28.4 29.6 27.7 8.1 11.2 82.6 30.0 18.0 21.4 22.5 37.3 44.5 5.5 12.9 21.2 104.7 23.0 39.8 31.3 10.8 84.4 23.9 28.7 26.3 10.7 33.9 22.0 25.7 29.9 1.6 19.0 6.2 2.1 3.9 5.2 1.9 4.6 2.7 6.4 5.3 1.5 2.4 7.5 4.7 1.3 2.4 2.2 1.9 6.5 2.0 16.3 21.5 19.6 16.3 14.3 20.7 18.3 19.0 19.7 18.1 19.5 23.1 51.2 25.6 22.6 29.0 13.0 35.8 26.9 15.4 26.7 28.8 41.7 23.5 82.7 44.3 19.2 29.5 58.4 28.3 19.5 23.7 43.0 20.5 42.1 22.6 20.1 32.3 23.6 3.0 55.3 37.6 3.3 27.6 35.2 35.5 3.8 18.0 62.4 88.8 55.9 40.4 134.6 25.3 14.2 95.2 28.1 12.7 32.3 43.0 30.2 61.8 18.6 23.3 18.6 60.3 103.8 45.1 16.0 36.5 18.5 45.1 15.8 45.7 17.2 52.6 6.6 18.8 16.6 12.4 21.2 28.8 39.5 23.0 32.0 25.1 19.7 38.3 WWP2 AIP2 ENSG00000198373 "WW domain containing E3 ubiquitin protein ligase 2" O00308 16 69762328-69941741 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocyte precursor cells: 79.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 18: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 68: Oligodendrocytes - Mixed function" "unprognostic (1.63e-1)" "unprognostic (3.72e-2)" "unprognostic (1.93e-1)" "unprognostic (1.09e-3)" "unprognostic (2.86e-1)" "unprognostic (1.73e-1)" "unprognostic (1.14e-2)" "unprognostic (5.22e-2)" "unprognostic (1.14e-1)" "unprognostic (7.50e-2)" "unprognostic (2.08e-2)" "unprognostic (9.81e-2)" "prognostic favorable (5.87e-11)" "unprognostic (4.26e-2)" "unprognostic (4.10e-2)" "unprognostic (1.08e-1)" "unprognostic (1.62e-1)" 27.3 31.2 22.4 18.2 23.5 34.1 22.8 19.7 22.3 23.5 23.8 23.2 23.4 22.6 10.1 26.2 23.5 15.1 16.7 20.0 20.9 31.7 18.4 23.4 22.0 22.9 21.5 23.4 29.6 25.9 17.7 16.2 22.2 20.5 19.8 15.5 31.9 17.2 21.6 30.7 23.5 14.3 19.7 30.2 26.3 16.1 22.0 19.7 22.6 9.3 19.3 18.8 20.9 26.6 25.0 24.8 15.7 16.3 12.9 10.7 24.1 16.3 18.6 27.4 28.3 23.1 18.5 28.4 17.4 29.2 14.9 28.6 20.8 24.7 20.4 13.4 17.9 15.9 15.1 39.4 24.1 28.3 22.4 15.7 17.9 37.4 25.9 15.4 25.6 24.1 24.5 15.5 17.6 43.2 15.5 30.9 22.1 20.6 10.5 34.6 13.1 49.5 26.6 23.6 19.3 21.3 69.1 19.8 15.4 10.2 30.9 34.6 25.6 21.3 30.8 29.9 19.8 36.3 26.0 42.7 22.9 23.6 38.2 35.9 19.0 29.8 16.3 23.5 12.2 10.8 12.1 13.0 14.9 12.4 12.3 8.7 49.7 8.5 30.8 7.0 11.7 17.1 22.4 23.5 19.7 22.3 20.0 20.9 22.9 21.5 22.2 19.7 22.0 26.6 11.9 9.6 31.0 16.0 18.7 7.4 7.0 5.4 9.1 9.0 10.0 8.3 8.7 21.5 12.8 14.7 10.4 10.0 13.1 47.2 1.9 12.3 22.6 13.9 7.5 13.1 16.8 13.9 20.3 20.0 9.2 8.2 31.1 14.4 21.5 12.7 13.2 13.3 12.8 10.1 26.0 16.1 6.1 22.7 13.6 38.5 10.2 18.8 10.6 42.2 18.8 12.3 19.6 79.4 56.4 16.8 23.6 8.6 12.4 6.1 22.6 10.0 24.1 6.5 13.1 6.9 17.7 8.1 6.0 9.6 6.0 20.0 14.6 7.0 20.4 9.9 ZC3HAV1 "ARTD13, FLB6421, FLJ13288, MGC48898, PARP13, ZAP, ZC3H2, ZC3HDC2" ENSG00000105939 "Zinc finger CCCH-type containing, antiviral 1" Q7Z2W4 7 139043515-139132122 "Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Antiviral defense, Immunity, Innate immunity" RNA-binding "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 85.9" "Cell type enhanced" "Detected in many" "dendritic cells: 194.8;Glandular and luminal cells: 359.9;T-cells: 222.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA047818, HPA059096" Approved Supported "Golgi apparatus,Cytosol" NA NA 24000 "Cluster 49: Eosinophils - Unknown function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 24: NB-4 - Immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Cytosol "Golgi apparatus" "HPA047818: AB_10962642, HPA059096: AB_2683903" "unprognostic (1.68e-1)" "unprognostic (1.99e-2)" "unprognostic (1.07e-1)" "unprognostic (1.51e-2)" "unprognostic (3.92e-1)" "unprognostic (2.61e-2)" "prognostic unfavorable (8.77e-7)" "unprognostic (5.40e-2)" "unprognostic (3.08e-1)" "unprognostic (2.55e-2)" "unprognostic (3.72e-1)" "unprognostic (5.41e-2)" "unprognostic (3.31e-3)" "prognostic favorable (6.86e-4)" "unprognostic (6.47e-2)" "unprognostic (1.99e-1)" "unprognostic (7.84e-2)" 13.5 12.7 8.7 19.1 8.9 85.9 11.1 8.1 15.2 8.6 12.2 12.9 9.7 8.6 10.3 12.9 9.7 11.4 6.4 8.1 13.6 11.1 11.0 16.1 24.0 12.3 11.5 10.9 7.3 9.2 6.2 9.3 12.3 9.5 13.7 2.5 14.3 9.1 3.2 13.1 13.9 13.8 12.7 21.0 10.4 6.5 14.9 24.0 10.6 5.6 23.8 11.9 8.7 12.4 25.1 29.5 4.1 24.7 37.4 35.9 17.6 27.5 21.2 46.9 47.7 21.6 31.4 21.9 25.2 43.9 40.6 27.6 33.2 32.6 26.3 37.2 12.2 43.8 29.7 26.9 21.8 51.1 38.6 37.0 20.3 53.3 11.8 17.4 35.3 32.1 37.6 23.5 20.1 23.3 41.9 59.0 16.6 18.6 17.6 48.5 14.6 21.0 32.0 31.0 7.5 15.4 43.1 29.2 37.8 9.3 17.4 30.9 45.3 9.9 14.3 27.6 23.1 17.9 20.2 49.9 22.4 47.0 24.0 78.7 19.6 30.8 43.0 26.0 56.0 32.2 61.9 53.1 15.2 35.3 59.0 58.6 52.5 38.7 30.6 17.7 58.8 30.6 8.7 8.9 8.1 15.2 8.1 13.6 12.3 11.5 12.3 12.7 14.9 12.4 150.3 25.6 41.1 8.1 119.4 28.7 21.7 17.5 62.6 2.8 70.8 44.8 6.2 21.5 21.1 53.3 4.2 12.6 194.8 57.0 9.8 20.2 2.8 185.9 77.7 74.5 53.2 64.4 0.8 21.2 23.1 68.1 60.6 359.9 32.3 41.6 49.2 36.1 35.1 0.0 3.0 42.2 8.2 43.9 150.0 1.9 18.6 84.4 39.2 33.7 57.1 13.9 88.6 27.6 1.0 23.8 33.8 26.7 104.2 41.5 28.0 36.4 29.9 1.3 13.1 79.5 53.6 1.0 1.1 61.7 22.3 2.3 222.3 41.3 35.8 28.0 ZNRF1 "DKFZp434E229, FLJ14846, nin283" ENSG00000186187 "Zinc and ring finger 1" Q8ND25 16 74999024-75110994 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "basophil: 2.4;T-reg: 2.4" "Group enriched" "Detected in many" 4 "granulocytes: 2.4;T-cells: 2.4" "Cell line enhanced" "Detected in all" "HMC-1: 176.9;MOLT-4: 134.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027470 Approved NA NA "Cluster 10: Basophils - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 3: HMC-1 - Innate immune response" "Cluster 44: Endometrium - Transcription" "HPA027470: AB_10603108" "unprognostic (2.78e-2)" "prognostic favorable (9.90e-4)" "unprognostic (4.45e-3)" "unprognostic (1.51e-1)" "unprognostic (4.34e-2)" "unprognostic (1.18e-2)" "unprognostic (2.51e-1)" "unprognostic (2.07e-1)" "unprognostic (1.12e-2)" "unprognostic (5.38e-2)" "unprognostic (3.69e-1)" "unprognostic (2.28e-1)" "unprognostic (1.46e-1)" "unprognostic (4.89e-2)" "unprognostic (2.87e-1)" "unprognostic (2.10e-2)" "unprognostic (1.44e-2)" 18.7 16.5 21.1 9.6 22.3 6.7 17.8 9.1 22.8 25.3 19.0 30.6 9.6 22.5 9.5 65.9 18.0 7.5 21.0 23.4 24.5 14.7 17.6 24.1 7.7 19.6 22.5 17.4 11.5 11.8 13.4 11.2 18.6 13.7 12.1 7.4 16.9 7.0 81.2 25.0 15.3 11.4 13.4 4.5 21.0 37.4 30.7 53.2 29.3 30.6 13.3 22.5 26.4 17.5 10.9 15.7 26.7 27.5 27.7 21.4 91.2 13.0 18.3 17.5 17.1 25.4 33.2 2.9 9.9 28.3 16.8 25.5 13.0 17.8 13.9 26.7 7.5 56.7 4.8 47.0 22.0 27.5 176.9 19.5 14.7 18.4 14.9 30.8 29.0 68.3 27.8 8.8 13.7 104.5 134.6 100.6 37.1 31.4 16.7 59.0 10.0 17.4 25.1 30.5 35.4 37.7 20.7 27.0 8.3 21.7 71.6 25.8 19.9 12.0 21.0 21.5 7.9 50.5 55.1 31.6 15.8 30.2 12.6 2.4 0.5 0.4 0.0 0.5 0.5 0.0 0.6 0.0 0.3 0.0 0.0 0.1 0.5 0.0 0.5 0.0 2.4 0.1 21.1 22.3 9.1 22.8 23.4 24.5 19.6 22.5 18.6 13.4 30.7 17.5 34.8 9.6 14.4 16.6 1.8 15.9 16.0 11.2 4.6 12.6 24.3 22.4 16.4 18.6 14.0 3.7 52.1 6.4 2.3 25.5 0.0 8.9 25.9 30.7 15.1 30.2 19.8 30.5 45.2 12.7 10.1 15.1 18.3 28.0 36.8 23.7 12.8 14.4 10.4 3.3 42.4 14.0 14.2 7.3 10.9 16.3 6.8 7.3 14.2 33.7 7.6 15.0 0.0 33.7 29.5 20.0 12.1 4.1 1.8 17.2 9.6 6.2 15.1 6.5 0.0 12.4 14.7 13.6 18.7 21.0 19.6 4.5 13.3 16.7 12.7 29.6 ZNRF2 RNF202 ENSG00000180233 "Zinc and ring finger 2" Q8NHG8 7 30284597-30367689 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Microglial cells: 119.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "plasmacytoid DC: 2.2" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA072244 Approved Uncertain "Nucleoplasm,Nucleoli fibrillar center,Vesicles" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 25: RPMI-8226 - Immune response" "Cluster 24: Non-specific - Transcription regulation" "Nucleoplasm, Vesicles" "Nucleoli fibrillar center" "HPA072244: AB_2732197" "unprognostic (9.44e-2)" "unprognostic (2.38e-2)" "unprognostic (8.64e-2)" "prognostic unfavorable (7.68e-4)" "unprognostic (4.46e-2)" "unprognostic (1.24e-1)" "unprognostic (3.06e-1)" "unprognostic (6.10e-2)" "unprognostic (1.26e-1)" "unprognostic (1.67e-1)" "unprognostic (1.71e-1)" "unprognostic (5.93e-2)" "prognostic favorable (2.29e-4)" "unprognostic (1.51e-1)" "unprognostic (2.71e-1)" "prognostic favorable (8.71e-4)" "unprognostic (8.67e-2)" 7.4 6.5 4.8 11.5 5.3 13.0 9.6 5.5 4.2 5.1 14.5 18.9 13.2 8.4 10.7 10.4 4.4 9.4 5.1 4.3 4.0 22.0 21.5 7.4 15.3 7.4 6.6 3.7 10.3 9.1 5.0 9.3 6.0 5.7 16.2 4.7 9.2 5.3 5.7 10.0 15.2 9.5 7.5 10.8 15.0 24.0 7.9 8.9 11.7 6.2 13.2 11.2 4.2 8.4 13.2 4.7 3.8 3.4 4.4 3.0 19.8 4.9 5.1 5.4 7.2 2.4 21.5 13.8 12.6 4.1 14.0 12.5 12.7 8.5 5.7 13.4 11.5 8.6 9.7 6.4 2.3 6.7 15.6 4.6 14.0 3.7 9.1 5.6 4.6 10.5 10.7 26.6 5.9 5.1 13.6 17.5 8.9 13.2 5.9 11.7 8.2 23.8 16.4 28.0 13.0 12.3 9.9 41.2 8.5 22.2 11.1 26.5 5.1 5.2 8.9 5.0 10.5 44.9 41.5 18.1 5.7 14.3 7.8 0.2 0.3 0.4 0.3 0.3 0.5 0.4 0.4 0.5 0.3 0.2 0.2 0.4 0.5 0.3 0.4 2.2 1.0 0.2 4.8 5.3 5.5 4.2 4.3 4.0 7.4 6.6 6.0 7.5 7.9 8.4 11.3 9.6 8.4 19.9 13.9 15.9 7.4 4.8 8.6 11.3 26.5 10.4 3.6 14.3 5.0 16.5 41.7 10.1 40.8 60.0 7.9 4.9 5.2 32.7 7.6 6.6 31.3 6.1 54.4 10.3 11.4 5.1 14.3 43.7 3.8 4.7 8.2 41.6 10.7 1.7 32.3 14.0 0.0 23.3 16.2 10.1 2.8 23.1 12.4 119.9 13.1 5.1 4.1 41.7 39.7 7.4 19.5 2.2 11.5 8.5 22.6 32.3 5.8 5.8 6.6 7.7 9.8 18.3 7.0 7.9 18.9 11.5 17.6 7.6 23.4 14.3 ZSWIM2 "MEX, MGC33890, ZZZ2" ENSG00000163012 "Zinc finger SWIM-type containing 2" Q8NEG5 2 186827475-186849208 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 13 "testis: 9.3" "Cell type enhanced" "Detected in some" "Early spermatids: 61.1;Late spermatids: 18.6;Spermatocytes: 11.5" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 23: Spermatids - Flagellum & Golgi organization" "unprognostic (2.00e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.1 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 61.1 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.0 0.0 0.0 0.0 18.6 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.5 0.8 0.0 0.0 0.3 0.0 0.0 0.0 0.0