Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific nTPM" "RNA single cell type specificity" "RNA single cell type distribution" "RNA single cell type specificity score" "RNA single cell type specific nTPM" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific nTPM" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific nTPM" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific nTPM" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific nTPM" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific nTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific nTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "CCD Protein" "CCD Transcript" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Blood expression cluster" "Tissue expression cluster" "Cell line expression cluster" "Single cell expression cluster" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [nTPM]" "Tissue RNA - adrenal gland [nTPM]" "Tissue RNA - amygdala [nTPM]" "Tissue RNA - appendix [nTPM]" "Tissue RNA - basal ganglia [nTPM]" "Tissue RNA - bone marrow [nTPM]" "Tissue RNA - breast [nTPM]" "Tissue RNA - cerebellum [nTPM]" "Tissue RNA - cerebral cortex [nTPM]" "Tissue RNA - cervix [nTPM]" "Tissue RNA - choroid plexus [nTPM]" "Tissue RNA - colon [nTPM]" "Tissue RNA - duodenum [nTPM]" "Tissue RNA - endometrium 1 [nTPM]" "Tissue RNA - epididymis [nTPM]" "Tissue RNA - esophagus [nTPM]" "Tissue RNA - fallopian tube [nTPM]" "Tissue RNA - gallbladder [nTPM]" "Tissue RNA - heart muscle [nTPM]" "Tissue RNA - hippocampal formation [nTPM]" "Tissue RNA - hypothalamus [nTPM]" "Tissue RNA - kidney [nTPM]" "Tissue RNA - liver [nTPM]" "Tissue RNA - lung [nTPM]" "Tissue RNA - lymph node [nTPM]" "Tissue RNA - medulla oblongata [nTPM]" "Tissue RNA - midbrain [nTPM]" "Tissue RNA - ovary [nTPM]" "Tissue RNA - pancreas [nTPM]" "Tissue RNA - parathyroid gland [nTPM]" "Tissue RNA - pituitary gland [nTPM]" "Tissue RNA - placenta [nTPM]" "Tissue RNA - pons [nTPM]" "Tissue RNA - prostate [nTPM]" "Tissue RNA - rectum [nTPM]" "Tissue RNA - retina [nTPM]" "Tissue RNA - salivary gland [nTPM]" "Tissue RNA - seminal vesicle [nTPM]" "Tissue RNA - skeletal muscle [nTPM]" "Tissue RNA - skin 1 [nTPM]" "Tissue RNA - small intestine [nTPM]" "Tissue RNA - smooth muscle [nTPM]" "Tissue RNA - spinal cord [nTPM]" "Tissue RNA - spleen [nTPM]" "Tissue RNA - stomach 1 [nTPM]" "Tissue RNA - testis [nTPM]" "Tissue RNA - thalamus [nTPM]" "Tissue RNA - thymus [nTPM]" "Tissue RNA - thyroid gland [nTPM]" "Tissue RNA - tongue [nTPM]" "Tissue RNA - tonsil [nTPM]" "Tissue RNA - urinary bladder [nTPM]" "Tissue RNA - vagina [nTPM]" "Tissue RNA - white matter [nTPM]" "Cell RNA - A-431 [nTPM]" "Cell RNA - A549 [nTPM]" "Cell RNA - AF22 [nTPM]" "Cell RNA - AN3-CA [nTPM]" "Cell RNA - ASC diff [nTPM]" "Cell RNA - ASC TERT1 [nTPM]" "Cell RNA - BEWO [nTPM]" "Cell RNA - BJ [nTPM]" "Cell RNA - BJ hTERT+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]" "Cell RNA - CACO-2 [nTPM]" "Cell RNA - CAPAN-2 [nTPM]" "Cell RNA - Daudi [nTPM]" "Cell RNA - EFO-21 [nTPM]" "Cell RNA - fHDF/TERT166 [nTPM]" "Cell RNA - GAMG [nTPM]" "Cell RNA - HaCaT [nTPM]" "Cell RNA - HAP1 [nTPM]" "Cell RNA - HBEC3-KT [nTPM]" "Cell RNA - HBF TERT88 [nTPM]" "Cell RNA - HDLM-2 [nTPM]" "Cell RNA - HEK 293 [nTPM]" "Cell RNA - HEL [nTPM]" "Cell RNA - HeLa [nTPM]" "Cell RNA - Hep G2 [nTPM]" "Cell RNA - HHSteC [nTPM]" "Cell RNA - HL-60 [nTPM]" "Cell RNA - HMC-1 [nTPM]" "Cell RNA - HSkMC [nTPM]" "Cell RNA - hTCEpi [nTPM]" "Cell RNA - hTEC/SVTERT24-B [nTPM]" "Cell RNA - hTERT-HME1 [nTPM]" "Cell RNA - hTERT-RPE1 [nTPM]" "Cell RNA - HUVEC TERT2 [nTPM]" "Cell RNA - JURKAT [nTPM]" "Cell RNA - K-562 [nTPM]" "Cell RNA - Karpas-707 [nTPM]" "Cell RNA - LHCN-M2 [nTPM]" "Cell RNA - MCF7 [nTPM]" "Cell RNA - MOLT-4 [nTPM]" "Cell RNA - NB-4 [nTPM]" "Cell RNA - NTERA-2 [nTPM]" "Cell RNA - OE19 [nTPM]" "Cell RNA - PC-3 [nTPM]" "Cell RNA - REH [nTPM]" "Cell RNA - RH-30 [nTPM]" "Cell RNA - RPMI-8226 [nTPM]" "Cell RNA - RPTEC TERT1 [nTPM]" "Cell RNA - RT4 [nTPM]" "Cell RNA - SCLC-21H [nTPM]" "Cell RNA - SH-SY5Y [nTPM]" "Cell RNA - SiHa [nTPM]" "Cell RNA - SK-BR-3 [nTPM]" "Cell RNA - SK-MEL-30 [nTPM]" "Cell RNA - SuSa [nTPM]" "Cell RNA - T-47d [nTPM]" "Cell RNA - THP-1 [nTPM]" "Cell RNA - TIME [nTPM]" "Cell RNA - U-138 MG [nTPM]" "Cell RNA - U-2 OS [nTPM]" "Cell RNA - U-2197 [nTPM]" "Cell RNA - U-251 MG [nTPM]" "Cell RNA - U-266/70 [nTPM]" "Cell RNA - U-266/84 [nTPM]" "Cell RNA - U-698 [nTPM]" "Cell RNA - U-87 MG [nTPM]" "Cell RNA - U-937 [nTPM]" "Cell RNA - WM-115 [nTPM]" "Blood RNA - basophil [nTPM]" "Blood RNA - classical monocyte [nTPM]" "Blood RNA - eosinophil [nTPM]" "Blood RNA - gdT-cell [nTPM]" "Blood RNA - intermediate monocyte [nTPM]" "Blood RNA - MAIT T-cell [nTPM]" "Blood RNA - memory B-cell [nTPM]" "Blood RNA - memory CD4 T-cell [nTPM]" "Blood RNA - memory CD8 T-cell [nTPM]" "Blood RNA - myeloid DC [nTPM]" "Blood RNA - naive B-cell [nTPM]" "Blood RNA - naive CD4 T-cell [nTPM]" "Blood RNA - naive CD8 T-cell [nTPM]" "Blood RNA - neutrophil [nTPM]" "Blood RNA - NK-cell [nTPM]" "Blood RNA - non-classical monocyte [nTPM]" "Blood RNA - plasmacytoid DC [nTPM]" "Blood RNA - T-reg [nTPM]" "Blood RNA - total PBMC [nTPM]" "Brain RNA - amygdala [nTPM]" "Brain RNA - basal ganglia [nTPM]" "Brain RNA - cerebellum [nTPM]" "Brain RNA - cerebral cortex [nTPM]" "Brain RNA - hippocampal formation [nTPM]" "Brain RNA - hypothalamus [nTPM]" "Brain RNA - medulla oblongata [nTPM]" "Brain RNA - midbrain [nTPM]" "Brain RNA - pons [nTPM]" "Brain RNA - spinal cord [nTPM]" "Brain RNA - thalamus [nTPM]" "Brain RNA - white matter [nTPM]" "Single Cell Type RNA - Adipocytes [nTPM]" "Single Cell Type RNA - Alveolar cells type 1 [nTPM]" "Single Cell Type RNA - Alveolar cells type 2 [nTPM]" "Single Cell Type RNA - Astrocytes [nTPM]" "Single Cell Type RNA - B-cells [nTPM]" "Single Cell Type RNA - Basal keratinocytes [nTPM]" "Single Cell Type RNA - Basal prostatic cells [nTPM]" "Single Cell Type RNA - Basal respiratory cells [nTPM]" "Single Cell Type RNA - Basal squamous epithelial cells [nTPM]" "Single Cell Type RNA - Bipolar cells [nTPM]" "Single Cell Type RNA - Breast glandular cells [nTPM]" "Single Cell Type RNA - Breast myoepithelial cells [nTPM]" "Single Cell Type RNA - Cardiomyocytes [nTPM]" "Single Cell Type RNA - Cholangiocytes [nTPM]" "Single Cell Type RNA - Club cells [nTPM]" "Single Cell Type RNA - Collecting duct cells [nTPM]" "Single Cell Type RNA - Cone photoreceptor cells [nTPM]" "Single Cell Type RNA - Cytotrophoblasts [nTPM]" "Single Cell Type RNA - dendritic cells [nTPM]" "Single Cell Type RNA - Distal enterocytes [nTPM]" "Single Cell Type RNA - Distal tubular cells [nTPM]" "Single Cell Type RNA - Ductal cells [nTPM]" "Single Cell Type RNA - Early spermatids [nTPM]" "Single Cell Type RNA - Endometrial ciliated cells [nTPM]" "Single Cell Type RNA - Endometrial stromal cells [nTPM]" "Single Cell Type RNA - Endothelial cells [nTPM]" "Single Cell Type RNA - Enteroendocrine cells [nTPM]" "Single Cell Type RNA - Erythroid cells [nTPM]" "Single Cell Type RNA - Excitatory neurons [nTPM]" "Single Cell Type RNA - Exocrine glandular cells [nTPM]" "Single Cell Type RNA - Extravillous trophoblasts [nTPM]" "Single Cell Type RNA - Fibroblasts [nTPM]" "Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]" "Single Cell Type RNA - Glandular and luminal cells [nTPM]" "Single Cell Type RNA - granulocytes [nTPM]" "Single Cell Type RNA - Granulosa cells [nTPM]" "Single Cell Type RNA - Hepatic stellate cells [nTPM]" "Single Cell Type RNA - Hepatocytes [nTPM]" "Single Cell Type RNA - Hofbauer cells [nTPM]" "Single Cell Type RNA - Horizontal cells [nTPM]" "Single Cell Type RNA - Inhibitory neurons [nTPM]" "Single Cell Type RNA - Intestinal goblet cells [nTPM]" "Single Cell Type RNA - Ionocytes [nTPM]" "Single Cell Type RNA - Kupffer cells [nTPM]" "Single Cell Type RNA - Langerhans cells [nTPM]" "Single Cell Type RNA - Late spermatids [nTPM]" "Single Cell Type RNA - Leydig cells [nTPM]" "Single Cell Type RNA - Macrophages [nTPM]" "Single Cell Type RNA - Melanocytes [nTPM]" "Single Cell Type RNA - Microglial cells [nTPM]" "Single Cell Type RNA - monocytes [nTPM]" "Single Cell Type RNA - Muller glia cells [nTPM]" "Single Cell Type RNA - NK-cells [nTPM]" "Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]" "Single Cell Type RNA - Oligodendrocytes [nTPM]" "Single Cell Type RNA - Pancreatic endocrine cells [nTPM]" "Single Cell Type RNA - Paneth cells [nTPM]" "Single Cell Type RNA - Peritubular cells [nTPM]" "Single Cell Type RNA - Plasma cells [nTPM]" "Single Cell Type RNA - Prostatic glandular cells [nTPM]" "Single Cell Type RNA - Proximal enterocytes [nTPM]" "Single Cell Type RNA - Proximal tubular cells [nTPM]" "Single Cell Type RNA - Respiratory ciliated cells [nTPM]" "Single Cell Type RNA - Rod photoreceptor cells [nTPM]" "Single Cell Type RNA - Sertoli cells [nTPM]" "Single Cell Type RNA - Skeletal myocytes [nTPM]" "Single Cell Type RNA - Smooth muscle cells [nTPM]" "Single Cell Type RNA - Spermatocytes [nTPM]" "Single Cell Type RNA - Spermatogonia [nTPM]" "Single Cell Type RNA - Squamous epithelial cells [nTPM]" "Single Cell Type RNA - Suprabasal keratinocytes [nTPM]" "Single Cell Type RNA - Syncytiotrophoblasts [nTPM]" "Single Cell Type RNA - T-cells [nTPM]" "Single Cell Type RNA - Theca cells [nTPM]" "Single Cell Type RNA - Undifferentiated cells [nTPM]" "Single Cell Type RNA - Urothelial cells [nTPM]" ABTB2 "ABTB2A, BTBD22, DKFZP586C1619" ENSG00000166016 "Ankyrin repeat and BTB domain containing 2" Q8N961 11 34150987-34358010 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 24.1" "Cell type enhanced" "Detected in many" "Oligodendrocyte precursor cells: 50.3;Oligodendrocytes: 126.2;Syncytiotrophoblasts: 28.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 13 "eosinophil: 5.0;plasmacytoid DC: 1.6" "Group enriched" "Detected in many" 14 "dendritic cells: 1.6;granulocytes: 5.0" "Cell line enhanced" "Detected in many" "SK-BR-3: 24.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020065, HPA030699" Approved Supported Nucleoplasm,Vesicles NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 70: Brain - Nervous system development" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm Vesicles "HPA020065: AB_1844459, HPA030699: AB_2673576" "unprognostic (3.00e-1)" "prognostic unfavorable (5.70e-5)" "unprognostic (2.61e-1)" "unprognostic (9.09e-2)" "unprognostic (3.17e-2)" "unprognostic (2.40e-2)" "unprognostic (1.34e-1)" "unprognostic (1.23e-2)" "unprognostic (2.04e-1)" "unprognostic (2.09e-1)" "unprognostic (1.24e-3)" "unprognostic (2.86e-1)" "prognostic favorable (3.51e-5)" "unprognostic (1.50e-1)" "unprognostic (1.42e-1)" "unprognostic (3.81e-2)" "unprognostic (6.58e-2)" 2.3 13.0 7.9 2.0 12.6 2.5 2.0 18.1 6.7 8.1 1.2 3.4 8.8 6.1 4.4 4.1 4.6 2.1 12.8 5.3 8.5 9.4 11.6 2.9 2.1 24.1 16.3 2.5 2.3 0.5 3.5 3.2 16.7 4.9 2.5 2.6 6.7 4.3 16.9 6.8 7.0 2.5 12.7 0.9 2.5 2.7 15.9 2.4 2.0 7.2 2.0 3.6 5.6 20.3 5.6 16.2 6.4 1.8 1.7 0.1 6.4 3.2 2.5 2.8 5.3 4.0 4.0 0.2 5.3 4.1 16.5 10.5 3.6 3.7 2.3 0.2 8.8 0.1 9.8 17.4 1.0 8.9 1.2 0.9 2.0 5.6 2.4 10.1 0.0 0.7 1.9 0.5 1.8 13.8 0.3 10.7 8.0 8.1 8.8 1.7 3.8 6.3 10.0 13.0 8.1 6.6 8.1 24.6 6.5 4.2 5.3 3.8 0.9 3.1 0.5 9.8 5.8 0.9 0.4 0.1 7.1 2.5 9.7 0.0 0.1 5.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 1.6 0.0 0.0 7.9 12.6 18.1 6.7 5.3 8.5 24.1 16.3 16.7 12.7 15.9 20.3 0.7 0.0 2.3 18.9 1.1 4.7 3.2 1.3 1.2 2.1 3.0 3.3 10.0 2.8 1.1 12.9 0.0 2.7 2.5 12.2 5.9 4.6 1.2 3.4 4.5 0.9 7.2 0.0 4.0 4.5 1.1 5.8 4.6 10.7 1.3 0.3 0.0 6.8 0.8 0.0 8.9 2.3 4.1 0.8 6.1 0.3 1.2 1.2 1.8 6.5 9.3 7.5 0.0 50.3 126.2 10.5 9.1 6.0 2.1 9.3 15.5 2.0 0.3 0.6 0.0 4.3 2.4 0.5 1.1 1.0 4.8 28.3 2.9 0.4 2.9 7.5 ACE "ACE1, CD143, DCP1" ENSG00000159640 "Angiotensin I converting enzyme" P12821 17 63477061-63498380 "Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 265.1;testis: 101.9" "Group enriched" "Detected in many" 20 "Early spermatids: 543.6;Late spermatids: 1322.9;Proximal enterocytes: 1172.8" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "basal ganglia: 8.1" "Immune cell enhanced" "Detected in single" "memory B-cell: 1.0" "Low lineage specificity" "Detected in single" "Group enriched" "Detected in many" 4 "ASC TERT1: 63.3;HUVEC TERT2: 33.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002426, CAB002921, HPA029298, HPA069790" Enhanced Approved Vesicles "Secreted to blood" NA NA 104000000 170000000 "Cluster 43: B-cells - Humoral immune response" "Cluster 56: Intestine - Transmembrane transport" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 45: Enterocytes - Digestion" Vesicles "CAB002426: AB_442052, CAB002921: , HPA029298: AB_10960255, HPA069790: AB_2686197" "unprognostic (4.72e-2)" "unprognostic (4.16e-1)" "unprognostic (1.93e-3)" "unprognostic (6.06e-2)" "unprognostic (2.78e-1)" "unprognostic (1.35e-2)" "unprognostic (4.37e-1)" "unprognostic (1.54e-1)" "unprognostic (1.56e-1)" "unprognostic (1.25e-2)" "unprognostic (3.13e-2)" "unprognostic (2.38e-1)" "unprognostic (7.66e-2)" "unprognostic (9.07e-2)" "unprognostic (1.66e-1)" "unprognostic (1.08e-1)" "unprognostic (2.76e-2)" 13.4 4.9 1.7 4.8 8.1 0.1 8.1 0.2 2.5 18.1 0.5 11.2 176.4 8.1 3.5 4.1 6.3 8.2 10.4 1.3 1.0 10.8 1.9 49.0 4.9 1.3 0.9 1.9 6.2 18.7 9.2 11.6 1.3 8.9 6.1 0.4 7.6 23.8 16.1 3.8 265.1 9.6 0.8 2.8 8.3 101.9 2.0 0.8 19.2 10.0 2.1 5.5 3.8 1.1 0.0 0.0 0.0 0.0 2.6 63.3 0.6 2.4 4.7 0.0 0.0 0.9 5.1 1.3 1.8 11.4 0.1 0.0 3.1 0.0 0.0 0.0 1.4 6.6 0.0 0.0 1.4 0.0 0.0 4.2 0.0 0.1 0.0 1.2 33.8 0.0 5.8 0.0 0.1 1.1 0.0 1.4 0.4 11.7 0.7 0.1 0.5 0.9 0.0 0.0 8.2 5.6 0.0 0.0 0.0 1.3 2.9 0.4 0.0 0.1 0.2 0.5 0.1 0.0 0.0 0.0 1.0 0.0 0.5 0.0 0.0 0.0 0.1 0.1 0.2 1.0 0.5 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 1.7 8.1 0.2 2.5 1.3 1.0 1.3 0.9 1.3 0.8 2.0 1.1 50.0 0.0 3.3 0.0 0.5 1.5 2.6 0.1 1.2 4.0 3.6 1.9 2.1 1.5 0.7 0.0 0.0 0.1 0.3 11.9 0.0 5.9 543.6 10.8 8.0 34.7 18.0 0.0 4.7 0.4 0.1 11.5 2.0 36.3 7.0 24.1 3.6 0.8 4.2 0.0 1.8 39.8 0.0 33.7 3.5 1322.9 4.4 13.6 3.6 4.7 0.0 1.8 0.0 1.0 0.2 0.7 40.9 2.6 0.1 4.2 1172.8 21.7 0.0 1.1 0.0 2.0 4.2 13.5 6.4 0.2 0.1 0.1 2.2 0.3 26.2 2.1 ACE2 ENSG00000130234 "Angiotensin I converting enzyme 2" Q9BYF1 X 15494566-15607236 "Enzymes, Metabolic proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters" "Host-virus interaction" "Carboxypeptidase, Host cell receptor for virus entry, Hydrolase, Metalloprotease, Protease, Receptor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 65.5;intestine: 242.2;kidney: 87.6" "Cell type enriched" "Detected in many" 5 "Proximal enterocytes: 294.8" "Group enriched" "Detected in many" 4 "colorectal cancer: 13.9;renal cancer: 26.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "NB-4: 1.2;NTERA-2: 1.2;SuSa: 1.9" "Low region specificity" "Detected in all" "Not detected" "Not detected" "HPA000288, CAB026174, CAB026213, CAB080024, CAB080025, CAB080027, CAB080028" Enhanced "Secreted to blood" NA NA 400000 "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 5: NTERA-2 - Transcription" "Cluster 45: Enterocytes - Digestion" "CAB026174: , CAB026213: , CAB080024: AB_10864415, CAB080025: AB_2809589, CAB080027: AB_2665870, CAB080028: AB_2665871, HPA000288: AB_1078160" "unprognostic (1.40e-1)" "unprognostic (7.26e-2)" "unprognostic (2.76e-2)" "unprognostic (5.71e-2)" "unprognostic (2.51e-1)" "unprognostic (5.26e-2)" "prognostic favorable (4.21e-4)" "unprognostic (2.34e-2)" "unprognostic (6.74e-3)" "unprognostic (2.54e-3)" "unprognostic (1.00e-1)" "unprognostic (1.74e-1)" "prognostic favorable (2.12e-5)" "unprognostic (1.94e-1)" "unprognostic (9.62e-2)" "unprognostic (2.11e-1)" "unprognostic (7.10e-2)" 8.9 0.5 0.1 1.4 0.1 0.6 4.3 0.4 0.3 0.6 1.9 9.9 183.3 0.5 0.5 1.8 1.5 65.5 42.7 0.2 0.2 87.6 5.7 0.8 0.4 0.2 0.2 1.8 2.5 1.5 0.1 1.2 0.2 0.4 5.9 0.3 1.4 4.1 0.7 0.3 242.2 0.5 0.1 0.1 2.6 49.7 0.2 0.5 4.5 0.5 0.2 0.8 1.2 0.2 0.0 0.0 0.3 0.0 0.2 0.0 0.8 0.1 0.0 0.2 0.2 0.2 0.3 0.4 0.3 0.0 0.3 0.7 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.1 0.0 0.1 0.0 0.2 0.0 0.5 1.2 1.2 0.0 0.0 0.3 0.2 0.5 0.2 0.4 0.2 0.9 0.0 0.4 0.0 1.9 0.4 0.4 0.1 0.0 0.0 0.3 0.4 0.1 0.5 0.5 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.2 0.1 0.1 0.4 0.3 0.2 0.2 0.2 0.2 0.2 0.1 0.2 0.2 0.4 0.0 0.5 1.3 1.4 0.1 0.5 5.0 0.0 0.0 1.6 0.0 11.2 55.8 2.6 0.0 0.0 4.2 0.1 22.9 3.9 1.2 0.5 1.1 0.3 1.0 7.2 0.0 0.8 0.8 0.3 4.6 0.0 0.6 0.0 3.9 0.0 0.9 0.8 0.0 0.8 8.2 0.0 0.0 0.0 1.4 8.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.9 5.1 6.0 0.0 1.0 294.8 48.8 2.0 0.0 19.7 0.0 8.9 1.1 1.0 0.0 0.1 12.7 0.3 0.1 10.6 2.2 ACOX1 PALMCOX ENSG00000161533 "Acyl-CoA oxidase 1" Q15067 17 75941507-75979177 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" Oxidoreductase "Deafness, Disease variant, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 191.5" "Cell type enhanced" "Detected in many" "Distal enterocytes: 199.8;Hepatocytes: 287.4;Proximal enterocytes: 238.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "basophil: 77.2;neutrophil: 113.7" "Lineage enriched" "Detected in all" 6 "granulocytes: 113.7" "Cell line enhanced" "Detected in all" "BEWO: 96.9;RT4: 129.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB021094, HPA021192, HPA021195, HPA028759" Approved Approved Nucleoli,Peroxisomes NA NA 96000 "Cluster 50: Neutrophils - Cellular senescence" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 15: RT4 - Unknown function" "Cluster 45: Enterocytes - Digestion" Peroxisomes Nucleoli "CAB021094: AB_10261667, HPA021192: AB_1844527, HPA021195: AB_1844528, HPA028759: AB_10601352" "unprognostic (7.47e-2)" "unprognostic (3.69e-1)" "unprognostic (1.25e-3)" "unprognostic (1.36e-1)" "unprognostic (7.49e-2)" "unprognostic (8.14e-2)" "unprognostic (3.75e-2)" "unprognostic (4.95e-2)" "unprognostic (1.61e-1)" "unprognostic (5.33e-2)" "unprognostic (1.25e-1)" "unprognostic (3.38e-2)" "prognostic favorable (5.25e-7)" "unprognostic (3.39e-1)" "unprognostic (2.41e-2)" "unprognostic (1.72e-1)" "unprognostic (4.46e-2)" 37.8 18.1 16.1 10.6 18.2 8.8 17.1 17.4 15.1 11.0 21.3 40.9 62.5 9.3 9.8 30.4 9.9 14.9 23.0 14.3 17.5 40.3 191.5 13.6 6.2 16.6 17.9 9.5 39.7 18.8 12.6 17.3 15.9 18.4 27.1 16.1 15.4 11.8 30.1 24.8 51.4 11.1 17.5 10.5 27.4 9.3 20.6 8.3 17.0 29.2 12.1 19.5 12.7 18.9 16.3 24.5 7.2 9.9 34.0 14.4 96.9 11.8 11.3 12.9 14.8 16.4 24.0 9.1 14.0 17.9 12.5 9.9 28.7 12.4 19.2 10.0 9.5 10.9 13.1 47.2 19.4 9.7 7.8 24.0 9.4 15.7 9.2 13.1 32.3 13.6 12.3 8.9 14.0 45.3 26.3 7.0 4.9 36.8 19.8 13.4 21.3 10.2 20.7 129.1 8.7 12.6 30.6 46.5 11.4 21.2 32.6 11.3 20.9 18.2 13.4 15.2 11.5 14.4 11.0 4.0 10.0 9.7 11.4 77.2 18.3 5.2 6.9 14.2 8.2 5.4 6.6 8.8 10.3 4.5 7.2 7.1 113.7 7.2 9.4 9.4 9.3 8.0 16.1 18.2 17.4 15.1 14.3 17.5 16.6 17.9 15.9 17.5 20.6 18.9 28.0 28.9 25.0 25.1 10.8 13.5 15.9 26.1 21.1 27.4 19.4 13.5 47.4 51.5 23.4 23.9 22.9 37.7 12.1 199.8 21.5 22.9 11.6 18.1 16.7 18.8 34.4 21.5 17.8 40.6 46.5 19.8 88.7 24.1 17.1 21.4 21.8 287.4 25.4 18.5 18.8 44.5 24.4 35.4 14.1 7.1 29.8 23.7 14.2 15.0 36.3 61.9 9.2 22.1 18.2 34.2 100.0 47.0 18.3 24.0 238.7 107.8 17.4 28.4 0.0 18.4 17.2 5.5 11.0 28.5 30.3 43.2 13.2 17.1 41.9 31.7 ACOX3 ENSG00000087008 "Acyl-CoA oxidase 3, pristanoyl" O15254 4 8366282-8440723 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Syncytiotrophoblasts: 74.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035840, HPA035841" Uncertain Supported Peroxisomes NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Peroxisomes "HPA035840: AB_10696514, HPA035841: AB_10671940" "unprognostic (3.07e-2)" "unprognostic (5.51e-2)" "unprognostic (1.12e-1)" "prognostic favorable (2.16e-4)" "unprognostic (5.52e-2)" "unprognostic (1.81e-3)" "unprognostic (2.21e-1)" "unprognostic (3.37e-2)" "unprognostic (2.27e-1)" "unprognostic (4.43e-2)" "unprognostic (4.81e-1)" "unprognostic (1.39e-1)" "unprognostic (1.46e-2)" "unprognostic (3.58e-2)" "unprognostic (2.84e-1)" "unprognostic (1.69e-1)" "unprognostic (2.65e-1)" 7.7 8.8 5.8 6.4 5.2 4.4 12.2 3.8 7.2 9.5 5.9 8.4 8.9 5.6 4.3 26.6 6.6 5.9 16.2 5.3 4.9 6.5 14.9 7.2 6.6 5.9 4.6 7.5 12.0 7.1 4.5 8.4 4.7 10.5 6.3 3.8 15.4 8.4 6.4 12.5 8.9 11.4 4.2 5.3 10.1 2.9 5.0 4.6 8.5 5.6 8.5 10.1 13.7 7.1 8.9 9.6 10.5 14.1 11.0 18.7 17.2 11.1 15.1 18.5 16.1 4.8 11.7 11.9 11.7 22.8 25.0 5.4 4.6 14.4 14.3 4.1 4.5 5.2 8.2 14.8 18.3 10.7 9.4 18.9 12.1 16.7 6.5 13.3 22.1 13.1 7.0 10.6 16.1 8.2 11.4 15.6 5.9 11.3 16.4 11.8 17.3 14.3 11.2 12.4 5.1 11.7 14.2 7.2 7.3 8.6 7.2 14.9 21.7 18.2 5.9 7.5 11.8 7.9 5.6 5.4 23.2 13.1 11.8 0.1 13.2 3.3 6.1 15.2 6.3 5.4 7.1 7.8 17.8 4.9 6.5 6.7 3.1 9.5 14.4 21.4 10.4 9.4 5.8 5.2 3.8 7.2 5.3 4.9 5.9 4.6 4.7 4.2 5.0 7.1 6.2 6.4 5.9 14.7 4.8 4.5 7.6 12.3 8.6 8.2 11.6 7.6 9.4 10.0 9.8 11.0 33.3 23.9 7.7 10.9 3.9 17.3 4.4 13.1 4.2 5.6 1.8 3.0 13.2 13.7 9.3 6.6 10.2 10.0 0.0 21.7 4.6 14.2 10.2 1.7 14.2 4.9 14.2 4.1 4.4 3.3 6.8 5.3 5.4 6.5 7.6 3.8 2.1 12.5 14.5 16.9 7.4 11.3 5.6 9.1 18.3 8.2 11.2 18.6 0.0 3.8 6.9 2.4 2.3 14.1 5.8 74.6 6.0 6.0 7.5 11.4 ADH1A ADH1 ENSG00000187758 "Alcohol dehydrogenase 1A (class I), alpha polypeptide" P07327 4 99276369-99291003 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Oxidoreductase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 306 "liver: 2739.1" "Cell type enriched" "Detected in some" 12 "Hepatocytes: 200.9" "Cancer enriched" "Detected in some" 251 "liver cancer: 165.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 7 "ASC diff: 8.2" "CAB009562, HPA047814, HPA060902" Enhanced Approved "Plasma membrane,Cytosol" NA NA 38000000 "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 2: Hepatocytes - Metabolism" "Plasma membrane, Cytosol" "CAB009562: AB_2257984, HPA047814: AB_2680163, HPA060902: AB_2684384" "unprognostic (5.89e-2)" "unprognostic (6.16e-2)" "unprognostic (1.20e-1)" "unprognostic (2.07e-1)" "unprognostic (4.40e-1)" "prognostic favorable (2.38e-4)" "unprognostic (2.78e-3)" "unprognostic (4.25e-1)" "unprognostic (4.79e-3)" "unprognostic (6.21e-2)" "unprognostic (9.36e-2)" "unprognostic (3.25e-2)" "unprognostic (1.40e-1)" "unprognostic (2.86e-2)" 7.2 1.6 0.0 0.4 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.3 8.9 0.3 0.5 0.1 0.5 6.6 0.3 0.0 0.0 0.7 2739.1 0.8 0.0 0.1 0.1 0.1 1.1 0.0 0.3 0.1 0.0 0.0 0.3 0.0 0.2 0.0 0.1 0.1 1.8 0.0 0.1 0.3 0.4 0.3 0.0 0.0 0.1 1.0 0.1 0.3 0.1 0.1 0.0 0.0 0.0 0.0 8.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 15.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.5 0.1 0.1 0.3 0.0 10.7 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 8.6 200.9 0.0 0.0 0.0 0.0 0.0 9.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.3 0.2 0.1 0.0 0.0 0.5 0.0 0.0 0.0 ADH1B ADH2 ENSG00000196616 "Alcohol dehydrogenase 1B (class I), beta polypeptide" P00325 4 99304971-99352760 "Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Oxidoreductase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 1501.5;liver: 5858.7" "Cell type enriched" "Detected in many" 6 "Hepatocytes: 4153.7" "Cancer enriched" "Detected in many" 31 "liver cancer: 223.1" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 7 "ASC diff: 6574.3" "HPA047814, HPA060902" Supported Approved "Plasma membrane,Cytosol" NA NA 39000000 "Cluster 85: Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 2: Hepatocytes - Metabolism" "Plasma membrane, Cytosol" "HPA047814: AB_2680163, HPA060902: AB_2684384" "unprognostic (5.13e-2)" "unprognostic (9.80e-3)" "unprognostic (6.59e-2)" "unprognostic (5.56e-2)" "unprognostic (9.49e-2)" "unprognostic (5.53e-2)" "unprognostic (1.54e-3)" "unprognostic (1.04e-2)" "unprognostic (6.51e-2)" "unprognostic (2.73e-2)" "unprognostic (7.47e-3)" "unprognostic (7.79e-2)" "prognostic unfavorable (7.87e-4)" "unprognostic (4.60e-3)" "unprognostic (2.33e-1)" "unprognostic (2.58e-1)" "unprognostic (1.60e-2)" 1501.5 140.2 2.2 36.4 3.4 0.1 924.6 1.9 9.0 41.0 13.5 202.2 38.5 161.4 74.8 105.8 385.0 145.1 215.3 2.0 1.9 66.7 5858.7 373.2 25.8 4.7 2.2 117.7 49.1 7.8 24.2 6.8 3.2 26.7 114.7 0.1 67.9 26.7 66.6 159.2 237.1 73.4 4.4 72.7 141.1 2.8 2.2 19.8 94.5 228.2 16.0 287.9 118.7 2.4 0.0 0.0 0.0 0.0 6574.3 956.7 0.2 0.0 2.0 0.0 0.0 0.0 0.0 0.7 0.1 1.1 0.0 0.0 0.5 1.4 0.0 0.1 0.0 1.1 0.1 0.0 26.9 3.0 0.0 216.8 0.1 0.0 0.8 0.0 0.0 0.0 0.5 0.0 0.1 0.0 0.1 0.5 0.1 0.0 0.0 0.1 3.2 0.1 0.0 0.0 0.1 0.2 1.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.5 0.2 0.2 0.3 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 3.4 1.9 9.0 2.0 1.9 4.7 2.2 3.2 4.4 2.2 2.4 29.0 0.0 3.4 0.0 8.1 22.3 0.5 0.1 6.8 0.1 1.1 2.5 12.2 110.1 2.3 0.0 0.0 0.1 1.5 0.0 0.0 0.0 0.6 0.1 0.9 14.7 0.0 115.0 0.0 0.0 0.1 633.1 11.2 0.0 1.3 0.0 96.8 4153.7 0.1 0.0 0.0 0.0 0.0 98.8 25.4 0.6 55.3 3.5 28.4 1.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 7.1 0.7 0.0 0.1 0.2 0.1 6.6 15.0 47.9 0.0 0.1 10.4 13.1 0.1 8.9 0.1 0.0 0.2 ADH1C ADH3 ENSG00000248144 "Alcohol dehydrogenase 1C (class I), gamma polypeptide" P00326 4 99336497-99352746 "Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Oxidoreductase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 21 "intestine: 598.1;liver: 2062.2;stomach 1: 570.6" "Cell type enhanced" "Detected in many" "Exocrine glandular cells: 699.4;Gastric mucus-secreting cells: 611.2;Hepatocytes: 440.6;Undifferentiated cells: 420.5" "Cancer enriched" "Detected in many" 7 "liver cancer: 238.2" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 2.1;ASC TERT1: 3.6;HSkMC: 11.9;RPMI-8226: 2.1" "HPA047814, HPA060902" Supported Supported "Plasma membrane,Cytosol" NA NA 31000000 "Cluster 85: Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 1: Pancreatic cells - Digestion" "Plasma membrane, Cytosol" "HPA047814: AB_2680163, HPA060902: AB_2684384" "unprognostic (3.98e-2)" "unprognostic (9.88e-3)" "unprognostic (7.04e-2)" "unprognostic (1.90e-1)" "unprognostic (5.14e-1)" "unprognostic (1.57e-1)" "prognostic favorable (4.55e-4)" "prognostic favorable (2.99e-4)" "unprognostic (8.25e-2)" "unprognostic (8.89e-3)" "unprognostic (7.95e-2)" "unprognostic (2.04e-1)" "unprognostic (1.12e-1)" "unprognostic (1.21e-1)" "unprognostic (1.53e-1)" "unprognostic (1.70e-1)" "unprognostic (9.37e-2)" 22.9 0.8 0.1 29.8 0.1 0.0 19.2 0.1 0.1 4.7 0.0 329.5 598.1 5.1 7.2 5.1 5.8 51.6 5.9 0.1 0.0 19.6 2062.2 2.9 0.6 0.1 0.1 4.0 16.7 0.1 1.6 0.1 0.1 9.4 191.9 0.0 19.3 6.2 23.9 0.7 190.7 16.3 0.1 0.7 570.6 0.8 0.1 0.5 2.9 31.1 0.5 5.9 3.6 0.2 0.0 2.1 0.0 0.0 1.4 3.6 0.9 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.1 0.2 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.4 0.3 0.0 0.2 1.1 0.3 11.9 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.3 0.8 0.2 0.0 0.1 0.1 0.8 2.1 0.8 0.0 0.3 1.1 0.5 0.7 0.0 0.0 0.2 0.0 0.1 0.0 0.4 0.3 0.1 0.1 0.0 0.3 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.2 2.1 3.2 7.3 0.7 1.3 0.0 4.0 0.0 25.0 0.0 0.1 0.3 1.0 64.3 24.8 29.5 0.0 0.0 0.1 108.4 0.0 159.5 2.3 1.3 0.8 1.2 21.6 29.5 0.3 699.4 0.0 21.1 611.2 1.3 0.0 0.0 13.2 440.6 0.0 0.0 0.2 86.3 0.0 13.2 0.0 1.0 10.5 0.8 0.0 0.0 2.0 0.0 0.0 0.5 0.1 66.3 120.8 0.0 0.6 3.1 59.4 1.4 43.7 0.0 0.0 1.3 2.0 0.0 0.7 10.6 0.0 0.0 1.8 1.6 420.5 3.6 ADH4 ADH-2 ENSG00000198099 "Alcohol dehydrogenase 4 (class II), pi polypeptide" P08319 4 99123657-99157792 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 31 "liver: 5151.4" "Cell type enriched" "Detected in some" 21 "Hepatocytes: 975.2" "Cancer enriched" "Detected in some" 60 "liver cancer: 230.7" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 13 "Hep G2: 22.2" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA020525 Enhanced Uncertain Nucleoplasm,Cytosol NA NA 20000000 "Cluster 34: Basophils - Unknown function" "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" "Nucleoplasm, Cytosol" "HPA020525: AB_1844609" "unprognostic (2.75e-1)" "unprognostic (1.69e-2)" "unprognostic (1.85e-2)" "unprognostic (5.54e-3)" "unprognostic (2.14e-2)" "unprognostic (1.33e-2)" "prognostic favorable (7.08e-6)" "unprognostic (1.49e-1)" "unprognostic (1.39e-2)" "unprognostic (6.91e-2)" "unprognostic (1.88e-1)" "unprognostic (2.34e-2)" "unprognostic (7.16e-3)" "unprognostic (2.20e-1)" "unprognostic (5.89e-3)" 2.1 0.8 0.5 0.4 0.4 0.4 4.3 1.2 1.0 1.5 0.0 0.6 164.1 0.2 0.5 0.8 0.3 0.4 0.2 0.4 0.7 1.5 5151.4 0.2 0.2 0.1 0.1 0.1 0.4 0.1 0.0 0.2 0.1 0.3 0.6 0.8 2.6 0.5 0.6 0.9 22.9 0.1 0.0 0.6 0.6 1.0 0.5 0.0 0.4 2.1 0.1 0.3 3.4 0.2 0.1 0.2 0.1 0.2 0.1 0.0 0.2 0.1 0.0 0.0 0.0 0.1 0.1 0.4 0.2 0.0 0.1 0.1 0.0 0.1 0.2 0.0 0.0 0.4 0.4 22.2 0.0 1.6 0.2 0.2 0.0 0.1 0.1 0.1 0.0 0.1 0.3 0.8 0.0 0.1 0.1 0.5 0.3 0.0 0.1 0.1 1.6 0.5 0.0 0.1 0.1 0.2 1.5 0.3 0.0 0.1 0.4 0.0 0.1 0.4 0.1 0.3 0.0 0.4 0.4 0.6 0.0 0.5 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.4 1.2 1.0 0.4 0.7 0.1 0.1 0.1 0.0 0.5 0.2 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 21.5 0.2 1.8 0.0 0.0 0.0 0.8 0.0 0.0 26.9 0.7 0.6 1.1 0.0 45.5 0.1 0.6 0.0 1.0 0.0 0.3 0.0 0.0 16.1 975.2 0.0 0.0 0.0 1.1 0.0 27.0 0.0 3.7 0.3 0.1 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.9 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 1.9 0.0 0.8 0.0 ADH5 "ADH-3, ADHX, FDH, GSNOR" ENSG00000197894 "Alcohol dehydrogenase 5 (class III), chi polypeptide" P11766 4 99070978-99088801 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA044578, HPA061919" Approved NA NA 5300000 "Cluster 48: NK-cells - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 39: Non-specific - Basic cellular processes" "HPA044578: AB_2679002, HPA061919: AB_2684638" "unprognostic (1.05e-1)" "unprognostic (1.63e-2)" "unprognostic (1.14e-3)" "prognostic favorable (9.90e-5)" "unprognostic (2.63e-1)" "unprognostic (1.58e-2)" "unprognostic (1.11e-1)" "unprognostic (9.48e-2)" "prognostic unfavorable (3.54e-4)" "unprognostic (1.47e-1)" "unprognostic (1.02e-2)" "unprognostic (1.22e-1)" "prognostic favorable (4.58e-10)" "unprognostic (1.79e-3)" "unprognostic (9.05e-2)" "unprognostic (1.15e-2)" "unprognostic (1.13e-1)" 141.5 71.3 48.3 52.5 48.2 28.5 111.9 48.0 56.0 92.7 55.8 158.8 94.2 134.8 142.2 114.4 95.9 69.3 124.3 45.9 54.6 175.4 264.1 73.5 51.3 47.6 48.5 118.4 49.4 50.1 41.4 60.9 47.9 116.2 100.8 36.0 65.4 124.6 80.9 54.8 94.3 118.0 49.7 51.6 91.3 52.2 48.6 83.3 79.2 75.8 55.5 158.9 73.9 51.4 84.0 66.9 194.8 110.0 344.7 316.0 116.6 136.6 237.6 143.8 125.2 77.1 96.7 96.5 77.5 197.8 92.8 69.8 135.0 188.7 137.7 69.9 56.6 67.1 83.3 306.7 332.2 118.4 51.9 287.3 143.1 108.3 84.7 151.0 112.8 99.8 125.8 53.3 192.3 94.9 160.4 105.4 156.7 20.6 79.8 115.4 108.9 50.9 230.2 96.0 74.0 97.0 82.7 96.6 155.9 141.8 78.2 82.2 85.4 130.5 82.9 86.4 95.2 55.9 74.4 135.4 134.2 77.4 135.7 21.8 21.2 35.8 32.6 18.9 29.5 26.0 35.3 30.4 23.8 26.2 34.0 31.9 3.0 51.3 14.1 20.5 49.5 32.8 48.3 48.2 48.0 56.0 45.9 54.6 47.6 48.5 47.9 49.7 48.6 51.4 69.0 105.8 78.2 22.9 48.1 39.6 85.9 257.5 109.3 31.8 32.1 74.3 127.4 78.6 94.3 55.2 10.4 290.1 51.8 80.4 197.6 94.8 24.0 146.9 159.1 56.3 79.7 45.8 14.3 83.8 277.2 131.2 37.8 113.0 26.6 83.3 47.2 188.0 118.1 38.7 12.0 101.8 87.5 48.6 27.1 22.0 187.4 43.4 53.4 15.9 63.2 152.4 77.2 27.6 13.9 78.4 86.0 255.1 41.5 34.9 95.2 316.0 56.8 46.5 111.7 55.6 127.7 30.5 48.5 74.9 23.0 83.0 58.5 147.0 104.8 68.1 ADH6 ADH-5 ENSG00000172955 "Alcohol dehydrogenase 6 (class V)" P28332 4 99202638-99219537 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 13 "liver: 703.8" "Group enriched" "Detected in some" 6 "Hepatocytes: 325.5;Proximal tubular cells: 92.4" "Cancer enriched" "Detected in many" 18 "liver cancer: 46.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "Hep G2: 44.7" "Not detected" "Not detected" "HPA067946, HPA069081" Enhanced NA NA 3400000 "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" "HPA067946: AB_2732776, HPA069081: AB_2732127" "unprognostic (1.38e-2)" "unprognostic (1.83e-2)" "unprognostic (5.82e-2)" "unprognostic (1.49e-3)" "unprognostic (8.49e-2)" "unprognostic (1.08e-1)" "unprognostic (5.11e-3)" "unprognostic (2.40e-1)" "unprognostic (3.60e-2)" "unprognostic (1.35e-1)" "unprognostic (9.72e-3)" "unprognostic (1.67e-1)" "unprognostic (3.66e-3)" "unprognostic (1.35e-1)" "unprognostic (2.43e-1)" "unprognostic (8.74e-3)" "unprognostic (3.86e-3)" 0.2 0.0 0.1 0.6 0.0 0.0 0.1 0.0 0.0 0.2 0.0 8.2 41.5 0.3 0.0 0.3 9.2 7.7 0.0 0.0 0.0 52.3 703.8 0.2 0.2 0.1 0.2 0.0 0.3 0.0 0.0 0.2 0.1 0.1 8.6 0.0 0.0 0.1 0.0 1.8 22.6 0.3 0.1 0.1 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.3 0.0 0.5 0.2 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 44.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.3 0.1 9.0 0.1 0.0 0.3 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.0 0.2 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.1 0.0 0.3 0.0 0.0 0.5 0.0 0.7 0.5 0.1 0.5 0.0 0.0 0.0 0.0 0.3 15.7 1.1 5.5 0.0 0.0 0.0 7.8 7.9 0.3 0.0 11.2 0.3 0.4 12.1 0.0 0.1 0.2 0.0 0.1 0.0 0.4 0.0 0.0 7.1 325.5 0.0 0.0 0.1 8.9 8.2 5.3 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 2.2 0.0 0.0 0.0 31.1 92.4 15.6 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.9 0.0 12.7 0.1 ADH7 ADH-4 ENSG00000196344 "Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide" P40394 4 99412261-99435737 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "esophagus: 196.3" "Group enriched" "Detected in some" 4 "Basal respiratory cells: 89.0;Club cells: 64.1;Squamous epithelial cells: 209.1" "Cancer enhanced" "Detected in some" "cervical cancer: 18.4;head and neck cancer: 18.9;lung cancer: 22.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "ASC TERT1: 1.0;HaCaT: 1.2" "Not detected" "Not detected" HPA039695 Enhanced Supported "Plasma membrane,Cytosol" NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 61: Squamous epithelial cells - Keratinization" "Plasma membrane, Cytosol" "HPA039695: AB_10795681" "unprognostic (1.02e-2)" "unprognostic (8.64e-2)" "unprognostic (4.86e-2)" "unprognostic (5.66e-3)" "unprognostic (4.50e-2)" "unprognostic (1.66e-1)" "unprognostic (2.02e-1)" "unprognostic (1.88e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 196.3 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 22.8 0.0 0.0 0.7 0.0 0.0 0.0 0.0 27.3 0.0 0.0 0.2 0.0 0.0 38.1 0.3 4.6 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 89.0 21.1 0.0 0.0 0.0 0.2 0.0 64.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.1 0.0 0.0 0.1 7.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 18.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.2 0.6 0.0 0.0 26.2 0.0 0.0 0.0 2.3 0.0 0.0 209.1 0.0 0.0 0.0 0.0 0.0 1.0 ADHFE1 FLJ32430 ENSG00000147576 "Alcohol dehydrogenase iron containing 1" Q8IWW8 8 66432492-66468907 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 31.2;skeletal muscle: 29.2;tongue: 31.3" "Cell type enhanced" "Detected in many" "Astrocytes: 76.4;Cardiomyocytes: 41.6;Syncytiotrophoblasts: 116.4" "Cancer enhanced" "Detected in many" "liver cancer: 7.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC diff: 1.2;RPTEC TERT1: 1.5" "Low region specificity" "Detected in all" HPA023062 Enhanced Approved Vesicles NA NA "Cluster 24: B-cells - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Vesicles "HPA023062: AB_1844611" "prognostic favorable (5.76e-5)" "unprognostic (8.69e-2)" "unprognostic (6.71e-2)" "unprognostic (2.70e-1)" "unprognostic (1.14e-1)" "unprognostic (1.22e-1)" "prognostic favorable (9.90e-5)" "unprognostic (7.76e-3)" "unprognostic (2.88e-1)" "unprognostic (1.32e-1)" "unprognostic (1.59e-1)" "unprognostic (9.43e-2)" "prognostic favorable (4.55e-5)" "unprognostic (1.37e-2)" "unprognostic (2.06e-1)" "unprognostic (4.66e-2)" "unprognostic (5.94e-3)" 7.0 2.3 8.7 0.3 8.5 0.0 3.9 7.2 11.7 2.3 10.4 3.9 0.6 2.0 1.3 1.3 5.6 0.7 24.5 8.2 8.2 6.6 31.2 2.1 0.3 8.3 8.5 5.1 9.4 5.0 2.6 1.1 8.1 5.2 0.7 1.5 2.3 1.5 29.2 1.1 2.5 0.2 7.8 1.8 11.0 1.7 8.7 0.3 2.7 31.3 0.3 4.4 1.8 8.5 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.8 0.0 0.0 0.5 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.1 0.0 0.0 0.1 0.3 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.6 0.2 0.0 0.2 0.0 0.5 0.1 0.0 0.3 0.0 0.4 0.1 0.3 0.0 0.7 0.0 0.0 0.0 0.0 8.7 8.5 7.2 11.7 8.2 8.2 8.3 8.5 8.1 7.8 8.7 8.5 1.5 9.6 20.1 76.4 1.8 1.0 4.1 2.7 3.4 1.7 4.6 4.6 41.6 14.3 9.6 9.2 10.4 8.8 6.5 1.0 11.7 1.5 0.5 2.5 1.6 3.3 3.6 2.5 8.3 0.6 0.9 5.3 8.6 2.5 8.8 6.1 6.1 27.1 2.5 0.0 13.2 2.0 4.1 2.1 2.8 1.6 23.9 2.1 0.0 14.0 2.0 7.6 6.2 21.6 19.2 0.9 5.8 27.1 3.0 3.5 4.1 14.8 14.3 8.5 0.0 7.8 5.2 0.5 0.6 1.9 1.0 116.4 10.0 2.5 2.4 2.5 ALDH1A3 "ALDH6, RALDH3" ENSG00000184254 "Aldehyde dehydrogenase 1 family member A3" P47895 15 100877714-100916626 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Disease variant, Microphthalmia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "prostate: 134.5;urinary bladder: 125.1" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 175.4;Endometrial stromal cells: 247.9;Leydig cells: 194.5;Prostatic glandular cells: 580.3;Urothelial cells: 468.7" "Cancer enriched" "Detected in many" 5 "prostate cancer: 80.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 363.3;HaCaT: 441.7;HBEC3-KT: 1096.9;hTERT-RPE1: 347.7;U-2197: 619.0;U-87 MG: 484.7;WM-115: 516.1" "Low region specificity" "Detected in many" "Group enriched" "Detected in many" 4 "olfactory bulb: 4.5;spinal cord: 15.8" "HPA046271, HPA064749" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 22: Epithelial cell types - Mixed function" Nucleoplasm Cytosol "HPA046271: AB_10965992, HPA064749: AB_2685344" "unprognostic (6.87e-2)" "unprognostic (2.23e-1)" "unprognostic (6.20e-3)" "unprognostic (1.21e-3)" "unprognostic (1.76e-2)" "unprognostic (1.14e-1)" "unprognostic (6.28e-2)" "unprognostic (5.46e-2)" "unprognostic (9.62e-2)" "unprognostic (4.53e-2)" "unprognostic (3.64e-2)" "unprognostic (2.56e-1)" "unprognostic (1.25e-2)" "unprognostic (2.61e-2)" "unprognostic (2.12e-1)" "unprognostic (7.34e-2)" "unprognostic (6.07e-3)" 83.7 11.4 3.0 41.5 2.7 0.6 30.5 4.7 5.2 37.1 16.2 16.6 15.0 8.2 30.3 28.7 24.9 17.0 12.4 3.1 1.9 8.2 5.3 9.8 3.0 4.8 3.4 6.1 15.0 9.0 7.5 8.4 2.6 134.5 8.9 0.3 93.7 49.3 5.9 3.9 25.2 40.8 2.8 3.1 12.8 16.6 3.3 1.6 2.5 6.9 15.7 125.1 22.3 3.9 363.3 43.5 0.6 0.7 75.0 32.8 1.4 3.2 3.2 1.9 0.8 1.0 285.8 2.6 4.7 97.1 55.7 441.7 8.8 1096.9 6.7 0.1 2.0 1.7 20.1 0.3 25.5 1.4 1.9 23.5 29.8 24.4 4.5 347.7 4.0 0.0 0.7 2.4 1.8 3.8 0.2 1.2 9.0 9.6 316.3 0.7 4.2 2.3 0.2 283.6 0.3 25.4 113.9 94.9 33.3 3.6 9.3 3.2 58.3 0.3 1.0 619.0 14.2 0.7 3.4 1.5 484.7 0.2 516.1 0.3 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 3.0 2.7 4.7 5.2 3.1 1.9 4.8 3.4 2.6 2.8 3.3 3.9 10.0 16.0 6.3 0.3 0.5 0.6 175.4 70.5 4.6 0.0 64.6 18.9 2.0 1.5 141.6 103.0 0.0 9.6 0.9 1.0 3.9 70.5 1.2 20.6 247.9 11.6 3.5 0.0 2.9 1.4 0.5 48.9 1.1 11.7 5.7 0.0 1.8 0.1 1.2 0.0 2.3 2.1 30.5 0.0 1.3 8.5 194.5 3.3 0.0 1.0 0.6 0.0 0.0 36.7 4.6 29.4 0.0 135.4 0.0 580.3 0.1 0.7 78.7 0.0 13.1 20.4 11.5 0.5 0.9 2.9 1.6 4.9 2.0 1.5 0.8 468.7 ALDH3A1 ALDH3 ENSG00000108602 "Aldehyde dehydrogenase 3 family member A1" P30838 17 19737984-19748943 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 496.1;salivary gland: 128.0;stomach 1: 224.8" "Group enriched" "Detected in many" 4 "Basal respiratory cells: 389.5;Basal squamous epithelial cells: 274.3;Club cells: 150.1;Gastric mucus-secreting cells: 437.9;Respiratory ciliated cells: 412.7;Squamous epithelial cells: 342.2" "Cancer enhanced" "Detected in many" "head and neck cancer: 64.4;lung cancer: 60.4" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 23 "A549: 5094.7;OE19: 6071.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "CAB045957, HPA051150, HPA063783" Enhanced Supported "Nucleoplasm,Vesicles,Plasma membrane,Cytosol" No No 52000 "Cluster 22: NK-cells - Unknown function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 21: OE19 - Mitochondria" "Cluster 61: Squamous epithelial cells - Keratinization" "Plasma membrane, Cytosol" "Nucleoplasm, Vesicles" "CAB045957: AB_11127164, HPA051150: AB_2681364, HPA063783: AB_2685122" "unprognostic (3.11e-5)" "unprognostic (1.20e-2)" "unprognostic (1.08e-1)" "unprognostic (7.04e-3)" "unprognostic (4.36e-3)" "prognostic favorable (7.55e-5)" "unprognostic (3.12e-1)" "unprognostic (3.84e-1)" "unprognostic (2.10e-1)" "unprognostic (1.67e-1)" "unprognostic (2.69e-3)" "unprognostic (5.54e-2)" "unprognostic (1.72e-1)" "unprognostic (3.84e-2)" "unprognostic (1.83e-1)" "unprognostic (2.88e-2)" "unprognostic (7.23e-2)" 1.7 1.0 0.4 1.3 0.7 0.1 3.2 0.3 0.4 6.7 17.5 4.5 6.2 0.3 0.2 496.1 5.5 10.3 0.3 1.0 0.4 1.3 1.9 10.9 0.5 0.6 2.1 0.4 0.5 0.0 0.9 0.0 0.5 1.9 3.3 0.1 128.0 1.5 1.3 72.6 3.5 0.4 0.9 0.9 224.8 1.6 1.3 0.6 0.5 0.3 33.7 6.2 22.3 0.9 0.1 5094.7 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.2 10.7 246.5 0.0 2.7 0.5 2.0 29.3 0.7 12.8 0.0 0.0 0.8 0.1 116.6 1.0 0.3 0.1 0.5 0.0 14.9 0.5 0.4 0.2 0.5 0.0 0.0 0.0 0.0 9.7 0.1 0.3 0.4 6071.6 19.8 0.0 0.0 0.0 0.0 87.0 0.2 0.6 24.8 0.0 0.0 0.2 0.2 0.9 0.6 0.3 0.8 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.4 0.7 0.3 0.4 1.0 0.4 0.6 2.1 0.5 0.9 1.3 0.9 0.7 3.2 5.5 0.0 0.7 44.1 46.8 389.5 274.3 0.0 0.1 1.5 0.4 2.8 150.1 0.0 0.0 0.0 0.0 5.1 0.0 1.4 1.5 12.4 0.2 1.3 1.8 0.0 0.1 0.5 0.0 1.6 437.9 0.8 2.5 0.3 1.4 3.2 0.2 0.0 0.0 4.8 83.4 0.3 1.8 5.2 0.9 1.0 0.0 0.0 0.0 1.9 0.0 0.0 0.1 9.5 4.7 1.9 3.2 5.8 3.4 5.0 412.7 0.2 0.0 1.7 20.1 1.7 8.6 342.2 32.0 0.0 0.5 0.2 8.4 64.3 ALDH3B1 ALDH7 ENSG00000006534 "Aldehyde dehydrogenase 3 family member B1" P43353 11 68008578-68029282 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 46.5" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 115.4;Alveolar cells type 2: 58.4;Endometrial ciliated cells: 54.5;Kupffer cells: 59.0;Respiratory ciliated cells: 211.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 163.2" "Group enriched" "Detected in many" 10 "dendritic cells: 67.5;granulocytes: 163.2;monocytes: 125.8" "Cell line enhanced" "Detected in many" "A549: 154.4;CAPAN-2: 154.9;RPMI-8226: 85.9;U-87 MG: 89.1" "Low region specificity" "Detected in all" HPA038525 Uncertain NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 49: Ciliated cells - Cilium organization" "HPA038525: AB_2676062" "unprognostic (3.50e-1)" "unprognostic (4.22e-1)" "prognostic unfavorable (1.18e-4)" "unprognostic (1.56e-2)" "unprognostic (9.66e-3)" "unprognostic (9.73e-2)" "unprognostic (7.93e-3)" "unprognostic (2.62e-1)" "unprognostic (2.01e-1)" "unprognostic (1.06e-1)" "prognostic unfavorable (6.07e-4)" "unprognostic (8.27e-2)" "unprognostic (6.49e-3)" "unprognostic (1.00e-1)" "unprognostic (2.75e-2)" "unprognostic (6.69e-3)" "unprognostic (1.06e-1)" 12.7 26.7 2.9 10.6 4.5 46.5 5.5 5.1 4.2 11.4 8.9 9.8 23.4 6.4 0.9 13.9 39.6 8.8 4.0 2.5 3.8 16.3 4.1 44.4 5.6 6.0 5.6 3.6 8.0 0.6 7.7 11.7 4.9 4.7 6.5 0.5 11.1 4.1 2.0 5.7 18.0 5.6 4.5 20.0 20.7 2.1 5.4 1.3 2.5 1.7 2.6 10.8 8.9 6.2 11.4 154.4 1.1 3.3 9.9 31.0 26.8 15.1 24.8 10.9 5.3 5.7 154.9 0.7 26.9 35.9 15.3 12.9 0.3 2.1 2.7 0.4 0.9 1.6 64.3 13.4 61.0 9.1 0.5 22.5 6.8 5.4 14.6 24.6 0.6 0.8 0.4 27.3 17.8 9.5 0.9 9.0 1.2 76.1 9.2 3.7 5.9 85.9 17.9 1.5 1.8 0.8 35.7 29.7 15.2 0.8 34.3 19.7 16.2 15.7 21.3 76.2 5.3 0.4 3.0 0.2 89.1 24.5 7.4 47.6 91.0 163.2 0.2 125.8 0.3 0.4 0.2 0.2 67.5 0.5 0.2 0.1 26.6 11.8 118.1 7.0 0.1 47.7 2.9 4.5 5.1 4.2 2.5 3.8 6.0 5.6 4.9 4.5 5.4 6.2 0.4 115.4 58.4 1.0 1.4 2.2 2.7 8.4 1.2 0.5 1.7 1.3 3.1 20.0 53.6 5.5 0.0 0.8 2.9 6.6 0.0 7.4 21.6 54.5 9.2 1.8 2.4 7.8 0.2 2.5 8.2 6.5 12.8 5.1 25.2 2.0 1.4 2.3 34.0 3.3 0.1 9.0 12.2 59.0 10.6 10.0 1.8 33.1 3.6 1.9 30.9 2.1 1.0 0.5 5.7 19.3 7.5 1.5 1.3 3.1 36.2 30.1 211.6 0.4 0.0 6.9 6.5 0.4 0.4 1.0 1.0 0.7 2.2 0.0 9.8 6.2 ALDH3B2 ALDH8 ENSG00000132746 "Aldehyde dehydrogenase 3 family member B2" P48448 11 67662160-67681224 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Oxidoreductase "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "breast: 73.0;esophagus: 152.2;skin 1: 123.0;vagina: 41.0" "Cell type enhanced" "Detected in some" "Breast glandular cells: 26.2;Endometrial ciliated cells: 12.6;Glandular and luminal cells: 28.1;Squamous epithelial cells: 53.3;Suprabasal keratinocytes: 14.8;Syncytiotrophoblasts: 14.6" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "MCF7: 71.9;SK-BR-3: 70.7" "Low region specificity" "Detected in many" "Not detected" "Not detected" HPA045132 Approved NA NA "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 61: Squamous epithelial cells - Keratinization" "HPA045132: AB_10795993" "unprognostic (2.25e-1)" "unprognostic (2.41e-1)" "unprognostic (1.65e-1)" "unprognostic (8.65e-2)" "unprognostic (2.13e-1)" "unprognostic (6.09e-2)" "unprognostic (3.12e-2)" "unprognostic (6.32e-2)" "unprognostic (1.48e-1)" "unprognostic (5.56e-2)" "unprognostic (1.24e-2)" "unprognostic (1.40e-2)" "unprognostic (2.59e-2)" "unprognostic (1.61e-1)" "unprognostic (1.15e-2)" "unprognostic (5.92e-2)" 0.3 0.0 0.1 0.1 0.0 0.2 73.0 0.0 0.0 14.4 0.0 0.1 0.1 0.8 6.8 152.2 4.6 0.3 0.1 0.0 0.0 0.7 0.1 0.4 0.0 0.0 0.0 0.0 0.3 5.2 0.1 3.2 0.0 3.3 0.1 0.5 17.3 4.8 0.3 123.0 0.0 0.1 0.0 0.0 0.3 0.1 0.0 2.4 0.0 0.0 21.1 8.3 41.0 0.0 0.2 0.0 0.1 0.1 0.0 0.0 7.9 0.0 0.0 0.1 0.0 1.3 3.5 3.3 0.1 0.0 0.1 3.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 1.3 0.0 6.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 71.9 6.8 0.0 0.1 9.0 0.0 0.0 0.0 1.9 0.0 13.0 0.0 0.1 0.0 70.7 0.1 0.4 15.3 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.3 0.0 0.0 1.7 1.2 4.9 1.2 0.0 26.2 7.2 0.4 0.0 7.3 5.5 0.0 10.6 0.2 0.0 1.9 1.1 0.0 12.6 2.6 0.2 0.0 0.0 0.1 0.2 10.6 0.2 0.0 28.1 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 2.0 0.0 0.8 0.0 0.0 0.2 1.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.1 0.0 0.0 2.8 0.0 0.0 0.0 0.5 0.0 0.0 53.3 14.8 14.6 0.2 0.0 0.0 7.6 ALPL "HOPS, TNALP, TNAP, TNSALP" ENSG00000162551 "Alkaline phosphatase, biomineralization associated" P05186 1 21509397-21578410 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" Biomineralization Hydrolase "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 60.7" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 92.0;Breast myoepithelial cells: 32.4;Glandular and luminal cells: 43.3;Hepatic stellate cells: 40.7;Hepatocytes: 30.1;Proximal tubular cells: 43.9;Rod photoreceptor cells: 34.2" "Cancer enhanced" "Detected in all" "testis cancer: 199.6" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 90 "neutrophil: 379.1" "Lineage enriched" "Detected in many" 139 "granulocytes: 379.1" "Cell line enhanced" "Detected in many" "HSkMC: 176.9;hTEC/SVTERT24-B: 141.2;LHCN-M2: 103.7;NTERA-2: 41.2;SCLC-21H: 88.2;SuSa: 48.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007105, HPA008765, CAB020829" Enhanced Approved Cytosol "Intracellular and membrane" NA NA 13000000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 11: Alveolar cells - Smell perception" Cytosol "CAB020829: , HPA007105: AB_1078137, HPA008765: AB_1078138" "unprognostic (3.89e-2)" "unprognostic (1.27e-1)" "unprognostic (5.57e-2)" "unprognostic (1.19e-1)" "prognostic unfavorable (7.57e-4)" "unprognostic (3.05e-3)" "unprognostic (6.50e-3)" "unprognostic (1.01e-1)" "prognostic unfavorable (7.08e-4)" "unprognostic (1.17e-2)" "unprognostic (2.48e-3)" "unprognostic (1.74e-1)" "unprognostic (7.28e-2)" "unprognostic (1.73e-2)" "unprognostic (2.27e-1)" "unprognostic (9.70e-3)" "unprognostic (2.58e-1)" 24.7 60.7 19.5 27.9 16.7 4.2 22.9 18.0 25.8 3.4 26.0 5.0 2.6 5.8 1.3 4.1 10.4 3.9 16.4 17.8 18.8 45.7 56.3 54.9 6.4 21.7 17.7 2.8 3.9 3.3 9.3 3.1 22.4 7.1 1.5 18.8 6.4 9.2 1.1 4.2 7.5 3.5 18.2 45.5 4.7 4.2 21.3 1.5 8.6 5.7 5.9 9.7 3.3 17.3 0.0 0.2 5.2 0.2 0.8 6.6 11.4 0.4 2.4 0.9 1.5 1.0 0.0 2.4 7.7 0.0 0.1 0.1 31.3 0.2 0.6 0.0 2.1 0.0 3.5 3.9 1.8 0.0 0.7 176.9 0.0 141.2 0.5 0.0 0.0 0.0 0.2 0.0 103.7 0.0 0.1 0.0 41.2 0.2 0.0 0.0 3.8 0.2 0.1 0.0 88.2 1.2 0.0 0.1 0.3 48.1 0.2 0.0 0.0 5.2 4.3 0.1 0.0 0.3 0.0 0.1 0.9 0.0 0.8 0.0 0.0 4.2 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.5 0.0 0.0 379.1 0.0 0.0 0.0 0.0 0.1 19.5 16.7 18.0 25.8 17.8 18.8 21.7 17.7 22.4 18.2 21.3 17.3 25.9 3.2 92.0 0.3 3.8 0.1 0.6 8.2 0.6 2.5 6.6 32.4 2.1 2.8 17.6 0.0 0.0 0.1 0.1 0.0 7.9 0.0 1.4 15.0 2.2 26.5 0.0 5.7 0.9 0.0 0.3 6.8 0.0 43.3 7.6 10.6 40.7 30.1 0.1 1.7 0.3 0.0 12.2 1.6 0.3 8.5 0.3 1.0 0.0 18.7 0.0 6.0 0.0 6.0 0.2 0.0 0.0 0.0 0.3 1.7 0.0 43.9 3.6 34.2 0.0 0.3 5.1 0.4 14.0 0.2 0.4 1.5 1.0 8.0 0.0 0.3 BCKDHA "MSU, OVD1A" ENSG00000248098 "Branched chain keto acid dehydrogenase E1 subunit alpha" P12694 19 41397808-41425002 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Disease variant, Maple syrup urine disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 26.2;Gastric mucus-secreting cells: 23.4;Plasma cells: 25.0;Squamous epithelial cells: 27.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036640 Supported NA NA 7700 "Cluster 25: Monocytes - Inflammatory response" "Cluster 39: Non-specific - Mitochondria" "Cluster 29: U-266 - Adaptive immune response" "Cluster 59: Non-specific - Transcription" "HPA036640: AB_10671964" "unprognostic (4.50e-2)" "unprognostic (6.85e-2)" "unprognostic (1.14e-1)" "unprognostic (8.58e-3)" "unprognostic (1.26e-2)" "prognostic favorable (9.37e-4)" "unprognostic (2.41e-2)" "unprognostic (8.55e-2)" "unprognostic (1.82e-1)" "unprognostic (1.48e-2)" "unprognostic (1.12e-2)" "unprognostic (1.53e-1)" "prognostic favorable (5.33e-10)" "unprognostic (1.73e-1)" "unprognostic (1.37e-1)" "prognostic unfavorable (3.27e-5)" "unprognostic (9.66e-2)" 33.8 78.4 32.0 19.3 35.5 32.4 25.2 37.0 39.3 24.6 37.0 20.9 19.9 17.9 14.1 65.1 28.8 15.4 90.4 32.5 35.1 44.3 110.0 22.4 24.5 34.4 33.8 25.4 46.1 56.3 24.0 19.0 36.2 23.8 15.0 21.7 40.9 23.1 110.0 31.8 18.7 12.7 33.9 24.4 52.5 27.1 35.7 27.0 41.7 122.0 21.2 21.7 31.9 40.0 42.7 75.1 14.2 44.1 22.2 12.8 17.1 11.9 25.3 24.4 29.9 18.2 36.0 34.6 23.7 15.1 11.0 17.1 15.0 25.9 12.1 36.0 41.0 27.1 35.2 21.3 51.5 25.5 17.7 27.6 37.6 16.9 38.2 36.0 45.0 50.9 25.9 68.9 17.6 41.5 28.0 20.0 12.8 61.1 21.1 27.1 22.8 89.6 29.8 19.8 32.5 38.6 39.6 84.7 34.1 12.1 45.4 81.0 29.3 22.2 23.0 12.0 22.0 131.9 55.1 34.1 81.8 56.6 24.6 61.4 149.4 59.7 49.5 123.9 56.7 46.0 47.0 49.1 154.6 49.5 43.2 44.9 46.4 82.4 95.5 62.6 63.9 125.6 32.0 35.5 37.0 39.3 32.5 35.1 34.4 33.8 36.2 33.9 35.7 40.0 0.6 0.0 13.1 4.9 10.0 0.3 0.1 2.6 26.2 0.2 1.5 0.4 0.1 1.5 5.3 5.5 0.0 1.9 0.9 3.8 3.9 14.7 0.7 0.5 0.6 2.4 6.1 15.5 5.8 11.8 1.7 3.7 23.4 0.7 5.1 0.4 2.5 2.4 2.7 0.0 6.2 7.6 8.2 2.2 0.8 0.9 0.6 6.6 3.6 3.7 12.4 0.4 5.2 4.0 5.7 8.4 3.8 0.4 25.0 0.2 6.7 2.3 1.2 1.2 0.0 0.2 3.6 1.8 0.9 27.2 0.9 2.1 6.3 0.3 7.3 0.1 BCKDHB ENSG00000083123 "Branched chain keto acid dehydrogenase E1 subunit beta" P21953 6 80106647-80346270 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Disease variant, Maple syrup urine disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 78.4" "Cell type enhanced" "Detected in all" "Astrocytes: 296.5;Early spermatids: 110.9;Inhibitory neurons: 94.9;Oligodendrocyte precursor cells: 98.5;Oligodendrocytes: 101.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031580, HPA031956" Approved Supported Nucleoplasm,Nucleoli,Mitochondria "Intracellular and membrane" Yes No "Cluster 15: NK-cells - Transcription" "Cluster 85: Liver - Metabolism" "Cluster 32: U-937 - Innate immune response" "Cluster 64: Astrocytes - Nervous system maintenance" Mitochondria "Nucleoplasm, Nucleoli" "HPA031580: AB_10696054, HPA031956: " "unprognostic (4.23e-1)" "unprognostic (1.61e-1)" "unprognostic (9.50e-3)" "unprognostic (9.37e-3)" "unprognostic (1.66e-1)" "unprognostic (6.03e-2)" "unprognostic (6.84e-3)" "unprognostic (2.30e-2)" "unprognostic (1.94e-1)" "unprognostic (7.32e-3)" "unprognostic (2.67e-1)" "unprognostic (4.65e-2)" "prognostic favorable (5.54e-9)" "unprognostic (2.67e-1)" "unprognostic (1.12e-1)" "unprognostic (8.02e-2)" "unprognostic (1.49e-2)" 19.7 10.7 7.3 7.6 8.3 8.2 22.3 11.5 7.8 11.7 11.6 22.5 11.5 9.2 7.1 10.3 11.5 7.8 18.8 8.8 7.0 31.8 78.4 7.3 8.8 10.7 9.2 14.6 12.9 19.7 7.2 4.8 13.1 15.9 20.7 7.9 26.6 11.3 10.9 8.5 12.4 9.4 11.8 6.3 17.6 13.1 8.7 9.1 15.5 15.3 9.1 11.2 7.6 16.0 13.8 5.1 18.8 25.3 18.6 16.1 14.9 9.7 19.8 15.4 21.0 8.3 18.5 38.9 10.1 23.1 18.0 13.6 10.6 12.7 21.5 48.8 15.6 19.4 12.6 11.3 20.7 27.7 8.3 15.6 12.8 10.7 13.3 13.8 18.6 29.8 16.6 33.8 35.0 7.6 10.3 16.3 14.0 30.1 6.5 25.5 58.3 33.8 43.2 20.7 12.6 17.8 16.2 13.4 9.9 20.6 17.3 21.1 8.0 9.2 6.3 8.5 13.0 24.0 25.2 12.9 11.3 20.4 14.2 3.4 4.2 1.0 10.1 5.1 13.3 10.6 8.3 8.5 8.3 12.7 11.0 11.6 0.8 17.4 5.9 12.9 20.3 6.1 7.3 8.3 11.5 7.8 8.8 7.0 10.7 9.2 13.1 11.8 8.7 16.0 8.4 9.6 21.0 296.5 11.5 8.5 12.5 21.1 15.9 7.8 19.6 14.7 29.3 8.6 18.0 5.5 2.1 17.0 9.1 17.5 27.4 8.2 110.9 8.3 10.3 8.0 12.0 10.3 72.0 10.4 8.3 13.7 15.3 17.6 16.5 19.2 11.0 66.5 12.2 3.3 94.9 31.3 10.2 9.1 9.0 13.7 8.7 5.4 16.0 59.0 7.3 15.5 10.3 98.5 101.7 5.4 10.4 8.6 8.4 6.2 11.5 33.1 13.5 8.7 6.6 11.1 9.4 15.2 5.6 20.1 12.4 10.4 9.9 15.5 17.4 10.9 CA1 Car1 ENSG00000133742 "Carbonic anhydrase 1" P00915 8 85327608-85379014 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 55 "bone marrow: 1798.9;intestine: 2109.9" "Cell type enriched" "Detected in some" 4 "Erythroid cells: 11487.3" "Group enriched" "Detected in some" 10 "colorectal cancer: 3.4;stomach cancer: 0.9" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 987 "HEL: 1022.7" "Not detected" "Not detected" "Not detected" "Not detected" "HPA006558, CAB025790" Enhanced NA NA 4600000000 "Cluster 43: B-cells - Humoral immune response" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 36: HEL - Hemostasis" "Cluster 6: Erythroid cells - Oxygen transport" "CAB025790: , HPA006558: AB_1845989" "unprognostic (1.44e-1)" "unprognostic (7.56e-2)" "unprognostic (1.70e-1)" "unprognostic (3.57e-3)" "unprognostic (2.08e-2)" "unprognostic (1.66e-1)" "unprognostic (2.84e-2)" "unprognostic (2.03e-2)" "unprognostic (1.73e-2)" "unprognostic (6.12e-2)" "unprognostic (1.63e-1)" "unprognostic (1.04e-1)" "unprognostic (5.61e-2)" "unprognostic (3.01e-2)" "unprognostic (2.38e-1)" "unprognostic (3.95e-2)" 2.0 0.4 0.4 0.5 0.3 1798.9 2.1 1.0 1.5 0.3 0.0 1023.3 0.2 1.6 0.1 0.7 2.2 0.3 1.6 0.2 0.2 2.0 6.7 5.9 0.2 0.3 0.3 0.4 0.3 0.1 1.9 20.7 0.3 0.4 2109.9 0.4 1.1 1.8 1.0 1.4 1.8 30.7 0.1 35.4 2.3 0.2 0.5 0.5 0.9 3.4 0.1 0.4 0.5 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1022.7 0.0 0.5 0.0 0.2 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.8 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 2.8 0.4 0.3 1.0 1.5 0.2 0.2 0.3 0.3 0.3 0.1 0.5 0.6 0.0 0.0 0.0 4.2 11.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 2.8 0.0 0.0 0.0 0.0 0.0 2565.3 0.0 0.0 0.5 0.1 0.0 0.5 45.8 11487.3 11.8 0.0 0.0 0.1 0.0 0.1 22.3 0.0 4.2 4.4 0.0 0.0 12.1 159.4 0.0 11.4 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 1.0 13.0 2.2 0.0 754.9 0.0 0.1 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 3.4 0.1 298.4 0.0 CA12 HsT18816 ENSG00000074410 "Carbonic anhydrase 12" O43570 15 63321378-63381846 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins" Lyase "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 290.2;skin 1: 142.1" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 174.6;Distal enterocytes: 422.6;Paneth cells: 160.8;Squamous epithelial cells: 185.3;Suprabasal keratinocytes: 252.2;Undifferentiated cells: 138.8" "Cancer enhanced" "Detected in all" "renal cancer: 109.3" "Region enhanced" "Detected in many" "basal ganglia: 42.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 213.0;ASC TERT1: 213.0;RT4: 226.2;SK-BR-3: 177.9;T-47d: 286.8;U-138 MG: 300.5;U-87 MG: 361.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008773, CAB025181, CAB062549, CAB068179, HPA073203" Enhanced NA NA 52000 "Cluster 7: Kidney - Transmembrane transport" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB025181: , CAB062549: AB_2665617, CAB068179: AB_2665616, HPA008773: AB_1078394, HPA073203: AB_2686580" "unprognostic (2.01e-1)" "unprognostic (8.38e-3)" "unprognostic (3.47e-1)" "unprognostic (3.25e-3)" "unprognostic (2.73e-2)" "unprognostic (2.47e-2)" "unprognostic (7.48e-2)" "unprognostic (3.43e-3)" "unprognostic (2.29e-1)" "unprognostic (4.67e-2)" "prognostic unfavorable (3.80e-6)" "unprognostic (2.59e-1)" "unprognostic (1.51e-1)" "unprognostic (2.38e-1)" "unprognostic (6.56e-2)" "unprognostic (7.26e-2)" "unprognostic (1.21e-1)" 8.3 0.2 6.1 18.7 42.9 0.1 42.8 5.2 7.2 50.7 129.0 104.1 0.4 28.4 4.1 75.4 25.0 7.7 3.2 6.8 6.6 290.2 0.7 3.0 0.3 0.9 9.6 0.6 70.2 0.3 10.7 2.3 3.2 5.5 94.2 1.9 26.3 8.7 0.6 142.1 8.2 56.2 0.9 0.8 7.9 0.6 16.1 0.1 4.6 0.1 8.7 27.4 49.0 1.5 0.0 213.0 3.5 0.5 27.3 213.0 11.2 15.7 13.7 2.5 4.1 1.6 0.5 0.0 51.4 12.6 81.7 1.1 0.0 10.4 6.2 0.3 7.7 0.0 13.9 0.4 0.6 0.0 0.3 81.3 11.4 63.6 20.4 0.1 2.7 0.1 0.0 0.3 2.8 125.2 0.3 0.2 3.4 0.0 33.4 0.1 0.0 0.1 0.2 226.2 1.8 0.2 0.9 177.9 0.0 2.1 286.8 0.1 0.4 300.5 16.0 10.1 0.2 0.0 0.0 0.1 361.6 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.1 42.9 5.2 7.2 6.8 6.6 0.9 9.6 3.2 0.9 16.1 1.5 0.7 0.0 6.9 11.4 1.1 174.6 20.0 87.7 93.4 0.1 93.5 50.4 1.3 1.5 30.3 40.5 0.0 0.4 1.6 422.6 54.8 17.2 12.1 28.4 6.2 2.1 8.4 0.0 1.3 58.4 2.0 14.6 8.2 75.0 1.3 0.3 0.0 0.2 0.6 0.0 0.8 111.4 20.3 0.3 11.9 3.9 0.0 4.0 23.2 0.0 0.0 2.7 0.0 1.0 0.1 10.2 160.8 0.0 0.0 19.8 15.6 73.9 6.9 0.2 0.0 0.2 4.1 0.0 0.0 185.3 252.2 1.8 2.8 0.1 138.8 17.4 CA13 "CAXIII, FLJ37995, MGC59868" ENSG00000185015 "Carbonic anhydrase 13" Q8N1Q1 8 85220587-85284073 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 14.6" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 33.3;Proximal enterocytes: 52.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HEL: 15.6;OE19: 30.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA024689, CAB025567" Enhanced Approved Nucleoplasm,Nucleoli,Vesicles NA NA 27000 "Cluster 46: Basophils - DNA binding" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 21: OE19 - Mitochondria" "Cluster 45: Enterocytes - Digestion" Nucleoli "Nucleoplasm, Vesicles" "CAB025567: , HPA024689: AB_1846004" "unprognostic (1.12e-2)" "unprognostic (2.20e-1)" "unprognostic (1.75e-1)" "unprognostic (9.16e-5)" "unprognostic (2.21e-2)" "unprognostic (2.08e-1)" "unprognostic (9.39e-2)" "unprognostic (7.90e-3)" "unprognostic (1.97e-1)" "unprognostic (1.34e-2)" "unprognostic (3.58e-2)" "unprognostic (3.13e-1)" "prognostic favorable (9.40e-4)" "unprognostic (7.59e-2)" "unprognostic (1.59e-1)" "unprognostic (1.55e-2)" "unprognostic (3.00e-1)" 1.8 2.1 1.2 1.2 1.2 0.3 2.3 1.4 1.3 2.1 0.7 2.5 12.0 0.9 0.6 5.0 1.1 5.4 3.6 1.0 1.7 5.7 3.7 2.4 0.6 0.9 1.5 1.1 1.1 9.0 2.9 0.3 0.8 1.2 3.0 2.3 4.8 0.7 0.4 5.6 14.6 0.8 0.6 0.7 5.9 0.7 1.1 0.7 5.0 0.3 2.9 2.1 2.5 1.3 0.2 0.4 0.8 0.1 0.5 0.6 0.4 1.0 1.1 0.1 2.9 7.2 5.4 0.4 0.5 1.2 6.0 2.3 2.2 2.9 0.2 1.6 0.9 15.6 2.0 6.7 1.4 0.2 0.6 2.2 0.5 0.2 1.2 1.8 1.6 0.6 4.0 2.9 2.6 0.0 0.3 0.2 0.4 30.6 0.4 0.2 2.2 0.1 8.1 0.3 0.2 0.0 0.5 0.0 1.6 1.0 0.5 0.8 1.5 2.8 3.9 0.1 1.6 1.1 0.6 1.9 5.7 2.2 2.6 0.7 0.6 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.1 0.1 0.0 0.2 0.2 0.0 0.2 1.2 1.2 1.4 1.3 1.0 1.7 0.9 1.5 0.8 0.6 1.1 1.3 1.7 3.2 12.4 7.2 2.9 1.8 2.7 2.7 3.4 1.8 7.0 4.7 6.4 4.3 10.5 12.9 33.3 0.3 2.1 12.3 9.8 4.0 11.3 4.7 2.5 2.7 4.8 3.2 12.2 1.6 0.3 2.9 9.7 7.7 0.0 0.3 8.6 5.8 1.1 0.0 13.7 4.3 2.0 2.5 3.3 13.1 0.0 3.0 5.4 1.9 1.0 1.9 8.2 16.1 4.4 4.4 4.3 0.0 6.9 1.9 52.6 21.0 9.5 5.1 0.0 8.1 1.9 1.3 2.1 9.1 3.1 0.3 2.2 1.0 5.4 2.4 CA14 ENSG00000118298 "Carbonic anhydrase 14" Q9ULX7 1 150257251-150265078 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 33.3;retina: 39.4;skeletal muscle: 33.7;tongue: 47.4" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 69.5;Melanocytes: 53.4;Muller glia cells: 164.5;Oligodendrocytes: 25.7" "Cancer enriched" "Detected in many" 5 "melanoma: 23.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "AF22: 102.2;AN3-CA: 65.9;NTERA-2: 83.9;SK-MEL-30: 217.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008482 Approved Approved "Plasma membrane" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 54: Non-specific - Microtubule organization" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 5: Muller glia cells - Visual perception" "Plasma membrane" "HPA008482: AB_1078395" "unprognostic (3.06e-2)" "unprognostic (1.67e-1)" "unprognostic (2.10e-2)" "unprognostic (3.25e-2)" "prognostic favorable (8.47e-4)" "unprognostic (7.28e-2)" "unprognostic (4.48e-2)" "unprognostic (1.49e-1)" "unprognostic (2.10e-1)" "unprognostic (2.47e-1)" "unprognostic (5.46e-2)" "unprognostic (1.73e-1)" "unprognostic (5.89e-3)" "unprognostic (1.91e-1)" "unprognostic (1.49e-1)" "unprognostic (1.22e-1)" "unprognostic (5.80e-2)" 0.0 0.2 8.6 0.2 14.4 1.2 0.3 15.9 27.6 0.1 33.3 3.8 0.4 0.1 0.4 1.9 1.7 0.6 7.6 8.7 11.3 0.3 8.7 0.2 0.1 14.3 14.0 1.4 0.2 3.4 0.5 0.3 14.6 4.0 0.7 39.4 0.4 20.3 33.7 5.4 1.3 0.5 12.5 0.2 1.2 0.5 13.3 0.0 1.0 47.4 0.0 0.6 0.1 20.6 0.9 0.2 102.2 65.9 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.6 0.7 0.1 0.5 0.0 0.1 0.3 0.2 0.1 0.0 0.2 1.1 0.3 0.3 6.9 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.6 0.0 0.8 0.1 0.6 0.0 0.9 0.3 0.3 83.9 0.4 1.1 0.1 0.3 0.3 0.0 0.2 3.2 1.8 0.0 0.3 217.9 14.6 0.8 0.4 0.1 0.1 0.2 0.2 0.4 0.9 4.9 0.4 0.7 0.5 0.2 0.0 0.2 0.4 0.4 0.5 0.1 0.5 0.2 0.3 0.0 0.6 0.3 0.3 0.5 0.0 0.1 0.6 0.0 0.0 8.6 14.4 15.9 27.6 8.7 11.3 14.3 14.0 14.6 12.5 13.3 20.6 0.1 3.2 0.5 0.3 0.2 2.2 0.3 0.3 0.0 1.3 0.1 0.0 69.5 0.0 0.7 0.0 0.0 0.4 0.0 0.3 0.0 0.8 0.0 0.3 0.1 0.6 0.0 0.0 0.1 0.7 0.1 3.4 0.0 0.2 0.0 0.0 0.0 6.1 0.1 0.0 0.1 0.3 0.0 0.3 0.9 0.2 0.9 0.1 53.4 0.0 0.0 164.5 0.0 0.0 25.7 1.9 0.3 3.4 0.0 0.3 0.0 0.1 0.1 4.9 0.0 0.6 0.5 0.0 0.2 0.0 0.4 0.3 0.1 0.0 0.2 0.5 CA2 "CA-II, CAII, Car2" ENSG00000104267 "Carbonic anhydrase 2" P00918 8 85463968-85481493 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Lyase "Disease variant, FDA approved drug targets, Osteopetrosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 687.4;stomach 1: 1108.7" "Cell type enhanced" "Detected in many" "Distal enterocytes: 1773.2;Erythroid cells: 2448.1;Gastric mucus-secreting cells: 1380.7;Muller glia cells: 1536.4;Paneth cells: 781.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 51.2" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HaCaT: 263.8;HEK 293: 1097.8;THP-1: 461.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001550, CAB010102" Enhanced NA Yes 570000000 "Cluster 38: Basophils - Unknown function" "Cluster 9: Intestine - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 6: Erythroid cells - Oxygen transport" "CAB010102: AB_626796, HPA001550: AB_1078393" "unprognostic (6.78e-2)" "unprognostic (3.06e-2)" "unprognostic (1.05e-2)" "unprognostic (1.63e-1)" "unprognostic (2.59e-1)" "unprognostic (9.24e-2)" "unprognostic (1.74e-1)" "unprognostic (1.72e-2)" "unprognostic (1.07e-1)" "unprognostic (5.23e-2)" "unprognostic (1.57e-1)" "unprognostic (9.89e-2)" "prognostic favorable (5.57e-6)" "unprognostic (2.45e-1)" "unprognostic (2.03e-1)" "unprognostic (1.32e-1)" "unprognostic (6.49e-3)" 7.4 10.1 95.9 36.8 127.5 246.8 37.9 122.1 143.8 5.0 444.0 687.4 285.2 2.9 10.6 19.8 2.7 112.7 15.9 105.2 107.8 331.2 273.5 43.1 6.6 115.5 112.0 0.4 55.1 10.1 6.1 19.6 114.2 1.9 643.6 390.4 74.7 68.4 42.7 81.0 31.3 32.3 98.2 8.4 1108.7 21.2 115.6 5.1 15.9 62.8 4.3 2.9 5.2 145.5 3.7 2.8 12.2 0.0 0.1 0.0 31.2 0.0 0.0 0.0 0.0 15.1 0.9 0.0 9.5 0.0 0.1 263.8 37.4 13.2 0.0 0.0 1097.8 35.8 17.0 0.5 0.0 23.7 5.1 0.0 63.9 0.0 3.7 0.0 0.0 0.0 0.3 0.2 0.0 0.4 0.4 41.4 3.7 86.5 0.0 21.2 1.3 0.5 3.7 8.8 0.2 0.3 5.0 0.0 0.1 9.6 0.0 461.5 0.0 0.0 6.6 0.0 0.4 0.4 1.0 0.1 1.8 0.1 0.0 51.2 5.3 8.6 0.2 15.0 7.4 1.3 0.1 0.8 15.4 3.0 0.0 0.0 12.6 0.1 13.4 1.4 0.0 33.3 95.9 127.5 122.1 143.8 105.2 107.8 115.5 112.0 114.2 98.2 115.6 145.5 19.4 16.0 79.9 34.0 19.6 90.6 1.3 152.5 17.6 23.1 56.9 18.4 19.8 430.4 22.4 161.8 64.6 15.2 2.4 1773.2 348.3 60.1 65.9 3.3 1.3 26.7 30.5 2448.1 1.4 11.3 403.1 6.4 1380.7 8.3 15.9 0.4 4.2 135.6 35.4 13.5 22.3 116.0 10.2 11.0 216.5 232.1 3.4 51.8 74.7 6.5 6.6 1536.4 1.0 3.0 226.4 16.1 781.9 2.2 10.3 3.5 0.3 468.2 3.9 66.1 0.0 12.1 8.2 3.1 2.8 31.2 111.7 17.1 11.7 0.7 390.8 0.5 CA3 "CAIII, Car3" ENSG00000164879 "Carbonic anhydrase 3" P07451 8 85373436-85449040 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "skeletal muscle: 5273.7" "Group enriched" "Detected in many" 8 "Erythroid cells: 221.3;Skeletal myocytes: 304.0" "Group enriched" "Detected in many" 7 "glioma: 23.1;prostate cancer: 9.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "HEL: 47.3;RH-30: 78.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "CAB004967, HPA021775, HPA026700" Enhanced NA NA 53000000 "Cluster 33: Striated muscle - Muscle contraction" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 37: Myocytes - Muscle contraction" "CAB004967: AB_437014, HPA021775: AB_1845990, HPA026700: AB_1845991" "prognostic favorable (4.24e-6)" "unprognostic (1.40e-1)" "unprognostic (1.50e-2)" "unprognostic (2.22e-3)" "unprognostic (4.71e-2)" "unprognostic (8.43e-3)" "unprognostic (3.56e-2)" "unprognostic (4.04e-2)" "unprognostic (1.11e-1)" "unprognostic (3.68e-1)" "unprognostic (4.71e-2)" "unprognostic (3.54e-1)" "unprognostic (3.19e-2)" "unprognostic (1.18e-1)" "unprognostic (9.96e-2)" "unprognostic (1.39e-1)" "unprognostic (2.19e-1)" 43.4 3.8 2.4 0.3 2.3 9.9 6.4 2.7 3.7 5.1 1.4 1.7 1.8 8.3 2.1 64.8 9.8 2.2 19.5 2.3 2.8 3.7 2.4 24.6 0.4 2.9 2.3 1.4 1.3 1.0 3.8 0.3 2.0 89.5 1.1 5.5 15.4 2.7 5273.7 5.2 4.4 19.1 2.5 0.8 4.1 2.9 2.5 1.4 3.0 1018.8 0.6 1.5 5.5 2.8 2.0 0.0 1.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.8 1.1 0.0 0.1 0.0 0.1 0.2 0.3 0.3 0.0 0.5 0.2 47.3 0.0 1.2 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 7.6 0.0 0.0 78.0 0.0 1.5 0.0 0.1 0.0 0.0 0.0 0.0 1.4 0.0 2.1 0.0 0.0 0.7 0.0 0.1 0.0 0.0 0.0 0.3 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 2.4 2.3 2.7 3.7 2.3 2.8 2.9 2.3 2.0 2.5 2.5 2.8 0.3 3.2 4.2 2.3 0.1 0.5 1.7 0.6 1.2 0.0 14.5 0.6 1.0 5.7 0.6 0.0 6.2 1.1 0.4 0.4 0.0 0.6 24.1 0.4 0.2 2.2 0.0 221.3 2.2 0.2 0.2 9.1 0.0 0.7 0.0 0.2 2.5 0.3 0.4 0.0 2.5 0.4 0.0 0.3 0.4 7.0 0.3 2.5 0.0 0.0 0.0 29.6 0.0 1.5 0.7 0.2 1.7 0.0 0.0 0.5 8.5 0.6 1.0 1.6 0.0 304.0 5.1 0.6 1.3 0.2 1.0 1.6 1.4 0.3 0.9 0.3 CA4 "CAIV, Car4, RP17" ENSG00000167434 "Carbonic anhydrase 4" P22748 17 60149942-60170899 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Lyase "Disease variant, FDA approved drug targets, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 263.6" "Group enriched" "Detected in many" 16 "Adipocytes: 704.2;Distal enterocytes: 1289.3;Paneth cells: 2368.3" "Cancer enhanced" "Detected in many" "colorectal cancer: 7.3" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 7 "neutrophil: 99.5" "Lineage enriched" "Detected in single" 995 "granulocytes: 99.5" "Cell line enhanced" "Detected in single" "OE19: 1.1" "Region enriched" "Detected in all" 5 "cerebellum: 300.3" "Low region specificity" "Detected in all" "HPA011089, HPA017258" Enhanced Uncertain Vesicles,Cytosol NA NA 190000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 37: Intestine - Unknown function" "Cluster 5: NTERA-2 - Transcription" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol Vesicles "HPA011089: AB_1845996, HPA017258: AB_1845997" "unprognostic (2.07e-2)" "unprognostic (7.85e-2)" "unprognostic (1.55e-2)" "unprognostic (7.78e-3)" "unprognostic (8.42e-2)" "unprognostic (1.19e-1)" "unprognostic (3.19e-2)" "unprognostic (5.84e-2)" "unprognostic (7.76e-2)" "unprognostic (9.74e-2)" "unprognostic (1.54e-1)" "unprognostic (1.71e-2)" "unprognostic (2.68e-3)" "unprognostic (8.59e-2)" "unprognostic (1.43e-1)" "unprognostic (2.45e-1)" "unprognostic (4.57e-2)" 83.0 2.3 17.8 3.1 18.8 19.5 80.9 86.8 34.2 12.7 13.9 263.6 3.8 6.0 51.9 1.0 5.0 38.3 55.2 22.8 13.9 47.6 0.7 87.2 0.6 13.4 17.8 6.2 31.8 16.9 15.7 8.6 22.8 8.2 172.6 0.1 10.4 36.9 30.5 3.8 11.2 2.7 12.7 16.0 10.0 1.3 15.1 1.6 74.6 42.3 0.1 6.2 5.6 14.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 1.1 0.0 0.0 0.0 0.3 0.5 0.0 0.2 0.0 0.0 0.0 0.0 0.7 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 99.5 0.0 0.0 0.0 0.0 0.1 17.8 18.8 86.8 34.2 22.8 13.9 13.4 17.8 22.8 12.7 15.1 14.9 704.2 0.0 2.4 1.3 1.5 1.5 0.3 0.0 2.2 0.0 2.3 2.5 9.1 0.0 0.6 14.7 0.0 0.0 1.2 1289.3 33.2 11.7 0.5 0.6 13.0 88.3 19.3 0.0 3.8 0.2 0.0 4.4 0.0 0.2 11.4 23.2 1.4 0.0 0.6 0.0 1.4 24.6 0.0 0.0 1.2 0.1 0.6 1.1 0.0 23.4 0.0 0.1 0.0 1.0 0.4 0.1 2368.3 0.0 1.2 0.1 14.9 72.4 0.7 0.0 6.6 5.0 23.4 0.1 0.0 0.1 1.1 0.0 2.4 0.4 41.7 0.3 CA5A "CA5, CAV, CAVA" ENSG00000174990 "Carbonic anhydrase 5A" P35218 16 87881546-87936580 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" Lyase "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 30 "liver: 24.2" "Cell type enriched" "Detected in many" 6 "Hepatocytes: 39.0" "Cancer enriched" "Detected in single" 26 "liver cancer: 2.0" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 36 "Hep G2: 25.5" "Not detected" "Not detected" "Low region specificity" "Detected in all" NA NA "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 15: Hepatocytes - Hemostasis" "unprognostic (1.91e-1)" "unprognostic (8.64e-3)" "unprognostic (3.36e-2)" "unprognostic (6.11e-2)" "unprognostic (2.49e-2)" "unprognostic (2.96e-1)" "unprognostic (8.39e-3)" "unprognostic (3.50e-3)" "unprognostic (1.42e-2)" "unprognostic (1.12e-1)" "unprognostic (6.55e-2)" "unprognostic (4.23e-2)" "unprognostic (7.99e-3)" "unprognostic (1.77e-1)" "unprognostic (5.03e-3)" "unprognostic (3.37e-2)" "unprognostic (2.76e-2)" 0.0 0.0 0.5 0.1 0.5 0.1 0.1 0.6 0.8 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.5 0.0 24.2 0.1 0.1 0.6 0.5 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.1 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 25.5 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.5 0.6 0.8 0.5 0.5 0.6 0.5 0.6 0.5 0.5 0.5 0.2 0.0 3.4 0.3 0.3 0.4 2.5 0.0 0.0 1.7 0.2 0.3 2.1 0.0 1.3 1.8 4.2 0.4 0.5 0.1 0.0 0.0 0.3 0.6 0.4 5.4 0.0 2.7 0.8 0.0 0.3 1.0 0.0 0.8 6.3 0.2 1.1 39.0 0.1 3.3 0.6 0.2 0.0 1.4 1.6 0.8 0.3 1.5 0.0 2.8 0.2 0.8 2.1 0.0 0.5 0.0 0.0 1.2 0.1 1.9 0.2 0.3 1.5 3.8 0.0 4.1 1.1 0.4 0.4 0.0 0.3 0.3 1.2 1.7 0.1 1.8 CA5B ENSG00000169239 "Carbonic anhydrase 5B" Q9Y2D0 X 15688830-15788411 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "dendritic cells: 37.9;Muller glia cells: 35.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC TERT1: 22.3;fHDF/TERT166: 27.0;hTERT-HME1: 34.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA012618 Uncertain Supported Mitochondria NA NA "Cluster 20: T-cells - T-cell receptor" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 30: Epithelial cell lines - Translation" "Cluster 24: Non-specific - Transcription regulation" Mitochondria "HPA012618: AB_1846000" "unprognostic (1.62e-2)" "unprognostic (2.10e-3)" "unprognostic (2.86e-1)" "unprognostic (1.55e-3)" "unprognostic (1.16e-2)" "unprognostic (4.59e-5)" "unprognostic (2.50e-1)" "unprognostic (6.89e-4)" "unprognostic (4.11e-1)" "unprognostic (3.89e-3)" "unprognostic (1.54e-1)" "unprognostic (1.17e-1)" "prognostic favorable (6.66e-6)" "unprognostic (2.43e-1)" "unprognostic (1.38e-1)" "unprognostic (8.94e-2)" "unprognostic (3.08e-1)" 5.9 3.1 5.3 4.2 5.8 3.5 8.3 3.9 5.4 21.5 5.8 2.8 1.6 7.3 2.6 6.5 7.5 7.3 4.0 3.9 7.3 4.8 2.1 6.0 5.6 8.4 6.5 11.9 3.4 9.1 2.4 3.1 6.9 4.8 3.6 10.5 4.5 4.6 1.6 5.7 2.6 7.6 6.3 4.3 4.4 10.3 6.1 4.3 7.2 5.4 6.8 5.2 5.5 4.6 4.3 2.6 2.9 4.8 8.5 22.3 1.7 4.4 5.6 3.2 4.6 1.3 2.8 1.2 4.5 27.0 6.1 4.6 10.3 5.0 5.7 1.2 4.8 2.3 3.3 1.1 8.3 3.0 5.0 5.3 5.3 4.3 34.2 5.7 4.8 3.5 1.2 3.0 15.4 2.3 2.5 2.3 1.2 0.8 18.6 1.4 2.1 2.2 4.9 3.1 2.6 5.3 6.1 2.2 3.8 3.4 3.1 3.0 6.5 3.8 2.5 20.4 2.5 2.2 2.4 1.4 4.2 6.0 7.2 4.4 3.9 0.4 16.7 4.8 14.5 4.6 16.6 15.5 4.7 5.0 12.1 10.4 2.2 11.0 3.1 0.7 14.3 10.0 5.3 5.8 3.9 5.4 3.9 7.3 8.4 6.5 6.9 6.3 6.1 4.6 9.6 0.0 7.9 14.0 19.1 4.2 6.3 3.4 6.2 9.5 7.3 5.2 2.4 0.0 7.1 1.8 16.7 1.8 37.9 1.6 1.9 4.4 1.1 9.6 7.1 13.9 3.0 11.2 11.5 4.0 1.8 10.5 11.7 6.2 2.5 6.7 6.1 2.7 1.9 1.7 11.8 2.2 8.2 9.3 11.1 1.8 7.8 10.8 3.6 19.7 9.1 35.9 32.0 8.5 10.6 4.1 1.6 5.3 18.7 11.5 1.2 2.9 12.2 7.8 6.6 8.1 8.3 4.2 5.6 5.5 4.5 1.9 30.0 12.1 1.5 7.9 CA6 ENSG00000131686 "Carbonic anhydrase 6" P23280 1 8945867-8975092 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted secreted proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 295 "salivary gland: 9393.1" "Group enriched" "Detected in some" 44 "Breast glandular cells: 77.9;Ionocytes: 99.7;Melanocytes: 179.7" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in single" "Group enriched" "Detected in some" 4 "naive CD4 T-cell: 5.6;naive CD8 T-cell: 16.4" "Lineage enriched" "Detected in many" 11 "T-cells: 16.4" "Cell line enhanced" "Detected in some" "Daudi: 1.7;U-2197: 1.3" "Not detected" "Not detected" "Low region specificity" "Detected in some" "HPA028550, HPA028692" Enhanced "Secreted to digestive system" NA NA 24000000 "Cluster 32: T-cells - Unknown function" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 30: Mammary glandular cells - Lactation" "HPA028550: AB_10600105, HPA028692: AB_10601883" "unprognostic (2.54e-5)" "unprognostic (1.09e-1)" "unprognostic (1.10e-1)" "unprognostic (2.37e-1)" "unprognostic (2.90e-1)" "unprognostic (9.28e-2)" "unprognostic (2.70e-3)" "unprognostic (1.24e-1)" "unprognostic (1.73e-1)" "unprognostic (5.93e-2)" "unprognostic (4.41e-2)" "unprognostic (4.29e-5)" "unprognostic (1.14e-1)" "unprognostic (1.31e-1)" "unprognostic (2.35e-1)" 0.4 0.4 0.3 0.7 0.6 2.0 20.8 0.9 0.7 0.0 0.5 0.1 0.3 0.2 2.3 0.2 0.1 0.2 1.5 0.4 0.3 0.1 0.1 0.3 1.3 0.9 0.4 1.9 6.3 0.0 0.1 0.9 0.7 0.2 0.2 0.7 9393.1 0.0 0.4 31.8 0.5 0.0 0.1 1.2 0.4 0.3 0.7 1.2 0.3 0.0 1.0 0.1 0.0 1.8 0.2 0.0 0.2 0.4 0.1 0.0 0.3 0.1 0.0 0.0 0.2 0.3 0.4 1.7 0.1 0.1 0.4 0.3 0.1 0.0 0.2 0.2 0.2 0.2 0.6 0.2 0.0 0.5 0.5 0.0 0.1 0.2 0.0 0.2 0.2 0.3 0.2 0.4 0.0 0.2 0.2 0.4 0.3 0.2 0.1 0.3 0.1 0.0 0.0 0.3 0.2 0.1 0.0 0.2 0.1 0.1 0.4 0.2 0.1 0.6 0.3 1.3 0.2 0.4 0.1 0.4 0.1 0.4 0.4 1.4 0.3 0.2 0.3 0.2 0.3 0.3 0.7 2.7 0.0 0.5 5.6 16.4 1.3 0.4 0.2 0.3 0.3 1.6 0.3 0.6 0.9 0.7 0.4 0.3 0.9 0.4 0.7 0.1 0.7 1.8 0.2 0.0 0.0 0.0 0.1 0.1 0.1 1.4 0.0 0.0 77.9 2.7 0.3 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 99.7 0.0 1.3 0.2 0.0 0.2 179.7 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.1 0.0 0.1 0.0 0.6 0.5 0.0 0.0 CA7 ENSG00000168748 "Carbonic anhydrase 7" P43166 16 66844414-66854153 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "intestine: 57.0" "Cell type enriched" "Detected in some" 40 "Paneth cells: 3026.3" "Cancer enhanced" "Detected in some" "colorectal cancer: 0.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "REH: 1.1;THP-1: 1.9" "Region enhanced" "Detected in all" "cerebellum: 67.2" "Low region specificity" "Detected in many" HPA047237 Uncertain NA NA "Cluster 37: Intestine - Unknown function" "Cluster 43: THP-1 - Innate immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA047237: AB_2679994" "unprognostic (8.77e-4)" "unprognostic (5.23e-4)" "unprognostic (1.57e-1)" "unprognostic (1.96e-2)" "unprognostic (2.19e-1)" "unprognostic (2.16e-2)" "unprognostic (7.90e-2)" "unprognostic (1.59e-1)" "unprognostic (1.84e-2)" "unprognostic (9.62e-2)" "unprognostic (1.69e-2)" "unprognostic (7.12e-3)" "unprognostic (8.47e-2)" "unprognostic (5.20e-1)" "unprognostic (1.90e-2)" "unprognostic (6.46e-2)" 0.0 0.0 5.1 0.2 6.7 0.0 0.1 4.8 10.7 0.0 2.1 57.0 6.9 0.1 0.9 0.1 0.0 0.0 0.0 8.0 3.1 0.0 0.0 0.0 0.0 3.8 3.5 0.0 0.0 0.0 0.1 0.0 3.5 0.0 48.6 0.0 0.0 0.2 0.0 0.0 10.0 1.1 2.6 0.0 0.0 0.5 4.7 0.1 0.0 0.2 0.0 0.0 0.0 5.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.3 1.1 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.1 6.7 4.8 10.7 8.0 3.1 3.8 3.5 3.5 2.6 4.7 5.6 0.0 0.0 0.0 0.7 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 74.2 0.0 0.0 0.0 0.0 0.0 0.0 16.3 0.0 9.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 4.1 16.9 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 3026.3 0.0 0.0 0.5 23.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.3 0.0 39.9 0.1 CA8 "CALS, CARP" ENSG00000178538 "Carbonic anhydrase 8" P35219 8 60185412-60281400 "Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 18.3;parathyroid gland: 40.1" "Cell type enhanced" "Detected in many" "Astrocytes: 92.7;Enteroendocrine cells: 35.2;Gastric mucus-secreting cells: 40.2;Oligodendrocyte precursor cells: 129.7" "Cancer enhanced" "Detected in many" "endometrial cancer: 7.8" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 24 "basophil: 76.2" "Lineage enriched" "Detected in many" 24 "granulocytes: 76.2" "Cell line enhanced" "Detected in some" "HEK 293: 10.1;JURKAT: 11.0;K-562: 20.3;NB-4: 12.3;OE19: 17.4" "Region enriched" "Detected in all" 38 "cerebellum: 1260.5" "Region enriched" "Detected in all" 9 "cerebellum: 86.3" "HPA024748, CAB025545, CAB047309" Enhanced NA NA "Cluster 38: Basophils - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 1: K-562 - Erythropoiesis" "Cluster 68: Oligodendrocytes - Mixed function" "CAB025545: , CAB047309: , HPA024748: AB_1846003" "unprognostic (1.55e-1)" "unprognostic (2.89e-2)" "unprognostic (4.43e-2)" "unprognostic (3.46e-3)" "unprognostic (6.67e-2)" "unprognostic (3.19e-1)" "unprognostic (3.85e-2)" "unprognostic (3.54e-2)" "unprognostic (1.28e-1)" "unprognostic (1.19e-1)" "prognostic favorable (5.79e-5)" "unprognostic (3.23e-2)" "unprognostic (1.68e-2)" "unprognostic (2.12e-1)" "unprognostic (1.71e-2)" "unprognostic (1.95e-1)" "unprognostic (1.41e-1)" 1.6 0.9 5.2 0.3 5.8 0.5 4.6 18.3 5.6 4.3 2.0 1.3 1.0 1.9 10.2 0.2 1.5 0.3 4.3 4.4 5.3 5.3 0.0 0.9 0.4 4.7 4.9 0.2 1.9 40.1 8.5 6.2 5.0 1.5 2.0 2.3 3.7 0.2 1.2 0.3 1.0 0.5 3.1 0.8 4.4 4.1 5.1 1.3 0.3 2.3 0.3 0.6 0.3 4.0 0.0 2.4 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.6 0.0 0.0 0.0 1.1 0.0 0.1 0.0 10.1 4.5 0.0 0.0 3.6 1.8 1.2 0.0 0.0 0.0 0.0 0.0 0.0 11.0 20.3 0.2 0.0 0.0 3.3 12.3 0.2 17.4 0.0 0.0 0.0 0.2 0.4 0.8 5.1 0.0 0.0 1.1 0.0 2.0 4.5 0.7 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 5.5 76.2 0.0 0.5 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 3.1 0.0 0.1 5.2 5.8 18.3 5.6 4.4 5.3 4.7 4.9 5.0 3.1 5.1 4.0 22.0 0.0 4.8 92.7 1.6 1.0 0.4 4.1 0.0 8.2 15.6 10.3 4.7 0.0 5.7 3.7 0.0 8.3 10.9 2.0 3.9 8.1 9.9 9.8 2.4 16.7 35.2 13.5 4.7 6.0 0.3 4.0 40.2 26.2 0.0 1.1 0.0 0.0 9.9 0.0 25.6 25.0 6.1 1.9 1.1 4.9 1.5 1.1 7.2 18.7 0.0 2.6 1.0 129.7 0.4 1.6 3.5 1.5 14.0 2.1 0.3 0.0 1.2 1.0 0.0 0.8 2.3 3.8 5.5 0.2 0.4 1.4 0.7 3.1 3.3 1.5 CA9 "CAIX, MN" ENSG00000107159 "Carbonic anhydrase 9" Q16790 9 35673918-35681159 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 12 "stomach 1: 289.3" "Cell type enhanced" "Detected in some" "Basal respiratory cells: 275.3;Cholangiocytes: 62.9;Early spermatids: 205.8;Gastric mucus-secreting cells: 259.5" "Cancer enhanced" "Detected in many" "renal cancer: 85.9" "Region enriched" "Detected in single" 9 "cerebellum: 5.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 10 "A-431: 189.3;HDLM-2: 98.1;hTERT-RPE1: 113.1;U-87 MG: 374.4" "Region enhanced" "Detected in many" "cerebellum: 12.3" "Low region specificity" "Detected in all" "CAB005100, CAB017107, HPA055207" Enhanced Supported "Plasma membrane" "Intracellular and membrane" NA NA "Cluster 4: Stomach - Digestion" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Plasma membrane" "CAB005100: AB_2066539, CAB017107: , HPA055207: AB_2682738" "unprognostic (8.01e-3)" "unprognostic (1.34e-2)" "unprognostic (2.28e-1)" "unprognostic (2.00e-2)" "unprognostic (1.59e-2)" "unprognostic (1.15e-1)" "prognostic unfavorable (1.71e-5)" "unprognostic (1.47e-2)" "unprognostic (3.90e-2)" "unprognostic (1.29e-1)" "unprognostic (6.24e-3)" "unprognostic (1.13e-1)" "prognostic unfavorable (2.22e-7)" "unprognostic (7.29e-2)" "prognostic favorable (9.50e-4)" "unprognostic (2.97e-3)" "unprognostic (8.67e-2)" 3.8 0.4 0.0 0.2 0.0 0.0 0.1 5.6 0.6 0.5 0.0 0.6 14.5 0.2 0.1 0.8 0.4 24.4 2.0 0.2 0.1 0.2 1.3 0.2 0.0 0.0 0.1 0.7 6.6 0.0 0.5 0.0 0.2 0.5 0.0 1.0 0.1 0.1 0.1 8.2 13.6 0.1 0.0 0.0 289.3 5.5 0.5 0.0 0.0 0.0 0.0 0.7 0.7 0.0 189.3 0.3 0.0 0.0 0.0 0.0 0.0 0.2 3.6 0.3 2.5 0.0 0.1 0.0 0.1 0.0 0.5 5.7 0.0 0.9 1.5 98.1 0.0 0.0 0.7 0.4 0.0 0.0 0.2 0.4 0.0 0.0 0.3 113.1 0.1 0.0 0.0 0.3 0.1 0.0 0.0 0.1 0.3 0.2 0.5 0.0 0.0 10.6 0.0 0.6 1.6 0.0 0.0 0.1 0.7 0.0 0.0 0.2 0.0 18.9 0.4 0.0 4.7 0.0 0.4 0.1 374.4 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 5.6 0.6 0.2 0.1 0.0 0.1 0.2 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.2 4.5 0.7 275.3 0.0 0.4 0.1 0.0 0.4 62.9 28.1 0.0 0.0 0.0 0.0 0.1 0.0 49.1 205.8 0.0 0.1 0.2 0.0 0.0 0.1 50.9 0.6 1.2 259.5 0.2 0.0 0.4 0.7 0.0 0.1 0.0 0.6 4.0 18.3 0.0 0.0 19.6 1.5 0.1 0.0 0.0 0.6 1.3 0.0 0.0 0.0 26.6 0.0 0.7 0.3 0.8 0.7 0.1 5.5 0.0 0.0 0.0 1.5 0.9 4.0 0.0 3.1 0.3 0.1 0.7 5.3 0.4 CAT ENSG00000121691 Catalase P04040 11 34438934-34472060 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrogen peroxide" "Mitogen, Oxidoreductase, Peroxidase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 1217.3" "Cell type enhanced" "Detected in many" "Erythroid cells: 722.4;Hepatocytes: 443.4;Proximal tubular cells: 333.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 13 "eosinophil: 4736.8" "Lineage enriched" "Detected in all" 13 "granulocytes: 4736.8" "Cell line enhanced" "Detected in many" "HL-60: 391.4;THP-1: 321.2;U-937: 265.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001515, HPA051282, HPA055838" Enhanced Enhanced Vesicles NA NA 760000000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 85: Liver - Metabolism" "Cluster 32: U-937 - Innate immune response" "Cluster 6: Erythroid cells - Oxygen transport" Vesicles "CAB001515: AB_384710, HPA051282: AB_2681419, HPA055838: AB_2682937" "unprognostic (3.62e-2)" "unprognostic (2.72e-1)" "unprognostic (3.59e-3)" "unprognostic (5.43e-2)" "unprognostic (4.44e-2)" "unprognostic (5.80e-3)" "prognostic favorable (9.67e-4)" "unprognostic (9.95e-3)" "unprognostic (3.22e-1)" "unprognostic (7.23e-2)" "unprognostic (3.34e-2)" "unprognostic (9.77e-2)" "prognostic favorable (1.96e-8)" "unprognostic (1.01e-1)" "unprognostic (7.31e-2)" "unprognostic (4.77e-2)" "unprognostic (6.59e-3)" 281.3 115.1 27.1 52.1 29.6 407.7 123.6 27.9 35.5 82.0 39.4 82.6 145.1 53.1 34.8 40.1 86.8 59.8 58.1 26.6 29.4 296.6 1217.3 163.2 58.4 35.2 29.4 46.7 86.3 43.2 13.6 78.0 34.3 66.8 71.3 9.8 83.7 64.0 103.8 70.6 136.3 59.4 29.6 78.6 74.1 11.4 29.5 74.9 122.6 136.6 56.7 105.8 39.9 40.8 31.7 34.3 24.5 38.9 233.2 100.6 52.3 39.3 49.8 43.3 47.1 19.7 30.9 78.3 37.5 79.2 63.9 73.9 42.3 42.9 47.3 68.8 38.8 65.6 34.0 113.7 27.6 391.4 31.1 54.5 29.3 13.2 5.1 59.9 53.2 46.2 139.3 31.3 55.1 30.2 81.1 77.4 0.1 148.7 82.6 56.5 117.9 64.9 120.2 117.2 13.1 19.8 44.5 70.6 60.0 0.0 101.4 321.2 38.3 25.9 24.9 65.4 23.8 25.0 15.2 16.8 51.3 265.6 19.3 256.5 324.7 4736.8 54.4 265.1 64.6 133.9 63.7 61.0 353.5 124.1 61.7 66.7 290.2 105.7 298.5 235.8 92.7 397.9 27.1 29.6 27.9 35.5 26.6 29.4 35.2 29.4 34.3 29.6 29.5 40.8 196.9 227.6 275.9 41.1 53.8 28.9 93.7 44.9 27.9 13.5 42.6 36.1 44.9 82.9 66.9 73.5 27.1 96.8 92.0 59.4 225.0 36.0 2.7 72.2 41.4 43.8 48.0 722.4 12.6 26.2 30.0 53.1 54.6 29.3 24.0 38.7 57.1 443.4 138.5 0.0 1.2 56.9 91.6 125.5 95.8 6.2 78.3 93.9 26.6 16.9 253.4 19.5 28.8 22.6 45.6 15.3 44.8 77.5 25.4 37.0 151.6 333.2 96.9 19.4 78.9 46.6 68.0 6.3 11.3 24.4 27.1 40.5 37.7 57.7 95.6 97.5 CMA1 ENSG00000092009 "Chymase 1" P23946 14 24505353-24508265 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "breast: 18.5" "Cell type enriched" "Detected in some" 28 "granulocytes: 53.8" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB000363, HPA052634" Enhanced Supported "Cytosol,Cytoplasmic bodies" "Secreted to blood" NA NA 3000000 "Cluster 35: T-regs - Unknown function" "Cluster 46: Fibroblasts - ECM organization" "Cluster 60: Granulocytes - Receptor signaling" "Cytoplasmic bodies" Cytosol "CAB000363: AB_2083616, HPA052634: AB_2681892" "unprognostic (1.37e-1)" "unprognostic (2.27e-3)" "unprognostic (2.04e-1)" "unprognostic (7.07e-3)" "unprognostic (1.48e-2)" "unprognostic (1.19e-1)" "unprognostic (5.79e-2)" "unprognostic (2.21e-1)" "unprognostic (8.91e-3)" "unprognostic (4.19e-3)" "unprognostic (1.29e-4)" "unprognostic (2.52e-3)" "unprognostic (7.78e-2)" "unprognostic (7.37e-2)" "unprognostic (4.98e-3)" 9.0 0.0 0.2 3.7 0.1 0.2 18.5 0.0 0.2 4.6 0.3 8.7 0.6 3.1 4.3 10.2 0.9 7.3 1.6 0.1 0.2 0.2 0.5 1.5 1.8 0.5 0.3 0.1 1.6 0.6 0.2 0.1 0.3 1.0 8.3 0.0 4.7 1.3 0.9 9.0 5.8 2.2 0.3 0.2 1.5 0.9 0.2 3.0 0.4 3.0 2.4 11.1 0.9 0.2 0.0 0.0 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.2 0.2 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.5 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.1 0.0 0.2 0.1 0.2 0.5 0.3 0.3 0.3 0.2 0.2 0.0 0.0 1.9 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 53.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.1 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.4 0.0 0.7 0.0 0.1 0.0 CNP ENSG00000173786 "2',3'-cyclic nucleotide 3' phosphodiesterase" P09543 17 41966763-41977740 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, RNA-binding" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 7 "brain: 1395.7" "Cell type enriched" "Detected in all" 4 "Oligodendrocytes: 555.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "plasmacytoid DC: 149.4" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Region enriched" "Detected in all" 4 "white matter: 1789.4" "Low region specificity" "Detected in all" "CAB002672, HPA023266, HPA023278, HPA023280, HPA023338" Enhanced Supported Supported "Plasma membrane" NA NA 46000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 17: WM-115 - Nervous system development" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Plasma membrane" "CAB002672: , HPA023266: AB_1847058, HPA023278: AB_1847060, HPA023280: AB_1847061, HPA023338: AB_1847062" "unprognostic (2.17e-1)" "unprognostic (4.48e-2)" "unprognostic (3.85e-3)" "unprognostic (1.41e-1)" "unprognostic (3.09e-1)" "unprognostic (9.71e-2)" "unprognostic (2.58e-3)" "unprognostic (2.08e-1)" "unprognostic (2.23e-1)" "unprognostic (1.62e-1)" "unprognostic (5.76e-3)" "unprognostic (1.87e-1)" "unprognostic (2.99e-3)" "unprognostic (1.60e-1)" "unprognostic (1.55e-1)" "unprognostic (8.86e-2)" "unprognostic (1.10e-3)" 34.4 33.5 493.1 31.2 889.6 23.4 29.6 715.5 681.5 41.7 193.5 56.9 21.4 33.5 36.7 63.4 28.9 32.6 25.3 505.1 577.0 58.1 44.8 21.7 35.7 839.4 761.8 32.2 27.8 23.7 28.1 23.5 793.8 41.5 18.4 20.5 47.2 37.2 26.3 34.3 31.4 30.3 644.6 25.8 29.8 16.7 791.1 31.2 24.7 22.2 35.1 37.3 40.5 1395.7 56.9 92.4 85.8 106.6 71.7 67.2 38.5 70.1 102.5 171.1 191.5 73.0 49.6 59.0 54.3 88.5 88.1 95.0 58.3 44.6 59.0 59.7 76.8 56.7 59.3 127.7 76.9 56.7 49.6 111.0 31.5 94.1 22.8 61.9 79.4 58.0 42.4 46.4 60.6 35.1 148.5 50.9 20.7 29.8 66.5 91.4 126.7 58.7 45.7 55.7 50.9 69.5 85.7 127.0 155.5 41.6 57.2 82.3 80.2 66.6 73.7 92.3 81.9 53.4 66.6 47.5 66.1 42.9 266.4 18.7 38.2 23.4 21.5 40.7 17.2 28.0 18.8 17.4 33.8 19.2 16.6 19.6 7.7 23.5 34.0 149.4 22.4 33.0 493.1 889.6 715.5 681.5 505.1 577.0 839.4 761.8 793.8 644.6 791.1 1395.7 26.6 16.0 12.7 14.4 19.0 16.7 17.5 10.4 16.5 22.0 29.5 24.0 13.0 20.0 19.5 35.0 6.2 30.6 53.2 39.9 125.2 46.3 1.3 19.1 27.1 24.8 19.7 25.2 6.8 41.7 50.2 27.7 17.9 21.3 9.5 20.2 20.3 32.3 39.8 50.5 9.5 16.2 18.3 17.0 14.5 4.0 38.8 20.3 55.2 14.0 25.0 84.7 23.7 45.2 555.6 35.5 19.0 36.1 27.8 21.7 19.0 80.5 12.8 25.4 32.9 36.6 29.4 5.1 16.0 30.9 18.9 13.0 16.9 33.3 20.6 17.4 CPA1 CPA ENSG00000091704 "Carboxypeptidase A1" P15085 7 130380339-130388114 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 2326 "pancreas: 237498.3" "Cell type enriched" "Detected in some" 19 "Exocrine glandular cells: 10133.0" "Cancer enriched" "Detected in some" 639 "pancreatic cancer: 1377.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "AN3-CA: 11.8" "Not detected" "Not detected" "Low region specificity" "Detected in some" "HPA021836, CAB025197, HPA052215" Enhanced "Secreted to digestive system" NA NA 110000000 "Cluster 25: Pancreas - Digestion" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 1: Pancreatic cells - Digestion" "CAB025197: , HPA021836: AB_1846005, HPA052215: AB_2681764" "unprognostic (8.41e-2)" "unprognostic (9.24e-4)" "unprognostic (5.22e-2)" "unprognostic (1.76e-1)" "unprognostic (3.97e-1)" "unprognostic (1.76e-1)" "unprognostic (2.27e-1)" "unprognostic (1.15e-2)" "unprognostic (1.35e-1)" "unprognostic (1.34e-6)" "unprognostic (4.99e-1)" "unprognostic (1.67e-1)" "unprognostic (2.16e-1)" "unprognostic (4.37e-2)" 27.9 4.8 0.2 5.6 0.2 4.7 13.6 0.1 0.2 11.9 1.2 4.5 33.6 5.0 0.1 6.9 3.7 0.2 43.5 0.2 0.3 4.6 12.9 3.3 8.7 0.1 0.1 102.1 237498.3 0.0 5.0 18.4 0.1 6.9 0.0 0.2 39.5 0.1 4.7 6.6 20.8 0.4 0.2 7.7 21.3 5.4 0.2 0.1 3.0 0.4 0.0 2.8 4.0 0.4 0.0 0.0 0.0 11.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.4 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 2.1 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 1.7 0.0 0.2 0.0 1.5 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.1 0.2 0.2 0.3 0.1 0.1 0.1 0.2 0.2 0.4 0.1 3.2 0.0 0.3 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.9 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.0 5.9 12.0 1.9 0.0 0.1 0.1 0.0 0.0 0.0 10133.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 7.6 0.9 1.2 0.0 1.0 44.5 2.1 0.0 0.0 0.0 527.2 0.0 0.7 0.0 0.4 0.0 0.0 0.0 0.1 0.0 16.2 2.7 0.9 5.5 0.0 0.0 1.6 0.0 2.5 0.0 0.1 CPA2 ENSG00000158516 "Carboxypeptidase A2" P48052 7 130266863-130289798 "Enzymes, Metabolic proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 416 "pancreas: 45360.2" "Cell type enriched" "Detected in some" 10 "Exocrine glandular cells: 4973.8" "Cancer enriched" "Detected in many" 60 "pancreatic cancer: 411.4" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AN3-CA: 2.2;CACO-2: 3.8;RH-30: 3.0;SCLC-21H: 1.6" "Low region specificity" "Detected in all" "Not detected" "Not detected" "HPA020342, HPA021317" Enhanced Approved "Golgi apparatus" "Secreted to digestive system" NA NA 1500000 "Cluster 25: Pancreas - Digestion" "Cluster 39: CACO-2 - Unknown function" "Cluster 1: Pancreatic cells - Digestion" "Golgi apparatus" "HPA020342: AB_1846007, HPA021317: AB_1846008" "unprognostic (1.12e-1)" "unprognostic (3.97e-1)" "unprognostic (4.21e-2)" "unprognostic (1.82e-2)" "unprognostic (1.38e-1)" "unprognostic (6.76e-2)" "unprognostic (4.65e-2)" "unprognostic (1.08e-1)" "unprognostic (1.40e-1)" "unprognostic (1.84e-1)" "unprognostic (2.66e-1)" "unprognostic (3.84e-5)" "unprognostic (7.52e-2)" "unprognostic (1.42e-1)" "unprognostic (7.12e-2)" "unprognostic (8.48e-2)" 5.5 1.0 0.3 0.7 0.8 0.4 2.6 1.0 0.9 1.9 0.2 1.3 17.4 0.8 0.1 1.5 0.7 0.0 8.4 0.3 0.6 0.9 2.6 0.7 1.4 2.8 1.3 19.7 45360.2 0.0 1.4 3.2 2.5 1.5 0.4 0.8 7.8 0.0 0.8 1.1 30.6 0.0 1.2 1.2 108.9 2.2 1.1 0.1 0.6 0.0 0.0 0.5 0.8 3.1 0.0 0.0 0.4 2.2 0.0 0.0 0.0 0.0 0.0 0.3 0.0 3.8 0.0 0.0 0.5 0.0 0.3 0.0 0.7 0.0 0.0 0.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.2 0.0 3.0 0.0 0.0 0.3 1.6 0.0 0.1 0.0 1.0 0.1 0.0 0.1 0.0 0.0 0.6 0.4 0.3 0.0 0.4 0.1 0.4 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.8 1.0 0.9 0.3 0.6 2.8 1.3 2.5 1.2 1.1 3.1 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.3 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.6 1.9 8.1 4.3 0.0 0.0 0.9 0.0 0.0 0.1 4973.8 0.0 0.2 4.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.5 0.0 0.0 0.0 10.5 0.3 0.5 0.0 0.0 13.9 4.6 0.0 0.5 1.0 471.3 52.9 0.0 0.0 0.0 9.9 0.0 0.0 0.3 0.0 0.0 1.3 0.4 2.0 0.0 0.1 0.3 0.0 0.2 1.5 0.2 CPA5 ENSG00000158525 "Carboxypeptidase A5" Q8WXQ8 7 130344816-130368730 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 15 "testis: 33.6" "Group enriched" "Detected in some" 23 "Early spermatids: 76.1;Late spermatids: 144.1" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Group enriched" "Detected in some" 4 "memory CD4 T-cell: 16.8;naive CD8 T-cell: 42.5;T-reg: 56.4" "Lineage enriched" "Detected in single" 102 "T-cells: 56.4" "Cell line enhanced" "Detected in some" "RH-30: 7.3;RT4: 3.4;U-266/84: 6.0" "Not detected" "Not detected" HPA020322 Approved Nucleoplasm "Secreted in male reproductive system" NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 83: Testis - Spermatogenesis" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "HPA020322: AB_10960562" "unprognostic (2.44e-1)" "unprognostic (3.76e-1)" "unprognostic (1.50e-1)" "unprognostic (5.94e-2)" "unprognostic (4.96e-2)" "unprognostic (7.10e-3)" "unprognostic (1.64e-2)" "unprognostic (1.41e-2)" "unprognostic (3.26e-1)" "unprognostic (5.02e-2)" "unprognostic (5.83e-4)" "unprognostic (1.43e-1)" "unprognostic (8.88e-13)" "unprognostic (5.16e-2)" "unprognostic (1.32e-1)" "unprognostic (8.81e-2)" "unprognostic (3.08e-2)" 0.3 0.2 0.3 0.1 0.2 0.2 0.1 0.2 1.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.5 0.2 0.0 0.0 1.9 0.3 0.4 0.0 0.5 0.0 1.2 0.6 0.4 0.1 0.0 0.0 0.0 0.0 0.2 1.0 0.7 0.0 0.2 1.8 0.0 33.6 0.5 2.2 0.3 0.0 0.9 0.6 0.0 0.4 0.5 0.0 0.0 0.4 0.0 0.0 0.0 0.3 2.1 0.1 0.2 1.6 0.0 0.0 0.0 0.0 0.7 0.0 0.2 0.4 0.0 0.0 1.2 0.5 0.5 0.8 0.3 0.0 0.0 0.0 0.7 0.0 0.9 0.9 0.0 0.6 0.0 1.0 0.0 0.0 0.3 0.0 0.4 0.0 0.0 0.0 7.3 0.2 1.0 3.4 0.9 0.1 0.0 2.0 0.0 0.1 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 6.0 0.0 0.3 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.6 0.0 16.8 8.6 0.0 0.0 4.2 42.5 0.0 0.0 0.0 0.0 56.4 5.8 0.3 0.2 0.2 1.0 0.4 0.5 0.3 0.4 0.4 0.2 0.5 0.4 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.8 0.6 0.3 0.0 0.0 1.8 0.0 3.1 0.0 0.0 0.0 0.1 76.1 0.2 0.0 0.1 0.0 0.0 0.1 0.2 0.2 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 144.1 0.9 0.1 0.0 0.0 0.9 0.0 2.1 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.1 0.0 0.0 0.0 2.1 0.0 3.8 2.6 0.0 0.0 4.7 4.0 0.0 0.0 0.1 CPA6 CPAH ENSG00000165078 "Carboxypeptidase A6" Q8N4T0 8 67422038-67746378 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 2.3;prostate: 2.7;retina: 2.2" "Cell type enhanced" "Detected in some" "Basal prostatic cells: 31.7;Early spermatids: 21.7;Microglial cells: 12.2;Muller glia cells: 22.5;Pancreatic endocrine cells: 21.5;Paneth cells: 12.8;Prostatic glandular cells: 11.3;Urothelial cells: 36.6" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CACO-2: 2.5;EFO-21: 1.5;Hep G2: 3.4;OE19: 1.5" "Region enriched" "Detected in some" 9 "olfactory bulb: 12.6" "Low region specificity" "Detected in all" "Secreted to extracellular matrix" NA NA "Cluster 37: Intestine - Unknown function" "Cluster 39: CACO-2 - Unknown function" "Cluster 22: Epithelial cell types - Mixed function" "unprognostic (2.85e-2)" "unprognostic (1.95e-1)" "unprognostic (1.72e-2)" "unprognostic (1.14e-1)" "unprognostic (2.58e-1)" "unprognostic (2.24e-1)" "unprognostic (2.08e-1)" "unprognostic (2.88e-1)" "unprognostic (9.35e-2)" "unprognostic (1.65e-1)" "unprognostic (5.23e-2)" "unprognostic (6.99e-2)" "unprognostic (3.57e-4)" "unprognostic (9.61e-5)" "unprognostic (1.75e-1)" "unprognostic (9.09e-2)" "unprognostic (1.41e-2)" 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.6 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 2.3 2.2 0.0 0.2 0.0 0.0 0.2 0.8 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.0 1.2 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 1.5 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.0 31.7 0.0 5.7 0.2 0.1 0.4 0.2 0.0 0.1 0.0 0.0 0.0 0.0 2.3 0.0 0.0 21.7 0.1 0.0 0.1 2.4 0.0 1.6 0.4 0.0 0.4 0.0 0.7 0.0 0.0 0.0 0.0 0.1 1.7 1.3 2.2 0.0 0.0 0.0 3.2 1.8 0.2 0.0 12.2 0.1 22.5 0.0 3.0 1.3 21.5 12.8 0.0 0.0 11.3 0.0 0.0 0.0 1.0 0.0 0.1 0.3 0.0 0.0 0.8 0.0 0.0 0.6 0.0 5.7 36.6 CYP21A2 "CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B" ENSG00000231852 "Cytochrome P450 family 21 subfamily A member 2" P08686 6 32038327-32041644 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Steroidogenesis "Monooxygenase, Oxidoreductase" "Congenital adrenal hyperplasia, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 46 "adrenal gland: 2041.7" "Cell type enriched" "Detected in some" 6 "Hepatocytes: 15.9" "Cancer enhanced" "Detected in some" "liver cancer: 2.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "HDLM-2: 3.3" "Not detected" "Not detected" "Not detected" "Not detected" "HPA048979, HPA053371" Enhanced NA NA "Cluster 17: Adrenal gland - Steroid metabolism" "Cluster 44: HDLM-2 - Immune response" "Cluster 15: Hepatocytes - Hemostasis" "HPA048979: AB_2680584, HPA053371: AB_2682131" "unprognostic (1.03e-2)" "unprognostic (1.65e-1)" "unprognostic (1.02e-4)" "unprognostic (2.58e-1)" "unprognostic (2.97e-1)" "unprognostic (2.93e-2)" "unprognostic (2.76e-2)" "unprognostic (8.75e-2)" "unprognostic (1.39e-1)" "unprognostic (1.71e-1)" "unprognostic (1.41e-1)" "unprognostic (1.93e-1)" "unprognostic (6.67e-7)" "unprognostic (7.39e-2)" "unprognostic (5.24e-2)" "unprognostic (1.09e-1)" "unprognostic (1.82e-1)" 2.0 2041.7 0.0 0.0 0.0 0.0 1.5 0.0 0.6 1.9 0.0 2.5 0.0 1.5 0.6 0.6 2.4 0.0 2.9 0.0 0.0 7.0 44.8 0.8 0.0 0.0 0.0 4.3 0.9 0.0 1.9 0.0 0.0 1.9 0.0 0.0 4.0 0.0 0.3 0.7 1.1 0.0 0.0 5.5 0.8 0.8 0.0 0.0 2.3 0.0 0.0 2.1 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 0.1 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.1 0.2 0.0 0.4 2.4 0.5 0.3 1.5 0.8 0.0 0.0 0.0 0.4 0.0 0.0 0.2 0.1 0.1 0.8 0.9 1.8 0.0 0.1 0.0 0.0 1.6 0.0 0.2 1.3 0.4 0.0 15.9 0.0 0.0 0.1 0.0 0.0 0.3 0.3 0.1 0.6 0.1 1.8 0.0 0.0 0.3 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.2 0.0 2.0 1.2 0.6 0.0 0.3 0.6 0.6 0.4 0.0 0.0 0.0 0.3 1.0 0.0 0.0 CYP27A1 "CP27, CTX, CYP27" ENSG00000135929 "Cytochrome P450 family 27 subfamily A member 1" Q02318 2 218781749-218815293 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol metabolism" "Monooxygenase, Oxidoreductase" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 7 "liver: 594.4" "Cell type enhanced" "Detected in many" "Hepatocytes: 404.3;Hofbauer cells: 148.9;Proximal enterocytes: 206.3" "Group enriched" "Detected in all" 4 "liver cancer: 176.9;melanoma: 85.7" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 8 "classical monocyte: 151.5;neutrophil: 126.3" "Group enriched" "Detected in many" 21 "granulocytes: 126.3;monocytes: 151.5" "Cell line enhanced" "Detected in many" "Hep G2: 299.6;HSkMC: 54.7;RPTEC TERT1: 78.5;SK-MEL-30: 103.6;WM-115: 42.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA059155 Enhanced Approved Mitochondria,Cytosol NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" Mitochondria Cytosol "HPA059155: AB_2683933" "prognostic favorable (1.05e-4)" "unprognostic (4.21e-2)" "unprognostic (2.34e-1)" "unprognostic (1.83e-3)" "unprognostic (3.71e-3)" "unprognostic (1.31e-2)" "prognostic favorable (8.62e-6)" "unprognostic (6.04e-2)" "unprognostic (1.73e-1)" "unprognostic (4.04e-1)" "unprognostic (1.25e-3)" "unprognostic (8.76e-3)" "unprognostic (1.09e-3)" "unprognostic (1.08e-1)" "unprognostic (7.51e-2)" "unprognostic (1.64e-1)" "unprognostic (1.36e-1)" 23.1 50.3 45.2 15.7 59.0 1.3 21.8 57.0 59.3 27.6 75.6 27.6 77.8 19.8 11.6 11.9 34.0 19.1 30.7 42.2 49.3 46.4 594.4 71.7 24.6 63.0 56.1 32.6 8.3 18.5 29.6 6.2 62.7 41.8 20.7 22.5 40.4 29.5 37.9 17.5 81.9 13.2 50.6 13.0 13.8 12.6 58.8 23.6 12.6 49.2 28.0 24.3 23.2 69.2 0.2 0.0 2.7 0.2 4.6 3.3 0.4 1.9 11.7 3.9 7.8 13.7 0.8 0.0 4.3 7.6 0.2 0.1 0.0 0.0 1.7 1.4 1.0 0.0 0.4 299.6 16.2 0.4 0.3 54.7 0.5 0.1 0.0 12.8 5.9 0.0 0.3 0.1 8.3 0.0 0.0 0.2 2.3 0.3 0.5 0.1 2.4 0.5 78.5 0.2 0.2 0.2 0.1 0.0 103.6 2.4 1.6 2.2 5.9 0.0 0.2 0.1 6.0 0.0 0.0 0.1 0.1 0.3 42.9 0.0 151.5 0.4 0.2 17.1 0.3 0.7 0.2 0.5 6.5 0.0 0.1 0.0 126.3 0.0 1.2 0.8 0.0 44.1 45.2 59.0 57.0 59.3 42.2 49.3 63.0 56.1 62.7 50.6 58.8 69.2 10.6 3.2 28.9 33.6 0.9 5.2 52.4 8.5 21.6 15.3 12.7 18.8 5.1 17.2 11.3 3.7 27.1 0.7 0.5 37.0 9.8 12.1 1.0 12.6 4.3 10.3 24.5 8.4 2.2 12.0 0.7 35.4 2.6 14.8 2.5 1.9 19.6 404.3 148.9 10.1 3.9 20.0 4.1 18.2 5.1 1.0 47.5 104.3 49.8 15.0 92.4 28.7 0.0 26.7 108.5 9.7 44.0 26.7 0.0 43.3 206.3 76.9 21.4 14.1 0.0 12.8 7.2 0.7 0.1 3.2 3.1 1.2 2.3 1.2 30.3 20.4 CYP2E1 CYP2E ENSG00000130649 "Cytochrome P450 family 2 subfamily E member 1" P05181 10 133520406-133561220 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" "Monooxygenase, Oxidoreductase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 309 "liver: 10379.8" "Cell type enriched" "Detected in many" 58 "Hepatocytes: 6272.7" "Cancer enriched" "Detected in some" 278 "liver cancer: 265.3" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "MAIT T-cell: 2.5;myeloid DC: 6.2" "Group enriched" "Detected in many" 16 "dendritic cells: 6.2;T-cells: 2.5" "Cell line enhanced" "Detected in many" "HaCaT: 11.0;HL-60: 8.9;HMC-1: 8.9;NB-4: 24.0" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA009128, HPA029564" Enhanced Approved "Endoplasmic reticulum,Mitochondria" "Intracellular and membrane" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 62: Liver - Hemostasis" "Cluster 24: NB-4 - Immune response" "Cluster 2: Hepatocytes - Metabolism" "Endoplasmic reticulum, Mitochondria" "HPA009128: AB_1078613, HPA029564: AB_10602213" "unprognostic (6.32e-2)" "unprognostic (1.51e-2)" "unprognostic (3.83e-5)" "unprognostic (1.27e-1)" "unprognostic (3.37e-2)" "unprognostic (1.26e-1)" "unprognostic (2.92e-3)" "unprognostic (6.36e-3)" "unprognostic (2.41e-2)" "unprognostic (1.49e-1)" "unprognostic (1.63e-1)" "unprognostic (3.21e-2)" "unprognostic (1.70e-4)" "unprognostic (1.72e-1)" "unprognostic (8.36e-2)" "unprognostic (3.78e-1)" "unprognostic (9.59e-2)" 2.8 2.9 5.4 0.6 5.4 0.8 3.0 9.1 7.5 4.9 3.0 5.0 1.4 4.5 8.3 16.7 5.5 2.5 2.1 5.5 5.5 9.1 10379.8 2.6 2.0 6.1 5.5 4.1 12.4 0.6 4.1 1.4 6.7 5.3 1.2 11.5 3.6 6.1 2.8 13.8 2.2 2.2 5.0 7.2 6.7 3.7 6.3 1.7 4.0 0.9 33.6 3.5 3.2 7.5 0.1 0.0 0.3 1.0 3.5 1.9 0.7 1.6 4.5 0.0 0.3 0.0 2.7 1.4 0.2 0.5 0.0 11.0 0.0 0.2 0.4 0.3 1.5 1.8 0.2 1.3 0.6 8.9 8.9 1.0 0.2 0.0 0.7 1.9 0.0 3.1 0.6 0.4 1.0 0.7 0.6 24.0 6.4 4.3 0.4 0.4 6.1 0.0 2.0 0.0 0.0 0.0 4.2 0.0 0.6 0.2 0.3 0.9 0.0 1.4 0.4 2.3 1.0 2.2 1.0 3.0 1.5 7.4 0.1 0.0 0.0 0.0 0.0 0.0 2.5 0.0 1.1 0.6 6.2 0.0 0.1 0.0 0.0 0.1 0.2 0.0 0.0 0.2 5.4 5.4 9.1 7.5 5.5 5.5 6.1 5.5 6.7 5.0 6.3 7.5 0.8 0.0 1.1 5.5 9.2 2.3 0.2 0.7 0.6 5.7 0.6 0.5 2.8 48.6 1.9 0.0 2.1 0.0 0.4 0.1 0.0 1.6 2.1 0.6 0.8 4.6 0.0 67.6 6.7 1.3 0.1 1.1 1.5 0.5 1.3 0.7 67.1 6272.7 0.0 8.4 5.3 0.0 0.0 108.0 2.8 2.1 1.5 0.3 0.0 1.9 0.4 0.7 0.0 2.0 2.2 3.2 0.0 2.6 0.3 0.6 0.0 0.6 2.2 5.8 0.0 0.2 0.6 4.1 4.2 2.0 7.5 0.1 5.7 0.2 0.0 0.0 CYP3A4 CYP3A3 ENSG00000160868 "Cytochrome P450 family 3 subfamily A member 4" P08684 7 99756960-99784248 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol metabolism" "Monooxygenase, Oxidoreductase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 4 "liver: 3796.2" "Group enriched" "Detected in some" 40 "Hepatocytes: 2612.9;Proximal enterocytes: 1685.2" "Cancer enriched" "Detected in some" 240 "liver cancer: 351.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 2.0;NB-4: 2.2;RPMI-8226: 3.4;SCLC-21H: 1.3;SH-SY5Y: 2.0" "Low region specificity" "Detected in all" "CAB033671, HPA072245, HPA075539" Enhanced Approved Vesicles,Cytosol NA NA "Cluster 85: Liver - Metabolism" "Cluster 24: NB-4 - Immune response" "Cluster 2: Hepatocytes - Metabolism" Cytosol Vesicles "CAB033671: AB_782375, HPA072245: , HPA075539: " "unprognostic (4.55e-2)" "unprognostic (8.95e-2)" "unprognostic (8.08e-2)" "unprognostic (1.63e-1)" "unprognostic (5.89e-2)" "unprognostic (5.37e-2)" "unprognostic (7.07e-3)" "unprognostic (9.09e-2)" "unprognostic (8.27e-3)" "unprognostic (4.92e-2)" "unprognostic (3.78e-2)" "unprognostic (6.42e-2)" "unprognostic (1.89e-8)" "unprognostic (2.59e-1)" "unprognostic (1.75e-2)" "unprognostic (9.79e-2)" "unprognostic (6.82e-2)" 0.3 3.8 0.1 1.1 0.3 0.0 0.3 0.0 0.8 0.1 0.0 4.6 797.6 0.6 0.2 0.4 0.1 0.6 0.1 0.1 0.0 4.9 3796.2 0.1 0.9 0.0 0.0 0.1 43.4 0.0 1.0 0.0 0.0 0.2 2.2 0.4 0.3 0.0 2.4 1.9 853.0 0.0 0.0 0.1 1.1 1.0 0.1 0.4 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.1 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.1 0.0 0.8 0.1 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 2.2 0.2 0.0 0.0 0.0 0.8 3.4 0.0 0.1 1.3 2.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.7 0.0 0.3 0.0 0.4 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.8 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 2.2 0.4 0.8 0.2 0.0 0.0 0.0 0.0 0.4 32.9 0.0 0.0 0.0 0.3 0.0 5.6 0.0 0.1 0.4 0.0 0.0 1.4 0.0 26.7 0.6 0.9 0.0 0.0 0.0 0.1 0.0 0.0 30.0 2612.9 0.0 0.0 0.6 29.6 2.0 52.8 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.5 0.2 0.1 38.9 0.0 0.0 0.6 1685.2 3.0 0.0 0.0 0.0 0.1 0.0 0.1 0.9 0.0 0.9 0.1 2.3 0.5 16.1 1.1 DLD "DLDH, E3, GCSL, LAD, OGDC-E3" ENSG00000091140 "Dihydrolipoamide dehydrogenase" P09622 7 107891162-107931730 "Citric acid cycle related proteins, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "tongue: 357.0" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 356.2;Distal tubular cells: 226.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044849 Supported Approved Nucleoplasm,Mitochondria NA NA 10000000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria Nucleoplasm "HPA044849: AB_2679111" "unprognostic (2.01e-3)" "unprognostic (2.26e-1)" "unprognostic (1.27e-2)" "unprognostic (9.27e-2)" "unprognostic (5.01e-3)" "unprognostic (9.27e-2)" "unprognostic (2.48e-1)" "unprognostic (2.83e-2)" "unprognostic (1.19e-1)" "unprognostic (3.95e-2)" "unprognostic (9.43e-2)" "unprognostic (7.35e-2)" "prognostic favorable (7.58e-9)" "unprognostic (4.08e-2)" "unprognostic (1.88e-1)" "unprognostic (4.45e-3)" "unprognostic (1.18e-1)" 108.7 98.9 22.7 42.1 23.7 54.0 49.0 27.1 29.1 36.3 35.6 109.0 81.8 45.3 21.2 94.1 34.3 48.5 264.1 23.1 29.5 153.3 112.8 39.3 50.1 27.1 27.4 30.0 49.2 136.7 27.8 43.1 26.6 45.7 99.3 35.0 50.2 50.3 295.0 38.9 71.9 67.7 24.9 38.4 80.5 31.3 25.7 43.2 64.2 357.0 67.5 66.1 32.7 23.4 171.4 134.5 74.8 127.9 104.6 91.4 88.4 96.5 80.8 110.6 86.2 159.5 95.5 165.9 159.6 103.0 177.7 110.9 150.2 135.8 166.1 111.1 88.4 116.9 175.6 116.7 80.3 194.7 116.0 104.8 97.6 116.4 63.4 72.3 134.0 137.0 298.5 119.7 121.8 188.1 161.8 138.9 87.4 206.0 98.2 113.1 117.8 225.9 151.8 250.8 92.3 99.9 156.3 262.1 143.9 149.9 100.5 165.8 87.9 120.7 97.3 238.1 149.4 89.3 187.1 114.6 115.0 204.1 130.2 132.7 63.9 136.0 46.9 81.6 49.4 37.8 46.8 46.8 87.2 38.5 47.9 50.5 39.9 68.1 116.9 29.9 49.0 64.2 22.7 23.7 27.1 29.1 23.1 29.5 27.1 27.4 26.6 24.9 25.7 23.4 26.7 28.9 20.7 14.7 26.3 31.4 42.7 124.7 31.3 47.1 24.0 19.2 356.2 51.5 70.5 79.1 22.9 110.2 27.3 56.1 226.9 69.3 10.2 27.6 26.2 32.2 30.6 53.9 23.9 55.9 62.7 36.3 36.7 28.0 26.6 35.3 26.0 86.8 69.2 21.9 25.3 44.1 114.0 41.0 26.5 7.3 23.3 37.5 37.4 15.9 62.2 36.0 38.1 21.1 16.7 42.6 51.4 42.2 30.7 24.3 60.0 178.9 55.5 45.5 26.3 28.4 44.8 55.2 51.5 48.0 32.4 108.4 29.5 73.7 78.7 39.2 EPX "EPO, EPP, EPX-PEN" ENSG00000121053 "Eosinophil peroxidase" P11678 17 58192726-58205174 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Hydrogen peroxide" "Oxidoreductase, Peroxidase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 17 "bone marrow: 33.7" "Cell type enhanced" "Detected in some" "Excitatory neurons: 1.5;Inhibitory neurons: 1.2;Microglial cells: 1.0;Oligodendrocyte precursor cells: 2.0;Oligodendrocytes: 1.0" "Not detected" "Not detected" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 23 "eosinophil: 2.2" "Lineage enriched" "Detected in single" 23 "granulocytes: 2.2" "Cell line enriched" "Detected in some" 68 "NB-4: 248.2" "Low region specificity" "Detected in some" "Not detected" "Not detected" HPA076792 Enhanced NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 24: NB-4 - Immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA076792: " "unprognostic (5.67e-2)" "unprognostic (1.73e-2)" "unprognostic (3.36e-2)" "unprognostic (3.30e-1)" "unprognostic (2.18e-1)" "unprognostic (1.34e-3)" "unprognostic (4.83e-1)" "unprognostic (3.16e-2)" "unprognostic (1.41e-1)" "unprognostic (1.52e-2)" "unprognostic (1.71e-4)" "unprognostic (7.38e-2)" "unprognostic (1.64e-1)" "unprognostic (2.02e-1)" "unprognostic (5.43e-2)" "unprognostic (1.02e-2)" "unprognostic (1.73e-1)" 0.0 0.1 0.0 0.2 0.2 33.7 0.0 0.3 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.1 0.2 0.4 0.4 0.0 0.0 0.2 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.5 0.3 0.0 0.1 0.5 0.1 0.0 0.0 1.3 0.1 0.1 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.1 0.0 0.0 0.0 3.6 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.1 0.2 248.2 0.0 0.0 0.0 0.3 0.1 0.1 0.0 0.0 0.5 0.1 0.0 0.0 0.1 0.1 0.2 2.9 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 FDXR "ADR, ADXR" ENSG00000161513 "Ferredoxin reductase" P22570 17 74862497-74873031 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cholesterol metabolism, Electron transport, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transport" Oxidoreductase "Deafness, Disease variant, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "adrenal gland: 343.1" "Group enriched" "Detected in many" 7 "Granulosa cells: 329.3;Theca cells: 794.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "BEWO: 89.5;Hep G2: 173.5" "Low region specificity" "Detected in all" "CAB008597, CAB009818, HPA044393, HPA053673" Enhanced Enhanced Mitochondria NA NA "Cluster 15: NK-cells - Transcription" "Cluster 17: Adrenal gland - Steroid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 52: Non-specific - Transcription" Mitochondria "CAB008597: AB_1615557, CAB009818: AB_2102601, HPA044393: AB_2678927, HPA053673: AB_2682225" "unprognostic (2.69e-2)" "unprognostic (1.17e-3)" "unprognostic (7.51e-2)" "prognostic favorable (2.38e-4)" "unprognostic (3.43e-2)" "unprognostic (1.20e-1)" "unprognostic (1.53e-1)" "unprognostic (1.68e-2)" "unprognostic (2.29e-1)" "unprognostic (1.50e-1)" "unprognostic (1.09e-1)" "unprognostic (6.30e-2)" "unprognostic (1.42e-2)" "unprognostic (1.19e-2)" "unprognostic (4.50e-2)" "unprognostic (4.03e-2)" "unprognostic (2.13e-1)" 3.9 343.1 6.9 2.4 8.4 2.2 3.8 7.8 8.1 7.8 8.6 9.7 4.6 6.7 5.1 26.0 12.9 4.1 6.0 6.6 6.7 6.5 14.9 5.3 2.9 7.6 7.9 20.5 12.9 5.9 4.1 3.0 7.5 6.7 3.2 0.5 7.1 4.4 7.7 16.4 5.6 2.3 7.4 33.9 7.6 45.6 7.0 4.7 6.0 1.7 2.5 6.2 10.5 7.5 12.5 65.6 9.6 10.8 6.8 9.1 89.5 14.8 15.9 8.6 17.1 18.3 10.8 29.6 2.6 6.2 4.8 24.9 6.9 18.4 2.5 27.9 15.2 22.6 10.6 173.5 19.0 5.0 75.1 29.2 20.3 9.1 3.1 7.0 43.9 10.9 36.1 4.8 13.4 53.4 19.7 10.6 5.5 11.8 14.5 10.6 16.4 16.2 7.1 21.0 5.2 12.1 10.0 21.7 11.2 10.9 47.4 4.7 20.5 5.9 51.9 9.4 7.4 12.7 2.3 6.5 16.1 7.7 20.6 1.7 6.0 5.0 5.6 4.5 5.0 4.8 5.1 6.8 7.3 2.4 4.4 5.4 2.0 10.3 3.4 1.4 15.4 5.2 6.9 8.4 7.8 8.1 6.6 6.7 7.6 7.9 7.5 7.4 7.0 7.5 4.0 3.2 3.9 7.5 8.2 9.7 17.8 42.6 17.1 4.9 6.6 8.4 3.8 5.7 23.3 9.2 4.2 53.2 2.8 18.6 5.9 11.1 6.5 28.2 4.3 4.6 7.1 4.0 1.4 7.9 18.9 12.9 13.7 3.5 5.7 329.3 12.5 13.9 23.1 3.3 2.2 13.1 36.7 6.2 2.7 14.9 5.9 4.6 5.4 1.0 3.9 11.4 8.2 3.0 1.3 9.0 16.9 4.5 7.1 5.2 24.9 21.7 73.6 5.1 0.0 6.2 18.3 6.3 6.1 33.7 18.2 46.1 8.6 794.1 20.3 17.4 GLB1 "EBP, ELNR1" ENSG00000170266 "Galactosidase beta 1" P16278 3 32996609-33097202 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Glycosidase, Hydrolase" "Disease variant, Gangliosidosis, Mucopolysaccharidosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "BEWO: 857.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008382, HPA040610, HPA069503" Enhanced Supported "Golgi apparatus,Vesicles" "Intracellular and membrane" NA NA 2700000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 28: BEWO - Transcription regulation" "Cluster 4: Macrophages - Innate immune response" Vesicles "Golgi apparatus" "CAB008382: AB_590642, HPA040610: AB_2677039, HPA069503: AB_2686142" "unprognostic (1.51e-2)" "unprognostic (3.66e-2)" "unprognostic (5.02e-3)" "unprognostic (9.66e-3)" "unprognostic (9.61e-3)" "unprognostic (1.04e-1)" "unprognostic (2.31e-3)" "unprognostic (1.32e-1)" "unprognostic (2.08e-1)" "unprognostic (1.16e-1)" "unprognostic (2.06e-1)" "unprognostic (2.08e-1)" "prognostic favorable (1.14e-5)" "unprognostic (3.05e-1)" "unprognostic (2.33e-1)" "unprognostic (2.20e-1)" "unprognostic (5.85e-2)" 22.0 36.1 12.1 27.8 13.0 21.9 20.5 12.5 14.8 33.4 16.0 43.5 43.0 21.9 103.6 15.4 28.2 32.0 15.5 12.5 14.8 46.0 48.2 42.7 25.8 14.3 12.9 21.4 30.8 59.4 18.5 53.8 15.4 23.2 45.6 14.9 25.3 29.3 7.7 15.8 31.0 30.6 12.4 24.4 35.5 13.5 13.5 17.5 52.8 10.8 23.0 31.8 16.2 15.1 37.4 63.6 39.8 48.3 241.9 123.7 857.2 59.1 157.6 73.7 95.1 91.3 86.5 17.9 50.9 120.9 53.9 35.1 38.1 75.5 53.7 104.9 33.0 69.9 35.3 47.4 124.3 50.5 69.9 144.9 70.2 67.0 39.2 144.1 116.5 24.7 64.3 67.0 81.8 44.6 29.6 31.6 26.4 78.0 27.0 24.7 26.4 86.6 78.4 54.4 12.0 40.3 75.0 120.2 74.4 69.3 80.3 130.2 67.7 46.8 32.2 65.2 50.1 53.2 87.9 5.9 99.6 71.2 36.7 43.9 146.2 86.4 29.2 125.8 40.4 37.9 34.3 31.8 166.5 35.6 17.9 21.8 56.6 26.0 92.1 35.1 77.1 91.9 12.1 13.0 12.5 14.8 12.5 14.8 14.3 12.9 15.4 12.4 13.5 15.1 8.7 19.2 25.3 39.2 18.6 6.0 13.6 60.1 10.8 11.3 11.5 7.5 9.1 34.3 43.3 27.6 6.2 100.1 14.1 41.9 27.4 53.5 24.8 18.7 16.0 17.4 16.9 20.6 46.7 35.4 55.3 29.2 26.0 27.1 26.6 20.6 19.6 39.7 79.5 5.0 46.0 23.5 40.7 43.9 13.9 5.0 15.2 41.7 14.2 23.4 64.6 16.5 10.3 27.2 24.2 28.1 43.4 21.1 19.8 9.9 36.2 33.1 31.0 16.2 13.1 12.9 16.3 1.0 6.6 10.1 3.4 49.1 18.7 51.0 32.0 12.1 GPAT3 "AGPAT10, AGPAT9, HMFN0839, LPAAT-theta, MAG1, MGC11324" ENSG00000138678 "Glycerol-3-phosphate acyltransferase 3" Q53EU6 4 83535914-83605875 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "kidney: 88.4" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 60.0;Early spermatids: 82.3;Macrophages: 60.5;Proximal enterocytes: 56.2;Proximal tubular cells: 67.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "basophil: 182.5" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "CAPAN-2: 157.6;GAMG: 116.4;HMC-1: 57.4;U-87 MG: 66.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA029414 Approved NA NA "Cluster 38: Basophils - Unknown function" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 41: Macrophages - Immune response" "HPA029414: AB_10601562" "unprognostic (9.51e-2)" "unprognostic (1.43e-2)" "unprognostic (5.67e-2)" "unprognostic (1.70e-1)" "unprognostic (3.50e-3)" "unprognostic (2.61e-2)" "unprognostic (2.05e-1)" "unprognostic (1.25e-1)" "unprognostic (1.09e-2)" "unprognostic (4.30e-2)" "unprognostic (1.12e-1)" "unprognostic (2.92e-1)" "prognostic favorable (2.71e-9)" "unprognostic (3.74e-1)" "unprognostic (3.45e-2)" "unprognostic (2.53e-3)" "prognostic unfavorable (8.21e-4)" 14.0 1.0 0.9 5.7 1.1 11.9 6.5 3.9 2.7 5.5 8.9 13.7 39.9 3.7 1.2 8.3 3.6 8.6 25.3 1.0 2.8 88.4 18.1 4.2 2.0 5.5 3.4 16.1 1.2 23.2 5.0 1.5 5.5 1.6 11.1 1.2 3.5 3.6 37.6 2.6 35.6 3.5 2.0 4.7 15.2 7.4 2.7 1.7 19.8 12.5 2.1 6.0 6.3 1.8 30.6 29.6 0.0 0.4 1.5 3.7 0.6 2.4 4.3 0.6 0.6 2.2 157.6 0.0 3.2 5.9 116.4 6.8 14.3 2.8 0.5 2.1 6.7 0.0 9.2 29.7 4.2 8.9 57.4 2.0 0.2 1.1 3.5 11.5 15.0 8.5 25.1 23.7 0.6 3.1 2.3 2.2 0.7 45.6 12.5 0.3 6.7 11.6 29.8 2.0 0.7 0.0 5.8 6.1 17.3 1.6 1.2 1.6 0.7 6.9 12.3 6.9 28.9 1.1 2.2 0.0 66.4 17.6 52.2 182.5 33.2 4.0 0.6 27.8 6.0 0.1 3.5 2.0 81.4 0.1 2.5 1.2 91.1 1.6 23.6 0.3 2.3 10.4 0.9 1.1 3.9 2.7 1.0 2.8 5.5 3.4 5.5 2.0 2.7 1.8 4.8 6.4 6.8 0.0 1.3 0.0 60.0 0.0 8.0 0.8 10.2 4.1 0.0 4.3 5.0 11.0 0.0 0.4 0.8 18.6 15.6 4.8 82.3 1.0 1.1 5.4 1.2 6.1 0.0 6.8 1.3 5.5 34.7 2.4 7.6 0.8 7.5 13.2 14.8 5.0 0.0 9.9 0.0 11.3 0.0 21.7 1.2 60.5 0.0 0.0 28.7 0.1 1.0 0.0 0.0 10.4 6.7 0.7 1.2 32.4 56.2 67.4 1.5 0.3 6.6 5.8 1.7 10.6 1.9 5.2 0.0 1.0 7.3 4.9 3.6 28.9 GPAT4 "AGPAT6, DKFZp586M1819, LPAAT-zeta, TSARG7" ENSG00000158669 "Glycerol-3-phosphate acyltransferase 4" Q86UL3 8 41577187-41625001 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016471 Approved NA NA "Cluster 44: Non-specific - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 30: Mammary glandular cells - Lactation" "HPA016471: AB_1844649" "unprognostic (3.05e-2)" "unprognostic (4.05e-2)" "unprognostic (4.24e-2)" "prognostic unfavorable (9.37e-4)" "unprognostic (7.45e-2)" "unprognostic (2.99e-3)" "unprognostic (5.08e-2)" "unprognostic (5.11e-2)" "unprognostic (3.79e-2)" "prognostic unfavorable (2.20e-4)" "unprognostic (1.98e-2)" "prognostic favorable (4.15e-4)" "unprognostic (1.73e-3)" "unprognostic (3.16e-2)" "unprognostic (3.35e-1)" "unprognostic (2.04e-2)" "prognostic favorable (5.65e-4)" 23.6 33.6 13.5 28.0 15.3 28.4 42.4 29.7 17.6 24.7 25.0 21.3 19.7 28.6 12.8 16.3 21.0 23.1 20.4 13.4 15.0 30.1 32.7 23.9 22.3 16.2 16.5 23.0 23.1 40.5 16.2 27.2 15.6 18.3 21.7 15.4 25.4 20.3 57.6 18.4 19.0 33.2 15.4 21.2 26.8 24.2 15.7 22.1 20.0 39.9 27.4 24.6 18.8 16.8 39.0 42.4 49.7 38.9 53.1 64.1 43.7 82.7 70.8 61.4 63.6 28.7 76.1 53.8 56.6 68.7 75.4 22.0 58.7 37.3 78.8 58.0 32.4 63.0 49.0 26.5 31.0 6.8 87.1 40.6 26.9 64.0 23.0 52.5 64.1 52.7 47.9 61.5 63.4 16.5 60.0 17.3 53.1 71.3 22.5 34.7 49.8 29.2 36.4 57.5 32.4 44.7 32.2 43.9 89.1 56.5 60.9 42.4 47.0 63.0 43.8 73.0 62.6 33.0 47.9 58.7 51.9 36.9 63.1 16.0 17.0 7.8 12.5 15.9 11.6 8.6 9.6 12.6 21.0 9.9 8.5 8.5 3.8 5.8 14.3 8.0 9.7 13.8 13.5 15.3 29.7 17.6 13.4 15.0 16.2 16.5 15.6 15.4 15.7 16.8 20.0 3.2 31.2 0.0 14.5 0.0 13.2 0.0 11.4 16.9 50.2 19.6 0.0 27.1 13.6 11.0 10.4 33.9 18.4 10.8 3.9 41.3 40.6 14.1 19.4 21.7 17.0 21.5 0.0 39.8 42.5 13.1 27.0 29.2 2.5 21.2 18.2 62.4 27.1 15.2 0.0 14.2 0.0 28.1 0.0 58.7 12.8 31.7 0.0 0.0 31.2 11.8 9.2 0.0 0.0 44.9 11.3 10.5 23.9 27.7 13.3 28.2 5.8 15.1 6.6 20.3 11.6 4.3 14.8 10.1 0.0 40.4 16.7 23.0 11.1 18.2 GUSB ENSG00000169919 "Glucuronidase beta" P08236 7 65960684-65982215 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Glycosidase, Hydrolase" "Cancer-related genes, Disease variant, Mucopolysaccharidosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Karpas-707: 213.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036322, HPA036323" Approved Supported Vesicles "Intracellular and membrane" NA NA 330000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 2: Karpas-707 - Immune response" "Cluster 4: Macrophages - Innate immune response" Vesicles "HPA036322: AB_10670796, HPA036323: AB_2675059" "unprognostic (1.54e-2)" "unprognostic (6.49e-2)" "unprognostic (1.18e-2)" "unprognostic (3.50e-1)" "unprognostic (2.58e-2)" "unprognostic (4.46e-2)" "unprognostic (2.89e-1)" "unprognostic (1.56e-3)" "unprognostic (1.32e-1)" "unprognostic (2.32e-1)" "unprognostic (7.00e-3)" "unprognostic (1.91e-1)" "unprognostic (3.34e-2)" "unprognostic (8.83e-3)" "unprognostic (1.98e-1)" "unprognostic (5.06e-1)" "unprognostic (1.45e-1)" 28.4 18.2 11.0 22.3 12.3 84.2 80.9 12.0 16.1 26.7 14.3 38.2 36.1 26.2 41.8 16.4 24.6 27.6 19.6 10.7 11.5 25.1 104.0 35.7 25.6 13.2 12.2 19.9 33.6 30.3 12.6 48.2 13.2 20.2 41.9 9.7 32.9 21.2 10.9 18.8 29.8 19.1 11.9 34.0 38.1 19.5 13.0 22.7 27.7 14.4 24.0 27.3 15.4 13.5 67.0 26.5 25.2 56.3 80.9 49.1 35.3 21.3 56.8 45.0 42.1 37.0 67.8 30.9 32.3 26.8 24.1 27.5 16.5 25.1 26.8 27.3 34.1 41.5 40.9 27.3 39.7 89.6 67.1 33.4 26.7 26.3 33.3 54.5 39.3 18.0 63.2 213.5 30.5 50.3 34.2 92.0 17.9 103.0 21.0 34.4 55.9 172.4 29.4 42.8 36.2 32.7 55.6 129.1 72.3 29.9 71.1 88.8 28.5 55.3 49.3 21.8 53.6 119.6 151.9 50.0 41.0 116.3 68.3 26.0 80.1 65.7 32.0 103.0 28.4 27.7 24.7 28.4 80.5 22.6 16.8 19.5 13.2 46.6 93.5 34.2 34.5 51.4 11.0 12.3 12.0 16.1 10.7 11.5 13.2 12.2 13.2 11.9 13.0 13.5 53.1 51.3 58.7 10.1 33.0 18.0 32.0 51.9 29.0 12.2 26.1 19.9 12.2 48.6 48.9 29.5 8.4 81.9 32.6 52.2 5.9 41.1 59.1 28.9 26.5 39.7 43.0 47.1 12.3 30.3 61.2 49.5 49.5 49.4 36.8 38.3 37.9 72.7 126.4 16.8 10.6 51.6 30.5 88.1 33.2 46.7 43.2 78.0 39.2 14.0 44.8 28.0 20.6 8.5 14.2 29.4 49.5 28.6 87.5 25.3 50.6 26.8 43.2 20.1 26.3 27.1 26.0 49.6 31.0 16.0 14.8 66.9 32.2 24.4 44.3 29.6 KL ENSG00000133116 Klotho Q9UEF7 13 33016423-33066143 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins, Transporters" "Glycosidase, Hormone, Hydrolase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 47.1;kidney: 128.7;parathyroid gland: 135.2" "Cell type enriched" "Detected in some" 7 "Proximal tubular cells: 123.3" "Group enriched" "Detected in many" 6 "prostate cancer: 5.9;renal cancer: 17.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "HMC-1: 2.4;SK-BR-3: 4.5" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "basal ganglia: 13.3;cerebral cortex: 6.7;hippocampal formation: 7.4;medulla oblongata: 4.2" "Secreted to blood" NA NA 510000 "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "unprognostic (1.32e-1)" "unprognostic (3.10e-1)" "unprognostic (2.35e-1)" "unprognostic (2.73e-3)" "unprognostic (3.37e-1)" "unprognostic (1.15e-4)" "unprognostic (3.06e-2)" "unprognostic (6.50e-2)" "unprognostic (2.22e-2)" "unprognostic (2.60e-1)" "prognostic favorable (4.44e-4)" "unprognostic (9.46e-2)" "prognostic favorable (1.29e-9)" "unprognostic (4.76e-3)" "unprognostic (1.91e-1)" "unprognostic (2.86e-2)" "unprognostic (1.07e-1)" 3.3 1.4 0.9 0.8 3.1 0.1 2.5 0.8 1.5 1.8 47.1 2.1 2.7 1.2 8.8 1.1 0.8 1.3 1.1 4.2 1.1 128.7 0.4 3.5 1.0 0.5 0.5 0.1 1.2 135.2 0.3 30.4 0.5 8.0 0.9 0.0 0.8 2.5 0.7 0.6 2.6 1.2 0.6 2.4 2.0 0.5 0.8 0.5 1.3 1.5 0.5 1.6 0.6 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 4.5 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 3.1 0.8 1.5 4.2 1.1 0.5 0.5 0.5 0.6 0.8 0.5 15.8 0.0 0.5 0.0 0.6 0.1 0.2 0.0 0.0 0.0 0.6 0.3 1.0 0.0 0.7 12.9 0.0 0.2 0.0 0.4 5.9 0.0 1.8 0.1 2.5 10.2 16.3 0.4 1.2 0.0 0.1 1.6 0.0 0.1 0.0 0.1 1.1 0.2 2.8 0.0 0.5 1.1 0.0 0.9 1.0 0.8 0.3 1.9 0.0 6.5 0.9 0.0 0.0 0.0 0.2 0.0 0.0 0.4 0.0 3.6 1.8 123.3 0.7 0.0 0.0 1.1 2.3 1.4 0.5 0.0 0.1 0.1 1.1 0.1 1.9 0.1 LHPP HDHD2B ENSG00000107902 "Phospholysine phosphohistidine inorganic pyrophosphate phosphatase" Q9H008 10 124461823-124617888 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 198.8;choroid plexus: 104.0" "Cell type enhanced" "Detected in many" "Early spermatids: 114.9;Late spermatids: 163.3;Proximal tubular cells: 93.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA009163, HPA009269" Enhanced Supported "Nuclear speckles,Cytosol" NA NA 820000 "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 70: Brain - Nervous system development" "Cluster 3: HMC-1 - Innate immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nuclear speckles, Cytosol" "HPA009163: AB_1079250, HPA009269: AB_1079249" "unprognostic (3.46e-2)" "unprognostic (1.23e-2)" "unprognostic (4.78e-2)" "unprognostic (3.89e-1)" "unprognostic (2.14e-1)" "unprognostic (1.96e-1)" "unprognostic (5.77e-3)" "unprognostic (2.02e-2)" "unprognostic (3.58e-1)" "unprognostic (1.93e-1)" "unprognostic (6.42e-2)" "unprognostic (5.55e-2)" "unprognostic (1.79e-3)" "unprognostic (2.52e-1)" "unprognostic (2.10e-1)" "unprognostic (1.98e-1)" "unprognostic (1.64e-1)" 12.9 32.0 135.1 8.2 173.7 10.5 13.0 159.3 190.6 18.5 104.0 27.1 23.4 20.2 13.4 24.1 10.0 10.2 17.5 129.7 156.5 28.4 60.2 9.2 11.8 179.2 165.8 9.0 15.9 9.2 14.5 8.6 170.7 14.0 8.5 7.5 18.3 12.5 10.2 15.3 21.1 10.2 151.1 14.0 20.1 24.2 156.3 9.7 29.4 4.8 15.2 14.7 16.1 198.8 24.7 12.0 4.7 12.1 18.2 14.7 12.8 8.2 18.0 5.5 10.0 2.1 22.4 24.4 19.7 13.5 6.1 26.1 1.4 4.7 5.7 5.4 16.3 17.6 4.1 11.4 18.5 3.6 27.6 11.0 20.0 5.4 13.0 16.0 8.8 21.4 8.9 9.5 6.9 24.5 12.0 11.3 8.5 10.4 6.8 12.4 5.3 31.8 12.1 3.2 2.7 14.2 6.3 22.6 8.2 6.5 17.2 0.6 4.2 8.5 12.2 7.2 2.3 7.9 2.5 7.8 7.7 6.8 2.0 8.1 28.8 25.3 16.1 24.5 20.8 41.0 18.7 17.2 35.6 43.3 22.4 16.0 4.8 7.9 29.0 13.4 32.1 24.4 135.1 173.7 159.3 190.6 129.7 156.5 179.2 165.8 170.7 151.1 156.3 198.8 5.0 3.2 14.8 22.9 29.1 7.4 9.4 22.1 13.1 6.0 19.8 19.8 15.8 12.8 19.4 7.3 0.0 54.2 6.2 17.9 33.2 5.3 114.9 17.7 12.7 4.6 9.5 19.8 29.4 2.3 24.7 11.2 19.9 8.2 10.8 23.3 6.1 61.1 26.5 11.8 27.8 21.3 24.4 16.0 8.1 163.3 5.9 12.9 17.8 8.4 15.6 9.8 8.2 15.6 76.4 3.3 30.2 10.5 19.7 6.7 80.5 93.8 24.9 6.4 13.1 5.2 9.5 33.1 11.3 30.7 5.4 24.2 12.1 12.4 23.0 16.3 LPO SPO ENSG00000167419 Lactoperoxidase P22079 17 58218548-58268518 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrogen peroxide" "Antimicrobial, Oxidoreductase, Peroxidase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 404 "salivary gland: 1026.8" "Group enriched" "Detected in some" 6 "Breast glandular cells: 25.2;Early spermatids: 8.3;Late spermatids: 14.1" "Not detected" "Not detected" "Region enriched" "Detected in single" 4 "midbrain: 2.5" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 10 "THP-1: 9.9" "Low region specificity" "Detected in many" "Not detected" "Not detected" HPA028688 Enhanced Supported "Secreted to digestive system" NA NA "Cluster 24: Salivary gland - Salivary secretion" "Cluster 43: THP-1 - Innate immune response" "Cluster 30: Mammary glandular cells - Lactation" "HPA028688: AB_10601909" "unprognostic (2.74e-1)" "unprognostic (5.12e-2)" "unprognostic (4.14e-3)" "unprognostic (1.56e-3)" "unprognostic (2.41e-2)" "unprognostic (9.71e-2)" "unprognostic (2.06e-2)" "unprognostic (1.53e-1)" "unprognostic (2.40e-2)" "unprognostic (6.27e-3)" "unprognostic (6.32e-2)" "unprognostic (2.56e-1)" "unprognostic (0.00e+0)" "unprognostic (3.41e-2)" "unprognostic (3.15e-1)" "unprognostic (2.72e-2)" "unprognostic (1.22e-1)" 0.0 0.0 0.1 0.0 0.0 0.6 0.0 0.1 0.1 0.4 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.1 0.3 0.0 0.0 0.0 0.0 0.0 2.5 0.0 1.2 0.0 0.0 0.1 0.0 0.0 0.0 0.1 1026.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 9.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.1 0.3 0.0 2.5 0.0 0.0 0.5 0.1 0.2 0.0 0.0 0.0 0.0 0.3 0.7 0.0 0.0 0.7 25.2 0.5 0.7 0.0 0.6 0.0 0.0 0.0 0.3 0.0 0.0 0.1 8.3 0.3 0.1 0.3 0.0 0.0 0.6 0.0 0.0 0.2 0.0 0.1 1.3 0.0 0.4 0.0 0.2 1.7 0.3 0.0 0.0 0.0 0.0 14.1 0.3 0.1 0.0 0.0 0.6 0.0 0.0 0.0 0.1 0.3 0.0 0.4 0.0 0.5 1.4 0.1 0.0 0.3 0.0 0.2 0.1 2.6 0.4 0.0 0.3 0.0 0.2 0.0 0.5 0.5 MPO ENSG00000005381 Myeloperoxidase P05164 17 58269855-58280935 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrogen peroxide" "Oxidoreductase, Peroxidase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 61 "bone marrow: 4023.1" "Cell type enriched" "Detected in some" 30 "Erythroid cells: 87.4" "Cancer enhanced" "Detected in single" "stomach cancer: 1.1" "Low region specificity" "Detected in some" "Immune cell enhanced" "Detected in some" "classical monocyte: 6.2" "Low lineage specificity" "Detected in many" "Group enriched" "Detected in some" 94 "HL-60: 3517.4;NB-4: 4589.9" "Not detected" "Not detected" "Not detected" "Not detected" "CAB000059, HPA021147, HPA061464" Enhanced Supported Nucleoplasm,Vesicles "Intracellular and membrane" No NA 576000000 24000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 24: NB-4 - Immune response" "Cluster 12: Non-specific - Cell cycle regulation" Vesicles Nucleoplasm "CAB000059: AB_2335676, HPA021147: AB_1854083, HPA061464: AB_2684531" "unprognostic (1.91e-1)" "unprognostic (9.08e-2)" "unprognostic (4.62e-2)" "unprognostic (2.90e-2)" "unprognostic (2.13e-3)" "unprognostic (2.78e-1)" "unprognostic (3.23e-1)" "unprognostic (2.91e-1)" "unprognostic (2.56e-1)" "unprognostic (1.68e-1)" "unprognostic (6.92e-2)" "unprognostic (8.34e-3)" "unprognostic (4.91e-2)" "unprognostic (3.07e-3)" "unprognostic (2.83e-1)" "unprognostic (1.14e-2)" "unprognostic (8.05e-2)" 0.5 0.4 0.8 0.6 0.6 4023.1 0.3 0.6 1.1 0.0 0.3 0.2 0.0 0.2 1.1 0.1 0.1 0.3 1.1 0.8 0.7 0.2 1.8 8.4 1.7 0.9 1.0 0.1 0.1 0.0 1.5 1.4 0.9 0.2 0.2 0.4 66.3 0.1 1.1 4.3 0.2 0.3 0.8 21.7 0.1 0.4 0.8 10.9 0.3 0.3 0.2 0.5 0.1 0.7 0.4 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.1 3517.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4589.9 0.0 0.0 0.0 5.3 3.2 0.6 0.0 0.0 0.0 0.5 1.1 0.0 0.0 0.0 0.0 43.1 0.0 0.0 0.0 1.3 0.0 0.0 0.0 1.1 0.0 4.0 0.0 0.0 6.2 0.0 0.0 3.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 1.4 0.0 0.6 0.0 0.1 7.5 0.8 0.6 0.6 1.1 0.8 0.7 0.9 1.0 0.9 0.8 0.8 0.7 0.0 0.0 0.5 0.7 0.3 0.0 0.0 0.0 0.0 0.4 0.2 0.3 0.4 0.0 0.0 0.0 0.0 0.0 1.8 0.0 1.9 0.0 0.5 0.1 0.0 0.1 0.0 87.4 0.3 0.2 0.9 0.7 0.0 0.0 0.0 0.0 0.7 0.3 0.9 0.0 0.2 0.0 0.0 1.2 0.0 1.3 0.0 2.9 0.0 0.0 2.3 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.2 0.0 1.2 0.1 0.1 0.3 0.1 0.0 0.1 0.6 0.0 0.0 0.0 NAE1 "APP-BP1, APPBP1, ula-1" ENSG00000159593 "NEDD8 activating enzyme E1 subunit 1" Q13564 16 66802875-66873256 "Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle, Ubl conjugation pathway" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatogonia: 219.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041178, HPA042041" Enhanced Approved Nucleoplasm,Microtubules,Centrosome NA NA 100000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" Nucleoplasm "Microtubules, Centrosome" "HPA041178: AB_10964773, HPA042041: AB_10964772" "unprognostic (3.22e-2)" "unprognostic (1.73e-1)" "unprognostic (1.79e-2)" "unprognostic (1.13e-1)" "unprognostic (2.00e-2)" "unprognostic (1.06e-2)" "prognostic unfavorable (3.92e-8)" "unprognostic (2.31e-1)" "unprognostic (5.58e-2)" "unprognostic (3.12e-3)" "unprognostic (5.34e-2)" "unprognostic (3.85e-2)" "unprognostic (7.09e-3)" "unprognostic (2.50e-1)" "unprognostic (1.84e-1)" "prognostic favorable (9.44e-5)" "unprognostic (1.97e-1)" 23.9 28.3 26.0 26.0 26.0 38.8 32.5 28.8 29.6 23.0 27.1 31.9 32.4 32.9 35.2 30.3 26.8 24.2 29.7 25.5 27.1 26.5 28.6 22.5 36.1 25.8 26.1 35.6 27.3 41.5 22.6 28.4 27.1 28.8 35.3 33.9 25.9 26.7 35.0 33.1 33.2 30.3 27.0 22.2 21.6 47.1 27.1 35.0 32.3 33.0 31.6 28.6 22.1 30.3 107.6 81.1 140.4 139.4 55.1 78.9 116.9 79.9 80.3 115.6 139.8 99.5 80.9 118.1 89.1 60.4 74.8 105.6 107.7 96.5 162.0 43.8 122.1 83.9 53.6 153.9 63.2 157.3 100.7 64.0 69.6 92.8 80.7 61.0 82.5 141.2 201.9 40.3 89.9 37.5 165.7 177.7 196.2 83.4 144.6 175.7 167.8 157.7 89.1 92.6 151.3 110.6 239.5 50.7 94.7 86.0 54.2 105.2 64.7 80.2 80.1 84.7 93.9 75.3 125.3 423.8 72.3 103.0 99.7 2.8 6.0 13.4 27.3 5.8 34.9 18.2 29.0 30.1 8.2 14.4 31.0 31.4 2.7 17.1 6.5 12.2 27.4 18.3 26.0 26.0 28.8 29.6 25.5 27.1 25.8 26.1 27.1 27.0 27.1 30.3 29.2 32.1 32.2 23.5 30.1 33.0 66.6 87.2 17.1 52.0 28.4 31.4 30.7 18.6 53.4 31.3 12.5 101.3 33.9 28.0 39.2 70.0 4.6 27.7 23.2 30.7 22.9 38.9 41.3 60.2 70.9 38.4 20.9 22.9 35.4 55.9 19.2 21.3 28.6 50.5 40.7 33.3 67.1 10.4 13.5 14.3 48.7 16.2 49.8 17.8 25.7 68.4 51.5 33.2 39.8 65.0 114.3 54.2 32.0 68.8 34.7 48.2 44.8 35.9 19.7 41.0 63.7 145.4 219.3 33.6 32.1 52.4 36.9 49.4 42.5 49.5 NLN "AGTBP, KIAA1226" ENSG00000123213 Neurolysin Q9BYT8 5 65722205-65871725 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 52.8;Excitatory neurons: 58.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 5 "classical monocyte: 2.6;intermediate monocyte: 3.4;myeloid DC: 2.2;non-classical monocyte: 2.3" "Group enriched" "Detected in many" 5 "dendritic cells: 2.2;monocytes: 3.4" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031862 Approved Approved Mitochondria Yes No 64000 "Cluster 7: Monocytes - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 25: RPMI-8226 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Mitochondria "HPA031862: AB_10600827" "unprognostic (5.91e-3)" "unprognostic (4.52e-2)" "unprognostic (1.34e-3)" "unprognostic (4.37e-2)" "unprognostic (3.85e-1)" "unprognostic (1.45e-2)" "unprognostic (7.29e-3)" "unprognostic (3.24e-2)" "unprognostic (3.19e-1)" "unprognostic (3.58e-1)" "prognostic unfavorable (7.51e-4)" "unprognostic (1.27e-1)" "prognostic favorable (5.58e-7)" "unprognostic (1.52e-2)" "unprognostic (1.98e-1)" "unprognostic (1.29e-1)" "unprognostic (6.18e-3)" 2.2 1.0 3.8 2.4 3.9 1.5 3.7 2.9 5.3 1.8 1.6 3.6 1.1 2.7 2.4 2.5 1.5 1.2 2.6 3.8 3.6 3.9 9.9 1.7 1.7 3.9 3.4 1.8 2.5 1.5 0.9 2.4 4.0 2.6 3.2 2.5 1.9 1.1 8.9 2.8 2.7 2.7 3.3 1.3 4.0 1.1 3.9 0.9 2.7 6.5 2.0 2.7 1.5 4.8 13.3 12.5 7.2 12.0 9.0 15.3 14.5 13.1 5.5 7.6 8.2 7.2 7.7 18.8 16.1 15.8 15.1 10.3 9.5 20.2 13.1 5.6 6.4 5.2 8.7 18.5 7.7 12.0 3.0 11.7 10.8 10.5 12.4 6.3 21.7 8.3 11.4 3.9 16.5 10.2 8.3 10.8 22.2 6.7 3.6 9.6 15.3 29.9 12.6 5.9 22.3 11.5 10.6 10.7 11.0 19.4 12.9 14.1 12.5 5.0 5.9 7.4 10.0 3.3 7.1 8.2 7.7 23.2 7.7 0.1 2.6 0.1 0.1 3.4 0.1 0.4 0.2 0.1 2.2 0.4 0.3 0.2 0.3 0.5 2.3 0.1 0.0 1.0 3.8 3.9 2.9 5.3 3.8 3.6 3.9 3.4 4.0 3.3 3.9 4.8 5.9 6.4 2.8 19.6 4.0 5.7 9.0 6.2 8.6 2.4 10.1 8.9 14.5 7.2 8.5 12.9 4.2 5.3 0.6 52.8 5.9 17.8 0.3 7.4 12.9 8.3 1.8 9.0 58.9 14.5 14.0 7.1 20.4 20.9 15.2 16.2 4.6 32.4 28.8 5.0 32.2 5.8 6.1 22.9 8.9 0.4 4.4 13.5 1.8 5.6 17.9 13.1 2.1 22.6 44.5 30.2 35.9 2.2 4.9 16.5 32.3 22.4 3.1 4.7 0.0 19.7 8.1 2.1 5.2 15.3 5.3 2.9 2.3 15.8 8.2 6.1 PPA1 "IOPPP, PP, PP1, Ppase, SID6-8061" ENSG00000180817 "Inorganic pyrophosphatase 1" Q15181 10 70202835-70233911 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Muller glia cells: 1239.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019878, HPA020096" Supported Supported Vesicles NA NA 1000000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 30: Epithelial cell lines - Translation" "Cluster 5: Muller glia cells - Visual perception" Vesicles "HPA019878: AB_1855601, HPA020096: AB_1855600" "unprognostic (1.50e-1)" "unprognostic (2.85e-1)" "unprognostic (4.71e-2)" "unprognostic (2.85e-1)" "unprognostic (1.42e-1)" "unprognostic (4.47e-2)" "unprognostic (2.86e-2)" "unprognostic (9.43e-2)" "unprognostic (3.34e-1)" "unprognostic (1.62e-1)" "unprognostic (2.13e-2)" "unprognostic (3.60e-2)" "unprognostic (1.82e-3)" "unprognostic (5.36e-2)" "unprognostic (2.37e-1)" "unprognostic (3.53e-2)" "unprognostic (2.74e-1)" 176.7 198.5 124.3 116.0 138.8 85.0 186.7 166.7 163.0 96.5 123.0 137.3 99.4 85.8 166.7 157.7 110.2 90.3 100.1 125.8 148.5 123.2 150.2 129.0 132.6 153.1 142.3 56.5 188.5 68.5 92.1 103.7 165.4 68.7 152.5 332.0 116.1 78.7 133.0 85.9 125.1 96.8 159.3 64.2 97.5 73.5 141.6 103.5 126.3 137.3 137.3 167.1 140.0 167.0 446.9 181.2 158.8 471.2 421.6 368.8 148.2 163.5 305.3 250.1 261.8 556.7 230.6 641.0 144.5 164.0 162.8 351.2 470.7 318.4 253.8 599.1 443.5 176.1 169.1 321.7 265.8 439.0 106.9 244.2 372.9 201.3 530.7 273.8 307.9 319.2 416.9 336.4 239.4 262.3 426.5 408.7 165.9 614.2 494.8 256.9 181.7 378.2 527.0 276.3 474.4 159.6 179.3 694.5 148.0 110.8 174.3 194.2 141.0 69.0 262.2 229.4 315.2 110.1 259.2 469.8 106.7 605.2 62.0 0.4 68.8 1.7 48.9 55.2 131.1 83.6 112.3 85.6 190.0 59.4 122.7 106.8 4.1 65.8 63.1 44.4 120.4 105.3 124.3 138.8 166.7 163.0 125.8 148.5 153.1 142.3 165.4 159.3 141.6 167.0 207.0 224.4 165.9 17.0 122.7 267.9 366.2 427.3 158.2 184.9 347.8 363.7 93.3 218.8 275.7 108.5 173.0 313.2 63.4 203.3 201.5 540.1 31.7 278.8 196.1 182.1 162.7 88.4 36.8 776.1 298.3 156.9 114.2 512.1 36.8 208.2 38.2 141.8 96.5 85.8 41.2 254.9 160.7 80.1 148.1 31.7 109.6 120.3 181.5 29.0 612.7 1239.0 65.9 21.6 98.4 532.9 213.5 117.4 161.2 512.4 444.5 551.2 92.1 278.4 65.7 97.2 136.8 173.7 170.7 245.8 257.1 245.7 120.9 203.0 347.6 613.9 PPA2 FLJ20459 ENSG00000138777 "Inorganic pyrophosphatase 2" Q9H2U2 4 105369077-105474067 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Hydrolase "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030888, HPA031671, HPA031672" Supported Approved Mitochondria NA NA 150000 "Cluster 44: Non-specific - Transcription" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "HPA030888: AB_2673646, HPA031671: AB_10603986, HPA031672: AB_2673988" "prognostic unfavorable (2.98e-4)" "unprognostic (5.64e-2)" "prognostic favorable (6.60e-4)" "unprognostic (9.26e-3)" "unprognostic (2.93e-2)" "unprognostic (5.10e-2)" "unprognostic (1.15e-1)" "unprognostic (2.44e-1)" "unprognostic (1.50e-1)" "unprognostic (1.20e-1)" "unprognostic (7.05e-2)" "unprognostic (9.54e-2)" "prognostic favorable (1.27e-11)" "unprognostic (3.69e-1)" "unprognostic (1.94e-1)" "unprognostic (2.00e-1)" "unprognostic (1.10e-1)" 7.4 12.8 23.8 9.0 24.6 22.0 12.0 24.3 53.7 7.4 29.5 17.4 14.2 7.4 12.5 10.8 8.4 8.0 27.5 23.7 26.3 20.7 14.8 7.5 8.3 24.4 24.3 5.8 11.8 11.7 7.7 7.4 24.5 13.3 14.0 13.6 13.8 5.7 27.6 12.2 13.8 6.8 24.0 9.9 12.6 6.3 25.4 7.0 11.5 35.5 8.7 8.1 6.7 26.6 20.6 8.5 18.5 32.3 11.3 9.1 12.9 10.2 15.7 14.6 9.9 22.2 30.4 15.6 14.5 9.7 11.3 9.5 39.2 18.7 17.0 23.6 11.8 13.5 13.7 19.9 9.3 36.7 13.6 9.7 19.6 9.9 7.9 15.4 14.6 28.4 22.3 22.0 12.5 26.2 32.5 26.6 13.9 42.4 28.3 28.2 10.9 17.9 49.7 14.7 17.8 10.7 7.8 48.9 19.0 10.7 24.8 32.1 6.9 9.2 19.2 8.9 20.0 19.0 27.3 18.4 17.5 18.6 14.1 27.0 20.9 15.4 21.0 30.1 18.6 28.5 21.7 23.7 49.9 22.6 21.1 23.9 9.5 36.4 26.4 25.9 23.4 23.5 23.8 24.6 24.3 53.7 23.7 26.3 24.4 24.3 24.5 24.0 25.4 26.6 26.7 9.6 67.3 86.2 37.6 50.0 82.4 205.0 38.1 29.7 64.8 40.9 63.3 45.8 126.2 33.1 16.7 119.0 25.9 73.3 264.1 114.0 113.7 42.3 35.3 36.3 65.7 70.2 138.2 120.1 98.5 31.1 37.2 42.3 45.6 26.4 24.3 64.2 83.5 21.9 134.6 104.6 142.4 42.9 86.1 126.4 27.7 47.1 76.5 74.9 50.5 39.2 30.9 169.9 145.7 65.0 90.4 32.4 41.9 68.1 112.2 285.4 90.7 22.6 39.5 46.3 43.6 50.8 10.8 59.1 57.7 84.7 34.3 72.1 138.0 94.6 PRDX6 "1-Cys, aiPLA2, AOP2, KIAA0106, MGC46173, NSGPx, p29, PRX" ENSG00000117592 "Peroxiredoxin 6" P30041 1 173477330-173488815 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Lipid degradation, Lipid metabolism" "Antioxidant, Hydrolase, Multifunctional enzyme, Oxidoreductase, Peroxidase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 1315.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006983, CAB008663" Supported Supported "Plasma membrane,Cytosol" NA NA 120000000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 39: Non-specific - Mitochondria" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane, Cytosol" "CAB008663: AB_1620994, HPA006983: AB_1079595" "unprognostic (9.92e-2)" "unprognostic (1.50e-1)" "unprognostic (3.67e-1)" "unprognostic (2.99e-3)" "unprognostic (1.96e-1)" "prognostic unfavorable (1.23e-5)" "unprognostic (5.71e-3)" "unprognostic (2.80e-2)" "unprognostic (5.27e-3)" "unprognostic (3.96e-3)" "unprognostic (3.19e-3)" "unprognostic (1.59e-1)" "prognostic unfavorable (9.51e-4)" "unprognostic (2.50e-1)" "unprognostic (7.12e-2)" "unprognostic (1.15e-1)" "unprognostic (4.73e-3)" 340.7 157.5 169.5 68.3 181.3 100.1 211.2 197.6 210.1 112.3 164.8 189.1 46.4 108.8 206.3 127.9 149.8 71.9 261.8 184.1 196.6 184.4 482.5 116.7 72.2 181.0 198.3 115.5 114.4 217.5 67.4 70.7 187.5 152.1 221.6 53.9 85.6 99.0 563.5 106.6 59.8 160.2 175.8 70.7 135.2 119.1 176.7 70.7 106.0 382.4 79.0 99.5 109.8 185.5 420.3 127.7 204.7 230.9 778.5 372.7 169.5 843.9 284.3 342.7 241.8 243.9 276.4 272.4 256.4 694.2 120.4 239.8 272.0 259.9 279.0 234.0 243.6 179.5 200.0 277.7 425.7 191.3 56.1 301.0 262.6 181.3 256.6 210.8 339.5 106.7 405.4 52.8 392.9 86.3 131.7 249.1 456.2 219.8 760.5 154.5 236.6 277.0 518.1 95.4 94.9 173.4 285.0 334.0 199.2 296.3 283.8 262.9 228.2 132.5 149.9 201.8 229.5 76.4 123.2 220.7 159.4 162.3 124.3 36.2 42.5 24.8 29.8 39.8 32.8 32.6 29.8 38.4 53.5 24.4 39.8 47.9 25.2 25.7 36.5 79.7 36.1 58.1 169.5 181.3 197.6 210.1 184.1 196.6 181.0 198.3 187.5 175.8 176.7 185.5 278.1 176.3 170.8 127.3 127.4 235.4 404.1 382.8 209.5 31.9 186.1 250.7 528.6 301.7 228.6 277.7 29.2 714.3 158.6 1315.9 860.8 178.6 237.5 206.9 226.8 191.8 142.1 449.5 13.8 202.3 939.1 307.0 111.6 200.0 348.6 216.6 214.2 1120.2 345.0 45.4 13.2 257.4 205.4 164.3 161.0 667.5 340.5 227.1 183.2 17.8 212.9 462.5 83.4 12.5 15.4 147.2 663.4 416.8 176.4 427.1 264.4 827.3 209.1 52.0 184.1 185.7 253.8 123.5 76.8 305.9 264.1 963.5 157.7 512.5 303.6 308.9 PRUNE1 "DRES-17, H-PRUNE, HTCD37, PRUNE" ENSG00000143363 "Prune exopolyphosphatase 1" Q86TP1 1 151008420-151035713 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Hydrolase "Disease variant, Mental retardation, Neurodegeneration, Primary microcephaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 13.0;Breast glandular cells: 9.8;Breast myoepithelial cells: 8.9;Collecting duct cells: 11.0;Granulosa cells: 8.9;Proximal tubular cells: 8.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 169.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA028411 Uncertain Supported Cytosol NA NA 41000 "Cluster 5: Granulocytes - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 7: Non-specific - Mitochondria" Cytosol "HPA028411: AB_10603229" "unprognostic (6.24e-2)" "unprognostic (2.24e-1)" "unprognostic (4.17e-2)" "prognostic unfavorable (3.86e-4)" "unprognostic (6.91e-2)" "unprognostic (2.02e-1)" "unprognostic (2.12e-3)" "unprognostic (7.05e-2)" "unprognostic (4.08e-2)" "unprognostic (5.92e-2)" "unprognostic (1.73e-1)" "unprognostic (2.65e-1)" "prognostic unfavorable (3.48e-4)" "unprognostic (2.18e-1)" "unprognostic (3.21e-2)" "unprognostic (2.42e-2)" "unprognostic (1.36e-1)" 10.1 9.5 12.2 7.7 12.1 4.4 14.9 16.1 15.1 15.0 12.4 14.8 12.5 14.8 15.6 12.4 16.0 9.2 33.4 12.4 12.6 18.8 14.3 10.8 10.8 12.0 12.5 17.2 10.7 20.9 12.6 7.1 11.9 12.2 14.5 10.8 13.2 14.4 29.4 11.5 12.0 14.1 11.9 11.2 11.2 18.3 12.8 16.2 32.5 21.4 12.6 13.7 11.9 13.5 11.0 11.6 20.2 19.3 24.3 6.6 10.9 5.1 11.2 18.7 16.4 14.1 13.0 22.2 21.7 6.9 5.5 15.5 19.9 13.4 14.6 24.5 22.6 26.6 11.8 20.4 13.5 17.5 13.0 8.4 24.7 10.2 9.5 15.4 9.2 29.4 21.1 18.3 8.9 26.2 27.2 14.1 18.7 39.7 15.0 24.2 12.8 21.5 13.4 14.9 28.7 23.5 17.5 23.5 16.1 28.3 32.6 25.7 6.3 6.6 7.8 7.5 8.1 44.1 40.0 169.1 6.5 13.0 16.9 19.1 8.1 17.8 16.4 7.8 19.8 14.4 18.1 18.6 11.9 15.4 21.7 17.5 18.6 18.8 12.2 6.4 18.5 22.3 12.2 12.1 16.1 15.1 12.4 12.6 12.0 12.5 11.9 11.9 12.8 13.5 4.5 6.4 13.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 9.8 8.9 0.0 0.0 3.1 11.0 0.0 4.1 3.2 0.0 0.0 6.0 0.0 4.3 7.8 2.1 0.0 0.0 0.0 5.7 4.8 2.5 0.0 6.4 0.0 8.9 0.0 0.0 5.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 1.6 0.0 0.0 0.0 0.0 5.6 0.0 0.0 1.0 0.0 0.0 8.9 2.9 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.0 5.1 2.8 4.8 0.0 0.0 PXDN "D2S448, D2S448E, KIAA0230, MG50, PRG2, PXN" ENSG00000130508 Peroxidasin Q92626 2 1631887-1744852 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Hydrogen peroxide" "Oxidoreductase, Peroxidase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Adipocytes: 79.1;Endometrial stromal cells: 99.4;Endothelial cells: 95.1;Hepatic stellate cells: 71.4;Skeletal myocytes: 120.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "EFO-21: 323.8" "Low region specificity" "Detected in all" "Not detected" "Not detected" HPA012375 Approved "Secreted to extracellular matrix" NA NA 9100000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 46: Fibroblasts - ECM organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "HPA012375: AB_1855965" "unprognostic (4.37e-2)" "prognostic unfavorable (6.28e-4)" "unprognostic (2.08e-1)" "prognostic unfavorable (2.75e-4)" "unprognostic (8.16e-3)" "unprognostic (1.91e-1)" "unprognostic (1.92e-2)" "unprognostic (3.15e-3)" "unprognostic (6.50e-3)" "unprognostic (1.34e-2)" "unprognostic (6.78e-2)" "unprognostic (2.23e-1)" "unprognostic (6.13e-3)" "prognostic unfavorable (6.73e-4)" "unprognostic (1.18e-1)" "unprognostic (7.33e-3)" "unprognostic (5.54e-3)" 59.5 5.5 4.1 24.3 3.5 0.9 33.7 1.9 4.1 18.2 27.5 36.1 7.9 32.8 4.0 4.9 18.0 22.7 22.7 3.1 7.7 9.0 12.4 27.6 5.0 4.2 6.2 32.7 3.8 3.0 11.7 33.4 4.7 17.5 8.7 5.2 13.6 11.1 7.7 6.9 16.3 61.8 2.6 10.0 13.2 6.4 5.2 2.1 8.4 11.5 2.1 33.8 13.5 3.4 39.9 13.9 72.0 0.1 198.3 180.9 54.6 231.4 182.3 99.0 107.9 0.1 0.5 0.0 323.8 230.3 4.5 8.3 0.3 142.3 125.5 0.6 2.4 0.0 139.3 0.0 196.4 0.6 0.0 200.7 41.0 112.2 83.8 299.5 247.0 35.9 0.1 0.0 142.6 23.6 6.8 8.0 58.3 0.0 52.3 13.2 250.8 0.6 115.9 0.1 0.2 131.9 0.2 73.6 0.4 142.9 27.0 0.9 242.4 162.8 79.7 6.2 180.7 0.2 205.4 1.0 0.8 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 4.1 3.5 1.9 4.1 3.1 7.7 4.2 6.2 4.7 2.6 5.2 3.4 79.1 6.4 2.3 2.6 0.4 2.9 2.8 12.8 0.6 2.5 17.5 14.1 5.8 17.2 7.0 1.8 0.0 0.6 0.2 0.3 0.0 10.4 33.4 4.2 99.4 95.1 1.8 0.0 6.6 0.0 11.3 45.2 0.0 3.4 1.3 43.7 71.4 1.8 1.9 0.0 7.3 1.3 20.3 5.7 4.4 40.7 26.8 0.7 7.2 8.4 0.6 10.0 1.0 55.8 0.7 0.5 0.1 15.1 0.0 14.0 0.0 0.2 6.7 0.8 46.0 120.1 51.1 22.0 16.0 0.5 2.8 1.4 1.0 33.3 0.5 1.4 PXDNL "FLJ25471, PMR1" ENSG00000147485 "Peroxidasin like" A1KZ92 8 51319577-51809445 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrogen peroxide" "Endonuclease, Hydrolase, Nuclease, Oxidoreductase, Peroxidase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "heart muscle: 45.3" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 42.2;Early spermatids: 43.8;Excitatory neurons: 25.2;Inhibitory neurons: 68.8;Microglial cells: 16.9;Muller glia cells: 18.6;Spermatocytes: 24.2" "Group enriched" "Detected in some" 4 "breast cancer: 1.7;glioma: 0.7;renal cancer: 0.8;testis cancer: 1.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "AF22: 7.7;Daudi: 5.9;SH-SY5Y: 6.1" HPA007919 Approved Nucleoplasm,Cytosol "Intracellular and membrane" NA NA "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Cytosol" "HPA007919: AB_1855966" "prognostic unfavorable (3.27e-5)" "unprognostic (4.59e-4)" "unprognostic (5.57e-3)" "unprognostic (2.83e-3)" "unprognostic (2.71e-1)" "unprognostic (5.14e-2)" "unprognostic (1.18e-1)" "unprognostic (7.18e-3)" "unprognostic (1.85e-1)" "unprognostic (1.15e-1)" "unprognostic (7.07e-2)" "unprognostic (1.07e-1)" "unprognostic (2.60e-4)" "unprognostic (2.28e-2)" "unprognostic (3.35e-2)" "unprognostic (2.42e-2)" "unprognostic (2.97e-4)" 1.6 0.1 0.2 0.2 0.1 0.0 0.2 0.2 0.6 0.1 0.0 0.1 0.0 0.1 9.4 0.2 0.0 0.1 45.3 0.2 0.3 1.6 0.0 0.2 0.3 0.5 0.6 0.1 0.0 0.2 0.0 0.0 0.8 0.2 0.1 2.9 0.3 0.0 1.4 0.2 0.2 0.0 0.1 0.4 0.0 5.0 0.2 0.5 0.3 2.1 0.5 0.0 0.0 0.4 0.5 0.0 7.7 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 5.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 6.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.2 0.6 0.2 0.3 0.5 0.6 0.8 0.1 0.2 0.4 0.3 0.0 0.0 10.7 0.0 0.1 0.1 0.0 0.0 1.2 3.7 0.1 42.2 0.0 0.0 0.0 0.0 0.0 1.5 0.0 1.9 0.0 43.8 0.0 0.0 0.3 0.0 0.0 25.2 0.0 0.0 5.3 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 68.8 0.0 0.0 0.0 0.0 6.3 0.0 0.1 0.0 16.9 0.0 18.6 0.0 14.1 14.9 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.6 0.0 0.2 0.8 24.2 1.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 RRM1 ENSG00000167325 "Ribonucleotide reductase catalytic subunit M1" P23921 11 4094707-4138932 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA replication" "Allosteric enzyme, Oxidoreductase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 102.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022093, HPA057265, HPA064297" Enhanced Supported Cytosol NA Yes 140000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Cytosol "CAB022093: , HPA057265: AB_2683386, HPA064297: AB_2685236" "unprognostic (4.47e-2)" "unprognostic (1.73e-2)" "unprognostic (1.99e-3)" "unprognostic (3.65e-1)" "unprognostic (2.83e-1)" "unprognostic (2.19e-1)" "prognostic unfavorable (1.53e-4)" "unprognostic (1.31e-2)" "unprognostic (3.43e-2)" "unprognostic (6.90e-2)" "unprognostic (1.06e-3)" "unprognostic (4.21e-2)" "unprognostic (6.88e-3)" "unprognostic (9.20e-3)" "unprognostic (6.16e-2)" "unprognostic (8.41e-2)" "unprognostic (9.93e-3)" 16.6 21.2 5.1 24.8 5.3 32.8 22.7 7.1 6.1 16.9 4.7 25.7 19.3 16.2 10.1 26.5 15.5 11.8 16.4 5.1 5.7 13.4 18.4 12.8 34.4 6.1 5.5 16.4 14.6 24.7 7.1 20.4 6.6 18.5 29.4 23.6 14.7 16.0 30.3 36.1 20.2 20.1 6.2 13.0 17.6 17.9 5.1 56.7 15.6 30.0 45.2 15.6 18.9 6.2 221.6 117.8 188.4 110.0 28.4 56.2 73.0 198.0 98.2 220.7 225.9 106.8 163.8 237.4 47.0 100.1 95.9 173.0 176.9 143.2 259.3 117.3 187.9 121.0 159.8 83.1 11.2 208.9 84.6 26.6 37.8 121.7 86.4 48.3 107.8 140.1 161.1 107.3 186.8 99.6 246.7 41.9 118.2 152.2 119.2 196.1 147.0 84.3 59.4 61.8 159.8 88.1 175.1 104.8 30.0 75.8 102.8 71.4 62.3 203.4 106.0 206.9 147.4 70.3 103.5 252.5 114.1 137.6 130.3 8.3 4.0 4.5 11.3 11.2 21.1 9.2 22.3 16.6 7.3 5.2 17.2 15.0 0.0 10.5 15.6 4.4 41.7 10.3 5.1 5.3 7.1 6.1 5.1 5.7 6.1 5.5 6.6 6.2 5.1 6.2 12.4 19.2 14.4 4.9 17.0 33.4 26.8 31.0 17.6 15.6 15.1 14.4 33.5 14.3 24.7 18.4 6.2 62.8 14.9 13.3 7.9 25.6 69.9 11.5 14.5 15.7 18.0 81.2 11.2 22.2 62.5 22.0 20.4 13.9 7.0 27.3 10.8 15.0 28.3 18.5 12.0 25.0 16.2 11.7 10.3 83.9 13.1 13.9 10.6 6.5 10.7 24.0 5.2 12.1 11.9 15.8 10.4 16.6 31.3 10.1 12.5 8.4 15.5 22.7 13.1 19.5 27.1 102.8 63.1 36.5 29.0 39.7 23.2 18.1 34.3 20.6 RRM2 "C2orf48, FLJ25102" ENSG00000171848 "Ribonucleotide reductase regulatory subunit M2" P31350 2 10120698-10211725 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "DNA replication" Oxidoreductase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "bone marrow: 44.2;esophagus: 18.4;intestine: 19.7;lymphoid tissue: 58.1" "Group enriched" "Detected in many" 4 "Erythroid cells: 214.0;Extravillous trophoblasts: 254.1;Plasma cells: 248.0" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056994 Enhanced Supported Cytosol Yes Yes 13000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Cytosol "HPA056994: AB_2683304" "unprognostic (2.10e-2)" "unprognostic (1.62e-1)" "unprognostic (6.40e-3)" "unprognostic (4.42e-3)" "unprognostic (5.70e-2)" "unprognostic (1.69e-1)" "prognostic unfavorable (1.39e-5)" "unprognostic (1.04e-3)" "unprognostic (6.67e-3)" "unprognostic (4.53e-2)" "prognostic unfavorable (1.62e-4)" "unprognostic (5.11e-3)" "prognostic unfavorable (0.00e+0)" "unprognostic (3.05e-2)" "unprognostic (2.24e-1)" "unprognostic (1.38e-1)" "unprognostic (2.09e-2)" 1.5 1.3 0.3 12.4 0.3 44.2 2.9 0.5 0.4 3.0 1.9 14.2 9.4 2.2 0.7 18.4 0.8 1.1 0.5 0.3 0.3 0.9 3.2 2.4 35.5 0.4 0.4 0.3 1.1 0.3 0.2 4.6 0.4 0.9 19.7 0.2 2.1 0.5 0.1 3.7 7.5 6.1 0.3 11.1 6.0 2.9 0.8 58.1 0.9 0.1 37.6 6.0 4.6 0.5 110.2 25.0 127.1 49.9 7.4 22.5 116.8 209.2 128.6 170.2 187.9 70.8 59.1 114.4 9.5 88.6 151.1 55.0 188.0 136.6 198.0 210.7 41.8 146.3 52.1 105.1 0.8 146.7 87.4 8.1 3.4 234.6 16.2 27.7 103.3 110.4 63.4 328.6 214.3 57.1 167.3 90.9 83.0 133.3 103.6 87.6 187.0 67.8 87.1 62.7 67.7 56.2 198.0 116.6 17.3 51.8 69.2 31.4 57.6 93.1 125.1 66.9 289.6 212.1 184.9 195.9 51.0 134.4 107.7 0.3 0.1 0.1 1.2 0.0 0.0 0.1 0.3 0.8 0.1 0.1 0.1 0.4 0.4 0.8 0.0 0.1 0.2 0.2 0.3 0.3 0.5 0.4 0.3 0.3 0.4 0.4 0.4 0.3 0.8 0.5 0.2 3.2 1.5 0.0 25.0 10.5 3.0 9.2 1.2 0.0 3.9 4.4 1.4 1.5 2.3 0.0 0.0 42.3 5.6 12.9 1.9 1.2 3.9 2.2 3.5 4.2 0.0 214.0 0.1 0.0 254.1 11.2 11.7 3.6 5.7 12.2 3.9 3.7 47.9 0.0 0.0 26.9 2.0 7.2 8.8 6.8 0.3 5.0 0.0 1.0 0.0 0.0 7.2 0.0 0.0 0.5 0.3 0.4 248.0 1.5 2.4 2.1 4.6 0.0 0.0 0.2 14.6 22.9 34.0 51.5 1.6 48.7 11.9 1.2 36.7 5.6 RRM2B p53R2 ENSG00000048392 "Ribonucleotide reductase regulatory TP53 inducible subunit M2B" Q7LG56 8 102204502-102238961 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "DNA damage, DNA repair, DNA replication" Oxidoreductase "Disease variant, FDA approved drug targets, Neuropathy, Primary mitochondrial disease, Progressive external ophthalmoplegia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB006854, HPA028812" Approved Enhanced Nucleoplasm,Cytosol NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" "Nucleoplasm, Cytosol" "CAB006854: , HPA028812: AB_10602246" "unprognostic (7.76e-3)" "unprognostic (4.14e-2)" "unprognostic (9.41e-3)" "unprognostic (3.41e-1)" "unprognostic (1.13e-2)" "unprognostic (1.28e-1)" "unprognostic (5.51e-2)" "unprognostic (1.35e-2)" "unprognostic (1.66e-1)" "unprognostic (9.40e-2)" "unprognostic (1.74e-2)" "unprognostic (1.03e-1)" "unprognostic (1.70e-2)" "unprognostic (4.32e-1)" "unprognostic (1.47e-1)" "unprognostic (2.52e-1)" "unprognostic (7.17e-2)" 11.5 21.2 10.5 11.5 12.1 7.1 12.1 13.6 11.5 12.5 26.5 15.3 15.0 11.6 15.1 11.2 13.5 11.9 16.7 10.1 13.7 24.4 22.6 22.0 20.1 13.6 12.4 12.0 13.5 45.0 10.3 13.8 13.9 15.7 15.5 21.9 10.9 13.8 30.4 11.0 10.1 11.7 14.1 14.3 9.5 9.7 12.6 10.1 39.9 34.9 19.6 11.2 5.4 16.8 15.3 26.5 30.7 18.3 43.7 41.3 24.6 34.8 41.4 18.1 21.0 9.6 11.9 97.5 31.8 38.7 18.5 5.7 15.1 35.2 25.3 15.8 16.2 24.4 10.3 20.9 35.3 7.6 50.0 53.1 66.1 20.2 30.5 43.0 51.8 16.3 18.2 14.6 59.1 15.2 13.1 14.6 17.7 16.5 19.2 8.2 12.7 20.1 43.1 17.1 7.8 15.4 17.9 9.7 21.1 76.3 25.5 17.1 39.4 27.8 53.7 19.6 9.6 15.3 15.3 88.0 41.0 11.5 30.2 15.7 6.3 7.0 2.7 5.4 3.8 6.6 2.3 3.2 7.7 8.6 2.6 2.8 23.1 4.1 11.5 2.2 1.8 3.3 10.5 12.1 13.6 11.5 10.1 13.7 13.6 12.4 13.9 14.1 12.6 16.8 16.2 57.7 29.3 10.1 33.5 19.4 8.2 11.8 34.1 13.5 17.0 9.4 22.8 20.0 23.9 40.5 14.6 13.8 13.9 7.3 25.4 6.8 2.3 36.2 11.1 14.9 29.4 3.8 14.6 8.2 5.9 14.8 6.1 11.8 11.4 11.2 18.5 23.6 12.6 10.1 17.6 9.7 10.2 26.2 39.5 1.4 14.3 23.8 17.8 20.6 18.2 24.5 7.2 16.1 12.1 5.7 5.7 14.7 9.3 10.7 8.1 22.7 39.9 18.3 6.6 16.2 16.8 13.2 14.5 26.2 18.5 4.8 12.2 8.6 12.1 6.7 SCD "FADS5, SCDOS" ENSG00000099194 "Stearoyl-CoA desaturase" O00767 10 100347233-100364826 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adipose tissue: 1233.7;brain: 839.9;liver: 583.8" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 389.6;Granulosa cells: 187.3;Hepatocytes: 840.3;Oligodendrocytes: 451.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "ASC diff: 2534.2;CAPAN-2: 1824.4" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA012107, HPA063921" Approved Enhanced "Endoplasmic reticulum" No Yes "Cluster 7: Monocytes - Unknown function" "Cluster 15: Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 15: Hepatocytes - Hemostasis" "Endoplasmic reticulum" "HPA012107: AB_1856610, HPA063921: AB_2685154" "unprognostic (2.10e-1)" "unprognostic (2.62e-3)" "unprognostic (7.86e-2)" "unprognostic (5.19e-2)" "unprognostic (1.24e-1)" "unprognostic (6.16e-2)" "unprognostic (1.13e-1)" "unprognostic (3.88e-2)" "unprognostic (6.53e-2)" "unprognostic (2.72e-1)" "unprognostic (1.47e-1)" "unprognostic (1.69e-1)" "prognostic unfavorable (7.56e-5)" "unprognostic (7.18e-2)" "unprognostic (3.27e-1)" "unprognostic (4.73e-2)" "prognostic unfavorable (7.79e-5)" 1233.7 131.2 408.7 25.7 525.8 23.0 261.5 535.7 522.1 43.2 156.6 42.9 93.1 15.4 25.5 107.8 5.0 28.7 47.1 349.1 457.5 18.5 583.8 142.8 17.2 775.0 508.9 49.6 22.6 79.5 10.3 19.9 637.8 100.1 39.7 17.9 112.6 11.2 6.1 27.0 36.0 15.9 574.4 15.3 25.2 51.8 538.7 18.4 13.0 7.2 21.0 22.5 41.9 839.9 411.2 373.3 777.6 536.4 2534.2 1449.4 158.2 43.4 948.3 101.6 536.6 323.8 1824.4 173.3 33.7 102.2 461.8 716.4 433.7 1549.5 88.9 59.4 179.6 97.5 219.3 653.4 488.4 136.9 100.9 795.5 459.4 395.0 688.9 273.1 196.2 375.3 275.4 513.3 41.7 646.8 155.9 163.3 270.7 120.7 106.3 72.6 287.4 550.4 443.8 455.3 48.9 185.3 85.8 399.7 834.9 224.2 447.7 291.3 79.0 10.0 115.9 9.1 89.8 141.4 81.5 262.9 184.4 416.0 65.9 0.0 0.8 0.0 1.4 1.6 2.3 0.6 0.5 0.7 2.7 0.9 0.4 1.3 0.1 1.4 0.0 1.5 0.0 1.2 408.7 525.8 535.7 522.1 349.1 457.5 775.0 508.9 637.8 574.4 538.7 839.9 3.8 54.5 389.6 34.0 15.7 3.7 4.5 121.8 0.6 6.5 16.1 6.2 11.2 28.6 66.2 0.0 6.2 3.0 4.7 21.5 0.0 14.6 52.6 13.9 9.0 12.5 25.8 15.8 4.8 67.9 71.7 15.9 25.0 26.9 6.3 187.3 32.9 840.3 34.1 26.9 5.2 16.4 52.9 113.5 4.2 93.0 3.7 21.2 58.7 8.4 10.2 11.9 2.1 18.6 451.5 29.6 2.7 1.5 3.7 31.4 16.2 4.9 31.0 6.2 0.0 3.6 25.7 2.0 1.2 26.7 2.3 17.4 6.6 97.8 38.9 8.2 SCD5 "ACOD4, FADS4, FLJ21032, HSCD5, SCD4" ENSG00000145284 "Stearoyl-CoA desaturase 5" Q86SK9 4 82629539-82798796 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Oxidoreductase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 156.7;brain: 353.6" "Cell type enhanced" "Detected in many" "Astrocytes: 248.4;Oligodendrocyte precursor cells: 892.7;Oligodendrocytes: 513.6" "Group enriched" "Detected in all" 6 "glioma: 152.4;thyroid cancer: 38.5" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "BJ: 69.2;RPTEC TERT1: 90.1" "Low region specificity" "Detected in all" HPA042380 Uncertain NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 70: Brain - Nervous system development" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 68: Oligodendrocytes - Mixed function" "HPA042380: AB_10794797" "unprognostic (3.23e-2)" "unprognostic (3.84e-2)" "unprognostic (2.86e-1)" "unprognostic (6.98e-2)" "unprognostic (1.58e-1)" "unprognostic (2.95e-1)" "unprognostic (2.83e-1)" "unprognostic (3.82e-2)" "unprognostic (6.82e-2)" "unprognostic (3.22e-1)" "unprognostic (1.04e-1)" "unprognostic (2.37e-2)" "prognostic favorable (2.32e-5)" "unprognostic (1.28e-1)" "unprognostic (1.26e-1)" "unprognostic (3.88e-3)" "unprognostic (2.92e-2)" 6.8 156.7 226.1 3.7 283.7 2.9 5.7 302.5 260.4 10.6 85.2 12.9 4.5 12.5 97.6 5.8 18.7 9.3 8.1 212.6 277.4 33.1 2.5 15.0 3.0 353.6 272.7 93.7 40.9 18.7 31.4 7.5 291.0 12.7 4.0 70.2 18.0 24.3 1.3 8.2 6.0 12.0 314.1 4.5 10.6 33.3 255.6 10.6 35.5 4.2 4.4 7.7 8.7 316.2 11.2 7.1 36.0 18.6 19.7 12.5 0.6 69.2 33.9 29.7 22.8 0.5 1.7 22.5 23.5 14.5 8.0 19.9 10.6 7.6 37.0 4.4 4.7 1.0 8.1 0.7 2.9 10.0 6.9 10.0 30.6 5.9 5.2 30.5 48.4 25.8 1.3 2.2 15.6 4.4 42.6 2.1 2.6 0.2 5.0 35.6 21.5 17.9 90.1 11.2 20.1 11.5 11.4 0.5 6.8 3.5 1.3 5.0 59.5 31.5 18.1 11.9 18.9 6.0 2.5 2.2 15.3 10.5 9.0 1.9 0.6 0.1 3.9 0.2 2.5 0.2 0.8 2.3 0.3 0.4 0.7 2.6 0.7 1.1 0.4 0.7 0.2 1.2 226.1 283.7 302.5 260.4 212.6 277.4 353.6 272.7 291.0 314.1 255.6 316.2 1.4 44.8 3.9 248.4 0.8 10.7 16.5 16.3 5.7 101.4 6.8 4.8 2.9 27.1 25.7 27.6 25.0 1.9 3.9 0.4 13.7 79.7 115.0 13.5 9.3 7.7 7.7 0.0 84.3 46.9 0.2 16.8 2.6 14.8 0.0 10.5 10.4 0.2 1.1 101.0 107.0 0.3 10.2 1.3 3.3 100.3 55.0 1.8 3.6 23.4 1.9 145.3 4.1 892.7 513.6 8.9 0.0 58.3 0.7 11.3 0.2 20.4 13.0 14.6 6.6 3.6 11.5 2.9 3.7 2.7 7.2 0.1 3.2 137.4 2.0 9.3 SOAT1 "ACAT, SOAT, STAT" ENSG00000057252 "Sterol O-acyltransferase 1" P35610 1 179293714-179358680 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted membrane proteins" "Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Acyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 4 "adrenal gland: 165.3" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009533, HPA047171" Enhanced Enhanced "Endoplasmic reticulum" NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 17: Adrenal gland - Steroid metabolism" "Cluster 28: BEWO - Transcription regulation" "Cluster 4: Macrophages - Innate immune response" "Endoplasmic reticulum" "CAB009533: AB_633499, HPA047171: AB_2679967" "unprognostic (3.29e-2)" "unprognostic (7.60e-2)" "unprognostic (1.11e-1)" "unprognostic (3.21e-2)" "unprognostic (2.83e-1)" "unprognostic (1.81e-3)" "unprognostic (7.81e-3)" "unprognostic (3.29e-1)" "unprognostic (9.00e-2)" "unprognostic (9.84e-2)" "unprognostic (1.06e-1)" "unprognostic (5.45e-3)" "unprognostic (7.02e-3)" "unprognostic (4.67e-3)" "unprognostic (9.64e-2)" "unprognostic (4.67e-2)" "unprognostic (1.82e-1)" 14.6 165.3 4.2 18.1 5.7 17.5 8.2 5.5 6.6 13.7 9.0 13.0 12.2 11.7 6.6 4.8 17.9 20.5 5.4 3.3 6.8 12.7 14.1 20.9 15.1 10.1 6.1 10.7 27.0 13.4 6.3 19.1 8.0 27.7 14.8 10.3 39.4 9.3 4.0 5.7 12.7 16.5 8.0 15.1 16.3 11.0 6.7 8.1 9.2 3.7 13.1 11.7 4.5 12.8 74.6 34.1 27.7 41.0 104.7 56.6 147.3 35.1 61.7 76.2 88.3 35.2 82.6 42.0 53.9 64.4 92.6 26.8 88.6 20.9 81.8 48.0 18.2 19.5 26.7 36.9 42.9 33.5 7.5 45.4 13.3 89.2 75.8 32.1 33.3 50.5 42.7 21.0 120.0 15.9 35.9 10.8 13.4 11.8 11.2 44.4 35.8 24.4 66.1 45.9 8.4 21.5 54.3 22.9 20.1 32.3 24.0 22.8 31.9 89.8 43.1 99.5 78.2 29.4 115.3 35.5 35.7 17.9 170.6 55.4 53.4 1.6 26.4 34.2 25.0 12.9 24.0 24.8 48.9 10.4 23.0 23.3 39.3 37.9 23.7 8.8 33.2 32.5 4.2 5.7 5.5 6.6 3.3 6.8 10.1 6.1 8.0 8.0 6.7 12.8 14.9 22.4 33.4 11.4 16.0 9.9 10.1 11.3 8.0 7.3 7.2 4.6 8.5 30.0 14.5 20.2 14.6 17.6 21.2 16.0 1.9 42.5 29.5 34.9 32.8 16.0 59.9 9.0 12.1 25.0 51.6 21.3 18.3 34.5 14.0 9.2 15.4 24.2 70.3 6.7 15.0 25.5 22.4 77.4 41.9 14.5 32.6 74.9 23.2 29.0 55.4 7.6 19.6 10.6 7.3 20.3 13.3 25.9 17.7 26.7 8.7 14.9 46.2 14.5 26.3 9.2 13.5 6.8 9.7 5.0 5.3 8.8 24.8 44.3 15.5 8.5 SOAT2 ACAT2 ENSG00000167780 "Sterol O-acyltransferase 2" O75908 12 53103486-53124535 "Enzymes, Metabolic proteins, Predicted membrane proteins, Transporters" "Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "intestine: 19.5" "Cell type enriched" "Detected in some" 5 "Proximal enterocytes: 14.3" "Group enriched" "Detected in some" 8 "liver cancer: 5.2;testis cancer: 5.5" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "MAIT T-cell: 1.1" "Lineage enriched" "Detected in single" 5 "T-cells: 1.1" "Group enriched" "Detected in some" 5 "CACO-2: 9.5;Hep G2: 22.6;U-266/70: 7.2" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 56: Intestine - Transmembrane transport" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 45: Enterocytes - Digestion" "unprognostic (2.53e-1)" "unprognostic (2.72e-3)" "unprognostic (1.15e-1)" "unprognostic (1.40e-1)" "unprognostic (1.30e-4)" "unprognostic (3.88e-3)" "unprognostic (9.26e-2)" "unprognostic (4.20e-2)" "unprognostic (1.32e-1)" "unprognostic (3.29e-1)" "unprognostic (1.06e-2)" "unprognostic (2.53e-1)" "unprognostic (1.83e-2)" "unprognostic (9.05e-2)" "unprognostic (2.37e-1)" "unprognostic (7.58e-3)" "unprognostic (3.28e-1)" 0.3 0.0 0.0 0.1 0.0 0.2 0.3 0.0 0.1 0.8 0.0 0.2 11.6 0.4 0.2 0.1 0.6 0.4 0.1 0.0 0.0 0.4 2.9 0.1 0.3 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.4 0.1 0.0 0.4 0.1 0.0 0.3 19.5 0.0 0.0 2.1 0.2 0.2 0.0 0.1 0.2 0.1 0.2 0.3 0.6 0.0 0.2 0.2 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.3 0.4 9.5 0.1 0.0 0.0 0.5 0.0 0.8 0.0 0.0 0.7 0.0 0.0 1.0 0.0 22.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.9 0.0 0.0 0.0 0.4 2.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 7.2 1.4 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.4 0.7 0.0 0.0 0.1 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.3 1.5 0.6 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.1 1.3 0.0 0.0 0.0 0.2 0.6 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.2 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.2 0.0 2.5 0.0 0.0 0.0 14.3 0.8 0.0 0.0 0.0 0.0 0.2 0.1 0.2 0.0 0.0 0.0 0.6 0.0 0.3 0.0 SULT1A1 "P-PST, STP, STP1" ENSG00000196502 "Sulfotransferase family 1A member 1" P50225 16 28603944-28623625 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Catecholamine metabolism, Lipid metabolism, Steroid metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 135.0;liver: 248.9" "Cell type enhanced" "Detected in many" "Distal enterocytes: 321.6;Hepatocytes: 229.6;Kupffer cells: 214.1;Paneth cells: 309.3;Proximal enterocytes: 926.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 6 "classical monocyte: 257.6;intermediate monocyte: 212.2;myeloid DC: 116.3;neutrophil: 246.7;non-classical monocyte: 122.6" "Group enriched" "Detected in all" 33 "dendritic cells: 116.3;granulocytes: 246.7;monocytes: 257.6" "Group enriched" "Detected in many" 4 "EFO-21: 171.0;Hep G2: 353.6" "HPA049500, HPA051051" Supported NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 45: Enterocytes - Digestion" "HPA049500: AB_2680796, HPA051051: AB_2681327" "unprognostic (2.57e-2)" "unprognostic (2.80e-2)" "unprognostic (8.40e-2)" "unprognostic (1.30e-1)" "unprognostic (5.60e-3)" "unprognostic (7.63e-2)" "unprognostic (4.17e-2)" "prognostic favorable (7.02e-4)" "unprognostic (1.30e-1)" "unprognostic (2.40e-1)" "unprognostic (6.71e-2)" "unprognostic (2.07e-1)" "unprognostic (3.70e-3)" "unprognostic (1.49e-1)" "unprognostic (4.10e-2)" "unprognostic (7.39e-2)" "unprognostic (1.89e-2)" 30.5 100.1 21.0 10.6 21.5 23.7 15.3 21.2 23.5 8.8 31.0 54.0 135.0 7.2 32.3 5.1 14.2 10.9 26.5 22.5 22.7 30.8 248.9 46.6 15.2 22.8 21.7 7.3 17.8 23.4 24.2 12.4 21.8 8.9 41.7 6.0 26.2 20.3 11.3 3.0 104.3 11.1 21.4 66.2 22.2 13.8 22.2 7.6 35.3 4.8 4.2 13.6 5.1 21.7 6.6 1.5 2.7 10.9 0.0 0.0 23.2 0.0 0.2 0.1 0.0 0.9 42.2 0.3 171.0 0.2 1.6 0.4 3.1 12.1 0.3 0.7 30.8 7.2 13.1 353.6 18.3 0.0 12.6 1.1 0.9 0.0 0.0 0.2 2.9 11.9 4.4 4.2 3.0 39.9 0.7 11.0 2.5 1.8 0.1 11.6 1.3 20.5 2.9 2.9 6.9 0.4 0.4 55.7 1.1 14.1 32.8 32.2 22.5 0.5 7.8 0.4 0.0 5.8 5.5 1.6 2.7 63.1 0.0 32.4 257.6 5.0 1.4 212.2 1.2 1.2 1.9 1.4 116.3 0.3 2.9 1.4 246.7 4.3 122.6 8.6 6.3 129.1 21.0 21.5 21.2 23.5 22.5 22.7 22.8 21.7 21.8 21.4 22.2 21.7 7.1 192.3 97.0 25.1 4.6 1.1 8.0 13.2 9.6 21.8 14.4 9.9 14.2 80.1 17.8 16.5 10.4 2.4 3.0 321.6 129.1 13.4 107.8 18.2 5.9 17.0 19.9 20.2 34.4 19.9 1.4 29.2 23.0 5.2 49.9 15.9 43.9 229.6 38.5 8.4 27.5 63.9 14.2 214.1 8.9 34.4 51.3 45.3 1.8 5.6 37.8 67.8 3.1 18.1 3.6 6.2 309.3 34.6 3.6 3.9 926.9 80.9 40.2 3.8 19.7 11.2 15.2 22.8 5.8 9.6 0.3 1.9 9.0 13.1 79.2 6.8 TPO TPX ENSG00000115705 "Thyroid peroxidase" P07202 2 1374066-1543711 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrogen peroxide, Thyroid hormones biosynthesis" "Oxidoreductase, Peroxidase" "Congenital hypothyroidism, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 70 "thyroid gland: 1588.2" "Cell type enhanced" "Detected in some" "Adipocytes: 24.5;Early spermatids: 4.2;Endothelial cells: 12.6;Late spermatids: 7.5;Peritubular cells: 3.8" "Cancer enriched" "Detected in some" 364 "thyroid cancer: 188.3" "Not detected" "Not detected" "Group enriched" "Detected in some" 12 "memory CD4 T-cell: 2.0;T-reg: 1.2" "Lineage enriched" "Detected in single" 20 "T-cells: 2.0" "Group enriched" "Detected in some" 5 "Karpas-707: 9.9;RPMI-8226: 3.9" "Not detected" "Not detected" "Not detected" "Not detected" "HPA007987, CAB009587" Enhanced "Intracellular and membrane" NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 1: Thyroid gland - Transcription" "Cluster 2: Karpas-707 - Immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "CAB009587: , HPA007987: AB_1080270" "unprognostic (1.55e-1)" "unprognostic (1.04e-1)" "unprognostic (2.88e-1)" "unprognostic (1.77e-2)" "unprognostic (3.56e-2)" "unprognostic (9.11e-2)" "unprognostic (2.24e-2)" "unprognostic (1.85e-1)" "unprognostic (1.32e-1)" "unprognostic (1.19e-4)" "unprognostic (2.61e-2)" "unprognostic (3.29e-1)" "unprognostic (5.44e-4)" "unprognostic (1.21e-1)" "unprognostic (3.73e-2)" "unprognostic (4.98e-3)" "unprognostic (7.10e-3)" 13.1 0.3 0.1 0.4 0.0 0.1 11.0 0.0 0.6 0.1 0.0 4.6 0.6 0.6 0.0 2.0 0.7 3.0 11.5 0.1 0.2 0.2 0.6 0.8 1.4 0.2 0.1 0.3 2.3 0.3 0.6 0.0 0.1 0.6 0.9 0.2 3.4 0.0 6.0 1.8 3.8 0.6 0.1 22.8 2.8 1.2 0.2 0.0 1588.2 5.6 0.4 2.1 1.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 9.9 0.0 1.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 3.9 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.8 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.2 0.2 0.1 0.0 0.0 0.6 0.1 0.2 0.2 0.1 0.1 0.1 0.2 0.4 24.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 4.2 0.0 0.2 12.6 0.0 0.0 2.4 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 7.5 0.6 0.4 0.0 0.0 0.0 0.0 0.0 1.0 0.3 0.0 1.1 3.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.4 0.8 0.3 0.5 0.1 0.0 0.0 0.2 0.1 0.0 0.1 TPP1 "CLN2, LPIC, SCAR7, TPP-1" ENSG00000166340 "Tripeptidyl peptidase 1" O14773 11 6612768-6619448 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Disease variant, Epilepsy, Neurodegeneration, Neuronal ceroid lipofuscinosis, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hofbauer cells: 261.6;Kupffer cells: 376.5;Macrophages: 219.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037709, HPA044868" Enhanced "Intracellular and membrane" NA NA 9500000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 3: HMC-1 - Innate immune response" "Cluster 4: Macrophages - Innate immune response" "HPA037709: AB_10672913, HPA044868: AB_2679122" "unprognostic (8.27e-3)" "unprognostic (5.85e-2)" "unprognostic (7.12e-3)" "unprognostic (3.34e-3)" "unprognostic (1.56e-2)" "prognostic unfavorable (4.31e-4)" "prognostic unfavorable (1.11e-4)" "unprognostic (6.32e-2)" "unprognostic (3.01e-1)" "unprognostic (2.39e-2)" "unprognostic (1.31e-1)" "unprognostic (6.54e-2)" "unprognostic (6.23e-2)" "prognostic unfavorable (4.46e-4)" "unprognostic (3.87e-2)" "unprognostic (2.59e-1)" "unprognostic (1.12e-2)" 74.7 145.9 71.0 74.6 81.0 111.7 44.3 80.3 81.4 53.8 120.1 59.1 59.9 74.0 43.1 39.5 47.1 65.1 56.3 70.6 78.4 71.6 92.7 81.5 77.7 85.2 82.6 49.7 36.2 54.2 63.6 94.2 81.0 38.9 59.7 48.5 42.5 57.5 31.4 39.5 73.3 92.0 74.7 135.0 48.4 20.0 83.3 47.4 45.7 39.0 60.9 68.4 42.8 90.4 26.1 48.1 25.9 50.5 309.9 160.1 21.8 50.9 220.7 36.9 62.0 20.1 122.5 37.4 32.6 136.6 220.2 85.8 48.3 68.7 57.9 37.3 27.6 32.2 23.8 54.9 210.9 45.8 182.6 231.8 104.5 45.9 102.6 240.4 158.8 32.9 59.8 124.6 110.4 30.2 16.6 52.4 18.0 61.5 57.1 36.1 21.6 77.0 62.8 38.2 4.5 20.4 52.6 44.6 91.0 76.5 30.8 79.7 188.0 119.7 33.1 101.1 19.8 92.3 95.3 14.0 139.8 101.7 64.5 67.0 167.1 38.2 39.9 171.2 30.0 35.1 31.4 41.0 185.9 37.0 20.1 27.2 27.5 29.1 125.1 93.1 60.3 138.8 71.0 81.0 80.3 81.4 70.6 78.4 85.2 82.6 81.0 74.7 83.3 90.4 32.0 25.6 37.3 31.6 53.0 23.7 28.4 29.8 13.1 24.8 21.1 23.9 41.8 50.1 26.8 16.5 12.5 35.4 71.0 55.2 5.9 42.2 11.8 13.3 30.2 40.7 16.7 37.5 12.5 13.4 45.3 40.3 16.3 24.8 62.2 25.6 75.7 81.0 261.6 15.2 12.4 31.3 26.4 376.5 126.5 11.2 27.1 219.8 90.7 15.9 156.0 37.9 49.4 8.0 21.9 17.4 44.1 26.4 26.4 23.5 99.7 51.6 14.5 23.8 6.6 19.0 20.3 0.8 1.1 27.6 20.0 88.0 42.2 24.6 32.5 26.5 TXN TRX ENSG00000136810 Thioredoxin P10599 9 110243810-110256507 "Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Electron transport, Transcription, Transcription regulation, Transport" Activator Allergen "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "esophagus: 1058.8" "Cell type enriched" "Detected in all" 4 "monocytes: 15775.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 4 "dendritic cells: 1642.2;granulocytes: 1355.4" "Cell line enhanced" "Detected in all" "OE19: 3836.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008678, HPA047478, HPA055752" Enhanced Enhanced Nucleoplasm,Cytosol "Intracellular and membrane" NA NA 16000000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 37: Intestine - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 3: Monocytes - Immune response regulation" "Nucleoplasm, Cytosol" "CAB008678: AB_1623676, HPA047478: AB_2680063, HPA055752: AB_2682907" "unprognostic (2.12e-2)" "unprognostic (1.27e-1)" "unprognostic (9.77e-2)" "prognostic favorable (3.40e-6)" "unprognostic (1.80e-2)" "unprognostic (2.13e-2)" "unprognostic (5.52e-3)" "unprognostic (1.37e-2)" "unprognostic (1.75e-1)" "unprognostic (3.36e-2)" "unprognostic (5.93e-3)" "unprognostic (1.66e-1)" "unprognostic (4.96e-3)" "unprognostic (7.80e-2)" "unprognostic (8.55e-2)" "unprognostic (2.99e-2)" "unprognostic (8.51e-2)" 144.2 127.7 149.9 145.4 155.3 367.5 218.6 154.5 225.4 153.9 140.5 455.2 349.3 130.9 168.4 1058.8 240.7 142.1 90.8 156.2 161.7 430.6 436.0 158.4 131.6 163.3 156.2 83.8 119.1 73.0 61.2 105.8 163.0 113.6 435.0 46.2 391.7 128.9 84.8 240.1 332.2 140.3 158.1 105.4 222.7 36.6 156.4 261.3 93.8 76.4 208.3 218.1 230.8 164.8 672.9 920.0 238.7 265.6 601.0 782.3 352.7 792.5 756.2 555.6 419.4 606.8 785.6 598.9 331.5 754.7 1181.3 1464.8 351.0 1081.1 544.6 887.6 778.5 298.2 804.7 1061.8 684.7 747.2 864.2 556.2 703.5 809.0 607.8 504.7 498.7 369.7 515.9 553.1 775.4 557.1 621.9 1119.7 505.4 3836.3 1110.5 256.6 810.3 696.3 721.7 479.4 520.9 183.7 860.0 687.5 572.7 458.6 661.2 508.6 587.9 556.4 357.3 1050.2 1006.1 271.4 872.5 512.7 804.8 654.4 789.5 484.8 311.2 1355.4 169.2 195.5 165.2 154.2 237.7 207.3 475.7 75.9 87.4 129.3 1212.7 195.0 131.6 1642.2 337.0 279.2 149.9 155.3 154.5 225.4 156.2 161.7 163.3 156.2 163.0 158.1 156.4 164.8 458.7 391.0 298.2 12.4 165.9 1304.5 1072.4 3654.4 435.4 38.0 514.2 752.8 108.5 418.9 1810.0 263.0 20.9 637.2 443.0 1297.7 972.4 1172.8 31.2 1560.7 1465.0 587.0 556.4 388.4 18.2 1341.7 993.1 526.8 662.1 775.9 268.6 247.1 216.0 842.8 571.8 28.6 18.3 1111.2 2191.1 286.1 1752.9 31.6 403.2 682.7 763.1 10.3 15775.8 86.3 128.8 7.5 21.9 1994.7 1227.7 285.5 388.5 2151.2 1439.2 3670.6 1516.8 34.8 144.7 211.8 557.8 10.6 76.3 2725.7 1491.0 468.2 266.6 879.4 1621.8 1742.1 TXN2 MT-TRX ENSG00000100348 "Thioredoxin 2" Q99757 22 36467046-36481640 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Electron transport, Transport" "Neurodegeneration, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000994, CAB008681" Approved Enhanced Mitochondria No No 84000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "CAB008681: AB_1623682, HPA000994: AB_1080267" "unprognostic (5.11e-2)" "unprognostic (4.40e-3)" "unprognostic (4.40e-3)" "unprognostic (1.07e-2)" "unprognostic (5.85e-2)" "unprognostic (4.28e-2)" "unprognostic (4.02e-2)" "unprognostic (5.05e-2)" "unprognostic (2.15e-1)" "unprognostic (1.78e-1)" "unprognostic (3.17e-2)" "prognostic favorable (2.04e-4)" "prognostic favorable (1.17e-6)" "unprognostic (1.49e-2)" "unprognostic (2.78e-1)" "unprognostic (1.06e-1)" "unprognostic (2.05e-1)" 60.3 182.3 89.8 45.5 92.4 64.7 58.0 94.6 98.2 57.4 92.4 65.3 84.0 50.0 51.7 79.8 64.1 49.4 122.3 87.9 90.7 91.5 149.5 44.7 59.2 92.9 91.3 75.8 59.2 99.1 43.4 47.3 91.9 59.3 63.6 43.0 59.5 52.5 159.4 60.5 64.3 48.3 91.2 65.7 76.1 48.8 97.0 50.9 67.7 180.1 59.9 59.0 54.0 91.7 52.8 80.4 75.4 126.8 115.2 125.0 81.3 70.8 108.1 114.8 128.7 87.9 52.1 133.3 64.2 116.8 54.5 76.1 151.7 127.4 66.1 93.6 131.8 147.7 91.7 125.4 94.6 189.6 125.8 162.3 98.9 101.9 79.3 99.5 118.2 78.4 157.7 104.1 106.1 80.3 87.5 128.2 60.0 170.3 95.3 75.3 79.5 92.6 116.4 84.8 99.9 98.3 70.2 148.1 125.3 61.3 103.6 165.9 83.7 120.5 95.0 69.8 65.9 81.4 64.2 128.6 111.0 109.5 74.1 30.2 173.5 32.3 102.5 194.3 108.9 140.4 101.2 109.0 223.4 133.8 116.4 108.6 59.3 145.4 170.1 167.1 110.9 224.3 89.8 92.4 94.6 98.2 87.9 90.7 92.9 91.3 91.9 91.2 97.0 91.7 68.9 60.9 53.0 12.1 66.4 83.5 87.7 154.0 108.1 105.6 124.3 137.7 105.4 88.6 82.5 69.9 39.6 213.2 62.8 128.5 303.3 93.0 19.6 45.7 70.6 73.7 89.5 114.0 8.3 106.2 275.8 74.0 75.4 57.2 69.1 148.0 81.0 122.7 173.4 116.1 10.3 132.4 95.6 100.5 80.7 36.8 56.5 80.7 78.2 8.4 91.9 168.9 77.2 9.0 13.5 82.5 104.3 50.8 79.5 52.7 252.2 213.7 49.0 59.4 19.7 61.1 67.1 49.1 42.4 124.5 89.8 207.1 62.4 287.0 179.6 87.1 TXNRD1 "GRIM-12, Trxr1, TXNR" ENSG00000198431 "Thioredoxin reductase 1" Q16881 12 104215779-104350307 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Electron transport, Transport" Oxidoreductase "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 459.7;Prostatic glandular cells: 557.4;Urothelial cells: 488.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "fHDF/TERT166: 1452.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001395, CAB004607, CAB015834, HPA043871" Approved Supported Nucleoplasm NA NA 6100000 "Cluster 46: Basophils - DNA binding" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 22: Epithelial cell types - Mixed function" Nucleoplasm "CAB004607: AB_628405, CAB015834: , HPA001395: AB_1858377, HPA043871: AB_2678709" "unprognostic (2.52e-2)" "unprognostic (1.16e-1)" "unprognostic (5.48e-2)" "unprognostic (1.01e-1)" "unprognostic (3.15e-1)" "unprognostic (1.94e-2)" "prognostic unfavorable (1.12e-5)" "unprognostic (5.55e-2)" "unprognostic (1.18e-1)" "unprognostic (1.08e-1)" "unprognostic (6.42e-2)" "unprognostic (2.21e-1)" "prognostic unfavorable (1.20e-5)" "unprognostic (2.13e-1)" "unprognostic (1.27e-1)" "unprognostic (1.18e-2)" "unprognostic (8.80e-2)" 47.1 148.1 22.5 40.6 21.1 64.7 28.0 20.9 22.6 28.0 37.3 50.9 58.4 47.9 21.0 30.7 39.0 55.9 65.8 21.1 29.8 37.9 46.5 63.0 34.4 55.2 26.7 34.1 19.0 33.8 21.2 39.1 33.3 41.0 45.6 20.1 20.8 60.6 67.8 12.4 39.4 51.6 22.9 27.8 52.1 37.8 24.6 42.8 30.4 64.0 34.1 141.6 30.1 25.7 228.4 1032.6 118.1 111.3 553.5 308.0 409.8 412.4 259.3 182.7 186.8 110.5 329.4 169.3 187.0 1452.6 682.1 77.7 235.7 158.6 214.1 82.7 101.8 143.1 765.8 468.0 885.7 226.3 149.9 176.9 159.8 403.7 128.1 557.1 634.0 227.9 200.5 77.5 276.8 109.1 233.4 102.7 114.4 453.0 1053.1 227.3 82.1 146.5 211.2 123.1 182.6 110.6 333.3 519.1 325.2 222.6 123.2 131.4 854.5 89.3 183.7 201.3 341.2 84.8 179.9 254.5 186.8 122.5 538.0 109.4 29.9 69.7 23.6 39.0 26.9 21.3 21.6 23.9 39.5 14.5 19.1 16.7 102.6 24.4 48.4 25.2 19.8 27.6 22.5 21.1 20.9 22.6 21.1 29.8 55.2 26.7 33.3 22.9 24.6 25.7 26.0 64.1 67.5 50.3 27.6 104.0 459.7 41.3 40.9 28.1 19.4 16.3 66.2 32.9 79.3 16.5 22.9 26.1 40.4 93.4 41.1 79.6 45.0 100.9 36.8 116.2 20.4 46.3 48.2 80.7 34.3 90.1 69.8 119.6 53.2 35.2 49.2 68.2 42.0 28.6 56.7 18.8 44.7 43.5 100.5 19.1 68.0 62.2 19.6 49.6 51.9 24.8 26.8 29.1 55.3 197.7 40.5 29.3 28.4 557.4 24.6 37.5 105.5 20.9 0.0 43.4 84.0 14.4 33.8 24.3 72.9 51.3 28.5 98.4 33.0 488.0 TXNRD2 "SELZ, TR, TR3, TRXR2" ENSG00000184470 "Thioredoxin reductase 2" Q9NNW7 22 19875517-19941820 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-2 OS: 139.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002007, HPA003323" Supported Approved Mitochondria,Cytosol NA NA 2800000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 18: Non-specific - Mitochondria" "Cluster 1: K-562 - Erythropoiesis" "Cluster 47: Cytotrophoblasts - Unknown function" "Mitochondria, Cytosol" "CAB002007: , HPA003323: AB_1080396" "unprognostic (3.17e-2)" "unprognostic (8.72e-2)" "unprognostic (4.30e-1)" "unprognostic (9.71e-3)" "unprognostic (7.25e-2)" "unprognostic (6.35e-2)" "unprognostic (3.21e-1)" "unprognostic (1.12e-1)" "unprognostic (2.78e-1)" "unprognostic (2.83e-1)" "unprognostic (4.94e-3)" "unprognostic (2.49e-1)" "prognostic favorable (1.10e-7)" "unprognostic (2.47e-1)" "unprognostic (5.99e-2)" "unprognostic (1.69e-1)" "unprognostic (1.10e-1)" 10.5 44.4 11.9 8.9 12.0 14.5 12.3 18.1 19.3 11.7 21.2 14.9 10.3 10.6 6.2 10.2 10.6 6.2 30.0 12.9 11.9 24.8 65.4 13.6 9.1 11.8 12.1 16.5 15.9 13.5 14.4 9.8 11.5 26.8 4.6 4.4 15.4 8.2 23.0 10.9 12.0 5.1 11.3 16.9 26.4 14.6 12.4 4.9 15.2 16.1 6.1 11.8 10.4 11.8 19.4 39.2 3.5 14.9 6.9 9.6 8.8 18.8 21.1 31.8 23.4 36.7 19.4 10.9 43.2 19.0 32.7 33.2 17.8 25.2 12.1 21.6 46.5 18.8 34.4 22.4 12.9 21.1 8.4 9.2 18.5 16.2 13.8 12.9 91.3 2.2 106.4 17.4 24.8 47.1 7.2 30.1 17.7 46.9 27.6 10.5 85.2 10.0 19.3 21.0 19.1 16.4 32.0 39.9 21.8 5.8 33.7 27.6 52.2 23.0 139.5 19.8 38.4 17.6 14.0 6.9 22.4 15.5 30.3 2.7 10.5 5.8 3.5 8.2 2.6 3.9 3.0 3.2 7.8 2.6 3.9 3.2 0.9 3.8 7.9 2.9 2.1 4.6 11.9 12.0 18.1 19.3 12.9 11.9 11.8 12.1 11.5 11.3 12.4 11.8 5.6 16.0 23.6 11.1 10.3 4.2 23.1 15.1 3.4 22.1 11.4 9.1 16.7 15.7 15.7 20.2 10.4 60.7 8.8 14.7 58.7 22.0 26.4 9.8 8.4 14.4 1.2 33.1 9.2 32.0 24.3 12.4 23.4 10.0 1.3 27.6 8.9 49.5 25.9 10.1 8.5 16.9 20.3 22.0 7.8 18.2 15.5 14.6 5.4 10.3 27.2 18.7 10.3 8.5 7.2 22.3 13.9 9.1 12.2 17.8 15.6 52.0 16.6 11.0 6.6 11.3 13.3 10.9 14.0 6.4 5.3 42.0 11.4 36.4 16.4 15.7 UGT1A1 "GNT1, UGT1, UGT1A" ENSG00000241635 "UDP glucuronosyltransferase family 1 member A1" P22309 2 233760270-233773300 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 26 "intestine: 201.2;liver: 322.4" "Cell type enriched" "Detected in some" 7 "Hepatocytes: 105.0" "Cancer enriched" "Detected in some" 19 "liver cancer: 16.4" "Low region specificity" "Detected in single" "Immune cell enhanced" "Detected in single" "neutrophil: 1.4" "Lineage enriched" "Detected in single" 4 "granulocytes: 1.4" "Cell line enhanced" "Detected in some" "HaCaT: 14.0;OE19: 64.5;RT4: 34.7" "Not detected" "Not detected" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 2: Hepatocytes - Metabolism" "unprognostic (7.28e-2)" "unprognostic (2.49e-2)" "unprognostic (3.60e-1)" "unprognostic (5.69e-2)" "unprognostic (4.17e-3)" "unprognostic (6.31e-3)" "unprognostic (1.94e-5)" "unprognostic (2.78e-3)" "unprognostic (2.99e-4)" 0.1 0.1 0.6 0.2 0.5 0.5 0.2 1.5 0.8 0.1 0.2 3.0 201.2 0.2 0.4 3.5 0.1 1.0 0.2 0.4 0.8 4.0 322.4 0.2 0.3 0.2 0.2 0.2 0.1 0.1 0.0 0.1 0.2 0.2 2.4 0.9 0.5 0.3 0.1 1.8 79.2 0.1 0.0 0.2 2.4 0.6 0.3 0.1 0.2 0.1 0.3 10.0 0.9 0.6 0.3 1.1 0.2 0.2 0.1 0.1 0.6 0.0 0.0 0.0 0.1 5.4 0.3 0.2 2.5 0.1 0.1 14.0 0.0 0.2 0.0 0.2 0.1 0.1 0.6 1.6 0.0 0.5 0.2 0.2 0.6 0.0 0.0 0.1 0.0 0.3 0.2 0.6 0.0 0.8 0.1 0.3 0.5 64.5 6.5 0.1 0.1 0.6 0.0 34.7 0.2 0.4 2.6 0.4 0.0 0.2 0.2 0.0 0.1 0.2 0.1 0.3 0.0 0.2 0.2 0.1 0.7 0.4 0.2 0.9 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.2 0.1 0.1 1.4 0.3 0.1 0.1 0.1 0.0 0.6 0.5 1.5 0.8 0.4 0.8 0.2 0.2 0.2 0.0 0.3 0.6 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.1 0.6 0.0 0.0 0.0 0.0 0.0 3.7 1.8 0.0 0.0 0.0 1.8 0.0 0.1 2.9 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 1.1 105.0 0.0 0.0 0.0 0.4 0.0 2.4 0.0 1.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 1.6 0.0 0.1 6.9 14.6 2.2 1.5 0.0 0.0 0.4 0.1 0.2 0.1 1.5 0.0 0.0 0.1 0.0 0.7 7.3 UGT1A10 UGT1J ENSG00000242515 "UDP glucuronosyltransferase family 1 member A10" Q9HAW8 2 233636454-233773305 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "gallbladder: 22.0;intestine: 79.5;stomach 1: 32.7" "Cell type enhanced" "Detected in some" "Distal enterocytes: 1.8;Gastric mucus-secreting cells: 3.6;Intestinal goblet cells: 1.0;Paneth cells: 1.4;Proximal enterocytes: 3.9;Squamous epithelial cells: 4.3" "Cancer enhanced" "Detected in many" "urothelial cancer: 9.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 143 "RT4: 523.3" "Intracellular and membrane" NA NA "Cluster 9: Intestine - Unknown function" "Cluster 15: RT4 - Unknown function" "Cluster 45: Enterocytes - Digestion" "unprognostic (9.33e-2)" "unprognostic (7.64e-2)" "unprognostic (2.45e-3)" "unprognostic (1.73e-1)" "prognostic unfavorable (4.55e-4)" "unprognostic (1.49e-10)" "unprognostic (2.90e-1)" "unprognostic (1.50e-1)" "unprognostic (3.59e-3)" 0.1 0.0 0.0 3.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 49.5 79.5 0.1 0.0 14.6 0.0 22.0 0.0 0.0 0.0 0.4 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 36.5 0.0 0.9 0.0 0.0 0.9 53.1 1.9 0.0 0.0 32.7 1.5 0.0 0.0 0.0 0.0 0.3 1.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.3 1.4 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 523.3 0.0 0.1 3.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.6 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.0 0.3 0.3 UGT1A4 "HUG-BR2, UGT1D" ENSG00000244474 "UDP glucuronosyltransferase family 1 member A4" P22310 2 233718736-233773300 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 68 "liver: 391.7" "Cell type enriched" "Detected in some" 6 "Hepatocytes: 15.1" "Cancer enriched" "Detected in single" 487 "liver cancer: 24.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 2: Hepatocytes - Metabolism" "unprognostic (9.89e-3)" "unprognostic (6.77e-5)" "unprognostic (2.59e-1)" "unprognostic (3.50e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.7 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 391.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT1A6 "GNT1, HLUGP, UGT1F" ENSG00000167165 "UDP glucuronosyltransferase family 1 member A6" P19224 2 233691607-233773300 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "kidney: 71.3;liver: 143.3;urinary bladder: 88.8" "Cell type enhanced" "Detected in some" "Basal squamous epithelial cells: 12.5;Early spermatids: 52.4;Gastric mucus-secreting cells: 14.3;Late spermatids: 23.3;Squamous epithelial cells: 17.3" "Group enriched" "Detected in many" 5 "liver cancer: 7.2;lung cancer: 3.1;renal cancer: 7.6;urothelial cancer: 3.2" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "OE19: 1194.0" "Not detected" "Not detected" "CAB009819, HPA054065, HPA056023" Enhanced Supported "Endoplasmic reticulum,Vesicles" NA NA "Cluster 85: Liver - Metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 34: Spermatids - Unknown function" Vesicles "Endoplasmic reticulum" "CAB009819: AB_2241481, HPA054065: AB_2682367, HPA056023: " "unprognostic (9.09e-2)" "unprognostic (6.07e-2)" "unprognostic (5.43e-2)" "unprognostic (6.03e-2)" "prognostic unfavorable (2.89e-6)" "unprognostic (2.79e-1)" "unprognostic (6.18e-2)" "unprognostic (2.09e-3)" "unprognostic (9.97e-2)" "unprognostic (2.16e-2)" "unprognostic (3.52e-1)" "unprognostic (7.50e-2)" "unprognostic (2.01e-2)" 0.1 0.0 0.0 0.1 0.0 0.0 0.8 0.0 0.0 1.8 0.0 1.8 5.8 0.1 2.6 16.1 0.0 3.5 0.0 0.0 0.0 71.3 143.3 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 1.1 1.3 0.0 2.6 3.6 0.0 11.1 2.6 0.0 0.0 0.0 17.4 0.4 0.0 1.2 0.5 0.0 5.8 88.8 5.5 0.0 4.2 1.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 53.8 1.6 0.0 80.2 0.1 0.8 294.5 0.1 4.0 0.0 0.0 0.0 0.0 0.3 1.3 0.0 0.0 0.3 0.0 31.2 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 6.2 0.0 0.0 0.0 1194.0 0.0 0.1 0.2 0.1 3.2 149.0 0.0 0.0 7.1 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 1.6 1.2 12.5 0.0 0.0 0.0 0.3 0.0 2.9 1.8 0.0 0.0 0.0 0.4 0.0 0.0 52.4 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 14.3 0.5 0.0 0.0 0.4 5.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 23.3 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.9 0.5 1.8 0.1 0.0 0.0 0.0 0.0 1.2 0.2 17.3 1.1 0.0 0.0 0.0 0.1 3.0 UGT1A7 UGT1G ENSG00000244122 "UDP glucuronosyltransferase family 1 member A7" Q9HAW7 2 233681938-233773299 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 12 "esophagus: 83.8" "Cell type enriched" "Detected in some" 4 "Squamous epithelial cells: 40.7" "Group enriched" "Detected in some" 10 "cervical cancer: 1.2;head and neck cancer: 2.3;lung cancer: 3.0" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 15 "SiHa: 112.2" NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 20: HeLa - Mitochondria" "Cluster 61: Squamous epithelial cells - Keratinization" "unprognostic (6.27e-2)" "unprognostic (1.02e-1)" "unprognostic (7.76e-2)" "unprognostic (1.03e-2)" "unprognostic (1.09e-1)" "unprognostic (7.92e-2)" "unprognostic (1.71e-7)" "unprognostic (2.14e-1)" "unprognostic (4.57e-2)" 0.1 1.3 0.2 0.0 0.2 0.0 0.4 0.5 0.8 1.2 0.4 0.3 0.2 0.0 0.0 83.8 0.0 0.0 0.0 0.3 0.2 0.7 4.3 0.0 0.0 0.2 0.5 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.1 5.6 0.0 0.0 3.6 0.1 0.0 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.0 5.2 0.4 7.1 1.0 0.0 1.8 0.1 0.0 0.8 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 112.2 7.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.5 0.8 0.3 0.2 0.2 0.5 0.2 0.1 0.3 1.0 0.0 0.0 0.0 0.0 0.0 0.4 2.3 1.3 4.6 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 2.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 2.8 0.7 0.3 0.2 0.0 0.0 0.0 0.2 0.0 0.0 40.7 1.7 0.0 0.0 0.0 0.5 8.5 UGT1A9 "HLUGP4, LUGP4, UGT1AI" ENSG00000241119 "UDP glucuronosyltransferase family 1 member A9" O60656 2 233671898-233773300 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 370 "kidney: 458.6;liver: 195.6" "Group enriched" "Detected in some" 11 "Hepatocytes: 7.5;Proximal tubular cells: 6.6" "Group enriched" "Detected in some" 157 "liver cancer: 16.1;renal cancer: 16.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 13 "A549: 1.4;RT4: 1.2" NA NA "Cluster 81: Kidney & Liver - Metabolism" "Cluster 15: RT4 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "unprognostic (2.46e-2)" "unprognostic (3.56e-1)" "prognostic unfavorable (5.04e-5)" "unprognostic (4.26e-2)" "unprognostic (1.60e-1)" 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 458.6 195.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 6.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT2B10 ENSG00000109181 "UDP glucuronosyltransferase family 2 member B10" P36537 4 68815994-68832023 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 149 "liver: 233.7" "Cell type enriched" "Detected in some" 11 "Hepatocytes: 245.3" "Cancer enriched" "Detected in single" 296 "liver cancer: 93.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 116 "Hep G2: 12.0" HPA045108 Uncertain NA NA "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" "HPA045108: AB_2679218" "unprognostic (3.50e-3)" "unprognostic (1.92e-3)" "unprognostic (4.17e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 233.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.6 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 21.0 0.1 0.0 0.3 0.0 10.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 245.3 0.0 0.0 0.0 0.3 0.0 7.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.4 0.0 0.2 0.0 UGT2B11 ENSG00000213759 "UDP glucuronosyltransferase family 2 member B11" O75310 4 69199951-69214748 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 21 "breast: 239.4" "Group enriched" "Detected in some" 4 "Breast glandular cells: 13.7;Cholangiocytes: 7.2" "Group enriched" "Detected in some" 17 "breast cancer: 17.4;liver cancer: 13.1" "Not detected" "Not detected" "Group enriched" "Detected in some" 42 "basophil: 4.7;eosinophil: 3.5" "Lineage enriched" "Detected in single" 47 "granulocytes: 4.7" "Not detected" "Not detected" HPA045108 Uncertain NA NA "Cluster 46: Basophils - DNA binding" "Cluster 5: Breast - Unknown function" "Cluster 35: Glandular cells - Unknown function" "HPA045108: AB_2679218" "unprognostic (1.12e-1)" "unprognostic (1.18e-3)" "unprognostic (1.49e-1)" "unprognostic (6.53e-2)" "unprognostic (2.26e-2)" "unprognostic (1.65e-1)" "unprognostic (7.84e-3)" "unprognostic (5.47e-1)" "unprognostic (1.32e-1)" "unprognostic (1.51e-3)" 0.1 0.0 0.0 0.1 0.0 0.1 239.4 0.0 0.0 0.1 0.0 0.1 0.7 0.0 0.9 0.0 0.5 11.4 0.0 0.0 0.0 3.6 9.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.1 0.0 0.4 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 4.7 0.0 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.7 0.5 0.0 7.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.3 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.1 UGT2B15 UGT2B8 ENSG00000196620 "UDP glucuronosyltransferase family 2 member B15" P54855 4 68646597-68670652 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid metabolism, Steroid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 9 "gallbladder: 77.7;liver: 291.2" "Group enriched" "Detected in some" 6 "Cholangiocytes: 168.7;Hepatocytes: 142.8" "Cancer enriched" "Detected in many" 10 "liver cancer: 120.2" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045108 Uncertain NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 2: Hepatocytes - Metabolism" "HPA045108: AB_2679218" "unprognostic (1.40e-1)" "unprognostic (2.25e-1)" "unprognostic (2.22e-2)" "unprognostic (3.86e-1)" "unprognostic (1.94e-1)" "prognostic favorable (9.82e-4)" "unprognostic (6.73e-2)" "unprognostic (3.49e-2)" "unprognostic (7.84e-2)" "unprognostic (5.81e-3)" "unprognostic (2.39e-2)" "unprognostic (5.38e-2)" "prognostic favorable (4.50e-4)" 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 21.6 5.1 0.0 0.0 0.0 0.1 77.7 0.0 0.0 0.0 0.0 291.2 0.0 0.0 0.0 0.0 0.0 12.9 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.1 0.0 0.0 0.0 13.0 0.0 0.0 0.1 17.0 0.5 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.2 0.0 0.0 4.4 0.9 0.1 168.7 0.1 0.0 0.0 0.0 0.0 0.3 0.0 24.2 3.0 0.2 0.0 0.2 0.0 2.7 0.1 3.6 0.1 0.1 0.0 0.0 0.0 0.0 2.9 142.8 0.0 0.0 0.1 3.3 0.0 3.2 0.0 0.6 0.0 0.4 0.0 0.0 0.6 0.0 0.0 0.0 0.0 14.6 1.1 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.9 0.1 0.6 1.0 0.0 0.0 0.0 0.4 0.0 0.5 0.9 UGT2B17 ENSG00000197888 "UDP glucuronosyltransferase family 2 member B17" O75795 4 68537184-68568527 "Enzymes, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Lipid metabolism, Steroid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 8 "intestine: 460.0;liver: 136.2" "Group enriched" "Detected in some" 6 "Distal enterocytes: 130.1;Paneth cells: 35.1;Undifferentiated cells: 100.6" "Group enriched" "Detected in many" 7 "colorectal cancer: 16.3;liver cancer: 10.1" "Not detected" "Not detected" "Group enriched" "Detected in some" 40 "memory B-cell: 2.8;naive B-cell: 8.8" "Lineage enriched" "Detected in single" 61 "B-cells: 8.8" "Cell line enhanced" "Detected in some" "BEWO: 1.0;NB-4: 1.1;RPMI-8226: 1.7" HPA045108 Supported NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 9: Intestine - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA045108: AB_2679218" "unprognostic (1.66e-1)" "unprognostic (2.97e-2)" "unprognostic (2.96e-2)" "unprognostic (2.41e-1)" "unprognostic (1.88e-1)" "unprognostic (1.19e-2)" "unprognostic (2.36e-1)" "unprognostic (8.44e-3)" "unprognostic (9.67e-2)" "unprognostic (4.80e-3)" "unprognostic (8.52e-2)" "unprognostic (2.45e-1)" "unprognostic (6.44e-2)" "unprognostic (1.75e-1)" "unprognostic (1.76e-1)" 0.3 0.0 0.0 38.8 0.0 0.0 0.7 0.0 0.0 1.5 0.0 365.7 364.3 1.4 1.5 0.1 0.2 0.6 0.0 0.0 0.0 0.2 136.2 0.2 1.5 0.3 0.0 0.0 0.5 0.0 0.0 0.0 0.2 0.1 125.8 0.0 0.2 0.7 0.0 0.0 460.0 9.1 0.1 0.6 0.8 0.0 0.1 0.4 0.0 0.0 2.2 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.8 0.0 0.0 0.0 8.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.1 0.1 0.1 0.0 0.0 1.3 0.0 1.1 0.0 0.0 0.4 0.0 0.0 0.2 0.1 0.0 1.5 0.6 0.0 0.0 0.0 0.0 130.1 0.0 0.0 0.0 11.1 0.1 0.0 1.8 0.0 0.2 0.0 0.1 0.0 0.0 1.0 0.0 0.0 0.4 2.8 0.0 0.0 0.1 13.8 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.5 0.3 0.1 35.1 0.0 1.0 0.0 0.0 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.5 0.0 100.6 0.2 UGT2B28 ENSG00000135226 "UDP glucuronosyltransferase family 2 member B28" Q9BY64 4 69280475-69295050 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 14 "breast: 198.5" "Cell type enriched" "Detected in single" 16 "Cholangiocytes: 10.0" "Cancer enriched" "Detected in single" 8 "breast cancer: 1.9" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "eosinophil: 1.3" "Lineage enriched" "Detected in single" 13 "granulocytes: 1.3" "Group enriched" "Detected in some" 10 "Daudi: 2.9;NB-4: 2.7" HPA045108 Uncertain "Intracellular and membrane" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 5: Breast - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA045108: AB_2679218" "unprognostic (1.81e-1)" "unprognostic (1.40e-1)" "unprognostic (7.20e-3)" "unprognostic (1.51e-2)" "unprognostic (4.37e-5)" "unprognostic (9.79e-4)" 0.0 0.0 0.0 0.0 0.0 0.0 198.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 10.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT2B4 UGT2B11 ENSG00000156096 "UDP glucuronosyltransferase family 2 member B4" P06133 4 69480165-69526014 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 107 "liver: 1273.7" "Cell type enriched" "Detected in some" 22 "Hepatocytes: 883.5" "Cancer enriched" "Detected in some" 96 "liver cancer: 351.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 9 "RH-30: 4.6" "CAB033260, HPA045108" Enhanced "Intracellular and membrane" NA NA "Cluster 62: Liver - Hemostasis" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 2: Hepatocytes - Metabolism" "CAB033260: AB_2241496, HPA045108: AB_2679218" "unprognostic (7.46e-2)" "unprognostic (1.50e-1)" "unprognostic (9.37e-2)" "unprognostic (1.51e-1)" "unprognostic (2.47e-2)" "unprognostic (1.47e-1)" "unprognostic (9.43e-3)" "unprognostic (3.52e-1)" 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 11.9 0.0 0.0 1.3 1273.7 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.6 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 39.4 12.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.1 0.0 10.7 0.1 0.0 0.0 1.2 0.0 0.0 0.0 0.0 11.7 883.5 0.1 0.0 0.1 0.0 0.0 15.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.9 0.1 0.0 0.0 UGT2B7 UGT2B9 ENSG00000171234 "UDP glucuronosyltransferase family 2 member B7" P16662 4 69051363-69112987 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid metabolism, Steroid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 21 "kidney: 1299.8;liver: 1612.1" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 150.6;Glandular and luminal cells: 234.7;Hepatocytes: 550.8;Proximal tubular cells: 1249.5" "Group enriched" "Detected in many" 7 "liver cancer: 116.4;renal cancer: 101.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "RPTEC TERT1: 310.8" HPA045108 Uncertain NA NA "Cluster 81: Kidney & Liver - Metabolism" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA045108: AB_2679218" "unprognostic (1.04e-1)" "unprognostic (1.65e-1)" "prognostic favorable (7.65e-5)" "unprognostic (1.11e-2)" "unprognostic (2.10e-1)" "unprognostic (2.30e-2)" "unprognostic (5.41e-3)" "unprognostic (1.68e-1)" "unprognostic (1.74e-2)" "unprognostic (1.17e-3)" "unprognostic (1.98e-1)" "prognostic favorable (3.79e-4)" "unprognostic (1.08e-2)" "unprognostic (2.55e-1)" "unprognostic (6.23e-3)" "prognostic favorable (5.38e-4)" 0.2 0.0 0.0 0.3 0.0 0.0 2.3 0.0 0.0 32.0 0.0 3.8 68.7 8.9 24.2 0.2 49.9 10.4 0.0 0.0 0.0 1299.8 1612.1 0.4 0.0 0.0 0.0 0.1 9.9 0.0 0.0 0.1 0.0 0.3 6.9 0.0 3.6 27.5 0.0 0.3 66.6 0.3 0.0 0.0 0.9 0.1 0.0 0.9 0.0 0.0 0.2 1.6 0.0 0.0 0.0 0.3 0.2 0.3 0.0 0.0 0.2 0.0 2.5 0.0 0.0 0.3 0.0 0.0 77.6 0.0 0.0 0.0 0.0 0.1 0.0 1.0 0.0 0.1 0.0 41.9 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 2.3 0.0 0.1 0.6 0.1 310.8 2.7 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 43.2 0.0 0.0 0.0 0.2 0.3 0.2 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.7 0.1 0.6 1.6 0.0 0.0 1.2 0.6 0.1 38.6 2.1 125.0 0.0 0.0 0.0 5.7 97.8 6.6 0.3 150.6 14.0 1.0 3.5 2.7 0.4 10.6 0.0 0.1 0.0 234.7 0.0 0.0 8.9 550.8 0.1 0.0 0.3 37.3 0.0 13.8 0.0 0.0 1.8 7.6 3.6 0.0 0.0 0.0 0.0 1.5 0.4 13.0 10.7 0.0 0.0 0.6 70.6 1249.5 0.5 0.0 0.0 0.0 0.6 0.0 0.2 0.0 0.1 0.0 6.3 0.1 5.9 2.3 UROD ENSG00000126088 "Uroporphyrinogen decarboxylase" P06132 1 45010950-45015575 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Heme biosynthesis, Porphyrin biosynthesis" "Decarboxylase, Lyase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in all" 5 "Erythroid cells: 806.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "K-562: 420.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027468, HPA028668, HPA030350" Uncertain Supported Nucleoplasm,Cytosol NA NA 2600000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 1: K-562 - Erythropoiesis" "Cluster 6: Erythroid cells - Oxygen transport" "Nucleoplasm, Cytosol" "HPA027468: AB_1858654, HPA028668: AB_10603458, HPA030350: AB_2673440" "unprognostic (5.90e-2)" "unprognostic (2.94e-2)" "unprognostic (2.49e-1)" "unprognostic (9.61e-2)" "unprognostic (7.94e-2)" "unprognostic (1.96e-1)" "prognostic unfavorable (2.48e-4)" "unprognostic (2.31e-2)" "unprognostic (4.76e-2)" "unprognostic (6.75e-2)" "unprognostic (7.72e-3)" "unprognostic (3.92e-1)" "unprognostic (1.24e-1)" "unprognostic (4.68e-2)" "unprognostic (1.41e-1)" "unprognostic (8.73e-2)" "unprognostic (8.12e-2)" 51.7 120.1 72.0 25.5 73.9 199.0 48.2 72.0 79.3 40.8 77.2 49.3 29.2 46.9 54.7 34.2 49.2 30.8 70.6 73.1 74.5 58.0 100.9 34.8 35.2 72.1 73.4 51.1 45.1 115.0 42.6 39.4 73.6 35.1 30.1 24.7 61.4 44.2 75.9 31.7 30.7 54.7 72.9 37.8 38.5 44.8 73.6 44.0 54.0 83.8 36.1 40.3 32.7 73.8 66.0 42.5 67.0 89.1 113.4 107.7 31.8 87.4 209.8 163.9 125.2 59.9 32.3 46.4 82.3 122.8 116.3 31.1 127.2 153.6 116.9 42.9 133.4 245.4 95.4 200.7 132.4 79.0 42.6 115.1 97.6 154.1 132.3 121.8 208.9 92.9 420.8 48.5 157.6 53.5 49.9 62.9 104.1 51.5 145.9 76.5 96.5 69.9 141.7 54.4 73.9 57.3 89.1 63.9 134.3 73.7 50.8 77.6 137.5 96.9 71.6 34.2 130.5 49.4 60.1 38.1 141.0 117.6 47.2 72.3 111.9 65.5 57.4 81.5 58.8 84.9 69.2 56.7 149.7 81.9 63.6 58.0 20.1 87.4 50.9 102.3 88.7 122.1 72.0 73.9 72.0 79.3 73.1 74.5 72.1 73.4 73.6 72.9 73.6 73.8 25.8 44.8 38.0 7.8 25.4 22.9 35.8 101.4 43.9 27.3 31.0 37.1 74.4 41.5 45.3 27.6 16.7 98.6 22.1 21.4 90.1 73.5 8.1 20.3 30.7 42.7 18.0 806.8 9.4 63.7 54.6 57.1 17.3 21.2 52.6 20.4 38.6 98.5 101.8 13.5 6.7 20.2 73.2 37.9 29.4 16.2 79.6 38.5 48.0 5.6 103.6 89.7 24.7 7.1 7.3 51.2 23.7 56.1 36.8 15.9 32.7 134.5 32.9 25.3 39.5 29.4 75.0 37.3 42.3 31.6 24.7 49.8 23.3 72.7 20.9 29.1 ZADH2 MGC45594 ENSG00000180011 "Zinc binding alcohol dehydrogenase domain containing 2" Q8N4Q0 18 75195113-75209139 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021468, HPA053646" Uncertain Approved "Nucleoplasm,Golgi apparatus,Vesicles" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 44: HDLM-2 - Immune response" "Cluster 33: Fibroblasts - ECM organization" Vesicles "Nucleoplasm, Golgi apparatus" "HPA021468: AB_1858932, HPA053646: AB_2682216" "unprognostic (3.22e-2)" "unprognostic (1.03e-2)" "unprognostic (7.14e-2)" "unprognostic (1.13e-1)" "unprognostic (4.79e-1)" "unprognostic (5.11e-3)" "unprognostic (1.15e-1)" "unprognostic (1.49e-1)" "unprognostic (3.62e-3)" "unprognostic (1.42e-1)" "unprognostic (3.05e-2)" "unprognostic (1.48e-1)" "prognostic favorable (1.02e-6)" "unprognostic (3.41e-1)" "unprognostic (1.87e-1)" "prognostic unfavorable (1.94e-4)" "unprognostic (2.23e-1)" 17.7 12.9 15.6 11.8 17.8 20.7 22.2 19.2 22.0 18.8 14.0 26.3 19.0 15.5 24.8 20.0 17.9 15.8 34.3 17.0 12.9 24.2 32.5 16.3 19.3 16.8 13.9 23.9 26.6 24.7 21.5 36.6 18.3 17.1 28.7 30.6 23.8 18.2 44.9 22.0 26.0 15.2 16.5 16.1 21.3 7.0 15.5 23.3 27.8 40.7 20.6 16.6 16.9 16.8 21.7 14.1 14.8 30.4 22.6 29.0 16.3 38.5 44.6 14.8 18.5 8.7 30.0 15.2 6.0 38.3 17.4 28.7 18.5 32.6 10.4 94.6 27.1 34.1 32.7 17.0 16.0 58.0 33.2 32.2 31.9 11.9 27.2 27.5 30.9 35.2 18.6 54.0 28.6 25.5 14.6 28.6 3.8 20.9 31.9 31.0 23.7 50.2 28.9 36.2 27.2 22.4 21.4 21.7 24.5 10.4 21.8 28.4 27.7 28.9 22.0 9.2 12.4 8.8 41.2 10.5 19.1 49.5 23.8 1.7 3.4 8.9 3.2 2.9 2.3 2.1 2.6 2.9 2.3 1.5 1.4 2.2 1.7 1.7 3.8 1.7 3.2 1.8 15.6 17.8 19.2 22.0 17.0 12.9 16.8 13.9 18.3 16.5 15.5 16.8 41.5 35.3 17.9 12.4 7.5 9.7 18.7 13.9 9.6 59.0 15.3 10.8 56.3 20.0 12.5 27.6 6.2 8.4 15.9 24.8 19.6 12.3 0.5 8.5 39.0 24.1 23.4 9.9 16.6 21.1 8.1 26.4 12.8 11.1 7.0 42.6 23.6 25.0 16.4 25.2 14.1 25.1 14.2 20.2 19.1 2.1 36.7 18.3 12.4 12.2 23.9 21.3 13.4 20.6 14.9 15.5 21.9 63.2 6.2 18.5 35.2 19.0 8.1 40.9 19.7 25.5 12.3 0.4 4.9 23.7 11.1 6.7 11.0 73.0 27.2 20.9