Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific nTPM" "RNA single cell type specificity" "RNA single cell type distribution" "RNA single cell type specificity score" "RNA single cell type specific nTPM" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific nTPM" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific nTPM" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific nTPM" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific nTPM" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific nTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific nTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "CCD Protein" "CCD Transcript" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Blood expression cluster" "Tissue expression cluster" "Cell line expression cluster" "Single cell expression cluster" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [nTPM]" "Tissue RNA - adrenal gland [nTPM]" "Tissue RNA - amygdala [nTPM]" "Tissue RNA - appendix [nTPM]" "Tissue RNA - basal ganglia [nTPM]" "Tissue RNA - bone marrow [nTPM]" "Tissue RNA - breast [nTPM]" "Tissue RNA - cerebellum [nTPM]" "Tissue RNA - cerebral cortex [nTPM]" "Tissue RNA - cervix [nTPM]" "Tissue RNA - choroid plexus [nTPM]" "Tissue RNA - colon [nTPM]" "Tissue RNA - duodenum [nTPM]" "Tissue RNA - endometrium 1 [nTPM]" "Tissue RNA - epididymis [nTPM]" "Tissue RNA - esophagus [nTPM]" "Tissue RNA - fallopian tube [nTPM]" "Tissue RNA - gallbladder [nTPM]" "Tissue RNA - heart muscle [nTPM]" "Tissue RNA - hippocampal formation [nTPM]" "Tissue RNA - hypothalamus [nTPM]" "Tissue RNA - kidney [nTPM]" "Tissue RNA - liver [nTPM]" "Tissue RNA - lung [nTPM]" "Tissue RNA - lymph node [nTPM]" "Tissue RNA - medulla oblongata [nTPM]" "Tissue RNA - midbrain [nTPM]" "Tissue RNA - ovary [nTPM]" "Tissue RNA - pancreas [nTPM]" "Tissue RNA - parathyroid gland [nTPM]" "Tissue RNA - pituitary gland [nTPM]" "Tissue RNA - placenta [nTPM]" "Tissue RNA - pons [nTPM]" "Tissue RNA - prostate [nTPM]" "Tissue RNA - rectum [nTPM]" "Tissue RNA - retina [nTPM]" "Tissue RNA - salivary gland [nTPM]" "Tissue RNA - seminal vesicle [nTPM]" "Tissue RNA - skeletal muscle [nTPM]" "Tissue RNA - skin 1 [nTPM]" "Tissue RNA - small intestine [nTPM]" "Tissue RNA - smooth muscle [nTPM]" "Tissue RNA - spinal cord [nTPM]" "Tissue RNA - spleen [nTPM]" "Tissue RNA - stomach 1 [nTPM]" "Tissue RNA - testis [nTPM]" "Tissue RNA - thalamus [nTPM]" "Tissue RNA - thymus [nTPM]" "Tissue RNA - thyroid gland [nTPM]" "Tissue RNA - tongue [nTPM]" "Tissue RNA - tonsil [nTPM]" "Tissue RNA - urinary bladder [nTPM]" "Tissue RNA - vagina [nTPM]" "Tissue RNA - white matter [nTPM]" "Cell RNA - A-431 [nTPM]" "Cell RNA - A549 [nTPM]" "Cell RNA - AF22 [nTPM]" "Cell RNA - AN3-CA [nTPM]" "Cell RNA - ASC diff [nTPM]" "Cell RNA - ASC TERT1 [nTPM]" "Cell RNA - BEWO [nTPM]" "Cell RNA - BJ [nTPM]" "Cell RNA - BJ hTERT+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]" "Cell RNA - CACO-2 [nTPM]" "Cell RNA - CAPAN-2 [nTPM]" "Cell RNA - Daudi [nTPM]" "Cell RNA - EFO-21 [nTPM]" "Cell RNA - fHDF/TERT166 [nTPM]" "Cell RNA - GAMG [nTPM]" "Cell RNA - HaCaT [nTPM]" "Cell RNA - HAP1 [nTPM]" "Cell RNA - HBEC3-KT [nTPM]" "Cell RNA - HBF TERT88 [nTPM]" "Cell RNA - HDLM-2 [nTPM]" "Cell RNA - HEK 293 [nTPM]" "Cell RNA - HEL [nTPM]" "Cell RNA - HeLa [nTPM]" "Cell RNA - Hep G2 [nTPM]" "Cell RNA - HHSteC [nTPM]" "Cell RNA - HL-60 [nTPM]" "Cell RNA - HMC-1 [nTPM]" "Cell RNA - HSkMC [nTPM]" "Cell RNA - hTCEpi [nTPM]" "Cell RNA - hTEC/SVTERT24-B [nTPM]" "Cell RNA - hTERT-HME1 [nTPM]" "Cell RNA - hTERT-RPE1 [nTPM]" "Cell RNA - HUVEC TERT2 [nTPM]" "Cell RNA - JURKAT [nTPM]" "Cell RNA - K-562 [nTPM]" "Cell RNA - Karpas-707 [nTPM]" "Cell RNA - LHCN-M2 [nTPM]" "Cell RNA - MCF7 [nTPM]" "Cell RNA - MOLT-4 [nTPM]" "Cell RNA - NB-4 [nTPM]" "Cell RNA - NTERA-2 [nTPM]" "Cell RNA - OE19 [nTPM]" "Cell RNA - PC-3 [nTPM]" "Cell RNA - REH [nTPM]" "Cell RNA - RH-30 [nTPM]" "Cell RNA - RPMI-8226 [nTPM]" "Cell RNA - RPTEC TERT1 [nTPM]" "Cell RNA - RT4 [nTPM]" "Cell RNA - SCLC-21H [nTPM]" "Cell RNA - SH-SY5Y [nTPM]" "Cell RNA - SiHa [nTPM]" "Cell RNA - SK-BR-3 [nTPM]" "Cell RNA - SK-MEL-30 [nTPM]" "Cell RNA - SuSa [nTPM]" "Cell RNA - T-47d [nTPM]" "Cell RNA - THP-1 [nTPM]" "Cell RNA - TIME [nTPM]" "Cell RNA - U-138 MG [nTPM]" "Cell RNA - U-2 OS [nTPM]" "Cell RNA - U-2197 [nTPM]" "Cell RNA - U-251 MG [nTPM]" "Cell RNA - U-266/70 [nTPM]" "Cell RNA - U-266/84 [nTPM]" "Cell RNA - U-698 [nTPM]" "Cell RNA - U-87 MG [nTPM]" "Cell RNA - U-937 [nTPM]" "Cell RNA - WM-115 [nTPM]" "Blood RNA - basophil [nTPM]" "Blood RNA - classical monocyte [nTPM]" "Blood RNA - eosinophil [nTPM]" "Blood RNA - gdT-cell [nTPM]" "Blood RNA - intermediate monocyte [nTPM]" "Blood RNA - MAIT T-cell [nTPM]" "Blood RNA - memory B-cell [nTPM]" "Blood RNA - memory CD4 T-cell [nTPM]" "Blood RNA - memory CD8 T-cell [nTPM]" "Blood RNA - myeloid DC [nTPM]" "Blood RNA - naive B-cell [nTPM]" "Blood RNA - naive CD4 T-cell [nTPM]" "Blood RNA - naive CD8 T-cell [nTPM]" "Blood RNA - neutrophil [nTPM]" "Blood RNA - NK-cell [nTPM]" "Blood RNA - non-classical monocyte [nTPM]" "Blood RNA - plasmacytoid DC [nTPM]" "Blood RNA - T-reg [nTPM]" "Blood RNA - total PBMC [nTPM]" "Brain RNA - amygdala [nTPM]" "Brain RNA - basal ganglia [nTPM]" "Brain RNA - cerebellum [nTPM]" "Brain RNA - cerebral cortex [nTPM]" "Brain RNA - hippocampal formation [nTPM]" "Brain RNA - hypothalamus [nTPM]" "Brain RNA - medulla oblongata [nTPM]" "Brain RNA - midbrain [nTPM]" "Brain RNA - pons [nTPM]" "Brain RNA - spinal cord [nTPM]" "Brain RNA - thalamus [nTPM]" "Brain RNA - white matter [nTPM]" "Single Cell Type RNA - Adipocytes [nTPM]" "Single Cell Type RNA - Alveolar cells type 1 [nTPM]" "Single Cell Type RNA - Alveolar cells type 2 [nTPM]" "Single Cell Type RNA - Astrocytes [nTPM]" "Single Cell Type RNA - B-cells [nTPM]" "Single Cell Type RNA - Basal keratinocytes [nTPM]" "Single Cell Type RNA - Basal prostatic cells [nTPM]" "Single Cell Type RNA - Basal respiratory cells [nTPM]" "Single Cell Type RNA - Basal squamous epithelial cells [nTPM]" "Single Cell Type RNA - Bipolar cells [nTPM]" "Single Cell Type RNA - Breast glandular cells [nTPM]" "Single Cell Type RNA - Breast myoepithelial cells [nTPM]" "Single Cell Type RNA - Cardiomyocytes [nTPM]" "Single Cell Type RNA - Cholangiocytes [nTPM]" "Single Cell Type RNA - Club cells [nTPM]" "Single Cell Type RNA - Collecting duct cells [nTPM]" "Single Cell Type RNA - Cone photoreceptor cells [nTPM]" "Single Cell Type RNA - Cytotrophoblasts [nTPM]" "Single Cell Type RNA - dendritic cells [nTPM]" "Single Cell Type RNA - Distal enterocytes [nTPM]" "Single Cell Type RNA - Distal tubular cells [nTPM]" "Single Cell Type RNA - Ductal cells [nTPM]" "Single Cell Type RNA - Early spermatids [nTPM]" "Single Cell Type RNA - Endometrial ciliated cells [nTPM]" "Single Cell Type RNA - Endometrial stromal cells [nTPM]" "Single Cell Type RNA - Endothelial cells [nTPM]" "Single Cell Type RNA - Enteroendocrine cells [nTPM]" "Single Cell Type RNA - Erythroid cells [nTPM]" "Single Cell Type RNA - Excitatory neurons [nTPM]" "Single Cell Type RNA - Exocrine glandular cells [nTPM]" "Single Cell Type RNA - Extravillous trophoblasts [nTPM]" "Single Cell Type RNA - Fibroblasts [nTPM]" "Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]" "Single Cell Type RNA - Glandular and luminal cells [nTPM]" "Single Cell Type RNA - granulocytes [nTPM]" "Single Cell Type RNA - Granulosa cells [nTPM]" "Single Cell Type RNA - Hepatic stellate cells [nTPM]" "Single Cell Type RNA - Hepatocytes [nTPM]" "Single Cell Type RNA - Hofbauer cells [nTPM]" "Single Cell Type RNA - Horizontal cells [nTPM]" "Single Cell Type RNA - Inhibitory neurons [nTPM]" "Single Cell Type RNA - Intestinal goblet cells [nTPM]" "Single Cell Type RNA - Ionocytes [nTPM]" "Single Cell Type RNA - Kupffer cells [nTPM]" "Single Cell Type RNA - Langerhans cells [nTPM]" "Single Cell Type RNA - Late spermatids [nTPM]" "Single Cell Type RNA - Leydig cells [nTPM]" "Single Cell Type RNA - Macrophages [nTPM]" "Single Cell Type RNA - Melanocytes [nTPM]" "Single Cell Type RNA - Microglial cells [nTPM]" "Single Cell Type RNA - monocytes [nTPM]" "Single Cell Type RNA - Muller glia cells [nTPM]" "Single Cell Type RNA - NK-cells [nTPM]" "Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]" "Single Cell Type RNA - Oligodendrocytes [nTPM]" "Single Cell Type RNA - Pancreatic endocrine cells [nTPM]" "Single Cell Type RNA - Paneth cells [nTPM]" "Single Cell Type RNA - Peritubular cells [nTPM]" "Single Cell Type RNA - Plasma cells [nTPM]" "Single Cell Type RNA - Prostatic glandular cells [nTPM]" "Single Cell Type RNA - Proximal enterocytes [nTPM]" "Single Cell Type RNA - Proximal tubular cells [nTPM]" "Single Cell Type RNA - Respiratory ciliated cells [nTPM]" "Single Cell Type RNA - Rod photoreceptor cells [nTPM]" "Single Cell Type RNA - Sertoli cells [nTPM]" "Single Cell Type RNA - Skeletal myocytes [nTPM]" "Single Cell Type RNA - Smooth muscle cells [nTPM]" "Single Cell Type RNA - Spermatocytes [nTPM]" "Single Cell Type RNA - Spermatogonia [nTPM]" "Single Cell Type RNA - Squamous epithelial cells [nTPM]" "Single Cell Type RNA - Suprabasal keratinocytes [nTPM]" "Single Cell Type RNA - Syncytiotrophoblasts [nTPM]" "Single Cell Type RNA - T-cells [nTPM]" "Single Cell Type RNA - Theca cells [nTPM]" "Single Cell Type RNA - Undifferentiated cells [nTPM]" "Single Cell Type RNA - Urothelial cells [nTPM]" ACP2 LAP ENSG00000134575 "Acid phosphatase 2, lysosomal" P11117 11 47239302-47248906 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hepatocytes: 89.3;Hofbauer cells: 113.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "intermediate monocyte: 69.9" "Lineage enriched" "Detected in all" 5 "monocytes: 69.9" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA 12000 "Cluster 51: Monocytes - Innate immune response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 44: HDLM-2 - Immune response" "Cluster 4: Macrophages - Innate immune response" "unprognostic (5.27e-3)" "unprognostic (1.56e-1)" "unprognostic (3.86e-2)" "prognostic favorable (1.04e-4)" "unprognostic (7.90e-3)" "unprognostic (2.93e-1)" "unprognostic (6.16e-3)" "unprognostic (1.09e-1)" "unprognostic (2.63e-1)" "unprognostic (3.28e-3)" "unprognostic (2.64e-3)" "unprognostic (5.42e-2)" "unprognostic (1.07e-2)" "unprognostic (1.79e-1)" "unprognostic (1.20e-1)" "unprognostic (8.68e-3)" "unprognostic (1.57e-1)" 25.2 36.6 17.3 22.9 17.1 6.4 21.8 17.0 18.5 16.5 22.1 23.3 42.9 15.8 29.8 14.3 14.1 19.6 21.7 19.8 26.0 27.4 80.5 21.4 29.4 20.8 19.6 11.1 45.9 21.3 21.3 28.7 23.1 25.4 18.1 11.9 50.3 18.3 14.0 11.4 31.9 16.9 16.9 29.1 24.8 12.2 22.0 13.7 19.3 14.8 15.3 22.0 13.1 17.2 16.5 33.5 31.9 28.2 28.1 13.6 24.4 26.6 47.1 47.5 49.4 23.3 26.3 4.3 21.9 34.2 14.3 23.7 16.9 24.6 22.5 85.5 29.1 11.1 48.1 24.6 38.4 16.4 27.1 34.1 15.2 24.6 14.5 28.3 34.9 14.1 20.3 33.9 31.5 26.8 13.4 14.2 21.5 24.8 20.0 10.8 43.1 36.2 34.9 37.6 16.7 26.0 36.8 80.1 19.2 16.3 49.0 14.0 21.0 23.9 19.8 31.4 38.4 28.1 40.0 3.6 35.0 8.2 37.6 12.5 16.9 7.2 12.3 69.9 9.4 2.5 7.6 11.1 15.1 1.5 6.6 5.7 2.8 9.7 48.2 0.6 8.3 10.9 17.3 17.1 17.0 18.5 19.8 26.0 20.8 19.6 23.1 16.9 22.0 17.2 13.3 19.2 18.6 6.2 5.6 4.1 9.3 42.2 10.2 14.4 13.5 9.1 9.2 21.5 29.4 18.4 6.2 41.3 2.6 37.6 9.8 50.6 1.8 7.7 15.6 18.3 15.0 13.5 6.9 60.1 33.3 15.3 17.3 12.1 12.0 10.7 45.7 89.3 113.5 11.8 8.9 26.7 22.4 80.0 3.9 3.5 5.0 33.8 24.9 3.7 29.8 20.6 7.2 8.5 4.3 33.5 29.5 10.5 21.1 10.9 55.3 33.4 19.2 11.9 19.7 8.1 14.5 11.8 19.1 9.5 2.4 29.3 5.8 25.2 14.3 8.6 ADA ADA1 ENSG00000196839 "Adenosine deaminase" P00813 20 44619522-44652233 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell adhesion, Nucleotide metabolism" Hydrolase "Disease variant, FDA approved drug targets, Hereditary hemolytic anemia, SCID" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 8 "intestine: 507.2;lymphoid tissue: 259.0" "Cell type enhanced" "Detected in many" "dendritic cells: 76.4;Extravillous trophoblasts: 128.2;NK-cells: 56.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "intermediate monocyte: 168.5;NK-cell: 94.5;non-classical monocyte: 362.8;plasmacytoid DC: 218.6" "Group enriched" "Detected in all" 4 "dendritic cells: 218.6;monocytes: 362.8;NK-cells: 94.5" "Group enriched" "Detected in many" 5 "JURKAT: 570.9;MOLT-4: 1915.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA001399, CAB004307, HPA023884" Enhanced Supported "Plasma membrane,Cytosol" No No 470000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 9: Intestine - Unknown function" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 38: Extravillous trophoblasts - Unknown function" "Plasma membrane" Cytosol "CAB004307: AB_626634, HPA001399: AB_1078099, HPA023884: AB_1844573" "unprognostic (4.30e-2)" "unprognostic (6.89e-2)" "unprognostic (3.96e-2)" "prognostic unfavorable (1.23e-7)" "unprognostic (9.33e-2)" "unprognostic (9.07e-3)" "prognostic unfavorable (6.77e-5)" "prognostic unfavorable (2.20e-4)" "unprognostic (1.59e-1)" "unprognostic (2.16e-1)" "unprognostic (3.66e-2)" "unprognostic (3.48e-1)" "prognostic unfavorable (2.94e-14)" "unprognostic (2.29e-1)" "unprognostic (1.04e-2)" "unprognostic (1.53e-1)" "unprognostic (1.82e-1)" 16.6 6.3 6.9 18.5 8.2 20.2 10.9 6.8 9.4 7.3 5.6 5.7 507.2 3.8 1.7 9.0 5.6 9.2 17.8 6.9 7.0 3.3 4.4 6.2 33.4 7.2 8.2 2.1 5.3 1.5 1.3 4.6 7.2 4.3 3.6 0.3 4.7 2.8 5.3 6.0 17.9 5.7 6.1 17.5 46.0 2.4 8.7 259.0 5.8 6.4 26.4 9.3 5.4 8.8 14.0 37.7 19.2 13.2 35.6 48.7 30.5 13.7 7.8 13.2 9.3 17.5 14.8 38.4 15.8 17.9 24.7 2.2 13.2 55.1 7.3 2.9 17.2 7.8 6.6 13.5 15.0 6.3 20.3 234.3 23.2 5.1 9.0 12.6 50.3 570.9 20.4 30.7 6.0 33.1 1915.5 28.9 5.2 17.2 13.5 102.3 25.8 95.0 2.3 0.0 0.7 9.3 20.2 4.4 24.2 24.0 4.5 19.1 16.9 10.1 18.6 20.5 2.8 40.1 27.3 82.3 3.5 32.5 9.0 0.5 9.8 1.2 43.3 168.5 27.8 7.5 35.5 51.0 35.2 7.6 27.3 38.6 2.5 94.5 362.8 218.6 29.8 57.4 6.9 8.2 6.8 9.4 6.9 7.0 7.2 8.2 7.2 6.1 8.7 8.8 18.2 0.0 1.9 2.9 13.5 12.9 3.4 10.0 13.6 0.0 2.7 3.2 2.1 0.0 4.8 1.8 0.0 2.9 76.4 0.8 0.0 3.7 0.4 0.7 9.1 17.0 0.0 10.7 0.2 19.7 128.2 19.7 14.8 0.8 0.0 3.5 7.1 3.6 28.5 0.0 0.2 1.5 10.2 20.8 25.5 1.8 42.3 27.6 8.8 3.7 37.4 3.8 56.7 0.5 9.4 10.7 0.3 2.6 31.4 6.0 0.7 3.0 2.4 0.0 13.1 1.9 14.1 0.3 6.2 12.9 13.9 3.7 30.9 6.8 4.9 2.7 ADK AK ENSG00000156110 "Adenosine kinase" P55263 10 74151202-74709963 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Purine salvage" "Kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 151.2" "Cell type enhanced" "Detected in all" "Excitatory neurons: 245.3;Inhibitory neurons: 287.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032876, HPA038391, HPA038409, HPA075222" Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA 920000 "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Cytosol" "Plasma membrane" "CAB032876: AB_2242229, HPA038391: AB_2675990, HPA038409: AB_10675798, HPA075222: " "unprognostic (1.55e-3)" "unprognostic (1.09e-1)" "unprognostic (1.88e-1)" "unprognostic (2.62e-2)" "unprognostic (2.52e-2)" "prognostic unfavorable (1.93e-4)" "prognostic favorable (9.91e-4)" "unprognostic (2.64e-1)" "unprognostic (2.88e-1)" "unprognostic (1.55e-1)" "unprognostic (8.15e-3)" "unprognostic (2.51e-1)" "unprognostic (1.89e-3)" "unprognostic (2.03e-1)" "unprognostic (2.88e-2)" "unprognostic (4.97e-3)" "unprognostic (2.95e-2)" 23.9 15.5 13.0 16.9 18.7 28.6 27.4 13.5 17.7 17.5 11.6 17.9 16.9 10.8 16.5 47.3 16.5 11.4 27.2 13.9 15.2 35.8 151.2 24.4 22.8 14.0 15.0 8.3 18.8 44.2 14.9 26.6 16.5 14.9 19.5 16.1 20.0 16.0 41.5 33.9 12.4 14.8 14.2 15.0 12.1 15.5 14.1 27.0 38.2 47.1 34.5 24.5 24.7 15.8 177.3 37.4 37.2 50.5 37.1 54.7 88.2 140.8 105.4 103.8 114.5 114.0 172.6 86.3 34.2 57.7 51.3 151.1 44.1 150.1 167.0 59.1 51.3 55.6 59.8 122.8 41.7 87.6 22.5 51.1 95.5 77.4 191.7 79.0 91.2 38.7 41.8 28.4 78.8 101.7 102.5 129.0 9.9 80.0 276.3 100.6 63.7 69.4 117.1 92.7 29.5 33.8 63.6 239.7 49.5 34.7 159.7 69.3 82.8 34.3 67.0 93.2 123.0 40.5 48.3 98.1 65.0 127.6 22.1 2.3 34.2 4.1 12.9 65.5 29.9 103.7 28.2 24.1 83.1 155.0 21.3 19.2 11.1 20.7 80.4 57.6 55.7 36.3 13.0 18.7 13.5 17.7 13.9 15.2 14.0 15.0 16.5 14.2 14.1 15.8 9.8 83.3 75.8 136.5 84.2 94.2 73.5 102.0 105.9 16.3 26.2 26.0 67.8 38.6 72.4 31.3 56.3 136.7 25.9 11.0 92.0 83.2 80.7 40.6 18.8 14.9 10.8 27.7 245.3 67.5 139.5 27.0 23.0 55.6 21.5 9.7 17.2 130.1 39.3 11.8 287.7 12.1 44.7 25.2 50.0 26.9 16.8 33.7 48.0 198.6 44.1 14.1 11.3 140.8 165.4 62.7 10.4 12.0 39.1 92.1 5.0 64.5 33.5 25.0 6.6 20.4 26.0 17.4 14.3 96.7 97.0 107.3 32.7 17.0 20.5 66.3 ADPRM "C17orf48, MDS006" ENSG00000170222 "ADP-ribose/CDP-alcohol diphosphatase, manganese dependent" Q3LIE5 17 10697594-10711558 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Rod photoreceptor cells: 34.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023265, HPA023820" Approved NA NA "Cluster 32: T-cells - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 30: Epithelial cell lines - Translation" "Cluster 32: Non-specific - Translation" "HPA023265: AB_1845590, HPA023820: AB_1845591" "unprognostic (7.58e-3)" "prognostic favorable (1.69e-4)" "unprognostic (1.42e-1)" "prognostic favorable (2.38e-5)" "unprognostic (2.49e-1)" "unprognostic (1.30e-1)" "unprognostic (1.31e-1)" "unprognostic (1.35e-1)" "unprognostic (1.43e-2)" "unprognostic (1.43e-1)" "unprognostic (6.26e-3)" "unprognostic (2.97e-1)" "unprognostic (6.53e-3)" "unprognostic (2.65e-2)" "unprognostic (1.83e-1)" "unprognostic (4.77e-2)" "unprognostic (5.97e-2)" 6.7 4.6 1.9 4.9 2.2 6.6 6.6 2.0 2.3 6.8 1.7 5.1 3.1 6.4 3.7 4.4 4.8 4.7 3.6 1.9 2.1 4.5 6.8 3.9 6.9 1.9 1.8 7.8 6.9 3.1 3.9 2.6 1.9 7.7 3.2 9.9 4.7 3.5 9.2 5.4 6.0 2.8 2.0 5.8 7.9 4.0 2.2 7.0 6.5 6.4 5.6 4.8 5.2 2.4 3.8 2.8 3.9 5.0 8.8 11.1 1.9 7.2 7.7 5.2 7.5 1.5 1.7 7.1 3.3 7.5 2.2 3.0 1.8 5.2 6.4 4.4 5.4 3.5 2.9 4.3 14.7 2.6 4.3 13.7 7.5 5.6 7.8 8.0 9.6 7.8 3.4 0.6 6.8 1.1 2.8 4.5 4.2 2.5 1.5 3.1 2.7 1.9 9.1 2.5 0.7 5.2 3.5 1.3 8.2 4.7 3.6 5.0 9.8 2.9 2.3 3.6 4.2 1.6 1.1 1.1 6.9 3.6 6.1 2.6 2.5 4.7 2.4 2.6 3.5 5.9 6.2 4.1 3.1 7.2 13.0 8.5 2.3 4.1 2.3 1.7 5.9 3.9 1.9 2.2 2.0 2.3 1.9 2.1 1.9 1.8 1.9 2.0 2.2 2.4 5.8 3.2 2.0 6.5 17.6 5.2 11.7 17.4 8.0 11.7 5.9 6.0 2.7 4.3 8.9 1.8 18.8 7.2 6.4 3.8 3.9 8.4 10.2 1.9 3.9 5.7 4.8 6.7 6.0 8.3 7.3 6.6 4.6 2.4 14.0 4.4 7.1 9.8 6.7 3.3 6.9 7.5 2.0 9.5 5.1 5.2 15.8 6.0 10.6 1.9 11.1 13.5 6.2 8.0 8.1 8.1 4.6 8.2 3.6 12.7 14.9 8.5 4.1 34.3 6.6 6.6 14.0 12.5 10.2 4.4 4.7 8.2 13.0 4.4 5.6 11.4 AICDA "AID, ARP2, CDA2, HIGM2" ENSG00000111732 "Activation induced cytidine deaminase" Q9GZX7 12 8602170-8612867 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "mRNA processing" Hydrolase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 10 "lymphoid tissue: 15.4" "Cell type enhanced" "Detected in single" "Proximal enterocytes: 2.6" "Cancer enhanced" "Detected in single" "testis cancer: 0.8" "Low region specificity" "Detected in single" "Group enriched" "Detected in some" 5 "memory B-cell: 1.9;naive B-cell: 3.8" "Lineage enriched" "Detected in single" 6 "B-cells: 3.8" "Group enriched" "Detected in some" 7 "Daudi: 142.5;U-698: 118.4" "Not detected" "Not detected" "Low region specificity" "Detected in some" NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 16: Immune cells - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 50: Fibroblasts - ECM organization" "unprognostic (2.71e-2)" "unprognostic (1.39e-2)" "unprognostic (7.76e-2)" "unprognostic (1.68e-1)" "unprognostic (8.73e-3)" "unprognostic (1.11e-1)" "unprognostic (4.05e-2)" "unprognostic (9.69e-2)" "unprognostic (1.96e-2)" "unprognostic (4.04e-6)" "unprognostic (8.82e-2)" "unprognostic (1.28e-1)" "unprognostic (4.21e-1)" "unprognostic (4.65e-1)" 0.2 0.1 0.4 3.7 0.3 0.6 0.0 1.2 0.6 0.0 0.1 0.2 0.2 0.2 0.2 0.2 0.0 0.5 0.3 0.3 0.1 0.0 0.1 0.2 15.4 0.2 0.3 0.0 0.1 0.0 0.0 0.3 0.3 0.0 0.1 0.2 0.3 0.0 1.4 0.3 0.8 0.0 0.0 0.7 0.2 0.2 0.3 0.4 0.2 0.0 12.0 0.1 0.1 0.6 0.1 0.0 0.1 0.2 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.1 142.5 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 5.3 0.2 0.1 0.0 2.0 19.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.2 0.2 0.0 0.2 0.2 0.5 0.1 0.2 0.1 0.1 0.0 0.2 0.1 0.1 1.3 0.1 0.1 0.6 0.1 0.4 0.5 0.1 0.0 0.1 118.4 0.0 0.3 0.1 0.5 0.2 0.1 0.1 0.1 0.0 1.9 0.1 0.0 0.1 3.8 0.1 0.1 0.6 0.1 0.1 0.2 0.1 0.2 0.4 0.3 1.2 0.6 0.3 0.1 0.2 0.3 0.3 0.0 0.3 0.6 0.2 0.0 0.6 0.0 0.9 0.3 0.6 0.0 0.0 0.4 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.3 0.9 0.0 0.6 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.8 0.1 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 2.6 0.2 0.0 0.7 0.0 0.8 0.1 0.0 0.4 0.0 0.1 0.0 0.3 0.0 0.1 0.3 AK3 "AK3L1, AK6, AKL3L1" ENSG00000147853 "Adenylate kinase 3" Q9UIJ7 9 4709556-4742043 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 242.8" "Cell type enhanced" "Detected in all" "Hepatocytes: 305.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 485.4;HEL: 273.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063324 Enhanced Supported Mitochondria NA NA 31000 "Cluster 15: NK-cells - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 44: HDLM-2 - Immune response" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "HPA063324: AB_2684985" "unprognostic (1.30e-2)" "unprognostic (2.25e-1)" "unprognostic (1.28e-1)" "unprognostic (1.06e-1)" "unprognostic (6.55e-2)" "unprognostic (1.02e-1)" "unprognostic (2.21e-3)" "unprognostic (6.44e-2)" "unprognostic (2.81e-2)" "unprognostic (9.81e-3)" "unprognostic (1.90e-1)" "unprognostic (2.76e-2)" "prognostic favorable (6.07e-9)" "unprognostic (1.24e-1)" "unprognostic (1.40e-1)" "unprognostic (1.39e-1)" "unprognostic (1.55e-3)" 75.5 62.9 30.1 23.7 36.9 20.1 39.7 33.5 34.9 41.0 56.2 67.4 68.3 41.9 31.2 61.2 34.4 35.9 100.6 27.0 40.6 101.4 199.9 34.9 29.6 32.8 38.1 47.8 38.9 66.8 22.2 35.1 33.7 49.2 59.6 16.8 38.7 42.6 242.8 47.4 62.5 41.7 33.5 33.0 69.5 11.2 37.9 35.1 49.9 159.6 34.4 48.7 39.7 36.5 44.1 30.7 55.5 22.6 75.3 55.5 4.9 60.4 116.1 30.4 45.5 5.7 43.6 39.5 20.4 63.5 16.6 29.3 40.8 48.0 51.2 485.4 37.1 273.3 56.1 91.3 58.5 28.7 14.1 87.9 41.4 26.4 36.0 70.4 91.2 38.2 22.1 49.6 91.8 22.5 27.5 65.6 53.3 77.1 15.4 38.2 21.1 19.2 82.1 55.7 98.3 63.6 65.7 18.5 35.1 53.7 26.5 53.2 65.9 25.7 28.8 70.1 43.6 15.5 10.5 50.3 46.9 19.9 18.9 13.3 10.2 32.2 27.6 8.1 25.5 12.1 21.6 25.7 19.6 12.3 28.4 29.2 2.8 27.4 6.5 26.3 31.8 21.1 30.1 36.9 33.5 34.9 27.0 40.6 32.8 38.1 33.7 33.5 37.9 36.5 58.3 57.7 80.3 78.0 34.0 74.2 76.4 87.4 84.2 10.7 58.8 28.3 182.9 68.6 71.0 66.2 22.9 95.5 34.6 129.9 258.2 84.8 3.7 40.7 30.6 65.7 109.6 68.1 23.4 69.6 17.0 83.4 87.1 37.8 46.2 75.8 79.2 305.6 47.5 15.2 55.8 104.2 73.2 46.9 41.4 4.5 108.7 34.7 74.7 22.5 40.9 28.2 33.0 44.7 87.0 67.3 78.7 149.7 62.8 166.7 111.8 183.5 52.8 11.0 105.2 76.0 60.8 6.4 14.1 152.5 104.4 214.0 36.4 68.5 145.5 151.6 AK5 ENSG00000154027 "Adenylate kinase 5" Q9Y6K8 1 77282019-77559966 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "brain: 121.0" "Cell type enhanced" "Detected in many" "Early spermatids: 150.5;Excitatory neurons: 403.7;Inhibitory neurons: 167.3;Oligodendrocytes: 706.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "myeloid DC: 13.6;naive CD4 T-cell: 16.3" "Group enriched" "Detected in many" 12 "dendritic cells: 13.6;T-cells: 16.3" "Cell line enhanced" "Detected in many" "ASC TERT1: 93.7;BJ: 67.8;fHDF/TERT166: 77.5;LHCN-M2: 189.9;U-2 OS: 58.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019128, HPA057255" Enhanced Supported "Centriolar satellite,Cytosol" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "Centriolar satellite" "HPA019128: AB_1844682, HPA057255: AB_2683383" "unprognostic (4.07e-2)" "unprognostic (4.23e-1)" "unprognostic (1.13e-1)" "unprognostic (2.85e-2)" "unprognostic (1.03e-1)" "unprognostic (6.04e-2)" "unprognostic (2.20e-1)" "unprognostic (2.01e-2)" "unprognostic (1.84e-1)" "unprognostic (1.51e-1)" "unprognostic (1.91e-2)" "prognostic favorable (3.88e-4)" "unprognostic (3.56e-3)" "unprognostic (6.17e-4)" "unprognostic (1.18e-1)" "unprognostic (5.96e-2)" "unprognostic (6.76e-2)" 1.0 1.6 75.9 1.5 101.2 3.9 18.9 19.4 115.0 1.3 0.8 2.6 1.0 0.7 0.6 1.0 1.0 1.0 1.0 121.0 31.5 1.4 0.1 0.4 2.3 27.2 30.2 0.5 1.6 0.7 3.4 1.2 25.6 2.3 1.0 3.0 3.0 2.1 0.3 2.0 1.0 0.8 31.0 2.1 2.4 9.4 31.7 0.8 1.1 0.8 1.5 0.7 0.7 81.1 0.2 3.6 2.9 0.1 34.8 93.7 1.2 67.8 14.4 10.8 4.6 0.5 1.7 0.6 0.5 77.5 4.4 0.4 0.2 0.0 5.5 2.6 0.7 0.5 1.2 0.4 1.8 0.6 0.2 11.6 0.5 2.1 4.3 37.9 31.5 0.3 0.9 0.7 189.9 0.7 0.0 0.6 3.9 18.4 24.5 1.7 7.1 1.6 29.3 1.1 15.3 3.5 0.2 0.2 4.4 0.3 0.3 0.5 7.9 26.1 58.4 1.6 2.2 15.2 14.7 0.3 5.2 3.5 9.8 1.2 0.8 0.1 3.8 0.2 0.5 0.9 3.6 1.9 13.6 0.9 16.3 9.1 0.6 0.2 0.2 1.5 1.7 2.3 75.9 101.2 19.4 115.0 121.0 31.5 27.2 30.2 25.6 31.0 31.7 81.1 0.7 0.0 0.0 10.7 0.4 0.3 0.4 0.0 1.2 1.3 54.0 27.3 1.1 0.0 0.0 1.8 0.0 1.9 5.6 0.3 7.9 0.3 150.5 1.1 0.1 1.3 12.0 0.8 403.7 0.6 56.3 1.5 1.1 1.7 0.0 0.0 0.4 0.0 2.4 13.5 167.3 0.3 0.0 0.0 0.6 29.2 1.2 0.4 3.6 41.2 1.9 0.0 47.4 60.8 706.6 0.1 1.1 0.7 0.1 2.9 0.0 7.8 0.0 0.3 0.0 1.2 6.3 10.2 91.0 0.0 0.3 2.9 4.2 0.1 0.2 0.1 AK9 "AKD1, AKD2, C6orf199, C6orf224, dJ70A9.1, FLJ25791, FLJ42177, MGC26954" ENSG00000155085 "Adenylate kinase 9" Q5TCS8 6 109492856-109691217 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Nucleotide metabolism" "Kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 76.3;Respiratory ciliated cells: 152.0;Spermatocytes: 174.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Not detected" "Not detected" "Region enhanced" "Detected in some" "midbrain: 3.6" "HPA030804, HPA030805, HPA031779, HPA031781, HPA036324, HPA036711" Enhanced Enhanced "Nucleoplasm,Nuclear membrane" NA NA "Cluster 37: B-cells - Transcription" "Cluster 77: Retina - Visual perception" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 49: Ciliated cells - Cilium organization" "Nucleoplasm, Nuclear membrane" "HPA030804: AB_2673617, HPA030805: AB_2673618, HPA031779: AB_10603674, HPA031781: AB_2674044, HPA036324: AB_2675060, HPA036711: AB_2675265" "unprognostic (9.68e-3)" "unprognostic (2.15e-1)" "unprognostic (1.66e-2)" "unprognostic (2.36e-2)" "unprognostic (3.42e-1)" "unprognostic (7.28e-2)" "unprognostic (1.41e-3)" "unprognostic (6.76e-3)" "unprognostic (1.89e-1)" "unprognostic (3.50e-2)" "unprognostic (1.67e-4)" "unprognostic (2.58e-1)" "unprognostic (2.98e-2)" "unprognostic (1.24e-1)" "unprognostic (1.30e-1)" "unprognostic (8.39e-2)" "unprognostic (5.56e-2)" 3.5 3.1 8.1 3.3 9.9 3.7 4.8 13.5 17.2 3.5 10.9 4.6 3.6 4.3 7.6 4.3 7.9 3.5 4.9 6.4 11.0 5.3 3.1 4.1 4.2 8.8 10.7 3.6 3.4 9.2 7.7 3.1 9.5 3.9 4.5 14.1 5.1 3.9 4.8 3.9 3.6 3.9 10.7 4.0 4.5 16.6 8.7 7.6 6.9 3.5 3.6 3.4 3.2 13.4 2.3 1.6 6.6 11.5 6.1 3.7 4.8 3.5 4.3 3.6 4.9 2.6 4.6 4.9 1.7 3.4 7.9 3.7 1.9 3.9 7.6 10.2 4.0 3.8 3.8 2.6 4.8 4.4 2.3 3.1 7.3 6.6 8.6 8.8 4.2 7.2 3.6 4.0 2.7 4.7 4.1 3.2 1.5 5.1 2.5 5.5 3.7 4.7 5.0 4.3 7.8 6.4 4.2 3.9 5.9 3.7 5.1 5.8 5.2 3.1 2.2 5.1 2.3 2.0 1.8 2.8 6.8 5.9 2.0 17.1 2.8 7.1 5.1 1.5 4.4 13.1 4.9 6.2 2.1 10.8 6.2 5.4 5.6 5.6 4.8 3.1 3.9 1.6 8.1 9.9 13.5 17.2 6.4 11.0 8.8 10.7 9.5 10.7 8.7 13.4 13.3 28.9 17.2 21.2 13.6 2.7 7.7 14.7 3.4 18.3 10.4 6.7 18.9 5.7 19.9 9.2 14.6 3.4 8.6 13.1 0.0 9.1 70.9 76.3 5.4 10.0 19.8 4.2 34.8 4.5 1.5 6.0 12.2 7.3 22.1 10.6 8.9 2.1 3.6 20.2 37.0 15.5 14.2 5.3 3.9 41.7 7.5 5.6 5.4 25.3 5.0 12.6 18.6 22.6 46.9 7.4 8.9 6.4 5.5 5.6 22.9 6.8 152.0 50.7 26.3 9.1 6.9 174.3 34.1 4.0 2.6 5.6 10.3 4.7 11.4 7.9 ATRIP "FLJ12343, MGC20625, MGC21482, MGC26740" ENSG00000164053 "ATR interacting protein" Q8WXE1 3 48446710-48467645 "Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 14.9" "Low cell type specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033109, HPA047590" Approved Supported Nucleoplasm NA NA "Cluster 20: T-cells - T-cell receptor" "Cluster 23: Testis - Cell cycle regulation" "Cluster 20: HeLa - Mitochondria" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "CAB033109: AB_634993, HPA047590: AB_2680094" "unprognostic (5.43e-3)" "unprognostic (1.29e-1)" "unprognostic (2.85e-1)" "unprognostic (8.87e-2)" "unprognostic (2.34e-1)" "unprognostic (4.79e-3)" "unprognostic (4.72e-2)" "unprognostic (8.88e-3)" "unprognostic (2.66e-1)" "unprognostic (7.94e-2)" "unprognostic (2.53e-2)" "unprognostic (7.05e-2)" "unprognostic (2.01e-1)" "unprognostic (8.89e-2)" "unprognostic (2.59e-1)" "unprognostic (1.40e-2)" "unprognostic (8.52e-2)" 3.8 2.6 2.0 3.7 2.1 5.0 3.8 3.9 2.3 3.9 2.2 3.1 2.4 3.4 1.4 3.7 3.0 2.0 2.4 2.0 1.7 3.1 2.5 3.6 3.6 2.0 1.9 3.6 2.7 4.0 1.8 3.2 1.9 3.0 3.5 2.7 2.5 3.6 4.7 4.4 2.6 3.0 1.6 3.0 2.8 14.9 2.0 4.9 5.4 3.0 4.9 3.3 3.5 2.3 8.7 3.7 9.7 7.4 5.6 9.5 10.2 13.1 6.0 15.7 12.8 5.1 6.3 19.3 5.9 5.4 7.3 9.2 10.9 10.2 15.1 11.5 5.6 14.9 19.1 3.7 3.2 15.0 9.7 3.8 3.1 8.5 4.0 3.5 7.0 7.1 12.0 9.6 14.7 4.9 12.6 5.4 7.5 4.4 10.5 8.5 8.7 13.7 5.3 4.3 4.7 6.9 10.4 10.5 3.9 8.5 8.8 5.7 8.1 10.7 7.0 13.0 15.3 11.6 20.0 13.6 5.7 11.2 6.0 0.2 0.7 0.0 1.1 0.3 0.1 0.3 0.9 0.5 0.5 0.2 0.7 1.0 0.5 0.5 0.6 1.1 1.2 0.7 2.0 2.1 3.9 2.3 2.0 1.7 2.0 1.9 1.9 1.6 2.0 2.3 4.3 0.0 1.5 2.0 0.9 2.9 0.0 0.9 0.0 1.0 4.1 4.7 1.6 0.0 2.0 0.0 2.1 0.2 4.4 2.4 0.0 3.6 0.0 3.8 6.4 2.3 0.0 0.4 3.2 3.9 0.1 2.2 1.5 5.8 0.0 5.5 0.0 0.0 0.1 1.7 3.2 1.7 2.0 0.0 0.5 0.0 0.0 2.5 0.0 1.9 1.6 0.5 3.1 2.0 3.3 4.1 1.1 0.0 0.7 0.0 0.0 2.1 3.6 2.1 0.0 0.0 4.5 0.0 0.0 0.0 3.8 0.1 2.2 4.2 1.3 0.0 CANT1 "SCAN-1, SHAPY" ENSG00000171302 "Calcium activated nucleotidase 1" Q8WVQ1 17 78991716-79009867 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" Hydrolase "Cancer-related genes, Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 139.5;Intestinal goblet cells: 155.6;Syncytiotrophoblasts: 101.5;Undifferentiated cells: 100.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "OE19: 445.4;T-47d: 282.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019627, HPA019639, HPA022818" Enhanced Supported "Golgi apparatus" NA Yes 3300000 "Cluster 52: Eosinophils - Transcription" "Cluster 37: Intestine - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 27: Mucus-secreting cells - Mucin production" "Golgi apparatus" "HPA019627: AB_1845969, HPA019639: AB_1845970, HPA022818: AB_1845971" "unprognostic (1.98e-2)" "unprognostic (2.49e-2)" "unprognostic (1.50e-2)" "unprognostic (5.36e-2)" "unprognostic (2.13e-2)" "unprognostic (2.21e-2)" "prognostic unfavorable (1.41e-4)" "prognostic unfavorable (2.90e-4)" "unprognostic (1.76e-1)" "unprognostic (9.00e-2)" "unprognostic (3.30e-1)" "unprognostic (2.49e-1)" "prognostic unfavorable (6.21e-4)" "unprognostic (7.04e-2)" "unprognostic (5.06e-2)" "unprognostic (1.16e-1)" "unprognostic (7.23e-2)" 15.8 23.9 10.4 24.7 12.4 19.1 25.4 13.6 11.3 32.3 13.8 89.2 51.9 17.4 8.7 44.8 18.2 25.2 17.0 11.1 12.6 16.1 17.3 16.4 15.2 14.6 14.5 14.6 19.6 24.5 17.5 25.9 13.9 71.8 82.8 7.4 62.7 32.4 14.9 14.9 55.5 15.5 13.8 26.5 51.1 20.7 14.5 14.7 13.9 12.4 15.1 16.7 21.7 17.8 106.5 112.1 31.9 46.3 29.7 35.2 38.9 66.0 51.3 66.7 55.9 53.8 99.6 25.3 36.1 46.1 83.0 53.7 27.1 49.8 68.4 43.0 46.4 33.7 34.1 45.9 25.0 33.0 51.6 33.7 32.4 62.7 34.2 40.9 116.1 42.5 42.3 43.2 46.4 58.4 50.2 19.8 22.1 445.4 103.1 27.6 51.8 29.8 29.8 53.5 45.6 45.4 33.9 227.2 50.2 50.3 282.6 38.6 56.6 101.9 90.5 46.4 83.1 48.9 43.8 24.3 64.4 24.9 65.3 6.3 4.0 8.7 5.5 4.4 5.7 3.9 4.3 4.8 3.8 2.5 4.1 4.1 17.4 3.1 3.0 2.7 3.6 4.6 10.4 12.4 13.6 11.3 11.1 12.6 14.6 14.5 13.9 13.8 14.5 17.8 12.6 28.9 20.6 5.9 11.8 16.6 15.3 16.8 6.8 6.4 49.9 16.3 13.3 14.3 15.1 12.9 14.6 36.6 8.9 139.5 3.9 34.7 14.0 10.7 13.1 16.3 51.0 15.2 4.1 28.8 39.4 13.5 38.2 19.0 5.7 20.0 41.7 14.4 24.9 5.0 5.2 155.6 16.2 12.4 9.5 15.7 11.8 14.2 14.2 3.7 18.1 8.1 11.3 5.0 10.2 37.7 55.8 7.5 16.6 33.4 39.4 6.7 9.7 8.7 6.6 9.5 13.3 23.9 5.8 12.0 13.1 101.5 11.1 11.3 100.2 19.4 CMPK1 "CMPK, UMP-CMPK" ENSG00000162368 "Cytidine/uridine monophosphate kinase 1" P30085 1 47333797-47378839 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Pyrimidine biosynthesis" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA053730, HPA058604" Approved Supported Nucleoplasm "Intracellular and membrane" NA NA 1400000 "Cluster 34: Basophils - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 44: HDLM-2 - Immune response" "Cluster 27: Mucus-secreting cells - Mucin production" Nucleoplasm "HPA053730: AB_2682244, HPA058604: AB_2683773" "unprognostic (2.16e-2)" "unprognostic (1.16e-1)" "unprognostic (9.39e-3)" "unprognostic (1.18e-1)" "unprognostic (1.09e-3)" "unprognostic (1.50e-2)" "unprognostic (1.59e-2)" "unprognostic (9.88e-2)" "unprognostic (5.80e-2)" "unprognostic (2.90e-2)" "unprognostic (1.71e-2)" "unprognostic (2.61e-1)" "unprognostic (1.28e-2)" "unprognostic (2.58e-2)" "unprognostic (1.06e-1)" "unprognostic (1.02e-3)" "unprognostic (7.36e-2)" 88.2 45.2 47.0 64.2 50.6 53.1 102.2 51.9 73.1 74.8 49.8 134.1 163.9 44.2 42.2 108.2 35.2 88.5 63.3 44.5 56.9 78.7 217.2 63.8 71.8 52.6 52.4 38.1 90.9 57.7 32.9 48.8 54.2 95.0 141.0 29.2 157.4 50.7 71.1 65.1 152.5 56.0 52.6 58.0 109.0 17.5 52.3 61.7 92.0 73.9 87.9 80.6 63.8 55.3 124.9 68.4 86.6 77.9 154.6 179.3 122.5 216.4 129.8 128.6 129.9 61.3 84.1 183.4 108.6 147.9 120.5 82.7 64.8 112.1 174.9 279.5 52.7 142.9 91.0 106.7 100.8 206.2 100.2 101.2 132.7 107.5 119.7 121.1 135.2 67.4 137.3 143.5 169.8 45.9 168.2 96.8 55.1 162.9 93.6 103.4 149.8 138.5 126.5 134.9 78.3 41.3 155.0 177.7 128.9 113.7 44.2 121.0 127.7 159.6 92.7 154.5 180.8 103.8 154.3 124.4 126.3 125.3 111.7 43.3 12.8 24.2 16.1 14.0 20.7 13.6 18.0 20.0 13.5 14.3 16.9 16.4 5.3 19.4 17.0 11.4 20.9 15.6 47.0 50.6 51.9 73.1 44.5 56.9 52.6 52.4 54.2 52.6 52.3 55.3 101.7 70.5 54.4 14.4 148.1 175.5 125.3 88.9 102.4 34.2 167.8 67.7 48.9 147.3 87.0 75.4 16.7 82.3 117.9 280.0 174.1 186.8 1.6 56.2 63.3 83.8 117.5 126.0 28.5 181.6 133.0 91.2 125.4 98.2 94.0 39.7 88.5 235.9 75.9 43.7 30.2 326.6 91.6 122.0 265.0 5.0 59.4 107.1 254.3 31.9 100.5 66.9 124.6 20.6 25.0 146.8 168.6 70.0 119.8 203.5 234.6 254.5 112.3 31.1 85.5 75.9 95.8 14.0 29.8 167.0 195.1 118.3 160.5 49.0 240.2 250.8 CMPK2 "NDK, TYKi, UMP-CMPK2" ENSG00000134326 "Cytidine/uridine monophosphate kinase 2" Q5EBM0 2 6840570-6866635 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Pyrimidine biosynthesis" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 10.6;salivary gland: 8.5" "Cell type enriched" "Detected in many" 4 "Erythroid cells: 86.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "eosinophil: 4.9" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "BJ hTERT+ SV40 Large T+: 12.8;BJ hTERT+ SV40 Large T+ RasG12V: 11.9;HEL: 20.3;MOLT-4: 11.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041430 Approved Supported Nucleoplasm,Mitochondria NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 36: HEL - Hemostasis" "Cluster 6: Erythroid cells - Oxygen transport" Mitochondria Nucleoplasm "HPA041430: AB_10796674" "unprognostic (2.37e-1)" "unprognostic (6.07e-2)" "unprognostic (5.71e-2)" "prognostic unfavorable (4.71e-4)" "unprognostic (1.82e-1)" "unprognostic (5.08e-2)" "unprognostic (3.80e-2)" "unprognostic (8.93e-2)" "unprognostic (6.63e-2)" "unprognostic (4.54e-3)" "unprognostic (7.39e-3)" "unprognostic (1.43e-1)" "unprognostic (1.09e-3)" "unprognostic (1.28e-1)" "unprognostic (1.77e-2)" "unprognostic (7.69e-2)" "unprognostic (4.32e-2)" 2.1 1.4 1.7 1.4 2.8 6.4 1.8 0.7 1.8 1.4 1.7 1.3 1.6 0.9 0.3 0.7 0.7 0.8 2.1 1.2 1.9 1.1 0.9 2.8 1.3 6.0 3.0 0.4 1.3 0.9 1.1 1.6 3.2 0.7 0.6 0.1 8.5 0.7 1.1 0.4 2.2 0.9 10.6 3.5 2.9 2.0 2.0 1.9 1.2 1.6 0.7 0.9 0.6 1.5 0.3 0.0 0.1 0.0 0.0 0.0 2.5 0.0 0.2 12.8 11.9 0.0 1.4 3.1 0.8 0.0 3.3 0.2 0.0 0.0 0.0 0.3 0.2 20.3 0.0 0.0 0.0 0.6 1.8 0.1 0.0 0.2 0.0 0.0 0.0 2.0 5.8 0.1 0.0 0.1 11.8 3.6 0.3 0.0 1.0 3.6 0.0 0.0 0.0 0.4 0.4 0.5 0.2 0.0 1.9 0.0 0.0 1.3 0.0 0.0 0.2 0.0 0.0 3.3 0.4 0.0 0.0 3.6 0.8 3.1 1.6 4.9 0.3 3.9 0.2 1.1 0.2 0.2 1.1 0.1 0.2 0.3 1.1 0.5 2.0 0.1 0.4 0.7 1.7 2.8 0.7 1.8 1.2 1.9 6.0 3.0 3.2 10.6 2.0 1.5 20.8 3.2 7.5 0.0 1.9 0.4 0.9 0.5 0.0 1.5 1.7 1.3 1.6 0.0 0.5 1.8 0.0 3.0 3.4 10.0 1.9 2.6 4.0 5.4 0.8 11.7 7.2 86.3 1.9 6.6 2.9 2.7 11.2 1.0 2.5 1.7 7.1 1.4 19.5 0.0 2.5 2.5 0.0 12.3 2.8 1.6 1.5 11.3 0.0 9.4 11.9 5.3 3.1 1.5 0.2 6.2 8.4 5.7 2.1 1.0 8.4 0.7 4.1 0.2 0.0 2.2 2.0 2.7 4.4 0.7 0.4 0.8 4.5 1.6 1.6 2.0 DCK ENSG00000156136 "Deoxycytidine kinase" P27707 4 70992538-71030914 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 105.8" "Cell type enhanced" "Detected in many" "B-cells: 105.7;Erythroid cells: 284.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Daudi: 232.9;U-698: 191.8" "Low region specificity" "Detected in all" "HPA059609, HPA062773" Enhanced Supported Nucleoplasm NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 3: T-cells - Adaptive immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 6: Erythroid cells - Oxygen transport" Nucleoplasm "HPA059609: AB_2684082, HPA062773: AB_2684865" "unprognostic (9.16e-2)" "unprognostic (2.44e-1)" "unprognostic (5.24e-3)" "unprognostic (4.77e-2)" "unprognostic (3.95e-1)" "unprognostic (6.45e-2)" "prognostic unfavorable (6.90e-7)" "unprognostic (3.04e-2)" "unprognostic (7.19e-2)" "unprognostic (8.28e-2)" "unprognostic (4.51e-1)" "unprognostic (1.33e-1)" "unprognostic (3.37e-2)" "unprognostic (4.47e-2)" "unprognostic (6.82e-2)" "unprognostic (1.33e-1)" "unprognostic (2.27e-2)" 11.1 15.2 10.1 36.3 11.2 43.9 12.5 9.7 13.6 9.9 11.0 15.7 13.7 13.4 7.2 14.6 9.8 12.4 10.4 10.7 10.7 9.8 9.2 13.4 92.9 10.9 10.4 10.6 8.3 8.8 3.5 15.3 10.8 10.2 18.9 17.1 7.7 7.1 9.5 14.7 15.9 13.9 11.4 32.3 14.2 9.0 9.7 105.8 15.7 12.1 79.6 14.2 6.1 13.4 25.8 17.2 38.5 23.9 12.4 20.4 21.0 65.3 25.6 53.3 43.6 11.3 56.1 232.9 24.7 28.3 31.0 14.8 34.6 21.4 71.0 43.5 16.2 46.6 18.6 20.5 11.8 95.8 58.5 11.2 25.5 32.2 19.5 26.0 31.0 64.4 19.0 93.2 62.0 15.5 126.6 39.5 17.2 45.6 15.6 96.0 74.0 18.6 26.6 18.8 35.1 31.8 24.9 49.6 29.7 17.4 22.3 54.3 22.0 60.1 41.8 47.6 37.1 31.7 21.2 191.8 40.7 60.0 45.0 25.6 17.2 28.9 24.2 20.5 32.0 44.5 33.0 30.6 23.8 41.1 34.2 34.2 8.1 34.4 21.0 63.6 41.2 45.1 10.1 11.2 9.7 13.6 10.7 10.7 10.9 10.4 10.8 11.4 9.7 13.4 16.4 0.0 8.6 6.8 105.7 43.0 10.1 11.9 27.9 16.1 10.4 5.2 6.5 7.2 7.5 12.9 6.2 11.9 97.7 10.4 29.4 19.2 0.7 5.9 7.0 16.3 21.0 284.8 17.1 6.2 19.3 11.0 8.6 7.4 22.9 7.5 22.9 7.2 38.2 18.5 21.0 16.4 22.4 63.2 74.5 2.3 8.4 56.0 46.2 18.7 61.4 15.8 84.5 8.0 11.1 10.5 8.0 10.1 24.6 11.6 7.1 10.0 4.7 10.7 6.6 9.3 15.9 52.0 33.9 28.0 43.3 4.5 62.4 4.8 16.5 8.4 DCTD ENSG00000129187 "DCMP deaminase" P32321 4 182890060-182917936 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Nucleotide biosynthesis" "Allosteric enzyme, Hydrolase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA035894 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 18: Non-specific - Mitochondria" "Cluster 2: Karpas-707 - Immune response" "Cluster 16: Pancreatic endocrine cells - Mixed function" "Nucleoplasm, Cytosol" "HPA035894: AB_10673488" "unprognostic (1.26e-1)" "unprognostic (9.80e-3)" "unprognostic (3.15e-2)" "unprognostic (3.78e-3)" "unprognostic (3.13e-3)" "unprognostic (2.20e-2)" "unprognostic (2.01e-2)" "unprognostic (4.59e-3)" "unprognostic (2.62e-2)" "unprognostic (1.80e-1)" "unprognostic (1.40e-2)" "unprognostic (1.20e-1)" "prognostic favorable (1.81e-4)" "unprognostic (1.35e-1)" "unprognostic (1.59e-1)" "unprognostic (3.89e-2)" "unprognostic (1.12e-1)" 50.8 83.8 39.0 41.6 40.3 29.5 46.7 40.1 44.8 48.9 51.1 41.4 33.1 47.8 29.7 61.2 49.0 54.7 40.6 39.8 43.6 48.9 79.8 41.2 45.2 43.0 42.8 65.8 54.9 61.8 46.9 36.7 40.2 39.9 40.9 25.1 44.6 41.7 41.7 39.3 36.3 46.4 43.8 50.3 54.1 21.8 42.6 42.2 100.8 32.9 49.6 50.1 45.6 46.0 97.8 87.4 88.4 81.3 129.6 176.7 115.0 184.1 163.0 128.7 79.7 89.2 183.0 33.5 44.3 179.9 87.1 47.3 65.5 114.9 117.1 163.8 50.4 155.9 50.4 109.1 139.5 153.3 93.3 149.8 120.8 113.6 117.8 129.6 112.2 73.1 157.4 324.5 175.6 71.5 100.1 94.7 70.0 39.8 79.3 107.3 62.2 65.8 107.9 115.1 86.7 54.3 86.7 73.8 87.4 81.2 56.7 78.8 131.7 105.7 81.7 52.0 142.0 124.5 72.9 42.8 117.4 98.5 127.1 68.6 47.9 45.2 61.0 58.8 76.8 71.0 52.6 62.7 55.0 48.6 51.6 54.6 3.3 73.7 60.2 42.4 50.6 55.6 39.0 40.3 40.1 44.8 39.8 43.6 43.0 42.8 40.2 43.8 42.6 46.0 31.6 12.8 19.5 8.8 31.7 25.4 34.4 35.4 37.5 4.9 39.4 34.2 24.3 38.6 21.5 33.1 4.2 19.0 26.6 16.8 37.2 68.8 7.0 19.7 41.6 30.9 14.5 27.1 10.7 54.5 26.8 42.3 15.8 22.3 22.8 36.2 30.0 45.2 53.8 3.3 11.7 28.5 18.3 38.8 32.1 18.0 44.1 29.4 26.6 9.4 34.8 37.4 25.7 3.0 3.1 75.5 18.5 35.3 27.6 46.1 19.3 45.8 18.7 5.5 32.9 25.8 34.6 10.2 15.4 54.5 23.0 7.3 27.6 42.4 31.3 42.3 DCTPP1 "CDA03, MGC5627, RS21C6, XTP3TPA" ENSG00000179958 "DCTP pyrophosphatase 1" Q9H773 16 30423615-30430030 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002832 Uncertain Supported Nucleoplasm,Cytosol NA Yes 61000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 8: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Cytosol" "HPA002832: AB_1080615" "prognostic unfavorable (1.64e-5)" "unprognostic (1.61e-1)" "unprognostic (1.99e-3)" "unprognostic (1.17e-2)" "unprognostic (1.36e-1)" "unprognostic (4.09e-2)" "prognostic unfavorable (6.28e-4)" "unprognostic (2.23e-1)" "unprognostic (1.07e-1)" "unprognostic (4.35e-2)" "unprognostic (2.43e-2)" "unprognostic (3.65e-2)" "prognostic favorable (9.71e-9)" "unprognostic (1.10e-3)" "unprognostic (8.78e-3)" "unprognostic (1.10e-2)" "unprognostic (2.53e-1)" 21.0 21.4 17.6 27.4 18.4 22.2 30.5 18.7 22.5 18.6 18.9 56.4 32.0 18.6 20.0 28.3 28.1 19.5 31.1 18.4 19.5 39.7 21.8 16.2 35.5 18.1 17.6 14.0 24.9 32.1 10.3 16.0 19.0 21.8 58.4 12.2 25.5 19.3 44.7 25.1 27.7 20.5 18.4 27.8 24.3 9.1 18.1 24.5 20.1 36.9 35.7 27.0 19.1 19.4 124.7 149.8 66.8 85.8 18.4 24.1 61.9 58.4 35.1 87.4 87.9 114.7 103.4 168.1 119.1 36.8 54.9 95.9 141.4 115.1 103.5 89.2 221.0 98.3 61.5 150.3 24.1 177.0 144.2 28.6 64.8 96.4 55.6 25.4 88.7 88.2 125.8 57.4 61.5 217.8 210.0 189.9 88.8 124.2 119.2 293.1 74.8 218.1 98.9 80.2 141.4 80.4 39.0 137.7 55.3 41.5 118.4 73.9 45.9 66.0 59.1 85.8 107.2 36.9 118.4 217.5 43.8 145.7 79.6 70.6 36.7 38.1 54.0 70.0 75.8 146.7 68.4 61.4 86.7 128.7 60.9 59.0 4.6 76.1 79.2 94.6 76.4 81.0 17.6 18.4 18.7 22.5 18.4 19.5 18.1 17.6 19.0 18.4 18.1 19.4 34.0 19.2 15.2 0.7 38.2 90.2 53.3 92.5 33.6 23.3 45.8 48.9 34.8 51.5 37.9 44.1 8.4 103.2 22.7 130.3 127.2 135.6 13.4 32.6 29.9 47.4 38.5 29.6 2.6 124.8 101.0 28.3 27.5 66.5 31.1 40.2 31.1 23.2 76.9 15.2 2.7 142.3 73.2 21.0 49.1 45.1 19.6 26.9 48.0 1.0 73.2 25.0 23.7 2.5 4.4 89.0 115.8 19.9 24.1 86.9 68.8 76.7 27.8 21.4 19.7 23.7 40.0 3.3 44.8 39.4 80.3 27.8 28.3 53.8 168.5 45.7 DGUOK dGK ENSG00000114956 "Deoxyguanosine kinase" Q16854 2 73926826-73958961 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase" "Disease variant, Neuropathy, Primary mitochondrial disease, Progressive external ophthalmoplegia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034766, HPA057246" Approved NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "HPA034766: AB_10669850, HPA057246: AB_2683381" "unprognostic (3.40e-1)" "unprognostic (2.43e-1)" "unprognostic (1.45e-2)" "unprognostic (2.94e-2)" "unprognostic (1.20e-1)" "unprognostic (4.17e-2)" "unprognostic (2.14e-2)" "unprognostic (1.37e-2)" "unprognostic (4.10e-3)" "unprognostic (5.07e-2)" "unprognostic (1.41e-1)" "unprognostic (9.84e-2)" "prognostic unfavorable (8.69e-7)" "unprognostic (3.86e-1)" "unprognostic (2.21e-2)" "unprognostic (5.98e-2)" "prognostic favorable (7.47e-4)" 20.8 30.0 37.1 20.3 39.2 27.1 28.1 36.5 48.4 23.0 36.8 25.0 17.7 23.1 34.4 21.8 31.3 19.4 23.0 38.5 42.8 24.6 30.5 17.7 36.8 37.9 37.7 30.0 16.3 11.0 41.3 21.5 39.1 24.5 29.1 34.5 19.8 22.5 17.1 26.5 20.2 21.9 37.9 25.9 21.0 32.8 38.8 36.3 22.6 17.7 40.9 22.2 20.9 38.8 45.1 72.5 74.4 67.9 47.8 53.8 37.1 29.3 56.0 66.7 61.1 91.2 51.5 83.0 27.4 42.1 74.1 34.7 85.4 57.1 79.3 47.1 53.6 65.8 25.4 107.5 70.5 62.1 66.0 49.7 51.3 50.4 58.9 48.6 48.3 91.4 67.2 37.0 78.8 54.4 59.6 101.2 76.7 60.5 53.9 73.8 73.1 59.7 55.8 49.6 85.0 82.6 27.9 28.2 77.1 35.5 34.0 34.8 45.3 43.3 68.8 37.8 52.6 32.3 31.4 86.1 62.2 65.9 95.1 129.8 70.9 138.7 62.3 87.3 72.4 108.5 77.0 69.6 81.6 114.5 98.6 79.6 56.4 79.4 84.7 91.3 79.9 91.3 37.1 39.2 36.5 48.4 38.5 42.8 37.9 37.7 39.1 37.9 38.8 38.8 72.5 32.1 42.8 14.7 103.4 74.2 138.7 249.6 88.2 52.3 85.0 128.1 19.1 78.6 108.6 60.7 6.2 159.4 89.7 58.9 84.1 102.6 12.3 82.3 69.1 74.1 113.1 67.1 17.5 149.1 165.4 88.3 40.2 82.6 57.6 87.4 76.1 69.9 90.9 52.2 21.1 100.1 158.7 88.3 112.3 15.1 93.5 80.2 110.3 15.9 151.9 89.5 118.4 12.5 27.2 173.0 88.1 86.9 70.2 146.2 88.2 119.7 87.2 40.4 92.1 55.3 89.3 105.3 129.4 88.3 83.3 124.5 101.4 124.5 104.9 142.9 DNM1 DNM ENSG00000106976 "Dynamin 1" Q05193 9 128191655-128255248 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Endocytosis "Hydrolase, Motor protein" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "brain: 319.5" "Cell type enhanced" "Detected in many" "Bipolar cells: 112.4;Cone photoreceptor cells: 89.6;Excitatory neurons: 176.1;Inhibitory neurons: 182.2;Rod photoreceptor cells: 78.4" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in many" "cerebral cortex: 319.5" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 126.9;U-87 MG: 46.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005920, HPA049910" Enhanced NA NA 8800 "Cluster 10: Brain - Neuronal signaling" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB005920: , HPA049910: AB_2680948" "unprognostic (3.25e-2)" "unprognostic (5.49e-2)" "unprognostic (1.34e-3)" "unprognostic (3.95e-2)" "unprognostic (4.57e-2)" "unprognostic (1.16e-1)" "unprognostic (3.60e-3)" "unprognostic (1.20e-1)" "unprognostic (5.53e-2)" "unprognostic (6.53e-2)" "unprognostic (6.62e-3)" "unprognostic (6.30e-1)" "unprognostic (9.58e-2)" "unprognostic (1.10e-1)" "unprognostic (2.02e-1)" "unprognostic (3.07e-3)" "unprognostic (1.10e-3)" 22.2 7.9 99.8 3.7 129.1 2.0 13.2 13.6 319.5 30.8 0.0 8.0 1.9 8.8 2.4 5.5 9.4 13.4 7.8 140.1 15.9 14.1 5.3 4.6 2.4 50.7 4.1 2.5 8.4 4.1 33.6 2.5 36.6 9.0 2.7 68.3 9.0 3.0 3.2 15.0 9.0 5.3 0.0 1.0 5.0 4.9 10.0 0.9 5.2 4.0 1.8 10.6 21.6 123.1 8.7 126.9 11.3 2.8 3.6 36.8 0.6 8.0 18.9 15.7 6.5 1.7 2.6 0.2 10.7 16.7 0.6 15.3 1.8 0.8 8.6 0.1 12.1 8.3 19.5 0.5 2.6 1.1 5.6 9.8 0.2 12.4 0.2 15.2 0.0 7.3 3.1 0.5 0.0 3.6 0.7 2.7 12.2 2.2 23.1 15.6 0.4 3.9 2.4 0.0 16.1 27.1 27.1 0.8 1.2 1.4 0.3 11.2 0.6 0.5 34.8 36.2 16.6 1.0 0.4 0.8 46.8 0.4 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 99.8 129.1 13.6 319.5 140.1 15.9 50.7 4.1 36.6 0.0 10.0 123.1 2.2 0.0 0.0 18.9 0.9 7.9 1.7 0.3 8.0 112.4 2.9 3.9 2.0 5.7 0.8 0.0 89.6 0.3 0.2 0.4 1.9 0.8 0.9 1.3 19.0 1.8 0.0 0.0 176.1 0.9 0.4 24.3 2.6 1.4 1.3 2.8 0.7 0.6 10.6 50.5 182.2 0.9 0.0 0.6 10.5 1.0 2.8 9.2 3.6 22.5 1.3 10.7 0.0 33.7 14.3 0.6 5.0 1.5 0.7 0.8 2.5 5.3 1.1 78.4 0.0 2.1 3.8 1.0 1.8 2.5 7.5 0.8 1.6 2.1 1.6 0.8 DNM1L "DRP1, DVLP, DYMPLE, HDYNIV, VPS1" ENSG00000087470 "Dynamin 1 like" O00429 12 32679200-32745650 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Biological rhythms, Endocytosis, Necrosis" Hydrolase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009952, HPA039324" Approved Enhanced Vesicles,Cytosol NA NA 2000000 "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 5: NTERA-2 - Transcription" "Cluster 46: Photoreceptor cells - Phototransduction" Cytosol Vesicles "CAB009952: AB_2093533, HPA039324: AB_2676443" "unprognostic (2.64e-2)" "unprognostic (2.94e-1)" "unprognostic (1.10e-3)" "unprognostic (1.12e-1)" "unprognostic (5.09e-1)" "unprognostic (4.06e-2)" "prognostic unfavorable (6.27e-6)" "unprognostic (8.68e-2)" "unprognostic (2.25e-2)" "unprognostic (1.04e-2)" "unprognostic (1.71e-1)" "unprognostic (2.63e-1)" "unprognostic (4.06e-1)" "unprognostic (1.00e-1)" "unprognostic (8.17e-2)" "unprognostic (7.48e-2)" "unprognostic (1.57e-2)" 23.2 23.2 25.3 23.5 27.5 40.0 21.1 27.7 32.3 18.4 15.7 24.0 18.6 23.6 23.9 28.6 19.8 17.5 38.9 28.4 26.1 27.9 14.2 16.7 20.9 22.5 22.0 20.0 13.5 40.5 25.3 23.9 23.6 27.0 22.7 44.9 16.0 28.7 43.8 18.3 16.8 32.0 22.2 18.8 17.3 36.0 21.6 21.4 22.4 57.2 24.8 29.9 18.5 26.6 66.8 62.3 64.3 68.3 51.2 52.7 123.2 72.0 55.4 67.2 61.7 80.6 48.0 87.3 50.0 65.8 66.9 57.8 69.2 80.3 79.3 46.6 57.6 102.3 57.2 48.2 41.7 72.5 50.1 48.6 37.4 70.7 66.1 63.5 81.1 41.4 74.4 37.5 75.3 21.7 29.1 61.7 138.2 41.0 30.8 48.6 125.0 61.5 56.5 79.1 57.1 59.3 76.3 51.8 56.7 129.4 59.7 49.0 74.0 57.3 54.4 135.3 68.2 26.1 75.8 86.3 55.6 47.0 43.5 7.4 10.0 3.2 5.6 15.6 6.9 7.0 6.2 6.1 18.8 6.0 7.3 8.4 1.8 8.1 15.6 5.6 7.3 7.9 25.3 27.5 27.7 32.3 28.4 26.1 22.5 22.0 23.6 22.2 21.6 26.6 42.5 38.5 38.4 82.6 36.0 30.0 34.7 28.0 44.3 80.9 32.5 29.2 82.8 20.0 33.3 25.8 131.3 30.0 53.8 26.7 31.3 34.8 63.9 38.8 55.8 42.0 30.5 28.4 139.4 25.1 63.7 41.0 23.9 59.4 50.7 48.8 26.4 16.0 30.8 126.2 150.0 24.9 34.6 27.5 30.7 78.0 26.8 43.3 14.2 44.0 45.6 59.0 34.0 99.5 121.7 45.7 14.4 30.5 48.5 42.8 11.4 23.3 22.8 164.8 19.7 55.0 55.5 79.3 52.3 39.6 27.6 36.0 42.2 26.0 31.5 36.4 DNM2 "CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII" ENSG00000079805 "Dynamin 2" P50570 19 10718079-10833488 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Endocytosis, Phagocytosis" "Hydrolase, Motor protein" "Cancer-related genes, Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 242.8;Paneth cells: 177.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054246 Supported Approved "Golgi apparatus,Cytosol" NA NA 230000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Golgi apparatus, Cytosol" "HPA054246: AB_2682427" "unprognostic (2.30e-1)" "unprognostic (5.23e-2)" "unprognostic (4.72e-2)" "unprognostic (1.23e-1)" "unprognostic (1.76e-1)" "prognostic favorable (8.91e-4)" "prognostic unfavorable (3.63e-4)" "unprognostic (1.03e-1)" "unprognostic (3.79e-1)" "unprognostic (1.89e-1)" "unprognostic (4.75e-2)" "unprognostic (5.35e-2)" "unprognostic (5.47e-2)" "unprognostic (5.40e-3)" "unprognostic (2.68e-1)" "unprognostic (1.61e-1)" "unprognostic (1.99e-3)" 55.1 69.9 50.5 63.2 77.8 125.7 46.1 74.1 64.1 49.0 38.8 105.8 65.9 42.2 25.3 67.6 42.5 40.5 87.2 52.3 57.4 72.8 57.2 87.0 62.4 82.7 78.9 36.6 68.2 38.9 41.9 51.3 79.8 47.4 83.9 30.7 55.0 55.7 108.1 92.8 99.6 35.1 60.3 81.0 98.6 55.1 72.9 58.6 47.6 82.8 65.4 64.6 54.5 101.6 116.4 92.8 67.6 54.6 67.6 65.4 86.5 75.1 70.5 108.8 91.7 94.2 74.7 83.2 132.2 81.5 52.5 99.4 92.6 82.1 90.8 103.1 72.4 160.1 81.7 107.1 82.9 87.8 146.5 67.8 62.4 83.5 77.9 66.2 107.3 84.9 131.5 139.1 68.0 140.1 126.3 85.7 76.6 138.3 109.7 125.6 72.6 95.7 71.3 171.1 97.1 63.8 86.6 73.6 54.2 74.9 58.8 106.2 99.6 120.7 40.5 172.0 102.7 112.7 127.3 77.9 89.9 134.0 61.0 3.5 3.5 7.0 4.0 6.2 3.8 2.5 3.0 4.4 4.2 2.1 1.7 3.0 6.5 8.9 8.4 8.4 3.8 4.1 50.5 77.8 74.1 64.1 52.3 57.4 82.7 78.9 79.8 60.3 72.9 101.6 37.8 32.1 22.3 24.8 48.8 23.2 17.1 13.8 22.2 28.8 19.7 16.3 30.3 14.3 25.7 51.5 22.9 25.7 57.2 242.8 50.9 35.2 48.4 32.2 17.9 33.1 21.6 38.1 29.2 32.0 106.9 19.5 168.7 39.7 19.0 36.8 20.3 22.8 49.1 43.7 31.1 106.9 14.2 28.0 39.6 98.0 16.8 55.2 19.6 60.9 43.4 17.2 39.1 23.1 90.9 45.2 177.3 27.8 92.2 20.2 90.7 38.8 18.0 26.3 26.3 18.7 27.6 15.0 12.3 26.6 31.5 31.7 46.4 40.7 82.5 22.8 DNM3 KIAA0820 ENSG00000197959 "Dynamin 3" Q9UQ16 1 171841498-172418466 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Endocytosis "Hydrolase, Motor protein" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "brain: 66.9" "Cell type enhanced" "Detected in many" "Excitatory neurons: 365.7;Inhibitory neurons: 631.8;Oligodendrocyte precursor cells: 976.1;Oligodendrocytes: 1970.9" "Cancer enhanced" "Detected in many" "glioma: 2.0" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "T-reg: 1.4" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "HEL: 22.9;HMC-1: 10.2;RPTEC TERT1: 19.0;U-251 MG: 14.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA064121 Approved "Golgi apparatus" NA NA 70000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 70: Brain - Nervous system development" "Cluster 3: HMC-1 - Innate immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Golgi apparatus" "HPA064121: AB_2685193" "unprognostic (8.21e-2)" "unprognostic (6.80e-3)" "unprognostic (1.68e-1)" "unprognostic (1.41e-2)" "unprognostic (8.84e-2)" "unprognostic (2.07e-1)" "unprognostic (9.52e-3)" "unprognostic (6.46e-2)" "unprognostic (5.52e-2)" "unprognostic (2.96e-2)" "unprognostic (2.45e-2)" "unprognostic (3.37e-1)" "unprognostic (6.10e-4)" "unprognostic (1.60e-3)" "unprognostic (1.35e-1)" "unprognostic (2.22e-1)" "unprognostic (2.70e-3)" 4.2 11.9 15.3 1.0 29.9 1.3 4.0 59.4 24.3 5.8 0.0 2.4 0.6 3.2 1.3 1.3 3.2 2.7 2.1 12.2 36.0 4.1 0.4 4.4 1.1 42.8 29.5 2.6 1.1 1.2 6.2 0.4 47.8 2.6 1.1 13.4 2.1 1.6 1.2 2.4 1.4 3.1 10.6 1.8 2.7 3.2 32.3 1.8 3.3 1.3 0.8 2.2 5.1 66.9 0.8 2.5 2.0 0.4 1.5 1.0 0.0 0.5 1.2 1.0 1.3 0.0 3.7 0.0 7.5 1.1 1.2 0.3 1.5 2.9 0.9 1.0 2.9 22.9 3.7 0.0 0.1 0.5 10.2 0.7 0.5 1.2 0.7 1.1 0.5 2.0 0.0 0.3 0.4 0.0 1.5 0.1 5.8 9.5 1.7 1.5 9.9 0.0 19.0 0.1 3.9 0.8 2.7 0.7 0.2 0.7 0.0 0.9 0.3 2.8 3.8 2.3 14.3 3.8 0.7 0.2 2.7 1.2 1.0 0.0 0.1 0.0 0.2 0.0 0.3 0.2 0.3 0.1 0.2 0.0 0.3 0.5 0.3 0.3 0.1 0.0 1.4 1.2 15.3 29.9 59.4 24.3 12.2 36.0 42.8 29.5 47.8 10.6 32.3 66.9 21.8 0.0 6.8 207.3 1.5 2.4 1.5 0.7 3.4 25.1 1.4 1.3 2.4 0.0 0.4 0.0 29.2 0.1 0.7 0.2 3.9 0.3 8.2 7.3 1.3 19.5 0.0 0.8 365.7 0.4 0.1 3.2 7.1 1.0 1.3 0.8 8.2 0.2 0.7 8.4 631.8 0.7 0.0 0.6 3.1 3.9 1.8 13.4 0.0 178.0 0.3 5.9 0.0 976.1 1970.9 2.5 0.1 2.6 0.3 0.7 0.0 0.8 2.2 29.0 0.0 4.5 2.2 5.3 0.4 1.1 1.7 0.3 0.9 10.3 0.8 0.7 DTYMK "CDC8, TMPK, TYMK" ENSG00000168393 "Deoxythymidylate kinase" P23919 2 241675747-241686944 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Nucleotide biosynthesis" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Erythroid cells: 108.6;Extravillous trophoblasts: 149.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042593, HPA042719" Approved Approved Mitochondria NA NA 7000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Mitochondria "HPA042593: AB_10959590, HPA042719: AB_10960633" "unprognostic (1.90e-1)" "unprognostic (6.95e-2)" "unprognostic (4.14e-1)" "unprognostic (8.61e-2)" "unprognostic (1.89e-1)" "unprognostic (9.45e-2)" "prognostic unfavorable (1.73e-5)" "unprognostic (1.44e-2)" "unprognostic (2.64e-2)" "unprognostic (5.50e-2)" "unprognostic (2.60e-2)" "unprognostic (6.94e-2)" "prognostic unfavorable (1.22e-4)" "unprognostic (7.13e-2)" "unprognostic (6.81e-2)" "unprognostic (5.07e-2)" "unprognostic (9.19e-2)" 12.2 16.0 15.6 15.6 17.1 37.0 11.8 16.2 19.8 11.2 16.5 15.1 13.2 10.8 6.1 19.1 10.2 8.6 10.6 14.5 15.0 14.9 18.8 9.7 24.8 16.8 16.0 8.2 9.5 7.5 5.0 11.1 16.1 11.1 12.2 4.3 9.8 7.4 8.1 18.8 14.0 13.4 15.3 17.2 13.3 8.2 16.8 24.1 8.7 6.4 19.2 10.6 11.2 17.2 102.6 112.3 93.6 120.1 30.2 33.3 103.2 82.1 63.2 110.8 125.6 54.8 120.1 48.3 24.6 66.8 126.8 84.4 87.8 102.2 56.7 118.8 104.6 103.9 88.3 105.1 26.3 69.1 83.1 23.7 27.3 102.7 42.4 32.1 104.8 74.4 123.6 38.4 114.1 112.6 132.2 125.0 100.7 113.1 94.2 111.4 139.8 71.8 62.3 59.5 115.0 74.0 53.4 81.5 67.9 27.0 74.2 120.0 66.5 147.5 110.4 99.0 152.5 47.3 49.1 144.6 122.4 112.2 184.9 20.5 26.2 17.4 30.4 46.7 29.6 35.6 28.5 32.6 19.7 36.7 28.1 25.0 4.2 32.6 37.1 38.5 42.1 28.5 15.6 17.1 16.2 19.8 14.5 15.0 16.8 16.0 16.1 15.3 16.8 17.2 28.9 9.6 5.8 8.1 21.4 15.2 17.7 47.7 16.5 19.1 36.3 44.8 11.0 24.3 22.2 25.8 2.1 79.5 24.0 22.9 21.5 39.6 2.1 17.6 25.0 29.2 14.4 108.6 3.3 34.1 149.1 26.9 25.5 22.3 15.2 52.3 23.9 22.3 84.9 5.0 4.7 35.7 36.7 17.0 13.9 2.1 16.4 21.7 23.2 5.6 39.3 23.0 38.1 6.0 9.2 33.7 10.6 19.2 37.6 21.7 12.7 37.7 12.9 17.4 26.3 21.4 31.2 27.5 63.4 32.6 11.9 27.5 17.4 28.2 52.2 19.5 DUT dUTPase ENSG00000128951 "Deoxyuridine triphosphatase" P33316 15 48331011-48343373 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Nucleotide metabolism" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 508.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA054422, HPA060360" Enhanced Supported Nucleoplasm No Yes 31000 "Cluster 26: Non-specific - Mitochondria" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 32: U-937 - Innate immune response" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "HPA054422: AB_2682483, HPA060360: AB_2684262" "unprognostic (1.82e-1)" "unprognostic (3.49e-2)" "unprognostic (7.89e-2)" "unprognostic (5.27e-2)" "unprognostic (2.20e-1)" "unprognostic (7.17e-2)" "unprognostic (1.65e-1)" "unprognostic (1.16e-2)" "unprognostic (4.42e-3)" "unprognostic (1.87e-2)" "unprognostic (4.25e-1)" "unprognostic (3.54e-2)" "unprognostic (3.68e-2)" "unprognostic (4.23e-2)" "unprognostic (1.47e-1)" "unprognostic (2.09e-2)" "unprognostic (1.71e-2)" 73.0 65.3 54.7 61.7 58.9 162.9 76.4 57.1 77.2 90.7 60.0 69.5 29.3 76.9 49.7 72.1 77.6 33.6 68.9 53.9 59.6 67.6 53.6 58.1 97.8 58.2 55.5 86.1 53.2 48.3 80.0 45.1 58.3 77.8 47.1 49.1 66.5 48.3 57.9 71.6 66.5 40.4 57.7 82.1 61.5 57.3 57.5 111.4 89.2 53.0 87.8 69.1 78.0 63.5 196.1 60.2 143.9 137.1 98.4 104.0 85.3 202.1 128.1 182.8 224.6 69.8 131.0 539.3 106.0 112.0 149.4 262.1 152.4 138.4 177.6 383.4 157.2 442.2 151.8 96.1 54.8 469.0 202.0 64.4 92.1 123.9 65.0 117.8 123.3 316.6 244.0 297.6 136.5 79.3 422.4 548.7 90.7 197.4 114.5 338.6 313.9 570.0 120.8 130.4 207.2 210.1 150.0 119.6 184.4 145.5 169.6 368.6 103.0 190.1 183.1 228.3 269.7 238.1 534.3 532.5 143.6 789.4 213.4 32.5 50.3 46.8 52.9 53.1 68.7 94.8 94.7 84.6 74.0 90.0 97.4 64.3 30.9 60.5 68.4 85.3 94.3 71.4 54.7 58.9 57.1 77.2 53.9 59.6 58.2 55.5 58.3 57.7 57.5 63.5 153.6 54.5 38.9 39.8 126.8 179.6 212.0 222.4 131.5 48.3 158.0 205.5 120.1 95.8 118.5 104.8 14.6 221.8 103.9 62.8 203.5 94.3 36.8 67.2 123.5 123.0 96.1 418.8 36.5 46.5 286.8 147.9 76.5 86.0 84.4 118.3 101.4 77.6 174.5 82.4 32.1 98.4 105.8 87.7 112.6 31.5 184.8 92.0 154.7 23.4 89.5 106.3 95.8 23.6 45.1 45.4 58.8 177.6 192.3 133.2 27.2 256.4 59.6 40.9 157.8 167.1 154.0 508.7 270.0 206.4 168.5 97.1 124.4 82.3 195.4 181.2 EEF1A1 "EE1A1, EEF1A, EF1A, LENG7" ENSG00000156508 "Eukaryotic translation elongation factor 1 alpha 1" P68104 6 73489308-73525587 "Cancer-related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Protein biosynthesis, Transcription, Transcription regulation" "Elongation factor" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA051759, HPA053862, HPA056990" Supported Supported Cytosol NA NA 82000000 "Cluster 30: Non-specific - Translation" "Cluster 89: Fibroblasts - ECM organization" "Cluster 30: Epithelial cell lines - Translation" "Cluster 32: Non-specific - Translation" Cytosol "HPA051759: AB_2681595, HPA053862: AB_2797248, HPA056990: AB_2683302" "unprognostic (6.47e-2)" "unprognostic (7.86e-3)" "unprognostic (2.53e-2)" "unprognostic (9.64e-2)" "unprognostic (1.39e-2)" "unprognostic (1.08e-1)" "prognostic unfavorable (5.57e-4)" "unprognostic (3.13e-1)" "unprognostic (1.61e-1)" "unprognostic (2.77e-1)" "unprognostic (1.41e-1)" "unprognostic (3.47e-1)" "unprognostic (8.61e-2)" "unprognostic (1.65e-1)" "unprognostic (8.00e-2)" "unprognostic (2.04e-1)" "unprognostic (7.73e-2)" 7265.1 5743.3 2531.3 4576.8 2717.1 10489.1 10504.6 2524.2 2783.1 7953.2 2902.2 6991.5 4783.5 7397.5 7203.8 6302.2 9034.9 4902.1 4074.6 2309.3 2687.4 7520.3 6459.1 4891.3 8813.5 2792.2 2572.6 12627.2 10370.0 6942.9 3776.4 5545.3 2828.4 5639.5 6936.4 2200.9 8381.0 6045.9 1682.1 7151.8 5076.6 7695.8 2980.6 5912.7 5776.4 1701.2 2687.7 8091.2 8348.4 1938.8 11294.9 6993.4 6470.3 2900.2 5218.1 8235.8 8697.0 13940.8 18183.0 32963.3 7874.7 7061.7 21384.2 10632.9 10044.2 12591.7 8020.5 20786.6 9976.7 13824.2 6089.1 5849.1 11729.0 15249.9 9969.0 3868.8 7099.6 7824.7 6142.2 13619.5 14708.8 15773.6 9201.9 26454.1 27514.4 7357.6 24803.6 17437.1 14783.4 8434.8 15242.2 7357.1 13131.5 8385.7 7184.5 17411.3 10348.2 6259.3 4400.0 14212.5 15389.7 26105.5 12201.5 14719.8 8337.9 8853.1 3931.6 10026.7 17535.8 9067.6 6928.7 24671.0 11535.0 4637.5 6195.9 3343.0 9206.4 7296.2 6913.1 5011.8 4780.9 12625.1 7404.1 2888.1 8472.3 895.8 7474.9 7600.7 14243.9 10580.7 12006.0 10174.3 8618.3 8426.8 13912.6 12049.7 681.7 9555.0 7680.9 6461.2 9278.5 26796.5 2531.3 2717.1 2524.2 2783.1 2309.3 2687.4 2792.2 2572.6 2828.4 2980.6 2687.7 2900.2 4915.6 3169.9 6059.2 107.4 11291.6 9829.9 12187.6 10417.5 11667.5 978.9 10528.4 9476.3 160.6 6258.2 5739.8 2637.3 546.3 9401.2 8653.6 2189.4 10344.0 5796.3 1373.9 4535.2 6754.2 5952.7 3862.8 6396.8 84.5 10404.1 12700.2 5756.1 4472.5 5831.2 3736.3 5732.4 6124.7 3323.0 6415.2 494.6 109.3 6969.3 3289.7 7779.7 8970.1 2325.8 8931.5 6705.0 5112.0 175.2 18016.6 3733.0 8468.7 76.9 162.0 7231.8 5821.6 7213.5 6811.7 11638.2 7494.7 14215.0 2974.6 1469.9 3536.8 7040.7 7075.1 1092.8 703.6 12784.4 10055.1 11086.8 9616.5 6982.9 8574.9 16180.0 EEF1A2 "EEF1AL, HS1, STN, STNL" ENSG00000101210 "Eukaryotic translation elongation factor 1 alpha 2" Q05639 20 63488013-63499239 "Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Protein biosynthesis" "Elongation factor" "Autism spectrum disorder, Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "skeletal muscle: 1638.0" "Cell type enhanced" "Detected in many" "Bipolar cells: 130.8;Cardiomyocytes: 125.5;Horizontal cells: 269.2;Rod photoreceptor cells: 50.9;Skeletal myocytes: 49.9" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "cerebral cortex: 347.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HAP1: 240.0;MCF7: 405.9;SCLC-21H: 187.0;T-47d: 157.2;U-2 OS: 202.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034019, HPA051759, HPA053862, HPA056990" Approved Approved Nucleoli,Cytosol NA NA 55000000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 80: Striated muscle - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 37: Myocytes - Muscle contraction" Cytosol Nucleoli "CAB034019: AB_1562672, HPA051759: AB_2681595, HPA053862: AB_2797248, HPA056990: AB_2683302" "unprognostic (1.40e-2)" "unprognostic (6.82e-2)" "unprognostic (4.56e-2)" "prognostic unfavorable (2.90e-5)" "unprognostic (5.17e-2)" "prognostic unfavorable (9.11e-4)" "unprognostic (4.85e-1)" "unprognostic (1.68e-1)" "unprognostic (3.02e-2)" "unprognostic (1.74e-2)" "unprognostic (2.20e-2)" "unprognostic (2.30e-1)" "unprognostic (1.86e-1)" "unprognostic (8.29e-3)" "unprognostic (1.82e-1)" "unprognostic (1.36e-2)" "unprognostic (1.07e-1)" 0.9 32.7 59.3 1.4 81.3 0.0 1.7 17.1 347.2 2.8 0.0 5.1 0.7 0.3 1.1 9.7 0.4 2.4 358.0 73.4 97.3 1.3 3.0 0.8 0.6 95.0 2.9 0.5 6.5 16.2 111.5 0.0 76.3 9.6 0.4 37.2 19.5 0.8 1638.0 6.8 1.9 0.8 0.0 0.3 8.5 1.2 30.7 0.2 0.7 320.7 0.1 2.2 1.8 125.0 0.5 71.0 0.8 16.8 0.0 0.6 7.9 10.0 1.3 51.6 16.3 9.8 41.5 0.0 110.4 0.5 13.4 38.8 240.0 0.7 115.9 0.5 13.1 0.0 24.1 4.1 2.9 0.0 13.4 1.4 2.2 0.1 1.0 0.2 0.0 0.0 3.4 0.2 0.5 405.9 1.4 0.5 11.4 95.6 96.5 8.0 0.2 10.2 2.4 3.9 187.0 89.9 90.0 12.6 1.6 2.2 157.2 3.8 0.0 0.3 202.9 0.7 1.8 0.3 0.9 1.4 0.9 0.5 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 59.3 81.3 17.1 347.2 73.4 97.3 95.0 2.9 76.3 0.0 30.7 125.0 0.1 0.0 0.0 9.4 0.7 0.4 0.9 0.0 0.0 130.8 11.8 4.6 125.5 1.5 0.6 0.0 12.5 0.0 1.1 0.4 0.0 1.3 0.2 0.5 0.3 2.2 0.0 0.0 35.5 0.2 0.2 3.6 4.6 1.4 5.7 1.0 1.1 0.1 0.0 269.2 37.2 0.0 0.0 0.3 0.7 0.5 0.0 0.6 0.0 15.0 0.0 11.7 0.0 14.6 12.7 0.3 0.0 0.0 0.3 2.6 0.0 0.5 0.0 50.9 0.0 49.9 3.4 0.0 0.3 0.0 1.8 0.0 1.5 0.0 0.5 1.1 EEF2 "EEF-2, EF2" ENSG00000167658 "Eukaryotic translation elongation factor 2" P13639 19 3976056-3985463 "Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Protein biosynthesis" "Elongation factor" "Cancer-related genes, Disease variant, FDA approved drug targets, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007795, HPA040534, HPA057351" Enhanced Enhanced "Plasma membrane,Cytosol" NA NA 17000000 "Cluster 30: Non-specific - Translation" "Cluster 50: Non-specific - Ribosome" "Cluster 30: Epithelial cell lines - Translation" "Cluster 32: Non-specific - Translation" "Plasma membrane, Cytosol" "CAB007795: AB_598149, HPA040534: AB_2677024, HPA057351: AB_2683417" "unprognostic (5.47e-2)" "unprognostic (9.59e-2)" "unprognostic (3.75e-1)" "prognostic favorable (1.81e-6)" "unprognostic (2.06e-2)" "unprognostic (3.26e-1)" "unprognostic (1.53e-2)" "unprognostic (2.11e-1)" "unprognostic (1.83e-1)" "unprognostic (1.77e-2)" "unprognostic (1.25e-2)" "unprognostic (1.42e-1)" "prognostic favorable (1.25e-5)" "unprognostic (4.46e-2)" "unprognostic (5.60e-2)" "unprognostic (6.82e-2)" "unprognostic (9.86e-2)" 1022.6 1037.0 771.8 507.3 755.2 920.3 946.7 737.2 1059.6 966.7 807.6 1122.4 821.4 887.6 563.7 1062.3 857.3 501.2 1396.6 740.9 729.1 843.2 1152.9 666.9 685.4 775.4 769.6 1627.6 3194.1 494.0 838.0 386.2 782.3 819.2 344.5 224.7 1276.4 500.3 2322.6 1142.7 798.9 385.4 758.3 721.6 1266.6 490.5 762.7 541.0 793.6 1112.4 499.0 927.8 797.7 745.1 1456.8 1018.4 579.3 1539.4 1515.6 2706.7 830.9 1110.4 1479.8 1036.7 1012.7 1618.1 652.7 3000.6 644.1 1032.3 461.1 1069.8 919.4 1719.4 544.2 755.0 1533.0 768.5 919.9 1677.0 2204.8 1668.0 1277.6 3515.5 1777.2 916.0 1404.1 1497.5 1086.6 1434.4 1526.7 2145.4 642.1 2095.7 1510.1 1266.3 1537.0 518.3 1015.7 1654.2 860.3 1938.3 871.2 1270.2 1575.4 1466.4 699.0 1377.1 2058.3 543.1 1344.7 1992.7 1321.8 738.2 765.7 1521.4 1738.7 2276.4 1644.3 1485.3 1100.4 2065.8 986.6 81.2 455.7 64.1 259.8 333.1 460.2 578.5 453.0 344.6 430.7 478.1 497.2 404.1 43.1 355.3 342.1 358.7 429.4 756.5 771.8 755.2 737.2 1059.6 740.9 729.1 775.4 769.6 782.3 758.3 762.7 745.1 323.1 221.2 392.2 24.5 1125.5 1321.1 1071.3 754.3 1269.7 212.6 981.3 694.3 627.9 597.7 448.3 255.6 77.2 958.1 535.9 556.9 986.1 716.0 799.2 318.2 675.4 568.2 744.2 934.8 23.2 1816.8 1305.0 679.7 619.3 428.5 373.4 596.1 656.8 690.6 610.1 203.6 28.9 982.1 411.0 885.4 859.5 1195.6 1008.4 514.2 645.7 36.5 907.5 429.1 614.8 27.2 42.2 868.2 815.5 832.8 992.8 1010.5 1562.7 1078.8 194.5 134.1 585.1 797.7 697.3 371.5 308.4 1343.0 1347.1 1243.1 727.1 1044.3 1168.4 1051.6 EFL1 "EFTUD1, FAM42A, FLJ13119, HsT19294, RIA1" ENSG00000140598 "Elongation factor like GTPase 1" Q7Z2Z2 15 82130233-82262734 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Protein biosynthesis, Ribosome biogenesis" "Elongation factor" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 9.2;Glandular and luminal cells: 9.5;Granulosa cells: 16.0;Pancreatic endocrine cells: 9.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039654, HPA047110, HPA052345" Uncertain Approved Cytosol NA NA "Cluster 34: Basophils - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 18: U-2197 - ECM organization" "Cluster 40: Granulosa cells - Unknown function" Cytosol "HPA039654: AB_2676610, HPA047110: AB_2797233, HPA052345: AB_2681794" "unprognostic (2.53e-1)" "unprognostic (2.04e-1)" "unprognostic (9.92e-3)" "unprognostic (8.99e-2)" "unprognostic (1.84e-1)" "unprognostic (1.60e-1)" "unprognostic (2.64e-3)" "unprognostic (3.35e-1)" "unprognostic (1.14e-1)" "unprognostic (4.75e-3)" "unprognostic (3.56e-2)" "unprognostic (3.14e-1)" "prognostic favorable (1.50e-6)" "unprognostic (8.58e-2)" "unprognostic (2.96e-1)" "unprognostic (2.60e-1)" "unprognostic (7.05e-2)" 6.2 7.4 5.0 8.2 5.3 8.8 9.9 4.9 5.4 7.3 6.7 13.3 11.6 7.1 7.5 8.3 7.7 7.0 7.3 4.6 5.4 8.6 9.3 6.9 9.6 5.0 5.1 4.9 6.2 14.7 4.6 6.9 5.7 7.2 16.5 7.2 6.7 6.8 11.6 9.0 12.8 8.8 4.8 7.0 8.3 11.2 5.3 16.6 7.8 12.4 10.8 8.1 7.2 6.0 9.8 24.5 18.0 14.9 11.7 16.1 11.6 28.0 33.1 19.9 26.1 12.2 16.7 24.0 11.4 21.4 25.2 24.9 47.5 18.5 31.8 21.8 23.1 26.8 20.2 9.3 18.3 17.0 18.3 7.9 28.9 20.5 46.0 23.7 27.0 30.8 20.5 10.8 23.6 14.1 22.5 13.9 16.0 17.5 12.6 23.8 26.4 13.3 14.1 29.7 15.8 16.8 17.7 20.5 21.6 30.7 15.6 15.1 22.9 28.1 18.5 71.6 28.6 13.4 54.9 20.1 25.1 32.2 10.5 23.1 5.7 14.6 8.6 8.2 6.9 9.4 8.0 7.5 7.0 9.9 6.9 6.0 1.0 6.5 9.9 3.3 7.9 4.8 5.0 5.3 4.9 5.4 4.6 5.4 5.0 5.1 5.7 4.8 5.3 6.0 4.1 3.2 5.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 5.7 3.9 0.0 0.0 4.3 0.0 0.0 7.1 5.5 0.0 3.9 6.8 0.0 9.2 5.1 1.4 0.0 0.0 0.0 6.0 4.0 2.5 0.0 9.5 5.1 16.0 0.0 0.0 5.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.5 0.0 0.0 2.0 0.0 0.0 0.0 0.0 9.2 0.0 0.0 0.4 0.0 0.0 5.5 7.3 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 6.8 2.9 4.9 0.0 0.0 ENTPD1 "ATPDase, CD39, NTPDase-1, SPG64" ENSG00000138185 "Ectonucleoside triphosphate diphosphohydrolase 1" P49961 10 95711779-95877266 "CD markers, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" Hydrolase "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 74.1;Kupffer cells: 110.4;Langerhans cells: 161.3;Microglial cells: 217.4;monocytes: 112.2;Plasma cells: 80.1" "Cancer enhanced" "Detected in all" "thyroid cancer: 17.9" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 102.2" "Group enriched" "Detected in all" 4 "dendritic cells: 31.9;granulocytes: 102.2;monocytes: 41.0" "Group enriched" "Detected in many" 7 "HDLM-2: 147.5;Karpas-707: 135.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002494, HPA014067, CAB079986" Enhanced Uncertain Microtubules NA NA 19000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 2: Karpas-707 - Immune response" "Cluster 41: Macrophages - Immune response" Microtubules "CAB002494: AB_563557, CAB079986: , HPA014067: AB_1848178" "unprognostic (1.14e-1)" "unprognostic (1.01e-2)" "unprognostic (3.11e-1)" "unprognostic (5.67e-2)" "unprognostic (9.68e-3)" "unprognostic (3.45e-3)" "unprognostic (6.31e-2)" "unprognostic (5.26e-3)" "unprognostic (2.73e-1)" "unprognostic (1.28e-2)" "unprognostic (6.40e-2)" "unprognostic (1.41e-1)" "prognostic unfavorable (5.33e-5)" "unprognostic (9.79e-2)" "unprognostic (2.30e-1)" "prognostic favorable (7.89e-4)" "unprognostic (5.09e-2)" 11.8 8.3 5.9 24.7 5.5 27.5 10.8 5.0 6.3 17.5 5.0 14.3 9.3 28.0 19.3 19.2 14.0 27.7 8.5 5.3 6.3 7.6 5.4 16.1 20.2 7.1 6.5 5.5 2.8 3.4 3.9 11.4 7.7 11.2 12.8 6.8 6.0 18.1 4.0 6.3 11.7 49.7 6.2 21.5 7.3 4.5 7.5 6.8 20.0 8.7 25.6 30.6 11.0 6.3 1.4 2.7 5.4 7.1 0.1 0.1 5.0 4.5 1.2 0.0 0.0 4.0 1.6 8.2 3.1 0.0 5.3 2.2 0.0 0.0 0.0 147.5 5.2 7.2 4.0 4.3 0.0 12.5 4.1 0.1 0.0 0.6 0.0 2.4 18.2 2.0 5.3 135.4 0.1 4.4 4.7 5.8 5.9 3.6 2.8 15.3 2.4 4.4 1.7 2.2 5.1 6.2 3.6 3.7 3.9 3.6 5.5 5.9 3.9 3.9 2.8 3.8 5.3 21.6 7.2 0.6 4.3 13.9 2.7 0.7 41.0 102.2 0.6 27.2 1.1 13.7 1.6 1.1 31.9 11.4 0.6 0.6 49.4 1.5 6.7 2.1 13.1 15.5 5.9 5.5 5.0 6.3 5.3 6.3 7.1 6.5 7.7 6.2 7.5 6.3 19.6 0.0 1.1 74.1 40.9 8.9 0.3 0.0 0.6 1.4 0.8 1.5 10.1 0.0 0.7 1.8 2.1 0.6 3.7 0.3 1.9 0.0 10.3 0.6 3.6 60.6 0.0 4.4 2.8 2.0 1.9 15.7 6.1 0.6 3.8 0.3 31.4 0.8 26.6 0.0 5.2 0.1 0.0 110.4 161.3 7.3 0.6 62.1 16.0 217.4 112.2 0.4 0.0 20.6 5.0 0.2 1.2 3.0 80.1 0.5 0.1 0.3 0.8 0.8 6.6 1.0 22.7 10.1 4.4 0.8 11.2 15.7 26.9 15.1 1.0 0.5 ENTPD2 "CD39L1, NTPDase-2" ENSG00000054179 "Ectonucleoside triphosphate diphosphohydrolase 2" Q9Y5L3 9 137048107-137054061 "Metabolic proteins, Predicted membrane proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 31.7" "Cell type enhanced" "Detected in many" "Leydig cells: 192.3;Paneth cells: 35.5;Peritubular cells: 96.7;Proximal enterocytes: 61.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "Hep G2: 24.3;hTCEpi: 12.7;MCF7: 16.7;OE19: 26.6;SK-BR-3: 21.6;T-47d: 23.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017676 Approved NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 45: Intestine - Brush border" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 45: Enterocytes - Digestion" "HPA017676: AB_1848179" "unprognostic (1.64e-1)" "unprognostic (3.35e-2)" "unprognostic (1.76e-1)" "unprognostic (3.33e-2)" "unprognostic (2.15e-3)" "unprognostic (1.07e-1)" "prognostic unfavorable (2.48e-5)" "unprognostic (2.71e-2)" "unprognostic (4.97e-2)" "unprognostic (3.23e-1)" "unprognostic (2.99e-1)" "unprognostic (1.89e-1)" "prognostic favorable (3.51e-6)" "prognostic favorable (1.38e-4)" "unprognostic (2.51e-1)" "unprognostic (8.43e-2)" "unprognostic (1.12e-3)" 1.0 0.8 17.5 0.9 13.0 0.2 5.0 13.3 14.8 5.9 4.3 6.8 12.2 1.8 1.6 3.3 6.1 4.5 3.4 12.5 28.1 4.7 0.9 0.4 0.1 15.9 31.7 0.7 1.8 0.9 3.0 0.7 17.1 7.3 3.8 1.0 5.5 1.6 2.0 10.2 7.8 1.0 16.7 0.1 6.1 3.5 26.4 0.2 0.6 3.4 0.3 1.2 3.6 14.5 6.5 1.7 0.0 0.1 0.1 0.0 3.9 0.0 0.0 0.0 0.0 1.2 1.9 0.0 1.4 0.0 0.0 5.1 0.5 3.7 0.0 0.0 0.2 0.0 0.8 24.3 0.0 0.0 0.3 0.0 12.7 0.0 3.3 0.3 0.0 0.0 0.0 0.0 0.0 16.7 0.0 0.0 0.0 26.6 3.6 0.0 1.1 2.5 2.8 0.6 3.5 0.1 0.3 21.6 0.0 0.1 23.4 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.5 13.0 13.3 14.8 12.5 28.1 15.9 31.7 17.1 16.7 26.4 14.5 1.1 0.0 0.0 19.2 0.5 1.7 1.9 2.8 4.0 0.2 8.0 13.2 0.5 11.5 1.8 0.0 0.0 0.3 0.0 26.2 0.0 6.2 1.4 12.1 1.5 1.2 25.2 0.0 0.2 4.3 1.1 1.5 5.1 2.8 0.0 0.0 0.4 1.1 0.2 0.0 0.1 9.4 6.1 0.0 0.0 6.2 192.3 0.3 5.4 1.9 0.6 6.8 0.0 0.5 0.1 6.0 35.5 96.7 0.0 4.4 61.8 8.6 3.2 0.1 0.0 0.4 4.1 1.2 4.4 1.8 1.4 1.0 0.2 0.0 16.0 1.5 ENTPD3 "CD39L3, HB6, NTPDase-3" ENSG00000168032 "Ectonucleoside triphosphate diphosphohydrolase 3" O75355 3 40387184-40428744 "Enzymes, Metabolic proteins, Predicted membrane proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 20.8;cervix: 21.3;salivary gland: 22.4" "Cell type enriched" "Detected in many" 4 "Inhibitory neurons: 92.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 7 "plasmacytoid DC: 3.5" "Lineage enriched" "Detected in single" 7 "dendritic cells: 3.5" "Cell line enhanced" "Detected in some" "HaCaT: 3.6;HBEC3-KT: 13.0;hTCEpi: 8.4;RT4: 18.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 15: RT4 - Unknown function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (1.00e-1)" "unprognostic (1.54e-2)" "unprognostic (2.75e-2)" "unprognostic (9.84e-3)" "unprognostic (2.27e-2)" "unprognostic (2.04e-1)" "unprognostic (1.80e-1)" "unprognostic (1.18e-2)" "unprognostic (8.40e-2)" "unprognostic (9.88e-3)" "unprognostic (4.72e-2)" "unprognostic (2.08e-1)" "unprognostic (3.25e-1)" "unprognostic (6.53e-2)" "unprognostic (5.99e-2)" "unprognostic (1.68e-1)" "unprognostic (1.23e-1)" 4.2 1.3 3.4 1.1 20.8 0.1 2.4 2.0 6.5 21.3 0.8 3.5 1.3 3.1 2.4 6.5 0.9 2.0 0.6 4.5 4.5 2.6 0.1 3.9 0.4 6.2 4.0 1.7 15.8 0.5 2.9 0.5 6.1 3.4 2.8 2.6 22.4 4.0 1.2 2.9 1.4 1.9 2.2 4.2 6.8 0.5 5.3 0.9 5.5 2.5 1.7 13.0 3.6 4.7 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.1 3.6 0.0 13.0 0.3 0.4 0.4 0.5 0.2 0.0 0.0 0.0 0.0 0.1 8.4 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.5 0.0 0.1 0.1 0.2 1.0 0.0 0.0 0.0 1.5 18.4 1.8 0.2 0.4 1.1 0.2 0.3 0.6 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.3 0.1 0.5 0.1 0.0 0.5 0.0 0.0 0.1 0.1 0.2 0.0 0.0 0.1 0.0 0.1 0.2 0.2 0.0 0.4 0.0 3.5 0.2 0.0 3.4 20.8 2.0 6.5 4.5 4.5 6.2 4.0 6.1 2.2 5.3 4.7 5.5 3.2 4.2 4.9 0.2 2.3 1.3 2.3 8.0 0.7 6.1 0.3 0.5 0.0 5.1 0.0 0.0 0.0 1.3 1.0 0.0 2.7 0.4 7.6 2.5 0.7 2.4 0.0 22.6 22.5 0.0 0.4 2.6 14.9 0.0 0.0 0.0 0.0 0.1 0.0 92.6 0.1 0.0 0.0 0.8 0.0 0.3 0.3 0.0 1.9 0.0 3.7 0.0 7.1 5.9 6.9 0.0 0.7 0.1 1.4 0.0 0.0 1.9 0.8 19.7 0.6 19.9 0.2 0.1 14.5 2.3 0.0 0.2 0.1 0.2 4.7 ENTPD4 "KIAA0392, LALP70, LAP70, LYSAL1, NTPDase-4, UDPase" ENSG00000197217 "Ectonucleoside triphosphate diphosphohydrolase 4" Q9Y227 8 23385783-23457695 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017655 Supported Approved Vesicles NA NA 82000 "Cluster 2: Granulocytes - Unknown function" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 52: Non-specific - Transcription" Vesicles "HPA017655: AB_1848181" "unprognostic (2.83e-2)" "unprognostic (1.50e-2)" "unprognostic (1.23e-3)" "unprognostic (1.38e-1)" "unprognostic (5.06e-2)" "unprognostic (7.86e-3)" "unprognostic (2.00e-2)" "unprognostic (2.99e-3)" "unprognostic (2.07e-2)" "unprognostic (8.74e-2)" "unprognostic (2.82e-1)" "unprognostic (1.20e-1)" "unprognostic (4.55e-2)" "unprognostic (1.39e-1)" "unprognostic (1.11e-1)" "unprognostic (6.62e-2)" "unprognostic (3.72e-2)" 16.3 11.5 8.6 24.2 10.5 30.5 14.8 11.1 16.2 17.0 8.1 19.8 18.1 16.8 17.3 12.6 13.7 14.6 21.2 10.8 12.3 12.2 13.7 20.0 29.3 13.1 9.2 13.5 21.4 27.2 18.3 17.2 12.8 16.8 20.3 32.7 22.0 13.4 15.2 12.4 26.2 16.5 7.6 25.4 20.3 19.9 12.5 14.5 14.7 15.9 29.8 16.7 16.6 11.6 20.8 28.7 34.0 23.5 29.0 36.8 35.0 33.1 30.4 21.3 33.2 40.3 26.4 35.5 22.9 32.8 32.9 24.5 15.8 29.0 40.3 8.6 11.5 18.4 18.1 14.2 23.7 9.8 34.8 22.8 34.7 28.4 29.9 51.9 31.2 26.7 13.2 30.6 36.4 9.3 14.8 11.9 20.1 26.2 10.2 14.3 34.6 10.8 27.0 24.1 27.2 26.6 12.0 17.0 23.7 67.0 12.9 13.6 38.6 39.1 38.3 43.7 24.1 24.7 11.5 45.5 51.3 11.5 39.4 17.0 5.7 13.4 7.4 8.6 8.8 8.7 7.3 8.1 7.5 6.5 9.2 7.3 14.4 4.8 7.0 6.8 6.3 6.9 8.6 10.5 11.1 16.2 10.8 12.3 13.1 9.2 12.8 7.6 12.5 11.6 15.9 19.2 34.5 10.7 25.8 6.5 12.0 17.6 8.6 32.1 11.4 8.6 24.6 7.2 27.3 14.7 14.6 16.1 33.4 25.1 0.0 15.6 8.6 13.6 21.6 15.8 17.3 10.3 31.4 16.9 16.9 16.9 23.9 23.9 17.7 18.9 12.1 11.5 12.3 47.1 37.4 19.7 20.3 14.2 15.5 19.2 7.2 18.2 12.4 19.7 19.4 15.2 18.6 23.1 23.1 21.8 13.3 8.6 46.9 18.9 18.8 5.0 15.0 35.9 13.1 14.3 14.6 21.5 22.8 9.5 5.5 20.2 21.3 11.7 12.4 18.9 ENTPD5 "CD39L4, NTPDase-5, PCPH" ENSG00000187097 "Ectonucleoside triphosphate diphosphohydrolase 5 (inactive)" O75356 14 73958010-74019399 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" Hydrolase Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 107.2;kidney: 95.2;liver: 263.7" "Cell type enhanced" "Detected in all" "Distal enterocytes: 209.3;Hepatocytes: 134.8;Intestinal goblet cells: 77.1;Proximal enterocytes: 87.0" "Group enriched" "Detected in all" 5 "liver cancer: 18.2;prostate cancer: 39.9" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "basophil: 18.3;eosinophil: 9.4" "Lineage enriched" "Detected in many" 7 "granulocytes: 18.3" "Cell line enhanced" "Detected in all" "RT4: 57.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002927 Enhanced "Secreted to blood" NA NA 5900000 "Cluster 46: Basophils - DNA binding" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 15: RT4 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA002927: AB_1078744" "unprognostic (4.19e-1)" "unprognostic (9.63e-3)" "unprognostic (3.11e-2)" "unprognostic (2.06e-2)" "unprognostic (1.98e-1)" "unprognostic (3.87e-2)" "unprognostic (1.46e-1)" "unprognostic (1.19e-1)" "unprognostic (3.34e-1)" "unprognostic (6.01e-2)" "unprognostic (6.20e-2)" "unprognostic (2.55e-1)" "prognostic favorable (3.95e-5)" "unprognostic (1.25e-1)" "unprognostic (5.06e-2)" "unprognostic (1.76e-1)" "unprognostic (6.92e-3)" 8.2 7.7 5.0 11.4 7.3 8.0 12.4 7.1 6.7 7.3 7.1 94.6 72.1 6.3 7.7 11.3 5.7 12.1 7.7 5.1 6.3 95.2 263.7 6.5 5.5 7.6 7.3 6.7 4.9 7.7 5.0 5.6 7.8 37.7 107.2 9.4 10.7 4.4 15.0 8.1 68.4 9.7 6.5 6.0 42.3 8.6 7.3 4.6 6.1 9.1 5.6 16.9 7.2 9.0 9.5 7.8 8.2 15.1 16.5 15.5 9.4 9.6 7.9 6.4 7.1 5.6 10.9 10.6 4.7 12.8 6.0 10.8 8.5 14.1 7.2 8.8 4.0 7.9 5.7 30.9 15.5 4.7 8.8 12.9 14.0 8.7 18.2 8.8 13.1 17.1 8.8 15.4 9.7 13.6 5.4 5.6 2.5 8.5 15.7 6.0 8.0 5.2 11.4 57.1 5.8 6.0 16.6 12.9 9.2 6.4 18.7 4.1 10.8 12.6 12.7 7.5 7.2 10.1 16.9 8.3 8.0 8.8 11.5 18.3 1.2 9.4 2.5 2.3 1.3 1.4 1.3 1.8 1.7 1.5 2.1 2.1 0.1 0.5 1.4 0.9 1.6 1.3 5.0 7.3 7.1 6.7 5.1 6.3 7.6 7.3 7.8 6.5 7.3 9.0 8.0 16.0 6.7 8.1 4.9 3.7 6.2 8.9 5.2 6.6 15.0 7.9 5.2 10.0 11.3 7.3 4.2 8.2 4.3 209.3 25.4 6.9 19.5 10.0 13.6 7.0 16.2 36.6 5.9 12.9 6.7 7.9 23.0 25.8 1.3 9.6 9.7 134.8 6.2 10.1 8.2 77.1 14.2 9.7 1.9 12.7 2.8 5.2 5.4 11.2 5.4 4.9 8.2 2.0 11.3 9.1 58.4 5.7 3.6 28.5 87.0 63.1 6.4 12.2 13.1 6.0 5.9 27.2 19.1 8.5 3.4 3.3 4.9 10.3 60.9 39.0 ENTPD6 "CD39L2, dJ738P15.3, IL6ST2, NTPDase-6" ENSG00000197586 "Ectonucleoside triphosphate diphosphohydrolase 6" O75354 20 25195693-25228075 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SK-MEL-30: 289.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015491, HPA069555" Approved Supported "Golgi apparatus" "Secreted to blood" NA NA 41000 "Cluster 39: Non-specific - mRNA processing" "Cluster 22: Non-specific - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 53: Intestinal epithelial cells - Unknown function" "Golgi apparatus" "HPA015491: AB_2669200, HPA069555: AB_2686152" "unprognostic (3.24e-1)" "unprognostic (1.27e-2)" "unprognostic (5.91e-2)" "unprognostic (1.16e-1)" "unprognostic (1.76e-1)" "unprognostic (4.44e-1)" "unprognostic (2.10e-3)" "unprognostic (7.41e-3)" "unprognostic (2.74e-3)" "unprognostic (1.17e-1)" "unprognostic (2.14e-1)" "unprognostic (1.03e-1)" "unprognostic (8.14e-3)" "unprognostic (1.78e-2)" "unprognostic (2.74e-1)" "unprognostic (4.86e-2)" "unprognostic (4.48e-2)" 24.8 55.4 54.3 22.8 64.0 15.2 27.7 39.7 65.9 22.9 26.5 61.0 60.0 21.8 18.4 25.3 23.2 26.5 75.9 56.0 49.8 40.4 38.9 25.4 16.1 29.6 32.2 36.2 49.6 23.5 60.0 25.2 45.2 55.7 44.9 15.7 71.2 17.2 38.7 19.4 63.0 18.6 25.7 19.8 47.2 36.3 48.5 29.8 28.8 21.9 13.0 24.5 21.8 38.9 78.8 122.8 32.9 64.0 41.0 50.8 70.8 63.0 45.0 54.0 48.3 65.5 60.0 47.6 91.4 60.9 104.7 100.3 40.1 96.2 35.5 29.2 36.2 38.3 18.2 150.4 60.7 52.7 57.3 47.4 53.1 67.7 51.4 39.4 43.7 46.1 51.5 78.8 40.0 75.6 49.2 32.6 20.8 63.9 96.0 27.1 102.9 108.4 67.8 46.3 52.0 26.7 17.7 105.1 289.4 29.6 75.3 43.4 48.6 61.9 63.7 51.6 75.7 50.5 43.8 21.0 44.5 34.1 116.3 0.1 25.2 4.9 18.8 17.0 25.6 8.7 16.5 15.0 26.4 11.0 16.9 15.5 1.1 14.1 7.6 18.5 17.2 22.1 54.3 64.0 39.7 65.9 56.0 49.8 29.6 32.2 45.2 25.7 48.5 38.9 6.4 19.2 28.5 12.4 9.9 9.8 16.2 23.6 6.2 19.2 25.8 21.8 5.8 25.8 14.8 18.4 10.4 63.2 11.0 81.4 9.8 42.5 22.1 10.5 7.6 7.6 34.0 4.2 18.6 40.1 21.7 12.8 52.5 15.4 3.8 65.2 14.3 15.0 26.7 25.2 19.4 57.5 26.4 17.7 17.4 65.2 20.5 17.6 10.6 11.2 16.0 4.2 10.3 13.0 9.2 33.8 59.8 42.2 16.5 27.9 68.4 13.5 10.7 9.1 6.6 6.3 9.6 3.0 8.8 8.6 6.0 59.8 12.0 25.8 72.6 12.1 ENTPD8 "NTPDase-8, UNQ2492" ENSG00000188833 "Ectonucleoside triphosphate diphosphohydrolase 8" Q5MY95 9 137434364-137441816 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 27.6;liver: 14.5" "Group enriched" "Detected in some" 5 "Distal enterocytes: 194.5;Intestinal goblet cells: 181.0;Paneth cells: 174.3;Proximal enterocytes: 167.3" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CAPAN-2: 5.0;OE19: 1.7;RPMI-8226: 5.3;T-47d: 2.8" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA021509 Enhanced Approved Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 25: RPMI-8226 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Cytosol" Vesicles "HPA021509: AB_1848185" "unprognostic (3.85e-2)" "unprognostic (8.33e-2)" "unprognostic (2.11e-1)" "unprognostic (1.82e-1)" "unprognostic (1.30e-1)" "unprognostic (1.40e-1)" "unprognostic (6.46e-3)" "unprognostic (8.70e-2)" "unprognostic (3.87e-2)" "unprognostic (8.48e-2)" "unprognostic (1.69e-1)" "unprognostic (2.34e-2)" "unprognostic (1.08e-5)" "prognostic favorable (7.17e-4)" "unprognostic (2.17e-1)" "unprognostic (1.15e-1)" "unprognostic (1.78e-1)" 0.0 0.0 0.0 1.4 0.0 0.4 0.4 0.2 0.2 0.6 0.0 21.3 27.6 0.1 0.0 0.3 0.7 3.7 0.0 0.0 0.0 3.1 14.5 0.1 0.1 0.2 0.1 0.1 3.1 0.1 5.1 0.1 0.0 0.4 11.2 0.0 6.3 0.2 0.0 0.1 27.2 0.1 0.0 0.2 8.9 0.5 0.0 0.3 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.1 1.1 5.0 0.0 0.3 0.0 0.4 0.1 0.0 0.0 0.0 1.0 0.1 0.0 0.4 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.0 1.0 0.0 0.1 0.0 1.7 0.2 0.0 0.0 5.3 0.7 0.0 0.2 0.5 0.1 0.0 0.1 0.4 2.8 0.1 0.0 0.0 1.2 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.2 0.0 0.0 1.7 1.5 0.4 11.5 0.3 20.2 0.0 0.0 0.1 194.5 0.0 1.3 0.0 3.0 0.4 0.1 3.6 0.0 0.0 7.5 0.2 0.1 31.6 4.7 0.0 0.1 0.4 10.1 0.1 0.0 0.0 181.0 8.2 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 174.3 0.0 0.2 0.6 167.3 5.9 1.0 0.0 0.0 0.0 0.1 0.0 0.7 0.0 0.0 0.3 0.3 0.1 15.6 1.7 GART "GARS-AIRS-GART, PGFT, PRGS" ENSG00000159131 "Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" P22102 21 33503931-33543491 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Purine biosynthesis" "Ligase, Multifunctional enzyme, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002119, HPA005779" Approved Approved Mitochondria,Cytosol NA NA 300000 "Cluster 27: Non-specific - Gene expression" "Cluster 3: T-cells - Adaptive immune response" "Cluster 1: K-562 - Erythropoiesis" "Cluster 39: Non-specific - Basic cellular processes" Cytosol Mitochondria "HPA002119: AB_1849482, HPA005779: AB_1849484" "unprognostic (3.77e-2)" "unprognostic (2.25e-2)" "unprognostic (4.51e-3)" "unprognostic (1.72e-2)" "unprognostic (2.30e-2)" "prognostic unfavorable (5.05e-5)" "prognostic unfavorable (9.82e-5)" "unprognostic (2.50e-2)" "unprognostic (2.76e-3)" "unprognostic (2.92e-1)" "prognostic unfavorable (2.19e-4)" "unprognostic (1.98e-3)" "prognostic unfavorable (3.95e-6)" "unprognostic (1.36e-2)" "unprognostic (2.31e-1)" "unprognostic (2.28e-1)" "unprognostic (1.57e-1)" 24.1 20.3 9.2 24.2 12.2 18.8 24.3 11.3 11.9 16.4 10.1 23.2 22.1 18.3 17.1 24.8 21.8 15.9 20.7 8.6 10.5 21.0 29.7 16.0 30.3 11.0 10.3 19.0 22.3 19.9 12.8 26.1 11.7 17.0 29.1 20.9 16.8 16.7 29.1 17.4 19.4 26.3 11.3 20.0 19.7 29.3 10.9 34.4 20.8 21.9 38.6 32.2 16.5 14.0 132.2 61.5 90.3 98.8 61.1 64.2 100.3 82.6 70.8 96.8 101.5 117.7 108.9 174.8 48.5 55.6 124.9 67.9 189.0 130.4 138.3 91.3 111.7 265.2 68.5 78.6 85.2 148.6 66.3 57.3 86.5 113.3 162.5 48.1 91.5 138.4 312.4 108.5 84.9 63.6 158.2 100.0 194.4 186.3 71.8 131.1 166.6 246.7 74.7 69.4 93.1 84.1 116.9 89.1 107.1 81.0 113.0 93.9 68.7 64.9 76.9 56.1 90.9 106.8 159.6 193.0 67.1 171.3 96.2 9.0 24.0 16.3 25.9 33.9 31.4 29.7 25.2 27.1 31.6 24.5 26.4 26.2 10.6 43.9 30.6 23.2 34.1 22.8 9.2 12.2 11.3 11.9 8.6 10.5 11.0 10.3 11.7 11.3 10.9 14.0 21.1 19.2 19.8 17.3 30.1 46.0 50.3 34.1 38.1 18.5 18.6 17.3 19.3 11.5 28.0 14.7 35.5 41.2 21.8 12.4 23.5 28.4 21.7 23.3 36.9 21.9 13.1 40.3 19.1 24.2 37.4 27.2 21.4 23.4 7.6 31.8 16.1 18.0 23.6 5.0 21.1 17.1 22.4 17.0 12.0 6.6 17.4 17.0 12.4 10.3 19.8 13.3 22.6 17.6 19.3 31.5 12.7 18.0 22.7 54.3 16.4 14.3 17.8 28.5 13.1 23.0 23.9 57.2 27.6 34.4 45.9 25.6 21.2 55.0 24.1 46.6 GFM1 "EFGM, EGF1, GFM, mtEF-G1" ENSG00000168827 "G elongation factor mitochondrial 1" Q96RP9 3 158644527-158695581 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Protein biosynthesis" "Elongation factor" "Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034764, HPA034765, HPA061405" Enhanced Approved Nucleoplasm,Mitochondria NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Mitochondria Nucleoplasm "HPA034764: AB_2674320, HPA034765: AB_10669849, HPA061405: AB_2684505" "unprognostic (1.26e-1)" "unprognostic (1.61e-1)" "unprognostic (5.48e-3)" "unprognostic (4.48e-3)" "unprognostic (1.84e-1)" "unprognostic (3.40e-1)" "unprognostic (4.75e-2)" "unprognostic (6.05e-2)" "unprognostic (2.48e-1)" "unprognostic (8.36e-2)" "prognostic unfavorable (9.20e-4)" "unprognostic (2.79e-1)" "prognostic favorable (1.16e-7)" "unprognostic (1.62e-1)" "unprognostic (4.78e-1)" "unprognostic (3.32e-2)" "unprognostic (8.78e-2)" 26.7 25.0 12.3 21.7 13.2 24.1 27.8 18.1 21.3 14.1 16.8 30.1 24.9 17.2 20.8 24.1 13.4 17.5 39.0 13.0 15.5 43.7 49.6 18.8 20.7 14.5 13.2 12.7 26.4 40.1 12.0 25.7 15.3 19.6 31.5 46.4 21.0 21.9 63.0 15.2 19.8 20.9 13.7 16.4 23.9 23.5 14.1 16.6 32.1 60.2 20.7 23.5 12.9 15.7 92.2 55.9 25.5 32.0 41.8 30.6 34.2 42.6 49.8 75.9 57.4 73.2 58.7 73.9 54.7 39.2 32.0 55.9 62.5 47.8 84.3 40.6 33.7 56.1 34.6 34.3 48.6 76.7 35.9 37.3 55.7 43.8 41.0 17.6 50.2 43.0 71.7 50.3 67.9 56.9 49.6 30.6 55.7 97.0 29.8 49.8 28.0 132.6 51.0 38.3 48.9 42.8 63.8 96.1 79.1 19.9 132.1 60.0 28.0 46.4 21.0 69.4 74.1 82.7 61.4 138.9 41.8 65.0 52.4 18.9 19.3 13.8 22.2 27.2 28.6 17.0 19.3 23.0 23.3 16.4 22.1 23.9 3.0 25.4 22.0 11.2 17.4 18.4 12.3 13.2 18.1 21.3 13.0 15.5 14.5 13.2 15.3 13.7 14.1 15.7 31.4 19.2 19.0 17.0 26.1 21.5 26.0 20.9 20.5 57.3 23.0 11.9 54.8 22.8 18.9 12.9 31.3 31.6 20.1 22.2 11.7 19.9 15.4 12.4 20.2 36.6 19.3 29.0 39.8 25.0 17.6 20.9 22.4 14.8 19.0 17.7 22.5 61.6 29.0 15.2 43.9 24.5 30.5 20.4 21.5 7.6 22.7 21.7 17.8 18.7 33.8 27.3 16.5 22.6 43.3 20.3 10.5 17.0 19.2 21.7 22.1 37.9 25.1 51.6 13.1 21.5 23.4 34.4 31.6 20.1 21.0 30.8 22.3 41.4 28.9 22.0 GFM2 "EF-G2mt, EFG2, FLJ21661" ENSG00000164347 "GTP dependent ribosome recycling factor mitochondrial 2" Q969S9 5 74721206-74767147 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Protein biosynthesis" "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Respiratory ciliated cells: 61.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036863, HPA069871" Uncertain Approved "Nucleoplasm,Midbody ring,Mitochondria" Yes NA "Cluster 11: Basophils - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 49: Ciliated cells - Cilium organization" Mitochondria "Nucleoplasm, Midbody ring" "HPA036863: AB_2675354, HPA069871: " "unprognostic (2.58e-3)" "unprognostic (7.04e-2)" "unprognostic (8.54e-3)" "unprognostic (1.98e-1)" "unprognostic (4.49e-2)" "unprognostic (2.05e-2)" "unprognostic (1.73e-1)" "unprognostic (1.64e-1)" "unprognostic (1.40e-1)" "unprognostic (3.80e-2)" "unprognostic (2.10e-2)" "unprognostic (1.29e-1)" "prognostic favorable (1.33e-5)" "unprognostic (9.55e-2)" "unprognostic (4.15e-1)" "unprognostic (8.52e-3)" "unprognostic (9.82e-2)" 9.6 18.1 9.7 10.2 10.5 15.0 14.1 10.2 14.5 10.7 16.1 13.9 9.3 11.1 17.4 11.9 23.4 9.0 33.3 10.8 10.7 23.3 34.0 9.0 12.2 9.5 9.1 11.4 10.0 30.4 10.7 13.5 10.0 13.0 15.8 16.8 13.4 11.2 30.6 11.3 10.8 10.8 9.4 8.5 17.9 15.8 10.2 17.2 13.1 38.5 15.5 12.9 7.0 11.1 39.5 34.3 27.2 52.2 20.3 27.1 28.2 41.5 24.7 41.5 44.1 36.4 24.9 39.7 44.9 21.9 65.7 32.1 55.0 59.6 54.8 34.8 35.5 22.9 31.7 27.0 27.1 23.6 26.0 32.1 26.3 33.6 40.5 29.8 30.3 39.4 40.7 32.9 48.5 23.3 32.1 15.1 11.4 14.8 29.7 41.1 43.5 49.3 32.0 24.7 46.6 24.8 46.3 38.1 44.3 30.1 33.0 44.0 24.0 16.2 27.8 20.5 27.2 19.0 38.3 40.1 24.1 34.2 24.6 22.8 6.9 9.2 6.7 7.2 6.6 8.3 5.5 7.5 6.7 7.2 7.5 7.3 3.5 16.0 11.8 4.4 7.0 5.2 9.7 10.5 10.2 14.5 10.8 10.7 9.5 9.1 10.0 9.4 10.2 11.1 6.4 12.8 12.9 19.9 8.5 6.0 7.1 13.0 8.6 9.1 7.7 6.9 11.0 7.2 12.5 7.3 6.2 20.1 7.5 8.9 21.5 9.5 11.5 42.4 9.2 6.4 5.4 17.9 35.7 5.3 15.9 6.3 15.3 13.7 2.5 10.4 5.3 22.4 9.9 16.8 34.1 9.7 30.5 8.5 2.4 2.6 7.2 6.8 8.8 13.1 17.9 13.0 7.2 34.2 29.1 9.8 9.9 7.5 11.4 4.6 8.5 11.2 61.5 9.6 0.0 5.6 7.8 15.2 11.7 10.0 7.0 16.0 7.3 11.1 10.0 7.5 IL18BP IL18BPa ENSG00000137496 "Interleukin 18 binding protein" O95998 11 71998613-72005715 "Disease related genes, Metabolic proteins, Predicted secreted proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 49.2" "Cell type enhanced" "Detected in many" "Adipocytes: 14.0;Exocrine glandular cells: 13.6;Kupffer cells: 14.2;Langerhans cells: 12.9;Macrophages: 15.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025980, HPA041061" Enhanced Approved "Endoplasmic reticulum" "Secreted to blood" NA NA 3070000 16000000 "Cluster 52: Eosinophils - Transcription" "Cluster 64: Macrophages - Immune response" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Endoplasmic reticulum" "CAB025980: , HPA041061: AB_2677280" "unprognostic (2.66e-3)" "unprognostic (2.04e-3)" "unprognostic (9.14e-3)" "unprognostic (1.70e-2)" "unprognostic (5.58e-3)" "unprognostic (7.75e-2)" "unprognostic (1.41e-1)" "unprognostic (6.20e-2)" "unprognostic (1.19e-2)" "unprognostic (1.75e-3)" "unprognostic (1.74e-1)" "unprognostic (1.51e-1)" "prognostic unfavorable (2.93e-6)" "unprognostic (1.19e-1)" "unprognostic (4.14e-2)" "unprognostic (6.76e-2)" "unprognostic (1.93e-2)" 14.4 18.4 6.0 25.0 6.3 7.9 13.6 7.1 9.1 12.5 4.9 12.7 8.3 10.4 3.5 6.4 10.1 8.1 10.9 5.8 8.3 24.9 15.0 31.1 26.2 8.7 7.8 11.1 8.4 2.5 10.7 17.1 9.0 16.5 11.0 3.8 8.9 4.2 5.0 7.4 17.2 13.5 6.1 49.2 10.2 6.1 8.5 6.5 12.6 2.4 11.9 12.2 8.5 7.3 1.7 2.3 5.1 2.9 1.0 1.6 5.9 3.3 1.8 3.0 4.0 11.7 2.4 1.2 2.2 1.3 3.4 4.0 2.5 2.4 2.0 2.5 3.8 4.5 7.6 3.7 1.3 2.4 12.3 2.4 2.3 2.4 1.2 3.5 6.3 7.9 7.4 2.0 1.8 3.2 3.8 5.7 3.6 1.9 2.2 6.1 5.4 1.9 2.1 4.4 2.8 5.3 3.0 4.2 3.7 4.8 3.6 2.7 13.6 4.2 3.5 5.1 1.9 3.3 1.8 2.1 1.7 11.5 2.3 7.0 20.2 56.1 52.5 72.9 23.9 31.9 27.5 31.6 36.9 20.2 22.5 32.5 8.6 5.2 60.9 53.7 15.1 39.8 6.0 6.3 7.1 9.1 5.8 8.3 8.7 7.8 9.0 6.1 8.5 7.3 14.0 6.4 3.3 0.7 8.0 2.0 0.4 0.7 0.0 3.3 2.1 1.9 1.8 1.5 1.0 0.0 10.4 1.0 7.2 0.5 0.0 3.0 0.0 1.1 1.9 11.1 0.0 0.8 0.7 13.6 1.4 3.4 1.1 1.8 7.6 2.2 10.4 0.5 11.2 3.3 0.5 0.8 0.0 14.2 12.9 0.0 0.9 15.4 0.0 1.0 4.6 1.1 7.2 0.5 0.0 5.4 0.2 0.7 2.3 1.0 1.1 1.9 1.8 3.7 0.0 1.8 1.6 0.7 0.5 0.6 2.0 0.8 6.4 1.6 0.8 0.2 ITPA "C20orf37, dJ794I6.3, HLC14-06-P" ENSG00000125877 "Inosine triphosphatase" Q9BY32 20 3208868-3223870 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Nucleotide metabolism" Hydrolase "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022824, HPA073963" Approved Supported Nucleoplasm,Cytosol NA NA 120000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 37: Intestine - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Cytosol" "HPA022824: AB_1851960, HPA073963: " "unprognostic (1.58e-2)" "unprognostic (1.98e-1)" "unprognostic (1.73e-1)" "unprognostic (3.57e-1)" "unprognostic (4.63e-2)" "unprognostic (1.53e-2)" "prognostic unfavorable (2.54e-5)" "unprognostic (1.11e-2)" "unprognostic (1.68e-1)" "unprognostic (1.76e-1)" "unprognostic (1.83e-1)" "unprognostic (2.28e-1)" "unprognostic (1.94e-2)" "unprognostic (8.34e-2)" "unprognostic (3.63e-1)" "unprognostic (1.24e-1)" "unprognostic (1.84e-1)" 26.2 37.1 16.7 21.2 17.5 26.4 25.0 16.9 20.0 24.8 18.2 25.3 27.0 24.0 13.0 43.9 29.9 16.7 20.8 18.2 16.8 34.2 28.2 22.4 27.6 17.0 16.5 21.2 21.9 24.2 13.0 19.8 17.0 20.3 19.2 6.9 26.4 16.1 26.5 33.6 23.2 18.5 17.3 27.0 27.1 12.3 18.0 24.8 33.5 15.1 21.4 24.1 25.7 18.5 118.2 91.1 44.0 49.1 29.7 42.7 30.9 50.9 72.4 65.9 58.8 75.0 106.6 52.5 46.9 48.7 65.7 101.9 62.3 79.8 46.6 32.9 91.6 123.9 39.1 117.6 55.5 54.5 41.4 41.5 60.3 64.4 40.9 28.6 52.5 39.5 88.7 34.2 62.6 55.2 66.0 156.5 77.2 132.1 89.6 61.4 60.7 135.0 96.7 39.2 67.4 80.9 41.4 154.0 106.3 19.3 60.1 94.2 37.9 76.5 42.4 51.7 116.0 52.0 68.4 94.2 32.9 102.8 83.0 32.8 61.5 22.9 47.7 78.2 41.7 48.9 43.6 49.0 74.5 50.2 32.4 39.5 3.4 64.5 56.9 70.7 61.0 48.0 16.7 17.5 16.9 20.0 18.2 16.8 17.0 16.5 17.0 17.3 18.0 18.5 29.4 22.4 47.0 15.3 38.0 40.1 50.5 93.2 56.9 20.4 48.8 58.3 9.8 34.3 59.3 44.1 14.6 74.4 45.9 37.5 58.7 104.2 2.7 51.8 64.4 29.4 27.5 24.6 12.0 105.1 128.2 41.8 48.4 60.9 42.5 49.7 29.3 32.1 116.6 5.0 9.2 53.1 54.9 42.4 54.0 3.7 31.1 49.0 40.9 5.6 90.3 21.0 41.2 14.1 21.5 102.2 59.9 22.2 34.5 53.5 51.6 94.5 37.9 24.5 19.7 35.4 45.0 16.8 17.6 58.8 49.2 56.2 47.2 53.3 79.9 66.0 MTPAP "FLJ10486, PAPD1, SPAX4, TENT6" ENSG00000107951 "Mitochondrial poly(A) polymerase" Q9NVV4 10 30309801-30374448 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "mRNA processing, Transcription" "Nucleotidyltransferase, RNA-binding, Transferase" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 36.8" "Cell type enriched" "Detected in many" 7 "Early spermatids: 240.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038620, HPA058232" Approved Supported Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 23: Spermatids - Flagellum & Golgi organization" Mitochondria "HPA038620: AB_10673015, HPA058232: AB_2683646" "unprognostic (2.76e-2)" "unprognostic (2.04e-1)" "unprognostic (1.73e-1)" "unprognostic (3.43e-3)" "unprognostic (3.05e-2)" "unprognostic (1.01e-1)" "prognostic unfavorable (4.20e-6)" "unprognostic (1.16e-1)" "unprognostic (2.04e-1)" "unprognostic (4.78e-2)" "unprognostic (1.77e-1)" "unprognostic (3.56e-2)" "unprognostic (9.02e-2)" "unprognostic (6.28e-3)" "unprognostic (3.77e-1)" "unprognostic (1.14e-2)" "unprognostic (4.39e-2)" 8.9 7.4 4.9 10.3 4.8 36.8 9.7 12.6 6.7 6.1 3.1 9.6 10.6 9.0 6.2 8.3 6.6 5.2 8.8 4.8 4.3 9.6 10.6 6.3 10.7 3.4 3.5 8.2 10.0 8.4 2.7 9.6 3.9 7.2 11.0 7.1 8.0 4.9 13.2 8.4 9.0 9.1 3.2 9.3 7.1 5.1 3.6 9.2 10.2 12.0 10.3 8.1 5.2 6.2 26.0 25.3 15.8 23.0 15.2 14.2 20.6 17.6 6.2 17.7 18.4 27.0 35.4 36.9 12.3 11.7 16.3 29.7 31.1 20.7 21.6 18.7 24.0 37.3 23.7 27.5 16.0 24.6 28.2 14.3 19.0 19.9 11.7 9.8 19.6 34.0 41.2 28.1 13.5 21.8 29.8 21.8 10.8 19.5 13.3 29.6 27.9 34.4 16.2 17.1 25.9 20.8 16.0 16.4 24.7 14.8 15.8 15.6 18.7 18.4 23.8 26.0 19.8 6.2 16.3 50.8 15.9 44.5 6.6 27.4 25.2 27.3 21.7 35.0 23.0 20.8 20.4 21.1 33.0 17.1 21.6 22.0 4.2 25.1 27.9 17.3 23.1 13.1 4.9 4.8 12.6 6.7 4.8 4.3 3.4 3.5 3.9 3.2 3.6 6.2 12.2 9.6 7.4 9.1 11.2 25.2 13.9 7.4 4.6 0.0 9.8 9.8 16.7 15.7 9.2 3.7 0.0 13.1 13.9 8.1 19.6 9.6 240.7 9.9 14.8 12.9 4.2 16.6 12.7 9.1 12.0 12.7 7.7 12.5 5.1 18.8 12.5 14.6 14.7 0.0 14.5 15.6 6.1 15.8 13.6 34.3 12.2 10.8 8.8 8.4 14.8 0.0 5.2 4.5 14.4 8.9 5.2 16.6 5.3 14.1 8.7 14.2 8.6 0.0 13.1 14.7 10.8 25.3 19.5 11.4 24.9 11.5 8.8 12.6 18.4 16.6 MYBBP1A "FLJ37886, P160, PAP2, Pol5" ENSG00000132382 "MYB binding protein 1a" Q9BQG0 17 4538897-4555386 "Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Biological rhythms, Ribosome biogenesis, Transcription, Transcription regulation" "Activator, Repressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005466 Supported Supported Nucleoli,Vesicles No No 47000 "Cluster 27: Non-specific - Gene expression" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Nucleoli Vesicles "HPA005466: AB_2667327" "unprognostic (8.06e-2)" "unprognostic (2.33e-1)" "unprognostic (1.71e-1)" "unprognostic (9.01e-2)" "unprognostic (7.81e-2)" "unprognostic (1.29e-1)" "unprognostic (1.57e-3)" "unprognostic (2.22e-1)" "prognostic unfavorable (8.47e-4)" "unprognostic (1.84e-1)" "prognostic favorable (1.61e-4)" "unprognostic (3.88e-3)" "prognostic unfavorable (5.95e-4)" "unprognostic (1.78e-1)" "unprognostic (1.32e-1)" "prognostic unfavorable (8.12e-4)" "unprognostic (9.70e-2)" 12.3 11.0 3.8 13.4 3.8 11.4 15.9 1.3 7.6 13.3 0.8 11.9 9.6 14.6 4.6 17.0 15.2 6.2 11.0 5.0 4.2 9.8 10.8 11.4 13.8 5.2 4.9 14.1 24.4 6.7 12.7 5.2 3.5 17.1 5.1 3.8 18.9 10.1 27.9 22.0 12.9 7.3 2.1 14.0 12.4 8.1 3.4 7.4 11.2 8.0 8.7 14.9 13.8 3.8 60.1 90.0 11.9 56.2 15.4 17.1 40.8 39.8 17.5 39.5 30.8 67.1 24.4 80.4 47.2 23.9 19.8 74.2 50.1 61.3 19.0 40.3 133.8 38.8 58.3 62.2 25.2 45.5 34.7 25.7 34.6 58.8 29.1 11.0 26.6 45.0 64.2 37.1 18.2 51.4 54.2 19.5 56.0 19.1 48.0 69.8 19.7 54.0 9.8 45.5 25.5 48.5 40.8 29.7 28.2 8.6 27.5 19.1 34.3 35.1 31.5 32.7 118.6 32.1 26.5 34.4 32.5 53.9 45.3 0.0 1.9 0.3 2.8 1.6 3.4 2.9 2.3 3.1 2.9 1.7 2.5 2.8 0.1 2.4 3.4 2.1 1.0 2.7 3.8 3.8 1.3 7.6 5.0 4.2 5.2 4.9 3.5 2.1 3.4 3.8 13.4 9.6 14.5 4.6 13.1 12.9 6.8 7.1 12.0 8.2 12.9 14.4 4.1 8.6 13.3 3.7 12.5 2.9 5.8 9.2 0.0 7.7 0.5 6.7 15.3 17.0 11.4 7.2 11.3 12.7 5.4 10.2 10.7 8.5 5.1 12.2 8.6 7.8 6.5 10.1 6.1 8.0 4.1 4.5 6.8 0.6 5.6 6.3 3.6 7.5 3.8 3.8 6.2 3.5 6.5 8.2 4.5 12.0 13.7 13.9 4.6 3.2 12.2 6.2 6.6 10.8 12.9 2.6 11.1 12.8 11.9 1.1 9.7 13.8 12.4 6.2 NME1 "NDPKA, NM23, NM23-H1" ENSG00000239672 "NME/NM23 nucleoside diphosphate kinase 1" P15531 17 51153559-51162428 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Differentiation, Endocytosis, Neurogenesis, Nucleotide metabolism" "Kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008467, CAB040571, HPA041113" Supported Supported "Nucleoplasm,Plasma membrane,Cytosol" "Intracellular and membrane" NA NA 21000000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 77: Retina - Visual perception" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Cytosol "Nucleoplasm, Plasma membrane" "CAB040571: , HPA008467: AB_1079492, HPA041113: AB_2677305" "unprognostic (2.24e-1)" "unprognostic (2.01e-1)" "unprognostic (3.48e-3)" "unprognostic (5.96e-2)" "unprognostic (9.71e-2)" "unprognostic (2.33e-3)" "prognostic unfavorable (2.60e-5)" "unprognostic (4.54e-2)" "unprognostic (3.35e-1)" "unprognostic (2.33e-3)" "unprognostic (2.90e-2)" "unprognostic (1.01e-1)" "prognostic unfavorable (2.07e-9)" "unprognostic (9.01e-2)" "unprognostic (1.51e-1)" "unprognostic (1.83e-1)" "unprognostic (9.46e-2)" 63.6 84.4 79.3 74.7 81.6 77.0 63.1 78.7 102.2 38.2 79.0 60.1 38.8 49.7 46.8 91.0 48.6 20.8 37.7 88.0 92.0 65.4 83.2 41.3 73.9 83.9 78.4 33.6 67.8 52.8 47.4 39.2 82.4 38.7 77.6 218.4 50.7 30.4 35.6 57.5 33.1 66.3 76.5 48.5 41.8 25.3 81.0 61.1 41.3 20.9 95.8 72.2 48.9 80.1 483.6 833.1 285.9 444.8 118.6 183.7 479.7 355.3 227.3 652.2 489.7 656.9 288.1 754.2 372.4 304.1 272.4 252.1 542.5 553.3 553.4 398.4 729.3 504.9 605.8 975.9 237.1 575.8 243.8 177.8 341.7 493.1 458.6 120.6 404.6 247.8 739.0 270.0 392.8 720.4 715.2 647.1 390.7 957.5 739.3 446.9 587.6 751.3 511.5 320.2 418.6 461.1 188.1 521.0 385.3 246.2 554.0 419.6 279.5 476.9 452.2 307.0 774.4 374.0 840.9 956.3 286.2 480.4 385.8 1.1 55.0 2.1 47.2 77.1 69.3 96.4 50.3 53.8 134.0 67.6 54.3 60.4 1.7 69.6 48.6 84.8 49.1 68.4 79.3 81.6 78.7 102.2 88.0 92.0 83.9 78.4 82.4 76.5 81.0 80.1 53.1 32.1 30.5 0.0 71.3 132.4 97.5 198.8 88.8 283.3 98.8 118.1 34.2 65.8 92.3 71.7 285.7 180.0 25.4 54.2 150.6 211.3 34.2 40.2 107.2 85.1 89.7 81.8 0.0 201.5 269.7 85.0 64.2 37.2 45.7 113.5 27.8 123.3 207.1 40.4 0.0 107.4 101.7 25.7 88.9 93.7 61.2 48.9 129.9 0.0 47.2 105.6 27.8 0.0 0.0 194.0 50.5 58.6 113.8 170.6 12.2 195.2 42.0 323.7 13.1 83.0 182.9 22.7 98.8 139.4 133.1 88.5 38.0 215.5 157.7 98.2 NME1-NME2 "NM23-LV, NMELV" ENSG00000011052 "NME1-NME2 readthrough" 17 51153590-51171744 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "retina: 51.2" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 43.5;Basal keratinocytes: 38.4;Basal respiratory cells: 23.3;Club cells: 31.1;granulocytes: 22.7;Langerhans cells: 35.0;Melanocytes: 23.2;Suprabasal keratinocytes: 51.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002169, HPA008467, HPA041113, CAB076057" Approved Approved Cytosol NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 77: Retina - Visual perception" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 11: Alveolar cells - Smell perception" Cytosol "CAB002169: AB_563917, CAB076057: , HPA008467: AB_1079492, HPA041113: AB_2677305" "unprognostic (2.39e-1)" "unprognostic (5.29e-2)" "unprognostic (9.70e-2)" "unprognostic (5.13e-2)" "prognostic favorable (6.66e-4)" "unprognostic (2.46e-2)" "unprognostic (4.82e-3)" "unprognostic (8.39e-2)" "unprognostic (2.30e-2)" "unprognostic (1.53e-1)" "unprognostic (4.58e-6)" "unprognostic (1.03e-1)" "unprognostic (2.74e-6)" "unprognostic (1.84e-1)" "unprognostic (9.72e-2)" "unprognostic (1.50e-1)" "unprognostic (1.43e-3)" 12.3 21.0 7.2 15.1 7.4 10.9 8.7 6.5 10.3 8.7 6.3 6.7 3.6 9.3 0.8 14.7 9.4 2.2 9.9 8.7 6.8 12.4 16.4 9.2 8.7 7.8 6.7 5.6 16.6 6.4 11.9 7.1 7.8 6.8 2.9 51.2 13.8 2.2 12.9 12.2 4.9 6.8 6.5 7.9 9.0 3.0 7.7 6.2 7.4 3.6 3.7 13.1 9.9 7.3 22.4 5.5 21.2 48.3 27.9 13.1 7.7 32.3 20.8 15.9 9.5 11.1 8.6 30.1 34.3 41.3 33.2 21.9 25.1 44.7 8.8 51.0 46.6 15.2 9.1 22.7 30.5 25.5 42.2 25.4 36.2 21.2 31.4 49.6 28.0 38.8 21.2 36.7 12.3 14.6 141.2 37.4 19.6 66.5 9.5 49.5 21.0 85.0 23.0 9.4 70.1 56.4 13.9 112.7 38.3 37.8 87.8 86.3 34.1 57.0 14.6 76.8 26.2 60.8 52.2 41.4 26.7 24.6 46.4 0.4 16.0 0.7 18.2 24.1 26.9 14.1 15.7 17.1 45.9 23.4 13.9 16.9 1.7 14.4 11.9 28.4 16.9 20.8 7.2 7.4 6.5 10.3 8.7 6.8 7.8 6.7 7.8 6.5 7.7 7.3 0.0 16.0 43.5 0.0 1.5 38.4 0.0 23.3 2.2 0.0 0.0 0.0 2.2 0.0 31.1 0.0 0.0 0.0 0.1 8.0 0.0 0.0 0.0 0.2 0.2 5.1 1.8 0.4 3.9 0.0 0.1 12.1 1.5 0.2 22.7 0.1 0.4 0.6 0.0 0.0 3.5 7.2 10.2 0.0 35.0 0.0 0.3 6.8 23.2 0.0 0.0 0.0 0.0 2.0 0.9 0.0 1.1 0.0 2.0 0.0 0.0 0.1 16.3 0.0 0.0 0.0 16.4 0.1 0.0 3.8 51.9 0.0 3.0 0.0 7.8 0.1 NME2 "NDPKB, NM23-H2" ENSG00000243678 "NME/NM23 nucleoside diphosphate kinase 2" P22392 17 51165435-51171744 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Nucleotide metabolism, Transcription, Transcription regulation" "Activator, DNA-binding, Kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 918.0;Gastric mucus-secreting cells: 438.3;Plasma cells: 778.5;Squamous epithelial cells: 1490.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected" "Not detected" "CAB036213, CAB036214, CAB036215, HPA041113" Approved Supported "Plasma membrane,Midbody ring,Cytosol" Yes NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 50: Non-specific - Ribosome" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 61: Squamous epithelial cells - Keratinization" Cytosol "Plasma membrane, Midbody ring" "CAB036213: , CAB036214: , CAB036215: , HPA041113: AB_2677305" "unprognostic (7.21e-3)" "prognostic unfavorable (4.74e-4)" "unprognostic (4.85e-2)" "unprognostic (1.15e-2)" "unprognostic (8.86e-2)" "unprognostic (1.42e-2)" "prognostic unfavorable (7.09e-4)" "unprognostic (6.62e-3)" "unprognostic (5.68e-2)" "unprognostic (2.31e-1)" "unprognostic (1.38e-1)" "unprognostic (6.41e-2)" "prognostic unfavorable (1.55e-6)" "unprognostic (2.82e-1)" "unprognostic (9.09e-2)" "unprognostic (8.87e-2)" "unprognostic (3.19e-2)" 503.5 428.3 308.0 259.5 319.0 329.4 489.1 328.0 379.9 439.2 431.1 409.2 335.1 383.4 236.1 610.6 350.6 187.0 403.9 313.7 338.6 478.1 428.4 339.6 288.9 326.6 320.7 500.1 632.0 201.8 234.9 204.8 321.3 367.7 330.4 63.3 432.4 247.5 545.7 540.3 307.6 286.2 326.8 336.0 403.5 77.8 333.3 190.0 305.3 353.7 289.1 463.5 464.2 333.4 1638.6 2233.9 466.1 913.7 969.3 1399.2 1449.2 1091.7 954.0 1404.8 1053.5 1789.7 792.3 1314.3 1662.9 913.0 706.6 956.2 947.3 1273.3 1035.7 1604.8 3283.2 1120.3 1345.8 2513.4 1116.1 1736.0 760.5 1324.1 1420.0 901.9 1466.4 914.6 860.9 856.5 1541.7 773.7 956.1 2741.9 931.3 2144.8 831.4 2974.6 3364.2 875.9 1731.8 2157.2 1417.9 1800.2 1160.6 641.9 674.1 1472.7 1583.0 806.1 1201.7 1268.5 1013.5 1462.8 1158.2 1135.2 1774.8 1520.9 2176.6 1558.1 815.1 919.1 819.2 66.8 243.4 14.0 166.7 325.5 235.6 338.9 211.9 183.3 439.5 259.2 153.5 170.0 13.8 251.6 282.5 478.1 211.2 298.2 308.0 319.0 328.0 379.9 313.7 338.6 326.6 320.7 321.3 326.8 333.3 333.4 9.7 28.9 67.2 0.0 146.8 14.5 8.3 10.8 918.0 0.9 41.6 35.9 0.0 22.8 85.7 5.5 0.0 10.0 10.1 7.1 37.2 47.4 0.6 16.4 34.3 60.9 14.6 298.2 0.0 34.5 27.8 99.0 438.3 21.3 42.9 6.8 22.9 37.6 16.4 0.0 0.0 19.3 8.2 34.8 17.4 2.1 25.7 136.7 10.6 0.0 55.5 0.4 2.1 0.0 0.0 40.7 15.6 12.8 778.5 7.6 11.7 33.8 63.6 0.8 6.6 10.2 43.3 0.6 5.6 1490.1 14.9 8.8 87.0 6.8 25.0 11.0 NME3 "DR-nm23, NDPKC, NM23-H3" ENSG00000103024 "NME/NM23 nucleoside diphosphate kinase 3" Q13232 16 1770286-1771730 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Nucleotide metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HEK 293: 70.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041113, HPA052733" Approved Approved Nucleoplasm,Cytosol "Intracellular and membrane" NA NA 12000000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 72: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm Cytosol "HPA041113: AB_2677305, HPA052733: AB_2681930" "prognostic favorable (6.81e-5)" "unprognostic (1.41e-1)" "unprognostic (1.49e-1)" "unprognostic (1.15e-3)" "unprognostic (1.26e-1)" "unprognostic (1.61e-1)" "unprognostic (1.05e-1)" "unprognostic (4.54e-2)" "unprognostic (1.13e-1)" "unprognostic (6.22e-3)" "unprognostic (4.40e-2)" "unprognostic (4.43e-2)" "unprognostic (7.09e-3)" "unprognostic (1.79e-1)" "unprognostic (3.84e-1)" "unprognostic (3.64e-1)" "unprognostic (6.11e-3)" 34.0 84.4 21.3 8.0 22.7 3.9 34.2 21.0 36.3 41.9 16.8 47.7 15.9 36.7 3.4 27.2 44.3 2.1 36.0 20.2 23.1 44.6 36.3 29.1 5.4 23.7 22.2 43.7 37.2 4.5 71.9 5.2 19.6 59.4 3.1 1.8 35.9 13.0 17.1 31.1 33.8 3.2 22.5 39.4 38.6 16.0 22.0 1.0 40.3 3.1 1.9 38.5 33.5 24.9 1.6 26.9 0.6 21.8 6.1 3.2 2.5 15.7 4.5 2.7 2.1 0.0 31.8 0.4 42.6 2.2 2.8 23.0 1.3 8.8 0.3 32.1 70.9 0.0 12.0 13.0 11.3 5.5 9.8 14.0 7.9 2.7 1.5 5.1 5.6 0.2 11.2 4.4 2.7 40.4 0.4 10.8 28.0 5.4 21.5 15.3 0.3 43.5 4.5 1.2 30.6 23.6 47.1 35.2 4.2 1.2 33.7 13.1 19.9 5.8 21.4 18.5 10.8 11.1 3.7 2.5 8.1 0.9 13.3 10.0 50.7 34.6 33.3 49.6 32.9 36.8 46.3 31.4 45.1 31.9 39.6 31.3 10.8 44.8 55.4 70.3 45.4 41.3 21.3 22.7 21.0 36.3 20.2 23.1 23.7 22.2 19.6 22.5 22.0 24.9 128.8 35.3 62.7 69.9 64.6 72.5 141.3 97.7 179.8 116.3 147.3 165.6 28.0 90.1 76.6 126.9 60.5 86.6 77.9 76.2 60.7 62.9 22.1 66.5 102.9 84.1 135.5 25.7 34.6 37.6 46.3 100.9 76.0 77.6 50.8 71.6 99.9 63.0 74.8 65.6 30.2 109.4 50.8 60.3 91.0 20.3 149.5 71.1 81.8 29.0 136.5 126.9 77.2 40.7 63.7 37.0 104.7 127.5 93.1 98.4 157.2 150.2 70.9 126.7 118.3 75.9 100.8 2.0 40.4 100.9 65.6 46.1 87.3 183.8 107.6 100.6 NME4 "NDPKD, nm23-H4, NM23H4" ENSG00000103202 "NME/NM23 nucleoside diphosphate kinase 4" O00746 16 396725-410367 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Lipid transport, Nucleotide metabolism, Transport" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal tubular cells: 250.5;Erythroid cells: 311.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB045997, HPA072588" Approved Supported Mitochondria Yes No "Cluster 26: Non-specific - Mitochondria" "Cluster 15: Liver - Metabolism" "Cluster 14: REH - Unknown function" "Cluster 33: Fibroblasts - ECM organization" Mitochondria "CAB045997: AB_11126630, HPA072588: AB_2686538" "unprognostic (3.27e-1)" "prognostic unfavorable (6.53e-4)" "unprognostic (3.70e-2)" "unprognostic (7.16e-3)" "unprognostic (1.32e-1)" "unprognostic (2.00e-1)" "unprognostic (4.40e-2)" "unprognostic (4.46e-3)" "unprognostic (1.98e-1)" "unprognostic (3.12e-1)" "unprognostic (3.74e-2)" "unprognostic (7.79e-3)" "prognostic unfavorable (1.61e-7)" "unprognostic (3.78e-2)" "unprognostic (2.16e-1)" "unprognostic (6.04e-2)" "unprognostic (3.08e-1)" 89.3 136.1 78.3 26.2 75.6 127.7 72.9 73.5 101.5 88.1 77.3 192.9 21.9 79.5 55.7 50.1 89.1 41.2 101.2 76.4 81.7 60.4 175.2 48.3 21.1 88.6 77.9 86.8 43.7 56.7 64.3 30.8 79.8 143.7 23.5 11.1 70.4 81.9 34.7 31.4 59.7 51.9 78.6 43.8 97.7 44.7 80.3 29.3 51.6 27.2 15.8 145.6 64.3 73.6 1.0 305.4 265.6 366.7 104.0 181.0 59.5 143.6 170.4 211.8 180.6 205.4 176.2 3.0 105.8 230.2 76.9 3.9 145.0 153.9 62.0 126.5 218.7 151.9 40.2 279.9 195.7 111.0 53.1 234.7 79.8 130.5 12.8 152.2 137.6 210.7 159.6 25.8 160.4 255.4 98.5 139.2 271.8 76.1 67.8 485.8 59.3 79.0 150.6 1.2 77.7 419.2 36.8 2.7 139.9 97.2 178.3 257.5 174.0 149.7 216.8 101.8 36.8 2.7 2.0 83.1 65.8 19.8 177.2 12.9 13.3 39.8 14.9 11.9 12.7 27.6 14.4 16.3 17.6 29.9 26.0 13.4 4.2 2.5 10.6 58.3 0.9 10.7 78.3 75.6 73.5 101.5 76.4 81.7 88.6 77.9 79.8 78.6 80.3 73.6 52.2 0.0 13.9 18.6 40.6 32.2 56.3 49.0 40.9 15.2 116.6 135.8 44.5 52.9 25.1 58.8 2.1 71.7 45.7 19.3 250.5 116.5 5.0 30.8 113.3 55.3 45.1 311.8 16.8 40.3 26.1 87.3 29.6 59.8 29.9 199.9 55.6 132.2 131.2 8.4 21.1 38.6 26.4 46.5 68.6 21.6 89.2 35.4 62.2 10.3 46.5 45.9 19.6 10.1 3.6 58.3 23.8 94.8 34.5 121.8 9.0 75.5 7.9 5.6 52.6 40.1 105.8 1.7 32.7 38.6 24.6 21.8 26.2 89.4 54.9 60.9 NME5 "nm23-H5, RSPH23" ENSG00000112981 "NME/NM23 family member 5" P56597 5 138115175-138139443 "Metabolic proteins, Predicted intracellular proteins" "Differentiation, Spermatogenesis" "Developmental protein" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "fallopian tube: 37.2;testis: 53.3" "Group enriched" "Detected in many" 4 "Early spermatids: 704.9;Endometrial ciliated cells: 205.8;Late spermatids: 256.5;Respiratory ciliated cells: 431.9;Spermatocytes: 326.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "RPTEC TERT1: 29.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035648, HPA044555, HPA058103" Enhanced Approved "Nucleoplasm,Nuclear bodies" Yes NA "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 49: Ciliated cells - Cilium organization" "Nucleoplasm, Nuclear bodies" "HPA035648: AB_2674719, HPA044555: AB_10960286, HPA058103: " "unprognostic (2.49e-2)" "unprognostic (7.63e-4)" "unprognostic (9.97e-2)" "prognostic favorable (7.24e-5)" "unprognostic (3.27e-2)" "unprognostic (2.27e-1)" "unprognostic (3.04e-3)" "unprognostic (3.06e-1)" "unprognostic (1.34e-1)" "unprognostic (2.39e-2)" "unprognostic (1.83e-2)" "unprognostic (2.14e-1)" "prognostic favorable (1.76e-4)" "unprognostic (9.14e-4)" "unprognostic (1.11e-3)" "unprognostic (3.45e-1)" "unprognostic (3.16e-2)" 1.4 6.5 9.7 0.5 10.5 0.0 4.5 9.2 11.7 8.6 18.6 2.1 0.2 4.9 23.1 1.0 37.2 8.7 3.6 10.5 9.2 20.5 0.5 4.5 0.4 10.5 12.3 5.3 4.4 24.3 8.9 0.1 12.1 5.0 1.1 12.9 3.7 4.5 0.4 0.3 0.6 3.1 9.6 0.2 2.8 53.3 11.0 0.7 12.4 0.6 0.2 2.1 0.6 8.9 0.0 0.0 3.9 4.3 0.0 0.0 0.0 0.7 0.4 0.7 0.3 0.1 1.8 0.0 1.1 0.1 0.7 0.0 0.0 0.0 0.2 0.0 0.9 0.0 0.0 0.0 1.7 0.0 0.0 2.1 0.0 0.9 0.0 3.8 0.4 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.6 0.0 1.4 0.0 0.0 0.0 29.9 0.0 6.7 2.5 0.0 0.8 4.9 1.7 0.5 1.6 0.0 0.7 0.0 0.0 0.9 0.4 0.8 0.0 5.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.7 10.5 9.2 11.7 10.5 9.2 10.5 12.3 12.1 9.6 11.0 8.9 1.0 6.4 7.5 26.8 0.3 0.6 8.5 41.1 0.0 11.7 9.0 7.9 4.3 8.6 38.1 33.1 14.6 0.5 0.1 0.3 86.1 23.8 704.9 205.8 9.2 3.5 5.4 0.0 57.9 4.0 0.0 4.2 2.6 12.7 0.0 7.7 3.6 0.6 0.1 6.7 42.2 3.3 44.7 0.0 0.3 256.5 9.0 1.4 10.6 3.7 0.6 19.1 0.0 11.1 8.1 4.2 0.3 13.9 0.0 4.8 0.2 92.3 431.9 25.8 0.0 0.5 12.6 326.8 24.7 0.0 0.3 0.0 0.8 10.9 1.7 5.9 NME6 "IPIA-ALPHA, NM23-H6" ENSG00000172113 "NME/NM23 nucleoside diphosphate kinase 6" O75414 3 48290722-48301685 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Nucleotide metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017909 Approved Approved Vesicles NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" Vesicles "HPA017909: AB_1854530" "unprognostic (7.31e-3)" "unprognostic (1.87e-1)" "unprognostic (8.19e-3)" "unprognostic (2.09e-2)" "unprognostic (8.52e-2)" "unprognostic (2.20e-1)" "prognostic unfavorable (2.17e-7)" "unprognostic (1.90e-1)" "unprognostic (1.56e-1)" "unprognostic (4.00e-3)" "unprognostic (1.32e-1)" "unprognostic (2.98e-1)" "prognostic favorable (3.18e-5)" "unprognostic (1.98e-2)" "unprognostic (1.57e-2)" "unprognostic (1.23e-1)" "unprognostic (9.50e-2)" 8.7 7.7 6.3 10.4 6.4 8.1 12.1 9.2 6.3 10.2 8.7 11.6 13.2 9.3 8.5 12.1 14.8 8.9 13.5 7.1 6.5 11.1 10.3 10.2 12.2 5.9 6.3 12.4 11.6 12.4 6.0 14.2 5.7 9.5 11.5 7.6 10.9 8.7 17.7 10.0 10.4 12.4 4.9 9.6 11.5 6.2 6.4 9.4 12.2 17.2 13.7 9.6 9.0 6.3 30.0 19.1 24.3 18.3 18.2 23.4 22.1 27.2 18.3 37.5 27.3 30.5 26.5 30.1 14.0 20.5 36.5 10.1 21.9 27.2 24.1 36.1 21.3 17.9 24.1 26.6 25.7 24.3 20.7 19.7 33.8 34.4 42.9 19.3 19.8 21.1 33.9 23.6 14.0 13.9 21.4 11.3 22.3 19.5 23.3 12.7 22.9 25.3 21.2 23.6 7.7 12.7 19.8 21.0 26.1 17.8 23.9 22.5 22.1 8.3 33.0 21.2 39.4 27.0 40.9 26.1 16.3 31.9 18.4 47.3 33.4 76.4 40.9 36.0 36.6 43.5 37.4 35.2 39.9 38.0 28.1 27.2 37.3 40.4 42.1 34.5 33.5 25.1 6.3 6.4 9.2 6.3 7.1 6.5 5.9 6.3 5.7 4.9 6.4 6.3 13.1 28.9 20.7 2.3 16.4 5.0 8.5 18.2 9.6 11.9 14.1 13.6 10.4 15.7 19.4 9.2 14.6 49.5 18.4 8.2 39.2 24.8 2.6 16.1 17.5 12.8 4.2 8.0 2.5 30.1 41.6 12.4 11.7 11.8 10.1 22.8 7.9 7.9 34.4 10.1 3.2 10.8 12.2 9.3 9.7 1.7 11.8 13.7 16.0 1.9 23.4 17.6 18.6 2.5 2.7 31.3 8.3 7.2 10.8 12.8 16.6 16.4 30.6 11.5 13.1 7.7 12.2 9.3 15.0 12.4 4.1 19.7 14.7 15.1 12.8 7.1 NME7 "CFAP67, FLJ37194, NM23-H7" ENSG00000143156 "NME/NM23 family member 7" Q9Y5B8 1 169132531-169367948 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Nucleotide metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 274.9;Inhibitory neurons: 307.2;Oligodendrocytes: 277.7;Respiratory ciliated cells: 142.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028334, HPA038014, HPA054289" Approved Approved Nucleoplasm NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA028334: , HPA038014: AB_10673037, HPA054289: AB_2682437" "unprognostic (1.28e-1)" "unprognostic (8.52e-2)" "unprognostic (6.21e-2)" "unprognostic (6.30e-2)" "unprognostic (1.11e-1)" "unprognostic (7.44e-3)" "prognostic unfavorable (3.24e-5)" "unprognostic (1.42e-1)" "unprognostic (1.96e-1)" "unprognostic (2.90e-1)" "unprognostic (1.05e-1)" "unprognostic (2.00e-1)" "unprognostic (6.63e-2)" "unprognostic (2.67e-2)" "unprognostic (1.12e-1)" "unprognostic (7.75e-2)" "unprognostic (2.74e-1)" 6.7 10.6 9.4 5.5 9.9 3.5 11.1 8.4 12.2 13.0 11.8 9.8 3.9 12.9 13.3 7.5 27.7 10.0 6.2 10.8 10.8 12.5 7.9 7.6 5.6 10.2 10.0 13.6 7.2 18.3 14.2 4.8 9.9 8.0 5.6 20.7 4.3 11.5 4.1 4.0 4.6 14.9 9.3 4.4 5.8 16.0 9.9 11.1 13.6 4.9 6.4 8.8 6.2 9.6 24.3 23.6 26.4 20.9 25.1 26.1 9.4 16.6 24.2 28.5 35.8 13.8 33.7 7.1 29.4 14.5 38.8 16.2 15.6 35.3 46.1 25.5 12.3 12.5 21.3 14.1 18.5 23.8 8.3 18.8 20.1 29.5 38.3 39.2 40.8 21.1 12.6 9.5 28.8 7.1 22.7 16.8 26.5 27.4 25.2 16.1 29.4 15.3 46.0 7.3 27.5 40.6 23.0 7.6 18.4 28.3 24.4 16.4 25.4 17.4 59.5 16.5 40.2 11.7 21.3 14.8 19.8 8.2 17.8 1.6 3.9 2.1 9.6 6.3 11.6 9.9 12.0 9.9 6.3 9.3 10.1 11.7 1.1 11.4 9.8 5.1 14.9 5.3 9.4 9.9 8.4 12.2 10.8 10.8 10.2 10.0 9.9 9.3 9.9 9.6 12.3 6.4 10.9 97.6 9.0 14.4 34.5 61.9 15.4 18.9 13.7 14.7 5.1 20.0 29.3 27.6 25.0 7.6 9.2 2.1 23.5 26.6 43.2 75.7 20.4 12.8 17.5 13.7 274.9 8.9 7.4 21.1 12.8 22.2 21.5 21.8 13.9 11.2 14.6 28.6 307.2 4.1 36.7 4.1 11.9 13.8 18.0 6.5 8.8 64.6 3.3 23.8 10.3 106.1 277.7 16.9 6.0 20.7 7.2 8.6 4.9 40.9 142.9 64.9 19.7 21.2 24.7 67.7 21.9 9.2 10.2 2.7 18.7 26.4 6.0 16.5 NT5C "cdN, DNT-1, DNT1, PN-I, UMPH2" ENSG00000125458 "5', 3'-nucleotidase, cytosolic" Q8TCD5 17 75130225-75131757 "Metabolic proteins, Predicted intracellular proteins" "Nucleotide metabolism" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA021581, HPA023632" Approved Supported Cytosol NA NA 760000 "Cluster 10: Basophils - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "HPA021581: AB_1854663, HPA023632: AB_1854662" "unprognostic (3.83e-2)" "unprognostic (4.45e-2)" "unprognostic (2.39e-1)" "unprognostic (3.61e-2)" "unprognostic (1.26e-1)" "unprognostic (9.21e-2)" "prognostic unfavorable (3.05e-4)" "unprognostic (1.26e-1)" "unprognostic (7.25e-2)" "unprognostic (8.26e-3)" "unprognostic (7.15e-2)" "unprognostic (2.22e-1)" "unprognostic (6.57e-2)" "unprognostic (1.58e-1)" "unprognostic (1.10e-1)" "unprognostic (2.13e-1)" "prognostic favorable (7.66e-4)" 31.6 31.4 14.5 17.9 15.9 16.3 31.8 16.5 17.4 37.0 14.8 43.0 24.5 34.7 5.2 45.9 32.1 8.4 32.6 14.1 16.7 47.8 29.1 29.2 18.3 17.1 15.5 37.5 33.7 11.7 18.9 10.2 15.6 35.7 13.1 8.7 25.8 15.3 41.1 33.8 43.7 7.6 16.6 40.7 36.8 15.2 15.5 16.0 37.7 16.1 15.2 37.9 35.9 18.4 52.5 77.7 25.3 26.5 7.5 15.4 33.7 29.5 26.2 29.7 18.8 29.5 58.3 35.5 21.5 21.0 5.2 33.7 18.1 37.7 16.5 16.1 51.3 40.5 68.7 50.0 38.0 38.8 17.2 23.1 17.4 21.3 57.0 11.9 33.0 27.6 38.4 16.8 30.2 51.2 28.0 39.0 26.5 43.6 50.6 24.9 32.9 50.9 39.3 26.7 30.0 60.1 28.3 34.8 43.9 14.0 49.8 27.2 20.4 25.0 62.1 9.8 40.3 33.3 5.6 41.1 23.8 23.3 40.4 183.7 29.7 48.9 39.2 49.6 27.7 94.9 25.5 33.6 37.9 87.4 21.6 33.5 14.4 72.6 50.7 50.4 45.2 30.2 14.5 15.9 16.5 17.4 14.1 16.7 17.1 15.5 15.6 16.6 15.5 18.4 23.0 32.1 19.5 22.2 132.9 47.4 86.1 108.8 90.5 66.0 58.8 101.9 16.4 77.2 35.2 58.8 20.9 64.9 85.8 272.8 78.2 102.2 2.1 53.2 53.5 26.6 64.1 59.5 7.7 121.4 100.4 59.8 181.5 43.2 46.3 59.0 11.7 41.9 74.5 42.1 8.0 133.4 52.9 55.7 64.4 6.8 59.4 56.2 58.7 18.7 108.4 55.9 98.9 19.6 19.2 127.5 221.6 47.4 51.2 115.8 231.6 144.2 31.1 65.5 32.9 39.0 107.6 19.0 49.6 89.4 44.3 31.2 67.4 98.4 152.8 85.9 NT5C1A "CN-I, CN-IA, CN1, CN1A, MGC119199, MGC119201" ENSG00000116981 "5'-nucleotidase, cytosolic IA" Q9BXI3 1 39659121-39672038 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Nucleotide metabolism" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "skeletal muscle: 72.4;tongue: 28.6" "Cell type enhanced" "Detected in single" "Inhibitory neurons: 1.2" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 12 "SH-SY5Y: 17.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA050283, HPA054158" Supported NA NA "Cluster 33: Striated muscle - Muscle contraction" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA050283: AB_2681072, HPA054158: AB_2682402" "unprognostic (7.85e-2)" "unprognostic (1.60e-1)" "unprognostic (6.19e-1)" "unprognostic (1.51e-3)" "unprognostic (7.19e-2)" "unprognostic (2.87e-1)" "unprognostic (3.34e-1)" "unprognostic (1.32e-1)" "unprognostic (3.29e-2)" "unprognostic (1.81e-2)" 0.2 2.6 1.4 0.1 0.8 0.0 0.0 4.8 5.4 0.2 0.0 0.0 0.0 0.1 0.1 3.0 0.2 0.0 11.4 0.7 1.6 0.4 0.0 0.0 0.0 3.0 3.1 0.1 3.9 0.0 0.0 0.0 2.0 0.5 0.0 0.1 0.1 0.1 72.4 0.0 0.1 0.1 1.4 0.0 0.1 0.2 2.2 0.1 0.0 28.6 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 17.8 0.0 0.0 0.3 0.0 0.0 1.4 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.8 4.8 5.4 0.7 1.6 3.0 3.1 2.0 1.4 2.2 1.1 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 NT5C1B "AIRP, CN-IB" ENSG00000185013 "5'-nucleotidase, cytosolic IB" Q96P26 2 18562872-18589572 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Nucleotide metabolism" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 13 "testis: 35.5" "Group enriched" "Detected in some" 29 "Early spermatids: 159.5;Late spermatids: 300.4" "Not detected" "Not detected" "Not detected" "Not detected" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in some" HPA056683 Uncertain Approved "Nucleoplasm,Nucleoli,Plasma membrane" NA NA "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 83: Testis - Spermatogenesis" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoli, Plasma membrane" Nucleoplasm "HPA056683: AB_2683207" "unprognostic (4.18e-2)" "unprognostic (1.20e-2)" "unprognostic (7.67e-2)" "unprognostic (1.31e-1)" "unprognostic (1.02e-1)" "unprognostic (4.97e-2)" "unprognostic (4.96e-2)" "unprognostic (4.84e-1)" "unprognostic (8.49e-2)" "unprognostic (4.42e-2)" "unprognostic (2.91e-2)" "unprognostic (2.35e-1)" "unprognostic (1.61e-1)" "unprognostic (6.96e-2)" "unprognostic (2.50e-1)" "unprognostic (1.15e-1)" "unprognostic (3.77e-1)" 0.1 0.5 0.2 0.2 0.3 0.4 0.1 0.2 0.2 0.1 2.6 0.1 0.7 0.1 0.0 1.0 0.1 0.7 0.6 0.1 0.1 0.3 0.2 0.2 0.3 0.3 0.5 0.0 0.4 0.0 0.1 0.2 0.2 0.2 0.0 0.1 0.2 0.0 0.0 1.1 0.2 0.0 0.1 0.2 0.8 35.5 0.4 0.0 0.7 0.0 0.0 0.3 0.1 0.2 1.2 0.2 0.1 0.0 0.0 0.0 0.1 0.9 0.0 0.0 0.0 0.0 1.2 0.5 0.1 0.0 0.7 0.3 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.3 0.0 0.2 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.2 0.4 0.1 0.0 1.0 0.0 0.1 0.2 0.2 0.6 0.1 0.2 0.3 0.0 1.1 0.8 0.4 0.9 0.1 0.5 0.1 0.2 0.2 0.6 0.5 0.3 1.0 0.1 0.3 0.2 0.7 0.9 0.0 0.4 0.0 0.0 0.0 0.4 0.0 0.7 0.0 0.4 0.4 0.1 0.3 0.8 0.7 0.0 0.2 0.0 1.2 0.1 0.1 0.2 0.3 0.2 0.2 0.1 0.1 0.3 0.5 0.2 0.1 0.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 159.5 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 300.4 2.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.7 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 NT5C1B-RDH14 ENSG00000250741 "NT5C1B-RDH14 readthrough" 2 18555545-18589564 "Metabolic proteins, Predicted intracellular proteins" "Evidence at transcript level" "Evidence at transcript level" "Tissue enriched" "Detected in single" 126 "testis: 16.6" "Group enriched" "Detected in some" 97 "Early spermatids: 52.3;Late spermatids: 64.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA056683 Uncertain Approved "Nucleoplasm,Nucleoli,Plasma membrane" NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 34: Spermatids - Unknown function" "Nucleoli, Plasma membrane" Nucleoplasm "HPA056683: AB_2683207" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 16.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 52.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 64.8 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 NT5C2 "cN-II, GMP, NT5B, PNT5, SPG45, SPG65" ENSG00000076685 "5'-nucleotidase, cytosolic II" P49902 10 103087185-103277605 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Nucleotide metabolism" "Allosteric enzyme, Hydrolase" "Cancer-related genes, Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 141.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003751 Approved NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 22: Epithelial cell types - Mixed function" "HPA003751: AB_1854664" "unprognostic (8.18e-2)" "unprognostic (1.98e-1)" "unprognostic (2.55e-2)" "unprognostic (2.46e-1)" "unprognostic (5.54e-2)" "unprognostic (4.87e-3)" "unprognostic (2.24e-2)" "unprognostic (1.72e-1)" "unprognostic (6.41e-2)" "unprognostic (9.59e-2)" "unprognostic (2.93e-3)" "unprognostic (6.20e-2)" "unprognostic (3.26e-2)" "unprognostic (3.70e-2)" "unprognostic (6.40e-2)" "unprognostic (3.43e-1)" "unprognostic (1.50e-1)" 24.6 27.0 25.0 19.0 27.2 29.7 23.0 27.3 28.5 37.6 36.8 27.3 9.9 18.8 17.3 67.1 26.5 16.4 28.5 25.2 28.8 32.5 27.8 30.8 18.3 26.9 29.5 32.4 22.0 21.7 34.0 17.9 27.2 32.4 16.7 47.3 46.4 18.4 51.6 19.9 20.4 13.4 26.4 32.8 22.3 30.8 27.2 28.6 55.4 18.1 24.5 33.3 42.7 28.6 148.4 52.5 32.6 67.5 27.2 33.2 18.2 66.0 64.7 29.9 32.4 34.6 91.7 49.2 47.7 45.6 27.6 62.8 23.4 33.8 38.3 40.3 21.6 38.7 21.1 39.6 48.5 64.2 21.0 50.4 34.1 28.0 24.8 57.5 25.6 19.4 29.4 36.4 54.5 73.8 53.7 64.6 34.6 43.2 68.6 102.6 30.0 19.6 43.3 72.5 10.0 24.9 35.8 25.9 50.3 33.7 39.2 38.1 30.5 20.5 24.8 39.7 51.7 32.9 71.6 85.5 23.9 64.6 7.8 29.5 16.5 31.3 10.0 18.8 10.3 8.9 8.4 8.7 14.7 5.2 6.7 8.0 27.4 14.4 23.0 9.6 9.3 10.5 25.0 27.2 27.3 28.5 25.2 28.8 26.9 29.5 27.2 26.4 27.2 28.6 16.2 83.3 34.9 141.7 17.2 7.4 29.0 26.9 5.7 24.4 13.9 13.6 2.6 18.6 60.4 27.6 45.9 19.4 23.3 48.7 11.7 28.5 103.7 29.5 17.1 19.8 11.5 12.4 79.8 26.0 11.7 17.5 25.5 46.2 8.8 18.2 13.9 17.4 19.9 47.1 83.6 17.6 18.3 29.8 14.2 61.9 24.8 27.1 26.6 78.7 25.9 85.5 16.5 70.4 107.5 57.9 23.1 13.5 21.0 35.7 11.7 15.3 44.1 59.1 32.9 22.9 21.7 25.3 20.5 22.9 7.5 35.0 16.6 15.8 18.0 80.5 NT5C3A "cN-III, hUMP1, NT5C3, p36, P5'N-1, PN-I, POMP, PSN1, UMPH, UMPH1" ENSG00000122643 "5'-nucleotidase, cytosolic IIIA" Q9H0P0 7 33014114-33062797 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Nucleotide metabolism" "Hydrolase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 87.4" "Cell type enhanced" "Detected in all" "Distal enterocytes: 191.0;Paneth cells: 186.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA010520, HPA010630, HPA029058" Uncertain Supported "Nucleoplasm,Nuclear bodies,Endoplasmic reticulum,Cytosol" "Intracellular and membrane" NA NA 10000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 51: Myeloid cells - Hemostasis" "Endoplasmic reticulum, Cytosol" "Nucleoplasm, Nuclear bodies" "HPA010520: , HPA010630: AB_2668319, HPA029058: AB_10601380" "unprognostic (7.50e-2)" "unprognostic (3.10e-1)" "unprognostic (1.14e-1)" "unprognostic (2.69e-2)" "unprognostic (1.22e-1)" "unprognostic (5.56e-2)" "prognostic unfavorable (2.42e-4)" "unprognostic (3.25e-2)" "unprognostic (3.12e-2)" "unprognostic (2.82e-3)" "unprognostic (2.08e-2)" "unprognostic (1.98e-1)" "prognostic unfavorable (1.70e-4)" "unprognostic (9.37e-2)" "unprognostic (2.05e-1)" "unprognostic (2.12e-3)" "unprognostic (3.43e-3)" 12.4 14.3 11.4 26.1 11.4 32.6 21.3 15.2 15.6 12.6 10.8 51.9 40.0 16.9 14.3 18.6 15.9 23.4 16.6 11.5 11.5 22.4 11.8 17.6 30.8 11.1 11.8 13.4 21.4 9.7 7.5 16.3 11.5 12.3 51.0 20.4 9.7 10.0 87.4 28.7 37.3 13.2 12.7 22.9 27.0 9.5 12.0 22.5 17.1 51.0 45.8 23.8 14.4 13.1 42.2 27.6 25.2 29.6 21.2 16.1 20.3 44.8 30.5 29.2 38.9 19.9 115.1 100.4 27.7 29.6 48.3 63.8 28.3 30.8 40.4 16.2 36.2 54.7 36.5 28.7 23.3 55.6 36.9 21.7 23.8 35.9 63.0 16.4 22.2 33.2 43.3 24.8 37.3 29.9 25.0 87.8 27.8 47.1 31.2 25.9 22.9 60.0 87.8 39.8 28.1 37.0 31.1 52.4 66.6 24.5 35.2 33.5 19.8 25.1 20.9 42.6 55.7 50.6 69.0 54.8 20.6 34.9 42.5 112.5 25.9 82.5 26.6 32.7 30.6 64.0 34.2 30.8 22.1 63.6 34.5 29.1 103.8 28.2 39.2 20.6 56.2 37.9 11.4 11.4 15.2 15.6 11.5 11.5 11.1 11.8 11.5 12.7 12.0 13.1 39.1 22.4 13.7 30.7 85.1 46.8 40.9 85.3 47.8 23.9 22.6 18.9 16.9 32.9 40.4 16.5 41.7 36.9 42.5 191.0 29.4 34.4 5.7 40.9 21.0 40.8 119.6 127.1 45.3 79.0 31.6 35.2 42.8 21.4 17.7 38.3 30.0 18.9 25.0 1.7 49.4 98.9 40.7 31.2 23.5 5.0 33.8 111.4 26.6 29.0 37.0 23.4 55.6 48.2 52.4 48.3 186.6 22.2 43.8 45.7 91.8 84.8 53.7 27.1 13.1 30.7 24.9 46.4 24.0 35.5 38.9 28.3 53.7 23.3 71.0 65.9 NT5C3B "cN-IIIB, MGC20781, NT5C3L" ENSG00000141698 "5'-nucleotidase, cytosolic IIIB" Q969T7 17 41825057-41836260 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Nucleotide metabolism" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 131.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "A549: 39.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030786, HPA057095" Approved NA NA "Cluster 30: Non-specific - Translation" "Cluster 35: Non-specific - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Basic cellular processes" "HPA030786: AB_10602716, HPA057095: AB_2683333" "unprognostic (3.90e-2)" "unprognostic (5.75e-2)" "unprognostic (8.87e-2)" "unprognostic (1.46e-1)" "unprognostic (2.25e-1)" "unprognostic (1.21e-1)" "prognostic unfavorable (8.11e-5)" "unprognostic (3.40e-2)" "unprognostic (6.05e-2)" "unprognostic (2.31e-1)" "prognostic favorable (2.67e-4)" "unprognostic (3.07e-1)" "unprognostic (7.17e-3)" "unprognostic (2.36e-2)" "unprognostic (4.80e-3)" "unprognostic (7.14e-3)" "unprognostic (1.42e-2)" 7.9 7.6 12.4 1.5 12.8 1.2 7.6 15.5 13.4 7.6 10.8 12.9 1.9 7.0 3.3 6.3 7.0 3.2 7.1 13.0 12.3 11.1 8.7 6.5 2.8 10.9 11.3 7.4 11.5 2.8 9.9 3.0 10.6 9.0 1.1 3.6 7.8 4.2 6.0 4.7 6.5 4.8 10.0 5.7 8.9 9.5 11.8 0.9 13.0 5.6 1.9 8.9 6.8 12.7 8.1 39.5 7.8 12.7 8.6 6.0 3.2 9.5 8.5 12.9 14.3 34.0 2.1 9.3 5.6 6.3 8.6 8.3 8.2 9.9 4.6 5.9 19.7 4.1 21.8 17.8 10.1 0.1 4.7 5.3 5.4 17.4 6.5 4.7 7.5 13.8 3.6 2.4 8.6 18.0 8.2 5.1 5.0 7.9 4.2 6.2 13.2 7.8 3.7 10.0 6.0 3.5 13.4 13.8 4.9 6.7 6.7 6.3 7.1 5.3 5.4 9.3 9.5 2.7 5.6 4.2 4.2 0.1 8.1 1.1 2.3 0.3 1.8 0.5 2.5 1.8 2.4 1.8 2.4 2.5 1.9 2.1 1.3 0.7 0.4 1.3 0.4 2.0 12.4 12.8 15.5 13.4 13.0 12.3 10.9 11.3 10.6 10.0 11.8 12.7 24.8 9.6 17.2 15.0 16.9 18.1 58.7 47.3 33.6 33.8 45.1 61.1 13.6 22.8 16.6 29.5 18.8 39.0 8.7 5.1 101.8 51.6 99.8 10.9 26.8 29.1 39.4 2.5 14.2 41.6 56.2 35.2 14.3 12.1 11.4 40.1 26.7 24.0 13.4 116.1 15.5 13.2 32.6 13.2 18.5 121.6 32.3 11.7 35.6 6.5 5.8 42.4 6.2 13.0 7.2 39.1 9.8 30.5 15.5 78.7 1.4 65.1 12.7 36.5 39.5 31.1 49.3 131.8 30.0 19.8 17.2 31.2 13.8 23.7 15.2 44.6 NT5E "CALJA, CD73, eN, eNT, NT5" ENSG00000135318 "5'-nucleotidase ecto" P21589 6 85449584-85495791 "CD markers, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" Hydrolase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "cervix: 112.6;retina: 94.4" "Cell type enhanced" "Detected in many" "Glandular and luminal cells: 58.0;Oligodendrocyte precursor cells: 61.3;Pancreatic endocrine cells: 124.8;Rod photoreceptor cells: 81.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "naive B-cell: 33.0;naive CD8 T-cell: 30.7" "Group enriched" "Detected in many" 41 "B-cells: 33.0;T-cells: 30.7" "Cell line enhanced" "Detected in many" "hTERT-RPE1: 807.8;LHCN-M2: 934.3;TIME: 546.2;U-87 MG: 821.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017357 Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" "Intracellular and membrane" NA NA 3000000 "Cluster 21: B-cells - Adaptive immune response" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane" "Nucleoplasm, Cytosol" "HPA017357: AB_1846330" "unprognostic (1.92e-2)" "unprognostic (4.44e-3)" "unprognostic (1.54e-1)" "unprognostic (1.57e-3)" "unprognostic (9.33e-2)" "unprognostic (1.82e-3)" "unprognostic (1.20e-2)" "prognostic unfavorable (6.66e-4)" "unprognostic (5.45e-2)" "unprognostic (1.80e-1)" "prognostic unfavorable (1.32e-5)" "unprognostic (1.39e-1)" "unprognostic (3.11e-2)" "prognostic unfavorable (1.02e-4)" "unprognostic (3.49e-2)" "unprognostic (2.26e-1)" "unprognostic (2.78e-1)" 20.7 6.0 9.8 11.9 11.9 0.6 14.1 11.2 10.7 112.6 14.9 29.4 40.1 49.4 6.3 8.6 20.7 17.2 8.7 8.5 11.3 17.2 54.8 6.8 9.6 11.7 14.1 39.3 1.8 1.8 11.8 25.3 13.0 13.3 31.9 94.4 6.6 34.2 2.1 6.4 20.9 73.9 14.7 13.0 8.1 10.4 12.7 5.2 23.7 9.8 11.3 15.8 28.5 12.1 48.9 26.0 42.9 0.8 95.1 302.4 0.4 306.1 332.7 147.5 275.2 0.4 469.6 0.0 107.3 270.2 379.0 24.5 0.1 308.0 348.8 0.8 0.1 0.1 7.3 6.0 47.5 0.2 0.7 77.4 3.7 302.0 191.3 807.8 124.9 0.3 0.3 1.4 934.3 8.3 0.0 0.2 0.8 8.2 34.6 1.5 9.5 1.3 323.1 21.8 0.3 5.5 3.8 18.8 104.9 2.2 0.4 8.3 546.2 120.6 0.9 152.9 506.8 22.7 15.3 0.5 821.7 0.4 385.3 0.0 0.0 0.5 3.7 0.0 6.4 23.7 4.2 11.7 0.0 33.0 4.1 30.7 0.5 0.7 0.0 0.1 1.7 6.4 9.8 11.9 11.2 10.7 8.5 11.3 11.7 14.1 13.0 14.7 12.7 12.1 6.4 0.0 5.8 36.9 21.6 5.2 1.7 6.1 2.8 4.4 1.2 0.3 1.7 27.1 4.8 1.8 10.4 0.6 2.2 49.2 3.9 3.8 0.6 19.3 20.8 20.5 0.0 0.0 1.6 4.1 2.5 39.4 11.2 58.0 0.0 0.1 49.6 33.7 1.3 0.0 2.1 27.7 0.0 3.5 8.2 1.3 13.1 2.1 7.2 11.2 0.5 9.1 0.0 61.3 0.7 124.8 46.0 25.6 3.6 1.5 8.3 27.6 4.8 81.6 0.0 3.3 9.6 0.0 0.3 0.6 4.8 15.2 5.0 0.1 18.0 9.6 NT5M "dNT-2, dNT2, mdN" ENSG00000205309 "5',3'-nucleotidase, mitochondrial" Q9NPB1 17 17303335-17347663 "Metabolic proteins, Predicted intracellular proteins" "Nucleotide metabolism" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 13.3" "Cell type enhanced" "Detected in many" "Distal tubular cells: 17.6;Erythroid cells: 31.2;Horizontal cells: 16.8;Inhibitory neurons: 13.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "eosinophil: 1.3" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "JURKAT: 8.5;RPMI-8226: 6.3;U-266/70: 9.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043777 Uncertain NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 47: Non-specific - Unknown function" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 6: Erythroid cells - Oxygen transport" "HPA043777: AB_10962842" "unprognostic (5.70e-2)" "unprognostic (3.20e-2)" "unprognostic (1.06e-2)" "unprognostic (2.59e-2)" "unprognostic (8.61e-3)" "unprognostic (1.24e-1)" "unprognostic (1.60e-1)" "unprognostic (1.61e-1)" "unprognostic (2.48e-1)" "prognostic favorable (8.42e-5)" "unprognostic (4.28e-5)" "unprognostic (2.27e-1)" "unprognostic (4.93e-2)" "unprognostic (3.89e-2)" "unprognostic (1.05e-1)" "unprognostic (7.93e-2)" "unprognostic (1.05e-2)" 1.1 0.6 6.3 0.2 5.9 4.7 0.9 6.4 7.9 2.2 4.6 2.8 0.4 2.1 0.4 0.9 1.6 0.4 7.1 5.6 5.8 2.2 1.0 0.8 0.3 6.2 6.1 1.9 1.1 1.8 4.5 0.2 6.4 1.8 0.1 0.5 0.8 0.7 13.3 0.8 0.8 0.4 5.7 0.9 1.1 6.8 7.3 1.1 0.8 4.6 0.2 2.0 1.1 6.4 0.3 0.7 0.3 2.9 1.7 1.9 1.2 0.6 0.2 0.2 0.4 0.0 0.2 3.3 1.8 0.0 0.5 0.0 0.1 0.1 0.0 2.9 1.8 2.3 0.1 0.3 1.7 0.6 4.3 1.4 1.5 0.3 1.1 0.6 0.0 8.5 2.0 0.0 0.0 0.8 2.8 2.6 1.8 1.0 2.5 2.1 0.2 6.3 1.0 0.0 3.6 5.9 1.0 0.1 2.6 2.1 1.0 0.9 0.0 0.9 1.0 0.2 0.8 9.3 1.3 0.5 0.5 0.4 2.4 0.0 0.0 1.3 0.0 0.0 0.4 0.0 0.0 0.5 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 6.3 5.9 6.4 7.9 5.6 5.8 6.2 6.1 6.4 5.7 7.3 6.4 1.1 0.0 0.5 11.1 0.5 1.7 2.1 0.1 2.2 5.5 3.4 6.1 7.9 1.5 0.6 9.2 2.1 1.0 2.6 0.4 17.6 0.3 0.9 0.3 3.3 1.7 1.2 31.2 7.6 0.6 1.2 2.5 1.1 0.9 0.0 5.2 0.7 1.3 1.5 16.8 13.2 0.8 0.0 0.8 0.6 4.4 0.6 3.4 0.0 3.7 0.3 4.7 2.1 4.0 5.4 0.0 0.1 1.2 2.3 3.2 0.1 2.9 0.0 1.8 0.0 7.4 1.8 1.5 6.0 1.8 0.4 0.5 2.3 3.2 0.5 1.3 NUDT5 "hYSAH1, YSA1H" ENSG00000165609 "Nudix hydrolase 5" Q9UKK9 10 12165330-12196144 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019827 Approved Approved Nucleoplasm,Vesicles,Centrosome NA NA 1500000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 64: Macrophages - Immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Vesicles "Nucleoplasm, Centrosome" "HPA019827: AB_1854704" "unprognostic (2.08e-2)" "unprognostic (2.10e-1)" "unprognostic (1.61e-1)" "unprognostic (2.09e-1)" "unprognostic (3.77e-3)" "unprognostic (4.91e-2)" "unprognostic (2.54e-2)" "unprognostic (4.60e-2)" "unprognostic (1.32e-1)" "unprognostic (6.39e-3)" "unprognostic (2.06e-1)" "unprognostic (9.97e-2)" "prognostic unfavorable (7.14e-12)" "unprognostic (1.61e-1)" "unprognostic (1.33e-1)" "unprognostic (3.12e-2)" "unprognostic (3.68e-2)" 35.1 32.4 23.0 30.6 26.4 24.1 26.7 27.5 30.5 24.6 29.5 32.0 27.5 14.3 23.7 40.7 24.6 18.4 14.9 23.4 26.0 36.3 88.8 26.0 39.3 27.3 24.9 18.0 25.9 33.1 35.5 31.1 27.4 21.0 36.0 27.4 25.1 14.0 6.2 33.2 25.4 17.6 25.0 34.2 22.6 13.1 25.4 53.5 27.8 7.6 47.4 28.9 27.8 31.8 136.4 98.0 114.6 107.1 107.5 105.6 100.8 96.9 61.5 111.9 119.1 142.5 125.9 134.2 82.4 79.2 70.0 133.1 162.0 150.6 102.1 110.8 160.8 111.9 114.3 209.3 112.0 77.1 75.2 111.7 88.4 122.3 61.7 86.3 144.9 209.4 153.5 88.9 103.2 123.8 143.5 87.0 100.4 215.0 60.1 128.0 42.4 157.2 106.0 46.1 56.6 82.3 117.4 90.8 142.2 132.0 155.9 77.9 91.6 47.0 90.6 134.3 121.9 74.3 141.6 179.3 99.7 97.3 36.0 29.6 60.8 115.2 69.9 65.7 80.4 72.7 73.9 82.6 87.6 64.6 50.4 68.4 163.8 57.4 52.2 149.2 123.4 71.6 23.0 26.4 27.5 30.5 23.4 26.0 27.3 24.9 27.4 25.0 25.4 31.8 42.1 25.6 55.1 23.2 43.8 43.0 57.8 121.2 28.5 21.1 28.6 30.7 4.5 32.9 72.3 23.9 16.7 82.6 49.8 35.0 74.3 82.2 35.3 61.1 44.4 42.6 38.3 43.5 34.6 82.9 150.6 40.3 33.1 31.9 31.7 41.4 41.7 131.8 128.7 21.9 38.2 41.2 79.3 41.8 32.2 11.7 39.4 39.7 30.2 12.2 85.0 37.4 62.8 34.2 41.2 73.8 35.2 29.0 66.1 33.7 52.6 130.6 103.9 25.5 32.9 21.2 40.1 20.2 33.6 52.4 60.5 58.1 49.7 54.4 57.4 46.9 NUDT9 MGC3037 ENSG00000170502 "Nudix hydrolase 9" Q9BW91 4 87422573-87459455 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RPTEC TERT1: 160.7" "Low region specificity" "Detected in all" "HPA036917, HPA044866, HPA078535" Approved Approved "Nuclear membrane,Nuclear bodies,Cell Junctions,Mitochondria" "Intracellular and membrane" NA NA 9900 "Cluster 27: Non-specific - Gene expression" "Cluster 29: Non-specific - Vesicular transport" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Nuclear bodies, Mitochondria" "Nuclear membrane, Cell Junctions" "HPA036917: AB_10696790, HPA044866: AB_2679120, HPA078535: AB_2686885" "unprognostic (7.22e-2)" "unprognostic (2.59e-2)" "unprognostic (1.45e-2)" "prognostic favorable (7.43e-5)" "unprognostic (2.05e-2)" "unprognostic (1.36e-1)" "unprognostic (1.33e-1)" "unprognostic (3.47e-2)" "unprognostic (2.04e-1)" "unprognostic (1.02e-1)" "unprognostic (1.09e-2)" "unprognostic (4.23e-1)" "prognostic favorable (8.00e-11)" "unprognostic (1.21e-1)" "unprognostic (1.99e-1)" "unprognostic (1.19e-1)" "unprognostic (5.77e-3)" 23.6 36.1 20.8 16.2 21.4 6.7 19.7 25.5 38.5 27.6 39.1 27.0 42.6 24.8 32.2 19.6 24.9 16.2 28.8 21.9 24.7 40.4 46.6 23.0 13.7 21.0 20.5 26.7 67.6 55.3 29.1 19.9 21.9 30.4 27.1 20.1 28.1 23.8 42.1 16.6 40.3 23.8 19.6 14.7 22.3 22.5 22.1 13.4 28.8 45.0 14.8 22.4 24.3 26.0 30.8 25.6 34.0 19.8 67.6 39.6 26.0 59.8 35.6 21.3 21.1 17.1 53.1 47.6 58.9 47.6 41.0 21.1 32.1 38.1 33.2 34.5 24.0 13.4 34.5 31.8 42.4 25.6 21.2 41.5 52.4 25.6 22.6 45.5 41.6 13.7 40.3 30.0 38.7 33.4 39.1 23.2 29.1 68.5 12.0 45.0 31.8 27.0 160.7 24.2 41.3 28.7 37.6 63.0 30.8 44.5 36.8 38.2 43.7 34.7 34.3 25.8 27.8 21.5 18.7 37.9 51.3 21.9 48.2 1.6 17.9 5.9 19.1 21.2 18.2 22.2 18.5 19.5 21.4 18.8 22.5 26.0 1.8 15.6 24.0 20.6 19.0 16.0 20.8 21.4 25.5 38.5 21.9 24.7 21.0 20.5 21.9 19.6 22.1 26.0 32.6 67.3 44.8 20.2 14.9 9.9 40.4 45.0 9.6 15.3 11.3 13.1 40.9 30.0 55.0 23.9 27.1 33.2 13.1 21.0 41.1 44.7 28.6 26.0 26.2 25.8 16.8 6.7 21.7 36.5 32.5 29.4 8.6 27.0 20.8 23.3 18.2 47.5 33.2 6.7 24.0 18.0 40.7 12.7 11.0 11.5 25.4 14.7 10.6 20.6 16.4 26.8 8.2 18.6 24.8 29.4 37.0 26.7 15.8 32.9 55.7 56.2 41.0 18.6 26.3 36.9 23.7 44.5 23.6 15.7 9.5 37.6 12.1 29.8 24.9 27.3 PAPOLA PAP ENSG00000090060 "Poly(A) polymerase alpha" P51003 14 96501433-96567111 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "mRNA processing" "RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 1036.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001788 Supported Supported Nucleoplasm NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 28: BEWO - Transcription regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA001788: AB_1079564" "unprognostic (3.18e-1)" "unprognostic (1.30e-1)" "unprognostic (9.69e-2)" "unprognostic (7.26e-2)" "unprognostic (9.10e-2)" "unprognostic (5.10e-3)" "prognostic unfavorable (2.41e-5)" "unprognostic (2.12e-2)" "unprognostic (2.82e-2)" "unprognostic (1.38e-3)" "unprognostic (3.13e-1)" "unprognostic (1.22e-3)" "unprognostic (3.37e-1)" "unprognostic (1.65e-1)" "unprognostic (1.77e-1)" "unprognostic (1.08e-2)" "unprognostic (4.05e-1)" 52.6 60.5 62.7 66.6 65.1 96.9 62.7 71.7 87.4 61.7 70.1 70.5 57.1 68.5 72.5 59.6 57.9 56.1 61.0 59.9 64.4 60.7 81.6 50.0 77.8 63.0 61.7 76.1 71.6 73.2 53.0 85.3 64.3 54.2 71.8 92.4 63.8 54.0 46.7 57.9 67.6 61.6 62.8 69.3 65.9 75.8 62.1 93.0 68.9 56.4 82.8 66.4 53.5 80.7 126.6 119.4 150.5 152.6 107.2 119.4 331.6 112.9 120.4 132.1 125.8 132.9 125.6 170.9 125.3 134.1 115.2 104.4 50.1 156.9 235.0 141.1 81.1 131.9 88.9 138.5 110.6 166.2 133.4 110.6 134.1 148.0 131.1 127.8 150.5 79.5 128.2 146.5 128.9 184.6 140.5 91.1 102.9 205.0 135.3 146.7 183.5 98.7 132.0 192.7 154.0 102.0 151.4 115.8 111.6 167.9 165.3 158.3 119.0 91.3 72.6 104.1 140.7 114.3 186.7 138.6 144.5 137.5 158.9 73.5 32.0 56.1 23.8 39.3 29.0 38.9 30.2 34.2 38.8 42.7 35.3 33.9 41.3 41.3 37.7 25.1 32.7 36.6 62.7 65.1 71.7 87.4 59.9 64.4 63.0 61.7 64.3 62.8 62.1 80.7 126.3 80.1 122.4 64.6 171.4 229.7 406.3 196.6 126.9 78.2 140.0 101.6 157.2 88.6 160.1 84.6 95.9 346.2 139.6 124.1 183.9 121.4 634.7 326.1 145.4 150.7 117.2 126.8 87.9 137.0 440.7 129.9 95.3 371.7 136.4 113.8 85.6 112.3 155.6 63.9 111.5 154.9 168.9 141.3 239.4 275.3 96.3 153.2 168.9 104.9 171.8 93.4 135.9 105.1 115.2 129.6 118.9 80.5 197.4 373.0 122.5 136.5 253.1 107.2 105.2 131.6 185.0 256.8 203.0 146.0 247.6 1036.0 167.8 131.2 166.1 540.3 PAPOLB PAPT ENSG00000218823 "Poly(A) polymerase beta" Q9NRJ5 7 4857738-4862030 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "mRNA processing" "RNA-binding, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 22 "testis: 29.9" "Cell type enhanced" "Detected in some" "Early spermatids: 94.8;Late spermatids: 89.7;Smooth muscle cells: 18.5;Spermatocytes: 37.4" "Not detected" "Not detected" "Region enriched" "Detected in single" 5 "cerebellum: 1.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA047285 Approved Nucleoplasm NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA047285: " "unprognostic (7.58e-2)" "unprognostic (1.25e-1)" "unprognostic (1.68e-2)" "unprognostic (1.78e-1)" 0.0 0.0 0.2 0.0 0.2 0.0 0.0 1.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 29.9 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 1.3 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.0 0.0 0.0 0.0 0.4 1.2 0.2 0.0 0.9 0.2 0.1 1.3 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 94.8 0.2 1.0 0.2 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 89.7 2.5 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.6 0.0 0.0 0.2 0.8 0.0 0.7 18.5 37.4 4.0 0.0 0.9 0.3 0.1 0.1 0.0 0.3 PAPOLG FLJ12972 ENSG00000115421 "Poly(A) polymerase gamma" Q9BWT3 2 60756253-60802086 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "mRNA processing" "RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017795, HPA035349, HPA035350" Approved Enhanced Nucleoplasm No No "Cluster 38: Basophils - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 24: Non-specific - Transcription regulation" Nucleoplasm "CAB017795: , HPA035349: AB_2674583, HPA035350: AB_2674584" "unprognostic (1.83e-1)" "unprognostic (1.06e-1)" "unprognostic (2.14e-1)" "unprognostic (3.39e-2)" "unprognostic (5.56e-2)" "unprognostic (3.54e-1)" "unprognostic (6.72e-4)" "unprognostic (2.49e-1)" "unprognostic (6.97e-3)" "unprognostic (6.83e-2)" "unprognostic (1.95e-1)" "unprognostic (1.88e-1)" "prognostic unfavorable (4.21e-4)" "unprognostic (2.67e-1)" "unprognostic (1.99e-2)" "unprognostic (3.06e-2)" "unprognostic (2.62e-2)" 3.7 3.0 2.2 2.2 2.3 1.4 3.4 3.2 3.1 4.2 1.7 3.2 1.3 4.1 1.2 3.5 3.2 1.4 3.1 2.3 2.3 2.5 2.3 3.2 3.0 2.5 2.1 4.9 3.5 1.7 3.1 2.0 2.5 2.6 1.5 4.0 3.8 1.2 4.2 3.7 3.6 1.5 1.9 4.1 3.4 3.5 2.6 3.7 6.2 1.7 2.5 3.2 4.1 3.0 1.8 1.5 3.4 2.0 3.1 3.7 2.4 1.5 1.9 1.4 1.2 2.4 1.3 2.6 1.7 1.3 1.4 2.8 3.7 1.8 2.3 4.0 2.1 4.0 1.7 1.7 1.9 4.4 2.4 2.2 2.5 1.7 3.7 2.9 2.6 2.6 3.2 1.9 1.4 1.4 5.0 3.6 5.3 2.9 1.1 3.4 4.9 2.7 1.9 1.4 1.6 2.4 2.2 2.7 1.9 3.2 1.3 2.7 2.4 1.8 1.8 1.3 1.7 2.4 1.5 5.4 2.2 4.8 1.4 3.7 0.8 1.5 1.3 1.0 1.7 1.1 1.2 1.2 0.7 1.4 1.7 1.5 2.2 1.4 1.2 0.8 2.2 0.8 2.2 2.3 3.2 3.1 2.3 2.3 2.5 2.1 2.5 1.9 2.6 3.0 11.5 12.8 12.2 13.1 13.9 12.5 13.5 4.6 12.0 6.8 8.4 8.6 7.9 7.2 8.8 9.2 25.0 6.0 21.0 6.9 3.9 4.8 4.7 6.1 13.2 10.9 2.4 13.3 29.5 4.3 4.6 11.0 6.6 6.6 13.3 14.6 11.7 5.0 7.4 5.0 24.8 5.7 10.2 10.4 22.7 4.3 7.5 17.8 12.4 25.3 12.0 5.1 8.2 19.1 22.1 4.9 6.0 8.6 12.7 15.4 4.3 3.5 7.1 10.3 26.3 9.3 11.3 30.3 17.3 13.2 15.9 8.8 20.8 10.6 4.0 16.2 PAPSS1 "ATPSK1, PAPSS" ENSG00000138801 "3'-phosphoadenosine 5'-phosphosulfate synthase 1" O43252 4 107590276-107720234 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Multifunctional enzyme, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Glandular and luminal cells: 444.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 6 "basophil: 321.8;eosinophil: 359.8" "Lineage enriched" "Detected in all" 6 "granulocytes: 359.8" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049781 Approved Approved "Nucleoplasm,Nucleoli rim,Mitotic chromosome" Yes No 13000 "Cluster 2: Granulocytes - Unknown function" "Cluster 27: Brain & Skin - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 44: Endometrium - Transcription" "Nucleoli rim, Mitotic chromosome" Nucleoplasm "HPA049781: AB_2680879" "unprognostic (1.36e-2)" "unprognostic (5.03e-2)" "prognostic favorable (9.14e-4)" "prognostic favorable (8.58e-4)" "unprognostic (1.63e-2)" "unprognostic (1.08e-1)" "prognostic unfavorable (2.70e-5)" "unprognostic (1.58e-2)" "unprognostic (1.05e-1)" "unprognostic (8.92e-2)" "unprognostic (1.42e-1)" "unprognostic (5.76e-2)" "unprognostic (6.23e-3)" "unprognostic (1.29e-1)" "unprognostic (1.72e-1)" "unprognostic (1.61e-2)" "unprognostic (1.38e-1)" 26.3 14.2 36.8 30.8 43.9 26.0 49.9 46.4 50.0 49.6 26.5 20.4 16.0 47.1 43.0 36.2 48.4 26.4 15.9 41.9 40.8 31.7 10.3 44.4 32.9 53.2 41.4 29.2 49.3 26.9 15.8 17.2 51.8 41.1 24.7 22.3 66.0 25.9 6.1 49.7 15.8 33.6 51.1 17.4 62.8 17.0 41.8 35.4 20.3 9.9 51.7 31.7 23.7 66.3 33.6 29.7 49.1 62.1 59.1 74.0 39.6 42.4 77.2 39.4 53.1 45.7 46.7 51.3 26.0 76.1 30.4 40.7 46.8 81.6 50.5 124.2 35.5 60.4 62.6 103.0 32.3 93.0 99.8 61.7 41.2 45.7 37.1 95.2 88.7 63.9 13.6 97.0 111.6 50.7 77.3 28.2 52.6 35.3 33.1 62.4 78.0 15.0 59.6 45.6 55.5 81.4 42.9 63.3 51.9 61.9 37.9 14.1 52.9 49.3 51.0 33.6 35.4 76.9 57.2 48.7 60.1 69.3 79.2 321.8 49.9 359.8 15.6 56.2 18.8 44.8 21.2 18.0 51.4 26.4 13.2 14.9 55.5 27.6 60.8 9.8 39.9 36.7 36.8 43.9 46.4 50.0 41.9 40.8 53.2 41.4 51.8 51.1 41.8 66.3 19.7 96.1 20.2 41.4 25.4 32.0 36.3 73.2 33.6 19.9 48.4 41.5 7.4 50.1 92.3 57.0 10.4 20.6 7.0 10.5 17.6 36.8 6.2 124.2 84.6 25.1 23.4 15.3 112.2 44.7 48.7 35.2 62.2 444.3 42.5 25.0 20.3 10.2 55.1 30.3 64.7 17.5 32.6 46.5 27.8 6.7 18.0 53.5 60.5 29.0 37.4 35.0 10.3 100.0 150.3 33.6 9.1 25.6 86.4 29.1 6.9 28.8 110.0 13.3 26.3 45.2 29.1 19.6 14.7 62.9 40.9 8.9 22.2 19.2 14.8 29.4 PAPSS2 ATPSK2 ENSG00000198682 "3'-phosphoadenosine 5'-phosphosulfate synthase 2" O95340 10 87659613-87747705 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Multifunctional enzyme, Nucleotidyltransferase, Transferase" "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 135.2" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 240.4;Distal enterocytes: 202.4;Hepatocytes: 111.5;Proximal enterocytes: 181.3;Theca cells: 96.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "intermediate monocyte: 4.0;myeloid DC: 2.1;non-classical monocyte: 7.7" "Group enriched" "Detected in many" 7 "dendritic cells: 2.1;monocytes: 7.7" "Cell line enhanced" "Detected in many" "BJ: 189.8;fHDF/TERT166: 473.2;HHSteC: 196.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA071224, HPA075267" Enhanced Approved Mitochondria No No 16000 "Cluster 7: Monocytes - Unknown function" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 41: Macrophages - Immune response" Mitochondria "HPA071224: AB_2686366, HPA075267: " "unprognostic (3.98e-3)" "unprognostic (7.06e-2)" "unprognostic (4.95e-3)" "unprognostic (1.02e-1)" "unprognostic (2.67e-1)" "unprognostic (1.61e-2)" "unprognostic (4.96e-2)" "unprognostic (1.15e-1)" "prognostic unfavorable (1.33e-6)" "unprognostic (3.50e-2)" "prognostic favorable (6.58e-4)" "unprognostic (1.14e-1)" "unprognostic (4.90e-2)" "unprognostic (6.72e-3)" "unprognostic (1.73e-1)" "prognostic unfavorable (3.21e-5)" "unprognostic (3.46e-3)" 33.3 135.2 6.3 26.6 7.0 2.0 20.9 6.2 9.5 17.8 6.2 79.9 29.5 8.5 3.1 10.2 12.4 20.7 11.6 5.8 6.2 23.8 77.0 70.4 11.0 6.9 6.6 27.5 26.1 2.1 3.0 58.5 7.5 6.7 64.3 2.3 16.4 3.4 4.7 3.5 61.8 16.7 6.8 8.5 9.2 11.7 8.0 3.0 21.3 8.7 14.8 16.6 11.5 7.2 19.9 20.0 6.4 0.3 129.4 164.8 0.3 189.8 157.7 110.4 79.9 1.0 4.1 0.1 9.8 473.2 3.5 8.5 13.9 13.3 125.2 0.2 10.0 8.8 13.4 0.1 196.5 0.2 3.8 58.7 0.3 63.7 5.2 135.6 94.2 1.4 0.0 89.4 79.2 74.1 0.1 0.7 7.4 4.8 24.1 0.4 0.1 0.4 117.5 8.7 0.9 1.6 92.5 3.3 1.1 12.6 13.5 5.3 120.0 38.2 22.5 131.5 13.9 0.3 1.0 0.3 18.3 0.2 0.2 0.0 1.1 0.0 0.0 4.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.6 0.0 7.7 0.0 0.0 0.8 6.3 7.0 6.2 9.5 5.8 6.2 6.9 6.6 7.5 6.8 8.0 7.2 49.5 240.4 38.2 3.6 2.6 2.3 0.9 18.0 1.8 0.2 11.5 4.7 4.4 8.6 13.8 9.2 0.0 0.5 0.8 202.4 13.7 6.4 1.2 2.6 18.7 23.2 12.6 5.2 22.2 30.2 0.8 36.1 15.3 11.6 0.0 20.3 36.0 111.5 11.5 0.0 27.6 26.5 4.1 29.8 50.7 0.8 17.4 51.0 1.8 30.0 5.2 1.3 0.0 21.6 1.0 19.4 46.1 5.3 3.1 2.1 181.3 9.8 3.4 0.0 13.1 1.0 20.4 1.2 0.7 1.1 1.3 1.4 1.7 96.4 74.3 1.1 PDE10A ENSG00000112541 "Phosphodiesterase 10A" Q9Y233 6 165327287-165988078 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Allosteric enzyme, Hydrolase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 11 "brain: 67.2" "Cell type enhanced" "Detected in many" "Excitatory neurons: 204.7;Inhibitory neurons: 209.6;Microglial cells: 89.0;Oligodendrocyte precursor cells: 48.7;Oligodendrocytes: 51.8" "Low cancer specificity" "Detected in many" "Region enriched" "Detected in many" 6 "basal ganglia: 67.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HeLa: 9.0;LHCN-M2: 12.5;RT4: 6.9;SH-SY5Y: 8.1;TIME: 11.3;U-2 OS: 7.0" "Region enriched" "Detected in all" 11 "basal ganglia: 350.1" "Region enriched" "Detected in all" 5 "basal ganglia: 194.1" "CAB045998, HPA047200" Supported NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB045998: AB_2162589, HPA047200: AB_2679981" "unprognostic (1.02e-1)" "unprognostic (3.63e-2)" "unprognostic (3.58e-2)" "unprognostic (2.91e-1)" "unprognostic (1.20e-1)" "unprognostic (1.25e-1)" "unprognostic (1.76e-1)" "unprognostic (1.23e-1)" "unprognostic (9.36e-2)" "unprognostic (6.03e-2)" "unprognostic (3.79e-2)" "unprognostic (9.24e-2)" "prognostic unfavorable (4.44e-7)" "unprognostic (3.59e-3)" "unprognostic (2.37e-2)" "unprognostic (3.44e-2)" "unprognostic (5.90e-3)" 2.6 1.3 3.1 0.8 67.2 0.0 2.3 5.5 10.7 1.3 0.0 1.0 0.2 2.0 2.4 0.4 2.4 1.5 3.6 2.1 2.5 3.8 0.3 1.0 0.5 1.6 2.3 2.3 0.5 0.5 2.7 2.5 0.9 1.7 0.2 1.9 0.4 1.7 0.4 0.3 0.7 2.1 0.5 1.4 1.1 3.4 9.6 0.3 6.0 0.5 0.4 3.2 0.9 0.1 0.0 2.4 5.5 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 6.3 0.8 0.0 0.0 0.0 3.8 0.1 2.2 0.0 0.0 0.1 3.9 0.0 9.0 0.0 0.4 0.0 0.0 0.0 0.0 0.6 0.0 0.0 5.5 0.0 0.0 0.0 12.5 0.3 0.9 0.0 1.1 0.0 4.7 1.5 5.8 0.0 5.9 6.9 1.8 8.1 0.0 0.0 0.4 0.7 0.0 0.0 11.3 0.1 7.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 3.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.1 67.2 5.5 10.7 2.1 2.5 1.6 2.3 0.9 0.5 9.6 0.1 13.8 0.0 0.0 10.4 0.1 0.4 3.3 0.4 0.0 7.2 0.3 0.3 7.3 0.0 1.2 5.5 2.1 7.8 0.0 0.0 3.9 2.0 14.3 0.2 1.7 13.4 0.0 0.0 204.7 0.0 6.1 6.6 1.1 0.4 1.3 0.1 7.9 0.0 0.8 16.8 209.6 0.0 0.0 0.0 0.0 14.9 0.0 0.2 1.8 89.0 0.0 12.6 0.0 48.7 51.8 0.1 0.0 0.4 0.0 17.9 0.0 7.2 0.9 1.1 0.0 12.4 5.0 8.8 2.1 0.1 0.3 2.9 0.1 1.6 0.1 6.9 PDE11A ENSG00000128655 "Phosphodiesterase 11A" Q9HCR9 2 177623244-178072777 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Allosteric enzyme, Hydrolase" "Cushing syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 6.3;parathyroid gland: 9.8" "Cell type enhanced" "Detected in many" "Early spermatids: 37.0;Hepatocytes: 11.1;Late spermatids: 46.4;Oligodendrocytes: 14.9" "Cancer enhanced" "Detected in some" "prostate cancer: 1.7" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CAPAN-2: 1.6;fHDF/TERT166: 2.4;HAP1: 1.4;Hep G2: 2.8" HPA034560 Approved "Intracellular and membrane" NA NA "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 25: Spermatids - Spermatogenesis" "HPA034560: AB_10602140" "unprognostic (1.02e-1)" "unprognostic (4.73e-2)" "unprognostic (1.02e-1)" "unprognostic (9.61e-3)" "unprognostic (2.34e-2)" "unprognostic (1.43e-2)" "unprognostic (1.30e-1)" "unprognostic (2.28e-2)" "unprognostic (2.23e-1)" "unprognostic (3.91e-1)" "unprognostic (9.95e-2)" "unprognostic (2.80e-2)" "unprognostic (5.06e-2)" "unprognostic (1.04e-1)" "unprognostic (1.75e-1)" "unprognostic (4.11e-4)" "unprognostic (1.64e-3)" 2.3 0.3 0.8 0.1 2.0 0.2 1.7 1.9 1.2 0.6 0.6 0.5 0.8 1.2 0.4 0.0 0.3 0.4 0.3 0.6 2.1 0.5 6.3 0.0 0.0 2.5 2.1 0.4 1.1 9.8 0.9 0.0 2.7 5.2 0.4 1.4 1.4 0.8 4.4 0.1 0.5 1.1 3.7 0.1 0.4 2.8 1.9 0.1 1.3 1.3 0.0 0.0 0.1 3.2 0.0 0.4 0.2 0.1 0.0 0.0 0.0 1.1 0.2 0.0 0.3 0.2 1.6 0.0 0.6 2.4 0.3 0.1 1.4 0.0 0.0 0.0 0.9 1.1 0.1 2.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.9 0.0 0.2 0.2 0.4 0.1 0.6 0.0 0.3 0.2 0.0 0.2 0.0 0.5 0.0 0.3 0.7 0.0 0.1 0.1 0.2 0.1 0.0 0.0 0.1 0.3 0.0 0.1 0.2 0.0 0.0 0.4 0.0 0.1 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.1 0.1 0.1 0.0 0.0 0.8 2.0 1.9 1.2 0.6 2.1 2.5 2.1 2.7 3.7 1.9 3.2 0.1 0.0 0.0 2.3 0.2 0.6 1.4 0.1 0.0 1.7 4.2 0.8 0.0 1.5 0.1 0.0 0.0 0.1 0.3 0.8 0.0 0.8 37.0 0.3 0.2 0.6 6.7 2.7 1.6 6.7 0.0 0.6 0.0 0.2 0.0 0.0 1.4 11.1 0.1 0.0 8.2 0.9 6.1 1.2 2.1 46.4 1.5 0.3 0.0 0.0 0.0 4.7 0.0 6.0 14.9 2.3 0.0 0.7 0.0 5.4 0.6 1.3 0.1 1.0 0.0 2.0 0.6 6.8 6.9 0.0 1.3 0.3 0.3 0.3 1.3 1.0 PDE1A ENSG00000115252 "Phosphodiesterase 1A" P54750 2 182140036-182523192 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Calmodulin-binding, Hydrolase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 46.6;thyroid gland: 45.8" "Cell type enhanced" "Detected in many" "Early spermatids: 396.3;Excitatory neurons: 764.9;Late spermatids: 592.1;Oligodendrocytes: 1178.0" "Cancer enhanced" "Detected in many" "thyroid cancer: 13.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "ASC diff: 37.2;HHSteC: 22.0;HSkMC: 47.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA022151 Approved Approved Nucleoplasm NA NA "Cluster 43: Testis - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "HPA022151: AB_1855118" "unprognostic (3.63e-1)" "unprognostic (7.21e-2)" "unprognostic (1.32e-1)" "unprognostic (8.61e-2)" "unprognostic (1.58e-1)" "unprognostic (3.02e-1)" "unprognostic (3.84e-1)" "unprognostic (3.82e-1)" "unprognostic (1.02e-1)" "unprognostic (5.38e-2)" "unprognostic (2.78e-1)" "unprognostic (2.86e-1)" "unprognostic (5.55e-3)" "unprognostic (2.50e-3)" "unprognostic (5.96e-2)" "unprognostic (1.37e-1)" "unprognostic (1.40e-3)" 10.5 4.4 16.9 4.6 20.4 0.0 5.0 35.5 23.4 17.2 2.4 11.8 3.0 8.7 8.0 5.6 10.3 23.7 15.6 30.3 8.4 46.6 3.9 3.6 2.1 2.6 4.2 10.9 2.1 2.2 2.7 1.2 5.4 3.6 6.7 1.4 2.0 5.4 2.8 2.2 5.7 12.9 3.7 3.1 5.6 35.6 16.5 8.4 45.8 5.0 0.9 9.7 9.8 18.2 0.0 0.2 3.9 0.0 37.2 3.1 0.1 0.3 0.4 0.1 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.1 4.7 0.0 5.1 0.0 22.0 0.0 0.0 47.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 7.5 1.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 3.7 0.0 5.4 0.1 0.1 0.2 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 16.9 20.4 35.5 23.4 30.3 8.4 2.6 4.2 5.4 3.7 16.5 18.2 6.7 0.0 2.6 15.3 0.0 1.3 2.0 0.1 8.0 20.0 0.3 0.3 5.9 1.5 1.4 27.6 0.0 0.1 0.0 0.1 185.9 0.5 396.3 0.3 0.4 8.9 0.0 0.0 764.9 0.4 0.0 18.6 0.0 0.8 0.0 0.1 5.0 0.0 0.1 0.0 185.8 1.0 0.0 0.0 1.8 592.1 14.9 0.4 0.0 30.0 0.0 0.3 0.0 18.1 1178.0 0.2 0.1 8.2 0.2 2.6 0.1 1.5 0.0 1.2 52.6 21.0 45.1 9.1 4.9 1.0 1.3 0.0 0.2 7.6 0.1 0.7 PDE1B PDES1B ENSG00000123360 "Phosphodiesterase 1B" Q01064 12 54549601-54579239 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Calmodulin-binding, Hydrolase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "brain: 76.9" "Cell type enhanced" "Detected in many" "Excitatory neurons: 18.6;Inhibitory neurons: 10.2;Kupffer cells: 13.0;Macrophages: 9.4;Sertoli cells: 13.1;Smooth muscle cells: 13.7" "Low cancer specificity" "Detected in many" "Region enriched" "Detected in many" 6 "basal ganglia: 76.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HDLM-2: 12.7;HMC-1: 14.9;NB-4: 10.7;THP-1: 9.0;U-937: 7.2" "Region enriched" "Detected in all" 6 "basal ganglia: 999.4" "Region enriched" "Detected in all" 7 "basal ganglia: 228.7" HPA018492 Enhanced NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 3: HMC-1 - Innate immune response" "Cluster 48: Smooth muscle cells - ECM organization" "HPA018492: AB_1855119" "unprognostic (2.90e-1)" "unprognostic (1.51e-1)" "unprognostic (7.67e-4)" "unprognostic (5.63e-3)" "unprognostic (7.02e-2)" "unprognostic (7.51e-2)" "unprognostic (1.97e-1)" "unprognostic (9.39e-2)" "unprognostic (1.14e-1)" "unprognostic (5.11e-2)" "unprognostic (3.84e-3)" "unprognostic (2.70e-2)" "prognostic unfavorable (4.77e-6)" "unprognostic (6.64e-4)" "unprognostic (2.14e-1)" "unprognostic (3.09e-1)" "unprognostic (2.83e-2)" 9.1 1.1 8.4 4.0 76.9 4.8 4.6 0.0 13.7 2.0 0.0 7.4 1.0 2.7 1.8 1.7 2.0 2.2 1.4 6.3 0.1 0.8 1.0 2.3 1.3 0.0 0.0 8.6 0.4 6.1 0.3 0.2 0.0 1.3 1.0 0.4 1.0 1.4 0.6 1.4 3.4 4.0 0.0 4.0 3.3 0.7 2.4 0.9 2.0 1.0 0.8 8.7 1.5 4.9 0.0 0.0 0.6 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 3.2 0.1 0.0 0.0 0.0 2.1 0.0 0.0 12.7 0.6 4.3 0.0 0.0 0.0 5.5 14.9 0.7 0.0 0.0 0.0 0.0 0.0 5.5 0.0 2.3 0.0 0.0 0.5 10.7 3.5 0.0 0.0 2.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 9.0 0.0 0.0 0.3 0.0 0.0 0.1 0.2 2.5 0.0 7.2 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.4 76.9 0.0 13.7 6.3 0.1 0.0 0.0 0.0 0.0 2.4 4.9 2.3 0.0 1.1 1.6 1.8 1.0 0.2 0.0 0.6 2.7 0.2 0.6 3.6 0.0 0.6 3.7 0.0 0.1 1.4 0.0 0.0 0.0 6.3 0.1 0.0 0.8 1.8 3.6 18.6 0.0 0.0 1.5 0.0 0.0 0.0 4.4 0.0 0.3 8.5 5.0 10.2 0.0 0.0 13.0 2.5 4.9 2.1 9.4 0.0 2.8 6.7 0.1 4.1 1.0 0.9 0.0 0.0 3.0 2.6 0.4 0.0 0.0 0.0 0.2 13.1 0.6 13.7 0.8 0.6 0.2 0.4 0.3 2.8 0.4 0.1 0.1 PDE1C Hcam3 ENSG00000154678 "Phosphodiesterase 1C" Q14123 7 31751179-32428131 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Calmodulin-binding, Hydrolase" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "brain: 68.9;heart muscle: 58.5" "Cell type enriched" "Detected in many" 5 "Oligodendrocytes: 1071.4" "Cancer enhanced" "Detected in some" "glioma: 1.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ: 44.4;fHDF/TERT166: 148.3;hTERT-RPE1: 44.9;U-251 MG: 77.9;WM-115: 105.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA052375 Approved Nucleoplasm NA NA "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA052375: AB_2681802" "unprognostic (1.29e-2)" "unprognostic (2.20e-5)" "unprognostic (1.68e-2)" "unprognostic (1.20e-3)" "unprognostic (2.29e-1)" "unprognostic (5.65e-2)" "unprognostic (4.06e-3)" "unprognostic (2.75e-1)" "unprognostic (6.79e-3)" "unprognostic (6.49e-2)" "unprognostic (3.88e-5)" "unprognostic (7.03e-2)" "unprognostic (3.09e-3)" "unprognostic (5.76e-2)" "unprognostic (5.80e-2)" "unprognostic (1.49e-1)" "unprognostic (1.06e-3)" 2.4 1.8 19.2 2.5 43.0 0.0 4.3 21.4 39.9 0.7 0.0 3.0 1.4 2.4 6.0 6.4 10.5 1.5 58.5 18.9 24.2 4.2 0.1 4.9 0.6 29.4 27.9 3.8 2.6 0.3 1.3 3.2 27.7 2.0 1.8 7.4 1.8 3.2 0.6 0.4 3.3 5.0 16.4 0.6 4.0 3.8 28.6 1.6 3.1 4.0 0.1 9.8 1.4 68.9 0.3 5.8 15.5 0.0 0.6 0.4 0.2 44.4 18.3 20.8 17.1 0.0 0.0 0.0 0.2 148.3 0.0 1.2 0.0 0.0 27.1 0.0 0.0 1.3 1.4 0.0 0.1 0.0 31.9 1.9 0.0 4.3 0.2 44.9 7.1 0.0 0.1 0.1 1.7 0.0 0.1 0.0 0.0 0.0 13.7 0.0 0.0 0.0 22.5 0.0 6.8 0.0 0.0 0.0 0.0 1.3 0.0 0.3 0.2 22.8 8.6 0.4 77.9 0.4 0.0 0.0 2.4 0.5 105.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.2 43.0 21.4 39.9 18.9 24.2 29.4 27.9 27.7 16.4 28.6 68.9 1.2 0.0 0.0 7.5 0.1 0.0 0.7 0.1 1.2 69.5 2.8 17.1 136.0 0.0 0.7 1.8 52.1 0.0 0.1 0.0 0.0 4.8 53.4 0.2 0.1 3.9 0.0 0.0 70.8 0.4 0.0 8.7 0.0 0.4 8.8 0.2 0.0 0.0 0.1 3.3 169.2 0.0 59.0 0.0 0.2 50.3 0.3 0.5 0.0 15.9 0.0 0.9 0.0 196.6 1071.4 0.2 0.0 0.4 0.1 0.2 0.0 0.0 2.2 4.7 0.0 0.9 9.4 1.3 1.2 0.2 0.0 0.0 0.1 1.2 0.0 0.0 PDE2A ENSG00000186642 "Phosphodiesterase 2A" O00408 11 72576141-72674591 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 197.0" "Group enriched" "Detected in many" 6 "Adipocytes: 114.9;Endothelial cells: 58.5;Enteroendocrine cells: 34.4;Excitatory neurons: 70.1;Hepatic stellate cells: 118.2;Inhibitory neurons: 35.6" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in many" 4 "amygdala: 75.1;basal ganglia: 84.7;cerebral cortex: 102.1;hippocampal formation: 84.4;white matter: 48.3" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in many" 5 "B-cells: 2.8;T-cells: 7.3" "Cell line enriched" "Detected in some" 8 "HeLa: 513.6" "Low region specificity" "Detected in some" "Group enriched" "Detected in all" 5 "amygdala: 83.5;basal ganglia: 146.9;cerebral cortex: 90.5;hippocampal formation: 94.0" "CAB009752, HPA031192" Enhanced Supported Cytosol NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 64: Macrophages - Immune response" "Cluster 20: HeLa - Mitochondria" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Cytosol "CAB009752: AB_2268159, HPA031192: AB_2673781" "unprognostic (1.92e-1)" "unprognostic (1.52e-3)" "unprognostic (4.58e-2)" "unprognostic (1.49e-1)" "unprognostic (1.26e-1)" "unprognostic (2.50e-1)" "prognostic favorable (1.76e-6)" "unprognostic (3.06e-2)" "unprognostic (1.35e-1)" "unprognostic (3.01e-3)" "unprognostic (3.13e-3)" "unprognostic (1.50e-2)" "unprognostic (1.77e-2)" "unprognostic (2.85e-3)" "unprognostic (6.31e-2)" "unprognostic (7.72e-2)" "unprognostic (7.96e-4)" 89.2 44.1 75.1 5.1 84.7 4.7 83.6 0.0 102.1 38.1 0.0 34.6 6.0 27.2 8.3 18.6 39.3 22.7 41.1 84.4 7.0 32.5 19.4 12.6 6.7 6.4 5.1 11.6 6.9 5.5 11.8 12.0 10.1 20.7 8.9 3.0 9.2 10.7 16.8 18.1 18.7 18.5 0.0 197.0 17.1 7.4 17.9 3.8 24.1 28.9 3.5 28.8 27.1 48.3 0.3 0.2 0.7 0.2 0.2 0.1 0.3 0.1 0.2 0.2 0.4 0.4 2.5 0.8 12.2 0.2 1.9 0.2 0.9 0.1 0.1 0.1 0.1 0.0 513.6 0.8 0.9 0.0 7.8 0.1 1.1 2.7 20.5 1.1 11.3 0.5 0.8 0.9 0.1 0.0 0.2 0.2 7.4 0.2 14.0 0.0 0.2 1.4 0.1 0.3 44.5 2.4 0.4 0.2 2.2 0.7 0.3 0.1 65.2 0.1 9.4 3.5 0.4 0.4 0.2 0.1 3.9 0.1 0.6 0.0 0.6 0.0 7.3 0.8 4.2 2.8 4.3 4.3 1.0 1.8 2.7 2.3 0.1 0.0 0.4 0.0 1.8 1.5 75.1 84.7 0.0 102.1 84.4 7.0 6.4 5.1 10.1 0.0 17.9 48.3 114.9 0.0 0.5 2.0 0.7 2.5 0.1 0.0 0.0 4.9 0.6 1.0 7.8 0.0 0.0 0.0 0.0 0.0 1.6 0.2 0.0 0.0 0.6 0.0 0.1 58.5 34.4 5.3 70.1 0.0 0.3 2.1 0.0 0.1 1.3 0.1 118.2 2.1 0.5 1.7 35.6 1.2 0.0 9.4 8.2 2.5 0.3 4.9 1.8 11.2 0.0 0.0 0.0 9.0 5.7 0.1 0.0 0.4 1.5 0.1 0.0 0.1 0.0 0.4 0.0 1.8 6.6 4.8 2.5 0.5 2.8 0.0 0.6 0.2 0.1 0.3 PDE3A CGI-PDE ENSG00000172572 "Phosphodiesterase 3A" Q14432 12 20368537-20688583 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" Hydrolase "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 43.4" "Cell type enhanced" "Detected in many" "Astrocytes: 98.2;Bipolar cells: 38.4;Cardiomyocytes: 131.3;Horizontal cells: 52.2;Inhibitory neurons: 78.8;Smooth muscle cells: 49.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 8.6;HEL: 15.3;HeLa: 42.5;HUVEC TERT2: 7.4;SH-SY5Y: 17.9;U-138 MG: 11.9" "Low region specificity" "Detected in many" "Region enhanced" "Detected in many" "cerebellum: 18.8" "HPA014492, HPA074258" Approved Approved "Plasma membrane" NA NA 37000000 "Cluster 46: Fibroblasts - ECM organization" "Cluster 20: HeLa - Mitochondria" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane" "HPA014492: AB_1855120, HPA074258: " "unprognostic (2.59e-2)" "unprognostic (2.94e-2)" "unprognostic (1.25e-1)" "unprognostic (3.23e-1)" "unprognostic (2.27e-1)" "unprognostic (1.21e-1)" "unprognostic (3.50e-2)" "unprognostic (1.67e-2)" "unprognostic (8.14e-2)" "unprognostic (1.49e-1)" "unprognostic (4.25e-1)" "unprognostic (3.37e-1)" "prognostic unfavorable (1.72e-6)" "unprognostic (5.58e-2)" "unprognostic (5.94e-2)" "unprognostic (4.28e-2)" "unprognostic (2.76e-4)" 6.5 1.0 1.6 3.1 1.3 0.2 3.8 3.1 1.3 6.7 1.8 15.0 1.9 4.2 1.4 2.2 4.1 4.7 43.4 1.3 1.5 3.3 1.3 3.9 1.0 1.9 2.3 3.4 6.2 0.6 2.1 11.3 1.2 5.4 7.6 5.7 2.7 3.5 2.2 1.3 9.6 5.2 1.6 2.2 5.1 0.4 2.5 0.6 2.8 1.8 0.5 2.5 3.1 1.4 0.0 0.2 8.6 0.0 1.9 1.3 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 15.3 42.5 0.2 0.6 0.0 0.0 1.8 0.0 0.4 0.1 0.1 7.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.4 0.0 1.1 0.0 0.0 0.0 2.7 0.0 0.1 17.9 0.0 0.0 0.1 3.3 0.0 0.0 0.3 11.9 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 1.3 3.1 1.3 1.3 1.5 1.9 2.3 1.2 1.6 2.5 1.4 2.7 0.0 0.0 98.2 0.0 0.3 0.2 0.0 0.6 38.4 0.2 0.3 131.3 4.3 0.6 0.0 0.0 0.0 0.0 28.4 0.0 5.8 0.7 0.5 1.6 3.9 4.2 0.0 4.1 0.5 0.0 11.3 0.0 1.4 17.1 0.0 2.2 0.0 0.7 52.2 78.8 7.0 0.0 0.0 0.7 0.6 1.5 3.1 1.8 27.2 0.5 4.4 0.0 27.6 3.9 0.4 26.9 0.7 0.0 0.5 33.4 3.1 0.0 2.8 6.6 3.6 49.9 0.3 0.9 0.9 0.3 0.0 0.6 0.5 16.4 0.2 PDE3B HcGIP1 ENSG00000152270 "Phosphodiesterase 3B" Q13370 11 14643804-14872044 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted membrane proteins" Angiogenesis Hydrolase "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 64.5" "Cell type enhanced" "Detected in many" "Astrocytes: 171.7;Excitatory neurons: 140.5;Inhibitory neurons: 158.0;Microglial cells: 192.0;Oligodendrocyte precursor cells: 118.6" "Low cancer specificity" "Detected in many" "Region enriched" "Detected in all" 5 "cerebellum: 13.5" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in many" 5 "granulocytes: 3.8;T-cells: 6.3" "Cell line enhanced" "Detected in many" "HL-60: 23.5;Karpas-707: 25.7;THP-1: 28.4;U-266/70: 28.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056111 Approved "Endoplasmic reticulum" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 29: U-266 - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" "Endoplasmic reticulum" "HPA056111: AB_2683041" "unprognostic (1.05e-1)" "unprognostic (2.86e-2)" "unprognostic (4.12e-2)" "unprognostic (2.76e-3)" "unprognostic (4.25e-1)" "unprognostic (1.84e-3)" "unprognostic (3.40e-2)" "unprognostic (3.24e-2)" "unprognostic (5.39e-2)" "unprognostic (1.20e-1)" "prognostic favorable (7.91e-4)" "unprognostic (1.77e-1)" "unprognostic (2.33e-2)" "unprognostic (1.39e-2)" "unprognostic (3.42e-1)" "unprognostic (2.47e-1)" "unprognostic (9.03e-3)" 64.5 1.1 1.3 12.4 2.1 10.1 12.2 13.5 2.6 3.4 0.0 25.2 2.9 0.7 0.5 2.9 0.5 3.7 4.7 1.9 2.6 3.0 25.8 10.2 14.9 2.8 1.7 0.5 8.3 0.2 4.4 7.6 1.9 8.7 10.7 0.5 14.0 1.6 0.4 0.5 6.0 1.7 2.3 8.9 2.6 9.6 2.0 7.3 0.8 2.4 7.9 8.5 1.9 2.6 0.0 2.5 5.6 9.2 10.9 0.1 2.2 0.6 0.1 0.0 0.0 8.5 0.0 0.0 0.1 0.0 2.6 0.0 8.5 0.0 0.0 0.2 18.7 0.3 13.1 17.5 3.9 23.5 0.1 0.8 0.0 0.0 0.5 0.0 0.1 6.6 20.6 25.7 0.0 0.3 4.7 11.4 7.6 3.1 4.1 11.0 2.5 17.7 0.0 1.9 8.5 15.8 2.3 14.6 5.1 2.5 0.0 28.4 0.0 0.0 1.3 0.0 0.0 28.8 9.4 0.7 0.2 4.0 1.7 0.0 0.5 2.5 1.0 0.6 2.1 0.2 3.1 2.4 0.3 0.1 6.3 5.7 3.8 0.1 1.0 0.1 3.5 1.5 1.3 2.1 13.5 2.6 1.9 2.6 2.8 1.7 1.9 2.3 2.0 2.6 1.5 16.0 8.9 171.7 6.4 0.3 0.9 0.0 0.6 1.0 0.3 0.3 11.1 0.0 6.2 1.8 0.0 1.4 26.7 11.5 1.9 0.0 19.0 0.3 5.1 4.0 1.2 12.8 140.5 5.0 2.8 9.7 7.7 0.3 36.1 0.5 4.2 64.1 7.6 0.0 158.0 13.7 0.0 13.1 3.7 13.4 1.5 15.6 0.0 192.0 10.8 6.3 8.2 118.6 5.4 1.8 22.3 9.1 28.9 3.3 0.7 2.0 3.6 0.5 0.0 3.4 3.0 48.8 19.5 0.1 0.1 2.5 60.9 0.0 9.4 1.1 PDE4A DPDE2 ENSG00000065989 "Phosphodiesterase 4A" P27815 19 10416773-10469630 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" Hydrolase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Langerhans cells: 190.8;Late spermatids: 197.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HMC-1: 36.5;NB-4: 43.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017632, HPA043310, HPA076091" Uncertain Supported "Nucleoplasm,Plasma membrane" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 47: Non-specific - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 25: Spermatids - Spermatogenesis" "Plasma membrane" Nucleoplasm "CAB017632: AB_1127109, HPA043310: AB_2678419, HPA076091: AB_2686775" "unprognostic (1.29e-2)" "unprognostic (3.98e-2)" "unprognostic (8.91e-2)" "unprognostic (1.82e-1)" "unprognostic (7.00e-2)" "unprognostic (6.84e-2)" "unprognostic (1.54e-2)" "unprognostic (4.39e-2)" "unprognostic (7.91e-2)" "unprognostic (1.52e-2)" "unprognostic (6.90e-2)" "unprognostic (2.41e-1)" "unprognostic (2.27e-2)" "unprognostic (1.64e-2)" "unprognostic (2.57e-2)" "unprognostic (1.67e-1)" "unprognostic (2.15e-1)" 13.7 5.6 10.9 5.9 12.5 5.4 9.7 3.0 32.3 12.4 0.0 11.0 2.7 9.8 1.4 4.1 7.5 6.6 12.5 11.8 7.9 7.0 2.5 13.0 3.2 21.9 7.1 1.5 12.7 22.2 3.9 6.5 20.8 8.4 4.0 5.3 9.8 4.8 37.9 5.4 6.5 6.2 1.1 8.2 12.9 24.5 13.0 1.6 11.0 16.9 2.6 8.2 8.2 15.7 0.1 2.5 0.5 6.7 18.7 11.1 3.7 5.6 11.1 0.7 1.9 6.0 5.4 2.6 16.1 14.6 0.4 0.6 3.9 0.7 0.4 6.7 5.5 23.7 8.1 6.7 12.3 3.9 36.5 8.3 0.8 6.2 0.0 0.7 5.3 2.1 18.9 5.5 4.0 1.7 2.3 43.3 2.9 6.7 4.7 15.6 3.7 20.3 0.9 1.4 4.2 1.5 0.4 0.2 6.2 1.0 0.8 7.8 11.2 8.3 10.5 5.7 3.7 10.9 0.9 12.4 3.5 0.3 6.7 4.1 1.7 3.4 0.8 2.5 0.4 0.1 0.3 1.1 2.0 0.0 0.0 0.4 0.1 3.0 2.7 0.1 0.7 1.1 10.9 12.5 3.0 32.3 11.8 7.9 21.9 7.1 20.8 1.1 13.0 15.7 9.4 3.2 11.6 6.2 10.8 10.1 2.6 2.5 1.8 25.6 6.4 4.3 7.7 8.6 5.5 9.2 0.0 0.5 58.9 7.1 0.0 3.1 48.9 2.1 20.7 8.6 0.0 1.7 39.4 12.9 4.8 12.1 7.1 3.6 31.8 0.3 10.4 0.9 10.2 55.5 43.5 5.1 6.1 22.1 190.8 197.0 17.4 53.9 14.2 12.2 15.4 1.2 22.6 12.5 1.5 12.3 3.8 18.0 27.0 3.0 0.1 0.2 6.9 3.6 6.6 9.0 10.2 8.6 8.5 0.5 8.1 0.4 37.0 1.0 6.8 1.3 PDE4B DPDE4 ENSG00000184588 "Phosphodiesterase 4B" Q07343 1 65792514-66374579 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Hydrolase "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 75.5;brain: 109.1" "Group enriched" "Detected in many" 5 "Oligodendrocyte precursor cells: 1722.6;Oligodendrocytes: 4039.6" "Cancer enhanced" "Detected in all" "glioma: 18.9" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 88.9" "Group enriched" "Detected in all" 5 "B-cells: 37.4;granulocytes: 88.9;T-cells: 34.7" "Cell line enhanced" "Detected in many" "AN3-CA: 61.8;HUVEC TERT2: 93.2;NTERA-2: 56.1;SK-MEL-30: 58.6;TIME: 52.6;U-266/84: 51.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003005 Uncertain Approved "Golgi apparatus,Cytosol" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 70: Brain - Nervous system development" "Cluster 12: NES - Nervous system development" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Golgi apparatus" Cytosol "HPA003005: AB_1079587" "unprognostic (7.86e-2)" "unprognostic (3.13e-1)" "unprognostic (4.62e-2)" "unprognostic (2.90e-1)" "unprognostic (3.21e-1)" "unprognostic (3.33e-3)" "unprognostic (1.35e-1)" "unprognostic (1.15e-3)" "unprognostic (1.04e-2)" "unprognostic (6.10e-2)" "unprognostic (8.78e-2)" "unprognostic (4.24e-2)" "prognostic unfavorable (5.04e-4)" "unprognostic (2.89e-2)" "unprognostic (3.54e-1)" "unprognostic (9.04e-3)" "unprognostic (8.33e-3)" 18.3 3.1 40.1 39.5 82.5 75.5 20.0 63.3 53.5 7.2 1.6 8.3 4.6 8.3 1.1 4.5 4.2 10.1 21.4 45.7 68.4 5.4 10.9 14.7 23.2 85.9 74.4 2.1 1.6 1.4 3.8 17.2 78.5 23.0 10.5 14.1 21.1 12.1 44.3 8.9 12.2 12.4 66.4 22.6 5.1 3.8 62.9 14.0 7.2 15.0 19.9 32.1 4.6 109.1 0.2 18.5 34.7 61.8 1.6 1.7 0.1 11.5 13.3 10.1 13.4 0.0 0.0 5.3 0.2 20.7 0.4 0.1 0.3 0.0 9.7 15.5 0.1 0.3 5.2 0.0 1.2 13.1 0.0 3.4 0.5 4.5 0.2 1.6 93.2 0.0 0.0 3.3 4.7 0.3 0.0 7.5 56.1 0.0 0.7 2.6 6.2 3.6 8.7 0.0 0.2 26.6 0.0 3.0 58.6 2.9 0.2 4.5 52.6 7.2 1.9 4.6 1.9 1.5 51.6 19.3 8.6 13.4 3.7 10.8 6.8 22.0 10.1 5.8 19.5 36.8 19.4 14.8 6.2 37.4 21.3 15.0 88.9 11.3 5.7 6.4 34.7 9.6 40.1 82.5 63.3 53.5 45.7 68.4 85.9 74.4 78.5 66.4 62.9 109.1 24.7 9.6 12.2 531.8 233.3 20.3 28.4 0.5 27.9 40.9 51.6 34.3 25.4 0.0 6.9 5.5 0.0 7.3 79.8 0.4 0.0 0.8 14.4 1.7 14.9 36.8 4.2 0.0 315.6 0.9 2.0 20.2 9.7 4.2 15.2 0.2 11.7 2.4 13.0 114.4 559.7 1.9 8.2 40.6 187.4 9.4 0.3 176.9 51.6 173.3 67.0 19.3 1.0 1722.6 4039.6 0.1 0.4 2.6 351.9 93.6 0.0 2.1 1.5 4.0 0.0 54.0 10.3 0.7 0.8 4.8 8.1 5.6 143.1 0.4 1.3 9.4 PDE4C DPDE1 ENSG00000105650 "Phosphodiesterase 4C" Q08493 19 18208652-18248200 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" Hydrolase "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "tongue: 21.3" "Cell type enhanced" "Detected in many" "Distal enterocytes: 255.9;Gastric mucus-secreting cells: 141.2;Paneth cells: 251.4;Proximal enterocytes: 73.0;Skeletal myocytes: 106.5;Undifferentiated cells: 103.3" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in some" 4 "basal ganglia: 1.2;cerebral cortex: 1.1" "Immune cell enhanced" "Detected in single" "basophil: 1.0" "Lineage enriched" "Detected in single" 4 "granulocytes: 1.0" "Cell line enhanced" "Detected in some" "BEWO: 2.9;Hep G2: 2.0;U-87 MG: 4.4" "HPA048975, HPA054218" Approved Approved "Midbody ring,Centrosome,Cytosol" Yes NA "Cluster 17: Basophils - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 53: Intestinal epithelial cells - Unknown function" "Centrosome, Cytosol" "Midbody ring" "HPA048975: AB_2680581, HPA054218: " "unprognostic (4.20e-2)" "unprognostic (4.02e-2)" "unprognostic (1.20e-1)" "unprognostic (1.27e-1)" "unprognostic (5.22e-4)" "unprognostic (1.44e-2)" "unprognostic (7.70e-2)" "unprognostic (1.15e-1)" "unprognostic (4.01e-2)" "unprognostic (5.69e-2)" "unprognostic (2.50e-3)" "unprognostic (2.21e-1)" "unprognostic (7.25e-10)" "unprognostic (2.73e-2)" "unprognostic (2.65e-1)" "unprognostic (9.21e-2)" "unprognostic (2.45e-2)" 1.4 0.6 0.2 0.1 1.2 0.5 0.7 0.0 1.1 3.2 0.0 4.3 0.7 3.4 3.4 0.7 3.0 1.1 4.4 0.2 0.0 4.8 1.3 3.4 0.2 0.0 0.0 1.8 0.7 0.2 2.8 3.7 0.0 2.3 0.6 0.2 0.5 2.7 8.3 0.3 2.4 1.8 0.0 2.1 3.8 2.5 0.0 0.0 1.1 21.3 0.1 1.0 1.7 0.0 0.0 0.1 0.0 0.1 0.0 0.1 2.9 0.0 0.0 0.1 0.1 0.6 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 2.0 0.1 0.0 0.2 0.3 0.0 1.2 0.0 0.2 0.0 0.1 0.4 0.9 0.0 0.1 0.1 0.1 0.0 0.2 0.1 0.1 0.1 0.2 0.0 0.0 0.1 0.4 0.1 0.2 0.0 0.7 0.2 0.2 0.0 0.1 0.0 0.3 0.0 0.6 0.3 0.1 4.4 0.1 0.0 1.0 0.1 0.2 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.2 0.1 0.1 0.7 0.2 0.1 0.1 0.0 0.0 0.2 1.2 0.0 1.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 3.2 10.6 2.0 0.8 5.5 5.8 8.6 5.2 3.9 0.2 0.4 35.3 4.3 22.4 0.0 6.2 2.1 0.0 255.9 0.0 0.0 32.9 0.1 0.1 4.6 7.2 0.0 8.2 0.0 4.3 6.3 141.2 0.1 4.5 0.0 1.1 0.3 0.5 0.0 2.1 55.2 4.1 1.4 4.5 38.4 0.6 2.1 1.8 0.0 0.4 1.9 1.0 0.5 0.9 0.0 251.4 4.1 1.6 1.8 73.0 0.0 9.4 3.0 46.0 106.5 17.2 1.9 2.2 28.6 3.8 1.1 1.2 0.0 103.3 17.3 PDE4D DPDE3 ENSG00000113448 "Phosphodiesterase 4D" Q08499 5 58969038-60522120 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 74.9;skeletal muscle: 70.4" "Cell type enhanced" "Detected in many" "Astrocytes: 619.3;Excitatory neurons: 2969.7;Inhibitory neurons: 1116.9;Oligodendrocyte precursor cells: 848.0;Oligodendrocytes: 443.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in many" 5 "eosinophil: 57.9" "Lineage enriched" "Detected in many" 5 "granulocytes: 57.9" "Cell line enhanced" "Detected in many" "A549: 62.2;AN3-CA: 70.4;HeLa: 104.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045895 Uncertain Supported "Plasma membrane,Cytosol" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 20: HeLa - Mitochondria" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" Cytosol "HPA045895: AB_10960275" "unprognostic (1.14e-1)" "unprognostic (8.73e-3)" "unprognostic (4.35e-2)" "unprognostic (7.87e-2)" "unprognostic (5.97e-2)" "unprognostic (2.03e-1)" "unprognostic (8.10e-4)" "unprognostic (1.17e-1)" "unprognostic (6.59e-2)" "unprognostic (1.84e-1)" "unprognostic (2.71e-1)" "unprognostic (2.65e-1)" "prognostic favorable (4.00e-5)" "unprognostic (1.51e-1)" "unprognostic (8.20e-2)" "unprognostic (1.77e-2)" "unprognostic (2.56e-2)" 8.9 1.3 3.3 9.8 9.9 74.9 4.6 0.0 11.3 5.3 0.0 21.0 5.5 7.4 18.4 13.7 7.3 9.1 15.7 4.4 4.2 17.2 2.8 13.3 5.3 7.0 2.0 3.0 3.7 5.5 6.7 16.6 1.2 19.9 15.0 21.4 7.4 21.2 70.4 4.5 7.0 15.3 0.8 4.0 10.3 3.4 3.8 8.6 7.4 34.4 5.6 22.0 8.2 5.7 0.1 62.2 12.8 70.4 2.3 4.4 10.1 1.6 1.8 3.4 4.9 24.5 2.0 4.8 0.2 0.5 10.3 10.6 0.0 2.8 5.9 2.9 7.0 9.2 104.6 5.3 9.1 4.4 0.7 9.3 2.3 9.6 1.7 1.1 7.3 0.3 0.0 1.6 5.9 4.5 3.6 10.3 2.4 1.8 3.2 1.2 16.0 10.5 15.9 23.5 2.3 8.0 16.4 27.1 14.2 11.4 1.9 9.3 8.5 0.9 0.2 12.0 3.3 3.5 0.1 0.5 10.3 17.3 2.7 4.2 2.0 57.9 1.5 0.1 1.5 11.0 1.4 0.7 1.4 11.3 0.9 0.7 3.1 0.4 0.2 0.0 0.8 1.1 3.3 9.9 0.0 11.3 4.4 4.2 7.0 2.0 1.2 0.8 3.8 5.7 22.5 32.1 110.0 619.3 32.3 10.6 30.1 6.6 35.3 20.2 5.1 2.7 35.7 8.6 30.2 42.3 73.0 11.3 118.6 28.1 11.7 0.6 21.4 19.0 8.6 16.9 33.4 2.1 2969.7 1.8 25.7 27.5 40.2 21.9 22.2 0.3 17.2 0.8 5.2 1.7 1116.9 18.2 6.1 4.8 11.1 36.6 1.5 29.5 10.6 407.5 6.0 12.0 29.9 848.0 443.3 8.2 11.9 4.9 44.4 43.3 8.9 27.5 19.4 52.8 0.0 64.0 6.3 1.1 7.7 40.6 8.8 3.1 94.3 1.1 11.7 26.5 PDE5A ENSG00000138735 "Phosphodiesterase 5A" O76074 4 119494397-119628804 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Allosteric enzyme, Hydrolase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 66.1;Inhibitory neurons: 58.3;Oligodendrocyte precursor cells: 56.8;Peritubular cells: 104.9;Smooth muscle cells: 80.9" "Group enriched" "Detected in all" 4 "prostate cancer: 7.0;thyroid cancer: 27.3" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ hTERT+: 47.5;HHSteC: 65.9;hTERT-RPE1: 24.6" "Region enhanced" "Detected in all" "cerebellum: 18.2" "Low region specificity" "Detected in all" "HPA004729, HPA012873" Approved Approved Cytosol NA NA 850000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 48: Smooth muscle cells - ECM organization" Cytosol "HPA004729: AB_1079588, HPA012873: AB_1855124" "unprognostic (6.95e-2)" "prognostic favorable (5.20e-4)" "unprognostic (1.28e-1)" "unprognostic (1.56e-1)" "unprognostic (1.25e-1)" "unprognostic (3.66e-2)" "unprognostic (7.36e-2)" "unprognostic (2.58e-2)" "unprognostic (2.29e-2)" "unprognostic (6.97e-2)" "unprognostic (2.05e-2)" "unprognostic (2.54e-1)" "unprognostic (2.16e-2)" "unprognostic (1.52e-2)" "unprognostic (8.98e-2)" "unprognostic (8.71e-3)" "prognostic unfavorable (1.17e-4)" 15.4 11.3 0.9 10.9 3.5 2.1 9.6 4.9 3.7 32.7 12.6 37.0 15.5 14.4 41.5 41.3 22.9 10.4 12.8 1.4 3.6 5.9 1.5 22.1 6.4 4.9 8.2 5.4 12.4 8.3 3.5 13.2 5.2 59.8 25.9 9.6 9.8 49.8 6.9 5.0 18.9 11.4 0.0 5.8 9.6 9.4 3.4 3.7 16.8 5.6 3.5 14.6 15.8 1.9 16.7 0.8 11.0 1.2 3.7 5.5 1.9 10.7 47.5 0.5 1.0 1.0 1.3 1.6 0.5 13.4 3.0 5.8 3.5 1.7 1.3 0.4 7.4 18.5 2.6 0.9 65.9 3.9 1.7 6.1 3.3 1.1 0.1 24.6 1.4 3.7 2.0 2.9 1.6 0.9 5.0 0.6 2.3 1.8 2.8 0.7 5.9 4.3 4.1 4.9 4.3 8.8 13.0 15.3 1.3 8.1 2.7 2.1 2.5 6.2 5.2 3.4 1.5 4.1 2.0 1.5 5.9 1.0 0.9 0.0 0.0 0.0 0.1 0.0 0.5 0.4 0.3 0.1 0.0 0.3 0.1 0.2 0.4 0.2 0.1 0.1 0.1 1.2 0.9 3.5 4.9 3.7 1.4 3.6 4.9 8.2 5.2 0.0 3.4 1.9 7.8 6.4 3.9 19.9 1.3 3.4 2.8 1.1 5.7 8.1 11.0 8.4 5.5 14.3 3.7 1.8 14.6 0.4 0.9 15.5 0.0 15.8 30.6 5.0 12.6 7.8 2.4 0.0 66.1 2.9 0.3 28.1 1.1 3.9 1.3 1.6 0.7 0.9 0.3 5.0 58.3 9.5 2.0 0.0 3.5 11.5 20.8 11.3 5.4 40.3 1.3 28.5 2.1 56.8 41.1 3.9 10.3 104.9 1.4 3.6 7.9 0.5 0.8 5.8 19.7 5.5 80.9 5.4 6.3 3.5 2.4 0.3 1.7 7.0 11.1 2.6 PDE6A "PDEA, RP43" ENSG00000132915 "Phosphodiesterase 6A" P16499 5 149857953-149944793 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Sensory transduction, Vision" Hydrolase "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 68 "retina: 1119.5" "Cell type enriched" "Detected in many" 11 "Rod photoreceptor cells: 2946.4" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Immune cell enhanced" "Detected in single" "basophil: 1.1" "Low lineage specificity" "Detected in single" "Cell line enriched" "Detected in single" 5 "CACO-2: 2.5" "Not detected" "Not detected" "Not detected" "Not detected" "HPA016970, HPA074677" Enhanced NA NA "Cluster 11: Basophils - Unknown function" "Cluster 79: Retina - Phototransduction" "Cluster 39: CACO-2 - Unknown function" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA016970: AB_1855125, HPA074677: AB_2732264" "unprognostic (6.85e-2)" "unprognostic (8.84e-2)" "unprognostic (1.70e-2)" "unprognostic (4.11e-2)" "unprognostic (1.12e-2)" "unprognostic (5.72e-2)" "unprognostic (4.39e-3)" "unprognostic (8.83e-2)" "unprognostic (6.54e-2)" "unprognostic (5.91e-3)" "unprognostic (1.77e-2)" "unprognostic (9.21e-2)" "unprognostic (7.57e-5)" "unprognostic (9.93e-2)" "unprognostic (3.08e-1)" "unprognostic (1.31e-1)" "unprognostic (2.26e-2)" 0.1 0.7 0.5 0.2 0.5 0.9 0.2 1.4 0.7 0.1 0.2 1.2 0.2 0.1 16.3 0.9 0.2 0.2 0.2 0.5 0.5 0.1 0.1 0.3 0.1 0.3 0.3 0.2 0.2 0.2 1.7 0.1 0.5 0.3 0.9 1119.5 0.4 0.2 0.3 0.6 0.1 0.1 0.2 0.2 0.2 1.5 0.6 0.0 0.4 0.0 0.2 0.0 0.1 1.2 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.1 0.0 2.5 0.2 0.3 0.4 0.0 0.4 0.2 0.0 0.1 0.1 0.1 0.0 0.2 0.4 0.2 0.0 0.2 0.1 0.0 0.3 0.3 0.2 0.2 0.0 0.0 0.1 0.4 0.4 0.1 0.1 0.2 0.1 0.0 0.1 0.0 0.1 0.1 0.1 0.3 0.2 0.3 0.0 0.2 0.0 0.1 0.3 0.1 0.4 0.2 0.4 0.1 0.1 0.2 0.1 0.1 0.2 0.2 0.1 1.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.3 0.1 0.1 0.6 0.2 0.1 0.2 0.1 0.0 0.5 0.5 1.4 0.7 0.5 0.5 0.3 0.3 0.5 0.2 0.6 1.2 0.9 0.0 5.8 0.0 0.4 1.1 0.6 0.8 0.0 150.5 0.5 0.4 6.7 0.0 2.8 0.0 244.0 1.1 1.6 14.3 0.0 0.1 18.4 1.5 0.5 11.6 0.0 0.0 1.2 0.2 2.2 1.2 0.0 2.5 3.8 1.9 2.2 0.6 0.3 75.7 0.6 0.4 2.0 1.9 0.4 5.5 1.2 1.5 0.0 0.0 1.4 263.1 5.2 0.5 0.2 0.1 2.8 0.4 0.3 0.4 0.4 0.1 3.2 2946.4 0.0 1.0 1.2 2.3 0.8 5.4 0.6 2.9 1.5 2.2 2.7 0.2 PDE6B "CSNB3, CSNBAD2, PDEB, rd1, RP40" ENSG00000133256 "Phosphodiesterase 6B" P35913 4 625573-670782 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Sensory transduction, Vision" Hydrolase "Congenital stationary night blindness, Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in many" 10 "retina: 385.0" "Cell type enriched" "Detected in many" 5 "Rod photoreceptor cells: 460.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "EFO-21: 11.5;JURKAT: 17.3;MOLT-4: 31.3;REH: 16.8;SCLC-21H: 20.2;SH-SY5Y: 11.9;U-266/84: 24.0" "Not detected" "Not detected" "Not detected" "Not detected" "HPA054148, HPA059929" Enhanced Approved Cytosol NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 77: Retina - Visual perception" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 46: Photoreceptor cells - Phototransduction" Cytosol "HPA054148: AB_2682401, HPA059929: AB_2684166" "unprognostic (2.43e-2)" "unprognostic (1.33e-4)" "unprognostic (2.45e-4)" "unprognostic (7.18e-3)" "unprognostic (1.88e-2)" "unprognostic (5.04e-3)" "unprognostic (7.32e-3)" "prognostic favorable (5.34e-4)" "unprognostic (9.70e-2)" "unprognostic (1.14e-1)" "unprognostic (1.37e-2)" "unprognostic (2.33e-2)" "unprognostic (4.09e-2)" "unprognostic (1.67e-2)" "unprognostic (2.26e-1)" "unprognostic (2.41e-3)" "unprognostic (1.85e-1)" 1.9 2.2 13.5 5.5 25.7 8.4 4.1 8.2 22.3 2.5 1.9 1.7 1.2 2.7 4.0 1.7 10.2 3.7 5.9 11.2 22.6 4.9 1.0 4.6 14.3 22.8 19.9 2.8 1.8 8.2 4.1 3.1 25.5 2.8 1.3 385.0 3.8 3.0 1.1 2.1 3.0 2.5 9.3 10.1 2.9 4.4 24.1 12.2 12.0 0.1 9.3 3.8 1.4 39.3 0.1 0.0 1.2 0.5 0.3 0.4 0.4 0.0 0.1 0.8 2.0 0.0 0.1 0.3 11.5 0.3 0.9 0.1 2.5 0.6 0.0 0.1 0.0 1.0 0.3 0.1 5.8 0.2 0.4 0.7 0.0 3.5 0.0 0.8 1.1 17.3 0.1 1.0 0.1 0.3 31.3 0.1 9.4 0.7 0.0 16.8 0.2 0.2 2.1 1.3 20.2 11.9 0.0 0.3 0.1 4.2 0.6 0.0 0.4 0.2 1.2 0.2 0.4 7.7 24.0 0.3 0.3 0.3 0.2 16.8 5.4 0.9 14.0 7.7 12.6 12.8 9.3 9.8 8.5 21.4 14.6 15.8 1.4 14.4 8.1 18.2 15.5 9.4 13.5 25.7 8.2 22.3 11.2 22.6 22.8 19.9 25.5 9.3 24.1 39.3 0.5 3.2 5.0 4.2 6.4 0.4 2.1 1.2 2.8 20.7 3.9 2.4 4.4 0.0 3.5 0.0 83.4 0.1 8.4 0.2 1.9 6.9 0.4 7.0 2.2 2.9 1.8 7.4 40.3 0.6 0.3 1.3 1.5 2.5 3.8 5.4 2.2 0.0 11.3 11.8 27.3 0.5 4.1 5.1 1.4 0.3 1.5 3.3 3.6 4.7 6.2 31.1 7.2 10.1 33.9 0.8 0.2 1.5 7.5 1.9 0.0 8.4 11.2 460.1 0.0 1.6 1.1 4.3 11.0 1.9 0.3 0.3 5.9 3.5 0.4 1.3 PDE6C "ACHM5, COD4, PDEA2" ENSG00000095464 "Phosphodiesterase 6C" P51160 10 93612537-93666010 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Sensory transduction, Vision" Hydrolase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 26 "retina: 23.1" "Cell type enriched" "Detected in some" 13 "Cone photoreceptor cells: 56.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 9: Photoreceptor cells - Phototransduction" "unprognostic (1.39e-3)" "unprognostic (7.41e-3)" "unprognostic (2.61e-2)" "unprognostic (2.24e-1)" "unprognostic (3.17e-2)" "unprognostic (5.23e-3)" "unprognostic (2.46e-3)" "unprognostic (2.81e-3)" "unprognostic (9.68e-2)" "unprognostic (2.64e-1)" "unprognostic (1.51e-2)" "unprognostic (2.96e-3)" "unprognostic (2.19e-7)" "unprognostic (1.19e-1)" "unprognostic (6.61e-2)" "unprognostic (1.81e-1)" "unprognostic (1.80e-3)" 0.1 0.1 0.2 0.0 0.2 0.2 0.1 0.8 0.3 0.3 0.0 0.1 0.0 0.1 0.0 0.1 0.2 0.0 0.1 0.2 0.2 0.1 0.1 0.1 0.1 0.2 0.0 0.2 0.1 0.0 0.2 0.0 0.2 0.2 0.0 23.1 0.1 0.0 0.5 0.5 0.1 0.0 0.0 0.1 0.1 0.1 0.4 0.0 0.1 0.0 0.0 0.2 0.2 0.5 0.0 0.1 0.0 0.2 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.8 0.3 0.2 0.2 0.2 0.0 0.2 0.0 0.4 0.5 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.3 0.0 0.0 0.0 56.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 1.0 0.0 0.7 0.0 0.5 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.2 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 PDE6D JBTS22 ENSG00000156973 "Phosphodiesterase 6D" O43924 2 231732433-231786272 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Sensory transduction, Vision" "Ciliopathy, Joubert syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 211.9;Late spermatids: 147.9;Spermatocytes: 236.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037433, HPA037434" Uncertain NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA037433: AB_2675475, HPA037434: AB_10672490" "unprognostic (1.95e-1)" "unprognostic (2.33e-2)" "unprognostic (1.22e-1)" "unprognostic (7.72e-3)" "unprognostic (7.07e-2)" "unprognostic (5.41e-2)" "unprognostic (1.15e-1)" "unprognostic (9.48e-2)" "unprognostic (3.91e-1)" "unprognostic (1.41e-1)" "unprognostic (1.69e-1)" "unprognostic (4.75e-2)" "prognostic unfavorable (4.02e-5)" "unprognostic (1.11e-2)" "unprognostic (1.80e-2)" "unprognostic (1.46e-1)" "prognostic favorable (4.97e-4)" 16.8 28.1 43.4 16.2 47.3 14.6 16.3 47.4 50.7 19.2 38.0 19.6 13.4 17.6 14.9 16.3 15.5 14.2 19.3 44.4 45.7 19.5 15.4 15.2 23.3 45.6 46.0 13.4 13.2 23.5 25.0 23.0 45.7 13.7 17.6 69.6 14.2 17.6 13.7 16.4 15.7 22.0 46.5 18.8 16.2 27.8 45.8 32.4 14.0 16.7 24.0 17.9 16.4 49.6 26.3 20.3 37.0 28.2 43.7 36.1 15.7 27.0 44.6 40.8 56.9 8.1 24.5 21.4 22.7 23.2 74.9 20.4 22.3 30.2 52.6 63.5 26.4 31.2 12.4 13.0 20.2 20.6 17.2 25.5 26.4 39.8 30.4 27.5 44.1 68.3 9.1 23.5 27.5 52.0 67.7 64.4 28.6 39.6 28.1 45.7 17.0 32.9 42.8 19.5 36.4 32.6 23.0 19.4 46.3 36.1 17.5 43.0 19.5 26.5 7.3 57.9 21.4 57.9 26.3 52.6 27.4 38.6 42.5 84.4 48.2 68.4 46.3 48.7 36.3 50.4 46.0 47.3 49.3 55.5 31.7 44.3 42.0 34.4 64.9 55.8 84.4 43.1 43.4 47.3 47.4 50.7 44.4 45.7 45.6 46.0 45.7 46.5 45.8 49.6 20.8 0.0 8.7 18.3 19.5 13.8 12.4 23.6 21.1 14.7 13.3 17.7 13.1 12.8 15.8 12.9 16.7 16.4 18.2 10.2 25.4 23.1 211.9 6.8 9.2 19.6 17.4 15.8 13.4 23.9 21.9 14.7 13.3 6.5 14.5 7.3 19.2 5.0 18.9 11.8 18.1 10.0 14.2 14.4 15.1 147.9 13.1 17.5 23.2 16.9 24.6 22.0 17.5 48.7 34.0 26.0 14.9 12.4 17.0 10.5 11.2 18.4 11.8 29.0 19.7 10.7 24.9 236.8 65.1 20.3 14.2 13.5 18.5 11.5 10.5 11.0 PDE6G "PDEG, RP57" ENSG00000185527 "Phosphodiesterase 6G" P18545 17 81650459-81663112 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Sensory transduction, Vision" Hydrolase "Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 99 "retina: 2050.3" "Cell type enriched" "Detected in many" 6 "Rod photoreceptor cells: 4448.6" "Cancer enhanced" "Detected in many" "testis cancer: 10.6" "Not detected" "Not detected" "Group enriched" "Detected in many" 6 "basophil: 127.0;NK-cell: 220.2" "Group enriched" "Detected in all" 6 "granulocytes: 127.0;NK-cells: 220.2" "Cell line enhanced" "Detected in some" "Hep G2: 5.2;NB-4: 5.8;NTERA-2: 8.9;REH: 11.9;SuSa: 6.2" "Region enhanced" "Detected in some" "hippocampal formation: 4.7" "Not detected" "Not detected" HPA045118 Supported Uncertain Vesicles NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 79: Retina - Phototransduction" "Cluster 5: NTERA-2 - Transcription" "Cluster 46: Photoreceptor cells - Phototransduction" Vesicles "HPA045118: AB_2732517" "unprognostic (6.16e-2)" "unprognostic (1.95e-2)" "unprognostic (2.83e-2)" "unprognostic (3.51e-3)" "unprognostic (1.68e-1)" "unprognostic (1.46e-2)" "unprognostic (6.33e-2)" "unprognostic (3.80e-2)" "unprognostic (1.10e-2)" "unprognostic (1.02e-1)" "unprognostic (4.85e-2)" "unprognostic (5.01e-2)" "unprognostic (1.94e-2)" "unprognostic (5.71e-2)" "unprognostic (5.44e-2)" "unprognostic (2.73e-1)" "unprognostic (1.14e-1)" 1.5 0.3 0.0 4.7 0.1 7.8 0.9 0.2 0.5 1.0 0.2 1.6 0.6 0.2 0.1 0.8 0.7 2.5 0.4 0.1 0.7 2.1 4.2 3.0 20.6 0.1 0.2 0.0 0.0 0.1 0.1 12.0 0.2 0.2 1.0 2050.3 0.5 0.4 1.2 0.3 1.6 0.9 0.1 19.9 1.7 0.8 0.3 8.3 0.4 0.3 7.1 3.0 0.1 0.2 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.5 0.0 0.0 0.3 0.1 0.2 0.0 0.9 0.0 0.0 0.0 0.0 5.2 0.8 0.0 0.2 0.0 0.0 0.0 0.0 0.4 2.8 0.2 0.1 0.2 0.4 0.3 0.0 5.8 8.9 0.0 0.0 11.9 0.0 1.9 0.0 0.0 0.0 0.2 0.0 0.1 0.1 6.2 0.1 0.8 1.2 0.2 0.0 0.0 0.1 0.1 0.6 0.9 0.4 3.1 0.1 127.0 18.1 30.5 4.1 26.2 1.3 2.7 0.8 2.3 28.9 5.1 2.1 7.4 2.4 220.2 15.5 2.9 0.1 13.5 0.0 0.1 0.2 0.5 0.1 0.7 0.1 0.2 0.2 0.1 0.3 0.2 0.3 0.0 0.6 0.3 1.1 0.9 0.0 0.0 0.6 422.5 0.3 0.4 0.2 0.0 0.0 5.5 517.1 0.2 4.3 0.1 1.9 0.4 0.8 1.5 0.3 27.2 0.0 1.7 0.2 0.2 0.4 0.2 0.0 0.5 23.6 0.1 2.9 0.2 22.6 262.5 0.1 0.2 0.0 4.8 8.0 2.3 0.0 4.4 3.6 0.0 13.3 709.0 11.3 0.0 0.1 0.2 0.0 0.0 0.8 0.1 0.1 1.0 0.0 4448.6 0.0 0.1 0.1 1.1 0.2 0.3 1.4 0.3 1.7 2.1 0.0 0.1 PDE6H ENSG00000139053 "Phosphodiesterase 6H" Q13956 12 14973042-14981865 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Sensory transduction, Vision" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 226 "retina: 911.3" "Group enriched" "Detected in some" 6 "Cone photoreceptor cells: 831.9;Rod photoreceptor cells: 218.8" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "AN3-CA: 1.0" "Low region specificity" "Detected in single" HPA045118 Supported Uncertain Vesicles NA NA "Cluster 79: Retina - Phototransduction" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 9: Photoreceptor cells - Phototransduction" Vesicles "HPA045118: AB_2732517" "unprognostic (1.47e-3)" "unprognostic (1.07e-2)" 0.0 0.4 0.3 0.0 0.4 4.0 0.0 0.1 1.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 2.3 0.0 0.0 0.1 0.0 0.3 0.4 0.0 0.0 0.0 0.0 0.9 0.5 0.0 0.0 911.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.2 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.4 0.1 1.0 0.3 2.3 0.3 0.4 0.5 0.2 0.3 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 62.9 0.0 0.0 0.1 0.0 0.0 0.0 831.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.5 0.0 0.0 0.5 0.0 21.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.9 23.5 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.5 0.0 0.0 0.6 81.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 218.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 PDE7A HCP1 ENSG00000205268 "Phosphodiesterase 7A" Q13946 8 65714334-65842322 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 108.3" "Cell type enhanced" "Detected in many" "Excitatory neurons: 102.4;Inhibitory neurons: 111.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "Karpas-707: 94.9;MOLT-4: 167.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB018770, HPA027340" Approved NA NA "Cluster 30: Non-specific - Translation" "Cluster 3: T-cells - Adaptive immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" "CAB018770: AB_677329, HPA027340: AB_1855127" "unprognostic (2.76e-1)" "unprognostic (2.94e-2)" "unprognostic (1.36e-1)" "unprognostic (1.17e-2)" "unprognostic (2.15e-1)" "unprognostic (7.11e-2)" "prognostic unfavorable (5.64e-4)" "unprognostic (1.44e-2)" "unprognostic (6.94e-2)" "unprognostic (1.54e-1)" "unprognostic (1.76e-2)" "unprognostic (1.56e-1)" "prognostic unfavorable (1.35e-4)" "unprognostic (3.08e-2)" "unprognostic (1.26e-1)" "unprognostic (5.06e-2)" "unprognostic (2.03e-2)" 8.5 3.1 5.2 28.5 8.0 26.6 19.8 8.5 7.2 13.4 7.7 7.6 11.4 6.3 14.0 6.6 7.9 11.5 49.3 5.1 5.3 18.8 5.5 19.1 58.8 6.6 5.2 6.0 14.3 3.1 13.4 8.3 5.2 13.7 9.8 14.0 20.8 8.6 63.6 8.2 26.4 5.5 3.9 29.4 13.0 10.3 8.2 108.3 22.9 75.9 43.0 9.9 8.9 11.1 12.5 10.8 47.2 22.2 6.7 5.8 20.0 9.3 7.9 11.5 11.0 12.8 8.1 35.0 2.2 5.8 10.2 13.8 17.5 19.7 12.0 41.3 8.9 25.6 18.5 9.6 3.4 20.3 9.8 8.3 32.0 7.4 22.3 9.9 11.4 84.0 19.1 94.9 7.9 6.8 167.6 23.0 50.3 10.1 4.8 61.8 7.2 9.2 7.8 24.6 22.9 26.5 9.8 4.9 4.8 32.2 26.1 52.2 7.4 15.9 19.6 11.3 7.6 45.6 21.3 60.3 16.1 42.1 8.9 2.5 0.7 5.5 3.4 0.6 5.5 6.5 5.2 3.4 1.5 7.5 11.9 9.2 2.5 2.3 0.2 2.1 4.7 1.8 5.2 8.0 8.5 7.2 5.1 5.3 6.6 5.2 5.2 3.9 8.2 11.1 8.6 19.2 22.7 41.4 95.1 18.1 13.6 8.8 7.4 27.3 23.1 21.8 46.6 20.0 17.3 3.7 56.3 14.1 93.4 3.7 0.0 8.2 32.1 11.8 12.6 7.9 9.6 31.6 102.4 5.3 8.4 17.2 8.2 13.5 9.5 14.2 6.8 4.3 10.4 18.5 111.3 6.5 12.2 17.3 34.9 15.0 7.5 26.2 16.0 48.7 19.7 10.1 47.4 89.0 86.2 6.1 5.6 7.5 56.3 19.4 5.9 21.3 20.3 66.1 0.0 18.4 11.1 10.3 10.9 6.0 18.8 8.6 81.3 6.8 6.5 10.8 PDE7B ENSG00000171408 "Phosphodiesterase 7B" Q9NP56 6 135851701-136195574 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 22.1" "Cell type enhanced" "Detected in many" "Astrocytes: 346.4;Excitatory neurons: 136.7;Inhibitory neurons: 166.0;Oligodendrocyte precursor cells: 343.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "naive B-cell: 1.3" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "ASC diff: 8.7;ASC TERT1: 10.2;EFO-21: 16.2;HeLa: 9.6;HSkMC: 22.4;HUVEC TERT2: 10.8;U-2197: 11.4" "Region enriched" "Detected in all" 5 "basal ganglia: 125.3" "Low region specificity" "Detected in all" HPA023967 Uncertain Approved Nucleoplasm No NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 80: Striated muscle - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA023967: AB_1855128" "unprognostic (3.18e-1)" "unprognostic (3.47e-1)" "unprognostic (2.34e-1)" "unprognostic (1.79e-3)" "unprognostic (3.34e-1)" "unprognostic (3.22e-4)" "unprognostic (1.37e-2)" "unprognostic (3.00e-1)" "unprognostic (2.80e-1)" "unprognostic (6.73e-3)" "unprognostic (1.11e-2)" "unprognostic (7.85e-2)" "prognostic favorable (1.59e-4)" "unprognostic (3.14e-3)" "unprognostic (2.68e-2)" "unprognostic (1.43e-1)" "unprognostic (3.34e-2)" 5.2 2.3 6.5 2.2 22.1 0.1 2.6 3.6 8.1 3.9 2.8 2.5 1.9 7.8 2.2 1.3 2.8 3.4 6.6 2.6 8.7 5.5 3.7 1.7 1.5 6.2 11.6 13.0 0.8 6.2 4.8 1.0 6.0 4.3 2.7 2.4 2.9 10.3 4.7 0.8 2.2 7.6 4.6 1.1 3.6 1.5 15.8 3.8 4.7 8.9 0.8 6.0 3.6 2.8 0.0 5.7 0.2 0.0 8.7 10.2 0.1 0.5 2.9 2.1 1.1 0.0 0.1 0.1 16.2 3.6 0.0 0.0 0.0 0.0 0.7 0.0 0.2 0.0 9.6 0.0 3.7 0.1 0.0 22.4 0.0 4.2 0.0 0.9 10.8 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.8 3.8 0.7 3.9 3.7 0.1 0.2 0.0 0.0 1.8 0.0 2.3 0.0 11.4 0.0 0.1 0.0 0.0 0.6 0.0 0.9 0.0 0.3 0.2 0.0 0.0 0.0 0.4 0.1 0.0 0.8 1.3 0.5 0.3 0.0 0.2 0.0 0.0 0.0 0.1 6.5 22.1 3.6 8.1 2.6 8.7 6.2 11.6 6.0 4.6 15.8 2.8 8.3 0.0 0.5 346.4 11.9 0.4 0.3 0.5 0.0 4.4 0.9 0.4 8.4 2.8 0.2 22.0 0.0 0.1 0.7 0.1 0.0 0.2 0.5 3.1 1.4 23.1 7.3 0.8 136.7 1.6 0.0 9.8 4.6 2.1 10.2 31.1 35.3 3.8 0.3 6.7 166.0 0.0 0.0 1.9 4.8 0.9 12.2 3.2 0.0 70.3 0.7 11.5 0.0 343.8 10.4 0.1 0.0 7.9 0.2 0.4 0.0 1.6 1.6 0.9 13.1 30.6 9.1 0.3 0.1 0.2 1.4 0.0 2.9 4.4 0.0 0.3 PDE8A HsT19550 ENSG00000073417 "Phosphodiesterase 8A" O60658 15 84980440-85139145 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in many" 7 "Oligodendrocytes: 968.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "RT4: 89.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007722 Approved Approved "Golgi apparatus" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 45: Intestine - Brush border" "Cluster 15: RT4 - Unknown function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Golgi apparatus" "HPA007722: AB_1855130" "unprognostic (1.68e-1)" "unprognostic (2.83e-2)" "unprognostic (4.81e-2)" "unprognostic (4.97e-2)" "unprognostic (6.25e-2)" "unprognostic (3.47e-2)" "unprognostic (2.97e-2)" "unprognostic (3.94e-2)" "unprognostic (1.03e-1)" "unprognostic (2.45e-1)" "unprognostic (8.99e-3)" "unprognostic (2.75e-2)" "unprognostic (3.42e-1)" "unprognostic (3.72e-1)" "unprognostic (4.26e-1)" "unprognostic (1.31e-1)" "unprognostic (1.94e-2)" 16.7 16.6 20.9 8.5 32.3 3.3 10.5 21.9 22.4 11.6 15.2 24.0 15.3 9.1 7.3 6.4 9.0 15.8 8.0 17.3 20.1 24.3 30.0 10.8 5.6 23.8 28.5 12.7 14.5 16.9 6.7 11.4 23.6 6.9 21.9 14.5 6.4 9.6 5.8 6.3 13.6 10.6 19.5 6.3 11.0 11.0 26.9 4.6 12.3 6.5 5.1 17.7 7.0 45.2 29.0 48.4 7.9 5.4 32.7 17.2 9.6 19.4 21.1 16.6 18.9 10.9 16.9 5.8 14.6 25.9 19.7 20.2 33.8 14.9 22.0 10.8 20.2 7.7 30.3 15.6 23.5 4.5 11.3 17.4 9.1 19.6 18.6 14.3 21.6 6.4 15.6 18.3 15.2 24.5 2.6 4.5 3.8 9.5 8.6 3.6 6.5 8.1 13.2 89.0 18.3 14.1 18.9 20.3 55.5 8.7 6.7 8.7 17.1 38.4 13.6 13.9 31.6 8.9 16.7 6.2 26.1 18.1 11.0 0.0 0.9 0.6 0.3 0.7 0.6 0.2 0.5 0.6 0.5 0.3 0.7 0.3 0.0 0.2 1.6 0.0 1.1 0.2 20.9 32.3 21.9 22.4 17.3 20.1 23.8 28.5 23.6 19.5 26.9 45.2 30.7 6.4 26.5 83.9 14.8 11.3 11.1 13.9 18.2 13.0 6.6 5.2 6.8 41.5 15.4 7.3 12.5 8.0 5.5 58.7 7.9 11.3 6.4 12.5 21.6 24.3 14.5 0.8 60.8 9.6 7.1 16.2 26.5 20.6 22.1 17.9 14.3 23.3 10.8 10.1 126.2 19.0 4.1 12.3 18.9 5.6 10.8 19.2 10.6 85.3 9.0 2.6 10.3 119.1 968.6 11.5 31.8 11.3 7.2 25.4 22.1 21.1 10.5 31.2 39.5 17.8 24.5 25.6 17.3 7.5 10.4 4.5 10.8 25.3 28.5 26.4 PDE8B ENSG00000113231 "Phosphodiesterase 8B" O95263 5 77210449-77428256 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Cushing syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "thyroid gland: 124.7" "Cell type enhanced" "Detected in many" "Astrocytes: 64.9;Excitatory neurons: 183.1;Horizontal cells: 69.0;Inhibitory neurons: 276.5;Muller glia cells: 86.5;Oligodendrocyte precursor cells: 190.5" "Cancer enriched" "Detected in many" 6 "thyroid cancer: 35.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ hTERT+: 13.6;HeLa: 34.8;SK-BR-3: 11.1" "HPA036911, HPA036912" Supported Approved Nucleoplasm,Cytosol NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 7: Kidney - Transmembrane transport" "Cluster 20: HeLa - Mitochondria" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Cytosol" "HPA036911: AB_2675378, HPA036912: AB_10670377" "unprognostic (1.30e-1)" "unprognostic (7.95e-2)" "unprognostic (3.35e-2)" "unprognostic (7.61e-4)" "unprognostic (1.59e-2)" "unprognostic (1.41e-1)" "unprognostic (2.66e-2)" "unprognostic (4.48e-2)" "unprognostic (1.71e-1)" "unprognostic (3.26e-2)" "unprognostic (3.98e-2)" "unprognostic (2.44e-1)" "unprognostic (9.04e-3)" "unprognostic (3.40e-2)" "unprognostic (3.76e-2)" "unprognostic (1.98e-1)" "unprognostic (3.19e-2)" 20.9 4.8 24.2 1.0 28.6 0.4 14.0 4.8 24.6 17.4 0.0 5.6 2.0 26.4 6.3 2.0 28.7 4.3 23.7 25.5 32.5 15.6 2.3 5.2 1.2 20.5 15.9 4.2 7.9 0.8 12.5 23.8 18.8 19.0 1.2 22.5 10.5 11.9 0.7 2.0 3.3 17.7 9.9 0.8 5.5 3.0 36.7 0.3 124.7 0.8 1.0 4.0 4.9 17.2 0.1 4.9 0.8 0.3 1.5 0.0 0.5 1.5 13.6 0.2 0.1 1.4 0.1 0.3 0.1 0.1 0.2 0.6 0.2 0.0 0.2 0.2 0.7 0.4 34.8 0.3 0.0 0.4 0.5 0.8 0.0 0.0 0.0 0.4 0.0 0.5 0.1 0.2 0.0 0.2 0.5 0.8 0.8 0.2 0.1 0.6 0.9 0.4 0.0 0.2 5.4 1.0 2.3 11.1 0.7 0.7 1.8 0.9 0.5 0.3 0.3 0.2 0.5 0.7 0.5 0.4 1.2 0.5 0.3 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 24.2 28.6 4.8 24.6 25.5 32.5 20.5 15.9 18.8 9.9 36.7 17.2 0.8 3.2 2.8 64.9 0.3 0.4 2.0 0.1 0.0 10.8 5.8 3.0 28.0 2.8 1.6 1.8 54.2 0.0 0.2 0.1 0.0 2.3 6.8 15.3 2.1 4.5 4.9 0.0 183.1 0.0 0.1 3.8 0.0 7.9 1.3 1.8 2.9 0.1 0.4 69.0 276.5 1.0 0.0 1.0 1.6 5.1 5.9 0.9 1.8 10.3 0.1 86.5 0.0 190.5 45.5 0.2 0.4 0.0 0.3 29.1 0.2 0.7 0.7 5.8 6.6 1.8 7.7 1.1 2.6 0.5 1.1 0.0 0.1 8.8 1.2 4.2 PDE9A ENSG00000160191 "Phosphodiesterase 9A" O76083 21 42653621-42775509 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 74.7" "Cell type enhanced" "Detected in many" "Distal enterocytes: 90.8;Paneth cells: 105.3;Proximal enterocytes: 233.5" "Cancer enriched" "Detected in all" 5 "prostate cancer: 31.5" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "naive CD4 T-cell: 3.1" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "AF22: 29.7;EFO-21: 30.0;MCF7: 23.2;NB-4: 34.7;NTERA-2: 41.2;SCLC-21H: 22.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA011380, HPA011978" Enhanced Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 38: EFO-21 - Unknown function" "Cluster 45: Enterocytes - Digestion" Cytosol "Nucleoplasm, Plasma membrane" "HPA011380: AB_1855132, HPA011978: " "unprognostic (5.75e-2)" "unprognostic (9.92e-3)" "unprognostic (3.50e-1)" "unprognostic (1.08e-1)" "unprognostic (1.44e-1)" "unprognostic (1.40e-1)" "unprognostic (5.06e-2)" "unprognostic (3.99e-2)" "unprognostic (6.02e-2)" "unprognostic (1.60e-1)" "unprognostic (1.25e-2)" "unprognostic (5.01e-2)" "unprognostic (1.90e-2)" "unprognostic (4.01e-3)" "unprognostic (1.97e-1)" "unprognostic (6.55e-2)" "unprognostic (1.79e-1)" 9.4 11.1 12.3 3.9 15.1 0.5 10.8 14.0 12.9 7.2 8.6 74.7 2.9 5.1 19.4 3.7 10.6 6.8 4.3 10.6 12.6 29.8 4.2 4.9 4.8 12.4 14.4 3.5 4.1 6.5 9.9 10.3 12.7 38.5 16.4 10.7 12.7 15.8 2.4 7.0 47.3 8.8 11.0 18.3 13.4 1.9 15.0 7.8 6.5 4.8 3.1 18.9 6.2 12.0 0.0 2.8 29.7 3.7 0.0 0.8 0.5 0.0 0.0 0.0 0.0 3.2 18.2 0.0 30.0 0.0 2.2 0.0 2.7 9.8 0.0 0.0 10.4 0.0 0.0 6.4 2.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.5 0.0 0.0 23.2 1.5 34.7 41.2 14.6 0.0 0.0 0.0 1.2 20.4 7.6 22.5 13.5 5.2 0.0 0.5 7.0 0.2 19.1 0.0 0.0 4.4 0.0 0.0 0.0 0.0 0.0 0.0 12.4 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.9 0.2 0.1 0.2 3.1 0.6 0.4 0.9 0.0 0.4 1.0 0.3 12.3 15.1 14.0 12.9 10.6 12.6 12.4 14.4 12.7 11.0 15.0 12.0 18.6 3.2 5.0 43.4 1.6 1.0 10.9 4.2 6.2 26.4 13.4 12.6 1.6 5.7 2.4 18.4 0.0 0.0 1.0 90.8 29.4 7.3 0.6 18.1 8.5 11.9 13.1 3.2 5.6 2.4 0.1 5.9 1.5 26.8 1.3 6.1 5.7 0.9 7.5 35.3 10.8 25.8 8.2 1.3 0.8 2.2 11.8 1.6 28.4 31.9 1.1 11.0 0.0 29.1 16.6 5.3 105.3 6.0 0.2 28.1 233.5 8.9 1.3 2.8 13.1 0.5 6.4 0.4 2.3 0.5 0.6 0.4 3.8 16.9 24.4 15.0 PNP "NP, PUNP" ENSG00000198805 "Purine nucleoside phosphorylase" P00491 14 20468954-20477089 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Purine salvage" "Glycosyltransferase, Transferase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 333.9;epididymis: 594.8" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 360.6;Erythroid cells: 227.3;Syncytiotrophoblasts: 646.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HL-60: 531.3;U-937: 593.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA001625 Enhanced Supported Cytosol NA NA 58000000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 32: U-937 - Innate immune response" "Cluster 47: Cytotrophoblasts - Unknown function" Cytosol "HPA001625: AB_1854577" "unprognostic (1.20e-3)" "unprognostic (2.68e-2)" "unprognostic (1.04e-2)" "unprognostic (1.70e-1)" "unprognostic (3.10e-1)" "unprognostic (7.06e-2)" "prognostic unfavorable (4.43e-4)" "unprognostic (4.94e-3)" "unprognostic (3.87e-2)" "unprognostic (7.45e-2)" "unprognostic (1.85e-2)" "unprognostic (2.21e-1)" "prognostic favorable (2.24e-4)" "unprognostic (1.69e-1)" "unprognostic (7.54e-2)" "unprognostic (2.46e-1)" "unprognostic (1.64e-3)" 78.6 24.8 16.1 46.8 16.6 333.9 34.6 22.6 22.7 25.3 18.9 52.2 120.3 14.2 594.8 87.4 18.2 56.8 29.0 17.7 19.6 206.8 98.0 48.6 46.7 20.3 18.1 5.0 23.2 32.0 19.8 132.6 20.1 15.0 61.8 27.1 22.6 27.4 7.3 29.6 60.3 38.7 23.1 44.5 50.6 7.4 21.1 33.5 17.8 10.0 64.4 100.4 41.5 20.1 86.1 113.4 24.0 53.9 26.0 21.0 71.8 85.2 40.3 68.2 67.0 66.1 76.5 227.1 96.8 45.5 81.5 89.9 125.2 159.8 89.5 75.0 109.6 189.1 89.9 109.3 24.2 531.3 94.7 14.4 57.4 206.0 91.0 37.8 295.9 141.0 95.4 137.4 86.7 79.1 157.6 311.3 67.5 215.7 186.1 130.2 35.9 88.3 243.7 79.6 101.9 22.6 163.4 205.0 13.2 32.6 75.5 92.5 240.0 46.1 62.6 105.1 148.4 63.1 113.3 258.9 39.3 593.0 4.6 12.0 30.6 10.3 39.8 27.3 73.6 25.7 44.2 45.0 48.1 28.8 27.6 35.9 3.7 38.5 26.6 27.3 16.7 31.1 16.1 16.6 22.6 22.7 17.7 19.6 20.3 18.1 20.1 23.1 21.1 20.1 149.6 0.0 23.5 5.9 50.3 84.6 67.4 12.6 112.7 4.7 56.3 62.6 3.5 27.1 13.4 82.8 14.6 360.6 45.2 61.1 39.2 43.2 1.3 36.0 12.7 139.4 46.4 227.3 0.6 51.5 41.8 32.4 106.5 65.3 57.7 5.0 24.3 30.6 70.9 16.8 1.1 51.3 18.3 18.1 58.4 0.8 0.3 83.3 30.2 3.7 13.2 78.8 29.9 3.0 0.9 130.8 83.9 0.7 88.6 27.5 41.2 118.9 10.5 18.1 0.0 23.9 41.3 0.4 0.7 114.7 63.9 646.2 62.3 3.1 51.4 77.1 POLA1 "NSX, p180, POLA" ENSG00000101868 "DNA polymerase alpha 1, catalytic subunit" P09884 X 24693873-24996986 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "DNA replication, Host-virus interaction" "DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase" "Disease variant, Dwarfism, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 38.5;Excitatory neurons: 42.3;Inhibitory neurons: 65.7;Microglial cells: 57.1;Oligodendrocyte precursor cells: 59.3;Oligodendrocytes: 97.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002947, CAB012274" Supported Supported Nucleoplasm,Cytosol NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm Cytosol "CAB012274: , HPA002947: AB_1079652" "unprognostic (6.92e-2)" "unprognostic (4.43e-3)" "unprognostic (3.27e-3)" "unprognostic (1.53e-2)" "unprognostic (2.53e-1)" "unprognostic (1.49e-1)" "prognostic unfavorable (4.80e-5)" "unprognostic (1.87e-1)" "unprognostic (9.25e-3)" "unprognostic (2.48e-2)" "unprognostic (8.41e-2)" "unprognostic (7.42e-2)" "unprognostic (2.09e-1)" "unprognostic (1.44e-1)" "unprognostic (3.66e-2)" "unprognostic (3.48e-2)" "unprognostic (3.08e-1)" 3.7 2.0 1.9 4.8 2.5 7.3 5.1 2.2 1.8 4.3 0.8 4.1 2.4 4.2 1.4 3.9 3.7 2.1 3.5 1.3 1.9 2.9 2.0 3.1 6.8 2.3 2.3 5.8 2.8 3.4 1.8 5.6 2.4 3.1 5.2 3.7 3.0 3.5 4.9 4.0 3.5 4.8 2.2 3.5 3.7 2.6 2.1 11.9 3.1 3.1 7.7 3.7 3.8 2.6 32.7 24.6 30.3 24.1 5.2 6.5 6.9 23.6 12.7 25.0 28.3 20.4 17.0 41.1 7.7 9.6 23.4 26.0 59.7 18.7 33.6 21.1 24.8 31.0 42.8 13.5 2.4 41.6 15.5 4.1 3.6 31.2 8.4 5.8 13.0 20.8 28.7 20.0 16.8 22.4 45.2 7.2 30.7 20.3 19.1 39.0 81.5 30.7 7.1 21.1 27.9 16.7 28.1 11.2 11.6 33.0 25.7 11.5 10.1 21.3 14.9 42.4 22.6 11.6 18.1 32.7 12.4 18.3 24.9 0.0 0.2 0.2 0.6 1.4 0.8 1.0 0.8 1.0 0.7 0.4 0.4 0.5 0.0 0.8 0.2 0.2 0.9 0.5 1.9 2.5 2.2 1.8 1.3 1.9 2.3 2.3 2.4 2.2 2.1 2.6 5.8 9.6 6.5 38.5 5.2 2.8 4.6 1.8 5.7 3.9 4.7 4.3 11.8 0.0 7.2 1.8 2.1 6.1 3.2 2.5 3.9 3.2 0.2 3.2 4.7 6.3 4.2 24.2 42.3 3.0 4.9 4.6 4.6 3.8 9.5 8.3 3.3 3.4 4.4 1.7 65.7 4.2 4.1 4.4 1.5 1.7 6.2 4.5 0.0 57.1 3.7 4.8 5.2 59.3 97.7 1.4 1.2 3.4 8.6 2.0 2.3 1.6 6.1 7.4 6.6 9.2 6.0 6.4 4.5 5.5 2.3 2.3 4.9 5.0 4.2 2.4 POLA2 FLJ21662 ENSG00000014138 "DNA polymerase alpha 2, accessory subunit" Q14181 11 65261920-65305589 "Metabolic proteins, Predicted intracellular proteins" "DNA replication" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Erythroid cells: 23.2;Spermatocytes: 23.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" HPA037570 Supported Supported Nucleoplasm,Cytosol NA Yes "Cluster 44: Non-specific - Transcription" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm Cytosol "HPA037570: AB_10672280" "unprognostic (2.28e-1)" "prognostic favorable (4.61e-4)" "unprognostic (1.67e-2)" "unprognostic (7.44e-2)" "unprognostic (5.20e-2)" "unprognostic (3.18e-2)" "prognostic unfavorable (2.11e-6)" "unprognostic (1.14e-1)" "unprognostic (2.87e-2)" "unprognostic (1.15e-2)" "unprognostic (4.05e-2)" "unprognostic (1.83e-1)" "prognostic unfavorable (4.09e-8)" "unprognostic (1.60e-3)" "unprognostic (8.26e-2)" "unprognostic (8.16e-2)" "unprognostic (6.25e-3)" 3.3 2.6 1.9 5.3 2.9 6.9 3.5 4.8 3.3 4.5 1.7 5.3 3.6 5.0 3.3 4.5 3.8 1.8 2.9 1.9 1.5 3.5 3.7 3.5 10.0 4.5 2.8 5.1 3.3 3.2 1.9 2.1 3.7 3.0 4.9 3.6 4.2 3.1 3.1 5.1 4.2 4.1 3.1 5.7 3.8 5.2 2.6 15.9 3.3 3.4 13.2 3.2 3.2 7.0 32.6 21.9 47.3 20.4 3.7 3.6 19.5 25.6 15.9 64.4 43.3 6.9 24.0 48.1 20.4 11.0 35.5 18.9 38.8 25.1 61.1 21.3 14.7 32.4 39.4 10.4 0.9 33.5 25.6 3.7 2.9 47.4 8.5 10.3 14.6 20.2 30.2 25.3 44.4 34.9 62.6 13.2 38.6 16.1 16.2 33.4 29.9 40.7 14.1 21.8 32.5 18.1 14.9 15.9 7.9 29.7 28.6 14.1 3.9 25.4 18.7 19.8 16.0 12.0 14.7 45.0 14.9 18.8 33.7 10.0 5.2 2.3 3.8 3.2 4.5 3.9 4.2 4.2 7.4 3.9 3.5 3.1 1.4 3.8 1.7 5.9 4.6 5.3 1.9 2.9 4.8 3.3 1.9 1.5 4.5 2.8 3.7 3.1 2.6 7.0 2.6 0.0 3.4 1.0 5.1 1.7 4.2 5.7 2.2 2.2 3.0 2.3 2.9 7.2 3.7 5.5 2.1 15.6 4.3 3.0 3.9 5.3 2.7 1.8 2.9 3.7 3.0 23.2 4.3 3.4 19.0 7.7 5.6 2.5 0.0 11.0 5.3 2.1 9.7 3.3 3.6 3.5 2.0 2.8 3.7 4.0 7.5 5.3 0.0 12.2 8.0 2.2 5.2 1.5 8.7 4.9 2.2 7.5 10.4 3.4 1.7 2.0 3.2 5.4 6.6 19.6 5.0 23.7 17.7 4.3 1.4 7.3 5.5 4.0 6.3 3.7 POLB ENSG00000070501 "DNA polymerase beta" P06746 8 42338454-42371808 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication, DNA synthesis" "DNA-binding, DNA-directed DNA polymerase, Lyase, Nucleotidyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 254.5;Late spermatids: 133.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HMC-1: 280.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011616, HPA049104, HPA069013" Enhanced Uncertain Vesicles NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 3: HMC-1 - Innate immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Vesicles "CAB011616: AB_731977, HPA049104: AB_2680632, HPA069013: " "unprognostic (1.67e-1)" "unprognostic (2.68e-3)" "unprognostic (2.43e-1)" "prognostic unfavorable (1.46e-4)" "unprognostic (8.49e-2)" "unprognostic (2.64e-2)" "unprognostic (4.24e-2)" "unprognostic (1.02e-1)" "unprognostic (2.31e-2)" "unprognostic (1.99e-1)" "unprognostic (4.57e-2)" "unprognostic (4.77e-1)" "prognostic unfavorable (2.15e-5)" "unprognostic (1.06e-2)" "unprognostic (1.40e-1)" "unprognostic (4.22e-2)" "prognostic favorable (5.65e-4)" 12.4 17.5 26.6 13.5 27.4 51.3 27.4 82.3 35.5 18.9 24.3 12.3 10.8 12.9 19.7 26.5 13.2 17.4 26.1 28.1 29.0 18.0 33.9 14.2 20.2 27.1 27.8 20.4 16.9 18.8 26.7 11.1 28.9 24.8 13.2 18.0 30.3 11.3 85.3 23.1 10.8 10.6 27.6 17.2 14.0 53.1 30.2 24.8 14.2 70.0 22.2 30.8 18.9 28.9 40.2 23.5 40.6 80.4 21.8 20.7 33.8 25.2 29.3 41.5 37.7 33.1 46.0 36.4 31.1 16.5 43.4 20.0 34.1 29.5 50.3 23.8 36.7 26.5 18.2 45.3 34.1 18.6 280.6 18.8 34.4 30.1 35.4 51.8 32.1 77.2 58.4 22.4 40.3 23.6 78.0 52.6 54.4 48.4 26.7 44.2 40.8 31.4 78.4 32.1 22.7 41.8 29.9 19.9 79.0 41.4 52.5 31.5 17.8 19.1 27.0 48.8 24.6 32.5 58.4 52.2 19.3 39.4 52.2 47.6 15.1 48.1 12.0 18.8 13.3 12.2 12.5 13.0 15.7 11.1 14.1 13.3 63.6 22.2 26.3 84.9 19.3 11.5 26.6 27.4 82.3 35.5 28.1 29.0 27.1 27.8 28.9 27.6 30.2 28.9 13.9 3.2 13.6 6.8 20.2 16.8 30.1 14.2 31.3 2.9 14.3 15.1 21.6 7.2 20.7 7.3 8.4 7.5 51.9 3.1 5.9 11.7 254.5 13.8 7.7 12.5 6.0 7.6 15.8 9.6 7.0 9.7 10.2 9.9 23.4 12.7 8.6 12.7 7.4 6.7 20.3 5.4 4.1 5.7 9.9 133.9 7.2 18.2 7.2 19.7 11.2 8.3 13.4 12.5 16.7 33.6 5.8 3.8 21.9 41.6 4.3 6.8 16.4 4.4 0.0 6.6 12.3 19.4 15.4 27.3 20.0 11.1 16.2 7.8 6.6 31.6 POLD1 "CDC2, POLD" ENSG00000062822 "DNA polymerase delta 1, catalytic subunit" P28340 19 50384204-50418018 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA excision, DNA repair, DNA replication" "DNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Paneth cells: 51.3;Spermatogonia: 25.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004375, HPA046524" Supported Supported Nucleoplasm NA NA "Cluster 37: B-cells - Transcription" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "CAB004375: AB_675487, HPA046524: AB_2679684" "unprognostic (2.45e-1)" "unprognostic (7.02e-3)" "unprognostic (1.59e-1)" "unprognostic (4.35e-2)" "unprognostic (2.55e-1)" "unprognostic (1.85e-2)" "prognostic unfavorable (2.87e-6)" "unprognostic (4.12e-2)" "unprognostic (1.16e-2)" "unprognostic (2.83e-1)" "unprognostic (5.08e-1)" "unprognostic (3.92e-3)" "unprognostic (4.01e-3)" "unprognostic (1.28e-2)" "unprognostic (1.61e-1)" "unprognostic (2.89e-1)" "unprognostic (3.70e-2)" 5.6 5.1 3.2 9.2 3.7 26.3 6.3 4.5 3.8 7.6 2.5 8.9 5.4 8.4 0.4 10.7 6.5 2.1 5.8 2.7 2.7 6.5 6.4 9.5 11.2 5.1 3.7 7.1 7.9 2.3 4.7 5.9 4.1 6.1 2.2 1.9 7.4 2.6 5.6 9.2 10.1 2.3 3.5 12.8 6.2 13.3 4.1 11.0 9.8 1.5 5.2 5.9 7.7 4.4 52.1 77.9 27.9 22.4 3.0 2.8 45.6 34.0 9.6 30.0 34.9 42.4 39.2 84.6 19.4 7.1 13.9 45.1 27.4 25.1 6.8 64.4 145.0 66.1 73.0 54.6 3.7 67.0 57.7 6.4 7.1 26.1 6.5 6.0 14.2 58.2 77.4 54.3 9.1 40.6 92.2 110.6 48.7 25.3 55.4 105.4 62.2 67.7 7.4 44.9 39.3 38.6 33.0 35.9 8.8 10.1 21.1 50.7 17.4 21.4 70.7 22.0 56.5 60.0 91.3 76.3 21.2 66.9 20.8 1.3 4.3 1.5 4.3 5.6 4.0 6.0 4.0 3.5 3.9 5.4 4.0 3.9 0.6 4.2 6.9 7.1 3.1 4.0 3.2 3.7 4.5 3.8 2.7 2.7 5.1 3.7 4.1 3.5 4.1 4.4 3.5 3.2 3.9 0.7 8.7 6.4 2.3 3.5 3.4 4.0 4.3 5.3 3.4 2.8 3.8 3.7 6.2 19.2 3.8 12.2 0.0 4.8 1.9 2.8 1.6 3.4 7.2 15.2 1.2 4.0 15.0 4.1 3.1 3.0 0.0 9.5 1.1 2.2 15.1 0.0 0.9 7.4 0.0 5.7 5.3 1.9 3.1 5.8 5.4 1.0 4.8 1.2 6.2 1.5 2.2 4.7 51.3 5.3 10.6 2.8 6.3 2.8 3.0 4.3 0.0 3.5 4.0 11.5 25.6 5.5 5.3 7.7 5.4 3.4 14.3 1.3 POLD2 ENSG00000106628 "DNA polymerase delta 2, accessory subunit" P49005 7 44114680-44124358 "Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA excision, DNA repair, DNA replication" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 288.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026745 Approved Enhanced Nucleoplasm NA NA "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm "HPA026745: AB_1855520" "unprognostic (9.09e-2)" "unprognostic (1.41e-1)" "unprognostic (9.89e-2)" "unprognostic (1.84e-3)" "unprognostic (1.55e-1)" "unprognostic (2.10e-3)" "unprognostic (1.50e-3)" "unprognostic (4.94e-3)" "unprognostic (8.17e-2)" "unprognostic (1.01e-3)" "unprognostic (4.53e-2)" "unprognostic (1.12e-1)" "unprognostic (3.72e-2)" "unprognostic (2.14e-1)" "unprognostic (5.18e-2)" "unprognostic (1.03e-1)" "unprognostic (4.44e-3)" 48.4 58.8 48.9 35.0 46.7 44.6 44.4 46.4 53.8 53.4 52.0 39.0 32.4 47.3 14.0 86.6 75.8 18.5 86.8 46.5 47.6 51.6 113.5 36.2 36.9 49.0 49.3 59.3 73.4 62.0 53.0 27.1 49.3 46.8 28.9 22.6 46.6 30.1 118.8 59.9 32.9 32.4 46.9 35.9 48.0 48.7 56.7 46.2 40.6 77.5 33.4 48.2 54.3 45.6 162.2 209.3 114.1 240.5 99.5 105.5 112.9 97.2 97.5 130.6 97.4 178.0 151.4 371.1 121.2 141.1 261.0 218.3 188.9 265.6 84.4 105.9 222.1 82.2 216.3 152.3 112.8 253.4 96.1 96.8 159.6 202.4 195.1 136.3 110.7 245.8 305.4 173.2 146.3 262.7 310.5 476.0 180.0 231.0 203.0 206.4 153.4 528.9 114.0 102.7 225.0 176.2 121.5 430.6 83.7 73.5 249.7 321.6 88.0 171.7 215.8 213.3 310.5 269.3 430.3 359.1 154.1 252.7 248.6 1.7 41.2 10.4 51.6 38.9 77.3 82.2 61.7 52.5 70.8 80.2 81.4 60.5 3.3 44.9 38.8 112.7 54.1 69.7 48.9 46.7 46.4 53.8 46.5 47.6 49.0 49.3 49.3 46.9 56.7 45.6 25.6 6.4 31.8 11.8 35.3 49.3 83.0 111.8 42.7 41.6 57.1 62.7 58.2 44.3 54.1 29.5 31.3 69.9 24.3 31.0 103.7 71.9 108.9 53.5 52.4 33.6 41.9 52.2 5.0 59.5 84.1 49.3 40.2 24.9 26.6 65.6 19.2 95.6 46.8 53.8 5.1 53.6 30.5 14.4 26.6 288.0 41.7 15.0 49.8 4.7 13.0 58.1 18.6 5.0 7.8 44.5 25.0 53.4 38.0 127.6 10.0 95.2 69.7 52.0 19.7 55.4 78.6 48.2 52.4 70.5 60.5 35.4 25.7 103.9 81.5 71.3 POLD3 "KIAA0039, P66, P68, PPP1R128" ENSG00000077514 "DNA polymerase delta 3, accessory subunit" Q15054 11 74493851-74669117 "Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA excision, DNA repair, DNA replication" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" HPA058846 Enhanced Supported Nucleoplasm NA Yes "Cluster 14: Monocytes - Unknown function" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm "HPA058846: AB_2683833" "unprognostic (3.68e-1)" "unprognostic (3.22e-2)" "unprognostic (2.05e-3)" "unprognostic (3.28e-1)" "unprognostic (1.74e-1)" "unprognostic (3.49e-1)" "prognostic unfavorable (9.17e-4)" "unprognostic (1.08e-1)" "prognostic unfavorable (5.48e-4)" "unprognostic (3.99e-3)" "unprognostic (1.54e-3)" "unprognostic (9.21e-3)" "prognostic unfavorable (7.90e-6)" "unprognostic (7.92e-3)" "unprognostic (2.65e-1)" "unprognostic (9.11e-2)" "unprognostic (1.23e-1)" 7.9 6.2 6.1 14.6 6.0 10.1 11.1 6.0 7.3 10.6 7.6 17.2 15.7 16.5 12.0 12.9 16.3 14.9 8.9 5.9 6.1 44.5 7.1 11.5 14.5 4.9 5.6 16.0 11.4 7.8 4.6 11.5 5.6 8.3 17.9 14.9 6.8 10.1 7.7 11.6 14.4 15.3 5.1 11.4 15.4 19.6 5.5 15.7 15.0 12.5 15.2 12.7 7.5 7.4 32.2 28.6 43.6 29.8 13.2 22.5 30.9 42.7 23.9 43.7 37.0 37.8 40.8 45.7 30.9 20.5 25.3 41.2 36.3 28.0 54.6 34.5 23.3 29.1 44.3 12.8 9.5 56.4 25.3 10.0 17.3 51.1 27.3 13.8 17.1 39.8 26.7 35.5 25.6 25.3 63.4 25.3 26.4 95.3 29.1 60.0 109.4 37.9 20.2 30.6 29.0 19.5 50.7 25.3 49.7 26.2 29.5 35.7 16.4 42.9 30.8 48.8 34.2 24.8 56.6 102.4 24.5 35.1 33.2 7.3 22.6 15.9 9.2 18.5 9.1 10.1 11.7 8.2 17.7 8.0 11.6 9.6 19.4 10.8 19.0 5.2 13.7 13.0 6.1 6.0 6.0 7.3 5.9 6.1 4.9 5.6 5.6 5.1 5.5 7.4 14.8 12.8 20.0 13.1 9.7 5.9 7.0 11.4 12.5 12.3 10.5 12.8 7.8 7.2 17.7 9.2 8.4 19.7 11.1 17.9 5.9 17.2 28.3 24.8 17.1 14.2 5.4 24.2 20.1 32.1 26.7 13.1 16.8 14.4 19.0 20.9 8.2 4.9 15.6 23.5 15.3 12.7 12.2 12.9 7.2 23.1 12.5 16.9 3.6 15.0 25.3 15.3 9.2 6.6 18.7 17.4 13.4 8.6 11.4 11.4 10.7 39.1 45.2 19.1 6.6 13.7 12.4 60.3 37.7 11.2 5.4 13.0 11.8 10.0 19.9 10.5 POLD4 "p12, POLDS" ENSG00000175482 "DNA polymerase delta 4, accessory subunit" Q9HCU8 11 67350772-67356972 "Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA excision, DNA repair, DNA replication" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 272.0" "Cell type enhanced" "Detected in all" "Distal enterocytes: 538.2;Paneth cells: 572.5;Proximal enterocytes: 403.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "EFO-21: 177.0" "Low region specificity" "Detected in all" HPA078008 Approved "Centriolar satellite" NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 18: Non-specific - Mitochondria" "Cluster 38: EFO-21 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "Centriolar satellite" "HPA078008: " "unprognostic (7.55e-3)" "unprognostic (2.71e-1)" "unprognostic (3.93e-2)" "unprognostic (2.75e-1)" "unprognostic (1.19e-2)" "unprognostic (1.03e-1)" "unprognostic (8.25e-2)" "unprognostic (1.43e-2)" "unprognostic (4.82e-1)" "unprognostic (2.02e-1)" "unprognostic (3.19e-2)" "unprognostic (2.53e-1)" "unprognostic (2.39e-3)" "unprognostic (1.70e-1)" "unprognostic (4.11e-2)" "unprognostic (1.95e-1)" "unprognostic (9.36e-2)" 80.6 78.1 9.5 60.4 9.8 37.1 66.5 8.3 19.6 60.6 9.7 110.1 86.0 53.1 5.6 118.3 47.3 19.1 98.4 8.9 8.5 106.9 272.0 73.5 83.1 12.0 11.1 48.3 104.8 4.0 39.7 17.2 11.2 87.1 14.7 3.0 72.7 9.5 91.7 56.2 118.8 9.8 8.9 111.5 81.7 27.9 11.4 8.7 49.3 9.3 25.3 82.1 75.4 10.0 48.0 125.5 2.0 13.6 14.4 27.8 7.6 58.3 12.1 8.5 6.0 21.9 147.7 126.4 177.0 16.9 31.1 64.2 0.4 39.5 1.1 53.4 7.2 29.1 29.6 29.2 31.9 10.3 142.1 31.4 19.7 15.4 13.1 42.6 25.4 19.5 27.1 42.2 14.3 79.4 13.2 22.7 10.1 94.7 83.7 21.6 23.4 34.7 19.9 33.1 1.0 13.2 29.7 21.9 95.8 6.9 51.8 37.5 82.5 28.7 20.2 75.2 19.8 52.9 19.1 72.4 95.8 24.3 34.3 129.3 147.8 258.6 63.2 192.4 59.1 333.3 72.5 65.6 143.8 354.7 78.9 71.0 143.4 50.7 376.9 101.1 115.6 128.9 9.5 9.8 8.3 19.6 8.9 8.5 12.0 11.1 11.2 8.9 11.4 10.0 8.0 19.2 44.9 12.4 115.3 43.3 3.1 152.6 47.8 2.6 14.8 8.6 2.3 12.8 86.1 7.3 6.2 8.6 15.5 538.2 15.6 144.7 7.8 4.8 7.8 19.1 83.1 26.1 6.5 188.5 10.5 25.3 180.4 11.9 68.5 5.6 22.1 40.7 31.3 3.3 4.9 226.0 105.8 31.3 92.5 18.7 6.8 66.9 60.5 34.7 114.1 4.2 36.0 5.5 12.6 220.3 572.5 3.8 66.8 4.5 403.3 30.2 18.7 4.2 6.6 5.8 26.8 4.7 3.0 96.4 68.9 12.4 49.4 2.2 130.8 4.5 POLE POLE1 ENSG00000177084 "DNA polymerase epsilon, catalytic subunit" Q07864 12 132623753-132687376 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication" "DNA-binding, DNA-directed DNA polymerase, Hydrolase, Nucleotidyltransferase, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Spermatocytes: 46.6" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in some" 4 "cerebellum: 4.1;cerebral cortex: 1.1;hippocampal formation: 1.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in single" "Not detected" "Not detected" "HPA058210, HPA067385" Supported "Nucleoplasm,Plasma membrane" NA NA "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 24: NB-4 - Immune response" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "Plasma membrane" "HPA058210: AB_2683639, HPA067385: AB_2685830" "unprognostic (1.60e-1)" "unprognostic (1.77e-3)" "unprognostic (2.00e-1)" "unprognostic (9.17e-2)" "unprognostic (1.68e-1)" "unprognostic (2.01e-2)" "unprognostic (3.96e-3)" "unprognostic (2.23e-1)" "prognostic unfavorable (1.44e-4)" "unprognostic (7.12e-2)" "unprognostic (2.21e-1)" "unprognostic (1.67e-1)" "prognostic unfavorable (3.19e-8)" "unprognostic (8.60e-2)" "unprognostic (3.18e-1)" "unprognostic (1.28e-1)" "unprognostic (9.95e-2)" 6.0 2.9 0.2 6.1 0.2 24.7 6.0 4.1 1.1 6.4 0.3 7.3 6.5 5.4 2.1 7.0 6.2 3.1 4.3 1.6 0.0 3.0 8.6 5.0 7.2 0.3 0.1 7.8 6.5 2.6 2.7 5.3 0.3 6.4 6.3 2.4 6.1 3.3 7.5 13.2 8.5 3.7 0.1 16.2 8.0 16.2 0.5 15.7 4.7 3.0 7.1 6.1 6.2 0.3 25.3 33.3 48.7 22.0 10.2 7.6 39.9 26.0 11.7 30.3 21.8 38.3 14.5 28.7 10.2 14.1 11.6 33.6 35.4 16.7 18.8 13.3 41.2 45.4 45.7 15.2 1.9 37.2 24.9 5.5 6.0 31.8 10.5 8.1 10.8 35.1 53.4 15.7 14.9 33.3 61.8 46.8 36.9 9.3 18.5 48.0 27.6 13.0 6.9 40.8 40.6 22.0 30.0 22.7 4.7 23.4 35.0 19.1 9.9 26.5 24.7 20.6 25.9 20.3 14.5 44.8 14.7 26.3 19.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.0 0.2 0.2 4.1 1.1 1.6 0.0 0.3 0.1 0.3 0.1 0.5 0.3 3.2 0.0 6.7 7.5 4.0 5.7 3.8 3.0 4.0 8.7 7.8 6.7 6.9 1.5 1.6 1.8 0.0 8.8 5.6 18.8 0.0 2.3 8.2 3.2 3.8 4.9 7.2 14.9 13.6 3.3 10.8 5.1 11.2 6.8 2.5 16.2 8.9 10.5 13.2 0.0 7.6 9.1 2.0 6.9 5.4 9.7 6.8 2.9 5.4 4.7 1.6 2.6 2.1 3.5 2.9 2.6 6.0 3.4 6.3 4.0 4.1 1.0 1.9 6.1 26.3 7.0 6.1 46.6 18.2 5.8 7.7 4.0 5.8 2.9 10.9 2.8 POLE2 DPE2 ENSG00000100479 "DNA polymerase epsilon 2, accessory subunit" P56282 14 49643555-49688422 "FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "DNA replication" DNA-binding "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 18.2" "Cell type enhanced" "Detected in many" "Erythroid cells: 21.0;Spermatogonia: 24.4" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in some" HPA027555 Uncertain Supported "Nucleoplasm,Nuclear bodies,Vesicles" No No "Cluster 48: NK-cells - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Nuclear bodies" Vesicles "HPA027555: AB_10610282" "unprognostic (1.42e-1)" "unprognostic (6.57e-3)" "unprognostic (3.53e-2)" "unprognostic (7.44e-2)" "unprognostic (2.04e-2)" "unprognostic (4.99e-3)" "unprognostic (7.60e-3)" "unprognostic (2.32e-3)" "unprognostic (1.10e-3)" "unprognostic (2.69e-2)" "unprognostic (1.88e-2)" "unprognostic (1.37e-3)" "unprognostic (5.13e-11)" "unprognostic (9.97e-2)" "unprognostic (1.66e-1)" "unprognostic (1.27e-1)" "unprognostic (1.50e-3)" 0.9 0.9 0.5 5.1 0.3 18.2 3.0 0.5 0.6 2.1 0.0 3.8 2.5 2.5 0.7 3.7 1.0 0.9 0.6 0.2 0.2 0.7 3.1 1.2 5.1 0.2 0.4 1.0 0.8 0.7 0.5 3.0 0.2 1.4 4.5 3.0 1.0 0.7 0.5 3.5 3.6 2.3 0.3 1.5 2.1 4.1 0.2 5.5 0.9 0.9 6.2 1.4 1.9 0.6 37.2 18.6 34.3 16.3 1.7 9.9 18.2 20.4 10.4 31.9 36.7 19.3 27.5 23.6 11.6 11.6 17.5 22.3 35.3 12.8 36.9 27.4 19.6 35.4 20.6 23.9 0.8 41.2 14.6 2.8 0.8 18.5 2.9 4.1 19.0 30.5 30.9 14.3 31.6 32.7 43.6 28.4 20.2 30.9 42.6 35.9 31.7 21.0 11.6 20.6 24.8 14.3 20.5 11.9 6.7 16.5 24.5 15.8 6.7 5.3 38.5 21.4 16.9 10.7 22.7 52.7 9.8 30.1 20.9 0.0 0.0 0.2 0.2 0.0 0.1 0.3 0.2 0.4 0.1 0.2 0.0 0.2 0.0 0.9 0.0 0.2 0.7 0.1 0.5 0.3 0.5 0.6 0.2 0.2 0.2 0.4 0.2 0.3 0.2 0.6 2.0 3.2 0.5 4.2 2.4 4.8 2.1 1.9 2.2 0.8 1.5 1.1 1.2 1.5 1.3 0.0 0.0 9.1 1.0 2.2 0.0 1.3 1.2 0.8 2.6 1.5 1.2 21.0 9.5 1.5 10.6 2.7 1.1 1.5 0.0 4.3 5.0 5.5 5.5 0.0 11.9 2.8 0.0 1.9 1.6 0.8 1.5 1.1 1.8 7.5 1.0 2.0 4.1 12.1 11.5 0.8 0.5 3.0 5.7 1.9 1.1 1.2 0.9 3.1 0.0 2.1 7.4 5.3 24.4 6.0 3.7 3.4 1.7 1.8 4.7 1.5 POLE3 "CHARAC17, CHRAC17, CHRAC2, p17, Ybl1" ENSG00000148229 "DNA polymerase epsilon 3, accessory subunit" Q9NRF9 9 113407235-113410675 "FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" DNA-binding "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA047945 Uncertain Approved Nucleoplasm,Nucleoli NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Nucleoli" "HPA047945: AB_2680218" "unprognostic (9.55e-2)" "unprognostic (3.39e-3)" "unprognostic (1.56e-1)" "unprognostic (1.67e-1)" "unprognostic (6.52e-2)" "unprognostic (1.86e-2)" "prognostic unfavorable (8.35e-4)" "unprognostic (1.04e-2)" "unprognostic (1.60e-2)" "unprognostic (1.10e-1)" "unprognostic (4.59e-3)" "unprognostic (2.31e-3)" "unprognostic (1.75e-2)" "unprognostic (1.56e-2)" "unprognostic (1.04e-1)" "unprognostic (1.28e-1)" "unprognostic (1.18e-1)" 25.4 32.9 20.3 34.9 20.9 113.5 31.7 24.7 24.2 25.8 17.3 29.6 25.4 25.2 26.0 39.7 28.2 18.0 26.4 21.2 19.7 23.6 38.1 23.7 53.6 21.9 19.6 22.6 27.4 26.7 11.2 26.6 21.5 23.0 32.8 16.4 27.2 22.8 79.1 37.3 26.3 27.8 20.8 33.0 24.9 41.1 19.8 55.1 21.8 56.4 56.7 28.5 24.8 21.5 85.0 103.3 71.2 107.6 39.8 35.3 62.5 110.3 56.0 122.1 95.6 96.5 75.0 305.5 66.9 65.0 74.5 141.4 140.3 121.4 112.0 58.8 84.7 158.9 97.7 99.5 42.4 333.5 92.2 40.5 82.2 106.3 135.5 44.3 86.0 152.7 225.7 165.6 85.9 215.1 230.6 178.4 92.1 180.7 184.8 232.4 296.3 171.8 53.4 79.8 153.8 88.7 160.2 100.0 89.4 43.0 149.7 148.1 71.3 90.0 122.3 115.2 191.2 86.0 301.5 407.4 82.2 193.5 110.1 77.4 85.4 90.4 83.8 87.0 104.2 86.3 78.9 79.8 83.3 82.4 84.8 79.3 17.5 77.4 71.6 83.6 102.0 135.2 20.3 20.9 24.7 24.2 21.2 19.7 21.9 19.6 21.5 20.8 19.8 21.5 37.2 38.5 30.2 2.0 61.4 93.8 30.8 37.0 66.0 15.0 51.9 49.9 43.6 21.5 35.8 31.3 6.2 60.7 73.9 28.9 43.0 35.7 5.1 45.4 53.7 33.9 24.6 101.6 4.7 45.4 62.5 37.6 22.4 44.1 57.5 41.4 25.7 43.1 49.3 13.5 3.9 36.9 28.5 36.5 66.4 16.4 35.8 44.7 40.9 1.9 60.3 29.9 48.4 3.5 3.6 37.6 13.9 42.5 67.8 36.0 18.3 34.4 35.5 18.3 13.1 47.9 45.7 40.2 93.1 87.6 94.9 34.9 65.5 36.3 42.5 22.6 POLE4 p12 ENSG00000115350 "DNA polymerase epsilon 4, accessory subunit" Q9NR33 2 74958643-74970128 "FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" DNA-binding "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "NB-4: 110.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA054979, HPA071815" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 47: Non-specific - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm Cytosol "HPA054979: AB_2682661, HPA071815: AB_2686453" "unprognostic (2.56e-2)" "unprognostic (4.27e-2)" "unprognostic (1.17e-1)" "unprognostic (4.19e-2)" "unprognostic (4.85e-2)" "unprognostic (1.59e-2)" "prognostic unfavorable (6.49e-4)" "unprognostic (3.09e-1)" "unprognostic (1.99e-1)" "unprognostic (2.95e-1)" "unprognostic (1.39e-2)" "unprognostic (4.44e-2)" "unprognostic (8.64e-3)" "unprognostic (6.61e-2)" "unprognostic (3.73e-1)" "unprognostic (3.47e-2)" "unprognostic (1.95e-1)" 19.7 17.1 16.0 5.4 16.1 23.3 19.9 14.5 25.3 14.7 13.9 16.4 5.9 12.0 2.7 11.4 11.9 7.7 15.0 15.8 14.9 14.5 15.2 12.1 12.5 15.4 15.2 13.6 8.6 3.0 3.1 6.5 15.8 10.7 6.0 7.1 12.2 6.7 29.0 10.5 13.2 7.3 15.1 12.1 14.6 6.8 15.5 5.3 10.3 16.9 7.3 15.0 12.0 17.2 37.4 33.5 3.3 3.3 11.2 23.4 0.0 24.3 29.1 36.6 30.7 43.1 16.2 33.3 19.9 26.6 10.1 16.0 15.6 19.5 39.6 15.5 42.2 28.0 20.3 46.7 38.8 40.4 41.5 23.8 37.0 15.3 33.3 12.6 16.1 4.8 33.9 21.2 28.1 35.6 12.0 110.1 24.2 23.0 59.1 14.1 28.8 29.4 30.3 1.0 10.8 15.9 33.5 13.9 19.1 1.9 10.4 13.6 18.4 8.7 9.6 6.0 24.7 7.3 5.0 12.8 31.2 58.8 43.4 7.0 53.6 19.1 13.3 32.7 14.5 35.2 19.2 16.1 29.7 33.3 20.5 14.7 3.5 10.6 30.2 33.8 20.4 31.8 16.0 16.1 14.5 25.3 15.8 14.9 15.4 15.2 15.8 15.1 15.5 17.2 156.9 25.6 40.4 3.9 83.9 84.5 96.6 82.4 62.0 33.9 89.9 80.4 40.3 48.6 52.6 73.5 43.8 156.3 69.5 116.4 148.7 53.6 12.1 37.3 34.2 96.0 12.2 50.9 6.2 80.7 154.7 66.4 30.5 33.4 61.6 53.9 94.2 147.1 115.6 18.5 6.6 100.8 44.7 113.7 111.5 24.0 67.1 91.9 97.8 9.4 134.1 174.9 87.6 4.0 11.1 83.5 157.5 54.5 55.8 100.3 190.7 182.3 49.2 126.8 78.9 99.4 68.8 45.9 91.5 57.8 97.7 94.0 70.3 108.1 88.3 95.4 POLG "POLG1, POLGA" ENSG00000140521 "DNA polymerase gamma, catalytic subunit" P54098 15 89305198-89334861 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA replication" "DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase" "Disease variant, Epilepsy, Leigh syndrome, Neurodegeneration, Neuropathy, Primary mitochondrial disease, Progressive external ophthalmoplegia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA056821, HPA078482" Approved Supported Mitochondria NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 72: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 65: Plasmacytoid DCs - Unknown function" Mitochondria "HPA056821: AB_2683247, HPA078482: " "unprognostic (1.87e-1)" "unprognostic (4.71e-2)" "unprognostic (2.61e-2)" "unprognostic (3.64e-1)" "unprognostic (1.62e-1)" "unprognostic (3.19e-1)" "unprognostic (2.22e-1)" "unprognostic (1.13e-1)" "unprognostic (8.41e-2)" "unprognostic (2.63e-1)" "unprognostic (1.41e-1)" "prognostic unfavorable (5.73e-4)" "unprognostic (2.65e-3)" "unprognostic (1.58e-2)" "unprognostic (4.29e-2)" "unprognostic (2.07e-1)" "unprognostic (3.45e-1)" 13.3 11.1 6.8 4.0 5.0 2.6 12.0 4.8 6.3 12.0 4.5 13.3 5.5 12.9 0.4 14.6 11.2 0.9 13.8 6.1 3.5 10.1 12.9 13.8 3.0 9.0 5.8 10.8 10.7 2.9 8.4 2.5 6.5 10.5 0.9 1.4 12.3 2.2 25.0 16.0 14.5 1.3 5.4 16.2 11.9 5.4 5.7 7.3 10.5 10.9 2.4 12.2 12.7 6.3 8.0 17.0 6.7 10.0 7.7 1.6 16.4 16.4 2.7 7.9 5.9 28.0 10.9 14.4 33.6 5.9 16.9 11.8 14.3 4.8 0.9 35.8 31.3 19.4 19.5 11.1 10.8 21.3 33.6 2.4 8.7 7.0 3.0 8.3 12.2 26.8 19.5 5.4 6.1 22.8 16.3 16.5 8.7 13.7 8.2 18.2 13.7 17.4 3.2 19.2 24.5 6.9 26.8 9.6 16.8 6.0 7.7 10.8 17.3 12.8 15.6 28.5 14.2 17.0 9.4 18.6 9.5 14.3 11.6 3.3 4.3 6.1 5.5 4.0 4.3 2.0 4.6 6.8 6.0 3.0 3.7 4.4 1.8 5.0 3.5 4.1 3.3 5.3 6.8 5.0 4.8 6.3 6.1 3.5 9.0 5.8 6.5 5.4 5.7 6.3 15.7 12.8 11.9 11.4 17.2 12.2 11.0 10.7 9.1 7.6 12.0 10.3 19.0 11.5 9.5 11.0 2.1 15.0 33.8 17.2 9.8 10.4 1.3 8.4 9.4 12.4 5.4 9.0 12.9 10.9 15.8 11.9 21.4 11.3 8.2 14.8 14.6 17.8 12.7 3.3 9.9 24.9 4.1 18.5 14.7 1.5 14.3 17.2 19.6 8.4 21.8 6.1 30.9 9.5 11.9 11.4 15.9 10.5 16.8 17.7 10.5 7.5 7.8 6.4 6.6 13.3 12.9 9.2 11.1 11.8 11.9 21.8 21.7 14.8 17.6 15.5 POLG2 "HP55, MTPOLB" ENSG00000256525 "DNA polymerase gamma 2, accessory subunit" Q9UHN1 17 64477785-64497054 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "DNA replication" DNA-binding "Disease variant, Primary mitochondrial disease, Progressive external ophthalmoplegia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Skeletal myocytes: 92.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected" "Not detected" "CAB017030, HPA023202, HPA078396" Approved Supported "Nuclear bodies,Mitochondria" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 71: Testis - DNA repair" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 7: Non-specific - Mitochondria" Mitochondria "Nuclear bodies" "CAB017030: , HPA023202: AB_1855523, HPA078396: " "unprognostic (1.76e-1)" "unprognostic (2.20e-1)" "unprognostic (1.59e-1)" "unprognostic (7.02e-2)" "unprognostic (6.01e-2)" "unprognostic (2.91e-2)" "prognostic unfavorable (1.39e-6)" "unprognostic (4.38e-2)" "unprognostic (8.46e-2)" "unprognostic (3.14e-1)" "unprognostic (5.17e-3)" "prognostic unfavorable (6.59e-4)" "prognostic unfavorable (1.17e-5)" "unprognostic (5.17e-2)" "unprognostic (1.58e-1)" "unprognostic (2.88e-2)" "unprognostic (4.82e-2)" 4.5 5.8 2.7 4.4 3.0 3.6 4.5 3.9 4.5 6.8 3.0 4.7 3.5 4.7 2.0 4.0 5.6 2.4 5.0 2.8 3.6 5.7 5.3 3.9 5.4 3.2 3.0 7.9 4.7 2.4 4.0 2.9 3.1 5.1 1.9 2.6 3.9 2.9 6.8 4.2 5.6 2.0 2.9 7.5 4.0 12.8 3.1 6.3 5.8 4.2 4.0 4.8 5.3 3.9 8.1 10.4 6.7 7.6 7.2 4.7 8.4 4.6 4.6 7.0 5.9 10.1 6.2 15.7 5.4 2.8 6.5 5.3 9.3 3.9 8.8 4.6 11.0 9.9 12.2 10.5 7.0 14.2 10.6 4.5 4.7 5.3 7.2 8.4 4.7 7.6 18.3 4.7 6.5 10.0 15.3 15.4 7.3 8.6 11.2 13.3 23.8 14.2 6.4 2.4 9.3 10.0 4.4 7.1 8.0 8.7 7.4 12.0 6.1 7.0 9.9 5.8 12.3 8.4 7.2 11.3 5.9 13.4 4.8 7.2 5.2 6.0 6.5 3.2 6.6 10.7 7.5 6.2 9.7 11.9 9.7 9.7 0.9 5.8 8.4 4.4 8.1 4.0 2.7 3.0 3.9 4.5 2.8 3.6 3.2 3.0 3.1 2.9 3.1 3.9 24.6 12.8 21.2 7.8 19.6 8.2 13.7 7.8 16.5 5.0 30.1 37.5 18.4 12.8 13.3 3.7 0.0 13.0 22.7 31.7 0.0 5.4 14.7 16.5 26.7 16.0 10.9 20.4 9.1 3.8 14.4 19.2 14.8 29.2 13.3 9.9 14.6 4.7 9.2 6.7 7.4 13.9 6.1 6.9 7.1 7.3 6.5 17.7 7.2 11.2 8.0 4.5 18.6 13.0 14.1 2.9 21.8 3.0 6.3 9.8 8.9 5.2 7.1 9.2 6.6 92.0 18.4 49.7 9.2 10.8 8.7 4.0 16.2 15.2 19.8 5.2 POLH "RAD30A, XP-V" ENSG00000170734 "DNA polymerase eta" Q9Y253 6 43576185-43620523 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication, DNA synthesis" "DNA-binding, DNA-directed DNA polymerase, Mutator protein, Nucleotidyltransferase, Transferase" "Disease variant, Xeroderma pigmentosum" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Spermatocytes: 25.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 91.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006721, HPA026762" Approved Enhanced Nucleoplasm NA Yes "Cluster 15: NK-cells - Transcription" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 57: B-cells - Immune response" Nucleoplasm "HPA006721: AB_1847785, HPA026762: AB_10601248" "unprognostic (1.79e-1)" "unprognostic (7.29e-2)" "unprognostic (2.25e-1)" "unprognostic (7.28e-2)" "unprognostic (3.61e-1)" "unprognostic (5.11e-3)" "unprognostic (9.68e-2)" "unprognostic (1.40e-1)" "unprognostic (3.18e-1)" "unprognostic (7.75e-2)" "unprognostic (4.11e-3)" "unprognostic (2.24e-1)" "unprognostic (9.50e-2)" "unprognostic (6.73e-2)" "unprognostic (8.77e-2)" "unprognostic (7.91e-2)" "unprognostic (6.02e-2)" 5.0 3.8 2.3 6.9 2.7 4.2 4.8 5.1 2.9 5.9 5.3 7.0 4.6 4.2 3.6 5.5 5.5 4.3 3.7 2.2 2.2 4.7 5.6 5.7 12.9 2.7 2.2 4.7 5.4 3.7 3.2 4.0 2.7 4.7 7.2 7.4 4.0 3.8 8.5 8.5 4.4 6.3 1.8 5.6 4.6 10.6 2.5 12.9 6.8 4.7 14.2 4.8 4.3 3.6 46.7 9.7 13.5 19.9 17.6 29.1 33.0 48.6 13.9 26.2 29.2 12.0 7.9 48.9 12.0 17.6 7.6 11.4 13.1 28.6 31.5 25.9 10.0 15.3 31.6 35.5 13.4 26.8 19.2 19.5 33.4 21.5 11.3 10.6 24.3 14.5 24.0 29.6 33.0 15.0 23.9 6.4 4.2 33.2 7.2 25.1 14.3 11.8 9.9 34.6 15.1 5.4 14.5 12.9 7.3 15.4 17.9 10.8 36.2 23.6 24.4 12.2 25.2 28.0 21.3 91.1 11.8 14.5 27.3 4.1 1.7 2.7 4.2 1.6 3.8 5.0 3.5 3.1 1.3 4.9 2.8 3.0 1.7 4.2 1.6 2.6 4.6 2.0 2.3 2.7 5.1 2.9 2.2 2.2 2.7 2.2 2.7 1.8 2.5 3.6 3.1 12.8 8.2 12.1 15.1 4.7 3.2 4.8 19.4 6.3 3.4 3.3 2.3 5.7 6.5 3.7 10.4 2.4 5.2 6.3 5.9 2.1 11.4 10.2 4.8 2.8 5.4 5.7 14.8 0.9 2.8 5.3 8.2 9.0 0.0 6.1 1.4 2.4 1.7 0.0 15.3 2.2 4.1 2.2 2.2 7.3 3.4 3.0 1.8 6.5 3.2 2.6 2.1 10.1 13.4 1.9 4.5 3.0 12.7 2.2 3.1 2.3 5.4 9.4 0.0 7.0 5.0 25.9 6.7 13.0 3.0 1.9 8.8 5.6 3.0 2.3 POLI "RAD30B, RAD3OB" ENSG00000101751 "DNA polymerase iota" Q9UNA4 18 54269517-54321266 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication, DNA synthesis" "DNA-binding, DNA-directed DNA polymerase, Mutator protein, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 117.4;Spermatocytes: 80.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012000, HPA064696" Enhanced Supported "Nuclear speckles,Cytoplasmic bodies" NA NA "Cluster 24: B-cells - Unknown function" "Cluster 1: Thyroid gland - Transcription" "Cluster 12: NES - Nervous system development" "Cluster 66: Spermatocytes - Spermatogenesis" "Nuclear speckles" "Cytoplasmic bodies" "HPA012000: AB_1847786, HPA064696: AB_2685325" "unprognostic (1.64e-1)" "unprognostic (5.79e-3)" "unprognostic (9.72e-3)" "unprognostic (4.92e-2)" "unprognostic (3.04e-1)" "unprognostic (4.46e-2)" "unprognostic (1.31e-1)" "unprognostic (1.05e-2)" "unprognostic (4.04e-3)" "unprognostic (2.22e-2)" "unprognostic (2.07e-3)" "unprognostic (1.30e-3)" "unprognostic (1.55e-1)" "unprognostic (4.05e-2)" "unprognostic (1.26e-1)" "unprognostic (1.52e-2)" "unprognostic (6.99e-2)" 21.2 9.2 7.6 7.2 10.6 7.0 18.2 7.4 9.2 13.8 4.8 9.5 7.8 15.0 14.4 7.2 11.3 9.6 10.7 5.7 8.5 14.4 7.5 10.0 9.6 9.5 8.0 16.7 13.4 15.8 11.5 14.8 8.3 14.1 8.6 25.4 8.2 14.6 6.3 7.5 6.6 11.5 8.6 9.4 9.7 38.0 8.5 14.6 31.4 5.6 8.4 9.4 8.7 12.9 12.0 4.3 31.4 19.1 10.3 20.1 10.2 9.7 20.6 10.9 18.0 3.2 11.1 5.6 3.1 14.2 11.1 9.6 7.4 11.1 12.2 13.7 3.7 7.1 5.2 8.3 16.9 11.4 5.5 21.9 16.4 9.5 19.6 24.5 23.4 9.1 4.9 15.6 18.3 9.6 8.2 9.9 10.8 3.0 4.7 5.1 6.4 14.1 12.3 15.9 14.6 14.9 6.9 6.0 10.1 20.2 22.1 5.1 11.3 20.4 5.5 3.1 8.2 12.6 3.0 7.9 14.5 10.0 15.1 4.0 6.3 6.7 4.6 3.5 4.3 5.1 4.8 4.8 6.1 6.5 7.0 4.0 3.9 4.9 3.7 4.8 6.1 3.9 7.6 10.6 7.4 9.2 5.7 8.5 9.5 8.0 8.3 8.6 8.5 12.9 8.7 25.6 16.4 24.5 5.0 2.5 8.0 9.1 10.8 15.3 12.1 10.0 10.5 2.8 9.6 5.5 10.4 33.5 4.7 1.8 9.8 9.0 117.4 14.4 12.3 8.0 6.1 5.0 16.5 6.2 16.6 11.0 9.2 10.3 13.3 13.9 8.9 6.1 9.2 3.3 20.3 4.7 8.2 5.9 2.5 25.4 19.9 6.2 7.2 26.2 8.2 18.7 7.2 28.6 43.5 6.2 2.6 18.0 3.3 4.7 3.7 15.6 20.6 23.6 32.9 13.9 9.6 80.1 31.4 4.9 2.6 27.9 6.4 11.7 4.3 3.1 POLK "DINB1, DINP, POLQ" ENSG00000122008 "DNA polymerase kappa" Q9UBT6 5 75511756-75601144 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication, DNA synthesis" "DNA-binding, DNA-directed DNA polymerase, Mutator protein, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 236.8;Oligodendrocytes: 159.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012035, HPA057303, HPA068117, HPA069375" Enhanced Nucleoplasm NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 23: Spermatids - Flagellum & Golgi organization" Nucleoplasm "HPA012035: AB_2668606, HPA057303: AB_2683406, HPA068117: AB_2685957, HPA069375: AB_2686131" "unprognostic (9.66e-2)" "unprognostic (5.29e-2)" "unprognostic (5.37e-2)" "unprognostic (2.70e-1)" "unprognostic (1.86e-1)" "unprognostic (1.66e-1)" "unprognostic (1.73e-2)" "unprognostic (7.76e-2)" "unprognostic (1.65e-2)" "unprognostic (6.29e-3)" "unprognostic (2.42e-1)" "unprognostic (5.93e-2)" "unprognostic (1.80e-2)" "unprognostic (9.96e-3)" "unprognostic (1.58e-1)" "unprognostic (9.64e-2)" "unprognostic (2.02e-1)" 4.7 4.3 2.3 3.7 5.0 2.7 5.4 7.0 4.5 6.8 1.9 3.2 2.4 6.3 4.6 3.4 4.0 3.7 4.6 3.1 5.4 4.7 4.9 4.9 4.0 5.6 4.2 6.0 4.3 5.5 3.2 6.3 5.7 4.3 3.1 5.2 4.2 3.9 4.6 4.1 3.1 4.1 3.6 5.6 3.7 3.1 4.7 3.9 7.6 3.3 3.6 3.2 3.9 10.5 6.7 6.7 4.1 5.3 5.3 10.5 3.5 12.5 8.8 9.5 9.8 4.3 5.2 6.9 10.0 8.3 6.2 2.5 3.8 4.3 11.4 7.6 4.5 6.3 5.7 2.1 10.1 4.0 4.9 5.0 5.1 7.7 5.3 7.6 8.0 4.4 5.6 3.9 9.1 0.5 7.9 3.2 1.5 0.7 3.9 3.3 10.6 4.8 5.7 2.2 4.1 4.6 9.4 2.5 3.4 2.8 3.7 3.8 10.4 6.9 3.6 3.3 7.2 4.5 4.4 6.0 4.6 6.2 12.2 5.8 5.3 2.7 2.4 6.0 2.0 5.1 2.6 3.0 4.8 4.1 3.2 2.2 4.6 3.9 11.5 5.8 3.4 2.0 2.3 5.0 7.0 4.5 3.1 5.4 5.6 4.2 5.7 3.6 4.7 10.5 45.8 32.1 44.6 65.6 36.3 14.7 21.8 22.1 20.5 32.9 19.5 15.0 21.8 24.3 26.1 29.5 20.9 17.3 37.5 8.3 23.5 20.3 236.8 19.5 32.1 34.4 14.9 29.2 63.5 15.8 13.0 33.7 17.3 21.0 51.9 33.8 57.1 25.0 21.8 65.6 60.0 11.3 24.4 39.2 25.0 58.7 37.6 33.3 23.2 73.1 55.8 19.6 25.7 84.4 159.6 19.1 15.1 38.4 26.4 14.6 17.8 21.2 20.8 38.8 6.6 38.5 27.8 61.3 23.6 14.5 12.9 6.7 27.6 48.8 12.2 11.6 POLL ENSG00000166169 "DNA polymerase lambda" Q9UGP5 10 101578882-101588270 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication, DNA synthesis" "DNA-binding, DNA-directed DNA polymerase, Lyase, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA076828 Supported Nucleoplasm "Intracellular and membrane" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 22: Non-specific - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm "HPA076828: " "unprognostic (3.71e-3)" "unprognostic (6.93e-3)" "unprognostic (1.73e-2)" "unprognostic (2.47e-2)" "unprognostic (9.52e-2)" "unprognostic (1.80e-2)" "unprognostic (2.11e-2)" "unprognostic (1.24e-1)" "unprognostic (8.11e-2)" "unprognostic (1.71e-2)" "unprognostic (1.12e-2)" "unprognostic (7.19e-2)" "unprognostic (4.74e-2)" "unprognostic (1.06e-2)" "unprognostic (1.94e-1)" "unprognostic (3.86e-1)" "unprognostic (1.64e-3)" 17.4 22.4 17.3 12.4 18.0 12.8 19.6 15.9 19.0 21.1 18.2 21.8 16.8 19.4 22.6 18.1 22.1 15.6 19.9 17.5 16.0 24.8 26.9 15.6 17.0 16.3 16.3 26.3 45.6 21.3 28.5 13.7 17.2 26.0 17.1 17.4 20.8 15.4 34.4 16.1 18.7 14.2 14.1 22.7 27.6 41.4 17.1 7.4 26.1 18.2 17.1 20.9 17.7 17.4 23.5 21.0 16.2 23.0 16.2 30.0 22.7 15.3 26.4 22.9 23.9 15.5 27.8 5.7 23.5 13.9 12.6 28.8 18.4 22.6 18.4 20.8 24.8 18.1 23.1 17.7 29.8 19.0 16.2 27.5 30.3 25.0 51.8 64.1 24.7 11.1 20.4 19.2 14.7 18.8 0.0 20.8 8.6 13.0 12.4 0.1 14.6 9.9 19.2 14.1 11.2 16.6 9.4 15.7 26.5 23.8 47.3 11.0 13.5 8.1 16.4 9.8 16.8 28.4 15.3 8.9 17.5 16.6 6.3 0.6 9.2 1.3 6.5 6.6 10.6 8.4 7.4 6.8 11.6 6.8 11.7 8.0 1.0 9.5 6.7 0.2 10.2 7.6 17.3 18.0 15.9 19.0 17.5 16.0 16.3 16.3 17.2 14.1 17.1 17.4 7.5 6.4 12.9 13.7 11.4 3.7 6.7 9.7 7.4 16.9 14.7 19.0 8.6 11.5 7.4 7.3 47.9 16.9 7.5 9.1 5.9 9.6 25.2 7.3 7.5 7.6 13.1 25.9 10.4 21.5 9.8 9.6 20.9 6.6 14.0 20.9 8.6 10.9 11.2 21.9 7.9 13.6 18.3 17.7 6.0 51.6 14.0 9.6 10.6 2.8 18.0 10.1 13.4 8.5 9.9 13.7 9.2 11.3 10.9 6.5 13.7 11.6 7.2 24.0 13.1 10.8 9.6 35.5 11.0 8.4 2.0 11.5 9.4 14.4 15.6 5.6 POLM Tdt-N ENSG00000122678 "DNA polymerase mu" Q9NP87 7 44072062-44082530 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA recombination, DNA repair" "DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Rod photoreceptor cells: 48.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 63.0" "Lineage enriched" "Detected in all" 6 "granulocytes: 63.0" "Cell line enhanced" "Detected in all" "HBEC3-KT: 67.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA058900, HPA066007" Approved Nucleoplasm NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 72: Non-specific - Transcription" "Cluster 30: Epithelial cell lines - Translation" "Cluster 52: Non-specific - Transcription" Nucleoplasm "HPA058900: AB_2683848, HPA066007: AB_2685595" "unprognostic (2.44e-2)" "unprognostic (8.18e-2)" "unprognostic (2.21e-3)" "unprognostic (3.93e-2)" "unprognostic (5.40e-2)" "unprognostic (1.83e-1)" "unprognostic (2.75e-1)" "unprognostic (1.22e-1)" "unprognostic (5.12e-2)" "unprognostic (3.91e-1)" "unprognostic (9.36e-2)" "unprognostic (8.26e-2)" "unprognostic (2.46e-3)" "unprognostic (6.31e-2)" "unprognostic (1.47e-1)" "unprognostic (2.87e-1)" "unprognostic (3.87e-3)" 8.0 5.9 4.0 4.4 4.0 4.5 7.8 4.4 4.1 8.8 4.0 6.6 5.6 6.1 3.7 8.4 6.4 4.4 7.5 3.5 3.7 10.2 9.7 5.9 7.6 4.4 5.2 8.9 8.5 4.4 6.0 2.8 4.5 8.4 3.4 4.3 7.5 6.7 7.9 8.9 9.0 3.5 3.9 13.1 9.1 3.8 5.1 9.8 10.5 4.9 7.2 7.6 7.8 4.0 1.8 2.5 2.6 5.8 3.6 4.2 7.5 6.1 6.2 4.5 2.5 3.2 4.2 18.1 5.6 4.7 5.5 5.3 2.7 67.0 2.6 6.3 6.0 2.3 2.8 1.1 4.8 5.8 7.7 6.1 6.0 3.7 4.4 8.6 8.1 18.5 2.7 9.2 3.8 4.1 10.5 4.7 5.4 5.5 14.2 9.6 1.6 7.3 4.7 2.9 2.7 4.8 2.9 11.3 5.6 4.0 6.7 10.2 5.7 3.1 4.4 3.2 8.6 14.1 7.5 13.9 5.6 5.2 6.9 23.9 3.5 10.7 6.3 4.3 6.5 7.9 5.5 5.6 3.3 11.1 7.9 6.3 63.0 7.4 3.3 9.5 5.8 2.9 4.0 4.0 4.4 4.1 3.5 3.7 4.4 5.2 4.5 3.9 5.1 4.0 8.3 3.2 7.8 13.1 33.4 4.5 11.2 8.3 11.4 24.5 10.3 6.2 5.6 15.7 11.4 12.9 29.2 12.3 19.9 11.1 1.9 7.6 0.6 5.0 7.1 8.7 5.4 3.0 4.0 9.4 9.4 7.1 27.5 6.0 24.1 11.1 12.5 9.2 10.2 18.5 4.3 8.5 10.2 11.1 5.0 0.7 14.0 9.9 10.6 6.5 14.4 11.9 23.7 3.5 5.7 8.3 22.5 10.1 15.6 16.6 19.4 5.6 7.4 48.3 0.0 6.9 9.0 17.5 14.3 6.5 5.1 9.7 18.8 13.5 12.1 15.0 POLN ENSG00000130997 "DNA polymerase nu" Q7Z5Q5 4 2071918-2242121 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication" "DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "adipose tissue: 2.4;testis: 2.6" "Cell type enhanced" "Detected in many" "Astrocytes: 32.3;Excitatory neurons: 77.7;Inhibitory neurons: 42.7;Oligodendrocyte precursor cells: 22.1;Oligodendrocytes: 26.8;Spermatocytes: 23.4" "Low cancer specificity" "Detected in single" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "ASC diff: 1.7" "Not detected" "Not detected" "Not detected" "Not detected" "HPA035939, HPA035940" Enhanced Nucleoplasm NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 71: Testis - DNA repair" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "HPA035939: AB_2674875, HPA035940: AB_2674876" "unprognostic (8.52e-3)" "unprognostic (1.55e-1)" "unprognostic (4.87e-2)" "unprognostic (1.32e-1)" "unprognostic (2.53e-1)" "unprognostic (1.45e-2)" "unprognostic (3.46e-1)" "unprognostic (2.70e-1)" "unprognostic (5.83e-2)" "unprognostic (2.23e-1)" "unprognostic (2.02e-3)" "unprognostic (1.25e-1)" "unprognostic (1.49e-3)" "unprognostic (9.14e-2)" "unprognostic (2.67e-1)" "unprognostic (2.66e-1)" "unprognostic (1.82e-2)" 2.4 0.6 0.3 0.0 0.4 0.0 1.0 0.2 0.5 0.3 0.0 0.3 0.1 0.3 0.7 0.1 0.4 0.3 0.3 0.3 0.0 0.4 0.4 0.2 0.2 0.0 0.0 0.2 0.4 0.1 0.4 0.1 0.0 0.6 0.0 0.2 0.5 0.2 0.4 0.3 0.3 0.1 0.0 0.3 0.3 2.6 0.1 0.1 0.3 0.1 0.1 0.2 0.2 0.4 0.0 0.6 0.0 0.3 1.7 0.5 0.0 0.1 0.1 0.0 0.3 0.0 0.0 0.3 0.0 0.4 0.0 0.0 0.5 0.0 0.1 0.0 0.5 0.0 0.4 0.0 0.0 0.0 0.2 0.7 0.2 0.3 0.2 0.5 0.1 0.0 0.0 0.2 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.2 0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.4 2.4 0.0 0.0 32.3 1.0 0.9 1.0 0.6 0.6 4.2 3.0 1.5 3.6 1.5 1.7 0.0 0.0 0.2 0.6 0.2 3.9 0.4 8.3 4.2 2.0 1.9 4.8 0.8 77.7 1.0 0.3 2.0 1.5 2.1 0.0 5.5 3.3 1.1 0.7 3.3 42.7 0.0 2.0 1.3 1.0 14.1 4.4 1.3 0.0 15.0 0.7 2.5 1.0 22.1 26.8 0.5 1.1 3.8 1.5 1.0 0.3 0.8 1.9 3.8 0.0 2.9 1.1 23.4 10.4 0.5 1.6 0.0 1.8 4.1 0.3 1.3 POLQ POLH ENSG00000051341 "DNA polymerase theta" O75417 3 121431427-121546641 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair" "DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 6.0;lymphoid tissue: 4.5" "Cell type enhanced" "Detected in many" "Erythroid cells: 16.4;Excitatory neurons: 9.5;Granulosa cells: 12.6;Inhibitory neurons: 7.8;Plasma cells: 12.2" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in single" "cerebellum: 1.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Region enhanced" "Detected in single" "cerebellum: 2.5" HPA053359 Supported "Nucleoplasm,Golgi apparatus,Cytosol" NA Yes "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "Golgi apparatus, Cytosol" "HPA053359: " "unprognostic (1.59e-1)" "unprognostic (4.18e-2)" "unprognostic (2.66e-2)" "prognostic unfavorable (5.46e-5)" "unprognostic (2.70e-1)" "unprognostic (6.23e-3)" "unprognostic (3.09e-5)" "unprognostic (8.55e-3)" "unprognostic (1.09e-4)" "unprognostic (2.86e-1)" "unprognostic (5.59e-5)" "unprognostic (2.06e-3)" "unprognostic (0.00e+0)" "prognostic favorable (1.04e-4)" "unprognostic (1.76e-1)" "unprognostic (6.01e-2)" "unprognostic (5.76e-2)" 0.1 0.2 0.0 1.6 0.1 6.0 0.4 1.0 0.2 0.2 0.0 1.2 1.2 0.2 0.0 2.0 0.0 0.1 0.2 0.2 0.0 0.0 0.1 0.2 2.8 0.0 0.0 0.0 0.0 0.1 0.0 1.0 0.0 0.1 2.0 0.0 0.3 0.0 0.0 1.4 0.9 0.4 0.0 0.8 0.5 2.2 0.0 4.5 0.0 0.0 2.3 0.3 0.5 0.0 18.2 12.1 10.2 7.2 0.9 1.2 9.2 8.5 3.2 9.7 12.9 9.8 6.6 21.5 3.7 4.6 11.7 14.0 12.2 5.4 16.4 6.3 6.7 13.8 8.0 6.1 0.1 15.1 12.1 0.2 0.4 8.9 5.4 1.7 4.9 7.9 9.3 15.9 10.3 7.1 13.7 8.8 9.7 5.5 5.9 11.4 12.2 7.6 3.1 10.3 5.5 5.0 9.8 5.2 3.4 8.8 4.8 14.8 3.8 8.6 11.2 3.4 11.1 8.0 6.9 21.8 4.1 11.0 6.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 1.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.5 1.6 0.7 0.9 0.5 0.6 0.0 0.9 0.6 0.6 1.6 0.0 2.0 0.0 0.0 3.1 0.6 1.6 0.0 0.1 0.4 0.9 1.0 0.5 0.0 16.4 9.5 0.0 3.3 1.2 4.6 1.0 0.0 12.6 0.0 0.2 2.3 0.0 7.8 1.6 2.0 1.3 1.2 0.7 0.3 1.7 0.0 1.0 0.6 0.4 0.0 1.5 1.3 0.2 1.2 0.0 12.2 0.5 0.2 0.1 2.4 0.2 0.0 0.1 1.0 6.8 3.4 4.9 0.1 0.3 1.8 0.9 3.2 0.8 POLR1A "DKFZP586M0122, FLJ21915, RPA1, RPA190, RPO1-4" ENSG00000068654 "RNA polymerase I subunit A" O95602 2 86020216-86106155 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RNA polymerase related proteins" Transcription "Nucleotidyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010145, HPA031513, HPA049700" Supported Enhanced "Nucleoplasm,Nucleoli fibrillar center,Intermediate filaments" No No "Cluster 7: Monocytes - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" "Nucleoli fibrillar center" "Nucleoplasm, Intermediate filaments" "CAB010145: AB_675814, HPA031513: AB_2673916, HPA049700: AB_2680856" "unprognostic (1.22e-1)" "unprognostic (1.82e-2)" "unprognostic (1.55e-1)" "unprognostic (2.46e-2)" "unprognostic (1.32e-1)" "unprognostic (1.93e-1)" "prognostic unfavorable (3.70e-9)" "unprognostic (1.06e-2)" "unprognostic (1.35e-1)" "prognostic unfavorable (3.37e-4)" "unprognostic (4.31e-2)" "unprognostic (4.56e-2)" "unprognostic (3.27e-1)" "unprognostic (2.20e-3)" "unprognostic (1.94e-1)" "prognostic unfavorable (8.41e-4)" "unprognostic (7.20e-2)" 5.4 5.7 3.7 5.8 4.0 4.9 4.5 3.1 4.7 4.9 4.0 4.9 4.1 8.2 3.0 6.0 5.2 2.9 5.8 3.9 3.6 4.6 5.0 4.0 4.6 3.4 3.6 5.2 5.2 7.1 4.9 5.0 3.3 4.5 5.0 3.5 3.9 5.1 10.8 5.5 3.8 6.9 2.7 3.8 4.5 6.2 4.4 6.2 4.5 7.4 4.9 5.2 4.2 4.3 18.5 41.1 18.0 34.7 17.2 13.7 25.9 16.6 10.9 23.2 14.4 51.9 14.2 41.9 17.2 17.0 22.7 20.9 46.6 24.4 20.6 17.6 24.0 36.2 18.0 35.1 12.1 34.8 18.7 10.5 15.0 34.6 26.7 8.8 18.2 19.0 48.8 10.3 16.2 16.4 25.8 15.1 32.7 24.4 26.8 30.7 39.5 19.6 10.5 29.7 27.7 14.6 18.3 23.8 12.7 12.3 14.0 12.0 29.3 28.0 22.2 24.3 33.8 14.5 15.3 35.7 14.6 29.3 25.3 0.5 0.4 0.0 0.7 0.6 0.9 0.5 0.3 0.6 0.4 0.6 0.3 0.4 0.1 0.5 0.5 0.7 0.1 0.4 3.7 4.0 3.1 4.7 3.9 3.6 3.4 3.6 3.3 2.7 4.4 4.3 4.9 3.2 9.1 13.4 8.8 4.2 4.9 5.3 12.0 12.4 6.2 5.5 11.1 8.6 4.7 9.2 16.7 6.3 7.2 5.1 3.9 6.0 3.0 5.4 13.8 6.5 9.6 10.9 19.7 4.9 5.4 7.7 8.2 6.9 6.3 11.0 4.2 8.3 12.5 11.8 18.1 6.7 2.0 3.1 3.5 1.7 6.2 5.5 5.4 6.5 3.3 4.2 6.2 20.1 18.2 6.6 3.0 5.3 10.1 9.1 3.5 3.4 5.2 9.7 0.0 14.3 6.2 5.0 7.2 13.4 2.7 3.8 7.5 12.4 10.4 4.0 POLR1B "FLJ10816, FLJ21921, RPA135, RPA2, Rpo1-2" ENSG00000125630 "RNA polymerase I subunit B" Q9H9Y6 2 112541915-112579818 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RNA polymerase related proteins" Transcription "Nucleotidyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in many" 4 "Early spermatids: 181.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA037528 Supported "Nucleoli fibrillar center,Cytosol" NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 23: Spermatids - Flagellum & Golgi organization" "Nucleoli fibrillar center" Cytosol "HPA037528: AB_10671627" "unprognostic (1.66e-1)" "unprognostic (3.17e-2)" "unprognostic (2.55e-1)" "prognostic unfavorable (2.71e-5)" "unprognostic (2.07e-1)" "unprognostic (1.16e-2)" "unprognostic (1.98e-3)" "unprognostic (1.98e-1)" "unprognostic (2.05e-1)" "unprognostic (1.13e-1)" "prognostic unfavorable (5.52e-4)" "unprognostic (6.12e-2)" "unprognostic (1.29e-2)" "unprognostic (1.18e-1)" "unprognostic (2.19e-1)" "unprognostic (1.08e-1)" "unprognostic (3.56e-2)" 5.7 4.6 2.9 5.6 3.0 4.1 8.2 3.5 3.1 5.3 3.8 5.5 4.4 4.7 4.4 8.1 6.7 3.7 4.1 2.8 3.5 8.1 10.7 4.1 9.3 2.6 2.7 6.3 8.1 11.9 4.4 5.6 2.5 5.0 6.2 5.2 3.8 4.7 7.5 5.2 3.8 5.3 2.6 6.7 4.3 8.4 3.1 7.2 10.7 6.4 10.8 7.9 3.6 3.4 21.1 21.6 11.2 28.2 13.9 13.2 24.0 15.1 11.9 24.0 21.5 48.8 12.5 46.1 22.9 9.8 18.8 29.5 56.1 30.6 28.4 22.3 30.9 26.5 21.4 37.1 14.2 43.6 18.1 12.7 21.6 25.4 39.6 9.8 19.9 10.2 55.0 16.8 13.2 17.5 20.5 29.7 66.3 29.5 42.8 30.9 21.3 54.1 17.2 19.2 34.3 29.1 12.1 34.7 19.7 13.8 16.3 15.6 15.9 14.6 23.2 13.7 21.8 24.3 44.4 40.9 11.0 28.8 13.1 0.4 8.0 3.3 10.0 8.3 21.5 11.4 9.9 10.7 14.2 11.6 12.4 12.5 0.8 15.3 6.5 3.5 15.2 9.6 2.9 3.0 3.5 3.1 2.8 3.5 2.6 2.7 2.5 2.6 3.1 3.4 4.8 16.0 5.9 4.6 8.5 15.0 4.7 4.1 9.6 3.6 4.2 3.7 6.4 7.2 5.8 9.2 2.1 3.4 6.5 2.0 5.9 3.9 181.9 3.5 7.6 5.8 3.6 5.9 8.8 4.6 2.8 3.5 8.6 4.2 5.1 6.5 1.4 9.4 3.8 1.7 9.2 3.8 0.0 4.3 3.7 40.9 3.1 3.8 1.8 3.7 4.5 4.3 8.2 7.5 8.1 3.8 5.8 3.0 6.4 6.2 1.2 5.1 3.2 2.9 0.0 5.1 3.5 10.3 7.9 12.7 17.2 0.5 6.2 6.8 5.5 3.9 POLR1C "AC40, RPA39, RPA40, RPA5, RPAC1, RPC40" ENSG00000171453 "RNA polymerase I and III subunit C" O15160 6 43509702-43562419 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" Transcription "Disease variant, Leukodystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "OE19: 306.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031010 Supported "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 27: Brain & Skin - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Nucleoli fibrillar center" "HPA031010: AB_10603131" "unprognostic (2.84e-1)" "unprognostic (1.67e-1)" "unprognostic (3.15e-1)" "unprognostic (6.57e-2)" "unprognostic (7.01e-2)" "unprognostic (3.59e-1)" "unprognostic (6.69e-3)" "unprognostic (1.09e-3)" "unprognostic (2.00e-3)" "unprognostic (1.90e-2)" "unprognostic (2.05e-1)" "unprognostic (7.32e-2)" "prognostic unfavorable (4.17e-4)" "unprognostic (1.20e-2)" "unprognostic (4.69e-2)" "unprognostic (3.01e-1)" "unprognostic (6.41e-2)" 15.5 19.2 16.0 12.3 16.0 7.7 20.3 15.7 20.9 15.3 19.8 18.4 13.1 15.1 15.7 21.3 21.0 9.5 13.3 16.0 16.4 17.6 17.7 11.0 13.9 15.9 15.9 14.4 15.5 17.1 13.8 12.2 16.2 14.4 15.5 6.6 15.8 12.0 15.3 20.5 10.9 14.8 16.0 12.7 14.6 20.1 16.3 12.5 16.1 13.4 20.8 23.4 15.5 17.1 76.0 61.7 26.6 72.3 40.0 43.0 42.1 45.3 33.5 49.7 42.2 82.5 25.2 85.2 48.3 44.2 42.5 45.2 64.7 57.6 57.6 45.4 67.7 58.3 57.2 115.7 50.1 90.0 39.1 38.7 54.8 67.9 85.4 29.4 39.6 35.4 136.9 24.5 44.0 106.4 47.4 65.0 49.2 306.8 52.9 31.9 41.8 57.6 60.7 104.1 49.0 32.8 39.6 34.1 62.2 19.4 36.9 77.9 47.6 35.3 48.1 38.4 72.3 35.1 85.0 146.0 24.1 60.9 40.0 5.7 30.0 4.6 34.1 24.0 46.5 51.1 40.4 34.1 42.4 55.0 55.1 49.6 2.7 41.7 20.5 38.6 32.7 34.0 16.0 16.0 15.7 20.9 16.0 16.4 15.9 15.9 16.2 16.0 16.3 17.1 13.0 12.8 17.7 9.8 24.9 61.8 50.6 34.3 42.1 8.2 24.0 23.6 5.2 17.2 30.4 5.5 6.2 29.7 15.3 11.3 15.6 26.7 13.5 23.4 15.9 18.6 13.1 12.8 13.6 24.4 18.9 21.5 25.0 14.2 14.0 14.4 15.7 11.9 13.3 5.0 12.3 17.4 28.5 5.2 17.0 8.3 11.5 8.5 21.4 11.2 8.3 7.1 14.4 14.1 10.2 21.0 11.5 11.7 13.1 29.2 5.0 27.5 48.5 15.4 6.6 29.1 45.6 34.4 43.3 26.4 40.9 13.5 17.4 21.5 19.9 37.0 POLR1D "AC19, MGC9850, RPA16, RPA9, RPAC2, RPO1-3" ENSG00000186184 "RNA polymerase I and III subunit D" "P0DPB5, P0DPB6" 13 27620742-27744237 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" Transcription "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 819.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039337 Uncertain Approved "Nucleoplasm,Golgi apparatus" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 50: Non-specific - Ribosome" "Cluster 30: Epithelial cell lines - Translation" "Cluster 32: Non-specific - Translation" "Nucleoplasm, Golgi apparatus" "HPA039337: AB_10672961" "unprognostic (1.33e-3)" "unprognostic (5.96e-2)" "unprognostic (4.35e-2)" "unprognostic (8.50e-3)" "unprognostic (1.98e-2)" "unprognostic (3.71e-3)" "unprognostic (5.33e-3)" "unprognostic (2.04e-1)" "unprognostic (4.18e-2)" "unprognostic (4.39e-2)" "unprognostic (2.80e-1)" "unprognostic (5.18e-3)" "unprognostic (1.87e-1)" "unprognostic (1.29e-1)" "unprognostic (2.56e-2)" "unprognostic (8.28e-2)" "unprognostic (6.45e-2)" 72.1 124.8 56.0 57.4 58.5 150.8 90.6 77.5 75.5 102.5 67.2 98.7 86.2 67.5 78.1 142.3 75.7 55.8 90.7 58.4 57.3 84.4 81.2 76.5 90.8 53.4 54.7 118.7 267.3 54.2 69.3 62.3 54.9 88.6 87.4 58.5 112.5 65.7 119.9 143.4 86.6 66.4 52.7 75.6 132.9 76.0 55.3 117.5 62.2 85.0 87.3 91.7 111.7 56.3 103.2 94.8 106.8 110.5 121.6 213.4 143.4 99.2 171.2 129.2 127.7 155.0 203.9 331.3 73.2 113.9 215.7 155.4 200.4 319.8 152.3 102.5 119.0 236.0 97.4 262.9 181.4 215.7 178.0 195.5 330.2 106.0 194.6 143.9 180.9 187.9 132.3 56.6 126.8 106.7 213.2 257.7 259.1 320.2 100.4 144.0 182.6 151.1 204.7 157.2 182.2 142.3 67.3 132.0 381.4 133.9 81.3 198.6 124.9 56.5 90.1 97.9 110.3 92.2 113.1 188.4 49.5 152.3 112.9 80.0 115.9 56.3 71.0 124.4 94.5 83.9 114.9 91.8 130.9 83.8 121.8 98.4 42.0 88.8 113.5 95.9 179.0 83.8 56.0 58.5 77.5 75.5 58.4 57.3 53.4 54.7 54.9 52.7 55.3 56.3 122.5 89.8 108.8 13.7 147.4 336.6 303.0 247.7 385.3 56.6 171.4 241.4 73.5 118.7 123.8 29.5 16.7 155.0 133.9 104.5 74.3 137.2 464.1 100.9 98.4 111.8 124.4 182.4 30.0 309.2 273.2 100.5 126.4 106.3 95.7 125.8 112.5 81.2 165.7 45.4 22.2 203.5 65.1 205.2 148.2 819.5 116.5 142.5 80.0 19.7 260.9 56.5 151.4 13.6 22.3 232.1 124.6 79.0 105.9 256.2 210.1 152.1 58.5 44.0 78.9 105.2 164.4 268.0 81.9 307.8 317.0 145.8 148.5 179.8 197.2 345.7 POLR1E "FLJ13390, FLJ13970, PAF53, PRAF1, RPA49" ENSG00000137054 "RNA polymerase I subunit E" Q9GZS1 9 37485948-37503697 "Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, RNA polymerase related proteins" Transcription "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022527, HPA052400" Supported Supported "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 32: Non-specific - Translation" "Nucleoplasm, Nucleoli fibrillar center" "HPA022527: AB_1854924, HPA052400: AB_2681815" "prognostic favorable (2.27e-4)" "unprognostic (2.09e-1)" "unprognostic (9.90e-3)" "unprognostic (1.10e-2)" "unprognostic (7.16e-3)" "unprognostic (2.07e-1)" "unprognostic (1.09e-2)" "unprognostic (7.14e-2)" "unprognostic (1.04e-1)" "unprognostic (2.48e-1)" "unprognostic (2.80e-1)" "unprognostic (2.48e-1)" "unprognostic (1.07e-1)" "unprognostic (4.96e-2)" "unprognostic (5.23e-1)" "unprognostic (1.58e-1)" "unprognostic (4.24e-2)" 20.8 15.3 9.4 14.6 9.7 13.1 24.0 9.7 9.0 22.7 7.0 17.9 8.5 24.3 14.8 13.9 20.0 12.6 18.4 8.8 10.6 8.4 29.7 11.9 19.3 9.0 9.5 42.4 27.9 11.5 9.4 8.3 9.4 14.0 10.9 8.9 18.0 17.4 19.1 15.7 10.9 22.5 10.2 10.9 15.0 9.1 9.6 17.0 13.7 10.5 21.6 17.9 17.0 10.4 58.5 53.7 29.0 46.2 53.2 67.8 18.9 50.6 19.5 51.2 45.0 46.4 18.9 84.1 23.8 58.5 34.9 23.8 71.5 60.0 64.2 81.9 33.6 40.4 68.0 33.3 39.7 78.2 27.5 72.7 20.9 100.4 85.7 32.2 26.5 46.0 107.5 36.0 45.6 28.0 54.5 26.8 51.7 39.7 43.5 47.8 26.7 40.5 26.7 21.4 41.3 33.9 33.7 26.7 43.8 23.8 26.0 51.4 18.3 60.3 91.9 52.3 102.2 19.5 29.6 87.7 20.8 48.8 51.2 0.0 3.5 2.2 14.2 6.0 22.7 10.1 13.5 14.5 5.6 11.5 16.6 14.7 1.1 13.1 5.2 3.9 8.0 7.5 9.4 9.7 9.7 9.0 8.8 10.6 9.0 9.5 9.4 10.2 9.6 10.4 7.2 0.0 8.4 1.6 20.4 28.3 23.7 10.9 21.1 7.0 13.2 15.2 8.6 14.3 7.4 0.0 4.2 15.6 20.0 4.3 7.9 13.8 5.6 5.4 20.1 7.1 1.8 15.4 1.8 21.6 21.4 16.1 8.6 6.7 8.8 14.0 3.9 18.7 7.4 3.3 2.4 7.7 6.1 10.3 8.0 10.7 14.9 8.1 5.4 3.7 9.2 9.2 12.3 1.5 2.1 14.1 3.0 15.1 28.3 23.6 3.1 5.9 4.1 6.9 0.0 22.1 15.9 20.6 23.5 14.0 17.8 8.3 23.7 31.9 11.9 12.7 POLR1H "A12.2, HTEX-6, hZR14, RPA12, tctex-6, ZNRD1" ENSG00000066379 "RNA polymerase I subunit H" Q9P1U0 6 30058899-30064909 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" Transcription "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Adipocytes: 14.6;B-cells: 17.6;Cardiomyocytes: 15.2;Cytotrophoblasts: 28.2;dendritic cells: 20.5;Extravillous trophoblasts: 43.0;Hofbauer cells: 35.3;Syncytiotrophoblasts: 17.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA055074, HPA077979" Supported Supported "Nucleoli fibrillar center" NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 72: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 24: Non-specific - Transcription regulation" "Nucleoli fibrillar center" "HPA055074: AB_2682690, HPA077979: AB_2732366" "unprognostic (4.94e-2)" "unprognostic (2.93e-2)" "unprognostic (2.54e-1)" "unprognostic (3.81e-1)" "unprognostic (3.88e-2)" "unprognostic (8.55e-2)" "unprognostic (5.36e-2)" "unprognostic (2.82e-3)" "unprognostic (1.96e-1)" "unprognostic (9.52e-3)" "unprognostic (5.18e-1)" "unprognostic (3.28e-1)" "prognostic unfavorable (2.17e-7)" "unprognostic (2.57e-1)" "unprognostic (1.51e-1)" "unprognostic (9.97e-2)" "prognostic favorable (2.75e-5)" 26.0 26.2 5.0 4.3 5.0 2.6 22.4 4.7 9.6 24.4 5.1 22.4 16.8 22.7 4.7 29.3 21.7 1.1 23.7 5.2 6.2 32.3 24.4 19.7 2.9 5.5 5.6 25.4 30.0 2.4 18.0 5.8 5.4 21.1 14.2 4.3 16.8 2.7 25.4 23.0 24.7 4.0 5.4 33.2 26.3 30.5 5.3 13.1 17.5 7.7 3.3 23.0 22.1 5.2 17.9 5.4 20.5 40.9 5.7 5.9 6.9 7.2 19.4 19.9 18.7 23.0 9.3 16.2 7.3 8.1 10.4 10.8 37.4 27.7 25.4 2.0 43.1 24.6 13.7 31.0 36.4 33.8 8.1 22.5 13.1 20.4 49.0 6.4 32.3 25.1 60.8 8.3 15.5 29.9 22.9 67.5 0.0 29.9 28.1 18.1 26.5 30.2 11.5 23.7 12.5 20.0 10.0 19.5 10.4 9.8 19.1 30.4 7.3 19.5 8.0 0.0 23.1 9.7 10.7 20.4 3.4 33.1 25.4 22.1 5.3 4.4 6.5 3.9 6.7 4.9 6.0 6.1 6.3 4.3 6.6 5.1 4.0 5.1 3.9 4.9 7.8 4.0 5.0 5.0 4.7 9.6 5.2 6.2 5.5 5.6 5.4 5.4 5.3 5.2 14.6 0.0 0.0 0.0 17.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.2 0.0 0.0 0.0 0.0 28.2 20.5 0.0 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 43.0 10.0 0.0 0.0 0.0 0.0 0.0 0.0 35.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.7 0.0 0.0 0.0 0.0 17.6 4.4 0.0 0.0 0.0 POLR2A "POLR2, POLRA, RPB1" ENSG00000181222 "RNA polymerase II subunit A" 17 7484366-7514616 "Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 2.4;lymphoid tissue: 1.6" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "SCLC-21H: 3.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB012226, CAB016388, HPA021563, HPA053012" Enhanced Nucleoplasm,Cytosol NA Yes "Cluster 27: Non-specific - Gene expression" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm Cytosol "CAB012226: AB_304749, CAB016388: AB_677353, HPA021563: AB_1855526, HPA053012: AB_2682017" "unprognostic (2.03e-1)" "unprognostic (1.32e-1)" "unprognostic (1.58e-1)" "unprognostic (2.40e-1)" "unprognostic (1.71e-1)" "unprognostic (5.43e-2)" "unprognostic (8.77e-3)" "unprognostic (1.48e-1)" "unprognostic (5.19e-3)" "unprognostic (1.81e-1)" "unprognostic (1.52e-1)" "unprognostic (3.70e-2)" "unprognostic (1.01e-3)" "unprognostic (1.25e-1)" "unprognostic (2.30e-2)" "unprognostic (1.49e-1)" "unprognostic (4.70e-2)" 0.1 0.7 0.4 1.6 0.2 0.2 0.1 0.3 1.9 0.0 0.8 0.1 0.5 0.1 0.0 0.0 0.2 0.1 0.1 0.7 0.4 0.1 0.0 0.2 0.2 2.4 0.7 0.1 0.0 0.1 0.2 1.1 0.2 0.2 0.3 0.0 0.0 0.5 0.1 0.4 0.0 0.4 0.2 0.0 0.7 1.1 0.2 0.0 0.1 0.0 0.0 1.6 1.0 1.7 0.5 1.5 0.4 0.0 0.9 0.0 0.0 0.0 0.2 0.0 0.6 0.4 0.4 0.0 0.6 1.0 2.1 0.0 0.0 0.3 0.0 0.5 0.0 0.9 0.0 1.6 2.9 0.3 0.0 1.3 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.3 1.0 0.4 2.1 0.0 0.0 2.5 2.3 1.0 0.0 2.7 3.5 2.8 1.2 0.8 0.0 0.0 0.8 1.6 0.0 1.0 0.5 1.1 2.0 0.4 0.2 1.6 1.1 0.8 1.0 0.0 2.2 0.8 2.0 0.9 2.5 1.1 0.3 0.8 2.2 0.5 1.3 1.0 0.0 2.0 4.2 0.0 3.2 10.1 0.4 0.2 0.3 1.9 0.7 0.4 2.4 0.7 1.1 0.4 1.1 1.6 124.2 22.4 41.6 13.4 68.0 42.8 40.7 33.8 64.3 90.4 56.5 187.1 26.9 38.6 30.3 23.9 110.5 35.9 153.5 55.0 3.9 27.0 25.0 74.9 64.4 57.7 76.7 43.3 18.1 30.2 28.7 53.3 103.0 67.3 42.5 46.0 40.4 29.9 45.4 55.5 14.9 43.9 26.4 42.1 38.3 7.4 37.0 65.7 37.4 19.7 38.2 27.3 26.8 17.6 17.8 32.0 35.9 41.8 62.0 27.9 42.5 13.2 38.4 90.5 6.6 94.4 53.9 58.5 120.2 73.8 41.2 53.8 89.2 49.8 32.6 30.8 POLR2B RPB2 ENSG00000047315 "RNA polymerase II subunit B" P30876 4 56977722-57031158 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RNA polymerase related proteins" Transcription "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA037506 Approved Supported Nucleoplasm NA NA "Cluster 44: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" Nucleoplasm "HPA037506: AB_10672597" "unprognostic (9.88e-3)" "unprognostic (4.38e-2)" "unprognostic (1.83e-3)" "unprognostic (7.51e-2)" "unprognostic (2.30e-2)" "unprognostic (4.21e-3)" "unprognostic (1.24e-3)" "unprognostic (3.51e-1)" "unprognostic (6.39e-2)" "unprognostic (1.22e-1)" "unprognostic (1.23e-1)" "unprognostic (1.95e-1)" "prognostic favorable (7.17e-4)" "unprognostic (1.91e-1)" "unprognostic (1.51e-1)" "unprognostic (3.43e-1)" "unprognostic (7.35e-2)" 28.2 29.1 11.8 38.3 14.0 34.1 34.1 21.0 17.6 32.9 16.9 34.7 32.6 34.9 26.5 30.0 32.9 30.2 48.1 14.2 16.0 35.7 30.0 27.7 49.9 14.1 11.8 31.6 28.3 50.3 17.8 32.9 15.4 32.5 36.3 36.8 30.6 32.4 64.7 28.0 30.9 38.3 12.8 36.5 31.1 39.8 12.8 61.2 37.6 56.7 51.3 42.4 19.8 17.6 78.9 64.3 110.5 98.2 89.3 80.3 61.2 94.6 101.3 98.3 91.1 82.9 80.1 126.5 86.1 94.3 71.4 52.2 140.5 77.2 139.8 54.2 66.3 96.9 70.0 71.5 102.2 156.0 100.6 86.8 76.1 114.3 68.5 81.0 119.5 95.0 145.4 100.0 115.9 56.8 142.3 60.5 92.0 101.5 77.9 105.9 75.7 68.4 66.8 90.7 95.3 106.8 67.5 120.3 89.6 90.7 65.8 88.3 91.2 74.4 95.2 75.8 132.2 77.3 75.5 172.8 82.4 83.1 92.4 51.9 17.0 22.8 27.7 17.0 29.5 27.9 26.6 28.8 22.2 18.9 25.9 30.8 14.4 26.5 19.8 17.6 30.9 19.8 11.8 14.0 21.0 17.6 14.2 16.0 14.1 11.8 15.4 12.8 12.8 17.6 39.5 28.9 52.0 26.8 61.5 41.3 60.9 60.3 39.9 45.5 31.5 26.5 35.7 35.8 56.3 36.8 43.8 49.2 77.1 36.9 19.6 60.9 5.9 53.4 52.7 39.5 29.9 50.5 31.1 55.0 30.7 42.8 59.1 45.8 58.2 36.8 30.7 30.8 29.1 45.4 32.0 36.9 50.8 45.8 36.8 8.8 57.5 42.5 44.4 33.7 74.3 26.7 115.4 23.6 40.4 54.0 36.2 38.0 50.5 59.4 36.6 32.7 80.6 49.0 72.3 46.5 45.7 74.0 63.6 32.7 39.9 41.0 75.2 46.2 35.4 74.6 POLR2C RPB3 ENSG00000102978 "RNA polymerase II subunit C" P19387 16 57462660-57472009 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" Transcription "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040919, HPA041826" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 6: Non-specific - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm Cytosol "HPA040919: AB_10795483, HPA041826: AB_10793935" "unprognostic (2.10e-2)" "unprognostic (4.42e-2)" "unprognostic (7.52e-3)" "unprognostic (1.82e-2)" "unprognostic (1.34e-1)" "prognostic unfavorable (1.48e-4)" "unprognostic (2.90e-1)" "unprognostic (9.54e-2)" "unprognostic (1.95e-1)" "unprognostic (2.48e-2)" "unprognostic (2.60e-2)" "unprognostic (6.63e-2)" "prognostic favorable (3.03e-6)" "unprognostic (2.29e-1)" "unprognostic (2.31e-2)" "unprognostic (1.20e-1)" "unprognostic (5.43e-3)" 35.1 41.6 49.9 30.4 51.2 43.9 39.6 52.3 60.3 36.8 49.4 36.0 33.1 39.2 67.1 31.2 47.0 31.3 52.1 51.0 52.0 59.8 62.3 47.7 38.7 50.5 51.0 54.3 45.1 55.1 46.9 39.5 51.8 40.4 40.0 59.3 39.0 45.9 74.2 34.5 31.8 40.6 52.4 30.8 36.4 25.4 50.4 47.7 40.8 61.4 44.9 39.1 31.2 54.5 59.3 94.0 81.2 72.7 72.7 62.9 67.6 75.4 84.9 126.0 82.3 121.7 74.7 65.8 86.4 89.3 75.6 60.5 111.9 83.5 134.2 30.2 77.0 51.1 53.5 142.0 81.8 95.0 94.4 57.8 66.4 96.7 88.7 66.6 74.8 90.0 90.2 37.3 81.6 78.6 106.9 98.6 118.4 72.1 138.0 151.4 94.4 120.5 99.7 56.7 102.5 117.4 122.9 69.8 81.4 74.0 51.6 85.2 54.4 76.3 76.3 56.8 89.0 82.2 76.2 135.0 75.3 79.5 102.5 79.8 38.3 70.3 44.6 37.8 49.2 52.4 50.6 42.8 38.1 48.4 60.4 57.4 96.9 64.6 49.5 31.2 54.9 60.5 49.9 51.2 52.3 60.3 51.0 52.0 50.5 51.0 51.8 52.4 50.4 54.5 49.5 25.6 43.0 11.1 49.2 31.0 46.0 51.3 30.1 81.6 39.4 52.5 11.0 41.5 31.9 27.6 56.3 78.8 49.8 38.2 92.0 62.9 5.6 25.0 25.4 39.0 38.2 35.6 13.3 65.8 80.8 40.5 15.8 22.3 61.0 46.1 23.2 25.1 41.2 52.2 13.9 34.5 48.8 22.9 30.3 8.4 51.6 22.7 40.9 8.4 49.1 102.7 58.7 8.0 9.6 59.5 44.6 51.9 40.0 43.9 63.8 120.4 29.4 93.9 46.0 30.0 49.1 50.4 66.4 30.0 30.0 92.9 52.9 49.0 38.4 43.5 POLR2D RPB4 ENSG00000144231 "RNA polymerase II subunit D" O15514 2 127843553-127858155 "Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RNA polymerase related proteins" Transcription "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 74.3" "Cell type enhanced" "Detected in all" "Late spermatids: 170.2;Spermatocytes: 86.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034694, HPA046092" Approved Supported "Nucleoplasm,Nuclear speckles" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Nuclear speckles" "HPA034694: AB_2674284, HPA046092: AB_10963049" "unprognostic (3.57e-2)" "unprognostic (3.76e-2)" "unprognostic (2.59e-1)" "unprognostic (2.54e-2)" "unprognostic (2.77e-1)" "unprognostic (1.27e-1)" "prognostic unfavorable (8.91e-4)" "unprognostic (2.51e-1)" "unprognostic (7.95e-3)" "unprognostic (2.64e-3)" "unprognostic (1.97e-1)" "unprognostic (2.51e-1)" "prognostic unfavorable (2.79e-4)" "unprognostic (3.66e-2)" "unprognostic (6.57e-2)" "unprognostic (1.17e-1)" "unprognostic (2.38e-1)" 12.3 10.4 7.2 14.4 9.8 32.4 11.9 9.6 8.3 9.4 7.3 12.0 9.7 10.3 8.0 12.3 10.6 8.4 10.0 7.5 8.7 8.8 19.2 10.2 19.7 8.0 8.9 15.0 14.7 10.4 8.3 15.9 8.3 9.5 14.7 8.1 8.4 9.2 29.3 11.3 9.3 15.0 8.4 12.8 9.4 74.3 8.1 28.3 9.1 27.1 26.9 15.3 8.4 11.0 63.4 40.6 73.9 51.9 26.8 29.2 59.0 59.1 27.9 69.6 61.9 92.0 50.9 97.7 49.6 40.0 39.8 32.7 107.0 51.2 107.3 57.7 58.3 96.6 37.9 85.4 31.4 104.9 51.6 20.8 37.8 93.3 53.2 19.3 46.1 70.4 137.1 84.8 40.4 50.1 105.0 47.5 103.6 65.9 46.4 99.3 77.8 88.0 23.1 42.6 45.7 60.9 39.9 48.9 50.7 54.7 54.6 71.4 47.0 60.1 84.4 34.4 69.0 99.4 173.4 173.0 52.4 51.2 60.5 9.9 22.8 17.3 26.3 31.7 25.0 22.8 21.0 23.2 29.9 20.2 27.6 23.7 7.3 25.8 35.0 19.5 20.6 21.3 7.2 9.8 9.6 8.3 7.5 8.7 8.0 8.9 8.3 8.4 8.1 11.0 10.9 3.2 11.7 2.6 22.0 10.8 22.0 7.6 15.9 15.1 9.8 6.2 10.4 11.5 10.1 12.9 8.4 33.0 23.4 7.6 11.7 20.3 70.8 13.2 16.1 12.5 8.4 31.1 4.7 17.5 31.0 15.2 9.7 10.4 18.4 23.1 11.4 17.0 21.7 33.7 5.2 11.9 8.2 11.1 14.1 170.2 17.7 13.3 8.8 2.8 23.4 13.2 16.5 2.5 7.5 18.4 8.4 18.4 46.6 26.2 10.2 11.1 6.8 13.7 13.1 18.5 15.5 86.1 48.9 19.3 10.1 26.7 17.1 31.5 14.0 18.9 POLR2E "hRPB25, hsRPB5, RPABC1, RPB5, XAP4" ENSG00000099817 "RNA polymerase II, I and III subunit E" P19388 19 1086574-1095380 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" "Host-virus interaction, Transcription" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA063030, HPA068992" Supported Supported Nucleoplasm NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 3: Monocytes - Immune response regulation" Nucleoplasm "HPA063030: AB_2684926, HPA068992: AB_2686065" "unprognostic (2.52e-1)" "unprognostic (3.73e-2)" "unprognostic (2.49e-1)" "unprognostic (1.51e-2)" "unprognostic (2.14e-1)" "unprognostic (6.42e-2)" "unprognostic (2.59e-3)" "unprognostic (1.60e-1)" "unprognostic (2.08e-1)" "unprognostic (2.05e-1)" "unprognostic (2.03e-3)" "unprognostic (3.03e-2)" "prognostic favorable (3.21e-6)" "unprognostic (3.22e-1)" "unprognostic (1.47e-1)" "unprognostic (1.72e-3)" "unprognostic (4.77e-2)" 30.8 16.7 25.5 16.3 22.9 15.4 18.1 23.0 28.9 13.0 16.0 18.7 13.7 12.8 14.4 22.8 17.3 7.9 14.6 25.9 23.5 23.6 41.1 17.0 18.6 28.1 24.7 14.0 13.2 20.3 12.2 10.3 28.6 12.5 19.5 17.5 14.8 12.1 16.4 16.2 17.0 16.7 23.4 19.3 15.9 13.0 26.6 13.8 17.0 22.6 26.6 14.0 11.2 24.1 33.6 30.8 41.6 33.4 55.6 34.5 19.5 24.2 34.1 39.5 23.1 36.1 11.9 27.5 10.7 72.1 6.1 26.5 79.1 26.9 73.1 29.2 23.9 36.3 36.2 33.9 22.3 54.3 26.4 25.5 17.5 27.7 51.0 40.6 36.7 14.7 42.3 31.0 44.3 27.6 30.0 17.1 33.6 23.9 23.1 31.9 40.7 27.0 39.5 38.3 21.0 23.9 40.2 27.8 17.5 37.2 29.5 24.7 49.9 19.6 21.7 36.0 28.4 47.6 70.9 50.9 32.3 34.6 23.2 24.2 50.2 29.5 25.5 33.7 26.5 18.2 23.2 26.0 44.3 19.6 18.5 18.4 25.2 28.7 38.7 31.2 24.5 38.4 25.5 22.9 23.0 28.9 25.9 23.5 28.1 24.7 28.6 23.4 26.6 24.1 67.7 32.1 63.0 8.1 80.1 104.3 83.9 152.1 59.7 55.7 80.9 82.9 78.2 60.1 79.9 55.2 41.7 234.3 67.4 103.1 174.1 156.7 21.0 64.0 64.4 77.8 70.6 77.4 13.0 141.1 264.1 95.1 66.3 57.2 71.0 74.9 68.9 96.6 259.7 55.5 13.9 91.8 107.8 93.6 221.7 37.8 69.3 103.7 99.6 6.5 361.7 78.1 103.0 4.5 10.6 162.5 84.6 62.1 93.8 111.7 163.1 188.4 72.3 48.9 26.3 50.5 96.9 125.4 82.5 104.1 109.7 234.6 73.4 110.6 130.5 106.9 POLR2F "HRBP14.4, RPB6" ENSG00000100142 "RNA polymerase II, I and III subunit F" P61218 22 37952607-38041915 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" Transcription "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Cancer enriched" "Detected in single" 4 "melanoma: 1.5" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000827, CAB009882" Supported Supported "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Nucleoli fibrillar center" "CAB009882: AB_2299942, HPA000827: AB_1079834" "unprognostic (8.27e-2)" "unprognostic (7.50e-2)" "unprognostic (1.51e-3)" "unprognostic (1.43e-2)" "unprognostic (1.12e-1)" "unprognostic (1.35e-1)" "unprognostic (2.09e-1)" "unprognostic (2.73e-3)" "unprognostic (2.85e-1)" "unprognostic (5.87e-2)" "unprognostic (4.06e-1)" "unprognostic (1.40e-3)" "unprognostic (1.11e-4)" "unprognostic (9.08e-2)" "unprognostic (1.01e-1)" "unprognostic (2.90e-1)" "unprognostic (7.86e-2)" 52.5 61.1 73.4 34.6 92.3 38.9 50.8 77.5 90.2 59.5 56.9 64.9 37.7 53.2 24.8 58.7 50.2 19.5 91.8 74.2 91.2 58.2 118.6 41.6 31.0 87.9 83.9 60.9 47.5 76.5 62.7 30.2 82.6 47.7 28.7 16.8 56.1 39.6 111.0 45.8 42.3 28.8 75.3 36.4 57.6 48.8 86.8 36.7 54.7 68.4 26.3 53.1 52.7 123.7 150.7 176.2 120.6 128.7 141.1 81.7 109.4 138.0 81.0 141.4 130.5 210.0 51.8 117.4 99.1 120.3 138.3 106.4 166.9 135.7 67.1 143.0 303.7 107.3 181.3 289.1 125.9 213.6 67.0 112.4 99.8 186.3 72.1 71.2 118.7 130.4 208.9 93.7 101.9 220.2 168.4 258.2 174.3 175.4 134.7 162.3 110.4 134.5 77.4 94.8 180.6 67.2 129.5 88.9 215.3 69.6 62.9 144.3 110.5 119.8 173.9 150.4 158.1 106.0 178.0 247.9 122.4 107.9 138.4 118.9 92.9 140.8 83.8 90.4 78.5 95.8 71.9 81.8 86.3 71.3 63.1 63.7 122.8 113.7 78.5 123.3 103.4 85.3 73.4 92.3 77.5 90.2 74.2 91.2 87.9 83.9 82.6 75.3 86.8 123.7 82.6 38.5 85.9 9.4 73.2 204.3 113.9 205.4 63.7 26.7 133.8 168.7 0.3 101.5 122.5 121.4 25.0 243.5 70.5 148.7 193.7 160.0 117.0 96.0 117.2 94.8 117.2 109.6 9.9 159.5 303.4 97.4 58.1 82.4 90.0 90.0 98.6 304.4 178.5 28.6 10.7 143.1 116.0 94.2 102.9 42.0 159.7 65.9 225.9 2.8 102.3 99.4 111.2 9.5 99.0 182.4 152.9 151.2 65.7 137.3 196.6 306.5 114.3 33.3 157.8 90.1 197.1 237.0 241.0 106.0 224.3 211.9 82.4 82.7 145.7 121.2 POLR2G "hRPB19, hsRPB7, RPB7" ENSG00000168002 "RNA polymerase II subunit G" P62487 11 62761565-62766710 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" Transcription RNA-binding "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA053000 Approved Supported Nucleoplasm NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Nucleoplasm "HPA053000: AB_2682010" "unprognostic (7.58e-3)" "unprognostic (2.75e-1)" "unprognostic (2.37e-2)" "prognostic favorable (8.23e-4)" "unprognostic (1.39e-1)" "unprognostic (2.16e-2)" "prognostic unfavorable (6.02e-5)" "unprognostic (8.50e-2)" "unprognostic (6.01e-2)" "unprognostic (6.26e-3)" "unprognostic (9.41e-2)" "unprognostic (1.85e-1)" "prognostic unfavorable (1.11e-4)" "unprognostic (1.53e-1)" "unprognostic (1.64e-1)" "unprognostic (2.46e-1)" "unprognostic (2.21e-1)" 63.1 69.5 75.5 48.3 79.7 70.6 75.3 82.0 101.1 54.8 72.3 53.9 37.3 52.5 85.8 59.2 64.3 41.5 53.5 75.1 80.7 67.7 67.9 49.1 89.1 85.0 76.6 54.6 41.1 57.9 41.1 60.7 84.5 55.2 66.1 76.0 41.9 51.8 45.4 60.9 44.1 66.2 83.8 62.7 49.9 32.6 79.2 112.2 53.6 47.3 106.2 53.1 50.1 90.1 124.4 212.7 225.1 142.9 114.0 111.7 56.7 85.7 107.8 199.8 159.9 129.3 141.4 173.9 192.5 129.8 86.2 118.9 103.6 159.8 176.4 342.3 129.7 116.6 157.2 156.5 159.6 159.7 103.2 108.8 161.2 93.0 185.9 105.6 157.9 160.5 148.5 115.4 143.4 389.4 230.6 209.4 142.3 130.7 218.2 185.6 207.0 234.8 150.8 103.8 95.7 162.1 143.8 112.8 226.2 84.6 318.6 132.6 62.7 101.7 109.0 199.1 101.0 89.0 177.6 192.8 103.7 99.8 139.1 169.9 147.5 164.1 127.2 160.7 124.2 150.4 109.0 126.0 174.9 146.7 103.5 129.6 64.0 154.6 175.3 184.5 151.0 230.5 75.5 79.7 82.0 101.1 75.1 80.7 85.0 76.6 84.5 83.8 79.2 90.1 50.9 38.5 60.7 3.3 69.1 44.9 46.6 209.0 43.3 43.5 47.0 56.3 46.4 55.8 102.3 77.3 8.4 222.1 79.3 27.5 140.8 120.3 7.4 51.3 66.4 73.3 58.6 59.3 1.9 111.3 138.4 69.5 30.5 61.2 90.0 69.6 73.5 73.8 191.6 38.7 2.2 55.1 148.5 74.5 80.7 14.9 70.8 86.4 88.9 2.8 149.2 147.2 118.4 2.5 8.5 93.1 48.3 62.1 39.3 35.1 44.1 150.4 58.0 55.9 78.9 51.8 65.7 36.4 38.9 62.9 60.4 139.0 79.7 91.7 77.6 41.4 POLR2H RPB8 ENSG00000163882 "RNA polymerase II, I and III subunit H" P52434 3 184361718-184368596 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" Transcription DNA-binding "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037745, HPA055813" Supported Supported Nucleoplasm NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "HPA037745: AB_10672914, HPA055813: AB_2797254" "unprognostic (3.21e-1)" "unprognostic (4.96e-3)" "unprognostic (3.61e-3)" "unprognostic (7.15e-2)" "unprognostic (1.17e-2)" "unprognostic (6.72e-2)" "prognostic unfavorable (2.01e-4)" "unprognostic (8.82e-3)" "unprognostic (2.84e-1)" "unprognostic (4.02e-3)" "unprognostic (4.24e-2)" "unprognostic (1.27e-3)" "prognostic unfavorable (1.65e-10)" "unprognostic (1.34e-1)" "unprognostic (4.01e-1)" "unprognostic (1.71e-1)" "unprognostic (2.93e-3)" 41.6 60.6 50.4 32.5 51.0 31.1 42.2 53.5 60.1 48.8 51.8 54.4 57.6 36.3 39.7 52.1 39.8 30.0 34.8 50.7 49.9 77.5 63.8 37.6 41.1 50.8 50.6 40.2 52.1 35.5 32.9 34.9 50.9 42.9 57.8 14.6 44.2 26.3 37.3 37.8 55.5 35.0 49.8 41.9 51.2 32.3 51.3 39.8 48.3 30.0 40.8 43.4 41.5 52.9 225.2 77.3 81.7 121.4 89.0 62.8 101.2 82.8 86.3 110.8 141.6 199.6 104.6 126.0 201.7 65.0 168.4 88.8 147.4 148.7 98.1 124.4 194.7 121.4 89.8 126.2 80.1 129.3 67.9 81.6 83.3 72.6 129.8 99.4 116.3 124.6 95.3 81.0 89.0 265.6 128.7 172.3 89.0 279.0 159.3 74.3 74.9 171.2 133.9 100.3 122.8 87.3 69.7 214.0 126.9 78.6 267.9 102.4 61.5 52.5 82.9 70.9 224.3 161.7 181.3 237.3 83.4 136.2 71.5 8.3 17.6 15.9 26.8 30.7 32.9 32.9 31.6 29.1 34.0 33.9 45.8 34.8 1.3 29.8 19.2 34.7 36.7 21.6 50.4 51.0 53.5 60.1 50.7 49.9 50.8 50.6 50.9 49.8 51.3 52.9 45.1 38.5 43.8 23.8 39.4 113.4 74.1 113.7 61.5 22.0 70.1 77.0 17.4 47.1 70.2 44.1 16.7 103.2 45.8 132.8 140.8 73.0 21.0 62.3 62.3 57.9 55.7 53.8 12.9 91.2 146.0 52.8 53.5 83.7 31.1 50.4 43.2 58.5 61.4 25.2 15.8 80.2 93.6 21.4 57.5 14.3 46.0 29.9 51.6 9.4 29.0 26.7 32.0 8.5 11.5 97.6 90.9 27.8 52.1 139.7 94.5 150.5 55.1 24.9 39.5 48.0 69.6 92.9 111.0 66.0 74.2 122.3 38.0 71.6 83.1 92.5 POLR2I "hRPB14.5, RPB9" ENSG00000105258 "RNA polymerase II subunit I" P36954 19 36113709-36115213 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" Transcription "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 1145.8;Late spermatids: 2796.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035632, HPA045156" Uncertain Enhanced Nucleoplasm NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 80: Striated muscle - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 31: Spermatids - Spermatogenesis" Nucleoplasm "HPA035632: AB_2674711, HPA045156: AB_10964748" "unprognostic (1.95e-2)" "unprognostic (7.88e-3)" "unprognostic (3.54e-1)" "unprognostic (7.41e-3)" "unprognostic (2.05e-1)" "unprognostic (3.01e-1)" "unprognostic (1.24e-2)" "unprognostic (4.12e-2)" "unprognostic (7.39e-2)" "unprognostic (4.69e-3)" "unprognostic (2.86e-2)" "unprognostic (8.16e-2)" "unprognostic (1.83e-1)" "unprognostic (3.36e-2)" "unprognostic (3.84e-3)" "unprognostic (1.08e-1)" "unprognostic (1.16e-1)" 32.6 41.0 97.6 23.3 104.3 44.4 34.8 104.2 118.6 30.6 85.8 35.0 28.9 28.4 39.7 40.2 55.7 27.2 78.9 94.6 100.8 32.9 40.2 25.5 31.5 98.5 98.6 50.0 83.9 61.3 26.1 21.8 101.0 30.2 20.2 25.9 66.9 35.9 195.2 41.5 29.9 21.7 98.5 29.7 31.5 66.8 97.4 30.4 37.2 119.7 24.2 28.3 15.7 120.6 96.7 364.7 61.9 103.8 38.5 44.6 67.7 35.5 47.5 80.5 67.5 179.0 62.0 61.6 80.4 38.2 46.8 49.6 60.4 82.5 42.1 107.8 115.5 59.1 88.8 180.9 70.0 88.7 53.1 47.5 71.4 51.7 75.1 51.1 52.8 112.2 66.6 117.1 48.5 292.1 124.6 111.0 74.5 201.6 151.7 130.4 51.6 114.0 94.0 121.3 145.0 74.0 60.1 172.5 59.5 53.7 81.3 92.7 35.7 88.6 91.6 60.3 128.2 83.2 88.4 99.6 102.3 88.0 94.7 130.7 109.5 128.4 113.9 115.2 130.6 168.7 148.3 134.1 90.2 134.8 150.4 117.2 72.5 111.0 113.0 223.8 176.5 114.0 97.6 104.3 104.2 118.6 94.6 100.8 98.5 98.6 101.0 98.5 97.4 120.6 108.2 83.3 66.3 2.9 62.9 79.0 94.9 156.4 75.1 63.1 203.5 279.4 253.5 133.0 124.7 163.7 25.0 144.5 76.3 141.5 352.1 178.2 1145.8 380.4 114.9 101.6 106.2 199.9 2.9 240.5 166.2 96.9 71.4 126.0 82.4 150.0 111.0 282.5 124.3 33.7 3.2 163.3 126.1 72.9 63.8 2796.6 139.1 68.7 168.9 0.0 122.5 183.2 77.2 1.5 7.9 196.8 196.8 154.2 88.5 127.9 221.4 528.2 386.6 73.6 111.7 111.1 125.1 378.2 183.1 155.9 109.0 103.8 68.1 133.7 167.7 90.1 POLR2J "hRPB14, POLR2J1, RPB11, RPB11A, RPB11m" ENSG00000005075 "RNA polymerase II subunit J" P52435 7 102473118-102478907 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" Transcription "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" HPA046970 Approved Nucleoplasm NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 39: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "HPA046970: AB_2679882" "unprognostic (1.11e-1)" "unprognostic (1.24e-2)" "unprognostic (1.46e-2)" "unprognostic (1.62e-1)" "unprognostic (1.90e-2)" "unprognostic (4.80e-2)" "unprognostic (6.47e-2)" "unprognostic (4.26e-2)" "unprognostic (3.46e-1)" "unprognostic (1.53e-3)" "unprognostic (4.46e-2)" "unprognostic (7.32e-2)" "unprognostic (7.13e-2)" "unprognostic (2.45e-1)" "unprognostic (4.23e-2)" "unprognostic (1.37e-1)" "unprognostic (2.19e-2)" 54.8 87.0 85.3 36.5 87.4 90.0 51.7 88.2 108.0 48.3 83.2 59.1 46.4 48.1 54.7 60.0 46.5 32.7 125.8 85.3 89.6 71.2 99.4 43.3 46.1 89.2 87.2 59.3 58.6 62.9 66.4 32.5 87.4 59.7 33.9 17.8 58.6 38.2 195.7 56.5 51.1 28.3 88.3 59.1 63.6 43.6 90.2 53.2 56.0 127.7 40.1 51.1 48.1 88.4 143.4 143.0 96.2 127.5 89.2 68.5 70.4 77.4 82.3 111.2 94.2 131.1 108.4 65.7 145.9 108.7 160.2 74.8 89.8 95.6 67.8 123.3 160.4 65.9 101.2 129.1 108.9 128.5 94.6 89.6 117.4 100.1 55.8 72.5 100.8 138.3 156.8 190.0 92.5 439.6 212.9 228.5 89.5 141.4 182.2 100.1 94.4 194.0 91.2 93.6 81.4 135.6 93.5 176.1 113.9 97.3 79.1 155.3 82.3 125.0 160.0 198.4 154.5 116.5 183.6 171.0 111.3 157.8 149.1 180.3 116.5 199.5 90.5 122.5 86.2 137.6 96.0 101.0 93.8 122.9 81.4 81.8 174.6 84.7 115.5 127.5 140.8 128.9 85.3 87.4 88.2 108.0 85.3 89.6 89.2 87.2 87.4 88.3 90.2 88.4 87.9 35.3 46.7 17.9 91.1 95.0 113.5 190.7 79.1 37.0 149.6 195.2 193.2 81.5 107.4 125.0 12.5 197.7 93.0 241.7 273.9 139.0 53.1 84.1 64.4 86.8 103.0 128.2 5.6 199.6 195.5 94.4 78.0 73.2 43.7 90.7 86.0 203.5 202.5 35.3 6.2 164.0 146.5 111.0 107.6 43.2 127.1 99.5 142.3 4.7 154.0 171.3 127.7 8.5 10.8 191.8 281.6 110.6 111.4 128.9 236.3 242.0 107.0 46.7 52.6 76.9 113.2 117.1 229.3 114.3 116.1 182.1 91.4 114.5 131.2 153.9 POLR2K "RPB10alpha, RPB12" ENSG00000147669 "RNA polymerase II, I and III subunit K" P53803 8 100150623-100154003 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" Transcription "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" HPA047477 Supported "Nucleoli fibrillar center" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoli fibrillar center" "HPA047477: " "unprognostic (3.13e-2)" "unprognostic (1.52e-1)" "unprognostic (1.34e-1)" "unprognostic (1.15e-3)" "unprognostic (2.75e-2)" "unprognostic (4.68e-2)" "unprognostic (1.58e-2)" "unprognostic (1.62e-1)" "unprognostic (2.45e-1)" "unprognostic (1.57e-2)" "unprognostic (9.75e-3)" "unprognostic (5.73e-2)" "unprognostic (5.65e-2)" "unprognostic (3.46e-2)" "unprognostic (3.07e-2)" "unprognostic (9.16e-2)" "unprognostic (3.43e-2)" 55.2 73.7 65.1 40.9 67.7 66.8 70.4 70.2 110.9 55.3 62.9 51.4 37.7 49.6 71.2 45.0 39.8 41.6 63.8 67.3 72.1 74.5 69.9 48.6 57.9 68.9 67.8 43.4 33.9 80.8 48.4 48.1 69.1 52.1 54.0 61.3 47.5 54.2 45.5 37.3 38.8 47.0 69.0 42.7 47.2 33.2 67.8 64.1 63.3 58.7 58.2 61.4 36.0 70.7 152.7 75.8 95.3 67.3 100.3 91.0 63.9 109.9 90.5 110.1 132.6 46.7 101.5 100.7 214.7 87.8 64.1 67.8 103.4 91.1 144.3 164.8 114.5 138.3 88.8 100.4 79.1 90.3 95.2 74.6 119.0 87.3 88.7 71.1 101.4 116.6 109.7 96.0 108.6 96.5 228.0 132.5 98.9 216.5 148.1 88.7 55.1 146.5 138.4 84.5 199.3 130.1 75.6 65.9 169.9 92.1 134.7 136.0 78.7 64.1 92.3 100.4 119.0 98.1 169.2 160.6 121.8 156.3 102.4 72.5 33.3 50.4 47.8 44.6 58.3 65.6 61.5 60.5 43.1 46.7 54.1 57.9 12.6 58.0 42.5 67.4 70.3 55.7 65.1 67.7 70.2 110.9 67.3 72.1 68.9 67.8 69.1 69.0 67.8 70.7 120.5 67.3 57.8 8.8 101.3 162.6 162.9 263.8 82.6 57.5 115.9 123.3 93.4 82.9 152.2 147.1 16.7 134.7 126.5 75.0 440.3 146.0 6.3 113.1 80.9 101.5 122.1 95.9 18.2 130.1 197.0 105.2 60.1 95.2 109.2 52.1 79.2 122.7 154.1 48.8 17.9 116.9 213.6 72.2 103.9 17.6 117.1 78.6 136.9 8.4 144.3 115.7 122.6 12.1 17.4 141.3 72.0 121.5 127.2 224.7 108.1 388.5 127.8 64.9 72.3 96.8 148.0 139.1 166.6 103.0 170.1 137.6 127.9 92.9 98.8 261.3 POLR2L "hRPB7.6, hsRPB10b, RBP10, RPABC5, RPB10beta, RPB7.6" ENSG00000177700 "RNA polymerase II, I and III subunit L" P62875 11 837356-842529 "Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RNA polymerase related proteins" Transcription "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hepatocytes: 1813.6;Proximal tubular cells: 1989.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "A549: 569.0;PC-3: 706.8" "Low region specificity" "Detected in all" HPA073614 Supported Nucleoplasm NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 35: Non-specific - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm "HPA073614: " "unprognostic (2.65e-2)" "unprognostic (6.56e-3)" "unprognostic (1.40e-1)" "unprognostic (5.71e-2)" "unprognostic (3.49e-2)" "unprognostic (3.46e-2)" "prognostic unfavorable (2.37e-4)" "unprognostic (6.17e-3)" "unprognostic (1.34e-1)" "unprognostic (7.51e-3)" "unprognostic (2.37e-2)" "unprognostic (6.77e-2)" "prognostic favorable (5.56e-4)" "unprognostic (3.60e-2)" "unprognostic (1.32e-1)" "unprognostic (4.03e-3)" "unprognostic (1.73e-1)" 112.1 101.2 68.2 21.5 69.9 27.2 91.0 69.0 98.3 48.0 90.5 63.5 26.1 48.9 16.5 87.1 43.3 16.4 161.8 72.9 75.3 112.7 107.6 68.3 20.4 68.3 71.0 37.3 111.5 30.4 71.7 21.1 70.1 67.9 15.4 11.9 62.6 31.3 101.0 65.3 46.2 24.9 67.9 68.4 63.3 34.3 70.1 21.0 72.5 43.1 17.6 63.3 54.1 69.7 106.4 569.0 52.9 66.5 150.1 107.8 45.6 134.5 94.1 129.6 86.5 166.2 97.6 64.4 35.6 166.6 110.4 69.5 79.7 160.8 39.9 59.9 381.6 63.4 160.7 216.6 88.3 62.3 49.3 178.9 71.6 74.2 36.6 79.2 101.7 63.9 67.0 71.3 156.1 268.4 59.7 63.1 82.6 124.7 706.8 58.8 41.9 99.3 160.7 81.1 104.1 32.1 133.3 135.2 107.3 28.2 81.2 36.7 117.9 87.5 69.1 48.3 83.8 40.0 50.0 62.3 130.8 58.3 78.2 93.3 119.5 121.7 92.9 109.0 100.1 75.5 86.0 92.0 114.0 73.6 71.8 89.3 32.1 123.7 76.6 141.1 92.5 134.7 68.2 69.9 69.0 98.3 72.9 75.3 68.3 71.0 70.1 67.9 70.1 69.7 364.4 410.3 390.2 9.8 265.9 611.8 245.0 767.6 279.4 68.1 491.1 412.0 500.6 584.8 415.4 526.0 25.0 625.4 305.0 669.3 1287.4 444.0 84.2 388.4 377.2 400.3 501.7 363.4 5.0 684.1 467.7 392.3 283.4 301.7 266.2 194.4 649.6 1813.6 700.2 50.5 5.3 641.6 323.5 434.5 582.0 235.7 305.7 307.3 658.1 11.2 493.6 368.5 389.3 3.5 9.0 751.1 589.2 255.1 382.8 300.0 813.6 1989.1 329.9 82.5 157.8 195.2 340.8 182.6 268.6 459.8 696.6 449.6 286.1 284.9 553.1 289.7 POLR3A "C160, hRPC155, RPC1, RPC155" ENSG00000148606 "RNA polymerase III subunit A" O14802 10 77969251-78029515 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RNA polymerase related proteins" "Antiviral defense, Immunity, Innate immunity, Transcription" "Nucleotidyltransferase, Transferase" "Disease variant, Leukodystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 64.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "PC-3: 75.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA037926 Uncertain Supported Nucleoplasm NA NA "Cluster 42: Non-specific - Transcription" "Cluster 58: Brain - Synaptic function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 9: Photoreceptor cells - Phototransduction" Nucleoplasm "HPA037926: AB_10672400" "unprognostic (6.83e-2)" "unprognostic (3.41e-2)" "unprognostic (4.54e-2)" "unprognostic (2.76e-2)" "unprognostic (6.41e-2)" "unprognostic (1.75e-1)" "prognostic unfavorable (3.64e-6)" "unprognostic (3.25e-1)" "unprognostic (1.07e-1)" "unprognostic (1.73e-1)" "unprognostic (6.64e-2)" "unprognostic (2.09e-2)" "unprognostic (1.51e-2)" "unprognostic (1.34e-1)" "unprognostic (3.19e-1)" "unprognostic (1.30e-1)" "unprognostic (4.11e-2)" 4.3 6.0 6.6 5.2 7.1 3.9 6.2 6.7 7.9 5.1 4.7 4.8 5.1 5.5 7.5 5.0 4.8 3.7 4.9 8.1 3.7 5.2 5.6 4.0 5.7 5.5 3.4 6.5 5.4 6.8 10.4 6.1 5.5 5.8 5.7 12.8 5.0 4.5 11.5 6.7 4.7 5.6 2.2 5.1 4.7 6.0 4.0 7.6 5.6 8.7 6.3 5.0 4.8 6.5 14.2 16.3 17.4 28.8 11.2 14.2 11.6 16.0 20.7 20.2 19.8 22.1 10.0 17.6 9.7 14.0 11.5 15.7 30.3 17.5 24.4 13.0 22.2 14.2 13.6 26.6 10.5 24.6 11.5 12.2 12.3 35.9 33.0 19.4 18.0 14.1 26.8 10.6 19.9 10.6 18.7 15.6 19.0 11.0 75.1 17.5 11.0 11.5 10.0 8.6 15.5 20.0 15.4 28.3 16.6 15.5 21.0 12.7 19.8 12.9 12.5 14.2 32.0 16.4 18.6 21.0 23.0 25.4 6.4 5.4 2.6 1.5 3.5 3.1 3.5 2.6 2.8 3.4 2.4 3.2 2.5 3.0 1.5 3.4 2.9 2.6 4.6 1.9 6.6 7.1 6.7 7.9 8.1 3.7 5.5 3.4 5.5 2.2 4.0 6.5 8.5 0.0 9.1 17.0 8.7 9.9 5.1 5.3 11.4 28.3 9.6 8.3 11.7 8.6 9.5 0.0 64.6 8.0 12.6 6.1 1.9 7.0 1.6 8.3 14.4 8.1 7.2 11.6 26.4 6.2 6.9 8.2 8.2 8.9 6.3 15.7 5.3 9.5 5.5 15.2 26.3 10.2 0.0 6.9 3.7 1.2 13.1 5.9 1.8 10.3 7.8 13.0 12.3 16.1 18.7 8.1 8.3 8.2 11.2 4.7 8.0 5.0 10.4 31.5 6.6 13.6 8.3 12.5 18.0 10.1 9.1 4.1 7.8 13.7 8.6 3.6 POLR3B "C128, FLJ10388, RPC2" ENSG00000013503 "RNA polymerase III subunit B" Q9NW08 12 106357748-106510198 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RNA polymerase related proteins" "Antiviral defense, Immunity, Innate immunity, Transcription" "Nucleotidyltransferase, Transferase" "Disease variant, Leukodystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Inhibitory neurons: 24.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036466 Supported Approved "Nuclear speckles" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" "Nuclear speckles" "HPA036466: AB_10671842" "unprognostic (1.17e-1)" "unprognostic (1.52e-1)" "unprognostic (4.80e-2)" "unprognostic (1.37e-2)" "unprognostic (1.13e-1)" "unprognostic (2.73e-1)" "unprognostic (4.21e-2)" "unprognostic (1.12e-1)" "unprognostic (1.33e-1)" "unprognostic (3.36e-2)" "unprognostic (6.11e-2)" "unprognostic (5.09e-2)" "prognostic favorable (1.21e-4)" "unprognostic (1.54e-1)" "unprognostic (1.46e-1)" "unprognostic (8.73e-2)" "unprognostic (9.24e-2)" 4.5 8.7 3.1 4.8 4.4 5.2 5.0 4.3 4.6 4.7 3.7 5.3 4.2 4.6 5.2 8.6 5.1 3.6 5.8 3.4 2.9 6.8 9.0 4.7 4.1 2.2 2.3 7.5 4.9 11.1 2.4 6.7 2.3 5.6 5.7 6.2 4.7 4.0 6.5 11.0 3.4 5.4 2.7 3.3 5.4 6.1 3.2 4.7 6.0 8.3 5.6 4.9 4.3 3.6 16.2 7.6 16.4 7.8 13.9 13.1 22.9 21.9 13.0 15.2 11.6 14.0 4.4 20.6 7.7 14.2 5.6 14.8 19.5 19.2 18.5 16.6 13.1 15.7 10.1 12.0 9.2 26.1 17.0 11.7 13.4 15.1 17.3 10.3 11.5 9.8 24.5 6.5 11.2 12.0 19.1 8.7 17.8 11.9 28.5 11.6 9.8 13.5 8.6 21.8 17.3 9.6 13.6 18.2 13.4 10.8 17.0 7.9 11.0 8.3 10.0 13.6 13.1 8.1 22.4 30.3 3.8 15.9 9.2 5.6 2.0 1.5 2.0 2.2 2.7 2.1 2.2 2.2 2.6 1.3 3.0 1.9 1.3 2.1 2.2 0.9 2.7 1.7 3.1 4.4 4.3 4.6 3.4 2.9 2.2 2.3 2.3 2.7 3.2 3.6 2.4 0.0 9.2 14.4 4.7 1.8 1.7 4.5 4.6 6.0 3.4 3.7 10.3 2.8 7.0 5.5 6.2 11.0 3.8 3.8 1.9 5.1 7.1 3.9 7.0 3.3 4.2 3.8 22.3 4.6 9.3 4.4 9.2 3.9 5.1 4.8 3.6 11.0 3.1 3.3 24.1 5.6 2.0 1.6 0.3 5.2 3.7 2.4 3.6 9.4 1.0 2.4 2.1 17.1 22.4 3.8 1.1 4.9 4.9 1.5 1.7 3.4 7.2 7.2 6.6 6.9 4.1 16.5 10.9 8.9 3.0 7.4 4.1 7.2 5.1 1.2 POLR3C "C82, RPC3, RPC62" ENSG00000186141 "RNA polymerase III subunit C" Q9BUI4 1 145824088-145844402 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" "Antiviral defense, Immunity, Innate immunity, Transcription" DNA-binding "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 16 "Early spermatids: 288.2;Late spermatids: 574.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027508, HPA027516" Uncertain Enhanced Nucleoplasm NA NA "Cluster 44: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 34: Spermatids - Unknown function" Nucleoplasm "HPA027508: AB_10600091, HPA027516: AB_10600894" "unprognostic (1.43e-2)" "unprognostic (1.70e-2)" "unprognostic (2.97e-2)" "prognostic unfavorable (1.56e-4)" "unprognostic (6.87e-2)" "unprognostic (1.73e-1)" "prognostic unfavorable (5.48e-4)" "unprognostic (2.51e-1)" "prognostic unfavorable (1.50e-4)" "unprognostic (1.13e-1)" "unprognostic (1.41e-2)" "unprognostic (4.46e-1)" "prognostic unfavorable (1.85e-5)" "unprognostic (2.34e-1)" "unprognostic (4.95e-2)" "unprognostic (1.07e-2)" "unprognostic (1.38e-1)" 16.9 8.5 5.0 10.5 5.3 14.7 15.1 8.7 6.5 14.1 4.6 12.0 8.0 13.4 9.3 11.1 12.3 10.9 10.1 5.5 4.9 10.3 10.7 9.7 14.1 4.6 4.6 16.0 14.6 11.9 6.3 10.4 5.1 9.6 11.2 7.9 12.4 8.3 14.7 15.9 11.8 13.1 4.7 12.6 11.3 24.8 5.3 15.3 11.4 10.3 15.6 13.0 12.2 6.5 29.9 23.7 19.0 17.6 23.0 29.3 19.8 30.6 31.5 36.2 34.9 32.6 16.4 51.6 28.9 37.2 19.5 31.6 30.6 30.5 34.9 22.7 24.9 27.9 26.5 17.6 42.1 58.4 35.2 29.3 18.9 42.4 61.7 20.8 21.8 22.0 36.3 30.9 35.6 37.2 27.7 22.1 29.0 29.3 29.7 30.1 23.6 34.1 19.7 20.6 18.2 26.4 26.0 37.5 36.7 28.5 29.5 49.6 26.7 34.0 27.4 19.6 41.9 42.9 48.1 58.8 12.4 28.4 28.3 63.0 31.7 31.9 22.5 36.9 29.5 30.4 24.2 23.3 33.9 33.8 25.1 22.7 2.7 34.0 27.0 35.6 23.3 26.1 5.0 5.3 8.7 6.5 5.5 4.9 4.6 4.6 5.1 4.7 5.3 6.5 12.6 6.4 10.8 12.1 15.6 5.0 8.3 8.8 13.1 3.6 5.5 5.2 23.8 2.8 10.1 3.7 4.2 11.7 18.5 3.5 11.7 14.8 288.2 7.8 7.3 11.2 4.2 19.1 13.0 21.3 12.5 11.0 9.2 7.5 8.2 6.9 9.3 5.2 14.3 1.7 12.4 7.5 8.2 12.6 6.2 574.5 10.2 9.4 1.8 10.3 13.3 5.1 10.3 14.1 12.9 16.5 6.8 14.7 12.2 8.4 8.9 12.8 8.1 3.8 19.7 11.0 9.9 26.1 22.5 10.9 4.3 9.6 13.4 11.1 8.5 9.5 POLR3D "BN51T, C53, RPC4, TSBN51" ENSG00000168495 "RNA polymerase III subunit D" P05423 8 22245133-22254601 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" "Antiviral defense, Immunity, Innate immunity, Transcription" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA061331, HPA067875, HPA068461, HPA069089" Supported Enhanced Nucleoplasm NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm "HPA061331: AB_2684480, HPA067875: AB_2685912, HPA068461: AB_2685993, HPA069089: AB_2686081" "unprognostic (2.33e-1)" "unprognostic (2.27e-1)" "unprognostic (9.38e-3)" "unprognostic (9.33e-3)" "unprognostic (1.24e-1)" "unprognostic (8.02e-2)" "prognostic unfavorable (1.21e-4)" "unprognostic (2.02e-1)" "unprognostic (2.19e-2)" "unprognostic (3.27e-1)" "unprognostic (8.03e-2)" "unprognostic (2.20e-1)" "prognostic unfavorable (9.15e-6)" "unprognostic (1.15e-1)" "unprognostic (3.13e-1)" "unprognostic (6.93e-2)" "prognostic unfavorable (2.12e-4)" 15.0 11.9 3.4 4.4 3.3 6.5 10.6 3.0 3.9 14.1 3.8 11.3 2.5 10.4 3.3 15.2 11.3 4.1 14.1 3.0 3.6 11.7 10.0 11.1 4.7 3.7 3.6 14.9 17.5 4.0 13.7 6.6 3.6 12.8 4.5 4.0 10.6 3.8 32.8 11.2 8.6 5.8 3.5 11.4 10.6 19.3 3.9 3.4 10.6 8.3 4.3 15.1 14.4 4.3 5.1 10.7 11.0 7.8 10.0 16.6 11.3 18.9 9.1 10.7 8.7 10.5 3.6 27.8 10.2 12.5 8.9 9.1 16.9 9.2 11.0 6.9 9.4 20.7 10.5 11.2 13.6 5.0 9.5 13.8 12.9 13.4 21.8 13.1 8.9 14.9 28.9 9.5 8.7 7.2 22.2 10.4 18.9 13.0 9.0 14.7 12.2 18.0 6.1 6.0 7.8 24.2 8.5 5.9 17.7 11.9 5.4 8.0 13.0 9.4 9.1 18.8 11.4 17.0 22.7 18.9 9.2 10.1 14.0 0.1 1.4 0.3 1.8 1.1 2.5 2.4 2.3 2.6 1.6 2.2 3.0 1.9 0.1 2.9 1.6 3.5 1.8 1.3 3.4 3.3 3.0 3.9 3.0 3.6 3.7 3.6 3.6 3.5 3.9 4.3 15.0 9.6 6.5 4.6 15.8 19.5 43.6 21.2 13.6 12.8 15.2 14.5 10.9 4.3 13.3 11.0 16.7 16.2 18.5 6.9 11.7 20.2 42.7 11.6 37.7 15.6 21.5 10.3 2.4 11.8 33.2 21.3 12.8 14.8 18.4 18.7 11.7 3.8 13.7 3.3 2.8 19.1 12.2 8.8 8.2 40.5 15.8 8.6 8.8 1.0 13.4 4.5 14.4 2.5 3.5 22.5 6.7 12.8 20.5 52.3 6.7 12.6 11.2 12.2 19.7 22.1 21.3 44.2 52.0 12.1 19.2 27.0 15.0 25.1 12.3 41.8 POLR3E "C37, FLJ10509, RPC5, SIN" ENSG00000058600 "RNA polymerase III subunit E" Q9NVU0 16 22297375-22335101 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" "Antiviral defense, Immunity, Innate immunity, Transcription" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 62.6" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041419, HPA041477" Approved Enhanced Nucleoplasm Yes No "Cluster 39: Non-specific - mRNA processing" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 24: Non-specific - Transcription regulation" Nucleoplasm "HPA041419: AB_2677468, HPA041477: AB_10796345" "unprognostic (3.09e-2)" "unprognostic (8.59e-2)" "unprognostic (8.23e-2)" "unprognostic (1.04e-1)" "unprognostic (1.51e-1)" "unprognostic (7.28e-2)" "unprognostic (2.42e-2)" "unprognostic (7.73e-2)" "unprognostic (2.96e-2)" "unprognostic (1.34e-1)" "unprognostic (2.03e-1)" "prognostic unfavorable (1.74e-4)" "unprognostic (8.14e-2)" "unprognostic (1.91e-1)" "unprognostic (8.96e-2)" "unprognostic (8.19e-3)" "unprognostic (3.41e-2)" 12.2 17.0 2.8 6.6 4.5 7.8 12.0 4.3 3.7 10.7 16.1 12.9 6.3 12.7 2.4 13.0 11.8 4.5 15.4 4.1 4.4 8.4 13.3 10.2 5.3 4.8 5.5 11.3 16.1 10.7 12.8 4.6 4.5 11.3 3.0 3.1 12.2 8.2 62.6 14.8 10.0 4.9 3.7 8.9 14.2 11.2 4.2 8.5 12.8 15.5 5.7 12.0 10.4 5.3 21.1 29.0 6.9 19.5 12.1 9.7 27.5 16.1 6.1 9.4 4.2 36.3 14.8 41.7 21.8 11.1 7.9 18.7 35.6 20.6 7.6 28.7 52.3 21.0 31.8 70.9 15.1 34.4 23.0 8.7 19.5 22.1 25.8 3.5 25.9 17.1 63.1 17.0 10.9 34.5 33.6 11.8 37.5 20.2 22.8 45.0 16.7 54.2 8.0 12.4 28.9 20.6 15.6 29.2 14.0 4.2 17.2 16.3 17.3 11.0 12.4 9.2 18.3 23.6 45.6 40.3 11.1 23.0 21.1 0.0 4.7 2.8 8.6 4.8 9.1 7.4 9.1 8.7 7.7 6.0 8.4 7.3 0.5 7.4 4.5 4.4 10.0 6.9 2.8 4.5 4.3 3.7 4.1 4.4 4.8 5.5 4.5 3.7 4.2 5.3 9.4 3.2 14.7 14.4 20.3 32.5 23.0 10.9 12.5 24.0 16.4 19.7 18.9 11.5 13.4 18.4 31.3 25.2 27.3 8.9 5.9 12.0 34.9 21.0 13.3 13.3 15.0 10.5 12.8 12.8 20.2 14.1 13.7 28.5 27.9 23.1 8.9 11.1 13.1 20.2 16.3 13.7 10.2 10.1 22.2 20.9 12.5 11.0 14.2 11.2 9.7 10.4 21.6 18.6 17.9 15.0 11.7 9.1 26.0 28.5 13.6 11.8 16.6 40.9 13.1 21.0 12.2 19.7 16.1 16.5 39.6 28.3 30.3 20.5 16.2 26.3 POLR3F "C34, RPC39, RPC6" ENSG00000132664 "RNA polymerase III subunit F" Q9H1D9 20 18467389-18484646 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" "Antiviral defense, Immunity, Innate immunity, Transcription" DNA-binding "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 42.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA049441, HPA050173, HPA072298" Uncertain Approved Nucleoplasm NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 77: Retina - Visual perception" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 23: Spermatids - Flagellum & Golgi organization" Nucleoplasm "HPA049441: AB_2680768, HPA050173: AB_2681042, HPA072298: AB_2686510" "unprognostic (4.59e-2)" "unprognostic (1.83e-1)" "unprognostic (3.44e-1)" "unprognostic (1.69e-2)" "unprognostic (1.55e-1)" "unprognostic (7.39e-2)" "prognostic unfavorable (8.87e-9)" "unprognostic (1.80e-1)" "unprognostic (1.50e-1)" "unprognostic (2.20e-1)" "prognostic favorable (6.48e-4)" "unprognostic (3.04e-1)" "unprognostic (4.01e-1)" "unprognostic (3.28e-1)" "unprognostic (1.79e-1)" "unprognostic (2.88e-3)" "unprognostic (4.98e-3)" 6.6 6.5 10.1 6.4 10.9 9.8 9.5 13.1 12.6 6.1 9.7 5.2 5.0 8.0 9.5 7.0 6.8 5.7 9.8 11.1 10.5 8.5 6.4 6.2 7.3 10.1 10.0 8.2 6.0 7.6 3.2 7.5 10.5 7.0 6.1 21.2 5.7 6.6 10.9 7.4 4.4 7.2 9.9 6.3 5.5 9.1 9.9 6.9 11.0 9.5 7.2 6.9 3.0 10.9 12.9 12.6 14.9 15.9 9.5 11.7 22.7 19.0 13.2 23.8 19.3 14.0 12.1 12.0 10.0 14.2 21.3 20.0 20.8 21.2 27.2 8.1 11.0 8.5 7.1 18.6 12.4 22.8 11.9 10.6 14.0 32.2 18.0 13.1 12.9 9.4 19.4 11.7 19.0 15.8 17.3 21.1 17.2 14.3 29.1 11.8 29.4 12.7 13.0 9.1 27.3 17.2 13.9 24.2 32.2 14.0 13.6 15.5 10.1 26.0 13.4 16.2 27.8 11.2 38.0 11.7 10.7 11.0 19.5 0.4 3.0 1.3 2.7 3.7 4.5 3.1 3.6 2.7 3.7 1.7 3.5 3.6 0.8 3.7 3.0 2.7 3.7 2.7 10.1 10.9 13.1 12.6 11.1 10.5 10.1 10.0 10.5 9.9 9.9 10.9 7.3 9.6 4.8 9.8 8.0 8.9 3.7 5.7 10.2 18.3 6.6 5.8 8.3 2.8 5.1 1.8 10.4 10.7 8.5 3.5 9.8 8.8 42.7 8.5 6.7 9.0 6.7 8.2 21.7 6.8 12.1 7.0 4.6 4.8 5.7 8.8 7.1 4.6 7.6 11.8 19.4 4.4 4.1 9.2 6.7 7.7 6.2 5.9 5.4 10.3 10.4 17.5 12.3 15.1 13.0 7.7 1.9 10.1 9.0 4.3 2.9 12.2 11.3 19.3 13.1 8.3 8.3 28.1 22.9 8.4 11.4 7.3 8.0 11.3 4.3 3.2 POLR3G "C31, RPC32, RPC7" ENSG00000113356 "RNA polymerase III subunit G" O15318 5 90471748-90514557 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" "Antiviral defense, Immunity, Innate immunity, Transcription" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 24.8;Inhibitory neurons: 21.2;Oligodendrocytes: 70.8;Spermatogonia: 26.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "WM-115: 84.5" "CAB010109, HPA052658, HPA074330" Enhanced Supported "Nucleoplasm,Nuclear bodies,Cytosol" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 6: Brain - Smell perception" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "Nuclear bodies, Cytosol" "CAB010109: AB_2165718, HPA052658: AB_2681904, HPA074330: " "unprognostic (4.31e-1)" "unprognostic (5.35e-2)" "unprognostic (2.62e-2)" "unprognostic (3.55e-3)" "unprognostic (1.18e-1)" "unprognostic (3.42e-2)" "unprognostic (4.19e-6)" "unprognostic (2.17e-3)" "unprognostic (1.91e-1)" "unprognostic (1.93e-2)" "unprognostic (3.52e-2)" "unprognostic (9.71e-2)" "unprognostic (1.21e-14)" "unprognostic (3.86e-2)" "unprognostic (3.19e-2)" "unprognostic (1.53e-2)" "unprognostic (8.17e-5)" 1.8 0.6 3.5 2.4 4.5 3.0 2.0 6.3 5.9 1.3 0.7 1.6 1.8 1.5 4.7 4.3 1.2 1.3 1.8 3.6 6.0 0.9 2.2 1.6 4.7 5.7 4.4 1.9 2.4 2.0 0.9 1.8 6.8 1.7 1.5 3.3 2.3 0.5 3.0 4.3 1.4 0.8 1.9 1.8 1.2 4.5 4.2 0.8 3.2 0.8 1.9 2.0 1.7 6.3 24.1 13.0 18.8 5.3 5.9 8.2 7.7 11.9 4.3 19.8 16.8 9.0 18.8 63.7 4.2 5.3 20.0 11.6 20.8 23.2 69.2 29.6 19.6 26.2 8.1 15.1 9.5 19.4 6.2 6.7 8.1 32.7 25.8 4.6 27.2 26.5 35.8 6.4 8.3 13.2 19.1 14.1 78.1 4.0 63.2 16.5 7.4 40.2 5.9 3.2 22.0 6.4 3.7 9.6 35.1 7.7 5.4 6.2 29.1 10.3 21.2 13.2 48.3 13.5 36.7 50.0 22.1 23.7 84.5 3.3 0.2 0.2 1.5 0.4 0.7 1.7 0.5 0.9 0.4 0.9 1.1 1.2 0.7 2.9 1.5 1.0 0.2 0.3 3.5 4.5 6.3 5.9 3.6 6.0 5.7 4.4 6.8 1.9 4.2 6.3 3.2 6.4 2.2 11.8 2.8 3.6 1.6 1.5 1.8 3.0 2.8 3.7 5.2 0.0 0.7 1.8 8.4 0.8 0.7 0.9 3.9 2.4 4.5 1.6 2.3 2.0 6.7 8.8 24.8 4.4 5.4 3.8 0.5 1.2 7.0 1.6 4.6 2.6 1.7 3.3 21.2 1.4 0.0 0.3 0.3 1.0 0.3 1.2 1.8 5.6 0.0 1.1 1.0 14.6 70.8 4.1 3.0 1.2 5.4 6.1 0.4 1.5 3.0 0.8 0.0 1.1 1.8 7.2 26.6 6.3 8.5 0.8 1.7 6.5 2.0 0.8 POLR3GL "flj32422, MGC3200" ENSG00000121851 "RNA polymerase III subunit GL" Q9BT43 1 145964690-145978848 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "NK-cells: 196.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" HPA027288 Uncertain NA NA "Cluster 44: Non-specific - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 63: NK-cells & T-cells - Immune response" "HPA027288: AB_10602119" "prognostic favorable (2.96e-4)" "unprognostic (3.58e-3)" "unprognostic (1.55e-2)" "prognostic favorable (6.52e-5)" "unprognostic (2.88e-1)" "unprognostic (1.19e-1)" "unprognostic (2.23e-1)" "unprognostic (1.37e-2)" "unprognostic (4.15e-2)" "unprognostic (2.11e-1)" "unprognostic (5.98e-3)" "unprognostic (1.42e-1)" "unprognostic (1.08e-2)" "unprognostic (9.96e-2)" "unprognostic (3.61e-1)" "unprognostic (1.82e-1)" "unprognostic (1.42e-1)" 50.3 42.0 33.4 26.5 33.9 28.7 41.9 32.7 42.9 29.8 33.9 41.2 19.8 30.2 27.7 20.1 31.4 21.0 67.7 32.6 35.9 31.7 55.2 31.7 40.5 34.9 33.8 36.2 21.1 31.4 33.3 19.8 33.6 28.7 25.0 28.3 26.2 24.6 139.8 26.9 36.7 24.4 33.1 46.6 33.6 19.8 34.4 41.1 33.7 66.1 41.6 32.7 25.1 33.9 28.5 12.6 28.6 26.4 70.3 78.8 6.9 28.3 43.9 19.0 28.6 3.9 31.0 60.9 41.4 39.6 15.4 8.6 14.1 27.7 28.8 66.8 15.5 40.6 10.6 19.8 43.2 41.1 55.3 60.1 18.1 31.2 36.0 55.5 50.5 64.2 68.9 51.5 73.1 30.5 33.6 51.4 5.9 42.9 27.8 27.8 35.3 92.8 30.6 6.5 15.5 28.8 40.0 2.6 58.3 23.2 24.8 65.5 52.7 17.7 11.7 35.0 19.3 83.9 27.4 47.4 32.1 48.5 16.4 225.8 53.8 266.1 124.2 73.3 119.0 118.4 125.3 123.2 56.0 110.0 126.7 130.6 41.2 116.2 79.0 44.1 179.5 103.5 33.4 33.9 32.7 42.9 32.6 35.9 34.9 33.8 33.6 33.1 34.4 33.9 69.8 28.9 52.8 12.1 63.0 27.9 27.5 52.4 15.9 32.3 34.8 37.8 83.7 52.9 35.7 20.2 8.4 19.9 76.0 35.1 123.3 35.2 38.8 21.9 24.7 51.4 21.1 46.7 6.5 38.6 26.5 40.1 21.9 15.5 85.4 35.6 60.7 84.3 70.2 57.2 7.9 31.1 63.1 70.0 46.6 11.2 45.1 54.9 58.7 10.3 73.1 84.9 196.7 4.0 9.3 38.6 33.8 47.0 48.2 20.1 31.6 41.2 42.7 20.9 26.3 32.6 40.5 22.9 29.4 25.2 30.0 9.4 94.6 50.0 33.1 24.6 POLR3H "C25, KIAA1665, RPC8" ENSG00000100413 "RNA polymerase III subunit H" Q9Y535 22 41525799-41544606 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" "Antiviral defense, Immunity, Innate immunity, Transcription" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 163.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046787 Approved Supported Nucleoplasm,Vesicles,Centrosome NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "Vesicles, Centrosome" "HPA046787: AB_2679806" "unprognostic (1.55e-1)" "unprognostic (6.74e-2)" "unprognostic (1.06e-1)" "unprognostic (3.87e-3)" "unprognostic (9.57e-2)" "unprognostic (1.26e-1)" "prognostic unfavorable (2.04e-4)" "unprognostic (2.05e-2)" "unprognostic (1.33e-2)" "unprognostic (5.43e-2)" "prognostic favorable (5.41e-4)" "unprognostic (6.40e-2)" "unprognostic (1.54e-1)" "unprognostic (2.94e-2)" "unprognostic (1.49e-1)" "unprognostic (4.00e-2)" "unprognostic (1.70e-1)" 16.6 21.0 40.4 8.5 38.9 5.4 15.1 38.0 49.5 11.0 33.3 13.4 4.8 14.0 9.0 16.4 15.8 7.9 18.3 39.5 38.6 13.5 26.7 14.2 10.0 41.1 41.7 18.5 12.2 11.9 18.2 6.5 38.1 15.4 5.2 7.0 11.5 10.7 13.8 12.1 9.7 11.7 40.1 10.9 13.4 16.2 41.3 8.0 14.1 9.0 7.7 14.2 9.8 39.4 36.4 23.8 21.4 32.7 23.0 20.9 14.8 30.5 27.3 49.0 39.3 47.9 12.0 30.8 21.9 49.9 27.8 17.8 39.8 48.1 30.6 26.3 50.1 18.4 37.1 23.7 23.9 75.3 30.8 26.3 30.8 64.9 17.4 18.8 23.5 29.3 39.5 19.9 28.0 34.4 19.3 20.1 15.6 49.8 28.1 30.0 16.9 32.6 22.9 21.7 21.2 12.5 37.0 39.7 19.3 13.7 15.6 21.1 22.7 29.8 30.7 49.8 39.8 16.7 28.6 46.6 49.5 26.8 28.9 0.1 12.5 0.2 8.8 18.3 12.6 16.6 8.7 10.4 14.2 13.9 11.6 9.7 0.6 5.4 18.6 13.3 5.8 9.9 40.4 38.9 38.0 49.5 39.5 38.6 41.1 41.7 38.1 40.1 41.3 39.4 6.1 0.0 32.0 15.7 14.8 17.7 12.0 19.0 13.6 18.8 24.9 23.4 6.4 14.3 19.8 16.5 16.7 32.9 7.9 5.0 46.9 30.4 42.6 12.7 15.4 10.3 14.3 19.1 10.0 29.6 30.9 14.8 13.3 8.9 11.4 13.1 9.7 33.3 30.5 21.9 7.1 4.8 14.2 9.5 11.0 163.9 16.8 10.2 24.9 1.9 19.6 24.1 18.6 2.0 6.7 27.6 6.6 20.3 21.8 16.8 4.1 40.7 12.7 20.9 0.0 17.9 16.8 51.6 50.9 21.2 25.6 17.9 10.3 21.2 9.5 11.8 POLR3K "C11, RPC11" ENSG00000161980 "RNA polymerase III subunit K" Q9Y2Y1 16 46407-53608 "Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins" "Antiviral defense, Immunity, Innate immunity, Transcription" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 183.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005891 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm Cytosol "HPA005891: AB_1079653" "unprognostic (3.00e-1)" "unprognostic (1.50e-3)" "unprognostic (1.53e-1)" "unprognostic (7.16e-3)" "unprognostic (1.47e-1)" "unprognostic (1.40e-1)" "unprognostic (8.03e-3)" "unprognostic (9.06e-2)" "unprognostic (7.40e-2)" "unprognostic (5.72e-2)" "unprognostic (9.96e-2)" "unprognostic (1.84e-1)" "unprognostic (7.36e-3)" "unprognostic (2.68e-2)" "unprognostic (3.63e-2)" "unprognostic (3.53e-2)" "unprognostic (9.63e-2)" 6.9 10.4 12.5 13.1 13.0 11.6 7.0 12.3 13.5 6.4 11.0 8.1 8.3 6.8 7.3 8.7 7.4 5.2 10.3 12.6 12.8 8.2 9.0 6.5 18.4 11.8 11.9 7.1 6.9 12.3 6.1 6.7 12.5 8.0 7.6 5.1 8.4 6.8 20.5 5.3 8.5 6.7 11.5 11.9 8.4 2.6 13.6 13.1 9.5 12.6 16.3 8.8 5.8 13.2 36.1 60.9 37.7 39.4 15.2 9.4 30.3 50.2 16.0 43.4 28.7 79.4 38.2 93.1 37.1 17.7 17.3 35.0 88.5 23.0 31.0 56.5 82.1 68.2 44.5 56.6 11.6 62.1 64.3 9.2 20.4 48.3 24.3 9.9 21.7 40.9 99.0 29.0 28.4 89.9 75.1 41.2 62.3 44.8 57.4 89.9 43.7 96.7 25.0 25.7 55.1 32.5 34.7 63.2 30.8 15.9 37.2 55.2 20.9 28.1 34.5 37.8 61.6 18.5 47.5 183.8 12.1 45.1 42.5 30.5 36.3 93.2 40.4 54.7 42.1 114.6 51.3 46.5 34.4 109.9 45.8 42.6 27.7 41.2 51.8 70.2 87.6 53.1 12.5 13.0 12.3 13.5 12.6 12.8 11.8 11.9 12.5 11.5 13.6 13.2 23.3 3.2 11.3 2.0 31.8 33.3 19.9 34.4 17.6 16.4 29.7 33.8 28.9 18.6 30.3 18.4 4.2 42.5 28.2 17.6 49.0 34.0 0.7 21.6 15.6 20.0 18.0 38.3 5.1 35.0 51.1 16.9 9.2 14.9 22.2 29.7 20.7 27.5 43.7 10.1 4.6 21.8 71.2 15.1 24.3 1.8 21.1 23.2 23.2 3.7 44.1 23.5 34.0 1.0 3.4 37.0 16.2 16.6 28.1 29.6 17.1 43.4 30.6 10.8 13.1 12.0 25.2 4.5 18.9 23.4 44.2 12.9 23.1 58.8 29.3 22.1 POLRMT "APOLMT, h-mtRPOL, MTRNAP, MTRPOL" ENSG00000099821 "RNA polymerase mitochondrial" O00411 19 617221-633537 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transcription "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 84.0;Spermatogonia: 84.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006366 Uncertain Supported Mitochondria NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 21: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" Mitochondria "HPA006366: AB_1079654" "unprognostic (3.24e-1)" "unprognostic (4.31e-2)" "unprognostic (7.96e-2)" "prognostic favorable (4.50e-4)" "unprognostic (9.46e-2)" "unprognostic (2.94e-2)" "unprognostic (3.04e-2)" "unprognostic (9.41e-2)" "unprognostic (1.45e-1)" "unprognostic (3.48e-1)" "unprognostic (7.64e-3)" "unprognostic (1.81e-2)" "unprognostic (1.62e-1)" "unprognostic (1.28e-3)" "unprognostic (1.66e-1)" "unprognostic (2.92e-1)" "unprognostic (1.01e-1)" 17.2 23.9 19.5 9.1 20.5 6.8 18.1 20.7 28.5 19.3 16.9 22.3 14.5 19.7 10.0 21.0 19.2 5.3 38.0 20.1 17.5 26.2 41.3 16.0 9.6 24.4 20.4 20.7 26.3 11.4 22.7 5.0 21.3 20.7 7.2 5.7 17.2 9.2 69.2 27.9 23.9 6.6 17.8 22.5 21.8 66.6 20.9 11.0 20.1 14.9 7.5 21.5 17.7 24.4 24.5 43.6 9.7 42.1 19.7 11.0 35.7 11.1 12.9 15.7 14.5 44.2 15.9 24.9 22.0 10.2 7.9 24.5 35.5 21.0 11.8 28.3 86.8 19.3 26.4 56.9 20.5 32.6 34.7 10.7 29.3 16.4 19.7 11.3 22.9 34.0 37.3 23.6 14.8 34.3 43.7 44.7 38.4 31.1 30.2 42.0 13.3 42.4 21.4 20.7 30.7 22.1 10.2 26.7 28.4 10.3 15.4 29.9 14.1 17.2 22.0 26.9 33.3 57.4 51.0 38.7 36.9 27.3 21.8 0.0 2.9 2.5 6.2 3.8 5.0 5.6 4.6 4.6 5.5 6.3 3.9 4.5 0.5 6.0 4.2 5.4 3.1 4.6 19.5 20.5 20.7 28.5 20.1 17.5 24.4 20.4 21.3 17.8 20.9 24.4 10.3 12.8 11.5 2.6 14.2 8.0 6.1 5.8 10.2 18.3 9.1 8.0 18.0 15.7 7.9 16.5 18.8 15.5 13.3 31.5 7.9 6.7 39.8 7.7 6.1 9.7 13.1 9.4 2.7 8.0 8.7 8.9 14.3 8.6 12.7 15.1 8.2 21.9 10.4 11.8 2.7 12.7 4.1 8.3 7.4 84.0 12.5 8.0 10.6 3.7 7.4 8.4 18.6 1.5 4.6 6.5 12.4 13.2 7.8 10.3 26.0 15.1 6.4 18.1 6.6 8.9 10.0 31.6 84.9 10.6 7.2 7.7 12.7 15.6 24.4 6.2 RAD1 "HRAD1, REC1" ENSG00000113456 "RAD1 checkpoint DNA exonuclease" O60671 5 34905260-34918989 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair" "Exonuclease, Hydrolase, Nuclease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006692 Approved Approved Nucleoplasm,Vesicles NA Yes "Cluster 6: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 20: HeLa - Mitochondria" "Cluster 47: Cytotrophoblasts - Unknown function" "Nucleoplasm, Vesicles" "HPA006692: AB_2667645" "prognostic unfavorable (6.30e-4)" "unprognostic (1.85e-2)" "unprognostic (9.40e-2)" "unprognostic (1.98e-3)" "unprognostic (2.00e-1)" "unprognostic (2.38e-2)" "prognostic unfavorable (1.06e-5)" "unprognostic (1.22e-2)" "unprognostic (2.25e-3)" "unprognostic (1.61e-3)" "unprognostic (2.57e-1)" "unprognostic (2.57e-1)" "unprognostic (2.22e-2)" "unprognostic (1.36e-1)" "unprognostic (1.72e-1)" "unprognostic (2.11e-1)" "unprognostic (3.12e-3)" 3.5 8.1 3.2 4.8 3.5 8.4 5.8 3.9 4.6 6.8 5.3 4.1 4.9 5.6 5.4 4.9 3.9 4.6 8.9 3.8 4.6 5.1 4.3 7.5 8.9 3.5 2.7 5.7 4.4 5.1 3.5 8.1 3.2 6.8 4.3 8.7 4.9 4.8 10.9 6.7 4.8 4.6 1.9 4.9 4.8 7.9 3.4 6.3 6.3 8.6 6.2 5.2 4.7 3.8 8.5 10.2 12.3 20.5 7.9 9.4 17.2 15.1 12.0 13.0 10.6 12.2 12.3 25.0 5.2 11.2 15.7 8.4 12.6 7.6 14.4 10.1 12.7 12.9 34.0 8.0 11.9 16.5 11.9 7.8 7.3 13.9 9.3 6.1 6.2 11.0 22.7 13.2 11.2 10.2 19.6 13.9 15.4 6.0 15.7 17.1 24.0 8.6 6.7 9.0 12.4 13.3 30.0 19.9 13.3 7.6 12.5 14.8 6.2 17.9 13.3 9.7 14.4 7.9 13.8 20.3 11.1 28.6 12.5 7.4 2.9 6.5 5.3 2.8 6.9 8.6 5.8 7.6 3.1 9.1 8.2 6.8 1.6 4.5 2.8 6.9 4.9 2.6 3.2 3.5 3.9 4.6 3.8 4.6 3.5 2.7 3.2 1.9 3.4 3.8 11.5 22.4 43.2 5.9 18.3 29.2 20.2 29.3 13.1 25.3 23.9 18.4 25.7 14.3 21.3 20.2 27.1 82.3 20.4 11.9 19.6 18.1 22.0 13.1 16.6 14.1 13.1 28.2 6.6 22.5 54.4 18.7 6.1 12.0 21.5 39.1 10.0 14.8 23.4 23.5 9.0 12.7 30.5 12.0 19.3 16.8 25.1 13.1 17.8 6.5 12.7 23.9 9.2 7.5 9.1 17.8 13.8 21.8 18.0 21.9 13.4 16.4 14.6 35.6 13.1 19.6 19.4 72.5 58.6 15.6 28.6 80.6 22.3 27.4 13.0 25.8 RAD9A RAD9 ENSG00000172613 "RAD9 checkpoint clamp component A" Q99638 11 67317871-67398410 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage" "Exonuclease, Hydrolase, Nuclease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006725, HPA048155, CAB079979" Enhanced Enhanced "Nucleoplasm,Nuclear bodies" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 71: Testis - DNA repair" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "Nuclear bodies" "CAB079979: , HPA006725: AB_1856041, HPA048155: AB_2680290" "unprognostic (7.64e-2)" "prognostic favorable (6.95e-4)" "unprognostic (8.83e-3)" "unprognostic (1.13e-1)" "unprognostic (2.68e-1)" "unprognostic (2.12e-3)" "unprognostic (9.64e-3)" "unprognostic (1.05e-2)" "unprognostic (1.23e-1)" "unprognostic (1.97e-1)" "unprognostic (9.19e-2)" "unprognostic (2.50e-2)" "prognostic unfavorable (2.82e-5)" "unprognostic (6.16e-2)" "unprognostic (3.72e-3)" "unprognostic (2.19e-1)" "prognostic favorable (7.52e-6)" 5.8 5.0 3.3 6.9 3.6 10.2 6.9 2.1 6.0 9.2 2.9 7.3 10.9 7.4 2.1 9.0 10.9 5.7 4.2 3.8 2.4 7.1 6.6 6.7 8.3 2.9 3.6 8.0 8.0 3.4 10.1 4.4 2.2 10.8 3.0 1.8 9.8 6.1 5.2 11.4 11.1 2.4 2.2 9.4 8.4 8.6 2.5 6.1 9.7 2.1 3.7 6.5 8.5 2.2 10.8 15.8 9.5 13.8 2.8 1.1 12.0 5.7 4.9 8.0 7.1 23.2 20.9 11.1 12.4 1.8 13.0 18.7 6.0 5.5 0.9 13.0 16.3 16.8 8.5 10.4 3.8 12.3 20.3 3.2 5.3 7.2 3.5 6.1 5.5 23.2 14.7 15.6 2.3 33.2 21.9 21.8 13.2 15.9 12.1 18.8 12.5 13.6 2.2 9.0 9.8 10.6 9.9 27.2 21.1 2.4 19.1 10.9 4.2 11.7 14.3 23.3 8.7 14.6 14.2 11.5 7.5 11.6 9.6 5.3 1.8 6.0 5.2 2.3 3.8 4.3 4.1 4.3 1.2 3.1 2.9 3.2 2.8 3.1 2.5 3.4 2.4 1.5 3.3 3.6 2.1 6.0 3.8 2.4 2.9 3.6 2.2 2.2 2.5 2.2 16.0 22.4 17.1 10.1 31.0 17.1 17.7 17.9 23.3 19.6 19.7 18.4 1.1 12.8 22.2 20.2 70.9 27.9 31.3 54.2 13.7 11.3 27.3 32.1 13.4 16.3 14.3 17.7 8.5 13.1 22.4 13.8 27.0 14.9 20.3 26.0 11.0 6.6 15.1 21.9 6.0 48.9 10.2 10.3 31.4 13.2 10.5 14.0 19.6 11.2 8.9 15.0 56.7 2.5 5.3 11.6 31.6 12.4 38.5 16.6 61.8 10.9 44.0 32.1 13.1 10.5 14.5 32.0 17.6 18.3 17.3 40.6 30.3 15.3 38.7 18.0 REV3L "POLZ, REV3" ENSG00000009413 "REV3 like, DNA directed polymerase zeta catalytic subunit" O60673 6 111299028-111483715 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication" "DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 28.8" "Cell type enhanced" "Detected in all" "Astrocytes: 290.6;Endometrial stromal cells: 610.1;Inhibitory neurons: 360.2;Oligodendrocyte precursor cells: 594.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA064853, HPA069382" Uncertain Approved Nucleoplasm NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 77: Retina - Visual perception" "Cluster 18: U-2197 - ECM organization" "Cluster 36: Stromal cells - Cell proliferation" Nucleoplasm "HPA064853: AB_2685369, HPA069382: AB_2686134" "unprognostic (5.54e-2)" "unprognostic (2.06e-1)" "unprognostic (5.09e-2)" "unprognostic (1.71e-1)" "unprognostic (1.59e-1)" "unprognostic (8.59e-3)" "unprognostic (4.42e-2)" "unprognostic (1.56e-2)" "unprognostic (8.09e-2)" "unprognostic (1.17e-1)" "unprognostic (6.87e-3)" "unprognostic (1.27e-1)" "unprognostic (4.34e-2)" "unprognostic (2.80e-1)" "unprognostic (1.67e-1)" "unprognostic (1.67e-1)" "unprognostic (1.03e-3)" 6.1 3.6 11.2 6.4 9.2 7.2 3.1 28.8 11.9 16.6 11.3 4.8 4.3 10.3 2.3 4.6 6.2 4.9 4.4 7.2 10.0 4.1 3.5 4.4 5.6 3.6 7.9 7.6 4.2 3.2 0.9 6.8 4.4 4.8 3.5 26.2 3.2 5.0 5.0 4.7 3.6 8.0 1.8 4.6 4.5 7.5 8.4 6.0 6.6 12.2 2.5 4.8 1.0 10.7 9.2 6.3 11.4 13.3 35.2 35.0 11.9 13.6 16.7 6.4 9.6 8.1 5.0 17.0 9.3 15.9 12.0 9.4 17.6 5.7 10.7 13.9 10.0 13.9 13.9 13.3 9.1 13.5 6.9 21.0 3.2 12.0 15.4 10.3 10.2 10.0 18.3 13.9 10.8 7.2 16.7 3.6 3.2 3.8 10.2 11.6 12.7 6.6 2.5 7.9 15.7 11.8 17.5 3.2 12.4 8.5 7.1 14.2 13.7 9.6 9.6 47.0 15.4 14.0 17.1 17.6 9.1 10.5 12.4 0.6 0.6 1.2 1.0 0.5 1.6 1.0 0.8 1.0 0.6 1.6 0.5 1.0 1.9 0.4 0.9 0.9 0.7 0.3 11.2 9.2 28.8 11.9 7.2 10.0 3.6 7.9 4.4 1.8 8.4 10.7 133.4 48.1 82.4 290.6 65.7 30.5 19.5 12.8 45.5 117.5 20.2 17.9 34.5 11.5 29.1 20.2 56.3 27.2 35.3 11.8 3.9 17.3 40.0 151.1 610.1 57.4 59.8 27.5 161.7 11.5 11.9 82.7 41.3 107.5 46.9 61.5 21.8 16.0 11.8 35.3 360.2 18.6 10.2 19.9 87.4 16.3 50.4 57.2 21.4 105.9 23.7 59.6 33.0 594.7 190.3 8.5 12.3 39.1 41.3 21.3 18.4 15.9 43.5 57.6 39.5 122.3 62.3 68.5 70.4 26.1 26.9 33.0 46.4 30.3 21.5 8.2 RFC5 RFC36 ENSG00000111445 "Replication factor C subunit 5" P40937 12 118013588-118033130 "Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA replication" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Erythroid cells: 45.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041037 Supported Approved Nucleoplasm NA NA 6500 "Cluster 44: Non-specific - Transcription" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "HPA041037: AB_10805834" "unprognostic (9.63e-2)" "prognostic favorable (8.05e-5)" "unprognostic (5.12e-3)" "unprognostic (2.25e-2)" "unprognostic (1.06e-2)" "unprognostic (2.16e-2)" "unprognostic (1.40e-3)" "unprognostic (1.10e-1)" "unprognostic (2.35e-3)" "unprognostic (1.42e-1)" "unprognostic (1.05e-1)" "unprognostic (2.81e-2)" "prognostic unfavorable (2.30e-4)" "unprognostic (1.44e-1)" "unprognostic (2.15e-1)" "unprognostic (2.70e-1)" "unprognostic (5.06e-1)" 5.9 5.8 3.7 10.5 4.4 33.8 10.7 5.9 4.9 8.6 4.2 10.3 9.8 11.1 5.4 9.3 9.5 6.7 5.4 6.0 2.9 8.7 13.0 6.8 16.4 3.3 3.2 15.6 7.6 7.1 4.7 7.3 3.2 7.9 12.6 11.5 5.8 8.0 5.6 12.9 9.1 7.7 3.8 8.0 7.2 8.3 3.7 23.4 10.3 4.7 16.1 6.3 7.1 4.3 52.8 49.3 49.1 28.1 12.2 14.7 58.3 38.4 24.0 66.6 49.9 50.2 21.4 56.4 25.9 18.1 42.0 47.2 66.9 34.0 63.2 42.1 58.1 43.9 40.7 36.5 7.6 70.7 38.1 7.8 12.2 50.0 16.8 30.4 28.6 70.3 62.6 21.6 33.3 50.3 93.2 59.2 40.5 29.8 46.1 68.1 61.2 55.3 30.7 47.7 67.5 30.7 62.2 18.2 24.1 30.4 64.4 30.0 13.7 36.9 42.5 50.4 69.5 36.2 51.7 76.9 36.4 51.7 66.1 16.6 5.0 3.6 8.6 8.4 7.6 10.7 10.3 7.4 7.2 9.1 8.0 6.9 5.6 7.9 4.9 6.0 11.4 6.5 3.7 4.4 5.9 4.9 6.0 2.9 3.3 3.2 3.2 3.8 3.7 4.3 4.0 0.0 3.3 4.6 5.6 8.4 6.9 7.1 4.0 4.2 5.2 4.7 3.1 4.3 4.6 9.2 2.1 21.0 4.7 3.6 9.8 8.9 3.0 6.0 6.3 4.3 4.2 45.7 11.8 6.3 25.2 6.4 4.1 6.5 5.7 14.0 3.3 6.0 9.1 1.7 7.3 6.9 4.1 3.2 3.1 2.7 4.1 4.9 0.0 3.7 3.8 9.5 2.1 2.5 5.5 4.1 4.0 8.2 16.4 2.3 3.2 6.6 11.0 6.0 0.0 5.3 8.4 13.4 9.1 9.5 5.4 8.9 7.9 18.7 10.6 4.2 TENT2 "FLJ38499, GLD2, PAPD4, TUT2" ENSG00000164329 "Terminal nucleotidyltransferase 2" Q6PIY7 5 79612120-79686648 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "mRNA processing" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "dendritic cells: 37.6;Glandular and luminal cells: 33.2;Granulosa cells: 31.9;Hofbauer cells: 33.9;Syncytiotrophoblasts: 33.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054468 Approved Cytosol No No "Cluster 27: Non-specific - Gene expression" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 7: Non-specific - Mitochondria" Cytosol "HPA054468: AB_2682497" "unprognostic (1.52e-1)" "unprognostic (2.17e-1)" "unprognostic (6.25e-3)" "unprognostic (1.91e-1)" "unprognostic (8.03e-2)" "unprognostic (2.80e-3)" "unprognostic (2.10e-2)" "unprognostic (1.10e-1)" "unprognostic (6.80e-2)" "unprognostic (1.57e-3)" "unprognostic (9.37e-2)" "unprognostic (2.21e-1)" "unprognostic (7.71e-2)" "unprognostic (2.38e-1)" "unprognostic (8.43e-3)" "unprognostic (5.84e-3)" "unprognostic (2.67e-3)" 19.1 15.1 10.4 20.4 12.8 44.4 25.0 11.5 15.6 17.9 15.0 18.5 17.8 19.6 23.6 16.5 16.0 17.3 14.5 9.6 10.8 17.6 23.8 17.9 30.2 12.0 11.1 22.7 15.2 15.5 11.5 21.0 12.5 15.7 20.8 14.3 15.1 15.3 16.2 23.8 19.1 18.3 10.9 27.8 17.7 17.5 11.2 27.2 22.4 14.3 28.1 19.1 15.9 15.2 22.5 15.3 16.8 26.7 28.8 33.2 26.8 26.6 40.6 30.5 48.3 13.8 26.1 41.8 13.6 29.6 35.9 21.1 21.8 29.6 34.6 31.3 19.9 23.9 19.4 21.6 37.3 35.7 31.6 29.5 31.4 21.6 40.1 29.7 26.2 30.0 27.7 30.0 34.0 12.3 40.8 45.6 15.6 17.0 10.8 36.2 16.8 47.2 29.4 31.8 11.0 20.1 21.1 22.8 42.8 26.4 19.6 55.6 24.2 16.4 11.1 16.0 29.9 31.3 27.8 40.7 28.9 36.8 23.4 30.7 21.5 21.6 19.0 24.8 31.3 21.6 20.5 21.0 21.9 17.2 19.5 20.6 19.2 21.8 26.0 12.0 23.4 19.0 10.4 12.8 11.5 15.6 9.6 10.8 12.0 11.1 12.5 10.9 11.2 15.2 25.9 0.0 0.0 0.0 14.0 0.0 0.0 0.0 0.0 0.0 24.2 16.5 0.0 0.0 0.0 27.6 0.0 26.3 37.6 0.0 17.6 10.2 0.0 21.3 29.0 7.2 0.0 0.0 0.0 10.2 22.6 8.7 0.0 33.2 0.0 31.9 0.0 0.0 33.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.9 0.0 0.0 9.8 0.0 0.0 0.0 0.0 14.9 0.0 0.0 11.5 0.0 0.0 26.5 0.0 0.0 0.0 0.0 9.0 0.0 0.0 0.0 0.0 33.7 11.0 23.7 0.0 0.0 TENT4A "LAK-1, PAPD7, POLK, POLS, TRF4, TRF4-1" ENSG00000112941 "Terminal nucleotidyltransferase 4A" Q5XG87 5 6713432-6757044 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "mRNA processing" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 19.3;Breast glandular cells: 13.4;Breast myoepithelial cells: 13.2;dendritic cells: 12.3;Endometrial stromal cells: 15.4;Glandular and luminal cells: 14.0;Granulosa cells: 14.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045487, HPA046742" Enhanced Supported "Nucleoplasm,Nuclear membrane,Golgi apparatus" NA NA "Cluster 35: T-regs - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 20: HeLa - Mitochondria" "Cluster 65: Plasmacytoid DCs - Unknown function" Nucleoplasm "Nuclear membrane, Golgi apparatus" "HPA045487: AB_2679346, HPA046742: AB_2679781" "unprognostic (1.45e-1)" "unprognostic (2.96e-1)" "unprognostic (2.08e-2)" "unprognostic (2.12e-3)" "unprognostic (7.57e-2)" "unprognostic (1.30e-2)" "unprognostic (4.22e-2)" "unprognostic (2.37e-1)" "unprognostic (2.62e-1)" "unprognostic (9.78e-2)" "unprognostic (3.10e-3)" "unprognostic (3.73e-2)" "prognostic unfavorable (7.99e-5)" "unprognostic (6.56e-2)" "unprognostic (2.08e-1)" "unprognostic (2.60e-2)" "prognostic favorable (8.55e-4)" 13.1 8.1 8.4 9.5 8.6 27.6 11.0 16.6 10.1 12.5 5.7 10.0 8.7 11.1 6.4 10.7 11.5 10.0 8.5 8.7 8.1 9.6 20.5 12.8 13.0 6.5 6.5 15.6 12.0 10.0 11.1 9.1 7.0 11.1 7.2 12.5 8.2 8.8 9.3 15.7 12.4 12.2 6.0 13.7 9.6 10.1 7.9 14.6 10.2 12.1 10.4 10.1 11.8 8.9 31.7 20.9 25.4 31.6 17.7 15.6 37.0 21.0 25.7 25.1 28.2 21.9 17.3 23.1 16.1 25.5 28.5 22.9 20.7 16.4 23.1 26.1 14.0 12.0 72.5 12.4 11.0 18.0 17.3 10.7 13.8 28.7 18.4 18.6 15.0 16.9 16.3 29.8 20.8 17.6 24.4 25.3 13.6 9.7 16.6 21.8 21.2 6.0 10.5 17.5 25.1 19.3 50.7 24.1 14.5 13.4 14.5 9.9 13.6 30.6 32.7 27.2 29.8 28.6 12.6 20.4 19.6 16.4 19.2 0.0 0.2 0.2 0.6 0.1 0.6 0.5 0.4 0.4 0.3 0.4 0.5 0.5 0.1 0.1 0.2 1.1 0.6 0.2 8.4 8.6 16.6 10.1 8.7 8.1 6.5 6.5 7.0 6.0 7.9 8.9 19.3 0.0 0.0 0.0 7.3 0.0 0.0 0.0 0.0 0.0 13.4 13.2 0.0 0.0 0.0 5.5 0.0 5.3 12.3 0.0 1.9 4.9 0.0 10.7 15.4 4.8 0.0 0.0 0.0 4.4 4.0 4.0 0.0 14.0 0.0 14.5 0.0 0.0 6.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.8 0.0 0.0 4.2 0.0 0.0 0.0 0.0 6.6 0.0 0.0 8.4 0.0 0.0 2.5 0.0 0.0 0.0 0.0 6.2 0.0 0.0 0.0 0.0 5.6 4.8 10.7 0.0 0.0 TK1 ENSG00000167900 "Thymidine kinase 1" P04183 17 78174091-78187233 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA synthesis" "Kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 77.9" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 92.8;Erythroid cells: 108.6;Extravillous trophoblasts: 210.4;Hofbauer cells: 65.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "T-reg: 34.0" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Region enhanced" "Detected in some" "white matter: 3.6" "Low region specificity" "Detected in many" CAB004683 Enhanced NA Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "CAB004683: AB_437067" "unprognostic (7.09e-2)" "unprognostic (1.17e-3)" "unprognostic (1.82e-1)" "unprognostic (2.14e-3)" "unprognostic (3.22e-1)" "unprognostic (1.94e-1)" "prognostic unfavorable (6.87e-4)" "prognostic unfavorable (3.03e-5)" "unprognostic (4.05e-2)" "unprognostic (3.18e-3)" "unprognostic (6.64e-3)" "unprognostic (2.76e-2)" "prognostic unfavorable (6.50e-11)" "unprognostic (5.55e-3)" "unprognostic (1.92e-1)" "unprognostic (1.42e-1)" "unprognostic (4.94e-2)" 3.7 2.7 2.5 20.4 3.4 77.9 5.9 3.6 3.4 5.9 1.3 24.4 18.0 3.0 0.2 27.2 4.9 3.4 2.8 2.7 2.4 11.0 9.2 9.1 34.8 3.4 3.3 1.3 5.6 0.6 0.6 14.8 3.3 3.4 15.7 0.1 6.3 1.5 5.5 14.2 18.3 10.1 2.6 12.4 17.9 3.1 3.8 25.1 2.0 1.6 30.6 5.5 9.0 4.4 443.9 357.7 68.2 92.5 7.6 28.0 47.3 207.6 113.2 323.1 442.3 324.2 178.7 144.1 72.9 131.7 133.9 204.2 63.4 187.1 158.0 51.2 230.4 252.5 119.9 213.3 2.2 107.1 162.9 13.8 7.1 166.1 22.5 22.3 137.9 49.4 156.7 311.9 130.8 352.0 56.0 68.6 36.7 259.1 240.9 152.6 276.4 324.1 90.6 138.5 33.6 94.2 162.0 481.2 59.7 59.4 303.9 156.1 57.8 302.3 305.7 219.9 292.1 132.5 71.4 181.9 149.0 71.9 142.1 0.0 1.1 0.0 1.8 2.1 0.7 5.8 7.9 4.0 3.4 1.7 0.4 2.2 1.8 10.8 1.7 1.1 34.0 5.5 2.5 3.4 3.6 3.4 2.7 2.4 3.4 3.3 3.3 2.6 3.8 4.4 1.6 0.0 2.7 0.0 17.1 28.4 13.3 17.8 2.2 0.0 10.6 9.4 0.9 2.8 8.3 12.9 0.0 92.8 3.6 35.0 7.9 7.7 3.0 9.2 3.3 10.6 5.4 108.6 0.3 11.2 210.4 15.7 19.4 7.0 0.0 15.9 7.5 10.5 65.2 0.0 0.2 32.7 8.2 15.5 19.1 6.8 0.6 10.9 3.6 0.0 5.7 0.0 3.1 0.0 1.0 9.6 7.5 0.7 53.6 4.9 3.1 17.5 5.8 0.0 0.0 1.7 20.1 3.8 16.8 24.7 11.2 51.0 8.7 1.7 60.8 24.0 TK2 SCA31 ENSG00000166548 "Thymidine kinase 2" O00142 16 66508003-66552544 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "DNA synthesis" "Kinase, Transferase" "Disease variant, FDA approved drug targets, Primary mitochondrial disease, Progressive external ophthalmoplegia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041162 Uncertain NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 68: Epididymis - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "HPA041162: AB_10961178" "unprognostic (1.12e-1)" "unprognostic (2.11e-1)" "unprognostic (1.12e-1)" "unprognostic (6.27e-3)" "unprognostic (3.94e-1)" "unprognostic (2.93e-1)" "unprognostic (1.10e-1)" "unprognostic (4.83e-2)" "unprognostic (3.35e-2)" "unprognostic (3.45e-1)" "unprognostic (3.59e-2)" "unprognostic (2.85e-1)" "prognostic favorable (2.18e-6)" "unprognostic (3.05e-2)" "unprognostic (1.74e-1)" "unprognostic (2.71e-1)" "unprognostic (7.05e-2)" 48.1 30.2 24.2 11.8 27.6 8.5 25.6 24.7 25.7 20.0 19.7 15.0 10.9 16.2 29.3 12.3 19.0 21.1 19.2 24.1 25.6 25.1 37.3 18.7 11.7 26.5 27.8 26.8 24.4 38.0 22.4 15.1 27.6 19.2 12.7 11.7 22.6 19.9 11.5 12.7 13.5 18.9 27.5 23.0 15.7 33.9 25.8 13.0 25.6 14.6 9.9 17.8 15.4 28.3 13.3 26.5 12.1 14.5 64.3 52.2 0.7 22.0 22.3 15.1 16.8 6.5 26.4 0.1 23.8 63.9 19.0 11.8 5.3 17.7 10.4 8.5 6.2 4.1 17.2 12.9 45.1 5.6 9.2 39.4 15.3 18.5 26.1 62.5 19.9 13.1 6.8 28.1 37.9 4.1 5.5 14.9 5.9 5.1 15.4 7.0 21.0 28.1 44.1 12.5 4.4 8.9 63.2 6.1 26.9 6.6 9.6 16.3 29.7 30.8 15.9 26.3 7.6 30.3 12.2 11.6 38.9 5.7 18.4 5.6 9.4 6.0 1.8 5.1 1.2 0.1 1.3 1.0 8.7 1.7 0.6 0.9 8.5 2.7 4.3 1.8 1.2 2.5 24.2 27.6 24.7 25.7 24.1 25.6 26.5 27.8 27.6 27.5 25.8 28.3 25.0 22.4 9.3 19.6 7.3 5.7 5.1 5.8 12.5 15.5 15.4 11.4 8.0 17.2 7.5 22.0 22.9 10.0 7.6 6.0 9.8 15.7 25.2 15.2 23.2 14.4 9.6 10.3 10.1 22.4 6.0 19.9 11.7 13.0 24.8 20.6 31.1 48.9 21.7 21.9 12.0 6.5 2.0 55.6 10.1 40.5 23.3 23.6 10.6 10.3 22.6 18.4 12.3 14.6 19.4 28.9 3.3 19.2 12.4 4.3 14.4 45.9 9.0 20.5 0.0 14.4 10.6 48.9 11.1 9.6 3.8 2.9 8.6 22.2 7.6 4.2 TREX1 "AGS1, DRN3" ENSG00000213689 "Three prime repair exonuclease 1" Q9NSU2 3 48465811-48467645 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Exonuclease, Hydrolase, Nuclease" "Aicardi-Goutieres syndrome, Disease variant, Neurodegeneration, Systemic lupus erythematosus" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 53.6;Club cells: 24.5;Ionocytes: 40.7;Langerhans cells: 22.6;Melanocytes: 24.9;Respiratory ciliated cells: 29.9" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+ SV40 Large T+ RasG12V: 67.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035437, HPA046721" Supported Supported Cytosol NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Cytosol "HPA035437: AB_10672092, HPA046721: AB_2732531" 9.9 14.3 32.7 16.5 33.4 28.7 12.2 33.2 42.1 13.8 39.8 12.4 11.1 7.7 11.4 19.2 15.5 13.8 10.7 33.0 32.7 12.2 12.8 13.8 26.6 33.0 34.2 7.4 13.1 11.3 20.6 8.4 34.3 16.6 9.9 1.9 36.5 15.4 9.7 26.4 12.0 7.0 33.8 25.0 13.7 4.0 33.5 18.1 8.4 13.8 18.1 13.1 10.4 33.7 19.2 18.1 13.3 10.3 18.1 17.5 0.0 6.7 29.5 46.9 67.5 0.3 21.8 23.8 11.7 24.4 44.8 21.4 0.9 27.2 6.7 19.9 1.6 13.5 58.1 0.5 20.1 12.8 9.3 16.2 2.5 25.9 9.8 9.8 20.4 16.9 0.0 32.6 20.7 0.4 17.3 8.6 0.1 11.0 11.2 14.4 4.9 43.2 13.4 3.8 0.1 8.1 21.8 29.6 15.4 0.9 0.8 20.3 22.2 8.5 9.2 21.8 14.2 26.4 16.9 10.4 21.5 25.4 7.5 7.7 142.3 11.0 32.6 119.2 18.7 86.8 43.0 31.4 125.9 87.5 40.3 33.8 82.2 30.9 94.6 99.1 43.3 78.6 32.7 33.4 33.2 42.1 33.0 32.7 33.0 34.2 34.3 33.8 33.5 33.7 0.0 0.0 0.5 6.8 2.1 9.1 0.0 53.6 0.6 0.0 0.0 0.0 6.3 0.0 24.5 0.0 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.0 0.0 4.6 0.0 1.7 2.3 0.0 0.0 4.3 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 2.8 40.7 0.0 22.6 0.0 0.0 2.0 24.9 5.6 0.0 0.0 0.0 1.0 5.9 0.0 1.1 0.0 3.9 0.0 0.0 0.0 29.9 0.0 0.0 0.0 4.2 0.0 0.0 2.7 13.9 0.0 2.6 0.0 1.5 0.0 TREX2 ENSG00000183479 "Three prime repair exonuclease 2" Q9BQ50 X 153444720-153470587 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair" "Exonuclease, Hydrolase, Nuclease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "skin 1: 24.5" "Cell type enhanced" "Detected in single" "Suprabasal keratinocytes: 1.1" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in single" "Group enriched" "Detected in some" 11 "basophil: 1.7;eosinophil: 2.7" "Lineage enriched" "Detected in single" 14 "granulocytes: 2.7" "Cell line enhanced" "Detected in many" "HEK 293: 5.4;U-698: 7.3;U-937: 7.0" "Not detected" "Not detected" "Not detected" "Not detected" HPA054060 Uncertain NA NA "Cluster 10: Basophils - Unknown function" "Cluster 61: Skin - Cornification" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 47: Cytotrophoblasts - Unknown function" "HPA054060: AB_2682362" "unprognostic (2.32e-2)" "unprognostic (2.05e-3)" "unprognostic (1.13e-3)" "unprognostic (7.18e-4)" "unprognostic (6.05e-2)" "unprognostic (1.81e-2)" "unprognostic (8.40e-2)" "unprognostic (2.19e-1)" "unprognostic (2.09e-1)" "unprognostic (1.61e-1)" "unprognostic (1.70e-1)" "unprognostic (1.57e-1)" "unprognostic (1.42e-1)" "unprognostic (1.52e-1)" "unprognostic (9.34e-2)" "unprognostic (2.15e-1)" "unprognostic (1.23e-2)" 0.9 0.5 0.4 0.6 0.4 0.7 0.8 0.5 1.1 3.2 5.0 0.6 0.2 1.2 0.6 2.9 1.2 0.7 1.0 0.7 0.2 1.4 0.6 1.1 1.4 0.5 0.3 0.9 0.8 0.2 0.7 0.9 0.5 1.3 0.2 0.0 1.9 2.4 0.3 24.5 1.1 0.5 0.3 2.4 0.7 1.0 0.4 0.5 1.3 0.1 1.1 0.6 3.2 0.4 2.1 2.6 0.2 0.9 0.3 0.5 0.2 0.6 0.5 0.5 1.4 0.7 0.5 0.2 1.3 0.5 0.1 2.2 0.9 1.4 0.0 2.3 5.4 0.2 0.5 0.3 0.2 0.6 1.4 0.6 1.3 0.6 0.5 0.3 0.2 0.4 0.3 2.5 0.1 2.5 1.5 1.6 0.8 0.4 1.7 3.5 0.7 1.7 0.2 0.7 0.6 0.3 0.2 0.2 0.8 0.0 0.4 0.7 0.0 0.9 1.6 2.0 0.8 2.8 2.1 7.3 0.2 7.0 1.1 1.7 0.0 2.7 0.1 0.0 0.1 0.1 0.0 0.1 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.4 0.5 1.1 0.7 0.2 0.5 0.3 0.5 0.3 0.4 0.4 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 1.1 0.7 0.1 0.1 0.0 0.1 TUFM "EF-TuMT, EFTu" ENSG00000178952 "Tu translation elongation factor, mitochondrial" P49411 16 28842411-28846348 "Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, Protein biosynthesis" "Elongation factor" "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018991, HPA024087, CAB075730, CAB075731, CAB075732" Enhanced Enhanced Mitochondria NA NA 610000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 8: Non-specific - Mitochondria" "Cluster 25: RPMI-8226 - Immune response" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "CAB075730: AB_2665736, CAB075731: AB_2665737, CAB075732: AB_2665738, HPA018991: AB_1858458, HPA024087: AB_1858459" "unprognostic (1.40e-1)" "unprognostic (7.56e-2)" "unprognostic (1.29e-1)" "unprognostic (1.73e-2)" "unprognostic (2.36e-1)" "unprognostic (2.55e-2)" "unprognostic (3.39e-1)" "unprognostic (1.23e-3)" "unprognostic (8.05e-2)" "unprognostic (8.47e-2)" "unprognostic (1.80e-1)" "unprognostic (1.33e-1)" "prognostic favorable (2.69e-6)" "unprognostic (5.26e-2)" "unprognostic (1.09e-1)" "unprognostic (6.22e-2)" "unprognostic (7.36e-2)" 69.7 114.6 69.6 67.1 74.2 75.1 65.8 78.9 78.1 59.4 93.3 101.5 104.4 64.9 34.7 105.2 73.6 46.6 177.8 68.1 75.3 107.3 145.1 58.3 69.2 73.1 77.4 61.4 114.2 117.1 55.4 47.6 74.1 57.7 86.1 35.8 88.9 59.7 224.4 76.0 83.9 53.6 72.9 66.2 106.1 73.3 77.0 59.9 62.7 221.5 79.3 67.1 62.9 74.3 176.2 323.1 102.4 216.2 144.9 131.4 208.7 125.8 144.4 194.9 183.0 351.3 189.4 390.5 228.5 126.4 112.4 337.6 244.2 242.9 116.2 155.4 370.8 151.7 254.8 433.6 171.7 273.8 134.8 169.9 188.1 211.9 208.7 126.8 235.2 213.0 339.0 150.3 144.4 355.0 262.3 266.3 231.8 213.9 196.9 361.8 187.3 569.6 169.3 168.4 178.8 219.6 110.0 388.5 180.2 84.6 231.5 217.6 150.1 115.9 136.4 146.7 196.6 229.8 253.6 172.2 148.6 336.8 157.1 94.6 155.8 72.3 103.1 153.6 115.3 100.6 97.2 108.7 199.3 98.8 91.7 95.3 32.4 97.2 119.2 123.1 140.1 185.6 69.6 74.2 78.9 78.1 68.1 75.3 73.1 77.4 74.1 72.9 77.0 74.3 108.2 70.5 76.7 29.4 144.6 168.1 262.5 322.0 158.2 102.4 165.1 139.2 134.4 190.1 182.6 176.6 87.6 333.1 113.2 260.0 334.6 230.2 381.8 116.1 92.5 111.3 148.5 148.1 17.5 289.8 299.2 111.2 153.4 79.6 105.9 170.6 108.5 247.1 253.8 74.0 19.9 230.5 217.7 167.5 146.4 669.0 109.3 128.6 138.7 14.0 167.5 140.6 88.6 28.6 30.3 199.7 215.3 111.7 264.9 245.3 330.7 451.9 237.3 116.3 85.5 105.5 129.1 205.7 177.4 230.1 156.0 287.0 120.2 288.2 418.7 277.6 TUT1 "FLJ21850, FLJ22267, FLJ22347, PAPD2, RBM21, TENT1, TUTase" ENSG00000149016 "Terminal uridylyl transferase 1, U6 snRNA-specific" Q9H6E5 11 62575045-62591637 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "mRNA processing" "Nucleotidyltransferase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 32.5;Early spermatids: 34.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA069055, HPA071838" Supported Nucleoplasm,Cytosol NA NA "Cluster 10: Basophils - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 25: RPMI-8226 - Immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Nucleoplasm Cytosol "HPA069055: AB_2686075, HPA071838: AB_2686456" "unprognostic (3.81e-2)" "unprognostic (3.54e-2)" "prognostic unfavorable (9.51e-4)" "unprognostic (2.43e-1)" "unprognostic (1.01e-1)" "unprognostic (7.59e-2)" "unprognostic (1.83e-1)" "unprognostic (2.59e-2)" "unprognostic (1.83e-1)" "unprognostic (5.79e-3)" "unprognostic (1.59e-2)" "unprognostic (2.71e-1)" "unprognostic (7.20e-3)" "unprognostic (1.03e-2)" "unprognostic (4.41e-1)" "unprognostic (1.35e-1)" "unprognostic (3.97e-3)" 10.5 10.7 9.1 7.4 10.1 6.0 11.8 9.1 9.9 10.4 8.1 8.9 8.8 9.9 5.8 9.3 11.2 6.1 9.5 8.8 8.6 10.7 22.2 8.3 11.8 10.5 9.3 11.2 19.4 7.6 10.6 6.2 10.1 12.7 4.0 5.4 11.7 7.3 20.4 12.8 10.2 4.6 9.4 12.7 12.6 13.6 9.8 10.2 12.3 7.6 7.9 10.4 9.2 12.0 12.5 16.0 10.7 15.4 12.6 7.3 14.0 12.7 8.3 11.2 9.7 14.0 24.9 19.5 30.1 6.6 14.3 23.7 19.8 15.9 5.7 15.1 10.5 20.3 15.8 14.1 14.3 14.8 9.3 10.3 16.6 13.7 21.1 10.5 10.8 26.2 32.1 20.7 9.6 28.8 21.1 33.3 12.4 8.4 19.1 23.7 16.6 50.9 10.6 6.9 18.2 24.6 10.4 19.6 17.5 8.9 27.2 14.2 10.1 12.9 11.3 15.2 10.1 36.1 32.9 24.6 14.8 11.5 10.7 6.0 5.9 7.0 9.9 7.2 13.7 9.2 9.5 8.1 7.9 11.6 14.3 11.7 3.5 11.0 5.6 9.3 9.2 7.7 9.1 10.1 9.1 9.9 8.8 8.6 10.5 9.3 10.1 9.4 9.8 12.0 32.5 0.0 6.7 7.5 7.5 2.7 5.2 7.2 4.0 8.4 5.9 5.2 4.2 18.6 7.1 11.0 6.2 12.8 6.0 4.4 5.9 8.5 34.3 5.7 3.1 15.0 7.2 3.2 3.9 7.4 7.8 5.1 7.7 4.1 2.5 5.5 18.2 17.8 5.9 1.7 4.6 9.1 6.1 5.0 2.2 16.4 7.2 4.3 10.6 1.0 4.0 9.8 14.4 4.0 5.4 5.6 3.6 3.4 4.9 7.1 8.4 7.1 13.1 8.4 0.0 4.1 4.1 10.0 16.3 3.1 2.3 14.0 5.6 5.6 7.0 3.1 TUT4 "KIAA0191, PAPD3, TENT3A, ZCCHC11" ENSG00000134744 "Terminal uridylyl transferase 4" Q5TAX3 1 52408282-52553487 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "RNA-mediated gene silencing" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 52.2;Cytotrophoblasts: 53.6;dendritic cells: 64.9;Endometrial ciliated cells: 59.5;Endometrial stromal cells: 96.1;Granulosa cells: 70.7;Theca cells: 57.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027412, HPA027973" Supported Supported Nucleoli,Cytosol NA NA "Cluster 6: Non-specific - Transcription" "Cluster 77: Retina - Visual perception" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" Cytosol Nucleoli "HPA027412: AB_1852281, HPA027973: AB_10603242" "unprognostic (2.74e-2)" "unprognostic (1.67e-2)" "unprognostic (1.19e-2)" "unprognostic (3.48e-2)" "unprognostic (1.36e-2)" "unprognostic (1.85e-3)" "prognostic unfavorable (9.00e-4)" "unprognostic (2.64e-1)" "unprognostic (5.05e-2)" "unprognostic (3.84e-1)" "unprognostic (6.57e-3)" "unprognostic (3.11e-2)" "unprognostic (5.35e-3)" "unprognostic (2.26e-1)" "unprognostic (1.67e-1)" "unprognostic (7.08e-2)" "unprognostic (2.33e-1)" 22.5 34.4 28.4 18.3 28.6 26.6 21.4 44.7 36.2 34.1 28.6 26.3 8.7 27.4 23.7 19.3 30.8 15.4 27.1 26.8 35.3 22.9 31.3 22.1 34.2 28.5 29.4 46.3 31.2 29.5 41.5 21.2 28.5 26.1 11.2 84.9 20.7 16.5 60.0 35.1 30.9 15.9 26.4 35.0 22.3 46.9 33.4 32.5 31.4 30.0 29.4 23.1 26.5 33.5 24.4 22.7 55.3 37.3 21.1 27.1 36.4 20.0 31.0 30.3 34.9 23.6 12.5 50.6 23.0 30.0 49.1 19.7 41.6 22.6 38.7 39.7 36.5 53.7 30.0 49.7 35.0 59.4 29.1 31.9 49.4 32.6 40.0 38.6 21.4 35.7 44.7 25.6 25.7 0.3 60.1 42.7 39.8 12.5 27.5 51.3 55.3 39.3 33.4 20.0 28.7 26.8 31.8 14.1 32.9 62.3 19.4 31.5 18.1 23.2 30.6 21.1 26.2 52.7 74.0 71.8 15.5 32.0 17.0 83.7 9.7 34.8 26.1 4.0 19.3 49.0 27.3 21.6 5.1 50.2 33.1 22.0 37.6 25.3 3.7 61.9 23.3 5.1 28.4 28.6 44.7 36.2 26.8 35.3 28.5 29.4 28.5 26.4 33.4 33.5 52.2 0.0 0.0 0.0 36.0 0.0 0.0 0.0 0.0 0.0 36.1 41.4 0.0 0.0 0.0 47.8 0.0 53.6 64.9 0.0 15.6 28.5 0.0 59.5 96.1 14.3 0.0 0.0 0.0 17.0 19.1 18.8 0.0 46.7 0.0 70.7 0.0 0.0 16.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.8 0.0 0.0 9.8 0.0 0.0 0.0 0.0 19.6 0.0 0.0 30.2 0.0 0.0 22.0 0.0 0.0 0.0 0.0 23.8 0.0 0.0 0.0 0.0 36.9 28.2 57.3 0.0 0.0 TUT7 "FLJ13409, KIAA1711, PAPD6, TENT3B, ZCCHC6" ENSG00000083223 "Terminal uridylyl transferase 7" Q5VYS8 9 86287733-86354454 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 80.3;Endometrial stromal cells: 61.1;Glandular and luminal cells: 206.7;Syncytiotrophoblasts: 92.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 114.6" "Group enriched" "Detected in all" 5 "granulocytes: 114.6;monocytes: 47.8" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020615, HPA020620" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 85: Liver - Metabolism" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Cytosol Nucleoplasm "HPA020615: AB_1858983, HPA020620: AB_1858984" "unprognostic (1.10e-1)" "unprognostic (1.36e-1)" "unprognostic (1.64e-1)" "unprognostic (1.26e-2)" "unprognostic (3.66e-1)" "unprognostic (1.39e-1)" "unprognostic (4.11e-2)" "unprognostic (2.49e-2)" "unprognostic (4.43e-2)" "unprognostic (6.51e-2)" "unprognostic (1.91e-2)" "unprognostic (3.07e-1)" "unprognostic (5.79e-3)" "unprognostic (1.59e-2)" "unprognostic (1.13e-1)" "unprognostic (4.14e-2)" "unprognostic (1.40e-1)" 12.5 9.4 4.8 16.0 6.4 22.6 18.7 5.9 10.0 12.8 10.9 12.1 11.0 9.1 8.9 24.7 8.8 11.3 8.2 5.1 7.9 7.5 38.4 16.5 19.1 9.0 6.3 8.7 13.1 8.7 8.2 14.3 7.8 20.8 11.8 7.7 14.2 7.2 13.6 33.7 12.3 7.8 5.1 20.6 13.6 11.6 9.2 15.1 8.6 9.3 19.2 13.4 16.0 9.0 16.2 17.2 9.8 14.3 22.4 36.0 12.2 21.6 20.5 9.1 10.6 7.8 13.7 22.8 18.9 14.0 9.5 27.3 11.8 12.0 13.5 27.1 6.0 16.5 18.4 13.7 19.3 19.1 21.8 23.5 22.7 14.5 16.2 13.7 15.0 12.3 15.9 24.0 24.6 14.9 16.0 11.0 7.5 25.1 11.1 8.0 17.5 10.1 15.3 31.4 7.2 5.7 13.1 15.5 7.4 11.6 6.4 7.8 24.8 8.7 10.5 15.7 14.8 27.4 23.3 16.5 20.7 10.8 11.8 35.4 19.4 20.5 15.0 24.7 12.5 11.6 8.2 10.7 11.9 12.2 9.5 10.1 114.6 12.8 47.8 5.5 8.8 8.9 4.8 6.4 5.9 10.0 5.1 7.9 9.0 6.3 7.8 5.1 9.2 9.0 28.1 0.0 0.0 0.0 14.5 0.0 0.0 0.0 0.0 0.0 34.2 16.4 0.0 0.0 0.0 9.2 0.0 22.4 36.6 0.0 5.9 29.6 0.0 80.3 61.1 7.2 0.0 0.0 0.0 17.9 17.4 5.6 0.0 206.7 0.0 36.0 0.0 0.0 22.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 26.1 0.0 0.0 12.4 0.0 0.0 0.0 0.0 27.8 0.0 0.0 13.8 0.0 0.0 6.7 0.0 0.0 0.0 0.0 9.1 0.0 0.0 0.0 0.0 92.5 14.8 30.9 0.0 0.0 TXNRD1 "GRIM-12, Trxr1, TXNR" ENSG00000198431 "Thioredoxin reductase 1" Q16881 12 104215779-104350307 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Electron transport, Transport" Oxidoreductase "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 459.7;Prostatic glandular cells: 557.4;Urothelial cells: 488.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "fHDF/TERT166: 1452.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001395, CAB004607, CAB015834, HPA043871" Approved Supported Nucleoplasm NA NA 6100000 "Cluster 46: Basophils - DNA binding" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 22: Epithelial cell types - Mixed function" Nucleoplasm "CAB004607: AB_628405, CAB015834: , HPA001395: AB_1858377, HPA043871: AB_2678709" "unprognostic (2.52e-2)" "unprognostic (1.16e-1)" "unprognostic (5.48e-2)" "unprognostic (1.01e-1)" "unprognostic (3.15e-1)" "unprognostic (1.94e-2)" "prognostic unfavorable (1.12e-5)" "unprognostic (5.55e-2)" "unprognostic (1.18e-1)" "unprognostic (1.08e-1)" "unprognostic (6.42e-2)" "unprognostic (2.21e-1)" "prognostic unfavorable (1.20e-5)" "unprognostic (2.13e-1)" "unprognostic (1.27e-1)" "unprognostic (1.18e-2)" "unprognostic (8.80e-2)" 47.1 148.1 22.5 40.6 21.1 64.7 28.0 20.9 22.6 28.0 37.3 50.9 58.4 47.9 21.0 30.7 39.0 55.9 65.8 21.1 29.8 37.9 46.5 63.0 34.4 55.2 26.7 34.1 19.0 33.8 21.2 39.1 33.3 41.0 45.6 20.1 20.8 60.6 67.8 12.4 39.4 51.6 22.9 27.8 52.1 37.8 24.6 42.8 30.4 64.0 34.1 141.6 30.1 25.7 228.4 1032.6 118.1 111.3 553.5 308.0 409.8 412.4 259.3 182.7 186.8 110.5 329.4 169.3 187.0 1452.6 682.1 77.7 235.7 158.6 214.1 82.7 101.8 143.1 765.8 468.0 885.7 226.3 149.9 176.9 159.8 403.7 128.1 557.1 634.0 227.9 200.5 77.5 276.8 109.1 233.4 102.7 114.4 453.0 1053.1 227.3 82.1 146.5 211.2 123.1 182.6 110.6 333.3 519.1 325.2 222.6 123.2 131.4 854.5 89.3 183.7 201.3 341.2 84.8 179.9 254.5 186.8 122.5 538.0 109.4 29.9 69.7 23.6 39.0 26.9 21.3 21.6 23.9 39.5 14.5 19.1 16.7 102.6 24.4 48.4 25.2 19.8 27.6 22.5 21.1 20.9 22.6 21.1 29.8 55.2 26.7 33.3 22.9 24.6 25.7 26.0 64.1 67.5 50.3 27.6 104.0 459.7 41.3 40.9 28.1 19.4 16.3 66.2 32.9 79.3 16.5 22.9 26.1 40.4 93.4 41.1 79.6 45.0 100.9 36.8 116.2 20.4 46.3 48.2 80.7 34.3 90.1 69.8 119.6 53.2 35.2 49.2 68.2 42.0 28.6 56.7 18.8 44.7 43.5 100.5 19.1 68.0 62.2 19.6 49.6 51.9 24.8 26.8 29.1 55.3 197.7 40.5 29.3 28.4 557.4 24.6 37.5 105.5 20.9 0.0 43.4 84.0 14.4 33.8 24.3 72.9 51.3 28.5 98.4 33.0 488.0 TXNRD2 "SELZ, TR, TR3, TRXR2" ENSG00000184470 "Thioredoxin reductase 2" Q9NNW7 22 19875517-19941820 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-2 OS: 139.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002007, HPA003323" Supported Approved Mitochondria,Cytosol NA NA 2800000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 18: Non-specific - Mitochondria" "Cluster 1: K-562 - Erythropoiesis" "Cluster 47: Cytotrophoblasts - Unknown function" "Mitochondria, Cytosol" "CAB002007: , HPA003323: AB_1080396" "unprognostic (3.17e-2)" "unprognostic (8.72e-2)" "unprognostic (4.30e-1)" "unprognostic (9.71e-3)" "unprognostic (7.25e-2)" "unprognostic (6.35e-2)" "unprognostic (3.21e-1)" "unprognostic (1.12e-1)" "unprognostic (2.78e-1)" "unprognostic (2.83e-1)" "unprognostic (4.94e-3)" "unprognostic (2.49e-1)" "prognostic favorable (1.10e-7)" "unprognostic (2.47e-1)" "unprognostic (5.99e-2)" "unprognostic (1.69e-1)" "unprognostic (1.10e-1)" 10.5 44.4 11.9 8.9 12.0 14.5 12.3 18.1 19.3 11.7 21.2 14.9 10.3 10.6 6.2 10.2 10.6 6.2 30.0 12.9 11.9 24.8 65.4 13.6 9.1 11.8 12.1 16.5 15.9 13.5 14.4 9.8 11.5 26.8 4.6 4.4 15.4 8.2 23.0 10.9 12.0 5.1 11.3 16.9 26.4 14.6 12.4 4.9 15.2 16.1 6.1 11.8 10.4 11.8 19.4 39.2 3.5 14.9 6.9 9.6 8.8 18.8 21.1 31.8 23.4 36.7 19.4 10.9 43.2 19.0 32.7 33.2 17.8 25.2 12.1 21.6 46.5 18.8 34.4 22.4 12.9 21.1 8.4 9.2 18.5 16.2 13.8 12.9 91.3 2.2 106.4 17.4 24.8 47.1 7.2 30.1 17.7 46.9 27.6 10.5 85.2 10.0 19.3 21.0 19.1 16.4 32.0 39.9 21.8 5.8 33.7 27.6 52.2 23.0 139.5 19.8 38.4 17.6 14.0 6.9 22.4 15.5 30.3 2.7 10.5 5.8 3.5 8.2 2.6 3.9 3.0 3.2 7.8 2.6 3.9 3.2 0.9 3.8 7.9 2.9 2.1 4.6 11.9 12.0 18.1 19.3 12.9 11.9 11.8 12.1 11.5 11.3 12.4 11.8 5.6 16.0 23.6 11.1 10.3 4.2 23.1 15.1 3.4 22.1 11.4 9.1 16.7 15.7 15.7 20.2 10.4 60.7 8.8 14.7 58.7 22.0 26.4 9.8 8.4 14.4 1.2 33.1 9.2 32.0 24.3 12.4 23.4 10.0 1.3 27.6 8.9 49.5 25.9 10.1 8.5 16.9 20.3 22.0 7.8 18.2 15.5 14.6 5.4 10.3 27.2 18.7 10.3 8.5 7.2 22.3 13.9 9.1 12.2 17.8 15.6 52.0 16.6 11.0 6.6 11.3 13.3 10.9 14.0 6.4 5.3 42.0 11.4 36.4 16.4 15.7 TXNRD3 "TGR, TR2, TR2IT1, TRXR3, TXNRD3IT1, TXNRD3NB, TXNRD3NT1" ENSG00000197763 "Thioredoxin reductase 3" Q86VQ6 3 126571779-126655124 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Differentiation, Electron transport, Spermatogenesis, Transport" "Developmental protein, Oxidoreductase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 20.4" "Cell type enhanced" "Detected in many" "Spermatocytes: 71.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "naive CD4 T-cell: 1.0" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB020802, HPA036109" Uncertain Enhanced Nucleoplasm,Cytosol NA NA "Cluster 32: T-cells - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 30: Epithelial cell lines - Translation" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Nucleoplasm Cytosol "CAB020802: , HPA036109: AB_2674945" "unprognostic (1.41e-1)" "unprognostic (1.55e-2)" "unprognostic (3.92e-1)" "prognostic unfavorable (3.35e-4)" "unprognostic (3.90e-1)" "unprognostic (2.96e-1)" "unprognostic (3.01e-1)" "unprognostic (3.39e-2)" "unprognostic (1.07e-1)" "unprognostic (1.03e-1)" "prognostic unfavorable (2.86e-4)" "unprognostic (3.14e-1)" "prognostic favorable (2.72e-4)" "unprognostic (5.94e-2)" "unprognostic (1.74e-1)" "unprognostic (1.03e-2)" "unprognostic (2.51e-1)" 4.9 4.0 2.4 2.2 2.4 1.1 6.1 3.4 1.9 4.7 3.1 2.4 1.3 5.1 5.9 4.8 3.6 3.6 3.1 1.8 3.3 5.7 8.7 4.2 1.1 2.8 3.0 6.7 6.3 8.2 1.7 2.9 2.8 3.8 3.0 1.9 3.7 4.1 5.6 3.2 1.4 4.9 3.0 2.6 3.6 20.4 3.0 4.6 6.1 5.8 1.4 3.2 1.9 2.8 16.0 3.8 4.9 8.3 8.7 13.1 2.7 6.7 5.8 5.4 7.4 7.6 8.7 0.0 8.5 9.7 3.4 6.4 6.3 7.1 6.4 0.0 5.1 1.5 3.7 5.9 7.8 6.4 0.6 13.1 5.9 1.8 12.1 7.0 3.8 5.2 3.7 0.0 9.0 12.2 1.4 3.4 7.3 4.3 3.4 0.5 4.2 2.6 6.0 8.0 8.9 5.1 19.9 5.7 10.3 3.7 8.0 2.6 6.9 6.8 1.8 9.3 3.3 4.0 1.9 0.0 3.5 2.2 5.6 0.0 0.2 0.1 0.1 0.2 0.0 0.0 0.0 0.1 0.2 0.0 1.0 0.3 0.0 0.2 0.0 0.0 0.0 0.1 2.4 2.4 3.4 1.9 1.8 3.3 2.8 3.0 2.8 3.0 3.0 2.8 1.3 3.2 7.2 14.4 0.4 1.0 5.7 1.6 6.2 2.0 2.9 2.4 4.1 4.3 3.0 3.7 2.1 9.4 0.1 0.5 3.9 5.1 18.2 1.5 4.0 1.7 4.2 3.0 7.5 3.8 5.4 5.3 4.1 1.0 5.7 6.1 2.9 8.0 2.9 0.0 5.8 2.4 0.0 0.8 0.7 4.0 4.7 1.0 0.0 3.7 0.0 3.2 0.0 11.1 4.7 3.8 0.3 8.6 0.1 5.5 0.1 4.5 3.3 0.9 0.0 5.7 2.8 71.5 18.2 6.1 0.6 7.3 0.6 6.6 1.5 3.2 UCK1 "FLJ12255, URK1" ENSG00000130717 "Uridine-cytidine kinase 1" Q9HA47 9 131523801-131531264 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA050969, HPA070526" Approved Approved Nucleoplasm,Nucleoli NA NA "Cluster 35: T-regs - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm Nucleoli "HPA050969: AB_2681294, HPA070526: " "unprognostic (2.20e-1)" "prognostic favorable (3.19e-4)" "unprognostic (1.16e-2)" "unprognostic (1.74e-3)" "unprognostic (7.29e-2)" "unprognostic (1.43e-1)" "unprognostic (8.71e-2)" "unprognostic (1.78e-1)" "unprognostic (2.44e-1)" "unprognostic (1.18e-1)" "unprognostic (1.36e-3)" "unprognostic (1.54e-1)" "prognostic favorable (2.21e-7)" "unprognostic (5.11e-2)" "unprognostic (3.29e-2)" "unprognostic (1.74e-1)" "unprognostic (1.07e-1)" 21.5 25.3 40.3 10.2 41.2 16.4 20.4 40.5 45.2 21.2 37.0 26.0 11.8 20.2 18.7 21.2 19.9 12.2 28.1 38.1 39.2 29.3 52.7 17.2 15.1 41.6 41.4 22.2 29.8 22.6 24.2 14.3 40.0 26.9 9.3 13.5 25.6 17.3 43.9 19.1 18.0 11.2 40.7 20.9 24.9 20.4 42.1 17.5 23.4 26.8 11.5 20.9 17.2 40.9 13.9 30.0 33.9 43.8 23.6 16.7 28.9 22.0 32.1 37.0 28.0 30.1 12.4 15.0 12.9 26.4 28.9 26.3 31.9 28.0 15.8 27.7 29.8 14.0 46.3 19.2 33.6 23.2 19.9 18.8 25.8 29.9 21.6 22.4 23.0 36.3 17.9 11.2 27.6 55.2 31.9 11.8 40.4 27.0 29.6 30.1 52.5 25.1 24.1 13.0 45.7 28.9 31.8 23.9 34.3 15.4 46.6 13.5 17.1 40.9 20.7 25.7 21.7 22.7 31.3 19.4 20.3 16.0 29.1 2.1 5.5 9.0 7.3 7.2 9.8 7.4 8.5 6.4 5.2 8.0 11.3 5.6 3.6 7.0 2.6 5.9 12.0 5.6 40.3 41.2 40.5 45.2 38.1 39.2 41.6 41.4 40.0 40.7 42.1 40.9 13.6 16.0 5.0 7.8 12.4 14.3 10.3 9.9 12.5 18.0 16.2 20.1 14.0 4.3 6.2 14.7 8.4 33.8 12.0 20.4 29.4 22.7 21.9 9.0 10.2 14.3 12.1 3.0 4.7 26.2 17.5 15.7 6.6 9.2 2.5 16.2 13.2 20.5 26.4 26.9 6.1 11.6 16.2 10.0 13.4 33.3 17.7 14.0 16.0 4.7 20.4 22.0 9.2 2.0 6.0 18.6 12.3 19.9 8.0 14.3 21.1 31.6 3.1 13.1 19.7 12.4 17.2 32.8 33.4 11.8 12.5 25.7 10.0 14.9 14.8 8.5 UCK2 UMPK ENSG00000143179 "Uridine-cytidine kinase 2" Q9BZX2 1 165827614-165911618 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 110.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA057128 Approved Nucleoplasm NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 23: Spermatids - Flagellum & Golgi organization" Nucleoplasm "HPA057128: AB_2683346" "unprognostic (5.37e-2)" "unprognostic (1.75e-2)" "unprognostic (2.51e-1)" "unprognostic (1.20e-2)" "unprognostic (4.54e-2)" "unprognostic (6.83e-3)" "prognostic unfavorable (9.22e-8)" "prognostic unfavorable (4.98e-4)" "prognostic unfavorable (6.70e-4)" "unprognostic (3.04e-2)" "unprognostic (1.49e-1)" "unprognostic (1.13e-2)" "prognostic unfavorable (5.12e-13)" "unprognostic (2.49e-3)" "unprognostic (1.14e-1)" "unprognostic (2.01e-3)" "unprognostic (1.83e-1)" 12.8 6.0 5.9 9.2 6.0 11.8 15.3 8.9 7.7 8.3 2.5 14.5 13.9 8.0 15.2 17.4 7.5 5.0 9.2 7.2 7.1 7.0 10.6 9.9 8.5 8.0 8.9 5.5 16.0 4.8 7.4 28.0 9.9 6.8 14.1 3.7 13.1 8.4 17.0 13.9 13.2 8.5 5.7 5.9 11.2 6.0 6.2 17.7 5.2 10.8 10.6 14.2 9.9 6.0 66.1 67.7 36.6 34.4 20.2 32.9 49.3 63.4 59.7 86.7 92.2 70.6 75.3 32.3 43.5 57.6 35.2 46.3 88.6 106.2 72.3 51.3 40.8 40.2 52.3 81.8 56.2 72.1 29.2 35.0 52.1 176.6 111.7 21.5 60.8 73.6 95.3 43.0 78.1 54.1 63.6 49.4 103.4 104.7 54.5 27.8 37.6 112.5 43.5 37.6 51.5 58.3 47.2 104.4 48.8 83.3 62.5 65.9 32.9 41.4 52.1 50.3 71.9 49.8 84.9 116.0 36.7 50.1 33.3 0.8 5.9 0.1 1.5 3.7 3.6 3.3 1.6 2.5 15.1 4.4 0.1 1.4 0.1 3.8 4.2 13.9 2.2 1.9 5.9 6.0 8.9 7.7 7.2 7.1 8.0 8.9 9.9 5.7 6.2 6.0 10.2 0.0 1.1 10.7 6.6 22.9 29.6 18.3 19.9 4.2 22.4 26.2 5.7 8.6 8.8 9.2 0.0 4.4 12.9 41.5 7.9 14.7 110.4 8.7 12.1 22.3 6.7 10.7 32.8 22.2 60.1 12.4 17.3 11.4 0.0 15.4 5.0 5.8 13.0 0.0 33.1 16.1 14.2 4.1 10.2 56.2 6.5 7.9 10.6 30.0 13.5 4.5 9.2 19.6 23.3 54.8 16.1 3.4 25.8 33.0 31.4 6.7 4.5 4.6 0.0 23.0 15.3 5.6 12.0 26.9 29.7 26.4 4.1 5.4 20.4 22.3 UCKL1 "FLJ20517, URKL1" ENSG00000198276 "Uridine-cytidine kinase 1 like 1" Q9NWZ5 20 63939829-63956416 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Rod photoreceptor cells: 148.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004722, HPA004769" Approved Approved "Endoplasmic reticulum" NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 72: Non-specific - Transcription" "Cluster 39: CACO-2 - Unknown function" "Cluster 46: Photoreceptor cells - Phototransduction" "Endoplasmic reticulum" "HPA004722: AB_1080455, HPA004769: AB_1080453" "unprognostic (1.03e-1)" "unprognostic (2.77e-2)" "unprognostic (2.64e-1)" "unprognostic (8.34e-2)" "unprognostic (7.29e-2)" "unprognostic (1.20e-1)" "unprognostic (1.99e-2)" "unprognostic (1.87e-1)" "unprognostic (2.45e-1)" "unprognostic (1.29e-1)" "prognostic favorable (4.42e-4)" "unprognostic (5.87e-2)" "unprognostic (3.18e-2)" "unprognostic (9.11e-2)" "unprognostic (2.81e-1)" "unprognostic (3.01e-1)" "unprognostic (5.26e-3)" 41.9 47.3 21.2 17.4 23.2 24.7 44.0 32.0 33.2 53.7 24.4 46.9 33.5 41.9 7.2 50.4 49.8 11.9 57.1 20.4 21.2 55.1 55.6 40.6 21.2 23.9 21.5 74.9 46.3 17.2 52.3 17.9 23.7 49.4 8.7 55.9 43.4 17.6 61.1 43.0 51.8 9.6 19.4 64.7 37.2 25.7 22.7 15.9 59.0 36.6 11.0 40.1 54.0 31.4 29.2 30.3 25.5 34.2 18.4 15.6 40.9 22.8 15.4 46.2 23.0 72.8 22.0 29.3 37.5 14.9 31.6 46.7 20.0 31.4 9.2 12.3 33.6 22.2 67.8 108.1 20.3 38.2 40.8 21.9 27.6 18.5 15.1 18.3 21.5 28.4 32.1 30.3 14.6 37.4 45.1 66.3 18.9 23.0 70.0 45.4 19.2 51.0 19.1 41.4 60.3 35.3 32.9 31.8 36.2 12.7 33.4 34.1 24.2 48.7 18.2 32.1 30.1 31.5 18.1 13.6 25.0 27.1 18.8 8.0 11.4 9.9 18.3 19.7 21.0 31.0 17.8 15.8 13.3 17.1 10.1 12.4 1.8 8.5 22.2 7.6 20.8 12.1 21.2 23.2 32.0 33.2 20.4 21.2 23.9 21.5 23.7 19.4 22.7 31.4 31.7 25.6 8.3 17.0 24.1 18.9 21.4 29.9 14.8 30.7 13.5 17.3 20.3 18.6 17.7 9.2 83.4 31.2 16.8 24.7 23.5 19.4 2.4 18.2 17.0 19.4 21.5 5.5 7.8 11.1 23.6 17.5 25.0 22.7 13.3 21.1 13.6 12.4 17.6 20.2 9.7 21.2 32.6 11.4 16.4 3.7 17.7 14.5 10.6 4.7 17.0 18.5 12.3 10.1 12.2 17.5 27.4 20.7 21.4 17.8 38.7 16.1 11.3 148.0 26.3 16.2 30.1 12.7 12.4 22.5 19.0 33.4 22.0 28.4 24.3 19.2 UPP1 "UDRPASE, UP, UPASE, UPP" ENSG00000183696 "Uridine phosphorylase 1" Q16831 7 48088628-48108736 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 66.9" "Cell type enhanced" "Detected in many" "Distal enterocytes: 250.1;Extravillous trophoblasts: 260.3;Macrophages: 199.5;Paneth cells: 260.8" "Cancer enhanced" "Detected in all" "testis cancer: 62.8" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in many" 4 "hTERT-HME1: 362.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA054040, HPA055394" Enhanced Enhanced Nucleoplasm No No "Cluster 7: Monocytes - Unknown function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "HPA054040: AB_2682352, HPA055394: AB_2682805" "unprognostic (1.16e-1)" "prognostic unfavorable (1.02e-4)" "unprognostic (5.96e-2)" "unprognostic (1.01e-1)" "unprognostic (3.21e-3)" "unprognostic (6.36e-2)" "unprognostic (1.78e-3)" "prognostic unfavorable (1.97e-4)" "unprognostic (3.81e-2)" "unprognostic (1.91e-1)" "unprognostic (1.53e-1)" "unprognostic (2.59e-1)" "unprognostic (1.52e-3)" "unprognostic (2.95e-2)" "unprognostic (1.30e-1)" "unprognostic (1.30e-1)" "unprognostic (1.39e-1)" 16.4 9.4 3.8 7.5 4.4 12.5 10.0 3.0 5.8 16.8 2.0 9.8 4.3 3.9 0.8 66.9 5.7 5.9 8.9 3.1 3.9 39.8 11.9 18.8 3.7 4.2 2.8 1.9 4.6 5.0 7.4 3.8 3.7 4.9 5.3 0.5 14.2 1.1 3.7 3.1 6.5 3.4 1.3 20.3 4.1 2.2 4.4 1.2 8.0 0.9 6.6 9.1 31.2 3.7 19.5 26.0 2.4 5.2 8.9 4.0 29.7 7.9 15.5 14.5 17.5 10.8 9.9 0.0 2.5 9.7 89.9 13.9 5.2 46.1 9.4 4.1 4.5 0.8 4.8 4.6 7.4 0.9 1.3 5.0 21.8 6.4 362.8 5.9 9.1 0.4 1.5 13.5 7.6 2.3 0.0 2.9 9.4 4.2 20.7 0.0 4.8 6.0 33.7 11.5 2.3 1.6 10.2 3.0 63.4 29.3 2.4 0.9 12.4 29.6 22.9 7.3 22.6 21.4 34.7 3.7 29.6 3.0 77.8 11.5 16.0 12.2 11.8 12.1 8.9 0.2 7.8 8.7 6.5 0.6 8.1 8.1 6.2 5.4 14.8 0.5 8.4 10.9 3.8 4.4 3.0 5.8 3.1 3.9 4.2 2.8 3.7 1.3 4.4 3.7 107.4 19.2 58.5 5.2 19.1 46.8 26.3 104.4 19.4 27.6 9.0 16.1 11.6 24.3 51.0 11.0 33.3 15.1 122.9 250.1 70.5 50.5 1.0 42.1 22.4 108.1 13.1 4.4 16.5 40.5 260.3 34.1 5.1 91.1 25.9 3.8 72.5 17.5 110.0 16.8 29.4 35.0 85.5 130.5 118.1 2.4 5.3 199.5 87.2 1.0 61.4 13.3 71.1 4.0 3.6 117.9 260.8 2.2 30.3 30.4 42.8 23.3 11.9 29.2 6.6 21.1 32.2 0.3 9.5 42.9 29.8 78.7 71.0 1.5 29.1 34.9 UPP2 "UDRPASE2, UP2, UPASE2" ENSG00000007001 "Uridine phosphorylase 2" O95045 2 157876702-158136154 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 9 "kidney: 45.8;liver: 23.9" "Cell type enhanced" "Detected in some" "Astrocytes: 24.2;Distal tubular cells: 13.7;Excitatory neurons: 32.5;Inhibitory neurons: 20.8;Oligodendrocyte precursor cells: 27.6;Proximal tubular cells: 82.1" "Cancer enriched" "Detected in some" 6 "liver cancer: 3.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA035225, HPA035226" Approved Nucleoplasm,Vesicles,Mitochondria NA NA "Cluster 81: Kidney & Liver - Metabolism" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "Vesicles, Mitochondria" "HPA035225: AB_10604002, HPA035226: AB_10696503" "unprognostic (1.87e-1)" "unprognostic (2.33e-1)" "unprognostic (4.22e-3)" "unprognostic (1.36e-3)" "unprognostic (2.29e-1)" "unprognostic (1.55e-1)" "unprognostic (3.53e-2)" "unprognostic (5.51e-2)" "unprognostic (5.11e-2)" "unprognostic (1.23e-2)" "unprognostic (4.65e-3)" "unprognostic (2.34e-1)" "unprognostic (2.23e-2)" "unprognostic (4.89e-2)" "unprognostic (2.78e-2)" "unprognostic (1.78e-2)" "unprognostic (1.16e-2)" 0.0 0.1 3.3 0.0 2.9 0.0 0.0 1.8 3.0 0.1 1.4 0.0 0.0 0.0 0.3 0.0 0.1 0.1 0.0 3.7 1.9 45.8 23.9 0.0 0.1 1.3 1.3 0.3 0.1 0.0 0.2 0.0 1.1 0.0 0.0 0.9 0.4 0.0 0.0 0.3 0.1 0.0 1.4 0.0 0.0 0.1 1.6 0.0 0.2 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.1 0.2 0.2 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 2.9 1.8 3.0 3.7 1.9 1.3 1.3 1.1 1.4 1.6 2.4 0.0 0.0 0.0 24.2 0.2 0.0 0.1 0.0 0.0 1.3 0.1 0.3 0.1 0.0 0.0 1.8 0.0 0.0 0.0 0.0 13.7 0.0 0.1 0.2 0.1 0.1 0.0 0.0 32.5 0.0 0.0 0.0 0.0 0.1 0.0 0.1 1.1 8.2 0.0 0.0 20.8 0.0 0.0 0.9 0.0 0.1 0.3 0.5 0.0 2.8 0.0 0.1 0.0 27.6 3.3 0.0 0.0 0.0 0.0 0.0 0.0 82.1 0.0 1.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1