Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific nTPM" "RNA single cell type specificity" "RNA single cell type distribution" "RNA single cell type specificity score" "RNA single cell type specific nTPM" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific nTPM" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific nTPM" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific nTPM" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific nTPM" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific nTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific nTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "CCD Protein" "CCD Transcript" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Blood expression cluster" "Tissue expression cluster" "Cell line expression cluster" "Single cell expression cluster" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [nTPM]" "Tissue RNA - adrenal gland [nTPM]" "Tissue RNA - amygdala [nTPM]" "Tissue RNA - appendix [nTPM]" "Tissue RNA - basal ganglia [nTPM]" "Tissue RNA - bone marrow [nTPM]" "Tissue RNA - breast [nTPM]" "Tissue RNA - cerebellum [nTPM]" "Tissue RNA - cerebral cortex [nTPM]" "Tissue RNA - cervix [nTPM]" "Tissue RNA - choroid plexus [nTPM]" "Tissue RNA - colon [nTPM]" "Tissue RNA - duodenum [nTPM]" "Tissue RNA - endometrium 1 [nTPM]" "Tissue RNA - epididymis [nTPM]" "Tissue RNA - esophagus [nTPM]" "Tissue RNA - fallopian tube [nTPM]" "Tissue RNA - gallbladder [nTPM]" "Tissue RNA - heart muscle [nTPM]" "Tissue RNA - hippocampal formation [nTPM]" "Tissue RNA - hypothalamus [nTPM]" "Tissue RNA - kidney [nTPM]" "Tissue RNA - liver [nTPM]" "Tissue RNA - lung [nTPM]" "Tissue RNA - lymph node [nTPM]" "Tissue RNA - medulla oblongata [nTPM]" "Tissue RNA - midbrain [nTPM]" "Tissue RNA - ovary [nTPM]" "Tissue RNA - pancreas [nTPM]" "Tissue RNA - parathyroid gland [nTPM]" "Tissue RNA - pituitary gland [nTPM]" "Tissue RNA - placenta [nTPM]" "Tissue RNA - pons [nTPM]" "Tissue RNA - prostate [nTPM]" "Tissue RNA - rectum [nTPM]" "Tissue RNA - retina [nTPM]" "Tissue RNA - salivary gland [nTPM]" "Tissue RNA - seminal vesicle [nTPM]" "Tissue RNA - skeletal muscle [nTPM]" "Tissue RNA - skin 1 [nTPM]" "Tissue RNA - small intestine [nTPM]" "Tissue RNA - smooth muscle [nTPM]" "Tissue RNA - spinal cord [nTPM]" "Tissue RNA - spleen [nTPM]" "Tissue RNA - stomach 1 [nTPM]" "Tissue RNA - testis [nTPM]" "Tissue RNA - thalamus [nTPM]" "Tissue RNA - thymus [nTPM]" "Tissue RNA - thyroid gland [nTPM]" "Tissue RNA - tongue [nTPM]" "Tissue RNA - tonsil [nTPM]" "Tissue RNA - urinary bladder [nTPM]" "Tissue RNA - vagina [nTPM]" "Tissue RNA - white matter [nTPM]" "Cell RNA - A-431 [nTPM]" "Cell RNA - A549 [nTPM]" "Cell RNA - AF22 [nTPM]" "Cell RNA - AN3-CA [nTPM]" "Cell RNA - ASC diff [nTPM]" "Cell RNA - ASC TERT1 [nTPM]" "Cell RNA - BEWO [nTPM]" "Cell RNA - BJ [nTPM]" "Cell RNA - BJ hTERT+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]" "Cell RNA - CACO-2 [nTPM]" "Cell RNA - CAPAN-2 [nTPM]" "Cell RNA - Daudi [nTPM]" "Cell RNA - EFO-21 [nTPM]" "Cell RNA - fHDF/TERT166 [nTPM]" "Cell RNA - GAMG [nTPM]" "Cell RNA - HaCaT [nTPM]" "Cell RNA - HAP1 [nTPM]" "Cell RNA - HBEC3-KT [nTPM]" "Cell RNA - HBF TERT88 [nTPM]" "Cell RNA - HDLM-2 [nTPM]" "Cell RNA - HEK 293 [nTPM]" "Cell RNA - HEL [nTPM]" "Cell RNA - HeLa [nTPM]" "Cell RNA - Hep G2 [nTPM]" "Cell RNA - HHSteC [nTPM]" "Cell RNA - HL-60 [nTPM]" "Cell RNA - HMC-1 [nTPM]" "Cell RNA - HSkMC [nTPM]" "Cell RNA - hTCEpi [nTPM]" "Cell RNA - hTEC/SVTERT24-B [nTPM]" "Cell RNA - hTERT-HME1 [nTPM]" "Cell RNA - hTERT-RPE1 [nTPM]" "Cell RNA - HUVEC TERT2 [nTPM]" "Cell RNA - JURKAT [nTPM]" "Cell RNA - K-562 [nTPM]" "Cell RNA - Karpas-707 [nTPM]" "Cell RNA - LHCN-M2 [nTPM]" "Cell RNA - MCF7 [nTPM]" "Cell RNA - MOLT-4 [nTPM]" "Cell RNA - NB-4 [nTPM]" "Cell RNA - NTERA-2 [nTPM]" "Cell RNA - OE19 [nTPM]" "Cell RNA - PC-3 [nTPM]" "Cell RNA - REH [nTPM]" "Cell RNA - RH-30 [nTPM]" "Cell RNA - RPMI-8226 [nTPM]" "Cell RNA - RPTEC TERT1 [nTPM]" "Cell RNA - RT4 [nTPM]" "Cell RNA - SCLC-21H [nTPM]" "Cell RNA - SH-SY5Y [nTPM]" "Cell RNA - SiHa [nTPM]" "Cell RNA - SK-BR-3 [nTPM]" "Cell RNA - SK-MEL-30 [nTPM]" "Cell RNA - SuSa [nTPM]" "Cell RNA - T-47d [nTPM]" "Cell RNA - THP-1 [nTPM]" "Cell RNA - TIME [nTPM]" "Cell RNA - U-138 MG [nTPM]" "Cell RNA - U-2 OS [nTPM]" "Cell RNA - U-2197 [nTPM]" "Cell RNA - U-251 MG [nTPM]" "Cell RNA - U-266/70 [nTPM]" "Cell RNA - U-266/84 [nTPM]" "Cell RNA - U-698 [nTPM]" "Cell RNA - U-87 MG [nTPM]" "Cell RNA - U-937 [nTPM]" "Cell RNA - WM-115 [nTPM]" "Blood RNA - basophil [nTPM]" "Blood RNA - classical monocyte [nTPM]" "Blood RNA - eosinophil [nTPM]" "Blood RNA - gdT-cell [nTPM]" "Blood RNA - intermediate monocyte [nTPM]" "Blood RNA - MAIT T-cell [nTPM]" "Blood RNA - memory B-cell [nTPM]" "Blood RNA - memory CD4 T-cell [nTPM]" "Blood RNA - memory CD8 T-cell [nTPM]" "Blood RNA - myeloid DC [nTPM]" "Blood RNA - naive B-cell [nTPM]" "Blood RNA - naive CD4 T-cell [nTPM]" "Blood RNA - naive CD8 T-cell [nTPM]" "Blood RNA - neutrophil [nTPM]" "Blood RNA - NK-cell [nTPM]" "Blood RNA - non-classical monocyte [nTPM]" "Blood RNA - plasmacytoid DC [nTPM]" "Blood RNA - T-reg [nTPM]" "Blood RNA - total PBMC [nTPM]" "Brain RNA - amygdala [nTPM]" "Brain RNA - basal ganglia [nTPM]" "Brain RNA - cerebellum [nTPM]" "Brain RNA - cerebral cortex [nTPM]" "Brain RNA - hippocampal formation [nTPM]" "Brain RNA - hypothalamus [nTPM]" "Brain RNA - medulla oblongata [nTPM]" "Brain RNA - midbrain [nTPM]" "Brain RNA - pons [nTPM]" "Brain RNA - spinal cord [nTPM]" "Brain RNA - thalamus [nTPM]" "Brain RNA - white matter [nTPM]" "Single Cell Type RNA - Adipocytes [nTPM]" "Single Cell Type RNA - Alveolar cells type 1 [nTPM]" "Single Cell Type RNA - Alveolar cells type 2 [nTPM]" "Single Cell Type RNA - Astrocytes [nTPM]" "Single Cell Type RNA - B-cells [nTPM]" "Single Cell Type RNA - Basal keratinocytes [nTPM]" "Single Cell Type RNA - Basal prostatic cells [nTPM]" "Single Cell Type RNA - Basal respiratory cells [nTPM]" "Single Cell Type RNA - Basal squamous epithelial cells [nTPM]" "Single Cell Type RNA - Bipolar cells [nTPM]" "Single Cell Type RNA - Breast glandular cells [nTPM]" "Single Cell Type RNA - Breast myoepithelial cells [nTPM]" "Single Cell Type RNA - Cardiomyocytes [nTPM]" "Single Cell Type RNA - Cholangiocytes [nTPM]" "Single Cell Type RNA - Club cells [nTPM]" "Single Cell Type RNA - Collecting duct cells [nTPM]" "Single Cell Type RNA - Cone photoreceptor cells [nTPM]" "Single Cell Type RNA - Cytotrophoblasts [nTPM]" "Single Cell Type RNA - dendritic cells [nTPM]" "Single Cell Type RNA - Distal enterocytes [nTPM]" "Single Cell Type RNA - Distal tubular cells [nTPM]" "Single Cell Type RNA - Ductal cells [nTPM]" "Single Cell Type RNA - Early spermatids [nTPM]" "Single Cell Type RNA - Endometrial ciliated cells [nTPM]" "Single Cell Type RNA - Endometrial stromal cells [nTPM]" "Single Cell Type RNA - Endothelial cells [nTPM]" "Single Cell Type RNA - Enteroendocrine cells [nTPM]" "Single Cell Type RNA - Erythroid cells [nTPM]" "Single Cell Type RNA - Excitatory neurons [nTPM]" "Single Cell Type RNA - Exocrine glandular cells [nTPM]" "Single Cell Type RNA - Extravillous trophoblasts [nTPM]" "Single Cell Type RNA - Fibroblasts [nTPM]" "Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]" "Single Cell Type RNA - Glandular and luminal cells [nTPM]" "Single Cell Type RNA - granulocytes [nTPM]" "Single Cell Type RNA - Granulosa cells [nTPM]" "Single Cell Type RNA - Hepatic stellate cells [nTPM]" "Single Cell Type RNA - Hepatocytes [nTPM]" "Single Cell Type RNA - Hofbauer cells [nTPM]" "Single Cell Type RNA - Horizontal cells [nTPM]" "Single Cell Type RNA - Inhibitory neurons [nTPM]" "Single Cell Type RNA - Intestinal goblet cells [nTPM]" "Single Cell Type RNA - Ionocytes [nTPM]" "Single Cell Type RNA - Kupffer cells [nTPM]" "Single Cell Type RNA - Langerhans cells [nTPM]" "Single Cell Type RNA - Late spermatids [nTPM]" "Single Cell Type RNA - Leydig cells [nTPM]" "Single Cell Type RNA - Macrophages [nTPM]" "Single Cell Type RNA - Melanocytes [nTPM]" "Single Cell Type RNA - Microglial cells [nTPM]" "Single Cell Type RNA - monocytes [nTPM]" "Single Cell Type RNA - Muller glia cells [nTPM]" "Single Cell Type RNA - NK-cells [nTPM]" "Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]" "Single Cell Type RNA - Oligodendrocytes [nTPM]" "Single Cell Type RNA - Pancreatic endocrine cells [nTPM]" "Single Cell Type RNA - Paneth cells [nTPM]" "Single Cell Type RNA - Peritubular cells [nTPM]" "Single Cell Type RNA - Plasma cells [nTPM]" "Single Cell Type RNA - Prostatic glandular cells [nTPM]" "Single Cell Type RNA - Proximal enterocytes [nTPM]" "Single Cell Type RNA - Proximal tubular cells [nTPM]" "Single Cell Type RNA - Respiratory ciliated cells [nTPM]" "Single Cell Type RNA - Rod photoreceptor cells [nTPM]" "Single Cell Type RNA - Sertoli cells [nTPM]" "Single Cell Type RNA - Skeletal myocytes [nTPM]" "Single Cell Type RNA - Smooth muscle cells [nTPM]" "Single Cell Type RNA - Spermatocytes [nTPM]" "Single Cell Type RNA - Spermatogonia [nTPM]" "Single Cell Type RNA - Squamous epithelial cells [nTPM]" "Single Cell Type RNA - Suprabasal keratinocytes [nTPM]" "Single Cell Type RNA - Syncytiotrophoblasts [nTPM]" "Single Cell Type RNA - T-cells [nTPM]" "Single Cell Type RNA - Theca cells [nTPM]" "Single Cell Type RNA - Undifferentiated cells [nTPM]" "Single Cell Type RNA - Urothelial cells [nTPM]" ABL1 "ABL, c-ABL, JTK7, p150" ENSG00000097007 "ABL proto-oncogene 1, non-receptor tyrosine kinase" P00519 9 130713016-130887675 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Autophagy, Cell adhesion, DNA damage, DNA repair, Endocytosis" "DNA-binding, Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Microglial cells: 71.2;Oligodendrocytes: 116.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002686, HPA027251, HPA027280, HPA028409" Supported Enhanced "Nucleoplasm,Nuclear bodies" Yes No "Cluster 37: B-cells - Transcription" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 1: K-562 - Erythropoiesis" "Cluster 50: Fibroblasts - ECM organization" Nucleoplasm "Nuclear bodies" "CAB002686: , HPA027251: AB_1844453, HPA027280: AB_1844454, HPA028409: AB_10601011" "unprognostic (4.82e-2)" "unprognostic (3.99e-2)" "unprognostic (5.55e-2)" "unprognostic (4.72e-2)" "unprognostic (1.16e-1)" "unprognostic (1.46e-1)" "unprognostic (3.75e-3)" "unprognostic (1.89e-3)" "unprognostic (2.34e-1)" "unprognostic (2.54e-2)" "unprognostic (1.09e-2)" "unprognostic (1.48e-1)" "unprognostic (3.96e-3)" "unprognostic (1.10e-2)" "unprognostic (1.47e-1)" "unprognostic (1.22e-1)" "unprognostic (1.06e-1)" 50.9 30.7 27.4 25.3 38.9 23.4 45.8 33.6 31.4 60.5 40.4 96.4 23.1 63.0 11.6 33.8 55.6 35.7 36.1 26.6 28.3 23.1 17.5 37.3 16.3 39.3 38.5 56.0 24.9 32.5 34.9 26.5 35.8 43.5 26.7 14.2 32.4 33.6 29.4 36.3 45.2 41.2 31.3 23.3 51.6 20.1 34.9 22.4 46.7 30.8 15.4 79.3 42.7 41.3 22.5 48.3 53.6 62.9 76.5 93.3 18.8 38.8 60.4 44.8 38.1 36.4 28.3 32.3 22.3 52.0 47.6 42.5 23.5 36.0 30.7 20.6 16.3 23.7 84.1 33.4 51.8 36.5 32.3 68.8 37.2 80.6 50.0 64.1 61.0 47.9 135.8 26.5 54.9 42.0 49.2 30.5 57.9 34.3 33.8 55.9 67.9 35.9 45.0 25.7 47.9 60.1 66.1 23.5 29.2 31.0 46.2 33.1 71.1 170.7 44.1 66.3 62.6 8.4 20.3 47.9 72.1 27.6 55.1 0.0 0.7 0.3 0.6 0.4 0.8 1.3 0.6 0.6 0.7 0.4 0.6 0.5 0.0 0.8 1.9 1.0 0.3 0.6 27.4 38.9 33.6 31.4 26.6 28.3 39.3 38.5 35.8 31.3 34.9 41.3 16.2 9.6 13.6 54.9 4.7 9.2 7.3 9.8 5.2 8.2 11.6 10.2 6.2 7.2 7.2 14.7 12.5 13.6 12.1 21.2 1.9 14.4 5.9 8.6 29.7 18.1 22.1 4.6 52.5 11.1 4.3 36.7 5.6 12.4 2.5 22.1 20.3 15.9 16.6 10.1 63.7 17.5 6.1 16.4 11.7 8.8 28.0 10.2 5.4 71.2 6.6 19.2 6.2 66.9 116.0 17.9 18.3 25.6 5.6 8.6 11.6 10.3 7.8 9.1 19.7 29.5 19.8 16.9 16.5 6.6 6.8 15.2 7.9 20.1 21.4 7.2 ABL2 "ABLL, ARG" ENSG00000143322 "ABL proto-oncogene 2, non-receptor tyrosine kinase" P42684 1 179099330-179229684 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Cell adhesion" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 166.8;Langerhans cells: 188.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in all" "hTERT-HME1: 73.5;TIME: 70.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001866, CAB017106, HPA072754" Uncertain Approved Nucleoplasm,Vesicles NA NA "Cluster 6: Non-specific - Transcription" "Cluster 57: Non-specific - Angiogenesis" "Cluster 17: WM-115 - Nervous system development" "Cluster 41: Macrophages - Immune response" Nucleoplasm Vesicles "CAB017106: , HPA001866: AB_1078082, HPA072754: AB_2732212" "unprognostic (3.05e-1)" "prognostic unfavorable (3.50e-4)" "unprognostic (1.07e-1)" "unprognostic (4.71e-2)" "unprognostic (9.45e-2)" "unprognostic (8.23e-3)" "unprognostic (1.91e-2)" "unprognostic (4.81e-3)" "unprognostic (1.26e-1)" "unprognostic (6.98e-2)" "unprognostic (1.12e-1)" "unprognostic (3.73e-1)" "prognostic unfavorable (1.78e-7)" "unprognostic (4.76e-2)" "unprognostic (4.14e-2)" "unprognostic (6.08e-2)" "prognostic unfavorable (8.40e-4)" 9.3 3.2 5.9 4.9 6.7 2.7 5.7 6.1 6.1 5.4 2.0 4.6 2.8 3.7 2.7 2.5 3.2 11.8 3.9 7.4 5.0 3.6 2.7 6.5 2.7 3.8 4.4 3.5 5.7 4.2 3.8 4.1 3.9 3.5 3.3 9.2 3.5 2.6 3.1 4.2 3.2 4.5 3.0 2.7 3.7 4.4 5.6 4.1 3.8 4.2 2.5 6.4 4.0 4.8 24.2 13.1 8.7 5.8 7.3 16.8 5.3 26.3 21.6 31.9 23.1 9.9 7.2 13.7 18.9 19.2 21.7 11.0 12.6 9.1 44.6 8.5 11.4 6.7 12.4 4.9 13.3 7.5 2.1 15.6 11.6 45.3 73.5 13.9 36.2 7.0 16.1 3.8 42.6 6.5 5.9 4.0 8.3 5.0 4.3 8.6 14.4 6.5 10.8 4.0 5.2 11.9 22.0 7.0 53.8 13.2 6.2 6.4 70.7 33.3 24.5 15.7 42.8 7.0 9.3 14.1 15.6 4.0 32.4 1.4 0.3 0.0 0.5 0.1 0.2 0.5 0.3 0.3 0.2 0.7 0.4 0.5 0.6 0.5 0.1 0.5 0.2 0.1 5.9 6.7 6.1 6.1 7.4 5.0 3.8 4.4 3.9 3.0 5.6 4.8 33.5 22.4 24.0 44.1 14.4 46.9 43.6 16.3 12.5 40.0 18.7 9.5 8.9 22.8 10.8 11.0 166.8 9.3 7.7 15.5 11.7 14.3 15.6 12.3 23.4 67.2 27.0 9.9 81.6 13.9 8.2 67.6 10.2 21.5 17.1 19.5 31.1 15.3 22.9 25.2 62.0 11.0 10.2 34.9 188.1 32.2 15.2 67.7 69.4 45.0 13.9 11.3 8.2 72.4 57.1 45.5 16.0 13.5 10.3 42.6 9.9 9.4 11.0 35.7 6.6 32.3 30.5 17.8 30.5 11.5 38.4 10.4 12.4 11.6 14.9 25.3 ACP1 "HAAP, LMW-PTP, LMWPTP" ENSG00000143727 "Acid phosphatase 1" P24666 2 264140-278283 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 5 "Early spermatids: 1061.1;Late spermatids: 2128.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" HPA016754 Approved Approved Nucleoplasm,Cytosol NA NA 2000000 "Cluster 44: Non-specific - Transcription" "Cluster 29: Non-specific - Vesicular transport" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 34: Spermatids - Unknown function" Nucleoplasm Cytosol "HPA016754: AB_1844505" "unprognostic (1.15e-1)" "unprognostic (1.36e-1)" "unprognostic (1.37e-2)" "unprognostic (6.25e-3)" "unprognostic (1.06e-2)" "unprognostic (1.43e-1)" "prognostic unfavorable (6.67e-6)" "unprognostic (2.45e-1)" "prognostic unfavorable (3.04e-4)" "unprognostic (9.72e-3)" "unprognostic (4.89e-2)" "unprognostic (2.71e-2)" "unprognostic (7.10e-2)" "unprognostic (2.88e-2)" "unprognostic (3.39e-2)" "unprognostic (1.92e-1)" "unprognostic (2.44e-2)" 41.2 104.0 43.1 45.5 47.6 91.9 64.7 43.9 54.0 43.4 63.9 61.4 64.0 46.6 69.3 43.3 57.9 45.4 57.3 49.4 47.1 78.1 106.4 46.8 66.2 43.4 44.2 59.2 94.1 73.9 59.2 61.7 44.3 52.1 64.7 72.7 71.1 44.2 76.6 41.3 60.7 41.5 44.9 44.7 67.1 46.1 45.3 66.2 63.7 74.9 61.9 47.5 36.4 50.2 78.3 112.5 177.4 97.4 76.1 77.1 142.2 92.6 97.7 91.9 80.8 151.7 78.5 48.8 70.7 85.1 114.6 76.5 169.4 97.0 82.3 118.7 157.9 142.3 99.0 348.5 105.7 162.5 80.4 78.7 90.5 81.9 102.3 95.5 105.8 176.9 145.1 95.1 110.9 103.1 178.5 161.3 214.1 204.7 111.7 118.2 176.1 114.5 144.2 110.5 191.6 191.3 56.0 137.6 196.3 115.0 82.1 89.8 88.9 101.3 65.2 84.0 142.6 123.8 261.2 150.4 120.0 138.9 123.7 65.4 61.6 57.2 88.8 75.2 118.1 106.6 100.4 103.2 57.3 97.2 118.1 115.2 10.9 121.5 80.2 65.3 117.6 115.0 43.1 47.6 43.9 54.0 49.4 47.1 43.4 44.2 44.3 44.9 45.3 50.2 62.5 44.8 96.7 9.1 102.6 79.2 105.3 173.4 51.8 53.1 118.8 130.0 84.9 131.5 119.6 68.0 8.4 207.1 101.3 81.9 270.1 226.7 1061.1 113.1 56.2 70.6 82.5 291.5 20.4 169.0 279.7 74.2 54.6 85.5 70.3 95.9 56.0 115.8 141.1 28.6 21.0 125.1 126.1 72.0 66.3 2128.2 94.4 74.6 81.8 16.9 117.8 92.2 152.4 19.6 26.0 174.4 109.2 92.2 106.4 187.0 174.2 306.6 128.1 56.9 92.1 42.5 87.0 122.6 137.4 87.4 91.2 187.7 86.0 124.4 143.9 148.3 ADPRH ARH1 ENSG00000144843 "ADP-ribosylarginine hydrolase" P54922 3 119579268-119589945 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Macrophages: 14.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HDLM-2: 23.9;HEL: 17.1;HMC-1: 18.5;Karpas-707: 25.3;U-266/70: 24.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001701, HPA036961" Approved Approved "Nucleoplasm,Nuclear membrane" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 16: Immune cells - Immune response" "Cluster 2: Karpas-707 - Immune response" "Cluster 4: Macrophages - Innate immune response" "Nuclear membrane" Nucleoplasm "CAB001701: , HPA036961: AB_2675405" "prognostic favorable (2.42e-4)" "unprognostic (2.29e-1)" "unprognostic (4.77e-1)" "unprognostic (2.39e-2)" "unprognostic (3.38e-2)" "unprognostic (2.65e-1)" "unprognostic (3.06e-2)" "unprognostic (2.63e-1)" "unprognostic (4.24e-2)" "unprognostic (3.31e-3)" "unprognostic (1.88e-1)" "unprognostic (1.71e-1)" "unprognostic (6.04e-2)" "unprognostic (2.60e-3)" "unprognostic (8.87e-2)" "unprognostic (2.03e-1)" "unprognostic (4.35e-2)" 10.6 6.2 3.0 7.3 3.3 3.4 7.9 3.3 4.2 6.9 9.2 5.5 2.3 6.0 4.9 4.0 4.2 6.9 8.5 2.9 3.5 4.9 3.1 13.5 11.0 4.6 3.4 1.9 6.7 8.0 2.0 11.3 4.4 6.1 4.1 6.6 5.1 9.3 11.8 2.6 5.4 9.2 4.2 11.9 3.9 2.4 4.6 5.9 5.8 9.9 13.0 6.5 3.4 4.9 2.4 3.0 0.7 0.0 2.4 2.7 0.0 2.1 0.4 1.8 2.3 0.9 2.0 0.6 0.9 3.2 0.1 0.2 2.0 0.0 1.7 23.9 0.2 17.1 0.4 0.0 3.9 0.1 18.5 4.0 0.1 0.9 0.1 0.8 7.3 0.0 1.6 25.3 11.0 0.7 0.0 4.1 6.9 0.2 5.8 0.0 8.2 1.1 1.0 0.9 0.5 0.1 0.0 0.1 6.4 1.0 4.4 10.6 6.0 0.0 1.1 4.6 0.4 24.5 5.8 0.1 3.0 0.0 4.6 13.9 18.7 19.1 0.8 17.2 0.8 11.0 1.9 1.7 11.2 6.8 0.2 0.7 0.6 5.3 13.9 9.8 14.3 7.5 3.0 3.3 3.3 4.2 2.9 3.5 4.6 3.4 4.4 4.2 4.6 4.9 12.6 9.6 8.6 0.3 5.0 0.8 0.7 0.4 0.0 0.5 1.5 1.9 4.7 2.8 2.7 3.7 4.2 5.8 5.0 0.3 1.9 3.6 0.7 0.2 0.9 9.9 0.0 2.7 0.1 3.2 3.8 2.1 2.6 0.5 10.8 2.5 7.1 1.6 9.4 0.0 0.2 0.2 2.0 12.2 11.1 0.5 0.3 14.8 1.8 4.7 10.2 0.8 4.1 0.0 0.6 2.1 0.5 3.0 3.9 0.7 0.0 1.3 2.1 4.3 0.0 3.6 3.9 0.4 0.6 0.1 0.9 11.8 1.2 0.7 0.2 0.2 ALK CD246 ENSG00000171094 "ALK receptor tyrosine kinase" Q9UM73 2 29192774-29921586 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 8 "brain: 10.9" "Group enriched" "Detected in some" 5 "Inhibitory neurons: 274.2;Oligodendrocyte precursor cells: 433.8" "Group enriched" "Detected in some" 5 "glioma: 1.0;melanoma: 1.5;ovarian cancer: 0.7;thyroid cancer: 1.3" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 6 "SH-SY5Y: 31.7" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA010694 Approved Supported "Plasma membrane" NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane" "HPA010694: AB_1078133" "unprognostic (4.96e-2)" "unprognostic (1.11e-2)" "unprognostic (1.45e-1)" "unprognostic (4.56e-7)" "unprognostic (7.17e-2)" "unprognostic (1.71e-1)" "unprognostic (9.07e-3)" "unprognostic (6.29e-3)" "unprognostic (1.18e-1)" "unprognostic (1.01e-1)" "unprognostic (2.67e-4)" "unprognostic (3.70e-2)" "unprognostic (2.06e-2)" "unprognostic (7.15e-2)" "unprognostic (1.98e-1)" "unprognostic (1.38e-1)" "unprognostic (3.61e-2)" 0.3 0.6 2.2 0.2 2.4 0.0 0.1 0.7 2.8 0.1 0.8 0.6 0.1 0.0 0.0 0.0 0.0 0.2 0.0 1.5 3.9 0.0 0.0 0.1 0.0 4.4 6.8 0.0 0.0 0.0 1.3 0.0 10.9 0.0 0.2 0.7 0.1 0.1 0.0 0.1 0.3 0.1 2.9 0.0 0.1 1.2 2.7 0.0 0.3 0.0 0.0 0.0 0.0 2.1 0.1 0.0 0.5 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.6 0.0 4.3 0.0 0.0 0.1 0.4 31.7 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 3.7 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 2.4 0.7 2.8 1.5 3.9 4.4 6.8 10.9 2.9 2.7 2.1 0.0 0.0 0.0 66.6 0.0 0.0 0.0 0.0 0.0 1.9 0.2 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 42.1 0.5 0.1 0.2 0.0 0.0 12.5 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 3.4 0.0 274.2 0.0 0.0 0.0 0.0 41.2 0.0 0.5 0.0 7.5 0.0 0.6 0.0 433.8 21.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.1 0.1 0.8 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 AXL "ARK, JTK11, Tyro7, UFO" ENSG00000167601 "AXL receptor tyrosine kinase" P30530 19 41219223-41261766 "Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Differentiation, Host-virus interaction, Immunity, Innate immunity" "Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "FDA approved drug targets, Oncogene, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Fibroblasts: 147.2;Kupffer cells: 187.5;Langerhans cells: 185.5;Prostatic glandular cells: 123.4;Sertoli cells: 210.4;Smooth muscle cells: 171.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "NK-cell: 11.1;plasmacytoid DC: 25.7" "Group enriched" "Detected in many" 12 "dendritic cells: 25.7;NK-cells: 11.1" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 501.2;U-251 MG: 540.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032501, HPA037422, HPA037423, HPA075217" Uncertain Supported "Vesicles,Plasma membrane,Actin filaments" NA Yes 12100000 72000000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 57: Non-specific - Angiogenesis" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 48: Smooth muscle cells - ECM organization" "Plasma membrane" "Vesicles, Actin filaments" "CAB032501: AB_2062572, HPA037422: AB_10672347, HPA037423: AB_2675470, HPA075217: " "unprognostic (2.20e-1)" "unprognostic (2.02e-1)" "unprognostic (6.79e-3)" "unprognostic (1.01e-1)" "unprognostic (1.40e-1)" "unprognostic (8.49e-3)" "unprognostic (2.42e-1)" "unprognostic (1.74e-1)" "unprognostic (3.15e-2)" "unprognostic (2.82e-2)" "unprognostic (9.57e-3)" "unprognostic (1.98e-1)" "prognostic unfavorable (2.53e-7)" "unprognostic (1.16e-3)" "unprognostic (1.52e-2)" "unprognostic (5.56e-2)" "unprognostic (4.83e-3)" 43.6 18.8 17.5 15.5 22.6 1.7 26.6 19.7 17.7 36.1 12.4 42.5 11.7 34.4 8.7 17.6 25.4 22.4 26.7 16.6 18.8 9.8 15.0 25.9 6.2 26.8 20.6 24.7 6.3 10.7 7.3 34.2 22.1 19.2 12.6 5.8 10.6 24.6 9.4 20.0 19.0 37.1 20.9 37.7 21.4 18.6 24.0 7.2 16.6 11.3 5.0 32.5 25.2 21.9 408.0 160.0 9.7 1.3 34.6 34.7 0.5 314.5 280.2 450.9 278.2 8.5 185.5 0.2 124.7 501.2 235.3 33.3 0.4 211.8 384.8 0.7 0.3 0.0 100.4 6.3 125.0 0.3 0.3 26.4 3.8 266.7 409.5 254.8 169.8 0.1 15.8 0.5 284.6 0.5 0.2 0.4 4.1 1.0 76.3 0.2 165.3 0.3 202.3 0.2 0.1 0.1 81.5 0.6 1.8 57.4 0.9 7.2 351.8 317.8 214.6 307.7 540.8 0.5 0.9 1.0 211.5 0.5 241.8 1.5 0.3 0.2 0.1 0.4 0.2 0.1 0.3 0.1 6.0 0.1 0.3 0.3 0.3 11.1 0.2 25.7 0.4 0.3 17.5 22.6 19.7 17.7 16.6 18.8 26.8 20.6 22.1 20.9 24.0 21.9 13.5 9.6 3.6 35.9 1.9 41.7 88.3 10.3 3.4 0.5 2.3 14.2 8.6 1.5 4.4 5.5 0.0 4.2 0.8 0.1 0.0 6.9 8.7 6.0 45.8 17.7 0.0 0.0 0.8 0.2 2.1 147.2 1.5 5.4 0.0 17.3 11.0 1.2 28.8 1.7 1.1 0.1 2.0 187.5 185.5 5.5 61.5 61.4 26.6 30.9 3.1 26.8 0.0 11.1 0.5 14.5 0.1 79.7 0.8 123.4 0.3 0.1 2.8 1.2 210.4 38.1 171.1 1.9 2.0 1.2 29.1 11.5 3.6 2.5 0.1 28.0 BLK MGC10442 ENSG00000136573 "BLK proto-oncogene, Src family tyrosine kinase" P51451 8 11486894-11564599 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Diabetes mellitus" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 16 "intestine: 39.1;lymphoid tissue: 46.7" "Cell type enriched" "Detected in some" 11 "B-cells: 116.0" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Group enriched" "Detected in many" 4 "memory B-cell: 183.4;naive B-cell: 131.5" "Lineage enriched" "Detected in many" 5 "B-cells: 183.4" "Cell line enhanced" "Detected in some" "Daudi: 106.6;REH: 29.9;RPMI-8226: 38.5;U-698: 48.6;U-87 MG: 22.7" "Not detected" "Not detected" "Not detected" "Not detected" "CAB005093, HPA069571" Approved Uncertain Nucleoplasm NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 16: Immune cells - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 57: B-cells - Immune response" Nucleoplasm "CAB005093: AB_2274756, HPA069571: AB_2732137" "unprognostic (6.50e-5)" "unprognostic (4.22e-3)" "unprognostic (5.64e-2)" "unprognostic (1.42e-1)" "unprognostic (3.45e-1)" "unprognostic (5.98e-6)" "unprognostic (1.59e-2)" "unprognostic (8.94e-4)" "unprognostic (1.02e-3)" "unprognostic (9.83e-3)" "unprognostic (1.22e-2)" "unprognostic (4.66e-2)" "unprognostic (9.05e-6)" "unprognostic (5.62e-2)" "unprognostic (5.43e-2)" "unprognostic (2.19e-1)" "unprognostic (1.16e-1)" 0.5 0.1 0.0 9.1 0.0 2.6 0.2 0.0 0.0 0.0 0.0 2.6 0.5 0.1 0.0 1.2 0.2 0.5 0.1 0.0 0.0 1.2 0.7 0.8 29.9 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.4 0.7 0.0 0.7 0.0 0.3 0.0 39.1 0.1 0.0 46.7 2.1 0.1 0.0 2.5 1.2 0.0 27.9 1.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 106.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.1 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.1 29.9 0.0 38.5 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 5.4 10.2 48.6 22.7 0.0 0.0 0.2 0.1 0.2 2.0 0.0 37.9 183.4 1.4 4.6 0.1 131.5 0.9 0.4 0.7 0.1 0.1 17.5 1.8 9.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 116.0 0.1 0.0 0.0 0.0 0.0 0.1 0.3 0.6 0.0 0.0 0.0 0.0 0.0 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 3.2 0.1 0.0 0.0 0.3 1.1 0.0 0.0 0.0 0.7 0.5 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.8 0.0 1.0 1.3 0.0 0.0 0.5 0.1 0.0 0.0 0.0 10.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.1 0.0 0.0 4.0 0.1 0.1 0.0 BMX "ETK, PSCTK3" ENSG00000102010 "BMX non-receptor tyrosine kinase" P51813 X 15464246-15556529 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell adhesion, Stress response" "Kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 12 "epididymis: 102.6" "Group enriched" "Detected in some" 4 "Endothelial cells: 28.2;Hepatic stellate cells: 93.9" "Cancer enhanced" "Detected in many" "melanoma: 3.2" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 16 "neutrophil: 7.6" "Lineage enriched" "Detected in single" 77 "granulocytes: 7.6" "Cell line enriched" "Detected in some" 119 "HUVEC TERT2: 353.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA001048, CAB032495" Enhanced Supported "Nucleoplasm,Plasma membrane" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 30: Epididymis - Antimicrobial activity" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Plasma membrane" Nucleoplasm "CAB032495: AB_2290760, HPA001048: AB_1078289" "unprognostic (7.80e-2)" "unprognostic (4.92e-3)" "unprognostic (1.16e-2)" "unprognostic (4.07e-3)" "unprognostic (2.69e-1)" "unprognostic (2.14e-1)" "unprognostic (1.06e-3)" "unprognostic (2.36e-1)" "unprognostic (1.87e-1)" "unprognostic (1.21e-1)" "unprognostic (1.78e-1)" "unprognostic (1.06e-1)" "unprognostic (1.26e-2)" "unprognostic (1.84e-2)" "unprognostic (3.64e-2)" "unprognostic (1.26e-1)" "unprognostic (2.81e-2)" 7.7 0.3 0.3 1.7 0.5 7.1 4.9 0.3 0.6 1.7 1.1 3.8 4.4 2.3 102.6 2.3 2.6 2.6 8.8 0.3 0.3 0.6 0.7 3.0 1.5 0.3 0.4 0.9 0.9 0.3 0.2 4.7 0.3 0.9 2.4 0.0 1.1 0.9 1.3 1.6 4.8 2.6 0.3 2.2 1.4 0.2 0.4 0.7 2.0 2.2 0.4 2.6 2.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 353.0 0.0 0.2 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.9 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.6 0.0 0.0 0.0 0.0 0.0 0.3 0.5 0.3 0.6 0.3 0.3 0.3 0.4 0.3 0.3 0.4 0.4 14.1 0.0 1.1 1.3 0.0 0.4 0.7 0.0 0.0 0.0 0.1 0.0 1.6 0.0 0.0 1.8 0.0 0.1 0.0 0.1 0.0 0.0 0.0 3.2 0.0 28.2 4.2 3.2 1.3 0.2 0.0 1.1 4.6 0.2 0.0 0.1 93.9 0.7 0.1 0.0 1.2 0.1 2.0 0.0 1.1 0.0 0.3 0.1 0.0 1.0 0.0 0.0 0.0 0.5 1.5 0.0 0.0 0.0 0.1 0.8 0.1 0.0 0.8 0.0 0.0 0.3 0.8 0.2 0.1 0.2 0.0 0.1 0.2 0.1 0.4 0.4 BTK "AGMX1, ATK, IMD1, PSCTK1, XLA" ENSG00000010671 "Bruton tyrosine kinase" Q06187 X 101349447-101390796 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Adaptive immunity, Apoptosis, Immunity, Innate immunity, Transcription, Transcription regulation" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, Dwarfism, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 32.6;lymphoid tissue: 78.0" "Cell type enhanced" "Detected in some" "B-cells: 84.7;granulocytes: 211.4;Hofbauer cells: 56.6;Kupffer cells: 63.5;Macrophages: 61.1;monocytes: 71.1;Plasma cells: 43.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 4 "basophil: 557.5" "Lineage enriched" "Detected in many" 4 "granulocytes: 557.5" "Cell line enhanced" "Detected in some" "Daudi: 206.7;HEL: 287.4;HMC-1: 990.3;U-937: 149.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA001198, HPA002028, CAB016689" Enhanced Supported "Plasma membrane,Cytosol" NA NA 2300000 "Cluster 38: Basophils - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 57: B-cells - Immune response" "Plasma membrane, Cytosol" "CAB016689: AB_1611894, HPA001198: AB_1078305, HPA002028: AB_1078306" "unprognostic (3.19e-2)" "unprognostic (2.51e-3)" "unprognostic (1.06e-2)" "unprognostic (3.66e-2)" "unprognostic (5.69e-2)" "unprognostic (3.76e-3)" "unprognostic (6.55e-2)" "unprognostic (3.58e-3)" "unprognostic (6.02e-2)" "unprognostic (3.12e-1)" "unprognostic (1.02e-1)" "unprognostic (1.41e-1)" "unprognostic (2.08e-3)" "unprognostic (7.80e-2)" "unprognostic (1.29e-2)" "unprognostic (1.56e-2)" "unprognostic (8.14e-2)" 6.3 2.9 2.3 30.7 2.6 32.6 4.4 2.8 3.4 3.9 3.1 6.6 4.8 2.5 1.5 3.6 1.9 7.6 1.6 2.3 3.1 1.3 5.4 19.6 55.5 4.7 3.6 0.8 1.2 0.9 0.9 7.0 4.7 1.9 9.1 0.3 2.8 2.3 0.6 2.9 14.7 7.1 3.8 38.4 7.0 1.4 3.9 9.3 1.3 2.0 78.0 9.3 1.5 6.5 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.0 0.0 206.7 0.0 0.0 0.1 0.5 0.0 0.0 0.1 0.0 0.3 287.4 0.0 0.0 0.0 116.7 990.3 0.0 0.0 0.1 0.0 0.0 0.0 0.2 61.9 2.3 0.0 0.0 0.6 81.5 1.6 0.0 0.0 87.2 0.1 13.2 0.0 0.0 0.2 0.0 0.3 0.1 0.5 1.0 0.0 68.5 0.4 0.0 0.3 0.2 0.1 2.6 1.4 98.3 0.5 149.8 0.3 557.5 62.2 110.5 0.2 99.9 0.2 72.4 0.2 0.1 72.7 73.0 0.4 0.1 24.7 0.2 123.9 33.1 0.1 38.4 2.3 2.6 2.8 3.4 2.3 3.1 4.7 3.6 4.7 3.8 3.9 6.5 1.5 3.2 8.9 0.3 84.7 1.0 0.2 0.0 0.6 0.0 0.9 1.4 0.6 0.0 0.6 0.0 0.0 1.4 30.1 0.1 0.0 0.0 0.2 1.3 0.3 0.8 0.0 27.1 0.5 0.0 0.5 0.9 1.1 2.3 211.4 0.0 0.7 0.3 56.6 0.0 0.3 0.3 0.0 63.5 31.0 0.1 0.3 61.1 3.6 10.3 71.1 0.0 2.1 0.0 0.1 0.1 0.5 0.0 43.8 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.5 0.7 1.7 0.5 0.3 1.9 5.7 0.2 0.1 0.1 CDC14A "cdc14, Cdc14A1, Cdc14A2, DFNB105, DFNB32" ENSG00000079335 "Cell division cycle 14A" Q9UNH5 1 100345001-100520277 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Hearing" "Hydrolase, Protein phosphatase" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 28.2" "Cell type enhanced" "Detected in many" "Astrocytes: 145.9;Early spermatids: 171.5;Late spermatids: 191.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "K-562: 44.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA023783 Approved Supported "Nucleoplasm,Nuclear bodies,Cytosol" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 23: Testis - Cell cycle regulation" "Cluster 1: K-562 - Erythropoiesis" "Cluster 34: Spermatids - Unknown function" Nucleoplasm "Nuclear bodies, Cytosol" "HPA023783: AB_1846352" "unprognostic (3.72e-2)" "unprognostic (2.38e-2)" "unprognostic (1.84e-2)" "unprognostic (2.98e-2)" "unprognostic (1.54e-3)" "unprognostic (1.38e-1)" "unprognostic (9.27e-4)" "unprognostic (4.88e-3)" "unprognostic (6.30e-2)" "unprognostic (3.97e-3)" "unprognostic (8.83e-2)" "unprognostic (1.23e-1)" "unprognostic (1.79e-3)" "unprognostic (6.29e-2)" "unprognostic (2.04e-1)" "unprognostic (1.49e-2)" "unprognostic (6.66e-2)" 3.6 1.5 3.9 4.6 3.1 15.5 11.3 2.7 4.2 5.4 5.2 6.0 7.3 5.3 2.7 2.2 13.0 3.3 2.3 3.7 4.5 6.3 1.8 5.9 7.2 4.3 4.9 4.6 2.0 6.0 3.6 5.1 3.3 7.6 6.0 5.5 3.4 3.0 2.6 3.8 10.7 4.7 3.5 6.7 5.8 28.2 3.6 6.4 5.8 2.8 4.4 4.4 3.3 3.2 3.3 2.6 8.1 9.3 2.9 2.1 5.7 4.1 2.7 3.9 3.1 8.9 2.7 1.6 3.0 2.4 3.2 2.5 5.6 2.3 4.0 3.4 13.7 5.8 2.3 2.9 1.1 7.8 9.8 1.8 0.6 4.3 1.4 2.0 7.0 3.3 44.7 4.8 5.8 1.4 6.3 8.7 5.1 2.1 3.3 6.8 10.6 1.7 2.8 7.2 1.5 2.7 4.3 4.1 5.6 3.9 1.9 10.0 3.1 2.2 4.9 3.8 2.5 2.4 0.9 2.5 2.7 7.3 1.3 12.2 3.6 9.0 6.9 3.3 12.5 4.5 10.9 8.2 3.5 2.9 10.2 5.5 5.4 4.4 2.3 6.2 6.0 4.1 3.9 3.1 2.7 4.2 3.7 4.5 4.3 4.9 3.3 3.5 3.6 3.2 14.1 3.2 5.5 145.9 10.6 3.7 4.5 1.7 4.6 0.4 15.8 11.0 6.6 0.0 4.4 1.8 4.2 2.7 23.2 18.4 0.0 3.0 171.5 48.3 11.8 13.5 4.8 3.8 4.3 1.9 1.0 7.0 6.6 51.1 15.2 4.8 7.1 1.0 2.8 0.0 1.4 4.0 2.0 5.5 7.3 191.7 5.0 11.1 5.4 51.5 9.3 11.4 6.2 53.8 3.6 3.1 11.2 0.7 13.5 5.2 22.9 2.5 22.5 3.8 0.0 6.2 6.0 2.3 3.6 4.9 2.4 2.2 44.1 3.0 3.7 4.1 CDC14B "Cdc14B1, Cdc14B2, CDC14B3, hCDC14B" ENSG00000081377 "Cell division cycle 14B" O60729 9 96490241-96619843 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "DNA damage, DNA repair" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 27.3" "Cell type enhanced" "Detected in many" "Astrocytes: 86.5;Excitatory neurons: 83.5;Inhibitory neurons: 110.2;Oligodendrocyte precursor cells: 156.9;Oligodendrocytes: 273.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "basophil: 10.4" "Lineage enriched" "Detected in many" 5 "granulocytes: 10.4" "Cell line enhanced" "Detected in many" "ASC TERT1: 30.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA064747 Supported Nucleoplasm NA NA "Cluster 34: Basophils - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA064747: AB_2732719" "unprognostic (5.69e-2)" "unprognostic (9.09e-2)" "unprognostic (3.50e-2)" "unprognostic (8.08e-3)" "unprognostic (4.24e-1)" "unprognostic (1.19e-2)" "unprognostic (1.11e-2)" "unprognostic (4.49e-2)" "unprognostic (1.63e-2)" "unprognostic (2.27e-2)" "unprognostic (2.35e-1)" "unprognostic (2.75e-1)" "prognostic favorable (2.97e-10)" "unprognostic (2.01e-2)" "unprognostic (2.61e-1)" "prognostic unfavorable (2.82e-4)" "unprognostic (7.40e-2)" 4.3 2.3 11.1 1.1 15.8 3.0 3.0 6.1 11.7 2.9 1.4 3.1 2.8 1.3 2.0 1.4 4.2 2.9 5.0 5.2 6.9 5.5 10.3 3.0 0.9 11.0 12.1 3.4 4.6 6.9 1.1 2.0 11.4 3.3 3.3 1.7 1.8 4.1 0.7 0.8 3.3 1.7 10.4 0.8 6.1 9.3 11.4 2.9 8.5 1.4 1.2 4.1 0.8 27.3 7.4 4.1 4.2 4.4 20.2 30.1 11.6 5.3 7.0 3.5 5.6 14.0 11.6 0.0 5.0 11.3 8.4 8.1 6.1 4.0 4.1 1.9 5.8 1.1 1.5 11.2 3.3 0.0 0.2 12.4 2.1 3.7 3.4 4.0 0.7 0.0 4.4 0.8 4.8 3.5 0.0 1.2 7.9 8.4 3.6 0.0 2.6 0.2 5.4 11.3 1.3 6.6 3.7 1.1 2.0 14.2 0.9 2.3 2.2 3.5 4.1 9.0 3.9 0.1 0.0 0.0 3.7 0.0 8.3 10.4 0.0 2.2 2.0 0.0 1.0 1.1 0.8 1.5 0.0 0.4 1.4 0.9 0.0 0.1 0.0 0.0 1.1 0.6 11.1 15.8 6.1 11.7 5.2 6.9 11.0 12.1 11.4 10.4 11.4 27.3 4.0 6.4 8.8 86.5 3.7 9.1 8.9 4.4 9.1 7.2 8.4 6.1 17.9 11.5 11.4 9.2 8.4 6.4 2.3 7.1 7.9 5.5 36.9 27.4 7.5 6.2 2.4 0.4 83.5 6.5 3.0 17.3 21.4 33.9 14.5 2.9 6.8 31.2 11.3 8.4 110.2 9.0 8.2 1.6 6.7 33.3 9.0 5.5 8.8 56.2 2.4 12.8 2.1 156.9 273.9 8.6 7.3 11.7 8.3 10.8 16.9 17.0 15.7 12.4 26.3 18.6 15.7 10.8 7.3 4.7 7.7 3.4 4.4 1.2 8.6 13.2 CDC25A ENSG00000164045 "Cell division cycle 25A" P30304 3 48157146-48188417 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Hydrolase, Protein phosphatase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 15.3;lymphoid tissue: 8.8;testis: 13.3" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 111.2;Early spermatids: 18.3;Late spermatids: 31.8;Spermatogonia: 16.3" "Cancer enhanced" "Detected in many" "testis cancer: 19.0" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005855, HPA008803" Approved "Nucleoplasm,Golgi apparatus" NA Yes "Cluster 43: B-cells - Humoral immune response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm "Golgi apparatus" "HPA005855: AB_1846364, HPA008803: " "unprognostic (1.49e-1)" "unprognostic (8.13e-2)" "unprognostic (1.20e-2)" "unprognostic (1.43e-3)" "unprognostic (2.14e-1)" "unprognostic (9.51e-2)" "unprognostic (7.05e-7)" "unprognostic (1.35e-2)" "unprognostic (4.32e-3)" "unprognostic (8.92e-3)" "unprognostic (4.41e-2)" "unprognostic (9.09e-2)" "unprognostic (4.41e-3)" "unprognostic (1.57e-3)" "unprognostic (1.07e-1)" "unprognostic (1.29e-1)" "unprognostic (2.72e-1)" 0.7 0.9 0.8 3.3 0.8 15.3 1.1 0.7 1.0 0.6 0.7 3.5 2.0 0.6 0.9 2.4 0.2 0.3 0.4 0.8 2.0 0.7 0.8 0.3 4.4 1.1 1.9 2.2 0.7 0.8 0.8 2.6 1.7 0.6 3.9 2.0 0.8 0.6 0.4 0.6 1.8 1.1 0.8 2.0 0.9 13.3 2.0 8.8 1.8 0.3 5.6 0.9 0.9 0.7 22.2 10.7 50.0 27.2 1.7 3.2 34.2 29.9 11.3 36.7 29.6 46.8 11.2 64.9 11.4 8.0 23.4 16.3 86.6 20.6 38.6 21.4 45.1 83.8 19.0 23.1 1.7 59.4 23.4 1.7 3.1 45.8 19.6 4.6 14.1 47.8 67.6 33.6 20.1 11.8 74.8 46.6 73.4 20.2 24.2 33.2 32.9 35.1 9.5 20.7 23.5 28.8 18.6 21.6 9.5 31.7 11.3 41.9 7.2 18.0 27.7 20.3 41.4 16.7 54.2 101.5 13.5 65.2 15.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.8 0.7 1.0 0.8 2.0 1.1 1.9 1.7 0.8 2.0 0.7 0.3 0.0 0.0 1.0 1.1 0.4 0.4 0.8 1.8 0.5 1.2 1.0 111.2 0.0 0.1 0.0 2.1 4.2 0.2 2.4 0.0 0.4 18.3 0.5 0.9 2.7 1.2 8.0 0.2 0.9 7.4 1.5 1.5 1.3 0.0 4.6 1.4 0.3 3.1 0.0 0.5 2.0 0.0 0.6 0.9 31.8 1.5 0.5 0.0 0.0 0.1 1.1 0.0 0.5 0.0 1.1 0.8 1.9 13.0 0.7 0.4 0.4 0.2 0.4 0.0 0.1 2.2 14.5 16.3 4.3 0.0 0.3 0.6 2.4 4.1 0.5 CDC25B ENSG00000101224 "Cell division cycle 25B" P30305 20 3786772-3806121 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Hydrolase, Protein phosphatase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in all" 4 "B-cells: 7.2;NK-cells: 18.1;T-cells: 28.2" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038892, HPA038893, HPA075215" Enhanced Uncertain "Vesicles,Mitotic spindle" Yes Yes "Cluster 20: T-cells - T-cell receptor" "Cluster 64: Macrophages - Immune response" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 63: NK-cells & T-cells - Immune response" Vesicles "Mitotic spindle" "HPA038892: AB_2676258, HPA038893: AB_2676259, HPA075215: " "unprognostic (4.69e-2)" "unprognostic (5.74e-2)" "unprognostic (2.93e-2)" "prognostic unfavorable (4.76e-4)" "unprognostic (1.13e-1)" "unprognostic (4.23e-1)" "prognostic unfavorable (1.19e-4)" "unprognostic (1.31e-2)" "unprognostic (4.92e-2)" "unprognostic (2.74e-1)" "unprognostic (1.67e-1)" "unprognostic (6.03e-2)" "prognostic unfavorable (2.94e-13)" "unprognostic (1.15e-1)" "unprognostic (2.38e-1)" "unprognostic (3.94e-1)" "unprognostic (9.46e-2)" 29.2 15.6 30.5 28.8 32.4 29.4 25.1 39.2 33.2 41.7 23.2 37.6 14.4 35.0 9.4 27.1 31.5 17.9 16.3 27.6 32.5 31.3 24.8 78.4 47.6 31.3 29.9 37.4 12.8 3.8 45.7 31.1 30.2 25.4 11.3 7.8 16.7 8.9 10.5 21.8 41.2 14.2 27.4 56.1 30.1 12.4 30.9 44.7 41.8 6.3 32.8 35.8 30.2 35.8 129.6 273.2 36.5 60.0 43.8 43.0 19.3 63.3 95.3 103.1 75.9 49.2 182.9 91.3 27.5 65.4 253.5 183.5 50.6 105.8 50.2 36.2 54.4 49.4 88.5 59.6 178.4 38.6 25.0 41.1 85.0 95.4 115.7 35.6 58.4 44.2 33.3 232.7 63.1 105.5 119.0 57.7 27.3 90.9 116.9 62.0 102.6 67.5 73.2 12.2 25.8 56.9 148.6 140.8 78.1 31.7 48.1 20.4 48.6 55.1 66.2 101.5 85.0 57.8 97.8 36.8 28.1 38.0 54.6 3.9 2.4 0.0 22.7 3.4 21.3 5.8 22.6 23.3 2.4 7.2 18.6 21.6 0.3 18.1 1.7 1.3 28.2 11.2 30.5 32.4 39.2 33.2 27.6 32.5 31.3 29.9 30.2 27.4 30.9 35.8 14.0 9.6 21.7 18.6 21.7 11.2 6.0 10.9 7.4 14.4 4.8 5.5 8.6 8.6 4.5 7.3 2.1 11.9 30.6 5.8 0.0 9.9 0.7 2.7 20.6 27.1 7.8 32.6 39.2 4.8 17.7 15.7 17.3 5.4 1.3 11.5 14.3 13.7 30.4 3.3 38.0 10.4 12.2 14.8 9.4 1.1 7.2 12.4 17.8 6.5 8.8 8.3 44.3 22.6 13.2 15.0 4.3 9.1 49.6 6.0 5.5 11.1 3.7 2.6 0.0 26.5 14.0 2.3 12.3 10.3 11.2 3.6 36.4 7.1 10.9 4.4 CDC25C "CDC25, PPP1R60" ENSG00000158402 "Cell division cycle 25C" P30307 5 138285269-138338355 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Host-virus interaction, Mitosis" "Hydrolase, Protein phosphatase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 5.8;lymphoid tissue: 8.9;testis: 18.1" "Cell type enhanced" "Detected in many" "Early spermatids: 41.4;Late spermatids: 42.1;Spermatocytes: 53.6;Spermatogonia: 13.0" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in single" "Low region specificity" "Detected in many" "CAB003800, HPA066991" Approved Enhanced "Nuclear speckles" No Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 12: Non-specific - Cell cycle regulation" "Nuclear speckles" "CAB003800: AB_562081, HPA066991: AB_2685760" "unprognostic (2.45e-3)" "unprognostic (5.89e-3)" "prognostic favorable (2.49e-4)" "unprognostic (9.72e-3)" "unprognostic (2.17e-1)" "unprognostic (1.53e-1)" "prognostic unfavorable (3.03e-6)" "prognostic unfavorable (4.38e-4)" "unprognostic (5.56e-2)" "unprognostic (2.08e-1)" "unprognostic (1.70e-3)" "unprognostic (1.00e-1)" "unprognostic (0.00e+0)" "unprognostic (5.04e-2)" "unprognostic (1.43e-1)" "unprognostic (2.59e-1)" "unprognostic (3.06e-1)" 0.2 0.2 0.2 2.1 0.2 5.8 0.7 0.3 0.3 0.3 0.2 3.4 3.0 0.4 0.2 1.4 0.2 0.2 0.1 0.2 0.2 0.1 0.5 0.3 3.2 0.2 0.3 0.0 0.4 0.1 0.1 1.2 0.2 0.2 4.1 0.1 0.3 0.1 0.0 1.4 3.0 0.8 0.1 0.9 1.1 18.1 0.2 8.9 0.1 0.0 4.6 0.5 0.5 0.2 27.9 11.0 38.4 28.9 0.9 3.6 9.9 16.4 17.5 36.2 50.3 27.3 52.8 13.3 13.8 10.1 40.5 14.9 31.7 25.9 34.9 11.1 21.5 9.6 15.0 21.2 0.3 6.3 10.0 0.8 0.9 22.0 18.0 3.8 24.6 28.9 14.8 24.2 22.9 15.5 19.3 16.7 9.7 22.3 12.2 11.9 34.2 15.0 6.4 8.4 19.2 11.9 36.8 11.0 16.9 32.6 18.7 13.9 7.2 19.9 16.8 13.9 26.5 15.0 13.4 13.0 8.3 14.3 15.6 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.5 0.0 0.0 0.6 0.1 0.2 0.2 0.3 0.3 0.2 0.2 0.2 0.3 0.2 0.1 0.2 0.2 0.1 0.0 0.0 1.3 0.9 0.6 0.3 1.1 1.8 0.0 0.9 0.8 0.3 0.0 0.2 0.0 0.0 5.0 0.5 1.8 0.0 0.1 41.4 0.4 0.9 0.6 0.0 9.5 1.3 0.0 6.9 1.1 3.6 1.2 0.0 5.5 1.4 0.4 2.7 0.0 1.0 3.9 2.0 0.6 0.5 42.1 1.8 1.2 0.0 1.0 0.6 0.0 0.0 1.0 0.3 0.0 1.4 0.4 4.5 0.3 0.9 0.1 0.1 0.0 0.0 0.2 0.9 53.6 13.0 4.3 0.4 1.4 0.6 0.2 4.9 0.6 CDKN3 "CDI1, KAP" ENSG00000100526 "Cyclin dependent kinase inhibitor 3" Q16667 14 54396849-54420218 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle" "Hydrolase, Protein phosphatase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "testis: 207.0" "Cell type enhanced" "Detected in many" "Early spermatids: 2630.9;Late spermatids: 659.4;Spermatocytes: 606.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "T-reg: 18.8" "Group enriched" "Detected in all" 6 "NK-cells: 6.4;T-cells: 18.8" "Low cell line specificity" "Detected in all" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB005285, HPA039311, HPA058874" Enhanced Cytosol NA Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 29: Early spermatids - Spermatogenesis" Cytosol "CAB005285: AB_2078884, HPA039311: , HPA058874: AB_2683842" "unprognostic (3.46e-2)" "unprognostic (9.95e-2)" "unprognostic (5.79e-2)" "unprognostic (6.78e-3)" "unprognostic (2.73e-1)" "unprognostic (6.08e-2)" "unprognostic (1.51e-3)" "prognostic unfavorable (4.52e-4)" "unprognostic (2.50e-3)" "unprognostic (2.85e-3)" "prognostic unfavorable (7.46e-4)" "unprognostic (5.89e-2)" "prognostic unfavorable (0.00e+0)" "unprognostic (1.71e-1)" "unprognostic (7.30e-2)" "unprognostic (7.92e-2)" "unprognostic (4.31e-2)" 3.4 1.6 2.8 12.2 2.7 43.4 3.4 5.0 4.2 2.2 3.4 13.9 12.4 2.8 0.4 10.2 1.3 2.9 5.3 2.9 3.1 2.0 2.4 2.1 28.4 2.5 2.7 1.3 1.1 0.5 1.6 6.7 3.3 1.6 16.9 2.6 3.3 0.7 3.0 5.9 12.6 7.4 2.1 4.9 5.0 207.0 3.5 30.9 1.7 4.1 30.0 5.8 4.1 2.6 276.7 102.5 74.0 78.2 12.5 15.3 46.5 63.1 97.0 135.8 146.9 81.8 136.5 139.9 44.4 96.7 135.9 195.9 114.6 78.3 245.6 169.5 59.3 65.8 69.0 126.8 10.1 86.2 47.6 5.4 4.9 84.3 138.3 44.4 88.4 129.8 36.1 162.2 159.8 186.9 118.1 67.9 27.9 254.7 216.4 72.7 66.6 29.7 70.5 56.9 30.6 42.0 118.7 67.4 52.5 54.6 142.9 69.4 33.0 59.2 195.8 91.7 155.0 38.6 47.4 91.4 98.6 120.4 110.9 0.0 1.3 1.3 1.6 1.7 0.7 2.1 5.5 4.8 1.8 0.9 2.9 2.3 1.0 6.4 1.2 1.5 18.8 3.1 2.8 2.7 5.0 4.2 2.9 3.1 2.5 2.7 3.3 2.1 3.5 2.6 1.4 0.0 0.0 0.7 10.5 9.3 4.3 9.7 4.6 3.2 6.4 11.6 9.7 0.0 2.4 1.8 2.1 42.6 2.7 7.3 0.0 3.5 2630.9 2.7 3.5 6.8 7.8 125.5 2.5 2.4 35.0 10.2 9.2 3.5 7.0 31.3 6.1 3.1 37.7 5.0 3.9 17.9 4.1 9.8 8.8 659.4 21.5 8.9 1.8 1.0 2.9 1.7 0.0 0.0 0.2 1.9 7.2 10.5 41.0 4.0 3.4 2.8 0.2 2.9 0.0 3.0 20.5 606.9 39.8 22.5 6.5 4.1 8.3 3.9 31.2 5.3 CHMP4A "C14orf123, HSPC134, VPS32A" ENSG00000254505 "Charged multivesicular body protein 4A" Q9BY43 14 24209615-24213830 "Metabolic proteins, Predicted intracellular proteins" "Protein transport, Transport" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA068473 Approved NA NA 1400000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 63: NK-cells & T-cells - Immune response" "HPA068473: AB_2685994" "unprognostic (4.33e-3)" "unprognostic (3.76e-2)" "unprognostic (4.29e-2)" "unprognostic (5.45e-2)" "unprognostic (4.29e-1)" "unprognostic (1.25e-1)" "unprognostic (1.74e-4)" "unprognostic (2.02e-3)" "unprognostic (9.61e-2)" "unprognostic (1.76e-2)" "unprognostic (1.44e-2)" "unprognostic (1.57e-1)" "prognostic unfavorable (3.91e-8)" "unprognostic (3.30e-1)" "unprognostic (3.42e-1)" "unprognostic (7.37e-2)" "unprognostic (6.90e-2)" 58.8 39.5 73.9 49.3 77.3 38.5 51.4 74.2 109.3 39.1 68.5 59.2 39.4 33.6 79.0 50.5 45.2 35.8 46.9 71.2 73.4 52.4 53.5 36.1 72.6 76.6 75.6 30.8 42.5 72.9 23.0 33.9 76.5 51.0 64.5 15.5 31.5 60.6 20.1 51.6 43.6 51.6 76.8 51.5 45.8 16.5 78.1 70.4 43.4 27.4 84.9 47.7 32.0 77.7 48.7 100.5 43.8 49.1 75.4 67.9 59.7 52.9 62.6 53.0 60.7 46.6 114.9 79.0 48.5 80.6 49.8 56.4 47.5 84.7 58.8 142.6 25.6 64.7 91.6 207.4 131.8 101.1 69.9 69.1 121.6 43.9 168.4 60.8 72.3 84.6 68.2 119.7 107.1 136.1 98.0 93.5 29.0 123.3 83.0 71.9 37.5 86.7 99.3 128.4 28.4 34.3 112.7 101.8 73.8 49.8 65.7 90.2 49.4 33.0 40.0 42.7 47.2 117.1 133.2 86.4 31.2 71.7 71.3 144.3 152.2 103.4 123.4 195.6 132.9 182.8 131.8 138.5 179.9 169.3 101.6 109.9 42.6 138.4 193.6 190.0 185.2 171.6 73.9 77.3 74.2 109.3 71.2 73.4 76.6 75.6 76.5 76.8 78.1 77.7 74.2 16.0 33.3 13.4 78.6 52.6 76.0 154.8 18.8 31.8 66.7 65.7 2.1 92.9 86.3 62.5 64.6 93.4 111.4 50.0 97.8 116.0 11.0 49.1 52.5 58.8 39.2 53.7 14.3 82.3 84.0 39.3 25.5 53.2 76.5 41.1 67.5 73.1 162.5 25.2 12.6 69.9 99.7 94.8 90.3 19.1 66.8 80.1 69.4 11.2 202.6 64.7 178.2 12.1 15.5 76.0 66.7 48.5 44.8 76.1 144.9 159.3 72.2 24.2 98.6 40.6 58.1 20.4 18.3 32.3 78.8 120.7 102.8 43.8 79.7 70.4 CLK1 ENSG00000013441 "CDC like kinase 1" P49759 2 200853009-200864744 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033141, HPA062405" Approved Supported "Nucleoplasm,Nuclear membrane" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 2: Karpas-707 - Immune response" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Nuclear membrane" "CAB033141: AB_1121713, HPA062405: AB_2684753" "unprognostic (9.79e-2)" "unprognostic (2.05e-1)" "unprognostic (2.15e-2)" "unprognostic (1.63e-1)" "unprognostic (9.19e-2)" "unprognostic (4.50e-3)" "unprognostic (1.52e-1)" "unprognostic (2.77e-3)" "unprognostic (1.78e-2)" "unprognostic (2.09e-2)" "unprognostic (1.09e-2)" "unprognostic (5.63e-3)" "unprognostic (2.03e-3)" "unprognostic (9.66e-2)" "unprognostic (2.30e-1)" "unprognostic (1.18e-1)" "prognostic favorable (2.28e-4)" 89.6 82.7 132.9 25.4 137.1 178.0 72.2 140.9 201.6 118.5 136.2 78.3 20.8 65.8 51.1 58.5 85.5 56.5 83.9 133.9 137.7 83.3 84.4 90.3 55.9 138.1 133.4 140.3 63.6 29.0 82.3 64.8 138.6 109.7 24.2 133.8 68.9 49.6 80.4 62.5 51.6 30.9 135.2 113.0 53.2 28.1 134.1 76.0 92.5 71.4 42.0 77.8 112.8 176.0 17.9 13.5 22.6 6.5 24.4 26.1 17.1 19.2 26.8 19.3 25.5 24.6 11.8 5.5 13.1 11.4 11.1 19.7 27.9 8.8 38.2 27.3 24.0 18.1 35.9 30.7 14.7 19.5 31.1 12.3 39.9 23.4 41.8 20.6 11.4 9.5 23.3 77.1 27.0 12.3 23.0 58.4 13.9 11.4 29.8 24.8 25.7 31.8 13.0 11.2 22.0 17.8 16.4 6.1 32.7 12.9 5.3 13.2 19.5 21.4 14.8 21.5 22.0 46.8 20.9 13.7 14.2 15.4 14.9 40.0 7.2 18.6 14.5 5.0 17.3 17.4 15.7 15.8 4.8 11.7 15.6 12.9 16.9 9.5 6.0 11.1 17.2 10.4 132.9 137.1 140.9 201.6 133.9 137.7 138.1 133.4 138.6 135.2 134.1 176.0 122.1 44.8 85.4 112.0 164.2 168.8 263.0 73.6 114.4 59.0 112.9 97.0 96.6 41.5 87.1 27.6 100.1 46.7 213.5 110.9 19.6 31.4 2.3 111.2 108.8 113.6 134.3 87.5 51.7 26.9 56.6 142.5 81.1 173.6 136.9 77.9 82.1 43.3 58.5 52.2 53.6 124.2 50.8 100.5 285.8 9.4 92.9 192.3 154.7 62.8 56.2 54.6 76.2 58.3 169.0 32.0 117.7 75.6 169.0 133.3 88.2 14.9 70.1 99.6 111.7 97.8 128.4 33.1 27.7 117.0 151.7 90.3 261.2 43.0 88.6 184.2 CLK2 ENSG00000176444 "CDC like kinase 2" P49760 1 155262868-155278491 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA055366, HPA059507" Approved Enhanced "Nucleoplasm,Nuclear bodies" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 29: U-266 - Adaptive immune response" "Cluster 43: Cardiomyocytes - Nuclear processes" Nucleoplasm "Nuclear bodies" "HPA055366: AB_2682795, HPA059507: AB_2684044" "unprognostic (2.00e-2)" "unprognostic (1.35e-2)" "prognostic unfavorable (3.77e-4)" "unprognostic (2.84e-2)" "unprognostic (3.16e-1)" "unprognostic (1.75e-1)" "prognostic unfavorable (2.82e-4)" "unprognostic (2.38e-1)" "unprognostic (2.36e-1)" "unprognostic (1.36e-2)" "unprognostic (7.66e-2)" "unprognostic (3.84e-2)" "prognostic unfavorable (2.95e-9)" "unprognostic (1.70e-1)" "unprognostic (1.40e-1)" "unprognostic (1.11e-1)" "prognostic favorable (5.43e-4)" 23.7 25.6 11.6 10.7 11.9 11.4 24.4 14.2 14.4 39.2 14.1 24.1 11.7 29.8 12.7 22.6 28.7 9.6 18.5 11.7 12.7 26.8 29.0 22.0 19.6 12.3 11.7 33.9 23.9 14.0 31.4 13.8 12.4 33.1 8.7 9.4 23.3 11.2 16.2 27.5 24.0 10.9 11.7 40.1 20.8 16.2 12.4 18.6 33.2 8.5 15.9 28.1 29.9 13.2 10.8 10.5 29.8 11.4 17.3 9.1 22.5 8.1 12.3 8.2 7.8 13.1 8.7 23.3 9.7 6.6 4.0 17.0 16.8 13.5 6.3 11.4 17.7 20.4 12.9 15.4 14.6 26.8 20.5 7.6 10.7 11.3 20.3 19.0 13.6 16.9 29.6 15.4 10.5 22.2 12.1 11.3 21.2 27.2 17.6 17.7 21.6 28.0 17.9 25.8 11.8 25.1 4.5 10.9 9.9 21.4 15.9 24.9 9.3 4.3 12.1 9.1 9.1 31.6 28.6 22.9 9.9 19.1 5.9 0.5 0.8 1.9 0.8 0.4 1.6 1.2 1.5 0.8 0.9 0.9 1.6 1.6 0.8 0.5 0.4 0.8 0.9 0.6 11.6 11.9 14.2 14.4 11.7 12.7 12.3 11.7 12.4 11.7 12.4 13.2 9.2 16.0 24.3 9.8 13.7 4.6 5.7 4.2 17.6 5.7 7.8 7.5 14.9 12.8 12.6 7.3 4.2 8.0 7.1 5.4 0.0 6.5 6.5 6.9 15.2 11.1 6.7 8.4 8.3 4.4 8.0 11.3 25.0 9.5 10.1 12.1 7.5 8.4 6.9 5.0 6.8 9.1 2.0 11.4 4.5 6.6 7.8 10.4 3.6 9.4 9.5 5.4 8.2 9.5 8.0 4.9 4.8 3.0 17.1 5.7 5.1 3.2 5.1 7.2 6.6 6.4 12.6 8.6 4.3 14.3 4.5 12.4 11.0 7.4 7.2 5.1 CLK3 ENSG00000179335 "CDC like kinase 3" P49761 15 74598500-74645414 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046817 Approved Supported "Nucleoplasm,Intermediate filaments" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 30: Epithelial cell lines - Translation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "Intermediate filaments" "HPA046817: AB_10964124" "unprognostic (4.10e-2)" "unprognostic (8.43e-2)" "prognostic unfavorable (2.05e-6)" "unprognostic (1.91e-3)" "unprognostic (7.91e-2)" "unprognostic (5.76e-2)" "unprognostic (1.46e-1)" "unprognostic (1.30e-2)" "unprognostic (1.95e-1)" "unprognostic (2.54e-1)" "unprognostic (8.14e-3)" "prognostic unfavorable (5.92e-4)" "unprognostic (1.35e-2)" "unprognostic (2.24e-1)" "unprognostic (9.73e-2)" "unprognostic (2.48e-1)" "unprognostic (2.25e-2)" 35.9 28.7 30.3 26.5 31.8 112.4 34.6 36.4 35.9 36.7 32.8 36.6 28.9 32.3 25.9 38.6 31.3 32.7 28.3 30.2 31.2 30.0 29.4 34.0 37.7 32.8 31.6 38.4 33.9 35.3 32.3 31.6 32.5 31.9 21.8 33.1 36.1 29.7 50.7 41.7 33.7 26.2 29.5 41.7 35.1 44.4 32.2 55.8 32.3 52.1 30.3 37.8 33.8 35.4 56.7 35.1 45.5 25.6 57.2 43.4 35.8 37.7 59.2 52.7 64.3 47.9 36.4 51.2 27.2 33.9 73.5 39.0 85.4 36.3 34.3 73.2 46.9 63.0 52.0 33.6 90.7 17.2 46.6 54.8 71.0 69.4 57.4 64.0 58.6 51.0 31.3 36.2 31.1 39.9 50.9 57.3 29.1 55.7 24.6 40.7 21.8 33.7 41.1 40.3 25.5 29.9 30.2 33.0 34.3 34.7 31.4 33.8 27.3 31.0 23.7 19.7 50.2 59.0 51.8 42.2 27.2 82.4 40.1 74.2 65.5 90.0 68.9 74.1 68.2 71.0 73.6 71.9 61.3 78.8 74.4 70.9 115.9 90.7 97.7 69.5 87.7 85.9 30.3 31.8 36.4 35.9 30.2 31.2 32.8 31.6 32.5 29.5 32.2 35.4 29.8 6.4 38.4 14.0 34.1 44.9 44.9 41.6 26.2 35.5 22.8 15.9 18.6 28.6 35.1 12.9 56.3 27.7 41.8 46.7 31.3 34.2 83.6 25.8 19.9 28.6 29.3 31.5 6.6 24.2 46.2 24.5 37.8 41.5 21.5 27.4 21.4 13.4 27.5 28.6 7.9 34.7 42.7 23.3 34.4 19.8 27.7 28.4 28.4 6.5 29.5 18.0 29.9 7.1 9.6 30.8 52.0 20.3 26.6 38.9 35.5 18.6 23.4 42.6 13.1 20.4 35.8 45.4 21.4 21.0 41.9 58.6 40.1 20.4 28.1 63.5 CLK4 ENSG00000113240 "CDC like kinase 4" Q9HAZ1 5 178602664-178630615 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 5 "Early spermatids: 297.5;Late spermatids: 518.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043746 Approved Approved "Actin filaments" No No "Cluster 5: Granulocytes - Unknown function" "Cluster 54: Non-specific - Microtubule organization" "Cluster 20: HeLa - Mitochondria" "Cluster 34: Spermatids - Unknown function" "Actin filaments" "HPA043746: AB_2678650" "unprognostic (9.46e-2)" "unprognostic (2.24e-2)" "unprognostic (1.48e-1)" "unprognostic (3.44e-2)" "unprognostic (1.59e-1)" "unprognostic (7.16e-3)" "unprognostic (2.67e-1)" "unprognostic (2.04e-2)" "unprognostic (4.37e-2)" "unprognostic (5.92e-2)" "unprognostic (2.90e-3)" "unprognostic (9.62e-3)" "unprognostic (1.13e-2)" "unprognostic (1.26e-1)" "unprognostic (3.38e-1)" "unprognostic (1.20e-1)" "unprognostic (1.14e-3)" 13.8 11.9 14.0 7.8 14.9 10.4 13.6 22.9 20.1 20.1 14.0 14.4 9.4 12.8 11.9 10.1 13.7 9.8 13.0 14.1 14.5 13.4 13.7 10.8 17.6 15.0 14.0 18.3 17.6 7.9 10.3 10.8 15.2 16.7 6.6 34.4 13.0 8.3 17.8 15.1 12.6 5.5 14.0 18.6 12.5 15.2 14.2 16.6 16.6 21.1 10.0 12.5 21.0 19.3 8.1 7.2 6.8 10.0 19.9 15.9 11.2 7.6 8.8 4.5 8.4 7.7 6.6 4.6 6.0 3.2 5.2 10.4 8.9 6.0 7.5 16.8 6.8 1.8 15.2 8.8 7.4 3.8 5.7 7.2 8.8 7.6 9.6 15.1 3.2 3.1 4.1 13.4 5.5 3.3 5.2 13.8 3.4 5.4 4.5 4.8 6.0 6.7 4.2 2.3 7.4 5.0 8.4 4.7 8.4 3.8 5.1 8.0 6.9 9.5 3.4 4.9 8.4 8.4 3.5 3.5 6.8 9.0 5.0 7.7 5.9 12.7 8.9 4.1 12.6 12.8 9.5 8.4 5.9 10.2 12.2 9.5 16.1 8.4 4.3 7.4 9.6 4.9 14.0 14.9 22.9 20.1 14.1 14.5 15.0 14.0 15.2 14.0 14.2 19.3 31.9 16.0 27.8 45.7 57.8 31.9 44.5 18.4 40.9 70.8 23.5 21.6 22.9 11.5 23.7 14.7 39.6 20.1 52.1 12.2 5.9 9.4 297.5 22.8 30.1 25.4 6.0 38.7 79.6 4.7 18.4 29.2 20.4 19.8 27.9 36.1 18.9 13.0 10.1 28.6 40.5 10.7 14.2 13.9 24.7 518.3 30.7 21.4 16.0 43.1 18.3 29.6 27.8 61.9 60.6 7.2 16.5 29.3 36.5 23.9 25.0 10.1 26.8 81.3 19.7 17.1 30.9 30.3 18.4 19.7 24.6 15.9 42.0 24.1 10.2 26.9 CSF1R "C-FMS, CD115, CSFR, FMS" ENSG00000182578 "Colony stimulating factor 1 receptor" P07333 5 150053291-150113372 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Immunity, Inflammatory response, Innate immunity" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Neurodegeneration, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 113.3;placenta: 103.3" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 103.2;Hofbauer cells: 340.4;Kupffer cells: 291.2;Langerhans cells: 73.4;Macrophages: 196.3;Microglial cells: 134.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "intermediate monocyte: 444.6;non-classical monocyte: 646.9" "Lineage enriched" "Detected in many" 5 "monocytes: 646.9" "Group enriched" "Detected in some" 4 "BEWO: 123.0;SK-BR-3: 47.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008970, HPA012323" Uncertain Supported "Vesicles,Plasma membrane" "Intracellular and membrane" NA NA 1600000000 "Cluster 51: Monocytes - Innate immune response" "Cluster 64: Macrophages - Immune response" "Cluster 28: BEWO - Transcription regulation" "Cluster 4: Macrophages - Innate immune response" "Vesicles, Plasma membrane" "CAB008970: , HPA012323: AB_1848977" "unprognostic (3.82e-2)" "unprognostic (1.31e-1)" "unprognostic (1.86e-3)" "unprognostic (9.83e-2)" "unprognostic (1.20e-1)" "unprognostic (7.33e-2)" "unprognostic (1.03e-1)" "unprognostic (1.45e-1)" "unprognostic (9.37e-2)" "unprognostic (1.11e-2)" "unprognostic (2.49e-1)" "unprognostic (1.65e-1)" "prognostic unfavorable (1.08e-4)" "unprognostic (3.67e-2)" "prognostic unfavorable (4.92e-4)" "unprognostic (1.72e-2)" "unprognostic (4.61e-2)" 51.3 31.0 19.6 75.1 17.1 5.6 19.3 20.2 21.4 21.6 19.3 21.9 24.3 12.1 5.8 21.0 17.2 40.6 16.6 19.8 33.8 7.1 27.5 36.6 54.4 41.4 35.5 12.7 9.9 11.8 5.7 103.3 40.1 9.1 21.5 1.5 10.1 20.8 3.2 13.4 37.3 41.9 36.6 113.3 21.0 7.0 40.6 14.3 6.0 11.8 21.7 42.6 3.8 67.6 4.5 0.2 0.0 0.0 1.9 0.4 123.0 0.2 0.2 0.0 0.0 3.8 0.0 5.9 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.1 0.1 0.1 0.2 1.1 3.0 0.0 6.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 6.1 0.1 0.0 0.0 0.0 1.9 0.6 0.0 0.0 0.2 0.2 0.0 47.8 0.0 1.9 0.0 20.7 0.0 0.8 0.2 0.1 3.3 0.0 0.3 0.1 6.6 2.6 0.0 3.0 138.4 4.0 0.6 444.6 0.6 0.3 0.2 0.4 139.0 0.2 0.3 0.2 21.6 0.2 646.9 11.1 0.5 132.7 19.6 17.1 20.2 21.4 19.8 33.8 41.4 35.5 40.1 36.6 40.6 67.6 2.0 0.0 3.8 0.0 4.3 2.8 0.0 0.0 1.2 0.0 0.5 2.3 3.1 4.3 0.0 0.0 0.0 6.2 2.8 0.0 0.0 0.0 4.8 0.0 0.1 10.5 0.0 2.5 0.4 0.0 103.2 2.2 1.5 0.2 2.5 8.3 2.9 1.5 340.4 0.0 0.5 0.3 0.0 291.2 73.4 5.4 1.8 196.3 3.6 134.9 39.4 0.0 1.0 1.5 0.3 0.1 1.7 0.0 1.0 0.0 0.0 0.1 0.7 0.5 13.1 1.2 2.0 2.2 0.2 0.4 1.3 26.4 1.3 2.2 0.2 0.0 CSK ENSG00000103653 "C-terminal Src kinase" P41240 15 74782057-74803198 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Adaptive immunity, Immunity" "Kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 169.3" "Cell type enhanced" "Detected in all" "B-cells: 130.9;dendritic cells: 99.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011203, HPA026488, HPA028425" Approved Approved Enhanced Vesicles,Cytosol No No 150000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 16: Immune cells - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 57: B-cells - Immune response" "Vesicles, Cytosol" "CAB011203: AB_259070, HPA026488: AB_1847273, HPA028425: AB_10600899" "unprognostic (1.05e-1)" "prognostic favorable (5.14e-5)" "unprognostic (2.59e-3)" "prognostic favorable (8.22e-4)" "unprognostic (4.15e-2)" "unprognostic (4.11e-2)" "unprognostic (1.87e-1)" "unprognostic (2.96e-1)" "unprognostic (2.20e-1)" "unprognostic (1.31e-1)" "unprognostic (4.12e-2)" "unprognostic (4.61e-2)" "prognostic unfavorable (1.74e-4)" "prognostic favorable (1.07e-4)" "unprognostic (1.44e-1)" "unprognostic (1.01e-1)" "unprognostic (6.29e-2)" 21.4 19.9 23.4 89.1 26.2 50.6 19.4 26.5 26.7 26.8 18.2 33.6 36.7 22.4 8.0 98.5 20.0 22.9 29.3 22.5 23.9 21.3 48.8 32.0 169.3 31.0 29.8 19.0 17.2 15.8 21.1 17.6 31.6 24.8 19.5 6.9 31.6 14.1 14.8 36.7 59.9 18.7 29.1 127.9 30.0 19.2 28.2 68.5 19.5 15.8 106.3 33.0 32.8 28.4 62.2 85.6 41.2 68.1 38.5 29.2 35.3 40.7 38.8 75.7 53.6 78.9 56.0 275.7 52.6 37.0 70.2 62.9 87.2 82.1 21.2 134.7 107.8 233.8 29.5 80.2 53.3 123.6 285.1 41.7 39.6 54.0 48.1 37.9 58.1 127.5 68.7 93.1 45.7 104.6 89.7 72.7 51.2 55.7 60.6 98.0 35.4 201.9 34.9 135.6 68.1 47.2 52.8 109.5 72.3 26.2 75.5 179.5 50.7 91.1 47.8 72.5 71.7 49.6 108.7 283.8 47.1 232.5 63.1 88.7 68.0 176.1 74.3 146.8 63.4 95.6 63.6 73.9 76.6 113.6 48.3 57.0 130.8 58.6 169.8 44.3 106.2 79.5 23.4 26.2 26.5 26.7 22.5 23.9 31.0 29.8 31.6 29.1 28.2 28.4 21.3 3.2 9.2 8.5 130.9 9.3 8.2 7.6 13.1 16.6 16.7 17.1 11.5 12.8 9.3 9.2 6.2 7.5 99.1 40.6 1.9 9.3 15.8 10.0 15.1 15.3 9.5 29.2 5.3 14.0 13.7 11.3 27.0 15.3 26.6 19.0 12.5 34.3 50.7 28.6 10.0 23.2 6.1 91.2 44.9 3.3 9.0 85.1 8.8 23.4 86.9 6.4 90.6 3.5 4.7 21.2 18.4 8.2 56.7 13.9 27.5 8.0 9.3 5.1 6.6 6.9 18.1 5.7 12.5 49.4 9.1 5.6 90.3 21.5 27.5 14.9 DDR1 "CAK, CD167, EDDR1, NEP, NTRK4, PTK3A, RTK6" ENSG00000204580 "Discoidin domain receptor tyrosine kinase 1" Q08345 6 30876421-30900156 "CD markers, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lactation, Pregnancy" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HaCaT: 90.9;HBEC3-KT: 70.1;RT4: 93.5;T-47d: 103.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010162, CAB025656, HPA057194" Approved Approved "Nucleoplasm,Cell Junctions" "Intracellular and membrane" NA NA 4400000 "Cluster 30: Non-specific - Translation" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 15: RT4 - Unknown function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Nucleoplasm, Cell Junctions" "CAB010162: AB_2092090, CAB025656: , HPA057194: " "unprognostic (2.11e-2)" "unprognostic (9.31e-2)" "unprognostic (1.01e-1)" "unprognostic (1.09e-1)" "unprognostic (2.07e-1)" "unprognostic (7.75e-3)" "unprognostic (6.43e-2)" "unprognostic (1.92e-1)" "unprognostic (1.73e-1)" "unprognostic (1.42e-1)" "unprognostic (1.50e-1)" "unprognostic (4.41e-2)" "prognostic favorable (3.31e-10)" "unprognostic (1.42e-1)" "unprognostic (2.53e-1)" "unprognostic (5.49e-3)" "unprognostic (4.09e-2)" 26.5 50.4 24.1 5.3 49.5 0.4 54.6 47.9 20.2 55.2 4.8 57.7 12.3 23.4 4.5 150.1 46.2 11.4 42.1 17.5 40.7 96.8 6.3 33.7 1.2 68.7 47.3 41.5 99.7 19.7 67.9 4.2 57.9 70.2 10.7 4.5 131.7 13.8 40.5 121.1 47.3 1.1 38.8 11.5 71.1 16.5 46.3 7.0 85.9 4.3 3.0 45.0 88.4 58.9 58.2 18.5 26.0 5.4 1.7 2.4 16.2 1.4 0.4 0.8 0.1 25.2 29.8 0.5 30.9 5.1 26.8 90.9 5.7 70.1 0.3 32.0 9.9 0.2 18.7 6.7 5.0 0.0 1.2 3.3 35.4 0.4 0.5 16.1 2.0 1.4 17.3 0.7 4.0 36.5 2.0 0.1 4.5 31.8 3.8 3.9 19.5 2.2 13.1 93.5 4.7 2.5 5.4 41.4 19.4 8.6 103.0 0.6 4.3 12.8 11.7 1.2 13.6 0.8 0.1 2.6 8.4 0.0 11.2 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.1 0.0 0.2 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.2 24.1 49.5 47.9 20.2 17.5 40.7 68.7 47.3 57.9 38.8 46.3 58.9 1.9 35.3 24.6 54.5 3.8 53.0 68.3 125.5 67.2 7.4 77.0 57.9 18.0 37.1 79.8 90.1 0.0 63.6 1.5 109.7 5.9 125.5 15.1 58.5 6.5 4.1 46.2 2.7 1.2 76.2 26.0 7.4 63.7 58.4 1.3 29.5 2.2 0.6 6.1 6.7 7.5 69.8 109.9 0.8 5.4 30.1 8.4 2.5 16.0 9.4 13.1 139.9 1.0 60.3 73.8 71.5 78.2 5.3 0.8 68.1 77.3 5.4 104.2 8.0 6.6 10.5 11.9 1.5 6.8 81.8 51.9 46.5 1.9 4.1 67.1 88.4 DDR2 "NTRKR3, TKT, TYRO10" ENSG00000162733 "Discoidin domain receptor tyrosine kinase 2" Q16832 1 162631373-162787405 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Osteogenesis "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, Dwarfism, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 89.8;Fibroblasts: 116.5;Leydig cells: 63.0;Peritubular cells: 88.4;Skeletal myocytes: 98.2;Smooth muscle cells: 78.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 233.3;ASC TERT1: 214.4;BJ hTERT+: 163.4;fHDF/TERT166: 137.6;HSkMC: 157.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA070112 Approved "Plasma membrane,Actin filaments" Yes No 770000 "Cluster 57: Non-specific - Angiogenesis" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane, Actin filaments" "HPA070112: AB_2686229" "unprognostic (4.12e-2)" "unprognostic (2.73e-1)" "unprognostic (6.97e-3)" "unprognostic (4.52e-2)" "unprognostic (1.17e-1)" "unprognostic (8.16e-2)" "unprognostic (1.81e-1)" "unprognostic (1.19e-1)" "unprognostic (6.62e-2)" "unprognostic (2.24e-2)" "unprognostic (1.00e-1)" "unprognostic (1.15e-1)" "prognostic unfavorable (1.73e-7)" "unprognostic (1.56e-3)" "unprognostic (8.26e-3)" "unprognostic (7.57e-2)" "unprognostic (4.10e-3)" 59.8 64.3 13.2 15.8 11.3 0.3 25.2 10.4 9.2 33.7 51.5 54.7 5.8 26.2 13.2 18.1 22.4 23.8 24.1 12.6 24.5 6.4 5.4 14.5 9.1 37.0 22.1 37.4 3.7 2.5 5.4 10.6 31.7 17.3 14.1 5.1 9.8 29.2 4.9 9.7 17.6 42.8 17.8 5.8 20.4 3.9 21.0 3.3 12.9 19.3 6.9 23.2 23.6 25.2 0.3 0.0 0.2 63.2 233.3 214.4 1.0 92.2 163.4 41.5 56.8 0.0 0.2 0.0 0.1 137.6 8.9 0.1 0.3 0.4 54.0 42.9 0.3 0.0 0.4 0.1 103.9 0.2 0.2 157.0 0.4 73.1 2.2 65.8 46.0 0.4 0.6 16.8 36.9 0.1 0.0 0.3 0.4 0.1 0.3 0.1 24.1 0.7 0.2 0.2 0.3 35.4 0.2 0.1 2.9 3.6 0.2 0.3 2.1 58.5 13.8 29.1 12.6 2.6 4.0 0.1 56.3 0.1 62.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.2 11.3 10.4 9.2 12.6 24.5 37.0 22.1 31.7 17.8 21.0 25.2 23.4 3.2 2.3 53.2 2.5 12.6 3.9 0.8 1.2 3.0 6.0 15.6 31.3 1.5 1.1 0.0 0.0 0.5 1.7 3.2 0.0 0.4 8.9 5.0 89.8 22.3 1.2 0.0 13.1 1.8 0.5 116.5 2.6 8.2 1.3 16.7 30.0 3.5 1.2 0.0 26.2 1.0 0.0 1.9 19.3 7.1 63.0 3.1 23.2 29.0 0.0 16.5 2.1 6.0 5.6 1.8 4.4 88.4 5.6 5.9 1.2 2.1 2.4 3.0 39.5 98.2 78.3 1.0 0.9 2.0 8.7 1.0 2.5 34.2 0.8 4.2 DNAJC6 "KIAA0473, PARK19" ENSG00000116675 "DnaJ heat shock protein family (Hsp40) member C6" O75061 1 65248219-65415871 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Chaperone, Hydrolase, Protein phosphatase" "Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 81.5;retina: 52.8" "Cell type enriched" "Detected in many" 4 "Oligodendrocytes: 1038.1" "Cancer enriched" "Detected in many" 4 "glioma: 5.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HDLM-2: 62.1;HEL: 165.8;K-562: 65.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031182, HPA054917" Enhanced Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 77: Retina - Visual perception" "Cluster 36: HEL - Hemostasis" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "Nucleoplasm, Plasma membrane" "HPA031182: AB_10611957, HPA054917: AB_2682641" "unprognostic (6.99e-2)" "unprognostic (2.00e-3)" "unprognostic (3.19e-1)" "unprognostic (7.94e-7)" "unprognostic (1.59e-1)" "unprognostic (7.61e-3)" "unprognostic (1.87e-4)" "unprognostic (2.98e-1)" "unprognostic (1.89e-1)" "unprognostic (4.14e-1)" "unprognostic (4.22e-3)" "unprognostic (1.53e-1)" "prognostic favorable (2.81e-4)" "unprognostic (1.43e-2)" "unprognostic (1.12e-1)" "unprognostic (1.36e-1)" "unprognostic (8.67e-3)" 1.5 11.1 34.7 0.9 43.3 4.7 1.1 33.7 46.9 0.8 0.0 2.1 1.0 0.6 0.4 0.3 1.1 1.0 8.9 42.1 48.0 7.7 0.4 1.5 0.2 60.2 51.3 0.5 2.1 1.0 12.6 7.4 67.6 1.1 1.7 52.8 0.7 0.7 0.4 1.1 1.0 0.9 27.2 2.1 1.7 2.2 42.0 0.8 1.7 0.8 0.3 1.1 0.9 81.5 10.4 2.8 0.1 4.4 2.1 0.5 23.4 20.1 33.1 32.6 31.7 2.7 0.5 9.9 1.7 8.3 8.0 2.5 14.6 3.3 25.8 62.1 6.9 165.8 5.1 0.6 0.2 5.6 3.9 2.7 2.2 3.3 13.8 6.0 0.7 8.0 65.5 1.2 6.6 1.9 2.1 0.0 6.5 0.0 2.2 0.0 4.9 0.4 23.7 0.0 39.4 27.0 11.9 15.5 5.4 37.4 7.5 0.3 6.5 4.8 3.3 0.6 5.9 6.0 4.1 3.0 13.4 4.1 8.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 34.7 43.3 33.7 46.9 42.1 48.0 60.2 51.3 67.6 27.2 42.0 81.5 0.8 0.0 0.5 49.3 0.5 1.3 0.4 0.5 0.0 30.4 0.6 0.3 28.0 2.8 0.2 0.0 14.6 8.9 1.5 0.4 1.9 0.8 2.0 1.8 0.5 3.7 7.2 19.4 237.4 0.7 2.1 5.8 1.5 3.0 0.0 0.6 0.4 0.1 1.2 52.2 237.6 1.9 2.0 0.0 0.8 1.9 0.0 0.7 7.2 18.7 1.1 4.1 0.0 136.7 1038.1 0.4 0.2 0.0 0.9 1.7 0.0 7.2 1.2 21.6 0.0 0.2 8.5 1.7 2.5 0.0 0.3 7.4 0.6 6.9 0.6 0.2 DUSP1 "CL100, HVH1, MKP-1, PTPN10" ENSG00000120129 "Dual specificity phosphatase 1" P28562 5 172768096-172771195 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Stress response" "Hydrolase, Protein phosphatase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Langerhans cells: 2357.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 5 "neutrophil: 7426.8" "Lineage enriched" "Detected in all" 9 "granulocytes: 7426.8" "Cell line enhanced" "Detected in all" "HHSteC: 201.0;hTCEpi: 359.3;REH: 202.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA069577 Approved Nucleoli,Cytosol NA Yes "Cluster 50: Neutrophils - Cellular senescence" "Cluster 31: Skin - Epidermis development" "Cluster 30: Epithelial cell lines - Translation" "Cluster 41: Macrophages - Immune response" Nucleoli Cytosol "HPA069577: AB_2686156" "unprognostic (1.51e-1)" "unprognostic (1.24e-1)" "unprognostic (9.73e-2)" "unprognostic (8.17e-2)" "unprognostic (4.64e-1)" "unprognostic (1.58e-3)" "unprognostic (4.18e-2)" "unprognostic (6.94e-2)" "unprognostic (3.11e-1)" "unprognostic (1.43e-2)" "unprognostic (2.23e-1)" "unprognostic (1.51e-2)" "unprognostic (2.76e-2)" "prognostic unfavorable (3.11e-5)" "unprognostic (2.69e-1)" "unprognostic (2.35e-2)" "unprognostic (1.41e-3)" 922.6 515.4 84.9 364.9 85.8 692.4 586.1 134.8 121.1 501.3 134.7 336.1 66.0 382.3 42.0 526.6 677.4 570.5 395.3 79.4 114.6 281.2 721.3 719.9 178.6 132.0 90.3 541.2 240.1 116.5 319.5 297.3 104.1 438.5 228.5 202.7 350.3 356.9 251.8 1054.1 170.3 452.7 123.7 304.7 396.0 68.1 115.4 131.3 612.9 451.3 56.2 778.1 610.0 121.2 10.7 26.5 8.2 11.5 175.6 102.2 14.0 170.3 49.3 111.9 45.0 29.2 12.4 3.5 48.6 120.4 128.1 4.7 8.1 42.3 52.1 95.8 22.4 2.3 63.1 12.6 201.0 1.2 3.8 98.1 359.3 50.9 82.1 58.2 35.6 7.4 9.0 66.1 73.1 12.6 5.7 5.0 7.4 8.2 7.7 202.2 15.3 32.3 80.2 5.4 35.5 14.9 46.2 76.9 6.3 34.1 6.7 1.9 94.1 79.1 39.8 77.8 13.4 13.6 8.4 3.1 70.3 1.8 3.3 931.4 584.5 1640.7 85.0 589.2 212.6 57.6 75.6 88.6 263.4 54.1 35.9 40.7 7426.8 114.5 791.6 14.3 68.1 409.9 84.9 85.8 134.8 121.1 79.4 114.6 132.0 90.3 104.1 123.7 115.4 121.2 1856.5 410.3 341.0 23.8 918.4 1279.8 1140.5 456.9 1810.4 73.0 464.2 567.7 211.3 739.2 243.1 211.5 27.1 316.2 618.9 633.7 56.7 335.9 71.6 531.6 990.9 870.4 715.5 193.5 11.9 88.7 407.2 1367.4 597.3 1013.7 301.1 175.8 781.4 345.7 1043.0 48.8 13.4 891.8 207.5 1525.5 2357.3 40.3 384.9 1965.5 542.5 66.5 173.3 1159.3 33.0 6.6 4.1 226.3 683.3 311.1 952.2 685.7 736.1 35.5 218.0 190.5 769.2 720.7 671.9 12.9 24.6 1996.9 1956.6 582.0 1015.2 223.4 415.8 676.6 DUSP10 "MKP-5, MKP5" ENSG00000143507 "Dual specificity phosphatase 10" Q9Y6W6 1 221701424-221742089 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 32.9" "Cell type enhanced" "Detected in many" "granulocytes: 133.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "NK-cell: 19.7" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HaCaT: 102.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016758 Approved Supported "Nucleoplasm,Golgi apparatus,Cytosol" No No "Cluster 15: NK-cells - Transcription" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 24: Non-specific - Transcription regulation" Nucleoplasm "Golgi apparatus, Cytosol" "HPA016758: AB_1847880" "unprognostic (1.55e-1)" "unprognostic (2.73e-1)" "unprognostic (1.44e-1)" "unprognostic (6.65e-2)" "unprognostic (3.83e-2)" "unprognostic (2.85e-3)" "prognostic favorable (5.42e-4)" "unprognostic (2.89e-1)" "unprognostic (3.89e-2)" "unprognostic (9.68e-2)" "unprognostic (2.38e-2)" "unprognostic (1.05e-1)" "prognostic unfavorable (3.69e-4)" "unprognostic (4.18e-2)" "unprognostic (2.57e-1)" "unprognostic (8.88e-3)" "unprognostic (1.97e-2)" 3.8 2.4 4.3 5.2 7.4 25.0 6.0 7.7 5.3 4.5 4.7 8.0 1.4 3.6 1.2 6.0 6.4 6.6 2.6 4.5 4.5 1.4 32.9 6.2 9.1 7.1 6.0 1.6 17.0 1.2 1.2 3.8 5.8 2.7 4.1 14.9 6.3 0.9 22.9 6.1 3.9 8.9 3.8 6.1 2.5 3.1 9.0 5.6 4.4 3.6 7.6 6.1 2.7 13.5 15.2 6.4 0.5 0.4 45.4 22.6 0.5 10.1 25.9 16.2 12.5 0.3 4.2 11.6 3.3 26.1 11.9 102.3 2.2 9.8 14.0 30.5 1.2 20.4 3.0 1.8 10.6 9.1 13.3 31.9 7.0 17.6 17.8 7.5 0.6 3.0 2.1 4.0 16.0 0.3 1.8 7.2 1.5 3.2 0.7 1.1 28.5 0.9 5.7 9.1 37.4 3.0 1.3 1.2 43.6 5.6 2.1 5.5 3.6 8.1 2.2 12.6 12.4 6.8 5.1 6.2 12.8 4.1 8.9 8.2 5.5 0.3 4.5 4.6 3.9 0.8 2.9 3.1 7.0 0.9 1.0 1.7 0.5 19.7 1.9 0.2 16.9 2.2 4.3 7.4 7.7 5.3 4.5 4.5 7.1 6.0 5.8 3.8 9.0 13.5 4.9 0.0 1.7 2.6 21.7 50.9 13.5 13.6 25.6 6.0 42.4 18.7 4.7 14.3 19.2 3.7 20.9 2.8 39.0 3.1 0.0 35.9 61.1 57.9 6.6 6.7 43.9 2.5 0.3 9.1 3.7 7.9 4.6 53.7 133.5 0.2 1.8 53.6 22.3 1.7 30.9 17.7 69.2 9.7 46.9 7.1 24.8 26.0 23.2 2.8 14.1 14.3 17.5 17.1 50.5 26.2 0.8 12.8 9.9 11.0 0.4 1.1 18.5 34.2 0.0 33.7 5.3 9.7 3.2 16.7 41.3 3.4 47.0 28.7 3.6 16.5 DUSP11 PIR1 ENSG00000144048 "Dual specificity phosphatase 11" O75319 2 73762184-73780157 "Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase, RNA-binding" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021052 Supported "Nucleoplasm,Nucleoli fibrillar center,Cytokinetic bridge" Yes Yes "Cluster 31: Non-specific - Inflammatory response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 30: Epithelial cell lines - Translation" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Nucleoplasm, Nucleoli fibrillar center" "Cytokinetic bridge" "HPA021052: AB_2670577" "unprognostic (2.45e-3)" "unprognostic (1.06e-1)" "unprognostic (2.19e-2)" "unprognostic (7.87e-3)" "unprognostic (9.14e-2)" "unprognostic (5.28e-3)" "prognostic unfavorable (2.10e-7)" "unprognostic (7.20e-2)" "unprognostic (5.43e-2)" "unprognostic (5.85e-2)" "unprognostic (8.67e-3)" "unprognostic (3.84e-2)" "unprognostic (7.56e-3)" "unprognostic (1.41e-1)" "unprognostic (1.47e-1)" "unprognostic (1.47e-3)" "unprognostic (1.46e-1)" 16.0 13.3 7.9 17.1 7.7 35.2 20.4 13.4 11.2 22.4 7.6 16.0 17.3 21.2 19.3 30.5 39.0 15.9 14.2 8.1 6.9 20.2 17.9 14.3 25.3 6.1 5.7 23.5 11.0 14.7 14.0 20.5 6.1 16.5 17.4 8.3 16.0 14.4 14.3 27.6 15.3 19.6 4.8 19.0 16.3 16.8 6.5 24.8 16.5 17.8 26.1 25.2 22.4 8.3 39.4 16.7 17.6 18.6 31.2 38.7 31.2 28.2 36.7 35.8 36.4 24.2 29.1 50.6 17.7 30.6 32.1 26.7 22.0 56.8 34.3 35.2 22.9 31.2 12.0 37.3 32.7 35.5 28.0 31.6 67.3 32.1 44.1 31.1 40.4 24.2 33.6 28.6 40.2 21.3 34.3 37.6 28.4 36.7 22.7 13.6 47.3 46.0 29.3 32.1 25.9 14.1 26.1 30.6 35.7 21.0 16.4 18.6 23.1 25.4 31.4 29.5 33.7 30.7 26.2 68.1 23.5 35.5 25.3 72.5 42.2 99.5 56.3 39.3 73.5 68.3 65.8 67.4 47.3 65.9 69.4 65.5 65.2 69.8 40.6 35.7 88.6 71.7 7.9 7.7 13.4 11.2 8.1 6.9 6.1 5.7 6.1 4.8 6.5 8.3 26.5 9.6 12.0 7.5 39.5 83.2 55.1 93.0 39.3 11.0 12.9 15.1 8.6 27.1 45.7 12.9 4.2 32.8 34.8 15.5 50.9 29.6 9.1 18.0 15.7 34.6 12.0 21.0 14.9 27.3 42.0 26.5 16.3 13.6 40.7 20.5 52.1 15.3 30.7 5.0 12.7 18.0 36.7 20.2 27.1 7.0 28.9 17.0 23.2 10.3 34.8 9.8 41.2 13.0 13.8 28.2 17.8 25.6 31.8 30.0 22.8 50.4 38.2 16.6 6.6 18.2 23.1 23.8 34.6 42.8 83.0 38.6 39.8 20.7 18.8 60.9 DUSP12 "DUSP1, YVH1" ENSG00000081721 "Dual specificity phosphatase 12" Q9UNI6 1 161749758-161757238 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008840 Uncertain Supported Nucleoplasm NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA008840: AB_1847884" "unprognostic (3.51e-2)" "unprognostic (2.62e-1)" "unprognostic (1.05e-1)" "unprognostic (2.01e-2)" "unprognostic (2.11e-1)" "unprognostic (4.04e-2)" "prognostic unfavorable (1.99e-5)" "unprognostic (1.86e-1)" "unprognostic (1.06e-2)" "unprognostic (2.25e-3)" "unprognostic (9.52e-2)" "unprognostic (2.42e-3)" "prognostic unfavorable (1.55e-7)" "unprognostic (1.17e-1)" "unprognostic (1.84e-1)" "unprognostic (3.25e-2)" "unprognostic (2.42e-1)" 13.3 9.6 12.1 9.1 12.5 30.9 14.1 14.3 14.6 13.8 12.1 12.9 7.6 14.3 8.9 10.3 12.5 6.7 9.4 12.0 12.4 14.4 9.4 11.4 13.8 12.2 12.2 13.6 13.6 8.2 9.5 11.2 12.3 11.0 10.5 13.2 10.9 9.5 7.4 10.9 12.4 11.0 12.3 14.1 11.5 6.7 12.0 11.7 12.1 7.3 13.0 13.1 11.5 13.3 32.6 28.2 33.1 21.7 17.2 18.5 30.4 25.9 33.7 39.2 29.9 42.1 28.2 19.9 25.7 31.9 24.4 22.7 26.0 32.0 38.0 25.5 22.0 17.8 27.7 28.4 36.4 38.6 17.1 25.4 34.6 34.1 61.0 22.2 27.6 27.2 31.7 20.9 28.3 30.0 22.7 43.2 52.1 35.2 43.1 32.2 32.0 32.9 22.2 39.3 20.6 43.6 21.9 36.2 44.1 36.2 31.3 43.6 19.3 33.3 30.8 26.3 55.6 35.3 31.0 47.0 20.3 38.1 33.3 32.0 16.9 13.7 18.4 19.5 22.9 19.2 20.8 17.8 22.0 20.0 19.6 21.8 6.8 28.4 12.2 10.0 19.5 12.9 12.1 12.5 14.3 14.6 12.0 12.4 12.2 12.2 12.3 12.3 12.0 13.3 22.9 19.2 12.8 8.1 25.5 13.6 14.4 25.9 25.6 15.9 13.4 16.1 5.0 8.6 15.6 7.3 8.4 21.7 26.4 4.8 21.5 22.2 4.2 7.4 13.7 18.4 11.3 16.2 11.9 24.3 22.7 17.3 11.7 7.2 18.3 18.7 18.5 8.2 20.5 10.1 14.8 9.8 8.2 20.6 16.2 1.2 8.7 15.4 10.6 10.3 22.1 15.8 33.0 12.1 14.4 21.2 6.5 17.7 27.5 17.1 8.6 18.5 7.0 19.6 0.0 13.2 24.5 13.9 12.6 18.2 13.1 17.6 23.5 16.4 12.1 12.0 DUSP13 "BEDP, DUSP13A, DUSP13B, FLJ32450, TMDP" ENSG00000079393 "Dual specificity phosphatase 13" "Q6B8I1, Q9UII6" 10 75094432-75109221 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "skeletal muscle: 247.2;testis: 53.7;tongue: 122.5" "Cell type enriched" "Detected in some" 4 "Early spermatids: 428.1" "Cancer enhanced" "Detected in some" "head and neck cancer: 1.0" "Low region specificity" "Detected in single" "Immune cell enriched" "Detected in single" 10 "neutrophil: 1.0" "Lineage enriched" "Detected in single" 10 "granulocytes: 1.0" "Cell line enhanced" "Detected in some" "BEWO: 4.3;EFO-21: 5.0;Hep G2: 11.0;K-562: 4.3;LHCN-M2: 9.5;RH-30: 8.0" "Not detected" "Not detected" "Low region specificity" "Detected in all" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 34: Spermatids - Unknown function" "unprognostic (1.79e-1)" "unprognostic (2.39e-2)" "unprognostic (2.39e-1)" "unprognostic (7.07e-2)" "unprognostic (1.66e-3)" "unprognostic (2.47e-3)" "unprognostic (8.63e-2)" "unprognostic (1.97e-1)" "unprognostic (2.63e-2)" "unprognostic (1.27e-1)" "unprognostic (3.92e-1)" "unprognostic (2.22e-7)" "unprognostic (1.93e-2)" "unprognostic (1.54e-1)" "unprognostic (4.81e-1)" "unprognostic (2.09e-2)" 0.1 0.0 0.1 0.0 0.1 5.8 0.1 0.1 0.3 0.3 0.1 0.0 0.0 0.0 0.3 3.7 0.1 0.0 17.3 0.1 0.5 0.1 0.1 0.3 0.0 0.2 0.7 0.0 0.0 0.2 0.1 0.0 1.3 1.0 0.0 0.0 3.5 0.0 247.2 0.5 0.0 0.0 0.1 0.5 0.0 53.7 0.1 0.2 0.1 122.5 0.0 0.0 0.3 0.2 0.0 0.0 0.1 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.0 1.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 11.0 0.0 0.0 0.0 0.9 0.9 0.0 0.0 0.0 0.0 0.0 4.3 0.0 9.5 0.5 0.0 0.0 0.6 0.1 0.0 0.0 8.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.3 0.1 0.5 0.2 0.7 1.3 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.0 1.7 0.3 1.1 3.4 0.0 0.0 0.1 12.2 0.0 0.1 0.0 0.0 2.1 0.0 0.0 0.0 0.0 428.1 0.0 0.0 0.6 0.0 0.0 0.1 0.2 1.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 94.0 0.9 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.9 0.1 0.1 0.0 0.0 0.2 0.0 0.0 21.7 0.6 10.4 3.3 6.3 2.0 3.0 0.1 0.0 0.0 0.2 DUSP14 "MKP-L, MKP6" ENSG00000276023 "Dual specificity phosphatase 14" O95147 17 37489891-37513501 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skin 1: 44.1" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 179.7;Basal prostatic cells: 239.3;Cytotrophoblasts: 162.8;Endometrial ciliated cells: 146.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 1.6" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "HBF TERT88: 36.4;SuSa: 24.9;WM-115: 37.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019911 Approved Approved Nucleoplasm,Cytosol NA Yes 79000 "Cluster 33: Neutrophils - Chromatin organization" "Cluster 27: Brain & Skin - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Cytosol" "HPA019911: AB_1847888" "unprognostic (1.32e-1)" "unprognostic (3.06e-1)" "unprognostic (2.19e-2)" "unprognostic (1.57e-1)" "unprognostic (4.60e-1)" "unprognostic (3.22e-2)" "unprognostic (3.43e-3)" "unprognostic (2.02e-3)" "unprognostic (2.18e-1)" "unprognostic (2.59e-1)" "unprognostic (7.02e-3)" "unprognostic (3.81e-1)" "prognostic unfavorable (6.97e-9)" "unprognostic (7.93e-2)" "unprognostic (1.97e-1)" "unprognostic (1.73e-1)" "unprognostic (1.41e-3)" 15.3 14.2 10.9 1.3 11.2 0.3 12.4 11.2 17.0 12.8 10.9 10.3 0.0 9.5 5.5 17.4 7.5 1.2 14.1 11.0 10.9 8.7 15.2 8.6 0.4 11.9 11.1 5.6 6.6 1.0 14.5 0.9 10.6 6.4 1.0 9.9 13.1 0.3 11.0 44.1 5.5 0.8 10.4 2.8 7.6 13.7 10.8 4.4 23.1 4.4 2.7 7.2 17.1 10.7 2.6 0.2 4.9 2.1 0.1 0.6 2.1 10.4 7.8 14.3 15.6 1.2 17.9 0.2 0.9 7.6 0.2 2.8 0.2 6.1 36.4 0.2 0.7 0.0 1.6 6.2 1.5 0.5 3.0 8.5 5.5 4.8 2.5 10.2 0.3 0.2 0.6 3.1 11.4 0.4 9.7 1.7 0.3 3.8 0.0 2.5 0.6 2.5 17.5 2.4 1.9 0.3 0.5 17.6 4.1 24.9 0.8 3.9 1.4 10.8 5.8 0.1 5.8 0.1 0.3 0.1 0.1 0.0 37.5 1.1 0.0 0.7 0.1 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.7 1.6 0.0 0.2 0.0 0.0 0.2 10.9 11.2 11.2 17.0 11.0 10.9 11.9 11.1 10.6 10.4 10.8 10.7 15.0 6.4 5.4 2.9 8.3 179.7 239.3 74.8 129.1 6.8 42.6 46.0 15.0 4.3 39.6 7.3 8.4 162.8 16.6 0.3 29.4 34.8 36.4 146.9 18.5 21.7 2.4 11.4 12.0 15.1 82.1 30.2 3.1 85.3 87.0 10.6 14.6 15.7 19.7 15.2 5.3 1.2 36.7 2.8 34.8 52.5 13.7 5.9 62.2 4.7 25.3 16.1 15.5 3.0 3.3 74.8 2.9 6.0 9.9 64.9 0.1 16.9 61.3 24.5 0.0 13.2 45.2 26.0 33.4 44.0 92.6 67.9 18.2 26.3 1.1 67.0 DUSP15 "bA243J16.5, bA243J16.6, C20orf57, FLJ20645, VHY" ENSG00000149599 "Dual specificity phosphatase 15" Q9H1R2 20 31847637-31870747 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 4 "testis: 210.5" "Group enriched" "Detected in many" 4 "Distal tubular cells: 273.9;Early spermatids: 288.8;Late spermatids: 979.4" "Cancer enhanced" "Detected in many" "renal cancer: 6.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CACO-2: 4.8;REH: 16.0;SH-SY5Y: 4.3;SK-MEL-30: 4.0;U-2 OS: 3.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA076649 Enhanced Approved "Plasma membrane,Cytosol" NA NA "Cluster 43: Testis - Unknown function" "Cluster 14: REH - Unknown function" "Cluster 25: Spermatids - Spermatogenesis" "Plasma membrane, Cytosol" "HPA076649: AB_2686811" "unprognostic (3.84e-2)" "unprognostic (2.30e-1)" "unprognostic (2.28e-1)" "unprognostic (9.01e-3)" "unprognostic (3.88e-2)" "unprognostic (2.36e-1)" "unprognostic (1.47e-2)" "unprognostic (2.24e-2)" "unprognostic (1.43e-1)" "unprognostic (1.76e-1)" "unprognostic (1.48e-5)" "unprognostic (7.31e-2)" "prognostic favorable (5.40e-7)" "unprognostic (2.79e-2)" "unprognostic (1.93e-1)" "unprognostic (3.11e-3)" "unprognostic (2.55e-1)" 1.7 5.9 5.3 0.2 7.6 0.1 3.4 10.7 7.5 5.9 4.9 1.8 0.5 3.4 9.0 1.0 1.5 0.7 7.8 4.8 7.7 50.0 0.7 1.6 0.6 17.1 8.7 5.2 2.4 13.0 8.7 0.7 8.1 6.6 0.1 0.6 2.1 3.0 0.9 1.2 1.5 0.3 7.8 2.7 2.3 210.5 7.6 0.3 9.6 0.3 0.2 2.5 2.7 8.8 0.2 0.2 0.1 1.4 0.0 0.3 0.0 0.0 0.0 0.7 0.0 4.8 0.1 1.0 1.9 0.2 2.6 0.0 0.3 0.0 0.0 0.0 0.5 0.4 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.3 0.0 3.4 0.6 0.0 0.0 16.0 1.8 0.1 0.0 0.0 2.1 4.3 2.6 0.0 4.0 0.1 1.1 0.9 0.0 0.0 3.6 0.0 0.0 1.6 0.0 0.0 0.0 0.6 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.3 7.6 10.7 7.5 4.8 7.7 17.1 8.7 8.1 7.8 7.6 8.8 2.9 0.0 0.0 1.3 0.8 0.6 1.3 0.0 0.0 0.6 3.6 4.4 2.5 1.5 0.0 18.4 4.2 0.0 0.4 0.1 273.9 2.4 288.8 0.6 4.0 2.2 1.8 0.0 1.7 1.0 0.1 2.9 1.5 0.6 0.0 7.0 1.8 0.1 0.6 6.7 2.6 0.4 0.0 0.6 1.9 979.4 8.7 1.2 7.2 0.0 0.6 2.9 0.0 3.0 4.7 0.6 0.0 10.9 0.0 0.9 0.0 55.3 0.1 0.3 0.0 2.5 3.3 121.5 6.0 0.3 0.1 0.1 0.3 7.5 0.7 0.4 DUSP16 "KIAA1700, MKP-7, MKP7" ENSG00000111266 "Dual specificity phosphatase 16" Q9BY84 12 12473282-12562863 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Granulosa cells: 114.9;Oligodendrocytes: 196.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "T-reg: 3.9" "Lineage enriched" "Detected in single" 5 "T-cells: 3.9" "Cell line enhanced" "Detected in many" "NTERA-2: 37.7;RT4: 34.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA020326 Approved Supported Nucleoplasm NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 18: Non-specific - Mitochondria" "Cluster 5: NTERA-2 - Transcription" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "HPA020326: AB_1847890" "unprognostic (8.05e-2)" "unprognostic (9.47e-2)" "unprognostic (1.49e-3)" "unprognostic (4.14e-2)" "unprognostic (9.86e-2)" "prognostic favorable (1.01e-4)" "unprognostic (1.75e-2)" "unprognostic (3.52e-2)" "unprognostic (1.13e-2)" "unprognostic (2.11e-1)" "unprognostic (1.78e-1)" "unprognostic (2.82e-1)" "unprognostic (2.34e-3)" "unprognostic (6.35e-3)" "unprognostic (2.42e-1)" "unprognostic (1.46e-1)" "unprognostic (5.76e-2)" 9.3 47.8 4.9 7.8 8.3 3.6 15.0 7.7 5.3 12.2 6.3 11.3 13.6 11.3 6.2 12.7 10.5 8.0 7.2 4.8 6.0 7.6 33.3 12.0 6.4 7.3 8.1 10.7 18.8 8.0 12.9 5.5 6.2 19.7 10.9 7.5 14.6 3.4 11.3 11.1 13.1 4.9 5.4 6.8 13.2 7.1 6.7 15.2 8.8 4.7 9.0 10.7 17.0 11.8 4.5 6.5 7.6 4.2 2.8 3.3 13.6 2.6 5.8 6.4 9.1 18.1 8.6 0.4 1.4 2.9 11.3 2.9 14.1 2.4 8.6 14.4 7.0 0.7 6.8 19.2 5.4 1.3 3.0 2.8 6.7 5.1 16.3 6.8 5.0 7.3 4.0 11.8 0.4 8.6 1.7 0.9 37.7 11.1 1.9 2.0 2.6 8.6 3.6 34.3 12.3 11.5 10.6 13.6 6.7 28.2 5.5 2.2 4.5 2.9 8.3 1.8 2.9 8.3 10.6 1.5 3.8 2.9 4.0 0.0 0.0 0.0 0.5 0.0 2.3 0.0 1.6 0.7 0.1 0.0 0.5 0.3 0.8 0.0 0.0 0.0 3.9 0.3 4.9 8.3 7.7 5.3 4.8 6.0 7.3 8.1 6.2 5.4 6.7 11.8 9.6 28.9 55.5 30.3 3.3 2.8 14.9 1.5 3.4 4.8 23.8 13.1 11.5 20.0 9.7 3.7 2.1 10.5 5.6 35.7 0.0 14.3 1.3 15.1 10.2 9.2 49.6 0.0 19.5 24.6 4.1 9.9 11.7 19.9 23.5 114.9 7.5 34.2 5.3 6.7 24.8 10.0 2.0 9.4 1.9 2.3 5.9 5.7 5.4 38.4 2.9 36.8 0.0 56.3 196.3 20.9 25.3 6.8 4.3 34.3 25.4 5.2 10.4 4.8 0.0 11.1 10.3 3.0 5.8 6.2 1.8 30.1 27.9 9.9 18.7 24.5 DUSP18 DUSP20 ENSG00000167065 "Dual specificity phosphatase 18" Q8NEJ0 22 30652051-30667887 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 123.4;Late spermatids: 344.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034070, HPA051349" Uncertain Supported Nucleoplasm Yes No "Cluster 31: Non-specific - Inflammatory response" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "CAB034070: AB_2094867, HPA051349: AB_2681450" "unprognostic (1.11e-1)" "unprognostic (2.34e-2)" "unprognostic (3.49e-3)" "unprognostic (4.88e-3)" "unprognostic (1.88e-1)" "unprognostic (9.12e-2)" "unprognostic (3.77e-4)" "unprognostic (1.83e-1)" "unprognostic (1.61e-1)" "unprognostic (3.53e-2)" "unprognostic (9.62e-2)" "unprognostic (4.87e-2)" "unprognostic (1.23e-3)" "unprognostic (6.55e-2)" "unprognostic (1.97e-1)" "unprognostic (4.56e-2)" "unprognostic (1.02e-1)" 3.3 1.9 3.4 4.5 3.6 3.3 2.8 2.9 5.3 2.4 9.1 5.4 5.0 2.9 4.9 4.1 10.9 4.2 2.0 3.7 4.0 2.2 1.0 5.5 4.7 5.4 7.6 2.4 2.9 3.3 4.2 2.1 4.9 2.1 6.8 5.2 2.5 2.4 1.3 4.8 4.6 3.8 4.8 4.3 4.8 13.9 4.5 4.0 3.3 1.6 3.9 3.3 2.6 6.0 5.4 5.4 2.5 5.8 6.2 11.9 2.3 4.9 5.3 4.7 5.1 3.1 5.3 3.6 3.3 6.0 6.2 3.8 1.3 3.8 5.3 9.8 6.1 1.5 2.2 2.2 2.6 7.4 5.3 3.1 5.4 7.8 3.0 5.3 15.0 4.1 1.7 2.8 5.2 4.8 4.2 1.8 0.8 6.4 3.3 2.8 1.7 1.2 5.6 3.7 6.2 3.7 4.8 1.7 3.5 3.2 4.5 2.2 11.1 9.9 5.4 2.7 2.8 2.1 2.6 1.7 11.4 1.3 5.0 31.4 15.3 29.9 8.6 19.3 6.6 9.7 9.6 7.7 17.2 8.7 6.6 7.5 31.8 7.4 21.4 9.7 13.2 8.4 3.4 3.6 2.9 5.3 3.7 4.0 5.4 7.6 4.9 4.8 4.5 6.0 7.2 19.2 5.4 11.4 7.1 21.4 13.3 6.5 2.2 2.9 4.9 3.4 2.0 10.0 9.6 5.5 45.9 1.2 12.0 10.0 3.9 10.1 123.4 34.5 5.0 10.1 35.5 2.1 8.0 9.4 3.9 6.8 8.6 5.0 7.0 4.4 13.9 1.1 8.1 1.7 4.4 15.4 6.1 15.6 28.5 344.2 8.4 13.2 8.8 13.1 13.9 10.1 9.2 1.5 14.3 9.3 15.4 6.8 3.9 8.8 24.2 4.1 64.6 16.8 6.6 8.6 6.6 63.0 17.2 5.7 21.3 1.0 9.7 3.5 19.0 8.7 DUSP19 "DUSP17, SKRP1" ENSG00000162999 "Dual specificity phosphatase 19" Q8WTR2 2 183078559-183100008 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Early spermatids: 15.2;Endometrial ciliated cells: 17.7;Respiratory ciliated cells: 15.7;Spermatocytes: 15.5" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in many" 6 "amygdala: 1.3;basal ganglia: 2.4;cerebral cortex: 2.7;hippocampal formation: 3.8" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HEL: 7.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021501 Approved Approved Nucleoplasm Yes No "Cluster 35: T-regs - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 49: Ciliated cells - Cilium organization" Nucleoplasm "HPA021501: AB_1847892" "unprognostic (1.24e-1)" "unprognostic (2.13e-2)" "unprognostic (1.21e-1)" "unprognostic (1.64e-1)" "unprognostic (5.18e-2)" "unprognostic (2.44e-1)" "unprognostic (1.21e-1)" "unprognostic (1.88e-1)" "unprognostic (8.30e-2)" "unprognostic (1.49e-2)" "unprognostic (3.33e-2)" "unprognostic (6.53e-2)" "unprognostic (5.80e-3)" "unprognostic (6.97e-2)" "unprognostic (2.91e-2)" "unprognostic (2.16e-2)" "unprognostic (2.75e-2)" 1.1 1.4 1.3 0.8 2.4 0.3 1.1 0.0 2.7 1.2 0.1 1.4 1.4 1.4 3.5 1.4 3.2 1.3 3.1 3.8 0.1 1.8 1.1 1.3 1.0 0.1 0.0 1.6 0.9 1.6 1.2 1.0 0.0 1.5 1.0 1.2 0.9 1.9 1.6 1.3 1.1 1.9 0.0 1.6 3.9 3.7 0.0 1.2 1.7 1.7 0.7 1.1 0.6 0.4 0.1 1.6 1.8 0.9 2.5 1.4 0.0 0.7 1.1 2.9 1.0 1.5 1.9 0.6 3.8 0.8 2.1 0.2 3.8 0.5 2.3 3.9 1.8 7.1 1.1 1.0 1.0 1.8 4.2 1.1 0.3 1.3 0.7 1.8 1.5 0.0 2.2 1.0 1.8 0.6 3.4 1.6 1.5 0.6 1.2 3.3 2.9 0.2 0.6 0.7 2.3 0.9 2.6 1.1 2.0 0.1 0.5 0.6 1.3 1.6 1.3 1.1 0.6 1.3 1.6 0.0 2.0 0.3 2.4 0.7 0.1 0.6 0.6 0.2 0.6 1.1 0.5 0.8 0.1 0.5 0.7 0.7 0.3 0.7 0.1 0.4 1.0 0.3 1.3 2.4 0.0 2.7 3.8 0.1 0.1 0.0 0.0 0.0 0.0 0.4 2.5 0.0 3.2 0.7 1.6 1.0 1.3 1.1 3.4 1.8 2.1 2.7 8.3 1.5 1.8 1.8 2.1 2.0 0.8 1.5 5.9 0.9 15.2 17.7 2.3 3.3 2.4 0.0 9.9 0.7 1.5 1.7 3.6 1.5 1.3 3.0 2.9 1.9 0.6 1.7 7.8 1.9 0.0 0.8 0.3 6.0 1.8 2.2 0.0 1.0 1.1 4.8 2.1 4.0 3.1 0.6 3.4 2.6 0.3 0.7 2.2 2.9 15.7 1.5 0.0 1.9 4.4 15.5 3.8 2.3 1.6 0.7 1.2 3.6 1.8 1.1 DUSP2 PAC-1 ENSG00000158050 "Dual specificity phosphatase 2" Q05923 2 96143169-96145440 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 129.5" "Cell type enhanced" "Detected in many" "dendritic cells: 919.7;Glandular and luminal cells: 321.1;Langerhans cells: 924.0;Macrophages: 353.9;T-cells: 764.7" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in all" 4 "cerebral cortex: 55.0" "Immune cell enhanced" "Detected in all" "gdT-cell: 199.3" "Group enriched" "Detected in all" 10 "NK-cells: 148.1;T-cells: 199.3" "Cell line enhanced" "Detected in many" "Daudi: 30.4;HeLa: 29.7;JURKAT: 27.6;Karpas-707: 33.8;NB-4: 29.1;RT4: 34.2;SCLC-21H: 29.6;U-698: 43.2" "Low region specificity" "Detected in single" "Low region specificity" "Detected in some" HPA071920 Supported "Nucleoplasm,Nuclear membrane" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" "Nuclear membrane" Nucleoplasm "HPA071920: AB_2686472" "unprognostic (2.69e-3)" "unprognostic (6.70e-3)" "unprognostic (1.15e-1)" "unprognostic (5.46e-3)" "unprognostic (3.32e-2)" "unprognostic (8.54e-2)" "unprognostic (1.36e-1)" "unprognostic (1.15e-1)" "unprognostic (2.86e-1)" "unprognostic (3.66e-2)" "unprognostic (3.10e-1)" "unprognostic (6.30e-2)" "prognostic unfavorable (4.97e-5)" "unprognostic (1.82e-1)" "unprognostic (2.41e-1)" "unprognostic (3.94e-2)" "unprognostic (1.31e-3)" 17.0 6.0 7.6 18.6 11.6 129.5 5.5 7.5 55.0 8.1 9.2 4.5 1.6 7.0 7.7 6.8 7.6 12.5 19.5 13.4 6.2 12.7 7.5 18.2 47.1 8.0 6.3 7.8 2.3 1.7 35.1 1.3 6.7 17.6 2.0 0.4 3.9 61.5 2.8 26.0 11.8 3.4 6.7 42.0 7.4 3.6 6.9 47.3 6.7 3.7 24.6 39.5 9.0 9.3 3.2 0.0 0.2 0.2 0.4 0.5 4.4 3.7 0.0 5.3 5.1 8.9 0.6 30.4 10.6 4.1 0.0 2.2 7.5 0.0 1.0 0.5 0.0 0.7 29.7 0.0 1.9 12.8 2.6 0.9 2.0 0.9 0.0 0.1 0.0 27.6 0.0 33.8 0.2 5.2 25.5 29.1 6.5 0.8 10.6 0.0 0.4 24.3 0.2 34.2 29.6 1.5 1.4 0.3 5.6 0.0 2.0 14.4 0.1 0.0 7.9 0.0 1.7 2.3 3.9 43.2 0.0 13.9 0.3 2.3 4.3 1.0 199.3 10.5 95.4 17.5 46.7 176.2 10.7 13.9 32.0 99.3 6.1 148.1 9.1 3.0 16.1 40.5 7.6 11.6 7.5 55.0 13.4 6.2 8.0 6.3 6.7 6.7 6.9 9.3 50.8 0.0 7.7 0.7 303.7 96.7 155.0 31.3 70.6 27.8 65.8 72.0 37.8 2.8 12.0 9.2 22.9 0.9 919.7 20.4 1.9 0.9 0.9 115.6 62.7 28.7 87.8 50.5 5.2 1.4 1.7 22.8 86.6 321.1 104.3 7.4 12.8 3.9 80.2 0.0 1.4 37.5 8.2 40.4 924.0 1.4 1.8 353.9 144.1 1.9 3.4 1.5 90.6 1.0 0.5 1.0 2.5 1.9 268.5 70.4 1.6 1.4 2.7 3.6 0.0 14.7 26.6 0.6 4.8 50.4 109.7 1.6 764.7 3.0 51.6 41.1 DUSP21 ENSG00000189037 "Dual specificity phosphatase 21" Q9H596 X 44844021-44844888 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 41 "testis: 10.7" "Group enriched" "Detected in some" 99 "Early spermatids: 82.4;Late spermatids: 277.1" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 83: Testis - Spermatogenesis" "Cluster 31: Spermatids - Spermatogenesis" "unprognostic (5.17e-2)" 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 10.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 82.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 277.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 DUSP22 "JKAP, JSP1, MKPX, VHX" ENSG00000112679 "Dual specificity phosphatase 22" Q9NRW4 6 291630-351355 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RPMI-8226: 270.6;U-266/70: 130.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031394 Approved Approved Nucleoplasm,Vesicles NA NA "Cluster 37: B-cells - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 25: RPMI-8226 - Immune response" "Cluster 51: Myeloid cells - Hemostasis" "Nucleoplasm, Vesicles" "HPA031394: AB_10604114" "unprognostic (7.34e-3)" "unprognostic (7.94e-3)" "unprognostic (1.37e-2)" "unprognostic (1.14e-1)" "unprognostic (3.46e-1)" "unprognostic (1.70e-2)" "unprognostic (9.08e-3)" "unprognostic (2.48e-1)" "unprognostic (9.06e-2)" "unprognostic (5.56e-3)" "unprognostic (3.10e-2)" "unprognostic (3.04e-1)" "unprognostic (1.77e-1)" "unprognostic (3.97e-2)" "unprognostic (3.07e-1)" "unprognostic (2.35e-1)" "unprognostic (1.09e-1)" 36.9 16.4 25.6 27.7 29.1 23.7 33.0 27.4 28.8 31.6 21.2 47.8 22.5 28.9 12.2 45.7 25.9 21.3 42.1 25.1 27.1 32.4 32.7 38.5 32.4 32.3 28.5 19.6 40.8 13.2 21.2 27.3 30.3 23.2 16.1 7.8 30.4 15.1 52.3 41.4 33.7 22.0 28.0 43.9 32.7 44.9 29.3 15.0 28.1 37.7 30.5 30.3 36.8 42.7 13.7 8.3 17.3 25.9 19.5 21.5 22.8 9.9 8.0 8.6 10.3 8.8 15.1 28.4 23.3 10.3 18.3 9.4 21.9 18.3 6.1 68.6 25.1 19.3 7.1 24.7 9.9 7.0 24.4 16.2 54.1 6.2 11.3 14.1 24.8 24.0 18.3 92.2 7.2 8.2 10.3 25.1 10.4 10.0 18.7 20.2 11.7 270.6 16.2 5.8 29.7 11.6 8.5 3.4 29.6 37.4 17.6 8.9 34.2 7.7 10.1 7.8 6.0 130.0 98.6 40.0 3.0 19.0 17.7 36.4 32.5 13.6 8.6 26.5 6.2 40.4 6.7 9.1 33.5 33.3 6.1 8.8 21.8 5.9 25.1 28.8 15.9 19.6 25.6 29.1 27.4 28.8 25.1 27.1 32.3 28.5 30.3 28.0 29.3 42.7 45.5 16.0 21.3 5.5 53.7 26.5 22.0 33.3 14.2 5.7 19.4 17.5 40.8 10.0 30.7 5.5 0.0 10.8 51.1 11.7 21.5 24.2 13.4 18.6 8.2 33.4 9.5 8.2 8.5 51.4 7.7 21.9 15.3 12.9 33.0 8.8 21.8 25.0 30.1 0.0 6.1 14.7 32.6 38.6 43.0 20.5 15.5 47.1 46.2 21.5 78.4 14.9 36.0 7.1 25.9 29.2 12.4 9.4 59.7 16.5 23.2 18.2 39.7 3.2 26.3 11.6 22.8 34.5 73.8 42.5 37.1 6.6 21.3 6.8 15.4 27.9 DUSP23 "DUSP25, FLJ20442" ENSG00000158716 "Dual specificity phosphatase 23" Q9BVJ7 1 159780932-159782543 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Exocrine glandular cells: 458.5;Proximal tubular cells: 800.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HSkMC: 142.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028211, HPA045792" Approved Supported Nucleoplasm NA NA 22000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 43: THP-1 - Innate immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "HPA028211: AB_2672522, HPA045792: AB_10961133" "unprognostic (1.52e-1)" "unprognostic (4.12e-1)" "unprognostic (1.40e-3)" "unprognostic (3.33e-2)" "unprognostic (4.36e-2)" "unprognostic (3.22e-1)" "prognostic unfavorable (3.06e-4)" "unprognostic (3.16e-1)" "unprognostic (4.62e-1)" "unprognostic (3.33e-3)" "unprognostic (4.72e-2)" "unprognostic (3.75e-2)" "prognostic unfavorable (2.59e-5)" "unprognostic (8.58e-2)" "unprognostic (2.84e-2)" "unprognostic (7.47e-2)" "unprognostic (1.39e-1)" 75.0 122.4 29.1 15.4 31.5 20.5 99.9 32.0 38.5 57.6 30.0 46.3 26.7 55.0 15.5 82.0 52.3 13.4 36.1 31.8 31.4 199.1 189.3 55.3 10.4 32.0 30.1 35.6 76.8 34.6 20.8 5.9 32.1 55.3 13.9 8.1 152.4 15.3 65.4 61.1 42.9 12.0 32.8 39.2 39.7 18.2 31.3 15.2 58.8 16.6 9.1 45.1 53.6 31.0 39.5 42.2 0.3 0.2 39.5 33.5 0.4 15.8 13.0 18.4 14.3 17.3 44.7 0.1 90.9 17.6 4.2 1.5 10.8 14.5 10.0 9.9 4.6 54.4 14.7 0.0 58.6 33.3 40.4 142.8 38.3 12.1 43.0 13.2 71.0 0.1 25.2 19.4 26.3 72.5 3.5 1.4 71.3 71.6 58.7 0.1 0.0 18.8 22.7 6.9 17.8 39.4 28.6 63.0 78.5 7.3 40.6 51.7 51.7 15.3 0.8 1.9 0.2 13.5 34.8 0.5 25.8 26.5 11.7 111.8 181.7 229.1 97.9 153.4 54.6 60.5 72.7 92.8 261.3 43.7 44.0 65.1 185.6 100.5 105.6 59.2 70.8 112.2 29.1 31.5 32.0 38.5 31.8 31.4 32.0 30.1 32.1 32.8 31.3 31.0 100.4 41.7 58.7 3.3 23.8 74.6 129.2 151.8 100.7 8.5 110.6 112.1 29.5 95.8 122.2 51.5 6.2 16.1 28.4 97.7 262.2 210.7 48.3 47.5 30.8 155.8 35.4 37.5 1.4 458.5 29.2 31.2 32.1 130.9 54.5 66.1 75.0 249.4 170.3 1.7 0.5 124.9 91.6 94.3 72.9 8.4 26.4 92.2 42.7 4.7 58.9 74.8 69.0 1.0 4.4 208.4 112.2 15.8 14.6 121.5 140.4 800.7 54.8 10.0 13.1 16.0 34.9 5.4 19.9 123.2 74.4 5.7 43.6 72.3 109.5 116.1 DUSP26 "DUSP24, MGC1136, NEAP" ENSG00000133878 "Dual specificity phosphatase 26" Q9BV47 8 33591330-33600023 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "skeletal muscle: 421.3;tongue: 204.4" "Cell type enhanced" "Detected in some" "Bipolar cells: 76.8;Cardiomyocytes: 59.4;Cone photoreceptor cells: 41.7;Enteroendocrine cells: 25.7;Horizontal cells: 25.2;Rod photoreceptor cells: 75.2" "Cancer enhanced" "Detected in some" "glioma: 6.7;pancreatic cancer: 4.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "SCLC-21H: 97.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA018221 Approved Supported Nucleoplasm NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 80: Striated muscle - Unknown function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 56: Bipolar cells - Visual perception" Nucleoplasm "HPA018221: AB_2669813" "unprognostic (2.77e-4)" "unprognostic (2.70e-2)" "unprognostic (2.70e-3)" "unprognostic (5.47e-3)" "unprognostic (2.01e-1)" "unprognostic (1.24e-1)" "unprognostic (1.62e-1)" "unprognostic (2.53e-2)" "unprognostic (2.81e-1)" "unprognostic (1.39e-1)" "unprognostic (4.10e-3)" "unprognostic (1.78e-2)" "unprognostic (2.28e-1)" "unprognostic (1.52e-2)" "unprognostic (1.14e-1)" "unprognostic (8.15e-2)" "unprognostic (5.80e-2)" 0.7 27.4 44.2 1.2 45.2 0.2 0.4 47.4 49.6 1.2 18.4 2.8 3.5 1.3 5.6 5.0 3.6 1.2 70.8 45.0 53.0 1.5 0.2 3.3 0.4 39.8 42.1 33.2 3.0 2.0 61.4 0.0 55.2 4.2 1.1 34.1 4.6 0.8 421.3 0.3 2.6 2.7 38.3 0.7 3.9 3.6 44.4 0.8 0.9 204.4 0.8 1.2 1.7 41.1 0.0 0.0 0.4 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.3 0.1 0.1 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 1.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 97.7 23.1 0.0 0.1 0.0 0.0 1.1 0.0 0.0 0.0 0.2 0.1 0.1 3.1 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 44.2 45.2 47.4 49.6 45.0 53.0 39.8 42.1 55.2 38.3 44.4 41.1 0.0 0.0 0.0 1.3 0.9 0.0 0.2 0.0 0.6 76.8 0.0 0.3 59.4 0.0 0.0 0.0 41.7 0.0 0.0 0.0 21.5 0.4 7.8 0.4 0.1 0.8 25.7 0.0 11.3 0.4 0.0 3.5 0.5 0.1 0.0 1.0 0.4 0.0 0.0 25.2 14.7 0.5 0.0 0.0 0.0 5.2 0.0 0.1 1.8 2.8 0.0 22.8 0.0 12.1 12.0 1.1 0.0 6.0 5.3 0.3 0.0 2.5 0.0 75.2 0.0 10.8 5.2 0.2 0.2 0.0 0.0 0.0 0.6 0.7 0.1 0.1 DUSP28 "DUSP26, VHP" ENSG00000188542 "Dual specificity phosphatase 28" Q4G0W2 2 240560054-240565256 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Late spermatids: 39.7;Spermatocytes: 45.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "basophil: 8.9" "Lineage enriched" "Detected in all" 5 "granulocytes: 8.9" "Cell line enhanced" "Detected in many" "U-266/70: 8.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA047456, CAB069448" Uncertain Uncertain "Nuclear speckles,Cytosol" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 29: U-266 - Adaptive immune response" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "Nuclear speckles" Cytosol "CAB069448: , HPA047456: AB_10961145" "unprognostic (1.88e-2)" "unprognostic (9.29e-2)" "unprognostic (4.86e-2)" "unprognostic (2.32e-1)" "unprognostic (1.65e-1)" "unprognostic (1.07e-2)" "unprognostic (1.09e-2)" "unprognostic (7.56e-3)" "unprognostic (4.13e-3)" "unprognostic (3.71e-2)" "prognostic favorable (1.84e-4)" "unprognostic (9.85e-2)" "unprognostic (1.80e-3)" "unprognostic (6.99e-2)" "unprognostic (2.52e-1)" "unprognostic (2.59e-1)" "unprognostic (2.10e-3)" 1.5 2.4 1.6 1.3 1.7 5.4 1.7 3.0 1.8 2.2 0.5 2.5 1.1 2.1 1.7 3.1 2.6 0.8 3.4 1.3 1.7 3.2 3.2 2.2 1.9 1.7 1.2 2.2 3.0 0.9 3.9 0.6 1.4 3.5 1.0 1.2 2.8 0.8 9.8 2.0 3.6 0.6 1.1 4.7 2.7 6.2 1.5 1.1 3.5 4.0 1.5 2.3 2.2 2.0 1.0 0.8 1.1 1.4 0.7 0.4 1.3 1.0 0.6 0.8 0.5 0.5 2.4 1.7 0.6 0.6 1.3 3.1 0.9 0.3 0.7 2.2 4.0 2.1 2.2 1.3 0.5 1.6 3.7 1.0 0.9 0.6 0.6 1.6 0.4 2.3 1.6 1.9 0.7 1.1 1.7 2.5 0.9 1.4 0.9 2.3 2.4 2.1 0.6 1.6 2.8 1.5 0.9 1.1 1.3 0.7 1.2 2.2 1.0 1.9 1.6 1.3 1.0 8.2 2.1 2.8 1.2 1.0 1.5 8.9 1.1 0.5 1.2 0.7 1.4 1.0 1.2 1.3 0.6 1.8 1.4 1.2 1.9 1.5 0.7 1.9 0.9 0.9 1.6 1.7 3.0 1.8 1.3 1.7 1.7 1.2 1.4 1.1 1.5 2.0 5.7 0.0 4.5 1.3 11.4 3.7 7.7 4.7 6.2 6.7 12.3 10.0 13.8 10.0 3.8 12.9 4.2 7.8 18.4 11.0 15.6 5.1 35.2 11.2 5.5 4.1 8.4 8.8 3.8 5.8 4.8 4.3 14.8 10.2 7.0 6.2 3.3 8.6 11.5 8.4 4.9 9.8 6.1 10.0 6.1 39.7 3.1 13.6 7.2 1.9 10.5 9.9 23.7 2.5 3.6 4.4 10.4 1.5 16.8 8.0 15.7 15.6 11.7 6.8 6.6 4.1 7.2 45.8 18.7 10.7 5.4 7.0 14.9 7.6 11.2 8.7 DUSP29 "DUPD1, DUSP27" ENSG00000188716 "Dual specificity phosphatase 29" Q68J44 10 75037836-75058514 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "skeletal muscle: 71.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA042964 Uncertain NA NA "Cluster 33: Striated muscle - Muscle contraction" "HPA042964: AB_10795764" "unprognostic (1.05e-2)" "unprognostic (1.77e-1)" "unprognostic (2.34e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.5 0.0 0.0 0.9 0.0 71.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 DUSP3 VHR ENSG00000108861 "Dual specificity phosphatase 3" P51452 17 43766125-43778977 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 261.9" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 274.3;Late spermatids: 160.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 9 "dendritic cells: 33.5;granulocytes: 11.0;monocytes: 29.3" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063616 Supported Nucleoplasm,Cytosol NA NA 1300000 "Cluster 14: Monocytes - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm Cytosol "HPA063616: AB_2685061" "unprognostic (1.52e-1)" "unprognostic (3.18e-2)" "unprognostic (1.10e-1)" "unprognostic (8.54e-2)" "unprognostic (1.04e-3)" "prognostic unfavorable (3.00e-4)" "unprognostic (4.83e-2)" "unprognostic (8.98e-2)" "unprognostic (5.13e-1)" "unprognostic (6.01e-2)" "unprognostic (1.78e-1)" "unprognostic (8.40e-3)" "prognostic favorable (5.49e-5)" "unprognostic (2.67e-3)" "unprognostic (5.45e-2)" "unprognostic (1.94e-1)" "unprognostic (1.37e-2)" 39.8 43.2 63.6 21.6 67.1 9.9 32.7 57.2 91.0 32.4 59.6 96.1 27.8 49.2 31.1 48.4 33.6 33.4 194.8 69.0 65.4 72.0 108.1 50.2 14.3 64.2 64.3 18.2 48.6 47.0 33.1 31.4 64.4 57.7 26.0 30.8 31.8 72.9 261.9 24.6 38.7 62.9 58.5 40.7 57.5 24.5 65.6 6.2 30.5 213.7 13.0 63.1 33.6 64.3 32.3 57.1 21.5 23.1 61.1 32.7 18.3 23.8 56.4 54.4 65.1 55.4 21.1 4.9 36.7 44.7 112.4 27.3 33.7 29.3 56.9 11.1 25.6 16.2 25.9 45.4 74.5 2.0 16.1 30.5 51.5 42.0 36.2 59.0 38.5 15.9 14.7 5.4 64.2 23.1 8.5 8.4 9.9 45.5 41.1 10.5 64.5 12.1 75.8 33.3 12.0 21.6 27.9 18.3 71.8 58.8 82.2 44.7 40.4 61.1 41.5 87.9 40.1 28.5 40.4 1.2 72.4 22.6 20.8 11.0 29.3 6.4 1.5 15.0 2.7 2.6 2.4 1.9 33.5 2.4 1.9 1.7 7.0 1.7 20.6 13.8 1.6 11.4 63.6 67.1 57.2 91.0 69.0 65.4 64.2 64.3 64.4 58.5 65.6 64.3 23.1 25.6 21.2 6.5 9.2 22.4 47.6 17.6 10.8 17.2 20.3 21.3 274.3 54.3 17.9 42.3 25.0 16.3 9.5 36.9 41.1 47.8 88.6 18.8 16.6 33.8 36.4 11.6 18.1 58.9 21.8 25.9 42.8 25.0 38.7 6.1 25.4 108.8 86.6 20.2 15.5 19.9 24.4 49.1 52.0 160.5 14.6 47.2 10.6 15.9 53.9 16.8 4.1 8.5 13.8 56.5 32.3 26.4 8.0 46.2 57.7 87.6 21.1 17.3 32.9 24.1 28.4 3.3 5.0 16.0 28.8 45.0 6.3 15.1 18.0 42.6 DUSP4 "HVH2, MKP-2, TYP" ENSG00000120875 "Dual specificity phosphatase 4" Q13115 8 29333064-29350684 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pancreas: 32.2;stomach 1: 32.4" "Cell type enhanced" "Detected in many" "Glandular and luminal cells: 155.5;Ionocytes: 126.1;Pancreatic endocrine cells: 195.2" "Cancer enhanced" "Detected in all" "melanoma: 42.9" "Region enhanced" "Detected in many" "hippocampal formation: 20.9" "Immune cell enriched" "Detected in single" 9 "T-reg: 6.7" "Lineage enriched" "Detected in single" 20 "T-cells: 6.7" "Cell line enhanced" "Detected in many" "A549: 100.0;OE19: 91.7;SK-MEL-30: 157.2;WM-115: 122.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA061967 Supported Nucleoplasm NA NA "Cluster 35: T-regs - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 17: WM-115 - Nervous system development" "Cluster 41: Macrophages - Immune response" Nucleoplasm "HPA061967: AB_2684648" "unprognostic (1.92e-1)" "unprognostic (5.97e-3)" "unprognostic (3.24e-1)" "unprognostic (6.54e-2)" "unprognostic (2.18e-2)" "unprognostic (7.66e-3)" "unprognostic (7.30e-2)" "unprognostic (7.08e-2)" "unprognostic (1.83e-2)" "unprognostic (9.73e-3)" "unprognostic (9.60e-3)" "unprognostic (3.15e-2)" "prognostic unfavorable (4.19e-4)" "unprognostic (6.88e-2)" "unprognostic (1.62e-1)" "unprognostic (1.08e-2)" "unprognostic (6.07e-2)" 15.2 5.2 2.3 5.4 1.4 6.2 23.7 5.0 9.0 6.0 0.4 1.2 1.2 4.5 0.1 2.5 1.9 11.3 2.3 20.9 1.2 2.8 0.7 5.7 2.6 1.6 1.1 0.4 32.2 0.6 5.3 7.5 1.1 5.2 1.4 5.9 16.1 10.1 4.2 5.6 2.0 1.2 0.3 1.0 32.4 2.8 2.9 4.2 1.2 0.9 2.7 13.8 2.8 1.1 38.0 100.0 57.9 2.8 7.2 0.0 4.9 7.7 42.0 22.8 10.1 1.1 18.8 0.0 20.5 3.6 16.0 12.0 0.7 25.7 13.5 1.0 1.9 0.3 3.7 0.7 0.2 0.5 47.3 4.6 16.7 7.1 42.1 49.7 18.9 0.4 0.3 4.5 46.0 42.9 0.1 7.1 10.1 91.7 60.5 1.2 1.9 8.1 52.3 19.7 0.4 32.0 10.8 49.5 157.2 1.1 10.7 1.1 53.3 16.7 0.3 0.0 5.7 11.6 1.4 0.1 50.2 8.9 122.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 6.7 0.0 2.3 1.4 5.0 9.0 20.9 1.2 1.6 1.1 1.1 0.3 2.9 1.1 11.1 0.0 2.8 0.0 33.5 12.1 98.3 27.3 4.0 43.2 80.4 62.2 2.6 51.5 51.1 0.0 12.5 3.2 24.0 1.9 0.0 74.3 7.6 64.7 13.3 16.3 97.8 0.0 3.8 78.6 40.9 9.6 121.8 155.5 6.3 0.0 21.8 0.3 25.0 43.7 8.2 8.5 126.1 4.0 102.8 25.6 0.3 47.4 65.8 0.0 75.6 0.8 0.0 1.5 0.3 195.2 0.0 0.0 31.0 30.9 0.4 0.2 43.6 3.4 13.1 18.9 17.8 1.4 8.2 2.3 11.9 17.8 115.6 0.1 4.6 102.7 DUSP5 HVH3 ENSG00000138166 "Dual specificity phosphatase 5" Q16690 10 110497907-110511533 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "urinary bladder: 175.7" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 409.1;Langerhans cells: 298.4;Plasma cells: 412.2;Urothelial cells: 1063.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "non-classical monocyte: 10.3;plasmacytoid DC: 14.5" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "hTERT-HME1: 408.0;Karpas-707: 161.2;U-266/70: 227.8" "Region enhanced" "Detected in all" "cerebellum: 60.7" "Region enriched" "Detected in many" 5 "cerebellum: 45.4" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 22: Epithelial cell types - Mixed function" "unprognostic (1.25e-1)" "unprognostic (3.57e-1)" "unprognostic (5.19e-2)" "unprognostic (1.03e-1)" "unprognostic (1.76e-2)" "unprognostic (3.27e-3)" "unprognostic (6.35e-2)" "prognostic unfavorable (8.30e-6)" "unprognostic (1.70e-2)" "unprognostic (4.60e-2)" "unprognostic (2.91e-2)" "unprognostic (1.20e-2)" "unprognostic (4.20e-3)" "unprognostic (3.79e-1)" "unprognostic (3.78e-3)" "unprognostic (2.32e-1)" "unprognostic (9.09e-2)" 38.8 37.6 8.5 26.8 8.6 38.5 26.6 26.1 17.3 39.4 13.3 22.3 12.2 19.7 2.0 115.5 12.7 51.4 34.1 17.9 12.4 26.4 25.6 23.2 12.8 7.7 9.3 7.6 8.0 6.7 20.0 48.3 7.4 17.7 26.3 9.8 23.4 12.5 2.7 16.9 19.5 21.1 8.3 28.4 26.5 20.1 10.7 14.9 18.8 3.7 32.5 175.7 37.9 7.9 22.0 14.6 3.0 7.3 11.1 46.5 10.6 50.9 114.6 26.8 32.2 9.4 28.9 2.6 9.4 12.4 56.9 7.0 2.8 26.7 43.2 62.8 1.8 12.1 2.6 5.8 41.8 3.2 15.1 17.9 35.9 85.7 408.0 11.8 17.1 1.2 2.1 161.2 81.4 5.9 0.9 9.2 9.6 2.1 22.2 0.2 6.3 38.8 92.0 42.3 1.6 4.0 3.3 8.0 17.4 25.6 4.5 3.8 26.5 9.0 6.2 21.7 24.7 227.8 44.7 6.2 34.9 16.4 6.4 0.5 0.2 0.0 3.5 2.2 1.3 0.2 1.8 1.0 0.9 0.0 0.1 1.0 0.2 0.0 10.3 14.5 0.1 0.6 8.5 8.6 26.1 17.3 17.9 12.4 7.7 9.3 7.4 8.3 10.7 7.9 150.7 3.2 7.8 0.3 71.2 66.0 409.1 91.4 30.7 9.0 72.7 77.0 33.5 11.5 78.3 35.0 6.2 44.0 97.7 63.5 5.9 29.1 1.5 50.6 32.2 90.8 48.9 0.4 4.4 4.8 11.2 42.7 39.3 196.6 3.8 5.5 158.5 4.1 10.7 0.0 2.2 12.8 22.4 16.6 298.4 3.3 1.5 91.5 158.3 1.0 46.9 2.3 4.1 1.0 0.0 49.1 93.2 0.7 412.2 127.0 44.4 0.6 27.3 12.6 0.0 25.8 37.3 1.2 19.8 61.8 101.9 137.4 122.0 3.3 9.2 1063.2 DUSP6 "MKP-3, PYST1" ENSG00000139318 "Dual specificity phosphatase 6" Q16828 12 89347235-89352501 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Disease variant, Hypogonadotropic hypogonadism, Kallmann syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "salivary gland: 226.2" "Cell type enhanced" "Detected in all" "Alveolar cells type 2: 246.8;granulocytes: 456.9;Kupffer cells: 266.7" "Cancer enhanced" "Detected in all" "thyroid cancer: 97.6" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 1636.7" "Group enriched" "Detected in all" 13 "granulocytes: 1636.7;monocytes: 842.3" "Cell line enhanced" "Detected in many" "AN3-CA: 427.6;NB-4: 325.8;SK-MEL-30: 253.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017566, HPA053188, HPA064692" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 17: WM-115 - Nervous system development" "Cluster 60: Granulocytes - Receptor signaling" "Nucleoplasm, Cytosol" "CAB017566: AB_647991, HPA053188: , HPA064692: " "unprognostic (7.35e-2)" "unprognostic (1.50e-2)" "unprognostic (5.77e-2)" "prognostic favorable (7.21e-4)" "unprognostic (2.35e-3)" "unprognostic (2.10e-3)" "unprognostic (3.76e-2)" "unprognostic (1.42e-1)" "unprognostic (8.63e-2)" "unprognostic (1.67e-2)" "unprognostic (3.15e-3)" "unprognostic (2.09e-1)" "unprognostic (5.91e-3)" "unprognostic (1.28e-2)" "unprognostic (3.95e-2)" "unprognostic (1.86e-2)" "unprognostic (2.84e-1)" 113.9 24.7 12.0 63.7 12.9 178.7 50.8 10.0 28.5 39.4 29.8 47.3 24.8 26.2 14.2 34.8 36.6 75.5 30.9 19.8 11.6 58.9 143.3 88.2 42.3 12.6 12.1 14.2 17.9 34.6 17.8 74.1 12.4 18.8 56.1 6.8 226.2 22.9 8.5 17.4 52.1 43.2 12.7 71.0 28.7 6.9 16.0 47.7 77.4 40.2 27.2 76.4 13.8 13.6 6.4 6.2 127.0 427.6 108.1 89.9 0.2 47.5 58.3 9.5 6.8 38.7 6.8 0.0 11.2 20.5 17.9 51.4 0.5 118.4 13.0 0.5 0.8 20.0 1.4 61.4 75.7 86.3 210.9 18.4 40.4 81.5 75.5 94.9 214.4 2.6 0.0 20.4 29.3 3.1 2.9 325.8 78.7 149.5 102.7 216.6 15.5 8.3 129.3 129.7 2.4 88.7 1.1 0.6 253.0 43.3 6.4 46.8 59.0 30.6 0.8 5.8 22.8 3.7 18.5 0.5 126.5 60.0 200.3 1636.7 558.9 247.2 9.8 842.3 4.5 2.7 2.7 3.5 97.0 11.6 1.6 3.2 230.5 14.8 841.0 12.2 6.7 455.2 12.0 12.9 10.0 28.5 19.8 11.6 12.6 12.1 12.4 12.7 16.0 13.6 182.9 102.5 246.8 12.4 18.0 90.9 79.4 97.4 38.7 2.1 30.3 85.5 11.1 81.5 80.5 180.3 33.3 72.6 36.1 58.3 17.6 12.6 1.6 67.4 14.1 159.8 19.2 6.6 19.6 14.0 4.2 54.5 19.4 134.2 456.9 24.2 177.8 130.2 49.6 1.7 3.8 13.2 46.8 266.7 61.2 1.7 1.5 193.2 12.4 33.7 198.9 8.7 20.6 24.6 2.4 17.1 45.7 3.4 16.2 26.1 17.0 27.5 21.2 2.4 26.3 21.4 29.7 2.6 7.0 14.7 24.7 49.3 42.3 3.5 22.0 61.4 DUSP7 "MKP-X, PYST2" ENSG00000164086 "Dual specificity phosphatase 7" Q16829 3 52048919-52056571 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 117.3;Squamous epithelial cells: 51.6;Suprabasal keratinocytes: 135.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "hTCEpi: 109.8;hTERT-HME1: 92.6" "Low region specificity" "Detected in all" HPA073007 Approved NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 27: Brain & Skin - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 28: Keratinocytes - Keratinization" "HPA073007: " "unprognostic (1.19e-1)" "unprognostic (1.89e-1)" "unprognostic (1.66e-1)" "unprognostic (1.04e-1)" "unprognostic (1.88e-1)" "unprognostic (6.16e-3)" "unprognostic (2.32e-2)" "unprognostic (2.75e-1)" "unprognostic (1.44e-1)" "unprognostic (8.67e-3)" "unprognostic (7.38e-3)" "unprognostic (7.74e-3)" "prognostic unfavorable (8.84e-6)" "unprognostic (4.86e-2)" "unprognostic (1.24e-1)" "unprognostic (2.29e-2)" "unprognostic (9.46e-2)" 13.1 10.0 23.3 7.6 28.4 3.6 11.5 19.5 27.5 27.0 7.5 8.4 4.1 14.6 3.9 64.1 10.1 8.7 22.2 24.2 21.2 10.6 5.2 24.9 10.2 25.8 27.2 8.7 7.0 6.2 7.2 14.1 22.3 11.5 3.8 2.6 13.2 7.9 23.1 65.6 7.9 6.7 19.5 26.2 9.1 12.0 27.2 8.1 9.1 20.5 10.8 13.5 45.5 38.4 21.3 4.4 5.2 11.9 16.4 14.1 6.2 21.0 39.8 20.4 14.7 5.8 10.6 5.8 5.7 31.3 10.3 24.6 19.8 76.0 13.8 5.0 8.1 27.8 10.9 10.3 13.3 25.1 16.2 14.8 109.8 26.5 92.6 14.1 19.8 16.8 16.2 16.4 16.5 5.9 18.7 35.2 12.9 5.9 37.6 15.5 4.5 15.6 8.5 9.1 6.5 19.0 9.4 8.5 14.9 4.2 3.0 59.4 26.0 39.1 25.3 41.7 65.4 7.9 7.9 9.3 21.7 41.5 12.7 0.9 3.4 1.7 5.3 10.3 7.2 0.9 6.3 3.8 4.7 0.5 4.5 4.1 1.3 2.5 10.3 7.1 4.5 1.7 23.3 28.4 19.5 27.5 24.2 21.2 25.8 27.2 22.3 19.5 27.2 38.4 17.0 9.6 1.1 0.0 2.9 117.3 31.5 13.5 21.1 4.9 6.6 7.2 18.9 0.0 5.2 0.0 0.0 0.6 13.4 1.6 1.9 3.1 1.7 2.9 8.1 18.7 2.4 1.7 5.5 2.6 4.3 7.8 0.5 2.8 0.0 1.3 23.6 0.9 8.1 0.0 4.4 2.5 0.0 16.7 12.0 0.5 8.7 9.0 21.4 5.6 10.3 0.9 9.2 5.5 20.2 12.1 1.3 4.9 1.6 17.5 0.6 1.3 1.5 1.0 26.3 3.3 8.6 3.5 5.5 51.6 135.2 1.2 7.3 4.1 3.4 29.3 DUSP8 "C11orf81, FLJ42958, HB5, HVH-5" ENSG00000184545 "Dual specificity phosphatase 8" Q13202 11 1554051-1572271 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pituitary gland: 25.5" "Cell type enhanced" "Detected in many" "Bipolar cells: 113.6;Distal enterocytes: 57.8;Glandular and luminal cells: 65.6;Horizontal cells: 90.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "MCF7: 2.5;SCLC-21H: 1.4;SH-SY5Y: 1.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA020071 Approved Approved Cytosol NA NA "Cluster 72: Non-specific - Transcription" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 56: Bipolar cells - Visual perception" Cytosol "HPA020071: AB_1847903" "unprognostic (2.29e-1)" "unprognostic (4.15e-2)" "unprognostic (1.96e-1)" "unprognostic (4.00e-2)" "unprognostic (1.35e-1)" "unprognostic (7.58e-3)" "unprognostic (6.08e-2)" "unprognostic (1.11e-1)" "unprognostic (1.44e-3)" "unprognostic (1.81e-1)" "unprognostic (4.04e-3)" "unprognostic (1.82e-1)" "prognostic favorable (2.75e-6)" "unprognostic (1.51e-1)" "unprognostic (1.57e-1)" "unprognostic (8.65e-2)" "unprognostic (6.30e-2)" 6.6 2.1 3.5 0.2 3.0 1.0 6.0 0.3 8.1 5.1 0.0 11.3 0.0 8.4 0.6 1.4 8.7 0.5 17.0 5.0 0.1 5.4 3.6 9.5 0.3 1.9 0.4 2.4 15.7 0.2 25.5 0.1 0.1 5.1 0.3 1.6 6.1 0.2 13.3 4.3 6.8 1.2 0.3 3.1 8.3 3.1 0.7 0.2 3.7 0.0 0.1 3.6 4.2 2.0 0.6 0.3 0.4 0.0 0.0 0.0 1.1 0.1 0.4 0.1 0.6 0.6 0.0 0.0 0.2 0.1 0.0 0.9 0.0 0.1 0.3 1.1 0.6 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.7 0.0 2.5 0.0 0.1 0.1 0.0 0.7 0.0 0.0 0.3 0.0 0.0 1.4 1.7 0.1 0.2 0.3 0.0 0.1 0.0 0.0 0.1 0.8 0.3 0.8 0.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.5 3.0 0.3 8.1 5.0 0.1 1.9 0.4 0.1 0.3 0.7 2.0 14.9 3.2 1.1 0.0 6.3 9.8 8.1 2.7 2.8 113.6 32.1 24.3 6.0 14.3 3.2 12.9 47.9 0.3 11.1 57.8 1.9 7.7 0.3 31.5 24.7 6.5 42.3 0.0 11.1 11.3 0.5 4.3 8.6 65.6 0.0 0.4 1.4 0.6 0.5 90.9 11.3 32.6 6.1 0.0 3.4 0.2 0.6 4.7 5.4 2.8 1.0 22.3 1.0 3.0 5.2 11.0 22.4 0.4 4.7 17.4 19.1 1.6 2.8 35.5 6.6 8.0 15.1 0.8 0.6 2.2 4.8 5.9 10.5 0.7 25.0 14.2 DUSP9 "MKP-4, MKP4" ENSG00000130829 "Dual specificity phosphatase 9" Q99956 X 153642492-153651326 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 15 "kidney: 56.9;placenta: 72.6" "Group enriched" "Detected in some" 14 "Cytotrophoblasts: 1171.5;Distal tubular cells: 727.8;Syncytiotrophoblasts: 1735.1" "Cancer enhanced" "Detected in many" "liver cancer: 10.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in many" 9 "Hep G2: 372.7" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA003336 Enhanced Approved "Endoplasmic reticulum" NA NA "Cluster 28: Placenta - Pregnancy" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 47: Cytotrophoblasts - Unknown function" "Endoplasmic reticulum" "HPA003336: AB_1078709" "unprognostic (4.64e-2)" "unprognostic (6.48e-2)" "unprognostic (4.87e-2)" "prognostic unfavorable (1.60e-4)" "unprognostic (1.52e-2)" "unprognostic (2.74e-3)" "unprognostic (9.36e-3)" "unprognostic (6.15e-2)" "unprognostic (2.81e-1)" "unprognostic (3.03e-1)" "unprognostic (1.29e-2)" "unprognostic (1.38e-2)" "unprognostic (2.68e-7)" "unprognostic (4.49e-2)" "unprognostic (2.08e-1)" "unprognostic (2.77e-2)" "unprognostic (5.52e-2)" 0.2 0.0 4.1 0.0 3.3 0.0 0.2 1.7 3.8 0.1 1.1 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.0 4.0 1.9 56.9 1.1 0.0 0.0 2.1 2.5 0.8 0.5 0.7 0.0 72.6 2.2 0.1 0.0 0.0 0.5 0.3 0.0 0.1 0.1 0.0 1.9 0.0 0.0 1.6 2.8 0.0 0.0 0.0 0.0 0.7 0.1 2.6 1.6 0.8 0.1 32.6 0.0 0.0 10.3 0.1 0.0 0.0 0.0 6.5 2.0 0.0 15.8 0.0 1.2 7.5 39.9 1.0 0.0 1.1 7.3 0.0 3.0 372.7 0.0 0.0 5.6 0.0 0.5 0.0 0.0 0.0 0.0 0.2 9.7 0.0 0.0 2.1 0.1 0.8 1.1 1.8 14.8 0.0 0.0 0.0 0.1 9.4 0.4 1.2 2.3 2.8 1.6 0.9 0.6 3.9 0.2 0.0 7.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.1 3.3 1.7 3.8 4.0 1.9 2.1 2.5 2.2 1.9 2.8 2.6 0.0 0.0 0.0 3.6 0.5 0.6 1.0 0.6 2.8 0.0 0.2 3.4 2.3 1.5 0.0 11.0 0.0 1171.5 0.0 0.0 727.8 0.1 0.0 0.1 0.1 3.1 0.0 0.0 0.7 0.0 84.0 6.1 0.0 0.0 0.0 3.8 0.0 0.9 84.2 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.1 0.0 0.4 0.0 0.8 0.0 3.2 0.4 0.0 0.0 0.0 0.4 0.8 8.9 0.2 0.0 1735.1 0.2 10.8 0.1 1.1 DYRK1A "DYRK, DYRK1, MNBH" ENSG00000157540 "Dual specificity tyrosine phosphorylation regulated kinase 1A" Q13627 21 37365573-37526358 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Host-virus interaction" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 156.7;Inhibitory neurons: 158.4;Microglial cells: 176.1;Oligodendrocyte precursor cells: 158.3;Oligodendrocytes: 157.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015323, HPA015810" Approved Approved "Nucleoli fibrillar center,Cytosol" NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 36: HEL - Hemostasis" "Cluster 44: Endometrium - Transcription" Cytosol "Nucleoli fibrillar center" "HPA015323: AB_1847922, HPA015810: AB_1847921" "unprognostic (2.71e-1)" "unprognostic (3.35e-2)" "unprognostic (1.27e-1)" "unprognostic (5.62e-2)" "unprognostic (4.17e-2)" "unprognostic (1.41e-1)" "unprognostic (1.67e-1)" "unprognostic (9.28e-2)" "unprognostic (1.02e-1)" "unprognostic (1.51e-1)" "unprognostic (9.95e-2)" "unprognostic (7.39e-2)" "unprognostic (9.09e-2)" "unprognostic (1.07e-1)" "unprognostic (2.92e-2)" "unprognostic (3.14e-1)" "unprognostic (1.40e-2)" 23.1 20.4 17.8 22.5 19.9 71.4 22.3 29.9 20.7 23.9 22.2 22.2 18.7 26.6 22.0 18.8 22.6 19.9 28.9 21.3 19.2 19.9 19.8 22.3 30.1 12.1 14.7 29.6 21.5 27.8 20.2 23.0 13.3 18.8 21.6 27.8 21.3 19.2 49.4 24.2 21.7 24.1 12.8 30.4 22.8 29.9 18.6 45.8 25.7 45.2 26.7 24.3 21.1 20.9 23.5 18.2 36.3 25.6 17.1 18.8 32.7 20.8 26.0 20.3 22.0 25.7 19.7 31.7 13.8 37.0 27.1 15.8 27.3 21.2 24.4 49.7 11.6 93.6 30.9 16.1 26.5 36.9 32.3 18.7 24.3 26.5 41.2 23.5 22.3 44.2 36.4 70.4 22.2 23.6 49.3 25.9 38.5 24.1 10.8 62.8 19.7 29.6 22.3 30.4 36.5 20.4 47.1 31.6 33.2 12.2 29.9 34.8 27.8 27.6 8.3 17.2 17.4 47.7 41.6 44.9 22.0 41.8 30.7 3.1 0.5 0.8 1.2 0.8 0.7 1.1 1.3 1.0 0.7 1.0 1.4 1.3 2.3 0.5 1.1 1.3 1.3 0.3 17.8 19.9 29.9 20.7 21.3 19.2 12.1 14.7 13.3 12.8 18.6 20.9 36.8 19.2 25.5 114.3 28.8 37.5 24.1 15.7 18.2 32.7 28.3 18.0 73.0 20.0 23.0 11.0 27.1 10.3 43.0 30.1 0.0 13.5 29.7 44.2 39.3 31.9 21.4 26.1 156.7 14.6 12.4 25.2 21.4 71.4 24.7 35.9 27.1 18.1 15.8 47.1 158.4 18.8 14.2 25.0 27.7 22.2 16.1 32.4 24.9 176.1 18.8 16.4 21.6 158.3 157.2 21.2 22.4 19.5 33.8 29.8 17.1 9.9 27.9 21.8 13.1 38.4 32.5 15.3 24.7 24.6 31.7 15.3 36.8 21.3 19.3 37.2 DYRK1B MIRK ENSG00000105204 "Dual specificity tyrosine phosphorylation regulated kinase 1B" Q9Y463 19 39825350-39834201 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Diabetes mellitus, Obesity" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 131.3;testis: 83.8" "Group enriched" "Detected in many" 12 "Early spermatids: 179.4;Late spermatids: 580.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "SH-SY5Y: 14.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028522, HPA028786" Uncertain Supported "Nucleoplasm,Mitotic chromosome" Yes No "Cluster 15: NK-cells - Transcription" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "Mitotic chromosome" "HPA028522: AB_2672656, HPA028786: AB_10670831" "unprognostic (2.22e-2)" "unprognostic (9.86e-2)" "unprognostic (4.55e-2)" "unprognostic (3.45e-3)" "unprognostic (1.96e-1)" "unprognostic (1.13e-2)" "unprognostic (2.25e-1)" "unprognostic (2.39e-1)" "unprognostic (6.02e-2)" "unprognostic (3.67e-2)" "unprognostic (8.93e-2)" "unprognostic (4.22e-2)" "prognostic favorable (8.83e-4)" "unprognostic (9.73e-2)" "unprognostic (1.12e-1)" "unprognostic (2.53e-2)" "unprognostic (3.88e-2)" 9.5 19.6 4.8 2.7 4.8 4.7 10.9 4.1 6.2 12.5 4.8 12.4 5.3 11.9 7.8 11.7 13.8 3.3 20.0 4.7 3.6 16.2 7.5 8.8 4.6 3.5 3.4 11.6 10.3 6.5 31.5 2.7 3.6 13.0 2.1 4.1 14.3 3.3 131.3 14.8 10.2 2.6 1.2 14.0 12.1 83.8 3.6 5.2 16.5 49.9 2.5 11.4 10.5 3.0 0.4 9.3 8.8 6.2 4.9 4.6 0.7 2.9 1.8 2.6 2.3 0.9 3.6 1.4 11.0 3.4 0.1 3.2 1.3 2.0 2.3 5.4 7.8 0.6 5.9 0.9 4.1 0.3 1.9 6.2 1.2 0.8 2.9 8.6 0.6 3.5 1.5 2.0 0.4 4.7 2.1 0.8 2.2 2.7 2.1 1.0 0.2 0.6 5.7 2.2 12.7 14.5 4.5 4.4 0.2 4.6 4.4 0.5 4.5 1.1 2.0 1.0 0.9 3.2 1.1 1.0 7.4 0.9 0.4 0.7 1.6 1.8 3.0 1.7 3.6 2.4 2.0 3.1 1.9 1.6 1.0 1.7 2.5 3.3 1.6 4.5 2.2 1.7 4.8 4.8 4.1 6.2 4.7 3.6 3.5 3.4 3.6 1.2 3.6 3.0 6.0 0.0 0.6 6.2 10.9 3.4 3.8 8.4 10.2 15.2 9.0 6.1 6.1 7.2 3.4 16.5 20.9 2.1 21.7 10.3 9.8 13.1 179.4 15.4 6.7 7.3 20.4 19.8 4.6 4.3 1.7 5.1 7.7 10.1 1.3 11.9 12.1 3.9 5.9 10.1 6.3 9.8 10.2 8.2 3.0 580.2 7.2 4.7 5.4 7.5 5.7 8.3 10.3 5.0 3.2 9.7 9.7 5.3 5.0 4.8 11.5 17.4 10.7 13.0 0.0 11.1 4.8 30.1 13.4 6.1 2.8 1.4 10.8 20.2 7.4 3.6 DYRK2 ENSG00000127334 "Dual specificity tyrosine phosphorylation regulated kinase 2" Q92630 12 67648338-67665406 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Ubl conjugation pathway" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 133.1;Horizontal cells: 80.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027230, HPA056902" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 15: NK-cells - Transcription" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm Cytosol "HPA027230: AB_1847925, HPA056902: AB_2683271" "unprognostic (5.86e-3)" "unprognostic (4.18e-1)" "unprognostic (4.08e-3)" "unprognostic (2.56e-3)" "unprognostic (1.18e-2)" "unprognostic (1.69e-1)" "unprognostic (3.37e-3)" "unprognostic (7.83e-2)" "unprognostic (2.83e-2)" "unprognostic (1.22e-1)" "unprognostic (1.04e-1)" "unprognostic (3.47e-1)" "unprognostic (2.12e-2)" "unprognostic (2.03e-2)" "unprognostic (1.38e-1)" "unprognostic (1.57e-1)" "unprognostic (1.35e-1)" 9.9 4.6 2.9 14.2 3.3 14.9 6.3 2.3 6.1 7.8 3.2 25.7 20.4 13.1 6.2 10.7 10.0 14.3 24.4 8.6 2.3 4.7 4.2 9.1 21.6 3.4 2.3 8.7 8.6 4.9 3.0 14.1 2.7 6.5 21.9 14.8 5.4 8.8 39.4 7.5 28.0 13.0 3.1 14.7 20.6 5.0 2.7 24.1 6.9 10.4 14.2 11.9 7.6 3.5 24.5 13.4 19.8 14.4 9.7 13.2 15.8 24.2 15.7 11.6 6.6 17.9 13.2 45.3 29.2 35.3 7.1 27.8 16.0 9.6 12.4 19.6 20.9 7.3 9.5 6.9 3.8 16.8 15.2 11.0 13.3 31.4 24.8 19.6 6.6 18.9 9.2 22.9 15.1 13.9 14.4 8.2 17.2 15.8 21.5 37.9 19.7 20.0 13.6 30.2 26.0 30.7 10.1 13.4 13.9 13.3 9.2 13.9 10.0 18.4 17.3 12.8 19.4 10.9 1.9 24.9 17.6 11.1 19.4 2.0 0.3 4.0 3.2 0.7 2.3 1.8 2.3 4.2 1.2 2.0 1.9 3.7 0.4 4.7 0.9 0.5 2.0 1.1 2.9 3.3 2.3 6.1 8.6 2.3 3.4 2.3 2.7 3.1 2.7 3.5 13.0 9.6 10.2 3.9 14.4 11.3 11.9 6.7 8.6 18.0 7.4 8.1 44.5 20.0 11.2 1.8 22.9 3.5 28.6 133.1 0.0 19.0 0.6 28.0 35.9 12.1 24.6 4.8 11.0 18.2 7.9 18.9 25.0 15.6 5.7 13.3 6.4 6.1 17.0 80.8 11.4 62.0 4.1 15.7 22.5 2.0 11.5 15.5 8.8 13.1 12.0 16.7 42.2 6.0 9.1 17.7 61.3 13.2 9.0 16.1 62.9 11.3 30.3 23.3 13.1 53.5 33.6 2.7 10.1 15.6 16.2 4.5 31.0 17.9 32.3 34.4 DYRK3 "hYAK3-2, RED, REDK" ENSG00000143479 "Dual specificity tyrosine phosphorylation regulated kinase 3" O43781 1 206635536-206684419 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 48.0" "Cell type enhanced" "Detected in many" "Early spermatids: 235.3;Late spermatids: 48.1;Spermatocytes: 108.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "plasmacytoid DC: 2.7" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "hTERT-HME1: 73.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA075041 Supported Nucleoplasm,Cytosol NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 30: Epithelial cell lines - Translation" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm Cytosol "HPA075041: AB_2686730" "unprognostic (6.51e-2)" "unprognostic (1.24e-2)" "unprognostic (3.36e-2)" "unprognostic (2.03e-1)" "unprognostic (2.81e-2)" "unprognostic (1.23e-1)" "unprognostic (1.20e-4)" "unprognostic (2.69e-1)" "unprognostic (3.91e-1)" "unprognostic (2.71e-1)" "unprognostic (2.79e-3)" "unprognostic (2.52e-1)" "prognostic unfavorable (9.41e-7)" "unprognostic (2.38e-1)" "unprognostic (2.04e-1)" "unprognostic (1.99e-2)" "unprognostic (7.62e-3)" 7.6 2.4 3.7 4.2 3.8 8.8 5.7 1.7 3.7 5.6 5.6 2.3 1.0 5.3 3.1 2.8 5.7 13.5 8.3 5.1 3.8 3.3 4.1 5.5 1.6 3.8 5.1 4.9 3.9 3.0 6.5 1.2 3.4 2.9 1.4 6.4 4.3 3.0 0.8 1.5 1.7 8.1 2.6 1.3 3.1 48.0 3.8 5.9 8.3 1.9 1.8 7.5 2.8 3.5 5.0 6.7 1.6 9.8 16.7 15.9 0.4 15.4 36.7 15.0 19.6 0.4 2.7 7.6 2.2 20.1 25.8 1.5 8.6 14.1 15.8 0.1 4.8 10.5 8.9 1.7 26.9 7.5 6.8 10.9 8.9 25.6 73.6 15.1 11.8 11.6 20.1 1.4 23.2 2.0 16.9 4.4 13.2 0.5 10.8 41.1 4.9 0.1 4.8 0.4 9.3 6.9 13.6 0.6 20.3 2.0 2.0 1.9 8.1 31.1 11.2 14.8 13.2 5.6 2.2 9.1 17.7 8.3 2.9 0.7 0.0 0.2 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.1 0.1 0.1 0.5 0.0 0.0 2.7 0.0 0.0 3.7 3.8 1.7 3.7 5.1 3.8 3.8 5.1 3.4 2.6 3.8 3.5 13.9 3.2 8.2 4.2 1.0 6.5 10.7 9.6 3.4 0.2 4.7 3.3 10.8 1.5 4.2 1.8 10.4 0.0 1.5 0.3 0.0 5.1 235.3 12.6 8.0 8.5 2.4 23.6 3.6 2.2 0.1 12.7 1.1 5.9 0.0 3.4 3.9 1.1 1.0 0.0 1.5 0.4 2.0 1.0 4.6 48.1 4.1 2.9 8.8 1.0 1.0 3.4 0.0 2.5 0.3 1.2 1.2 1.9 2.1 3.8 0.2 1.7 10.5 8.2 6.6 10.2 10.4 108.7 6.4 1.3 3.7 0.4 2.4 3.0 0.6 5.3 DYRK4 ENSG00000010219 "Dual specificity tyrosine phosphorylation regulated kinase 4" Q9NR20 12 4562204-4615302 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 36.7" "Group enriched" "Detected in all" 5 "Early spermatids: 392.2;Late spermatids: 393.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA028065, HPA056073" Enhanced Enhanced Vesicles No No "Cluster 14: Monocytes - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 34: Spermatids - Unknown function" Vesicles "HPA028065: AB_10601212, HPA056073: AB_2683028" "unprognostic (2.50e-1)" "unprognostic (1.55e-1)" "unprognostic (1.22e-1)" "unprognostic (3.56e-3)" "unprognostic (2.62e-1)" "unprognostic (4.07e-3)" "unprognostic (2.03e-2)" "unprognostic (4.69e-2)" "unprognostic (1.29e-1)" "unprognostic (7.13e-2)" "unprognostic (1.22e-2)" "unprognostic (2.46e-1)" "prognostic unfavorable (6.52e-6)" "unprognostic (1.86e-1)" "unprognostic (9.71e-2)" "unprognostic (1.04e-1)" "unprognostic (3.98e-2)" 2.1 4.2 3.9 3.4 4.2 4.6 6.4 5.1 7.6 5.9 4.2 5.4 4.6 5.0 17.0 4.0 5.0 4.4 4.7 4.2 4.4 3.5 4.2 4.7 5.9 4.4 4.5 5.1 3.0 5.0 3.6 6.8 4.8 5.0 6.2 7.7 3.7 7.2 2.2 4.9 4.0 5.1 4.1 6.2 3.2 36.7 4.8 4.3 9.1 4.1 5.4 4.7 2.0 5.7 2.0 3.2 3.9 4.3 5.8 7.1 4.7 2.4 4.8 5.4 5.9 0.6 3.2 6.1 0.3 6.9 3.7 4.2 3.0 4.5 4.2 4.7 6.8 4.2 1.0 3.6 16.4 3.7 3.3 4.9 9.6 3.8 12.4 10.1 7.8 6.5 1.8 6.7 4.9 4.3 3.5 9.1 5.3 1.0 1.8 0.7 2.8 2.6 6.7 1.9 0.0 1.5 0.5 2.4 3.3 8.4 1.9 3.3 0.5 6.3 4.9 0.6 3.1 1.9 2.6 3.8 3.3 5.8 3.3 0.3 1.7 0.8 0.5 1.3 0.6 4.4 0.8 0.9 1.6 3.0 0.8 0.9 0.0 0.7 3.5 0.8 0.7 0.8 3.9 4.2 5.1 7.6 4.2 4.4 4.4 4.5 4.8 4.1 4.8 5.7 13.0 12.8 16.2 11.1 15.8 8.9 13.2 31.2 14.8 20.7 21.2 30.4 23.8 7.2 19.9 16.5 10.4 15.7 16.7 5.2 31.3 25.1 392.2 14.0 22.5 15.5 5.4 12.2 10.3 27.1 12.0 17.3 14.3 13.3 17.7 19.0 8.2 9.8 49.7 13.5 10.4 75.4 14.2 16.1 9.3 393.1 15.2 18.7 16.0 9.4 14.5 19.4 13.4 14.1 16.1 20.1 14.2 31.6 22.9 16.4 7.3 35.6 13.9 21.7 6.6 15.2 17.6 23.7 39.0 20.4 7.5 9.9 12.7 40.6 17.3 11.8 EGFR "ERBB, ERBB1" ENSG00000146648 "Epidermal growth factor receptor" P00533 7 55019017-55211628 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" "Host-virus interaction" "Developmental protein, Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 287.9;Skeletal myocytes: 251.2;Syncytiotrophoblasts: 376.8" "Cancer enhanced" "Detected in all" "glioma: 136.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in many" 13 "A-431: 5282.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000035, HPA001200, HPA018530, CAB068186, CAB073534" Enhanced Enhanced "Plasma membrane,Cell Junctions" "Secreted to blood" NA NA 4740000 88000000 "Cluster 31: Skin - Epidermis development" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane, Cell Junctions" "CAB000035: , CAB068186: AB_2665679, CAB073534: , HPA001200: AB_1078723, HPA018530: AB_1848044" "unprognostic (2.62e-2)" "unprognostic (9.56e-3)" "unprognostic (1.59e-1)" "unprognostic (7.51e-2)" "unprognostic (1.08e-1)" "unprognostic (1.27e-2)" "unprognostic (6.11e-2)" "unprognostic (4.88e-2)" "unprognostic (2.85e-2)" "unprognostic (3.30e-3)" "unprognostic (1.78e-3)" "unprognostic (1.04e-1)" "unprognostic (1.93e-3)" "unprognostic (6.98e-3)" "unprognostic (1.72e-1)" "unprognostic (6.62e-2)" "prognostic unfavorable (2.04e-5)" 27.9 11.4 12.6 4.0 18.3 0.0 20.0 16.6 9.7 20.4 10.5 12.2 5.7 11.4 10.3 23.5 13.9 9.0 7.1 6.3 10.3 11.6 35.3 14.9 2.5 10.4 19.0 15.1 15.8 3.5 2.9 67.9 8.9 16.2 10.7 10.2 22.1 15.0 10.9 51.0 9.5 9.3 7.5 5.1 11.1 4.2 22.6 12.8 20.6 20.6 8.3 14.7 24.1 6.3 5282.1 61.9 16.5 22.4 102.7 63.5 16.7 47.9 68.7 30.8 23.8 11.5 54.2 2.7 11.4 43.8 130.7 197.1 0.4 230.2 37.1 2.2 3.6 0.1 27.3 3.4 27.0 0.0 0.2 31.2 205.4 74.1 409.9 45.5 4.0 0.0 0.0 0.5 68.0 3.0 0.1 0.1 5.1 21.2 30.4 0.1 9.1 0.2 38.1 52.6 0.8 20.0 42.7 50.6 9.3 16.8 4.9 12.0 15.6 27.1 7.2 215.7 45.8 0.1 4.8 3.1 37.9 1.6 8.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.6 18.3 16.6 9.7 6.3 10.3 10.4 19.0 8.9 7.5 22.6 6.3 16.4 96.1 49.9 147.6 1.2 85.8 77.1 101.5 116.1 3.5 12.1 30.4 11.1 47.1 50.6 22.0 6.2 287.9 0.0 45.9 0.0 32.9 4.9 25.9 57.2 12.5 4.2 8.0 1.2 24.3 37.1 91.6 22.4 39.8 0.0 50.6 6.8 79.5 28.3 0.0 107.5 21.6 48.8 7.7 11.6 5.8 128.3 1.9 17.8 40.3 1.6 90.0 0.0 63.3 1.4 54.8 19.9 133.5 0.0 75.4 14.1 13.4 21.7 3.8 78.9 251.2 34.7 2.4 2.5 73.3 89.9 376.8 2.2 41.9 24.9 55.8 EPHA1 "EPH, EPHT, EPHT1" ENSG00000146904 "EPH receptor A1" P21709 7 143390289-143408856 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Angiogenesis, Cell adhesion" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "esophagus: 57.2;parathyroid gland: 206.5" "Cell type enhanced" "Detected in many" "Early spermatids: 23.3;Gastric mucus-secreting cells: 13.3;Proximal enterocytes: 13.2;Squamous epithelial cells: 28.7" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "memory CD4 T-cell: 1.9;naive CD4 T-cell: 3.8;naive CD8 T-cell: 2.9" "Lineage enriched" "Detected in single" 8 "T-cells: 3.8" "Cell line enhanced" "Detected in some" "CACO-2: 17.9;HaCaT: 16.6;HBEC3-KT: 13.5;MCF7: 15.0;NTERA-2: 54.4" "Low region specificity" "Detected in single" "Low region specificity" "Detected in single" CAB026144 Uncertain NA NA 32000000 "Cluster 32: T-cells - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 5: NTERA-2 - Transcription" "Cluster 61: Squamous epithelial cells - Keratinization" "CAB026144: " "unprognostic (1.54e-2)" "unprognostic (3.04e-2)" "unprognostic (2.07e-1)" "unprognostic (4.58e-3)" "unprognostic (5.82e-3)" "unprognostic (2.45e-2)" "unprognostic (9.56e-2)" "unprognostic (1.81e-2)" "unprognostic (5.09e-1)" "unprognostic (7.59e-3)" "unprognostic (6.54e-2)" "unprognostic (3.24e-3)" "prognostic favorable (1.14e-6)" "unprognostic (3.73e-2)" "unprognostic (3.28e-2)" "unprognostic (1.91e-1)" "unprognostic (1.21e-1)" 0.1 0.0 0.0 1.3 0.0 0.3 2.2 0.4 0.1 11.2 1.2 3.7 8.4 0.3 1.2 57.2 3.4 1.5 0.0 0.0 0.0 5.8 15.6 2.3 2.0 0.0 0.0 0.0 5.7 206.5 2.5 0.6 0.0 4.0 1.6 0.0 11.0 1.2 0.0 19.7 6.2 0.1 0.0 0.9 4.2 1.9 0.0 3.4 5.4 0.0 3.5 1.9 25.8 0.1 8.7 0.0 0.0 0.0 0.0 0.0 7.9 0.0 0.0 0.0 0.0 17.9 7.1 0.0 0.1 0.0 0.0 16.6 0.0 13.5 0.0 0.0 0.0 1.8 0.0 1.7 0.0 0.8 0.1 0.0 4.4 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 15.0 0.0 1.9 54.4 8.8 0.0 0.0 0.0 0.0 1.1 6.7 0.3 0.0 0.0 8.2 0.0 3.2 3.8 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 3.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.5 0.2 0.0 3.8 2.9 0.1 0.1 0.0 0.4 0.1 1.0 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 2.2 0.3 0.1 2.0 6.3 6.5 6.8 0.0 3.3 5.0 1.0 2.8 9.9 7.3 0.0 2.0 0.2 4.2 0.0 4.4 23.3 4.0 1.0 0.2 1.2 0.0 0.6 4.3 2.6 0.5 13.3 6.6 0.0 0.0 0.4 8.8 0.4 0.0 0.3 4.7 2.0 0.3 0.3 9.9 0.6 0.3 0.0 1.0 0.0 0.3 0.0 0.5 0.2 6.3 8.8 0.0 0.6 2.0 13.2 1.5 2.1 0.2 0.0 0.4 0.4 0.5 1.9 28.7 3.7 1.0 4.4 0.0 7.6 5.5 EPHA10 "FLJ16103, FLJ33655" ENSG00000183317 "EPH receptor A10" Q5JZY3 1 37713880-37765133 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 7.6;intestine: 13.4;testis: 13.4" "Group enriched" "Detected in some" 4 "Cone photoreceptor cells: 91.8;Early spermatids: 59.1;Late spermatids: 183.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 4.9;HDLM-2: 19.4;SCLC-21H: 8.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA027497 Uncertain "Intracellular and membrane" NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 44: HDLM-2 - Immune response" "Cluster 25: Spermatids - Spermatogenesis" "HPA027497: AB_10601158" "unprognostic (9.27e-2)" "unprognostic (1.21e-1)" "unprognostic (2.94e-2)" "unprognostic (1.24e-6)" "unprognostic (1.06e-1)" "unprognostic (1.11e-2)" "unprognostic (5.39e-2)" "unprognostic (1.25e-1)" "unprognostic (2.55e-2)" "unprognostic (1.40e-1)" "unprognostic (7.06e-3)" "unprognostic (1.50e-1)" "unprognostic (8.81e-5)" "unprognostic (2.55e-2)" "unprognostic (2.97e-2)" "unprognostic (2.67e-1)" "unprognostic (3.04e-2)" 0.0 0.4 4.2 0.9 4.4 0.3 0.9 0.0 7.6 0.2 0.0 13.4 3.5 0.1 3.9 0.4 0.9 1.0 0.1 4.3 2.1 0.2 0.0 0.1 0.2 1.9 0.4 0.0 2.6 1.3 6.7 0.0 0.7 0.6 6.3 3.1 1.4 0.2 0.0 0.2 6.7 0.4 0.0 0.1 3.1 13.4 4.1 0.1 0.4 0.0 0.1 0.2 0.2 1.8 1.5 1.0 0.0 0.0 0.0 0.0 4.9 0.0 0.0 0.0 0.0 1.6 2.7 0.0 0.4 0.0 0.2 0.1 0.1 0.0 0.0 19.4 0.7 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.7 0.0 1.0 0.0 0.1 0.7 2.0 0.6 0.0 0.0 0.4 0.3 1.7 8.6 0.4 1.1 0.0 0.0 0.2 2.8 0.1 0.0 0.0 0.9 0.1 0.0 1.7 1.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 4.2 4.4 0.0 7.6 4.3 2.1 1.9 0.4 0.7 0.0 4.1 1.8 0.0 0.0 0.5 0.3 0.2 0.1 0.0 0.0 0.0 5.6 1.3 0.9 1.5 0.0 0.1 0.0 91.8 0.0 0.0 23.8 0.0 0.4 59.1 0.0 0.0 0.1 18.7 0.0 24.5 2.5 0.0 0.3 1.5 0.1 0.0 0.1 0.0 0.0 0.0 11.8 15.8 10.5 0.0 0.0 0.0 183.7 1.8 0.1 0.0 1.0 0.0 0.4 0.0 2.5 2.2 2.3 21.1 0.4 0.0 0.2 7.8 0.0 0.0 3.1 0.0 0.0 0.1 18.2 2.6 0.0 0.0 0.0 0.1 0.0 11.0 0.2 EPHA2 ECK ENSG00000142627 "EPH receptor A2" P29317 1 16124337-16156069 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, RAS pathway related proteins" "Angiogenesis, Apoptosis, Cell adhesion, Differentiation, Host-virus interaction" "Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Cataract, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 147.9" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 202.3;Glandular and luminal cells: 182.9;Squamous epithelial cells: 156.3;Suprabasal keratinocytes: 248.3;Urothelial cells: 200.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 94 "plasmacytoid DC: 9.4" "Lineage enriched" "Detected in single" 94 "dendritic cells: 9.4" "Cell line enhanced" "Detected in many" "CAPAN-2: 201.1;PC-3: 229.0;U-251 MG: 242.1;WM-115: 258.2" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" CAB010464 Supported "Nuclear speckles,Golgi apparatus,Plasma membrane,Cell Junctions" NA Yes 12000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 44: Endometrium - Transcription" "Plasma membrane, Cell Junctions" "Nuclear speckles, Golgi apparatus" "CAB010464: AB_631436" "unprognostic (9.41e-2)" "unprognostic (1.67e-1)" "unprognostic (4.13e-2)" "unprognostic (1.67e-2)" "unprognostic (6.22e-2)" "unprognostic (9.12e-2)" "unprognostic (5.24e-2)" "unprognostic (1.29e-3)" "unprognostic (2.52e-2)" "unprognostic (7.05e-3)" "unprognostic (1.52e-3)" "unprognostic (2.77e-1)" "unprognostic (2.65e-2)" "unprognostic (2.08e-1)" "unprognostic (1.73e-1)" "unprognostic (4.77e-3)" "unprognostic (4.40e-2)" 21.4 9.5 3.5 4.8 3.1 0.3 14.6 2.9 3.7 38.2 11.7 12.4 10.0 12.1 1.3 147.9 13.5 28.2 15.8 3.1 3.1 18.7 18.9 17.9 7.6 3.8 3.7 5.8 23.2 3.7 7.4 14.0 3.8 11.2 5.8 6.4 67.7 4.2 4.6 40.3 12.8 3.7 3.6 7.6 15.6 1.8 4.3 3.2 15.2 5.1 11.1 56.1 58.8 3.1 76.9 151.7 41.4 20.1 2.9 3.5 24.3 45.2 63.4 79.9 50.6 63.9 201.1 0.1 189.8 25.9 98.8 30.6 9.9 104.4 27.6 0.4 7.0 0.0 46.7 41.1 51.3 0.1 0.2 4.8 38.1 43.7 95.6 125.0 86.4 0.0 0.3 0.1 51.6 24.3 0.0 0.0 20.0 57.2 229.0 0.1 37.6 0.2 85.1 39.0 0.1 6.4 87.8 21.2 6.1 21.3 3.0 0.9 108.1 28.5 76.7 2.0 242.1 0.0 0.5 0.6 22.0 0.1 258.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.4 0.0 0.0 3.5 3.1 2.9 3.7 3.1 3.1 3.8 3.7 3.8 3.6 4.3 3.1 17.1 54.5 38.4 2.0 1.2 202.3 114.3 110.9 66.0 2.7 39.5 43.9 6.5 44.3 113.4 9.2 4.2 9.7 8.9 96.8 0.0 33.8 5.8 104.5 19.2 26.3 3.0 0.0 0.1 14.2 1.2 5.8 68.3 182.9 5.7 0.4 29.3 23.3 1.9 0.0 0.2 42.0 34.6 1.6 17.0 0.2 3.4 3.7 26.6 4.7 1.1 7.1 0.0 0.0 0.0 104.6 111.7 0.0 0.0 60.8 22.4 1.8 89.8 2.5 32.9 11.6 21.2 0.2 0.8 156.3 248.3 7.5 2.6 0.4 42.9 200.4 EPHA3 "ETK, ETK1, HEK, HEK4, TYRO4" ENSG00000044524 "EPH receptor A3" P29320 3 89107621-89482134 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "prostate: 31.5" "Group enriched" "Detected in some" 4 "Excitatory neurons: 70.6;Inhibitory neurons: 106.6;Microglial cells: 103.0;Oligodendrocytes: 48.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "AF22: 197.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB010462, HPA069390" Approved Supported "Nucleoplasm,Nuclear membrane,Plasma membrane,Actin filaments,Cytosol" "Intracellular and membrane" NA NA "Cluster 46: Fibroblasts - ECM organization" "Cluster 12: NES - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nuclear membrane, Plasma membrane, Cytosol" "Nucleoplasm, Actin filaments" "CAB010462: AB_2099218, HPA069390: " "unprognostic (1.48e-3)" "unprognostic (2.30e-2)" "unprognostic (4.95e-2)" "unprognostic (1.90e-1)" "unprognostic (2.96e-2)" "unprognostic (1.47e-2)" "unprognostic (2.03e-1)" "unprognostic (9.10e-3)" "unprognostic (1.24e-3)" "unprognostic (7.43e-2)" "unprognostic (1.83e-1)" "unprognostic (2.23e-1)" "prognostic unfavorable (3.28e-7)" "unprognostic (3.63e-2)" "unprognostic (1.88e-2)" "unprognostic (4.05e-2)" "unprognostic (1.20e-2)" 5.4 1.0 2.1 1.8 1.3 0.0 2.3 0.2 3.8 12.3 0.1 3.8 2.3 5.5 0.2 3.2 1.3 18.8 8.2 2.2 0.7 1.3 4.9 2.4 3.6 3.3 0.9 4.1 2.1 1.0 0.9 20.1 4.0 31.5 6.2 8.0 2.2 7.1 0.8 0.7 2.4 7.9 0.8 0.9 2.5 1.0 1.7 1.0 11.0 6.3 3.2 14.3 6.4 2.2 0.0 0.0 197.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.6 0.0 0.0 0.0 11.2 0.2 0.7 0.0 2.4 0.0 0.0 11.8 0.0 0.0 1.7 2.0 0.0 3.9 0.0 0.0 0.6 0.0 2.5 0.1 0.3 0.0 2.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.1 0.0 0.1 0.0 0.5 0.1 0.1 36.1 0.1 0.0 0.0 1.7 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 1.3 0.2 3.8 2.2 0.7 3.3 0.9 4.0 0.8 1.7 2.2 2.2 0.0 0.0 5.5 0.0 0.5 0.3 0.0 0.6 6.4 0.0 0.1 2.4 0.0 0.0 0.0 2.1 0.2 0.0 0.0 0.0 0.0 1.8 0.0 0.5 1.8 0.0 0.0 70.6 0.0 0.1 18.1 0.5 0.0 0.0 0.0 1.1 0.0 0.1 20.2 106.6 0.0 0.0 0.0 0.7 1.6 2.1 0.1 0.0 103.0 0.0 4.7 0.0 2.5 48.0 0.0 0.0 8.2 0.0 0.1 0.0 0.0 0.0 18.7 6.6 0.7 19.2 0.1 0.0 0.3 0.3 0.5 0.2 1.3 0.0 0.1 EPHA4 "Hek8, TYRO1" ENSG00000116106 "EPH receptor A4" P54764 2 221418027-221574202 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 39.7" "Cell type enriched" "Detected in many" 4 "Excitatory neurons: 317.9" "Cancer enhanced" "Detected in many" "thyroid cancer: 14.9" "Group enriched" "Detected in many" 6 "cerebral cortex: 23.8;hippocampal formation: 20.9" "Group enriched" "Detected in many" 9 "basophil: 1.6;gdT-cell: 1.7;MAIT T-cell: 1.7;memory B-cell: 1.3;memory CD4 T-cell: 2.5;memory CD8 T-cell: 1.7;naive B-cell: 1.2;naive CD4 T-cell: 1.0;NK-cell: 3.5;T-reg: 1.2" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "AF22: 77.0;ASC diff: 33.9;CACO-2: 59.3;U-2197: 38.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB028368 Enhanced NA NA 9300000 "Cluster 22: NK-cells - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "CAB028368: AB_2099353" "unprognostic (1.28e-1)" "unprognostic (5.87e-2)" "unprognostic (2.28e-1)" "unprognostic (2.46e-2)" "unprognostic (5.99e-2)" "unprognostic (1.33e-1)" "unprognostic (7.05e-4)" "unprognostic (1.80e-2)" "unprognostic (2.40e-1)" "prognostic unfavorable (9.56e-4)" "unprognostic (1.12e-1)" "unprognostic (2.85e-2)" "prognostic favorable (5.67e-4)" "unprognostic (3.12e-2)" "unprognostic (1.96e-1)" "unprognostic (2.36e-1)" "unprognostic (8.66e-2)" 7.8 1.6 0.0 1.9 3.9 3.7 3.9 0.0 23.8 4.5 39.7 4.6 1.0 6.4 2.8 4.8 4.9 3.1 17.4 20.9 0.0 4.8 0.8 3.6 2.7 0.0 1.5 11.1 1.1 1.9 0.6 1.6 0.0 5.3 4.5 4.2 2.6 6.1 2.7 12.9 2.8 8.0 0.0 3.4 2.3 11.7 3.7 3.8 9.5 4.0 3.2 3.6 3.5 0.0 2.6 2.4 77.0 0.0 33.9 20.9 0.1 18.2 8.3 16.9 6.2 59.3 0.9 0.0 0.1 26.7 0.0 7.0 12.3 0.1 7.0 9.7 6.4 0.0 0.9 0.0 0.9 0.0 1.4 8.5 4.2 5.3 0.1 10.3 14.9 0.0 0.0 0.0 4.4 9.5 0.2 0.0 5.6 5.9 1.7 0.1 8.5 0.0 25.8 4.3 13.2 0.0 6.2 1.3 1.3 6.2 2.9 0.0 0.0 1.7 3.2 38.4 1.0 0.0 0.1 0.0 6.9 0.0 3.6 1.6 0.0 0.0 1.7 0.0 1.7 1.3 2.5 1.7 0.0 1.2 1.0 0.2 0.1 3.5 0.0 0.1 1.2 0.4 0.0 3.9 0.0 23.8 20.9 0.0 0.0 1.5 0.0 0.0 3.7 0.0 36.3 0.0 6.4 51.9 8.2 6.1 0.7 9.7 2.8 9.8 4.3 6.0 31.6 7.2 13.7 9.2 0.0 0.1 12.2 4.7 7.9 0.2 3.9 1.9 5.7 26.3 3.5 0.0 317.9 0.2 0.0 5.1 4.6 5.2 1.3 9.0 20.0 0.4 0.3 1.7 68.8 12.8 8.2 0.0 1.5 5.8 1.2 0.9 7.2 70.3 0.2 7.2 3.1 8.0 7.9 30.9 3.6 8.6 2.1 1.4 0.1 1.7 4.5 3.2 0.0 3.6 10.2 10.0 1.9 4.1 12.5 0.0 5.4 11.3 6.6 2.4 EPHA5 "CEK7, EHK1, Hek7, TYRO4" ENSG00000145242 "EPH receptor A5" P54756 4 65319563-65670495 "Enzymes, Metabolic proteins, Predicted membrane proteins" Neurogenesis "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 9 "brain: 21.3" "Group enriched" "Detected in some" 10 "Excitatory neurons: 202.5;Inhibitory neurons: 162.8;Oligodendrocyte precursor cells: 96.0" "Cancer enhanced" "Detected in some" "glioma: 0.8;prostate cancer: 0.5" "Region enhanced" "Detected in many" "cerebral cortex: 21.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "hTERT-RPE1: 10.0;PC-3: 9.4;TIME: 12.6;U-138 MG: 25.5;U-2197: 15.7;U-251 MG: 20.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA 33000 "Cluster 10: Brain - Neuronal signaling" "Cluster 18: U-2197 - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (1.02e-2)" "unprognostic (4.22e-2)" "unprognostic (2.38e-1)" "unprognostic (4.89e-4)" "unprognostic (7.43e-4)" "unprognostic (1.60e-1)" "unprognostic (6.68e-3)" "unprognostic (2.49e-1)" "unprognostic (1.12e-1)" "unprognostic (1.03e-2)" "unprognostic (9.25e-2)" "unprognostic (5.88e-3)" "unprognostic (2.55e-2)" "unprognostic (5.97e-4)" "unprognostic (3.81e-3)" 0.0 0.8 3.3 0.1 5.3 0.0 0.0 0.0 21.3 2.0 0.0 0.1 0.0 0.4 0.0 0.1 0.0 0.0 0.8 16.2 2.4 0.0 0.0 0.1 0.0 2.6 1.4 2.3 0.0 0.0 0.7 0.9 4.0 1.5 0.1 1.5 0.3 1.4 0.0 0.2 0.0 0.2 1.8 0.3 0.3 0.7 0.3 0.0 0.9 0.0 0.0 0.1 0.5 3.1 0.0 0.7 0.8 0.0 0.8 0.4 0.0 0.4 1.3 0.7 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.3 0.0 4.4 0.0 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 10.0 0.3 0.0 0.0 1.5 2.6 0.0 0.0 0.0 0.1 0.0 9.4 0.0 2.9 0.5 0.0 0.0 1.1 0.0 0.0 0.0 4.3 0.0 0.0 0.0 12.6 25.5 3.1 15.7 20.6 0.0 0.0 0.0 2.6 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 5.3 0.0 21.3 16.2 2.4 2.6 1.4 4.0 1.8 0.3 3.1 0.0 0.0 0.0 8.5 0.0 0.5 0.0 0.0 0.0 2.7 0.0 0.1 4.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.4 0.0 2.2 0.1 0.0 0.0 202.5 0.0 0.0 0.7 0.0 0.0 0.0 0.8 0.0 0.0 0.1 1.7 162.8 0.0 0.0 0.0 0.0 15.2 0.9 0.0 3.6 5.6 0.0 5.7 0.0 96.0 4.8 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.4 0.0 0.0 0.4 0.7 0.4 0.0 0.1 0.0 0.0 0.7 0.0 0.1 EPHA6 FLJ35246 ENSG00000080224 "EPH receptor A6" Q9UF33 3 96814581-97752460 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "brain: 24.2;ovary: 6.3;testis: 8.4" "Cell type enhanced" "Detected in some" "Astrocytes: 421.5;Early spermatids: 401.8;Excitatory neurons: 423.8;Inhibitory neurons: 879.2;Late spermatids: 208.7" "Cancer enhanced" "Detected in single" "prostate cancer: 0.7" "Region enhanced" "Detected in many" "cerebellum: 24.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "HEK 293: 9.3;U-266/70: 28.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007397, HPA058047" Uncertain Enhanced Nucleoplasm NA NA "Cluster 6: Brain - Smell perception" "Cluster 29: U-266 - Adaptive immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA007397: AB_2667821, HPA058047: AB_2683588" "unprognostic (9.87e-2)" "unprognostic (1.67e-2)" "unprognostic (3.42e-4)" "unprognostic (7.21e-5)" "unprognostic (8.51e-2)" "unprognostic (1.32e-1)" "unprognostic (1.82e-2)" "unprognostic (3.14e-1)" "unprognostic (1.87e-1)" "unprognostic (1.34e-1)" "unprognostic (2.22e-1)" "unprognostic (1.71e-4)" "unprognostic (1.93e-3)" "unprognostic (1.76e-1)" "unprognostic (1.48e-2)" "unprognostic (7.14e-3)" 0.2 0.0 6.5 0.0 12.7 0.0 0.2 24.2 10.9 0.8 0.0 3.2 0.1 0.9 0.3 0.8 1.9 0.9 0.3 11.4 0.0 0.4 0.0 0.1 0.0 0.0 0.2 6.3 0.5 0.1 0.1 0.0 1.1 1.0 0.7 1.1 0.1 0.6 0.0 0.0 0.3 1.4 0.1 0.0 0.6 8.4 3.5 0.2 2.0 0.1 0.1 1.4 0.6 0.0 0.0 0.3 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 9.3 0.0 2.2 0.0 0.0 2.3 0.0 0.0 0.4 0.0 0.9 0.9 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.8 1.0 0.0 0.0 0.0 0.0 0.5 0.0 0.1 0.0 2.4 0.0 0.9 28.1 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.5 12.7 24.2 10.9 11.4 0.0 0.0 0.2 1.1 0.1 3.5 0.0 0.0 0.0 0.0 421.5 0.1 0.3 0.3 0.0 5.2 1.6 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 401.8 0.1 1.4 0.1 0.0 0.0 423.8 0.0 0.0 0.9 0.0 0.1 0.0 0.3 0.0 0.0 0.1 0.0 879.2 0.0 0.0 0.0 0.0 208.7 3.1 0.2 0.0 30.0 0.0 1.0 0.0 31.2 9.0 0.1 0.0 1.5 0.0 0.1 0.0 1.7 0.0 0.3 0.0 0.2 0.1 14.7 2.7 6.0 0.0 0.1 0.0 0.4 0.0 0.1 EPHA7 Hek11 ENSG00000135333 "EPH receptor A7" Q15375 6 93240020-93419687 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "intestine: 24.6;parathyroid gland: 69.9" "Group enriched" "Detected in some" 8 "Excitatory neurons: 138.6;Inhibitory neurons: 172.0" "Cancer enhanced" "Detected in many" "renal cancer: 6.4" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "AF22: 12.0;HEK 293: 35.1;RH-30: 31.7;THP-1: 32.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB010496 Approved "Intracellular and membrane" NA NA 660000 "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 43: THP-1 - Innate immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB010496: AB_2099673" "unprognostic (3.34e-1)" "unprognostic (7.82e-2)" "unprognostic (1.41e-1)" "unprognostic (9.32e-2)" "unprognostic (1.19e-1)" "unprognostic (3.56e-2)" "unprognostic (1.62e-2)" "unprognostic (4.07e-1)" "unprognostic (4.16e-2)" "unprognostic (3.19e-2)" "unprognostic (5.69e-2)" "unprognostic (1.69e-1)" "unprognostic (1.74e-2)" "unprognostic (1.35e-1)" "unprognostic (1.56e-2)" "unprognostic (4.82e-2)" 0.3 0.0 1.2 0.4 3.4 0.0 1.2 3.4 5.1 1.4 0.0 24.6 1.5 0.9 0.2 0.2 0.5 2.2 3.6 4.9 2.6 5.9 0.0 0.2 0.0 1.2 2.2 1.9 0.1 69.9 1.2 0.4 1.5 9.7 2.5 1.8 5.4 0.9 0.1 0.2 4.4 2.1 0.4 3.9 10.3 0.9 0.6 0.0 0.1 0.1 0.0 8.2 1.8 1.2 0.0 0.5 12.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 35.1 0.0 3.0 0.0 0.0 0.0 0.0 0.5 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0 5.8 0.0 0.0 0.0 0.6 0.0 1.0 5.4 31.7 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.1 0.0 32.6 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 3.4 3.4 5.1 4.9 2.6 1.2 2.2 1.5 0.4 0.6 1.2 0.2 0.0 0.0 4.2 0.0 0.4 0.4 0.0 0.6 18.5 3.1 1.8 17.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 13.1 1.3 1.4 1.8 0.0 0.0 138.6 0.0 0.0 5.9 0.0 3.8 0.0 3.7 0.0 0.0 0.1 11.8 172.0 0.0 0.0 0.0 0.4 3.3 0.9 0.1 0.0 11.2 0.0 0.4 0.0 4.5 8.3 0.1 0.0 0.0 0.0 0.4 0.0 11.8 0.0 1.0 0.0 0.2 0.5 0.2 1.1 0.2 1.0 0.0 0.2 0.9 0.0 0.1 EPHA8 "EEK, Hek3" ENSG00000070886 "EPH receptor A8" P29322 1 22563489-22603595 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "choroid plexus: 27.8" "Cell type enhanced" "Detected in some" "Bipolar cells: 4.2;Cone photoreceptor cells: 2.1;Early spermatids: 2.8;Horizontal cells: 3.3;Late spermatids: 5.8;Rod photoreceptor cells: 8.8" "Cancer enhanced" "Detected in single" "testis cancer: 0.5" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 12 "SCLC-21H: 59.6" "Region enhanced" "Detected in many" "cerebellum: 13.0" "Region enriched" "Detected in many" 4 "cerebellum: 11.7" "CAB009660, HPA031433" Uncertain "Intracellular and membrane" NA NA "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 46: Photoreceptor cells - Phototransduction" "CAB009660: AB_2099696, HPA031433: AB_10601371" "unprognostic (8.58e-2)" "unprognostic (8.59e-2)" "unprognostic (3.72e-1)" "unprognostic (1.15e-2)" "unprognostic (4.69e-4)" "unprognostic (3.58e-1)" "unprognostic (7.14e-2)" "unprognostic (1.52e-1)" "unprognostic (4.75e-2)" "unprognostic (9.80e-2)" "unprognostic (2.10e-1)" "unprognostic (9.84e-14)" "unprognostic (2.14e-3)" "unprognostic (1.69e-1)" "unprognostic (2.76e-1)" "unprognostic (8.68e-2)" 0.0 3.5 2.7 0.0 2.3 0.0 0.0 1.5 2.3 0.0 27.8 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 4.9 5.3 0.0 0.0 0.0 0.0 1.9 3.1 0.0 3.3 0.0 1.5 0.0 2.0 0.0 0.0 2.2 0.0 0.0 0.0 0.1 0.0 0.0 2.3 4.6 0.0 2.2 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 59.6 4.8 0.0 0.1 0.0 0.0 1.5 0.0 0.0 0.0 0.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 2.3 1.5 2.3 4.9 5.3 1.9 3.1 2.0 2.3 4.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.2 0.1 0.0 1.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.1 0.0 0.0 0.6 0.2 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 3.3 1.3 0.0 0.0 0.0 0.0 5.8 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.1 0.1 0.0 0.4 0.0 0.1 0.0 0.0 0.0 8.8 0.0 0.0 0.1 1.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 EPHB1 "EPHT2, Hek6" ENSG00000154928 "EPH receptor B1" P54762 3 134597801-135260467 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion, Neurogenesis" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 40.6" "Cell type enhanced" "Detected in many" "Astrocytes: 198.8;dendritic cells: 53.7;Early spermatids: 42.2;Excitatory neurons: 47.9;Inhibitory neurons: 44.3;Late spermatids: 41.2;Oligodendrocyte precursor cells: 77.9" "Cancer enriched" "Detected in many" 6 "glioma: 7.0" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 33 "neutrophil: 24.0;plasmacytoid DC: 23.3" "Group enriched" "Detected in many" 33 "dendritic cells: 23.3;granulocytes: 24.0" "Group enriched" "Detected in some" 5 "HDLM-2: 63.9;HMC-1: 35.5;RPTEC TERT1: 16.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA067740 Enhanced Approved "Endoplasmic reticulum,Plasma membrane,Cytosol" NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 44: HDLM-2 - Immune response" "Cluster 64: Astrocytes - Nervous system maintenance" "Endoplasmic reticulum, Plasma membrane, Cytosol" "HPA067740: AB_2685895" "unprognostic (1.99e-1)" "unprognostic (3.45e-1)" "unprognostic (2.52e-1)" "unprognostic (1.41e-6)" "unprognostic (6.52e-2)" "unprognostic (1.31e-1)" "unprognostic (1.07e-1)" "unprognostic (8.15e-2)" "unprognostic (9.88e-2)" "unprognostic (1.55e-1)" "unprognostic (1.11e-1)" "unprognostic (1.75e-1)" "unprognostic (1.04e-1)" "unprognostic (4.82e-2)" "unprognostic (1.78e-1)" "unprognostic (1.37e-3)" "unprognostic (4.88e-4)" 1.0 0.6 4.7 0.8 18.7 0.7 3.2 40.6 12.8 1.8 0.0 3.2 1.4 2.2 0.9 1.9 1.3 1.7 0.3 7.0 5.1 1.3 1.6 0.3 1.9 5.0 14.4 0.7 0.3 0.2 1.0 0.2 5.5 1.7 0.5 4.2 2.2 2.7 4.9 4.8 0.7 0.7 0.9 1.9 0.6 10.8 12.0 0.7 7.0 10.3 1.7 1.5 1.0 4.2 0.0 0.0 8.4 0.1 0.2 0.0 0.0 6.6 0.1 0.3 0.1 0.1 0.0 1.1 1.6 3.4 0.6 0.1 5.5 0.0 1.2 63.9 0.8 4.8 0.0 0.0 0.0 0.0 35.5 0.1 0.0 0.1 0.0 0.3 0.2 0.5 0.0 0.3 4.7 0.2 0.0 0.3 2.4 1.2 0.1 0.0 0.9 0.2 16.5 0.0 1.1 0.2 0.0 0.1 0.0 1.1 0.1 0.7 0.5 1.1 3.4 0.7 7.9 0.1 0.0 0.2 0.3 0.0 0.1 0.1 0.0 0.4 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 24.0 0.0 0.0 23.3 0.0 0.2 4.7 18.7 40.6 12.8 7.0 5.1 5.0 14.4 5.5 0.9 12.0 4.2 1.9 0.0 0.0 198.8 1.0 3.7 0.0 0.0 0.0 1.9 0.8 12.3 1.6 0.0 0.0 0.0 10.4 0.0 53.7 0.0 0.0 0.8 42.2 0.1 0.5 2.8 0.0 0.0 47.9 0.4 0.1 0.4 0.0 0.1 0.0 3.3 0.4 7.0 0.4 0.0 44.3 0.0 0.0 0.0 0.8 41.2 0.6 0.8 1.8 8.4 0.1 16.9 0.0 77.9 5.6 0.9 0.0 0.0 0.0 0.1 0.0 0.1 0.0 1.5 0.0 3.3 0.8 0.5 1.6 0.0 5.8 0.0 0.2 3.0 0.3 0.2 EPHB2 "DRT, EPHT3, ERK, Hek5, Tyro5" ENSG00000133216 "EPH receptor B2" P29323 1 22710839-22921500 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" Neurogenesis "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 23.3" "Cell type enhanced" "Detected in many" "Ductal cells: 45.1;Enteroendocrine cells: 48.7;Intestinal goblet cells: 61.1;Oligodendrocytes: 76.3;Pancreatic endocrine cells: 63.7;Undifferentiated cells: 97.2" "Cancer enhanced" "Detected in many" "colorectal cancer: 23.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "GAMG: 86.5;HUVEC TERT2: 74.2;TIME: 79.2;U-251 MG: 69.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB013647, HPA071200" Approved Supported "Nucleoplasm,Plasma membrane" "Intracellular and membrane" No No 380000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 9: Intestine - Unknown function" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane" Nucleoplasm "CAB013647: , HPA071200: AB_2686360" "unprognostic (2.47e-2)" "unprognostic (2.43e-2)" "prognostic favorable (4.98e-4)" "prognostic unfavorable (1.05e-5)" "unprognostic (3.99e-2)" "unprognostic (8.91e-3)" "unprognostic (1.23e-1)" "unprognostic (2.33e-3)" "unprognostic (1.56e-1)" "unprognostic (7.73e-2)" "unprognostic (1.23e-2)" "unprognostic (2.15e-2)" "unprognostic (2.16e-4)" "unprognostic (1.45e-1)" "unprognostic (8.07e-2)" "unprognostic (2.58e-1)" "unprognostic (3.46e-2)" 3.1 1.6 2.1 9.2 3.7 0.5 1.6 4.1 4.2 2.5 0.0 22.6 21.0 1.8 1.9 0.6 4.4 3.7 3.3 2.2 4.3 3.8 0.4 1.8 2.9 5.7 4.5 10.6 3.9 6.1 2.9 4.0 4.8 1.9 23.3 2.9 1.5 3.0 0.2 0.9 21.8 3.3 5.0 2.4 1.7 1.8 5.4 1.2 7.3 0.3 1.7 4.4 1.0 8.2 43.4 17.2 17.2 27.7 1.6 1.5 0.0 10.0 0.5 27.3 5.7 6.3 16.6 0.6 20.2 4.0 86.5 39.6 10.8 52.8 7.7 0.1 4.1 0.0 1.9 0.1 16.5 0.0 4.3 5.3 17.5 48.7 0.3 25.4 74.2 2.4 1.8 0.1 5.7 6.4 1.1 0.3 4.0 49.0 11.2 5.3 18.0 0.8 14.7 4.0 18.0 19.3 17.4 0.7 0.2 1.5 1.1 0.5 79.2 11.5 29.6 29.4 69.5 0.0 0.2 0.1 21.8 0.9 0.5 0.1 0.4 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.1 3.7 4.1 4.2 2.2 4.3 5.7 4.5 4.8 5.0 5.4 8.2 0.4 3.2 0.0 5.5 0.3 0.8 1.7 20.5 0.0 15.4 0.1 0.1 1.3 7.2 8.6 0.0 0.0 0.5 0.1 24.3 0.0 45.1 2.6 1.0 0.8 1.2 48.7 0.0 34.1 8.0 2.8 5.0 1.1 2.4 0.0 0.5 0.4 0.4 9.6 6.7 32.3 61.1 6.1 7.6 1.4 0.8 0.9 7.2 0.0 21.5 0.7 18.4 0.0 5.5 76.3 63.7 12.6 0.7 0.3 2.3 5.5 0.2 1.7 1.8 0.0 0.6 2.1 0.5 3.5 0.0 0.4 1.1 0.3 0.2 97.2 1.1 EPHB3 "ETK2, Hek2, Tyro6" ENSG00000182580 "EPH receptor B3" P54753 3 184561785-184582408 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted membrane proteins" "Angiogenesis, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skin 1: 51.5" "Cell type enhanced" "Detected in many" "Breast glandular cells: 38.1;Breast myoepithelial cells: 50.8;Enteroendocrine cells: 71.5;Intestinal goblet cells: 43.3;Squamous epithelial cells: 44.3;Undifferentiated cells: 55.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 28.8;HaCaT: 40.2;OE19: 28.3;SK-BR-3: 30.9;T-47d: 20.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA007698, HPA008184, CAB034350" Enhanced NA NA 100000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 28: BEWO - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB034350: AB_2262377, HPA007698: AB_1848205, HPA008184: AB_1848206" "unprognostic (2.94e-2)" "unprognostic (5.88e-2)" "unprognostic (2.17e-2)" "unprognostic (7.80e-2)" "unprognostic (1.52e-1)" "unprognostic (9.19e-2)" "unprognostic (8.35e-2)" "unprognostic (1.94e-1)" "unprognostic (5.51e-2)" "unprognostic (1.76e-1)" "unprognostic (7.42e-2)" "unprognostic (3.31e-1)" "prognostic unfavorable (7.88e-5)" "unprognostic (8.83e-3)" "unprognostic (3.03e-2)" "unprognostic (9.59e-3)" "unprognostic (2.10e-3)" 1.7 0.7 3.0 3.7 2.7 0.1 10.4 5.8 4.1 22.7 1.0 10.3 6.4 10.1 1.8 30.6 4.0 2.8 1.9 2.9 2.4 5.8 0.9 3.4 0.9 5.7 3.4 8.3 14.9 1.1 2.0 5.7 6.1 10.0 10.9 0.5 31.7 3.5 0.5 51.5 6.3 3.8 2.3 1.0 22.8 0.9 4.0 0.7 0.9 0.4 2.4 4.0 20.9 2.7 6.6 2.3 14.8 1.6 4.5 0.3 28.8 1.1 1.9 2.2 1.2 2.0 0.2 0.0 2.8 6.3 1.0 40.2 5.4 1.9 0.6 0.2 1.1 0.0 0.3 0.0 0.3 0.0 0.2 1.2 13.0 1.8 0.2 0.7 0.0 0.0 0.0 0.0 1.0 17.6 0.0 6.4 1.4 28.3 2.5 1.5 9.0 0.0 0.0 5.8 1.9 2.2 1.2 30.9 1.3 7.8 20.5 0.1 0.0 3.6 5.1 1.8 2.5 0.0 0.0 0.1 0.3 0.0 14.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 2.7 5.8 4.1 2.9 2.4 5.7 3.4 6.1 2.3 4.0 2.7 0.9 3.2 2.7 11.1 0.2 24.1 7.6 5.3 17.1 0.9 38.1 50.8 1.8 2.8 4.6 0.0 0.0 10.1 1.1 21.5 1.9 0.5 0.6 3.7 4.0 1.4 71.5 0.0 4.6 1.6 18.7 6.9 27.0 7.5 4.5 2.1 1.8 0.0 23.5 15.2 5.8 43.3 10.2 0.3 9.8 0.4 2.8 2.4 0.0 1.0 0.8 0.1 0.0 5.0 0.3 3.2 7.2 6.0 0.0 6.0 1.7 0.2 1.4 1.0 0.0 4.5 2.9 0.4 0.6 44.3 35.8 16.3 0.8 1.6 55.0 20.7 EPHB4 "HTK, Tyro11" ENSG00000196411 "EPH receptor B4" P54760 7 100802565-100827523 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Angiogenesis "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 68.5;Hepatic stellate cells: 113.2;Syncytiotrophoblasts: 206.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "classical monocyte: 2.0;neutrophil: 4.3" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" CAB013537 Uncertain NA NA 1400000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 72: Non-specific - Transcription" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" "CAB013537: " "prognostic unfavorable (8.56e-4)" "unprognostic (1.05e-2)" "prognostic unfavorable (4.33e-4)" "unprognostic (1.33e-1)" "unprognostic (5.23e-2)" "unprognostic (3.43e-2)" "unprognostic (1.46e-1)" "unprognostic (1.01e-1)" "unprognostic (2.73e-1)" "unprognostic (1.84e-1)" "unprognostic (8.16e-3)" "unprognostic (1.43e-1)" "unprognostic (9.51e-3)" "unprognostic (6.63e-2)" "unprognostic (3.13e-1)" "unprognostic (2.07e-2)" "prognostic unfavorable (8.84e-4)" 26.4 49.8 5.0 8.0 4.3 5.6 32.6 4.6 4.8 45.6 6.8 20.7 8.3 61.5 3.8 24.7 27.1 18.0 26.1 4.1 4.1 28.3 33.3 28.2 5.8 5.5 5.1 36.0 26.8 10.1 6.3 35.5 5.3 28.9 10.2 0.3 24.2 22.4 7.7 35.8 17.5 22.2 5.1 47.9 21.4 12.3 6.3 3.1 17.6 13.3 4.9 17.3 28.1 4.8 37.7 33.1 32.5 94.2 20.4 13.0 94.7 14.1 31.2 22.3 29.0 27.4 28.3 4.8 63.6 15.3 31.3 38.2 14.3 38.3 11.9 6.2 25.6 1.3 19.0 43.2 11.8 0.7 0.9 15.3 56.7 14.2 33.1 24.8 84.0 1.5 71.9 1.8 18.4 66.4 0.7 15.0 54.7 56.3 47.5 51.4 15.6 8.9 28.6 19.9 0.2 27.4 22.0 10.4 22.1 45.1 26.1 6.7 71.3 27.6 42.6 51.3 21.4 0.2 0.8 1.7 4.0 12.0 51.2 0.0 2.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 4.3 0.0 0.1 0.1 0.0 0.7 5.0 4.3 4.6 4.8 4.1 4.1 5.5 5.1 5.3 5.1 6.3 4.8 47.1 9.6 12.6 1.6 1.9 20.5 10.3 13.9 15.9 0.1 22.0 19.7 5.7 7.2 8.5 5.5 0.0 68.5 1.1 9.1 0.0 12.3 28.5 4.8 21.8 51.2 3.0 10.8 0.3 6.6 11.2 6.5 12.8 8.0 1.3 10.7 113.2 22.4 9.0 0.0 0.2 17.4 8.2 4.1 3.4 9.9 8.1 1.3 3.6 1.9 1.5 1.7 0.0 0.0 1.0 20.6 7.6 4.1 1.4 13.3 1.3 4.0 4.2 0.2 6.6 5.7 6.3 1.4 10.2 12.1 17.8 206.5 1.2 2.9 19.9 8.0 EPHB6 HEP ENSG00000106123 "EPH receptor B6" 7 142855061-142871094 "Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in many" "brain: 66.0;skin 1: 65.8" "Cell type enhanced" "Detected in many" "Muller glia cells: 226.6;Sertoli cells: 105.2;Suprabasal keratinocytes: 118.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Group enriched" "Detected in many" 6 "MOLT-4: 39.6;RT4: 71.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA035784 Uncertain "Nuclear speckles" "Intracellular and membrane" NA NA "Cluster 30: Non-specific - Translation" "Cluster 27: Brain & Skin - Unknown function" "Cluster 15: RT4 - Unknown function" "Cluster 5: Muller glia cells - Visual perception" "Nuclear speckles" "HPA035784: AB_2674781" "unprognostic (1.90e-2)" "prognostic favorable (1.80e-4)" "unprognostic (7.08e-3)" "unprognostic (2.95e-2)" "prognostic unfavorable (4.10e-4)" "unprognostic (2.53e-3)" "unprognostic (3.15e-2)" "unprognostic (4.39e-1)" "unprognostic (1.78e-1)" "unprognostic (4.69e-2)" "unprognostic (1.06e-3)" "unprognostic (3.18e-1)" "unprognostic (1.69e-1)" "unprognostic (1.21e-1)" "unprognostic (4.93e-2)" "unprognostic (3.16e-1)" "prognostic favorable (4.68e-5)" 9.2 0.7 26.9 1.8 42.0 2.2 3.6 9.7 66.0 18.6 9.2 2.6 0.0 8.9 2.3 10.6 13.5 1.5 3.2 27.7 14.4 4.0 1.5 4.0 2.3 12.9 14.1 7.9 12.4 0.9 2.4 0.4 12.9 14.3 0.1 2.8 5.7 7.3 1.4 65.8 5.0 1.6 12.6 4.3 3.3 5.0 16.7 14.5 9.4 0.7 2.3 7.8 18.5 48.7 0.2 0.0 0.0 0.8 7.5 3.0 0.0 0.9 0.8 0.2 0.1 1.0 2.3 0.0 0.0 0.1 0.0 8.8 0.4 0.0 0.0 2.0 0.3 0.6 0.0 0.3 1.2 9.7 0.4 1.7 0.8 3.0 0.0 0.1 0.5 5.2 2.1 0.0 0.1 0.2 39.6 5.8 6.8 1.4 3.6 0.8 0.0 0.0 0.0 71.7 0.0 0.0 3.3 2.0 0.0 1.5 6.1 0.4 0.0 0.0 2.6 0.0 0.0 0.0 0.6 0.0 0.0 3.5 0.0 0.0 0.8 0.4 0.0 0.3 0.3 1.6 1.1 0.6 0.5 0.3 1.4 0.7 0.5 0.0 0.1 0.0 1.0 0.7 26.9 42.0 9.7 66.0 27.7 14.4 12.9 14.1 12.9 12.6 16.7 48.7 1.9 3.2 1.7 6.2 12.5 54.4 30.7 13.3 42.1 12.1 1.8 6.7 3.0 45.8 10.0 7.3 2.1 0.2 1.9 0.1 5.9 28.2 0.9 5.7 20.0 2.8 1.8 8.6 65.1 6.8 0.0 15.6 6.1 7.2 0.0 3.2 1.8 3.5 4.2 0.0 43.4 0.1 0.0 13.2 10.4 8.3 30.1 8.9 12.4 8.4 7.1 226.6 5.2 5.5 4.6 32.4 0.1 9.8 1.6 11.0 0.0 0.6 4.9 6.6 105.2 31.5 20.5 0.5 7.2 40.0 118.5 0.3 14.0 0.7 0.1 22.2 EPM2A "LD, LDE" ENSG00000112425 "EPM2A glucan phosphatase, laforin" O95278 6 145382535-145736023 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, Carbohydrate metabolism, Glycogen metabolism" "Hydrolase, Protein phosphatase" "Disease variant, Epilepsy, Glycogen storage disease, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 76.8;tongue: 79.5" "Cell type enhanced" "Detected in many" "Astrocytes: 66.9;Early spermatids: 33.0;Excitatory neurons: 30.4;Inhibitory neurons: 50.7;Oligodendrocyte precursor cells: 56.8;Oligodendrocytes: 60.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "NK-cell: 1.9" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "Daudi: 23.2" "Low region specificity" "Detected in all" "HPA053643, HPA055468" Enhanced Nucleoplasm NA NA "Cluster 15: NK-cells - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA053643: AB_2797247, HPA055468: AB_2797252" "unprognostic (2.37e-2)" "unprognostic (1.03e-1)" "unprognostic (1.99e-1)" "unprognostic (3.34e-3)" "unprognostic (2.92e-3)" "unprognostic (1.22e-1)" "unprognostic (2.15e-2)" "unprognostic (1.63e-1)" "unprognostic (2.37e-2)" "unprognostic (1.50e-1)" "unprognostic (1.52e-4)" "unprognostic (2.28e-1)" "prognostic favorable (4.08e-7)" "unprognostic (4.12e-4)" "unprognostic (2.17e-1)" "unprognostic (2.99e-3)" "unprognostic (1.23e-1)" 5.8 6.0 11.4 1.5 11.7 1.8 3.2 11.9 17.8 3.1 7.3 17.2 3.2 6.0 4.3 9.3 4.4 3.6 24.4 11.6 12.6 8.5 5.7 3.0 3.3 11.9 11.5 5.7 2.4 5.2 3.8 1.5 11.1 6.1 2.9 12.1 3.1 8.8 76.8 2.1 3.8 6.3 10.3 2.1 5.3 3.0 11.5 4.8 3.9 79.5 2.6 9.8 2.7 13.3 1.3 2.1 3.4 6.6 8.6 2.3 1.6 3.1 3.8 2.9 3.5 1.7 1.7 23.2 2.7 3.8 3.5 1.8 1.3 1.6 2.6 9.3 1.9 3.6 2.5 2.7 4.8 12.7 2.4 2.0 7.0 1.7 0.7 3.8 2.0 5.0 1.8 5.4 3.8 3.1 8.4 3.2 3.9 3.2 1.9 4.8 3.1 6.7 2.5 1.8 6.3 6.4 5.5 3.3 7.8 3.1 1.9 7.3 4.6 2.9 1.1 2.7 2.6 4.1 4.6 8.6 2.6 2.8 4.8 0.0 0.0 0.0 0.1 0.5 0.4 0.4 0.4 0.3 0.3 0.4 0.4 0.9 0.1 1.9 0.1 0.3 0.0 0.3 11.4 11.7 11.9 17.8 11.6 12.6 11.9 11.5 11.1 10.3 11.5 13.3 3.9 6.4 1.5 66.9 4.4 0.9 1.0 0.8 0.6 8.4 3.5 2.2 27.8 2.8 2.2 1.8 6.2 1.0 1.9 0.2 11.7 1.0 33.0 1.9 3.6 2.2 1.2 4.4 30.4 2.3 0.7 2.3 1.1 1.4 2.5 6.0 1.4 6.6 2.3 30.3 50.7 1.5 2.0 3.3 1.4 19.8 3.1 3.1 7.2 15.9 1.7 7.9 2.1 56.8 60.1 1.2 1.7 2.2 1.7 1.5 0.5 7.1 2.2 6.3 0.0 6.2 2.4 4.9 1.6 0.8 0.4 0.4 1.8 5.1 1.2 0.3 ERBB2 "CD340, HER-2, HER2, NEU, NGL" ENSG00000141736 "Erb-b2 receptor tyrosine kinase 2" P04626 17 39687914-39730426 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Transcription, Transcription regulation" "Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Collecting duct cells: 136.1;Distal enterocytes: 111.0;Proximal enterocytes: 121.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "gdT-cell: 5.0" "Lineage enriched" "Detected in many" 4 "T-cells: 5.0" "Group enriched" "Detected in many" 41 "OE19: 6565.0;SK-BR-3: 3115.9" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB000043, HPA001060, HPA001338, HPA001383, CAB020416, CAB062555" Enhanced Enhanced "Plasma membrane,Cytosol" NA NA 980000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 7: Kidney - Transmembrane transport" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane" Cytosol "CAB000043: AB_2335701, CAB020416: AB_442047, CAB062555: AB_2665610, HPA001060: AB_2666185, HPA001338: AB_2666279, HPA001383: AB_1078500" "unprognostic (1.97e-1)" "unprognostic (6.60e-3)" "unprognostic (6.21e-2)" "prognostic unfavorable (8.99e-8)" "unprognostic (2.96e-2)" "unprognostic (1.40e-2)" "unprognostic (1.97e-2)" "unprognostic (9.04e-2)" "unprognostic (1.79e-2)" "unprognostic (1.20e-3)" "prognostic unfavorable (9.17e-4)" "unprognostic (3.92e-1)" "prognostic favorable (2.41e-14)" "unprognostic (9.29e-2)" "unprognostic (1.40e-1)" "unprognostic (3.75e-2)" "unprognostic (1.96e-1)" 13.0 5.4 16.1 12.1 20.5 1.6 56.0 14.3 13.1 37.6 23.3 68.2 63.6 25.2 26.6 102.4 64.2 31.0 57.0 13.3 16.0 73.5 31.1 36.2 4.8 22.4 22.7 23.9 37.6 81.7 17.3 27.0 17.1 55.6 48.5 8.1 68.7 50.5 20.7 91.0 67.3 25.0 18.5 6.9 49.7 11.7 15.4 7.4 56.5 15.0 28.0 40.0 52.9 16.4 38.7 45.7 50.4 31.7 59.3 41.2 67.7 27.2 44.9 58.6 48.9 34.4 102.7 2.9 54.6 62.7 31.5 117.6 2.8 61.2 26.9 5.2 38.6 1.8 36.0 56.3 35.3 0.9 1.0 41.0 56.6 36.2 21.9 56.2 24.4 1.9 6.2 2.4 43.3 59.4 7.1 3.0 90.7 6565.0 11.7 3.9 20.5 5.4 58.9 118.9 9.4 2.6 51.5 3115.9 16.9 62.2 88.1 2.2 2.9 30.2 37.7 37.7 17.6 5.3 3.3 3.6 3.0 0.9 98.5 1.1 0.2 0.4 5.0 0.1 0.3 0.6 0.2 1.4 0.2 0.6 0.5 1.4 1.2 0.4 0.1 0.1 0.2 1.7 16.1 20.5 14.3 13.1 13.3 16.0 22.4 22.7 17.1 18.5 15.4 16.4 3.9 41.7 40.1 12.7 2.2 14.0 19.0 37.1 17.6 4.6 62.7 34.9 20.7 32.9 43.8 136.1 12.5 12.0 5.1 111.0 7.9 30.9 0.3 48.7 13.9 6.1 15.6 1.3 0.9 25.5 84.8 15.7 53.5 61.3 0.0 20.3 11.7 10.7 4.0 6.7 1.0 47.5 42.7 2.2 3.1 1.0 18.3 1.7 10.6 1.0 1.2 24.1 26.8 2.0 1.0 32.5 54.8 23.0 1.1 34.9 121.7 19.5 42.0 5.8 0.0 13.1 12.7 6.8 5.7 43.5 18.9 22.7 2.8 4.4 75.4 31.3 ERBB3 "HER3, LCCS2" ENSG00000065361 "Erb-b2 receptor tyrosine kinase 3" P21860 12 56076799-56103505 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 254.3;Oligodendrocytes: 187.0;Paneth cells: 184.6;Proximal enterocytes: 240.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "basophil: 2.4;neutrophil: 1.0" "Lineage enriched" "Detected in single" 6 "granulocytes: 2.4" "Cell line enhanced" "Detected in many" "Hep G2: 116.4;OE19: 119.1;RT4: 89.7;SK-BR-3: 106.5;SK-MEL-30: 149.5;T-47d: 122.2;WM-115: 153.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025331, HPA045396, HPA070524" Approved Supported "Plasma membrane,Actin filaments" "Secreted - unknown location" NA NA 450000 "Cluster 17: Basophils - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane" "Actin filaments" "CAB025331: , HPA045396: AB_2679312, HPA070524: " "unprognostic (2.97e-1)" "unprognostic (2.71e-2)" "unprognostic (1.91e-1)" "unprognostic (8.97e-2)" "unprognostic (1.63e-1)" "unprognostic (1.07e-3)" "unprognostic (2.31e-3)" "unprognostic (2.66e-2)" "unprognostic (9.89e-2)" "unprognostic (4.30e-2)" "unprognostic (4.76e-3)" "unprognostic (5.77e-2)" "unprognostic (1.06e-2)" "unprognostic (4.56e-2)" "unprognostic (1.57e-1)" "unprognostic (6.72e-3)" "unprognostic (2.07e-2)" 2.4 2.6 34.4 8.0 69.2 0.9 56.5 45.9 62.0 20.9 10.9 62.9 88.5 5.5 12.3 82.0 12.1 30.6 9.0 39.2 43.1 36.2 98.6 29.3 0.6 59.4 54.4 1.6 57.0 23.8 2.4 13.0 54.7 37.8 64.1 1.3 83.0 18.2 2.4 75.7 82.5 3.8 36.2 0.6 74.7 2.3 55.9 1.0 9.4 1.7 12.5 21.8 44.2 104.9 39.8 2.1 3.2 1.4 0.2 0.1 63.2 3.9 7.2 4.5 4.1 20.4 70.4 0.2 0.8 1.0 0.6 32.2 5.0 7.7 2.3 0.7 3.0 0.1 1.1 116.4 0.1 0.1 0.5 1.3 9.3 0.7 0.3 0.7 0.1 0.8 2.6 1.0 0.4 71.6 0.4 1.3 10.4 119.1 1.9 0.4 7.4 2.1 7.9 89.7 3.3 1.3 2.6 106.5 149.5 9.1 122.2 0.7 0.3 0.5 4.0 1.9 0.5 0.9 0.6 0.6 0.4 0.3 153.4 2.4 0.1 0.3 0.2 0.1 0.1 0.1 0.2 0.1 0.1 0.2 0.2 0.4 1.0 0.4 0.2 0.2 0.3 0.1 34.4 69.2 45.9 62.0 39.2 43.1 59.4 54.4 54.7 36.2 55.9 104.9 0.8 118.6 81.0 1.0 1.5 18.2 15.3 21.6 19.4 1.5 106.4 47.8 1.9 171.6 74.6 35.0 2.1 52.6 2.0 254.3 1.9 60.1 1.3 36.1 10.9 2.7 93.1 2.7 0.7 88.1 84.6 4.5 96.4 95.9 1.3 0.7 5.0 112.0 6.1 0.0 2.0 145.2 40.7 1.9 3.7 0.5 1.5 1.5 55.2 1.0 1.7 7.7 0.0 49.8 187.0 94.8 184.6 0.0 0.3 103.3 240.2 30.0 54.8 1.1 6.6 4.5 3.4 9.5 13.4 87.7 36.9 100.6 2.5 0.1 136.9 135.4 ERBB4 "ALS19, HER4" ENSG00000178568 "Erb-b2 receptor tyrosine kinase 4" Q15303 2 211375717-212538841 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Apoptosis, Lactation, Transcription, Transcription regulation" "Activator, Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Amyotrophic lateral sclerosis, Cancer-related genes, Disease variant, FDA approved drug targets, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 16.9;fallopian tube: 11.2" "Cell type enhanced" "Detected in many" "Astrocytes: 2020.2;Inhibitory neurons: 6091.7;Oligodendrocyte precursor cells: 2369.0;Oligodendrocytes: 1049.9" "Group enriched" "Detected in many" 4 "breast cancer: 4.1;endometrial cancer: 2.1;glioma: 1.2;ovarian cancer: 2.8;testis cancer: 1.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 6.9;EFO-21: 5.1;HEK 293: 3.8;RPTEC TERT1: 5.6;SCLC-21H: 3.1;T-47d: 5.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000276, HPA012016, CAB025522" Enhanced NA NA 220000 "Cluster 57: Non-specific - Angiogenesis" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB000276: , CAB025522: , HPA012016: AB_1846541" "unprognostic (1.48e-1)" "unprognostic (3.28e-1)" "unprognostic (4.31e-3)" "unprognostic (1.76e-3)" "unprognostic (3.59e-1)" "unprognostic (2.75e-1)" "unprognostic (2.88e-1)" "unprognostic (9.56e-2)" "unprognostic (2.07e-1)" "unprognostic (4.67e-3)" "unprognostic (1.07e-1)" "unprognostic (3.61e-1)" "unprognostic (7.14e-3)" "unprognostic (1.49e-3)" "unprognostic (1.41e-1)" "unprognostic (1.14e-1)" "unprognostic (4.11e-2)" 0.3 0.4 10.0 0.0 13.3 0.0 5.6 10.5 11.5 2.9 0.0 0.1 0.0 0.2 0.0 0.1 11.2 0.0 3.0 9.9 12.7 5.1 0.0 0.8 0.0 4.9 16.9 0.1 0.6 3.1 2.4 0.1 7.6 0.3 0.0 2.0 4.7 1.2 1.5 0.3 0.0 0.0 4.3 0.0 0.4 3.3 8.0 0.0 1.6 1.7 0.0 0.1 0.1 6.1 0.0 0.0 6.9 0.2 0.0 0.0 0.0 0.0 0.2 0.3 0.1 0.0 0.0 0.0 5.1 0.7 0.0 0.3 0.2 0.0 0.0 0.1 3.8 0.0 1.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 2.1 0.0 0.0 0.3 0.0 5.6 0.3 3.1 0.2 0.0 0.1 0.1 0.1 5.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.0 13.3 10.5 11.5 9.9 12.7 4.9 16.9 7.6 4.3 8.0 6.1 0.4 0.0 12.6 2020.2 0.0 0.6 0.9 1.1 0.6 15.9 45.6 17.0 27.2 0.0 10.2 12.9 0.0 0.0 0.2 0.0 5.9 0.5 6.7 25.4 1.0 1.0 0.0 0.0 62.0 0.5 0.2 1.8 0.0 25.8 0.0 5.4 0.0 0.0 0.1 0.0 6091.7 0.0 2.0 0.0 0.3 2.2 1.8 0.3 3.6 96.5 0.0 9.1 0.0 2369.0 1049.9 0.0 0.0 0.4 0.0 1.6 0.0 0.2 28.1 1.9 6.6 4.1 3.0 1.8 2.6 0.2 1.3 0.0 0.2 0.0 0.0 1.2 EYA1 BOR ENSG00000104313 "EYA transcriptional coactivator and phosphatase 1" Q99502 8 71197433-71592025 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Transcription, Transcription regulation" "Activator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase" "Deafness, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 18.7;parathyroid gland: 23.7" "Cell type enriched" "Detected in some" 11 "Astrocytes: 214.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AN3-CA: 27.6;RH-30: 21.3;RPMI-8226: 9.5;SH-SY5Y: 51.4" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebellum: 20.7" HPA028917 Supported "Nucleoplasm,Nuclear bodies" NA NA "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 64: Astrocytes - Nervous system maintenance" "Nucleoplasm, Nuclear bodies" "HPA028917: AB_2672826" "unprognostic (3.74e-2)" "unprognostic (1.16e-1)" "unprognostic (1.15e-1)" "unprognostic (1.72e-3)" "unprognostic (5.95e-2)" "unprognostic (9.17e-2)" "unprognostic (2.91e-4)" "unprognostic (1.98e-1)" "unprognostic (1.03e-1)" "unprognostic (1.81e-1)" "unprognostic (9.72e-2)" "unprognostic (1.13e-1)" "unprognostic (4.22e-12)" "unprognostic (1.06e-2)" "unprognostic (1.84e-1)" "unprognostic (3.81e-4)" "unprognostic (1.25e-2)" 0.6 0.6 2.8 0.1 7.8 0.0 0.2 0.5 2.1 5.1 18.7 0.1 0.1 0.1 0.1 0.4 2.0 0.3 4.5 1.3 2.5 0.1 0.0 0.4 0.0 2.1 4.9 0.2 0.0 23.7 10.8 0.0 2.3 12.0 0.2 0.4 0.8 4.0 2.8 0.0 0.2 0.2 0.0 0.1 0.8 0.8 4.6 11.7 0.6 2.5 0.1 2.6 4.3 0.6 0.2 0.0 6.4 27.6 0.0 0.0 0.0 0.2 2.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.9 1.6 0.0 0.0 4.7 0.0 2.2 0.0 0.0 0.5 0.0 6.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 2.0 0.0 1.5 0.0 21.3 9.5 0.0 0.0 2.2 51.4 0.0 0.0 1.6 5.9 0.0 0.1 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 6.3 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 7.8 0.5 2.1 1.3 2.5 2.1 4.9 2.3 0.0 4.6 0.6 0.2 0.0 0.0 214.5 0.0 0.1 0.0 6.4 0.6 0.1 0.0 0.1 8.8 0.0 7.5 0.0 0.0 0.8 0.0 0.0 0.0 0.0 4.4 3.1 0.1 0.2 0.0 0.0 1.3 0.0 0.5 1.3 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 13.5 0.0 2.0 0.0 0.0 6.4 0.3 0.0 0.0 11.2 0.0 0.1 0.0 18.6 0.6 0.0 0.0 0.4 0.0 0.1 0.0 0.3 10.5 0.2 0.0 0.2 0.5 0.8 1.0 1.1 0.1 0.5 0.0 1.4 0.0 0.1 EYA2 EAB1 ENSG00000064655 "EYA transcriptional coactivator and phosphatase 2" O00167 20 46894624-47188844 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Transcription, Transcription regulation" "Activator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "cervix: 55.6" "Cell type enhanced" "Detected in many" "Astrocytes: 153.8;Basal prostatic cells: 47.5;Basal respiratory cells: 50.4;Endometrial ciliated cells: 43.7;Glandular and luminal cells: 53.8;Oligodendrocyte precursor cells: 48.7" "Cancer enhanced" "Detected in many" "endometrial cancer: 69.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HBEC3-KT: 40.1;SCLC-21H: 58.3;U-266/70: 110.9;U-266/84: 139.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA027024, HPA059291" Uncertain Supported Cytosol NA NA "Cluster 57: Non-specific - Angiogenesis" "Cluster 29: U-266 - Adaptive immune response" "Cluster 64: Astrocytes - Nervous system maintenance" Cytosol "HPA027024: AB_1848334, HPA059291: AB_2683967" "unprognostic (1.08e-1)" "unprognostic (5.71e-3)" "unprognostic (4.03e-1)" "prognostic favorable (4.30e-5)" "unprognostic (3.32e-2)" "unprognostic (1.72e-1)" "unprognostic (4.94e-3)" "unprognostic (1.10e-1)" "unprognostic (1.21e-1)" "unprognostic (1.21e-1)" "unprognostic (2.54e-1)" "unprognostic (2.65e-1)" "unprognostic (7.06e-2)" "unprognostic (2.15e-1)" "unprognostic (2.78e-1)" "unprognostic (4.17e-3)" "unprognostic (1.56e-1)" 12.0 1.5 12.3 2.4 14.1 0.0 11.0 15.6 12.3 55.6 11.2 9.3 0.3 17.2 3.7 34.2 34.0 1.8 5.0 10.7 11.8 4.7 2.1 2.2 0.8 14.6 14.4 0.7 1.9 9.4 5.3 6.3 13.7 23.6 3.1 1.2 31.2 9.3 2.5 5.3 1.1 1.8 11.8 0.6 8.9 5.6 13.4 18.8 14.6 3.4 6.6 4.9 16.5 11.0 0.2 4.4 0.2 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.5 0.0 0.0 0.0 1.7 2.5 1.9 0.3 40.1 0.0 0.0 8.1 0.0 0.1 0.0 0.0 0.1 0.3 2.1 4.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 1.3 7.7 0.1 0.0 0.6 0.1 0.0 0.1 0.8 0.5 0.0 0.0 58.3 0.0 0.0 24.8 0.0 3.0 5.3 0.2 0.0 0.0 4.5 0.3 8.8 110.9 139.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.3 14.1 15.6 12.3 10.7 11.8 14.6 14.4 13.7 11.8 13.4 11.0 0.4 0.0 0.0 153.8 0.9 0.6 47.5 50.4 14.8 0.4 7.8 7.6 0.5 2.8 33.0 0.0 6.2 27.7 0.0 2.5 0.0 0.9 0.2 43.7 3.9 0.6 1.2 0.0 1.5 0.0 3.0 4.8 9.2 53.8 1.3 9.8 0.4 3.3 7.4 0.0 5.1 0.6 34.6 0.0 0.4 0.3 0.0 1.1 3.6 13.1 2.6 0.0 0.0 48.7 1.0 1.1 1.7 0.7 3.4 10.9 0.0 6.3 22.2 0.4 0.0 0.3 2.8 0.2 7.4 16.0 0.3 10.8 0.6 4.2 3.6 34.6 EYA3 DKFZp686C132 ENSG00000158161 "EYA transcriptional coactivator and phosphatase 3" Q99504 1 27970344-28088637 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Transcription, Transcription regulation" "Activator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 80.2;Oligodendrocytes: 80.5;Spermatocytes: 98.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA052432, HPA062889" Uncertain Supported Nucleoplasm Yes No "Cluster 49: Eosinophils - Unknown function" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Nucleoplasm "HPA052432: AB_2681831, HPA062889: AB_2684895" "unprognostic (3.57e-1)" "unprognostic (2.61e-1)" "unprognostic (2.85e-1)" "unprognostic (8.74e-2)" "unprognostic (1.39e-1)" "prognostic favorable (5.11e-4)" "unprognostic (1.39e-3)" "unprognostic (2.21e-1)" "unprognostic (4.81e-2)" "unprognostic (1.00e-1)" "unprognostic (9.13e-2)" "unprognostic (8.98e-2)" "prognostic favorable (3.15e-6)" "unprognostic (5.17e-2)" "unprognostic (2.79e-1)" "unprognostic (7.60e-2)" "unprognostic (6.11e-2)" 4.7 4.8 7.4 8.2 7.0 5.2 7.1 8.8 7.9 7.4 9.6 5.7 5.9 6.1 6.4 9.9 6.2 4.3 6.4 6.5 7.6 11.6 6.0 5.9 9.4 7.1 7.1 6.4 6.5 8.3 7.6 7.7 7.2 6.1 6.2 10.5 5.6 5.4 7.1 9.0 6.3 5.5 6.4 7.2 5.5 11.4 7.6 9.4 9.3 8.3 14.4 7.1 6.1 7.9 16.3 6.6 13.1 9.7 14.9 11.6 7.3 11.8 11.0 13.2 12.9 6.4 9.5 25.5 12.3 7.8 4.9 15.3 24.4 9.5 15.6 13.4 13.5 28.2 14.4 11.6 8.8 27.9 25.2 7.0 8.3 14.6 9.7 11.3 17.0 9.0 26.9 9.6 11.9 7.0 18.0 18.5 27.5 12.6 8.6 13.2 24.9 16.8 15.3 8.8 14.9 8.2 12.6 7.6 11.0 10.5 6.2 7.3 16.6 15.9 8.4 15.1 9.4 13.9 15.2 22.0 11.5 26.7 7.0 5.7 6.8 7.3 7.5 6.9 6.7 5.2 5.8 5.4 8.3 4.6 4.9 5.6 6.4 7.1 6.1 5.1 5.4 1.9 7.4 7.0 8.8 7.9 6.5 7.6 7.1 7.1 7.2 6.4 7.6 7.9 12.6 9.6 10.8 46.4 17.5 17.8 11.3 10.0 9.6 18.3 12.0 7.1 9.2 12.8 7.9 25.8 16.7 13.0 10.6 8.2 15.6 13.5 80.2 13.6 13.2 12.9 20.4 9.9 66.0 8.9 14.4 11.6 16.8 15.3 12.0 15.8 14.6 8.7 9.7 18.5 58.8 9.1 12.2 13.3 46.1 39.1 10.2 14.6 12.4 39.4 12.9 8.1 10.3 45.2 80.5 14.5 10.9 6.0 13.7 12.0 13.8 18.0 5.7 20.6 13.1 11.1 8.4 98.7 50.6 10.7 22.9 10.9 15.8 9.6 10.5 11.7 EYA4 "CMD1J, DFNA10" ENSG00000112319 "EYA transcriptional coactivator and phosphatase 4" O95677 6 133240598-133532128 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Transcription, Transcription regulation" "Activator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase" "Cardiomyopathy, Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 27.6;tongue: 21.3" "Cell type enhanced" "Detected in many" "Collecting duct cells: 46.0;Inhibitory neurons: 139.0;Oligodendrocytes: 79.2;Skeletal myocytes: 26.2" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 25.4;GAMG: 25.6;HeLa: 74.3;RH-30: 23.8;U-87 MG: 24.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA004805, HPA038771, HPA038772" Enhanced Approved Nucleoplasm No NA "Cluster 80: Striated muscle - Unknown function" "Cluster 20: HeLa - Mitochondria" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA004805: AB_10669750, HPA038771: AB_10671865, HPA038772: AB_10673119" "unprognostic (1.60e-1)" "unprognostic (3.34e-1)" "unprognostic (1.27e-1)" "unprognostic (2.04e-9)" "unprognostic (1.64e-1)" "unprognostic (3.08e-2)" "unprognostic (3.44e-2)" "unprognostic (7.21e-2)" "unprognostic (9.07e-2)" "unprognostic (2.04e-2)" "unprognostic (2.80e-1)" "unprognostic (2.29e-1)" "unprognostic (8.27e-4)" "unprognostic (1.82e-3)" "unprognostic (6.67e-2)" "unprognostic (9.55e-2)" "unprognostic (2.51e-2)" 1.1 2.5 2.6 0.1 1.9 0.0 0.4 2.2 1.9 2.6 13.3 0.2 0.2 0.5 1.2 0.4 7.4 0.5 5.8 2.3 1.2 5.0 0.0 1.8 0.1 5.6 7.9 1.2 0.2 0.0 0.8 0.0 4.5 5.7 0.2 0.1 0.2 11.8 27.6 0.0 0.1 0.3 4.5 0.4 0.4 3.0 3.3 6.6 2.1 21.3 0.5 2.2 2.3 4.9 0.0 25.4 2.4 0.0 0.0 0.0 0.0 0.0 20.4 0.5 2.9 0.1 0.1 0.1 19.6 0.0 25.6 0.0 15.4 6.7 0.0 0.0 20.2 2.8 74.3 0.0 0.6 0.0 6.8 5.1 0.0 14.4 4.5 3.4 0.0 0.0 0.0 10.7 8.1 0.0 0.0 0.0 0.0 0.3 1.6 0.3 23.8 0.0 0.0 3.9 3.7 4.1 0.2 0.0 11.4 0.1 0.0 0.0 0.0 0.0 0.0 0.1 18.4 7.2 3.4 0.0 24.6 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 1.9 2.2 1.9 2.3 1.2 5.6 7.9 4.5 4.5 3.3 4.9 0.3 12.8 1.8 2.6 0.0 0.1 0.1 13.3 0.0 0.0 0.0 0.0 14.4 0.0 6.7 46.0 0.0 0.0 0.0 0.1 0.0 0.1 4.4 0.1 0.1 0.5 1.8 0.0 4.8 0.2 0.0 2.9 0.0 0.1 0.0 1.5 0.4 0.1 0.0 0.0 139.0 0.0 8.2 1.0 0.0 2.6 0.6 0.2 0.0 2.8 7.2 0.0 0.0 1.5 79.2 0.0 0.0 0.0 0.0 0.2 0.0 0.2 4.8 0.0 0.0 26.2 3.3 7.9 7.1 0.0 0.0 0.0 0.1 1.5 0.0 0.2 FER "PPP1R74, TYK3" ENSG00000151422 "FER tyrosine kinase" P16591 5 108747841-109196841 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in all" 6 "Alveolar cells type 1: 80.1;Astrocytes: 207.3;Early spermatids: 158.1;Excitatory neurons: 266.3;granulocytes: 95.5;Inhibitory neurons: 313.8;Late spermatids: 182.4;Microglial cells: 227.7;Oligodendrocyte precursor cells: 284.0;Oligodendrocytes: 216.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in many" 5 "RPMI-8226: 91.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007641, CAB022464" Approved Supported Cytosol NA NA "Cluster 37: B-cells - Transcription" "Cluster 21: Non-specific - Transcription" "Cluster 25: RPMI-8226 - Immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "CAB022464: , HPA007641: AB_1078845" "unprognostic (1.72e-1)" "unprognostic (1.66e-2)" "unprognostic (1.74e-1)" "unprognostic (2.46e-3)" "unprognostic (4.72e-2)" "unprognostic (5.65e-2)" "unprognostic (6.81e-2)" "unprognostic (7.39e-2)" "unprognostic (1.05e-1)" "unprognostic (8.36e-3)" "unprognostic (7.36e-2)" "unprognostic (8.05e-2)" "prognostic favorable (5.55e-4)" "unprognostic (3.83e-3)" "unprognostic (3.22e-1)" "unprognostic (1.03e-1)" "unprognostic (3.99e-3)" 4.2 3.7 3.4 3.0 3.2 1.6 3.6 2.8 3.4 3.8 0.6 3.9 1.7 3.7 2.9 4.2 3.0 3.3 3.0 3.1 3.9 3.5 2.3 3.7 1.4 3.6 3.7 4.6 1.9 9.4 2.5 4.2 3.8 3.0 2.4 5.7 2.5 3.9 1.3 4.5 2.0 4.9 4.1 2.7 2.2 6.7 3.1 2.8 6.4 2.0 2.0 3.5 3.2 5.0 9.8 3.4 11.0 18.0 6.6 10.1 7.2 11.4 11.0 6.5 7.6 19.0 5.5 15.3 6.9 13.8 8.4 6.3 6.2 14.4 14.7 6.5 8.4 9.8 14.5 7.0 4.4 5.6 8.2 6.2 7.9 15.8 17.5 6.4 9.8 14.6 12.9 11.1 8.4 2.7 4.4 1.7 1.6 0.9 7.0 3.3 10.7 91.7 6.4 3.3 3.8 5.6 18.6 1.0 11.4 7.0 4.4 2.4 14.7 12.5 10.2 6.5 9.0 9.4 14.9 5.9 7.4 1.9 6.0 8.9 3.7 4.6 1.2 2.5 2.1 10.3 0.7 1.4 2.3 3.4 1.2 1.5 0.3 1.1 2.0 4.5 1.7 0.9 3.4 3.2 2.8 3.4 3.1 3.9 3.6 3.7 3.8 4.1 3.1 5.0 23.8 80.1 28.3 207.3 9.5 29.2 15.8 9.5 25.6 17.6 6.6 8.5 21.9 10.0 21.8 14.7 18.8 3.9 7.5 4.9 1.9 13.6 158.1 13.1 17.2 19.7 8.4 10.7 266.3 6.0 10.7 31.4 16.8 12.6 95.5 21.8 18.9 2.3 8.2 18.5 313.8 4.5 8.2 9.5 13.4 182.4 19.3 14.1 14.2 227.7 12.0 10.5 4.1 284.0 216.0 9.1 4.7 17.7 13.7 12.1 1.7 6.9 27.9 16.3 6.6 30.7 23.8 7.7 11.5 13.2 17.6 3.1 10.4 10.2 4.1 6.9 FES FPS ENSG00000182511 "FES proto-oncogene, tyrosine kinase" P07332 15 90883695-90895776 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Proto-oncogene, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 83.4;lymphoid tissue: 110.9" "Cell type enhanced" "Detected in many" "Adipocytes: 46.8;Hofbauer cells: 48.7;Kupffer cells: 92.3;Macrophages: 51.9;monocytes: 57.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 315.8" "Group enriched" "Detected in many" 4 "dendritic cells: 162.6;granulocytes: 315.8;monocytes: 151.7" "Cell line enhanced" "Detected in many" "HEL: 63.5;HL-60: 56.9;HMC-1: 116.6;NB-4: 76.1;THP-1: 110.8;U-937: 48.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA001376 Approved Approved Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 2: Immune cells - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Cytosol" Vesicles "HPA001376: AB_1078847" "unprognostic (1.07e-2)" "unprognostic (2.54e-2)" "prognostic unfavorable (5.78e-4)" "unprognostic (2.31e-2)" "unprognostic (4.05e-3)" "unprognostic (7.33e-2)" "unprognostic (1.74e-1)" "unprognostic (2.22e-1)" "unprognostic (1.58e-3)" "unprognostic (1.35e-1)" "unprognostic (4.66e-2)" "unprognostic (5.15e-3)" "unprognostic (1.78e-3)" "unprognostic (2.53e-3)" "unprognostic (6.08e-2)" "unprognostic (1.18e-1)" "unprognostic (1.40e-1)" 30.8 8.0 9.4 20.2 8.8 83.4 21.3 9.6 10.8 18.1 9.6 12.5 5.8 15.7 2.4 5.9 19.0 14.0 19.6 8.3 8.7 18.9 25.2 30.9 13.8 11.1 9.2 13.5 7.8 2.3 5.6 16.3 10.1 17.9 4.6 1.5 58.3 8.0 6.1 8.0 12.5 10.7 10.4 110.9 9.6 4.5 10.9 4.2 16.0 7.0 5.7 15.1 13.5 9.8 0.4 0.8 0.8 10.3 3.1 8.8 17.9 2.9 0.1 5.1 2.9 2.6 0.1 6.8 0.5 6.0 0.2 1.5 1.7 0.3 1.6 3.3 1.1 63.5 0.0 11.9 6.8 56.9 116.6 8.8 0.1 7.6 0.0 0.0 31.2 9.4 1.8 0.2 0.0 21.3 1.8 76.1 3.2 2.5 0.0 8.6 0.1 0.1 0.0 0.2 0.4 0.1 0.0 2.8 2.3 2.9 0.1 110.8 24.9 0.2 10.4 0.2 0.2 0.1 8.0 2.5 0.3 48.0 2.4 64.4 151.7 315.8 0.5 88.6 0.4 5.2 0.3 0.4 162.6 4.1 0.2 0.3 100.5 51.4 39.8 65.0 0.2 81.5 9.4 8.8 9.6 10.8 8.3 8.7 11.1 9.2 10.1 10.4 10.9 9.8 46.8 3.2 5.8 3.6 5.0 3.8 5.4 0.5 0.6 0.2 4.1 3.8 3.4 8.6 0.5 1.8 0.0 5.3 25.6 0.6 3.9 7.3 1.7 2.0 4.2 29.1 3.0 8.0 2.8 4.3 4.2 9.0 2.0 4.2 29.2 10.7 20.0 15.0 48.7 0.0 0.2 2.0 2.0 92.3 27.9 8.4 9.0 51.9 7.2 5.6 57.8 2.5 26.8 2.0 0.3 2.1 2.0 10.1 4.0 3.1 0.7 1.5 0.2 1.9 13.1 4.6 12.9 4.4 15.9 1.0 2.8 4.5 6.7 3.3 3.7 5.2 FGFR1 "BFGFR, CD331, CEK, FLG, FLT2, H2, H3, H4, H5, KAL2, N-SAM" ENSG00000077782 "Fibroblast growth factor receptor 1" P11362 8 38400215-38468834 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins, Transporters" "Transcription, Transcription regulation" "Heparin-binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Craniosynostosis, Disease variant, Dwarfism, FDA approved drug targets, Holoprosencephaly, Hypogonadotropic hypogonadism, Kallmann syndrome, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Fibroblasts: 176.7;Leydig cells: 192.0;Oligodendrocyte precursor cells: 166.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "AN3-CA: 508.7;BJ hTERT+: 278.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033614, HPA056402" Approved NA NA 78000000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 89: Fibroblasts - ECM organization" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 50: Fibroblasts - ECM organization" "CAB033614: AB_783377, HPA056402: AB_2683118" "unprognostic (9.53e-2)" "unprognostic (7.33e-2)" "unprognostic (2.44e-1)" "unprognostic (1.35e-2)" "unprognostic (4.23e-3)" "unprognostic (7.02e-2)" "unprognostic (6.59e-2)" "unprognostic (2.77e-1)" "unprognostic (1.81e-1)" "unprognostic (3.99e-2)" "unprognostic (7.97e-3)" "unprognostic (4.59e-2)" "unprognostic (7.69e-2)" "unprognostic (6.87e-3)" "unprognostic (5.60e-2)" "unprognostic (4.59e-3)" "unprognostic (1.05e-3)" 95.1 12.8 27.5 15.9 24.6 14.1 87.1 48.8 22.4 79.8 37.2 97.2 8.8 74.2 15.8 35.8 85.9 57.1 89.9 30.9 28.8 40.1 9.1 55.7 16.6 35.9 37.3 108.2 98.6 20.4 57.1 51.3 63.7 60.5 17.9 15.8 31.4 53.6 24.8 35.6 41.7 57.1 30.3 9.9 40.4 20.4 33.4 17.1 33.7 23.3 16.1 79.3 63.9 29.6 12.9 42.0 198.0 508.7 120.1 91.2 142.9 136.7 278.8 90.0 95.8 27.3 6.5 1.8 38.3 127.7 103.9 0.2 90.0 6.8 104.3 39.2 24.1 0.0 7.7 27.8 69.7 31.1 0.6 80.5 0.7 70.9 13.3 45.6 86.9 6.0 11.9 0.4 40.5 12.5 91.5 9.2 145.9 1.6 21.6 86.3 21.1 0.4 35.6 0.3 7.9 19.4 23.4 1.0 5.1 93.4 9.3 5.4 51.4 49.2 28.9 149.6 29.7 2.4 4.1 0.5 60.3 1.7 27.1 0.2 0.3 0.1 1.7 0.1 1.1 0.3 0.7 1.2 0.0 0.6 0.5 1.5 0.6 0.4 0.2 0.2 1.0 0.1 27.5 24.6 48.8 22.4 30.9 28.8 35.9 37.3 63.7 30.3 33.4 29.6 101.0 3.2 15.8 55.8 1.8 31.5 95.9 1.1 37.0 4.4 28.7 77.7 52.5 24.3 5.1 9.2 4.2 8.3 6.3 0.4 0.0 27.3 15.3 48.2 40.6 75.5 25.0 3.6 25.4 65.2 80.5 176.7 3.1 75.3 8.2 40.4 47.5 0.8 25.3 21.9 21.1 0.6 4.1 5.6 75.2 15.0 192.0 11.7 33.8 19.7 1.7 88.1 6.2 166.4 14.2 21.6 0.3 99.6 6.4 94.7 0.1 7.9 1.0 3.3 13.1 118.9 59.9 1.6 14.1 4.8 19.7 10.4 14.1 2.1 0.7 11.7 FGFR2 "BEK, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25" ENSG00000066468 "Fibroblast growth factor receptor 2" P21802 10 121478332-121598458 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" Apoptosis "Heparin-binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Craniosynostosis, Disease variant, Ectodermal dysplasia, FDA approved drug targets, Lacrimo-auriculo-dento-digital syndrome, Mental retardation, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 273.8;choroid plexus: 198.1" "Group enriched" "Detected in many" 5 "Astrocytes: 228.2;Cholangiocytes: 213.1;Oligodendrocytes: 562.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 24 "basophil: 13.2;eosinophil: 3.8" "Lineage enriched" "Detected in single" 58 "granulocytes: 13.2" "Cell line enhanced" "Detected in many" "AN3-CA: 189.0;BEWO: 60.9;CACO-2: 49.6;HaCaT: 55.6;HAP1: 63.7;NTERA-2: 57.8;T-47d: 49.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010886, HPA035305" Uncertain Supported "Nucleoplasm,Vesicles,Cell Junctions" "Secreted - unknown location" NA NA 1200000 "Cluster 34: Basophils - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Cell Junctions" "Nucleoplasm, Vesicles" "CAB010886: AB_259379, HPA035305: AB_10672862" "unprognostic (5.53e-2)" "prognostic favorable (8.79e-4)" "unprognostic (1.08e-1)" "unprognostic (5.23e-2)" "unprognostic (1.73e-1)" "prognostic favorable (9.32e-4)" "unprognostic (1.53e-1)" "unprognostic (4.96e-3)" "unprognostic (1.74e-1)" "unprognostic (1.56e-1)" "unprognostic (1.07e-1)" "unprognostic (3.74e-2)" "unprognostic (1.01e-1)" "unprognostic (6.11e-2)" "unprognostic (2.54e-1)" "unprognostic (6.93e-2)" "unprognostic (2.25e-1)" 5.7 21.3 103.9 8.2 186.8 0.3 22.9 178.9 198.9 19.7 198.1 44.8 10.4 54.6 15.3 25.2 29.6 31.3 5.6 109.9 124.7 26.3 41.0 30.9 2.9 250.9 185.9 18.0 31.0 61.0 6.8 15.7 220.5 27.4 21.2 1.2 59.1 54.6 0.5 109.3 12.2 43.6 165.5 0.8 22.5 7.6 148.0 10.1 54.6 0.2 9.1 16.6 27.4 273.8 7.2 0.4 30.2 189.0 0.1 0.0 60.9 0.4 0.0 0.0 0.0 49.6 1.1 0.1 12.5 2.8 0.1 55.6 63.7 13.0 0.0 0.1 12.7 0.0 0.2 1.2 1.5 0.2 11.7 0.1 26.2 0.0 0.6 0.0 0.0 0.3 0.2 0.2 0.0 11.7 0.2 0.1 57.8 8.7 0.0 0.1 0.0 7.5 18.0 15.8 0.5 0.5 0.4 33.4 0.0 36.6 49.3 0.0 0.1 0.3 8.5 0.2 0.7 0.1 0.1 0.0 0.3 0.0 0.5 13.2 0.0 3.8 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 103.9 186.8 178.9 198.9 109.9 124.7 250.9 185.9 220.5 165.5 148.0 273.8 1.4 19.2 36.0 228.2 0.6 40.1 34.3 18.4 58.6 0.2 8.7 25.4 9.1 213.1 38.4 36.8 0.0 16.5 0.3 7.3 0.0 7.4 4.1 28.1 4.4 1.0 2.4 2.7 14.8 0.2 3.0 9.0 13.3 53.1 0.0 0.1 1.8 5.0 2.3 0.0 31.2 40.8 10.2 0.6 4.4 9.6 1.2 1.1 5.4 10.3 0.6 2.0 1.0 6.0 562.5 0.7 3.0 6.0 0.1 15.0 1.8 13.6 15.3 0.2 0.0 1.6 2.6 0.7 9.9 18.7 27.7 4.0 1.5 0.4 3.8 31.4 FGFR3 "ACH, CD333, CEK2, JTK4" ENSG00000068078 "Fibroblast growth factor receptor 3" P22607 4 1793293-1808872 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" Apoptosis "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Craniosynostosis, Deafness, Disease variant, Dwarfism, Ectodermal dysplasia, FDA approved drug targets, Lacrimo-auriculo-dento-digital syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 148.3;esophagus: 139.7;skin 1: 271.5" "Cell type enhanced" "Detected in many" "Astrocytes: 410.4;Basal keratinocytes: 103.8;Cholangiocytes: 91.5;Suprabasal keratinocytes: 88.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CACO-2: 48.2;HaCaT: 34.9;Hep G2: 80.6;NTERA-2: 36.1;RT4: 64.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004231, HPA067204" Enhanced Supported "Endoplasmic reticulum" "Secreted - unknown location" NA NA 2500000 "Cluster 27: Brain & Skin - Unknown function" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 64: Astrocytes - Nervous system maintenance" "Endoplasmic reticulum" "CAB004231: AB_627596, HPA067204: AB_2685804" "unprognostic (1.34e-1)" "unprognostic (5.29e-3)" "unprognostic (1.49e-1)" "prognostic unfavorable (3.77e-4)" "unprognostic (5.90e-2)" "unprognostic (1.24e-3)" "unprognostic (7.22e-2)" "unprognostic (2.54e-1)" "unprognostic (1.99e-1)" "unprognostic (2.17e-1)" "unprognostic (1.38e-1)" "unprognostic (2.88e-2)" "unprognostic (1.30e-1)" "unprognostic (9.11e-3)" "unprognostic (1.98e-1)" "unprognostic (4.74e-2)" "unprognostic (1.97e-1)" 1.6 1.6 118.0 1.5 140.6 1.4 5.5 115.6 104.0 23.7 37.4 12.2 19.5 1.5 2.8 139.7 2.2 7.9 4.8 100.8 107.6 39.3 40.7 7.4 0.4 144.7 129.2 0.5 76.4 0.2 16.1 9.3 109.8 13.8 5.2 0.2 20.2 15.0 1.3 271.5 14.7 0.4 108.9 4.0 7.8 17.6 148.3 1.7 1.5 0.9 11.1 23.1 60.9 81.2 0.0 3.8 19.5 5.6 0.0 0.3 22.1 2.4 0.3 0.8 0.4 48.2 1.0 0.0 17.8 0.7 0.7 34.9 5.5 0.3 0.3 0.2 19.3 14.2 3.9 80.6 0.1 0.0 0.6 0.0 10.9 0.2 0.1 0.1 0.1 2.3 16.7 0.1 0.0 23.9 0.8 0.5 36.1 19.5 0.1 1.2 1.0 0.3 2.8 64.1 5.7 1.6 1.9 4.0 0.0 22.2 20.4 2.5 1.0 0.0 2.1 0.5 1.6 0.1 0.0 0.0 0.2 1.7 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 118.0 140.6 115.6 104.0 100.8 107.6 144.7 129.2 109.8 108.9 148.3 81.2 2.2 0.0 32.5 410.4 1.1 103.8 4.1 29.8 23.9 0.0 4.8 1.5 3.1 91.5 37.6 14.7 0.0 0.5 1.6 36.1 0.0 5.0 7.9 3.0 1.7 3.4 4.2 0.0 0.5 0.7 12.0 3.2 3.6 4.0 0.0 0.1 16.1 30.4 0.6 0.0 1.3 20.7 4.1 1.2 6.5 1.3 0.6 0.6 12.4 14.0 0.6 0.1 0.0 34.2 2.2 0.4 18.0 0.4 0.0 4.2 21.2 9.9 9.8 0.6 0.0 0.7 2.9 0.4 25.9 55.0 88.7 0.8 0.7 0.1 17.0 12.8 FGFR4 "CD334, JTK2" ENSG00000160867 "Fibroblast growth factor receptor 4" P22455 5 177086905-177098144 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins, Transporters" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 82.5;lung: 65.4" "Cell type enhanced" "Detected in many" "Cholangiocytes: 78.6;Hepatocytes: 31.2;Skeletal myocytes: 141.2;Theca cells: 36.7;Undifferentiated cells: 38.6" "Cancer enhanced" "Detected in many" "liver cancer: 42.0" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 4 "CACO-2: 173.9;Hep G2: 176.4;RH-30: 274.3" "Not detected" "Not detected" "Low region specificity" "Detected in many" "CAB005196, HPA027273, HPA027369, HPA028251" Approved "Intracellular and membrane" NA NA 7400000 "Cluster 18: Non-specific - Mitochondria" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 50: Fibroblasts - ECM organization" "CAB005196: AB_631512, HPA027273: AB_10600212, HPA027369: AB_10599427, HPA028251: AB_10601221" "unprognostic (1.96e-1)" "unprognostic (2.10e-2)" "unprognostic (1.12e-1)" "unprognostic (9.06e-3)" "unprognostic (2.87e-1)" "unprognostic (1.95e-2)" "unprognostic (7.85e-3)" "unprognostic (9.19e-2)" "unprognostic (4.25e-1)" "unprognostic (4.46e-2)" "unprognostic (1.16e-1)" "unprognostic (3.48e-2)" "unprognostic (1.78e-1)" "unprognostic (1.71e-3)" "unprognostic (2.41e-1)" "unprognostic (5.75e-2)" "unprognostic (4.68e-2)" 1.2 14.0 1.1 4.1 1.1 0.5 4.5 2.7 2.1 3.0 1.2 18.0 21.3 2.4 0.2 3.2 4.2 10.2 2.2 1.4 1.0 40.2 82.5 65.4 0.8 0.7 0.8 27.5 29.5 0.2 2.0 2.1 0.9 5.2 6.0 1.5 1.1 0.7 6.6 1.7 20.0 1.1 0.7 22.7 8.8 5.9 1.1 0.2 0.9 1.9 0.2 6.4 3.2 1.3 3.2 48.8 1.0 11.7 0.1 0.1 24.5 0.2 0.1 0.2 0.3 173.9 6.5 5.3 23.0 0.1 2.4 2.8 9.5 1.8 0.1 3.2 13.8 0.5 2.8 176.4 5.2 0.6 4.7 1.1 0.2 8.4 0.2 0.3 0.2 3.5 18.1 0.7 3.9 40.3 0.1 3.6 29.2 30.9 4.5 8.2 274.3 30.9 22.9 0.4 1.8 2.9 1.8 12.4 5.9 5.9 11.7 2.5 1.1 0.0 23.4 0.3 0.7 1.6 1.9 3.7 0.1 1.1 2.0 0.2 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 1.1 1.1 2.7 2.1 1.4 1.0 0.7 0.8 0.9 0.7 1.1 1.3 0.3 0.0 0.0 0.3 0.3 0.6 0.7 0.4 0.0 0.9 2.9 2.0 0.9 78.6 0.1 3.7 0.0 1.3 0.1 12.9 3.9 10.9 0.1 1.6 0.3 0.7 4.2 0.0 0.5 4.9 3.8 9.6 9.7 2.9 0.0 0.7 3.9 31.2 0.3 0.0 0.5 10.1 0.0 0.9 0.5 0.0 0.6 0.7 0.0 1.9 0.6 0.6 0.0 0.5 0.1 3.0 4.4 1.5 0.1 1.7 15.9 21.6 0.1 0.4 19.7 141.2 0.7 3.0 9.9 0.8 0.4 8.8 0.4 36.7 38.6 0.5 FGR "c-fgr, p55c-fgr, SRC2" ENSG00000000938 "FGR proto-oncogene, Src family tyrosine kinase" P09769 1 27612064-27635185 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Immunity, Innate immunity" "Kinase, Transferase, Tyrosine-protein kinase" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "bone marrow: 207.8;lung: 86.5;lymphoid tissue: 141.1" "Cell type enhanced" "Detected in many" "Kupffer cells: 182.2;Langerhans cells: 63.8;Macrophages: 155.9;monocytes: 159.7;NK-cells: 259.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Group enriched" "Detected in some" 4 "Daudi: 86.0;U-266/70: 153.1" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA002024 Enhanced Approved "Plasma membrane,Aggresome" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 29: U-266 - Adaptive immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "Plasma membrane" Aggresome "HPA002024: AB_1078503" "unprognostic (2.66e-2)" "unprognostic (1.51e-2)" "unprognostic (6.32e-2)" "unprognostic (9.74e-3)" "unprognostic (6.66e-3)" "unprognostic (6.71e-2)" "unprognostic (5.77e-2)" "unprognostic (1.25e-1)" "unprognostic (1.81e-2)" "unprognostic (7.45e-2)" "unprognostic (2.79e-2)" "unprognostic (1.10e-1)" "unprognostic (1.94e-2)" "unprognostic (6.26e-2)" "unprognostic (3.93e-2)" "unprognostic (2.30e-1)" "unprognostic (8.12e-3)" 25.0 6.8 12.8 62.2 11.9 207.8 16.0 11.9 19.1 7.6 11.5 6.0 3.9 8.1 1.7 5.2 15.6 12.7 8.7 11.4 12.3 7.5 10.8 86.5 27.5 13.6 12.7 2.9 5.8 1.6 2.7 7.9 14.5 7.2 4.0 0.7 6.6 2.4 3.2 4.5 10.1 16.3 12.5 141.1 5.9 2.5 17.2 8.4 7.4 6.5 20.0 17.8 7.3 12.6 0.0 0.0 0.3 0.0 0.5 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 86.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.7 0.0 0.0 0.0 1.7 29.3 0.3 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.3 0.0 0.0 3.8 5.2 0.1 0.0 0.0 0.1 0.0 0.1 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.2 0.0 0.0 0.0 0.0 0.0 153.1 2.1 6.5 0.0 19.5 0.0 30.8 381.4 229.4 189.5 469.1 11.3 54.0 15.8 89.1 196.1 84.0 8.0 78.4 272.9 264.5 405.2 9.0 1.2 494.1 12.8 11.9 11.9 19.1 11.4 12.3 13.6 12.7 14.5 12.5 17.2 12.6 8.6 6.4 20.0 0.0 24.9 2.8 0.6 0.2 0.0 0.0 0.4 0.6 1.6 1.5 5.7 1.8 0.0 0.5 55.2 0.0 0.0 0.0 0.3 0.1 0.2 14.9 0.0 7.4 0.2 0.2 0.7 2.7 1.5 0.1 13.3 0.1 6.8 1.9 56.8 0.0 0.1 0.0 0.0 182.2 63.8 0.7 0.3 155.9 1.8 6.5 159.7 0.1 259.5 1.0 0.4 0.0 1.2 0.0 4.2 0.4 0.0 0.7 1.5 0.0 0.0 0.7 0.6 0.2 0.5 0.5 1.1 1.0 28.0 0.0 0.0 2.5 FLT1 "FLT, VEGFR1" ENSG00000102755 "Fms related receptor tyrosine kinase 1" P17948 13 28300346-28495145 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" "Angiogenesis, Chemotaxis, Differentiation" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 7 "placenta: 432.4" "Cell type enhanced" "Detected in many" "Adipocytes: 411.6;Endothelial cells: 263.1;Extravillous trophoblasts: 815.4;Hepatic stellate cells: 234.9;Microglial cells: 433.8;Syncytiotrophoblasts: 1127.1" "Cancer enhanced" "Detected in all" "renal cancer: 28.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ: 71.8;BJ hTERT+: 57.2;HMC-1: 349.2;HUVEC TERT2: 64.9;WM-115: 127.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA011740, HPA014290, CAB068189, CAB068190" Enhanced Supported "Plasma membrane,Actin filaments" "Secreted to blood" NA NA 876000 87000 "Cluster 21: B-cells - Adaptive immune response" "Cluster 28: Placenta - Pregnancy" "Cluster 3: HMC-1 - Innate immune response" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" "Plasma membrane" "Actin filaments" "CAB068189: AB_2665636, CAB068190: AB_2665637, HPA011740: AB_1858737, HPA014290: AB_1858738" "unprognostic (3.33e-2)" "unprognostic (3.52e-3)" "unprognostic (1.13e-3)" "unprognostic (5.02e-2)" "unprognostic (3.65e-1)" "unprognostic (5.03e-2)" "unprognostic (8.25e-2)" "unprognostic (2.27e-3)" "unprognostic (9.91e-2)" "unprognostic (6.61e-2)" "unprognostic (2.33e-1)" "unprognostic (1.57e-1)" "prognostic unfavorable (2.19e-4)" "unprognostic (4.20e-2)" "unprognostic (6.00e-2)" "unprognostic (1.57e-1)" "unprognostic (6.32e-2)" 47.6 9.6 37.6 9.1 36.2 1.1 31.2 37.0 43.0 16.4 24.6 9.4 7.5 17.2 3.7 5.9 11.7 16.6 46.0 33.3 39.8 34.9 18.2 25.8 5.3 44.6 40.0 4.4 12.7 30.5 9.0 432.4 50.1 13.9 6.1 52.5 7.0 11.0 19.9 5.9 9.3 17.4 33.4 18.6 10.9 17.4 59.6 3.6 48.9 38.8 5.7 14.0 9.5 38.7 0.1 0.0 0.0 0.6 0.6 0.9 0.3 71.8 57.2 25.8 14.9 0.0 0.2 0.1 0.1 9.6 0.0 0.3 6.7 0.0 45.4 0.0 2.0 0.2 0.1 0.0 0.1 0.0 349.2 0.6 0.0 0.1 1.0 0.1 64.9 6.1 1.7 0.3 0.0 0.3 4.5 3.7 37.5 0.0 0.1 2.9 0.0 0.1 0.1 0.1 8.1 0.6 0.0 0.1 0.2 44.4 0.3 0.2 6.3 0.2 1.2 0.1 0.1 2.1 1.0 0.2 0.4 0.3 127.8 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.8 0.1 0.1 0.5 0.0 0.0 0.1 0.0 0.0 37.6 36.2 37.0 43.0 33.3 39.8 44.6 40.0 50.1 33.4 59.6 38.7 411.6 0.0 6.0 2.0 4.7 4.1 0.7 0.2 3.4 17.8 1.2 1.5 26.5 2.8 2.9 0.0 4.2 197.2 1.4 0.1 1.9 0.6 157.2 0.5 1.5 263.1 0.0 0.0 0.9 0.0 815.4 32.1 0.5 2.1 1.3 0.1 234.9 6.9 30.8 1.7 14.5 0.0 0.0 12.5 23.6 173.8 18.6 15.3 0.0 433.8 0.0 153.2 0.0 9.5 2.0 0.0 0.0 48.5 4.1 1.3 0.0 0.1 1.8 9.7 92.1 11.4 30.1 14.6 4.6 1.0 4.8 1127.1 2.8 1.5 0.0 1.1 FLT3 "CD135, FLK2, STK1" ENSG00000122025 "Fms related receptor tyrosine kinase 3" P36888 13 28003274-28100592 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, RAS pathway related proteins" "Host-virus interaction" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 5.3;brain: 4.9;lymphoid tissue: 6.5" "Cell type enhanced" "Detected in some" "dendritic cells: 24.4;Inhibitory neurons: 59.9;Kupffer cells: 29.1;Langerhans cells: 21.4;Macrophages: 16.9;monocytes: 39.5" "Cancer enhanced" "Detected in some" "breast cancer: 1.8" "Region enhanced" "Detected in some" "cerebellum: 4.9" "Group enriched" "Detected in many" 13 "myeloid DC: 68.7;plasmacytoid DC: 26.2" "Lineage enriched" "Detected in many" 19 "dendritic cells: 68.7" "Group enriched" "Detected in some" 11 "REH: 42.5;THP-1: 26.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA047539 Approved "Endoplasmic reticulum" NA NA 210000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 14: REH - Unknown function" "Cluster 41: Macrophages - Immune response" "Endoplasmic reticulum" "HPA047539: AB_2680080" "unprognostic (2.19e-3)" "unprognostic (3.16e-3)" "unprognostic (6.54e-3)" "unprognostic (9.96e-2)" "unprognostic (3.88e-1)" "unprognostic (3.96e-7)" "unprognostic (7.99e-3)" "unprognostic (1.65e-2)" "unprognostic (5.37e-2)" "unprognostic (1.01e-2)" "unprognostic (1.96e-1)" "unprognostic (1.03e-1)" "unprognostic (4.56e-2)" "unprognostic (3.65e-1)" "unprognostic (3.91e-2)" "unprognostic (2.51e-1)" "unprognostic (2.22e-1)" 0.5 0.1 0.3 3.0 0.2 5.3 1.5 4.9 0.8 0.5 0.1 0.7 0.3 0.2 0.1 0.6 0.4 1.6 0.1 0.2 0.5 1.5 0.5 0.7 6.5 1.3 0.9 0.1 2.8 0.0 0.0 0.0 1.7 0.1 0.8 0.0 0.4 0.2 0.0 0.7 1.6 0.8 0.8 5.7 0.6 0.6 0.8 4.7 0.1 0.3 3.6 1.3 0.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 3.2 0.6 0.0 0.0 42.5 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 26.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 3.6 3.4 0.0 0.8 0.0 0.2 0.0 0.0 68.7 0.0 0.0 0.0 0.1 2.0 0.0 26.2 0.0 2.7 0.3 0.2 4.9 0.8 0.2 0.5 1.3 0.9 1.7 0.8 0.8 0.8 0.0 0.0 0.0 2.3 1.5 0.3 0.0 0.0 0.0 0.0 1.5 1.0 0.4 1.5 0.0 0.0 0.0 0.0 24.4 0.0 0.0 2.7 3.7 0.3 0.1 0.2 0.0 8.2 7.4 0.0 0.0 0.2 0.0 1.1 0.0 0.0 0.7 0.1 0.5 0.0 59.9 0.0 0.0 29.1 21.4 2.3 0.0 16.9 1.8 1.9 39.5 0.0 0.0 1.5 4.2 0.1 0.0 0.0 2.2 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.1 0.2 0.6 0.0 0.6 0.0 1.7 0.0 0.0 0.0 FLT4 "PCL, VEGFR-3, VEGFR3" ENSG00000037280 "Fms related receptor tyrosine kinase 4" P35916 5 180601506-180649624 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" Angiogenesis "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in some" 7 "Adipocytes: 27.4;Endothelial cells: 27.1;Extravillous trophoblasts: 37.1;Hepatic stellate cells: 64.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 4 "MAIT T-cell: 3.8" "Lineage enriched" "Detected in single" 31 "T-cells: 3.8" "Cell line enhanced" "Detected in some" "AN3-CA: 10.1;BEWO: 12.4;HEK 293: 15.6;HL-60: 9.5;HUVEC TERT2: 9.9;JURKAT: 12.3;T-47d: 14.6;TIME: 15.7" "Low region specificity" "Detected in many" "Not detected" "Not detected" "CAB000099, HPA046519, HPA067906, HPA074389" Approved Supported "Nuclear speckles,Plasma membrane,Cell Junctions" "Secreted to blood" NA NA 20000000 290000000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 6: T47d - Mammary gland" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Nuclear speckles, Plasma membrane" "Cell Junctions" "CAB000099: , HPA046519: AB_2732527, HPA067906: AB_2732775, HPA074389: " "unprognostic (7.35e-2)" "unprognostic (1.63e-1)" "unprognostic (9.45e-3)" "unprognostic (3.81e-1)" "unprognostic (9.26e-2)" "unprognostic (3.20e-3)" "unprognostic (1.13e-2)" "unprognostic (1.80e-2)" "unprognostic (2.19e-1)" "unprognostic (1.70e-1)" "unprognostic (2.13e-2)" "unprognostic (3.69e-1)" "unprognostic (1.88e-2)" "unprognostic (9.41e-3)" "unprognostic (1.83e-1)" "unprognostic (8.26e-2)" "unprognostic (1.32e-1)" 17.2 11.3 3.5 4.7 4.6 0.8 14.7 2.6 3.4 9.0 2.6 4.9 2.8 8.0 3.0 4.4 9.8 3.8 9.7 5.1 2.6 20.1 6.2 16.9 5.5 3.4 3.0 4.5 2.0 2.3 7.8 6.4 3.6 5.6 1.3 0.3 2.0 2.5 4.7 4.0 7.2 4.1 2.8 17.6 3.5 3.1 4.2 1.0 25.7 4.1 1.4 5.6 5.5 2.7 0.1 2.5 3.2 10.1 0.0 0.0 12.4 0.3 0.1 0.0 0.0 0.4 0.3 0.3 0.9 0.1 0.6 0.4 3.4 0.2 0.3 0.1 15.6 1.2 0.5 0.5 0.1 9.5 0.3 0.2 0.1 0.2 0.4 0.3 9.9 12.3 0.4 0.4 2.1 5.6 0.1 0.5 7.0 0.3 0.6 8.2 0.1 0.1 0.1 0.3 0.3 1.1 0.1 0.2 0.1 3.1 14.6 0.3 15.7 0.2 6.9 0.2 0.1 0.2 0.1 0.1 0.1 0.2 0.1 0.1 0.0 0.0 0.5 0.0 3.8 0.0 0.2 0.8 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 3.5 4.6 2.6 3.4 5.1 2.6 3.4 3.0 3.6 2.8 4.2 2.7 27.4 0.0 1.7 0.7 0.7 0.9 0.2 0.0 1.2 0.2 1.4 1.4 4.5 0.0 0.6 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.4 0.1 0.1 27.1 0.0 0.0 0.2 0.0 37.1 0.8 0.0 0.1 2.5 2.4 64.6 0.6 1.2 0.0 0.1 0.0 0.0 3.3 0.8 0.7 0.3 0.6 0.0 3.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.8 0.0 0.2 0.0 0.7 0.7 0.1 5.2 0.1 1.1 1.0 1.8 0.2 0.0 0.1 FRK "GTK, PTK5, RAK" ENSG00000111816 "Fyn related Src family tyrosine kinase" P42685 6 115931149-116060891 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "FDA approved drug targets, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 13.7" "Cell type enhanced" "Detected in many" "Early spermatids: 89.4;Oligodendrocytes: 97.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "OE19: 18.3;RT4: 7.6" "Not detected" "Not detected" "Not detected" "Not detected" "CAB025217, HPA030479, HPA072590" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 17: Basophils - Unknown function" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 21: OE19 - Mitochondria" "Cluster 44: Endometrium - Transcription" Nucleoplasm Cytosol "CAB025217: , HPA030479: AB_2732457, HPA072590: " "unprognostic (7.70e-3)" "unprognostic (1.99e-2)" "unprognostic (1.11e-1)" "unprognostic (4.68e-3)" "unprognostic (1.96e-1)" "unprognostic (3.49e-2)" "unprognostic (2.09e-1)" "unprognostic (1.58e-1)" "unprognostic (4.23e-2)" "unprognostic (5.82e-3)" "unprognostic (1.45e-1)" "unprognostic (7.54e-2)" "prognostic favorable (9.66e-7)" "unprognostic (1.52e-2)" "unprognostic (1.34e-1)" "unprognostic (2.02e-2)" "unprognostic (1.10e-1)" 0.8 1.1 1.3 1.2 2.1 1.5 2.4 5.8 5.0 1.8 13.7 4.6 6.2 1.0 2.5 2.9 2.6 2.6 1.8 1.8 0.0 9.0 6.8 1.8 0.7 0.3 0.1 0.9 2.8 1.0 0.4 0.8 1.0 2.2 4.8 2.9 4.0 2.4 2.2 1.9 6.3 0.8 0.2 0.9 4.9 1.9 1.1 1.2 1.0 0.8 1.6 2.1 1.0 5.7 2.5 4.0 0.5 0.9 0.2 0.2 0.6 0.5 0.1 0.0 0.1 3.1 3.8 0.9 3.5 0.5 0.5 5.8 0.2 1.1 0.1 3.3 0.3 1.3 3.3 2.7 0.2 0.9 0.7 0.2 1.5 0.3 0.4 0.4 0.2 0.6 0.6 2.3 1.0 1.3 0.7 0.5 1.0 18.3 0.7 1.1 3.3 1.2 4.8 7.6 0.7 0.8 0.7 5.1 0.5 0.9 1.5 0.7 0.8 1.0 1.0 0.7 0.5 3.6 2.7 1.6 1.1 0.6 0.6 0.9 0.2 0.2 0.4 0.1 0.5 0.2 0.3 0.4 0.1 0.4 0.2 0.3 0.8 0.3 0.2 0.3 0.2 0.0 1.3 2.1 5.8 5.0 1.8 0.0 0.3 0.1 1.0 0.2 1.1 5.7 0.4 0.0 10.3 10.4 0.5 2.7 20.8 23.3 6.8 0.6 7.3 2.9 9.2 11.5 22.6 23.9 0.0 4.4 0.1 34.9 11.7 20.3 89.4 28.1 1.7 0.7 19.8 0.0 12.2 16.4 4.3 3.5 29.0 30.4 3.8 0.2 1.4 21.9 0.9 6.7 7.7 14.5 34.6 0.6 0.4 38.1 0.6 0.6 0.0 1.0 1.0 0.2 0.0 2.5 97.8 21.9 23.3 1.2 0.5 23.4 49.3 28.4 36.6 0.3 13.1 9.9 16.2 4.6 1.0 16.4 3.1 0.8 1.0 2.3 19.1 46.2 FRMPD2 "MGC35285, PDZD5C, PDZK5C" ENSG00000170324 "FERM and PDZ domain containing 2" Q68DX3 10 48153088-48274696 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 6.7;choroid plexus: 5.2;retina: 24.9" "Cell type enhanced" "Detected in some" "Bipolar cells: 50.0;Cone photoreceptor cells: 287.7;Early spermatids: 97.7;Endometrial ciliated cells: 70.6;Late spermatids: 118.5;Respiratory ciliated cells: 62.9;Rod photoreceptor cells: 90.8" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 2.4;HBEC3-KT: 1.0;SCLC-21H: 1.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" NA NA "Cluster 77: Retina - Visual perception" "Cluster 28: BEWO - Transcription regulation" "Cluster 9: Photoreceptor cells - Phototransduction" "unprognostic (1.53e-1)" "unprognostic (3.08e-1)" "unprognostic (7.88e-4)" "unprognostic (7.59e-2)" "unprognostic (2.37e-1)" "unprognostic (2.06e-1)" "unprognostic (6.54e-3)" "unprognostic (1.85e-1)" "unprognostic (6.60e-2)" "unprognostic (1.12e-1)" "unprognostic (3.25e-12)" "unprognostic (3.48e-2)" "unprognostic (5.43e-2)" "unprognostic (1.54e-1)" "unprognostic (7.43e-5)" 0.0 0.0 2.4 0.0 2.0 0.0 0.4 2.7 1.3 0.2 5.2 0.0 0.0 0.1 0.1 0.0 3.0 0.0 0.9 2.1 2.7 0.1 0.0 0.2 0.0 4.7 6.7 0.0 0.0 0.0 0.1 0.0 4.1 0.3 0.1 24.9 0.0 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.3 3.5 0.0 0.5 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.3 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.0 0.0 0.0 0.8 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 2.0 2.7 1.3 2.1 2.7 4.7 6.7 4.1 4.0 3.5 3.4 0.0 0.0 0.5 36.6 0.0 0.1 0.4 1.6 0.0 50.0 1.1 0.4 5.0 0.0 4.6 3.7 287.7 0.2 0.0 0.1 0.0 0.1 97.7 70.6 0.5 0.3 3.0 0.0 2.0 0.0 0.3 0.8 0.0 1.6 0.0 0.0 0.0 0.2 0.1 3.3 0.9 0.6 6.1 0.0 0.0 118.5 0.3 0.2 0.0 0.0 0.0 5.2 0.0 0.5 0.3 0.2 0.1 0.4 0.0 0.4 4.2 0.5 62.9 90.8 0.0 0.2 0.6 2.1 1.0 0.0 0.3 0.0 0.1 0.1 0.7 0.4 FYN "MGC45350, SLK, SYN" ENSG00000010810 "FYN proto-oncogene, Src family tyrosine kinase" P06241 6 111660332-111873452 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Adaptive immunity, Host-virus interaction, Immunity" "Developmental protein, Kinase, Transferase, Tyrosine-protein kinase" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 382.6;dendritic cells: 291.6;NK-cells: 228.6;Oligodendrocyte precursor cells: 342.8;Proximal tubular cells: 212.2;T-cells: 275.8" "Cancer enhanced" "Detected in all" "glioma: 42.5" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in all" 16 "NK-cells: 69.0;T-cells: 174.8" "Cell line enhanced" "Detected in many" "U-2197: 538.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005034, CAB018387, HPA023887, HPA063770" Approved Enhanced "Plasma membrane,Cytosol" NA NA 820000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 18: U-2197 - ECM organization" "Cluster 24: Non-specific - Transcription regulation" "Plasma membrane" Cytosol "CAB005034: AB_562117, CAB018387: AB_627642, HPA023887: AB_1849226, HPA063770: AB_2685119" "unprognostic (8.62e-3)" "unprognostic (8.25e-2)" "unprognostic (2.11e-1)" "unprognostic (2.00e-2)" "unprognostic (1.51e-1)" "unprognostic (2.43e-2)" "prognostic favorable (1.84e-4)" "unprognostic (4.60e-2)" "unprognostic (2.89e-2)" "unprognostic (2.92e-1)" "prognostic favorable (4.78e-4)" "unprognostic (1.43e-1)" "prognostic unfavorable (1.43e-4)" "unprognostic (6.95e-2)" "unprognostic (3.10e-1)" "unprognostic (6.62e-3)" "unprognostic (2.40e-1)" 76.6 10.8 117.1 52.4 106.4 32.3 46.8 83.8 104.3 45.5 33.3 32.9 16.4 45.6 33.8 16.0 51.4 32.1 40.5 102.1 121.5 23.9 20.4 63.5 108.9 136.3 104.9 28.8 8.5 18.7 22.9 29.7 107.0 17.6 15.6 26.9 12.9 12.5 12.3 41.5 47.1 38.0 109.9 71.9 29.3 16.5 105.7 86.1 45.7 18.3 67.6 48.4 33.4 109.8 10.4 1.5 178.6 30.2 133.4 81.4 3.2 29.1 90.8 24.2 42.9 1.3 1.6 21.0 18.3 56.1 21.0 1.3 25.8 39.9 46.8 0.7 66.5 57.0 13.6 2.7 78.7 19.5 19.0 78.8 59.1 90.5 76.8 62.9 99.5 99.6 4.9 140.3 86.8 1.5 92.7 17.9 26.0 3.3 18.0 29.1 24.0 1.4 0.0 9.1 124.6 50.7 5.7 2.4 124.7 39.6 1.3 57.0 63.9 72.3 13.5 538.7 18.5 20.0 19.7 32.5 136.0 44.3 128.9 1.1 6.4 0.2 137.0 5.6 174.8 4.8 83.9 152.7 7.4 6.4 27.9 72.3 3.0 69.0 4.2 4.3 79.2 51.5 117.1 106.4 83.8 104.3 102.1 121.5 136.3 104.9 107.0 109.9 105.7 109.8 87.8 0.0 8.3 382.6 26.0 17.1 2.5 0.6 1.8 57.2 2.9 6.9 11.3 14.3 2.1 7.3 0.0 2.7 291.6 1.2 17.6 9.3 3.7 5.6 51.7 70.3 13.2 20.9 118.7 1.0 2.4 61.9 17.9 4.9 52.0 20.9 76.4 60.3 3.0 47.1 127.6 3.8 2.0 35.8 96.1 3.2 26.4 42.7 37.4 88.1 64.5 89.1 228.6 342.8 162.3 9.7 0.1 7.2 96.2 3.9 17.7 212.2 4.4 8.3 13.1 48.8 32.9 3.9 8.6 0.7 13.4 52.0 275.8 71.1 2.9 1.1 HCK JTK9 ENSG00000101336 "HCK proto-oncogene, Src family tyrosine kinase" P08631 20 32052197-32101856 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Exocytosis, Host-virus interaction, Immunity, Inflammatory response, Innate immunity, Phagocytosis" "Kinase, Transferase, Tyrosine-protein kinase" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 112.1" "Cell type enhanced" "Detected in many" "Hofbauer cells: 150.7;Kupffer cells: 155.5;Langerhans cells: 89.2;Macrophages: 170.1;Microglial cells: 52.5;monocytes: 222.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 16 "classical monocyte: 575.0;eosinophil: 707.8;intermediate monocyte: 1059.1;myeloid DC: 336.3;neutrophil: 801.3;non-classical monocyte: 1251.7" "Group enriched" "Detected in all" 16 "dendritic cells: 336.3;granulocytes: 801.3;monocytes: 1251.7" "Group enriched" "Detected in some" 9 "THP-1: 69.3;U-937: 199.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "CAB005195, HPA035534, HPA063768" Approved Supported "Vesicles,Plasma membrane,Cytosol" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 2: Immune cells - Immune response" "Cluster 32: U-937 - Innate immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Vesicles "Plasma membrane, Cytosol" "CAB005195: AB_631619, HPA035534: , HPA063768: AB_2685118" "unprognostic (6.22e-2)" "unprognostic (6.16e-3)" "unprognostic (2.26e-2)" "unprognostic (7.98e-2)" "unprognostic (8.83e-2)" "unprognostic (5.50e-2)" "unprognostic (4.09e-2)" "unprognostic (1.72e-2)" "unprognostic (4.34e-2)" "unprognostic (1.59e-1)" "unprognostic (4.08e-2)" "unprognostic (1.21e-1)" "prognostic unfavorable (1.66e-4)" "unprognostic (4.92e-2)" "unprognostic (4.42e-2)" "unprognostic (6.95e-2)" "unprognostic (1.12e-1)" 24.8 9.2 4.7 100.0 5.0 55.2 6.0 5.5 6.0 5.5 13.7 12.8 15.2 3.1 2.6 6.7 7.6 14.4 4.8 4.7 6.2 4.7 14.1 46.0 38.6 9.9 6.8 2.5 4.5 2.1 3.1 20.9 8.3 4.0 13.6 0.5 5.1 4.7 1.6 5.8 17.8 25.3 8.1 112.1 6.7 2.3 8.4 14.5 2.8 6.9 39.3 32.8 4.1 12.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.9 0.0 0.1 0.1 1.3 0.0 0.0 0.1 0.0 4.3 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 15.6 0.0 0.1 0.1 4.9 0.4 0.0 0.0 0.4 0.2 0.6 0.0 0.0 0.3 0.0 0.5 0.0 0.2 0.7 0.0 69.3 0.0 0.0 0.3 0.0 0.1 1.9 0.3 10.3 0.0 199.6 0.0 6.4 575.0 707.8 1.1 1059.1 1.3 48.4 1.1 1.1 336.3 43.0 1.1 0.9 801.3 11.0 1251.7 30.4 1.2 566.4 4.7 5.0 5.5 6.0 4.7 6.2 9.9 6.8 8.3 8.1 8.4 12.0 0.6 6.4 14.0 0.0 17.1 3.1 4.0 0.2 0.6 0.1 0.4 1.3 2.0 1.5 3.9 7.3 0.0 0.9 12.1 0.2 1.9 0.1 2.5 0.1 0.1 3.7 1.8 1.7 1.2 0.6 0.9 1.3 4.6 0.1 6.3 0.1 1.1 2.3 150.7 0.0 1.0 0.5 22.4 155.5 89.2 0.3 0.0 170.1 1.8 52.5 222.0 0.0 4.1 1.5 0.6 0.0 0.0 0.0 0.7 0.5 0.1 0.3 1.5 0.1 0.0 0.6 0.5 0.2 0.3 0.2 1.1 1.6 3.0 0.2 0.9 3.7 IGF1R "CD221, IGFIR, IGFR, JTK13, MGC18216" ENSG00000140443 "Insulin like growth factor 1 receptor" P08069 15 98648539-98964530 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Host-virus interaction" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 239.4;Inhibitory neurons: 194.6;Microglial cells: 245.4;Oligodendrocyte precursor cells: 237.7;Oligodendrocytes: 261.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 4.3" "Group enriched" "Detected in many" 6 "granulocytes: 4.3;T-cells: 1.4" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010268, HPA045563" Approved NA NA 46000 "Cluster 50: Neutrophils - Cellular senescence" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 20: HeLa - Mitochondria" "Cluster 40: Granulosa cells - Unknown function" "CAB010268: AB_671792, HPA045563: AB_2679368" "unprognostic (1.30e-3)" "unprognostic (5.81e-3)" "unprognostic (1.53e-1)" "unprognostic (3.34e-2)" "unprognostic (2.65e-1)" "unprognostic (2.05e-2)" "unprognostic (1.29e-2)" "unprognostic (6.87e-2)" "unprognostic (2.64e-2)" "unprognostic (2.87e-2)" "unprognostic (8.56e-2)" "unprognostic (1.62e-1)" "prognostic favorable (3.75e-7)" "unprognostic (1.57e-1)" "unprognostic (3.59e-1)" "unprognostic (1.41e-1)" "unprognostic (1.06e-1)" 7.3 11.3 10.1 3.6 11.2 11.0 12.2 12.0 12.0 10.1 35.5 12.5 2.5 11.0 11.1 7.5 13.0 4.5 9.6 9.5 8.2 11.6 0.9 9.5 2.7 12.4 13.4 15.8 15.4 2.1 8.8 12.1 11.2 14.7 4.5 16.0 10.0 9.6 7.0 11.1 6.5 6.1 10.3 5.8 9.6 8.4 13.2 6.1 12.9 11.6 3.4 9.9 10.0 11.1 6.1 34.0 22.6 0.2 11.9 8.3 16.3 8.0 14.5 2.5 2.2 15.6 17.5 1.6 22.1 13.8 14.7 31.6 10.9 25.0 1.9 0.1 11.1 27.5 32.3 31.2 10.4 11.1 2.5 12.1 14.9 4.5 18.6 9.3 8.4 2.8 1.4 5.4 9.9 48.1 5.4 9.8 23.0 11.8 1.3 7.7 19.3 6.7 7.4 37.8 8.1 35.9 56.0 3.3 30.1 50.2 16.7 3.8 24.5 1.5 26.5 6.5 12.0 1.9 9.8 5.9 4.6 10.0 5.9 1.9 0.3 0.9 0.4 0.2 0.2 0.1 0.3 0.1 0.1 0.4 1.4 0.4 4.3 0.5 0.3 0.1 0.0 0.3 10.1 11.2 12.0 12.0 9.5 8.2 12.4 13.4 11.2 10.3 13.2 11.1 30.8 28.9 13.4 157.7 3.5 32.8 28.8 31.1 35.3 51.5 58.3 33.4 30.8 5.7 30.2 22.0 91.8 33.7 8.0 10.7 1.9 16.6 27.6 79.7 39.6 26.1 35.0 7.8 239.4 11.2 20.3 25.2 11.2 91.3 0.0 106.5 52.5 1.5 6.5 75.7 194.6 21.1 20.3 6.6 8.3 53.4 18.0 8.3 21.4 245.4 8.5 45.6 14.4 237.7 261.0 29.1 12.9 13.5 4.3 70.9 5.3 21.8 55.4 36.1 0.0 20.4 27.6 4.0 17.2 17.9 32.0 27.5 6.4 20.9 24.5 51.5 INSL3 "MGC119818, MGC119819, RLF, RLNL" ENSG00000248099 "Insulin like 3" P51460 19 17816512-17821574 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted secreted proteins" Hormone "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 14 "testis: 409.3" "Cell type enriched" "Detected in some" 19 "Theca cells: 24080.8" "Cancer enriched" "Detected in many" 21 "testis cancer: 39.4" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "Karpas-707: 5.7;PC-3: 2.6;SCLC-21H: 5.2;SH-SY5Y: 4.7" HPA028615 Enhanced "Secreted to blood" NA NA 566000 "Cluster 1: Neutrophils - Mixed function" "Cluster 83: Testis - Spermatogenesis" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 52: Non-specific - Transcription" "HPA028615: AB_10600717" "unprognostic (3.25e-1)" "unprognostic (2.25e-4)" "unprognostic (3.50e-5)" "unprognostic (7.04e-2)" "unprognostic (1.74e-4)" "unprognostic (4.60e-2)" "unprognostic (2.03e-1)" "unprognostic (1.58e-2)" "unprognostic (1.44e-1)" "unprognostic (1.73e-1)" "unprognostic (4.46e-1)" "unprognostic (4.93e-2)" "unprognostic (9.51e-10)" "unprognostic (6.80e-3)" "unprognostic (1.41e-1)" "unprognostic (8.85e-2)" "unprognostic (1.09e-5)" 0.5 1.6 1.2 4.8 1.3 1.8 0.5 2.3 1.5 0.1 1.3 0.5 1.5 0.3 0.8 0.6 0.8 0.4 0.2 1.4 1.5 0.5 0.4 0.9 2.9 1.2 1.3 29.6 0.2 0.0 0.2 0.3 1.4 0.6 0.0 0.1 0.6 0.0 0.2 0.3 1.7 0.0 1.2 5.2 0.8 409.3 1.5 0.5 0.3 0.4 1.2 0.4 0.3 1.3 0.2 0.6 0.1 0.5 0.1 0.0 1.2 0.0 0.0 0.0 0.0 0.1 1.1 0.1 1.4 0.0 0.2 0.0 0.0 0.0 0.0 1.2 0.1 0.5 0.0 0.2 0.0 0.0 1.2 0.8 0.6 0.0 0.0 0.0 0.0 0.1 0.0 5.7 0.0 1.0 0.2 1.1 0.0 1.1 2.6 0.9 0.0 0.1 0.1 0.3 5.2 4.7 0.0 1.6 0.0 0.0 0.4 0.0 0.0 0.0 0.0 1.4 0.0 0.4 2.1 0.1 0.1 1.3 0.0 0.4 0.2 0.0 0.7 0.4 0.7 0.0 0.9 0.9 0.1 1.1 0.7 1.0 2.2 0.5 0.1 0.1 0.8 0.5 1.2 1.3 2.3 1.5 1.4 1.5 1.2 1.3 1.4 1.2 1.5 1.3 0.4 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.7 2.3 0.0 0.0 0.1 6.8 0.0 0.1 3.4 0.0 0.0 0.3 0.0 0.4 42.3 0.0 0.0 0.0 0.9 0.4 0.0 0.3 0.0 0.2 0.0 0.0 0.0 0.0 257.1 1240.2 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 998.6 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.1 2.9 5.7 0.0 0.0 0.5 0.8 24080.8 0.0 0.0 INSR CD220 ENSG00000171105 "Insulin receptor" P06213 19 7112255-7294414 "CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Carbohydrate metabolism" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Diabetes mellitus, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in many" 8 "dendritic cells: 9.8;granulocytes: 5.9;monocytes: 12.5" "Cell line enhanced" "Detected in many" "Karpas-707: 54.9;U-266/70: 40.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036302, HPA036303" Uncertain Approved "Vesicles,Plasma membrane" NA Yes 190000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 22: Non-specific - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 52: Non-specific - Transcription" Vesicles "Plasma membrane" "HPA036302: AB_2675048, HPA036303: " "unprognostic (4.64e-2)" "unprognostic (2.42e-1)" "unprognostic (9.65e-3)" "unprognostic (9.70e-2)" "unprognostic (1.44e-1)" "unprognostic (1.15e-2)" "unprognostic (2.58e-1)" "unprognostic (5.09e-2)" "unprognostic (1.97e-1)" "unprognostic (3.05e-1)" "unprognostic (9.29e-2)" "unprognostic (1.86e-1)" "unprognostic (6.33e-2)" "unprognostic (3.45e-3)" "unprognostic (2.43e-1)" "unprognostic (2.75e-1)" "unprognostic (8.82e-2)" 13.0 22.6 12.5 2.8 16.8 5.6 13.0 17.3 12.8 14.6 18.8 15.0 10.0 18.4 6.3 4.1 16.9 8.2 26.3 10.0 12.2 21.8 33.0 7.2 2.3 18.3 16.3 39.9 64.2 13.0 16.3 7.4 18.7 15.2 10.4 6.5 16.9 9.9 23.5 11.5 12.2 11.5 14.1 48.2 12.5 5.4 16.6 2.7 14.5 13.3 3.5 12.3 9.2 22.5 6.2 3.2 3.6 5.7 18.8 6.1 11.1 3.5 2.9 1.6 1.6 8.4 7.0 9.0 8.2 6.8 4.0 1.6 8.9 1.4 1.2 0.0 6.4 0.0 2.3 22.6 8.2 4.3 6.7 10.0 4.5 0.2 4.9 4.2 3.8 4.8 9.5 54.9 1.8 3.2 3.1 7.8 3.3 3.8 5.2 29.0 2.1 7.6 0.1 27.8 6.6 5.2 6.5 3.8 3.3 6.4 1.4 21.6 3.6 3.4 2.1 8.2 5.1 40.4 23.9 20.2 4.3 7.3 0.0 2.7 8.6 5.9 0.2 8.8 0.3 0.8 0.3 0.1 9.8 1.1 0.7 0.1 1.9 1.0 12.5 8.2 0.0 1.6 12.5 16.8 17.3 12.8 10.0 12.2 18.3 16.3 18.7 14.1 16.6 22.5 75.6 48.1 34.7 64.9 10.6 64.9 63.6 34.7 8.0 40.4 134.0 76.2 92.1 137.2 83.3 62.5 79.2 17.8 6.7 124.1 15.6 55.1 4.7 26.8 106.8 123.9 163.6 25.0 68.3 78.7 53.7 43.7 20.4 42.1 3.8 168.4 255.2 246.0 9.2 38.7 100.8 97.3 32.6 49.0 31.1 9.0 96.3 35.0 51.6 62.8 24.2 31.6 0.0 62.8 183.5 50.7 68.8 245.3 21.8 107.9 122.9 114.1 65.3 23.6 59.2 37.6 44.2 5.2 3.6 3.2 68.8 38.3 4.7 81.4 65.2 130.0 INSRR IRR ENSG00000027644 "Insulin receptor related receptor" P14616 1 156840063-156859117 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 14.5;kidney: 3.8" "Cell type enhanced" "Detected in some" "Bipolar cells: 1.9;Cardiomyocytes: 2.3;Early spermatids: 2.8;Spermatocytes: 4.1;Spermatogonia: 5.2" "Not detected" "Not detected" "Group enriched" "Detected in many" 7 "medulla oblongata: 14.5;pons: 13.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "SCLC-21H: 4.6;SH-SY5Y: 15.9" "Not detected" "Not detected" "Not detected" "Not detected" HPA025285 Uncertain NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "HPA025285: AB_1851814" "unprognostic (1.19e-1)" "unprognostic (7.69e-2)" "unprognostic (2.42e-2)" "unprognostic (6.76e-4)" "unprognostic (1.51e-1)" "unprognostic (9.07e-3)" "unprognostic (5.57e-2)" "unprognostic (1.75e-1)" "unprognostic (6.17e-2)" "unprognostic (5.57e-2)" "unprognostic (2.20e-2)" "unprognostic (7.00e-2)" "unprognostic (4.22e-5)" "unprognostic (2.82e-1)" "unprognostic (9.55e-2)" "unprognostic (2.75e-3)" "unprognostic (3.66e-2)" 0.5 1.4 0.0 0.0 0.5 0.0 0.2 1.2 1.9 1.3 0.2 0.1 0.0 0.5 0.0 0.0 0.4 0.0 0.2 0.0 0.5 3.8 0.0 0.0 0.0 14.5 0.6 0.0 0.2 0.0 0.6 0.0 13.4 0.6 0.0 0.2 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 1.7 2.0 0.3 0.3 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 4.6 15.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 1.2 1.9 0.0 0.5 14.5 0.6 13.4 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.7 0.1 0.0 0.0 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 4.1 5.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 ITK "EMT, LYK, PSCTK2" ENSG00000113263 "IL2 inducible T cell kinase" Q08881 5 157142933-157255185 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Adaptive immunity, Immunity" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 14 "lymphoid tissue: 57.9" "Group enriched" "Detected in some" 6 "dendritic cells: 51.7;granulocytes: 31.8;NK-cells: 42.2;Plasma cells: 34.0;T-cells: 115.7" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Group enriched" "Detected in many" 23 "gdT-cell: 39.6;MAIT T-cell: 26.4;memory CD4 T-cell: 55.6;memory CD8 T-cell: 54.9;naive CD4 T-cell: 78.2;naive CD8 T-cell: 65.0;NK-cell: 29.3;T-reg: 73.2" "Group enriched" "Detected in many" 23 "NK-cells: 29.3;T-cells: 78.2" "Group enriched" "Detected in some" 10 "JURKAT: 62.2;MOLT-4: 23.7" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA043670 Uncertain "Plasma membrane,Cytosol" NA NA "Cluster 20: T-cells - T-cell receptor" "Cluster 3: T-cells - Adaptive immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" "Plasma membrane, Cytosol" "HPA043670: " "unprognostic (2.08e-3)" "unprognostic (6.57e-4)" "unprognostic (5.06e-3)" "unprognostic (4.96e-5)" "unprognostic (1.52e-2)" "unprognostic (1.12e-4)" "unprognostic (8.45e-4)" "unprognostic (1.56e-2)" "unprognostic (1.87e-2)" "unprognostic (5.99e-3)" "unprognostic (1.76e-1)" "unprognostic (2.52e-1)" "unprognostic (4.52e-6)" "unprognostic (3.64e-1)" "unprognostic (4.42e-2)" "unprognostic (1.46e-1)" "unprognostic (3.26e-2)" 1.0 0.3 0.0 15.9 0.0 3.7 0.9 0.0 0.0 1.0 0.0 1.4 0.7 0.4 0.0 1.4 0.4 4.2 0.2 0.0 0.0 0.3 1.6 3.1 29.3 0.0 0.0 0.1 0.2 0.0 0.0 0.2 0.0 0.4 1.5 0.0 0.3 0.1 0.0 0.2 4.0 0.5 0.0 10.5 3.1 0.5 0.0 57.9 0.5 0.0 24.6 3.9 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 3.9 0.0 0.0 0.0 0.0 4.5 0.0 0.0 0.0 0.0 0.0 0.0 62.2 0.0 0.0 0.0 0.0 23.7 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.1 0.0 39.6 0.0 26.4 0.0 55.6 54.9 0.1 0.0 78.2 65.0 1.3 29.3 2.3 0.1 73.2 44.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 6.2 0.0 4.0 2.7 0.6 0.0 0.0 0.0 0.4 0.4 0.9 0.0 0.6 1.8 0.0 0.1 51.7 0.1 0.0 0.1 8.5 0.2 0.3 0.8 0.0 1.7 0.2 0.0 0.0 1.1 7.7 0.4 31.8 0.1 1.8 1.0 0.0 0.0 0.2 0.0 0.0 1.6 5.1 6.7 0.0 2.9 1.8 1.0 2.8 0.0 42.2 0.0 0.1 0.0 0.0 0.0 34.0 0.3 0.0 0.4 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.2 3.4 0.1 115.7 0.0 0.1 0.6 JAK1 "JAK1A, JAK1B, JTK3" ENSG00000162434 "Janus kinase 1" P23458 1 64833229-65067754 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "NK-cells: 700.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "ASC diff: 336.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB013088 Approved NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 63: NK-cells & T-cells - Immune response" "CAB013088: " "prognostic favorable (9.63e-4)" "unprognostic (1.24e-1)" "prognostic favorable (2.81e-4)" "unprognostic (5.10e-2)" "unprognostic (1.16e-1)" "unprognostic (4.21e-2)" "unprognostic (1.53e-1)" "unprognostic (7.00e-3)" "unprognostic (8.40e-2)" "unprognostic (7.88e-3)" "unprognostic (1.66e-2)" "unprognostic (8.84e-2)" "prognostic favorable (2.67e-4)" "unprognostic (2.35e-1)" "unprognostic (2.04e-1)" "unprognostic (7.30e-2)" "unprognostic (3.51e-1)" 99.6 38.2 44.8 73.9 42.6 51.4 60.7 46.7 45.4 58.2 61.7 50.5 33.9 56.7 60.8 38.7 40.7 64.2 49.5 46.0 53.9 55.4 86.6 62.1 110.1 56.0 47.0 77.1 46.7 55.0 35.6 57.0 49.1 42.2 54.5 41.7 34.2 55.2 83.4 79.2 50.8 64.2 44.0 88.3 49.5 46.8 59.8 103.8 45.0 118.6 101.7 81.2 39.3 45.5 50.4 66.2 27.7 3.0 336.8 177.2 35.1 76.3 116.1 64.6 75.7 21.4 27.7 76.5 59.1 142.8 118.7 27.8 19.4 63.6 93.8 102.7 29.5 104.0 32.1 56.2 126.6 40.2 68.4 159.9 92.6 97.2 103.0 78.4 208.7 37.0 37.9 78.9 80.1 31.2 22.3 39.6 18.6 65.3 37.4 30.5 77.8 28.5 213.8 84.9 19.8 57.9 107.4 51.6 52.9 56.6 104.3 28.6 180.8 74.7 34.1 174.2 42.0 47.7 23.6 60.4 70.5 57.9 34.1 162.4 52.1 146.8 94.0 66.3 105.7 89.1 90.2 100.7 69.4 73.1 97.0 80.6 177.9 305.4 76.2 55.0 117.1 130.8 44.8 42.6 46.7 45.4 46.0 53.9 56.0 47.0 49.1 44.0 59.8 45.5 211.2 51.3 94.9 62.3 219.8 116.6 150.7 91.3 78.0 37.0 66.2 71.6 112.8 87.2 84.2 112.2 22.9 9.0 345.0 89.2 43.0 171.3 125.2 90.1 167.0 183.0 66.4 52.8 59.6 213.8 105.2 131.9 91.3 151.2 57.0 48.7 174.2 91.4 58.5 21.9 85.3 62.0 69.2 160.2 148.9 101.7 96.0 177.9 49.8 80.6 234.8 53.5 700.3 61.3 42.7 217.5 58.6 84.7 175.2 183.8 53.7 79.0 61.9 38.6 164.3 70.6 191.8 40.8 53.1 71.2 166.1 12.2 256.0 95.7 47.6 200.1 JAK2 JTK10 ENSG00000096968 "Janus kinase 2" O60674 9 4984390-5129948 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Adaptive immunity, Immunity, Innate immunity" "Chromatin regulator, Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 93.4;Inhibitory neurons: 122.3;Microglial cells: 106.8;Oligodendrocyte precursor cells: 69.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 132.5" "Lineage enriched" "Detected in all" 5 "granulocytes: 132.5" "Group enriched" "Detected in many" 5 "ASC diff: 42.2;HDLM-2: 75.0;HEL: 154.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013089, HPA040820, HPA043870" Approved Supported "Nucleoplasm,Plasma membrane,Focal adhesion sites" No No "Cluster 46: Basophils - DNA binding" "Cluster 16: Immune cells - Immune response" "Cluster 36: HEL - Hemostasis" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "Plasma membrane, Focal adhesion sites" "CAB013089: AB_2533647, HPA040820: AB_2677151, HPA043870: AB_2678708" "unprognostic (2.24e-3)" "unprognostic (2.76e-2)" "unprognostic (1.50e-2)" "unprognostic (7.67e-2)" "unprognostic (5.50e-2)" "unprognostic (3.09e-2)" "unprognostic (1.48e-1)" "unprognostic (7.36e-2)" "unprognostic (1.09e-1)" "unprognostic (5.49e-3)" "unprognostic (1.58e-1)" "unprognostic (1.72e-2)" "unprognostic (3.85e-1)" "unprognostic (4.53e-2)" "unprognostic (3.43e-2)" "unprognostic (1.96e-1)" "unprognostic (7.37e-3)" 15.6 7.6 3.2 19.2 3.7 21.7 8.9 6.3 9.1 8.5 1.1 6.7 6.5 11.3 8.6 8.8 8.0 10.5 24.5 2.7 3.1 6.8 4.5 10.9 18.2 3.3 1.8 11.5 3.8 6.5 2.9 11.0 2.0 6.8 6.5 12.8 4.0 6.2 9.8 11.2 7.7 9.5 3.5 17.6 13.4 9.8 1.7 7.5 4.8 8.9 12.7 11.7 9.1 3.9 6.8 3.7 3.7 6.3 42.2 12.4 1.1 9.1 8.6 7.2 4.6 1.2 2.0 0.3 2.1 5.4 5.4 2.3 4.4 5.1 4.9 75.0 1.4 154.7 7.6 1.7 10.0 10.5 7.1 9.5 2.1 2.8 4.5 7.6 6.6 5.1 10.9 17.4 11.6 2.2 2.9 12.8 3.3 3.3 4.3 5.1 8.2 2.2 4.7 3.5 4.2 2.4 2.6 3.5 2.8 3.6 2.0 15.4 13.1 10.2 3.6 10.7 6.4 3.1 6.4 1.5 13.6 4.7 5.3 132.5 20.5 38.2 5.6 20.1 4.5 5.6 4.1 3.1 26.5 4.9 2.2 2.8 19.2 9.6 16.4 9.7 4.5 7.7 3.2 3.7 6.3 9.1 2.7 3.1 3.3 1.8 2.0 3.5 1.7 3.9 14.3 16.0 7.9 31.6 12.9 9.7 3.3 4.9 10.8 8.0 5.2 3.4 30.0 0.0 6.7 7.3 8.4 1.9 13.9 11.7 1.9 3.3 8.6 5.1 11.2 9.4 3.0 19.8 93.4 3.9 0.9 8.9 38.7 5.6 14.0 11.4 4.6 1.9 14.2 8.4 122.3 4.5 0.0 33.6 28.8 7.1 23.6 38.9 5.4 106.8 49.5 12.6 8.2 69.9 42.3 7.0 20.9 33.4 10.7 3.0 3.9 3.3 7.1 11.2 0.0 9.7 12.5 15.0 5.5 11.6 8.4 3.4 10.4 5.1 4.1 4.5 JAK3 "JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK" ENSG00000105639 "Janus kinase 3" P52333 19 17824780-17848071 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Adaptive immunity, Immunity, Innate immunity" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, SCID" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 55.1" "Cell type enhanced" "Detected in many" "B-cells: 27.8;dendritic cells: 20.1;Macrophages: 17.9;NK-cells: 18.6;Plasma cells: 18.4;T-cells: 37.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "HDLM-2: 35.7;HEL: 15.9;HMC-1: 15.5;Karpas-707: 40.2;U-266/70: 15.4;U-266/84: 24.7;U-937: 24.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA070314 Enhanced Approved "Plasma membrane,Cytosol" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 2: Immune cells - Immune response" "Cluster 2: Karpas-707 - Immune response" "Cluster 58: T-cells - T-cell receptor" "Plasma membrane, Cytosol" "HPA070314: AB_2686251" "unprognostic (5.59e-3)" "prognostic favorable (6.42e-5)" "unprognostic (5.71e-2)" "unprognostic (2.34e-1)" "unprognostic (6.13e-3)" "unprognostic (1.11e-3)" "unprognostic (4.21e-2)" "unprognostic (2.60e-1)" "unprognostic (2.38e-2)" "unprognostic (2.36e-1)" "unprognostic (3.58e-2)" "unprognostic (1.94e-1)" "prognostic unfavorable (2.89e-14)" "unprognostic (2.28e-1)" "unprognostic (2.21e-2)" "unprognostic (4.43e-2)" "unprognostic (7.61e-2)" 6.7 2.5 4.0 36.3 4.4 18.6 4.0 3.9 5.6 3.3 3.7 4.0 3.0 2.2 2.4 2.8 5.3 4.8 3.2 4.1 6.7 6.2 2.9 13.1 40.5 7.3 6.1 15.5 1.8 1.9 3.1 5.7 6.4 4.4 3.1 0.6 3.5 1.9 0.7 1.7 15.4 3.5 5.5 55.1 4.6 2.6 6.6 11.3 4.9 0.9 29.7 7.4 3.1 6.1 0.2 0.6 0.5 1.8 0.6 2.4 0.4 0.8 0.0 0.1 0.1 0.0 1.6 0.7 3.3 0.7 0.4 0.2 0.0 0.4 0.0 35.7 0.0 15.9 0.1 1.5 1.2 0.0 15.5 8.4 0.5 0.1 0.0 0.1 0.3 3.6 0.1 40.2 0.0 0.7 6.5 0.0 0.3 0.9 1.3 8.2 0.0 0.7 0.8 0.0 0.0 0.6 0.2 0.4 0.1 0.2 3.5 2.4 0.7 0.0 0.7 0.0 0.0 15.4 24.7 4.3 0.1 24.2 0.3 2.0 7.5 0.3 17.8 14.6 20.2 9.4 21.1 18.6 6.8 10.3 20.2 18.5 25.1 13.4 14.2 5.5 18.0 12.4 4.0 4.4 3.9 5.6 4.1 6.7 7.3 6.1 6.4 5.5 6.6 6.1 5.5 0.0 4.6 2.3 27.8 0.8 0.6 0.5 0.6 0.6 0.5 0.8 1.9 0.0 1.0 1.8 0.0 1.1 20.1 0.0 0.0 0.5 1.0 0.3 2.1 8.0 0.0 6.1 4.3 0.4 0.8 4.6 2.0 0.4 5.1 0.8 9.7 0.4 14.5 0.0 2.6 0.0 0.0 9.2 1.9 2.0 12.5 17.9 3.6 4.7 16.6 0.9 18.6 0.0 0.4 0.5 0.0 14.7 18.4 0.5 0.0 0.3 0.9 0.7 6.6 0.3 2.9 0.3 0.7 0.3 1.0 1.4 37.7 14.8 0.1 0.6 KDR "CD309, FLK1, VEGFR, VEGFR2" ENSG00000128052 "Kinase insert domain receptor" P35968 4 55078481-55125595 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, RAS pathway related proteins" "Angiogenesis, Differentiation, Host-virus interaction" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in many" 9 "Adipocytes: 157.8;Endothelial cells: 143.8;Hepatic stellate cells: 158.1;Muller glia cells: 206.6" "Cancer enhanced" "Detected in all" "renal cancer: 27.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 9 "HUVEC TERT2: 74.8;TIME: 83.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004028, HPA073577" Enhanced Approved "Nuclear membrane,Vesicles" "Intracellular and membrane" NA NA 11000000 "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 5: Muller glia cells - Visual perception" Vesicles "Nuclear membrane" "CAB004028: AB_2212507, HPA073577: " "unprognostic (1.61e-1)" "unprognostic (2.03e-1)" "unprognostic (9.65e-2)" "unprognostic (1.97e-1)" "unprognostic (9.63e-2)" "unprognostic (1.22e-2)" "unprognostic (1.78e-3)" "unprognostic (2.59e-2)" "unprognostic (1.19e-2)" "unprognostic (1.10e-1)" "unprognostic (8.79e-3)" "unprognostic (1.34e-1)" "prognostic unfavorable (7.26e-4)" "unprognostic (4.00e-2)" "unprognostic (2.30e-1)" "unprognostic (3.22e-1)" "unprognostic (1.86e-1)" 41.6 11.7 2.7 4.3 3.8 0.0 26.1 2.8 4.1 14.8 10.4 6.3 2.2 39.5 2.9 4.0 17.9 5.6 20.6 2.1 2.8 15.7 9.2 23.5 2.8 3.2 3.6 5.2 6.2 8.6 11.0 30.9 3.5 11.7 1.0 16.4 5.3 10.0 6.5 5.9 7.5 7.5 3.3 4.4 8.4 1.8 4.5 1.0 34.4 4.6 1.0 8.6 7.5 3.4 0.0 0.0 4.4 0.0 0.4 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.6 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 6.6 0.0 0.0 8.5 0.0 0.0 0.9 0.0 0.0 0.4 0.2 74.8 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.9 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 83.4 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 3.8 2.8 4.1 2.1 2.8 3.2 3.6 3.5 3.3 4.5 3.4 157.8 0.0 4.9 0.0 1.4 2.5 0.5 0.1 1.8 11.7 1.3 2.5 9.4 1.5 18.4 0.0 0.0 0.1 0.8 0.0 0.0 0.5 0.8 0.4 2.6 143.8 0.0 2.7 0.1 0.0 0.1 8.3 0.0 0.8 2.5 0.0 158.1 3.3 0.4 0.0 1.3 0.0 0.0 10.6 2.1 0.9 0.0 1.2 7.2 7.5 0.0 206.6 0.0 0.0 6.1 0.5 0.0 0.4 1.3 0.5 0.0 0.0 3.9 7.9 0.0 0.9 7.5 0.3 0.9 0.8 2.7 0.1 0.6 1.6 0.0 1.4 KIT "C-Kit, CD117, PBT, SCFR" ENSG00000157404 "KIT proto-oncogene, receptor tyrosine kinase" P10721 4 54657918-54740715 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, RAS pathway related proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "breast: 114.9" "Cell type enhanced" "Detected in many" "Breast glandular cells: 83.1;granulocytes: 529.3;Inhibitory neurons: 111.2;Ionocytes: 101.7;Melanocytes: 211.7" "Cancer enhanced" "Detected in many" "testis cancer: 28.6" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 7 "basophil: 20.3;eosinophil: 12.8;NK-cell: 13.1" "Group enriched" "Detected in many" 7 "granulocytes: 20.3;NK-cells: 13.1" "Group enriched" "Detected in many" 13 "HEL: 247.2;HMC-1: 496.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003288, HPA004471, CAB068253, CAB072867, HPA073252" Enhanced Supported Supported "Plasma membrane" NA NA 49000000 "Cluster 2: Granulocytes - Unknown function" "Cluster 5: Breast - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 60: Granulocytes - Receptor signaling" "Plasma membrane" "CAB003288: AB_2335702, CAB068253: AB_2665717, CAB072867: AB_2665718, HPA004471: AB_1078431, HPA073252: AB_2686589" "unprognostic (1.55e-2)" "unprognostic (1.91e-1)" "unprognostic (4.04e-2)" "unprognostic (8.19e-2)" "unprognostic (3.96e-2)" "unprognostic (2.18e-2)" "unprognostic (2.33e-2)" "unprognostic (1.97e-2)" "unprognostic (3.60e-2)" "unprognostic (1.64e-1)" "unprognostic (2.20e-1)" "unprognostic (1.92e-2)" "prognostic favorable (5.63e-4)" "unprognostic (1.34e-3)" "unprognostic (1.87e-1)" "unprognostic (1.29e-2)" "unprognostic (2.30e-1)" 6.6 1.8 8.2 5.3 6.3 6.4 114.9 21.4 6.5 17.6 5.1 13.5 9.2 9.6 5.9 13.0 2.9 20.3 3.4 23.9 5.1 12.4 0.8 21.8 3.4 6.8 12.3 45.0 2.6 1.7 1.9 10.0 8.8 5.6 16.0 3.2 21.4 8.7 1.1 24.5 13.4 10.1 5.9 5.0 17.4 6.2 16.7 3.1 47.1 6.9 6.2 14.5 4.9 5.1 0.0 0.0 3.9 0.0 0.7 0.3 0.0 3.3 4.6 12.6 15.8 0.0 0.0 0.0 0.0 7.3 0.6 0.3 2.6 0.0 10.8 0.0 5.9 247.2 0.0 0.0 0.0 0.0 496.2 0.0 0.0 0.0 0.0 0.0 28.4 4.3 3.5 0.5 0.0 0.0 1.4 2.5 6.9 0.0 0.0 0.8 0.0 0.0 0.0 24.2 6.0 2.1 0.0 0.0 0.0 14.1 0.0 2.6 0.3 0.5 0.0 4.9 0.1 0.4 0.0 0.0 0.5 0.9 0.6 20.3 0.0 12.8 0.1 0.0 2.3 0.0 0.4 0.9 2.3 0.0 0.0 0.0 1.0 13.1 1.4 0.1 0.0 0.2 8.2 6.3 21.4 6.5 23.9 5.1 6.8 12.3 8.8 5.9 16.7 5.1 7.3 6.4 21.9 9.8 1.0 14.3 0.9 0.4 2.2 4.5 83.1 59.2 0.7 4.3 3.6 3.7 0.0 0.1 5.2 0.4 3.9 1.0 0.0 0.2 0.7 9.2 5.4 15.5 0.9 0.0 0.1 2.8 8.6 0.7 529.3 0.5 1.8 0.0 0.3 0.0 111.2 0.5 101.7 0.3 4.2 0.4 1.2 1.6 211.7 14.0 0.2 2.4 0.0 16.1 3.7 0.0 0.1 0.0 3.2 0.5 0.0 0.8 0.1 0.2 0.0 0.7 0.8 0.1 12.3 2.2 3.8 0.3 8.8 63.7 0.6 0.3 LCK ENSG00000182866 "LCK proto-oncogene, Src family tyrosine kinase" P06239 1 32251239-32286165 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 15 "lymphoid tissue: 343.0" "Group enriched" "Detected in many" 9 "dendritic cells: 143.9;NK-cells: 272.9;T-cells: 255.5" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Group enriched" "Detected in all" 12 "gdT-cell: 1109.8;MAIT T-cell: 1034.8;memory CD4 T-cell: 1123.8;memory CD8 T-cell: 1201.7;naive CD4 T-cell: 1260.7;naive CD8 T-cell: 1168.7;NK-cell: 641.5;T-reg: 1682.7" "Group enriched" "Detected in all" 12 "NK-cells: 641.5;T-cells: 1682.7" "Group enriched" "Detected in some" 6 "JURKAT: 365.7;MOLT-4: 536.9;U-698: 302.7" "Low region specificity" "Detected in some" "Low region specificity" "Detected in single" "HPA003494, CAB003816" Enhanced Approved "Golgi apparatus" NA NA "Cluster 20: T-cells - T-cell receptor" "Cluster 63: T-cells - Adaptive immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 63: NK-cells & T-cells - Immune response" "Golgi apparatus" "CAB003816: AB_562158, HPA003494: AB_1852751" "unprognostic (6.38e-3)" "unprognostic (5.45e-3)" "unprognostic (8.39e-2)" "prognostic favorable (2.96e-6)" "unprognostic (2.20e-2)" "prognostic favorable (2.91e-4)" "unprognostic (4.78e-3)" "unprognostic (1.33e-2)" "prognostic favorable (5.65e-5)" "unprognostic (3.07e-2)" "unprognostic (3.80e-2)" "unprognostic (2.83e-1)" "prognostic unfavorable (2.60e-5)" "unprognostic (8.15e-2)" "unprognostic (4.05e-2)" "unprognostic (7.39e-2)" "unprognostic (1.17e-2)" 3.4 2.2 0.4 50.6 0.5 13.7 2.3 0.4 0.5 2.2 0.7 6.9 7.6 1.7 13.0 3.9 2.1 9.4 1.9 0.5 0.4 3.8 3.8 11.4 111.0 0.8 0.5 1.6 0.9 0.5 0.8 1.1 0.6 2.8 6.5 0.0 4.8 1.4 1.3 1.9 23.1 2.3 0.6 39.9 12.1 1.1 0.5 343.0 3.7 1.4 79.6 13.2 2.7 0.6 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.6 0.7 64.1 3.5 0.0 0.3 0.1 0.0 0.2 0.0 0.1 0.6 0.0 0.0 1.4 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 365.7 0.2 0.0 0.0 0.0 536.9 0.2 5.9 4.6 0.3 20.6 0.1 0.3 0.3 0.2 0.1 0.0 0.1 0.3 0.3 0.4 0.6 0.4 0.0 0.0 1.7 0.1 0.1 0.7 0.3 302.7 0.0 0.1 0.0 12.8 5.2 6.0 1109.8 4.9 1034.8 62.0 1123.8 1201.7 5.2 98.9 1260.7 1168.7 33.6 641.5 6.0 7.7 1682.7 1836.9 0.4 0.5 0.4 0.5 0.5 0.4 0.8 0.5 0.6 0.6 0.5 0.6 4.9 0.0 9.3 0.0 23.4 4.6 1.2 0.4 0.0 0.0 3.5 5.2 1.8 4.3 1.6 3.7 0.0 0.3 143.9 0.9 0.0 0.6 0.1 1.0 0.5 3.4 2.4 10.1 0.2 0.5 0.2 3.1 7.7 0.7 5.1 0.0 4.6 1.5 0.3 0.0 0.2 0.3 0.0 7.8 7.3 0.0 0.0 8.1 3.6 0.0 8.7 0.0 272.9 0.5 0.1 4.7 0.0 0.4 15.7 1.0 0.0 1.4 1.8 0.0 0.0 1.5 2.4 4.5 2.0 0.5 3.1 0.4 255.5 2.9 1.3 1.1 LMTK2 "AATYK2, BREK, cprk, KIAA1079, KPI-2, KPI2, LMR2, PPP1R100" ENSG00000164715 "Lemur tyrosine kinase 2" Q8IWU2 7 98106862-98209638 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 50.7;Excitatory neurons: 114.9;Inhibitory neurons: 69.0;Oligodendrocyte precursor cells: 52.3" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "cerebral cortex: 25.2" "Immune cell enhanced" "Detected in single" "neutrophil: 1.4" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA010657, HPA041836" Uncertain Approved "Nuclear speckles,Plasma membrane,Centriolar satellite,Cytosol" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nuclear speckles, Centriolar satellite" "Plasma membrane, Cytosol" "HPA010657: AB_1079259, HPA041836: AB_2677698" "unprognostic (7.36e-2)" "unprognostic (3.16e-1)" "unprognostic (1.59e-1)" "unprognostic (2.60e-3)" "unprognostic (2.47e-2)" "unprognostic (2.45e-1)" "unprognostic (2.35e-2)" "unprognostic (1.23e-1)" "unprognostic (4.96e-1)" "prognostic unfavorable (8.03e-4)" "unprognostic (1.23e-1)" "unprognostic (4.65e-1)" "prognostic favorable (1.12e-7)" "unprognostic (1.88e-1)" "unprognostic (3.92e-1)" "unprognostic (2.16e-2)" "unprognostic (6.38e-3)" 3.5 7.0 4.2 3.9 6.2 13.8 3.6 0.0 25.2 4.9 0.0 9.7 8.8 3.9 3.9 9.5 4.1 4.2 12.4 6.0 0.0 6.6 6.2 6.6 3.6 2.1 0.5 5.0 14.8 10.7 7.0 3.1 1.8 5.1 8.0 8.2 7.9 4.0 11.1 9.0 9.8 3.7 0.0 4.6 6.5 5.2 1.2 4.9 5.8 7.0 4.8 5.8 6.2 8.7 12.5 14.5 11.0 11.4 5.8 4.6 10.2 5.1 5.5 4.9 5.9 11.5 11.1 6.5 14.3 6.5 18.6 13.4 12.8 7.8 7.6 9.4 9.0 4.4 13.0 11.6 7.0 8.0 7.6 3.2 10.5 10.1 13.6 4.9 7.4 7.4 11.8 13.4 4.5 16.9 8.5 4.8 13.4 17.1 7.0 9.2 7.5 13.0 8.2 21.7 7.8 15.7 10.2 18.4 7.4 11.0 5.1 3.2 9.2 10.2 16.6 20.5 11.7 5.9 11.2 12.8 6.8 6.2 12.3 0.5 0.1 0.1 0.2 0.0 0.1 0.1 0.2 0.2 0.1 0.2 0.3 0.4 1.4 0.1 0.3 0.2 0.2 0.1 4.2 6.2 0.0 25.2 6.0 0.0 2.1 0.5 1.8 0.0 1.2 8.7 6.0 28.9 17.0 28.7 7.8 9.7 4.3 6.2 14.8 14.2 5.5 3.9 22.4 15.7 11.8 1.8 14.6 2.8 7.5 50.7 1.9 6.1 1.1 13.2 7.6 5.7 12.0 8.4 114.9 9.1 1.9 5.4 21.4 26.4 2.5 5.3 2.5 8.4 2.2 6.7 69.0 14.7 4.1 1.6 2.3 2.0 1.8 3.2 1.8 16.9 2.8 6.1 7.2 52.3 29.6 10.3 23.8 4.5 12.9 8.8 14.0 3.0 15.8 10.6 0.0 8.6 5.7 6.9 6.3 15.5 10.9 3.0 8.6 2.7 14.7 20.5 LMTK3 "KIAA1883, LMR3, PPP1R101, TYKLM3" ENSG00000142235 "Lemur tyrosine kinase 3" Q96Q04 19 48485271-48513935 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "brain: 44.0" "Cell type enhanced" "Detected in many" "Club cells: 41.4;Excitatory neurons: 37.0;Inhibitory neurons: 38.8;Urothelial cells: 49.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HMC-1: 9.4;SK-BR-3: 16.4;U-266/70: 9.8;U-266/84: 9.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040203, HPA077070" Enhanced Supported Uncertain "Nucleoplasm,Cell Junctions" NA NA "Cluster 20: T-cells - T-cell receptor" "Cluster 10: Brain - Neuronal signaling" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Nucleoplasm "Cell Junctions" "HPA040203: AB_10671690, HPA077070: AB_2732330" "unprognostic (2.41e-1)" "unprognostic (1.48e-1)" "unprognostic (5.37e-2)" "unprognostic (5.45e-2)" "unprognostic (2.95e-1)" "unprognostic (1.71e-2)" "unprognostic (5.67e-2)" "unprognostic (2.46e-1)" "unprognostic (2.09e-1)" "unprognostic (2.51e-3)" "unprognostic (5.71e-2)" "unprognostic (1.47e-1)" "prognostic favorable (3.18e-8)" "unprognostic (1.38e-1)" "unprognostic (3.22e-2)" "unprognostic (3.24e-1)" "unprognostic (6.11e-2)" 0.0 1.7 23.1 0.7 27.5 0.4 0.7 6.1 44.0 0.6 0.0 0.2 3.7 0.1 1.1 0.6 0.3 0.4 0.3 31.7 6.7 1.1 0.0 1.3 1.1 9.9 1.2 0.1 0.8 3.6 5.7 0.6 1.5 1.5 0.0 2.7 2.6 1.1 0.0 0.8 1.9 0.0 0.7 0.6 1.2 0.2 8.4 0.4 0.8 0.0 0.8 0.2 0.0 21.8 6.0 4.4 0.5 0.5 0.0 0.0 5.1 0.1 0.4 0.0 0.2 3.7 5.2 1.6 1.5 0.0 1.4 3.0 0.8 1.9 0.0 0.7 2.8 0.2 2.5 0.9 0.0 0.0 9.4 0.1 1.1 0.3 0.0 2.0 0.0 5.0 1.6 3.6 0.0 7.9 1.1 4.1 1.2 3.4 1.5 4.8 0.0 2.1 1.7 1.2 1.5 2.9 0.2 16.4 0.9 1.2 5.6 0.2 0.1 0.0 1.5 0.1 0.0 9.8 9.3 1.9 0.3 4.6 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.1 0.4 0.0 0.0 0.4 0.4 0.0 0.0 0.0 0.0 0.4 0.0 23.1 27.5 6.1 44.0 31.7 6.7 9.9 1.2 1.5 0.7 8.4 21.8 0.3 3.2 1.7 11.8 2.1 0.5 13.1 17.0 2.8 15.9 20.5 6.2 2.7 2.8 41.4 7.3 0.0 4.9 0.6 0.4 25.4 21.5 0.1 8.4 0.6 0.5 0.0 0.0 37.0 0.4 2.8 0.9 6.6 8.1 0.0 0.6 1.4 0.4 1.3 18.5 38.8 1.2 8.2 0.6 0.9 0.2 0.6 0.4 3.6 1.9 0.2 6.9 0.0 26.2 9.6 17.2 0.1 0.0 14.5 18.8 3.0 0.6 25.9 2.2 0.0 0.4 3.3 4.0 3.3 7.1 1.8 6.8 1.3 2.9 1.5 49.5 LTK TYK1 ENSG00000062524 "Leukocyte receptor tyrosine kinase" P29376 15 41503637-41513887 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Systemic lupus erythematosus" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 13.2;lung: 15.1;salivary gland: 11.8" "Cell type enhanced" "Detected in some" "Distal enterocytes: 25.3;Gastric mucus-secreting cells: 18.8;Hepatic stellate cells: 11.4;Intestinal goblet cells: 7.9;Proximal enterocytes: 15.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 5 "MAIT T-cell: 5.7;plasmacytoid DC: 5.0" "Group enriched" "Detected in many" 10 "dendritic cells: 5.0;T-cells: 5.7" "Cell line enhanced" "Detected in some" "HEL: 5.0;NB-4: 9.7;RH-30: 4.6;THP-1: 14.7" "Low region specificity" "Detected in many" HPA059545 Approved Vesicles NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 43: THP-1 - Innate immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Vesicles "HPA059545: AB_2684057" "unprognostic (9.47e-4)" "unprognostic (5.52e-4)" "unprognostic (1.51e-1)" "unprognostic (2.49e-1)" "unprognostic (4.12e-1)" "unprognostic (5.65e-3)" "unprognostic (1.74e-2)" "unprognostic (7.22e-2)" "unprognostic (2.89e-2)" "unprognostic (2.81e-3)" "unprognostic (9.36e-3)" "unprognostic (5.36e-2)" "unprognostic (4.68e-2)" "unprognostic (5.78e-2)" "unprognostic (1.52e-1)" "unprognostic (1.10e-1)" "unprognostic (1.90e-1)" 0.8 0.6 1.0 1.4 1.6 4.6 0.5 1.2 1.8 0.9 0.6 5.2 12.5 0.2 0.0 0.3 0.4 2.4 1.7 1.3 0.7 4.0 2.9 15.1 1.2 0.6 0.6 0.1 0.3 0.6 0.7 10.4 0.7 0.4 5.7 0.1 11.8 0.3 1.8 1.4 13.2 0.3 0.6 5.5 9.9 2.5 0.8 0.4 0.7 0.0 2.1 0.7 0.7 0.9 0.0 0.0 0.0 0.0 0.1 0.2 0.5 0.1 0.6 0.8 1.2 2.2 0.0 0.0 0.0 0.6 0.0 0.0 2.6 0.0 0.4 0.2 1.3 5.0 0.1 0.0 2.0 0.0 0.0 0.3 0.4 0.0 0.1 0.0 0.0 0.0 1.9 0.0 1.8 0.0 0.0 9.7 0.4 1.8 0.2 0.2 4.6 0.1 0.0 0.0 0.4 2.9 0.1 0.2 0.0 2.6 0.2 14.7 0.0 0.0 0.2 0.1 0.0 0.3 0.2 0.2 0.0 0.5 0.8 0.0 0.0 0.0 0.4 0.0 5.7 0.5 0.3 1.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.1 1.0 1.6 1.2 1.8 1.3 0.7 0.6 0.6 0.7 0.6 0.8 0.9 0.3 0.0 0.0 0.3 1.6 0.1 0.0 0.4 0.0 0.0 0.2 0.1 0.8 2.8 0.9 0.0 0.0 0.3 5.5 25.3 0.0 0.0 2.8 0.1 0.4 1.8 1.8 3.2 2.9 0.2 1.5 0.2 18.8 0.2 0.0 0.3 11.4 0.5 0.1 0.0 0.2 7.9 0.0 1.9 0.6 2.1 0.0 0.4 3.6 0.0 0.4 0.0 1.0 0.5 0.4 0.7 5.5 0.0 2.7 0.0 15.3 0.0 5.6 0.0 0.0 0.3 0.5 2.2 1.2 0.0 0.1 0.4 4.0 0.0 3.8 0.0 LYN JTK8 ENSG00000254087 "LYN proto-oncogene, Src family tyrosine kinase" P07948 8 55879835-56014169 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Adaptive immunity, Host-virus interaction, Immunity, Inflammatory response, Innate immunity" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 73.8;lymphoid tissue: 85.4" "Cell type enhanced" "Detected in many" "B-cells: 237.5;Kupffer cells: 183.7;Macrophages: 226.0;monocytes: 182.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 64.4" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HEL: 198.4;HMC-1: 193.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001231, CAB004492" Enhanced Supported "Golgi apparatus,Vesicles,Plasma membrane" NA NA 770000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 2: Immune cells - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 57: B-cells - Immune response" "Golgi apparatus, Plasma membrane" Vesicles "CAB004492: AB_627897, HPA001231: AB_1079286" "unprognostic (7.87e-2)" "unprognostic (4.89e-2)" "unprognostic (9.04e-2)" "unprognostic (3.74e-1)" "unprognostic (8.12e-2)" "unprognostic (2.17e-1)" "unprognostic (5.70e-2)" "unprognostic (1.11e-1)" "unprognostic (2.79e-1)" "unprognostic (8.80e-2)" "unprognostic (3.68e-2)" "unprognostic (7.15e-2)" "prognostic unfavorable (3.43e-4)" "unprognostic (2.13e-1)" "unprognostic (2.72e-3)" "unprognostic (1.21e-1)" "unprognostic (7.39e-2)" 17.2 7.3 3.9 79.2 4.0 73.8 9.2 7.4 8.7 11.0 7.8 14.2 36.3 6.2 4.8 8.6 10.0 23.5 5.4 4.4 5.5 5.9 14.9 28.2 49.2 9.4 7.2 3.6 9.5 6.3 4.8 23.5 8.3 5.6 13.3 8.9 17.0 9.7 1.6 3.7 31.6 14.2 7.2 85.4 13.3 3.1 9.0 10.4 10.6 4.4 53.1 29.7 5.7 11.2 47.2 24.6 6.9 0.7 0.5 0.0 43.6 34.6 54.7 21.0 15.7 18.0 15.5 41.2 15.0 12.1 15.3 19.3 22.2 23.8 14.6 70.0 19.8 198.4 6.9 5.5 4.0 20.6 193.4 0.8 7.8 0.6 13.6 13.1 27.2 0.0 98.3 90.2 3.0 3.3 0.1 21.5 38.6 72.9 2.1 3.3 9.6 5.0 9.8 24.9 4.5 74.8 17.3 0.1 7.5 44.9 3.4 41.4 33.1 0.0 10.0 0.1 15.0 26.4 13.2 102.4 1.5 38.8 1.7 4.5 12.2 22.7 1.6 28.3 1.3 15.9 0.3 0.6 10.3 16.1 0.2 0.7 64.4 4.3 49.1 16.2 0.0 5.0 3.9 4.0 7.4 8.7 4.4 5.5 9.4 7.2 8.3 7.2 9.0 11.2 21.0 35.3 37.5 27.7 237.5 5.4 23.8 32.4 4.6 6.3 10.3 7.0 2.2 18.6 44.5 9.2 2.1 2.9 130.0 14.5 0.0 21.8 0.9 14.6 26.2 28.1 6.0 40.4 1.1 53.0 65.2 13.6 18.8 15.9 72.8 0.5 22.9 13.2 126.6 0.0 2.5 14.1 14.2 183.7 96.1 2.4 3.4 226.0 5.4 92.8 182.6 54.3 94.7 13.0 1.7 40.7 13.3 1.2 58.9 62.9 26.0 2.1 40.9 2.6 19.7 3.7 6.4 1.2 2.1 4.9 5.8 38.7 25.0 62.5 17.1 82.4 MAP2K1 "MAPKK1, MEK1, PRKMK1" ENSG00000169032 "Mitogen-activated protein kinase kinase 1" Q02750 15 66386837-66491544 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Cardiomyopathy, Disease variant, Ectodermal dysplasia, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hepatocytes: 172.5;Langerhans cells: 265.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003834, HPA026430" Approved Enhanced "Plasma membrane,Cytosol" NA NA 120000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 39: Non-specific - Mitochondria" "Cluster 18: U-2197 - ECM organization" "Cluster 41: Macrophages - Immune response" "Plasma membrane, Cytosol" "CAB003834: AB_562310, HPA026430: AB_1853742" "unprognostic (4.05e-2)" "unprognostic (1.23e-2)" "unprognostic (2.07e-1)" "unprognostic (4.92e-2)" "prognostic unfavorable (1.95e-4)" "unprognostic (1.81e-3)" "unprognostic (5.78e-2)" "unprognostic (9.91e-3)" "unprognostic (1.11e-1)" "unprognostic (1.77e-1)" "unprognostic (1.45e-1)" "unprognostic (7.62e-3)" "unprognostic (1.20e-1)" "unprognostic (2.71e-1)" "unprognostic (1.96e-1)" "unprognostic (1.15e-1)" "unprognostic (9.40e-3)" 57.9 31.0 47.6 38.3 79.7 63.7 32.5 30.2 61.3 31.1 22.5 26.5 19.4 26.3 29.6 51.8 23.7 27.0 40.7 69.4 44.3 31.2 105.3 34.7 49.5 31.6 32.6 25.7 22.4 38.5 26.8 29.6 40.1 26.2 23.6 34.1 29.3 21.8 85.5 23.7 27.0 31.9 35.7 32.6 24.1 15.2 42.8 33.8 22.8 51.3 55.4 31.2 33.7 49.9 105.8 55.3 94.4 39.0 55.3 41.3 53.8 83.6 61.6 76.6 68.1 79.0 82.1 96.8 93.2 59.9 58.2 93.3 88.8 106.4 89.8 79.1 56.8 30.9 50.4 40.7 45.1 41.0 45.3 32.3 64.0 55.9 81.6 81.5 60.7 48.0 54.3 116.7 113.4 40.3 33.5 51.9 47.9 93.9 42.9 39.2 58.1 84.7 74.8 48.5 58.3 31.7 60.8 45.5 63.0 74.9 41.0 33.7 90.8 99.5 63.8 71.1 112.4 74.0 143.1 60.6 105.1 69.9 48.4 3.0 7.5 5.4 6.4 7.7 5.8 2.8 5.6 6.1 7.7 4.6 6.9 4.2 3.5 8.3 7.7 15.1 4.6 2.8 47.6 79.7 30.2 61.3 69.4 44.3 31.6 32.6 40.1 35.7 42.8 49.9 24.5 28.9 24.8 24.2 40.0 82.8 45.9 32.3 21.1 10.0 22.2 10.2 21.5 40.0 24.9 25.8 14.6 48.1 45.0 25.1 46.9 69.4 12.1 16.3 13.9 34.6 21.7 19.0 69.7 23.1 48.8 30.3 17.9 35.4 8.9 19.8 18.9 172.5 51.4 10.1 46.4 15.4 20.3 90.7 265.3 23.6 22.4 115.1 53.4 48.7 87.9 34.9 35.0 28.1 31.7 103.9 23.5 21.8 49.1 87.7 22.2 35.9 17.7 7.8 6.6 16.3 52.4 35.6 42.7 30.3 67.3 51.7 54.0 5.9 19.1 65.4 MAP2K2 "MEK2, PRKMK2" ENSG00000126934 "Mitogen-activated protein kinase kinase 2" P36507 19 4090321-4124122 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Cardiomyopathy, Disease variant, Ectodermal dysplasia, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 724.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003835, HPA051993" Supported Supported Cytosol NA NA 140000 "Cluster 52: Eosinophils - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 25: Spermatids - Spermatogenesis" Cytosol "CAB003835: AB_562312, HPA051993: AB_2681685" "unprognostic (4.39e-1)" "prognostic favorable (3.72e-4)" "unprognostic (4.24e-1)" "unprognostic (1.26e-3)" "unprognostic (2.58e-1)" "prognostic favorable (7.98e-4)" "unprognostic (2.08e-3)" "unprognostic (2.11e-1)" "unprognostic (2.65e-1)" "unprognostic (1.06e-1)" "unprognostic (7.45e-3)" "unprognostic (4.95e-2)" "unprognostic (1.32e-1)" "prognostic favorable (5.43e-5)" "unprognostic (2.91e-2)" "unprognostic (2.25e-1)" "unprognostic (4.90e-2)" 73.9 118.4 145.5 54.1 143.1 102.4 69.1 151.5 190.7 76.6 150.4 103.4 134.0 72.3 23.2 121.6 64.7 30.4 156.6 145.9 147.3 82.6 123.3 66.8 57.1 149.6 152.9 84.1 134.3 54.9 99.3 36.4 154.3 93.9 42.7 68.0 79.6 37.6 289.0 95.8 101.0 31.7 143.5 89.1 92.7 131.6 150.7 69.3 74.6 132.1 41.0 77.2 75.2 142.8 163.1 175.4 93.7 132.8 127.1 151.9 93.8 104.5 138.8 139.6 125.8 153.0 85.5 137.7 95.9 120.0 111.9 114.3 74.2 111.6 107.4 118.1 90.4 50.5 91.4 171.7 194.0 93.6 101.8 168.8 106.8 98.2 129.5 185.5 125.2 123.0 98.1 263.1 119.3 203.5 186.3 130.6 107.8 118.6 125.9 140.7 61.9 159.1 123.5 102.7 126.8 126.3 95.7 130.6 344.1 107.3 101.0 158.5 111.8 113.6 98.2 293.4 163.9 263.1 172.4 100.2 176.5 166.8 199.3 27.5 13.0 45.4 16.9 16.6 13.6 13.0 13.3 17.2 15.9 18.2 12.3 15.9 21.2 18.8 14.1 9.0 14.3 7.3 145.5 143.1 151.5 190.7 145.9 147.3 149.6 152.9 154.3 143.5 150.7 142.8 77.7 9.6 31.9 22.5 62.3 35.4 93.3 21.3 15.4 85.1 92.9 95.4 62.9 44.3 22.8 40.5 41.7 28.7 102.3 300.5 146.8 20.7 248.1 59.5 68.3 52.1 63.2 123.1 17.6 45.5 38.6 60.3 64.7 48.8 19.7 124.4 49.2 48.1 55.0 121.1 23.2 107.7 16.2 56.0 38.2 724.3 35.8 65.6 42.7 10.3 28.5 121.1 62.8 13.0 24.2 47.0 151.8 23.0 79.9 103.2 166.1 92.8 18.9 106.8 26.3 93.1 71.8 23.5 17.4 42.9 63.9 35.6 77.0 120.2 119.9 113.1 MAP2K3 "MAPKK3, MEK3, MKK3, PRKMK3" ENSG00000034152 "Mitogen-activated protein kinase kinase 3" P46734 17 21284672-21315232 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 212.4" "Cell type enhanced" "Detected in many" "Erythroid cells: 325.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB018548 Approved Supported Nucleoplasm,Cytosol NA NA 28000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Cytosol" "CAB018548: AB_631927" "unprognostic (2.31e-1)" "unprognostic (6.39e-2)" "unprognostic (4.63e-2)" "unprognostic (3.68e-1)" "unprognostic (3.54e-3)" "unprognostic (1.60e-1)" "unprognostic (2.97e-2)" "unprognostic (1.35e-2)" "unprognostic (5.25e-3)" "unprognostic (1.88e-2)" "unprognostic (3.16e-2)" "unprognostic (2.18e-2)" "unprognostic (1.33e-1)" "unprognostic (6.48e-2)" "unprognostic (1.22e-2)" "unprognostic (2.92e-1)" "unprognostic (1.77e-1)" 47.3 32.5 12.9 35.3 12.1 212.4 30.7 17.6 23.2 22.7 22.6 33.1 49.0 17.1 14.5 62.7 29.9 40.0 66.7 11.5 14.4 45.7 95.7 67.5 34.0 13.6 14.3 12.6 33.6 17.9 37.1 28.9 14.2 28.9 24.1 6.0 45.3 16.5 132.7 53.1 41.0 22.5 14.3 60.4 42.8 6.2 15.8 20.9 24.0 74.6 41.1 54.1 33.4 17.0 75.5 73.9 9.7 44.5 57.7 36.6 36.3 113.0 121.8 88.3 80.5 82.9 46.6 68.1 44.7 178.3 74.2 72.4 31.0 100.5 62.1 69.5 56.9 39.2 42.0 76.1 18.2 51.9 76.7 28.5 28.2 120.6 35.9 27.7 40.0 38.6 7.7 33.2 74.7 74.1 25.5 49.3 28.1 134.1 42.3 53.0 62.2 50.0 50.5 77.4 26.3 9.4 41.7 45.9 82.0 95.7 22.5 17.7 36.8 83.0 68.4 90.1 73.9 39.8 21.8 88.1 80.2 44.3 44.1 54.1 49.3 77.8 35.9 72.1 31.1 33.3 29.1 33.6 49.6 25.5 17.9 24.1 145.6 15.3 104.7 35.4 44.5 35.6 12.9 12.1 17.6 23.2 11.5 14.4 13.6 14.3 14.2 14.3 15.8 17.0 44.2 38.5 53.6 2.6 51.5 258.0 188.4 57.0 97.9 7.1 69.3 51.3 21.9 44.3 50.5 22.0 4.2 73.3 117.4 109.1 74.3 99.1 1.5 130.5 44.8 49.4 120.4 325.0 7.2 79.8 82.0 43.7 68.3 237.8 94.0 11.5 22.1 73.1 49.0 18.5 8.0 77.0 28.5 59.4 278.7 1.8 12.2 118.1 87.2 4.7 48.3 17.3 35.0 5.5 2.0 129.1 135.3 16.6 85.2 158.7 60.8 44.2 40.4 7.4 0.0 61.9 42.4 1.1 5.3 97.3 218.1 67.0 62.6 10.5 58.5 255.7 MAP2K4 "JNKK1, MEK4, MKK4, PRKMK4, SERK1" ENSG00000065559 "Mitogen-activated protein kinase kinase 4" P45985 17 12020829-12143830 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 226.9;Inhibitory neurons: 189.3;Oligodendrocyte precursor cells: 148.3;Oligodendrocytes: 203.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 10.4" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 5 "SuSa: 177.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007751, HPA060074" Enhanced Approved "Nucleoplasm,Cell Junctions" NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 47: Non-specific - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "Cell Junctions" "CAB007751: , HPA060074: AB_2684197" "unprognostic (1.55e-1)" "unprognostic (1.85e-1)" "unprognostic (4.47e-2)" "unprognostic (1.02e-2)" "unprognostic (1.04e-1)" "unprognostic (2.70e-1)" "unprognostic (2.89e-1)" "unprognostic (2.16e-1)" "unprognostic (1.93e-3)" "unprognostic (2.53e-1)" "unprognostic (2.76e-3)" "unprognostic (4.82e-2)" "unprognostic (5.32e-3)" "unprognostic (3.13e-1)" "unprognostic (2.30e-1)" "unprognostic (7.00e-2)" "unprognostic (1.79e-1)" 11.4 13.1 27.3 10.1 30.2 3.6 14.5 18.7 44.8 12.0 8.7 12.0 10.1 12.1 17.5 18.8 11.4 10.9 15.8 32.7 28.5 16.2 21.8 11.7 11.7 30.0 21.8 12.6 11.5 19.4 13.8 15.8 30.9 14.3 13.1 15.4 10.5 12.7 24.1 15.1 10.5 13.8 19.0 11.6 11.2 11.0 25.9 15.2 16.7 28.2 14.4 14.7 13.0 30.1 31.1 26.2 33.8 17.5 18.3 23.5 21.3 20.6 27.1 23.1 21.9 15.6 10.4 12.8 16.4 32.4 15.2 20.2 29.7 28.8 34.3 22.7 33.7 14.2 14.1 29.8 21.4 13.7 20.5 19.6 27.9 27.0 28.0 23.9 21.3 17.8 15.4 7.3 29.4 11.5 16.8 12.9 19.6 33.2 12.4 20.3 37.8 8.9 31.6 19.7 6.8 19.9 23.8 12.7 20.3 177.7 16.1 10.0 19.6 11.3 17.4 15.8 24.9 14.2 16.9 9.9 21.3 10.7 16.8 0.4 2.1 1.7 2.2 1.2 1.9 2.1 1.8 1.8 1.5 2.7 1.5 2.4 10.4 2.7 3.9 1.5 2.2 1.8 27.3 30.2 18.7 44.8 32.7 28.5 30.0 21.8 30.9 19.0 25.9 30.1 13.9 9.6 19.4 71.8 27.1 41.4 36.1 12.7 66.0 15.3 20.4 16.3 22.6 7.2 18.3 14.7 8.4 12.6 17.7 19.1 25.4 12.3 7.2 16.9 16.4 12.0 12.0 14.5 226.9 14.3 10.3 19.4 42.3 27.3 1.3 20.1 11.0 20.8 11.7 18.5 189.3 13.1 20.3 19.9 14.7 8.9 11.8 15.4 12.4 68.4 24.1 11.3 14.4 148.3 203.0 16.9 9.3 12.8 26.9 37.7 11.0 25.2 8.6 10.0 13.1 19.2 20.2 7.3 9.3 56.7 39.2 25.3 20.7 15.0 13.3 41.5 MAP2K5 "HsT17454, MAPKK5, MEK5, PRKMK5" ENSG00000137764 "Mitogen-activated protein kinase kinase 5" Q13163 15 67542703-67807117 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 8 "Astrocytes: 119.5;Early spermatids: 138.1;Excitatory neurons: 201.4;Inhibitory neurons: 169.3;Late spermatids: 212.4;Microglial cells: 87.1;Oligodendrocyte precursor cells: 146.3;Oligodendrocytes: 146.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022094, HPA027347, HPA027755" Supported Approved Nucleoli,Microtubules NA NA "Cluster 15: NK-cells - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoli, Microtubules" "CAB022094: , HPA027347: AB_10599290, HPA027755: AB_10600883" "unprognostic (4.54e-2)" "unprognostic (1.87e-2)" "unprognostic (4.16e-2)" "unprognostic (9.06e-2)" "unprognostic (1.77e-3)" "unprognostic (1.06e-1)" "unprognostic (1.96e-1)" "unprognostic (3.73e-1)" "unprognostic (2.41e-2)" "unprognostic (2.83e-1)" "unprognostic (1.47e-2)" "unprognostic (5.41e-2)" "prognostic favorable (8.03e-5)" "unprognostic (1.68e-1)" "unprognostic (2.74e-1)" "unprognostic (3.99e-2)" "unprognostic (2.73e-2)" 14.3 14.8 9.2 6.3 9.8 10.3 12.4 11.2 14.1 13.2 4.6 15.7 9.2 11.5 6.1 8.7 12.1 8.8 15.0 11.6 9.9 9.9 10.0 9.7 8.5 9.6 6.5 17.2 13.2 18.8 10.2 11.1 9.4 9.4 8.8 11.2 10.5 10.6 23.2 14.5 10.1 8.9 5.6 9.0 11.6 13.8 7.3 17.2 10.6 17.8 7.6 11.8 11.1 12.3 9.0 23.4 13.8 16.3 20.0 34.9 10.9 8.8 17.8 16.3 17.7 9.4 15.8 14.8 18.2 14.8 17.7 13.3 23.8 14.3 13.4 21.6 23.7 20.2 17.0 10.3 25.1 12.3 12.1 23.9 18.3 11.8 26.6 35.7 21.7 33.6 18.0 24.1 13.6 11.6 20.1 14.7 19.4 10.4 11.3 19.7 16.0 24.9 9.8 16.3 8.6 13.4 9.9 14.5 36.5 23.6 18.2 23.7 18.2 16.7 10.9 11.7 12.1 33.7 43.4 17.5 22.4 27.6 12.3 10.9 5.8 5.6 5.6 4.4 8.3 4.8 5.3 6.7 8.1 4.3 7.3 7.0 1.4 9.4 5.4 3.0 6.2 4.4 9.2 9.8 11.2 14.1 11.6 9.9 9.6 6.5 9.4 5.6 7.3 12.3 7.9 6.4 5.8 119.5 10.0 6.9 8.1 3.7 8.6 12.6 8.6 6.1 8.1 5.7 3.2 5.5 10.4 13.4 10.2 13.2 7.9 9.3 138.1 4.4 5.0 7.6 9.5 9.4 201.4 8.5 10.7 9.7 7.7 3.9 2.5 12.3 12.5 8.7 10.0 5.0 169.3 9.2 4.1 10.1 6.1 212.4 12.5 7.9 10.6 87.1 7.2 17.9 11.3 146.3 146.5 7.5 12.5 11.7 5.6 5.3 12.2 9.7 4.0 8.2 0.0 7.9 6.3 11.9 13.0 9.9 8.2 9.9 10.4 11.6 10.4 4.6 MAP2K6 "MAPKK6, MEK6, MKK6, PRKMK6, SAPKK3" ENSG00000108984 "Mitogen-activated protein kinase kinase 6" P52564 17 69414697-69553865 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 40.5" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 53.9;Glandular and luminal cells: 82.7;Oligodendrocytes: 52.5" "Cancer enhanced" "Detected in many" "endometrial cancer: 8.1" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 7 "classical monocyte: 22.0;neutrophil: 45.9;plasmacytoid DC: 78.3" "Group enriched" "Detected in all" 9 "dendritic cells: 78.3;granulocytes: 45.9;monocytes: 22.0" "Cell line enhanced" "Detected in many" "A549: 40.0;AN3-CA: 21.4;HUVEC TERT2: 28.4;MOLT-4: 21.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007744, HPA031134" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Cytosol" "CAB007744: AB_562318, HPA031134: AB_10603016" "prognostic favorable (2.27e-6)" "unprognostic (2.24e-1)" "unprognostic (8.46e-2)" "unprognostic (4.10e-2)" "unprognostic (3.75e-2)" "unprognostic (1.23e-1)" "unprognostic (7.61e-3)" "unprognostic (9.52e-2)" "unprognostic (3.67e-1)" "unprognostic (4.09e-3)" "prognostic favorable (7.52e-4)" "unprognostic (3.61e-2)" "unprognostic (2.29e-2)" "unprognostic (7.48e-2)" "unprognostic (9.43e-2)" "unprognostic (1.39e-1)" "unprognostic (2.03e-2)" 5.2 1.3 4.2 8.4 4.0 15.9 20.4 11.6 4.0 27.0 7.6 30.7 10.3 6.1 3.2 3.1 4.5 7.2 1.4 2.7 6.2 5.5 12.2 1.8 8.0 5.4 3.8 3.1 8.3 0.3 1.6 1.6 3.9 3.3 31.7 5.8 2.5 3.1 40.5 2.0 10.8 3.3 4.4 4.0 7.4 1.3 5.7 11.5 3.3 21.1 5.9 3.3 1.2 7.7 0.1 40.0 17.6 21.4 7.4 4.0 2.5 0.3 5.8 1.6 2.4 1.2 1.7 1.1 14.2 0.8 1.3 1.9 6.1 0.8 0.5 1.3 3.2 0.1 10.3 11.4 7.4 1.7 1.3 19.0 0.5 0.3 0.0 1.4 28.4 5.3 0.1 2.5 0.0 0.3 21.6 0.7 12.5 0.9 7.3 7.7 1.8 0.5 7.8 5.4 7.8 11.8 1.7 1.3 3.9 9.3 5.4 2.3 5.1 1.9 2.3 1.6 0.5 1.7 2.2 0.5 1.6 2.5 1.5 2.5 22.0 4.0 2.8 2.6 5.0 4.1 3.1 3.5 7.1 5.2 3.6 3.4 45.9 4.7 1.1 78.3 5.0 6.2 4.2 4.0 11.6 4.0 2.7 6.2 5.4 3.8 3.9 4.4 5.7 7.7 11.2 3.2 6.7 27.7 7.7 2.7 4.1 0.8 8.6 5.2 14.3 29.1 1.3 5.7 3.6 0.0 2.1 9.7 29.2 42.3 23.5 1.9 10.2 53.9 11.5 7.9 45.6 5.0 26.0 4.1 6.6 5.0 9.2 82.7 1.3 13.4 4.2 2.5 6.2 3.3 22.4 22.9 0.0 6.8 7.4 2.9 4.4 6.9 3.6 24.4 9.6 31.8 10.3 32.6 52.5 1.1 16.7 3.8 10.7 1.3 14.5 1.5 4.2 4.2 0.0 3.9 5.7 0.1 1.8 4.8 4.3 0.8 13.3 1.4 30.6 2.8 MAP2K7 "Jnkk2, MKK7, PRKMK7" ENSG00000076984 "Mitogen-activated protein kinase kinase 7" O14733 19 7903843-7914478 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001633, CAB004262, HPA064711" Supported Approved "Golgi apparatus,Plasma membrane,Cytosol" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 59: Non-specific - Translation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 52: Non-specific - Transcription" "Plasma membrane, Cytosol" "Golgi apparatus" "CAB004262: AB_627925, HPA001633: AB_1079516, HPA064711: AB_2685331" "unprognostic (1.77e-1)" "unprognostic (5.04e-2)" "unprognostic (1.06e-2)" "unprognostic (2.16e-1)" "unprognostic (4.24e-2)" "prognostic favorable (8.54e-5)" "unprognostic (1.80e-3)" "unprognostic (2.55e-1)" "unprognostic (2.69e-2)" "unprognostic (1.69e-2)" "unprognostic (1.27e-3)" "unprognostic (1.56e-1)" "unprognostic (3.54e-2)" "unprognostic (3.71e-2)" "unprognostic (6.05e-2)" "unprognostic (1.73e-2)" "prognostic favorable (1.56e-4)" 19.1 17.0 17.9 11.7 17.8 19.4 19.5 16.8 19.0 25.1 10.4 24.4 13.1 26.1 3.7 20.2 20.5 5.9 20.8 14.8 15.2 18.7 24.7 17.1 11.7 17.3 17.3 23.2 21.6 9.6 23.4 9.2 17.1 21.0 4.6 5.6 19.2 7.9 52.4 27.9 20.1 6.2 15.1 24.5 18.8 17.5 17.3 10.9 19.0 16.4 6.1 22.0 22.4 19.9 25.8 14.4 12.2 20.2 9.7 9.3 22.8 16.5 8.0 11.0 11.3 20.9 15.2 30.5 25.9 8.8 10.7 22.9 10.7 12.8 4.3 24.7 53.3 21.4 20.9 15.6 12.4 20.1 26.0 10.8 16.1 8.7 9.8 14.5 10.0 21.9 31.9 38.5 6.5 13.4 28.8 48.6 21.7 13.6 32.0 28.5 13.4 31.0 9.8 21.0 22.4 22.5 11.3 19.4 23.9 7.3 21.0 22.7 15.3 33.2 19.0 23.7 22.7 55.5 27.7 28.8 16.6 29.2 13.6 0.0 0.8 0.6 0.6 0.8 0.4 0.7 0.5 0.6 0.4 1.0 0.5 0.7 1.5 1.0 0.5 0.8 0.2 0.4 17.9 17.8 16.8 19.0 14.8 15.2 17.3 17.3 17.1 15.1 17.3 19.9 15.4 25.6 18.1 11.1 27.0 38.6 37.2 22.7 22.2 52.9 23.5 16.5 14.4 24.3 14.5 20.2 77.2 28.3 27.8 31.1 13.7 22.8 4.8 16.2 20.3 19.5 36.5 23.6 9.9 19.0 31.1 18.5 16.3 24.8 10.8 33.3 21.4 22.2 18.6 57.2 11.0 24.0 32.6 22.2 17.1 11.7 28.9 20.5 32.0 6.5 25.3 23.9 46.4 9.0 15.0 25.7 20.8 12.4 30.4 39.8 38.7 18.4 15.3 65.7 32.9 30.2 22.1 17.7 36.4 22.7 42.6 49.3 30.3 30.3 27.6 33.2 MATK "CHK, CTK, DKFZp434N1212, HHYLTK, HYL, HYLTK, Lsk, MGC1708, MGC2101" ENSG00000007264 "Megakaryocyte-associated tyrosine kinase" P42679 19 3777970-3802129 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 20.5;brain: 41.9" "Cell type enhanced" "Detected in many" "dendritic cells: 177.0;Hofbauer cells: 57.4;NK-cells: 422.2;T-cells: 99.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "NK-cell: 76.8" "Group enriched" "Detected in many" 57 "NK-cells: 76.8;T-cells: 46.2" "Cell line enhanced" "Detected in some" "HL-60: 108.3;HMC-1: 30.9;K-562: 48.9;MCF7: 34.4;NB-4: 74.8;SCLC-21H: 30.9;THP-1: 27.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004847, HPA066547" Approved Approved "Microtubules,Cytokinetic bridge,Mitotic spindle,Centriolar satellite,Cytosol" Yes NA "Cluster 48: NK-cells - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 1: K-562 - Erythropoiesis" "Cluster 63: NK-cells & T-cells - Immune response" Microtubules "Cytokinetic bridge, Mitotic spindle, Centriolar satellite, Cytosol" "HPA004847: AB_1079316, HPA066547: " "prognostic favorable (5.27e-4)" "unprognostic (1.28e-2)" "unprognostic (1.84e-1)" "unprognostic (3.54e-2)" "unprognostic (3.36e-1)" "unprognostic (3.39e-2)" "unprognostic (9.50e-2)" "unprognostic (1.23e-1)" "unprognostic (7.91e-2)" "unprognostic (3.19e-3)" "unprognostic (2.07e-2)" "unprognostic (4.51e-2)" "unprognostic (1.16e-2)" "unprognostic (7.59e-2)" "unprognostic (1.66e-1)" "unprognostic (2.26e-1)" "unprognostic (2.33e-2)" 4.7 1.3 18.3 6.6 21.3 20.5 2.5 2.9 41.9 1.1 1.6 2.1 6.6 0.9 0.1 2.1 4.0 4.4 1.4 25.9 8.7 2.4 3.2 9.9 9.4 10.4 11.0 0.7 1.2 0.7 2.7 1.0 8.8 1.3 1.1 2.2 3.2 0.7 0.8 1.9 6.2 0.8 4.7 16.5 4.0 3.1 14.1 3.8 1.6 0.2 4.0 1.6 1.1 23.6 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.5 0.0 0.2 1.7 0.0 1.0 10.6 13.8 0.4 0.0 0.0 18.1 12.0 1.5 2.9 0.0 108.3 30.9 0.1 0.0 0.2 0.1 0.0 0.0 1.2 48.9 0.1 0.0 34.4 0.3 74.8 8.4 9.0 0.3 0.0 0.1 0.0 0.0 0.0 30.9 0.1 0.1 0.1 0.1 0.9 0.0 27.4 3.3 0.0 0.6 1.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 46.2 0.0 31.3 0.0 5.7 29.3 0.8 0.9 2.7 16.4 1.0 76.8 0.2 0.3 0.4 7.6 18.3 21.3 2.9 41.9 25.9 8.7 10.4 11.0 8.8 4.7 14.1 23.6 1.4 0.0 1.1 0.3 11.1 0.4 0.1 0.0 0.0 1.4 4.9 7.2 1.3 0.0 0.0 0.0 12.5 0.3 177.0 0.3 0.0 0.0 2.0 0.2 0.5 1.9 7.1 28.6 17.7 0.0 0.5 0.8 11.7 0.5 44.5 0.1 8.6 1.1 57.4 0.0 8.3 0.3 0.0 6.0 14.6 5.1 0.0 11.5 1.8 4.7 3.0 1.3 422.2 2.0 1.6 0.0 1.1 0.0 17.1 0.1 0.3 0.2 0.7 2.0 0.0 0.5 1.2 0.4 4.5 1.3 1.1 0.3 99.7 0.0 1.1 0.0 MERTK "c-Eyk, mer, RP38, Tyro12" ENSG00000153208 "MER proto-oncogene, tyrosine kinase" Q12866 2 111898607-112029561 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Disease variant, Proto-oncogene, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 162.6;Kupffer cells: 119.8;Macrophages: 46.5;Microglial cells: 124.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 12 "intermediate monocyte: 8.6;non-classical monocyte: 5.5" "Lineage enriched" "Detected in single" 50 "monocytes: 8.6" "Cell line enhanced" "Detected in many" "CACO-2: 35.1;Hep G2: 39.9;HUVEC TERT2: 38.4;RT4: 23.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036196, HPA075622" Enhanced Approved "Endoplasmic reticulum,Plasma membrane,Midbody,Cytosol" Yes NA 65000000 "Cluster 7: Monocytes - Unknown function" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 39: CACO-2 - Unknown function" "Cluster 4: Macrophages - Innate immune response" "Plasma membrane" "Endoplasmic reticulum, Midbody, Cytosol" "HPA036196: AB_10670676, HPA075622: AB_2686759" "unprognostic (2.17e-2)" "unprognostic (8.10e-2)" "unprognostic (4.85e-2)" "unprognostic (2.68e-1)" "unprognostic (2.44e-1)" "unprognostic (1.77e-1)" "unprognostic (1.07e-1)" "prognostic favorable (4.74e-4)" "unprognostic (6.84e-2)" "unprognostic (1.25e-1)" "unprognostic (6.22e-2)" "unprognostic (3.72e-1)" "prognostic favorable (4.43e-5)" "unprognostic (5.13e-2)" "unprognostic (2.11e-1)" "unprognostic (5.86e-2)" "unprognostic (2.05e-2)" 20.1 59.8 22.8 13.5 28.0 1.5 15.3 18.0 29.3 12.6 44.7 10.9 12.3 11.5 26.3 8.4 15.5 12.0 7.0 22.0 22.5 11.4 21.0 13.6 13.1 23.5 22.3 12.6 9.9 21.2 15.5 20.1 22.4 14.1 7.9 16.6 6.4 16.3 3.2 6.4 14.3 14.4 18.4 30.6 13.9 17.2 30.1 6.8 10.1 4.6 8.9 13.6 9.4 22.0 1.0 1.7 7.6 17.3 0.4 0.2 12.3 0.0 0.2 1.0 1.7 35.1 2.2 0.1 8.1 0.1 7.9 0.2 10.2 0.0 1.4 1.5 5.5 7.0 0.0 39.9 0.3 0.2 1.5 0.5 0.0 8.9 0.6 4.0 38.4 1.5 2.2 3.5 2.9 1.8 0.0 9.1 4.8 1.1 6.0 2.9 2.1 3.0 19.4 23.4 0.3 7.2 0.2 0.5 3.2 2.7 0.0 0.4 5.8 1.0 3.4 0.1 0.0 3.1 4.8 0.1 0.0 1.4 0.0 0.0 0.6 0.0 0.0 8.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 5.5 0.1 0.0 0.2 22.8 28.0 18.0 29.3 22.0 22.5 23.5 22.3 22.4 18.4 30.1 22.0 8.8 3.2 27.7 162.6 1.7 1.7 2.9 0.3 1.8 0.6 2.1 4.3 2.7 2.8 6.4 0.0 2.1 3.3 0.4 1.2 1.9 1.1 2.3 8.0 4.7 10.2 0.0 0.4 5.0 1.0 1.1 3.2 0.5 12.1 0.0 3.8 28.5 9.2 25.5 0.0 7.0 2.0 0.0 119.8 1.8 2.7 5.0 46.5 0.0 124.6 1.5 7.7 0.0 10.6 0.6 1.2 1.9 6.8 10.8 2.9 4.4 1.9 1.5 11.3 6.6 1.5 9.2 0.6 1.5 0.6 1.3 18.9 1.3 3.5 1.9 1.6 MET "DFNB97, HGFR, RCCP2" ENSG00000105976 "MET proto-oncogene, receptor tyrosine kinase" P08581 7 116672196-116798377 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Deafness, Disease variant, FDA approved drug targets, Non-syndromic deafness, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 42.9" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 103.6;Club cells: 99.8;Glandular and luminal cells: 161.4;Pancreatic endocrine cells: 93.9;Prostatic glandular cells: 149.3;Urothelial cells: 128.6" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in many" 5 "cerebral cortex: 7.5;hippocampal formation: 6.6;midbrain: 2.5;pons: 4.9;white matter: 7.8" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 203.8;CAPAN-2: 219.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB005282, CAB018577, HPA055607" Approved Approved "Plasma membrane,Cytosol" "Secreted to blood" NA NA 179000000 100000000 "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 44: Endometrium - Transcription" "Plasma membrane, Cytosol" "CAB005282: AB_631940, CAB018577: AB_649068, HPA055607: AB_2682860" "unprognostic (1.60e-2)" "unprognostic (7.71e-2)" "unprognostic (2.53e-2)" "unprognostic (1.58e-1)" "unprognostic (3.57e-3)" "prognostic unfavorable (6.75e-4)" "unprognostic (1.68e-1)" "unprognostic (3.22e-2)" "unprognostic (3.81e-2)" "unprognostic (2.52e-2)" "prognostic unfavorable (1.21e-7)" "unprognostic (1.86e-1)" "unprognostic (1.25e-1)" "unprognostic (5.53e-2)" "unprognostic (8.88e-2)" "unprognostic (2.01e-2)" "unprognostic (2.20e-1)" 10.3 0.8 0.1 3.4 0.6 7.4 8.9 0.1 7.5 13.1 9.6 9.7 6.5 6.4 2.5 6.1 4.7 11.9 6.2 6.6 0.8 20.1 42.9 20.3 2.3 1.1 2.5 0.8 6.6 0.8 3.8 26.4 4.9 6.7 9.3 3.9 8.7 11.2 14.3 7.7 8.2 5.7 0.3 6.0 15.4 0.5 0.5 3.7 17.6 11.0 3.2 18.4 4.4 7.8 203.8 115.3 0.1 0.6 8.6 8.7 7.9 113.7 48.2 60.3 51.1 25.0 219.0 8.4 179.0 72.1 163.3 51.8 19.7 110.0 123.7 0.3 23.4 0.1 112.5 21.4 1.5 0.3 0.2 11.4 42.4 40.6 129.1 109.4 42.4 0.2 4.5 0.8 114.1 5.0 0.1 0.1 17.3 32.9 113.0 0.2 95.3 0.2 105.8 24.0 16.5 0.0 45.4 15.4 44.9 19.8 0.4 0.9 72.3 89.7 30.6 46.7 88.9 2.5 19.1 1.5 99.3 0.3 12.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.1 7.5 6.6 0.8 1.1 2.5 4.9 0.3 0.5 7.8 32.6 28.9 103.6 0.3 1.0 39.0 70.5 58.1 38.1 6.7 6.5 6.9 12.3 11.5 99.8 31.3 0.0 76.0 0.4 20.5 0.0 38.5 0.0 52.5 11.6 20.1 7.2 0.0 2.6 46.9 7.5 7.4 32.6 161.4 0.0 0.0 3.9 30.5 7.0 0.0 1.0 20.5 18.3 1.3 2.2 0.1 0.6 4.4 3.6 1.9 1.0 7.6 0.0 0.5 7.7 93.9 5.5 0.0 0.4 149.3 11.2 15.6 34.5 0.3 0.0 37.8 5.2 0.0 0.6 7.9 17.8 21.8 1.2 0.0 16.4 128.6 MST1R "CD136, CDw136, PTK8, RON, SEA" ENSG00000164078 "Macrophage stimulating 1 receptor" Q04912 3 49887002-49903873 "CD markers, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Immunity, Innate immunity" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skin 1: 62.3;stomach 1: 42.6" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 25.6;Distal enterocytes: 53.9;Gastric mucus-secreting cells: 108.6;Intestinal goblet cells: 25.7;Pancreatic endocrine cells: 31.2;Paneth cells: 30.3;Proximal enterocytes: 27.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 39.3;CAPAN-2: 98.8;HaCaT: 56.3;HBEC3-KT: 59.4;hTCEpi: 83.4;RT4: 67.9" "Not detected" "Not detected" "Not detected" "Not detected" "HPA007657, HPA008180, CAB008972" Enhanced Approved Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "CAB008972: , HPA007657: AB_1079292, HPA008180: AB_1079291" "unprognostic (3.84e-3)" "unprognostic (3.86e-1)" "unprognostic (1.92e-1)" "unprognostic (7.33e-3)" "unprognostic (3.82e-2)" "unprognostic (2.32e-1)" "unprognostic (8.07e-3)" "unprognostic (1.54e-2)" "unprognostic (4.12e-2)" "unprognostic (2.15e-1)" "unprognostic (1.24e-3)" "unprognostic (2.28e-1)" "unprognostic (8.08e-3)" "unprognostic (2.38e-1)" "unprognostic (2.18e-1)" "unprognostic (8.00e-3)" "prognostic favorable (2.33e-5)" 5.1 0.3 1.1 5.1 1.1 0.2 3.8 1.1 1.7 5.7 1.3 26.5 25.2 1.3 1.2 17.5 1.7 11.4 3.2 1.1 0.9 3.4 1.1 9.5 2.5 0.9 0.8 1.0 5.8 0.1 2.7 0.8 0.9 4.7 20.1 0.2 5.4 1.0 1.3 62.3 23.9 2.0 0.8 1.6 42.6 8.4 0.9 8.8 3.4 0.7 5.6 9.2 11.5 1.0 39.3 14.4 0.1 0.6 0.0 0.0 2.2 0.5 0.1 0.0 0.0 4.1 98.8 1.7 8.8 0.5 0.1 56.3 0.0 59.4 0.0 0.9 1.0 0.1 25.9 0.9 0.9 0.0 1.2 0.3 83.4 0.2 11.7 0.2 0.1 0.2 0.8 0.3 0.0 5.1 0.1 0.1 0.3 33.1 34.6 2.9 0.0 1.1 35.8 67.9 1.0 0.1 11.5 22.6 0.2 0.1 17.7 0.9 0.3 0.0 0.3 0.3 0.1 0.5 0.2 0.2 0.3 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.1 1.1 1.1 1.7 1.1 0.9 0.9 0.8 0.9 0.8 0.9 1.0 1.6 25.6 10.3 0.7 1.0 8.8 2.2 14.2 6.8 0.0 2.8 2.5 1.0 0.0 10.6 0.0 0.0 0.1 0.2 53.9 0.0 6.4 15.4 2.9 0.8 0.6 4.2 0.0 1.1 10.0 0.4 0.8 108.6 5.3 0.0 0.1 0.0 0.0 0.1 0.0 1.1 25.7 2.0 0.0 1.4 10.5 0.3 0.5 0.0 1.0 0.6 0.0 1.0 2.0 0.1 31.2 30.3 0.0 0.5 2.2 27.6 0.1 7.6 0.0 0.0 0.5 0.9 1.3 1.5 3.2 4.7 0.0 0.5 0.0 20.1 6.2 MTMR3 "FYVE-DSP1, KIAA0371, ZFYVE10" ENSG00000100330 "Myotubularin related protein 3" Q13615 22 29883169-30030868 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Lipid metabolism" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 81.6" "Cell type enhanced" "Detected in many" "Astrocytes: 111.3;Inhibitory neurons: 78.3;Microglial cells: 90.9;Oligodendrocyte precursor cells: 96.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034515, HPA034516, HPA061399" Uncertain Supported Nucleoplasm,Cytosol NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 64: Astrocytes - Nervous system maintenance" Nucleoplasm Cytosol "HPA034515: AB_10669726, HPA034516: AB_10669727, HPA061399: " "unprognostic (4.39e-3)" "unprognostic (7.84e-2)" "unprognostic (2.46e-2)" "unprognostic (1.76e-2)" "unprognostic (5.61e-2)" "unprognostic (4.51e-3)" "unprognostic (2.25e-2)" "unprognostic (3.20e-2)" "unprognostic (3.42e-1)" "unprognostic (4.39e-1)" "unprognostic (8.33e-4)" "unprognostic (1.28e-1)" "unprognostic (5.35e-4)" "unprognostic (7.96e-2)" "unprognostic (7.64e-2)" "unprognostic (2.49e-1)" "unprognostic (8.38e-2)" 17.8 18.4 18.5 13.0 19.4 81.6 17.0 21.2 18.6 18.9 17.0 15.5 11.1 16.0 12.8 22.4 16.4 12.5 13.9 20.8 19.3 11.7 10.8 20.7 11.5 19.2 19.8 20.4 16.5 18.3 17.0 15.0 17.3 16.0 12.7 21.2 17.2 11.3 36.7 25.5 14.5 14.8 18.6 21.7 15.7 26.2 21.6 16.2 17.2 30.0 13.9 15.1 19.4 16.6 13.4 11.7 17.0 18.3 16.7 12.1 12.8 12.2 17.4 15.7 18.2 10.0 7.9 10.2 7.6 22.1 12.4 16.0 18.5 14.3 16.6 21.0 15.4 18.6 10.6 10.1 15.3 15.9 45.0 12.8 22.9 14.9 26.9 14.7 15.3 10.7 11.6 17.5 10.3 16.2 10.7 11.1 6.5 13.7 7.5 12.5 23.3 10.4 14.1 24.3 19.2 13.1 22.1 19.7 11.7 14.1 11.2 15.3 16.8 25.3 16.7 5.5 8.3 14.7 11.1 9.3 11.0 7.5 11.8 8.3 7.4 11.2 3.2 4.9 4.0 2.3 2.5 3.4 4.1 2.4 3.1 2.7 17.8 4.1 5.4 1.5 2.9 4.3 18.5 19.4 21.2 18.6 20.8 19.3 19.2 19.8 17.3 18.6 21.6 16.6 15.9 3.2 14.8 111.3 13.3 16.7 9.8 11.5 14.8 0.0 13.7 11.0 4.2 10.0 17.7 12.9 0.0 13.6 10.4 21.5 1.9 9.5 14.0 16.8 14.9 10.6 12.5 21.0 61.2 8.8 7.0 12.6 31.6 24.5 7.6 14.7 13.9 10.1 10.9 0.0 78.3 9.2 46.8 20.6 11.7 16.7 13.7 20.8 14.2 90.9 22.3 0.0 12.3 96.5 73.2 12.3 11.1 11.3 13.0 14.6 12.2 7.3 16.4 0.0 6.6 15.3 11.0 26.8 28.0 18.1 13.8 13.7 13.0 8.9 11.5 21.2 MUSK ENSG00000030304 "Muscle associated receptor tyrosine kinase" O15146 9 110668779-110806558 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Differentiation "Developmental protein, Kinase, Muscle protein, Receptor, Transferase, Tyrosine-protein kinase" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 6.2;skeletal muscle: 4.1" "Cell type enhanced" "Detected in some" "Late spermatids: 4.8;Leydig cells: 5.3;Oligodendrocytes: 17.0;Peritubular cells: 19.5;Skeletal myocytes: 23.1" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 16 "LHCN-M2: 24.7;RH-30: 23.7" "Region enhanced" "Detected in some" "basal ganglia: 5.0" "Not detected" "Not detected" NA NA "Cluster 70: Brain - Nervous system development" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 50: Fibroblasts - ECM organization" "unprognostic (6.12e-2)" "unprognostic (9.01e-2)" "unprognostic (5.39e-2)" "unprognostic (3.66e-1)" "unprognostic (3.14e-1)" "unprognostic (1.20e-2)" "unprognostic (1.50e-2)" "unprognostic (2.46e-1)" "unprognostic (3.13e-1)" "unprognostic (7.58e-2)" "unprognostic (6.03e-5)" "unprognostic (4.58e-2)" "unprognostic (1.62e-1)" "unprognostic (9.67e-2)" "unprognostic (5.11e-2)" 0.1 0.2 1.5 1.7 3.0 0.0 0.0 0.8 1.5 0.0 1.6 1.9 1.1 0.0 0.0 1.4 0.0 1.1 1.5 1.2 1.1 0.0 0.3 1.0 0.6 2.7 6.2 0.1 0.1 0.0 0.0 0.3 1.7 0.2 2.5 0.0 0.1 0.0 4.1 0.1 2.4 0.5 2.9 0.0 1.3 1.6 2.0 0.1 0.0 2.0 2.0 1.2 0.0 4.9 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.4 0.0 0.0 1.5 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 24.7 0.0 0.0 0.0 0.5 0.0 0.2 0.0 23.7 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 3.0 0.8 1.5 1.2 1.1 2.7 6.2 1.7 2.9 2.0 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 3.5 0.0 0.3 0.1 0.0 0.0 1.3 0.0 0.0 4.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 4.8 5.3 0.0 0.0 1.9 0.0 0.0 0.0 2.5 17.0 0.0 0.0 19.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 23.1 0.1 0.5 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 NTRK1 "MTC, TRK, TRKA" ENSG00000198400 "Neurotrophic receptor tyrosine kinase 1" P04629 1 156815640-156881850 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Differentiation, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "adrenal gland: 7.0;brain: 21.7" "Group enriched" "Detected in some" 10 "Bipolar cells: 22.8;granulocytes: 55.9;Horizontal cells: 57.2" "Cancer enhanced" "Detected in some" "glioma: 1.3" "Group enriched" "Detected in many" 6 "cerebral cortex: 7.6;medulla oblongata: 19.8;pons: 21.7" "Immune cell enriched" "Detected in single" 116 "basophil: 94.5" "Lineage enriched" "Detected in single" 768 "granulocytes: 94.5" "Cell line enriched" "Detected in some" 4 "HMC-1: 82.1" "Region enhanced" "Detected in many" "basal ganglia: 8.4" "Region enriched" "Detected in single" 6 "basal ganglia: 4.1" "CAB004606, HPA035799, HPA076570" Approved Approved Vesicles,Cytosol NA NA 79000 "Cluster 38: Basophils - Unknown function" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 3: HMC-1 - Innate immune response" "Cluster 62: Horizontal cells - Visual perception" "Vesicles, Cytosol" "CAB004606: AB_628397, HPA035799: AB_2674788, HPA076570: " "unprognostic (5.89e-3)" "unprognostic (7.56e-2)" "unprognostic (2.74e-2)" "unprognostic (5.99e-3)" "unprognostic (7.26e-2)" "unprognostic (1.43e-3)" "unprognostic (1.56e-1)" "unprognostic (7.42e-3)" "unprognostic (7.63e-2)" "unprognostic (1.35e-1)" "unprognostic (6.73e-2)" "unprognostic (2.29e-2)" "unprognostic (3.18e-11)" "unprognostic (2.18e-3)" "unprognostic (3.79e-2)" "unprognostic (1.07e-1)" "unprognostic (4.89e-1)" 0.8 7.0 0.7 0.4 1.8 0.7 0.2 1.8 7.6 0.7 0.7 0.8 0.5 1.0 0.0 0.1 0.5 0.4 1.0 0.3 2.8 3.0 0.0 0.5 0.1 19.8 1.5 0.1 0.2 0.0 0.7 0.2 21.7 1.4 0.0 1.9 0.5 0.3 0.4 0.1 0.3 0.6 0.2 0.1 0.5 1.6 0.4 0.3 0.2 0.2 0.0 0.3 0.5 0.6 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.2 0.1 0.0 0.0 0.0 11.9 0.0 14.0 0.0 0.0 0.0 0.0 82.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 4.4 1.6 0.0 0.2 0.0 2.4 0.2 0.0 1.5 2.5 0.0 0.2 0.0 0.5 1.5 18.2 0.0 0.1 0.0 0.3 0.0 0.1 0.3 0.0 1.1 0.0 0.0 3.5 0.6 0.0 0.0 0.0 0.1 94.5 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.2 0.7 1.8 1.8 7.6 0.3 2.8 19.8 1.5 21.7 0.2 0.4 0.6 0.1 0.0 1.3 0.3 0.0 0.0 0.0 0.0 0.0 22.8 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.6 0.2 0.0 4.2 0.7 0.0 0.0 4.3 0.0 0.1 55.9 0.0 0.0 0.0 0.1 57.2 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 2.8 0.0 0.5 0.0 0.5 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.9 3.2 2.7 0.0 0.1 0.0 1.0 0.1 0.0 0.0 NTRK2 TRKB ENSG00000148053 "Neurotrophic receptor tyrosine kinase 2" Q16620 9 84668551-85027054 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, RAS pathway related proteins" "Differentiation, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, Epilepsy, FDA approved drug targets, Obesity" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 230.0;thyroid gland: 116.9" "Cell type enhanced" "Detected in many" "Astrocytes: 1144.3;Excitatory neurons: 750.1;Inhibitory neurons: 877.7;Oligodendrocyte precursor cells: 557.9" "Group enriched" "Detected in many" 5 "glioma: 31.6;head and neck cancer: 8.0;lung cancer: 9.8;thyroid cancer: 26.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 8.7;HaCaT: 3.0;RPTEC TERT1: 9.7;SH-SY5Y: 11.2;SuSa: 4.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007637, CAB010346, HPA074873" Enhanced Supported "Plasma membrane" NA NA 20000000 "Cluster 73: Brain - Neuropeptide signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane" "CAB010346: AB_2155274, HPA007637: AB_1080385, HPA074873: " "unprognostic (2.75e-3)" "unprognostic (3.48e-2)" "unprognostic (1.82e-2)" "unprognostic (3.26e-1)" "unprognostic (9.26e-2)" "unprognostic (2.56e-2)" "unprognostic (1.29e-2)" "unprognostic (9.16e-2)" "unprognostic (6.13e-2)" "unprognostic (1.05e-1)" "unprognostic (4.25e-2)" "unprognostic (2.18e-2)" "unprognostic (2.66e-2)" "unprognostic (1.20e-2)" "unprognostic (1.21e-2)" "unprognostic (1.31e-1)" "unprognostic (1.39e-3)" 40.5 2.7 201.9 1.7 177.8 0.1 62.2 133.3 190.6 9.8 69.8 5.9 0.4 3.9 3.9 8.2 5.6 33.3 15.2 173.3 230.0 20.4 1.8 10.0 3.1 119.4 218.9 9.7 34.3 2.5 10.1 1.8 151.7 4.7 3.6 41.2 14.4 19.1 2.9 11.6 1.6 3.3 116.6 10.9 1.9 2.4 222.1 4.0 116.9 13.8 4.3 4.9 12.0 117.7 0.0 0.0 8.7 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 1.4 0.0 0.2 0.0 0.0 3.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 9.7 0.7 0.7 11.2 0.0 0.0 0.0 4.9 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.1 0.0 0.3 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 201.9 177.8 133.3 190.6 173.3 230.0 119.4 218.9 151.7 116.6 222.1 117.7 17.4 0.0 0.5 1144.3 0.7 56.6 1.0 1.8 93.9 30.3 144.1 116.8 11.4 0.0 0.2 9.2 6.2 0.0 1.0 8.7 27.4 36.1 1.8 1.2 0.4 8.0 0.0 0.0 750.1 0.7 0.1 76.6 0.0 2.3 0.0 0.1 5.0 0.0 0.2 242.3 877.7 0.7 0.0 0.0 14.2 3.6 104.1 1.4 17.8 65.6 0.6 241.0 0.0 557.9 109.5 0.5 7.0 48.2 0.3 0.9 0.0 7.1 1.7 12.2 124.9 9.9 114.4 0.8 2.3 5.2 24.6 0.0 3.3 0.2 7.2 0.9 NTRK3 TRKC ENSG00000140538 "Neurotrophic receptor tyrosine kinase 3" Q16288 15 87859751-88256768 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Differentiation, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 38.8" "Cell type enhanced" "Detected in many" "Astrocytes: 239.3;Early spermatids: 119.6;Excitatory neurons: 360.0;Inhibitory neurons: 277.8;Late spermatids: 148.9;Microglial cells: 177.1;Oligodendrocyte precursor cells: 499.6" "Group enriched" "Detected in some" 4 "glioma: 2.5;testis cancer: 1.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 8 "U-138 MG: 100.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009233, HPA027484, HPA048065" Approved Supported "Nuclear membrane,Nucleoli,Nucleoli rim" NA NA 19000000 "Cluster 10: Brain - Neuronal signaling" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoli, Nucleoli rim" "Nuclear membrane" "CAB009233: AB_632555, HPA027484: AB_2672297, HPA048065: AB_2680245" "unprognostic (1.27e-3)" "unprognostic (1.24e-2)" "unprognostic (1.98e-2)" "unprognostic (2.04e-2)" "unprognostic (1.65e-1)" "unprognostic (3.34e-1)" "unprognostic (3.18e-2)" "unprognostic (2.23e-2)" "unprognostic (2.34e-1)" "unprognostic (3.91e-1)" "unprognostic (2.88e-1)" "unprognostic (1.09e-1)" "unprognostic (5.78e-3)" "unprognostic (6.45e-3)" "unprognostic (1.06e-2)" "unprognostic (1.26e-2)" "unprognostic (2.49e-3)" 12.8 3.7 31.3 0.8 33.2 0.1 7.8 30.7 34.3 12.8 0.0 3.4 0.5 10.4 3.2 1.3 15.0 1.6 5.8 38.8 25.8 5.1 1.0 5.3 1.2 21.5 19.6 7.2 1.0 0.1 12.2 1.0 22.1 9.0 2.0 5.2 6.8 4.3 1.8 4.8 2.2 3.7 10.9 2.5 3.2 9.8 33.4 1.2 3.0 1.9 2.0 8.7 7.4 21.5 0.0 13.1 2.7 0.3 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.2 0.0 0.0 0.3 0.0 0.0 0.0 0.0 1.0 0.0 0.2 0.3 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.3 0.0 0.0 0.0 0.2 0.1 0.0 0.1 0.0 2.5 0.0 0.0 0.0 2.6 0.1 0.1 0.1 0.7 0.1 0.0 0.0 0.0 0.9 0.1 0.1 0.0 100.6 1.8 0.0 1.3 0.0 0.0 0.0 3.0 0.1 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 31.3 33.2 30.7 34.3 38.8 25.8 21.5 19.6 22.1 10.9 33.4 21.5 0.5 0.0 0.0 239.3 0.0 0.5 6.4 0.0 0.0 53.8 3.7 6.0 5.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 119.6 0.4 25.0 1.2 0.0 0.0 360.0 0.0 0.0 5.7 0.0 0.5 0.0 0.0 2.2 0.0 1.0 1.7 277.8 0.0 0.0 0.0 0.6 148.9 3.4 0.6 0.0 177.1 0.0 8.6 0.0 499.6 7.4 0.0 0.0 27.4 0.0 1.3 0.0 0.1 0.0 3.7 52.6 20.3 40.9 11.0 3.7 0.0 0.1 0.1 0.2 0.0 0.0 0.7 PADI1 "HPAD10, PAD1, PDI, PDI1" ENSG00000142623 "Peptidyl arginine deiminase 1" Q9ULC6 1 17205128-17246007 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "esophagus: 109.5" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 14.8;Extravillous trophoblasts: 14.0;Squamous epithelial cells: 5.6;Urothelial cells: 22.5" "Cancer enhanced" "Detected in many" "pancreatic cancer: 13.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CAPAN-2: 4.2;EFO-21: 2.1;HaCaT: 1.5;RPTEC TERT1: 1.6" "Not detected" "Not detected" "Not detected" "Not detected" HPA062294 Enhanced Approved Nucleoplasm,Cytosol NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 22: Epithelial cell types - Mixed function" Cytosol Nucleoplasm "HPA062294: AB_2684741" "unprognostic (9.30e-2)" "unprognostic (2.44e-1)" "unprognostic (6.15e-2)" "unprognostic (1.40e-1)" "unprognostic (5.22e-2)" "unprognostic (7.27e-2)" "unprognostic (3.84e-1)" "unprognostic (3.37e-2)" "unprognostic (1.41e-1)" "unprognostic (7.75e-2)" "unprognostic (1.01e-3)" "unprognostic (3.64e-2)" "prognostic unfavorable (8.34e-11)" "unprognostic (2.00e-1)" "unprognostic (3.12e-1)" "unprognostic (1.07e-1)" "unprognostic (1.15e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.2 0.0 0.0 0.0 0.1 0.0 109.5 0.0 0.0 0.0 0.0 0.1 0.1 1.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 1.0 0.1 0.2 0.0 0.0 11.5 0.0 0.0 4.1 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 4.4 1.4 18.0 0.0 0.1 0.6 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 4.2 0.0 2.1 0.1 0.1 1.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.6 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.7 0.6 0.9 0.0 0.0 14.8 0.0 3.9 0.0 0.0 0.2 0.0 0.6 0.0 0.6 0.0 0.1 0.1 0.5 0.0 0.0 0.0 0.0 14.0 0.3 0.0 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.4 2.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.8 0.5 0.0 0.0 0.8 0.0 0.0 0.6 0.3 0.0 0.0 0.3 0.2 0.1 5.6 0.0 0.7 0.0 0.1 0.6 22.5 PADI2 "KIAA0994, PDI2" ENSG00000117115 "Peptidyl arginine deiminase 2" Q9Y2J8 1 17066761-17119451 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 240.6;skeletal muscle: 311.8;tongue: 492.3" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 95.9;Distal enterocytes: 178.7;Intestinal goblet cells: 77.3;Oligodendrocytes: 117.1;Paneth cells: 72.3" "Cancer enhanced" "Detected in many" "glioma: 24.7" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "eosinophil: 43.3;neutrophil: 100.6" "Lineage enriched" "Detected in many" 6 "granulocytes: 100.6" "Cell line enhanced" "Detected in some" "A549: 11.6;RPTEC TERT1: 33.1;SK-BR-3: 50.7;T-47d: 13.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA047735 Enhanced NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA047735: AB_2680139" "unprognostic (2.61e-2)" "unprognostic (3.60e-2)" "unprognostic (8.94e-3)" "unprognostic (1.57e-1)" "unprognostic (2.33e-2)" "unprognostic (2.44e-1)" "unprognostic (1.49e-1)" "unprognostic (3.74e-3)" "unprognostic (2.78e-3)" "unprognostic (3.28e-3)" "unprognostic (1.29e-1)" "unprognostic (3.07e-1)" "unprognostic (2.87e-1)" "unprognostic (3.64e-2)" "unprognostic (3.15e-1)" "unprognostic (2.27e-1)" "unprognostic (5.91e-3)" 2.1 0.9 85.9 9.3 161.5 23.7 41.1 164.3 103.9 3.3 33.5 89.8 1.4 0.8 0.6 6.1 2.7 1.6 0.6 82.2 165.1 12.7 0.7 4.4 1.0 205.8 167.0 0.2 1.5 2.1 3.7 1.4 212.0 2.6 92.3 50.5 44.4 1.6 311.8 9.6 8.4 5.8 189.3 13.4 2.2 0.8 144.3 2.1 0.6 492.3 1.3 2.5 1.0 240.6 0.0 11.6 0.1 0.0 0.0 0.0 0.7 0.3 0.0 0.1 0.1 0.1 4.9 0.2 1.5 0.5 0.1 1.6 0.4 0.1 0.3 0.0 0.8 0.5 0.0 0.0 0.0 0.7 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.9 3.8 0.6 1.4 1.6 3.9 0.0 0.0 0.0 0.4 33.1 0.0 2.1 0.2 0.0 50.7 0.0 2.7 13.9 2.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 1.9 0.0 1.3 16.2 43.3 0.0 0.9 0.0 0.0 0.0 0.0 11.7 0.0 0.0 0.0 100.6 0.0 0.2 0.4 0.0 6.4 85.9 161.5 164.3 103.9 82.2 165.1 205.8 167.0 212.0 189.3 144.3 240.6 0.2 0.0 1.3 28.4 1.0 0.3 0.4 0.6 0.0 2.2 31.2 32.5 0.4 0.0 3.3 1.8 95.9 0.2 0.7 178.7 11.7 0.6 6.1 0.0 0.0 8.2 3.6 0.0 1.5 0.0 0.5 0.6 0.0 0.1 17.1 0.5 0.7 0.0 7.2 0.0 1.4 77.3 2.0 4.8 25.8 10.3 0.3 9.2 28.4 15.9 33.8 33.6 0.0 13.6 117.1 0.0 72.3 0.7 0.4 0.5 15.0 0.3 0.2 29.6 0.0 5.6 1.3 0.2 0.4 0.0 0.4 0.1 0.4 0.0 51.8 0.2 PADI3 PDI3 ENSG00000142619 "Peptidyl arginine deiminase 3" Q9ULW8 1 17249098-17284233 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Hydrolase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "esophagus: 17.0;urinary bladder: 25.6" "Cell type enhanced" "Detected in some" "Collecting duct cells: 1.8;Ionocytes: 6.1;Squamous epithelial cells: 1.1;Urothelial cells: 7.9" "Cancer enriched" "Detected in many" 4 "urothelial cancer: 48.6" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "EFO-21: 14.0;RT4: 17.4;T-47d: 12.8" "Not detected" "Not detected" "Not detected" "Not detected" HPA043739 Uncertain Approved Nucleoplasm,Vesicles NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 15: RT4 - Unknown function" "Cluster 22: Epithelial cell types - Mixed function" Vesicles Nucleoplasm "HPA043739: AB_10959466" "unprognostic (4.47e-2)" "unprognostic (9.32e-2)" "unprognostic (1.50e-1)" "prognostic unfavorable (3.22e-4)" "unprognostic (1.05e-3)" "unprognostic (6.66e-2)" "unprognostic (3.10e-3)" "unprognostic (5.88e-2)" "unprognostic (2.06e-4)" "unprognostic (1.03e-1)" "unprognostic (3.47e-4)" "unprognostic (1.76e-1)" "prognostic unfavorable (1.55e-11)" "unprognostic (2.40e-2)" "unprognostic (4.73e-3)" "unprognostic (2.64e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.5 17.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.0 0.0 0.9 3.4 0.0 3.7 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4 25.6 3.6 0.0 0.0 3.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 14.0 0.0 1.4 0.3 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 1.7 0.0 0.0 0.0 0.0 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.0 0.0 17.4 0.0 0.0 0.0 2.5 0.1 0.1 12.8 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 3.8 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.3 0.0 0.0 0.0 0.0 0.3 0.0 0.2 1.8 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 6.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 1.1 0.0 0.0 0.0 0.2 0.0 7.9 PADI4 "PAD, PADI5, PDI4, PDI5" ENSG00000159339 "Peptidyl arginine deiminase 4" Q9UM07 1 17308195-17364004 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Immunity, Innate immunity, Transcription, Transcription regulation" "Chromatin regulator, Hydrolase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 9 "bone marrow: 105.1;lymphoid tissue: 29.9" "Cell type enhanced" "Detected in some" "dendritic cells: 8.3;granulocytes: 12.6;Macrophages: 14.6;monocytes: 22.3;NK-cells: 20.6" "Not detected" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 8 "basophil: 79.9;classical monocyte: 71.3;eosinophil: 97.5;neutrophil: 183.0" "Group enriched" "Detected in all" 9 "granulocytes: 183.0;monocytes: 71.3" "Cell line enhanced" "Detected in some" "HEL: 1.2;RPMI-8226: 1.4" "Not detected" "Not detected" "Not detected" "Not detected" "HPA017007, HPA042825" Enhanced NA NA 29000 "Cluster 5: Granulocytes - Unknown function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 25: RPMI-8226 - Immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "HPA017007: AB_1854921, HPA042825: AB_2678189" "unprognostic (1.70e-1)" "unprognostic (2.25e-1)" "unprognostic (2.23e-1)" "unprognostic (2.98e-1)" "unprognostic (1.27e-1)" "unprognostic (1.13e-2)" "unprognostic (1.47e-1)" "unprognostic (4.91e-2)" "unprognostic (8.49e-2)" "unprognostic (5.22e-2)" "unprognostic (8.55e-2)" "unprognostic (1.81e-1)" "unprognostic (1.66e-3)" "unprognostic (1.50e-1)" "unprognostic (1.28e-1)" "unprognostic (1.56e-2)" "unprognostic (1.80e-1)" 1.8 0.1 0.2 0.7 0.4 105.1 0.3 0.2 0.8 0.1 0.2 0.1 0.1 0.1 0.0 0.4 1.0 0.4 1.1 0.3 0.2 0.5 1.7 7.9 0.3 0.3 0.1 0.1 0.3 0.0 0.2 0.5 0.3 0.2 0.0 0.0 0.2 0.0 0.2 0.2 0.2 0.4 0.0 29.9 0.4 0.1 0.1 1.6 0.3 0.3 0.2 0.7 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 79.9 71.3 97.5 0.4 5.7 0.2 1.1 0.5 0.7 13.9 1.8 2.6 4.5 183.0 4.5 1.8 6.2 0.4 35.8 0.2 0.4 0.2 0.8 0.3 0.2 0.3 0.1 0.3 0.0 0.1 0.4 0.0 0.0 3.7 0.0 2.9 0.0 0.1 0.0 0.0 0.0 0.3 0.1 0.4 0.0 0.0 0.0 0.0 0.0 8.3 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 1.3 0.6 0.0 0.6 0.6 0.0 0.0 12.6 0.1 0.0 0.4 0.2 0.0 0.4 0.0 0.0 3.3 0.4 0.2 0.0 14.6 0.0 0.0 22.3 0.0 20.6 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.6 4.0 0.0 0.0 0.1 2.3 0.1 0.0 0.0 PADI6 ENSG00000276747 "Peptidyl arginine deiminase 6" Q6TGC4 1 17372196-17401699 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Hydrolase "Disease variant" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "NK-cells: 1.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enhanced" "Detected in single" "white matter: 2.4" "Not detected" "Not detected" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 63: NK-cells & T-cells - Immune response" "unprognostic (1.19e-1)" "unprognostic (4.36e-2)" "unprognostic (3.02e-2)" "unprognostic (6.56e-2)" "unprognostic (1.23e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.5 0.0 0.0 0.0 0.0 0.3 0.9 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.4 0.0 0.0 0.7 0.0 1.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 PBK "CT84, FLJ14385, Nori-3, SPK, TOPK" ENSG00000168078 "PDZ binding kinase" Q96KB5 8 27809624-27838082 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "lymphoid tissue: 22.8;testis: 70.3" "Group enriched" "Detected in many" 5 "Early spermatids: 364.9;Spermatocytes: 436.4" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 282.8" "Group enriched" "Detected in many" 4 "basal ganglia: 4.7;white matter: 13.9" "Not detected" "Not detected" "HPA005753, HPA050656" Enhanced Supported Approved Cytosol NA Yes "Cluster 48: NK-cells - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" Cytosol "HPA005753: AB_1855018, HPA050656: AB_2681205" "unprognostic (7.17e-2)" "unprognostic (7.21e-3)" "unprognostic (1.04e-3)" "unprognostic (2.77e-2)" "unprognostic (1.50e-1)" "unprognostic (1.27e-1)" "prognostic unfavorable (8.29e-5)" "unprognostic (3.65e-3)" "unprognostic (7.38e-2)" "unprognostic (2.88e-3)" "prognostic unfavorable (6.56e-4)" "unprognostic (1.20e-1)" "prognostic unfavorable (1.18e-12)" "unprognostic (9.61e-2)" "unprognostic (1.86e-1)" "unprognostic (8.30e-2)" "unprognostic (8.68e-2)" 1.1 0.6 0.1 6.6 0.1 9.1 2.3 0.0 0.1 1.1 0.0 8.9 8.4 1.2 0.0 6.6 0.6 0.7 0.2 0.1 0.1 0.4 1.1 0.7 12.8 0.1 0.3 0.2 0.4 0.2 0.0 5.1 0.2 0.4 10.1 0.0 0.9 0.0 0.2 4.8 8.1 2.7 0.1 1.5 3.6 70.3 0.3 22.8 0.5 0.1 12.4 1.6 2.1 0.1 282.8 94.2 94.4 57.9 8.3 15.7 36.9 129.5 63.0 133.2 112.3 33.7 51.2 156.4 43.3 51.7 150.2 76.4 87.6 44.7 145.7 35.8 48.0 35.0 64.6 49.2 0.6 25.7 54.1 4.4 36.0 62.6 32.8 24.3 68.5 75.9 54.3 100.6 160.4 34.5 87.7 29.1 15.6 80.1 80.0 54.4 126.9 41.2 51.2 44.9 36.1 53.2 48.2 56.0 75.0 26.2 58.0 37.3 40.6 85.6 207.3 111.5 141.5 15.4 39.4 70.1 54.0 43.4 188.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.3 0.0 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.3 0.2 0.1 0.3 0.1 0.2 0.0 0.0 0.0 4.2 8.9 2.8 10.8 0.0 0.0 2.9 2.4 0.5 2.8 2.6 0.0 0.0 29.8 1.3 5.5 0.0 0.6 364.9 2.5 2.2 2.4 0.0 61.7 0.1 0.0 49.3 6.7 6.6 3.5 0.0 13.5 5.7 1.7 5.0 0.0 0.1 9.4 6.1 1.9 1.6 76.8 8.4 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.3 3.0 14.0 2.0 1.5 0.3 0.1 0.0 6.6 0.1 5.8 436.4 38.1 9.4 2.4 6.7 1.9 2.4 18.7 3.8 PDGFRA "CD140a, GAS9, PDGFR2" ENSG00000134853 "Platelet derived growth factor receptor alpha" P16234 4 54229280-54298245 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Chemotaxis, Host-virus interaction" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "ovary: 190.2" "Group enriched" "Detected in many" 8 "Endometrial stromal cells: 423.9;Fibroblasts: 256.4;Leydig cells: 449.8;Oligodendrocyte precursor cells: 499.6;Peritubular cells: 408.9" "Cancer enhanced" "Detected in all" "glioma: 30.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 468.1;ASC TERT1: 216.1;BJ hTERT+: 279.4;fHDF/TERT166: 195.9;HHSteC: 156.3;HSkMC: 392.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004947, CAB018143" Supported Approved "Nucleoplasm,Plasma membrane,Cell Junctions" "Intracellular and membrane" NA NA 300000 "Cluster 34: Basophils - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 36: Stromal cells - Cell proliferation" "Nucleoplasm, Plasma membrane, Cell Junctions" "CAB018143: AB_2162351, HPA004947: AB_2732399" "unprognostic (1.67e-1)" "unprognostic (9.35e-2)" "unprognostic (4.59e-3)" "unprognostic (1.60e-1)" "unprognostic (8.92e-2)" "prognostic favorable (9.33e-4)" "unprognostic (1.24e-1)" "unprognostic (2.00e-2)" "unprognostic (1.46e-1)" "unprognostic (2.18e-2)" "unprognostic (2.18e-1)" "unprognostic (7.01e-2)" "prognostic unfavorable (9.79e-6)" "unprognostic (9.58e-3)" "unprognostic (9.87e-2)" "unprognostic (2.16e-2)" "unprognostic (1.72e-3)" 46.0 28.9 13.9 40.4 13.7 1.6 40.1 8.1 12.8 50.8 18.1 37.7 22.4 44.3 21.8 22.5 50.9 38.5 32.1 11.9 11.0 26.5 16.0 37.9 8.5 16.7 11.9 190.2 13.4 3.0 3.7 62.7 15.1 15.0 35.2 5.3 16.6 18.9 9.6 14.8 31.3 48.1 12.1 46.2 29.4 13.6 8.9 7.6 16.5 41.9 7.2 63.9 38.0 20.0 0.1 0.0 1.0 0.8 468.1 216.1 0.5 25.4 279.4 0.1 0.7 67.6 0.5 0.5 0.5 195.9 0.8 0.6 19.6 0.2 0.1 2.6 1.0 0.7 0.7 1.2 156.3 0.3 0.4 392.0 0.0 31.4 0.0 5.4 0.0 0.7 0.6 0.9 1.1 0.1 0.4 1.2 3.5 0.3 1.1 0.5 0.1 0.1 0.0 0.4 0.6 37.9 0.0 0.5 0.2 2.0 0.7 0.1 0.8 84.9 3.2 93.9 0.2 0.4 0.1 0.8 2.6 0.1 2.2 0.7 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 13.9 13.7 8.1 12.8 11.9 11.0 16.7 11.9 15.1 12.1 8.9 20.0 11.1 0.0 0.5 0.3 0.6 17.1 0.6 2.4 1.2 5.5 4.3 3.2 4.8 0.0 0.8 0.0 0.0 1.4 0.9 0.1 1.9 4.2 2.2 11.7 423.9 5.7 0.0 0.0 1.1 6.7 2.0 256.4 5.1 9.0 0.0 2.6 26.0 1.0 3.1 0.0 19.5 0.2 10.2 0.6 27.3 17.2 449.8 5.4 23.2 39.4 4.7 17.5 0.0 499.6 0.4 20.0 0.0 408.9 0.2 0.9 0.0 0.1 0.5 0.6 0.0 25.7 13.9 1.0 3.4 8.1 15.8 1.4 2.5 49.6 0.0 1.0 PDGFRB "CD140b, JTK12, PDGFR, PDGFR1" ENSG00000113721 "Platelet derived growth factor receptor beta" P09619 5 150113839-150155872 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" Chemotaxis "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in many" 4 "Sertoli cells: 1288.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "non-classical monocyte: 1.6" "Low lineage specificity" "Detected in single" "Group enriched" "Detected in many" 4 "ASC diff: 1350.1;ASC TERT1: 462.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003842, CAB018144, HPA028499" Enhanced Supported "Golgi apparatus,Vesicles" NA NA 39000000 "Cluster 14: Monocytes - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 48: Smooth muscle cells - ECM organization" Vesicles "Golgi apparatus" "CAB003842: AB_562328, CAB018144: AB_2162497, HPA028499: AB_10602018" "unprognostic (4.75e-2)" "unprognostic (2.48e-1)" "unprognostic (5.21e-2)" "unprognostic (3.60e-2)" "unprognostic (3.27e-1)" "unprognostic (5.61e-2)" "unprognostic (1.02e-1)" "unprognostic (3.36e-2)" "unprognostic (2.12e-2)" "unprognostic (2.57e-3)" "unprognostic (6.72e-2)" "unprognostic (1.25e-1)" "prognostic unfavorable (5.87e-8)" "unprognostic (3.13e-3)" "unprognostic (1.25e-2)" "unprognostic (5.47e-2)" "prognostic unfavorable (8.11e-4)" 171.2 25.1 25.4 27.5 27.2 0.7 106.3 20.5 33.3 155.9 43.5 41.6 11.9 101.1 24.2 24.1 89.6 124.5 75.7 22.1 23.2 49.7 13.4 98.3 27.5 22.1 24.6 105.5 20.8 21.9 23.0 113.3 22.8 56.2 14.1 6.3 34.5 43.3 38.1 65.0 37.9 68.9 19.4 41.4 27.9 18.4 27.7 8.7 66.5 44.1 13.8 58.3 98.6 21.6 0.1 0.3 8.3 0.4 1350.1 462.7 3.0 48.9 202.3 33.5 56.4 5.4 0.0 0.0 6.4 142.0 19.0 0.1 0.1 0.4 15.8 0.0 0.0 0.1 3.3 3.5 190.7 0.0 0.4 210.0 0.0 46.3 0.6 106.6 0.1 0.1 0.1 5.5 5.5 0.0 0.1 0.6 9.0 0.2 0.2 3.7 2.5 0.2 0.0 0.0 0.1 24.8 0.5 0.1 0.0 38.2 0.1 0.6 0.4 53.7 17.2 23.1 2.8 0.4 0.0 0.3 33.4 0.1 1.5 0.0 0.0 0.0 0.9 0.2 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.0 1.6 0.0 0.0 0.2 25.4 27.2 20.5 33.3 22.1 23.2 22.1 24.6 22.8 19.4 27.7 21.6 50.8 0.0 1.1 81.9 0.5 24.0 0.5 0.0 2.2 6.6 1.4 3.3 17.3 1.5 0.0 1.8 4.2 0.6 6.0 0.3 0.0 0.8 1.6 2.8 99.5 32.2 0.0 0.0 7.9 0.0 1.1 123.5 2.0 2.3 0.0 2.5 6.4 1.9 1.5 0.0 1.3 0.7 0.0 0.0 35.6 10.9 165.3 3.1 24.9 45.0 0.7 50.7 23.7 10.1 3.3 0.1 0.1 203.8 2.3 0.7 0.3 0.1 0.7 2.9 1288.5 6.6 288.3 1.9 1.6 0.8 15.3 0.8 4.8 4.0 0.4 1.1 PEAK1 "KIAA2002, sgk269" ENSG00000173517 "Pseudopodium enriched atypical kinase 1" Q9H792 15 77100656-77420144 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 147.4;Excitatory neurons: 162.1;Oligodendrocyte precursor cells: 513.2;Oligodendrocytes: 338.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 4 "NK-cell: 1.8" "Lineage enriched" "Detected in single" 4 "NK-cells: 1.8" "Cell line enhanced" "Detected in all" "TIME: 52.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026313, HPA026517" Approved NA NA "Cluster 15: NK-cells - Transcription" "Cluster 2: Immune cells - Immune response" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 68: Oligodendrocytes - Mixed function" "HPA026313: AB_1856801, HPA026517: AB_1856802" "unprognostic (1.15e-1)" "unprognostic (2.89e-1)" "unprognostic (1.05e-1)" "unprognostic (4.20e-1)" "unprognostic (6.26e-2)" "unprognostic (8.82e-2)" "unprognostic (6.63e-3)" "unprognostic (1.90e-1)" "unprognostic (2.42e-2)" "unprognostic (6.00e-3)" "unprognostic (1.06e-1)" "unprognostic (9.75e-2)" "unprognostic (2.25e-3)" "unprognostic (5.73e-2)" "unprognostic (2.09e-2)" "unprognostic (3.33e-1)" "unprognostic (5.65e-3)" 13.8 4.4 8.9 5.8 13.3 9.1 9.5 5.5 8.8 11.3 1.0 7.8 5.9 7.4 6.4 5.2 5.7 10.0 16.2 8.2 8.4 5.0 3.8 18.0 6.8 6.4 7.8 7.5 4.8 5.4 2.9 16.7 5.8 6.0 8.1 13.7 5.5 7.3 6.7 6.7 7.3 9.9 4.9 29.4 4.9 9.9 11.8 4.7 6.3 8.5 4.7 9.0 7.5 11.7 5.4 7.8 18.1 4.3 33.4 35.7 6.3 28.6 19.7 14.9 14.9 6.3 4.7 4.1 5.0 41.4 5.7 2.6 14.6 4.5 16.9 4.2 7.6 7.7 12.2 3.8 12.2 4.6 3.9 27.6 4.3 28.8 4.8 16.3 42.3 6.6 10.0 4.0 16.1 2.2 2.6 4.9 8.4 3.7 2.1 5.3 10.8 3.0 4.4 9.6 4.0 4.9 11.2 2.3 18.6 19.7 1.7 3.2 52.1 31.5 15.2 13.2 12.2 6.3 9.5 5.9 5.5 10.5 17.3 0.1 0.2 0.4 0.2 0.0 0.4 0.3 0.0 0.0 0.1 0.2 0.1 0.1 0.1 1.8 0.1 0.2 0.0 0.2 8.9 13.3 5.5 8.8 8.2 8.4 6.4 7.8 5.8 4.9 11.8 11.7 48.3 147.4 46.8 101.9 12.6 21.9 7.5 5.6 2.2 18.4 6.1 5.8 46.9 10.0 29.2 1.8 12.5 3.1 12.3 23.9 0.0 6.9 15.1 22.9 19.5 41.2 3.0 10.8 162.1 5.4 2.0 35.6 15.8 10.1 17.7 6.3 31.8 6.0 18.9 20.2 84.4 11.9 2.0 21.3 34.7 13.6 19.9 20.2 12.4 124.6 8.5 28.1 10.3 513.2 338.1 9.8 10.7 16.1 7.0 8.3 15.7 3.7 41.6 20.1 13.1 23.0 37.7 13.6 13.7 5.8 18.0 6.3 8.2 22.6 12.3 7.2 PRAG1 "DKFZp761P0423, NACK, PEAK2, PRAGMIN, SgK223" ENSG00000275342 "PEAK1 related, kinase-activating pseudokinase 1" Q86YV5 8 8317736-8386439 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 35.0;thyroid gland: 23.2" "Cell type enhanced" "Detected in many" "Adipocytes: 45.9;Breast glandular cells: 14.1;Breast myoepithelial cells: 11.0;Hofbauer cells: 18.3" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "cerebellum: 35.0" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "A549: 50.2;NTERA-2: 32.1;SuSa: 32.1" "Low region specificity" "Detected in all" "HPA011776, HPA012066" Uncertain Uncertain "Nucleoli,Focal adhesion sites" NA NA "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 5: NTERA-2 - Transcription" "Cluster 7: Non-specific - Mitochondria" Nucleoli "Focal adhesion sites" "HPA011776: , HPA012066: AB_1847706" "unprognostic (7.04e-3)" "unprognostic (7.90e-2)" "unprognostic (2.32e-1)" "unprognostic (2.95e-2)" "unprognostic (1.60e-1)" "unprognostic (2.92e-1)" "unprognostic (1.05e-1)" "unprognostic (4.78e-3)" "unprognostic (2.64e-3)" "unprognostic (5.19e-2)" "unprognostic (4.95e-2)" "unprognostic (1.78e-1)" "prognostic favorable (4.81e-4)" "unprognostic (5.27e-2)" "unprognostic (1.23e-1)" "unprognostic (5.04e-2)" "unprognostic (5.22e-3)" 8.7 1.0 9.2 5.2 12.0 0.6 9.4 35.0 5.8 2.8 0.0 5.3 11.3 1.7 0.2 5.5 5.6 2.3 6.1 5.3 1.4 3.7 2.7 5.2 8.1 1.2 3.0 3.8 3.3 2.2 1.5 5.7 1.8 2.5 4.1 0.2 5.0 1.5 7.4 7.5 11.6 1.4 0.1 8.4 4.8 2.2 4.6 3.0 23.2 3.4 6.1 2.3 2.8 1.8 6.2 50.2 5.6 0.7 0.0 0.3 14.1 12.8 2.7 4.9 2.0 25.0 14.4 10.2 8.6 6.1 13.5 21.9 1.0 15.3 1.0 0.5 1.6 0.0 6.2 14.2 5.3 1.5 15.4 1.2 9.8 0.8 2.2 2.9 10.2 1.5 0.0 0.1 3.8 8.5 1.4 4.8 32.1 19.5 12.9 6.6 6.0 2.5 7.2 17.5 2.8 1.9 4.9 13.9 5.0 32.1 10.8 6.3 13.7 0.5 12.9 0.0 3.2 0.8 1.1 13.9 3.1 3.4 7.4 0.0 0.2 0.9 0.4 0.0 0.3 1.2 0.6 0.2 0.3 0.9 1.6 1.3 0.0 0.5 0.8 1.9 0.0 0.2 9.2 12.0 35.0 5.8 5.3 1.4 1.2 3.0 1.8 0.1 4.6 1.8 45.9 9.6 6.5 0.0 1.9 0.0 0.0 0.0 0.0 0.0 14.1 11.0 0.0 0.0 0.0 0.0 0.0 7.5 5.3 0.0 0.0 9.0 0.0 3.0 1.4 5.6 0.0 0.0 0.0 3.1 7.2 2.5 0.0 1.7 2.5 1.7 0.0 0.0 18.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 0.0 0.0 1.0 0.0 0.0 0.0 0.0 6.9 0.0 0.0 0.9 0.0 0.0 2.7 1.5 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.8 2.3 7.4 0.0 0.0 PTK2 "FADK, FAK, FAK1, PPP1R71" ENSG00000169398 "Protein tyrosine kinase 2" Q05397 8 140657900-141002216 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Angiogenesis "Developmental protein, Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 295.2;Excitatory neurons: 584.9;Oligodendrocyte precursor cells: 353.9;Oligodendrocytes: 791.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001842, CAB004036, HPA029671" Approved Supported "Vesicles,Focal adhesion sites,Cytosol" NA Yes 25000 "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 57: Non-specific - Angiogenesis" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Focal adhesion sites" "Vesicles, Cytosol" "CAB004036: AB_2269034, HPA001842: AB_1855891, HPA029671: AB_10610288" "prognostic unfavorable (3.21e-4)" "unprognostic (3.86e-2)" "unprognostic (1.95e-1)" "prognostic unfavorable (9.11e-4)" "unprognostic (1.93e-1)" "unprognostic (2.28e-1)" "unprognostic (3.02e-2)" "unprognostic (1.27e-1)" "unprognostic (1.97e-1)" "unprognostic (2.96e-2)" "unprognostic (1.06e-2)" "unprognostic (2.38e-1)" "unprognostic (2.80e-2)" "unprognostic (2.94e-2)" "unprognostic (1.11e-1)" "unprognostic (1.53e-1)" "unprognostic (2.90e-2)" 51.0 40.4 83.8 19.5 115.1 6.7 42.1 62.4 99.9 40.3 51.0 37.2 25.8 37.3 49.7 25.6 34.0 32.1 36.9 84.5 77.3 42.6 30.1 39.4 25.3 79.1 87.6 33.7 32.1 53.1 21.3 74.2 81.0 34.0 35.3 35.5 39.9 41.6 38.7 29.6 29.5 37.6 67.6 22.8 32.8 38.9 86.7 11.9 38.7 39.4 25.8 43.9 34.0 154.5 52.6 81.9 111.0 40.3 45.8 48.8 71.6 50.8 70.0 46.3 45.3 35.9 42.1 31.7 111.7 65.3 65.0 60.3 66.1 116.0 69.6 0.3 30.8 70.1 44.3 50.0 62.5 0.1 31.8 33.4 55.8 58.0 81.0 121.5 139.0 44.0 72.0 0.8 62.9 91.0 0.9 0.7 43.2 113.2 90.3 46.8 60.9 1.5 97.7 117.3 43.9 54.8 79.0 25.0 52.0 97.2 59.2 1.2 84.9 45.2 85.5 54.0 58.1 0.0 0.6 3.4 58.7 0.6 62.9 1.6 3.3 0.0 0.2 1.4 0.0 5.3 0.6 0.0 4.5 6.3 4.4 1.6 1.3 4.7 0.8 6.1 0.2 3.9 83.8 115.1 62.4 99.9 84.5 77.3 79.1 87.6 81.0 67.6 86.7 154.5 71.3 32.1 33.1 295.2 20.6 33.3 70.1 36.3 64.9 55.2 29.3 23.5 29.6 32.9 32.1 55.2 60.5 37.0 8.0 23.1 23.5 27.2 68.4 29.3 43.3 54.3 25.8 8.4 584.9 23.3 53.7 37.2 37.8 46.5 9.5 84.7 37.5 15.7 8.1 67.3 263.6 23.0 30.5 15.2 15.9 38.8 23.9 19.4 24.9 159.3 3.9 40.9 0.0 353.9 791.4 43.1 23.5 21.8 1.7 82.4 29.3 25.6 33.7 55.0 98.6 32.7 128.4 88.9 65.5 42.8 25.9 33.2 3.4 67.0 24.1 87.3 PTK2B "CADTK, CAKB, FAK2, PTK, PYK2, RAFTK" ENSG00000120899 "Protein tyrosine kinase 2 beta" Q14289 8 27311482-27459391 "Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Adaptive immunity, Angiogenesis, Immunity" "Kinase, Transferase, Tyrosine-protein kinase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 106.3;brain: 102.9" "Cell type enhanced" "Detected in many" "Excitatory neurons: 109.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Daudi: 127.4;REH: 141.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003850, HPA026091, HPA026276" Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 10: Brain - Neuronal signaling" "Cluster 14: REH - Unknown function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane, Cytosol" "CAB003850: AB_562205, HPA026091: AB_10599739, HPA026276: AB_10601234" "unprognostic (2.36e-2)" "prognostic favorable (3.32e-4)" "unprognostic (1.06e-1)" "unprognostic (7.36e-3)" "unprognostic (3.72e-2)" "unprognostic (3.11e-2)" "unprognostic (2.70e-2)" "unprognostic (2.13e-2)" "unprognostic (3.23e-1)" "unprognostic (1.45e-1)" "unprognostic (5.74e-2)" "unprognostic (3.32e-1)" "unprognostic (2.40e-3)" "unprognostic (1.44e-1)" "unprognostic (1.38e-1)" "prognostic favorable (5.11e-4)" "unprognostic (3.33e-3)" 19.7 10.8 46.9 52.6 54.4 106.3 11.5 22.8 102.9 11.5 38.3 29.8 34.1 9.9 8.9 19.2 15.6 12.7 10.6 96.3 8.5 15.9 15.2 28.6 78.3 0.0 26.0 4.7 12.6 7.1 13.7 8.0 0.0 25.5 23.5 4.4 26.6 12.3 5.0 45.2 48.8 10.7 0.2 78.3 22.2 9.5 27.0 86.0 12.5 5.4 73.6 21.0 15.1 37.0 38.2 10.4 2.8 3.0 76.6 5.5 21.5 2.9 1.9 1.9 2.7 9.9 21.5 127.4 4.0 5.8 3.1 34.3 1.1 31.3 1.1 8.7 0.8 26.4 10.6 2.0 15.7 28.5 45.5 41.6 46.0 2.6 17.3 13.0 1.0 36.0 31.7 85.6 2.1 4.0 49.1 57.0 2.2 33.0 2.6 141.2 0.7 88.3 8.5 29.5 19.2 3.5 13.4 9.3 5.0 6.5 11.5 72.1 17.5 1.3 2.8 2.5 1.0 68.0 32.0 68.9 5.2 60.6 2.4 47.3 48.4 36.9 33.9 43.0 22.2 46.0 17.0 24.3 36.1 46.6 20.8 25.9 45.8 29.0 53.5 11.7 18.2 50.1 46.9 54.4 22.8 102.9 96.3 8.5 0.0 26.0 0.0 0.2 27.0 37.0 6.9 3.2 29.8 16.6 64.3 37.7 38.7 19.7 6.8 5.4 5.9 7.7 3.7 8.6 13.0 14.7 0.0 2.9 33.4 65.5 0.0 8.0 1.2 7.1 1.8 9.6 7.8 20.2 109.2 8.3 26.5 3.5 22.4 5.3 28.5 1.1 5.0 24.1 23.1 8.4 9.2 21.9 10.2 68.4 32.1 1.0 1.5 55.3 8.8 22.5 62.5 2.8 70.0 7.5 15.1 13.3 42.0 0.7 68.1 18.6 44.6 16.1 13.9 3.9 0.0 3.3 3.3 4.2 6.4 4.8 30.1 1.9 46.6 1.0 18.1 17.9 PTK6 BRK ENSG00000101213 "Protein tyrosine kinase 6" Q13882 20 63528001-63537376 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 109.4;skin 1: 53.9;vagina: 43.2" "Cell type enhanced" "Detected in many" "Distal enterocytes: 132.1;Gastric mucus-secreting cells: 59.1;Intestinal goblet cells: 42.5;Paneth cells: 97.6;Proximal enterocytes: 80.2;Squamous epithelial cells: 48.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "A-431: 22.1;CAPAN-2: 41.4;HaCaT: 33.9;hTCEpi: 45.0;OE19: 57.0;RT4: 26.4;T-47d: 25.2" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB032952, HPA036070, HPA036071" Approved Supported "Nucleoplasm,Nuclear bodies,Plasma membrane,Cytosol" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "Nuclear bodies, Plasma membrane, Cytosol" "CAB032952: AB_634461, HPA036070: AB_10602292, HPA036071: AB_10669982" "unprognostic (2.32e-2)" "unprognostic (1.36e-1)" "unprognostic (1.05e-1)" "unprognostic (2.42e-2)" "unprognostic (1.41e-1)" "unprognostic (1.35e-1)" "unprognostic (1.04e-1)" "unprognostic (2.29e-1)" "unprognostic (3.03e-1)" "unprognostic (3.72e-2)" "prognostic unfavorable (1.96e-4)" "unprognostic (1.28e-1)" "prognostic unfavorable (1.26e-9)" "unprognostic (4.19e-2)" "unprognostic (1.74e-1)" "unprognostic (1.73e-1)" "unprognostic (4.24e-2)" 0.5 0.1 0.6 3.6 1.7 0.8 3.8 2.9 1.7 19.8 0.0 26.5 28.9 0.4 0.1 109.4 0.4 3.5 0.2 0.6 0.9 0.8 5.2 2.6 0.6 1.6 1.0 0.3 3.6 0.0 0.2 0.3 1.7 3.1 15.7 0.8 19.1 0.6 0.6 53.9 22.2 0.8 0.6 0.8 26.2 0.3 1.1 0.3 0.2 0.0 6.4 9.8 43.2 5.4 22.1 2.6 0.3 0.3 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.5 41.4 0.1 7.2 0.0 0.1 33.9 0.0 0.1 0.0 5.4 0.4 0.0 10.2 0.1 0.1 0.0 6.7 0.0 45.0 0.0 0.2 0.2 0.0 0.1 0.2 2.5 0.2 12.5 0.0 0.2 0.2 57.0 15.5 0.1 1.2 0.5 0.0 26.4 0.3 2.2 2.6 8.1 0.0 0.1 25.2 1.6 0.2 0.3 0.4 0.8 0.3 0.5 0.1 0.1 0.4 0.5 1.1 0.4 0.7 0.1 0.1 0.5 0.5 0.3 0.1 0.0 1.3 0.3 0.1 0.1 0.3 0.0 0.4 0.1 0.1 0.3 0.6 1.7 2.9 1.7 0.6 0.9 1.6 1.0 1.7 0.6 1.1 5.4 0.3 12.8 25.6 0.3 1.4 5.9 2.6 7.7 5.2 2.2 7.0 4.3 0.4 12.8 14.9 0.0 2.1 0.2 0.2 132.1 0.0 1.4 0.2 0.4 0.5 3.2 5.4 0.0 0.1 1.6 0.2 1.4 59.1 1.3 9.5 0.2 0.4 1.7 0.6 0.0 0.1 42.5 2.0 2.2 2.0 0.0 0.3 2.6 0.0 0.0 1.0 1.6 1.0 0.0 0.8 17.6 97.6 0.0 0.1 1.5 80.2 0.2 8.9 3.7 0.0 2.3 1.1 0.2 0.3 48.0 15.5 0.1 2.0 0.2 32.1 15.9 PTK7 CCK4 ENSG00000112655 "Protein tyrosine kinase 7 (inactive)" Q13308 6 43076307-43161719 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Cell adhesion, Wnt signaling pathway" Receptor "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Early spermatids: 317.3;Endometrial stromal cells: 84.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 10 "plasmacytoid DC: 13.5" "Lineage enriched" "Detected in many" 10 "dendritic cells: 13.5" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003222 Approved "Secreted to blood" NA NA 12000000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 29: Early spermatids - Spermatogenesis" "HPA003222: AB_1079713" "unprognostic (1.80e-1)" "unprognostic (7.49e-3)" "unprognostic (6.22e-2)" "unprognostic (2.03e-1)" "unprognostic (1.65e-1)" "unprognostic (1.15e-2)" "unprognostic (5.85e-3)" "unprognostic (9.81e-3)" "unprognostic (1.47e-3)" "unprognostic (7.15e-2)" "unprognostic (5.11e-3)" "unprognostic (8.17e-2)" "unprognostic (3.37e-2)" "unprognostic (1.73e-1)" "unprognostic (3.61e-1)" "unprognostic (9.12e-2)" "unprognostic (5.70e-3)" 15.0 5.0 9.6 6.7 8.4 2.8 17.5 8.5 8.9 69.5 36.0 9.4 6.5 87.4 87.1 30.1 38.2 24.7 8.8 8.7 10.8 29.3 1.6 33.9 3.9 10.2 11.4 85.3 16.4 13.0 21.1 48.8 8.7 37.9 8.5 6.0 36.7 25.4 0.6 34.6 9.5 38.7 9.0 27.8 12.2 41.7 11.2 30.4 23.0 1.5 6.4 22.3 43.6 8.2 9.1 2.5 83.6 141.6 88.0 89.9 119.4 94.2 145.5 77.0 99.4 77.0 31.0 0.2 74.0 107.3 56.4 99.5 38.0 87.5 49.3 0.7 52.0 8.5 17.1 105.2 132.5 0.3 0.4 129.1 77.4 103.2 32.6 135.8 10.1 35.0 6.2 0.2 36.4 7.0 32.5 12.6 39.1 0.8 7.0 33.3 119.0 0.3 61.0 42.4 48.3 91.6 14.8 1.5 50.0 87.8 51.9 19.5 6.8 84.1 53.1 0.4 51.0 0.5 0.9 3.2 19.1 0.3 14.1 0.4 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.4 0.0 0.0 1.4 0.2 0.7 0.0 13.5 0.0 0.8 9.6 8.4 8.5 8.9 8.7 10.8 10.2 11.4 8.7 9.0 11.2 8.2 3.0 16.0 13.1 10.7 0.8 17.3 19.9 40.4 27.9 4.3 23.5 32.5 1.6 5.7 14.6 12.9 56.3 19.1 6.3 1.7 1.9 21.0 317.3 23.5 84.7 8.7 21.6 4.0 8.7 6.9 2.2 30.0 8.6 25.2 1.3 25.3 2.2 0.0 3.5 0.0 5.3 3.9 42.7 0.0 9.8 48.9 18.3 4.1 16.0 1.0 1.0 20.1 0.0 3.5 1.4 10.5 4.1 18.4 1.4 11.8 0.6 0.6 15.4 2.2 13.1 8.7 27.9 2.8 21.2 13.7 10.4 8.2 3.0 17.7 6.3 11.8 PTP4A1 "PRL-1, PRL1, PTPCAAX1" ENSG00000112245 "Protein tyrosine phosphatase 4A1" Q93096 6 63521746-63583436 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle" "Developmental protein, Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 493.7" "Cell type enriched" "Detected in all" 4 "Late spermatids: 3071.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Hep G2: 533.9" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA003281 Approved NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 25: Spermatids - Spermatogenesis" "HPA003281: AB_1855903" "unprognostic (8.63e-2)" "prognostic unfavorable (5.53e-4)" "unprognostic (9.05e-2)" "unprognostic (7.96e-2)" "unprognostic (2.79e-2)" "unprognostic (2.71e-2)" "unprognostic (6.12e-2)" "unprognostic (1.96e-1)" "unprognostic (5.28e-2)" "unprognostic (2.33e-2)" "unprognostic (6.62e-3)" "unprognostic (1.23e-2)" "unprognostic (1.07e-2)" "unprognostic (6.64e-2)" "unprognostic (1.28e-1)" "unprognostic (2.10e-2)" "unprognostic (1.11e-2)" 39.4 140.5 24.1 37.4 29.5 227.4 31.5 30.9 35.9 41.5 28.3 107.9 55.1 43.8 15.3 53.5 34.6 58.9 31.7 24.7 37.5 50.5 493.7 54.8 24.4 32.5 28.0 54.7 69.5 16.1 41.1 72.5 32.1 44.2 110.1 22.5 68.2 21.0 300.0 66.0 50.8 56.6 34.9 19.4 55.2 62.5 27.9 26.2 39.2 113.0 24.6 51.6 33.6 44.8 71.5 122.9 106.2 128.3 85.8 77.2 239.1 113.9 97.6 58.4 79.2 103.5 45.4 65.1 50.6 88.7 95.7 41.8 97.0 197.9 94.3 61.0 51.6 43.8 320.2 533.9 175.7 118.6 57.7 91.3 383.6 124.7 320.5 63.5 80.3 65.0 106.1 148.7 151.5 140.9 52.4 69.1 50.6 91.0 53.7 70.9 53.4 60.5 132.4 120.6 44.7 62.5 278.5 71.8 140.1 156.9 59.8 122.0 77.5 132.9 130.6 89.5 122.3 90.7 94.9 121.7 60.9 72.5 154.1 45.4 20.4 15.1 12.8 21.3 20.1 12.9 14.5 14.3 17.2 10.7 12.8 12.9 48.4 16.3 16.6 9.1 18.8 15.4 24.1 29.5 30.9 35.9 24.7 37.5 32.5 28.0 32.1 34.9 27.9 44.8 33.3 22.4 90.3 4.6 105.4 681.3 268.7 94.1 261.8 22.3 98.4 55.4 78.5 207.3 83.0 75.4 16.7 248.7 99.8 336.5 80.3 186.9 716.1 189.8 68.8 47.0 129.6 30.9 11.7 193.9 215.1 90.8 178.4 279.5 63.0 41.2 41.4 528.8 98.6 11.8 9.9 253.4 63.1 71.6 236.5 3071.4 28.6 99.7 170.7 5.6 47.4 22.0 15.5 9.5 20.4 151.8 196.9 24.0 110.6 166.4 181.3 112.1 61.2 24.6 6.6 44.4 110.2 47.2 26.3 181.8 641.0 459.6 123.4 79.1 214.6 164.1 PTP4A2 "HU-PP-1, OV-1, PRL-2, PRL2, ptp-IV1a, PTP4A, PTPCAAX2" ENSG00000184007 "Protein tyrosine phosphatase 4A2" Q12974 1 31906421-31944856 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Urothelial cells: 917.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003281, CAB011204" Uncertain NA NA 490000 "Cluster 51: Monocytes - Innate immune response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 22: Epithelial cell types - Mixed function" "CAB011204: AB_532271, HPA003281: AB_1855903" "unprognostic (2.67e-2)" "unprognostic (6.36e-2)" "unprognostic (3.15e-3)" "unprognostic (3.73e-2)" "unprognostic (2.70e-2)" "unprognostic (6.20e-2)" "prognostic unfavorable (2.62e-5)" "unprognostic (6.90e-2)" "unprognostic (4.63e-2)" "unprognostic (5.12e-2)" "unprognostic (1.99e-2)" "unprognostic (1.03e-1)" "prognostic unfavorable (5.10e-11)" "unprognostic (1.16e-2)" "unprognostic (3.81e-1)" "unprognostic (2.89e-1)" "prognostic favorable (2.72e-5)" 158.2 71.0 269.3 147.2 322.8 295.9 126.6 221.3 399.7 85.5 146.1 125.6 114.2 73.1 70.5 66.9 81.5 100.8 169.8 209.1 255.7 91.6 117.1 105.9 166.0 262.5 286.3 85.3 99.8 72.3 66.3 91.1 270.0 88.3 127.1 52.3 104.1 88.9 306.4 53.1 103.1 99.7 264.3 116.1 113.9 98.9 264.1 489.2 163.7 186.3 172.4 186.7 72.9 400.2 297.7 166.6 163.1 305.9 321.5 321.2 109.1 290.3 387.9 218.5 224.3 144.1 409.3 532.0 214.0 393.2 245.2 118.3 172.2 161.9 398.1 479.8 94.6 371.6 282.7 155.6 340.4 304.7 353.1 319.6 127.6 305.6 297.9 224.8 220.7 425.1 482.4 195.4 283.3 138.5 930.8 149.2 221.7 220.3 238.7 165.8 275.2 222.3 153.8 519.7 160.1 115.3 296.9 199.1 328.8 265.9 560.5 167.4 243.5 257.0 224.7 403.8 319.8 215.3 336.0 259.2 263.5 246.7 261.6 204.3 50.9 87.4 74.8 105.3 58.4 44.2 63.4 85.1 46.0 39.6 40.8 69.4 53.5 60.7 148.0 33.6 57.4 60.7 269.3 322.8 221.3 399.7 209.1 255.7 262.5 286.3 270.0 264.3 264.1 400.2 206.8 121.8 126.5 25.5 199.0 194.1 502.4 87.8 136.1 60.5 287.0 125.5 187.0 153.0 117.0 202.3 60.5 50.0 360.2 247.3 191.7 154.9 48.1 132.4 135.8 131.2 128.3 209.3 41.6 185.4 128.7 158.2 141.2 218.2 87.5 118.0 94.6 169.3 125.0 99.3 33.9 204.0 65.1 219.8 405.2 51.2 176.7 336.0 115.6 38.4 488.3 145.8 568.5 30.7 176.4 185.6 191.3 175.3 270.0 623.3 126.9 170.3 74.7 56.3 131.5 134.1 135.2 130.6 107.5 148.7 196.5 160.1 281.1 67.0 199.7 917.5 PTP4A3 "PRL-3, PRL-R, PRL3" ENSG00000184489 "Protein tyrosine phosphatase 4A3" O75365 8 141391995-141432454 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "heart muscle: 640.3;pituitary gland: 207.5;skeletal muscle: 738.1" "Cell type enhanced" "Detected in many" "Bipolar cells: 102.9;Cardiomyocytes: 272.8;Cone photoreceptor cells: 123.0;Rod photoreceptor cells: 226.5;Smooth muscle cells: 140.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 55.0;non-classical monocyte: 54.1" "Group enriched" "Detected in all" 6 "granulocytes: 55.0;monocytes: 54.1" "Cell line enhanced" "Detected in many" "HDLM-2: 128.7;Karpas-707: 45.9;RPMI-8226: 38.1;U-266/84: 42.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003281 Uncertain NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 38: Heart - Muscle contraction" "Cluster 44: HDLM-2 - Immune response" "Cluster 48: Smooth muscle cells - ECM organization" "HPA003281: AB_1855903" "unprognostic (1.09e-1)" "unprognostic (3.70e-1)" "unprognostic (2.55e-2)" "unprognostic (1.10e-3)" "unprognostic (2.08e-1)" "unprognostic (6.18e-2)" "unprognostic (3.61e-2)" "unprognostic (2.27e-2)" "unprognostic (1.08e-1)" "unprognostic (2.50e-1)" "unprognostic (5.73e-3)" "unprognostic (2.33e-2)" "prognostic unfavorable (1.81e-5)" "unprognostic (2.25e-1)" "unprognostic (1.12e-2)" "unprognostic (2.28e-2)" "unprognostic (1.77e-1)" 48.6 16.6 11.4 2.0 9.8 0.7 43.3 9.0 14.1 87.3 9.2 70.7 2.1 69.9 3.0 15.1 67.2 1.4 640.3 10.1 10.6 48.9 9.8 58.4 1.1 10.5 10.3 46.8 116.2 2.6 207.5 2.3 10.7 73.6 0.7 36.0 29.9 2.1 738.1 22.8 37.4 4.4 9.3 56.8 99.7 22.0 13.3 1.1 35.2 62.1 1.3 40.5 35.7 9.2 0.3 0.9 0.6 0.1 0.0 0.2 0.1 0.5 0.1 0.0 0.0 0.1 2.3 0.0 9.8 0.1 0.1 0.0 0.1 0.1 0.0 128.7 1.9 5.2 0.2 1.8 0.5 0.0 0.2 0.1 0.4 0.0 0.0 0.0 0.4 1.0 3.1 45.9 0.1 11.3 0.7 0.2 2.1 1.0 0.7 19.3 0.1 38.1 0.0 0.1 11.4 3.9 0.6 0.1 2.6 1.2 1.8 0.0 0.5 0.1 2.2 0.1 0.0 11.6 42.0 0.3 0.1 2.8 0.1 1.5 3.3 12.5 3.1 28.2 1.8 5.1 5.8 3.0 2.0 1.2 6.5 3.4 55.0 1.5 54.1 8.6 5.3 5.1 11.4 9.8 9.0 14.1 10.1 10.6 10.5 10.3 10.7 9.3 13.3 9.2 52.7 3.2 44.5 5.5 21.1 9.9 5.2 23.7 7.4 102.9 9.8 7.4 272.8 4.3 8.3 7.3 123.0 0.3 5.6 0.8 9.8 8.2 10.9 2.0 3.1 57.7 10.2 0.8 5.3 62.9 0.3 21.7 5.6 2.0 1.3 6.6 15.0 0.3 4.1 15.2 10.3 2.9 26.4 2.8 20.1 7.1 3.7 4.0 21.4 8.4 12.8 36.7 2.1 2.5 0.7 10.8 0.2 1.9 79.8 11.9 0.2 5.0 1.1 226.5 32.9 17.1 140.8 4.4 24.8 1.8 10.2 0.3 13.7 3.4 3.0 3.6 PTPDC1 "FLJ37312, PTP9Q22" ENSG00000158079 "Protein tyrosine phosphatase domain containing 1" A2A3K4 9 94030794-94109856 "Metabolic proteins, Predicted intracellular proteins" "Cilium biogenesis/degradation" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 18.3" "Cell type enhanced" "Detected in many" "Excitatory neurons: 36.1;Oligodendrocytes: 82.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016747, HPA026832" Approved Enhanced Nucleoplasm NA NA "Cluster 32: T-cells - Unknown function" "Cluster 6: Brain - Smell perception" "Cluster 30: Epithelial cell lines - Translation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA016747: AB_1855908, HPA026832: AB_10602917" "unprognostic (3.99e-2)" "unprognostic (2.54e-1)" "unprognostic (1.74e-1)" "unprognostic (4.91e-2)" "unprognostic (1.94e-1)" "unprognostic (3.64e-2)" "unprognostic (1.90e-3)" "unprognostic (4.71e-1)" "unprognostic (2.43e-1)" "unprognostic (2.56e-1)" "unprognostic (3.49e-2)" "unprognostic (3.55e-2)" "unprognostic (2.48e-2)" "unprognostic (2.45e-2)" "unprognostic (2.17e-1)" "unprognostic (1.28e-1)" "unprognostic (2.61e-2)" 3.7 5.7 7.8 2.2 14.1 0.7 3.1 9.7 12.4 3.1 2.5 4.3 1.4 3.1 2.2 2.0 3.3 2.2 7.0 8.0 8.9 3.3 1.5 4.4 1.9 10.9 11.5 3.0 5.9 3.6 6.7 1.7 10.8 3.2 2.8 4.4 2.9 2.0 4.8 3.1 2.3 4.1 6.7 1.8 4.3 7.8 10.2 1.8 3.3 6.7 1.9 2.5 2.7 18.3 6.1 2.7 4.7 6.1 5.8 7.9 6.2 4.4 3.0 4.4 3.7 2.6 5.0 5.1 2.9 3.4 10.1 4.7 4.9 2.8 4.3 6.8 1.3 1.2 7.7 2.8 7.4 1.4 3.8 7.9 10.0 6.7 9.2 2.6 4.7 8.3 3.0 0.0 8.4 3.3 5.2 2.2 3.3 5.0 4.8 5.6 9.3 0.0 2.4 1.5 4.1 5.1 6.1 5.7 9.5 6.2 3.1 2.5 6.7 5.8 3.5 9.1 5.4 7.2 8.4 0.7 4.3 2.5 8.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 7.8 14.1 9.7 12.4 8.0 8.9 10.9 11.5 10.8 6.7 10.2 18.3 5.7 0.0 7.7 19.2 4.7 4.8 3.0 2.2 5.7 10.7 2.3 3.3 11.3 5.7 1.4 5.5 10.4 0.4 2.6 2.1 3.9 3.1 11.7 2.3 7.3 5.8 3.5 0.8 36.1 2.9 2.0 8.1 14.3 3.1 5.7 6.7 4.2 1.0 3.1 5.0 27.0 2.6 4.1 1.0 4.6 6.2 3.7 3.6 3.6 14.0 0.5 2.2 0.0 18.6 82.6 6.1 2.9 14.3 2.0 1.4 1.1 1.7 2.1 9.8 19.7 7.4 5.5 21.0 20.8 4.7 4.3 0.3 4.0 2.3 2.3 1.8 PTPMT1 "DUSP23, MOSP, PLIP" ENSG00000110536 "Protein tyrosine phosphatase mitochondrial 1" Q8WUK0 11 47565430-47573461 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 235.1;Late spermatids: 640.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043932, HPA060060" Approved Enhanced Mitochondria NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 71: Testis - DNA repair" "Cluster 6: T47d - Mammary gland" "Cluster 25: Spermatids - Spermatogenesis" Mitochondria "HPA043932: AB_2678738, HPA060060: " "unprognostic (6.61e-2)" "unprognostic (2.09e-1)" "unprognostic (1.28e-1)" "unprognostic (2.37e-3)" "unprognostic (1.02e-1)" "unprognostic (1.26e-2)" "prognostic unfavorable (3.04e-5)" "unprognostic (3.29e-2)" "unprognostic (2.77e-2)" "unprognostic (1.93e-3)" "unprognostic (6.76e-2)" "unprognostic (1.72e-1)" "unprognostic (2.68e-3)" "unprognostic (1.21e-1)" "unprognostic (5.39e-1)" "unprognostic (2.17e-2)" "unprognostic (1.75e-1)" 38.8 56.5 15.0 5.3 16.1 9.0 37.4 15.8 17.4 31.1 16.6 31.0 7.6 32.8 7.8 34.8 29.5 4.2 27.7 14.4 16.5 37.6 40.6 36.5 6.1 15.6 16.3 28.0 44.7 9.6 41.9 6.7 15.8 32.7 3.9 4.2 37.1 5.9 41.0 28.1 23.4 4.7 16.0 28.9 39.2 105.4 17.0 4.3 30.6 5.8 4.9 27.5 28.1 16.0 34.5 19.4 2.3 17.8 17.5 11.4 7.0 20.1 17.1 19.4 16.8 27.9 17.6 27.9 22.1 14.7 16.8 30.6 16.9 20.4 16.6 31.4 57.3 12.9 43.8 43.4 25.7 25.2 17.1 12.7 21.9 8.8 24.0 11.2 13.7 26.2 32.6 19.5 14.2 65.4 21.4 41.0 18.8 3.9 37.7 38.6 16.7 22.3 22.5 23.3 15.5 21.4 33.8 11.1 23.2 7.2 53.1 32.7 16.6 13.6 23.3 28.6 33.1 27.1 22.6 18.6 13.6 23.3 10.0 11.2 38.0 38.2 24.8 36.8 23.0 33.7 22.7 26.2 44.9 30.3 22.3 21.0 3.1 26.1 34.6 64.6 28.5 28.8 15.0 16.1 15.8 17.4 14.4 16.5 15.6 16.3 15.8 16.0 17.0 16.0 26.8 22.4 35.0 14.4 31.8 17.8 15.8 58.5 34.1 14.4 64.9 78.4 5.8 45.8 38.6 40.5 4.2 72.2 34.7 19.9 72.4 95.3 235.1 48.0 23.9 24.6 31.3 30.1 8.2 85.8 66.3 23.9 28.1 25.6 17.1 16.5 29.6 39.8 62.4 5.0 10.8 45.7 48.8 32.6 21.2 640.8 46.6 45.6 46.2 6.5 56.2 74.9 41.2 9.5 14.6 106.2 38.8 46.6 61.0 26.0 37.9 72.8 57.2 15.7 19.7 17.3 28.1 179.8 28.6 55.0 17.3 76.8 25.9 21.3 62.7 22.0 PTPN1 PTP1B ENSG00000196396 "Protein tyrosine phosphatase non-receptor type 1" P18031 20 50510321-50585241 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Alveolar cells type 1: 227.6;monocytes: 207.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009329, HPA012542, CAB015217" Approved Enhanced "Endoplasmic reticulum" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 65: Plasmacytoid DCs - Unknown function" "Endoplasmic reticulum" "CAB009329: AB_2174944, CAB015217: , HPA012542: AB_1855915" "unprognostic (1.67e-1)" "unprognostic (7.78e-2)" "unprognostic (1.48e-1)" "unprognostic (1.05e-2)" "unprognostic (1.14e-1)" "unprognostic (3.44e-2)" "unprognostic (2.98e-3)" "unprognostic (3.95e-2)" "unprognostic (2.40e-2)" "unprognostic (6.47e-3)" "unprognostic (5.87e-2)" "unprognostic (1.67e-1)" "unprognostic (1.66e-2)" "unprognostic (6.70e-2)" "unprognostic (2.99e-2)" "unprognostic (1.49e-1)" "unprognostic (2.58e-2)" 26.3 30.8 13.0 44.5 14.0 55.4 22.1 12.3 14.7 23.2 28.6 24.8 13.9 23.0 18.7 29.6 22.0 23.1 31.9 17.5 13.0 46.7 21.0 55.2 52.9 16.1 14.4 25.6 15.9 48.3 19.7 34.2 13.7 25.0 18.8 9.9 18.9 18.2 35.4 23.9 28.3 21.9 13.7 46.5 21.0 18.3 14.2 35.5 18.7 21.6 52.6 35.8 23.5 14.1 66.1 32.4 38.4 26.6 24.6 33.6 54.5 43.2 40.8 123.8 44.9 96.1 134.3 32.5 74.8 40.0 48.7 56.9 30.8 123.8 78.2 48.5 27.6 45.9 30.9 51.3 49.0 48.2 60.2 39.6 84.9 55.9 68.2 54.3 72.3 38.5 81.5 28.9 68.3 36.5 52.1 38.1 20.4 36.2 44.2 45.6 44.6 31.1 71.2 48.4 30.8 35.3 62.0 77.6 71.3 32.1 50.4 50.9 108.2 107.3 43.1 48.8 54.2 31.4 27.3 38.9 67.1 32.3 40.6 19.8 7.1 25.2 12.9 12.1 9.5 19.2 10.8 10.0 7.1 17.4 8.9 9.8 15.4 5.3 22.8 11.8 9.4 8.7 13.0 14.0 12.3 14.7 17.5 13.0 16.1 14.4 13.7 13.7 14.2 14.1 34.0 227.6 83.6 22.9 147.8 86.0 61.7 37.1 56.3 25.1 23.9 24.4 30.0 11.5 40.0 36.8 47.9 54.0 68.7 26.1 23.5 26.2 67.7 45.0 44.0 36.3 18.6 32.0 61.6 19.3 20.9 52.1 32.1 65.9 70.8 14.2 41.4 20.8 37.4 43.7 43.3 16.4 20.3 40.6 169.5 37.4 14.0 100.7 37.4 32.8 207.8 12.1 38.1 27.6 42.1 41.7 14.5 12.0 178.7 26.6 8.9 65.2 30.2 27.5 19.7 55.5 57.7 20.8 24.5 48.7 47.2 54.3 83.8 44.3 14.6 53.5 PTPN11 "BPTP3, NS1, PTP2C, SH-PTP2, SHP-2, SHP2" ENSG00000179295 "Protein tyrosine phosphatase non-receptor type 11" Q06124 12 112418351-112509918 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Hydrolase, Protein phosphatase" "Cancer-related genes, Deafness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB005377 Approved Supported "Nucleoplasm,Nucleoli rim,Actin filaments,Cytosol" NA NA 74000 "Cluster 6: Non-specific - Transcription" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 54: Cardiomyocytes - Muscle contraction" "Nucleoplasm, Nucleoli rim" "Actin filaments, Cytosol" "CAB005377: AB_632401" "unprognostic (2.18e-3)" "unprognostic (1.73e-3)" "unprognostic (5.62e-2)" "unprognostic (1.19e-1)" "unprognostic (1.63e-2)" "unprognostic (2.27e-1)" "unprognostic (6.05e-2)" "unprognostic (4.25e-2)" "unprognostic (3.55e-2)" "unprognostic (1.88e-1)" "unprognostic (2.22e-2)" "unprognostic (8.85e-2)" "unprognostic (3.75e-3)" "unprognostic (1.66e-1)" "unprognostic (2.46e-1)" "unprognostic (3.62e-2)" "unprognostic (1.80e-2)" 62.9 36.6 74.6 34.7 91.7 46.3 37.6 72.7 115.7 37.9 38.4 32.5 27.6 37.8 28.7 38.9 24.3 29.4 68.7 66.1 85.6 39.7 53.0 34.4 35.6 79.0 84.1 26.2 31.6 53.4 16.1 38.0 85.7 35.2 30.6 51.8 25.9 42.4 75.1 32.1 26.1 45.7 83.4 26.7 30.4 18.2 81.7 35.5 46.8 64.0 32.5 40.1 23.5 106.3 116.9 107.6 77.0 73.4 109.7 106.1 92.7 136.4 148.2 105.5 78.5 107.7 43.4 124.5 69.4 127.4 66.7 68.1 100.1 121.6 173.8 93.1 85.0 181.5 102.6 59.8 109.2 145.8 108.0 86.6 119.6 113.6 159.8 101.3 88.7 92.0 140.2 41.3 103.3 83.2 101.0 69.7 94.1 112.3 73.4 102.4 114.6 70.5 97.3 126.7 53.3 66.1 133.7 99.8 85.2 77.6 114.8 97.8 108.1 122.9 110.0 74.2 121.8 79.4 141.6 120.2 102.2 99.7 117.7 32.2 11.7 16.8 14.8 10.2 14.0 18.1 13.3 12.4 13.6 20.8 15.3 11.9 10.7 12.6 13.7 18.3 10.9 7.2 74.6 91.7 72.7 115.7 66.1 85.6 79.0 84.1 85.7 83.4 81.7 106.3 49.0 60.9 68.2 27.7 25.8 25.6 39.9 25.3 20.5 29.9 40.5 32.4 131.6 24.3 41.8 36.8 16.7 23.5 34.2 25.4 33.2 37.5 63.1 31.3 92.6 46.2 13.1 21.7 67.6 42.8 25.3 35.8 21.9 40.9 28.4 33.1 26.0 101.5 26.8 13.5 54.7 22.0 18.3 33.3 21.6 28.5 51.6 31.8 14.2 40.3 31.1 59.8 29.9 32.6 73.0 59.3 19.6 79.7 37.0 73.4 16.6 39.8 23.5 22.2 32.9 58.2 49.2 7.1 6.6 37.5 27.4 35.2 31.7 30.5 22.2 66.8 PTPN12 "PTP-PEST, PTPG1" ENSG00000127947 "Protein tyrosine phosphatase non-receptor type 12" Q05209 7 77537295-77640069 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007097 Approved Approved "Plasma membrane,Cytosol" NA NA 770000 "Cluster 40: NK-cells - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 17: WM-115 - Nervous system development" "Cluster 51: Myeloid cells - Hemostasis" "Plasma membrane, Cytosol" "HPA007097: AB_1079689" "unprognostic (2.28e-1)" "prognostic unfavorable (1.15e-4)" "unprognostic (1.35e-1)" "unprognostic (3.35e-2)" "unprognostic (1.40e-3)" "unprognostic (4.48e-3)" "prognostic unfavorable (8.78e-4)" "unprognostic (1.29e-1)" "unprognostic (5.83e-2)" "unprognostic (2.64e-1)" "prognostic unfavorable (2.01e-4)" "unprognostic (1.09e-1)" "prognostic unfavorable (7.27e-6)" "unprognostic (4.99e-2)" "unprognostic (2.97e-1)" "unprognostic (1.81e-1)" "unprognostic (3.21e-1)" 60.5 30.1 24.2 43.9 26.6 69.9 50.3 29.2 31.6 40.9 25.9 48.9 18.9 38.6 18.6 38.5 39.6 40.2 39.0 25.1 27.3 36.1 30.9 65.0 27.5 28.5 27.8 34.6 20.1 21.0 21.9 74.7 30.5 26.4 27.7 30.9 23.8 33.2 24.6 36.9 29.7 40.2 26.7 52.7 27.1 30.1 32.7 33.9 31.0 44.5 27.5 46.7 39.6 30.2 72.4 43.5 100.6 51.8 69.1 71.7 54.2 73.3 93.0 56.6 80.0 21.6 109.9 8.6 23.2 86.3 123.6 50.2 34.2 73.4 113.3 21.2 19.2 44.9 44.2 88.4 67.7 25.8 28.8 59.0 80.3 123.2 157.6 101.0 121.6 2.1 54.9 12.2 182.6 49.4 3.6 71.9 81.7 97.6 49.2 15.1 80.6 4.5 97.6 38.5 12.5 66.6 90.4 81.5 73.4 172.2 39.5 93.9 89.3 121.4 73.1 45.0 141.3 12.6 7.4 22.2 71.6 65.9 215.7 3.6 4.1 6.8 3.1 2.8 1.3 2.3 1.1 2.6 3.8 1.0 0.6 3.3 9.5 13.3 5.3 0.3 1.6 2.7 24.2 26.6 29.2 31.6 25.1 27.3 28.5 27.8 30.5 26.7 32.7 30.2 139.3 70.5 56.2 30.0 18.2 68.8 60.0 55.9 23.9 16.7 40.9 26.3 41.3 28.6 46.4 20.2 8.4 40.0 89.0 31.2 3.9 42.1 3.5 43.9 62.4 114.4 12.1 16.6 65.8 39.6 58.7 54.6 21.4 87.2 14.5 21.7 119.2 24.6 50.1 35.3 58.0 21.7 28.5 82.0 121.3 6.7 46.6 96.1 35.6 93.7 54.9 66.9 163.7 70.4 67.3 75.0 21.4 47.0 17.6 62.0 10.9 19.2 23.2 15.2 65.7 127.9 66.8 51.2 71.4 29.8 101.4 72.1 27.3 24.4 23.3 104.8 PTPN13 "PTP-BAS, PTP-BL, PTP1E, PTPL1" ENSG00000163629 "Protein tyrosine phosphatase non-receptor type 13" Q12923 4 86594315-86815171 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "retina: 124.3" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 223.1;Astrocytes: 165.2;Oligodendrocytes: 200.2;Rod photoreceptor cells: 179.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "non-classical monocyte: 2.0" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "AF22: 117.6;RT4: 57.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002213, HPA063119" Approved Supported "Nucleoplasm,Nucleoli fibrillar center,Cytosol" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 12: NES - Nervous system development" "Cluster 46: Photoreceptor cells - Phototransduction" Nucleoplasm "Nucleoli fibrillar center, Cytosol" "CAB002213: AB_564089, HPA063119: " "unprognostic (5.36e-2)" "unprognostic (4.46e-1)" "unprognostic (1.11e-1)" "unprognostic (2.54e-3)" "unprognostic (4.02e-1)" "unprognostic (9.03e-3)" "unprognostic (4.43e-2)" "unprognostic (4.38e-2)" "unprognostic (2.46e-1)" "unprognostic (7.05e-2)" "unprognostic (3.69e-2)" "unprognostic (1.46e-1)" "unprognostic (1.28e-3)" "unprognostic (3.95e-3)" "unprognostic (2.26e-1)" "unprognostic (2.66e-1)" "unprognostic (2.85e-2)" 14.0 6.7 9.9 3.0 16.6 0.3 11.7 8.1 10.8 18.8 22.4 5.2 0.8 13.1 25.5 22.2 13.0 7.7 6.1 14.2 10.6 26.6 1.4 22.9 5.2 16.7 13.1 28.7 4.9 17.5 16.8 3.3 10.5 11.0 2.4 124.3 6.6 10.6 1.0 55.9 2.6 7.9 8.2 4.0 4.1 15.8 13.8 7.6 20.8 5.0 11.5 20.7 22.7 20.4 13.8 6.8 117.6 11.5 48.2 41.9 0.0 25.0 51.0 9.4 11.7 0.1 6.8 0.0 5.3 28.0 3.3 44.4 20.6 37.9 18.0 0.3 15.1 11.4 14.6 0.0 5.9 20.5 0.1 27.2 11.8 6.8 22.4 19.7 0.0 0.0 0.0 19.2 0.0 6.2 1.8 7.4 26.5 0.0 5.1 4.1 0.0 0.0 35.6 57.2 6.8 9.8 7.4 16.4 13.3 18.8 9.6 0.7 0.0 9.1 6.9 0.2 3.3 19.8 0.0 0.0 9.5 0.0 4.0 0.0 0.1 0.0 0.1 1.3 0.9 0.0 0.8 0.1 0.2 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 9.9 16.6 8.1 10.8 14.2 10.6 16.7 13.1 10.5 8.2 13.8 20.4 5.3 48.1 223.1 165.2 0.6 109.4 25.6 26.3 79.1 11.6 11.2 8.9 1.8 11.5 52.0 47.8 91.8 0.2 0.3 0.1 3.9 5.0 23.2 16.9 49.4 3.7 4.8 0.8 67.0 3.7 0.1 28.8 4.1 7.7 5.1 7.5 3.6 0.1 0.3 1.7 39.3 1.1 8.2 1.4 10.6 20.8 45.7 4.5 19.6 51.5 0.5 20.3 0.0 75.4 200.2 6.2 2.7 32.7 3.0 16.0 0.1 10.9 27.3 179.0 13.1 10.1 20.8 25.4 20.5 97.8 99.4 0.3 6.6 14.0 0.7 52.5 PTPN14 PEZ ENSG00000152104 "Protein tyrosine phosphatase non-receptor type 14" Q15678 1 214348700-214552449 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Microglial cells: 91.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB011469, HPA053864, CAB069441" Uncertain Supported Nucleoplasm NA NA "Cluster 59: Non-specific - Translation" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Nucleoplasm "CAB011469: AB_299202, CAB069441: , HPA053864: AB_2682281" "unprognostic (1.54e-1)" "unprognostic (8.19e-2)" "unprognostic (5.42e-5)" "unprognostic (1.42e-1)" "unprognostic (2.91e-1)" "unprognostic (5.97e-2)" "unprognostic (1.26e-1)" "unprognostic (1.58e-1)" "unprognostic (2.84e-1)" "unprognostic (1.31e-1)" "prognostic unfavorable (2.29e-4)" "unprognostic (7.43e-2)" "unprognostic (8.34e-3)" "prognostic unfavorable (5.16e-4)" "unprognostic (1.16e-1)" "unprognostic (2.21e-1)" "unprognostic (4.81e-3)" 7.5 8.0 3.7 1.8 1.5 0.2 10.6 1.5 3.7 5.2 13.4 7.6 0.9 8.2 2.5 6.0 7.3 3.3 6.0 3.3 0.8 8.2 0.7 4.6 1.3 2.4 2.4 6.6 4.3 3.3 1.8 7.8 2.1 6.7 2.3 0.6 6.5 6.6 19.8 16.2 2.8 7.9 1.4 3.5 4.5 3.9 4.2 2.1 5.3 10.2 1.8 5.6 5.6 1.9 21.1 9.2 7.2 10.6 12.3 20.9 21.6 23.2 21.3 17.3 14.4 18.8 10.7 0.1 25.3 53.6 10.0 18.1 10.0 25.7 29.0 0.2 7.7 1.9 26.6 3.5 22.2 0.2 1.0 15.6 26.1 30.0 47.4 28.1 33.8 0.6 0.1 0.2 41.8 2.3 0.2 0.2 16.2 3.7 9.9 0.3 36.3 0.1 30.6 10.5 0.1 1.7 28.7 18.4 11.6 25.1 18.4 0.7 61.4 40.3 15.9 14.6 33.3 1.2 0.1 0.2 21.6 0.3 34.6 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 3.7 1.5 1.5 3.7 3.3 0.8 2.4 2.4 2.1 1.4 4.2 1.9 60.3 73.7 12.6 47.3 1.3 56.5 32.1 39.4 45.5 0.6 20.3 29.8 20.5 14.3 32.7 29.5 0.0 38.8 1.3 1.0 7.9 12.9 8.8 42.5 25.9 53.5 3.5 0.0 47.9 11.0 14.2 20.8 9.2 55.2 1.3 13.5 40.0 0.9 4.5 0.0 6.0 4.1 4.1 1.5 7.7 4.4 26.1 2.4 10.6 91.8 0.3 3.9 3.1 39.2 2.1 31.2 0.3 29.3 1.6 30.6 0.3 14.4 18.5 1.3 19.7 38.0 20.1 1.2 10.6 18.3 36.1 24.2 3.7 46.3 2.9 28.9 PTPN18 BDP1 ENSG00000072135 "Protein tyrosine phosphatase non-receptor type 18" Q99952 2 130356045-130375405 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Macrophages: 143.4;NK-cells: 148.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RPMI-8226: 63.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB012174, HPA053367" Uncertain Approved "Intermediate filaments" NA NA 270000 "Cluster 51: Monocytes - Innate immune response" "Cluster 64: Macrophages - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 51: Myeloid cells - Hemostasis" "Intermediate filaments" "CAB012174: AB_2173224, HPA053367: AB_2732579" "unprognostic (3.11e-3)" "unprognostic (2.89e-3)" "unprognostic (1.67e-3)" "unprognostic (1.73e-3)" "unprognostic (5.81e-3)" "unprognostic (3.08e-3)" "unprognostic (2.49e-2)" "unprognostic (1.28e-2)" "unprognostic (4.65e-1)" "unprognostic (2.10e-2)" "unprognostic (7.33e-2)" "unprognostic (5.65e-2)" "unprognostic (4.52e-2)" "unprognostic (1.00e-2)" "unprognostic (3.60e-1)" "unprognostic (1.05e-1)" "unprognostic (5.85e-3)" 22.3 12.3 19.6 23.2 19.4 28.2 21.5 21.7 21.4 21.2 18.4 35.3 21.7 15.7 6.1 17.8 19.6 14.8 15.3 18.8 19.1 25.4 37.8 22.0 42.7 21.0 19.6 12.5 34.6 9.5 19.0 12.2 20.1 33.3 24.7 6.4 31.9 13.2 7.5 12.7 39.4 13.3 18.7 63.8 27.0 4.6 20.0 11.1 20.0 7.5 48.6 18.8 18.9 19.6 12.4 8.3 3.2 16.2 19.7 13.5 32.9 6.2 5.6 7.9 8.8 16.4 18.5 46.4 6.2 15.2 3.7 13.8 14.3 14.1 7.6 21.1 8.0 16.9 9.8 19.5 10.2 16.6 44.5 16.0 11.4 8.7 12.0 1.7 15.2 10.1 16.1 34.2 15.4 24.3 3.1 28.4 3.3 26.6 8.6 28.4 9.5 63.0 15.9 7.5 20.6 5.4 10.9 38.6 18.7 3.1 13.2 24.1 14.4 11.2 12.6 6.2 5.9 5.6 1.6 44.5 17.1 14.9 12.4 8.4 7.8 6.7 6.4 11.2 4.0 7.3 4.2 6.1 6.9 5.1 2.6 5.1 4.8 3.1 19.4 7.5 6.0 10.7 19.6 19.4 21.7 21.4 18.8 19.1 21.0 19.6 20.1 18.7 20.0 19.6 37.2 28.9 23.9 12.1 43.6 6.5 28.8 15.9 12.0 13.4 52.0 53.5 9.0 18.6 17.5 36.8 4.2 15.6 85.6 75.9 54.8 19.0 0.9 20.6 14.0 30.7 48.6 32.4 18.2 45.4 30.5 16.3 65.2 24.0 35.5 12.2 25.7 21.1 92.4 10.1 18.6 52.5 30.5 113.6 35.9 1.6 19.0 143.4 33.8 35.6 65.2 18.4 148.3 5.5 6.1 29.0 66.9 11.3 23.5 37.9 41.3 37.3 20.5 11.6 19.7 15.1 21.5 2.6 6.0 19.4 5.8 11.5 39.3 16.2 47.5 28.9 PTPN2 "PTPT, TC-PTP, TCELLPTP, TCPTP" ENSG00000175354 "Protein tyrosine phosphatase non-receptor type 2" P17706 18 12785478-12929643 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 99.8" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015004, HPA046176" Enhanced Supported Nucleoplasm NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 21: OE19 - Mitochondria" "Cluster 22: Epithelial cell types - Mixed function" Nucleoplasm "HPA015004: AB_2669131, HPA046176: AB_2679569" "unprognostic (5.83e-3)" "unprognostic (8.50e-2)" "unprognostic (5.85e-2)" "unprognostic (7.21e-3)" "unprognostic (8.94e-3)" "unprognostic (2.31e-1)" "unprognostic (1.12e-1)" "unprognostic (1.68e-1)" "unprognostic (2.37e-3)" "prognostic favorable (1.37e-4)" "unprognostic (1.06e-2)" "unprognostic (1.75e-2)" "prognostic unfavorable (1.20e-8)" "unprognostic (3.19e-1)" "unprognostic (6.84e-3)" "unprognostic (2.17e-1)" "unprognostic (4.61e-3)" 23.4 15.2 10.0 32.8 10.8 57.2 23.7 21.0 17.1 19.9 15.6 22.2 18.9 16.0 20.4 20.0 17.4 22.4 14.7 11.0 10.4 17.3 25.8 26.3 44.4 12.3 10.4 26.8 33.1 14.1 18.3 19.5 11.8 17.6 24.1 20.2 29.4 13.5 16.7 21.0 19.5 16.9 10.7 28.5 18.0 13.6 10.0 99.8 17.5 11.9 43.5 37.2 19.9 14.3 34.8 20.7 23.7 7.9 26.5 47.4 23.0 22.7 50.2 47.5 42.2 45.4 48.8 54.3 37.2 23.6 53.2 20.4 39.0 62.2 62.1 21.2 23.5 38.4 17.7 47.6 36.4 91.1 35.1 40.2 57.6 43.3 85.1 29.2 24.6 58.1 37.9 71.6 38.6 39.9 91.3 74.5 28.5 141.7 24.0 30.4 37.3 61.9 40.2 54.6 42.3 22.0 46.0 26.7 41.8 25.1 22.4 51.5 18.8 59.8 58.0 45.1 49.8 22.6 24.5 77.8 28.3 49.3 25.7 23.7 52.6 39.2 37.0 47.7 50.4 54.4 43.7 41.4 62.5 39.5 31.6 34.9 19.0 64.1 46.7 53.0 57.3 40.7 10.0 10.8 21.0 17.1 11.0 10.4 12.3 10.4 11.8 10.7 10.0 14.3 25.8 35.3 77.0 38.5 82.4 59.9 106.0 88.0 61.5 44.1 37.0 50.5 15.0 47.1 84.4 14.7 104.3 54.1 130.4 32.2 13.7 55.1 24.3 51.0 44.8 32.0 32.3 40.8 81.1 68.8 52.5 38.1 24.5 78.7 56.4 53.1 20.3 27.9 51.3 15.2 60.5 35.0 69.2 99.2 92.5 23.2 29.2 93.4 23.2 44.0 137.0 17.6 128.8 22.6 55.0 40.0 45.1 25.6 120.2 126.4 29.9 23.1 55.4 84.5 19.7 35.4 33.8 23.3 61.3 40.0 50.2 81.1 84.2 65.2 39.5 152.4 PTPN21 "PTPD1, PTPRL10" ENSG00000070778 "Protein tyrosine phosphatase non-receptor type 21" Q16825 14 88465778-88555007 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 57.7;Syncytiotrophoblasts: 101.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "RH-30: 35.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011468, HPA073999" Approved Approved "Golgi apparatus,Cytosol" NA NA "Cluster 61: Skin - Cornification" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Cytosol "Golgi apparatus" "CAB011468: AB_442979, HPA073999: AB_2732247" "unprognostic (2.18e-1)" "unprognostic (4.21e-2)" "unprognostic (7.60e-2)" "unprognostic (3.09e-2)" "unprognostic (4.60e-2)" "unprognostic (5.71e-2)" "unprognostic (6.55e-2)" "unprognostic (5.19e-3)" "unprognostic (6.62e-2)" "unprognostic (1.02e-2)" "unprognostic (8.71e-3)" "unprognostic (3.04e-3)" "prognostic favorable (3.16e-9)" "unprognostic (6.52e-2)" "unprognostic (2.69e-1)" "unprognostic (2.56e-1)" "unprognostic (7.67e-2)" 10.0 5.4 6.7 4.1 7.2 0.0 9.2 6.4 6.6 11.5 10.1 11.9 6.0 12.0 5.9 10.3 10.1 8.7 21.3 6.2 8.0 7.8 7.7 17.9 2.1 9.7 7.8 17.5 9.4 8.3 4.5 10.3 7.2 9.3 7.6 9.1 7.4 9.5 11.8 29.0 8.2 10.4 7.9 4.0 9.0 20.2 7.4 1.1 18.7 9.8 1.9 10.1 9.8 7.4 5.8 4.6 11.8 4.6 12.3 10.6 12.1 15.2 11.6 8.8 12.2 8.1 10.2 0.0 3.6 19.6 7.9 5.4 1.7 5.4 12.9 0.3 2.7 0.0 5.6 3.4 13.6 0.1 0.2 7.1 10.4 7.4 8.8 11.4 7.2 0.0 1.8 0.2 22.9 4.7 0.0 0.3 3.5 6.2 8.7 0.1 35.3 0.1 7.7 4.1 0.8 13.6 8.7 21.6 5.2 10.0 10.7 2.3 14.5 16.3 12.8 6.7 10.6 0.5 1.9 0.0 6.0 0.2 6.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.7 7.2 6.4 6.6 6.2 8.0 9.7 7.8 7.2 7.9 7.4 7.4 7.2 57.7 6.0 14.4 0.0 10.5 6.3 4.0 4.0 7.2 7.1 5.8 34.9 5.7 7.1 7.3 35.5 10.3 0.1 18.1 0.0 5.0 19.1 10.2 11.4 6.0 4.8 8.0 12.8 8.4 5.4 12.0 7.1 7.1 2.5 9.2 6.1 9.7 1.9 1.7 14.4 15.0 8.2 1.3 3.9 5.3 17.1 0.4 0.0 13.1 0.0 4.7 1.0 28.1 20.3 10.7 6.1 27.1 0.0 8.8 6.7 3.5 10.3 9.4 0.0 12.7 10.5 20.2 6.6 3.5 11.9 101.9 0.6 7.4 6.2 4.7 PTPN22 "Lyp, Lyp1, Lyp2, PTPN8" ENSG00000134242 "Protein tyrosine phosphatase non-receptor type 22" Q9Y2R2 1 113813811-113871753 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, Immunity" "Hydrolase, Protein phosphatase" "Diabetes mellitus, Disease variant, Systemic lupus erythematosus" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 38.0;lymphoid tissue: 20.3" "Group enriched" "Detected in many" 4 "B-cells: 67.4;dendritic cells: 176.0;NK-cells: 108.1;Plasma cells: 79.6;T-cells: 151.2" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Daudi: 69.3;HL-60: 27.7;U-266/70: 29.2;U-698: 37.5;U-937: 28.4" "Region enriched" "Detected in single" 11 "cerebellum: 5.3" "Not detected" "Not detected" "HPA004912, CAB012209, HPA013350" Approved Uncertain "Nucleoplasm,Vesicles,Plasma membrane" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" Nucleoplasm "Vesicles, Plasma membrane" "CAB012209: , HPA004912: AB_10602069, HPA013350: AB_10601570" "unprognostic (2.25e-2)" "unprognostic (5.31e-3)" "unprognostic (3.48e-1)" "unprognostic (3.33e-4)" "unprognostic (9.14e-2)" "unprognostic (2.47e-3)" "unprognostic (9.60e-2)" "unprognostic (8.14e-2)" "unprognostic (3.71e-1)" "unprognostic (1.82e-1)" "unprognostic (1.62e-1)" "unprognostic (3.02e-1)" "unprognostic (2.75e-6)" "unprognostic (3.19e-1)" "unprognostic (1.10e-1)" "unprognostic (1.61e-1)" "unprognostic (3.22e-2)" 2.0 1.5 0.2 11.5 0.2 38.0 2.3 0.4 0.5 1.8 0.6 4.0 6.4 1.0 1.1 1.7 0.9 4.8 0.6 0.1 0.2 0.6 2.0 7.5 20.3 0.5 0.2 0.6 1.3 0.3 0.3 0.8 0.4 1.0 4.3 0.4 1.3 0.6 0.3 0.9 8.6 1.6 0.2 13.2 5.2 1.4 0.6 20.0 0.7 0.2 13.5 4.2 0.9 0.8 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.9 0.4 0.0 0.7 0.0 0.4 69.3 0.1 0.2 0.0 0.0 0.0 0.1 0.5 6.5 0.0 10.0 0.0 0.0 0.2 27.7 21.1 5.7 0.0 2.8 0.2 5.1 10.6 17.2 0.1 15.7 10.3 0.2 20.1 15.7 0.0 0.1 0.0 1.2 6.7 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 10.0 5.0 16.0 0.3 0.4 0.5 29.2 6.6 37.5 11.1 28.4 0.1 15.8 4.8 25.0 17.0 1.3 20.1 9.9 8.4 13.6 8.7 7.4 5.0 12.1 2.4 11.0 0.6 5.2 14.5 7.3 0.2 0.2 0.4 0.5 0.1 0.2 0.5 0.2 0.4 0.2 0.6 0.8 2.2 0.0 6.5 0.7 67.4 2.5 0.2 0.0 1.2 0.7 2.2 2.4 0.8 0.0 0.2 1.8 2.1 0.1 176.0 2.2 0.0 0.1 0.4 0.7 0.5 1.7 0.0 16.6 3.2 0.6 0.3 2.2 12.8 1.0 27.8 0.0 0.4 0.5 7.1 0.0 2.5 1.2 0.0 17.3 26.8 1.0 0.0 26.4 3.6 2.8 14.4 0.0 108.1 0.0 1.7 0.5 0.8 0.0 79.6 0.3 4.3 0.1 2.2 0.5 13.1 0.6 1.4 0.4 0.6 0.3 2.7 0.1 151.2 0.0 2.2 0.3 PTPN23 "DKFZP564F0923, HD-PTP, KIAA1471" ENSG00000076201 "Protein tyrosine phosphatase non-receptor type 23" Q9H3S7 3 47381011-47413435 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cilium biogenesis/degradation, Protein transport, Transport" "Hydrolase, Protein phosphatase" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016845 Approved Supported "Nucleoplasm,Nuclear bodies,Vesicles" Yes No "Cluster 10: Basophils - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 15: RT4 - Unknown function" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Nuclear bodies" Vesicles "HPA016845: AB_1855926" "unprognostic (1.17e-3)" "unprognostic (8.68e-2)" "unprognostic (2.56e-1)" "unprognostic (1.26e-1)" "unprognostic (1.63e-1)" "unprognostic (6.24e-2)" "unprognostic (1.07e-3)" "unprognostic (2.07e-2)" "unprognostic (9.55e-2)" "unprognostic (7.12e-2)" "unprognostic (5.67e-2)" "unprognostic (4.34e-2)" "prognostic favorable (1.82e-4)" "unprognostic (3.05e-2)" "unprognostic (4.40e-1)" "unprognostic (9.53e-2)" "unprognostic (4.68e-2)" 18.5 19.1 6.2 12.6 9.2 14.7 17.4 5.8 10.5 23.3 5.1 16.3 14.3 20.9 7.5 19.0 19.2 8.4 13.2 7.1 7.2 17.5 14.0 18.7 9.1 8.8 7.2 23.5 20.2 23.5 30.9 11.6 8.5 18.7 6.5 8.5 20.0 11.4 30.0 26.4 18.4 8.8 5.5 20.0 16.1 15.6 7.7 8.0 27.1 8.9 7.3 18.5 20.4 14.4 21.5 29.9 16.4 21.4 21.0 16.0 15.8 19.2 18.9 17.5 14.8 25.0 20.7 15.1 17.2 21.9 31.2 19.0 14.3 20.8 8.5 14.3 15.1 21.0 22.2 24.0 23.0 12.3 27.5 21.4 20.9 22.9 23.2 12.4 21.7 12.5 15.9 20.3 19.0 30.2 11.5 10.4 17.5 14.9 20.1 7.2 7.9 18.5 13.2 40.9 8.6 20.6 17.1 35.6 13.6 9.8 20.3 12.0 22.4 26.7 22.2 37.7 27.5 28.8 20.4 8.7 29.0 11.6 19.5 0.8 0.2 0.0 0.1 0.1 0.0 0.2 0.1 0.2 0.0 0.1 0.1 0.1 0.2 0.2 0.0 0.2 0.3 0.3 6.2 9.2 5.8 10.5 7.1 7.2 8.8 7.2 8.5 5.5 7.7 14.4 11.1 9.6 7.0 17.0 8.2 8.0 5.2 6.9 13.6 11.7 9.5 8.0 8.7 8.6 9.5 5.5 14.6 10.6 11.0 15.7 1.9 10.5 2.1 10.3 13.7 12.4 7.3 2.5 9.8 8.9 7.9 9.1 26.5 21.1 2.5 14.9 11.4 12.7 13.9 16.8 12.0 16.3 20.3 10.4 5.5 3.1 19.3 9.5 12.4 7.5 8.7 8.8 6.2 9.5 14.3 13.5 10.4 13.5 15.4 9.3 14.6 9.4 12.6 14.2 6.6 10.2 8.8 13.6 13.3 13.2 10.9 9.3 8.9 9.4 12.8 8.2 PTPN3 PTPH1 ENSG00000070159 "Protein tyrosine phosphatase non-receptor type 3" P26045 9 109375466-109498313 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 63.5" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 48.6" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in many" "thalamus: 26.7" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "OE19: 29.4;RPTEC TERT1: 34.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038343, HPA046728" Approved NA NA "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 44: Endometrium - Transcription" "HPA038343: AB_10671741, HPA046728: AB_2679776" "prognostic unfavorable (6.71e-4)" "unprognostic (3.48e-1)" "unprognostic (3.64e-2)" "prognostic favorable (1.52e-4)" "unprognostic (2.32e-2)" "unprognostic (1.27e-1)" "unprognostic (2.34e-1)" "unprognostic (4.86e-2)" "unprognostic (3.71e-2)" "unprognostic (5.38e-2)" "unprognostic (6.37e-2)" "unprognostic (3.57e-2)" "prognostic favorable (1.22e-15)" "unprognostic (1.64e-2)" "unprognostic (2.64e-1)" "unprognostic (1.11e-1)" "unprognostic (8.21e-2)" 4.0 2.2 7.1 1.7 1.0 0.1 7.5 0.0 2.6 6.6 8.5 9.5 12.4 2.2 17.7 13.2 10.1 2.7 21.1 3.2 5.2 23.0 29.5 5.7 1.1 0.3 14.7 0.6 14.8 10.7 2.9 7.3 1.6 5.9 10.1 2.5 8.5 5.1 63.5 30.1 12.9 1.4 0.4 0.3 9.7 3.2 26.7 3.6 10.1 46.9 4.4 4.2 7.2 0.4 11.1 13.5 0.5 3.5 0.0 0.0 21.1 2.3 0.0 2.9 3.2 7.2 17.7 0.0 2.4 0.1 7.3 25.8 3.7 15.2 2.9 6.2 8.2 0.0 6.2 7.5 0.1 0.0 0.1 0.2 16.0 3.6 7.7 1.2 0.0 4.5 0.0 0.1 0.2 14.0 19.3 3.3 1.6 29.4 10.0 0.1 4.4 0.3 34.0 21.1 8.6 1.8 5.9 21.8 0.0 7.1 12.5 1.8 0.1 1.0 8.2 1.4 0.0 10.4 18.2 0.0 11.2 0.0 7.7 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 7.1 1.0 0.0 2.6 3.2 5.2 0.3 14.7 1.6 0.4 26.7 0.4 0.4 16.0 28.4 0.7 0.5 11.9 25.9 19.3 4.0 13.4 7.8 8.6 48.6 24.3 24.7 31.3 0.0 23.6 0.1 30.0 17.6 14.5 21.5 27.6 3.1 3.3 13.1 0.0 16.1 19.2 23.7 1.8 15.8 38.4 1.3 0.9 4.6 36.3 2.6 0.0 5.2 18.7 8.2 0.0 1.8 18.5 1.2 0.8 3.6 1.0 0.7 0.3 1.0 0.5 0.6 29.1 24.0 1.9 0.2 26.1 27.9 19.2 28.4 2.2 6.6 3.2 6.0 1.6 10.4 7.0 20.6 10.8 0.8 0.4 18.4 29.0 PTPN4 PTPMEG ENSG00000088179 "Protein tyrosine phosphatase non-receptor type 4" P29074 2 119759922-119984899 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 37.3" "Cell type enhanced" "Detected in many" "Excitatory neurons: 224.3;Horizontal cells: 161.5;Inhibitory neurons: 187.5;NK-cells: 247.2;Oligodendrocyte precursor cells: 200.6" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "cerebellum: 37.3" "Group enriched" "Detected in many" 4 "gdT-cell: 35.0;MAIT T-cell: 28.1;memory CD4 T-cell: 16.9;memory CD8 T-cell: 27.9;naive CD8 T-cell: 19.2;NK-cell: 24.4;T-reg: 11.0" "Group enriched" "Detected in many" 16 "NK-cells: 24.4;T-cells: 35.0" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019351 Uncertain Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 44: HDLM-2 - Immune response" "Cluster 63: NK-cells & T-cells - Immune response" Nucleoplasm "Plasma membrane, Cytosol" "HPA019351: AB_1855928" "unprognostic (1.45e-1)" "unprognostic (1.22e-1)" "unprognostic (1.07e-1)" "unprognostic (7.63e-2)" "unprognostic (9.00e-2)" "unprognostic (9.57e-2)" "unprognostic (2.34e-1)" "prognostic favorable (5.16e-4)" "unprognostic (3.31e-2)" "unprognostic (3.34e-3)" "unprognostic (3.13e-1)" "unprognostic (1.10e-1)" "unprognostic (3.34e-2)" "unprognostic (1.74e-1)" "unprognostic (1.87e-1)" "unprognostic (4.08e-2)" "unprognostic (1.81e-1)" 4.5 3.8 5.9 3.6 5.0 5.1 4.7 37.3 10.1 5.7 0.0 3.4 5.1 4.1 4.2 4.1 5.5 3.7 5.7 5.2 2.7 7.4 4.2 5.2 5.4 0.1 9.6 5.2 2.8 6.3 3.5 2.5 1.4 3.5 2.4 12.1 4.1 2.5 8.0 3.0 2.8 2.8 0.0 5.9 5.7 4.9 12.6 8.1 14.0 12.8 4.2 3.2 2.6 5.9 7.4 4.3 5.0 7.3 4.8 5.0 9.1 3.2 9.3 1.8 4.9 6.2 10.9 4.1 7.6 3.5 5.2 5.3 4.4 5.1 4.8 12.6 3.6 3.7 3.5 6.1 3.2 3.9 2.6 4.5 9.6 8.5 3.7 6.0 8.2 4.8 5.7 4.8 5.0 5.0 5.2 4.4 7.3 4.0 6.9 3.4 9.6 6.9 6.7 10.0 6.8 8.5 4.2 5.8 4.0 4.0 2.8 2.4 10.7 0.0 6.1 1.9 4.0 8.9 13.7 6.6 4.7 0.1 3.0 0.3 0.2 1.8 35.0 0.5 28.1 0.6 16.9 27.9 0.5 0.6 5.2 19.2 0.6 24.4 0.7 0.3 11.0 10.4 5.9 5.0 37.3 10.1 5.2 2.7 0.1 9.6 1.4 0.0 12.6 5.9 20.5 3.2 14.6 128.9 24.4 8.2 15.5 8.5 27.3 55.7 13.9 11.2 17.9 10.0 8.3 16.5 104.3 10.5 95.5 7.3 7.9 8.0 5.4 18.2 15.7 15.0 9.1 35.4 224.3 7.3 11.8 11.3 16.8 15.8 11.4 47.9 15.0 11.0 4.0 161.5 187.5 9.9 12.2 8.6 7.6 8.8 17.4 9.0 8.8 38.4 11.8 24.9 247.2 200.6 113.6 6.3 9.6 14.3 30.1 12.7 10.6 13.6 8.8 79.8 0.0 25.5 9.0 31.4 26.4 12.8 6.7 3.7 79.4 23.3 11.5 9.5 PTPN5 "PTPSTEP, STEP, STEP61" ENSG00000110786 "Protein tyrosine phosphatase non-receptor type 5" P54829 11 18727928-18792721 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 13 "brain: 161.0" "Group enriched" "Detected in some" 4 "Excitatory neurons: 59.0;Inhibitory neurons: 51.9" "Group enriched" "Detected in some" 6 "glioma: 1.6;testis cancer: 2.0" "Region enhanced" "Detected in many" "basal ganglia: 161.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HMC-1: 1.1;NTERA-2: 1.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031014, HPA072091" Supported Approved "Endoplasmic reticulum" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 5: NTERA-2 - Transcription" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Endoplasmic reticulum" "HPA031014: AB_10669550, HPA072091: AB_2686487" "unprognostic (1.23e-1)" "unprognostic (2.91e-2)" "unprognostic (8.93e-3)" "unprognostic (1.09e-2)" "unprognostic (3.27e-2)" "unprognostic (2.13e-2)" "unprognostic (5.83e-3)" "unprognostic (3.59e-1)" "unprognostic (4.91e-2)" "unprognostic (2.59e-1)" "unprognostic (2.00e-1)" "unprognostic (3.58e-1)" "unprognostic (8.44e-4)" "unprognostic (4.21e-3)" "unprognostic (3.90e-2)" "unprognostic (9.39e-2)" "unprognostic (8.49e-2)" 1.5 0.5 37.2 0.2 161.0 0.1 1.1 0.0 55.2 0.7 0.0 1.0 0.1 0.8 0.0 0.5 1.1 0.3 11.9 32.1 25.5 1.7 0.0 1.5 0.1 11.3 6.4 2.1 0.4 0.2 2.1 0.0 6.7 1.0 0.3 2.0 1.2 0.6 0.7 0.6 0.6 0.4 4.7 0.4 0.9 2.9 19.9 0.0 0.7 3.3 0.0 1.0 1.1 29.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 37.2 161.0 0.0 55.2 32.1 25.5 11.3 6.4 6.7 4.7 19.9 29.5 0.1 0.0 0.0 4.2 0.0 0.1 0.0 0.0 0.0 1.8 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.1 0.0 0.2 6.9 0.0 0.0 59.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 51.9 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 6.5 0.0 0.3 0.0 12.5 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.7 0.0 2.7 0.1 0.0 0.0 0.0 0.2 0.0 0.0 PTPN6 "HCP, HCPH, PTP-1C, SHP-1, SHP1" ENSG00000111679 "Protein tyrosine phosphatase non-receptor type 6" P29350 12 6946468-6961316 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 131.8;lymphoid tissue: 153.5" "Cell type enhanced" "Detected in many" "B-cells: 214.6;granulocytes: 137.3;Hofbauer cells: 191.6;Kupffer cells: 146.5;Langerhans cells: 118.2;Macrophages: 152.1;NK-cells: 154.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HEL: 170.9;HL-60: 154.3;HMC-1: 648.7;THP-1: 259.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001466, CAB004572, CAB072845" Enhanced Supported Nucleoplasm,Nucleoli NA NA 6000000 "Cluster 51: Monocytes - Innate immune response" "Cluster 16: Immune cells - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 57: B-cells - Immune response" Nucleoplasm Nucleoli "CAB004572: AB_628251, CAB072845: , HPA001466: AB_1855930" "unprognostic (4.28e-3)" "prognostic favorable (1.87e-4)" "prognostic unfavorable (5.42e-4)" "prognostic favorable (6.65e-4)" "unprognostic (6.54e-2)" "unprognostic (7.92e-2)" "unprognostic (2.36e-1)" "unprognostic (1.44e-2)" "unprognostic (6.93e-3)" "unprognostic (3.57e-1)" "unprognostic (1.41e-2)" "unprognostic (2.61e-1)" "unprognostic (1.60e-3)" "unprognostic (1.98e-3)" "unprognostic (2.60e-2)" "unprognostic (5.91e-2)" "prognostic favorable (2.64e-8)" 14.4 15.6 3.7 102.5 3.9 131.8 11.0 4.3 4.2 11.1 6.0 21.9 30.4 6.2 10.2 12.8 13.9 20.3 4.9 3.6 5.2 12.2 19.3 49.7 153.5 7.0 4.6 2.9 11.9 13.7 10.0 19.8 6.3 11.7 21.3 0.7 17.0 9.0 2.0 18.8 42.0 12.3 5.9 128.0 28.0 3.1 6.3 71.3 12.6 4.5 127.3 27.0 7.5 10.6 16.4 30.8 0.2 0.1 0.1 0.0 28.5 0.0 0.0 0.0 0.0 16.5 36.0 11.9 8.4 0.0 0.0 18.3 0.3 21.6 0.0 7.3 6.5 170.9 3.4 13.9 0.0 154.3 648.7 0.1 15.4 0.0 6.5 0.0 0.0 60.0 0.3 1.3 0.0 34.5 55.4 92.2 8.3 38.0 5.1 50.4 0.2 86.5 16.7 30.2 2.7 0.0 5.2 24.9 0.2 20.9 7.7 259.8 0.4 0.0 0.2 0.1 0.2 0.4 0.2 5.5 0.4 66.3 0.5 676.7 368.3 1112.5 263.4 728.6 169.3 595.0 125.3 195.9 377.0 650.0 142.7 182.6 674.8 238.6 1117.7 98.7 146.8 789.3 3.7 3.9 4.3 4.2 3.6 5.2 7.0 4.6 6.3 5.9 6.3 10.6 10.5 6.4 13.8 0.7 214.6 9.1 8.2 18.8 29.6 0.0 8.6 10.0 2.1 11.5 15.3 5.5 0.0 25.6 77.7 16.0 15.6 15.8 50.4 12.1 1.5 7.5 24.7 22.9 0.9 15.4 18.3 3.0 25.0 11.8 137.3 10.9 8.9 11.6 191.6 0.0 0.9 13.2 18.3 146.5 118.2 10.5 0.9 152.1 14.2 3.7 99.7 0.5 154.5 2.0 0.1 12.6 16.9 0.0 53.5 3.9 22.8 14.3 17.2 0.5 6.6 1.6 4.0 0.3 1.3 14.6 8.7 18.5 86.2 24.5 15.6 7.8 PTPN7 "HEPTP, LC-PTP" ENSG00000143851 "Protein tyrosine phosphatase non-receptor type 7" P35236 1 202147013-202161588 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 39.7;lymphoid tissue: 31.1" "Cell type enhanced" "Detected in many" "B-cells: 46.8;dendritic cells: 112.7;granulocytes: 140.7;NK-cells: 99.9;Plasma cells: 63.9;T-cells: 127.2;Theca cells: 54.6" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "basal ganglia: 9.8" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in all" 5 "granulocytes: 24.9;NK-cells: 14.9;T-cells: 14.0" "Cell line enhanced" "Detected in some" "HEL: 54.1;HL-60: 118.6;HMC-1: 150.8;NB-4: 51.4;THP-1: 53.7;U-937: 84.0" "Region enriched" "Detected in single" 9 "basal ganglia: 6.1" "Region enriched" "Detected in many" 8 "basal ganglia: 13.3" "CAB009530, HPA019118" Approved Supported "Microtubules,Mitotic spindle,Cytosol" Yes NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 3: HMC-1 - Innate immune response" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "Microtubules, Mitotic spindle" "CAB009530: AB_2173845, HPA019118: AB_1855755" "unprognostic (4.19e-3)" "unprognostic (1.08e-3)" "unprognostic (3.09e-2)" "prognostic favorable (1.52e-4)" "unprognostic (2.91e-2)" "prognostic favorable (1.84e-4)" "unprognostic (3.01e-2)" "unprognostic (3.16e-2)" "unprognostic (1.43e-2)" "unprognostic (4.84e-2)" "unprognostic (1.14e-1)" "unprognostic (1.45e-1)" "prognostic unfavorable (2.42e-8)" "unprognostic (1.46e-1)" "unprognostic (4.51e-2)" "unprognostic (2.70e-1)" "unprognostic (2.39e-2)" 1.3 4.2 0.6 10.2 9.8 39.7 0.7 1.0 1.8 0.8 0.5 2.2 4.5 1.1 0.0 1.5 0.6 3.2 0.5 0.6 1.2 1.3 1.1 2.5 20.8 2.3 1.5 0.3 0.4 0.1 0.3 0.5 1.8 0.8 2.7 0.0 1.3 0.6 0.1 1.2 5.6 1.5 1.4 9.9 2.4 8.3 2.9 31.1 0.8 0.5 20.8 3.2 0.6 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 41.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 12.6 0.0 54.1 0.0 0.0 0.0 118.6 150.8 0.0 0.0 0.0 0.0 0.0 0.1 40.0 2.3 5.0 0.0 0.0 16.3 51.4 0.0 0.0 0.0 2.4 0.0 39.8 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.1 53.7 0.3 0.0 0.5 0.0 0.1 22.8 6.3 33.7 0.1 84.0 0.1 17.9 1.5 24.9 13.7 1.5 12.5 2.6 9.2 14.0 2.9 3.2 6.7 8.2 9.9 14.9 0.6 3.8 12.8 4.5 0.6 9.8 1.0 1.8 0.6 1.2 2.3 1.5 1.8 1.4 2.9 2.5 3.2 3.2 5.1 3.3 46.8 2.3 1.3 0.1 0.0 2.7 1.5 1.8 0.7 1.5 0.7 0.0 0.0 0.5 112.7 0.5 0.0 0.5 0.6 0.9 0.8 5.6 0.0 35.5 0.7 0.0 0.2 2.2 1.5 0.7 140.7 6.7 3.6 0.4 15.4 0.0 0.7 0.1 0.0 11.2 31.2 2.4 5.3 21.3 8.8 1.0 10.4 3.8 99.9 1.0 4.6 0.1 0.1 2.2 63.9 0.6 0.2 0.7 0.1 3.7 0.0 0.9 1.1 0.8 0.7 0.5 2.4 0.8 127.2 54.6 0.5 0.6 PTPN9 MEG2 ENSG00000169410 "Protein tyrosine phosphatase non-receptor type 9" P43378 15 75463251-75579315 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 63.0;Excitatory neurons: 66.1;Inhibitory neurons: 63.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041922 Approved Approved Vesicles NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 43: THP-1 - Innate immune response" "Cluster 50: Fibroblasts - ECM organization" Vesicles "HPA041922: AB_10795269" "unprognostic (9.58e-2)" "unprognostic (1.87e-1)" "unprognostic (1.28e-1)" "unprognostic (2.42e-1)" "unprognostic (1.54e-2)" "unprognostic (6.80e-2)" "unprognostic (7.38e-2)" "unprognostic (5.95e-2)" "unprognostic (3.93e-1)" "unprognostic (3.14e-1)" "unprognostic (9.25e-3)" "unprognostic (6.35e-2)" "prognostic favorable (2.49e-6)" "unprognostic (2.26e-1)" "unprognostic (1.05e-1)" "unprognostic (2.71e-1)" "unprognostic (2.39e-1)" 15.9 12.0 14.8 13.0 16.3 10.8 15.1 11.9 18.8 16.6 11.7 18.0 17.9 16.5 13.3 9.9 16.2 12.1 11.0 16.9 18.4 18.2 14.7 15.8 14.5 18.6 14.4 14.0 10.2 17.9 9.7 19.9 15.1 16.6 19.7 8.9 13.0 21.2 6.4 11.0 20.0 18.0 13.6 13.4 13.5 7.2 17.0 16.1 32.8 13.1 15.0 18.1 13.8 14.5 20.3 24.1 36.7 24.6 26.8 29.3 12.0 29.8 46.2 36.9 33.4 14.5 30.0 32.6 23.3 51.1 29.5 30.0 79.9 34.3 37.0 40.5 19.8 18.4 16.2 15.7 40.2 28.2 27.1 38.4 35.2 29.6 45.9 37.7 31.4 21.3 12.4 11.5 42.1 13.5 20.0 26.3 33.6 18.2 12.1 38.9 18.2 9.1 46.6 32.5 14.4 29.9 42.4 23.3 46.3 34.9 12.1 47.8 36.5 35.2 11.3 23.3 32.2 16.9 18.9 30.0 20.5 41.9 35.3 3.2 2.2 2.3 3.4 3.0 2.8 1.7 2.4 3.0 3.0 1.3 1.0 1.8 0.3 3.9 2.9 2.0 1.6 1.7 14.8 16.3 11.9 18.8 16.9 18.4 18.6 14.4 15.1 13.6 17.0 14.5 12.7 6.4 13.4 63.0 9.2 3.3 8.2 6.6 5.7 12.1 8.0 7.1 3.7 10.0 8.1 11.0 8.4 20.0 7.3 25.0 15.6 10.8 3.0 7.9 19.4 10.0 7.2 13.7 66.1 9.9 4.2 20.6 10.7 11.4 15.2 23.6 17.5 12.6 18.8 3.3 63.2 11.5 6.1 18.9 18.1 4.7 12.5 16.5 7.2 46.9 24.2 5.6 19.6 48.7 19.6 18.2 12.6 27.4 9.7 12.1 24.9 14.0 8.1 17.1 13.1 11.7 20.8 10.6 9.4 6.6 3.3 10.1 13.4 11.6 13.2 13.1 PTPRA "HLPR, HPTPA, LRP, PTPA, PTPRL2, RPTPA" ENSG00000132670 "Protein tyrosine phosphatase receptor type A" P18433 20 2864184-3039076 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029412, CAB034366, HPA069480" Approved Approved Nucleoplasm,Vesicles NA NA "Cluster 37: B-cells - Transcription" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" Vesicles Nucleoplasm "CAB034366: AB_2269058, HPA029412: AB_10602293, HPA069480: AB_2686141" "unprognostic (1.39e-1)" "unprognostic (2.05e-1)" "unprognostic (4.58e-2)" "unprognostic (2.39e-3)" "unprognostic (1.15e-1)" "unprognostic (1.62e-1)" "unprognostic (5.43e-3)" "unprognostic (5.34e-2)" "unprognostic (1.55e-1)" "unprognostic (3.24e-1)" "unprognostic (7.33e-2)" "unprognostic (1.16e-1)" "prognostic favorable (3.29e-6)" "unprognostic (1.25e-1)" "unprognostic (4.02e-1)" "unprognostic (1.60e-2)" "unprognostic (4.19e-1)" 48.8 36.6 83.9 31.9 89.3 39.6 47.4 84.2 96.1 56.4 59.5 41.6 31.0 53.0 36.7 46.1 52.7 43.7 29.5 87.7 83.5 44.2 28.6 45.4 38.9 74.7 81.9 55.8 31.2 81.9 44.8 60.8 78.3 46.3 40.6 61.5 36.3 41.9 16.9 45.8 32.7 52.4 76.3 39.4 34.5 43.4 92.6 59.6 65.5 30.7 44.3 46.6 38.9 81.1 74.0 44.2 124.7 38.4 134.4 243.3 26.5 54.1 105.1 65.5 79.6 53.1 99.5 48.1 41.6 73.1 66.1 77.2 51.0 77.4 73.4 74.7 32.7 68.5 18.3 68.0 48.1 69.5 31.1 109.8 78.2 54.4 56.8 80.3 92.0 67.7 69.9 59.7 65.8 30.4 80.8 78.3 48.3 66.0 35.0 61.0 60.5 60.3 55.1 56.2 68.7 65.7 52.3 87.8 81.4 54.0 55.2 58.7 66.5 58.1 28.6 65.6 48.5 43.4 64.7 62.7 26.9 64.5 55.7 5.7 2.8 4.8 6.1 2.9 4.9 5.3 4.0 4.4 2.1 2.6 4.0 4.8 3.3 4.0 4.3 3.2 4.9 2.3 83.9 89.3 84.2 96.1 87.7 83.5 74.7 81.9 78.3 76.3 92.6 81.1 87.0 22.4 19.2 128.6 46.7 15.8 34.0 15.0 34.7 88.9 49.0 43.9 10.1 54.3 24.5 46.0 31.3 35.3 111.7 39.8 27.4 14.8 17.0 62.0 109.0 39.7 44.3 42.3 138.2 15.8 40.5 67.5 25.0 55.3 22.9 60.3 43.5 33.6 39.4 70.7 136.4 27.9 24.4 37.6 20.4 17.2 60.3 40.1 37.4 52.5 29.9 88.3 110.2 102.5 147.5 16.6 30.2 48.9 58.6 32.9 27.1 23.6 26.6 60.5 39.5 53.3 61.8 68.7 84.1 32.9 17.2 32.7 59.7 41.4 30.4 31.5 PTPRB PTPB ENSG00000127329 "Protein tyrosine phosphatase receptor type B" P23467 12 70515870-70637440 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" Angiogenesis "Hydrolase, Protein phosphatase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Adipocytes: 215.9;Endothelial cells: 211.5;Hepatic stellate cells: 504.0;Microglial cells: 164.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "EFO-21: 24.3;hTERT-RPE1: 19.7;HUVEC TERT2: 61.4;TIME: 90.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004782, HPA067868" Uncertain Approved "Vesicles,Plasma membrane,Cell Junctions" NA NA 14000000 "Cluster 43: B-cells - Humoral immune response" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Plasma membrane" "Vesicles, Cell Junctions" "CAB004782: , HPA067868: AB_2685911" "unprognostic (3.18e-1)" "unprognostic (2.99e-6)" "unprognostic (1.56e-1)" "unprognostic (1.80e-1)" "unprognostic (3.55e-2)" "unprognostic (1.77e-2)" "prognostic favorable (6.05e-4)" "unprognostic (4.59e-1)" "unprognostic (2.22e-2)" "unprognostic (1.85e-1)" "unprognostic (2.28e-2)" "unprognostic (1.40e-1)" "prognostic favorable (1.02e-4)" "unprognostic (2.91e-2)" "unprognostic (7.18e-2)" "unprognostic (1.31e-1)" "unprognostic (1.38e-1)" 26.7 9.4 16.0 4.7 14.1 0.1 18.8 12.3 12.1 12.8 7.1 10.9 7.5 12.3 4.4 6.8 10.8 14.7 23.2 10.1 12.4 22.5 16.7 35.7 3.2 15.9 14.2 4.0 6.2 7.8 4.7 32.6 18.1 6.3 11.1 1.4 3.3 8.0 17.1 4.1 9.3 18.1 12.4 30.0 6.2 2.5 19.0 3.0 14.8 38.8 3.4 7.7 5.3 11.9 4.4 0.3 1.9 0.2 0.0 0.1 0.9 0.9 4.2 2.2 5.2 0.1 3.4 1.7 24.3 0.6 0.4 15.2 0.2 0.7 7.8 1.3 0.7 0.4 1.7 1.1 0.2 0.7 0.0 0.1 0.7 6.1 0.0 19.7 61.4 0.0 3.6 1.0 1.3 0.0 0.1 0.0 2.3 4.4 0.9 0.1 1.6 0.9 11.3 1.8 0.0 0.8 1.6 0.0 3.5 0.4 0.0 1.5 90.3 0.9 0.9 0.4 5.4 1.1 0.9 0.8 0.4 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 16.0 14.1 12.3 12.1 10.1 12.4 15.9 14.2 18.1 12.4 19.0 11.9 215.9 0.0 13.2 2.0 3.1 3.7 0.8 1.0 0.0 7.1 0.9 0.9 12.3 11.5 1.3 3.7 0.0 0.0 2.0 12.8 0.0 1.5 4.6 2.2 0.7 211.5 0.0 16.0 52.5 0.9 0.0 7.3 1.5 4.0 25.2 0.5 504.0 4.7 0.4 5.0 68.8 6.4 0.0 20.0 4.6 3.0 1.2 1.2 5.4 164.9 0.0 0.4 0.0 2.5 2.9 12.2 11.1 0.0 0.1 0.8 3.2 0.1 0.2 0.9 0.0 6.4 5.2 0.7 0.7 0.9 1.6 0.0 1.0 1.8 6.8 0.7 PTPRC "CD45, GP180, LCA, T200" ENSG00000081237 "Protein tyrosine phosphatase receptor type C" P08575 1 198638457-198757476 "Cancer-related genes, CD markers, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Host-virus interaction" "Hydrolase, Protein phosphatase" "Cancer-related genes, Disease variant, SCID" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 208.6;lymphoid tissue: 329.9" "Cell type enhanced" "Detected in many" "B-cells: 525.2;dendritic cells: 1026.4;Macrophages: 534.1;monocytes: 554.9;NK-cells: 769.3;Plasma cells: 474.2;T-cells: 1049.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "Daudi: 209.9;HEL: 118.0;HL-60: 108.1;JURKAT: 266.4;MOLT-4: 161.1;THP-1: 87.0;U-266/70: 93.7;U-266/84: 91.2;U-698: 123.4;U-937: 94.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB000052, HPA000440, CAB002800, CAB056154, CAB068221" Enhanced Uncertain Nucleoplasm,Vesicles "Intracellular and membrane" NA NA 24000000 "Cluster 14: Monocytes - Unknown function" "Cluster 3: T-cells - Adaptive immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" "Nucleoplasm, Vesicles" "CAB000052: AB_2314143, CAB002800: AB_2237910, CAB056154: AB_2665572, CAB068221: AB_2665571, HPA000440: AB_611377" "unprognostic (1.51e-2)" "unprognostic (1.24e-2)" "unprognostic (5.10e-3)" "unprognostic (2.33e-3)" "unprognostic (1.30e-1)" "unprognostic (2.40e-3)" "unprognostic (1.62e-1)" "unprognostic (3.17e-2)" "unprognostic (1.25e-1)" "unprognostic (3.18e-2)" "unprognostic (8.08e-2)" "unprognostic (3.95e-1)" "prognostic unfavorable (2.42e-4)" "unprognostic (2.31e-1)" "unprognostic (3.43e-2)" "unprognostic (6.41e-2)" "unprognostic (7.06e-2)" 32.8 11.6 3.8 248.5 3.3 208.6 13.9 4.4 4.3 14.9 6.9 26.4 27.4 11.3 5.6 15.1 8.4 45.7 7.3 3.5 5.6 7.0 29.6 68.6 329.9 12.9 8.6 5.7 5.6 4.0 2.9 23.5 11.5 11.6 30.5 2.0 13.8 6.6 4.6 5.7 42.9 25.3 7.9 202.5 37.9 5.5 6.9 306.9 7.0 7.6 251.2 62.1 5.2 14.7 0.4 0.0 0.2 0.2 0.0 0.0 0.8 0.3 0.3 0.1 0.0 0.0 0.1 209.9 0.3 0.7 0.2 0.3 0.0 0.2 0.4 0.6 0.0 118.0 0.2 0.1 0.0 108.1 0.7 0.0 0.0 0.3 0.0 0.4 0.5 266.4 2.4 3.3 0.3 0.1 161.1 65.0 0.5 0.2 0.2 4.6 0.4 0.3 0.1 0.1 1.2 1.8 0.1 0.4 0.5 0.2 0.3 87.0 1.3 0.0 0.8 0.8 0.4 93.7 91.2 123.4 0.1 94.5 0.4 226.1 480.0 521.4 634.4 885.8 541.8 249.0 437.0 618.1 385.8 245.8 489.8 494.1 844.3 506.9 1015.8 57.4 508.6 1340.6 3.8 3.3 4.4 4.3 3.5 5.6 12.9 8.6 11.5 7.9 6.9 14.7 12.6 44.8 62.3 0.7 525.2 15.8 0.9 0.0 4.0 0.3 6.0 9.3 4.6 5.7 14.2 1.8 0.0 0.6 1026.4 1.0 0.0 0.7 2.4 2.3 2.3 15.1 1.2 58.8 0.7 0.0 0.9 17.2 46.9 2.7 246.5 0.1 14.6 6.9 96.0 0.0 1.7 0.4 0.0 334.9 214.5 3.5 1.2 534.1 21.4 201.4 554.9 0.1 769.3 2.5 0.7 0.1 0.8 0.0 474.2 1.1 0.1 2.5 11.7 0.2 6.6 7.4 6.7 0.3 0.6 1.8 15.2 0.8 1049.1 5.4 0.9 0.8 PTPRD "HPTP, PTPD" ENSG00000153707 "Protein tyrosine phosphatase receptor type D" P23468 9 8314246-10612723 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protein phosphatase, Receptor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 70.8" "Group enriched" "Detected in many" 12 "Excitatory neurons: 4579.7;Inhibitory neurons: 1152.9;Oligodendrocyte precursor cells: 1170.2;Oligodendrocytes: 3151.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 21.1;HAP1: 4.3;HSkMC: 6.3;RH-30: 8.1;SCLC-21H: 4.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054829 Uncertain Approved Nucleoplasm,Vesicles "Intracellular and membrane" NA NA 20000000 "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 12: NES - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Vesicles Nucleoplasm "HPA054829: AB_2682618" "unprognostic (4.74e-1)" "unprognostic (4.79e-2)" "unprognostic (1.44e-2)" "unprognostic (7.86e-2)" "unprognostic (2.34e-1)" "unprognostic (9.90e-2)" "unprognostic (1.85e-1)" "unprognostic (1.66e-1)" "unprognostic (1.91e-2)" "unprognostic (2.13e-2)" "unprognostic (7.52e-3)" "unprognostic (2.62e-1)" "prognostic favorable (7.45e-6)" "unprognostic (3.56e-4)" "unprognostic (7.59e-2)" "unprognostic (4.84e-2)" "unprognostic (3.08e-3)" 2.1 0.6 10.8 0.3 24.7 0.1 0.9 12.2 26.2 5.6 0.0 3.3 1.8 2.4 0.2 0.6 2.2 1.0 2.5 14.4 7.2 6.6 3.6 4.6 0.0 14.6 10.1 12.1 1.3 18.7 4.3 5.3 19.1 1.9 2.5 6.4 0.5 0.6 0.9 0.7 5.0 1.0 10.4 0.4 0.9 1.6 17.6 0.7 3.4 0.8 0.0 2.2 3.4 70.8 0.0 0.1 21.1 0.0 0.3 0.8 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.3 0.0 0.0 0.0 2.7 3.6 0.5 0.0 0.0 0.0 0.1 6.3 0.1 0.0 0.2 0.0 0.7 0.0 0.0 0.0 0.0 0.0 2.6 0.0 3.4 0.0 3.2 2.3 8.1 0.0 1.8 0.0 4.8 0.1 0.0 0.0 0.0 1.3 0.0 0.0 0.0 1.3 0.2 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.8 24.7 12.2 26.2 14.4 7.2 14.6 10.1 19.1 10.4 17.6 70.8 0.5 0.0 3.2 199.2 0.1 0.5 0.4 3.2 6.2 134.2 0.3 0.1 6.5 27.1 1.8 5.5 16.7 0.3 0.0 16.4 0.0 3.6 15.8 0.8 15.0 1.2 35.4 0.0 4579.7 0.0 0.3 15.5 0.5 1.0 0.0 9.2 1.4 13.5 1.3 5.0 1152.9 13.2 0.0 0.8 0.0 6.5 15.8 1.6 0.0 85.3 0.1 36.1 0.0 1170.2 3151.1 0.2 9.2 0.0 2.7 2.1 18.3 26.3 0.2 7.8 0.0 4.0 5.8 2.4 3.2 0.4 0.9 0.3 0.8 6.0 8.7 0.1 PTPRE PTPE ENSG00000132334 "Protein tyrosine phosphatase receptor type E" P23469 10 127907103-128085855 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 46.9" "Cell type enhanced" "Detected in many" "dendritic cells: 256.6;Inhibitory neurons: 191.6;Langerhans cells: 307.9;Macrophages: 276.3;Oligodendrocyte precursor cells: 247.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 634.6;plasmacytoid DC: 475.9" "Group enriched" "Detected in all" 12 "dendritic cells: 475.9;granulocytes: 634.6;monocytes: 175.4" "Cell line enhanced" "Detected in many" "hTERT-RPE1: 38.6;HUVEC TERT2: 41.6;NB-4: 32.5;TIME: 79.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015870, HPA021872" Supported Approved "Intermediate filaments" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 41: Macrophages - Immune response" "Intermediate filaments" "HPA015870: AB_1855759, HPA021872: AB_1855760" "unprognostic (5.23e-2)" "unprognostic (1.37e-1)" "unprognostic (1.99e-1)" "unprognostic (7.11e-2)" "unprognostic (3.19e-1)" "unprognostic (9.67e-2)" "unprognostic (6.50e-2)" "unprognostic (4.49e-2)" "unprognostic (2.11e-1)" "unprognostic (2.56e-2)" "unprognostic (8.71e-3)" "unprognostic (2.00e-1)" "prognostic unfavorable (4.08e-5)" "unprognostic (1.52e-1)" "unprognostic (6.71e-3)" "unprognostic (2.49e-2)" "unprognostic (5.59e-2)" 13.6 16.7 13.9 25.3 8.9 46.9 6.7 5.7 13.9 3.9 7.7 9.2 9.5 3.5 2.6 7.9 4.9 10.3 10.6 14.2 11.1 4.3 4.4 16.0 16.4 11.6 9.0 1.6 2.7 2.7 5.0 7.8 10.7 3.4 9.3 1.0 5.8 2.4 1.3 4.7 12.9 7.4 10.8 20.6 7.4 2.6 10.7 8.6 5.5 3.1 9.8 12.7 4.4 14.2 4.3 0.9 0.5 0.0 2.5 0.4 7.5 0.1 0.0 1.6 3.6 1.7 25.1 3.3 2.6 2.1 5.2 2.3 2.1 12.2 0.7 4.0 1.9 0.4 1.4 0.0 4.1 16.2 11.6 0.8 6.9 6.1 12.1 38.6 41.6 10.3 0.0 1.9 2.6 4.0 4.9 32.5 0.2 4.6 1.5 19.1 2.6 6.4 6.8 18.0 0.0 2.5 7.4 1.3 0.3 1.8 0.6 20.1 79.5 1.7 1.8 7.8 8.9 0.9 1.3 4.6 11.3 12.5 0.0 174.3 175.4 147.2 36.6 64.5 22.3 7.7 16.5 25.1 97.9 8.3 11.5 19.6 634.6 31.6 54.9 475.9 26.7 43.3 13.9 8.9 5.7 13.9 14.2 11.1 11.6 9.0 10.7 10.8 10.7 14.2 25.0 83.3 57.2 22.5 26.2 59.5 54.3 42.4 15.9 5.2 14.2 23.6 20.3 8.6 23.7 3.7 0.0 43.2 256.6 15.7 0.0 3.7 2.1 3.6 10.6 78.0 6.7 10.3 112.7 4.4 67.4 17.5 10.7 7.7 31.6 3.7 47.5 2.3 57.5 0.0 191.6 15.8 18.3 166.7 307.9 2.5 0.6 276.3 24.9 165.8 139.5 0.0 150.4 247.3 93.4 49.2 13.3 0.4 38.5 21.3 13.9 2.2 7.8 0.9 0.0 86.0 12.8 0.5 1.9 20.4 64.6 17.0 59.3 9.2 11.7 40.3 PTPRF LAR ENSG00000142949 "Protein tyrosine phosphatase receptor type F" P10586 1 43525187-43623666 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion" "Heparin-binding, Hydrolase, Protein phosphatase, Receptor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 259.9;Extravillous trophoblasts: 290.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "SK-BR-3: 314.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA012710 Uncertain Approved "Golgi apparatus" "Intracellular and membrane" NA NA 160000000 "Cluster 37: Intestine - Unknown function" "Cluster 28: BEWO - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Golgi apparatus" "HPA012710: AB_1855933" "unprognostic (8.20e-2)" "unprognostic (2.41e-2)" "unprognostic (3.01e-2)" "unprognostic (9.17e-2)" "unprognostic (8.34e-2)" "unprognostic (1.11e-1)" "prognostic unfavorable (3.47e-4)" "unprognostic (4.59e-1)" "unprognostic (1.51e-1)" "unprognostic (4.97e-2)" "unprognostic (4.68e-2)" "unprognostic (7.07e-2)" "unprognostic (1.99e-2)" "prognostic favorable (7.03e-4)" "unprognostic (2.33e-1)" "unprognostic (3.19e-2)" "unprognostic (2.58e-1)" 91.7 11.9 47.1 14.0 48.4 1.8 57.4 22.3 45.6 36.3 4.7 79.5 70.5 28.0 71.9 101.7 70.5 30.4 7.6 45.3 39.9 27.7 107.2 35.4 4.7 33.1 43.6 22.1 56.8 31.1 23.5 55.7 33.1 67.3 51.4 24.7 101.7 43.1 2.7 107.9 78.5 35.0 30.4 4.0 49.7 9.4 45.6 29.6 23.8 3.4 26.2 40.0 51.2 37.4 165.6 76.5 49.0 58.0 11.2 0.6 274.3 92.1 36.1 73.9 62.6 82.0 214.9 0.4 25.6 40.2 59.2 124.7 57.5 200.7 89.1 2.0 72.1 1.0 48.7 75.3 33.8 1.2 1.3 11.3 113.2 106.4 174.9 92.6 111.5 7.7 25.4 7.1 27.5 94.0 1.2 1.3 75.9 89.8 21.0 57.2 86.9 3.7 28.3 241.5 73.3 28.0 90.8 314.0 11.8 128.8 91.5 17.3 88.2 1.6 116.5 7.5 126.1 3.1 2.7 0.4 7.4 3.9 233.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 47.1 48.4 22.3 45.6 45.3 39.9 33.1 43.6 33.1 30.4 45.6 37.4 2.3 157.0 101.1 39.2 2.3 62.8 51.3 67.4 52.9 33.5 146.3 102.9 7.6 130.1 74.9 86.5 43.8 64.3 1.4 259.9 0.0 147.4 4.9 80.6 17.2 7.7 100.9 8.0 40.6 120.8 290.1 19.8 93.8 70.6 5.1 72.8 10.4 159.6 14.1 185.1 16.1 171.7 50.8 4.9 5.8 8.5 6.8 3.4 12.4 7.5 2.9 27.2 2.1 16.6 68.1 165.0 124.7 7.2 1.8 68.0 208.1 13.9 128.3 31.0 0.0 15.8 18.5 9.0 37.5 107.5 91.4 66.2 3.9 9.6 142.5 78.7 PTPRG "PTPG, RPTPG" ENSG00000144724 "Protein tyrosine phosphatase receptor type G" P23470 3 61561569-62297609 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in many" 4 "Astrocytes: 356.8;Excitatory neurons: 416.1;Inhibitory neurons: 684.3;Microglial cells: 771.0;Oligodendrocyte precursor cells: 920.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 81.7;HSkMC: 61.1" "Low region specificity" "Detected in all" "HPA000546, HPA064237" Uncertain Approved "Plasma membrane" NA NA 520000000 "Cluster 89: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 68: Oligodendrocytes - Mixed function" "Plasma membrane" "HPA000546: , HPA064237: AB_2685221" "unprognostic (1.47e-1)" "unprognostic (1.03e-1)" "unprognostic (1.31e-2)" "unprognostic (1.93e-1)" "unprognostic (8.73e-2)" "unprognostic (3.26e-1)" "unprognostic (5.38e-2)" "unprognostic (1.18e-2)" "unprognostic (5.84e-2)" "unprognostic (2.28e-1)" "unprognostic (2.86e-1)" "unprognostic (1.14e-1)" "prognostic favorable (3.10e-6)" "unprognostic (9.91e-2)" "unprognostic (3.25e-1)" "unprognostic (1.19e-1)" "unprognostic (2.63e-2)" 18.0 13.2 7.6 4.6 7.8 0.0 12.8 4.9 10.4 11.9 23.4 8.2 3.7 10.6 8.4 4.1 9.0 8.3 10.0 13.7 6.2 14.4 5.8 12.8 1.8 8.4 7.2 12.0 3.9 26.6 5.2 9.9 5.9 7.8 6.1 8.6 5.2 8.4 7.4 4.5 5.9 13.0 10.0 7.0 5.8 7.7 9.1 2.1 13.1 10.4 1.7 7.0 6.7 5.0 0.0 5.3 27.3 0.0 81.7 41.6 13.5 17.6 28.5 18.2 24.4 13.2 0.5 0.6 10.1 20.7 14.5 0.2 13.4 13.6 28.3 1.5 7.7 1.4 0.1 15.0 27.5 7.5 0.1 61.1 5.3 25.9 30.9 5.8 19.7 2.0 0.0 17.3 16.3 7.6 0.0 0.1 17.0 0.1 0.0 11.9 8.6 0.6 18.2 8.2 2.1 4.5 4.3 0.1 6.9 11.2 0.2 0.3 46.0 25.4 24.1 41.0 14.7 5.5 6.8 0.0 19.2 3.2 31.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 7.6 7.8 4.9 10.4 13.7 6.2 8.4 7.2 5.9 10.0 9.1 5.0 45.3 12.8 32.4 356.8 2.2 9.2 6.4 5.0 13.1 98.5 9.6 6.3 12.5 8.6 5.8 22.0 6.2 10.5 0.9 12.1 5.9 9.6 3.6 14.4 31.9 55.5 24.6 0.0 416.1 1.8 0.8 47.7 4.1 30.5 0.0 64.6 90.3 32.7 19.7 154.8 684.3 8.9 22.4 2.9 8.8 4.3 66.5 1.1 17.8 771.0 0.6 40.8 2.1 920.3 11.8 5.3 5.6 56.8 4.2 10.9 13.9 18.2 2.8 5.7 72.3 81.1 60.6 2.0 8.6 2.1 4.8 12.6 2.3 20.0 12.1 2.7 PTPRH SAP-1 ENSG00000080031 "Protein tyrosine phosphatase receptor type H" Q9HD43 19 55181247-55209506 "Enzymes, Metabolic proteins, Predicted membrane proteins" Apoptosis "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 24.2;intestine: 68.6;stomach 1: 23.6" "Cell type enhanced" "Detected in many" "Distal enterocytes: 123.6;Gastric mucus-secreting cells: 60.1;Paneth cells: 94.9;Proximal enterocytes: 113.1" "Cancer enhanced" "Detected in many" "pancreatic cancer: 16.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HHSteC: 11.8;K-562: 15.0;OE19: 30.9;SK-MEL-30: 22.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA042300 Approved Mitochondria NA NA "Cluster 56: Intestine - Transmembrane transport" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" Mitochondria "HPA042300: AB_10796900" "unprognostic (1.87e-1)" "unprognostic (1.10e-1)" "unprognostic (2.59e-1)" "unprognostic (7.57e-3)" "unprognostic (5.01e-3)" "unprognostic (8.14e-2)" "unprognostic (1.15e-1)" "unprognostic (1.96e-3)" "unprognostic (1.60e-2)" "unprognostic (1.06e-1)" "unprognostic (9.96e-2)" "unprognostic (6.16e-2)" "unprognostic (1.47e-11)" "unprognostic (4.08e-3)" "unprognostic (2.47e-1)" "unprognostic (1.52e-2)" "unprognostic (1.57e-1)" 1.3 16.9 1.7 3.6 4.4 0.0 0.6 5.2 3.0 0.8 0.9 27.9 67.7 0.7 0.1 0.3 0.5 24.2 1.1 1.7 3.4 0.2 13.3 0.1 0.1 7.1 4.9 0.3 4.6 0.1 5.1 0.1 5.7 0.2 21.2 1.3 0.1 0.0 0.0 0.1 68.6 2.1 3.8 22.2 23.6 0.8 4.8 0.0 0.1 0.0 0.1 5.7 0.6 7.2 6.9 4.2 0.0 1.6 1.3 3.6 0.1 0.1 3.6 0.7 1.4 1.8 9.5 0.0 0.3 0.6 8.2 0.0 0.0 0.0 0.8 0.1 0.1 0.5 0.1 4.9 11.8 0.0 4.8 1.0 2.9 2.3 3.6 0.4 0.2 0.0 15.0 0.6 0.0 0.0 0.0 0.3 0.0 30.9 9.8 0.0 0.0 0.5 0.0 0.0 0.4 1.0 0.0 4.2 22.4 0.0 0.0 1.9 0.0 1.0 1.4 0.5 0.1 0.0 3.7 0.0 1.1 0.1 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.7 4.4 5.2 3.0 1.7 3.4 7.1 4.9 5.7 3.8 4.8 7.2 0.3 0.0 0.0 0.0 0.4 1.8 2.8 1.9 0.0 0.1 0.2 0.3 0.6 21.5 3.8 1.8 0.0 0.0 0.0 123.6 0.0 15.5 0.0 1.2 1.0 0.5 4.8 0.0 0.8 25.8 0.1 1.1 60.1 0.5 0.0 4.1 0.7 5.7 0.2 16.8 0.7 20.8 0.0 0.0 1.1 0.3 0.0 0.4 0.0 1.0 0.6 0.2 1.0 0.0 5.8 26.9 94.9 0.0 0.4 3.4 113.1 0.0 4.5 0.5 0.0 3.1 1.8 0.3 0.2 0.0 1.1 0.1 0.5 3.6 18.7 19.7 PTPRJ "CD148, DEP1, HPTPeta" ENSG00000149177 "Protein tyrosine phosphatase receptor type J" Q12913 11 47980558-48170841 "CD markers, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Inhibitory neurons: 167.5;Microglial cells: 189.3;Oligodendrocyte precursor cells: 239.8;Oligodendrocytes: 167.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 9.5" "Group enriched" "Detected in many" 4 "granulocytes: 9.5;monocytes: 4.7" "Cell line enhanced" "Detected in many" "RPTEC TERT1: 52.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006026 Approved "Intracellular and membrane" NA NA 670000000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 68: Oligodendrocytes - Mixed function" "HPA006026: AB_1078446" "unprognostic (1.46e-1)" "unprognostic (2.21e-1)" "unprognostic (1.55e-1)" "unprognostic (3.83e-2)" "unprognostic (3.20e-2)" "unprognostic (2.99e-2)" "unprognostic (6.58e-2)" "unprognostic (2.15e-1)" "unprognostic (9.64e-3)" "unprognostic (3.79e-3)" "unprognostic (5.16e-2)" "unprognostic (1.89e-1)" "prognostic favorable (1.13e-5)" "unprognostic (1.09e-2)" "unprognostic (7.98e-2)" "unprognostic (9.18e-2)" "unprognostic (2.00e-1)" 6.0 3.2 10.2 20.5 13.8 29.5 6.1 6.9 14.9 6.2 18.5 10.2 9.4 2.4 7.8 1.9 4.1 7.1 2.7 10.0 12.7 13.9 11.9 10.0 15.5 9.7 11.7 1.6 6.1 15.8 10.1 7.6 12.4 7.9 8.7 8.1 10.1 7.0 2.4 4.2 14.5 5.9 6.0 23.3 14.6 2.3 18.5 7.0 19.6 2.7 11.0 6.9 2.1 14.7 7.6 28.3 12.1 7.0 1.9 4.1 4.2 7.5 5.5 12.9 9.2 2.0 40.8 6.9 51.8 19.1 19.6 6.0 19.0 2.0 14.9 46.6 5.4 1.9 34.9 2.8 12.1 2.7 41.5 3.2 0.6 3.8 1.0 31.7 7.8 0.5 2.6 4.4 4.7 17.0 0.1 17.3 9.7 25.7 4.4 1.6 1.6 4.0 52.6 11.1 7.9 2.5 20.2 12.0 19.4 8.9 13.0 20.3 25.7 9.9 10.8 20.5 23.4 1.1 1.7 11.4 11.7 8.0 37.3 0.7 1.1 2.8 1.6 2.0 1.0 0.8 0.9 1.2 0.8 0.5 0.7 0.9 9.5 1.0 4.7 1.5 1.0 0.8 10.2 13.8 6.9 14.9 10.0 12.7 9.7 11.7 12.4 6.0 18.5 14.7 1.5 9.6 16.7 43.1 11.3 0.3 9.8 0.8 0.6 13.6 8.3 4.1 3.7 17.2 13.0 38.6 6.2 1.9 32.7 35.5 0.0 7.4 5.5 13.5 2.2 4.5 12.6 3.2 81.0 5.0 0.6 4.0 22.4 22.9 13.9 2.5 5.0 15.6 30.0 10.1 167.5 10.1 2.0 74.2 5.7 8.2 0.3 40.2 1.8 189.3 36.0 10.3 21.6 239.8 167.7 11.8 28.0 0.4 12.9 25.3 37.6 13.5 4.9 1.3 0.0 3.3 4.9 0.2 4.8 0.5 0.3 1.9 22.0 2.3 7.6 8.2 PTPRK R-PTP-kappa ENSG00000152894 "Protein tyrosine phosphatase receptor type K" Q15262 6 127968785-128520616 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protein phosphatase, Receptor" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 889.9;Oligodendrocyte precursor cells: 313.1;Oligodendrocytes: 1278.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 6 "memory B-cell: 1.6;naive B-cell: 2.9" "Lineage enriched" "Detected in single" 7 "B-cells: 2.9" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA054056, HPA054822" Uncertain Supported "Vesicles,Plasma membrane,Cell Junctions" NA NA 13000000 "Cluster 21: B-cells - Adaptive immune response" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Cell Junctions" "Vesicles, Plasma membrane" "HPA054056: AB_2682359, HPA054822: AB_2682614" "unprognostic (3.15e-2)" "unprognostic (1.07e-2)" "unprognostic (5.79e-3)" "unprognostic (4.95e-3)" "unprognostic (1.89e-2)" "unprognostic (7.26e-2)" "unprognostic (3.27e-1)" "unprognostic (6.06e-2)" "unprognostic (2.04e-1)" "unprognostic (1.08e-1)" "prognostic unfavorable (1.99e-4)" "unprognostic (1.46e-1)" "prognostic favorable (9.33e-5)" "unprognostic (2.10e-1)" "unprognostic (1.55e-1)" "unprognostic (2.59e-1)" "unprognostic (9.32e-2)" 10.7 4.2 13.4 9.7 20.6 0.2 25.6 16.7 18.6 13.5 8.6 27.3 32.8 12.1 8.2 9.7 14.9 32.5 12.4 15.9 14.5 14.9 29.6 19.4 6.9 16.8 16.7 15.1 26.2 10.2 7.0 21.8 17.8 18.9 27.6 4.6 15.3 19.0 5.9 12.2 28.5 15.9 14.5 7.9 30.5 2.2 16.4 10.2 11.7 9.9 8.7 20.9 12.3 29.8 17.3 16.7 10.9 1.0 24.9 31.9 11.0 43.6 86.3 18.4 16.6 28.8 15.0 0.1 13.4 40.7 50.8 49.0 10.2 35.9 26.7 50.3 19.4 0.3 23.6 45.7 29.7 0.0 1.7 23.9 35.4 35.9 49.6 50.8 54.0 14.7 0.0 1.1 49.3 33.6 26.6 0.1 11.9 34.5 22.6 94.8 21.7 3.1 51.1 33.4 43.8 0.1 45.2 55.6 2.7 12.4 14.6 1.1 86.9 30.0 18.4 54.8 42.2 0.7 6.0 0.0 38.1 0.0 31.1 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 2.9 0.1 0.3 0.0 0.2 0.0 0.0 0.1 0.1 13.4 20.6 16.7 18.6 15.9 14.5 16.8 16.7 17.8 14.5 16.4 29.8 39.2 25.6 33.5 155.7 17.5 63.5 88.1 45.2 60.3 7.3 56.6 26.5 22.2 101.5 44.1 18.4 4.2 24.8 0.8 75.2 0.0 63.2 4.6 30.6 11.5 46.6 43.9 0.0 889.9 61.3 4.1 28.6 77.5 77.5 1.3 13.4 11.4 40.9 6.4 10.1 55.3 44.2 8.2 1.6 8.8 2.7 17.1 2.2 17.8 200.5 1.7 5.1 0.0 313.1 1278.1 124.2 53.8 18.0 1.0 115.8 68.7 13.4 25.9 0.7 59.2 20.1 41.5 11.3 8.9 27.0 38.1 26.8 3.4 14.1 56.6 157.0 PTPRM "hR-PTPu, PTPRL1, RPTPU" ENSG00000173482 "Protein tyrosine phosphatase receptor type M" P28827 18 7566782-8406861 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion" "Hydrolase, Protein phosphatase, Receptor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 142.0;Astrocytes: 188.1;Inhibitory neurons: 751.6;Microglial cells: 263.3;Oligodendrocyte precursor cells: 224.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "memory CD8 T-cell: 4.7" "Group enriched" "Detected in many" 33 "dendritic cells: 1.8;T-cells: 4.7" "Cell line enhanced" "Detected in many" "ASC diff: 98.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003891, CAB022442, CAB022443" Supported Approved "Plasma membrane" NA Yes 130000000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 39: Non-specific - Mitochondria" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane" "CAB022442: , CAB022443: , HPA003891: AB_2667073" "unprognostic (2.59e-1)" "prognostic unfavorable (8.65e-5)" "unprognostic (4.89e-2)" "unprognostic (1.00e-1)" "unprognostic (1.13e-1)" "unprognostic (1.46e-1)" "unprognostic (1.80e-1)" "unprognostic (3.41e-2)" "unprognostic (7.62e-2)" "unprognostic (2.74e-2)" "unprognostic (1.56e-2)" "unprognostic (9.64e-2)" "unprognostic (5.63e-2)" "unprognostic (3.11e-3)" "unprognostic (9.41e-2)" "unprognostic (2.63e-2)" "prognostic favorable (1.07e-4)" 53.1 24.1 18.9 11.9 37.6 1.2 41.8 13.0 27.7 18.4 44.2 25.3 8.7 24.2 11.9 14.2 23.3 32.4 61.2 12.7 38.7 29.5 11.8 38.9 15.5 21.7 53.0 26.4 13.2 23.4 16.1 33.2 34.3 16.7 11.5 19.3 10.9 36.0 52.5 12.3 15.1 24.8 5.8 23.1 18.4 22.8 47.6 16.7 54.8 63.4 11.9 23.9 12.2 14.4 4.6 33.4 15.7 0.2 98.0 67.4 38.7 41.1 35.6 26.9 39.5 30.9 7.1 0.0 39.0 49.1 0.5 0.3 0.2 14.3 36.9 0.5 7.2 0.0 22.2 15.2 27.9 0.0 0.4 77.1 29.3 14.9 42.1 51.1 27.2 0.0 0.0 13.8 21.8 0.7 13.7 0.3 2.6 9.9 7.3 0.5 13.5 63.9 64.9 57.6 1.4 8.6 1.1 0.2 34.6 24.9 0.2 0.0 28.2 54.9 34.6 26.4 7.2 1.1 0.4 0.3 46.8 0.2 10.4 0.0 0.0 0.0 2.8 0.0 1.1 0.0 3.8 4.7 0.0 0.0 1.0 2.0 0.0 0.0 0.0 1.8 0.7 1.1 18.9 37.6 13.0 27.7 12.7 38.7 21.7 53.0 34.3 5.8 47.6 14.4 142.0 44.8 36.0 188.1 1.1 6.0 7.3 3.0 2.8 28.3 2.5 3.2 26.7 14.3 7.1 5.5 2.1 11.4 5.4 0.9 1.9 17.6 25.9 28.9 15.6 68.9 1.8 0.4 70.1 8.3 3.4 14.0 8.2 59.6 2.5 13.0 47.2 25.3 9.9 0.0 751.6 1.4 0.0 8.0 5.7 42.0 2.8 5.1 30.2 263.3 0.6 2.9 3.1 224.7 50.3 14.3 1.2 5.3 2.3 8.3 3.0 13.3 15.6 2.2 6.6 7.4 9.9 8.6 9.9 0.9 2.8 12.6 5.7 3.7 0.8 8.6 PTPRN "IA-2, ICA512" ENSG00000054356 "Protein tyrosine phosphatase receptor type N" Q16849 2 219289623-219309648 "Disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Transcription, Transcription regulation" Receptor "Diabetes mellitus" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "brain: 234.3;pituitary gland: 182.3" "Group enriched" "Detected in some" 9 "Bipolar cells: 59.0;Cone photoreceptor cells: 60.5;Enteroendocrine cells: 47.1;Excitatory neurons: 44.6;Horizontal cells: 97.6;Inhibitory neurons: 48.1;Rod photoreceptor cells: 38.4" "Group enriched" "Detected in some" 12 "glioma: 5.3;pancreatic cancer: 18.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "U-2 OS: 66.4;U-87 MG: 249.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007152, HPA007179" Enhanced Approved "Endoplasmic reticulum" NA NA 38000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 62: Horizontal cells - Visual perception" "Endoplasmic reticulum" "HPA007152: AB_2667759, HPA007179: AB_1079714" "unprognostic (1.43e-1)" "unprognostic (1.33e-4)" "unprognostic (2.91e-3)" "unprognostic (5.83e-3)" "prognostic unfavorable (1.45e-7)" "unprognostic (3.64e-2)" "unprognostic (1.24e-4)" "unprognostic (1.58e-3)" "unprognostic (1.02e-1)" "unprognostic (6.20e-4)" "unprognostic (1.44e-2)" "unprognostic (1.54e-1)" "unprognostic (2.28e-10)" "unprognostic (1.43e-2)" "unprognostic (2.49e-1)" "unprognostic (1.10e-2)" "unprognostic (8.61e-2)" 0.7 25.2 91.6 4.8 98.3 0.6 0.2 12.2 139.0 0.2 0.0 5.3 1.6 0.3 0.0 0.3 0.1 0.3 0.3 116.6 234.3 0.3 0.2 0.2 0.1 62.4 85.5 0.2 36.3 0.0 182.3 0.2 138.1 0.4 0.8 21.4 0.1 0.0 0.1 0.9 2.0 1.6 22.2 0.1 6.0 0.7 98.9 0.0 0.4 0.0 0.0 0.9 0.9 70.1 0.1 0.0 0.1 0.0 0.0 0.0 0.2 2.5 0.0 0.8 0.0 0.1 0.0 0.0 1.2 4.6 6.8 0.4 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.8 1.9 0.0 0.6 8.4 0.0 20.8 0.0 0.2 0.0 0.0 0.4 0.5 1.5 0.0 0.1 0.0 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 16.6 10.8 0.0 0.0 0.0 9.0 0.0 0.1 0.0 0.1 66.4 0.0 0.2 0.1 0.3 1.1 249.1 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.6 91.6 98.3 12.2 139.0 116.6 234.3 62.4 85.5 138.1 22.2 98.9 70.1 0.0 0.0 0.0 5.5 0.1 0.1 0.1 0.1 0.0 59.0 0.1 0.1 2.0 0.0 0.0 0.0 60.5 0.0 0.1 0.1 1.9 0.1 0.3 0.1 0.2 0.7 47.1 2.7 44.6 0.0 0.3 1.9 2.6 0.0 0.0 0.0 0.0 0.3 0.1 97.6 48.1 0.7 2.0 0.0 0.4 0.8 0.3 1.8 1.8 4.7 0.0 6.0 0.0 1.5 4.0 2.7 0.0 0.0 0.1 0.2 0.0 0.1 0.0 38.4 0.0 0.1 1.9 4.2 2.7 0.0 0.1 0.0 0.1 0.0 0.1 0.2 PTPRN2 "IA-2beta, ICAAR, KIAA0387, phogrin" ENSG00000155093 "Protein tyrosine phosphatase receptor type N2" Q92932 7 157539056-158587823 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Lipid metabolism, Phospholipid metabolism" "Hydrolase, Protein phosphatase, Receptor" "Diabetes mellitus" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 49.9;pancreas: 98.1" "Group enriched" "Detected in many" 4 "Enteroendocrine cells: 131.1;Excitatory neurons: 439.6;Inhibitory neurons: 433.4;Oligodendrocyte precursor cells: 138.2" "Cancer enhanced" "Detected in all" "prostate cancer: 40.8" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "neutrophil: 23.6" "Lineage enriched" "Detected in all" 4 "granulocytes: 23.6" "Cell line enhanced" "Detected in many" "AF22: 45.5;HDLM-2: 42.0;MOLT-4: 22.1;NB-4: 43.0;SCLC-21H: 23.8;SH-SY5Y: 25.4;U-87 MG: 27.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006900, HPA007255, HPA026656" Enhanced Approved Vesicles NA NA 1600000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 22: Non-specific - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles "HPA006900: AB_1079715, HPA007255: , HPA026656: AB_1855912" "unprognostic (2.42e-1)" "unprognostic (4.17e-2)" "unprognostic (7.82e-2)" "unprognostic (2.69e-2)" "prognostic unfavorable (9.37e-5)" "unprognostic (7.12e-3)" "unprognostic (1.04e-1)" "unprognostic (4.55e-2)" "unprognostic (4.27e-2)" "unprognostic (1.64e-1)" "unprognostic (1.20e-2)" "unprognostic (1.39e-1)" "prognostic favorable (8.68e-4)" "unprognostic (2.60e-2)" "unprognostic (1.48e-1)" "unprognostic (1.43e-3)" "unprognostic (6.16e-2)" 3.8 16.5 29.4 2.7 34.3 1.3 2.9 0.0 49.9 2.1 0.0 7.7 8.3 3.0 4.2 1.9 10.8 7.6 3.1 35.2 22.7 3.9 1.6 4.8 3.4 7.9 3.1 8.7 98.1 1.0 41.0 2.1 3.4 17.3 6.1 9.2 12.9 3.6 1.2 0.8 6.7 2.1 0.1 13.4 40.2 6.2 14.1 1.6 8.7 1.9 2.5 4.2 2.1 20.5 0.1 0.4 45.5 3.6 0.1 0.2 0.1 0.4 0.3 0.0 0.1 0.0 4.0 0.0 1.2 0.5 9.4 0.3 1.0 0.0 0.0 42.0 0.8 0.0 0.0 7.3 1.1 0.0 0.1 2.0 0.8 0.1 0.5 0.3 0.0 3.4 0.1 0.3 0.0 0.7 22.1 43.0 5.7 13.7 3.2 0.0 2.7 0.2 0.2 0.0 23.8 25.4 0.0 0.1 0.0 0.0 0.0 20.9 6.2 9.2 4.3 0.1 1.5 0.3 0.1 0.0 27.7 17.4 6.8 14.1 1.5 2.8 1.3 0.2 0.5 3.5 2.1 1.4 2.1 4.2 2.4 1.4 23.6 2.4 0.0 0.6 5.3 1.3 29.4 34.3 0.0 49.9 35.2 22.7 7.9 3.1 3.4 0.1 14.1 20.5 40.7 3.2 12.9 16.3 18.4 2.3 12.7 1.3 4.0 30.2 1.9 2.2 3.1 10.0 9.1 40.5 10.4 0.4 8.7 5.9 35.2 22.9 51.9 8.7 2.5 26.3 131.1 6.6 439.6 13.1 0.4 13.0 41.8 0.8 19.0 14.1 44.3 0.8 44.5 11.8 433.4 43.3 6.1 7.0 11.3 19.3 12.5 7.9 12.4 27.2 5.7 67.3 15.5 138.2 11.0 7.3 7.0 19.5 5.4 15.0 6.5 3.8 52.6 8.0 26.3 1.4 7.0 62.8 16.3 4.8 1.4 0.7 14.8 32.7 9.7 24.8 PTPRO "GLEPP1, NPHS6, PTP-oc, PTP-U2, PTPU2" ENSG00000151490 "Protein tyrosine phosphatase receptor type O" Q16827 12 15322257-15602175 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protein phosphatase, Receptor" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 26.8;kidney: 36.3" "Group enriched" "Detected in many" 7 "Excitatory neurons: 193.6;Inhibitory neurons: 231.1;Oligodendrocyte precursor cells: 126.7" "Cancer enhanced" "Detected in many" "colorectal cancer: 8.7" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "GAMG: 9.9;NTERA-2: 5.8;SH-SY5Y: 6.1;THP-1: 2.7" "Region enhanced" "Detected in all" "olfactory bulb: 175.9" "Low region specificity" "Detected in all" HPA034525 Enhanced "Intracellular and membrane" NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 5: NTERA-2 - Transcription" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA034525: AB_10669785" "unprognostic (3.68e-2)" "unprognostic (3.49e-1)" "unprognostic (9.64e-2)" "unprognostic (1.25e-2)" "unprognostic (7.87e-2)" "unprognostic (2.08e-1)" "unprognostic (5.93e-3)" "unprognostic (5.37e-2)" "unprognostic (2.03e-1)" "unprognostic (3.72e-2)" "unprognostic (2.00e-1)" "unprognostic (5.43e-2)" "unprognostic (4.89e-2)" "unprognostic (2.12e-1)" "unprognostic (1.99e-2)" "unprognostic (1.24e-1)" "unprognostic (1.44e-1)" 1.8 0.8 8.7 3.0 9.4 0.2 0.8 0.0 10.3 1.3 0.1 10.4 1.7 4.8 1.4 0.4 1.0 1.2 0.5 9.8 8.9 36.3 1.3 6.8 3.1 2.2 3.3 0.4 0.4 0.3 2.4 4.4 5.3 0.5 26.8 7.5 0.5 0.8 0.3 0.4 2.0 6.6 0.9 3.4 0.8 0.5 9.5 1.2 0.3 0.5 3.2 1.5 0.4 2.9 0.0 0.1 0.3 0.1 0.2 0.0 0.2 0.0 0.0 0.5 1.3 0.0 0.0 0.1 0.1 0.0 9.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.2 0.0 0.0 0.6 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 5.8 1.2 0.0 0.0 0.0 0.0 0.1 0.2 1.5 6.1 0.9 0.0 0.1 0.1 0.1 2.7 0.0 0.0 0.3 0.0 0.2 0.4 0.0 0.3 0.0 0.1 1.2 0.0 6.0 0.0 0.0 12.3 0.0 8.9 1.7 0.4 8.5 8.6 2.8 1.2 0.1 0.1 12.7 10.9 1.4 3.2 8.7 9.4 0.0 10.3 9.8 8.9 2.2 3.3 5.3 0.9 9.5 2.9 0.2 0.0 0.5 7.5 7.0 0.3 1.3 0.5 0.0 25.2 0.0 0.1 0.7 0.0 1.8 16.5 0.0 0.2 4.0 3.9 0.0 0.4 0.0 0.8 0.2 1.1 3.6 0.0 193.6 0.0 0.2 0.9 0.0 0.6 0.0 0.0 1.1 0.2 26.1 25.2 231.1 8.3 0.0 21.1 10.6 0.6 0.6 10.5 0.0 17.8 13.8 0.6 1.0 126.7 6.3 0.1 9.8 0.4 1.0 0.1 0.1 0.2 0.0 4.8 0.0 2.1 0.7 0.6 1.1 0.1 0.4 0.3 1.0 0.1 22.4 0.8 PTPRR "EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ" ENSG00000153233 "Protein tyrosine phosphatase receptor type R" Q15256 12 70638073-70920738 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protein phosphatase, Receptor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 14.4;endometrium 1: 5.5;intestine: 7.6" "Group enriched" "Detected in some" 4 "Excitatory neurons: 199.5;Inhibitory neurons: 160.7" "Cancer enhanced" "Detected in many" "urothelial cancer: 3.6" "Group enriched" "Detected in many" 5 "amygdala: 3.7;basal ganglia: 5.7;cerebellum: 14.4;cerebral cortex: 6.5;hippocampal formation: 7.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "HDLM-2: 20.0;RT4: 37.4" "Region enriched" "Detected in all" 5 "cerebellum: 89.6" "CAB011461, HPA011851, HPA071067" Uncertain Supported "Plasma membrane,Cell Junctions,Cytosol" NA NA "Cluster 45: Intestine - Brush border" "Cluster 15: RT4 - Unknown function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane, Cell Junctions, Cytosol" "CAB011461: AB_298890, HPA011851: AB_1855939, HPA071067: AB_2686340" "unprognostic (4.98e-2)" "unprognostic (1.91e-2)" "unprognostic (1.55e-1)" "unprognostic (2.04e-1)" "unprognostic (3.63e-3)" "unprognostic (3.48e-5)" "unprognostic (5.44e-3)" "unprognostic (1.77e-3)" "unprognostic (1.13e-1)" "unprognostic (9.01e-2)" "unprognostic (1.37e-3)" "unprognostic (8.06e-2)" "unprognostic (1.10e-2)" "unprognostic (1.92e-2)" "unprognostic (4.78e-2)" "unprognostic (2.72e-1)" "prognostic favorable (1.40e-5)" 0.0 2.2 3.7 1.0 5.7 0.0 0.0 14.4 6.5 0.3 0.0 7.4 3.2 5.5 0.0 0.0 0.1 1.0 0.0 7.2 0.5 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.3 0.2 0.1 0.0 5.0 2.5 0.0 1.1 0.0 0.0 7.6 2.9 1.5 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.2 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 1.9 0.0 0.4 0.0 0.0 0.7 0.0 0.0 0.0 20.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.2 37.4 0.1 5.8 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.7 5.7 14.4 6.5 7.2 0.5 0.2 0.0 0.1 1.5 0.0 1.5 1.7 0.0 0.0 3.9 0.2 0.5 0.1 0.5 0.0 16.5 0.2 0.1 3.5 0.0 3.4 0.0 0.0 0.0 0.7 43.2 0.0 2.6 1.7 2.2 1.3 4.0 0.0 0.0 199.5 0.2 0.3 0.3 10.2 14.6 0.0 0.0 0.7 0.0 0.0 16.8 160.7 1.8 0.0 0.0 0.3 0.4 0.0 0.2 0.0 3.7 0.0 0.2 1.0 2.0 4.0 2.8 23.0 0.0 0.0 0.4 17.3 0.0 0.1 0.8 0.0 0.1 0.8 0.0 0.1 0.0 0.1 0.8 0.4 0.0 0.7 0.4 PTPRS ENSG00000105426 "Protein tyrosine phosphatase receptor type S" Q13332 19 5158495-5340803 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins" "Cell adhesion" "Heparin-binding, Hydrolase, Protein phosphatase, Receptor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 76.8;Inhibitory neurons: 104.2;Melanocytes: 80.0;Oligodendrocytes: 90.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 89 "plasmacytoid DC: 12.5" "Lineage enriched" "Detected in single" 89 "dendritic cells: 12.5" "Cell line enhanced" "Detected in many" "AN3-CA: 121.8;HaCaT: 124.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054747 Approved "Plasma membrane,Cytosol" "Secreted - unknown location" NA NA 150000000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane, Cytosol" "HPA054747: AB_2682591" "unprognostic (8.14e-2)" "unprognostic (4.59e-3)" "unprognostic (2.57e-2)" "unprognostic (9.20e-2)" "unprognostic (2.15e-1)" "unprognostic (6.96e-3)" "unprognostic (6.85e-2)" "unprognostic (2.36e-1)" "unprognostic (3.12e-3)" "unprognostic (1.86e-1)" "prognostic favorable (1.07e-4)" "unprognostic (1.25e-1)" "prognostic unfavorable (1.70e-4)" "unprognostic (2.80e-1)" "unprognostic (1.45e-1)" "unprognostic (4.05e-1)" "unprognostic (3.46e-2)" 54.7 21.2 34.4 5.0 25.5 1.5 36.2 3.2 30.9 40.2 0.0 25.2 2.6 30.5 2.2 16.5 41.1 13.7 37.0 34.3 10.0 11.2 6.0 26.9 5.5 16.4 16.4 35.8 32.4 9.7 29.1 2.3 17.6 30.5 1.6 5.7 18.6 14.6 14.4 20.6 13.6 8.6 1.6 9.0 23.2 9.9 27.3 4.2 29.4 7.4 4.4 32.0 31.8 34.9 11.3 64.0 56.2 121.8 25.3 20.5 7.4 19.4 22.5 22.8 18.5 0.7 6.2 0.2 44.5 32.2 18.0 124.6 15.1 0.2 10.0 1.5 24.3 0.0 27.2 40.5 11.7 0.0 14.1 21.8 5.4 4.8 0.9 29.4 0.6 7.9 18.5 0.2 9.1 48.0 5.2 12.3 31.7 0.4 27.0 0.0 12.4 0.0 4.7 22.5 43.1 58.9 18.3 3.4 34.6 10.7 22.0 4.8 2.8 20.2 34.3 46.9 23.6 6.2 0.1 36.9 10.5 0.0 44.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.5 0.0 0.0 34.4 25.5 3.2 30.9 34.3 10.0 16.4 16.4 17.6 1.6 27.3 34.9 1.1 6.4 1.1 53.8 3.2 60.9 42.4 16.1 22.2 49.6 3.3 5.5 14.1 27.1 4.9 12.9 2.1 0.7 56.4 0.1 9.8 1.4 3.4 5.4 11.4 9.7 3.0 0.0 76.8 0.9 32.2 51.2 5.1 5.3 0.0 4.0 25.4 20.2 1.7 11.8 104.2 0.0 10.2 0.3 20.0 5.4 46.6 3.4 80.0 15.9 0.8 46.6 0.0 71.9 90.2 0.5 0.0 36.1 6.3 35.0 0.0 2.9 1.7 10.1 13.1 46.4 22.6 7.4 14.8 16.8 36.7 1.0 2.0 2.7 0.4 30.0 PTPRT "KIAA0283, RPTPrho" ENSG00000196090 "Protein tyrosine phosphatase receptor type T" O14522 20 42072752-43189970 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protein phosphatase, Receptor" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 23.9;fallopian tube: 10.8" "Group enriched" "Detected in some" 14 "Excitatory neurons: 500.7;Inhibitory neurons: 700.2;Oligodendrocyte precursor cells: 418.7" "Group enriched" "Detected in many" 5 "breast cancer: 5.1;prostate cancer: 1.9" "Region enhanced" "Detected in many" "cerebral cortex: 23.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "BEWO: 1.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017336, CAB069423" Approved NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 28: BEWO - Transcription regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB069423: AB_1622602, HPA017336: AB_1855943" "unprognostic (7.17e-3)" "unprognostic (1.02e-1)" "unprognostic (5.61e-3)" "unprognostic (1.08e-2)" "unprognostic (5.95e-2)" "unprognostic (3.71e-2)" "unprognostic (1.97e-1)" "unprognostic (1.31e-2)" "unprognostic (6.93e-2)" "unprognostic (2.00e-1)" "unprognostic (1.37e-6)" "unprognostic (3.16e-1)" "unprognostic (1.13e-2)" "unprognostic (1.81e-1)" "unprognostic (3.17e-1)" "unprognostic (1.10e-1)" "unprognostic (1.17e-1)" 0.1 0.2 10.1 0.1 10.7 0.0 2.7 0.0 23.9 0.6 0.0 0.1 0.5 0.0 0.2 0.0 10.8 0.1 0.2 7.4 0.0 0.1 0.2 1.0 0.4 0.1 0.0 0.0 0.4 0.0 3.0 2.8 0.0 0.2 0.0 3.6 1.0 2.6 0.0 0.4 0.3 0.0 0.0 0.1 0.8 1.6 0.0 6.3 0.0 0.1 0.4 0.0 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.1 10.7 0.0 23.9 7.4 0.0 0.1 0.0 0.0 0.0 0.0 5.0 0.4 0.0 1.1 13.1 0.0 0.9 0.0 0.0 0.0 36.2 2.6 6.9 1.5 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.4 3.2 0.1 0.2 0.0 0.0 500.7 0.0 0.0 1.2 0.0 0.2 0.0 3.3 6.4 0.2 0.2 5.0 700.2 0.0 0.0 0.3 0.3 12.6 0.0 0.1 0.0 8.4 0.0 10.3 0.0 418.7 8.3 0.0 0.0 0.0 0.0 0.1 0.0 0.2 18.5 2.1 0.0 0.5 0.2 0.0 1.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 PTPRU "FMI, hPTP-J, PCP-2, PTP, PTPRO" ENSG00000060656 "Protein tyrosine phosphatase receptor type U" Q92729 1 29236516-29326813 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Cell adhesion, Differentiation" "Hydrolase, Protein phosphatase, Receptor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 22.1;Respiratory ciliated cells: 24.3;Rod photoreceptor cells: 42.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 95.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB011476, HPA039832" Approved NA NA "Cluster 57: Non-specific - Angiogenesis" "Cluster 28: BEWO - Transcription regulation" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "CAB011476: AB_442989, HPA039832: AB_10793923" "unprognostic (7.81e-2)" "unprognostic (1.70e-1)" "unprognostic (2.15e-3)" "unprognostic (6.13e-2)" "prognostic unfavorable (7.92e-4)" "prognostic unfavorable (8.32e-4)" "unprognostic (3.17e-1)" "unprognostic (1.83e-2)" "unprognostic (1.13e-1)" "unprognostic (4.55e-3)" "unprognostic (3.39e-3)" "unprognostic (6.83e-2)" "unprognostic (1.19e-2)" "unprognostic (6.82e-2)" "unprognostic (4.92e-2)" "unprognostic (3.34e-1)" "unprognostic (2.05e-1)" 7.1 2.1 12.6 1.1 18.3 0.1 6.9 6.4 16.1 31.1 6.1 5.3 0.7 11.9 3.3 4.3 11.5 4.8 8.7 14.4 10.0 4.9 9.1 9.9 0.6 29.1 18.9 13.0 11.1 9.2 10.2 11.5 28.0 14.0 1.4 18.8 14.6 12.9 17.5 10.1 2.4 1.9 6.3 2.1 5.9 4.0 9.7 1.0 5.2 9.9 1.3 12.3 12.2 11.1 8.1 10.8 0.6 1.6 28.7 1.0 95.7 8.4 7.4 0.3 0.5 9.4 34.7 1.4 16.2 1.6 1.0 42.3 38.5 27.1 0.1 0.5 19.7 1.7 12.1 39.8 12.1 0.0 1.7 13.3 14.4 0.0 2.5 11.3 0.2 4.7 0.3 1.3 7.6 13.2 0.5 0.2 15.8 15.9 4.9 0.0 11.3 0.5 11.7 39.4 32.3 42.0 8.5 26.3 5.8 6.6 15.6 1.8 7.1 1.4 9.3 2.6 1.2 0.8 1.1 0.1 18.8 1.9 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.6 18.3 6.4 16.1 14.4 10.0 29.1 18.9 28.0 6.3 9.7 11.1 1.0 9.6 13.6 0.7 0.1 1.5 6.7 22.1 1.8 5.3 4.8 5.6 5.2 5.7 20.2 5.5 12.5 18.7 0.5 0.3 0.0 6.2 1.3 8.6 9.4 1.3 0.0 0.0 12.1 2.7 10.5 4.6 0.0 10.1 1.3 0.7 1.8 5.3 2.6 0.0 8.0 0.2 6.1 0.6 1.1 1.2 4.7 0.4 8.8 3.7 0.0 16.7 0.0 8.5 4.4 7.3 0.0 7.2 1.2 6.5 0.0 0.3 24.3 42.6 6.6 5.5 4.1 2.1 6.4 0.2 0.6 9.0 0.6 0.0 0.2 10.0 PTPRZ1 "phosphacan, PTP18, PTPRZ, PTPZ, RPTPB" ENSG00000106278 "Protein tyrosine phosphatase receptor type Z1" P23471 7 121873089-122062036 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 88.4;skin 1: 31.9" "Cell type enriched" "Detected in many" 4 "Oligodendrocyte precursor cells: 2714.3" "Cancer enriched" "Detected in many" 14 "glioma: 175.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 9 "AF22: 425.5;NTERA-2: 126.3;WM-115: 193.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015103 Enhanced Approved Vesicles,Cytosol "Secreted in brain" NA NA 3400000 "Cluster 27: Brain & Skin - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 68: Oligodendrocytes - Mixed function" Cytosol Vesicles "HPA015103: AB_1855946" "unprognostic (8.49e-4)" "unprognostic (3.96e-3)" "unprognostic (4.11e-2)" "unprognostic (1.37e-1)" "unprognostic (9.18e-2)" "unprognostic (2.41e-2)" "unprognostic (8.30e-3)" "unprognostic (3.78e-2)" "unprognostic (1.57e-1)" "unprognostic (2.53e-1)" "unprognostic (9.17e-4)" "unprognostic (1.83e-1)" "unprognostic (8.72e-6)" "unprognostic (2.00e-1)" "unprognostic (2.16e-1)" "unprognostic (8.77e-2)" "prognostic unfavorable (9.36e-4)" 1.6 1.6 66.0 1.2 64.2 0.0 4.0 57.2 88.4 1.8 21.5 4.4 0.6 0.1 0.8 7.9 0.3 0.7 1.3 64.0 64.1 0.1 0.1 1.2 0.0 60.9 62.9 0.7 2.7 0.0 2.3 0.2 62.4 1.0 1.1 19.0 3.4 0.7 0.1 31.9 1.0 1.3 63.7 1.0 13.8 0.3 58.6 0.2 0.1 0.3 2.6 0.9 2.3 72.4 0.1 0.0 425.5 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 12.3 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 2.1 0.0 27.7 0.0 0.0 0.0 0.0 1.0 0.0 0.1 0.0 0.0 126.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.8 0.0 0.0 0.0 5.4 15.2 0.1 0.0 0.0 0.1 0.0 0.0 0.7 10.9 5.6 0.0 0.6 0.0 193.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 66.0 64.2 57.2 88.4 64.0 64.1 60.9 62.9 62.4 63.7 58.6 72.4 0.1 0.0 1.5 625.2 0.2 25.2 8.6 82.2 44.9 18.3 5.6 12.2 1.3 0.0 39.7 0.0 4.2 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.4 0.3 0.0 0.0 37.7 0.7 0.1 1.3 9.2 0.0 0.0 10.1 0.0 0.0 0.1 65.6 72.0 0.0 0.0 0.0 1.6 0.7 0.3 0.1 19.6 22.5 0.0 90.4 0.0 2714.3 3.6 0.9 0.3 0.0 1.2 1.8 0.0 0.1 16.9 6.6 0.0 1.2 1.7 0.1 1.6 14.8 21.5 0.3 0.2 0.5 0.0 7.8 RET "CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51" ENSG00000165731 "Ret proto-oncogene" P07949 10 43077064-43130351 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Hirschsprung disease, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "adrenal gland: 20.8;brain: 27.3;parathyroid gland: 31.8" "Group enriched" "Detected in some" 4 "Horizontal cells: 79.1;Ionocytes: 26.4;Skeletal myocytes: 23.1" "Cancer enhanced" "Detected in many" "breast cancer: 11.0" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "MCF7: 74.6;NB-4: 42.2;SH-SY5Y: 329.3;THP-1: 95.9" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "midbrain: 53.3;spinal cord: 19.4" "CAB002581, HPA008356, HPA008495" Approved Supported Approved "Golgi apparatus,Plasma membrane,Cytosol" No NA 2100000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 50: Fibroblasts - ECM organization" "Golgi apparatus, Cytosol" "Plasma membrane" "CAB002581: AB_563673, HPA008356: AB_1847232, HPA008495: " "unprognostic (7.94e-2)" "unprognostic (3.68e-2)" "unprognostic (4.49e-1)" "prognostic unfavorable (5.02e-4)" "unprognostic (1.15e-1)" "unprognostic (9.13e-4)" "unprognostic (1.27e-2)" "unprognostic (3.62e-2)" "unprognostic (2.86e-1)" "unprognostic (2.01e-1)" "unprognostic (1.54e-3)" "unprognostic (4.43e-1)" "unprognostic (9.35e-5)" "unprognostic (1.64e-3)" "unprognostic (8.28e-2)" "unprognostic (3.67e-3)" "unprognostic (2.02e-2)" 1.8 20.8 1.0 1.3 0.9 0.4 1.1 5.1 5.6 1.0 0.2 3.4 1.4 0.6 0.3 0.4 0.5 0.6 2.2 0.3 5.5 0.9 3.0 0.4 0.6 14.4 27.3 0.4 1.3 31.8 5.3 0.5 12.0 1.8 1.4 4.7 5.1 2.0 5.9 0.9 1.4 1.0 4.8 0.2 2.2 2.7 7.6 1.6 0.8 3.1 0.2 0.6 1.4 5.8 0.1 0.4 0.1 1.7 0.0 0.0 0.1 0.7 0.2 0.4 0.1 0.0 0.0 0.0 0.1 0.0 0.6 0.0 5.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 7.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 74.6 0.0 42.2 7.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 4.7 329.3 0.1 0.0 0.1 0.5 4.1 95.9 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.9 0.7 0.1 0.0 1.0 0.9 5.1 5.6 0.3 5.5 14.4 27.3 12.0 4.8 7.6 5.8 0.4 0.0 0.5 1.6 0.0 0.3 0.8 0.0 0.0 1.7 6.0 0.5 2.1 0.0 0.0 0.0 0.0 0.0 2.1 0.2 0.0 0.0 1.5 0.0 0.3 1.1 0.0 0.0 4.2 0.2 2.3 6.8 0.0 0.0 1.3 0.5 0.0 1.2 0.1 79.1 8.6 1.9 26.4 0.0 0.6 1.5 0.3 0.5 0.0 1.0 0.0 0.8 0.0 1.0 0.6 0.0 0.0 0.0 0.0 0.9 0.0 0.1 0.8 1.7 0.0 23.1 1.2 1.1 4.7 0.0 0.6 0.0 0.2 0.3 0.2 0.1 ROR1 NTRKR1 ENSG00000185483 "Receptor tyrosine kinase like orphan receptor 1" Q01973 1 63774017-64181498 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Wnt signaling pathway" "Kinase, Receptor, Transferase" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "parathyroid gland: 26.9" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 51.3;Astrocytes: 81.0;Inhibitory neurons: 69.7;Microglial cells: 36.5;Oligodendrocytes: 109.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 40.5;ASC TERT1: 50.3;CACO-2: 36.8;HHSteC: 38.3;HSkMC: 41.6;NTERA-2: 43.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "Intracellular and membrane" NA NA 7700000 "Cluster 40: NK-cells - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (5.15e-2)" "unprognostic (1.19e-2)" "unprognostic (3.65e-2)" "unprognostic (1.03e-2)" "unprognostic (6.24e-2)" "unprognostic (1.61e-1)" "unprognostic (7.11e-3)" "unprognostic (1.41e-1)" "unprognostic (4.06e-1)" "unprognostic (3.84e-1)" "unprognostic (3.20e-2)" "unprognostic (2.02e-2)" "unprognostic (3.64e-3)" "unprognostic (1.48e-2)" "unprognostic (1.52e-1)" "unprognostic (5.87e-2)" "unprognostic (5.15e-2)" 4.4 1.1 0.6 2.2 1.4 0.4 3.7 3.0 0.8 7.5 4.6 4.5 2.2 7.1 1.4 5.2 2.5 5.2 7.5 0.7 0.6 2.3 0.5 7.0 1.2 0.7 0.9 8.3 5.5 26.9 0.5 3.1 0.5 5.4 4.0 1.5 1.2 6.4 2.3 2.3 1.7 7.7 0.3 3.2 6.4 1.5 1.2 2.5 1.4 1.6 1.1 4.2 2.3 1.1 15.5 12.2 5.9 0.8 40.5 50.3 4.0 2.9 8.3 1.6 4.3 36.8 4.9 0.3 6.6 7.2 2.9 3.2 0.1 2.9 1.1 0.0 3.7 0.0 1.6 0.5 38.3 0.0 0.0 41.6 10.9 21.7 25.2 8.4 0.7 0.5 0.0 0.3 11.0 0.2 0.2 0.1 43.0 11.3 6.1 0.2 0.2 9.8 8.7 0.3 3.4 13.6 0.8 0.2 6.4 19.9 0.1 0.0 8.4 3.3 5.7 23.0 6.2 0.0 0.0 0.0 0.4 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.2 0.0 0.0 0.6 1.4 3.0 0.8 0.7 0.6 0.7 0.9 0.5 0.3 1.2 1.1 1.1 51.3 10.5 81.0 1.8 3.8 2.2 0.5 29.0 4.7 3.0 2.0 11.4 1.5 1.3 1.8 0.0 0.2 0.1 1.3 0.0 5.6 9.6 1.2 9.2 1.8 21.5 0.0 11.6 15.2 1.0 14.5 16.8 1.9 0.0 1.1 0.7 0.0 7.6 0.0 69.7 2.2 2.0 0.6 4.9 8.1 27.7 0.5 3.6 36.5 0.0 5.3 0.0 3.5 109.9 15.3 0.8 14.7 0.1 1.4 0.0 3.4 0.8 0.3 6.6 6.8 8.5 1.4 1.8 11.5 4.5 0.3 0.2 0.3 3.3 0.8 ROR2 "BDB, BDB1, NTRKR2" ENSG00000169071 "Receptor tyrosine kinase like orphan receptor 2" Q01974 9 91563091-91950228 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Wnt signaling pathway" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 18.4;Endometrial stromal cells: 19.3;Fibroblasts: 14.4;Inhibitory neurons: 18.6;Microglial cells: 15.9;Oligodendrocyte precursor cells: 27.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 6 "MAIT T-cell: 1.0" "Lineage enriched" "Detected in single" 6 "T-cells: 1.0" "Cell line enhanced" "Detected in many" "AF22: 24.5;HHSteC: 63.1;HSkMC: 52.2;U-266/70: 38.3;U-266/84: 27.5" "Low region specificity" "Detected in single" "Group enriched" "Detected in some" 7 "cerebellum: 7.2;spinal cord: 3.7" HPA021868 Uncertain NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 29: U-266 - Adaptive immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA021868: AB_1856406" "unprognostic (9.38e-3)" "unprognostic (4.69e-1)" "unprognostic (2.26e-1)" "unprognostic (8.48e-3)" "unprognostic (1.23e-1)" "unprognostic (2.38e-1)" "unprognostic (2.06e-1)" "unprognostic (1.31e-1)" "unprognostic (8.03e-2)" "unprognostic (2.03e-1)" "unprognostic (5.76e-2)" "unprognostic (2.66e-1)" "prognostic unfavorable (9.86e-7)" "unprognostic (2.16e-3)" "unprognostic (9.13e-2)" "prognostic unfavorable (4.28e-8)" "unprognostic (1.25e-2)" 6.9 5.7 0.8 3.9 0.6 0.1 4.4 0.4 0.5 18.7 28.2 32.7 2.2 23.7 1.5 8.2 11.6 8.6 11.1 1.4 0.8 1.4 0.5 5.5 0.5 1.7 2.1 13.9 1.6 16.6 1.6 3.5 0.9 13.9 2.2 1.0 1.6 13.3 0.3 4.2 7.7 11.0 1.2 3.3 12.8 3.4 1.2 3.0 5.6 0.7 1.0 17.5 10.6 0.7 0.0 0.2 24.5 0.0 5.3 0.5 6.8 0.4 6.3 4.0 7.8 0.0 0.0 0.0 0.1 0.8 3.9 0.2 5.2 0.0 1.7 0.0 4.2 0.0 18.3 0.0 63.1 0.0 0.0 52.2 0.0 5.6 0.0 0.0 0.0 0.2 14.7 0.0 0.0 0.4 0.1 3.6 3.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 7.2 0.6 0.0 0.0 5.0 14.8 0.0 0.0 0.0 4.8 2.0 0.0 38.3 27.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.6 0.4 0.5 1.4 0.8 1.7 2.1 0.9 1.2 1.2 0.7 0.3 0.0 0.0 1.6 0.1 3.1 11.3 0.9 1.2 1.4 3.7 3.0 8.2 1.5 0.2 0.0 0.0 0.4 0.0 0.5 0.0 2.5 4.5 18.4 19.3 1.4 3.0 0.0 1.4 1.5 0.2 14.4 2.6 7.5 1.3 0.1 0.4 0.0 0.8 0.0 18.6 2.8 0.0 0.0 4.8 8.6 5.9 0.4 5.4 15.9 1.6 7.4 0.0 27.6 0.4 0.6 1.6 9.1 0.1 8.6 0.0 0.0 0.2 0.5 6.6 0.0 2.9 2.3 14.3 0.1 2.3 0.4 0.7 0.4 0.8 5.3 ROS1 "c-ros-1, MCF3, ROS" ENSG00000047936 "ROS proto-oncogene 1, receptor tyrosine kinase" P08922 6 117287353-117425942 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 18 "epididymis: 58.6;lung: 31.7" "Cell type enriched" "Detected in some" 4 "Alveolar cells type 2: 78.5" "Cancer enriched" "Detected in some" 13 "lung cancer: 6.9" "Region enriched" "Detected in single" 4 "cerebral cortex: 2.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "GAMG: 19.3;HSkMC: 10.1;hTCEpi: 21.7;LHCN-M2: 14.9" "Not detected" "Not detected" "Not detected" "Not detected" "HPA049098, HPA072424" Uncertain Approved Vesicles NA NA "Cluster 30: Epididymis - Antimicrobial activity" "Cluster 30: Epithelial cell lines - Translation" "Cluster 11: Alveolar cells - Smell perception" Vesicles "HPA049098: AB_2680628, HPA072424: AB_2686519" "unprognostic (8.18e-2)" "unprognostic (4.64e-3)" "unprognostic (1.60e-1)" "unprognostic (2.37e-2)" "unprognostic (7.57e-2)" "unprognostic (2.05e-2)" "unprognostic (1.57e-1)" "unprognostic (1.79e-1)" "unprognostic (2.79e-2)" "unprognostic (1.00e-2)" "unprognostic (2.42e-1)" "unprognostic (5.20e-2)" "unprognostic (1.56e-12)" "unprognostic (1.09e-2)" "unprognostic (2.81e-1)" "unprognostic (1.91e-1)" "unprognostic (2.12e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.2 0.0 0.4 0.0 0.0 58.6 0.0 0.1 0.0 0.0 0.6 0.0 0.3 0.1 31.7 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.4 0.0 0.0 0.4 0.0 0.0 2.2 0.4 0.3 0.2 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.3 0.3 0.0 0.0 0.1 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 10.1 21.7 0.2 1.9 0.0 0.0 0.0 0.0 0.0 14.9 0.0 0.0 0.2 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 2.0 0.0 3.1 1.7 0.2 2.1 0.0 0.0 0.0 1.9 3.5 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 16.0 78.5 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.6 0.0 0.8 0.0 3.7 0.0 0.0 0.0 0.0 0.3 0.0 0.0 1.3 1.8 0.2 0.0 0.0 0.0 17.8 0.0 0.0 0.2 0.0 1.5 1.3 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 1.3 0.0 0.1 0.0 1.0 0.0 0.0 0.0 0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 RYK "D3S3195, JTK5, JTK5A, RYK1" ENSG00000163785 "Receptor like tyrosine kinase" P34925 3 134065303-134250859 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Wnt signaling pathway" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Granulosa cells: 121.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034117, HPA045503, HPA075430" Uncertain Approved "Golgi apparatus,Cytosol" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 89: Fibroblasts - ECM organization" "Cluster 30: Epithelial cell lines - Translation" "Cluster 40: Granulosa cells - Unknown function" "Golgi apparatus" Cytosol "CAB034117: AB_2183048, HPA045503: AB_2679353, HPA075430: AB_2732293" "unprognostic (7.84e-2)" "unprognostic (5.82e-2)" "unprognostic (2.22e-2)" "unprognostic (2.34e-2)" "unprognostic (2.21e-1)" "unprognostic (1.09e-1)" "prognostic unfavorable (2.60e-4)" "unprognostic (2.60e-2)" "unprognostic (6.59e-2)" "unprognostic (1.62e-1)" "unprognostic (1.07e-3)" "unprognostic (9.66e-2)" "unprognostic (2.42e-2)" "unprognostic (5.54e-2)" "unprognostic (3.13e-1)" "unprognostic (3.43e-1)" "unprognostic (2.85e-2)" 31.8 25.2 15.7 15.7 16.2 17.1 42.8 15.4 19.8 40.2 19.9 34.5 20.1 46.1 40.0 29.6 33.4 24.3 30.3 14.5 15.3 25.4 22.3 25.3 18.9 15.9 15.6 82.1 24.5 29.7 17.0 36.6 15.5 36.3 26.2 15.9 26.9 43.9 25.3 34.7 21.4 40.6 16.3 22.9 23.2 47.0 16.5 21.2 40.9 32.2 20.5 34.7 32.6 16.4 78.8 20.6 63.3 48.7 79.8 84.4 48.8 51.0 117.7 66.4 74.2 65.6 58.8 15.3 82.4 63.1 63.7 71.6 45.5 64.3 94.5 25.9 20.5 40.6 22.4 42.4 62.2 20.0 34.4 56.1 74.0 41.2 82.2 72.5 56.5 26.4 14.5 7.5 66.0 37.6 28.0 25.9 53.4 65.2 24.3 13.7 48.4 32.4 54.5 57.3 31.0 45.6 61.7 44.5 79.1 40.5 55.7 35.8 42.1 54.8 49.6 57.8 41.8 3.1 4.2 8.3 34.8 33.1 39.6 4.6 0.8 1.6 1.1 0.8 1.3 0.6 2.0 1.3 0.3 1.2 1.9 1.5 0.3 1.6 0.8 0.0 0.5 0.5 15.7 16.2 15.4 19.8 14.5 15.3 15.9 15.6 15.5 16.3 16.5 16.4 62.5 12.8 27.9 31.6 20.6 41.3 36.6 26.3 39.3 23.1 45.4 37.2 34.9 18.6 23.7 44.1 29.2 19.4 23.1 15.9 0.0 15.9 16.2 27.6 41.7 31.0 13.9 13.2 69.5 21.1 14.7 41.3 15.8 32.7 17.7 121.2 40.7 24.1 11.3 13.5 59.7 20.9 12.2 18.6 21.6 7.4 33.2 16.1 14.2 65.6 12.8 26.8 13.4 65.9 57.9 21.7 19.7 32.7 12.9 42.8 15.4 10.5 13.9 39.8 46.0 33.8 38.1 24.6 40.9 33.7 38.1 10.8 18.4 50.8 22.2 38.9 SPRYD3 FLJ14800 ENSG00000167778 "SPRY domain containing 3" Q8NCJ5 12 53064316-53079404 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039426, HPA039685" Enhanced Approved "Nucleoplasm,Vesicles,Plasma membrane,Actin filaments,Cytosol" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 50: Fibroblasts - ECM organization" "Nucleoplasm, Cytosol" "Vesicles, Plasma membrane, Actin filaments" "HPA039426: AB_10673358, HPA039685: AB_2676623" "unprognostic (7.73e-3)" "unprognostic (6.55e-2)" "unprognostic (1.37e-2)" "unprognostic (5.05e-3)" "unprognostic (1.52e-2)" "prognostic unfavorable (9.46e-4)" "unprognostic (1.27e-3)" "unprognostic (2.58e-1)" "unprognostic (1.83e-2)" "unprognostic (1.43e-2)" "unprognostic (2.64e-2)" "unprognostic (3.14e-2)" "prognostic favorable (1.78e-15)" "unprognostic (9.82e-2)" "unprognostic (5.27e-2)" "unprognostic (7.44e-3)" "unprognostic (1.41e-1)" 32.2 29.2 70.6 18.4 77.9 6.4 30.2 35.6 84.2 33.6 38.1 32.8 18.9 38.1 36.2 31.7 45.1 20.4 42.4 79.9 60.4 29.5 22.1 23.6 17.4 61.7 55.1 43.5 50.0 43.3 60.7 14.0 61.5 34.5 17.0 39.3 43.9 40.6 21.2 27.0 23.4 31.6 43.8 24.3 35.8 11.5 58.0 13.7 34.6 23.1 20.6 36.5 30.7 67.9 28.4 43.0 5.6 11.5 45.4 22.4 7.3 42.6 22.2 16.1 10.1 7.4 23.8 18.6 34.2 53.5 19.2 26.0 7.6 32.9 10.5 19.4 11.3 11.5 25.5 16.9 34.0 22.3 20.1 20.2 51.6 23.1 34.9 31.6 33.5 9.3 10.4 45.3 28.5 62.3 16.3 11.7 3.2 23.1 30.8 7.1 9.5 38.4 20.6 22.3 9.4 8.9 37.3 34.6 18.1 3.0 31.8 16.7 46.4 18.1 17.9 40.9 29.0 24.7 24.1 5.4 53.8 19.5 22.4 29.9 16.7 47.5 32.7 28.9 30.9 14.6 22.4 26.9 15.5 11.3 18.8 22.7 25.8 17.0 32.8 7.4 13.5 28.9 70.6 77.9 35.6 84.2 79.9 60.4 61.7 55.1 61.5 43.8 58.0 67.9 13.4 3.2 10.1 4.9 13.3 5.7 19.5 12.0 13.1 46.4 11.3 8.8 20.4 17.2 10.4 18.4 8.4 6.2 8.8 9.1 11.7 30.4 0.9 21.2 10.9 17.1 11.5 2.1 14.4 36.5 14.6 22.9 15.8 16.1 10.1 5.1 18.9 9.1 11.8 43.7 13.5 13.8 10.2 11.7 5.7 2.7 16.1 10.3 10.6 3.7 15.0 38.5 16.5 4.5 5.6 28.6 9.3 33.1 19.1 20.8 10.7 15.6 18.2 23.8 19.7 11.1 20.0 4.5 3.9 12.0 9.5 4.2 14.9 5.1 7.9 16.4 SRC "ASV, c-src, SRC1" ENSG00000197122 "SRC proto-oncogene, non-receptor tyrosine kinase" P12931 20 37344685-37406050 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters" "Cell adhesion, Cell cycle, Host-virus interaction, Immunity" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 42.0;Gastric mucus-secreting cells: 43.8;Langerhans cells: 46.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "intermediate monocyte: 2.4;non-classical monocyte: 2.3" "Group enriched" "Detected in many" 6 "dendritic cells: 1.4;monocytes: 2.4" "Cell line enhanced" "Detected in many" "A549: 110.8;HBEC3-KT: 102.6;RT4: 106.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004023, HPA030875" Approved Supported "Nucleoplasm,Plasma membrane,Cell Junctions,Cytosol" NA NA 3200000 "Cluster 51: Monocytes - Innate immune response" "Cluster 71: Testis - DNA repair" "Cluster 15: RT4 - Unknown function" "Cluster 27: Mucus-secreting cells - Mucin production" "Plasma membrane, Cell Junctions" "Nucleoplasm, Cytosol" "CAB004023: AB_2106059, HPA030875: AB_2673640" "unprognostic (5.58e-2)" "unprognostic (9.83e-2)" "unprognostic (3.56e-1)" "unprognostic (4.54e-3)" "unprognostic (1.52e-1)" "unprognostic (1.54e-2)" "prognostic unfavorable (4.90e-5)" "unprognostic (3.89e-2)" "unprognostic (7.04e-2)" "unprognostic (8.13e-2)" "unprognostic (1.54e-2)" "prognostic unfavorable (1.63e-4)" "prognostic unfavorable (1.22e-4)" "unprognostic (2.33e-2)" "unprognostic (4.72e-2)" "unprognostic (3.65e-2)" "prognostic favorable (5.22e-5)" 9.7 25.3 5.7 13.3 5.2 8.4 10.1 0.4 6.2 25.1 1.5 30.3 39.8 31.9 3.2 26.1 23.8 27.9 8.8 6.4 5.5 21.4 4.3 16.1 6.3 2.6 3.4 23.6 30.8 11.1 15.9 8.1 2.2 30.8 17.1 5.5 11.8 27.4 2.4 13.0 38.8 17.2 1.7 14.2 39.9 25.2 5.0 6.1 9.8 1.5 8.1 35.6 24.6 3.0 24.6 110.8 24.9 22.6 9.3 14.7 51.6 22.0 18.9 26.3 16.6 41.9 21.5 0.7 13.4 40.2 29.9 43.5 15.1 102.6 10.3 0.1 13.7 6.2 3.9 65.9 22.0 0.3 9.3 15.7 34.2 17.3 22.8 29.4 24.3 14.2 0.6 0.2 4.4 16.7 6.0 0.8 11.7 67.3 98.8 26.5 6.6 0.7 11.0 106.3 23.1 83.6 25.0 34.5 27.2 19.1 31.1 9.0 35.8 31.4 20.9 11.7 20.1 0.3 0.8 0.3 22.1 0.1 24.0 0.0 1.6 0.0 0.0 2.4 0.0 0.1 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.3 2.3 1.4 0.0 1.0 5.7 5.2 0.4 6.2 6.4 5.5 2.6 3.4 2.2 1.7 5.0 3.0 1.0 3.2 1.7 3.3 4.1 8.2 12.5 9.5 10.8 6.5 6.2 7.5 2.2 18.6 4.7 12.9 2.1 2.3 4.9 42.0 1.9 12.2 1.8 6.4 10.7 1.4 16.8 0.4 9.5 18.7 8.3 7.2 43.8 12.4 0.0 14.8 1.1 1.6 5.7 3.3 9.1 29.2 8.2 9.4 46.3 3.3 10.8 22.8 1.8 9.4 9.7 4.4 1.0 9.0 0.6 39.1 19.2 17.3 4.3 18.0 36.7 9.3 5.6 5.2 13.1 1.8 6.7 0.3 1.1 11.2 9.1 2.3 1.0 2.9 16.9 36.6 SRMS "C20orf148, dJ697K14.1, PTK70, SRM" ENSG00000125508 "Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites" Q9H3Y6 20 63540810-63547504 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "stomach 1: 1.6" "Cell type enriched" "Detected in single" 4 "Gastric mucus-secreting cells: 3.6" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CAPAN-2: 3.3;MCF7: 3.0;OE19: 4.4;RT4: 6.0" "Not detected" "Not detected" "Not detected" "Not detected" "CAB044668, CAB044669, HPA073987" Uncertain Approved "Intermediate filaments,Actin filaments,Cytosol" No NA "Cluster 24: Salivary gland - Salivary secretion" "Cluster 21: OE19 - Mitochondria" "Cluster 43: Cardiomyocytes - Nuclear processes" "Intermediate filaments" "Actin filaments, Cytosol" "CAB044668: AB_10609403, CAB044669: AB_10608235, HPA073987: AB_2686650" "unprognostic (2.26e-2)" "unprognostic (1.26e-2)" "unprognostic (2.52e-3)" "unprognostic (8.32e-2)" "unprognostic (2.62e-1)" "unprognostic (5.47e-3)" "unprognostic (1.65e-1)" "unprognostic (2.28e-1)" "unprognostic (9.63e-2)" "unprognostic (6.48e-3)" "unprognostic (7.28e-3)" "unprognostic (1.46e-1)" "unprognostic (1.73e-3)" "unprognostic (2.58e-3)" "unprognostic (4.75e-2)" "unprognostic (4.97e-2)" "unprognostic (2.54e-3)" 0.0 0.0 0.1 0.2 0.1 0.1 0.4 0.6 0.2 0.0 0.0 0.7 0.2 0.0 0.7 0.1 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 1.0 0.0 0.0 0.0 0.1 0.8 0.0 0.0 0.8 0.0 0.0 0.4 0.2 0.0 0.1 0.9 1.6 0.2 0.1 0.0 0.1 0.0 0.1 0.3 0.0 0.6 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 3.3 0.1 1.3 0.0 0.0 1.5 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 3.0 0.0 0.1 0.0 4.4 0.4 0.0 0.1 0.0 0.0 6.0 0.4 0.5 0.1 1.2 0.2 0.0 1.5 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.6 0.2 0.0 0.0 0.1 0.0 0.1 0.1 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SSH1 "KIAA1298, SSH1L" ENSG00000084112 "Slingshot protein phosphatase 1" Q8WYL5 12 108778191-108857590 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Actin-binding, Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "WM-115: 63.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019845 Uncertain Uncertain "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 17: WM-115 - Nervous system development" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Plasma membrane" "Nucleoplasm, Cytosol" "HPA019845: AB_1857497" "unprognostic (1.18e-3)" "unprognostic (3.00e-1)" "unprognostic (2.49e-1)" "unprognostic (2.70e-2)" "unprognostic (9.40e-2)" "unprognostic (7.45e-2)" "prognostic unfavorable (5.80e-5)" "unprognostic (3.28e-2)" "unprognostic (3.69e-2)" "unprognostic (1.72e-3)" "unprognostic (7.12e-2)" "unprognostic (3.42e-1)" "unprognostic (1.71e-2)" "unprognostic (1.41e-1)" "unprognostic (8.66e-2)" "unprognostic (9.55e-2)" "unprognostic (6.22e-2)" 6.6 5.1 5.6 5.1 5.1 7.9 5.0 9.2 5.5 5.8 7.2 7.2 2.9 5.9 4.0 5.5 5.3 5.3 7.8 5.7 5.3 6.7 5.5 11.8 4.1 5.8 5.7 5.0 4.3 5.4 5.2 5.2 5.2 5.2 4.1 5.7 3.9 4.8 11.9 4.6 5.1 5.5 5.0 7.5 4.9 3.5 5.1 3.6 5.3 6.5 4.2 6.0 5.2 5.1 9.9 12.7 8.2 6.4 15.1 12.8 7.2 12.8 26.1 11.0 9.7 6.4 4.6 4.9 8.7 29.0 18.8 9.8 4.9 20.7 8.9 9.9 4.8 11.3 6.0 4.0 8.1 5.8 28.4 17.7 7.0 10.0 22.0 27.1 10.3 5.6 2.5 3.6 29.1 5.4 6.6 8.0 5.8 3.8 10.3 4.6 9.8 6.1 4.5 17.1 6.1 8.1 11.0 2.8 24.2 11.2 3.9 4.8 8.1 19.6 8.4 11.9 7.1 7.3 7.0 5.6 10.3 4.5 63.1 1.8 0.9 2.0 1.0 1.5 0.9 0.6 0.5 0.9 0.6 0.6 0.4 0.5 2.1 0.7 1.2 0.7 0.6 0.5 5.6 5.1 9.2 5.5 5.7 5.3 5.8 5.7 5.2 5.0 5.1 5.1 34.5 9.6 16.1 26.1 6.3 9.4 20.8 23.6 19.4 12.9 6.9 6.6 25.1 11.5 12.7 14.7 16.7 6.0 18.5 8.2 5.9 8.4 2.2 10.8 17.1 52.2 5.4 7.8 27.3 8.2 4.4 14.0 13.7 16.9 20.8 12.0 29.3 15.2 12.3 11.8 35.4 5.4 0.0 23.0 20.3 5.0 6.5 21.1 12.4 55.3 33.7 7.8 14.4 14.1 14.8 12.3 2.4 12.8 13.1 21.8 4.0 6.7 9.0 19.1 6.6 17.8 18.1 1.4 7.7 13.2 8.9 2.3 17.9 7.6 7.8 13.9 SSH2 KIAA1725 ENSG00000141298 "Slingshot protein phosphatase 2" Q76I76 17 29625938-29930276 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Actin-binding, Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 91.5" "Cell type enhanced" "Detected in all" "Excitatory neurons: 269.0;Inhibitory neurons: 255.2;Microglial cells: 254.8;Oligodendrocytes: 547.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "eosinophil: 134.8" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017189, HPA057099" Uncertain NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 59: Non-specific - Transcription" "CAB017189: , HPA057099: AB_2683336" "unprognostic (1.45e-1)" "unprognostic (1.57e-1)" "unprognostic (3.56e-2)" "unprognostic (1.27e-2)" "unprognostic (1.44e-1)" "unprognostic (1.53e-1)" "unprognostic (3.00e-3)" "unprognostic (7.05e-2)" "unprognostic (1.14e-1)" "unprognostic (6.80e-2)" "unprognostic (9.80e-3)" "unprognostic (7.52e-2)" "unprognostic (1.48e-2)" "unprognostic (8.28e-2)" "unprognostic (7.70e-2)" "unprognostic (2.74e-1)" "unprognostic (1.86e-1)" 15.6 9.5 11.7 22.5 13.1 62.8 10.7 12.8 16.3 7.1 3.6 13.0 8.3 7.3 8.9 12.7 8.2 8.9 19.4 13.1 23.2 15.1 13.6 21.4 29.0 19.0 14.4 3.9 14.6 6.2 7.1 10.4 18.5 6.3 10.9 8.1 10.7 4.5 91.5 14.4 20.7 7.9 11.4 28.3 15.5 28.2 16.3 28.9 13.9 35.6 24.8 9.0 8.7 24.5 25.8 19.0 12.6 10.8 36.1 24.7 8.8 12.3 12.9 19.6 19.2 12.9 9.0 22.1 18.8 14.1 12.6 31.0 14.8 17.1 22.4 7.1 28.1 14.9 21.2 17.4 16.6 16.7 30.7 30.4 12.3 20.6 13.4 9.7 47.3 36.2 9.9 16.8 13.7 7.3 74.9 15.5 9.4 9.3 11.5 37.9 31.9 37.0 35.7 20.3 20.6 32.3 18.0 18.6 36.6 16.3 12.6 19.4 25.6 12.6 26.3 23.5 16.1 26.9 20.0 53.8 16.4 13.1 12.3 47.2 15.2 134.8 10.4 20.2 8.5 21.3 11.6 11.1 12.7 22.4 11.5 8.7 91.6 4.6 36.7 7.7 16.4 6.5 11.7 13.1 12.8 16.3 13.1 23.2 19.0 14.4 18.5 11.4 16.3 24.5 19.6 9.6 38.5 81.6 137.0 39.6 12.3 20.6 27.9 12.4 22.2 19.2 28.2 12.8 23.2 16.5 27.1 20.4 68.7 54.3 25.4 14.9 108.4 27.9 10.1 26.9 35.4 27.8 269.0 35.5 26.4 22.2 33.1 32.5 12.6 6.0 19.6 26.9 22.3 20.2 255.2 34.8 14.2 120.2 31.3 174.4 12.2 75.9 35.6 254.8 83.6 9.2 82.4 184.0 547.9 40.3 38.6 8.2 49.4 12.9 64.5 63.1 18.4 22.9 6.6 34.4 17.0 80.9 16.7 37.6 36.2 18.2 65.8 14.2 21.6 30.2 SSH3 "FLJ10928, FLJ20515" ENSG00000172830 "Slingshot protein phosphatase 3" Q8TE77 11 67303478-67312607 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 11.6;eosinophil: 11.1" "Lineage enriched" "Detected in many" 5 "granulocytes: 11.6" "Cell line enhanced" "Detected in many" "HaCaT: 64.9;MCF7: 64.1;RT4: 111.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019949, HPA019957" Approved Approved "Nuclear speckles,Plasma membrane,Actin filaments,Cytosol" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 15: RT4 - Unknown function" "Cluster 30: Mammary glandular cells - Lactation" "Nuclear speckles, Cytosol" "Plasma membrane, Actin filaments" "HPA019949: AB_1857498, HPA019957: AB_1857499" "unprognostic (4.38e-2)" "unprognostic (1.37e-1)" "unprognostic (3.50e-3)" "unprognostic (3.73e-2)" "unprognostic (2.61e-3)" "unprognostic (9.30e-2)" "unprognostic (2.99e-1)" "unprognostic (1.84e-1)" "unprognostic (1.63e-1)" "unprognostic (2.45e-2)" "prognostic unfavorable (2.89e-4)" "unprognostic (1.50e-1)" "unprognostic (2.06e-2)" "unprognostic (1.47e-1)" "unprognostic (3.20e-1)" "unprognostic (4.94e-3)" "unprognostic (6.78e-3)" 14.4 7.8 8.9 4.0 12.0 9.3 16.2 14.1 11.6 25.9 9.5 19.3 13.3 16.0 7.5 41.9 18.3 11.5 12.5 9.1 10.1 13.1 10.9 12.7 3.1 14.6 10.8 23.5 15.3 9.8 9.7 6.5 13.2 29.9 9.3 1.2 26.2 28.8 6.8 25.2 15.0 6.1 12.3 9.4 20.1 2.3 11.5 1.9 16.3 3.8 4.8 37.4 32.5 14.9 17.3 18.7 0.4 0.6 11.4 11.8 18.8 10.3 13.7 5.6 5.1 21.2 46.8 1.0 32.5 10.5 11.9 64.9 6.0 46.4 2.8 3.6 6.3 4.3 32.2 9.9 8.2 0.9 16.0 12.2 40.5 8.3 8.3 12.9 6.3 0.4 0.1 1.5 6.2 64.1 0.8 7.3 4.2 48.9 13.8 20.6 0.6 3.1 18.2 111.2 3.7 5.8 24.8 41.0 12.8 6.3 57.1 15.3 10.4 4.5 9.8 12.7 2.7 1.5 0.9 0.5 12.7 6.9 4.9 11.6 1.5 11.1 2.0 2.3 1.7 0.2 1.9 1.7 1.7 0.1 0.8 0.8 4.4 1.5 1.1 1.1 1.8 1.1 8.9 12.0 14.1 11.6 9.1 10.1 14.6 10.8 13.2 12.3 11.5 14.9 7.6 3.2 8.7 8.5 0.9 7.0 20.8 25.2 11.4 0.8 21.3 17.3 3.8 20.0 23.4 16.5 0.0 15.1 3.3 28.3 3.9 19.4 0.1 8.3 5.6 4.7 3.6 5.2 4.2 21.6 24.9 8.0 20.9 17.8 3.8 8.1 3.9 5.0 7.7 1.7 5.3 14.4 24.4 6.2 3.1 0.6 13.1 4.8 8.8 2.8 9.2 4.8 7.2 0.0 15.9 20.0 21.0 12.0 0.7 15.4 20.2 7.4 11.6 0.5 0.0 4.9 9.2 0.5 0.4 27.0 10.4 15.7 4.4 5.3 21.4 26.8 STYK1 "DKFZp761P1010, NOK, SuRTK106" ENSG00000060140 "Serine/threonine/tyrosine kinase 1" Q6J9G0 12 10618923-10674318 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Transferase, Tyrosine-protein kinase" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 17.1;stomach 1: 17.5" "Cell type enhanced" "Detected in many" "Distal enterocytes: 19.6;Excitatory neurons: 20.6;Gastric mucus-secreting cells: 15.3;Paneth cells: 12.6;Proximal enterocytes: 10.6" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in many" "cerebral cortex: 5.2" "Immune cell enriched" "Detected in some" 7 "NK-cell: 12.5" "Lineage enriched" "Detected in many" 7 "NK-cells: 12.5" "Cell line enhanced" "Detected in many" "CAPAN-2: 28.7;HDLM-2: 17.5;HMC-1: 18.3;HUVEC TERT2: 25.5;TIME: 23.8" "Region enhanced" "Detected in single" "basal ganglia: 2.3" "Not detected" "Not detected" "HPA040468, HPA048569" Enhanced Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 27: Mucus-secreting cells - Mucin production" "Plasma membrane" Nucleoplasm "HPA040468: AB_2676998, HPA048569: AB_2680446" "unprognostic (2.30e-1)" "unprognostic (2.22e-1)" "unprognostic (1.21e-1)" "unprognostic (1.75e-1)" "unprognostic (3.11e-2)" "unprognostic (3.35e-2)" "unprognostic (6.85e-2)" "unprognostic (5.08e-3)" "unprognostic (3.37e-1)" "unprognostic (3.50e-1)" "unprognostic (2.21e-3)" "unprognostic (1.02e-1)" "unprognostic (1.70e-14)" "unprognostic (5.18e-3)" "unprognostic (1.22e-1)" "unprognostic (2.33e-1)" "unprognostic (1.45e-2)" 0.4 0.3 1.2 1.8 3.0 1.1 3.9 0.0 5.2 1.9 0.0 15.9 2.4 0.5 1.2 7.3 2.2 3.5 0.1 3.6 0.0 0.6 0.3 1.3 1.4 0.0 0.0 0.3 0.3 0.0 2.4 0.7 0.0 11.6 17.1 0.9 6.7 0.9 0.1 2.8 11.2 0.6 0.0 0.9 17.5 0.2 0.0 0.2 0.4 0.0 2.5 5.1 3.3 0.3 4.8 0.2 0.0 0.6 0.0 0.0 1.3 7.3 0.7 3.5 3.4 2.6 28.7 0.3 4.7 1.8 4.5 1.4 1.6 8.0 7.4 17.5 0.4 1.0 2.4 0.2 0.0 2.2 18.3 0.4 0.4 5.1 0.3 0.5 25.5 0.2 0.3 0.3 8.1 3.1 0.2 1.3 4.2 11.8 2.0 0.1 2.0 0.3 2.5 14.6 0.9 0.1 4.5 4.9 0.0 6.7 3.5 0.6 23.8 1.0 3.8 0.5 0.8 0.0 1.0 0.2 3.5 0.2 5.5 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 1.0 0.1 12.5 0.0 0.0 0.0 0.3 1.2 3.0 0.0 5.2 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 2.2 0.0 0.0 0.3 0.8 3.1 1.2 0.6 3.3 2.0 0.7 1.5 3.3 0.0 0.0 0.1 1.8 19.6 0.0 0.5 0.2 7.3 0.5 0.4 4.2 0.8 20.6 0.2 0.6 0.2 15.3 4.5 1.3 6.3 0.0 0.0 0.0 0.0 1.6 8.9 2.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.1 0.0 6.2 0.0 0.5 5.9 12.6 0.0 0.9 4.7 10.6 0.0 8.8 0.4 0.0 1.2 0.2 0.2 0.8 3.1 1.0 0.3 1.9 0.0 6.9 5.5 STYXL1 "DUSP24, MK-STYX" ENSG00000127952 "Serine/threonine/tyrosine interacting like 1" Q9Y6J8 7 75996338-76048004 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 91.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA050261 Uncertain NA No "Cluster 31: Non-specific - Inflammatory response" "Cluster 27: Brain & Skin - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 49: Ciliated cells - Cilium organization" "HPA050261: AB_2681066" "unprognostic (6.24e-2)" "unprognostic (1.12e-1)" "unprognostic (7.21e-2)" "unprognostic (1.81e-2)" "unprognostic (2.88e-3)" "unprognostic (9.33e-2)" "unprognostic (1.50e-3)" "unprognostic (4.77e-2)" "unprognostic (8.01e-2)" "unprognostic (4.02e-2)" "unprognostic (4.47e-3)" "unprognostic (1.47e-1)" "unprognostic (1.87e-1)" "unprognostic (5.45e-2)" "unprognostic (3.17e-2)" "unprognostic (2.28e-1)" "prognostic favorable (8.22e-4)" 8.7 15.4 21.9 11.5 22.5 15.1 17.4 21.3 26.5 15.3 24.6 15.9 11.2 10.5 20.7 18.9 28.7 9.8 11.5 21.7 19.7 16.8 19.4 11.9 16.1 21.0 20.8 15.2 22.5 16.3 11.9 17.3 22.0 16.5 20.4 13.1 16.2 10.1 10.5 20.4 9.1 14.4 20.2 14.4 14.8 21.9 21.3 13.2 14.8 9.6 21.6 14.2 13.4 23.8 50.3 26.2 20.3 27.2 31.4 33.6 21.1 22.1 31.3 35.1 34.7 30.6 44.2 11.7 10.9 29.4 55.6 21.6 33.3 44.3 50.5 37.4 14.5 14.2 12.2 27.5 44.3 19.9 24.7 33.2 51.0 42.1 104.8 45.0 34.5 17.4 46.4 34.1 31.8 40.8 7.9 84.6 17.1 48.2 62.5 30.1 16.9 31.1 45.2 32.2 26.5 27.6 20.7 46.7 57.6 50.4 51.5 38.0 17.3 29.9 12.6 33.3 31.8 36.6 24.9 39.5 26.7 37.5 47.8 70.8 52.9 50.0 23.8 48.2 26.3 36.3 22.5 26.6 42.1 29.7 19.8 22.2 44.9 49.7 47.0 28.1 41.4 34.1 21.9 22.5 21.3 26.5 21.7 19.7 21.0 20.8 22.0 20.2 21.3 23.8 7.7 22.4 13.2 16.6 10.7 7.4 14.8 24.2 13.1 6.7 17.9 18.5 18.1 10.0 31.4 11.0 0.0 34.8 7.3 24.6 39.2 15.6 91.4 42.7 10.2 11.1 20.3 9.0 18.8 25.6 24.5 9.4 18.3 19.7 10.8 13.9 11.7 18.2 30.9 3.3 11.6 29.1 24.4 21.0 9.6 62.1 11.5 19.7 3.6 11.2 31.1 20.2 9.2 8.0 15.8 23.9 40.3 10.1 23.0 17.0 14.6 25.2 60.7 10.4 6.6 7.6 9.0 39.3 12.6 13.0 9.9 45.0 10.8 9.5 18.8 17.9 STYXL2 DUSP27 ENSG00000198842 "Serine/threonine/tyrosine interacting like 2" Q5VZP5 1 167094075-167129165 "Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 42 "heart muscle: 63.6;skeletal muscle: 114.6;tongue: 54.1" "Cell type enriched" "Detected in some" 7 "Cardiomyocytes: 143.6" "Group enriched" "Detected in many" 6 "colorectal cancer: 12.8;stomach cancer: 3.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 6 "RH-30: 14.2" "Low region specificity" "Detected in single" "Not detected" "Not detected" HPA012912 Approved Nucleoplasm NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm "HPA012912: AB_2668767" "unprognostic (1.26e-2)" "unprognostic (1.74e-1)" "unprognostic (1.44e-3)" "unprognostic (1.22e-1)" "unprognostic (2.10e-3)" "unprognostic (4.65e-2)" "unprognostic (1.53e-1)" "unprognostic (8.19e-2)" "unprognostic (1.07e-2)" "unprognostic (1.48e-1)" "unprognostic (2.44e-2)" "unprognostic (1.15e-1)" "unprognostic (2.72e-1)" "unprognostic (7.65e-2)" "unprognostic (8.23e-2)" "unprognostic (3.39e-1)" 0.1 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.9 0.1 0.1 63.6 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 1.7 0.0 0.9 1.6 0.0 114.6 0.1 0.0 0.2 0.0 0.0 0.0 0.1 0.2 0.0 0.0 54.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 14.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 143.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.5 3.6 0.0 0.0 0.0 0.0 0.0 0.0 18.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 SYK ENSG00000165025 "Spleen associated tyrosine kinase" P43405 9 90801787-90898549 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Adaptive immunity, Angiogenesis, Host-virus interaction, Immunity, Innate immunity" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 73.8;parathyroid gland: 87.6" "Cell type enhanced" "Detected in many" "B-cells: 91.3;Hofbauer cells: 73.1;Kupffer cells: 96.7;Macrophages: 95.2;Microglial cells: 114.3;monocytes: 92.5;Plasma cells: 83.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 13 "classical monocyte: 77.3;eosinophil: 83.5;intermediate monocyte: 64.0;memory B-cell: 74.5;myeloid DC: 85.1;naive B-cell: 58.4;neutrophil: 112.1;NK-cell: 30.0;non-classical monocyte: 60.2;plasmacytoid DC: 63.2" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "Daudi: 125.8;HEL: 72.8;HL-60: 101.6;HMC-1: 64.1;REH: 84.4;THP-1: 76.8;U-698: 58.8;U-937: 70.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA001384, CAB007773" Enhanced Approved "Vesicles,Plasma membrane,Cytosol" No NA 290000 "Cluster 5: Granulocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 3: HMC-1 - Innate immune response" "Cluster 57: B-cells - Immune response" "Plasma membrane, Cytosol" Vesicles "CAB007773: AB_562232, HPA001384: AB_1080144" "unprognostic (1.01e-1)" "unprognostic (5.45e-2)" "unprognostic (2.10e-1)" "unprognostic (2.69e-2)" "unprognostic (2.31e-1)" "unprognostic (7.92e-2)" "unprognostic (1.06e-1)" "unprognostic (1.34e-1)" "unprognostic (6.41e-2)" "unprognostic (1.78e-2)" "unprognostic (7.20e-2)" "unprognostic (9.93e-2)" "unprognostic (2.55e-3)" "unprognostic (8.77e-2)" "unprognostic (5.36e-3)" "unprognostic (3.41e-2)" "unprognostic (1.06e-2)" 7.4 4.6 4.1 42.5 4.1 50.9 6.8 4.5 4.9 7.7 4.2 20.1 30.8 4.1 16.1 17.5 17.0 12.9 2.9 3.8 5.0 11.2 4.5 20.6 61.8 7.1 5.8 1.7 9.1 87.6 2.4 12.0 7.0 3.8 20.5 0.7 8.4 4.2 1.0 9.9 36.3 9.3 6.6 40.3 19.1 6.9 7.1 49.7 25.6 2.4 73.8 17.5 8.3 9.8 22.7 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 14.3 125.8 3.5 0.0 4.2 19.1 2.7 10.2 0.0 0.0 17.0 72.8 0.0 0.0 0.0 101.6 64.1 0.0 14.0 0.0 1.4 0.0 0.0 15.5 2.0 9.9 0.0 15.4 0.1 44.4 0.7 47.0 0.0 84.4 0.1 34.6 2.6 18.6 6.4 5.7 0.1 8.7 0.1 0.3 7.9 76.8 0.2 0.0 0.4 0.1 0.1 0.2 0.0 58.8 0.0 70.3 0.0 5.3 77.3 83.5 0.3 64.0 0.3 74.5 0.2 0.2 85.1 58.4 0.2 0.1 112.1 30.0 60.2 63.2 0.1 44.6 4.1 4.1 4.5 4.9 3.8 5.0 7.1 5.8 7.0 6.6 7.1 9.8 0.5 12.8 20.2 0.0 91.3 3.4 3.7 8.7 12.0 1.4 6.3 2.8 1.6 14.3 12.8 14.7 0.0 1.3 70.4 16.5 15.6 15.0 7.1 10.7 1.0 2.1 10.3 37.9 0.4 12.5 2.6 2.1 22.4 12.6 43.6 0.0 3.3 1.0 73.1 0.0 0.7 24.4 0.0 96.7 28.8 6.2 0.6 95.2 12.4 114.3 92.5 0.0 62.8 1.5 0.5 18.2 25.1 0.0 83.1 2.5 31.4 0.4 10.4 0.2 6.6 0.7 2.3 0.8 0.7 30.4 5.7 1.4 8.3 0.0 31.1 8.0 TEC PSCTK4 ENSG00000135605 "Tec protein tyrosine kinase" P42680 4 48135783-48269838 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Adaptive immunity, Immunity" "Kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 13.9;Glandular and luminal cells: 25.1;granulocytes: 19.6;Plasma cells: 15.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Group enriched" "Detected in some" 5 "basophil: 20.7;eosinophil: 13.3" "Lineage enriched" "Detected in many" 6 "granulocytes: 20.7" "Cell line enhanced" "Detected in many" "HEL: 13.5;HMC-1: 20.3;U-266/70: 20.3;U-266/84: 15.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA005733, HPA024657" Approved Supported "Plasma membrane" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 29: U-266 - Adaptive immune response" "Cluster 44: Endometrium - Transcription" "Plasma membrane" "HPA005733: AB_1857878, HPA024657: AB_2671637" "unprognostic (7.19e-2)" "unprognostic (1.44e-1)" "unprognostic (1.41e-2)" "unprognostic (4.07e-3)" "unprognostic (4.21e-2)" "unprognostic (8.57e-2)" "unprognostic (3.14e-1)" "unprognostic (1.67e-1)" "unprognostic (8.36e-2)" "prognostic favorable (7.12e-4)" "unprognostic (7.46e-3)" "unprognostic (7.83e-2)" "unprognostic (1.01e-4)" "unprognostic (4.24e-2)" "unprognostic (2.16e-1)" "unprognostic (7.39e-2)" "unprognostic (4.96e-3)" 0.9 1.7 0.1 2.1 0.2 6.1 1.4 0.1 0.4 1.2 1.0 1.3 1.6 1.1 4.2 3.4 1.9 1.1 1.3 0.0 0.4 1.1 2.5 2.0 3.1 1.1 0.3 0.4 0.8 1.2 0.6 1.1 1.1 0.5 1.3 1.8 2.3 1.0 0.6 3.6 1.5 0.8 0.3 1.7 1.1 1.2 0.7 2.0 1.3 0.5 3.3 1.0 1.6 0.2 3.0 0.8 0.0 0.0 0.0 0.0 0.1 0.5 2.2 1.3 2.7 0.0 2.2 1.9 2.0 0.0 0.1 0.6 1.1 0.0 1.8 0.1 0.8 13.5 1.0 0.1 0.0 2.2 20.3 0.0 0.3 1.7 0.0 1.4 0.0 0.6 7.5 0.5 4.1 1.0 1.3 4.9 0.4 1.4 0.8 3.1 2.7 0.0 3.4 0.9 0.0 0.2 0.6 0.3 0.5 1.1 0.7 4.2 0.0 0.0 0.0 2.8 0.0 20.3 15.4 2.6 0.0 3.0 0.1 20.7 0.6 13.3 0.1 0.7 0.3 1.0 0.2 0.5 1.5 0.7 0.5 0.5 0.5 3.6 0.1 0.1 0.1 0.4 0.1 0.2 0.1 0.4 0.0 0.4 1.1 0.3 1.1 0.3 0.7 0.2 0.6 6.4 6.8 0.7 6.8 2.5 1.7 0.2 2.8 0.9 1.7 1.1 1.8 7.2 2.6 0.0 0.0 1.5 3.3 2.1 0.0 1.7 6.4 13.9 1.5 1.2 3.0 12.6 6.7 1.1 0.1 0.8 0.0 25.1 19.6 0.7 0.0 2.9 4.9 0.0 1.6 1.4 4.1 4.6 1.8 2.6 0.0 5.9 1.8 10.3 1.7 6.6 0.0 0.5 0.2 1.0 0.6 0.4 15.4 1.3 3.0 2.0 0.2 3.1 6.6 1.8 0.8 0.7 1.4 9.8 3.0 0.8 3.4 0.3 2.1 1.6 TEK "CD202b, TIE-2, TIE2, VMCM, VMCM1" ENSG00000120156 "TEK receptor tyrosine kinase" Q02763 9 27109141-27230174 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" Angiogenesis "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Glaucoma" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 46.3" "Group enriched" "Detected in many" 10 "Adipocytes: 70.8;Endothelial cells: 73.9;Hepatic stellate cells: 122.0;Microglial cells: 38.4;Oligodendrocyte precursor cells: 137.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "HUVEC TERT2: 90.9;NTERA-2: 45.2;TIME: 99.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010359, HPA073265" Approved Supported "Plasma membrane,Centriolar satellite" "Secreted to blood" NA NA 7750000 13000000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Plasma membrane" "Centriolar satellite" "CAB010359: AB_2203226, HPA073265: AB_2686592" "unprognostic (2.24e-1)" "unprognostic (1.74e-1)" "unprognostic (5.55e-2)" "unprognostic (1.83e-2)" "unprognostic (1.68e-1)" "unprognostic (1.26e-3)" "prognostic favorable (2.31e-5)" "unprognostic (7.48e-2)" "unprognostic (1.72e-2)" "unprognostic (1.41e-1)" "unprognostic (5.58e-2)" "unprognostic (2.72e-1)" "prognostic favorable (7.81e-4)" "unprognostic (7.50e-3)" "unprognostic (6.87e-3)" "unprognostic (1.83e-1)" "unprognostic (5.24e-3)" 20.1 9.1 8.1 5.8 7.0 0.2 14.0 6.1 8.4 9.3 4.3 5.0 3.7 12.4 2.3 5.3 6.7 11.2 16.8 7.1 6.8 23.0 10.5 28.8 3.7 7.2 6.6 3.5 3.5 4.4 3.0 46.3 7.6 3.8 5.4 0.7 3.1 6.2 10.5 2.8 5.5 12.7 6.8 28.8 4.0 1.4 9.4 1.8 9.1 22.9 2.8 6.9 3.9 6.8 0.3 0.0 3.5 0.0 0.4 5.6 0.1 3.2 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.0 2.4 0.0 1.6 0.0 0.0 1.8 0.0 2.2 0.8 0.1 90.9 0.0 0.0 0.0 0.7 0.0 0.0 0.0 45.2 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 18.3 0.0 0.0 99.1 0.0 0.5 9.1 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 8.1 7.0 6.1 8.4 7.1 6.8 7.2 6.6 7.6 6.8 9.4 6.8 70.8 3.2 1.3 1.3 0.4 1.5 0.0 0.0 0.0 0.0 0.3 0.5 8.6 0.0 0.6 1.8 0.0 0.4 0.4 0.0 0.0 0.0 0.6 0.6 0.8 73.9 0.0 2.7 4.3 0.0 2.8 4.2 0.0 0.7 0.0 0.3 122.0 1.3 0.3 0.0 5.0 0.0 0.0 6.7 2.2 0.9 0.6 0.4 0.0 38.4 0.0 0.1 0.0 137.7 2.1 1.3 0.0 0.4 0.0 0.2 0.0 0.1 0.0 0.2 0.0 1.6 1.9 0.1 0.4 0.3 1.3 1.4 0.5 1.8 0.0 0.0 TESK1 ENSG00000107140 "Testis associated actin remodelling kinase 1" Q15569 9 35605262-35610041 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 41: Macrophages - Immune response" "unprognostic (5.17e-2)" "unprognostic (2.82e-1)" "unprognostic (4.96e-3)" "unprognostic (5.18e-2)" "unprognostic (2.04e-2)" "unprognostic (8.76e-2)" "prognostic unfavorable (9.68e-4)" "unprognostic (1.82e-2)" "unprognostic (1.24e-1)" "unprognostic (2.66e-3)" "unprognostic (1.22e-2)" "unprognostic (2.56e-1)" "unprognostic (5.57e-2)" "unprognostic (1.74e-2)" "unprognostic (2.34e-1)" "unprognostic (1.43e-2)" "unprognostic (1.25e-3)" 40.2 44.7 24.4 11.2 22.0 6.1 33.5 17.9 25.9 22.6 14.8 29.9 13.3 25.7 11.1 12.8 18.7 13.0 19.2 22.0 21.3 18.0 13.8 19.9 11.9 20.6 24.2 15.9 16.0 16.8 26.6 9.1 21.8 22.4 8.5 6.7 17.4 19.8 69.2 19.1 18.9 17.1 18.2 16.2 22.2 57.0 28.1 10.4 19.0 27.6 8.5 27.9 16.0 20.4 17.0 16.0 10.7 16.9 42.5 17.5 12.1 19.7 17.3 17.8 11.3 9.3 4.8 30.9 10.3 19.7 47.1 5.8 6.8 14.1 3.4 20.0 9.2 4.6 14.1 8.4 24.4 4.0 14.6 17.2 21.8 13.9 19.0 18.9 12.6 15.3 5.3 11.3 18.0 19.1 7.9 18.4 6.2 16.1 18.6 12.9 6.6 7.3 13.1 8.0 8.8 10.3 11.2 13.0 8.1 7.3 15.9 5.7 11.1 39.2 16.2 27.9 12.0 6.0 10.2 11.2 28.2 4.6 9.1 0.0 0.6 0.1 1.1 0.1 1.0 0.3 0.4 1.8 0.8 0.2 0.5 0.5 0.0 0.9 0.3 0.8 0.1 0.7 24.4 22.0 17.9 25.9 22.0 21.3 20.6 24.2 21.8 18.2 28.1 20.4 13.4 6.4 7.7 9.1 8.9 14.4 6.3 5.9 4.6 10.9 13.9 11.0 1.9 7.2 4.2 7.3 8.4 3.8 20.0 19.9 1.9 6.6 35.1 5.6 9.2 9.7 9.5 1.7 6.5 10.4 8.6 9.0 18.8 11.2 1.3 10.1 10.8 8.4 13.9 13.5 8.5 14.8 0.0 7.8 22.4 34.9 12.2 19.3 14.2 2.8 6.3 12.6 20.6 4.5 6.8 10.2 11.0 14.3 10.7 19.2 13.4 7.8 4.2 15.3 6.6 10.1 10.9 14.8 10.0 4.7 13.9 3.3 11.8 5.4 7.3 9.7 TESK2 ENSG00000070759 "Testis associated actin remodelling kinase 2" Q96S53 1 45343883-45491163 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in many" 4 "Oligodendrocytes: 222.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BEWO: 14.6;RT4: 14.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027257, HPA063869" Uncertain Enhanced Nucleoplasm NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 2: Karpas-707 - Immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA027257: AB_10602477, HPA063869: AB_2685137" "unprognostic (2.95e-1)" "prognostic favorable (2.22e-4)" "unprognostic (3.90e-2)" "unprognostic (5.04e-3)" "unprognostic (6.03e-2)" "unprognostic (1.87e-3)" "unprognostic (3.22e-2)" "unprognostic (1.43e-2)" "unprognostic (5.15e-2)" "unprognostic (2.96e-1)" "unprognostic (2.28e-1)" "unprognostic (2.86e-1)" "unprognostic (4.36e-2)" "unprognostic (2.49e-2)" "unprognostic (1.13e-1)" "unprognostic (4.37e-2)" "unprognostic (2.01e-1)" 3.8 2.1 7.1 2.8 10.6 10.2 6.6 10.3 8.3 6.4 4.8 5.3 8.6 3.2 3.7 7.1 3.0 2.6 2.4 7.3 8.0 2.5 6.9 3.9 3.9 10.8 10.1 9.8 3.6 3.4 2.4 3.5 10.3 15.5 7.0 2.8 8.4 2.6 8.3 12.7 10.8 2.9 8.5 5.3 4.5 9.6 9.9 4.2 3.4 4.7 5.2 4.7 7.4 15.1 1.9 0.0 0.9 0.1 3.5 1.8 14.6 0.7 4.9 2.1 3.6 4.3 1.7 6.2 0.6 1.8 5.4 2.3 3.9 3.1 1.6 4.4 4.9 4.2 2.0 3.2 1.9 1.4 11.1 1.9 3.2 2.4 3.4 3.2 1.7 8.1 0.8 12.4 1.4 0.7 3.6 2.9 3.8 1.8 1.8 5.2 0.1 1.5 1.9 14.7 0.4 1.6 3.8 7.3 14.1 8.6 11.3 1.8 0.0 0.2 2.1 1.3 1.3 8.0 5.0 1.2 1.1 0.0 1.0 12.8 4.6 13.3 2.7 3.4 1.9 8.0 2.5 1.8 2.4 6.6 4.1 2.3 19.0 1.5 8.0 1.3 1.9 3.4 7.1 10.6 10.3 8.3 7.3 8.0 10.8 10.1 10.3 8.5 9.9 15.1 3.9 0.0 2.8 54.2 10.7 7.8 7.1 2.8 14.2 2.4 11.9 9.4 1.3 4.3 3.4 0.0 14.6 8.3 4.2 13.9 0.0 1.3 23.7 4.6 1.8 3.2 4.2 5.0 10.2 2.7 2.8 3.7 7.7 8.9 7.0 2.4 2.2 6.3 6.8 0.0 6.7 6.9 4.1 5.5 4.4 7.8 2.8 6.0 3.6 15.9 4.6 1.1 4.1 18.6 222.9 1.1 7.3 1.9 9.8 10.6 14.9 1.2 2.0 3.1 6.6 2.6 6.1 22.0 13.6 12.6 8.5 14.8 4.7 1.8 4.9 8.0 TIE1 "JTK14, TIE" ENSG00000066056 "Tyrosine kinase with immunoglobulin like and EGF like domains 1" P35590 1 43300982-43323108 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" Angiogenesis "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in many" 4 "Adipocytes: 130.8;Endothelial cells: 108.8;Hepatic stellate cells: 128.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 24 "basophil: 2.1;NK-cell: 2.5" "Group enriched" "Detected in many" 24 "granulocytes: 2.1;NK-cells: 2.5" "Group enriched" "Detected in some" 4 "EFO-21: 106.3;HUVEC TERT2: 238.4;TIME: 210.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "Intracellular and membrane" NA NA 87000000 "Cluster 41: Basophils - Cellular respiration" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "unprognostic (1.88e-1)" "unprognostic (1.26e-1)" "unprognostic (7.60e-3)" "unprognostic (1.01e-1)" "unprognostic (3.91e-2)" "unprognostic (1.53e-3)" "unprognostic (1.19e-2)" "unprognostic (7.83e-2)" "unprognostic (2.02e-1)" "unprognostic (9.34e-2)" "unprognostic (1.91e-2)" "unprognostic (2.25e-1)" "unprognostic (1.17e-3)" "unprognostic (2.16e-2)" "unprognostic (1.89e-1)" "unprognostic (1.29e-2)" "unprognostic (2.35e-2)" 47.0 10.1 16.6 8.1 14.8 0.9 37.8 14.6 16.9 14.0 10.1 11.2 5.2 20.4 5.3 6.5 16.0 13.3 34.2 13.1 14.2 19.8 6.7 35.3 10.1 16.4 16.5 7.5 4.2 3.2 8.0 48.6 16.8 10.8 3.1 0.4 7.4 6.5 14.0 7.9 11.0 14.1 13.9 19.9 8.8 3.0 21.1 2.1 24.2 20.7 2.9 15.1 11.8 14.8 0.0 0.0 3.6 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.1 106.3 0.0 0.0 0.0 0.0 0.0 1.8 0.1 0.0 41.9 0.0 0.4 0.6 0.0 0.0 0.0 0.0 0.2 0.0 1.7 238.4 0.0 0.0 0.0 0.0 0.0 0.0 20.4 1.3 0.0 0.1 8.1 16.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.9 0.0 0.1 210.0 1.2 0.4 0.0 0.2 0.0 0.2 0.4 0.0 0.0 3.9 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 16.6 14.8 14.6 16.9 13.1 14.2 16.4 16.5 16.8 13.9 21.1 14.8 130.8 0.0 4.2 0.0 0.4 2.2 0.6 0.0 1.2 0.3 1.0 0.9 4.9 1.5 1.8 0.0 0.0 0.3 0.7 0.9 0.0 0.0 2.0 0.1 0.4 108.8 0.0 2.5 0.4 0.2 0.1 3.1 0.0 0.4 20.3 0.1 128.8 1.3 0.5 0.0 0.2 0.1 0.0 5.6 3.1 2.5 2.1 1.1 1.8 29.0 0.1 0.1 1.0 1.0 1.1 0.0 0.0 0.7 0.1 0.7 0.1 0.9 3.6 0.9 0.0 2.2 2.2 0.9 0.7 0.5 1.4 0.3 2.3 0.5 0.2 0.7 TNK1 KOS1 ENSG00000174292 "Tyrosine kinase non receptor 1" Q13470 17 7380534-7389774 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 13.1;Distal enterocytes: 13.9;Gastric mucus-secreting cells: 16.8;Proximal enterocytes: 11.6" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in single" "cerebellum: 1.9" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "A-431: 5.7;HaCaT: 9.1;HBEC3-KT: 6.0;hTCEpi: 6.6;T-47d: 7.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA012065, HPA056452" Uncertain Approved "Cell Junctions" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 35: Glandular cells - Unknown function" "Cell Junctions" "HPA012065: AB_1858165, HPA056452: " "unprognostic (4.90e-2)" "unprognostic (1.93e-1)" "unprognostic (2.95e-1)" "prognostic favorable (4.28e-4)" "unprognostic (2.84e-1)" "unprognostic (1.60e-1)" "unprognostic (1.41e-2)" "unprognostic (3.65e-1)" "unprognostic (2.20e-1)" "unprognostic (2.52e-2)" "unprognostic (2.43e-1)" "unprognostic (3.10e-1)" "prognostic favorable (6.40e-4)" "unprognostic (1.77e-3)" "unprognostic (1.61e-1)" "unprognostic (1.38e-1)" "prognostic favorable (1.52e-4)" 3.6 0.9 0.3 1.2 0.5 0.2 5.6 1.9 0.4 3.8 0.4 7.3 3.7 2.4 0.8 7.1 3.1 1.0 1.6 0.2 0.3 5.2 5.1 2.6 1.5 0.0 0.0 3.3 7.8 3.0 3.0 0.2 0.0 7.0 2.3 1.3 8.1 1.4 0.5 8.8 7.7 0.5 0.0 3.1 7.6 1.9 0.2 0.5 4.8 0.1 1.7 4.2 5.6 0.3 5.7 0.9 0.1 0.4 0.0 0.0 3.7 0.2 0.0 0.3 0.4 2.9 2.6 0.0 2.2 0.3 0.1 9.1 0.0 6.0 0.1 0.6 1.3 0.0 3.5 1.6 0.3 0.0 0.2 0.1 6.6 0.0 1.0 0.1 0.0 2.4 0.7 0.0 0.0 4.4 0.6 0.0 0.7 4.9 0.7 0.2 0.1 0.6 4.1 2.6 0.1 0.4 3.1 4.5 0.8 0.2 7.4 0.1 1.5 0.2 0.7 0.2 0.0 0.4 0.9 0.1 0.1 0.4 0.4 0.0 0.0 0.0 0.3 0.0 0.6 0.5 0.6 0.4 0.0 0.4 1.1 1.3 0.1 0.0 0.0 0.0 0.2 0.2 0.3 0.5 1.9 0.4 0.2 0.3 0.0 0.0 0.0 0.0 0.2 0.3 2.6 6.4 3.4 0.0 2.9 2.5 2.6 5.1 13.1 1.8 9.1 7.4 1.1 2.8 3.5 1.8 0.0 0.2 0.3 13.9 0.0 5.2 1.5 2.8 1.0 1.5 3.0 0.4 0.5 6.9 0.6 1.0 16.8 4.6 0.0 0.1 1.1 2.9 0.1 0.0 0.4 7.0 2.0 0.0 0.5 1.5 1.2 0.4 0.0 0.0 0.4 0.2 2.1 0.0 0.1 8.5 8.0 0.4 0.4 3.9 11.6 1.6 1.9 2.9 0.0 0.8 1.8 1.5 0.6 11.0 2.4 0.7 2.4 0.1 7.2 2.2 TNK2 "ACK, ACK1, p21cdc42Hs" ENSG00000061938 "Tyrosine kinase non receptor 2" Q07912 3 195863364-195911945 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Endocytosis "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 102.9" "Cell type enhanced" "Detected in many" "Horizontal cells: 99.3;Oligodendrocyte precursor cells: 245.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041954, HPA069561" Approved Supported "Vesicles,Plasma membrane" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 44: HDLM-2 - Immune response" "Cluster 68: Oligodendrocytes - Mixed function" "Plasma membrane" Vesicles "HPA041954: AB_10794164, HPA069561: " "unprognostic (1.97e-2)" "unprognostic (1.05e-1)" "unprognostic (1.15e-3)" "prognostic unfavorable (8.96e-4)" "unprognostic (1.34e-1)" "unprognostic (8.92e-2)" "unprognostic (1.45e-1)" "unprognostic (1.30e-1)" "unprognostic (8.89e-3)" "unprognostic (1.13e-1)" "unprognostic (8.92e-3)" "unprognostic (4.49e-2)" "prognostic unfavorable (1.30e-4)" "unprognostic (6.82e-2)" "unprognostic (9.76e-2)" "unprognostic (1.44e-1)" "prognostic favorable (1.00e-4)" 14.2 10.0 77.1 24.7 64.1 72.2 15.0 40.0 102.9 18.0 11.8 18.5 9.4 13.8 11.1 19.1 17.1 10.5 18.4 75.6 51.4 7.7 10.5 14.1 30.0 77.5 59.8 13.4 12.1 6.1 36.4 12.7 70.1 21.1 6.3 9.3 26.3 11.8 54.8 62.3 16.1 9.2 45.5 27.0 19.7 12.0 57.0 16.0 10.0 16.7 20.1 19.4 19.3 60.6 93.4 16.3 15.4 13.4 15.3 11.5 80.0 17.7 16.7 11.7 9.4 15.6 79.3 25.9 55.1 24.2 17.4 34.1 14.9 22.2 3.5 61.8 15.4 22.0 36.2 10.4 7.9 13.5 10.2 7.8 30.7 11.7 17.9 26.7 13.3 9.2 11.3 30.6 9.4 67.1 5.3 39.7 12.3 24.6 29.1 13.8 15.6 26.0 7.2 51.2 16.2 16.5 9.5 37.6 21.3 11.3 71.4 11.9 18.9 19.1 13.0 11.4 48.6 70.8 9.2 17.0 22.1 38.0 15.4 1.4 1.2 0.3 0.9 1.5 0.4 1.3 0.8 0.4 0.5 2.5 0.5 0.5 2.7 0.4 1.4 1.5 0.1 0.7 77.1 64.1 40.0 102.9 75.6 51.4 77.5 59.8 70.1 45.5 57.0 60.6 9.3 6.4 7.7 44.4 14.6 6.9 8.1 6.0 4.6 30.6 13.0 12.6 16.1 7.2 8.9 0.0 50.1 13.4 11.0 18.0 1.9 4.0 1.0 4.1 5.4 11.1 6.1 12.8 42.7 5.3 3.3 4.6 14.3 4.1 1.3 4.5 11.7 19.2 8.1 99.3 45.3 2.3 6.1 16.0 11.7 1.2 6.5 13.7 5.4 20.6 16.2 5.9 21.6 245.3 25.1 29.5 9.6 6.4 10.7 8.2 0.9 1.6 7.6 20.3 0.0 4.8 5.7 6.4 11.2 11.0 10.5 4.2 12.5 1.7 6.4 19.0 TPST1 TANGO13A ENSG00000169902 "Tyrosylprotein sulfotransferase 1" O60507 7 66205317-66420543 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 76.5;Excitatory neurons: 101.9;Inhibitory neurons: 107.1;Spermatocytes: 97.1" "Cancer enhanced" "Detected in all" "glioma: 36.5" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 52.2;neutrophil: 35.2" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA047415, HPA061837" Approved Supported "Golgi apparatus" "Intracellular and membrane" NA NA "Cluster 10: Basophils - Unknown function" "Cluster 15: Liver - Metabolism" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 33: Fibroblasts - ECM organization" "Golgi apparatus" "HPA047415: AB_10964056, HPA061837: AB_2732672" "unprognostic (7.46e-2)" "unprognostic (1.45e-1)" "unprognostic (8.62e-2)" "unprognostic (3.43e-2)" "unprognostic (3.52e-2)" "unprognostic (1.78e-3)" "unprognostic (5.71e-2)" "unprognostic (8.21e-2)" "unprognostic (3.59e-1)" "unprognostic (9.25e-3)" "unprognostic (4.12e-2)" "unprognostic (4.98e-1)" "prognostic unfavorable (8.16e-6)" "prognostic unfavorable (8.78e-4)" "unprognostic (2.48e-1)" "unprognostic (1.74e-2)" "prognostic unfavorable (3.73e-5)" 16.9 15.8 22.1 10.8 20.5 6.0 13.4 18.4 21.6 35.4 12.3 11.1 3.2 21.8 14.3 10.8 11.2 38.1 8.5 19.4 36.7 23.1 46.0 11.5 5.9 37.2 25.0 13.5 7.8 11.0 19.5 26.4 24.7 15.1 8.0 5.2 6.8 16.4 2.7 8.2 8.7 16.2 22.9 12.0 10.9 23.0 33.8 2.1 11.3 5.6 5.3 36.8 22.1 22.5 12.1 6.5 16.5 22.4 52.7 42.0 5.7 22.3 49.8 25.7 37.1 21.9 6.6 1.4 17.7 45.1 38.9 8.9 16.2 24.8 33.3 3.5 9.3 2.3 15.1 16.5 62.3 1.8 1.9 59.5 19.0 50.2 22.1 27.8 32.7 2.9 1.0 10.2 40.2 6.2 0.1 3.1 15.5 0.4 9.6 7.8 14.6 11.4 27.3 11.5 10.4 44.5 27.8 2.1 62.2 32.4 8.6 4.7 62.3 33.1 21.3 24.2 40.6 9.2 13.3 4.7 29.6 6.8 48.2 52.2 2.3 23.9 0.8 0.1 0.8 6.1 0.5 0.6 0.3 14.0 2.2 4.1 35.2 8.8 0.0 0.0 0.0 1.9 22.1 20.5 18.4 21.6 19.4 36.7 37.2 25.0 24.7 22.9 33.8 22.5 33.8 0.0 8.9 38.8 11.5 10.8 7.7 24.4 33.6 8.5 4.0 13.3 1.6 5.7 9.6 31.3 2.1 1.8 3.8 0.2 9.8 23.0 11.2 13.3 76.5 17.9 7.7 1.3 101.9 47.6 4.3 58.5 12.2 9.7 4.5 12.2 10.0 34.1 16.2 6.7 107.1 0.8 8.2 8.9 8.9 11.6 48.1 6.2 14.2 32.8 15.8 5.0 1.0 61.3 38.8 23.7 0.1 37.2 7.1 5.3 0.0 3.2 19.5 3.6 6.6 16.4 21.6 97.1 41.3 15.1 7.5 3.8 2.8 12.6 0.7 7.7 TPST2 TANGO13B ENSG00000128294 "Tyrosylprotein sulfotransferase 2" O60704 22 26521996-26596717 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "pancreas: 398.8" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 171.0;NK-cells: 263.7;Plasma cells: 183.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HMC-1: 158.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021054 Enhanced "Intracellular and membrane" NA NA 88000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 25: Pancreas - Digestion" "Cluster 3: HMC-1 - Innate immune response" "Cluster 55: Plasma cells - Humoral immune response" "HPA021054: AB_1858221" "unprognostic (2.24e-1)" "unprognostic (1.70e-1)" "unprognostic (1.74e-2)" "prognostic favorable (8.08e-5)" "unprognostic (8.88e-2)" "unprognostic (1.06e-1)" "unprognostic (1.19e-2)" "unprognostic (9.70e-2)" "unprognostic (3.18e-2)" "unprognostic (3.38e-1)" "unprognostic (2.70e-1)" "unprognostic (5.54e-2)" "prognostic unfavorable (2.34e-6)" "unprognostic (9.68e-2)" "unprognostic (9.21e-3)" "unprognostic (5.62e-2)" "unprognostic (2.01e-1)" 24.4 31.0 24.4 15.2 20.8 23.1 21.8 19.1 29.9 17.4 26.9 11.5 13.6 18.0 111.6 18.7 17.0 12.2 27.5 23.4 22.9 24.9 74.9 45.7 19.1 22.0 24.2 9.2 398.8 5.3 9.9 41.8 20.8 16.0 8.8 3.3 10.9 17.8 38.5 18.4 13.4 12.1 23.1 36.4 11.7 20.6 34.2 10.7 38.8 22.6 17.0 17.1 17.3 20.7 12.8 9.1 11.7 6.0 24.4 18.7 16.4 27.9 49.9 22.2 20.3 6.2 6.5 21.4 7.3 50.4 11.6 19.5 8.8 19.2 12.7 8.8 16.9 51.8 5.6 13.1 10.2 6.0 158.7 20.1 30.3 22.5 7.7 22.5 41.6 9.6 52.6 65.2 17.2 14.3 24.3 40.7 15.4 10.0 9.1 22.5 15.8 60.2 6.7 14.3 8.8 6.1 12.9 11.2 16.0 17.0 5.2 24.7 33.2 27.3 61.2 22.5 27.3 20.9 31.5 20.6 20.7 23.1 25.3 490.4 77.0 111.9 249.2 86.3 70.5 23.6 57.0 187.2 48.3 25.6 27.8 163.6 163.0 354.9 94.3 115.3 71.9 240.7 24.4 20.8 19.1 29.9 23.4 22.9 22.0 24.2 20.8 23.1 34.2 20.7 37.3 16.0 12.6 13.7 30.8 38.1 82.5 29.9 14.2 9.0 10.8 13.1 15.5 47.1 14.4 22.0 6.2 171.0 120.8 6.7 27.4 12.9 15.2 31.1 14.8 66.1 0.0 64.6 23.4 65.1 49.8 10.7 5.1 39.5 53.7 13.9 113.6 79.3 123.9 6.7 20.3 9.3 12.2 55.9 48.6 4.5 5.3 70.1 28.4 47.8 32.4 1.9 263.7 5.0 1.9 53.1 8.7 4.1 183.7 36.4 16.5 7.6 18.6 5.3 6.6 9.9 15.3 2.9 13.2 15.1 35.9 143.0 64.4 42.0 11.8 83.7 TPTE "CT44, PTEN2" ENSG00000274391 "Transmembrane phosphatase with tensin homology" P56180 21 10521553-10606140 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 201 "testis: 107.2" "Cell type enriched" "Detected in some" 6 "Spermatocytes: 464.7" "Cancer enriched" "Detected in single" 7 "testis cancer: 0.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 6.7;K-562: 8.2;Karpas-707: 6.4;MCF7: 4.9;PC-3: 4.8;RPMI-8226: 9.0;SuSa: 7.6;U-266/70: 7.7" "HPA049690, HPA068342" Enhanced Approved "Endoplasmic reticulum,Cytosol" NA NA "Cluster 36: Testis - Spermatogenesis" "Cluster 2: Karpas-707 - Immune response" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Cytosol "Endoplasmic reticulum" "HPA049690: AB_2680850, HPA068342: AB_2685976" "unprognostic (3.63e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 107.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.2 6.4 0.0 4.9 0.0 0.0 1.0 0.0 4.8 0.0 0.0 9.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 7.6 0.0 0.0 0.0 1.8 4.1 2.1 0.0 7.7 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 20.6 0.1 0.0 0.1 0.0 0.0 0.7 0.0 1.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.6 0.0 0.0 0.0 0.3 13.9 5.0 0.1 0.0 1.9 0.0 0.0 0.0 0.5 0.3 0.0 0.0 2.6 0.0 0.0 0.0 0.4 0.0 0.0 13.1 0.0 0.0 464.7 69.0 0.0 0.0 1.1 0.0 0.0 0.0 0.1 TTK "CT96, MPH1, MPS1, MPS1L1" ENSG00000112742 "TTK protein kinase" P33981 6 80003887-80042527 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "bone marrow: 25.3;lymphoid tissue: 46.6;testis: 34.3" "Cell type enhanced" "Detected in many" "Early spermatids: 43.3;Erythroid cells: 23.1;Late spermatids: 21.4;Spermatocytes: 130.5;Spermatogonia: 33.0" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "T-reg: 1.2" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in single" "CAB010166, CAB013229" Enhanced Approved Nucleoli,Cytosol NA Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" "Nucleoli, Cytosol" "CAB010166: AB_632567, CAB013229: AB_2533230" "unprognostic (4.27e-2)" "unprognostic (8.71e-2)" "unprognostic (1.04e-2)" "prognostic unfavorable (1.44e-5)" "unprognostic (7.97e-2)" "unprognostic (4.78e-2)" "prognostic unfavorable (3.84e-10)" "unprognostic (1.56e-3)" "unprognostic (7.95e-2)" "unprognostic (2.02e-3)" "prognostic unfavorable (2.54e-4)" "unprognostic (1.54e-1)" "unprognostic (0.00e+0)" "unprognostic (3.51e-2)" "unprognostic (1.06e-1)" "unprognostic (1.46e-1)" "unprognostic (1.66e-1)" 0.7 0.8 0.0 4.2 0.1 25.3 2.2 0.1 0.3 0.7 0.0 4.8 4.0 1.0 0.1 4.8 0.6 0.5 0.1 0.1 0.1 0.2 0.5 0.8 8.1 0.2 0.1 0.2 0.2 0.3 0.0 3.9 0.2 0.8 5.9 1.8 0.7 0.1 0.0 3.6 4.1 1.7 0.1 1.4 3.3 34.3 0.2 46.6 0.4 0.1 9.0 1.2 1.4 0.2 39.9 23.4 68.2 56.4 3.1 9.5 38.5 44.9 27.4 64.2 77.8 32.1 29.6 58.5 34.1 19.5 66.9 50.0 60.7 27.6 88.6 53.4 49.3 54.1 29.4 26.5 0.2 64.4 33.9 1.2 2.8 45.0 28.6 9.6 36.9 80.6 60.2 58.5 55.2 29.5 37.0 46.4 40.4 35.4 27.9 32.7 124.4 24.4 16.3 25.2 46.8 27.4 26.6 28.3 16.3 36.6 26.6 48.3 15.4 28.8 28.5 18.8 72.9 13.1 47.1 32.4 10.3 58.9 25.1 0.0 0.0 0.3 0.1 0.0 0.1 0.2 0.2 0.4 0.0 0.7 0.0 0.1 0.0 0.3 0.0 0.0 1.2 0.2 0.0 0.1 0.1 0.3 0.1 0.1 0.2 0.1 0.2 0.1 0.2 0.2 0.3 3.2 1.1 0.0 1.4 1.3 0.6 2.6 0.0 0.2 0.9 0.5 0.6 0.0 2.3 0.0 2.1 9.8 0.8 2.2 3.9 0.4 43.3 3.1 1.6 1.1 1.8 23.1 0.2 0.2 15.0 2.1 2.6 2.3 1.3 13.9 0.7 0.2 6.5 0.0 0.2 3.0 4.1 2.6 1.2 21.4 0.9 1.9 0.0 0.0 5.2 0.2 1.0 0.0 0.1 0.6 0.2 0.7 5.1 0.4 0.3 0.1 3.0 1.6 6.6 0.1 1.7 130.5 33.0 8.5 0.3 3.7 1.1 0.5 5.6 1.6 TXK "BTKL, PSCTK5, PTK4, RLK, TKL" ENSG00000074966 "TXK tyrosine kinase" P42681 4 48066393-48134250 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Adaptive immunity, Immunity, Transcription, Transcription regulation" "Kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "epididymis: 12.4;lymphoid tissue: 15.8" "Cell type enhanced" "Detected in many" "dendritic cells: 84.1;NK-cells: 288.4;T-cells: 52.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Immune cell enhanced" "Detected in many" "NK-cell: 152.3" "Group enriched" "Detected in many" 19 "NK-cells: 152.3;T-cells: 54.8" "Cell line enhanced" "Detected in some" "CAPAN-2: 6.1;HMC-1: 14.0;U-266/70: 6.8;U-266/84: 9.2;WM-115: 32.0" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA062482 Approved Vesicles NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 17: WM-115 - Nervous system development" "Cluster 63: NK-cells & T-cells - Immune response" Vesicles "HPA062482: AB_2684778" "unprognostic (1.04e-2)" "unprognostic (2.21e-2)" "unprognostic (4.13e-2)" "unprognostic (9.24e-3)" "unprognostic (1.09e-2)" "unprognostic (2.58e-4)" "unprognostic (1.32e-1)" "unprognostic (1.94e-1)" "unprognostic (1.50e-1)" "unprognostic (6.39e-3)" "unprognostic (8.13e-2)" "unprognostic (4.06e-1)" "unprognostic (1.33e-1)" "unprognostic (1.37e-1)" "unprognostic (1.61e-1)" "unprognostic (2.59e-1)" "unprognostic (2.04e-2)" 0.9 1.0 0.1 7.8 0.0 5.6 0.9 0.0 0.4 0.8 0.3 1.5 1.8 1.0 12.4 1.5 2.0 2.2 0.6 0.0 0.5 1.1 2.1 2.8 15.8 1.2 0.2 0.2 0.8 0.4 0.7 1.9 1.5 0.5 1.4 2.0 1.4 0.5 0.6 2.2 5.6 0.4 0.2 10.6 1.1 1.1 0.8 5.7 1.2 0.0 10.8 2.2 0.9 0.2 3.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.5 0.1 6.1 0.0 1.8 0.0 0.2 0.3 0.0 0.1 0.6 0.3 0.1 3.1 0.0 0.0 0.0 0.4 14.0 0.0 0.0 0.1 0.0 0.9 0.2 0.6 0.2 0.1 0.8 0.0 0.0 2.8 0.0 0.8 1.0 0.4 0.0 0.0 1.7 1.6 0.0 0.3 0.0 0.0 1.6 0.1 0.0 0.2 0.5 0.0 0.0 0.4 0.1 6.8 9.2 0.6 0.0 0.5 32.0 5.4 0.1 1.0 42.0 0.2 54.8 0.2 21.1 20.2 0.2 0.1 53.2 37.0 2.4 152.3 0.3 0.6 17.6 36.3 0.1 0.0 0.0 0.4 0.0 0.5 1.2 0.2 1.5 0.2 0.8 0.2 0.7 0.0 1.8 0.3 3.2 0.4 0.6 0.0 0.6 0.5 0.8 0.4 1.1 1.5 0.0 0.0 4.2 0.4 84.1 0.2 1.9 1.5 10.1 2.0 0.4 0.9 0.0 10.7 21.5 0.0 0.1 0.6 0.0 5.5 1.3 0.1 3.6 1.5 1.6 0.0 3.3 0.2 0.0 6.9 0.4 2.8 0.3 1.9 1.8 3.7 1.6 1.4 288.4 0.5 0.5 0.1 0.1 0.0 8.9 0.6 0.4 0.5 0.0 0.4 0.0 1.2 0.1 1.0 0.8 0.8 1.1 0.5 52.3 0.1 0.4 0.8 TYK2 JTK1 ENSG00000105397 "Tyrosine kinase 2" P29597 19 10350529-10380572 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal tubular cells: 52.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "NB-4: 206.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005157 Uncertain Approved Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Cytosol "HPA005157: AB_1858480" "unprognostic (1.60e-2)" "unprognostic (6.12e-3)" "unprognostic (3.67e-2)" "prognostic favorable (9.62e-4)" "unprognostic (7.61e-2)" "prognostic favorable (1.05e-5)" "unprognostic (1.20e-2)" "unprognostic (6.16e-3)" "unprognostic (4.93e-2)" "unprognostic (1.90e-2)" "prognostic favorable (1.02e-4)" "unprognostic (1.24e-2)" "prognostic unfavorable (4.43e-4)" "unprognostic (2.10e-3)" "unprognostic (1.78e-1)" "unprognostic (4.19e-1)" "prognostic favorable (4.16e-4)" 53.0 60.5 69.9 37.0 71.9 82.6 52.5 70.7 82.3 55.8 72.2 51.5 29.4 44.8 22.6 46.2 49.0 26.2 65.0 69.6 68.8 77.3 111.2 72.6 51.5 75.1 71.4 56.4 65.1 28.6 66.2 20.1 71.5 64.5 25.7 25.2 50.8 20.6 41.3 51.1 73.9 23.5 70.2 140.8 54.6 16.6 71.8 54.4 60.2 33.7 51.8 49.3 46.0 76.4 29.1 41.1 24.1 38.0 31.9 44.2 23.5 38.9 39.1 48.1 52.2 31.5 18.7 44.5 44.5 43.4 32.8 28.4 29.4 45.5 24.2 78.0 45.5 81.4 90.5 80.2 49.4 34.4 89.4 43.2 31.3 54.5 32.2 29.9 46.5 56.6 35.0 116.1 42.3 90.1 50.7 206.9 7.7 28.4 71.8 49.9 21.1 45.1 40.0 90.1 22.4 28.0 37.6 38.6 28.1 18.4 21.5 57.2 41.1 61.7 22.7 74.1 45.9 97.2 81.4 40.2 32.4 70.8 36.6 9.8 20.8 27.2 12.8 15.2 7.9 7.5 7.6 11.6 23.5 8.0 5.0 7.1 33.0 8.6 15.7 13.0 10.1 13.0 69.9 71.9 70.7 82.3 69.6 68.8 75.1 71.4 71.5 70.2 71.8 76.4 18.6 12.8 17.9 13.1 17.5 6.6 5.4 7.6 13.1 9.2 10.3 11.0 25.7 11.5 11.1 9.2 4.2 7.0 23.2 14.6 52.8 7.6 2.1 10.2 12.6 12.8 4.8 8.6 10.4 11.1 9.7 11.1 27.0 12.0 19.6 17.1 15.4 27.1 14.6 0.0 9.2 8.7 8.2 28.2 14.6 8.8 7.5 30.8 16.0 12.2 25.3 8.7 17.5 11.1 11.1 11.8 12.9 9.8 19.5 5.9 12.1 29.0 11.2 11.0 0.0 10.5 12.6 1.5 4.5 8.8 7.2 6.7 19.4 13.6 11.1 6.3 TYRO3 "Brt, Dtk, Etk-2, Rek, RSE, Sky, Tif" ENSG00000092445 "TYRO3 protein tyrosine kinase" Q06418 15 41557675-41583589 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion, Host-virus interaction" "Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 32.0;ovary: 49.7" "Cell type enhanced" "Detected in many" "Excitatory neurons: 42.4;Leydig cells: 44.4;Oligodendrocyte precursor cells: 29.1;Oligodendrocytes: 46.8;Peritubular cells: 47.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 1.5" "Lineage enriched" "Detected in single" 4 "granulocytes: 1.5" "Cell line enhanced" "Detected in many" "BEWO: 69.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA071245 Approved NA NA 17000000 "Cluster 33: Neutrophils - Chromatin organization" "Cluster 21: Non-specific - Transcription" "Cluster 28: BEWO - Transcription regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA071245: AB_2686371" "unprognostic (1.26e-1)" "unprognostic (6.34e-2)" "unprognostic (1.47e-1)" "unprognostic (2.68e-1)" "unprognostic (3.29e-1)" "unprognostic (6.77e-2)" "unprognostic (1.56e-3)" "unprognostic (5.41e-2)" "unprognostic (3.72e-1)" "unprognostic (3.21e-1)" "unprognostic (2.69e-1)" "unprognostic (1.37e-1)" "unprognostic (1.92e-10)" "unprognostic (7.59e-2)" "unprognostic (5.22e-1)" "unprognostic (4.04e-3)" "unprognostic (1.84e-2)" 21.5 3.5 18.2 1.4 30.3 0.8 5.2 17.7 27.1 2.1 0.0 2.3 1.6 4.6 3.5 13.1 11.5 2.5 2.2 27.7 10.7 11.3 0.8 3.3 1.3 20.9 22.6 49.7 9.8 0.9 0.9 5.7 18.6 2.6 0.9 2.6 1.9 6.1 0.9 13.8 2.4 4.4 14.4 5.5 3.2 18.8 15.7 0.4 1.1 1.8 3.7 2.1 4.1 32.0 10.3 6.7 20.7 22.7 18.9 12.8 69.2 14.6 9.3 14.2 13.1 37.7 3.4 0.4 18.3 11.9 19.9 23.7 23.3 3.6 6.5 5.8 15.5 3.2 20.2 18.1 13.3 5.2 0.4 4.1 7.3 10.9 3.6 5.8 10.6 9.8 19.1 4.3 7.9 9.8 2.4 1.0 47.7 16.0 6.7 31.9 18.6 3.8 1.2 19.7 24.6 7.0 13.7 21.6 16.3 29.8 17.8 6.0 8.4 28.0 12.2 21.0 22.5 1.7 3.5 3.1 17.2 33.8 17.2 1.1 0.2 0.2 0.1 0.1 0.1 0.2 0.1 0.2 0.1 0.3 0.2 0.2 1.5 0.3 0.1 0.3 0.1 0.1 18.2 30.3 17.7 27.1 27.7 10.7 20.9 22.6 18.6 14.4 15.7 32.0 3.4 3.2 1.1 17.6 0.9 6.8 8.5 0.4 0.6 2.7 2.2 2.2 2.9 2.8 0.7 3.7 6.2 2.9 1.1 1.3 0.0 3.9 3.6 1.1 13.0 5.4 1.8 0.0 42.4 3.6 10.2 10.5 8.6 1.9 0.0 7.6 9.7 0.4 1.2 0.0 4.6 0.9 0.0 1.9 1.3 5.1 44.4 0.9 8.8 1.0 0.1 8.3 1.0 29.1 46.8 4.6 0.1 47.0 0.3 6.4 1.2 1.2 0.5 4.0 0.0 3.9 4.3 4.0 6.5 4.2 10.9 18.9 0.7 5.8 2.3 5.7 YES1 "c-yes, HsT441, Yes" ENSG00000176105 "YES proto-oncogene 1, Src family tyrosine kinase" P07947 18 721588-812546 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 9 "basophil: 20.2" "Lineage enriched" "Detected in many" 9 "granulocytes: 20.2" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004370, HPA026480" Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Plasma membrane, Cytosol" "CAB004370: AB_627370, HPA026480: AB_1858921" "unprognostic (3.28e-1)" "unprognostic (1.62e-2)" "unprognostic (5.87e-2)" "unprognostic (2.47e-2)" "unprognostic (6.24e-2)" "unprognostic (4.24e-2)" "unprognostic (6.01e-2)" "unprognostic (1.03e-2)" "unprognostic (1.95e-2)" "unprognostic (1.85e-3)" "prognostic unfavorable (2.46e-4)" "unprognostic (2.14e-1)" "unprognostic (8.12e-2)" "unprognostic (4.65e-2)" "unprognostic (1.81e-1)" "unprognostic (4.79e-2)" "unprognostic (4.11e-1)" 25.2 13.5 11.9 10.5 12.7 4.1 21.8 12.7 14.3 17.4 11.5 21.8 24.8 16.0 17.9 22.7 13.9 18.9 13.1 11.7 13.7 27.9 50.6 17.2 6.2 13.9 13.2 12.4 26.5 20.0 6.1 41.7 13.5 15.0 22.7 8.3 21.0 11.9 8.3 16.7 23.7 15.9 14.2 27.4 21.3 19.0 14.3 10.5 22.0 14.6 8.8 20.3 11.5 14.1 42.7 20.8 64.3 50.6 37.8 46.5 75.6 27.9 56.2 32.0 43.7 49.9 30.7 0.1 28.8 47.3 41.0 24.3 60.8 49.1 62.3 0.2 20.7 12.6 19.4 35.1 30.6 9.9 21.7 35.7 51.7 48.5 53.6 39.8 109.8 7.0 56.1 18.4 46.1 29.3 6.0 13.0 40.9 26.0 26.4 7.4 50.6 3.6 46.8 49.6 13.1 15.3 57.5 42.9 37.1 42.3 29.7 20.5 95.6 78.4 86.2 59.9 75.8 15.7 8.3 2.6 29.7 13.8 47.6 20.2 0.0 1.0 2.2 0.0 1.5 0.1 0.4 1.2 0.0 0.0 1.0 1.7 0.0 1.1 0.0 0.0 0.1 0.6 11.9 12.7 12.7 14.3 11.7 13.7 13.9 13.2 13.5 14.2 14.3 14.1 120.3 25.6 36.8 18.9 3.3 60.2 46.8 21.4 50.1 6.0 38.1 26.7 18.2 24.3 31.3 29.5 6.2 37.1 52.9 40.3 3.9 29.6 29.4 32.8 35.0 91.0 22.8 12.0 0.4 39.2 26.6 35.4 57.6 43.6 13.9 35.9 39.7 44.9 4.9 3.3 10.3 37.2 14.2 5.4 14.7 11.7 18.3 5.0 24.9 46.9 2.0 16.8 16.5 31.7 30.2 51.0 28.8 12.8 28.9 65.4 33.1 45.6 29.0 8.6 19.7 35.9 23.8 20.3 13.6 53.1 49.7 45.6 27.5 42.4 36.7 66.6 ZAP70 "SRK, STD, ZAP-70" ENSG00000115085 "Zeta chain of T cell receptor associated protein kinase 70" P43403 2 97713576-97739862 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Adaptive immunity, Immunity" "Kinase, Transferase, Tyrosine-protein kinase" "Disease variant, SCID" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 24.8;lymphoid tissue: 79.9" "Group enriched" "Detected in many" 4 "dendritic cells: 101.0;NK-cells: 155.5;T-cells: 105.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Group enriched" "Detected in many" 41 "gdT-cell: 137.4;MAIT T-cell: 93.2;memory CD4 T-cell: 71.7;memory CD8 T-cell: 108.3;naive CD4 T-cell: 50.8;naive CD8 T-cell: 79.8;NK-cell: 112.2;T-reg: 80.1" "Group enriched" "Detected in many" 56 "NK-cells: 112.2;T-cells: 137.4" "Group enriched" "Detected in some" 11 "JURKAT: 121.0;MOLT-4: 183.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB002625, HPA003134" Enhanced NA NA 14000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 3: T-cells - Adaptive immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 63: NK-cells & T-cells - Immune response" "CAB002625: , HPA003134: AB_1080629" "unprognostic (4.11e-3)" "prognostic favorable (6.89e-5)" "unprognostic (3.82e-3)" "prognostic favorable (9.66e-8)" "unprognostic (5.78e-2)" "prognostic favorable (3.93e-6)" "unprognostic (2.30e-3)" "unprognostic (1.09e-3)" "unprognostic (3.30e-1)" "unprognostic (1.37e-2)" "unprognostic (9.23e-3)" "unprognostic (2.70e-1)" "prognostic unfavorable (3.02e-8)" "unprognostic (1.29e-1)" "unprognostic (1.65e-1)" "unprognostic (6.40e-2)" "unprognostic (5.83e-3)" 3.3 1.3 0.5 28.0 0.6 24.8 1.9 0.5 0.9 1.7 0.7 4.0 5.8 1.4 0.5 2.3 2.2 5.4 1.4 0.5 0.7 2.8 3.9 8.7 57.0 0.8 1.3 0.8 1.0 0.4 1.1 0.9 0.7 2.5 1.5 0.0 2.3 0.8 2.0 2.4 18.5 0.5 0.6 35.5 6.7 2.7 1.2 79.9 3.5 2.8 17.7 4.9 2.5 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.4 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.0 121.0 0.0 0.7 0.0 0.0 183.4 0.5 0.1 0.0 0.0 7.2 0.1 9.1 0.0 0.0 0.2 0.2 0.0 0.2 0.1 0.6 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 14.1 0.1 0.0 0.0 0.3 0.3 0.5 137.4 0.4 93.2 0.2 71.7 108.3 0.3 1.6 50.8 79.8 2.2 112.2 1.0 0.9 80.1 64.2 0.5 0.6 0.5 0.9 0.5 0.7 0.8 1.3 0.7 0.6 1.2 0.6 0.8 9.6 13.6 0.3 3.9 1.5 0.0 0.0 0.0 0.0 0.8 0.5 3.0 0.0 0.0 0.0 0.0 0.1 101.0 0.2 1.9 0.2 1.0 1.6 0.5 0.8 0.0 8.8 0.2 0.0 0.0 1.8 4.6 0.4 2.5 0.1 2.5 0.7 2.2 0.0 0.2 0.0 0.0 2.8 2.2 0.7 0.0 3.4 1.8 2.8 5.0 0.0 155.5 0.0 0.1 0.0 0.0 0.0 28.0 0.1 0.0 0.5 0.0 0.0 0.0 14.3 0.6 1.3 2.1 0.2 1.4 0.0 105.6 0.1 0.1 0.2