Gene	"Gene synonym"	Ensembl	"Gene description"	Uniprot	Chromosome	Position	"Protein class"	"Biological process"	"Molecular function"	"Disease involvement"	Evidence	"HPA evidence"	"UniProt evidence"	"NeXtProt evidence"	"RNA tissue specificity"	"RNA tissue distribution"	"RNA tissue specificity score"	"RNA tissue specific nTPM"	"RNA single cell type specificity"	"RNA single cell type distribution"	"RNA single cell type specificity score"	"RNA single cell type specific nTPM"	"RNA cancer specificity"	"RNA cancer distribution"	"RNA cancer specificity score"	"RNA cancer specific FPKM"	"RNA brain regional specificity"	"RNA brain regional distribution"	"RNA brain regional specificity score"	"RNA brain regional specific nTPM"	"RNA blood cell specificity"	"RNA blood cell distribution"	"RNA blood cell specificity score"	"RNA blood cell specific nTPM"	"RNA blood lineage specificity"	"RNA blood lineage distribution"	"RNA blood lineage specificity score"	"RNA blood lineage specific nTPM"	"RNA cell line specificity"	"RNA cell line distribution"	"RNA cell line specificity score"	"RNA cell line specific nTPM"	"RNA mouse brain regional specificity"	"RNA mouse brain regional distribution"	"RNA mouse brain regional specificity score"	"RNA mouse brain regional specific nTPM"	"RNA pig brain regional specificity"	"RNA pig brain regional distribution"	"RNA pig brain regional specificity score"	"RNA pig brain regional specific nTPM"	Antibody	"Reliability (IH)"	"Reliability (Mouse Brain)"	"Reliability (IF)"	"Subcellular location"	"Secretome location"	"CCD Protein"	"CCD Transcript"	"Blood concentration - Conc. blood IM [pg/L]"	"Blood concentration - Conc. blood MS [pg/L]"	"Blood expression cluster"	"Tissue expression cluster"	"Cell line expression cluster"	"Single cell expression cluster"	"Subcellular main location"	"Subcellular additional location"	"Antibody RRID"	"Pathology prognostics - Breast cancer"	"Pathology prognostics - Cervical cancer"	"Pathology prognostics - Colorectal cancer"	"Pathology prognostics - Endometrial cancer"	"Pathology prognostics - Glioma"	"Pathology prognostics - Head and neck cancer"	"Pathology prognostics - Liver cancer"	"Pathology prognostics - Lung cancer"	"Pathology prognostics - Melanoma"	"Pathology prognostics - Ovarian cancer"	"Pathology prognostics - Pancreatic cancer"	"Pathology prognostics - Prostate cancer"	"Pathology prognostics - Renal cancer"	"Pathology prognostics - Stomach cancer"	"Pathology prognostics - Testis cancer"	"Pathology prognostics - Thyroid cancer"	"Pathology prognostics - Urothelial cancer"	"Tissue RNA - adipose tissue [nTPM]"	"Tissue RNA - adrenal gland [nTPM]"	"Tissue RNA - amygdala [nTPM]"	"Tissue RNA - appendix [nTPM]"	"Tissue RNA - basal ganglia [nTPM]"	"Tissue RNA - bone marrow [nTPM]"	"Tissue RNA - breast [nTPM]"	"Tissue RNA - cerebellum [nTPM]"	"Tissue RNA - cerebral cortex [nTPM]"	"Tissue RNA - cervix [nTPM]"	"Tissue RNA - choroid plexus [nTPM]"	"Tissue RNA - colon [nTPM]"	"Tissue RNA - duodenum [nTPM]"	"Tissue RNA - endometrium 1 [nTPM]"	"Tissue RNA - epididymis [nTPM]"	"Tissue RNA - esophagus [nTPM]"	"Tissue RNA - fallopian tube [nTPM]"	"Tissue RNA - gallbladder [nTPM]"	"Tissue RNA - heart muscle [nTPM]"	"Tissue RNA - hippocampal formation [nTPM]"	"Tissue RNA - hypothalamus [nTPM]"	"Tissue RNA - kidney [nTPM]"	"Tissue RNA - liver [nTPM]"	"Tissue RNA - lung [nTPM]"	"Tissue RNA - lymph node [nTPM]"	"Tissue RNA - medulla oblongata [nTPM]"	"Tissue RNA - midbrain [nTPM]"	"Tissue RNA - ovary [nTPM]"	"Tissue RNA - pancreas [nTPM]"	"Tissue RNA - parathyroid gland [nTPM]"	"Tissue RNA - pituitary gland [nTPM]"	"Tissue RNA - placenta [nTPM]"	"Tissue RNA - pons [nTPM]"	"Tissue RNA - prostate [nTPM]"	"Tissue RNA - rectum [nTPM]"	"Tissue RNA - retina [nTPM]"	"Tissue RNA - salivary gland [nTPM]"	"Tissue RNA - seminal vesicle [nTPM]"	"Tissue RNA - skeletal muscle [nTPM]"	"Tissue RNA - skin 1 [nTPM]"	"Tissue RNA - small intestine [nTPM]"	"Tissue RNA - smooth muscle [nTPM]"	"Tissue RNA - spinal cord [nTPM]"	"Tissue RNA - spleen [nTPM]"	"Tissue RNA - stomach 1 [nTPM]"	"Tissue RNA - testis [nTPM]"	"Tissue RNA - thalamus [nTPM]"	"Tissue RNA - thymus [nTPM]"	"Tissue RNA - thyroid gland [nTPM]"	"Tissue RNA - tongue [nTPM]"	"Tissue RNA - tonsil [nTPM]"	"Tissue RNA - urinary bladder [nTPM]"	"Tissue RNA - vagina [nTPM]"	"Tissue RNA - white matter [nTPM]"	"Cell RNA - A-431 [nTPM]"	"Cell RNA - A549 [nTPM]"	"Cell RNA - AF22 [nTPM]"	"Cell RNA - AN3-CA [nTPM]"	"Cell RNA - ASC diff [nTPM]"	"Cell RNA - ASC TERT1 [nTPM]"	"Cell RNA - BEWO [nTPM]"	"Cell RNA - BJ [nTPM]"	"Cell RNA - BJ hTERT+ [nTPM]"	"Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]"	"Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]"	"Cell RNA - CACO-2 [nTPM]"	"Cell RNA - CAPAN-2 [nTPM]"	"Cell RNA - Daudi [nTPM]"	"Cell RNA - EFO-21 [nTPM]"	"Cell RNA - fHDF/TERT166 [nTPM]"	"Cell RNA - GAMG [nTPM]"	"Cell RNA - HaCaT [nTPM]"	"Cell RNA - HAP1 [nTPM]"	"Cell RNA - HBEC3-KT [nTPM]"	"Cell RNA - HBF TERT88 [nTPM]"	"Cell RNA - HDLM-2 [nTPM]"	"Cell RNA - HEK 293 [nTPM]"	"Cell RNA - HEL [nTPM]"	"Cell RNA - HeLa [nTPM]"	"Cell RNA - Hep G2 [nTPM]"	"Cell RNA - HHSteC [nTPM]"	"Cell RNA - HL-60 [nTPM]"	"Cell RNA - HMC-1 [nTPM]"	"Cell RNA - HSkMC [nTPM]"	"Cell RNA - hTCEpi [nTPM]"	"Cell RNA - hTEC/SVTERT24-B [nTPM]"	"Cell RNA - hTERT-HME1 [nTPM]"	"Cell RNA - hTERT-RPE1 [nTPM]"	"Cell RNA - HUVEC TERT2 [nTPM]"	"Cell RNA - JURKAT [nTPM]"	"Cell RNA - K-562 [nTPM]"	"Cell RNA - Karpas-707 [nTPM]"	"Cell RNA - LHCN-M2 [nTPM]"	"Cell RNA - MCF7 [nTPM]"	"Cell RNA - MOLT-4 [nTPM]"	"Cell RNA - NB-4 [nTPM]"	"Cell RNA - NTERA-2 [nTPM]"	"Cell RNA - OE19 [nTPM]"	"Cell RNA - PC-3 [nTPM]"	"Cell RNA - REH [nTPM]"	"Cell RNA - RH-30 [nTPM]"	"Cell RNA - RPMI-8226 [nTPM]"	"Cell RNA - RPTEC TERT1 [nTPM]"	"Cell RNA - RT4 [nTPM]"	"Cell RNA - SCLC-21H [nTPM]"	"Cell RNA - SH-SY5Y [nTPM]"	"Cell RNA - SiHa [nTPM]"	"Cell RNA - SK-BR-3 [nTPM]"	"Cell RNA - SK-MEL-30 [nTPM]"	"Cell RNA - SuSa [nTPM]"	"Cell RNA - T-47d [nTPM]"	"Cell RNA - THP-1 [nTPM]"	"Cell RNA - TIME [nTPM]"	"Cell RNA - U-138 MG [nTPM]"	"Cell RNA - U-2 OS [nTPM]"	"Cell RNA - U-2197 [nTPM]"	"Cell RNA - U-251 MG [nTPM]"	"Cell RNA - U-266/70 [nTPM]"	"Cell RNA - U-266/84 [nTPM]"	"Cell RNA - U-698 [nTPM]"	"Cell RNA - U-87 MG [nTPM]"	"Cell RNA - U-937 [nTPM]"	"Cell RNA - WM-115 [nTPM]"	"Blood RNA - basophil [nTPM]"	"Blood RNA - classical monocyte [nTPM]"	"Blood RNA - eosinophil [nTPM]"	"Blood RNA - gdT-cell [nTPM]"	"Blood RNA - intermediate monocyte [nTPM]"	"Blood RNA - MAIT T-cell [nTPM]"	"Blood RNA - memory B-cell [nTPM]"	"Blood RNA - memory CD4 T-cell [nTPM]"	"Blood RNA - memory CD8 T-cell [nTPM]"	"Blood RNA - myeloid DC [nTPM]"	"Blood RNA - naive B-cell [nTPM]"	"Blood RNA - naive CD4 T-cell [nTPM]"	"Blood RNA - naive CD8 T-cell [nTPM]"	"Blood RNA - neutrophil [nTPM]"	"Blood RNA - NK-cell [nTPM]"	"Blood RNA - non-classical monocyte [nTPM]"	"Blood RNA - plasmacytoid DC [nTPM]"	"Blood RNA - T-reg [nTPM]"	"Blood RNA - total PBMC [nTPM]"	"Brain RNA - amygdala [nTPM]"	"Brain RNA - basal ganglia [nTPM]"	"Brain RNA - cerebellum [nTPM]"	"Brain RNA - cerebral cortex [nTPM]"	"Brain RNA - hippocampal formation [nTPM]"	"Brain RNA - hypothalamus [nTPM]"	"Brain RNA - medulla oblongata [nTPM]"	"Brain RNA - midbrain [nTPM]"	"Brain RNA - pons [nTPM]"	"Brain RNA - spinal cord [nTPM]"	"Brain RNA - thalamus [nTPM]"	"Brain RNA - white matter [nTPM]"	"Single Cell Type RNA - Adipocytes [nTPM]"	"Single Cell Type RNA - Alveolar cells type 1 [nTPM]"	"Single Cell Type RNA - Alveolar cells type 2 [nTPM]"	"Single Cell Type RNA - Astrocytes [nTPM]"	"Single Cell Type RNA - B-cells [nTPM]"	"Single Cell Type RNA - Basal keratinocytes [nTPM]"	"Single Cell Type RNA - Basal prostatic cells [nTPM]"	"Single Cell Type RNA - Basal respiratory cells [nTPM]"	"Single Cell Type RNA - Basal squamous epithelial cells [nTPM]"	"Single Cell Type RNA - Bipolar cells [nTPM]"	"Single Cell Type RNA - Breast glandular cells [nTPM]"	"Single Cell Type RNA - Breast myoepithelial cells [nTPM]"	"Single Cell Type RNA - Cardiomyocytes [nTPM]"	"Single Cell Type RNA - Cholangiocytes [nTPM]"	"Single Cell Type RNA - Club cells [nTPM]"	"Single Cell Type RNA - Collecting duct cells [nTPM]"	"Single Cell Type RNA - Cone photoreceptor cells [nTPM]"	"Single Cell Type RNA - Cytotrophoblasts [nTPM]"	"Single Cell Type RNA - dendritic cells [nTPM]"	"Single Cell Type RNA - Distal enterocytes [nTPM]"	"Single Cell Type RNA - Distal tubular cells [nTPM]"	"Single Cell Type RNA - Ductal cells [nTPM]"	"Single Cell Type RNA - Early spermatids [nTPM]"	"Single Cell Type RNA - Endometrial ciliated cells [nTPM]"	"Single Cell Type RNA - Endometrial stromal cells [nTPM]"	"Single Cell Type RNA - Endothelial cells [nTPM]"	"Single Cell Type RNA - Enteroendocrine cells [nTPM]"	"Single Cell Type RNA - Erythroid cells [nTPM]"	"Single Cell Type RNA - Excitatory neurons [nTPM]"	"Single Cell Type RNA - Exocrine glandular cells [nTPM]"	"Single Cell Type RNA - Extravillous trophoblasts [nTPM]"	"Single Cell Type RNA - Fibroblasts [nTPM]"	"Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]"	"Single Cell Type RNA - Glandular and luminal cells [nTPM]"	"Single Cell Type RNA - granulocytes [nTPM]"	"Single Cell Type RNA - Granulosa cells [nTPM]"	"Single Cell Type RNA - Hepatic stellate cells [nTPM]"	"Single Cell Type RNA - Hepatocytes [nTPM]"	"Single Cell Type RNA - Hofbauer cells [nTPM]"	"Single Cell Type RNA - Horizontal cells [nTPM]"	"Single Cell Type RNA - Inhibitory neurons [nTPM]"	"Single Cell Type RNA - Intestinal goblet cells [nTPM]"	"Single Cell Type RNA - Ionocytes [nTPM]"	"Single Cell Type RNA - Kupffer cells [nTPM]"	"Single Cell Type RNA - Langerhans cells [nTPM]"	"Single Cell Type RNA - Late spermatids [nTPM]"	"Single Cell Type RNA - Leydig cells [nTPM]"	"Single Cell Type RNA - Macrophages [nTPM]"	"Single Cell Type RNA - Melanocytes [nTPM]"	"Single Cell Type RNA - Microglial cells [nTPM]"	"Single Cell Type RNA - monocytes [nTPM]"	"Single Cell Type RNA - Muller glia cells [nTPM]"	"Single Cell Type RNA - NK-cells [nTPM]"	"Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]"	"Single Cell Type RNA - Oligodendrocytes [nTPM]"	"Single Cell Type RNA - Pancreatic endocrine cells [nTPM]"	"Single Cell Type RNA - Paneth cells [nTPM]"	"Single Cell Type RNA - Peritubular cells [nTPM]"	"Single Cell Type RNA - Plasma cells [nTPM]"	"Single Cell Type RNA - Prostatic glandular cells [nTPM]"	"Single Cell Type RNA - Proximal enterocytes [nTPM]"	"Single Cell Type RNA - Proximal tubular cells [nTPM]"	"Single Cell Type RNA - Respiratory ciliated cells [nTPM]"	"Single Cell Type RNA - Rod photoreceptor cells [nTPM]"	"Single Cell Type RNA - Sertoli cells [nTPM]"	"Single Cell Type RNA - Skeletal myocytes [nTPM]"	"Single Cell Type RNA - Smooth muscle cells [nTPM]"	"Single Cell Type RNA - Spermatocytes [nTPM]"	"Single Cell Type RNA - Spermatogonia [nTPM]"	"Single Cell Type RNA - Squamous epithelial cells [nTPM]"	"Single Cell Type RNA - Suprabasal keratinocytes [nTPM]"	"Single Cell Type RNA - Syncytiotrophoblasts [nTPM]"	"Single Cell Type RNA - T-cells [nTPM]"	"Single Cell Type RNA - Theca cells [nTPM]"	"Single Cell Type RNA - Undifferentiated cells [nTPM]"	"Single Cell Type RNA - Urothelial cells [nTPM]"
BACE1	BACE	ENSG00000186318	"Beta-secretase 1"	P56817	11	117285207-117316259	"Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters"		"Aspartyl protease, Hydrolase, Protease"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Group enriched"	"Detected in all"	4	"brain: 119.1;pancreas: 271.5"	"Cell type enhanced"	"Detected in many"		"Cone photoreceptor cells: 118.9;Early spermatids: 99.9;Late spermatids: 343.0;Oligodendrocytes: 99.8"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Cell line enhanced"	"Detected in many"		"fHDF/TERT166: 88.3"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			CAB016358	Approved		Supported	"Plasma membrane"		NA	NA				"Cluster 22: Non-specific - Unknown function"	"Cluster 34: Mesenchymal cell lines - ECM organization"	"Cluster 31: Spermatids - Spermatogenesis"	"Plasma membrane"		"CAB016358: AB_626716"	"unprognostic (7.96e-3)"	"unprognostic (8.05e-2)"	"unprognostic (3.55e-2)"	"unprognostic (3.05e-3)"	"unprognostic (8.94e-2)"	"unprognostic (3.39e-1)"	"unprognostic (1.03e-1)"	"unprognostic (2.60e-1)"	"unprognostic (4.54e-2)"	"unprognostic (8.04e-2)"	"unprognostic (8.09e-2)"	"unprognostic (1.09e-1)"	"unprognostic (1.12e-1)"	"unprognostic (1.35e-2)"	"unprognostic (1.16e-1)"	"unprognostic (1.27e-1)"	"prognostic unfavorable (6.76e-4)"	15.4	16.0	34.3	8.0	68.5	3.3	11.7	68.7	44.0	18.3	11.9	13.7	6.1	19.7	8.8	13.5	15.9	19.1	11.4	34.3	44.5	14.8	25.6	14.4	5.1	89.7	67.0	20.5	271.5	18.5	10.7	13.8	76.6	13.4	7.6	44.7	11.0	18.3	12.5	11.4	7.7	21.3	61.6	12.4	9.8	11.2	59.9	3.8	12.2	9.1	5.0	12.4	14.3	119.1	11.5	10.7	22.9	37.3	80.9	82.3	1.0	62.9	44.4	24.4	19.0	4.5	16.4	1.4	14.6	88.3	18.4	17.9	24.3	12.1	20.5	3.1	12.1	6.0	17.3	5.1	36.5	2.5	1.7	68.1	20.2	29.7	31.8	68.0	21.4	3.8	2.7	1.1	46.5	33.4	2.5	2.1	15.5	10.6	25.9	6.4	11.6	1.6	12.2	5.9	31.7	36.7	22.5	2.6	5.9	23.5	26.2	7.6	31.4	45.2	5.0	48.2	19.4	0.7	1.0	1.1	23.8	2.0	34.0	0.0	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.0	0.0	0.0	34.3	68.5	68.7	44.0	34.3	44.5	89.7	67.0	76.6	61.6	59.9	119.1	12.1	19.2	10.1	16.3	0.3	4.7	4.1	3.4	9.1	53.7	8.7	9.0	8.7	18.6	13.3	5.5	118.9	1.0	0.1	2.0	5.9	7.4	99.9	5.1	32.1	8.3	21.7	1.7	24.9	20.0	1.3	19.5	3.1	8.9	2.5	15.8	6.8	38.6	9.4	57.2	32.0	5.1	2.0	17.2	7.7	343.0	19.3	7.9	3.6	14.0	4.0	17.9	0.0	22.1	99.8	4.3	6.3	22.2	0.1	2.4	1.7	6.3	3.4	55.2	6.6	18.1	14.2	3.4	1.7	10.6	3.4	0.8	1.2	68.0	4.5	3.4
BACE2	"AEPLC, ALP56, CEAP1, DRAP"	ENSG00000182240	"Beta-secretase 2"	Q9Y5Z0	21	41167801-41282530	"Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters"		"Aspartyl protease, Hydrolase, Protease"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in many"		"salivary gland: 26.8"	"Cell type enhanced"	"Detected in many"		"Prostatic glandular cells: 290.4;Syncytiotrophoblasts: 514.7"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Group enriched"	"Detected in some"	6	"basophil: 2.9;eosinophil: 5.2"	"Lineage enriched"	"Detected in single"	8	"granulocytes: 5.2"	"Cell line enhanced"	"Detected in many"		"OE19: 73.8;SK-BR-3: 53.3;SK-MEL-30: 52.6;WM-115: 46.2"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA035416	Approved				"Intracellular and membrane"	NA	NA			"Cluster 52: Eosinophils - Transcription"	"Cluster 24: Salivary gland - Salivary secretion"	"Cluster 17: WM-115 - Nervous system development"	"Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling"			"HPA035416: AB_2732467"	"unprognostic (1.71e-2)"	"prognostic unfavorable (1.11e-4)"	"unprognostic (5.23e-2)"	"unprognostic (8.12e-3)"	"prognostic unfavorable (5.86e-4)"	"unprognostic (1.52e-2)"	"unprognostic (2.58e-2)"	"unprognostic (2.64e-3)"	"unprognostic (7.24e-2)"	"unprognostic (2.49e-1)"	"unprognostic (3.46e-2)"	"unprognostic (8.50e-2)"	"unprognostic (1.22e-1)"	"unprognostic (4.04e-1)"	"unprognostic (2.10e-1)"	"unprognostic (2.76e-2)"	"unprognostic (5.83e-2)"	10.0	1.6	2.1	4.3	3.1	0.6	7.7	4.4	2.6	6.1	9.4	7.3	3.5	8.7	1.9	9.4	6.3	8.3	6.2	2.0	4.1	9.8	1.7	4.3	3.1	6.7	3.8	2.7	13.1	2.3	1.5	2.9	5.1	8.3	4.5	0.3	26.8	2.6	2.2	5.0	4.5	4.7	5.5	4.7	22.9	1.0	4.1	1.1	4.6	2.2	3.6	6.7	5.6	8.7	27.4	2.1	12.6	0.0	2.5	2.1	0.1	6.3	0.0	3.9	3.8	0.0	9.6	0.1	12.2	7.1	7.2	8.1	0.0	13.6	1.4	0.0	12.6	6.2	3.3	0.0	1.0	0.0	14.4	5.5	2.8	0.5	2.7	20.9	12.1	6.4	0.0	0.1	6.0	6.1	3.4	0.0	8.5	73.8	12.1	1.0	0.0	9.8	11.5	2.5	0.4	0.1	0.5	53.3	52.6	1.0	12.0	0.1	15.8	7.3	5.3	6.5	10.9	0.1	0.1	0.0	17.8	0.0	46.2	2.9	0.0	5.2	0.0	0.0	0.0	0.6	0.0	0.0	0.0	0.4	0.0	0.0	0.0	0.2	0.0	0.0	0.0	0.0	2.1	3.1	4.4	2.6	2.0	4.1	6.7	3.8	5.1	5.5	4.1	8.7	55.0	12.8	15.9	11.8	28.6	18.5	91.6	25.6	42.7	0.8	40.3	33.8	9.7	123.0	72.5	20.2	2.1	127.6	0.5	40.5	93.9	146.3	24.3	65.4	19.8	90.2	18.5	22.1	11.7	105.2	64.2	34.0	186.6	115.8	90.7	6.7	35.3	1.0	28.0	0.0	7.5	86.2	44.7	17.0	8.2	16.0	14.3	3.6	179.7	20.6	2.9	3.1	0.0	9.5	46.0	86.6	23.9	18.8	3.2	290.4	7.3	1.4	76.5	0.8	0.0	15.9	23.6	0.6	1.4	43.5	11.8	514.7	6.2	8.7	56.6	134.2
CTSD	"CLN10, CPSD"	ENSG00000117984	"Cathepsin D"	P07339	11	1752752-1764573	"Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins"		"Aspartyl protease, Hydrolase, Protease"	"Alzheimer disease, Cancer-related genes, Disease variant, Neurodegeneration, Neuronal ceroid lipofuscinosis"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in all"		"Distal enterocytes: 1475.9;Hofbauer cells: 3763.5;Macrophages: 1512.6;Proximal enterocytes: 1699.4"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Cell line enhanced"	"Detected in all"		"CAPAN-2: 2596.6;hTERT-RPE1: 2780.1;SK-BR-3: 2488.5"									"CAB000109, HPA003001"	Supported				"Secreted to blood"	NA	NA		370000000	"Cluster 25: Monocytes - Inflammatory response"	"Cluster 55: Non-specific - Mitochondria & Proteasome"	"Cluster 42: Epithelial cell lines - Epithelial cell function"	"Cluster 4: Macrophages - Innate immune response"			"CAB000109: , HPA003001: AB_1078404"	"unprognostic (9.95e-2)"	"unprognostic (1.62e-1)"	"prognostic unfavorable (2.46e-4)"	"unprognostic (1.09e-1)"	"unprognostic (1.71e-3)"	"unprognostic (2.65e-2)"	"unprognostic (9.40e-3)"	"unprognostic (1.11e-1)"	"unprognostic (1.52e-1)"	"unprognostic (1.12e-3)"	"unprognostic (1.59e-1)"	"unprognostic (1.86e-2)"	"prognostic favorable (4.93e-5)"	"unprognostic (8.98e-2)"	"unprognostic (3.39e-2)"	"unprognostic (2.13e-2)"	"unprognostic (1.60e-1)"	318.6	734.6	147.0	204.9	181.9	499.0	244.0	186.0	156.5	270.8	672.7	298.0	387.6	170.7	82.8	319.4	171.6	438.4	444.1	187.8	223.6	691.6	464.8	539.6	241.0	247.6	206.6	130.7	284.8	137.3	131.5	180.7	228.6	138.2	153.4	48.3	422.1	231.7	590.3	340.9	398.3	105.0	188.9	442.0	287.2	88.9	334.4	78.1	182.1	178.2	123.1	296.4	307.5	367.1	204.6	578.9	51.4	246.2	586.5	206.3	112.1	149.4	362.2	161.8	182.8	147.5	2596.6	49.2	376.8	285.8	1265.6	1072.2	63.7	142.6	35.8	206.7	222.9	70.4	92.5	196.5	736.2	171.4	787.7	350.9	621.6	82.5	136.9	2780.1	128.2	62.1	89.2	267.6	263.3	832.6	47.0	110.9	153.1	719.7	247.9	62.5	72.5	191.2	586.6	610.8	84.2	94.8	173.3	2488.5	535.0	68.6	1022.8	232.6	170.3	556.8	92.9	79.0	216.7	432.0	382.3	26.8	867.7	468.6	509.6	211.2	578.7	170.1	156.5	309.9	90.6	28.8	72.1	110.3	144.5	18.8	82.5	107.4	319.5	192.3	265.2	120.3	89.2	489.1	147.0	181.9	186.0	156.5	187.8	223.6	247.6	206.6	228.6	188.9	334.4	367.1	139.3	112.2	228.6	48.3	62.8	72.0	223.5	473.2	71.7	168.6	108.9	113.8	251.9	314.5	459.5	548.1	110.5	211.7	156.1	1475.9	109.5	911.4	3.3	118.1	67.4	128.3	159.6	132.6	18.3	370.1	165.0	157.0	237.5	203.4	474.3	119.4	695.7	678.9	3763.5	264.2	25.2	418.2	498.5	1187.8	67.5	14.6	108.4	1512.6	227.7	20.6	382.6	179.0	256.4	27.2	42.2	392.3	832.5	128.2	122.5	111.7	1699.4	311.8	270.3	102.1	111.7	70.7	135.2	26.6	63.5	141.2	82.1	471.3	155.0	96.0	399.1	357.8
CTSE		ENSG00000196188	"Cathepsin E"	P14091	1	206008535-206023909	"Enzymes, Metabolic proteins, Predicted intracellular proteins"		"Aspartyl protease, Hydrolase, Protease"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in many"	5	"stomach 1: 1168.3"	"Cell type enhanced"	"Detected in some"		"Alveolar cells type 1: 105.8;Exocrine glandular cells: 262.8;Gastric mucus-secreting cells: 553.5;Pancreatic endocrine cells: 260.0;Paneth cells: 208.9"	"Cancer enhanced"	"Detected in many"		"pancreatic cancer: 297.4;stomach cancer: 200.8"	"Not detected"	"Not detected"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Cell line enriched"	"Detected in some"	46	"OE19: 1799.1"	"Not detected"	"Not detected"							"HPA012674, HPA012940, CAB032687"	Enhanced		Approved	Vesicles	"Intracellular and membrane"	NA	NA				"Cluster 4: Stomach - Digestion"	"Cluster 21: OE19 - Mitochondria"	"Cluster 16: Pancreatic endocrine cells - Mixed function"	Vesicles		"CAB032687: AB_637901, HPA012674: , HPA012940: AB_2668773"	"unprognostic (1.17e-2)"	"unprognostic (2.45e-1)"	"unprognostic (1.31e-2)"	"unprognostic (2.72e-2)"		"unprognostic (1.35e-2)"	"unprognostic (2.52e-3)"	"unprognostic (1.45e-1)"	"unprognostic (3.29e-2)"	"unprognostic (2.87e-2)"	"unprognostic (1.20e-2)"	"unprognostic (1.39e-1)"	"unprognostic (6.37e-3)"	"unprognostic (1.42e-1)"	"unprognostic (5.45e-2)"	"unprognostic (2.61e-2)"	"prognostic favorable (5.26e-5)"	0.3	0.0	0.1	9.5	0.1	30.0	0.0	0.5	0.3	0.0	0.1	15.3	229.8	0.3	1.7	0.8	1.1	15.0	0.3	0.1	0.1	0.2	0.2	49.7	0.5	0.3	0.1	0.1	3.7	0.0	1.1	1.3	0.3	0.2	25.7	0.1	0.0	1.6	0.0	0.1	55.5	0.3	0.1	0.6	1168.3	0.1	0.3	0.5	8.9	0.0	10.7	5.8	0.2	0.5	0.3	0.0	0.0	0.0	0.0	0.0	20.2	0.0	0.0	0.0	0.0	0.8	0.8	0.0	3.8	0.0	0.7	0.6	0.0	0.0	0.0	0.0	0.0	0.7	0.2	2.4	0.0	1.0	3.9	0.0	0.0	0.0	0.0	0.1	0.0	0.1	0.2	0.1	0.0	0.0	0.8	1.5	0.7	1799.1	0.1	0.4	0.0	0.8	0.7	39.4	0.2	0.5	0.0	0.0	0.4	0.1	0.1	0.1	0.0	0.0	0.7	0.0	0.2	0.3	0.0	0.1	0.0	0.0	0.2	0.5	0.1	0.0	0.1	0.1	0.1	0.2	0.1	0.1	0.1	0.3	0.2	0.1	0.6	0.2	0.1	0.2	0.1	0.0	0.1	0.1	0.5	0.3	0.1	0.1	0.3	0.1	0.3	0.1	0.3	0.5	0.0	105.8	27.9	0.0	0.6	0.0	0.1	0.6	0.0	0.0	0.0	0.0	0.5	10.0	42.3	0.0	0.0	0.0	0.0	34.1	0.0	52.0	0.0	0.3	0.0	0.3	2.4	60.6	0.0	262.8	0.1	14.7	553.5	0.6	0.0	0.0	0.0	0.2	0.2	0.0	0.0	21.1	0.0	0.3	0.0	0.0	0.0	0.9	0.0	0.0	1.6	0.0	0.0	0.0	0.1	260.0	208.9	0.0	0.7	0.1	4.0	0.1	7.3	0.0	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.0	0.5	0.1	10.4	0.4
HM13	"dJ324O17.1, H13, IMP1, IMPAS, PSENL3, PSL3, SPP, SPPL1"	ENSG00000101294	"Histocompatibility minor 13"	Q8TCT9	20	31514410-31577923	"Enzymes, Plasma proteins, Predicted membrane proteins"		"Hydrolase, Protease"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in all"		"Hofbauer cells: 324.9;Plasma cells: 400.6"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA045089, HPA056062"	Enhanced		Supported	"Endoplasmic reticulum"		NA	NA			"Cluster 8: Neutrophils - Inflammatory response"	"Cluster 29: Non-specific - Vesicular transport"	"Cluster 25: RPMI-8226 - Immune response"	"Cluster 55: Plasma cells - Humoral immune response"	"Endoplasmic reticulum"		"HPA045089: AB_10962054, HPA056062: AB_2683022"	"unprognostic (8.03e-2)"	"unprognostic (2.11e-2)"	"unprognostic (5.03e-2)"	"unprognostic (1.59e-1)"	"unprognostic (2.82e-1)"	"unprognostic (5.87e-3)"	"prognostic unfavorable (1.95e-5)"	"unprognostic (2.66e-2)"	"unprognostic (2.14e-2)"	"unprognostic (2.55e-1)"	"unprognostic (2.30e-1)"	"unprognostic (8.10e-2)"	"prognostic unfavorable (4.64e-12)"	"unprognostic (3.77e-2)"	"unprognostic (1.57e-1)"	"unprognostic (1.85e-1)"	"unprognostic (8.17e-2)"	78.6	102.9	10.5	60.9	13.5	61.7	63.4	13.6	15.7	100.0	42.4	54.5	52.6	72.9	111.4	128.6	70.4	46.7	55.9	12.5	17.1	61.4	136.1	83.7	40.7	17.8	17.9	59.2	241.1	68.8	90.0	64.6	17.4	66.0	44.4	20.8	217.7	80.3	44.6	51.6	52.1	49.1	14.2	70.2	92.5	21.9	23.9	30.5	74.7	14.1	54.2	64.9	72.2	20.9	143.8	147.6	56.6	87.7	260.2	163.5	197.6	239.0	221.3	159.7	162.8	287.3	166.8	90.4	312.8	262.7	209.7	253.8	74.9	162.0	97.7	46.2	112.0	201.3	99.7	179.3	287.0	118.1	78.1	152.5	103.5	133.7	182.7	159.0	124.5	56.0	90.2	364.0	148.8	170.3	100.0	84.0	67.8	234.9	248.5	63.6	272.6	436.5	154.4	75.6	76.3	90.4	243.5	234.9	199.2	56.4	182.0	109.5	153.3	243.1	129.8	246.3	136.2	225.5	145.5	71.7	328.7	413.0	219.4	117.7	380.9	190.8	116.7	372.6	159.7	91.9	108.0	112.9	260.8	74.4	70.6	84.1	282.8	117.5	363.7	271.9	104.1	374.1	10.5	13.5	13.6	15.7	12.5	17.1	17.8	17.9	17.4	14.2	23.9	20.9	67.4	51.3	55.4	23.8	78.2	33.4	59.0	127.8	31.3	45.4	65.6	49.1	13.6	71.4	102.2	53.3	123.0	154.0	70.7	115.2	13.7	145.6	15.5	55.0	111.5	60.9	61.5	38.9	40.5	169.7	139.0	93.2	80.0	128.4	42.4	55.5	53.2	86.4	324.9	43.7	39.2	134.5	63.1	81.2	83.1	15.9	60.6	106.1	65.8	28.1	77.4	52.2	53.5	33.7	23.8	144.3	81.2	43.6	400.6	92.4	54.8	51.0	49.3	44.8	32.9	49.2	79.2	26.1	26.4	60.0	35.4	213.6	60.1	97.2	70.8	69.3
NAPSA	"KAP, Kdap, NAP1, NAPA"	ENSG00000131400	"Napsin A aspartic peptidase"	O96009	19	50358477-50365830	"Enzymes, Metabolic proteins, Plasma proteins, Predicted secreted proteins"		"Aspartyl protease, Hydrolase, Protease"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in many"	10	"lung: 1075.5"	"Cell type enriched"	"Detected in many"	5	"Alveolar cells type 2: 3072.3"	"Cancer enriched"	"Detected in many"	18	"lung cancer: 249.9"	"Low region specificity"	"Detected in some"			"Immune cell enhanced"	"Detected in some"		"plasmacytoid DC: 8.7"	"Group enriched"	"Detected in many"	7	"B-cells: 4.3;dendritic cells: 8.7"	"Cell line enriched"	"Detected in some"	31	"U-698: 42.1"	"Not detected"	"Not detected"			"Low region specificity"	"Detected in all"			"CAB009591, HPA045280, HPA047236, HPA047744"	Enhanced				"Secreted in other tissues"	NA	NA		1500000	"Cluster 47: Plasmacytoid DCs - Protein folding"	"Cluster 19: Lung - Lung function"	"Cluster 27: U-698-M & Daudi - Adaptive immune response"	"Cluster 11: Alveolar cells - Smell perception"			"CAB009591: , HPA045280: AB_2679283, HPA047236: AB_2679993, HPA047744: AB_2680143"	"unprognostic (5.36e-2)"	"unprognostic (4.77e-2)"	"unprognostic (1.64e-3)"	"unprognostic (1.78e-1)"	"unprognostic (1.93e-1)"	"unprognostic (4.65e-2)"	"unprognostic (1.02e-1)"	"unprognostic (8.30e-3)"	"unprognostic (2.29e-1)"	"unprognostic (2.23e-2)"	"unprognostic (1.76e-3)"	"unprognostic (7.67e-3)"	"prognostic favorable (1.21e-4)"	"unprognostic (4.08e-4)"	"unprognostic (3.29e-1)"	"unprognostic (9.83e-3)"	"unprognostic (7.26e-5)"	0.4	0.9	0.8	1.6	0.9	0.1	0.5	0.9	0.9	0.7	0.7	0.6	0.4	0.5	2.0	0.4	1.0	0.1	0.4	0.8	0.9	106.3	1.2	1075.5	1.2	0.9	0.8	2.1	1.0	0.2	0.6	0.4	0.9	1.0	0.4	0.4	0.6	1.0	0.2	1.1	1.5	0.1	0.8	1.1	0.9	1.8	1.0	0.4	1.7	0.0	0.5	0.4	0.7	1.1	0.2	0.4	0.0	0.2	0.2	0.2	0.2	0.1	0.0	0.0	0.1	0.1	0.3	0.2	0.3	0.2	0.0	0.5	0.1	0.0	0.0	0.1	0.4	0.0	0.0	0.0	0.2	0.0	0.2	0.4	1.3	0.1	0.0	0.1	0.0	0.0	0.3	0.1	0.0	0.7	0.2	0.5	0.2	0.3	0.4	0.6	0.0	0.2	1.1	0.0	0.0	0.1	0.2	0.0	0.1	0.1	0.1	0.4	0.2	0.0	0.1	1.0	0.0	0.2	0.4	42.1	0.0	0.1	0.0	0.0	0.4	0.0	0.1	0.9	0.0	4.3	0.2	0.3	2.6	1.7	0.4	0.4	0.5	0.4	0.7	8.7	0.0	1.1	0.8	0.9	0.9	0.9	0.8	0.9	0.9	0.8	0.9	0.8	1.0	1.1	0.3	522.4	3072.3	0.3	3.8	0.1	0.5	0.2	0.0	1.3	0.8	0.9	0.4	1.5	45.9	46.0	4.2	0.5	0.4	0.8	9.8	0.6	47.2	12.6	0.4	6.2	0.0	0.4	0.5	0.8	0.3	5.8	0.5	1.5	69.4	1.0	0.4	0.4	0.3	0.0	0.5	1.0	0.0	1.6	5.3	9.1	0.9	7.9	0.0	1.9	0.2	1.5	1.0	0.0	1.4	0.1	2.3	0.4	0.6	0.4	2.0	276.1	16.4	0.9	0.0	0.3	0.3	1.4	1.4	0.0	0.6	0.1	12.9	0.4	0.9	0.1
PGA3		ENSG00000229859	"Pepsinogen A3"	P0DJD8	11	61203307-61213098	"Enzymes, Predicted intracellular proteins, Predicted secreted proteins"	Digestion	"Aspartyl protease, Hydrolase, Protease"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in many"	613	"stomach 1: 89073.4"	"Cell type enriched"	"Detected in some"	526	"Gastric mucus-secreting cells: 3263.5"	"Cancer enriched"	"Detected in single"	498	"stomach cancer: 24.8"	"Region enhanced"	"Detected in single"		"hippocampal formation: 2.9"	"Low immune cell specificity"	"Detected in single"			"Low lineage specificity"	"Detected in single"			"Cell line enhanced"	"Detected in some"		"HMC-1: 2.8;THP-1: 1.1"									"CAB026358, HPA046875"	Enhanced				"Secreted to digestive system"	NA	NA			"Cluster 7: Monocytes - Unknown function"	"Cluster 4: Stomach - Digestion"	"Cluster 3: HMC-1 - Innate immune response"	"Cluster 16: Pancreatic endocrine cells - Mixed function"			"CAB026358: , HPA046875: AB_2679851"										"unprognostic (6.39e-2)"				"unprognostic (1.11e-1)"				80.5	10.0	0.5	0.2	0.2	0.2	18.2	0.7	0.9	11.1	0.0	145.3	1.3	3.8	0.0	96.4	4.5	0.1	11.4	2.9	0.0	5.4	16.2	6.2	0.0	0.0	0.0	5.4	13.0	0.0	13.4	0.5	0.1	5.5	0.1	0.9	6.8	0.7	4.4	6.0	5.7	0.4	0.0	6.3	89073.4	7.3	0.0	0.1	5.0	0.5	0.1	6.2	6.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.6	0.0	0.0	0.0	0.0	0.0	0.3	0.0	0.0	0.3	0.0	0.0	0.0	0.0	0.0	0.2	0.0	0.0	0.0	0.0	2.8	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.3	0.0	0.0	0.0	0.6	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.1	0.0	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.3	0.8	0.1	0.7	1.3	0.4	0.1	0.2	0.7	0.1	0.1	0.1	0.6	0.4	0.2	0.3	0.0	0.0	1.3	0.5	0.2	0.7	0.9	2.9	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.9	0.0	0.2	0.0	0.0	0.5	0.1	0.0	0.9	0.0	0.0	1.8	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.3	0.1	0.0	0.0	0.0	6.2	0.0	0.3	3263.5	0.1	0.0	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.8	0.5	0.0	0.0	0.7	0.0	0.0	0.1	0.2	0.0	0.0	0.0	0.2	0.0	0.0	1.1	0.1	0.0	0.1	0.0	3.1	0.0	0.1	0.1	0.0	0.0	0.0	0.1	0.0	0.4	0.2	0.0	0.1
PGA4		ENSG00000229183	"Pepsinogen A4"	P0DJD7	11	61222349-61231694	"Enzymes, Predicted intracellular proteins, Predicted secreted proteins"	Digestion	"Aspartyl protease, Hydrolase, Protease"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in many"	1281	"stomach 1: 66596.4"	"Cell type enriched"	"Detected in some"	8	"Exocrine glandular cells: 109.1"	"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Group enriched"	"Detected in some"	19	"classical monocyte: 9.9;intermediate monocyte: 10.9;non-classical monocyte: 3.4"	"Lineage enriched"	"Detected in single"	26	"monocytes: 10.9"	"Group enriched"	"Detected in some"	6	"BJ hTERT+: 26.1;HMC-1: 9.5;THP-1: 15.7"									HPA046875	Supported				"Secreted to digestive system"	NA	NA			"Cluster 7: Monocytes - Unknown function"	"Cluster 4: Stomach - Digestion"	"Cluster 3: HMC-1 - Innate immune response"	"Cluster 1: Pancreatic cells - Digestion"			"HPA046875: AB_2679851"										"unprognostic (2.22e-1)"								9.6	8.3	0.1	2.1	0.1	0.0	9.0	0.1	0.2	7.5	0.1	52.0	2.5	4.6	0.0	9.1	19.1	0.3	6.2	0.1	0.1	30.3	11.7	37.9	0.0	0.1	0.1	4.1	18.8	0.0	3.5	3.8	0.1	16.2	0.4	0.3	4.5	0.7	2.5	4.1	2.9	0.8	0.1	5.2	66596.4	4.3	0.1	0.1	3.1	0.0	0.2	5.0	5.1	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	26.1	0.0	0.0	0.0	0.0	0.0	2.6	0.0	0.0	0.8	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.0	0.0	9.5	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.1	2.0	0.0	1.6	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	15.7	0.0	0.0	1.1	0.1	0.0	1.3	0.0	0.0	0.0	0.0	0.0	0.0	9.9	0.0	0.0	10.9	0.0	0.0	0.0	0.0	0.4	0.0	0.0	0.1	0.3	0.0	3.4	0.0	0.0	1.8	0.1	0.1	0.1	0.2	0.1	0.1	0.1	0.1	0.1	0.1	0.1	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.6	0.0	0.0	0.0	0.0	0.0	0.0	109.1	0.0	0.0	13.3	0.0	0.0	0.0	0.0	0.0	0.3	0.0	0.0	0.0	0.0	0.0	0.0	2.6	0.0	0.0	0.0	0.0	0.0	0.8	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.2	0.0	0.2	0.0	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0
PGA5		ENSG00000256713	"Pepsinogen A5"	P0DJD9	11	61241175-61251444	"Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins"	Digestion	"Aspartyl protease, Hydrolase, Protease"	"FDA approved drug targets"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in many"	2014	"stomach 1: 39870.8"	"Cell type enriched"	"Detected in some"	77	"Exocrine glandular cells: 4383.1"	"Cancer enriched"	"Detected in some"	12	"stomach cancer: 15.0"	"Not detected"	"Not detected"			"Group enriched"	"Detected in some"	29	"classical monocyte: 1.8;intermediate monocyte: 4.3;non-classical monocyte: 2.4"	"Lineage enriched"	"Detected in single"	44	"monocytes: 4.3"	"Cell line enriched"	"Detected in some"	19	"BJ hTERT+: 28.8"									HPA046875	Supported				"Secreted to digestive system"	NA	NA			"Cluster 7: Monocytes - Unknown function"	"Cluster 4: Stomach - Digestion"	"Cluster 10: BJ & FHDF - ECM organization"	"Cluster 1: Pancreatic cells - Digestion"			"HPA046875: AB_2679851"				"unprognostic (1.36e-3)"	"unprognostic (2.98e-2)"		"unprognostic (5.83e-3)"			"unprognostic (2.11e-1)"	"unprognostic (4.22e-1)"		"unprognostic (4.36e-2)"	"unprognostic (2.16e-2)"	"unprognostic (1.05e-1)"	"unprognostic (7.10e-2)"		19.7	4.4	0.3	1.1	0.3	0.0	4.5	0.1	0.6	4.0	0.0	6.2	0.6	1.9	0.0	7.0	5.1	0.1	3.5	0.7	0.0	2.4	7.0	5.4	0.0	0.1	0.0	2.6	8.2	0.0	3.8	0.5	0.1	1.8	0.1	1.5	2.5	0.5	1.9	2.1	2.1	0.9	0.0	3.9	39870.8	2.3	0.0	0.2	3.1	0.2	0.1	2.3	2.5	0.0	0.0	0.0	0.1	0.0	0.0	0.1	0.0	0.0	28.8	0.0	0.0	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.3	0.0	0.0	0.0	0.0	1.4	0.0	0.0	0.4	0.0	0.0	0.0	0.1	0.0	0.0	0.5	0.0	0.0	0.0	0.4	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.1	1.0	0.0	0.0	0.0	0.4	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	1.8	0.0	0.0	4.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	2.4	0.0	0.0	0.3	0.3	0.3	0.1	0.6	0.7	0.0	0.1	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.4	0.0	0.0	0.7	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	2.2	0.5	0.0	0.0	0.0	0.0	0.0	0.1	4383.1	0.0	0.1	56.6	0.0	0.0	0.2	0.0	0.0	6.7	0.0	0.0	0.0	0.0	5.1	0.0	1.6	0.9	1.3	0.0	0.0	1.0	25.1	0.0	0.0	0.0	8.2	0.0	0.0	0.0	0.0	0.0	1.9	0.0	0.4	0.0	0.0	0.0	0.0	0.3	0.0	0.0	0.0	0.0	0.1	0.0	0.0
PGC		ENSG00000096088	Progastricsin	P20142	6	41736711-41754109	"Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted secreted proteins, Transporters"	Digestion	"Aspartyl protease, Hydrolase, Protease"	"Cancer-related genes"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in many"	45	"stomach 1: 59821.1"	"Group enriched"	"Detected in some"	10	"Gastric mucus-secreting cells: 5737.5;Pancreatic endocrine cells: 1449.1"	"Cancer enhanced"	"Detected in many"		"stomach cancer: 1050.3"	"Region enhanced"	"Detected in single"		"cerebellum: 1.2"	"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Group enriched"	"Detected in some"	11	"Hep G2: 253.1;OE19: 152.2"	"Not detected"	"Not detected"			"Not detected"	"Not detected"			"HPA031717, HPA031718"	Enhanced		Approved	Nucleoplasm	"Secreted to digestive system"	NA	NA			"Cluster 7: Monocytes - Unknown function"	"Cluster 4: Stomach - Digestion"	"Cluster 37: Hep G2 - Hepatocyte cell processes"	"Cluster 16: Pancreatic endocrine cells - Mixed function"	Nucleoplasm		"HPA031717: AB_10670130, HPA031718: AB_10610148"	"unprognostic (9.18e-2)"	"unprognostic (1.87e-1)"	"unprognostic (9.83e-2)"	"unprognostic (2.27e-1)"	"unprognostic (7.18e-2)"	"unprognostic (2.74e-1)"	"unprognostic (1.47e-1)"	"unprognostic (8.50e-2)"		"unprognostic (1.86e-1)"	"unprognostic (9.23e-2)"	"unprognostic (1.09e-1)"	"unprognostic (1.33e-2)"	"unprognostic (2.92e-1)"	"unprognostic (1.65e-1)"		"unprognostic (8.74e-2)"	19.4	7.0	0.0	0.3	0.1	0.2	6.6	1.2	0.5	6.7	0.0	26.4	1327.3	2.8	0.9	85.5	9.2	2.3	6.2	0.1	0.0	4.9	11.0	378.8	0.3	0.0	0.0	3.9	136.3	0.0	7.4	2.8	0.0	83.9	0.3	0.1	4.6	437.7	2.5	3.4	3.2	0.0	0.0	7.7	59821.1	4.2	0.0	0.1	2.2	0.0	0.3	3.8	4.1	0.4	0.0	0.0	0.0	0.0	0.0	0.0	15.5	0.0	0.1	0.0	0.0	18.4	0.0	0.0	0.6	0.0	0.0	3.4	0.0	0.0	0.0	0.0	0.0	0.0	0.0	253.1	0.0	0.3	6.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.0	0.0	4.5	0.9	5.7	152.2	0.0	2.9	0.0	6.2	0.0	0.2	0.0	0.7	0.0	0.0	0.0	0.3	0.0	2.8	0.0	0.0	3.7	0.1	0.0	4.7	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1	1.2	0.5	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.4	0.0	25.6	335.2	0.0	4.4	0.4	2.8	0.0	0.0	0.0	0.3	0.8	0.3	87.2	5.0	0.0	0.0	1.2	0.0	0.3	0.0	4.6	0.0	0.4	0.0	1.1	0.0	0.0	0.3	131.2	1.5	0.9	5737.5	0.1	10.1	0.0	0.0	0.2	0.1	0.0	0.2	0.0	0.0	0.0	0.0	0.1	0.3	1.7	0.0	0.0	2.0	0.0	0.0	0.0	0.1	1449.1	2.1	0.0	2.4	85.2	0.1	0.2	3.0	0.0	0.0	0.0	0.6	0.0	0.5	0.0	0.0	4.1	2.6	0.0	0.2	4.2
PSEN1	"AD3, FAD, PS1, S182"	ENSG00000080815	"Presenilin 1"	P49768	14	73136418-73223691	"Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters"	"Apoptosis, Cell adhesion, Notch signaling pathway"	"Hydrolase, Protease"	"Alzheimer disease, Amyloidosis, Cancer-related genes, Cardiomyopathy, Disease variant, Neurodegeneration"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enriched"	"Detected in all"	5	"Oligodendrocytes: 395.8"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"CAB006844, HPA030760, HPA067496"	Approved		Supported	"Nucleoplasm,Golgi apparatus,Cell Junctions"		Yes	No			"Cluster 31: Non-specific - Inflammatory response"	"Cluster 45: Intestine - Brush border"	"Cluster 42: Epithelial cell lines - Epithelial cell function"	"Cluster 42: Oligodendrocytes - Myelin sheath organization"	"Golgi apparatus"	"Nucleoplasm, Cell Junctions"	"CAB006844: , HPA030760: AB_10696211, HPA067496: AB_2685853"	"unprognostic (1.67e-1)"	"unprognostic (4.79e-2)"	"unprognostic (7.39e-2)"	"unprognostic (8.68e-3)"	"unprognostic (3.84e-1)"	"unprognostic (5.48e-3)"	"prognostic unfavorable (1.99e-5)"	"unprognostic (1.65e-1)"	"unprognostic (8.99e-2)"	"unprognostic (8.45e-2)"	"unprognostic (1.76e-3)"	"unprognostic (2.74e-1)"	"prognostic favorable (1.52e-8)"	"unprognostic (2.29e-1)"	"unprognostic (2.32e-1)"	"unprognostic (7.12e-3)"	"unprognostic (1.85e-1)"	25.1	22.6	44.3	26.5	80.7	39.6	28.2	62.4	56.0	28.1	48.9	49.5	50.2	25.3	26.9	35.2	22.9	31.7	18.0	47.4	51.6	35.5	31.9	32.1	22.4	73.0	63.8	22.0	22.9	35.1	11.6	43.1	71.5	24.3	46.3	23.4	22.9	23.4	18.4	38.2	49.0	27.1	55.7	22.6	31.0	32.5	60.8	26.2	36.9	23.3	30.7	35.0	19.2	119.1	37.1	55.9	50.6	20.0	68.9	49.9	46.7	52.5	60.1	52.6	66.7	69.9	88.9	23.7	34.1	50.5	43.0	94.9	43.2	40.1	57.3	54.6	26.7	27.1	35.1	34.4	63.8	27.7	50.7	50.4	71.9	44.3	54.4	48.5	43.2	26.2	31.0	46.6	50.0	72.8	21.0	35.7	22.0	64.5	40.4	26.4	42.7	30.2	73.7	76.5	28.1	38.3	57.4	53.0	47.1	45.4	66.3	60.7	45.7	53.1	43.5	44.1	25.3	30.3	47.9	23.7	44.9	32.8	33.3	126.8	94.5	96.3	23.1	106.0	22.6	23.1	22.3	19.0	83.4	31.8	20.7	20.1	129.3	42.8	125.0	43.6	37.0	70.3	44.3	80.7	62.4	56.0	47.4	51.6	73.0	63.8	71.5	55.7	60.8	119.1	22.2	28.9	30.5	35.9	25.8	28.6	24.6	24.7	12.0	17.1	25.0	17.7	12.5	15.7	30.2	23.9	39.6	27.1	30.7	79.1	5.9	27.1	22.9	26.3	26.4	22.3	16.2	12.0	38.9	26.7	29.2	23.7	32.1	47.4	18.3	29.6	15.7	24.6	30.5	13.5	40.2	39.5	24.4	50.5	40.8	12.9	16.4	52.3	16.0	39.4	51.8	13.8	14.4	48.7	395.8	38.2	58.8	15.4	23.6	38.8	76.2	13.0	29.0	28.0	26.3	20.0	19.0	40.2	14.4	20.4	33.0	49.9	21.6	18.6	41.3	51.5
PSEN2	"AD3L, AD4, PS2, STM2"	ENSG00000143801	"Presenilin 2"	P49810	1	226870184-226927726	"Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters"	"Notch signaling pathway"	"Hydrolase, Protease"	"Alzheimer disease, Amyloidosis, Cardiomyopathy, Disease variant, Neurodegeneration"	"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"		"Ionocytes: 36.7;Syncytiotrophoblasts: 45.8"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in many"			"Low lineage specificity"	"Detected in all"			"Low cell line specificity"	"Detected in many"																	NA	NA			"Cluster 14: Monocytes - Unknown function"	"Cluster 50: Non-specific - Ribosome"	"Cluster 33: SK-MEL-30 - Melanocyte processes"	"Cluster 10: Non-specific - Unknown function"				"unprognostic (3.40e-2)"	"unprognostic (4.73e-3)"	"unprognostic (2.94e-1)"	"unprognostic (3.86e-2)"	"unprognostic (6.54e-2)"	"unprognostic (1.64e-3)"	"unprognostic (4.72e-2)"	"unprognostic (1.31e-1)"	"unprognostic (9.98e-2)"	"unprognostic (2.73e-2)"	"unprognostic (8.25e-3)"	"unprognostic (8.53e-3)"	"unprognostic (8.45e-2)"	"unprognostic (1.17e-1)"	"unprognostic (8.36e-2)"	"unprognostic (1.68e-1)"	"unprognostic (1.06e-1)"	11.2	19.8	9.7	7.5	9.8	1.6	10.6	12.5	10.7	9.7	10.7	15.2	10.5	15.9	9.0	10.3	13.4	8.3	14.0	9.4	10.6	13.5	12.6	11.5	8.0	9.8	10.9	12.8	45.5	18.1	17.1	9.0	10.8	14.9	8.1	7.4	13.0	13.6	26.5	10.1	13.8	10.4	8.5	15.6	11.5	13.5	10.7	3.3	9.5	16.7	5.0	13.5	9.7	9.7	14.1	24.5	7.2	21.9	10.0	3.5	10.2	12.4	26.5	16.9	12.9	13.8	21.5	1.0	17.0	16.8	10.5	7.9	12.1	11.9	6.7	13.6	20.7	8.7	10.5	12.0	15.4	7.5	15.7	9.1	13.9	18.9	10.4	11.2	6.9	0.7	18.1	6.4	10.0	14.7	0.4	8.2	20.5	22.0	16.0	0.4	22.6	26.4	15.9	13.4	11.3	18.3	9.7	30.6	51.6	18.4	26.5	13.1	8.5	11.2	8.9	9.9	15.2	25.6	45.0	0.9	21.5	2.5	15.7	37.4	8.7	18.4	4.5	9.7	5.1	7.4	1.5	4.6	11.4	3.1	0.7	2.0	1.6	20.0	30.2	0.8	2.4	5.2	9.7	9.8	12.5	10.7	9.4	10.6	9.8	10.9	10.8	8.5	10.7	9.7	11.0	16.0	10.8	2.6	3.9	1.7	4.5	4.0	1.8	6.2	6.6	4.1	12.9	15.7	4.7	5.5	0.0	15.9	1.3	5.9	1.9	13.0	2.5	4.5	3.0	10.0	6.0	6.1	4.2	18.0	4.1	5.9	7.7	5.2	14.5	10.1	19.2	8.4	17.2	16.8	4.5	5.1	36.7	7.2	6.5	1.3	7.2	8.2	33.8	5.6	18.9	21.2	2.1	2.5	1.5	15.2	7.8	13.2	9.9	5.3	13.8	7.2	4.9	5.8	6.6	9.4	10.6	1.5	6.1	3.8	1.8	45.8	2.9	6.6	4.3	4.6
REN		ENSG00000143839	Renin	P00797	1	204154819-204190324	"Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins"		"Aspartyl protease, Hydrolase, Protease"	"Disease variant, FDA approved drug targets"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in many"	10	"kidney: 162.2"	"Cell type enhanced"	"Detected in some"		"Early spermatids: 6.8;Late spermatids: 28.4;Paneth cells: 5.6;Smooth muscle cells: 10.7;Urothelial cells: 7.0"	"Cancer enriched"	"Detected in many"	8	"renal cancer: 39.4"	"Not detected"	"Not detected"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Cell line enhanced"	"Detected in some"		"A-431: 1.0;BJ: 2.0;HMC-1: 2.6;SK-BR-3: 1.8"	"Not detected"	"Not detected"			"Not detected"	"Not detected"			HPA005131	Approved				"Secreted to blood"	NA	NA	692000	10000		"Cluster 7: Kidney - Transmembrane transport"	"Cluster 3: HMC-1 - Innate immune response"	"Cluster 33: Fibroblasts - ECM organization"			"HPA005131: AB_1079174"	"unprognostic (4.45e-2)"	"unprognostic (3.35e-1)"	"unprognostic (1.62e-1)"	"unprognostic (8.58e-2)"		"unprognostic (2.89e-1)"	"unprognostic (1.23e-2)"	"unprognostic (1.24e-1)"	"unprognostic (1.13e-1)"	"unprognostic (7.20e-3)"	"unprognostic (1.37e-1)"	"unprognostic (1.57e-1)"	"prognostic unfavorable (6.45e-5)"	"unprognostic (1.22e-1)"	"unprognostic (1.70e-1)"	"unprognostic (4.98e-2)"	"unprognostic (6.49e-2)"	1.0	1.4	0.3	0.2	0.9	0.0	0.1	0.0	0.2	4.3	3.2	0.4	0.3	9.6	0.3	0.2	2.3	0.1	1.8	0.2	0.0	162.2	0.7	0.7	0.0	0.3	0.4	16.3	0.0	0.0	0.6	15.2	0.1	0.3	0.2	0.1	0.8	0.8	0.0	0.1	0.1	1.5	0.0	0.1	0.0	0.9	0.2	0.5	0.0	0.0	0.5	5.2	0.3	0.0	1.0	0.0	0.0	0.0	0.1	0.0	0.0	2.0	0.4	0.0	0.0	0.0	0.2	0.0	0.1	0.0	0.0	0.1	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.0	2.6	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.2	0.0	0.0	0.2	0.0	0.0	0.0	0.1	0.3	0.0	0.0	0.0	0.0	0.7	0.1	0.0	0.0	1.8	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.3	0.9	0.0	0.2	0.2	0.0	0.3	0.4	0.1	0.0	0.2	0.0	0.0	0.0	1.5	1.0	0.0	0.0	0.8	0.7	0.0	0.7	0.1	0.0	0.2	0.0	0.3	1.8	0.0	0.3	0.0	0.0	0.0	1.2	6.8	0.2	0.5	0.4	0.0	0.0	0.3	1.1	0.2	2.8	0.0	0.5	0.0	0.0	0.0	0.0	0.5	0.0	0.3	0.0	0.0	0.0	0.0	28.4	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.2	1.0	5.6	0.4	0.0	1.8	0.0	0.0	0.0	0.3	0.0	0.0	10.7	0.3	0.2	0.0	0.0	1.1	0.1	1.3	0.0	7.0
SPPL2A	"IMP3, PSL2"	ENSG00000138600	"Signal peptide peptidase like 2A"	Q8TCT8	15	50702266-50765709	"Enzymes, Plasma proteins, Predicted membrane proteins, Transporters"		"Hydrolase, Protease"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA036062, HPA067304"	Enhanced		Supported	Vesicles		NA	NA			"Cluster 45: Eosinophils - Innate immune response"	"Cluster 8: Non-specific - Mitochondria"	"Cluster 19: HEK293 & PC-3 - Transcription regulation"	"Cluster 53: Intestinal epithelial cells - Unknown function"	Vesicles		"HPA036062: AB_10611670, HPA067304: AB_2685820"	"unprognostic (1.66e-1)"	"unprognostic (1.03e-1)"	"unprognostic (2.70e-1)"	"unprognostic (5.82e-3)"	"unprognostic (3.71e-1)"	"unprognostic (1.70e-1)"	"unprognostic (2.15e-1)"	"unprognostic (1.88e-1)"	"unprognostic (2.22e-2)"	"unprognostic (6.36e-2)"	"unprognostic (2.04e-2)"	"unprognostic (4.00e-2)"	"unprognostic (3.11e-2)"	"unprognostic (2.26e-2)"	"unprognostic (1.44e-2)"	"unprognostic (6.96e-2)"	"unprognostic (3.66e-1)"	41.1	34.7	8.3	57.6	10.9	54.5	32.0	11.1	8.5	36.6	48.6	93.4	79.6	27.9	21.5	26.5	26.8	39.4	37.1	6.8	12.3	57.9	107.0	43.4	40.2	15.3	12.8	13.6	63.7	158.5	13.0	54.1	12.5	29.5	82.8	12.5	44.5	32.6	109.3	25.2	67.6	41.0	11.2	37.3	41.7	18.5	12.1	39.5	35.2	81.8	41.7	51.7	20.9	14.5	57.3	96.9	37.0	49.2	142.3	84.3	58.2	89.1	149.1	80.5	114.1	113.1	64.3	35.1	65.0	176.3	120.7	83.5	45.2	54.3	89.5	72.2	27.5	67.0	61.5	58.9	117.4	42.0	104.5	73.9	98.3	66.8	106.7	59.4	80.2	37.7	51.3	134.2	107.6	131.5	20.1	16.2	15.8	90.8	22.0	24.2	57.3	77.6	109.7	130.4	29.7	33.4	54.0	102.7	63.4	74.0	73.2	81.6	98.9	128.7	51.7	83.7	106.7	54.0	100.2	38.8	58.1	69.4	90.3	48.7	52.3	48.9	27.9	48.6	17.4	18.3	22.3	25.5	37.4	19.2	12.4	20.5	37.7	23.5	56.6	33.1	30.4	50.2	8.3	10.9	11.1	8.5	6.8	12.3	15.3	12.8	12.5	11.2	12.1	14.5	66.2	48.1	35.9	20.5	51.9	43.1	79.1	76.3	37.5	14.8	36.4	21.3	77.5	52.9	44.3	68.0	20.9	136.5	72.7	215.5	23.5	87.1	18.8	107.2	56.6	59.6	38.4	30.3	32.0	167.1	88.3	74.3	52.0	57.3	45.7	20.5	46.8	124.1	85.9	8.4	31.4	86.5	36.7	68.7	55.7	7.0	44.7	83.0	32.0	23.4	134.5	27.5	64.9	25.6	26.2	131.9	127.3	36.5	49.9	92.2	143.0	46.8	41.8	17.2	26.3	88.0	51.6	31.7	15.3	39.3	38.8	204.5	60.6	30.8	76.0	94.1
SPPL2B	"IMP4, KIAA1532, PSL1"	ENSG00000005206	"Signal peptide peptidase like 2B"	Q8TCT7	19	2328615-2355095	"Enzymes, Predicted membrane proteins"		"Hydrolase, Protease"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"		"Gastric mucus-secreting cells: 109.1;Late spermatids: 107.7"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"CAB005592, HPA039292"	Approved		Approved	"Nucleoplasm,Plasma membrane,Centrosome"		NA	NA			"Cluster 3: Plasmacytoid DCs - Unknown function"	"Cluster 71: Testis - DNA repair"	"Cluster 20: HeLa - Mitochondria"	"Cluster 53: Intestinal epithelial cells - Unknown function"	"Nucleoplasm, Plasma membrane"	Centrosome	"CAB005592: AB_325074, HPA039292: AB_2676429"	"unprognostic (4.16e-2)"	"unprognostic (2.97e-2)"	"unprognostic (2.48e-2)"	"prognostic favorable (5.00e-5)"	"unprognostic (2.34e-1)"	"unprognostic (1.54e-3)"	"unprognostic (1.74e-1)"	"unprognostic (7.93e-3)"	"unprognostic (3.00e-1)"	"unprognostic (1.72e-1)"	"prognostic favorable (1.33e-4)"	"unprognostic (3.29e-3)"	"prognostic unfavorable (6.45e-4)"	"unprognostic (2.26e-2)"	"unprognostic (2.45e-1)"	"unprognostic (3.02e-1)"	"unprognostic (3.40e-2)"	23.1	23.2	13.7	16.7	13.6	29.1	27.4	15.5	18.6	28.4	17.4	43.4	41.6	26.4	4.4	22.5	34.0	10.7	21.6	11.8	12.1	35.9	33.0	22.2	20.7	19.2	15.6	27.2	50.7	11.0	63.8	10.4	15.5	32.5	9.2	7.1	27.2	9.8	25.3	28.9	52.6	5.9	13.2	39.1	33.9	63.5	15.1	12.0	40.5	3.1	9.9	21.9	20.9	16.4	16.6	25.9	10.9	19.5	8.8	8.9	27.8	21.1	6.1	7.6	8.1	18.2	18.4	15.7	19.4	9.9	7.1	21.7	3.6	7.3	2.3	18.4	16.0	10.4	44.7	24.9	16.5	18.6	13.1	13.1	8.2	7.2	5.2	11.9	10.7	32.2	17.3	39.0	4.7	18.4	20.2	23.6	20.4	14.7	10.5	33.4	5.8	43.9	8.3	41.0	19.4	18.3	21.2	12.8	16.7	7.1	21.3	30.8	24.3	13.8	9.7	35.3	16.9	51.0	20.1	16.7	17.3	21.4	24.5	11.5	7.7	7.4	6.2	7.7	4.4	8.2	5.6	6.0	9.4	12.5	6.9	7.7	3.3	6.4	5.4	17.0	6.0	6.4	13.7	13.6	15.5	18.6	11.8	12.1	19.2	15.6	15.5	13.2	15.1	16.4	23.6	3.2	17.2	57.1	30.8	0.0	6.5	0.0	8.0	26.1	21.6	21.5	6.0	20.0	5.0	25.8	47.9	50.6	18.8	79.5	1.9	16.6	51.4	39.3	22.2	14.4	40.7	14.5	25.3	11.5	20.8	14.2	109.1	25.5	7.0	39.9	13.2	15.1	11.8	32.0	30.3	63.2	0.0	9.4	0.0	107.7	14.9	10.8	0.0	9.4	8.0	13.2	19.6	39.7	35.2	10.4	49.9	15.8	11.5	7.3	57.8	7.9	10.9	39.4	0.0	15.0	11.7	57.0	13.5	10.8	0.0	42.8	11.0	36.4	49.8	6.0
SPPL2C	IMP5	ENSG00000185294	"Signal peptide peptidase like 2C"	Q8IUH8	17	45844881-45847067	"Enzymes, Predicted membrane proteins"		"Hydrolase, Protease"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in single"	73	"testis: 36.8"	"Group enriched"	"Detected in some"	146	"Early spermatids: 202.7;Late spermatids: 615.6"	"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Not detected"	"Not detected"			HPA077339	Supported					NA	NA				"Cluster 74: Testis - Spermatogenesis"		"Cluster 34: Spermatids - Unknown function"			"HPA077339: "	"unprognostic (6.70e-4)"				"unprognostic (1.34e-1)"													0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.1	0.2	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	36.8	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.2	0.0	0.1	0.2	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.4	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	202.7	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	615.6	2.8	0.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.2	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	1.5	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
SPPL3	"DKFZP586C1324, IMP2, MGC126674, MGC126676, MGC90402, PSL4"	ENSG00000157837	"Signal peptide peptidase like 3"	Q8TCT6	12	120762510-120904358	"Enzymes, Predicted membrane proteins"		"Hydrolase, Protease"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in all"		"Oligodendrocytes: 192.3"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cell line specificity"	"Detected in many"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA004194, HPA059958"	Uncertain		Supported	"Vesicles,Plasma membrane"		NA	NA			"Cluster 6: Non-specific - Transcription"	"Cluster 27: Brain & Skin - Unknown function"	"Cluster 19: HEK293 & PC-3 - Transcription regulation"	"Cluster 40: Granulosa cells - Unknown function"	"Vesicles, Plasma membrane"		"HPA004194: AB_2667171, HPA059958: AB_2684179"	"unprognostic (3.29e-1)"	"unprognostic (2.29e-2)"	"unprognostic (3.39e-2)"	"unprognostic (1.63e-1)"	"unprognostic (2.06e-1)"	"unprognostic (7.96e-3)"	"prognostic unfavorable (1.29e-5)"	"unprognostic (3.17e-2)"	"unprognostic (1.10e-1)"	"unprognostic (1.28e-1)"	"unprognostic (2.48e-1)"	"unprognostic (2.44e-1)"	"unprognostic (2.66e-1)"	"unprognostic (9.34e-2)"	"unprognostic (9.92e-2)"	"unprognostic (7.54e-2)"	"unprognostic (9.40e-2)"	20.9	14.9	25.3	11.9	28.1	20.9	24.2	29.0	27.5	30.0	13.1	26.7	18.2	26.3	15.7	44.3	28.6	18.7	18.1	25.4	30.6	22.8	19.3	20.4	15.9	25.0	26.0	31.4	21.3	49.6	13.9	28.4	26.1	20.6	27.2	15.5	20.2	27.0	15.7	56.5	18.8	29.6	24.1	24.3	15.2	39.0	26.4	32.7	31.2	19.6	27.8	28.6	34.2	31.4	30.0	29.2	43.4	27.4	56.2	37.7	30.5	22.5	66.6	47.4	37.9	30.5	29.9	27.4	0.1	39.4	42.0	35.6	44.8	48.4	48.9	21.9	27.5	23.6	16.2	23.4	59.2	27.4	29.3	38.1	75.9	40.7	38.1	56.0	47.1	41.5	26.5	13.4	41.2	26.3	36.7	22.0	29.2	27.8	20.6	21.6	36.6	19.7	36.8	83.8	29.7	31.9	42.8	19.6	34.7	46.1	58.9	18.7	35.4	21.9	29.5	13.6	17.1	30.9	60.3	26.4	32.5	22.3	36.9	4.8	1.2	1.1	1.3	1.2	1.8	1.3	1.6	1.7	2.1	1.6	1.5	1.7	2.2	1.3	1.1	2.7	1.4	0.7	25.3	28.1	29.0	27.5	25.4	30.6	25.0	26.0	26.1	24.1	26.4	31.4	35.2	19.2	20.8	79.3	25.3	55.1	32.3	29.4	43.3	37.8	35.2	24.1	21.2	20.0	19.8	40.5	27.1	42.0	21.2	47.2	1.9	19.3	8.6	20.9	26.9	33.0	27.1	14.5	97.2	24.7	29.0	33.2	25.0	29.7	4.5	68.7	37.5	33.1	38.3	37.0	112.6	33.7	22.4	38.1	39.3	8.0	28.6	34.5	26.6	79.6	26.6	23.0	16.5	141.3	192.3	22.8	34.9	35.0	22.0	33.4	34.0	18.1	18.1	22.4	13.1	32.3	27.4	55.6	41.1	76.9	84.7	64.6	22.4	35.0	35.4	37.6