Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific nTPM" "RNA single cell type specificity" "RNA single cell type distribution" "RNA single cell type specificity score" "RNA single cell type specific nTPM" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific nTPM" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific nTPM" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific nTPM" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific nTPM" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific nTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific nTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "CCD Protein" "CCD Transcript" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Blood expression cluster" "Tissue expression cluster" "Cell line expression cluster" "Single cell expression cluster" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [nTPM]" "Tissue RNA - adrenal gland [nTPM]" "Tissue RNA - amygdala [nTPM]" "Tissue RNA - appendix [nTPM]" "Tissue RNA - basal ganglia [nTPM]" "Tissue RNA - bone marrow [nTPM]" "Tissue RNA - breast [nTPM]" "Tissue RNA - cerebellum [nTPM]" "Tissue RNA - cerebral cortex [nTPM]" "Tissue RNA - cervix [nTPM]" "Tissue RNA - choroid plexus [nTPM]" "Tissue RNA - colon [nTPM]" "Tissue RNA - duodenum [nTPM]" "Tissue RNA - endometrium 1 [nTPM]" "Tissue RNA - epididymis [nTPM]" "Tissue RNA - esophagus [nTPM]" "Tissue RNA - fallopian tube [nTPM]" "Tissue RNA - gallbladder [nTPM]" "Tissue RNA - heart muscle [nTPM]" "Tissue RNA - hippocampal formation [nTPM]" "Tissue RNA - hypothalamus [nTPM]" "Tissue RNA - kidney [nTPM]" "Tissue RNA - liver [nTPM]" "Tissue RNA - lung [nTPM]" "Tissue RNA - lymph node [nTPM]" "Tissue RNA - medulla oblongata [nTPM]" "Tissue RNA - midbrain [nTPM]" "Tissue RNA - ovary [nTPM]" "Tissue RNA - pancreas [nTPM]" "Tissue RNA - parathyroid gland [nTPM]" "Tissue RNA - pituitary gland [nTPM]" "Tissue RNA - placenta [nTPM]" "Tissue RNA - pons [nTPM]" "Tissue RNA - prostate [nTPM]" "Tissue RNA - rectum [nTPM]" "Tissue RNA - retina [nTPM]" "Tissue RNA - salivary gland [nTPM]" "Tissue RNA - seminal vesicle [nTPM]" "Tissue RNA - skeletal muscle [nTPM]" "Tissue RNA - skin 1 [nTPM]" "Tissue RNA - small intestine [nTPM]" "Tissue RNA - smooth muscle [nTPM]" "Tissue RNA - spinal cord [nTPM]" "Tissue RNA - spleen [nTPM]" "Tissue RNA - stomach 1 [nTPM]" "Tissue RNA - testis [nTPM]" "Tissue RNA - thalamus [nTPM]" "Tissue RNA - thymus [nTPM]" "Tissue RNA - thyroid gland [nTPM]" "Tissue RNA - tongue [nTPM]" "Tissue RNA - tonsil [nTPM]" "Tissue RNA - urinary bladder [nTPM]" "Tissue RNA - vagina [nTPM]" "Tissue RNA - white matter [nTPM]" "Cell RNA - A-431 [nTPM]" "Cell RNA - A549 [nTPM]" "Cell RNA - AF22 [nTPM]" "Cell RNA - AN3-CA [nTPM]" "Cell RNA - ASC diff [nTPM]" "Cell RNA - ASC TERT1 [nTPM]" "Cell RNA - BEWO [nTPM]" "Cell RNA - BJ [nTPM]" "Cell RNA - BJ hTERT+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]" "Cell RNA - CACO-2 [nTPM]" "Cell RNA - CAPAN-2 [nTPM]" "Cell RNA - Daudi [nTPM]" "Cell RNA - EFO-21 [nTPM]" "Cell RNA - fHDF/TERT166 [nTPM]" "Cell RNA - GAMG [nTPM]" "Cell RNA - HaCaT [nTPM]" "Cell RNA - HAP1 [nTPM]" "Cell RNA - HBEC3-KT [nTPM]" "Cell RNA - HBF TERT88 [nTPM]" "Cell RNA - HDLM-2 [nTPM]" "Cell RNA - HEK 293 [nTPM]" "Cell RNA - HEL [nTPM]" "Cell RNA - HeLa [nTPM]" "Cell RNA - Hep G2 [nTPM]" "Cell RNA - HHSteC [nTPM]" "Cell RNA - HL-60 [nTPM]" "Cell RNA - HMC-1 [nTPM]" "Cell RNA - HSkMC [nTPM]" "Cell RNA - hTCEpi [nTPM]" "Cell RNA - hTEC/SVTERT24-B [nTPM]" "Cell RNA - hTERT-HME1 [nTPM]" "Cell RNA - hTERT-RPE1 [nTPM]" "Cell RNA - HUVEC TERT2 [nTPM]" "Cell RNA - JURKAT [nTPM]" "Cell RNA - K-562 [nTPM]" "Cell RNA - Karpas-707 [nTPM]" "Cell RNA - LHCN-M2 [nTPM]" "Cell RNA - MCF7 [nTPM]" "Cell RNA - MOLT-4 [nTPM]" "Cell RNA - NB-4 [nTPM]" "Cell RNA - NTERA-2 [nTPM]" "Cell RNA - OE19 [nTPM]" "Cell RNA - PC-3 [nTPM]" "Cell RNA - REH [nTPM]" "Cell RNA - RH-30 [nTPM]" "Cell RNA - RPMI-8226 [nTPM]" "Cell RNA - RPTEC TERT1 [nTPM]" "Cell RNA - RT4 [nTPM]" "Cell RNA - SCLC-21H [nTPM]" "Cell RNA - SH-SY5Y [nTPM]" "Cell RNA - SiHa [nTPM]" "Cell RNA - SK-BR-3 [nTPM]" "Cell RNA - SK-MEL-30 [nTPM]" "Cell RNA - SuSa [nTPM]" "Cell RNA - T-47d [nTPM]" "Cell RNA - THP-1 [nTPM]" "Cell RNA - TIME [nTPM]" "Cell RNA - U-138 MG [nTPM]" "Cell RNA - U-2 OS [nTPM]" "Cell RNA - U-2197 [nTPM]" "Cell RNA - U-251 MG [nTPM]" "Cell RNA - U-266/70 [nTPM]" "Cell RNA - U-266/84 [nTPM]" "Cell RNA - U-698 [nTPM]" "Cell RNA - U-87 MG [nTPM]" "Cell RNA - U-937 [nTPM]" "Cell RNA - WM-115 [nTPM]" "Blood RNA - basophil [nTPM]" "Blood RNA - classical monocyte [nTPM]" "Blood RNA - eosinophil [nTPM]" "Blood RNA - gdT-cell [nTPM]" "Blood RNA - intermediate monocyte [nTPM]" "Blood RNA - MAIT T-cell [nTPM]" "Blood RNA - memory B-cell [nTPM]" "Blood RNA - memory CD4 T-cell [nTPM]" "Blood RNA - memory CD8 T-cell [nTPM]" "Blood RNA - myeloid DC [nTPM]" "Blood RNA - naive B-cell [nTPM]" "Blood RNA - naive CD4 T-cell [nTPM]" "Blood RNA - naive CD8 T-cell [nTPM]" "Blood RNA - neutrophil [nTPM]" "Blood RNA - NK-cell [nTPM]" "Blood RNA - non-classical monocyte [nTPM]" "Blood RNA - plasmacytoid DC [nTPM]" "Blood RNA - T-reg [nTPM]" "Blood RNA - total PBMC [nTPM]" "Brain RNA - amygdala [nTPM]" "Brain RNA - basal ganglia [nTPM]" "Brain RNA - cerebellum [nTPM]" "Brain RNA - cerebral cortex [nTPM]" "Brain RNA - hippocampal formation [nTPM]" "Brain RNA - hypothalamus [nTPM]" "Brain RNA - medulla oblongata [nTPM]" "Brain RNA - midbrain [nTPM]" "Brain RNA - pons [nTPM]" "Brain RNA - spinal cord [nTPM]" "Brain RNA - thalamus [nTPM]" "Brain RNA - white matter [nTPM]" "Single Cell Type RNA - Adipocytes [nTPM]" "Single Cell Type RNA - Alveolar cells type 1 [nTPM]" "Single Cell Type RNA - Alveolar cells type 2 [nTPM]" "Single Cell Type RNA - Astrocytes [nTPM]" "Single Cell Type RNA - B-cells [nTPM]" "Single Cell Type RNA - Basal keratinocytes [nTPM]" "Single Cell Type RNA - Basal prostatic cells [nTPM]" "Single Cell Type RNA - Basal respiratory cells [nTPM]" "Single Cell Type RNA - Basal squamous epithelial cells [nTPM]" "Single Cell Type RNA - Bipolar cells [nTPM]" "Single Cell Type RNA - Breast glandular cells [nTPM]" "Single Cell Type RNA - Breast myoepithelial cells [nTPM]" "Single Cell Type RNA - Cardiomyocytes [nTPM]" "Single Cell Type RNA - Cholangiocytes [nTPM]" "Single Cell Type RNA - Club cells [nTPM]" "Single Cell Type RNA - Collecting duct cells [nTPM]" "Single Cell Type RNA - Cone photoreceptor cells [nTPM]" "Single Cell Type RNA - Cytotrophoblasts [nTPM]" "Single Cell Type RNA - dendritic cells [nTPM]" "Single Cell Type RNA - Distal enterocytes [nTPM]" "Single Cell Type RNA - Distal tubular cells [nTPM]" "Single Cell Type RNA - Ductal cells [nTPM]" "Single Cell Type RNA - Early spermatids [nTPM]" "Single Cell Type RNA - Endometrial ciliated cells [nTPM]" "Single Cell Type RNA - Endometrial stromal cells [nTPM]" "Single Cell Type RNA - Endothelial cells [nTPM]" "Single Cell Type RNA - Enteroendocrine cells [nTPM]" "Single Cell Type RNA - Erythroid cells [nTPM]" "Single Cell Type RNA - Excitatory neurons [nTPM]" "Single Cell Type RNA - Exocrine glandular cells [nTPM]" "Single Cell Type RNA - Extravillous trophoblasts [nTPM]" "Single Cell Type RNA - Fibroblasts [nTPM]" "Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]" "Single Cell Type RNA - Glandular and luminal cells [nTPM]" "Single Cell Type RNA - granulocytes [nTPM]" "Single Cell Type RNA - Granulosa cells [nTPM]" "Single Cell Type RNA - Hepatic stellate cells [nTPM]" "Single Cell Type RNA - Hepatocytes [nTPM]" "Single Cell Type RNA - Hofbauer cells [nTPM]" "Single Cell Type RNA - Horizontal cells [nTPM]" "Single Cell Type RNA - Inhibitory neurons [nTPM]" "Single Cell Type RNA - Intestinal goblet cells [nTPM]" "Single Cell Type RNA - Ionocytes [nTPM]" "Single Cell Type RNA - Kupffer cells [nTPM]" "Single Cell Type RNA - Langerhans cells [nTPM]" "Single Cell Type RNA - Late spermatids [nTPM]" "Single Cell Type RNA - Leydig cells [nTPM]" "Single Cell Type RNA - Macrophages [nTPM]" "Single Cell Type RNA - Melanocytes [nTPM]" "Single Cell Type RNA - Microglial cells [nTPM]" "Single Cell Type RNA - monocytes [nTPM]" "Single Cell Type RNA - Muller glia cells [nTPM]" "Single Cell Type RNA - NK-cells [nTPM]" "Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]" "Single Cell Type RNA - Oligodendrocytes [nTPM]" "Single Cell Type RNA - Pancreatic endocrine cells [nTPM]" "Single Cell Type RNA - Paneth cells [nTPM]" "Single Cell Type RNA - Peritubular cells [nTPM]" "Single Cell Type RNA - Plasma cells [nTPM]" "Single Cell Type RNA - Prostatic glandular cells [nTPM]" "Single Cell Type RNA - Proximal enterocytes [nTPM]" "Single Cell Type RNA - Proximal tubular cells [nTPM]" "Single Cell Type RNA - Respiratory ciliated cells [nTPM]" "Single Cell Type RNA - Rod photoreceptor cells [nTPM]" "Single Cell Type RNA - Sertoli cells [nTPM]" "Single Cell Type RNA - Skeletal myocytes [nTPM]" "Single Cell Type RNA - Smooth muscle cells [nTPM]" "Single Cell Type RNA - Spermatocytes [nTPM]" "Single Cell Type RNA - Spermatogonia [nTPM]" "Single Cell Type RNA - Squamous epithelial cells [nTPM]" "Single Cell Type RNA - Suprabasal keratinocytes [nTPM]" "Single Cell Type RNA - Syncytiotrophoblasts [nTPM]" "Single Cell Type RNA - T-cells [nTPM]" "Single Cell Type RNA - Theca cells [nTPM]" "Single Cell Type RNA - Undifferentiated cells [nTPM]" "Single Cell Type RNA - Urothelial cells [nTPM]" ABL1 "ABL, c-ABL, JTK7, p150" ENSG00000097007 "ABL proto-oncogene 1, non-receptor tyrosine kinase" P00519 9 130713016-130887675 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Autophagy, Cell adhesion, DNA damage, DNA repair, Endocytosis" "DNA-binding, Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Microglial cells: 71.2;Oligodendrocytes: 116.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002686, HPA027251, HPA027280, HPA028409" Supported Enhanced "Nucleoplasm,Nuclear bodies" Yes No "Cluster 37: B-cells - Transcription" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 1: K-562 - Erythropoiesis" "Cluster 50: Fibroblasts - ECM organization" Nucleoplasm "Nuclear bodies" "CAB002686: , HPA027251: AB_1844453, HPA027280: AB_1844454, HPA028409: AB_10601011" "unprognostic (4.82e-2)" "unprognostic (3.99e-2)" "unprognostic (5.55e-2)" "unprognostic (4.72e-2)" "unprognostic (1.16e-1)" "unprognostic (1.46e-1)" "unprognostic (3.75e-3)" "unprognostic (1.89e-3)" "unprognostic (2.34e-1)" "unprognostic (2.54e-2)" "unprognostic (1.09e-2)" "unprognostic (1.48e-1)" "unprognostic (3.96e-3)" "unprognostic (1.10e-2)" "unprognostic (1.47e-1)" "unprognostic (1.22e-1)" "unprognostic (1.06e-1)" 50.9 30.7 27.4 25.3 38.9 23.4 45.8 33.6 31.4 60.5 40.4 96.4 23.1 63.0 11.6 33.8 55.6 35.7 36.1 26.6 28.3 23.1 17.5 37.3 16.3 39.3 38.5 56.0 24.9 32.5 34.9 26.5 35.8 43.5 26.7 14.2 32.4 33.6 29.4 36.3 45.2 41.2 31.3 23.3 51.6 20.1 34.9 22.4 46.7 30.8 15.4 79.3 42.7 41.3 22.5 48.3 53.6 62.9 76.5 93.3 18.8 38.8 60.4 44.8 38.1 36.4 28.3 32.3 22.3 52.0 47.6 42.5 23.5 36.0 30.7 20.6 16.3 23.7 84.1 33.4 51.8 36.5 32.3 68.8 37.2 80.6 50.0 64.1 61.0 47.9 135.8 26.5 54.9 42.0 49.2 30.5 57.9 34.3 33.8 55.9 67.9 35.9 45.0 25.7 47.9 60.1 66.1 23.5 29.2 31.0 46.2 33.1 71.1 170.7 44.1 66.3 62.6 8.4 20.3 47.9 72.1 27.6 55.1 0.0 0.7 0.3 0.6 0.4 0.8 1.3 0.6 0.6 0.7 0.4 0.6 0.5 0.0 0.8 1.9 1.0 0.3 0.6 27.4 38.9 33.6 31.4 26.6 28.3 39.3 38.5 35.8 31.3 34.9 41.3 16.2 9.6 13.6 54.9 4.7 9.2 7.3 9.8 5.2 8.2 11.6 10.2 6.2 7.2 7.2 14.7 12.5 13.6 12.1 21.2 1.9 14.4 5.9 8.6 29.7 18.1 22.1 4.6 52.5 11.1 4.3 36.7 5.6 12.4 2.5 22.1 20.3 15.9 16.6 10.1 63.7 17.5 6.1 16.4 11.7 8.8 28.0 10.2 5.4 71.2 6.6 19.2 6.2 66.9 116.0 17.9 18.3 25.6 5.6 8.6 11.6 10.3 7.8 9.1 19.7 29.5 19.8 16.9 16.5 6.6 6.8 15.2 7.9 20.1 21.4 7.2 AFF1 "AF-4, AF4, MLLT2, PBM1" ENSG00000172493 "AF4/FMR2 family member 1" P51825 4 86935002-87141054 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 225.2;Microglial cells: 202.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA069947 Approved Nucleoplasm,Mitochondria No No "Cluster 1: Neutrophils - Mixed function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 29: U-266 - Adaptive immune response" "Cluster 9: Photoreceptor cells - Phototransduction" "Nucleoplasm, Mitochondria" "HPA069947: AB_2686219" "unprognostic (1.01e-1)" "unprognostic (7.56e-2)" "unprognostic (2.57e-3)" "unprognostic (1.53e-1)" "unprognostic (1.33e-1)" "unprognostic (1.55e-2)" "unprognostic (1.79e-1)" "unprognostic (6.23e-2)" "unprognostic (6.09e-2)" "unprognostic (7.13e-2)" "unprognostic (1.24e-1)" "unprognostic (8.32e-3)" "unprognostic (5.86e-2)" "unprognostic (1.33e-2)" "unprognostic (4.41e-1)" "unprognostic (2.55e-1)" "unprognostic (2.71e-2)" 33.2 18.0 10.7 18.1 11.8 35.0 22.8 8.1 13.0 24.8 51.4 25.9 18.2 25.6 11.8 19.1 21.4 19.6 19.6 10.2 10.0 32.8 24.8 20.7 16.3 16.3 9.8 28.8 28.2 31.8 12.5 26.8 11.8 18.2 22.5 63.6 24.0 22.8 55.6 23.4 19.4 31.9 9.1 19.4 19.0 6.9 14.2 22.8 54.9 41.8 13.4 18.5 19.0 12.0 15.3 13.5 11.3 12.0 18.3 21.6 15.9 15.1 22.2 11.3 16.7 14.7 27.8 17.3 20.2 18.7 14.4 6.8 18.0 22.8 15.7 29.8 7.2 36.0 38.3 12.3 14.1 35.0 27.4 17.7 16.1 19.4 17.0 16.4 42.1 14.1 22.5 47.5 4.8 4.1 31.6 10.1 15.0 25.6 4.8 24.7 6.7 22.2 33.1 14.5 25.6 4.7 23.1 15.0 7.2 23.5 9.0 28.9 21.3 20.9 18.8 12.9 8.5 41.0 24.8 29.6 17.1 39.5 7.7 5.4 7.4 17.6 8.8 5.4 9.8 12.0 11.8 8.9 8.5 14.5 6.0 5.8 28.4 7.7 3.3 20.7 11.3 4.2 10.7 11.8 8.1 13.0 10.2 10.0 16.3 9.8 11.8 9.1 14.2 12.0 88.0 41.7 55.6 125.7 29.3 24.1 20.2 17.8 33.6 41.7 20.6 11.6 119.8 40.0 28.4 92.0 225.2 1.4 29.1 40.7 3.9 11.9 7.2 32.4 39.1 50.2 32.3 54.5 69.2 12.6 4.2 36.3 42.8 46.2 25.2 40.3 65.0 34.2 13.0 18.5 47.5 35.8 16.2 41.7 32.8 9.3 29.2 34.8 23.2 202.4 16.5 21.4 16.5 74.4 84.0 13.1 31.4 28.6 53.9 21.9 29.8 50.3 36.0 147.2 26.3 41.9 31.2 3.8 11.3 45.3 31.7 32.8 26.4 13.3 29.0 15.8 AKT1 "AKT, PKB, PRKBA, RAC, RAC-alpha" ENSG00000142208 "AKT serine/threonine kinase 1" P31749 14 104769349-104795751 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins, Transporters" "Apoptosis, Carbohydrate metabolism, Glucose metabolism, Glycogen biosynthesis, Glycogen metabolism, Neurogenesis, Sugar transport, Translation regulation, Transport" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "eosinophil: 61.5" "Lineage enriched" "Detected in all" 5 "granulocytes: 61.5" "Cell line enhanced" "Detected in all" "MCF7: 558.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002891, CAB003765" Supported Supported Nucleoplasm,Microtubules NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 30: Mammary glandular cells - Lactation" Nucleoplasm Microtubules "CAB003765: AB_562035, HPA002891: AB_1078123" "unprognostic (3.30e-2)" "unprognostic (4.27e-2)" "unprognostic (1.98e-1)" "unprognostic (1.84e-1)" "unprognostic (3.70e-1)" "unprognostic (9.17e-3)" "unprognostic (1.55e-3)" "unprognostic (1.21e-1)" "unprognostic (1.47e-1)" "prognostic favorable (4.83e-4)" "unprognostic (3.58e-2)" "unprognostic (1.90e-2)" "prognostic favorable (2.12e-4)" "unprognostic (7.14e-2)" "unprognostic (1.28e-1)" "unprognostic (1.06e-1)" "unprognostic (2.41e-1)" 71.5 102.7 45.9 57.7 45.5 51.2 61.2 43.7 53.2 52.0 50.4 85.0 50.8 59.5 23.2 70.7 53.7 50.0 105.9 45.2 44.3 54.3 97.3 69.2 51.9 50.5 45.7 43.7 94.3 53.0 35.9 55.4 45.0 67.2 39.6 25.1 67.7 73.0 58.1 45.0 53.3 63.4 47.4 63.7 77.8 23.9 48.0 52.4 52.3 64.9 40.3 72.6 48.4 43.3 77.3 150.5 124.6 186.9 95.2 97.7 136.9 142.3 171.5 204.6 163.6 96.8 92.8 91.2 105.5 196.6 102.8 99.4 89.5 131.9 90.1 214.3 36.2 70.6 90.4 103.2 104.6 117.5 178.0 140.0 109.1 102.9 68.1 98.2 154.4 87.5 62.1 102.2 134.1 558.3 145.3 146.8 32.6 153.5 107.2 137.5 111.9 60.5 94.8 189.5 141.2 117.2 117.3 152.2 88.9 56.8 195.7 170.2 123.5 133.2 63.2 192.3 145.1 105.4 52.6 80.7 113.7 96.7 162.0 6.4 9.9 61.5 10.0 10.3 7.2 5.5 8.7 11.4 7.0 7.2 4.6 10.1 22.6 11.0 12.4 10.0 9.0 6.3 45.9 45.5 43.7 53.2 45.2 44.3 50.5 45.7 45.0 47.4 48.0 43.3 45.8 16.0 27.4 16.6 13.7 12.4 20.0 17.3 15.9 26.3 58.0 39.9 16.1 32.9 17.7 22.0 12.5 19.4 54.2 40.9 13.7 23.6 1.9 17.9 28.1 27.5 30.0 11.3 8.2 35.2 31.8 24.0 26.0 24.8 2.5 40.4 23.2 42.9 23.2 42.1 13.0 37.3 22.4 23.3 21.4 3.3 28.6 28.0 10.6 6.5 23.1 51.2 24.7 8.0 9.6 53.3 22.1 30.9 10.3 38.8 23.5 17.9 14.2 26.6 26.3 24.9 29.1 1.8 5.3 16.2 13.9 23.4 23.3 34.0 33.7 33.4 AKT2 PKBβ ENSG00000105221 "AKT serine/threonine kinase 2" P31751 19 40230317-40285536 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Carbohydrate metabolism, Glucose metabolism, Glycogen biosynthesis, Glycogen metabolism, Sugar transport, Translation regulation, Transport" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Diabetes mellitus, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004204, HPA064521" Uncertain Supported Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 17: Basophils - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Vesicles, Cytosol" "CAB004204: AB_626659, HPA064521: AB_2685278" "unprognostic (6.13e-2)" "unprognostic (2.21e-1)" "unprognostic (1.56e-1)" "prognostic unfavorable (1.05e-6)" "unprognostic (2.85e-1)" "unprognostic (6.40e-3)" "unprognostic (9.59e-2)" "unprognostic (1.22e-2)" "unprognostic (2.98e-2)" "unprognostic (2.49e-2)" "unprognostic (3.02e-1)" "prognostic unfavorable (4.74e-4)" "unprognostic (1.30e-2)" "unprognostic (1.89e-1)" "unprognostic (3.28e-1)" "unprognostic (6.16e-2)" "unprognostic (2.00e-1)" 62.8 40.0 31.7 37.3 31.3 48.4 38.6 58.3 40.0 49.8 55.1 42.3 24.5 43.5 49.4 42.5 46.1 25.1 40.8 31.5 24.5 52.2 59.2 30.7 38.1 32.0 26.0 53.9 41.9 58.5 47.8 27.6 26.3 41.2 23.3 41.2 32.5 45.0 101.3 39.4 35.6 34.2 22.1 38.1 33.1 29.7 28.0 53.4 100.1 118.7 37.0 39.8 41.5 35.2 66.2 160.1 63.1 61.5 72.0 88.9 32.5 41.7 63.5 87.6 77.9 71.8 60.8 67.4 36.8 96.3 37.2 28.2 66.8 90.0 56.1 62.5 74.3 43.4 116.5 44.7 45.8 50.7 50.5 82.7 53.6 58.6 56.4 71.9 19.0 73.0 57.3 67.5 49.8 54.6 81.1 24.7 31.7 73.7 41.5 54.2 32.1 48.5 68.3 105.7 82.7 49.8 43.3 75.0 35.0 62.5 59.8 64.9 18.8 52.7 51.5 47.3 67.6 61.5 59.0 56.4 52.6 59.7 44.3 5.7 2.6 2.1 2.2 1.2 2.2 1.9 1.8 1.5 1.7 2.9 1.7 2.6 4.0 1.7 1.6 4.9 1.6 1.7 31.7 31.3 58.3 40.0 31.5 24.5 32.0 26.0 26.3 22.1 28.0 35.2 18.1 16.0 15.9 51.2 33.0 23.8 23.9 20.9 26.2 67.6 25.3 23.9 31.2 30.0 18.1 60.7 41.7 31.3 26.0 23.7 21.5 19.7 5.5 26.2 26.7 17.4 19.2 19.1 30.4 30.4 25.2 27.9 20.9 25.8 14.0 44.2 13.9 87.5 22.3 60.6 25.3 20.1 22.4 23.2 17.5 10.5 42.9 20.0 23.2 23.4 21.7 46.2 50.4 41.7 40.6 24.8 16.9 26.7 30.4 29.7 21.8 24.8 24.9 97.4 19.7 29.3 25.0 14.8 15.6 31.1 27.4 38.7 23.1 56.9 23.3 29.4 ALK CD246 ENSG00000171094 "ALK receptor tyrosine kinase" Q9UM73 2 29192774-29921586 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 8 "brain: 10.9" "Group enriched" "Detected in some" 5 "Inhibitory neurons: 274.2;Oligodendrocyte precursor cells: 433.8" "Group enriched" "Detected in some" 5 "glioma: 1.0;melanoma: 1.5;ovarian cancer: 0.7;thyroid cancer: 1.3" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 6 "SH-SY5Y: 31.7" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA010694 Approved Supported "Plasma membrane" NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane" "HPA010694: AB_1078133" "unprognostic (4.96e-2)" "unprognostic (1.11e-2)" "unprognostic (1.45e-1)" "unprognostic (4.56e-7)" "unprognostic (7.17e-2)" "unprognostic (1.71e-1)" "unprognostic (9.07e-3)" "unprognostic (6.29e-3)" "unprognostic (1.18e-1)" "unprognostic (1.01e-1)" "unprognostic (2.67e-4)" "unprognostic (3.70e-2)" "unprognostic (2.06e-2)" "unprognostic (7.15e-2)" "unprognostic (1.98e-1)" "unprognostic (1.38e-1)" "unprognostic (3.61e-2)" 0.3 0.6 2.2 0.2 2.4 0.0 0.1 0.7 2.8 0.1 0.8 0.6 0.1 0.0 0.0 0.0 0.0 0.2 0.0 1.5 3.9 0.0 0.0 0.1 0.0 4.4 6.8 0.0 0.0 0.0 1.3 0.0 10.9 0.0 0.2 0.7 0.1 0.1 0.0 0.1 0.3 0.1 2.9 0.0 0.1 1.2 2.7 0.0 0.3 0.0 0.0 0.0 0.0 2.1 0.1 0.0 0.5 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.6 0.0 4.3 0.0 0.0 0.1 0.4 31.7 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 3.7 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 2.4 0.7 2.8 1.5 3.9 4.4 6.8 10.9 2.9 2.7 2.1 0.0 0.0 0.0 66.6 0.0 0.0 0.0 0.0 0.0 1.9 0.2 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 42.1 0.5 0.1 0.2 0.0 0.0 12.5 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 3.4 0.0 274.2 0.0 0.0 0.0 0.0 41.2 0.0 0.5 0.0 7.5 0.0 0.6 0.0 433.8 21.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.1 0.1 0.8 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 AMER1 "FAM123B, FLJ39827, RP11-403E24.2, WTX" ENSG00000184675 "APC membrane recruitment protein 1" Q5JTC6 X 64185117-64205708 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Wnt signaling pathway" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "tongue: 15.3" "Cell type enhanced" "Detected in many" "Sertoli cells: 6.6;Theca cells: 6.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "NTERA-2: 15.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA065214, HPA065265" Approved Supported "Nuclear bodies,Vesicles,Plasma membrane" NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 5: NTERA-2 - Transcription" "Cluster 10: Non-specific - Unknown function" "Nuclear bodies" "Vesicles, Plasma membrane" "HPA065214: AB_2685435, HPA065265: AB_2685450" "unprognostic (1.56e-2)" "unprognostic (8.85e-2)" "unprognostic (6.86e-2)" "unprognostic (2.74e-1)" "unprognostic (2.12e-2)" "unprognostic (1.86e-1)" "unprognostic (3.57e-2)" "unprognostic (1.48e-1)" "unprognostic (8.02e-2)" "unprognostic (1.75e-1)" "unprognostic (6.31e-2)" "unprognostic (3.43e-1)" "unprognostic (4.69e-4)" "unprognostic (1.26e-1)" "unprognostic (1.13e-1)" "unprognostic (6.19e-2)" "unprognostic (2.89e-1)" 1.1 1.4 1.6 1.3 1.5 1.2 1.3 1.8 1.6 1.9 0.1 1.5 1.5 1.9 4.0 2.8 2.2 1.0 1.3 1.0 1.6 1.8 2.1 1.2 1.2 1.5 1.4 6.3 2.0 1.6 0.7 0.8 1.5 1.7 1.3 1.3 2.2 2.2 4.1 2.2 1.3 2.8 0.7 1.3 1.6 0.4 1.9 1.6 1.4 15.3 1.6 1.3 1.3 1.0 3.1 2.2 5.8 4.6 2.2 2.1 4.7 1.4 1.2 2.1 1.3 7.3 1.1 5.9 1.8 3.0 1.6 4.3 12.5 4.1 2.0 2.5 2.5 3.7 4.9 4.9 1.6 7.7 0.9 3.0 5.3 1.6 3.2 1.7 1.2 4.6 5.6 5.9 1.1 3.7 5.2 4.0 15.6 4.0 4.4 11.7 9.4 4.3 0.9 1.0 2.6 3.9 3.7 5.0 1.9 4.8 1.6 2.1 0.8 2.5 5.8 6.7 1.9 3.0 2.2 4.4 1.2 8.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.6 1.5 1.8 1.6 1.0 1.6 1.5 1.4 1.5 0.7 1.9 1.0 0.9 0.0 0.0 1.0 1.5 2.2 0.6 0.9 2.8 5.0 1.7 1.5 2.6 4.3 0.3 0.0 2.1 1.1 3.4 1.1 0.0 1.2 0.1 3.3 2.6 1.5 1.2 0.8 0.8 1.6 0.8 1.8 3.6 2.0 0.0 3.9 1.4 2.6 0.4 0.0 1.3 1.0 0.0 1.0 0.3 0.2 2.5 0.5 1.8 1.0 1.2 0.2 0.0 1.0 0.6 0.7 0.5 4.1 2.4 1.2 0.8 0.8 0.0 1.0 6.6 2.3 4.4 0.0 0.2 3.6 2.6 0.7 0.9 6.4 1.6 0.7 APC "DP2, DP2.5, DP3, PPP1R46" ENSG00000134982 "APC regulator of WNT signaling pathway" P25054 5 112707498-112846239 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Wnt signaling pathway" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 52.8" "Cell type enhanced" "Detected in many" "Astrocytes: 536.4;Bipolar cells: 196.9;Excitatory neurons: 165.8;Inhibitory neurons: 236.4;Oligodendrocyte precursor cells: 196.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA013349, HPA013362" Supported Approved "Nucleoplasm,Golgi apparatus,Plasma membrane" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 65: Brain - Ion transport" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 64: Astrocytes - Nervous system maintenance" "Plasma membrane" "Nucleoplasm, Golgi apparatus" "HPA013349: AB_1844913, HPA013362: " "unprognostic (4.80e-2)" "unprognostic (1.19e-1)" "unprognostic (3.72e-2)" "unprognostic (1.14e-1)" "unprognostic (1.10e-1)" "unprognostic (7.09e-3)" "unprognostic (1.62e-1)" "unprognostic (8.10e-3)" "unprognostic (2.35e-1)" "unprognostic (4.85e-3)" "unprognostic (1.27e-1)" "unprognostic (4.18e-2)" "unprognostic (1.02e-2)" "unprognostic (1.07e-1)" "unprognostic (3.35e-1)" "unprognostic (2.23e-2)" "unprognostic (1.96e-1)" 6.9 4.6 28.4 6.2 26.0 9.1 5.7 23.1 31.0 5.7 0.1 6.7 6.2 5.6 3.3 7.7 4.3 4.9 7.2 52.8 27.4 6.2 5.7 6.2 5.6 32.1 30.7 6.6 4.1 8.5 3.9 5.1 39.0 5.2 6.2 20.0 3.8 4.1 8.5 5.7 8.5 7.5 16.0 6.1 5.0 5.1 37.9 8.5 5.9 11.8 5.9 5.4 3.6 20.9 11.3 10.1 16.8 12.2 13.4 11.3 6.7 17.9 8.5 9.7 11.5 8.2 8.9 22.0 17.0 23.1 15.5 9.0 17.4 14.6 15.9 13.2 12.2 16.8 14.9 6.2 6.6 8.4 8.6 9.3 9.8 16.6 10.8 6.8 13.6 10.2 20.9 7.2 14.3 7.8 9.6 4.2 6.0 6.1 3.6 8.1 20.8 10.7 8.9 14.1 17.0 10.1 16.9 6.5 7.1 6.8 9.1 6.7 22.8 19.6 9.5 19.5 13.6 5.6 9.5 8.2 10.8 15.3 11.2 11.8 2.5 4.9 2.9 1.3 2.4 2.8 1.5 1.9 2.1 3.1 2.4 2.4 11.4 2.9 2.4 2.7 1.5 1.0 28.4 26.0 23.1 31.0 52.8 27.4 32.1 30.7 39.0 16.0 37.9 20.9 40.6 51.3 23.6 536.4 21.9 11.2 8.9 10.1 19.9 196.9 13.1 14.9 56.6 18.6 20.1 0.0 66.7 5.4 28.9 28.6 0.0 18.7 10.5 20.1 27.6 31.2 27.5 17.4 165.8 19.5 6.5 25.9 19.4 29.7 19.0 28.7 26.7 13.9 16.3 79.1 236.4 17.2 2.0 18.9 12.4 5.5 17.7 27.8 17.8 85.3 30.7 23.4 23.7 196.6 150.8 20.3 34.7 19.5 22.9 10.4 37.2 5.1 18.0 41.5 39.5 44.1 34.0 19.2 30.4 26.5 11.6 2.9 22.4 27.1 16.0 8.9 APC2 APCL ENSG00000115266 "APC regulator of WNT signaling pathway 2" O95996 19 1446302-1473244 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Wnt signaling pathway" "Disease variant, Lissencephaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 10 "brain: 64.5" "Cell type enhanced" "Detected in some" "Astrocytes: 142.4;Bipolar cells: 50.4;Excitatory neurons: 26.8;Horizontal cells: 45.4;Inhibitory neurons: 27.5;Muller glia cells: 29.4;Oligodendrocyte precursor cells: 28.1" "Cancer enriched" "Detected in some" 27 "glioma: 17.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 7.8;SCLC-21H: 9.3;SH-SY5Y: 31.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA078002 Supported "Cytokinetic bridge,Midbody,Cytosol" Yes No "Cluster 70: Brain - Nervous system development" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 64: Astrocytes - Nervous system maintenance" "Cytokinetic bridge, Midbody" Cytosol "HPA078002: AB_2686874" "unprognostic (1.78e-3)" "unprognostic (1.65e-1)" "unprognostic (2.88e-5)" "unprognostic (3.64e-2)" "unprognostic (3.59e-1)" "unprognostic (1.52e-2)" "unprognostic (1.00e-1)" "unprognostic (1.32e-1)" "unprognostic (1.86e-1)" "unprognostic (1.38e-2)" "unprognostic (1.30e-2)" "unprognostic (3.45e-2)" "unprognostic (9.49e-3)" "unprognostic (7.39e-2)" "unprognostic (3.70e-2)" "unprognostic (4.99e-2)" "unprognostic (1.98e-3)" 0.1 2.4 41.5 0.0 27.3 0.0 0.0 41.4 42.4 0.1 0.0 0.9 0.5 0.0 0.0 0.0 0.0 0.1 0.3 37.1 20.8 0.0 0.0 0.0 0.0 64.5 42.3 0.0 0.3 0.0 6.2 0.0 54.9 0.1 0.0 2.7 0.2 0.0 0.2 0.1 0.4 0.1 38.3 0.0 0.3 1.0 54.6 0.0 0.1 0.0 0.0 0.1 0.2 49.0 0.2 0.6 7.8 0.4 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.9 0.0 0.1 0.1 0.0 0.5 0.2 0.1 0.0 0.0 1.0 0.1 0.0 0.4 0.0 0.2 0.1 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.3 0.5 0.2 0.1 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.6 0.0 0.0 9.3 31.7 1.1 0.0 0.5 0.1 0.1 0.0 0.0 0.4 0.6 0.1 0.1 1.7 0.5 0.2 0.7 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 41.5 27.3 41.4 42.4 37.1 20.8 64.5 42.3 54.9 38.3 54.6 49.0 0.3 0.0 0.0 142.4 0.3 0.0 0.2 0.2 1.2 50.4 0.4 0.4 3.4 0.0 0.0 0.0 0.0 0.2 0.1 0.2 0.0 0.0 0.1 0.5 0.5 0.5 0.0 0.0 26.8 0.0 0.1 0.3 0.0 0.6 0.0 0.2 0.0 0.0 0.1 45.4 27.5 0.0 0.0 0.0 0.0 0.7 0.3 0.1 0.0 3.7 0.0 29.4 2.1 28.1 17.8 0.0 0.0 0.7 0.0 0.1 0.2 0.2 0.0 11.1 0.0 0.6 0.4 0.4 0.7 2.4 0.0 0.0 0.3 0.2 0.1 0.2 AR "AIS, DHTR, HUMARA, NR3C4, SBMA, SMAX1" ENSG00000169083 "Androgen receptor" P10275 X 67544021-67730619 "Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding, Receptor" "Cancer-related genes, Disease variant, FDA approved drug targets, Neurodegeneration, Pseudohermaphroditism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 38.2" "Cell type enhanced" "Detected in many" "Breast glandular cells: 93.7;Granulosa cells: 104.8;Hepatocytes: 269.2;Leydig cells: 77.9;Peritubular cells: 86.5;Skeletal myocytes: 75.0" "Cancer enhanced" "Detected in many" "breast cancer: 15.6;prostate cancer: 16.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 13.3;BJ hTERT+: 10.3;HAP1: 14.9;LHCN-M2: 16.1;RH-30: 23.6;T-47d: 10.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB000001, HPA004733, CAB065764" Enhanced Supported Cytosol NA NA "Cluster 85: Liver - Metabolism" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 35: Glandular cells - Unknown function" Cytosol "CAB000001: AB_2060174, CAB065764: AB_10620739, HPA004733: " "unprognostic (1.34e-1)" "unprognostic (8.10e-3)" "unprognostic (2.49e-2)" "unprognostic (5.95e-2)" "unprognostic (1.04e-2)" "unprognostic (3.35e-2)" "prognostic favorable (8.77e-4)" "unprognostic (4.99e-2)" "unprognostic (1.72e-1)" "unprognostic (7.79e-2)" "unprognostic (2.30e-1)" "unprognostic (2.29e-1)" "prognostic favorable (1.03e-8)" "unprognostic (8.23e-3)" "unprognostic (8.90e-2)" "unprognostic (4.23e-2)" "unprognostic (7.97e-2)" 6.7 1.0 1.1 0.5 1.3 0.0 8.7 1.7 1.1 23.6 0.2 2.0 0.2 18.6 16.1 1.2 20.7 2.0 5.8 1.0 3.5 3.6 38.2 1.5 0.3 3.5 2.6 14.6 0.8 0.1 1.9 0.1 2.7 16.5 0.6 0.2 1.4 18.2 13.9 5.2 0.9 9.5 2.1 1.3 1.5 3.9 4.8 2.7 2.1 6.1 0.5 3.5 12.9 2.0 0.0 4.8 13.3 0.0 0.0 0.0 0.0 7.3 10.3 0.3 0.1 0.1 0.0 0.0 0.0 1.0 0.0 0.0 14.9 0.0 0.0 0.0 2.4 0.0 1.5 0.0 0.8 0.0 0.0 5.5 0.0 1.8 0.0 0.0 3.9 0.1 4.6 2.2 16.1 1.5 0.0 0.0 5.4 0.0 0.0 0.0 23.6 0.1 0.4 0.0 0.0 0.0 0.0 0.3 0.0 3.6 10.9 7.6 0.3 0.3 2.2 0.0 3.5 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 1.3 1.7 1.1 1.0 3.5 3.5 2.6 2.7 2.1 4.8 2.0 3.1 0.0 5.0 28.4 0.4 9.7 17.8 0.2 15.9 0.7 93.7 33.7 37.4 14.3 10.7 3.7 0.0 3.5 14.0 0.0 1.9 11.3 1.1 2.9 49.1 10.5 0.0 5.3 7.7 0.0 0.2 39.4 0.0 5.8 1.3 104.8 36.0 269.2 0.8 0.0 17.8 0.3 0.0 2.2 4.2 4.4 77.9 3.3 10.6 1.0 1.7 0.2 0.0 26.7 0.2 0.6 0.0 86.5 0.0 36.5 0.6 27.7 3.6 0.3 65.7 75.0 20.8 0.8 3.3 12.7 16.1 1.0 1.7 37.8 0.2 22.0 ARAF ARAF1 ENSG00000078061 "A-Raf proto-oncogene, serine/threonine kinase" P10398 X 47561205-47571908 "Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA066326 Approved NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 27: Mucus-secreting cells - Mucin production" "HPA066326: AB_2685659" "unprognostic (1.21e-1)" "unprognostic (5.69e-3)" "unprognostic (2.47e-2)" "unprognostic (2.10e-2)" "unprognostic (7.63e-2)" "unprognostic (9.35e-2)" "unprognostic (1.79e-2)" "unprognostic (1.07e-1)" "unprognostic (3.76e-2)" "unprognostic (1.61e-1)" "unprognostic (6.75e-2)" "unprognostic (8.65e-2)" "prognostic favorable (1.45e-6)" "unprognostic (1.97e-1)" "unprognostic (2.01e-1)" "unprognostic (6.37e-2)" "unprognostic (4.71e-2)" 37.7 41.7 17.8 36.9 20.8 102.3 36.2 19.2 21.1 34.8 22.6 40.9 37.8 36.6 21.2 32.2 35.0 32.5 50.8 17.1 18.0 44.6 55.7 39.4 40.4 22.8 20.5 39.5 59.1 51.8 27.7 31.3 20.1 40.9 33.3 15.4 45.1 34.6 136.3 36.0 39.7 31.3 18.8 46.1 46.7 12.0 21.0 38.0 39.4 85.6 31.5 36.1 30.8 20.4 49.1 69.5 29.2 46.9 43.5 34.2 39.0 40.3 42.3 58.6 54.1 57.2 58.6 29.0 32.4 54.6 49.2 67.3 51.8 56.3 34.3 53.5 61.9 29.4 74.4 30.6 61.4 58.3 85.1 45.0 56.0 56.2 49.6 39.2 45.9 36.0 55.2 55.7 40.5 83.3 42.6 64.0 41.8 41.2 77.8 39.2 38.0 65.5 34.4 46.7 32.8 25.0 43.7 39.7 24.5 47.0 74.9 43.3 44.2 38.0 42.5 76.2 41.4 71.1 49.2 22.5 50.8 65.3 31.1 48.3 47.8 61.3 44.1 57.8 40.3 32.6 38.4 40.9 55.2 37.3 33.5 40.5 37.8 38.7 67.9 40.4 41.6 50.8 17.8 20.8 19.2 21.1 17.1 18.0 22.8 20.5 20.1 18.8 21.0 20.4 13.3 16.0 29.2 7.5 25.8 15.7 25.0 29.0 18.2 5.3 15.0 9.8 25.1 34.3 22.0 18.4 10.4 33.0 26.3 43.8 23.5 29.3 1.3 11.4 10.8 17.5 31.8 22.3 5.0 34.3 30.4 16.9 39.3 15.6 16.5 13.6 24.3 42.6 28.0 13.5 5.5 35.9 40.7 26.4 21.6 4.3 17.4 25.8 33.8 4.7 43.7 18.4 32.0 8.5 8.9 26.2 41.5 17.7 27.9 20.3 44.6 27.1 11.5 9.0 19.7 15.9 18.0 8.2 10.5 17.7 16.2 44.6 26.5 12.5 32.3 24.6 AREG "AREGB, SDGF" ENSG00000109321 Amphiregulin P15514 4 74445136-74455005 "Cancer-related genes, Human disease related genes, Predicted membrane proteins" "Cytokine, Growth factor" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 129.9;placenta: 328.8;urinary bladder: 145.6" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 1119.1;Basal prostatic cells: 1254.3;Macrophages: 1271.1;Paneth cells: 909.8;Urothelial cells: 2102.9" "Cancer enhanced" "Detected in all" "colorectal cancer: 67.1" "Not detected" "Not detected" "Group enriched" "Detected in some" 11 "basophil: 11.0;eosinophil: 11.8;NK-cell: 3.8" "Group enriched" "Detected in many" 10 "granulocytes: 11.8;NK-cells: 3.8" "Cell line enhanced" "Detected in many" "CACO-2: 379.0;HBEC3-KT: 648.1;hTCEpi: 644.0;hTERT-HME1: 1365.7;MCF7: 416.8" "Region enriched" "Detected in single" 4 "olfactory bulb: 1.2" "Low region specificity" "Detected in many" "HPA008720, CAB023519" Approved Approved Mitochondria NA NA 1520000 "Cluster 2: Granulocytes - Unknown function" "Cluster 28: Placenta - Pregnancy" "Cluster 30: Epithelial cell lines - Translation" "Cluster 41: Macrophages - Immune response" Mitochondria "CAB023519: AB_2060673, HPA008720: AB_1844978" "unprognostic (1.44e-2)" "unprognostic (1.84e-3)" "unprognostic (3.36e-2)" "unprognostic (2.26e-1)" "unprognostic (3.54e-3)" "prognostic unfavorable (2.61e-5)" "unprognostic (1.02e-2)" "prognostic unfavorable (1.05e-5)" "unprognostic (2.90e-1)" "unprognostic (8.06e-2)" "prognostic unfavorable (8.32e-5)" "unprognostic (2.56e-2)" "unprognostic (2.49e-3)" "unprognostic (2.40e-2)" "unprognostic (1.69e-1)" "unprognostic (1.23e-1)" "unprognostic (6.83e-3)" 48.1 4.6 0.1 36.7 0.1 129.9 61.6 0.1 0.8 19.2 1.8 18.7 3.3 3.7 0.2 43.4 13.2 74.1 20.5 0.3 0.1 2.5 4.0 36.1 1.9 0.3 0.2 12.4 4.5 1.5 9.5 328.8 0.8 6.5 18.9 0.1 11.7 0.7 18.4 15.3 10.2 6.5 0.2 10.0 20.2 9.3 0.4 7.1 5.4 0.8 3.0 145.6 13.8 0.4 15.9 107.3 0.0 0.0 0.9 1.4 0.0 3.2 5.0 0.7 2.9 379.0 59.8 0.0 8.0 0.0 0.0 17.4 0.1 648.1 6.5 0.1 0.0 0.4 2.8 18.0 191.9 2.3 0.4 5.9 644.0 37.8 1365.7 0.9 0.2 0.4 1.6 0.7 14.4 416.8 0.2 0.0 0.0 78.6 42.8 0.0 0.1 0.1 36.4 2.9 0.5 0.2 22.2 1.2 0.0 0.4 11.6 0.1 1.0 0.0 15.3 5.3 0.1 0.9 0.0 0.1 0.0 0.0 1.7 11.0 0.0 11.8 0.0 0.0 0.0 0.2 0.4 0.0 0.8 0.3 0.2 0.0 0.1 3.8 0.0 0.1 0.0 0.1 0.1 0.1 0.1 0.8 0.3 0.1 0.3 0.2 0.8 0.2 0.4 0.4 670.0 198.7 301.9 0.0 190.7 1119.1 1254.3 73.0 303.9 0.0 801.5 460.2 49.0 62.9 183.9 51.5 0.0 1.8 836.1 878.0 0.0 61.8 70.4 167.7 12.3 32.2 41.6 18.5 0.0 10.2 1.5 80.8 254.9 193.1 680.5 0.9 10.8 4.2 32.2 0.0 0.5 393.5 8.2 250.4 196.4 12.1 0.3 1271.1 33.8 0.0 1.7 0.8 20.6 0.0 0.0 497.1 909.8 1.2 352.1 115.3 55.7 0.7 53.3 0.2 19.7 10.3 20.2 68.3 51.1 194.5 342.4 1.1 473.6 1.2 308.9 2102.9 ARID1A "B120, BAF250, BAF250a, C10rf4, C1orf4, P270, SMARCF1" ENSG00000117713 "AT-rich interaction domain 1A" O14497 1 26693236-26782104 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Neurogenesis, Transcription, Transcription regulation" "Chromatin regulator, DNA-binding" "Cancer-related genes, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005456, CAB016334" Supported Enhanced Nucleoplasm NA Yes "Cluster 33: Neutrophils - Chromatin organization" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Nucleoplasm "CAB016334: AB_673396, HPA005456: AB_1078205" "unprognostic (2.83e-1)" "unprognostic (1.81e-1)" "unprognostic (7.48e-2)" "unprognostic (1.41e-1)" "unprognostic (2.44e-1)" "unprognostic (1.89e-2)" "prognostic unfavorable (4.18e-4)" "unprognostic (3.02e-1)" "unprognostic (3.66e-2)" "unprognostic (1.34e-1)" "unprognostic (9.69e-2)" "unprognostic (7.76e-2)" "unprognostic (1.01e-2)" "unprognostic (1.62e-2)" "unprognostic (6.05e-2)" "unprognostic (2.66e-1)" "unprognostic (6.54e-2)" 16.4 16.3 10.1 22.7 9.4 37.0 16.4 12.9 24.3 16.2 0.0 18.0 15.4 20.4 15.8 22.2 18.3 14.0 17.4 6.3 35.8 13.3 16.8 16.8 25.8 20.8 6.8 20.8 23.2 19.3 14.3 18.6 9.9 15.1 15.3 20.1 19.3 14.4 21.6 20.5 20.3 17.5 3.0 24.3 19.5 16.7 17.9 46.4 22.6 17.6 23.7 18.4 17.8 9.0 53.2 49.5 68.6 71.5 19.6 18.5 32.3 24.4 21.1 32.7 23.0 36.3 34.1 74.3 20.7 31.8 20.7 31.6 60.3 26.9 37.9 92.7 22.6 63.6 33.0 24.7 16.1 95.2 19.6 21.7 18.8 38.7 27.5 18.2 28.6 52.5 77.7 81.1 21.5 25.1 80.1 36.8 72.4 34.5 22.9 82.2 45.3 42.1 20.3 35.3 62.9 50.7 42.7 35.7 29.0 37.8 10.6 53.4 50.6 34.9 33.5 32.4 39.9 38.0 54.9 34.1 21.2 59.8 31.5 0.2 1.5 1.5 1.6 1.2 2.1 1.8 1.3 2.1 1.4 1.6 1.7 1.9 3.3 2.1 1.3 2.4 0.7 1.9 10.1 9.4 12.9 24.3 6.3 35.8 20.8 6.8 9.9 3.0 17.9 9.0 49.9 60.9 40.4 99.9 66.6 73.4 21.0 32.5 90.0 68.0 77.2 61.5 33.0 38.6 35.9 38.6 52.1 36.5 56.1 46.5 1.9 35.3 23.3 48.8 59.3 46.3 47.5 56.6 47.1 37.6 40.2 35.9 35.7 72.3 61.2 68.4 49.6 65.6 51.0 74.0 59.8 50.2 28.5 89.0 47.5 9.0 38.5 73.2 40.9 89.9 86.4 30.8 53.5 78.9 116.1 49.7 36.4 41.8 48.5 50.0 32.4 16.7 36.1 42.3 52.6 38.2 47.3 44.1 52.2 101.8 94.3 36.7 57.0 45.8 52.1 43.2 ARID2 "BAF200, DKFZp686G052, FLJ30619, KIAA1557" ENSG00000189079 "AT-rich interaction domain 2" Q68CP9 12 45729706-45908040 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Chromatin regulator, DNA-binding" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 525.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063044 Supported "Nucleoplasm,Plasma membrane" NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 23: Testis - Cell cycle regulation" "Cluster 43: THP-1 - Innate immune response" "Cluster 29: Early spermatids - Spermatogenesis" Nucleoplasm "Plasma membrane" "HPA063044: AB_2684929" "unprognostic (8.41e-2)" "unprognostic (1.03e-1)" "unprognostic (4.02e-2)" "unprognostic (3.94e-2)" "unprognostic (4.15e-2)" "prognostic favorable (5.75e-4)" "unprognostic (1.26e-2)" "unprognostic (9.71e-2)" "unprognostic (9.04e-2)" "unprognostic (5.57e-2)" "unprognostic (1.34e-1)" "unprognostic (2.47e-1)" "unprognostic (1.12e-2)" "unprognostic (9.21e-2)" "unprognostic (3.02e-1)" "unprognostic (2.00e-1)" "unprognostic (6.53e-2)" 6.4 5.2 4.6 6.7 7.8 12.6 7.5 13.8 6.9 8.5 10.2 6.8 5.0 6.9 6.5 8.4 6.4 5.4 6.0 5.0 7.3 6.3 5.4 7.8 7.5 7.8 6.4 8.3 7.2 11.7 5.0 7.2 7.6 7.4 6.0 13.2 6.7 6.2 5.9 10.0 6.6 6.1 6.0 6.9 6.2 26.1 6.2 18.7 8.8 7.7 8.9 6.8 8.0 9.8 10.3 14.5 25.3 11.1 10.5 7.3 13.7 7.0 9.9 9.6 8.9 20.7 10.4 19.8 12.7 9.8 7.0 12.1 20.6 11.8 13.6 8.8 9.8 26.1 15.9 10.1 7.2 20.7 11.5 6.0 8.8 12.1 19.1 13.4 10.0 29.1 22.4 19.9 8.6 13.4 29.9 14.7 15.1 0.0 7.7 22.9 18.0 19.0 9.1 16.9 13.6 17.4 11.4 13.0 11.1 14.5 20.0 40.8 11.8 10.3 12.3 7.0 9.2 13.2 11.8 53.6 7.9 53.2 7.4 9.4 1.1 2.7 2.4 1.3 2.5 1.0 2.1 2.5 1.5 1.1 2.0 1.9 1.4 2.1 3.4 3.3 2.0 0.9 4.6 7.8 13.8 6.9 5.0 7.3 7.8 6.4 7.6 6.0 6.2 9.8 23.3 28.9 28.4 110.4 30.8 33.8 14.4 16.3 36.5 51.6 21.7 15.4 15.6 14.3 17.3 29.5 68.8 15.5 49.0 21.3 7.9 13.2 525.4 23.2 23.8 21.1 21.0 35.1 56.7 10.0 10.5 22.0 24.5 27.7 22.1 29.3 19.2 17.3 11.2 32.0 60.3 19.0 22.4 29.8 36.7 149.3 24.8 25.6 14.2 128.4 22.4 19.9 45.3 144.3 157.9 18.8 24.6 22.6 33.8 23.7 19.1 7.4 15.4 66.2 26.3 27.0 27.2 80.2 17.0 39.3 41.3 23.4 34.8 16.4 17.9 21.0 ASXL1 KIAA0978 ENSG00000171456 "ASXL transcriptional regulator 1" Q8IXJ9 20 32358330-32439319 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "Chromatin regulator, Repressor" "Cancer-related genes, Craniosynostosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA064156 Approved Nucleoplasm,Nucleoli NA NA "Cluster 35: T-regs - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Nucleoli" "HPA064156: AB_2685200" "unprognostic (1.49e-1)" "unprognostic (5.97e-2)" "unprognostic (8.36e-2)" "prognostic unfavorable (2.86e-4)" "unprognostic (6.69e-2)" "prognostic favorable (9.16e-4)" "unprognostic (2.01e-3)" "unprognostic (2.89e-1)" "unprognostic (1.49e-1)" "unprognostic (1.38e-1)" "unprognostic (4.32e-2)" "unprognostic (3.21e-2)" "unprognostic (1.84e-3)" "unprognostic (5.47e-2)" "unprognostic (1.90e-1)" "unprognostic (4.82e-2)" "unprognostic (1.06e-1)" 31.6 24.6 13.4 18.1 14.4 36.9 30.5 15.0 14.4 30.6 20.2 31.6 12.2 26.8 15.6 17.2 28.6 13.7 21.8 14.1 15.6 28.7 32.8 36.0 24.0 15.8 14.2 32.3 32.9 13.1 19.2 17.3 13.8 24.8 13.2 19.7 21.0 13.3 30.1 23.2 27.8 18.4 13.8 35.0 24.7 37.2 15.1 27.4 32.0 16.4 25.0 26.4 24.2 17.1 59.2 33.6 52.7 28.2 23.6 28.6 45.6 35.4 33.0 64.1 48.6 99.8 35.2 54.4 24.5 47.3 62.2 39.5 45.3 37.8 53.2 70.6 24.1 88.9 53.6 55.7 21.6 38.5 36.1 32.4 25.1 46.1 35.6 33.3 37.4 45.3 45.2 29.1 31.9 18.4 51.7 30.3 12.9 27.7 38.9 30.8 62.1 24.8 27.1 28.4 23.7 38.2 68.9 23.5 31.7 27.9 32.7 27.0 39.9 69.1 59.4 32.3 43.2 33.9 38.6 39.3 34.0 100.2 27.8 0.1 0.6 1.0 2.6 0.5 2.5 4.8 3.6 3.9 0.8 3.3 3.5 4.0 0.5 1.5 0.6 2.7 9.0 1.5 13.4 14.4 15.0 14.4 14.1 15.6 15.8 14.2 13.8 13.8 15.1 17.1 92.3 51.3 35.5 54.9 63.3 40.0 51.8 8.6 50.7 21.4 52.9 48.6 19.8 15.7 17.9 27.6 52.1 18.0 55.2 18.8 25.4 13.5 97.8 59.4 80.1 65.6 7.2 40.8 61.4 12.6 16.5 49.8 30.5 86.2 18.3 57.7 41.0 34.7 21.3 18.5 80.3 14.1 16.2 21.2 42.2 84.9 25.4 33.5 78.2 75.9 16.7 11.6 20.6 78.4 125.9 15.6 13.7 14.7 94.6 49.6 29.9 31.7 20.8 30.7 6.6 96.7 62.7 31.0 16.1 34.6 30.5 5.9 67.2 36.4 17.5 40.5 ATF1 TREB36 ENSG00000123268 "Activating transcription factor 1" P18846 12 50763710-50821162 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB016222, HPA055069, HPA055406" Supported Enhanced Nucleoplasm NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 52: Non-specific - Ribosome" "Cluster 30: Epithelial cell lines - Translation" "Cluster 22: Epithelial cell types - Mixed function" Nucleoplasm "CAB016222: AB_2290030, HPA055069: AB_2682688, HPA055406: AB_2682807" "unprognostic (1.71e-1)" "unprognostic (1.50e-3)" "unprognostic (1.50e-1)" "unprognostic (9.05e-2)" "unprognostic (6.68e-2)" "unprognostic (1.58e-1)" "prognostic unfavorable (1.53e-5)" "unprognostic (3.65e-1)" "unprognostic (8.17e-3)" "unprognostic (5.94e-2)" "unprognostic (4.31e-3)" "unprognostic (5.52e-2)" "unprognostic (1.73e-1)" "unprognostic (2.74e-2)" "unprognostic (2.46e-1)" "unprognostic (2.27e-1)" "unprognostic (8.75e-2)" 13.8 21.2 4.9 15.8 5.1 14.8 16.8 14.2 7.1 16.7 8.2 18.0 16.0 18.2 13.7 17.0 17.8 16.5 14.6 4.8 7.9 17.4 20.8 15.8 21.5 5.3 5.8 23.1 9.1 19.8 10.1 16.7 5.4 14.3 18.6 11.9 14.5 13.5 32.4 10.4 14.7 16.7 5.4 17.9 14.3 8.6 6.6 29.2 22.7 23.7 21.5 16.5 12.9 6.9 28.6 20.4 21.0 21.4 29.0 30.4 52.2 29.5 50.7 45.7 35.8 41.7 43.7 38.7 47.6 34.5 20.0 22.8 24.9 30.6 47.6 39.0 25.8 42.8 43.1 22.6 56.5 62.3 39.6 33.7 45.7 32.8 52.8 47.6 22.5 27.1 53.2 36.2 33.9 42.4 39.6 37.3 30.0 33.0 32.1 37.5 32.3 45.9 33.6 19.5 27.9 14.9 61.8 26.5 44.7 28.5 37.3 37.6 16.1 32.1 38.2 26.4 24.1 20.2 25.8 63.6 30.9 33.9 15.3 6.6 17.9 42.7 20.2 18.8 23.1 20.2 21.7 24.1 21.1 21.7 26.4 20.4 11.2 20.8 12.7 9.6 28.8 19.1 4.9 5.1 14.2 7.1 4.8 7.9 5.3 5.8 5.4 5.4 6.6 6.9 25.5 54.5 18.5 22.2 41.5 75.3 48.4 34.8 52.3 12.1 26.0 18.5 14.6 15.7 26.7 12.9 0.0 34.6 25.4 23.4 52.8 24.9 9.2 24.6 20.8 23.8 6.0 46.7 25.8 21.1 77.1 33.1 14.3 21.0 10.1 14.1 20.0 16.2 27.5 13.5 29.2 18.7 24.4 25.2 48.4 5.9 32.0 24.2 23.2 16.9 24.6 14.2 27.8 12.5 25.3 22.8 17.9 27.8 22.1 43.7 20.7 34.6 19.9 7.2 39.5 34.1 33.7 10.9 10.3 30.3 54.6 80.6 38.4 20.4 22.8 36.9 ATM "ATA, ATC, ATD, ATDC, TEL1, TELO1" ENSG00000149311 "ATM serine/threonine kinase" Q13315 11 108222832-108369102 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, DNA damage" "DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Neurodegeneration, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 210.6;NK-cells: 339.8;Oligodendrocytes: 217.6;Rod photoreceptor cells: 200.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 78.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000102, HPA067142" Supported Supported Nucleoplasm,Vesicles NA NA "Cluster 44: Non-specific - Transcription" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 63: NK-cells & T-cells - Immune response" Nucleoplasm Vesicles "CAB000102: , HPA067142: AB_2685789" "unprognostic (9.77e-2)" "unprognostic (1.47e-1)" "unprognostic (3.04e-1)" "unprognostic (2.36e-1)" "unprognostic (5.70e-2)" "unprognostic (2.86e-2)" "unprognostic (6.32e-3)" "unprognostic (1.05e-1)" "unprognostic (8.19e-2)" "unprognostic (1.63e-1)" "unprognostic (7.68e-2)" "unprognostic (6.16e-2)" "unprognostic (2.17e-3)" "unprognostic (3.10e-1)" "unprognostic (7.87e-2)" "unprognostic (1.21e-1)" "unprognostic (2.81e-1)" 6.2 7.4 8.2 17.5 15.0 16.2 8.5 17.0 12.3 8.7 16.1 6.7 5.2 10.0 9.9 4.0 7.5 8.2 7.0 7.3 11.3 5.8 7.8 7.6 33.7 15.8 13.1 15.8 14.8 9.3 12.1 8.0 17.0 6.3 7.0 20.6 11.4 6.1 4.4 7.5 12.6 6.9 10.3 22.2 8.6 5.2 12.7 18.2 8.8 6.0 25.9 7.1 6.9 28.8 4.3 6.8 14.8 7.6 20.2 29.1 3.1 10.9 13.5 6.4 11.3 7.1 10.3 18.3 14.0 10.2 9.6 7.7 11.6 10.8 9.0 12.3 5.7 15.2 8.7 10.2 10.5 16.4 17.0 18.3 6.3 10.0 21.2 15.2 14.1 16.5 12.4 9.9 14.3 3.4 10.6 18.5 9.8 8.6 7.4 9.7 9.7 24.9 8.1 7.5 9.0 10.5 11.1 4.7 20.6 13.2 9.3 10.1 23.7 15.8 8.4 7.3 9.0 6.2 7.0 78.3 7.0 19.0 18.8 21.3 5.5 4.0 16.5 5.7 11.1 11.6 11.7 12.5 2.6 13.0 21.1 20.4 9.9 9.7 13.3 6.2 6.1 5.3 8.2 15.0 17.0 12.3 7.3 11.3 15.8 13.1 17.0 10.3 12.7 28.8 23.7 38.5 20.8 62.7 146.4 12.6 17.5 21.1 28.5 111.0 19.6 14.2 39.9 12.8 19.5 22.0 210.6 16.9 140.2 4.2 5.9 9.9 19.2 14.4 52.1 25.9 20.4 39.1 70.2 12.3 13.2 39.0 12.8 20.9 13.3 45.9 32.9 23.3 29.1 60.6 82.8 14.9 26.4 96.4 34.0 5.1 39.4 69.2 26.6 178.9 63.2 27.3 339.8 85.5 217.6 7.6 7.6 27.8 96.5 9.1 8.9 11.1 16.0 200.1 26.3 41.4 29.2 31.5 37.4 15.8 12.4 4.2 147.7 52.3 11.5 10.2 ATR "FRP1, MEC1, SCKL, SCKL1" ENSG00000175054 "ATR serine/threonine kinase" Q13535 3 142449007-142578733 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "DNA damage, DNA repair" "DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Dwarfism, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 93.0;Inhibitory neurons: 94.4;Microglial cells: 73.1;Oligodendrocyte precursor cells: 65.4;Oligodendrocytes: 71.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054320 Supported "Nucleoplasm,Golgi apparatus" No No "Cluster 15: NK-cells - Transcription" "Cluster 17: Adrenal gland - Steroid metabolism" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "Golgi apparatus" "HPA054320: AB_2682448" "unprognostic (1.47e-1)" "unprognostic (8.90e-2)" "unprognostic (2.90e-1)" "unprognostic (4.23e-2)" "unprognostic (2.25e-2)" "unprognostic (6.42e-2)" "prognostic unfavorable (8.39e-5)" "unprognostic (3.44e-1)" "unprognostic (1.67e-1)" "unprognostic (3.02e-1)" "prognostic unfavorable (1.23e-5)" "unprognostic (1.94e-1)" "unprognostic (5.61e-2)" "unprognostic (1.06e-1)" "unprognostic (3.55e-1)" "unprognostic (1.69e-2)" "unprognostic (1.43e-1)" 3.0 8.6 0.7 4.1 1.1 1.2 3.2 0.9 1.4 3.8 3.7 2.7 1.7 3.3 2.3 3.1 3.3 3.4 2.3 1.2 1.9 3.7 3.6 2.9 4.8 1.5 1.2 2.7 3.8 5.2 3.7 3.1 1.4 3.0 2.9 2.9 3.5 2.5 2.9 2.7 3.1 3.2 1.0 4.2 2.8 5.2 1.2 4.9 5.0 1.4 4.6 4.1 2.7 1.2 28.6 13.2 7.1 7.0 9.6 13.6 8.8 14.8 8.4 10.1 9.7 6.4 6.8 19.9 14.6 10.1 14.6 16.1 10.9 12.8 15.0 7.5 7.9 11.9 8.2 4.1 4.2 20.5 5.3 9.8 4.8 9.5 10.3 5.8 11.6 8.7 8.2 7.5 9.6 7.5 13.9 2.6 7.3 15.6 9.6 11.8 12.5 13.5 6.3 11.1 5.2 5.1 28.6 8.3 8.0 7.8 12.0 5.4 14.6 10.5 4.9 12.3 15.2 10.8 7.4 18.5 13.8 6.5 8.5 0.0 0.3 0.0 0.5 0.4 1.0 0.1 0.3 0.5 0.7 0.3 0.4 0.4 0.0 1.3 0.2 0.2 0.4 0.2 0.7 1.1 0.9 1.4 1.2 1.9 1.5 1.2 1.4 1.0 1.2 1.2 11.5 6.4 10.6 39.2 22.4 4.0 7.2 8.8 14.2 14.1 9.2 6.5 7.6 5.7 10.1 3.7 37.5 7.7 14.9 3.5 0.0 5.9 16.4 18.8 18.6 10.2 7.7 14.5 93.0 4.9 3.6 8.3 14.8 10.3 1.3 16.3 7.9 7.3 6.4 8.4 94.4 4.8 14.2 9.4 4.0 8.7 6.5 12.8 10.6 73.1 12.0 6.0 9.2 65.4 71.9 6.4 1.8 7.2 23.1 8.1 1.9 6.5 25.4 23.6 0.0 14.6 9.8 50.1 18.5 14.7 4.5 5.1 15.1 13.8 7.6 6.1 ATRX "JMS, MRX52, RAD54, XH2, XNP" ENSG00000085224 "ATRX chromatin remodeler" P46100 X 77504880-77786233 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transcription factors" "DNA damage, DNA repair, Transcription, Transcription regulation" "Chromatin regulator, DNA-binding, Helicase, Hydrolase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001906, CAB009372, HPA064684, CAB068176" Supported Supported "Nuclear bodies" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 52: Non-specific - Transcription" "Nuclear bodies" "CAB009372: AB_2061023, CAB068176: AB_2665665, HPA001906: AB_1078249, HPA064684: AB_2685321" "unprognostic (1.77e-2)" "unprognostic (1.55e-1)" "unprognostic (6.65e-2)" "unprognostic (4.37e-2)" "unprognostic (1.67e-1)" "unprognostic (9.69e-2)" "unprognostic (8.11e-2)" "unprognostic (1.15e-2)" "unprognostic (6.04e-2)" "unprognostic (2.35e-2)" "unprognostic (1.09e-1)" "unprognostic (5.80e-2)" "unprognostic (5.14e-3)" "unprognostic (1.50e-1)" "unprognostic (6.19e-2)" "unprognostic (1.76e-2)" "unprognostic (2.24e-1)" 18.0 15.9 17.3 17.6 20.4 29.9 18.1 32.9 20.4 18.0 21.4 12.7 11.2 21.2 14.8 13.3 11.8 14.7 15.5 19.2 19.8 16.9 13.2 13.4 22.6 15.0 20.1 24.9 13.4 23.2 8.5 16.6 16.6 19.2 13.5 26.8 14.0 14.8 19.1 15.6 10.9 15.6 16.4 22.8 16.5 6.6 22.6 25.7 20.0 26.9 18.6 14.1 9.9 19.7 36.0 55.1 60.1 45.0 31.8 38.1 21.2 29.4 27.3 21.8 25.9 19.6 30.7 48.5 29.9 32.5 39.9 30.0 44.6 18.1 37.5 27.3 30.8 29.3 67.2 16.2 16.1 38.4 10.2 25.5 20.2 32.2 30.4 29.4 41.9 30.3 34.9 53.3 29.3 27.6 30.2 25.0 42.0 17.6 42.5 48.6 76.3 26.0 25.6 46.4 33.1 55.5 60.5 23.1 21.9 37.2 18.6 20.8 55.8 32.8 76.1 34.4 21.0 16.3 52.9 42.1 23.0 30.9 27.8 44.0 10.5 22.7 26.0 13.3 25.2 31.2 24.0 20.9 8.1 32.4 24.6 20.1 33.2 23.2 20.0 20.7 22.2 9.7 17.3 20.4 32.9 20.4 19.2 19.8 15.0 20.1 16.6 16.4 22.6 19.7 201.0 160.3 230.1 157.4 176.6 92.4 112.2 71.3 114.9 220.1 87.8 86.7 277.8 60.1 101.5 71.7 212.7 72.2 176.9 49.0 23.5 91.8 4.7 103.1 195.5 162.8 126.8 105.8 197.8 83.1 51.0 134.3 114.2 137.3 113.1 261.4 97.8 56.7 70.9 158.2 246.9 78.0 69.2 87.0 101.6 12.7 162.4 113.1 62.2 195.8 149.0 112.3 183.4 202.5 237.1 92.0 47.6 208.0 183.9 120.8 49.2 37.2 102.6 245.4 92.1 174.7 160.0 19.8 52.8 78.7 84.4 59.8 158.0 312.4 73.3 112.0 AXIN1 PPP1R49 ENSG00000103126 "Axin 1" O15169 16 287440-352723 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Wnt signaling pathway" "Developmental protein" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB012987 Approved Supported Nucleoli,Vesicles NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 63: NK-cells & T-cells - Immune response" "Nucleoli, Vesicles" "CAB012987: AB_2533178" "unprognostic (3.81e-2)" "unprognostic (1.56e-1)" "unprognostic (1.90e-1)" "unprognostic (7.64e-2)" "unprognostic (1.90e-1)" "unprognostic (1.06e-1)" "prognostic unfavorable (3.38e-5)" "unprognostic (1.23e-1)" "unprognostic (3.58e-1)" "unprognostic (1.56e-1)" "unprognostic (4.58e-2)" "unprognostic (2.02e-2)" "unprognostic (1.57e-1)" "unprognostic (4.41e-2)" "unprognostic (1.94e-1)" "unprognostic (1.23e-2)" "unprognostic (1.03e-1)" 11.9 9.3 10.5 9.2 10.8 23.0 11.5 14.8 12.5 12.9 9.1 17.1 12.3 13.2 3.1 16.3 11.8 6.2 11.6 10.0 9.2 11.6 11.2 13.7 10.5 10.2 10.2 13.8 13.0 7.2 12.6 5.8 9.8 12.9 6.9 2.6 11.5 6.0 21.1 20.1 15.0 5.4 9.2 15.0 12.9 11.8 10.1 12.5 11.9 7.0 6.6 14.5 13.1 11.9 18.1 25.6 13.4 23.7 9.8 9.0 28.0 11.9 10.8 16.1 13.8 37.9 20.4 27.7 18.0 12.3 19.4 25.4 21.1 18.5 7.2 27.5 34.6 18.0 21.9 27.6 16.6 20.9 19.3 9.0 31.7 16.6 20.3 14.1 10.7 19.8 45.6 14.8 7.4 48.1 22.7 14.5 30.6 21.6 15.4 42.4 12.2 38.8 12.2 10.5 30.4 18.6 22.6 24.9 38.3 10.0 16.5 26.1 12.4 15.9 17.0 18.5 17.5 17.3 18.1 34.2 7.5 13.7 15.9 1.2 0.9 5.0 8.3 0.8 7.6 1.5 2.4 5.8 0.7 1.2 2.4 3.4 2.7 3.5 0.6 1.2 2.6 2.3 10.5 10.8 14.8 12.5 10.0 9.2 10.2 10.2 9.8 9.2 10.1 11.9 7.9 3.2 8.6 4.9 5.7 18.4 7.6 8.5 5.7 4.3 11.2 9.5 4.9 5.7 7.2 3.7 0.0 3.5 30.1 27.4 0.0 7.2 1.4 10.2 7.0 6.3 10.8 8.6 18.5 6.9 27.5 6.7 15.3 14.4 10.8 10.5 5.7 5.1 7.5 5.0 12.7 15.1 6.1 6.2 9.0 2.1 5.3 6.7 10.6 1.0 5.7 4.5 28.8 8.5 8.9 11.0 12.2 4.9 7.0 13.4 11.1 2.4 7.7 5.7 13.1 8.7 7.6 5.5 8.8 7.2 15.2 3.7 12.4 5.0 15.7 10.5 AXIN2 "DKFZp781B0869, MGC126582" ENSG00000168646 "Axin 2" Q9Y2T1 17 65528563-65561648 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Wnt signaling pathway" "Developmental protein" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Early spermatids: 33.7;Extravillous trophoblasts: 102.6" "Cancer enhanced" "Detected in all" "colorectal cancer: 33.4" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "basophil: 3.2" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "AF22: 27.2;CACO-2: 52.3;Hep G2: 78.8;OE19: 86.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB012283, CAB017783" Approved Uncertain "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 89: Fibroblasts - ECM organization" "Cluster 39: CACO-2 - Unknown function" "Cluster 38: Extravillous trophoblasts - Unknown function" "Nucleoplasm, Plasma membrane" Cytosol "CAB012283: AB_2290204, CAB017783: " "unprognostic (1.31e-2)" "unprognostic (1.29e-1)" "unprognostic (1.05e-2)" "unprognostic (3.45e-3)" "unprognostic (4.48e-1)" "unprognostic (9.81e-2)" "unprognostic (1.12e-2)" "unprognostic (1.82e-1)" "unprognostic (4.57e-2)" "unprognostic (8.84e-3)" "prognostic favorable (6.58e-4)" "unprognostic (1.98e-1)" "unprognostic (1.42e-1)" "unprognostic (3.45e-2)" "unprognostic (2.10e-1)" "unprognostic (2.74e-1)" "unprognostic (1.25e-1)" 8.7 10.9 6.8 5.4 6.9 0.9 5.3 7.9 7.9 17.2 5.5 12.3 7.1 23.9 5.9 5.9 19.8 6.6 8.0 9.4 6.2 3.7 2.7 17.0 3.5 8.5 7.9 15.0 4.2 4.2 6.2 18.4 5.3 14.0 14.6 3.4 5.2 8.9 14.6 14.9 7.4 17.3 7.3 7.4 13.6 6.7 11.0 17.3 12.3 7.8 2.7 11.4 8.0 5.6 0.0 13.9 27.2 0.5 9.6 4.1 12.0 0.4 1.3 0.9 1.7 52.3 5.0 1.0 1.7 8.0 1.0 0.4 5.7 0.1 1.9 2.4 3.1 0.0 2.4 78.8 1.0 0.1 0.1 2.4 2.1 2.2 0.6 1.6 2.4 5.1 0.2 1.2 1.4 0.3 13.9 0.1 5.3 86.9 0.6 9.9 1.6 0.1 2.6 0.3 8.4 5.5 0.5 0.3 4.8 20.0 1.0 0.3 6.3 5.3 9.6 7.6 1.7 0.1 3.0 3.8 2.5 0.6 2.6 3.2 0.0 0.0 0.1 0.0 0.4 0.5 1.1 0.2 0.0 1.8 2.3 0.4 0.0 1.0 0.0 0.0 0.0 0.3 6.8 6.9 7.9 7.9 9.4 6.2 8.5 7.9 5.3 7.3 11.0 5.6 2.4 0.0 9.0 9.8 1.0 11.2 2.2 1.0 11.4 3.7 5.2 8.1 8.7 1.5 8.1 0.0 4.2 18.1 0.7 15.2 0.0 1.4 33.7 7.8 15.1 5.3 5.4 0.0 8.4 0.9 102.6 10.3 5.6 16.5 0.0 3.1 1.1 2.0 3.8 1.7 8.7 17.4 0.0 0.0 7.5 17.5 6.5 0.6 17.8 9.4 1.0 3.3 0.0 8.0 2.0 0.8 18.9 10.9 0.9 2.9 1.9 0.9 1.3 2.5 13.1 1.6 10.6 6.2 12.9 3.3 5.5 14.2 4.6 3.6 19.8 1.3 B2M ENSG00000166710 Beta-2-microglobulin P61769 15 44711487-44718851 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins, Transporters" Immunity "Amyloidosis, Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "monocytes: 31919.3;NK-cells: 24726.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002572, HPA006361" Enhanced Enhanced "Golgi apparatus,Plasma membrane,Cytosol" "Secreted to blood" NA NA 1790000000 2100000000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 64: Macrophages - Immune response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 3: Monocytes - Immune response regulation" "Golgi apparatus, Plasma membrane" Cytosol "CAB002572: AB_563434, HPA006361: AB_1078278" "unprognostic (9.45e-2)" "unprognostic (5.63e-2)" "unprognostic (3.02e-1)" "unprognostic (8.14e-2)" "unprognostic (1.18e-1)" "unprognostic (4.82e-2)" "unprognostic (1.81e-2)" "unprognostic (1.25e-1)" "unprognostic (2.69e-2)" "unprognostic (1.12e-1)" "unprognostic (2.44e-3)" "unprognostic (2.02e-2)" "unprognostic (4.77e-2)" "unprognostic (2.39e-1)" "unprognostic (5.25e-2)" "unprognostic (1.97e-2)" "unprognostic (2.17e-2)" 3160.2 3214.7 697.6 5686.5 705.1 7839.2 2606.9 711.8 1145.0 2539.9 789.6 5139.0 5180.7 2192.2 1735.6 2283.9 1648.3 4948.8 2327.2 651.0 769.9 2462.6 6206.2 6159.2 9311.8 889.5 763.2 1945.7 1310.9 1940.5 318.4 3502.0 815.3 2345.0 5593.5 139.3 5657.1 1784.5 931.7 3015.6 5693.3 2545.3 838.3 7896.1 4878.2 615.6 771.9 4217.4 2340.8 2026.5 5333.4 5753.1 549.4 909.5 1735.4 378.9 226.0 633.6 4348.7 4719.4 1662.5 2045.5 4961.9 3609.7 6561.4 425.3 5417.9 554.8 2567.9 1948.8 2410.2 2537.0 497.2 878.7 1226.2 4762.2 435.9 2956.9 2263.6 600.3 3609.3 2074.5 3328.6 2735.9 609.8 1075.7 1044.4 2442.6 1884.1 965.4 611.9 3649.1 2195.5 476.9 1518.4 3213.8 206.5 629.8 1014.3 2240.2 1926.6 4789.2 2425.5 3486.4 254.1 179.1 1288.4 1571.2 1338.5 394.3 655.3 6180.6 2548.7 4531.4 676.5 5389.2 2193.3 4771.7 7118.6 1683.1 5384.6 3783.6 2567.3 48105.4 18117.1 33178.9 20639.1 17775.0 20836.8 15768.0 23783.0 22245.1 9978.8 11988.4 17122.9 22791.8 50453.6 18779.6 19034.9 12052.6 29659.1 56957.2 697.6 705.1 711.8 1145.0 651.0 769.9 889.5 763.2 815.3 838.3 771.9 909.5 12048.3 3387.8 3505.1 28.7 8472.8 7843.7 3197.1 8420.8 1628.8 33.3 2399.5 2015.2 1068.8 3593.1 5347.4 2100.3 27.1 1354.6 14028.8 8753.6 1038.9 13898.6 43.1 2073.7 2414.0 8385.6 2266.0 2087.2 7.3 9034.5 4397.5 3691.1 1981.7 2282.2 3029.5 1270.6 6835.7 3832.6 11985.7 5.0 22.0 5982.6 8701.4 12536.8 14507.0 158.8 3018.0 10687.9 6744.8 368.2 31919.3 322.0 24726.3 95.0 129.2 10115.7 7085.6 1688.8 11026.6 5300.4 18327.7 3122.5 8367.9 52.5 4016.7 2055.2 4107.1 64.2 72.1 1541.4 8619.8 804.8 14266.2 3229.8 3063.4 8248.6 BAX BCL2L4 ENSG00000087088 "BCL2 associated X, apoptosis regulator" Q07812 19 48954815-48961798 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transporters" "Apoptosis, Host-virus interaction" "Cancer-related genes, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004206, HPA027878" Approved NA NA 1100000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 28: BEWO - Transcription regulation" "Cluster 10: Non-specific - Unknown function" "CAB004206: AB_626729, HPA027878: AB_10601687" "unprognostic (4.11e-2)" "unprognostic (4.70e-2)" "unprognostic (1.50e-1)" "unprognostic (6.23e-2)" "unprognostic (1.70e-1)" "unprognostic (2.82e-1)" "prognostic unfavorable (1.63e-5)" "unprognostic (4.92e-2)" "unprognostic (1.09e-1)" "unprognostic (4.71e-2)" "unprognostic (3.66e-2)" "unprognostic (8.10e-2)" "unprognostic (1.19e-2)" "unprognostic (7.83e-2)" "unprognostic (1.08e-1)" "unprognostic (4.47e-3)" "unprognostic (6.22e-2)" 30.2 30.4 24.4 59.2 26.8 65.7 27.2 25.5 29.3 27.6 23.9 78.1 68.2 29.9 23.2 35.8 33.2 37.6 22.6 24.5 25.5 31.0 33.4 46.0 59.5 27.1 25.4 19.6 32.7 26.1 15.9 43.3 27.0 25.7 58.8 7.2 26.5 27.0 18.1 29.8 64.6 36.3 26.1 60.0 43.8 12.4 26.3 83.2 23.4 11.8 44.7 46.7 26.1 27.1 177.4 286.0 170.1 150.4 165.4 161.7 280.2 117.8 233.4 151.7 210.6 76.4 168.6 214.6 53.9 181.2 141.3 93.8 78.0 229.0 125.7 166.6 181.0 91.9 56.6 288.0 265.7 96.3 280.9 222.3 161.7 126.1 75.5 183.3 354.6 83.4 91.4 86.0 264.8 123.1 157.6 150.3 132.8 171.3 82.5 109.2 113.1 82.4 161.0 168.4 97.4 114.7 99.2 69.8 57.4 240.6 56.2 171.2 210.2 194.0 212.1 120.1 165.1 97.9 136.6 145.0 118.1 129.2 275.1 5.2 12.1 13.4 6.5 18.4 4.6 7.3 3.7 7.1 12.2 5.9 2.4 6.0 13.1 12.2 20.9 12.5 7.5 8.4 24.4 26.8 25.5 29.3 24.5 25.5 27.1 25.4 27.0 26.1 26.3 27.1 83.2 3.2 4.8 8.1 164.6 54.8 63.8 160.8 101.3 19.3 64.1 67.4 8.4 78.6 98.7 60.7 10.4 126.0 130.2 152.9 74.3 122.7 1.1 43.4 65.7 83.7 114.0 79.3 7.9 96.2 157.9 57.0 114.2 46.0 43.9 151.7 59.3 28.1 263.6 30.3 8.3 102.7 209.5 121.8 143.0 4.0 48.1 148.3 83.6 3.7 295.3 43.9 140.1 7.5 13.8 139.4 177.0 38.4 96.2 126.6 229.8 227.4 66.4 15.9 46.0 35.8 259.4 20.3 38.1 92.0 56.4 101.9 149.4 175.5 149.7 86.7 BCL2 "Bcl-2, PPP1R50" ENSG00000171791 "BCL2 apoptosis regulator" P10415 18 63123346-63320128 "Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Apoptosis "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 271.6;Inhibitory neurons: 102.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in many" 18 "B-cells: 5.4;T-cells: 8.5" "Cell line enhanced" "Detected in many" "HDLM-2: 44.2;HL-60: 43.7;Karpas-707: 72.9;U-266/70: 217.4" "Low region specificity" "Detected in all" "CAB000003, HPA055295" Enhanced Supported "Nucleoplasm,Nuclear membrane" NA NA "Cluster 13: T-cells - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 29: U-266 - Adaptive immune response" "Cluster 64: Astrocytes - Nervous system maintenance" "Nuclear membrane" Nucleoplasm "CAB000003: AB_2064429, HPA055295: AB_2682776" "unprognostic (1.11e-3)" "prognostic favorable (5.13e-5)" "unprognostic (5.49e-2)" "unprognostic (1.19e-1)" "unprognostic (1.89e-1)" "unprognostic (3.05e-3)" "unprognostic (2.88e-1)" "unprognostic (1.93e-3)" "unprognostic (4.78e-2)" "unprognostic (2.08e-1)" "unprognostic (2.23e-2)" "unprognostic (8.51e-2)" "prognostic favorable (1.29e-8)" "unprognostic (6.67e-2)" "unprognostic (1.19e-1)" "prognostic unfavorable (2.47e-4)" "unprognostic (2.63e-1)" 12.8 1.9 5.5 10.2 7.8 5.0 9.6 4.7 3.4 10.7 0.0 6.2 4.4 11.6 2.9 5.9 11.8 6.5 5.3 2.9 6.6 6.7 2.1 3.7 14.7 11.2 7.9 14.5 3.1 13.0 4.7 4.6 7.5 6.4 5.5 2.1 3.7 7.0 16.5 4.8 8.1 6.6 7.9 17.9 3.8 1.5 8.2 18.3 24.0 8.8 14.6 5.4 7.7 5.7 1.7 0.3 6.8 5.9 6.7 1.3 2.4 1.0 0.7 2.4 2.0 3.5 0.4 0.3 1.1 0.9 4.7 0.4 6.7 0.9 1.5 44.2 1.6 0.5 2.0 0.7 2.0 43.7 5.6 1.7 0.8 3.3 5.8 1.1 0.7 4.3 0.8 72.9 2.2 1.4 9.8 10.7 1.5 0.8 1.3 39.5 1.9 26.5 7.4 8.5 7.2 6.4 0.3 0.3 8.5 1.4 0.3 29.9 0.3 9.9 3.3 0.9 5.1 217.4 40.1 2.9 1.9 24.9 6.0 0.3 0.0 0.0 1.9 0.0 7.6 5.4 6.3 3.4 0.1 3.1 3.3 3.2 0.0 0.2 0.3 0.2 8.5 1.3 5.5 7.8 4.7 3.4 2.9 6.6 11.2 7.9 7.5 7.9 8.2 5.7 7.1 0.0 1.1 271.6 84.9 19.5 33.6 1.6 13.6 1.9 39.7 19.7 17.4 18.6 2.4 7.3 0.0 14.0 39.9 2.7 15.6 3.7 0.4 9.8 9.8 5.9 5.4 3.8 60.7 0.0 0.7 15.8 5.6 24.9 15.8 38.8 3.9 1.2 9.4 0.0 102.3 10.5 24.4 15.0 29.6 1.9 8.7 29.0 46.2 88.1 19.7 18.8 18.6 76.4 56.7 0.2 5.9 13.9 50.1 41.6 0.9 18.0 0.1 0.6 26.3 48.8 19.7 0.3 1.3 6.2 17.6 49.1 76.1 24.1 9.8 76.2 BCL6 "BCL5, BCL6A, LAZ3, ZBTB27, ZNF51" ENSG00000113916 "BCL6 transcription repressor" P41182 3 187721377-187745725 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Immunity, Inflammatory response, Transcription, Transcription regulation" "Activator, DNA-binding, Repressor" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 485.9" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 205.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "neutrophil: 269.1;non-classical monocyte: 76.4" "Group enriched" "Detected in all" 7 "granulocytes: 269.1;monocytes: 76.4" "Cell line enhanced" "Detected in many" "Daudi: 166.4;HSkMC: 113.9;U-698: 231.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000307, HPA004899, HPA050645" Enhanced Supported Nucleoplasm NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 50: Fibroblasts - ECM organization" Nucleoplasm "CAB000307: AB_2063451, HPA004899: AB_1078273, HPA050645: AB_2681199" "unprognostic (5.36e-2)" "unprognostic (3.29e-2)" "unprognostic (1.63e-3)" "unprognostic (2.49e-1)" "unprognostic (2.85e-1)" "unprognostic (6.34e-3)" "unprognostic (2.62e-2)" "unprognostic (3.33e-3)" "unprognostic (8.75e-2)" "unprognostic (2.04e-2)" "unprognostic (1.63e-3)" "unprognostic (1.29e-1)" "prognostic unfavorable (1.27e-9)" "unprognostic (5.22e-2)" "unprognostic (7.82e-2)" "unprognostic (5.67e-2)" "unprognostic (2.58e-2)" 143.0 49.4 54.3 53.9 53.4 123.7 126.9 85.9 57.9 100.0 35.0 87.1 7.5 68.1 16.4 44.6 140.7 45.6 72.1 50.9 68.7 37.0 65.3 110.5 56.0 104.1 69.4 65.6 49.2 11.3 44.8 15.3 74.2 57.5 10.3 34.2 70.3 22.2 485.9 160.7 34.4 43.0 55.9 106.3 58.4 18.6 69.0 43.2 50.4 96.6 47.7 90.6 81.5 64.1 5.1 13.8 14.4 3.2 98.1 78.0 14.9 16.5 39.2 18.4 19.4 9.4 7.6 166.4 11.5 21.0 11.7 7.7 4.4 10.6 15.3 33.8 5.1 0.2 6.7 22.5 51.5 2.1 0.9 113.9 68.8 22.7 32.9 60.1 10.2 4.2 1.6 27.6 18.2 5.7 5.5 1.3 1.4 3.0 10.3 45.4 7.0 0.8 13.6 23.2 3.1 0.2 18.8 8.1 11.0 30.2 35.3 5.9 21.2 43.7 7.1 16.6 7.5 21.2 7.2 231.6 24.2 6.0 31.7 8.8 33.0 18.9 5.5 37.3 5.4 6.6 3.4 5.0 24.6 15.3 2.1 2.3 269.1 3.9 76.4 4.0 3.1 30.7 54.3 53.4 85.9 57.9 50.9 68.7 104.1 69.4 74.2 55.9 69.0 64.1 35.7 19.2 67.4 66.0 22.7 47.3 14.7 18.8 205.5 10.9 55.3 54.6 71.4 14.3 28.9 16.5 20.9 1.4 36.0 3.5 0.0 12.2 13.3 36.2 26.7 25.0 4.8 3.2 7.6 12.5 2.7 57.3 12.2 51.4 11.4 9.4 15.0 51.2 11.9 0.0 19.6 2.3 16.2 67.5 74.4 8.6 28.9 48.1 35.6 7.5 16.8 39.1 1.0 50.8 7.8 7.9 0.3 18.8 14.2 27.9 1.2 1.5 29.5 9.7 32.9 77.0 84.9 0.4 1.2 72.4 61.5 4.1 30.0 10.3 2.8 29.7 BMI1 "PCGF4, RNF51" ENSG00000168283 "BMI1 proto-oncogene, polycomb ring finger" P35226 10 22321099-22331484 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins" "Transcription, Transcription regulation" "Chromatin regulator, Repressor" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 134.0;Late spermatids: 165.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 508.3;U-937: 583.9" "CAB011120, HPA030471, HPA030472" Supported Approved "Nucleoplasm,Nucleoli,Nuclear bodies,Cytosol" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 44: HDLM-2 - Immune response" "Cluster 31: Spermatids - Spermatogenesis" "Nucleoplasm, Nuclear bodies" "Nucleoli, Cytosol" "CAB011120: , HPA030471: AB_2673491, HPA030472: AB_10601090" "unprognostic (5.44e-1)" "unprognostic (2.98e-1)" "unprognostic (4.24e-2)" "unprognostic (4.37e-2)" "unprognostic (2.76e-3)" "unprognostic (6.93e-2)" "prognostic unfavorable (2.60e-8)" "unprognostic (9.43e-2)" "unprognostic (7.95e-2)" "unprognostic (7.84e-2)" "unprognostic (8.23e-2)" "unprognostic (1.56e-1)" "unprognostic (7.44e-2)" "unprognostic (9.73e-2)" "unprognostic (8.56e-2)" "unprognostic (7.91e-3)" "unprognostic (3.41e-2)" 29.0 31.1 26.6 25.1 35.1 21.9 36.0 29.9 42.4 27.6 28.2 26.2 19.7 30.7 29.7 21.9 22.6 23.9 20.5 25.0 27.8 26.0 35.6 23.4 27.7 29.5 30.1 21.7 25.7 56.9 25.0 28.7 31.6 33.7 21.5 40.4 19.9 26.1 44.4 14.4 20.8 36.2 29.9 36.2 22.5 35.3 28.1 24.9 23.9 35.5 27.0 23.8 14.8 45.4 74.9 36.1 41.2 12.7 68.9 54.6 40.5 49.7 22.2 37.3 43.5 37.6 93.4 38.1 32.8 45.6 42.2 26.1 59.1 35.0 45.4 508.3 72.8 104.7 28.7 42.9 41.1 39.8 55.7 35.5 58.8 41.2 45.3 47.0 26.2 62.1 105.4 63.3 48.6 30.2 106.9 11.4 9.3 36.3 83.4 79.6 57.1 37.3 35.3 25.2 33.8 66.0 32.7 42.5 57.3 17.8 38.5 153.8 56.4 41.4 122.6 99.6 67.6 76.1 110.8 83.1 59.5 583.9 27.4 15.1 1.3 2.5 5.2 3.0 7.0 4.4 5.3 5.0 0.9 2.2 4.4 4.3 0.6 5.2 2.1 1.6 4.1 2.0 26.6 35.1 29.9 42.4 25.0 27.8 29.5 30.1 31.6 29.9 28.1 45.4 18.9 25.6 24.0 0.0 23.1 15.9 20.5 12.4 22.8 20.9 24.4 20.3 19.0 22.8 19.8 12.9 8.4 12.7 14.2 5.6 13.7 16.3 134.0 12.1 25.3 24.0 13.2 19.1 0.0 18.2 22.2 19.8 7.7 9.8 12.0 12.6 28.5 30.7 9.9 30.3 0.0 9.9 14.2 19.7 25.6 165.1 36.1 13.8 37.4 0.0 17.5 13.9 15.5 0.0 0.0 22.9 7.3 36.5 33.9 29.1 4.6 13.0 16.9 15.2 19.7 26.5 28.6 19.8 22.2 11.2 14.6 6.7 22.4 17.0 10.3 20.4 BRAF BRAF1 ENSG00000157764 "B-Raf proto-oncogene, serine/threonine kinase" P15056 7 140719327-140924929 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Allosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Cardiomyopathy, Deafness, Disease variant, Ectodermal dysplasia, FDA approved drug targets, Mental retardation, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 252.3;Inhibitory neurons: 242.4;Oligodendrocyte precursor cells: 206.1;Oligodendrocytes: 202.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001328, CAB004552, HPA071048" Approved Approved Vesicles,Cytosol No No "Cluster 15: NK-cells - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 29: U-266 - Adaptive immune response" "Cluster 52: Non-specific - Transcription" Vesicles Cytosol "CAB004552: AB_626760, HPA001328: AB_1078296, HPA071048: AB_2686336" "unprognostic (2.98e-3)" "unprognostic (5.66e-2)" "unprognostic (2.20e-2)" "unprognostic (2.66e-3)" "unprognostic (2.44e-1)" "unprognostic (1.48e-2)" "unprognostic (2.07e-2)" "unprognostic (4.23e-2)" "unprognostic (4.07e-2)" "unprognostic (1.58e-2)" "unprognostic (6.53e-2)" "unprognostic (1.91e-2)" "unprognostic (3.79e-3)" "unprognostic (2.08e-1)" "unprognostic (1.76e-1)" "unprognostic (8.01e-2)" "unprognostic (5.46e-2)" 8.8 5.8 6.3 5.6 7.7 15.9 8.8 12.5 8.7 8.2 5.4 8.6 4.7 8.3 8.3 7.5 8.0 5.8 7.6 8.3 6.7 7.6 6.6 9.9 6.9 4.0 3.6 9.8 8.3 11.5 9.0 7.2 4.6 8.2 5.4 17.0 7.2 5.9 8.6 10.4 6.9 6.0 3.1 6.7 7.8 13.7 5.2 8.7 10.2 8.4 6.4 9.9 8.5 6.7 6.3 5.2 7.7 9.4 9.1 11.8 12.3 6.8 7.5 5.4 7.6 5.7 6.7 10.8 5.0 7.3 8.4 3.4 6.8 5.5 10.0 9.8 5.4 7.1 5.1 5.2 7.6 11.7 6.8 7.9 6.1 6.0 12.0 8.2 6.6 7.7 11.3 19.1 9.8 3.3 15.6 12.0 6.9 6.2 3.1 10.1 6.5 8.9 5.3 11.9 8.9 7.3 7.9 4.9 7.3 7.5 4.5 7.8 9.7 5.9 4.3 12.9 5.5 21.6 12.9 16.7 9.7 11.3 6.6 1.9 1.0 4.1 1.5 0.9 1.0 1.3 1.5 1.2 0.8 1.1 2.6 1.3 2.0 3.5 1.3 1.0 1.5 0.6 6.3 7.7 12.5 8.7 8.3 6.7 4.0 3.6 4.6 3.1 5.2 6.7 43.4 22.4 45.7 151.1 58.4 21.5 24.6 6.0 23.3 29.7 31.2 21.2 19.8 10.0 18.7 25.8 35.5 15.7 73.5 8.8 7.9 14.3 68.6 50.6 37.4 23.4 19.2 14.9 252.3 9.8 12.9 22.0 21.9 69.2 24.7 45.5 9.3 9.6 9.4 25.2 242.4 9.8 8.2 13.6 37.1 36.5 16.4 30.1 16.0 126.5 14.6 11.3 15.5 206.1 202.6 15.4 8.1 10.1 48.7 23.8 8.0 13.4 20.0 33.0 6.6 24.1 24.7 43.8 26.0 14.5 24.0 75.5 41.4 30.9 8.7 33.4 BRCA1 "BRCC1, FANCS, PPP1R53, RNF53" ENSG00000012048 "BRCA1 DNA repair associated" P38398 17 43044295-43170245 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, DNA damage, DNA recombination, DNA repair, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, DNA-binding, Transferase" "Cancer-related genes, Disease variant, Fanconi anemia, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Erythroid cells: 42.5;Granulosa cells: 38.2;Spermatocytes: 105.8;Spermatogonia: 73.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "basophil: 6.8;classical monocyte: 14.7;intermediate monocyte: 4.7;myeloid DC: 10.9;neutrophil: 11.3" "Group enriched" "Detected in all" 6 "dendritic cells: 10.9;granulocytes: 11.3;monocytes: 14.7" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB001946, HPA004840, HPA034966, HPA057371" Approved Supported "Nucleoplasm,Nuclear bodies" NA Yes "Cluster 25: Monocytes - Inflammatory response" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "Nucleoplasm, Nuclear bodies" "CAB001946: , HPA004840: , HPA034966: AB_10795287, HPA057371: AB_2732611" "unprognostic (7.87e-3)" "unprognostic (6.97e-2)" "unprognostic (3.53e-3)" "unprognostic (2.39e-1)" "unprognostic (5.42e-2)" "unprognostic (7.07e-3)" "unprognostic (1.56e-3)" "unprognostic (4.14e-3)" "unprognostic (9.62e-3)" "unprognostic (2.47e-1)" "unprognostic (5.53e-3)" "unprognostic (1.28e-1)" "unprognostic (1.08e-4)" "unprognostic (1.08e-3)" "unprognostic (1.48e-1)" "unprognostic (2.12e-1)" "unprognostic (8.31e-2)" 3.1 1.8 4.2 7.5 7.2 13.0 3.6 4.7 5.2 2.7 2.7 6.8 3.2 3.1 2.2 4.0 3.7 1.9 3.0 3.6 4.1 2.0 5.6 3.2 10.3 5.6 5.0 2.8 2.8 5.9 2.8 3.8 6.0 2.4 7.4 8.2 3.2 1.6 4.2 6.0 5.1 3.9 3.7 3.9 3.6 13.0 5.5 14.5 7.8 3.7 11.2 2.8 2.4 10.8 44.1 69.1 37.8 30.1 6.0 13.4 36.6 50.6 21.5 41.9 39.3 42.3 33.4 100.8 9.1 19.0 49.0 49.5 51.9 28.3 69.5 46.9 38.0 48.1 54.0 37.1 1.3 86.0 39.9 3.8 4.5 63.1 20.0 10.6 22.3 46.6 73.7 42.2 39.7 30.0 72.0 27.8 20.5 29.1 18.7 49.0 79.8 40.8 15.4 42.1 25.8 27.4 38.8 12.5 19.4 25.5 33.9 39.6 13.8 37.2 29.6 49.0 53.2 20.1 51.2 75.5 29.6 49.6 39.4 6.8 14.7 2.2 1.5 4.7 1.5 1.2 1.5 1.2 10.9 2.1 1.3 1.5 11.3 1.5 2.0 1.7 0.5 17.5 4.2 7.2 4.7 5.2 3.6 4.1 5.6 5.0 6.0 3.7 5.5 10.8 5.0 0.0 2.8 9.4 5.8 2.9 4.5 1.9 1.2 10.3 4.4 5.2 10.1 5.7 3.5 1.8 22.9 12.8 8.1 6.2 0.0 3.0 11.9 14.0 6.3 4.7 0.0 42.5 3.0 1.1 18.2 7.4 6.1 4.2 8.2 38.2 5.3 18.3 10.1 11.8 4.4 7.5 0.0 3.9 2.8 8.0 2.5 6.4 0.0 4.7 4.9 2.4 5.2 3.0 18.7 1.7 2.4 1.5 16.6 2.3 1.1 1.0 10.0 22.8 6.6 13.7 5.5 105.8 73.5 8.2 2.3 4.0 4.7 9.7 12.7 3.4 BRCA2 "BRCC2, FACD, FAD, FAD1, FANCD, FANCD1, XRCC11" ENSG00000139618 "BRCA2 DNA repair associated" P51587 13 32315086-32400268 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cell cycle, DNA damage, DNA recombination, DNA repair" DNA-binding "Cancer-related genes, Disease variant, Fanconi anemia, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 5.8;lymphoid tissue: 3.1;testis: 2.7" "Cell type enhanced" "Detected in many" "Spermatocytes: 115.4;Spermatogonia: 85.6" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" HPA026815 Uncertain Supported Nucleoplasm,Cytosol Yes No "Cluster 45: Eosinophils - Innate immune response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm Cytosol "HPA026815: AB_10602692" "unprognostic (9.36e-2)" "unprognostic (2.50e-1)" "unprognostic (4.50e-3)" "unprognostic (1.06e-2)" "unprognostic (5.40e-2)" "unprognostic (2.26e-2)" "unprognostic (1.37e-2)" "unprognostic (1.15e-1)" "unprognostic (1.60e-2)" "unprognostic (2.01e-1)" "unprognostic (6.97e-3)" "unprognostic (4.06e-2)" "unprognostic (3.07e-9)" "unprognostic (2.36e-2)" "unprognostic (1.18e-1)" "unprognostic (1.88e-1)" "unprognostic (1.32e-1)" 0.2 0.1 0.0 1.3 0.0 5.8 0.5 0.0 0.0 0.2 0.2 0.7 0.5 0.3 0.0 0.5 0.1 0.3 0.0 0.0 0.0 0.1 0.3 0.3 2.1 0.1 0.1 0.1 0.1 0.0 0.0 1.0 0.1 0.1 0.8 0.0 0.2 0.0 0.0 0.7 0.5 0.3 0.1 0.9 0.6 2.7 0.2 3.1 0.2 0.0 2.0 0.5 0.2 0.1 4.7 4.0 6.0 5.0 0.6 1.4 7.0 4.8 3.1 5.5 5.0 10.6 6.0 15.9 3.2 2.1 7.6 6.1 5.5 2.9 10.5 10.5 3.1 10.3 2.5 3.5 0.1 15.4 4.9 0.2 0.0 10.3 6.9 0.4 4.5 8.1 7.0 5.5 6.4 5.1 11.8 8.3 8.3 4.9 2.3 11.4 17.3 3.0 1.4 5.4 2.4 4.6 5.9 2.4 2.2 2.2 2.9 7.3 1.3 6.3 6.8 7.0 6.7 2.0 3.3 8.0 2.7 5.7 5.8 0.0 0.3 1.5 0.5 0.7 0.1 1.7 0.4 0.4 0.3 2.2 0.5 0.4 0.8 0.5 0.8 3.0 1.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.2 0.1 4.4 9.6 2.6 0.0 12.4 2.5 3.3 2.5 2.2 0.0 4.3 3.3 1.9 0.0 1.8 0.0 0.0 14.1 10.5 4.8 0.0 2.5 5.2 4.4 6.3 5.5 1.2 29.5 0.7 1.6 12.7 5.8 10.7 4.6 3.8 26.9 1.4 0.8 9.5 0.0 0.5 4.4 0.0 7.5 11.0 4.4 2.1 14.4 3.6 4.7 20.1 0.3 0.0 0.0 0.6 1.2 1.8 1.2 27.8 1.2 1.0 0.6 2.9 0.0 13.1 8.3 5.3 115.4 85.6 8.0 1.3 5.5 7.9 4.2 7.8 2.3 CADM1 "BL2, IGSF4, IGSF4A, Necl-2, NECL2, RA175, ST17, SYNCAM, SYNCAM1, TSLC1" ENSG00000182985 "Cell adhesion molecule 1" Q9BY67 11 115169218-115504957 "Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Cell adhesion, Differentiation, Host-virus interaction, Immunity, Spermatogenesis" "Developmental protein" "Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "retina: 287.7" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 464.8;Astrocytes: 980.7;Bipolar cells: 566.6;Muller glia cells: 489.9;Oligodendrocyte precursor cells: 676.5;Oligodendrocytes: 622.8;Rod photoreceptor cells: 759.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "gdT-cell: 8.0;myeloid DC: 8.1" "Group enriched" "Detected in many" 5 "dendritic cells: 8.1;T-cells: 8.0" "Cell line enhanced" "Detected in many" "CACO-2: 294.7;WM-115: 187.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB037266 Enhanced Supported "Cell Junctions" NA NA 220000000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 77: Retina - Visual perception" "Cluster 39: CACO-2 - Unknown function" "Cluster 56: Bipolar cells - Visual perception" "Cell Junctions" "CAB037266: AB_532287" "unprognostic (1.50e-1)" "unprognostic (2.15e-1)" "unprognostic (1.92e-2)" "prognostic favorable (1.32e-4)" "unprognostic (4.11e-3)" "unprognostic (1.50e-1)" "unprognostic (2.75e-3)" "unprognostic (1.13e-2)" "unprognostic (1.77e-1)" "unprognostic (2.67e-1)" "unprognostic (6.61e-3)" "unprognostic (9.22e-2)" "unprognostic (2.92e-3)" "unprognostic (1.77e-2)" "unprognostic (1.54e-1)" "unprognostic (3.67e-2)" "unprognostic (5.40e-2)" 7.1 29.9 46.9 6.1 59.2 0.4 17.0 78.7 53.0 21.3 6.1 11.7 7.8 17.4 103.7 12.6 22.6 12.1 25.7 47.6 57.4 29.1 65.3 72.0 14.1 41.1 40.1 12.3 16.0 56.6 26.0 37.9 44.6 15.2 8.1 287.7 38.0 28.0 7.2 10.9 8.8 8.6 30.3 8.0 12.5 50.5 55.8 8.6 69.7 8.1 14.6 13.1 4.8 38.0 0.4 23.3 25.6 0.1 0.0 0.0 0.1 24.1 41.1 3.1 0.3 294.7 26.1 0.0 75.9 36.5 25.2 4.8 4.8 27.4 2.0 1.0 38.3 0.0 7.8 114.5 0.3 0.1 56.5 0.0 38.6 0.0 63.8 16.5 1.1 17.3 0.0 2.7 4.3 19.3 20.0 0.6 24.0 0.3 0.0 0.1 0.4 61.6 44.8 0.9 50.2 107.1 0.0 25.4 21.7 102.4 92.4 1.3 0.0 2.3 44.9 23.3 13.0 64.9 98.9 18.7 36.3 0.2 187.5 0.2 0.0 0.0 8.0 0.0 3.4 1.5 2.9 2.1 8.1 0.3 0.1 1.8 0.0 0.5 0.1 0.0 4.7 1.9 46.9 59.2 78.7 53.0 47.6 57.4 41.1 40.1 44.6 30.3 55.8 38.0 14.0 464.8 195.3 980.7 6.5 20.6 26.7 2.8 19.4 566.6 22.1 22.5 61.7 34.3 27.5 36.8 350.3 71.6 6.8 1.5 11.7 39.2 189.1 88.5 6.0 10.6 7.8 5.3 301.7 2.0 5.0 13.2 3.6 126.9 24.1 36.8 2.9 45.9 36.8 30.3 310.9 2.1 4.1 8.5 20.9 224.0 5.9 14.2 44.4 60.0 13.3 489.9 2.1 676.5 622.8 9.3 0.5 4.1 88.9 38.5 0.3 8.2 8.7 759.5 0.0 13.3 11.7 55.2 23.0 9.2 23.4 32.2 8.1 5.2 4.3 13.5 CALR "cC1qR, CRT, FLJ26680, RO, SSA" ENSG00000179218 Calreticulin P27797 19 12938578-12944489 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" Chaperone "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Extravillous trophoblasts: 1717.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001513, HPA002242, CAB019952, CAB079775" Enhanced Supported "Endoplasmic reticulum" "Intracellular and membrane" NA NA 210000000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 29: Non-specific - Vesicular transport" "Cluster 32: U-937 - Innate immune response" "Cluster 38: Extravillous trophoblasts - Unknown function" "Endoplasmic reticulum" "CAB001513: , CAB019952: AB_2069792, CAB079775: AB_303403, HPA002242: AB_1078384" "unprognostic (1.49e-1)" "unprognostic (1.57e-1)" "unprognostic (8.46e-2)" "unprognostic (4.25e-2)" "unprognostic (9.44e-3)" "unprognostic (6.93e-2)" "unprognostic (2.47e-2)" "unprognostic (4.60e-2)" "unprognostic (2.61e-1)" "prognostic favorable (1.10e-4)" "unprognostic (2.07e-1)" "unprognostic (3.76e-1)" "prognostic unfavorable (1.11e-16)" "unprognostic (2.37e-1)" "unprognostic (1.96e-1)" "unprognostic (1.37e-1)" "unprognostic (5.27e-2)" 295.5 257.6 201.7 352.9 213.4 554.9 218.9 238.0 213.5 256.3 324.0 304.6 287.3 275.8 647.7 338.2 266.7 164.1 303.2 203.5 239.7 296.9 782.3 308.9 230.0 260.4 230.1 272.2 319.7 292.2 284.5 403.3 254.5 277.9 336.7 96.2 299.3 247.2 119.8 189.3 277.2 349.7 237.7 277.3 300.6 165.2 267.3 245.3 702.9 104.7 319.4 252.2 236.6 274.2 1681.4 673.6 832.5 1984.9 1110.8 861.5 724.6 2075.3 1160.8 839.6 1280.4 1044.2 1353.5 1087.2 1960.0 2528.4 1064.5 672.1 906.1 1476.5 800.7 730.0 588.1 894.3 689.0 1619.6 2667.5 3638.5 1171.8 946.8 638.7 1222.3 957.7 1472.5 1507.8 743.1 814.5 536.3 911.7 1222.3 1040.0 2511.9 808.7 952.0 970.1 777.0 770.8 1329.9 1138.3 846.9 312.4 668.4 1438.7 769.8 472.6 789.9 1014.4 1558.9 1460.6 1113.2 666.2 1533.6 938.3 644.3 569.7 985.8 1567.6 1616.3 1258.1 67.5 72.8 39.7 172.8 147.8 119.3 90.0 99.7 130.0 76.3 77.5 73.0 134.4 23.8 103.1 122.7 215.6 83.4 75.8 201.7 213.4 238.0 213.5 203.5 239.7 260.4 230.1 254.5 237.7 267.3 274.2 385.2 147.4 160.7 34.6 385.7 261.7 336.3 217.3 221.4 76.8 214.9 140.8 43.7 163.0 175.4 222.5 127.2 652.9 515.5 524.4 64.6 582.7 27.8 206.3 364.2 305.6 353.6 266.1 14.2 285.5 1717.5 422.5 289.5 348.2 207.4 341.6 312.7 612.4 789.3 35.3 23.8 595.1 93.6 208.8 433.2 30.6 318.7 378.4 213.5 31.9 229.9 316.5 360.5 28.6 31.1 410.2 462.8 311.1 1059.6 426.1 377.8 182.8 147.5 167.7 203.8 224.2 328.9 276.1 306.6 245.5 213.5 964.4 345.8 399.4 471.4 329.6 CARD11 "BIMP3, CARMA1" ENSG00000198286 "Caspase recruitment domain family member 11" Q9BXL7 7 2906142-3043867 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" Immunity "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 47.3" "Cell type enhanced" "Detected in many" "B-cells: 34.9;dendritic cells: 47.2;Microglial cells: 49.6;NK-cells: 28.8;Pancreatic endocrine cells: 24.9;Plasma cells: 26.7;T-cells: 28.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 4 "plasmacytoid DC: 31.4" "Lineage enriched" "Detected in many" 4 "dendritic cells: 31.4" "Cell line enhanced" "Detected in many" "Daudi: 122.7;K-562: 50.1;RT4: 91.4;U-698: 108.0" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA052984 Approved NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 57: B-cells - Immune response" "HPA052984: AB_2682005" "unprognostic (3.12e-2)" "unprognostic (1.75e-1)" "unprognostic (2.17e-1)" "unprognostic (8.46e-3)" "unprognostic (4.81e-1)" "unprognostic (3.44e-2)" "unprognostic (1.71e-1)" "unprognostic (2.31e-1)" "unprognostic (5.65e-2)" "unprognostic (5.11e-2)" "unprognostic (2.09e-2)" "unprognostic (3.09e-1)" "prognostic unfavorable (6.68e-8)" "unprognostic (3.74e-2)" "unprognostic (4.75e-2)" "unprognostic (1.31e-1)" "prognostic favorable (1.10e-4)" 1.3 3.1 6.9 21.8 1.5 18.5 1.2 1.8 1.5 2.3 1.0 2.4 3.7 1.3 0.2 1.3 2.2 8.8 1.0 1.3 4.9 1.6 1.6 4.7 47.3 4.2 8.4 1.3 1.4 0.7 0.9 0.5 3.7 1.4 2.3 0.2 3.3 1.6 0.6 0.7 18.3 0.6 3.0 31.5 7.5 1.7 14.0 20.9 1.5 0.2 29.5 17.1 1.3 4.6 16.7 2.6 0.1 0.1 0.0 0.0 12.2 0.1 0.0 0.5 0.0 32.4 35.5 122.7 29.2 0.0 0.0 27.2 0.0 0.4 0.3 42.1 1.1 0.1 3.1 0.3 0.6 0.4 0.0 0.0 0.0 0.2 0.0 0.8 23.1 13.3 50.1 0.0 0.0 0.3 4.7 0.0 44.9 20.6 0.1 5.9 0.1 30.7 11.4 91.4 0.3 1.5 0.1 0.2 0.1 17.7 0.2 2.5 15.4 0.2 11.8 0.1 0.1 12.3 0.1 108.0 0.0 0.0 0.2 0.5 0.0 0.0 7.7 0.0 7.2 5.4 4.4 5.2 0.9 6.2 2.9 5.3 0.2 5.5 0.0 31.4 3.5 2.9 6.9 1.5 1.8 1.5 1.3 4.9 4.2 8.4 3.7 3.0 14.0 4.6 0.5 0.0 0.0 0.7 34.9 0.0 0.3 0.3 0.6 0.6 0.3 0.4 2.0 0.0 0.3 1.8 0.0 0.0 47.2 0.7 0.0 4.6 0.2 0.4 0.3 0.6 0.0 0.8 2.1 5.3 0.0 1.6 14.3 0.7 5.7 8.6 0.4 0.2 1.5 0.0 1.6 0.3 0.0 2.4 1.8 0.4 0.3 5.4 3.6 49.6 1.0 0.1 28.8 1.0 0.6 24.9 0.0 0.0 26.7 0.3 0.0 0.1 1.0 0.2 0.0 0.3 0.9 1.5 0.2 0.0 0.3 0.0 28.6 4.5 0.4 8.1 CASR "FHH, GPRC2A, HHC, HHC1, NSHPT" ENSG00000036828 "Calcium sensing receptor" P41180 3 122183668-122291629 "Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Plasma proteins, Predicted membrane proteins, Transporters" "G-protein coupled receptor, Receptor, Transducer" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 29 "parathyroid gland: 654.4" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 25.6;Alveolar cells type 2: 20.2;Cholangiocytes: 27.1;Distal tubular cells: 13.7;Enteroendocrine cells: 11.5;Granulosa cells: 20.7;Respiratory ciliated cells: 15.3" "Cancer enriched" "Detected in some" 7 "pancreatic cancer: 5.5" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected" "Not detected" "HPA039686, HPA050335" Enhanced NA NA "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 40: Granulosa cells - Unknown function" "HPA039686: AB_10673536, HPA050335: AB_2681092" "unprognostic (1.97e-2)" "unprognostic (7.40e-2)" "unprognostic (8.20e-4)" "unprognostic (3.15e-1)" "unprognostic (8.55e-4)" "unprognostic (1.58e-1)" "unprognostic (7.32e-2)" "unprognostic (7.67e-2)" "unprognostic (1.62e-1)" "unprognostic (1.48e-1)" "unprognostic (1.91e-5)" "unprognostic (2.72e-1)" "unprognostic (2.26e-1)" "unprognostic (1.24e-2)" 0.1 0.1 1.5 0.1 1.0 0.8 0.0 1.7 1.6 0.0 0.3 0.1 0.8 0.0 0.1 0.0 0.1 4.2 0.0 1.0 0.6 22.4 0.2 0.0 0.2 0.6 1.1 0.5 9.6 654.4 0.2 0.0 0.8 0.1 0.2 1.5 0.1 0.0 0.1 0.2 0.5 0.0 0.2 0.1 2.8 0.2 1.7 0.1 0.7 0.0 0.2 0.3 0.0 1.7 0.1 0.2 0.1 0.2 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.2 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.3 0.2 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.1 0.3 0.0 0.1 0.1 0.1 0.3 0.1 0.1 0.1 0.1 0.1 0.8 0.3 0.1 0.1 0.2 0.1 0.0 0.3 0.2 0.0 0.2 0.2 0.3 0.2 0.0 0.3 0.2 0.1 0.1 0.1 0.2 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 1.5 1.0 1.7 1.6 1.0 0.6 0.6 1.1 0.8 0.2 1.7 1.7 0.0 25.6 20.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 27.1 5.6 3.7 0.0 0.0 0.0 0.0 13.7 4.3 0.5 0.0 0.0 0.5 11.5 0.0 0.3 0.2 0.0 1.6 0.0 0.0 1.3 20.7 0.0 0.1 0.1 0.0 0.1 0.6 0.0 1.0 0.0 1.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.1 0.4 0.0 0.0 0.0 0.2 15.3 1.0 0.0 0.0 1.5 0.0 0.5 0.0 0.0 0.0 0.9 0.8 0.0 0.0 CBL "c-Cbl, CBL2, RNF55" ENSG00000110395 "Cbl proto-oncogene" P22681 11 119206298-119313926 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 8.6" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004350, HPA027956" Enhanced Approved Cytosol NA NA 67000 "Cluster 1: Neutrophils - Mixed function" "Cluster 3: T-cells - Adaptive immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Cytosol "CAB004350: AB_2244054, HPA027956: AB_10601094" "unprognostic (2.52e-1)" "unprognostic (1.32e-3)" "unprognostic (1.60e-1)" "unprognostic (1.15e-1)" "unprognostic (1.50e-2)" "unprognostic (2.92e-1)" "unprognostic (4.10e-3)" "unprognostic (9.75e-2)" "unprognostic (1.72e-1)" "unprognostic (1.52e-1)" "unprognostic (1.03e-2)" "unprognostic (5.23e-2)" "unprognostic (5.21e-2)" "unprognostic (5.27e-2)" "unprognostic (1.52e-1)" "unprognostic (1.12e-1)" "unprognostic (5.85e-2)" 6.8 4.0 5.6 9.5 5.7 8.5 5.6 5.3 6.5 5.0 0.2 6.2 3.9 6.5 3.4 5.6 5.6 3.9 4.1 5.3 8.1 4.4 2.7 7.9 10.7 5.8 6.3 3.7 3.8 6.1 2.9 6.4 6.5 4.0 5.0 8.3 3.6 4.6 2.5 5.2 6.6 7.4 5.2 9.9 5.2 18.2 7.9 22.5 4.1 3.2 11.2 5.8 4.9 6.0 10.7 7.6 26.6 16.7 7.8 9.2 16.0 11.2 11.4 10.8 10.2 16.7 12.6 25.1 10.0 14.0 21.7 15.2 18.4 9.4 22.7 14.8 4.7 26.4 6.2 5.1 9.5 30.3 27.9 8.1 10.1 26.7 28.4 11.1 26.3 23.7 21.7 9.9 19.1 11.3 16.2 17.0 14.0 9.2 8.8 17.5 13.5 4.6 9.3 8.2 3.7 11.3 20.9 8.8 7.3 18.1 9.4 24.8 22.8 16.0 11.5 11.6 14.7 3.3 5.3 19.9 6.7 25.4 11.9 0.8 2.4 2.0 0.9 2.8 0.8 1.5 1.1 0.9 2.6 1.2 1.2 1.3 8.6 0.4 2.5 1.4 1.0 0.9 5.6 5.7 5.3 6.5 5.3 8.1 5.8 6.3 6.5 5.2 7.9 6.0 23.2 9.6 8.3 23.5 23.2 18.0 5.9 7.5 19.4 14.0 13.6 11.7 8.8 5.7 6.0 11.0 45.9 6.3 24.0 7.6 1.9 6.1 28.2 9.9 19.6 23.2 8.4 5.7 38.5 6.7 10.5 9.4 9.2 16.8 3.8 20.8 20.0 3.1 16.0 13.5 39.1 4.9 2.0 59.1 43.2 42.0 7.8 41.2 16.0 45.0 46.8 13.2 22.6 26.2 19.6 10.6 11.6 12.8 19.7 8.0 5.1 5.4 4.8 33.3 26.3 11.6 22.7 38.0 36.2 18.5 21.9 7.0 24.9 10.6 5.1 10.9 CCDC6 "D10S170, H4, PTC, TPC, TST1" ENSG00000108091 "Coiled-coil domain containing 6" Q16204 10 59788747-59906556 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019049, HPA019051" Enhanced Supported Cytosol No No 12000 "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 41: Macrophages - Immune response" Cytosol "HPA019049: AB_1846163, HPA019051: AB_1846164" "unprognostic (1.88e-2)" "unprognostic (1.72e-2)" "unprognostic (4.41e-2)" "unprognostic (1.25e-3)" "unprognostic (5.98e-3)" "prognostic favorable (5.48e-4)" "prognostic unfavorable (1.11e-4)" "unprognostic (7.39e-2)" "unprognostic (2.45e-1)" "unprognostic (2.28e-1)" "prognostic unfavorable (3.95e-4)" "unprognostic (4.08e-1)" "unprognostic (4.69e-2)" "unprognostic (2.23e-1)" "unprognostic (2.56e-1)" "unprognostic (9.95e-2)" "unprognostic (4.19e-2)" 11.9 12.2 21.1 13.9 23.4 16.8 22.4 10.2 20.0 23.4 8.5 23.5 22.8 24.9 16.7 34.1 25.3 16.7 10.0 24.9 21.4 21.2 12.1 17.3 21.4 12.4 15.8 15.7 25.2 17.9 11.5 13.2 17.4 19.4 19.8 18.3 29.0 14.3 17.3 28.6 16.2 30.8 11.9 14.7 18.6 11.4 20.8 12.1 18.3 12.2 21.6 17.3 23.1 12.6 42.9 38.0 18.7 41.9 27.8 41.6 37.9 20.6 27.2 20.2 23.7 74.4 81.8 36.5 30.2 34.6 11.7 61.7 37.7 37.5 30.0 55.1 18.7 29.8 29.1 45.5 33.5 34.5 26.9 30.3 48.7 33.7 81.8 28.3 30.2 20.4 22.6 22.7 26.6 57.6 14.5 19.8 29.9 40.1 25.6 19.2 30.5 23.0 33.9 36.2 19.0 16.6 26.1 107.8 23.1 24.1 68.7 18.4 31.1 18.8 33.9 29.3 34.9 12.0 14.9 16.3 29.6 64.6 11.9 0.0 2.0 0.0 1.0 2.3 1.1 4.3 1.5 1.3 5.0 4.9 1.3 1.0 0.1 0.8 1.3 1.3 1.4 1.0 21.1 23.4 10.2 20.0 24.9 21.4 12.4 15.8 17.4 11.9 20.8 12.6 24.0 99.3 25.9 45.1 41.6 95.0 51.7 25.3 70.0 15.1 51.2 38.7 16.5 28.6 46.3 25.8 41.7 37.8 31.4 42.6 29.4 50.2 27.6 105.2 54.6 22.4 27.0 25.7 83.2 65.3 18.8 27.8 39.8 134.5 29.1 45.2 17.2 20.1 23.1 16.8 58.4 38.9 30.5 40.7 35.3 80.6 24.5 36.4 16.0 32.8 23.0 11.5 13.4 55.3 34.2 50.2 25.0 19.5 26.4 52.2 47.1 48.4 28.1 49.8 19.7 31.4 27.0 2.3 22.4 92.3 80.1 27.0 24.3 32.5 46.3 46.1 CCND1 "BCL1, D11S287E, PRAD1, U21B31" ENSG00000110092 "Cyclin D1" P24385 11 69641156-69654474 "Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins" "Cell cycle, Cell division, DNA damage, Transcription, Transcription regulation" "Cyclin, Repressor" "Cancer-related genes, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 499.7;Ductal cells: 504.0;Pancreatic endocrine cells: 622.1;Urothelial cells: 412.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "myeloid DC: 1.1" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "U-266/70: 874.2;WM-115: 1239.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000024, HPA027802" Uncertain Supported Nucleoplasm Yes No "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 18: Non-specific - Mitochondria" "Cluster 17: WM-115 - Nervous system development" "Cluster 1: Pancreatic cells - Digestion" Nucleoplasm "CAB000024: AB_563678, HPA027802: AB_2672390" "unprognostic (4.90e-2)" "unprognostic (1.54e-1)" "unprognostic (7.62e-2)" "unprognostic (1.39e-2)" "unprognostic (2.18e-1)" "prognostic unfavorable (5.51e-4)" "unprognostic (1.38e-1)" "unprognostic (2.53e-2)" "unprognostic (9.46e-2)" "unprognostic (4.84e-3)" "prognostic unfavorable (1.96e-4)" "unprognostic (4.39e-2)" "unprognostic (2.61e-3)" "unprognostic (4.38e-3)" "unprognostic (1.16e-1)" "unprognostic (6.40e-3)" "unprognostic (2.57e-1)" 55.6 29.2 12.1 10.0 14.6 1.5 40.2 15.0 11.9 17.0 33.4 19.8 22.7 14.8 27.6 72.9 30.8 19.5 64.9 10.8 14.6 32.2 107.3 61.1 10.5 17.5 15.5 4.6 86.3 82.7 25.7 63.7 18.3 53.3 17.2 3.2 30.4 50.4 3.6 120.3 16.0 23.3 15.9 37.2 52.7 3.2 21.7 9.9 45.5 5.2 19.0 29.5 43.9 24.0 467.3 183.0 59.5 1.8 178.3 186.7 127.4 717.5 264.9 82.1 47.6 206.9 349.9 0.1 317.6 375.5 137.2 332.1 6.5 195.2 146.0 1.2 36.5 0.3 46.7 211.7 43.3 3.3 6.7 106.5 37.9 116.0 44.0 192.5 142.1 0.2 0.6 1.3 654.2 197.1 0.4 26.6 109.0 190.7 198.3 1.2 187.9 11.3 379.4 282.8 10.0 231.4 9.2 167.7 458.4 143.5 102.6 9.5 600.4 399.5 111.0 176.1 496.2 874.2 559.4 1.5 341.6 5.9 1239.0 0.2 0.0 0.0 0.2 0.0 0.0 0.9 0.1 0.0 1.1 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 12.1 14.6 15.0 11.9 10.8 14.6 17.5 15.5 18.3 15.9 21.7 24.0 84.6 182.7 115.6 0.3 8.3 202.5 234.7 499.7 133.1 2.3 163.4 140.0 80.0 92.9 271.6 125.0 2.1 10.9 2.4 44.8 31.3 504.0 0.4 104.2 23.5 141.0 56.5 2.5 0.5 142.6 1.2 67.6 127.4 199.5 29.1 0.0 98.2 165.2 75.0 0.0 2.2 42.6 75.3 18.8 61.9 2.0 4.1 23.6 51.6 17.8 2.4 79.1 0.0 49.8 0.3 622.1 118.0 57.6 0.5 262.0 19.4 57.1 85.9 3.1 131.5 13.0 184.8 0.5 23.4 292.3 351.1 2.5 8.8 3.4 82.2 412.6 CCND2 ENSG00000118971 "Cyclin D2" P30279 12 4269771-4305353 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cell cycle, Cell division" Cyclin "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 354.3;Granulosa cells: 438.5;Langerhans cells: 255.3;Plasma cells: 371.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "AF22: 152.4;HBEC3-KT: 136.6;HDLM-2: 238.8;Karpas-707: 287.9;RH-30: 202.7;RPMI-8226: 114.2" "HPA049138, HPA054196" Approved Enhanced Nucleoplasm Yes Yes "Cluster 16: MAIT-cells - Unknown function" "Cluster 46: Fibroblasts - ECM organization" "Cluster 2: Karpas-707 - Immune response" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "HPA049138: AB_2680650, HPA054196: AB_2682412" "unprognostic (2.98e-3)" "unprognostic (1.15e-1)" "unprognostic (7.21e-2)" "unprognostic (1.65e-2)" "unprognostic (1.70e-2)" "unprognostic (4.82e-2)" "unprognostic (4.94e-2)" "unprognostic (2.01e-3)" "unprognostic (3.16e-2)" "unprognostic (1.66e-2)" "prognostic favorable (2.52e-4)" "unprognostic (1.75e-1)" "unprognostic (1.25e-1)" "unprognostic (8.23e-2)" "unprognostic (4.52e-1)" "prognostic favorable (9.76e-5)" "unprognostic (7.06e-2)" 20.0 52.6 5.4 8.7 12.9 20.3 13.0 0.0 13.5 26.9 0.0 40.8 17.4 26.1 7.5 12.2 22.1 2.7 51.9 14.4 1.1 9.7 1.9 17.2 5.3 9.6 0.2 14.2 24.5 9.9 23.5 12.9 2.7 20.7 10.4 0.7 10.8 9.1 1.8 12.6 25.9 9.8 7.8 19.7 12.7 4.0 0.0 3.2 20.3 0.0 5.1 26.5 19.9 4.5 0.0 0.0 152.4 0.0 10.1 0.4 0.0 0.0 0.0 0.0 0.0 62.8 0.0 0.0 0.4 0.0 0.0 16.2 0.1 136.6 0.0 238.8 2.5 0.7 0.0 0.0 0.0 57.0 12.6 23.8 2.4 0.0 97.0 0.0 0.0 0.8 17.0 287.9 6.8 0.0 0.0 52.8 50.8 0.0 0.0 0.0 202.7 114.2 0.0 8.1 0.0 0.0 0.0 0.0 0.0 89.6 0.0 0.0 4.2 0.0 39.3 0.0 0.0 1.4 60.7 0.0 0.0 32.3 0.0 6.6 0.4 4.7 11.1 0.0 17.1 3.1 16.3 13.8 0.4 1.7 10.4 12.1 1.1 9.4 0.0 1.1 13.6 6.8 5.4 12.9 0.0 13.5 14.4 1.1 9.6 0.2 2.7 7.8 0.0 4.5 23.9 60.9 46.6 10.1 82.9 106.8 23.9 73.4 174.2 7.6 3.4 41.8 354.3 2.8 37.4 12.9 0.0 4.0 128.7 37.5 0.0 3.1 0.8 3.3 110.8 35.7 64.8 37.2 54.1 68.3 2.7 123.6 4.6 3.6 55.8 438.5 19.6 2.2 13.0 3.3 55.2 147.7 12.2 11.9 255.3 3.3 52.5 39.3 39.2 19.7 9.8 170.0 89.6 55.3 4.0 20.7 49.4 124.1 371.2 35.8 34.4 1.4 10.3 6.5 26.3 21.4 112.6 0.8 5.1 50.9 39.6 6.3 122.6 41.5 159.7 8.4 CCND3 ENSG00000112576 "Cyclin D3" P30281 6 41934934-42050357 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins" "Cell cycle, Cell division" Cyclin "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 256.6" "Cell type enhanced" "Detected in all" "NK-cells: 555.1;Syncytiotrophoblasts: 236.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MOLT-4: 696.3;REH: 651.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000116, HPA042871" Approved Supported Nucleoplasm NA Yes "Cluster 10: Basophils - Unknown function" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 51: Myeloid cells - Hemostasis" Nucleoplasm "CAB000116: , HPA042871: " "unprognostic (4.53e-2)" "unprognostic (4.45e-2)" "unprognostic (2.45e-1)" "unprognostic (4.40e-3)" "unprognostic (1.01e-1)" "unprognostic (9.80e-2)" "unprognostic (3.40e-2)" "unprognostic (5.25e-2)" "unprognostic (7.76e-2)" "unprognostic (3.45e-1)" "unprognostic (9.17e-2)" "unprognostic (6.39e-2)" "unprognostic (2.45e-3)" "unprognostic (9.12e-2)" "unprognostic (1.71e-1)" "prognostic favorable (8.08e-6)" "unprognostic (2.11e-1)" 74.3 137.6 84.8 63.1 84.6 220.2 64.8 80.0 94.5 36.9 78.4 45.6 40.6 35.4 15.3 39.6 43.2 34.4 68.1 86.2 88.6 42.4 22.1 102.5 143.3 87.4 82.5 36.0 31.6 23.7 33.3 55.4 84.0 50.4 27.0 10.3 50.4 25.6 18.2 52.3 78.5 28.6 79.7 170.4 66.1 11.1 86.4 256.6 58.7 32.5 83.6 45.4 44.3 80.8 67.7 242.2 24.6 54.8 43.7 88.6 286.1 77.1 43.7 77.7 57.1 45.9 29.7 288.9 127.8 51.9 68.9 40.5 65.8 93.4 39.2 49.2 43.4 458.8 106.6 37.3 94.9 75.9 385.2 84.7 59.8 76.0 27.9 23.5 96.6 188.3 236.7 27.2 111.6 92.0 696.3 354.6 10.9 202.8 51.5 651.8 96.3 32.2 179.1 44.9 83.8 21.8 65.8 83.3 38.6 30.6 51.5 288.4 162.9 86.2 47.9 74.7 88.1 17.9 15.2 458.5 50.4 157.6 53.3 1281.3 246.3 725.1 390.4 294.4 276.5 127.1 266.4 318.1 343.3 180.8 306.4 328.3 339.3 333.2 405.6 221.4 193.0 635.4 84.8 84.6 80.0 94.5 86.2 88.6 87.4 82.5 84.0 79.7 86.4 80.8 102.2 60.9 67.9 31.0 102.9 27.0 95.8 52.3 48.9 19.6 49.9 45.1 26.2 64.3 27.8 20.2 6.2 201.0 227.3 66.4 29.4 20.3 12.8 12.1 10.8 68.3 9.6 133.6 37.1 24.3 82.4 32.3 19.9 11.2 26.6 7.7 70.6 7.2 45.3 11.8 23.7 19.5 50.8 115.7 51.7 9.4 41.3 152.2 37.4 47.8 79.0 40.8 555.1 18.1 9.3 29.9 30.5 51.9 48.7 40.3 18.6 19.8 22.5 16.2 46.0 19.2 31.9 4.3 6.3 21.7 22.6 236.6 195.0 141.6 32.7 52.8 CCNE1 CCNE ENSG00000105173 "Cyclin E1" P24864 19 29811991-29824312 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins" "Cell cycle, Cell division" Cyclin "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 35.8;placenta: 30.8" "Cell type enriched" "Detected in many" 14 "Extravillous trophoblasts: 1756.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "BEWO: 293.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000308, CAB016682, HPA018169" Approved Enhanced Nucleoplasm Yes Yes "Cluster 43: B-cells - Humoral immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 28: BEWO - Transcription regulation" "Cluster 38: Extravillous trophoblasts - Unknown function" Nucleoplasm "CAB000308: , CAB016682: AB_1614564, HPA018169: AB_1847384" "unprognostic (2.90e-3)" "unprognostic (1.33e-2)" "unprognostic (1.47e-3)" "prognostic unfavorable (6.35e-6)" "unprognostic (5.78e-2)" "unprognostic (4.77e-2)" "prognostic unfavorable (3.89e-5)" "unprognostic (1.26e-3)" "unprognostic (3.14e-3)" "prognostic unfavorable (2.97e-4)" "unprognostic (3.29e-2)" "unprognostic (7.07e-2)" "unprognostic (1.11e-16)" "unprognostic (5.61e-2)" "unprognostic (1.92e-1)" "unprognostic (6.63e-2)" "unprognostic (1.46e-1)" 1.2 5.7 1.9 4.3 2.1 35.8 0.8 2.8 2.7 1.0 0.9 3.9 3.0 1.4 0.6 4.4 0.9 1.0 2.3 2.0 2.5 1.0 0.7 1.1 6.1 2.0 2.1 0.8 1.8 2.8 0.9 30.8 2.0 1.0 4.7 2.0 1.5 1.4 2.1 4.1 2.5 2.2 1.7 4.2 2.1 12.1 2.5 4.5 1.6 1.8 7.8 3.0 1.8 2.3 15.6 31.8 24.3 34.0 5.2 6.0 293.1 24.7 5.3 10.8 13.2 33.0 31.2 13.3 55.9 11.1 14.0 4.9 28.8 12.8 15.2 41.9 17.7 11.2 30.0 34.5 4.1 44.0 28.7 6.2 7.1 14.8 1.9 3.4 13.3 13.2 45.6 5.8 16.8 24.4 24.5 13.0 40.1 36.2 7.2 36.2 28.6 10.1 8.4 24.6 20.5 17.4 35.4 42.7 3.9 35.4 9.5 32.7 8.0 25.0 92.8 14.9 16.9 24.1 18.2 91.6 13.8 5.6 13.7 0.0 0.0 0.0 0.1 0.5 0.3 0.6 0.1 0.0 0.4 0.0 0.0 0.2 0.4 0.0 0.5 0.0 0.3 0.1 1.9 2.1 2.8 2.7 2.0 2.5 2.0 2.1 2.0 1.7 2.5 2.3 3.1 0.0 0.6 0.7 4.8 4.8 1.5 0.3 2.2 2.9 8.2 11.3 3.1 0.0 1.4 0.0 0.0 122.4 3.7 3.5 0.0 0.4 14.6 7.5 4.1 1.9 3.0 30.7 2.9 0.7 1756.5 6.0 5.6 20.1 0.0 4.6 1.4 0.2 43.4 3.3 5.1 3.3 0.0 1.0 2.5 3.6 1.2 4.2 1.8 0.0 0.2 1.7 0.0 2.5 1.3 1.4 2.2 2.2 18.4 2.2 1.0 0.4 0.1 1.1 6.6 4.1 3.4 25.0 17.6 8.5 6.0 115.7 4.5 6.9 4.9 3.5 CCNE2 CYCE2 ENSG00000175305 "Cyclin E2" O96020 8 94879770-94896678 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins" "Cell cycle, Cell division" Cyclin "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 37.0" "Cell type enhanced" "Detected in many" "Erythroid cells: 33.6;Oligodendrocytes: 34.5;Spermatocytes: 77.7;Spermatogonia: 26.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "T-reg: 5.2" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "Karpas-707: 101.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007825, CAB019374" Enhanced NA Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "CAB007825: AB_598148, CAB019374: " "unprognostic (1.80e-2)" "unprognostic (4.81e-2)" "unprognostic (7.49e-2)" "unprognostic (2.08e-2)" "unprognostic (2.36e-1)" "prognostic favorable (5.87e-4)" "unprognostic (8.37e-4)" "prognostic unfavorable (8.77e-4)" "unprognostic (3.18e-2)" "unprognostic (2.19e-2)" "unprognostic (3.64e-2)" "unprognostic (1.04e-2)" "unprognostic (7.01e-12)" "unprognostic (1.81e-2)" "unprognostic (1.50e-1)" "unprognostic (1.06e-2)" "unprognostic (3.03e-1)" 2.0 0.6 3.7 6.9 8.3 37.0 2.2 9.0 7.7 1.7 0.3 5.4 3.6 1.8 0.1 4.7 0.6 2.4 1.4 3.2 5.4 0.5 2.3 1.8 10.9 9.9 8.1 1.5 1.8 0.5 0.6 4.3 8.8 1.2 5.7 5.2 1.8 0.2 0.7 5.9 4.3 2.2 7.4 2.3 4.0 14.5 8.0 15.1 1.7 0.7 9.6 2.1 1.5 13.4 47.2 6.2 24.0 15.0 2.9 5.4 16.5 47.3 16.6 29.4 28.9 11.3 20.6 24.5 31.4 20.3 9.1 24.4 19.4 17.5 39.5 17.4 17.5 49.5 26.6 4.2 0.2 20.2 29.0 1.4 1.1 21.4 2.1 6.4 15.5 30.1 21.7 101.5 42.5 14.2 77.8 9.7 8.1 37.4 14.1 54.1 41.7 11.7 8.1 26.4 34.8 14.5 31.8 8.4 5.9 3.0 42.0 21.2 13.0 30.7 20.2 22.9 42.8 19.1 21.1 59.3 24.8 36.1 23.1 0.0 0.2 0.1 0.8 0.2 0.3 0.3 1.1 1.3 0.7 1.0 0.3 0.6 0.6 1.5 0.1 0.0 5.2 0.6 3.7 8.3 9.0 7.7 3.2 5.4 9.9 8.1 8.8 7.4 8.0 13.4 7.5 6.4 1.7 0.7 3.0 4.2 1.6 2.3 6.8 2.9 5.9 8.9 2.5 0.0 1.9 1.8 6.2 7.2 7.2 12.3 0.0 0.2 6.9 1.3 2.7 3.5 0.0 33.6 2.3 0.2 7.8 2.6 4.1 2.9 0.0 2.1 2.5 1.3 4.4 8.4 2.6 4.0 0.0 2.5 1.9 9.0 1.2 4.8 0.0 0.0 0.0 1.0 1.0 1.5 34.5 0.2 2.4 0.4 14.6 1.1 6.3 0.1 1.1 4.7 6.6 2.6 4.3 77.7 26.2 9.5 3.8 1.9 7.5 1.2 3.3 0.8 CD58 LFA3 ENSG00000116815 "CD58 molecule" P19256 1 116514534-116571039 "CD markers, Human disease related genes, Predicted membrane proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 144.1;Langerhans cells: 195.9;monocytes: 156.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Karpas-707: 135.9" "Low region specificity" "Detected in all" NA NA 6500000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "unprognostic (4.48e-3)" "unprognostic (3.20e-1)" "unprognostic (2.95e-2)" "unprognostic (4.03e-2)" "unprognostic (8.45e-2)" "unprognostic (1.95e-1)" "prognostic unfavorable (2.32e-6)" "unprognostic (9.84e-2)" "unprognostic (7.17e-2)" "unprognostic (4.72e-2)" "prognostic unfavorable (5.60e-4)" "unprognostic (2.82e-1)" "unprognostic (1.66e-2)" "unprognostic (1.86e-1)" "unprognostic (3.68e-2)" "unprognostic (2.17e-2)" "unprognostic (9.66e-2)" 22.7 10.1 7.5 24.8 8.2 57.9 18.0 8.0 10.5 13.6 10.2 22.3 28.8 12.8 16.1 25.4 12.5 21.5 34.3 7.4 8.8 20.0 12.7 29.1 19.0 9.2 8.4 5.4 7.0 11.9 6.7 16.9 9.4 9.3 29.0 2.0 20.7 10.3 8.7 20.0 29.6 16.9 8.6 24.7 19.0 6.8 9.0 9.7 13.2 10.8 20.3 29.7 19.7 10.2 36.4 20.5 14.7 14.2 24.4 40.7 9.3 18.2 31.3 31.0 30.2 9.2 68.4 6.5 33.2 31.8 36.2 45.9 11.0 31.4 32.7 35.8 12.8 32.8 36.9 12.9 15.5 45.8 43.5 11.2 41.4 25.9 23.0 66.4 17.9 8.5 29.4 135.9 19.2 64.7 19.8 34.6 7.3 53.7 22.3 38.4 49.9 8.6 63.0 29.4 4.9 10.3 36.6 26.9 108.3 15.1 14.0 16.8 33.8 22.3 17.1 30.3 47.2 20.6 39.4 4.6 51.3 22.4 113.2 133.7 50.6 89.8 37.3 51.0 26.1 20.7 32.7 31.7 43.9 9.5 4.2 18.2 165.7 18.5 64.4 5.0 64.3 37.4 7.5 8.2 8.0 10.5 7.4 8.8 9.2 8.4 9.4 8.6 9.0 10.2 52.3 9.6 31.5 10.1 23.8 18.2 20.0 144.1 15.4 0.2 9.9 7.1 28.9 30.0 63.2 14.7 0.0 4.4 40.2 48.1 3.9 39.4 3.2 16.0 5.1 38.1 10.8 46.7 3.2 27.6 1.6 31.9 13.3 19.0 53.0 3.4 28.2 7.7 58.7 1.7 1.5 18.7 34.6 33.0 195.9 3.6 10.5 72.2 12.4 45.0 156.1 3.3 34.0 4.5 1.4 46.7 41.7 11.7 24.3 16.9 46.3 26.5 41.3 0.7 32.9 27.9 23.6 11.3 2.4 28.2 27.8 1.9 44.7 9.6 18.6 42.6 CD79A "IGA, MB-1" ENSG00000105369 "CD79a molecule" P11912 19 41877279-41881372 "Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Adaptive immunity, Immunity" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "intestine: 152.3;lymphoid tissue: 545.2" "Group enriched" "Detected in some" 5 "B-cells: 1186.4;Plasma cells: 956.7" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Group enriched" "Detected in many" 38 "memory B-cell: 1273.8;naive B-cell: 1457.5" "Lineage enriched" "Detected in all" 40 "B-cells: 1457.5" "Group enriched" "Detected in some" 22 "Daudi: 1598.7;REH: 491.0;U-698: 1366.7" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB000019, HPA056444" Enhanced NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 16: Immune cells - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 57: B-cells - Immune response" "CAB000019: AB_2244527, HPA056444: " "prognostic favorable (8.45e-5)" "unprognostic (1.63e-3)" "unprognostic (4.13e-3)" "unprognostic (1.31e-3)" "unprognostic (2.02e-1)" "prognostic favorable (1.18e-5)" "unprognostic (1.23e-2)" "unprognostic (8.11e-3)" "unprognostic (9.41e-3)" "unprognostic (1.12e-2)" "unprognostic (2.53e-1)" "unprognostic (2.32e-1)" "prognostic unfavorable (2.15e-5)" "unprognostic (6.08e-2)" "unprognostic (3.39e-1)" "unprognostic (1.17e-1)" "unprognostic (1.46e-1)" 4.8 4.9 0.2 213.4 0.2 47.2 9.5 0.2 0.4 3.6 0.1 47.3 37.9 2.4 1.4 9.9 1.8 13.0 2.9 0.1 0.1 3.4 2.6 8.9 482.4 0.3 0.2 3.7 0.6 0.1 0.3 1.2 0.2 4.3 28.9 0.0 28.5 2.2 0.7 0.4 152.3 2.2 0.6 286.5 76.9 2.4 0.2 93.7 8.1 0.4 545.2 32.3 1.9 0.3 1.1 0.8 0.3 0.1 0.2 0.7 0.2 0.2 0.0 0.3 0.0 0.0 0.1 1598.7 1.2 0.0 0.1 0.0 0.2 0.2 0.0 0.5 0.7 2.7 0.0 1.7 0.2 2.6 1.8 0.5 0.6 0.2 0.0 0.0 0.0 8.0 3.1 0.4 0.1 1.1 1.6 9.9 0.1 0.1 0.4 491.0 0.8 2.5 0.1 0.0 0.5 0.5 0.8 0.5 1.3 0.0 0.0 4.8 1.6 0.1 4.3 0.3 0.8 7.8 1.4 1366.7 0.0 52.1 0.1 12.4 1.5 6.9 1.7 1.8 0.7 1273.8 4.1 2.1 2.5 1457.5 4.9 26.3 4.6 2.6 4.3 36.3 10.4 62.7 0.2 0.2 0.2 0.4 0.1 0.1 0.3 0.2 0.2 0.6 0.2 0.3 0.2 0.0 2.4 0.0 1186.4 1.8 0.5 0.5 0.6 0.0 0.7 0.9 0.2 1.5 0.2 0.0 0.0 0.2 18.2 0.7 0.0 1.8 0.2 0.1 0.3 0.5 0.0 10.5 0.0 25.6 0.4 2.2 6.6 0.2 0.0 0.4 2.2 1.0 0.8 0.0 0.0 0.4 0.0 4.1 1.4 0.0 0.3 5.3 138.7 0.0 6.3 0.0 15.5 0.0 0.0 181.7 0.4 0.4 956.7 0.3 0.2 0.9 0.0 0.0 0.0 0.2 0.7 0.3 0.6 0.9 1.4 0.1 23.5 0.2 5.3 0.2 CD79B "B29, IGB" ENSG00000007312 "CD79b molecule" P40259 17 63928740-63932336 "Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins" "Adaptive immunity, Immunity" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 4 "lymphoid tissue: 266.7" "Cell type enriched" "Detected in many" 4 "B-cells: 491.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Group enriched" "Detected in all" 4 "memory B-cell: 1132.1;naive B-cell: 1505.8" "Lineage enriched" "Detected in all" 5 "B-cells: 1505.8" "Cell line enhanced" "Detected in some" "Daudi: 1060.0;REH: 350.2;U-698: 1475.5" "Not detected" "Not detected" "Not detected" "Not detected" "HPA009178, CAB009751, HPA044107" Enhanced Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 16: Immune cells - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 57: B-cells - Immune response" "Plasma membrane" "Nucleoplasm, Cytosol" "CAB009751: AB_2275844, HPA009178: AB_1078483, HPA044107: " "unprognostic (3.90e-3)" "unprognostic (1.61e-3)" "unprognostic (5.21e-2)" "unprognostic (3.45e-3)" "unprognostic (4.22e-3)" "prognostic favorable (2.35e-4)" "unprognostic (1.82e-1)" "unprognostic (9.25e-3)" "unprognostic (3.89e-2)" "unprognostic (1.48e-1)" "unprognostic (1.04e-1)" "unprognostic (2.87e-2)" "unprognostic (2.50e-3)" "unprognostic (1.89e-1)" "unprognostic (1.44e-1)" "unprognostic (4.28e-2)" "unprognostic (2.75e-1)" 5.0 1.7 0.9 70.5 0.9 54.6 3.4 0.9 1.4 1.9 1.7 7.7 4.7 1.4 1.6 2.6 1.5 6.8 12.3 0.9 0.9 4.7 3.4 4.9 266.7 1.0 0.9 0.6 0.7 0.7 25.3 3.8 0.9 2.5 7.2 0.0 7.8 0.8 3.4 2.4 66.2 2.6 0.9 147.7 10.7 1.0 1.0 27.1 4.1 5.8 208.4 13.4 2.2 1.0 1.8 0.0 0.5 0.0 0.0 0.0 0.0 0.6 0.0 0.2 0.4 0.0 0.0 1060.0 7.8 0.0 0.4 0.3 0.0 0.0 0.0 0.5 0.0 2.7 0.0 0.4 0.6 0.6 0.5 0.0 0.0 0.1 0.0 0.0 1.2 0.4 1.2 56.9 0.0 0.0 0.6 23.0 0.3 0.0 0.0 350.2 0.9 4.4 0.0 0.0 0.5 0.0 1.7 0.0 0.7 5.8 0.0 16.2 1.7 0.1 3.7 0.3 0.6 51.3 54.4 1475.5 0.0 2.2 0.0 6.2 13.0 1.1 44.9 192.2 51.3 1132.1 57.1 30.1 47.0 1505.8 38.4 23.2 5.8 42.4 304.3 6.7 107.9 112.1 0.9 0.9 0.9 1.4 0.9 0.9 1.0 0.9 0.9 0.9 1.0 1.0 24.9 0.0 1.3 0.0 491.9 4.5 0.4 0.0 1.8 0.0 1.1 4.4 1.4 1.5 0.0 0.0 0.0 0.2 24.2 0.3 0.0 0.1 0.6 0.3 1.0 25.2 1.2 8.6 0.0 0.0 0.4 3.3 0.5 0.3 15.2 0.0 51.4 1.3 5.8 0.0 0.0 0.4 0.0 14.8 5.1 1.4 1.2 13.4 21.4 0.0 14.3 0.0 36.0 0.0 0.0 0.0 0.1 1.9 99.6 0.4 0.0 1.0 0.0 0.0 0.0 4.4 5.4 1.2 0.3 0.7 3.1 0.4 27.0 0.5 0.8 0.2 CDC73 "C1orf28, FIHP, HRPT1, HRPT2, parafibromin" ENSG00000134371 "Cell division cycle 73" Q6P1J9 1 193121983-193254815 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cell cycle, Transcription, Transcription regulation, Wnt signaling pathway" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002326, CAB016359, HPA069324" Supported Supported Nucleoplasm,Cytosol NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 89: Fibroblasts - ECM organization" "Cluster 43: THP-1 - Innate immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm Cytosol "CAB016359: AB_628102, HPA002326: , HPA069324: " "unprognostic (4.41e-2)" "unprognostic (6.22e-2)" "unprognostic (1.90e-2)" "unprognostic (5.30e-2)" "unprognostic (2.88e-3)" "unprognostic (3.53e-2)" "unprognostic (2.48e-3)" "unprognostic (5.74e-2)" "unprognostic (1.25e-1)" "unprognostic (1.40e-1)" "unprognostic (7.23e-3)" "unprognostic (2.17e-1)" "unprognostic (5.44e-3)" "unprognostic (3.47e-1)" "unprognostic (2.49e-1)" "unprognostic (6.73e-3)" "unprognostic (2.98e-3)" 11.3 9.5 5.8 7.3 6.9 8.9 10.7 6.1 7.3 11.1 4.5 10.2 5.6 10.3 8.5 8.4 7.2 5.9 9.6 4.6 8.1 10.4 9.2 7.9 7.5 6.9 7.2 11.5 6.4 12.9 5.6 9.4 7.9 15.1 9.0 10.1 7.7 9.7 12.2 7.0 7.7 10.3 7.9 8.6 7.0 5.9 6.5 10.6 13.1 5.6 7.9 9.7 8.5 8.3 9.3 2.4 16.6 11.5 18.3 18.9 4.9 6.7 16.1 19.5 16.4 6.5 12.3 10.5 5.2 20.4 8.8 10.7 16.8 14.9 24.7 6.1 4.1 7.3 8.1 7.2 16.1 16.0 11.6 13.7 16.0 14.9 17.7 20.6 17.8 11.1 8.1 14.2 28.8 3.5 13.9 9.2 11.9 21.9 2.5 10.6 7.0 15.0 26.6 8.2 3.9 12.3 8.6 26.8 22.3 21.0 18.3 14.0 9.2 19.3 2.2 16.4 12.6 12.2 7.2 7.6 11.9 10.2 30.1 2.2 0.5 0.7 0.8 1.0 1.2 0.9 1.1 0.6 0.6 0.5 1.4 1.2 0.3 1.3 0.8 1.0 0.9 0.4 5.8 6.9 6.1 7.3 4.6 8.1 6.9 7.2 7.9 7.9 6.5 8.3 44.5 35.3 25.4 54.5 44.9 37.2 35.6 38.4 36.5 30.4 24.4 21.8 44.5 25.8 27.2 33.1 35.5 25.0 48.0 18.2 33.2 37.5 19.7 24.6 39.6 38.0 11.4 40.8 71.9 32.2 42.0 39.1 28.1 30.8 41.1 17.6 25.4 17.2 31.6 21.9 76.4 15.8 34.6 27.4 49.1 8.5 33.5 38.3 28.4 54.4 46.0 35.2 41.2 78.4 112.3 35.5 16.9 36.1 50.3 34.9 19.2 36.3 20.6 36.7 26.3 49.0 48.3 55.6 33.0 36.8 34.9 38.0 44.4 30.3 18.6 27.9 CDH1 "CD324, UVO, uvomorulin" ENSG00000039068 "Cadherin 1" P12830 16 68737292-68835537 "Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins" "Cell adhesion" "Cancer-related genes, Disease variant, Ectodermal dysplasia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "parathyroid gland: 197.8" "Cell type enhanced" "Detected in many" "Distal enterocytes: 451.6;Glandular and luminal cells: 321.0;Pancreatic endocrine cells: 264.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 13 "myeloid DC: 1.7;plasmacytoid DC: 4.7" "Lineage enriched" "Detected in single" 19 "dendritic cells: 4.7" "Cell line enhanced" "Detected in many" "BEWO: 683.3;CACO-2: 241.9;CAPAN-2: 328.1;HaCaT: 318.7;hTCEpi: 217.2;MCF7: 199.6;OE19: 207.2;RT4: 237.7;T-47d: 209.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB000087, HPA004812, CAB028364, CAB072855, CAB072856, CAB072857" Enhanced Supported "Golgi apparatus,Plasma membrane,Cell Junctions" NA NA 78000000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 28: BEWO - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane, Cell Junctions" "Golgi apparatus" "CAB000087: AB_2533003, CAB028364: AB_2076812, CAB072855: AB_2665698, CAB072856: AB_2665699, CAB072857: AB_2665700, HPA004812: AB_1078369" "unprognostic (3.95e-2)" "unprognostic (1.91e-1)" "unprognostic (1.12e-3)" "unprognostic (1.13e-1)" "unprognostic (1.42e-1)" "unprognostic (2.78e-1)" "unprognostic (5.04e-3)" "unprognostic (1.63e-1)" "unprognostic (5.47e-2)" "unprognostic (2.85e-1)" "unprognostic (1.19e-2)" "unprognostic (3.61e-1)" "prognostic favorable (2.06e-4)" "unprognostic (1.21e-1)" "unprognostic (2.62e-1)" "unprognostic (2.51e-1)" "unprognostic (5.92e-2)" 1.0 0.2 1.5 16.1 2.0 6.5 64.2 0.6 1.9 30.0 19.3 127.5 133.9 9.6 39.5 76.9 51.5 45.7 0.3 1.5 1.3 39.8 97.2 36.8 5.6 2.0 1.3 1.3 84.0 197.8 8.0 60.9 1.3 91.7 131.0 0.1 71.9 41.7 0.3 107.7 127.9 5.1 2.1 10.3 104.2 0.4 2.3 20.1 162.7 0.1 29.0 58.2 38.1 2.7 147.0 14.8 0.0 0.5 0.0 0.0 683.3 0.0 0.0 0.0 0.0 241.9 328.1 0.0 3.1 0.0 0.0 318.7 0.0 156.3 0.0 28.6 3.5 0.1 0.7 48.0 0.0 0.0 0.6 0.0 217.2 0.1 0.6 0.0 0.0 0.0 0.0 0.1 0.0 199.6 0.2 1.0 5.5 207.2 0.8 0.1 0.1 2.1 53.9 237.7 8.5 0.8 1.4 0.2 58.9 91.8 209.2 0.4 0.0 0.4 0.9 0.7 0.6 0.1 0.3 0.2 0.2 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 1.7 0.0 0.0 0.0 0.0 0.2 0.0 4.7 0.0 0.1 1.5 2.0 0.6 1.9 1.5 1.3 2.0 1.3 1.3 2.1 2.3 2.7 0.6 131.4 69.8 0.7 1.4 94.1 130.3 73.8 45.5 0.0 137.6 83.6 0.9 128.7 95.3 163.7 0.0 117.6 2.5 451.6 1.9 129.1 0.1 159.3 29.2 4.4 86.7 9.0 0.7 113.5 29.6 3.4 132.0 321.0 1.3 2.8 0.4 63.4 11.7 0.0 1.4 208.3 75.3 1.2 13.4 0.0 0.3 3.2 53.4 1.0 3.3 0.0 0.0 0.5 32.1 264.6 204.6 0.4 2.2 195.5 159.5 4.5 118.2 0.0 0.0 0.0 7.1 0.1 0.1 100.6 131.6 50.5 2.7 0.0 154.8 251.5 CDH11 "CAD11, OB" ENSG00000140937 "Cadherin 11" P55287 16 64943753-65126112 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion" "Cancer-related genes, Deafness, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "ovary: 178.2;placenta: 122.2" "Cell type enhanced" "Detected in many" "Astrocytes: 93.0;Endometrial stromal cells: 125.0;Excitatory neurons: 122.2;Fibroblasts: 102.2;Microglial cells: 145.2;Oligodendrocyte precursor cells: 158.3;Oligodendrocytes: 106.3;Theca cells: 160.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ: 246.5;BJ hTERT+: 139.3;fHDF/TERT166: 332.3;HSkMC: 217.4;PC-3: 291.2;U-2197: 194.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB013072 Enhanced NA Yes 4800000 "Cluster 89: Fibroblasts - ECM organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 33: Fibroblasts - ECM organization" "CAB013072: AB_2533068" "unprognostic (1.77e-1)" "unprognostic (1.51e-1)" "unprognostic (1.50e-1)" "unprognostic (6.93e-2)" "unprognostic (6.00e-2)" "unprognostic (1.02e-1)" "unprognostic (6.96e-2)" "unprognostic (1.28e-1)" "unprognostic (2.09e-1)" "unprognostic (2.30e-2)" "unprognostic (3.74e-2)" "unprognostic (6.75e-2)" "prognostic unfavorable (2.48e-9)" "unprognostic (1.43e-3)" "unprognostic (3.20e-2)" "unprognostic (1.26e-1)" "unprognostic (5.07e-3)" 15.1 8.6 12.4 25.7 27.9 0.3 10.7 10.8 15.8 57.7 13.8 11.4 7.0 52.8 9.5 7.4 12.5 58.6 10.2 19.2 21.4 10.2 1.8 45.6 17.5 17.1 24.1 178.2 3.4 2.6 10.4 122.2 17.3 20.0 12.2 14.0 12.7 24.3 2.6 10.9 8.9 54.3 21.1 89.3 11.8 8.0 19.3 3.7 8.1 3.1 13.0 47.6 13.6 21.4 0.2 0.0 51.4 0.1 35.7 77.5 0.3 246.5 139.3 61.0 34.5 4.6 0.2 0.0 0.0 332.3 0.0 0.1 0.1 1.7 43.4 0.0 2.1 0.0 1.4 0.0 29.7 0.0 14.4 217.4 0.1 74.7 14.9 0.0 17.4 0.0 0.0 0.0 33.1 0.3 0.1 0.3 19.2 37.4 291.2 0.8 38.0 0.0 0.0 0.0 0.8 36.0 0.1 0.3 0.2 64.5 0.3 0.1 0.0 124.4 17.2 194.0 70.1 0.0 0.0 0.1 21.5 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.4 27.9 10.8 15.8 19.2 21.4 17.1 24.1 17.3 21.1 19.3 21.4 11.4 3.2 0.0 93.0 0.1 3.8 1.0 7.9 0.0 19.9 1.0 7.4 3.1 1.5 3.3 0.0 0.0 2.6 0.2 0.1 0.0 0.1 2.7 3.9 125.0 17.8 0.0 2.7 122.2 0.0 2.3 102.2 0.5 2.7 0.0 60.0 68.9 0.0 4.7 0.0 67.6 0.6 0.0 0.6 6.9 4.2 52.5 0.9 5.4 145.2 0.0 41.9 0.0 158.3 106.3 0.8 0.0 77.5 0.0 1.6 0.0 1.4 0.4 2.1 26.3 12.8 38.0 1.7 1.1 0.5 3.1 5.6 1.1 160.2 0.3 0.5 CDK4 PSK-J3 ENSG00000135446 "Cyclin dependent kinase 4" P11802 12 57747727-57756013 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Cancer enriched" "Detected in all" 5 "glioma: 175.8" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Group enriched" "Detected in all" 10 "HBEC3-KT: 2594.8;LHCN-M2: 2819.4;RH-30: 8902.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006024, CAB013116, CAB069405" Supported Supported "Nucleoplasm,Nuclear membrane,Nucleoli,Cytosol" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 89: Fibroblasts - ECM organization" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 39: Non-specific - Basic cellular processes" Cytosol "Nucleoplasm, Nuclear membrane, Nucleoli" "CAB013116: AB_2536376, CAB069405: AB_1613464, HPA006024: AB_2667497" "unprognostic (8.88e-2)" "unprognostic (2.53e-1)" "unprognostic (5.27e-2)" "unprognostic (9.01e-2)" "unprognostic (2.21e-1)" "unprognostic (1.10e-1)" "prognostic unfavorable (2.09e-7)" "unprognostic (7.39e-2)" "unprognostic (3.23e-3)" "unprognostic (2.93e-2)" "unprognostic (3.19e-2)" "unprognostic (9.10e-2)" "prognostic unfavorable (3.15e-5)" "unprognostic (3.32e-1)" "unprognostic (1.67e-1)" "unprognostic (3.64e-1)" "unprognostic (1.57e-2)" 69.7 87.8 35.0 52.8 37.9 72.0 76.6 37.7 36.9 84.3 35.9 62.6 40.2 97.4 64.2 57.2 69.4 57.1 58.9 33.6 37.1 58.5 51.5 58.0 66.8 37.1 36.9 97.3 70.9 63.5 67.7 52.4 36.8 52.7 63.3 14.5 54.4 54.1 48.2 58.9 47.2 80.4 37.3 51.5 54.8 24.1 37.3 67.6 66.0 52.7 70.6 71.6 60.7 37.6 207.1 235.7 295.7 268.0 253.7 220.7 210.4 116.1 347.9 468.5 385.7 338.2 189.1 297.4 200.2 173.6 293.2 158.0 396.3 2594.8 354.9 150.9 209.0 275.4 149.5 237.9 297.0 309.7 182.5 221.5 180.9 294.2 326.7 326.4 304.8 280.0 301.3 242.7 2819.4 304.9 296.7 256.5 347.0 208.0 249.8 267.3 8902.5 272.1 147.2 320.6 271.2 251.7 205.3 150.2 310.0 195.1 202.8 380.7 146.1 233.6 217.0 265.8 233.1 122.2 206.1 450.8 214.1 291.3 286.9 9.5 46.5 10.3 79.6 65.6 81.8 93.5 70.0 72.5 66.7 90.0 93.0 84.4 4.4 56.6 41.9 84.9 57.0 73.6 35.0 37.9 37.7 36.9 33.6 37.1 37.1 36.9 36.8 37.3 37.3 37.6 47.1 22.4 30.8 7.8 40.0 89.7 78.6 83.4 74.0 15.9 67.2 82.2 0.7 51.5 35.3 47.8 10.4 82.9 26.1 15.9 70.5 93.1 13.5 14.9 77.7 50.8 45.6 98.0 5.2 62.5 134.5 79.4 28.5 22.6 69.1 60.2 39.7 35.8 132.9 18.5 6.7 42.2 40.7 25.1 44.1 8.0 64.0 31.2 53.4 6.5 41.9 51.4 29.9 5.5 8.0 48.3 18.9 63.2 57.8 113.9 14.0 80.9 7.4 17.9 32.9 62.1 61.9 32.1 48.3 74.5 86.1 46.8 32.3 78.8 78.7 49.4 CDKN1A "CAP20, CDKN1, CIP1, P21, p21CIP1, p21Cip1/Waf1, SDI1, WAF1" ENSG00000124762 "Cyclin dependent kinase inhibitor 1A" P38936 6 36676460-36687337 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins" "Cell cycle" "Protein kinase inhibitor" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "non-classical monocyte: 74.5" "Group enriched" "Detected in many" 9 "B-cells: 20.7;dendritic cells: 21.5;monocytes: 74.5" "Cell line enhanced" "Detected in many" "HHSteC: 798.5;HSkMC: 586.5;hTCEpi: 775.8;LHCN-M2: 604.2" "Region enhanced" "Detected in all" "olfactory bulb: 76.0" "Low region specificity" "Detected in all" "CAB000064, HPA005946, CAB069401" Supported Supported "Nucleoplasm,Nuclear bodies" NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 89: Fibroblasts - ECM organization" "Cluster 30: Epithelial cell lines - Translation" "Cluster 7: Non-specific - Mitochondria" "Nucleoplasm, Nuclear bodies" "CAB000064: , CAB069401: AB_1620493, HPA005946: AB_2667477" "unprognostic (7.99e-3)" "unprognostic (4.01e-2)" "unprognostic (1.58e-1)" "prognostic favorable (3.14e-5)" "unprognostic (1.57e-2)" "unprognostic (2.19e-2)" "unprognostic (1.39e-2)" "prognostic unfavorable (7.05e-4)" "unprognostic (1.30e-1)" "unprognostic (7.27e-2)" "unprognostic (2.79e-2)" "unprognostic (7.55e-3)" "prognostic favorable (4.95e-5)" "unprognostic (8.32e-2)" "unprognostic (6.52e-2)" "unprognostic (1.12e-1)" "unprognostic (3.21e-2)" 322.1 98.1 47.0 62.1 48.1 72.7 144.2 47.3 60.9 123.3 85.9 119.0 115.2 74.4 41.0 203.2 213.9 132.6 170.6 47.2 49.5 149.9 173.4 182.2 17.3 63.7 54.6 184.9 130.5 70.1 104.4 44.7 53.4 91.4 108.2 29.2 79.1 29.4 241.6 224.4 130.0 114.3 55.0 34.4 121.3 47.0 50.3 59.7 77.5 26.9 21.8 212.7 142.3 53.6 27.0 108.1 80.1 2.0 273.3 490.3 149.5 435.6 344.8 52.3 203.7 9.6 25.3 18.3 15.5 267.9 48.0 60.2 3.7 477.7 82.4 36.2 22.0 3.0 85.8 137.0 798.5 0.5 127.7 586.5 775.8 476.2 147.1 309.3 275.3 1.4 5.1 120.8 604.2 57.4 3.9 11.3 10.2 112.8 15.5 54.4 67.1 31.9 91.2 201.5 36.7 35.6 101.3 8.4 21.3 185.2 32.7 111.2 155.8 91.5 86.9 6.2 36.4 202.0 42.9 54.5 118.7 9.9 261.0 0.0 22.8 0.5 0.5 52.2 0.8 20.7 1.1 0.6 20.0 16.2 0.3 0.4 4.2 0.7 74.5 21.5 2.9 34.2 47.0 48.1 47.3 60.9 47.2 49.5 63.7 54.6 53.4 55.0 50.3 53.6 571.2 83.3 45.1 1.0 126.9 440.5 340.1 293.1 512.8 0.8 203.9 187.6 151.6 41.5 214.4 68.0 0.0 42.1 56.4 505.3 46.9 217.6 0.9 227.9 57.3 327.1 175.5 5.7 0.5 264.7 52.8 302.4 150.9 199.2 104.4 20.4 71.7 68.9 72.9 0.0 0.4 197.1 156.6 62.0 556.0 3.9 34.5 277.6 218.7 5.6 280.6 58.4 2.1 0.0 0.5 429.9 466.1 16.6 376.4 201.7 383.2 17.2 215.1 3.1 26.3 303.6 471.6 1.2 1.7 620.9 672.0 155.3 106.0 10.7 75.8 478.0 CDKN1B "KIP1, P27KIP1" ENSG00000111276 "Cyclin dependent kinase inhibitor 1B" P46527 12 12715058-12722369 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cell cycle" "Protein kinase inhibitor" "Cancer-related genes, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Muller glia cells: 182.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003691, CAB021888, HPA059086" Approved Supported Nucleoplasm,Vesicles NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 2: Karpas-707 - Immune response" "Cluster 24: Non-specific - Transcription regulation" Nucleoplasm Vesicles "CAB003691: AB_425362, CAB021888: , HPA059086: AB_2683900" "unprognostic (5.67e-2)" "unprognostic (9.76e-2)" "prognostic favorable (5.15e-4)" "unprognostic (6.90e-3)" "unprognostic (5.84e-3)" "unprognostic (1.03e-2)" "prognostic unfavorable (3.25e-4)" "unprognostic (4.04e-2)" "unprognostic (1.11e-1)" "unprognostic (2.85e-3)" "unprognostic (9.23e-3)" "unprognostic (2.96e-1)" "prognostic unfavorable (8.39e-4)" "unprognostic (1.23e-1)" "unprognostic (8.68e-2)" "unprognostic (2.88e-1)" "unprognostic (1.15e-1)" 53.4 44.7 53.6 40.1 70.6 68.1 50.2 73.4 81.3 55.3 43.1 43.9 44.5 41.0 24.5 29.1 47.3 24.6 32.9 47.9 58.9 30.2 35.2 38.9 55.3 58.6 58.3 66.1 23.9 34.4 24.4 41.0 61.2 35.9 32.5 55.3 36.3 33.4 81.4 45.4 40.7 24.8 55.1 55.1 30.0 25.8 58.3 71.8 33.7 63.4 39.9 32.0 44.5 91.2 37.1 16.6 94.5 16.6 32.0 18.0 46.1 31.5 53.8 46.0 56.4 47.7 40.4 0.3 12.5 19.6 16.6 34.2 44.9 16.7 41.1 62.4 31.5 28.8 46.5 53.2 42.5 24.5 18.6 19.8 35.3 15.2 44.0 107.8 27.8 54.5 31.5 101.6 16.6 45.9 32.7 35.3 38.0 32.1 16.8 25.2 30.9 63.1 22.5 38.6 35.6 58.4 48.9 34.8 65.8 33.7 18.6 54.6 19.1 22.6 34.9 20.7 33.3 86.1 59.4 33.2 28.2 36.6 22.5 6.2 3.8 8.6 5.9 3.5 6.1 6.8 7.7 7.2 3.6 5.0 8.0 6.1 20.9 7.3 5.5 3.9 12.3 4.0 53.6 70.6 73.4 81.3 47.9 58.9 58.6 58.3 61.2 55.1 58.3 91.2 64.2 44.8 29.3 6.2 126.2 52.6 20.7 21.0 115.5 45.6 39.5 30.1 39.1 21.5 27.1 9.2 27.1 42.9 92.5 32.3 15.6 10.8 70.0 31.2 35.8 51.1 45.7 70.5 8.1 9.3 47.6 39.3 25.5 34.3 31.0 21.3 47.2 30.7 26.8 10.1 13.4 41.4 24.4 55.3 66.0 67.7 55.9 65.1 74.7 23.4 31.6 182.9 60.8 6.0 29.5 10.1 21.3 26.7 121.2 30.3 33.4 16.9 36.4 29.4 92.1 20.2 53.5 7.7 10.8 102.3 52.6 39.0 166.1 20.9 41.9 22.7 CDKN1C "BWCR, BWS, KIP2, P57" ENSG00000129757 "Cyclin dependent kinase inhibitor 1C" P49918 11 2883213-2885775 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cell cycle" "Protein kinase inhibitor" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "ovary: 206.4" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 575.3;Extravillous trophoblasts: 1531.7;Syncytiotrophoblasts: 2241.2;Theca cells: 781.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 10 "intermediate monocyte: 155.1;non-classical monocyte: 376.4" "Lineage enriched" "Detected in many" 14 "monocytes: 376.4" "Cell line enhanced" "Detected in many" "EFO-21: 12.0;HeLa: 12.8;RPMI-8226: 18.7;SH-SY5Y: 33.0;SiHa: 25.2;SK-MEL-30: 15.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002924 Enhanced Approved "Nucleoplasm,Nuclear bodies,Cytosol" NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 89: Fibroblasts - ECM organization" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" "Nucleoplasm, Nuclear bodies" Cytosol "HPA002924: AB_1079548" "unprognostic (5.49e-3)" "unprognostic (2.62e-1)" "unprognostic (9.82e-3)" "unprognostic (5.79e-3)" "unprognostic (4.15e-1)" "unprognostic (2.84e-2)" "unprognostic (1.95e-2)" "unprognostic (1.85e-1)" "unprognostic (3.13e-1)" "unprognostic (3.15e-1)" "unprognostic (2.95e-1)" "unprognostic (3.39e-2)" "unprognostic (2.15e-1)" "unprognostic (3.31e-2)" "unprognostic (8.53e-2)" "unprognostic (1.93e-1)" "unprognostic (2.94e-1)" 127.4 182.9 8.2 3.3 38.0 1.7 92.5 43.3 18.7 73.7 6.5 48.1 1.4 70.6 0.2 29.9 70.7 0.8 82.6 11.7 18.8 149.5 8.3 34.5 0.2 55.1 33.5 206.4 28.5 0.2 27.8 28.1 45.0 33.1 0.2 0.5 21.7 1.5 60.3 26.6 25.0 0.4 31.8 20.6 54.1 8.6 34.3 0.2 17.0 0.9 0.4 75.0 49.4 95.3 0.1 0.1 1.6 0.0 0.4 0.5 1.8 0.3 0.6 0.3 0.0 3.3 0.4 0.0 12.0 0.2 0.1 0.5 0.3 0.3 0.1 5.6 1.2 0.1 12.8 0.0 3.3 0.0 1.4 2.4 1.6 0.0 0.2 0.1 0.3 0.1 2.7 0.8 0.5 0.1 0.0 6.0 10.6 0.5 4.0 2.2 0.0 18.7 0.7 0.0 3.5 33.0 25.2 0.3 15.2 0.9 0.2 2.8 0.4 0.0 2.2 0.0 0.1 7.3 0.0 0.1 0.0 1.8 6.8 9.1 1.2 0.9 0.4 155.1 1.8 0.0 0.4 0.6 26.9 0.3 1.0 0.3 2.2 0.0 376.4 0.2 0.7 14.7 8.2 38.0 43.3 18.7 11.7 18.8 55.1 33.5 45.0 31.8 34.3 95.3 357.3 3.2 5.8 1.0 11.6 10.7 81.7 4.9 30.7 11.9 81.0 150.5 45.3 61.5 10.8 31.3 6.2 575.3 46.9 20.3 15.6 9.8 176.5 38.8 101.5 100.8 106.5 0.8 0.6 0.6 1531.7 141.0 17.9 56.2 0.0 31.2 74.6 4.0 91.0 8.4 1.2 25.0 12.2 23.5 23.2 276.4 74.3 54.9 35.6 4.7 14.1 68.3 0.0 3.5 65.7 4.3 4.2 44.4 12.9 64.6 4.0 78.5 7.5 27.4 32.9 238.3 71.4 2.1 3.5 17.3 11.8 2241.2 25.1 781.8 15.2 71.8 CDKN2A "ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, p16INK4a, p19, p19Arf" ENSG00000147889 "Cyclin dependent kinase inhibitor 2A" "P42771, Q8N726" 9 21967752-21995301 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle, rRNA processing, Transcription, Transcription regulation, Ubl conjugation pathway" DNA-binding "Cancer-related genes, Disease variant, Li-Fraumeni syndrome, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 31.7;pituitary gland: 33.7" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 170.1;Club cells: 145.9;Early spermatids: 227.5;Late spermatids: 447.9;Pancreatic endocrine cells: 417.7;Respiratory ciliated cells: 221.9" "Cancer enhanced" "Detected in all" "cervical cancer: 49.9;ovarian cancer: 57.6" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "T-reg: 37.4" "Group enriched" "Detected in many" 6 "B-cells: 15.6;T-cells: 37.4" "Cell line enhanced" "Detected in many" "CAPAN-2: 289.2;HEK 293: 389.7;HeLa: 311.1;SK-MEL-30: 318.7" "Low region specificity" "Detected in some" "CAB000093, CAB000445, CAB018232, HPA047838" Enhanced Supported Nucleoli NA NA 18000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 16: Pancreatic endocrine cells - Mixed function" Nucleoli "CAB000093: AB_442119, CAB000445: , CAB018232: AB_785018, HPA047838: AB_2680174" "unprognostic (3.41e-2)" "unprognostic (4.51e-2)" "unprognostic (3.00e-3)" "prognostic unfavorable (1.82e-7)" "unprognostic (5.22e-2)" "prognostic favorable (5.19e-4)" "prognostic unfavorable (2.17e-4)" "unprognostic (1.25e-2)" "unprognostic (1.05e-1)" "unprognostic (1.04e-1)" "unprognostic (1.71e-1)" "unprognostic (1.56e-2)" "prognostic unfavorable (5.76e-7)" "unprognostic (9.41e-2)" "unprognostic (1.22e-2)" "unprognostic (3.05e-2)" "unprognostic (3.55e-1)" 3.7 10.1 7.4 1.7 8.3 1.3 3.1 5.9 8.5 1.1 31.7 1.9 0.8 0.7 1.0 7.4 2.2 0.5 0.7 6.7 6.4 0.5 0.7 2.3 2.1 7.4 5.8 0.8 1.5 2.1 33.7 2.6 7.2 2.1 0.7 0.1 1.6 1.6 0.6 0.9 3.6 0.3 6.2 5.5 3.9 14.8 8.0 2.1 1.3 0.0 2.5 2.4 2.3 9.2 11.8 0.0 1.7 82.2 0.8 0.9 39.1 15.9 0.0 111.7 196.0 19.1 289.2 47.1 167.7 9.5 0.0 36.0 34.3 211.0 91.4 212.2 389.7 0.1 311.1 13.6 8.8 22.4 17.3 21.2 0.0 112.2 61.9 236.3 11.7 0.0 0.1 188.4 105.7 0.8 1.9 0.0 2.6 24.2 185.9 0.2 80.2 166.3 23.4 0.0 195.2 14.0 219.9 36.6 318.7 9.4 42.8 0.7 39.5 0.9 2.6 0.3 0.5 84.7 49.6 177.8 0.2 62.9 1.0 1.5 2.1 0.3 9.9 1.3 14.1 11.1 11.4 17.6 0.3 15.6 0.6 6.7 0.5 0.8 4.2 0.0 37.4 3.6 7.4 8.3 5.9 8.5 6.7 6.4 7.4 5.8 7.2 6.2 8.0 9.2 1.6 0.0 0.0 1.0 11.5 1.8 2.3 170.1 0.0 0.6 6.1 10.4 4.2 0.0 145.9 11.0 0.0 27.9 6.2 8.1 0.0 29.7 227.5 36.4 6.7 2.6 70.9 0.0 1.2 26.4 43.8 7.7 0.0 6.2 4.5 4.6 1.4 0.3 7.6 0.0 3.5 6.3 122.1 10.5 4.2 447.9 3.1 2.9 8.8 7.5 16.2 0.9 5.2 4.5 6.6 417.7 12.1 1.9 38.7 35.4 32.8 0.0 221.9 0.1 0.0 1.1 20.8 7.2 6.2 7.2 0.4 9.2 12.7 11.0 3.8 54.4 CDKN2B "CDK4I, INK4B, MTS2, P15, p15INK4b, TP15" ENSG00000147883 "Cyclin dependent kinase inhibitor 2B" P42772 9 22002903-22009305 "Human disease related genes, Predicted intracellular proteins" "Cell cycle" "Tumor suppressor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 36.2;intestine: 30.9" "Cell type enhanced" "Detected in many" "Distal enterocytes: 240.7;Pancreatic endocrine cells: 164.5;Proximal enterocytes: 139.0;Squamous epithelial cells: 142.0;Urothelial cells: 241.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 10 "classical monocyte: 3.3;intermediate monocyte: 3.3;non-classical monocyte: 9.0" "Lineage enriched" "Detected in single" 17 "monocytes: 9.0" "Cell line enhanced" "Detected in many" "ASC TERT1: 38.1;HaCaT: 35.0;HeLa: 33.9;hTERT-RPE1: 60.1;SiHa: 48.0;SK-MEL-30: 35.7" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" "CAB000349, HPA052838, HPA063327" Uncertain Approved Nucleoplasm NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 20: HeLa - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "CAB000349: , HPA052838: , HPA063327: AB_2684987" "unprognostic (2.30e-1)" "unprognostic (9.23e-2)" "unprognostic (2.19e-1)" "prognostic unfavorable (4.47e-6)" "unprognostic (2.10e-1)" "unprognostic (7.40e-2)" "prognostic unfavorable (1.49e-4)" "unprognostic (2.01e-1)" "unprognostic (3.03e-2)" "unprognostic (3.19e-2)" "unprognostic (1.13e-1)" "unprognostic (1.36e-1)" "prognostic unfavorable (1.03e-4)" "unprognostic (9.14e-3)" "unprognostic (1.29e-1)" "unprognostic (2.72e-1)" "unprognostic (7.28e-2)" 18.7 1.9 2.0 2.9 1.8 0.4 8.6 1.1 1.9 9.6 9.1 22.4 21.7 3.8 0.6 36.2 1.7 2.4 1.0 1.6 2.2 1.2 1.2 12.6 1.1 2.7 1.5 0.9 1.2 3.3 3.5 2.3 2.3 3.6 19.7 2.8 6.7 4.7 7.2 12.9 30.9 2.1 1.7 4.6 6.0 5.3 2.4 0.8 1.1 1.1 8.1 7.9 20.2 2.4 0.0 0.0 0.3 2.1 28.2 38.1 0.7 1.8 0.0 4.6 12.6 3.6 10.3 0.0 3.4 2.3 0.0 35.0 0.8 6.9 5.5 2.6 9.7 0.0 33.9 1.5 14.4 1.1 6.1 8.1 0.0 6.5 25.8 60.1 4.4 0.0 0.0 17.1 7.3 2.8 0.0 0.1 1.7 1.7 19.5 0.0 2.4 0.7 10.0 0.0 5.4 0.1 48.0 11.5 35.7 25.8 3.0 0.0 14.8 0.0 0.7 0.1 0.0 13.5 8.4 0.1 0.0 1.0 0.0 0.0 3.3 0.0 0.1 3.3 0.0 0.0 0.2 0.3 0.5 0.0 0.0 0.1 0.0 0.0 9.0 0.0 0.0 1.0 2.0 1.8 1.1 1.9 1.6 2.2 2.7 1.5 2.3 1.7 2.4 2.4 3.5 67.3 6.7 0.3 2.9 5.4 27.0 40.5 5.7 3.2 6.4 9.8 3.1 1.5 37.5 5.5 0.0 1.2 3.2 240.7 0.0 57.7 11.3 31.8 7.5 4.1 7.7 0.0 0.1 38.2 0.8 11.5 30.5 37.2 0.0 0.4 1.8 0.1 1.2 0.0 0.5 31.6 14.2 17.6 3.8 2.7 0.6 5.6 3.6 2.8 3.2 4.8 0.0 1.0 0.5 164.5 75.6 1.2 2.1 65.3 139.0 0.1 17.9 7.2 0.0 2.7 8.9 13.8 3.5 142.0 24.2 3.1 2.9 1.2 23.3 241.6 CDX2 CDX3 ENSG00000165556 "Caudal type homeobox 2" Q99626 13 27960918-27969315 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Developmental protein, DNA-binding" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 8 "intestine: 41.0" "Cell type enhanced" "Detected in some" "Distal enterocytes: 287.5;Intestinal goblet cells: 214.5;Paneth cells: 181.7;Proximal enterocytes: 226.9;Undifferentiated cells: 194.4" "Cancer enriched" "Detected in many" 6 "colorectal cancer: 63.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "CACO-2: 14.4;CAPAN-2: 4.8;HEK 293: 7.7" "Not detected" "Not detected" "Not detected" "Not detected" "CAB002221, HPA045669, HPA049580" Enhanced Enhanced Nucleoplasm NA NA "Cluster 9: Intestine - Unknown function" "Cluster 39: CACO-2 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "CAB002221: AB_563649, HPA045669: AB_2679413, HPA049580: AB_2680823" "unprognostic (1.42e-1)" "unprognostic (2.41e-1)" "unprognostic (2.92e-1)" "unprognostic (8.11e-3)" "unprognostic (4.19e-6)" "unprognostic (1.73e-4)" "unprognostic (1.71e-1)" "unprognostic (1.58e-1)" "unprognostic (5.51e-2)" "unprognostic (6.07e-3)" "unprognostic (1.13e-1)" "unprognostic (1.09e-1)" 0.1 0.0 0.0 5.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 41.0 28.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.1 31.3 0.0 0.0 0.1 0.0 0.0 35.9 1.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 14.4 4.8 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 7.7 0.0 0.2 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 3.0 0.0 287.5 0.0 28.9 0.0 0.0 0.0 0.0 62.4 0.0 0.0 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 214.5 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 6.7 0.0 0.0 0.0 0.0 0.9 181.7 0.0 0.0 0.2 226.9 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.5 0.0 0.0 0.3 0.4 0.0 194.4 0.3 CEBPA "C/EBP-alpha, CEBP" ENSG00000245848 "CCAAT enhancer binding protein alpha" P49715 19 33299934-33302534 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Host-virus interaction, Transcription, Transcription regulation" "Activator, Developmental protein, DNA-binding" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 98.7;liver: 194.7;skin 1: 118.7" "Cell type enhanced" "Detected in many" "Distal enterocytes: 91.6;Hepatocytes: 106.5;Hofbauer cells: 87.0;Suprabasal keratinocytes: 171.8;Syncytiotrophoblasts: 212.3" "Cancer enhanced" "Detected in all" "liver cancer: 70.6" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "basophil: 16.0;classical monocyte: 7.1;intermediate monocyte: 12.3;myeloid DC: 5.1;non-classical monocyte: 15.7" "Group enriched" "Detected in many" 15 "dendritic cells: 5.1;granulocytes: 16.0;monocytes: 15.7" "Cell line enhanced" "Detected in many" "BEWO: 196.9;Hep G2: 110.9;NB-4: 114.1;THP-1: 407.7;U-937: 130.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA052734, HPA065037, HPA067937" Approved Approved Nucleoplasm,Vesicles NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 85: Liver - Metabolism" "Cluster 43: THP-1 - Innate immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm Vesicles "HPA052734: AB_2681931, HPA065037: AB_2685410, HPA067937: AB_2685927" "unprognostic (1.80e-1)" "unprognostic (7.62e-3)" "unprognostic (2.09e-3)" "unprognostic (2.21e-2)" "unprognostic (3.38e-1)" "unprognostic (3.99e-2)" "unprognostic (1.94e-1)" "unprognostic (2.43e-3)" "unprognostic (5.95e-2)" "unprognostic (3.96e-2)" "unprognostic (3.09e-1)" "unprognostic (9.45e-2)" "unprognostic (8.02e-3)" "unprognostic (2.19e-1)" "unprognostic (1.98e-1)" "unprognostic (2.49e-2)" "unprognostic (2.72e-2)" 98.7 2.9 16.2 5.7 17.9 22.6 67.7 18.3 26.9 8.7 10.4 21.0 21.2 2.9 0.8 20.9 4.3 3.0 2.8 15.7 18.8 3.6 194.7 25.5 9.1 27.4 22.4 1.3 9.7 26.8 2.6 16.0 21.3 8.8 11.5 0.6 9.8 3.4 19.1 118.7 20.8 2.5 25.7 7.7 12.5 1.0 24.5 4.1 6.5 4.5 6.3 8.7 14.8 34.8 2.5 5.1 0.1 7.1 55.8 0.0 196.9 0.1 1.5 0.1 0.0 24.8 0.1 0.0 3.0 0.0 1.1 9.4 5.8 0.6 0.0 35.8 7.2 0.1 0.1 110.9 0.9 36.6 42.1 2.2 25.4 0.0 0.2 0.0 0.0 2.8 2.4 0.0 0.0 12.7 0.2 114.1 5.0 61.8 2.7 0.0 0.4 1.1 0.2 17.7 0.4 1.7 0.7 0.5 0.8 6.2 13.7 407.7 0.1 0.1 0.8 0.1 0.9 0.4 0.0 0.2 0.0 130.9 0.0 16.0 7.1 0.0 0.8 12.3 0.7 0.0 0.1 0.5 5.1 0.1 0.2 0.4 2.5 0.0 15.7 0.2 0.0 2.1 16.2 17.9 18.3 26.9 15.7 18.8 27.4 22.4 21.3 25.7 24.5 34.8 5.4 16.0 37.8 0.0 2.8 37.3 20.8 3.3 22.2 0.7 6.2 12.2 0.4 57.2 5.1 0.0 0.0 40.3 14.4 91.6 3.9 0.5 0.0 0.8 0.8 4.9 4.2 5.7 1.9 5.8 44.3 9.5 12.8 1.3 1.3 0.0 2.2 106.5 87.0 0.0 0.3 24.8 4.1 35.0 27.4 0.2 3.1 42.9 5.4 17.8 28.2 8.4 6.2 1.0 0.4 1.9 30.6 1.5 2.0 15.1 42.5 4.9 5.1 0.5 0.0 4.1 3.1 0.2 0.7 29.7 171.8 212.3 5.0 0.3 51.5 12.2 CREBBP "CBP, KAT3A, RSTS, RTS" ENSG00000005339 "CREB binding protein" Q92793 16 3725054-3880713 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, Host-virus interaction, Transcription, Transcription regulation" "Activator, Acyltransferase, Transferase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004212, HPA055861" Supported Supported "Nucleoplasm,Nuclear bodies" No No "Cluster 1: Neutrophils - Mixed function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Nucleoplasm "Nuclear bodies" "CAB004212: AB_626817, HPA055861: AB_2682948" "unprognostic (1.17e-1)" "unprognostic (8.51e-2)" "unprognostic (1.60e-1)" "unprognostic (1.63e-1)" "unprognostic (1.49e-1)" "unprognostic (5.09e-2)" "unprognostic (9.59e-3)" "unprognostic (6.98e-2)" "unprognostic (8.96e-2)" "unprognostic (1.08e-1)" "unprognostic (1.76e-1)" "unprognostic (2.84e-1)" "prognostic favorable (6.24e-5)" "unprognostic (1.47e-1)" "unprognostic (1.74e-1)" "unprognostic (3.97e-2)" "unprognostic (8.23e-2)" 17.4 10.6 5.8 17.1 5.2 52.9 16.8 25.4 11.5 20.9 3.7 18.8 12.5 26.5 12.4 16.5 22.4 16.6 14.4 5.9 3.1 12.0 14.3 15.9 17.6 8.9 6.8 37.3 29.7 18.5 11.3 16.9 2.9 16.1 14.1 13.8 17.2 16.2 29.6 21.0 16.4 19.6 0.4 21.0 16.3 33.2 7.9 29.1 23.3 28.9 20.7 16.6 16.5 6.4 12.3 31.0 39.3 17.4 23.5 23.1 20.4 17.4 28.9 29.2 28.2 28.2 22.4 33.7 20.1 33.3 18.7 23.2 45.7 14.2 32.9 57.5 18.5 26.6 29.2 17.9 26.0 26.9 36.5 20.7 14.2 32.5 38.9 18.0 22.3 17.0 30.9 44.8 16.0 42.0 17.9 13.0 32.3 11.7 12.7 83.4 31.1 26.1 11.2 16.2 32.6 21.5 29.5 28.7 16.8 25.3 25.6 25.9 34.7 35.5 35.2 18.4 16.0 20.8 24.3 63.7 7.2 15.8 25.6 1.9 1.1 0.9 1.7 1.5 0.8 3.7 0.8 1.3 0.7 2.1 0.8 1.1 6.7 1.4 2.9 1.5 0.8 0.9 5.8 5.2 25.4 11.5 5.9 3.1 8.9 6.8 2.9 0.4 7.9 6.4 48.1 44.8 51.6 91.1 38.3 56.2 31.0 16.0 27.3 34.2 34.4 25.7 41.2 40.0 28.0 11.0 25.0 17.4 50.1 31.2 5.9 20.9 43.0 37.2 56.4 35.7 15.0 33.4 88.7 20.3 11.3 39.5 32.1 63.5 30.4 53.1 32.5 29.5 20.9 28.6 89.8 25.3 18.3 44.0 42.8 80.2 56.5 49.0 17.8 87.1 52.5 34.5 43.3 111.6 101.2 27.5 19.5 51.1 35.6 39.8 25.2 10.9 28.2 17.6 46.0 75.8 44.9 35.1 42.2 34.6 58.8 30.8 44.2 36.2 24.6 44.2 CRLF2 "CRL2, TSLPR" ENSG00000205755 "Cytokine receptor like factor 2" Q9HC73 X 1187549-1212723 "Cancer-related genes, Human disease related genes, Predicted membrane proteins" Receptor "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 1.8;gallbladder: 1.3;lymphoid tissue: 1.5" "Cell type enriched" "Detected in some" 4 "monocytes: 100.2" "Cancer enhanced" "Detected in single" "thyroid cancer: 1.0" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 13 "plasmacytoid DC: 1.2" "Lineage enriched" "Detected in single" 13 "dendritic cells: 1.2" "Cell line enriched" "Detected in some" 4 "HMC-1: 16.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in single" "Intracellular and membrane" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 3: Monocytes - Immune response regulation" "unprognostic (7.84e-2)" "unprognostic (7.99e-4)" "unprognostic (6.02e-3)" "unprognostic (2.01e-2)" "unprognostic (1.15e-3)" "unprognostic (2.31e-6)" "unprognostic (1.72e-1)" "unprognostic (5.10e-2)" "unprognostic (4.59e-3)" "unprognostic (1.09e-1)" "unprognostic (1.46e-2)" "unprognostic (9.72e-3)" "unprognostic (6.88e-5)" "unprognostic (7.09e-3)" "unprognostic (4.81e-2)" "unprognostic (2.89e-2)" "unprognostic (1.62e-1)" 0.2 0.0 0.0 1.5 0.0 1.8 0.2 0.0 0.0 0.2 0.0 0.1 0.1 0.1 0.1 0.3 0.0 1.3 0.0 0.0 0.0 0.0 0.1 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.1 0.0 0.0 0.2 0.3 0.2 0.0 0.2 0.3 0.0 0.0 0.3 0.0 0.1 0.5 0.6 0.1 0.0 0.2 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.4 0.0 0.5 0.8 0.1 0.3 2.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.1 0.0 0.0 0.0 16.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.3 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.6 0.9 3.4 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.3 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.9 0.0 0.3 0.0 0.0 20.8 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 1.1 0.0 0.0 1.8 0.0 1.0 100.2 0.0 0.0 0.0 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.1 CRTC1 "FLJ14027, KIAA0616, MECT1, TORC1" ENSG00000105662 "CREB regulated transcription coactivator 1" Q6UUV9 19 18683678-18782333 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Biological rhythms, Host-virus interaction, Transcription, Transcription regulation" Activator "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 37.4;Horizontal cells: 43.7" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in many" 203 "amygdala: 14.2;basal ganglia: 11.4;cerebellum: 27.1;cerebral cortex: 24.3;hippocampal formation: 24.5" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022035, HPA063619" Enhanced Supported "Nucleoplasm,Nuclear bodies,Plasma membrane,Cytosol" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 28: BEWO - Transcription regulation" "Cluster 62: Horizontal cells - Visual perception" "Nucleoplasm, Nuclear bodies" "Plasma membrane, Cytosol" "HPA022035: AB_1847255, HPA063619: " "unprognostic (5.95e-3)" "unprognostic (2.57e-1)" "unprognostic (9.94e-2)" "unprognostic (8.62e-3)" "unprognostic (9.07e-2)" "unprognostic (1.57e-2)" "unprognostic (1.04e-1)" "unprognostic (5.57e-2)" "unprognostic (2.27e-1)" "unprognostic (6.68e-2)" "prognostic favorable (1.80e-5)" "unprognostic (3.37e-2)" "prognostic favorable (3.83e-5)" "unprognostic (6.83e-3)" "unprognostic (1.02e-1)" "unprognostic (2.51e-2)" "unprognostic (2.03e-2)" 8.8 11.3 14.2 5.2 11.4 2.1 8.2 27.1 24.3 11.3 0.0 8.9 4.0 9.3 3.4 5.2 10.3 3.2 10.5 24.5 0.0 12.8 10.4 7.9 4.1 0.0 0.0 9.4 9.8 4.7 23.7 3.9 0.0 11.6 1.5 4.4 7.3 5.1 14.4 7.4 8.5 2.5 0.0 9.6 9.9 11.3 0.0 3.6 14.4 3.6 2.2 9.7 7.4 0.0 5.2 7.9 6.7 10.7 6.3 4.5 18.6 5.4 3.6 5.3 4.8 5.1 6.6 7.1 11.6 5.2 3.9 5.5 2.1 3.5 1.3 3.1 15.1 6.0 7.8 9.3 5.5 8.3 16.3 7.8 2.9 4.4 1.3 6.8 3.1 7.2 4.8 6.3 3.0 15.2 5.7 10.0 8.8 2.7 13.1 8.7 2.9 8.1 3.2 8.0 12.1 10.7 6.0 5.8 7.0 2.2 6.6 5.2 5.4 6.0 9.1 10.8 6.4 4.4 3.6 4.6 6.9 8.6 4.6 0.3 0.6 0.4 0.4 0.2 0.3 0.5 0.5 0.6 0.7 0.7 0.5 0.3 0.2 0.3 0.4 0.8 0.4 0.4 14.2 11.4 27.1 24.3 24.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.9 0.0 5.3 31.0 6.9 2.7 8.9 7.8 5.7 29.1 5.8 6.1 17.7 10.0 3.5 18.4 27.1 9.7 7.9 6.8 11.7 4.6 1.1 9.6 14.0 5.6 19.2 3.6 37.4 6.0 2.7 7.5 8.6 9.8 2.5 14.7 3.9 4.7 8.8 43.7 26.7 7.1 12.2 6.0 4.0 3.2 9.3 6.3 3.6 10.3 5.5 9.1 8.2 12.1 20.2 3.5 9.6 4.9 2.0 3.0 6.1 5.0 4.8 14.7 0.0 14.2 6.6 2.9 8.8 2.4 2.0 10.4 5.1 8.3 5.2 3.6 CSF1R "C-FMS, CD115, CSFR, FMS" ENSG00000182578 "Colony stimulating factor 1 receptor" P07333 5 150053291-150113372 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Immunity, Inflammatory response, Innate immunity" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Neurodegeneration, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 113.3;placenta: 103.3" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 103.2;Hofbauer cells: 340.4;Kupffer cells: 291.2;Langerhans cells: 73.4;Macrophages: 196.3;Microglial cells: 134.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "intermediate monocyte: 444.6;non-classical monocyte: 646.9" "Lineage enriched" "Detected in many" 5 "monocytes: 646.9" "Group enriched" "Detected in some" 4 "BEWO: 123.0;SK-BR-3: 47.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008970, HPA012323" Uncertain Supported "Vesicles,Plasma membrane" "Intracellular and membrane" NA NA 1600000000 "Cluster 51: Monocytes - Innate immune response" "Cluster 64: Macrophages - Immune response" "Cluster 28: BEWO - Transcription regulation" "Cluster 4: Macrophages - Innate immune response" "Vesicles, Plasma membrane" "CAB008970: , HPA012323: AB_1848977" "unprognostic (3.82e-2)" "unprognostic (1.31e-1)" "unprognostic (1.86e-3)" "unprognostic (9.83e-2)" "unprognostic (1.20e-1)" "unprognostic (7.33e-2)" "unprognostic (1.03e-1)" "unprognostic (1.45e-1)" "unprognostic (9.37e-2)" "unprognostic (1.11e-2)" "unprognostic (2.49e-1)" "unprognostic (1.65e-1)" "prognostic unfavorable (1.08e-4)" "unprognostic (3.67e-2)" "prognostic unfavorable (4.92e-4)" "unprognostic (1.72e-2)" "unprognostic (4.61e-2)" 51.3 31.0 19.6 75.1 17.1 5.6 19.3 20.2 21.4 21.6 19.3 21.9 24.3 12.1 5.8 21.0 17.2 40.6 16.6 19.8 33.8 7.1 27.5 36.6 54.4 41.4 35.5 12.7 9.9 11.8 5.7 103.3 40.1 9.1 21.5 1.5 10.1 20.8 3.2 13.4 37.3 41.9 36.6 113.3 21.0 7.0 40.6 14.3 6.0 11.8 21.7 42.6 3.8 67.6 4.5 0.2 0.0 0.0 1.9 0.4 123.0 0.2 0.2 0.0 0.0 3.8 0.0 5.9 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.1 0.1 0.1 0.2 1.1 3.0 0.0 6.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 6.1 0.1 0.0 0.0 0.0 1.9 0.6 0.0 0.0 0.2 0.2 0.0 47.8 0.0 1.9 0.0 20.7 0.0 0.8 0.2 0.1 3.3 0.0 0.3 0.1 6.6 2.6 0.0 3.0 138.4 4.0 0.6 444.6 0.6 0.3 0.2 0.4 139.0 0.2 0.3 0.2 21.6 0.2 646.9 11.1 0.5 132.7 19.6 17.1 20.2 21.4 19.8 33.8 41.4 35.5 40.1 36.6 40.6 67.6 2.0 0.0 3.8 0.0 4.3 2.8 0.0 0.0 1.2 0.0 0.5 2.3 3.1 4.3 0.0 0.0 0.0 6.2 2.8 0.0 0.0 0.0 4.8 0.0 0.1 10.5 0.0 2.5 0.4 0.0 103.2 2.2 1.5 0.2 2.5 8.3 2.9 1.5 340.4 0.0 0.5 0.3 0.0 291.2 73.4 5.4 1.8 196.3 3.6 134.9 39.4 0.0 1.0 1.5 0.3 0.1 1.7 0.0 1.0 0.0 0.0 0.1 0.7 0.5 13.1 1.2 2.0 2.2 0.2 0.4 1.3 26.4 1.3 2.2 0.2 0.0 CSF3R "CD114, GCSFR" ENSG00000119535 "Colony stimulating factor 3 receptor" Q99062 1 36466043-36483278 "Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion" Receptor "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "bone marrow: 379.7;lung: 136.7;lymphoid tissue: 375.6;placenta: 105.1" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 230.8;Cytotrophoblasts: 423.8;Kupffer cells: 177.7;monocytes: 197.6;Syncytiotrophoblasts: 1194.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 7 "neutrophil: 1962.3" "Lineage enriched" "Detected in many" 7 "granulocytes: 1962.3" "Group enriched" "Detected in some" 18 "BEWO: 70.8;NB-4: 20.3;THP-1: 50.3;U-937: 47.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "CAB017116, HPA048086" Enhanced "Intracellular and membrane" NA NA 150000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 28: BEWO - Transcription regulation" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" "CAB017116: , HPA048086: AB_2680257" "unprognostic (5.57e-3)" "unprognostic (8.05e-2)" "unprognostic (7.23e-2)" "unprognostic (3.87e-2)" "unprognostic (2.88e-1)" "unprognostic (2.92e-2)" "unprognostic (2.86e-2)" "unprognostic (1.35e-1)" "unprognostic (1.83e-1)" "unprognostic (5.65e-2)" "unprognostic (2.47e-1)" "unprognostic (3.44e-1)" "prognostic unfavorable (5.72e-4)" "unprognostic (6.33e-2)" "prognostic unfavorable (3.79e-4)" "unprognostic (2.03e-1)" "unprognostic (2.31e-2)" 36.2 7.1 5.8 148.2 5.6 379.7 13.0 6.7 19.0 5.2 6.3 6.4 2.6 3.1 0.4 5.6 31.5 15.8 14.6 5.5 7.3 9.7 22.9 136.7 7.3 10.3 7.8 3.2 4.9 1.6 5.5 105.1 11.4 7.5 1.8 0.1 7.4 1.8 3.6 1.6 9.8 12.2 9.6 375.6 9.9 1.2 10.7 5.7 5.8 21.7 2.7 22.2 6.2 11.9 0.0 0.0 0.0 0.0 0.0 0.0 70.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.5 1.6 2.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 20.3 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.9 0.0 1.5 0.0 50.3 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 47.8 0.0 1.1 280.8 8.7 0.2 56.8 0.6 0.1 0.4 0.2 97.2 0.4 0.1 0.3 1962.3 3.4 24.1 3.3 0.6 158.4 5.8 5.6 6.7 19.0 5.5 7.3 10.3 7.8 11.4 9.6 10.7 11.9 0.7 25.6 230.8 0.0 3.3 1.0 0.5 0.0 0.0 0.0 5.9 4.7 1.8 0.0 10.0 0.0 0.0 423.8 2.9 0.0 0.0 0.0 0.4 0.3 6.4 4.8 0.0 4.6 0.2 0.0 47.3 8.0 1.5 0.2 18.9 1.1 3.9 1.2 64.1 0.0 0.2 0.0 0.0 177.7 39.2 0.7 0.3 111.5 0.0 77.8 197.6 0.2 6.2 0.5 0.3 0.1 0.0 0.0 0.7 0.3 0.0 0.5 6.6 0.2 0.0 0.3 1.0 0.0 0.4 0.2 0.1 1194.8 4.0 0.0 0.0 3.0 CTNNB1 "armadillo, beta-catenin, CTNNB" ENSG00000168036 "Catenin beta 1" P35222 3 41194741-41260096 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cell adhesion, Host-virus interaction, Neurogenesis, Transcription, Transcription regulation, Wnt signaling pathway" Activator "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 539.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000108, CAB001950, HPA029159, HPA029160" Supported Enhanced "Plasma membrane" NA NA 2000000 "Cluster 39: Non-specific - mRNA processing" "Cluster 37: Intestine - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 41: Macrophages - Immune response" "Plasma membrane" "CAB000108: , CAB001950: , HPA029159: AB_10599619, HPA029160: AB_10600996" "unprognostic (2.47e-1)" "unprognostic (3.48e-2)" "prognostic favorable (7.54e-4)" "unprognostic (1.61e-1)" "unprognostic (9.55e-2)" "unprognostic (1.05e-2)" "unprognostic (3.20e-3)" "unprognostic (2.79e-1)" "unprognostic (1.57e-1)" "unprognostic (1.80e-2)" "unprognostic (1.88e-2)" "unprognostic (9.05e-2)" "unprognostic (1.97e-3)" "unprognostic (1.82e-2)" "unprognostic (1.17e-1)" "unprognostic (2.61e-1)" "unprognostic (9.79e-2)" 130.8 112.2 106.7 98.7 85.3 162.4 194.3 147.8 87.5 179.4 94.7 141.2 136.9 149.4 84.4 113.7 131.0 121.8 109.9 88.1 105.3 106.5 147.9 132.9 81.9 101.3 112.9 173.9 93.3 137.2 84.7 200.0 94.0 132.3 134.5 88.8 110.9 126.3 87.3 99.0 142.9 178.4 104.9 92.5 81.8 59.5 129.4 95.6 140.6 89.9 99.5 158.3 109.3 108.4 161.6 210.0 423.6 242.8 226.9 184.7 333.8 179.6 249.7 288.2 284.3 146.3 224.0 131.7 157.8 314.1 129.0 119.6 315.8 510.0 306.2 123.3 215.7 215.5 261.0 523.7 169.5 121.8 99.1 271.6 226.7 345.5 208.7 235.7 258.1 63.0 153.7 80.3 324.1 161.8 87.3 68.3 397.2 211.0 159.3 64.9 281.9 88.3 177.9 494.8 102.9 172.4 296.2 147.1 809.4 509.8 242.1 248.6 340.8 217.1 163.6 139.3 264.0 50.7 82.7 138.4 221.5 150.5 369.7 4.7 7.3 6.4 9.2 12.3 10.9 7.7 8.6 10.1 11.8 8.0 8.6 9.4 6.6 9.6 12.6 10.0 10.8 5.6 106.7 85.3 147.8 87.5 88.1 105.3 101.3 112.9 94.0 104.9 129.4 108.4 171.7 137.8 179.5 58.1 71.7 213.5 130.1 75.3 116.1 40.7 232.5 168.1 84.7 90.1 119.2 62.5 33.3 318.9 99.0 251.6 35.2 132.2 11.0 90.3 125.9 187.3 93.8 43.8 50.9 78.5 115.6 116.8 53.0 95.5 116.6 137.0 139.2 172.5 115.1 13.5 82.4 145.9 42.7 154.6 228.1 9.5 59.7 161.1 202.7 124.6 98.3 89.2 49.4 70.9 62.9 139.8 249.5 86.9 55.5 128.3 160.3 93.2 96.1 62.0 46.0 175.6 137.3 78.4 40.1 70.9 174.9 539.5 77.0 245.6 189.6 127.9 DAPK1 "DAPK, ROCO3" ENSG00000196730 "Death associated protein kinase 1" P53355 9 87497228-87708634 "Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Apoptosis, Translation regulation" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 139.1;Excitatory neurons: 120.2;Inhibitory neurons: 155.9;Kupffer cells: 85.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "classical monocyte: 6.7;eosinophil: 8.7;intermediate monocyte: 14.0;myeloid DC: 4.8;non-classical monocyte: 15.2;plasmacytoid DC: 6.2" "Group enriched" "Detected in many" 56 "dendritic cells: 6.2;granulocytes: 8.7;monocytes: 15.2" "Cell line enhanced" "Detected in many" "HMC-1: 97.6;HUVEC TERT2: 56.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB037302, HPA040472, HPA048436" Approved Approved Centrosome NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 3: HMC-1 - Innate immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Centrosome "CAB037302: AB_1078622, HPA040472: AB_2677001, HPA048436: AB_2680390" "unprognostic (2.55e-1)" "unprognostic (1.47e-1)" "prognostic unfavorable (2.48e-5)" "unprognostic (2.77e-1)" "unprognostic (1.74e-1)" "unprognostic (3.47e-2)" "unprognostic (1.74e-1)" "unprognostic (1.75e-1)" "unprognostic (1.88e-2)" "unprognostic (5.77e-3)" "unprognostic (2.19e-2)" "unprognostic (2.77e-3)" "unprognostic (8.31e-3)" "unprognostic (8.76e-2)" "unprognostic (2.40e-1)" "unprognostic (1.68e-1)" "unprognostic (1.09e-3)" 22.9 5.9 12.1 11.8 16.4 5.4 5.9 2.2 20.5 9.6 12.6 27.1 10.1 7.9 18.8 5.5 15.2 28.0 5.2 22.8 7.6 22.0 27.6 37.5 12.5 7.6 7.6 46.0 29.2 6.7 23.4 27.3 13.8 5.2 9.2 11.5 13.7 8.5 1.8 5.0 14.4 9.4 7.8 22.8 19.5 8.1 8.6 41.8 9.8 2.3 6.8 14.5 3.8 7.5 0.0 47.5 22.5 15.8 0.7 0.3 35.4 3.1 4.4 18.3 20.4 6.8 0.3 0.4 4.7 1.0 0.2 43.9 13.9 1.0 7.9 0.4 11.4 23.4 6.6 23.7 19.5 0.0 97.6 1.4 7.5 3.5 1.4 28.5 56.3 6.5 17.8 9.6 15.4 1.5 7.0 0.0 25.4 44.4 0.0 2.0 19.8 0.1 50.6 47.6 10.2 11.3 0.0 4.6 20.1 32.7 0.0 15.2 0.4 0.1 0.3 0.1 0.1 36.9 8.1 0.0 0.2 6.4 3.0 1.7 6.7 8.7 0.0 14.0 0.0 0.1 0.0 0.0 4.8 0.0 0.0 0.1 2.0 0.1 15.2 6.2 0.0 3.0 12.1 16.4 2.2 20.5 22.8 7.6 7.6 7.6 13.8 7.8 8.6 7.5 8.8 51.3 72.2 139.1 2.7 3.6 0.8 1.2 0.6 19.4 1.3 2.3 2.4 31.5 24.3 22.0 2.1 6.8 9.5 1.1 1.9 33.8 1.8 30.2 7.9 17.3 0.0 12.8 120.2 23.0 19.0 12.3 26.5 58.6 24.1 22.1 68.9 20.8 22.7 18.5 155.9 9.3 0.0 85.7 18.3 3.1 14.9 57.1 12.4 18.7 41.2 14.6 2.1 6.6 4.7 35.8 1.9 13.5 6.2 3.2 9.6 7.0 10.2 2.9 0.0 1.5 3.9 3.4 7.2 1.6 3.1 14.2 2.8 3.4 3.7 14.9 DAXX DAP6 ENSG00000204209 "Death domain associated protein" Q9UER7 6 33318558-33323016 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Transcription, Transcription regulation" "Chaperone, Chromatin regulator, Repressor" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Rod photoreceptor cells: 111.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002224, HPA008736, HPA008797, CAB025546, HPA065779" Enhanced Enhanced "Nucleoplasm,Nuclear bodies" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 72: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 46: Photoreceptor cells - Phototransduction" "Nucleoplasm, Nuclear bodies" "CAB002224: AB_563688, CAB025546: , HPA008736: AB_1078625, HPA008797: AB_2797218, HPA065779: AB_2685558" "prognostic favorable (6.05e-4)" "unprognostic (2.90e-1)" "unprognostic (9.66e-2)" "unprognostic (4.04e-2)" "unprognostic (8.55e-2)" "unprognostic (1.36e-1)" "unprognostic (1.46e-3)" "unprognostic (3.48e-1)" "unprognostic (1.92e-1)" "unprognostic (8.58e-3)" "unprognostic (1.34e-1)" "unprognostic (2.01e-2)" "prognostic unfavorable (6.32e-7)" "unprognostic (2.43e-1)" "unprognostic (5.37e-1)" "unprognostic (1.26e-1)" "unprognostic (1.04e-1)" 27.5 33.6 6.4 4.0 6.2 8.1 25.3 5.0 12.0 28.4 2.9 27.9 8.1 27.8 18.9 30.8 28.6 7.2 22.3 6.8 5.8 23.2 25.0 24.0 8.7 6.9 5.9 23.8 23.1 19.3 22.1 7.9 5.5 25.1 10.8 5.2 24.2 9.3 35.4 28.8 30.4 10.6 4.8 44.3 25.0 36.7 6.7 23.5 24.2 12.5 27.3 27.2 25.9 9.0 20.8 0.1 38.0 15.6 16.0 16.0 30.1 27.4 76.7 61.5 43.6 1.6 11.8 58.5 14.8 33.3 65.5 11.8 0.3 46.1 62.5 29.9 39.6 52.0 29.9 39.9 26.5 37.0 17.0 27.0 32.5 25.8 31.0 22.7 15.5 16.2 39.1 21.2 32.1 23.2 29.7 54.1 1.2 0.2 9.1 35.2 5.6 41.8 11.7 1.6 49.7 20.2 0.0 0.9 22.7 14.8 17.5 0.5 22.9 26.3 29.1 0.5 0.3 35.4 58.3 66.4 23.3 23.0 27.7 24.1 22.5 47.3 55.6 28.9 54.9 58.8 48.3 61.3 28.2 56.8 44.5 49.6 22.9 62.9 35.1 27.0 59.0 70.5 6.4 6.2 5.0 12.0 6.8 5.8 6.9 5.9 5.5 4.8 6.7 9.0 18.4 6.4 22.8 5.2 45.3 58.5 23.5 36.2 48.3 19.2 25.8 19.4 7.9 18.6 27.6 12.9 18.8 25.2 41.3 23.3 23.5 38.5 15.7 14.5 54.8 23.9 21.0 27.1 3.7 38.3 35.9 25.2 16.8 23.6 37.9 12.9 16.4 14.5 24.3 15.2 3.8 21.2 12.2 17.2 42.5 7.6 17.7 19.7 24.9 6.5 48.8 29.9 52.5 5.0 4.6 45.4 21.8 23.3 38.7 31.8 20.3 14.4 15.6 111.1 13.1 18.7 19.9 63.8 41.5 45.9 60.9 24.8 42.8 24.1 22.0 35.7 DCC "IGDCC1, NTN1R1" ENSG00000187323 "DCC netrin 1 receptor" P43146 18 52340197-53535903 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" Apoptosis "Developmental protein, Receptor" "Cancer-related genes, Disease variant, Mental retardation, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 6.9;testis: 7.6" "Cell type enhanced" "Detected in some" "Early spermatids: 205.7;Excitatory neurons: 439.7;Inhibitory neurons: 455.8;Late spermatids: 174.9;Oligodendrocyte precursor cells: 1305.9" "Cancer enhanced" "Detected in single" "glioma: 0.9" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "AF22: 36.4;U-266/70: 112.5;U-266/84: 57.1" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA055376, HPA069552" Enhanced Approved "Golgi apparatus" NA NA 64000 "Cluster 78: Testis - Spermatogenesis" "Cluster 29: U-266 - Adaptive immune response" "Cluster 68: Oligodendrocytes - Mixed function" "Golgi apparatus" "HPA055376: AB_2682798, HPA069552: AB_2686151" "unprognostic (1.96e-3)" "unprognostic (1.69e-2)" "unprognostic (3.13e-1)" "unprognostic (3.90e-3)" "unprognostic (1.04e-1)" "unprognostic (1.35e-3)" "unprognostic (2.59e-1)" "unprognostic (5.59e-2)" "unprognostic (2.00e-1)" "unprognostic (2.58e-1)" "unprognostic (8.22e-4)" "unprognostic (4.14e-2)" "unprognostic (1.27e-4)" "unprognostic (7.21e-2)" "unprognostic (1.84e-2)" "unprognostic (1.42e-1)" "unprognostic (2.69e-3)" 0.0 0.6 1.2 0.2 6.3 0.0 0.0 0.0 3.9 0.3 0.0 0.2 0.0 0.0 0.2 0.1 0.1 0.0 0.0 6.9 3.6 0.2 0.0 1.4 0.0 0.7 4.7 0.1 0.3 0.0 0.6 0.0 1.5 0.3 0.1 0.3 0.1 1.2 0.0 0.1 0.1 0.0 0.0 0.2 0.2 7.6 1.1 1.0 0.0 0.0 0.3 0.1 0.1 0.9 0.1 0.1 36.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.7 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.4 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.2 0.0 0.1 112.5 57.1 0.0 6.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 6.3 0.0 3.9 6.9 3.6 0.7 4.7 1.5 0.0 1.1 0.9 1.4 0.0 6.0 10.1 0.3 0.0 0.1 0.0 0.0 2.5 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 205.7 0.0 0.0 0.1 0.0 0.0 439.7 0.2 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 455.8 0.0 0.0 0.0 0.0 174.9 1.2 0.2 0.0 54.4 0.0 0.2 0.0 1305.9 58.6 0.0 0.0 1.2 5.7 0.2 0.0 0.3 0.0 0.4 0.0 0.0 0.1 2.6 1.7 0.0 0.0 0.1 0.0 0.0 0.0 0.1 DDIT3 "CHOP, CHOP10, GADD153" ENSG00000175197 "DNA damage inducible transcript 3" P35638 12 57516588-57521737 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Apoptosis, Cell cycle, Growth arrest, Stress response, Transcription, Transcription regulation, Unfolded protein response, Wnt signaling pathway" "Activator, DNA-binding, Repressor" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 170.7" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HHSteC: 784.2;hTERT-HME1: 399.9;SK-MEL-30: 409.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA058416, HPA068416" Uncertain Supported Nucleoplasm No No "Cluster 33: Neutrophils - Chromatin organization" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 30: Epithelial cell lines - Translation" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "HPA058416: AB_2683712, HPA068416: AB_2685985" "unprognostic (1.12e-1)" "unprognostic (5.33e-2)" "unprognostic (2.20e-3)" "unprognostic (4.92e-2)" "unprognostic (7.86e-3)" "unprognostic (2.28e-1)" "prognostic unfavorable (6.55e-4)" "unprognostic (8.55e-2)" "unprognostic (1.26e-3)" "unprognostic (9.40e-3)" "unprognostic (4.92e-2)" "unprognostic (4.16e-2)" "unprognostic (3.52e-2)" "unprognostic (3.70e-1)" "unprognostic (1.62e-1)" "unprognostic (2.56e-1)" "unprognostic (6.76e-2)" 65.3 66.2 90.6 16.1 97.8 196.5 64.3 97.4 145.5 51.0 92.9 52.0 20.7 39.1 109.3 31.6 41.2 32.1 85.1 89.0 99.2 106.4 81.7 55.4 18.8 95.9 98.4 57.4 37.3 80.5 81.4 37.6 97.1 45.5 26.6 123.1 43.3 25.8 44.8 48.7 28.0 29.2 95.5 34.2 44.4 40.9 106.4 17.8 182.1 55.4 17.5 56.2 49.5 129.5 17.8 16.1 10.1 34.5 90.7 61.0 53.8 48.2 106.0 70.1 65.4 57.2 45.7 25.3 46.9 14.3 186.7 21.4 38.5 7.3 72.2 21.0 15.5 19.9 19.9 42.3 784.2 31.8 29.3 175.7 152.7 118.6 399.9 81.7 16.9 26.5 86.4 94.0 31.2 10.8 21.1 41.5 19.7 37.3 37.5 11.8 220.7 22.3 25.0 22.3 20.9 15.3 14.2 16.2 409.0 37.2 34.4 82.8 9.9 47.5 20.2 45.4 42.0 164.4 60.3 26.8 57.4 29.1 85.8 121.1 17.9 48.8 25.1 16.6 22.7 48.3 17.9 23.6 12.8 44.8 34.1 31.1 170.7 35.6 19.4 15.9 23.8 18.0 90.6 97.8 97.4 145.5 89.0 99.2 95.9 98.4 97.1 95.5 106.4 129.5 237.9 19.2 55.1 17.0 96.6 56.3 176.5 93.1 177.0 114.9 86.3 265.7 177.9 37.1 56.7 22.0 91.8 42.3 101.8 265.7 115.4 43.3 9.5 111.3 39.4 62.3 230.7 12.8 9.6 16.0 17.5 115.7 74.5 82.4 204.0 26.3 27.5 20.1 45.7 55.5 14.5 218.4 101.7 30.4 81.6 6.3 28.0 81.5 88.9 6.5 8.2 156.1 17.5 14.1 23.0 33.0 300.0 38.0 43.2 115.1 61.7 61.6 38.1 160.0 13.1 56.9 122.2 77.7 15.6 91.5 45.7 107.8 89.7 37.2 127.2 65.1 DNMT3A ENSG00000119772 "DNA methyltransferase 3 alpha" Q9Y6K1 2 25227855-25342590 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Chromatin regulator, DNA-binding, Methyltransferase, Repressor, Transferase" "Cancer-related genes, Disease variant, Dwarfism, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 127.2;Horizontal cells: 95.9;Rod photoreceptor cells: 143.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "NTERA-2: 59.6;REH: 59.5;SH-SY5Y: 71.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009469, HPA026588" Approved Supported Nucleoplasm NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 9: Photoreceptor cells - Phototransduction" Nucleoplasm "CAB009469: AB_2093990, HPA026588: AB_1847812" "unprognostic (2.38e-1)" "unprognostic (2.94e-1)" "unprognostic (5.65e-2)" "prognostic unfavorable (1.55e-4)" "unprognostic (8.38e-2)" "unprognostic (7.27e-2)" "prognostic unfavorable (1.58e-4)" "unprognostic (2.24e-1)" "unprognostic (7.25e-2)" "unprognostic (2.72e-1)" "prognostic favorable (1.18e-4)" "unprognostic (2.35e-2)" "prognostic unfavorable (2.49e-4)" "unprognostic (1.43e-1)" "unprognostic (1.87e-1)" "unprognostic (1.14e-1)" "unprognostic (2.70e-2)" 5.6 9.0 8.9 9.8 12.6 8.7 6.2 9.3 10.7 9.1 2.4 11.3 6.7 9.3 8.7 6.0 7.5 6.3 5.9 8.8 7.9 11.3 5.3 7.3 11.1 9.0 7.6 13.0 8.3 4.2 11.5 15.7 8.6 7.2 6.6 15.4 6.2 5.9 21.0 4.9 8.9 7.1 5.2 13.4 8.5 5.2 9.4 20.6 6.9 10.2 9.0 7.3 6.2 11.3 1.6 8.1 34.6 8.3 3.8 2.7 45.2 1.9 2.2 4.7 3.8 21.1 13.2 0.0 4.7 4.7 3.5 2.2 3.8 5.2 2.8 5.7 4.3 14.7 12.8 25.4 8.8 2.9 7.6 8.2 2.6 6.0 2.2 9.1 19.5 34.0 18.0 2.9 3.5 20.6 33.7 36.5 59.6 14.3 4.2 59.5 32.5 3.8 2.9 3.4 18.6 71.5 2.7 19.6 6.2 29.5 2.1 16.2 6.8 5.4 4.7 1.0 2.5 5.6 5.1 19.6 2.2 8.4 5.5 2.8 1.0 2.1 2.7 1.7 4.0 1.3 1.7 2.4 1.3 1.6 4.6 3.9 2.5 5.5 2.7 2.3 1.9 1.2 8.9 12.6 9.3 10.7 8.8 7.9 9.0 7.6 8.6 5.2 9.4 11.3 18.5 6.4 13.1 28.1 11.0 5.2 10.2 6.6 5.7 73.3 12.1 9.8 15.8 5.7 9.9 20.2 127.2 40.6 15.3 6.3 5.9 16.9 1.6 13.3 19.1 20.5 13.1 15.8 49.4 9.8 10.7 16.4 9.7 10.7 37.4 37.3 11.0 6.4 23.2 95.9 43.2 11.4 2.0 14.2 3.9 1.9 19.3 13.7 7.2 38.4 7.4 20.6 13.4 36.7 63.4 9.3 9.4 15.4 9.8 12.4 6.2 6.6 7.3 143.5 19.7 15.1 14.3 2.8 14.6 8.1 2.6 32.2 19.6 26.1 12.1 10.2 DUSP22 "JKAP, JSP1, MKPX, VHX" ENSG00000112679 "Dual specificity phosphatase 22" Q9NRW4 6 291630-351355 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protein phosphatase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RPMI-8226: 270.6;U-266/70: 130.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031394 Approved Approved Nucleoplasm,Vesicles NA NA "Cluster 37: B-cells - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 25: RPMI-8226 - Immune response" "Cluster 51: Myeloid cells - Hemostasis" "Nucleoplasm, Vesicles" "HPA031394: AB_10604114" "unprognostic (7.34e-3)" "unprognostic (7.94e-3)" "unprognostic (1.37e-2)" "unprognostic (1.14e-1)" "unprognostic (3.46e-1)" "unprognostic (1.70e-2)" "unprognostic (9.08e-3)" "unprognostic (2.48e-1)" "unprognostic (9.06e-2)" "unprognostic (5.56e-3)" "unprognostic (3.10e-2)" "unprognostic (3.04e-1)" "unprognostic (1.77e-1)" "unprognostic (3.97e-2)" "unprognostic (3.07e-1)" "unprognostic (2.35e-1)" "unprognostic (1.09e-1)" 36.9 16.4 25.6 27.7 29.1 23.7 33.0 27.4 28.8 31.6 21.2 47.8 22.5 28.9 12.2 45.7 25.9 21.3 42.1 25.1 27.1 32.4 32.7 38.5 32.4 32.3 28.5 19.6 40.8 13.2 21.2 27.3 30.3 23.2 16.1 7.8 30.4 15.1 52.3 41.4 33.7 22.0 28.0 43.9 32.7 44.9 29.3 15.0 28.1 37.7 30.5 30.3 36.8 42.7 13.7 8.3 17.3 25.9 19.5 21.5 22.8 9.9 8.0 8.6 10.3 8.8 15.1 28.4 23.3 10.3 18.3 9.4 21.9 18.3 6.1 68.6 25.1 19.3 7.1 24.7 9.9 7.0 24.4 16.2 54.1 6.2 11.3 14.1 24.8 24.0 18.3 92.2 7.2 8.2 10.3 25.1 10.4 10.0 18.7 20.2 11.7 270.6 16.2 5.8 29.7 11.6 8.5 3.4 29.6 37.4 17.6 8.9 34.2 7.7 10.1 7.8 6.0 130.0 98.6 40.0 3.0 19.0 17.7 36.4 32.5 13.6 8.6 26.5 6.2 40.4 6.7 9.1 33.5 33.3 6.1 8.8 21.8 5.9 25.1 28.8 15.9 19.6 25.6 29.1 27.4 28.8 25.1 27.1 32.3 28.5 30.3 28.0 29.3 42.7 45.5 16.0 21.3 5.5 53.7 26.5 22.0 33.3 14.2 5.7 19.4 17.5 40.8 10.0 30.7 5.5 0.0 10.8 51.1 11.7 21.5 24.2 13.4 18.6 8.2 33.4 9.5 8.2 8.5 51.4 7.7 21.9 15.3 12.9 33.0 8.8 21.8 25.0 30.1 0.0 6.1 14.7 32.6 38.6 43.0 20.5 15.5 47.1 46.2 21.5 78.4 14.9 36.0 7.1 25.9 29.2 12.4 9.4 59.7 16.5 23.2 18.2 39.7 3.2 26.3 11.6 22.8 34.5 73.8 42.5 37.1 6.6 21.3 6.8 15.4 27.9 EDNRB "ETB, HSCR, HSCR2" ENSG00000136160 "Endothelin receptor type B" P24530 13 77895481-77975529 "Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins" "G-protein coupled receptor, Receptor, Transducer" "Albinism, Deafness, Disease variant, FDA approved drug targets, Hirschsprung disease, Waardenburg syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 127.8" "Cell type enhanced" "Detected in many" "Adipocytes: 120.5;Astrocytes: 126.3;Hepatic stellate cells: 112.5;Melanocytes: 110.3;Muller glia cells: 116.2;Sertoli cells: 216.9;Skeletal myocytes: 81.3;Smooth muscle cells: 102.1" "Cancer enhanced" "Detected in all" "melanoma: 127.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 68.0;ASC diff: 50.5;SK-MEL-30: 66.0;U-266/70: 40.7;WM-115: 131.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017842, HPA027546" Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 17: WM-115 - Nervous system development" "Cluster 48: Smooth muscle cells - ECM organization" "Plasma membrane" Cytosol "CAB017842: , HPA027546: AB_2672327" "unprognostic (7.75e-2)" "unprognostic (6.73e-2)" "unprognostic (1.41e-3)" "unprognostic (2.59e-2)" "unprognostic (8.37e-2)" "unprognostic (2.45e-3)" "unprognostic (4.17e-3)" "unprognostic (5.43e-2)" "unprognostic (1.02e-1)" "unprognostic (1.38e-2)" "unprognostic (3.40e-2)" "unprognostic (3.01e-2)" "prognostic favorable (7.20e-5)" "unprognostic (1.59e-2)" "unprognostic (3.86e-2)" "unprognostic (4.58e-2)" "unprognostic (6.77e-3)" 58.8 41.2 34.7 19.5 50.8 0.9 39.8 44.6 26.1 18.7 6.7 13.0 20.0 13.1 3.7 8.2 14.1 14.9 28.1 27.5 51.6 33.0 50.9 51.2 10.4 76.2 66.0 4.7 11.4 15.3 9.6 127.8 47.9 25.3 13.2 17.9 27.0 6.9 11.3 12.5 21.9 12.9 97.2 16.8 10.6 2.3 64.9 4.0 31.8 18.8 4.7 23.6 15.5 78.7 5.7 0.0 68.0 0.0 50.5 2.0 1.0 0.0 0.1 0.0 0.0 25.9 0.0 0.0 2.6 0.0 0.1 0.2 0.0 0.0 0.0 0.3 0.3 0.3 0.0 0.0 3.5 0.0 0.2 13.2 0.0 0.0 0.0 0.1 0.6 0.0 0.2 0.2 1.7 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.0 0.1 0.7 0.1 0.1 0.5 0.1 0.0 66.0 8.9 0.0 0.3 0.3 0.6 0.1 0.0 0.4 40.7 24.9 0.1 1.2 0.0 131.8 0.0 0.4 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 34.7 50.8 44.6 26.1 27.5 51.6 76.2 66.0 47.9 97.2 64.9 78.7 120.5 12.8 51.0 126.3 0.2 14.8 1.0 0.0 1.2 5.8 1.2 2.8 10.8 0.0 2.5 0.0 6.2 14.7 0.3 0.1 0.0 0.0 2.9 2.9 20.7 73.3 0.0 0.0 1.3 0.0 13.9 51.1 1.1 35.9 6.3 2.1 112.5 1.1 13.4 0.0 1.6 0.0 0.0 18.7 10.6 2.2 79.9 5.2 110.3 6.5 0.1 116.2 0.0 48.2 0.9 0.1 0.0 2.6 0.1 2.6 0.0 0.1 1.5 4.4 216.9 81.3 102.1 0.4 2.1 0.2 7.2 5.7 1.6 2.5 0.0 1.5 EGF ENSG00000138798 "Epidermal growth factor" P01133 4 109912883-110013766 "Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted membrane proteins, RAS pathway related proteins" "Growth factor" "Cancer-related genes, Disease variant, FDA approved drug targets, Primary hypomagnesemia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "kidney: 110.2;pancreas: 89.5;skeletal muscle: 29.6" "Cell type enhanced" "Detected in some" "Breast glandular cells: 12.9;Breast myoepithelial cells: 8.1;Cardiomyocytes: 8.2;Distal tubular cells: 7.9;Excitatory neurons: 8.5;Inhibitory neurons: 11.2;Muller glia cells: 26.2;Skeletal myocytes: 8.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "EFO-21: 6.4;SK-BR-3: 11.6;U-251 MG: 3.6" "Low region specificity" "Detected in single" "Low region specificity" "Detected in many" NA NA 209000 680000 "Cluster 1: Neutrophils - Mixed function" "Cluster 7: Kidney - Transmembrane transport" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 37: Myocytes - Muscle contraction" "unprognostic (2.83e-2)" "unprognostic (1.02e-2)" "unprognostic (8.50e-3)" "unprognostic (1.88e-3)" "unprognostic (4.24e-2)" "unprognostic (1.64e-3)" "unprognostic (5.06e-4)" "unprognostic (8.30e-2)" "unprognostic (2.21e-3)" "unprognostic (4.25e-2)" "unprognostic (1.80e-2)" "unprognostic (2.95e-1)" "unprognostic (7.72e-3)" "unprognostic (4.64e-5)" "unprognostic (2.63e-1)" "unprognostic (9.80e-5)" "unprognostic (3.92e-3)" 0.0 0.0 1.0 0.1 1.0 0.2 14.7 0.2 0.8 0.0 0.2 0.8 0.0 0.4 2.4 0.7 0.3 1.0 2.8 0.9 2.0 110.2 0.0 0.5 0.0 1.4 0.9 0.0 89.5 0.2 0.4 0.0 1.5 1.4 1.1 13.6 15.7 0.4 29.6 0.7 0.2 0.5 1.2 0.1 0.0 0.1 0.7 0.0 3.0 17.4 0.0 0.4 0.1 1.8 0.2 0.2 1.9 0.0 0.0 0.1 0.0 0.4 1.1 0.5 0.4 0.1 0.0 0.0 6.4 0.6 1.6 0.0 0.3 0.0 0.4 0.0 0.3 0.1 0.6 1.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 1.4 0.0 0.0 1.3 0.1 0.6 0.1 0.0 0.0 2.3 0.0 0.4 0.1 0.1 0.5 0.4 0.2 0.0 0.0 0.0 11.6 0.4 1.2 2.8 0.0 0.0 0.9 1.3 0.0 3.6 0.0 0.0 0.0 1.1 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.5 1.0 1.0 0.2 0.8 0.9 2.0 1.4 0.9 1.5 1.2 0.7 1.8 0.1 0.0 0.0 3.3 0.0 1.0 0.2 0.1 0.0 1.0 12.9 8.1 8.2 0.0 0.5 0.0 0.0 0.0 0.2 2.0 7.9 0.2 5.6 0.2 0.1 0.6 0.0 0.0 8.5 5.7 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.1 1.7 11.2 0.1 0.0 0.0 0.0 1.5 0.0 1.0 0.0 0.0 0.3 26.2 0.0 1.5 0.3 1.0 0.4 0.0 0.0 1.1 0.1 1.2 1.0 1.2 0.0 8.2 0.2 0.5 0.4 0.0 1.4 0.0 0.1 0.1 1.6 0.3 EGFR "ERBB, ERBB1" ENSG00000146648 "Epidermal growth factor receptor" P00533 7 55019017-55211628 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" "Host-virus interaction" "Developmental protein, Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 287.9;Skeletal myocytes: 251.2;Syncytiotrophoblasts: 376.8" "Cancer enhanced" "Detected in all" "glioma: 136.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in many" 13 "A-431: 5282.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000035, HPA001200, HPA018530, CAB068186, CAB073534" Enhanced Enhanced "Plasma membrane,Cell Junctions" "Secreted to blood" NA NA 4740000 88000000 "Cluster 31: Skin - Epidermis development" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane, Cell Junctions" "CAB000035: , CAB068186: AB_2665679, CAB073534: , HPA001200: AB_1078723, HPA018530: AB_1848044" "unprognostic (2.62e-2)" "unprognostic (9.56e-3)" "unprognostic (1.59e-1)" "unprognostic (7.51e-2)" "unprognostic (1.08e-1)" "unprognostic (1.27e-2)" "unprognostic (6.11e-2)" "unprognostic (4.88e-2)" "unprognostic (2.85e-2)" "unprognostic (3.30e-3)" "unprognostic (1.78e-3)" "unprognostic (1.04e-1)" "unprognostic (1.93e-3)" "unprognostic (6.98e-3)" "unprognostic (1.72e-1)" "unprognostic (6.62e-2)" "prognostic unfavorable (2.04e-5)" 27.9 11.4 12.6 4.0 18.3 0.0 20.0 16.6 9.7 20.4 10.5 12.2 5.7 11.4 10.3 23.5 13.9 9.0 7.1 6.3 10.3 11.6 35.3 14.9 2.5 10.4 19.0 15.1 15.8 3.5 2.9 67.9 8.9 16.2 10.7 10.2 22.1 15.0 10.9 51.0 9.5 9.3 7.5 5.1 11.1 4.2 22.6 12.8 20.6 20.6 8.3 14.7 24.1 6.3 5282.1 61.9 16.5 22.4 102.7 63.5 16.7 47.9 68.7 30.8 23.8 11.5 54.2 2.7 11.4 43.8 130.7 197.1 0.4 230.2 37.1 2.2 3.6 0.1 27.3 3.4 27.0 0.0 0.2 31.2 205.4 74.1 409.9 45.5 4.0 0.0 0.0 0.5 68.0 3.0 0.1 0.1 5.1 21.2 30.4 0.1 9.1 0.2 38.1 52.6 0.8 20.0 42.7 50.6 9.3 16.8 4.9 12.0 15.6 27.1 7.2 215.7 45.8 0.1 4.8 3.1 37.9 1.6 8.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.6 18.3 16.6 9.7 6.3 10.3 10.4 19.0 8.9 7.5 22.6 6.3 16.4 96.1 49.9 147.6 1.2 85.8 77.1 101.5 116.1 3.5 12.1 30.4 11.1 47.1 50.6 22.0 6.2 287.9 0.0 45.9 0.0 32.9 4.9 25.9 57.2 12.5 4.2 8.0 1.2 24.3 37.1 91.6 22.4 39.8 0.0 50.6 6.8 79.5 28.3 0.0 107.5 21.6 48.8 7.7 11.6 5.8 128.3 1.9 17.8 40.3 1.6 90.0 0.0 63.3 1.4 54.8 19.9 133.5 0.0 75.4 14.1 13.4 21.7 3.8 78.9 251.2 34.7 2.4 2.5 73.3 89.9 376.8 2.2 41.9 24.9 55.8 ELK4 SAP1 ENSG00000158711 "ETS transcription factor ELK4" P28324 1 205597556-205632011 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding, Repressor" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Bipolar cells: 104.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 4 "basophil: 6.6" "Lineage enriched" "Detected in many" 4 "granulocytes: 6.6" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA028863 Uncertain Supported Nucleoplasm NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 3: HMC-1 - Innate immune response" "Cluster 44: Endometrium - Transcription" Nucleoplasm "HPA028863: AB_10602492" "unprognostic (2.08e-1)" "unprognostic (2.71e-2)" "unprognostic (1.98e-1)" "unprognostic (1.59e-1)" "unprognostic (2.15e-1)" "prognostic favorable (4.65e-4)" "unprognostic (2.97e-1)" "unprognostic (1.48e-1)" "unprognostic (1.19e-1)" "unprognostic (3.53e-1)" "unprognostic (1.27e-2)" "unprognostic (2.64e-1)" "prognostic unfavorable (2.94e-6)" "unprognostic (2.21e-2)" "unprognostic (1.26e-1)" "unprognostic (1.08e-1)" "unprognostic (5.58e-3)" 9.0 4.9 7.4 11.5 11.0 11.7 8.1 12.2 7.5 8.2 7.0 6.9 6.1 7.7 7.2 8.0 6.7 9.2 7.0 6.0 6.4 7.8 13.2 9.7 17.5 8.5 8.8 6.7 8.1 7.8 5.5 7.9 9.9 26.0 6.8 9.3 8.2 5.7 10.6 13.5 9.6 6.1 9.1 15.8 7.7 7.3 8.5 14.1 6.9 8.7 16.8 9.6 9.3 14.1 14.9 13.2 5.1 13.3 11.9 15.2 12.9 9.8 10.1 7.6 8.9 5.7 14.6 31.3 9.0 12.2 5.7 18.0 10.9 12.0 13.1 35.9 7.7 13.6 22.0 12.2 16.1 25.7 51.8 13.4 14.5 12.0 24.4 14.7 32.3 14.8 12.7 25.6 10.7 20.1 21.3 9.5 8.5 3.4 7.8 15.7 31.2 25.4 10.2 32.0 5.9 7.0 25.2 13.7 17.3 8.9 12.7 8.5 23.5 15.3 17.8 13.7 18.8 19.1 18.9 21.1 13.3 10.3 18.2 6.6 0.4 0.7 0.8 0.5 1.1 0.7 0.9 1.1 0.6 1.1 1.1 1.6 0.2 0.6 0.3 0.8 1.0 0.4 7.4 11.0 12.2 7.5 6.0 6.4 8.5 8.8 9.9 9.1 8.5 14.1 50.7 9.6 16.2 7.2 39.3 39.4 35.3 19.0 9.6 104.8 15.1 11.9 20.8 34.3 17.8 31.3 12.5 15.6 34.0 13.8 3.9 14.7 17.4 37.7 37.4 40.1 13.1 21.4 22.8 17.8 6.2 23.2 18.3 82.5 28.5 12.8 36.4 30.2 10.0 25.2 11.7 18.3 14.2 23.5 39.1 19.5 25.4 22.3 30.2 27.2 22.3 11.2 39.1 17.6 28.0 17.5 9.0 15.4 18.6 71.3 14.4 17.5 24.9 26.9 26.3 28.5 21.4 24.6 11.6 19.2 48.6 18.3 32.6 16.7 17.5 103.1 EP300 "KAT3B, p300" ENSG00000100393 "E1A binding protein p300" Q09472 22 41092592-41180077 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, Cell cycle, Host-virus interaction, Transcription, Transcription regulation" "Acyltransferase, Transferase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000146, HPA003128, HPA004112" Supported Enhanced Nucleoplasm NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 44: Endometrium - Transcription" Nucleoplasm "CAB000146: AB_2533138, HPA003128: AB_1078745, HPA004112: AB_1078746" "unprognostic (7.67e-2)" "unprognostic (5.56e-2)" "unprognostic (2.29e-1)" "unprognostic (2.52e-1)" "unprognostic (6.10e-3)" "unprognostic (1.66e-1)" "unprognostic (2.21e-2)" "unprognostic (2.13e-1)" "unprognostic (1.54e-1)" "unprognostic (8.97e-2)" "unprognostic (1.74e-2)" "unprognostic (8.54e-2)" "prognostic favorable (7.45e-5)" "unprognostic (7.97e-2)" "unprognostic (1.41e-1)" "unprognostic (1.01e-1)" "unprognostic (8.66e-2)" 15.7 13.7 6.8 17.7 8.9 65.1 14.2 20.5 10.8 16.0 6.1 16.6 13.6 17.2 13.5 16.3 16.4 14.2 11.5 7.1 9.4 13.1 15.5 14.7 17.6 10.6 7.8 23.9 18.0 23.2 13.4 19.3 7.7 15.0 14.5 17.8 15.0 15.6 20.4 18.9 16.0 16.4 5.3 17.0 14.5 19.6 8.6 27.2 20.2 23.4 17.9 15.4 14.8 11.2 31.6 21.7 35.4 23.0 22.2 23.3 32.3 15.0 21.8 21.0 21.0 27.8 12.0 32.7 12.2 28.4 18.7 24.1 48.1 20.8 23.5 30.5 32.2 24.4 25.4 22.3 26.9 59.3 26.5 24.8 22.2 30.0 27.0 19.3 24.9 18.7 26.3 43.9 18.3 12.5 16.2 18.9 27.5 38.3 15.2 33.7 16.7 21.3 20.3 40.4 11.3 11.9 51.1 26.0 25.6 29.5 17.8 33.9 31.3 20.3 24.8 16.3 20.8 28.5 14.1 47.9 16.3 17.4 21.5 3.6 1.7 1.6 1.6 1.9 1.5 2.2 1.7 1.7 2.1 1.4 1.4 1.1 4.9 2.7 1.0 1.6 1.4 1.2 6.8 8.9 20.5 10.8 7.1 9.4 10.6 7.8 7.7 5.3 8.6 11.2 45.4 67.3 49.2 58.1 53.8 24.6 22.9 11.6 40.9 44.6 35.1 25.8 31.6 38.6 15.8 25.8 35.5 18.4 63.2 37.0 3.9 16.1 15.3 55.1 56.4 36.2 24.7 60.4 71.8 18.7 17.9 32.0 27.5 72.5 25.3 36.1 32.9 29.2 18.4 25.2 73.6 24.2 2.0 60.7 25.7 6.4 28.9 60.5 8.8 45.9 52.0 27.7 40.2 81.4 80.3 25.8 28.9 30.5 51.2 30.8 20.2 10.8 22.8 30.9 26.3 47.6 36.7 22.8 31.2 35.3 25.9 30.2 46.0 36.7 23.7 36.3 EPAS1 "bHLHe73, HIF2A, HLF, MOP2, PASD2" ENSG00000116016 "Endothelial PAS domain protein 1" Q99814 2 46293667-46386697 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Angiogenesis, Differentiation, Transcription, Transcription regulation" "Activator, Developmental protein, DNA-binding" "Cancer-related genes, Congenital erythrocytosis, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lung: 412.0;placenta: 445.6" "Cell type enhanced" "Detected in many" "Adipocytes: 831.5;Endothelial cells: 425.8;Hepatic stellate cells: 538.7;Syncytiotrophoblasts: 349.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 18 "basophil: 20.6;eosinophil: 8.4" "Lineage enriched" "Detected in single" 26 "granulocytes: 20.6" "Cell line enhanced" "Detected in many" "BEWO: 267.3;BJ hTERT+: 266.7;HHSteC: 326.3;RT4: 339.8;TIME: 337.8;U-138 MG: 284.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031200, HPA069697" Supported Nucleoplasm,Cytosol NA NA "Cluster 46: Basophils - DNA binding" "Cluster 82: Adipose tissue - ECM organization" "Cluster 15: RT4 - Unknown function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Nucleoplasm Cytosol "HPA031200: AB_2673785, HPA069697: AB_2732139" "unprognostic (1.74e-1)" "unprognostic (9.47e-2)" "unprognostic (1.29e-2)" "unprognostic (2.74e-1)" "unprognostic (5.25e-2)" "unprognostic (1.75e-1)" "unprognostic (2.22e-2)" "unprognostic (8.67e-2)" "unprognostic (6.00e-2)" "unprognostic (9.72e-2)" "unprognostic (1.55e-2)" "unprognostic (9.29e-2)" "prognostic favorable (2.63e-4)" "unprognostic (6.66e-3)" "unprognostic (7.75e-2)" "unprognostic (7.56e-2)" "unprognostic (1.36e-1)" 296.0 52.1 53.4 66.1 48.6 2.3 166.7 44.6 47.7 72.9 139.1 57.1 46.3 87.9 26.0 72.7 80.1 83.2 122.1 39.2 44.7 89.5 110.1 412.0 47.9 60.5 54.2 34.5 59.6 79.4 25.9 445.6 60.2 51.8 42.6 53.6 40.0 66.3 80.5 42.9 50.9 71.7 45.6 84.6 42.8 20.0 75.4 17.9 138.1 153.6 40.3 94.9 47.8 44.6 32.2 33.5 2.1 2.5 153.8 98.6 267.3 98.7 266.7 55.6 60.1 5.8 5.5 0.1 23.8 188.5 55.2 15.2 0.6 79.0 41.3 0.9 1.6 0.0 10.3 71.8 326.3 0.1 19.8 145.0 106.9 108.7 75.8 41.0 193.1 0.7 3.1 0.2 34.2 27.8 0.9 0.8 1.3 22.4 18.5 1.0 3.7 10.5 34.5 339.8 1.4 68.5 77.4 175.5 21.0 68.3 11.7 14.1 337.8 284.0 8.1 38.3 8.4 0.2 0.2 0.1 207.4 5.4 7.4 20.6 0.1 8.4 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.8 0.0 0.0 0.1 0.1 53.4 48.6 44.6 47.7 39.2 44.7 60.5 54.2 60.2 45.6 75.4 44.6 831.5 76.9 151.7 28.4 4.1 48.2 69.8 108.6 43.9 4.5 27.4 29.5 79.2 32.9 124.9 3.7 10.4 126.2 6.6 112.6 1.9 23.0 12.9 36.1 32.7 425.8 4.2 18.7 1.2 52.4 299.9 76.8 32.1 67.6 41.2 2.3 538.7 78.0 55.5 0.0 1.6 13.9 22.4 60.9 30.3 52.7 12.5 21.4 28.4 155.5 0.6 95.5 0.0 31.2 1.3 26.1 53.7 6.4 3.9 57.8 45.9 30.2 31.7 59.3 282.7 23.3 250.5 1.5 4.6 65.0 33.2 349.7 15.9 4.7 23.6 85.7 ERBB2 "CD340, HER-2, HER2, NEU, NGL" ENSG00000141736 "Erb-b2 receptor tyrosine kinase 2" P04626 17 39687914-39730426 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Transcription, Transcription regulation" "Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Collecting duct cells: 136.1;Distal enterocytes: 111.0;Proximal enterocytes: 121.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "gdT-cell: 5.0" "Lineage enriched" "Detected in many" 4 "T-cells: 5.0" "Group enriched" "Detected in many" 41 "OE19: 6565.0;SK-BR-3: 3115.9" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB000043, HPA001060, HPA001338, HPA001383, CAB020416, CAB062555" Enhanced Enhanced "Plasma membrane,Cytosol" NA NA 980000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 7: Kidney - Transmembrane transport" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane" Cytosol "CAB000043: AB_2335701, CAB020416: AB_442047, CAB062555: AB_2665610, HPA001060: AB_2666185, HPA001338: AB_2666279, HPA001383: AB_1078500" "unprognostic (1.97e-1)" "unprognostic (6.60e-3)" "unprognostic (6.21e-2)" "prognostic unfavorable (8.99e-8)" "unprognostic (2.96e-2)" "unprognostic (1.40e-2)" "unprognostic (1.97e-2)" "unprognostic (9.04e-2)" "unprognostic (1.79e-2)" "unprognostic (1.20e-3)" "prognostic unfavorable (9.17e-4)" "unprognostic (3.92e-1)" "prognostic favorable (2.41e-14)" "unprognostic (9.29e-2)" "unprognostic (1.40e-1)" "unprognostic (3.75e-2)" "unprognostic (1.96e-1)" 13.0 5.4 16.1 12.1 20.5 1.6 56.0 14.3 13.1 37.6 23.3 68.2 63.6 25.2 26.6 102.4 64.2 31.0 57.0 13.3 16.0 73.5 31.1 36.2 4.8 22.4 22.7 23.9 37.6 81.7 17.3 27.0 17.1 55.6 48.5 8.1 68.7 50.5 20.7 91.0 67.3 25.0 18.5 6.9 49.7 11.7 15.4 7.4 56.5 15.0 28.0 40.0 52.9 16.4 38.7 45.7 50.4 31.7 59.3 41.2 67.7 27.2 44.9 58.6 48.9 34.4 102.7 2.9 54.6 62.7 31.5 117.6 2.8 61.2 26.9 5.2 38.6 1.8 36.0 56.3 35.3 0.9 1.0 41.0 56.6 36.2 21.9 56.2 24.4 1.9 6.2 2.4 43.3 59.4 7.1 3.0 90.7 6565.0 11.7 3.9 20.5 5.4 58.9 118.9 9.4 2.6 51.5 3115.9 16.9 62.2 88.1 2.2 2.9 30.2 37.7 37.7 17.6 5.3 3.3 3.6 3.0 0.9 98.5 1.1 0.2 0.4 5.0 0.1 0.3 0.6 0.2 1.4 0.2 0.6 0.5 1.4 1.2 0.4 0.1 0.1 0.2 1.7 16.1 20.5 14.3 13.1 13.3 16.0 22.4 22.7 17.1 18.5 15.4 16.4 3.9 41.7 40.1 12.7 2.2 14.0 19.0 37.1 17.6 4.6 62.7 34.9 20.7 32.9 43.8 136.1 12.5 12.0 5.1 111.0 7.9 30.9 0.3 48.7 13.9 6.1 15.6 1.3 0.9 25.5 84.8 15.7 53.5 61.3 0.0 20.3 11.7 10.7 4.0 6.7 1.0 47.5 42.7 2.2 3.1 1.0 18.3 1.7 10.6 1.0 1.2 24.1 26.8 2.0 1.0 32.5 54.8 23.0 1.1 34.9 121.7 19.5 42.0 5.8 0.0 13.1 12.7 6.8 5.7 43.5 18.9 22.7 2.8 4.4 75.4 31.3 EREG ER ENSG00000124882 Epiregulin O14944 4 74365145-74388749 "Human disease related genes, Predicted membrane proteins, Predicted secreted proteins" "Angiogenesis, Differentiation" "Developmental protein, Growth factor, Mitogen" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 10 "bone marrow: 129.0" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 179.1;Kupffer cells: 133.9;Langerhans cells: 171.1;Macrophages: 570.7" "Cancer enhanced" "Detected in many" "colorectal cancer: 11.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ hTERT+: 270.0;CAPAN-2: 76.7;hTEC/SVTERT24-B: 83.7;U-2197: 181.4;U-87 MG: 307.0" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA054373 Approved Vesicles "Secreted to blood" NA NA 46000 "Cluster 67: Neutrophils - Humoral immune response" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 41: Macrophages - Immune response" Vesicles "HPA054373: " "unprognostic (1.26e-2)" "prognostic unfavorable (1.67e-7)" "unprognostic (4.56e-3)" "unprognostic (3.94e-2)" "unprognostic (2.24e-3)" "unprognostic (1.00e-1)" "unprognostic (1.06e-2)" "prognostic unfavorable (1.45e-5)" "unprognostic (1.07e-1)" "unprognostic (7.34e-2)" "prognostic unfavorable (6.57e-5)" "unprognostic (2.94e-1)" "unprognostic (1.70e-6)" "unprognostic (2.42e-2)" "unprognostic (1.13e-2)" "unprognostic (6.59e-3)" "unprognostic (3.16e-3)" 4.5 0.0 0.3 10.3 0.3 129.0 2.5 0.2 0.5 1.9 0.2 2.0 0.2 0.2 0.2 12.6 0.8 5.7 0.7 0.3 0.1 0.1 0.2 2.7 0.1 0.2 0.1 0.1 0.3 0.0 0.0 0.6 0.4 0.1 3.4 0.1 1.3 0.0 0.2 9.3 1.6 3.0 0.0 0.5 0.2 0.1 0.6 0.1 0.1 0.0 1.0 4.9 4.0 0.3 1.4 41.1 0.0 0.0 3.8 6.6 0.1 9.2 270.0 2.6 1.6 32.5 76.7 0.0 44.1 0.0 20.1 2.4 0.0 59.3 2.7 0.0 0.0 1.2 1.6 1.2 1.1 0.1 0.1 3.9 20.2 83.7 43.5 0.0 0.0 0.0 0.1 0.5 0.2 0.4 0.1 0.1 0.1 0.2 0.6 0.1 0.0 0.1 0.6 1.6 0.0 0.0 27.0 0.2 0.0 0.0 0.1 0.0 0.0 1.6 0.6 181.4 0.0 0.0 0.0 0.2 307.0 0.0 0.2 0.4 0.2 0.5 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.2 0.5 0.3 0.1 0.2 0.1 0.4 0.0 0.6 0.3 4.9 6.4 7.2 0.0 5.7 5.4 5.6 179.1 4.0 0.0 24.4 2.3 18.2 5.7 82.4 0.0 0.0 0.4 2.2 56.3 0.0 1.8 3.7 2.4 0.7 2.5 3.6 17.0 0.1 0.2 0.7 4.4 0.5 3.9 7.0 0.1 0.4 1.9 26.8 0.0 1.8 38.2 16.2 133.9 171.1 1.0 0.3 570.7 7.2 0.0 23.2 0.0 0.0 0.0 0.0 0.8 27.1 0.0 11.7 2.5 32.4 0.2 41.9 0.0 0.0 2.5 3.1 0.5 0.3 3.8 9.2 0.7 3.3 0.2 33.1 7.4 ERG "erg-3, p55" ENSG00000157554 "ETS transcription factor ERG" P11308 21 38380027-38661780 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" DNA-binding "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Adipocytes: 94.4;Endothelial cells: 105.5;Hepatic stellate cells: 69.9;Microglial cells: 88.1" "Cancer enriched" "Detected in all" 4 "prostate cancer: 18.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "HUVEC TERT2: 138.3;MOLT-4: 47.7;REH: 151.5;TIME: 113.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB018377, HPA046598" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Nucleoplasm Cytosol "CAB018377: AB_675518, HPA046598: AB_2679715" "unprognostic (2.14e-1)" "prognostic unfavorable (6.18e-6)" "unprognostic (6.44e-3)" "unprognostic (8.64e-3)" "unprognostic (5.65e-2)" "unprognostic (1.91e-1)" "unprognostic (9.03e-4)" "unprognostic (4.30e-2)" "unprognostic (2.63e-2)" "unprognostic (1.29e-1)" "unprognostic (3.42e-2)" "unprognostic (2.89e-1)" "prognostic unfavorable (3.94e-4)" "unprognostic (4.31e-3)" "unprognostic (3.88e-2)" "unprognostic (2.64e-2)" "unprognostic (5.63e-3)" 24.6 4.1 5.1 7.1 5.5 7.6 20.0 5.0 5.5 10.0 3.0 5.4 3.4 11.6 1.9 5.2 9.1 12.0 12.4 4.5 5.1 12.8 6.1 19.6 7.5 5.9 5.4 4.4 4.9 2.4 2.4 24.3 6.2 7.1 3.4 0.5 3.7 4.3 7.9 4.9 6.5 12.0 4.7 26.6 4.6 1.5 7.0 4.1 10.0 9.9 3.7 9.2 6.9 5.4 0.0 0.0 1.5 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.6 0.0 0.0 0.2 22.3 0.0 0.1 0.9 0.0 0.0 138.3 0.1 0.0 0.0 0.0 1.0 47.7 0.0 0.5 0.0 0.0 151.5 0.0 0.0 0.0 0.1 0.1 0.0 1.1 0.2 0.0 0.0 0.0 0.0 113.4 0.7 2.2 0.5 0.0 0.0 0.0 0.0 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 5.1 5.5 5.0 5.5 4.5 5.1 5.9 5.4 6.2 4.7 7.0 5.4 94.4 0.0 3.9 0.3 0.7 3.4 1.7 0.6 3.4 0.0 0.6 4.3 3.8 4.3 1.3 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.7 0.7 0.4 105.5 0.0 13.5 13.3 0.0 0.0 5.7 0.0 2.1 24.0 4.4 69.9 1.3 0.3 0.0 1.7 0.4 0.0 5.9 3.4 2.1 0.9 0.9 3.6 88.1 0.2 0.0 0.0 7.1 1.4 0.0 0.0 0.0 1.5 1.4 0.0 0.0 0.0 0.1 0.0 2.4 3.7 0.3 1.4 0.5 3.4 0.0 0.6 0.5 0.3 0.6 ESR1 "ER-alpha, Era, ESR, NR3A1" ENSG00000091831 "Estrogen receptor 1" P03372 6 151656691-152129619 "Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding, Receptor" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "cervix: 83.8;endometrium 1: 110.9;fallopian tube: 64.9" "Cell type enhanced" "Detected in many" "Breast glandular cells: 86.6;Endometrial ciliated cells: 77.9;Endometrial stromal cells: 79.9;Glandular and luminal cells: 98.9;Hepatocytes: 52.1;Horizontal cells: 62.2;Skeletal myocytes: 56.7" "Cancer enhanced" "Detected in many" "breast cancer: 40.2;endometrial cancer: 24.3" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 10 "MCF7: 46.0;T-47d: 57.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "CAB000037, HPA000449, HPA000450, CAB055099, CAB072858" Enhanced Approved Nucleoplasm,Vesicles NA NA "Cluster 89: Fibroblasts - ECM organization" "Cluster 6: T47d - Mammary gland" "Cluster 44: Endometrium - Transcription" Vesicles Nucleoplasm "CAB000037: AB_563706, CAB055099: AB_2101946, CAB072858: AB_2665701, HPA000449: AB_1078753, HPA000450: AB_1078754" "unprognostic (8.28e-2)" "unprognostic (3.02e-2)" "unprognostic (1.43e-2)" "prognostic favorable (5.47e-7)" "unprognostic (4.79e-1)" "unprognostic (2.43e-3)" "unprognostic (4.10e-5)" "unprognostic (9.92e-2)" "unprognostic (2.20e-1)" "unprognostic (7.17e-2)" "unprognostic (7.35e-2)" "unprognostic (3.45e-1)" "unprognostic (1.20e-2)" "unprognostic (7.91e-3)" "unprognostic (6.45e-2)" "unprognostic (1.25e-1)" "unprognostic (1.52e-1)" 4.2 1.8 3.2 1.5 1.3 0.8 29.1 2.9 1.3 83.8 3.2 0.9 0.4 110.9 1.2 0.5 64.9 1.2 1.8 0.6 6.7 2.8 16.9 2.0 1.6 0.4 0.5 9.0 1.0 0.2 6.6 0.4 0.3 6.1 0.5 3.5 0.9 9.8 5.8 1.1 0.8 50.4 0.2 1.7 0.6 2.3 5.9 1.0 3.4 2.6 2.3 2.1 46.9 0.3 0.6 0.0 0.1 0.1 0.1 1.9 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.1 0.2 0.0 1.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.3 0.2 0.6 0.0 0.0 0.0 1.2 0.1 46.0 0.1 0.0 0.0 0.0 0.0 1.4 0.0 0.7 0.0 3.3 0.1 0.0 0.0 0.6 0.0 0.2 57.4 0.0 0.1 0.2 0.2 0.5 0.0 5.2 1.1 0.1 0.2 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.1 0.2 0.0 0.1 0.1 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.1 3.2 1.3 2.9 1.3 0.6 6.7 0.4 0.5 0.3 0.2 5.9 0.3 0.6 0.0 1.1 1.3 2.3 1.0 1.7 0.0 0.0 3.9 86.6 16.4 4.4 0.0 1.0 0.0 8.4 0.1 0.4 0.1 1.9 0.0 40.1 77.9 79.9 2.7 1.8 0.0 4.5 0.2 0.1 11.3 0.0 98.9 2.5 36.9 5.0 52.1 0.9 62.2 5.4 0.0 0.0 4.0 3.1 10.3 4.1 2.5 1.8 1.0 0.2 2.4 0.0 25.1 0.6 0.1 0.0 2.2 8.5 0.6 0.0 3.7 1.3 4.6 0.0 56.7 11.7 1.8 1.3 0.4 1.7 0.1 2.2 4.8 0.1 6.8 ETNK1 "EKI, EKI1" ENSG00000139163 "Ethanolamine kinase 1" Q9HBU6 12 22625075-22690665 "Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 299.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA010712, HPA029407" Approved Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 5: NTERA-2 - Transcription" "Cluster 23: Spermatids - Flagellum & Golgi organization" "Nucleoplasm, Plasma membrane, Cytosol" "HPA010712: AB_2668349, HPA029407: AB_2673026" "unprognostic (2.06e-1)" "unprognostic (7.48e-2)" "unprognostic (1.23e-3)" "unprognostic (2.19e-1)" "unprognostic (8.79e-3)" "unprognostic (1.31e-2)" "prognostic unfavorable (5.85e-4)" "unprognostic (3.98e-3)" "unprognostic (8.30e-2)" "unprognostic (7.97e-3)" "unprognostic (2.01e-1)" "unprognostic (1.64e-2)" "unprognostic (4.53e-3)" "unprognostic (2.77e-1)" "unprognostic (2.91e-1)" "unprognostic (3.01e-1)" "prognostic favorable (1.75e-4)" 10.1 14.4 13.7 14.5 15.2 12.2 13.7 9.0 15.9 10.8 16.4 27.2 23.3 10.2 19.6 10.8 10.1 14.0 7.3 14.7 28.1 18.4 18.2 12.6 17.4 12.0 14.2 11.7 10.7 10.8 13.7 11.3 15.8 10.9 15.3 18.2 12.4 6.2 6.2 15.3 15.5 7.6 11.1 16.7 45.0 17.8 19.3 23.1 14.5 5.6 14.3 10.8 9.5 17.5 14.8 27.9 30.4 27.5 21.2 21.3 21.7 15.6 12.2 17.4 16.0 20.6 33.3 41.1 14.7 11.6 16.5 10.7 27.1 7.6 28.2 36.8 23.7 34.7 11.5 18.9 20.6 33.9 29.4 13.7 7.2 21.9 17.4 25.8 20.3 15.7 41.8 17.2 22.3 7.7 38.8 67.1 59.3 17.9 20.1 32.7 28.1 32.9 25.6 16.5 9.8 17.8 18.9 13.9 27.1 41.1 24.1 32.1 17.5 12.2 19.9 18.6 25.0 12.9 18.1 46.8 16.2 21.0 23.9 44.0 14.3 15.9 15.4 22.0 15.2 22.2 16.4 14.4 14.1 15.3 17.7 17.7 14.6 17.7 23.4 12.6 20.5 19.2 13.7 15.2 9.0 15.9 14.7 28.1 12.0 14.2 15.8 11.1 19.3 17.5 33.6 48.1 32.2 48.0 55.9 144.3 75.7 34.7 64.9 41.0 56.8 42.2 10.1 45.8 43.8 44.1 50.1 30.1 57.6 116.1 27.4 30.7 299.0 64.2 49.1 34.8 108.3 48.8 104.4 44.5 24.2 38.2 230.4 51.4 34.8 40.9 28.2 41.5 42.9 26.9 104.3 60.7 46.8 88.3 60.0 43.5 24.2 57.0 67.6 84.3 39.1 17.7 43.3 121.2 152.9 39.5 62.9 21.4 63.7 73.8 57.7 33.2 81.6 39.5 39.5 23.3 38.9 49.1 18.5 51.9 170.2 75.4 49.0 41.5 47.8 90.3 ETV1 ER81 ENSG00000006468 "ETS variant transcription factor 1" P50549 7 13891229-13991425 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 119.9;salivary gland: 91.6" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 137.7;Astrocytes: 67.3;Cardiomyocytes: 87.7;Enteroendocrine cells: 198.1;Excitatory neurons: 66.9;Oligodendrocyte precursor cells: 135.7" "Cancer enhanced" "Detected in all" "glioma: 22.5" "Group enriched" "Detected in all" 5 "cerebellum: 119.9;thalamus: 32.8" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AN3-CA: 67.8;hTERT-RPE1: 76.2;SCLC-21H: 79.3;U-87 MG: 157.2;WM-115: 78.8" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebellum: 200.7" "HPA068389, HPA077249" Supported Approved Nucleoplasm No No "Cluster 35: T-regs - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA068389: , HPA077249: AB_2686829" "unprognostic (2.45e-1)" "unprognostic (1.01e-1)" "unprognostic (6.98e-2)" "unprognostic (1.04e-1)" "unprognostic (1.49e-2)" "unprognostic (2.13e-2)" "unprognostic (1.64e-7)" "unprognostic (7.08e-3)" "unprognostic (7.21e-2)" "unprognostic (2.36e-1)" "unprognostic (2.01e-1)" "unprognostic (3.02e-1)" "unprognostic (1.51e-3)" "unprognostic (2.21e-2)" "unprognostic (2.05e-1)" "unprognostic (1.05e-1)" "unprognostic (1.20e-2)" 4.9 23.0 13.6 1.9 10.9 0.2 8.2 119.9 12.1 2.3 0.1 4.1 2.2 4.4 2.3 2.7 1.5 17.3 35.6 14.6 5.6 3.2 3.9 28.7 1.4 4.6 14.0 1.4 3.1 11.5 7.4 3.5 9.0 5.5 4.3 4.5 91.6 12.6 0.8 1.9 3.5 3.5 3.1 9.1 2.6 8.9 32.8 4.7 12.2 2.5 1.9 2.7 1.5 8.1 0.1 4.9 35.5 67.8 12.1 35.4 0.1 3.2 12.1 2.0 8.0 0.0 16.6 0.0 3.6 5.6 9.8 0.4 1.5 3.8 4.3 0.9 1.6 2.1 3.1 0.0 7.1 12.3 4.5 10.7 0.0 23.3 1.9 76.2 15.3 1.1 11.0 0.6 14.6 0.0 0.1 0.0 53.2 2.1 36.5 0.0 21.5 2.9 23.7 0.4 79.3 15.6 0.0 1.2 19.6 12.2 1.2 0.5 8.6 7.0 2.2 13.8 13.4 12.2 4.1 0.0 157.2 0.8 78.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 13.6 10.9 119.9 12.1 14.6 5.6 4.6 14.0 9.0 3.1 32.8 8.1 16.0 19.2 137.7 67.3 0.0 1.0 2.8 0.9 13.6 4.9 5.8 23.6 87.7 28.6 0.7 3.7 0.0 0.6 0.1 0.8 5.9 3.6 25.4 1.3 3.9 11.1 198.1 0.8 66.9 0.9 0.4 17.7 1.1 2.0 2.5 0.2 2.9 13.1 3.4 5.0 45.3 2.4 0.0 7.2 1.6 8.7 1.5 0.7 12.4 28.1 0.0 12.6 0.0 135.7 4.3 0.9 0.1 34.6 1.2 0.6 0.0 3.0 1.4 0.6 19.7 17.4 12.6 1.2 2.1 3.1 1.3 0.3 2.2 9.7 1.2 0.3 ETV4 "E1A-F, E1AF, PEA3" ENSG00000175832 "ETS variant transcription factor 4" P43268 17 43527844-43579620 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 23.3;Cholangiocytes: 17.2;Distal tubular cells: 17.6;Enteroendocrine cells: 14.9;Extravillous trophoblasts: 19.8;Syncytiotrophoblasts: 14.9" "Cancer enhanced" "Detected in all" "testis cancer: 80.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AN3-CA: 177.7;Hep G2: 173.0;SK-MEL-30: 197.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA005768 Approved Supported "Nucleoli rim,Mitotic chromosome" Yes No "Cluster 24: Salivary gland - Salivary secretion" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 38: Extravillous trophoblasts - Unknown function" "Nucleoli rim" "Mitotic chromosome" "HPA005768: AB_1848294" "unprognostic (2.32e-1)" "unprognostic (7.33e-2)" "unprognostic (2.14e-1)" "unprognostic (2.51e-1)" "unprognostic (1.97e-2)" "unprognostic (3.14e-3)" "prognostic unfavorable (2.48e-4)" "unprognostic (1.58e-2)" "unprognostic (5.34e-2)" "unprognostic (8.13e-2)" "unprognostic (7.05e-2)" "unprognostic (3.01e-1)" "unprognostic (7.79e-2)" "unprognostic (2.03e-1)" "unprognostic (7.08e-2)" "prognostic favorable (7.60e-4)" "unprognostic (1.69e-1)" 0.5 2.4 1.2 1.0 1.6 0.0 7.0 0.8 2.2 3.6 0.0 2.0 6.1 2.4 1.0 9.2 2.5 6.4 3.1 1.3 0.8 5.4 1.2 2.2 0.6 1.0 0.9 0.4 7.8 7.9 14.7 5.2 1.4 4.5 1.7 3.0 4.6 3.6 1.3 6.4 4.2 1.4 0.3 0.4 3.8 1.2 0.7 0.3 6.9 2.5 4.8 2.1 5.3 0.9 24.5 67.0 80.4 177.7 3.1 20.1 17.9 7.9 21.1 14.9 15.2 38.1 33.9 0.1 4.3 4.1 36.6 43.6 2.7 40.2 13.2 0.8 0.5 2.3 10.7 173.0 4.3 47.0 20.9 3.6 1.4 56.8 35.0 16.8 32.1 0.3 48.9 0.1 31.0 9.8 0.2 82.9 116.9 123.1 110.9 99.8 9.8 58.9 33.0 17.3 0.1 71.4 2.1 4.5 197.0 43.8 0.8 13.9 15.1 10.6 52.0 15.7 22.1 7.3 47.8 0.1 18.9 8.9 63.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.2 1.6 0.8 2.2 1.3 0.8 1.0 0.9 1.4 0.3 0.7 0.9 0.2 0.0 0.0 1.3 0.0 1.9 2.5 3.6 23.3 3.2 10.4 12.3 1.1 17.2 2.4 0.0 0.0 2.3 0.1 1.1 17.6 6.5 3.1 0.7 0.3 1.5 14.9 0.0 1.6 1.0 19.8 1.9 3.1 1.6 0.0 0.2 0.7 0.0 0.8 0.0 1.0 4.0 2.0 0.3 0.3 6.0 0.3 0.2 3.6 1.0 0.0 10.9 0.0 1.0 0.0 3.7 3.3 0.4 0.0 0.9 1.9 0.1 1.0 0.3 0.0 2.1 1.7 0.0 1.3 3.6 1.1 14.9 0.3 0.1 7.7 4.3 ETV5 ERM ENSG00000244405 "ETS variant transcription factor 5" P41161 3 186046314-186110318 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" DNA-binding "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 94.0;Oligodendrocyte precursor cells: 169.9;Syncytiotrophoblasts: 88.8" "Cancer enhanced" "Detected in all" "melanoma: 50.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "SK-MEL-30: 178.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009590, HPA063065, HPA073889" Approved Enhanced Nucleoplasm NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "CAB009590: AB_2101008, HPA063065: AB_2684936, HPA073889: " "unprognostic (3.85e-1)" "unprognostic (5.81e-2)" "unprognostic (1.54e-2)" "unprognostic (3.30e-1)" "unprognostic (9.00e-2)" "unprognostic (2.56e-3)" "prognostic unfavorable (7.85e-9)" "unprognostic (3.52e-3)" "unprognostic (2.97e-1)" "unprognostic (1.22e-2)" "unprognostic (4.18e-2)" "unprognostic (1.48e-1)" "unprognostic (1.57e-3)" "unprognostic (6.80e-2)" "unprognostic (1.57e-1)" "unprognostic (3.58e-2)" "unprognostic (3.84e-3)" 6.8 39.3 17.1 6.9 22.4 1.4 15.0 17.7 24.4 4.9 9.4 3.4 6.1 8.1 7.3 4.2 5.1 5.6 11.5 17.8 16.8 8.9 7.9 29.6 5.2 20.5 17.1 2.2 17.5 42.2 25.4 17.1 17.7 7.4 3.2 15.9 6.5 5.8 11.9 6.4 3.0 7.4 14.7 10.9 14.8 9.3 17.2 4.8 21.9 7.0 4.2 4.3 4.1 19.6 42.4 28.6 36.1 79.2 21.9 22.7 2.6 35.7 39.7 27.7 29.6 31.7 25.4 1.1 46.4 34.7 41.3 7.1 0.8 27.2 40.7 9.3 1.0 12.4 1.0 36.4 36.3 31.2 22.1 19.9 4.4 44.3 53.7 32.9 41.0 4.4 11.6 14.6 47.5 19.8 4.1 47.7 54.2 12.1 32.4 86.6 36.0 28.7 23.0 9.9 1.6 45.8 8.7 0.4 178.3 14.4 0.1 17.3 40.0 15.0 24.3 38.2 70.5 11.1 49.9 0.3 45.8 24.6 91.6 0.0 0.0 0.0 0.0 0.8 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.2 0.0 0.4 0.4 0.0 0.1 17.1 22.4 17.7 24.4 17.8 16.8 20.5 17.1 17.7 14.7 17.2 19.6 5.7 3.2 68.5 26.1 5.6 15.7 10.6 8.2 45.5 17.8 9.4 30.4 5.7 17.2 2.4 0.0 12.5 57.6 3.1 0.6 3.9 9.4 24.6 2.0 4.3 9.2 10.7 1.7 94.0 9.4 18.8 12.5 15.8 4.7 8.2 0.8 10.4 9.0 56.4 5.0 43.7 2.8 0.0 64.4 19.4 49.0 9.0 27.1 16.0 45.9 2.1 60.4 1.0 169.9 47.5 12.5 1.1 15.4 4.9 3.6 1.5 22.9 1.3 18.8 0.0 25.4 13.6 16.9 14.4 8.7 5.3 88.8 1.9 3.1 1.5 2.7 EZH2 "ENX-1, EZH1, KMT6, KMT6A" ENSG00000106462 "Enhancer of zeste 2 polycomb repressive complex 2 subunit" Q15910 7 148807383-148884321 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Biological rhythms, Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Repressor, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 47.9;lymphoid tissue: 43.0;testis: 27.8" "Cell type enhanced" "Detected in many" "Early spermatids: 109.3;Spermatocytes: 142.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009589, HPA029131" Enhanced Supported Nucleoplasm NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "CAB009589: , HPA029131: AB_2672920" "unprognostic (2.42e-1)" "unprognostic (3.95e-3)" "unprognostic (1.57e-1)" "unprognostic (3.30e-3)" "unprognostic (1.33e-1)" "unprognostic (3.85e-3)" "prognostic unfavorable (2.11e-6)" "unprognostic (2.21e-2)" "prognostic unfavorable (1.96e-4)" "unprognostic (2.32e-3)" "unprognostic (1.58e-3)" "unprognostic (1.69e-3)" "prognostic unfavorable (8.18e-12)" "prognostic favorable (6.97e-4)" "unprognostic (1.83e-1)" "unprognostic (2.12e-1)" "unprognostic (6.67e-2)" 1.5 1.5 1.1 10.1 1.1 47.9 2.7 2.0 1.3 2.7 1.5 7.0 6.4 2.0 1.2 10.8 1.1 1.9 1.2 1.1 1.1 2.1 3.3 2.3 22.1 1.2 1.2 1.6 3.7 1.3 0.5 4.8 1.2 1.3 8.2 3.3 2.8 0.2 2.9 10.7 6.9 2.8 1.0 5.6 4.0 27.8 1.5 43.0 1.3 1.9 21.1 3.5 3.8 1.2 65.6 30.1 99.7 66.9 3.1 5.1 54.6 49.7 19.9 39.9 40.2 45.6 73.2 114.3 23.5 18.7 36.3 39.0 52.1 17.1 50.6 164.9 51.8 48.9 38.4 35.5 8.0 110.1 38.5 4.3 9.6 29.9 15.9 12.1 24.0 108.9 105.9 73.6 36.2 74.0 215.7 91.7 79.6 57.0 39.9 131.3 56.0 70.9 18.6 31.0 95.1 60.3 62.3 46.8 16.5 25.3 34.3 46.7 14.8 42.4 19.8 85.2 90.4 65.7 76.6 115.3 38.6 74.2 84.9 0.4 1.7 1.1 1.2 1.2 0.9 1.1 2.6 2.2 3.8 0.6 1.4 0.9 0.1 7.2 3.6 0.8 8.3 1.2 1.1 1.1 2.0 1.3 1.1 1.1 1.2 1.2 1.2 1.0 1.5 1.2 14.4 0.0 6.7 1.3 14.5 26.5 6.7 6.3 10.2 6.0 15.1 12.2 6.1 2.8 7.1 7.3 35.5 28.8 35.9 14.7 3.9 9.5 109.3 16.3 17.0 9.4 9.0 57.0 6.2 8.5 32.2 9.9 15.8 24.2 21.6 45.9 3.3 2.2 11.9 15.2 9.2 20.5 6.1 9.0 33.6 27.7 3.1 19.1 14.2 14.0 14.9 2.6 12.3 16.6 7.0 12.4 10.5 0.7 37.4 4.8 6.8 1.2 9.7 21.3 6.6 13.8 24.1 142.2 58.2 35.8 29.0 30.5 25.7 4.7 22.1 5.9 FAS "APO-1, APT1, CD95, FAS1, TNFRSF6" ENSG00000026103 "Fas cell surface death receptor" P25445 10 88990531-89017059 "Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins, Predicted secreted proteins" Apoptosis "Calmodulin-binding, Receptor" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 109.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 114.7" "Group enriched" "Detected in all" 5 "granulocytes: 114.7;T-cells: 96.2" "Cell line enhanced" "Detected in many" "HDLM-2: 83.4;Karpas-707: 109.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027444 Uncertain Supported "Nuclear bodies,Plasma membrane,Cytosol" "Secreted to blood" NA NA 11900000 420000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 85: Liver - Metabolism" "Cluster 2: Karpas-707 - Immune response" "Cluster 24: Non-specific - Transcription regulation" "Plasma membrane" "Nuclear bodies, Cytosol" "HPA027444: AB_10601378" "unprognostic (6.84e-2)" "unprognostic (2.88e-3)" "unprognostic (8.38e-3)" "unprognostic (1.94e-1)" "unprognostic (2.35e-2)" "unprognostic (9.56e-2)" "unprognostic (7.00e-2)" "unprognostic (2.05e-1)" "unprognostic (3.01e-1)" "unprognostic (7.70e-2)" "unprognostic (1.26e-2)" "unprognostic (1.98e-1)" "unprognostic (1.52e-3)" "unprognostic (2.10e-1)" "unprognostic (2.32e-2)" "unprognostic (4.95e-3)" "unprognostic (1.65e-1)" 14.1 26.3 3.6 17.0 3.6 20.8 10.9 2.9 4.7 12.7 2.8 16.4 7.0 12.8 10.3 10.8 14.8 15.7 7.5 3.6 3.7 7.2 23.3 21.7 18.9 4.6 3.1 20.1 3.7 2.7 3.7 10.4 4.0 8.9 23.3 3.3 6.5 9.3 2.3 9.4 9.2 15.0 3.5 11.2 4.4 2.6 3.9 14.4 7.3 2.6 15.6 12.9 10.2 4.3 22.7 8.2 5.4 13.9 37.0 51.3 0.0 51.8 50.2 1.7 9.1 0.1 23.4 4.7 19.0 52.1 9.6 4.0 1.0 44.8 3.2 83.4 8.7 0.4 5.2 14.7 31.6 3.4 1.6 69.2 38.7 31.4 66.0 24.5 4.7 17.8 0.0 109.0 44.0 1.4 6.4 3.4 0.6 0.2 1.8 1.4 0.5 5.0 60.7 7.3 0.4 0.2 7.7 0.0 0.8 7.0 13.9 1.0 9.5 15.8 9.0 15.2 12.3 45.3 5.3 0.4 11.8 10.2 4.5 43.1 9.4 30.9 9.9 12.3 13.8 7.5 27.6 19.6 11.5 4.0 3.1 10.0 114.7 3.1 22.1 0.2 96.2 12.8 3.6 3.6 2.9 4.7 3.6 3.7 4.6 3.1 4.0 3.5 3.9 4.3 10.3 57.7 13.8 40.1 12.8 45.9 109.7 53.1 39.9 0.0 5.5 9.5 3.5 12.8 27.5 9.2 0.0 0.4 16.3 24.9 0.0 6.3 11.3 9.2 22.3 8.9 8.4 9.5 8.8 4.3 0.2 35.4 8.6 15.5 3.8 4.9 2.2 19.3 5.5 1.7 2.8 14.4 8.2 7.0 31.7 4.9 19.0 17.7 12.4 17.8 20.9 14.5 10.3 8.0 0.7 6.5 8.7 13.9 32.2 46.0 15.6 14.4 26.3 0.7 6.6 26.8 29.1 11.3 1.1 28.5 43.9 0.4 48.4 11.8 24.4 30.0 FEV Pet-1 ENSG00000163497 "FEV transcription factor, ETS family member" Q99581 2 218981087-218985184 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Differentiation, Neurogenesis, Transcription, Transcription regulation" "Developmental protein, DNA-binding" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 16 "brain: 70.8" "Cell type enriched" "Detected in some" 32 "Enteroendocrine cells: 744.9" "Group enriched" "Detected in some" 10 "pancreatic cancer: 3.0;prostate cancer: 9.9;stomach cancer: 2.4" "Group enriched" "Detected in many" 7 "midbrain: 70.8;pons: 20.1" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "HMC-1: 35.5;SH-SY5Y: 43.8" "Region enhanced" "Detected in single" "midbrain: 1.9" "Group enriched" "Detected in some" 5 "midbrain: 4.8;pons: 2.7" HPA067679 Supported Supported "Nuclear speckles" NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 17: Intestinal endocrine cells - Hormone signaling" "Nuclear speckles" "HPA067679: AB_2685884" "unprognostic (4.58e-1)" "unprognostic (1.60e-1)" "unprognostic (7.21e-2)" "prognostic favorable (4.85e-4)" "unprognostic (2.87e-1)" "unprognostic (3.96e-1)" "unprognostic (1.52e-1)" "unprognostic (2.15e-1)" 0.1 2.3 0.0 0.0 1.7 0.0 0.0 0.0 0.6 0.0 0.0 1.2 4.3 0.0 0.0 0.0 0.1 0.0 0.0 0.6 0.1 0.1 0.0 0.0 0.0 6.2 70.8 0.0 1.3 0.0 2.6 0.0 20.1 2.2 1.8 0.4 0.0 0.0 0.0 0.0 2.1 0.0 0.1 0.0 3.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.1 0.0 0.0 0.0 0.0 35.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 5.1 43.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.6 0.6 0.1 6.2 70.8 20.1 0.1 0.3 0.2 0.2 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 1.2 0.1 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.1 744.9 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 22.7 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.5 0.0 0.2 6.0 0.0 0.0 3.4 1.2 0.0 0.0 0.8 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 1.4 0.1 FGF3 "HBGF-3, INT2" ENSG00000186895 "Fibroblast growth factor 3" P11487 11 69809968-69819416 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted secreted proteins, RAS pathway related proteins" Differentiation "Developmental protein, Growth factor, Mitogen" "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 36 "brain: 3.6" "Not detected" "Not detected" "Cancer enhanced" "Detected in many" "endometrial cancer: 5.4" "Region enriched" "Detected in single" 5 "cerebellum: 3.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enhanced" "Detected in some" "basal ganglia: 3.1" "Not detected" "Not detected" HPA012692 Enhanced "Secreted in brain" NA NA "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 54: Cardiomyocytes - Muscle contraction" "HPA012692: AB_1848526" "unprognostic (6.42e-3)" "unprognostic (7.82e-2)" "unprognostic (1.89e-1)" "unprognostic (3.61e-1)" "unprognostic (7.75e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.1 0.0 0.0 0.1 0.6 0.2 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 FGFR1 "BFGFR, CD331, CEK, FLG, FLT2, H2, H3, H4, H5, KAL2, N-SAM" ENSG00000077782 "Fibroblast growth factor receptor 1" P11362 8 38400215-38468834 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins, Transporters" "Transcription, Transcription regulation" "Heparin-binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Craniosynostosis, Disease variant, Dwarfism, FDA approved drug targets, Holoprosencephaly, Hypogonadotropic hypogonadism, Kallmann syndrome, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Fibroblasts: 176.7;Leydig cells: 192.0;Oligodendrocyte precursor cells: 166.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "AN3-CA: 508.7;BJ hTERT+: 278.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033614, HPA056402" Approved NA NA 78000000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 89: Fibroblasts - ECM organization" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 50: Fibroblasts - ECM organization" "CAB033614: AB_783377, HPA056402: AB_2683118" "unprognostic (9.53e-2)" "unprognostic (7.33e-2)" "unprognostic (2.44e-1)" "unprognostic (1.35e-2)" "unprognostic (4.23e-3)" "unprognostic (7.02e-2)" "unprognostic (6.59e-2)" "unprognostic (2.77e-1)" "unprognostic (1.81e-1)" "unprognostic (3.99e-2)" "unprognostic (7.97e-3)" "unprognostic (4.59e-2)" "unprognostic (7.69e-2)" "unprognostic (6.87e-3)" "unprognostic (5.60e-2)" "unprognostic (4.59e-3)" "unprognostic (1.05e-3)" 95.1 12.8 27.5 15.9 24.6 14.1 87.1 48.8 22.4 79.8 37.2 97.2 8.8 74.2 15.8 35.8 85.9 57.1 89.9 30.9 28.8 40.1 9.1 55.7 16.6 35.9 37.3 108.2 98.6 20.4 57.1 51.3 63.7 60.5 17.9 15.8 31.4 53.6 24.8 35.6 41.7 57.1 30.3 9.9 40.4 20.4 33.4 17.1 33.7 23.3 16.1 79.3 63.9 29.6 12.9 42.0 198.0 508.7 120.1 91.2 142.9 136.7 278.8 90.0 95.8 27.3 6.5 1.8 38.3 127.7 103.9 0.2 90.0 6.8 104.3 39.2 24.1 0.0 7.7 27.8 69.7 31.1 0.6 80.5 0.7 70.9 13.3 45.6 86.9 6.0 11.9 0.4 40.5 12.5 91.5 9.2 145.9 1.6 21.6 86.3 21.1 0.4 35.6 0.3 7.9 19.4 23.4 1.0 5.1 93.4 9.3 5.4 51.4 49.2 28.9 149.6 29.7 2.4 4.1 0.5 60.3 1.7 27.1 0.2 0.3 0.1 1.7 0.1 1.1 0.3 0.7 1.2 0.0 0.6 0.5 1.5 0.6 0.4 0.2 0.2 1.0 0.1 27.5 24.6 48.8 22.4 30.9 28.8 35.9 37.3 63.7 30.3 33.4 29.6 101.0 3.2 15.8 55.8 1.8 31.5 95.9 1.1 37.0 4.4 28.7 77.7 52.5 24.3 5.1 9.2 4.2 8.3 6.3 0.4 0.0 27.3 15.3 48.2 40.6 75.5 25.0 3.6 25.4 65.2 80.5 176.7 3.1 75.3 8.2 40.4 47.5 0.8 25.3 21.9 21.1 0.6 4.1 5.6 75.2 15.0 192.0 11.7 33.8 19.7 1.7 88.1 6.2 166.4 14.2 21.6 0.3 99.6 6.4 94.7 0.1 7.9 1.0 3.3 13.1 118.9 59.9 1.6 14.1 4.8 19.7 10.4 14.1 2.1 0.7 11.7 FGFR2 "BEK, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25" ENSG00000066468 "Fibroblast growth factor receptor 2" P21802 10 121478332-121598458 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" Apoptosis "Heparin-binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Craniosynostosis, Disease variant, Ectodermal dysplasia, FDA approved drug targets, Lacrimo-auriculo-dento-digital syndrome, Mental retardation, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 273.8;choroid plexus: 198.1" "Group enriched" "Detected in many" 5 "Astrocytes: 228.2;Cholangiocytes: 213.1;Oligodendrocytes: 562.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 24 "basophil: 13.2;eosinophil: 3.8" "Lineage enriched" "Detected in single" 58 "granulocytes: 13.2" "Cell line enhanced" "Detected in many" "AN3-CA: 189.0;BEWO: 60.9;CACO-2: 49.6;HaCaT: 55.6;HAP1: 63.7;NTERA-2: 57.8;T-47d: 49.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010886, HPA035305" Uncertain Supported "Nucleoplasm,Vesicles,Cell Junctions" "Secreted - unknown location" NA NA 1200000 "Cluster 34: Basophils - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Cell Junctions" "Nucleoplasm, Vesicles" "CAB010886: AB_259379, HPA035305: AB_10672862" "unprognostic (5.53e-2)" "prognostic favorable (8.79e-4)" "unprognostic (1.08e-1)" "unprognostic (5.23e-2)" "unprognostic (1.73e-1)" "prognostic favorable (9.32e-4)" "unprognostic (1.53e-1)" "unprognostic (4.96e-3)" "unprognostic (1.74e-1)" "unprognostic (1.56e-1)" "unprognostic (1.07e-1)" "unprognostic (3.74e-2)" "unprognostic (1.01e-1)" "unprognostic (6.11e-2)" "unprognostic (2.54e-1)" "unprognostic (6.93e-2)" "unprognostic (2.25e-1)" 5.7 21.3 103.9 8.2 186.8 0.3 22.9 178.9 198.9 19.7 198.1 44.8 10.4 54.6 15.3 25.2 29.6 31.3 5.6 109.9 124.7 26.3 41.0 30.9 2.9 250.9 185.9 18.0 31.0 61.0 6.8 15.7 220.5 27.4 21.2 1.2 59.1 54.6 0.5 109.3 12.2 43.6 165.5 0.8 22.5 7.6 148.0 10.1 54.6 0.2 9.1 16.6 27.4 273.8 7.2 0.4 30.2 189.0 0.1 0.0 60.9 0.4 0.0 0.0 0.0 49.6 1.1 0.1 12.5 2.8 0.1 55.6 63.7 13.0 0.0 0.1 12.7 0.0 0.2 1.2 1.5 0.2 11.7 0.1 26.2 0.0 0.6 0.0 0.0 0.3 0.2 0.2 0.0 11.7 0.2 0.1 57.8 8.7 0.0 0.1 0.0 7.5 18.0 15.8 0.5 0.5 0.4 33.4 0.0 36.6 49.3 0.0 0.1 0.3 8.5 0.2 0.7 0.1 0.1 0.0 0.3 0.0 0.5 13.2 0.0 3.8 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 103.9 186.8 178.9 198.9 109.9 124.7 250.9 185.9 220.5 165.5 148.0 273.8 1.4 19.2 36.0 228.2 0.6 40.1 34.3 18.4 58.6 0.2 8.7 25.4 9.1 213.1 38.4 36.8 0.0 16.5 0.3 7.3 0.0 7.4 4.1 28.1 4.4 1.0 2.4 2.7 14.8 0.2 3.0 9.0 13.3 53.1 0.0 0.1 1.8 5.0 2.3 0.0 31.2 40.8 10.2 0.6 4.4 9.6 1.2 1.1 5.4 10.3 0.6 2.0 1.0 6.0 562.5 0.7 3.0 6.0 0.1 15.0 1.8 13.6 15.3 0.2 0.0 1.6 2.6 0.7 9.9 18.7 27.7 4.0 1.5 0.4 3.8 31.4 FGFR3 "ACH, CD333, CEK2, JTK4" ENSG00000068078 "Fibroblast growth factor receptor 3" P22607 4 1793293-1808872 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" Apoptosis "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Craniosynostosis, Deafness, Disease variant, Dwarfism, Ectodermal dysplasia, FDA approved drug targets, Lacrimo-auriculo-dento-digital syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 148.3;esophagus: 139.7;skin 1: 271.5" "Cell type enhanced" "Detected in many" "Astrocytes: 410.4;Basal keratinocytes: 103.8;Cholangiocytes: 91.5;Suprabasal keratinocytes: 88.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CACO-2: 48.2;HaCaT: 34.9;Hep G2: 80.6;NTERA-2: 36.1;RT4: 64.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004231, HPA067204" Enhanced Supported "Endoplasmic reticulum" "Secreted - unknown location" NA NA 2500000 "Cluster 27: Brain & Skin - Unknown function" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 64: Astrocytes - Nervous system maintenance" "Endoplasmic reticulum" "CAB004231: AB_627596, HPA067204: AB_2685804" "unprognostic (1.34e-1)" "unprognostic (5.29e-3)" "unprognostic (1.49e-1)" "prognostic unfavorable (3.77e-4)" "unprognostic (5.90e-2)" "unprognostic (1.24e-3)" "unprognostic (7.22e-2)" "unprognostic (2.54e-1)" "unprognostic (1.99e-1)" "unprognostic (2.17e-1)" "unprognostic (1.38e-1)" "unprognostic (2.88e-2)" "unprognostic (1.30e-1)" "unprognostic (9.11e-3)" "unprognostic (1.98e-1)" "unprognostic (4.74e-2)" "unprognostic (1.97e-1)" 1.6 1.6 118.0 1.5 140.6 1.4 5.5 115.6 104.0 23.7 37.4 12.2 19.5 1.5 2.8 139.7 2.2 7.9 4.8 100.8 107.6 39.3 40.7 7.4 0.4 144.7 129.2 0.5 76.4 0.2 16.1 9.3 109.8 13.8 5.2 0.2 20.2 15.0 1.3 271.5 14.7 0.4 108.9 4.0 7.8 17.6 148.3 1.7 1.5 0.9 11.1 23.1 60.9 81.2 0.0 3.8 19.5 5.6 0.0 0.3 22.1 2.4 0.3 0.8 0.4 48.2 1.0 0.0 17.8 0.7 0.7 34.9 5.5 0.3 0.3 0.2 19.3 14.2 3.9 80.6 0.1 0.0 0.6 0.0 10.9 0.2 0.1 0.1 0.1 2.3 16.7 0.1 0.0 23.9 0.8 0.5 36.1 19.5 0.1 1.2 1.0 0.3 2.8 64.1 5.7 1.6 1.9 4.0 0.0 22.2 20.4 2.5 1.0 0.0 2.1 0.5 1.6 0.1 0.0 0.0 0.2 1.7 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 118.0 140.6 115.6 104.0 100.8 107.6 144.7 129.2 109.8 108.9 148.3 81.2 2.2 0.0 32.5 410.4 1.1 103.8 4.1 29.8 23.9 0.0 4.8 1.5 3.1 91.5 37.6 14.7 0.0 0.5 1.6 36.1 0.0 5.0 7.9 3.0 1.7 3.4 4.2 0.0 0.5 0.7 12.0 3.2 3.6 4.0 0.0 0.1 16.1 30.4 0.6 0.0 1.3 20.7 4.1 1.2 6.5 1.3 0.6 0.6 12.4 14.0 0.6 0.1 0.0 34.2 2.2 0.4 18.0 0.4 0.0 4.2 21.2 9.9 9.8 0.6 0.0 0.7 2.9 0.4 25.9 55.0 88.7 0.8 0.7 0.1 17.0 12.8 FH ENSG00000091483 "Fumarate hydratase" P07954 1 241497603-241519755 "Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Tricarboxylic acid cycle" Lyase "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 276.4" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 173.5;Early spermatids: 226.0;Syncytiotrophoblasts: 166.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017785, HPA025770, HPA025948, HPA027341" Enhanced Supported Enhanced Mitochondria NA NA 1800000 "Cluster 44: Non-specific - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 25: RPMI-8226 - Immune response" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "CAB017785: , HPA025770: AB_10599603, HPA025948: AB_10602177, HPA027341: AB_10601222" "unprognostic (1.03e-2)" "unprognostic (3.82e-2)" "unprognostic (9.46e-3)" "unprognostic (2.18e-1)" "unprognostic (2.10e-1)" "unprognostic (2.07e-1)" "unprognostic (2.28e-2)" "unprognostic (1.55e-1)" "unprognostic (5.14e-2)" "unprognostic (1.85e-2)" "unprognostic (1.27e-2)" "unprognostic (1.09e-1)" "prognostic favorable (2.76e-7)" "unprognostic (1.05e-1)" "unprognostic (1.05e-1)" "unprognostic (4.41e-2)" "unprognostic (1.24e-2)" 43.4 75.2 30.4 31.0 33.3 31.4 37.3 33.5 42.0 28.9 43.9 66.8 68.2 36.9 26.1 51.1 27.9 23.7 179.0 33.9 33.1 101.8 276.4 26.4 30.0 31.8 31.0 24.9 38.1 95.0 31.1 32.1 32.1 33.5 69.0 58.8 42.0 38.4 213.4 40.3 59.1 42.0 32.4 30.1 53.6 44.4 32.7 31.3 34.6 229.3 40.4 37.5 33.7 33.0 129.2 105.6 97.9 89.0 93.9 110.0 154.9 155.7 121.1 171.6 107.1 152.2 78.0 81.1 100.3 119.9 75.0 178.4 151.7 115.8 148.4 93.5 48.9 76.3 102.2 131.4 84.1 180.2 66.7 80.2 70.7 96.6 108.0 60.2 107.2 175.8 236.3 101.7 126.9 64.3 156.6 120.1 104.5 186.2 223.6 127.4 107.2 365.7 167.4 107.6 125.4 108.4 131.1 153.3 104.0 67.2 117.1 120.9 106.5 76.6 98.9 137.0 264.0 90.3 103.7 97.3 85.7 203.5 112.6 11.9 22.8 4.9 16.1 33.3 21.0 27.2 18.8 15.1 46.7 25.1 22.3 21.1 1.3 18.3 29.1 23.1 23.8 16.7 30.4 33.3 33.5 42.0 33.9 33.1 31.8 31.0 32.1 32.4 32.7 33.0 17.1 38.5 30.2 9.4 25.0 20.0 24.6 69.5 17.1 24.7 19.9 17.5 173.5 35.8 40.0 23.9 14.6 101.6 13.7 44.0 78.2 60.4 226.0 25.4 23.5 18.6 18.0 37.7 12.7 45.0 58.7 25.5 26.5 25.4 19.0 24.9 13.6 80.4 50.7 35.3 14.9 40.6 48.8 18.5 14.4 37.4 23.9 23.9 24.9 8.4 27.9 35.0 10.3 8.0 14.4 29.4 35.7 26.7 41.3 19.0 66.1 86.0 29.2 39.1 39.5 27.7 67.9 84.7 47.1 32.1 18.6 166.1 14.9 48.4 74.2 22.8 FHIT "AP3Aase, FRA3B" ENSG00000189283 "Fragile histidine triad diadenosine triphosphatase" P49789 3 59747277-61251459 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Transcription, Transcription regulation" Hydrolase "Cancer-related genes, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "choroid plexus: 94.0" "Cell type enhanced" "Detected in many" "Astrocytes: 609.8;Inhibitory neurons: 450.5;Microglial cells: 337.3;Oligodendrocyte precursor cells: 1086.7;Oligodendrocytes: 1111.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 4 "naive CD4 T-cell: 87.6" "Lineage enriched" "Detected in all" 12 "T-cells: 87.6" "Cell line enhanced" "Detected in many" "RPMI-8226: 17.5;U-266/70: 34.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002684, HPA018840, HPA018909" Enhanced Approved "Nucleoli fibrillar center,Plasma membrane" NA NA 12000 "Cluster 32: T-cells - Unknown function" "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 29: U-266 - Adaptive immune response" "Cluster 68: Oligodendrocytes - Mixed function" "Nucleoli fibrillar center, Plasma membrane" "CAB002684: , HPA018840: AB_1848538, HPA018909: AB_1848537" "unprognostic (2.36e-3)" "unprognostic (6.38e-2)" "unprognostic (1.59e-1)" "unprognostic (4.42e-2)" "unprognostic (1.10e-1)" "unprognostic (1.08e-2)" "unprognostic (1.18e-1)" "unprognostic (3.16e-2)" "unprognostic (2.77e-2)" "unprognostic (8.49e-2)" "unprognostic (2.36e-1)" "unprognostic (6.77e-2)" "prognostic favorable (1.36e-4)" "unprognostic (1.54e-1)" "unprognostic (5.96e-2)" "unprognostic (1.29e-2)" "unprognostic (1.80e-2)" 5.6 24.4 13.7 6.2 18.3 8.0 9.0 13.0 17.3 5.4 94.0 6.9 6.4 3.5 6.9 5.0 6.6 9.8 15.8 19.7 16.4 24.9 9.6 4.7 7.6 18.9 17.0 6.8 13.0 18.1 7.9 3.0 18.9 5.3 5.8 7.6 8.5 4.7 10.6 8.1 5.3 4.7 15.0 5.0 8.6 5.5 15.9 12.1 11.7 7.2 5.3 6.7 4.2 19.8 0.1 0.0 1.4 0.0 0.6 0.1 2.5 0.1 0.2 0.1 0.0 2.7 4.2 4.0 0.7 0.1 3.0 0.0 12.7 3.2 0.0 2.2 5.0 3.3 2.0 6.4 3.3 8.7 0.1 9.1 5.2 0.2 6.9 0.3 0.0 3.7 2.5 11.9 0.2 3.6 15.2 6.7 1.2 12.2 0.9 11.3 0.0 17.5 15.3 2.0 2.9 4.3 1.5 9.9 10.1 5.3 0.4 0.2 0.0 1.7 0.4 0.1 2.4 34.6 11.3 0.0 4.0 0.1 1.9 6.8 4.6 0.5 2.2 2.9 1.4 4.1 17.2 1.8 5.7 3.1 87.6 15.6 0.8 7.2 1.3 5.8 20.5 11.9 13.7 18.3 13.0 17.3 19.7 16.4 18.9 17.0 18.9 15.0 15.9 19.8 4.1 6.4 10.6 609.8 19.7 7.6 20.7 30.0 46.7 12.6 41.2 31.2 10.0 38.6 17.5 27.6 58.4 42.0 12.4 6.9 78.2 19.1 45.8 14.6 7.9 7.0 7.7 17.7 276.6 4.7 8.5 10.1 18.3 19.0 5.7 25.7 14.6 23.4 20.9 30.3 450.5 12.9 22.4 10.2 7.1 163.0 19.3 12.9 12.4 337.3 8.6 19.7 6.2 1086.7 1111.0 9.7 15.0 9.8 23.8 12.0 20.7 126.6 12.4 20.7 0.0 10.7 6.2 19.1 7.5 33.7 11.2 32.7 11.5 23.0 20.1 18.8 FLCN "BHD, DENND8B, MGC17998, MGC23445" ENSG00000154803 Folliculin Q8NFG4 17 17212212-17237188 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "GTPase activation" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 79.2;Erythroid cells: 81.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB015158, HPA028760" Supported Supported "Plasma membrane,Cytosol" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 72: Non-specific - Transcription" "Cluster 18: U-2197 - ECM organization" "Cluster 6: Erythroid cells - Oxygen transport" Cytosol "Plasma membrane" "CAB015158: AB_2231645, HPA028760: AB_10601323" "unprognostic (1.99e-1)" "unprognostic (1.77e-1)" "unprognostic (1.53e-2)" "unprognostic (1.74e-1)" "unprognostic (3.85e-2)" "unprognostic (3.69e-1)" "unprognostic (3.73e-2)" "unprognostic (1.32e-1)" "unprognostic (3.58e-2)" "unprognostic (3.90e-1)" "prognostic favorable (4.49e-4)" "unprognostic (6.45e-3)" "unprognostic (2.55e-3)" "unprognostic (1.92e-1)" "unprognostic (9.71e-2)" "unprognostic (2.62e-2)" "unprognostic (1.65e-1)" 21.8 19.0 19.0 10.7 25.9 17.7 18.9 27.3 31.6 42.5 18.3 43.7 23.3 37.0 14.5 13.8 25.2 17.0 29.2 31.9 14.0 15.3 28.9 26.8 12.4 21.3 15.2 35.3 15.2 13.1 28.6 13.1 22.0 27.1 10.2 7.2 16.4 13.7 42.7 19.3 26.8 14.5 14.0 29.2 22.4 21.0 19.3 8.6 23.8 18.4 8.0 28.2 25.5 28.3 12.0 30.4 11.5 14.9 36.4 20.6 15.8 11.8 19.1 18.0 24.3 24.3 10.4 6.3 13.8 14.0 40.2 14.4 14.0 7.3 9.3 10.9 12.2 12.4 9.1 13.9 33.6 4.9 33.5 30.3 24.0 27.6 20.8 16.4 14.8 9.2 17.7 16.4 17.6 17.5 8.3 8.4 11.2 17.8 8.1 16.9 52.7 7.3 11.0 14.1 13.6 8.8 11.6 7.5 19.3 70.7 11.1 8.8 15.7 40.6 16.6 56.5 14.1 7.7 7.4 5.7 26.0 10.8 16.6 2.4 2.8 1.6 1.6 3.7 2.2 3.6 1.9 1.4 1.4 3.2 2.1 1.9 6.0 2.8 1.4 1.4 2.9 1.8 19.0 25.9 27.3 31.6 31.9 14.0 21.3 15.2 22.0 14.0 19.3 28.3 8.4 25.6 12.6 17.0 9.2 18.4 12.7 5.7 2.8 20.7 13.2 6.5 23.7 14.3 6.2 7.3 79.2 10.9 5.3 25.0 1.9 12.3 14.5 16.8 11.3 12.5 25.7 81.7 31.3 8.3 7.4 20.6 9.7 15.2 1.3 10.3 27.8 24.1 16.6 47.1 23.7 11.0 16.2 21.6 19.2 20.4 28.0 13.2 10.6 18.7 12.2 13.3 6.2 17.1 32.4 9.8 15.6 20.3 4.4 11.6 36.8 6.1 9.1 18.5 19.7 24.8 11.1 6.3 10.8 5.3 18.2 33.8 10.0 16.3 12.6 13.0 FLI1 "EWSR2, SIC-1" ENSG00000151702 "Fli-1 proto-oncogene, ETS transcription factor" Q01543 11 128686535-128813267 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding" "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 35.8" "Cell type enhanced" "Detected in many" "B-cells: 65.7;Endothelial cells: 84.2;Hepatic stellate cells: 64.6;Kupffer cells: 86.4;Microglial cells: 231.4;monocytes: 68.4;NK-cells: 93.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HEL: 113.9;HUVEC TERT2: 60.5;REH: 49.8;TIME: 63.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA065030, HPA073099" Approved Supported "Nucleoplasm,Nuclear bodies" Yes NA "Cluster 10: Basophils - Unknown function" "Cluster 2: Immune cells - Immune response" "Cluster 36: HEL - Hemostasis" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Nucleoplasm, Nuclear bodies" "HPA065030: , HPA073099: AB_2686572" "unprognostic (1.38e-2)" "unprognostic (7.46e-2)" "unprognostic (6.16e-2)" "unprognostic (3.74e-2)" "unprognostic (6.22e-2)" "unprognostic (4.26e-3)" "unprognostic (1.33e-1)" "unprognostic (8.32e-3)" "unprognostic (2.97e-1)" "unprognostic (9.91e-2)" "unprognostic (1.60e-2)" "unprognostic (1.42e-1)" "prognostic unfavorable (4.60e-4)" "unprognostic (4.79e-2)" "unprognostic (2.07e-2)" "unprognostic (2.62e-1)" "unprognostic (4.79e-2)" 10.2 1.9 3.7 10.9 2.3 12.2 6.0 2.1 2.8 5.7 1.2 3.7 3.2 4.6 1.1 2.8 2.7 6.1 6.2 1.8 2.9 2.1 2.8 10.8 12.3 4.7 2.7 1.2 1.7 3.5 0.7 12.5 4.3 1.9 2.9 0.5 2.2 2.2 2.8 1.7 4.0 5.9 3.5 35.8 4.3 0.9 3.9 17.2 2.9 6.6 10.4 6.7 1.9 2.8 0.2 0.0 5.6 0.0 0.8 1.0 0.1 3.3 9.2 3.8 3.1 0.0 0.0 18.5 31.7 11.1 1.1 0.1 0.8 13.5 4.1 9.0 0.2 113.9 0.5 0.0 6.0 13.7 14.6 0.8 1.1 7.7 17.3 11.1 60.5 25.6 0.0 23.3 0.8 0.0 13.3 8.1 1.8 0.0 3.1 49.8 0.1 19.4 0.0 0.0 0.0 0.0 0.0 0.0 0.2 5.0 0.0 20.4 63.0 0.7 0.0 0.2 3.5 7.3 16.4 16.6 0.1 31.8 5.2 34.5 15.5 24.5 10.1 15.3 11.9 6.8 8.9 8.2 19.1 6.0 3.7 8.2 11.8 12.3 19.1 3.3 11.1 20.1 3.7 2.3 2.1 2.8 1.8 2.9 4.7 2.7 4.3 3.5 3.9 2.8 53.4 6.4 5.3 0.3 65.7 5.1 0.3 1.7 2.2 0.0 0.7 1.3 5.5 5.7 0.1 1.8 0.0 0.4 43.1 0.0 0.0 0.0 0.5 0.4 0.6 84.2 0.0 23.4 0.3 0.0 0.4 5.9 2.0 0.3 22.8 0.0 64.6 1.3 43.2 0.0 1.5 0.1 0.0 86.4 24.7 0.5 1.8 60.3 7.2 231.4 68.4 0.1 93.7 4.0 0.7 0.0 0.0 0.7 56.9 0.3 0.0 0.4 0.8 0.4 6.6 2.1 3.1 0.2 0.1 0.6 4.1 0.3 52.8 0.9 0.2 0.4 FLT3 "CD135, FLK2, STK1" ENSG00000122025 "Fms related receptor tyrosine kinase 3" P36888 13 28003274-28100592 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, RAS pathway related proteins" "Host-virus interaction" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 5.3;brain: 4.9;lymphoid tissue: 6.5" "Cell type enhanced" "Detected in some" "dendritic cells: 24.4;Inhibitory neurons: 59.9;Kupffer cells: 29.1;Langerhans cells: 21.4;Macrophages: 16.9;monocytes: 39.5" "Cancer enhanced" "Detected in some" "breast cancer: 1.8" "Region enhanced" "Detected in some" "cerebellum: 4.9" "Group enriched" "Detected in many" 13 "myeloid DC: 68.7;plasmacytoid DC: 26.2" "Lineage enriched" "Detected in many" 19 "dendritic cells: 68.7" "Group enriched" "Detected in some" 11 "REH: 42.5;THP-1: 26.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA047539 Approved "Endoplasmic reticulum" NA NA 210000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 14: REH - Unknown function" "Cluster 41: Macrophages - Immune response" "Endoplasmic reticulum" "HPA047539: AB_2680080" "unprognostic (2.19e-3)" "unprognostic (3.16e-3)" "unprognostic (6.54e-3)" "unprognostic (9.96e-2)" "unprognostic (3.88e-1)" "unprognostic (3.96e-7)" "unprognostic (7.99e-3)" "unprognostic (1.65e-2)" "unprognostic (5.37e-2)" "unprognostic (1.01e-2)" "unprognostic (1.96e-1)" "unprognostic (1.03e-1)" "unprognostic (4.56e-2)" "unprognostic (3.65e-1)" "unprognostic (3.91e-2)" "unprognostic (2.51e-1)" "unprognostic (2.22e-1)" 0.5 0.1 0.3 3.0 0.2 5.3 1.5 4.9 0.8 0.5 0.1 0.7 0.3 0.2 0.1 0.6 0.4 1.6 0.1 0.2 0.5 1.5 0.5 0.7 6.5 1.3 0.9 0.1 2.8 0.0 0.0 0.0 1.7 0.1 0.8 0.0 0.4 0.2 0.0 0.7 1.6 0.8 0.8 5.7 0.6 0.6 0.8 4.7 0.1 0.3 3.6 1.3 0.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 3.2 0.6 0.0 0.0 42.5 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 26.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 3.6 3.4 0.0 0.8 0.0 0.2 0.0 0.0 68.7 0.0 0.0 0.0 0.1 2.0 0.0 26.2 0.0 2.7 0.3 0.2 4.9 0.8 0.2 0.5 1.3 0.9 1.7 0.8 0.8 0.8 0.0 0.0 0.0 2.3 1.5 0.3 0.0 0.0 0.0 0.0 1.5 1.0 0.4 1.5 0.0 0.0 0.0 0.0 24.4 0.0 0.0 2.7 3.7 0.3 0.1 0.2 0.0 8.2 7.4 0.0 0.0 0.2 0.0 1.1 0.0 0.0 0.7 0.1 0.5 0.0 59.9 0.0 0.0 29.1 21.4 2.3 0.0 16.9 1.8 1.9 39.5 0.0 0.0 1.5 4.2 0.1 0.0 0.0 2.2 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.1 0.2 0.6 0.0 0.6 0.0 1.7 0.0 0.0 0.0 FOXO1 "FKH1, FKHR, FOXO1A" ENSG00000150907 "Forkhead box O1" Q12778 13 40555667-40666641 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Apoptosis, Autophagy, Differentiation, Transcription, Transcription regulation" "Activator, DNA-binding" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 91.0" "Cell type enhanced" "Detected in many" "Astrocytes: 177.3;Endometrial stromal cells: 161.0;Granulosa cells: 177.9;Oligodendrocytes: 131.5;Skeletal myocytes: 131.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "ASC diff: 40.4;Daudi: 45.3;HSkMC: 53.6;U-698: 57.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001252, CAB022326" Approved Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 30: Non-specific - Translation" "Cluster 59: Non-specific - Translation" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 40: Granulosa cells - Unknown function" "Nucleoplasm, Cytosol" "CAB022326: , HPA001252: AB_1078906" "unprognostic (4.72e-2)" "unprognostic (1.81e-1)" "unprognostic (8.54e-2)" "unprognostic (4.35e-1)" "unprognostic (2.42e-1)" "unprognostic (2.52e-1)" "prognostic favorable (3.74e-4)" "unprognostic (6.35e-2)" "unprognostic (1.60e-1)" "unprognostic (8.65e-3)" "unprognostic (1.71e-1)" "unprognostic (1.31e-1)" "prognostic favorable (1.33e-5)" "unprognostic (1.93e-1)" "unprognostic (5.44e-1)" "unprognostic (9.09e-2)" "unprognostic (9.63e-2)" 43.2 9.7 11.2 13.1 16.1 13.8 27.6 10.0 10.9 19.1 16.7 13.8 5.0 39.1 6.5 13.0 25.7 14.5 13.9 9.1 11.8 11.8 38.5 16.8 23.8 14.1 12.7 65.6 16.5 5.3 7.6 11.2 12.7 10.1 9.6 3.9 9.8 10.1 91.0 18.0 10.9 27.0 10.5 15.7 9.5 8.9 11.3 11.6 19.0 22.2 24.0 13.4 17.4 14.3 0.7 1.7 12.4 0.3 40.4 7.9 11.8 1.8 2.5 0.5 0.3 3.7 3.0 45.3 8.1 1.2 1.9 10.7 9.8 5.3 0.7 20.9 10.1 0.0 1.4 10.1 19.1 0.4 1.2 53.6 35.5 0.2 6.7 2.5 31.7 3.3 0.9 14.0 3.1 1.6 0.1 0.6 18.0 6.2 3.1 32.4 14.3 3.6 22.9 5.8 2.6 0.6 1.6 8.5 1.8 14.1 1.5 1.1 18.6 0.3 2.3 0.1 1.1 7.9 3.3 57.8 1.2 2.1 5.7 0.9 0.6 0.5 1.3 0.8 1.8 3.7 3.6 2.2 0.4 5.8 5.5 4.3 2.5 1.4 1.4 0.0 5.1 1.0 11.2 16.1 10.0 10.9 9.1 11.8 14.1 12.7 12.7 10.5 11.3 14.3 57.9 0.0 4.4 177.3 29.3 29.3 19.1 13.0 27.9 3.7 12.9 17.3 11.5 10.0 9.9 9.2 12.5 0.5 22.9 27.5 0.0 11.1 7.2 55.4 161.0 50.2 52.2 3.2 7.4 18.0 3.8 40.8 18.8 118.8 1.3 177.9 84.3 47.9 6.5 5.0 23.0 21.0 8.2 14.6 26.9 4.0 18.6 18.6 12.4 117.1 18.4 5.5 8.2 47.3 131.5 19.5 16.3 13.2 32.9 10.1 7.7 8.8 9.2 9.8 6.6 131.7 31.3 6.4 14.6 25.3 26.7 0.8 40.3 64.0 12.5 13.0 FZD7 FzE3 ENSG00000155760 "Frizzled class receptor 7" O75084 2 202033855-202038441 "G-protein coupled receptors, Human disease related genes, Predicted membrane proteins" "Wnt signaling pathway" "Developmental protein, G-protein coupled receptor, Receptor, Transducer" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Breast glandular cells: 30.9;Breast myoepithelial cells: 37.0;Cardiomyocytes: 21.1;Fibroblasts: 23.5;Proximal enterocytes: 21.3" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebellum: 30.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ: 42.8;BJ hTERT+: 48.4;CAPAN-2: 62.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA059979, HPA069165, HPA076183" Approved Supported Vesicles NA NA "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 35: Glandular cells - Unknown function" Vesicles "HPA059979: , HPA069165: AB_2686096, HPA076183: " "unprognostic (3.44e-2)" "unprognostic (6.89e-2)" "unprognostic (9.30e-3)" "unprognostic (2.44e-3)" "unprognostic (4.92e-2)" "unprognostic (1.02e-1)" "prognostic unfavorable (7.71e-5)" "unprognostic (1.40e-1)" "unprognostic (4.92e-2)" "unprognostic (8.22e-2)" "unprognostic (2.73e-2)" "unprognostic (1.10e-1)" "unprognostic (1.87e-3)" "unprognostic (8.16e-3)" "unprognostic (1.43e-1)" "unprognostic (4.16e-2)" "unprognostic (2.05e-3)" 10.2 3.0 4.9 5.6 4.7 0.4 15.5 30.2 4.3 13.2 6.3 36.7 6.9 18.4 14.1 9.4 16.8 6.3 14.4 8.8 5.0 8.2 1.2 5.3 3.9 5.2 4.9 25.0 1.7 1.1 9.3 5.7 5.5 19.2 5.5 1.3 21.7 23.5 26.7 10.9 10.8 11.1 4.9 1.9 5.9 2.1 4.5 1.1 5.1 9.5 3.8 27.1 15.3 5.6 10.3 5.2 33.2 10.8 10.6 7.9 14.8 42.8 48.4 11.9 13.9 32.2 62.7 0.1 25.1 26.2 7.9 10.6 6.0 1.3 13.7 5.4 8.6 1.1 2.1 2.7 7.2 2.1 2.1 7.6 1.0 6.4 3.7 9.5 0.0 0.7 2.9 2.6 9.8 4.2 0.0 5.7 36.6 2.0 3.5 4.2 6.4 1.1 1.9 6.1 5.5 12.6 5.4 0.4 6.8 26.7 3.8 2.5 0.1 23.8 8.8 15.0 5.4 2.7 2.2 0.1 4.9 0.5 16.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.9 4.7 30.2 4.3 8.8 5.0 5.2 4.9 5.5 4.9 4.5 5.6 3.5 0.0 8.1 3.6 2.0 10.3 8.3 1.9 14.8 0.0 30.9 37.0 21.1 1.5 0.3 1.8 0.0 0.5 2.0 4.7 1.9 1.6 0.1 1.5 2.0 1.7 1.2 0.0 1.5 0.2 1.1 23.5 2.6 3.6 1.3 7.5 0.7 0.7 1.5 0.0 0.2 9.9 0.0 0.8 5.7 0.5 5.3 2.0 3.6 0.0 0.1 7.5 0.0 0.0 0.1 0.6 2.1 4.9 1.7 6.9 21.3 0.1 0.9 0.6 6.6 13.5 16.3 1.6 2.9 11.4 9.8 0.8 2.5 0.5 7.6 1.8 GALNT12 GalNAc-T12 ENSG00000119514 "Polypeptide N-acetylgalactosaminyltransferase 12" Q8IXK2 9 98807670-98850081 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "epididymis: 74.7;intestine: 55.8;stomach 1: 54.8" "Cell type enhanced" "Detected in many" "Distal enterocytes: 101.2;Intestinal goblet cells: 142.4;Undifferentiated cells: 42.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "OE19: 128.4;U-2197: 160.9" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" "HPA048292, HPA071076" Enhanced Approved "Nucleoplasm,Plasma membrane,Cell Junctions" "Intracellular and membrane" NA NA 47000 "Cluster 48: NK-cells - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 18: U-2197 - ECM organization" "Cluster 27: Mucus-secreting cells - Mucin production" "Plasma membrane" "Nucleoplasm, Cell Junctions" "HPA048292: AB_2680343, HPA071076: " "unprognostic (7.85e-3)" "unprognostic (1.50e-1)" "unprognostic (2.33e-1)" "unprognostic (1.47e-2)" "unprognostic (2.97e-3)" "unprognostic (4.10e-2)" "unprognostic (1.06e-1)" "unprognostic (1.03e-1)" "unprognostic (2.03e-2)" "unprognostic (1.97e-1)" "unprognostic (2.61e-2)" "unprognostic (7.71e-2)" "prognostic favorable (3.24e-4)" "unprognostic (9.05e-2)" "unprognostic (1.92e-1)" "unprognostic (1.60e-3)" "unprognostic (6.87e-2)" 5.0 2.0 1.2 7.7 1.3 2.2 3.4 6.5 1.8 8.7 4.3 55.3 34.2 3.7 74.7 19.6 7.5 10.5 1.2 1.1 1.4 4.8 0.4 11.7 3.2 2.6 1.4 0.4 13.6 6.3 3.4 2.6 2.7 4.6 55.8 0.6 25.5 4.3 1.3 3.4 27.1 14.0 1.1 2.2 54.8 4.6 1.5 3.3 14.7 0.6 6.1 11.9 4.6 1.6 5.4 4.1 3.4 13.5 10.0 7.8 0.0 1.4 2.1 2.0 4.6 0.8 21.6 0.0 5.0 0.9 12.2 38.0 2.9 1.3 1.6 26.2 1.7 2.4 0.2 0.0 0.5 1.6 0.5 3.8 0.9 6.4 0.0 2.7 2.3 19.3 30.2 0.0 0.6 13.9 2.6 4.7 16.7 128.4 5.6 6.5 0.3 0.1 2.3 7.7 12.4 1.1 0.5 30.6 3.0 7.7 4.5 4.5 4.3 0.0 0.3 160.9 0.0 2.1 4.8 2.3 37.1 0.0 0.9 0.0 0.0 0.5 0.3 0.0 0.6 0.0 0.4 0.2 0.0 0.1 0.6 0.3 0.0 0.6 0.0 0.1 0.0 0.1 1.2 1.3 6.5 1.8 1.1 1.4 2.6 1.4 2.7 1.1 1.5 1.6 1.3 3.2 25.7 2.0 2.3 2.4 1.3 8.3 1.2 2.4 0.4 0.1 1.0 18.6 16.9 11.0 16.7 1.0 2.6 101.2 0.0 11.2 1.8 4.8 1.6 1.6 19.9 1.3 7.4 25.4 1.7 12.5 32.1 8.7 2.5 2.4 0.0 0.0 2.3 0.0 5.7 142.4 2.0 0.3 3.9 1.4 2.1 3.9 0.0 3.7 0.2 0.8 3.1 3.5 7.0 32.0 36.5 7.5 1.7 7.4 21.9 2.7 16.9 0.2 0.0 0.7 1.5 5.9 10.5 9.9 1.3 1.1 4.5 5.1 42.5 11.1 GNA12 gep ENSG00000146535 "G protein subunit alpha 12" Q03113 7 2728105-2844308 "Human disease related genes, Predicted intracellular proteins" Transducer "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 53.2" "Cell type enhanced" "Detected in many" "Oligodendrocyte precursor cells: 68.3;Syncytiotrophoblasts: 173.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB010046 Approved Supported Cytosol NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 70: Brain - Nervous system development" "Cluster 44: HDLM-2 - Immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Cytosol "CAB010046: AB_2263416" "unprognostic (1.21e-1)" "unprognostic (1.19e-2)" "unprognostic (9.28e-2)" "unprognostic (1.54e-1)" "unprognostic (2.14e-2)" "unprognostic (1.27e-3)" "prognostic unfavorable (1.20e-6)" "unprognostic (1.38e-2)" "unprognostic (1.48e-1)" "unprognostic (1.36e-2)" "unprognostic (4.45e-3)" "unprognostic (7.90e-2)" "prognostic unfavorable (4.71e-5)" "unprognostic (1.22e-2)" "unprognostic (2.52e-1)" "unprognostic (1.72e-1)" "prognostic unfavorable (2.27e-4)" 17.8 14.9 42.5 11.2 47.1 11.0 12.2 38.4 35.8 12.9 18.3 16.6 5.1 17.0 4.7 7.7 12.9 9.4 17.9 36.1 39.6 8.6 9.3 12.8 12.8 53.2 43.9 18.2 11.9 8.0 12.3 24.4 42.5 9.5 6.1 3.0 8.0 11.4 6.7 5.0 11.3 13.6 46.2 10.6 11.6 10.1 52.6 5.6 6.7 7.3 10.1 16.6 9.2 42.3 35.5 19.1 19.4 29.2 30.4 24.1 53.5 29.1 33.7 30.9 35.3 18.4 24.5 7.5 19.4 34.6 64.7 15.6 13.5 30.1 20.9 89.9 13.5 15.3 9.9 19.6 35.4 2.5 13.1 23.5 16.1 36.3 24.4 31.8 33.3 10.6 17.3 23.0 28.1 16.8 4.1 14.1 27.3 9.1 32.9 26.8 22.4 15.2 11.4 23.8 15.4 22.3 16.4 24.4 12.2 27.6 13.6 20.9 39.5 33.6 39.9 33.2 48.6 16.1 20.3 6.8 36.1 22.5 33.7 1.4 0.5 0.1 0.2 1.3 0.3 1.0 0.5 0.3 0.4 1.7 0.5 0.0 0.1 0.0 0.3 1.8 0.7 0.4 42.5 47.1 38.4 35.8 36.1 39.6 53.2 43.9 42.5 46.2 52.6 42.3 21.8 6.4 11.7 41.8 22.0 7.0 3.8 5.4 0.6 6.0 14.5 10.4 16.3 10.0 6.1 1.8 12.5 63.7 16.6 8.0 3.9 7.9 13.3 9.3 21.8 16.7 7.8 9.5 31.9 10.2 17.0 19.6 10.2 10.8 0.0 13.9 19.2 13.5 25.4 8.4 36.0 5.5 6.1 21.6 63.5 13.6 17.1 25.8 21.4 22.5 21.7 16.1 7.2 68.3 29.9 13.2 4.0 18.8 7.3 8.4 4.7 7.1 5.8 10.7 0.0 16.8 17.3 8.6 9.4 1.2 3.7 173.2 6.2 23.7 5.3 3.2 GNA13 "G13, MGC46138" ENSG00000120063 "G protein subunit alpha 13" Q14344 17 65009289-65056740 "Cancer-related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" Transducer "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 144.5" "Cell type enriched" "Detected in all" 4 "Langerhans cells: 537.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA010087 Approved Supported Cytosol NA NA 320000 "Cluster 7: Monocytes - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 41: Macrophages - Immune response" Cytosol "HPA010087: AB_10601478" "unprognostic (2.55e-1)" "unprognostic (2.27e-1)" "unprognostic (1.33e-3)" "unprognostic (1.23e-3)" "unprognostic (8.21e-2)" "unprognostic (7.05e-2)" "unprognostic (4.22e-3)" "unprognostic (1.09e-1)" "unprognostic (7.77e-2)" "unprognostic (4.66e-1)" "unprognostic (1.16e-2)" "unprognostic (1.94e-1)" "unprognostic (1.18e-1)" "unprognostic (1.18e-1)" "unprognostic (1.21e-1)" "unprognostic (1.44e-1)" "unprognostic (1.59e-1)" 23.7 22.5 21.3 41.5 23.9 144.5 15.8 25.0 22.5 17.6 21.3 27.7 21.0 17.9 10.5 18.2 15.9 26.5 12.6 20.2 26.6 17.6 27.0 27.1 46.8 26.9 21.7 22.6 15.3 15.8 8.3 39.3 30.1 15.1 26.2 17.2 10.4 16.1 36.8 12.1 23.3 22.9 25.4 33.5 18.0 15.4 23.7 49.9 17.9 38.6 44.6 30.5 12.3 35.2 33.3 36.9 32.6 21.6 31.8 29.5 32.2 25.3 28.7 35.0 39.7 20.7 23.0 130.0 16.1 26.6 42.0 22.5 35.0 29.4 51.5 35.4 19.5 69.0 20.7 38.7 45.7 54.2 45.5 23.9 43.8 32.2 42.0 29.1 48.6 33.6 29.7 82.3 36.9 29.3 88.9 18.8 19.4 30.2 25.7 49.0 64.8 47.2 32.0 53.3 24.5 48.8 19.7 34.8 43.8 62.1 40.7 50.0 37.9 58.4 48.8 25.0 33.2 57.3 79.4 151.4 20.1 32.2 30.4 7.3 6.0 7.6 5.6 12.5 5.7 4.5 6.8 6.8 5.2 4.0 3.9 4.4 13.8 6.8 8.5 2.1 9.7 4.0 21.3 23.9 25.0 22.5 20.2 26.6 26.9 21.7 30.1 25.4 23.7 35.2 34.5 12.8 13.0 68.9 80.9 67.8 27.8 13.1 42.1 5.3 21.0 13.0 11.7 18.6 10.1 9.2 4.2 16.6 60.5 82.2 7.9 11.8 4.5 25.3 23.6 35.4 16.8 21.2 20.7 11.6 15.1 24.3 23.9 49.9 30.4 21.9 32.5 13.8 57.4 6.7 27.3 11.6 12.2 57.9 537.6 8.0 11.5 123.8 69.4 44.0 44.1 34.4 29.9 29.1 36.7 13.4 30.7 24.0 45.9 28.3 23.5 16.4 13.8 6.1 32.9 19.2 19.9 6.7 13.6 33.7 65.9 14.0 66.5 15.4 13.7 36.2 GNAI2 "GIP, GNAI2B" ENSG00000114353 "G protein subunit alpha i2" P04899 3 50226292-50259362 "Human disease related genes, Predicted intracellular proteins" "Cell cycle, Cell division" Transducer "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Adipocytes: 656.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007704 Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA 4000000 "Cluster 52: Eosinophils - Transcription" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 7: Non-specific - Mitochondria" Cytosol "Nucleoplasm, Plasma membrane" "HPA007704: AB_1849230" "prognostic favorable (1.03e-4)" "unprognostic (3.89e-1)" "unprognostic (3.35e-2)" "unprognostic (8.40e-3)" "unprognostic (2.58e-1)" "unprognostic (2.32e-2)" "unprognostic (2.59e-2)" "unprognostic (3.23e-1)" "unprognostic (1.08e-3)" "unprognostic (6.01e-2)" "unprognostic (7.00e-3)" "unprognostic (1.12e-1)" "unprognostic (6.24e-3)" "unprognostic (1.44e-1)" "unprognostic (4.30e-2)" "unprognostic (4.33e-2)" "unprognostic (1.38e-1)" 210.2 100.3 155.2 217.9 167.3 367.1 152.8 166.3 181.6 146.0 120.2 142.1 69.9 141.7 66.9 124.4 136.9 152.5 157.1 144.3 184.6 79.4 126.5 214.5 251.3 199.8 170.2 147.7 64.1 66.9 99.2 241.8 194.8 103.6 64.3 35.6 71.9 156.9 69.3 87.0 103.0 154.0 173.6 262.1 73.6 69.6 173.3 160.3 101.3 89.4 170.4 169.7 108.4 193.2 128.2 63.0 186.3 197.6 220.7 277.5 35.5 271.1 399.6 354.9 361.1 70.4 173.2 149.1 119.2 567.0 193.4 100.1 132.8 350.3 222.8 331.2 50.9 364.8 158.0 110.2 219.8 329.2 479.8 270.3 152.9 319.1 129.8 289.6 837.8 124.1 26.1 307.1 357.5 155.7 313.6 433.0 109.7 59.0 302.4 185.0 89.8 219.7 232.6 130.9 48.4 86.1 189.5 57.1 124.4 150.4 94.3 346.1 792.3 330.9 187.5 309.2 274.7 199.4 278.3 127.0 373.6 466.9 398.1 16.6 59.3 113.7 33.7 80.9 20.2 28.8 26.8 34.3 57.3 26.1 20.2 25.8 145.2 23.5 74.5 47.2 34.0 27.3 155.2 167.3 166.3 181.6 144.3 184.6 199.8 170.2 194.8 173.6 173.3 193.2 656.8 41.7 32.1 25.1 119.5 56.7 59.7 32.3 45.5 29.0 61.6 83.8 22.9 55.8 26.6 44.1 14.6 79.5 311.4 11.7 5.9 124.3 203.3 57.8 115.7 340.3 92.2 52.1 12.4 60.5 84.4 101.9 21.9 71.8 89.9 150.0 221.3 79.7 336.0 6.7 14.8 24.6 18.3 342.7 291.7 302.0 90.7 386.1 83.6 58.1 356.6 292.6 151.4 26.7 45.4 160.3 40.9 95.5 104.8 46.1 30.3 24.5 24.4 21.9 52.6 85.3 163.1 16.6 22.6 37.6 62.9 116.4 164.9 156.3 20.5 70.1 GSTP1 "FAEES3, GST3, GSTP" ENSG00000084207 "Glutathione S-transferase pi 1" P09211 11 67583742-67586656 "Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "esophagus: 2087.9" "Cell type enhanced" "Detected in all" "Squamous epithelial cells: 4033.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "hTCEpi: 4998.3;OE19: 7810.3" "Low region specificity" "Detected in all" "HPA019779, HPA019869" Enhanced Supported Mitochondria,Cytosol No No 69000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 21: OE19 - Mitochondria" "Cluster 61: Squamous epithelial cells - Keratinization" "Mitochondria, Cytosol" "HPA019779: AB_1849799, HPA019869: AB_1849801" "unprognostic (9.81e-2)" "unprognostic (6.52e-2)" "unprognostic (7.24e-2)" "unprognostic (2.72e-2)" "unprognostic (1.06e-2)" "unprognostic (1.30e-3)" "unprognostic (3.27e-1)" "unprognostic (4.98e-2)" "unprognostic (1.28e-1)" "unprognostic (5.16e-3)" "unprognostic (2.14e-3)" "unprognostic (9.37e-2)" "unprognostic (5.72e-2)" "unprognostic (7.78e-2)" "unprognostic (2.23e-1)" "unprognostic (6.72e-3)" "unprognostic (1.48e-1)" 290.5 276.2 346.8 232.1 370.3 601.3 288.7 358.9 425.7 641.9 695.8 329.6 394.6 331.9 280.3 2087.9 647.5 435.8 367.2 341.4 381.9 567.7 45.1 468.3 321.8 375.7 379.2 306.9 340.9 737.4 320.2 326.9 378.5 291.7 197.1 137.9 541.2 780.4 355.0 731.4 321.7 214.2 367.0 257.2 535.5 45.8 378.1 296.9 579.0 312.5 380.8 526.5 946.2 377.7 1202.5 1599.4 763.7 1198.9 577.8 645.2 705.3 511.3 678.1 761.2 589.3 2956.3 1225.0 3.3 1144.7 813.5 683.7 1707.8 2073.9 2248.5 214.4 848.0 765.3 59.9 1107.6 0.5 852.2 400.3 667.6 807.2 4998.3 609.9 583.3 560.9 1160.2 847.2 1318.2 321.8 605.7 4.3 918.2 1100.6 1475.2 7810.3 681.3 844.8 129.6 3.8 1236.8 3.6 260.6 754.3 719.1 230.9 2394.0 598.2 3.6 656.3 634.5 351.6 883.8 740.6 378.6 200.0 1353.9 447.1 400.0 652.4 747.8 56.0 3145.4 246.6 720.0 2470.8 271.9 509.2 322.4 597.7 3582.7 476.3 267.8 466.5 130.5 1443.8 1608.5 1435.1 363.3 3948.4 346.8 370.3 358.9 425.7 341.4 381.9 375.7 379.2 378.5 367.0 378.1 377.7 466.7 1153.8 872.3 25.5 296.8 865.6 1914.8 3813.8 767.2 170.0 628.7 838.3 297.3 987.9 2763.5 1230.4 33.3 2116.8 372.4 655.0 1805.9 1811.9 4.9 1381.0 589.0 431.4 368.2 166.3 6.8 1444.4 1703.9 710.5 781.9 1020.9 269.9 795.0 382.3 10.5 861.2 70.7 10.1 992.4 1930.7 597.9 1090.3 25.5 572.3 703.5 1531.5 27.2 2166.5 558.5 459.3 17.6 38.4 1412.1 948.9 400.2 591.6 2266.2 844.4 3495.5 3715.4 274.4 361.6 401.3 941.7 4.8 54.9 4033.7 1061.7 1645.5 342.5 527.8 1118.5 3418.6 HGF "DFNB39, F-TCF, HGFB, HPTA, SF" ENSG00000019991 "Hepatocyte growth factor" P14210 7 81699010-81770438 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins, RAS pathway related proteins" "Growth factor, Serine protease homolog" "Cancer-related genes, Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 10 "placenta: 311.9" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 23.8;Fibroblasts: 95.8;Hepatic stellate cells: 25.0;Muller glia cells: 36.2;Smooth muscle cells: 26.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "basophil: 94.0" "Lineage enriched" "Detected in many" 5 "granulocytes: 94.0" "Cell line enhanced" "Detected in some" "ASC TERT1: 171.6;HHSteC: 135.8;HL-60: 82.4;hTEC/SVTERT24-B: 87.4;Karpas-707: 240.7;U-87 MG: 62.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "CAB010333, HPA040360, HPA044088" Approved "Secreted to blood" NA NA 4110000 14000 "Cluster 10: Basophils - Unknown function" "Cluster 28: Placenta - Pregnancy" "Cluster 2: Karpas-707 - Immune response" "Cluster 33: Fibroblasts - ECM organization" "CAB010333: AB_647965, HPA040360: AB_2676939, HPA044088: AB_2678804" "unprognostic (5.24e-2)" "unprognostic (6.77e-2)" "unprognostic (1.72e-2)" "unprognostic (5.12e-2)" "unprognostic (1.85e-2)" "unprognostic (7.45e-5)" "unprognostic (1.66e-1)" "unprognostic (9.28e-3)" "unprognostic (3.28e-2)" "unprognostic (2.97e-2)" "unprognostic (2.74e-1)" "unprognostic (5.29e-2)" "prognostic unfavorable (5.59e-4)" "unprognostic (7.90e-3)" "unprognostic (2.92e-2)" "unprognostic (1.14e-2)" "unprognostic (2.06e-2)" 7.9 19.8 1.6 6.3 3.3 12.3 5.2 1.5 7.8 7.2 1.8 4.4 2.6 8.1 3.6 2.9 5.4 16.6 4.7 2.9 3.6 11.8 30.3 19.5 2.2 3.6 2.3 1.8 2.1 2.1 2.4 311.9 4.3 7.2 3.4 14.2 2.4 6.4 0.8 0.9 2.3 7.1 1.8 6.5 3.9 2.4 2.9 1.5 5.6 3.9 1.5 10.4 6.3 3.3 0.0 0.0 0.1 0.0 21.6 171.6 0.1 0.7 33.4 0.1 0.1 0.0 0.0 0.0 0.0 0.8 0.2 0.2 0.0 0.0 0.0 0.0 0.1 6.0 0.0 0.0 135.8 82.4 0.4 41.4 0.0 87.4 0.3 0.0 2.2 0.0 0.1 240.7 0.6 0.0 0.0 56.4 0.0 0.0 0.2 0.8 0.0 7.5 0.0 0.0 0.2 9.3 0.0 0.1 0.0 0.2 0.0 3.5 0.4 2.0 0.0 0.1 0.0 0.1 0.0 0.0 62.6 16.9 0.1 94.0 15.2 3.9 0.0 18.7 0.0 0.0 0.0 0.0 4.8 0.0 0.0 0.0 3.2 0.0 17.3 1.0 0.0 4.3 1.6 3.3 1.5 7.8 2.9 3.6 3.6 2.3 4.3 1.8 2.9 3.3 6.2 0.0 4.1 16.3 0.0 1.0 0.2 0.0 1.8 0.2 0.3 0.5 1.3 1.5 0.6 0.0 0.0 5.6 0.0 0.0 0.0 0.0 15.2 1.0 23.8 6.2 0.0 2.1 0.3 0.0 4.9 95.8 0.5 0.9 1.3 0.0 25.0 0.5 18.4 0.0 22.4 0.0 0.0 12.5 1.9 2.3 18.3 14.0 1.8 7.5 10.5 36.2 1.0 0.0 0.1 0.0 0.0 10.9 0.3 0.4 0.0 0.0 0.0 0.7 13.1 0.9 26.2 0.2 0.3 0.3 0.1 12.0 0.6 1.3 0.0 0.4 HIF1A "bHLHe78, HIF-1alpha, HIF1, MOP1, PASD8" ENSG00000100644 "Hypoxia inducible factor 1 subunit alpha" Q16665 14 61695513-61748259 "Cancer-related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 448.3" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "eosinophil: 155.0" "Lineage enriched" "Detected in all" 7 "granulocytes: 155.0" "Cell line enhanced" "Detected in many" "LHCN-M2: 941.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000907, HPA001275, CAB017442" Approved Enhanced "Nucleoplasm,Nuclear bodies" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "Nuclear bodies" "CAB017442: AB_10621732, HPA000907: AB_2666139, HPA001275: AB_1079057" "unprognostic (1.07e-2)" "unprognostic (1.13e-3)" "unprognostic (9.41e-2)" "unprognostic (1.07e-1)" "unprognostic (2.51e-2)" "unprognostic (1.90e-1)" "unprognostic (2.94e-3)" "unprognostic (3.40e-1)" "unprognostic (4.05e-1)" "unprognostic (1.39e-1)" "unprognostic (1.77e-2)" "unprognostic (8.39e-2)" "unprognostic (1.24e-1)" "unprognostic (3.23e-2)" "unprognostic (3.58e-1)" "unprognostic (7.35e-2)" "unprognostic (3.88e-2)" 64.9 133.7 22.1 146.6 24.0 448.3 36.2 28.2 26.1 132.9 24.7 42.8 33.6 52.4 74.8 62.1 41.1 145.4 36.5 21.1 28.4 104.2 51.6 75.7 71.4 29.7 29.7 35.3 36.0 91.7 30.7 77.6 33.3 46.9 41.7 35.5 45.3 67.2 12.1 34.2 37.3 59.1 27.2 72.4 37.6 32.4 38.5 55.8 49.5 17.6 88.2 169.9 43.1 26.5 313.6 123.6 112.7 344.7 185.2 297.1 161.5 253.8 270.1 288.7 258.9 54.1 100.3 75.8 186.2 293.0 73.6 71.8 71.0 416.1 352.5 33.7 41.0 46.5 105.3 93.1 414.8 20.1 49.3 523.4 129.2 216.5 225.6 408.6 198.1 44.4 32.3 0.4 941.4 65.6 59.2 24.3 108.9 49.6 159.7 4.3 269.1 22.8 400.2 204.3 100.3 111.9 472.5 67.0 170.7 148.9 70.6 36.3 119.2 700.2 157.3 235.9 215.2 39.1 61.2 84.1 369.9 38.5 194.7 43.8 22.3 155.0 11.5 18.0 14.4 19.5 15.0 13.3 19.6 19.0 22.6 15.6 56.3 19.7 19.4 9.2 11.0 18.4 22.1 24.0 28.2 26.1 21.1 28.4 29.7 29.7 33.3 27.2 38.5 26.5 93.3 70.5 116.0 69.2 157.3 106.4 101.8 102.6 97.9 54.1 38.5 30.1 43.5 87.2 69.0 261.1 50.1 24.8 65.1 44.1 103.7 278.5 3.6 95.6 131.3 152.3 66.4 35.3 45.6 251.6 67.1 81.4 49.5 272.3 223.6 339.7 176.0 30.7 136.4 156.5 39.3 39.0 57.0 145.9 111.7 6.2 24.2 240.2 103.2 53.4 87.1 134.0 26.8 78.9 35.8 236.9 21.9 48.5 60.0 59.3 20.2 192.1 37.7 54.8 52.6 75.8 136.9 80.5 44.2 128.7 87.9 25.4 91.6 92.2 51.8 116.0 HLA-DRB5 ENSG00000198502 "Major histocompatibility complex, class II, DR beta 5" Q30154 6 32517353-32530287 "Human disease related genes, Predicted membrane proteins" "Adaptive immunity, Immunity" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lung: 356.2;lymphoid tissue: 423.3" "Cell type enriched" "Detected in many" 4 "Langerhans cells: 4068.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "myeloid DC: 61.9" "Group enriched" "Detected in all" 10 "B-cells: 26.1;dendritic cells: 61.9;monocytes: 35.2" "Cell line enhanced" "Detected in some" "HDLM-2: 641.1;HMC-1: 154.2;U-698: 189.9;U-87 MG: 238.6" HPA043151 Supported NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 44: HDLM-2 - Immune response" "Cluster 41: Macrophages - Immune response" "HPA043151: AB_2678342" "unprognostic (1.97e-3)" "unprognostic (4.74e-2)" "unprognostic (3.30e-2)" "prognostic favorable (7.89e-4)" "unprognostic (2.28e-2)" "unprognostic (4.68e-3)" "unprognostic (9.09e-3)" "unprognostic (2.08e-3)" "unprognostic (1.06e-2)" "unprognostic (5.40e-2)" "unprognostic (4.31e-2)" "unprognostic (2.87e-1)" "unprognostic (2.89e-2)" "unprognostic (1.45e-1)" "unprognostic (7.60e-3)" "unprognostic (9.72e-2)" "unprognostic (5.48e-2)" 110.0 63.0 1.0 138.9 1.4 23.0 82.6 0.9 4.2 53.8 2.9 70.1 13.1 39.7 109.8 48.6 61.0 2.5 48.0 0.9 1.9 66.6 42.6 356.2 423.3 1.2 1.3 25.4 27.9 0.0 27.2 6.6 0.9 32.6 52.9 3.0 27.6 0.0 22.3 47.9 184.7 0.2 2.3 228.4 214.2 11.8 3.2 165.8 46.1 0.0 162.8 56.2 28.9 2.0 0.2 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 3.4 0.0 0.0 0.7 0.0 0.0 0.0 641.1 6.2 0.0 0.0 0.0 0.0 0.6 154.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.6 0.0 0.2 0.2 1.3 0.0 0.0 0.0 3.3 0.0 0.0 0.0 0.0 0.1 0.3 0.4 0.0 6.6 0.0 0.0 56.0 0.1 3.3 0.8 1.9 0.4 41.4 0.8 189.9 238.6 1.8 0.1 0.2 28.6 3.8 0.9 35.2 0.1 23.0 0.8 2.4 61.9 26.1 0.1 1.1 0.7 2.1 20.3 13.3 4.1 51.9 1.0 1.4 0.9 4.2 0.9 1.9 1.2 1.3 0.9 2.3 3.2 2.0 467.2 16.0 84.9 0.0 632.7 104.3 3.1 9.3 23.9 0.6 9.9 15.2 9.5 88.6 35.6 14.7 4.2 1.4 140.9 17.5 1.9 2.8 2.7 1.5 1.1 285.3 1.8 72.3 0.1 8.1 2.9 30.3 75.4 2.0 60.1 1.5 88.5 3.4 475.2 0.0 0.1 35.4 12.2 516.2 4068.5 7.4 15.8 978.8 120.9 8.4 246.9 0.5 9.2 0.0 0.1 31.5 52.3 34.3 46.2 6.7 661.5 37.0 71.6 1.8 19.7 8.9 17.3 0.8 1.3 11.2 90.6 3.1 68.0 0.3 50.8 65.7 HRAS HRAS1 ENSG00000174775 "HRas proto-oncogene, GTPase" P01112 11 532242-537287 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" Hydrolase "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Suprabasal keratinocytes: 145.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "non-classical monocyte: 4.0" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002015, HPA049830, HPA070222" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 27: Brain & Skin - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Cytosol" "CAB002015: , HPA049830: AB_2680903, HPA070222: " "unprognostic (3.06e-2)" "unprognostic (2.98e-2)" "unprognostic (7.01e-2)" "unprognostic (3.08e-3)" "unprognostic (3.49e-3)" "unprognostic (3.87e-1)" "prognostic unfavorable (2.32e-4)" "unprognostic (1.07e-1)" "unprognostic (2.25e-1)" "unprognostic (1.50e-1)" "unprognostic (2.88e-3)" "unprognostic (9.85e-2)" "unprognostic (2.81e-1)" "unprognostic (1.85e-1)" "unprognostic (1.80e-1)" "unprognostic (1.58e-2)" "unprognostic (1.38e-1)" 28.1 24.6 64.6 3.5 67.2 2.9 27.0 62.1 86.8 30.4 58.3 34.3 2.8 23.6 12.5 80.1 18.9 3.6 56.8 64.4 64.6 33.8 21.8 27.1 4.3 65.6 65.3 20.0 20.5 13.1 38.2 9.0 66.9 38.3 6.9 10.2 27.3 12.3 59.0 69.9 19.5 8.9 64.2 20.6 24.2 16.5 64.8 9.2 20.5 25.2 10.2 34.5 44.2 65.4 59.0 105.6 44.2 25.6 22.2 17.5 39.6 49.9 25.1 64.5 29.5 62.4 29.7 20.4 10.9 63.2 60.7 43.7 46.0 114.1 19.3 19.5 108.4 6.6 43.7 56.1 38.5 13.9 12.0 28.3 118.0 42.0 51.5 19.6 31.5 34.3 29.7 32.3 40.9 110.6 34.0 50.5 26.5 39.9 94.5 31.6 40.7 18.2 47.0 33.2 87.6 43.7 25.5 55.4 17.9 31.5 43.3 14.8 35.4 47.3 44.7 16.4 39.7 20.3 17.7 15.4 39.1 17.0 38.3 0.0 0.5 0.6 0.8 0.7 0.4 0.3 0.9 0.8 0.7 2.0 0.9 0.3 0.0 0.1 4.0 0.9 1.5 0.2 64.6 67.2 62.1 86.8 64.4 64.6 65.6 65.3 66.9 64.2 64.8 65.4 51.3 12.8 10.7 9.1 18.0 131.2 101.7 25.4 82.0 46.0 38.8 75.7 25.2 22.8 11.2 35.0 18.8 78.8 21.5 72.2 74.3 35.2 1.6 36.1 28.6 32.0 29.3 11.2 9.8 37.4 63.4 25.9 33.6 34.1 2.5 26.8 22.9 17.4 39.9 48.8 10.6 26.5 4.1 11.7 38.4 7.9 17.1 21.3 64.0 10.3 12.8 50.8 11.3 4.0 12.3 48.2 30.9 23.0 26.5 61.2 30.8 54.6 20.0 37.6 32.9 20.3 40.3 5.4 21.4 118.1 145.9 78.1 22.0 18.8 26.2 106.4 IDH1 ENSG00000138413 "Isocitrate dehydrogenase (NADP(+)) 1" O75874 2 208236229-208266074 "Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Glyoxylate bypass, Tricarboxylic acid cycle" Oxidoreductase "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 536.3" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 320.2;Granulosa cells: 257.5;Hepatocytes: 328.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Hep G2: 768.1;RT4: 524.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033218, HPA035248, HPA057936, CAB062556" Enhanced Approved "Nuclear bodies,Cytosol" NA NA 16000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 40: Granulosa cells - Unknown function" "Nuclear bodies, Cytosol" "CAB033218: AB_2123166, CAB062556: AB_2665593, HPA035248: AB_10600714, HPA057936: AB_2683559" "unprognostic (2.79e-1)" "unprognostic (1.00e-1)" "unprognostic (1.02e-1)" "unprognostic (2.47e-3)" "unprognostic (1.93e-1)" "unprognostic (2.39e-2)" "prognostic unfavorable (6.93e-5)" "unprognostic (3.32e-1)" "unprognostic (2.20e-3)" "unprognostic (8.03e-2)" "unprognostic (5.54e-2)" "unprognostic (4.18e-3)" "prognostic unfavorable (2.45e-5)" "unprognostic (2.09e-1)" "unprognostic (1.77e-1)" "unprognostic (1.13e-1)" "unprognostic (2.69e-2)" 150.8 230.8 24.0 37.5 23.9 10.7 63.0 24.6 30.9 67.9 40.8 124.9 179.4 22.9 164.9 92.2 36.6 69.5 25.3 23.5 26.1 122.0 536.3 49.8 33.3 26.4 25.7 84.4 39.9 42.0 16.7 82.5 25.9 214.6 131.2 35.0 59.3 79.1 25.7 23.6 117.4 43.8 25.5 40.1 113.6 57.0 30.0 21.8 45.5 28.1 29.8 153.1 39.9 30.6 66.5 109.6 152.5 63.3 275.1 191.4 86.7 26.3 122.3 44.2 107.3 176.1 159.1 13.1 168.8 84.4 181.6 101.4 112.4 130.7 43.0 8.8 41.7 56.7 87.3 768.1 367.3 37.0 54.7 169.5 278.0 102.7 74.2 69.8 126.1 37.2 58.1 44.5 68.9 42.8 26.3 66.2 284.5 479.7 43.9 25.2 54.8 37.8 206.3 524.0 25.9 45.2 100.5 99.7 351.7 161.2 37.9 111.0 81.1 45.2 44.1 65.3 29.6 20.8 34.5 16.9 148.2 226.7 37.0 12.4 70.1 11.0 9.1 32.3 10.6 10.6 8.2 10.9 50.9 10.1 6.7 7.8 13.8 17.2 15.5 18.8 15.1 29.9 24.0 23.9 24.6 30.9 23.5 26.1 26.4 25.7 25.9 25.5 30.0 30.6 13.9 12.8 49.5 39.2 20.2 12.4 18.8 60.5 52.3 19.5 61.8 31.5 21.8 45.8 69.1 29.5 25.0 320.2 23.7 106.8 21.5 31.1 13.8 31.0 23.4 22.0 58.4 30.3 16.6 86.5 178.8 29.6 76.0 108.8 14.0 257.5 39.7 328.2 175.3 11.8 16.2 98.4 57.0 130.2 23.8 11.2 24.5 71.7 26.6 19.7 47.8 25.4 18.6 66.4 20.0 44.8 55.5 29.3 13.7 53.2 181.2 108.5 21.9 56.6 13.1 7.8 23.6 8.0 26.2 82.4 14.9 95.6 19.8 127.1 129.3 46.7 IDH2 ENSG00000182054 "Isocitrate dehydrogenase (NADP(+)) 2" P48735 15 90083045-90102477 "Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Glyoxylate bypass, Tricarboxylic acid cycle" Oxidoreductase "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 4 "heart muscle: 492.6;skeletal muscle: 1302.3;tongue: 1611.3" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 732.5;Distal tubular cells: 1168.0;Extravillous trophoblasts: 586.7;Syncytiotrophoblasts: 573.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MOLT-4: 425.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007831 Enhanced Supported Mitochondria NA NA 5200000 "Cluster 51: Monocytes - Innate immune response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 14: REH - Unknown function" "Cluster 47: Cytotrophoblasts - Unknown function" Mitochondria "HPA007831: AB_1851397" "unprognostic (2.45e-2)" "prognostic favorable (5.15e-5)" "unprognostic (2.92e-1)" "unprognostic (1.53e-1)" "unprognostic (3.53e-1)" "unprognostic (8.46e-2)" "unprognostic (3.83e-2)" "unprognostic (2.55e-3)" "unprognostic (1.86e-2)" "unprognostic (1.89e-2)" "unprognostic (2.76e-1)" "unprognostic (4.90e-2)" "unprognostic (2.19e-3)" "unprognostic (3.92e-3)" "unprognostic (4.46e-1)" "unprognostic (1.30e-2)" "unprognostic (2.58e-2)" 32.8 10.5 56.5 60.2 67.8 161.1 51.1 57.1 59.8 36.6 76.6 95.9 97.2 29.0 12.5 140.6 32.7 31.7 492.6 47.2 55.0 208.3 274.7 32.0 77.1 61.0 61.3 13.6 128.7 104.0 15.5 87.3 54.4 76.2 84.1 5.4 163.1 90.4 1302.3 61.8 84.3 79.8 52.9 36.8 175.7 5.3 71.6 148.7 16.0 1611.3 66.0 53.3 49.4 57.6 61.3 33.5 169.9 169.8 23.3 28.3 144.5 74.5 110.8 68.0 72.6 16.1 51.1 72.7 21.0 61.2 65.1 20.8 25.1 22.4 32.0 143.8 16.9 122.9 12.7 119.7 28.1 85.1 118.2 59.7 12.7 16.3 13.0 82.1 141.0 246.4 18.9 59.3 53.0 175.3 425.0 131.2 51.8 81.9 14.3 352.0 122.4 213.7 105.6 71.3 244.5 125.3 92.1 359.8 29.9 94.2 290.9 256.9 34.0 120.4 17.0 16.1 34.9 101.5 20.5 9.0 38.4 175.0 71.2 45.0 112.8 75.6 105.9 199.1 53.2 70.1 77.0 120.1 136.9 47.7 42.9 71.8 22.9 99.9 252.1 79.4 72.4 163.4 56.5 67.8 57.1 59.8 47.2 55.0 61.0 61.3 54.4 52.9 71.6 57.6 16.9 6.4 21.0 40.1 64.2 39.9 98.8 91.6 12.5 6.2 90.5 48.1 445.9 114.4 95.8 75.4 10.4 732.5 84.0 70.0 1168.0 252.8 5.6 96.4 25.7 41.6 61.7 193.8 11.8 288.8 586.7 44.7 88.2 50.9 31.6 29.2 38.2 283.1 263.7 10.1 8.3 158.3 229.9 77.7 101.1 3.2 14.0 79.0 58.7 5.6 85.3 20.9 119.4 16.6 27.3 116.6 105.0 35.3 185.9 170.3 69.6 205.0 167.9 5.4 13.1 60.8 73.4 0.6 15.6 113.3 67.1 573.0 88.1 14.7 305.1 140.1 IGF1 "IGF, IGF-I, IGF1A, IGFI" ENSG00000017427 "Insulin like growth factor 1" P05019 12 102395874-102481744 "Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins, RAS pathway related proteins" "Growth factor" Deafness "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 86.7;cervix: 89.0" "Group enriched" "Detected in many" 4 "Endometrial stromal cells: 1279.3;Leydig cells: 1103.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in single" "naive B-cell: 2.4" "Lineage enriched" "Detected in single" 24 "B-cells: 2.4" "Cell line enhanced" "Detected in some" "ASC diff: 37.9;HDLM-2: 49.6;K-562: 22.4;Karpas-707: 11.3;U-266/70: 13.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA048946 Approved "Secreted to blood" NA NA 103000000 330000000 "Cluster 24: B-cells - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 44: HDLM-2 - Immune response" "Cluster 36: Stromal cells - Cell proliferation" "HPA048946: AB_2680566" "unprognostic (1.25e-1)" "unprognostic (2.86e-3)" "unprognostic (1.46e-1)" "prognostic favorable (1.04e-4)" "unprognostic (1.52e-1)" "unprognostic (2.10e-1)" "unprognostic (1.59e-3)" "unprognostic (2.26e-1)" "unprognostic (9.98e-2)" "unprognostic (1.30e-1)" "unprognostic (1.59e-1)" "unprognostic (1.04e-2)" "unprognostic (2.34e-1)" "unprognostic (2.04e-2)" "unprognostic (1.55e-1)" "unprognostic (2.07e-1)" "unprognostic (1.11e-3)" 86.7 5.1 1.2 27.1 1.8 0.9 38.7 0.3 2.3 89.0 1.3 6.9 5.4 46.9 10.6 6.6 13.0 21.5 15.1 2.2 1.0 3.1 83.5 11.6 6.5 2.5 1.1 9.0 3.9 1.4 1.2 24.2 2.0 38.5 6.7 5.4 7.6 33.4 8.5 4.9 5.7 74.3 1.2 9.8 7.7 7.6 2.0 3.1 25.4 5.9 3.7 21.3 22.7 0.9 0.3 0.0 0.0 0.0 37.9 0.0 0.2 0.3 0.0 0.0 0.0 0.8 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 49.6 0.0 0.1 0.7 0.0 0.1 0.1 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.0 22.4 11.3 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 1.6 0.0 0.1 0.2 0.2 1.7 0.0 0.3 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 13.4 1.2 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 2.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 1.2 1.8 0.3 2.3 2.2 1.0 2.5 1.1 2.0 1.2 2.0 0.9 11.8 3.2 2.2 1.0 8.5 2.5 0.7 0.0 1.8 168.1 4.0 6.2 0.4 2.8 0.7 0.0 0.0 1.1 0.6 0.2 0.0 0.0 17.5 35.8 1279.3 38.9 0.0 5.3 1.2 0.6 1.5 259.7 2.6 34.5 0.0 0.3 6.4 243.0 122.0 0.0 123.9 0.0 16.2 25.8 12.5 58.0 1103.2 42.0 14.2 27.2 3.6 4.4 0.0 0.5 0.9 0.1 0.0 193.4 66.9 1.2 0.0 1.4 0.1 9.0 0.0 139.3 19.6 1.9 1.2 1.6 2.7 1.2 9.1 69.4 0.2 0.4 IGF1R "CD221, IGFIR, IGFR, JTK13, MGC18216" ENSG00000140443 "Insulin like growth factor 1 receptor" P08069 15 98648539-98964530 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Host-virus interaction" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 239.4;Inhibitory neurons: 194.6;Microglial cells: 245.4;Oligodendrocyte precursor cells: 237.7;Oligodendrocytes: 261.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 4.3" "Group enriched" "Detected in many" 6 "granulocytes: 4.3;T-cells: 1.4" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010268, HPA045563" Approved NA NA 46000 "Cluster 50: Neutrophils - Cellular senescence" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 20: HeLa - Mitochondria" "Cluster 40: Granulosa cells - Unknown function" "CAB010268: AB_671792, HPA045563: AB_2679368" "unprognostic (1.30e-3)" "unprognostic (5.81e-3)" "unprognostic (1.53e-1)" "unprognostic (3.34e-2)" "unprognostic (2.65e-1)" "unprognostic (2.05e-2)" "unprognostic (1.29e-2)" "unprognostic (6.87e-2)" "unprognostic (2.64e-2)" "unprognostic (2.87e-2)" "unprognostic (8.56e-2)" "unprognostic (1.62e-1)" "prognostic favorable (3.75e-7)" "unprognostic (1.57e-1)" "unprognostic (3.59e-1)" "unprognostic (1.41e-1)" "unprognostic (1.06e-1)" 7.3 11.3 10.1 3.6 11.2 11.0 12.2 12.0 12.0 10.1 35.5 12.5 2.5 11.0 11.1 7.5 13.0 4.5 9.6 9.5 8.2 11.6 0.9 9.5 2.7 12.4 13.4 15.8 15.4 2.1 8.8 12.1 11.2 14.7 4.5 16.0 10.0 9.6 7.0 11.1 6.5 6.1 10.3 5.8 9.6 8.4 13.2 6.1 12.9 11.6 3.4 9.9 10.0 11.1 6.1 34.0 22.6 0.2 11.9 8.3 16.3 8.0 14.5 2.5 2.2 15.6 17.5 1.6 22.1 13.8 14.7 31.6 10.9 25.0 1.9 0.1 11.1 27.5 32.3 31.2 10.4 11.1 2.5 12.1 14.9 4.5 18.6 9.3 8.4 2.8 1.4 5.4 9.9 48.1 5.4 9.8 23.0 11.8 1.3 7.7 19.3 6.7 7.4 37.8 8.1 35.9 56.0 3.3 30.1 50.2 16.7 3.8 24.5 1.5 26.5 6.5 12.0 1.9 9.8 5.9 4.6 10.0 5.9 1.9 0.3 0.9 0.4 0.2 0.2 0.1 0.3 0.1 0.1 0.4 1.4 0.4 4.3 0.5 0.3 0.1 0.0 0.3 10.1 11.2 12.0 12.0 9.5 8.2 12.4 13.4 11.2 10.3 13.2 11.1 30.8 28.9 13.4 157.7 3.5 32.8 28.8 31.1 35.3 51.5 58.3 33.4 30.8 5.7 30.2 22.0 91.8 33.7 8.0 10.7 1.9 16.6 27.6 79.7 39.6 26.1 35.0 7.8 239.4 11.2 20.3 25.2 11.2 91.3 0.0 106.5 52.5 1.5 6.5 75.7 194.6 21.1 20.3 6.6 8.3 53.4 18.0 8.3 21.4 245.4 8.5 45.6 14.4 237.7 261.0 29.1 12.9 13.5 4.3 70.9 5.3 21.8 55.4 36.1 0.0 20.4 27.6 4.0 17.2 17.9 32.0 27.5 6.4 20.9 24.5 51.5 IGF2 "C11orf43, FLJ44734, IGF-II" ENSG00000167244 "Insulin like growth factor 2" P01344 11 2129112-2141238 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" "Carbohydrate metabolism, Glucose metabolism, Osteogenesis" "Growth factor, Hormone, Mitogen" "Cancer-related genes, Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 9 "placenta: 2749.2" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 1104.3;Extravillous trophoblasts: 3196.3;Leydig cells: 3007.5;Peritubular cells: 643.9;Syncytiotrophoblasts: 1612.9" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebral cortex: 86.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CACO-2: 862.0;Hep G2: 600.5;LHCN-M2: 333.7;RH-30: 408.5;SH-SY5Y: 495.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007556, HPA007993" Enhanced Approved Nucleoplasm,Vesicles,Cytosol "Secreted to blood" NA NA 609000000 1200000000 "Cluster 28: Placenta - Pregnancy" "Cluster 39: CACO-2 - Unknown function" "Cluster 33: Fibroblasts - ECM organization" Vesicles "Nucleoplasm, Cytosol" "HPA007556: AB_2667860, HPA007993: AB_1851474" "unprognostic (1.54e-1)" "unprognostic (1.65e-2)" "unprognostic (1.31e-1)" "unprognostic (7.08e-2)" "unprognostic (2.30e-3)" "unprognostic (2.59e-1)" "prognostic favorable (7.12e-4)" "unprognostic (7.92e-2)" "unprognostic (2.59e-2)" "unprognostic (1.68e-2)" "unprognostic (3.69e-2)" "unprognostic (1.85e-1)" "unprognostic (1.79e-3)" "unprognostic (2.00e-2)" "unprognostic (8.98e-2)" "unprognostic (8.93e-3)" "unprognostic (5.78e-2)" 99.7 58.4 5.5 9.2 32.6 0.9 41.8 12.6 86.0 75.5 236.8 22.3 4.7 75.2 52.7 18.8 128.4 34.8 91.7 6.5 7.1 31.8 305.9 9.8 3.4 20.2 6.6 117.8 37.5 5.2 25.4 2749.2 10.1 14.5 4.8 0.5 11.6 15.2 82.1 8.4 10.9 14.7 13.0 14.4 11.9 23.7 10.9 3.4 12.4 114.0 4.7 24.2 23.6 9.0 0.0 2.8 0.3 0.6 0.2 0.3 1.8 112.8 1.3 3.6 0.4 862.0 0.4 0.1 8.4 0.0 2.1 0.1 0.9 7.0 7.9 0.1 0.5 0.2 0.2 600.5 143.4 0.7 0.0 174.7 0.5 0.7 0.2 0.1 1.4 0.0 0.3 0.0 333.7 2.2 0.1 0.8 1.2 0.2 1.5 0.1 408.5 0.9 0.0 0.9 32.7 495.6 0.7 0.1 0.0 83.0 4.2 0.0 0.4 0.2 20.1 0.2 0.0 0.1 0.0 0.2 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.5 32.6 12.6 86.0 6.5 7.1 20.2 6.6 10.1 13.0 10.9 9.0 40.6 3.2 3.1 0.0 2.6 5.4 0.5 0.5 0.6 0.4 0.0 0.0 6.5 8.6 0.9 3.7 0.0 1104.3 0.0 0.0 0.0 0.0 13.1 0.0 0.0 498.4 0.0 16.0 0.0 0.0 3196.3 334.2 0.0 0.0 0.0 0.0 171.4 494.9 218.2 0.0 0.0 0.0 0.0 11.6 5.5 91.1 3007.5 3.4 3.6 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 643.9 0.0 1.1 0.0 0.0 0.9 0.5 65.7 33.5 37.5 3.8 6.3 1.5 4.1 1612.9 1.8 0.0 0.0 0.4 JAK2 JTK10 ENSG00000096968 "Janus kinase 2" O60674 9 4984390-5129948 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Adaptive immunity, Immunity, Innate immunity" "Chromatin regulator, Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 93.4;Inhibitory neurons: 122.3;Microglial cells: 106.8;Oligodendrocyte precursor cells: 69.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 132.5" "Lineage enriched" "Detected in all" 5 "granulocytes: 132.5" "Group enriched" "Detected in many" 5 "ASC diff: 42.2;HDLM-2: 75.0;HEL: 154.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013089, HPA040820, HPA043870" Approved Supported "Nucleoplasm,Plasma membrane,Focal adhesion sites" No No "Cluster 46: Basophils - DNA binding" "Cluster 16: Immune cells - Immune response" "Cluster 36: HEL - Hemostasis" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "Plasma membrane, Focal adhesion sites" "CAB013089: AB_2533647, HPA040820: AB_2677151, HPA043870: AB_2678708" "unprognostic (2.24e-3)" "unprognostic (2.76e-2)" "unprognostic (1.50e-2)" "unprognostic (7.67e-2)" "unprognostic (5.50e-2)" "unprognostic (3.09e-2)" "unprognostic (1.48e-1)" "unprognostic (7.36e-2)" "unprognostic (1.09e-1)" "unprognostic (5.49e-3)" "unprognostic (1.58e-1)" "unprognostic (1.72e-2)" "unprognostic (3.85e-1)" "unprognostic (4.53e-2)" "unprognostic (3.43e-2)" "unprognostic (1.96e-1)" "unprognostic (7.37e-3)" 15.6 7.6 3.2 19.2 3.7 21.7 8.9 6.3 9.1 8.5 1.1 6.7 6.5 11.3 8.6 8.8 8.0 10.5 24.5 2.7 3.1 6.8 4.5 10.9 18.2 3.3 1.8 11.5 3.8 6.5 2.9 11.0 2.0 6.8 6.5 12.8 4.0 6.2 9.8 11.2 7.7 9.5 3.5 17.6 13.4 9.8 1.7 7.5 4.8 8.9 12.7 11.7 9.1 3.9 6.8 3.7 3.7 6.3 42.2 12.4 1.1 9.1 8.6 7.2 4.6 1.2 2.0 0.3 2.1 5.4 5.4 2.3 4.4 5.1 4.9 75.0 1.4 154.7 7.6 1.7 10.0 10.5 7.1 9.5 2.1 2.8 4.5 7.6 6.6 5.1 10.9 17.4 11.6 2.2 2.9 12.8 3.3 3.3 4.3 5.1 8.2 2.2 4.7 3.5 4.2 2.4 2.6 3.5 2.8 3.6 2.0 15.4 13.1 10.2 3.6 10.7 6.4 3.1 6.4 1.5 13.6 4.7 5.3 132.5 20.5 38.2 5.6 20.1 4.5 5.6 4.1 3.1 26.5 4.9 2.2 2.8 19.2 9.6 16.4 9.7 4.5 7.7 3.2 3.7 6.3 9.1 2.7 3.1 3.3 1.8 2.0 3.5 1.7 3.9 14.3 16.0 7.9 31.6 12.9 9.7 3.3 4.9 10.8 8.0 5.2 3.4 30.0 0.0 6.7 7.3 8.4 1.9 13.9 11.7 1.9 3.3 8.6 5.1 11.2 9.4 3.0 19.8 93.4 3.9 0.9 8.9 38.7 5.6 14.0 11.4 4.6 1.9 14.2 8.4 122.3 4.5 0.0 33.6 28.8 7.1 23.6 38.9 5.4 106.8 49.5 12.6 8.2 69.9 42.3 7.0 20.9 33.4 10.7 3.0 3.9 3.3 7.1 11.2 0.0 9.7 12.5 15.0 5.5 11.6 8.4 3.4 10.4 5.1 4.1 4.5 JUNB ENSG00000171223 "JunB proto-oncogene, AP-1 transcription factor subunit" P17275 19 12791486-12793315 "Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" DNA-binding "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 679.4" "Group enriched" "Detected in all" 5 "granulocytes: 679.4;monocytes: 182.7" "Cell line enhanced" "Detected in all" "HDLM-2: 629.0;U-266/70: 256.4;U-266/84: 411.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004464, HPA019149" Approved Supported Nucleoplasm NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 89: Fibroblasts - ECM organization" "Cluster 44: HDLM-2 - Immune response" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "CAB004464: AB_2130023, HPA019149: AB_1852053" "unprognostic (1.03e-2)" "unprognostic (1.10e-1)" "unprognostic (2.11e-1)" "unprognostic (1.04e-1)" "unprognostic (7.17e-2)" "unprognostic (1.77e-2)" "unprognostic (2.19e-1)" "unprognostic (2.13e-2)" "unprognostic (1.12e-1)" "prognostic unfavorable (3.65e-4)" "unprognostic (1.79e-1)" "unprognostic (9.78e-2)" "prognostic unfavorable (1.05e-4)" "unprognostic (7.20e-2)" "unprognostic (7.06e-2)" "unprognostic (3.77e-1)" "unprognostic (1.02e-1)" 722.8 259.5 22.9 110.3 28.0 455.2 248.5 90.1 65.2 283.3 30.4 287.0 52.8 130.1 2.2 449.1 874.8 92.6 383.5 28.3 68.8 184.2 279.0 399.2 65.0 83.5 29.8 649.5 150.0 20.8 351.9 39.4 33.6 195.0 22.0 32.0 131.6 56.1 144.6 605.9 145.0 58.1 51.5 153.3 309.8 30.0 31.3 78.8 198.7 73.3 12.9 333.0 330.6 34.8 52.9 10.4 2.8 6.4 11.3 27.4 10.2 22.8 19.2 11.0 10.0 6.8 30.4 18.2 77.4 8.4 33.5 98.5 2.5 34.3 1.2 629.0 9.9 18.0 42.2 9.0 15.1 24.3 80.5 34.9 97.6 10.0 7.5 22.0 5.3 12.9 48.1 32.6 3.6 158.8 16.8 147.5 1.7 36.1 40.0 22.4 7.7 38.8 7.5 65.5 23.7 36.0 98.4 59.5 30.5 1.7 10.5 27.0 17.6 32.2 18.7 64.3 28.9 256.4 411.4 17.1 37.7 62.7 8.9 29.1 132.2 132.2 33.4 182.7 33.4 30.6 36.8 42.0 87.1 25.4 25.5 28.5 679.4 18.6 177.2 7.9 38.7 124.1 22.9 28.0 90.1 65.2 28.3 68.8 83.5 29.8 33.6 51.5 31.3 34.8 3158.0 115.4 423.2 130.2 1751.7 1463.9 1778.3 2367.7 1985.1 81.0 1296.9 1693.1 374.0 474.7 707.4 154.5 39.6 129.7 1766.9 819.7 49.0 833.3 9.5 468.5 1091.4 1469.5 1502.1 244.8 8.7 546.7 224.7 2182.3 1060.1 627.8 510.5 310.0 852.4 84.6 1178.4 21.9 4.4 1029.3 740.6 674.1 2747.6 27.9 815.2 1583.3 894.6 20.6 379.3 634.6 115.4 4.5 2.4 1026.7 875.3 263.3 842.5 1036.7 701.0 84.2 337.3 168.8 1163.6 2566.6 2624.1 9.4 10.5 1164.3 1804.1 440.3 2362.6 417.0 687.7 472.6 KDM6A UTX ENSG00000147050 "Lysine demethylase 6A" O15550 X 44873188-45112779 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Chromatin regulator, Dioxygenase, Oxidoreductase" "Cancer-related genes, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Microglial cells: 116.2;Oligodendrocyte precursor cells: 118.1;Oligodendrocytes: 264.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000568, HPA001165, HPA002111" Enhanced Approved "Nucleoplasm,Nucleoli,Nucleoli rim" "Intracellular and membrane" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 3: HMC-1 - Innate immune response" "Cluster 44: Endometrium - Transcription" "Nucleoli, Nucleoli rim" Nucleoplasm "HPA000568: AB_1858705, HPA001165: AB_1080541, HPA002111: AB_1858704" "unprognostic (1.73e-3)" "unprognostic (6.86e-3)" "unprognostic (1.45e-2)" "unprognostic (1.36e-1)" "unprognostic (1.72e-1)" "unprognostic (2.65e-2)" "unprognostic (2.58e-3)" "unprognostic (8.22e-3)" "unprognostic (3.23e-1)" "unprognostic (2.44e-1)" "unprognostic (2.56e-1)" "unprognostic (1.07e-1)" "unprognostic (2.73e-1)" "unprognostic (2.24e-2)" "unprognostic (5.18e-2)" "unprognostic (1.26e-1)" "unprognostic (3.16e-2)" 9.6 8.0 6.7 4.5 7.6 19.4 10.6 7.2 10.6 15.7 6.5 9.1 6.2 14.0 5.1 11.1 14.0 3.4 6.6 6.8 6.9 6.8 10.4 10.8 8.0 7.3 6.8 17.2 10.8 6.4 8.6 3.9 7.3 7.7 4.1 3.8 10.5 3.1 10.4 18.4 13.0 4.1 7.1 14.1 12.5 12.2 7.0 12.9 9.4 6.1 5.3 9.8 15.2 9.9 7.3 5.8 7.0 9.3 5.0 6.8 15.7 4.9 4.2 4.0 4.1 10.4 5.2 4.6 3.2 3.5 10.1 13.9 6.5 5.4 3.9 7.6 10.8 2.4 4.5 5.2 3.7 2.6 13.2 2.6 6.4 8.2 6.6 5.1 4.2 5.3 6.4 10.1 2.4 6.0 6.9 13.6 6.8 4.2 7.4 6.4 7.1 1.4 3.8 9.2 6.2 4.4 18.2 6.8 10.7 14.1 8.5 0.0 3.0 5.4 5.2 5.2 3.6 5.5 8.8 5.6 4.0 3.3 3.3 7.3 1.7 1.5 1.9 3.5 2.1 1.9 2.5 2.8 3.1 1.2 2.5 2.4 2.8 2.8 3.0 1.7 2.2 2.0 6.7 7.6 7.2 10.6 6.8 6.9 7.3 6.8 7.3 7.1 7.0 9.9 23.2 6.4 10.6 92.1 26.0 26.1 14.3 9.4 38.1 7.7 16.8 12.1 12.8 12.8 10.9 7.3 14.6 4.5 26.1 24.6 0.0 8.4 1.5 26.4 25.5 13.1 13.1 16.8 88.3 7.5 7.9 14.2 23.0 39.7 2.5 27.3 6.4 17.6 7.0 25.2 74.0 14.0 6.1 9.1 13.8 2.0 6.5 19.9 10.6 116.2 12.6 6.8 6.2 118.1 264.6 9.1 17.4 7.2 31.4 14.2 22.6 3.7 8.9 9.7 6.6 20.9 17.0 14.1 12.5 29.3 26.3 10.9 27.4 10.6 13.1 17.1 KEAP1 "INrf2, KIAA0132, KLHL19, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454" ENSG00000079999 "Kelch like ECH associated protein 1" Q14145 19 10486125-10503558 "Cancer-related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 178.2" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005558, CAB025337" Approved Supported "Nucleoplasm,Centriolar satellite,Cytosol" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Centriolar satellite" Cytosol "CAB025337: , HPA005558: AB_1079175" "unprognostic (1.98e-1)" "prognostic favorable (3.28e-4)" "unprognostic (1.61e-1)" "unprognostic (1.02e-1)" "unprognostic (1.42e-1)" "unprognostic (1.63e-2)" "unprognostic (2.64e-2)" "unprognostic (1.46e-1)" "unprognostic (1.48e-1)" "unprognostic (5.22e-3)" "unprognostic (2.04e-1)" "unprognostic (9.99e-2)" "unprognostic (1.29e-1)" "unprognostic (7.71e-3)" "unprognostic (5.06e-1)" "unprognostic (8.18e-2)" "unprognostic (1.60e-2)" 31.3 41.2 54.8 20.5 61.6 20.4 30.3 61.8 60.9 32.7 49.7 37.6 26.5 31.3 22.2 55.4 28.9 24.3 60.7 53.2 59.4 32.5 60.9 25.3 23.2 61.4 60.5 25.3 32.8 24.3 30.0 17.0 60.3 36.8 16.5 16.4 34.7 24.9 178.2 38.7 27.5 18.7 58.8 32.2 33.2 20.5 59.6 23.0 35.6 75.7 18.5 41.4 36.3 68.4 58.0 102.8 27.2 35.1 55.8 45.4 30.3 48.1 35.9 46.6 41.6 73.7 54.2 82.9 122.9 53.3 34.8 49.7 55.6 36.9 23.7 78.3 61.7 126.3 29.9 87.9 54.5 65.4 63.9 50.0 51.0 53.5 25.1 39.1 46.3 23.7 79.1 135.4 41.6 79.9 46.1 177.8 80.8 54.2 88.6 84.6 34.8 95.1 30.4 67.4 75.3 40.4 66.8 42.4 42.1 23.9 37.8 82.3 56.5 72.9 41.0 86.0 57.0 86.8 113.0 81.1 58.0 78.5 56.0 36.4 37.9 41.4 55.3 33.8 53.1 26.3 38.5 52.0 45.4 11.7 23.6 33.7 20.9 42.5 34.6 31.4 50.2 41.8 54.8 61.6 61.8 60.9 53.2 59.4 61.4 60.5 60.3 58.8 59.6 68.4 18.3 28.9 20.8 5.5 13.8 21.9 24.4 40.3 27.9 21.5 15.7 11.4 24.0 21.5 25.4 11.0 8.4 27.3 11.6 33.2 13.7 32.8 27.5 13.4 17.1 27.8 26.9 45.2 5.3 36.3 25.2 23.5 18.8 13.3 12.0 22.8 35.3 34.4 29.0 26.9 5.9 21.4 40.7 15.1 13.4 43.9 29.2 16.1 10.6 3.7 41.8 43.0 7.2 11.6 18.3 29.8 27.1 25.9 26.6 33.3 36.8 24.9 17.2 13.9 13.1 17.7 22.4 21.2 16.6 34.7 22.0 26.8 20.1 29.6 31.5 24.8 KIF14 KIAA0042 ENSG00000118193 "Kinesin family member 14" Q15058 1 200551497-200620751 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Motor protein" "Ciliopathy, Disease variant, Meckel syndrome, Primary microcephaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 6.5;lymphoid tissue: 10.9" "Cell type enhanced" "Detected in many" "Erythroid cells: 27.1;Granulosa cells: 13.2;Spermatocytes: 22.8;Spermatogonia: 16.3" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "HPA038061, HPA058220" Uncertain Supported "Midbody ring,Cytosol" Yes Yes "Cluster 18: Basophils - Vesicular transport" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Cytosol "Midbody ring" "HPA038061: AB_10669515, HPA058220: AB_2683642" "unprognostic (1.84e-1)" "unprognostic (7.15e-2)" "unprognostic (2.00e-2)" "unprognostic (1.87e-2)" "unprognostic (2.74e-1)" "unprognostic (1.51e-1)" "unprognostic (1.18e-3)" "prognostic unfavorable (8.64e-4)" "unprognostic (8.47e-3)" "unprognostic (1.02e-1)" "unprognostic (2.54e-5)" "unprognostic (2.31e-2)" "unprognostic (0.00e+0)" "unprognostic (6.28e-3)" "unprognostic (3.31e-1)" "unprognostic (8.14e-2)" "unprognostic (7.44e-2)" 0.2 0.2 0.1 2.0 0.0 6.5 0.3 0.2 0.3 0.2 0.1 0.9 1.2 0.3 0.0 1.0 0.0 0.2 0.0 0.1 0.1 0.0 0.3 0.2 3.2 0.1 0.2 0.0 0.0 0.0 0.0 0.9 0.1 0.0 1.2 0.1 0.1 0.0 0.0 1.0 1.1 0.6 0.0 0.6 0.6 2.5 0.1 10.9 0.1 0.0 3.2 0.4 0.3 0.1 29.7 17.3 26.8 15.0 0.8 3.0 14.8 20.0 11.7 18.7 16.8 10.5 15.1 18.0 7.0 9.6 11.6 23.0 21.6 13.3 26.7 22.1 11.3 28.8 24.8 10.3 0.1 45.5 15.7 0.6 0.6 20.9 17.8 4.0 13.5 26.3 44.0 22.6 23.5 12.1 26.9 14.2 22.6 8.7 15.0 24.3 35.4 22.8 6.3 8.3 12.7 14.0 28.3 9.5 11.0 19.8 12.9 11.6 11.1 14.7 17.3 16.2 35.3 8.2 8.9 25.8 8.6 24.0 30.5 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.1 0.0 0.2 0.3 0.1 0.1 0.1 0.2 0.1 0.0 0.1 0.1 1.0 0.0 0.0 0.0 1.9 2.4 1.0 1.1 0.6 2.3 1.5 1.9 0.8 0.0 0.9 0.0 2.1 4.2 0.6 2.5 0.0 0.2 4.1 3.7 2.2 1.6 0.0 27.1 1.1 0.0 7.7 3.3 10.2 5.0 2.5 13.2 2.5 0.9 5.4 0.0 0.9 5.2 0.0 2.9 1.9 2.5 0.6 2.3 0.0 0.0 0.4 0.5 0.0 0.5 0.8 0.3 0.0 0.7 11.3 1.2 0.2 0.1 1.4 0.8 6.6 1.4 2.1 22.8 16.3 8.3 0.9 1.4 2.3 0.7 4.3 1.9 KIT "C-Kit, CD117, PBT, SCFR" ENSG00000157404 "KIT proto-oncogene, receptor tyrosine kinase" P10721 4 54657918-54740715 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, RAS pathway related proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "breast: 114.9" "Cell type enhanced" "Detected in many" "Breast glandular cells: 83.1;granulocytes: 529.3;Inhibitory neurons: 111.2;Ionocytes: 101.7;Melanocytes: 211.7" "Cancer enhanced" "Detected in many" "testis cancer: 28.6" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 7 "basophil: 20.3;eosinophil: 12.8;NK-cell: 13.1" "Group enriched" "Detected in many" 7 "granulocytes: 20.3;NK-cells: 13.1" "Group enriched" "Detected in many" 13 "HEL: 247.2;HMC-1: 496.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003288, HPA004471, CAB068253, CAB072867, HPA073252" Enhanced Supported Supported "Plasma membrane" NA NA 49000000 "Cluster 2: Granulocytes - Unknown function" "Cluster 5: Breast - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 60: Granulocytes - Receptor signaling" "Plasma membrane" "CAB003288: AB_2335702, CAB068253: AB_2665717, CAB072867: AB_2665718, HPA004471: AB_1078431, HPA073252: AB_2686589" "unprognostic (1.55e-2)" "unprognostic (1.91e-1)" "unprognostic (4.04e-2)" "unprognostic (8.19e-2)" "unprognostic (3.96e-2)" "unprognostic (2.18e-2)" "unprognostic (2.33e-2)" "unprognostic (1.97e-2)" "unprognostic (3.60e-2)" "unprognostic (1.64e-1)" "unprognostic (2.20e-1)" "unprognostic (1.92e-2)" "prognostic favorable (5.63e-4)" "unprognostic (1.34e-3)" "unprognostic (1.87e-1)" "unprognostic (1.29e-2)" "unprognostic (2.30e-1)" 6.6 1.8 8.2 5.3 6.3 6.4 114.9 21.4 6.5 17.6 5.1 13.5 9.2 9.6 5.9 13.0 2.9 20.3 3.4 23.9 5.1 12.4 0.8 21.8 3.4 6.8 12.3 45.0 2.6 1.7 1.9 10.0 8.8 5.6 16.0 3.2 21.4 8.7 1.1 24.5 13.4 10.1 5.9 5.0 17.4 6.2 16.7 3.1 47.1 6.9 6.2 14.5 4.9 5.1 0.0 0.0 3.9 0.0 0.7 0.3 0.0 3.3 4.6 12.6 15.8 0.0 0.0 0.0 0.0 7.3 0.6 0.3 2.6 0.0 10.8 0.0 5.9 247.2 0.0 0.0 0.0 0.0 496.2 0.0 0.0 0.0 0.0 0.0 28.4 4.3 3.5 0.5 0.0 0.0 1.4 2.5 6.9 0.0 0.0 0.8 0.0 0.0 0.0 24.2 6.0 2.1 0.0 0.0 0.0 14.1 0.0 2.6 0.3 0.5 0.0 4.9 0.1 0.4 0.0 0.0 0.5 0.9 0.6 20.3 0.0 12.8 0.1 0.0 2.3 0.0 0.4 0.9 2.3 0.0 0.0 0.0 1.0 13.1 1.4 0.1 0.0 0.2 8.2 6.3 21.4 6.5 23.9 5.1 6.8 12.3 8.8 5.9 16.7 5.1 7.3 6.4 21.9 9.8 1.0 14.3 0.9 0.4 2.2 4.5 83.1 59.2 0.7 4.3 3.6 3.7 0.0 0.1 5.2 0.4 3.9 1.0 0.0 0.2 0.7 9.2 5.4 15.5 0.9 0.0 0.1 2.8 8.6 0.7 529.3 0.5 1.8 0.0 0.3 0.0 111.2 0.5 101.7 0.3 4.2 0.4 1.2 1.6 211.7 14.0 0.2 2.4 0.0 16.1 3.7 0.0 0.1 0.0 3.2 0.5 0.0 0.8 0.1 0.2 0.0 0.7 0.8 0.1 12.3 2.2 3.8 0.3 8.8 63.7 0.6 0.3 KLF4 "EZF, GKLF" ENSG00000136826 "Kruppel like factor 4" O43474 9 107484852-107490482 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skin 1: 254.7" "Cell type enhanced" "Detected in many" "Adipocytes: 1054.7;Basal squamous epithelial cells: 832.1;Distal enterocytes: 789.2;Intestinal goblet cells: 710.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "intermediate monocyte: 1.0;non-classical monocyte: 1.0" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "ASC TERT1: 39.2;hTCEpi: 84.4;hTERT-HME1: 54.5;OE19: 47.2;U-2197: 111.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002926 Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 18: U-2197 - ECM organization" "Cluster 41: Macrophages - Immune response" Nucleoplasm Cytosol "HPA002926: AB_1852541" "unprognostic (2.06e-1)" "unprognostic (1.42e-2)" "unprognostic (1.14e-2)" "unprognostic (2.45e-1)" "unprognostic (1.55e-1)" "unprognostic (6.58e-3)" "unprognostic (3.44e-2)" "unprognostic (6.49e-2)" "unprognostic (3.45e-1)" "unprognostic (1.29e-2)" "unprognostic (1.18e-2)" "unprognostic (1.08e-1)" "prognostic favorable (3.93e-5)" "unprognostic (2.55e-1)" "unprognostic (1.67e-1)" "unprognostic (8.13e-2)" "unprognostic (8.32e-2)" 73.5 23.9 5.1 21.0 4.7 50.5 63.7 4.0 7.8 53.2 4.6 87.3 28.4 16.0 5.6 102.1 43.0 44.3 31.0 3.7 5.1 6.2 12.4 44.8 5.6 5.0 4.7 29.0 7.0 5.7 4.9 32.4 5.0 16.7 96.0 0.8 27.5 7.6 14.2 254.7 40.5 40.6 4.1 24.1 58.0 17.8 6.0 17.0 25.2 23.2 14.5 43.9 58.9 4.0 13.3 3.9 0.6 0.1 16.6 39.2 5.2 4.4 27.6 6.7 8.1 1.0 18.0 0.0 0.6 6.9 23.7 8.7 6.1 3.9 3.0 0.0 2.2 0.0 7.5 0.3 21.6 0.0 0.0 5.0 84.4 14.0 54.5 1.5 0.6 0.2 0.6 0.0 4.1 7.3 0.0 1.4 4.1 47.2 25.2 0.3 1.6 0.2 2.3 3.7 0.4 0.2 4.0 11.8 15.2 12.7 1.3 5.4 3.5 3.6 0.1 111.5 2.1 0.2 0.1 0.0 3.4 2.6 6.8 0.0 0.9 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.2 0.0 1.0 0.2 0.0 0.1 5.1 4.7 4.0 7.8 3.7 5.1 5.0 4.7 5.0 4.1 6.0 4.0 1054.7 12.8 41.1 0.3 32.2 436.0 284.3 143.0 832.1 0.5 206.7 205.0 70.3 35.8 71.5 1.8 8.4 49.1 15.0 789.2 1.9 24.4 263.1 154.1 216.0 336.6 123.8 4.8 0.0 38.7 75.5 463.2 537.2 297.4 54.7 4.7 216.0 4.6 89.9 0.0 0.2 710.9 83.4 232.9 282.0 163.0 143.8 401.0 206.3 16.9 36.8 2.0 0.0 0.0 0.0 49.3 540.9 60.5 38.3 187.3 198.0 2.1 46.4 2.0 39.5 463.7 130.0 21.6 15.9 639.9 674.0 107.9 26.8 63.5 332.6 236.8 KMT2A "ALL-1, CXXC7, HRX, HTRX1, MLL, MLL1A, TRX1" ENSG00000118058 "Lysine methyltransferase 2A" Q03164 11 118436490-118526832 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Apoptosis, Biological rhythms, Transcription, Transcription regulation" "Chromatin regulator, DNA-binding, Methyltransferase, Transferase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017794, CAB024270, HPA044910" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 15: NK-cells - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 1: K-562 - Erythropoiesis" "Cluster 52: Non-specific - Transcription" Nucleoplasm Cytosol "CAB017794: , CAB024270: , HPA044910: AB_2679141" "unprognostic (6.80e-2)" "unprognostic (8.93e-2)" "unprognostic (1.83e-1)" "unprognostic (4.56e-1)" "unprognostic (4.96e-2)" "unprognostic (1.72e-3)" "unprognostic (4.52e-3)" "unprognostic (6.07e-2)" "unprognostic (1.61e-1)" "unprognostic (8.46e-2)" "unprognostic (3.21e-1)" "unprognostic (1.16e-1)" "unprognostic (5.91e-3)" "unprognostic (7.90e-2)" "unprognostic (3.73e-1)" "unprognostic (1.67e-1)" "unprognostic (1.02e-1)" 9.9 6.7 8.0 8.5 8.6 19.5 9.9 21.2 9.3 10.3 1.6 10.8 5.4 10.7 8.2 6.8 10.3 6.4 6.5 7.4 9.6 6.7 6.0 10.5 12.4 6.3 6.3 21.2 11.1 9.8 10.2 5.6 6.6 9.2 6.4 23.9 9.4 8.4 7.4 10.4 9.8 7.6 3.2 9.7 8.2 5.3 7.0 14.1 9.9 8.4 11.3 10.7 9.3 11.9 17.9 8.6 20.1 14.5 11.1 16.1 6.2 8.7 11.8 9.0 9.6 17.3 11.4 23.1 15.9 10.8 14.6 16.0 22.9 7.2 17.9 26.0 10.0 45.7 8.9 9.3 6.1 28.5 7.8 7.2 7.4 20.3 24.0 8.9 12.8 13.3 32.8 18.8 9.2 12.7 18.2 12.7 13.6 6.6 13.7 13.8 21.9 6.9 9.8 13.8 18.0 11.8 22.0 6.7 3.9 9.8 11.9 9.1 20.4 14.1 12.7 9.4 14.7 5.1 4.4 15.6 4.7 17.6 8.3 2.1 0.6 1.9 1.6 0.6 1.6 2.5 1.8 1.5 0.3 1.8 1.8 1.2 0.5 2.0 0.7 1.4 1.7 0.4 8.0 8.6 21.2 9.3 7.4 9.6 6.3 6.3 6.6 3.2 7.0 11.9 87.1 70.5 65.8 93.4 83.4 86.9 67.6 29.4 64.9 158.1 76.8 73.9 44.5 40.0 32.2 38.6 152.2 13.9 81.0 26.2 3.9 33.0 10.1 62.1 101.4 74.4 66.4 67.3 146.0 25.6 10.2 65.6 44.4 85.2 29.0 57.5 60.0 27.3 16.8 195.2 170.1 29.6 20.3 37.0 63.7 5.8 66.8 44.8 42.7 62.8 49.9 98.9 78.2 106.6 131.9 28.2 20.1 78.6 83.3 88.3 22.7 10.5 52.7 152.4 65.7 113.4 84.6 25.5 30.7 46.3 80.6 6.0 102.8 55.8 30.6 64.8 KMT2B "CXXC10, HRX2, KIAA0304, MLL1B, MLL2, MLL4, TRX2, WBP7" ENSG00000272333 "Lysine methyltransferase 2B" Q9UMN6 19 35717973-35738878 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Chromatin regulator, DNA-binding, Methyltransferase, Transferase" "Cancer-related genes, Disease variant, Dystonia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Bipolar cells: 64.5;Rod photoreceptor cells: 71.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006487 Approved Nucleoplasm,Cytosol NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 43: Testis - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 52: Non-specific - Transcription" Nucleoplasm Cytosol "HPA006487: AB_1080587" "unprognostic (1.09e-2)" "unprognostic (3.53e-2)" "unprognostic (3.41e-2)" "unprognostic (7.95e-2)" "unprognostic (9.92e-2)" "unprognostic (3.53e-3)" "unprognostic (2.33e-2)" "unprognostic (4.57e-2)" "unprognostic (7.28e-2)" "unprognostic (2.07e-2)" "unprognostic (3.13e-3)" "unprognostic (2.63e-3)" "unprognostic (9.47e-3)" "unprognostic (2.10e-1)" "unprognostic (2.37e-1)" "unprognostic (3.77e-2)" "unprognostic (2.24e-2)" 11.6 10.1 15.4 9.8 15.7 14.3 11.8 17.2 22.9 12.9 12.2 13.6 9.8 14.1 4.4 12.8 13.1 6.8 8.4 14.7 14.8 10.3 10.0 12.1 14.5 15.4 14.4 16.1 16.0 5.1 14.5 5.8 14.7 13.4 3.9 5.8 13.3 5.8 16.1 18.8 14.5 4.5 12.4 15.6 12.7 22.5 15.9 9.3 16.6 5.0 6.8 12.6 12.0 16.0 16.7 36.7 11.1 17.3 6.0 4.3 11.0 6.7 4.7 7.3 5.0 25.3 7.4 15.5 11.8 5.1 8.5 10.8 11.3 5.2 4.2 21.2 13.6 29.7 20.2 24.4 8.6 17.4 26.1 6.9 9.4 8.9 10.7 6.9 5.7 13.5 22.5 15.8 6.4 34.1 15.9 24.4 12.0 18.8 9.2 19.8 8.9 7.6 7.8 21.3 14.0 10.0 13.5 20.6 11.3 7.9 11.8 21.3 12.5 16.3 17.0 10.5 17.4 22.2 15.7 12.4 8.5 18.8 12.2 0.3 0.4 0.4 1.0 0.1 0.5 0.4 0.6 0.7 0.3 0.7 0.6 0.9 1.8 0.5 0.2 2.1 0.8 0.4 15.4 15.7 17.2 22.9 14.7 14.8 15.4 14.4 14.7 12.4 15.9 16.0 24.6 9.6 15.4 13.7 18.6 12.7 10.0 6.2 9.6 64.5 16.1 14.6 9.2 8.6 6.3 9.2 52.1 6.5 27.4 25.2 0.0 6.4 2.8 17.9 31.6 15.6 20.3 7.4 11.7 7.7 6.1 12.4 27.5 26.0 5.1 30.5 11.0 11.2 8.4 35.3 11.8 14.1 6.1 11.8 7.1 4.7 8.1 13.4 5.4 7.5 9.5 25.7 19.6 7.5 10.0 8.4 16.7 12.4 17.9 19.6 13.9 5.0 6.7 71.2 0.0 25.0 17.3 26.5 38.5 11.9 12.9 9.4 20.6 30.7 16.3 14.8 KMT2C "HALR, KIAA1506, MLL3" ENSG00000055609 "Lysine methyltransferase 2C" Q8NEZ4 7 152134922-152436641 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, Acyltransferase, Chromatin regulator, DNA-binding, Methyltransferase, Transferase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 363.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 15.2" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA074736 Approved Nucleoplasm NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 80: Striated muscle - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Nucleoplasm "HPA074736: AB_2686709" "unprognostic (7.75e-2)" "unprognostic (3.10e-1)" "unprognostic (2.83e-1)" "unprognostic (1.33e-2)" "unprognostic (1.31e-1)" "unprognostic (5.23e-3)" "unprognostic (1.09e-1)" "unprognostic (1.59e-2)" "unprognostic (1.01e-1)" "unprognostic (1.17e-1)" "unprognostic (3.45e-1)" "unprognostic (1.06e-1)" "prognostic favorable (8.01e-6)" "unprognostic (1.78e-1)" "unprognostic (3.83e-1)" "unprognostic (3.04e-2)" "unprognostic (2.64e-1)" 12.7 11.2 16.7 7.3 25.7 16.4 12.9 16.7 15.7 15.3 5.5 13.1 5.7 14.3 13.7 14.1 11.9 7.7 10.2 13.0 18.9 8.9 10.4 12.7 8.1 25.3 19.4 16.8 18.5 12.4 12.1 10.3 20.6 9.3 7.6 21.7 14.2 9.0 25.9 17.6 12.8 7.5 12.2 12.2 15.2 13.4 19.1 16.1 14.6 16.9 9.5 11.3 12.7 28.6 13.4 6.1 11.6 11.7 19.0 13.9 10.2 4.7 6.4 5.0 5.5 10.9 4.7 22.4 8.9 11.3 9.2 5.2 14.3 7.5 9.2 12.7 6.5 14.0 7.3 4.5 8.9 22.9 12.8 6.6 9.1 7.1 8.2 7.2 8.4 9.7 22.5 15.0 11.7 12.7 14.8 11.1 6.8 8.5 7.9 9.5 12.3 8.4 5.8 10.9 19.6 12.8 13.4 15.8 6.3 10.6 4.6 15.7 12.8 8.0 4.4 9.0 8.9 15.3 7.7 22.4 10.7 14.7 8.4 6.1 3.0 4.4 1.9 2.7 1.6 6.9 2.0 1.5 1.4 3.9 1.9 1.4 15.2 2.2 2.6 3.7 1.3 0.8 16.7 25.7 16.7 15.7 13.0 18.9 25.3 19.4 20.6 12.2 19.1 28.6 62.4 76.9 71.9 292.8 75.0 89.1 38.3 31.5 62.0 89.0 59.6 35.2 65.8 44.3 72.4 46.0 173.0 38.0 61.9 61.7 5.9 37.6 32.1 94.4 92.1 58.9 67.9 55.5 180.7 33.1 51.7 58.3 89.2 200.5 65.2 52.8 56.7 46.0 33.7 80.8 172.2 53.5 42.7 54.7 79.6 17.3 67.4 90.5 42.7 202.4 77.1 57.7 59.8 299.6 363.2 37.6 49.0 60.2 90.3 53.6 36.3 14.7 46.9 73.0 26.3 83.0 55.5 42.3 33.9 80.9 96.3 127.2 76.8 54.8 39.1 61.4 KMT2D "ALR, CAGL114, MLL2, MLL4, TNRC21" ENSG00000167548 "Lysine methyltransferase 2D" O14686 12 49018978-49060794 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Transferase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "neutrophil: 1.5" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA035977 Approved Approved "Nucleoplasm,Plasma membrane,Cytosol" Yes No "Cluster 33: Neutrophils - Chromatin organization" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 1: K-562 - Erythropoiesis" "Cluster 9: Photoreceptor cells - Phototransduction" Cytosol "Nucleoplasm, Plasma membrane" "HPA035977: AB_10670673" "unprognostic (8.33e-2)" "unprognostic (1.49e-1)" "unprognostic (9.14e-2)" "unprognostic (2.52e-1)" "unprognostic (8.07e-2)" "unprognostic (6.91e-3)" "unprognostic (7.35e-2)" "unprognostic (2.29e-1)" "unprognostic (3.57e-1)" "unprognostic (5.14e-2)" "unprognostic (7.23e-2)" "unprognostic (3.07e-1)" "unprognostic (1.68e-2)" "unprognostic (7.10e-2)" "unprognostic (1.87e-1)" "unprognostic (3.20e-2)" "unprognostic (7.60e-2)" 19.9 21.9 14.0 17.0 14.4 62.1 20.3 14.7 18.1 20.2 3.8 21.3 13.2 26.9 14.4 25.5 24.1 11.7 23.7 12.1 9.1 18.2 20.5 25.1 17.5 9.3 8.2 25.3 33.2 22.9 25.4 16.2 8.6 19.2 14.7 48.0 22.1 16.2 44.9 30.4 27.9 15.5 3.1 36.6 25.5 23.6 12.7 29.0 26.5 21.9 17.2 19.4 19.4 13.4 32.3 31.9 31.0 24.7 29.3 20.4 32.6 17.3 17.1 20.3 10.9 54.8 14.1 33.4 21.2 23.9 14.0 21.5 38.1 19.9 17.7 22.4 26.7 47.2 37.7 29.9 20.5 59.1 43.2 18.4 25.8 30.7 32.0 27.3 31.8 33.2 55.1 19.2 23.7 37.4 26.8 48.0 29.9 45.4 25.0 37.4 22.4 12.0 18.1 37.2 24.6 21.2 28.1 25.5 19.5 26.1 24.0 44.1 49.8 15.5 30.7 14.5 30.5 24.8 20.9 31.7 17.1 28.0 12.5 0.5 0.2 0.3 0.2 0.0 0.1 0.1 0.1 0.1 0.0 0.2 0.1 0.1 1.5 0.5 0.0 0.2 0.0 0.1 14.0 14.4 14.7 18.1 12.1 9.1 9.3 8.2 8.6 3.1 12.7 13.4 12.9 9.6 19.1 17.6 13.3 14.0 7.8 8.1 14.2 26.8 12.1 7.1 7.8 12.8 10.9 18.4 52.1 8.2 15.3 12.3 1.9 6.3 2.8 10.7 12.7 13.2 13.1 16.0 17.4 6.0 6.0 8.8 24.5 13.1 8.2 23.3 17.9 13.0 9.8 21.9 16.5 10.0 6.1 15.7 18.4 2.4 9.6 15.4 10.6 15.0 14.9 6.4 17.5 12.5 19.8 8.8 9.5 10.9 10.1 11.0 13.3 4.5 9.0 38.4 6.6 14.4 12.5 6.5 3.8 18.9 17.6 11.4 15.3 10.8 10.3 9.6 KRAS "KRAS1, KRAS2" ENSG00000133703 "KRAS proto-oncogene, GTPase" P01116 12 25205246-25250936 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" Hydrolase "Cancer-related genes, Cardiomyopathy, Deafness, Disease variant, Ectodermal dysplasia, Mental retardation, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049830 Approved NA NA 3300000 "Cluster 18: Basophils - Vesicular transport" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 5: NTERA-2 - Transcription" "Cluster 22: Epithelial cell types - Mixed function" "HPA049830: AB_2680903" "unprognostic (2.24e-2)" "unprognostic (2.16e-2)" "unprognostic (4.86e-3)" "unprognostic (1.08e-2)" "unprognostic (7.39e-2)" "unprognostic (1.51e-1)" "unprognostic (1.47e-2)" "unprognostic (3.74e-2)" "unprognostic (1.79e-1)" "unprognostic (2.39e-1)" "prognostic unfavorable (3.59e-4)" "unprognostic (6.42e-2)" "prognostic favorable (2.75e-5)" "unprognostic (1.95e-2)" "unprognostic (2.37e-1)" "unprognostic (2.81e-2)" "unprognostic (9.97e-2)" 11.8 9.1 11.0 16.2 12.2 27.8 10.0 11.7 12.3 9.5 4.6 22.0 14.0 11.0 6.8 19.3 7.4 13.1 8.6 12.5 12.0 11.7 15.3 13.2 17.9 8.5 9.7 8.0 12.6 11.1 5.7 17.0 8.7 11.8 23.0 22.7 11.9 8.3 7.6 13.6 19.5 13.6 8.1 12.0 20.3 8.9 12.9 17.2 10.8 10.3 17.4 16.2 11.4 8.6 15.9 14.3 39.4 20.7 14.1 19.9 68.9 17.3 22.8 18.0 21.9 51.5 30.7 38.7 10.4 32.0 23.4 18.6 44.9 17.3 34.3 26.7 15.0 37.6 17.6 15.6 15.8 32.8 25.6 18.1 25.5 21.9 20.2 33.6 27.1 28.7 28.0 17.3 27.6 14.1 46.8 56.6 87.6 25.3 7.4 43.4 39.9 59.9 27.2 22.4 11.2 32.4 20.5 24.9 21.8 97.4 28.9 26.9 28.1 18.7 24.8 38.2 22.0 16.4 28.5 41.9 15.4 20.0 15.0 31.2 8.1 13.7 11.6 16.4 7.9 10.7 10.1 13.1 7.9 10.5 13.8 12.4 19.2 11.2 22.4 7.8 7.6 5.8 11.0 12.2 11.7 12.3 12.5 12.0 8.5 9.7 8.7 8.1 12.9 8.6 73.7 48.1 32.1 16.6 90.8 100.9 96.4 57.2 72.3 63.4 59.9 38.0 16.3 64.3 53.6 38.6 73.0 94.2 66.0 161.9 58.7 77.5 3.9 45.4 40.8 77.3 78.8 60.2 42.0 91.8 21.4 50.1 98.4 53.4 24.1 26.6 77.8 56.9 51.5 92.5 45.3 92.9 36.7 53.9 83.7 5.9 40.7 75.3 62.2 28.1 82.9 41.7 49.4 19.6 16.6 114.2 104.7 51.6 85.0 130.1 63.0 52.3 42.5 65.8 26.3 53.7 52.2 53.0 40.3 93.0 155.7 139.1 83.0 36.5 96.7 176.9 LMO2 "RBTN2, RBTNL1, RHOM2, TTG2" ENSG00000135363 "LIM domain only 2" P25791 11 33858576-33892076 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Adipocytes: 109.2;Endothelial cells: 144.6;Erythroid cells: 103.7;Hepatic stellate cells: 167.4;Kupffer cells: 65.0;Microglial cells: 64.6" "Cancer enhanced" "Detected in all" "glioma: 30.0" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Group enriched" "Detected in many" 6 "dendritic cells: 1.9;granulocytes: 1.5;monocytes: 1.7" "Cell line enhanced" "Detected in some" "HEL: 71.8;HL-60: 72.7;K-562: 60.9;NB-4: 27.3;THP-1: 81.6;U-937: 29.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB016258, HPA029285, HPA070901, HPA070910" Approved Enhanced Nucleoplasm NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 32: U-937 - Innate immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Nucleoplasm "CAB016258: AB_2136572, HPA029285: AB_2672978, HPA070901: , HPA070910: " "unprognostic (1.60e-1)" "unprognostic (1.47e-2)" "unprognostic (6.03e-2)" "unprognostic (1.71e-3)" "unprognostic (1.89e-1)" "unprognostic (1.14e-3)" "prognostic favorable (3.12e-4)" "unprognostic (1.73e-3)" "unprognostic (8.95e-2)" "unprognostic (5.76e-2)" "unprognostic (7.86e-3)" "unprognostic (3.69e-1)" "unprognostic (7.10e-2)" "unprognostic (9.65e-2)" "unprognostic (3.90e-1)" "unprognostic (1.45e-1)" "unprognostic (4.46e-2)" 15.0 5.9 14.9 11.4 13.0 27.7 12.5 14.2 16.6 8.4 13.4 5.0 4.6 6.5 0.7 6.8 8.3 5.4 4.4 14.7 16.0 13.1 2.3 18.2 19.4 19.9 16.3 3.5 2.6 2.3 8.6 6.5 18.5 5.7 1.5 0.6 5.3 2.4 23.4 4.9 6.6 4.8 18.7 19.0 3.9 1.7 19.0 1.8 12.3 4.6 8.4 5.8 7.3 13.3 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.2 0.0 0.0 2.2 1.3 12.8 0.0 0.7 0.0 0.0 0.3 0.0 0.0 0.4 71.8 0.0 0.0 0.3 72.7 18.5 0.0 0.0 0.0 0.0 0.0 10.2 0.0 60.9 0.0 0.0 0.3 5.1 27.3 0.9 0.0 0.0 15.3 0.8 0.2 0.0 0.8 4.3 0.0 0.3 0.5 0.1 0.2 0.0 81.6 0.9 0.0 0.2 1.7 0.0 0.0 0.2 0.6 4.7 29.2 0.3 0.6 0.5 1.5 0.0 1.4 0.0 0.2 0.0 0.0 1.9 0.0 0.0 0.0 0.7 0.0 1.7 0.1 0.0 0.2 14.9 13.0 14.2 16.6 14.7 16.0 19.9 16.3 18.5 18.7 19.0 13.3 109.2 3.2 7.1 8.5 6.6 8.4 7.9 8.0 0.6 1.6 2.8 9.5 2.8 8.6 1.7 5.5 2.1 0.4 1.0 0.8 0.0 3.0 0.5 40.5 11.0 144.6 0.0 103.7 1.3 2.0 3.2 9.8 0.0 39.6 7.6 0.9 167.4 1.7 39.1 0.0 3.8 0.2 2.0 65.0 56.8 1.2 4.1 54.1 10.6 64.6 47.5 1.1 4.1 5.0 1.0 1.0 1.9 0.0 3.0 5.4 0.0 8.8 5.0 2.6 0.0 17.3 3.6 0.3 7.9 0.8 6.0 21.5 1.9 12.4 0.5 25.1 LRP6 ADCAD2 ENSG00000070018 "LDL receptor related protein 6" O75581 12 12116025-12267044 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Endocytosis, Wnt signaling pathway" "Developmental protein, Receptor" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 96.6;Oligodendrocyte precursor cells: 108.0;Oligodendrocytes: 97.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004490, HPA029925" Enhanced NA NA 390000 "Cluster 46: Fibroblasts - ECM organization" "Cluster 5: NTERA-2 - Transcription" "Cluster 68: Oligodendrocytes - Mixed function" "CAB004490: AB_627894, HPA029925: AB_10601768" "unprognostic (1.80e-1)" "unprognostic (3.72e-1)" "unprognostic (2.76e-1)" "unprognostic (1.91e-1)" "unprognostic (6.11e-2)" "unprognostic (1.07e-1)" "unprognostic (4.56e-2)" "unprognostic (1.37e-2)" "unprognostic (3.35e-2)" "unprognostic (6.98e-2)" "unprognostic (1.82e-1)" "unprognostic (5.00e-2)" "unprognostic (1.55e-1)" "unprognostic (2.44e-2)" "unprognostic (3.16e-1)" "unprognostic (1.23e-2)" "unprognostic (2.47e-1)" 3.7 2.2 2.0 1.2 3.9 0.2 4.5 2.5 2.0 6.6 13.5 4.6 2.8 6.5 1.9 2.0 4.4 2.8 3.3 2.0 2.8 4.4 7.9 4.6 0.8 2.2 2.7 5.4 4.9 6.2 2.6 8.3 1.7 3.4 2.8 2.8 6.8 3.2 4.5 3.4 2.7 4.1 1.8 0.9 3.4 2.1 2.8 1.2 4.5 4.6 1.0 3.4 5.3 2.9 3.9 13.3 9.9 5.3 6.1 4.0 7.8 5.8 5.4 4.6 5.3 6.5 3.6 0.0 2.8 5.6 3.8 3.7 14.6 3.7 8.7 0.0 3.9 4.1 4.9 3.2 2.1 5.7 2.8 3.2 2.0 6.9 5.4 5.1 4.8 4.1 5.0 0.0 3.0 3.2 4.2 1.1 14.4 2.2 1.7 5.3 9.2 1.0 6.8 7.6 2.0 5.6 7.4 2.5 6.0 11.5 2.0 3.7 6.9 3.6 13.2 2.6 4.9 0.0 0.0 1.9 2.9 0.0 6.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.0 3.9 2.5 2.0 2.0 2.8 2.2 2.7 1.7 1.8 2.8 2.9 21.6 41.7 49.5 96.6 1.0 15.4 8.6 11.9 9.6 28.2 20.1 19.0 15.4 11.5 16.6 14.7 22.9 3.7 0.5 20.4 1.9 9.0 1.0 18.0 39.0 25.9 10.8 0.4 58.2 13.7 3.2 24.0 25.5 29.1 0.0 32.8 22.1 46.7 2.3 6.7 58.0 12.9 10.2 2.4 6.0 5.1 30.4 1.7 14.2 35.6 0.6 19.9 1.0 108.0 97.0 11.3 20.5 38.7 1.6 14.7 15.1 5.2 6.0 29.0 0.0 21.5 17.3 21.5 26.4 11.0 13.8 3.4 1.9 23.7 14.4 8.1 LYL1 bHLHa18 ENSG00000104903 "LYL1 basic helix-loop-helix family member" P12980 19 13099033-13103161 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" DNA-binding "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 35.9;lymphoid tissue: 36.7" "Cell type enhanced" "Detected in many" "Early spermatids: 335.4;Erythroid cells: 298.9;Late spermatids: 763.9;Spermatocytes: 120.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 6.4" "Group enriched" "Detected in many" 4 "B-cells: 3.7;granulocytes: 6.4;monocytes: 2.8" "Cell line enhanced" "Detected in many" "HEL: 127.7;HL-60: 90.5;HMC-1: 206.6;K-562: 102.1;NB-4: 131.9;REH: 96.5;THP-1: 86.1;U-937: 86.1" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA072177 Approved Nucleoplasm NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 2: Immune cells - Immune response" "Cluster 1: K-562 - Erythropoiesis" "Cluster 6: Erythroid cells - Oxygen transport" Nucleoplasm "HPA072177: " "unprognostic (8.62e-2)" "unprognostic (1.58e-1)" "unprognostic (1.27e-2)" "unprognostic (3.29e-3)" "unprognostic (2.76e-1)" "unprognostic (3.64e-3)" "unprognostic (2.46e-1)" "unprognostic (1.05e-2)" "unprognostic (1.90e-2)" "unprognostic (5.87e-2)" "unprognostic (1.78e-3)" "unprognostic (1.36e-1)" "prognostic unfavorable (3.89e-4)" "unprognostic (1.18e-1)" "unprognostic (6.54e-2)" "unprognostic (1.33e-1)" "unprognostic (4.28e-1)" 9.7 4.1 6.3 10.9 6.0 35.9 7.3 7.1 7.5 6.7 4.9 6.4 2.0 7.7 0.3 3.2 5.8 1.4 10.1 6.4 6.4 5.7 2.6 12.3 12.3 8.9 6.8 2.8 2.0 0.5 2.5 5.6 8.1 5.7 0.6 0.0 3.7 1.3 2.8 3.2 14.1 1.8 9.1 36.7 4.1 20.8 9.0 2.3 5.3 1.9 6.2 7.8 5.6 9.6 0.1 0.3 0.2 0.0 0.0 0.3 0.0 1.4 0.2 0.4 0.1 0.5 0.0 24.8 8.4 0.2 0.0 0.1 0.4 0.0 0.0 14.7 0.0 127.7 0.1 1.2 1.4 90.5 206.6 0.4 0.0 0.1 0.0 0.0 31.9 0.0 102.1 4.4 0.0 0.0 0.5 131.9 0.0 0.4 3.2 96.5 0.3 11.2 0.0 0.0 0.1 9.1 2.8 0.0 6.0 0.0 0.0 86.1 51.8 0.0 0.1 3.6 0.1 0.0 0.0 20.3 0.1 86.1 0.1 2.4 1.4 6.4 0.0 1.9 0.1 2.1 0.2 0.1 1.0 3.7 0.1 0.1 2.4 0.0 2.8 0.3 0.4 0.4 6.3 6.0 7.1 7.5 6.4 6.4 8.9 6.8 8.1 9.1 9.0 9.6 33.7 0.0 0.5 0.0 80.1 2.5 0.5 0.1 0.6 0.0 1.0 1.4 2.3 2.8 0.2 1.8 0.0 0.7 6.6 1.6 0.0 0.4 335.4 0.4 1.9 40.1 1.8 298.9 0.4 0.0 1.3 3.2 1.1 0.2 45.1 0.8 32.9 1.1 113.2 0.0 0.3 1.2 0.0 60.3 35.1 763.9 8.1 68.3 7.2 13.1 36.4 1.5 4.1 0.5 1.3 2.0 1.6 12.0 6.3 0.4 1.7 0.5 1.7 0.2 13.1 1.8 2.2 120.6 5.8 1.4 1.8 1.5 9.0 0.5 1.0 0.6 MAF c-MAF ENSG00000178573 "MAF bZIP transcription factor" O75444 16 79585843-79600737 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding, Repressor" "Cancer-related genes, Cataract, Deafness, Disease variant, Dwarfism, Mental retardation, Proto-oncogene, Tumor suppressor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hepatic stellate cells: 407.6;Hofbauer cells: 273.6;Inhibitory neurons: 378.7;Kupffer cells: 394.7;Proximal enterocytes: 288.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 4 "basophil: 38.1" "Lineage enriched" "Detected in many" 4 "granulocytes: 38.1" "Group enriched" "Detected in some" 13 "Karpas-707: 207.0;RPMI-8226: 355.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010296, HPA028289" Approved NA NA "Cluster 38: Basophils - Unknown function" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 25: RPMI-8226 - Immune response" "Cluster 24: Non-specific - Transcription regulation" "CAB010296: AB_638562, HPA028289: AB_10602024" "unprognostic (6.76e-2)" "unprognostic (1.74e-2)" "unprognostic (6.45e-2)" "unprognostic (7.65e-2)" "unprognostic (7.89e-3)" "unprognostic (1.07e-2)" "unprognostic (1.63e-2)" "unprognostic (2.33e-1)" "unprognostic (8.76e-2)" "unprognostic (3.16e-2)" "unprognostic (9.46e-2)" "unprognostic (1.28e-1)" "prognostic unfavorable (3.74e-4)" "unprognostic (4.54e-2)" "unprognostic (7.83e-2)" "unprognostic (1.09e-2)" "unprognostic (4.56e-3)" 27.8 15.4 14.6 20.7 14.5 4.0 17.3 10.3 13.5 35.0 14.2 11.4 70.3 23.5 6.0 22.6 20.1 16.7 6.8 13.7 13.0 48.2 25.7 18.8 30.9 19.0 22.6 39.2 3.2 50.8 5.3 36.1 17.6 18.4 10.7 4.7 11.8 15.4 49.6 57.8 83.0 17.8 18.7 26.0 13.0 10.0 28.7 17.9 23.1 19.8 23.9 17.7 30.5 29.8 0.0 0.0 22.4 0.0 0.8 0.0 0.5 2.2 0.1 0.0 0.0 0.3 0.0 0.1 0.0 1.2 0.0 0.8 0.7 0.4 0.0 7.2 8.3 0.0 0.0 0.2 1.0 0.1 14.3 0.1 6.4 0.0 0.2 0.0 0.0 0.3 2.4 207.0 1.5 0.1 0.2 0.4 13.5 0.0 0.0 0.1 6.2 355.1 0.0 1.9 0.5 0.3 0.9 0.2 0.6 8.7 0.2 0.0 4.5 0.0 6.9 0.5 0.9 0.0 0.0 0.0 0.9 0.0 1.4 38.1 0.3 0.0 1.1 1.1 8.6 0.0 3.2 2.7 0.1 0.0 0.2 0.5 0.0 0.9 0.3 0.0 4.7 0.6 14.6 14.5 10.3 13.5 13.7 13.0 19.0 22.6 17.6 18.7 28.7 29.8 40.2 9.6 14.6 24.8 10.4 88.3 3.7 30.1 51.2 9.7 8.5 33.1 8.2 57.2 7.7 3.7 0.0 1.7 71.5 18.2 11.7 1.7 1.1 8.1 114.1 42.7 3.0 8.4 5.1 0.8 3.0 73.0 12.8 6.6 22.1 73.0 407.6 63.7 273.6 0.0 378.7 8.9 16.2 394.7 57.9 9.0 149.8 127.2 44.4 122.7 2.7 78.1 40.2 67.3 20.0 4.0 9.9 115.1 48.1 33.9 288.9 146.6 3.0 2.7 13.1 42.7 40.0 1.1 2.0 107.4 141.2 4.2 122.2 28.0 10.1 5.4 MAML2 "KIAA1819, MAM3" ENSG00000184384 "Mastermind like transcriptional coactivator 2" Q8IZL2 11 95976598-96343195 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Notch signaling pathway, Transcription, Transcription regulation" Activator "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 690.5;Microglial cells: 579.9;Oligodendrocyte precursor cells: 1300.8;Oligodendrocytes: 311.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HDLM-2: 52.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA035223 Approved Supported "Nucleoplasm,Nuclear bodies,Cytosol" No No "Cluster 40: NK-cells - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 44: HDLM-2 - Immune response" "Cluster 68: Oligodendrocytes - Mixed function" "Nuclear bodies" "Nucleoplasm, Cytosol" "HPA035223: AB_10671101" "unprognostic (8.11e-2)" "unprognostic (2.51e-1)" "unprognostic (7.08e-2)" "unprognostic (9.07e-2)" "unprognostic (3.57e-3)" "unprognostic (3.32e-2)" "unprognostic (3.66e-2)" "unprognostic (2.33e-1)" "unprognostic (3.99e-2)" "unprognostic (8.05e-2)" "prognostic unfavorable (3.89e-4)" "unprognostic (9.11e-2)" "prognostic favorable (1.90e-4)" "unprognostic (9.76e-2)" "unprognostic (1.73e-2)" "unprognostic (1.99e-1)" "unprognostic (7.19e-2)" 10.9 2.7 5.8 6.3 5.5 3.1 14.2 17.2 3.9 10.6 6.9 6.1 3.0 5.4 1.8 5.5 8.0 7.7 4.4 7.1 10.6 9.9 2.4 9.8 8.7 9.0 9.0 7.9 5.9 5.9 4.0 12.2 7.4 7.4 6.2 6.8 11.0 5.7 2.0 7.9 4.8 6.5 7.0 10.3 4.8 2.3 7.5 13.7 6.5 4.8 7.0 8.8 6.5 6.6 10.7 2.0 17.8 4.7 18.1 20.7 3.8 12.1 17.9 7.8 8.1 1.3 22.1 2.3 27.7 28.1 4.1 9.6 3.6 11.7 10.7 52.8 1.3 1.4 3.7 4.1 10.5 0.1 0.0 30.4 1.1 13.9 8.2 14.3 4.5 0.3 6.1 3.2 14.0 0.9 0.2 2.9 1.9 5.5 3.3 3.7 3.4 12.3 11.6 14.8 0.1 1.6 4.5 1.9 5.0 5.7 1.7 0.5 19.7 13.6 3.2 4.7 7.7 2.2 0.4 3.3 6.5 2.0 25.6 0.1 0.6 0.0 0.8 0.3 1.3 0.9 1.6 2.1 0.6 1.2 3.2 2.2 2.6 2.4 0.4 0.5 0.6 1.2 5.8 5.5 17.2 3.9 7.1 10.6 9.0 9.0 7.4 7.0 7.5 6.6 43.5 16.0 8.6 690.5 35.4 19.5 21.5 12.6 19.9 44.1 28.6 43.1 5.3 18.6 16.6 12.9 91.8 15.4 21.8 31.0 11.7 19.3 1.4 61.6 49.4 24.0 6.7 2.7 81.6 0.4 26.0 41.6 20.9 52.3 1.3 44.0 9.3 0.4 18.6 0.0 36.8 7.6 4.1 19.2 21.2 3.0 8.7 29.3 12.4 579.9 26.0 21.9 16.5 1300.8 311.4 15.0 16.8 8.6 18.1 19.1 9.4 17.1 24.2 25.9 32.9 3.6 51.5 0.6 0.8 19.4 13.5 13.0 38.1 9.0 14.3 19.2 MAP2K1 "MAPKK1, MEK1, PRKMK1" ENSG00000169032 "Mitogen-activated protein kinase kinase 1" Q02750 15 66386837-66491544 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Cardiomyopathy, Disease variant, Ectodermal dysplasia, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hepatocytes: 172.5;Langerhans cells: 265.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003834, HPA026430" Approved Enhanced "Plasma membrane,Cytosol" NA NA 120000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 39: Non-specific - Mitochondria" "Cluster 18: U-2197 - ECM organization" "Cluster 41: Macrophages - Immune response" "Plasma membrane, Cytosol" "CAB003834: AB_562310, HPA026430: AB_1853742" "unprognostic (4.05e-2)" "unprognostic (1.23e-2)" "unprognostic (2.07e-1)" "unprognostic (4.92e-2)" "prognostic unfavorable (1.95e-4)" "unprognostic (1.81e-3)" "unprognostic (5.78e-2)" "unprognostic (9.91e-3)" "unprognostic (1.11e-1)" "unprognostic (1.77e-1)" "unprognostic (1.45e-1)" "unprognostic (7.62e-3)" "unprognostic (1.20e-1)" "unprognostic (2.71e-1)" "unprognostic (1.96e-1)" "unprognostic (1.15e-1)" "unprognostic (9.40e-3)" 57.9 31.0 47.6 38.3 79.7 63.7 32.5 30.2 61.3 31.1 22.5 26.5 19.4 26.3 29.6 51.8 23.7 27.0 40.7 69.4 44.3 31.2 105.3 34.7 49.5 31.6 32.6 25.7 22.4 38.5 26.8 29.6 40.1 26.2 23.6 34.1 29.3 21.8 85.5 23.7 27.0 31.9 35.7 32.6 24.1 15.2 42.8 33.8 22.8 51.3 55.4 31.2 33.7 49.9 105.8 55.3 94.4 39.0 55.3 41.3 53.8 83.6 61.6 76.6 68.1 79.0 82.1 96.8 93.2 59.9 58.2 93.3 88.8 106.4 89.8 79.1 56.8 30.9 50.4 40.7 45.1 41.0 45.3 32.3 64.0 55.9 81.6 81.5 60.7 48.0 54.3 116.7 113.4 40.3 33.5 51.9 47.9 93.9 42.9 39.2 58.1 84.7 74.8 48.5 58.3 31.7 60.8 45.5 63.0 74.9 41.0 33.7 90.8 99.5 63.8 71.1 112.4 74.0 143.1 60.6 105.1 69.9 48.4 3.0 7.5 5.4 6.4 7.7 5.8 2.8 5.6 6.1 7.7 4.6 6.9 4.2 3.5 8.3 7.7 15.1 4.6 2.8 47.6 79.7 30.2 61.3 69.4 44.3 31.6 32.6 40.1 35.7 42.8 49.9 24.5 28.9 24.8 24.2 40.0 82.8 45.9 32.3 21.1 10.0 22.2 10.2 21.5 40.0 24.9 25.8 14.6 48.1 45.0 25.1 46.9 69.4 12.1 16.3 13.9 34.6 21.7 19.0 69.7 23.1 48.8 30.3 17.9 35.4 8.9 19.8 18.9 172.5 51.4 10.1 46.4 15.4 20.3 90.7 265.3 23.6 22.4 115.1 53.4 48.7 87.9 34.9 35.0 28.1 31.7 103.9 23.5 21.8 49.1 87.7 22.2 35.9 17.7 7.8 6.6 16.3 52.4 35.6 42.7 30.3 67.3 51.7 54.0 5.9 19.1 65.4 MAP2K2 "MEK2, PRKMK2" ENSG00000126934 "Mitogen-activated protein kinase kinase 2" P36507 19 4090321-4124122 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Cardiomyopathy, Disease variant, Ectodermal dysplasia, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 724.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003835, HPA051993" Supported Supported Cytosol NA NA 140000 "Cluster 52: Eosinophils - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 25: Spermatids - Spermatogenesis" Cytosol "CAB003835: AB_562312, HPA051993: AB_2681685" "unprognostic (4.39e-1)" "prognostic favorable (3.72e-4)" "unprognostic (4.24e-1)" "unprognostic (1.26e-3)" "unprognostic (2.58e-1)" "prognostic favorable (7.98e-4)" "unprognostic (2.08e-3)" "unprognostic (2.11e-1)" "unprognostic (2.65e-1)" "unprognostic (1.06e-1)" "unprognostic (7.45e-3)" "unprognostic (4.95e-2)" "unprognostic (1.32e-1)" "prognostic favorable (5.43e-5)" "unprognostic (2.91e-2)" "unprognostic (2.25e-1)" "unprognostic (4.90e-2)" 73.9 118.4 145.5 54.1 143.1 102.4 69.1 151.5 190.7 76.6 150.4 103.4 134.0 72.3 23.2 121.6 64.7 30.4 156.6 145.9 147.3 82.6 123.3 66.8 57.1 149.6 152.9 84.1 134.3 54.9 99.3 36.4 154.3 93.9 42.7 68.0 79.6 37.6 289.0 95.8 101.0 31.7 143.5 89.1 92.7 131.6 150.7 69.3 74.6 132.1 41.0 77.2 75.2 142.8 163.1 175.4 93.7 132.8 127.1 151.9 93.8 104.5 138.8 139.6 125.8 153.0 85.5 137.7 95.9 120.0 111.9 114.3 74.2 111.6 107.4 118.1 90.4 50.5 91.4 171.7 194.0 93.6 101.8 168.8 106.8 98.2 129.5 185.5 125.2 123.0 98.1 263.1 119.3 203.5 186.3 130.6 107.8 118.6 125.9 140.7 61.9 159.1 123.5 102.7 126.8 126.3 95.7 130.6 344.1 107.3 101.0 158.5 111.8 113.6 98.2 293.4 163.9 263.1 172.4 100.2 176.5 166.8 199.3 27.5 13.0 45.4 16.9 16.6 13.6 13.0 13.3 17.2 15.9 18.2 12.3 15.9 21.2 18.8 14.1 9.0 14.3 7.3 145.5 143.1 151.5 190.7 145.9 147.3 149.6 152.9 154.3 143.5 150.7 142.8 77.7 9.6 31.9 22.5 62.3 35.4 93.3 21.3 15.4 85.1 92.9 95.4 62.9 44.3 22.8 40.5 41.7 28.7 102.3 300.5 146.8 20.7 248.1 59.5 68.3 52.1 63.2 123.1 17.6 45.5 38.6 60.3 64.7 48.8 19.7 124.4 49.2 48.1 55.0 121.1 23.2 107.7 16.2 56.0 38.2 724.3 35.8 65.6 42.7 10.3 28.5 121.1 62.8 13.0 24.2 47.0 151.8 23.0 79.9 103.2 166.1 92.8 18.9 106.8 26.3 93.1 71.8 23.5 17.4 42.9 63.9 35.6 77.0 120.2 119.9 113.1 MAX "bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8" ENSG00000125952 "MYC associated factor X" P61244 14 65006174-65102695 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding, Repressor" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HMC-1: 390.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000328, HPA003474" Supported Supported "Nucleoplasm,Golgi apparatus,Vesicles" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 3: HMC-1 - Innate immune response" "Cluster 51: Myeloid cells - Hemostasis" Nucleoplasm "Golgi apparatus, Vesicles" "CAB000328: AB_2281783, HPA003474: AB_1079317" "unprognostic (4.50e-3)" "unprognostic (1.51e-3)" "unprognostic (4.08e-2)" "unprognostic (2.87e-1)" "unprognostic (8.37e-2)" "unprognostic (2.42e-2)" "unprognostic (1.13e-3)" "unprognostic (1.30e-3)" "unprognostic (1.53e-2)" "unprognostic (7.36e-3)" "unprognostic (7.19e-2)" "unprognostic (1.66e-2)" "prognostic unfavorable (5.57e-4)" "unprognostic (2.99e-1)" "unprognostic (4.68e-2)" "prognostic favorable (2.12e-4)" "unprognostic (6.03e-2)" 48.1 36.3 57.4 43.5 63.2 105.1 41.2 74.6 62.9 61.0 44.8 51.1 41.3 51.1 29.2 75.8 67.2 36.2 52.8 55.0 59.4 39.5 36.8 51.6 63.7 65.5 61.8 56.2 29.3 31.3 32.5 39.8 65.0 52.2 31.8 23.6 43.5 38.7 43.8 55.3 51.7 39.5 59.4 66.3 39.4 21.5 62.1 63.7 42.7 54.0 55.1 51.3 68.7 65.3 117.1 40.4 27.8 44.6 73.4 58.0 35.4 39.9 62.3 47.5 58.4 29.1 86.7 88.1 33.1 48.8 45.0 60.4 63.4 52.7 37.3 84.5 40.5 143.4 29.9 32.0 90.9 56.2 390.3 67.6 43.5 42.7 54.9 71.9 54.9 71.8 66.8 42.4 53.1 63.9 140.1 217.6 36.3 71.3 70.6 75.2 42.7 47.3 49.2 38.8 61.8 38.2 49.6 60.6 60.4 25.1 58.0 71.6 69.7 47.8 55.8 42.0 33.6 50.7 43.6 61.7 56.9 56.1 46.0 667.6 141.9 540.8 125.7 126.4 140.1 115.7 147.5 130.5 119.9 114.9 151.1 127.9 305.1 126.9 120.3 114.6 194.0 314.2 57.4 63.2 74.6 62.9 55.0 59.4 65.5 61.8 65.0 59.4 62.1 65.3 45.8 28.9 27.4 31.0 74.5 170.2 66.0 63.3 126.3 28.2 59.8 43.1 27.4 32.9 42.0 18.4 20.9 38.4 79.1 116.3 52.8 38.8 45.5 38.1 43.6 59.9 44.3 40.4 50.7 31.4 43.4 46.7 32.6 36.0 62.8 38.2 71.0 23.8 59.9 47.1 43.3 49.7 38.7 81.8 66.7 115.6 77.9 147.2 56.9 32.8 67.1 47.3 69.0 28.1 60.4 61.6 96.7 60.2 58.0 80.3 100.6 66.4 32.9 16.9 138.1 47.4 76.3 43.2 28.4 84.8 180.6 54.0 83.9 25.4 29.7 76.2 MC2R ACTHR ENSG00000185231 "Melanocortin 2 receptor" Q01718 18 13882044-13915707 "Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins, Transporters" "G-protein coupled receptor, Receptor, Transducer" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 33 "adrenal gland: 57.9" "Cell type enhanced" "Detected in single" "Late spermatids: 1.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA079148 Enhanced NA NA "Cluster 17: Adrenal gland - Steroid metabolism" "Cluster 31: Spermatids - Spermatogenesis" "HPA079148: " "unprognostic (2.09e-1)" "unprognostic (3.63e-2)" "unprognostic (1.85e-2)" 0.0 57.9 0.0 0.1 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.8 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 MDM2 "HDM2, MGC5370" ENSG00000135679 "MDM2 proto-oncogene" Q00987 12 68808177-68850686 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Ubl conjugation pathway" Transferase "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Endometrial ciliated cells: 257.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HBEC3-KT: 504.6;U-698: 517.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000086, CAB016303, CAB079977" Supported Supported "Nucleoplasm,Golgi apparatus,Cytosol" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 49: Ciliated cells - Cilium organization" "Nucleoplasm, Cytosol" "Golgi apparatus" "CAB000086: AB_563872, CAB016303: AB_627920, CAB079977: " "unprognostic (1.16e-1)" "prognostic favorable (3.23e-4)" "unprognostic (6.16e-2)" "prognostic favorable (4.51e-7)" "unprognostic (7.25e-2)" "unprognostic (6.91e-2)" "unprognostic (3.77e-2)" "unprognostic (1.72e-1)" "unprognostic (2.45e-2)" "unprognostic (3.23e-1)" "unprognostic (1.80e-3)" "unprognostic (2.36e-1)" "unprognostic (4.22e-2)" "unprognostic (4.59e-2)" "unprognostic (1.81e-1)" "unprognostic (2.68e-1)" "unprognostic (8.95e-2)" 14.0 11.6 5.4 10.4 10.0 28.6 11.9 7.4 7.6 13.9 28.0 20.7 6.4 9.5 7.1 13.0 14.1 12.0 6.8 3.8 7.4 9.5 26.9 14.3 13.8 9.9 8.5 10.8 14.3 10.9 5.0 16.4 9.2 11.3 21.9 14.2 9.6 11.5 18.6 10.9 7.5 12.4 6.0 11.4 10.0 6.6 9.2 15.6 15.4 12.9 17.0 15.1 10.8 12.8 18.7 42.1 43.5 22.6 55.9 51.5 223.4 49.7 50.3 26.2 41.5 26.8 8.4 188.6 13.5 34.7 7.3 11.0 31.4 504.6 42.1 51.0 22.0 35.3 36.0 115.0 55.7 32.6 31.0 77.8 46.5 101.5 69.4 26.9 73.7 32.1 37.1 45.4 50.8 28.0 43.1 10.7 36.9 10.1 8.2 149.4 31.7 16.2 16.0 146.0 34.3 20.2 32.0 25.0 11.3 88.8 58.3 21.4 82.3 20.2 38.0 16.8 18.5 68.2 47.7 517.6 31.3 12.8 81.2 6.1 5.4 5.2 4.1 4.1 3.7 4.7 3.5 4.1 3.0 5.4 3.6 3.5 19.2 3.7 7.2 3.9 4.1 3.6 5.4 10.0 7.4 7.6 3.8 7.4 9.9 8.5 9.2 6.0 9.2 12.8 23.1 32.1 56.3 26.1 36.4 15.6 30.5 42.6 22.8 26.8 21.4 17.1 20.9 24.3 75.8 25.8 33.3 47.5 32.1 19.3 13.7 19.5 2.5 257.4 34.5 22.0 25.1 29.9 28.8 24.2 28.0 31.9 28.5 74.8 32.9 33.2 15.7 45.0 18.3 30.3 32.9 23.4 32.6 49.0 25.0 2.9 19.3 44.9 12.4 37.5 35.4 27.8 10.3 25.6 71.8 22.4 20.1 15.1 117.7 39.8 15.8 21.3 141.7 35.3 19.7 30.0 32.4 17.3 20.0 59.5 22.0 94.3 31.8 49.4 20.9 82.0 MDM4 "HDMX, MDMX" ENSG00000198625 "MDM4 regulator of p53" O15151 1 204516379-204558120 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "BEWO: 58.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018919, HPA048821" Approved Supported Nucleoplasm NA NA "Cluster 37: B-cells - Transcription" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 28: BEWO - Transcription regulation" "Cluster 52: Non-specific - Transcription" Nucleoplasm "HPA018919: AB_1853694, HPA048821: AB_2680531" "unprognostic (4.63e-2)" "unprognostic (3.73e-1)" "unprognostic (6.38e-2)" "unprognostic (1.50e-1)" "unprognostic (3.84e-2)" "unprognostic (1.68e-3)" "unprognostic (2.33e-1)" "unprognostic (1.29e-1)" "unprognostic (1.51e-2)" "unprognostic (2.34e-2)" "unprognostic (1.17e-2)" "prognostic unfavorable (9.87e-4)" "prognostic unfavorable (7.06e-6)" "unprognostic (1.20e-1)" "unprognostic (1.73e-1)" "unprognostic (2.49e-2)" "prognostic favorable (2.49e-4)" 13.7 10.5 9.2 13.4 18.7 56.1 14.3 16.3 12.1 17.6 35.0 12.4 5.8 12.0 18.6 11.5 13.6 6.7 11.4 10.6 17.8 14.4 14.8 16.3 18.8 17.5 14.6 18.9 18.8 5.3 16.3 10.1 17.5 14.6 9.6 25.2 11.9 7.3 10.5 20.7 16.7 7.1 10.5 22.6 13.2 19.9 15.9 30.4 15.8 4.2 17.4 12.1 13.7 36.0 6.5 12.7 12.5 17.3 8.6 9.4 58.7 4.8 4.9 6.1 8.9 6.6 8.7 22.4 4.5 6.7 5.1 6.8 8.5 7.2 8.2 6.8 6.0 17.8 32.0 7.6 6.5 14.0 16.9 9.4 4.5 9.9 17.4 6.3 6.0 14.2 10.4 31.5 5.4 21.9 8.6 12.3 17.3 2.4 5.3 10.1 10.2 7.5 6.0 31.1 5.6 12.6 4.9 9.1 9.1 12.4 18.0 8.1 6.1 6.8 12.1 4.5 7.9 15.8 6.2 18.2 4.7 5.9 10.1 7.5 4.3 5.8 5.7 4.2 4.9 7.9 4.4 4.1 3.6 11.9 6.1 5.4 6.4 4.1 3.8 7.8 2.6 2.5 9.2 18.7 16.3 12.1 10.6 17.8 17.5 14.6 17.5 10.5 15.9 36.0 73.6 28.9 56.9 76.0 118.1 61.6 48.2 31.0 22.8 96.0 55.2 33.7 38.5 47.1 51.2 69.9 168.9 52.0 135.7 35.5 13.7 29.9 82.3 39.6 74.2 54.5 65.0 64.4 61.8 26.7 26.1 53.0 36.7 63.2 65.9 82.6 87.1 61.0 35.5 42.1 65.7 48.3 54.9 96.4 128.3 160.2 80.2 62.0 42.7 83.4 81.8 40.1 90.6 106.6 170.3 26.5 42.3 54.2 81.0 66.3 49.0 18.6 32.0 192.7 52.6 99.6 50.5 75.7 64.8 23.0 68.3 60.9 73.7 58.2 51.1 48.3 MECOM "EVI1, KMT8E, MDS1, MDS1-EVI1, PRDM3" ENSG00000085276 "MDS1 and EVI1 complex locus" Q03112 3 169083499-169663775 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Apoptosis, Differentiation, Transcription, Transcription regulation" "Developmental protein, DNA-binding, Methyltransferase, Transferase" "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "stomach 1: 73.3" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 184.8;Collecting duct cells: 125.0;Gastric mucus-secreting cells: 111.1;Glandular and luminal cells: 107.7;Microglial cells: 346.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "plasmacytoid DC: 1.6" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "HUVEC TERT2: 55.5;RPTEC TERT1: 71.2;RT4: 119.6;TIME: 53.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046537 Supported Supported "Nuclear speckles" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 46: Fibroblasts - ECM organization" "Cluster 15: RT4 - Unknown function" "Cluster 44: Endometrium - Transcription" "Nuclear speckles" "HPA046537: AB_2679689" "unprognostic (4.09e-2)" "unprognostic (1.96e-1)" "unprognostic (3.24e-3)" "unprognostic (7.29e-2)" "unprognostic (2.87e-2)" "unprognostic (2.53e-1)" "unprognostic (1.83e-2)" "unprognostic (4.77e-3)" "unprognostic (1.53e-2)" "unprognostic (3.27e-3)" "prognostic unfavorable (2.59e-4)" "unprognostic (1.87e-1)" "unprognostic (2.60e-3)" "unprognostic (6.54e-2)" "unprognostic (1.03e-1)" "unprognostic (2.81e-2)" "unprognostic (3.37e-3)" 16.0 0.9 7.3 7.3 7.2 1.4 12.3 8.5 7.3 21.3 2.4 24.9 19.8 17.3 4.4 13.5 23.4 8.3 13.0 4.9 6.3 41.3 1.4 25.5 1.5 9.1 7.2 2.3 23.3 1.7 4.2 17.4 8.9 6.9 30.0 1.8 8.8 8.0 4.3 2.6 10.2 8.0 4.1 6.2 73.3 3.0 8.1 2.0 5.7 12.0 5.3 30.4 7.5 6.3 25.8 0.7 0.9 0.2 3.7 2.7 1.1 3.7 4.2 1.1 2.2 10.7 26.1 0.9 39.1 0.6 5.5 13.4 10.2 15.7 3.1 1.4 16.6 16.7 7.6 1.1 0.4 0.3 5.1 5.7 2.2 1.0 12.1 12.0 55.5 1.4 13.0 1.8 10.3 9.8 0.9 0.4 1.7 13.5 6.6 9.8 13.1 0.3 71.2 119.6 1.0 3.1 1.3 6.7 0.3 1.5 7.1 1.1 53.4 9.7 6.6 2.5 16.9 1.4 0.7 0.9 4.8 1.0 1.6 0.9 0.4 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.5 0.2 0.0 0.0 0.3 0.4 0.5 1.6 0.1 0.0 7.3 7.2 8.5 7.3 4.9 6.3 9.1 7.2 8.9 4.1 8.1 6.3 80.2 60.9 184.8 16.0 0.6 2.2 33.3 29.4 10.2 0.0 1.2 0.9 11.4 2.8 69.6 125.0 0.0 1.1 0.1 25.5 52.8 1.6 10.4 71.9 5.8 70.5 19.9 7.4 10.3 75.4 0.2 4.8 111.1 107.7 9.5 0.8 69.3 0.2 0.0 0.0 9.1 29.0 20.3 0.6 1.9 3.2 0.3 2.6 1.8 346.6 1.0 0.0 0.0 6.0 13.8 49.8 19.3 0.0 0.3 13.9 6.2 0.7 53.2 0.1 0.0 1.4 5.7 3.0 1.2 39.4 1.4 0.4 1.3 0.5 53.9 45.4 MEF2B RSRFR2 ENSG00000213999 "Myocyte enhancer factor 2B" Q02080 19 19145567-19192131 "Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "lymphoid tissue: 39.3" "Cell type enriched" "Detected in some" 4 "Plasma cells: 29.3" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 10 "Daudi: 223.4;U-266/70: 217.6;U-698: 299.5" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA004734 Supported Approved "Nucleoplasm,Cell Junctions,Cytosol" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 16: Immune cells - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" "Nucleoplasm, Cytosol" "Cell Junctions" "HPA004734: AB_10963939" "unprognostic (7.31e-3)" "unprognostic (4.06e-2)" "unprognostic (9.44e-5)" "unprognostic (5.07e-2)" "unprognostic (2.01e-1)" "unprognostic (7.19e-3)" "unprognostic (1.64e-1)" "unprognostic (1.78e-1)" "unprognostic (2.76e-1)" "unprognostic (1.98e-2)" "unprognostic (8.66e-3)" "unprognostic (1.92e-2)" "unprognostic (1.56e-11)" "unprognostic (2.40e-1)" "unprognostic (1.92e-1)" "unprognostic (3.68e-1)" "unprognostic (8.98e-3)" 3.0 1.8 4.4 13.9 5.4 2.3 2.6 4.4 6.1 4.0 4.4 3.1 1.8 2.3 0.7 2.2 3.5 1.4 2.2 4.5 4.7 2.7 3.8 2.6 39.3 5.2 4.9 3.9 1.5 0.4 2.6 1.0 4.8 4.5 1.1 0.9 2.6 1.3 1.0 2.8 4.9 1.3 4.3 8.8 2.6 3.2 5.2 1.8 3.4 0.7 31.5 2.3 3.3 6.1 2.3 0.5 1.5 2.1 1.3 2.5 2.2 1.3 0.9 1.8 2.2 0.0 3.2 223.4 1.0 0.9 0.5 2.0 0.3 0.8 0.3 1.0 5.1 1.4 0.6 1.1 2.8 1.2 2.0 1.0 1.8 1.1 1.6 1.0 0.1 4.2 0.9 3.9 0.8 3.9 1.6 1.8 0.2 0.2 12.8 4.6 0.9 5.2 0.5 0.3 0.3 1.8 2.5 0.3 1.7 0.0 0.0 2.5 0.7 1.1 4.0 6.9 1.8 217.6 24.0 299.5 2.6 3.9 1.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 4.4 5.4 4.4 6.1 4.5 4.7 5.2 4.9 4.8 4.3 5.2 6.1 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 29.3 0.0 0.0 0.0 0.0 0.0 6.6 0.0 1.4 0.1 0.0 0.4 0.0 0.0 0.1 0.1 0.0 0.0 MEN1 ENSG00000133895 "Menin 1" O00255 11 64803510-64811294 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Transcription, Transcription regulation" "Chromatin regulator, DNA-binding, Repressor" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030342 Uncertain Supported Nucleoplasm,Cytosol NA NA "Cluster 37: B-cells - Transcription" "Cluster 18: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm Cytosol "HPA030342: AB_10610138" "unprognostic (2.06e-1)" "unprognostic (1.76e-1)" "unprognostic (3.78e-2)" "unprognostic (2.31e-2)" "unprognostic (1.05e-1)" "unprognostic (8.41e-2)" "prognostic unfavorable (1.08e-4)" "unprognostic (2.66e-1)" "unprognostic (2.59e-1)" "unprognostic (1.42e-2)" "unprognostic (4.96e-2)" "unprognostic (1.36e-1)" "unprognostic (7.39e-2)" "prognostic favorable (6.31e-5)" "unprognostic (1.40e-1)" "unprognostic (3.03e-1)" "unprognostic (3.76e-1)" 15.1 24.2 13.1 8.4 13.7 6.5 15.7 12.7 15.0 19.3 13.0 16.8 7.8 17.4 8.1 23.9 16.3 5.5 12.4 14.3 12.7 19.4 30.3 16.1 10.9 12.5 12.5 20.8 26.2 6.3 21.7 7.8 12.6 20.2 4.7 4.7 21.3 7.7 11.0 24.0 20.9 5.3 11.9 25.5 20.6 16.3 13.5 17.1 24.5 5.8 10.2 16.4 18.7 12.9 30.8 33.7 22.4 37.7 30.4 17.4 24.8 19.2 23.3 35.6 21.2 19.0 25.5 43.6 33.8 16.7 29.8 39.0 36.4 28.3 19.3 30.5 48.1 35.6 17.3 30.9 27.2 23.6 22.8 19.2 18.2 26.8 21.9 16.5 33.7 49.3 51.5 15.7 18.9 54.2 60.3 29.3 36.7 30.3 54.7 45.1 29.8 44.1 23.2 22.8 33.6 28.9 26.0 36.9 27.9 16.5 56.6 27.1 17.4 23.5 28.8 36.5 16.7 21.8 30.4 22.1 25.5 16.2 21.0 0.5 0.5 1.4 1.5 0.6 1.8 1.8 1.1 1.9 0.6 1.8 1.9 0.9 0.1 0.9 0.2 1.3 0.9 0.5 13.1 13.7 12.7 15.0 14.3 12.7 12.5 12.5 12.6 11.9 13.5 12.9 6.9 3.2 5.4 5.9 10.6 5.7 4.6 5.3 7.4 8.5 10.2 11.0 4.5 4.3 2.8 3.7 6.2 19.4 8.0 9.2 3.9 8.9 0.9 7.9 11.0 7.0 4.2 10.8 7.4 7.1 21.7 6.9 13.7 12.1 1.3 14.1 7.9 10.9 9.0 3.3 6.2 9.0 6.1 3.1 2.3 0.9 12.2 4.8 8.8 8.4 6.3 7.7 6.2 4.5 5.0 7.5 10.7 3.8 8.4 6.1 9.3 8.0 4.0 6.5 13.1 5.4 5.6 14.2 13.0 9.4 7.0 16.3 8.9 14.3 10.2 3.3 MET "DFNB97, HGFR, RCCP2" ENSG00000105976 "MET proto-oncogene, receptor tyrosine kinase" P08581 7 116672196-116798377 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Deafness, Disease variant, FDA approved drug targets, Non-syndromic deafness, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 42.9" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 103.6;Club cells: 99.8;Glandular and luminal cells: 161.4;Pancreatic endocrine cells: 93.9;Prostatic glandular cells: 149.3;Urothelial cells: 128.6" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in many" 5 "cerebral cortex: 7.5;hippocampal formation: 6.6;midbrain: 2.5;pons: 4.9;white matter: 7.8" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 203.8;CAPAN-2: 219.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB005282, CAB018577, HPA055607" Approved Approved "Plasma membrane,Cytosol" "Secreted to blood" NA NA 179000000 100000000 "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 44: Endometrium - Transcription" "Plasma membrane, Cytosol" "CAB005282: AB_631940, CAB018577: AB_649068, HPA055607: AB_2682860" "unprognostic (1.60e-2)" "unprognostic (7.71e-2)" "unprognostic (2.53e-2)" "unprognostic (1.58e-1)" "unprognostic (3.57e-3)" "prognostic unfavorable (6.75e-4)" "unprognostic (1.68e-1)" "unprognostic (3.22e-2)" "unprognostic (3.81e-2)" "unprognostic (2.52e-2)" "prognostic unfavorable (1.21e-7)" "unprognostic (1.86e-1)" "unprognostic (1.25e-1)" "unprognostic (5.53e-2)" "unprognostic (8.88e-2)" "unprognostic (2.01e-2)" "unprognostic (2.20e-1)" 10.3 0.8 0.1 3.4 0.6 7.4 8.9 0.1 7.5 13.1 9.6 9.7 6.5 6.4 2.5 6.1 4.7 11.9 6.2 6.6 0.8 20.1 42.9 20.3 2.3 1.1 2.5 0.8 6.6 0.8 3.8 26.4 4.9 6.7 9.3 3.9 8.7 11.2 14.3 7.7 8.2 5.7 0.3 6.0 15.4 0.5 0.5 3.7 17.6 11.0 3.2 18.4 4.4 7.8 203.8 115.3 0.1 0.6 8.6 8.7 7.9 113.7 48.2 60.3 51.1 25.0 219.0 8.4 179.0 72.1 163.3 51.8 19.7 110.0 123.7 0.3 23.4 0.1 112.5 21.4 1.5 0.3 0.2 11.4 42.4 40.6 129.1 109.4 42.4 0.2 4.5 0.8 114.1 5.0 0.1 0.1 17.3 32.9 113.0 0.2 95.3 0.2 105.8 24.0 16.5 0.0 45.4 15.4 44.9 19.8 0.4 0.9 72.3 89.7 30.6 46.7 88.9 2.5 19.1 1.5 99.3 0.3 12.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.1 7.5 6.6 0.8 1.1 2.5 4.9 0.3 0.5 7.8 32.6 28.9 103.6 0.3 1.0 39.0 70.5 58.1 38.1 6.7 6.5 6.9 12.3 11.5 99.8 31.3 0.0 76.0 0.4 20.5 0.0 38.5 0.0 52.5 11.6 20.1 7.2 0.0 2.6 46.9 7.5 7.4 32.6 161.4 0.0 0.0 3.9 30.5 7.0 0.0 1.0 20.5 18.3 1.3 2.2 0.1 0.6 4.4 3.6 1.9 1.0 7.6 0.0 0.5 7.7 93.9 5.5 0.0 0.4 149.3 11.2 15.6 34.5 0.3 0.0 37.8 5.2 0.0 0.6 7.9 17.8 21.8 1.2 0.0 16.4 128.6 MITF "bHLHe32, MI, WS2, WS2A" ENSG00000187098 "Melanocyte inducing transcription factor" O75030 3 69739464-69968336 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Developmental protein, DNA-binding" "Albinism, Cancer-related genes, Deafness, Disease variant, Microphthalmia, Osteopetrosis, Waardenburg syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Inhibitory neurons: 133.5;Melanocytes: 585.2;Oligodendrocyte precursor cells: 166.9;Oligodendrocytes: 240.3" "Cancer enriched" "Detected in all" 4 "melanoma: 39.2" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "basophil: 5.2;classical monocyte: 9.4;intermediate monocyte: 3.3;myeloid DC: 6.1;non-classical monocyte: 5.9" "Group enriched" "Detected in many" 6 "dendritic cells: 6.1;granulocytes: 5.2;monocytes: 9.4" "Cell line enhanced" "Detected in many" "HMC-1: 89.1;SK-MEL-30: 254.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002578, HPA003259" Enhanced NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB002578: AB_564111, HPA003259: AB_1079381" "unprognostic (3.29e-1)" "unprognostic (4.26e-2)" "unprognostic (2.98e-2)" "unprognostic (6.04e-2)" "unprognostic (1.03e-1)" "unprognostic (3.25e-1)" "unprognostic (1.04e-2)" "unprognostic (1.09e-1)" "unprognostic (2.75e-1)" "unprognostic (5.31e-3)" "unprognostic (3.87e-3)" "unprognostic (1.94e-1)" "prognostic favorable (8.35e-10)" "unprognostic (6.37e-2)" "unprognostic (1.08e-1)" "unprognostic (2.04e-1)" "unprognostic (1.73e-1)" 13.8 4.4 5.1 3.8 9.2 1.7 10.0 9.4 6.3 51.3 21.2 18.8 2.8 46.2 4.5 8.9 10.3 16.8 31.1 5.2 9.3 20.0 2.2 9.7 3.4 12.5 9.5 18.7 4.2 16.8 3.8 3.3 10.4 8.4 4.5 1.2 5.1 14.1 50.6 11.0 5.8 46.0 7.0 2.0 9.4 2.3 10.3 2.2 7.6 43.3 1.5 10.6 16.6 13.8 17.2 12.2 1.3 5.1 18.8 0.3 2.0 16.9 9.9 7.8 4.8 6.1 0.8 0.0 4.0 0.3 21.6 8.6 3.7 9.4 8.6 0.0 2.5 37.1 24.5 0.3 4.5 0.8 89.1 15.3 3.9 2.2 8.6 29.1 2.4 0.0 12.3 5.2 5.4 1.2 0.7 1.0 0.7 0.7 8.3 0.1 1.9 7.7 45.2 9.0 0.4 1.9 8.8 3.1 254.1 2.0 0.7 2.3 0.1 3.8 13.3 5.1 3.5 0.6 1.0 0.1 7.7 2.6 9.2 5.2 9.4 0.0 0.0 3.3 0.0 0.0 0.0 0.1 6.1 0.0 0.0 0.0 0.7 1.1 5.9 0.5 0.0 3.1 5.1 9.2 9.4 6.3 5.2 9.3 12.5 9.5 10.4 7.0 10.3 13.8 4.6 28.9 6.8 34.3 0.2 42.8 3.6 16.7 7.4 1.6 1.8 1.8 109.5 11.5 18.2 14.7 0.0 1.3 0.6 0.4 50.9 14.7 1.6 24.5 94.3 7.4 1.2 8.6 14.7 8.8 1.0 38.3 9.7 71.2 106.8 10.9 4.6 2.1 45.8 6.7 133.5 0.3 12.2 30.8 30.9 3.4 44.4 24.3 585.2 50.6 10.6 1.4 0.0 166.9 240.3 7.7 0.0 50.4 0.4 5.2 0.2 24.3 12.5 0.2 13.1 17.8 22.6 4.0 6.3 7.2 18.9 1.1 3.8 5.5 0.6 7.1 MLH1 "COCA2, FCC2, HNPCC, HNPCC2" ENSG00000076242 "MutL homolog 1" P40692 3 36993350-37050846 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cell cycle, DNA damage, DNA repair" "Cancer-related genes, Disease variant, Hereditary nonpolyposis colorectal cancer, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013294, HPA052707, HPA060714, CAB070868" Supported Enhanced Nucleoplasm NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm "CAB013294: AB_2533406, CAB070868: , HPA052707: AB_2681923, HPA060714: AB_2684348" "unprognostic (1.26e-2)" "unprognostic (3.88e-3)" "unprognostic (2.36e-2)" "unprognostic (1.82e-1)" "unprognostic (3.33e-2)" "unprognostic (1.05e-1)" "prognostic unfavorable (8.24e-5)" "unprognostic (3.36e-2)" "unprognostic (2.18e-1)" "unprognostic (1.32e-1)" "unprognostic (8.54e-2)" "unprognostic (8.63e-3)" "unprognostic (2.10e-3)" "unprognostic (4.37e-2)" "unprognostic (1.38e-1)" "unprognostic (1.02e-2)" "unprognostic (8.86e-2)" 15.6 17.9 7.3 17.4 8.0 22.1 15.4 7.1 9.1 17.4 7.6 17.4 12.0 16.3 14.0 14.3 14.9 11.1 35.4 6.9 8.3 16.0 19.1 15.8 21.9 8.6 7.4 15.1 16.6 22.4 22.7 14.8 7.6 16.2 14.5 9.6 12.1 14.0 49.1 13.4 13.4 19.2 7.1 18.8 15.5 25.4 7.7 28.4 19.2 42.2 24.3 17.2 14.0 9.0 37.1 56.7 66.7 0.2 25.9 34.5 30.7 54.7 44.4 64.1 62.3 43.4 40.1 92.2 25.0 44.1 33.6 24.7 65.2 45.8 68.5 42.2 32.1 68.1 42.3 54.9 23.2 81.9 40.5 28.4 29.0 54.8 57.8 21.9 37.6 55.0 86.0 32.0 66.2 27.6 81.0 22.2 49.4 38.4 31.6 4.6 90.6 40.2 35.1 39.3 14.2 36.1 52.1 56.9 32.7 33.3 79.9 55.6 28.8 46.0 50.5 44.0 65.9 29.1 93.7 88.1 37.8 71.9 45.7 12.6 12.5 15.1 12.7 22.6 9.8 11.3 7.7 11.4 14.3 9.7 8.4 9.6 2.6 7.8 29.2 5.9 15.0 11.0 7.3 8.0 7.1 9.1 6.9 8.3 8.6 7.4 7.6 7.1 7.7 9.0 10.8 25.6 15.8 22.9 18.5 7.1 12.4 18.7 7.4 18.5 9.6 9.7 41.8 12.8 15.8 11.0 10.4 33.4 16.0 6.1 19.6 14.6 31.3 12.5 11.3 10.7 5.4 19.0 18.5 14.7 26.9 14.4 12.2 9.5 7.6 13.0 13.6 14.9 20.1 3.3 21.6 8.6 16.2 16.3 8.9 13.2 11.1 13.8 8.8 10.3 18.2 15.9 11.3 27.2 31.3 9.3 7.4 13.9 22.1 6.4 5.3 12.9 16.5 18.1 13.1 10.0 14.0 58.6 29.3 9.3 5.5 20.0 15.9 14.8 8.4 6.5 MLLT10 AF10 ENSG00000078403 "MLLT10 histone lysine methyltransferase DOT1L cofactor" P55197 10 21524646-21743630 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Transcription, Transcription regulation" DNA-binding "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 93.0" "Cell type enhanced" "Detected in all" "Excitatory neurons: 201.3;Spermatocytes: 233.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005736, HPA005747, HPA072790" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 1: K-562 - Erythropoiesis" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm Cytosol "HPA005736: , HPA005747: AB_1079393, HPA072790: " "unprognostic (6.58e-2)" "unprognostic (1.57e-1)" "unprognostic (7.32e-2)" "unprognostic (1.47e-2)" "unprognostic (1.31e-2)" "prognostic favorable (8.75e-4)" "unprognostic (1.03e-3)" "unprognostic (9.56e-3)" "unprognostic (9.29e-2)" "unprognostic (1.78e-1)" "unprognostic (2.69e-2)" "unprognostic (7.85e-2)" "unprognostic (6.57e-2)" "unprognostic (1.26e-1)" "unprognostic (1.50e-1)" "unprognostic (1.07e-1)" "unprognostic (1.67e-1)" 15.6 13.0 11.9 12.0 13.6 30.5 14.4 21.5 16.0 18.2 16.6 20.8 9.1 18.7 16.0 16.1 17.4 11.4 17.1 11.5 15.2 15.1 15.6 14.6 15.3 14.6 11.9 24.7 13.5 18.6 12.6 16.4 14.1 13.0 12.7 20.6 13.7 11.8 15.6 25.4 13.2 16.8 11.9 12.8 12.3 93.0 13.7 23.2 21.8 14.2 14.5 19.1 16.5 18.6 32.1 29.6 38.3 22.2 23.3 25.0 44.1 19.6 10.6 21.7 21.6 29.5 31.3 34.9 10.8 20.7 21.1 24.1 43.3 25.1 22.2 25.0 21.9 59.2 24.5 44.5 29.6 1.6 33.4 21.3 28.6 17.7 19.2 21.8 30.1 34.3 65.4 26.5 19.3 28.1 44.1 28.5 17.3 17.5 9.2 36.6 23.5 31.7 23.2 12.6 13.8 39.6 24.7 29.0 45.8 30.7 13.3 37.1 29.8 14.7 24.6 26.7 18.9 23.5 32.2 43.4 15.4 21.5 9.9 10.3 6.5 13.5 5.0 4.1 4.6 5.3 6.1 6.1 5.1 4.3 6.6 6.0 4.8 4.6 4.7 7.5 5.5 2.5 11.9 13.6 21.5 16.0 11.5 15.2 14.6 11.9 14.1 11.9 13.7 18.6 33.3 28.9 40.4 155.7 25.1 37.7 17.4 22.4 44.3 38.4 19.9 20.7 31.5 18.6 19.6 18.4 43.8 34.0 24.9 13.3 13.7 14.6 66.1 16.1 26.6 28.7 3.5 30.9 201.3 12.8 58.6 26.6 21.9 21.3 25.2 28.6 26.0 22.7 28.9 30.3 169.6 16.3 26.4 36.1 23.0 109.0 39.4 28.6 48.0 107.7 29.7 17.8 21.6 148.3 160.0 13.2 14.6 48.2 23.5 22.7 18.8 23.1 18.7 53.7 39.5 31.4 35.7 233.8 57.4 48.5 43.9 50.2 29.5 24.2 18.0 13.5 MMP1 CLG ENSG00000196611 "Matrix metallopeptidase 1" P03956 11 102789401-102798160 "Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Collagen degradation, Host-virus interaction" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 75.7;stomach 1: 47.6;urinary bladder: 52.2" "Cell type enriched" "Detected in many" 10 "Pancreatic endocrine cells: 2239.5" "Cancer enhanced" "Detected in many" "head and neck cancer: 344.2" "Region enriched" "Detected in single" 7 "cerebral cortex: 1.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ hTERT+: 1139.1;HBF TERT88: 1094.4;HUVEC TERT2: 2954.4;WM-115: 1454.1" "Not detected" "Not detected" HPA004920 Approved Vesicles "Secreted to extracellular matrix" NA NA 7730000 55000 "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 17: WM-115 - Nervous system development" "Cluster 16: Pancreatic endocrine cells - Mixed function" Vesicles "HPA004920: AB_2667293" "unprognostic (4.11e-3)" "prognostic unfavorable (4.66e-4)" "unprognostic (4.20e-3)" "unprognostic (1.19e-3)" "unprognostic (6.46e-2)" "unprognostic (6.50e-2)" "prognostic unfavorable (4.22e-6)" "unprognostic (7.83e-3)" "unprognostic (2.94e-2)" "unprognostic (5.44e-2)" "unprognostic (1.11e-3)" "unprognostic (1.75e-1)" "prognostic unfavorable (9.86e-10)" "unprognostic (1.67e-2)" "unprognostic (1.49e-1)" "unprognostic (1.26e-2)" "unprognostic (5.11e-2)" 0.3 0.1 0.0 26.7 0.0 0.3 0.2 0.0 1.3 0.1 0.0 6.1 7.9 10.7 0.0 4.2 0.1 75.7 0.4 0.0 0.1 1.0 0.8 6.7 0.1 0.0 0.0 0.0 1.8 0.0 0.1 7.2 0.0 0.4 6.8 0.0 6.9 0.2 0.0 0.6 13.0 1.2 0.0 2.1 47.6 0.1 0.1 0.3 0.2 0.0 1.7 52.2 0.2 0.0 0.0 0.0 0.0 1.0 0.0 1.1 0.0 517.1 1139.1 456.6 118.2 9.1 1.0 0.0 5.2 275.5 175.2 4.6 0.0 160.0 1094.4 0.0 1.0 0.0 0.0 0.0 2.9 0.0 0.5 0.3 0.8 470.1 39.6 0.1 2954.4 0.0 1.5 0.5 0.3 0.0 0.0 0.0 0.4 189.3 20.8 0.0 0.1 0.0 0.7 2.2 0.0 0.1 4.8 0.0 1.6 0.1 0.5 0.0 155.0 374.1 0.6 16.8 1.3 0.1 0.0 0.0 8.8 0.0 1454.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.3 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 1.3 3.2 2.6 0.0 0.2 2.3 22.4 90.4 0.0 0.0 0.0 0.0 0.1 30.0 15.8 3.7 0.0 0.0 0.0 0.2 0.0 143.7 0.0 0.1 0.2 113.2 0.0 0.0 0.1 204.8 0.1 11.5 25.5 2.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 2.0 1.9 0.4 0.0 0.0 15.5 0.0 0.0 4.2 0.0 0.0 0.0 0.0 2239.5 1.2 0.0 0.0 30.9 0.7 0.2 1.3 0.0 0.0 1.8 10.5 0.0 0.0 0.0 0.3 0.1 0.1 0.1 0.1 44.3 MMP2 "CLG4, CLG4A, TBE-1" ENSG00000087245 "Matrix metallopeptidase 2" P08253 16 55389700-55506691 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Angiogenesis, Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "gallbladder: 1062.9" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 222.4;Extravillous trophoblasts: 467.9;Fibroblasts: 815.9;Leydig cells: 340.2;Peritubular cells: 419.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 5619.3;ASC TERT1: 1623.2;hTERT-RPE1: 6400.4;U-87 MG: 1812.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA001939, CAB002788" Approved Approved Vesicles "Secreted to extracellular matrix" NA NA 1600000000 220000000 "Cluster 46: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" Vesicles "CAB002788: , HPA001939: AB_1079395" "unprognostic (7.26e-2)" "unprognostic (1.36e-3)" "unprognostic (1.66e-1)" "unprognostic (2.14e-3)" "unprognostic (5.03e-2)" "unprognostic (1.20e-1)" "unprognostic (1.74e-1)" "unprognostic (9.36e-3)" "unprognostic (4.81e-3)" "unprognostic (3.79e-2)" "unprognostic (4.59e-3)" "unprognostic (6.12e-2)" "unprognostic (1.28e-3)" "unprognostic (1.59e-2)" "unprognostic (8.00e-2)" "unprognostic (8.98e-2)" "unprognostic (4.63e-2)" 518.9 68.3 3.9 135.1 4.0 1.2 328.9 4.9 7.8 514.1 9.4 173.8 57.4 453.6 192.6 121.5 190.6 1062.9 212.8 3.6 5.3 43.7 15.6 279.7 28.1 7.6 4.9 271.1 42.8 13.8 14.7 225.0 5.4 116.8 171.3 11.4 124.1 137.5 60.8 455.6 177.3 468.5 6.7 58.3 134.0 49.6 8.6 19.8 113.5 66.1 30.3 660.8 238.1 10.0 6.5 3.9 192.0 2.4 5619.3 1623.2 312.7 501.4 1146.1 99.4 79.0 0.2 2.1 0.5 391.7 891.0 37.0 54.2 1.2 4.6 57.0 0.7 0.9 0.7 12.9 3.0 530.6 0.4 14.8 1396.8 1.7 512.4 4.4 6400.4 651.1 0.5 0.7 2.4 334.7 0.0 0.4 8.2 152.4 0.5 1.6 0.4 46.1 0.9 16.1 7.6 3.2 345.0 93.3 0.8 2.1 849.0 1.6 36.0 924.6 1546.0 144.9 300.5 66.9 1.0 0.6 2.2 1812.3 28.3 289.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.9 4.0 4.9 7.8 3.6 5.3 7.6 4.9 5.4 6.7 8.6 10.0 38.4 0.0 0.5 0.0 0.0 122.1 14.1 48.8 9.1 30.5 3.1 16.8 4.4 0.0 3.1 11.0 0.0 5.6 0.5 0.1 0.0 2.5 12.5 7.7 222.4 46.9 28.2 0.0 0.0 0.4 467.9 815.9 12.2 5.4 0.0 0.0 13.2 0.1 28.2 1.7 0.2 0.1 2.0 1.6 180.7 40.2 340.2 11.8 128.1 27.2 0.0 7.7 0.0 5.0 0.0 9.3 0.0 419.0 2.8 5.6 0.0 0.2 1.1 2.5 13.1 80.0 65.3 1.2 2.8 6.6 102.3 17.2 10.3 35.2 0.0 4.4 MMP9 CLG4B ENSG00000100985 "Matrix metallopeptidase 9" P14780 20 46008908-46016561 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 11 "bone marrow: 376.0;lymphoid tissue: 105.3" "Group enriched" "Detected in many" 5 "Hofbauer cells: 260.1;Langerhans cells: 606.0;Macrophages: 230.6" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in some" 4 "cerebral cortex: 3.1;thalamus: 4.8" "Immune cell enriched" "Detected in some" 127 "neutrophil: 272.2" "Lineage enriched" "Detected in single" 341 "granulocytes: 272.2" "Cell line enriched" "Detected in some" 13 "NB-4: 360.6" "Low region specificity" "Detected in many" "Not detected" "Not detected" "CAB000348, HPA001238, HPA063909, CAB068199, CAB068200, CAB068201" Enhanced Approved Cytosol "Secreted to blood" NA NA 43300000 61000000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 24: NB-4 - Immune response" "Cluster 4: Macrophages - Innate immune response" Cytosol "CAB000348: , CAB068199: AB_2665675, CAB068200: AB_2665676, CAB068201: AB_2665677, HPA001238: AB_1079398, HPA063909: AB_2685150" "unprognostic (4.62e-2)" "unprognostic (1.64e-1)" "unprognostic (2.85e-2)" "prognostic favorable (2.55e-4)" "unprognostic (6.65e-3)" "unprognostic (2.82e-1)" "prognostic unfavorable (7.19e-4)" "unprognostic (1.54e-1)" "unprognostic (8.57e-2)" "unprognostic (3.21e-2)" "unprognostic (4.15e-2)" "unprognostic (1.96e-1)" "prognostic unfavorable (4.05e-5)" "unprognostic (4.65e-1)" "unprognostic (9.85e-3)" "unprognostic (2.48e-2)" "unprognostic (2.17e-3)" 19.5 0.6 0.5 61.9 0.8 376.0 8.2 0.4 3.1 2.9 0.8 5.7 11.6 1.0 0.0 2.2 2.2 3.0 3.2 0.3 0.9 2.6 3.8 21.1 103.2 0.8 0.5 0.8 1.6 0.1 1.1 2.0 0.7 1.9 3.4 0.6 3.6 0.4 0.7 3.2 12.4 1.9 0.4 105.3 11.3 1.3 4.8 17.0 2.1 0.9 36.5 12.0 1.1 0.2 0.2 0.4 0.2 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 3.3 0.3 28.8 0.0 0.3 0.4 0.0 1.4 0.0 0.3 0.5 0.1 0.0 0.0 0.0 0.6 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.4 0.0 4.0 0.0 360.6 0.8 0.0 0.2 0.4 0.3 0.1 0.0 0.0 0.6 0.6 0.0 0.6 0.0 3.7 0.3 1.2 0.3 10.3 10.9 0.1 0.3 0.3 0.2 0.2 0.1 0.8 0.2 0.0 0.7 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 272.2 0.0 0.3 0.0 0.0 0.5 0.5 0.8 0.4 3.1 0.3 0.9 0.8 0.5 0.7 0.4 4.8 0.2 0.7 0.0 5.5 0.0 3.9 34.3 0.1 61.5 0.0 3.8 0.5 2.0 0.4 1.5 0.9 0.0 8.4 1.5 2.0 0.0 0.0 0.8 0.9 0.0 0.1 7.2 0.0 0.0 0.1 1.8 2.4 2.5 0.0 0.1 1.3 0.2 0.0 0.0 260.1 3.3 0.2 0.5 0.0 1.3 606.0 0.3 0.0 230.6 56.9 0.0 2.3 1.2 0.0 0.0 0.0 1.8 0.0 0.0 0.9 0.1 0.0 0.3 6.9 5.3 0.0 0.2 45.5 6.7 11.2 0.2 28.1 1.9 3.4 0.3 0.0 0.1 MPL "CD110, THPOR, TPOR" ENSG00000117400 "MPL proto-oncogene, thrombopoietin receptor" P40238 1 43337818-43354466 "Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" Receptor "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in some" "Group enriched" "Detected in some" 5 "Erythroid cells: 3.0;Excitatory neurons: 2.0;Oligodendrocytes: 1.0" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in single" "neutrophil: 1.4" "Lineage enriched" "Detected in single" 4 "granulocytes: 1.4" "Cell line enriched" "Detected in some" 57 "HEL: 77.4" "Region enhanced" "Detected in single" "cerebral cortex: 1.5" "Low region specificity" "Detected in many" HPA007619 Supported "Nuclear membrane,Plasma membrane" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 36: HEL - Hemostasis" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" "Nuclear membrane" "HPA007619: AB_1854080" "unprognostic (2.74e-1)" "unprognostic (6.56e-2)" "unprognostic (2.95e-1)" "unprognostic (8.71e-2)" "unprognostic (1.37e-2)" "unprognostic (1.06e-3)" "unprognostic (1.19e-1)" "unprognostic (1.22e-2)" "unprognostic (5.83e-2)" "unprognostic (1.03e-1)" "unprognostic (5.94e-4)" "unprognostic (1.51e-1)" "unprognostic (1.19e-4)" "unprognostic (2.39e-1)" "unprognostic (3.26e-1)" "unprognostic (1.03e-4)" "unprognostic (1.42e-1)" 0.6 0.4 0.8 0.2 1.7 1.8 0.4 0.8 1.3 0.3 0.1 0.3 0.3 0.7 1.2 0.5 0.8 0.3 1.0 0.6 1.2 0.4 0.4 0.6 0.2 1.2 1.0 2.9 0.8 0.4 0.0 0.3 1.1 0.9 0.4 1.5 0.4 0.7 0.6 0.5 0.2 0.7 0.7 0.4 0.5 1.2 1.1 0.1 0.9 0.3 0.1 0.2 0.0 2.8 0.4 0.7 0.1 0.2 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.7 1.3 0.1 0.3 0.1 0.0 0.6 0.0 0.2 0.0 0.4 0.1 77.4 1.2 0.4 0.0 0.1 0.0 0.0 0.2 0.0 0.2 0.3 0.0 0.1 0.0 0.1 0.0 0.3 0.0 0.2 0.5 0.1 0.1 0.2 0.0 0.2 0.7 0.6 0.4 0.2 0.6 0.1 0.2 0.2 0.3 0.0 0.1 0.1 0.2 0.1 0.1 0.2 0.2 0.0 0.0 0.0 0.0 0.9 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.0 0.0 0.2 0.2 0.2 1.4 0.1 0.1 0.3 0.1 1.8 0.8 1.7 0.8 1.3 0.6 1.2 1.2 1.0 1.1 0.7 1.1 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 3.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 MSH2 "COCA1, HNPCC, HNPCC1" ENSG00000095002 "MutS homolog 2" P43246 2 47403067-47663146 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair" DNA-binding "Cancer-related genes, Disease variant, Hereditary nonpolyposis colorectal cancer, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Cancer enhanced" "Detected in all" "testis cancer: 46.2" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009572, HPA066845, CAB070867" Approved Supported Nucleoplasm,Vesicles NA Yes 28000 "Cluster 48: NK-cells - Unknown function" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm Vesicles "CAB009572: AB_2144828, CAB070867: , HPA066845: AB_2732752" "unprognostic (2.35e-1)" "unprognostic (1.54e-2)" "unprognostic (2.89e-3)" "prognostic unfavorable (4.44e-4)" "unprognostic (2.23e-1)" "unprognostic (6.31e-3)" "prognostic unfavorable (1.72e-9)" "unprognostic (1.77e-1)" "unprognostic (7.09e-3)" "unprognostic (8.57e-2)" "prognostic unfavorable (4.63e-4)" "unprognostic (5.38e-2)" "unprognostic (3.29e-3)" "unprognostic (1.20e-3)" "unprognostic (5.74e-1)" "unprognostic (8.46e-2)" "unprognostic (1.48e-1)" 8.1 7.5 8.3 12.8 10.5 15.7 15.7 14.6 10.6 9.7 12.2 11.9 7.8 11.7 14.0 9.5 12.4 5.8 10.1 9.6 9.0 8.2 6.7 8.1 23.7 8.6 8.0 8.7 6.5 14.8 6.2 11.6 9.5 8.6 15.0 34.9 8.5 7.7 7.1 11.1 9.3 8.8 8.5 10.8 8.1 16.2 7.9 32.6 15.8 7.2 25.0 7.9 6.4 8.9 114.3 35.3 103.3 57.9 7.3 21.2 64.3 62.9 33.3 80.9 76.9 72.3 50.1 141.2 84.6 23.8 56.6 49.8 78.6 37.4 122.3 68.1 55.8 99.3 42.3 65.6 7.7 97.7 34.9 12.3 11.2 68.1 19.0 19.1 45.2 3.9 165.1 34.0 63.1 44.2 119.6 75.4 195.7 69.3 45.1 151.1 182.2 84.4 35.8 57.3 85.9 91.6 58.4 49.2 48.0 83.6 46.9 38.8 18.7 55.5 70.9 57.1 74.6 20.8 63.4 180.1 33.1 72.5 35.4 3.0 1.3 4.9 8.0 4.4 9.3 6.7 7.7 10.3 2.5 7.9 12.6 13.1 1.0 14.2 3.9 3.4 11.8 6.5 8.3 10.5 14.6 10.6 9.6 9.0 8.6 8.0 9.5 8.5 7.9 8.9 14.7 9.6 11.5 18.6 13.0 8.3 7.9 14.4 8.6 17.4 7.5 7.1 15.6 5.7 12.6 9.2 45.9 19.9 14.2 6.6 3.9 11.5 17.8 21.0 11.3 13.4 3.5 54.1 59.9 8.4 20.7 12.2 7.1 18.8 12.0 28.2 5.0 1.6 11.4 11.8 58.0 12.1 14.2 4.1 4.6 22.8 5.3 5.1 8.8 16.9 5.5 22.6 17.5 35.7 54.7 7.3 5.0 6.4 12.4 2.8 5.4 4.5 23.3 41.1 0.0 9.8 9.0 56.5 50.8 9.3 6.5 5.1 12.8 24.3 13.5 3.8 MSH3 "DUP, MRP1" ENSG00000113318 "MutS homolog 3" P20585 5 80654652-80876815 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair" DNA-binding "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 95.1;Inhibitory neurons: 98.9;Oligodendrocytes: 92.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036081 Approved "Nuclear bodies" "Intracellular and membrane" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nuclear bodies" "HPA036081: AB_10673229" "unprognostic (1.91e-1)" "unprognostic (7.61e-2)" "prognostic favorable (5.90e-5)" "unprognostic (2.95e-2)" "unprognostic (1.89e-1)" "unprognostic (6.41e-2)" "unprognostic (1.81e-1)" "unprognostic (8.70e-2)" "unprognostic (3.17e-2)" "unprognostic (2.62e-2)" "unprognostic (2.63e-1)" "unprognostic (3.91e-1)" "prognostic favorable (1.77e-4)" "unprognostic (5.15e-3)" "unprognostic (1.46e-1)" "unprognostic (1.15e-2)" "unprognostic (1.29e-1)" 9.4 4.6 1.8 4.3 2.4 5.0 5.5 1.6 2.0 6.6 1.5 6.0 6.0 5.2 5.3 5.0 7.0 5.7 4.9 1.7 2.0 12.5 11.4 4.2 4.9 1.7 2.0 5.3 5.2 8.8 3.3 4.3 1.7 5.2 6.2 3.7 4.5 5.2 5.1 5.1 5.6 5.1 2.2 4.1 5.0 3.9 2.5 7.1 10.8 4.7 6.1 6.3 3.9 2.0 12.4 15.0 11.7 13.1 6.6 12.3 16.6 12.2 11.8 13.6 16.7 10.0 15.6 22.2 14.0 15.3 12.8 10.4 15.6 20.5 17.3 14.2 13.9 8.4 13.4 9.9 6.8 9.9 8.5 10.9 9.5 15.8 16.6 13.8 12.9 7.9 12.1 12.9 16.1 11.9 19.0 4.7 9.0 4.8 7.7 13.2 24.2 16.4 15.2 13.0 11.6 13.9 10.4 11.5 13.0 14.4 15.2 9.4 12.4 7.8 9.5 6.2 23.0 8.7 15.6 21.6 12.2 16.8 10.2 0.7 2.9 1.9 3.3 3.4 3.8 3.4 3.5 3.6 3.3 2.2 2.6 2.6 1.7 3.1 4.6 2.8 4.8 2.4 1.8 2.4 1.6 2.0 1.7 2.0 1.7 2.0 1.7 2.2 2.5 2.0 16.7 35.3 9.3 66.9 18.1 10.5 12.3 12.4 12.5 25.8 19.4 12.8 17.6 8.6 14.3 14.7 14.6 18.9 18.7 18.2 15.6 12.4 14.6 28.4 20.2 12.0 14.5 17.0 95.1 10.3 12.9 15.9 31.6 18.9 8.2 19.9 10.0 20.1 11.5 21.9 98.9 13.2 8.2 13.0 7.0 17.2 13.7 16.3 3.6 72.1 19.9 22.5 19.6 71.9 92.3 10.6 9.6 25.9 22.0 6.5 16.8 43.6 65.4 28.3 19.7 20.2 14.7 24.7 25.5 22.3 10.1 13.1 25.4 14.7 17.4 10.7 MSH6 GTBP ENSG00000116062 "MutS homolog 6" P52701 2 47695530-47810063 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Host-virus interaction" DNA-binding "Cancer-related genes, Disease variant, Hereditary nonpolyposis colorectal cancer" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Granulosa cells: 119.6;Theca cells: 114.9" "Cancer enhanced" "Detected in all" "testis cancer: 31.8" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009091, HPA028376, HPA028446, CAB070870" Enhanced Supported "Nucleoplasm,Golgi apparatus,Vesicles" NA Yes 15000 "Cluster 44: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "Golgi apparatus, Vesicles" "CAB009091: AB_670083, CAB070870: AB_2144959, HPA028376: AB_10598909, HPA028446: AB_10602182" "unprognostic (5.10e-2)" "unprognostic (5.87e-3)" "unprognostic (3.29e-2)" "prognostic unfavorable (1.34e-4)" "unprognostic (1.98e-1)" "unprognostic (3.09e-2)" "prognostic unfavorable (7.86e-4)" "unprognostic (1.79e-1)" "unprognostic (2.35e-3)" "unprognostic (1.01e-1)" "unprognostic (1.74e-3)" "unprognostic (8.99e-2)" "prognostic unfavorable (1.06e-7)" "unprognostic (1.22e-1)" "unprognostic (2.31e-1)" "unprognostic (9.68e-2)" "unprognostic (3.48e-2)" 11.7 22.7 9.3 17.7 13.7 24.0 16.2 15.0 12.7 15.5 12.7 13.0 9.0 27.7 10.2 11.7 17.8 10.9 9.3 8.9 11.5 12.1 19.8 11.6 28.4 12.7 11.7 53.0 31.3 17.0 9.8 20.3 13.0 15.0 12.4 21.6 10.8 15.6 10.5 13.1 9.8 27.2 10.7 12.7 10.9 35.3 11.3 36.3 17.2 11.2 31.0 12.8 12.2 19.9 116.5 77.6 128.4 37.5 42.3 46.3 67.9 63.6 51.1 60.2 59.8 67.2 41.4 158.1 84.5 59.5 82.0 46.0 130.3 74.3 82.1 80.7 69.0 117.0 60.8 71.1 28.8 131.5 37.8 38.6 28.3 60.7 41.6 53.8 40.8 5.3 115.9 69.8 61.8 85.5 144.2 80.1 130.7 81.3 37.7 219.6 204.3 84.7 44.5 76.2 92.8 100.3 79.1 40.4 42.7 124.3 54.6 42.6 33.4 72.2 92.3 54.6 80.6 63.8 79.3 276.2 61.9 77.9 42.4 7.7 3.7 3.8 4.8 6.2 5.5 4.3 5.5 5.0 5.5 4.2 8.4 4.5 2.5 5.9 6.4 2.7 5.3 3.6 9.3 13.7 15.0 12.7 8.9 11.5 12.7 11.7 13.0 10.7 11.3 19.9 19.8 28.9 21.4 5.9 19.2 25.2 22.0 12.3 31.9 25.4 14.4 15.1 8.6 2.8 21.8 7.3 35.5 35.6 20.7 7.4 3.9 15.7 46.4 27.1 31.1 18.4 4.8 47.1 8.5 9.6 21.8 24.0 8.6 31.7 17.7 119.6 13.6 10.2 13.0 15.2 12.1 9.7 20.3 5.6 13.2 17.5 25.4 16.8 3.6 7.5 10.0 22.7 8.2 9.5 27.4 9.1 3.7 22.6 31.1 16.1 2.6 6.7 22.1 31.4 6.6 27.4 33.0 54.3 48.8 22.0 17.5 9.6 19.8 114.9 12.1 11.7 MYB c-myb ENSG00000118513 "MYB proto-oncogene, transcription factor" P10242 6 135181308-135219173 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "bone marrow: 35.2;breast: 20.1;intestine: 26.5;lymphoid tissue: 66.1" "Cell type enhanced" "Detected in many" "Breast glandular cells: 47.8;Erythroid cells: 83.2;granulocytes: 26.0;Intestinal goblet cells: 32.7;Ionocytes: 26.4;Respiratory ciliated cells: 37.2;Undifferentiated cells: 52.0" "Group enriched" "Detected in many" 5 "breast cancer: 17.7;colorectal cancer: 16.4;stomach cancer: 5.6" "Low region specificity" "Detected in some" "Group enriched" "Detected in some" 5 "basophil: 4.6;eosinophil: 5.4;plasmacytoid DC: 1.5" "Group enriched" "Detected in many" 5 "dendritic cells: 1.5;granulocytes: 5.4" "Cell line enhanced" "Detected in many" "HL-60: 219.8;MOLT-4: 403.1;NB-4: 208.5;REH: 244.9;THP-1: 343.8;U-937: 186.1" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB017704, HPA071605" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 46: Basophils - DNA binding" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm Cytosol "CAB017704: , HPA071605: " "unprognostic (1.69e-1)" "unprognostic (5.82e-2)" "unprognostic (1.82e-3)" "unprognostic (1.37e-2)" "unprognostic (4.06e-1)" "unprognostic (8.35e-3)" "unprognostic (1.13e-3)" "unprognostic (2.48e-2)" "unprognostic (6.44e-2)" "unprognostic (1.00e-1)" "unprognostic (3.71e-2)" "prognostic favorable (9.65e-4)" "unprognostic (2.41e-11)" "prognostic favorable (9.87e-4)" "unprognostic (8.35e-2)" "unprognostic (3.04e-2)" "unprognostic (9.40e-2)" 0.3 0.5 1.6 5.3 1.7 35.2 20.1 0.0 0.7 1.6 0.4 25.3 10.9 1.0 0.1 3.0 8.4 0.9 0.1 0.3 0.2 0.1 0.4 2.0 6.3 0.9 1.0 0.0 0.3 3.6 0.0 0.4 0.6 1.4 26.5 0.3 0.6 0.9 0.1 3.0 9.4 1.4 0.2 1.2 2.0 0.7 0.3 66.1 0.1 0.0 7.0 1.1 1.3 0.1 1.8 0.3 1.9 3.0 0.0 0.1 0.3 1.0 0.6 1.1 1.1 0.3 1.4 10.9 0.4 0.3 0.4 0.9 5.6 0.0 0.7 18.0 2.5 138.8 1.0 0.5 0.1 219.8 105.1 0.0 0.1 0.6 0.0 0.5 0.3 133.4 114.6 20.1 1.1 11.6 403.1 208.5 1.5 19.2 1.7 244.9 5.9 33.2 0.3 1.5 10.5 6.9 0.5 10.4 0.6 0.5 7.9 343.8 0.4 0.3 1.6 7.9 2.4 27.7 7.7 66.0 0.1 186.1 2.3 4.6 0.7 5.4 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 1.5 0.4 0.2 1.6 1.7 0.0 0.7 0.3 0.2 0.9 1.0 0.6 0.2 0.3 0.1 0.2 0.0 1.3 0.0 2.3 2.7 1.3 1.3 0.6 0.9 47.8 12.6 0.4 2.8 7.1 0.0 0.0 1.4 9.1 18.1 0.0 0.0 0.1 24.3 0.3 0.3 17.6 83.2 0.6 0.8 0.4 0.5 4.6 2.2 26.0 0.4 0.0 0.0 1.1 0.0 2.7 32.7 26.4 1.2 1.7 0.2 0.0 2.1 8.8 0.0 2.8 0.9 0.0 0.0 0.2 0.1 10.2 0.0 4.6 2.1 2.3 0.0 37.2 0.0 0.0 0.6 0.9 0.0 1.8 10.2 7.0 0.3 3.6 0.1 52.0 2.2 MYC "bHLHe39, c-Myc, MYCC" ENSG00000136997 "MYC proto-oncogene, bHLH transcription factor" P01106 8 127735434-127742951 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 254.6;skin 1: 289.1" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 1013.3;Basal prostatic cells: 1080.5;Basal squamous epithelial cells: 1270.8;Squamous epithelial cells: 768.8;Suprabasal keratinocytes: 1070.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RPMI-8226: 1069.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000084, CAB010307, HPA055893, HPA066556" Approved Enhanced Nucleoplasm NA NA "Cluster 32: T-cells - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 25: RPMI-8226 - Immune response" "Cluster 61: Squamous epithelial cells - Keratinization" Nucleoplasm "CAB000084: , CAB010307: AB_631274, HPA055893: AB_2682960, HPA066556: AB_2685691" "unprognostic (1.45e-2)" "unprognostic (4.00e-3)" "unprognostic (3.94e-3)" "unprognostic (2.41e-3)" "unprognostic (8.14e-2)" "unprognostic (3.36e-3)" "unprognostic (5.80e-2)" "unprognostic (4.94e-3)" "unprognostic (1.59e-1)" "prognostic unfavorable (7.52e-4)" "unprognostic (5.19e-3)" "unprognostic (9.86e-3)" "prognostic unfavorable (5.49e-8)" "unprognostic (7.85e-2)" "unprognostic (4.66e-2)" "unprognostic (2.48e-1)" "prognostic unfavorable (4.96e-5)" 254.6 59.8 2.6 62.3 2.2 53.7 115.8 3.7 3.3 54.4 3.0 57.9 30.6 53.8 3.8 99.5 167.5 83.3 45.5 2.3 6.3 20.0 64.9 47.0 49.4 9.2 5.0 100.0 103.1 7.0 12.3 33.4 6.0 32.7 36.8 0.7 42.2 14.1 50.6 289.1 48.6 54.8 4.5 60.1 70.6 12.5 5.5 47.2 27.0 15.7 39.2 63.2 96.3 4.4 56.8 89.3 9.3 100.9 166.6 209.8 28.4 72.2 31.6 87.5 72.7 137.0 150.2 587.3 86.4 43.0 82.4 122.2 383.8 226.5 67.8 128.9 167.0 370.7 189.5 203.6 150.0 282.0 52.0 138.8 560.4 55.5 490.8 74.8 104.3 217.3 549.8 315.5 49.7 151.9 394.4 616.9 27.4 273.2 204.0 203.7 46.1 1069.6 79.2 61.9 660.7 64.9 32.6 270.7 195.9 17.5 106.4 172.2 120.5 63.4 71.6 49.7 87.2 5.5 8.7 275.9 55.3 286.2 30.8 3.0 39.5 0.7 31.5 36.0 161.5 92.0 114.3 67.4 33.5 71.4 195.2 128.0 4.1 85.5 26.9 1.4 95.6 88.9 2.6 2.2 3.7 3.3 2.3 6.3 9.2 5.0 6.0 4.5 5.5 4.4 218.0 57.7 70.4 0.7 108.0 1013.3 1080.5 278.9 1270.8 0.6 251.3 207.3 10.9 44.3 98.4 12.9 0.0 20.6 20.9 23.0 1.9 78.3 1.0 43.9 224.5 158.0 12.5 189.1 1.6 43.6 61.2 337.9 46.4 72.0 57.0 47.6 141.0 25.8 26.9 0.0 1.1 67.8 97.6 43.7 133.1 3.9 98.8 23.3 168.9 1.0 17.0 1.4 5.2 0.0 0.2 66.5 40.4 67.4 45.7 364.8 4.8 13.3 21.5 0.3 46.0 458.5 349.1 0.6 0.6 768.8 1070.1 5.9 75.0 56.0 117.7 409.4 MYCN "bHLHe37, MYCNOT, N-myc, NMYC" ENSG00000134323 "MYCN proto-oncogene, bHLH transcription factor" P04198 2 15940550-15947007 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding" "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 9.5" "Group enriched" "Detected in some" 4 "Extravillous trophoblasts: 84.2;Granulosa cells: 26.4" "Cancer enriched" "Detected in many" 5 "testis cancer: 45.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 44.1;BEWO: 239.1;HMC-1: 57.3;NTERA-2: 91.3;RH-30: 63.3;SuSa: 40.9" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA057420 Approved Nucleoplasm,Nucleoli NA NA "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 28: BEWO - Transcription regulation" "Cluster 38: Extravillous trophoblasts - Unknown function" Nucleoli Nucleoplasm "HPA057420: AB_2683434" "unprognostic (8.04e-2)" "unprognostic (1.96e-1)" "unprognostic (1.29e-1)" "unprognostic (2.07e-2)" "unprognostic (4.11e-1)" "unprognostic (2.46e-2)" "unprognostic (1.23e-2)" "unprognostic (3.03e-2)" "unprognostic (1.81e-1)" "unprognostic (3.35e-3)" "unprognostic (3.09e-2)" "unprognostic (2.09e-1)" "unprognostic (1.12e-3)" "unprognostic (8.89e-2)" "unprognostic (2.47e-1)" "unprognostic (4.90e-2)" "unprognostic (1.23e-1)" 0.4 0.8 3.5 0.6 3.5 0.9 0.4 3.1 3.9 1.5 0.8 0.6 1.6 0.9 0.1 0.7 0.5 0.3 1.2 3.4 3.0 3.3 0.8 0.7 1.6 4.4 3.9 5.1 0.2 0.1 0.3 9.5 3.7 0.1 0.5 1.0 4.7 0.2 0.4 1.4 0.9 0.3 3.3 0.3 4.6 3.6 3.5 2.9 2.9 0.7 1.2 0.5 0.4 5.9 0.0 0.0 44.1 0.0 0.0 0.0 239.1 0.0 0.0 0.0 0.0 3.5 0.0 0.0 4.2 0.0 0.0 0.1 1.9 0.0 0.0 0.0 0.2 16.8 0.0 0.0 0.0 0.0 57.3 0.0 0.0 0.0 0.0 0.0 0.2 0.7 0.0 0.1 0.0 0.8 0.4 0.2 91.3 2.1 0.0 0.0 63.3 12.8 0.0 3.1 1.0 16.0 0.0 0.1 0.0 40.9 0.1 0.0 0.0 0.0 1.2 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.5 3.5 3.1 3.9 3.4 3.0 4.4 3.9 3.7 3.3 3.5 5.9 0.8 0.0 0.0 0.7 0.0 0.5 0.1 0.0 0.0 2.6 0.1 0.9 0.7 0.0 0.0 0.0 0.0 5.6 0.0 0.2 0.0 0.0 1.2 0.5 0.1 2.7 0.0 4.2 2.0 0.0 84.2 1.0 2.6 0.8 0.0 26.4 0.0 0.6 2.4 0.0 4.2 0.9 0.0 0.0 0.0 0.2 0.0 0.3 0.0 1.0 0.1 1.0 0.0 10.1 7.5 0.3 1.1 0.4 0.0 0.0 0.4 3.2 0.0 0.2 0.0 4.2 0.7 1.3 3.7 0.3 0.0 11.5 0.0 9.4 0.3 0.0 MYD88 ENSG00000172936 "MYD88 innate immune signal transduction adaptor" Q99836 3 38138478-38143022 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Immunity, Inflammatory response, Innate immunity" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Kupffer cells: 75.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SK-BR-3: 172.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB009104 Approved Supported Vesicles,Mitochondria,Cytosol NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 64: Macrophages - Immune response" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Cytosol "Vesicles, Mitochondria" "CAB009104: AB_2146724" "prognostic favorable (8.45e-4)" "unprognostic (1.19e-1)" "unprognostic (4.31e-2)" "unprognostic (2.51e-2)" "unprognostic (4.77e-2)" "unprognostic (4.38e-3)" "unprognostic (4.37e-2)" "unprognostic (3.63e-1)" "unprognostic (1.67e-1)" "unprognostic (7.28e-2)" "unprognostic (1.01e-2)" "unprognostic (7.30e-2)" "unprognostic (2.11e-2)" "unprognostic (4.41e-1)" "unprognostic (4.17e-2)" "unprognostic (1.65e-1)" "unprognostic (2.08e-2)" 20.1 14.2 6.9 43.5 7.4 51.8 15.0 7.2 7.5 15.2 8.0 30.3 32.2 12.1 18.6 36.6 14.4 23.5 9.4 6.7 7.7 13.7 61.1 42.6 35.2 9.5 7.5 11.4 11.6 11.6 9.2 22.6 8.0 14.3 31.7 2.1 18.0 12.0 3.2 17.7 32.2 24.5 8.6 40.7 27.6 7.7 9.2 38.3 9.4 8.8 41.6 47.4 20.3 8.5 25.1 34.2 5.9 33.2 25.0 32.0 10.8 23.6 39.0 68.1 72.9 22.7 30.9 52.8 13.8 44.7 15.8 30.9 43.2 24.2 22.1 39.5 8.7 28.5 16.6 36.6 21.4 36.2 72.0 38.4 26.6 39.2 15.3 13.2 39.9 40.3 13.3 22.3 36.8 25.7 61.3 12.2 22.1 52.8 35.7 24.8 7.0 23.1 37.6 58.9 3.0 12.0 33.4 172.1 22.3 4.8 25.8 40.8 35.5 13.8 7.9 60.6 24.0 28.9 32.9 38.5 25.0 63.0 28.9 288.5 236.9 296.9 67.2 333.6 58.1 43.7 60.6 69.3 203.6 35.2 42.1 59.5 284.7 54.6 436.1 99.9 87.4 257.3 6.9 7.4 7.2 7.5 6.7 7.7 9.5 7.5 8.0 8.6 9.2 8.5 13.4 6.4 15.2 2.0 19.5 14.4 13.5 12.7 14.2 1.0 11.3 10.8 1.6 5.7 16.4 5.5 0.0 14.6 35.3 40.8 7.9 24.5 1.4 10.9 30.2 15.9 9.6 9.7 0.2 27.3 24.4 10.8 23.9 18.6 24.1 10.0 10.4 33.2 32.2 0.0 0.4 14.9 10.2 75.4 40.5 0.9 13.7 61.5 3.6 1.9 58.1 4.1 28.8 2.5 0.3 64.0 34.8 10.5 12.9 16.0 28.0 12.2 12.1 0.1 13.1 4.3 7.2 8.6 0.6 15.1 17.2 12.0 19.6 10.2 15.9 49.4 NAV3 "KIAA0938, POMFIL1" ENSG00000067798 "Neuron navigator 3" Q8IVL0 12 77324641-78213010 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 17.3;ovary: 18.3" "Group enriched" "Detected in many" 6 "Astrocytes: 882.1;Excitatory neurons: 1473.6;Inhibitory neurons: 753.8;Microglial cells: 534.0;Oligodendrocyte precursor cells: 786.1" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in many" 8 "amygdala: 9.7;basal ganglia: 15.0;cerebral cortex: 17.3;hippocampal formation: 13.6;white matter: 10.3" "Immune cell enhanced" "Detected in single" "neutrophil: 1.0" "Lineage enriched" "Detected in single" 9 "granulocytes: 1.0" "Cell line enhanced" "Detected in many" "hTEC/SVTERT24-B: 47.0;THP-1: 41.8;U-138 MG: 30.8;WM-115: 38.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA032111, HPA061392" Approved Approved "Nuclear membrane,Cytosol" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nuclear membrane" Cytosol "HPA032111: AB_10603881, HPA061392: " "unprognostic (3.51e-1)" "unprognostic (6.72e-2)" "unprognostic (1.09e-2)" "unprognostic (1.79e-1)" "unprognostic (8.98e-2)" "unprognostic (2.14e-1)" "unprognostic (2.78e-1)" "unprognostic (3.25e-2)" "unprognostic (3.03e-2)" "unprognostic (2.06e-2)" "unprognostic (2.99e-1)" "unprognostic (1.90e-1)" "unprognostic (5.68e-7)" "unprognostic (6.86e-3)" "unprognostic (1.23e-1)" "unprognostic (1.58e-2)" "unprognostic (2.29e-3)" 3.8 4.8 9.7 1.0 15.0 0.5 4.0 0.9 17.3 1.2 0.0 1.7 0.3 2.0 2.9 1.9 2.2 5.1 1.9 13.6 0.0 0.4 1.0 3.3 0.6 0.7 0.4 18.3 0.5 0.4 3.1 2.2 0.0 2.1 0.8 5.2 0.9 2.5 1.3 2.6 0.6 2.5 1.4 8.0 0.8 2.8 1.6 1.9 1.2 3.4 0.4 3.3 1.7 10.3 3.5 8.7 0.6 0.2 8.5 18.1 0.3 26.5 20.9 10.7 5.3 1.7 0.6 0.2 1.9 22.0 7.2 2.5 7.8 4.0 19.3 0.1 0.2 0.2 3.9 0.2 6.7 0.1 0.2 6.2 0.2 47.0 11.1 9.3 16.4 0.1 0.0 0.1 26.2 0.5 0.2 12.0 2.7 0.3 2.1 1.0 2.1 0.0 1.7 0.1 0.6 0.0 1.6 0.3 3.5 0.8 0.1 41.8 14.1 30.8 8.1 12.0 18.2 1.2 0.0 0.7 8.8 0.5 38.7 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 9.7 15.0 0.9 17.3 13.6 0.0 0.7 0.4 0.0 1.4 1.6 10.3 11.1 19.2 10.0 882.1 0.0 3.6 8.4 0.2 0.0 5.0 3.8 3.8 3.4 0.0 7.5 0.0 0.0 0.1 0.0 0.2 0.0 4.2 10.4 4.2 8.2 5.6 16.4 0.0 1473.6 1.6 0.1 18.7 0.5 10.3 11.4 0.8 3.9 0.0 7.3 50.5 753.8 0.0 0.0 0.0 3.7 4.7 23.9 1.4 12.4 534.0 0.1 18.3 0.0 786.1 144.1 19.2 0.0 7.5 1.2 18.0 0.0 0.3 8.7 2.0 0.0 28.8 5.3 0.3 0.8 0.2 1.4 0.3 1.3 73.7 0.0 2.9 NCOA4 "ARA70, DKFZp762E1112, ELE1, PTC3, RFG" ENSG00000266412 "Nuclear receptor coactivator 4" Q13772 10 46005088-46030623 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Transcription, Transcription regulation" Activator "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Erythroid cells: 476.2;Macrophages: 316.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 4 "dendritic cells: 251.9;granulocytes: 839.6;monocytes: 363.6" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA051260, HPA065208" Uncertain Approved "Nucleoli,Golgi apparatus,Cytosol" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 51: Myeloid cells - Hemostasis" Nucleoli "Golgi apparatus, Cytosol" "HPA051260: AB_2681412, HPA065208: AB_2685432" "unprognostic (4.23e-2)" "unprognostic (1.50e-1)" "unprognostic (2.44e-2)" "unprognostic (1.82e-1)" "prognostic favorable (3.26e-4)" "unprognostic (1.34e-1)" "unprognostic (1.80e-1)" "unprognostic (9.34e-2)" "unprognostic (4.67e-2)" "unprognostic (5.22e-2)" "unprognostic (9.16e-2)" "unprognostic (2.04e-2)" "prognostic favorable (8.04e-6)" "unprognostic (1.35e-1)" "unprognostic (4.71e-3)" "unprognostic (1.14e-1)" "unprognostic (2.78e-1)" 117.1 67.8 45.6 91.5 52.5 189.5 96.9 56.1 50.9 85.1 50.7 110.3 249.7 70.2 74.6 110.3 62.6 87.8 156.8 40.6 55.8 159.7 372.9 108.3 102.6 52.4 53.5 65.5 64.6 97.9 25.2 131.3 53.6 132.2 115.7 33.7 79.2 78.7 163.5 71.1 155.9 98.3 52.6 148.1 90.3 43.6 51.6 124.4 87.0 193.6 150.3 104.6 46.8 60.0 142.7 58.5 68.0 70.4 176.9 159.4 170.3 128.3 204.8 122.1 119.6 91.0 102.3 161.2 149.2 211.2 69.1 141.8 72.6 142.3 137.1 114.4 74.1 108.4 74.3 263.5 124.0 279.9 229.7 156.1 139.2 104.2 175.7 131.6 185.5 79.5 119.7 93.5 171.9 64.0 136.1 104.3 41.4 110.2 34.8 79.5 99.3 96.7 148.9 119.4 68.2 46.1 128.9 146.2 131.5 133.5 105.7 135.3 171.6 75.8 89.9 81.3 87.5 69.3 79.1 156.9 94.6 231.2 41.2 692.1 363.6 611.8 78.9 223.6 86.2 57.6 73.3 74.9 251.9 53.8 78.2 66.4 839.6 119.0 275.3 77.4 92.8 559.4 45.6 52.5 56.1 50.9 40.6 55.8 52.4 53.5 53.6 52.6 51.6 60.0 44.5 51.3 95.2 13.4 44.6 49.5 39.3 126.2 50.7 14.3 49.6 38.5 161.3 45.8 96.2 44.1 29.2 104.7 58.2 108.8 80.3 45.3 105.4 45.1 37.7 52.9 26.9 476.2 17.4 51.8 107.2 45.3 42.3 56.9 195.2 28.2 55.3 166.7 181.4 20.2 20.5 45.4 59.0 254.5 74.2 72.4 37.3 316.1 51.6 16.9 158.4 38.2 44.3 18.6 22.9 47.8 63.9 47.4 37.6 62.0 162.5 128.8 59.7 13.0 13.1 36.7 46.7 24.5 16.5 71.9 56.7 158.2 41.3 60.7 71.3 52.0 NF1 ENSG00000196712 "Neurofibromin 1" P21359 17 31094927-31382116 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "GTPase activation" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 254.0;Excitatory neurons: 325.3;Inhibitory neurons: 412.5;Oligodendrocyte precursor cells: 428.2;Oligodendrocytes: 317.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045502 Uncertain Approved Mitochondria No No "Cluster 20: T-cells - T-cell receptor" "Cluster 21: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Mitochondria "HPA045502: AB_2679352" "unprognostic (6.69e-2)" "unprognostic (8.73e-2)" "unprognostic (8.26e-2)" "unprognostic (1.76e-2)" "unprognostic (2.06e-2)" "unprognostic (2.79e-2)" "unprognostic (1.38e-1)" "unprognostic (1.07e-1)" "unprognostic (1.11e-1)" "unprognostic (1.30e-2)" "unprognostic (3.14e-2)" "unprognostic (3.88e-2)" "unprognostic (1.00e-2)" "unprognostic (2.19e-1)" "unprognostic (1.53e-1)" "unprognostic (1.40e-1)" "unprognostic (3.70e-1)" 7.4 8.4 8.9 7.1 10.7 3.4 11.5 13.2 12.2 10.0 1.6 8.5 6.8 10.2 10.0 6.1 9.0 8.0 11.3 9.7 11.7 12.0 9.4 7.3 7.7 11.7 9.2 13.5 10.4 15.9 7.8 12.4 9.1 9.5 8.8 20.9 9.1 9.5 8.1 7.4 7.5 8.7 8.2 7.1 8.2 10.0 11.8 13.5 19.5 10.6 7.8 10.4 6.8 14.4 15.8 20.3 24.2 13.1 20.1 25.8 12.2 13.4 24.1 19.5 21.8 18.4 10.5 15.2 3.8 25.1 22.9 26.8 22.2 18.7 32.6 7.5 14.1 13.4 18.8 9.5 14.2 24.4 10.6 20.7 11.8 20.8 25.1 21.8 9.5 15.7 19.8 14.8 18.8 12.4 20.4 8.8 7.1 9.7 6.8 15.8 36.8 12.3 14.7 22.5 10.0 14.9 25.4 8.3 13.8 16.8 25.0 15.3 14.1 15.3 21.5 18.8 5.1 13.2 6.9 16.3 12.6 10.0 16.2 4.4 0.3 0.6 1.5 0.1 1.0 1.4 2.8 2.5 0.4 1.2 2.0 2.0 0.7 0.7 0.3 0.4 5.9 0.6 8.9 10.7 13.2 12.2 9.7 11.7 11.7 9.2 9.1 8.2 11.8 14.4 30.9 32.1 31.1 254.0 18.3 38.6 48.1 38.9 31.9 62.7 33.7 24.9 43.9 41.5 29.8 40.5 137.6 57.5 23.8 37.8 23.5 27.1 210.4 27.4 39.4 35.8 19.8 9.7 325.3 22.5 26.6 39.1 39.3 45.8 10.8 44.0 33.2 35.7 22.5 70.7 412.5 24.3 38.7 27.6 34.1 94.6 37.3 28.2 21.4 215.5 20.9 47.5 21.6 428.2 317.4 33.3 43.0 50.4 30.8 54.2 32.1 28.6 36.9 62.8 46.0 51.9 43.3 30.5 28.7 19.8 34.0 49.3 19.8 36.1 27.4 64.5 NF2 "ACN, BANF, merlin, SCH" ENSG00000186575 "Neurofibromin 2" P35240 22 29603556-29698598 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cancer-related genes, Deafness, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 77.1;Late spermatids: 121.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003097, CAB005385" Supported Enhanced "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 31: Spermatids - Spermatogenesis" "Plasma membrane" "Nucleoplasm, Cytosol" "CAB005385: AB_2298548, HPA003097: AB_1079473" "unprognostic (3.27e-1)" "unprognostic (1.34e-2)" "unprognostic (1.34e-1)" "unprognostic (1.76e-2)" "unprognostic (3.14e-1)" "unprognostic (1.62e-1)" "unprognostic (5.76e-3)" "unprognostic (1.61e-1)" "unprognostic (3.67e-2)" "unprognostic (2.16e-2)" "unprognostic (2.01e-3)" "unprognostic (4.66e-1)" "prognostic favorable (2.89e-5)" "unprognostic (7.73e-3)" "unprognostic (1.31e-1)" "unprognostic (2.24e-1)" "unprognostic (9.62e-2)" 8.8 13.6 19.7 8.4 17.2 8.0 7.6 13.6 28.7 8.9 10.7 10.8 6.2 11.1 6.2 13.4 8.6 5.3 21.4 27.3 13.9 17.2 10.5 9.3 6.4 14.4 18.1 8.5 12.7 27.4 9.5 4.6 14.3 9.9 5.4 7.3 8.5 6.7 22.8 10.2 8.8 8.0 14.3 9.9 10.0 20.9 17.6 9.3 11.1 19.1 7.1 9.3 7.7 16.6 75.8 36.7 12.2 74.3 21.5 22.0 7.7 57.3 37.9 74.1 53.7 32.7 18.4 21.1 50.4 69.9 48.9 27.1 25.1 37.8 52.0 31.9 12.5 26.8 24.4 26.4 22.4 35.1 28.6 20.1 16.4 53.3 51.0 21.8 47.7 13.7 12.0 18.7 64.5 35.1 21.4 16.6 8.3 16.9 20.4 24.2 56.8 18.8 68.5 37.3 17.0 11.6 36.0 24.5 14.0 9.4 14.9 15.4 92.7 101.1 109.6 44.8 112.5 30.0 26.7 25.5 27.0 14.5 68.5 10.0 10.0 4.2 15.5 14.7 13.1 8.3 11.5 10.4 15.1 8.6 9.7 9.2 2.3 13.2 21.0 10.2 10.7 12.2 19.7 17.2 13.6 28.7 27.3 13.9 14.4 18.1 14.3 14.3 17.6 16.6 8.1 6.4 20.1 14.7 9.4 14.1 11.6 9.8 8.6 16.3 14.5 9.0 23.1 18.6 10.0 14.7 10.4 11.7 12.7 9.0 21.5 40.0 77.1 14.5 17.7 13.2 13.1 13.9 27.5 24.9 6.7 12.5 7.7 15.2 22.9 12.2 11.7 14.4 13.5 30.3 27.1 7.9 6.1 14.7 7.5 121.4 7.2 10.2 8.8 18.7 8.6 19.1 14.4 17.6 16.7 40.1 14.5 12.4 14.7 13.6 10.5 30.1 8.6 9.6 6.6 13.7 15.6 29.5 8.1 15.5 14.3 3.8 12.9 17.4 11.2 9.5 NFE2L2 NRF2 ENSG00000116044 "Nuclear factor, erythroid 2 like 2" Q16236 2 177227595-177392697 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Host-virus interaction, Transcription, Transcription regulation" "Activator, DNA-binding" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002990, CAB020317, HPA043438" Supported Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 37: Intestine - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 41: Macrophages - Immune response" "Nucleoplasm, Plasma membrane" Cytosol "CAB020317: , HPA002990: AB_1079476, HPA043438: AB_2678482" "unprognostic (2.11e-1)" "unprognostic (3.12e-2)" "unprognostic (5.22e-2)" "unprognostic (1.41e-1)" "unprognostic (5.95e-2)" "unprognostic (3.90e-1)" "unprognostic (5.27e-2)" "unprognostic (9.58e-2)" "unprognostic (3.48e-2)" "unprognostic (9.86e-2)" "unprognostic (4.86e-2)" "unprognostic (1.83e-1)" "prognostic favorable (2.26e-4)" "unprognostic (1.97e-2)" "unprognostic (1.61e-1)" "unprognostic (1.26e-1)" "unprognostic (9.77e-3)" 87.0 73.6 64.8 65.4 83.9 58.9 78.3 74.9 86.7 83.2 78.7 83.4 100.1 92.6 97.2 257.0 88.5 97.7 77.6 66.5 71.6 143.5 176.6 88.5 50.4 82.0 77.5 137.3 47.3 60.4 58.4 80.4 84.5 72.7 85.8 68.2 79.7 90.5 64.4 162.3 82.9 91.8 70.4 69.0 176.9 65.2 75.7 68.2 130.4 65.9 93.8 160.7 108.7 91.8 53.1 57.3 52.2 56.4 181.4 190.2 61.7 91.8 124.9 81.4 90.5 75.9 97.9 52.8 93.8 102.8 148.4 96.9 65.1 136.7 111.5 40.8 41.1 65.9 95.9 156.3 231.2 39.3 60.6 134.0 314.5 115.5 169.3 184.4 80.9 39.7 72.7 91.4 111.8 49.8 42.3 101.9 58.8 277.2 58.9 34.0 46.5 54.6 120.9 182.1 69.0 45.0 202.9 64.8 216.6 147.8 49.1 105.0 119.9 80.4 54.5 89.5 54.7 70.1 44.7 43.1 81.6 43.3 159.4 130.6 89.3 55.4 55.2 84.3 62.9 61.8 64.0 57.0 100.4 51.9 101.2 66.8 103.2 68.1 83.0 38.8 66.6 66.0 64.8 83.9 74.9 86.7 66.5 71.6 82.0 77.5 84.5 70.4 75.7 91.8 193.3 157.0 93.5 66.3 143.3 295.8 241.8 448.4 306.7 61.3 90.0 113.7 67.9 117.2 247.0 154.5 16.7 113.2 249.1 120.7 393.2 154.5 81.4 238.1 126.9 139.6 75.6 58.0 25.3 170.8 34.5 206.6 170.7 279.9 212.7 141.5 120.0 93.2 88.1 57.2 26.6 73.5 321.4 111.6 569.9 39.0 287.7 266.0 96.0 88.1 170.6 191.4 55.6 63.8 113.0 128.3 91.8 214.0 118.8 150.5 94.9 85.0 205.9 48.4 39.5 211.8 152.4 66.1 32.1 617.9 315.4 186.2 150.6 153.5 119.6 225.2 NFKBIA "IkappaBalpha, IKBA, MAD-3, NFKBI" ENSG00000100906 "NFKB inhibitor alpha" P25963 14 35401513-35404749 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Host-virus interaction" "Cancer-related genes, Disease variant, Ectodermal dysplasia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 1114.7" "Cell type enhanced" "Detected in all" "Basal keratinocytes: 4056.6;Langerhans cells: 4828.7;Suprabasal keratinocytes: 3420.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RT4: 391.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003815, HPA029207" Approved Enhanced Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 15: RT4 - Unknown function" "Cluster 41: Macrophages - Immune response" Cytosol "CAB003815: AB_344886, HPA029207: AB_10603122" "prognostic favorable (1.33e-5)" "unprognostic (3.39e-1)" "unprognostic (7.29e-2)" "unprognostic (7.24e-2)" "unprognostic (8.88e-2)" "unprognostic (1.62e-1)" "unprognostic (3.51e-1)" "unprognostic (2.46e-1)" "unprognostic (2.39e-1)" "unprognostic (2.46e-1)" "unprognostic (2.46e-1)" "unprognostic (7.19e-2)" "unprognostic (2.32e-2)" "unprognostic (3.69e-1)" "unprognostic (4.44e-2)" "unprognostic (9.74e-2)" "unprognostic (3.80e-2)" 281.0 171.3 75.6 150.7 78.0 1114.7 171.4 75.4 92.5 123.8 78.3 121.0 61.2 95.5 29.6 151.8 141.2 130.4 145.5 71.4 75.9 104.5 208.1 366.0 122.6 90.1 76.2 255.7 101.9 68.8 92.4 92.7 81.6 112.6 80.9 18.7 118.3 110.0 139.7 260.5 148.5 92.7 77.0 226.2 130.7 31.7 84.9 123.2 111.9 138.3 181.4 366.2 166.8 79.8 62.5 54.1 20.1 18.2 114.7 75.9 71.1 25.2 240.7 53.3 47.3 16.9 36.5 37.5 66.1 40.2 125.2 79.5 38.3 104.9 76.1 229.2 14.9 18.6 39.9 101.4 68.6 29.9 15.0 83.1 103.5 36.4 92.2 35.5 48.6 18.4 15.9 58.4 38.6 73.0 39.2 71.0 18.6 60.0 33.1 87.8 23.1 31.6 92.8 391.7 17.9 31.2 67.2 115.9 29.7 41.0 66.1 62.2 91.7 72.8 26.5 21.3 41.0 70.9 77.7 64.5 60.8 22.0 15.3 322.0 444.9 301.4 175.3 267.2 264.0 258.4 207.1 182.5 428.9 329.7 178.1 153.0 942.9 285.9 183.7 233.0 154.9 506.4 75.6 78.0 75.4 92.5 71.4 75.9 90.1 76.2 81.6 77.0 84.9 79.8 802.9 535.2 914.0 14.4 505.6 4056.6 1862.8 2061.4 1729.6 27.0 430.7 414.0 188.6 367.4 719.2 62.5 12.5 196.4 762.2 447.8 195.6 875.0 4.3 703.8 935.6 1079.8 203.5 87.8 7.1 394.8 174.9 1145.1 333.8 1440.1 906.1 68.2 313.4 147.2 791.2 48.8 5.1 453.0 634.7 491.4 4828.7 14.7 153.1 1609.0 1085.1 39.4 428.1 95.2 97.9 6.6 8.6 383.5 511.5 116.2 1039.4 1412.0 1051.6 115.9 298.2 37.4 203.8 956.9 847.2 3.3 26.4 1544.6 3420.6 660.0 838.4 91.8 346.0 1004.6 NFKBIE IKBE ENSG00000146232 "NFKB inhibitor epsilon" O00221 6 44258166-44265788 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Langerhans cells: 151.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002692, HPA005941, CAB010272" Supported Supported "Nucleoplasm,Nucleoli fibrillar center,Cytosol" NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 2: Immune cells - Immune response" "Cluster 24: NB-4 - Immune response" "Cluster 41: Macrophages - Immune response" "Nucleoli fibrillar center" "Nucleoplasm, Cytosol" "CAB010272: AB_2235977, HPA002692: AB_1079479, HPA005941: AB_1079478" "prognostic favorable (1.72e-5)" "unprognostic (1.43e-1)" "unprognostic (1.39e-2)" "unprognostic (2.37e-2)" "unprognostic (6.32e-3)" "unprognostic (1.28e-1)" "prognostic unfavorable (3.50e-4)" "unprognostic (4.88e-2)" "unprognostic (1.09e-1)" "unprognostic (3.43e-2)" "unprognostic (3.36e-1)" "unprognostic (2.60e-1)" "prognostic unfavorable (1.37e-6)" "unprognostic (2.61e-2)" "unprognostic (8.83e-2)" "unprognostic (1.37e-2)" "prognostic favorable (8.07e-4)" 6.8 5.8 10.9 19.1 10.8 31.5 5.9 12.1 17.6 4.1 10.7 7.2 7.4 3.7 4.7 5.9 3.3 8.3 5.3 11.3 10.6 16.1 10.5 13.6 19.9 11.5 11.4 2.7 8.3 5.3 4.5 5.5 11.2 8.3 5.9 3.7 7.4 3.3 3.5 9.9 12.1 3.6 11.7 35.0 7.0 10.7 11.8 9.9 5.3 3.9 25.1 16.3 5.0 12.3 28.4 7.9 9.5 15.1 3.7 2.8 5.3 4.9 23.8 14.9 15.4 15.0 12.9 15.7 17.0 5.1 39.7 6.2 10.3 15.4 16.6 26.1 6.0 7.9 3.0 17.0 11.4 26.1 23.0 7.1 6.7 13.8 8.8 12.5 10.7 7.2 7.7 39.2 3.9 14.4 5.2 52.7 5.0 44.1 4.0 9.9 8.5 14.0 34.7 30.3 6.1 7.8 3.4 12.5 20.9 8.0 8.6 29.9 18.1 8.4 9.8 5.3 15.4 25.0 11.4 28.7 7.4 28.4 16.1 8.8 7.5 4.0 1.6 9.4 3.2 8.6 2.2 1.5 6.6 6.5 1.0 1.6 3.0 0.8 11.1 8.1 3.1 1.7 10.9 10.8 12.1 17.6 11.3 10.6 11.5 11.4 11.2 11.7 11.8 12.3 7.5 0.0 9.7 1.0 26.0 38.2 28.7 11.6 14.8 3.4 15.3 9.9 5.4 22.8 9.2 3.7 2.1 5.2 12.5 12.2 17.6 49.5 17.3 10.0 6.2 15.9 14.9 1.7 1.1 21.0 8.0 17.3 10.7 12.8 32.5 2.5 6.1 2.0 57.2 3.3 2.0 11.9 6.1 22.6 151.2 34.1 1.8 48.6 48.0 3.7 55.2 3.3 1.0 0.5 0.9 58.9 33.3 2.6 18.7 32.6 14.3 14.4 6.1 4.1 6.6 11.8 11.0 25.9 12.3 11.6 39.2 5.3 13.8 7.0 8.5 34.7 NKX3-1 "BAPX2, NKX3.1, NKX3A" ENSG00000167034 "NK3 homeobox 1" Q99801 8 23678697-23682938 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "DNA-binding, Repressor" "Cancer-related genes, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "prostate: 303.3" "Group enriched" "Detected in many" 6 "Basal prostatic cells: 51.0;Prostatic glandular cells: 124.8" "Cancer enriched" "Detected in many" 65 "prostate cancer: 392.7" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "eosinophil: 54.0;neutrophil: 51.6" "Lineage enriched" "Detected in many" 21 "granulocytes: 54.0" "Cell line enhanced" "Detected in many" "GAMG: 25.7;SiHa: 26.1;U-138 MG: 25.8;U-251 MG: 23.0" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" "HPA025693, HPA078571" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 51: Non-specific - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 35: Glandular cells - Unknown function" Nucleoplasm Cytosol "HPA025693: AB_1854522, HPA078571: AB_2732384" "unprognostic (1.47e-2)" "unprognostic (4.03e-2)" "unprognostic (2.67e-1)" "unprognostic (5.87e-2)" "unprognostic (2.56e-6)" "unprognostic (6.90e-3)" "unprognostic (1.13e-1)" "unprognostic (4.11e-3)" "unprognostic (9.42e-2)" "unprognostic (1.41e-1)" "unprognostic (3.00e-2)" "unprognostic (1.87e-1)" "unprognostic (4.37e-2)" "unprognostic (4.60e-2)" "unprognostic (3.88e-2)" "unprognostic (3.09e-2)" "unprognostic (1.69e-1)" 1.7 3.9 1.0 1.5 1.2 2.2 2.1 1.4 1.4 1.1 0.9 1.4 1.4 1.5 1.3 3.7 1.8 1.1 2.6 1.2 1.6 1.4 4.1 1.4 1.2 1.8 1.5 2.8 1.8 1.0 0.9 0.8 1.6 303.3 0.5 1.7 62.0 1.8 3.2 0.4 1.0 1.9 1.7 0.8 1.4 24.0 1.5 0.5 0.7 3.9 1.6 2.9 1.9 1.4 4.9 3.7 0.0 8.7 3.1 0.7 7.1 6.7 4.2 13.8 16.2 2.1 5.5 0.0 1.0 5.0 25.7 1.2 3.5 7.6 10.9 0.0 1.8 3.4 2.6 5.5 6.0 0.0 1.2 1.2 2.0 14.0 0.8 8.5 0.7 20.1 0.2 0.0 5.5 1.6 11.8 1.0 2.0 0.0 2.6 0.0 5.5 0.5 0.8 5.7 1.6 0.4 26.1 4.8 0.4 9.9 3.5 0.5 0.9 25.8 9.1 2.0 23.0 0.0 0.0 0.0 12.5 2.6 3.2 10.2 0.0 54.0 1.0 0.1 0.2 2.2 0.4 1.0 0.1 1.8 1.4 2.5 51.6 0.6 0.1 0.0 0.0 0.3 1.0 1.2 1.4 1.4 1.2 1.6 1.8 1.5 1.6 1.7 1.5 1.4 6.0 3.2 5.3 0.0 4.1 5.6 51.0 4.1 4.6 3.7 13.5 6.5 9.8 1.5 4.7 0.0 8.4 0.3 0.3 1.0 0.0 2.7 2.7 1.3 2.0 6.8 6.6 0.0 0.4 7.0 1.4 9.1 5.1 2.2 0.0 0.8 4.6 4.9 0.3 3.3 0.4 1.2 2.0 0.3 9.4 6.1 2.1 2.5 1.8 0.0 0.6 4.9 0.0 0.5 0.1 5.2 0.1 6.4 1.0 124.8 0.4 0.7 1.4 4.5 0.0 11.4 5.1 1.8 2.1 2.5 2.0 0.3 2.5 0.8 1.1 12.2 NOS2 "HEP-NOS, iNOS, NOS, NOS2A" ENSG00000007171 "Nitric oxide synthase 2" P35228 17 27756766-27800529 "Cancer-related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Calmodulin-binding, Oxidoreductase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "intestine: 21.1;lymphoid tissue: 14.4" "Cell type enhanced" "Detected in some" "Distal enterocytes: 40.3;Extravillous trophoblasts: 27.7;Granulosa cells: 57.3;Proximal enterocytes: 10.7;Undifferentiated cells: 10.2" "Cancer enhanced" "Detected in many" "colorectal cancer: 16.0" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 9 "CACO-2: 16.5;SCLC-21H: 13.0" "Not detected" "Not detected" "Low region specificity" "Detected in many" CAB002014 Enhanced NA NA "Cluster 56: Intestine - Transmembrane transport" "Cluster 39: CACO-2 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB002014: " "unprognostic (1.95e-3)" "unprognostic (3.08e-3)" "unprognostic (4.75e-3)" "unprognostic (4.42e-3)" "unprognostic (3.49e-1)" "unprognostic (2.13e-2)" "unprognostic (5.61e-2)" "unprognostic (5.09e-2)" "unprognostic (9.91e-3)" "unprognostic (1.93e-1)" "unprognostic (2.39e-2)" "unprognostic (1.34e-1)" "unprognostic (6.04e-2)" "unprognostic (8.02e-2)" "unprognostic (3.68e-1)" "unprognostic (8.69e-2)" "unprognostic (4.03e-2)" 0.9 0.5 0.2 14.4 0.5 0.0 0.3 0.1 2.1 0.3 0.0 6.8 12.1 0.2 0.0 0.7 0.4 0.4 0.4 0.7 0.2 1.6 0.1 1.8 0.8 0.3 0.1 0.6 0.3 0.1 1.3 0.6 0.5 0.6 8.9 0.2 0.1 0.2 0.8 0.2 21.1 1.8 0.1 0.1 0.1 0.3 1.0 0.1 0.4 0.7 0.1 3.6 0.2 0.9 0.0 0.1 0.1 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 16.5 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 13.0 0.9 0.0 0.1 0.1 0.7 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.5 0.1 2.1 0.7 0.2 0.3 0.1 0.5 0.1 1.0 0.9 1.2 0.0 0.0 1.3 0.6 0.0 0.2 3.6 0.0 0.5 0.0 0.3 0.2 0.0 0.7 0.0 0.0 0.2 0.0 40.3 0.0 0.0 0.2 0.0 0.0 0.7 2.4 0.0 4.1 0.0 27.7 0.2 0.0 0.1 0.0 57.3 0.0 0.0 0.7 0.0 2.2 3.8 2.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 4.9 0.4 0.0 1.4 10.7 0.1 0.5 0.1 0.0 0.3 1.2 0.0 1.5 0.0 0.0 0.5 0.3 0.1 10.2 1.0 NOTCH1 TAN1 ENSG00000148400 "Notch receptor 1" P46531 9 136494433-136546048 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Angiogenesis, Differentiation, Notch signaling pathway, Transcription, Transcription regulation" "Activator, Developmental protein, Receptor" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Adipocytes: 56.2;Astrocytes: 67.3;Hepatic stellate cells: 68.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "neutrophil: 2.3" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "HaCaT: 47.0;HDLM-2: 32.3;HMC-1: 39.7;MOLT-4: 72.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008112, CAB022466, HPA067168" Supported Approved Nucleoplasm NA NA 29000000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 64: Macrophages - Immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Nucleoplasm "CAB008112: AB_2153490, CAB022466: , HPA067168: AB_2685795" "unprognostic (1.77e-1)" "unprognostic (2.65e-2)" "unprognostic (2.16e-1)" "unprognostic (8.38e-3)" "unprognostic (3.04e-1)" "unprognostic (1.13e-1)" "unprognostic (7.56e-2)" "unprognostic (1.02e-1)" "unprognostic (5.74e-3)" "unprognostic (5.50e-3)" "unprognostic (8.78e-2)" "unprognostic (8.50e-2)" "prognostic unfavorable (5.45e-4)" "unprognostic (2.14e-2)" "unprognostic (1.92e-1)" "unprognostic (5.65e-2)" "unprognostic (8.84e-2)" 18.2 4.2 10.4 4.9 16.1 4.3 15.0 12.1 9.3 14.3 0.0 19.8 4.3 12.7 0.2 16.3 11.9 0.9 14.9 8.6 5.5 11.8 9.2 22.2 3.0 13.5 12.3 5.1 14.0 0.7 6.3 2.6 9.8 15.4 0.6 0.6 10.7 3.1 5.0 24.2 14.2 1.3 9.7 24.8 10.0 2.5 13.9 4.0 11.2 1.2 0.9 14.2 16.5 14.0 8.8 10.6 4.0 2.6 0.0 0.4 17.7 3.3 0.4 1.4 0.4 1.8 0.9 13.3 10.3 1.3 1.6 47.0 1.0 8.6 0.1 32.3 2.0 5.5 6.1 0.6 2.1 6.9 39.7 0.3 16.7 1.4 1.9 0.7 9.0 3.7 3.6 1.1 0.0 9.0 72.3 13.1 8.4 2.9 7.7 15.7 9.2 19.3 0.6 4.2 0.0 0.7 6.1 4.3 3.4 1.0 3.2 10.4 22.7 5.0 9.3 5.9 4.3 2.4 2.6 4.1 3.7 5.0 26.1 0.2 0.4 0.6 0.3 0.1 0.1 0.1 0.1 0.5 0.3 0.0 0.1 0.3 2.3 0.7 0.1 0.1 0.1 0.5 10.4 16.1 12.1 9.3 8.6 5.5 13.5 12.3 9.8 9.7 13.9 14.0 56.2 9.6 21.9 67.3 8.4 24.9 12.3 35.1 23.9 0.8 10.7 12.4 11.0 5.7 16.3 1.8 2.1 1.1 14.2 11.8 0.0 5.1 0.3 12.3 9.9 53.2 2.4 5.2 0.3 4.0 2.2 6.4 1.1 17.3 34.9 1.0 68.2 7.7 9.3 1.7 0.4 14.8 18.3 10.1 17.5 0.3 1.2 15.2 7.2 18.7 14.3 46.6 24.7 33.7 19.6 2.1 11.5 0.7 5.7 8.4 4.1 3.4 3.8 2.0 6.6 14.7 18.4 0.2 3.3 20.6 29.8 1.1 15.0 1.4 28.8 15.6 NOTCH4 INT3 ENSG00000204301 "Notch receptor 4" Q99466 6 32194843-32224067 "Human disease related genes, Predicted membrane proteins" "Differentiation, Notch signaling pathway, Transcription, Transcription regulation" "Activator, Developmental protein, Receptor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 24.2;breast: 19.8" "Group enriched" "Detected in many" 4 "Adipocytes: 263.8;Endothelial cells: 121.0;Hepatic stellate cells: 188.8" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" NA NA 6400000 "Cluster 82: Adipose tissue - ECM organization" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "unprognostic (2.27e-1)" "unprognostic (2.27e-1)" "unprognostic (6.80e-3)" "unprognostic (9.50e-2)" "unprognostic (1.50e-1)" "unprognostic (1.81e-2)" "unprognostic (3.88e-2)" "unprognostic (3.26e-2)" "unprognostic (1.06e-1)" "unprognostic (1.67e-1)" "unprognostic (1.93e-3)" "unprognostic (2.00e-1)" "prognostic unfavorable (3.84e-4)" "unprognostic (1.31e-2)" "unprognostic (1.66e-1)" "unprognostic (1.56e-1)" "unprognostic (3.13e-1)" 24.2 4.0 0.0 0.5 0.0 0.0 19.8 0.0 0.0 5.8 0.0 3.6 0.5 7.2 3.2 2.7 5.8 0.0 15.8 0.0 0.0 8.5 2.5 18.5 0.4 0.0 0.1 2.8 2.6 0.0 3.0 1.4 0.0 6.0 0.1 0.0 2.6 0.0 5.6 2.8 3.9 0.0 0.0 2.6 3.9 0.9 0.0 0.0 9.6 0.0 0.1 5.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 263.8 0.0 6.1 0.0 6.0 5.2 32.1 9.9 13.6 2.7 2.6 6.6 8.7 0.0 4.2 5.5 4.2 0.4 11.9 0.6 0.0 2.6 46.0 2.6 3.1 121.0 6.0 12.0 0.2 1.1 0.3 4.7 0.0 1.0 0.0 1.8 188.8 2.3 1.7 6.7 0.2 0.8 4.1 9.3 5.2 35.6 7.2 6.8 3.6 10.3 1.6 21.0 0.0 0.0 0.5 0.4 0.3 5.3 0.7 18.0 1.0 0.9 3.1 3.6 0.0 7.8 9.3 5.5 1.9 1.9 1.6 0.3 3.6 3.7 0.9 5.6 NPM1 "B23, NPM" ENSG00000181163 "Nucleophosmin 1" P06748 5 171387116-171411810 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Host-virus interaction" "Chaperone, RNA-binding" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA011384, CAB012983" Supported Enhanced "Nucleoplasm,Nucleoli rim" NA Yes 2000000 "Cluster 30: Non-specific - Translation" "Cluster 50: Non-specific - Ribosome" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 32: Non-specific - Translation" "Nucleoli rim" Nucleoplasm "CAB012983: AB_2533084, HPA011384: AB_1854692" "unprognostic (1.84e-3)" "unprognostic (2.59e-1)" "unprognostic (2.23e-2)" "unprognostic (3.30e-2)" "unprognostic (2.65e-1)" "prognostic unfavorable (7.48e-4)" "prognostic unfavorable (4.82e-6)" "unprognostic (1.86e-2)" "unprognostic (5.25e-3)" "unprognostic (1.39e-1)" "unprognostic (2.26e-3)" "unprognostic (1.27e-1)" "prognostic unfavorable (2.89e-6)" "unprognostic (2.19e-1)" "unprognostic (1.17e-1)" "unprognostic (1.52e-1)" "unprognostic (1.24e-2)" 515.1 370.6 180.7 468.4 190.3 789.2 597.1 188.6 233.5 759.2 195.9 486.6 347.1 656.6 421.5 623.0 596.1 355.4 336.7 169.0 210.7 375.3 370.3 364.5 777.0 196.2 188.6 1384.6 810.6 278.0 314.4 423.7 207.5 386.2 421.2 161.3 385.2 318.5 450.9 386.6 374.1 436.0 213.9 358.1 467.8 284.7 202.6 683.3 510.1 282.4 761.7 524.9 565.4 204.5 2476.2 1522.7 1864.0 2663.1 1073.3 1915.6 2736.9 2111.3 1826.0 2678.1 2387.2 3640.2 1622.2 6243.9 1683.2 1194.5 1927.6 1386.6 2552.2 4639.2 3423.4 2027.9 2027.3 2149.1 1361.9 2740.2 1593.2 4556.3 1790.7 1732.2 1559.7 1845.8 3572.3 2184.3 2019.4 1460.9 2712.8 1406.5 1945.5 2826.5 3071.1 3087.4 2400.7 1280.7 1857.2 2695.2 2051.7 3241.9 2306.9 1583.1 1433.8 1167.4 1210.6 2084.4 4091.0 1288.7 2513.8 2000.7 1289.5 916.7 2114.4 1082.5 3705.3 1161.5 2139.6 3702.2 1403.3 3561.5 1897.0 153.6 287.1 92.3 443.1 311.4 834.2 847.9 832.8 654.3 564.2 634.9 1189.9 973.4 38.0 656.2 264.4 516.8 782.6 1076.1 180.7 190.3 188.6 233.5 169.0 210.7 196.2 188.6 207.5 213.9 202.6 204.5 462.2 346.1 461.1 12.4 911.0 1400.1 1224.1 1692.5 993.1 177.2 779.0 1045.4 243.5 514.8 764.5 323.7 43.8 1647.8 615.9 175.3 743.4 1073.6 135.8 466.3 707.3 568.2 362.1 865.5 15.6 919.2 2021.0 685.9 489.8 544.6 443.8 688.8 383.8 254.1 1071.0 127.9 20.3 656.0 679.5 629.2 817.6 98.6 974.9 557.2 610.1 19.7 862.8 339.2 476.8 14.6 21.2 922.5 370.1 649.9 671.6 1051.5 404.2 911.0 357.4 144.1 433.9 617.8 1074.1 855.7 578.6 907.2 1019.1 1538.8 865.1 1019.5 866.2 967.3 NR4A3 "CHN, CSMF, MINOR, NOR1" ENSG00000119508 "Nuclear receptor subfamily 4 group A member 3" Q92570 9 99821855-99866891 "Cancer-related genes, Disease related genes, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "DNA-binding, Receptor" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 305.7;Langerhans cells: 417.5;Macrophages: 172.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "BJ hTERT+: 24.1;HeLa: 8.0;SK-MEL-30: 18.5;U-266/70: 9.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043360 Uncertain NA NA "Cluster 38: Heart - Muscle contraction" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 41: Macrophages - Immune response" "HPA043360: AB_10961186" "prognostic favorable (5.97e-4)" "unprognostic (6.92e-3)" "unprognostic (5.34e-2)" "unprognostic (2.78e-3)" "unprognostic (1.40e-1)" "unprognostic (9.46e-2)" "unprognostic (2.89e-2)" "unprognostic (3.30e-2)" "unprognostic (2.65e-3)" "unprognostic (1.40e-2)" "unprognostic (2.28e-1)" "unprognostic (3.30e-1)" "unprognostic (2.25e-1)" "unprognostic (1.29e-3)" "unprognostic (6.11e-2)" "unprognostic (2.80e-2)" "unprognostic (1.69e-1)" 43.2 61.2 3.4 14.9 6.3 32.7 7.4 14.1 5.5 11.4 4.2 9.8 0.7 15.7 0.7 4.0 24.8 23.5 67.2 10.2 7.4 7.8 9.0 19.6 1.3 6.3 3.9 46.8 5.2 3.0 21.2 6.5 5.9 15.6 4.0 8.7 2.4 3.3 62.8 2.4 5.8 13.4 1.1 3.5 13.7 1.0 2.9 6.5 7.2 6.2 0.9 32.8 5.1 2.3 0.1 0.1 0.7 0.1 1.3 0.4 1.1 1.5 24.1 0.2 0.2 0.2 0.1 0.2 0.3 0.7 0.5 0.1 0.5 0.0 0.1 1.8 0.3 0.1 8.0 0.0 0.2 0.1 2.3 0.3 0.1 0.5 0.1 0.1 0.0 0.0 0.0 0.5 0.1 0.7 0.0 0.2 0.0 0.2 0.6 0.0 1.1 0.0 0.0 0.1 0.4 0.4 2.7 2.0 18.5 0.2 0.0 0.0 0.1 1.4 0.4 1.8 0.1 9.2 0.1 0.0 0.9 0.1 0.9 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 3.4 6.3 14.1 5.5 10.2 7.4 6.3 3.9 5.9 1.1 2.9 2.3 9.6 12.8 19.7 3.9 101.5 79.5 14.0 3.5 97.9 0.9 44.2 58.5 305.7 4.3 10.0 16.5 10.4 2.3 91.3 2.0 0.0 0.1 1.4 93.1 12.8 16.2 27.3 0.4 13.1 1.7 2.2 60.3 32.6 124.3 120.7 1.2 7.5 0.5 10.5 0.0 6.2 3.8 2.0 12.3 417.5 2.4 1.5 172.8 88.9 2.8 43.0 3.6 1.0 1.5 0.9 0.2 2.3 1.2 37.9 4.7 0.6 0.1 11.4 1.7 0.0 35.7 75.0 1.1 1.6 15.9 59.5 5.6 69.6 1.0 1.7 3.4 NRAS N-ras ENSG00000213281 "NRAS proto-oncogene, GTPase" P01111 1 114704469-114716771 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" Hydrolase "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010157, HPA049830, CAB079912" Uncertain Supported "Plasma membrane" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 16: Pancreatic endocrine cells - Mixed function" "Plasma membrane" "CAB010157: AB_632073, CAB079912: AB_2784586, HPA049830: AB_2680903" "unprognostic (4.75e-2)" "unprognostic (2.81e-1)" "unprognostic (1.09e-3)" "unprognostic (2.11e-2)" "unprognostic (8.59e-3)" "unprognostic (1.14e-1)" "prognostic unfavorable (3.03e-7)" "unprognostic (7.76e-3)" "unprognostic (1.57e-2)" "unprognostic (1.01e-3)" "prognostic unfavorable (1.36e-4)" "unprognostic (6.60e-3)" "prognostic unfavorable (7.87e-4)" "unprognostic (2.68e-1)" "unprognostic (1.30e-1)" "unprognostic (1.16e-1)" "unprognostic (3.33e-2)" 19.0 9.1 10.3 25.7 11.2 58.5 18.0 11.5 12.3 12.5 8.6 27.8 21.5 12.4 7.8 20.7 10.3 17.2 8.3 10.2 12.2 20.9 24.9 18.5 30.4 12.3 12.1 9.6 11.4 9.0 4.3 28.3 12.3 11.4 26.6 6.6 10.9 7.1 7.7 19.8 22.5 14.1 11.7 18.6 21.8 9.6 11.4 39.0 16.1 7.8 29.7 22.2 8.6 13.4 93.7 24.9 65.2 24.9 26.4 56.3 46.5 43.5 48.4 79.5 89.0 50.4 33.9 70.4 56.3 58.9 55.4 26.0 88.2 70.6 113.4 96.5 34.2 47.8 34.5 60.2 52.3 120.0 71.0 51.1 56.1 91.5 66.2 25.0 102.8 54.6 77.3 78.5 71.0 248.9 83.5 46.4 111.0 30.2 17.9 62.9 116.0 44.1 70.6 49.5 39.4 59.0 44.7 36.4 107.1 75.4 31.9 96.2 79.2 43.3 82.2 81.5 90.3 137.7 101.6 81.6 86.4 64.6 159.0 38.7 12.8 12.6 11.7 19.2 10.5 12.8 9.3 11.6 12.6 10.5 9.9 12.9 3.4 15.5 17.6 9.6 13.4 13.1 10.3 11.2 11.5 12.3 10.2 12.2 12.3 12.1 12.3 11.7 11.4 13.4 22.7 16.0 16.5 8.1 25.9 30.7 31.2 23.1 15.4 5.2 18.5 13.6 5.6 18.6 19.3 22.0 8.4 22.4 27.7 49.2 13.7 34.1 3.9 22.9 24.7 29.2 24.6 31.6 5.8 31.5 50.4 16.1 29.0 38.0 31.1 22.2 33.2 29.7 49.2 5.0 5.2 28.1 30.5 44.9 30.7 5.9 8.1 30.4 23.2 9.4 41.6 7.8 22.6 5.0 8.1 51.4 32.9 6.4 39.6 30.6 28.1 39.4 23.1 3.3 6.6 12.8 15.3 7.3 15.4 24.6 36.2 31.2 21.9 13.8 28.8 40.2 NSD2 "KMT3G, MMSET, WHSC1" ENSG00000109685 "Nuclear receptor binding SET domain protein 2" O96028 4 1871393-1982207 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Chromatin regulator, DNA-binding, Methyltransferase, Transferase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Glandular and luminal cells: 20.3;Granulosa cells: 69.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015801, CAB068246, CAB068247" Enhanced Supported Nucleoplasm No No "Cluster 17: Basophils - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "CAB068246: AB_2665690, CAB068247: AB_2665689, HPA015801: AB_1858830" "unprognostic (3.70e-1)" "unprognostic (9.80e-2)" "unprognostic (3.33e-2)" "unprognostic (1.77e-1)" "unprognostic (4.01e-1)" "unprognostic (1.31e-2)" "prognostic unfavorable (2.61e-4)" "unprognostic (3.24e-2)" "unprognostic (6.22e-2)" "unprognostic (7.66e-2)" "unprognostic (2.09e-1)" "unprognostic (9.25e-3)" "prognostic unfavorable (7.19e-4)" "unprognostic (3.89e-2)" "unprognostic (2.95e-1)" "unprognostic (1.31e-1)" "unprognostic (6.15e-2)" 10.1 8.4 12.7 16.5 13.0 54.9 9.9 23.6 15.2 9.4 0.8 19.6 18.6 10.7 7.3 13.6 8.4 8.3 15.8 11.8 11.5 9.8 8.3 12.6 25.4 9.8 8.6 7.7 13.5 12.0 13.8 12.2 12.0 9.7 22.5 28.5 11.6 8.4 16.7 11.6 18.3 12.4 4.4 14.1 12.5 37.2 12.6 59.8 17.4 13.7 24.3 9.7 9.2 14.9 124.0 58.6 168.3 71.2 17.5 26.5 44.2 98.2 85.4 115.2 128.8 44.6 141.4 117.5 31.4 78.0 158.5 50.2 114.4 74.3 195.0 58.3 47.7 151.3 81.7 25.5 18.6 89.5 74.9 9.9 19.8 101.2 89.9 60.1 92.2 123.4 81.7 132.2 95.8 42.1 243.3 99.7 68.8 60.1 77.1 137.8 106.7 42.9 45.4 57.4 115.6 82.7 78.4 29.2 31.7 71.4 68.9 52.2 64.9 109.0 87.4 72.8 188.1 54.1 72.9 113.7 66.0 81.9 108.0 4.0 1.1 1.3 1.0 0.8 1.1 0.9 1.5 1.2 1.2 1.7 1.1 0.8 3.4 1.2 0.5 2.1 2.9 0.7 12.7 13.0 23.6 15.2 11.8 11.5 9.8 8.6 12.0 4.4 12.6 14.9 12.6 12.8 18.4 0.0 4.1 0.0 0.0 0.0 0.0 0.0 15.3 9.1 0.0 0.0 8.1 12.9 0.0 15.7 7.2 0.0 3.9 10.4 0.0 13.0 11.7 6.3 0.0 0.0 0.0 7.1 10.0 6.0 0.0 20.3 2.5 69.3 0.0 0.0 13.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.3 0.0 0.0 5.7 0.0 0.0 0.0 0.0 11.4 0.0 0.0 4.9 0.0 0.0 4.0 7.3 0.0 0.0 0.0 8.4 0.0 0.0 0.0 0.0 3.4 5.2 3.7 0.0 0.0 NTRK1 "MTC, TRK, TRKA" ENSG00000198400 "Neurotrophic receptor tyrosine kinase 1" P04629 1 156815640-156881850 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Differentiation, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "adrenal gland: 7.0;brain: 21.7" "Group enriched" "Detected in some" 10 "Bipolar cells: 22.8;granulocytes: 55.9;Horizontal cells: 57.2" "Cancer enhanced" "Detected in some" "glioma: 1.3" "Group enriched" "Detected in many" 6 "cerebral cortex: 7.6;medulla oblongata: 19.8;pons: 21.7" "Immune cell enriched" "Detected in single" 116 "basophil: 94.5" "Lineage enriched" "Detected in single" 768 "granulocytes: 94.5" "Cell line enriched" "Detected in some" 4 "HMC-1: 82.1" "Region enhanced" "Detected in many" "basal ganglia: 8.4" "Region enriched" "Detected in single" 6 "basal ganglia: 4.1" "CAB004606, HPA035799, HPA076570" Approved Approved Vesicles,Cytosol NA NA 79000 "Cluster 38: Basophils - Unknown function" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 3: HMC-1 - Innate immune response" "Cluster 62: Horizontal cells - Visual perception" "Vesicles, Cytosol" "CAB004606: AB_628397, HPA035799: AB_2674788, HPA076570: " "unprognostic (5.89e-3)" "unprognostic (7.56e-2)" "unprognostic (2.74e-2)" "unprognostic (5.99e-3)" "unprognostic (7.26e-2)" "unprognostic (1.43e-3)" "unprognostic (1.56e-1)" "unprognostic (7.42e-3)" "unprognostic (7.63e-2)" "unprognostic (1.35e-1)" "unprognostic (6.73e-2)" "unprognostic (2.29e-2)" "unprognostic (3.18e-11)" "unprognostic (2.18e-3)" "unprognostic (3.79e-2)" "unprognostic (1.07e-1)" "unprognostic (4.89e-1)" 0.8 7.0 0.7 0.4 1.8 0.7 0.2 1.8 7.6 0.7 0.7 0.8 0.5 1.0 0.0 0.1 0.5 0.4 1.0 0.3 2.8 3.0 0.0 0.5 0.1 19.8 1.5 0.1 0.2 0.0 0.7 0.2 21.7 1.4 0.0 1.9 0.5 0.3 0.4 0.1 0.3 0.6 0.2 0.1 0.5 1.6 0.4 0.3 0.2 0.2 0.0 0.3 0.5 0.6 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.2 0.1 0.0 0.0 0.0 11.9 0.0 14.0 0.0 0.0 0.0 0.0 82.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 4.4 1.6 0.0 0.2 0.0 2.4 0.2 0.0 1.5 2.5 0.0 0.2 0.0 0.5 1.5 18.2 0.0 0.1 0.0 0.3 0.0 0.1 0.3 0.0 1.1 0.0 0.0 3.5 0.6 0.0 0.0 0.0 0.1 94.5 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.2 0.7 1.8 1.8 7.6 0.3 2.8 19.8 1.5 21.7 0.2 0.4 0.6 0.1 0.0 1.3 0.3 0.0 0.0 0.0 0.0 0.0 22.8 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.6 0.2 0.0 4.2 0.7 0.0 0.0 4.3 0.0 0.1 55.9 0.0 0.0 0.0 0.1 57.2 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 2.8 0.0 0.5 0.0 0.5 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.9 3.2 2.7 0.0 0.1 0.0 1.0 0.1 0.0 0.0 NTRK2 TRKB ENSG00000148053 "Neurotrophic receptor tyrosine kinase 2" Q16620 9 84668551-85027054 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, RAS pathway related proteins" "Differentiation, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, Epilepsy, FDA approved drug targets, Obesity" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 230.0;thyroid gland: 116.9" "Cell type enhanced" "Detected in many" "Astrocytes: 1144.3;Excitatory neurons: 750.1;Inhibitory neurons: 877.7;Oligodendrocyte precursor cells: 557.9" "Group enriched" "Detected in many" 5 "glioma: 31.6;head and neck cancer: 8.0;lung cancer: 9.8;thyroid cancer: 26.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 8.7;HaCaT: 3.0;RPTEC TERT1: 9.7;SH-SY5Y: 11.2;SuSa: 4.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007637, CAB010346, HPA074873" Enhanced Supported "Plasma membrane" NA NA 20000000 "Cluster 73: Brain - Neuropeptide signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane" "CAB010346: AB_2155274, HPA007637: AB_1080385, HPA074873: " "unprognostic (2.75e-3)" "unprognostic (3.48e-2)" "unprognostic (1.82e-2)" "unprognostic (3.26e-1)" "unprognostic (9.26e-2)" "unprognostic (2.56e-2)" "unprognostic (1.29e-2)" "unprognostic (9.16e-2)" "unprognostic (6.13e-2)" "unprognostic (1.05e-1)" "unprognostic (4.25e-2)" "unprognostic (2.18e-2)" "unprognostic (2.66e-2)" "unprognostic (1.20e-2)" "unprognostic (1.21e-2)" "unprognostic (1.31e-1)" "unprognostic (1.39e-3)" 40.5 2.7 201.9 1.7 177.8 0.1 62.2 133.3 190.6 9.8 69.8 5.9 0.4 3.9 3.9 8.2 5.6 33.3 15.2 173.3 230.0 20.4 1.8 10.0 3.1 119.4 218.9 9.7 34.3 2.5 10.1 1.8 151.7 4.7 3.6 41.2 14.4 19.1 2.9 11.6 1.6 3.3 116.6 10.9 1.9 2.4 222.1 4.0 116.9 13.8 4.3 4.9 12.0 117.7 0.0 0.0 8.7 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 1.4 0.0 0.2 0.0 0.0 3.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 9.7 0.7 0.7 11.2 0.0 0.0 0.0 4.9 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.1 0.0 0.3 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 201.9 177.8 133.3 190.6 173.3 230.0 119.4 218.9 151.7 116.6 222.1 117.7 17.4 0.0 0.5 1144.3 0.7 56.6 1.0 1.8 93.9 30.3 144.1 116.8 11.4 0.0 0.2 9.2 6.2 0.0 1.0 8.7 27.4 36.1 1.8 1.2 0.4 8.0 0.0 0.0 750.1 0.7 0.1 76.6 0.0 2.3 0.0 0.1 5.0 0.0 0.2 242.3 877.7 0.7 0.0 0.0 14.2 3.6 104.1 1.4 17.8 65.6 0.6 241.0 0.0 557.9 109.5 0.5 7.0 48.2 0.3 0.9 0.0 7.1 1.7 12.2 124.9 9.9 114.4 0.8 2.3 5.2 24.6 0.0 3.3 0.2 7.2 0.9 NTRK3 TRKC ENSG00000140538 "Neurotrophic receptor tyrosine kinase 3" Q16288 15 87859751-88256768 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Differentiation, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 38.8" "Cell type enhanced" "Detected in many" "Astrocytes: 239.3;Early spermatids: 119.6;Excitatory neurons: 360.0;Inhibitory neurons: 277.8;Late spermatids: 148.9;Microglial cells: 177.1;Oligodendrocyte precursor cells: 499.6" "Group enriched" "Detected in some" 4 "glioma: 2.5;testis cancer: 1.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 8 "U-138 MG: 100.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009233, HPA027484, HPA048065" Approved Supported "Nuclear membrane,Nucleoli,Nucleoli rim" NA NA 19000000 "Cluster 10: Brain - Neuronal signaling" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoli, Nucleoli rim" "Nuclear membrane" "CAB009233: AB_632555, HPA027484: AB_2672297, HPA048065: AB_2680245" "unprognostic (1.27e-3)" "unprognostic (1.24e-2)" "unprognostic (1.98e-2)" "unprognostic (2.04e-2)" "unprognostic (1.65e-1)" "unprognostic (3.34e-1)" "unprognostic (3.18e-2)" "unprognostic (2.23e-2)" "unprognostic (2.34e-1)" "unprognostic (3.91e-1)" "unprognostic (2.88e-1)" "unprognostic (1.09e-1)" "unprognostic (5.78e-3)" "unprognostic (6.45e-3)" "unprognostic (1.06e-2)" "unprognostic (1.26e-2)" "unprognostic (2.49e-3)" 12.8 3.7 31.3 0.8 33.2 0.1 7.8 30.7 34.3 12.8 0.0 3.4 0.5 10.4 3.2 1.3 15.0 1.6 5.8 38.8 25.8 5.1 1.0 5.3 1.2 21.5 19.6 7.2 1.0 0.1 12.2 1.0 22.1 9.0 2.0 5.2 6.8 4.3 1.8 4.8 2.2 3.7 10.9 2.5 3.2 9.8 33.4 1.2 3.0 1.9 2.0 8.7 7.4 21.5 0.0 13.1 2.7 0.3 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.2 0.0 0.0 0.3 0.0 0.0 0.0 0.0 1.0 0.0 0.2 0.3 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.3 0.0 0.0 0.0 0.2 0.1 0.0 0.1 0.0 2.5 0.0 0.0 0.0 2.6 0.1 0.1 0.1 0.7 0.1 0.0 0.0 0.0 0.9 0.1 0.1 0.0 100.6 1.8 0.0 1.3 0.0 0.0 0.0 3.0 0.1 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 31.3 33.2 30.7 34.3 38.8 25.8 21.5 19.6 22.1 10.9 33.4 21.5 0.5 0.0 0.0 239.3 0.0 0.5 6.4 0.0 0.0 53.8 3.7 6.0 5.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 119.6 0.4 25.0 1.2 0.0 0.0 360.0 0.0 0.0 5.7 0.0 0.5 0.0 0.0 2.2 0.0 1.0 1.7 277.8 0.0 0.0 0.0 0.6 148.9 3.4 0.6 0.0 177.1 0.0 8.6 0.0 499.6 7.4 0.0 0.0 27.4 0.0 1.3 0.0 0.1 0.0 3.7 52.6 20.3 40.9 11.0 3.7 0.0 0.1 0.1 0.2 0.0 0.0 0.7 OTX2 ENSG00000165588 "Orthodenticle homeobox 2" P32243 14 56799905-56816693 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Developmental protein, DNA-binding" "Disease variant, Microphthalmia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 15 "choroid plexus: 108.8;retina: 279.9" "Group enriched" "Detected in some" 11 "Bipolar cells: 170.6;Cone photoreceptor cells: 168.9;Rod photoreceptor cells: 202.5" "Cancer enriched" "Detected in single" 27 "testis cancer: 11.6" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HAP1: 249.6;hTERT-RPE1: 57.0;NTERA-2: 199.7" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA000633, HPA001123" Uncertain Supported Nucleoplasm,Vesicles NA NA "Cluster 77: Retina - Visual perception" "Cluster 5: NTERA-2 - Transcription" "Cluster 9: Photoreceptor cells - Phototransduction" Nucleoplasm Vesicles "HPA000633: AB_1079538, HPA001123: " "unprognostic (3.82e-1)" "unprognostic (2.56e-2)" "unprognostic (9.28e-2)" 0.0 0.0 4.1 0.0 1.3 0.0 0.0 8.5 0.5 0.0 108.8 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 5.9 2.6 0.0 0.0 0.0 0.0 0.2 8.7 0.0 0.0 0.0 2.5 0.0 2.0 0.0 0.0 279.9 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 12.8 0.0 0.0 0.8 0.0 0.0 0.0 5.6 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 249.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 57.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 199.7 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.1 1.3 8.5 0.5 5.9 2.6 0.2 8.7 2.0 0.1 12.8 5.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 170.6 0.0 0.0 0.3 0.0 0.0 0.0 168.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 5.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 16.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 202.5 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PAX5 BSAP ENSG00000196092 "Paired box 5" Q02548 9 36833269-37034268 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Differentiation, Neurogenesis, Spermatogenesis, Transcription, Transcription regulation" "Developmental protein, DNA-binding" "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 4 "lymphoid tissue: 39.7" "Cell type enriched" "Detected in some" 29 "B-cells: 91.3" "Low cancer specificity" "Detected in some" "Region enhanced" "Detected in many" "midbrain: 6.5" "Group enriched" "Detected in some" 43 "memory B-cell: 39.0;naive B-cell: 26.0" "Lineage enriched" "Detected in single" 52 "B-cells: 39.0" "Group enriched" "Detected in some" 9 "Daudi: 66.6;REH: 194.1;U-698: 87.1" "Region enriched" "Detected in single" 11 "midbrain: 3.9" "Low region specificity" "Detected in all" "CAB026269, CAB026869, HPA056394, HPA068498" Enhanced Supported Supported "Nucleoplasm,Nucleoli fibrillar center,Vesicles,Cytosol" NA NA "Cluster 37: B-cells - Transcription" "Cluster 16: Immune cells - Immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 57: B-cells - Immune response" Nucleoplasm "Nucleoli fibrillar center, Vesicles, Cytosol" "CAB026269: , CAB026869: , HPA056394: AB_2683116, HPA068498: AB_2685997" "unprognostic (4.69e-4)" "unprognostic (3.83e-1)" "unprognostic (9.13e-2)" "unprognostic (1.42e-1)" "unprognostic (2.65e-2)" "unprognostic (1.15e-1)" "unprognostic (2.09e-2)" "unprognostic (2.95e-2)" "unprognostic (2.48e-1)" "unprognostic (2.00e-2)" "unprognostic (1.03e-1)" "unprognostic (2.46e-2)" "unprognostic (1.11e-3)" "unprognostic (3.15e-1)" "unprognostic (8.96e-2)" "unprognostic (6.03e-2)" "unprognostic (1.01e-1)" 0.3 0.1 0.4 14.9 0.3 9.4 0.1 0.5 0.5 0.0 0.2 0.8 0.5 0.2 0.1 0.2 0.0 0.8 0.2 0.3 0.6 0.1 0.2 0.3 39.7 1.1 6.5 0.0 0.0 0.0 0.2 0.1 4.1 0.3 0.8 0.5 1.0 0.0 3.1 0.0 6.6 0.0 0.8 18.7 1.6 0.6 1.9 2.8 0.2 0.0 36.2 1.1 0.0 0.3 0.1 0.3 5.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 66.6 0.1 0.0 0.1 0.2 0.1 0.0 0.0 3.5 0.1 0.0 0.0 0.0 0.0 2.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 1.5 0.1 0.3 1.9 0.3 0.4 194.1 0.4 0.3 0.0 0.0 13.2 2.9 0.1 0.7 0.0 0.0 0.0 7.5 0.2 0.0 0.2 0.1 0.0 0.2 0.1 87.1 0.0 1.5 0.1 0.7 0.0 0.1 0.0 0.1 0.1 39.0 0.0 0.0 0.1 26.0 0.1 0.1 0.1 0.2 0.2 0.1 0.1 0.7 0.4 0.3 0.5 0.5 0.3 0.6 1.1 6.5 4.1 0.8 1.9 0.3 0.0 0.0 0.0 0.7 91.3 0.0 0.3 0.0 0.0 0.1 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.9 0.0 0.0 0.3 0.0 0.4 0.6 0.0 0.0 0.4 0.0 0.0 1.3 0.0 0.0 0.4 0.0 0.0 0.5 0.1 0.0 0.3 0.0 3.1 0.0 0.9 0.0 0.0 0.2 0.5 0.0 0.0 0.3 0.0 0.1 0.0 2.7 0.4 0.0 0.1 0.0 0.1 0.0 0.8 0.1 0.6 0.2 0.2 0.0 0.0 2.0 0.0 0.0 0.3 PAX8 ENSG00000125618 "Paired box 8" Q06710 2 113215997-113278921 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Differentiation, Transcription, Transcription regulation" "Developmental protein, DNA-binding" "Cancer-related genes, Congenital hypothyroidism, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 11 "kidney: 267.9;thyroid gland: 565.5" "Cell type enhanced" "Detected in many" "Collecting duct cells: 246.5;Endometrial ciliated cells: 114.0;Glandular and luminal cells: 228.2;Proximal tubular cells: 128.1" "Group enriched" "Detected in many" 12 "endometrial cancer: 60.6;ovarian cancer: 63.5;renal cancer: 33.2;thyroid cancer: 122.2" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Group enriched" "Detected in many" 7 "EFO-21: 79.7;GAMG: 50.0;RPTEC TERT1: 193.2" "Region enriched" "Detected in some" 4 "pons and medulla: 5.5" "HPA030062, CAB055097, CAB061888, HPA064554" Enhanced Enhanced Nucleoplasm NA NA "Cluster 30: Non-specific - Translation" "Cluster 7: Kidney - Transmembrane transport" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 44: Endometrium - Transcription" Nucleoplasm "CAB055097: AB_2236705, CAB061888: AB_10895719, HPA030062: AB_10603982, HPA064554: AB_2685283" "unprognostic (2.63e-3)" "unprognostic (3.80e-1)" "unprognostic (1.17e-1)" "prognostic unfavorable (1.75e-5)" "unprognostic (7.24e-2)" "unprognostic (5.16e-5)" "unprognostic (1.56e-2)" "unprognostic (3.29e-2)" "unprognostic (1.03e-1)" "unprognostic (2.16e-1)" "unprognostic (4.13e-2)" "unprognostic (4.00e-2)" "unprognostic (3.37e-2)" "unprognostic (3.27e-1)" "unprognostic (2.37e-1)" "unprognostic (8.93e-3)" "unprognostic (1.02e-1)" 2.0 6.0 1.4 0.6 0.9 0.5 1.7 0.1 1.1 14.5 1.7 1.8 0.6 8.8 32.9 2.2 37.5 3.6 2.1 1.0 1.9 267.9 1.2 1.6 1.7 5.2 1.3 1.7 1.0 1.4 1.4 1.9 3.0 1.1 0.9 1.5 1.9 26.1 0.5 1.8 2.4 0.8 3.7 0.8 1.4 2.4 2.3 0.5 565.5 0.3 1.0 2.1 1.0 1.9 9.4 0.8 0.4 0.0 0.4 0.2 3.0 2.6 8.0 0.7 1.2 5.7 1.6 1.7 79.7 0.6 50.0 0.1 1.6 2.6 0.7 3.9 0.0 1.5 0.7 3.4 0.9 0.0 0.0 2.3 0.3 0.6 1.9 9.9 0.1 0.0 1.3 6.2 2.5 1.8 1.0 3.8 0.5 2.2 5.5 0.0 0.6 2.1 193.2 14.4 1.5 0.0 10.4 0.1 5.6 0.0 0.0 3.5 2.7 13.8 0.5 2.6 7.2 1.2 4.6 0.6 11.9 2.0 0.0 0.7 1.0 0.0 0.1 0.6 0.4 1.3 0.4 0.3 0.9 0.5 0.7 0.4 0.2 0.6 0.4 0.3 0.2 0.4 1.4 0.9 0.1 1.1 1.0 1.9 5.2 1.3 3.0 3.7 2.3 1.9 1.3 3.2 2.0 0.7 4.1 0.6 1.9 1.8 7.4 0.6 2.0 1.4 0.9 5.7 3.4 246.5 0.0 2.4 1.6 9.5 46.9 8.5 1.6 114.0 21.8 1.4 4.8 3.0 0.8 2.9 2.4 1.6 4.1 228.2 0.0 1.0 1.1 0.3 5.2 0.0 0.8 3.2 2.0 2.6 2.1 3.9 5.0 5.6 0.0 0.0 2.0 4.0 1.0 0.5 0.2 29.2 7.4 0.4 0.5 1.6 6.3 128.1 0.6 0.9 6.6 3.6 1.7 6.2 7.3 12.5 0.9 0.8 3.1 0.4 3.7 2.2 PBX1 ENSG00000185630 "PBX homeobox 1" P40424 1 164555584-164899296 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Differentiation, Sexual differentiation, Steroidogenesis, Transcription, Transcription regulation" "Activator, Developmental protein, DNA-binding, Repressor" "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 382.3;Excitatory neurons: 475.9;Inhibitory neurons: 405.0;Oligodendrocyte precursor cells: 327.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HEL: 93.0;NTERA-2: 111.5;SK-BR-3: 186.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003505, HPA003881, CAB018768" Supported Enhanced "Nucleoplasm,Nuclear bodies,Cytosol" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 89: Fibroblasts - ECM organization" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "Nuclear bodies, Cytosol" "CAB018768: AB_675783, HPA003505: AB_1855019, HPA003881: AB_1855020" "unprognostic (2.26e-2)" "unprognostic (1.95e-1)" "unprognostic (9.09e-2)" "unprognostic (2.14e-2)" "unprognostic (5.21e-3)" "unprognostic (6.94e-3)" "unprognostic (5.95e-2)" "unprognostic (2.49e-1)" "unprognostic (1.65e-1)" "unprognostic (2.24e-3)" "unprognostic (2.30e-1)" "unprognostic (8.81e-2)" "unprognostic (1.34e-2)" "unprognostic (2.13e-1)" "unprognostic (5.07e-2)" "unprognostic (1.11e-1)" "unprognostic (1.25e-1)" 24.3 32.1 16.5 11.8 22.3 3.1 36.1 10.7 18.0 88.3 1.9 52.3 22.4 136.8 21.6 30.1 74.6 37.6 24.0 15.3 14.1 29.4 7.7 20.7 4.5 8.8 32.7 52.1 48.1 29.5 14.3 19.5 6.7 38.0 19.8 17.1 43.8 53.8 36.3 10.2 19.9 125.2 13.7 10.2 21.9 6.8 12.6 10.9 35.1 26.5 8.1 40.2 41.5 12.1 2.9 74.4 82.4 19.1 50.8 23.3 3.4 25.2 20.9 8.4 6.1 14.2 11.8 0.0 5.5 47.8 4.3 22.8 31.7 8.1 3.6 3.1 31.3 93.0 56.5 0.3 34.7 0.0 22.2 24.4 0.0 5.4 2.1 19.2 0.3 0.0 0.2 0.0 2.2 47.1 0.2 0.6 111.5 3.8 4.5 0.0 21.6 27.0 6.3 44.1 2.5 39.6 27.8 186.1 0.1 71.4 73.2 0.0 0.5 3.7 8.6 24.2 8.1 8.5 61.2 0.1 0.4 0.2 0.4 0.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.6 16.5 22.3 10.7 18.0 15.3 14.1 8.8 32.7 6.7 13.7 12.6 12.1 28.6 22.4 18.6 382.3 2.8 22.8 115.0 39.8 70.6 39.9 129.9 87.8 50.0 98.7 25.3 33.1 110.5 101.3 1.5 29.2 33.2 47.9 91.3 47.7 144.3 47.0 90.9 30.3 475.9 68.7 7.3 126.7 32.1 38.5 71.7 57.6 68.9 18.7 9.7 5.0 405.0 38.2 50.8 1.9 17.5 124.4 63.6 12.1 16.0 125.5 1.6 33.5 1.0 327.2 227.4 31.7 72.5 103.8 2.8 41.5 40.4 57.9 37.3 30.6 39.5 142.0 70.9 2.3 17.5 83.6 28.1 104.7 7.6 168.0 43.7 75.9 PDGFA "PDGF-A, PDGF1" ENSG00000197461 "Platelet derived growth factor subunit A" P04085 7 497258-520296 "Cancer-related genes, Candidate cardiovascular disease genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins" "Developmental protein, Growth factor, Mitogen" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 95.2" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 89.8;Breast myoepithelial cells: 154.9;Paneth cells: 97.0;Smooth muscle cells: 110.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 11.3" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in many" 4 "WM-115: 311.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005579, HPA065024" Approved Approved "Golgi apparatus" "Secreted to blood" NA NA 580000 "Cluster 42: Non-specific - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 17: WM-115 - Nervous system development" "Cluster 48: Smooth muscle cells - ECM organization" "Golgi apparatus" "CAB005579: AB_2161916, HPA065024: " "unprognostic (2.22e-1)" "unprognostic (2.83e-1)" "unprognostic (1.17e-1)" "unprognostic (1.26e-1)" "prognostic unfavorable (1.75e-4)" "prognostic unfavorable (1.78e-4)" "unprognostic (2.63e-3)" "unprognostic (4.37e-2)" "unprognostic (3.02e-1)" "unprognostic (1.96e-1)" "unprognostic (1.85e-1)" "unprognostic (8.26e-2)" "unprognostic (1.07e-2)" "unprognostic (5.87e-2)" "unprognostic (8.35e-2)" "unprognostic (1.02e-1)" "prognostic unfavorable (8.67e-4)" 15.4 8.5 29.3 7.9 36.8 1.7 17.0 36.6 32.4 18.1 20.5 29.2 20.2 26.1 11.2 9.6 21.2 11.4 21.1 27.0 27.5 22.2 8.5 24.9 3.5 46.4 37.5 7.7 71.6 6.6 10.2 26.8 40.7 23.3 14.8 5.2 20.3 11.2 95.2 12.5 25.9 10.2 35.8 16.3 32.1 4.5 36.5 6.6 10.0 15.1 2.4 17.8 15.9 58.8 22.9 15.3 1.5 21.6 4.1 0.7 50.7 5.0 2.9 6.4 4.4 23.8 25.3 0.6 8.7 4.3 2.9 56.6 1.5 69.0 3.4 12.9 2.3 0.3 13.3 8.7 26.9 2.4 2.2 3.0 26.8 3.3 21.3 8.5 12.5 1.3 2.3 3.1 15.8 28.7 3.5 5.0 40.1 8.9 3.3 11.6 1.5 2.5 9.0 5.3 2.1 1.8 76.5 4.2 13.3 47.5 10.7 2.6 37.3 13.6 37.8 8.0 31.0 0.9 1.4 0.8 12.3 7.1 311.4 11.3 1.6 2.4 1.6 1.9 2.2 1.9 1.6 1.5 1.5 1.8 1.9 2.0 4.9 3.4 3.3 2.1 1.8 2.1 29.3 36.8 36.6 32.4 27.0 27.5 46.4 37.5 40.7 35.8 36.5 58.8 15.2 89.8 11.9 11.1 1.5 28.0 20.2 12.1 59.7 15.7 12.7 154.9 29.9 15.7 11.0 14.7 8.4 8.8 1.7 76.9 5.9 15.8 0.3 49.0 4.2 19.4 13.1 0.0 7.7 53.3 5.4 12.3 41.8 35.7 10.8 18.1 21.0 1.0 2.0 32.0 5.9 40.5 2.0 1.3 10.4 0.1 2.1 14.8 14.2 6.5 1.5 0.7 1.0 5.0 27.5 72.6 97.0 6.4 4.4 29.4 47.2 8.5 4.5 2.1 39.5 48.9 110.3 0.5 1.8 9.4 9.8 2.9 3.9 0.2 32.1 18.2 PDGFB "SIS, SSV" ENSG00000100311 "Platelet derived growth factor subunit B" P01127 22 39223359-39244982 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins" "Developmental protein, Growth factor, Mitogen" "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Adipocytes: 75.0;Endothelial cells: 60.6;Langerhans cells: 44.3;Macrophages: 25.5;Pancreatic endocrine cells: 54.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "MAIT T-cell: 10.0" "Lineage enriched" "Detected in many" 7 "T-cells: 10.0" "Cell line enhanced" "Detected in many" "A-431: 33.8;EFO-21: 69.2;HUVEC TERT2: 52.6;SK-BR-3: 53.5;TIME: 68.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011604, HPA011972, CAB018341" Supported Approved Vesicles "Secreted to blood" NA NA 4390000 950000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 38: EFO-21 - Unknown function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Vesicles "CAB011604: AB_2162180, CAB018341: AB_2162187, HPA011972: AB_1855134" "unprognostic (4.96e-2)" "unprognostic (8.94e-3)" "unprognostic (8.41e-2)" "unprognostic (2.66e-1)" "unprognostic (9.84e-2)" "unprognostic (4.46e-3)" "unprognostic (4.34e-1)" "prognostic unfavorable (3.67e-5)" "unprognostic (3.22e-2)" "unprognostic (2.07e-1)" "unprognostic (1.05e-1)" "unprognostic (8.68e-2)" "unprognostic (1.84e-3)" "unprognostic (5.12e-3)" "unprognostic (7.47e-2)" "unprognostic (6.50e-2)" "unprognostic (1.03e-1)" 32.6 6.4 14.7 7.1 10.7 0.4 24.0 10.3 22.2 7.5 4.8 20.6 4.9 8.9 5.2 6.2 7.2 11.7 31.2 12.0 9.8 17.0 3.7 28.1 7.4 13.6 12.4 3.8 8.8 8.9 4.0 40.2 12.0 7.6 3.5 0.8 10.6 5.2 18.7 10.3 9.1 9.2 10.6 6.6 7.9 3.4 16.0 2.1 16.1 11.0 1.6 8.5 6.6 9.4 33.8 2.6 8.4 0.0 0.0 0.0 9.9 0.1 0.4 0.2 0.0 13.0 10.3 0.0 69.2 0.0 3.1 12.4 0.5 2.8 0.0 0.1 0.2 0.7 1.1 4.8 4.3 0.0 18.1 0.0 0.3 0.0 0.4 0.9 52.6 0.0 1.3 6.1 1.9 13.7 0.1 0.1 3.2 8.1 3.4 0.0 0.3 22.8 27.7 0.1 0.2 0.0 0.6 53.5 0.2 6.0 24.3 0.1 68.1 0.1 6.4 0.1 7.5 0.1 0.4 0.3 0.1 1.5 31.3 0.0 0.0 0.0 7.3 0.1 10.0 0.0 4.3 5.6 0.0 0.0 3.6 1.9 0.1 0.0 0.4 1.3 2.3 2.1 14.7 10.7 10.3 22.2 12.0 9.8 13.6 12.4 12.0 10.6 16.0 9.4 75.0 0.0 1.1 0.0 0.6 2.8 1.2 3.8 1.2 0.7 5.1 7.1 3.1 0.0 1.3 7.3 0.0 7.3 4.0 0.1 0.0 20.0 1.3 4.0 0.7 60.6 1.8 0.0 2.8 3.6 6.5 1.6 0.0 5.6 0.0 13.1 16.8 1.4 7.7 0.0 0.9 0.7 4.1 2.6 44.3 0.1 0.6 25.5 1.8 14.0 1.1 0.3 0.0 0.0 0.2 54.7 0.0 0.0 0.0 2.7 0.1 1.9 0.9 0.1 6.6 4.7 9.6 0.3 1.6 1.1 1.4 4.5 2.0 1.2 0.1 0.6 PDGFRA "CD140a, GAS9, PDGFR2" ENSG00000134853 "Platelet derived growth factor receptor alpha" P16234 4 54229280-54298245 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Chemotaxis, Host-virus interaction" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "ovary: 190.2" "Group enriched" "Detected in many" 8 "Endometrial stromal cells: 423.9;Fibroblasts: 256.4;Leydig cells: 449.8;Oligodendrocyte precursor cells: 499.6;Peritubular cells: 408.9" "Cancer enhanced" "Detected in all" "glioma: 30.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 468.1;ASC TERT1: 216.1;BJ hTERT+: 279.4;fHDF/TERT166: 195.9;HHSteC: 156.3;HSkMC: 392.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004947, CAB018143" Supported Approved "Nucleoplasm,Plasma membrane,Cell Junctions" "Intracellular and membrane" NA NA 300000 "Cluster 34: Basophils - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 36: Stromal cells - Cell proliferation" "Nucleoplasm, Plasma membrane, Cell Junctions" "CAB018143: AB_2162351, HPA004947: AB_2732399" "unprognostic (1.67e-1)" "unprognostic (9.35e-2)" "unprognostic (4.59e-3)" "unprognostic (1.60e-1)" "unprognostic (8.92e-2)" "prognostic favorable (9.33e-4)" "unprognostic (1.24e-1)" "unprognostic (2.00e-2)" "unprognostic (1.46e-1)" "unprognostic (2.18e-2)" "unprognostic (2.18e-1)" "unprognostic (7.01e-2)" "prognostic unfavorable (9.79e-6)" "unprognostic (9.58e-3)" "unprognostic (9.87e-2)" "unprognostic (2.16e-2)" "unprognostic (1.72e-3)" 46.0 28.9 13.9 40.4 13.7 1.6 40.1 8.1 12.8 50.8 18.1 37.7 22.4 44.3 21.8 22.5 50.9 38.5 32.1 11.9 11.0 26.5 16.0 37.9 8.5 16.7 11.9 190.2 13.4 3.0 3.7 62.7 15.1 15.0 35.2 5.3 16.6 18.9 9.6 14.8 31.3 48.1 12.1 46.2 29.4 13.6 8.9 7.6 16.5 41.9 7.2 63.9 38.0 20.0 0.1 0.0 1.0 0.8 468.1 216.1 0.5 25.4 279.4 0.1 0.7 67.6 0.5 0.5 0.5 195.9 0.8 0.6 19.6 0.2 0.1 2.6 1.0 0.7 0.7 1.2 156.3 0.3 0.4 392.0 0.0 31.4 0.0 5.4 0.0 0.7 0.6 0.9 1.1 0.1 0.4 1.2 3.5 0.3 1.1 0.5 0.1 0.1 0.0 0.4 0.6 37.9 0.0 0.5 0.2 2.0 0.7 0.1 0.8 84.9 3.2 93.9 0.2 0.4 0.1 0.8 2.6 0.1 2.2 0.7 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 13.9 13.7 8.1 12.8 11.9 11.0 16.7 11.9 15.1 12.1 8.9 20.0 11.1 0.0 0.5 0.3 0.6 17.1 0.6 2.4 1.2 5.5 4.3 3.2 4.8 0.0 0.8 0.0 0.0 1.4 0.9 0.1 1.9 4.2 2.2 11.7 423.9 5.7 0.0 0.0 1.1 6.7 2.0 256.4 5.1 9.0 0.0 2.6 26.0 1.0 3.1 0.0 19.5 0.2 10.2 0.6 27.3 17.2 449.8 5.4 23.2 39.4 4.7 17.5 0.0 499.6 0.4 20.0 0.0 408.9 0.2 0.9 0.0 0.1 0.5 0.6 0.0 25.7 13.9 1.0 3.4 8.1 15.8 1.4 2.5 49.6 0.0 1.0 PDGFRB "CD140b, JTK12, PDGFR, PDGFR1" ENSG00000113721 "Platelet derived growth factor receptor beta" P09619 5 150113839-150155872 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" Chemotaxis "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in many" 4 "Sertoli cells: 1288.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "non-classical monocyte: 1.6" "Low lineage specificity" "Detected in single" "Group enriched" "Detected in many" 4 "ASC diff: 1350.1;ASC TERT1: 462.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003842, CAB018144, HPA028499" Enhanced Supported "Golgi apparatus,Vesicles" NA NA 39000000 "Cluster 14: Monocytes - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 48: Smooth muscle cells - ECM organization" Vesicles "Golgi apparatus" "CAB003842: AB_562328, CAB018144: AB_2162497, HPA028499: AB_10602018" "unprognostic (4.75e-2)" "unprognostic (2.48e-1)" "unprognostic (5.21e-2)" "unprognostic (3.60e-2)" "unprognostic (3.27e-1)" "unprognostic (5.61e-2)" "unprognostic (1.02e-1)" "unprognostic (3.36e-2)" "unprognostic (2.12e-2)" "unprognostic (2.57e-3)" "unprognostic (6.72e-2)" "unprognostic (1.25e-1)" "prognostic unfavorable (5.87e-8)" "unprognostic (3.13e-3)" "unprognostic (1.25e-2)" "unprognostic (5.47e-2)" "prognostic unfavorable (8.11e-4)" 171.2 25.1 25.4 27.5 27.2 0.7 106.3 20.5 33.3 155.9 43.5 41.6 11.9 101.1 24.2 24.1 89.6 124.5 75.7 22.1 23.2 49.7 13.4 98.3 27.5 22.1 24.6 105.5 20.8 21.9 23.0 113.3 22.8 56.2 14.1 6.3 34.5 43.3 38.1 65.0 37.9 68.9 19.4 41.4 27.9 18.4 27.7 8.7 66.5 44.1 13.8 58.3 98.6 21.6 0.1 0.3 8.3 0.4 1350.1 462.7 3.0 48.9 202.3 33.5 56.4 5.4 0.0 0.0 6.4 142.0 19.0 0.1 0.1 0.4 15.8 0.0 0.0 0.1 3.3 3.5 190.7 0.0 0.4 210.0 0.0 46.3 0.6 106.6 0.1 0.1 0.1 5.5 5.5 0.0 0.1 0.6 9.0 0.2 0.2 3.7 2.5 0.2 0.0 0.0 0.1 24.8 0.5 0.1 0.0 38.2 0.1 0.6 0.4 53.7 17.2 23.1 2.8 0.4 0.0 0.3 33.4 0.1 1.5 0.0 0.0 0.0 0.9 0.2 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.0 1.6 0.0 0.0 0.2 25.4 27.2 20.5 33.3 22.1 23.2 22.1 24.6 22.8 19.4 27.7 21.6 50.8 0.0 1.1 81.9 0.5 24.0 0.5 0.0 2.2 6.6 1.4 3.3 17.3 1.5 0.0 1.8 4.2 0.6 6.0 0.3 0.0 0.8 1.6 2.8 99.5 32.2 0.0 0.0 7.9 0.0 1.1 123.5 2.0 2.3 0.0 2.5 6.4 1.9 1.5 0.0 1.3 0.7 0.0 0.0 35.6 10.9 165.3 3.1 24.9 45.0 0.7 50.7 23.7 10.1 3.3 0.1 0.1 203.8 2.3 0.7 0.3 0.1 0.7 2.9 1288.5 6.6 288.3 1.9 1.6 0.8 15.3 0.8 4.8 4.0 0.4 1.1 PIK3CA PI3K ENSG00000121879 "Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha" P42336 3 179148114-179240093 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Angiogenesis, Lipid metabolism, Phagocytosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Excitatory neurons: 126.7;Inhibitory neurons: 122.0;Oligodendrocyte precursor cells: 130.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA009985, CAB017804" Approved Supported Mitochondria,Cytosol NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol Mitochondria "CAB017804: , HPA009985: AB_1079610" "unprognostic (1.81e-1)" "unprognostic (2.77e-1)" "unprognostic (2.18e-1)" "unprognostic (2.69e-3)" "unprognostic (6.49e-3)" "unprognostic (1.43e-1)" "unprognostic (2.65e-2)" "unprognostic (1.00e-2)" "unprognostic (1.03e-1)" "unprognostic (2.37e-1)" "unprognostic (2.57e-3)" "unprognostic (5.21e-2)" "unprognostic (4.50e-2)" "unprognostic (1.16e-2)" "unprognostic (2.48e-1)" "unprognostic (9.74e-2)" "unprognostic (3.82e-2)" 14.7 7.9 3.1 8.1 3.7 12.4 8.5 9.7 8.3 8.7 0.3 6.7 4.2 8.3 4.8 7.9 5.7 8.4 9.5 3.7 3.6 8.2 7.1 7.9 9.2 5.1 4.2 10.3 4.3 11.5 3.4 11.1 5.1 7.3 5.8 12.4 4.5 7.1 7.1 5.5 5.3 8.9 2.3 8.8 5.8 6.1 3.7 13.7 7.9 13.0 9.2 8.6 5.8 6.4 19.9 6.5 9.6 9.2 22.7 27.7 6.5 10.8 16.5 10.9 16.0 5.1 13.0 16.1 21.7 10.8 14.1 5.9 8.4 9.8 16.5 32.0 6.2 22.4 5.2 4.4 10.7 13.1 12.6 16.8 10.6 12.4 15.0 13.4 15.8 12.9 10.6 17.3 18.9 6.9 10.9 8.5 8.0 8.8 7.8 13.9 10.0 16.7 8.5 10.0 5.2 9.9 13.1 10.8 16.1 9.1 19.0 11.1 21.1 10.4 6.5 18.1 13.3 9.3 13.8 29.0 11.3 9.6 5.4 1.3 1.2 0.4 1.2 1.0 0.8 1.5 0.8 0.6 0.8 1.6 1.0 0.8 2.2 0.7 0.9 0.9 0.8 0.3 3.1 3.7 9.7 8.3 3.7 3.6 5.1 4.2 5.1 2.3 3.7 6.4 31.3 32.1 26.8 60.7 28.3 14.7 17.9 11.2 2.2 27.9 14.4 15.2 18.5 5.7 15.9 7.3 31.3 10.2 17.9 8.7 1.9 10.7 2.0 14.1 21.7 25.6 2.4 9.2 126.7 13.9 6.1 23.5 8.6 21.6 31.6 19.9 33.5 21.9 11.1 38.7 122.0 10.3 14.2 23.5 24.3 3.4 32.6 20.9 14.2 75.9 24.5 17.4 18.6 130.2 84.2 16.9 10.8 39.5 15.1 34.6 9.5 14.8 20.1 27.1 26.3 25.7 28.6 11.8 10.2 9.8 14.9 8.8 19.9 19.6 9.2 32.0 PML "MYL, RNF71, TRIM19" ENSG00000140464 "PML nuclear body scaffold" P29590 15 73994673-74047827 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Antiviral defense, Apoptosis, Biological rhythms, Host-virus interaction, Immunity, Innate immunity, Transcription, Transcription regulation" "Activator, DNA-binding, Transferase" "Cancer-related genes, Proto-oncogene, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Adipocytes: 127.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008312, CAB010194, CAB016304" Supported Enhanced "Nuclear bodies" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 82: Adipose tissue - ECM organization" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Nuclear bodies" "CAB010194: AB_2166848, CAB016304: AB_628162, HPA008312: AB_1079643" "prognostic favorable (3.24e-4)" "unprognostic (4.83e-2)" "unprognostic (5.76e-2)" "unprognostic (1.58e-3)" "unprognostic (7.53e-3)" "unprognostic (1.58e-1)" "unprognostic (2.35e-2)" "unprognostic (5.30e-3)" "unprognostic (4.54e-3)" "unprognostic (1.15e-1)" "prognostic unfavorable (3.29e-4)" "unprognostic (2.67e-2)" "prognostic unfavorable (6.27e-8)" "unprognostic (1.58e-2)" "unprognostic (4.17e-2)" "unprognostic (1.02e-1)" "unprognostic (8.99e-2)" 84.4 29.4 14.4 25.6 13.8 38.1 77.0 11.8 16.4 53.7 11.6 46.7 18.4 47.1 7.5 38.3 44.6 21.6 39.3 13.8 13.1 35.4 25.4 75.2 25.6 18.2 13.8 37.5 20.3 8.3 26.8 23.7 14.8 41.5 8.5 3.9 44.2 17.2 22.5 47.4 39.0 19.5 14.6 48.6 35.3 11.3 15.2 17.0 48.1 7.9 15.2 42.7 44.5 13.1 37.2 13.8 11.8 11.4 30.2 43.2 40.6 18.5 31.6 55.9 63.3 14.6 64.2 16.4 63.7 31.6 53.3 66.6 16.3 37.1 7.6 58.0 25.1 35.8 21.3 16.3 36.9 33.9 31.1 83.7 24.8 37.5 19.2 39.3 38.3 26.1 30.6 28.3 32.7 17.3 28.3 52.6 12.8 7.7 25.0 21.6 13.4 30.8 60.3 59.5 10.1 11.1 29.7 16.3 44.8 10.3 12.8 28.7 66.1 56.6 15.5 28.5 38.1 29.4 20.0 8.0 38.9 42.2 18.2 7.4 14.7 23.4 13.0 20.2 9.8 12.4 10.4 14.1 14.5 10.2 8.2 8.5 12.0 14.5 22.6 9.2 14.3 10.1 14.4 13.8 11.8 16.4 13.8 13.1 18.2 13.8 14.8 14.6 15.2 13.1 127.8 16.0 12.2 8.8 24.9 22.9 14.3 30.4 37.5 8.1 13.5 12.8 10.0 5.7 16.7 5.5 2.1 9.4 18.8 13.1 7.9 25.8 3.4 16.0 16.7 48.0 14.3 29.3 4.7 19.1 15.0 20.7 58.1 26.0 12.0 11.5 32.2 11.3 30.8 8.4 4.8 14.3 14.2 20.1 18.5 4.0 27.7 19.6 7.2 7.5 24.6 8.5 20.6 4.5 6.0 62.8 15.5 24.0 21.6 26.2 22.8 10.4 18.3 5.4 39.5 7.7 20.4 1.1 4.0 27.1 19.6 4.9 20.4 16.8 12.1 26.0 PPARG "NR1C3, PPARG1, PPARG2, PPARgamma" ENSG00000132170 "Peroxisome proliferator activated receptor gamma" P37231 3 12287368-12434356 "Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Biological rhythms, Transcription, Transcription regulation" "Activator, DNA-binding, Receptor" "Cancer-related genes, Diabetes mellitus, Disease variant, FDA approved drug targets, Obesity" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 165.1" "Cell type enhanced" "Detected in many" "Adipocytes: 284.1;Extravillous trophoblasts: 217.8;Granulosa cells: 232.9;Urothelial cells: 239.6" "Cancer enhanced" "Detected in all" "urothelial cancer: 33.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 198.7;ASC TERT1: 113.7;BEWO: 247.5;CAPAN-2: 111.6;HSkMC: 118.9;PC-3: 112.0;RT4: 157.5" "Low region specificity" "Detected in many" "Not detected" "Not detected" "CAB004282, HPA051239, HPA063663" Approved Enhanced Nucleoplasm,Vesicles NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 28: BEWO - Transcription regulation" "Cluster 40: Granulosa cells - Unknown function" "Nucleoplasm, Vesicles" "CAB004282: AB_628115, HPA051239: AB_2681400, HPA063663: AB_2685081" "unprognostic (7.35e-3)" "unprognostic (3.27e-2)" "unprognostic (4.05e-2)" "unprognostic (8.37e-2)" "unprognostic (2.41e-2)" "unprognostic (5.27e-3)" "prognostic unfavorable (3.41e-5)" "unprognostic (9.13e-2)" "unprognostic (2.32e-2)" "unprognostic (1.38e-1)" "unprognostic (1.02e-2)" "unprognostic (2.77e-1)" "prognostic favorable (1.59e-8)" "unprognostic (1.51e-2)" "unprognostic (1.46e-1)" "unprognostic (9.68e-3)" "prognostic favorable (5.52e-5)" 165.1 3.9 4.0 8.7 3.0 3.0 74.3 3.2 4.7 9.7 0.6 48.7 23.6 7.0 1.2 6.2 7.0 10.5 14.6 4.0 2.7 14.3 17.1 28.5 4.9 3.7 3.5 14.5 2.8 7.9 0.5 43.6 3.4 5.5 40.6 1.0 5.7 1.7 5.2 6.2 15.1 8.7 3.2 12.0 35.5 6.9 3.5 4.1 13.2 8.1 2.1 67.7 9.1 5.0 44.0 38.6 0.0 0.2 198.7 113.7 247.5 3.7 44.7 5.4 2.1 7.8 111.6 0.0 0.1 4.0 72.9 17.3 14.4 0.7 1.0 106.4 20.3 0.0 8.1 10.3 51.8 0.2 0.1 118.9 9.7 9.8 37.5 20.6 0.7 1.0 0.0 0.0 8.3 11.0 0.1 0.8 0.7 99.2 112.0 0.0 0.0 0.2 30.6 157.5 0.1 1.2 18.8 6.7 2.2 6.7 0.0 34.2 35.0 7.8 10.6 4.6 0.2 0.0 0.1 0.3 3.2 0.5 1.2 0.0 0.3 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 4.0 3.0 3.2 4.7 4.0 2.7 3.7 3.5 3.4 3.2 3.5 5.0 284.1 3.2 7.2 1.6 0.6 1.0 50.5 0.4 4.6 0.9 1.9 2.8 9.2 1.5 2.5 5.5 0.0 110.4 1.8 93.4 1.9 1.1 4.9 5.2 1.4 26.1 8.4 0.0 39.3 0.7 217.8 12.3 83.1 20.8 8.9 232.9 25.7 3.4 49.9 0.0 74.1 21.3 0.0 19.4 4.8 2.2 4.1 19.1 3.6 38.4 1.8 0.6 0.0 6.6 1.2 17.3 84.1 0.0 1.6 42.1 17.0 14.3 1.5 0.2 13.1 1.9 31.3 10.9 22.8 4.6 1.1 88.9 2.2 0.8 24.5 239.6 PRDM1 "BLIMP1, PRDI-BF1" ENSG00000057657 "PR/SET domain 1" O75626 6 105993463-106109939 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Adaptive immunity, Immunity, Innate immunity, Transcription, Transcription regulation" "DNA-binding, Methyltransferase, Repressor, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "esophagus: 55.2" "Cell type enhanced" "Detected in many" "dendritic cells: 199.8;Langerhans cells: 199.2;Plasma cells: 786.9;T-cells: 184.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "eosinophil: 11.1;gdT-cell: 22.1;MAIT T-cell: 34.0;memory CD4 T-cell: 20.5;memory CD8 T-cell: 20.2;naive CD8 T-cell: 11.3;neutrophil: 12.5;T-reg: 29.4" "Group enriched" "Detected in many" 5 "granulocytes: 12.5;T-cells: 34.0" "Cell line enhanced" "Detected in many" "Karpas-707: 212.1;RPMI-8226: 42.4;U-266/70: 81.5;U-266/84: 57.0" "Region enriched" "Detected in single" 6 "olfactory bulb: 3.6" "Low region specificity" "Detected in many" "HPA030033, HPA075427" Approved Approved Nucleoplasm,Nucleoli NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 2: Karpas-707 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" Nucleoli Nucleoplasm "HPA030033: AB_10601050, HPA075427: " "unprognostic (9.60e-2)" "unprognostic (3.28e-2)" "unprognostic (1.71e-1)" "unprognostic (1.98e-2)" "unprognostic (4.03e-1)" "unprognostic (3.77e-2)" "unprognostic (1.04e-1)" "unprognostic (1.49e-1)" "unprognostic (2.42e-1)" "unprognostic (1.81e-1)" "unprognostic (3.50e-2)" "unprognostic (7.56e-2)" "prognostic unfavorable (9.81e-5)" "unprognostic (1.52e-1)" "unprognostic (3.51e-1)" "unprognostic (2.45e-3)" "unprognostic (7.90e-2)" 6.6 2.1 1.6 20.0 1.6 20.3 6.8 5.5 1.8 15.7 3.1 15.2 9.2 17.2 1.3 55.2 5.5 12.7 1.7 1.5 2.8 2.5 4.5 10.1 15.9 3.2 1.8 4.9 1.9 2.5 1.4 5.1 2.7 3.4 17.2 1.3 9.3 2.4 4.3 9.1 12.6 5.5 2.4 13.6 15.2 1.2 2.9 4.2 9.0 2.2 27.8 19.6 20.2 3.4 1.4 0.5 1.1 0.0 1.6 2.1 0.2 7.2 23.3 2.3 3.7 1.4 9.2 2.0 0.4 13.8 0.3 0.5 0.0 3.6 2.5 21.7 0.1 0.4 4.9 0.0 3.6 0.8 1.6 2.3 11.6 3.3 9.7 0.7 2.9 1.0 1.4 212.1 0.4 0.0 0.1 0.5 0.8 1.4 0.0 0.5 0.0 42.4 2.1 0.3 0.0 0.3 1.0 0.9 0.0 1.6 1.0 2.4 1.5 3.1 1.8 2.1 7.2 81.5 57.0 4.9 5.1 1.3 2.1 2.4 0.8 11.1 22.1 1.2 34.0 2.5 20.5 20.2 0.5 1.0 1.8 11.3 12.5 4.7 0.3 0.4 29.4 2.6 1.6 1.6 5.5 1.8 1.5 2.8 3.2 1.8 2.7 2.4 2.9 3.4 93.1 0.0 5.1 0.3 42.1 19.5 8.6 15.0 3.4 0.6 2.8 3.4 1.5 0.0 19.1 3.7 52.1 0.7 199.8 129.8 0.0 0.3 0.9 15.9 101.0 41.1 1.8 6.1 1.8 0.2 0.7 18.5 19.4 62.6 3.8 9.9 6.4 2.5 19.8 0.0 19.2 15.0 10.2 38.0 199.2 0.3 0.0 64.5 37.4 23.4 30.4 0.5 89.6 0.5 0.1 7.8 103.7 1.2 786.9 4.0 3.2 0.3 13.0 1.1 0.0 5.3 30.1 0.5 2.3 43.9 41.5 0.7 184.3 1.6 8.7 91.9 PTCH1 "BCNS, NBCCS, PTCH" ENSG00000185920 "Patched 1" Q13635 9 95442980-95517057 "Cancer-related genes, Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Receptor "Cancer-related genes, Disease variant, Holoprosencephaly, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "cervix: 26.7" "Cell type enhanced" "Detected in many" "Late spermatids: 237.5;Leydig cells: 191.0;Peritubular cells: 444.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "gdT-cell: 6.1" "Lineage enriched" "Detected in single" 9 "T-cells: 6.1" "Cell line enhanced" "Detected in many" "NTERA-2: 29.6;WM-115: 71.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013717, HPA075072" Uncertain Approved "Golgi apparatus" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 57: Non-specific - Angiogenesis" "Cluster 17: WM-115 - Nervous system development" "Cluster 52: Non-specific - Transcription" "Golgi apparatus" "CAB013717: , HPA075072: AB_2686733" "unprognostic (1.46e-1)" "unprognostic (1.06e-1)" "unprognostic (3.16e-1)" "unprognostic (1.79e-2)" "unprognostic (3.22e-2)" "unprognostic (9.01e-2)" "unprognostic (2.13e-1)" "unprognostic (3.54e-3)" "unprognostic (2.63e-1)" "unprognostic (8.66e-3)" "unprognostic (1.52e-2)" "unprognostic (2.82e-1)" "unprognostic (1.13e-6)" "unprognostic (8.63e-2)" "unprognostic (4.40e-2)" "unprognostic (2.76e-1)" "unprognostic (2.82e-1)" 3.0 3.5 9.5 4.0 11.6 0.7 2.8 24.6 5.6 26.7 2.7 11.3 8.1 15.6 2.7 2.9 7.1 8.1 2.9 4.7 17.8 4.6 2.2 5.5 2.2 16.0 12.7 5.0 6.4 2.5 2.1 3.8 8.0 6.8 12.3 8.3 7.5 4.0 3.0 3.2 11.6 2.4 7.0 3.3 12.5 14.5 24.0 2.1 4.7 4.8 3.0 7.2 2.9 4.5 10.1 4.7 20.3 12.9 3.0 5.0 11.4 1.9 1.7 2.2 1.4 4.9 4.8 8.0 3.3 3.8 4.4 22.3 11.7 1.6 1.4 7.9 7.8 0.0 4.8 2.3 2.7 0.2 4.2 4.7 2.4 2.2 1.4 4.3 4.2 3.5 7.3 9.1 1.0 1.9 0.1 3.2 29.6 7.2 1.8 0.0 15.5 4.2 1.6 1.5 13.8 7.0 7.1 6.8 2.9 18.8 1.8 2.1 1.1 2.6 12.9 13.6 1.5 18.0 16.8 5.3 3.8 3.9 71.0 0.0 0.0 0.0 6.1 0.0 3.3 0.7 1.1 2.5 0.0 0.2 1.9 2.2 0.0 0.3 0.0 0.0 1.2 1.7 9.5 11.6 24.6 5.6 4.7 17.8 16.0 12.7 8.0 7.0 24.0 4.5 6.0 0.0 6.4 49.0 3.0 4.0 2.7 3.0 4.6 20.3 3.5 4.6 5.9 25.8 2.7 0.0 41.7 3.0 11.8 2.0 5.9 3.5 88.4 12.2 89.8 5.4 21.7 0.4 15.2 4.2 1.9 27.2 1.1 11.0 1.3 2.6 6.4 2.9 0.8 20.2 10.7 11.0 4.1 0.9 1.2 237.5 191.0 1.4 12.4 4.7 0.8 55.6 54.6 39.7 20.5 2.4 3.1 444.5 3.1 4.9 3.1 1.6 5.5 13.4 39.5 4.8 9.4 4.4 35.5 3.0 4.4 1.4 6.5 71.7 4.7 1.4 PTEN "BZS, MHAM, MMAC1, PTEN1, TEP1" ENSG00000171862 "Phosphatase and tensin homolog" P60484 10 87863625-87971930 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Lipid metabolism, Neurogenesis" "Hydrolase, Protein phosphatase" "Autism spectrum disorder, Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 60.5" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB004076, HPA031335" Approved Supported Nucleoplasm,Cytosol "Intracellular and membrane" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 82: Adipose tissue - ECM organization" "Cluster 24: NB-4 - Immune response" "Cluster 48: Smooth muscle cells - ECM organization" Nucleoplasm Cytosol "CAB004076: AB_390810, HPA031335: AB_2797221" "unprognostic (8.72e-2)" "unprognostic (2.45e-1)" "unprognostic (5.43e-1)" "unprognostic (1.50e-2)" "unprognostic (3.71e-2)" "unprognostic (1.30e-1)" "unprognostic (2.18e-1)" "unprognostic (2.08e-1)" "unprognostic (2.07e-1)" "unprognostic (6.87e-2)" "unprognostic (9.77e-2)" "unprognostic (2.71e-1)" "prognostic unfavorable (7.35e-4)" "unprognostic (1.57e-1)" "unprognostic (2.73e-1)" "unprognostic (6.54e-3)" "unprognostic (2.41e-1)" 64.0 25.4 17.8 18.6 19.3 12.9 47.6 34.5 23.4 54.8 15.6 28.1 12.9 27.4 18.6 28.3 35.2 15.6 29.7 20.4 18.4 22.6 39.2 39.5 21.4 16.6 17.8 28.0 33.2 11.9 17.3 30.5 16.4 26.3 14.6 30.0 19.6 16.5 23.7 25.9 24.5 22.2 14.5 40.0 25.6 28.2 19.7 31.8 26.1 14.0 16.5 28.1 38.4 17.6 23.5 10.8 12.3 11.2 28.5 19.7 10.9 12.5 28.0 14.5 20.4 10.9 28.0 28.1 8.0 20.9 8.3 14.1 16.6 14.3 22.8 14.1 4.7 9.3 28.5 13.8 30.1 31.9 15.3 13.5 38.7 18.0 23.7 60.3 20.8 17.7 7.0 72.6 13.5 18.1 17.8 56.3 4.6 19.9 0.0 27.6 6.4 20.8 22.9 13.4 4.5 19.9 16.6 7.9 23.0 9.7 21.9 45.2 17.9 44.6 10.8 18.3 10.1 23.9 32.9 30.7 14.6 29.2 2.9 21.3 14.2 25.8 6.8 21.8 7.2 7.9 7.2 6.6 10.3 6.8 8.3 8.3 60.5 8.9 15.6 8.2 7.0 4.5 17.8 19.3 34.5 23.4 20.4 18.4 16.6 17.8 16.4 14.5 19.7 17.6 67.2 35.3 63.3 83.6 48.3 56.1 57.4 31.5 47.3 113.0 49.4 41.9 46.5 57.2 31.2 29.5 39.6 25.8 64.4 57.7 33.2 24.7 70.1 40.0 114.5 56.0 31.2 52.0 141.0 30.0 62.2 79.3 39.8 33.6 25.4 39.6 53.9 64.1 35.0 45.4 132.4 44.7 12.2 206.1 97.2 92.1 56.8 105.2 62.2 196.8 101.5 61.6 44.3 139.2 95.7 30.6 39.7 54.5 39.3 45.1 50.1 38.0 31.2 61.2 92.1 66.4 170.7 33.5 25.4 45.2 60.1 57.3 46.3 44.7 46.1 64.0 PTGES2 "C9orf15, FLJ14038" ENSG00000148334 "Prostaglandin E synthase 2" Q9H7Z7 9 128120693-128128462 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism" Isomerase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in all" 4 "Cardiomyocytes: 700.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020631, HPA020733" Approved Approved Mitochondria No No "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 54: Cardiomyocytes - Muscle contraction" Mitochondria "HPA020631: AB_1855887, HPA020733: AB_2670508" "unprognostic (1.23e-1)" "unprognostic (1.86e-2)" "unprognostic (1.60e-1)" "unprognostic (1.95e-2)" "unprognostic (1.55e-1)" "unprognostic (1.68e-2)" "unprognostic (5.13e-3)" "unprognostic (2.56e-1)" "unprognostic (1.57e-1)" "unprognostic (7.10e-2)" "unprognostic (2.81e-2)" "unprognostic (4.33e-2)" "prognostic favorable (5.83e-7)" "unprognostic (2.10e-2)" "unprognostic (1.46e-1)" "unprognostic (1.10e-1)" "unprognostic (1.05e-1)" 18.1 49.8 31.6 15.6 33.9 6.5 16.0 29.1 45.8 18.1 32.4 30.6 27.5 21.6 4.0 35.3 17.6 11.4 95.0 35.6 33.0 36.4 37.7 14.8 17.6 31.5 31.5 16.1 37.6 35.2 41.4 9.7 32.1 24.6 9.2 10.0 26.1 16.8 117.9 20.9 23.8 7.5 27.3 21.1 29.6 14.5 31.5 11.9 23.5 78.7 9.7 22.3 22.0 31.7 46.1 114.0 15.5 54.4 13.5 12.8 47.9 30.7 20.6 48.6 24.9 86.9 75.6 43.5 45.7 15.9 36.9 108.8 22.5 47.1 6.5 28.3 62.3 21.0 92.7 79.5 41.0 42.1 39.5 18.6 32.3 39.5 26.9 14.2 31.6 47.8 50.2 26.4 16.7 130.0 56.9 75.6 42.7 58.7 113.9 39.6 26.5 111.6 32.8 33.1 69.1 45.6 47.3 86.3 34.2 6.7 78.7 23.5 34.0 46.3 50.2 62.8 63.1 48.9 25.5 38.3 39.1 33.2 44.5 1.4 3.3 0.7 3.1 3.7 3.8 3.8 2.2 3.5 4.3 2.7 2.4 3.0 0.6 2.7 1.8 5.8 3.1 1.9 31.6 33.9 29.1 45.8 35.6 33.0 31.5 31.5 32.1 27.3 31.5 31.7 18.8 16.0 6.4 10.4 32.0 22.9 38.1 32.7 25.0 37.8 34.2 36.3 700.2 51.5 25.9 23.9 20.9 82.1 30.8 86.1 146.8 74.6 2.1 12.7 20.9 29.4 45.1 13.2 15.5 51.8 62.1 32.7 46.4 17.3 14.7 31.9 13.9 37.8 57.6 37.0 15.8 62.2 46.8 25.3 43.6 4.8 30.7 30.8 56.9 3.7 105.7 21.9 38.1 12.1 7.2 57.6 60.4 21.8 45.4 68.0 93.4 99.3 9.3 44.8 19.7 17.8 37.2 3.6 45.6 48.3 24.6 66.6 25.6 84.1 105.5 52.9 PTGS2 COX2 ENSG00000073756 "Prostaglandin-endoperoxide synthase 2" P35354 1 186671791-186680922 "Cancer-related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism" "Dioxygenase, Oxidoreductase, Peroxidase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 116.7;seminal vesicle: 127.4;urinary bladder: 162.5" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 342.9;Fibroblasts: 270.7;granulocytes: 347.6;Langerhans cells: 305.6;Macrophages: 173.1;Urothelial cells: 151.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 16 "neutrophil: 11.7" "Lineage enriched" "Detected in single" 16 "granulocytes: 11.7" "Cell line enriched" "Detected in many" 4 "BJ hTERT+: 405.5" "Region enhanced" "Detected in many" "hippocampal formation: 15.1" "Low region specificity" "Detected in many" "CAB000113, HPA001335" Enhanced Approved "Endoplasmic reticulum,Vesicles" "Intracellular and membrane" NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 41: Macrophages - Immune response" "Endoplasmic reticulum, Vesicles" "CAB000113: , HPA001335: AB_1079712" "unprognostic (1.36e-3)" "unprognostic (9.97e-3)" "unprognostic (3.97e-2)" "unprognostic (3.31e-2)" "unprognostic (1.55e-1)" "unprognostic (1.11e-1)" "unprognostic (5.96e-2)" "unprognostic (9.50e-2)" "unprognostic (9.03e-3)" "unprognostic (2.81e-1)" "unprognostic (3.24e-2)" "unprognostic (3.07e-2)" "prognostic unfavorable (9.79e-4)" "unprognostic (8.04e-3)" "unprognostic (4.38e-2)" "unprognostic (8.89e-2)" "unprognostic (3.74e-2)" 17.0 7.9 1.4 13.9 2.5 116.7 3.0 1.1 4.1 62.2 2.7 14.9 2.6 8.9 0.7 6.9 5.1 31.6 11.7 1.9 1.4 10.2 8.0 34.3 8.9 2.0 1.6 2.6 2.2 5.6 3.1 8.4 1.5 25.0 9.9 0.3 1.2 127.4 0.4 1.6 3.6 12.2 1.9 2.8 14.8 0.2 1.8 5.2 3.2 6.5 0.6 162.5 2.2 2.6 0.0 21.8 0.1 0.0 2.5 2.1 0.0 93.4 405.5 0.6 3.6 15.0 17.2 0.0 0.0 0.1 2.5 12.2 0.0 7.6 1.3 0.0 0.0 0.8 2.2 0.0 13.2 0.0 0.2 0.8 2.7 11.3 28.7 1.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 3.8 0.0 0.0 0.0 0.0 0.0 5.5 1.5 0.0 1.0 0.0 0.9 2.7 0.0 0.1 1.5 19.3 0.6 13.5 0.6 0.2 0.0 0.0 27.7 0.4 2.3 0.0 0.3 0.2 0.0 0.7 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 11.7 0.0 0.4 0.0 0.0 0.0 1.4 2.5 1.1 4.1 1.9 1.4 2.0 1.6 1.5 1.9 1.8 2.6 5.2 342.9 77.7 0.0 7.4 118.8 59.1 72.8 12.5 0.0 2.6 12.8 2.5 0.0 79.7 0.0 0.0 0.2 4.2 0.3 0.0 0.8 0.2 50.0 9.9 31.1 1.2 3.6 3.8 0.2 0.3 270.7 2.0 98.9 347.6 3.8 13.6 0.2 12.1 0.0 1.0 1.0 8.2 21.0 305.6 0.0 0.0 173.1 35.6 3.7 3.4 0.1 0.0 0.0 0.1 4.9 0.1 0.0 2.0 122.6 0.2 0.3 13.1 0.3 0.0 1.8 12.8 0.1 0.4 3.3 28.4 0.5 10.8 3.7 1.2 151.6 PTPN11 "BPTP3, NS1, PTP2C, SH-PTP2, SHP-2, SHP2" ENSG00000179295 "Protein tyrosine phosphatase non-receptor type 11" Q06124 12 112418351-112509918 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Hydrolase, Protein phosphatase" "Cancer-related genes, Deafness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB005377 Approved Supported "Nucleoplasm,Nucleoli rim,Actin filaments,Cytosol" NA NA 74000 "Cluster 6: Non-specific - Transcription" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 54: Cardiomyocytes - Muscle contraction" "Nucleoplasm, Nucleoli rim" "Actin filaments, Cytosol" "CAB005377: AB_632401" "unprognostic (2.18e-3)" "unprognostic (1.73e-3)" "unprognostic (5.62e-2)" "unprognostic (1.19e-1)" "unprognostic (1.63e-2)" "unprognostic (2.27e-1)" "unprognostic (6.05e-2)" "unprognostic (4.25e-2)" "unprognostic (3.55e-2)" "unprognostic (1.88e-1)" "unprognostic (2.22e-2)" "unprognostic (8.85e-2)" "unprognostic (3.75e-3)" "unprognostic (1.66e-1)" "unprognostic (2.46e-1)" "unprognostic (3.62e-2)" "unprognostic (1.80e-2)" 62.9 36.6 74.6 34.7 91.7 46.3 37.6 72.7 115.7 37.9 38.4 32.5 27.6 37.8 28.7 38.9 24.3 29.4 68.7 66.1 85.6 39.7 53.0 34.4 35.6 79.0 84.1 26.2 31.6 53.4 16.1 38.0 85.7 35.2 30.6 51.8 25.9 42.4 75.1 32.1 26.1 45.7 83.4 26.7 30.4 18.2 81.7 35.5 46.8 64.0 32.5 40.1 23.5 106.3 116.9 107.6 77.0 73.4 109.7 106.1 92.7 136.4 148.2 105.5 78.5 107.7 43.4 124.5 69.4 127.4 66.7 68.1 100.1 121.6 173.8 93.1 85.0 181.5 102.6 59.8 109.2 145.8 108.0 86.6 119.6 113.6 159.8 101.3 88.7 92.0 140.2 41.3 103.3 83.2 101.0 69.7 94.1 112.3 73.4 102.4 114.6 70.5 97.3 126.7 53.3 66.1 133.7 99.8 85.2 77.6 114.8 97.8 108.1 122.9 110.0 74.2 121.8 79.4 141.6 120.2 102.2 99.7 117.7 32.2 11.7 16.8 14.8 10.2 14.0 18.1 13.3 12.4 13.6 20.8 15.3 11.9 10.7 12.6 13.7 18.3 10.9 7.2 74.6 91.7 72.7 115.7 66.1 85.6 79.0 84.1 85.7 83.4 81.7 106.3 49.0 60.9 68.2 27.7 25.8 25.6 39.9 25.3 20.5 29.9 40.5 32.4 131.6 24.3 41.8 36.8 16.7 23.5 34.2 25.4 33.2 37.5 63.1 31.3 92.6 46.2 13.1 21.7 67.6 42.8 25.3 35.8 21.9 40.9 28.4 33.1 26.0 101.5 26.8 13.5 54.7 22.0 18.3 33.3 21.6 28.5 51.6 31.8 14.2 40.3 31.1 59.8 29.9 32.6 73.0 59.3 19.6 79.7 37.0 73.4 16.6 39.8 23.5 22.2 32.9 58.2 49.2 7.1 6.6 37.5 27.4 35.2 31.7 30.5 22.2 66.8 RARB "HAP, NR1B2, RRB2" ENSG00000077092 "Retinoic acid receptor beta" P10826 3 25174332-25597932 "Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "DNA-binding, Receptor" "Cancer-related genes, Disease variant, FDA approved drug targets, Microphthalmia, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 41.4;Excitatory neurons: 66.8;Inhibitory neurons: 92.6;Microglial cells: 29.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC diff: 13.7;HEK 293: 16.0;hTERT-RPE1: 82.3;WM-115: 36.5" "Region enriched" "Detected in all" 9 "basal ganglia: 109.2" "CAB002617, HPA004174" Enhanced Enhanced Nucleoplasm NA NA "Cluster 82: Adipose tissue - ECM organization" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "CAB002617: , HPA004174: AB_1079744" "unprognostic (2.04e-2)" "unprognostic (3.53e-2)" "unprognostic (1.93e-1)" "unprognostic (1.09e-1)" "unprognostic (1.56e-1)" "unprognostic (6.72e-2)" "unprognostic (1.30e-2)" "unprognostic (2.70e-2)" "unprognostic (2.43e-1)" "unprognostic (4.71e-2)" "unprognostic (1.62e-1)" "unprognostic (2.86e-1)" "prognostic favorable (3.43e-5)" "unprognostic (9.24e-3)" "unprognostic (2.28e-1)" "unprognostic (9.99e-2)" "unprognostic (6.56e-3)" 4.1 7.0 3.5 2.6 15.0 0.0 6.9 2.2 6.6 9.3 7.2 6.0 1.7 7.4 6.7 7.9 6.0 5.3 14.0 3.5 1.4 15.1 6.5 5.3 6.7 3.4 1.7 11.5 1.3 6.0 7.5 14.4 0.9 12.5 2.2 13.6 13.1 11.2 2.4 1.1 2.0 5.9 1.4 4.9 3.9 0.6 2.4 1.2 9.1 5.3 4.2 7.2 6.1 3.7 0.0 1.9 1.2 6.4 13.7 3.6 0.0 1.6 0.8 0.0 0.6 0.3 0.1 0.1 0.2 2.5 0.3 0.4 0.0 0.3 0.0 0.1 16.0 0.1 0.1 1.1 0.3 0.2 0.1 7.1 0.0 0.0 0.0 82.3 13.4 0.1 0.1 5.6 0.1 0.1 0.0 0.1 0.3 0.1 0.0 0.3 0.0 0.0 0.0 0.2 0.6 8.3 0.0 0.2 0.1 9.1 0.0 0.1 0.0 1.1 0.1 2.1 7.0 0.2 0.0 0.1 5.6 0.2 36.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.5 15.0 2.2 6.6 3.5 1.4 3.4 1.7 0.9 1.4 2.4 3.7 2.4 0.0 0.5 41.4 0.3 0.1 18.0 6.4 1.8 4.5 1.7 7.5 12.0 12.8 14.9 11.0 25.0 0.2 0.8 0.0 0.0 1.6 1.5 8.3 4.2 10.5 0.0 0.0 66.8 0.9 0.1 6.8 7.7 3.0 0.0 0.1 22.1 2.1 0.4 5.0 92.6 0.0 2.0 1.9 0.4 1.2 0.0 0.3 0.0 29.0 0.0 24.8 0.0 19.6 2.9 1.4 0.0 0.0 0.2 10.2 0.6 0.6 9.2 6.3 0.0 2.9 9.7 0.2 1.0 6.6 0.1 0.3 0.5 0.2 0.2 9.7 RASSF1 "123F2, NORE2A, RDA32, REH3P21" ENSG00000068028 "Ras association domain family member 1" Q9NS23 3 50329782-50340980 "Human disease related genes, Predicted intracellular proteins, RAS pathway related proteins" "Cell cycle" "Tumor suppressor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "dendritic cells: 116.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 252.6" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040735 Approved NA Yes "Cluster 46: Basophils - DNA binding" "Cluster 82: Adipose tissue - ECM organization" "Cluster 24: NB-4 - Immune response" "Cluster 63: NK-cells & T-cells - Immune response" "HPA040735: AB_10671692" "unprognostic (5.02e-2)" "prognostic favorable (2.64e-4)" "unprognostic (3.05e-1)" "unprognostic (2.95e-2)" "unprognostic (1.00e-3)" "prognostic favorable (2.60e-4)" "prognostic unfavorable (9.77e-4)" "unprognostic (3.80e-2)" "unprognostic (2.11e-1)" "unprognostic (1.07e-2)" "unprognostic (1.54e-1)" "unprognostic (3.47e-2)" "prognostic unfavorable (8.58e-5)" "unprognostic (4.27e-2)" "unprognostic (2.29e-1)" "unprognostic (1.11e-1)" "unprognostic (9.71e-2)" 50.1 18.9 19.2 23.2 19.5 84.3 46.0 19.6 20.1 44.1 18.1 28.4 15.6 29.7 11.1 26.2 35.4 21.5 47.7 18.4 19.2 39.0 24.7 61.2 39.5 20.8 20.0 31.2 35.3 7.5 22.2 25.8 20.4 31.6 11.6 6.1 30.2 11.8 28.5 38.9 39.6 18.1 20.7 72.3 31.7 38.5 20.4 16.3 29.7 14.3 25.5 32.3 37.4 22.1 37.4 15.1 11.1 18.5 25.0 33.8 16.2 62.5 40.9 52.6 41.8 34.7 27.3 18.0 9.4 67.3 23.6 19.6 23.3 26.1 28.3 44.6 15.2 61.8 51.9 18.4 28.6 61.2 65.2 26.1 18.1 52.0 18.4 15.4 23.7 21.8 26.2 40.7 24.1 13.1 23.3 81.9 14.7 31.2 44.9 19.0 11.4 41.4 15.7 10.8 13.0 23.9 55.6 37.2 41.5 11.2 22.3 59.2 22.9 36.1 27.2 52.0 31.3 16.5 11.7 39.4 20.3 75.6 66.1 252.6 23.3 79.5 77.0 41.5 48.3 44.3 24.6 55.3 24.9 33.6 15.7 37.7 18.4 64.6 59.1 18.5 27.5 42.0 19.2 19.5 19.6 20.1 18.4 19.2 20.8 20.0 20.4 20.7 20.4 22.1 76.6 16.0 8.1 4.6 50.7 73.8 36.3 22.6 34.1 11.6 32.7 22.9 14.3 12.8 14.4 1.8 14.6 27.5 116.1 12.2 5.9 23.1 2.4 16.5 16.3 47.4 16.7 33.2 3.8 26.5 28.1 29.1 27.0 17.6 57.1 9.0 26.0 4.3 38.6 3.3 3.8 19.4 22.4 27.7 43.8 10.4 19.0 28.7 90.7 9.4 23.2 6.1 93.7 2.0 6.0 40.9 17.4 14.7 63.8 24.7 12.1 10.2 7.7 10.1 26.3 19.3 50.4 33.1 11.0 19.2 50.2 16.6 67.2 9.0 15.2 21.3 RB1 "OSRC, PPP1R130, RB" ENSG00000139687 "RB transcriptional corepressor 1" P06400 13 48303744-48599436 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Host-virus interaction, Transcription, Transcription regulation" "Chromatin regulator, DNA-binding, Repressor" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Langerhans cells: 198.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "MOLT-4: 187.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000095, CAB016687, HPA050082" Supported Supported Nucleoplasm NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 16: Immune cells - Immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 41: Macrophages - Immune response" Nucleoplasm "CAB000095: , CAB016687: AB_1622010, HPA050082: AB_2681008" "unprognostic (4.24e-3)" "unprognostic (1.00e-1)" "unprognostic (3.62e-2)" "unprognostic (4.67e-2)" "unprognostic (2.04e-2)" "unprognostic (3.86e-1)" "unprognostic (4.69e-2)" "unprognostic (7.08e-2)" "unprognostic (1.59e-1)" "prognostic unfavorable (6.92e-4)" "unprognostic (4.06e-2)" "unprognostic (9.40e-2)" "unprognostic (4.67e-2)" "unprognostic (1.79e-1)" "unprognostic (9.99e-2)" "unprognostic (2.31e-1)" "unprognostic (1.70e-1)" 20.7 18.7 8.9 22.8 9.7 19.3 17.8 12.0 13.0 18.8 10.9 15.1 14.6 15.7 21.2 21.9 13.1 17.3 17.8 8.5 10.9 18.4 14.5 18.1 30.7 13.9 10.3 11.5 9.2 20.5 6.5 24.9 13.4 15.1 17.1 12.5 16.9 15.9 19.0 23.6 15.6 18.3 11.6 24.8 16.3 12.9 9.3 34.2 22.4 21.2 30.1 19.8 10.6 15.1 29.1 15.8 40.9 44.2 19.8 22.8 18.5 56.6 45.9 57.4 48.3 13.4 49.8 37.3 12.8 37.4 31.7 39.6 53.7 44.8 86.6 53.0 20.8 68.5 29.4 22.7 21.1 59.5 62.0 12.9 27.0 37.3 47.1 47.8 40.1 90.1 23.4 29.6 66.4 13.7 187.2 29.8 20.0 65.6 17.3 79.8 41.1 43.0 59.6 27.6 2.0 41.8 55.1 27.3 46.2 36.2 29.8 76.3 32.1 35.3 23.3 43.7 51.2 13.1 3.9 0.4 18.8 36.7 48.9 23.8 14.9 8.8 6.9 19.9 5.6 30.2 5.7 6.9 15.2 29.4 4.8 5.6 20.6 5.9 20.9 16.9 7.4 7.1 8.9 9.7 12.0 13.0 8.5 10.9 13.9 10.3 13.4 11.6 9.3 15.1 59.2 3.2 19.6 75.4 97.3 28.4 23.3 27.6 63.2 17.3 26.9 21.0 18.3 14.3 19.2 31.3 29.2 7.1 50.1 17.8 15.6 19.3 28.1 40.1 36.2 46.4 17.5 50.7 99.5 11.9 9.6 22.2 29.0 40.4 12.0 25.9 35.7 17.3 77.4 18.5 98.9 20.0 8.2 105.3 198.9 13.9 26.1 104.2 26.6 152.7 93.7 20.4 22.6 101.0 98.3 17.4 10.7 28.6 69.9 24.0 15.7 23.6 25.3 19.6 19.7 28.5 32.3 33.0 21.3 72.1 38.2 4.4 38.3 21.2 16.6 18.0 REL "c-Rel, I-Rel" ENSG00000162924 "REL proto-oncogene, NF-kB subunit" Q04864 2 60881521-60931612 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins, RAS pathway related proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 37.4" "Cell type enhanced" "Detected in all" "Langerhans cells: 2061.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Daudi: 61.2;U-698: 109.7" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" CAB004404 Uncertain NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 41: Macrophages - Immune response" "CAB004404: AB_670194" "unprognostic (2.77e-1)" "unprognostic (2.05e-2)" "unprognostic (8.26e-2)" "unprognostic (1.20e-1)" "unprognostic (2.23e-1)" "unprognostic (4.41e-2)" "unprognostic (1.11e-1)" "unprognostic (7.15e-2)" "unprognostic (2.15e-1)" "unprognostic (5.87e-2)" "unprognostic (4.38e-2)" "unprognostic (4.37e-1)" "unprognostic (2.82e-2)" "unprognostic (2.91e-2)" "unprognostic (3.53e-1)" "unprognostic (3.85e-1)" "unprognostic (3.66e-2)" 4.8 4.5 2.2 14.1 1.8 37.4 5.5 8.6 4.2 4.6 0.4 4.6 4.7 5.7 2.7 6.0 3.2 8.2 2.2 2.1 2.9 3.4 7.3 6.7 15.8 3.0 1.7 5.0 5.0 6.2 1.9 5.5 2.3 4.1 4.9 9.8 4.6 2.7 2.4 8.3 5.2 3.5 0.5 11.1 5.8 3.5 2.4 9.2 4.1 2.5 16.3 13.1 3.3 3.4 7.2 3.8 3.4 4.5 2.7 2.6 7.3 2.5 3.2 1.8 2.1 3.2 6.0 61.2 6.4 2.2 4.6 7.7 5.3 3.9 4.0 7.0 5.0 6.3 6.5 3.5 1.5 13.3 7.1 2.3 10.1 4.6 7.0 3.0 4.8 6.6 7.6 4.3 1.7 4.0 9.1 5.6 4.2 5.0 1.8 12.0 8.8 2.7 2.8 24.5 3.3 3.5 6.4 7.9 2.3 5.0 4.6 5.5 5.6 5.0 6.0 3.5 3.8 5.4 2.8 109.7 3.0 10.9 2.7 3.4 4.1 2.6 2.8 4.5 2.0 5.9 1.5 2.2 3.5 7.9 1.0 2.1 5.0 2.9 5.7 3.1 1.9 2.3 2.2 1.8 8.6 4.2 2.1 2.9 3.0 1.7 2.3 0.5 2.4 3.4 67.5 320.5 325.8 8.1 430.2 517.6 123.3 69.4 194.6 82.0 95.3 58.5 5.0 48.6 165.0 51.5 85.5 29.0 469.7 59.0 3.9 31.7 4.2 150.5 79.5 103.5 42.5 37.0 16.3 29.4 58.5 97.3 96.4 300.1 412.1 82.4 30.0 19.1 51.7 58.9 16.7 49.1 46.8 141.5 2061.4 3.4 15.5 463.9 135.2 42.2 451.1 21.3 145.2 8.5 9.2 35.1 46.6 23.7 119.5 99.7 34.3 7.7 153.1 56.2 13.1 65.9 73.9 51.5 38.4 158.0 463.1 77.6 303.7 21.3 50.1 260.6 RET "CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51" ENSG00000165731 "Ret proto-oncogene" P07949 10 43077064-43130351 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Hirschsprung disease, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "adrenal gland: 20.8;brain: 27.3;parathyroid gland: 31.8" "Group enriched" "Detected in some" 4 "Horizontal cells: 79.1;Ionocytes: 26.4;Skeletal myocytes: 23.1" "Cancer enhanced" "Detected in many" "breast cancer: 11.0" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "MCF7: 74.6;NB-4: 42.2;SH-SY5Y: 329.3;THP-1: 95.9" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "midbrain: 53.3;spinal cord: 19.4" "CAB002581, HPA008356, HPA008495" Approved Supported Approved "Golgi apparatus,Plasma membrane,Cytosol" No NA 2100000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 50: Fibroblasts - ECM organization" "Golgi apparatus, Cytosol" "Plasma membrane" "CAB002581: AB_563673, HPA008356: AB_1847232, HPA008495: " "unprognostic (7.94e-2)" "unprognostic (3.68e-2)" "unprognostic (4.49e-1)" "prognostic unfavorable (5.02e-4)" "unprognostic (1.15e-1)" "unprognostic (9.13e-4)" "unprognostic (1.27e-2)" "unprognostic (3.62e-2)" "unprognostic (2.86e-1)" "unprognostic (2.01e-1)" "unprognostic (1.54e-3)" "unprognostic (4.43e-1)" "unprognostic (9.35e-5)" "unprognostic (1.64e-3)" "unprognostic (8.28e-2)" "unprognostic (3.67e-3)" "unprognostic (2.02e-2)" 1.8 20.8 1.0 1.3 0.9 0.4 1.1 5.1 5.6 1.0 0.2 3.4 1.4 0.6 0.3 0.4 0.5 0.6 2.2 0.3 5.5 0.9 3.0 0.4 0.6 14.4 27.3 0.4 1.3 31.8 5.3 0.5 12.0 1.8 1.4 4.7 5.1 2.0 5.9 0.9 1.4 1.0 4.8 0.2 2.2 2.7 7.6 1.6 0.8 3.1 0.2 0.6 1.4 5.8 0.1 0.4 0.1 1.7 0.0 0.0 0.1 0.7 0.2 0.4 0.1 0.0 0.0 0.0 0.1 0.0 0.6 0.0 5.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 7.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 74.6 0.0 42.2 7.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 4.7 329.3 0.1 0.0 0.1 0.5 4.1 95.9 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.9 0.7 0.1 0.0 1.0 0.9 5.1 5.6 0.3 5.5 14.4 27.3 12.0 4.8 7.6 5.8 0.4 0.0 0.5 1.6 0.0 0.3 0.8 0.0 0.0 1.7 6.0 0.5 2.1 0.0 0.0 0.0 0.0 0.0 2.1 0.2 0.0 0.0 1.5 0.0 0.3 1.1 0.0 0.0 4.2 0.2 2.3 6.8 0.0 0.0 1.3 0.5 0.0 1.2 0.1 79.1 8.6 1.9 26.4 0.0 0.6 1.5 0.3 0.5 0.0 1.0 0.0 0.8 0.0 1.0 0.6 0.0 0.0 0.0 0.0 0.9 0.0 0.1 0.8 1.7 0.0 23.1 1.2 1.1 4.7 0.0 0.6 0.0 0.2 0.3 0.2 0.1 ROS1 "c-ros-1, MCF3, ROS" ENSG00000047936 "ROS proto-oncogene 1, receptor tyrosine kinase" P08922 6 117287353-117425942 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 18 "epididymis: 58.6;lung: 31.7" "Cell type enriched" "Detected in some" 4 "Alveolar cells type 2: 78.5" "Cancer enriched" "Detected in some" 13 "lung cancer: 6.9" "Region enriched" "Detected in single" 4 "cerebral cortex: 2.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "GAMG: 19.3;HSkMC: 10.1;hTCEpi: 21.7;LHCN-M2: 14.9" "Not detected" "Not detected" "Not detected" "Not detected" "HPA049098, HPA072424" Uncertain Approved Vesicles NA NA "Cluster 30: Epididymis - Antimicrobial activity" "Cluster 30: Epithelial cell lines - Translation" "Cluster 11: Alveolar cells - Smell perception" Vesicles "HPA049098: AB_2680628, HPA072424: AB_2686519" "unprognostic (8.18e-2)" "unprognostic (4.64e-3)" "unprognostic (1.60e-1)" "unprognostic (2.37e-2)" "unprognostic (7.57e-2)" "unprognostic (2.05e-2)" "unprognostic (1.57e-1)" "unprognostic (1.79e-1)" "unprognostic (2.79e-2)" "unprognostic (1.00e-2)" "unprognostic (2.42e-1)" "unprognostic (5.20e-2)" "unprognostic (1.56e-12)" "unprognostic (1.09e-2)" "unprognostic (2.81e-1)" "unprognostic (1.91e-1)" "unprognostic (2.12e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.2 0.0 0.4 0.0 0.0 58.6 0.0 0.1 0.0 0.0 0.6 0.0 0.3 0.1 31.7 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.4 0.0 0.0 0.4 0.0 0.0 2.2 0.4 0.3 0.2 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.3 0.3 0.0 0.0 0.1 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 10.1 21.7 0.2 1.9 0.0 0.0 0.0 0.0 0.0 14.9 0.0 0.0 0.2 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 2.0 0.0 3.1 1.7 0.2 2.1 0.0 0.0 0.0 1.9 3.5 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 16.0 78.5 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.6 0.0 0.8 0.0 3.7 0.0 0.0 0.0 0.0 0.3 0.0 0.0 1.3 1.8 0.2 0.0 0.0 0.0 17.8 0.0 0.0 0.2 0.0 1.5 1.3 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 1.3 0.0 0.1 0.0 1.0 0.0 0.0 0.0 0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 RUNX1 "AML1, AMLCR1, CBFA2, PEBP2A2" ENSG00000159216 "RUNX family transcription factor 1" Q01196 21 34787801-36004667 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding, Repressor" "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Breast glandular cells: 175.5;Glandular and luminal cells: 155.8;Microglial cells: 195.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 23.9" "Lineage enriched" "Detected in all" 5 "granulocytes: 23.9" "Cell line enhanced" "Detected in many" "HEL: 251.3;HMC-1: 145.3;JURKAT: 226.3" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA004176, HPA037912" Enhanced Enhanced Nucleoplasm,Vesicles No No "Cluster 18: Basophils - Vesicular transport" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 35: Glandular cells - Unknown function" Nucleoplasm Vesicles "HPA004176: AB_1078412, HPA037912: AB_2675733" "unprognostic (4.06e-3)" "unprognostic (2.35e-2)" "unprognostic (1.42e-2)" "unprognostic (1.52e-1)" "unprognostic (5.15e-3)" "unprognostic (2.62e-1)" "unprognostic (5.87e-2)" "unprognostic (1.15e-1)" "unprognostic (1.13e-1)" "unprognostic (1.12e-3)" "unprognostic (2.33e-2)" "unprognostic (3.47e-2)" "prognostic unfavorable (3.44e-15)" "unprognostic (1.48e-1)" "unprognostic (1.50e-1)" "unprognostic (6.17e-2)" "unprognostic (5.47e-2)" 14.8 3.8 2.9 20.3 2.1 45.5 27.1 2.6 4.0 15.3 5.1 6.7 5.1 3.3 3.1 9.2 4.7 16.0 6.3 2.8 3.2 4.6 7.0 22.4 11.3 6.0 4.3 6.3 4.0 1.5 5.1 8.5 6.5 13.5 6.5 0.3 39.2 3.5 18.9 11.6 6.8 9.2 4.9 10.2 16.9 3.8 9.1 28.2 4.8 1.4 9.9 20.8 12.8 7.9 50.9 3.8 0.1 0.3 12.5 16.0 32.0 28.1 28.4 15.3 11.6 2.5 37.7 24.9 1.8 24.9 25.5 45.0 3.0 33.6 21.4 38.7 3.8 251.3 10.1 11.6 22.9 29.4 145.3 30.9 19.8 46.6 45.6 21.2 8.8 226.3 17.3 14.1 32.7 10.7 119.3 46.5 2.2 27.4 14.5 119.2 84.6 15.3 20.7 19.9 1.4 0.0 28.9 7.2 10.5 6.8 14.7 67.8 37.0 25.1 32.4 37.8 42.8 46.4 20.7 23.3 31.2 63.4 37.4 23.9 3.1 7.1 3.4 1.4 3.2 4.1 3.0 3.2 0.9 3.6 4.5 3.7 3.4 1.5 4.7 3.4 4.5 2.2 2.9 2.1 2.6 4.0 2.8 3.2 6.0 4.3 6.5 4.9 9.1 7.9 6.2 54.5 35.4 1.6 27.0 41.6 52.7 61.2 54.7 2.3 175.5 94.6 3.2 28.6 60.8 20.2 0.0 2.1 39.5 18.7 1.9 39.7 19.4 89.6 21.5 9.2 6.0 47.3 3.5 28.1 21.4 49.2 84.6 155.8 17.7 29.2 4.6 5.4 68.4 0.0 3.2 12.4 28.5 77.0 122.5 27.1 4.7 84.4 28.4 195.8 42.2 0.5 39.1 1.5 1.6 101.0 15.8 4.5 27.7 43.6 8.3 1.6 78.6 0.8 0.0 111.3 51.2 29.0 28.0 53.7 20.2 2.5 41.6 2.7 17.0 75.3 SDHB "SDH, SDH1" ENSG00000117118 "Succinate dehydrogenase complex iron sulfur subunit B" P21912 1 17018722-17054032 "Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Electron transport, Transport, Tricarboxylic acid cycle" Oxidoreductase "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 491.5;tongue: 580.6" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 405.5;Proximal tubular cells: 449.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002868, CAB009822, CAB068233, CAB068234, CAB068235" Enhanced Supported "Nucleoplasm,Plasma membrane,Mitochondria" "Intracellular and membrane" NA NA 7900 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "Nucleoplasm, Plasma membrane" "CAB009822: AB_2183458, CAB068233: AB_2665638, CAB068234: AB_2665639, CAB068235: AB_2665640, HPA002868: AB_1079889" "unprognostic (1.06e-1)" "unprognostic (2.86e-2)" "unprognostic (2.19e-2)" "unprognostic (2.93e-2)" "unprognostic (1.88e-1)" "unprognostic (2.79e-3)" "unprognostic (1.58e-1)" "unprognostic (3.02e-1)" "unprognostic (1.19e-1)" "unprognostic (8.45e-2)" "unprognostic (5.51e-2)" "unprognostic (3.93e-2)" "prognostic favorable (2.93e-7)" "unprognostic (1.46e-1)" "unprognostic (2.75e-1)" "unprognostic (7.82e-2)" "unprognostic (3.82e-2)" 85.8 95.7 68.0 59.0 72.2 94.6 68.7 80.6 84.3 56.8 81.1 134.3 163.0 56.0 71.0 77.4 59.8 48.0 302.8 69.9 76.9 228.0 336.1 56.1 75.3 74.8 71.4 44.4 80.3 144.3 42.8 57.6 73.8 55.7 132.4 62.9 74.0 60.5 491.5 55.6 121.9 70.4 73.9 60.5 92.8 64.4 74.9 62.7 64.3 580.6 84.2 71.3 52.0 78.9 157.3 152.7 72.2 107.8 141.6 135.2 95.9 122.4 145.2 254.3 227.7 216.8 183.1 206.8 159.3 156.4 176.1 180.1 290.7 226.8 284.8 128.7 280.6 183.4 149.2 168.2 172.8 276.0 135.6 140.4 154.9 224.5 370.1 138.7 183.6 176.5 165.2 236.9 179.6 129.5 182.4 175.1 70.4 224.6 302.6 146.1 142.5 265.4 252.4 88.7 157.5 86.0 172.3 216.3 392.3 76.4 131.1 169.1 94.9 115.8 131.0 206.4 176.0 98.9 133.3 198.6 170.4 438.5 128.3 68.7 149.8 149.5 71.4 206.5 70.7 89.9 81.0 77.5 186.8 81.1 73.5 74.8 174.3 85.3 185.7 89.3 113.8 116.1 68.0 72.2 80.6 84.3 69.9 76.9 74.8 71.4 73.8 73.9 74.9 78.9 48.2 64.1 47.4 20.9 57.4 52.1 93.3 199.8 40.5 31.5 45.2 49.4 405.5 101.5 97.0 47.8 14.6 107.1 48.3 176.1 354.1 134.3 220.3 48.7 38.2 54.7 48.6 77.3 27.7 149.2 142.2 62.0 46.9 45.5 66.6 39.9 46.8 226.0 177.4 37.0 32.1 103.1 116.0 88.7 67.9 30.5 57.8 78.4 64.0 29.0 123.1 78.3 48.4 15.6 24.6 111.5 218.3 67.7 62.2 74.4 300.5 449.0 79.8 53.8 39.5 57.1 191.6 148.9 71.5 72.9 54.6 121.8 46.8 69.3 162.0 110.9 SDHC "CYB560, cybL, PGL3" ENSG00000143252 "Succinate dehydrogenase complex subunit C" Q99643 1 161314381-161363206 "Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Electron transport, Transport, Tricarboxylic acid cycle" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal tubular cells: 776.7;Proximal tubular cells: 916.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 43: THP-1 - Innate immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "unprognostic (1.48e-2)" "unprognostic (6.88e-2)" "unprognostic (6.38e-3)" "unprognostic (1.86e-2)" "unprognostic (1.90e-2)" "unprognostic (5.02e-2)" "unprognostic (7.08e-2)" "unprognostic (2.33e-1)" "unprognostic (7.38e-2)" "unprognostic (1.35e-1)" "unprognostic (2.43e-2)" "unprognostic (1.29e-1)" "prognostic favorable (2.20e-4)" "unprognostic (9.14e-2)" "unprognostic (1.52e-1)" "unprognostic (4.19e-3)" "unprognostic (3.77e-1)" 128.9 143.7 73.7 64.1 79.7 60.5 100.3 84.5 85.1 78.7 92.9 118.9 127.8 70.9 76.0 109.7 98.6 63.3 154.1 68.4 83.4 285.7 319.4 65.5 74.7 78.8 79.1 69.2 62.5 173.6 52.4 73.1 76.7 77.3 132.2 84.3 74.8 84.7 277.4 69.8 101.4 101.4 85.1 62.8 89.9 52.7 84.8 93.1 89.5 288.4 105.1 88.4 61.3 85.6 161.1 129.7 157.5 147.7 248.3 213.3 196.3 150.9 190.3 180.3 137.3 185.4 208.7 53.7 190.6 214.8 121.6 178.5 244.3 214.2 193.2 185.6 205.6 110.2 106.6 196.7 126.9 193.8 109.1 211.5 181.7 174.3 119.4 167.9 177.5 164.0 178.9 43.8 266.3 167.0 152.4 112.5 145.4 376.3 123.7 131.6 151.0 217.1 330.3 167.8 118.3 180.7 211.0 385.1 225.4 207.9 342.1 259.3 133.5 103.7 125.1 127.9 147.3 173.3 287.8 269.4 140.3 139.2 193.6 88.6 111.0 65.7 76.6 99.6 79.6 68.6 66.2 75.4 136.1 65.7 71.2 71.0 52.0 66.9 87.5 100.6 78.3 130.0 73.7 79.7 84.5 85.1 68.4 83.4 78.8 79.1 76.7 85.1 84.8 85.6 50.9 44.8 59.4 14.7 70.1 61.8 151.2 342.6 59.7 74.9 81.4 58.3 94.0 131.5 163.5 150.8 64.6 248.0 65.5 95.9 776.7 218.4 18.6 87.1 63.8 80.7 66.8 81.4 19.3 145.2 248.5 79.8 79.5 62.6 58.3 66.6 83.2 249.1 237.3 72.3 27.4 103.4 215.7 100.6 74.4 34.7 102.9 94.6 129.9 9.4 176.1 107.8 107.1 17.6 24.5 142.7 89.5 109.1 71.9 100.2 139.1 916.5 177.9 69.3 52.6 74.5 94.4 115.3 114.4 111.2 76.4 307.6 72.0 215.7 154.2 155.0 SDHD "cybS, PGL, PGL1" ENSG00000204370 "Succinate dehydrogenase complex subunit D" O14521 11 112086824-112120016 "Cancer-related genes, Citric acid cycle related proteins, Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Electron transport, Transport, Tricarboxylic acid cycle" "Cancer-related genes, Disease variant, FDA approved drug targets, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal tubular cells: 530.2;Proximal tubular cells: 449.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045727 Approved "Intracellular and membrane" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 8: Non-specific - Mitochondria" "Cluster 1: K-562 - Erythropoiesis" "Cluster 39: Non-specific - Basic cellular processes" "HPA045727: AB_10963114" "unprognostic (9.13e-2)" "unprognostic (3.51e-2)" "unprognostic (4.47e-3)" "unprognostic (4.21e-2)" "unprognostic (1.93e-1)" "unprognostic (4.98e-2)" "unprognostic (5.69e-2)" "unprognostic (2.50e-1)" "unprognostic (1.83e-3)" "unprognostic (7.10e-2)" "unprognostic (3.03e-2)" "unprognostic (1.80e-1)" "prognostic favorable (1.99e-10)" "unprognostic (5.14e-2)" "unprognostic (1.58e-2)" "unprognostic (1.56e-2)" "unprognostic (7.51e-2)" 117.5 95.7 60.0 84.5 63.1 72.9 102.6 68.6 76.3 92.5 65.1 185.2 208.1 88.2 96.7 126.7 92.6 85.6 254.7 60.1 65.4 319.9 391.8 79.3 131.7 63.4 62.5 91.6 77.8 152.4 37.0 95.0 63.2 87.9 190.8 37.4 112.6 100.9 354.7 64.3 175.6 98.1 64.7 85.1 101.1 34.1 63.7 102.5 136.8 449.6 124.8 117.9 76.4 68.2 84.0 67.3 58.1 89.4 212.0 170.7 97.3 97.5 147.6 106.8 132.2 244.8 222.1 155.5 288.4 131.0 156.1 203.5 175.4 139.8 129.8 129.9 92.4 142.8 51.9 140.1 165.6 222.4 107.5 189.6 160.2 110.5 189.1 124.6 153.0 109.6 156.0 208.7 135.0 95.2 143.9 215.0 77.4 333.8 211.6 126.2 145.8 294.4 221.6 175.2 83.5 55.8 135.3 194.8 107.0 81.8 198.9 164.2 108.0 103.8 132.3 114.7 95.0 59.1 73.2 270.7 58.8 297.0 100.5 233.7 293.3 208.8 158.4 390.1 173.1 235.2 170.8 168.8 308.7 198.1 204.3 191.8 257.5 207.9 322.9 151.7 189.9 348.9 60.0 63.1 68.6 76.3 60.1 65.4 63.4 62.5 63.2 64.7 63.7 68.2 104.3 80.1 51.1 12.4 78.0 81.6 102.2 262.2 83.6 12.2 61.0 78.4 216.5 120.1 108.1 90.1 8.4 154.3 55.2 203.8 530.2 82.9 9.9 41.6 67.6 76.4 50.4 70.2 9.6 58.9 124.1 104.6 75.4 41.2 65.9 32.3 76.8 169.7 162.9 11.8 11.2 129.1 154.6 97.1 74.4 37.0 104.1 94.2 76.5 9.4 118.6 52.9 75.2 8.0 9.7 54.1 134.2 99.6 80.9 61.6 253.1 449.9 60.5 18.9 92.1 78.3 110.7 70.4 55.8 127.1 74.4 179.0 71.4 86.2 176.0 98.6 SETBP1 "KIAA0437, SEB" ENSG00000152217 "SET binding protein 1" Q9Y6X0 18 44680173-45068510 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" DNA-binding "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in many" 4 "Excitatory neurons: 349.0;Inhibitory neurons: 548.3;Oligodendrocyte precursor cells: 170.4" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in many" "cerebellum: 11.6" "Immune cell enhanced" "Detected in some" "naive B-cell: 3.0;plasmacytoid DC: 2.8" "Group enriched" "Detected in many" 5 "B-cells: 3.0;dendritic cells: 2.8;monocytes: 1.0" "Cell line enhanced" "Detected in many" "AF22: 16.1;Karpas-707: 44.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA049022, HPA057259" Uncertain Supported "Nucleoplasm,Nuclear bodies,Cytosol" NA NA 66000 "Cluster 19: B-cells - Humoral immune response" "Cluster 46: Fibroblasts - ECM organization" "Cluster 2: Karpas-707 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "Nuclear bodies, Cytosol" "HPA049022: AB_2680602, HPA057259: AB_2683384" "unprognostic (1.25e-1)" "unprognostic (1.57e-1)" "unprognostic (1.11e-1)" "unprognostic (1.97e-2)" "unprognostic (4.63e-2)" "unprognostic (1.80e-1)" "unprognostic (1.91e-1)" "unprognostic (3.57e-2)" "unprognostic (3.49e-1)" "unprognostic (2.01e-2)" "unprognostic (2.71e-3)" "unprognostic (6.52e-2)" "prognostic favorable (6.34e-8)" "unprognostic (2.18e-2)" "unprognostic (2.29e-1)" "unprognostic (6.06e-2)" "unprognostic (7.81e-5)" 7.3 1.9 2.0 3.7 3.7 1.8 6.3 11.6 5.7 11.6 0.0 10.9 1.7 8.3 7.2 4.5 7.2 5.0 4.3 2.6 0.2 7.4 4.7 6.6 5.3 0.0 0.1 7.7 5.8 3.7 2.7 7.2 0.1 7.8 3.5 3.0 4.3 9.2 10.7 4.4 4.6 7.4 0.0 3.7 5.6 1.8 0.0 4.4 5.1 9.7 4.7 8.1 8.5 3.8 0.0 2.4 16.1 0.0 4.1 1.2 1.0 1.3 3.0 1.5 1.3 0.2 0.0 1.0 0.5 1.8 1.0 4.8 1.8 4.9 1.0 1.4 0.8 0.0 1.8 1.2 0.0 0.0 0.0 3.8 2.0 0.0 3.0 2.7 0.5 0.0 0.1 44.7 0.4 0.8 0.0 0.1 2.0 0.0 1.1 5.6 0.0 5.5 4.9 3.9 8.2 4.2 0.0 0.0 0.9 7.1 2.2 0.0 0.0 9.5 3.3 0.0 7.7 8.6 0.5 0.0 5.8 0.2 5.5 0.1 0.0 0.0 0.4 0.6 0.0 2.0 0.0 0.2 0.0 3.0 0.0 0.1 0.0 0.0 1.0 2.8 0.0 0.1 2.0 3.7 11.6 5.7 2.6 0.2 0.0 0.1 0.1 0.0 0.0 3.8 7.6 0.0 1.8 85.5 42.4 15.4 8.6 8.3 7.4 12.5 11.0 12.6 3.9 14.3 4.2 16.5 18.8 1.5 25.5 1.6 3.9 4.5 1.3 12.9 15.6 8.3 12.0 0.8 349.0 3.5 1.4 29.3 4.1 14.8 0.0 0.7 17.9 16.5 2.0 3.3 548.3 4.4 10.2 2.4 8.7 3.7 62.7 4.6 3.6 88.1 1.5 10.7 6.2 170.4 62.9 3.7 9.1 39.9 29.6 8.1 0.4 10.5 5.8 18.2 6.6 18.4 28.6 0.3 0.8 4.0 15.2 0.8 5.9 0.1 4.7 1.5 SF3B1 "Hsh155, Prp10, PRPF10, SAP155, SF3b155" ENSG00000115524 "Splicing factor 3b subunit 1" O75533 2 197388515-197435079 "Cancer-related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "mRNA processing, mRNA splicing" RNA-binding "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA050275 Approved Enhanced "Nuclear speckles" NA NA 94000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 50: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" "Nuclear speckles" "HPA050275: AB_2681071" "unprognostic (6.86e-2)" "unprognostic (2.78e-1)" "unprognostic (2.14e-1)" "unprognostic (3.51e-1)" "unprognostic (4.42e-2)" "unprognostic (1.25e-3)" "unprognostic (2.44e-3)" "unprognostic (3.31e-3)" "unprognostic (1.25e-2)" "unprognostic (2.20e-1)" "unprognostic (6.79e-2)" "unprognostic (1.78e-2)" "unprognostic (2.57e-2)" "unprognostic (9.15e-2)" "unprognostic (1.16e-1)" "unprognostic (1.79e-1)" "unprognostic (3.41e-2)" 183.8 173.9 101.7 132.7 112.4 304.8 180.7 120.5 126.1 222.8 136.8 170.9 110.4 195.8 200.0 136.8 183.8 123.2 135.7 98.2 100.8 135.4 168.5 162.8 203.0 105.7 101.9 226.5 200.7 154.9 147.8 165.3 111.0 163.2 147.3 138.4 180.4 133.2 172.4 156.5 231.6 116.5 107.5 287.8 169.2 91.4 104.9 221.9 167.8 144.8 199.3 154.4 167.1 135.8 134.9 105.4 288.6 155.9 222.8 219.2 237.8 172.6 196.7 163.2 205.9 233.0 147.2 247.5 116.6 193.1 165.8 133.7 273.4 151.2 271.8 196.5 154.8 237.5 257.4 294.3 155.4 270.1 198.6 232.1 163.0 175.9 209.3 278.6 205.9 171.0 210.2 174.0 192.3 134.2 251.1 285.6 231.4 167.5 163.8 234.4 197.9 182.9 245.8 286.4 154.2 186.7 174.7 118.2 139.2 345.1 115.2 242.5 186.8 126.9 109.4 123.3 145.8 168.7 238.8 342.0 123.7 174.8 146.5 49.8 50.4 57.5 54.5 51.7 55.4 46.1 46.2 50.9 60.5 44.1 48.7 49.2 60.8 56.7 52.5 37.5 71.3 56.2 101.7 112.4 120.5 126.1 98.2 100.8 105.7 101.9 111.0 107.5 104.9 135.8 175.6 179.5 222.9 92.4 187.4 119.0 172.0 127.1 125.7 103.4 96.4 83.3 129.2 72.9 194.0 92.0 73.0 116.8 224.1 90.1 56.7 104.8 9.2 123.9 191.0 143.1 110.5 109.0 55.5 94.8 102.3 151.6 132.0 179.0 246.9 171.1 107.1 74.4 100.6 94.2 59.7 108.1 89.5 124.7 144.1 20.6 120.2 166.1 76.5 75.9 163.9 111.1 116.4 87.0 121.1 112.0 68.3 104.6 195.6 103.8 84.2 70.5 221.5 98.5 118.3 159.5 227.9 104.6 100.5 94.3 118.8 142.7 216.2 119.4 91.4 156.1 SHH "HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS" ENSG00000164690 "Sonic hedgehog signaling molecule" Q15465 7 155799980-155812463 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Developmental protein, Hydrolase, Protease" "Disease variant, Holoprosencephaly, Microphthalmia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 13.6;stomach 1: 10.5;urinary bladder: 16.2" "Cell type enhanced" "Detected in some" "Basal prostatic cells: 8.3;Cholangiocytes: 18.6;Collecting duct cells: 9.2;Gastric mucus-secreting cells: 9.7;Hepatocytes: 20.1;Intestinal goblet cells: 8.6;Pancreatic endocrine cells: 11.7;Urothelial cells: 8.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "EFO-21: 8.9;GAMG: 39.8;OE19: 10.2;RT4: 25.7" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "Intracellular and membrane" NA NA 5500000 "Cluster 85: Liver - Metabolism" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 22: Epithelial cell types - Mixed function" "unprognostic (7.17e-2)" "unprognostic (7.68e-3)" "unprognostic (6.70e-2)" "prognostic favorable (8.62e-5)" "unprognostic (1.59e-1)" "unprognostic (2.50e-2)" "unprognostic (2.39e-3)" "unprognostic (1.82e-2)" "unprognostic (1.83e-1)" "unprognostic (2.16e-2)" "unprognostic (3.47e-1)" "unprognostic (1.56e-1)" "unprognostic (1.77e-3)" "unprognostic (2.86e-1)" "unprognostic (2.85e-1)" "unprognostic (3.43e-2)" "unprognostic (2.66e-2)" 0.0 8.7 1.3 0.3 1.2 0.0 0.0 1.6 1.2 4.4 0.3 1.3 1.4 0.4 3.0 0.0 0.1 3.8 0.0 0.8 6.2 3.3 13.6 1.7 0.0 3.3 1.6 0.0 0.2 0.0 0.1 0.0 4.6 1.2 1.0 0.3 0.0 1.2 0.0 0.1 1.4 0.0 1.0 0.0 10.5 0.1 2.6 0.0 0.0 0.0 0.0 16.2 0.3 1.6 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 5.2 0.0 8.9 0.0 39.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 3.9 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.1 10.2 4.0 0.0 0.0 0.0 2.0 25.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 1.3 1.2 1.6 1.2 0.8 6.2 3.3 1.6 4.6 1.0 2.6 1.6 0.0 3.2 7.8 0.0 0.0 0.0 8.3 0.0 0.0 1.5 0.0 0.0 0.7 18.6 1.3 9.2 0.0 0.0 0.0 3.7 0.0 1.2 4.7 5.4 0.5 0.2 0.0 0.0 0.1 0.8 0.2 0.1 9.7 7.6 0.0 0.0 0.4 20.1 0.0 0.0 0.4 8.6 0.0 0.6 0.0 1.7 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 11.7 0.5 0.4 0.1 1.3 2.5 6.6 0.0 0.1 0.0 0.0 0.1 2.7 0.2 0.0 0.0 0.0 0.0 0.0 3.0 8.3 SMAD2 "JV18-1, MADH2, MADR2" ENSG00000175387 "SMAD family member 2" Q15796 18 47808957-47931146 "Cancer-related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors" "Transcription, Transcription regulation" DNA-binding "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025507, HPA067203, CAB073546" Approved Supported Nucleoplasm,Nucleoli,Cytosol NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 34: Non-specific - Transcription" "Cluster 20: HeLa - Mitochondria" "Cluster 9: Photoreceptor cells - Phototransduction" "Nucleoplasm, Nucleoli, Cytosol" "CAB025507: , CAB073546: , HPA067203: AB_2685803" "unprognostic (1.55e-1)" "unprognostic (2.49e-1)" "unprognostic (1.43e-2)" "unprognostic (9.82e-3)" "unprognostic (9.88e-2)" "unprognostic (1.06e-1)" "prognostic unfavorable (9.44e-5)" "unprognostic (1.91e-2)" "unprognostic (7.59e-2)" "unprognostic (1.41e-3)" "unprognostic (6.46e-2)" "unprognostic (4.91e-2)" "unprognostic (9.20e-3)" "unprognostic (2.68e-1)" "unprognostic (6.13e-2)" "unprognostic (3.20e-2)" "unprognostic (6.28e-2)" 48.6 52.6 38.0 38.6 42.4 37.5 46.5 46.2 36.7 43.2 35.6 47.5 36.7 38.6 41.0 55.0 46.8 39.6 53.8 32.9 48.6 43.3 35.6 46.7 44.5 50.2 43.2 52.5 40.4 44.6 20.3 42.7 51.9 36.4 48.7 70.5 36.7 44.8 57.4 34.0 37.4 47.9 47.8 47.5 45.2 51.5 42.4 72.4 75.7 55.5 55.2 53.8 31.1 59.4 81.1 113.7 68.0 66.2 106.1 128.5 77.4 86.1 102.7 87.9 101.8 43.8 75.6 124.8 60.3 110.0 123.0 86.6 77.2 96.1 116.9 136.4 39.3 106.4 164.4 71.9 123.2 149.6 104.1 95.8 121.4 75.5 172.9 102.1 98.6 99.7 50.3 101.6 109.6 52.7 103.4 71.6 33.6 4.4 26.7 74.4 98.9 85.9 197.8 137.2 62.8 73.3 103.7 70.1 85.7 65.8 53.5 97.7 111.4 129.5 74.2 35.6 63.6 99.0 102.7 108.3 89.6 99.9 97.1 58.8 33.6 38.7 23.8 38.5 29.8 16.7 32.3 29.9 32.8 13.9 35.3 27.6 34.1 38.6 33.0 23.3 40.5 31.6 38.0 42.4 46.2 36.7 32.9 48.6 50.2 43.2 51.9 47.8 42.4 59.4 55.0 44.8 36.1 55.8 36.3 54.4 44.1 38.3 54.1 48.0 44.2 30.2 49.2 41.5 45.5 77.3 212.7 48.2 53.0 42.8 39.2 36.5 68.1 58.6 53.0 53.1 51.0 36.4 63.4 43.5 40.3 40.5 44.4 68.1 21.5 80.0 56.4 29.6 43.9 35.3 50.5 46.1 38.7 57.3 41.8 131.9 41.7 48.7 51.6 104.9 63.9 44.8 72.1 96.0 130.0 44.0 31.6 53.4 34.5 66.1 37.9 39.5 41.8 88.1 32.9 53.5 39.6 37.2 39.4 59.2 61.8 69.5 47.4 41.7 42.3 77.2 SMAD4 "DPC4, MADH4" ENSG00000141646 "SMAD family member 4" Q13485 18 51028394-51085045 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" DNA-binding "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Granulosa cells: 132.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019154 Approved Supported Nucleoplasm,Centrosome,Cytosol NA NA "Cluster 35: T-regs - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 40: Granulosa cells - Unknown function" "Nucleoplasm, Cytosol" Centrosome "HPA019154: AB_1853480" "unprognostic (1.58e-1)" "unprognostic (1.75e-1)" "unprognostic (1.25e-2)" "unprognostic (4.83e-2)" "unprognostic (1.17e-2)" "unprognostic (4.05e-1)" "unprognostic (7.29e-3)" "unprognostic (9.00e-2)" "unprognostic (4.01e-2)" "unprognostic (2.51e-2)" "unprognostic (1.03e-3)" "unprognostic (4.40e-2)" "prognostic favorable (1.92e-5)" "unprognostic (2.62e-2)" "unprognostic (4.23e-1)" "unprognostic (1.36e-1)" "unprognostic (1.44e-1)" 16.4 11.8 9.0 10.9 10.3 10.6 17.2 21.7 10.5 18.5 11.2 14.9 11.9 20.6 9.8 15.7 16.3 12.8 14.1 11.7 10.0 16.1 19.1 13.1 12.7 9.0 8.2 24.0 21.4 19.9 11.3 18.9 9.4 21.8 14.3 18.3 14.0 18.0 24.9 14.6 12.1 18.9 8.0 13.9 15.2 14.2 11.9 17.7 21.4 24.9 14.5 13.5 13.1 13.8 16.4 22.5 59.4 16.6 23.9 36.6 31.4 27.7 32.2 39.4 49.6 13.0 3.8 25.9 7.8 25.6 19.6 24.9 33.6 13.2 40.7 19.3 14.8 20.6 20.5 15.9 23.7 34.8 13.1 16.6 21.9 19.1 27.8 37.0 28.7 14.0 21.9 25.8 23.5 9.0 18.8 10.0 31.2 9.1 14.3 23.3 30.6 26.9 18.2 7.4 34.4 20.3 27.0 5.0 18.8 24.8 13.3 19.4 20.0 34.5 13.3 8.8 19.7 30.6 28.6 26.2 21.2 12.8 22.6 0.3 0.6 0.6 1.0 0.4 1.1 0.7 1.0 0.8 1.2 0.9 1.2 1.5 1.0 1.0 0.4 1.0 1.4 0.5 9.0 10.3 21.7 10.5 11.7 10.0 9.0 8.2 9.4 8.0 11.9 13.8 32.5 22.4 29.1 55.2 21.0 25.6 20.9 15.1 18.8 17.1 27.3 20.4 38.8 24.3 19.3 22.0 20.9 20.7 24.0 22.7 11.7 16.9 10.6 30.4 36.6 26.2 39.6 12.4 37.0 12.5 20.6 30.3 28.5 35.2 4.5 132.4 28.5 44.1 15.1 15.2 39.0 32.1 16.2 28.5 20.9 16.2 33.2 21.1 28.4 49.6 16.9 20.4 17.5 41.2 72.5 20.1 21.0 30.5 24.8 36.3 26.7 22.6 22.4 20.0 26.3 32.2 34.2 17.2 18.8 20.9 27.3 12.6 20.1 22.1 24.5 29.7 SMARCB1 "BAF47, hSNFS, Ini1, PPP1R144, RDT, Sfh1p, SNF5, SNF5L1, Snr1" ENSG00000099956 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1" Q12824 22 23786931-23838009 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Host-virus interaction, Neurogenesis, Transcription, Transcription regulation" "Activator, Chromatin regulator, DNA-binding" "Cancer-related genes, Disease variant, Hypotrichosis, Mental retardation, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009196, HPA018248, HPA019127" Supported Supported "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 72: Non-specific - Transcription" "Cluster 12: NES - Nervous system development" "Cluster 57: B-cells - Immune response" Nucleoplasm "Nucleoli fibrillar center" "CAB009196: AB_2191983, HPA018248: AB_1851162, HPA019127: AB_1851165" "unprognostic (2.15e-1)" "unprognostic (5.62e-2)" "unprognostic (6.60e-3)" "unprognostic (1.63e-2)" "unprognostic (4.01e-3)" "unprognostic (2.14e-1)" "prognostic unfavorable (6.52e-4)" "unprognostic (4.10e-1)" "unprognostic (1.86e-1)" "unprognostic (1.03e-2)" "unprognostic (2.10e-2)" "unprognostic (4.43e-3)" "prognostic favorable (1.14e-6)" "unprognostic (1.24e-1)" "unprognostic (4.58e-2)" "unprognostic (4.57e-2)" "unprognostic (7.04e-2)" 35.9 46.4 2.3 6.9 2.5 3.3 40.3 4.1 10.0 51.5 2.7 40.9 8.1 51.4 0.4 51.0 40.4 2.2 44.0 2.3 2.3 47.0 36.9 32.3 5.8 4.3 2.7 63.1 43.9 1.2 48.0 1.2 2.7 36.6 1.1 25.3 44.1 0.6 48.1 50.1 51.7 0.6 2.2 51.7 40.4 68.3 2.3 3.5 41.3 1.8 1.5 37.5 40.9 2.9 2.4 1.6 28.2 2.6 2.7 0.7 5.8 9.2 2.7 2.7 4.3 3.4 2.6 24.2 7.9 1.2 2.9 4.4 6.9 4.6 4.5 4.1 10.5 20.1 3.2 2.1 3.0 21.7 5.6 1.6 3.4 3.2 6.9 1.4 1.4 3.0 5.6 12.9 1.7 6.1 17.6 5.0 8.6 7.2 5.7 11.0 23.1 10.8 2.3 4.5 13.4 10.1 2.2 0.6 17.9 14.8 2.2 3.3 2.2 2.4 9.8 3.8 2.7 13.8 14.3 17.7 1.8 11.3 6.8 7.1 12.8 6.4 4.4 13.4 6.4 24.4 5.5 5.7 12.0 9.2 4.5 3.0 1.1 9.8 16.8 13.3 10.4 8.1 2.3 2.5 4.1 10.0 2.3 2.3 4.3 2.7 2.7 2.2 2.3 2.9 33.6 6.4 8.6 17.0 120.2 50.2 73.3 85.1 51.2 55.4 42.9 49.1 6.1 47.1 37.4 47.8 20.9 120.6 61.8 36.6 84.1 94.6 42.6 40.9 54.9 37.4 71.8 57.8 14.1 77.1 228.1 46.2 41.8 41.1 34.8 112.2 41.0 20.3 76.1 67.3 18.4 54.6 99.7 23.0 41.7 18.9 35.8 36.5 56.9 15.9 51.2 92.4 45.3 17.1 18.1 74.7 53.1 32.0 139.6 74.4 41.9 86.4 28.5 49.6 19.7 47.7 62.8 138.9 163.3 64.5 53.0 160.1 42.0 96.8 65.4 65.1 SMARCE1 BAF57 ENSG00000073584 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1" Q969G3 17 40624962-40648654 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors" Neurogenesis "Chromatin regulator, DNA-binding" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003916, CAB037318" Supported Supported Nucleoplasm NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 34: Non-specific - Transcription" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 59: Non-specific - Transcription" Nucleoplasm "CAB037318: AB_476780, HPA003916: AB_1857279" "unprognostic (7.91e-2)" "unprognostic (2.68e-2)" "unprognostic (2.09e-2)" "unprognostic (8.06e-3)" "unprognostic (1.87e-1)" "unprognostic (2.55e-2)" "unprognostic (4.48e-1)" "unprognostic (1.25e-2)" "unprognostic (2.20e-2)" "unprognostic (1.05e-1)" "unprognostic (2.53e-2)" "unprognostic (2.04e-1)" "unprognostic (9.80e-2)" "unprognostic (5.93e-2)" "unprognostic (7.63e-2)" "unprognostic (1.09e-1)" "unprognostic (1.27e-2)" 39.4 22.2 10.5 37.8 11.9 43.2 35.6 10.6 13.3 45.9 14.3 40.2 38.9 56.2 28.3 43.6 39.0 41.4 40.1 9.2 11.7 31.2 31.5 36.1 49.6 13.7 10.7 58.6 35.4 38.3 13.3 48.4 13.2 34.2 38.5 17.5 33.6 42.1 42.5 27.7 39.3 57.4 11.7 40.5 30.9 31.5 11.2 76.1 40.8 44.7 54.2 46.8 26.2 16.5 86.5 139.6 169.1 126.5 87.7 125.5 82.8 105.9 145.4 122.1 91.0 92.7 72.7 135.9 149.6 145.3 81.0 114.5 106.1 112.3 145.1 128.3 138.0 97.2 73.4 165.2 87.8 179.8 94.5 109.3 87.6 97.7 140.6 122.1 133.4 106.5 144.2 52.2 118.2 96.5 331.6 37.1 95.4 70.8 68.6 183.3 190.2 103.7 147.5 144.9 134.6 130.0 94.5 269.4 86.6 181.5 161.5 111.4 109.7 98.1 107.6 89.7 132.6 97.7 122.8 204.5 100.0 80.9 154.9 106.3 64.4 88.2 91.7 67.8 95.0 99.8 82.4 96.1 77.9 112.3 68.3 79.3 26.5 124.7 82.2 80.3 114.7 112.2 10.5 11.9 10.6 13.3 9.2 11.7 13.7 10.7 13.2 11.7 11.2 16.5 41.4 48.1 45.1 13.1 67.5 38.1 43.0 69.5 65.4 75.8 19.7 20.2 53.0 38.6 61.5 20.2 16.7 101.8 68.7 38.7 15.6 41.5 27.1 34.9 47.0 60.4 96.5 84.1 17.1 32.3 75.7 72.4 44.9 32.1 74.0 41.3 62.8 44.0 51.6 82.4 18.8 53.5 65.1 42.9 39.6 11.8 90.4 30.9 24.9 19.7 63.2 63.3 105.0 26.7 32.7 35.7 46.7 82.4 44.2 36.5 52.8 30.5 59.3 37.1 39.5 62.7 57.0 49.7 50.9 63.3 40.1 114.8 53.8 35.3 62.5 34.3 SMO "FZD11, SMOH" ENSG00000128602 "Smoothened, frizzled class receptor" Q99835 7 129188633-129213545 "Cancer-related genes, Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Plasma proteins, Predicted membrane proteins, Transporters" "Developmental protein, G-protein coupled receptor, Receptor, Transducer" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 27.4;Granulosa cells: 13.0;Leydig cells: 20.8;Muller glia cells: 16.6;Peritubular cells: 21.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 45.3;AN3-CA: 84.9;NTERA-2: 64.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB011446 Approved NA NA "Cluster 15: Liver - Metabolism" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 36: Stromal cells - Cell proliferation" "CAB011446: " "unprognostic (2.48e-2)" "unprognostic (2.69e-2)" "unprognostic (7.09e-2)" "unprognostic (1.10e-1)" "unprognostic (8.16e-2)" "unprognostic (2.02e-1)" "unprognostic (3.63e-1)" "unprognostic (5.89e-2)" "unprognostic (5.38e-3)" "unprognostic (1.59e-1)" "unprognostic (1.17e-2)" "unprognostic (8.74e-3)" "unprognostic (1.62e-1)" "unprognostic (5.15e-3)" "unprognostic (2.09e-1)" "unprognostic (2.25e-1)" "unprognostic (2.61e-2)" 5.2 6.0 9.4 2.6 10.8 0.4 5.5 9.9 9.6 27.4 18.4 9.6 2.5 19.2 18.6 12.0 14.5 8.4 8.0 8.9 10.0 19.0 23.9 3.6 2.2 12.4 12.4 28.3 6.3 16.1 19.2 2.6 9.9 20.0 2.1 2.0 11.5 12.3 3.7 17.1 5.7 8.1 11.8 2.8 6.3 5.6 11.4 4.4 9.1 3.7 2.0 9.0 16.7 9.7 1.6 18.2 45.3 84.9 1.1 0.2 14.3 5.2 6.7 10.1 5.8 13.8 0.1 0.0 13.9 10.4 22.8 28.3 27.4 1.5 3.9 0.0 23.0 9.4 0.0 22.5 5.5 0.4 0.0 16.2 11.0 3.3 0.0 19.9 5.8 24.9 1.5 0.0 3.1 0.0 24.4 0.1 64.2 0.0 5.3 35.1 19.7 0.0 5.2 0.0 1.3 30.2 0.0 0.0 12.3 16.8 11.1 5.8 0.0 0.7 14.1 17.6 10.1 0.6 0.0 0.0 0.0 0.0 16.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.4 10.8 9.9 9.6 8.9 10.0 12.4 12.4 9.9 11.8 11.4 9.7 0.4 0.0 0.0 27.4 0.2 1.9 2.3 3.9 2.8 0.7 3.3 5.2 1.4 2.8 3.8 11.0 0.0 0.3 0.4 0.0 1.9 3.4 0.4 1.0 8.6 0.6 0.0 0.0 1.4 1.1 0.3 7.6 0.0 1.3 0.0 13.0 1.4 8.4 4.2 0.0 0.8 0.1 2.0 1.6 1.8 1.3 20.8 1.0 0.0 3.7 0.6 16.6 0.0 4.5 0.5 1.3 0.1 21.8 0.0 2.7 0.0 3.9 0.7 0.4 6.6 3.5 3.9 0.0 2.0 3.3 2.8 0.5 0.1 6.9 0.6 0.7 SPI1 "OF, PU.1, SFPI1, SPI-1, SPI-A" ENSG00000066336 "Spi-1 proto-oncogene" P17947 11 47354860-47378547 "Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding, RNA-binding" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 6 "bone marrow: 335.1;lung: 101.0;lymphoid tissue: 172.7" "Group enriched" "Detected in many" 6 "Hofbauer cells: 432.9;Kupffer cells: 411.9;Langerhans cells: 537.6;Macrophages: 453.3;monocytes: 357.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 179.7" "Lineage enriched" "Detected in many" 5 "granulocytes: 179.7" "Cell line enhanced" "Detected in some" "HEL: 90.1;HL-60: 159.7;HMC-1: 282.2;NB-4: 267.8;THP-1: 206.7;U-698: 85.3;U-937: 117.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004079, HPA044653" Enhanced Supported Nucleoplasm NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 4: Macrophages - Innate immune response" Nucleoplasm "CAB004079: AB_10692379, HPA044653: AB_2679036" "unprognostic (4.45e-2)" "unprognostic (3.31e-3)" "unprognostic (2.92e-2)" "unprognostic (1.66e-2)" "unprognostic (5.97e-2)" "unprognostic (3.33e-2)" "unprognostic (5.28e-2)" "unprognostic (1.07e-1)" "unprognostic (2.35e-2)" "unprognostic (2.79e-1)" "unprognostic (3.36e-1)" "unprognostic (1.78e-1)" "prognostic unfavorable (2.07e-5)" "unprognostic (1.20e-1)" "unprognostic (4.95e-2)" "unprognostic (2.40e-1)" "unprognostic (4.92e-2)" 36.5 19.7 12.0 107.3 13.1 335.1 17.7 14.3 19.4 7.9 15.8 15.6 21.5 7.3 2.1 9.1 19.1 21.3 13.5 11.7 16.4 10.6 15.6 101.0 65.0 31.2 20.9 5.2 7.8 3.1 7.6 28.0 24.7 10.3 10.2 1.0 14.6 6.1 5.0 13.8 29.3 21.9 19.8 172.7 17.0 3.7 26.2 15.7 8.8 8.3 32.0 29.9 7.6 30.3 0.2 0.0 0.0 0.0 0.0 0.1 0.5 0.1 0.0 0.2 0.1 0.0 0.0 72.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 90.1 0.0 0.0 0.0 159.7 282.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 11.7 0.7 0.0 0.0 0.2 267.8 0.2 0.0 0.0 48.7 0.2 47.5 0.0 0.0 0.2 0.3 0.0 0.0 0.6 0.0 0.0 206.7 0.3 0.0 0.5 0.5 0.1 0.1 0.3 85.3 0.3 117.5 0.1 14.1 19.2 179.7 0.0 27.4 0.0 3.9 0.0 0.0 16.4 2.4 0.0 0.0 83.8 0.0 34.7 0.9 0.0 7.3 12.0 13.1 14.3 19.4 11.7 16.4 31.2 20.9 24.7 19.8 26.2 30.3 2.1 3.2 1.1 10.4 72.6 10.5 0.5 0.0 1.2 1.3 2.1 5.0 2.9 4.3 0.6 5.5 0.0 2.3 6.3 0.5 19.6 0.1 7.5 0.1 0.3 5.5 4.2 39.7 3.1 0.4 3.1 2.6 1.1 0.3 33.7 0.2 7.9 3.2 432.9 0.0 3.3 0.3 0.0 411.9 537.6 27.5 1.8 453.3 10.6 36.5 357.5 7.0 8.2 3.5 1.5 0.0 0.1 0.0 21.8 0.4 0.2 2.3 0.7 1.7 13.1 1.5 1.4 5.1 9.3 0.8 9.9 4.2 4.8 1.1 0.4 0.5 SRSF2 "PR264, SC-35, SC35, SFRS2, SFRS2A" ENSG00000161547 "Serine and arginine rich splicing factor 2" Q01130 17 76734115-76737333 "Cancer-related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "mRNA processing, mRNA splicing" RNA-binding "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049905 Supported Approved Nucleoplasm,Cytosol NA NA 180000 "Cluster 39: Non-specific - mRNA processing" "Cluster 18: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm Cytosol "HPA049905: AB_2680945" "unprognostic (2.50e-1)" "unprognostic (2.16e-3)" "unprognostic (2.73e-3)" "prognostic unfavorable (8.73e-4)" "unprognostic (1.75e-2)" "unprognostic (4.19e-2)" "prognostic unfavorable (3.53e-8)" "unprognostic (1.19e-1)" "unprognostic (7.79e-3)" "unprognostic (7.03e-3)" "unprognostic (1.92e-1)" "unprognostic (1.07e-3)" "prognostic unfavorable (1.05e-7)" "unprognostic (3.85e-2)" "unprognostic (8.05e-2)" "unprognostic (1.95e-1)" "prognostic favorable (9.87e-4)" 106.0 106.8 27.8 95.5 29.6 184.7 92.1 29.9 34.0 83.6 37.7 100.3 86.2 88.9 64.0 129.5 89.5 42.1 78.5 29.2 32.9 83.0 115.2 95.4 111.6 30.8 28.5 85.6 88.3 48.4 81.9 66.0 30.3 78.0 71.6 53.4 90.6 52.3 91.7 96.5 113.2 49.0 31.3 121.6 94.4 49.5 30.0 94.2 102.1 36.0 100.2 80.0 94.3 36.0 318.7 239.8 289.5 207.5 70.9 58.5 300.5 197.3 146.8 225.4 207.0 257.2 216.8 478.0 143.3 188.7 164.3 279.9 293.3 229.0 230.2 202.3 489.3 357.9 246.6 311.9 79.3 404.4 210.6 65.2 51.1 186.2 54.0 91.1 179.9 212.0 373.4 209.6 183.7 251.0 460.0 440.9 339.5 186.4 340.2 455.0 310.6 360.5 156.5 225.2 247.7 350.8 227.1 196.3 120.4 154.0 238.8 301.6 187.9 206.9 271.3 139.4 330.0 278.2 219.2 552.9 187.3 318.9 177.1 2.5 40.9 10.0 26.0 53.3 26.0 23.5 17.7 26.7 67.0 19.6 20.1 19.4 4.4 35.6 33.6 49.2 24.0 33.0 27.8 29.6 29.9 34.0 29.2 32.9 30.8 28.5 30.3 31.3 30.0 36.0 271.3 118.6 105.6 57.5 396.7 460.8 439.7 205.9 540.1 151.9 291.7 277.9 86.2 148.7 141.5 88.3 91.8 339.4 548.0 233.1 156.5 199.1 203.6 176.8 181.9 204.3 266.3 366.6 51.1 157.3 579.7 233.9 196.7 257.4 218.4 241.7 116.7 125.1 251.3 99.3 55.4 246.9 132.2 143.7 480.4 162.0 159.1 273.5 282.8 63.7 226.9 153.3 196.7 55.8 87.9 189.0 288.7 127.5 492.0 384.8 250.5 128.7 97.4 188.9 118.3 286.8 242.1 272.3 296.8 489.5 443.4 316.0 469.1 185.4 329.4 459.4 SSX1 CT5.1 ENSG00000126752 "SSX family member 1" Q16384 X 48255392-48267444 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Transcription, Transcription regulation" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 17 "testis: 6.8" "Group enriched" "Detected in some" 4 "Spermatocytes: 24.2;Spermatogonia: 30.2" "Cancer enhanced" "Detected in many" "liver cancer: 7.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 12 "Daudi: 66.1;Karpas-707: 90.5;U-2197: 22.7" "HPA045683, HPA071685" Supported Approved Nucleoplasm,Nucleoli NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 2: Karpas-707 - Immune response" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "Nucleoplasm, Nucleoli" "HPA045683: AB_2679418, HPA071685: " "unprognostic (2.25e-1)" "unprognostic (3.51e-3)" "unprognostic (2.36e-1)" "unprognostic (4.32e-3)" "unprognostic (3.38e-1)" "unprognostic (5.41e-2)" "unprognostic (6.94e-2)" 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 6.8 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 66.1 0.1 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 90.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.3 0.0 0.1 0.0 0.2 22.7 0.1 0.0 4.8 0.1 5.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.6 0.0 0.0 24.2 30.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SSX2 "CT5.2a, HD21, HOM-MEL-40, MGC119055, MGC15364, MGC3884, SSX" ENSG00000241476 "SSX family member 2" Q16385 X 52696896-52707189 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Transcription, Transcription regulation" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 59 "testis: 15.0" "Cell type enriched" "Detected in single" 4 "Spermatogonia: 2.9" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA045683, HPA071685" Enhanced Approved Nucleoplasm,Nucleoli NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" "Nucleoplasm, Nucleoli" "HPA045683: AB_2679418, HPA071685: " 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 STAT3 APRF ENSG00000168610 "Signal transducer and activator of transcription 3" P40763 17 42313324-42388540 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Host-virus interaction, Transcription, Transcription regulation" "Activator, DNA-binding" "Cancer-related genes, Diabetes mellitus, Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001671, CAB003859, HPA058603, CAB068241, CAB068242" Supported Supported Nucleoplasm,Cytosol NA NA 55000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 46: Photoreceptor cells - Phototransduction" "Nucleoplasm, Cytosol" "CAB003859: AB_347629, CAB068241: AB_2665663, CAB068242: AB_2665662, HPA001671: AB_1080102, HPA058603: AB_2683772" "unprognostic (1.83e-2)" "unprognostic (2.42e-1)" "unprognostic (9.23e-3)" "unprognostic (2.91e-1)" "unprognostic (5.59e-3)" "unprognostic (1.78e-2)" "unprognostic (8.26e-2)" "unprognostic (1.51e-1)" "unprognostic (1.32e-1)" "unprognostic (1.77e-1)" "unprognostic (2.21e-1)" "unprognostic (1.26e-1)" "unprognostic (6.47e-3)" "unprognostic (7.75e-3)" "unprognostic (2.21e-2)" "unprognostic (7.63e-2)" "unprognostic (1.61e-1)" 105.6 68.1 32.4 78.5 34.5 63.2 84.4 38.7 30.2 62.6 32.4 76.9 45.9 71.6 28.2 81.6 74.0 71.7 101.2 28.6 44.6 77.2 143.1 106.0 55.3 48.4 40.7 65.4 67.3 35.3 53.3 55.6 43.4 62.9 46.5 29.9 63.5 48.2 123.9 66.8 68.1 72.1 43.9 68.0 62.3 24.6 43.0 50.5 61.9 92.1 65.2 88.6 64.3 43.1 61.5 116.0 47.4 48.2 103.7 97.6 35.4 66.5 89.7 59.6 58.3 30.3 55.8 18.5 68.2 71.2 90.3 89.2 45.8 72.6 47.7 160.6 31.4 131.2 60.4 62.4 77.3 31.8 79.0 152.1 69.8 47.4 68.9 62.2 81.1 33.4 80.1 56.4 40.1 43.8 118.7 31.3 28.5 63.4 0.0 26.6 133.8 28.1 91.3 77.2 45.2 29.8 81.4 184.9 29.2 57.2 100.5 49.1 68.7 88.9 44.9 54.8 56.5 82.9 75.3 16.4 56.1 32.8 41.6 121.1 78.4 100.0 79.5 79.9 64.4 40.2 57.5 62.6 54.3 36.6 58.7 56.5 262.6 58.3 80.8 29.3 47.9 124.5 32.4 34.5 38.7 30.2 28.6 44.6 48.4 40.7 43.4 43.9 43.0 43.1 216.0 93.0 173.7 46.0 111.6 129.5 105.3 76.8 138.3 92.6 147.1 113.0 59.7 54.3 103.2 134.3 281.5 25.2 115.1 148.9 17.6 83.2 33.5 129.3 187.0 164.7 124.0 54.3 24.2 96.8 38.2 154.0 109.1 153.9 142.0 86.3 115.3 115.7 69.1 25.2 35.8 97.8 69.2 71.0 121.7 13.7 71.7 111.7 72.9 51.5 94.1 131.3 78.2 30.7 41.7 82.9 94.5 60.9 104.6 147.9 206.4 46.3 88.5 406.7 65.7 189.5 169.7 31.5 15.3 93.4 160.1 31.2 170.2 102.3 117.5 90.6 STK11 "LKB1, PJS" ENSG00000118046 "Serine/threonine kinase 11" Q15831 19 1177558-1228431 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Autophagy, Cell cycle, Differentiation, DNA damage, Spermatogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 154.9;Late spermatids: 338.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 9.9" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB016231, HPA017254, CAB022105, HPA067481" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 59: Non-specific - Translation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 31: Spermatids - Spermatogenesis" Nucleoplasm Cytosol "CAB016231: AB_627890, CAB022105: , HPA017254: AB_1852924, HPA067481: AB_2685847" "unprognostic (8.60e-2)" "unprognostic (1.68e-1)" "unprognostic (5.00e-2)" "prognostic favorable (3.69e-5)" "unprognostic (2.04e-2)" "prognostic favorable (1.96e-4)" "unprognostic (9.11e-3)" "unprognostic (3.19e-1)" "unprognostic (9.08e-2)" "unprognostic (1.26e-1)" "unprognostic (1.95e-3)" "unprognostic (7.70e-3)" "unprognostic (3.54e-2)" "unprognostic (3.16e-2)" "unprognostic (1.60e-1)" "unprognostic (3.31e-1)" "unprognostic (3.12e-3)" 32.1 44.2 18.8 18.2 15.5 34.1 32.3 24.8 23.5 35.4 24.7 38.7 25.6 33.6 5.5 39.7 34.9 11.8 48.4 18.3 14.7 36.4 45.5 30.5 20.5 19.2 19.4 37.9 34.2 16.1 36.8 12.6 15.2 39.3 7.7 5.7 29.7 16.1 108.2 40.2 37.7 9.6 16.3 48.3 38.1 102.4 17.6 15.0 34.3 27.7 12.9 34.4 35.0 14.9 50.0 25.8 19.9 35.9 18.6 17.0 35.5 24.0 27.7 25.1 25.4 22.5 37.1 31.9 24.8 27.8 11.2 32.3 20.1 41.9 8.2 60.2 37.8 34.8 1.7 26.4 38.1 36.6 53.5 30.5 28.9 19.4 29.2 22.3 25.2 28.1 63.1 51.1 13.9 39.3 31.9 27.7 33.0 19.6 25.1 50.0 20.0 36.1 21.1 39.7 39.8 26.6 0.0 19.7 24.2 11.4 30.3 55.2 33.7 24.6 25.0 45.2 38.7 85.3 38.1 25.7 22.6 48.1 25.5 1.7 3.3 3.9 0.4 5.5 0.3 2.3 0.8 1.4 1.6 0.7 0.7 0.6 9.9 1.4 5.7 0.8 0.6 0.5 18.8 15.5 24.8 23.5 18.3 14.7 19.2 19.4 15.2 16.3 17.6 14.9 24.5 6.4 13.7 12.7 10.5 16.7 7.4 9.5 9.6 25.5 22.0 18.4 13.7 15.7 9.0 23.9 18.8 7.5 20.1 44.4 7.9 9.4 154.9 18.0 18.1 15.7 15.0 27.3 7.9 14.0 5.3 13.2 21.9 17.8 2.5 80.3 15.4 31.6 15.2 18.5 8.5 33.1 6.1 18.3 26.4 338.7 24.5 20.7 16.0 11.2 20.4 21.2 9.2 9.0 6.5 16.7 29.3 20.7 10.2 15.1 27.5 11.0 9.3 21.0 13.1 21.5 23.7 85.5 20.1 14.6 15.5 8.8 16.6 45.2 35.4 12.6 SUFU "PRO1280, SUFUH, SUFUXL" ENSG00000107882 "SUFU negative regulator of hedgehog signaling" Q9UMX1 10 102503972-102633535 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Developmental protein" "Cancer-related genes, Ciliopathy, Disease variant, Joubert syndrome, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 129.2;Late spermatids: 115.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008700 Supported Supported Nucleoplasm NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 27: Brain & Skin - Unknown function" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 34: Spermatids - Unknown function" Nucleoplasm "HPA008700: AB_1080125" "unprognostic (1.55e-1)" "unprognostic (4.00e-2)" "unprognostic (5.14e-2)" "unprognostic (1.33e-1)" "unprognostic (4.69e-2)" "unprognostic (5.68e-2)" "unprognostic (3.69e-2)" "unprognostic (5.99e-2)" "unprognostic (1.64e-1)" "unprognostic (3.15e-3)" "unprognostic (9.60e-2)" "unprognostic (2.13e-1)" "unprognostic (3.72e-3)" "unprognostic (1.82e-1)" "unprognostic (1.44e-1)" "unprognostic (5.10e-2)" "unprognostic (3.82e-3)" 6.6 7.2 8.8 7.1 8.5 2.0 6.1 8.9 8.0 8.6 5.5 6.8 3.9 7.4 4.9 9.2 7.1 6.6 6.3 7.8 7.3 6.1 6.2 5.8 7.2 8.3 8.2 8.9 4.1 11.1 4.3 7.4 7.8 8.5 4.4 4.6 7.1 5.2 8.6 14.4 5.7 7.3 6.7 7.4 4.6 11.5 8.0 7.8 3.4 7.3 8.1 8.8 9.2 7.3 8.7 9.1 14.4 20.8 14.5 12.1 7.0 8.8 17.0 12.5 11.3 8.5 6.3 8.9 24.5 9.9 5.0 6.0 17.8 9.8 8.2 5.5 13.8 21.2 5.2 8.0 6.9 7.7 14.6 13.9 7.5 9.3 7.5 22.9 16.3 8.5 4.8 7.9 7.8 7.2 14.8 11.6 4.1 5.6 6.7 15.8 15.5 4.7 8.3 12.8 4.8 7.8 7.0 6.4 8.1 13.1 14.2 5.0 18.1 5.5 7.8 6.0 9.8 6.4 4.5 6.4 6.9 14.9 3.8 2.0 2.0 2.9 1.0 2.4 0.8 0.9 1.2 1.1 1.9 0.8 0.8 1.0 0.4 1.1 2.5 1.1 0.8 1.4 8.8 8.5 8.9 8.0 7.8 7.3 8.3 8.2 7.8 6.7 8.0 7.3 3.3 0.0 3.7 28.7 4.9 3.1 2.1 2.9 6.8 4.2 3.5 3.0 4.0 1.5 4.6 3.7 8.4 7.8 3.1 3.5 1.9 4.4 129.2 4.5 6.2 5.1 1.2 2.5 25.9 3.0 3.5 6.0 4.6 8.5 3.8 3.8 10.8 5.4 12.4 1.7 22.2 2.2 0.0 9.4 6.3 115.9 5.0 8.7 0.0 32.8 7.8 2.7 4.1 17.6 16.8 4.1 1.3 6.8 4.0 2.0 5.7 5.8 5.7 4.8 0.0 3.0 4.5 8.7 5.3 8.9 6.5 7.0 7.1 7.6 3.0 1.3 TAL1 "bHLHa17, SCL, TCL5" ENSG00000162367 "TAL bHLH transcription factor 1, erythroid differentiation factor" P17542 1 47216290-47232220 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Differentiation, Transcription, Transcription regulation" "Developmental protein, DNA-binding" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 29.4" "Cell type enriched" "Detected in some" 4 "Erythroid cells: 151.5" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HEL: 153.7;HMC-1: 70.6;HUVEC TERT2: 31.2;JURKAT: 60.0;K-562: 48.9;MOLT-4: 26.3;TIME: 34.4" "Region enriched" "Detected in many" 5 "midbrain: 14.3" "Low region specificity" "Detected in many" "CAB017805, HPA047866, HPA073983" Approved Enhanced Nucleoplasm Yes NA "Cluster 10: Basophils - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 36: HEL - Hemostasis" "Cluster 6: Erythroid cells - Oxygen transport" Nucleoplasm "CAB017805: , HPA047866: AB_2680192, HPA073983: AB_2732246" "unprognostic (2.63e-1)" "unprognostic (2.62e-2)" "unprognostic (1.22e-1)" "unprognostic (2.40e-2)" "unprognostic (1.59e-1)" "unprognostic (8.80e-3)" "unprognostic (3.95e-3)" "unprognostic (1.33e-1)" "unprognostic (4.15e-2)" "unprognostic (1.99e-2)" "unprognostic (5.42e-3)" "unprognostic (3.68e-1)" "unprognostic (1.02e-2)" "unprognostic (2.76e-2)" "unprognostic (2.19e-1)" "unprognostic (1.51e-1)" "unprognostic (1.18e-2)" 7.5 2.5 4.9 1.0 4.5 29.4 6.3 4.7 4.4 2.9 3.0 2.1 0.8 2.9 0.6 1.8 3.5 2.3 5.9 4.6 4.6 4.4 1.5 13.0 1.4 6.5 7.1 1.2 0.9 0.9 1.7 6.9 6.8 2.1 1.3 0.2 1.1 0.8 2.1 1.7 3.1 2.7 6.9 7.1 1.8 0.9 6.4 0.4 5.4 2.5 0.7 2.4 2.5 6.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.3 0.0 0.1 0.0 0.0 0.0 0.0 10.6 0.0 0.0 0.2 0.1 153.7 0.0 0.0 0.0 0.0 70.6 0.0 0.0 0.0 0.0 0.0 31.2 60.0 48.9 0.1 0.0 0.0 26.3 0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.1 0.0 0.1 0.0 0.1 34.4 0.0 0.8 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.1 0.0 0.0 0.0 0.5 4.9 4.5 4.7 4.4 4.6 4.6 6.5 7.1 6.8 6.9 6.4 6.8 23.9 0.0 0.0 0.0 0.5 0.9 0.0 0.0 0.0 0.0 0.1 0.1 3.7 1.5 1.3 1.8 0.0 0.1 0.0 0.0 0.0 0.1 5.3 0.0 0.1 18.1 0.0 151.5 0.0 0.0 0.3 0.6 0.0 0.0 36.8 0.0 26.7 0.1 10.6 0.0 0.1 0.0 0.0 1.6 1.5 18.2 0.0 4.8 1.8 29.0 0.8 0.0 1.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.1 0.0 0.3 0.4 1.3 0.4 0.1 1.0 0.0 2.0 0.0 0.0 0.0 TCF3 "bHLHb21, E2A, E47, ITF1, MGC129647, MGC129648, p75, VDIR" ENSG00000071564 "Transcription factor 3" P15923 19 1609290-1652615 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Differentiation, Neurogenesis, Transcription, Transcription regulation" DNA-binding "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "REH: 467.3;U-698: 597.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB018351, HPA049808, HPA062476" Approved Enhanced Nucleoplasm No No "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" Nucleoplasm "CAB018351: AB_675504, HPA049808: AB_2680892, HPA062476: AB_2684775" "unprognostic (8.82e-2)" "unprognostic (4.74e-2)" "unprognostic (1.26e-2)" "unprognostic (1.25e-1)" "unprognostic (1.91e-2)" "unprognostic (8.25e-3)" "prognostic unfavorable (2.46e-4)" "unprognostic (2.07e-2)" "unprognostic (7.99e-2)" "unprognostic (2.35e-1)" "unprognostic (2.42e-1)" "unprognostic (9.29e-3)" "prognostic unfavorable (1.53e-4)" "unprognostic (4.87e-3)" "unprognostic (1.88e-1)" "unprognostic (3.07e-1)" "unprognostic (8.05e-2)" 23.8 17.9 20.7 49.2 20.0 72.8 26.1 18.1 22.7 33.4 21.9 32.3 35.5 29.6 16.2 28.2 25.5 19.8 22.8 19.1 17.8 27.2 18.9 25.9 86.6 22.0 19.3 35.1 28.4 10.2 26.2 17.9 20.4 27.3 18.7 11.0 26.4 12.0 19.5 32.9 48.0 14.4 18.3 62.5 27.3 74.8 20.3 68.4 31.6 12.5 61.0 27.4 27.4 21.8 83.6 48.6 146.4 139.8 18.6 49.6 50.4 51.9 48.0 67.8 60.6 89.8 68.7 421.7 53.5 50.1 12.7 98.4 87.9 69.2 42.8 253.7 52.4 43.2 71.2 115.2 44.8 105.7 56.8 34.0 75.1 52.4 39.2 64.0 82.5 176.1 163.8 146.6 46.0 158.2 301.1 107.8 187.1 65.1 49.2 467.3 61.7 104.3 46.5 78.5 119.3 175.7 50.1 55.9 70.8 53.0 63.8 191.7 103.2 87.1 90.5 116.0 94.1 353.5 173.5 597.2 63.1 140.3 80.1 3.3 1.2 1.0 3.6 1.5 3.6 10.0 2.1 3.1 2.8 10.6 2.8 4.3 0.4 2.8 3.2 12.9 2.2 1.7 20.7 20.0 18.1 22.7 19.1 17.8 22.0 19.3 20.4 18.3 20.3 21.8 17.3 6.4 9.1 14.7 33.9 13.9 5.3 10.0 4.6 12.3 16.6 16.1 10.7 4.3 10.8 1.8 27.1 4.3 26.5 14.7 1.9 11.4 8.6 9.9 20.4 13.5 16.2 32.2 3.9 6.9 8.9 12.3 14.8 16.6 7.0 27.8 9.7 4.8 7.7 5.0 5.6 16.5 16.2 8.9 12.3 5.2 13.7 9.4 10.6 6.5 8.1 9.2 10.3 3.0 7.3 17.6 13.3 10.1 31.1 13.0 16.4 6.3 2.9 13.8 19.7 8.2 16.9 5.5 46.2 9.0 13.2 2.9 12.5 10.4 20.1 8.5 TERT "EST2, hEST2, TCS1, TP2, TRT" ENSG00000164362 "Telomerase reverse transcriptase" O14746 5 1253147-1295068 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins" "DNA-binding, Nucleotidyltransferase, Ribonucleoprotein, RNA-directed DNA polymerase, Transferase" "Cancer-related genes, Disease variant, Dyskeratosis congenita" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 1.4;Intestinal goblet cells: 1.0;Plasma cells: 2.8;Spermatocytes: 1.5;Spermatogonia: 4.1" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC TERT1: 438.0;fHDF/TERT166: 429.4;HBEC3-KT: 929.2;hTEC/SVTERT24-B: 560.1;LHCN-M2: 252.2;TIME: 799.9" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA054641, HPA065897" Supported Supported "Nucleoplasm,Nuclear speckles,Cytosol" NA NA "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 55: Plasma cells - Humoral immune response" Nucleoplasm "Nuclear speckles, Cytosol" "HPA054641: AB_2682554, HPA065897: AB_2685576" "unprognostic (1.21e-2)" "unprognostic (2.88e-2)" "unprognostic (1.24e-3)" "unprognostic (1.53e-1)" "unprognostic (1.43e-3)" "unprognostic (6.42e-3)" "unprognostic (1.85e-2)" "unprognostic (2.21e-1)" "unprognostic (6.91e-2)" "unprognostic (1.89e-1)" "unprognostic (3.59e-1)" "unprognostic (9.16e-4)" "unprognostic (8.84e-11)" "unprognostic (1.92e-1)" "unprognostic (2.15e-1)" "unprognostic (3.35e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.5 213.2 438.0 3.2 0.0 173.9 31.7 59.4 0.3 0.1 3.0 0.2 429.4 0.1 0.1 1.0 929.2 29.1 0.0 1.7 0.1 0.0 0.4 0.1 0.5 1.2 0.0 22.9 560.1 6.8 1.3 1.5 1.8 2.9 0.2 252.2 0.4 0.2 9.4 2.9 0.1 1.3 2.1 0.0 5.4 23.9 0.5 0.2 2.1 0.1 0.0 0.2 0.0 0.1 0.3 799.9 0.0 0.0 0.0 0.0 0.9 0.5 0.7 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.1 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 4.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 TET2 "FLJ20032, KIAA1546" ENSG00000168769 "Tet methylcytosine dioxygenase 2" Q6N021 4 105145875-105279816 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Cell cycle" "Chromatin regulator, Dioxygenase, DNA-binding, Oxidoreductase" "Cancer-related genes, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Oligodendrocyte precursor cells: 112.6;Oligodendrocytes: 128.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 55.5" "Lineage enriched" "Detected in all" 4 "granulocytes: 55.5" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA043135 Supported Approved Nucleoplasm NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 2: Karpas-707 - Immune response" "Cluster 41: Macrophages - Immune response" Nucleoplasm "HPA043135: AB_10794177" "unprognostic (6.83e-2)" "unprognostic (3.52e-2)" "unprognostic (1.69e-2)" "unprognostic (9.42e-2)" "unprognostic (4.15e-2)" "unprognostic (5.88e-2)" "unprognostic (6.12e-2)" "unprognostic (1.19e-3)" "unprognostic (1.15e-2)" "unprognostic (1.57e-2)" "unprognostic (5.77e-2)" "unprognostic (7.29e-2)" "unprognostic (2.70e-3)" "unprognostic (6.10e-2)" "unprognostic (1.89e-1)" "unprognostic (9.15e-2)" "unprognostic (7.84e-2)" 4.3 3.1 2.9 10.1 4.4 22.4 5.4 2.5 2.7 6.3 5.8 5.2 6.1 7.2 6.0 7.7 4.9 5.0 3.3 2.1 4.6 4.1 4.2 5.4 5.6 5.3 4.4 4.3 3.7 4.6 1.8 10.2 5.3 4.4 5.9 6.6 4.7 3.3 2.8 11.0 6.0 5.7 2.9 7.2 5.3 1.3 4.1 5.4 4.2 5.2 7.0 5.5 4.5 5.6 5.1 3.1 10.9 11.1 2.1 3.7 4.2 3.1 4.8 4.8 4.7 3.1 6.4 0.5 4.0 4.0 2.1 4.9 9.3 6.1 5.3 6.7 2.9 7.0 6.5 1.6 4.9 15.5 11.8 3.8 7.9 4.5 5.6 8.6 6.4 4.1 7.7 13.6 4.4 3.1 2.5 4.7 2.5 6.2 2.2 8.4 4.7 1.0 4.7 9.4 7.5 5.9 4.2 9.1 0.8 5.9 4.5 11.8 9.1 7.8 6.7 2.1 5.3 9.5 6.8 6.8 4.8 3.8 7.2 30.1 13.6 14.7 3.9 10.4 1.6 5.3 2.3 2.2 10.2 6.3 1.9 2.9 55.5 5.9 13.6 8.9 3.1 3.3 2.9 4.4 2.5 2.7 2.1 4.6 5.3 4.4 5.3 2.9 4.1 5.6 24.5 25.6 29.1 58.8 28.3 14.4 11.0 14.2 12.5 22.8 15.6 13.6 27.9 5.7 23.9 9.2 16.7 23.1 34.1 19.0 7.9 7.0 0.4 22.1 38.3 20.3 23.3 10.9 48.4 7.5 5.7 18.0 21.4 33.2 27.8 15.5 13.6 8.5 14.5 35.3 89.7 15.8 32.6 48.8 93.3 0.9 8.1 98.3 5.4 90.9 48.1 5.8 34.0 112.6 128.3 8.2 18.7 7.2 22.5 12.1 16.3 2.8 22.3 24.3 13.1 47.0 21.7 0.2 1.3 28.4 35.9 34.2 18.9 24.7 14.0 27.5 TFE3 "bHLHe33, TFEA" ENSG00000068323 "Transcription factor binding to IGHM enhancer 3" P19532 X 49028726-49043410 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Adaptive immunity, Immunity, Transcription, Transcription regulation" "Activator, DNA-binding" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 12.5" "Group enriched" "Detected in many" 4 "granulocytes: 12.5;monocytes: 6.3" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA023881 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 57: Non-specific - Angiogenesis" "Cluster 30: Epithelial cell lines - Translation" "Cluster 41: Macrophages - Immune response" "Nucleoplasm, Cytosol" "HPA023881: AB_1857931" "unprognostic (2.68e-2)" "unprognostic (2.89e-3)" "unprognostic (2.40e-2)" "unprognostic (5.36e-2)" "unprognostic (2.71e-2)" "unprognostic (1.81e-1)" "prognostic unfavorable (6.03e-5)" "unprognostic (2.40e-1)" "unprognostic (1.26e-1)" "unprognostic (4.32e-2)" "unprognostic (5.41e-2)" "unprognostic (1.16e-1)" "prognostic unfavorable (2.19e-8)" "unprognostic (1.93e-1)" "unprognostic (8.77e-2)" "unprognostic (4.19e-2)" "unprognostic (6.25e-1)" 31.3 23.6 27.8 16.8 27.3 24.1 22.9 25.8 26.9 24.1 23.3 23.6 10.8 24.7 21.1 15.6 26.2 18.5 17.2 25.7 29.4 15.1 12.6 29.2 11.8 37.2 30.9 25.8 12.4 25.1 18.4 20.8 28.7 17.2 11.5 14.8 13.4 28.3 17.0 20.5 14.7 24.7 27.5 22.5 16.8 5.9 32.2 10.7 20.0 14.0 13.2 25.0 20.5 25.6 32.8 41.5 14.6 44.6 48.6 45.1 12.5 40.6 55.8 49.7 38.2 23.3 26.8 10.2 18.0 65.7 48.6 25.5 25.4 40.2 44.8 24.4 11.8 8.3 39.6 26.2 69.0 10.0 28.3 38.5 32.3 64.4 50.1 47.8 26.3 8.4 19.8 55.9 49.2 20.6 7.5 17.2 36.3 11.0 34.1 11.9 22.2 26.6 43.1 18.0 12.4 12.4 44.8 19.0 17.9 52.5 27.6 15.0 48.5 47.1 48.7 48.0 27.3 30.1 29.7 8.0 56.1 14.0 33.2 0.0 4.8 1.8 0.6 4.7 1.1 0.5 0.9 0.5 2.2 1.0 0.6 0.5 12.5 0.4 6.3 0.5 1.3 2.6 27.8 27.3 25.8 26.9 25.7 29.4 37.2 30.9 28.7 27.5 32.2 25.6 13.8 16.0 8.8 13.7 9.8 19.8 19.7 11.2 30.1 6.8 10.9 9.4 8.1 15.7 11.8 20.2 4.2 16.0 4.4 14.3 9.8 17.7 0.7 10.9 15.3 17.5 12.5 5.2 7.5 15.8 9.4 20.2 14.3 14.8 5.7 12.0 10.8 15.0 22.3 18.5 7.2 8.2 0.0 21.7 29.4 2.2 27.4 20.5 8.8 11.2 15.5 12.0 4.1 6.0 7.7 21.4 13.7 24.5 12.9 20.2 10.6 12.1 7.0 5.6 13.1 18.5 14.3 2.2 0.8 18.9 22.0 37.1 8.6 13.9 7.5 19.6 TFG "FLJ36137, SPG57, TF6" ENSG00000114354 "Trafficking from ER to golgi regulator" Q92734 3 100709295-100748964 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "ER-Golgi transport, Transport" "Cancer-related genes, Disease variant, Hereditary spastic paraplegia, Neurodegeneration, Neuropathy, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019473, HPA052206" Approved Supported Vesicles,Cytosol No No 320000 "Cluster 38: Basophils - Unknown function" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 30: Epithelial cell lines - Translation" "Cluster 55: Plasma cells - Humoral immune response" Vesicles Cytosol "HPA019473: AB_1857936, HPA052206: AB_2681760" "unprognostic (1.14e-1)" "unprognostic (3.58e-2)" "unprognostic (1.46e-1)" "unprognostic (2.94e-2)" "unprognostic (1.46e-1)" "unprognostic (4.14e-2)" "prognostic unfavorable (5.48e-4)" "unprognostic (3.31e-3)" "unprognostic (1.42e-1)" "unprognostic (3.73e-2)" "prognostic unfavorable (1.50e-4)" "unprognostic (4.58e-3)" "unprognostic (3.72e-2)" "unprognostic (2.82e-1)" "unprognostic (8.55e-2)" "unprognostic (3.33e-1)" "unprognostic (8.45e-2)" 62.2 73.0 40.7 37.2 40.4 37.4 52.4 43.5 46.4 53.9 46.7 63.8 89.8 52.0 78.5 85.7 51.2 56.4 82.6 41.3 45.4 71.9 113.9 55.6 29.4 44.2 43.2 48.2 66.7 89.0 64.1 79.2 44.4 47.9 69.6 40.9 60.6 61.3 75.5 58.9 76.6 66.5 43.2 42.6 54.4 47.7 42.3 40.6 64.1 58.2 54.9 61.6 57.3 44.4 203.8 107.5 126.7 79.0 160.1 176.4 163.9 141.1 190.4 182.5 213.0 136.0 96.1 24.7 103.3 180.4 141.3 143.1 143.4 161.5 216.2 123.8 87.4 99.7 69.3 130.0 183.3 70.2 51.8 149.3 216.6 108.4 190.8 165.1 165.5 44.5 73.1 63.5 191.9 143.9 63.3 56.7 122.5 193.8 169.3 55.5 77.8 89.0 226.5 125.9 96.4 93.1 95.0 118.2 175.8 103.4 141.7 103.1 113.1 103.0 130.8 48.4 104.4 56.2 65.8 92.1 171.2 79.7 130.7 84.3 43.6 42.8 30.8 45.2 37.4 37.4 31.6 34.5 43.1 35.9 29.4 29.7 26.1 43.1 44.8 29.3 41.0 37.0 40.7 40.4 43.5 46.4 41.3 45.4 44.2 43.2 44.4 43.2 42.3 44.4 67.9 60.9 36.9 46.4 43.3 136.6 105.9 183.6 69.4 46.8 58.0 50.2 83.5 48.6 93.1 36.8 25.0 211.6 43.1 111.8 137.0 190.3 101.5 70.8 70.4 70.2 52.6 27.1 54.8 107.7 201.5 97.8 47.4 79.0 76.8 62.9 53.9 68.4 86.2 57.2 59.2 128.5 122.1 27.3 84.9 45.5 70.8 43.6 64.0 38.4 98.5 88.0 28.8 49.3 55.0 130.5 91.0 74.1 75.8 133.5 202.5 106.4 63.9 60.3 39.5 81.3 87.2 79.2 51.5 68.0 118.9 284.4 43.2 90.0 97.2 123.0 TGFA ENSG00000163235 "Transforming growth factor alpha" P01135 2 70447284-70554193 "Cancer-related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" "Growth factor, Mitogen" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 27.3" "Cell type enhanced" "Detected in many" "Oligodendrocyte precursor cells: 59.3;Pancreatic endocrine cells: 74.5;Urothelial cells: 63.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "basophil: 11.3;eosinophil: 23.8;neutrophil: 23.8" "Lineage enriched" "Detected in many" 5 "granulocytes: 23.8" "Cell line enhanced" "Detected in many" "A-431: 72.5;CAPAN-2: 82.5;HBEC3-KT: 72.3;OE19: 54.6;RPTEC TERT1: 72.6;U-87 MG: 69.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042297 Approved Approved Vesicles "Secreted to blood" No No 57900 "Cluster 52: Eosinophils - Transcription" "Cluster 27: Brain & Skin - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 22: Epithelial cell types - Mixed function" Vesicles "HPA042297: AB_10793878" "unprognostic (1.23e-1)" "unprognostic (1.06e-3)" "unprognostic (3.57e-3)" "unprognostic (6.39e-2)" "unprognostic (1.41e-1)" "unprognostic (8.49e-3)" "unprognostic (1.52e-1)" "unprognostic (3.00e-3)" "unprognostic (6.69e-2)" "unprognostic (9.21e-2)" "prognostic unfavorable (1.20e-5)" "unprognostic (7.74e-2)" "unprognostic (3.70e-2)" "unprognostic (1.60e-1)" "unprognostic (9.21e-2)" "prognostic favorable (1.52e-4)" "unprognostic (9.19e-2)" 2.2 0.5 9.2 5.0 16.8 1.6 6.9 15.0 12.2 6.1 5.2 10.7 8.5 1.3 2.9 25.5 6.1 14.1 0.7 10.4 11.7 13.4 4.5 3.9 4.1 21.0 15.8 0.1 7.5 3.0 0.5 1.9 18.5 2.4 7.9 7.4 6.4 1.2 0.1 12.2 10.0 1.4 16.6 5.8 8.5 2.5 13.2 1.0 8.1 0.3 9.0 10.0 12.8 27.3 72.5 11.3 0.1 0.2 0.0 0.0 0.0 11.0 0.0 0.3 0.1 0.2 82.5 0.0 43.2 0.4 11.2 37.1 0.6 72.3 0.1 0.1 1.6 0.0 1.8 6.0 0.0 0.9 0.1 0.0 29.1 0.1 27.8 3.4 0.0 5.6 0.0 0.4 0.0 2.6 0.1 1.4 1.1 54.6 22.9 0.0 0.5 19.8 72.6 27.2 0.6 0.1 5.8 0.0 0.1 0.2 9.8 0.7 0.6 0.3 4.9 0.1 15.7 0.4 0.6 0.1 69.0 2.4 25.6 11.3 0.8 23.8 1.7 0.2 4.4 0.0 1.0 1.0 1.0 0.0 0.5 0.4 23.8 0.3 0.0 0.0 0.0 0.7 9.2 16.8 15.0 12.2 10.4 11.7 21.0 15.8 18.5 16.6 13.2 27.3 0.4 6.4 2.7 0.3 0.2 16.2 12.3 16.9 10.8 1.4 9.8 12.1 2.3 24.3 21.8 25.8 0.0 0.0 2.2 19.8 1.9 37.3 21.3 8.1 0.7 1.7 1.2 0.0 0.8 10.0 0.0 0.6 13.7 10.5 5.7 0.0 0.0 3.0 3.9 0.0 3.6 6.2 12.2 3.2 2.4 1.9 0.3 4.1 0.0 6.5 18.2 7.9 2.1 59.3 36.1 74.5 9.0 0.0 0.7 16.8 21.1 6.6 20.4 0.7 0.0 0.1 1.1 0.6 0.2 12.2 24.9 0.0 1.9 0.0 5.6 63.6 TGFBR1 "ACVRLK4, ALK-5, ALK5, ESS1, MSSE, TBR-i, TBRI" ENSG00000106799 "Transforming growth factor beta receptor 1" P36897 9 99104038-99154192 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Differentiation, Growth regulation" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Aortic aneurysm, Craniosynostosis, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 128.4;Late spermatids: 101.7;Microglial cells: 116.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RH-30: 253.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002441, CAB031481, HPA056473" Uncertain Supported "Plasma membrane" "Intracellular and membrane" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 65: Plasmacytoid DCs - Unknown function" "Plasma membrane" "CAB002441: AB_564029, CAB031481: AB_2202455, HPA056473: AB_2683144" "unprognostic (2.58e-3)" "unprognostic (1.20e-2)" "unprognostic (3.64e-3)" "unprognostic (2.80e-1)" "unprognostic (8.63e-2)" "unprognostic (3.36e-2)" "unprognostic (1.97e-2)" "unprognostic (1.32e-3)" "unprognostic (1.97e-1)" "unprognostic (1.45e-1)" "unprognostic (8.21e-3)" "unprognostic (1.82e-1)" "unprognostic (1.18e-1)" "unprognostic (1.01e-3)" "unprognostic (3.40e-2)" "unprognostic (3.19e-2)" "unprognostic (1.14e-2)" 15.9 9.9 9.8 18.2 9.3 33.7 15.4 13.2 8.9 19.4 11.8 18.8 11.7 20.6 8.8 15.0 8.5 21.7 8.2 6.8 11.3 22.6 14.8 16.3 13.8 18.4 14.5 13.0 8.3 8.5 7.6 48.8 20.0 17.1 13.4 4.7 8.3 16.8 8.7 6.2 9.3 33.0 18.0 16.5 18.4 18.3 17.5 11.2 11.2 13.2 13.6 22.5 8.4 27.9 13.7 19.5 115.5 36.1 26.2 19.3 17.4 44.1 47.8 40.7 44.9 19.9 9.3 29.7 13.4 34.6 32.1 30.4 39.6 34.1 54.0 77.1 12.3 43.9 20.7 17.8 43.2 27.2 102.8 40.2 35.4 62.8 29.5 25.2 7.4 10.9 62.4 12.1 55.4 20.3 4.0 31.0 24.7 12.2 11.5 11.0 253.1 12.5 9.9 3.8 31.1 36.2 34.3 150.2 46.4 47.3 28.1 36.6 13.6 29.8 25.5 129.3 27.3 12.1 13.4 20.0 62.5 45.9 26.2 16.2 2.4 9.5 7.8 1.6 6.7 1.6 3.3 5.8 2.0 1.2 3.2 6.2 4.9 4.3 2.0 1.4 2.4 2.2 9.8 9.3 13.2 8.9 6.8 11.3 18.4 14.5 20.0 18.0 17.5 27.9 13.5 6.4 8.8 18.9 18.9 23.6 7.4 19.9 44.3 8.0 18.9 11.7 7.6 4.3 12.8 60.7 0.0 23.0 37.3 5.0 0.0 18.8 128.4 6.4 22.7 17.6 9.6 7.4 14.2 31.2 6.7 36.0 9.2 9.3 29.9 19.5 6.4 12.7 49.4 0.0 8.6 7.3 8.2 32.4 52.5 101.7 9.6 39.7 35.6 116.2 24.3 3.1 35.0 45.8 21.1 33.8 4.2 13.5 11.9 18.4 3.6 13.8 5.0 2.0 32.9 21.8 20.9 11.0 12.7 25.6 16.2 19.4 25.4 7.6 8.3 11.5 TGFBR2 "MFS2, TBR-ii, TBRII" ENSG00000163513 "Transforming growth factor beta receptor 2" P37173 3 30606601-30694142 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Apoptosis, Differentiation, Growth regulation" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Aortic aneurysm, Cancer-related genes, Craniosynostosis, Disease variant, FDA approved drug targets, Hereditary nonpolyposis colorectal cancer" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 391.5;Endothelial cells: 236.4;Hepatic stellate cells: 478.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC diff: 313.6;ASC TERT1: 472.3;HSkMC: 430.0;LHCN-M2: 381.7;TIME: 418.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB073537 Supported "Plasma membrane" NA NA 810000 "Cluster 5: Granulocytes - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Plasma membrane" "CAB073537: " "unprognostic (1.74e-1)" "unprognostic (1.84e-2)" "unprognostic (3.70e-1)" "unprognostic (3.02e-2)" "unprognostic (1.92e-1)" "unprognostic (2.26e-1)" "unprognostic (1.96e-1)" "unprognostic (1.62e-1)" "unprognostic (1.40e-1)" "unprognostic (2.24e-2)" "unprognostic (7.36e-2)" "unprognostic (1.12e-1)" "unprognostic (1.65e-2)" "unprognostic (4.72e-2)" "unprognostic (1.81e-2)" "unprognostic (8.81e-2)" "unprognostic (8.02e-2)" 230.0 56.1 16.5 73.8 12.9 29.4 145.7 13.8 19.3 90.0 30.6 96.0 44.2 69.1 18.2 44.9 69.6 91.9 95.2 10.6 13.4 67.9 59.1 148.0 70.1 17.6 16.5 26.6 52.0 59.0 16.9 81.6 16.7 44.1 54.1 2.1 49.2 60.8 31.1 39.1 77.7 107.2 17.3 111.1 63.4 7.8 21.5 49.7 91.8 62.2 60.7 98.0 55.1 17.2 16.6 100.2 5.3 0.1 313.6 472.3 15.9 83.9 116.1 28.5 27.7 22.9 86.6 2.2 298.2 117.2 32.2 33.3 4.0 125.4 42.0 7.0 8.9 10.1 10.7 104.5 128.5 14.9 76.6 430.0 93.6 126.3 114.4 117.0 296.0 10.9 1.8 0.0 381.7 1.3 16.2 10.5 2.2 75.7 39.8 14.1 36.4 2.1 113.5 40.5 0.1 5.6 24.9 6.1 22.0 6.6 0.0 14.0 418.6 134.7 33.2 61.4 32.0 2.8 0.3 12.5 80.1 16.1 55.8 9.0 3.0 11.5 3.4 3.1 3.3 4.5 4.8 3.3 2.6 6.4 16.6 7.3 13.1 1.9 8.0 6.6 0.7 3.8 16.5 12.9 13.8 19.3 10.6 13.4 17.6 16.5 16.7 17.3 21.5 17.2 391.5 144.2 99.7 0.7 77.0 37.3 18.9 23.5 39.9 5.1 23.7 24.1 84.5 50.1 39.5 27.6 0.0 6.8 85.3 10.5 3.9 13.1 2.5 28.3 57.5 236.4 8.4 20.4 0.4 15.8 5.1 129.2 39.3 30.8 29.8 0.7 478.0 55.5 30.4 0.0 1.0 12.4 22.4 147.0 58.0 3.8 32.9 67.9 30.2 170.5 47.5 0.2 56.7 6.0 2.4 37.6 12.1 47.4 37.5 8.6 13.6 7.2 14.7 1.2 32.9 60.8 53.4 0.3 1.2 8.0 30.5 3.7 68.2 1.7 14.5 10.8 TLX1 "HOX11, TCL3" ENSG00000107807 "T cell leukemia homeobox 1" P31314 10 101131300-101137789 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Developmental protein, DNA-binding" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 29 "lymphoid tissue: 43.9;salivary gland: 16.5" "Not detected" "Not detected" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in single" "medulla oblongata: 1.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HAP1: 5.5;HEK 293: 2.5;K-562: 13.8;SCLC-21H: 2.2;SH-SY5Y: 3.3;SiHa: 2.7" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 64: Macrophages - Immune response" "Cluster 1: K-562 - Erythropoiesis" "Cluster 43: Cardiomyocytes - Nuclear processes" "unprognostic (8.67e-2)" "unprognostic (2.23e-1)" "prognostic unfavorable (7.32e-4)" "unprognostic (1.06e-5)" "unprognostic (1.06e-1)" "unprognostic (1.60e-1)" "unprognostic (5.07e-1)" "unprognostic (1.57e-2)" "unprognostic (2.12e-2)" "unprognostic (2.69e-2)" "unprognostic (2.52e-3)" "unprognostic (1.81e-1)" "unprognostic (2.63e-1)" "unprognostic (3.26e-1)" "unprognostic (3.06e-1)" "unprognostic (7.35e-2)" 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.9 0.0 0.0 1.0 0.0 0.0 0.1 0.3 0.0 0.1 0.7 0.0 0.1 0.0 16.5 0.0 0.0 0.0 0.8 0.0 0.0 43.9 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.6 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.1 0.0 5.5 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.2 3.3 2.7 0.0 0.0 0.2 0.1 0.4 0.1 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.2 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.3 0.0 TLX3 "HOX11L2, RNX" ENSG00000164438 "T cell leukemia homeobox 3" O43711 5 171309248-171312139 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Developmental protein, DNA-binding" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 27 "brain: 9.0" "Cell type enriched" "Detected in some" 6 "Extravillous trophoblasts: 7.7" "Cancer enhanced" "Detected in some" "cervical cancer: 1.7" "Group enriched" "Detected in many" 6 "cerebellum: 9.0;medulla oblongata: 2.3;spinal cord: 5.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "SH-SY5Y: 25.9" "Region enriched" "Detected in single" 7 "cerebellum: 2.2" "Region enriched" "Detected in some" 8 "cerebellum: 15.5" "HPA030504, HPA060957, HPA069359" Enhanced Enhanced Nucleoplasm NA NA "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 38: Extravillous trophoblasts - Unknown function" Nucleoplasm "HPA030504: AB_2732458, HPA060957: AB_2732655, HPA069359: AB_2732130" "unprognostic (3.52e-2)" "unprognostic (2.43e-2)" "unprognostic (2.09e-1)" "unprognostic (3.11e-1)" "unprognostic (9.80e-2)" "unprognostic (2.76e-2)" "unprognostic (4.48e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.6 0.0 0.0 0.0 0.3 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.7 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.4 0.0 4.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.1 0.0 0.2 0.0 0.0 25.9 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.0 0.4 0.0 0.0 2.3 0.6 1.0 5.3 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 1.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 7.7 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 TMEM127 "FLJ20507, FLJ22257" ENSG00000135956 "Transmembrane protein 127" O75204 2 96248514-96265997 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted membrane proteins" "Cancer-related genes, Tumor suppressor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 88.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "unprognostic (5.15e-3)" "unprognostic (2.67e-1)" "unprognostic (1.72e-2)" "unprognostic (6.51e-2)" "unprognostic (5.82e-2)" "unprognostic (2.05e-1)" "prognostic unfavorable (6.59e-4)" "unprognostic (6.73e-2)" "unprognostic (4.25e-1)" "unprognostic (1.06e-2)" "unprognostic (7.50e-2)" "unprognostic (2.17e-1)" "prognostic favorable (6.69e-5)" "unprognostic (3.59e-1)" "unprognostic (1.52e-1)" "unprognostic (5.15e-2)" "unprognostic (3.65e-2)" 29.3 34.6 25.9 28.5 24.6 53.0 25.6 20.1 30.6 30.7 15.7 34.4 32.6 30.0 21.4 40.0 25.2 32.3 67.8 26.7 23.6 29.5 35.4 31.6 21.4 24.5 26.3 31.9 28.5 73.1 29.4 26.8 24.5 26.1 30.5 27.6 39.7 42.4 25.9 33.0 34.7 35.1 21.1 34.7 27.8 10.2 29.7 19.1 26.2 30.6 25.4 38.6 27.8 21.9 28.8 38.0 19.9 30.7 86.0 43.3 36.7 36.9 65.9 38.6 35.2 37.9 40.0 17.9 52.8 73.3 67.8 45.1 23.1 34.2 26.8 36.1 17.8 31.2 17.6 37.5 55.4 26.7 54.0 52.7 48.0 48.0 35.3 51.4 44.5 12.1 19.5 37.6 39.8 32.8 17.6 16.8 27.3 33.9 40.4 16.4 25.0 26.9 42.9 48.7 22.3 23.4 27.1 63.8 31.3 40.2 23.6 28.2 52.5 63.9 36.2 55.9 25.8 28.2 29.6 14.1 42.6 30.9 34.7 3.9 6.3 8.2 2.8 6.6 3.0 1.8 2.1 3.0 4.3 1.9 1.6 2.2 14.3 1.5 5.3 2.5 1.6 3.2 25.9 24.6 20.1 30.6 26.7 23.6 24.5 26.3 24.5 21.1 29.7 21.9 24.8 19.2 15.3 7.2 13.4 17.2 16.6 14.5 12.0 22.1 20.0 12.8 39.6 22.8 20.2 27.6 27.1 11.4 19.3 88.2 15.6 29.7 5.2 16.4 15.1 23.1 16.3 9.0 12.9 34.8 13.1 16.7 14.8 28.8 13.9 13.6 29.6 35.7 37.7 21.9 15.7 26.7 12.2 59.8 33.2 5.8 13.7 34.0 16.0 5.6 41.9 7.8 15.5 8.0 6.6 41.0 35.1 17.0 13.0 23.1 43.9 13.3 15.7 16.9 6.6 18.5 19.4 9.1 2.9 12.6 23.3 24.2 14.3 15.9 18.6 34.1 TNFAIP3 "A20, OTUD7C" ENSG00000118503 "TNF alpha induced protein 3" P21580 6 137867214-137883312 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Inflammatory response, Ubl conjugation pathway" "DNA-binding, Hydrolase, Multifunctional enzyme, Protease, Thiol protease, Transferase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 519.5" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 774.9;Endometrial ciliated cells: 605.2;Glandular and luminal cells: 1498.3;Macrophages: 596.6;Suprabasal keratinocytes: 745.7;T-cells: 624.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "GAMG: 106.5;Karpas-707: 161.3;REH: 151.5;U-266/84: 131.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002116 Approved Approved Centrosome,Cytosol NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 2: Karpas-707 - Immune response" "Cluster 41: Macrophages - Immune response" "Centrosome, Cytosol" "HPA002116: AB_1858162" "unprognostic (5.50e-3)" "unprognostic (9.98e-3)" "unprognostic (3.06e-2)" "unprognostic (1.01e-2)" "unprognostic (4.01e-2)" "unprognostic (9.47e-2)" "unprognostic (5.01e-3)" "unprognostic (4.40e-2)" "unprognostic (2.92e-2)" "unprognostic (2.58e-1)" "unprognostic (1.72e-1)" "unprognostic (2.06e-1)" "prognostic unfavorable (6.05e-4)" "unprognostic (6.06e-2)" "unprognostic (3.55e-3)" "unprognostic (1.27e-1)" "unprognostic (6.29e-2)" 57.0 15.6 4.4 114.6 3.8 519.5 23.3 2.9 23.9 27.5 12.0 22.6 21.4 31.3 5.2 26.6 23.4 47.8 23.0 3.2 2.8 13.8 27.4 56.2 76.8 6.1 3.9 73.2 25.8 25.8 7.5 28.9 6.7 17.3 24.7 19.1 16.1 10.3 8.6 50.5 30.7 33.5 6.6 46.1 22.8 8.3 9.5 71.1 11.7 3.8 55.7 171.1 14.6 6.2 32.6 4.8 1.8 2.8 10.1 16.9 7.8 18.8 67.6 4.8 5.7 34.9 8.8 7.3 43.1 20.0 106.5 22.6 1.1 50.4 8.9 46.8 2.2 7.5 19.8 21.1 11.2 10.3 12.8 15.6 7.3 56.4 53.6 5.6 2.9 21.2 17.4 161.3 8.4 1.8 56.2 41.4 1.5 2.1 1.4 151.5 39.4 6.1 14.8 15.1 0.7 0.3 3.6 5.3 16.9 7.0 3.4 11.7 14.8 46.9 6.8 46.0 9.6 48.7 131.4 14.0 16.9 13.1 6.1 7.3 12.6 9.6 19.6 9.3 27.9 7.4 19.4 18.0 14.3 7.8 13.1 10.1 13.6 11.1 5.1 26.2 19.2 14.8 4.4 3.8 2.9 23.9 3.2 2.8 6.1 3.9 6.7 6.6 9.5 6.2 71.8 38.5 76.3 2.0 94.5 774.9 150.2 102.1 384.7 1.1 29.0 42.3 4.6 25.8 53.7 0.0 29.2 8.1 395.5 53.9 1.9 60.0 2.6 605.2 365.9 114.8 11.9 5.2 0.1 26.9 104.8 110.1 111.1 1498.3 255.9 2.3 48.5 13.5 45.7 0.0 0.3 38.6 67.1 125.2 461.8 3.2 6.8 596.6 129.9 8.4 59.1 1.7 14.4 2.0 0.3 30.5 29.5 6.0 331.4 170.2 37.3 3.1 84.3 13.3 6.6 29.0 94.9 2.7 2.2 367.9 745.7 23.1 624.2 14.9 20.9 78.1 TNFRSF14 "ATAR, CD270, HVEA, HVEM, LIGHTR, TR2" ENSG00000157873 "TNF receptor superfamily member 14" Q92956 1 2555639-2565382 "Cancer-related genes, CD markers, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Adaptive immunity, Host-virus interaction, Immunity, Innate immunity" "Host cell receptor for virus entry, Receptor" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Proximal enterocytes: 219.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "SK-MEL-30: 16.2" "Low region specificity" "Detected in all" "HPA006404, CAB026150, CAB030007" Approved NA NA 110000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 64: Macrophages - Immune response" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 63: NK-cells & T-cells - Immune response" "CAB026150: , CAB030007: AB_2303380, HPA006404: AB_1851348" "prognostic favorable (4.39e-5)" "unprognostic (3.48e-2)" "unprognostic (1.53e-2)" "prognostic favorable (8.01e-6)" "unprognostic (1.11e-2)" "unprognostic (6.83e-3)" "unprognostic (9.62e-3)" "unprognostic (2.32e-1)" "unprognostic (3.25e-1)" "unprognostic (1.62e-1)" "unprognostic (2.31e-1)" "unprognostic (1.64e-1)" "unprognostic (1.86e-2)" "unprognostic (1.16e-2)" "unprognostic (2.72e-2)" "unprognostic (1.58e-1)" "prognostic favorable (7.79e-6)" 37.0 71.8 2.4 6.2 2.2 5.0 34.8 2.2 6.6 52.5 3.9 57.6 16.9 32.9 1.2 26.4 39.9 4.4 23.8 2.7 2.4 57.1 61.8 58.0 10.0 2.6 2.3 33.0 20.4 3.9 24.4 2.8 2.4 50.4 5.5 0.6 35.3 2.3 6.5 22.2 67.5 1.2 2.1 100.7 45.9 7.5 2.7 2.8 29.4 1.0 4.0 33.6 37.3 2.6 0.6 0.3 0.3 8.7 2.3 9.1 2.7 2.5 8.5 4.9 6.5 0.7 6.3 2.4 0.5 7.7 2.8 4.4 0.0 3.2 0.7 11.4 0.0 6.1 0.8 1.0 9.1 3.3 6.8 4.4 2.6 2.6 0.6 4.3 5.8 0.4 1.9 11.9 4.5 0.0 4.4 0.3 0.1 2.4 4.4 2.8 0.0 0.6 0.4 3.7 0.1 0.2 0.0 0.4 16.2 0.0 1.5 0.7 5.9 0.3 1.8 0.8 0.4 8.1 2.2 1.2 0.5 2.7 1.5 2.2 31.4 5.5 40.2 68.2 23.3 42.4 47.2 27.0 23.2 50.1 51.3 39.4 78.4 12.8 50.9 33.2 62.8 39.3 2.4 2.2 2.2 6.6 2.7 2.4 2.6 2.3 2.4 2.1 2.7 2.6 63.7 19.2 38.0 5.5 97.6 16.4 31.2 50.3 23.3 1.5 36.0 33.8 8.3 47.1 51.5 35.0 0.0 1.2 90.9 94.7 3.9 16.8 0.3 19.9 18.4 52.7 36.1 18.7 8.8 32.9 1.5 27.1 77.5 25.8 53.2 8.3 41.4 20.0 88.8 0.0 0.9 78.4 22.4 80.1 59.3 2.6 20.8 91.3 46.2 17.8 106.1 15.9 131.8 2.5 1.3 24.6 115.8 13.9 70.4 29.8 219.6 35.5 34.7 0.7 19.7 9.0 22.0 0.1 0.4 15.6 13.4 1.2 84.4 16.0 101.4 44.3 TP53 "LFS1, p53" ENSG00000141510 "Tumor protein p53" P04637 17 7661779-7687538 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors, Transporters" "Apoptosis, Biological rhythms, Cell cycle, Host-virus interaction, Necrosis, Transcription, Transcription regulation" "Activator, DNA-binding, Repressor" "Cancer-related genes, Disease variant, Li-Fraumeni syndrome, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002973, CAB039238, CAB039239, HPA051244, HPA063532, CAB072876, CAB079965" Enhanced Supported Nucleoplasm,Mitochondria,Cytosol Yes No "Cluster 39: Non-specific - mRNA processing" "Cluster 3: T-cells - Adaptive immune response" "Cluster 14: REH - Unknown function" "Cluster 32: Non-specific - Translation" Nucleoplasm "Mitochondria, Cytosol" "CAB002973: AB_2206626, CAB039238: , CAB039239: , CAB072876: AB_2665731, CAB079965: , HPA051244: AB_2681403, HPA063532: " "unprognostic (2.29e-2)" "unprognostic (8.83e-3)" "unprognostic (1.26e-2)" "prognostic favorable (1.35e-4)" "unprognostic (9.95e-2)" "unprognostic (4.00e-2)" "unprognostic (2.79e-3)" "unprognostic (4.99e-2)" "unprognostic (2.75e-2)" "unprognostic (2.55e-1)" "unprognostic (1.30e-1)" "prognostic unfavorable (5.01e-4)" "unprognostic (1.86e-3)" "unprognostic (7.89e-3)" "unprognostic (8.05e-2)" "unprognostic (2.74e-1)" "unprognostic (1.08e-1)" 19.3 13.8 10.4 27.1 12.6 19.6 22.5 10.4 16.5 19.9 10.3 29.0 18.9 24.5 12.8 28.8 31.3 13.2 11.1 10.1 11.4 14.9 16.5 15.1 34.6 18.7 13.6 27.3 18.3 9.4 7.3 23.5 12.5 17.7 27.5 4.1 18.9 15.3 12.3 37.4 20.4 24.6 12.6 31.1 22.6 10.4 12.3 47.2 17.4 6.1 45.4 20.8 19.9 13.3 81.5 145.3 81.1 57.3 37.3 43.9 82.8 28.4 66.1 78.5 100.2 4.2 40.6 190.5 126.9 58.7 77.6 174.9 119.7 80.4 72.8 42.7 76.5 77.6 76.8 70.9 111.5 1.6 37.0 55.7 93.0 38.9 106.5 45.6 79.4 24.7 3.8 6.9 41.5 145.1 130.0 96.3 80.2 10.4 2.4 252.2 56.1 66.2 59.4 87.3 46.0 80.5 94.1 62.6 24.3 39.4 109.2 7.4 100.7 91.6 30.2 1.0 48.3 47.6 37.9 82.5 23.6 9.7 80.1 1.2 21.2 3.4 13.0 21.7 15.9 21.5 13.3 14.6 30.3 19.1 13.7 15.4 2.4 17.5 19.3 27.3 17.3 14.7 10.4 12.6 10.4 16.5 10.1 11.4 18.7 13.6 12.5 12.6 12.3 13.3 21.1 9.6 12.8 16.3 26.0 28.7 14.5 24.6 24.5 2.6 36.1 30.4 2.5 18.6 15.4 20.2 0.0 36.9 24.7 16.9 9.8 24.8 12.8 11.5 29.0 24.5 30.7 21.7 2.1 18.1 39.6 17.0 11.2 19.5 1.3 31.7 22.1 18.0 24.2 0.0 3.2 43.0 18.3 27.8 20.1 3.8 23.0 19.3 12.4 7.5 31.9 4.9 25.7 9.0 8.0 15.8 16.4 17.0 7.8 15.7 10.3 10.1 8.8 2.6 13.1 25.9 20.6 0.5 4.9 28.7 32.8 22.4 16.5 27.4 54.1 11.5 TPM3 "NEM1, TRK" ENSG00000143549 "Tropomyosin 3" P06753 1 154155304-154194648 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Actin-binding, Muscle protein" "Cancer-related genes, Disease variant, Nemaline myopathy, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 13 "skeletal muscle: 8905.8;tongue: 6106.5" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000261, HPA009066, HPA047089, HPA053624" Approved Approved "Actin filaments,Cytosol" NA NA 170000000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 17: WM-115 - Nervous system development" "Cluster 11: Alveolar cells - Smell perception" "Actin filaments" Cytosol "HPA000261: AB_1080339, HPA009066: AB_1080342, HPA047089: AB_2679928, HPA053624: AB_2682210" "unprognostic (1.64e-1)" "unprognostic (2.11e-2)" "unprognostic (3.01e-3)" "unprognostic (1.07e-1)" "unprognostic (2.39e-1)" "unprognostic (2.69e-3)" "prognostic unfavorable (6.73e-6)" "prognostic unfavorable (4.01e-4)" "unprognostic (2.80e-1)" "prognostic favorable (2.39e-5)" "prognostic unfavorable (3.65e-4)" "unprognostic (3.31e-2)" "prognostic unfavorable (3.12e-5)" "unprognostic (3.52e-2)" "unprognostic (1.67e-1)" "unprognostic (1.98e-2)" "unprognostic (1.00e-2)" 140.7 103.2 95.0 233.2 104.1 590.1 97.1 83.3 116.2 94.9 73.3 199.0 163.5 69.6 73.4 287.4 100.6 136.1 318.5 104.8 101.5 81.5 114.4 178.7 287.3 96.6 101.4 45.4 265.9 91.7 19.6 141.1 101.6 122.3 201.5 60.3 101.5 56.0 8905.8 103.0 167.8 111.6 94.6 208.9 152.8 64.8 93.8 203.0 88.8 6106.5 287.2 183.2 29.7 98.2 529.4 332.8 306.1 225.4 262.1 341.1 317.9 439.0 419.1 597.9 437.7 596.1 513.9 414.6 366.9 500.2 206.4 472.1 320.0 468.7 485.8 315.7 171.9 537.6 234.1 311.7 200.9 728.2 627.5 260.0 246.2 515.8 355.1 224.9 929.4 269.0 411.8 429.7 710.0 342.2 582.0 683.1 714.2 775.9 515.9 510.0 233.2 574.9 405.6 387.4 234.4 409.4 360.0 443.7 419.2 303.9 645.0 788.9 758.8 558.8 353.9 497.3 711.1 332.4 623.0 516.2 490.7 514.7 860.0 932.1 743.2 1729.3 547.2 945.6 480.1 395.2 464.0 504.4 792.6 324.5 347.2 442.6 824.3 386.4 1104.4 392.9 551.5 2029.4 95.0 104.1 83.3 116.2 104.8 101.5 96.6 101.4 101.6 94.6 93.8 98.2 346.0 621.8 343.2 17.6 318.6 149.5 227.6 169.5 127.5 84.2 135.4 88.4 85.0 125.8 275.6 97.5 31.3 127.3 475.7 494.5 105.7 292.1 72.3 353.7 191.1 395.7 141.0 189.8 65.7 347.0 331.0 170.4 245.6 474.2 531.3 119.5 200.3 110.6 559.1 304.5 50.5 291.2 93.6 355.6 504.7 182.3 46.6 648.3 152.9 31.9 704.0 54.5 466.5 12.5 30.6 530.4 363.9 29.7 218.2 204.8 220.1 179.8 230.8 62.8 19.7 155.1 128.5 38.6 67.6 223.6 143.3 101.9 422.6 119.2 302.1 324.6 TPR ENSG00000047410 "Translocated promoter region, nuclear basket protein" P12270 1 186311652-186375693 "Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Cell cycle, Cell division, Mitosis, mRNA transport, Protein transport, Translocation, Transport" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 772.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019661, HPA019663, HPA024336" Enhanced Enhanced "Nuclear membrane" NA NA 30000000 "Cluster 6: Non-specific - Transcription" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "Nuclear membrane" "HPA019661: AB_1858215, HPA019663: AB_1858216, HPA024336: AB_1858217" "unprognostic (4.51e-2)" "unprognostic (9.87e-3)" "unprognostic (2.48e-1)" "unprognostic (7.56e-2)" "unprognostic (9.88e-3)" "prognostic favorable (4.71e-4)" "prognostic unfavorable (1.06e-4)" "unprognostic (1.71e-1)" "unprognostic (3.71e-2)" "unprognostic (1.14e-1)" "unprognostic (1.45e-2)" "unprognostic (3.63e-2)" "unprognostic (1.31e-3)" "unprognostic (3.75e-1)" "unprognostic (4.19e-2)" "unprognostic (5.06e-2)" "unprognostic (1.98e-2)" 19.8 14.5 12.2 23.4 14.1 28.9 19.7 14.4 10.9 17.6 18.4 17.6 15.5 20.3 19.7 14.8 15.0 16.1 17.1 9.5 12.9 16.0 15.4 18.0 26.0 13.6 12.0 23.1 15.5 34.2 13.4 26.7 13.8 17.2 20.0 19.8 15.8 17.6 20.4 24.2 19.3 17.6 12.2 22.9 19.1 43.8 13.3 31.0 22.7 22.3 26.0 19.6 14.5 15.1 55.9 46.7 68.2 39.8 53.4 47.4 73.2 62.0 41.2 42.8 40.4 70.5 45.9 64.0 47.1 42.1 29.4 70.9 51.9 42.4 52.1 51.8 58.6 86.8 78.3 49.7 28.7 93.1 53.5 36.4 25.0 64.4 49.4 39.3 51.3 36.5 106.0 57.3 45.8 47.5 46.2 24.5 76.1 49.9 16.0 54.3 54.3 56.5 34.8 65.0 37.7 59.5 72.9 47.1 37.6 92.5 53.1 58.0 73.0 42.5 40.6 47.7 76.6 63.2 77.6 57.0 27.5 45.8 38.7 121.4 34.1 69.0 43.8 30.0 37.7 48.9 38.6 36.8 20.6 55.4 47.3 32.8 145.7 33.0 50.4 58.7 49.1 17.3 12.2 14.1 14.4 10.9 9.5 12.9 13.6 12.0 13.8 12.2 13.3 15.1 126.4 218.0 119.6 43.1 122.9 101.2 105.5 98.6 114.9 89.8 65.8 79.8 180.0 54.3 110.0 58.8 79.2 136.9 136.8 51.2 23.5 107.1 199.3 129.1 151.7 123.8 67.7 102.4 42.5 74.7 99.9 126.5 80.5 134.4 81.0 134.2 74.6 40.8 72.8 99.3 42.6 61.9 93.6 64.2 79.3 50.4 125.6 92.6 55.2 39.4 137.3 101.1 139.0 48.2 62.8 90.1 56.7 117.4 113.7 95.1 52.4 27.7 120.9 111.4 131.5 172.5 152.1 772.9 250.4 85.6 99.2 150.8 145.8 160.0 77.7 96.0 TRAF7 "DKFZp586I021, MGC7807, RFWD1, RNF119" ENSG00000131653 "TNF receptor associated factor 7" Q6Q0C0 16 2155698-2178129 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Transcription, Transcription regulation, Ubl conjugation pathway" Transferase "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041229 Approved Supported "Vesicles,Plasma membrane" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 7: Non-specific - Mitochondria" Vesicles "Plasma membrane" "HPA041229: AB_10794194" "unprognostic (1.94e-1)" "unprognostic (5.97e-2)" "unprognostic (1.13e-1)" "unprognostic (4.23e-2)" "unprognostic (1.09e-1)" "unprognostic (1.03e-1)" "unprognostic (1.65e-2)" "unprognostic (2.77e-3)" "unprognostic (7.08e-2)" "unprognostic (3.52e-2)" "unprognostic (1.52e-2)" "unprognostic (1.08e-1)" "unprognostic (9.23e-2)" "unprognostic (6.07e-2)" "unprognostic (2.99e-2)" "unprognostic (2.43e-1)" "unprognostic (8.48e-2)" 29.1 29.4 16.5 24.4 15.1 35.0 28.2 18.2 23.0 32.1 17.0 38.0 40.0 31.2 11.6 54.6 30.4 22.2 21.3 17.9 14.6 28.1 51.5 33.2 22.9 17.8 15.3 23.5 37.4 14.6 32.1 20.6 14.8 27.0 17.4 8.5 34.7 16.5 30.4 47.7 35.2 18.8 14.2 34.5 35.6 14.8 17.7 19.1 25.6 9.9 18.6 34.5 34.8 14.3 57.7 72.2 40.3 72.5 40.8 76.5 47.4 43.4 53.9 49.9 44.6 88.2 72.1 36.6 50.2 55.4 31.8 65.9 38.1 76.8 18.8 58.3 48.8 52.4 98.5 68.3 53.8 56.3 72.7 76.2 62.8 48.1 62.6 41.0 97.4 70.6 57.1 47.9 48.2 131.1 58.3 65.2 79.7 78.7 34.8 107.4 66.7 74.2 40.2 30.4 80.9 67.2 36.3 68.5 48.6 20.9 78.1 68.2 74.3 60.2 83.9 56.7 48.2 69.2 55.0 48.4 34.4 35.9 47.8 4.0 9.1 7.3 4.5 12.4 4.3 5.5 4.4 4.7 11.2 3.9 3.1 3.8 6.2 2.9 8.9 5.3 6.5 5.3 16.5 15.1 18.2 23.0 17.9 14.6 17.8 15.3 14.8 14.2 17.7 14.3 18.9 0.0 9.2 12.4 18.2 28.8 21.1 34.2 22.8 15.9 31.6 27.9 4.9 21.5 20.8 14.7 6.2 23.5 17.4 56.4 17.6 39.0 5.0 23.6 34.6 26.5 34.0 33.6 8.9 59.0 36.3 19.0 38.7 27.9 9.5 22.1 26.0 32.3 42.2 37.0 8.2 38.7 34.6 41.8 21.3 13.1 24.8 26.8 10.6 8.4 33.9 12.6 6.2 6.6 4.9 53.0 43.6 22.2 24.0 33.8 80.0 29.2 19.7 10.9 6.6 11.9 18.3 8.5 25.3 50.7 32.5 26.7 16.0 29.0 42.5 38.5 TSPAN31 SAS ENSG00000135452 "Tetraspanin 31" Q12999 12 57738013-57750219 "Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Cancer enriched" "Detected in all" 4 "glioma: 54.2" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RH-30: 139.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030758, HPA057489" Approved Approved "Nucleoplasm,Golgi apparatus,Cytokinetic bridge,Cytosol" Yes No "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 1: Thyroid gland - Transcription" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 5: Muller glia cells - Visual perception" "Golgi apparatus" "Nucleoplasm, Cytokinetic bridge, Cytosol" "HPA030758: , HPA057489: AB_2683447" "unprognostic (2.66e-2)" "unprognostic (1.50e-1)" "unprognostic (1.91e-1)" "unprognostic (1.82e-1)" "unprognostic (8.96e-3)" "prognostic unfavorable (1.09e-4)" "unprognostic (4.31e-3)" "unprognostic (1.19e-1)" "unprognostic (6.51e-3)" "unprognostic (5.31e-2)" "unprognostic (2.68e-1)" "unprognostic (2.79e-1)" "prognostic favorable (9.91e-5)" "unprognostic (1.68e-1)" "unprognostic (1.59e-1)" "unprognostic (6.32e-2)" "unprognostic (1.58e-1)" 24.5 29.7 9.0 11.2 10.8 5.5 23.1 10.8 15.6 26.2 11.8 20.5 16.4 26.2 13.2 20.4 25.8 20.9 26.7 9.5 10.3 26.7 20.9 22.8 11.8 11.2 10.2 25.6 25.2 32.7 24.4 12.5 11.0 22.1 10.7 29.7 25.6 13.5 21.0 18.6 18.5 8.4 11.1 20.8 23.0 8.0 9.9 9.8 30.2 21.2 8.7 21.0 20.1 13.0 9.5 23.4 21.1 5.4 44.3 24.0 13.5 15.8 11.7 4.6 5.1 16.7 46.4 7.6 32.7 29.0 9.4 17.5 5.7 26.7 10.7 23.1 15.4 10.7 18.7 6.6 45.2 10.6 17.9 29.6 30.2 13.7 30.3 22.1 14.6 4.6 7.5 19.9 19.6 19.4 9.2 5.9 4.3 18.3 7.0 10.5 139.8 20.0 15.7 19.0 6.6 16.7 15.6 21.3 10.5 4.5 41.1 15.8 27.6 11.3 9.5 5.6 7.4 28.9 8.1 4.1 32.7 6.3 19.2 25.4 26.3 16.4 35.8 28.6 34.8 31.1 28.5 30.7 27.6 31.0 28.3 26.2 5.8 35.4 42.0 58.3 22.1 33.0 9.0 10.8 10.8 15.6 9.5 10.3 11.2 10.2 11.0 11.1 9.9 13.0 37.1 48.1 32.4 8.1 23.8 11.2 46.4 37.4 22.2 43.2 32.0 27.4 5.1 20.0 31.4 31.3 41.7 20.9 29.8 19.9 9.8 37.6 1.2 18.5 32.5 26.7 26.5 8.2 9.1 39.0 15.2 31.7 11.7 20.4 45.0 28.9 22.1 21.6 22.4 21.9 9.1 21.6 32.6 18.0 16.4 1.8 25.7 24.2 32.0 8.4 21.6 62.7 35.0 11.1 13.3 37.6 20.3 17.3 18.4 30.5 30.6 18.1 27.9 60.4 19.7 22.3 31.9 9.2 7.7 16.1 12.6 24.5 20.4 35.3 19.4 31.8 U2AF1 "RN, RNU2AF1, U2AF35, U2AFBP" ENSG00000160201 "U2 small nuclear RNA auxiliary factor 1" Q01081 21 43092956-43107570 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "mRNA processing, mRNA splicing" RNA-binding "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Basal keratinocytes: 492.9;Basal respiratory cells: 406.9;Ionocytes: 266.5;Langerhans cells: 374.7;Suprabasal keratinocytes: 433.6" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HEL: 607.7" "Low region specificity" "Detected in all" "HPA044833, HPA052083" Supported Enhanced Nucleoplasm NA NA "Cluster 42: Non-specific - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 36: HEL - Hemostasis" "Cluster 48: Smooth muscle cells - ECM organization" Nucleoplasm "HPA044833: AB_10960990, HPA052083: AB_2681720" "unprognostic (1.10e-1)" "unprognostic (1.28e-1)" "unprognostic (5.98e-2)" "unprognostic (2.87e-2)" "unprognostic (1.36e-1)" "unprognostic (8.06e-2)" "unprognostic (2.76e-2)" "unprognostic (4.29e-4)" "unprognostic (4.81e-4)" "unprognostic (3.42e-2)" "unprognostic (2.31e-3)" "unprognostic (8.85e-2)" "unprognostic (2.14e-6)" "unprognostic (1.08e-1)" "unprognostic (1.40e-2)" "unprognostic (1.72e-1)" "unprognostic (1.26e-2)" 62.9 47.6 36.8 31.1 39.9 85.9 58.7 39.8 46.9 57.6 38.0 79.3 25.8 68.9 27.8 64.3 60.8 18.7 43.0 37.7 41.1 42.8 48.0 57.3 45.2 39.3 40.2 69.3 41.8 32.7 60.1 34.6 38.5 48.0 26.8 28.9 49.1 40.8 74.9 47.5 57.2 35.8 38.3 65.4 58.2 54.4 38.8 61.8 62.6 24.8 55.9 60.7 50.7 40.8 101.1 27.7 250.5 71.3 28.7 38.8 248.1 88.2 82.4 105.4 115.3 486.0 59.8 20.8 35.1 54.3 125.6 33.0 161.1 36.3 104.9 114.6 134.0 607.7 61.2 117.9 77.0 264.0 115.2 45.5 90.6 177.1 100.6 43.5 62.8 238.0 105.8 113.4 97.2 324.4 271.1 358.1 287.6 123.4 108.3 485.1 166.9 211.9 99.8 15.4 125.9 77.6 212.6 98.6 147.6 36.5 125.5 147.5 12.1 79.2 59.6 82.0 236.3 191.4 178.3 48.8 80.3 333.6 118.6 211.9 141.0 153.1 101.2 140.4 106.7 140.2 112.7 95.5 150.4 134.2 112.9 109.1 213.1 93.1 196.9 240.7 149.3 188.7 36.8 39.9 39.8 46.9 37.7 41.1 39.3 40.2 38.5 38.3 38.8 40.8 9.5 19.2 18.1 3.9 37.8 492.9 32.5 406.9 86.6 23.9 5.7 2.8 5.0 17.2 153.5 1.8 43.8 19.5 15.3 16.5 1.9 5.2 3.1 4.2 4.4 51.7 18.2 45.0 5.2 6.0 20.7 51.8 44.4 4.2 28.4 3.8 31.8 16.2 23.2 18.5 4.6 17.0 266.5 33.0 374.7 4.1 18.3 30.6 202.7 4.7 19.3 13.0 27.8 3.0 6.2 4.8 17.0 22.6 60.3 31.1 43.2 3.1 107.6 60.7 6.6 39.1 110.7 16.4 18.9 79.8 433.6 23.8 46.6 1.3 20.2 39.1 VHL VHL1 ENSG00000134086 "Von Hippel-Lindau tumor suppressor" P40337 3 10141778-10153667 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Ubl conjugation pathway" "Cancer-related genes, Congenital erythrocytosis, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "BEWO: 146.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031631, HPA031632, HPA068954" Approved Enhanced Nucleoplasm,Cytosol NA NA "Cluster 17: Basophils - Unknown function" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 28: BEWO - Transcription regulation" "Cluster 57: B-cells - Immune response" Nucleoplasm Cytosol "HPA031631: AB_2673968, HPA031632: AB_2673969, HPA068954: " "prognostic unfavorable (9.02e-5)" "unprognostic (1.10e-1)" "unprognostic (4.46e-3)" "unprognostic (1.52e-1)" "unprognostic (1.10e-1)" "unprognostic (1.33e-1)" "prognostic unfavorable (1.32e-5)" "unprognostic (3.55e-1)" "unprognostic (3.03e-2)" "unprognostic (4.36e-2)" "unprognostic (5.82e-3)" "unprognostic (1.81e-2)" "unprognostic (2.51e-1)" "prognostic favorable (7.84e-4)" "unprognostic (1.46e-1)" "unprognostic (2.92e-2)" "unprognostic (1.28e-3)" 14.0 13.7 11.5 21.1 11.0 27.9 14.7 13.6 12.1 11.8 6.7 14.8 15.7 14.1 9.8 12.3 13.4 11.5 7.9 11.8 14.9 12.6 14.1 11.8 29.6 9.4 9.4 12.6 12.7 11.7 9.0 14.1 9.3 14.0 15.7 8.9 14.5 10.2 11.4 14.2 17.2 12.8 9.6 22.5 16.0 13.4 16.6 23.4 15.8 7.7 29.7 12.5 10.9 12.5 19.5 18.2 39.9 24.6 36.0 27.7 146.5 16.8 24.0 21.1 24.5 21.5 23.7 67.9 22.2 23.0 29.9 16.4 37.2 23.6 25.7 33.0 33.7 52.7 30.5 30.6 34.3 47.3 41.3 28.1 26.3 28.0 35.1 28.4 24.6 42.5 48.3 50.3 21.1 35.0 45.5 40.9 26.7 21.1 23.4 57.3 34.6 34.6 25.5 48.7 15.0 49.4 35.0 18.7 21.0 23.9 37.0 59.1 21.3 20.8 27.7 19.6 26.8 35.7 78.1 105.6 23.2 55.3 19.4 4.6 3.2 2.3 2.6 2.2 1.9 2.5 1.8 2.2 2.0 3.3 1.7 1.8 5.6 3.0 2.0 2.3 1.7 1.2 11.5 11.0 13.6 12.1 11.8 14.9 9.4 9.4 9.3 9.6 16.6 12.5 12.4 12.8 12.5 9.1 38.7 14.7 17.8 14.3 24.5 14.7 10.7 6.1 6.1 20.0 9.6 16.5 18.8 16.8 21.9 10.7 7.9 11.8 9.6 13.1 26.1 14.8 14.4 30.5 15.9 5.1 18.7 12.8 20.9 19.9 5.1 18.4 18.9 14.3 14.9 18.5 14.2 11.3 16.2 27.1 45.8 7.3 14.0 32.3 12.4 7.5 31.9 9.1 28.8 12.1 14.9 10.7 11.7 11.3 33.3 23.8 12.3 9.5 9.7 15.3 6.6 17.4 11.9 15.4 24.0 26.7 20.5 17.2 23.5 21.4 10.2 25.9 WT1 "AWT1, GUD, NPHS4, WAGR, WIT-2" ENSG00000184937 "WT1 transcription factor" P19544 11 32387775-32435564 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "DNA-binding, RNA-binding" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "endometrium 1: 67.6;fallopian tube: 52.3;ovary: 45.8" "Cell type enhanced" "Detected in some" "Collecting duct cells: 20.2;Endometrial stromal cells: 70.1;Endothelial cells: 16.3;Granulosa cells: 9.3;Late spermatids: 9.3" "Cancer enriched" "Detected in many" 14 "ovarian cancer: 55.2" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HEL: 20.7;HMC-1: 29.9;K-562: 19.6;NB-4: 37.2;THP-1: 19.6" "Not detected" "Not detected" "Not detected" "Not detected" "CAB000327, HPA035717, HPA053848" Enhanced Enhanced Nucleoplasm NA NA "Cluster 89: Fibroblasts - ECM organization" "Cluster 1: K-562 - Erythropoiesis" "Cluster 36: Stromal cells - Cell proliferation" Nucleoplasm "CAB000327: AB_2304486, HPA035717: AB_2674748, HPA053848: AB_2682279" "unprognostic (3.09e-3)" "unprognostic (9.97e-4)" "unprognostic (3.32e-1)" "unprognostic (8.24e-3)" "unprognostic (5.20e-2)" "unprognostic (1.98e-3)" "unprognostic (2.94e-2)" "unprognostic (1.59e-2)" "unprognostic (1.23e-2)" "unprognostic (4.15e-2)" "unprognostic (1.86e-2)" "unprognostic (1.36e-1)" "unprognostic (1.31e-10)" "unprognostic (2.65e-3)" "unprognostic (1.87e-1)" "unprognostic (1.96e-3)" "unprognostic (1.30e-2)" 26.5 0.2 0.0 0.5 0.1 0.0 0.1 0.0 0.1 18.4 0.0 0.7 0.0 67.6 5.3 0.0 52.3 1.3 4.5 0.1 0.0 16.3 0.1 0.8 0.0 0.2 0.1 45.8 0.1 0.0 0.0 1.3 0.0 0.7 0.0 0.0 0.0 2.9 0.0 0.0 0.1 33.1 0.0 19.0 0.2 24.2 0.0 0.0 0.0 0.0 0.0 0.2 8.4 0.0 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.9 0.0 0.0 0.1 0.0 0.0 0.0 8.1 0.0 0.0 0.0 8.4 20.7 0.0 1.2 4.7 10.8 29.9 0.0 0.0 3.4 0.0 0.0 0.0 0.7 19.6 0.0 2.0 0.0 11.2 37.2 0.8 0.0 6.3 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.9 2.1 19.6 0.2 0.0 3.3 0.0 0.3 0.0 0.0 0.0 0.0 0.9 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 20.2 0.0 1.0 0.0 0.0 0.0 0.0 3.6 2.2 70.1 16.3 0.0 0.0 0.1 0.0 0.5 7.3 0.0 1.4 0.0 9.3 1.4 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 9.3 8.4 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.2 0.0 0.1 0.0 2.3 0.0 0.0 6.6 0.0 2.0 4.5 1.0 0.0 0.0 0.8 0.5 0.4 0.0 0.1 ZBTB16 "PLZF, ZNF145" ENSG00000109906 "Zinc finger and BTB domain containing 16" Q05516 11 114059711-114256765 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation, Ubl conjugation pathway" "DNA-binding, Repressor" "Cancer-related genes, Disease variant, Mental retardation, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "tongue: 105.8" "Cell type enhanced" "Detected in many" "Excitatory neurons: 134.8;Inhibitory neurons: 125.9;NK-cells: 119.4;Skeletal myocytes: 163.9" "Cancer enhanced" "Detected in many" "prostate cancer: 5.2" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "gdT-cell: 23.3;MAIT T-cell: 39.4;naive B-cell: 11.0;NK-cell: 10.9" "Group enriched" "Detected in many" 5 "B-cells: 11.0;NK-cells: 10.9;T-cells: 39.4" "Cell line enhanced" "Detected in some" "ASC diff: 71.5;ASC TERT1: 38.6;HEL: 40.7;HHSteC: 26.6;HSkMC: 26.7;hTCEpi: 30.6;hTERT-HME1: 25.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001499, CAB004540" Uncertain NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "CAB004540: AB_2218941, HPA001499: AB_1079640" "unprognostic (2.21e-1)" "unprognostic (2.17e-1)" "unprognostic (7.30e-2)" "unprognostic (1.18e-1)" "unprognostic (2.53e-1)" "unprognostic (3.05e-1)" "unprognostic (1.25e-2)" "unprognostic (1.40e-1)" "unprognostic (1.09e-1)" "unprognostic (8.79e-4)" "unprognostic (1.68e-1)" "unprognostic (1.18e-1)" "prognostic favorable (2.21e-4)" "unprognostic (2.57e-3)" "unprognostic (2.67e-1)" "unprognostic (1.00e-1)" "unprognostic (5.90e-2)" 55.8 20.8 5.1 3.4 14.9 7.6 32.3 11.7 24.8 25.9 17.7 20.9 0.9 29.6 4.0 28.1 30.9 13.1 28.1 9.9 8.4 10.6 14.5 27.1 8.8 20.1 8.4 51.4 61.7 34.3 6.4 9.6 15.2 15.1 3.3 2.2 13.3 7.0 88.6 28.5 16.3 15.8 4.9 13.2 18.3 4.0 7.1 6.5 29.3 105.8 2.0 29.4 19.7 18.0 0.0 0.0 13.0 0.0 71.5 38.6 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.5 40.7 0.0 0.0 26.6 0.9 0.7 26.7 30.6 0.0 25.6 0.0 4.6 5.5 0.1 0.0 0.8 0.0 2.2 9.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.0 8.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 4.2 1.2 23.3 1.2 39.4 0.4 1.2 3.5 0.1 11.0 1.3 0.6 0.3 10.9 1.2 0.0 0.4 5.7 5.1 14.9 11.7 24.8 9.9 8.4 20.1 8.4 15.2 4.9 7.1 18.0 95.3 22.4 7.7 59.1 16.3 11.1 81.7 7.7 8.6 32.6 12.6 16.8 35.1 42.9 7.1 9.2 0.0 0.1 51.2 0.7 1.9 1.9 21.1 1.7 41.3 49.5 7.2 18.1 134.8 0.9 0.2 59.8 1.1 3.8 14.5 38.2 65.7 50.9 0.8 0.0 125.9 3.7 8.2 27.0 5.3 27.7 89.8 32.1 7.2 65.6 7.6 20.2 119.4 45.8 43.4 0.3 0.1 92.2 17.7 38.6 28.8 6.6 6.8 1.9 105.2 163.9 75.3 0.4 9.9 1.8 6.8 0.3 27.8 0.2 3.5 9.4 ZRSR2 "U2AF1-RS2, U2AF1L2, URP, ZC3H22" ENSG00000169249 "Zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2" Q15696 X 15790472-15823260 "Cancer-related genes, Human disease related genes, Predicted intracellular proteins" "mRNA processing, mRNA splicing" "Ribonucleoprotein, RNA-binding" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" "prognostic favorable (7.96e-4)" "unprognostic (1.54e-2)" "unprognostic (7.31e-2)" "prognostic favorable (8.50e-5)" "unprognostic (8.08e-2)" "unprognostic (1.69e-1)" "unprognostic (6.14e-3)" "unprognostic (5.72e-3)" "unprognostic (8.46e-2)" "unprognostic (3.47e-3)" "unprognostic (6.90e-2)" "unprognostic (2.85e-2)" "prognostic unfavorable (4.87e-5)" "unprognostic (8.14e-2)" "unprognostic (3.04e-1)" "unprognostic (1.65e-2)" "prognostic favorable (2.97e-4)" 15.2 12.1 25.7 17.3 25.1 42.7 16.2 28.8 36.1 24.3 26.5 22.9 11.0 21.3 20.2 13.4 20.2 10.2 17.2 24.4 27.5 16.2 13.3 20.1 29.0 25.9 24.9 22.2 14.3 13.0 24.1 10.8 24.9 18.1 12.5 22.2 13.9 11.9 20.4 15.4 19.8 17.0 23.2 31.8 14.8 5.6 26.0 21.9 17.4 13.1 20.2 18.1 20.1 26.3 14.3 8.9 15.6 14.7 21.9 18.4 6.1 11.4 10.5 10.8 11.0 11.3 11.3 16.1 19.2 10.6 28.3 13.7 15.6 19.9 11.0 12.3 20.0 10.4 22.8 10.1 14.8 24.4 23.9 9.2 17.7 20.0 32.4 21.3 18.9 15.5 17.0 15.3 12.9 17.5 13.0 25.4 20.1 7.5 12.7 15.1 22.0 16.4 12.9 11.0 10.6 11.8 26.7 23.5 17.7 21.4 18.4 13.6 13.2 10.7 7.8 28.7 11.0 12.9 11.7 15.0 8.2 17.0 14.2 38.7 25.7 24.0 17.3 22.6 17.2 34.9 21.6 23.2 15.1 37.2 26.1 18.5 26.9 14.3 22.9 24.6 24.3 10.5 25.7 25.1 28.8 36.1 24.4 27.5 25.9 24.9 24.9 23.2 26.0 26.3 16.7 9.6 17.4 12.1 35.6 11.3 10.2 16.6 12.0 15.3 13.8 12.1 23.9 5.7 17.2 16.5 14.6 6.8 42.3 14.0 23.5 12.8 1.1 27.7 14.3 14.2 16.8 9.9 15.5 14.9 10.2 11.5 4.6 14.1 32.3 9.7 11.0 13.8 19.1 8.4 17.9 16.9 22.4 33.5 19.6 1.6 13.7 25.6 12.4 14.0 30.5 9.6 37.0 10.1 13.7 13.1 8.2 16.6 18.8 7.0 17.3 17.7 23.7 19.5 19.7 13.8 16.2 6.4 8.3 7.8 10.5 7.3 32.2 9.3 13.4 8.0