Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific nTPM" "RNA single cell type specificity" "RNA single cell type distribution" "RNA single cell type specificity score" "RNA single cell type specific nTPM" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific nTPM" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific nTPM" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific nTPM" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific nTPM" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific nTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific nTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "CCD Protein" "CCD Transcript" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Blood expression cluster" "Tissue expression cluster" "Cell line expression cluster" "Single cell expression cluster" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [nTPM]" "Tissue RNA - adrenal gland [nTPM]" "Tissue RNA - amygdala [nTPM]" "Tissue RNA - appendix [nTPM]" "Tissue RNA - basal ganglia [nTPM]" "Tissue RNA - bone marrow [nTPM]" "Tissue RNA - breast [nTPM]" "Tissue RNA - cerebellum [nTPM]" "Tissue RNA - cerebral cortex [nTPM]" "Tissue RNA - cervix [nTPM]" "Tissue RNA - choroid plexus [nTPM]" "Tissue RNA - colon [nTPM]" "Tissue RNA - duodenum [nTPM]" "Tissue RNA - endometrium 1 [nTPM]" "Tissue RNA - epididymis [nTPM]" "Tissue RNA - esophagus [nTPM]" "Tissue RNA - fallopian tube [nTPM]" "Tissue RNA - gallbladder [nTPM]" "Tissue RNA - heart muscle [nTPM]" "Tissue RNA - hippocampal formation [nTPM]" "Tissue RNA - hypothalamus [nTPM]" "Tissue RNA - kidney [nTPM]" "Tissue RNA - liver [nTPM]" "Tissue RNA - lung [nTPM]" "Tissue RNA - lymph node [nTPM]" "Tissue RNA - medulla oblongata [nTPM]" "Tissue RNA - midbrain [nTPM]" "Tissue RNA - ovary [nTPM]" "Tissue RNA - pancreas [nTPM]" "Tissue RNA - parathyroid gland [nTPM]" "Tissue RNA - pituitary gland [nTPM]" "Tissue RNA - placenta [nTPM]" "Tissue RNA - pons [nTPM]" "Tissue RNA - prostate [nTPM]" "Tissue RNA - rectum [nTPM]" "Tissue RNA - retina [nTPM]" "Tissue RNA - salivary gland [nTPM]" "Tissue RNA - seminal vesicle [nTPM]" "Tissue RNA - skeletal muscle [nTPM]" "Tissue RNA - skin 1 [nTPM]" "Tissue RNA - small intestine [nTPM]" "Tissue RNA - smooth muscle [nTPM]" "Tissue RNA - spinal cord [nTPM]" "Tissue RNA - spleen [nTPM]" "Tissue RNA - stomach 1 [nTPM]" "Tissue RNA - testis [nTPM]" "Tissue RNA - thalamus [nTPM]" "Tissue RNA - thymus [nTPM]" "Tissue RNA - thyroid gland [nTPM]" "Tissue RNA - tongue [nTPM]" "Tissue RNA - tonsil [nTPM]" "Tissue RNA - urinary bladder [nTPM]" "Tissue RNA - vagina [nTPM]" "Tissue RNA - white matter [nTPM]" "Cell RNA - A-431 [nTPM]" "Cell RNA - A549 [nTPM]" "Cell RNA - AF22 [nTPM]" "Cell RNA - AN3-CA [nTPM]" "Cell RNA - ASC diff [nTPM]" "Cell RNA - ASC TERT1 [nTPM]" "Cell RNA - BEWO [nTPM]" "Cell RNA - BJ [nTPM]" "Cell RNA - BJ hTERT+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]" "Cell RNA - CACO-2 [nTPM]" "Cell RNA - CAPAN-2 [nTPM]" "Cell RNA - Daudi [nTPM]" "Cell RNA - EFO-21 [nTPM]" "Cell RNA - fHDF/TERT166 [nTPM]" "Cell RNA - GAMG [nTPM]" "Cell RNA - HaCaT [nTPM]" "Cell RNA - HAP1 [nTPM]" "Cell RNA - HBEC3-KT [nTPM]" "Cell RNA - HBF TERT88 [nTPM]" "Cell RNA - HDLM-2 [nTPM]" "Cell RNA - HEK 293 [nTPM]" "Cell RNA - HEL [nTPM]" "Cell RNA - HeLa [nTPM]" "Cell RNA - Hep G2 [nTPM]" "Cell RNA - HHSteC [nTPM]" "Cell RNA - HL-60 [nTPM]" "Cell RNA - HMC-1 [nTPM]" "Cell RNA - HSkMC [nTPM]" "Cell RNA - hTCEpi [nTPM]" "Cell RNA - hTEC/SVTERT24-B [nTPM]" "Cell RNA - hTERT-HME1 [nTPM]" "Cell RNA - hTERT-RPE1 [nTPM]" "Cell RNA - HUVEC TERT2 [nTPM]" "Cell RNA - JURKAT [nTPM]" "Cell RNA - K-562 [nTPM]" "Cell RNA - Karpas-707 [nTPM]" "Cell RNA - LHCN-M2 [nTPM]" "Cell RNA - MCF7 [nTPM]" "Cell RNA - MOLT-4 [nTPM]" "Cell RNA - NB-4 [nTPM]" "Cell RNA - NTERA-2 [nTPM]" "Cell RNA - OE19 [nTPM]" "Cell RNA - PC-3 [nTPM]" "Cell RNA - REH [nTPM]" "Cell RNA - RH-30 [nTPM]" "Cell RNA - RPMI-8226 [nTPM]" "Cell RNA - RPTEC TERT1 [nTPM]" "Cell RNA - RT4 [nTPM]" "Cell RNA - SCLC-21H [nTPM]" "Cell RNA - SH-SY5Y [nTPM]" "Cell RNA - SiHa [nTPM]" "Cell RNA - SK-BR-3 [nTPM]" "Cell RNA - SK-MEL-30 [nTPM]" "Cell RNA - SuSa [nTPM]" "Cell RNA - T-47d [nTPM]" "Cell RNA - THP-1 [nTPM]" "Cell RNA - TIME [nTPM]" "Cell RNA - U-138 MG [nTPM]" "Cell RNA - U-2 OS [nTPM]" "Cell RNA - U-2197 [nTPM]" "Cell RNA - U-251 MG [nTPM]" "Cell RNA - U-266/70 [nTPM]" "Cell RNA - U-266/84 [nTPM]" "Cell RNA - U-698 [nTPM]" "Cell RNA - U-87 MG [nTPM]" "Cell RNA - U-937 [nTPM]" "Cell RNA - WM-115 [nTPM]" "Blood RNA - basophil [nTPM]" "Blood RNA - classical monocyte [nTPM]" "Blood RNA - eosinophil [nTPM]" "Blood RNA - gdT-cell [nTPM]" "Blood RNA - intermediate monocyte [nTPM]" "Blood RNA - MAIT T-cell [nTPM]" "Blood RNA - memory B-cell [nTPM]" "Blood RNA - memory CD4 T-cell [nTPM]" "Blood RNA - memory CD8 T-cell [nTPM]" "Blood RNA - myeloid DC [nTPM]" "Blood RNA - naive B-cell [nTPM]" "Blood RNA - naive CD4 T-cell [nTPM]" "Blood RNA - naive CD8 T-cell [nTPM]" "Blood RNA - neutrophil [nTPM]" "Blood RNA - NK-cell [nTPM]" "Blood RNA - non-classical monocyte [nTPM]" "Blood RNA - plasmacytoid DC [nTPM]" "Blood RNA - T-reg [nTPM]" "Blood RNA - total PBMC [nTPM]" "Brain RNA - amygdala [nTPM]" "Brain RNA - basal ganglia [nTPM]" "Brain RNA - cerebellum [nTPM]" "Brain RNA - cerebral cortex [nTPM]" "Brain RNA - hippocampal formation [nTPM]" "Brain RNA - hypothalamus [nTPM]" "Brain RNA - medulla oblongata [nTPM]" "Brain RNA - midbrain [nTPM]" "Brain RNA - pons [nTPM]" "Brain RNA - spinal cord [nTPM]" "Brain RNA - thalamus [nTPM]" "Brain RNA - white matter [nTPM]" "Single Cell Type RNA - Adipocytes [nTPM]" "Single Cell Type RNA - Alveolar cells type 1 [nTPM]" "Single Cell Type RNA - Alveolar cells type 2 [nTPM]" "Single Cell Type RNA - Astrocytes [nTPM]" "Single Cell Type RNA - B-cells [nTPM]" "Single Cell Type RNA - Basal keratinocytes [nTPM]" "Single Cell Type RNA - Basal prostatic cells [nTPM]" "Single Cell Type RNA - Basal respiratory cells [nTPM]" "Single Cell Type RNA - Basal squamous epithelial cells [nTPM]" "Single Cell Type RNA - Bipolar cells [nTPM]" "Single Cell Type RNA - Breast glandular cells [nTPM]" "Single Cell Type RNA - Breast myoepithelial cells [nTPM]" "Single Cell Type RNA - Cardiomyocytes [nTPM]" "Single Cell Type RNA - Cholangiocytes [nTPM]" "Single Cell Type RNA - Club cells [nTPM]" "Single Cell Type RNA - Collecting duct cells [nTPM]" "Single Cell Type RNA - Cone photoreceptor cells [nTPM]" "Single Cell Type RNA - Cytotrophoblasts [nTPM]" "Single Cell Type RNA - dendritic cells [nTPM]" "Single Cell Type RNA - Distal enterocytes [nTPM]" "Single Cell Type RNA - Distal tubular cells [nTPM]" "Single Cell Type RNA - Ductal cells [nTPM]" "Single Cell Type RNA - Early spermatids [nTPM]" "Single Cell Type RNA - Endometrial ciliated cells [nTPM]" "Single Cell Type RNA - Endometrial stromal cells [nTPM]" "Single Cell Type RNA - Endothelial cells [nTPM]" "Single Cell Type RNA - Enteroendocrine cells [nTPM]" "Single Cell Type RNA - Erythroid cells [nTPM]" "Single Cell Type RNA - Excitatory neurons [nTPM]" "Single Cell Type RNA - Exocrine glandular cells [nTPM]" "Single Cell Type RNA - Extravillous trophoblasts [nTPM]" "Single Cell Type RNA - Fibroblasts [nTPM]" "Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]" "Single Cell Type RNA - Glandular and luminal cells [nTPM]" "Single Cell Type RNA - granulocytes [nTPM]" "Single Cell Type RNA - Granulosa cells [nTPM]" "Single Cell Type RNA - Hepatic stellate cells [nTPM]" "Single Cell Type RNA - Hepatocytes [nTPM]" "Single Cell Type RNA - Hofbauer cells [nTPM]" "Single Cell Type RNA - Horizontal cells [nTPM]" "Single Cell Type RNA - Inhibitory neurons [nTPM]" "Single Cell Type RNA - Intestinal goblet cells [nTPM]" "Single Cell Type RNA - Ionocytes [nTPM]" "Single Cell Type RNA - Kupffer cells [nTPM]" "Single Cell Type RNA - Langerhans cells [nTPM]" "Single Cell Type RNA - Late spermatids [nTPM]" "Single Cell Type RNA - Leydig cells [nTPM]" "Single Cell Type RNA - Macrophages [nTPM]" "Single Cell Type RNA - Melanocytes [nTPM]" "Single Cell Type RNA - Microglial cells [nTPM]" "Single Cell Type RNA - monocytes [nTPM]" "Single Cell Type RNA - Muller glia cells [nTPM]" "Single Cell Type RNA - NK-cells [nTPM]" "Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]" "Single Cell Type RNA - Oligodendrocytes [nTPM]" "Single Cell Type RNA - Pancreatic endocrine cells [nTPM]" "Single Cell Type RNA - Paneth cells [nTPM]" "Single Cell Type RNA - Peritubular cells [nTPM]" "Single Cell Type RNA - Plasma cells [nTPM]" "Single Cell Type RNA - Prostatic glandular cells [nTPM]" "Single Cell Type RNA - Proximal enterocytes [nTPM]" "Single Cell Type RNA - Proximal tubular cells [nTPM]" "Single Cell Type RNA - Respiratory ciliated cells [nTPM]" "Single Cell Type RNA - Rod photoreceptor cells [nTPM]" "Single Cell Type RNA - Sertoli cells [nTPM]" "Single Cell Type RNA - Skeletal myocytes [nTPM]" "Single Cell Type RNA - Smooth muscle cells [nTPM]" "Single Cell Type RNA - Spermatocytes [nTPM]" "Single Cell Type RNA - Spermatogonia [nTPM]" "Single Cell Type RNA - Squamous epithelial cells [nTPM]" "Single Cell Type RNA - Suprabasal keratinocytes [nTPM]" "Single Cell Type RNA - Syncytiotrophoblasts [nTPM]" "Single Cell Type RNA - T-cells [nTPM]" "Single Cell Type RNA - Theca cells [nTPM]" "Single Cell Type RNA - Undifferentiated cells [nTPM]" "Single Cell Type RNA - Urothelial cells [nTPM]" ADGB "C6orf103, CAPN16, dJ408K24.1, FLJ23121" ENSG00000118492 Androglobin Q8N7X0 6 146598967-146815462 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 5.5;choroid plexus: 6.0;fallopian tube: 7.5;testis: 26.1" "Cell type enhanced" "Detected in some" "Early spermatids: 305.4;Endometrial ciliated cells: 57.1;Late spermatids: 74.8;Respiratory ciliated cells: 92.5;Spermatocytes: 68.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 18 "HDLM-2: 7.0" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA036340, HPA036341" Enhanced Uncertain Nucleoplasm,Mitochondria No NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 49: Ciliated cells - Cilium organization" "Cluster 44: HDLM-2 - Immune response" "Cluster 49: Ciliated cells - Cilium organization" Mitochondria Nucleoplasm "HPA036340: AB_2675071, HPA036341: AB_10672241" "unprognostic (4.15e-3)" "unprognostic (1.23e-2)" "unprognostic (9.30e-3)" "unprognostic (1.09e-1)" "unprognostic (2.07e-2)" "unprognostic (3.11e-2)" "unprognostic (5.05e-1)" "unprognostic (2.34e-1)" "unprognostic (4.83e-3)" "unprognostic (1.05e-1)" "unprognostic (1.93e-1)" "unprognostic (1.77e-2)" "unprognostic (3.66e-2)" "unprognostic (2.68e-1)" 0.0 0.0 0.8 0.0 0.5 0.0 0.0 0.3 0.1 0.4 6.0 0.3 0.0 0.1 0.2 0.0 7.5 0.0 0.0 0.8 0.8 0.0 0.0 1.4 0.0 5.5 3.8 0.0 0.0 0.0 0.3 0.0 2.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 26.1 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.5 0.3 0.1 0.8 0.8 5.5 3.8 2.4 3.0 1.0 1.0 0.0 3.2 1.5 0.7 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.7 0.0 9.5 0.0 4.2 0.0 0.0 0.4 0.0 0.0 305.4 57.1 0.3 0.1 0.0 0.0 0.8 0.0 0.0 0.1 0.0 0.7 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.4 2.0 0.0 1.9 74.8 2.8 0.4 0.0 1.0 0.0 0.2 0.0 0.5 0.2 0.0 0.3 2.6 0.0 0.1 0.0 0.1 92.5 0.1 0.0 0.0 0.9 68.4 3.3 0.0 0.0 0.0 0.1 0.0 0.7 0.0 ATG4A "APG4A, AUTL2" ENSG00000101844 "Autophagy related 4A cysteine peptidase" Q8WYN0 X 108091668-108154671 "Enzymes, Predicted intracellular proteins" "Autophagy, Protein transport, Transport, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HUVEC TERT2: 84.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036374, HPA064759" Uncertain Approved "Actin filaments,Microtubules" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 6: Erythroid cells - Oxygen transport" Microtubules "Actin filaments" "HPA036374: AB_10672354, HPA064759: AB_2685346" "prognostic unfavorable (1.36e-5)" "unprognostic (1.41e-2)" "unprognostic (3.65e-1)" "unprognostic (2.52e-1)" "unprognostic (1.28e-1)" "unprognostic (1.79e-1)" "unprognostic (1.18e-1)" "unprognostic (2.83e-3)" "unprognostic (2.23e-1)" "unprognostic (3.14e-1)" "unprognostic (2.62e-2)" "unprognostic (4.09e-1)" "unprognostic (1.03e-3)" "unprognostic (7.53e-2)" "unprognostic (2.98e-1)" "unprognostic (5.02e-3)" "unprognostic (1.20e-2)" 8.1 8.5 4.9 7.8 5.2 9.1 7.7 5.2 6.1 7.6 10.4 12.1 12.8 4.7 11.6 8.9 5.6 7.7 11.8 4.7 5.2 14.1 18.1 8.9 8.2 5.3 5.0 2.8 17.2 12.4 6.1 8.0 5.4 5.9 13.1 5.7 13.0 7.1 18.5 5.8 11.4 7.7 5.0 7.7 11.2 2.4 5.7 11.2 11.4 18.6 11.1 8.9 5.1 5.4 13.0 6.5 4.1 7.8 38.2 13.2 5.1 17.5 11.2 9.1 10.6 5.3 6.9 14.0 15.7 14.0 14.5 6.0 11.9 13.0 13.5 24.1 12.9 6.0 10.3 3.7 8.4 13.0 18.8 13.4 13.9 11.1 4.8 8.4 84.9 19.5 18.5 43.5 16.6 12.8 12.1 11.9 7.8 23.6 18.4 8.2 6.9 20.3 13.2 11.3 5.9 4.5 11.2 13.9 7.9 12.4 7.0 11.5 24.0 5.7 2.6 19.1 9.8 20.2 24.0 15.1 11.1 14.6 8.1 28.1 7.8 15.1 11.7 11.3 8.4 9.2 8.9 11.4 10.6 9.9 7.1 12.0 2.4 12.3 7.8 5.4 10.3 8.7 4.9 5.2 5.2 6.1 4.7 5.2 5.3 5.0 5.4 5.0 5.7 5.4 13.6 3.2 10.3 9.1 8.1 5.1 4.9 13.5 2.8 3.2 7.0 4.6 17.4 7.2 12.8 5.5 4.2 6.2 12.4 19.1 27.4 9.6 7.0 10.6 7.4 12.9 6.7 36.7 7.9 17.9 7.5 4.6 8.2 6.0 3.8 3.3 9.7 15.4 9.0 1.7 8.4 9.0 30.5 4.1 3.6 10.0 2.8 7.3 14.2 4.7 6.7 10.3 18.6 7.1 11.6 16.6 8.0 7.5 23.5 5.6 14.7 24.7 17.2 5.0 0.0 4.5 6.9 2.4 3.9 5.9 5.3 10.4 12.0 6.2 5.6 7.3 ATG4B "APG4B, AUTL1, DKFZp586D1822, KIAA0943" ENSG00000168397 "Autophagy related 4B cysteine peptidase" Q9Y4P1 2 241637213-241673857 "Enzymes, Predicted intracellular proteins, Transporters" "Autophagy, Protein transport, Transport, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB037195, HPA069803" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 35: Non-specific - Unknown function" "Cluster 14: REH - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Cytosol" "CAB037195: AB_1078237, HPA069803: AB_2686200" "unprognostic (1.51e-1)" "unprognostic (8.80e-2)" "prognostic unfavorable (6.85e-4)" "unprognostic (1.51e-1)" "unprognostic (2.43e-2)" "unprognostic (2.67e-3)" "unprognostic (1.07e-3)" "unprognostic (1.06e-1)" "unprognostic (1.61e-1)" "unprognostic (1.58e-1)" "unprognostic (1.15e-3)" "unprognostic (3.02e-2)" "prognostic unfavorable (2.79e-4)" "unprognostic (2.60e-1)" "unprognostic (6.63e-2)" "unprognostic (1.66e-1)" "prognostic favorable (9.64e-4)" 12.0 17.5 21.4 8.1 21.7 14.7 13.2 20.9 24.7 18.0 20.1 19.7 11.4 16.8 5.3 16.2 16.8 7.6 18.4 21.6 23.0 19.7 18.0 12.4 13.2 23.0 21.4 16.5 16.4 12.1 21.5 7.2 23.6 22.6 5.4 8.5 14.4 9.6 18.7 16.7 18.3 6.7 20.7 19.9 16.1 19.7 22.4 16.1 18.7 7.6 7.8 16.3 14.6 21.5 8.8 15.6 16.9 13.5 15.8 10.5 29.5 23.8 9.8 16.5 12.4 15.0 9.8 7.4 7.2 11.8 10.5 16.5 16.0 20.3 3.8 18.8 31.8 19.6 14.1 40.2 20.1 13.6 12.0 13.8 15.0 9.0 7.1 16.8 11.0 44.3 23.4 5.1 8.6 32.6 33.4 36.9 30.9 23.8 25.9 51.3 25.1 16.2 11.4 14.9 26.2 21.3 17.5 13.9 27.8 14.1 15.5 24.6 15.4 7.1 12.0 14.8 13.3 21.1 17.0 34.6 18.8 21.4 17.6 3.9 17.9 19.2 18.5 15.6 15.9 15.8 14.2 15.6 20.4 16.5 18.0 12.8 12.8 11.8 18.9 17.0 20.4 16.8 21.4 21.7 20.9 24.7 21.6 23.0 23.0 21.4 23.6 20.7 22.4 21.5 23.2 32.1 33.8 41.1 25.6 24.3 27.2 41.3 25.0 22.2 24.4 21.8 16.2 25.8 29.9 27.6 33.3 35.8 33.5 61.8 19.6 37.5 18.1 28.6 21.9 25.3 35.9 31.8 38.5 40.2 28.5 22.6 40.8 43.3 19.0 36.5 20.3 27.9 33.4 42.1 33.8 36.4 42.7 28.5 34.5 25.9 22.1 30.7 28.4 31.9 51.2 24.5 41.2 20.1 41.0 41.5 41.5 24.8 28.6 35.6 70.5 25.1 26.7 26.8 19.7 22.7 22.8 58.3 63.3 19.9 25.4 53.9 29.4 27.6 35.6 32.5 ATG4C "APG4C, AUTL1, AUTL3, FLJ14867" ENSG00000125703 "Autophagy related 4C cysteine peptidase" Q96DT6 1 62784132-62865516 "Enzymes, Predicted intracellular proteins" "Autophagy, Protein transport, Transport, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 4 "brain: 60.8" "Cell type enriched" "Detected in all" 7 "Oligodendrocytes: 449.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007049 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 70: Brain - Nervous system development" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Nucleoplasm, Cytosol" "HPA007049: AB_1845159" "unprognostic (1.28e-1)" "unprognostic (2.69e-1)" "prognostic favorable (9.83e-4)" "unprognostic (7.43e-2)" "unprognostic (1.17e-1)" "unprognostic (1.70e-1)" "unprognostic (3.76e-2)" "unprognostic (8.36e-2)" "unprognostic (1.83e-2)" "unprognostic (1.30e-1)" "unprognostic (3.77e-1)" "unprognostic (1.93e-1)" "unprognostic (5.66e-2)" "unprognostic (1.81e-1)" "unprognostic (4.17e-2)" "unprognostic (3.26e-2)" "unprognostic (1.19e-1)" 7.9 8.0 23.3 10.3 41.1 5.8 7.8 25.0 24.0 8.5 6.3 8.4 6.7 8.0 5.9 7.2 6.5 8.8 6.0 19.7 25.0 11.2 11.1 8.1 13.3 28.5 29.9 8.3 7.5 10.8 3.3 12.8 29.3 6.5 8.7 6.6 9.8 6.2 5.2 5.5 6.6 9.4 23.7 12.1 7.7 8.1 26.5 13.7 9.9 5.2 10.9 8.3 3.9 60.8 11.5 8.9 13.5 11.9 17.4 18.5 13.5 16.6 11.3 15.7 17.5 6.5 8.8 23.9 12.5 8.5 18.3 8.6 16.1 12.7 22.5 18.0 15.0 27.2 9.3 8.7 12.4 22.2 17.4 15.5 8.9 16.7 7.9 15.1 19.1 26.3 23.4 19.1 13.4 5.4 22.5 8.5 19.8 16.2 14.5 26.5 32.2 17.2 11.2 8.1 18.2 9.1 11.0 20.6 22.1 23.2 10.0 10.3 7.6 12.5 12.2 21.3 18.4 16.3 24.0 20.0 14.3 21.5 15.4 32.6 17.4 14.1 7.2 14.1 10.1 34.3 10.2 8.9 31.9 30.8 14.1 12.0 2.5 12.5 8.6 19.0 9.8 11.5 23.3 41.1 25.0 24.0 19.7 25.0 28.5 29.9 29.3 23.7 26.5 60.8 12.6 6.4 10.6 50.3 29.7 5.0 6.2 9.9 6.8 5.2 5.8 5.8 10.0 5.7 9.7 7.3 2.1 37.7 14.1 3.7 19.6 7.2 8.1 5.5 10.2 12.8 6.0 15.8 42.0 8.1 30.7 12.2 8.2 4.9 12.0 7.8 12.8 10.0 36.5 5.0 40.8 4.3 4.1 17.9 7.3 3.0 8.7 25.1 8.8 58.1 29.7 10.5 9.2 57.8 449.9 4.8 4.2 9.8 24.2 3.5 4.8 24.8 4.8 5.2 6.6 8.3 8.3 37.2 14.6 6.6 4.0 29.0 9.2 9.1 6.6 3.6 ATG4D "APG4-D, APG4D, AUTL4" ENSG00000130734 "Autophagy related 4D cysteine peptidase" Q86TL0 19 10543895-10553418 "Enzymes, Predicted intracellular proteins, Transporters" "Apoptosis, Autophagy, Protein transport, Transport, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 103.9;Proximal enterocytes: 109.3;Spermatocytes: 100.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "NB-4: 57.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA067683 Approved Supported Nucleoplasm,Mitochondria NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 24: NB-4 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Mitochondria" "HPA067683: AB_2685886" "unprognostic (2.85e-1)" "prognostic favorable (3.18e-5)" "unprognostic (2.73e-1)" "unprognostic (3.67e-1)" "unprognostic (2.18e-1)" "unprognostic (1.15e-2)" "unprognostic (3.52e-2)" "unprognostic (1.23e-1)" "unprognostic (4.28e-2)" "unprognostic (7.30e-2)" "prognostic favorable (9.95e-4)" "unprognostic (1.52e-1)" "prognostic favorable (2.39e-7)" "prognostic favorable (5.03e-4)" "unprognostic (3.78e-2)" "unprognostic (2.29e-1)" "unprognostic (3.18e-3)" 7.3 15.6 4.2 7.3 4.7 33.2 7.4 8.3 8.6 9.4 8.2 22.3 21.8 8.1 1.6 27.3 7.6 3.9 23.2 4.5 4.0 20.8 13.2 10.6 8.3 5.2 4.7 9.5 16.3 10.7 16.6 4.9 5.3 14.0 5.2 2.5 16.6 4.4 36.9 24.6 23.2 2.1 3.1 17.0 13.7 24.5 5.4 12.0 13.4 10.8 4.6 9.7 15.0 6.1 13.8 8.7 11.7 16.5 2.1 1.8 9.9 9.2 7.8 11.1 12.2 14.9 4.3 9.2 16.2 0.9 8.6 20.8 7.3 6.8 1.4 10.4 23.5 23.1 22.3 8.2 7.4 9.4 22.1 1.8 14.2 9.8 3.4 2.8 3.3 18.1 17.8 19.8 3.6 21.9 27.6 57.8 18.9 6.1 29.0 20.0 8.2 15.1 6.4 17.8 45.3 17.8 12.6 22.6 11.3 2.1 14.0 21.6 6.4 16.8 11.0 34.7 20.4 19.2 15.4 10.8 14.4 18.0 19.5 1.6 0.8 3.7 1.1 1.0 1.5 1.0 1.3 1.2 0.6 0.4 1.2 1.7 0.2 1.3 0.4 4.2 2.2 0.8 4.2 4.7 8.3 8.6 4.5 4.0 5.2 4.7 5.3 3.1 5.4 6.1 6.3 9.6 6.6 9.1 14.4 30.5 19.8 14.9 24.5 14.9 14.1 10.2 0.5 14.3 8.1 1.8 14.6 27.9 38.7 103.9 13.7 16.1 83.6 9.6 5.5 5.3 22.2 43.6 8.4 16.5 6.7 8.2 26.5 10.1 7.0 10.9 6.1 11.9 13.4 28.6 9.1 38.5 20.3 15.0 12.1 16.3 8.7 10.0 12.4 4.7 15.7 11.8 22.6 4.5 8.4 20.5 72.4 4.5 17.6 21.6 109.3 25.4 5.2 20.1 13.1 9.1 14.2 100.7 21.2 33.4 31.3 36.5 19.6 10.6 33.2 36.4 BAP1 "hucep-6, KIAA0272, UCHL2" ENSG00000163930 "BRCA1 associated protein 1" Q92560 3 52401008-52410008 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Chromatin regulator, Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 103.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004322, HPA028814, HPA028815, HPA055560" Approved Enhanced Nucleoplasm,Cytosol NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 34: Spermatids - Unknown function" Nucleoplasm Cytosol "CAB004322: AB_626723, HPA028814: AB_10602393, HPA028815: AB_2672785, HPA055560: AB_2682850" "unprognostic (1.52e-1)" "unprognostic (7.96e-2)" "unprognostic (1.96e-2)" "unprognostic (6.04e-2)" "unprognostic (1.74e-1)" "unprognostic (2.55e-2)" "unprognostic (9.41e-3)" "unprognostic (8.53e-3)" "unprognostic (1.33e-1)" "unprognostic (3.15e-1)" "unprognostic (4.64e-3)" "unprognostic (3.30e-3)" "prognostic favorable (3.29e-7)" "unprognostic (6.37e-2)" "unprognostic (1.91e-1)" "unprognostic (5.54e-2)" "unprognostic (2.92e-1)" 45.2 63.5 97.6 25.0 99.2 73.9 42.9 78.9 135.5 39.1 71.4 47.7 21.6 40.5 23.1 59.3 36.0 25.7 57.0 114.1 83.3 57.3 65.2 46.0 29.4 81.2 85.7 43.9 52.7 40.2 36.9 24.6 81.7 50.0 24.1 20.1 43.0 22.5 74.7 73.4 43.4 23.8 79.9 54.2 48.1 140.0 89.2 33.1 49.1 43.5 27.9 44.6 41.7 90.5 39.1 43.1 52.2 44.8 50.1 31.4 59.3 37.8 50.1 62.4 48.0 52.5 35.8 55.7 18.3 54.7 69.3 31.4 55.7 63.0 37.9 55.1 51.4 68.6 94.4 53.2 45.7 65.6 58.5 48.0 80.1 68.5 36.1 33.3 50.3 107.7 59.9 48.3 44.5 33.7 79.1 89.5 58.0 31.0 52.8 33.7 41.7 55.8 37.4 61.2 19.8 63.6 46.1 13.7 56.9 29.2 37.7 90.6 52.5 54.1 49.3 66.0 70.9 71.7 101.6 81.2 58.5 68.2 66.1 2.9 3.2 5.4 5.4 2.8 2.6 3.2 4.3 4.4 2.2 4.1 3.1 4.0 7.4 2.2 2.2 5.6 4.2 2.7 97.6 99.2 78.9 135.5 114.1 83.3 81.2 85.7 81.7 79.9 89.2 90.5 13.5 0.0 16.0 8.1 12.2 31.6 10.5 13.2 23.3 16.6 16.4 12.6 23.6 11.5 10.2 25.8 0.0 14.0 17.7 23.2 11.7 13.5 103.4 9.2 12.4 14.7 10.8 8.2 7.5 16.7 15.8 13.6 14.8 13.6 21.0 18.1 14.6 29.2 12.6 10.1 7.7 16.6 6.1 17.4 10.7 48.0 10.2 12.0 12.4 5.6 15.2 16.1 16.5 7.1 6.7 15.8 16.5 11.7 16.2 11.7 13.3 18.5 8.2 12.3 19.7 14.7 14.2 37.8 13.9 23.0 23.4 12.0 12.2 15.9 19.8 9.6 BLMH BH ENSG00000108578 "Bleomycin hydrolase" Q13867 17 30248203-30292056 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skin 1: 130.3" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039548, HPA064307" Enhanced Supported "Nucleoplasm,Nuclear bodies,Cytosol" No No 42000000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 24: Non-specific - Transcription regulation" "Nucleoplasm, Nuclear bodies, Cytosol" "HPA039548: AB_10805479, HPA064307: AB_2685241" "unprognostic (6.85e-2)" "unprognostic (2.79e-1)" "unprognostic (1.48e-1)" "unprognostic (2.46e-1)" "unprognostic (1.76e-1)" "unprognostic (2.54e-2)" "unprognostic (3.91e-3)" "unprognostic (2.07e-1)" "unprognostic (2.05e-3)" "unprognostic (6.69e-3)" "unprognostic (1.95e-3)" "unprognostic (2.14e-2)" "unprognostic (2.14e-2)" "unprognostic (1.22e-3)" "unprognostic (1.05e-1)" "unprognostic (1.34e-1)" "unprognostic (1.44e-1)" 20.6 13.5 13.4 18.2 15.0 18.1 20.4 15.9 17.6 19.1 14.5 18.8 12.4 21.2 21.1 28.3 14.7 18.4 15.6 13.5 15.2 22.0 14.0 16.0 26.0 15.6 14.1 13.9 26.8 21.7 9.7 27.4 15.4 14.4 15.4 14.7 15.6 14.4 28.8 130.3 18.3 22.4 14.7 20.6 16.2 15.9 14.2 36.3 16.5 19.0 26.9 17.9 21.5 16.2 40.3 62.9 61.5 41.6 40.6 43.8 27.8 36.5 24.0 59.1 50.8 93.2 11.9 119.5 63.3 31.1 26.1 27.1 135.5 52.8 50.1 31.5 101.4 73.5 54.6 80.0 58.3 136.1 43.2 50.5 3.5 46.5 26.5 47.1 87.2 98.2 157.9 47.6 24.6 31.0 168.1 98.6 57.2 0.0 29.2 143.0 154.5 78.9 46.8 35.6 135.1 48.4 32.6 63.2 42.2 106.6 42.9 68.5 54.5 35.0 69.2 16.0 66.0 55.8 124.1 159.3 26.7 0.2 47.6 0.0 8.8 1.5 15.3 6.2 25.3 6.5 18.2 20.2 10.1 7.3 16.4 17.8 1.2 16.3 3.3 10.1 20.0 9.9 13.4 15.0 15.9 17.6 13.5 15.2 15.6 14.1 15.4 14.7 14.2 16.2 21.0 3.2 12.6 13.4 8.8 15.9 16.7 10.6 19.4 20.2 10.3 6.6 17.8 12.8 4.0 11.0 12.5 49.6 15.6 7.6 7.9 17.4 8.4 7.4 28.2 24.0 18.0 22.5 19.0 14.2 38.0 18.3 11.2 7.0 43.8 30.5 25.7 6.9 25.0 13.5 20.9 8.4 6.1 18.9 7.1 6.6 16.1 13.0 10.6 18.7 12.2 9.9 22.6 29.1 22.6 7.2 9.6 24.8 20.0 13.0 11.5 20.0 5.5 15.7 6.6 12.9 19.7 14.9 29.1 24.0 12.6 27.5 20.9 34.8 11.5 7.6 CAPN1 "CANP, CANPL1, muCANP, muCL" ENSG00000014216 "Calpain 1" P07384 11 65180566-65212006 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "esophagus: 276.2" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RT4: 516.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005992 Enhanced Supported Cytosol NA NA 9100000 "Cluster 46: Basophils - DNA binding" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 15: RT4 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "HPA005992: AB_1845924" "unprognostic (2.07e-1)" "unprognostic (2.15e-1)" "unprognostic (2.69e-1)" "unprognostic (1.40e-1)" "unprognostic (4.06e-2)" "unprognostic (1.10e-1)" "unprognostic (1.91e-2)" "unprognostic (2.48e-2)" "unprognostic (7.23e-2)" "unprognostic (2.23e-2)" "prognostic unfavorable (4.30e-4)" "unprognostic (3.33e-1)" "prognostic favorable (7.06e-8)" "unprognostic (5.70e-3)" "unprognostic (1.51e-1)" "unprognostic (1.86e-1)" "unprognostic (2.98e-1)" 44.8 43.1 27.8 51.9 26.1 66.5 48.4 29.7 30.1 80.9 28.3 78.6 80.4 56.3 27.5 276.2 92.3 55.5 53.1 27.7 33.0 53.1 44.3 56.9 57.0 41.4 31.5 44.5 71.7 36.6 40.8 56.2 43.4 62.1 57.6 9.6 118.7 67.4 84.8 125.1 88.1 45.3 33.9 50.2 65.5 6.1 37.9 49.5 71.5 55.3 86.4 83.4 117.4 27.4 285.6 147.9 42.9 97.2 77.9 104.3 127.0 84.1 144.2 103.0 74.9 94.8 250.2 71.2 136.0 179.3 111.1 409.8 60.9 366.9 32.2 76.4 44.1 170.8 80.4 93.7 76.2 40.6 228.0 107.3 196.8 85.9 43.2 92.6 178.5 50.6 103.1 55.9 87.4 181.8 83.1 130.6 120.5 145.2 133.8 80.7 43.0 43.2 138.1 516.5 76.2 55.7 87.4 331.4 80.3 45.8 142.8 77.9 147.1 73.1 50.5 159.0 38.5 33.8 26.9 86.6 127.5 48.8 82.3 87.6 57.5 77.9 39.4 51.2 31.0 30.8 30.7 35.8 48.4 31.7 17.6 24.9 33.1 34.8 30.4 38.1 35.9 74.8 27.8 26.1 29.7 30.1 27.7 33.0 41.4 31.5 43.4 33.9 37.9 27.4 27.3 25.6 27.9 21.5 39.6 59.9 127.3 120.5 56.9 10.7 44.7 36.6 22.0 74.4 81.0 77.3 20.9 238.5 61.4 184.2 39.2 180.5 0.5 41.9 26.3 31.3 44.3 58.3 15.9 115.8 111.7 39.6 57.6 58.2 46.9 48.6 37.9 36.7 88.7 21.9 15.2 76.9 59.0 51.2 34.0 2.0 43.5 67.1 48.0 14.0 112.7 38.5 61.8 6.6 1.9 179.4 124.1 50.8 17.7 78.6 155.6 34.6 71.1 16.2 39.5 25.3 36.7 0.5 2.8 102.0 68.9 196.6 40.2 35.4 125.3 156.6 CAPN10 ENSG00000142330 "Calpain 10" Q9HC96 2 240586734-240617705 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Diabetes mellitus" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Horizontal cells: 48.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004170, HPA056098" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 35: Non-specific - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 62: Horizontal cells - Visual perception" Nucleoplasm Cytosol "HPA004170: AB_1078381, HPA056098: AB_2683037" "unprognostic (1.05e-1)" "unprognostic (1.13e-2)" "unprognostic (9.29e-3)" "unprognostic (6.09e-2)" "unprognostic (5.44e-3)" "prognostic favorable (8.47e-5)" "prognostic unfavorable (4.78e-6)" "unprognostic (7.48e-3)" "unprognostic (7.94e-2)" "unprognostic (1.31e-2)" "prognostic favorable (7.94e-5)" "unprognostic (1.46e-1)" "unprognostic (1.11e-2)" "unprognostic (1.19e-1)" "unprognostic (6.88e-2)" "unprognostic (5.76e-2)" "unprognostic (5.58e-3)" 10.0 18.6 16.8 6.8 16.2 7.9 9.6 21.0 25.0 11.8 16.5 12.7 13.1 10.7 3.7 14.5 13.7 6.1 24.6 17.9 14.0 23.8 14.7 12.2 10.6 15.6 15.8 13.3 12.6 5.3 18.1 4.5 15.4 14.9 7.1 10.6 10.2 5.3 5.8 12.1 14.0 2.8 12.6 29.8 15.8 17.0 16.7 6.4 13.2 2.8 5.4 11.1 10.0 16.8 8.0 11.2 11.2 9.5 4.5 3.6 19.7 9.9 4.1 6.5 5.9 8.7 18.7 5.9 3.5 3.6 8.9 12.7 3.0 6.6 3.3 23.0 19.8 10.9 20.4 16.0 7.1 7.1 15.3 2.6 4.8 6.7 2.7 6.7 5.2 16.8 12.5 7.3 2.8 7.1 16.2 27.5 17.4 9.5 8.1 15.5 8.1 13.1 9.9 9.8 28.1 22.0 6.3 9.3 13.8 3.5 4.8 9.3 8.6 11.0 9.7 9.5 11.8 16.3 4.2 10.7 10.4 12.8 11.0 1.5 0.9 1.8 1.0 0.6 0.3 1.0 0.6 1.1 0.4 1.1 0.7 0.9 4.1 3.0 0.6 1.2 1.3 0.4 16.8 16.2 21.0 25.0 17.9 14.0 15.6 15.8 15.4 12.6 16.7 16.8 8.9 3.2 6.0 19.6 7.5 4.6 7.2 3.8 6.2 14.9 6.2 5.3 9.5 12.8 4.8 9.2 14.6 5.4 14.2 7.2 7.9 13.0 1.9 14.7 5.7 7.0 11.3 1.7 9.5 9.1 5.2 5.3 4.6 13.8 22.9 11.3 7.5 3.0 6.7 48.8 9.0 6.3 8.2 5.3 1.7 2.6 9.0 7.8 1.8 7.5 7.7 13.4 8.2 7.5 7.2 13.8 4.6 9.4 7.4 10.1 9.9 6.2 9.4 18.6 0.0 5.6 7.6 12.6 7.7 3.7 5.3 5.5 11.3 9.0 6.4 6.9 CAPN11 ENSG00000137225 "Calpain 11" Q9UMQ6 6 44158811-44184401 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 13 "testis: 30.3" "Cell type enhanced" "Detected in some" "Adipocytes: 14.0;Breast myoepithelial cells: 11.8;Early spermatids: 24.7;Late spermatids: 9.8;Spermatocytes: 50.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "NTERA-2: 2.2;TIME: 5.8" "Not detected" "Not detected" "Low region specificity" "Detected in many" "CAB018070, HPA030955" Enhanced NA NA "Cluster 83: Testis - Spermatogenesis" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 66: Spermatocytes - Spermatogenesis" "CAB018070: AB_2069481, HPA030955: AB_2673672" "unprognostic (2.20e-2)" "unprognostic (1.87e-1)" "unprognostic (1.64e-2)" "unprognostic (2.75e-1)" "unprognostic (6.22e-2)" "unprognostic (3.34e-2)" "unprognostic (3.99e-2)" "unprognostic (4.57e-2)" "unprognostic (1.29e-1)" "unprognostic (8.96e-2)" "unprognostic (1.01e-1)" "unprognostic (2.13e-1)" "unprognostic (3.62e-6)" "unprognostic (2.38e-2)" "unprognostic (3.51e-1)" "unprognostic (2.27e-2)" "unprognostic (8.89e-2)" 1.6 0.4 0.2 0.3 0.2 0.5 2.3 0.4 0.5 0.8 0.1 0.2 0.0 0.3 0.5 0.2 0.3 0.3 0.3 0.3 0.3 0.2 0.1 0.2 0.4 0.2 0.1 0.0 0.1 0.1 0.0 0.5 0.2 0.3 0.1 0.1 0.4 0.0 0.1 0.8 0.4 0.3 0.1 0.1 0.2 30.3 0.3 2.2 0.3 0.2 0.3 0.4 0.5 0.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.8 0.0 0.2 0.2 0.0 0.0 0.0 0.1 2.2 0.0 0.0 0.3 0.1 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.1 5.8 0.2 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.2 0.2 0.4 0.5 0.3 0.3 0.2 0.1 0.2 0.1 0.3 0.5 14.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.5 11.8 0.5 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 24.7 0.0 0.0 3.9 0.0 2.7 0.5 0.0 0.0 0.7 0.0 0.2 0.0 0.1 1.1 0.0 1.3 0.0 0.3 0.1 0.0 0.3 0.3 9.8 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.7 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.2 50.0 0.9 0.1 0.0 0.0 0.1 0.1 0.1 0.1 CAPN12 ENSG00000182472 "Calpain 12" Q6ZSI9 19 38730187-38769904 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "gallbladder: 22.8;liver: 24.8" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 41.4;Cholangiocytes: 41.5;NK-cells: 39.1" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Group enriched" "Detected in many" 9 "basophil: 59.3;NK-cell: 25.5" "Group enriched" "Detected in many" 9 "granulocytes: 59.3;NK-cells: 25.5" "Cell line enriched" "Detected in some" 14 "HMC-1: 35.1" "Not detected" "Not detected" "Region enhanced" "Detected in single" "hippocampal formation: 3.0" HPA053322 Approved "Nucleoplasm,Focal adhesion sites" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 3: HMC-1 - Innate immune response" "Cluster 63: NK-cells & T-cells - Immune response" "Focal adhesion sites" Nucleoplasm "HPA053322: AB_2682111" "unprognostic (1.81e-1)" "unprognostic (4.48e-2)" "unprognostic (1.04e-2)" "unprognostic (1.08e-1)" "unprognostic (1.95e-2)" "unprognostic (2.81e-2)" "unprognostic (1.02e-1)" "unprognostic (6.01e-3)" "unprognostic (7.20e-2)" "unprognostic (2.45e-2)" "unprognostic (1.29e-1)" "unprognostic (4.01e-2)" "prognostic unfavorable (5.90e-6)" "unprognostic (7.04e-2)" "unprognostic (4.01e-2)" "unprognostic (3.00e-1)" "unprognostic (4.59e-2)" 0.5 0.2 0.4 1.3 0.4 0.5 0.6 0.3 0.7 5.3 0.3 1.1 2.6 1.1 0.7 1.0 2.9 22.8 1.1 0.3 0.7 3.5 24.8 2.5 2.2 0.5 0.4 0.3 1.9 0.5 0.3 0.2 0.7 0.4 1.0 0.0 5.3 1.2 0.4 4.0 1.0 0.8 0.3 1.9 2.0 0.5 0.7 1.3 0.3 0.0 2.8 0.5 0.9 0.4 0.2 1.4 0.0 0.0 0.2 0.1 2.0 0.0 0.0 0.0 0.1 2.4 0.1 0.6 0.0 0.0 0.3 1.0 0.0 0.6 0.0 0.1 0.0 0.2 0.7 0.7 0.0 0.0 35.1 0.6 2.0 0.2 0.0 0.0 0.0 0.0 0.4 0.4 0.2 0.2 0.0 0.0 0.4 0.8 0.0 0.0 0.0 0.1 1.4 0.0 0.1 0.0 0.1 0.3 0.0 0.3 0.1 1.1 0.0 0.0 0.0 0.0 0.4 0.7 0.6 0.0 0.1 0.0 0.5 59.3 0.1 3.6 4.4 0.0 4.4 2.6 1.3 2.4 0.1 3.8 0.0 1.1 0.7 25.5 0.0 0.0 1.0 1.2 0.4 0.4 0.3 0.7 0.3 0.7 0.5 0.4 0.7 0.3 0.7 0.4 2.5 12.8 41.4 0.7 14.8 9.4 9.2 16.5 4.0 1.6 3.3 4.6 0.9 41.5 8.5 5.5 0.0 1.7 17.7 4.3 0.0 11.6 0.8 7.8 2.8 2.6 3.6 1.3 0.5 7.2 9.4 1.1 8.6 21.2 5.1 0.9 2.5 16.1 1.0 0.0 0.2 21.4 10.2 1.3 3.3 0.6 0.6 1.4 3.6 1.0 1.0 1.4 39.1 0.0 0.3 5.4 6.0 0.4 9.8 5.4 9.7 21.7 10.0 0.6 0.0 2.3 3.0 0.3 2.4 3.4 9.5 2.9 19.1 2.2 15.7 4.8 CAPN13 FLJ23523 ENSG00000162949 "Calpain 13" Q6MZZ7 2 30722771-30820542 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 29.2;stomach 1: 28.5" "Cell type enhanced" "Detected in many" "Club cells: 76.6;Gastric mucus-secreting cells: 50.0;Proximal enterocytes: 35.2;Undifferentiated cells: 18.1;Urothelial cells: 19.4" "Cancer enhanced" "Detected in many" "endometrial cancer: 11.3" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "RT4: 9.3;SK-BR-3: 21.9" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA029496, HPA029497, HPA030034" Uncertain Approved Nucleoplasm NA NA "Cluster 9: Intestine - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Nucleoplasm "HPA029496: AB_2673072, HPA029497: AB_2673073, HPA030034: AB_2673281" "unprognostic (7.42e-2)" "unprognostic (1.19e-1)" "unprognostic (7.01e-3)" "unprognostic (1.96e-1)" "unprognostic (8.56e-2)" "unprognostic (1.51e-1)" "unprognostic (1.68e-1)" "unprognostic (1.32e-3)" "unprognostic (2.17e-1)" "unprognostic (2.66e-2)" "unprognostic (1.11e-1)" "unprognostic (2.49e-1)" "unprognostic (1.96e-2)" "unprognostic (3.64e-1)" "unprognostic (3.32e-2)" "unprognostic (5.03e-2)" "unprognostic (4.28e-3)" 0.0 0.0 0.8 0.0 1.4 0.0 7.2 0.9 1.3 9.7 1.0 11.4 20.8 0.2 0.3 0.9 1.1 2.8 0.0 0.7 0.8 2.5 0.2 7.2 0.0 1.1 1.3 0.0 3.6 0.4 0.2 0.0 1.0 3.8 24.6 0.0 1.2 0.1 0.0 0.2 29.2 0.2 1.0 0.1 28.5 0.1 1.1 0.0 0.0 0.0 0.6 4.1 0.5 2.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.6 9.3 0.1 0.4 0.0 21.9 0.0 0.7 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 1.4 0.9 1.3 0.7 0.8 1.1 1.3 1.0 1.0 1.1 2.3 0.0 6.4 3.1 0.3 0.0 0.0 10.2 3.5 4.0 0.0 4.2 1.8 1.3 0.0 76.6 1.8 0.0 0.0 0.0 16.9 0.0 1.3 0.8 2.0 0.0 0.1 15.0 0.0 0.3 5.3 0.0 0.6 50.0 0.7 1.3 0.0 0.0 0.0 0.0 0.0 1.5 12.0 6.1 0.0 0.0 0.4 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 8.4 1.9 6.2 0.0 0.0 2.7 35.2 0.2 12.4 0.0 0.0 0.0 6.1 0.0 0.1 1.4 0.0 0.0 0.1 0.0 18.1 19.4 CAPN14 ENSG00000214711 "Calpain 14" A8MX76 2 31173056-31233858 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 17 "esophagus: 144.1" "Cell type enhanced" "Detected in some" "Excitatory neurons: 3.2;Inhibitory neurons: 4.2;Squamous epithelial cells: 8.2;Urothelial cells: 15.5" "Cancer enhanced" "Detected in some" "cervical cancer: 2.9;head and neck cancer: 2.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "RT4: 1.1;U-266/70: 3.4" "Not detected" "Not detected" NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 29: U-266 - Adaptive immune response" "Cluster 22: Epithelial cell types - Mixed function" "unprognostic (5.81e-3)" "unprognostic (1.20e-1)" "unprognostic (4.57e-2)" "unprognostic (1.88e-2)" "unprognostic (3.85e-2)" "unprognostic (3.30e-1)" "unprognostic (3.61e-2)" "unprognostic (4.67e-2)" "unprognostic (1.71e-1)" "unprognostic (3.14e-1)" "unprognostic (3.77e-1)" "unprognostic (1.60e-1)" "unprognostic (3.71e-4)" "unprognostic (8.42e-2)" "unprognostic (6.84e-2)" "unprognostic (1.91e-1)" "unprognostic (4.47e-4)" 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 144.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.9 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 8.2 0.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.1 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 1.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.9 0.0 0.5 0.1 0.6 0.8 0.1 0.0 1.7 0.0 0.7 0.0 0.0 0.1 0.1 0.4 0.0 0.0 0.6 0.8 0.1 0.2 0.0 0.0 3.2 0.0 0.1 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.1 1.7 4.2 0.0 0.0 0.3 0.0 0.8 0.0 0.0 0.0 0.0 0.1 0.0 1.0 0.5 0.5 0.0 2.2 0.0 0.0 0.7 0.0 0.0 0.0 1.4 0.0 0.0 0.1 0.0 0.2 8.2 0.0 1.4 0.1 0.0 0.1 15.5 CAPN15 SOLH ENSG00000103326 "Calpain 15" O75808 16 527712-554636 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 54.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Group enriched" "Detected in many" 4 "basophil: 4.7;neutrophil: 16.2" "Lineage enriched" "Detected in many" 7 "granulocytes: 16.2" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011960 Uncertain Approved Nucleoplasm NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 18: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "HPA011960: AB_10610556" "unprognostic (4.11e-2)" "unprognostic (1.63e-1)" "unprognostic (1.14e-1)" "unprognostic (2.66e-1)" "unprognostic (7.18e-2)" "unprognostic (1.12e-2)" "unprognostic (1.54e-3)" "unprognostic (8.31e-3)" "unprognostic (1.32e-1)" "unprognostic (1.24e-1)" "unprognostic (1.86e-1)" "unprognostic (4.02e-2)" "unprognostic (2.53e-3)" "unprognostic (2.54e-3)" "unprognostic (5.91e-2)" "unprognostic (1.83e-1)" "unprognostic (9.23e-3)" 13.0 12.0 3.6 7.2 2.5 8.1 10.8 11.6 6.2 12.2 0.2 20.2 16.3 13.4 0.4 18.5 13.2 1.6 11.2 3.2 0.2 18.4 17.2 15.3 5.1 4.1 1.0 13.2 24.8 2.2 15.2 2.6 1.4 12.3 2.3 1.1 12.6 2.8 14.9 22.3 22.7 1.2 0.2 21.2 16.5 18.7 2.1 2.8 11.7 0.9 2.5 12.5 12.8 0.8 16.8 21.5 3.0 9.3 1.7 3.4 46.2 17.5 4.6 4.9 3.3 28.2 12.1 24.0 16.3 3.2 5.0 21.9 2.0 6.9 1.8 25.2 37.1 20.2 25.7 17.6 7.3 23.8 27.3 3.9 4.0 4.9 2.2 2.9 5.3 14.7 37.6 7.1 1.6 25.9 27.1 26.0 26.7 8.6 20.2 46.5 8.7 24.2 3.3 11.0 19.6 17.8 11.7 16.2 10.2 1.8 13.3 24.7 26.2 15.3 21.4 15.7 22.0 18.2 11.0 21.3 6.7 13.8 9.7 4.7 1.3 0.8 0.3 0.8 0.1 0.4 0.1 0.4 0.3 2.3 0.1 0.2 16.2 1.1 1.3 0.5 0.2 0.3 3.6 2.5 11.6 6.2 3.2 0.2 4.1 1.0 1.4 0.2 2.1 0.8 7.6 3.2 8.4 10.1 5.9 8.9 5.7 6.2 3.4 12.1 7.6 6.6 3.1 8.6 5.6 7.3 16.7 3.7 22.3 54.3 1.9 6.2 16.5 6.1 8.9 8.7 4.2 1.7 10.6 15.7 4.4 6.9 20.4 13.3 7.0 10.8 8.9 16.5 6.8 20.2 11.3 26.9 8.2 12.0 6.8 6.2 7.5 8.2 1.8 7.5 6.5 9.1 23.7 10.6 7.8 14.3 37.1 4.5 5.8 13.4 33.1 5.7 4.6 11.2 0.0 10.2 5.2 5.3 7.4 5.8 8.0 2.5 9.2 9.6 25.9 11.6 CAPN2 "CANPL2, CANPml, mCANP" ENSG00000162909 "Calpain 2" P17655 1 223701593-223776018 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "TIME: 858.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024470 Approved Approved Supported Cytosol NA NA 2800000 "Cluster 39: Non-specific - mRNA processing" "Cluster 46: Fibroblasts - ECM organization" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 16: Pancreatic endocrine cells - Mixed function" Cytosol "HPA024470: AB_1845925" "unprognostic (2.77e-2)" "unprognostic (1.27e-3)" "unprognostic (2.03e-1)" "unprognostic (3.39e-2)" "unprognostic (2.12e-1)" "unprognostic (3.32e-2)" "unprognostic (1.59e-1)" "unprognostic (1.10e-1)" "unprognostic (2.85e-1)" "unprognostic (1.96e-1)" "prognostic unfavorable (2.50e-4)" "unprognostic (1.21e-1)" "prognostic favorable (2.19e-4)" "unprognostic (1.61e-1)" "unprognostic (2.63e-1)" "unprognostic (2.62e-1)" "prognostic unfavorable (6.21e-4)" 118.8 93.9 40.2 64.9 50.0 40.9 92.4 45.3 39.6 110.4 29.4 140.1 46.2 67.7 58.0 134.3 120.5 119.7 71.8 36.9 42.7 115.2 31.2 182.5 35.5 51.9 46.1 83.2 55.1 136.3 28.0 68.3 46.6 47.5 131.4 19.2 151.2 91.2 82.2 41.6 58.5 87.3 43.4 42.5 130.4 26.3 49.1 27.0 80.9 81.6 54.3 85.6 89.3 49.3 419.9 263.7 79.2 54.9 257.6 356.6 79.4 383.9 541.3 267.2 151.1 209.2 323.6 0.4 125.0 417.1 209.1 255.1 86.3 593.1 243.4 109.8 95.2 7.8 124.9 25.6 232.3 21.5 13.9 193.3 187.3 416.6 217.8 472.3 537.1 0.1 123.2 106.8 789.3 8.6 1.0 19.4 45.5 49.7 346.3 35.4 262.4 7.3 454.9 24.3 17.7 94.7 198.1 524.2 122.8 189.7 80.9 98.7 858.1 252.7 212.0 220.6 498.4 32.5 66.8 1.4 625.3 46.2 284.7 7.9 118.6 7.2 106.8 77.9 89.8 34.4 72.6 103.2 163.9 16.6 22.9 62.2 6.1 24.5 73.7 7.4 81.7 136.6 40.2 50.0 45.3 39.6 36.9 42.7 51.9 46.1 46.6 43.4 49.1 49.3 240.0 394.2 134.9 82.9 42.3 47.3 136.6 197.5 38.7 12.0 35.7 32.8 38.4 115.8 264.4 53.3 33.3 24.4 72.4 356.0 181.9 271.4 94.5 70.0 52.7 125.3 24.6 6.9 13.3 195.9 92.0 105.0 103.5 93.3 27.8 47.8 35.7 9.7 38.9 13.5 23.1 104.4 242.1 50.0 239.3 232.8 77.3 86.4 112.1 22.5 66.0 22.6 78.2 48.7 21.6 373.0 191.5 68.8 83.3 237.7 104.1 23.6 288.8 18.0 39.5 85.0 107.9 3.4 3.3 67.5 27.6 8.2 83.5 63.5 98.2 268.2 CAPN3 "CANP3, LGMD2, LGMD2A, nCL-1, p94" ENSG00000092529 "Calpain 3" P20807 15 42359498-42412949 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Disease variant, Limb-girdle muscular dystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 279.2;skeletal muscle: 905.9;tongue: 377.4" "Group enriched" "Detected in many" 5 "Early spermatids: 512.5;Late spermatids: 183.6;Melanocytes: 482.0;Oligodendrocytes: 220.2" "Cancer enriched" "Detected in some" 10 "melanoma: 9.1" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enriched" "Detected in many" 27 "SK-MEL-30: 238.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040052 Enhanced NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 80: Striated muscle - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 23: Spermatids - Flagellum & Golgi organization" "HPA040052: AB_2676821" "unprognostic (1.06e-2)" "unprognostic (1.31e-1)" "unprognostic (4.00e-2)" "unprognostic (8.71e-2)" "unprognostic (1.53e-1)" "unprognostic (1.72e-2)" "unprognostic (2.11e-4)" "unprognostic (3.12e-3)" "unprognostic (2.82e-1)" "unprognostic (2.47e-1)" "unprognostic (2.37e-3)" "unprognostic (3.26e-2)" "unprognostic (3.91e-4)" "unprognostic (5.56e-3)" "unprognostic (2.43e-1)" "unprognostic (8.93e-3)" "unprognostic (1.38e-1)" 13.5 8.8 136.1 4.0 206.6 47.6 14.1 194.2 243.3 18.8 113.0 13.3 3.1 11.2 163.7 14.5 13.7 4.5 16.1 142.9 159.9 93.6 36.9 21.5 7.0 212.0 194.9 15.7 8.7 2.4 11.3 3.0 212.1 16.0 5.3 7.5 18.6 5.2 905.9 54.9 14.0 4.7 155.2 19.1 8.9 30.8 187.8 3.4 10.7 377.4 5.1 11.7 15.5 279.2 0.5 0.3 0.6 1.1 8.8 6.1 0.6 2.6 1.9 0.5 0.8 1.2 0.5 0.2 0.9 1.6 0.4 3.7 0.4 3.5 0.3 0.9 0.8 0.8 0.8 4.1 0.6 1.0 1.5 4.7 3.7 0.8 0.7 1.5 0.1 0.7 0.2 1.8 0.7 0.1 0.2 1.2 0.4 0.2 0.9 1.1 0.4 1.9 1.9 1.3 0.4 0.1 0.2 0.5 238.0 1.0 0.0 5.4 0.9 0.3 0.4 2.6 0.7 1.5 2.1 0.2 0.4 2.4 1.8 0.5 1.0 0.1 0.7 0.2 0.8 0.3 0.1 0.3 0.5 0.5 0.1 0.9 0.9 0.6 0.1 0.5 0.4 0.6 136.1 206.6 194.2 243.3 142.9 159.9 212.0 194.9 212.1 155.2 187.8 279.2 0.5 12.8 34.5 16.0 2.9 20.1 0.8 2.2 3.4 2.2 0.4 0.3 0.4 1.5 4.4 1.8 2.1 0.7 1.4 2.0 1.9 0.1 512.5 0.5 0.6 2.2 0.0 0.0 4.0 0.0 0.6 1.6 3.6 0.7 1.3 0.4 2.2 8.7 32.7 0.0 5.2 1.8 2.0 4.4 11.6 183.6 5.3 2.9 482.0 13.1 2.5 3.7 2.1 4.5 220.2 0.0 5.4 3.4 0.6 0.9 2.4 59.5 2.6 3.9 0.0 13.8 1.6 15.9 4.7 1.6 8.5 3.3 1.8 1.2 2.3 0.8 CAPN5 "ADNIV, HTRA3, nCL-3, VRNI" ENSG00000149260 "Calpain 5" O15484 11 77066961-77126155 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 60.7" "Cell type enhanced" "Detected in many" "Distal enterocytes: 170.3;Gastric mucus-secreting cells: 80.0;Intestinal goblet cells: 89.8;Paneth cells: 72.6;Proximal enterocytes: 75.6;Undifferentiated cells: 69.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "gdT-cell: 1.3" "Lineage enriched" "Detected in single" 4 "T-cells: 1.3" "Cell line enhanced" "Detected in many" "OE19: 106.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033237, HPA072319" Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm Cytosol "CAB033237: AB_2069673, HPA072319: AB_2686512" "unprognostic (6.81e-3)" "unprognostic (1.31e-1)" "unprognostic (3.36e-2)" "prognostic unfavorable (2.16e-6)" "unprognostic (3.47e-3)" "unprognostic (1.34e-1)" "unprognostic (1.13e-1)" "unprognostic (5.30e-2)" "unprognostic (2.52e-1)" "unprognostic (2.21e-2)" "unprognostic (5.35e-3)" "unprognostic (4.64e-1)" "unprognostic (3.17e-3)" "unprognostic (8.58e-3)" "unprognostic (3.25e-1)" "unprognostic (2.31e-2)" "unprognostic (2.30e-3)" 6.7 12.2 8.5 10.9 7.9 2.7 4.9 6.4 8.6 13.5 3.5 60.5 60.7 10.0 5.7 31.6 10.8 36.3 7.2 8.5 8.7 15.1 52.1 4.8 1.9 11.7 8.2 13.2 5.6 1.0 5.1 2.8 12.5 16.0 49.9 3.8 7.7 8.9 1.6 3.1 52.4 11.3 9.9 3.5 47.9 21.5 7.9 2.8 4.7 1.7 2.7 15.4 10.5 8.1 0.8 12.5 8.6 7.8 32.0 30.4 0.7 11.8 22.9 13.4 10.0 6.9 3.6 0.4 7.7 24.5 14.4 0.5 3.8 1.0 6.4 0.5 0.8 2.1 0.5 0.9 7.9 0.2 0.4 16.1 1.4 22.6 5.2 18.8 14.4 5.1 0.2 0.0 26.9 19.9 1.8 0.3 6.6 106.6 9.3 2.0 27.0 0.4 4.6 16.4 0.5 13.5 1.0 2.7 5.9 5.7 1.7 0.1 23.9 25.4 12.3 34.8 1.3 0.8 1.7 0.1 13.1 0.3 5.7 0.0 0.2 0.0 1.3 0.3 0.1 0.0 0.1 0.5 0.2 0.0 0.6 0.8 0.0 0.0 0.0 0.1 0.0 0.7 8.5 7.9 6.4 8.6 8.5 8.7 11.7 8.2 12.5 9.9 7.9 8.1 1.6 0.0 0.5 4.2 1.0 1.7 0.3 2.2 0.0 3.1 0.5 1.8 1.7 24.3 10.3 23.9 0.0 0.1 3.4 170.3 1.9 10.3 1.1 1.9 5.9 2.4 22.3 5.7 4.6 32.7 0.4 7.6 80.0 3.5 0.0 10.2 2.9 40.4 0.9 1.7 6.7 89.8 10.2 1.6 1.8 1.3 12.5 1.2 7.2 1.0 0.3 5.8 5.2 11.6 0.7 22.4 72.6 4.5 0.9 2.0 75.6 9.9 11.1 2.1 0.0 8.3 4.1 0.5 2.3 2.5 0.9 0.0 1.5 5.3 69.2 2.4 CAPN6 "CalpM, CANPX, CAPNX" ENSG00000077274 "Calpain 6" Q9Y6Q1 X 111245099-111270483 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "epididymis: 212.7;placenta: 83.1;seminal vesicle: 72.4" "Group enriched" "Detected in some" 4 "Extravillous trophoblasts: 198.5;Syncytiotrophoblasts: 140.5" "Cancer enhanced" "Detected in many" "endometrial cancer: 25.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "HDLM-2: 10.8;NTERA-2: 16.3;SuSa: 14.3" "Low region specificity" "Detected in many" "Region enhanced" "Detected in many" "spinal cord: 9.6" HPA040259 Approved "Nucleoplasm,Centriolar satellite,Cytosol" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 30: Epididymis - Antimicrobial activity" "Cluster 5: NTERA-2 - Transcription" "Cluster 38: Extravillous trophoblasts - Unknown function" "Centriolar satellite" "Nucleoplasm, Cytosol" "HPA040259: " "unprognostic (1.27e-3)" "unprognostic (2.04e-1)" "unprognostic (2.69e-2)" "unprognostic (5.77e-3)" "unprognostic (2.07e-1)" "unprognostic (9.93e-2)" "unprognostic (8.39e-3)" "unprognostic (1.06e-1)" "unprognostic (2.08e-1)" "unprognostic (9.45e-3)" "unprognostic (5.12e-1)" "unprognostic (6.25e-2)" "unprognostic (7.67e-2)" "unprognostic (6.50e-2)" "unprognostic (5.02e-3)" "unprognostic (2.66e-1)" "unprognostic (6.30e-2)" 2.1 0.0 0.0 7.2 0.0 0.0 12.7 0.0 0.0 11.9 0.0 5.6 1.8 22.5 212.7 2.3 3.2 8.4 0.3 0.0 0.0 11.5 0.3 0.5 2.8 0.0 0.0 2.6 7.5 0.1 0.2 83.1 0.0 10.6 8.6 0.0 14.1 72.4 3.0 1.0 1.7 8.2 0.0 1.7 12.9 2.0 0.0 1.8 1.5 9.0 4.7 3.8 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 10.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 16.3 0.0 0.0 0.0 0.0 0.1 1.4 0.0 0.1 0.3 0.4 0.3 0.0 14.3 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 1.1 0.0 1.2 0.0 0.6 2.0 0.3 7.2 0.0 7.3 0.0 39.9 0.1 0.1 3.9 8.3 0.0 18.0 4.3 0.4 0.0 0.0 0.0 0.7 198.5 12.9 6.6 40.1 0.0 0.0 0.0 0.0 7.6 0.0 0.1 1.2 0.0 0.0 0.3 0.5 0.9 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 22.2 0.1 0.4 0.0 0.2 0.0 0.0 0.0 1.0 0.5 0.1 0.1 0.9 0.0 140.5 0.3 0.9 0.5 0.3 CAPN7 PalBH ENSG00000131375 "Calpain 7" Q9Y6W3 3 15206152-15252916 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004745, HPA046617" Uncertain Approved Centrosome,Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 28: BEWO - Transcription regulation" "Cluster 46: Photoreceptor cells - Phototransduction" Cytosol Centrosome "HPA004745: , HPA046617: AB_2679721" "unprognostic (2.70e-2)" "unprognostic (2.79e-1)" "prognostic favorable (4.85e-5)" "unprognostic (1.85e-1)" "unprognostic (1.69e-2)" "unprognostic (1.41e-2)" "unprognostic (2.22e-3)" "unprognostic (2.72e-1)" "unprognostic (1.42e-1)" "unprognostic (2.76e-1)" "unprognostic (1.39e-1)" "unprognostic (5.29e-2)" "unprognostic (1.12e-3)" "unprognostic (3.24e-2)" "unprognostic (7.84e-2)" "unprognostic (5.66e-2)" "unprognostic (1.05e-2)" 13.9 11.9 4.6 11.6 5.9 13.2 16.6 12.5 5.4 16.9 9.3 12.1 12.9 16.1 14.9 11.4 14.4 11.1 11.6 4.1 8.1 15.2 19.1 12.1 14.3 5.9 5.7 19.8 15.3 20.1 9.2 12.9 5.5 14.1 12.2 28.5 13.9 12.7 25.3 11.6 13.6 13.8 6.0 11.4 14.0 12.1 6.8 16.9 23.5 16.5 15.7 10.2 9.8 9.7 14.3 18.5 15.1 9.5 26.0 20.1 51.4 18.1 20.8 22.1 16.7 13.3 10.0 24.6 12.3 20.7 13.6 9.7 22.5 23.3 19.0 23.7 17.5 30.8 24.8 17.7 19.3 25.1 15.0 13.9 33.2 28.7 14.1 20.9 15.9 23.3 30.3 25.1 21.6 20.8 17.9 10.5 14.5 20.7 17.7 10.2 25.1 17.1 16.4 25.8 12.2 15.8 29.5 15.7 20.8 19.2 27.9 25.8 14.4 19.8 14.9 25.9 21.4 17.2 37.1 12.4 18.1 18.0 17.5 4.6 3.0 5.1 3.3 2.5 5.3 3.5 3.6 2.8 2.9 3.1 4.9 4.6 1.8 3.6 4.4 2.4 3.0 3.0 4.6 5.9 12.5 5.4 4.1 8.1 5.9 5.7 5.5 6.0 6.8 9.7 15.8 12.8 23.6 44.1 35.0 21.4 13.5 10.6 47.3 42.7 20.3 16.0 33.2 8.6 20.6 1.8 56.3 21.2 21.7 11.2 9.8 12.6 15.5 32.2 31.5 19.0 20.9 14.9 60.2 16.9 12.6 27.6 30.1 29.9 15.8 28.9 14.6 20.8 12.2 55.5 65.8 11.3 4.1 11.9 23.0 14.8 24.8 20.9 21.4 49.6 18.4 31.2 10.3 73.9 86.0 13.0 6.9 26.4 52.8 20.0 16.7 15.2 34.9 98.1 39.5 31.5 24.8 26.8 17.8 29.7 23.2 26.1 34.2 21.1 11.8 14.3 CAPN8 nCL-2 ENSG00000203697 "Calpain 8" A6NHC0 1 223538007-223665723 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 9 "stomach 1: 291.1" "Cell type enriched" "Detected in many" 6 "Gastric mucus-secreting cells: 910.8" "Cancer enhanced" "Detected in many" "pancreatic cancer: 28.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 12 "OE19: 125.9;RT4: 76.8" "Not detected" "Not detected" "Not detected" "Not detected" HPA073939 Approved "Nucleoplasm,Nuclear membrane,Vesicles" No NA "Cluster 4: Stomach - Digestion" "Cluster 21: OE19 - Mitochondria" "Cluster 16: Pancreatic endocrine cells - Mixed function" "Nucleoplasm, Nuclear membrane, Vesicles" "HPA073939: AB_2686646" "unprognostic (4.87e-3)" "unprognostic (2.58e-1)" "unprognostic (1.89e-1)" "unprognostic (2.06e-2)" "unprognostic (1.32e-2)" "unprognostic (1.49e-1)" "unprognostic (7.97e-3)" "unprognostic (1.19e-1)" "unprognostic (1.26e-1)" "unprognostic (8.08e-2)" "unprognostic (2.72e-3)" "unprognostic (3.55e-1)" "unprognostic (4.12e-6)" "unprognostic (6.95e-2)" "unprognostic (5.59e-2)" "unprognostic (3.83e-2)" "unprognostic (5.44e-3)" 0.3 0.2 4.7 6.3 1.0 0.1 14.9 0.1 1.7 1.1 2.3 23.6 8.0 0.1 11.1 0.6 1.3 14.3 0.0 2.3 3.6 1.7 0.3 21.3 0.1 2.7 1.5 0.2 2.9 0.0 0.1 0.3 1.1 2.9 33.0 0.3 8.5 1.4 0.8 2.3 4.6 1.1 2.0 0.3 291.1 0.6 1.8 0.0 0.2 0.0 0.3 12.3 0.7 2.5 1.5 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.1 0.8 0.0 4.6 0.0 0.1 0.0 0.2 8.3 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.3 0.0 0.4 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 1.0 0.2 0.0 0.2 125.9 3.8 0.1 0.0 0.0 1.3 76.8 1.2 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.2 4.7 1.0 0.1 1.7 2.3 3.6 2.7 1.5 1.1 2.0 1.8 2.5 0.4 28.9 131.7 1.6 1.8 0.1 6.5 1.9 0.0 0.0 19.9 7.9 2.6 10.0 55.9 25.8 0.0 0.2 0.2 90.9 0.0 3.8 2.3 2.0 0.3 0.7 3.0 0.0 0.6 21.6 0.0 0.3 910.8 2.1 10.8 5.2 0.0 0.3 0.6 0.0 0.1 61.9 4.1 0.0 0.8 6.7 1.8 1.8 0.0 0.0 0.0 0.0 1.0 0.0 0.1 36.1 42.6 3.4 3.5 4.0 2.1 1.5 15.0 0.0 0.0 0.3 0.8 0.4 1.0 0.0 0.0 0.1 1.4 2.9 21.2 31.2 CAPN9 "GC36, nCL-4" ENSG00000135773 "Calpain 9" O14815 1 230747384-230802003 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 22.2;stomach 1: 60.3" "Group enriched" "Detected in some" 5 "Alveolar cells type 1: 25.6;Gastric mucus-secreting cells: 93.8;Intestinal goblet cells: 71.8" "Cancer enhanced" "Detected in many" "pancreatic cancer: 7.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "OE19: 10.7;SCLC-21H: 14.7" "Not detected" "Not detected" "Not detected" "Not detected" "HPA020398, CAB033483, HPA062050" Enhanced Approved "Golgi apparatus,Vesicles" NA NA "Cluster 4: Stomach - Digestion" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 27: Mucus-secreting cells - Mucin production" Vesicles "Golgi apparatus" "CAB033483: AB_1119945, HPA020398: AB_2670429, HPA062050: " "unprognostic (2.64e-1)" "unprognostic (1.20e-1)" "unprognostic (2.60e-2)" "unprognostic (1.09e-1)" "unprognostic (2.20e-1)" "unprognostic (2.49e-2)" "unprognostic (3.36e-2)" "unprognostic (2.30e-2)" "unprognostic (4.61e-2)" "unprognostic (3.44e-2)" "unprognostic (9.10e-2)" "unprognostic (1.60e-1)" "unprognostic (5.97e-5)" "unprognostic (1.51e-1)" "unprognostic (2.08e-1)" "unprognostic (4.60e-2)" "unprognostic (2.16e-1)" 0.0 0.6 1.4 0.9 2.2 0.0 0.4 1.3 1.2 0.4 0.0 13.7 6.6 0.2 0.5 0.2 2.5 0.6 0.4 1.1 1.4 0.0 0.0 7.5 0.0 2.1 1.7 0.6 0.2 1.0 0.0 0.0 1.8 0.6 22.2 5.0 11.3 0.1 0.2 0.1 11.7 0.5 1.9 0.0 60.3 0.2 1.7 0.1 0.1 0.1 0.0 2.0 0.1 3.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.6 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.3 0.1 0.0 0.5 10.7 0.0 0.4 0.0 0.0 0.0 0.1 14.7 0.0 0.0 0.4 0.0 0.1 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 2.2 1.3 1.2 1.1 1.4 2.1 1.7 1.8 1.9 1.7 3.4 0.0 25.6 3.0 0.3 0.1 0.0 0.6 0.7 0.0 0.0 0.6 0.3 6.0 0.0 3.2 0.0 0.0 0.1 0.0 4.1 0.0 0.2 5.2 1.5 0.1 0.1 3.0 0.0 0.4 0.2 0.0 0.4 93.8 0.5 2.5 0.1 0.0 0.0 0.1 0.0 0.4 71.8 0.0 0.0 0.0 11.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 3.6 1.7 5.0 0.0 0.2 0.5 3.3 0.1 8.2 1.7 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.1 0.0 2.1 1.5 CASP1 "ICE, IL1BC" ENSG00000137752 "Caspase 1" P29466 11 105025443-105035250 "Cancer-related genes, Enzymes, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 126.0;lymphoid tissue: 91.0" "Cell type enhanced" "Detected in many" "Kupffer cells: 125.3;Langerhans cells: 120.7;Macrophages: 136.6;monocytes: 185.6;Proximal enterocytes: 116.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+: 112.7;HBEC3-KT: 53.8;HHSteC: 58.2;U-937: 136.2" "Region enhanced" "Detected in all" "olfactory bulb: 18.4" "Low region specificity" "Detected in all" "CAB002685, HPA003056" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 14: B-cells - Humoral immune response" "Cluster 32: U-937 - Innate immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Cytosol Nucleoplasm "CAB002685: , HPA003056: AB_1846037" "unprognostic (1.21e-3)" "unprognostic (3.02e-1)" "unprognostic (9.47e-3)" "unprognostic (1.43e-1)" "unprognostic (1.47e-1)" "unprognostic (1.21e-1)" "unprognostic (5.24e-2)" "unprognostic (1.97e-1)" "unprognostic (1.66e-1)" "unprognostic (6.67e-2)" "unprognostic (2.75e-2)" "unprognostic (1.35e-1)" "prognostic unfavorable (3.11e-4)" "unprognostic (9.03e-2)" "unprognostic (2.30e-2)" "unprognostic (3.18e-1)" "unprognostic (5.19e-2)" 20.4 10.5 8.7 59.1 8.8 36.3 21.9 9.3 14.6 11.9 9.8 47.7 124.6 8.7 12.0 27.2 12.3 27.4 12.2 8.5 9.6 13.3 21.6 48.3 52.1 11.2 9.4 11.7 6.4 2.7 5.0 30.0 11.1 13.0 49.7 1.1 20.8 12.5 6.2 30.9 126.0 20.8 10.7 91.0 22.5 2.4 10.7 23.2 7.8 7.3 35.5 35.7 19.4 11.9 1.3 0.3 0.0 5.3 5.8 12.1 1.0 5.7 112.7 14.0 38.5 0.2 0.7 18.7 2.3 6.6 25.7 8.1 0.0 53.8 3.3 12.3 0.0 0.9 0.7 1.3 58.2 22.1 0.2 20.9 37.4 11.4 30.3 36.2 6.1 0.3 0.2 0.0 3.4 0.0 0.6 30.7 0.0 0.1 0.3 18.1 0.4 14.9 0.3 8.9 0.4 0.4 16.9 1.1 26.2 0.1 1.2 50.1 7.2 12.8 0.6 1.2 1.6 0.1 5.4 0.1 8.1 136.2 2.7 83.8 246.1 134.9 132.9 359.9 178.5 40.2 92.7 115.8 220.2 35.5 50.2 82.7 220.0 63.0 383.0 7.7 129.0 213.3 8.7 8.8 9.3 14.6 8.5 9.6 11.2 9.4 11.1 10.7 10.7 11.9 26.3 19.2 30.0 0.0 27.2 26.0 42.5 91.5 14.2 0.1 5.8 23.0 2.9 8.6 37.7 11.0 0.0 2.1 34.1 33.1 1.9 23.3 0.2 5.8 2.5 24.0 6.0 10.3 0.2 12.9 1.3 17.8 11.7 3.4 15.8 0.2 22.9 3.1 96.5 0.0 0.0 50.6 14.2 125.3 120.7 1.3 3.4 136.6 5.4 12.2 185.6 0.1 64.9 0.0 0.1 5.3 73.4 3.4 20.0 8.7 116.0 2.2 28.4 0.2 0.0 1.0 8.1 0.0 0.1 17.9 22.3 1.1 58.4 3.3 90.5 43.6 CASP10 "FLICE-2, MCH4" ENSG00000003400 "Caspase 10" Q92851 2 201182898-201229406 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 71.3;NK-cells: 44.3;Paneth cells: 44.5;Plasma cells: 49.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HUVEC TERT2: 25.3" "Low region specificity" "Detected in all" "CAB003780, HPA017059" Approved Approved "Golgi apparatus,Vesicles" NA NA "Cluster 24: B-cells - Unknown function" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 1: K-562 - Erythropoiesis" "Cluster 53: Intestinal epithelial cells - Unknown function" "Golgi apparatus" Vesicles "CAB003780: AB_289592, HPA017059: AB_1846040" "unprognostic (4.01e-2)" "unprognostic (8.24e-2)" "unprognostic (4.80e-1)" "unprognostic (1.28e-3)" "unprognostic (4.74e-2)" "unprognostic (2.25e-1)" "prognostic unfavorable (8.54e-4)" "unprognostic (1.73e-2)" "unprognostic (1.48e-2)" "unprognostic (3.68e-2)" "unprognostic (1.91e-1)" "unprognostic (1.04e-1)" "prognostic unfavorable (6.05e-7)" "unprognostic (3.23e-2)" "unprognostic (2.19e-2)" "unprognostic (4.49e-2)" "unprognostic (1.38e-2)" 8.8 2.4 5.7 9.2 5.5 19.5 6.5 4.5 5.8 4.0 4.4 13.2 21.8 3.3 6.2 8.8 5.4 7.4 6.7 4.7 5.1 8.1 6.2 11.5 8.9 6.0 5.0 1.6 4.8 2.3 1.3 9.6 5.8 3.9 13.4 1.3 5.4 3.1 4.9 5.7 18.4 5.1 5.6 22.6 10.2 1.2 7.3 8.7 5.3 2.8 10.4 9.0 5.1 5.4 4.4 3.5 0.3 0.4 0.1 0.3 7.5 0.7 4.6 0.4 1.8 4.6 9.8 0.5 7.0 2.5 1.7 2.9 0.2 2.3 1.3 2.1 4.8 12.2 4.0 15.1 1.6 8.3 12.7 0.5 2.0 5.3 0.4 0.3 25.3 5.1 14.9 17.4 0.4 0.3 15.9 7.8 0.6 6.0 2.4 8.8 0.5 18.4 8.7 6.2 0.2 0.1 4.1 0.2 1.9 3.0 0.2 7.8 10.0 0.4 0.8 3.4 0.2 18.7 12.1 0.5 4.5 6.3 0.2 5.9 11.7 0.7 6.4 16.5 5.6 8.2 5.2 3.6 6.5 7.7 7.2 6.4 2.1 8.5 19.3 6.6 1.2 7.2 5.7 5.5 4.5 5.8 4.7 5.1 6.0 5.0 5.8 5.6 7.3 5.4 20.7 19.2 10.0 0.3 15.8 6.0 2.7 10.6 5.2 0.0 1.3 0.9 1.8 8.6 9.4 9.2 0.0 1.1 20.5 71.3 1.9 16.2 1.2 7.7 7.4 29.7 2.4 14.9 0.3 10.4 0.7 4.2 26.5 12.0 7.6 0.8 26.4 7.1 9.4 0.0 0.5 21.6 4.1 26.6 17.5 0.0 0.6 16.2 7.2 33.7 22.0 0.5 44.3 0.0 0.9 8.6 44.5 0.0 49.7 2.5 26.1 8.7 24.4 0.4 0.0 2.9 2.2 0.1 0.1 6.6 4.5 0.4 12.9 4.1 16.4 10.3 CASP14 "MGC119078, MGC119079, MICE" ENSG00000105141 "Caspase 14" P31944 19 15049480-15058293 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Differentiation "Hydrolase, Protease, Thiol protease" Ichthyosis "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 24 "skin 1: 486.0" "Cell type enriched" "Detected in some" 5 "Suprabasal keratinocytes: 96.0" "Cancer enhanced" "Detected in many" "cervical cancer: 62.8" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 7 "hTCEpi: 49.0" "Not detected" "Not detected" "Not detected" "Not detected" "CAB010059, HPA027062" Enhanced Supported Nucleoplasm,Mitochondria,Cytosol NA NA 3600000 "Cluster 61: Skin - Cornification" "Cluster 30: Epithelial cell lines - Translation" "Cluster 28: Keratinocytes - Keratinization" "Nucleoplasm, Cytosol" Mitochondria "CAB010059: AB_626800, HPA027062: AB_2672101" "unprognostic (1.17e-2)" "unprognostic (6.44e-3)" "unprognostic (6.22e-2)" "unprognostic (2.77e-1)" "prognostic unfavorable (7.59e-4)" "unprognostic (9.42e-2)" "unprognostic (2.19e-2)" "prognostic unfavorable (5.96e-4)" "unprognostic (2.68e-1)" "unprognostic (4.30e-2)" "unprognostic (1.99e-1)" "unprognostic (1.97e-1)" 0.6 0.0 0.1 0.0 0.4 0.4 7.8 0.4 0.2 3.9 0.2 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.2 0.1 0.1 0.1 0.1 0.0 0.3 0.1 0.0 0.6 0.1 0.0 0.0 0.3 0.8 0.0 0.1 1.1 4.2 1.4 486.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 1.0 0.0 0.0 0.0 0.0 19.9 1.0 1.1 0.2 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 6.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 49.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.9 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.1 0.4 0.4 0.2 0.2 0.1 0.3 0.1 0.3 0.0 0.3 1.0 0.0 0.0 0.0 0.0 0.0 19.1 1.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 4.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.4 2.8 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 96.0 0.7 0.1 0.0 0.0 0.8 CASP2 "ICH1, MGC2181, NEDD2, PPP1R57" ENSG00000106144 "Caspase 2" P42575 7 143288215-143307696 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 51.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB012175, HPA050678" Approved Approved Nucleoplasm NA Yes "Cluster 38: Basophils - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 34: Spermatids - Unknown function" Nucleoplasm "CAB012175: , HPA050678: AB_2681214" "unprognostic (6.96e-2)" "prognostic favorable (7.38e-4)" "unprognostic (2.74e-2)" "unprognostic (7.51e-2)" "unprognostic (4.24e-2)" "unprognostic (2.39e-2)" "prognostic unfavorable (2.34e-4)" "unprognostic (1.74e-2)" "unprognostic (1.34e-2)" "prognostic favorable (2.89e-4)" "unprognostic (1.91e-2)" "unprognostic (1.64e-1)" "prognostic unfavorable (5.01e-6)" "unprognostic (2.66e-3)" "unprognostic (9.48e-2)" "unprognostic (1.19e-1)" "unprognostic (1.64e-1)" 10.3 6.6 6.0 13.9 6.7 40.2 10.5 7.8 6.7 11.8 6.7 11.1 10.7 10.2 9.6 15.3 10.3 7.0 8.4 5.9 6.2 9.1 6.4 10.4 22.0 7.2 6.4 9.3 8.4 11.1 5.3 12.4 7.7 7.6 12.7 7.7 11.9 6.3 3.9 17.4 15.4 9.4 5.9 19.0 9.6 9.1 6.9 27.5 8.8 5.0 27.1 7.5 11.2 10.0 27.5 25.4 28.8 51.0 15.1 17.5 15.4 27.7 13.0 25.4 27.8 26.0 31.3 52.0 25.9 18.4 19.4 27.3 29.4 22.6 34.0 45.8 22.5 31.2 40.4 18.3 8.4 60.7 37.4 13.0 18.1 31.0 11.0 11.3 22.0 41.3 26.3 32.6 27.5 27.5 109.1 64.4 36.5 27.4 26.3 79.1 14.6 32.6 15.1 23.3 31.5 34.2 54.8 24.3 17.3 19.6 26.3 23.4 24.1 22.5 15.5 40.7 28.1 27.0 28.5 59.4 24.9 72.6 41.1 69.2 17.9 17.2 24.5 21.7 24.2 25.7 33.3 25.3 17.3 28.8 24.3 28.3 21.7 24.2 34.1 21.1 38.9 15.3 6.0 6.7 7.8 6.7 5.9 6.2 7.2 6.4 7.7 5.9 6.9 10.0 14.1 9.6 8.3 4.2 17.4 15.2 7.0 9.4 6.2 4.8 19.0 13.5 6.2 17.2 7.0 7.3 8.4 20.0 19.3 8.7 3.9 8.1 36.6 10.8 17.9 16.4 10.7 9.7 11.2 7.7 14.6 9.3 8.2 20.1 10.1 22.7 18.2 7.2 10.1 6.7 8.8 11.5 0.0 16.9 23.3 51.0 11.8 12.2 21.4 4.7 20.8 4.4 13.4 4.5 22.4 9.4 5.9 8.2 13.0 5.8 9.1 4.2 4.9 15.4 0.0 8.3 10.9 13.7 25.9 16.1 13.8 5.7 16.7 9.3 15.5 7.0 CASP3 "apopain, CPP32, CPP32B, Yama" ENSG00000164305 "Caspase 3" P42574 4 184627696-184649509 "Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Plasma cells: 118.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 7 "basophil: 571.0;eosinophil: 408.6" "Lineage enriched" "Detected in all" 8 "granulocytes: 571.0" "Cell line enhanced" "Detected in all" "Karpas-707: 259.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000091, HPA002643, CAB008381" Enhanced Approved Nucleoplasm,Mitochondria NA NA 94000 "Cluster 2: Granulocytes - Unknown function" "Cluster 9: Intestine - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" Mitochondria Nucleoplasm "CAB000091: , CAB008381: AB_590737, HPA002643: AB_1846048" "unprognostic (1.38e-1)" "unprognostic (1.06e-1)" "unprognostic (2.21e-2)" "prognostic favorable (2.24e-4)" "unprognostic (2.29e-3)" "unprognostic (3.58e-2)" "unprognostic (9.57e-3)" "unprognostic (5.86e-2)" "unprognostic (3.56e-2)" "unprognostic (1.12e-2)" "unprognostic (1.70e-2)" "unprognostic (2.41e-1)" "prognostic unfavorable (2.30e-5)" "unprognostic (1.41e-2)" "unprognostic (5.74e-3)" "unprognostic (1.30e-1)" "unprognostic (4.05e-3)" 16.3 12.1 11.3 26.6 10.9 32.8 16.3 18.6 11.4 12.7 10.0 34.2 54.1 12.7 12.9 27.7 9.2 19.9 14.7 10.8 12.2 8.5 22.0 12.8 43.4 10.8 11.5 8.9 13.4 9.0 8.8 26.1 11.4 11.3 33.9 12.7 13.2 10.6 13.9 16.1 41.8 15.3 11.6 23.0 31.2 9.3 11.3 39.0 10.6 14.1 41.9 24.4 12.0 13.0 31.0 16.7 65.3 31.6 39.4 52.2 37.6 90.2 67.7 61.9 35.4 30.7 25.2 42.4 13.9 44.1 29.2 25.5 52.1 32.1 69.7 109.9 28.7 68.2 12.9 71.4 47.3 55.9 62.3 71.7 38.3 39.3 31.4 44.4 77.6 43.1 57.2 259.8 64.5 13.2 89.1 51.8 65.1 33.7 20.9 63.6 30.8 41.2 52.9 49.3 37.1 40.5 39.1 35.1 52.1 64.3 19.2 35.9 54.1 28.2 25.9 21.1 42.4 118.9 121.6 29.2 34.2 38.5 40.9 571.0 26.1 408.6 32.1 43.3 34.4 26.0 29.5 46.3 33.3 18.6 22.2 32.8 35.6 62.0 71.0 26.5 64.1 47.5 11.3 10.9 18.6 11.4 10.8 12.2 10.8 11.5 11.4 11.6 11.3 13.0 28.6 19.2 15.8 26.4 32.3 48.7 22.2 34.1 35.9 18.6 21.7 17.0 17.5 5.7 36.3 12.9 0.0 46.9 54.8 37.4 13.7 18.4 9.6 24.9 17.1 26.6 18.0 62.3 9.6 23.7 33.6 19.5 24.5 24.9 17.7 24.8 21.0 15.3 23.9 13.5 12.6 37.6 44.7 27.0 17.4 4.0 7.5 33.3 30.2 13.1 41.5 15.4 37.0 11.1 18.4 25.0 18.8 7.5 118.6 20.1 26.6 8.4 30.4 11.3 13.1 19.0 20.8 7.9 16.4 34.6 28.6 51.4 43.8 23.1 24.4 36.7 CASP4 "ICE(rel)II, ICH-2, TX" ENSG00000196954 "Caspase 4" P49662 11 104942866-104969366 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Immunity, Inflammatory response, Innate immunity, Necrosis" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "HPA027588, CAB037167" Approved Approved "Plasma membrane,Cytosol" "Intracellular and membrane" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 64: Macrophages - Immune response" "Cluster 30: Epithelial cell lines - Translation" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "Plasma membrane" "CAB037167: AB_258864, HPA027588: AB_10603781" "unprognostic (1.19e-2)" "unprognostic (3.73e-1)" "unprognostic (3.44e-1)" "unprognostic (1.99e-2)" "unprognostic (7.19e-3)" "unprognostic (2.63e-2)" "unprognostic (1.26e-2)" "unprognostic (1.56e-2)" "unprognostic (5.31e-2)" "unprognostic (2.71e-1)" "unprognostic (2.38e-3)" "unprognostic (8.39e-3)" "prognostic unfavorable (3.27e-11)" "unprognostic (6.75e-2)" "unprognostic (1.34e-1)" "unprognostic (1.79e-2)" "unprognostic (4.08e-3)" 45.7 21.7 7.0 69.4 7.2 48.5 44.4 7.4 12.4 26.4 8.6 27.6 62.4 18.4 33.1 47.7 34.9 50.1 17.8 7.5 8.0 33.3 54.1 61.3 80.2 9.7 8.1 43.2 52.5 4.7 11.0 70.2 8.7 21.7 30.7 2.0 55.2 15.5 7.5 46.7 58.8 32.2 8.3 71.1 42.4 4.9 9.0 57.2 15.6 18.1 82.1 76.5 30.5 8.7 33.8 9.5 0.0 12.9 58.2 140.4 27.8 68.0 103.2 80.5 117.0 22.4 128.5 22.3 123.1 71.5 110.4 52.7 0.0 94.3 78.8 22.4 0.4 53.1 7.4 55.8 158.2 48.5 19.2 122.6 127.0 97.9 144.4 104.7 143.8 0.5 1.3 0.0 64.4 2.8 26.1 46.7 0.0 71.6 28.2 21.4 21.5 14.2 64.9 46.2 0.6 0.4 60.8 31.6 49.3 0.7 11.9 62.5 93.2 84.4 30.4 80.8 40.5 0.0 0.0 0.3 42.2 105.5 63.4 136.4 292.0 50.6 208.9 312.9 224.8 141.9 155.6 193.9 205.5 144.4 93.4 138.5 667.2 226.2 255.4 35.4 257.9 410.9 7.0 7.2 7.4 12.4 7.5 8.0 9.7 8.1 8.7 8.3 9.0 8.7 78.1 60.9 60.8 0.3 87.4 55.8 63.3 130.1 21.1 0.0 40.8 48.4 5.6 47.1 107.0 22.0 0.0 129.1 80.4 12.4 15.6 157.5 0.6 35.9 27.7 73.0 20.9 12.4 0.0 189.9 103.0 53.6 33.1 45.7 34.8 32.6 82.1 34.7 116.7 0.0 0.2 37.8 73.2 168.0 81.2 2.1 29.2 105.2 30.2 23.4 141.5 1.9 177.1 1.5 0.2 148.5 8.6 20.7 50.5 31.1 85.4 41.1 86.1 0.4 6.6 38.1 34.2 0.2 0.5 25.8 45.9 115.9 102.1 36.8 32.9 80.0 CASP5 ICE(rel)III ENSG00000137757 "Caspase 5" P51878 11 104994235-105023168 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 5.0;intestine: 16.8;lymphoid tissue: 14.6" "Cell type enhanced" "Detected in some" "Distal enterocytes: 31.4;Paneth cells: 18.7;Proximal enterocytes: 17.2;Undifferentiated cells: 7.3" "Group enriched" "Detected in some" 7 "colorectal cancer: 3.9;stomach cancer: 1.3" "Region enhanced" "Detected in some" "cerebral cortex: 5.0" "Group enriched" "Detected in some" 13 "intermediate monocyte: 18.1;neutrophil: 13.0;non-classical monocyte: 41.2" "Group enriched" "Detected in many" 15 "granulocytes: 13.0;monocytes: 41.2" "Cell line enriched" "Detected in single" 6 "HHSteC: 3.7" NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 9: Intestine - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 53: Intestinal epithelial cells - Unknown function" "unprognostic (4.30e-2)" "unprognostic (8.86e-2)" "unprognostic (1.07e-1)" "unprognostic (4.74e-2)" "unprognostic (1.66e-1)" "unprognostic (5.22e-2)" "unprognostic (9.90e-2)" "unprognostic (8.29e-3)" "unprognostic (1.47e-1)" "unprognostic (4.38e-3)" "unprognostic (7.39e-3)" "unprognostic (3.25e-1)" "unprognostic (1.82e-9)" "unprognostic (7.30e-2)" "unprognostic (2.67e-3)" "unprognostic (1.87e-1)" "unprognostic (1.50e-1)" 0.7 0.1 0.5 14.6 0.6 0.2 0.1 0.5 5.0 0.2 0.6 15.6 10.0 0.1 0.2 0.1 0.2 0.4 0.1 0.5 0.5 0.2 0.2 1.6 0.9 0.7 0.8 0.1 0.0 0.0 0.1 0.9 1.5 0.1 12.9 0.0 0.1 0.1 0.0 0.0 16.8 1.8 0.6 2.7 0.1 0.3 0.8 0.1 0.1 0.4 0.3 2.2 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.3 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 3.7 0.0 0.0 0.1 0.4 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 18.1 0.1 0.1 0.0 0.0 1.8 0.0 0.0 0.1 13.0 0.0 41.2 0.5 0.0 1.4 0.5 0.6 0.5 5.0 0.5 0.5 0.7 0.8 1.5 0.6 0.8 0.9 0.0 3.2 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 31.4 0.0 2.3 0.7 0.0 0.0 0.1 0.0 0.0 0.1 0.2 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 5.3 0.0 4.7 0.4 0.7 0.0 4.8 0.0 1.9 2.4 0.0 0.0 0.0 0.1 0.1 18.7 0.0 0.0 0.0 17.2 0.0 0.8 0.0 0.0 0.2 0.1 0.5 0.7 0.0 0.0 0.0 0.3 0.0 7.3 0.1 CASP6 MCH2 ENSG00000138794 "Caspase 6" P55212 4 109688622-109703583 "Cancer-related genes, Enzymes, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 40.8" "Cell type enhanced" "Detected in many" "Granulosa cells: 112.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Karpas-707: 76.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003775, HPA011337, HPA024303" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 20: T-cells - T-cell receptor" "Cluster 9: Intestine - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 40: Granulosa cells - Unknown function" Cytosol Nucleoplasm "CAB003775: AB_562064, HPA011337: AB_1846053, HPA024303: AB_1846052" "unprognostic (1.07e-1)" "unprognostic (1.91e-1)" "prognostic favorable (2.64e-5)" "unprognostic (1.45e-2)" "unprognostic (1.90e-1)" "unprognostic (1.46e-1)" "unprognostic (3.03e-3)" "unprognostic (9.87e-2)" "unprognostic (2.73e-2)" "unprognostic (2.59e-3)" "unprognostic (1.15e-2)" "unprognostic (6.78e-2)" "unprognostic (2.44e-1)" "unprognostic (8.74e-3)" "unprognostic (2.18e-1)" "unprognostic (2.41e-1)" "prognostic favorable (9.93e-4)" 6.5 6.7 3.9 8.4 4.0 10.8 10.5 4.3 5.4 7.6 4.0 35.3 40.8 7.7 5.1 7.4 7.6 9.3 5.6 3.8 4.0 11.5 18.1 7.8 9.6 3.7 3.7 8.3 13.3 4.8 4.2 4.8 3.8 9.1 31.5 3.0 8.6 6.5 3.3 10.7 36.8 7.4 3.8 8.0 15.8 1.8 3.7 11.5 8.5 2.4 7.7 8.1 7.0 4.3 26.6 8.4 16.5 14.8 11.0 11.2 24.3 15.3 9.2 12.4 13.4 13.8 50.3 2.7 16.4 14.7 17.3 12.1 19.7 21.8 8.4 43.5 13.0 22.8 7.1 12.9 9.4 23.5 15.7 12.6 15.1 12.4 2.8 17.1 22.9 30.1 29.9 76.1 19.2 13.7 62.0 14.4 12.7 17.1 16.1 20.5 10.8 13.3 39.6 24.8 17.2 13.2 15.0 25.7 8.8 19.6 11.0 8.0 20.3 12.8 14.6 6.6 16.7 11.4 23.0 2.8 17.1 26.9 7.1 16.3 6.9 8.9 6.3 6.9 7.0 6.1 23.8 12.3 8.8 8.6 28.0 16.1 1.4 7.5 11.2 11.6 24.8 9.4 3.9 4.0 4.3 5.4 3.8 4.0 3.7 3.7 3.8 3.8 3.7 4.3 10.5 16.0 14.6 5.2 7.7 10.8 10.2 26.7 12.0 6.9 23.6 16.0 4.1 28.6 23.2 20.2 6.2 20.9 7.6 54.0 9.8 40.8 2.6 19.8 9.5 12.2 59.2 19.7 6.4 46.4 41.1 13.4 18.3 23.3 10.1 112.3 9.7 20.4 19.8 0.0 7.3 53.9 32.6 8.7 9.3 1.7 12.8 14.5 1.8 2.8 17.9 16.0 6.2 5.5 5.8 45.9 52.5 9.8 8.8 7.4 71.7 35.7 18.6 1.3 6.6 7.6 12.3 1.9 8.6 10.8 11.6 5.7 17.5 12.4 74.2 8.0 CASP7 "CMH-1, ICE-LAP3, MCH3" ENSG00000165806 "Caspase 7" P55210 10 113679162-113730907 "Cancer-related genes, Enzymes, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 229.1;Paneth cells: 113.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" CAB025563 Enhanced NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 9: Intestine - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB025563: " "prognostic favorable (2.11e-4)" "unprognostic (3.18e-2)" "unprognostic (2.82e-2)" "unprognostic (2.18e-1)" "unprognostic (2.85e-1)" "unprognostic (1.33e-1)" "unprognostic (2.63e-3)" "unprognostic (3.96e-1)" "unprognostic (2.04e-1)" "unprognostic (1.22e-2)" "unprognostic (1.07e-1)" "unprognostic (2.35e-2)" "prognostic unfavorable (5.90e-4)" "unprognostic (5.45e-3)" "unprognostic (2.62e-1)" "unprognostic (2.86e-1)" "unprognostic (4.33e-3)" 21.0 10.3 11.8 26.2 12.2 8.4 18.6 11.5 20.4 18.4 12.8 75.1 65.3 16.3 10.5 15.4 17.9 16.8 11.3 11.8 12.0 19.6 23.6 24.9 16.9 12.3 12.5 16.2 22.4 10.4 7.0 20.9 11.9 21.3 58.2 6.8 34.1 12.3 13.8 17.4 68.1 18.5 11.4 17.5 45.5 6.8 12.8 19.8 10.2 14.5 18.4 31.6 16.1 12.8 28.9 29.4 24.1 13.0 43.4 37.5 16.7 32.9 49.9 56.1 69.7 22.4 51.0 30.1 19.0 29.8 21.1 24.8 30.4 24.2 39.5 46.9 41.0 19.6 22.0 38.0 28.9 20.9 24.7 24.5 15.9 32.0 13.3 25.0 75.4 28.2 5.3 39.8 21.1 38.2 51.1 16.0 4.4 31.7 17.3 51.7 98.0 18.1 44.8 21.4 1.9 14.4 24.9 35.5 17.6 23.1 43.1 18.4 37.8 12.8 24.1 13.5 27.7 30.7 20.1 0.8 13.1 38.7 14.3 22.9 14.7 11.7 11.1 21.3 9.5 11.5 9.2 14.1 10.4 9.2 7.1 9.7 2.6 7.4 18.5 1.4 14.0 9.8 11.8 12.2 11.5 20.4 11.8 12.0 12.3 12.5 11.9 11.4 12.8 12.8 36.3 9.6 12.3 27.4 13.8 19.8 21.2 26.0 13.1 0.6 15.8 9.9 2.5 11.5 26.2 22.0 0.0 12.4 10.3 229.1 11.7 46.1 0.3 21.0 22.9 23.8 9.6 4.0 1.6 39.0 25.5 16.2 30.1 13.5 12.7 10.9 17.2 15.6 17.0 0.0 1.1 81.1 28.5 12.8 6.9 0.6 9.6 18.4 7.2 10.3 68.9 7.9 13.4 1.0 0.8 37.2 113.4 4.1 21.5 42.6 88.0 25.9 42.8 1.7 19.7 12.3 16.3 2.9 28.2 13.3 14.8 10.9 15.7 5.2 50.7 39.0 CASP8 "Casp-8, FLICE, MACH, MCH5" ENSG00000064012 "Caspase 8" Q14790 2 201233443-201287711 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Host-virus interaction" "Hydrolase, Protease, Thiol protease" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 66.6" "Cell type enhanced" "Detected in many" "dendritic cells: 107.4;NK-cells: 132.8;Plasma cells: 73.4;T-cells: 86.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA001302, CAB002047, HPA005688, HPA006191" Approved Supported Nucleoplasm,Cytosol No No "Cluster 5: Granulocytes - Unknown function" "Cluster 2: Immune cells - Immune response" "Cluster 29: U-266 - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" Cytosol Nucleoplasm "CAB002047: AB_563465, HPA001302: AB_1846057, HPA005688: AB_1846056, HPA006191: AB_2667535" "unprognostic (5.21e-3)" "unprognostic (2.10e-1)" "unprognostic (1.83e-2)" "unprognostic (9.69e-3)" "unprognostic (2.09e-1)" "unprognostic (5.60e-2)" "prognostic unfavorable (3.02e-4)" "unprognostic (2.10e-1)" "unprognostic (4.79e-2)" "prognostic favorable (1.25e-4)" "unprognostic (7.75e-2)" "unprognostic (5.11e-2)" "prognostic unfavorable (1.27e-6)" "unprognostic (7.67e-3)" "unprognostic (2.43e-1)" "unprognostic (2.53e-1)" "unprognostic (4.53e-3)" 11.5 10.2 1.7 28.6 2.0 66.6 13.9 1.3 2.1 9.6 4.2 16.1 20.5 8.5 13.2 12.9 14.1 13.2 5.2 2.1 1.8 10.7 14.1 19.6 37.7 3.4 3.0 7.7 7.8 2.9 3.4 9.9 2.7 6.9 17.6 4.6 8.4 7.3 3.3 12.1 26.0 9.9 2.4 37.1 15.9 4.3 2.6 24.4 7.9 3.0 29.7 18.0 8.6 2.4 33.6 26.6 7.7 22.2 20.7 29.7 12.0 13.8 13.2 16.0 26.2 36.1 54.9 3.7 29.6 10.7 28.7 16.2 17.2 16.1 31.3 21.1 15.4 31.0 21.9 35.1 17.1 25.6 33.8 25.9 38.0 30.1 23.9 13.4 15.1 26.9 28.6 69.1 14.7 13.1 32.1 25.9 12.6 17.5 23.7 24.7 15.9 55.4 30.8 35.3 2.3 1.1 17.9 29.8 18.0 7.0 8.0 19.1 19.6 17.3 18.0 9.0 10.9 63.1 30.2 21.2 25.3 33.1 16.6 76.1 39.5 77.1 70.7 51.2 66.0 40.9 57.8 75.9 41.6 24.0 37.0 47.2 153.6 70.6 51.5 18.6 75.0 40.6 1.7 2.0 1.3 2.1 2.1 1.8 3.4 3.0 2.7 2.4 2.6 2.4 8.5 25.6 26.7 0.7 50.0 7.5 13.0 6.1 10.2 2.1 12.9 9.3 2.5 10.0 13.0 5.5 10.4 8.5 107.4 37.0 15.6 12.3 5.9 25.6 8.1 10.1 4.2 10.5 2.5 8.4 12.1 9.5 19.4 27.2 24.6 10.4 5.3 11.7 11.9 0.0 1.3 15.2 4.1 25.3 15.7 1.9 2.5 25.0 7.2 10.3 35.6 0.2 132.8 1.0 0.5 11.2 30.1 0.7 73.4 9.7 22.3 23.6 14.2 0.4 0.0 4.5 3.7 0.8 0.4 13.1 7.7 3.4 86.9 10.6 17.4 12.7 CASP9 "APAF-3, ICE-LAP6, MCH6, PPP1R56" ENSG00000132906 "Caspase 9" P55211 1 15490832-15526534 "Cancer-related genes, Enzymes, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Syncytiotrophoblasts: 35.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001473, CAB004348, HPA046488" Approved Approved Mitochondria NA NA "Cluster 46: Basophils - DNA binding" "Cluster 35: Non-specific - Unknown function" "Cluster 20: HeLa - Mitochondria" "Cluster 41: Macrophages - Immune response" Mitochondria "CAB004348: AB_673489, HPA001473: AB_1078401, HPA046488: AB_2679670" "prognostic favorable (5.91e-4)" "unprognostic (2.42e-1)" "unprognostic (8.94e-3)" "unprognostic (7.84e-2)" "unprognostic (1.93e-2)" "unprognostic (8.54e-3)" "unprognostic (1.90e-3)" "unprognostic (6.75e-2)" "unprognostic (2.58e-1)" "unprognostic (1.29e-1)" "unprognostic (9.09e-2)" "unprognostic (1.98e-1)" "unprognostic (1.39e-2)" "unprognostic (2.35e-1)" "unprognostic (3.21e-2)" "unprognostic (5.48e-2)" "prognostic favorable (1.67e-5)" 12.0 50.8 14.1 7.0 14.5 11.5 8.9 16.1 18.8 19.3 13.3 11.8 6.4 14.4 12.5 14.1 22.5 9.4 16.4 14.2 13.0 20.7 14.8 10.8 6.9 14.8 14.2 57.6 37.8 12.0 32.4 7.1 14.1 19.2 5.3 12.3 8.9 9.8 12.7 5.5 11.0 6.6 13.6 10.6 12.4 25.9 14.6 8.7 25.9 9.4 7.9 12.9 12.8 17.1 10.4 17.8 4.6 8.9 11.0 5.4 5.3 7.5 9.9 11.1 12.7 12.5 10.1 13.4 16.2 7.5 13.1 4.2 10.5 8.2 11.7 5.9 11.6 9.8 32.8 10.8 10.8 10.6 11.5 9.7 11.5 15.3 3.8 8.3 8.7 13.3 20.4 13.4 5.8 5.2 3.3 8.6 5.9 11.3 8.2 7.4 13.4 16.4 12.3 6.7 4.4 9.0 9.6 1.8 15.6 12.1 5.7 7.9 4.8 13.8 5.8 15.6 5.1 13.3 21.5 16.3 8.9 9.9 5.0 54.2 24.7 54.8 11.0 17.4 8.2 21.3 6.6 7.6 25.1 30.0 3.1 4.8 36.3 29.3 18.9 11.4 6.9 15.0 14.1 14.5 16.1 18.8 14.2 13.0 14.8 14.2 14.1 13.6 14.6 17.1 2.8 3.2 3.7 18.3 17.1 2.9 8.2 5.0 4.6 3.2 7.0 4.7 9.3 11.5 7.3 18.4 6.2 17.0 8.0 7.0 1.9 7.5 12.6 10.9 5.2 3.3 3.0 5.7 7.9 9.1 10.8 5.6 12.8 7.6 1.3 5.7 4.2 4.7 9.5 5.0 9.9 6.3 6.1 4.8 12.9 5.5 2.1 12.9 0.0 6.5 4.8 7.5 10.3 9.5 8.8 8.4 7.3 3.8 9.9 4.0 9.8 7.2 8.9 6.3 0.0 5.3 9.7 16.4 7.1 6.0 2.4 35.7 6.4 7.9 5.6 7.4 CFLAR "c-FLIP, CASH, CASP8AP1, Casper, cFLIP, CLARP, FLAME, FLIP, I-FLICE, MRIT" ENSG00000003402 "CASP8 and FADD like apoptosis regulator" O15519 2 201116154-201176687 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Apoptosis, Host-virus interaction" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Langerhans cells: 609.9;Urothelial cells: 521.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 4 "neutrophil: 392.6" "Lineage enriched" "Detected in all" 6 "granulocytes: 392.6" "Cell line enhanced" "Detected in all" "U-266/70: 214.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019044, CAB022157, CAB025216" Uncertain Supported "Nucleoplasm,Nuclear bodies,Plasma membrane,Cytosol" NA Yes "Cluster 50: Neutrophils - Cellular senescence" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 41: Macrophages - Immune response" "Nucleoplasm, Plasma membrane, Cytosol" "Nuclear bodies" "CAB022157: , CAB025216: , HPA019044: AB_10696204" "unprognostic (4.61e-2)" "unprognostic (5.32e-2)" "unprognostic (2.49e-1)" "unprognostic (1.44e-1)" "unprognostic (2.95e-2)" "prognostic favorable (2.79e-4)" "unprognostic (7.46e-2)" "unprognostic (9.01e-2)" "unprognostic (1.76e-1)" "unprognostic (6.12e-2)" "unprognostic (3.08e-2)" "unprognostic (4.91e-2)" "unprognostic (2.90e-2)" "unprognostic (7.83e-2)" "unprognostic (9.13e-2)" "unprognostic (6.84e-2)" "unprognostic (2.24e-2)" 122.4 50.6 38.8 103.9 40.9 247.6 83.1 54.1 47.4 57.0 75.6 86.0 59.2 57.9 60.6 68.0 66.6 71.6 184.8 39.4 32.7 57.5 59.2 174.6 91.1 46.5 40.5 38.3 40.7 31.8 29.4 94.0 42.1 65.6 56.4 12.4 58.0 63.2 222.8 51.0 64.8 58.8 36.6 98.1 56.5 25.3 51.9 54.1 78.8 89.2 107.3 78.7 61.7 46.1 21.5 42.9 30.0 17.9 92.3 71.0 37.5 53.6 92.1 34.3 41.6 50.4 78.4 5.8 49.6 62.5 41.6 15.5 9.8 40.3 53.9 160.7 29.9 32.3 38.4 82.2 63.6 24.2 102.2 76.8 39.6 58.2 50.3 41.7 176.7 7.3 110.8 131.2 63.1 17.9 11.3 96.3 10.2 17.2 32.7 11.7 7.2 46.5 42.5 44.0 6.6 11.8 35.7 31.2 43.2 19.6 22.1 44.8 193.6 71.0 29.5 26.7 26.1 214.6 76.2 35.9 50.6 19.5 36.3 91.8 60.3 70.3 54.4 61.8 48.4 25.6 46.5 52.1 33.4 20.9 29.5 38.3 392.6 45.2 68.5 23.0 60.7 42.0 38.8 40.9 54.1 47.4 39.4 32.7 46.5 40.5 42.1 36.6 51.9 46.1 191.3 451.9 234.9 30.3 126.4 54.8 229.6 164.9 29.0 10.9 38.9 30.0 205.8 102.9 206.7 69.9 31.3 77.2 166.2 132.5 74.3 148.8 83.3 202.8 75.0 261.0 95.1 59.1 6.9 72.5 34.8 89.5 73.4 219.2 81.6 93.4 201.0 97.5 68.6 13.5 16.8 76.8 40.7 123.2 609.9 44.8 51.9 278.0 97.8 146.1 247.0 23.4 276.0 29.7 56.8 166.4 155.6 49.7 317.8 386.0 116.7 101.5 276.1 30.7 39.5 113.2 77.9 14.4 12.2 33.2 86.1 70.1 168.3 56.1 50.9 521.3 CTSB ENSG00000164733 "Cathepsin B" P07858 8 11842524-11869533 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hofbauer cells: 2744.5;Kupffer cells: 1774.9;Macrophages: 1224.3" "Cancer enriched" "Detected in all" 5 "thyroid cancer: 1446.9" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 4 "basophil: 390.6;classical monocyte: 610.1;intermediate monocyte: 467.3;myeloid DC: 287.4;non-classical monocyte: 307.6;plasmacytoid DC: 410.1" "Group enriched" "Detected in all" 6 "dendritic cells: 410.1;granulocytes: 390.6;monocytes: 610.1" "Cell line enhanced" "Detected in all" "BJ hTERT+: 1607.5;fHDF/TERT166: 1436.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000457, HPA018156, HPA048998" Enhanced Supported Nucleoli,Vesicles "Secreted to blood" NA NA 100000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 72: Non-specific - Transcription" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 4: Macrophages - Innate immune response" Vesicles Nucleoli "CAB000457: , HPA018156: AB_1846069, HPA048998: " "unprognostic (5.74e-2)" "unprognostic (4.32e-2)" "unprognostic (1.38e-2)" "unprognostic (2.17e-2)" "unprognostic (2.98e-3)" "unprognostic (5.96e-2)" "unprognostic (1.36e-2)" "unprognostic (1.07e-1)" "unprognostic (2.82e-2)" "unprognostic (1.06e-1)" "unprognostic (7.61e-2)" "unprognostic (8.30e-2)" "unprognostic (2.85e-1)" "unprognostic (7.39e-2)" "unprognostic (4.12e-2)" "prognostic favorable (5.76e-4)" "prognostic unfavorable (9.02e-4)" 443.9 304.5 65.6 399.7 71.2 87.0 249.0 65.9 77.2 583.2 101.0 312.4 120.8 379.2 116.9 421.6 368.4 230.6 447.0 64.7 95.5 420.6 497.2 428.9 289.6 100.4 90.8 169.1 135.4 79.6 156.8 253.2 107.4 255.5 159.3 33.6 437.3 156.6 237.4 184.7 260.2 316.1 91.9 521.1 194.3 33.2 204.5 60.9 1150.7 99.3 104.0 431.9 477.8 159.2 66.6 283.4 4.0 94.9 657.3 754.5 128.3 885.0 1607.5 258.4 299.5 10.3 294.4 1.5 32.2 1436.1 419.3 279.5 65.3 157.1 195.6 25.9 52.6 58.8 10.0 397.1 479.2 7.7 73.7 296.4 532.2 327.2 427.3 611.5 33.4 20.2 81.7 260.7 194.6 62.5 6.5 23.1 16.3 839.7 91.3 33.6 39.3 202.7 2.6 121.1 4.9 68.6 165.1 68.6 514.6 110.1 97.8 68.7 922.4 766.5 111.9 129.9 259.3 182.7 178.5 4.8 432.5 22.9 249.4 390.6 610.1 90.6 26.3 467.3 35.4 44.1 79.0 31.5 287.4 38.8 48.3 21.5 97.8 31.3 307.6 410.1 78.7 703.7 65.6 71.2 65.9 77.2 64.7 95.5 100.4 90.8 107.4 91.9 204.5 159.2 87.7 109.0 171.4 17.6 54.8 54.7 441.6 563.2 54.7 55.2 94.1 74.5 320.1 165.8 331.7 114.0 41.7 279.4 122.4 147.9 27.4 294.6 15.6 105.8 240.1 163.0 154.7 210.2 36.2 238.2 341.7 155.0 44.4 183.5 179.4 105.9 204.2 239.5 2744.5 58.9 42.8 94.2 158.7 1774.9 436.5 18.5 76.4 1224.3 161.9 70.3 373.1 117.4 24.7 19.1 12.9 363.9 154.0 92.9 47.3 295.5 198.6 351.8 180.8 40.0 39.5 39.4 149.9 10.8 21.0 160.3 40.5 649.6 56.0 32.1 139.6 321.4 CTSC "DPP1, PALS, PLS" ENSG00000109861 "Cathepsin C" P53634 11 88265069-88359684 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Thiol protease" "Disease variant, Palmoplantar keratoderma" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 900.7;Club cells: 471.8;Hofbauer cells: 1100.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "BJ hTERT+: 1078.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025364, HPA066610, HPA068434" Enhanced Supported Vesicles "Intracellular and membrane" No No 19000000 "Cluster 51: Monocytes - Innate immune response" "Cluster 19: Lung - Lung function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Vesicles "CAB025364: , HPA066610: AB_2685694, HPA068434: AB_2685989" "unprognostic (4.05e-2)" "unprognostic (1.35e-1)" "unprognostic (1.50e-1)" "unprognostic (1.10e-1)" "unprognostic (3.70e-2)" "unprognostic (1.45e-2)" "prognostic unfavorable (9.30e-5)" "unprognostic (1.62e-1)" "unprognostic (1.04e-1)" "unprognostic (1.56e-2)" "unprognostic (3.11e-2)" "unprognostic (3.35e-1)" "prognostic favorable (4.80e-4)" "unprognostic (2.93e-1)" "unprognostic (4.35e-2)" "unprognostic (8.10e-2)" "unprognostic (4.07e-2)" 173.2 60.7 9.9 185.1 9.6 71.7 63.4 11.1 24.9 77.9 14.2 143.1 121.0 43.9 28.5 63.3 54.0 182.0 38.5 9.5 10.1 234.7 82.0 272.6 243.7 14.0 11.9 22.1 52.2 42.4 39.3 253.3 13.3 26.0 191.5 3.7 131.6 28.9 18.8 29.6 128.8 88.9 11.5 197.2 73.6 22.8 19.5 63.7 43.6 31.9 140.6 176.3 43.3 21.3 80.3 75.9 27.6 69.9 103.7 286.1 218.4 626.5 1078.4 372.8 270.3 194.7 361.3 117.3 278.9 365.2 84.3 133.6 50.4 269.2 341.9 204.7 82.8 144.5 188.0 233.5 140.2 188.9 108.7 419.1 198.8 284.5 697.4 302.1 377.6 122.3 155.3 145.4 54.8 14.8 89.1 295.1 172.2 551.5 244.9 113.6 30.7 227.0 451.3 106.6 8.8 66.8 81.2 114.9 80.6 185.4 27.9 152.7 149.3 23.5 190.5 156.8 364.6 61.9 81.0 122.9 56.8 435.8 122.4 85.5 203.8 309.7 230.1 415.6 194.9 47.2 99.6 198.2 209.9 26.3 49.5 115.3 215.0 200.5 582.9 425.0 162.7 243.3 9.9 9.6 11.1 24.9 9.5 10.1 14.0 11.9 13.3 11.5 19.5 21.3 78.6 22.4 88.1 0.3 40.8 30.1 7.3 900.7 33.6 1.5 15.9 14.6 4.4 52.9 471.8 40.5 0.0 414.1 330.6 37.9 29.4 29.8 1.6 13.4 135.6 94.8 11.4 29.7 3.0 90.6 159.2 114.4 39.8 21.2 75.3 25.5 26.4 15.8 1100.6 0.0 8.2 19.4 158.7 344.7 200.7 7.9 198.5 391.7 48.0 61.8 185.4 0.5 299.7 13.6 0.4 44.8 72.3 25.6 78.5 8.5 20.2 166.4 93.7 0.8 59.2 4.4 150.8 3.0 11.1 43.3 27.1 227.3 170.6 286.7 44.9 16.1 CTSF "CATSF, CLN13" ENSG00000174080 "Cathepsin F" Q9UBX1 11 66563464-66568879 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Disease variant, Neurodegeneration, Neuronal ceroid lipofuscinosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Late spermatids: 320.9;Muller glia cells: 196.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "SiHa: 23.1;SK-MEL-30: 59.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002141, HPA031431" Approved Supported "Endoplasmic reticulum,Vesicles,Plasma membrane" "Intracellular and membrane" NA NA 5800000 "Cluster 15: NK-cells - Transcription" "Cluster 35: Non-specific - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 5: Muller glia cells - Visual perception" Vesicles "Endoplasmic reticulum, Plasma membrane" "CAB002141: AB_563471, HPA031431: " "unprognostic (1.52e-2)" "unprognostic (1.08e-1)" "unprognostic (1.03e-1)" "unprognostic (7.22e-3)" "unprognostic (2.25e-2)" "unprognostic (6.72e-2)" "unprognostic (2.67e-2)" "unprognostic (2.76e-2)" "unprognostic (3.69e-1)" "unprognostic (4.14e-1)" "unprognostic (1.69e-2)" "unprognostic (9.12e-2)" "prognostic favorable (8.92e-7)" "unprognostic (1.36e-2)" "unprognostic (1.28e-1)" "unprognostic (3.89e-1)" "unprognostic (2.42e-1)" 57.8 70.0 68.1 0.8 76.3 0.3 62.2 74.5 74.0 78.8 90.2 76.7 3.0 89.2 21.9 15.6 70.8 10.0 100.2 63.2 74.2 46.9 66.0 32.9 3.6 75.0 70.3 99.1 31.7 20.0 43.3 3.8 68.4 53.5 3.5 26.2 55.7 17.1 91.9 44.4 29.5 12.2 77.2 25.0 54.3 109.7 71.0 3.0 40.6 27.6 3.0 56.6 58.7 86.6 0.0 17.0 3.1 5.4 14.2 8.6 3.4 13.0 11.4 6.3 2.3 0.0 2.2 0.0 21.3 10.4 0.0 1.2 6.8 2.6 4.8 3.7 0.0 0.5 7.0 0.0 9.9 0.3 4.4 22.3 9.1 0.8 1.6 13.7 3.8 2.0 5.4 1.6 5.2 4.6 0.1 1.7 0.9 3.7 9.7 0.0 0.0 1.5 7.1 0.3 4.3 6.9 23.1 0.3 59.5 0.3 7.4 0.6 3.3 1.8 2.9 1.5 1.2 21.2 0.2 0.0 2.2 0.0 2.9 0.0 0.4 0.3 3.9 0.6 4.1 1.5 3.5 4.6 0.6 1.4 6.4 4.1 0.1 4.6 0.2 0.9 1.3 2.2 68.1 76.3 74.5 74.0 63.2 74.2 75.0 70.3 68.4 77.2 71.0 86.6 36.6 12.8 15.6 31.3 5.9 39.8 62.4 8.5 37.5 107.9 45.3 80.6 57.9 41.5 7.4 36.8 41.7 31.6 9.6 0.6 15.6 13.1 163.3 1.7 22.8 27.2 12.0 11.4 26.5 7.5 9.5 118.1 8.2 5.3 9.5 52.1 56.0 67.8 14.9 134.6 31.3 3.1 18.3 21.5 32.8 320.9 145.7 13.1 156.5 12.2 3.1 196.6 17.5 21.6 29.4 5.9 3.2 121.9 12.9 50.5 1.3 44.7 3.3 77.9 78.9 62.0 45.9 169.6 43.3 3.6 25.3 23.7 9.5 30.7 4.3 32.9 CTSH "ACC-4, ACC-5, ACC4, ACC5, CPSB" ENSG00000103811 "Cathepsin H" P09668 15 78921058-78949574 "Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lung: 349.6" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 1569.9;Proximal tubular cells: 523.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "classical monocyte: 208.5;intermediate monocyte: 137.7;memory B-cell: 83.3;myeloid DC: 183.6;naive B-cell: 56.0;non-classical monocyte: 94.8" "Group enriched" "Detected in all" 5 "B-cells: 83.3;dendritic cells: 183.6;monocytes: 208.5" "Cell line enhanced" "Detected in many" "CAPAN-2: 306.4;HaCaT: 228.2;HDLM-2: 183.0;OE19: 197.4;RT4: 362.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000458, HPA003524" Enhanced Supported "Vesicles,Cytosol,Cytoplasmic bodies" "Intracellular and membrane" NA NA 8700000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 11: Alveolar cells - Smell perception" "Vesicles, Cytosol, Cytoplasmic bodies" "CAB000458: , HPA003524: AB_1846075" "unprognostic (6.47e-2)" "unprognostic (4.65e-3)" "unprognostic (1.05e-1)" "prognostic favorable (6.90e-4)" "unprognostic (4.37e-2)" "unprognostic (1.93e-1)" "unprognostic (7.18e-2)" "unprognostic (3.30e-3)" "unprognostic (2.22e-1)" "unprognostic (5.96e-2)" "unprognostic (4.10e-2)" "unprognostic (3.89e-2)" "unprognostic (6.63e-3)" "unprognostic (3.83e-1)" "unprognostic (4.42e-2)" "unprognostic (2.70e-3)" "unprognostic (1.79e-3)" 34.3 36.4 29.4 100.6 30.2 36.9 48.8 29.9 47.1 112.8 31.4 32.5 77.8 46.7 26.8 37.9 57.6 104.6 51.3 29.6 32.9 238.2 89.5 349.6 191.8 30.8 31.4 30.0 75.5 77.6 10.1 25.7 31.5 59.7 27.3 4.7 63.0 70.7 16.3 48.4 56.7 43.1 30.7 51.8 93.9 10.1 32.7 51.8 27.7 37.7 131.3 202.2 30.6 32.4 122.0 10.0 1.2 30.5 5.4 0.5 20.3 8.6 3.0 13.9 7.0 17.6 306.4 34.6 12.6 0.0 13.5 228.2 5.2 52.6 10.1 183.0 0.4 3.0 1.3 38.4 12.1 0.4 7.1 5.6 10.7 0.2 0.0 59.4 1.0 5.9 76.0 0.0 17.9 2.8 32.6 87.8 8.9 197.4 4.9 0.3 0.4 5.9 49.9 362.1 2.6 5.2 41.5 27.8 75.4 10.1 12.5 48.0 16.4 0.2 6.2 0.0 5.3 0.8 92.4 19.5 0.1 89.2 12.3 0.0 208.5 2.0 7.6 137.7 29.7 83.3 20.5 7.4 183.6 56.0 1.8 3.8 8.7 3.2 94.8 22.9 18.3 147.5 29.4 30.2 29.9 47.1 29.6 32.9 30.8 31.4 31.5 30.7 32.7 32.4 169.8 237.2 1569.9 59.1 127.4 24.2 280.7 363.9 30.1 1.3 45.5 41.7 26.2 358.9 258.7 367.8 4.2 19.8 8.1 9.1 84.1 225.0 25.3 67.0 86.0 124.5 9.1 3.0 2.2 142.0 39.6 53.8 106.0 42.8 32.8 2.7 14.3 115.5 256.7 0.0 2.9 18.6 101.7 177.8 259.6 22.6 73.0 350.4 80.0 15.9 360.9 22.6 5.2 1.5 1.1 84.6 16.0 6.0 155.8 112.0 153.0 523.2 261.6 6.6 19.7 4.5 22.3 12.3 56.4 41.6 18.6 23.4 29.4 17.8 40.1 340.4 CTSK "CTSO, CTSO2, PKND, PYCD" ENSG00000143387 "Cathepsin K" P43235 1 150794880-150809577 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Thiol protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "cervix: 420.6" "Cell type enhanced" "Detected in many" "Fibroblasts: 372.4;Langerhans cells: 123.6;Leydig cells: 119.0;Melanocytes: 97.8;Peritubular cells: 149.7;Theca cells: 80.9" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in all" 6 "cerebral cortex: 18.1" "Immune cell enhanced" "Detected in some" "classical monocyte: 1.8" "Lineage enriched" "Detected in single" 4 "monocytes: 1.8" "Group enriched" "Detected in many" 9 "ASC diff: 2284.0;ASC TERT1: 813.2;BJ hTERT+: 1949.1" "Low region specificity" "Detected in all" HPA050346 Supported Vesicles "Intracellular and membrane" NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 46: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" Vesicles "HPA050346: AB_2681101" "unprognostic (1.48e-1)" "unprognostic (9.29e-2)" "unprognostic (1.21e-1)" "unprognostic (7.61e-3)" "unprognostic (5.08e-2)" "unprognostic (6.57e-2)" "unprognostic (1.02e-1)" "unprognostic (6.60e-2)" "unprognostic (2.11e-1)" "unprognostic (1.01e-1)" "unprognostic (1.49e-1)" "unprognostic (3.54e-2)" "prognostic unfavorable (7.12e-5)" "unprognostic (6.07e-3)" "unprognostic (2.98e-2)" "unprognostic (5.93e-3)" "unprognostic (6.41e-2)" 224.1 12.5 2.7 33.1 2.8 3.1 227.7 2.9 18.1 420.6 16.4 68.6 13.8 334.0 44.9 46.0 74.0 299.2 35.8 2.7 2.6 12.7 9.0 36.4 42.1 2.7 2.7 78.4 10.6 6.1 14.6 18.9 2.6 34.1 61.8 6.9 53.3 38.0 15.7 219.8 63.8 141.6 2.8 20.2 41.7 15.1 2.7 12.3 34.7 46.3 48.7 210.5 176.2 2.9 0.7 0.3 1.4 0.8 2284.0 813.2 1.0 55.2 1949.1 3.3 8.3 0.3 0.3 0.4 0.6 129.8 0.0 0.6 0.3 0.4 1.2 0.4 0.4 1.4 0.5 0.0 11.0 0.2 1.3 156.5 1.7 50.5 0.7 137.6 4.2 0.6 0.4 1.4 1.5 1.4 0.0 3.0 10.2 1.0 0.0 0.2 0.1 0.1 3.2 0.1 0.6 2.9 0.4 0.0 29.3 3.9 1.0 1.5 1.0 0.7 0.5 0.6 0.6 2.3 1.7 3.6 184.1 0.0 9.9 0.0 1.8 0.2 0.0 1.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.3 0.2 0.4 0.6 2.7 2.8 2.9 18.1 2.7 2.6 2.7 2.7 2.6 2.8 2.7 2.9 17.9 3.2 4.6 2.6 1.1 68.8 0.5 1.6 2.2 12.1 3.7 9.5 2.0 1.5 3.9 3.7 4.2 1.3 2.8 1.5 0.0 1.0 0.9 2.5 59.0 10.2 1.2 0.8 5.0 0.2 2.5 372.4 11.2 3.8 0.0 77.5 14.6 0.5 21.4 3.3 7.7 1.6 8.2 4.6 123.6 4.4 119.0 8.7 97.8 7.5 4.9 2.7 3.1 7.1 2.5 1.4 1.4 149.7 0.8 1.0 1.4 0.1 2.2 7.7 13.1 4.5 33.9 1.4 1.0 2.6 59.1 1.0 5.4 80.9 1.0 0.7 CTSL "CTSL1, FLJ31037" ENSG00000135047 "Cathepsin L" P07711 9 87724051-87731469 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "placenta: 563.6" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 1081.6;Extravillous trophoblasts: 1012.3;Hepatic stellate cells: 580.4;Hofbauer cells: 1105.7;Macrophages: 537.2;Syncytiotrophoblasts: 1543.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 10 "intermediate monocyte: 128.1;non-classical monocyte: 195.2" "Lineage enriched" "Detected in many" 12 "monocytes: 195.2" "Cell line enhanced" "Detected in many" "ASC TERT1: 2305.0;HSkMC: 1061.0" "Low region specificity" "Detected in all" "CAB000459, HPA070413" Enhanced Approved "Golgi apparatus,Vesicles" "Intracellular and membrane" NA NA 17000000 "Cluster 51: Monocytes - Innate immune response" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 4: Macrophages - Innate immune response" "Golgi apparatus, Vesicles" "CAB000459: AB_2292484, HPA070413: " "unprognostic (1.05e-1)" "unprognostic (1.01e-1)" "unprognostic (1.24e-2)" "unprognostic (1.53e-1)" "prognostic unfavorable (3.73e-4)" "unprognostic (1.19e-3)" "unprognostic (8.12e-3)" "prognostic unfavorable (5.15e-5)" "unprognostic (2.09e-1)" "unprognostic (3.15e-1)" "unprognostic (6.80e-2)" "unprognostic (3.21e-1)" "prognostic favorable (4.34e-4)" "unprognostic (5.64e-3)" "unprognostic (2.26e-2)" "unprognostic (1.72e-1)" "unprognostic (7.11e-3)" 232.4 86.6 49.2 136.0 55.4 84.8 110.0 52.9 67.5 69.5 67.9 110.3 39.7 108.1 81.6 33.3 108.4 85.0 112.5 47.0 52.3 207.3 333.5 154.9 101.1 54.4 54.0 96.4 61.9 151.1 69.5 563.6 57.5 68.2 58.8 32.3 77.6 91.7 71.9 39.8 57.1 125.2 52.4 124.4 71.4 80.1 112.2 33.0 76.1 79.8 49.4 209.8 48.0 59.6 88.1 423.0 32.6 55.3 514.0 2305.0 198.4 267.2 781.8 232.2 300.6 43.0 86.3 0.0 128.9 355.4 754.0 67.5 49.8 86.0 198.4 1.9 37.8 18.1 111.2 105.1 352.6 0.1 51.4 1061.0 138.9 373.7 134.9 186.6 194.9 0.0 162.5 0.7 326.6 115.6 0.5 9.9 67.7 128.6 77.5 21.6 21.5 0.6 158.6 39.0 42.8 50.6 62.1 133.5 312.3 177.9 14.5 97.9 296.9 190.8 104.7 750.6 125.9 18.5 84.1 0.9 692.6 0.2 67.9 0.3 13.5 0.6 0.3 128.1 0.0 0.0 6.6 0.1 7.9 0.1 16.7 1.3 0.5 0.2 195.2 0.3 1.7 10.1 49.2 55.4 52.9 67.5 47.0 52.3 54.4 54.0 57.5 52.4 112.2 59.6 86.1 41.7 52.9 15.3 11.2 37.7 82.1 58.0 15.4 43.8 12.2 33.4 96.8 87.2 46.4 75.4 18.8 1081.6 0.3 16.3 27.4 91.8 5.3 48.1 119.9 110.0 11.5 251.2 18.6 93.4 1012.3 261.7 10.2 27.6 29.7 63.6 580.4 122.6 1105.7 13.5 24.0 8.5 20.3 206.9 105.4 17.4 156.9 537.2 64.0 14.0 16.2 79.5 0.0 17.6 31.7 67.2 5.6 187.3 1.9 34.5 8.0 138.3 67.3 45.4 92.1 176.9 136.3 207.4 60.5 6.8 34.0 1543.6 10.8 30.8 11.7 44.8 CTSO CTSO1 ENSG00000256043 "Cathepsin O" P43234 4 155921580-155953912 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "ASC TERT1: 37.1;HSkMC: 44.6;Karpas-707: 85.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002041 Approved "Intracellular and membrane" NA NA 25000 "Cluster 44: Non-specific - Transcription" "Cluster 85: Liver - Metabolism" "Cluster 2: Karpas-707 - Immune response" "Cluster 50: Fibroblasts - ECM organization" "HPA002041: AB_1078408" "unprognostic (3.96e-3)" "unprognostic (1.62e-2)" "unprognostic (1.03e-1)" "unprognostic (1.33e-2)" "unprognostic (9.10e-3)" "unprognostic (2.55e-1)" "unprognostic (3.80e-3)" "unprognostic (2.07e-1)" "unprognostic (6.62e-2)" "unprognostic (1.33e-1)" "unprognostic (2.20e-1)" "unprognostic (1.05e-1)" "unprognostic (7.55e-2)" "unprognostic (4.87e-3)" "unprognostic (4.73e-2)" "unprognostic (1.11e-1)" "unprognostic (1.79e-1)" 19.1 31.5 8.0 17.8 8.0 5.0 31.9 6.2 11.8 36.7 7.9 19.6 32.8 37.2 36.1 16.7 36.9 40.7 20.2 7.8 7.6 34.5 98.8 36.8 24.5 7.1 7.5 28.0 19.9 24.5 9.6 41.2 6.9 29.8 23.2 5.2 22.1 32.2 6.7 10.0 34.0 30.7 7.0 39.7 15.5 9.4 7.4 14.1 34.5 17.8 17.9 28.0 15.4 7.6 0.8 0.6 4.1 3.7 17.3 37.1 0.2 1.6 18.3 3.3 5.7 0.4 14.4 0.2 1.2 6.8 1.2 0.1 0.2 0.1 2.6 1.6 0.1 0.4 0.5 0.2 18.1 1.4 0.2 44.6 3.5 2.2 1.8 25.6 3.5 0.7 0.3 85.8 11.7 0.7 1.1 0.4 0.7 0.6 0.7 4.8 0.5 1.0 16.8 7.5 0.5 4.3 2.4 9.3 2.3 2.0 4.2 2.6 3.0 13.3 0.7 0.4 2.3 8.3 0.2 0.2 24.4 0.3 18.6 5.3 0.9 0.6 1.2 0.7 3.0 1.2 1.4 0.8 0.4 1.5 1.6 2.0 0.7 3.0 0.9 1.0 3.3 1.4 8.0 8.0 6.2 11.8 7.8 7.6 7.1 7.5 6.9 7.0 7.4 7.6 29.3 38.5 20.8 15.0 19.9 10.5 13.1 11.3 12.0 10.4 20.1 13.0 5.0 44.3 14.3 25.8 2.1 20.5 19.6 15.6 13.7 24.6 0.4 20.9 34.6 28.2 6.7 8.6 1.7 20.7 7.7 51.5 8.6 27.3 8.8 25.0 43.2 58.1 16.3 5.0 1.7 7.9 8.2 29.2 23.7 1.5 30.4 21.4 30.2 7.5 26.5 17.0 22.6 36.7 5.4 12.7 6.3 25.2 7.0 17.5 21.1 10.7 14.5 1.9 19.7 34.0 24.6 0.3 2.1 5.9 9.1 10.5 14.5 14.3 6.6 9.5 CTSS ENSG00000163131 "Cathepsin S" P25774 1 150730079-150765957 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 137.0;lymphoid tissue: 164.8" "Cell type enhanced" "Detected in many" "Hofbauer cells: 698.6;Kupffer cells: 2230.8;Macrophages: 1316.2;monocytes: 2312.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "classical monocyte: 2483.4" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "CAPAN-2: 81.6;HMC-1: 187.5;U-698: 387.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000460, HPA002988" Supported Approved Vesicles "Intracellular and membrane" NA NA 23000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 64: Macrophages - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Vesicles "CAB000460: , HPA002988: AB_1078409" "unprognostic (7.81e-2)" "unprognostic (9.04e-2)" "unprognostic (3.23e-2)" "unprognostic (3.93e-2)" "unprognostic (1.52e-1)" "unprognostic (1.12e-2)" "unprognostic (1.11e-1)" "unprognostic (1.23e-1)" "unprognostic (1.59e-1)" "unprognostic (6.00e-3)" "unprognostic (1.46e-1)" "unprognostic (3.89e-1)" "unprognostic (6.24e-2)" "unprognostic (7.50e-2)" "unprognostic (4.14e-2)" "unprognostic (2.13e-1)" "unprognostic (2.47e-3)" 40.0 16.7 4.0 87.8 4.5 137.0 20.3 4.8 7.1 9.4 8.0 83.6 60.2 7.8 5.7 16.5 17.8 29.1 10.6 3.4 5.5 9.3 40.4 88.4 71.7 11.8 8.0 4.9 11.3 2.3 4.7 23.6 11.2 9.1 59.4 3.4 23.9 7.3 4.1 7.1 64.6 16.3 7.7 164.8 42.6 3.8 10.4 20.1 11.5 9.0 38.5 42.9 10.0 16.1 3.7 10.9 0.2 0.3 1.2 1.4 0.7 0.4 8.6 0.9 1.3 1.2 81.6 44.3 5.7 1.2 15.3 2.1 0.2 0.7 0.5 26.9 0.2 29.0 1.1 0.8 0.2 33.6 187.5 2.6 0.1 6.6 1.5 0.5 6.3 0.6 3.4 45.0 2.4 0.3 0.4 22.5 0.2 0.1 0.3 14.9 4.6 49.8 10.7 8.7 0.3 0.4 1.1 2.3 0.8 0.3 0.4 49.8 9.1 6.2 1.3 0.8 1.2 27.8 2.2 387.3 28.5 35.2 2.3 20.9 2483.4 218.0 41.3 1735.3 51.1 139.5 46.6 50.9 571.0 138.8 45.0 40.8 1022.2 41.8 1655.1 106.8 77.4 2577.6 4.0 4.5 4.8 7.1 3.4 5.5 11.8 8.0 11.2 7.7 10.4 16.1 37.6 109.0 158.7 1.6 255.3 17.0 31.3 72.0 4.6 2.3 21.0 8.9 5.3 74.4 143.4 42.3 12.5 3.7 198.0 549.2 0.0 183.6 6.6 126.9 8.6 44.1 42.4 22.5 10.3 177.0 5.7 34.4 71.9 39.0 106.8 9.5 60.3 30.6 698.6 0.0 9.5 205.7 73.2 2230.8 316.4 3.0 5.3 1316.2 56.9 27.2 2312.9 0.5 137.0 0.5 0.9 200.9 466.5 2.2 121.4 20.6 210.8 4.7 488.9 4.9 19.7 5.6 13.3 0.2 0.5 12.4 15.5 6.2 108.9 66.0 237.8 113.3 CTSV "CTSL2, CTSU" ENSG00000136943 "Cathepsin V" O60911 9 97029677-97156556 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 10 "lymphoid tissue: 643.6" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 63.7;Cytotrophoblasts: 122.3;Extravillous trophoblasts: 153.0;Granulosa cells: 54.2;Syncytiotrophoblasts: 67.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Immune cell enriched" "Detected in some" 4 "plasmacytoid DC: 15.1" "Lineage enriched" "Detected in many" 4 "dendritic cells: 15.1" "Group enriched" "Detected in many" 8 "BEWO: 592.6;SuSa: 739.0" "Low region specificity" "Detected in all" CAB017112 Uncertain Approved "Nucleoplasm,Nucleoli fibrillar center,Plasma membrane,Cytosol" "Intracellular and membrane" NA NA 370000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 63: T-cells - Adaptive immune response" "Cluster 28: BEWO - Transcription regulation" "Cluster 38: Extravillous trophoblasts - Unknown function" "Nucleoli fibrillar center, Cytosol" "Nucleoplasm, Plasma membrane" "CAB017112: " "unprognostic (2.40e-1)" "unprognostic (2.74e-2)" "unprognostic (1.50e-1)" "prognostic favorable (8.41e-4)" "unprognostic (7.29e-2)" "unprognostic (5.59e-2)" "prognostic unfavorable (2.83e-5)" "unprognostic (7.04e-3)" "unprognostic (6.06e-2)" "unprognostic (1.39e-2)" "prognostic unfavorable (2.87e-4)" "unprognostic (1.86e-2)" "unprognostic (1.78e-1)" "unprognostic (2.41e-2)" "unprognostic (1.33e-1)" "unprognostic (3.04e-3)" "prognostic unfavorable (2.39e-4)" 0.2 0.2 0.6 0.3 0.7 0.3 5.8 0.8 1.6 43.1 0.8 2.9 1.1 2.8 1.7 19.8 1.3 0.5 0.1 0.6 0.5 21.3 0.2 0.9 0.1 0.7 0.6 0.2 2.1 1.4 1.5 16.8 0.6 0.7 3.2 17.2 9.4 0.1 0.7 52.5 0.4 0.8 0.5 0.2 2.8 65.8 0.6 643.6 1.3 0.1 6.0 0.4 20.1 1.0 37.1 5.2 12.1 33.1 0.6 0.0 592.6 0.5 0.0 7.1 4.7 81.0 37.7 0.3 2.8 0.5 50.5 67.2 58.8 43.9 9.7 0.1 4.4 0.8 1.9 3.1 0.2 0.1 3.3 0.0 9.2 1.5 0.8 0.9 2.4 8.5 0.5 0.2 14.4 15.2 0.9 0.3 76.2 78.9 10.7 0.0 27.3 0.1 11.4 3.7 2.4 3.6 39.1 13.1 13.2 739.0 21.1 3.2 0.0 1.0 23.6 0.2 3.5 5.7 20.6 0.8 1.6 0.4 4.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.1 0.1 0.0 0.2 3.3 0.0 15.1 0.0 0.1 0.6 0.7 0.8 1.6 0.6 0.5 0.7 0.6 0.6 0.5 0.6 1.0 0.9 0.0 1.1 0.3 0.9 30.3 13.0 63.7 19.9 4.6 13.1 9.9 1.3 0.0 17.4 1.8 10.4 122.3 6.9 4.7 1.9 1.8 2.6 15.0 2.9 1.8 1.8 0.0 0.6 0.8 153.0 3.2 0.0 24.0 0.0 54.2 0.4 0.0 13.6 0.0 0.9 1.5 10.2 0.8 3.0 8.2 4.1 2.4 0.0 0.0 0.2 6.5 0.0 0.0 3.5 0.5 10.5 1.2 0.0 8.1 0.1 22.1 4.2 36.6 6.6 1.4 3.6 46.7 33.7 8.2 11.9 67.3 0.5 0.7 4.2 8.4 CTSW ENSG00000172543 "Cathepsin W" P56202 11 65879809-65883741 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 116.3;lymphoid tissue: 42.4" "Group enriched" "Detected in many" 9 "dendritic cells: 717.8;NK-cells: 867.2;T-cells: 352.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Group enriched" "Detected in all" 8 "gdT-cell: 1376.3;MAIT T-cell: 869.4;memory CD8 T-cell: 892.8;naive CD8 T-cell: 636.3;NK-cell: 2276.1" "Group enriched" "Detected in all" 39 "NK-cells: 2276.1;T-cells: 1376.3" "Group enriched" "Detected in some" 22 "HEL: 156.7;NB-4: 363.4" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "CAB016345, HPA066903" Enhanced "Intracellular and membrane" NA NA 270000 "Cluster 48: NK-cells - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 24: NB-4 - Immune response" "Cluster 63: NK-cells & T-cells - Immune response" "CAB016345: AB_626813, HPA066903: " "prognostic favorable (3.06e-4)" "unprognostic (2.06e-2)" "unprognostic (2.71e-2)" "prognostic favorable (8.36e-6)" "unprognostic (1.21e-1)" "prognostic favorable (9.89e-4)" "unprognostic (5.69e-2)" "unprognostic (1.09e-2)" "unprognostic (1.25e-3)" "unprognostic (5.14e-3)" "unprognostic (2.83e-2)" "unprognostic (1.59e-1)" "prognostic unfavorable (8.84e-6)" "unprognostic (3.86e-2)" "unprognostic (3.78e-1)" "unprognostic (1.26e-1)" "unprognostic (4.01e-3)" 5.1 2.9 0.8 12.9 0.9 116.3 3.7 1.8 1.6 2.6 0.6 5.6 6.1 6.7 2.8 3.1 4.0 6.2 2.9 0.8 0.9 2.1 6.5 24.0 29.5 1.6 0.7 2.4 1.8 0.5 1.1 3.3 1.2 2.1 6.3 0.0 9.1 3.9 1.3 2.7 6.1 2.7 1.2 42.4 8.3 1.2 1.1 7.8 3.2 0.4 13.9 8.6 2.5 1.1 0.1 0.0 0.1 0.0 0.4 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.2 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.4 0.1 0.0 156.7 0.3 0.0 0.0 11.8 0.4 0.0 0.0 0.0 0.1 0.0 0.0 5.0 0.0 9.1 0.2 0.2 1.9 363.4 0.1 0.0 0.1 0.1 0.0 0.3 0.0 0.1 0.0 0.2 0.1 0.0 1.1 0.0 0.0 5.6 0.1 0.0 0.1 0.4 0.1 0.3 0.5 0.0 0.2 9.9 0.3 46.4 3.4 4.8 1376.3 4.0 869.4 5.1 145.3 892.8 37.6 3.7 86.0 636.3 25.7 2276.1 5.4 23.3 23.7 809.3 0.8 0.9 1.8 1.6 0.8 0.9 1.6 0.7 1.2 1.2 1.1 1.1 5.1 0.0 4.2 0.0 9.7 4.6 0.4 0.0 1.8 0.0 2.3 2.2 0.4 2.8 1.4 0.0 0.0 0.4 717.8 0.3 0.0 0.3 2.0 0.9 0.9 1.9 0.0 44.1 0.0 0.0 0.2 4.0 12.8 1.1 71.7 0.1 5.7 1.6 1.9 0.0 0.0 0.2 0.0 5.6 34.1 11.1 0.0 9.9 17.8 0.0 6.1 0.0 867.2 0.0 0.2 0.0 0.0 0.0 57.7 0.3 0.0 1.1 0.8 0.0 0.0 1.6 1.9 0.3 1.2 0.8 6.3 0.3 352.6 0.1 0.3 0.3 CTSZ CTSX ENSG00000101160 "Cathepsin Z" Q9UBR2 20 58985686-59008238 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hofbauer cells: 1078.9;Langerhans cells: 983.5;Macrophages: 652.3;monocytes: 723.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 542.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025114, HPA049876, HPA053504" Supported Supported Vesicles "Intracellular and membrane" NA NA 88000000 "Cluster 49: Eosinophils - Unknown function" "Cluster 64: Macrophages - Immune response" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 41: Macrophages - Immune response" Vesicles "CAB025114: , HPA049876: AB_2680927, HPA053504: AB_2682172" "unprognostic (7.30e-2)" "unprognostic (3.98e-2)" "unprognostic (4.07e-2)" "unprognostic (1.11e-3)" "unprognostic (8.25e-3)" "unprognostic (1.15e-1)" "unprognostic (4.12e-2)" "unprognostic (6.59e-2)" "unprognostic (1.59e-1)" "unprognostic (1.22e-1)" "unprognostic (1.33e-1)" "unprognostic (5.33e-2)" "prognostic unfavorable (5.72e-5)" "unprognostic (1.96e-1)" "unprognostic (6.92e-2)" "unprognostic (1.19e-1)" "unprognostic (2.04e-1)" 178.1 117.8 18.9 208.8 21.8 99.8 137.0 20.5 32.0 92.1 59.6 173.8 215.4 87.3 13.4 53.1 88.9 89.4 152.6 15.3 33.9 125.6 356.4 233.3 271.5 31.6 23.5 71.0 89.4 91.8 112.5 118.7 27.9 87.8 77.1 4.1 181.0 66.3 58.7 58.5 226.0 97.9 26.2 234.4 88.2 24.6 47.2 57.1 122.3 54.6 91.3 146.3 69.0 45.4 205.4 139.8 1.1 1.1 114.2 124.2 106.5 291.0 225.4 187.4 152.3 231.6 324.6 96.5 213.9 542.1 0.5 160.1 51.4 257.5 30.2 362.1 13.6 80.3 169.0 0.8 137.3 9.0 331.0 130.9 127.8 83.1 62.4 34.8 281.3 1.1 74.0 48.7 90.0 1.1 1.3 70.6 11.5 43.5 158.2 2.9 0.4 135.7 86.3 25.5 2.7 1.7 222.4 258.4 0.8 19.5 131.9 148.4 420.5 1.4 161.8 209.0 2.0 253.7 172.0 18.2 2.8 207.9 0.4 1.2 1.5 1.6 0.6 1.4 0.4 1.1 0.6 0.4 1.1 1.4 0.7 0.8 1.6 0.5 2.9 1.8 0.3 0.7 18.9 21.8 20.5 32.0 15.3 33.9 31.6 23.5 27.9 26.2 47.2 45.4 132.1 16.0 5.3 5.9 119.8 50.3 64.5 33.8 24.5 6.7 67.4 99.6 21.7 62.9 14.1 71.7 0.0 38.2 104.8 303.6 23.5 176.0 3.5 52.9 47.7 82.2 27.1 63.3 5.3 42.4 104.8 71.5 19.4 71.3 10.8 68.4 62.8 363.0 1078.9 11.8 3.0 56.6 26.4 334.0 983.5 6.0 13.1 652.3 101.4 23.4 723.6 58.6 21.6 2.5 2.5 82.6 217.5 13.9 96.3 50.6 339.8 90.0 18.8 5.0 46.0 67.5 74.5 3.7 4.8 14.5 41.5 41.3 33.4 3.3 99.7 52.7 CYLD "CYLD1, KIAA0849, USPL2" ENSG00000083799 "CYLD lysine 63 deubiquitinase" Q9NQC7 16 50742050-50801935 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Immunity, Innate immunity, Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 94.3" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 136.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011713, HPA050095" Approved Supported "Nucleoplasm,Centriolar satellite" Yes No "Cluster 10: Basophils - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 44: HDLM-2 - Immune response" "Cluster 24: Non-specific - Transcription regulation" "Centriolar satellite" Nucleoplasm "CAB011713: AB_731794, HPA050095: AB_2681013" "unprognostic (9.83e-2)" "unprognostic (1.17e-2)" "unprognostic (5.01e-2)" "unprognostic (2.83e-2)" "unprognostic (3.84e-1)" "unprognostic (5.06e-2)" "unprognostic (3.87e-2)" "unprognostic (3.24e-2)" "unprognostic (9.46e-2)" "unprognostic (1.11e-1)" "unprognostic (1.18e-2)" "unprognostic (2.32e-1)" "unprognostic (1.03e-1)" "unprognostic (1.07e-1)" "unprognostic (3.43e-2)" "unprognostic (6.83e-2)" "unprognostic (8.42e-2)" 14.3 22.0 23.9 38.8 23.5 94.3 13.6 17.9 18.2 13.0 22.3 16.3 16.1 15.1 12.1 23.3 11.0 20.5 20.1 17.3 23.3 14.2 21.0 21.5 53.4 21.3 27.8 15.4 15.2 23.0 15.4 15.4 23.6 16.3 19.3 22.0 18.9 16.0 34.3 15.2 16.2 16.8 21.6 39.0 19.9 38.3 32.7 35.6 24.9 20.5 48.4 24.1 12.9 24.2 26.9 8.3 9.4 10.6 14.3 21.0 8.7 39.1 56.7 39.9 23.4 6.9 12.5 30.7 13.7 38.3 43.4 10.3 11.3 23.7 58.7 136.6 16.6 15.5 15.3 5.8 29.1 15.4 69.5 23.0 18.6 48.1 50.1 37.7 16.3 21.3 6.6 26.1 56.4 4.0 14.4 22.3 10.1 8.5 13.3 13.4 18.8 29.4 12.9 9.1 12.0 9.2 33.1 11.2 9.8 14.3 11.0 18.9 18.6 67.2 15.4 23.4 15.9 68.0 68.4 33.2 49.3 16.7 14.7 64.6 15.2 38.3 18.1 17.7 21.8 17.2 27.1 24.5 18.3 11.1 24.4 19.4 32.3 25.7 18.8 11.0 37.3 19.5 23.9 23.5 17.9 18.2 17.3 23.3 21.3 27.8 23.6 21.6 32.7 24.2 28.8 44.8 31.8 31.6 87.7 120.1 59.5 32.2 40.9 89.2 35.5 26.0 34.4 21.5 32.9 18.4 93.8 6.8 84.1 28.3 5.9 20.0 48.2 22.5 24.9 36.0 31.1 26.1 51.9 19.1 4.4 37.3 22.4 47.1 80.5 21.4 27.8 25.5 21.5 67.3 54.7 10.7 30.5 40.0 127.6 31.3 25.4 66.4 74.7 57.1 63.7 23.3 70.0 51.8 119.2 18.0 22.4 21.1 79.7 66.4 15.4 13.9 23.3 48.3 6.6 54.2 30.5 59.2 15.2 64.3 155.6 4.1 119.5 21.3 14.8 66.7 GATD1 "FLJ34283, PDDC1" ENSG00000177225 "Glutamine amidotransferase like class 1 domain containing 1" Q8NB37 11 767220-777488 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 44.8;Alveolar cells type 2: 22.1;Collecting duct cells: 22.0;Theca cells: 25.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HEK 293: 120.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008812 Uncertain Supported Nucleoplasm "Secreted to blood" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 35: Non-specific - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "HPA008812: AB_10962724" "unprognostic (3.39e-1)" "unprognostic (2.48e-2)" "unprognostic (1.31e-1)" "unprognostic (3.58e-2)" "unprognostic (2.82e-2)" "unprognostic (3.03e-2)" "prognostic unfavorable (3.98e-4)" "unprognostic (3.50e-2)" "unprognostic (2.19e-1)" "unprognostic (5.67e-2)" "unprognostic (5.23e-3)" "unprognostic (4.89e-3)" "prognostic favorable (3.79e-5)" "unprognostic (2.84e-2)" "unprognostic (8.40e-2)" "unprognostic (6.11e-2)" "unprognostic (6.61e-3)" 15.9 37.5 37.7 11.3 35.8 7.9 16.7 35.1 37.8 22.7 36.6 23.3 15.4 24.9 12.6 23.7 22.7 7.3 16.3 37.4 36.5 24.0 19.3 15.4 11.2 46.4 41.8 25.9 15.9 10.5 30.1 9.2 35.8 23.0 6.5 9.7 17.5 12.2 14.4 21.0 18.2 7.9 38.4 19.6 17.8 18.6 45.3 8.8 22.0 6.5 6.8 19.7 20.4 37.5 41.3 22.3 22.2 23.9 10.2 15.6 20.9 24.2 10.5 22.0 19.3 15.8 62.5 22.1 8.6 16.0 23.2 42.7 16.7 21.6 11.0 28.1 120.5 13.0 38.8 36.0 17.5 25.4 27.8 22.4 23.2 9.3 14.2 19.9 17.1 25.8 34.2 20.0 12.4 11.0 29.3 27.5 21.3 13.4 42.8 31.4 15.1 28.0 19.2 9.1 56.9 22.3 22.9 32.0 16.6 5.7 28.5 16.8 31.3 23.2 17.5 12.7 18.8 23.4 12.9 28.4 35.4 33.9 19.6 1.0 5.2 0.9 2.9 6.6 2.1 2.7 3.0 2.9 6.9 2.3 2.4 1.7 0.5 1.2 2.6 4.0 1.4 2.0 37.7 35.8 35.1 37.8 37.4 36.5 46.4 41.8 35.8 38.4 45.3 37.5 8.7 44.8 22.1 0.0 4.4 0.0 0.0 0.0 0.0 0.0 11.9 10.4 0.0 0.0 7.4 22.0 0.0 13.8 5.2 0.0 5.9 10.3 0.0 11.8 15.2 3.8 0.0 0.0 0.0 7.6 7.9 8.5 0.0 9.6 6.3 19.2 0.0 0.0 13.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.2 0.0 0.0 4.6 0.0 0.0 0.0 0.0 16.6 0.0 0.0 1.3 0.0 0.0 14.7 7.3 0.0 0.0 0.0 5.8 0.0 0.0 0.0 0.0 9.6 3.9 25.8 0.0 0.0 GGH ENSG00000137563 "Gamma-glutamyl hydrolase" Q92820 8 63014881-63039407 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "kidney: 125.7;liver: 188.6" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 510.3;Early spermatids: 471.0;Extravillous trophoblasts: 273.4;Proximal tubular cells: 340.8;Syncytiotrophoblasts: 754.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "plasmacytoid DC: 30.6" "Lineage enriched" "Detected in all" 5 "dendritic cells: 30.6" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB019296, HPA025226" Approved "Intracellular and membrane" NA NA 1200000000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 2: Karpas-707 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "CAB019296: , HPA025226: AB_1849645" "unprognostic (9.29e-2)" "unprognostic (1.22e-1)" "unprognostic (5.48e-3)" "prognostic unfavorable (3.99e-7)" "unprognostic (5.57e-2)" "unprognostic (1.08e-1)" "unprognostic (1.14e-1)" "prognostic unfavorable (1.65e-4)" "unprognostic (1.95e-2)" "unprognostic (1.60e-1)" "unprognostic (2.11e-2)" "unprognostic (1.32e-1)" "unprognostic (1.69e-2)" "unprognostic (9.62e-3)" "unprognostic (1.50e-1)" "unprognostic (2.36e-1)" "unprognostic (6.50e-2)" 9.8 5.4 11.1 14.2 11.1 43.7 16.5 10.7 14.3 5.9 13.1 54.3 11.3 6.3 4.4 20.7 3.5 4.3 3.1 11.1 12.3 125.7 188.6 8.0 10.9 13.3 11.1 3.1 9.9 13.1 1.9 54.9 13.7 4.4 74.4 2.1 13.0 3.7 2.1 27.2 9.9 11.6 10.1 5.5 8.2 33.9 14.4 17.8 2.4 3.2 22.5 8.5 10.8 11.1 110.5 97.6 97.4 15.7 94.1 39.6 69.6 64.3 105.1 94.2 137.7 144.5 183.8 69.8 18.0 77.1 166.8 87.2 97.2 101.9 138.9 139.0 71.6 112.3 50.3 105.1 17.6 53.5 65.9 29.1 29.2 93.9 50.7 59.4 116.1 66.9 62.4 255.2 177.3 64.3 28.8 71.1 51.0 231.6 86.0 77.6 95.2 98.1 75.8 40.3 38.6 69.9 91.8 103.6 98.5 91.6 116.6 65.8 65.5 104.2 115.6 99.4 111.3 112.6 127.2 88.3 158.0 0.1 185.0 0.0 2.1 2.3 1.1 1.7 0.8 6.5 1.5 1.7 0.9 2.7 1.8 1.9 3.0 4.4 2.0 30.6 2.7 1.9 11.1 11.1 10.7 14.3 11.1 12.3 13.3 11.1 13.7 10.1 14.4 11.1 13.1 16.0 7.3 11.1 26.1 30.2 23.2 66.6 9.1 2.0 14.9 21.0 3.2 17.2 31.1 22.0 0.0 510.3 11.7 49.2 37.2 19.7 471.0 5.4 11.5 13.1 13.2 62.5 11.5 7.4 273.4 27.2 11.7 7.6 10.8 21.4 13.6 219.5 72.4 0.0 8.7 70.7 44.7 21.0 15.5 154.2 5.9 12.0 24.9 1.0 32.1 23.1 2.1 3.5 2.9 4.3 23.7 8.2 106.9 10.5 4.3 340.8 18.3 1.3 26.3 12.8 20.4 80.3 133.0 35.9 43.0 754.5 8.5 9.3 102.0 23.1 LGMN "LGMN1, PRSC1" ENSG00000100600 Legumain Q99538 14 92703807-92748679 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hofbauer cells: 1448.9;Macrophages: 346.1;Syncytiotrophoblasts: 416.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 11 "plasmacytoid DC: 209.2" "Lineage enriched" "Detected in all" 12 "dendritic cells: 209.2" "Cell line enhanced" "Detected in many" "RPMI-8226: 898.6;U-266/70: 462.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001426 Enhanced Approved Nucleoplasm,Vesicles "Intracellular and membrane" NA NA 2000000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 1: Thyroid gland - Transcription" "Cluster 25: RPMI-8226 - Immune response" "Cluster 4: Macrophages - Innate immune response" Vesicles Nucleoplasm "HPA001426: AB_1079247" "unprognostic (1.19e-1)" "unprognostic (1.16e-1)" "unprognostic (2.37e-1)" "unprognostic (1.52e-1)" "unprognostic (1.99e-1)" "unprognostic (3.29e-2)" "unprognostic (4.52e-2)" "unprognostic (1.31e-1)" "unprognostic (5.03e-2)" "unprognostic (3.50e-2)" "unprognostic (4.70e-2)" "unprognostic (2.47e-1)" "prognostic favorable (4.70e-4)" "unprognostic (8.06e-2)" "unprognostic (3.64e-2)" "unprognostic (7.18e-3)" "unprognostic (7.24e-2)" 173.7 44.4 37.6 82.2 38.6 20.6 69.7 31.7 60.8 52.6 51.2 102.5 110.4 30.8 36.8 64.5 36.6 145.8 85.3 40.0 40.3 205.9 111.1 107.3 177.0 35.6 37.3 33.0 37.9 247.0 24.9 262.1 42.4 51.9 105.9 19.7 56.4 32.2 50.4 32.7 97.6 65.0 35.9 202.2 107.0 29.8 62.8 52.8 93.2 50.4 54.9 144.7 52.1 49.4 33.2 47.5 30.8 57.4 94.3 76.0 108.4 70.3 67.0 71.7 84.2 36.9 58.6 18.2 101.5 116.5 44.3 81.5 0.0 60.8 33.7 1.6 36.2 1.2 24.4 42.8 27.7 1.0 2.7 54.2 29.1 68.4 39.4 21.3 82.1 33.7 7.4 150.9 5.2 45.2 8.9 1.2 15.1 208.2 32.1 8.4 27.1 898.6 59.2 129.1 33.6 23.2 97.9 59.4 53.0 66.8 43.9 0.6 47.2 35.3 44.8 64.5 21.8 462.5 58.0 25.0 20.0 0.2 69.1 1.9 1.6 0.1 0.8 3.1 1.6 17.0 5.1 1.3 19.3 14.5 15.2 9.0 1.6 3.7 1.0 209.2 9.7 7.0 37.6 38.6 31.7 60.8 40.0 40.3 35.6 37.3 42.4 35.9 62.8 49.4 34.9 57.7 128.0 8.8 33.9 23.1 37.5 36.0 22.2 10.6 31.2 37.6 29.8 42.9 48.1 31.3 93.8 181.8 24.5 64.2 9.8 61.3 1.3 79.4 23.5 38.3 36.5 22.7 19.2 50.6 140.2 63.8 73.4 177.7 8.8 17.6 276.3 46.4 1448.9 13.5 41.0 31.1 95.6 317.6 89.0 3.3 30.4 346.1 48.0 27.2 37.5 23.6 2.1 10.6 15.2 50.5 57.1 57.9 24.7 44.6 163.4 220.4 20.9 19.8 19.7 40.4 62.1 19.9 17.6 22.3 17.5 416.3 8.2 15.1 48.3 44.7 MALT1 "MLT, PCASP1" ENSG00000172175 "MALT1 paracaspase" Q9UDY8 18 58671465-58754477 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Immunity, Ubl conjugation pathway" "Hydrolase, Protease" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "RPTEC TERT1: 88.9" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB004494, HPA048432" Enhanced Approved "Nucleoli fibrillar center,Cytosol" No No "Cluster 21: B-cells - Adaptive immune response" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 65: Plasmacytoid DCs - Unknown function" "Nucleoli fibrillar center" Cytosol "CAB004494: AB_627909, HPA048432: AB_2680389" "unprognostic (3.25e-1)" "unprognostic (2.31e-1)" "unprognostic (3.64e-2)" "unprognostic (3.25e-2)" "unprognostic (1.65e-3)" "unprognostic (4.67e-2)" "unprognostic (6.46e-2)" "unprognostic (4.50e-2)" "unprognostic (3.33e-2)" "unprognostic (4.16e-3)" "unprognostic (3.74e-1)" "unprognostic (2.07e-1)" "unprognostic (2.53e-2)" "unprognostic (2.34e-1)" "unprognostic (2.97e-1)" "unprognostic (1.03e-1)" "unprognostic (6.00e-2)" 7.1 2.5 2.9 11.2 2.8 10.5 6.3 4.8 3.6 7.7 4.2 5.1 3.6 5.4 4.2 12.5 5.1 5.8 5.4 3.1 4.1 6.7 6.9 7.3 21.1 3.2 2.6 5.3 4.0 5.3 4.7 4.0 3.0 11.5 5.5 8.7 5.8 3.8 8.3 9.4 7.7 4.2 3.0 11.5 4.6 8.2 4.1 15.6 5.3 2.8 23.1 7.1 9.6 3.6 11.4 16.0 16.8 5.2 3.1 6.7 9.2 19.7 12.1 15.7 12.6 13.8 13.5 27.0 10.3 24.0 11.1 12.0 10.8 7.6 20.8 17.0 6.8 9.7 9.0 21.8 4.0 20.1 11.4 4.0 12.2 11.8 10.4 6.6 3.4 7.7 15.3 42.3 9.6 3.3 4.7 9.7 6.3 4.1 7.1 14.8 11.5 19.7 88.9 2.8 2.5 4.5 11.7 6.0 9.3 12.0 5.1 12.2 5.7 22.6 9.1 7.1 20.8 38.5 54.4 16.3 10.6 15.6 9.9 0.3 0.5 0.2 0.7 0.7 0.6 1.1 1.4 0.8 0.7 2.1 1.0 0.8 0.3 0.5 0.5 1.3 0.8 0.4 2.9 2.8 4.8 3.6 3.1 4.1 3.2 2.6 3.0 3.0 4.1 3.6 35.0 22.4 19.2 24.2 67.8 33.0 32.3 4.8 26.2 14.7 13.6 11.0 14.4 10.0 7.0 11.0 85.5 6.2 53.2 11.1 3.9 16.6 12.7 10.4 17.5 31.1 6.7 0.8 61.3 8.5 6.0 15.7 13.7 24.7 31.7 28.1 10.4 11.1 11.8 55.5 42.9 8.6 8.2 21.0 96.5 8.0 10.2 55.9 12.4 34.7 79.5 26.2 20.6 52.3 11.9 16.2 21.9 7.2 42.2 46.6 8.0 30.7 5.8 18.1 19.7 16.1 12.9 40.1 35.6 25.4 24.7 9.0 55.2 5.7 10.7 38.1 OTUB1 "FLJ20113, FLJ40710" ENSG00000167770 "OTU deubiquitinase, ubiquitin aldehyde binding 1" Q96FW1 11 63985853-64001811 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Adaptive immunity, DNA damage, DNA repair, Immunity, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039176, CAB072836" Approved Supported Approved Nucleoplasm,Cytosol NA NA 500000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 27: Brain & Skin - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Cytosol" "CAB072836: , HPA039176: AB_10674980" "unprognostic (2.50e-1)" "unprognostic (5.70e-3)" "unprognostic (3.93e-2)" "unprognostic (1.63e-1)" "unprognostic (2.78e-1)" "prognostic unfavorable (3.05e-4)" "unprognostic (1.85e-3)" "unprognostic (1.34e-2)" "unprognostic (2.45e-1)" "unprognostic (1.27e-2)" "unprognostic (3.04e-1)" "unprognostic (1.34e-1)" "unprognostic (1.33e-3)" "unprognostic (6.76e-2)" "unprognostic (1.42e-1)" "unprognostic (4.84e-2)" "unprognostic (1.82e-1)" 44.8 57.0 69.9 43.0 78.0 63.5 47.3 53.0 93.4 54.1 39.7 51.9 42.0 49.0 37.4 85.4 55.8 35.9 62.4 79.3 62.5 61.3 47.0 47.1 59.8 65.0 58.0 44.5 43.9 47.1 48.6 49.3 66.1 53.5 39.3 25.6 54.3 42.6 70.2 78.1 51.9 38.0 51.2 58.6 54.0 57.1 65.0 56.0 51.9 48.4 57.1 52.5 56.7 67.7 113.4 198.9 107.2 95.7 70.7 77.8 83.0 66.0 97.1 143.6 105.1 138.1 104.5 59.3 122.0 106.6 124.4 138.1 140.4 165.4 88.1 69.9 111.7 99.3 114.1 172.9 98.8 99.2 104.3 83.4 106.4 110.2 69.8 74.4 137.2 54.6 71.2 65.3 97.9 237.2 109.2 133.0 126.5 95.4 94.1 88.3 41.8 102.5 151.1 162.1 81.5 117.5 74.6 114.1 123.3 72.9 178.2 86.3 100.1 75.8 74.2 103.3 88.4 76.2 51.7 86.4 98.4 64.0 74.5 228.8 186.8 189.9 165.5 244.2 131.2 149.6 152.1 153.6 203.1 139.3 117.1 130.4 184.6 161.8 218.9 140.7 224.7 313.4 69.9 78.0 53.0 93.4 79.3 62.5 65.0 58.0 66.1 51.2 65.0 67.7 37.0 19.2 56.5 15.0 67.2 48.3 70.9 137.8 83.6 44.4 42.5 48.8 31.9 37.1 82.5 46.0 39.6 146.2 56.5 104.7 74.3 80.7 72.6 55.4 36.2 43.4 87.8 35.5 17.8 85.5 109.2 50.0 71.9 44.3 48.7 54.6 35.7 33.2 90.4 30.3 16.9 70.8 101.7 57.4 65.9 87.1 34.2 61.0 51.6 8.4 98.0 43.2 78.2 12.5 18.8 90.1 92.0 25.6 80.8 51.8 90.8 85.2 89.2 55.7 26.3 28.1 62.0 48.0 71.4 77.7 52.6 194.8 73.7 51.7 62.7 71.6 OTUB2 "C14orf137, FLJ21916, MGC3102" ENSG00000089723 "OTU deubiquitinase, ubiquitin aldehyde binding 2" Q96DC9 14 94026340-94048930 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "skin 1: 7.3;testis: 14.4" "Group enriched" "Detected in many" 8 "Early spermatids: 641.1;Late spermatids: 1415.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "GAMG: 16.5;Karpas-707: 18.0;OE19: 18.1;RPTEC TERT1: 11.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA002329, HPA075090" Enhanced NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 27: Brain & Skin - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 34: Spermatids - Unknown function" "HPA002329: AB_1079537, HPA075090: AB_2686734" "unprognostic (6.80e-3)" "unprognostic (1.39e-3)" "unprognostic (3.68e-3)" "unprognostic (4.82e-3)" "unprognostic (1.66e-1)" "unprognostic (2.20e-1)" "unprognostic (2.30e-3)" "unprognostic (1.18e-2)" "unprognostic (2.55e-1)" "unprognostic (3.09e-3)" "unprognostic (2.80e-2)" "unprognostic (1.16e-2)" "unprognostic (6.25e-3)" "unprognostic (1.15e-1)" "unprognostic (2.06e-2)" "unprognostic (1.02e-4)" "unprognostic (3.16e-1)" 0.3 0.6 1.2 0.2 1.1 0.2 0.8 1.3 1.3 1.3 0.1 0.5 0.3 0.8 0.3 3.8 0.6 0.4 0.1 1.0 0.8 0.6 0.8 0.4 0.3 0.1 1.3 0.7 0.7 1.9 0.2 1.8 0.1 0.6 0.8 0.6 0.7 0.2 0.1 7.3 0.3 0.3 0.1 0.2 0.5 14.4 2.5 0.1 0.2 0.0 0.8 0.9 1.5 0.5 1.3 3.7 2.4 2.3 0.9 0.7 2.6 0.5 0.3 1.4 2.1 0.8 5.9 0.3 2.2 0.6 16.5 0.3 3.2 1.7 1.1 0.9 1.5 0.1 0.4 3.9 1.3 0.0 0.6 0.6 2.1 0.5 0.9 1.8 1.6 3.3 0.1 18.0 0.7 1.3 0.1 0.4 0.7 18.1 3.1 0.1 0.2 1.0 11.2 1.7 1.8 1.3 0.7 0.8 1.9 1.6 6.3 0.8 1.7 0.9 2.8 0.7 1.0 3.0 2.2 0.0 1.7 0.9 1.4 0.0 0.6 0.0 0.0 0.8 0.0 0.0 0.1 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.2 1.2 1.1 1.3 1.3 1.0 0.8 0.1 1.3 0.1 0.1 2.5 0.5 0.5 0.0 0.5 0.7 0.2 0.1 0.7 4.0 0.6 1.5 1.1 1.1 0.5 0.0 2.4 0.0 0.0 4.2 0.1 1.9 1.9 4.3 641.1 6.4 2.8 0.9 0.0 2.7 1.9 1.6 1.5 0.6 4.6 24.8 0.0 2.2 0.4 0.9 1.4 0.0 1.3 1.4 2.0 1.2 1.3 1415.3 6.8 2.4 0.0 0.0 0.4 0.5 0.0 0.5 0.6 5.2 1.3 3.4 0.1 0.3 0.5 1.5 1.8 1.4 6.6 0.6 0.6 9.2 4.3 2.0 2.3 117.5 1.0 2.2 1.0 2.4 OTUD5 "DKFZp761A052, DUBA" ENSG00000068308 "OTU deubiquitinase 5" Q96G74 X 48922024-48958386 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Group enriched" "Detected in all" 10 "U-266/70: 1503.3;U-266/84: 407.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017375 Approved Approved "Nucleoplasm,Nucleoli fibrillar center,Cytosol" NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 29: U-266 - Adaptive immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Cytosol "Nucleoplasm, Nucleoli fibrillar center" "HPA017375: AB_1854844" "unprognostic (9.73e-2)" "prognostic favorable (9.57e-4)" "unprognostic (2.67e-2)" "unprognostic (7.25e-2)" "unprognostic (1.08e-1)" "unprognostic (6.65e-2)" "unprognostic (2.33e-3)" "prognostic favorable (1.48e-4)" "unprognostic (1.11e-1)" "unprognostic (1.14e-1)" "prognostic favorable (8.20e-4)" "unprognostic (1.32e-1)" "unprognostic (3.60e-1)" "unprognostic (1.19e-1)" "unprognostic (1.10e-1)" "unprognostic (4.88e-2)" "unprognostic (5.05e-3)" 37.7 44.8 42.9 36.9 44.9 56.7 36.6 39.2 45.5 40.6 33.6 45.8 39.6 43.0 29.9 37.5 41.4 24.7 29.9 44.8 46.1 41.1 39.5 39.6 43.4 44.2 42.8 46.8 37.7 35.6 46.1 26.4 46.0 43.1 21.7 30.2 36.3 32.0 39.7 44.6 47.3 27.0 38.3 60.7 37.5 24.2 44.9 47.0 42.3 25.2 35.8 39.9 36.7 43.9 53.0 77.8 36.0 88.9 59.2 52.3 41.4 45.7 52.9 55.9 59.8 39.7 57.3 58.9 29.2 56.8 49.1 63.3 54.2 45.7 51.7 69.1 65.0 44.5 79.4 45.0 49.3 43.4 48.7 58.1 41.2 58.2 39.5 61.4 44.7 47.8 56.9 90.7 40.0 52.3 67.7 89.2 64.9 19.5 60.4 53.0 52.5 77.4 38.9 46.4 34.7 60.7 60.2 38.7 61.7 82.7 51.6 39.2 64.2 36.5 46.2 97.2 38.1 1503.3 407.1 56.5 56.3 58.9 25.7 5.5 3.3 7.6 6.6 5.2 5.6 8.6 5.1 5.7 4.8 5.3 4.8 7.1 8.5 20.3 5.1 6.2 7.3 3.6 42.9 44.9 39.2 45.5 44.8 46.1 44.2 42.8 46.0 38.3 44.9 43.9 21.3 9.6 22.3 17.3 33.3 22.2 21.2 13.7 13.1 35.5 23.7 19.7 11.5 15.7 16.3 27.6 27.1 13.3 38.2 28.4 9.8 13.6 1.9 24.5 23.2 19.6 48.2 32.6 15.5 18.3 16.3 18.4 21.4 33.1 7.0 28.5 22.1 24.3 16.7 28.6 15.7 28.5 10.2 22.9 33.9 2.9 20.8 25.7 26.6 15.9 22.6 18.0 30.9 14.1 14.1 21.5 19.0 23.7 38.1 27.5 28.1 21.7 21.6 27.9 13.1 19.9 20.1 10.4 12.6 15.9 25.6 30.8 33.3 28.6 20.1 27.4 OTUD7A "C15orf16, CEZANNE2, OTUD7" ENSG00000169918 "OTU deubiquitinase 7A" Q8TE49 15 31475398-31870789 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "brain: 20.5" "Cell type enhanced" "Detected in many" "Astrocytes: 135.2;Excitatory neurons: 303.6;Inhibitory neurons: 219.7;Oligodendrocyte precursor cells: 100.0;Oligodendrocytes: 506.1" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AN3-CA: 1.7;HAP1: 1.0;SCLC-21H: 3.6;SH-SY5Y: 1.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044554 Approved Nucleoli,Cytosol NA NA "Cluster 70: Brain - Nervous system development" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Nucleoli, Cytosol" "HPA044554: AB_10794895" "unprognostic (3.61e-2)" "unprognostic (1.35e-3)" "unprognostic (1.39e-1)" "unprognostic (1.25e-3)" "unprognostic (1.29e-1)" "unprognostic (1.03e-4)" "unprognostic (1.50e-1)" "unprognostic (1.21e-1)" "unprognostic (1.38e-1)" "unprognostic (1.67e-1)" "unprognostic (3.24e-3)" "unprognostic (1.34e-1)" "unprognostic (1.79e-11)" "unprognostic (6.78e-2)" "unprognostic (2.76e-1)" "unprognostic (8.27e-2)" "unprognostic (1.79e-1)" 1.2 0.5 6.6 0.4 9.5 0.0 1.0 7.6 8.6 1.3 0.0 1.4 0.3 1.3 0.5 0.7 1.1 0.3 1.3 6.9 5.9 0.9 0.4 0.8 0.4 8.5 6.9 0.9 1.4 1.2 1.5 0.0 8.2 0.6 0.4 1.6 0.7 0.4 1.1 2.6 0.9 0.6 5.6 0.6 0.8 4.1 8.3 0.3 1.0 0.2 0.4 0.8 0.8 20.5 0.0 0.0 0.1 1.7 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.0 0.0 0.0 0.4 0.8 0.0 0.2 0.1 0.0 0.0 0.7 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.5 0.0 0.0 0.3 0.5 0.0 0.0 0.1 3.6 1.8 0.5 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 6.6 9.5 7.6 8.6 6.9 5.9 8.5 6.9 8.2 5.6 8.3 20.5 3.5 3.2 0.0 135.2 0.1 0.4 0.7 0.0 1.8 25.7 1.1 1.3 3.2 0.0 0.6 1.8 2.1 0.0 4.3 1.3 0.0 0.5 1.4 0.4 1.2 1.3 3.6 0.0 303.6 1.0 0.1 1.8 0.5 0.4 0.0 1.0 1.4 0.8 0.2 25.2 219.7 1.7 0.0 0.0 0.3 2.0 0.9 0.3 1.8 28.1 0.2 3.9 13.4 100.0 506.1 0.3 0.7 2.6 2.6 1.9 0.4 1.7 0.0 3.1 0.0 4.1 1.5 4.6 8.3 1.8 0.4 0.1 3.1 0.9 1.5 1.0 OTUD7B "CEZANNE, ZA20D1" ENSG00000264522 "OTU deubiquitinase 7B" Q6GQQ9 1 149937812-150010726 "Enzymes, Predicted intracellular proteins" "Adaptive immunity, Immunity, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 43.0" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 106.3;Oligodendrocytes: 176.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "basophil: 2.0" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027045, HPA076357" Supported Uncertain "Microtubules,Cytokinetic bridge,Mitotic spindle" Yes NA "Cluster 41: Basophils - Cellular respiration" "Cluster 70: Brain - Nervous system development" "Cluster 2: Karpas-707 - Immune response" "Cluster 9: Photoreceptor cells - Phototransduction" Microtubules "Cytokinetic bridge, Mitotic spindle" "HPA027045: AB_1854847, HPA076357: " "unprognostic (2.17e-2)" "unprognostic (2.93e-2)" "unprognostic (1.90e-1)" "prognostic favorable (7.47e-4)" "unprognostic (1.51e-1)" "unprognostic (1.05e-1)" "unprognostic (1.23e-3)" "unprognostic (1.46e-2)" "prognostic favorable (5.09e-5)" "unprognostic (4.90e-2)" "unprognostic (7.72e-2)" "unprognostic (8.94e-2)" "unprognostic (3.37e-2)" "unprognostic (1.67e-2)" "unprognostic (1.18e-1)" "unprognostic (4.52e-2)" "unprognostic (1.58e-2)" 11.7 7.7 21.0 3.8 39.2 1.1 7.8 28.7 18.5 9.9 6.8 7.6 6.2 10.5 3.8 7.7 9.3 4.8 7.1 15.3 22.1 5.6 10.7 7.3 1.9 41.4 37.2 10.9 6.1 10.9 3.4 7.1 35.5 6.6 7.1 10.1 7.8 7.5 18.6 5.8 6.2 10.8 27.9 3.6 6.7 12.7 31.7 2.1 6.7 16.2 3.2 6.3 5.2 43.0 17.2 13.5 9.3 15.6 12.0 11.1 8.8 11.8 17.3 14.0 9.6 10.0 13.6 0.2 7.5 21.7 6.3 13.4 13.2 13.1 14.6 16.5 6.7 6.6 18.9 6.8 12.8 7.6 6.9 12.4 9.9 23.7 20.6 10.9 11.5 2.0 18.4 18.1 10.1 17.5 1.3 2.1 11.9 12.8 13.1 1.8 12.9 4.4 5.4 23.2 6.0 11.4 20.8 15.2 18.5 12.1 12.6 4.0 13.9 14.4 13.2 9.8 14.0 19.1 20.0 2.0 12.8 2.2 24.1 2.0 0.0 0.4 0.7 0.0 0.5 0.1 0.3 0.4 0.0 0.1 0.2 0.3 0.3 0.4 0.0 0.1 0.1 0.0 21.0 39.2 28.7 18.5 15.3 22.1 41.4 37.2 35.5 27.9 31.7 43.0 10.2 35.3 11.7 56.8 3.0 15.9 22.7 8.7 13.1 28.0 18.3 9.3 22.2 12.8 15.3 11.0 106.3 23.5 5.1 41.1 7.9 14.5 63.4 21.8 17.8 16.7 17.4 14.9 20.6 11.1 11.6 14.8 21.4 40.2 0.0 22.0 20.3 33.0 3.1 23.5 24.6 15.8 8.2 0.8 5.9 79.4 14.6 2.4 37.4 22.5 4.3 23.6 15.5 33.2 176.8 20.6 21.3 23.0 4.7 20.2 17.1 11.5 17.4 66.9 0.0 19.8 17.9 11.1 7.2 11.8 16.6 21.2 7.5 11.1 11.1 34.0 OTULIN "FAM105B, FLJ34884" ENSG00000154124 "OTU deubiquitinase with linear linkage specificity" Q96BN8 5 14664664-14699850 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Angiogenesis, Immunity, Innate immunity, Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 26.8" "Cell type enhanced" "Detected in many" "dendritic cells: 70.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA051074 Uncertain Approved "Plasma membrane,Mitochondria" NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 20: HeLa - Mitochondria" "Cluster 24: Non-specific - Transcription regulation" Mitochondria "Plasma membrane" "HPA051074: AB_2681334" "unprognostic (4.81e-3)" "unprognostic (1.11e-1)" "unprognostic (4.00e-2)" "unprognostic (1.19e-2)" "unprognostic (7.48e-2)" "unprognostic (1.91e-2)" "unprognostic (7.94e-3)" "unprognostic (1.43e-1)" "unprognostic (2.48e-2)" "unprognostic (9.55e-2)" "unprognostic (1.02e-1)" "unprognostic (7.13e-2)" "prognostic unfavorable (2.59e-7)" "unprognostic (2.92e-2)" "unprognostic (2.28e-2)" "unprognostic (1.60e-1)" "unprognostic (5.02e-2)" 5.0 3.9 4.8 9.6 6.3 26.8 4.6 5.9 4.9 5.5 6.2 4.7 7.6 3.6 2.6 8.0 3.5 4.7 6.7 4.9 5.0 4.4 12.3 6.4 12.5 6.6 5.6 4.8 6.8 3.8 3.6 6.5 6.4 6.3 4.6 4.6 5.7 3.3 5.2 11.8 5.8 4.8 5.6 7.1 4.3 7.1 5.8 11.2 4.1 5.5 13.5 5.7 6.9 7.1 10.0 11.5 11.2 12.8 10.0 10.3 12.3 9.8 6.9 13.8 10.2 15.4 7.2 18.0 18.9 6.4 19.9 11.1 14.1 12.9 9.2 31.1 11.6 12.9 36.3 8.3 8.8 12.4 21.2 6.0 15.2 11.3 9.4 7.6 11.8 14.9 13.0 27.8 10.0 6.1 12.4 10.6 6.9 10.5 12.0 18.8 10.0 7.1 8.9 10.1 5.1 8.3 35.1 7.8 7.6 13.5 8.5 14.1 11.1 17.8 20.0 13.4 13.2 12.4 20.6 20.3 10.1 23.2 9.3 0.2 0.6 1.1 0.3 0.7 1.0 0.3 0.8 1.1 1.0 1.6 0.5 1.3 0.7 0.3 1.1 0.8 1.7 0.3 4.8 6.3 5.9 4.9 4.9 5.0 6.6 5.6 6.4 5.6 5.8 7.1 20.3 3.2 11.5 23.5 24.6 0.0 23.2 0.0 26.2 11.9 12.8 11.7 15.0 10.0 4.3 5.5 14.6 15.1 70.6 21.1 7.9 5.5 9.4 20.6 28.1 13.3 9.5 13.7 18.5 5.8 10.3 10.1 16.8 24.0 10.2 14.0 6.4 36.9 13.9 8.4 19.5 15.7 0.0 18.9 0.0 4.2 10.5 25.0 0.0 38.4 17.1 10.4 26.8 16.6 31.7 8.0 13.3 6.4 38.5 25.9 14.1 15.1 5.1 31.4 0.0 11.5 10.2 29.7 28.8 23.7 0.0 14.2 35.8 7.6 15.6 23.1 OTULINL "FAM105A, FLJ11127, NET20" ENSG00000145569 "OTU deubiquitinase with linear linkage specificity like" Q9NUU6 5 14581792-14616180 "Enzymes, Predicted membrane proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 30.3" "Cell type enhanced" "Detected in some" "Collecting duct cells: 29.5;dendritic cells: 36.7;Endometrial stromal cells: 16.6;Hofbauer cells: 100.7;Macrophages: 28.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HeLa: 17.7;HMC-1: 55.6;OE19: 16.1;THP-1: 16.9;U-937: 27.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046638 Uncertain Approved Nucleoli,Cytosol NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" "Nucleoli, Cytosol" "HPA046638: AB_2679731" "unprognostic (1.47e-1)" "unprognostic (6.64e-3)" "unprognostic (1.92e-2)" "unprognostic (1.15e-3)" "unprognostic (6.26e-2)" "unprognostic (1.13e-3)" "unprognostic (2.33e-2)" "unprognostic (2.27e-2)" "unprognostic (6.44e-2)" "unprognostic (2.42e-1)" "prognostic favorable (1.02e-4)" "unprognostic (2.13e-1)" "unprognostic (1.33e-2)" "unprognostic (2.38e-2)" "prognostic unfavorable (7.62e-4)" "unprognostic (3.14e-1)" "unprognostic (8.79e-3)" 3.1 2.7 1.2 6.8 1.1 30.3 4.1 1.3 1.6 3.8 4.8 12.3 6.6 1.5 1.4 1.7 1.4 2.7 0.9 1.1 1.8 3.6 1.4 13.1 5.4 2.3 1.5 2.0 7.6 1.2 2.5 4.2 2.1 8.3 13.3 0.5 1.4 10.0 0.4 1.7 9.4 2.5 2.4 7.9 3.3 2.5 1.9 3.4 2.8 0.8 3.6 5.2 3.1 3.6 0.0 0.8 1.6 0.0 0.3 0.0 6.9 2.0 1.8 0.5 1.0 2.8 1.7 0.1 1.1 0.9 2.8 0.1 3.7 1.6 0.7 1.1 4.9 4.6 17.7 0.4 1.7 0.1 55.6 0.1 0.3 0.2 0.0 0.0 0.1 2.9 0.0 7.1 0.2 1.4 0.0 1.7 2.5 16.1 11.9 0.5 0.7 2.0 0.0 13.9 6.0 7.0 0.9 0.6 0.0 1.7 0.6 16.9 0.0 0.9 4.4 0.4 1.6 0.0 0.0 0.1 1.0 27.2 0.4 0.2 33.4 0.3 5.5 16.2 7.3 0.1 6.7 7.2 33.8 0.1 9.0 9.1 8.6 19.2 12.7 25.0 12.8 24.6 1.2 1.1 1.3 1.6 1.1 1.8 2.3 1.5 2.1 2.4 1.9 3.6 10.2 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 7.4 7.9 0.0 0.0 0.0 29.5 0.0 0.9 36.7 0.0 1.9 0.4 0.0 0.9 16.6 1.1 0.0 0.0 0.0 6.2 2.2 1.4 0.0 1.2 0.0 0.5 0.0 0.0 100.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 28.3 0.0 0.0 12.9 0.0 0.0 0.0 0.0 1.2 0.0 0.0 4.4 0.0 0.0 3.5 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 1.4 8.8 0.2 0.0 0.0 PAN2 "hPAN2, KIAA0710, USP52" ENSG00000135473 "Poly(A) specific ribonuclease subunit PAN2" Q504Q3 12 56316223-56334053 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "mRNA processing" "Exonuclease, Hydrolase, Nuclease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 23: Testis - Cell cycle regulation" "Cluster 30: Epithelial cell lines - Translation" "Cluster 52: Non-specific - Transcription" "unprognostic (2.43e-1)" "unprognostic (3.78e-1)" "unprognostic (1.21e-2)" "unprognostic (2.55e-1)" "unprognostic (1.67e-1)" "unprognostic (9.10e-3)" "unprognostic (1.03e-1)" "unprognostic (7.28e-2)" "unprognostic (7.35e-3)" "unprognostic (3.80e-1)" "unprognostic (1.74e-3)" "unprognostic (4.23e-3)" "prognostic unfavorable (2.77e-4)" "unprognostic (4.19e-1)" "unprognostic (3.87e-1)" "unprognostic (2.10e-1)" "unprognostic (2.68e-2)" 6.6 8.7 4.2 5.8 6.1 7.4 7.4 6.0 6.0 8.3 6.9 8.0 9.9 9.1 14.1 5.0 9.7 6.6 7.1 4.1 4.5 7.6 16.0 7.3 8.5 5.3 5.2 12.7 10.0 14.1 11.6 8.2 5.4 6.7 8.2 16.0 7.9 8.2 6.9 8.3 8.7 7.5 4.7 10.1 9.5 13.5 5.7 16.8 14.8 6.7 10.0 7.0 6.7 7.9 4.3 6.4 15.5 4.9 13.3 15.0 10.1 3.2 4.4 7.1 3.2 3.9 8.3 11.8 12.2 6.3 3.8 8.8 18.6 12.3 4.0 5.2 8.8 15.1 6.6 3.8 11.7 3.3 7.8 14.0 16.3 7.6 22.0 18.7 5.4 24.2 10.3 28.4 4.2 9.4 11.3 7.9 5.2 7.2 4.2 9.7 11.0 21.5 7.0 3.4 12.1 11.0 6.2 7.9 8.0 17.2 10.2 6.4 2.3 7.0 7.0 3.3 3.0 23.9 10.3 7.8 8.7 6.8 6.2 3.2 3.3 1.3 1.3 4.4 1.9 1.6 1.1 1.9 4.2 1.3 2.2 2.7 0.2 2.3 2.2 1.7 1.7 2.0 4.2 6.1 6.0 6.0 4.1 4.5 5.3 5.2 5.4 4.7 5.7 7.9 9.7 9.6 17.0 19.2 11.1 5.1 5.4 3.8 6.8 27.4 9.5 10.2 9.8 2.8 8.3 5.5 27.1 8.2 7.9 5.4 1.9 3.7 1.8 8.6 9.4 9.4 14.4 13.3 11.0 2.2 4.8 7.2 18.3 13.7 6.3 15.0 10.4 18.3 5.4 15.2 13.9 10.8 4.1 7.0 5.0 2.6 11.1 8.2 1.8 9.4 5.2 7.3 3.1 10.1 32.1 2.8 8.7 6.4 9.2 4.1 7.3 3.5 13.4 17.1 6.6 11.4 6.9 26.9 7.6 7.1 3.8 5.1 6.6 12.6 9.5 3.6 PARK7 "DJ-1, DJ1, GATD2" ENSG00000116288 "Parkinsonism associated deglycase" Q99497 1 7954291-7985505 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, DNA damage, DNA repair, Fertilization, Inflammatory response, Stress response" "Chaperone, Hydrolase, Protease, RNA-binding" "Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004190, CAB005870" Supported Supported Nucleoplasm,Cytosol NA NA 35000000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Cytosol" "CAB005870: AB_444361, HPA004190: AB_1079566" "unprognostic (6.88e-3)" "unprognostic (7.50e-2)" "unprognostic (3.48e-2)" "unprognostic (1.16e-2)" "unprognostic (4.08e-2)" "unprognostic (5.68e-2)" "unprognostic (7.45e-2)" "unprognostic (9.63e-2)" "unprognostic (2.01e-1)" "unprognostic (1.66e-2)" "unprognostic (1.12e-1)" "unprognostic (2.02e-1)" "unprognostic (1.96e-3)" "unprognostic (8.17e-2)" "unprognostic (1.32e-1)" "unprognostic (1.30e-1)" "unprognostic (7.43e-2)" 249.4 373.6 283.5 213.7 290.0 205.0 235.7 292.9 403.4 201.1 327.7 252.5 145.8 212.2 278.0 161.0 203.2 162.9 388.0 285.5 296.6 311.0 397.6 181.6 269.2 289.6 286.0 234.2 308.5 387.6 283.6 174.1 291.7 234.9 194.9 273.8 240.9 185.6 771.4 127.1 170.5 199.1 295.2 188.2 234.2 139.6 288.1 217.9 286.3 541.8 249.7 226.5 171.2 299.7 537.0 452.5 467.1 523.2 459.8 442.6 218.4 476.7 434.4 450.4 360.3 419.9 549.4 633.1 534.2 505.1 328.6 367.1 483.2 625.3 579.3 574.5 526.2 683.0 678.6 674.5 403.8 662.9 418.6 421.3 262.4 459.8 547.4 359.2 478.2 340.1 676.8 471.7 633.0 485.0 474.3 868.7 376.1 653.6 465.4 366.7 598.0 888.7 714.7 269.7 527.7 447.4 470.4 728.0 798.4 370.1 414.9 503.7 459.3 412.8 344.6 395.5 539.5 452.8 788.4 938.8 551.5 1002.9 606.4 298.4 590.2 394.0 484.7 553.7 459.2 483.6 478.2 577.3 717.4 374.6 406.8 466.8 202.5 551.1 456.9 1378.2 874.4 1060.8 283.5 290.0 292.9 403.4 285.5 296.6 289.6 286.0 291.7 295.2 288.1 299.7 243.6 131.4 157.1 23.2 211.8 208.9 402.4 677.7 200.9 196.2 342.0 381.8 453.3 257.4 318.5 248.3 79.2 553.0 382.3 131.1 851.0 504.3 32.1 272.1 263.9 241.7 238.0 177.1 19.5 478.4 612.1 302.3 146.3 195.9 206.5 291.2 183.1 368.1 435.1 186.7 22.9 279.6 484.2 204.5 304.5 53.6 358.2 258.9 359.3 21.5 605.4 816.4 327.5 18.1 36.0 378.9 186.9 378.7 269.7 523.4 227.1 941.5 327.8 235.5 276.1 277.8 342.6 288.2 302.2 220.4 143.8 469.6 244.4 535.3 312.2 433.1 PGPEP1 "Pcp, PGP, PGP-I, PGPI" ENSG00000130517 "Pyroglutamyl-peptidase I" Q9NXJ5 19 18340598-18369950 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 73.9;Proximal enterocytes: 88.2;Proximal tubular cells: 85.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 28.4" "Lineage enriched" "Detected in all" 4 "granulocytes: 28.4" "Cell line enhanced" "Detected in many" "HMC-1: 58.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035368, HPA055277" Approved Approved "Golgi apparatus" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Golgi apparatus" "HPA035368: AB_10601388, HPA055277: AB_2682770" "unprognostic (9.52e-3)" "unprognostic (1.37e-2)" "unprognostic (6.95e-2)" "unprognostic (5.74e-3)" "unprognostic (5.29e-2)" "unprognostic (6.60e-2)" "unprognostic (1.96e-2)" "unprognostic (2.11e-3)" "prognostic favorable (6.80e-4)" "unprognostic (2.79e-2)" "prognostic favorable (1.71e-4)" "unprognostic (4.81e-3)" "prognostic favorable (3.71e-8)" "unprognostic (1.12e-2)" "unprognostic (1.66e-1)" "unprognostic (1.51e-1)" "unprognostic (1.20e-3)" 10.1 27.8 30.1 6.9 30.2 13.1 10.3 27.0 36.7 14.9 38.3 23.5 22.4 11.1 12.8 5.5 12.7 7.9 25.1 31.0 30.6 40.8 48.4 14.3 6.5 35.6 28.9 16.5 34.2 13.9 24.4 5.2 36.2 20.3 15.6 4.2 20.4 12.9 27.1 4.9 30.3 6.4 36.2 23.5 23.6 3.8 30.2 8.2 14.6 14.4 6.3 15.9 8.3 35.5 8.7 13.6 11.1 11.2 13.7 10.8 13.5 10.2 15.9 6.9 10.2 9.7 18.4 13.4 16.7 16.8 12.3 2.3 4.4 2.3 3.8 15.9 4.8 14.7 15.0 27.9 19.4 8.7 58.5 10.9 4.9 5.3 1.0 24.6 10.4 22.8 27.5 19.7 5.8 13.9 8.9 7.0 11.3 6.0 4.2 0.1 4.1 12.1 7.5 13.5 3.9 6.1 1.9 1.1 18.4 7.2 5.1 17.3 16.1 7.9 5.3 10.4 4.4 24.3 12.6 8.2 21.0 24.0 7.4 28.4 5.5 8.1 4.8 5.8 2.9 1.9 3.4 4.5 3.5 5.5 4.2 3.8 3.1 4.8 6.8 2.3 4.2 3.9 30.1 30.2 27.0 36.7 31.0 30.6 35.6 28.9 36.2 36.2 30.2 35.5 7.5 9.6 15.0 10.4 12.2 2.3 10.2 9.5 8.6 4.7 14.3 9.8 20.9 37.1 13.2 31.3 10.4 18.6 21.2 73.9 7.9 20.7 0.8 15.2 8.6 10.0 38.9 10.7 11.3 45.4 26.6 9.6 27.5 14.7 35.4 7.9 13.6 72.5 24.1 5.0 7.9 21.0 8.2 29.0 5.4 1.7 7.8 19.3 16.0 8.4 13.1 8.9 24.7 3.5 4.3 44.4 36.5 20.3 25.8 9.2 88.2 85.7 12.3 7.0 6.6 10.3 9.0 2.9 4.7 1.8 1.1 18.7 15.2 9.4 33.4 16.9 PGPEP1L ENSG00000183571 "Pyroglutamyl-peptidase I like" A6NFU8 15 98968229-99007792 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enriched" "Detected in some" 4 "skeletal muscle: 30.9" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 2.1;Distal tubular cells: 1.9;Early spermatids: 3.8;Excitatory neurons: 3.8;Inhibitory neurons: 3.3;Late spermatids: 1.7;Skeletal myocytes: 2.1;Spermatocytes: 2.7;Spermatogonia: 2.3" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in some" HPA041781 Uncertain NA NA "Cluster 46: Basophils - DNA binding" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 37: Myocytes - Muscle contraction" "HPA041781: AB_10795642" "unprognostic (2.48e-1)" "unprognostic (2.82e-2)" "unprognostic (8.26e-2)" "unprognostic (2.43e-3)" "unprognostic (7.18e-2)" "unprognostic (3.99e-2)" "unprognostic (1.69e-1)" "unprognostic (5.44e-2)" "unprognostic (9.78e-2)" "unprognostic (1.58e-1)" "unprognostic (4.53e-3)" "unprognostic (1.86e-1)" "unprognostic (2.62e-1)" "unprognostic (2.00e-2)" "unprognostic (1.65e-1)" 0.2 0.1 0.7 0.2 0.9 0.1 0.4 0.0 1.1 0.2 0.0 0.5 0.2 0.2 0.0 0.8 0.1 0.5 3.8 0.5 0.4 0.4 0.0 0.2 0.3 0.2 0.3 0.1 0.5 0.0 0.1 0.2 0.1 0.5 0.0 0.1 0.6 0.5 30.9 0.1 0.1 0.1 0.0 0.0 0.2 2.0 0.4 0.1 0.1 7.5 0.0 0.3 0.3 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.3 0.0 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.2 0.0 0.1 0.0 0.7 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.7 0.9 0.0 1.1 0.5 0.4 0.2 0.3 0.1 0.0 0.4 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.4 2.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.9 0.0 3.8 0.1 0.1 0.0 0.0 0.0 3.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.1 0.9 2.7 2.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 PIGK "GPI8, hGPI8" ENSG00000142892 "Phosphatidylinositol glycan anchor biosynthesis class K" Q92643 1 77088989-77219430 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "GPI-anchor biosynthesis" "Hydrolase, Protease, Thiol protease" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA056383, HPA057040" Uncertain "Intracellular and membrane" NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 1: Thyroid gland - Transcription" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "HPA056383: AB_2683109, HPA057040: AB_2683319" "unprognostic (2.43e-2)" "unprognostic (2.60e-1)" "unprognostic (4.07e-2)" "unprognostic (2.24e-2)" "unprognostic (3.65e-1)" "unprognostic (1.15e-1)" "prognostic unfavorable (4.68e-4)" "unprognostic (1.07e-1)" "unprognostic (5.19e-1)" "unprognostic (1.12e-1)" "unprognostic (4.17e-2)" "unprognostic (1.85e-2)" "unprognostic (1.76e-2)" "unprognostic (3.37e-1)" "unprognostic (1.38e-1)" "unprognostic (1.21e-1)" "unprognostic (8.12e-3)" 9.8 12.4 5.2 6.3 6.6 8.8 12.4 6.1 9.4 9.7 5.7 8.5 6.9 9.5 9.7 6.5 9.3 10.0 14.1 6.0 6.4 17.7 13.2 9.2 8.8 5.9 5.5 9.6 9.6 16.3 6.5 6.4 6.2 11.2 9.3 9.8 9.5 8.8 7.0 4.8 7.3 10.7 6.8 9.8 8.9 6.0 5.5 8.5 16.3 9.8 7.5 9.3 4.2 9.8 12.3 14.2 11.5 14.7 64.1 48.1 18.6 24.4 33.1 25.0 35.6 11.8 12.2 10.7 24.4 43.1 29.7 10.8 14.8 20.8 45.2 22.1 15.1 14.6 13.8 11.1 14.4 32.5 12.4 29.2 11.1 26.7 22.9 29.9 37.4 13.2 18.0 35.6 39.0 8.3 10.3 13.2 10.4 13.7 23.4 12.0 33.7 13.3 31.9 8.9 9.7 9.1 23.2 20.8 27.1 18.9 10.0 18.5 21.5 40.1 15.6 21.9 25.0 16.1 23.7 10.7 29.8 40.5 16.2 7.2 3.0 5.8 5.8 3.4 6.0 3.7 6.0 5.0 5.7 3.2 7.5 6.8 1.5 7.4 3.5 3.9 9.8 4.7 5.2 6.6 6.1 9.4 6.0 6.4 5.9 5.5 6.2 6.8 5.5 9.8 17.7 9.6 9.1 16.3 14.4 9.6 15.2 23.7 5.2 14.2 21.0 14.2 23.0 18.6 18.3 40.5 2.1 16.0 14.1 9.7 3.9 20.8 2.1 15.6 15.5 18.1 10.8 16.4 51.4 21.1 35.7 29.3 6.6 14.1 17.7 14.7 20.3 29.3 20.3 8.4 40.2 12.4 24.4 14.5 13.9 3.7 19.6 11.9 19.6 26.2 9.2 17.6 18.6 40.7 78.2 11.9 8.5 27.4 41.7 10.1 9.3 23.3 25.3 12.4 52.6 16.3 24.1 75.8 30.2 9.4 11.9 15.2 15.5 12.7 12.7 11.5 SCRN1 KIAA0193 ENSG00000136193 "Secernin 1" Q12765 7 29920104-29990289 "Enzymes, Predicted intracellular proteins" Exocytosis "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 159.0" "Cell type enhanced" "Detected in many" "Muller glia cells: 80.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "WM-115: 326.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024517 Enhanced Approved Cytosol No No 160000 "Cluster 51: Monocytes - Innate immune response" "Cluster 77: Retina - Visual perception" "Cluster 17: WM-115 - Nervous system development" "Cluster 5: Muller glia cells - Visual perception" Cytosol "HPA024517: AB_2184811" "prognostic unfavorable (8.32e-4)" "prognostic unfavorable (8.46e-4)" "unprognostic (1.45e-1)" "prognostic unfavorable (4.00e-5)" "unprognostic (1.87e-2)" "unprognostic (2.43e-1)" "unprognostic (1.13e-3)" "unprognostic (1.10e-1)" "unprognostic (2.29e-1)" "prognostic unfavorable (7.27e-4)" "unprognostic (1.09e-2)" "unprognostic (1.02e-1)" "prognostic favorable (1.15e-5)" "unprognostic (2.57e-2)" "unprognostic (2.10e-1)" "unprognostic (2.23e-1)" "prognostic unfavorable (2.60e-4)" 13.9 27.9 112.4 13.1 118.9 8.1 14.3 128.2 117.9 22.2 52.2 27.5 6.5 27.4 16.2 19.0 26.0 16.5 19.8 112.5 129.0 23.7 2.6 16.4 14.3 112.5 159.0 32.4 36.7 54.5 34.0 15.8 115.5 27.9 10.4 102.5 18.0 37.2 2.4 11.1 15.8 34.3 116.1 10.8 19.3 23.0 122.5 28.9 13.5 11.0 21.6 22.0 17.8 127.1 106.3 75.0 119.9 48.6 83.1 126.9 0.5 97.0 128.8 102.5 110.0 87.1 81.8 13.0 83.7 124.7 227.3 46.7 137.7 41.2 148.9 0.6 29.0 43.8 49.7 56.6 105.9 0.3 0.5 106.5 58.1 93.5 49.6 139.4 95.9 28.0 0.5 33.3 146.6 59.5 15.5 0.1 109.4 0.2 79.6 0.3 127.7 1.1 71.7 51.5 43.7 103.1 99.9 64.1 112.5 149.7 86.3 6.9 106.7 132.2 113.3 1.7 123.7 10.8 177.0 1.1 62.4 0.5 326.5 3.7 3.4 10.3 0.9 14.1 10.7 14.0 0.2 1.0 10.9 7.6 0.7 1.4 0.5 7.1 25.4 10.8 0.0 3.5 112.4 118.9 128.2 117.9 112.5 129.0 112.5 159.0 115.5 116.1 122.5 127.1 5.9 28.9 14.1 42.7 15.4 3.1 12.6 14.0 14.2 66.9 7.6 5.2 15.8 20.0 22.3 33.1 45.9 0.4 16.2 1.1 15.6 24.1 61.1 7.3 11.9 10.9 12.1 2.5 52.0 25.1 1.9 17.2 5.6 6.7 8.2 22.9 1.8 0.3 5.4 69.0 51.4 0.7 14.2 8.8 13.9 68.1 13.7 11.1 7.2 16.9 11.5 80.8 12.3 31.2 35.6 21.2 17.3 21.1 12.5 17.4 0.1 2.8 29.2 41.1 6.6 9.6 11.9 3.1 11.0 5.1 1.7 1.0 2.8 8.5 1.2 22.3 SCRN2 ENSG00000141295 "Secernin 2" Q96FV2 17 47837692-47841289 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 149.7;Proximal tubular cells: 332.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022934, HPA023434" Enhanced Supported "Nucleoplasm,Golgi apparatus" NA NA 370000 "Cluster 44: Non-specific - Transcription" "Cluster 7: Kidney - Transmembrane transport" "Cluster 25: RPMI-8226 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "Golgi apparatus" "HPA022934: AB_1856638, HPA023434: AB_1856639" "unprognostic (2.35e-2)" "unprognostic (1.42e-2)" "unprognostic (2.86e-1)" "unprognostic (6.14e-2)" "unprognostic (2.46e-2)" "unprognostic (1.73e-1)" "prognostic favorable (3.86e-4)" "unprognostic (4.63e-2)" "unprognostic (3.25e-2)" "unprognostic (5.77e-2)" "unprognostic (1.28e-3)" "unprognostic (8.72e-2)" "unprognostic (3.43e-2)" "unprognostic (5.28e-3)" "unprognostic (1.64e-1)" "unprognostic (1.20e-1)" "prognostic favorable (5.83e-4)" 81.2 22.9 18.9 11.1 19.4 13.4 48.9 18.8 22.3 28.2 22.0 23.8 43.8 24.5 11.5 19.2 26.5 12.0 31.9 18.5 20.6 68.6 37.2 17.4 12.9 19.9 19.6 25.4 26.4 25.4 31.5 12.9 18.8 28.5 10.4 6.5 33.8 19.7 38.1 22.1 36.7 10.2 20.1 34.0 21.5 10.6 19.4 12.0 39.9 25.0 10.1 22.2 23.3 20.1 28.0 43.8 12.1 11.0 33.7 25.7 36.6 13.7 27.6 20.6 21.0 32.5 33.2 15.3 27.5 7.1 11.0 14.7 3.9 24.6 6.9 37.6 29.7 15.5 33.8 29.2 12.0 7.9 12.7 25.7 18.1 12.8 9.8 31.5 23.5 35.6 5.4 18.2 28.9 25.4 24.6 12.8 6.0 12.1 17.5 32.7 9.0 62.4 16.9 12.9 8.9 37.6 8.0 17.3 17.8 8.3 37.9 14.5 10.7 18.2 20.8 5.6 6.6 70.2 9.8 7.7 52.1 13.2 4.2 24.5 19.9 43.4 24.6 21.1 24.1 24.8 20.4 24.2 25.7 25.3 31.7 17.8 5.4 29.3 10.8 30.1 23.0 16.5 18.9 19.4 18.8 22.3 18.5 20.6 19.9 19.6 18.8 20.1 19.4 20.1 21.9 38.5 29.9 15.0 18.7 15.7 31.5 41.8 20.5 12.0 24.5 25.7 19.3 15.7 35.9 16.5 10.4 43.1 12.4 33.2 74.3 27.7 3.9 16.9 10.0 24.6 22.3 7.2 12.4 61.0 9.3 25.7 17.3 12.4 16.5 22.1 24.3 26.7 22.7 20.2 10.5 33.6 48.8 11.1 13.7 2.8 33.2 12.8 42.7 7.5 13.9 28.8 26.8 11.1 6.0 33.3 36.5 16.6 30.9 14.1 149.7 332.7 40.9 16.8 6.6 19.1 16.0 5.2 16.7 21.9 11.5 33.8 21.6 23.9 40.7 27.0 SCRN3 FLJ23142 ENSG00000144306 "Secernin 3" Q0VDG4 2 174395730-174429575 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034689, HPA034690" Approved Approved Vesicles,Cytosol NA NA 27000 "Cluster 1: Neutrophils - Mixed function" "Cluster 8: Non-specific - Mitochondria" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Vesicles, Cytosol" "HPA034689: AB_2674282, HPA034690: AB_10670574" "unprognostic (5.39e-3)" "unprognostic (4.58e-2)" "unprognostic (2.06e-2)" "unprognostic (3.58e-1)" "unprognostic (1.91e-1)" "unprognostic (1.89e-1)" "unprognostic (9.89e-2)" "unprognostic (1.57e-1)" "unprognostic (5.14e-2)" "unprognostic (5.85e-2)" "unprognostic (8.81e-2)" "unprognostic (1.30e-1)" "unprognostic (6.62e-3)" "unprognostic (1.75e-1)" "unprognostic (1.31e-1)" "unprognostic (5.57e-2)" "unprognostic (1.57e-1)" 16.4 16.4 11.8 9.9 14.4 5.2 13.5 14.7 16.0 9.5 7.0 12.9 18.5 11.9 11.4 16.2 10.4 11.2 26.0 10.8 13.6 20.2 22.0 12.2 11.4 14.6 13.4 13.2 14.7 27.7 14.0 13.1 13.6 15.2 13.2 22.8 11.0 12.5 40.5 13.8 14.3 14.0 12.9 11.8 12.4 10.6 14.1 12.4 20.3 35.8 12.1 10.4 8.3 18.5 15.9 9.7 25.8 22.8 18.8 21.1 13.7 24.1 19.0 18.2 22.0 9.6 11.4 3.0 15.6 24.2 14.0 15.5 19.3 21.1 23.9 34.8 17.8 29.7 21.1 7.5 27.8 22.8 15.0 23.5 25.4 34.4 24.5 20.4 21.8 16.7 20.2 11.1 25.0 18.0 18.9 22.2 12.0 35.4 41.0 9.3 25.7 17.5 21.2 16.5 16.0 44.5 16.6 16.2 30.7 26.4 21.8 21.7 15.7 20.9 10.9 25.6 21.0 29.4 32.8 0.5 22.9 11.2 21.8 7.2 5.2 2.2 4.8 3.3 3.4 8.6 5.1 4.6 5.1 11.0 7.8 6.3 20.0 6.9 4.3 8.0 5.6 2.6 11.8 14.4 14.7 16.0 10.8 13.6 14.6 13.4 13.6 12.9 14.1 18.5 7.8 9.6 15.6 18.6 7.0 3.6 12.1 23.7 12.5 12.8 7.9 6.3 22.8 4.3 12.5 9.2 10.4 10.7 3.8 8.4 13.7 9.1 5.1 9.4 8.3 6.0 6.0 11.6 21.0 9.8 6.3 6.9 11.2 5.4 8.8 9.5 8.6 8.7 9.3 18.5 26.3 7.3 20.3 5.8 2.2 4.0 4.7 6.2 3.6 6.5 6.1 22.6 7.2 27.6 25.7 12.2 4.0 6.8 10.3 5.4 9.9 12.5 13.6 15.0 0.0 8.2 7.1 18.9 7.1 20.4 4.8 6.8 5.8 13.0 6.4 9.7 SENP1 ENSG00000079387 "SUMO specific peptidase 1" Q9P0U3 12 48042897-48106079 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "salivary gland: 32.5;testis: 61.8" "Cell type enhanced" "Detected in many" "Spermatocytes: 86.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA011765, HPA046491" Supported "Nucleoplasm,Focal adhesion sites" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 23: Testis - Cell cycle regulation" "Cluster 32: U-937 - Innate immune response" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Nucleoplasm "Focal adhesion sites" "HPA011765: AB_1079907, HPA046491: AB_2679672" "unprognostic (2.66e-2)" "unprognostic (6.51e-2)" "unprognostic (3.14e-1)" "unprognostic (5.69e-2)" "unprognostic (2.83e-1)" "unprognostic (1.09e-1)" "prognostic unfavorable (7.72e-5)" "unprognostic (6.48e-2)" "unprognostic (2.44e-3)" "unprognostic (8.20e-3)" "unprognostic (2.57e-1)" "unprognostic (2.23e-1)" "prognostic unfavorable (8.37e-4)" "unprognostic (7.61e-2)" "unprognostic (3.02e-1)" "unprognostic (1.01e-1)" "unprognostic (1.28e-1)" 5.0 3.6 3.1 9.1 3.9 14.4 5.6 8.3 3.7 6.2 1.9 4.9 4.8 7.5 5.1 7.5 4.7 5.5 3.8 2.7 5.0 3.8 3.8 4.6 12.0 3.0 3.6 5.5 4.4 6.3 3.3 6.5 3.7 4.8 6.8 6.5 32.5 4.7 3.7 6.8 4.7 7.0 2.2 6.3 4.8 61.8 3.4 12.2 5.8 4.3 12.9 6.1 3.9 5.0 13.8 17.7 22.4 16.3 6.4 9.8 15.7 14.9 17.1 25.8 20.7 22.2 22.3 38.0 12.8 13.9 9.9 13.0 28.0 13.0 25.7 34.6 11.4 33.9 17.9 10.9 10.1 32.2 22.4 7.4 10.4 22.7 20.1 11.4 13.7 25.2 30.2 15.9 13.4 12.0 40.1 11.2 20.0 9.5 12.8 36.6 23.6 19.1 7.2 17.3 22.8 15.4 21.9 13.2 8.8 12.7 20.6 14.4 12.2 21.1 18.4 12.5 16.4 18.4 32.5 36.7 13.3 71.4 10.0 0.8 0.8 2.9 1.6 1.1 2.1 1.0 1.6 1.6 1.4 1.8 1.4 1.5 1.6 1.6 0.8 1.5 1.9 1.0 3.1 3.9 8.3 3.7 2.7 5.0 3.0 3.6 3.7 2.2 3.4 5.0 11.2 9.6 8.9 18.9 14.3 3.7 4.7 4.7 6.8 7.9 6.7 4.7 3.2 4.3 7.6 3.7 4.2 4.0 9.1 3.6 3.9 3.9 16.7 5.6 11.6 9.1 3.5 11.1 14.0 6.5 3.4 7.3 7.7 5.0 6.3 9.8 6.8 6.6 4.5 15.2 15.9 4.2 8.2 9.5 4.2 6.0 6.2 7.7 1.8 15.0 7.2 5.2 5.2 17.6 17.8 5.8 1.9 6.8 13.5 4.4 2.8 3.7 4.6 8.7 0.0 9.8 8.3 86.5 31.0 8.5 6.1 2.7 12.2 7.4 4.2 3.8 SENP2 "AXAM2, DKFZp762A2316, KIAA1331, SMT3IP2" ENSG00000163904 "SUMO specific peptidase 2" Q9HC62 3 185582496-185633551 "Enzymes, Plasma proteins, Predicted intracellular proteins, Transporters" "mRNA transport, Protein transport, Translocation, Transport, Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 249.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029247, HPA029248" Approved Supported Cytosol NA NA "Cluster 34: Basophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 5: NTERA-2 - Transcription" "Cluster 29: Early spermatids - Spermatogenesis" Cytosol "HPA029247: AB_10599305, HPA029248: AB_10601855" "unprognostic (4.57e-2)" "unprognostic (1.84e-2)" "unprognostic (6.80e-2)" "prognostic unfavorable (7.98e-5)" "unprognostic (7.85e-2)" "unprognostic (2.90e-2)" "unprognostic (4.41e-3)" "unprognostic (1.45e-1)" "unprognostic (1.59e-1)" "unprognostic (1.46e-1)" "unprognostic (1.85e-1)" "unprognostic (8.41e-3)" "unprognostic (5.12e-2)" "unprognostic (6.92e-2)" "unprognostic (1.60e-1)" "unprognostic (1.92e-1)" "unprognostic (1.56e-1)" 7.4 7.3 13.4 4.4 15.8 10.7 7.5 13.3 16.2 6.0 12.0 7.8 6.0 6.1 9.7 6.5 7.2 4.5 8.3 13.9 13.1 7.3 9.5 6.4 6.2 12.9 13.6 10.0 7.4 9.6 10.5 9.0 12.4 6.6 6.1 12.8 7.6 6.3 18.9 9.2 6.6 4.8 12.2 6.7 8.0 15.1 14.2 8.1 7.2 13.0 6.0 7.1 6.3 14.4 24.4 4.6 11.6 13.4 20.6 13.8 15.1 10.9 12.6 13.8 14.6 18.3 7.5 13.2 20.3 10.2 23.6 12.6 24.3 9.0 20.3 9.7 11.6 8.9 9.8 11.0 10.9 13.2 5.6 8.6 13.3 7.8 9.5 10.2 9.6 12.5 10.8 18.1 12.0 12.0 11.4 14.7 42.4 12.3 8.1 13.1 15.8 22.1 7.7 7.9 11.9 13.4 9.3 20.4 18.3 23.0 27.8 17.5 6.1 9.0 9.8 16.4 17.7 20.9 26.8 23.8 14.9 13.9 12.5 5.1 1.3 2.6 1.6 1.3 1.6 1.3 1.3 1.3 1.0 1.9 1.5 1.5 3.4 2.3 1.6 2.0 1.3 0.9 13.4 15.8 13.3 16.2 13.9 13.1 12.9 13.6 12.4 12.2 14.2 14.4 12.3 28.9 27.4 17.9 21.2 10.8 23.7 12.6 6.2 22.8 21.6 15.4 24.2 11.5 26.2 9.2 31.3 25.0 22.6 15.7 5.9 12.9 249.6 26.3 12.0 12.8 5.4 11.1 42.9 15.2 19.9 16.1 15.3 25.2 10.8 21.3 17.2 20.5 13.2 11.8 43.0 15.1 14.2 12.5 9.1 43.0 22.7 11.1 17.8 26.2 13.6 17.8 21.6 41.2 41.3 17.9 6.6 17.7 25.7 17.0 24.2 18.2 28.8 38.1 19.7 23.2 16.3 84.2 31.8 13.4 12.5 39.7 18.2 33.7 15.8 22.5 SENP3 "DKFZP586K0919, DKFZp762A152, SMT3IP1, SSP3, Ulp1" ENSG00000161956 "SUMO specific peptidase 3" Q9H4L4 17 7561919-7571969 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 22.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" HPA060290 Supported Supported Nucleoplasm,Nucleoli Yes No "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 9: Photoreceptor cells - Phototransduction" "Nucleoplasm, Nucleoli" "HPA060290: AB_2684244" "unprognostic (5.68e-2)" "unprognostic (2.39e-1)" "unprognostic (1.65e-1)" "unprognostic (1.01e-1)" "unprognostic (3.34e-1)" "unprognostic (3.48e-1)" "unprognostic (1.30e-3)" "unprognostic (2.82e-1)" "unprognostic (7.37e-2)" "unprognostic (3.72e-2)" "prognostic favorable (6.22e-5)" "unprognostic (2.71e-2)" "unprognostic (1.96e-1)" "unprognostic (1.42e-1)" "unprognostic (1.37e-1)" "unprognostic (8.21e-2)" "unprognostic (2.56e-2)" 24.2 24.0 43.7 21.0 42.6 25.4 23.7 38.5 47.9 23.7 38.5 32.4 21.2 26.7 27.4 25.4 25.9 19.3 25.2 42.6 39.8 34.1 20.5 28.6 26.5 40.4 42.2 26.8 26.4 38.1 26.4 22.5 41.1 23.0 25.4 24.7 24.8 26.0 33.5 28.6 25.2 28.9 39.5 28.3 27.0 29.0 44.0 33.8 23.9 30.9 31.2 29.7 21.8 42.0 76.4 90.8 52.7 82.5 58.6 42.8 54.8 54.8 56.0 93.4 87.2 54.9 32.5 90.3 52.6 72.7 62.3 72.0 114.4 85.8 78.0 63.7 105.0 46.7 74.8 56.9 79.1 44.0 57.9 55.1 86.5 107.1 103.5 53.3 76.0 102.1 61.5 24.7 73.0 51.4 107.9 33.6 64.2 70.9 54.5 97.1 48.8 52.4 62.9 44.0 52.5 67.6 55.3 52.7 60.0 66.6 44.1 28.5 40.5 53.0 45.9 51.3 119.0 36.3 40.4 57.3 53.9 45.7 80.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 43.7 42.6 38.5 47.9 42.6 39.8 40.4 42.2 41.1 39.5 44.0 42.0 4.5 3.2 5.4 0.0 4.9 8.5 6.4 1.6 10.2 6.1 6.7 11.0 7.1 7.2 3.6 1.8 22.9 3.0 4.8 2.6 0.0 2.3 1.4 4.0 4.2 4.7 6.6 1.3 0.0 2.4 2.3 3.8 3.6 4.7 1.3 5.2 8.2 2.7 1.5 6.7 0.0 3.0 2.0 6.0 6.4 0.7 4.1 4.9 3.6 0.0 4.7 5.5 4.1 0.0 0.0 2.1 0.8 2.2 6.4 6.1 4.0 1.1 2.1 7.3 0.0 5.2 4.4 3.7 4.0 7.4 11.6 4.1 4.9 3.0 3.7 6.4 SENP5 MGC27076 ENSG00000119231 "SUMO specific peptidase 5" Q96HI0 3 196867856-196934714 "Enzymes, Predicted intracellular proteins" "Cell cycle, Cell division, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 16: U-266 - Nucleosome" "Cluster 44: Endometrium - Transcription" "unprognostic (4.07e-2)" "unprognostic (4.91e-3)" "unprognostic (7.63e-2)" "prognostic unfavorable (4.04e-4)" "unprognostic (4.13e-1)" "unprognostic (1.08e-1)" "prognostic unfavorable (4.15e-4)" "unprognostic (2.95e-1)" "unprognostic (2.20e-1)" "unprognostic (2.88e-1)" "unprognostic (2.89e-1)" "unprognostic (9.57e-3)" "prognostic unfavorable (2.14e-5)" "unprognostic (2.02e-1)" "unprognostic (1.62e-1)" "unprognostic (1.62e-2)" "unprognostic (6.71e-2)" 8.1 7.0 12.3 8.3 12.2 15.8 8.1 14.4 14.0 10.6 9.9 10.3 5.8 8.4 7.9 8.5 9.1 7.3 9.3 13.0 14.6 7.8 10.1 9.9 9.0 13.3 13.1 10.4 8.1 8.9 10.2 9.1 14.3 9.3 7.0 17.5 7.7 7.4 11.9 9.4 8.3 7.8 11.3 10.5 8.2 20.8 12.7 10.6 8.3 12.2 11.5 9.0 9.8 15.9 26.0 11.1 18.1 16.4 15.0 17.8 14.7 16.2 17.1 17.1 27.2 20.2 10.0 24.3 44.1 17.6 29.1 17.8 18.9 8.6 27.5 13.1 13.3 32.8 17.1 14.3 17.4 27.1 14.8 15.5 22.7 17.4 18.4 12.4 16.9 21.0 22.2 36.1 20.2 22.1 26.1 16.0 14.2 14.0 23.4 16.5 14.7 16.6 8.4 14.5 11.3 15.0 18.9 20.1 19.8 18.0 33.8 20.5 19.3 16.5 17.2 23.0 33.5 38.6 73.6 51.4 22.4 21.7 19.3 16.3 6.5 6.3 7.1 7.1 6.4 7.4 6.8 7.0 4.3 7.0 6.3 6.7 12.5 6.5 8.1 6.9 5.9 3.6 12.3 12.2 14.4 14.0 13.0 14.6 13.3 13.1 14.3 11.3 12.7 15.9 25.7 22.4 12.6 43.4 27.7 60.8 28.4 8.6 16.5 28.6 22.7 13.0 14.6 12.8 13.2 9.2 16.7 18.3 33.4 19.9 11.7 16.0 42.9 22.1 26.9 21.6 21.6 19.3 71.2 14.2 15.7 21.1 18.8 27.5 26.6 25.9 22.5 17.6 13.4 28.6 69.1 16.6 8.2 20.4 41.4 48.0 16.1 17.4 14.2 48.7 18.7 13.8 27.8 50.8 57.3 27.4 19.4 16.6 24.4 21.4 13.3 20.5 11.2 30.5 26.3 25.8 23.9 67.5 56.8 14.3 62.1 22.8 25.7 13.7 13.8 36.1 SENP6 "KIAA0797, SUSP1" ENSG00000112701 "SUMO specific peptidase 6" Q9GZR1 6 75601509-75718281 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024376 Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 34: Non-specific - Transcription" "Cluster 1: K-562 - Erythropoiesis" "Cluster 59: Non-specific - Transcription" Nucleoplasm Cytosol "HPA024376: AB_1856678" "unprognostic (9.86e-2)" "unprognostic (1.20e-2)" "unprognostic (4.84e-2)" "unprognostic (1.87e-2)" "unprognostic (6.38e-3)" "unprognostic (7.33e-2)" "unprognostic (1.13e-2)" "unprognostic (2.97e-1)" "unprognostic (3.93e-2)" "unprognostic (5.32e-3)" "unprognostic (7.81e-2)" "unprognostic (9.24e-2)" "prognostic unfavorable (6.09e-4)" "unprognostic (1.78e-1)" "unprognostic (1.74e-1)" "prognostic unfavorable (2.83e-5)" "unprognostic (1.72e-1)" 25.1 22.6 12.8 24.6 16.8 37.9 31.4 47.6 15.5 28.6 7.5 26.6 20.9 33.0 22.1 25.3 26.8 26.0 22.6 9.6 14.3 28.5 28.0 26.4 28.5 11.9 11.9 40.5 27.0 39.4 22.3 33.4 12.8 29.3 26.0 31.4 21.8 28.9 25.5 25.2 20.5 31.9 12.3 28.9 24.9 33.8 12.0 32.4 41.9 30.1 30.4 29.7 21.2 22.3 23.8 24.5 54.3 39.1 41.3 54.6 40.3 41.9 46.5 34.6 43.1 33.9 22.4 40.1 38.6 48.7 40.9 29.8 51.6 28.0 53.1 59.2 44.2 60.8 28.9 31.7 57.3 53.5 42.8 42.6 45.6 32.6 71.8 41.9 58.2 32.8 74.9 43.2 43.0 29.0 21.4 28.6 33.1 31.9 20.4 39.7 28.7 59.0 36.7 35.0 47.2 48.7 35.8 31.3 36.4 43.5 28.2 50.1 49.0 30.8 33.4 15.9 43.8 48.9 52.4 31.4 15.4 49.8 33.1 7.5 8.0 20.8 7.3 8.4 10.5 9.1 7.4 9.9 8.9 10.5 10.5 9.6 14.9 10.1 14.7 11.0 6.9 6.3 12.8 16.8 47.6 15.5 9.6 14.3 11.9 11.9 12.8 12.3 12.0 22.3 76.7 67.3 128.3 158.0 74.0 46.5 65.0 27.6 78.6 58.8 53.0 59.6 76.7 31.5 70.9 29.5 91.8 33.0 73.8 43.2 17.6 33.7 40.4 62.9 78.1 57.9 27.6 50.5 152.6 33.7 29.4 69.3 51.0 62.9 65.1 74.2 42.1 32.0 29.5 60.6 177.3 35.6 24.4 43.2 41.5 35.6 70.8 57.7 35.6 149.9 68.4 56.6 50.4 218.1 228.9 32.1 29.9 63.2 62.8 63.4 32.6 26.8 47.2 65.7 26.3 98.9 73.7 107.7 61.7 61.4 48.4 41.2 67.2 66.0 46.3 66.8 SENP7 ENSG00000138468 "SUMO specific peptidase 7" Q9BQF6 3 101324205-101513241 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Inhibitory neurons: 109.6;Oligodendrocyte precursor cells: 157.3;Oligodendrocytes: 134.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 44.1" "Lineage enriched" "Detected in all" 4 "granulocytes: 44.1" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027259, HPA071998" Approved Supported "Nucleoplasm,Nuclear bodies,Centrosome,Cytosol" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 34: Non-specific - Transcription" "Cluster 12: NES - Nervous system development" "Cluster 68: Oligodendrocytes - Mixed function" Nucleoplasm "Nuclear bodies, Centrosome, Cytosol" "HPA027259: AB_1856679, HPA071998: " "unprognostic (1.50e-1)" "unprognostic (6.12e-2)" "unprognostic (2.78e-2)" "unprognostic (7.31e-2)" "unprognostic (2.44e-2)" "prognostic favorable (4.23e-4)" "unprognostic (1.38e-3)" "unprognostic (9.25e-3)" "unprognostic (8.80e-2)" "unprognostic (2.24e-1)" "unprognostic (7.77e-3)" "unprognostic (1.94e-1)" "unprognostic (9.85e-2)" "unprognostic (8.08e-3)" "unprognostic (3.27e-1)" "unprognostic (9.03e-2)" "unprognostic (2.23e-2)" 15.1 9.7 9.7 13.7 12.7 24.7 16.9 21.8 11.8 15.8 9.7 12.5 7.3 26.8 14.7 7.8 16.1 14.2 9.5 9.3 12.3 11.4 8.7 12.8 23.1 13.9 11.7 26.3 12.8 16.9 10.2 19.4 14.0 12.7 10.8 26.0 8.9 11.5 11.2 20.8 12.4 14.7 10.1 16.9 14.1 9.1 11.5 20.5 17.5 11.2 17.7 11.8 11.4 20.3 9.2 6.1 29.4 16.4 5.6 8.2 5.3 5.2 3.8 8.5 10.4 4.0 8.3 7.0 7.9 5.1 7.8 9.1 9.4 4.8 17.0 13.0 2.7 12.7 5.1 5.5 4.5 7.4 12.2 6.4 8.5 4.3 9.6 7.6 12.2 13.4 10.5 17.6 8.1 6.1 13.7 8.6 6.0 4.8 6.3 15.2 8.0 6.4 10.1 5.2 11.3 8.8 4.8 4.8 6.5 15.0 8.0 9.8 10.2 11.8 7.1 3.9 5.2 12.2 7.8 16.4 4.1 9.7 9.8 44.1 5.9 5.9 5.8 5.4 7.3 6.4 7.8 5.8 4.8 9.0 10.3 7.1 17.3 9.3 6.3 4.1 6.9 6.1 9.7 12.7 21.8 11.8 9.3 12.3 13.9 11.7 14.0 10.1 11.5 20.3 44.5 16.0 24.9 78.4 33.0 9.1 8.4 7.4 21.1 48.3 14.4 12.2 21.6 2.8 18.4 16.5 20.9 5.8 30.8 5.4 5.9 8.1 4.1 33.1 48.5 28.4 13.1 18.7 62.4 5.2 2.7 23.4 21.4 34.1 37.2 28.6 32.9 10.3 8.2 52.2 109.6 6.5 12.2 20.5 9.5 4.0 18.3 19.1 10.6 80.6 13.6 16.7 35.0 157.3 134.4 6.9 4.1 19.5 23.5 4.8 7.0 8.5 27.5 33.8 46.0 29.7 23.3 22.8 19.9 13.4 9.9 2.5 41.0 21.1 5.9 6.1 SENP8 "DEN1, HsT17512, NEDP1, PRSC2" ENSG00000166192 "SUMO peptidase family member, NEDD8 specific" Q96LD8 15 72114258-72143692 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 15.6" "Group enriched" "Detected in many" 11 "Early spermatids: 86.5;Late spermatids: 222.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036273 Approved Approved Nucleoplasm,Vesicles NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Vesicles" "HPA036273: AB_10669985" "unprognostic (1.83e-2)" "unprognostic (1.78e-1)" "unprognostic (9.85e-4)" "unprognostic (5.43e-2)" "unprognostic (1.49e-1)" "unprognostic (6.09e-3)" "unprognostic (3.06e-2)" "unprognostic (4.35e-2)" "unprognostic (1.06e-1)" "unprognostic (2.04e-1)" "unprognostic (3.11e-2)" "unprognostic (1.19e-1)" "unprognostic (8.46e-12)" "unprognostic (1.24e-1)" "unprognostic (1.12e-1)" "unprognostic (1.85e-2)" "unprognostic (1.54e-2)" 1.1 1.7 2.7 1.1 2.4 2.8 2.0 1.1 3.1 1.7 0.0 1.9 1.8 1.7 3.3 2.3 2.5 1.9 4.0 2.2 2.1 4.4 2.5 1.5 1.5 1.4 1.7 2.4 1.5 2.4 2.1 1.7 1.9 2.1 1.9 4.6 1.6 1.7 6.3 1.6 1.5 1.6 0.4 1.5 2.0 15.6 1.7 1.5 5.0 5.7 1.2 1.7 1.0 2.6 1.5 2.7 4.7 3.8 5.6 6.9 2.7 4.1 2.5 2.2 2.0 2.1 3.4 1.5 5.7 2.4 4.0 3.4 7.4 5.9 3.3 1.6 4.0 2.5 3.7 1.9 3.9 2.8 1.3 3.3 5.8 1.4 6.2 2.9 2.1 4.4 3.7 2.7 5.4 3.8 2.9 3.7 4.0 3.4 2.5 1.9 4.2 3.3 6.0 2.6 5.8 2.0 4.4 3.3 4.2 5.6 5.1 2.1 2.2 4.5 1.7 7.8 2.0 2.2 2.9 1.8 2.1 4.0 3.3 1.1 0.9 0.7 0.8 2.2 1.1 1.9 1.3 1.2 2.9 0.6 1.5 1.8 0.3 3.5 3.2 0.8 1.1 1.0 2.7 2.4 1.1 3.1 2.2 2.1 1.4 1.7 1.9 0.4 1.7 2.6 1.2 6.4 5.3 3.9 0.4 0.3 1.4 2.5 1.2 4.5 2.4 2.4 5.4 1.5 4.5 1.8 4.2 6.7 0.3 1.5 13.7 3.3 86.5 2.5 2.7 1.8 1.2 3.2 4.6 1.7 3.4 2.6 4.1 2.6 0.0 3.4 1.8 1.5 2.1 1.7 6.1 1.5 2.0 2.6 0.6 222.9 1.8 1.7 0.0 2.8 3.8 10.6 0.0 6.0 4.0 1.4 3.2 1.2 0.2 1.7 2.3 8.1 6.0 4.0 0.0 2.3 1.3 10.7 12.6 1.4 0.4 7.8 1.0 3.0 2.2 1.0 TINAG ENSG00000137251 "Tubulointerstitial nephritis antigen" Q9UJW2 6 54307859-54390142 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Cell adhesion" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 8 "kidney: 110.4" "Cell type enhanced" "Detected in some" "Distal enterocytes: 48.6;Distal tubular cells: 23.5;Proximal enterocytes: 72.5;Proximal tubular cells: 207.1" "Cancer enriched" "Detected in some" 4 "renal cancer: 15.8" "Group enriched" "Detected in some" 6 "medulla oblongata: 1.7;pons: 1.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 33 "RPTEC TERT1: 91.7" "Not detected" "Not detected" "Not detected" "Not detected" "HPA035427, HPA073753" Approved "Secreted to extracellular matrix" NA NA 40000 "Cluster 7: Kidney - Transmembrane transport" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA035427: AB_10601822, HPA073753: " "unprognostic (7.62e-3)" "unprognostic (1.12e-2)" "prognostic unfavorable (2.05e-5)" "unprognostic (7.27e-2)" "unprognostic (5.99e-3)" "prognostic favorable (8.75e-5)" "unprognostic (7.10e-2)" 0.0 0.0 0.1 0.8 0.1 0.0 0.0 0.0 0.2 0.0 0.0 14.0 11.7 0.0 0.0 0.0 0.0 1.7 0.1 0.2 0.0 110.4 0.0 0.0 0.0 1.7 0.1 0.0 0.0 0.0 0.0 0.0 1.6 0.0 13.8 0.0 0.0 0.0 0.2 0.0 14.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 91.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.2 0.2 0.0 1.7 0.1 1.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 7.3 0.0 0.0 0.0 48.6 23.5 0.0 1.0 0.1 0.0 0.0 9.7 0.0 2.8 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 6.6 0.0 0.0 0.0 0.1 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 15.3 0.0 0.0 0.0 72.5 207.1 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.3 0.0 18.4 0.0 TINAGL1 "ARG1, LCN7, LIECG3, P3ECSL, TINAGRP" ENSG00000142910 "Tubulointerstitial nephritis antigen like 1" Q9GZM7 1 31576485-31587686 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 1235.1;Sertoli cells: 427.3;Syncytiotrophoblasts: 1946.1" "Cancer enhanced" "Detected in all" "urothelial cancer: 87.8" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "basophil: 2.0" "Lineage enriched" "Detected in single" 4 "granulocytes: 2.0" "Cell line enhanced" "Detected in many" "BEWO: 322.7;CAPAN-2: 178.9;EFO-21: 403.6;HaCaT: 181.4;HBEC3-KT: 211.9;HUVEC TERT2: 173.4;TIME: 376.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA048695 Approved "Secreted to extracellular matrix" NA NA 370000 "Cluster 17: Basophils - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 38: EFO-21 - Unknown function" "Cluster 47: Cytotrophoblasts - Unknown function" "HPA048695: AB_2680497" "unprognostic (1.27e-1)" "unprognostic (2.94e-2)" "unprognostic (7.53e-2)" "unprognostic (1.80e-3)" "unprognostic (2.74e-1)" "unprognostic (1.72e-3)" "unprognostic (8.29e-3)" "unprognostic (6.02e-3)" "unprognostic (4.18e-1)" "unprognostic (6.96e-2)" "unprognostic (7.02e-3)" "unprognostic (1.22e-1)" "prognostic favorable (3.65e-6)" "unprognostic (7.42e-2)" "unprognostic (6.64e-2)" "prognostic favorable (9.64e-4)" "unprognostic (3.43e-2)" 173.7 40.8 19.0 18.5 17.7 0.9 150.5 17.9 19.9 86.8 16.4 83.2 26.7 101.8 10.7 31.0 82.4 23.9 230.7 15.2 17.9 177.7 22.7 85.7 8.5 19.6 18.3 38.8 31.0 13.2 25.3 183.6 19.8 71.2 16.5 1.0 63.8 40.6 46.6 37.0 51.6 36.5 16.4 119.6 66.4 6.2 21.2 3.8 115.1 30.6 5.3 88.4 70.2 17.1 96.6 0.2 0.0 0.5 0.8 0.2 322.7 14.9 1.9 0.7 0.4 44.5 178.9 0.2 403.6 13.4 7.0 181.4 0.2 211.9 0.1 0.7 0.1 0.1 7.3 11.5 4.5 0.1 0.5 0.2 37.9 0.0 7.6 0.1 173.4 0.1 2.4 0.4 0.0 0.0 0.7 0.6 0.9 52.6 6.1 0.4 0.1 0.4 57.0 72.6 0.4 0.5 38.0 125.6 4.2 18.8 7.5 0.3 376.6 0.3 91.6 0.7 2.8 0.4 0.5 1.6 0.2 0.2 3.3 2.0 0.1 0.1 0.2 0.0 0.1 0.1 0.1 0.1 0.0 0.3 0.2 0.2 0.8 0.4 0.1 0.1 0.1 0.0 19.0 17.7 17.9 19.9 15.2 17.9 19.6 18.3 19.8 16.4 21.2 17.1 345.4 9.6 5.8 0.7 2.7 11.0 121.5 244.1 8.0 0.0 32.0 73.0 46.7 37.1 28.6 132.4 0.0 1235.1 2.6 158.9 1.9 378.7 1.4 8.4 3.2 161.4 11.4 13.5 0.1 92.2 223.5 35.0 50.0 14.4 14.7 49.7 306.6 4.4 89.3 0.0 1.1 35.5 14.2 8.8 10.3 0.7 7.5 4.2 23.2 13.1 2.0 0.2 0.0 0.5 0.0 344.6 115.3 4.1 0.2 131.4 45.2 80.9 9.1 0.4 427.3 9.5 357.4 0.3 0.8 4.9 6.5 1946.1 3.8 2.7 59.7 219.4 TNFAIP3 "A20, OTUD7C" ENSG00000118503 "TNF alpha induced protein 3" P21580 6 137867214-137883312 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Inflammatory response, Ubl conjugation pathway" "DNA-binding, Hydrolase, Multifunctional enzyme, Protease, Thiol protease, Transferase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 519.5" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 774.9;Endometrial ciliated cells: 605.2;Glandular and luminal cells: 1498.3;Macrophages: 596.6;Suprabasal keratinocytes: 745.7;T-cells: 624.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "GAMG: 106.5;Karpas-707: 161.3;REH: 151.5;U-266/84: 131.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002116 Approved Approved Centrosome,Cytosol NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 2: Karpas-707 - Immune response" "Cluster 41: Macrophages - Immune response" "Centrosome, Cytosol" "HPA002116: AB_1858162" "unprognostic (5.50e-3)" "unprognostic (9.98e-3)" "unprognostic (3.06e-2)" "unprognostic (1.01e-2)" "unprognostic (4.01e-2)" "unprognostic (9.47e-2)" "unprognostic (5.01e-3)" "unprognostic (4.40e-2)" "unprognostic (2.92e-2)" "unprognostic (2.58e-1)" "unprognostic (1.72e-1)" "unprognostic (2.06e-1)" "prognostic unfavorable (6.05e-4)" "unprognostic (6.06e-2)" "unprognostic (3.55e-3)" "unprognostic (1.27e-1)" "unprognostic (6.29e-2)" 57.0 15.6 4.4 114.6 3.8 519.5 23.3 2.9 23.9 27.5 12.0 22.6 21.4 31.3 5.2 26.6 23.4 47.8 23.0 3.2 2.8 13.8 27.4 56.2 76.8 6.1 3.9 73.2 25.8 25.8 7.5 28.9 6.7 17.3 24.7 19.1 16.1 10.3 8.6 50.5 30.7 33.5 6.6 46.1 22.8 8.3 9.5 71.1 11.7 3.8 55.7 171.1 14.6 6.2 32.6 4.8 1.8 2.8 10.1 16.9 7.8 18.8 67.6 4.8 5.7 34.9 8.8 7.3 43.1 20.0 106.5 22.6 1.1 50.4 8.9 46.8 2.2 7.5 19.8 21.1 11.2 10.3 12.8 15.6 7.3 56.4 53.6 5.6 2.9 21.2 17.4 161.3 8.4 1.8 56.2 41.4 1.5 2.1 1.4 151.5 39.4 6.1 14.8 15.1 0.7 0.3 3.6 5.3 16.9 7.0 3.4 11.7 14.8 46.9 6.8 46.0 9.6 48.7 131.4 14.0 16.9 13.1 6.1 7.3 12.6 9.6 19.6 9.3 27.9 7.4 19.4 18.0 14.3 7.8 13.1 10.1 13.6 11.1 5.1 26.2 19.2 14.8 4.4 3.8 2.9 23.9 3.2 2.8 6.1 3.9 6.7 6.6 9.5 6.2 71.8 38.5 76.3 2.0 94.5 774.9 150.2 102.1 384.7 1.1 29.0 42.3 4.6 25.8 53.7 0.0 29.2 8.1 395.5 53.9 1.9 60.0 2.6 605.2 365.9 114.8 11.9 5.2 0.1 26.9 104.8 110.1 111.1 1498.3 255.9 2.3 48.5 13.5 45.7 0.0 0.3 38.6 67.1 125.2 461.8 3.2 6.8 596.6 129.9 8.4 59.1 1.7 14.4 2.0 0.3 30.5 29.5 6.0 331.4 170.2 37.3 3.1 84.3 13.3 6.6 29.0 94.9 2.7 2.2 367.9 745.7 23.1 624.2 14.9 20.9 78.1 UCHL1 "PARK5, PGP9.5, Uch-L1" ENSG00000154277 "Ubiquitin C-terminal hydrolase L1" P09936 4 41256413-41268455 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 692.7;pituitary gland: 285.4" "Cell type enhanced" "Detected in many" "Collecting duct cells: 115.8;Distal tubular cells: 258.2;Excitatory neurons: 147.1;Horizontal cells: 146.4;Inhibitory neurons: 118.4;Spermatogonia: 88.4" "Cancer enhanced" "Detected in all" "glioma: 129.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "EFO-21: 1142.2;SCLC-21H: 1160.6;U-251 MG: 1162.6;U-266/84: 1138.4;U-87 MG: 1209.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002580, HPA005993, CAB079024" Enhanced Supported Supported Nucleoplasm,Cytosol NA NA 500000 "Cluster 43: B-cells - Humoral immune response" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 39: Non-specific - Basic cellular processes" Cytosol Nucleoplasm "CAB002580: AB_563981, CAB079024: , HPA005993: AB_1858560" "unprognostic (1.54e-1)" "unprognostic (1.96e-1)" "unprognostic (1.12e-1)" "prognostic unfavorable (4.08e-5)" "unprognostic (2.34e-1)" "unprognostic (1.98e-1)" "unprognostic (6.28e-3)" "unprognostic (1.09e-2)" "unprognostic (4.31e-2)" "unprognostic (8.77e-3)" "unprognostic (3.56e-3)" "unprognostic (3.70e-2)" "unprognostic (1.82e-3)" "unprognostic (1.24e-2)" "unprognostic (7.12e-3)" "unprognostic (2.10e-2)" "prognostic unfavorable (1.93e-4)" 30.1 104.4 211.4 19.2 188.8 0.6 13.6 83.4 342.7 18.9 0.0 49.0 9.0 13.2 3.3 3.3 9.7 12.3 26.9 229.7 692.7 62.7 1.6 8.2 12.9 255.7 205.2 35.6 11.6 0.6 285.4 2.5 446.7 12.3 6.9 38.3 3.7 5.8 27.5 4.7 18.9 9.2 122.2 2.7 14.5 16.5 150.3 4.1 9.8 7.7 7.3 31.7 29.1 231.2 3.3 712.8 146.8 0.4 18.9 19.7 0.4 681.4 352.8 236.0 243.4 149.0 0.9 0.0 1142.2 384.4 356.7 1.1 262.8 0.6 116.4 1.5 97.0 0.0 6.9 0.2 529.3 0.1 1.2 127.4 3.0 197.9 0.0 413.7 2.0 0.0 0.0 2.3 122.6 0.6 1.0 12.3 435.3 0.0 714.1 0.1 297.2 0.7 386.3 0.3 1160.6 765.7 5.1 2.8 1.8 165.4 0.8 5.0 3.3 16.8 5.2 0.4 1162.6 583.1 1138.4 3.1 1209.3 1.1 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 211.4 188.8 83.4 342.7 229.7 692.7 255.7 205.2 446.7 122.2 150.3 231.2 0.8 0.0 3.1 29.0 2.1 1.7 1.1 1.5 1.2 25.6 0.3 0.6 3.1 0.0 3.5 115.8 8.4 3.6 0.0 0.1 258.2 4.3 3.5 0.9 9.8 3.9 4.2 0.8 147.1 0.8 0.8 35.4 1.1 0.5 2.5 46.3 8.9 0.6 4.7 146.4 118.4 0.0 4.1 0.6 3.4 6.0 37.0 2.3 3.6 35.6 0.6 21.6 0.0 55.8 54.6 3.0 0.0 17.3 9.2 3.7 0.0 17.1 7.4 61.3 0.0 3.6 35.7 10.4 88.4 0.3 1.6 1.5 1.3 20.0 0.2 1.0 UCHL3 ENSG00000118939 "Ubiquitin C-terminal hydrolase L3" P15374 13 75549480-75606020 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019678, CAB037139, CAB037208" Approved Supported Nucleoplasm,Cytosol No No 700000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Cytosol" "CAB037139: AB_1841234, CAB037208: AB_1841235, HPA019678: AB_1858583" "unprognostic (4.16e-1)" "unprognostic (3.84e-2)" "unprognostic (8.83e-3)" "unprognostic (1.14e-1)" "unprognostic (5.15e-2)" "unprognostic (6.46e-3)" "prognostic unfavorable (6.41e-4)" "unprognostic (1.19e-1)" "unprognostic (5.59e-2)" "unprognostic (9.71e-2)" "unprognostic (1.24e-1)" "unprognostic (7.09e-2)" "unprognostic (4.47e-2)" "unprognostic (3.97e-1)" "unprognostic (2.76e-2)" "unprognostic (8.84e-2)" "unprognostic (3.26e-2)" 20.7 56.9 20.6 20.2 24.2 33.5 34.2 20.3 25.2 15.3 17.2 35.4 21.6 12.4 63.2 58.0 13.0 17.7 29.3 21.7 20.5 32.2 50.9 15.0 21.3 18.6 18.9 7.4 30.9 23.9 22.9 24.6 18.5 19.5 39.5 9.7 27.2 18.2 53.9 48.6 19.9 25.1 18.9 15.9 25.1 43.3 20.5 25.7 44.4 40.6 34.6 44.3 26.6 21.0 196.0 31.9 26.9 18.8 49.9 58.6 78.6 72.3 70.3 90.7 100.5 177.5 92.1 100.4 50.2 75.7 70.2 105.8 64.1 175.3 137.1 53.8 55.9 62.2 50.7 114.9 71.6 150.4 45.7 52.6 118.7 71.7 114.2 38.4 90.1 79.6 70.0 27.9 138.9 70.2 62.4 100.2 40.3 229.0 95.1 49.5 42.9 66.3 108.4 77.9 81.0 23.8 40.8 78.3 34.5 58.2 45.7 42.0 70.8 39.6 47.9 42.7 98.2 39.5 45.5 117.1 80.4 161.3 29.0 57.6 68.7 49.3 29.9 134.4 39.6 51.5 54.1 43.0 99.5 51.5 53.0 49.5 15.6 62.7 117.9 134.9 71.8 50.1 20.6 24.2 20.3 25.2 21.7 20.5 18.6 18.9 18.5 18.9 20.5 21.0 18.2 9.6 23.4 9.1 20.3 76.3 80.4 197.5 35.9 9.3 48.8 66.2 27.2 28.6 88.2 46.0 2.1 105.2 32.9 39.0 92.0 146.2 198.2 35.4 17.4 26.6 24.0 24.4 22.5 143.1 163.6 25.1 23.9 36.2 24.1 19.3 13.9 45.7 88.0 16.8 22.3 54.6 81.4 28.8 28.8 43.5 16.8 32.8 26.6 18.7 33.3 17.3 22.6 22.6 24.9 153.1 44.3 11.7 33.3 133.1 40.4 119.6 48.0 8.9 19.7 24.5 73.5 159.3 36.8 64.8 79.1 169.0 22.1 47.6 60.8 96.2 UCHL5 "CGI-70, INO80R, UCH37" ENSG00000116750 "Ubiquitin C-terminal hydrolase L5" Q9Y5K5 1 193012250-193060080 "Enzymes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005908, HPA006069" Approved Supported Nucleoplasm,Nucleoli,Cytosol NA NA 18000 "Cluster 44: Non-specific - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 1: K-562 - Erythropoiesis" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Cytosol" Nucleoli "HPA005908: AB_1858585, HPA006069: " "unprognostic (3.66e-2)" "unprognostic (3.84e-3)" "unprognostic (5.17e-2)" "unprognostic (5.98e-2)" "unprognostic (1.20e-2)" "unprognostic (1.20e-1)" "unprognostic (3.50e-2)" "unprognostic (7.41e-2)" "unprognostic (1.96e-2)" "unprognostic (1.04e-3)" "unprognostic (3.44e-3)" "unprognostic (6.92e-2)" "unprognostic (6.41e-3)" "unprognostic (1.51e-1)" "unprognostic (7.15e-2)" "prognostic unfavorable (7.10e-5)" "unprognostic (4.33e-2)" 19.9 19.0 11.0 22.5 12.1 24.6 22.7 20.3 15.8 13.6 5.5 23.3 24.7 14.8 17.5 32.2 11.3 15.5 30.5 13.3 12.3 27.2 37.9 15.9 29.1 11.8 11.5 16.4 33.1 20.3 9.7 23.1 12.8 21.4 24.0 37.7 26.0 16.0 39.7 21.3 24.2 18.1 12.9 18.0 17.8 13.4 10.7 24.8 19.2 36.8 32.6 19.1 14.3 14.1 136.6 74.0 61.7 65.5 37.1 37.8 76.4 80.1 40.4 74.8 65.8 71.4 94.9 104.7 72.5 44.4 43.2 85.5 84.1 99.5 100.9 110.0 61.9 126.0 97.5 97.3 57.6 198.5 67.8 33.9 44.5 106.1 91.2 33.6 76.4 100.3 285.1 86.2 67.3 105.9 146.2 70.1 57.7 89.1 46.9 84.5 68.3 216.4 70.8 81.0 61.2 76.7 72.7 97.3 110.4 64.9 82.2 95.8 49.9 71.9 21.4 70.0 125.0 62.8 105.2 117.5 40.2 119.5 123.6 60.9 31.7 41.6 53.3 40.1 59.5 43.8 48.0 51.2 39.0 37.4 51.0 57.1 19.5 75.2 45.0 41.3 51.3 44.8 11.0 12.1 20.3 15.8 13.3 12.3 11.8 11.5 12.8 12.9 10.7 14.1 33.9 9.6 30.2 12.7 28.6 24.3 13.5 27.9 18.8 20.6 19.4 16.6 79.5 21.5 28.5 27.6 43.8 35.8 45.7 18.9 45.0 26.3 2.8 13.0 15.4 21.4 10.8 39.7 35.4 28.3 34.5 22.8 20.9 16.0 56.3 21.4 17.9 24.6 28.0 25.2 33.2 20.2 16.2 18.8 20.7 3.8 14.9 25.0 17.8 19.7 23.4 27.4 75.2 18.1 29.6 25.3 10.6 17.3 58.5 21.8 30.2 39.9 21.1 43.5 19.7 19.6 34.9 22.1 16.8 32.7 30.0 25.2 34.5 31.9 23.2 12.4 UFSP1 UFSP ENSG00000176125 "UFM1 specific peptidase 1 (inactive)" Q6NVU6 7 100888721-100889715 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal tubular cells: 7.9;Proximal tubular cells: 7.4;Sertoli cells: 6.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027099 Uncertain NA NA "Cluster 24: B-cells - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA027099: AB_2214069" "unprognostic (8.56e-2)" "unprognostic (2.62e-2)" "unprognostic (2.23e-1)" "unprognostic (1.94e-1)" "unprognostic (7.21e-3)" "unprognostic (1.18e-1)" "unprognostic (2.62e-1)" "unprognostic (1.51e-2)" "unprognostic (2.14e-1)" "unprognostic (2.11e-1)" "unprognostic (3.55e-3)" "unprognostic (5.71e-2)" "unprognostic (4.40e-2)" "unprognostic (1.77e-1)" "unprognostic (2.48e-1)" "unprognostic (2.46e-1)" "unprognostic (3.09e-2)" 2.0 2.7 1.2 0.9 1.3 0.6 1.6 1.9 1.7 1.5 0.2 1.8 1.0 2.4 1.3 1.9 1.8 0.1 1.6 0.9 1.2 2.1 3.1 1.0 0.6 1.4 1.5 0.9 3.1 1.0 2.3 0.4 1.4 1.8 0.5 0.3 1.7 1.0 3.7 1.1 1.5 0.8 1.2 1.6 1.9 0.7 1.1 0.8 1.4 1.2 0.4 2.1 1.1 1.5 2.9 3.7 0.8 3.8 3.6 2.1 2.3 2.2 0.7 0.9 0.6 1.5 2.0 0.7 1.7 1.8 1.4 5.6 1.1 1.3 0.5 2.6 8.2 2.4 3.2 1.8 3.6 1.0 1.1 2.4 1.6 1.2 4.6 1.0 0.3 1.4 3.7 1.7 1.4 7.3 2.4 6.0 2.8 3.0 5.1 1.2 1.1 5.8 1.6 1.3 2.6 4.3 4.4 5.6 2.7 1.1 1.4 0.9 0.9 2.4 2.5 2.6 1.7 1.7 2.2 0.2 0.8 2.0 2.8 0.0 2.4 1.5 3.1 2.1 3.5 1.0 2.6 1.7 2.9 3.9 2.9 3.6 0.4 3.0 2.2 4.4 1.2 1.7 1.2 1.3 1.9 1.7 0.9 1.2 1.4 1.5 1.4 1.2 1.1 1.5 0.7 0.0 0.0 0.0 0.8 0.6 2.3 1.3 1.8 0.4 1.4 1.3 0.8 1.5 0.7 1.8 0.0 2.4 0.8 2.5 7.9 2.2 0.3 2.2 3.6 0.8 3.0 0.8 0.3 2.1 1.2 1.2 1.1 1.2 0.0 0.6 1.8 4.7 1.9 0.0 0.3 2.2 0.0 0.8 0.7 0.4 1.8 0.6 0.0 1.0 0.5 2.5 0.0 1.0 0.2 1.8 5.0 1.9 1.3 3.2 1.6 7.4 0.7 1.0 6.6 1.5 1.5 0.2 0.3 2.4 1.0 1.6 0.8 4.4 2.5 2.2 UFSP2 "C4orf20, FLJ11200" ENSG00000109775 "UFM1 specific peptidase 2" Q9NUQ7 4 185399537-185425979 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 190.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039985, HPA043298" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 44: Non-specific - Transcription" "Cluster 54: Non-specific - Microtubule organization" "Cluster 30: Epithelial cell lines - Translation" "Cluster 66: Spermatocytes - Spermatogenesis" "Nucleoplasm, Cytosol" "HPA039985: AB_10794206, HPA043298: AB_10795037" "unprognostic (8.87e-2)" "unprognostic (1.85e-2)" "unprognostic (1.52e-1)" "unprognostic (1.97e-1)" "unprognostic (1.17e-1)" "unprognostic (1.29e-1)" "unprognostic (3.63e-2)" "unprognostic (3.19e-2)" "unprognostic (3.69e-1)" "unprognostic (1.50e-1)" "unprognostic (2.04e-2)" "unprognostic (2.56e-1)" "prognostic favorable (1.07e-8)" "unprognostic (1.92e-1)" "unprognostic (8.12e-2)" "unprognostic (9.36e-3)" "unprognostic (6.70e-3)" 21.2 24.9 19.9 9.5 21.7 5.7 24.3 25.2 24.1 21.6 29.6 19.5 13.0 19.9 28.1 25.8 17.7 15.6 32.1 20.4 21.9 37.3 24.1 17.1 11.9 20.4 20.2 31.4 19.7 23.8 10.0 14.0 20.9 19.8 15.3 56.4 20.3 19.2 48.5 21.6 12.0 20.2 20.7 14.5 17.5 21.0 21.3 14.3 25.9 40.6 16.1 16.2 10.1 25.3 17.5 11.9 28.8 24.3 25.8 25.6 15.3 20.3 20.5 19.3 19.3 18.4 23.2 17.9 9.0 19.7 14.7 16.1 20.4 32.2 17.4 21.8 12.4 11.8 13.0 23.3 30.2 15.3 12.3 14.7 26.8 16.5 16.7 26.7 35.7 21.9 24.8 34.3 28.2 16.3 22.0 16.4 8.7 11.8 16.7 20.2 11.5 20.4 31.9 11.4 18.6 14.8 11.3 25.6 23.1 17.6 15.4 13.6 27.3 9.5 16.8 7.5 17.2 34.6 14.8 9.5 30.5 11.0 25.3 10.8 12.3 7.6 21.2 10.4 25.7 22.0 21.7 24.1 14.1 15.4 23.2 22.9 0.7 21.5 11.1 19.9 20.6 12.5 19.9 21.7 25.2 24.1 20.4 21.9 20.4 20.2 20.9 20.7 21.3 25.3 33.8 6.4 23.9 14.7 30.1 22.0 28.7 35.1 33.0 47.6 20.9 25.5 27.0 15.7 31.1 20.2 66.7 26.0 23.4 8.3 111.6 28.3 190.5 16.4 28.9 24.1 19.3 24.0 12.2 33.1 29.7 34.2 20.4 19.2 29.7 21.9 21.8 17.3 27.2 18.5 17.8 18.6 28.5 22.1 18.8 52.9 35.4 18.5 35.6 12.2 17.3 71.8 21.6 23.6 33.2 19.7 14.6 42.2 53.0 15.4 22.2 100.9 23.7 87.9 65.7 31.8 38.9 89.3 56.7 22.6 18.9 41.9 27.1 35.6 14.8 19.6 USP1 ENSG00000162607 "Ubiquitin specific peptidase 1" O94782 1 62436297-62451804 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 302.7;Spermatogonia: 206.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028387, HPA028440" Approved Supported Nucleoplasm NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "HPA028387: AB_2672578, HPA028440: AB_10603000" "unprognostic (1.22e-1)" "unprognostic (5.36e-2)" "unprognostic (1.78e-3)" "unprognostic (4.05e-3)" "unprognostic (2.57e-1)" "unprognostic (1.72e-2)" "prognostic unfavorable (5.81e-5)" "unprognostic (6.72e-2)" "unprognostic (1.11e-2)" "unprognostic (5.32e-2)" "unprognostic (3.33e-3)" "unprognostic (3.99e-2)" "unprognostic (2.76e-2)" "unprognostic (9.61e-3)" "unprognostic (5.70e-2)" "unprognostic (1.96e-1)" "unprognostic (1.71e-1)" 13.8 10.6 12.4 21.0 14.7 53.2 23.9 20.2 15.4 16.2 11.8 19.0 17.1 20.7 16.8 17.9 16.7 11.9 12.2 11.5 13.4 14.1 13.5 16.0 32.3 12.8 13.0 26.0 16.0 18.2 10.0 14.4 13.7 16.7 20.7 34.5 14.7 15.9 11.9 19.3 17.2 17.0 14.2 19.4 16.9 51.5 12.9 48.1 20.2 16.0 31.7 13.9 11.9 17.3 85.6 25.5 96.8 53.2 21.3 25.5 57.0 79.7 52.1 93.3 101.2 41.4 39.3 151.3 57.0 43.1 83.6 48.0 80.3 53.0 128.5 79.5 63.5 124.5 82.1 42.7 23.2 132.5 60.9 13.7 33.8 84.1 62.8 25.1 44.9 100.1 92.7 125.3 66.2 38.0 136.9 50.9 88.2 48.5 52.4 131.9 166.3 93.9 34.9 60.1 103.4 58.6 89.3 70.1 86.8 64.2 41.3 79.7 32.1 72.7 80.7 109.3 112.9 52.2 78.1 171.1 49.5 104.0 67.0 22.6 9.9 26.0 12.7 10.5 16.9 15.6 15.3 13.5 12.3 11.2 14.4 12.2 17.4 17.9 14.9 12.4 15.3 10.3 12.4 14.7 20.2 15.4 11.5 13.4 12.8 13.0 13.7 14.2 12.9 17.3 35.8 48.1 31.8 6.2 58.7 62.2 34.7 32.9 75.7 49.6 41.5 46.2 34.9 24.3 34.9 16.5 22.9 43.7 52.4 22.7 19.6 34.1 173.9 37.2 32.3 39.7 8.4 85.2 10.3 34.1 59.2 43.9 15.8 33.2 27.8 41.4 30.0 18.4 31.0 35.3 11.2 33.3 30.5 27.2 38.8 81.1 50.1 34.7 26.6 7.5 56.0 49.5 62.8 10.6 17.2 27.5 12.7 41.0 63.7 56.8 22.7 17.3 41.9 86.6 52.6 59.7 42.0 302.7 206.7 73.8 64.4 33.0 59.7 21.2 39.5 35.8 USP10 "KIAA0190, UBPO" ENSG00000103194 "Ubiquitin specific peptidase 10" Q14694 16 84699986-84779922 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Autophagy, DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 5 "neutrophil: 742.4" "Lineage enriched" "Detected in all" 5 "granulocytes: 742.4" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006731, HPA006749" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Cytosol Nucleoplasm "HPA006731: AB_1080495, HPA006749: AB_1080492" "unprognostic (4.14e-2)" "unprognostic (2.28e-1)" "unprognostic (2.36e-2)" "unprognostic (4.85e-2)" "unprognostic (6.93e-2)" "unprognostic (1.77e-3)" "unprognostic (1.03e-3)" "unprognostic (2.91e-3)" "unprognostic (1.75e-1)" "unprognostic (3.84e-2)" "unprognostic (2.56e-2)" "unprognostic (1.82e-3)" "prognostic favorable (1.00e-4)" "unprognostic (5.91e-2)" "unprognostic (4.57e-2)" "unprognostic (8.57e-2)" "unprognostic (1.38e-1)" 24.8 21.7 19.6 29.4 20.3 29.5 23.4 22.1 22.9 21.0 17.8 31.2 29.5 25.9 23.9 29.1 27.0 18.5 25.4 20.8 20.7 28.8 33.8 18.7 36.7 18.8 18.7 27.1 23.0 41.5 6.0 40.3 19.0 28.3 26.4 52.5 21.0 25.9 46.6 25.7 27.4 31.0 19.8 32.6 23.8 22.0 20.4 29.1 27.4 39.5 37.7 32.1 10.1 21.6 63.6 72.9 78.5 104.7 31.4 50.2 111.5 58.0 60.1 96.9 51.5 106.9 54.9 102.9 65.2 61.1 47.7 69.8 108.2 89.7 139.0 41.3 63.3 63.2 37.3 92.2 39.4 95.0 37.9 30.0 74.8 95.6 112.3 57.5 76.4 68.5 153.4 22.7 73.1 129.4 92.4 96.8 102.5 71.8 56.7 119.9 44.5 55.0 81.9 48.4 73.0 48.6 130.5 48.7 54.0 72.3 108.4 76.8 55.7 66.9 60.2 39.4 62.2 38.8 53.7 272.3 44.5 64.6 73.2 29.0 77.3 15.6 46.1 61.9 58.0 60.6 148.0 53.9 92.6 59.7 82.9 49.6 742.4 65.9 58.6 30.7 57.3 97.3 19.6 20.3 22.1 22.9 20.8 20.7 18.8 18.7 19.0 19.8 20.4 21.6 21.3 54.5 50.0 26.4 51.5 51.5 46.1 25.8 54.1 25.1 27.6 28.6 66.6 25.8 45.2 27.6 29.2 106.9 38.1 25.8 31.3 29.0 63.3 31.0 35.8 30.4 28.9 42.5 39.3 25.1 73.4 40.1 35.7 42.1 58.0 38.7 21.0 37.2 31.4 20.2 38.9 28.1 16.2 34.8 33.4 116.6 23.6 40.6 24.9 41.2 52.6 23.7 32.0 49.8 35.8 23.6 23.9 22.6 50.8 48.6 30.4 45.0 90.7 52.7 26.3 58.4 34.3 35.0 29.5 54.5 49.6 60.9 42.5 33.6 40.6 45.2 USP11 UHX1 ENSG00000102226 "Ubiquitin specific peptidase 11" P51784 X 47232866-47248328 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Bipolar cells: 203.6;Horizontal cells: 139.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003103, HPA037536" Enhanced Supported Supported Nucleoplasm,Cytosol "Intracellular and membrane" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 56: Bipolar cells - Visual perception" Nucleoplasm Cytosol "HPA003103: AB_10671088, HPA037536: AB_10672904" "unprognostic (1.60e-1)" "unprognostic (2.77e-3)" "unprognostic (5.84e-2)" "prognostic unfavorable (2.95e-4)" "unprognostic (3.08e-2)" "unprognostic (2.02e-1)" "unprognostic (6.11e-3)" "unprognostic (9.21e-2)" "unprognostic (3.18e-2)" "unprognostic (3.52e-1)" "unprognostic (3.29e-3)" "unprognostic (3.74e-2)" "prognostic favorable (4.13e-5)" "unprognostic (3.14e-2)" "unprognostic (9.23e-2)" "unprognostic (9.51e-2)" "unprognostic (7.11e-2)" 25.5 32.8 117.7 23.7 118.7 11.2 26.8 41.5 116.3 51.2 30.0 33.9 11.5 47.0 23.6 18.2 49.9 24.5 45.5 113.1 148.1 33.3 12.7 30.9 30.1 69.8 78.3 76.4 27.1 36.6 103.7 24.9 93.9 33.4 14.1 84.8 21.4 38.7 32.4 18.5 25.5 35.9 65.4 29.3 24.9 46.2 122.8 42.6 52.2 29.6 28.9 36.9 31.7 79.8 45.6 70.7 117.6 81.0 43.4 28.5 33.0 34.0 52.5 65.6 73.3 67.4 36.7 29.9 26.1 60.5 70.5 53.5 94.7 24.0 56.4 47.1 73.5 34.7 52.9 61.4 50.7 39.2 70.7 42.1 9.8 69.1 29.3 37.3 26.7 68.9 26.6 3.9 51.8 70.0 77.8 43.4 89.2 24.3 62.5 86.1 114.3 25.1 32.4 60.9 66.8 114.4 62.6 12.4 37.7 73.9 26.0 23.0 28.2 56.0 58.0 79.3 39.6 54.3 36.2 51.3 34.3 48.8 50.8 63.9 9.1 19.9 55.4 19.6 48.3 53.1 24.5 54.3 11.9 53.1 36.6 76.3 5.5 56.4 24.3 53.2 35.0 46.0 117.7 118.7 41.5 116.3 113.1 148.1 69.8 78.3 93.9 65.4 122.8 79.8 13.6 22.4 17.7 25.8 53.5 13.6 42.2 30.9 21.6 203.6 13.0 23.5 24.2 7.2 31.5 33.1 56.3 20.9 52.2 9.4 50.9 18.3 26.4 28.2 26.3 22.5 35.4 18.3 43.3 10.2 15.0 41.3 22.4 28.3 45.7 56.6 22.1 8.2 13.4 139.7 63.7 8.7 28.5 12.0 16.3 41.0 29.5 17.9 28.4 19.7 17.5 96.2 23.7 25.1 24.8 12.5 7.9 42.2 48.1 18.6 4.7 15.2 46.4 63.4 26.3 57.2 40.2 18.3 87.8 11.9 6.5 16.3 44.6 34.2 8.9 26.0 USP12 USP12L1 ENSG00000152484 "Ubiquitin specific peptidase 12" O75317 13 27066156-27171811 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Langerhans cells: 153.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007288, HPA059492" Uncertain Approved Nucleoplasm NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 41: Macrophages - Immune response" Nucleoplasm "HPA007288: AB_1080531, HPA059492: " "unprognostic (6.72e-3)" "unprognostic (2.63e-3)" "unprognostic (1.04e-1)" "unprognostic (2.34e-2)" "unprognostic (1.22e-1)" "unprognostic (5.85e-2)" "unprognostic (1.79e-1)" "unprognostic (3.39e-1)" "unprognostic (8.38e-2)" "unprognostic (8.77e-2)" "unprognostic (2.20e-1)" "unprognostic (3.06e-2)" "unprognostic (1.22e-2)" "unprognostic (1.40e-1)" "unprognostic (2.91e-1)" "unprognostic (6.77e-2)" "unprognostic (1.73e-1)" 20.4 13.6 21.0 20.9 22.0 75.7 15.3 21.6 26.7 13.1 15.5 35.6 18.2 13.2 15.1 17.0 13.5 17.9 14.4 23.7 22.2 24.8 34.9 23.6 29.4 18.9 24.8 14.7 15.3 16.5 13.8 17.7 19.5 14.0 25.5 38.0 10.2 12.1 13.1 24.0 24.3 18.6 21.0 17.2 17.7 15.5 22.2 12.2 16.1 15.9 26.4 21.8 13.5 21.8 24.9 15.3 28.6 14.9 18.8 23.8 10.2 34.1 23.9 18.5 13.7 27.7 37.8 35.1 16.6 27.0 44.9 15.0 18.9 19.8 39.4 57.0 16.1 54.3 19.2 19.6 23.6 31.8 36.5 14.9 28.3 21.0 23.9 23.4 43.3 23.8 18.4 16.5 38.9 14.4 19.6 42.0 20.5 31.5 26.7 22.1 36.5 8.3 36.3 17.3 31.5 19.0 29.3 24.2 28.2 35.5 11.4 30.4 51.6 19.3 18.6 41.6 31.4 12.6 15.0 24.6 32.4 18.5 22.0 0.0 0.5 2.2 0.5 0.5 0.9 1.2 0.9 0.8 0.6 1.6 0.6 0.6 0.5 0.9 0.8 1.1 1.4 0.4 21.0 22.0 21.6 26.7 23.7 22.2 18.9 24.8 19.5 21.0 22.2 21.8 54.2 28.9 29.9 19.6 42.1 91.6 29.4 7.0 34.7 23.8 30.6 24.0 23.4 17.2 9.1 23.9 39.6 15.4 26.5 47.0 29.4 12.8 19.2 29.1 26.4 42.0 20.9 60.6 37.0 16.3 7.0 34.2 23.9 68.9 13.3 15.7 21.4 23.3 14.0 28.6 29.0 27.5 10.2 20.8 153.8 10.7 7.8 47.8 39.2 42.2 33.6 13.8 9.2 43.7 65.0 24.4 37.4 6.4 37.1 34.0 34.3 21.3 12.2 32.1 32.9 114.7 42.8 2.7 12.9 23.1 79.0 10.9 27.2 9.3 24.1 40.6 USP13 IsoT-3 ENSG00000058056 "Ubiquitin specific peptidase 13" Q92995 3 179653032-179804366 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Autophagy, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 149.2;tongue: 108.9" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 208.5;Inhibitory neurons: 52.2;Theca cells: 58.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "MAIT T-cell: 15.6" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "HDLM-2: 93.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004827 Enhanced Approved Nucleoplasm,Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 54: Cardiomyocytes - Muscle contraction" "Nucleoplasm, Cytosol" "HPA004827: AB_1080497" "unprognostic (1.00e-2)" "unprognostic (2.09e-1)" "unprognostic (5.82e-2)" "unprognostic (7.14e-2)" "unprognostic (9.94e-2)" "unprognostic (3.96e-2)" "prognostic unfavorable (2.40e-5)" "unprognostic (1.76e-1)" "unprognostic (4.55e-2)" "unprognostic (7.79e-2)" "unprognostic (1.69e-3)" "unprognostic (2.22e-2)" "prognostic unfavorable (3.46e-6)" "unprognostic (4.93e-2)" "unprognostic (9.79e-2)" "unprognostic (3.38e-2)" "prognostic unfavorable (3.06e-4)" 6.2 11.9 3.9 2.8 13.6 1.5 5.3 8.6 12.0 3.3 0.0 2.9 1.2 5.7 3.4 4.0 3.4 4.5 42.5 3.7 4.7 3.0 4.6 5.4 3.6 11.3 10.5 12.5 4.1 4.0 5.8 2.6 12.7 4.3 2.2 7.1 6.2 2.7 149.2 2.2 1.9 6.3 6.4 2.1 1.7 6.0 8.1 2.4 9.7 108.9 3.5 3.5 2.2 34.4 27.6 11.3 20.0 14.8 8.9 14.1 11.6 18.6 17.4 23.7 18.8 17.1 9.6 35.6 18.0 17.2 27.6 2.6 21.4 9.1 26.4 93.3 14.8 9.0 23.6 14.4 6.3 26.5 1.1 10.5 3.0 18.8 18.5 9.1 16.6 11.9 4.7 43.0 15.7 15.0 22.5 3.0 17.9 1.3 13.1 29.3 20.2 27.4 11.7 7.9 13.0 14.5 14.1 16.9 7.2 5.4 37.0 12.7 24.1 28.6 27.6 23.7 64.1 29.5 21.2 78.3 13.0 15.0 27.2 0.1 0.3 0.0 2.6 0.5 15.6 3.2 1.8 3.8 1.5 0.9 1.2 1.3 0.0 0.0 0.7 4.5 0.7 1.3 3.9 13.6 8.6 12.0 3.7 4.7 11.3 10.5 12.7 6.4 8.1 34.4 45.0 9.6 35.9 14.0 5.3 2.5 1.9 1.4 0.6 13.7 7.1 5.2 208.5 5.7 5.4 1.8 6.2 10.7 5.6 1.4 15.6 1.1 2.6 13.9 11.4 10.1 9.6 5.5 23.2 4.4 2.4 12.0 4.1 2.5 2.5 35.5 22.1 7.6 4.3 16.8 52.2 2.9 0.0 4.8 3.5 3.6 9.3 5.0 14.2 16.9 1.7 7.0 3.1 36.2 42.5 1.0 12.2 9.4 4.5 4.4 0.1 2.7 3.7 10.2 13.1 17.8 12.0 6.1 2.8 4.8 1.6 5.1 4.1 58.8 4.5 1.4 USP14 TGT ENSG00000101557 "Ubiquitin specific peptidase 14" P54578 18 158383-214629 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Immunity, Innate immunity, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001308 Approved Supported "Plasma membrane,Cytosol" NA NA 2700000 "Cluster 15: NK-cells - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" "Plasma membrane, Cytosol" "HPA001308: AB_1080499" "unprognostic (2.21e-1)" "unprognostic (4.05e-2)" "unprognostic (1.90e-1)" "unprognostic (2.59e-3)" "unprognostic (6.04e-2)" "prognostic unfavorable (7.81e-5)" "prognostic unfavorable (4.30e-5)" "unprognostic (5.14e-2)" "unprognostic (5.00e-2)" "prognostic favorable (7.91e-4)" "unprognostic (1.64e-2)" "unprognostic (2.39e-1)" "unprognostic (1.51e-3)" "unprognostic (2.58e-1)" "unprognostic (1.55e-1)" "unprognostic (2.20e-2)" "unprognostic (3.76e-2)" 26.0 21.5 19.9 22.7 21.3 23.9 17.0 20.1 22.9 15.5 13.9 17.8 13.9 17.0 23.8 24.0 14.6 14.6 24.8 21.0 24.5 23.4 25.3 15.1 21.6 25.4 21.7 13.3 13.0 21.2 14.3 26.5 25.7 29.7 19.3 15.5 15.2 19.6 55.6 15.4 12.4 24.7 20.3 13.8 15.1 17.9 26.0 21.8 20.4 36.4 31.3 22.6 15.3 23.3 91.6 75.4 62.7 64.5 60.7 60.0 109.6 115.5 64.9 118.9 110.5 98.9 48.7 133.1 86.6 99.1 114.4 50.9 125.1 91.7 134.9 38.7 59.0 72.5 46.0 78.1 60.5 184.1 70.8 48.4 69.1 122.3 69.5 55.0 93.5 65.9 106.2 99.3 119.1 76.2 105.2 52.4 59.4 56.0 83.5 87.8 78.6 98.0 88.7 79.9 71.8 60.1 120.7 59.2 52.5 68.0 58.2 51.5 103.9 138.7 104.3 128.8 170.6 62.3 125.7 130.9 80.0 77.3 88.4 10.7 18.1 13.8 27.9 25.8 33.6 21.1 27.5 29.5 25.6 16.4 26.7 26.2 1.5 39.3 20.5 18.7 28.6 19.4 19.9 21.3 20.1 22.9 21.0 24.5 25.4 21.7 25.7 20.3 26.0 23.3 40.0 22.4 40.4 27.7 52.7 58.6 53.3 42.0 51.8 58.0 33.4 23.5 44.9 31.5 48.3 44.1 31.3 92.3 58.1 22.5 45.0 60.6 70.9 44.9 56.3 43.1 22.1 102.0 58.8 54.0 71.8 49.0 43.8 80.8 34.8 47.1 28.2 45.4 50.9 116.1 54.4 22.5 46.8 31.5 53.4 21.6 31.7 45.5 35.6 33.7 48.8 39.4 46.4 35.2 74.8 75.8 16.9 45.9 72.7 71.4 15.2 56.0 40.2 50.3 0.0 49.6 51.4 34.1 68.1 57.9 52.4 135.6 55.0 58.9 33.5 51.8 USP15 "KIAA0529, UNPH4" ENSG00000135655 "Ubiquitin specific peptidase 15" Q9Y4E8 12 62260338-62417431 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 176.2" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 297.9" "Lineage enriched" "Detected in all" 5 "granulocytes: 297.9" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006237, HPA006428, HPA071014" Approved Supported "Nucleoplasm,Nuclear bodies,Cytosol" NA NA 300000 "Cluster 1: Neutrophils - Mixed function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 1: K-562 - Erythropoiesis" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Cytosol "Nucleoplasm, Nuclear bodies" "HPA006237: AB_1080502, HPA006428: AB_2667588, HPA071014: AB_2686333" "unprognostic (8.18e-2)" "unprognostic (3.22e-1)" "unprognostic (9.63e-2)" "unprognostic (2.09e-1)" "unprognostic (1.10e-1)" "unprognostic (2.75e-1)" "prognostic unfavorable (8.04e-4)" "unprognostic (6.59e-2)" "unprognostic (7.70e-3)" "unprognostic (2.19e-1)" "unprognostic (2.47e-1)" "unprognostic (4.51e-2)" "prognostic unfavorable (1.58e-5)" "unprognostic (9.28e-2)" "unprognostic (5.81e-3)" "unprognostic (1.11e-2)" "unprognostic (1.26e-1)" 29.0 21.6 4.5 29.4 4.8 176.2 22.9 12.3 6.7 17.6 10.2 18.0 13.8 14.6 9.2 19.7 17.8 13.7 19.8 5.2 5.5 14.9 27.2 31.5 33.3 6.0 5.4 26.7 19.7 14.9 13.9 18.4 5.7 14.3 16.7 45.8 19.7 8.3 35.5 29.9 24.6 12.6 4.6 44.3 18.8 30.2 5.5 26.5 17.1 14.8 24.9 18.1 19.4 8.0 18.3 16.5 14.2 17.7 25.7 25.1 27.0 29.0 21.2 22.3 16.1 19.6 21.6 15.5 16.6 17.8 10.1 18.5 18.4 23.1 27.6 18.5 15.0 25.2 15.1 14.1 18.8 35.6 61.8 15.0 19.2 27.2 20.7 20.7 26.1 16.3 80.8 36.0 20.0 23.5 26.4 19.3 25.4 16.5 24.0 17.2 19.1 32.3 17.9 22.8 17.9 8.9 30.9 21.6 17.3 17.4 34.7 18.8 37.2 21.2 22.2 32.0 18.2 16.4 24.0 21.9 25.7 26.7 23.5 163.4 60.0 64.3 13.5 31.1 14.9 28.5 19.6 14.0 23.7 20.5 23.5 13.8 297.9 14.7 26.8 26.6 58.8 26.1 4.5 4.8 12.3 6.7 5.2 5.5 6.0 5.4 5.7 4.6 5.5 8.0 57.1 38.5 36.4 68.6 130.3 58.8 40.8 26.2 40.5 54.9 32.3 28.1 74.9 21.5 48.9 23.9 110.5 31.7 142.5 50.2 11.7 36.4 172.2 26.3 46.5 45.4 42.0 248.3 124.8 41.5 43.3 52.5 57.6 38.9 88.6 53.5 21.0 45.3 46.2 42.1 104.2 33.2 12.2 101.3 97.6 172.0 61.8 120.6 53.4 135.9 195.8 25.6 90.6 100.0 108.8 55.1 47.6 29.3 94.3 36.0 30.9 25.9 31.9 151.5 39.5 66.1 60.5 83.7 43.3 49.3 77.0 65.8 130.0 27.0 29.5 60.8 USP16 Ubp-M ENSG00000156256 "Ubiquitin specific peptidase 16" Q9Y5T5 21 29024629-29054488 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 514.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021140 Supported Approved Nucleoplasm,Cytosol NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 23: Testis - Cell cycle regulation" "Cluster 2: Karpas-707 - Immune response" "Cluster 29: Early spermatids - Spermatogenesis" "Nucleoplasm, Cytosol" "HPA021140: AB_1858668" "unprognostic (6.06e-2)" "unprognostic (3.14e-1)" "unprognostic (1.10e-2)" "unprognostic (1.47e-1)" "unprognostic (5.92e-2)" "unprognostic (5.79e-3)" "unprognostic (1.92e-1)" "unprognostic (8.99e-2)" "unprognostic (5.78e-2)" "unprognostic (7.40e-2)" "unprognostic (8.73e-2)" "unprognostic (8.65e-2)" "unprognostic (6.68e-2)" "unprognostic (2.84e-1)" "unprognostic (1.55e-1)" "unprognostic (2.84e-2)" "unprognostic (1.54e-1)" 27.0 23.0 18.8 23.4 23.2 29.3 27.4 21.3 20.4 22.7 19.1 24.6 25.1 25.2 25.2 25.2 19.9 20.4 29.3 17.5 20.5 22.1 30.7 20.9 27.9 20.5 20.8 22.3 26.0 34.3 16.7 24.2 21.7 25.7 26.4 42.3 24.7 23.6 34.7 19.9 22.8 22.6 20.2 21.9 23.4 25.7 20.3 30.0 33.8 37.5 32.3 27.1 14.1 27.5 59.9 23.4 36.5 33.0 25.4 41.5 34.2 56.9 37.9 38.5 36.4 29.5 38.3 60.5 16.8 54.8 58.7 26.5 45.6 41.5 50.1 58.6 48.4 80.9 27.3 33.1 37.6 80.3 43.0 35.9 42.9 50.3 46.4 28.7 37.5 33.9 67.7 103.8 45.3 27.3 49.7 29.3 39.2 48.4 29.9 33.0 89.7 69.6 31.7 42.5 39.4 41.9 36.8 58.1 51.1 24.9 40.2 54.2 38.0 44.8 55.7 41.8 59.3 87.8 129.3 62.5 46.8 57.3 45.6 37.4 24.1 33.6 36.3 24.9 28.6 40.7 34.1 33.6 23.1 46.0 36.9 35.8 23.5 31.5 34.0 36.2 38.9 17.2 18.8 23.2 21.3 20.4 17.5 20.5 20.5 20.8 21.7 20.2 20.3 27.5 60.3 86.6 91.9 27.4 114.4 57.2 132.5 68.9 55.2 161.0 65.8 58.7 84.2 64.3 83.1 53.3 89.6 81.7 108.2 90.2 133.1 77.9 514.9 85.9 82.6 55.0 82.6 40.8 18.2 119.9 79.7 68.3 55.0 107.7 141.8 61.5 45.7 86.2 59.9 72.3 27.6 100.4 44.7 62.0 53.1 117.0 87.7 69.4 62.2 25.3 117.3 94.1 96.8 28.1 47.3 94.0 99.2 86.9 106.8 100.1 74.8 91.8 94.1 183.5 59.2 133.4 83.2 100.4 82.4 68.4 64.4 162.0 105.3 72.8 90.6 141.9 USP17L1 USP17L1P ENSG00000230549 "Ubiquitin specific peptidase 17 like family member 1" Q7RTZ2 8 7332387-7333979 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Evidence at transcript level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.3 0.2 0.2 0.7 0.2 0.3 0.1 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L10 ENSG00000231396 "Ubiquitin specific peptidase 17 like family member 10" C9JJH3 4 9210657-9212249 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L11 ENSG00000233136 "Ubiquitin specific peptidase 17 like family member 11" C9JVI0 4 9215405-9216997 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "Evidence at transcript level" "Tissue enriched" "Detected in single" 37 "brain: 3.6" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "Cluster 65: Brain - Ion transport" "HPA045642: AB_2679403" 0.0 0.0 3.2 0.0 1.7 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 3.4 0.0 0.0 0.0 0.0 2.4 1.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 1.7 0.0 2.4 1.4 3.4 2.4 1.0 3.6 0.2 2.3 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L12 ENSG00000227551 "Ubiquitin specific peptidase 17 like family member 12" C9JPN9 4 9220152-9221744 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L13 ENSG00000232399 "Ubiquitin specific peptidase 17 like family member 13" C9JLJ4 4 9224896-9226488 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L15 ENSG00000223569 "Ubiquitin specific peptidase 17 like family member 15" C9J2P7 4 9234385-9236046 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "Evidence at transcript level" "Tissue enriched" "Detected in single" 87 "brain: 12.3" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "Cluster 65: Brain - Ion transport" "HPA045642: AB_2679403" 0.0 0.0 7.1 0.0 3.5 0.0 0.0 0.0 7.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 6.8 3.8 0.0 0.0 0.0 0.0 10.4 0.9 0.0 0.0 0.0 0.0 0.0 12.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.9 0.0 0.0 0.0 12.2 0.0 0.0 0.0 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.1 3.5 0.0 7.6 6.8 3.8 10.4 0.9 12.3 0.9 12.2 4.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L17 ENSG00000249104 "Ubiquitin specific peptidase 17 like family member 17" D6RBQ6 4 9243879-9245471 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Evidence at transcript level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L18 ENSG00000250844 "Ubiquitin specific peptidase 17 like family member 18" D6R9N7 4 9248630-9250222 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Evidence at transcript level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L19 ENSG00000248920 "Ubiquitin specific peptidase 17 like family member 19" D6RCP7 4 9253378-9254970 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L2 DUB3 ENSG00000223443 "Ubiquitin specific peptidase 17 like family member 2" Q6R6M4 8 12137168-12139077 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" "unprognostic (2.01e-1)" 0.0 0.0 0.3 0.0 0.5 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.5 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.5 0.0 0.6 0.2 0.5 0.0 0.2 0.3 0.0 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L20 ENSG00000250745 "Ubiquitin specific peptidase 17 like family member 20" D6RJB6 4 9258124-9259716 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "Evidence at transcript level" "Tissue enriched" "Detected in single" 17 "brain: 1.7" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "Cluster 73: Brain - Neuropeptide signaling" "HPA045642: AB_2679403" 0.0 0.0 0.6 0.0 0.4 0.0 0.0 0.1 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 1.0 0.0 0.0 0.0 0.0 1.7 0.7 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.4 0.1 1.0 1.2 1.0 1.7 0.7 0.7 0.3 0.9 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L21 ENSG00000249811 "Ubiquitin specific peptidase 17 like family member 21" D6R901 4 9262872-9264464 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L22 ENSG00000248933 "Ubiquitin specific peptidase 17 like family member 22" D6RA61 4 9267619-9269211 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "Evidence at transcript level" "Tissue enriched" "Detected in single" 18 "brain: 1.8" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "Cluster 65: Brain - Ion transport" "HPA045642: AB_2679403" 0.0 0.0 1.4 0.0 0.7 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.6 0.0 0.0 0.0 0.0 1.3 0.1 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.7 0.0 1.2 0.8 0.6 1.3 0.1 1.8 0.1 1.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L23 ENSG00000250913 "Ubiquitin specific peptidase 17 like family member 23" D6RBM5 4 9272364-9272914 "Enzymes, Predicted intracellular proteins" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L24 ENSG00000232264 "Ubiquitin specific peptidase 17 like family member 24" Q0WX57 4 9325165-9326757 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L25 ENSG00000230430 "Ubiquitin specific peptidase 17 like family member 25" Q0WX57 4 9329911-9331503 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L26 ENSG00000229579 "Ubiquitin specific peptidase 17 like family member 26" Q0WX57 4 9334658-9336250 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L27 ENSG00000235780 "Ubiquitin specific peptidase 17 like family member 27" Q0WX57 4 9344148-9345740 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L28 ENSG00000231051 "Ubiquitin specific peptidase 17 like family member 28" Q0WX57 4 9348893-9350485 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L29 ENSG00000231637 "Ubiquitin specific peptidase 17 like family member 29" Q0WX57 4 9353638-9355230 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L3 "USP17B, USP17F" ENSG00000225327 "Ubiquitin specific peptidase 17 like family member 3" A6NCW0 8 7976393-7977985 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L30 ENSG00000228856 "Ubiquitin specific peptidase 17 like family member 30" Q0WX57 4 9363129-9364721 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L4 ENSG00000236125 "Ubiquitin specific peptidase 17 like family member 4" A6NCW7 8 7337115-7338707 "Enzymes, Predicted intracellular proteins" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L5 ENSG00000227140 "Ubiquitin specific peptidase 17 like family member 5" A8MUK1 4 9339403-9340995 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L7 ENSG00000226430 "Ubiquitin specific peptidase 17 like family member 7" P0C7H9 8 12132417-12134099 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" "unprognostic (5.31e-2)" 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L8 ENSG00000237038 "Ubiquitin specific peptidase 17 like family member 8" P0C7I0 8 7971661-7973253 "Enzymes, Predicted intracellular proteins" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP18 ENSG00000184979 "Ubiquitin specific peptidase 18" Q9UMW8 22 18150170-18177397 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal tubular cells: 46.9;Extravillous trophoblasts: 31.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+ SV40 Large T+: 181.8;BJ hTERT+ SV40 Large T+ RasG12V: 196.2" HPA044768 Uncertain Supported Vesicles,Cytosol NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 64: Macrophages - Immune response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 38: Extravillous trophoblasts - Unknown function" Cytosol Vesicles "HPA044768: AB_10963697" "unprognostic (2.06e-1)" "unprognostic (3.55e-2)" "unprognostic (1.57e-2)" "unprognostic (5.04e-3)" "unprognostic (1.40e-2)" "unprognostic (5.42e-2)" "unprognostic (3.29e-2)" "unprognostic (5.11e-3)" "unprognostic (1.81e-1)" "unprognostic (1.79e-3)" "unprognostic (9.77e-2)" "unprognostic (1.47e-1)" "unprognostic (4.29e-3)" "unprognostic (2.58e-1)" "unprognostic (2.77e-2)" "unprognostic (2.28e-2)" "unprognostic (8.38e-2)" 10.8 5.0 3.6 5.1 3.8 8.1 8.3 3.3 4.5 4.0 4.0 5.0 6.0 3.2 7.8 4.0 7.3 6.6 4.4 3.7 3.9 5.9 23.6 7.9 9.2 5.1 3.9 2.9 4.2 3.6 5.7 5.7 4.2 5.3 4.4 0.7 14.0 2.5 3.8 3.4 6.7 4.0 7.0 11.0 7.2 9.7 4.1 15.0 7.3 5.5 6.5 4.0 3.6 3.7 14.4 14.6 4.2 18.2 18.2 13.5 18.4 7.3 17.5 181.8 196.2 2.2 20.1 0.2 10.8 4.0 57.5 4.9 21.6 6.4 6.2 64.4 29.4 28.3 1.9 27.0 2.1 6.9 25.7 6.0 2.5 12.8 0.0 1.0 40.8 20.6 1.4 1.7 1.8 24.9 33.4 16.7 12.7 15.6 11.0 13.1 28.4 0.0 3.6 12.4 15.2 11.9 8.8 15.0 71.9 16.3 9.9 6.6 66.7 1.3 3.5 4.1 7.5 3.4 45.4 0.2 16.3 17.1 10.5 3.2 3.9 8.3 8.5 11.0 10.7 5.3 7.2 11.1 1.8 3.4 8.2 9.6 0.7 13.3 8.6 3.3 13.1 5.3 3.6 3.8 3.3 4.5 3.7 3.9 5.1 3.9 4.2 7.0 4.1 3.7 9.7 9.6 4.8 0.7 2.5 1.7 4.5 5.7 2.2 0.2 8.4 8.3 1.4 8.6 6.9 0.0 0.0 4.6 3.0 6.2 46.9 5.9 1.6 20.1 2.5 8.4 3.0 1.3 0.5 11.1 31.9 7.1 4.1 6.3 0.0 8.5 11.0 5.5 8.7 0.0 0.6 3.5 6.1 6.3 0.8 1.7 3.7 3.8 3.6 0.0 1.6 5.1 8.2 2.0 0.3 13.4 3.2 7.2 2.3 2.5 5.4 8.0 12.2 0.3 6.6 8.0 2.5 10.9 1.0 4.0 1.0 1.5 5.0 5.5 2.8 2.9 USP19 "KIAA0891, ZMYND9" ENSG00000172046 "Ubiquitin specific peptidase 19" O94966 3 49108046-49120938 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 16: U-266 - Nucleosome" "Cluster 10: Non-specific - Unknown function" "unprognostic (3.23e-2)" "unprognostic (2.12e-1)" "unprognostic (5.91e-2)" "unprognostic (1.37e-1)" "unprognostic (1.92e-2)" "unprognostic (3.90e-3)" "unprognostic (2.99e-2)" "unprognostic (3.00e-3)" "unprognostic (2.69e-1)" "unprognostic (3.65e-2)" "unprognostic (2.31e-2)" "unprognostic (1.26e-1)" "prognostic favorable (7.05e-9)" "unprognostic (2.99e-1)" "unprognostic (2.11e-1)" "unprognostic (1.72e-3)" "unprognostic (7.54e-2)" 20.3 25.5 16.4 19.4 18.7 26.8 19.6 19.0 18.6 21.9 24.4 26.2 22.4 24.3 19.1 19.7 24.3 15.5 26.8 17.4 16.8 18.9 18.6 17.7 21.5 19.0 17.5 22.8 21.2 31.0 17.5 16.5 17.9 19.4 15.9 14.3 29.6 24.4 75.6 26.5 21.9 18.9 16.7 22.9 21.6 20.8 18.4 27.4 23.6 45.0 16.8 23.3 19.6 19.5 20.2 26.3 28.6 42.1 36.8 24.1 38.7 23.1 26.1 35.1 28.7 28.7 27.3 41.6 22.2 24.4 36.2 24.1 40.3 29.1 16.0 32.7 32.1 42.5 56.4 22.8 36.1 45.7 40.5 33.8 22.7 36.9 24.1 25.9 24.2 33.8 30.8 28.4 18.9 23.9 42.6 43.0 58.2 27.4 44.1 19.4 24.3 45.7 22.3 37.4 16.5 51.4 33.3 38.1 34.9 26.1 26.0 55.4 21.8 24.5 30.5 36.7 33.7 77.7 97.1 38.0 32.8 34.3 32.6 9.7 3.7 5.3 4.5 3.6 4.2 2.8 3.7 5.2 4.6 2.9 3.3 3.9 7.5 2.9 4.4 1.9 2.7 4.3 16.4 18.7 19.0 18.6 17.4 16.8 19.0 17.5 17.9 16.7 18.4 19.5 7.8 12.8 14.5 10.4 7.2 6.2 3.8 8.5 8.6 12.7 8.7 7.4 13.1 5.7 9.9 7.3 18.8 9.6 9.2 17.1 5.9 7.7 3.6 14.8 8.7 7.6 9.1 10.3 8.4 7.8 5.3 7.7 14.3 9.5 2.5 8.1 7.9 13.6 9.0 13.5 8.0 11.6 10.2 8.7 4.7 4.9 13.1 6.8 3.6 2.8 6.5 8.7 3.1 8.0 7.7 11.5 13.9 12.4 7.4 4.2 16.3 7.7 14.9 11.4 13.1 12.3 11.1 16.2 13.2 9.1 5.4 13.5 8.0 9.8 13.4 3.1 USP2 UBP41 ENSG00000036672 "Ubiquitin specific peptidase 2" O75604 11 119355215-119381711 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Biological rhythms, Cell cycle, Myogenesis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 168.3" "Group enriched" "Detected in many" 5 "Early spermatids: 460.0;Late spermatids: 1094.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "K-562: 14.5;U-266/70: 56.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006777, HPA007222" Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 54: Non-specific - Microtubule organization" "Cluster 29: U-266 - Adaptive immune response" "Cluster 31: Spermatids - Spermatogenesis" Cytosol "Plasma membrane" "HPA006777: AB_1080507, HPA007222: AB_1080505" "unprognostic (6.83e-2)" "unprognostic (2.02e-2)" "unprognostic (5.54e-2)" "unprognostic (1.37e-2)" "unprognostic (1.25e-1)" "unprognostic (7.46e-3)" "unprognostic (1.00e-1)" "unprognostic (5.27e-2)" "unprognostic (1.24e-1)" "unprognostic (5.24e-3)" "unprognostic (8.02e-3)" "unprognostic (7.33e-2)" "prognostic favorable (3.09e-11)" "unprognostic (1.58e-1)" "unprognostic (1.20e-1)" "unprognostic (1.96e-2)" "unprognostic (2.66e-2)" 7.0 13.4 11.9 1.6 22.6 1.9 4.1 18.8 19.0 6.0 32.7 10.2 13.9 5.2 5.7 9.8 11.6 2.3 73.5 18.6 9.4 53.4 18.9 3.4 0.1 12.0 13.1 6.2 18.1 24.2 18.9 1.3 7.7 4.1 6.0 76.2 7.6 3.0 168.3 12.8 17.4 6.8 8.2 0.6 6.2 86.5 15.1 0.6 3.8 62.8 0.6 4.5 4.8 17.5 6.0 0.5 0.9 3.2 0.1 0.2 1.3 0.7 0.4 0.0 0.6 6.1 0.8 10.2 1.8 1.1 1.4 1.0 7.9 2.9 0.2 7.2 1.0 2.8 4.4 12.5 2.7 0.0 2.8 0.9 0.6 0.7 2.0 1.3 0.6 7.6 14.5 0.8 1.7 4.1 0.0 0.6 1.6 2.0 1.3 0.1 2.1 1.5 4.6 0.3 11.9 3.6 3.4 2.6 0.7 1.7 8.8 6.2 0.0 0.0 1.5 0.8 1.0 56.9 13.5 0.2 0.1 2.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.9 22.6 18.8 19.0 18.6 9.4 12.0 13.1 7.7 8.2 15.1 17.5 0.6 3.2 2.7 10.7 0.6 2.4 5.3 1.5 1.2 75.2 3.3 2.4 85.2 7.2 6.1 5.5 95.9 0.5 1.6 25.5 113.5 3.1 460.0 39.0 3.0 3.6 0.0 0.4 15.7 1.6 0.9 7.4 2.0 8.4 0.0 2.0 2.2 23.0 17.2 10.1 11.6 2.0 0.0 1.3 2.9 1094.1 6.5 2.1 0.0 1.9 0.0 49.7 0.0 8.0 12.5 1.2 11.8 7.2 0.1 1.1 41.3 41.6 35.0 140.0 19.7 43.3 24.0 50.5 16.5 12.9 4.0 1.4 1.3 0.5 2.6 2.9 USP20 KIAA1003 ENSG00000136878 "Ubiquitin specific peptidase 20" Q9Y2K6 9 129834698-129881828 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Endocytosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "JURKAT: 95.9;K-562: 60.2;MOLT-4: 56.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006287, HPA007008" Uncertain Supported Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 58: T-cells - T-cell receptor" "Nucleoplasm, Plasma membrane, Cytosol" "HPA006287: AB_1080510, HPA007008: " "unprognostic (2.64e-2)" "prognostic favorable (8.01e-4)" "prognostic unfavorable (2.48e-4)" "prognostic favorable (4.01e-4)" "unprognostic (4.69e-1)" "unprognostic (1.89e-2)" "unprognostic (2.25e-1)" "unprognostic (2.55e-3)" "unprognostic (1.24e-1)" "unprognostic (7.89e-2)" "prognostic favorable (1.54e-7)" "unprognostic (2.09e-1)" "prognostic favorable (5.65e-5)" "unprognostic (1.76e-2)" "unprognostic (1.20e-1)" "unprognostic (1.19e-2)" "unprognostic (1.24e-2)" 8.1 12.0 8.7 13.5 8.0 22.6 8.3 4.8 8.7 12.5 2.5 13.6 8.2 12.5 4.2 7.9 12.1 7.7 7.5 7.8 10.6 7.6 7.4 8.4 18.3 10.2 9.1 13.5 10.9 8.4 18.4 6.7 10.0 14.8 4.9 6.7 11.4 13.2 10.9 12.1 12.5 8.2 5.4 13.9 9.9 10.0 8.9 32.3 18.7 7.5 11.8 14.9 10.1 6.5 6.0 5.8 10.0 13.4 12.8 10.8 14.1 9.5 7.9 7.1 4.9 4.7 6.5 8.1 8.0 9.3 8.0 14.7 6.0 6.7 2.9 43.4 7.9 14.9 17.0 3.3 8.8 14.2 10.6 9.6 9.8 9.3 7.0 12.4 7.7 95.9 60.2 9.9 4.4 15.9 56.4 33.6 7.9 12.7 13.6 9.4 11.2 14.0 5.5 6.5 2.2 11.0 11.0 13.9 9.1 5.9 14.4 19.9 11.5 7.8 3.5 10.5 6.3 9.7 15.3 5.7 15.5 18.6 7.4 1.0 1.9 5.4 8.6 1.5 9.1 3.7 8.7 8.3 2.6 3.4 9.8 8.9 2.8 10.0 1.5 2.1 11.5 6.3 8.7 8.0 4.8 8.7 7.8 10.6 10.2 9.1 10.0 5.4 8.9 6.5 3.0 9.6 6.9 16.3 9.2 2.8 2.2 2.5 4.0 7.8 6.4 8.0 7.7 4.3 3.0 1.8 4.2 5.9 9.4 6.2 3.9 2.4 2.1 4.1 6.3 4.3 8.4 12.8 17.0 4.0 2.5 4.6 8.2 5.7 1.3 6.8 6.4 6.1 3.3 10.1 21.1 4.6 4.1 1.6 3.8 3.3 6.2 6.0 3.6 11.2 3.1 5.3 11.3 9.5 14.3 2.7 5.0 4.9 6.7 3.0 4.1 2.9 5.0 6.3 0.0 4.3 5.7 12.1 6.0 4.8 2.0 6.2 19.3 2.9 5.2 1.6 USP21 "USP16, USP23" ENSG00000143258 "Ubiquitin specific peptidase 21" Q9UK80 1 161159450-161165723 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 16.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA028397 Uncertain Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 80: Striated muscle - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 59: Non-specific - Transcription" Cytosol "Nucleoplasm, Plasma membrane" "HPA028397: AB_10603227" "unprognostic (9.17e-2)" "unprognostic (1.44e-1)" "unprognostic (3.95e-2)" "prognostic unfavorable (7.05e-4)" "unprognostic (1.22e-2)" "unprognostic (1.26e-2)" "prognostic unfavorable (1.68e-4)" "unprognostic (5.35e-2)" "unprognostic (6.73e-2)" "unprognostic (2.76e-2)" "unprognostic (3.87e-3)" "unprognostic (1.31e-2)" "prognostic unfavorable (9.50e-6)" "unprognostic (2.45e-1)" "unprognostic (3.28e-1)" "unprognostic (2.13e-2)" "prognostic favorable (3.35e-5)" 12.2 15.3 19.6 11.9 20.7 15.0 14.3 18.5 22.8 19.4 18.3 17.6 13.6 18.2 12.0 16.4 28.0 12.0 13.0 19.4 18.4 14.5 10.8 13.1 16.1 19.2 19.7 23.2 16.4 17.1 15.7 13.2 18.7 17.7 11.0 12.9 16.5 20.3 20.9 20.8 15.9 12.6 17.3 17.8 16.4 14.2 20.1 18.4 18.5 17.7 14.0 17.6 16.8 22.1 12.5 20.6 26.9 26.2 21.1 17.5 16.5 9.1 14.6 24.2 18.9 19.4 23.3 16.0 14.6 11.2 15.1 20.7 17.6 17.5 13.2 30.8 30.0 19.3 34.1 15.3 15.2 17.4 13.4 14.8 23.0 16.6 23.9 27.1 17.3 35.0 28.4 21.6 15.6 22.6 30.7 26.9 25.2 24.3 26.1 28.8 9.0 26.5 14.4 14.9 24.2 31.5 17.2 17.2 13.9 20.1 37.3 27.5 10.1 16.9 14.8 11.9 15.3 42.9 36.5 23.9 15.3 14.7 15.5 15.2 10.0 17.1 12.6 6.4 14.6 11.0 11.5 13.2 10.8 11.3 13.1 12.3 8.4 13.3 7.6 10.8 12.3 11.0 19.6 20.7 18.5 22.8 19.4 18.4 19.2 19.7 18.7 17.3 20.1 22.1 4.5 0.0 3.7 5.2 6.5 1.5 1.8 2.4 16.5 5.0 4.9 4.1 3.9 8.6 2.9 1.8 6.2 4.9 3.6 3.6 1.9 2.0 1.0 6.3 5.7 4.4 5.4 10.7 2.4 2.3 2.3 5.1 9.2 3.7 2.5 4.5 5.3 2.1 2.2 0.0 2.7 4.0 4.1 4.8 0.8 1.0 5.0 2.1 1.8 1.9 1.2 3.3 5.2 2.0 4.6 2.0 2.4 4.1 7.8 2.7 3.5 2.5 9.5 5.2 6.6 2.0 5.2 5.3 3.2 10.7 1.4 3.1 5.6 3.1 4.1 1.5 USP22 "KIAA1063, USP3L" ENSG00000124422 "Ubiquitin specific peptidase 22" Q9UPT9 17 20999596-21043760 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044980 Supported Approved "Nuclear speckles" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 52: Non-specific - Transcription" "Nuclear speckles" "HPA044980: AB_10794503" "unprognostic (7.24e-2)" "unprognostic (5.38e-2)" "unprognostic (7.67e-2)" "unprognostic (6.19e-2)" "unprognostic (4.72e-1)" "unprognostic (1.11e-2)" "prognostic unfavorable (9.66e-4)" "unprognostic (2.17e-2)" "unprognostic (7.81e-2)" "unprognostic (6.37e-2)" "unprognostic (1.07e-3)" "unprognostic (5.68e-2)" "prognostic favorable (1.53e-7)" "unprognostic (8.95e-2)" "unprognostic (1.93e-1)" "unprognostic (2.91e-1)" "unprognostic (1.79e-2)" 40.7 66.8 91.2 40.3 93.7 53.0 42.5 72.0 90.5 55.3 44.8 48.8 33.6 63.7 48.2 40.7 57.3 40.0 79.8 93.1 112.3 49.5 44.1 46.3 48.3 71.7 78.1 75.6 48.0 68.2 65.2 39.3 85.8 50.2 35.2 57.1 36.3 48.2 108.6 40.3 39.5 54.0 72.4 45.1 49.8 29.3 120.3 63.9 57.0 81.2 50.2 42.3 35.4 68.4 106.9 189.7 179.9 155.5 102.7 105.9 85.9 120.2 91.8 105.6 89.3 220.0 46.9 145.4 112.5 185.2 71.3 111.7 176.7 143.1 157.1 70.0 122.8 120.8 121.5 107.9 121.3 134.2 101.0 117.4 83.9 119.9 125.1 119.8 134.1 93.3 139.7 51.4 151.6 109.5 189.8 63.7 93.1 125.5 61.9 206.2 284.5 99.2 97.7 153.9 86.3 177.8 154.9 63.5 124.9 488.4 106.4 78.0 171.0 107.4 140.8 111.3 164.1 55.0 79.6 476.2 109.0 70.3 169.4 5.5 9.6 10.0 7.9 7.6 7.9 8.0 8.1 7.8 9.2 9.9 10.7 10.2 9.9 7.1 9.7 7.6 6.1 6.0 91.2 93.7 72.0 90.5 93.1 112.3 71.7 78.1 85.8 72.4 120.3 68.4 46.6 41.7 48.8 31.6 47.9 33.0 43.8 33.8 38.7 97.6 80.3 63.8 23.8 45.8 41.5 60.7 93.8 51.4 36.6 59.3 23.5 51.6 36.0 59.3 75.3 56.1 88.2 43.7 53.1 59.0 37.5 51.0 57.6 68.7 30.4 86.5 76.8 68.5 38.1 117.8 66.0 48.8 30.5 53.8 36.1 51.2 51.0 31.7 35.6 43.1 42.2 55.4 28.8 38.7 50.6 69.6 40.3 71.8 36.6 62.2 33.4 48.9 37.4 59.1 13.1 58.6 52.2 15.9 19.7 49.6 29.1 65.8 33.4 77.9 53.3 53.5 USP24 KIAA1057 ENSG00000162402 "Ubiquitin specific peptidase 24" Q9UPU5 1 55066359-55215364 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in many" 4 "Oligodendrocyte precursor cells: 552.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026723, HPA028428, HPA067124" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 1: K-562 - Erythropoiesis" "Cluster 68: Oligodendrocytes - Mixed function" Nucleoplasm Cytosol "HPA026723: AB_10599851, HPA028428: AB_10600991, HPA067124: AB_2685785" "unprognostic (2.28e-1)" "unprognostic (9.81e-3)" "unprognostic (4.70e-3)" "unprognostic (4.86e-3)" "unprognostic (9.31e-3)" "unprognostic (4.84e-3)" "prognostic unfavorable (1.34e-7)" "unprognostic (2.04e-1)" "unprognostic (6.93e-2)" "unprognostic (2.98e-1)" "unprognostic (5.08e-2)" "unprognostic (1.86e-1)" "unprognostic (8.12e-2)" "unprognostic (1.79e-1)" "unprognostic (6.42e-2)" "unprognostic (4.12e-2)" "unprognostic (1.64e-1)" 16.6 8.2 13.4 14.2 13.3 56.7 13.4 25.3 13.6 9.4 13.2 12.0 8.3 10.7 9.2 9.4 9.9 9.0 12.7 12.6 14.7 15.7 15.3 10.6 22.1 13.5 13.1 16.5 11.4 20.3 12.8 9.6 14.6 10.2 13.3 17.2 12.8 9.6 47.9 13.6 12.6 9.8 12.8 18.6 12.3 8.4 13.6 21.9 9.2 36.6 20.9 10.4 9.2 14.2 32.5 17.4 21.3 11.6 27.2 23.5 24.6 14.0 17.5 19.6 20.3 25.0 11.1 25.9 15.1 26.1 40.1 25.6 28.5 23.6 30.5 27.2 17.4 51.5 40.2 29.6 16.1 36.0 38.6 21.0 20.6 30.0 33.7 19.0 18.2 25.7 48.5 10.6 26.6 7.6 21.9 19.1 31.4 15.5 21.0 22.3 27.1 11.3 34.6 21.4 18.7 13.1 23.8 16.8 21.1 32.3 11.7 17.5 24.7 17.9 17.3 21.7 22.6 13.2 10.6 33.2 16.9 29.4 16.3 5.4 1.3 1.7 2.8 1.1 1.7 3.0 2.2 2.2 1.2 3.4 1.9 2.5 1.4 2.3 1.5 6.9 1.3 0.7 13.4 13.3 25.3 13.6 12.6 14.7 13.5 13.1 14.6 12.8 13.6 14.2 20.4 16.0 20.0 92.4 27.7 14.9 8.4 5.6 9.1 14.0 13.4 10.2 37.7 10.0 13.0 12.9 73.0 4.2 42.6 11.1 0.0 10.3 0.7 11.9 15.1 16.1 17.3 37.4 84.5 10.2 7.8 11.9 21.4 15.0 12.7 18.2 12.1 11.9 9.7 38.7 100.4 16.2 8.2 19.2 18.8 2.5 11.8 18.6 10.6 87.1 19.6 7.0 15.5 552.4 115.2 11.8 11.4 7.9 18.1 12.7 8.3 5.9 10.0 16.9 6.6 18.0 13.5 7.7 7.1 13.9 17.2 1.5 21.8 9.8 16.0 12.1 USP25 USP21 ENSG00000155313 "Ubiquitin specific peptidase 25" Q9UHP3 21 15730025-15880069 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 120.9" "Cell type enhanced" "Detected in all" "Early spermatids: 166.7;Excitatory neurons: 148.0;Late spermatids: 192.8;Oligodendrocyte precursor cells: 150.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018297, HPA024142" Approved Supported Cytosol NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 30: Epithelial cell lines - Translation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "HPA018297: AB_1858672, HPA024142: AB_1858673" "unprognostic (6.35e-2)" "unprognostic (1.50e-1)" "unprognostic (6.90e-2)" "unprognostic (6.29e-2)" "unprognostic (1.39e-1)" "unprognostic (2.88e-2)" "unprognostic (3.91e-2)" "unprognostic (1.65e-1)" "unprognostic (1.44e-2)" "unprognostic (1.38e-1)" "unprognostic (2.33e-2)" "unprognostic (1.40e-1)" "unprognostic (8.24e-3)" "unprognostic (2.34e-3)" "unprognostic (4.50e-2)" "unprognostic (1.61e-1)" "unprognostic (2.32e-2)" 25.8 12.9 13.4 16.8 20.1 26.9 17.6 12.6 17.2 18.1 12.3 15.3 12.6 26.8 18.7 21.4 16.8 12.4 28.1 16.2 4.2 21.4 20.2 24.0 20.1 4.7 4.3 14.1 15.9 14.3 7.6 29.4 4.8 17.9 16.1 9.5 17.5 24.6 120.9 13.1 13.3 36.4 4.4 19.5 13.1 54.5 4.9 25.6 15.5 75.1 19.3 15.5 17.3 11.9 31.2 23.1 21.5 3.2 38.7 57.5 25.3 22.0 21.8 16.0 20.1 20.5 17.4 33.6 31.5 34.9 24.3 16.4 16.7 29.1 22.0 33.5 19.1 27.5 23.5 15.8 64.3 36.6 12.1 37.6 34.7 25.8 74.0 41.7 57.0 30.0 35.9 61.4 29.1 13.0 42.1 7.1 26.6 12.5 20.3 31.8 20.0 25.8 43.5 8.3 4.7 12.8 31.4 26.2 20.9 25.9 14.0 21.3 54.6 24.8 16.0 26.2 12.5 17.7 11.9 26.8 16.0 16.1 18.6 0.0 1.4 1.9 1.8 1.4 2.0 1.6 1.5 3.2 1.2 1.1 1.4 2.1 2.9 1.1 1.3 1.3 2.2 0.8 13.4 20.1 12.6 17.2 16.2 4.2 4.7 4.3 4.8 4.4 4.9 11.9 30.4 57.7 29.5 47.3 21.7 17.1 18.8 9.7 15.9 6.2 17.4 11.8 55.7 15.7 24.2 22.0 4.2 39.0 21.4 20.3 5.9 9.4 166.7 24.0 19.0 19.7 9.6 21.5 148.0 13.4 8.4 19.4 17.9 34.6 6.3 14.4 17.9 18.0 13.3 5.0 98.4 12.8 8.2 24.2 16.0 192.8 19.0 24.2 16.0 86.2 23.7 4.0 23.7 150.3 72.4 13.4 8.4 12.8 15.9 22.0 11.9 15.1 23.4 6.7 19.7 26.1 17.2 11.2 5.8 22.7 19.2 33.1 26.9 18.5 11.6 20.4 USP26 ENSG00000134588 "Ubiquitin specific peptidase 26" Q9BXU7 X 133024631-133097109 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 13 "Spermatogonia: 4.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA000424, HPA027310, HPA079124" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" Nucleoplasm Cytosol "HPA000424: , HPA027310: , HPA079124: " "unprognostic (7.92e-4)" "unprognostic (3.59e-2)" "unprognostic (1.99e-2)" "unprognostic (2.08e-1)" 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 USP27X USP27 ENSG00000273820 "Ubiquitin specific peptidase 27 X-linked" A6NNY8 X 49879484-49882558 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 14.4" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 19.2;Alveolar cells type 2: 15.5;Bipolar cells: 15.8;Cytotrophoblasts: 44.5;Syncytiotrophoblasts: 26.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "SuSa: 12.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA077264 Approved Nucleoplasm,Vesicles NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 12: NES - Nervous system development" "Cluster 47: Cytotrophoblasts - Unknown function" Vesicles Nucleoplasm "HPA077264: AB_2686831" "unprognostic (4.12e-2)" "unprognostic (9.58e-3)" "unprognostic (2.29e-1)" "unprognostic (4.66e-2)" "unprognostic (1.98e-1)" "unprognostic (1.74e-1)" "prognostic unfavorable (6.14e-4)" "unprognostic (3.10e-3)" "unprognostic (3.91e-2)" "unprognostic (1.31e-2)" "prognostic favorable (9.31e-4)" "unprognostic (5.37e-2)" "unprognostic (7.45e-3)" "unprognostic (1.19e-1)" "unprognostic (1.12e-1)" "unprognostic (2.01e-2)" "unprognostic (2.58e-1)" 1.6 2.5 6.0 1.3 6.2 0.5 2.0 8.0 5.8 3.0 3.1 3.2 1.0 3.9 2.9 1.6 3.5 1.6 1.8 5.3 14.4 2.7 1.8 2.7 1.7 4.9 8.4 6.3 2.6 3.0 7.3 11.7 5.9 3.0 1.4 3.8 1.6 2.8 4.4 2.1 2.1 2.8 3.6 1.8 2.4 1.3 10.5 2.6 2.4 2.1 1.7 3.0 2.2 4.4 1.6 3.8 4.2 4.8 3.8 3.1 3.6 1.6 2.6 1.8 1.4 6.9 1.6 0.9 1.6 4.2 6.0 2.6 6.0 4.0 2.6 2.0 3.1 1.6 1.1 6.2 2.6 0.5 3.4 4.4 2.7 2.6 2.6 4.4 2.5 4.2 3.4 1.5 2.9 3.7 2.5 1.2 4.8 2.7 2.7 2.7 3.7 0.3 2.9 1.4 1.1 3.2 3.4 3.0 4.0 12.9 3.5 1.1 1.9 2.1 4.3 3.8 0.7 1.6 0.4 0.6 2.5 1.4 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 6.0 6.2 8.0 5.8 5.3 14.4 4.9 8.4 5.9 3.6 10.5 4.4 3.5 19.2 15.5 0.7 2.5 2.9 4.5 0.3 2.2 15.8 1.9 2.7 2.6 0.0 7.5 0.0 0.0 44.5 1.4 1.7 5.9 1.5 0.1 2.1 4.1 5.2 4.2 0.0 2.9 0.7 3.6 2.7 1.1 2.1 2.5 4.0 2.5 1.9 4.0 5.0 3.3 1.3 0.0 0.6 1.0 0.3 2.1 1.2 0.0 0.0 1.5 8.3 0.0 3.5 0.8 1.2 0.5 3.4 0.5 3.3 0.5 2.9 13.2 2.5 6.6 2.5 2.6 0.2 1.3 0.9 2.3 26.1 2.0 8.8 1.6 1.7 USP28 KIAA1515 ENSG00000048028 "Ubiquitin specific peptidase 28" Q96RU2 11 113797874-113875570 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 62.7;skeletal muscle: 68.3;tongue: 66.5" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 152.2;Excitatory neurons: 57.0;NK-cells: 73.2" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebellum: 20.1" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006778, HPA006779" Enhanced Supported "Nucleoplasm,Nuclear bodies" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 38: Heart - Muscle contraction" "Cluster 12: NES - Nervous system development" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm "Nuclear bodies" "HPA006778: AB_1080520, HPA006779: AB_1080517" "unprognostic (2.54e-1)" "unprognostic (2.72e-1)" "unprognostic (2.99e-2)" "unprognostic (3.72e-2)" "unprognostic (5.51e-2)" "unprognostic (2.30e-1)" "unprognostic (9.73e-3)" "unprognostic (3.00e-1)" "unprognostic (2.04e-3)" "unprognostic (1.82e-3)" "unprognostic (3.17e-2)" "unprognostic (1.19e-1)" "unprognostic (5.11e-2)" "unprognostic (2.06e-2)" "unprognostic (9.03e-2)" "unprognostic (1.35e-3)" "unprognostic (5.03e-2)" 5.8 6.7 3.2 9.5 4.3 5.8 10.4 20.1 9.5 21.1 0.6 10.4 9.6 11.5 11.3 9.6 9.8 7.7 62.7 4.6 1.8 9.9 11.3 7.5 15.6 2.1 1.7 14.1 8.2 15.5 7.4 8.0 3.4 11.3 11.7 27.1 12.0 14.2 68.3 7.0 10.4 13.1 1.2 13.8 9.2 9.2 1.9 9.0 10.1 66.5 15.5 9.8 8.4 5.3 18.3 20.2 26.7 35.4 21.3 20.9 18.8 13.2 18.0 17.5 29.7 30.2 25.6 24.2 29.3 18.0 40.1 35.1 37.9 24.8 24.1 27.1 17.2 12.9 13.8 16.3 13.0 16.8 12.4 12.6 18.5 20.2 23.8 25.4 32.0 11.9 22.7 15.3 18.5 9.3 12.9 27.1 32.0 33.6 14.4 31.3 37.1 29.4 19.3 17.8 11.6 12.6 31.4 10.7 10.1 82.7 25.8 5.8 17.1 19.2 28.3 17.8 13.8 10.4 15.9 20.1 1.9 32.1 12.8 0.2 5.0 3.4 23.2 3.7 12.1 15.5 5.7 16.8 6.4 12.3 3.8 13.1 1.4 28.6 6.4 1.9 9.2 10.3 3.2 4.3 20.1 9.5 4.6 1.8 2.1 1.7 3.4 1.2 1.9 5.3 7.3 9.6 8.8 18.3 17.8 1.7 7.3 9.9 13.6 18.7 9.7 9.8 152.2 5.7 9.9 5.5 18.8 4.4 32.1 3.3 5.9 6.7 1.7 6.6 11.6 7.9 4.9 2.5 57.0 3.9 4.7 12.2 11.7 8.7 1.3 18.9 7.5 8.8 4.4 5.0 34.1 9.6 4.1 6.5 2.5 2.0 6.8 7.4 1.8 10.3 8.2 10.3 73.2 29.1 21.3 3.5 5.3 13.9 21.7 7.1 7.3 7.1 14.6 21.5 6.6 10.3 11.0 15.8 11.4 7.7 2.0 1.1 18.6 9.0 8.9 5.8 USP29 ENSG00000131864 "Ubiquitin specific peptidase 29" Q9HBJ7 19 57119138-57131926 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "testis: 4.9" "Group enriched" "Detected in some" 8 "Collecting duct cells: 1.8;Early spermatids: 2.2;Spermatocytes: 5.1;Spermatogonia: 1.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected" "Not detected" HPA076515 Enhanced NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 21: Non-specific - Transcription" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA076515: " "unprognostic (1.32e-1)" 0.1 0.0 0.9 0.0 0.5 1.8 0.0 2.1 0.6 0.0 1.0 0.1 0.1 0.2 0.0 0.2 0.1 0.2 0.5 1.0 1.0 0.1 0.1 0.2 0.4 1.9 0.9 0.3 1.3 0.0 0.0 0.2 0.8 0.1 0.1 0.6 0.7 0.0 0.3 1.4 0.0 0.0 0.8 0.2 0.4 4.9 0.8 0.0 0.3 0.0 0.1 0.3 0.0 2.0 0.0 0.2 0.2 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.3 0.9 0.2 0.0 0.0 0.3 0.0 0.5 0.2 0.3 0.4 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.2 0.0 0.3 0.0 0.1 0.3 0.2 0.0 0.2 0.0 0.6 0.5 0.2 0.1 0.1 0.1 0.3 0.2 0.3 0.4 0.3 0.1 0.0 0.0 0.4 0.1 0.3 0.1 0.2 0.0 1.3 0.3 0.3 0.2 0.2 0.1 0.2 0.1 0.1 0.1 0.2 0.1 0.1 1.1 0.3 0.1 0.6 0.1 0.2 0.9 0.5 2.1 0.6 1.0 1.0 1.9 0.9 0.8 0.8 0.8 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 5.1 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.2 USP3 ENSG00000140455 "Ubiquitin specific peptidase 3" Q9Y6I4 15 63504511-63594640 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, DNA damage, Ubl conjugation pathway" "Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in all" 4 "cerebellum: 36.4" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA053275, HPA060513, HPA077975" Supported "Nucleoplasm,Midbody ring" "Intracellular and membrane" Yes No "Cluster 1: Neutrophils - Mixed function" "Cluster 50: Non-specific - Ribosome" "Cluster 15: RT4 - Unknown function" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Nucleoplasm "Midbody ring" "HPA053275: AB_2682096, HPA060513: AB_2684299, HPA077975: AB_2732365" "unprognostic (4.63e-3)" "unprognostic (2.71e-1)" "unprognostic (7.88e-2)" "unprognostic (3.33e-2)" "unprognostic (2.16e-2)" "unprognostic (6.03e-2)" "unprognostic (6.26e-2)" "unprognostic (4.52e-2)" "unprognostic (1.62e-2)" "unprognostic (2.36e-1)" "unprognostic (3.54e-2)" "unprognostic (4.87e-2)" "unprognostic (1.17e-1)" "unprognostic (8.61e-2)" "unprognostic (2.78e-1)" "unprognostic (6.21e-2)" "prognostic favorable (1.38e-4)" 12.7 8.2 5.8 5.4 7.0 21.4 11.2 36.4 5.9 11.7 15.4 13.4 6.5 12.9 4.7 10.9 10.9 5.4 6.0 5.3 6.3 10.1 8.2 13.2 6.5 6.9 6.9 16.2 18.9 3.1 6.2 2.7 7.6 10.4 5.6 6.3 12.4 6.0 10.0 14.6 13.9 4.5 5.3 17.6 15.7 5.3 8.6 7.4 9.1 3.6 6.4 12.4 11.9 7.5 10.4 21.0 12.1 8.1 5.5 7.6 8.2 6.7 9.6 7.1 5.8 6.6 13.1 8.7 15.3 9.3 3.6 12.0 11.6 11.1 5.6 12.2 5.8 10.4 8.6 9.8 6.8 6.4 11.4 11.3 7.8 7.7 10.6 8.9 12.4 17.3 9.5 9.0 3.3 5.2 11.0 8.8 16.2 13.7 5.3 22.2 8.4 11.3 4.5 23.8 9.6 9.5 3.3 13.0 6.7 7.8 5.5 9.5 13.4 7.2 16.9 3.3 10.3 9.3 24.4 18.2 7.4 13.8 7.5 120.0 84.7 12.7 24.8 66.0 28.4 34.1 34.3 26.0 59.8 34.8 34.0 25.2 169.1 19.8 65.4 13.1 28.1 45.2 5.8 7.0 36.4 5.9 5.3 6.3 6.9 6.9 7.6 5.3 8.6 7.5 23.6 38.5 69.2 76.7 63.4 52.6 34.3 24.8 23.3 31.4 27.9 20.3 9.2 25.8 41.4 16.5 12.5 19.8 48.4 37.6 41.1 41.0 21.6 37.8 32.8 26.0 43.8 15.8 11.2 37.2 57.3 28.3 39.8 74.6 27.1 64.5 11.4 24.0 24.8 13.5 40.0 35.4 30.5 78.4 109.6 77.4 15.8 74.5 42.7 75.9 101.8 25.9 41.2 80.4 40.6 39.8 35.6 18.4 69.7 40.6 33.2 28.3 33.3 17.9 13.1 25.3 34.5 14.8 40.3 33.9 59.0 34.1 64.6 40.1 40.6 37.6 USP30 "FLJ40511, MGC10702" ENSG00000135093 "Ubiquitin specific peptidase 30" Q70CQ3 12 109023089-109088023 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 52.7;Oligodendrocytes: 41.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016952 Approved NA NA "Cluster 44: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 25: Spermatids - Spermatogenesis" "HPA016952: AB_1858680" "unprognostic (2.34e-1)" "unprognostic (1.57e-2)" "unprognostic (7.04e-2)" "unprognostic (9.91e-2)" "unprognostic (2.48e-1)" "unprognostic (5.89e-2)" "unprognostic (1.91e-1)" "unprognostic (3.60e-3)" "unprognostic (1.98e-1)" "unprognostic (4.96e-2)" "unprognostic (5.07e-2)" "unprognostic (1.07e-1)" "prognostic favorable (5.23e-6)" "unprognostic (2.49e-1)" "unprognostic (1.23e-1)" "unprognostic (1.12e-1)" "unprognostic (1.02e-3)" 8.4 8.8 2.9 7.3 6.0 10.7 6.5 4.2 5.4 6.6 1.9 10.2 11.4 7.8 4.7 5.6 8.0 5.9 6.8 3.3 6.9 9.1 16.3 6.8 8.8 5.2 4.3 12.4 8.6 14.4 4.2 5.1 5.5 6.8 8.4 10.7 7.7 6.7 10.0 6.6 11.1 6.2 3.0 7.9 6.5 13.8 5.0 6.3 8.2 8.7 4.5 4.3 3.3 14.1 5.3 4.1 10.7 9.2 7.3 8.3 5.9 5.9 7.8 6.8 5.9 4.9 3.9 13.6 4.8 5.9 6.1 5.6 9.4 6.3 7.7 16.0 11.7 4.2 3.8 7.1 7.8 8.7 4.6 10.1 7.4 5.9 6.0 17.5 8.0 13.8 6.8 6.1 5.9 6.3 13.8 5.0 3.2 6.3 11.3 14.7 7.6 8.1 5.4 6.4 9.7 8.6 8.0 5.6 6.3 7.8 14.5 6.8 5.5 5.9 3.3 5.9 3.7 16.0 14.4 19.3 6.5 5.0 6.9 14.0 8.4 16.2 17.5 14.0 20.2 17.3 14.7 16.8 5.6 17.0 15.2 14.1 5.1 23.3 11.7 15.2 14.4 7.4 2.9 6.0 4.2 5.4 3.3 6.9 5.2 4.3 5.5 3.0 5.0 14.1 3.9 0.0 4.6 10.7 2.5 2.0 2.2 4.1 6.2 9.1 4.8 4.1 8.6 10.0 5.6 5.5 8.4 5.7 3.4 14.3 0.0 4.7 27.3 3.6 3.8 3.6 6.7 5.7 18.8 5.7 4.2 4.4 1.5 3.2 0.0 11.8 4.2 18.3 5.7 6.7 22.7 8.4 0.0 3.5 1.4 52.7 3.7 2.2 1.8 7.5 3.5 6.9 4.1 16.6 41.8 5.3 5.6 3.8 6.7 1.9 13.3 7.3 5.2 14.9 13.1 5.2 3.5 26.1 5.6 4.7 3.3 7.3 3.4 5.0 9.9 2.7 USP31 KIAA1203 ENSG00000103404 "Ubiquitin specific peptidase 31" Q70CQ4 16 23061406-23149270 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 31.2" "Cell type enhanced" "Detected in many" "Oligodendrocytes: 198.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006937 Uncertain Approved Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 30: Epithelial cell lines - Translation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "HPA006937: AB_1080523" "unprognostic (6.45e-2)" "unprognostic (2.42e-1)" "unprognostic (1.08e-1)" "unprognostic (4.43e-3)" "unprognostic (1.24e-1)" "unprognostic (1.28e-1)" "unprognostic (1.23e-1)" "unprognostic (1.29e-1)" "unprognostic (1.03e-1)" "unprognostic (2.52e-1)" "unprognostic (6.15e-2)" "unprognostic (2.01e-1)" "prognostic unfavorable (4.41e-5)" "unprognostic (5.59e-2)" "unprognostic (3.75e-1)" "unprognostic (3.07e-1)" "unprognostic (1.98e-3)" 5.5 2.9 7.5 2.0 23.4 4.3 6.7 18.9 13.0 12.9 0.7 4.2 1.7 11.0 3.8 6.0 5.3 1.9 9.2 10.0 10.5 3.6 5.6 6.1 1.8 22.3 20.3 2.2 4.3 5.5 5.7 3.9 21.3 7.5 2.3 3.2 4.6 4.1 8.9 11.2 2.6 7.5 11.3 1.6 2.6 11.8 20.6 2.6 3.0 8.4 2.5 7.5 7.9 31.2 12.0 12.4 3.5 4.9 6.2 4.8 3.3 4.1 3.7 5.1 6.1 7.9 7.1 4.0 4.2 5.1 8.3 15.2 8.7 15.9 8.4 2.9 3.5 1.6 7.4 16.7 7.8 4.2 4.3 4.1 13.5 9.5 21.8 1.9 9.3 3.9 4.9 12.0 7.1 8.0 2.0 3.5 6.9 3.9 3.8 9.9 9.8 7.9 7.7 17.5 9.3 6.0 6.3 12.4 3.6 3.9 5.0 9.2 5.5 10.3 7.6 5.3 11.2 3.9 7.0 4.2 7.4 5.5 4.2 0.0 0.1 0.1 0.1 0.0 0.3 0.0 0.1 0.2 0.1 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.2 0.0 7.5 23.4 18.9 13.0 10.0 10.5 22.3 20.3 21.3 11.3 20.6 31.2 25.9 6.4 3.7 11.1 2.2 66.8 62.7 35.5 44.9 13.7 7.6 19.8 13.6 7.2 10.9 5.5 2.1 13.8 3.6 2.7 0.0 7.0 4.8 20.6 12.8 17.6 4.8 8.2 59.2 8.6 7.5 6.9 2.0 13.2 1.3 23.7 7.5 27.7 4.7 0.0 49.6 3.5 12.2 3.5 10.8 10.4 7.8 5.0 7.2 32.8 3.1 4.0 3.1 31.7 198.7 7.9 2.0 4.5 2.8 32.0 1.5 11.6 17.6 8.1 19.7 8.8 11.2 24.2 57.1 17.4 26.6 7.5 2.9 4.4 6.4 23.9 USP32 "NY-REN-60, USP10" ENSG00000170832 "Ubiquitin specific peptidase 32" Q8NFA0 17 60177327-60422470 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 102.1" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 241.8;Inhibitory neurons: 113.1;Oligodendrocytes: 268.9;Rod photoreceptor cells: 136.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "plasmacytoid DC: 59.2" "Group enriched" "Detected in all" 10 "dendritic cells: 59.2;granulocytes: 29.4" "Cell line enhanced" "Detected in all" "MCF7: 171.4" "Low region specificity" "Detected in all" HPA044365 Approved Approved "Golgi apparatus,Cytosol" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 77: Retina - Visual perception" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 9: Photoreceptor cells - Phototransduction" "Golgi apparatus" Cytosol "HPA044365: AB_2678914" "unprognostic (4.10e-2)" "unprognostic (3.38e-2)" "unprognostic (3.57e-2)" "prognostic unfavorable (1.50e-4)" "unprognostic (2.15e-1)" "unprognostic (4.33e-2)" "unprognostic (1.90e-3)" "unprognostic (2.33e-2)" "unprognostic (2.24e-1)" "unprognostic (3.93e-1)" "unprognostic (6.49e-2)" "unprognostic (2.78e-1)" "unprognostic (2.82e-1)" "unprognostic (1.97e-1)" "unprognostic (7.23e-2)" "unprognostic (8.35e-2)" "unprognostic (4.16e-2)" 16.1 21.8 13.6 15.0 27.8 32.1 14.1 23.2 23.6 12.4 25.2 13.0 9.5 10.3 6.8 21.7 10.7 11.8 17.4 14.3 22.8 20.2 26.6 20.7 10.5 22.2 25.0 10.0 12.5 19.2 11.9 13.2 24.8 10.8 11.4 58.8 12.9 11.2 40.8 21.0 10.5 13.7 18.1 18.5 12.2 102.1 22.3 14.4 20.6 29.2 11.6 13.1 14.7 44.4 32.6 38.2 19.0 30.8 44.8 45.3 17.2 26.4 41.9 34.5 45.8 18.6 20.0 19.4 21.5 50.0 56.1 16.3 33.1 36.9 61.5 16.8 13.9 39.7 31.8 19.5 44.1 31.7 33.6 39.6 24.6 49.9 45.2 33.5 38.6 24.4 42.9 17.1 41.1 171.4 32.3 21.3 21.7 29.6 18.8 15.8 51.6 11.5 33.1 24.5 13.1 19.1 22.9 6.0 33.8 32.1 27.4 41.3 32.6 49.7 54.9 33.1 23.5 16.2 37.4 19.6 24.6 23.6 33.4 14.5 4.3 16.5 2.0 3.7 1.4 3.0 1.4 1.7 8.5 2.2 1.0 1.9 29.4 1.3 4.6 59.2 2.6 2.1 13.6 27.8 23.2 23.6 14.3 22.8 22.2 25.0 24.8 18.1 22.3 44.4 8.0 6.4 16.4 58.8 12.5 26.9 13.3 5.8 11.4 17.3 9.2 7.6 8.2 10.0 10.1 5.5 241.8 5.1 12.6 8.5 3.9 11.3 95.0 9.0 9.9 9.8 8.3 44.2 92.3 7.5 8.4 12.6 15.8 11.6 11.4 18.5 12.5 12.0 18.5 13.5 113.1 5.6 6.1 29.7 41.3 33.3 13.1 25.1 5.4 101.2 28.0 10.4 24.7 70.4 268.9 9.6 11.4 5.7 8.3 10.3 7.4 4.6 7.0 136.4 26.3 11.9 9.1 92.7 14.9 11.2 21.9 4.9 10.9 8.5 5.5 8.2 USP33 "KIAA1097, VDU1" ENSG00000077254 "Ubiquitin specific peptidase 33" Q8TEY7 1 77695987-77759852 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Endocytosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Inhibitory neurons: 159.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005719 Uncertain Supported "Nucleoplasm,Golgi apparatus" NA NA "Cluster 42: Non-specific - Transcription" "Cluster 6: Brain - Smell perception" "Cluster 36: HEL - Hemostasis" "Cluster 50: Fibroblasts - ECM organization" "Nucleoplasm, Golgi apparatus" "HPA005719: AB_10601708" "unprognostic (2.31e-3)" "unprognostic (2.73e-2)" "unprognostic (1.04e-2)" "unprognostic (2.36e-1)" "unprognostic (9.19e-3)" "unprognostic (1.88e-3)" "unprognostic (1.22e-2)" "unprognostic (6.06e-2)" "unprognostic (2.48e-1)" "unprognostic (2.25e-1)" "unprognostic (2.67e-1)" "unprognostic (3.59e-1)" "unprognostic (5.36e-3)" "unprognostic (4.89e-2)" "unprognostic (5.76e-2)" "unprognostic (2.19e-1)" "unprognostic (2.02e-2)" 40.7 31.2 31.5 24.6 40.4 34.5 34.3 52.0 49.7 24.2 37.3 24.3 25.4 28.0 26.8 21.6 22.5 26.3 21.7 35.4 31.8 31.1 25.4 26.2 28.1 28.6 24.9 29.3 19.5 35.0 20.9 28.0 30.8 28.8 25.2 49.1 25.2 22.9 18.0 24.3 26.9 24.1 22.3 26.0 24.4 25.4 28.6 27.1 30.4 20.7 26.0 22.9 20.0 55.5 42.4 18.8 64.1 44.2 90.0 78.3 54.8 45.3 42.9 54.0 60.1 25.4 35.5 31.4 41.2 44.3 88.2 32.1 47.4 31.1 65.7 28.8 36.6 111.1 44.6 22.2 56.0 37.8 26.8 58.3 23.9 52.4 37.9 51.9 48.7 28.0 43.9 26.3 41.2 16.1 34.9 38.0 62.2 32.6 37.2 33.0 67.7 22.2 51.0 41.1 53.8 41.2 31.9 41.5 64.2 54.3 23.1 41.2 41.2 49.4 34.4 50.1 43.2 21.0 28.4 30.4 37.3 44.5 25.4 67.3 22.5 31.8 21.0 22.6 21.7 20.5 20.6 21.7 17.5 22.3 24.5 21.9 30.5 19.2 30.1 18.4 20.7 16.7 31.5 40.4 52.0 49.7 35.4 31.8 28.6 24.9 30.8 22.3 28.6 55.5 40.2 44.8 40.9 66.3 35.1 17.2 18.8 21.2 32.5 56.7 25.7 22.1 39.9 22.8 25.5 35.0 58.4 25.1 48.8 35.9 9.8 20.8 4.3 54.8 37.8 31.8 35.5 50.9 149.3 15.4 19.0 39.6 43.3 54.6 23.4 43.1 28.2 23.1 19.0 62.2 159.0 28.6 22.4 30.8 20.7 5.5 35.8 35.1 23.2 75.9 38.7 31.4 37.0 98.0 138.5 19.6 27.8 32.0 42.4 22.9 33.2 25.6 37.3 44.5 19.7 34.9 35.6 39.8 30.1 28.4 16.3 11.9 41.0 39.2 24.8 21.8 USP34 "KIAA0570, KIAA0729" ENSG00000115464 "Ubiquitin specific peptidase 34" Q70CQ2 2 61187463-61471087 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 310.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA025815, HPA070764" Uncertain Approved Nucleoplasm NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 52: Non-specific - Transcription" Nucleoplasm "HPA025815: AB_1858681, HPA070764: AB_2686308" "unprognostic (4.04e-2)" "unprognostic (8.21e-3)" "unprognostic (5.08e-2)" "unprognostic (3.14e-2)" "unprognostic (4.13e-2)" "unprognostic (1.43e-2)" "unprognostic (1.04e-1)" "unprognostic (2.66e-1)" "unprognostic (1.47e-1)" "unprognostic (2.90e-2)" "unprognostic (8.91e-2)" "unprognostic (4.62e-2)" "unprognostic (9.58e-2)" "unprognostic (1.66e-1)" "unprognostic (2.53e-1)" "unprognostic (6.34e-2)" "unprognostic (7.01e-2)" 32.2 36.0 49.9 21.7 53.9 37.7 35.6 57.7 58.3 36.1 59.9 47.0 14.8 38.4 54.4 35.8 33.3 21.1 33.7 49.7 53.5 43.3 34.8 36.4 44.1 52.1 51.8 43.4 32.4 35.1 45.0 17.4 52.3 38.6 26.8 77.5 27.2 32.4 53.9 41.4 40.8 27.9 50.3 45.8 36.3 45.1 54.5 47.8 32.2 36.8 45.1 36.9 32.8 56.8 43.6 29.9 38.9 40.3 71.8 48.1 32.4 26.3 37.1 23.0 21.7 43.0 16.3 102.2 27.0 56.9 24.3 23.4 30.9 34.4 42.6 36.7 24.4 61.6 29.5 69.6 60.2 46.1 37.8 52.9 43.6 41.9 62.1 55.7 49.0 28.8 42.7 32.2 51.5 40.6 30.6 66.6 26.3 43.9 23.9 32.4 46.5 27.7 67.9 52.2 31.9 34.0 40.5 30.1 48.3 49.4 16.0 33.2 43.6 36.1 48.2 21.5 34.7 37.0 19.7 103.6 33.8 42.5 31.7 2.1 1.2 1.6 3.8 1.1 3.5 2.6 2.6 2.9 1.0 3.1 2.9 3.9 1.8 3.1 2.8 3.2 2.5 1.4 49.9 53.9 57.7 58.3 49.7 53.5 52.1 51.8 52.3 50.3 54.5 56.8 64.5 64.1 68.3 193.6 82.8 61.1 54.2 40.3 46.7 139.7 54.0 46.6 46.0 48.6 54.6 33.1 250.2 33.5 87.3 46.0 9.8 41.4 133.5 59.9 66.9 59.3 48.6 53.2 256.6 33.6 23.8 53.0 73.9 70.6 32.3 78.0 31.8 38.9 21.6 107.7 240.4 37.8 59.0 45.4 48.6 138.0 56.8 56.0 40.9 212.7 55.2 60.0 87.6 232.2 310.0 49.9 41.1 67.0 69.9 79.9 38.3 23.4 44.1 178.1 26.3 78.2 63.9 95.8 115.9 53.1 61.4 53.4 70.5 74.7 35.6 69.9 USP35 KIAA1372 ENSG00000118369 "Ubiquitin specific peptidase 35" Q9P2H5 11 78188812-78215232 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 9 "Early spermatids: 39.1;Granulosa cells: 30.8;Late spermatids: 121.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA055213, HPA058592" Uncertain Approved "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 31: Spermatids - Spermatogenesis" "Nucleoli fibrillar center" Nucleoplasm "HPA055213: AB_2682740, HPA058592: AB_2683766" "unprognostic (6.69e-2)" "unprognostic (1.17e-2)" "unprognostic (1.69e-1)" "unprognostic (6.87e-3)" "unprognostic (3.38e-2)" "unprognostic (1.08e-2)" "unprognostic (2.00e-1)" "unprognostic (1.46e-1)" "unprognostic (3.57e-2)" "unprognostic (3.84e-3)" "unprognostic (1.03e-2)" "unprognostic (3.11e-2)" "unprognostic (1.29e-3)" "unprognostic (2.93e-1)" "unprognostic (1.31e-1)" "unprognostic (4.38e-2)" "unprognostic (1.49e-2)" 6.1 19.8 8.0 3.6 7.4 2.5 5.1 5.1 8.0 9.2 7.4 7.6 3.5 6.7 3.2 6.0 6.4 3.5 10.2 8.3 7.1 6.2 16.8 7.0 3.3 9.0 8.2 7.4 5.9 12.4 13.4 4.7 9.4 5.9 1.9 2.1 3.9 3.2 4.1 3.0 4.5 4.7 3.9 4.9 4.6 4.5 8.3 6.2 8.7 4.0 2.6 6.6 7.7 6.4 2.2 3.3 5.7 6.1 9.7 8.7 3.9 5.0 5.8 5.8 4.0 8.4 4.7 1.7 5.0 9.5 6.2 5.8 3.8 7.8 3.4 12.8 2.0 2.9 9.8 5.0 7.4 1.8 8.3 7.4 5.1 12.1 3.5 11.4 7.2 6.5 4.1 4.2 4.6 2.0 4.7 7.6 1.7 6.2 5.3 2.9 5.2 2.0 4.5 4.1 2.8 5.9 3.9 5.1 1.9 8.1 4.3 1.6 8.9 10.6 5.9 12.8 2.7 5.7 2.0 2.7 3.1 2.0 6.3 0.0 0.0 0.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.0 7.4 5.1 8.0 8.3 7.1 9.0 8.2 9.4 3.9 8.3 6.4 1.3 0.0 1.8 5.9 1.2 0.8 0.2 0.7 3.4 0.8 1.0 0.6 3.5 0.0 0.3 0.0 6.2 0.7 1.0 1.2 0.0 1.1 39.1 1.3 2.7 1.9 0.0 0.4 5.2 2.0 1.6 2.0 5.1 1.2 0.0 30.8 1.4 2.7 1.6 0.0 4.8 0.9 0.0 0.6 0.8 121.6 1.5 1.4 1.8 2.8 2.7 0.4 0.0 3.5 2.8 2.0 0.1 3.0 0.8 0.3 0.8 1.0 0.5 0.6 6.6 0.7 1.3 1.2 2.4 4.1 1.0 0.3 2.9 2.1 1.3 0.2 USP36 "FLJ12851, KIAA1453" ENSG00000055483 "Ubiquitin specific peptidase 36" Q9P275 17 78787381-78841441 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012082, HPA012395, HPA052860" Uncertain Supported Enhanced "Nucleoli,Nucleoli rim,Nuclear speckles" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 50: Non-specific - Ribosome" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 24: Non-specific - Transcription regulation" "Nucleoli, Nucleoli rim" "Nuclear speckles" "HPA012082: AB_1858682, HPA012395: , HPA052860: AB_2681974" "unprognostic (1.94e-2)" "unprognostic (2.80e-2)" "unprognostic (1.07e-1)" "prognostic unfavorable (5.18e-5)" "unprognostic (9.35e-2)" "unprognostic (1.98e-1)" "unprognostic (2.50e-3)" "unprognostic (1.35e-1)" "unprognostic (2.04e-1)" "unprognostic (1.33e-1)" "unprognostic (1.68e-2)" "unprognostic (2.78e-2)" "unprognostic (1.31e-2)" "unprognostic (1.45e-1)" "unprognostic (1.81e-1)" "unprognostic (4.03e-3)" "unprognostic (1.78e-1)" 43.9 37.9 20.0 21.5 21.9 46.6 32.9 29.3 23.9 32.6 27.5 31.2 13.4 26.8 22.9 25.0 34.2 18.7 30.2 21.4 20.6 34.4 30.3 36.1 20.6 22.6 21.3 67.4 44.5 18.1 50.3 26.0 21.5 36.2 15.8 26.3 24.9 13.1 30.3 40.4 26.6 16.3 19.4 30.7 31.2 22.2 21.2 15.1 31.6 11.7 20.5 29.3 29.8 30.1 42.7 50.3 14.6 26.9 30.5 33.7 27.8 34.1 34.5 32.1 21.5 49.2 21.0 54.0 16.9 30.6 34.8 30.6 34.5 25.4 57.0 13.0 52.1 49.4 81.0 51.9 31.3 54.7 26.0 29.5 41.0 45.8 101.6 24.7 28.3 24.1 40.0 55.3 26.8 32.6 50.1 55.1 22.6 31.6 39.9 38.1 31.8 36.3 20.2 44.1 42.8 25.8 24.5 112.5 63.7 31.3 29.2 34.4 24.3 75.2 35.3 44.3 61.1 40.7 17.4 66.1 29.6 41.9 24.0 10.1 3.0 2.4 5.5 4.2 6.5 5.1 5.2 4.8 1.8 4.7 5.7 5.6 4.3 4.5 2.7 9.7 3.8 1.9 20.0 21.9 29.3 23.9 21.4 20.6 22.6 21.3 21.5 19.4 21.2 30.1 27.4 12.8 37.4 23.5 55.9 51.7 28.4 8.2 40.9 33.2 18.1 16.9 14.1 18.6 18.8 14.7 33.3 8.3 66.3 14.4 5.9 10.2 20.7 22.3 24.0 28.4 18.5 14.7 19.0 9.6 11.3 26.6 25.0 42.7 20.3 12.8 12.1 16.5 43.3 26.9 22.5 18.6 10.2 24.5 72.8 8.5 11.8 49.4 30.2 10.3 14.9 13.2 16.5 13.6 19.8 13.2 8.4 12.4 57.1 32.4 7.3 5.0 11.1 32.1 6.6 22.1 23.1 18.4 16.5 24.4 43.3 12.9 73.6 13.1 18.6 22.2 USP37 KIAA1594 ENSG00000135913 "Ubiquitin specific peptidase 37" Q86T82 2 218450251-218568351 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 119.4;Late spermatids: 145.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045160 Approved Approved Nucleoplasm,Nucleoli NA Yes "Cluster 44: Non-specific - Transcription" "Cluster 6: Brain - Smell perception" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Nucleoli" "HPA045160: AB_10795620" "unprognostic (7.00e-2)" "unprognostic (2.29e-1)" "unprognostic (8.83e-2)" "unprognostic (9.19e-4)" "unprognostic (1.83e-1)" "prognostic favorable (2.85e-4)" "unprognostic (2.18e-2)" "unprognostic (1.14e-1)" "unprognostic (9.66e-3)" "unprognostic (1.17e-1)" "unprognostic (3.78e-3)" "unprognostic (1.11e-1)" "unprognostic (3.82e-2)" "unprognostic (3.26e-1)" "unprognostic (2.87e-1)" "unprognostic (6.69e-2)" "unprognostic (6.41e-3)" 2.7 4.1 3.5 4.4 4.7 11.8 4.7 8.5 4.9 3.6 1.9 3.0 2.9 4.2 7.5 3.9 3.3 3.5 2.3 3.3 4.0 2.9 3.8 3.0 6.0 3.8 4.0 5.9 3.0 4.0 1.4 4.0 4.0 3.6 3.5 9.1 3.9 3.0 2.9 3.9 3.3 3.2 2.5 3.8 3.4 12.7 3.4 6.3 5.0 4.2 4.9 3.6 2.2 8.3 9.6 6.9 14.2 11.0 3.6 4.4 12.1 7.1 5.1 12.2 13.6 13.1 7.4 8.7 7.5 5.6 9.3 8.9 15.7 8.0 13.4 12.0 8.3 23.5 13.6 8.7 4.1 15.6 11.3 2.4 4.7 12.9 9.2 4.5 5.3 15.0 17.3 16.2 7.8 7.2 20.1 10.6 12.2 6.2 5.9 16.0 21.3 8.0 4.2 11.2 15.5 8.4 11.5 5.6 7.2 13.6 6.4 10.8 6.8 13.7 12.0 7.7 9.5 11.0 10.4 17.6 7.4 11.2 9.5 4.2 2.0 3.8 3.1 2.3 3.2 2.5 2.6 2.7 2.1 3.2 4.0 2.6 1.6 3.2 2.2 2.9 3.6 1.2 3.5 4.7 8.5 4.9 3.3 4.0 3.8 4.0 4.0 2.5 3.4 8.3 12.8 0.0 11.0 34.3 16.5 19.5 7.0 7.1 22.2 14.7 14.4 10.2 4.9 4.3 9.6 7.3 27.1 8.4 13.4 5.5 0.0 5.8 119.4 13.3 11.8 14.2 10.3 16.6 47.4 2.3 6.6 13.2 9.2 16.4 5.1 16.2 12.5 11.0 7.8 15.2 40.0 8.9 4.1 8.5 22.9 145.5 9.9 17.2 21.4 27.2 10.2 9.1 10.3 35.2 60.5 4.9 7.4 9.8 14.6 12.1 7.1 4.2 11.1 19.9 6.6 12.7 21.6 60.8 31.4 13.6 20.6 7.3 19.7 10.9 7.6 7.1 USP38 "HP43.8KD, KIAA1891" ENSG00000170185 "Ubiquitin specific peptidase 38" Q8NB14 4 143184917-143223874 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 36.6" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-266/84: 65.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036990, HPA047948" Uncertain Approved Nucleoplasm,Centrosome,Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 16: U-266 - Nucleosome" "Cluster 44: Endometrium - Transcription" Nucleoplasm "Centrosome, Cytosol" "HPA036990: AB_2675419, HPA047948: AB_2680220" "unprognostic (5.01e-2)" "unprognostic (2.45e-1)" "unprognostic (2.04e-3)" "unprognostic (2.99e-2)" "unprognostic (1.87e-1)" "unprognostic (2.61e-2)" "unprognostic (1.67e-1)" "unprognostic (7.49e-2)" "unprognostic (3.66e-2)" "unprognostic (3.97e-2)" "unprognostic (8.03e-2)" "unprognostic (7.72e-3)" "prognostic favorable (1.20e-4)" "unprognostic (3.15e-1)" "unprognostic (1.26e-1)" "unprognostic (1.29e-1)" "unprognostic (1.02e-1)" 6.5 4.4 2.5 6.2 4.3 21.6 4.6 4.3 2.9 6.2 4.3 8.0 7.9 5.5 2.3 7.0 4.3 5.2 6.8 2.2 2.4 7.0 13.2 6.3 6.4 5.9 3.8 3.7 8.2 7.7 3.3 8.1 4.9 5.5 5.7 4.5 5.8 5.6 36.6 5.9 7.2 5.7 4.9 7.4 6.3 6.8 3.2 9.3 7.4 21.3 5.8 6.8 3.9 6.8 8.5 7.9 6.6 11.3 8.4 8.2 5.1 13.0 12.5 11.8 10.1 23.1 11.7 10.5 9.2 11.5 7.8 6.5 15.9 13.5 10.2 26.0 10.5 9.7 8.5 4.7 11.3 19.4 9.4 10.2 11.1 12.0 9.5 8.3 12.2 11.9 21.5 31.5 7.9 13.3 25.6 3.7 6.1 17.7 15.3 16.7 10.2 10.1 7.2 9.2 13.8 12.3 10.5 17.3 10.9 4.9 10.8 7.6 14.6 10.8 9.1 9.6 14.1 35.7 65.3 18.6 10.9 14.4 9.3 13.4 4.5 9.7 5.7 4.6 7.0 4.6 4.9 4.9 6.6 4.5 4.8 4.2 4.3 10.1 4.9 2.7 7.9 4.3 2.5 4.3 4.3 2.9 2.2 2.4 5.9 3.8 4.9 4.9 3.2 6.8 21.5 22.4 19.8 13.7 19.5 53.5 21.0 6.2 25.6 7.4 20.8 13.7 18.4 10.0 12.2 0.0 12.5 12.8 22.2 35.5 1.9 8.3 36.4 20.7 26.1 15.3 30.6 31.5 19.6 7.7 7.1 13.4 26.0 52.1 3.8 9.9 17.9 38.4 10.6 8.4 15.9 20.2 4.1 17.0 16.6 20.3 6.8 21.9 12.4 9.4 10.1 15.1 12.3 18.6 22.8 10.2 13.4 9.4 38.6 16.8 17.0 18.5 10.9 8.9 13.1 15.0 14.1 11.3 4.7 31.5 59.1 26.7 23.2 11.0 17.6 45.4 USP39 "CGI-21, SAD1, SNRNP65" ENSG00000168883 "Ubiquitin specific peptidase 39" Q53GS9 2 85602856-85649283 "Enzymes, Predicted intracellular proteins" "Cell cycle, Cell division, mRNA processing, mRNA splicing" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034823, HPA077350" Supported Supported Supported Nucleoplasm NA NA "Cluster 44: Non-specific - Transcription" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Nucleoplasm "HPA034823: AB_10602488, HPA077350: " "unprognostic (1.10e-2)" "unprognostic (3.31e-3)" "unprognostic (1.83e-1)" "prognostic unfavorable (5.52e-4)" "unprognostic (8.46e-3)" "unprognostic (3.67e-2)" "prognostic unfavorable (2.84e-6)" "unprognostic (1.10e-2)" "unprognostic (1.69e-1)" "unprognostic (1.89e-1)" "unprognostic (5.17e-3)" "unprognostic (3.14e-2)" "prognostic unfavorable (4.05e-7)" "unprognostic (3.95e-3)" "unprognostic (2.25e-1)" "unprognostic (2.52e-2)" "unprognostic (2.52e-1)" 22.6 16.1 18.1 19.8 18.7 40.8 21.3 19.0 20.6 22.2 22.7 24.2 17.1 23.5 26.1 22.7 19.5 12.7 22.7 17.9 19.5 21.7 18.5 21.4 26.5 18.9 18.4 20.1 17.2 21.8 14.3 26.9 18.9 18.7 22.7 22.0 19.0 21.2 55.2 23.8 19.5 21.3 18.9 20.9 20.6 15.6 18.8 41.0 19.8 42.6 32.2 24.7 20.6 19.8 71.0 70.0 70.0 77.5 49.7 38.7 79.5 59.2 54.6 84.1 74.5 113.9 49.8 83.0 53.4 54.6 62.3 50.6 135.7 62.5 105.8 83.9 86.4 103.4 39.1 100.6 49.0 127.4 67.5 27.9 49.3 65.1 57.8 39.3 68.1 85.3 129.8 47.2 62.8 81.4 125.2 94.8 92.8 84.9 64.2 114.1 150.0 63.1 45.0 53.8 65.1 53.7 36.4 58.9 51.4 56.7 39.5 60.5 43.9 51.7 65.0 62.7 97.2 42.0 83.0 87.7 44.9 130.5 63.6 51.1 35.8 44.5 40.2 42.4 46.6 34.7 41.8 41.7 40.6 37.0 40.4 37.0 23.1 40.4 41.6 32.0 53.4 43.6 18.1 18.7 19.0 20.6 17.9 19.5 18.9 18.4 18.9 18.9 18.8 19.8 18.4 19.2 25.2 19.9 17.5 20.5 16.7 17.9 22.2 8.5 14.1 14.0 17.3 11.5 19.9 12.9 8.4 54.1 17.8 14.8 21.5 21.1 26.1 9.8 15.4 17.1 12.1 18.3 13.9 18.8 31.8 17.1 9.7 11.7 17.1 16.3 17.5 14.2 25.6 5.0 18.2 13.4 24.4 11.9 14.7 13.0 19.3 17.6 19.6 17.8 26.4 15.3 12.3 16.1 33.1 19.2 8.5 18.8 14.0 16.0 11.2 14.6 15.6 11.6 0.0 13.0 17.7 19.5 17.1 15.5 16.2 35.7 21.3 12.7 15.7 16.3 USP4 "UNP, Unph" ENSG00000114316 "Ubiquitin specific peptidase 4" Q13107 3 49277144-49340712 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 131.8;Late spermatids: 104.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA018499 Approved Approved "Plasma membrane,Cytosol" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 30: Epithelial cell lines - Translation" "Cluster 34: Spermatids - Unknown function" "Plasma membrane, Cytosol" "HPA018499: AB_1858689" "unprognostic (2.34e-3)" "unprognostic (1.52e-1)" "unprognostic (2.22e-3)" "unprognostic (6.12e-2)" "unprognostic (3.51e-1)" "unprognostic (4.33e-2)" "unprognostic (9.42e-2)" "prognostic favorable (4.46e-5)" "unprognostic (3.54e-1)" "unprognostic (9.07e-3)" "unprognostic (2.78e-2)" "unprognostic (1.70e-3)" "prognostic favorable (4.29e-5)" "unprognostic (7.30e-2)" "unprognostic (1.00e-1)" "unprognostic (1.18e-2)" "unprognostic (1.65e-2)" 25.2 20.3 24.2 26.5 26.3 53.7 24.9 24.5 28.2 27.7 27.1 25.4 18.3 24.4 21.6 26.0 22.4 18.3 26.5 23.7 23.4 21.8 20.2 29.5 30.9 23.9 24.4 24.5 19.0 24.1 16.4 23.3 23.9 23.7 23.4 26.9 21.0 21.7 31.6 31.4 22.5 24.0 22.4 33.7 20.2 28.0 24.8 37.0 23.0 28.8 33.7 25.8 25.0 24.5 14.2 15.8 21.6 28.8 38.7 40.1 14.7 36.4 32.9 46.7 41.3 16.8 34.8 27.1 14.4 53.9 27.4 18.9 28.6 52.6 42.5 42.1 8.4 60.3 31.9 19.6 57.0 32.5 34.0 42.8 23.3 51.0 41.5 34.3 55.0 29.9 21.6 41.6 42.1 24.5 38.3 55.8 18.7 17.7 26.9 15.6 13.3 23.9 37.5 29.2 17.5 24.0 27.2 19.3 14.0 21.6 13.5 51.2 50.1 31.1 17.2 39.6 22.5 33.6 17.3 38.6 28.6 50.1 36.5 70.1 83.6 94.8 48.1 69.2 53.7 51.0 50.2 48.9 74.6 41.4 47.7 42.2 179.2 72.4 81.2 28.4 59.7 78.0 24.2 26.3 24.5 28.2 23.7 23.4 23.9 24.4 23.9 22.4 24.8 24.5 24.3 41.7 25.1 28.1 24.7 18.7 17.9 17.2 22.2 17.5 10.9 10.3 17.9 10.0 23.2 20.2 20.9 22.7 27.9 13.6 21.5 16.5 131.8 17.3 18.3 22.1 10.7 31.6 30.8 13.6 14.3 17.9 27.5 21.1 33.6 21.4 17.5 14.6 24.0 11.8 26.4 13.8 16.2 38.6 21.0 104.9 15.5 34.2 16.0 16.9 36.0 13.9 23.7 25.6 20.2 18.9 7.6 19.2 29.2 17.6 14.5 13.4 28.6 20.5 13.1 18.4 17.0 35.3 14.5 17.9 18.5 24.2 29.4 17.0 13.9 14.5 USP40 FLJ10785 ENSG00000085982 "Ubiquitin specific peptidase 40" Q9NVE5 2 233475520-233566782 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 79.3;Oligodendrocytes: 127.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005821 Uncertain Approved "Vesicles,Focal adhesion sites" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 68: Epididymis - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 64: Astrocytes - Nervous system maintenance" Vesicles "Focal adhesion sites" "HPA005821: AB_1080526" "unprognostic (2.19e-1)" "unprognostic (1.04e-1)" "unprognostic (1.13e-1)" "unprognostic (1.33e-1)" "unprognostic (3.70e-1)" "unprognostic (2.15e-1)" "unprognostic (5.30e-2)" "unprognostic (2.25e-1)" "unprognostic (1.80e-2)" "unprognostic (1.18e-1)" "unprognostic (1.96e-1)" "unprognostic (1.26e-1)" "unprognostic (2.22e-1)" "unprognostic (1.45e-1)" "unprognostic (4.09e-2)" "unprognostic (1.90e-2)" "unprognostic (2.53e-2)" 11.8 12.0 10.4 7.5 17.0 3.4 13.9 12.8 11.4 10.0 16.5 9.4 10.5 10.6 24.0 10.4 11.5 11.6 8.2 10.2 12.0 14.2 13.2 12.5 7.2 19.4 14.2 15.9 14.0 16.8 8.5 12.4 19.0 13.5 9.5 14.2 12.9 10.4 9.6 19.7 10.1 8.5 12.3 9.9 13.1 14.7 16.2 10.1 16.4 7.6 7.8 9.6 7.5 25.4 17.3 19.9 17.6 12.0 25.2 23.0 15.7 16.4 12.4 14.7 16.0 14.3 20.2 0.4 4.7 26.4 38.6 30.3 13.3 29.7 20.6 0.0 9.0 13.3 17.4 24.3 22.3 5.8 8.9 22.2 21.1 22.2 30.9 26.2 17.3 8.1 22.0 3.2 21.4 14.0 6.2 8.5 7.9 17.8 16.0 0.0 36.3 8.1 17.9 27.6 9.6 10.3 13.5 13.5 16.9 12.9 15.4 12.9 17.3 20.9 13.1 8.9 20.6 6.0 4.9 0.8 27.1 10.2 18.6 0.0 1.0 0.0 0.5 1.1 0.2 0.4 0.5 0.4 1.5 0.7 0.7 0.7 0.1 0.5 0.9 1.9 0.8 0.5 10.4 17.0 12.8 11.4 10.2 12.0 19.4 14.2 19.0 12.3 16.2 25.4 11.8 32.1 35.5 79.3 7.9 7.4 9.1 13.6 15.4 18.1 17.0 14.7 10.7 10.0 19.9 16.5 25.0 21.2 6.7 9.9 7.9 9.4 8.4 19.8 18.3 11.1 15.0 5.7 25.9 12.6 10.6 11.9 21.4 21.3 9.5 23.4 12.8 25.4 8.2 23.5 38.2 10.9 4.1 11.6 3.6 10.7 6.8 9.1 3.6 40.3 5.9 11.9 4.1 48.2 127.7 10.5 12.6 8.2 10.9 12.9 13.9 14.6 21.0 19.4 13.1 17.5 10.6 30.2 20.9 17.2 10.5 15.7 5.5 21.1 12.1 10.0 USP42 FLJ12697 ENSG00000106346 "Ubiquitin specific peptidase 42" Q9H9J4 7 6104884-6161564 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Differentiation, Spermatogenesis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 89.1;Spermatocytes: 72.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006939, HPA064800" Approved Nucleoplasm,Nucleoli NA NA "Cluster 10: Basophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 59: Non-specific - Transcription" Nucleoplasm Nucleoli "HPA006939: , HPA064800: AB_2685355" "unprognostic (1.48e-2)" "unprognostic (1.47e-1)" "unprognostic (2.59e-1)" "unprognostic (1.69e-1)" "unprognostic (1.30e-2)" "unprognostic (1.53e-1)" "unprognostic (1.19e-2)" "unprognostic (3.32e-1)" "unprognostic (1.05e-1)" "unprognostic (2.82e-1)" "unprognostic (6.21e-3)" "unprognostic (2.47e-2)" "unprognostic (3.17e-3)" "unprognostic (3.14e-2)" "unprognostic (3.06e-2)" "unprognostic (2.19e-2)" "unprognostic (2.66e-1)" 3.8 3.0 3.1 3.2 3.0 13.4 3.9 5.8 4.4 4.3 2.4 4.5 4.5 4.9 3.6 3.7 4.3 3.4 3.2 3.0 3.0 3.9 4.0 4.1 3.8 2.8 3.1 4.9 3.8 4.7 3.8 3.3 2.7 3.8 3.4 5.8 3.5 3.1 4.3 5.4 4.3 4.1 2.9 4.4 3.6 15.2 3.2 5.7 4.0 3.4 3.2 4.0 3.8 3.2 10.2 7.4 13.1 12.9 7.4 5.5 9.0 5.4 6.9 6.2 6.1 5.3 5.2 12.0 3.4 6.7 9.2 9.3 11.1 5.9 6.7 2.9 8.6 5.6 6.1 5.5 6.3 13.0 6.1 6.4 6.8 6.7 8.5 5.7 7.7 10.0 21.7 7.9 4.1 9.1 7.9 14.6 14.8 5.2 5.6 14.9 10.2 8.2 5.9 5.3 10.0 17.7 6.9 14.0 4.3 12.0 6.5 6.6 6.5 5.5 20.5 7.0 6.5 7.0 6.3 10.3 4.6 7.8 11.0 0.6 0.3 0.9 0.5 0.6 0.7 0.4 0.6 0.3 0.3 0.2 0.4 1.0 0.3 0.5 0.3 0.6 0.5 0.2 3.1 3.0 5.8 4.4 3.0 3.0 2.8 3.1 2.7 2.9 3.2 3.2 13.7 12.8 7.0 19.6 16.1 40.5 18.2 5.2 26.7 18.7 17.4 10.8 10.5 8.6 6.8 1.8 22.9 8.3 16.4 20.7 0.0 10.4 89.1 27.1 15.3 14.4 10.7 10.8 26.1 10.4 8.4 13.4 15.3 25.6 9.5 13.4 12.8 9.8 8.2 21.9 26.2 18.1 8.2 9.1 19.9 42.5 14.3 12.4 10.6 18.7 7.7 10.1 12.3 18.6 26.2 12.0 7.7 12.8 21.7 22.3 12.4 5.7 10.6 18.7 13.1 16.2 14.9 72.4 37.0 23.1 41.5 26.8 19.2 6.4 14.4 15.3 USP43 FLJ30626 ENSG00000154914 "Ubiquitin specific peptidase 43" Q70EL4 17 9644698-9729687 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 37.9;Excitatory neurons: 35.5;Glandular and luminal cells: 52.5;Oligodendrocyte precursor cells: 73.4;Syncytiotrophoblasts: 73.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 11.7;SK-BR-3: 8.1;T-47d: 9.9" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" "HPA023389, HPA027762, HPA027763" Uncertain Approved "Nucleoplasm,Nuclear speckles" NA NA "Cluster 29: Non-specific - Vesicular transport" "Cluster 28: BEWO - Transcription regulation" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Nuclear speckles" "HPA023389: AB_1858691, HPA027762: AB_10603001, HPA027763: " "unprognostic (1.39e-1)" "unprognostic (1.75e-2)" "unprognostic (1.07e-1)" "unprognostic (2.30e-3)" "unprognostic (1.08e-1)" "unprognostic (5.24e-2)" "unprognostic (2.04e-1)" "unprognostic (6.40e-3)" "unprognostic (2.26e-1)" "unprognostic (3.05e-3)" "unprognostic (2.41e-2)" "unprognostic (7.49e-2)" "unprognostic (5.95e-2)" "prognostic favorable (5.39e-4)" "unprognostic (3.24e-1)" "unprognostic (2.06e-1)" "unprognostic (3.28e-1)" 0.3 0.2 2.6 0.6 3.4 0.7 1.9 0.8 4.1 2.9 2.9 3.5 4.2 1.9 1.0 6.5 4.2 1.2 0.0 3.3 1.4 4.0 9.1 3.2 0.1 2.5 4.6 0.1 5.0 1.1 3.5 8.3 2.5 9.8 3.2 1.4 4.3 2.2 0.0 2.2 3.5 0.2 2.1 0.3 2.1 3.2 2.3 0.3 1.7 0.0 0.7 1.1 2.4 2.5 5.6 1.4 0.0 0.5 0.0 0.0 11.7 0.1 0.2 0.6 1.6 2.8 4.5 0.0 1.8 0.2 2.5 6.8 0.6 5.3 0.6 3.6 1.8 0.3 3.0 1.0 0.1 0.5 0.0 0.0 6.8 0.3 2.8 0.3 0.0 0.8 0.0 0.0 0.0 2.6 0.9 4.6 0.7 4.8 0.3 3.6 0.0 0.8 4.1 3.0 0.7 0.0 2.4 8.1 1.0 3.7 9.9 1.4 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.7 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.6 3.4 0.8 4.1 3.3 1.4 2.5 4.6 2.5 2.1 2.3 2.5 0.0 3.2 3.1 1.6 0.3 4.7 7.8 4.6 5.2 0.5 7.0 2.4 0.6 4.3 7.4 11.0 6.2 26.2 0.6 14.3 1.9 4.4 1.1 37.9 4.2 0.5 2.4 3.2 35.5 4.7 23.7 0.8 7.7 52.5 0.0 0.9 0.4 15.6 2.7 0.0 4.0 8.3 2.0 0.9 0.3 1.1 0.0 0.6 5.4 0.0 0.3 8.4 0.0 73.4 1.2 11.3 3.5 0.0 0.2 10.6 8.7 1.8 30.2 1.5 0.0 0.0 1.0 1.5 0.3 12.3 3.3 73.2 0.7 0.0 9.7 11.8 USP44 FLJ14528 ENSG00000136014 "Ubiquitin specific peptidase 44" Q9H0E7 12 95516560-95551476 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 7.1;testis: 24.2" "Cell type enriched" "Detected in many" 4 "Early spermatids: 482.2" "Cancer enhanced" "Detected in some" "testis cancer: 3.0" "Region enriched" "Detected in many" 6 "cerebellum: 7.1" "Immune cell enhanced" "Detected in many" "naive CD4 T-cell: 6.1" "Group enriched" "Detected in many" 41 "B-cells: 4.6;T-cells: 6.1" "Cell line enhanced" "Detected in some" "HEL: 26.4;JURKAT: 58.4;NTERA-2: 138.3" "Not detected" "Not detected" "Low region specificity" "Detected in single" HPA026543 Approved "Nucleoli fibrillar center,Microtubules" NA NA "Cluster 30: Non-specific - Translation" "Cluster 78: Testis - Spermatogenesis" "Cluster 5: NTERA-2 - Transcription" "Cluster 23: Spermatids - Flagellum & Golgi organization" "Nucleoli fibrillar center, Microtubules" "HPA026543: AB_1858692" "unprognostic (2.12e-2)" "unprognostic (1.14e-1)" "unprognostic (4.68e-2)" "unprognostic (1.01e-3)" "unprognostic (1.83e-4)" "unprognostic (7.18e-4)" "unprognostic (5.55e-2)" "unprognostic (1.85e-2)" "unprognostic (2.16e-1)" "unprognostic (3.73e-2)" "unprognostic (6.88e-2)" "unprognostic (2.97e-2)" "unprognostic (8.12e-2)" "unprognostic (1.41e-2)" "unprognostic (1.08e-1)" "unprognostic (7.41e-2)" "unprognostic (7.07e-2)" 0.7 0.6 0.6 1.0 0.8 0.3 0.9 7.1 1.0 0.9 0.0 1.2 0.3 1.3 0.7 0.4 1.2 0.8 0.5 0.6 0.5 1.4 0.1 3.9 1.1 0.8 0.9 0.9 2.3 1.7 1.3 0.1 1.0 0.7 0.4 1.7 1.1 1.6 0.2 0.3 0.8 0.9 0.7 1.5 0.6 24.2 0.5 3.6 1.3 0.3 1.2 0.5 0.5 1.2 0.2 0.4 11.4 0.0 0.1 0.1 0.4 1.1 3.3 1.4 0.5 0.0 0.1 0.1 3.4 0.0 0.0 0.1 0.0 0.0 1.9 0.0 5.8 26.4 0.0 0.0 5.8 10.8 0.5 0.1 0.0 0.8 0.0 0.6 0.6 58.4 4.3 0.0 0.0 0.0 13.9 0.1 138.3 0.0 0.0 0.0 0.0 0.0 2.4 0.8 8.8 5.9 0.0 0.0 0.1 13.2 0.1 0.9 0.0 0.1 0.0 0.0 0.0 0.0 0.3 4.6 0.0 1.0 0.3 0.0 0.0 0.0 1.1 0.0 2.4 4.6 1.7 1.5 0.0 3.7 6.1 4.0 0.1 0.1 0.0 0.0 0.2 1.0 0.6 0.8 7.1 1.0 0.6 0.5 0.8 0.9 1.0 0.7 0.5 1.2 1.9 12.8 31.0 1.3 5.7 1.0 3.4 0.3 4.6 8.6 1.5 3.2 1.8 0.0 3.8 7.3 6.2 2.8 0.6 0.1 0.0 4.4 482.2 0.9 2.2 2.5 0.0 0.4 5.1 3.1 0.5 3.5 1.1 1.8 0.0 10.6 1.8 0.0 0.1 0.0 16.2 0.0 0.0 0.3 1.0 116.6 5.6 0.8 3.6 1.9 0.6 2.4 1.0 15.6 4.0 0.9 0.1 3.4 1.1 5.0 0.1 1.0 0.3 9.5 6.6 2.9 3.7 77.6 6.7 0.6 0.9 1.1 3.2 2.5 0.1 1.9 USP45 MGC14793 ENSG00000123552 "Ubiquitin specific peptidase 45" Q70EL2 6 99432325-99521728 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease variant, Leber congenital amaurosis" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 7 "brain: 53.5" "Cell type enhanced" "Detected in many" "Excitatory neurons: 47.1;Inhibitory neurons: 44.4;Oligodendrocytes: 39.4" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in all" 6 "cerebellum: 53.5" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029602, HPA029604" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 1: K-562 - Erythropoiesis" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoplasm, Cytosol" "HPA029602: AB_10600418, HPA029604: AB_10602283" "unprognostic (7.81e-3)" "unprognostic (3.10e-3)" "unprognostic (1.63e-2)" "unprognostic (6.62e-2)" "unprognostic (1.02e-2)" "unprognostic (1.92e-1)" "unprognostic (2.15e-2)" "unprognostic (1.01e-1)" "unprognostic (2.77e-2)" "unprognostic (8.65e-2)" "unprognostic (2.95e-3)" "unprognostic (1.10e-1)" "unprognostic (3.43e-3)" "unprognostic (1.13e-1)" "unprognostic (3.53e-1)" "unprognostic (1.43e-1)" "unprognostic (6.91e-2)" 6.1 4.4 5.2 4.9 5.8 4.4 4.6 53.5 9.4 4.3 3.8 5.3 7.3 5.1 4.8 5.3 4.0 6.2 6.2 5.8 6.3 6.3 4.2 3.7 7.4 6.0 7.7 4.5 4.0 4.5 3.6 5.2 8.2 5.1 6.7 6.7 4.0 4.2 6.0 6.3 5.8 4.5 5.3 4.6 4.4 3.3 6.2 3.1 5.3 5.5 5.2 4.3 3.8 9.0 5.9 4.0 8.1 11.2 14.3 13.5 8.7 10.3 11.1 10.1 14.7 8.2 6.4 15.2 7.3 10.3 11.9 7.7 12.1 9.8 13.9 12.2 12.0 15.2 8.4 6.7 11.4 14.2 8.3 15.3 7.6 9.2 15.5 10.7 15.4 13.8 37.2 14.8 9.6 5.5 4.5 13.3 12.8 9.1 8.9 6.8 5.9 8.9 13.8 6.8 11.3 9.2 7.0 9.1 7.8 10.0 4.9 6.8 15.5 5.5 7.1 8.1 15.5 6.3 6.2 29.1 9.8 13.1 10.1 2.9 1.4 0.4 3.2 0.8 4.2 5.3 2.7 4.0 2.4 6.7 1.9 1.9 0.3 1.9 2.0 3.6 2.6 1.0 5.2 5.8 53.5 9.4 5.8 6.3 6.0 7.7 8.2 5.3 6.2 9.0 13.3 3.2 5.8 22.5 13.3 2.3 9.6 6.8 4.6 10.3 4.4 4.6 9.4 4.3 4.7 3.7 18.8 6.4 7.3 5.9 5.9 4.3 15.7 10.1 10.3 7.6 2.4 4.2 47.1 2.5 6.6 7.1 9.7 4.3 2.5 5.8 6.8 4.5 4.0 10.1 44.4 2.9 10.2 4.8 2.6 10.2 13.1 4.6 3.6 22.5 10.0 5.4 2.1 32.6 39.4 5.0 3.1 8.6 6.5 8.6 8.3 15.8 10.4 7.4 0.0 6.3 6.7 1.9 7.5 5.2 2.8 7.4 7.1 5.8 7.3 6.9 USP46 FLJ12552 ENSG00000109189 "Ubiquitin specific peptidase 46" P62068 4 52590960-52659301 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Behavior, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 4 "Bipolar cells: 150.8;Early spermatids: 229.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007288, CAB076369, CAB076370" Uncertain Approved "Nucleoli,Nucleoli rim" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 39: Non-specific - Mitochondria" "Cluster 12: NES - Nervous system development" "Cluster 29: Early spermatids - Spermatogenesis" "Nucleoli, Nucleoli rim" "CAB076369: AB_2665642, CAB076370: AB_2665643, HPA007288: AB_1080531" "unprognostic (1.15e-2)" "unprognostic (1.64e-1)" "unprognostic (1.19e-1)" "unprognostic (1.61e-2)" "unprognostic (1.31e-1)" "unprognostic (1.41e-1)" "unprognostic (1.53e-3)" "unprognostic (1.59e-1)" "unprognostic (2.45e-2)" "unprognostic (1.80e-2)" "unprognostic (2.89e-1)" "unprognostic (1.95e-1)" "unprognostic (1.05e-1)" "unprognostic (1.45e-1)" "unprognostic (3.95e-2)" "unprognostic (2.02e-2)" "unprognostic (1.28e-1)" 4.4 8.6 30.4 3.3 31.2 2.9 6.4 27.4 31.5 7.6 22.4 3.9 4.4 6.5 5.4 11.5 7.0 5.3 28.6 30.8 33.3 9.9 2.9 3.9 3.7 27.9 33.9 11.0 5.2 10.4 4.6 5.3 26.7 6.9 4.0 11.5 8.3 6.7 14.5 7.5 4.2 5.0 30.4 3.3 6.0 12.3 32.5 3.4 9.3 12.5 5.5 6.0 7.4 26.8 8.1 5.7 18.0 13.3 19.1 23.8 19.8 13.0 10.5 9.5 7.9 11.5 6.2 5.4 14.9 13.0 13.4 4.7 31.6 15.1 17.2 4.7 11.1 8.4 5.3 12.8 19.1 11.2 9.4 20.4 13.9 9.7 9.1 18.4 14.2 7.4 8.3 7.4 20.3 7.4 4.8 5.9 13.3 9.0 6.8 12.0 13.1 1.1 20.3 14.8 10.8 12.9 6.4 21.5 12.9 17.1 7.9 8.2 13.3 9.2 20.1 10.9 19.9 7.5 3.7 4.2 14.2 6.7 11.6 0.7 0.4 0.1 0.7 0.4 0.5 0.4 1.2 0.6 0.9 0.4 0.2 0.2 0.1 0.4 0.3 1.4 0.4 0.3 30.4 31.2 27.4 31.5 30.8 33.3 27.9 33.9 26.7 30.4 32.5 26.8 10.0 6.4 7.2 24.2 6.4 5.4 11.2 15.2 26.2 150.8 13.7 11.7 44.9 14.3 16.4 14.7 4.2 12.1 10.7 5.2 21.5 10.8 229.8 18.4 34.9 12.5 4.2 6.7 32.6 12.0 12.5 17.8 17.3 15.6 0.0 22.9 13.6 6.8 5.8 35.3 24.3 5.9 10.2 8.4 4.6 34.1 28.9 7.9 8.8 21.5 12.9 30.0 5.2 30.2 12.6 12.5 9.9 36.1 9.5 21.1 3.9 17.1 23.8 8.7 6.6 16.2 15.9 3.2 14.4 25.9 8.2 7.7 8.0 18.3 7.1 17.7 USP47 ENSG00000170242 "Ubiquitin specific peptidase 47" Q96K76 11 11841423-11961887 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 315.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029286, HPA029289" Supported Approved "Vesicles,Intermediate filaments" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 54: Cardiomyocytes - Muscle contraction" "Intermediate filaments" Vesicles "HPA029286: AB_10599852, HPA029289: AB_10601675" "unprognostic (2.02e-1)" "unprognostic (2.72e-1)" "unprognostic (3.05e-1)" "unprognostic (1.84e-1)" "unprognostic (2.99e-2)" "unprognostic (2.65e-2)" "unprognostic (2.27e-2)" "unprognostic (7.39e-2)" "unprognostic (1.54e-2)" "unprognostic (7.05e-2)" "unprognostic (2.83e-2)" "unprognostic (2.35e-1)" "unprognostic (1.51e-1)" "unprognostic (9.96e-3)" "unprognostic (1.90e-1)" "unprognostic (1.49e-1)" "unprognostic (2.85e-1)" 15.7 14.3 11.9 11.4 15.8 19.0 15.1 17.3 12.8 14.3 10.2 19.8 10.3 17.2 15.6 16.1 13.5 12.3 23.5 12.5 14.1 13.2 23.3 16.2 13.3 14.1 12.8 15.9 16.9 22.2 13.8 16.7 15.0 16.6 12.3 25.7 14.1 15.4 59.8 18.0 14.1 17.8 14.1 11.8 16.6 15.0 12.7 19.1 14.9 33.6 13.8 16.7 14.2 20.6 26.8 15.7 30.3 13.1 21.8 23.2 12.6 31.6 22.3 20.1 22.1 16.5 22.2 29.6 13.3 28.0 23.7 17.8 23.7 15.3 30.3 27.5 20.4 18.6 30.3 12.6 21.5 25.0 23.9 22.3 22.5 12.3 29.0 26.1 21.8 21.7 35.8 23.7 25.4 10.6 21.7 14.3 7.9 28.1 12.7 21.4 30.3 9.4 24.6 29.1 9.8 21.0 25.8 19.6 19.3 18.4 14.4 20.6 24.9 27.8 16.2 22.3 19.6 7.9 18.1 25.9 19.9 15.2 20.3 14.7 5.9 11.9 11.0 7.4 14.5 7.4 10.3 11.4 7.9 6.7 13.1 11.4 2.8 18.5 11.5 4.8 8.3 7.9 11.9 15.8 17.3 12.8 12.5 14.1 14.1 12.8 15.0 14.1 12.7 20.6 41.1 70.5 63.1 116.5 46.9 71.0 68.8 28.8 45.5 67.5 41.1 30.9 222.5 40.0 56.0 23.9 47.9 69.6 57.2 30.4 25.4 39.5 40.1 49.8 63.0 44.8 59.3 34.3 122.7 38.9 33.2 69.7 44.4 134.5 54.3 52.6 32.5 53.9 28.0 63.9 136.5 32.9 24.4 27.7 39.7 30.0 44.1 41.8 24.9 96.5 40.5 79.7 68.0 171.4 315.9 44.8 31.5 50.0 55.2 65.5 29.7 21.9 48.2 52.4 52.6 85.0 68.2 92.8 55.1 46.6 87.9 125.7 65.0 41.8 35.0 58.9 USP48 "FLJ11328, FLJ20103, FLJ23054, FLJ23277, MGC14879, USP31" ENSG00000090686 "Ubiquitin specific peptidase 48" Q86UV5 1 21678298-21783606 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Granulosa cells: 200.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030045, HPA030046" Approved Supported Nucleoplasm,Mitochondria,Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 2: Karpas-707 - Immune response" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "Mitochondria, Cytosol" "HPA030045: AB_10670833, HPA030046: AB_10603325" "unprognostic (1.35e-1)" "unprognostic (3.72e-1)" "unprognostic (5.46e-3)" "unprognostic (2.21e-1)" "unprognostic (1.23e-1)" "unprognostic (7.00e-3)" "prognostic unfavorable (6.09e-8)" "unprognostic (1.04e-2)" "unprognostic (3.01e-3)" "unprognostic (9.30e-2)" "unprognostic (7.54e-2)" "unprognostic (4.45e-2)" "unprognostic (4.16e-3)" "unprognostic (2.03e-1)" "unprognostic (1.06e-1)" "unprognostic (5.70e-2)" "unprognostic (2.80e-2)" 25.8 47.5 18.7 26.6 24.5 43.5 26.4 31.0 26.4 26.9 21.6 24.4 21.7 25.3 20.4 23.0 22.3 18.9 21.6 19.3 20.4 18.2 23.8 23.1 35.1 20.1 20.4 31.1 24.6 25.2 26.9 27.3 21.7 23.5 26.0 57.0 31.2 18.6 23.1 29.5 28.7 22.9 18.5 36.0 32.5 20.6 20.8 26.9 28.6 19.5 34.5 23.1 24.6 36.0 43.9 20.5 47.0 34.0 40.1 49.0 46.4 54.0 36.5 35.3 46.6 19.1 43.2 49.1 35.6 48.8 27.5 39.2 59.0 43.4 53.6 48.3 42.1 104.3 75.7 34.5 35.5 53.0 53.7 39.8 36.6 36.1 39.7 48.1 106.1 36.2 83.8 133.2 44.0 21.9 44.2 68.5 29.7 44.5 36.8 61.3 47.2 57.3 40.7 36.2 57.1 35.6 50.4 45.7 122.7 62.3 23.4 63.0 76.1 37.7 30.9 46.7 31.8 105.6 81.7 48.1 36.3 64.5 56.6 82.1 19.5 35.0 12.2 9.4 13.9 28.6 17.8 17.9 21.1 29.8 20.5 13.1 16.8 12.2 10.9 15.3 21.4 12.6 18.7 24.5 31.0 26.4 19.3 20.4 20.1 20.4 21.7 18.5 20.8 36.0 37.9 54.5 42.1 32.0 55.4 22.2 25.1 30.3 33.0 86.5 22.2 24.5 65.3 21.5 24.4 20.2 62.6 61.4 48.3 17.8 25.4 28.5 71.4 33.3 48.5 32.5 21.7 88.1 66.4 20.0 56.3 42.0 33.1 41.4 49.9 200.4 27.5 22.1 29.2 50.5 74.2 31.3 32.6 22.6 28.1 47.7 34.8 34.4 58.7 52.5 55.9 30.7 36.0 54.3 112.3 23.8 16.4 51.6 150.1 20.7 24.1 20.2 27.3 69.2 32.9 51.7 39.8 52.7 47.4 35.1 25.7 32.6 41.8 54.8 31.6 21.6 USP49 MGC20741 ENSG00000164663 "Ubiquitin specific peptidase 49" Q70CQ1 6 41789896-41895361 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "mRNA processing, mRNA splicing, Ubl conjugation pathway" "Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 43.8;Excitatory neurons: 42.8;Inhibitory neurons: 48.6;Oligodendrocyte precursor cells: 56.3;Oligodendrocytes: 31.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in some" 5 "basophil: 5.1" "Lineage enriched" "Detected in single" 8 "granulocytes: 5.1" "Cell line enhanced" "Detected in all" "REH: 46.7;U-698: 63.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030254, HPA030255" Uncertain NA NA "Cluster 10: Basophils - Unknown function" "Cluster 6: Brain - Smell perception" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 56: Bipolar cells - Visual perception" "HPA030254: AB_10600198, HPA030255: AB_10601218" "unprognostic (1.71e-1)" "unprognostic (4.86e-3)" "unprognostic (1.93e-1)" "unprognostic (2.57e-4)" "unprognostic (4.46e-2)" "unprognostic (2.84e-4)" "unprognostic (7.17e-3)" "unprognostic (5.06e-2)" "unprognostic (1.19e-2)" "unprognostic (3.22e-1)" "unprognostic (5.59e-3)" "unprognostic (8.28e-2)" "unprognostic (1.26e-5)" "unprognostic (5.39e-2)" "unprognostic (4.58e-2)" "unprognostic (4.37e-3)" "unprognostic (3.24e-3)" 2.9 2.8 4.3 2.6 3.2 5.3 2.6 6.0 3.8 3.4 0.4 2.6 1.7 2.9 1.6 1.9 2.6 1.6 2.0 3.3 3.7 2.0 1.6 2.7 2.6 2.7 3.9 3.1 2.0 1.5 2.7 1.4 2.5 2.3 1.5 9.3 2.0 1.6 2.9 3.0 1.7 1.6 0.7 2.5 1.8 4.8 4.1 6.7 7.0 1.0 2.5 2.5 2.6 3.8 6.0 1.8 23.6 11.6 2.8 3.0 9.7 2.3 2.2 3.4 4.3 7.5 1.4 24.5 2.5 2.9 4.9 2.6 14.7 2.2 5.1 6.1 11.0 8.8 10.3 2.7 2.0 6.9 5.2 3.1 1.7 5.0 3.1 3.1 2.2 24.9 18.7 6.4 2.6 3.5 26.7 10.5 6.5 6.4 2.2 46.7 11.3 5.4 1.4 4.1 15.8 6.5 3.1 1.1 1.3 5.5 3.5 6.1 6.1 8.1 8.0 2.6 3.1 12.2 11.4 63.9 1.0 6.9 1.5 5.1 0.4 0.6 0.3 0.4 0.2 0.6 0.2 0.3 0.1 0.4 0.4 0.3 1.0 0.4 0.5 0.3 0.2 0.2 4.3 3.2 6.0 3.8 3.3 3.7 2.7 3.9 2.5 0.7 4.1 3.8 2.4 0.0 9.7 20.2 2.0 5.0 3.0 3.9 1.2 27.5 3.6 3.3 4.6 4.3 6.5 5.5 43.8 2.9 4.5 1.4 1.9 1.9 6.5 4.1 5.0 2.8 0.0 8.2 42.8 2.0 1.6 4.3 3.1 4.6 1.3 4.8 1.4 2.1 2.0 15.2 48.6 1.9 4.1 3.1 4.6 7.2 3.7 3.1 3.6 14.0 5.0 2.8 2.1 56.3 31.8 2.6 1.9 6.0 3.0 4.5 2.1 1.1 7.1 10.9 6.6 6.2 3.4 13.3 14.3 2.7 6.3 5.7 2.4 5.1 2.2 4.6 USP5 IsoT ENSG00000111667 "Ubiquitin specific peptidase 5" P45974 12 6852148-6866632 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006756 Uncertain Approved Nucleoplasm,Cytosol NA NA 1200000 "Cluster 27: Non-specific - Gene expression" "Cluster 59: Non-specific - Translation" "Cluster 5: NTERA-2 - Transcription" "Cluster 66: Spermatocytes - Spermatogenesis" "Nucleoplasm, Cytosol" "HPA006756: AB_1080534" "unprognostic (2.19e-1)" "unprognostic (5.83e-2)" "unprognostic (2.48e-1)" "unprognostic (2.57e-1)" "unprognostic (7.60e-2)" "unprognostic (2.21e-2)" "unprognostic (4.02e-2)" "unprognostic (3.93e-2)" "unprognostic (2.57e-1)" "unprognostic (4.71e-2)" "unprognostic (8.90e-3)" "unprognostic (4.69e-2)" "unprognostic (1.17e-2)" "unprognostic (2.65e-2)" "unprognostic (3.56e-1)" "unprognostic (3.23e-1)" "unprognostic (2.02e-3)" 27.1 37.9 23.7 26.7 26.1 22.8 19.5 15.5 38.0 24.1 2.4 31.3 25.3 31.5 17.4 38.2 25.9 18.5 33.0 25.3 33.6 20.1 23.1 20.5 29.2 31.0 31.3 19.4 17.8 41.4 27.8 25.4 38.8 26.5 22.2 15.7 20.0 29.6 66.7 48.1 26.1 35.5 15.0 21.2 22.9 40.9 28.9 36.5 26.7 42.5 29.4 29.8 24.2 29.0 88.1 135.7 88.4 100.4 59.0 53.9 113.4 93.0 70.9 109.2 78.8 129.4 84.9 105.7 47.6 98.5 86.5 75.2 98.6 92.7 69.5 198.6 84.0 97.1 105.5 71.0 45.8 88.5 97.2 55.6 52.9 94.8 64.9 72.9 94.8 41.7 85.4 40.9 91.1 97.4 132.9 44.4 172.8 89.3 56.5 103.4 115.5 73.5 62.9 84.5 48.5 97.4 63.5 96.3 41.1 110.6 38.3 72.4 92.4 91.5 109.1 70.4 117.6 49.0 124.5 163.8 102.1 55.3 91.3 5.4 19.3 8.3 24.3 25.1 23.1 15.0 21.7 20.8 28.4 13.9 20.1 20.9 1.3 17.6 24.4 20.5 19.9 27.7 23.7 26.1 15.5 38.0 25.3 33.6 31.0 31.3 38.8 15.0 28.9 29.0 11.3 9.6 13.1 7.5 14.0 11.6 11.4 18.0 8.6 18.7 13.1 10.8 9.5 17.2 11.5 22.0 60.5 45.9 14.8 21.5 11.7 28.1 14.7 10.6 14.7 15.3 16.7 19.4 11.5 20.5 30.7 16.6 10.2 13.7 14.7 29.6 11.4 22.2 28.4 40.4 11.9 19.3 14.2 13.0 7.4 19.2 23.0 10.9 16.0 9.4 32.4 16.0 13.4 6.0 11.9 20.2 17.4 33.8 14.1 10.3 22.5 18.5 7.9 16.2 32.9 13.3 17.2 51.7 25.6 17.6 15.5 52.8 15.4 27.6 27.5 7.9 USP50 ENSG00000170236 "Ubiquitin specific peptidase 50" Q70EL3 15 50494018-50546708 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in single" "testis: 1.6" "Group enriched" "Detected in some" 8 "Early spermatids: 107.8;Late spermatids: 58.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA039470 Uncertain NA NA "Cluster 71: Testis - DNA repair" "Cluster 23: Spermatids - Flagellum & Golgi organization" "HPA039470: AB_10672964" "unprognostic (7.05e-3)" "unprognostic (2.38e-1)" "unprognostic (2.01e-2)" "unprognostic (4.04e-3)" "unprognostic (3.37e-1)" "unprognostic (2.53e-2)" "unprognostic (3.95e-2)" "unprognostic (1.73e-2)" "unprognostic (1.51e-1)" "unprognostic (1.42e-1)" "unprognostic (1.85e-1)" "unprognostic (3.81e-2)" "unprognostic (4.65e-2)" "unprognostic (2.47e-1)" "unprognostic (7.49e-4)" "unprognostic (3.03e-1)" 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.3 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.6 0.3 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.3 0.0 1.6 0.1 0.0 0.2 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.3 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 107.8 0.1 0.2 0.1 0.0 0.0 2.6 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.4 0.2 0.1 0.0 3.2 0.0 0.0 0.0 0.0 58.0 0.3 0.2 0.0 2.8 0.0 0.0 0.0 3.0 9.5 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.6 0.1 3.8 0.4 0.0 0.0 0.1 0.1 0.1 0.0 0.1 USP51 ENSG00000247746 "Ubiquitin specific peptidase 51" Q70EK9 X 55484616-55489202 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "epididymis: 51.7" "Cell type enhanced" "Detected in many" "Bipolar cells: 23.7;Muller glia cells: 32.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "SuSa: 7.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA001942 Uncertain Approved "Nucleoli fibrillar center,Cytosol" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 68: Epididymis - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 5: Muller glia cells - Visual perception" Cytosol "Nucleoli fibrillar center" "HPA001942: AB_1080536" "unprognostic (1.19e-2)" "unprognostic (4.65e-2)" "unprognostic (3.67e-2)" "unprognostic (1.02e-3)" "unprognostic (8.08e-2)" "unprognostic (3.26e-1)" "unprognostic (3.17e-3)" "unprognostic (2.07e-3)" "unprognostic (5.69e-2)" "prognostic favorable (5.70e-4)" "unprognostic (1.01e-3)" "unprognostic (1.27e-1)" "prognostic favorable (2.63e-5)" "unprognostic (2.81e-3)" "unprognostic (5.92e-2)" "unprognostic (5.85e-2)" "unprognostic (1.63e-1)" 1.4 3.1 2.5 0.9 2.7 0.5 1.7 2.8 2.8 1.9 4.2 0.8 0.4 3.1 51.7 0.6 5.5 0.8 2.1 2.2 4.2 3.7 1.2 1.5 1.1 2.2 3.1 6.5 1.1 5.6 1.4 2.4 2.4 2.4 0.8 3.1 0.8 2.5 0.4 1.1 0.7 1.9 2.5 1.8 0.8 2.3 3.8 2.4 5.3 1.1 1.2 0.9 0.7 2.5 0.0 0.6 3.9 1.1 1.9 1.0 0.0 0.6 0.3 0.7 0.9 1.2 0.5 0.0 4.6 0.8 0.8 0.2 1.0 0.4 1.2 1.3 0.0 1.0 0.2 0.0 0.8 2.5 0.2 3.9 0.0 0.4 0.0 0.3 0.2 3.0 3.1 3.0 0.6 2.6 2.4 1.3 4.8 0.0 0.2 3.4 0.7 1.5 0.9 0.1 0.0 0.7 1.1 0.1 3.7 7.0 0.9 1.3 0.2 1.5 2.1 0.4 0.1 4.7 2.0 0.9 1.0 1.4 1.0 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.5 2.7 2.8 2.8 2.2 4.2 2.2 3.1 2.4 2.5 3.8 2.5 5.1 3.2 5.5 3.3 2.6 0.9 2.2 0.9 2.2 23.7 3.8 7.4 6.9 1.5 2.0 3.7 6.2 4.3 1.2 0.2 9.8 1.5 0.3 9.0 9.2 6.0 3.6 5.0 2.7 0.0 2.2 8.1 0.0 2.1 1.3 7.9 6.4 0.7 7.6 6.7 5.0 0.5 0.0 5.6 2.5 1.0 4.1 4.7 5.4 1.9 0.3 32.9 3.1 3.5 3.7 0.2 0.3 8.2 1.0 1.0 0.0 13.1 11.2 16.4 0.0 7.1 5.0 11.4 12.5 1.0 0.4 2.7 3.1 13.0 0.4 0.5 USP53 KIAA1350 ENSG00000145390 "Ubiquitin specific peptidase 53" Q70EK8 4 119212587-119295517 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Glandular and luminal cells: 586.8;Microglial cells: 269.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "BJ hTERT+: 327.9;SK-MEL-30: 102.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035844, HPA035845" Uncertain Approved "Plasma membrane,Cytosol" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 44: Endometrium - Transcription" "Plasma membrane, Cytosol" "HPA035844: AB_10669532, HPA035845: AB_2674817" "unprognostic (9.33e-2)" "unprognostic (1.49e-2)" "prognostic favorable (3.15e-6)" "unprognostic (4.37e-3)" "unprognostic (4.82e-2)" "unprognostic (5.03e-2)" "unprognostic (1.55e-1)" "unprognostic (9.54e-2)" "unprognostic (1.77e-1)" "unprognostic (9.81e-3)" "unprognostic (1.28e-1)" "prognostic unfavorable (7.54e-6)" "prognostic favorable (3.58e-8)" "unprognostic (9.02e-2)" "unprognostic (1.72e-1)" "unprognostic (1.58e-1)" "unprognostic (3.70e-2)" 37.8 14.4 5.6 5.7 5.8 0.9 25.3 6.1 6.2 18.5 11.8 16.3 5.7 13.1 13.1 17.0 30.6 10.2 24.0 4.9 7.3 19.9 7.3 29.4 12.4 9.4 8.1 9.4 24.6 8.1 10.3 10.5 7.3 9.2 16.1 3.4 12.7 11.5 33.5 11.7 9.7 10.2 6.5 7.2 15.1 7.8 8.6 5.4 10.5 51.7 8.0 12.7 12.0 5.5 11.4 6.8 2.4 0.0 60.5 60.4 13.6 70.6 327.9 6.2 8.1 7.4 10.4 46.1 2.5 21.1 12.1 5.5 5.5 5.3 16.1 6.1 4.5 3.1 5.2 2.6 47.2 3.9 0.7 20.3 15.0 21.9 31.0 11.7 29.8 3.0 7.3 1.7 8.4 2.5 2.9 5.2 6.7 7.0 3.8 0.9 11.4 9.2 16.4 7.2 3.8 3.0 3.9 27.5 102.4 13.3 7.0 2.7 32.3 2.0 7.0 26.3 6.4 3.3 5.2 7.8 31.4 1.7 7.9 1.3 0.0 0.0 0.4 0.0 0.5 0.7 1.0 0.8 0.1 0.7 1.9 1.0 0.2 0.9 0.0 0.3 0.9 0.3 5.6 5.8 6.1 6.2 4.9 7.3 9.4 8.1 7.3 6.5 8.6 5.5 27.6 35.3 44.5 80.6 18.5 61.8 73.6 21.2 48.3 17.8 74.1 46.6 99.0 32.9 33.9 119.5 29.2 48.4 15.1 207.8 45.0 33.4 5.6 167.2 45.9 35.7 34.6 4.8 32.4 62.7 17.3 86.0 41.8 586.8 70.8 19.8 23.9 30.5 9.3 25.2 32.5 80.4 52.9 21.3 76.4 7.3 19.0 36.5 14.2 269.8 45.6 25.0 12.3 11.6 11.9 110.6 214.5 10.9 18.6 138.6 46.0 20.1 27.3 31.5 6.6 91.8 32.9 18.0 4.0 62.6 42.3 49.8 26.8 14.8 62.6 124.8 USP54 "bA137L10.3, bA137L10.4, C10orf29, FLJ37318" ENSG00000166348 "Ubiquitin specific peptidase 54" Q70EL1 10 73497538-73625994 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 134.8" "Cell type enriched" "Detected in many" 4 "Oligodendrocytes: 476.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "OE19: 33.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA047663, HPA063665" Approved Approved Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 70: Brain - Nervous system development" "Cluster 21: OE19 - Mitochondria" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Mitochondria "HPA047663: AB_2680116, HPA063665: " "unprognostic (2.46e-2)" "unprognostic (1.67e-1)" "unprognostic (3.17e-2)" "unprognostic (1.89e-2)" "unprognostic (2.48e-2)" "unprognostic (4.89e-3)" "unprognostic (6.63e-4)" "prognostic favorable (7.00e-4)" "unprognostic (6.24e-2)" "unprognostic (4.35e-2)" "unprognostic (8.91e-3)" "unprognostic (3.49e-1)" "unprognostic (1.95e-3)" "unprognostic (8.18e-2)" "unprognostic (6.88e-2)" "unprognostic (1.65e-2)" "unprognostic (1.31e-1)" 4.6 3.1 61.5 5.5 103.5 2.1 16.3 85.5 72.4 14.5 32.2 15.0 4.9 9.3 13.2 13.9 12.0 5.6 7.0 60.5 71.9 5.2 1.5 17.9 2.8 99.8 97.5 6.8 10.8 8.9 2.9 2.8 94.0 12.1 19.7 14.8 16.8 7.6 49.7 15.2 6.7 7.1 70.4 2.9 20.7 9.1 85.0 8.4 40.7 17.0 7.1 6.6 4.9 134.8 10.0 8.4 15.9 13.7 4.4 4.8 4.7 4.7 11.2 7.9 8.6 8.1 16.7 6.6 6.5 3.7 6.1 14.2 10.7 4.3 10.2 2.8 8.6 5.0 6.3 8.0 4.1 5.6 2.3 3.9 3.8 9.0 10.9 20.6 3.4 5.7 7.5 3.0 6.3 5.6 4.5 6.8 8.0 33.4 30.2 7.0 11.9 3.0 8.7 7.6 4.8 5.4 10.1 11.7 15.8 10.2 15.8 5.8 4.9 3.5 11.2 6.6 6.8 2.4 4.3 4.1 8.3 5.3 3.1 0.2 0.4 0.5 0.6 0.4 0.7 0.4 0.5 0.4 0.4 0.3 0.7 0.4 0.0 0.3 0.5 0.4 0.6 0.4 61.5 103.5 85.5 72.4 60.5 71.9 99.8 97.5 94.0 70.4 85.0 134.8 5.9 48.1 34.3 33.0 1.7 2.7 8.5 11.0 4.0 7.7 15.3 8.4 7.2 5.7 18.9 12.9 16.7 1.0 1.2 19.6 0.0 4.7 2.4 25.8 12.9 6.3 10.3 2.1 23.1 8.0 1.0 7.6 40.2 44.3 3.8 3.5 2.5 3.0 1.4 5.0 33.4 23.4 2.0 1.3 1.4 2.2 3.4 1.8 8.8 76.8 0.8 12.5 0.0 116.1 476.0 12.2 9.7 10.9 2.3 52.6 10.5 1.9 21.7 12.2 6.6 19.6 3.8 9.2 6.0 7.7 4.0 1.4 3.0 2.9 11.2 15.2 USP6 "HRP1, Tre-2, TRE17, Tre2, TRESMCR" ENSG00000129204 "Ubiquitin specific peptidase 6" P35125 17 5116032-5175034 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Calmodulin-binding, Hydrolase, Protease, Thiol protease" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "skeletal muscle: 19.6;testis: 13.4" "Cell type enhanced" "Detected in many" "Early spermatids: 24.4;Spermatocytes: 26.9" "Cancer enriched" "Detected in single" 14 "testis cancer: 2.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA046969 Uncertain Vesicles NA NA "Cluster 23: Testis - Cell cycle regulation" "Cluster 37: Myocytes - Muscle contraction" Vesicles "HPA046969: " "unprognostic (3.89e-2)" "unprognostic (3.79e-3)" "unprognostic (2.50e-1)" "unprognostic (1.85e-1)" "unprognostic (9.32e-2)" "unprognostic (3.50e-3)" "unprognostic (1.29e-1)" "unprognostic (1.67e-2)" "unprognostic (3.45e-2)" "unprognostic (2.46e-2)" "unprognostic (7.91e-4)" "unprognostic (6.28e-3)" "unprognostic (3.24e-4)" "unprognostic (3.75e-2)" "unprognostic (3.13e-1)" "unprognostic (2.71e-1)" "unprognostic (7.09e-4)" 0.4 0.3 0.2 0.2 0.5 0.1 0.7 0.3 0.6 1.4 1.5 0.8 0.0 0.9 0.7 0.2 0.5 0.5 0.4 0.4 0.3 0.6 0.1 0.4 0.3 0.7 0.2 2.6 0.3 0.0 0.6 0.5 0.6 0.6 0.3 2.5 0.5 0.4 19.6 0.6 0.3 0.9 0.2 0.4 0.2 13.4 0.5 0.0 0.9 0.6 0.2 0.3 0.5 0.9 0.1 0.1 0.3 0.2 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.1 0.2 0.2 0.1 0.1 0.1 0.2 0.0 0.0 0.0 0.3 0.2 0.1 0.3 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.1 0.2 0.1 0.0 0.2 0.4 0.3 0.1 0.1 0.0 0.3 0.2 0.0 0.3 0.2 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.5 0.3 0.6 0.4 0.3 0.7 0.2 0.6 0.2 0.5 0.9 2.0 6.4 10.8 0.0 0.4 10.8 1.0 1.1 0.0 8.5 4.0 3.8 1.6 5.7 3.5 3.7 12.5 0.6 1.0 0.1 3.9 0.0 24.4 1.1 2.1 3.0 0.0 5.3 1.2 0.0 0.8 1.8 0.0 1.4 0.0 1.2 3.6 3.2 2.7 1.7 1.0 0.0 0.0 5.4 6.4 13.5 1.8 3.1 3.6 2.8 3.2 5.1 0.0 0.0 2.9 0.1 0.1 2.6 0.1 2.1 0.0 3.2 4.0 12.3 6.6 5.9 1.7 26.9 11.5 0.0 10.4 0.7 1.1 0.9 0.2 1.1 USP7 HAUSP ENSG00000187555 "Ubiquitin specific peptidase 7" Q93009 16 8892097-8975328 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Biological rhythms, DNA damage, DNA repair, Host-virus interaction, Ubl conjugation pathway" "Developmental protein, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 282.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008108, HPA015641, CAB079904" Approved Supported "Nucleoplasm,Nuclear bodies" NA NA 16000 "Cluster 44: Non-specific - Transcription" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Nucleoplasm "Nuclear bodies" "CAB008108: AB_2233500, CAB079904: AB_2552261, HPA015641: AB_1858700" "unprognostic (6.73e-2)" "unprognostic (1.59e-1)" "unprognostic (3.36e-3)" "unprognostic (1.94e-2)" "unprognostic (9.64e-2)" "unprognostic (8.09e-2)" "unprognostic (4.69e-2)" "unprognostic (4.56e-2)" "unprognostic (4.81e-1)" "unprognostic (2.49e-1)" "unprognostic (2.35e-1)" "unprognostic (9.93e-2)" "prognostic favorable (8.56e-5)" "unprognostic (1.35e-1)" "unprognostic (1.07e-1)" "unprognostic (7.31e-2)" "unprognostic (2.69e-1)" 22.3 16.1 17.6 27.0 19.8 54.6 20.5 20.5 20.7 20.1 15.1 33.1 21.8 21.5 10.1 29.6 19.0 19.9 23.8 21.4 18.1 19.5 25.1 19.3 39.9 16.9 20.1 19.8 26.7 34.8 13.9 23.7 17.5 20.7 32.5 21.7 18.7 18.7 45.2 25.4 25.9 25.7 18.7 24.2 25.5 58.8 18.8 51.1 22.8 41.0 44.9 26.3 17.7 20.8 39.9 73.5 62.2 46.9 34.9 42.9 42.9 53.6 44.7 48.1 40.4 66.6 46.7 94.6 33.8 61.0 27.7 48.8 95.2 61.9 79.6 63.1 38.1 78.4 49.5 132.9 49.0 87.6 48.8 37.3 37.7 52.6 61.0 37.0 69.7 139.8 77.7 101.5 49.6 75.4 130.8 16.9 43.9 49.8 41.4 114.5 69.7 86.2 33.4 77.9 58.8 35.5 59.4 55.3 28.7 62.3 55.0 39.4 60.4 52.1 54.1 80.3 40.4 49.1 134.3 145.1 48.5 49.6 43.5 5.2 2.1 2.8 4.5 2.2 5.7 4.0 4.1 5.3 2.2 4.9 4.9 4.3 3.4 2.8 6.1 6.5 5.1 1.1 17.6 19.8 20.5 20.7 21.4 18.1 16.9 20.1 17.5 18.7 18.8 20.8 40.4 35.3 54.5 22.2 38.0 46.5 23.1 17.9 22.8 51.1 29.7 28.8 74.3 21.5 36.4 29.5 25.0 21.9 51.4 39.8 5.9 22.5 282.4 38.5 50.9 35.8 42.2 46.5 31.4 33.4 14.5 34.4 31.1 57.6 26.6 47.8 25.0 37.5 19.8 43.7 34.9 49.3 10.2 29.2 31.0 112.2 25.4 43.8 19.6 21.5 36.3 29.2 24.7 24.1 30.2 35.6 39.0 34.6 46.8 34.1 31.3 13.7 37.8 44.2 6.6 58.4 39.4 33.8 39.4 41.3 50.0 21.1 40.4 47.6 54.8 35.0 USP8 "HumORF8, KIAA0055, SPG59, UBPY" ENSG00000138592 "Ubiquitin specific peptidase 8" P40818 15 50424380-50514421 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Cancer-related genes, Cushing syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA050215 Approved Supported "Golgi apparatus,Cytosol" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 18: U-2197 - ECM organization" "Cluster 66: Spermatocytes - Spermatogenesis" "Golgi apparatus" Cytosol "HPA050215: AB_2681054" "unprognostic (5.81e-2)" "unprognostic (1.34e-1)" "unprognostic (1.46e-1)" "unprognostic (9.58e-2)" "unprognostic (2.35e-2)" "unprognostic (2.91e-1)" "unprognostic (1.42e-1)" "unprognostic (3.96e-1)" "unprognostic (1.68e-2)" "unprognostic (5.08e-2)" "unprognostic (2.94e-1)" "unprognostic (3.99e-2)" "prognostic favorable (1.29e-5)" "unprognostic (4.89e-2)" "unprognostic (1.13e-1)" "unprognostic (3.79e-1)" "unprognostic (1.58e-1)" 20.3 18.8 11.5 21.1 11.0 27.6 19.6 14.4 13.3 20.5 18.1 21.5 26.7 19.1 10.4 20.7 18.5 16.4 15.1 9.1 14.6 27.0 28.1 19.5 19.0 14.1 13.1 19.9 17.4 45.1 10.6 20.3 12.5 17.0 20.8 22.2 19.8 17.2 17.6 14.2 24.4 18.4 11.5 18.7 22.5 32.0 13.6 20.9 25.4 22.7 24.3 20.0 12.6 13.2 30.6 35.8 23.7 41.1 32.3 44.3 31.0 45.7 43.9 35.7 40.4 19.5 17.7 28.8 35.0 43.5 46.6 57.8 28.8 28.3 39.9 27.2 19.3 52.9 31.9 27.3 35.9 34.3 34.4 32.4 36.2 26.0 55.8 37.0 36.3 23.3 28.4 36.8 32.9 45.9 26.6 12.0 28.5 32.6 17.1 24.1 39.1 45.8 29.5 61.3 29.1 23.8 42.5 55.9 57.4 48.9 35.8 36.9 45.0 41.1 24.1 122.7 52.7 28.5 69.8 32.4 30.6 65.6 40.1 114.6 27.7 50.1 21.4 26.1 22.1 37.3 22.9 23.3 22.7 34.3 24.0 21.2 47.9 22.1 35.0 20.5 20.0 16.0 11.5 11.0 14.4 13.3 9.1 14.6 14.1 13.1 12.5 11.5 13.6 13.2 63.5 96.1 130.8 36.2 101.8 28.9 40.7 47.3 35.9 54.5 41.7 40.0 69.8 51.5 72.7 47.8 68.8 59.0 92.7 79.5 25.4 53.7 153.7 91.5 79.7 53.8 53.3 36.8 41.0 51.3 45.4 55.8 58.1 65.6 86.7 48.5 51.0 56.6 45.4 33.7 44.3 68.7 36.7 73.2 38.2 28.4 53.7 77.6 40.9 46.9 85.3 45.5 72.1 34.7 46.1 57.3 58.2 61.7 87.1 51.0 88.9 49.9 114.9 74.2 46.0 108.2 56.2 140.5 54.8 39.6 41.5 105.2 72.6 77.1 64.8 55.3 USP9X "DFFRX, FAF, MRX99" ENSG00000124486 "Ubiquitin specific peptidase 9 X-linked" Q93008 X 41085445-41236579 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, Cell cycle, Cell division, Chromosome partition, Mitosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011618, HPA047417, CAB070164" Approved Uncertain Vesicles NA NA 24000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Vesicles "CAB011618: AB_470860, CAB070164: AB_10011071, HPA047417: " "unprognostic (5.42e-3)" "unprognostic (6.42e-2)" "unprognostic (3.19e-3)" "unprognostic (2.94e-2)" "unprognostic (5.99e-2)" "unprognostic (4.76e-1)" "unprognostic (1.82e-2)" "unprognostic (4.07e-1)" "unprognostic (1.90e-1)" "unprognostic (1.72e-1)" "unprognostic (7.07e-2)" "unprognostic (1.09e-1)" "unprognostic (5.82e-2)" "unprognostic (1.59e-1)" "unprognostic (4.19e-2)" "unprognostic (2.78e-1)" "unprognostic (1.33e-1)" 16.4 16.8 11.9 14.3 13.9 18.2 14.2 12.7 12.8 15.3 14.3 14.8 13.6 15.4 14.9 14.1 16.0 13.0 15.3 14.3 13.2 17.8 33.9 14.4 15.8 12.2 13.1 13.4 16.0 30.0 10.2 18.4 13.8 12.3 13.7 22.0 11.5 15.3 39.1 13.8 14.3 16.3 12.5 13.3 13.8 17.5 12.8 18.8 19.5 28.4 16.2 15.0 12.6 16.4 38.6 44.2 39.1 40.2 33.0 32.7 8.8 21.5 28.8 23.8 27.5 21.1 16.9 25.7 11.5 48.5 71.3 25.3 67.1 39.7 39.7 32.0 50.5 29.3 41.3 19.9 27.6 26.4 21.0 29.3 17.9 56.4 53.4 35.5 37.2 17.1 36.0 20.3 38.6 29.1 18.8 12.7 42.6 14.1 24.7 20.3 51.8 16.9 24.7 30.7 22.2 20.8 89.0 26.7 26.0 69.8 24.3 16.2 40.2 36.6 27.6 34.6 24.0 19.1 22.3 30.9 26.4 12.1 18.5 1.7 2.3 3.0 2.5 1.9 3.6 2.8 3.0 2.7 2.6 2.1 3.0 2.8 6.4 2.5 2.5 2.1 2.8 1.5 11.9 13.9 12.7 12.8 14.3 13.2 12.2 13.1 13.8 12.5 12.8 16.4 38.1 41.7 35.1 48.0 42.6 48.3 30.8 29.6 55.2 38.1 41.3 29.5 83.5 54.3 37.9 27.6 37.5 39.6 46.3 58.5 7.9 28.4 14.9 85.5 56.9 43.6 26.9 41.0 84.9 26.5 25.4 41.4 41.8 136.9 25.9 58.3 45.7 62.8 32.6 37.0 86.0 39.1 18.3 47.8 42.1 15.4 33.2 55.5 33.8 67.5 44.6 31.3 30.9 74.9 108.0 32.6 40.1 49.2 38.8 35.6 47.7 21.5 35.8 31.2 32.9 70.6 48.3 86.4 82.9 55.2 55.3 46.7 42.4 45.8 38.0 40.2 USP9Y "AZFA, DFFRY" ENSG00000114374 "Ubiquitin specific peptidase 9 Y-linked" O00507 Y 12537650-12860839 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 64.6;Excitatory neurons: 89.5;Inhibitory neurons: 69.5" "Cancer enhanced" "Detected in many" "prostate cancer: 5.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "RPTEC TERT1: 21.5;RT4: 17.4" "Not detected" "Not detected" HPA057687 Uncertain Vesicles NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 54: Non-specific - Microtubule organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Vesicles "HPA057687: " "unprognostic (2.63e-1)" "unprognostic (8.97e-2)" "unprognostic (1.10e-5)" "unprognostic (8.46e-3)" "unprognostic (4.93e-2)" "unprognostic (2.53e-2)" "unprognostic (2.77e-1)" "unprognostic (3.17e-2)" "unprognostic (1.71e-1)" "unprognostic (4.05e-2)" "unprognostic (1.41e-4)" "unprognostic (2.28e-1)" "unprognostic (1.19e-2)" "unprognostic (1.42e-1)" 3.6 5.2 1.3 1.7 1.4 2.6 3.3 2.8 5.2 0.0 2.5 4.5 1.7 0.0 7.2 5.2 0.0 4.6 5.5 1.3 1.4 7.1 3.0 5.2 2.2 1.2 1.1 0.0 6.0 3.5 8.8 2.3 1.3 9.7 4.9 12.9 4.9 7.0 5.2 3.2 4.4 0.0 1.0 5.1 3.9 4.2 1.4 0.0 5.7 9.7 5.6 4.5 0.0 2.4 0.0 4.7 0.0 0.0 0.0 0.0 5.3 14.2 14.6 7.2 8.5 0.0 0.0 7.7 0.0 12.2 0.0 0.0 0.0 0.0 8.6 8.1 0.0 7.3 0.0 9.5 5.8 0.0 0.0 9.7 8.9 0.0 0.0 0.0 0.0 3.0 0.0 0.0 12.2 0.0 9.8 0.0 4.6 0.0 0.0 0.0 3.5 2.1 21.5 17.4 7.2 0.0 0.0 0.0 4.4 12.5 0.0 0.2 10.6 9.5 0.0 0.0 7.0 0.0 9.7 15.1 0.5 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.9 0.4 0.7 0.5 0.1 0.7 0.8 0.5 0.0 0.1 0.0 0.6 0.6 0.0 1.3 1.4 2.8 5.2 1.3 1.4 1.2 1.1 1.3 1.0 1.4 2.4 0.0 25.6 23.5 29.4 11.0 11.7 8.5 9.5 18.2 23.6 0.0 0.0 26.5 7.2 12.6 20.2 64.6 6.3 5.3 0.3 1.9 6.9 0.5 0.0 0.0 5.8 0.0 5.9 89.5 0.0 1.7 8.1 6.6 0.0 2.5 0.0 6.1 2.3 3.1 26.9 69.5 1.1 8.2 5.6 9.3 1.1 12.5 3.6 3.6 31.9 3.6 8.8 14.4 28.6 17.4 2.3 0.0 15.4 4.1 13.2 0.7 6.3 19.9 23.1 0.0 5.2 4.4 2.8 2.6 20.6 11.6 3.4 14.7 0.0 1.5 11.9 USPL1 "bA121O19.1, C13orf22, D13S106E" ENSG00000132952 "Ubiquitin specific peptidase like 1" Q5W0Q7 13 30617693-30660770 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 7 "Early spermatids: 135.8;Late spermatids: 306.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039342, HPA040172" Uncertain NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 2: Immune cells - Immune response" "Cluster 14: REH - Unknown function" "Cluster 25: Spermatids - Spermatogenesis" "HPA039342: AB_10795105, HPA040172: AB_10796447" "unprognostic (5.74e-2)" "unprognostic (6.26e-2)" "unprognostic (8.16e-2)" "unprognostic (4.29e-2)" "unprognostic (4.96e-2)" "unprognostic (3.65e-1)" "unprognostic (1.00e-2)" "unprognostic (1.65e-1)" "unprognostic (1.20e-1)" "unprognostic (6.79e-2)" "unprognostic (2.21e-2)" "unprognostic (1.27e-2)" "unprognostic (3.18e-1)" "unprognostic (2.68e-1)" "unprognostic (1.49e-1)" "unprognostic (3.78e-1)" "unprognostic (5.32e-3)" 11.9 9.9 8.0 8.5 8.5 24.1 11.3 11.0 12.0 10.3 7.9 10.7 6.3 10.9 7.1 7.3 10.0 6.2 8.0 8.5 8.1 12.0 15.6 11.8 12.9 8.0 8.0 13.2 12.1 4.7 8.9 8.2 8.2 10.9 6.5 15.6 9.0 6.6 9.4 9.7 13.7 6.3 8.4 18.6 10.0 19.4 8.4 9.3 10.9 8.3 11.5 10.6 9.6 11.2 4.5 6.5 14.7 9.5 7.5 9.0 6.2 10.1 7.9 9.8 7.9 9.1 11.5 10.1 5.0 8.6 12.8 9.1 16.2 6.1 14.4 8.5 6.6 12.6 10.4 8.0 6.7 12.1 9.6 6.8 10.7 7.2 10.1 14.2 14.2 10.9 12.4 6.6 10.8 3.9 17.3 25.3 12.6 15.0 4.2 15.3 11.3 9.5 7.9 3.0 13.0 11.7 5.5 6.4 9.5 11.3 7.1 15.1 9.0 6.8 6.7 9.2 7.9 6.7 6.3 14.5 3.9 8.7 13.6 3.1 3.8 3.7 3.5 2.8 5.0 5.3 3.4 3.7 3.5 5.7 4.7 4.3 1.8 4.5 2.3 2.6 4.2 3.1 8.0 8.5 11.0 12.0 8.5 8.1 8.0 8.0 8.2 8.4 8.4 11.2 17.6 16.0 9.8 17.3 30.2 4.5 6.6 4.5 17.1 10.1 9.0 8.4 18.2 5.7 7.4 7.3 16.7 4.3 18.6 6.3 3.9 5.1 135.8 9.3 19.6 13.9 14.3 9.5 19.6 4.5 5.9 13.7 13.7 12.1 1.3 9.4 11.0 6.9 7.0 15.2 23.0 11.7 6.1 10.1 15.4 306.1 6.8 18.2 3.6 19.7 6.9 8.9 10.3 21.6 26.8 5.5 5.6 5.3 24.2 8.5 5.7 3.5 6.4 12.0 6.6 13.1 12.6 16.4 8.8 15.5 3.8 3.1 18.2 10.1 8.8 5.0 ZRANB1 TRABID ENSG00000019995 "Zinc finger RANBP2-type containing 1" Q9UGI0 10 124942123-124988189 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029239, HPA029240, HPA029241" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 15: NK-cells - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 44: Endometrium - Transcription" Nucleoplasm Cytosol "HPA029239: AB_10599419, HPA029240: AB_10601450, HPA029241: AB_10602205" "unprognostic (2.06e-1)" "unprognostic (5.16e-2)" "unprognostic (6.96e-2)" "unprognostic (1.67e-1)" "unprognostic (1.40e-1)" "unprognostic (9.53e-3)" "unprognostic (4.16e-2)" "unprognostic (1.89e-1)" "unprognostic (1.71e-1)" "unprognostic (1.46e-1)" "unprognostic (4.20e-1)" "unprognostic (1.46e-1)" "unprognostic (1.22e-2)" "unprognostic (1.60e-1)" "unprognostic (2.76e-1)" "unprognostic (1.26e-1)" "unprognostic (1.47e-2)" 13.9 21.1 17.9 6.6 18.7 22.5 13.1 26.7 21.8 14.4 18.8 13.8 5.1 14.4 12.4 10.5 10.8 9.7 18.4 18.1 17.8 10.9 24.8 10.6 8.2 17.7 17.8 19.3 8.8 16.8 8.7 10.6 17.8 11.2 8.8 17.5 9.0 13.6 52.9 15.0 7.7 15.2 18.0 8.7 8.3 19.7 18.3 13.6 10.1 46.4 10.7 10.3 11.7 19.4 15.1 8.6 17.8 13.1 27.1 22.7 7.5 14.5 39.6 27.1 31.3 12.8 11.7 15.7 10.6 18.4 8.8 10.7 22.8 10.7 36.2 16.8 11.3 9.0 9.7 13.8 57.6 13.6 6.6 25.2 30.8 19.9 42.2 37.7 17.3 14.2 1.3 12.7 14.8 12.1 16.2 11.9 6.5 8.2 9.1 13.7 12.7 7.2 12.0 10.9 9.1 15.2 12.3 9.4 16.4 16.7 10.4 11.5 12.9 11.5 11.8 9.7 18.3 13.4 12.5 18.1 13.1 9.5 5.8 0.9 0.4 1.2 0.8 0.1 0.6 0.9 0.9 0.7 0.3 1.3 1.5 1.2 1.7 1.3 0.2 0.5 0.9 0.3 17.9 18.7 26.7 21.8 18.1 17.8 17.7 17.8 17.8 18.0 18.3 19.4 28.6 19.2 25.3 61.7 17.9 24.6 22.8 10.7 22.2 36.9 29.0 21.2 22.9 15.7 17.3 18.4 50.1 12.3 26.3 16.2 0.0 13.1 80.2 29.4 38.6 21.7 26.8 25.7 58.2 11.6 9.8 21.4 14.3 38.5 26.0 34.3 14.6 43.8 12.5 37.0 58.5 19.0 4.1 16.7 22.4 30.3 23.9 24.3 16.0 52.5 13.2 24.2 19.6 56.3 76.0 19.3 11.5 23.0 21.0 31.4 11.9 10.5 19.2 26.0 13.1 34.6 27.6 28.8 19.1 20.5 27.8 27.5 21.4 23.7 13.1 31.1 ZUP1 "C6orf113, dJ412I7.3, ZUFSP" ENSG00000153975 "Zinc finger containing ubiquitin peptidase 1" Q96AP4 6 116635618-116668794 "Enzymes, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 10.4;dendritic cells: 12.8;monocytes: 12.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044426 Uncertain Supported Nucleoplasm,Cytosol NA NA "Cluster 44: Non-specific - Transcription" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 1: K-562 - Erythropoiesis" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm Cytosol "HPA044426: AB_10960887" "unprognostic (2.28e-3)" "unprognostic (2.45e-3)" "unprognostic (3.91e-2)" "unprognostic (2.17e-1)" "unprognostic (1.33e-2)" "unprognostic (1.63e-1)" "prognostic unfavorable (2.11e-4)" "unprognostic (3.27e-1)" "unprognostic (5.88e-2)" "unprognostic (2.83e-1)" "unprognostic (1.95e-1)" "unprognostic (2.41e-1)" "unprognostic (1.90e-3)" "unprognostic (2.54e-2)" "unprognostic (1.48e-1)" "unprognostic (7.33e-2)" "unprognostic (7.92e-3)" 4.4 4.5 4.2 6.2 4.7 13.5 5.6 7.2 6.3 4.0 3.0 5.1 10.5 3.6 4.1 5.6 3.1 5.5 2.7 4.3 4.6 4.6 4.3 5.0 8.7 4.4 4.4 2.5 5.7 4.2 3.9 5.3 4.6 5.0 5.7 6.0 3.8 4.0 3.1 5.5 7.1 4.1 4.5 6.0 4.7 6.1 4.7 7.5 4.6 3.3 8.7 6.1 4.1 5.9 6.6 6.3 13.9 26.2 7.9 10.3 10.4 14.0 13.3 13.5 16.3 11.5 7.3 23.3 11.6 8.9 15.2 10.3 15.8 10.1 17.9 14.0 18.1 18.0 9.5 20.0 12.3 21.1 21.3 9.2 15.7 11.0 18.7 10.0 12.5 17.4 32.1 11.6 17.9 10.7 10.2 16.0 10.3 9.9 6.8 13.9 12.1 9.6 15.0 6.6 12.1 14.0 10.0 8.3 8.6 11.8 4.9 15.9 10.7 8.6 5.8 5.3 11.9 10.7 14.9 24.0 7.7 12.8 12.8 19.5 7.5 7.6 7.0 8.9 8.2 9.5 7.9 8.1 10.1 10.4 8.6 6.4 2.9 8.3 11.0 6.9 11.7 6.5 4.2 4.7 7.2 6.3 4.3 4.6 4.4 4.4 4.6 4.5 4.7 5.9 6.7 0.0 0.0 0.0 5.5 0.0 0.0 0.0 0.0 0.0 5.3 5.2 0.0 0.0 0.0 1.8 0.0 10.4 12.8 0.0 9.8 9.7 0.0 7.4 8.7 2.2 0.0 0.0 0.0 8.0 8.3 2.2 0.0 8.4 0.0 10.0 0.0 0.0 7.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.4 0.0 0.0 12.4 0.0 0.0 0.0 0.0 10.0 0.0 0.0 3.0 0.0 0.0 9.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 9.3 4.4 6.0 0.0 0.0