Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific nTPM" "RNA single cell type specificity" "RNA single cell type distribution" "RNA single cell type specificity score" "RNA single cell type specific nTPM" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific nTPM" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific nTPM" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific nTPM" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific nTPM" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific nTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific nTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "CCD Protein" "CCD Transcript" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Blood expression cluster" "Tissue expression cluster" "Cell line expression cluster" "Single cell expression cluster" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [nTPM]" "Tissue RNA - adrenal gland [nTPM]" "Tissue RNA - amygdala [nTPM]" "Tissue RNA - appendix [nTPM]" "Tissue RNA - basal ganglia [nTPM]" "Tissue RNA - bone marrow [nTPM]" "Tissue RNA - breast [nTPM]" "Tissue RNA - cerebellum [nTPM]" "Tissue RNA - cerebral cortex [nTPM]" "Tissue RNA - cervix [nTPM]" "Tissue RNA - choroid plexus [nTPM]" "Tissue RNA - colon [nTPM]" "Tissue RNA - duodenum [nTPM]" "Tissue RNA - endometrium 1 [nTPM]" "Tissue RNA - epididymis [nTPM]" "Tissue RNA - esophagus [nTPM]" "Tissue RNA - fallopian tube [nTPM]" "Tissue RNA - gallbladder [nTPM]" "Tissue RNA - heart muscle [nTPM]" "Tissue RNA - hippocampal formation [nTPM]" "Tissue RNA - hypothalamus [nTPM]" "Tissue RNA - kidney [nTPM]" "Tissue RNA - liver [nTPM]" "Tissue RNA - lung [nTPM]" "Tissue RNA - lymph node [nTPM]" "Tissue RNA - medulla oblongata [nTPM]" "Tissue RNA - midbrain [nTPM]" "Tissue RNA - ovary [nTPM]" "Tissue RNA - pancreas [nTPM]" "Tissue RNA - parathyroid gland [nTPM]" "Tissue RNA - pituitary gland [nTPM]" "Tissue RNA - placenta [nTPM]" "Tissue RNA - pons [nTPM]" "Tissue RNA - prostate [nTPM]" "Tissue RNA - rectum [nTPM]" "Tissue RNA - retina [nTPM]" "Tissue RNA - salivary gland [nTPM]" "Tissue RNA - seminal vesicle [nTPM]" "Tissue RNA - skeletal muscle [nTPM]" "Tissue RNA - skin 1 [nTPM]" "Tissue RNA - small intestine [nTPM]" "Tissue RNA - smooth muscle [nTPM]" "Tissue RNA - spinal cord [nTPM]" "Tissue RNA - spleen [nTPM]" "Tissue RNA - stomach 1 [nTPM]" "Tissue RNA - testis [nTPM]" "Tissue RNA - thalamus [nTPM]" "Tissue RNA - thymus [nTPM]" "Tissue RNA - thyroid gland [nTPM]" "Tissue RNA - tongue [nTPM]" "Tissue RNA - tonsil [nTPM]" "Tissue RNA - urinary bladder [nTPM]" "Tissue RNA - vagina [nTPM]" "Tissue RNA - white matter [nTPM]" "Cell RNA - A-431 [nTPM]" "Cell RNA - A549 [nTPM]" "Cell RNA - AF22 [nTPM]" "Cell RNA - AN3-CA [nTPM]" "Cell RNA - ASC diff [nTPM]" "Cell RNA - ASC TERT1 [nTPM]" "Cell RNA - BEWO [nTPM]" "Cell RNA - BJ [nTPM]" "Cell RNA - BJ hTERT+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]" "Cell RNA - CACO-2 [nTPM]" "Cell RNA - CAPAN-2 [nTPM]" "Cell RNA - Daudi [nTPM]" "Cell RNA - EFO-21 [nTPM]" "Cell RNA - fHDF/TERT166 [nTPM]" "Cell RNA - GAMG [nTPM]" "Cell RNA - HaCaT [nTPM]" "Cell RNA - HAP1 [nTPM]" "Cell RNA - HBEC3-KT [nTPM]" "Cell RNA - HBF TERT88 [nTPM]" "Cell RNA - HDLM-2 [nTPM]" "Cell RNA - HEK 293 [nTPM]" "Cell RNA - HEL [nTPM]" "Cell RNA - HeLa [nTPM]" "Cell RNA - Hep G2 [nTPM]" "Cell RNA - HHSteC [nTPM]" "Cell RNA - HL-60 [nTPM]" "Cell RNA - HMC-1 [nTPM]" "Cell RNA - HSkMC [nTPM]" "Cell RNA - hTCEpi [nTPM]" "Cell RNA - hTEC/SVTERT24-B [nTPM]" "Cell RNA - hTERT-HME1 [nTPM]" "Cell RNA - hTERT-RPE1 [nTPM]" "Cell RNA - HUVEC TERT2 [nTPM]" "Cell RNA - JURKAT [nTPM]" "Cell RNA - K-562 [nTPM]" "Cell RNA - Karpas-707 [nTPM]" "Cell RNA - LHCN-M2 [nTPM]" "Cell RNA - MCF7 [nTPM]" "Cell RNA - MOLT-4 [nTPM]" "Cell RNA - NB-4 [nTPM]" "Cell RNA - NTERA-2 [nTPM]" "Cell RNA - OE19 [nTPM]" "Cell RNA - PC-3 [nTPM]" "Cell RNA - REH [nTPM]" "Cell RNA - RH-30 [nTPM]" "Cell RNA - RPMI-8226 [nTPM]" "Cell RNA - RPTEC TERT1 [nTPM]" "Cell RNA - RT4 [nTPM]" "Cell RNA - SCLC-21H [nTPM]" "Cell RNA - SH-SY5Y [nTPM]" "Cell RNA - SiHa [nTPM]" "Cell RNA - SK-BR-3 [nTPM]" "Cell RNA - SK-MEL-30 [nTPM]" "Cell RNA - SuSa [nTPM]" "Cell RNA - T-47d [nTPM]" "Cell RNA - THP-1 [nTPM]" "Cell RNA - TIME [nTPM]" "Cell RNA - U-138 MG [nTPM]" "Cell RNA - U-2 OS [nTPM]" "Cell RNA - U-2197 [nTPM]" "Cell RNA - U-251 MG [nTPM]" "Cell RNA - U-266/70 [nTPM]" "Cell RNA - U-266/84 [nTPM]" "Cell RNA - U-698 [nTPM]" "Cell RNA - U-87 MG [nTPM]" "Cell RNA - U-937 [nTPM]" "Cell RNA - WM-115 [nTPM]" "Blood RNA - basophil [nTPM]" "Blood RNA - classical monocyte [nTPM]" "Blood RNA - eosinophil [nTPM]" "Blood RNA - gdT-cell [nTPM]" "Blood RNA - intermediate monocyte [nTPM]" "Blood RNA - MAIT T-cell [nTPM]" "Blood RNA - memory B-cell [nTPM]" "Blood RNA - memory CD4 T-cell [nTPM]" "Blood RNA - memory CD8 T-cell [nTPM]" "Blood RNA - myeloid DC [nTPM]" "Blood RNA - naive B-cell [nTPM]" "Blood RNA - naive CD4 T-cell [nTPM]" "Blood RNA - naive CD8 T-cell [nTPM]" "Blood RNA - neutrophil [nTPM]" "Blood RNA - NK-cell [nTPM]" "Blood RNA - non-classical monocyte [nTPM]" "Blood RNA - plasmacytoid DC [nTPM]" "Blood RNA - T-reg [nTPM]" "Blood RNA - total PBMC [nTPM]" "Brain RNA - amygdala [nTPM]" "Brain RNA - basal ganglia [nTPM]" "Brain RNA - cerebellum [nTPM]" "Brain RNA - cerebral cortex [nTPM]" "Brain RNA - hippocampal formation [nTPM]" "Brain RNA - hypothalamus [nTPM]" "Brain RNA - medulla oblongata [nTPM]" "Brain RNA - midbrain [nTPM]" "Brain RNA - pons [nTPM]" "Brain RNA - spinal cord [nTPM]" "Brain RNA - thalamus [nTPM]" "Brain RNA - white matter [nTPM]" "Single Cell Type RNA - Adipocytes [nTPM]" "Single Cell Type RNA - Alveolar cells type 1 [nTPM]" "Single Cell Type RNA - Alveolar cells type 2 [nTPM]" "Single Cell Type RNA - Astrocytes [nTPM]" "Single Cell Type RNA - B-cells [nTPM]" "Single Cell Type RNA - Basal keratinocytes [nTPM]" "Single Cell Type RNA - Basal prostatic cells [nTPM]" "Single Cell Type RNA - Basal respiratory cells [nTPM]" "Single Cell Type RNA - Basal squamous epithelial cells [nTPM]" "Single Cell Type RNA - Bipolar cells [nTPM]" "Single Cell Type RNA - Breast glandular cells [nTPM]" "Single Cell Type RNA - Breast myoepithelial cells [nTPM]" "Single Cell Type RNA - Cardiomyocytes [nTPM]" "Single Cell Type RNA - Cholangiocytes [nTPM]" "Single Cell Type RNA - Club cells [nTPM]" "Single Cell Type RNA - Collecting duct cells [nTPM]" "Single Cell Type RNA - Cone photoreceptor cells [nTPM]" "Single Cell Type RNA - Cytotrophoblasts [nTPM]" "Single Cell Type RNA - dendritic cells [nTPM]" "Single Cell Type RNA - Distal enterocytes [nTPM]" "Single Cell Type RNA - Distal tubular cells [nTPM]" "Single Cell Type RNA - Ductal cells [nTPM]" "Single Cell Type RNA - Early spermatids [nTPM]" "Single Cell Type RNA - Endometrial ciliated cells [nTPM]" "Single Cell Type RNA - Endometrial stromal cells [nTPM]" "Single Cell Type RNA - Endothelial cells [nTPM]" "Single Cell Type RNA - Enteroendocrine cells [nTPM]" "Single Cell Type RNA - Erythroid cells [nTPM]" "Single Cell Type RNA - Excitatory neurons [nTPM]" "Single Cell Type RNA - Exocrine glandular cells [nTPM]" "Single Cell Type RNA - Extravillous trophoblasts [nTPM]" "Single Cell Type RNA - Fibroblasts [nTPM]" "Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]" "Single Cell Type RNA - Glandular and luminal cells [nTPM]" "Single Cell Type RNA - granulocytes [nTPM]" "Single Cell Type RNA - Granulosa cells [nTPM]" "Single Cell Type RNA - Hepatic stellate cells [nTPM]" "Single Cell Type RNA - Hepatocytes [nTPM]" "Single Cell Type RNA - Hofbauer cells [nTPM]" "Single Cell Type RNA - Horizontal cells [nTPM]" "Single Cell Type RNA - Inhibitory neurons [nTPM]" "Single Cell Type RNA - Intestinal goblet cells [nTPM]" "Single Cell Type RNA - Ionocytes [nTPM]" "Single Cell Type RNA - Kupffer cells [nTPM]" "Single Cell Type RNA - Langerhans cells [nTPM]" "Single Cell Type RNA - Late spermatids [nTPM]" "Single Cell Type RNA - Leydig cells [nTPM]" "Single Cell Type RNA - Macrophages [nTPM]" "Single Cell Type RNA - Melanocytes [nTPM]" "Single Cell Type RNA - Microglial cells [nTPM]" "Single Cell Type RNA - monocytes [nTPM]" "Single Cell Type RNA - Muller glia cells [nTPM]" "Single Cell Type RNA - NK-cells [nTPM]" "Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]" "Single Cell Type RNA - Oligodendrocytes [nTPM]" "Single Cell Type RNA - Pancreatic endocrine cells [nTPM]" "Single Cell Type RNA - Paneth cells [nTPM]" "Single Cell Type RNA - Peritubular cells [nTPM]" "Single Cell Type RNA - Plasma cells [nTPM]" "Single Cell Type RNA - Prostatic glandular cells [nTPM]" "Single Cell Type RNA - Proximal enterocytes [nTPM]" "Single Cell Type RNA - Proximal tubular cells [nTPM]" "Single Cell Type RNA - Respiratory ciliated cells [nTPM]" "Single Cell Type RNA - Rod photoreceptor cells [nTPM]" "Single Cell Type RNA - Sertoli cells [nTPM]" "Single Cell Type RNA - Skeletal myocytes [nTPM]" "Single Cell Type RNA - Smooth muscle cells [nTPM]" "Single Cell Type RNA - Spermatocytes [nTPM]" "Single Cell Type RNA - Spermatogonia [nTPM]" "Single Cell Type RNA - Squamous epithelial cells [nTPM]" "Single Cell Type RNA - Suprabasal keratinocytes [nTPM]" "Single Cell Type RNA - Syncytiotrophoblasts [nTPM]" "Single Cell Type RNA - T-cells [nTPM]" "Single Cell Type RNA - Theca cells [nTPM]" "Single Cell Type RNA - Undifferentiated cells [nTPM]" "Single Cell Type RNA - Urothelial cells [nTPM]" ACMSD ENSG00000153086 "Aminocarboxymuconate semialdehyde decarboxylase" Q8TDX5 2 134838616-134902034 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Decarboxylase, Lyase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 21 "kidney: 141.1;liver: 162.5" "Group enriched" "Detected in some" 4 "Hepatocytes: 120.2;Proximal tubular cells: 408.1" "Group enriched" "Detected in some" 23 "liver cancer: 21.2;renal cancer: 19.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 21 "RPTEC TERT1: 26.7" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA010533, HPA011179" Enhanced Approved Cytosol NA NA 12000 "Cluster 37: B-cells - Transcription" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Cytosol "HPA010533: AB_1844517, HPA011179: AB_1844516" "unprognostic (1.06e-2)" "unprognostic (5.30e-2)" "unprognostic (1.40e-1)" "unprognostic (7.50e-2)" "unprognostic (3.79e-2)" "unprognostic (1.36e-2)" "unprognostic (4.40e-3)" "unprognostic (1.15e-1)" "unprognostic (5.35e-4)" "unprognostic (7.60e-2)" "unprognostic (5.17e-2)" "unprognostic (2.44e-3)" "prognostic favorable (2.39e-4)" "unprognostic (1.26e-1)" "unprognostic (1.70e-1)" "unprognostic (2.93e-2)" "unprognostic (2.65e-5)" 0.0 0.2 0.1 0.1 0.0 0.2 0.1 0.9 0.3 0.0 0.0 0.1 0.9 0.1 0.0 0.0 0.0 7.1 0.2 0.0 0.3 141.1 162.5 0.1 0.3 0.8 0.2 0.7 0.2 0.0 0.0 0.1 0.1 0.0 0.0 0.4 0.8 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.1 0.4 0.2 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.4 0.2 0.6 0.4 0.0 0.0 0.2 0.6 0.0 0.0 0.0 0.4 0.1 1.1 0.1 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.7 0.4 0.1 0.8 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.8 0.0 0.4 0.6 0.0 0.0 0.3 0.8 0.3 1.2 0.2 0.5 0.1 0.6 0.3 26.7 0.4 1.0 0.3 0.1 0.3 0.4 0.8 0.2 0.7 1.0 0.0 0.4 0.2 0.8 0.2 0.1 0.5 0.2 0.3 0.8 0.0 0.0 0.1 0.1 0.0 0.0 0.2 0.1 0.2 0.1 0.1 0.2 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.9 0.3 0.0 0.3 0.8 0.2 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.3 1.5 0.0 0.0 0.0 0.0 0.0 0.3 0.9 0.2 50.1 0.0 9.2 0.0 0.0 0.0 0.0 54.8 0.2 0.0 0.0 0.1 0.0 0.0 2.7 8.9 0.0 0.0 0.0 0.0 0.4 0.0 0.0 2.9 120.2 0.0 0.0 7.3 0.0 0.0 1.9 0.0 0.0 0.0 2.8 0.0 1.0 0.0 0.0 0.0 2.5 1.9 0.1 0.0 0.0 0.0 0.0 0.0 408.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.1 0.0 0.0 ACO1 "IREB1, IREBP, IRP1" ENSG00000122729 "Aconitase 1" P21399 9 32384603-32454769 "Cancer-related genes, Citric acid cycle related proteins, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Tricarboxylic acid cycle" "Lyase, RNA-binding" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 134.5" "Cell type enhanced" "Detected in all" "Hepatocytes: 194.4;Proximal tubular cells: 183.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "ASC diff: 194.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019371, HPA024157" Enhanced Supported Mitochondria,Cytosol NA NA 10000000 "Cluster 38: Basophils - Unknown function" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Mitochondria, Cytosol" "HPA019371: AB_1844519, HPA024157: AB_1844520" "unprognostic (2.11e-1)" "unprognostic (5.61e-2)" "unprognostic (8.38e-2)" "unprognostic (9.12e-2)" "unprognostic (2.63e-1)" "unprognostic (3.12e-2)" "unprognostic (4.25e-3)" "unprognostic (2.61e-2)" "unprognostic (1.37e-1)" "unprognostic (1.19e-1)" "unprognostic (2.55e-1)" "unprognostic (3.08e-1)" "prognostic favorable (5.73e-5)" "unprognostic (2.54e-1)" "unprognostic (6.58e-2)" "unprognostic (1.65e-1)" "unprognostic (3.23e-2)" 96.6 50.5 15.2 16.1 15.4 3.5 50.1 14.6 15.3 19.8 19.1 23.7 48.6 19.2 30.2 15.4 14.6 15.6 36.3 14.0 16.2 89.2 134.5 20.3 8.8 15.8 15.8 17.4 37.6 22.8 13.1 16.1 14.9 21.9 20.6 12.9 16.6 19.1 25.1 12.0 35.8 22.9 15.3 9.3 28.7 17.6 16.9 13.6 34.5 37.8 7.1 24.4 13.7 14.1 37.5 33.7 25.7 40.7 194.5 104.8 11.6 69.3 169.1 31.2 24.5 36.0 11.4 7.4 21.6 73.1 84.9 5.1 51.3 66.3 62.3 23.8 13.8 54.7 33.4 39.3 97.4 5.1 21.2 91.7 20.1 80.4 56.1 95.6 81.7 28.4 20.0 15.7 89.9 9.9 29.5 26.4 26.9 23.3 35.5 22.8 38.0 7.8 118.9 34.1 3.3 10.5 71.9 2.8 7.6 27.1 16.7 13.5 89.2 112.5 38.2 38.2 18.2 7.8 15.5 14.7 78.7 18.2 10.2 33.2 11.3 3.3 9.2 11.3 8.0 5.6 6.2 6.9 9.3 5.0 8.1 8.2 1.2 6.7 10.0 4.3 3.9 8.4 15.2 15.4 14.6 15.3 14.0 16.2 15.8 15.8 14.9 15.3 16.9 14.1 16.3 3.2 25.7 43.8 6.7 4.5 7.9 11.9 9.1 21.4 17.8 7.4 45.5 38.6 11.7 23.9 22.9 50.8 6.2 26.4 19.6 19.0 8.7 10.0 30.7 18.7 4.9 11.6 24.6 41.0 22.1 29.7 39.3 13.9 2.5 17.1 15.7 194.4 15.1 33.7 46.5 27.7 10.2 14.8 6.7 6.9 23.6 15.6 7.2 20.6 8.6 25.7 8.2 22.1 24.1 19.4 23.7 23.3 7.2 10.1 56.1 183.4 10.7 14.3 19.7 30.5 22.2 9.8 19.4 10.3 5.4 53.5 7.5 22.2 34.6 8.7 ACO2 ACONM ENSG00000100412 "Aconitase 2" Q99798 22 41447830-41529273 "Citric acid cycle related proteins, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Tricarboxylic acid cycle" Lyase "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 567.7;skeletal muscle: 660.4;tongue: 695.8" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 374.2;Proximal tubular cells: 285.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001097 Enhanced Approved Approved Mitochondria NA NA 2000000 "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "HPA001097: AB_1078092" "unprognostic (1.95e-1)" "unprognostic (2.50e-2)" "unprognostic (2.35e-2)" "unprognostic (3.06e-2)" "unprognostic (6.51e-2)" "unprognostic (1.26e-1)" "unprognostic (3.99e-2)" "unprognostic (6.54e-2)" "unprognostic (1.20e-2)" "unprognostic (7.32e-2)" "unprognostic (1.64e-2)" "unprognostic (6.07e-2)" "prognostic favorable (0.00e+0)" "unprognostic (1.46e-2)" "unprognostic (9.60e-2)" "unprognostic (6.45e-2)" "unprognostic (1.12e-2)" 88.8 81.6 154.2 38.6 152.2 32.0 52.4 153.0 190.0 39.5 160.1 94.4 162.9 42.0 26.1 60.4 53.6 36.5 567.7 155.2 153.1 138.9 73.9 40.7 40.5 146.1 145.3 30.8 53.8 233.8 33.6 30.5 147.8 41.2 69.6 46.9 72.0 49.5 660.4 45.5 158.5 43.7 152.5 44.7 110.2 35.1 186.3 38.0 53.7 695.8 43.3 52.5 42.4 159.6 47.2 55.8 56.5 116.3 101.2 69.8 78.7 43.7 60.9 79.0 71.9 81.2 63.5 115.7 72.2 70.6 60.3 109.8 108.8 88.3 42.8 75.8 80.2 51.0 73.7 95.0 86.7 147.8 77.8 120.8 64.4 78.9 83.2 61.7 81.2 61.5 72.9 118.4 65.4 91.7 73.7 47.9 37.0 282.6 115.1 102.3 37.8 162.1 106.8 97.3 37.8 33.9 112.2 128.7 82.0 44.9 74.9 74.7 55.5 60.0 68.7 50.2 45.0 64.7 92.1 80.6 102.0 64.0 66.5 10.3 52.9 18.1 32.0 76.4 29.3 49.4 25.5 34.9 69.0 46.4 29.2 30.8 9.0 39.4 97.1 24.0 41.2 58.6 154.2 152.2 153.0 190.0 155.2 153.1 146.1 145.3 147.8 152.5 186.3 159.6 26.3 25.6 31.8 45.4 49.4 18.7 54.5 102.7 31.3 60.6 28.0 23.2 9.1 64.3 63.5 60.7 81.3 100.3 33.3 190.8 131.0 58.3 14.5 37.2 17.7 26.1 53.2 30.3 28.8 42.6 60.0 24.0 77.5 37.1 40.6 56.7 20.7 64.6 91.5 53.8 34.0 99.1 89.5 35.5 26.4 8.9 24.2 39.2 35.6 7.5 68.3 73.9 34.0 12.1 20.9 43.9 103.5 27.8 63.2 34.4 374.2 285.7 59.2 73.5 59.2 28.6 38.4 26.4 38.2 35.8 16.1 193.2 30.7 54.4 113.6 64.9 ACOD1 "CAD, IRG1" ENSG00000102794 "Aconitate decarboxylase 1" A6NK06 13 76948511-76958638 "Enzymes, Predicted intracellular proteins" "Immunity, Inflammatory response, Innate immunity" "Antimicrobial, Lyase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in single" "lymphoid tissue: 1.4" "Cell type enhanced" "Detected in single" "Distal tubular cells: 1.9" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in single" HPA040143 Uncertain NA NA "Cluster 16: Immune cells - Immune response" "Cluster 41: Macrophages - Immune response" "HPA040143: AB_10793916" "unprognostic (2.39e-1)" "unprognostic (6.42e-2)" "unprognostic (2.37e-1)" "unprognostic (3.54e-2)" "unprognostic (3.09e-1)" "unprognostic (8.30e-2)" "unprognostic (4.30e-2)" "unprognostic (1.64e-5)" "unprognostic (7.70e-2)" "unprognostic (3.68e-2)" "unprognostic (6.51e-3)" 0.2 0.0 0.0 1.4 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ADCY1 "AC1, DFNB44" ENSG00000164742 "Adenylate cyclase 1" Q08828 7 45574140-45723116 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Biological rhythms, cAMP biosynthesis" "Calmodulin-binding, Lyase" "Cancer-related genes, Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 33.7;liver: 19.2;retina: 53.0" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 521.3;Excitatory neurons: 147.2;Inhibitory neurons: 117.9;Rod photoreceptor cells: 174.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "hTERT-HME1: 22.2;SH-SY5Y: 25.5;SK-MEL-30: 30.1;WM-115: 17.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB018364, HPA068274" Uncertain Approved Mitochondria NA NA "Cluster 58: Brain - Synaptic function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 9: Photoreceptor cells - Phototransduction" Mitochondria "CAB018364: AB_2223098, HPA068274: " "unprognostic (9.41e-3)" "unprognostic (7.30e-4)" "unprognostic (9.31e-2)" "unprognostic (2.98e-1)" "unprognostic (4.18e-2)" "unprognostic (3.07e-3)" "unprognostic (1.32e-1)" "unprognostic (7.31e-2)" "unprognostic (1.64e-3)" "unprognostic (2.89e-1)" "unprognostic (7.73e-3)" "unprognostic (1.54e-1)" "unprognostic (4.74e-6)" "unprognostic (2.49e-1)" "unprognostic (7.65e-3)" "unprognostic (2.87e-1)" "unprognostic (2.23e-1)" 1.9 1.8 13.7 0.3 22.4 0.0 4.7 15.4 33.7 5.3 0.0 0.4 0.2 1.8 0.5 0.6 2.0 0.6 2.9 31.9 0.0 1.9 19.2 0.6 0.4 1.2 0.9 0.9 3.3 1.9 2.6 0.4 1.1 2.8 0.4 53.0 0.3 1.2 7.7 0.4 0.3 0.9 0.0 1.7 1.1 2.8 4.0 0.3 2.4 8.5 0.3 0.8 1.3 24.5 0.8 5.9 2.1 3.2 4.1 0.1 4.0 0.2 0.0 0.8 0.3 0.6 0.0 0.0 0.2 0.2 5.8 1.9 3.8 0.3 0.1 10.7 2.7 0.0 0.0 0.6 0.0 0.2 0.1 4.9 2.8 0.5 22.2 0.0 0.1 8.6 0.3 7.0 0.3 7.1 0.0 0.0 8.3 5.1 0.0 0.0 0.0 11.7 0.0 5.7 13.4 25.5 2.1 0.0 30.1 3.1 2.0 3.5 0.0 0.6 4.2 0.5 3.6 0.0 0.0 0.0 0.0 0.0 17.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.7 22.4 15.4 33.7 31.9 0.0 1.2 0.9 1.1 0.0 4.0 24.5 3.5 0.0 0.0 30.7 0.3 0.3 0.6 0.0 0.0 43.8 10.6 5.7 11.4 2.8 0.0 0.0 521.3 0.1 0.3 0.5 1.9 0.0 2.9 1.0 23.1 10.8 31.2 0.0 147.2 0.9 0.2 4.2 0.0 0.7 0.0 0.2 15.7 52.3 0.3 42.1 117.9 1.0 2.0 3.2 0.4 0.7 1.8 0.2 3.6 17.8 0.0 13.8 0.0 63.3 4.0 0.5 0.1 7.5 0.1 2.6 0.0 0.4 0.0 174.4 0.0 2.3 8.8 0.5 6.8 0.1 0.1 0.0 0.6 0.6 0.6 0.3 ADCY10 "HCA2, RP1-313L4.2, SAC, SACI, Sacy" ENSG00000143199 "Adenylate cyclase 10" Q96PN6 1 167809386-167914215 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "cAMP biosynthesis" Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "liver: 6.1;testis: 17.6" "Group enriched" "Detected in some" 7 "Early spermatids: 87.5;Late spermatids: 85.4" "Cancer enhanced" "Detected in single" "liver cancer: 0.7" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "T-47d: 1.4" "Not detected" "Not detected" "Not detected" "Not detected" "HPA015243, HPA017749" Approved NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 6: T47d - Mammary gland" "Cluster 34: Spermatids - Unknown function" "HPA015243: AB_1856540, HPA017749: AB_1856541" "unprognostic (1.20e-1)" "unprognostic (2.53e-1)" "unprognostic (1.95e-2)" "unprognostic (1.17e-2)" "unprognostic (2.05e-1)" "unprognostic (1.65e-1)" "unprognostic (5.35e-2)" "unprognostic (1.56e-1)" "unprognostic (1.63e-1)" "unprognostic (3.65e-1)" "unprognostic (4.43e-2)" "unprognostic (7.83e-5)" "unprognostic (5.86e-7)" "unprognostic (4.73e-2)" "unprognostic (1.33e-1)" "unprognostic (7.83e-2)" "unprognostic (2.59e-1)" 0.1 0.2 1.3 0.0 1.2 0.0 1.0 2.6 2.4 0.2 0.7 0.3 0.3 0.1 0.1 0.1 0.1 0.1 0.2 1.4 0.7 0.4 6.1 0.2 0.0 0.6 0.8 0.1 0.4 0.0 0.1 0.1 0.7 0.4 0.2 0.2 0.1 0.1 0.1 0.1 0.2 0.1 0.6 0.1 0.3 17.6 1.2 0.1 0.1 0.0 0.0 0.1 0.1 1.7 0.1 0.0 0.0 0.0 0.1 0.1 0.7 0.0 0.2 0.0 0.3 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.4 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.5 0.2 0.1 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.1 0.2 0.2 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.4 1.4 0.2 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.3 1.2 2.6 2.4 1.4 0.7 0.6 0.8 0.7 0.6 1.2 1.7 0.1 0.0 0.0 2.0 0.0 0.5 0.2 0.0 0.0 0.0 0.3 0.3 0.6 0.0 0.0 0.0 0.0 0.9 0.0 0.4 0.0 0.0 87.5 0.3 0.2 0.1 0.0 0.0 9.9 0.0 0.7 0.3 0.0 0.1 0.0 0.9 0.7 7.6 0.1 0.0 7.6 0.0 0.0 0.0 0.4 85.4 0.6 0.1 0.0 1.0 0.0 0.0 0.0 3.5 3.6 0.0 0.0 0.4 0.0 0.2 1.1 0.2 0.0 0.0 0.0 0.2 0.4 11.3 0.6 0.1 0.4 1.8 0.0 0.8 0.2 0.2 ADCY2 "AC2, HBAC2, KIAA1060" ENSG00000078295 "Adenylate cyclase 2" Q08462 5 7396138-7830081 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "cAMP biosynthesis" Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "brain: 50.8;skeletal muscle: 68.3;tongue: 30.8" "Group enriched" "Detected in many" 5 "Astrocytes: 647.1;Excitatory neurons: 406.6;Horizontal cells: 201.9;Inhibitory neurons: 423.9;Oligodendrocyte precursor cells: 181.5" "Cancer enhanced" "Detected in some" "glioma: 4.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "AF22: 5.6;NTERA-2: 4.3;SK-MEL-30: 4.6;SuSa: 3.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB031482, HPA038015, HPA038483" Approved NA NA "Cluster 80: Striated muscle - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "CAB031482: AB_630838, HPA038015: AB_10673653, HPA038483: AB_10675799" "unprognostic (6.48e-2)" "unprognostic (2.60e-2)" "unprognostic (1.49e-1)" "unprognostic (5.65e-2)" "unprognostic (3.77e-1)" "unprognostic (4.03e-4)" "unprognostic (1.94e-2)" "unprognostic (1.60e-2)" "unprognostic (2.20e-1)" "unprognostic (1.48e-1)" "unprognostic (2.67e-2)" "unprognostic (7.68e-2)" "unprognostic (1.09e-5)" "unprognostic (1.05e-1)" "unprognostic (7.33e-3)" "unprognostic (4.90e-2)" "unprognostic (3.92e-3)" 1.4 2.2 32.3 0.3 39.1 0.1 1.8 25.9 39.9 4.5 8.0 3.2 0.9 3.2 0.6 3.0 3.0 1.1 0.4 38.2 37.6 0.2 0.0 0.3 0.0 43.4 44.1 3.9 0.8 0.4 6.3 0.8 34.1 5.2 0.5 7.0 1.8 3.9 68.3 5.4 1.1 3.3 50.8 0.2 1.6 2.7 33.8 0.2 0.4 30.8 0.1 1.9 3.1 37.8 0.0 0.0 5.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 4.6 3.8 0.1 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 32.3 39.1 25.9 39.9 38.2 37.6 43.4 44.1 34.1 50.8 33.8 37.8 0.3 3.2 2.7 647.1 0.1 5.9 0.7 0.1 0.0 26.8 1.5 1.5 2.2 1.5 2.6 0.0 68.8 0.6 0.2 0.2 0.0 0.6 3.2 0.2 1.6 1.3 12.6 0.0 406.6 0.5 0.3 3.5 0.0 0.2 1.3 3.2 0.4 0.2 0.2 201.9 423.9 1.2 0.0 0.0 5.0 4.9 4.4 0.9 40.9 20.6 0.0 2.0 0.0 181.5 10.6 3.6 7.6 1.9 0.0 8.0 0.2 0.2 5.3 4.9 0.0 11.9 0.9 1.2 1.7 0.0 4.7 0.8 0.7 0.3 0.4 1.4 ADCY3 AC3 ENSG00000138031 "Adenylate cyclase 3" O60266 2 24819169-24920237 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "cAMP biosynthesis, Olfaction, Sensory transduction" "Calmodulin-binding, Lyase" Obesity "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Leydig cells: 58.4;Sertoli cells: 111.7;Smooth muscle cells: 62.8;Theca cells: 92.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB010223 Approved NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 48: Smooth muscle cells - ECM organization" "CAB010223: AB_630839" "unprognostic (3.05e-1)" "unprognostic (1.10e-1)" "unprognostic (4.91e-2)" "unprognostic (1.39e-3)" "unprognostic (5.01e-2)" "unprognostic (7.66e-2)" "unprognostic (1.28e-1)" "unprognostic (6.06e-2)" "unprognostic (8.43e-2)" "unprognostic (6.89e-2)" "unprognostic (8.22e-3)" "unprognostic (2.52e-1)" "prognostic unfavorable (1.32e-9)" "unprognostic (3.74e-2)" "unprognostic (5.56e-2)" "unprognostic (1.11e-1)" "unprognostic (8.55e-3)" 94.4 17.3 43.5 17.3 55.1 17.7 74.6 36.7 50.1 66.7 28.4 27.5 10.9 56.4 20.5 30.4 62.1 23.0 36.6 43.3 43.4 25.9 6.6 42.5 18.9 41.6 43.8 71.9 15.7 17.0 41.7 83.6 41.1 40.6 15.8 4.2 21.6 33.0 15.2 38.4 34.4 35.3 36.9 30.4 25.0 9.8 50.6 11.4 36.8 20.4 18.1 36.4 48.9 44.9 76.5 40.4 17.2 28.3 84.5 75.4 29.6 32.3 65.9 37.1 37.8 38.6 25.1 26.0 6.2 53.2 51.0 54.5 43.1 54.5 24.0 58.4 55.8 43.0 40.0 1.7 64.0 24.0 24.6 55.7 47.5 36.6 50.8 23.6 33.8 27.9 15.5 49.2 19.3 43.6 17.9 2.1 14.9 39.9 24.4 38.8 75.3 59.5 15.5 38.7 31.6 19.1 45.8 54.2 30.2 13.0 13.5 22.5 33.5 59.7 34.2 39.1 54.1 42.4 101.6 113.6 18.7 39.2 31.4 2.6 1.5 0.0 0.4 1.6 0.3 5.5 0.9 0.5 9.5 6.0 0.7 0.5 0.0 1.2 0.4 9.0 3.4 1.0 43.5 55.1 36.7 50.1 43.3 43.4 41.6 43.8 41.1 36.9 50.6 44.9 14.6 0.0 1.8 17.0 8.2 11.0 4.2 4.1 5.2 3.0 18.6 8.0 2.8 0.0 1.3 1.8 0.0 1.0 5.2 5.0 0.0 0.9 0.3 1.9 42.2 10.6 1.2 5.2 40.1 0.0 2.1 25.5 2.0 2.2 18.4 3.7 5.0 0.3 12.6 0.0 36.8 6.0 2.0 5.4 6.9 3.9 58.4 10.1 7.2 21.5 4.0 1.6 0.0 15.1 33.2 1.0 5.8 29.3 4.9 11.2 8.3 0.2 1.1 2.2 111.7 6.5 62.8 0.4 2.4 4.4 11.8 1.2 7.2 92.9 12.1 3.9 ADCY4 AC4 ENSG00000129467 "Adenylate cyclase 4" Q8NFM4 14 24318349-24335093 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "cAMP biosynthesis" Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in many" 5 "Adipocytes: 90.9;Endothelial cells: 74.6;Hepatic stellate cells: 50.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 9 "basophil: 2.9" "Lineage enriched" "Detected in single" 9 "granulocytes: 2.9" "Group enriched" "Detected in some" 6 "HUVEC TERT2: 2.9;TIME: 5.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB005070, HPA048344" Approved NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "CAB005070: AB_2273639, HPA048344: AB_2680366" "unprognostic (5.59e-2)" "unprognostic (1.34e-1)" "unprognostic (3.47e-4)" "prognostic favorable (8.20e-4)" "unprognostic (4.06e-1)" "unprognostic (2.82e-3)" "unprognostic (1.75e-4)" "unprognostic (8.58e-2)" "unprognostic (2.51e-2)" "unprognostic (7.88e-2)" "unprognostic (6.77e-2)" "unprognostic (7.87e-2)" "prognostic unfavorable (7.01e-4)" "unprognostic (8.02e-2)" "unprognostic (3.88e-2)" "unprognostic (1.57e-1)" "unprognostic (3.47e-2)" 18.0 2.6 2.8 2.3 2.2 0.0 16.1 2.2 2.8 9.2 2.0 3.9 0.9 8.8 0.5 3.7 8.2 2.9 16.9 2.0 2.1 10.2 1.4 9.9 1.6 2.7 2.5 2.4 2.3 1.0 1.7 9.9 2.6 5.3 0.7 0.0 3.7 1.4 4.3 4.7 4.5 1.9 2.4 9.9 3.7 1.1 3.0 0.4 7.7 2.8 0.8 5.9 6.7 2.3 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.3 0.0 0.3 0.2 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.4 0.0 0.1 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 5.1 0.1 0.0 0.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.9 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 2.8 2.2 2.2 2.8 2.0 2.1 2.7 2.5 2.6 2.4 3.0 2.3 90.9 0.0 1.8 0.3 1.0 3.6 0.4 0.3 3.4 0.0 1.5 1.5 10.6 0.0 0.9 1.8 0.0 0.2 1.6 2.9 0.0 1.2 1.3 0.5 1.1 74.6 1.2 0.4 0.2 3.1 0.1 4.7 7.1 0.6 1.3 0.0 50.3 0.2 1.4 1.7 0.2 7.9 0.0 5.0 3.1 6.9 0.0 1.5 7.2 12.2 2.5 0.9 1.0 0.0 0.0 2.1 3.8 0.0 1.4 0.4 2.4 0.0 1.1 0.2 6.6 1.7 5.7 0.3 0.8 0.6 2.8 0.0 1.6 0.5 2.1 0.2 ADCY5 AC5 ENSG00000173175 "Adenylate cyclase 5" O95622 3 123282296-123449090 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "cAMP biosynthesis" Lyase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 97.7;heart muscle: 105.2" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 75.5;Inhibitory neurons: 44.0;Oligodendrocytes: 89.7;Paneth cells: 59.6;Peritubular cells: 73.7;Sertoli cells: 65.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "MCF7: 15.5;RPMI-8226: 2.7;RPTEC TERT1: 5.2" "Region enriched" "Detected in all" 5 "basal ganglia: 388.0" "Region enriched" "Detected in all" 6 "basal ganglia: 155.9" "HPA017730, HPA077682" Uncertain Enhanced "Intermediate filaments" NA NA "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 54: Cardiomyocytes - Muscle contraction" "Intermediate filaments" "HPA017730: AB_1844595, HPA077682: AB_2686851" "unprognostic (3.55e-2)" "unprognostic (1.01e-3)" "unprognostic (7.61e-3)" "unprognostic (2.05e-2)" "unprognostic (1.25e-1)" "unprognostic (1.26e-2)" "unprognostic (1.48e-1)" "unprognostic (7.61e-2)" "unprognostic (2.49e-2)" "unprognostic (2.34e-1)" "unprognostic (7.27e-3)" "unprognostic (2.64e-2)" "prognostic favorable (7.46e-6)" "unprognostic (1.81e-2)" "unprognostic (5.65e-2)" "unprognostic (3.19e-2)" "unprognostic (5.97e-4)" 18.9 3.3 25.5 4.9 97.7 0.0 10.6 13.9 43.9 9.8 0.0 35.1 5.2 14.7 5.7 18.8 12.7 10.0 105.2 25.8 15.9 12.8 3.3 4.1 2.3 20.5 18.3 13.2 7.5 0.8 14.3 6.1 17.4 19.8 5.6 4.5 4.0 21.5 2.7 2.6 13.0 18.2 10.8 6.5 21.2 8.2 34.4 1.3 1.9 5.8 3.0 23.2 7.8 30.1 0.0 0.6 1.3 0.1 0.1 0.1 0.3 0.0 0.0 0.3 0.0 0.1 0.1 0.0 0.3 0.2 2.3 0.5 0.6 0.0 0.0 0.1 0.8 0.0 0.2 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 15.5 0.0 0.0 0.8 0.0 0.1 0.0 0.3 2.7 5.2 0.5 1.8 1.6 0.0 0.5 0.1 1.7 0.0 0.1 0.0 0.1 1.2 0.1 0.2 0.1 0.6 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 25.5 97.7 13.9 43.9 25.8 15.9 20.5 18.3 17.4 10.8 34.4 30.1 0.3 0.0 0.0 8.1 0.1 0.3 0.1 0.2 0.0 21.8 0.4 5.8 75.5 8.6 0.0 7.3 0.0 1.4 0.0 2.6 0.0 15.9 0.9 1.5 7.1 1.8 0.0 0.0 34.0 6.9 4.0 5.2 0.0 4.0 0.0 4.6 3.9 0.1 0.3 0.0 44.0 0.3 0.0 0.0 0.3 3.0 20.5 0.1 0.0 6.5 1.0 1.0 0.0 19.1 89.7 0.4 59.6 73.7 0.0 0.1 0.3 0.8 0.0 2.2 65.7 0.6 21.4 0.8 6.3 0.2 0.9 12.4 0.2 1.0 2.0 0.1 ADCY6 AC6 ENSG00000174233 "Adenylate cyclase 6" O43306 12 48766194-48789089 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "cAMP biosynthesis" Lyase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 38.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "SK-BR-3: 68.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB018365 Approved Approved "Golgi apparatus" NA NA "Cluster 46: Fibroblasts - ECM organization" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "Golgi apparatus" "CAB018365: AB_2257941" "unprognostic (1.18e-2)" "unprognostic (2.20e-2)" "unprognostic (6.89e-2)" "unprognostic (1.31e-1)" "unprognostic (3.84e-2)" "unprognostic (3.68e-2)" "prognostic unfavorable (8.23e-4)" "unprognostic (1.55e-1)" "unprognostic (1.07e-1)" "unprognostic (1.29e-1)" "unprognostic (2.59e-1)" "unprognostic (1.64e-2)" "unprognostic (5.06e-3)" "unprognostic (5.10e-3)" "unprognostic (1.09e-1)" "unprognostic (3.09e-1)" "unprognostic (2.48e-2)" 43.2 15.0 8.9 6.1 7.9 1.3 23.7 5.0 9.2 19.3 10.3 26.3 18.7 20.7 19.0 10.3 17.1 13.9 57.2 8.0 11.2 21.1 9.6 13.5 3.9 5.5 5.4 22.3 22.3 20.7 14.6 14.5 6.6 16.3 20.3 5.7 33.5 16.5 12.1 15.3 21.4 13.6 1.9 4.8 25.1 4.0 14.4 2.8 17.9 12.7 3.2 12.3 12.8 6.4 14.0 25.9 30.2 18.9 32.0 15.9 32.0 16.7 17.1 19.8 13.8 45.7 45.3 0.0 37.2 15.3 8.2 10.9 9.2 11.6 7.9 0.1 13.4 12.5 37.8 8.4 17.6 0.0 10.1 20.0 13.6 17.1 6.5 37.9 18.7 0.8 1.7 4.5 15.6 23.1 0.0 0.5 10.3 21.6 12.3 4.6 11.4 7.7 23.4 41.5 4.5 18.4 17.2 68.0 15.2 13.3 53.3 3.5 21.1 18.3 13.1 9.7 7.4 7.0 3.7 0.4 16.9 0.0 8.6 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 8.9 7.9 5.0 9.2 8.0 11.2 5.5 5.4 6.6 1.9 14.4 6.4 11.6 0.0 6.4 18.3 0.6 2.7 3.3 7.5 4.0 10.1 22.7 15.0 8.2 7.2 9.8 18.4 20.9 7.4 0.4 38.8 0.0 5.8 0.8 6.8 8.0 8.1 8.4 0.0 17.5 4.0 2.7 7.6 14.3 11.3 1.3 14.6 5.0 7.7 2.5 10.1 18.8 24.9 8.2 0.6 2.8 1.1 11.5 0.7 7.2 7.5 0.6 3.4 0.0 15.1 7.0 9.5 30.3 9.4 0.3 6.3 26.0 2.8 5.8 9.3 19.7 9.5 26.6 1.9 1.7 3.6 2.0 5.1 0.8 13.9 23.7 9.3 ADCY7 "AC7, KIAA0037" ENSG00000121281 "Adenylate cyclase 7" P51828 16 50246137-50318135 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "cAMP biosynthesis" Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "dendritic cells: 42.8;granulocytes: 50.6;Kupffer cells: 65.1;Langerhans cells: 48.0;Macrophages: 45.4;Microglial cells: 52.5;monocytes: 42.4;NK-cells: 76.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HEL: 81.0;HMC-1: 194.6;RPMI-8226: 100.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA041218, HPA048241" Uncertain Approved Cytosol NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 16: Immune cells - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "HPA041218: AB_2677365, HPA048241: AB_2680326" "unprognostic (1.98e-1)" "prognostic unfavorable (5.31e-4)" "unprognostic (1.24e-1)" "unprognostic (1.78e-1)" "unprognostic (3.77e-1)" "unprognostic (2.80e-1)" "unprognostic (3.90e-2)" "unprognostic (7.75e-2)" "unprognostic (1.21e-1)" "unprognostic (2.56e-2)" "unprognostic (1.65e-1)" "unprognostic (1.18e-1)" "unprognostic (5.59e-3)" "unprognostic (7.34e-2)" "unprognostic (2.15e-3)" "unprognostic (2.18e-1)" "unprognostic (9.52e-4)" 8.1 3.9 6.8 23.9 7.3 24.7 5.6 7.8 8.8 3.9 6.9 8.2 4.1 3.7 2.3 14.3 7.6 12.4 5.5 6.2 10.6 1.6 3.8 23.3 27.1 14.4 11.4 19.4 2.0 1.6 2.0 14.5 12.8 2.7 8.8 0.8 4.0 2.1 2.2 13.7 8.6 7.8 10.9 29.7 7.8 1.9 12.9 19.3 2.4 3.5 24.5 7.6 4.7 19.1 16.3 18.5 0.7 2.6 1.9 24.0 1.7 9.7 4.5 8.1 7.0 23.4 28.4 4.2 25.4 41.0 0.5 50.5 22.3 10.0 8.9 50.7 6.9 81.0 18.4 5.8 20.6 10.6 194.6 12.0 8.5 5.7 8.3 4.4 2.3 17.7 30.4 7.9 10.5 9.2 5.8 34.9 3.5 8.4 31.1 5.7 7.1 100.6 5.0 1.1 4.0 9.8 5.4 2.0 4.8 4.4 0.1 38.7 17.6 0.9 25.5 2.9 3.6 0.3 0.6 8.5 9.3 32.6 3.4 9.2 7.6 2.8 6.9 10.7 5.1 2.8 2.9 5.2 12.2 3.3 2.5 3.6 4.1 9.5 18.1 6.8 4.4 5.6 6.8 7.3 7.8 8.8 6.2 10.6 14.4 11.4 12.8 10.9 12.9 19.1 1.4 19.2 35.9 2.0 15.4 3.7 0.4 0.6 1.2 1.2 1.3 2.8 1.0 0.0 7.9 0.0 6.2 11.6 42.8 3.3 0.0 1.9 1.5 6.7 6.5 1.9 0.0 12.4 6.4 0.2 1.8 9.2 3.6 13.6 50.6 4.7 1.4 0.5 35.2 0.0 3.8 0.7 0.0 65.1 48.0 1.3 0.6 45.4 5.4 52.5 42.4 0.5 76.2 3.5 0.7 4.2 10.4 1.2 15.6 0.5 0.1 0.2 1.0 0.8 6.6 28.3 2.2 0.0 1.5 7.2 4.0 4.0 26.6 16.0 2.3 1.3 ADCY8 "AC8, ADCY3, HBAC1" ENSG00000155897 "Adenylate cyclase 8" P40145 8 130780301-131040909 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "cAMP biosynthesis" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 7 "brain: 29.4;epididymis: 22.8" "Group enriched" "Detected in some" 5 "Astrocytes: 151.8;Inhibitory neurons: 250.9;Oligodendrocyte precursor cells: 138.7" "Group enriched" "Detected in some" 5 "glioma: 6.0;ovarian cancer: 1.8;thyroid cancer: 1.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC TERT1: 5.0;GAMG: 8.2;U-138 MG: 17.6;U-87 MG: 34.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB018652, HPA024291" Supported NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB018652: AB_633654, HPA024291: AB_1844597" "unprognostic (5.59e-3)" "unprognostic (3.10e-1)" "unprognostic (1.82e-1)" "unprognostic (1.09e-1)" "unprognostic (2.78e-2)" "unprognostic (1.74e-1)" "unprognostic (1.05e-1)" "unprognostic (8.22e-3)" "unprognostic (4.91e-2)" "unprognostic (7.39e-3)" "unprognostic (1.92e-1)" "unprognostic (2.44e-2)" "unprognostic (6.67e-2)" 0.0 0.0 17.0 0.0 13.4 0.0 0.5 19.7 9.6 0.4 1.7 0.0 0.0 0.0 22.8 0.0 3.9 0.0 0.0 11.9 14.0 0.2 0.0 1.2 0.0 17.2 22.6 0.0 0.0 0.0 0.0 0.0 15.2 0.0 0.0 3.1 1.1 1.4 0.1 2.1 0.0 0.5 25.9 0.0 0.1 0.5 29.4 0.0 0.0 0.0 0.0 0.0 0.0 23.3 0.0 0.0 0.0 0.1 1.3 5.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 17.6 0.4 0.0 0.0 0.0 0.0 0.0 34.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.0 13.4 19.7 9.6 11.9 14.0 17.2 22.6 15.2 25.9 29.4 23.3 0.0 0.0 1.5 151.8 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.7 0.0 0.0 0.0 0.0 0.0 32.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 250.9 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 8.4 0.0 0.1 0.0 138.7 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ADCY9 AC9 ENSG00000162104 "Adenylate cyclase 9" O60503 16 3953387-4116442 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "cAMP biosynthesis" Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "choroid plexus: 45.4;skeletal muscle: 52.9" "Cell type enhanced" "Detected in many" "Excitatory neurons: 95.3;Inhibitory neurons: 72.7;Oligodendrocyte precursor cells: 42.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 40.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041328, HPA044225" Approved Approved Cytosol NA NA "Cluster 10: Basophils - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 20: HeLa - Mitochondria" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "HPA041328: AB_2677414, HPA044225: AB_2678863" "unprognostic (1.78e-1)" "unprognostic (5.54e-2)" "unprognostic (2.57e-1)" "prognostic unfavorable (2.55e-5)" "unprognostic (6.62e-2)" "unprognostic (1.30e-2)" "unprognostic (2.52e-1)" "unprognostic (3.61e-2)" "unprognostic (6.93e-2)" "unprognostic (4.76e-3)" "unprognostic (5.40e-2)" "unprognostic (1.37e-1)" "prognostic favorable (5.24e-8)" "unprognostic (1.19e-1)" "unprognostic (1.66e-1)" "unprognostic (1.44e-1)" "unprognostic (1.55e-2)" 6.9 5.6 5.1 4.4 7.6 1.5 6.1 3.2 7.5 8.2 45.4 8.2 8.2 8.0 2.4 8.4 9.2 6.9 14.9 10.7 0.0 9.4 11.9 14.0 1.9 3.0 0.6 11.2 15.8 9.1 5.1 9.9 0.9 4.4 6.8 2.9 11.9 5.8 52.9 5.9 9.6 7.9 0.1 4.4 6.4 4.0 1.3 2.1 18.8 28.6 2.6 9.7 6.1 5.2 8.5 12.9 3.8 7.0 13.3 16.0 5.6 14.5 15.1 8.0 6.3 10.6 7.2 0.0 21.8 40.1 4.8 8.0 14.9 9.1 5.4 10.4 14.3 0.3 29.4 20.3 14.2 1.1 6.4 17.1 13.6 9.3 4.9 6.6 5.4 2.7 4.7 0.0 8.3 15.3 0.1 4.4 6.9 3.6 6.9 13.3 18.0 0.4 2.9 2.3 8.7 3.8 11.3 13.2 9.6 4.2 33.5 15.0 4.9 15.8 4.3 15.6 6.4 3.2 2.1 1.7 3.4 4.4 6.3 0.8 0.3 0.2 0.4 0.3 0.4 0.0 0.1 0.1 0.0 0.0 0.0 0.2 0.1 0.3 0.0 0.2 0.0 0.3 5.1 7.6 3.2 7.5 10.7 0.0 3.0 0.6 0.9 0.1 1.3 5.2 7.0 12.8 12.8 33.3 1.0 6.4 1.1 3.9 5.2 10.6 4.2 3.7 17.3 22.8 7.1 12.9 12.5 1.8 5.8 19.5 0.0 4.5 0.8 6.1 10.5 6.3 1.2 0.4 95.3 5.3 1.8 8.1 1.5 5.7 0.0 15.3 8.2 19.9 1.5 1.7 72.7 7.6 2.0 4.7 2.0 2.2 8.4 3.3 7.2 31.9 2.6 5.5 4.1 42.3 12.5 3.5 4.3 7.5 2.5 1.1 15.0 5.6 9.5 14.9 0.0 9.4 12.5 1.1 5.0 0.9 3.8 1.0 3.4 4.8 7.2 1.3 ADSL ENSG00000239900 "Adenylosuccinate lyase" P30566 22 40346461-40390463 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Purine biosynthesis" Lyase "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 6 "skeletal muscle: 345.1;tongue: 242.3" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000525, CAB019285" Enhanced Enhanced Cytosol NA NA 440000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Cytosol "CAB019285: , HPA000525: AB_1078106" "unprognostic (2.80e-1)" "unprognostic (2.12e-1)" "prognostic favorable (2.38e-4)" "unprognostic (2.64e-1)" "unprognostic (1.02e-1)" "unprognostic (6.87e-3)" "prognostic unfavorable (5.81e-8)" "unprognostic (1.35e-1)" "unprognostic (1.25e-1)" "unprognostic (3.99e-1)" "unprognostic (6.28e-2)" "unprognostic (1.85e-1)" "unprognostic (2.99e-2)" "unprognostic (8.43e-2)" "unprognostic (2.70e-1)" "unprognostic (4.06e-1)" "unprognostic (1.44e-2)" 29.8 33.9 10.6 31.1 11.2 40.6 33.1 12.5 13.3 30.7 12.9 36.5 22.7 34.9 21.9 29.8 33.5 20.6 47.4 10.9 10.6 33.6 32.1 22.7 46.9 10.5 11.7 33.5 45.2 29.3 22.0 30.2 10.9 23.8 35.4 10.3 25.7 22.3 345.1 22.2 28.8 41.1 10.0 33.5 28.0 29.2 10.5 50.5 29.6 242.3 48.5 36.0 25.2 10.8 98.0 110.2 88.3 124.9 62.6 89.5 106.5 82.0 85.2 187.3 138.1 189.0 51.9 279.0 73.2 102.3 84.9 67.3 203.5 137.4 187.7 75.3 197.5 126.5 98.4 166.5 134.6 423.0 96.3 97.7 76.5 161.5 169.8 91.3 138.9 127.3 153.1 114.3 136.4 105.0 130.2 131.2 152.5 121.3 119.3 195.1 203.6 198.2 118.9 67.8 58.8 54.4 106.2 54.1 170.7 78.5 76.8 134.7 91.2 93.3 173.7 85.3 168.8 109.0 212.6 218.2 80.9 149.5 97.7 29.0 47.2 19.9 35.5 55.2 49.5 34.6 76.1 48.5 68.1 33.5 58.3 45.0 4.1 48.2 49.7 34.4 81.7 62.3 10.6 11.2 12.5 13.3 10.9 10.6 10.5 11.7 10.9 10.0 10.5 10.8 10.0 12.8 10.8 9.4 28.3 18.1 18.8 48.6 23.9 16.1 14.8 15.0 30.0 30.0 20.8 3.7 37.5 85.3 15.5 13.0 7.9 61.3 44.0 5.6 9.2 21.6 13.8 54.6 11.4 43.7 78.9 21.2 21.4 5.6 36.8 8.8 28.9 25.6 60.3 6.7 10.7 24.1 24.4 44.8 26.7 25.2 24.8 22.7 12.4 1.0 41.9 45.1 19.6 9.5 9.8 33.7 15.6 14.3 52.4 21.3 21.4 19.7 12.3 18.1 26.3 38.5 20.8 61.2 82.8 35.7 15.2 33.1 32.2 8.7 37.7 14.1 ALAD "ALADH, PBGS" ENSG00000148218 "Aminolevulinate dehydratase" P13716 9 113386312-113401290 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Heme biosynthesis, Porphyrin biosynthesis" "Allosteric enzyme, Lyase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 209.8" "Cell type enhanced" "Detected in all" "Erythroid cells: 147.8;Granulosa cells: 86.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021023, HPA022124" Enhanced Approved Cytosol NA NA 44000000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 35: Non-specific - Unknown function" "Cluster 28: BEWO - Transcription regulation" "Cluster 6: Erythroid cells - Oxygen transport" Cytosol "HPA021023: AB_1844716, HPA022124: AB_1844717" "unprognostic (2.75e-1)" "unprognostic (6.26e-2)" "prognostic unfavorable (7.33e-5)" "prognostic favorable (5.64e-4)" "unprognostic (4.16e-2)" "unprognostic (9.49e-2)" "prognostic favorable (8.80e-5)" "unprognostic (2.87e-3)" "unprognostic (3.49e-1)" "unprognostic (2.95e-1)" "unprognostic (1.62e-1)" "unprognostic (3.31e-2)" "prognostic favorable (1.65e-4)" "unprognostic (1.75e-1)" "unprognostic (1.22e-1)" "unprognostic (3.40e-1)" "unprognostic (1.31e-2)" 54.7 153.9 73.5 16.8 82.7 82.2 23.2 75.2 84.7 18.4 53.6 25.7 29.5 16.3 26.6 35.0 15.6 27.4 51.9 66.0 74.5 73.2 209.8 20.6 15.6 85.4 83.5 28.9 46.5 73.2 15.9 24.9 84.5 34.1 24.5 19.0 98.6 24.2 28.8 38.9 26.6 17.6 80.1 13.6 50.4 13.1 81.1 20.3 25.9 23.9 18.7 18.4 19.3 83.7 8.1 14.8 11.0 15.7 71.2 48.4 67.8 21.9 35.4 13.7 17.2 19.2 16.7 11.7 12.7 30.3 11.0 29.1 8.1 14.6 8.3 29.5 10.2 22.0 18.2 26.2 16.4 21.2 19.0 41.2 10.8 12.7 5.5 53.9 27.1 18.6 8.9 16.5 23.7 61.8 23.8 21.2 5.4 57.9 27.4 19.5 18.7 19.8 21.4 16.6 10.2 9.4 27.2 32.5 20.1 19.2 34.1 23.7 30.7 12.5 9.3 25.1 12.4 23.8 26.0 9.8 34.1 18.9 13.6 10.2 13.7 23.6 11.3 15.5 6.0 6.8 9.3 6.0 14.6 10.2 8.7 9.9 6.2 6.9 17.4 6.0 10.8 9.7 73.5 82.7 75.2 84.7 66.0 74.5 85.4 83.5 84.5 80.1 81.1 83.7 7.2 16.0 15.6 18.6 10.4 7.0 8.9 7.1 8.0 12.9 16.7 11.6 50.3 25.8 12.0 14.7 27.1 48.2 7.4 27.7 13.7 20.3 5.4 17.7 9.2 11.5 9.1 147.8 10.0 26.3 23.2 10.2 15.3 27.7 14.5 86.5 11.0 70.0 17.0 5.0 10.7 12.5 10.2 15.1 6.4 10.8 11.8 12.4 12.4 9.4 12.4 6.4 8.2 7.1 20.0 15.0 35.3 14.7 11.0 7.6 32.6 59.0 10.6 15.7 6.6 8.9 24.6 6.8 9.5 22.6 9.1 11.4 8.8 11.7 16.7 9.2 ALDOA ENSG00000149925 "Aldolase, fructose-bisphosphate A" P04075 16 30064164-30070457 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Glycolysis Lyase "Cancer-related genes, Disease variant, Glycogen storage disease, Hereditary hemolytic anemia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 8 "skeletal muscle: 26754.8;tongue: 9180.4" "Cell type enhanced" "Detected in all" "Basal respiratory cells: 3267.9;Extravillous trophoblasts: 2322.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004177, CAB006252" Supported Approved Cytosol NA NA 640000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 25: RPMI-8226 - Immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Cytosol "CAB006252: AB_437007, HPA004177: AB_1078128" "unprognostic (2.63e-2)" "unprognostic (3.22e-2)" "unprognostic (6.80e-2)" "unprognostic (1.33e-1)" "unprognostic (6.74e-3)" "unprognostic (4.28e-3)" "prognostic unfavorable (5.79e-5)" "prognostic unfavorable (7.32e-5)" "unprognostic (1.68e-1)" "unprognostic (1.81e-1)" "unprognostic (2.30e-2)" "unprognostic (1.57e-1)" "unprognostic (1.81e-1)" "unprognostic (1.28e-1)" "unprognostic (1.22e-1)" "unprognostic (2.19e-3)" "unprognostic (4.48e-2)" 569.3 696.4 616.8 443.1 697.4 732.5 512.6 617.3 719.7 566.0 617.0 774.1 517.9 533.7 201.0 1302.0 449.7 420.5 2286.1 731.9 652.0 709.0 217.1 425.6 358.2 762.3 654.0 510.4 390.5 943.1 525.1 351.4 763.9 457.7 400.1 465.2 904.9 597.6 26754.8 643.4 488.3 465.2 545.5 417.5 595.0 138.7 657.8 280.9 454.5 9180.4 478.3 761.8 740.3 558.7 2206.1 1620.4 477.9 1542.8 714.6 808.5 1520.8 1297.9 1336.2 1291.6 1603.0 1158.1 1643.6 1487.6 2072.2 1318.6 708.6 1632.6 966.8 2829.1 939.3 658.5 1272.9 1219.3 1202.7 2591.1 1112.5 1793.8 1251.3 1115.7 979.6 1455.4 968.9 2119.7 965.4 686.9 1070.0 951.1 1393.4 3136.7 1100.2 1477.0 1192.8 848.1 1346.6 1613.9 765.2 3353.2 1629.4 1230.5 950.7 668.5 808.6 3368.5 1213.9 591.2 1433.0 1194.7 1162.5 1892.3 750.3 1046.7 1430.0 1861.5 1387.3 1369.3 3524.5 1715.9 1532.9 2050.6 2694.7 2081.7 1008.7 2466.5 1138.1 908.5 1091.7 1047.0 2182.7 877.9 1027.4 996.9 2531.7 819.9 2780.2 824.0 1476.3 4372.2 616.8 697.4 617.3 719.7 731.9 652.0 762.3 654.0 763.9 545.5 657.8 558.7 17.0 12.8 32.4 83.2 281.2 792.0 716.4 3267.9 784.8 387.4 34.4 21.6 1968.4 273.1 1385.1 42.3 118.9 1194.1 107.9 1834.8 111.6 120.9 258.8 15.8 11.8 261.1 323.9 215.8 66.2 76.2 2322.1 329.7 513.3 16.1 196.5 18.7 289.5 102.0 1181.9 733.6 70.0 755.1 1265.4 632.2 715.4 1152.4 380.8 388.8 924.9 50.6 417.7 662.1 328.5 40.2 60.8 126.2 1497.1 405.1 409.4 676.9 1755.7 75.8 700.9 298.9 486.4 680.9 572.9 25.8 123.6 1174.6 684.5 1361.3 294.3 15.2 937.7 1146.2 ALDOB ENSG00000136872 "Aldolase, fructose-bisphosphate B" P05062 9 101420560-101449664 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Glycolysis Lyase "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 27 "intestine: 5736.6;kidney: 7181.0;liver: 11160.8" "Group enriched" "Detected in some" 4 "Proximal enterocytes: 20078.3;Proximal tubular cells: 7956.0" "Cancer enriched" "Detected in many" 31 "liver cancer: 1414.0" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 21.4;NB-4: 21.0;RPMI-8226: 28.6;SH-SY5Y: 20.6" "Not detected" "Not detected" "Low region specificity" "Detected in some" "HPA002198, CAB020827" Enhanced NA NA 560000000 "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 24: NB-4 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "CAB020827: , HPA002198: AB_1078129" "unprognostic (6.58e-3)" "unprognostic (2.83e-1)" "unprognostic (1.43e-3)" "unprognostic (1.03e-1)" "unprognostic (8.10e-2)" "unprognostic (1.96e-2)" "unprognostic (1.44e-3)" "unprognostic (4.34e-2)" "unprognostic (4.57e-2)" "unprognostic (2.66e-1)" "unprognostic (5.79e-2)" "unprognostic (7.48e-2)" "unprognostic (1.66e-2)" "unprognostic (2.02e-1)" "unprognostic (2.58e-1)" "unprognostic (5.19e-2)" "unprognostic (1.96e-2)" 3.3 1.4 0.4 17.0 0.7 0.0 0.7 1.0 2.3 0.2 0.0 30.1 4073.8 2.8 1.0 0.7 0.4 176.9 1.0 2.4 0.0 7181.0 11160.8 0.5 4.9 0.0 0.0 0.5 292.7 0.0 5.6 0.4 0.0 2.1 5.6 0.3 0.3 0.0 0.4 0.5 5736.6 7.0 0.0 2.0 34.3 1.1 0.0 0.7 0.3 0.0 0.8 0.1 0.3 0.3 0.0 0.0 0.1 0.0 0.0 0.0 21.4 0.0 0.0 0.0 0.0 0.5 0.0 4.5 1.8 0.0 0.0 0.6 0.0 0.0 0.0 0.4 0.0 2.2 0.0 1.0 0.0 6.1 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.0 0.3 0.0 0.0 0.3 21.0 0.4 0.5 0.0 0.3 4.6 28.6 0.0 0.0 4.3 20.6 2.0 0.0 0.0 0.0 0.0 0.1 1.9 0.1 1.0 7.1 0.3 0.5 0.7 2.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.7 1.0 2.3 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.3 39.4 0.0 0.0 0.3 0.0 1.1 0.0 0.0 1.1 308.8 0.8 150.8 0.0 0.0 0.0 13.5 620.3 4.9 0.0 0.0 0.4 3.6 0.0 50.8 0.5 253.3 0.1 0.0 0.0 0.3 0.0 0.0 49.2 3225.4 0.2 3.3 0.2 464.9 0.0 66.2 0.0 0.0 0.0 38.1 0.0 0.0 3.6 0.3 0.0 0.0 0.3 182.1 997.4 0.0 0.1 0.0 20078.3 7956.0 0.2 0.6 0.0 0.4 1.6 0.0 0.0 0.0 0.0 0.3 20.6 0.2 412.7 0.0 ALDOC ENSG00000109107 "Aldolase, fructose-bisphosphate C" P09972 17 28573115-28576948 "Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Glycolysis Lyase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 1384.6;choroid plexus: 589.6;retina: 1183.1" "Cell type enhanced" "Detected in many" "Bipolar cells: 112.5;Horizontal cells: 274.2;Muller glia cells: 127.1;Proximal enterocytes: 120.0;Rod photoreceptor cells: 348.5" "Cancer enriched" "Detected in all" 6 "glioma: 128.9" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "RPMI-8226: 250.9;U-266/70: 161.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003282, CAB020828, HPA067442" Enhanced Supported Approved "Nucleoplasm,Nucleoli fibrillar center,Vesicles,Cytosol" Yes No 150000000 "Cluster 20: T-cells - T-cell receptor" "Cluster 77: Retina - Visual perception" "Cluster 25: RPMI-8226 - Immune response" "Cluster 46: Photoreceptor cells - Phototransduction" "Nucleoplasm, Nucleoli fibrillar center" "Vesicles, Cytosol" "CAB020828: , HPA003282: AB_1078130, HPA067442: " "unprognostic (2.90e-1)" "unprognostic (4.45e-3)" "unprognostic (5.69e-3)" "unprognostic (1.43e-1)" "unprognostic (3.56e-1)" "prognostic unfavorable (9.80e-4)" "unprognostic (1.03e-1)" "unprognostic (1.70e-1)" "unprognostic (1.30e-1)" "unprognostic (6.03e-3)" "unprognostic (3.90e-1)" "unprognostic (3.24e-2)" "prognostic unfavorable (1.29e-7)" "unprognostic (1.28e-1)" "unprognostic (2.00e-1)" "unprognostic (2.74e-2)" "unprognostic (1.23e-1)" 87.0 24.3 953.6 12.7 909.7 23.6 42.5 1238.3 1162.3 39.3 589.6 18.5 18.7 17.9 10.9 40.8 14.3 10.9 285.5 955.7 958.0 16.8 98.3 13.7 19.3 1297.5 962.6 39.1 4.9 12.1 30.6 4.1 1384.6 18.9 14.7 1183.1 19.9 15.8 4.8 74.5 43.9 12.4 926.9 24.4 23.3 14.2 1090.2 9.6 7.4 8.1 30.5 19.0 47.0 886.1 29.9 2.1 13.7 55.7 29.9 32.9 2.9 16.7 37.7 12.9 76.0 17.9 3.0 14.9 17.3 15.5 3.3 36.9 10.3 102.3 23.4 12.4 8.9 28.3 11.6 30.4 25.8 10.0 29.2 27.8 13.9 1.5 24.0 1.7 5.3 29.7 19.3 71.9 10.7 15.1 11.9 32.0 20.8 6.7 15.3 9.5 1.6 250.9 1.9 4.3 36.2 61.9 9.1 67.3 0.5 20.8 36.6 21.2 3.5 1.2 5.3 2.1 2.4 161.0 51.4 10.9 105.2 28.0 1.9 0.5 7.4 3.0 21.6 8.7 30.6 24.0 29.5 17.8 9.4 25.1 37.7 28.4 18.0 29.4 5.3 4.6 40.9 19.0 953.6 909.7 1238.3 1162.3 955.7 958.0 1297.5 962.6 1384.6 926.9 1090.2 886.1 4.2 0.0 15.8 97.6 9.8 7.5 20.3 80.5 8.6 112.5 9.0 11.0 22.1 11.5 29.3 7.3 106.3 1.1 9.5 31.7 3.9 21.9 0.9 1.0 3.0 11.3 21.6 3.2 19.2 10.2 6.5 5.8 6.6 1.2 13.3 4.9 14.3 93.1 5.4 274.2 41.3 12.9 28.5 4.4 5.3 1.3 9.3 3.1 24.9 21.5 34.1 127.1 12.3 26.7 16.8 12.4 12.4 10.1 2.6 6.1 120.0 2.1 11.8 348.5 13.1 6.4 10.1 0.3 3.2 7.9 10.9 1.5 17.0 11.7 5.1 7.8 ALKBH1 "ABH, alkB, ALKBH, hABH" ENSG00000100601 "AlkB homolog 1, histone H2A dioxygenase" Q13686 14 77672404-77708023 "Enzymes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, RNA repair, Translation regulation" "Dioxygenase, Lyase, Multifunctional enzyme, Oxidoreductase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA044087, HPA060061" Approved Supported "Nucleoplasm,Endoplasmic reticulum" "Intracellular and membrane" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm "Endoplasmic reticulum" "HPA044087: AB_2678803, HPA060061: " "unprognostic (1.92e-2)" "unprognostic (8.38e-2)" "unprognostic (1.32e-1)" "unprognostic (1.37e-3)" "unprognostic (3.41e-2)" "unprognostic (5.03e-2)" "unprognostic (3.74e-3)" "unprognostic (7.45e-3)" "unprognostic (2.68e-2)" "unprognostic (3.95e-2)" "unprognostic (5.05e-3)" "unprognostic (2.16e-2)" "prognostic favorable (1.80e-4)" "unprognostic (1.65e-3)" "unprognostic (1.46e-1)" "unprognostic (2.63e-1)" "unprognostic (2.44e-2)" 2.7 2.7 2.8 1.8 3.2 1.2 3.5 3.9 3.5 3.4 2.7 2.8 2.5 2.3 2.1 2.6 2.9 2.2 4.1 3.0 3.5 3.0 3.6 2.2 3.5 2.8 3.2 2.9 2.6 3.3 1.5 3.9 2.9 3.1 3.4 2.9 2.1 3.1 5.7 2.6 2.1 2.9 3.0 2.3 2.5 3.0 3.2 4.4 3.1 7.4 4.1 3.1 2.2 3.3 5.2 7.5 6.0 4.1 6.3 6.8 7.4 5.3 6.8 11.3 12.7 7.7 3.1 7.9 2.9 4.8 5.3 4.5 13.2 5.7 13.2 5.4 5.1 4.2 4.0 6.4 8.9 4.5 2.6 5.8 9.2 6.6 10.5 5.0 9.4 6.1 6.6 4.4 6.1 8.1 6.0 5.7 6.6 7.7 9.6 6.0 6.0 5.3 6.4 4.5 7.6 5.7 4.3 4.5 5.7 4.9 10.9 4.5 4.3 4.7 4.7 5.2 4.3 5.4 9.4 7.6 3.2 6.3 4.7 10.7 3.0 1.4 2.9 3.5 2.4 3.4 2.7 2.8 3.0 2.7 2.8 2.2 0.8 3.6 2.4 1.6 3.3 2.2 2.8 3.2 3.9 3.5 3.0 3.5 2.8 3.2 2.9 3.0 3.2 3.3 6.5 0.0 3.9 13.1 7.3 8.4 5.7 6.2 6.8 4.1 5.4 4.4 7.5 1.5 4.5 1.8 2.1 9.9 3.5 4.2 9.8 6.2 4.8 4.4 4.5 5.7 2.4 4.2 15.9 7.0 8.8 5.5 2.6 3.8 9.5 6.1 2.2 3.9 7.6 0.0 15.8 4.9 6.1 5.2 5.0 4.2 6.5 7.7 5.4 5.6 6.6 7.8 4.1 16.1 19.4 6.8 1.5 5.3 4.9 4.5 7.0 6.5 5.5 5.3 6.6 4.2 5.6 21.1 15.9 4.4 5.4 12.2 5.6 5.1 4.8 3.7 ALOXE3 "E-LOX, eLOX3" ENSG00000179148 "Arachidonate lipoxygenase 3" Q9BYJ1 17 8095900-8119047 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" "Dioxygenase, Isomerase, Lyase, Oxidoreductase" "Disease variant, Ichthyosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 27 "skin 1: 56.2" "Cell type enhanced" "Detected in some" "Basal prostatic cells: 2.1;Pancreatic endocrine cells: 6.3;Prostatic glandular cells: 1.8;Spermatocytes: 1.8;Spermatogonia: 1.7;Suprabasal keratinocytes: 1.8" "Group enriched" "Detected in some" 4 "cervical cancer: 1.1;head and neck cancer: 3.9;melanoma: 1.5" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 6.4;HBEC3-KT: 10.1;hTCEpi: 7.3;hTERT-HME1: 13.7;T-47d: 4.4" "Low region specificity" "Detected in many" "Not detected" "Not detected" "HPA023120, HPA078597" Enhanced Approved "Plasma membrane,Cytosol" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 61: Skin - Cornification" "Cluster 30: Epithelial cell lines - Translation" "Cluster 16: Pancreatic endocrine cells - Mixed function" "Plasma membrane, Cytosol" "HPA023120: AB_10959300, HPA078597: AB_2732385" "unprognostic (2.40e-1)" "unprognostic (3.01e-2)" "unprognostic (1.87e-3)" "unprognostic (2.09e-4)" "unprognostic (1.07e-2)" "unprognostic (4.06e-2)" "unprognostic (3.56e-4)" "unprognostic (3.60e-1)" "unprognostic (4.65e-2)" "unprognostic (3.82e-2)" "unprognostic (3.72e-1)" "unprognostic (3.66e-5)" "unprognostic (9.81e-2)" "unprognostic (2.55e-1)" "unprognostic (1.08e-2)" "unprognostic (2.88e-2)" 0.0 0.0 0.5 0.0 0.3 0.0 1.6 1.9 2.1 0.6 0.0 0.0 0.0 0.0 0.1 0.7 0.0 0.0 0.0 0.7 0.4 0.0 0.0 0.0 0.0 0.8 0.7 0.0 0.1 0.4 0.2 0.1 0.7 0.1 0.0 0.1 0.3 0.0 0.1 56.2 0.0 0.0 0.1 0.0 0.0 0.8 1.0 0.0 0.0 0.0 1.2 0.0 1.8 0.5 6.4 0.7 0.0 0.0 0.0 0.0 0.0 0.4 0.4 0.0 0.4 0.1 0.5 0.2 0.2 0.1 2.9 0.4 0.8 10.1 0.1 0.0 0.3 0.0 0.2 0.0 0.0 0.0 0.0 0.0 7.3 0.1 13.7 0.0 0.0 0.9 0.0 0.1 0.0 2.3 0.0 0.0 0.0 0.2 2.0 0.0 0.0 0.0 0.1 0.3 0.0 0.1 0.0 0.7 0.0 0.0 4.4 0.0 0.1 0.0 2.1 0.0 0.3 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.3 1.9 2.1 0.7 0.4 0.8 0.7 0.7 0.1 1.0 0.5 0.1 0.0 0.0 0.0 0.0 0.3 2.1 1.2 0.0 0.0 0.6 0.5 0.5 0.0 0.2 0.0 0.0 0.0 0.1 0.1 0.0 0.4 0.4 0.1 0.1 0.2 0.0 0.0 1.2 0.9 1.2 0.1 0.0 1.1 0.0 0.0 0.0 0.0 0.1 0.0 1.2 0.2 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 6.3 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.2 1.8 1.7 0.3 1.8 1.1 0.0 0.0 0.0 0.6 AMD1 SAMDC ENSG00000123505 "Adenosylmethionine decarboxylase 1" P17707 6 110874770-110898879 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Polyamine biosynthesis, Spermidine biosynthesis" "Decarboxylase, Lyase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "prostate: 202.9" "Low cell type specificity" "Detected in all" "Cancer enhanced" "Detected in all" "prostate cancer: 70.4" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029281, HPA029282" Approved Approved Nucleoplasm NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 18: U-2197 - ECM organization" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "HPA029281: AB_10600101, HPA029282: AB_10599965" "prognostic unfavorable (3.87e-4)" "unprognostic (4.68e-2)" "unprognostic (1.85e-3)" "unprognostic (1.01e-1)" "unprognostic (2.01e-1)" "unprognostic (1.05e-1)" "prognostic unfavorable (1.91e-6)" "unprognostic (1.18e-1)" "unprognostic (2.03e-2)" "unprognostic (6.50e-2)" "unprognostic (2.25e-1)" "unprognostic (4.20e-1)" "prognostic favorable (4.28e-4)" "unprognostic (8.62e-3)" "unprognostic (1.55e-1)" "unprognostic (4.41e-2)" "unprognostic (7.71e-2)" 31.8 28.3 35.0 34.7 44.9 89.9 33.9 39.6 56.1 32.8 32.0 36.9 29.2 35.5 25.7 56.0 25.6 33.3 40.2 37.5 38.2 48.6 33.6 33.4 39.9 45.6 38.5 30.0 39.7 40.3 26.0 59.9 42.2 202.9 36.5 35.9 37.4 34.5 26.7 26.9 26.5 35.4 45.5 27.3 31.2 31.9 37.6 40.5 46.2 50.2 50.3 37.4 25.8 67.1 85.8 57.4 68.6 130.6 101.1 63.9 89.8 119.9 131.8 91.4 106.7 92.2 52.3 149.7 56.7 76.7 97.0 57.4 163.9 108.6 125.1 88.5 94.6 155.4 47.5 96.5 60.2 135.7 88.9 43.4 98.0 63.4 126.4 31.8 81.0 75.4 118.2 126.8 156.3 51.8 181.9 103.3 84.7 84.1 51.9 98.5 68.9 89.3 103.9 112.9 87.4 62.2 73.2 91.7 110.7 55.5 59.5 114.9 53.8 60.5 45.7 325.0 131.5 34.4 59.7 152.8 69.6 106.7 79.4 42.9 23.9 37.7 17.4 28.9 20.2 14.5 17.4 20.3 31.5 14.8 20.4 20.8 102.6 15.5 37.3 13.9 22.5 17.0 35.0 44.9 39.6 56.1 37.5 38.2 45.6 38.5 42.2 45.5 37.6 67.1 169.5 38.5 92.5 23.2 164.8 315.3 241.5 49.5 262.4 101.4 178.5 151.1 95.7 125.8 82.7 55.2 60.5 44.5 208.7 144.1 146.8 67.2 31.8 145.0 106.2 104.4 124.4 184.1 39.2 70.0 152.0 132.1 96.4 214.8 93.9 36.9 53.6 59.3 77.0 77.4 37.9 108.2 28.5 109.1 244.2 53.6 43.8 176.7 131.6 23.4 92.0 303.7 60.8 36.7 111.6 87.6 95.9 50.0 118.9 379.4 66.2 89.9 29.3 105.6 19.7 170.5 124.9 93.0 76.7 246.4 288.1 54.6 184.6 45.7 128.8 147.7 APIP "APIP2, CGI-29, Mmrp19" ENSG00000149089 "APAF1 interacting protein" Q96GX9 11 34853094-34916379 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Amino-acid biosynthesis, Apoptosis, Methionine biosynthesis" Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal tubular cells: 187.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021188, HPA024131" Approved Approved Nucleoplasm,Cytosol NA NA 52000 "Cluster 27: Non-specific - Gene expression" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 30: Mammary glandular cells - Lactation" Nucleoplasm Cytosol "HPA021188: AB_10610977, HPA024131: AB_10602171" "unprognostic (2.80e-1)" "unprognostic (7.68e-2)" "unprognostic (5.30e-2)" "unprognostic (3.68e-3)" "unprognostic (4.22e-2)" "unprognostic (1.76e-1)" "prognostic unfavorable (1.99e-4)" "unprognostic (2.74e-2)" "unprognostic (3.84e-2)" "unprognostic (9.16e-2)" "unprognostic (2.45e-2)" "unprognostic (1.68e-1)" "unprognostic (1.51e-1)" "unprognostic (3.23e-1)" "unprognostic (5.48e-2)" "unprognostic (7.44e-2)" "unprognostic (1.58e-2)" 30.4 25.4 14.7 20.7 17.1 14.4 20.7 17.3 17.1 18.0 14.2 19.9 13.6 15.0 15.0 13.8 17.2 18.5 20.0 13.9 16.3 27.0 19.4 21.2 20.2 18.7 16.4 12.3 17.2 15.8 9.1 13.3 18.4 16.8 19.5 16.8 31.7 23.6 65.6 10.0 16.3 12.3 17.1 15.5 18.8 10.7 16.0 31.3 24.6 38.3 16.3 19.1 9.6 20.9 25.1 27.3 33.5 8.3 27.7 26.8 14.5 36.8 38.0 38.9 44.4 15.6 21.3 77.1 21.7 15.5 40.3 28.8 56.1 24.9 53.3 49.9 56.3 39.5 27.8 42.6 41.2 111.3 28.9 23.6 20.6 22.1 40.7 19.1 29.8 49.8 94.2 45.2 27.6 24.2 59.7 57.7 25.1 39.6 61.7 36.4 89.1 29.6 46.8 36.3 28.5 13.6 45.0 37.2 50.2 17.4 38.9 34.3 24.1 29.2 26.9 68.1 9.0 43.9 36.1 89.4 32.2 27.3 37.2 11.3 27.3 25.4 17.2 30.0 21.3 24.5 21.1 18.8 42.7 24.3 21.4 18.3 6.7 31.4 36.8 27.2 27.2 18.4 14.7 17.1 17.3 17.1 13.9 16.3 18.7 16.4 18.4 17.1 16.0 20.9 24.7 35.3 30.1 42.4 27.9 25.0 37.5 62.7 19.4 28.8 73.8 36.2 23.1 37.1 63.0 18.4 4.2 37.2 25.5 49.5 187.9 30.2 8.0 33.4 23.9 22.8 35.5 42.5 28.4 32.4 23.4 24.4 29.6 24.8 20.3 22.0 21.0 26.0 76.5 18.5 35.2 41.3 87.5 47.1 31.8 8.3 23.9 47.6 21.4 17.8 59.4 23.1 25.7 51.3 108.8 25.4 28.4 24.8 44.2 33.0 35.0 101.7 56.8 21.6 39.5 37.8 30.1 32.4 22.3 31.4 26.3 26.4 25.8 27.1 50.1 50.4 ASL ASAL ENSG00000126522 "Argininosuccinate lyase" P04424 7 66075800-66094697 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Amino-acid biosynthesis, Arginine biosynthesis, Urea cycle" Lyase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 6 "liver: 396.4" "Cell type enhanced" "Detected in all" "Distal enterocytes: 294.6;Exocrine glandular cells: 218.6;Hepatocytes: 578.0;Paneth cells: 240.4;Proximal enterocytes: 259.9;Proximal tubular cells: 243.1" "Cancer enhanced" "Detected in all" "liver cancer: 52.7" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003696, HPA016646" Enhanced Approved Cytosol NA NA 12000000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 85: Liver - Metabolism" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "CAB003696: AB_425316, HPA016646: AB_1845096" "unprognostic (2.95e-2)" "prognostic unfavorable (4.05e-6)" "unprognostic (4.83e-1)" "unprognostic (4.18e-3)" "unprognostic (3.52e-2)" "unprognostic (1.21e-1)" "unprognostic (1.98e-1)" "unprognostic (2.07e-1)" "unprognostic (7.28e-2)" "unprognostic (2.49e-2)" "unprognostic (7.25e-2)" "unprognostic (4.95e-2)" "unprognostic (2.07e-2)" "unprognostic (3.69e-1)" "unprognostic (1.45e-1)" "unprognostic (2.19e-1)" "unprognostic (8.40e-3)" 21.7 16.1 5.9 16.7 6.0 23.9 22.0 6.6 8.5 18.2 8.7 53.8 60.7 17.0 6.7 28.7 18.1 27.7 16.9 5.9 8.0 61.2 396.4 27.4 10.3 7.4 7.1 19.7 37.1 15.1 19.8 9.1 9.8 19.5 35.7 2.4 18.3 9.8 8.7 15.1 45.6 10.1 6.2 30.5 43.9 4.5 7.6 5.3 24.9 6.9 8.8 19.3 19.8 6.7 48.4 18.9 11.2 36.7 26.3 18.1 22.1 34.0 31.8 49.5 43.6 43.7 59.0 15.9 53.7 48.5 36.6 13.4 7.1 59.1 11.1 10.5 8.9 18.8 17.9 77.2 48.8 24.0 51.3 38.3 19.5 31.8 51.8 12.5 48.1 11.3 34.4 27.8 25.4 36.6 4.8 28.9 15.8 65.5 26.1 12.1 11.0 51.6 31.9 31.6 18.4 24.3 32.3 109.7 12.3 11.4 46.0 19.7 55.1 53.7 30.8 23.5 45.2 30.2 16.9 19.0 55.0 41.5 49.5 34.2 42.6 50.8 16.9 46.6 15.1 21.8 11.5 13.4 46.2 13.8 8.2 8.5 7.3 73.7 36.1 2.5 23.4 27.3 5.9 6.0 6.6 8.5 5.9 8.0 7.4 7.1 9.8 6.2 7.6 6.7 34.5 19.2 61.4 5.2 20.4 5.5 21.4 24.2 9.1 12.7 24.5 20.4 9.2 124.4 25.8 31.3 22.9 20.7 25.4 294.6 52.8 73.7 4.0 41.2 12.1 30.7 54.0 47.1 9.4 218.6 45.7 14.4 115.7 34.1 44.5 12.0 42.8 578.0 46.0 15.2 9.7 126.5 16.2 41.2 17.6 6.3 9.3 22.3 8.8 1.9 48.3 7.2 34.0 2.5 4.8 118.3 240.4 8.2 23.4 14.9 259.9 243.1 42.8 13.2 13.1 16.9 17.5 3.2 5.7 19.5 4.3 22.3 18.0 13.5 189.4 22.0 AUH ENSG00000148090 "AU RNA binding methylglutaconyl-CoA hydratase" Q13825 9 91213815-91361918 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Branched-chain amino acid catabolism" "Lyase, RNA-binding" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal tubular cells: 191.7;Inhibitory neurons: 137.0;Oligodendrocytes: 137.5;Proximal tubular cells: 120.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 82.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004171 Enhanced "Intracellular and membrane" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 1: Thyroid gland - Transcription" "Cluster 44: HDLM-2 - Immune response" "Cluster 39: Non-specific - Basic cellular processes" "HPA004171: AB_1845215" "unprognostic (4.10e-2)" "unprognostic (8.95e-2)" "unprognostic (5.56e-2)" "unprognostic (1.19e-1)" "unprognostic (1.54e-1)" "unprognostic (1.49e-1)" "unprognostic (3.24e-2)" "unprognostic (3.05e-2)" "unprognostic (3.57e-1)" "unprognostic (1.11e-3)" "unprognostic (1.41e-1)" "unprognostic (1.76e-1)" "prognostic favorable (0.00e+0)" "unprognostic (8.23e-3)" "unprognostic (2.84e-2)" "unprognostic (1.23e-1)" "unprognostic (1.23e-1)" 17.2 41.9 11.8 6.3 12.3 4.8 15.9 16.0 15.3 13.6 17.9 17.2 23.8 10.2 14.2 8.6 12.4 10.7 38.9 12.1 14.3 62.9 26.4 10.3 7.6 14.8 13.6 13.4 25.5 45.4 10.4 16.1 15.2 28.2 17.2 21.4 26.1 14.8 24.2 8.7 20.1 8.6 12.2 8.0 22.7 5.5 14.1 9.0 21.0 29.2 7.7 9.1 9.8 15.0 9.1 8.7 12.0 6.2 14.5 15.5 18.5 8.0 10.0 6.1 7.0 5.0 11.4 10.6 8.1 8.5 18.2 13.0 18.1 10.1 8.7 82.6 15.4 7.3 9.7 29.6 11.1 10.6 7.3 13.1 12.5 4.9 16.8 14.3 7.6 10.7 10.3 15.5 7.2 8.8 14.6 23.8 15.0 22.2 12.5 8.5 9.6 18.6 26.6 4.8 12.2 8.8 11.9 28.3 15.6 27.1 5.2 6.9 7.8 6.1 7.6 9.0 7.8 17.7 16.1 3.6 9.6 8.5 4.2 17.9 5.2 18.2 7.2 3.6 8.1 8.4 7.8 10.4 4.6 11.8 9.6 9.1 7.4 10.8 2.5 6.3 10.8 6.5 11.8 12.3 16.0 15.3 12.1 14.3 14.8 13.6 15.2 12.2 14.1 15.0 9.6 0.0 7.7 75.1 11.2 5.2 24.5 27.7 12.5 18.7 15.8 13.5 37.2 27.1 19.1 27.6 25.0 44.6 11.5 27.0 191.7 29.6 3.1 11.5 11.1 11.1 22.9 28.8 101.2 16.1 28.9 14.2 19.4 16.0 1.3 14.5 11.0 18.3 13.4 13.5 137.0 17.3 38.7 8.9 4.7 1.1 14.3 8.9 12.4 67.5 29.1 9.5 18.6 100.5 137.5 12.5 23.5 11.3 18.4 36.8 59.4 120.0 15.8 34.4 13.1 11.9 11.5 8.7 10.5 16.1 4.1 36.4 12.9 11.6 25.0 24.2 CA1 Car1 ENSG00000133742 "Carbonic anhydrase 1" P00915 8 85327608-85379014 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 55 "bone marrow: 1798.9;intestine: 2109.9" "Cell type enriched" "Detected in some" 4 "Erythroid cells: 11487.3" "Group enriched" "Detected in some" 10 "colorectal cancer: 3.4;stomach cancer: 0.9" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 987 "HEL: 1022.7" "Not detected" "Not detected" "Not detected" "Not detected" "HPA006558, CAB025790" Enhanced NA NA 4600000000 "Cluster 43: B-cells - Humoral immune response" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 36: HEL - Hemostasis" "Cluster 6: Erythroid cells - Oxygen transport" "CAB025790: , HPA006558: AB_1845989" "unprognostic (1.44e-1)" "unprognostic (7.56e-2)" "unprognostic (1.70e-1)" "unprognostic (3.57e-3)" "unprognostic (2.08e-2)" "unprognostic (1.66e-1)" "unprognostic (2.84e-2)" "unprognostic (2.03e-2)" "unprognostic (1.73e-2)" "unprognostic (6.12e-2)" "unprognostic (1.63e-1)" "unprognostic (1.04e-1)" "unprognostic (5.61e-2)" "unprognostic (3.01e-2)" "unprognostic (2.38e-1)" "unprognostic (3.95e-2)" 2.0 0.4 0.4 0.5 0.3 1798.9 2.1 1.0 1.5 0.3 0.0 1023.3 0.2 1.6 0.1 0.7 2.2 0.3 1.6 0.2 0.2 2.0 6.7 5.9 0.2 0.3 0.3 0.4 0.3 0.1 1.9 20.7 0.3 0.4 2109.9 0.4 1.1 1.8 1.0 1.4 1.8 30.7 0.1 35.4 2.3 0.2 0.5 0.5 0.9 3.4 0.1 0.4 0.5 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1022.7 0.0 0.5 0.0 0.2 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.8 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 2.8 0.4 0.3 1.0 1.5 0.2 0.2 0.3 0.3 0.3 0.1 0.5 0.6 0.0 0.0 0.0 4.2 11.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 2.8 0.0 0.0 0.0 0.0 0.0 2565.3 0.0 0.0 0.5 0.1 0.0 0.5 45.8 11487.3 11.8 0.0 0.0 0.1 0.0 0.1 22.3 0.0 4.2 4.4 0.0 0.0 12.1 159.4 0.0 11.4 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 1.0 13.0 2.2 0.0 754.9 0.0 0.1 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 3.4 0.1 298.4 0.0 CA12 HsT18816 ENSG00000074410 "Carbonic anhydrase 12" O43570 15 63321378-63381846 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins" Lyase "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 290.2;skin 1: 142.1" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 174.6;Distal enterocytes: 422.6;Paneth cells: 160.8;Squamous epithelial cells: 185.3;Suprabasal keratinocytes: 252.2;Undifferentiated cells: 138.8" "Cancer enhanced" "Detected in all" "renal cancer: 109.3" "Region enhanced" "Detected in many" "basal ganglia: 42.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 213.0;ASC TERT1: 213.0;RT4: 226.2;SK-BR-3: 177.9;T-47d: 286.8;U-138 MG: 300.5;U-87 MG: 361.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008773, CAB025181, CAB062549, CAB068179, HPA073203" Enhanced NA NA 52000 "Cluster 7: Kidney - Transmembrane transport" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB025181: , CAB062549: AB_2665617, CAB068179: AB_2665616, HPA008773: AB_1078394, HPA073203: AB_2686580" "unprognostic (2.01e-1)" "unprognostic (8.38e-3)" "unprognostic (3.47e-1)" "unprognostic (3.25e-3)" "unprognostic (2.73e-2)" "unprognostic (2.47e-2)" "unprognostic (7.48e-2)" "unprognostic (3.43e-3)" "unprognostic (2.29e-1)" "unprognostic (4.67e-2)" "prognostic unfavorable (3.80e-6)" "unprognostic (2.59e-1)" "unprognostic (1.51e-1)" "unprognostic (2.38e-1)" "unprognostic (6.56e-2)" "unprognostic (7.26e-2)" "unprognostic (1.21e-1)" 8.3 0.2 6.1 18.7 42.9 0.1 42.8 5.2 7.2 50.7 129.0 104.1 0.4 28.4 4.1 75.4 25.0 7.7 3.2 6.8 6.6 290.2 0.7 3.0 0.3 0.9 9.6 0.6 70.2 0.3 10.7 2.3 3.2 5.5 94.2 1.9 26.3 8.7 0.6 142.1 8.2 56.2 0.9 0.8 7.9 0.6 16.1 0.1 4.6 0.1 8.7 27.4 49.0 1.5 0.0 213.0 3.5 0.5 27.3 213.0 11.2 15.7 13.7 2.5 4.1 1.6 0.5 0.0 51.4 12.6 81.7 1.1 0.0 10.4 6.2 0.3 7.7 0.0 13.9 0.4 0.6 0.0 0.3 81.3 11.4 63.6 20.4 0.1 2.7 0.1 0.0 0.3 2.8 125.2 0.3 0.2 3.4 0.0 33.4 0.1 0.0 0.1 0.2 226.2 1.8 0.2 0.9 177.9 0.0 2.1 286.8 0.1 0.4 300.5 16.0 10.1 0.2 0.0 0.0 0.1 361.6 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.1 42.9 5.2 7.2 6.8 6.6 0.9 9.6 3.2 0.9 16.1 1.5 0.7 0.0 6.9 11.4 1.1 174.6 20.0 87.7 93.4 0.1 93.5 50.4 1.3 1.5 30.3 40.5 0.0 0.4 1.6 422.6 54.8 17.2 12.1 28.4 6.2 2.1 8.4 0.0 1.3 58.4 2.0 14.6 8.2 75.0 1.3 0.3 0.0 0.2 0.6 0.0 0.8 111.4 20.3 0.3 11.9 3.9 0.0 4.0 23.2 0.0 0.0 2.7 0.0 1.0 0.1 10.2 160.8 0.0 0.0 19.8 15.6 73.9 6.9 0.2 0.0 0.2 4.1 0.0 0.0 185.3 252.2 1.8 2.8 0.1 138.8 17.4 CA13 "CAXIII, FLJ37995, MGC59868" ENSG00000185015 "Carbonic anhydrase 13" Q8N1Q1 8 85220587-85284073 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 14.6" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 33.3;Proximal enterocytes: 52.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HEL: 15.6;OE19: 30.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA024689, CAB025567" Enhanced Approved Nucleoplasm,Nucleoli,Vesicles NA NA 27000 "Cluster 46: Basophils - DNA binding" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 21: OE19 - Mitochondria" "Cluster 45: Enterocytes - Digestion" Nucleoli "Nucleoplasm, Vesicles" "CAB025567: , HPA024689: AB_1846004" "unprognostic (1.12e-2)" "unprognostic (2.20e-1)" "unprognostic (1.75e-1)" "unprognostic (9.16e-5)" "unprognostic (2.21e-2)" "unprognostic (2.08e-1)" "unprognostic (9.39e-2)" "unprognostic (7.90e-3)" "unprognostic (1.97e-1)" "unprognostic (1.34e-2)" "unprognostic (3.58e-2)" "unprognostic (3.13e-1)" "prognostic favorable (9.40e-4)" "unprognostic (7.59e-2)" "unprognostic (1.59e-1)" "unprognostic (1.55e-2)" "unprognostic (3.00e-1)" 1.8 2.1 1.2 1.2 1.2 0.3 2.3 1.4 1.3 2.1 0.7 2.5 12.0 0.9 0.6 5.0 1.1 5.4 3.6 1.0 1.7 5.7 3.7 2.4 0.6 0.9 1.5 1.1 1.1 9.0 2.9 0.3 0.8 1.2 3.0 2.3 4.8 0.7 0.4 5.6 14.6 0.8 0.6 0.7 5.9 0.7 1.1 0.7 5.0 0.3 2.9 2.1 2.5 1.3 0.2 0.4 0.8 0.1 0.5 0.6 0.4 1.0 1.1 0.1 2.9 7.2 5.4 0.4 0.5 1.2 6.0 2.3 2.2 2.9 0.2 1.6 0.9 15.6 2.0 6.7 1.4 0.2 0.6 2.2 0.5 0.2 1.2 1.8 1.6 0.6 4.0 2.9 2.6 0.0 0.3 0.2 0.4 30.6 0.4 0.2 2.2 0.1 8.1 0.3 0.2 0.0 0.5 0.0 1.6 1.0 0.5 0.8 1.5 2.8 3.9 0.1 1.6 1.1 0.6 1.9 5.7 2.2 2.6 0.7 0.6 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.1 0.1 0.0 0.2 0.2 0.0 0.2 1.2 1.2 1.4 1.3 1.0 1.7 0.9 1.5 0.8 0.6 1.1 1.3 1.7 3.2 12.4 7.2 2.9 1.8 2.7 2.7 3.4 1.8 7.0 4.7 6.4 4.3 10.5 12.9 33.3 0.3 2.1 12.3 9.8 4.0 11.3 4.7 2.5 2.7 4.8 3.2 12.2 1.6 0.3 2.9 9.7 7.7 0.0 0.3 8.6 5.8 1.1 0.0 13.7 4.3 2.0 2.5 3.3 13.1 0.0 3.0 5.4 1.9 1.0 1.9 8.2 16.1 4.4 4.4 4.3 0.0 6.9 1.9 52.6 21.0 9.5 5.1 0.0 8.1 1.9 1.3 2.1 9.1 3.1 0.3 2.2 1.0 5.4 2.4 CA14 ENSG00000118298 "Carbonic anhydrase 14" Q9ULX7 1 150257251-150265078 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 33.3;retina: 39.4;skeletal muscle: 33.7;tongue: 47.4" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 69.5;Melanocytes: 53.4;Muller glia cells: 164.5;Oligodendrocytes: 25.7" "Cancer enriched" "Detected in many" 5 "melanoma: 23.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "AF22: 102.2;AN3-CA: 65.9;NTERA-2: 83.9;SK-MEL-30: 217.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008482 Approved Approved "Plasma membrane" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 54: Non-specific - Microtubule organization" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 5: Muller glia cells - Visual perception" "Plasma membrane" "HPA008482: AB_1078395" "unprognostic (3.06e-2)" "unprognostic (1.67e-1)" "unprognostic (2.10e-2)" "unprognostic (3.25e-2)" "prognostic favorable (8.47e-4)" "unprognostic (7.28e-2)" "unprognostic (4.48e-2)" "unprognostic (1.49e-1)" "unprognostic (2.10e-1)" "unprognostic (2.47e-1)" "unprognostic (5.46e-2)" "unprognostic (1.73e-1)" "unprognostic (5.89e-3)" "unprognostic (1.91e-1)" "unprognostic (1.49e-1)" "unprognostic (1.22e-1)" "unprognostic (5.80e-2)" 0.0 0.2 8.6 0.2 14.4 1.2 0.3 15.9 27.6 0.1 33.3 3.8 0.4 0.1 0.4 1.9 1.7 0.6 7.6 8.7 11.3 0.3 8.7 0.2 0.1 14.3 14.0 1.4 0.2 3.4 0.5 0.3 14.6 4.0 0.7 39.4 0.4 20.3 33.7 5.4 1.3 0.5 12.5 0.2 1.2 0.5 13.3 0.0 1.0 47.4 0.0 0.6 0.1 20.6 0.9 0.2 102.2 65.9 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.6 0.7 0.1 0.5 0.0 0.1 0.3 0.2 0.1 0.0 0.2 1.1 0.3 0.3 6.9 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.6 0.0 0.8 0.1 0.6 0.0 0.9 0.3 0.3 83.9 0.4 1.1 0.1 0.3 0.3 0.0 0.2 3.2 1.8 0.0 0.3 217.9 14.6 0.8 0.4 0.1 0.1 0.2 0.2 0.4 0.9 4.9 0.4 0.7 0.5 0.2 0.0 0.2 0.4 0.4 0.5 0.1 0.5 0.2 0.3 0.0 0.6 0.3 0.3 0.5 0.0 0.1 0.6 0.0 0.0 8.6 14.4 15.9 27.6 8.7 11.3 14.3 14.0 14.6 12.5 13.3 20.6 0.1 3.2 0.5 0.3 0.2 2.2 0.3 0.3 0.0 1.3 0.1 0.0 69.5 0.0 0.7 0.0 0.0 0.4 0.0 0.3 0.0 0.8 0.0 0.3 0.1 0.6 0.0 0.0 0.1 0.7 0.1 3.4 0.0 0.2 0.0 0.0 0.0 6.1 0.1 0.0 0.1 0.3 0.0 0.3 0.9 0.2 0.9 0.1 53.4 0.0 0.0 164.5 0.0 0.0 25.7 1.9 0.3 3.4 0.0 0.3 0.0 0.1 0.1 4.9 0.0 0.6 0.5 0.0 0.2 0.0 0.4 0.3 0.1 0.0 0.2 0.5 CA2 "CA-II, CAII, Car2" ENSG00000104267 "Carbonic anhydrase 2" P00918 8 85463968-85481493 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Lyase "Disease variant, FDA approved drug targets, Osteopetrosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 687.4;stomach 1: 1108.7" "Cell type enhanced" "Detected in many" "Distal enterocytes: 1773.2;Erythroid cells: 2448.1;Gastric mucus-secreting cells: 1380.7;Muller glia cells: 1536.4;Paneth cells: 781.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 51.2" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HaCaT: 263.8;HEK 293: 1097.8;THP-1: 461.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001550, CAB010102" Enhanced NA Yes 570000000 "Cluster 38: Basophils - Unknown function" "Cluster 9: Intestine - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 6: Erythroid cells - Oxygen transport" "CAB010102: AB_626796, HPA001550: AB_1078393" "unprognostic (6.78e-2)" "unprognostic (3.06e-2)" "unprognostic (1.05e-2)" "unprognostic (1.63e-1)" "unprognostic (2.59e-1)" "unprognostic (9.24e-2)" "unprognostic (1.74e-1)" "unprognostic (1.72e-2)" "unprognostic (1.07e-1)" "unprognostic (5.23e-2)" "unprognostic (1.57e-1)" "unprognostic (9.89e-2)" "prognostic favorable (5.57e-6)" "unprognostic (2.45e-1)" "unprognostic (2.03e-1)" "unprognostic (1.32e-1)" "unprognostic (6.49e-3)" 7.4 10.1 95.9 36.8 127.5 246.8 37.9 122.1 143.8 5.0 444.0 687.4 285.2 2.9 10.6 19.8 2.7 112.7 15.9 105.2 107.8 331.2 273.5 43.1 6.6 115.5 112.0 0.4 55.1 10.1 6.1 19.6 114.2 1.9 643.6 390.4 74.7 68.4 42.7 81.0 31.3 32.3 98.2 8.4 1108.7 21.2 115.6 5.1 15.9 62.8 4.3 2.9 5.2 145.5 3.7 2.8 12.2 0.0 0.1 0.0 31.2 0.0 0.0 0.0 0.0 15.1 0.9 0.0 9.5 0.0 0.1 263.8 37.4 13.2 0.0 0.0 1097.8 35.8 17.0 0.5 0.0 23.7 5.1 0.0 63.9 0.0 3.7 0.0 0.0 0.0 0.3 0.2 0.0 0.4 0.4 41.4 3.7 86.5 0.0 21.2 1.3 0.5 3.7 8.8 0.2 0.3 5.0 0.0 0.1 9.6 0.0 461.5 0.0 0.0 6.6 0.0 0.4 0.4 1.0 0.1 1.8 0.1 0.0 51.2 5.3 8.6 0.2 15.0 7.4 1.3 0.1 0.8 15.4 3.0 0.0 0.0 12.6 0.1 13.4 1.4 0.0 33.3 95.9 127.5 122.1 143.8 105.2 107.8 115.5 112.0 114.2 98.2 115.6 145.5 19.4 16.0 79.9 34.0 19.6 90.6 1.3 152.5 17.6 23.1 56.9 18.4 19.8 430.4 22.4 161.8 64.6 15.2 2.4 1773.2 348.3 60.1 65.9 3.3 1.3 26.7 30.5 2448.1 1.4 11.3 403.1 6.4 1380.7 8.3 15.9 0.4 4.2 135.6 35.4 13.5 22.3 116.0 10.2 11.0 216.5 232.1 3.4 51.8 74.7 6.5 6.6 1536.4 1.0 3.0 226.4 16.1 781.9 2.2 10.3 3.5 0.3 468.2 3.9 66.1 0.0 12.1 8.2 3.1 2.8 31.2 111.7 17.1 11.7 0.7 390.8 0.5 CA3 "CAIII, Car3" ENSG00000164879 "Carbonic anhydrase 3" P07451 8 85373436-85449040 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "skeletal muscle: 5273.7" "Group enriched" "Detected in many" 8 "Erythroid cells: 221.3;Skeletal myocytes: 304.0" "Group enriched" "Detected in many" 7 "glioma: 23.1;prostate cancer: 9.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "HEL: 47.3;RH-30: 78.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "CAB004967, HPA021775, HPA026700" Enhanced NA NA 53000000 "Cluster 33: Striated muscle - Muscle contraction" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 37: Myocytes - Muscle contraction" "CAB004967: AB_437014, HPA021775: AB_1845990, HPA026700: AB_1845991" "prognostic favorable (4.24e-6)" "unprognostic (1.40e-1)" "unprognostic (1.50e-2)" "unprognostic (2.22e-3)" "unprognostic (4.71e-2)" "unprognostic (8.43e-3)" "unprognostic (3.56e-2)" "unprognostic (4.04e-2)" "unprognostic (1.11e-1)" "unprognostic (3.68e-1)" "unprognostic (4.71e-2)" "unprognostic (3.54e-1)" "unprognostic (3.19e-2)" "unprognostic (1.18e-1)" "unprognostic (9.96e-2)" "unprognostic (1.39e-1)" "unprognostic (2.19e-1)" 43.4 3.8 2.4 0.3 2.3 9.9 6.4 2.7 3.7 5.1 1.4 1.7 1.8 8.3 2.1 64.8 9.8 2.2 19.5 2.3 2.8 3.7 2.4 24.6 0.4 2.9 2.3 1.4 1.3 1.0 3.8 0.3 2.0 89.5 1.1 5.5 15.4 2.7 5273.7 5.2 4.4 19.1 2.5 0.8 4.1 2.9 2.5 1.4 3.0 1018.8 0.6 1.5 5.5 2.8 2.0 0.0 1.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.8 1.1 0.0 0.1 0.0 0.1 0.2 0.3 0.3 0.0 0.5 0.2 47.3 0.0 1.2 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 7.6 0.0 0.0 78.0 0.0 1.5 0.0 0.1 0.0 0.0 0.0 0.0 1.4 0.0 2.1 0.0 0.0 0.7 0.0 0.1 0.0 0.0 0.0 0.3 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 2.4 2.3 2.7 3.7 2.3 2.8 2.9 2.3 2.0 2.5 2.5 2.8 0.3 3.2 4.2 2.3 0.1 0.5 1.7 0.6 1.2 0.0 14.5 0.6 1.0 5.7 0.6 0.0 6.2 1.1 0.4 0.4 0.0 0.6 24.1 0.4 0.2 2.2 0.0 221.3 2.2 0.2 0.2 9.1 0.0 0.7 0.0 0.2 2.5 0.3 0.4 0.0 2.5 0.4 0.0 0.3 0.4 7.0 0.3 2.5 0.0 0.0 0.0 29.6 0.0 1.5 0.7 0.2 1.7 0.0 0.0 0.5 8.5 0.6 1.0 1.6 0.0 304.0 5.1 0.6 1.3 0.2 1.0 1.6 1.4 0.3 0.9 0.3 CA4 "CAIV, Car4, RP17" ENSG00000167434 "Carbonic anhydrase 4" P22748 17 60149942-60170899 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Lyase "Disease variant, FDA approved drug targets, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 263.6" "Group enriched" "Detected in many" 16 "Adipocytes: 704.2;Distal enterocytes: 1289.3;Paneth cells: 2368.3" "Cancer enhanced" "Detected in many" "colorectal cancer: 7.3" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 7 "neutrophil: 99.5" "Lineage enriched" "Detected in single" 995 "granulocytes: 99.5" "Cell line enhanced" "Detected in single" "OE19: 1.1" "Region enriched" "Detected in all" 5 "cerebellum: 300.3" "Low region specificity" "Detected in all" "HPA011089, HPA017258" Enhanced Uncertain Vesicles,Cytosol NA NA 190000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 37: Intestine - Unknown function" "Cluster 5: NTERA-2 - Transcription" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol Vesicles "HPA011089: AB_1845996, HPA017258: AB_1845997" "unprognostic (2.07e-2)" "unprognostic (7.85e-2)" "unprognostic (1.55e-2)" "unprognostic (7.78e-3)" "unprognostic (8.42e-2)" "unprognostic (1.19e-1)" "unprognostic (3.19e-2)" "unprognostic (5.84e-2)" "unprognostic (7.76e-2)" "unprognostic (9.74e-2)" "unprognostic (1.54e-1)" "unprognostic (1.71e-2)" "unprognostic (2.68e-3)" "unprognostic (8.59e-2)" "unprognostic (1.43e-1)" "unprognostic (2.45e-1)" "unprognostic (4.57e-2)" 83.0 2.3 17.8 3.1 18.8 19.5 80.9 86.8 34.2 12.7 13.9 263.6 3.8 6.0 51.9 1.0 5.0 38.3 55.2 22.8 13.9 47.6 0.7 87.2 0.6 13.4 17.8 6.2 31.8 16.9 15.7 8.6 22.8 8.2 172.6 0.1 10.4 36.9 30.5 3.8 11.2 2.7 12.7 16.0 10.0 1.3 15.1 1.6 74.6 42.3 0.1 6.2 5.6 14.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 1.1 0.0 0.0 0.0 0.3 0.5 0.0 0.2 0.0 0.0 0.0 0.0 0.7 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 99.5 0.0 0.0 0.0 0.0 0.1 17.8 18.8 86.8 34.2 22.8 13.9 13.4 17.8 22.8 12.7 15.1 14.9 704.2 0.0 2.4 1.3 1.5 1.5 0.3 0.0 2.2 0.0 2.3 2.5 9.1 0.0 0.6 14.7 0.0 0.0 1.2 1289.3 33.2 11.7 0.5 0.6 13.0 88.3 19.3 0.0 3.8 0.2 0.0 4.4 0.0 0.2 11.4 23.2 1.4 0.0 0.6 0.0 1.4 24.6 0.0 0.0 1.2 0.1 0.6 1.1 0.0 23.4 0.0 0.1 0.0 1.0 0.4 0.1 2368.3 0.0 1.2 0.1 14.9 72.4 0.7 0.0 6.6 5.0 23.4 0.1 0.0 0.1 1.1 0.0 2.4 0.4 41.7 0.3 CA5A "CA5, CAV, CAVA" ENSG00000174990 "Carbonic anhydrase 5A" P35218 16 87881546-87936580 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" Lyase "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 30 "liver: 24.2" "Cell type enriched" "Detected in many" 6 "Hepatocytes: 39.0" "Cancer enriched" "Detected in single" 26 "liver cancer: 2.0" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 36 "Hep G2: 25.5" "Not detected" "Not detected" "Low region specificity" "Detected in all" NA NA "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 15: Hepatocytes - Hemostasis" "unprognostic (1.91e-1)" "unprognostic (8.64e-3)" "unprognostic (3.36e-2)" "unprognostic (6.11e-2)" "unprognostic (2.49e-2)" "unprognostic (2.96e-1)" "unprognostic (8.39e-3)" "unprognostic (3.50e-3)" "unprognostic (1.42e-2)" "unprognostic (1.12e-1)" "unprognostic (6.55e-2)" "unprognostic (4.23e-2)" "unprognostic (7.99e-3)" "unprognostic (1.77e-1)" "unprognostic (5.03e-3)" "unprognostic (3.37e-2)" "unprognostic (2.76e-2)" 0.0 0.0 0.5 0.1 0.5 0.1 0.1 0.6 0.8 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.5 0.0 24.2 0.1 0.1 0.6 0.5 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.1 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 25.5 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.5 0.6 0.8 0.5 0.5 0.6 0.5 0.6 0.5 0.5 0.5 0.2 0.0 3.4 0.3 0.3 0.4 2.5 0.0 0.0 1.7 0.2 0.3 2.1 0.0 1.3 1.8 4.2 0.4 0.5 0.1 0.0 0.0 0.3 0.6 0.4 5.4 0.0 2.7 0.8 0.0 0.3 1.0 0.0 0.8 6.3 0.2 1.1 39.0 0.1 3.3 0.6 0.2 0.0 1.4 1.6 0.8 0.3 1.5 0.0 2.8 0.2 0.8 2.1 0.0 0.5 0.0 0.0 1.2 0.1 1.9 0.2 0.3 1.5 3.8 0.0 4.1 1.1 0.4 0.4 0.0 0.3 0.3 1.2 1.7 0.1 1.8 CA5B ENSG00000169239 "Carbonic anhydrase 5B" Q9Y2D0 X 15688830-15788411 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "dendritic cells: 37.9;Muller glia cells: 35.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC TERT1: 22.3;fHDF/TERT166: 27.0;hTERT-HME1: 34.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA012618 Uncertain Supported Mitochondria NA NA "Cluster 20: T-cells - T-cell receptor" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 30: Epithelial cell lines - Translation" "Cluster 24: Non-specific - Transcription regulation" Mitochondria "HPA012618: AB_1846000" "unprognostic (1.62e-2)" "unprognostic (2.10e-3)" "unprognostic (2.86e-1)" "unprognostic (1.55e-3)" "unprognostic (1.16e-2)" "unprognostic (4.59e-5)" "unprognostic (2.50e-1)" "unprognostic (6.89e-4)" "unprognostic (4.11e-1)" "unprognostic (3.89e-3)" "unprognostic (1.54e-1)" "unprognostic (1.17e-1)" "prognostic favorable (6.66e-6)" "unprognostic (2.43e-1)" "unprognostic (1.38e-1)" "unprognostic (8.94e-2)" "unprognostic (3.08e-1)" 5.9 3.1 5.3 4.2 5.8 3.5 8.3 3.9 5.4 21.5 5.8 2.8 1.6 7.3 2.6 6.5 7.5 7.3 4.0 3.9 7.3 4.8 2.1 6.0 5.6 8.4 6.5 11.9 3.4 9.1 2.4 3.1 6.9 4.8 3.6 10.5 4.5 4.6 1.6 5.7 2.6 7.6 6.3 4.3 4.4 10.3 6.1 4.3 7.2 5.4 6.8 5.2 5.5 4.6 4.3 2.6 2.9 4.8 8.5 22.3 1.7 4.4 5.6 3.2 4.6 1.3 2.8 1.2 4.5 27.0 6.1 4.6 10.3 5.0 5.7 1.2 4.8 2.3 3.3 1.1 8.3 3.0 5.0 5.3 5.3 4.3 34.2 5.7 4.8 3.5 1.2 3.0 15.4 2.3 2.5 2.3 1.2 0.8 18.6 1.4 2.1 2.2 4.9 3.1 2.6 5.3 6.1 2.2 3.8 3.4 3.1 3.0 6.5 3.8 2.5 20.4 2.5 2.2 2.4 1.4 4.2 6.0 7.2 4.4 3.9 0.4 16.7 4.8 14.5 4.6 16.6 15.5 4.7 5.0 12.1 10.4 2.2 11.0 3.1 0.7 14.3 10.0 5.3 5.8 3.9 5.4 3.9 7.3 8.4 6.5 6.9 6.3 6.1 4.6 9.6 0.0 7.9 14.0 19.1 4.2 6.3 3.4 6.2 9.5 7.3 5.2 2.4 0.0 7.1 1.8 16.7 1.8 37.9 1.6 1.9 4.4 1.1 9.6 7.1 13.9 3.0 11.2 11.5 4.0 1.8 10.5 11.7 6.2 2.5 6.7 6.1 2.7 1.9 1.7 11.8 2.2 8.2 9.3 11.1 1.8 7.8 10.8 3.6 19.7 9.1 35.9 32.0 8.5 10.6 4.1 1.6 5.3 18.7 11.5 1.2 2.9 12.2 7.8 6.6 8.1 8.3 4.2 5.6 5.5 4.5 1.9 30.0 12.1 1.5 7.9 CA6 ENSG00000131686 "Carbonic anhydrase 6" P23280 1 8945867-8975092 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted secreted proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 295 "salivary gland: 9393.1" "Group enriched" "Detected in some" 44 "Breast glandular cells: 77.9;Ionocytes: 99.7;Melanocytes: 179.7" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in single" "Group enriched" "Detected in some" 4 "naive CD4 T-cell: 5.6;naive CD8 T-cell: 16.4" "Lineage enriched" "Detected in many" 11 "T-cells: 16.4" "Cell line enhanced" "Detected in some" "Daudi: 1.7;U-2197: 1.3" "Not detected" "Not detected" "Low region specificity" "Detected in some" "HPA028550, HPA028692" Enhanced "Secreted to digestive system" NA NA 24000000 "Cluster 32: T-cells - Unknown function" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 30: Mammary glandular cells - Lactation" "HPA028550: AB_10600105, HPA028692: AB_10601883" "unprognostic (2.54e-5)" "unprognostic (1.09e-1)" "unprognostic (1.10e-1)" "unprognostic (2.37e-1)" "unprognostic (2.90e-1)" "unprognostic (9.28e-2)" "unprognostic (2.70e-3)" "unprognostic (1.24e-1)" "unprognostic (1.73e-1)" "unprognostic (5.93e-2)" "unprognostic (4.41e-2)" "unprognostic (4.29e-5)" "unprognostic (1.14e-1)" "unprognostic (1.31e-1)" "unprognostic (2.35e-1)" 0.4 0.4 0.3 0.7 0.6 2.0 20.8 0.9 0.7 0.0 0.5 0.1 0.3 0.2 2.3 0.2 0.1 0.2 1.5 0.4 0.3 0.1 0.1 0.3 1.3 0.9 0.4 1.9 6.3 0.0 0.1 0.9 0.7 0.2 0.2 0.7 9393.1 0.0 0.4 31.8 0.5 0.0 0.1 1.2 0.4 0.3 0.7 1.2 0.3 0.0 1.0 0.1 0.0 1.8 0.2 0.0 0.2 0.4 0.1 0.0 0.3 0.1 0.0 0.0 0.2 0.3 0.4 1.7 0.1 0.1 0.4 0.3 0.1 0.0 0.2 0.2 0.2 0.2 0.6 0.2 0.0 0.5 0.5 0.0 0.1 0.2 0.0 0.2 0.2 0.3 0.2 0.4 0.0 0.2 0.2 0.4 0.3 0.2 0.1 0.3 0.1 0.0 0.0 0.3 0.2 0.1 0.0 0.2 0.1 0.1 0.4 0.2 0.1 0.6 0.3 1.3 0.2 0.4 0.1 0.4 0.1 0.4 0.4 1.4 0.3 0.2 0.3 0.2 0.3 0.3 0.7 2.7 0.0 0.5 5.6 16.4 1.3 0.4 0.2 0.3 0.3 1.6 0.3 0.6 0.9 0.7 0.4 0.3 0.9 0.4 0.7 0.1 0.7 1.8 0.2 0.0 0.0 0.0 0.1 0.1 0.1 1.4 0.0 0.0 77.9 2.7 0.3 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 99.7 0.0 1.3 0.2 0.0 0.2 179.7 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.1 0.0 0.1 0.0 0.6 0.5 0.0 0.0 CA7 ENSG00000168748 "Carbonic anhydrase 7" P43166 16 66844414-66854153 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "intestine: 57.0" "Cell type enriched" "Detected in some" 40 "Paneth cells: 3026.3" "Cancer enhanced" "Detected in some" "colorectal cancer: 0.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "REH: 1.1;THP-1: 1.9" "Region enhanced" "Detected in all" "cerebellum: 67.2" "Low region specificity" "Detected in many" HPA047237 Uncertain NA NA "Cluster 37: Intestine - Unknown function" "Cluster 43: THP-1 - Innate immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA047237: AB_2679994" "unprognostic (8.77e-4)" "unprognostic (5.23e-4)" "unprognostic (1.57e-1)" "unprognostic (1.96e-2)" "unprognostic (2.19e-1)" "unprognostic (2.16e-2)" "unprognostic (7.90e-2)" "unprognostic (1.59e-1)" "unprognostic (1.84e-2)" "unprognostic (9.62e-2)" "unprognostic (1.69e-2)" "unprognostic (7.12e-3)" "unprognostic (8.47e-2)" "unprognostic (5.20e-1)" "unprognostic (1.90e-2)" "unprognostic (6.46e-2)" 0.0 0.0 5.1 0.2 6.7 0.0 0.1 4.8 10.7 0.0 2.1 57.0 6.9 0.1 0.9 0.1 0.0 0.0 0.0 8.0 3.1 0.0 0.0 0.0 0.0 3.8 3.5 0.0 0.0 0.0 0.1 0.0 3.5 0.0 48.6 0.0 0.0 0.2 0.0 0.0 10.0 1.1 2.6 0.0 0.0 0.5 4.7 0.1 0.0 0.2 0.0 0.0 0.0 5.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.3 1.1 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.1 6.7 4.8 10.7 8.0 3.1 3.8 3.5 3.5 2.6 4.7 5.6 0.0 0.0 0.0 0.7 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 74.2 0.0 0.0 0.0 0.0 0.0 0.0 16.3 0.0 9.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 4.1 16.9 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 3026.3 0.0 0.0 0.5 23.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.3 0.0 39.9 0.1 CA9 "CAIX, MN" ENSG00000107159 "Carbonic anhydrase 9" Q16790 9 35673918-35681159 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 12 "stomach 1: 289.3" "Cell type enhanced" "Detected in some" "Basal respiratory cells: 275.3;Cholangiocytes: 62.9;Early spermatids: 205.8;Gastric mucus-secreting cells: 259.5" "Cancer enhanced" "Detected in many" "renal cancer: 85.9" "Region enriched" "Detected in single" 9 "cerebellum: 5.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 10 "A-431: 189.3;HDLM-2: 98.1;hTERT-RPE1: 113.1;U-87 MG: 374.4" "Region enhanced" "Detected in many" "cerebellum: 12.3" "Low region specificity" "Detected in all" "CAB005100, CAB017107, HPA055207" Enhanced Supported "Plasma membrane" "Intracellular and membrane" NA NA "Cluster 4: Stomach - Digestion" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Plasma membrane" "CAB005100: AB_2066539, CAB017107: , HPA055207: AB_2682738" "unprognostic (8.01e-3)" "unprognostic (1.34e-2)" "unprognostic (2.28e-1)" "unprognostic (2.00e-2)" "unprognostic (1.59e-2)" "unprognostic (1.15e-1)" "prognostic unfavorable (1.71e-5)" "unprognostic (1.47e-2)" "unprognostic (3.90e-2)" "unprognostic (1.29e-1)" "unprognostic (6.24e-3)" "unprognostic (1.13e-1)" "prognostic unfavorable (2.22e-7)" "unprognostic (7.29e-2)" "prognostic favorable (9.50e-4)" "unprognostic (2.97e-3)" "unprognostic (8.67e-2)" 3.8 0.4 0.0 0.2 0.0 0.0 0.1 5.6 0.6 0.5 0.0 0.6 14.5 0.2 0.1 0.8 0.4 24.4 2.0 0.2 0.1 0.2 1.3 0.2 0.0 0.0 0.1 0.7 6.6 0.0 0.5 0.0 0.2 0.5 0.0 1.0 0.1 0.1 0.1 8.2 13.6 0.1 0.0 0.0 289.3 5.5 0.5 0.0 0.0 0.0 0.0 0.7 0.7 0.0 189.3 0.3 0.0 0.0 0.0 0.0 0.0 0.2 3.6 0.3 2.5 0.0 0.1 0.0 0.1 0.0 0.5 5.7 0.0 0.9 1.5 98.1 0.0 0.0 0.7 0.4 0.0 0.0 0.2 0.4 0.0 0.0 0.3 113.1 0.1 0.0 0.0 0.3 0.1 0.0 0.0 0.1 0.3 0.2 0.5 0.0 0.0 10.6 0.0 0.6 1.6 0.0 0.0 0.1 0.7 0.0 0.0 0.2 0.0 18.9 0.4 0.0 4.7 0.0 0.4 0.1 374.4 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 5.6 0.6 0.2 0.1 0.0 0.1 0.2 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.2 4.5 0.7 275.3 0.0 0.4 0.1 0.0 0.4 62.9 28.1 0.0 0.0 0.0 0.0 0.1 0.0 49.1 205.8 0.0 0.1 0.2 0.0 0.0 0.1 50.9 0.6 1.2 259.5 0.2 0.0 0.4 0.7 0.0 0.1 0.0 0.6 4.0 18.3 0.0 0.0 19.6 1.5 0.1 0.0 0.0 0.6 1.3 0.0 0.0 0.0 26.6 0.0 0.7 0.3 0.8 0.7 0.1 5.5 0.0 0.0 0.0 1.5 0.9 4.0 0.0 3.1 0.3 0.1 0.7 5.3 0.4 CBS HIP4 ENSG00000160200 "Cystathionine beta-synthase" P35520 21 43053191-43076943 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Amino-acid biosynthesis, Cysteine biosynthesis" "Allosteric enzyme, Lyase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 174.9;pancreas: 99.0" "Cell type enhanced" "Detected in some" "Basal respiratory cells: 2.3;Cardiomyocytes: 4.9;Hepatocytes: 3.6;Ionocytes: 2.0;Melanocytes: 5.4" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 51 "neutrophil: 5.0" "Lineage enriched" "Detected in single" 51 "granulocytes: 5.0" "Cell line enhanced" "Detected in many" "BEWO: 177.5;HAP1: 172.8;HHSteC: 224.1;MCF7: 197.7;RPMI-8226: 197.4" "Low region specificity" "Detected in all" HPA001223 Supported Approved Nucleoli,Vesicles NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 22: Non-specific - Unknown function" "Cluster 28: BEWO - Transcription regulation" "Cluster 48: Smooth muscle cells - ECM organization" Vesicles Nucleoli "HPA001223: AB_1846112" "unprognostic (4.86e-2)" "unprognostic (1.48e-2)" "unprognostic (6.81e-2)" "unprognostic (1.12e-3)" "unprognostic (1.32e-1)" "unprognostic (1.12e-1)" "unprognostic (9.68e-4)" "unprognostic (3.62e-1)" "unprognostic (6.76e-3)" "unprognostic (1.06e-1)" "unprognostic (6.50e-2)" "unprognostic (2.13e-1)" "unprognostic (1.61e-2)" "unprognostic (6.73e-3)" "unprognostic (2.62e-1)" "unprognostic (1.92e-2)" "unprognostic (1.02e-1)" 6.6 2.8 42.5 1.0 39.5 0.2 3.4 58.5 55.3 12.3 29.3 4.8 3.0 4.5 0.0 2.0 5.8 1.2 7.7 41.4 40.3 3.8 174.9 10.2 2.7 42.5 44.6 30.3 99.0 2.5 8.8 1.2 42.7 12.7 0.9 2.5 19.9 1.1 1.1 2.3 7.0 2.3 38.4 1.7 16.5 2.0 48.1 0.7 17.4 1.2 1.4 11.6 6.2 45.4 30.0 17.0 31.3 113.4 48.9 31.5 177.5 39.5 10.0 15.6 15.4 53.7 1.5 0.1 19.2 67.2 0.3 1.5 172.8 13.2 3.1 0.0 20.5 12.3 73.1 63.8 224.1 7.9 19.1 21.7 1.4 16.0 16.4 13.2 38.6 85.6 138.7 118.1 11.1 197.7 16.1 0.1 20.3 65.7 29.4 0.0 0.2 197.4 0.5 15.5 57.8 85.1 78.5 5.4 44.4 18.4 27.0 91.2 5.4 0.8 42.5 0.3 4.8 34.8 30.2 41.2 19.0 11.0 53.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 0.0 42.5 39.5 58.5 55.3 41.4 40.3 42.5 44.6 42.7 38.4 48.1 45.4 0.2 0.0 0.5 0.7 0.0 0.4 0.0 2.3 0.0 0.2 0.5 0.1 4.9 0.0 0.6 0.0 0.0 0.1 0.0 0.1 0.0 0.2 0.0 0.0 0.4 0.2 0.0 0.0 0.1 0.2 0.8 1.2 0.0 0.1 0.0 0.1 0.0 3.6 0.2 0.0 0.0 0.0 2.0 0.0 1.4 0.0 0.9 0.2 5.4 0.0 0.0 0.5 0.0 0.0 0.0 0.4 1.3 0.0 0.0 0.2 1.7 0.1 0.1 0.1 0.0 0.3 0.6 0.0 0.6 0.0 1.0 0.1 0.1 0.0 0.2 0.1 CBSL ENSG00000274276 "Cystathionine beta-synthase like" P0DN79 21 6444869-6468040 "Enzymes, Predicted intracellular proteins" "Amino-acid biosynthesis, Cysteine biosynthesis" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "liver: 88.1;pancreas: 48.5" "Not detected" "Not detected" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 14 "neutrophil: 1.3" "Lineage enriched" "Detected in single" 14 "granulocytes: 1.3" "Cell line enhanced" "Detected in many" "AN3-CA: 105.1;NTERA-2: 246.2;U-266/70: 75.7" HPA001223 Supported Approved Nucleoli,Vesicles NA NA 510000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 85: Liver - Metabolism" "Cluster 5: NTERA-2 - Transcription" "Cluster 16: Pancreatic endocrine cells - Mixed function" Vesicles Nucleoli "HPA001223: AB_1846112" "unprognostic (2.39e-1)" "unprognostic (1.54e-2)" "unprognostic (1.15e-1)" "unprognostic (4.78e-3)" "unprognostic (6.49e-2)" "unprognostic (1.42e-2)" "unprognostic (1.28e-2)" "unprognostic (6.62e-3)" "unprognostic (1.17e-1)" "unprognostic (3.62e-2)" "unprognostic (7.50e-2)" "unprognostic (1.10e-1)" "unprognostic (2.04e-1)" "unprognostic (3.17e-3)" "unprognostic (8.44e-2)" "unprognostic (2.46e-1)" "unprognostic (3.61e-1)" 3.8 1.2 0.9 0.8 0.8 0.1 1.7 1.6 1.3 7.5 0.3 2.3 2.0 1.8 1.4 1.0 5.6 1.0 4.4 0.6 0.9 1.6 88.1 4.8 0.1 1.3 1.6 14.7 48.5 2.2 4.4 0.8 1.1 6.1 0.0 1.1 4.6 8.9 0.6 1.2 3.7 0.0 0.6 1.2 8.2 1.0 1.6 0.2 12.3 0.0 0.4 5.0 3.1 1.3 0.1 0.0 36.3 105.1 0.0 0.0 1.4 23.3 15.2 8.9 29.3 0.2 18.2 0.0 0.1 0.0 17.1 12.1 0.2 13.5 5.6 0.0 35.4 0.0 0.0 0.0 1.0 0.0 16.1 12.8 51.5 0.1 23.1 0.0 0.2 0.8 0.7 41.5 0.3 0.0 18.9 2.6 246.2 0.5 0.0 0.3 0.0 0.3 40.5 0.0 38.7 58.5 0.0 3.4 44.9 0.0 0.1 0.1 0.0 2.7 0.0 17.3 4.4 75.7 29.6 0.3 10.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.9 0.8 1.6 1.3 0.6 0.9 1.3 1.6 1.1 0.6 1.6 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CHAC1 MGC4504 ENSG00000128965 "ChaC glutathione specific gamma-glutamylcyclotransferase 1" Q9BUX1 15 40952962-40956512 "Enzymes, Predicted intracellular proteins" "Apoptosis, Neurogenesis, Notch signaling pathway, Unfolded protein response" Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pancreas: 68.6;skeletal muscle: 68.4" "Cell type enhanced" "Detected in many" "Distal tubular cells: 35.2;Exocrine glandular cells: 27.8;Gastric mucus-secreting cells: 33.6;Pancreatic endocrine cells: 19.3;Plasma cells: 21.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ hTERT+: 109.5;HHSteC: 80.7;hTCEpi: 130.8;SK-MEL-30: 95.0;U-266/70: 81.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA042708, HPA043505" Approved Approved Mitochondria NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 80: Striated muscle - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 1: Pancreatic cells - Digestion" Mitochondria "HPA042708: AB_2678125, HPA043505: AB_2678518" "unprognostic (6.04e-3)" "unprognostic (2.81e-2)" "unprognostic (7.47e-2)" "unprognostic (2.84e-3)" "unprognostic (6.57e-3)" "unprognostic (2.00e-2)" "unprognostic (5.59e-2)" "unprognostic (2.43e-1)" "unprognostic (2.01e-1)" "unprognostic (1.72e-1)" "unprognostic (3.11e-1)" "unprognostic (1.51e-1)" "prognostic unfavorable (2.23e-7)" "unprognostic (1.37e-2)" "unprognostic (1.44e-1)" "unprognostic (1.67e-2)" "unprognostic (3.91e-2)" 9.1 0.6 12.3 1.4 12.0 1.8 0.9 11.1 30.7 2.1 7.1 1.9 2.0 0.7 1.5 23.3 1.7 1.8 2.4 11.4 16.6 4.0 11.5 2.0 0.9 13.0 14.5 0.7 68.6 1.4 1.9 0.8 16.9 1.3 0.8 1.1 5.1 1.0 68.4 1.6 1.4 0.8 12.6 0.9 14.8 0.7 17.6 0.5 1.5 11.7 3.0 4.3 3.7 16.6 9.1 6.0 1.5 27.2 4.3 3.2 11.1 53.5 109.5 5.8 15.5 15.1 2.2 2.8 4.1 4.8 17.2 6.0 12.0 4.4 4.1 10.4 2.5 2.5 1.6 0.0 80.7 7.3 0.1 36.1 130.8 17.1 23.2 1.8 5.4 62.3 7.7 12.5 4.8 5.5 5.3 0.1 4.9 31.0 21.3 4.8 0.1 12.8 3.0 3.5 5.3 7.9 1.6 9.5 95.0 3.3 3.6 51.1 1.8 1.3 16.1 1.5 9.4 81.1 19.0 11.0 4.8 10.3 12.7 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 12.3 12.0 11.1 30.7 11.4 16.6 13.0 14.5 16.9 12.6 17.6 16.6 6.2 0.0 2.0 0.3 3.1 2.8 3.8 11.5 3.4 2.6 2.2 2.4 4.6 4.3 6.5 0.0 2.1 0.3 2.6 8.0 35.2 6.4 0.1 1.8 0.4 2.7 3.5 3.2 1.3 27.8 0.3 0.6 33.6 2.1 0.0 0.4 1.8 0.7 0.4 0.0 1.5 8.0 6.1 0.3 1.5 0.0 0.3 0.8 5.4 0.0 1.0 0.5 0.0 0.5 0.2 19.3 2.3 0.0 21.4 6.5 0.8 0.3 3.3 0.4 0.0 0.3 3.2 1.1 1.1 1.5 4.3 3.4 1.6 0.5 4.8 14.6 CHAC2 GCG1 ENSG00000143942 "ChaC glutathione specific gamma-glutamylcyclotransferase 2" Q8WUX2 2 53767804-53775196 "Enzymes, Predicted intracellular proteins" Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Erythroid cells: 44.0;Plasma cells: 27.0;Spermatocytes: 47.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049235 Approved Approved Cytosol NA NA "Cluster 24: B-cells - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 44: HDLM-2 - Immune response" "Cluster 12: Non-specific - Cell cycle regulation" Cytosol "HPA049235: AB_2680686" "unprognostic (2.22e-1)" "unprognostic (1.31e-1)" "unprognostic (2.11e-2)" "unprognostic (3.91e-3)" "unprognostic (1.61e-2)" "unprognostic (4.74e-3)" "prognostic unfavorable (3.80e-7)" "unprognostic (5.52e-2)" "unprognostic (1.74e-2)" "unprognostic (1.30e-2)" "unprognostic (1.36e-2)" "unprognostic (3.09e-2)" "unprognostic (4.28e-6)" "unprognostic (1.52e-1)" "unprognostic (1.79e-1)" "unprognostic (1.22e-1)" "unprognostic (2.55e-1)" 5.0 4.4 1.6 4.8 1.7 6.9 2.1 2.4 2.4 1.2 0.9 4.4 7.3 1.1 2.6 4.5 0.7 1.3 2.5 1.6 2.0 2.9 4.4 1.4 6.6 1.6 1.6 0.6 1.9 1.3 1.6 1.1 1.5 1.7 3.7 3.7 1.7 1.5 4.9 1.2 4.5 2.2 1.3 4.2 4.5 5.4 1.8 4.9 1.0 4.7 6.5 3.2 2.2 1.4 39.9 13.0 13.5 12.1 6.7 3.3 2.9 17.9 3.6 12.5 14.8 9.1 10.0 33.5 25.3 7.8 18.8 14.0 31.1 21.3 21.7 71.3 27.1 26.6 16.3 15.0 10.2 31.8 11.6 4.2 6.2 23.2 17.5 3.3 24.8 23.0 27.8 19.2 16.6 13.0 38.0 26.5 17.5 17.1 23.1 28.6 28.9 34.2 17.3 10.6 16.8 4.7 20.7 15.3 8.7 8.1 9.3 12.5 11.0 7.3 26.1 28.2 29.3 18.9 26.1 28.8 9.9 39.5 10.2 1.3 0.3 0.8 3.5 0.7 3.7 4.3 3.8 3.9 0.8 4.4 4.3 4.1 1.0 1.1 0.5 1.8 3.9 1.9 1.6 1.7 2.4 2.4 1.6 2.0 1.6 1.6 1.5 1.3 1.8 1.4 2.3 0.0 1.1 2.0 11.7 3.4 3.7 7.4 0.6 1.6 2.2 2.0 3.0 7.2 4.1 1.8 0.0 1.9 5.1 3.4 11.7 5.4 13.1 2.2 1.0 3.0 0.0 44.0 4.8 8.0 0.9 1.6 10.2 2.2 1.3 1.5 3.3 7.6 7.8 1.7 4.3 4.6 2.0 1.9 3.0 3.5 2.8 1.7 3.6 1.0 5.8 5.7 8.2 5.0 2.1 7.9 1.4 4.1 27.0 4.1 3.7 9.8 1.9 6.8 0.0 2.4 3.1 47.0 6.6 5.5 3.4 0.4 5.3 5.1 10.6 4.0 CLYBL CLB ENSG00000125246 "Citramalyl-CoA lyase" Q8N0X4 13 99606669-99897134 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Lyase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 109.7" "Cell type enhanced" "Detected in many" "Astrocytes: 84.9;Distal tubular cells: 138.9;Hepatocytes: 84.1;Proximal tubular cells: 144.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "OE19: 56.1;SCLC-21H: 53.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039959, HPA040691" Enhanced NA NA 7300 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 8: Non-specific - Mitochondria" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA039959: AB_10793857, HPA040691: AB_10794746" "unprognostic (1.25e-2)" "unprognostic (1.94e-1)" "unprognostic (2.30e-3)" "unprognostic (7.57e-3)" "unprognostic (3.69e-1)" "unprognostic (2.90e-2)" "unprognostic (1.57e-3)" "unprognostic (2.91e-1)" "unprognostic (2.10e-1)" "unprognostic (2.34e-1)" "unprognostic (2.49e-2)" "unprognostic (2.85e-1)" "prognostic favorable (6.66e-16)" "unprognostic (3.74e-2)" "unprognostic (5.41e-2)" "unprognostic (4.78e-2)" "unprognostic (7.82e-2)" 7.1 16.2 11.4 5.5 11.8 5.1 10.5 24.4 12.7 7.7 35.3 20.6 25.0 6.5 13.0 11.3 7.9 6.9 22.6 12.6 8.6 66.0 109.7 5.6 10.4 9.1 9.0 5.7 9.8 14.4 6.7 3.7 7.3 6.9 21.9 7.3 12.3 8.9 43.3 9.3 23.5 6.4 5.6 8.6 8.7 9.3 10.7 5.8 12.3 69.5 10.8 7.4 6.9 8.8 0.4 2.3 16.6 7.5 7.6 7.0 3.6 0.8 1.6 1.4 2.6 0.3 12.4 3.0 4.8 1.0 3.2 3.9 1.5 2.8 1.8 15.3 2.4 19.2 4.9 11.8 5.2 10.4 1.3 3.8 8.3 0.2 6.4 1.6 2.2 15.7 2.7 9.8 1.6 4.3 4.7 14.3 10.8 56.1 3.4 6.0 0.7 7.1 16.6 1.1 53.1 8.1 3.4 3.8 3.6 5.9 8.0 13.2 0.3 0.7 1.9 1.4 2.7 22.3 4.7 0.6 11.3 14.9 2.3 1.7 4.5 0.5 9.9 10.0 12.0 14.5 17.4 13.9 9.4 15.7 13.3 15.8 0.6 14.2 4.8 10.3 24.2 7.7 11.4 11.8 24.4 12.7 12.6 8.6 9.1 9.0 7.3 5.6 10.7 8.8 7.4 6.4 5.0 84.9 8.6 5.5 9.1 18.4 8.6 2.3 8.9 11.3 36.1 21.5 10.9 14.7 2.1 14.3 9.2 17.9 138.9 11.6 1.6 6.1 4.1 6.2 1.2 2.5 30.6 8.1 3.2 5.9 5.6 4.4 6.3 7.1 4.6 84.1 7.6 0.0 25.6 11.5 10.2 6.7 4.5 4.8 2.1 5.4 16.0 48.7 4.4 6.5 7.2 21.6 9.5 4.0 13.8 4.1 3.8 4.3 23.1 144.7 4.1 5.0 0.0 7.6 18.1 3.0 10.5 6.9 6.3 7.4 8.3 13.6 19.1 6.7 CSAD "CSD, PCAP" ENSG00000139631 "Cysteine sulfinic acid decarboxylase" Q9Y600 12 53157663-53180925 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Decarboxylase, Lyase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 4 "neutrophil: 16.3" "Lineage enriched" "Detected in all" 5 "granulocytes: 16.3" "Cell line enhanced" "Detected in all" "ASC diff: 84.5;T-47d: 52.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039487 Approved "Intracellular and membrane" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 85: Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 52: Non-specific - Transcription" "HPA039487: AB_10672776" "unprognostic (1.00e-1)" "unprognostic (3.28e-2)" "prognostic unfavorable (9.50e-4)" "unprognostic (1.57e-1)" "unprognostic (7.99e-2)" "prognostic favorable (6.33e-4)" "prognostic favorable (1.37e-4)" "unprognostic (2.46e-2)" "unprognostic (7.87e-3)" "unprognostic (1.01e-1)" "prognostic favorable (3.39e-4)" "unprognostic (3.48e-2)" "prognostic unfavorable (1.93e-6)" "unprognostic (4.59e-2)" "unprognostic (3.47e-1)" "unprognostic (1.38e-1)" "prognostic favorable (6.81e-6)" 68.0 28.3 24.3 15.9 25.4 39.1 62.4 25.2 25.7 54.9 33.8 34.3 17.3 31.2 52.3 29.3 41.5 19.2 25.2 24.0 24.5 39.2 101.7 30.8 19.1 26.1 23.0 54.0 35.9 14.9 40.9 13.0 24.8 50.3 16.0 16.8 34.7 19.8 19.6 59.6 28.5 19.6 20.2 37.5 31.9 27.7 24.7 14.2 36.0 7.7 14.1 25.8 37.6 36.7 3.7 6.8 16.0 6.8 84.5 34.4 5.7 14.5 3.2 6.0 5.0 4.1 8.8 4.9 10.6 7.7 2.0 12.6 7.1 11.2 3.5 6.6 8.6 7.8 19.4 8.8 7.6 3.3 4.9 42.6 13.8 9.0 11.2 30.8 5.6 10.4 8.4 42.8 5.7 30.8 1.8 9.2 3.1 1.9 6.3 6.6 1.0 11.4 8.0 9.6 8.0 6.3 14.3 19.9 5.7 9.9 52.7 6.5 12.6 17.5 3.4 5.2 4.2 12.2 3.4 2.6 14.7 8.3 7.1 3.7 2.0 2.5 1.3 1.1 0.8 1.1 1.8 0.8 1.0 1.8 2.4 1.4 16.3 1.6 1.3 2.3 3.4 0.5 24.3 25.4 25.2 25.7 24.0 24.5 26.1 23.0 24.8 20.2 24.7 36.7 23.5 3.2 22.0 40.1 15.6 16.6 28.3 18.3 4.0 29.0 27.9 43.4 8.9 20.0 17.4 23.9 16.7 12.2 18.5 19.3 3.9 12.6 0.7 11.6 20.4 22.5 14.4 0.4 47.0 9.1 6.9 23.0 19.4 14.3 9.5 22.0 21.4 38.2 8.4 26.9 51.1 21.3 14.2 11.9 12.8 3.5 27.1 11.1 14.2 30.0 15.6 18.3 20.6 34.2 62.4 10.0 25.5 30.9 6.9 28.8 22.5 5.1 15.4 30.0 39.5 22.5 27.9 48.0 64.4 5.5 18.3 8.9 13.0 17.9 15.4 24.2 CTH ENSG00000116761 "Cystathionine gamma-lyase" P32929 1 70411218-70439851 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Amino-acid biosynthesis, Cysteine biosynthesis" "Calmodulin-binding, Lyase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 5 "liver: 122.9;ovary: 34.4" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 38.0;Hepatocytes: 141.6" "Group enriched" "Detected in all" 5 "liver cancer: 30.0;testis cancer: 8.1" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HHSteC: 39.7;Karpas-707: 63.8;SK-MEL-30: 85.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021591, HPA023300" Enhanced NA NA 220000 "Cluster 19: B-cells - Humoral immune response" "Cluster 62: Liver - Hemostasis" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 2: Hepatocytes - Metabolism" "HPA021591: AB_1847321, HPA023300: AB_1847322" "unprognostic (3.41e-2)" "unprognostic (1.36e-1)" "unprognostic (1.48e-1)" "unprognostic (2.76e-1)" "unprognostic (7.66e-2)" "unprognostic (2.45e-3)" "prognostic favorable (8.69e-4)" "unprognostic (1.71e-1)" "unprognostic (1.95e-1)" "unprognostic (1.00e-1)" "unprognostic (1.43e-3)" "unprognostic (5.05e-3)" "unprognostic (3.25e-2)" "unprognostic (1.03e-1)" "unprognostic (8.97e-2)" "unprognostic (3.05e-3)" "unprognostic (1.26e-1)" 4.3 12.9 3.4 1.3 3.1 3.4 2.9 3.3 4.0 2.5 4.5 5.1 5.2 2.2 1.6 4.5 3.8 1.8 2.4 3.3 3.6 13.5 122.9 3.1 0.9 3.4 3.7 34.4 17.0 1.4 2.9 1.1 3.4 4.3 6.2 8.1 2.5 2.1 3.6 1.2 5.3 1.3 2.7 1.0 7.4 4.1 3.7 0.6 7.7 2.9 1.3 2.2 1.9 3.2 10.2 1.5 7.1 10.0 8.5 4.8 15.0 4.3 4.1 3.8 15.7 3.2 6.4 5.8 3.4 3.1 9.3 4.9 27.3 3.1 7.2 17.3 5.9 7.0 5.1 9.4 39.7 7.8 1.7 7.5 24.4 7.5 8.8 1.5 3.2 11.9 14.0 63.8 2.2 3.2 2.7 1.9 7.2 4.2 5.9 3.0 3.7 16.2 7.3 0.1 3.9 3.3 6.6 7.7 85.7 13.3 2.6 4.6 1.1 1.2 7.7 5.7 4.1 23.8 15.3 3.1 9.8 16.1 3.1 0.8 0.3 0.1 1.2 0.2 2.1 2.2 1.1 1.7 0.5 1.7 3.2 1.5 0.4 0.2 0.2 0.7 0.3 0.6 3.4 3.1 3.3 4.0 3.3 3.6 3.4 3.7 3.4 2.7 3.7 3.2 2.8 6.4 5.6 16.6 6.7 2.5 8.0 2.2 6.2 9.4 6.2 5.8 1.9 5.7 2.5 5.5 10.4 0.8 5.5 16.1 11.7 1.8 27.2 38.0 6.4 3.3 3.0 7.4 7.8 4.2 1.8 13.6 14.8 19.7 0.0 1.9 3.9 141.6 1.2 0.0 7.4 7.9 2.0 3.5 5.7 5.2 1.2 4.7 19.6 1.9 0.0 4.4 0.0 7.1 4.2 6.4 12.9 4.1 10.8 4.0 11.1 29.2 0.7 11.6 0.0 2.8 17.7 1.4 0.6 4.8 2.0 0.8 11.2 4.5 9.1 3.8 CYP1A1 "CP11, CYP1, P1-450, P450-C, P450DX" ENSG00000140465 "Cytochrome P450 family 1 subfamily A member 1" P04798 15 74719542-74725536 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis" "Lyase, Monooxygenase, Oxidoreductase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 66.1;urinary bladder: 63.6" "Cell type enhanced" "Detected in some" "Adipocytes: 21.9;Endothelial cells: 13.7;Glandular and luminal cells: 5.9;Hepatocytes: 9.9;Urothelial cells: 16.4" "Group enriched" "Detected in some" 24 "liver cancer: 18.6;urothelial cancer: 54.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CACO-2: 36.9;hTCEpi: 19.5;HUVEC TERT2: 19.1;SK-BR-3: 14.7;SuSa: 35.6" "Not detected" "Not detected" "Not detected" "Not detected" CAB018654 Uncertain NA NA "Cluster 85: Liver - Metabolism" "Cluster 39: CACO-2 - Unknown function" "Cluster 22: Epithelial cell types - Mixed function" "CAB018654: AB_2088699" "unprognostic (1.71e-2)" "unprognostic (7.86e-2)" "unprognostic (2.57e-2)" "unprognostic (2.89e-1)" "unprognostic (5.45e-3)" "unprognostic (6.34e-2)" "unprognostic (3.08e-1)" "unprognostic (6.24e-3)" "unprognostic (1.11e-1)" "unprognostic (1.01e-1)" "unprognostic (1.41e-1)" "unprognostic (1.03e-1)" "unprognostic (4.21e-2)" "unprognostic (6.70e-2)" "unprognostic (2.20e-1)" "unprognostic (4.77e-1)" "unprognostic (1.28e-1)" 18.5 0.6 0.2 0.0 0.2 0.0 14.7 0.1 0.3 3.6 0.0 2.0 0.6 2.4 0.6 1.9 1.2 0.7 10.7 0.2 0.4 1.4 66.1 12.2 0.0 0.3 0.4 0.5 0.6 0.0 0.5 0.3 0.3 0.7 0.1 0.3 1.8 0.6 4.1 13.9 19.8 0.0 0.1 0.1 1.8 0.3 0.2 0.2 2.0 0.2 0.1 63.6 2.2 0.1 0.3 2.1 0.2 0.0 0.5 0.1 11.7 0.0 0.1 0.7 0.3 36.9 1.6 0.3 9.6 0.0 8.8 11.4 0.7 7.3 0.3 0.0 1.0 0.5 2.6 5.5 0.2 0.3 11.5 0.0 19.5 0.3 1.4 0.4 19.1 0.3 2.3 0.3 0.1 0.7 0.1 0.4 0.2 12.1 2.9 1.2 0.0 0.4 0.0 2.4 0.6 0.3 1.7 14.7 3.8 35.6 0.4 0.2 1.0 1.6 0.5 5.2 0.0 0.7 0.2 0.5 0.0 0.3 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.1 0.3 0.2 0.4 0.3 0.4 0.3 0.1 0.2 0.1 21.9 0.0 0.0 0.0 0.1 0.5 2.4 0.0 0.0 0.0 0.4 0.5 0.6 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 3.4 1.1 13.7 0.0 0.0 0.1 0.2 0.0 0.2 0.0 5.9 0.0 0.0 0.0 9.9 0.0 0.0 0.4 0.0 0.0 0.0 0.7 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.1 0.0 0.4 0.0 0.1 0.0 0.0 16.4 CYP1A2 "CP12, P3-450" ENSG00000140505 "Cytochrome P450 family 1 subfamily A member 2" P05177 15 74748845-74756607 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted membrane proteins" "Fatty acid metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Lyase, Monooxygenase, Oxidoreductase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 313 "liver: 513.4" "Cell type enriched" "Detected in some" 57 "Hepatocytes: 85.7" "Group enriched" "Detected in some" 22 "liver cancer: 25.3;urothelial cancer: 6.5" "Low region specificity" "Detected in some" "Immune cell enhanced" "Detected in some" "neutrophil: 2.1" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "SK-BR-3: 2.3" "Not detected" "Not detected" "Not detected" "Not detected" CAB016531 Enhanced NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 2: Hepatocytes - Metabolism" "CAB016531: AB_629359" "unprognostic (1.54e-4)" "unprognostic (1.29e-1)" "unprognostic (1.98e-1)" "unprognostic (1.74e-1)" "unprognostic (1.59e-2)" "unprognostic (1.76e-1)" "unprognostic (1.17e-2)" "unprognostic (5.48e-2)" "unprognostic (2.33e-2)" "unprognostic (7.41e-2)" "unprognostic (2.53e-1)" 0.2 0.3 0.5 0.2 0.5 1.0 0.1 1.6 0.8 0.0 0.2 0.0 0.2 0.2 0.4 0.1 0.2 0.2 0.1 0.5 0.5 0.2 513.4 0.4 0.3 0.6 0.5 0.1 0.0 0.0 0.0 0.7 0.6 0.1 0.1 0.4 0.2 0.3 0.3 0.6 0.2 0.0 0.1 0.3 0.2 0.3 0.6 0.1 1.4 0.0 0.1 0.1 0.0 1.3 0.4 0.3 0.8 0.5 0.1 0.0 0.6 0.2 0.0 0.0 0.1 0.3 0.4 0.8 0.1 0.0 0.6 0.4 0.0 0.0 0.0 0.1 0.4 0.9 0.6 0.1 0.0 0.7 0.3 0.1 0.1 0.0 0.0 0.3 0.1 1.3 0.7 1.3 0.0 0.2 0.9 0.3 0.4 0.3 0.2 0.9 0.8 0.3 0.1 0.7 0.7 0.3 0.6 2.3 0.1 0.6 0.5 0.2 0.2 0.3 0.4 0.3 0.3 0.3 0.2 0.5 0.3 0.9 0.3 1.5 0.3 0.5 0.2 0.2 0.1 0.3 0.2 0.1 0.1 0.5 0.2 0.2 2.1 0.4 0.2 0.4 0.1 0.1 0.5 0.5 1.6 0.8 0.5 0.5 0.6 0.5 0.6 0.1 0.6 1.3 0.0 0.0 0.0 0.0 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.3 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 85.7 0.1 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 CYP1B1 "CP1B, GLC3A" ENSG00000138061 "Cytochrome P450 family 1 subfamily B member 1" Q16678 2 38066973-38109902 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Fatty acid metabolism, Lipid metabolism, Steroid metabolism" "Lyase, Monooxygenase, Oxidoreductase" "Disease variant, Glaucoma, Peters anomaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Peritubular cells: 170.8;Prostatic glandular cells: 747.6;Urothelial cells: 498.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 7 "classical monocyte: 156.9" "Lineage enriched" "Detected in many" 24 "monocytes: 156.9" "Cell line enhanced" "Detected in many" "ASC diff: 128.7;ASC TERT1: 136.8;HSkMC: 551.3;hTERT-RPE1: 128.9;SiHa: 270.0;U-87 MG: 142.2" "Low region specificity" "Detected in many" "Region enhanced" "Detected in all" "spinal cord: 34.6" "CAB011705, HPA026863" Approved Uncertain Mitochondria NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 89: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 22: Epithelial cell types - Mixed function" Mitochondria "CAB011705: AB_731810, HPA026863: AB_10600900" "unprognostic (7.25e-3)" "unprognostic (2.28e-1)" "unprognostic (1.24e-3)" "unprognostic (2.27e-1)" "unprognostic (2.04e-2)" "unprognostic (1.68e-1)" "unprognostic (5.45e-2)" "unprognostic (1.80e-1)" "unprognostic (3.38e-1)" "unprognostic (9.69e-2)" "unprognostic (4.20e-1)" "unprognostic (1.84e-1)" "prognostic unfavorable (4.39e-6)" "unprognostic (1.87e-3)" "unprognostic (1.81e-1)" "unprognostic (6.67e-2)" "prognostic unfavorable (2.76e-4)" 28.4 12.0 2.7 31.9 6.2 2.0 29.4 1.6 8.9 34.9 10.4 3.7 2.2 41.0 19.5 7.6 44.9 23.8 29.2 2.5 2.3 24.1 7.0 16.8 11.6 3.6 2.9 5.6 7.2 0.9 14.8 4.5 3.0 34.7 2.1 1.2 4.3 39.2 3.4 6.3 5.8 35.1 3.6 27.3 15.9 8.0 7.3 28.3 8.7 5.5 1.9 35.0 6.7 1.5 7.0 71.9 2.3 0.0 128.7 136.8 0.4 0.6 4.4 1.3 12.3 0.2 30.1 0.0 19.1 17.8 3.1 58.7 0.3 4.0 2.3 5.5 3.8 0.0 21.2 0.0 36.0 0.2 0.1 551.3 55.3 30.7 1.4 128.9 0.0 0.3 0.7 0.2 0.7 29.2 0.3 22.5 7.5 10.4 14.2 0.1 0.0 0.2 13.4 0.9 0.5 2.1 270.0 38.8 0.0 7.5 49.4 10.8 0.0 1.1 0.2 107.9 0.1 0.3 0.2 0.0 142.2 0.1 11.8 1.6 156.9 0.0 0.1 23.2 0.0 0.1 0.1 0.0 1.5 0.0 0.1 0.1 6.5 0.1 18.6 0.7 0.1 70.2 2.7 6.2 1.6 8.9 2.5 2.3 3.6 2.9 3.0 3.6 7.3 1.5 56.8 19.2 66.3 0.0 1.7 17.7 118.4 86.9 8.0 0.7 18.3 42.0 3.4 0.0 79.7 46.0 0.0 0.3 1.1 0.9 15.6 6.0 15.1 11.7 100.4 103.8 1.8 0.0 4.5 0.5 0.8 114.1 3.6 28.2 3.8 0.1 7.5 12.2 12.6 0.0 0.3 1.3 4.1 103.0 50.6 12.1 159.7 112.2 17.8 64.6 140.1 1.6 3.1 0.0 0.2 0.6 0.1 170.8 0.3 747.6 0.1 1.6 11.2 0.5 19.7 4.5 32.7 12.6 2.6 2.4 14.2 0.3 2.4 1.3 1.0 498.7 CYP2S1 ENSG00000167600 "Cytochrome P450 family 2 subfamily S member 1" Q96SQ9 19 41193210-41207539 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Fatty acid metabolism, Lipid metabolism" "Isomerase, Lyase, Monooxygenase, Oxidoreductase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 8 "intestine: 101.3;stomach 1: 120.4" "Cell type enhanced" "Detected in many" "Distal enterocytes: 31.0;Gastric mucus-secreting cells: 110.6;Intestinal goblet cells: 29.2;Langerhans cells: 73.0;Proximal enterocytes: 50.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 9 "classical monocyte: 24.7;myeloid DC: 84.4" "Group enriched" "Detected in many" 131 "dendritic cells: 84.4;monocytes: 24.7" "Cell line enhanced" "Detected in many" "A549: 99.4;CACO-2: 49.8;HaCaT: 50.3;NTERA-2: 69.6;OE19: 158.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA049227, HPA069248" Approved Supported "Endoplasmic reticulum" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 9: Intestine - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 41: Macrophages - Immune response" "Endoplasmic reticulum" "HPA049227: AB_2680681, HPA069248: AB_2732128" "unprognostic (1.49e-2)" "unprognostic (7.45e-2)" "unprognostic (2.45e-2)" "unprognostic (6.03e-2)" "unprognostic (3.93e-2)" "unprognostic (7.46e-2)" "unprognostic (1.27e-2)" "unprognostic (4.85e-2)" "unprognostic (2.18e-1)" "unprognostic (1.54e-2)" "unprognostic (6.25e-3)" "unprognostic (1.25e-1)" "prognostic unfavorable (1.60e-6)" "unprognostic (1.06e-1)" "unprognostic (1.10e-1)" "unprognostic (1.02e-1)" "unprognostic (7.66e-2)" 1.8 1.1 1.4 6.7 1.4 1.8 0.9 3.1 1.5 2.7 1.2 26.7 101.3 0.5 0.2 14.5 6.3 5.5 0.5 1.3 4.1 1.1 1.4 7.1 1.7 6.3 10.0 0.3 0.6 0.7 1.2 1.6 6.1 1.3 18.6 0.2 5.0 0.9 0.2 3.7 65.3 1.7 2.2 6.1 120.4 0.8 3.6 3.2 0.6 0.2 13.2 3.6 4.0 2.5 3.8 99.4 0.0 0.1 0.0 0.0 4.5 0.6 0.8 1.0 0.2 49.8 13.6 0.2 10.4 0.7 0.1 50.3 16.6 25.0 0.4 0.0 0.3 12.9 5.1 19.1 19.4 0.0 0.4 0.8 1.4 1.4 0.8 0.2 0.8 4.3 5.8 0.2 0.0 2.0 0.3 0.2 69.6 158.6 12.5 0.2 0.0 0.9 1.5 20.4 0.1 0.6 9.1 0.0 0.0 27.8 12.2 4.7 10.6 0.1 4.0 1.7 0.0 0.5 0.0 0.0 0.5 2.1 0.1 0.0 24.7 0.0 0.0 5.9 0.4 0.0 0.0 0.1 84.4 0.0 0.0 0.0 0.2 0.1 3.7 3.2 0.0 11.4 1.4 1.4 3.1 1.5 1.3 4.1 6.3 10.0 6.1 2.2 3.6 2.5 0.3 0.0 6.9 1.0 0.7 2.5 2.0 18.2 23.3 0.0 0.1 0.3 1.2 0.0 7.6 1.8 0.0 24.9 0.1 31.0 0.0 0.7 0.3 7.4 0.3 0.4 0.0 0.0 0.4 1.0 1.1 0.8 110.6 0.3 1.3 0.1 0.4 0.0 14.5 0.0 0.5 29.2 0.0 5.7 73.0 0.0 0.0 16.0 0.0 1.0 7.2 0.0 0.0 0.5 0.1 23.7 22.3 0.0 0.4 0.5 50.7 0.2 10.8 0.0 0.0 0.3 0.9 0.1 0.4 4.0 2.8 10.3 0.3 0.0 14.1 0.5 DDC AADC ENSG00000132437 "Dopa decarboxylase" P20711 7 50458436-50565405 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Catecholamine biosynthesis" "Decarboxylase, Lyase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 165.8;kidney: 314.9;retina: 175.6" "Group enriched" "Detected in many" 4 "Enteroendocrine cells: 410.3;Proximal enterocytes: 391.5;Proximal tubular cells: 429.5;Rod photoreceptor cells: 498.9" "Group enriched" "Detected in many" 5 "colorectal cancer: 23.5;liver cancer: 13.4;pancreatic cancer: 6.4;renal cancer: 18.7;stomach cancer: 9.9" "Group enriched" "Detected in many" 9 "midbrain: 86.3;pons: 29.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "CACO-2: 54.5;Hep G2: 49.3;OE19: 83.6;SCLC-21H: 130.9;SH-SY5Y: 135.9" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "midbrain: 74.5;pons: 29.4" HPA017742 Enhanced Approved "Actin filaments" NA NA 120000 "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Actin filaments" "HPA017742: AB_1847832" "unprognostic (1.04e-1)" "unprognostic (3.68e-2)" "unprognostic (2.57e-2)" "unprognostic (3.49e-5)" "unprognostic (1.17e-1)" "unprognostic (1.03e-1)" "unprognostic (1.28e-1)" "unprognostic (5.15e-2)" "unprognostic (4.69e-2)" "unprognostic (5.44e-2)" "unprognostic (9.36e-3)" "unprognostic (5.24e-2)" "unprognostic (1.76e-3)" "unprognostic (1.60e-1)" "unprognostic (3.55e-1)" "unprognostic (7.65e-2)" "unprognostic (1.16e-1)" 0.5 48.9 0.1 2.3 0.7 0.0 1.0 0.0 0.6 0.0 0.2 36.5 154.8 0.0 9.1 0.1 0.0 0.1 0.0 0.2 2.2 314.9 54.6 2.0 0.1 6.1 86.3 0.8 15.8 0.0 0.0 0.0 29.4 0.6 37.5 175.6 0.0 0.0 0.0 0.1 165.8 1.7 0.0 0.1 18.1 1.5 1.9 0.0 0.2 0.0 0.0 0.0 0.1 0.2 0.0 1.7 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 54.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 49.3 0.0 0.0 11.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.1 83.6 0.0 0.0 0.0 0.7 1.3 0.0 130.9 135.9 0.0 4.4 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.7 0.0 0.6 0.2 2.2 6.1 86.3 29.4 0.0 1.9 0.2 0.0 0.0 12.2 0.0 2.5 0.0 0.0 0.0 0.0 89.3 0.1 0.1 0.4 2.8 0.6 3.7 41.7 0.0 0.0 34.4 25.4 0.1 6.6 0.1 0.0 1.8 410.3 0.0 0.3 0.9 0.1 0.1 0.0 0.4 0.0 0.0 1.1 67.2 0.1 3.3 0.4 67.8 0.0 1.3 0.0 5.4 0.0 2.5 0.0 0.0 0.0 45.1 0.0 0.0 0.1 0.2 31.8 0.0 0.0 0.3 391.5 429.5 0.0 498.9 0.0 0.0 0.0 4.0 0.4 0.0 0.0 0.1 1.3 0.1 88.7 0.2 DDT "D-DT, DDCT, MIF-2, MIF2" ENSG00000099977 "D-dopachrome tautomerase" P30046 22 23971365-23979828 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Melanin biosynthesis" Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 835.9" "Cell type enhanced" "Detected in all" "Hepatocytes: 4869.6;Proximal tubular cells: 1415.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HEK 293: 262.9" "HPA049871, HPA074115" Approved Approved Mitochondria NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 85: Liver - Metabolism" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 2: Hepatocytes - Metabolism" Mitochondria "HPA049871: AB_2680926, HPA074115: " "unprognostic (1.77e-2)" "unprognostic (1.13e-1)" "unprognostic (1.40e-1)" "unprognostic (1.22e-2)" "unprognostic (8.09e-2)" "unprognostic (4.00e-3)" "unprognostic (2.02e-3)" "unprognostic (6.58e-2)" "unprognostic (4.66e-2)" "unprognostic (2.23e-2)" "unprognostic (1.96e-1)" "unprognostic (6.06e-3)" "unprognostic (1.12e-1)" "unprognostic (7.34e-2)" "unprognostic (3.30e-1)" "unprognostic (3.81e-1)" "unprognostic (2.61e-3)" 125.7 126.7 29.6 15.1 30.6 39.6 99.0 33.1 38.0 69.6 28.7 128.5 44.2 62.6 16.2 119.1 67.3 6.3 167.0 28.9 32.2 218.2 835.9 69.2 13.7 30.7 29.6 83.0 260.9 24.3 47.7 10.7 30.7 109.0 24.2 12.8 82.7 15.7 129.3 89.8 120.7 8.6 30.7 66.3 176.2 39.2 32.9 12.3 80.1 15.7 11.9 86.8 76.4 33.9 107.6 44.8 15.4 34.9 29.0 24.9 92.6 30.4 20.7 26.1 27.1 39.8 30.6 101.9 27.8 16.1 37.7 86.3 38.3 38.1 17.1 43.6 262.9 60.8 58.9 88.3 28.9 136.2 58.8 25.5 28.5 26.3 23.1 27.9 28.7 16.0 56.8 40.2 26.9 53.0 30.1 123.1 46.2 94.4 134.2 65.3 27.0 148.9 46.4 39.2 51.7 49.2 62.8 117.7 95.9 20.6 30.8 42.3 33.1 26.8 59.9 27.8 32.2 122.6 43.9 65.1 53.1 49.7 52.5 63.5 92.9 72.4 46.0 82.8 47.5 75.3 55.3 49.1 87.8 70.7 49.2 48.9 58.3 61.6 79.1 130.4 74.5 78.8 29.6 30.6 33.1 38.0 28.9 32.2 30.7 29.6 30.7 30.7 32.9 33.9 116.9 83.3 86.3 11.1 178.3 138.9 220.5 278.8 176.4 58.4 266.6 379.7 21.3 499.0 153.2 242.8 89.6 202.6 134.1 533.1 718.1 237.2 202.1 150.8 126.4 103.4 259.6 230.2 9.1 375.7 288.2 103.9 163.1 260.3 129.4 97.1 154.9 4869.6 281.0 43.7 11.0 402.8 187.2 240.4 162.2 411.0 117.1 172.2 158.3 9.4 235.8 119.6 135.9 6.0 18.8 233.6 395.1 110.6 166.1 257.5 935.1 1415.8 97.6 100.0 78.9 109.5 127.6 117.9 43.8 280.6 188.0 299.8 140.3 212.5 558.7 291.3 DERA "CGI-26, DEOC" ENSG00000023697 "Deoxyribose-phosphate aldolase" Q9Y315 12 15911302-16037381 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 104.6" "Cell type enhanced" "Detected in all" "Proximal tubular cells: 152.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA055897 Supported Nucleoplasm NA NA 320000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "HPA055897: AB_2682963" "unprognostic (3.05e-1)" "unprognostic (1.26e-1)" "unprognostic (1.06e-2)" "unprognostic (7.26e-2)" "unprognostic (8.12e-2)" "unprognostic (7.74e-2)" "unprognostic (1.36e-1)" "unprognostic (1.47e-2)" "unprognostic (2.76e-1)" "unprognostic (1.87e-1)" "prognostic unfavorable (1.32e-4)" "unprognostic (2.13e-1)" "unprognostic (1.09e-1)" "unprognostic (8.74e-2)" "unprognostic (2.17e-2)" "prognostic favorable (3.64e-5)" "unprognostic (3.66e-2)" 21.1 16.3 13.7 17.3 16.0 17.6 21.1 15.8 17.1 16.7 21.5 39.9 41.1 16.2 27.0 30.4 15.0 20.3 18.1 13.4 16.0 74.1 104.6 25.0 20.3 16.5 14.8 6.8 27.2 15.6 12.1 20.7 16.4 13.5 42.1 28.1 17.9 14.1 27.8 25.3 54.0 20.4 15.4 17.0 21.7 9.7 15.2 19.8 27.9 29.6 22.7 18.3 18.2 17.1 63.6 51.4 40.0 36.6 27.1 60.3 80.6 36.6 35.2 48.7 63.2 63.9 118.1 44.3 31.3 47.2 44.1 43.8 43.4 47.6 84.7 71.3 25.6 37.6 24.1 60.6 38.7 40.7 25.2 40.8 54.9 40.9 81.0 42.2 71.6 36.2 5.3 13.1 92.1 24.1 30.6 34.5 86.8 37.3 25.6 45.8 85.5 26.8 125.0 23.2 29.5 49.9 69.3 23.4 75.4 158.2 124.5 50.6 66.3 53.6 33.5 24.4 39.0 13.6 21.4 76.9 66.6 41.1 39.6 15.2 58.4 36.2 16.6 68.4 18.2 29.4 17.7 17.7 74.9 29.9 19.3 15.5 15.8 46.0 76.4 40.4 38.1 41.9 13.7 16.0 15.8 17.1 13.4 16.0 16.5 14.8 16.4 15.4 15.2 17.1 37.2 44.8 28.4 20.2 19.4 29.3 31.6 55.3 21.6 4.8 22.4 18.8 13.5 27.1 43.1 12.9 14.6 65.7 22.1 51.6 109.5 64.3 55.8 27.8 32.3 28.3 26.5 28.2 8.6 59.3 69.9 23.9 14.3 52.9 8.8 30.6 36.4 52.2 61.0 3.3 5.9 44.7 54.9 46.7 26.4 6.7 24.5 44.8 72.9 30.9 47.4 29.8 14.4 28.6 18.9 74.6 49.6 30.5 30.7 19.1 140.0 152.3 27.3 29.9 6.6 17.4 27.5 8.5 16.7 35.5 25.9 71.3 13.9 49.0 42.9 34.0 DGLUCY "C14orf159, FLJ39975" ENSG00000133943 "D-glutamate cyclase" Q7Z3D6 14 91060333-91225632 "Enzymes, Predicted intracellular proteins" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "tongue: 163.6" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 28.9;Collecting duct cells: 29.5;Cytotrophoblasts: 30.9;Endometrial ciliated cells: 29.4;Granulosa cells: 49.8;Hofbauer cells: 31.7;Theca cells: 35.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 200.5" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA041423, HPA052932" Approved Supported Cytosol NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 39: Non-specific - Mitochondria" "Cluster 2: Karpas-707 - Immune response" "Cluster 40: Granulosa cells - Unknown function" Cytosol "HPA041423: AB_10795540, HPA052932: AB_2681991" "unprognostic (5.02e-2)" "unprognostic (1.01e-2)" "unprognostic (1.56e-1)" "prognostic favorable (4.28e-4)" "unprognostic (1.28e-1)" "unprognostic (2.26e-1)" "unprognostic (3.58e-2)" "prognostic favorable (9.48e-5)" "unprognostic (3.56e-1)" "prognostic favorable (7.28e-4)" "unprognostic (2.30e-1)" "unprognostic (1.74e-1)" "prognostic favorable (3.77e-15)" "unprognostic (1.50e-1)" "unprognostic (9.51e-2)" "unprognostic (2.75e-2)" "unprognostic (2.57e-3)" 23.9 32.2 38.5 21.4 46.0 21.7 16.7 53.5 49.2 25.0 76.1 33.5 25.1 26.0 17.2 28.4 38.6 22.6 122.3 36.6 39.8 35.6 24.9 25.0 21.6 45.5 51.3 22.9 16.8 47.9 21.5 16.6 42.1 22.8 30.4 8.3 32.2 34.1 143.0 25.6 23.7 32.0 38.0 33.6 38.1 19.0 45.4 27.3 30.1 163.6 19.9 31.9 20.2 45.2 6.2 16.4 8.0 20.1 32.8 30.6 21.0 6.6 17.7 19.3 19.6 10.9 46.7 41.3 46.0 18.8 24.9 18.0 23.0 24.7 7.9 22.8 9.5 27.7 9.1 13.8 47.8 28.5 38.2 47.5 10.5 10.6 4.0 25.3 34.6 22.8 14.0 54.4 18.4 1.4 22.7 27.0 16.4 0.8 1.4 38.2 15.7 30.9 32.7 25.9 22.4 11.2 10.4 17.8 7.3 8.4 32.0 24.5 24.7 5.7 4.8 17.1 5.9 30.9 23.8 14.0 29.6 36.8 3.8 67.5 48.8 30.8 30.1 69.4 30.3 34.0 19.3 24.5 72.9 22.4 15.9 20.0 200.5 21.0 60.7 22.0 45.2 29.0 38.5 46.0 53.5 49.2 36.6 39.8 45.5 51.3 42.1 38.0 45.4 45.2 19.2 28.9 16.4 0.0 4.3 0.0 0.0 0.0 0.0 0.0 11.5 13.2 0.0 0.0 5.6 29.5 0.0 30.9 12.5 0.0 21.5 17.6 0.0 29.4 14.8 6.2 0.0 0.0 0.0 5.8 15.8 7.4 0.0 25.0 7.6 49.8 0.0 0.0 31.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.2 0.0 0.0 7.2 0.0 0.0 0.0 0.0 6.3 0.0 0.0 2.7 0.0 0.0 17.0 5.1 0.0 0.0 0.0 5.8 0.0 0.0 0.0 0.0 16.8 8.7 35.6 0.0 0.0 ECHDC1 dJ351K20.2 ENSG00000093144 "Ethylmalonyl-CoA decarboxylase 1" Q9NTX5 6 127288712-127343609 "Enzymes, Plasma proteins, Predicted intracellular proteins" Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Proximal tubular cells: 230.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035445, HPA035446" Uncertain Approved Vesicles NA NA 56000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 1: K-562 - Erythropoiesis" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Vesicles "HPA035445: AB_10669860, HPA035446: AB_2732468" "unprognostic (9.57e-2)" "unprognostic (1.63e-2)" "unprognostic (2.46e-3)" "unprognostic (1.34e-1)" "unprognostic (4.09e-1)" "unprognostic (3.68e-2)" "unprognostic (5.03e-3)" "unprognostic (4.89e-3)" "unprognostic (4.97e-2)" "unprognostic (1.76e-1)" "unprognostic (3.99e-1)" "unprognostic (9.97e-2)" "unprognostic (8.21e-3)" "unprognostic (6.83e-2)" "unprognostic (2.86e-1)" "unprognostic (1.39e-1)" "unprognostic (1.40e-2)" 92.9 29.4 21.8 36.8 24.5 16.2 37.3 26.4 28.6 36.4 32.3 58.4 46.8 21.4 23.0 33.5 23.2 27.5 42.6 22.0 27.0 92.5 93.8 56.8 41.3 28.1 24.7 21.1 27.9 26.2 14.1 36.2 28.5 33.8 53.8 30.0 46.3 28.4 39.3 22.7 40.7 33.4 24.4 28.4 37.0 18.2 24.7 41.1 38.7 52.2 42.6 43.4 23.4 32.3 58.3 45.6 64.0 59.3 92.9 87.7 54.1 92.7 112.1 78.0 99.0 79.7 43.1 87.6 77.8 88.6 88.4 46.9 0.1 69.6 98.3 52.4 43.3 116.9 58.4 128.3 82.6 158.0 63.4 99.6 81.9 73.1 61.6 70.6 71.8 63.2 147.6 51.6 105.7 55.1 105.7 73.5 52.9 29.0 55.8 49.0 78.7 72.3 142.8 70.8 73.3 71.2 52.1 1.8 131.3 48.3 1.8 182.6 75.2 47.8 76.9 121.8 104.8 65.7 141.0 116.3 87.2 136.4 114.7 19.0 71.6 24.0 23.4 57.5 24.7 28.6 19.8 22.9 66.6 29.2 23.7 24.2 28.6 15.3 43.1 50.5 22.1 43.9 21.8 24.5 26.4 28.6 22.0 27.0 28.1 24.7 28.5 24.4 24.7 32.3 37.0 96.1 114.0 32.3 59.7 26.1 42.3 94.2 35.3 26.4 30.8 28.3 60.8 32.9 102.4 31.3 31.3 106.8 49.3 35.6 127.2 76.1 64.7 47.0 48.3 32.6 13.8 22.9 47.4 79.5 85.6 45.8 38.2 40.2 43.7 32.9 26.0 68.8 85.8 28.6 41.0 35.7 59.0 48.4 38.7 24.4 32.9 55.9 35.6 40.3 55.3 33.5 47.4 55.3 95.0 54.4 41.1 31.2 48.3 31.1 74.4 230.3 47.0 42.3 26.3 55.7 33.0 27.6 28.6 34.7 22.9 65.5 46.3 88.2 56.9 52.7 ECHS1 SCEH ENSG00000127884 "Enoyl-CoA hydratase, short chain 1" P30084 10 133362485-133373354 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" Lyase "Disease variant, FDA approved drug targets, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 1128.7" "Cell type enhanced" "Detected in all" "Hepatocytes: 1476.3;Proximal tubular cells: 2336.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003783, HPA021995, HPA022476" Enhanced Enhanced Mitochondria NA NA 1200000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 85: Liver - Metabolism" "Cluster 39: CACO-2 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "CAB003783: , HPA021995: AB_1847974, HPA022476: AB_1847975" "unprognostic (3.68e-1)" "unprognostic (2.46e-3)" "unprognostic (9.57e-2)" "unprognostic (4.70e-2)" "unprognostic (1.59e-1)" "unprognostic (3.14e-1)" "unprognostic (2.51e-3)" "unprognostic (2.30e-1)" "unprognostic (1.82e-2)" "unprognostic (2.28e-2)" "unprognostic (1.60e-1)" "unprognostic (1.27e-1)" "prognostic favorable (8.57e-5)" "unprognostic (2.84e-2)" "unprognostic (1.19e-2)" "unprognostic (3.04e-2)" "unprognostic (2.50e-2)" 302.4 127.1 127.7 53.7 127.8 43.9 116.9 131.3 136.1 59.8 149.7 143.1 171.6 47.0 89.3 107.9 90.5 66.7 226.4 133.1 129.9 481.7 1128.7 48.5 52.4 129.4 129.9 71.3 96.8 98.7 74.3 73.6 128.8 102.0 104.6 39.8 163.4 123.2 294.3 68.2 153.6 59.4 130.3 48.4 84.5 52.6 134.6 40.0 88.5 271.6 59.0 87.4 57.8 136.0 185.1 229.2 120.4 303.4 173.0 111.4 110.5 132.2 175.9 183.2 154.1 509.5 174.0 139.2 111.9 151.4 94.4 167.7 160.2 136.1 132.0 107.4 281.2 138.5 128.1 367.2 145.0 180.4 93.5 124.5 115.9 121.2 153.6 160.8 165.1 98.3 127.8 117.4 181.6 443.9 90.7 352.0 84.4 289.8 272.1 152.8 146.4 74.6 227.8 236.0 78.1 123.4 137.0 224.1 178.9 69.4 174.8 171.5 132.1 81.3 115.9 169.9 177.4 87.0 58.8 159.8 192.4 98.8 68.7 96.1 184.7 86.8 105.5 212.2 137.6 178.7 117.8 115.8 242.6 148.9 119.3 115.8 19.8 166.0 168.1 104.9 123.0 233.0 127.7 127.8 131.3 136.1 133.1 129.9 129.4 129.9 128.8 130.3 134.6 136.0 99.2 44.8 82.7 16.3 60.5 68.2 86.9 271.8 62.6 57.0 98.5 119.6 255.2 210.1 161.5 174.7 6.2 470.2 34.0 298.6 565.4 162.8 29.9 148.9 92.7 71.4 131.7 72.2 11.6 101.1 163.5 92.5 87.7 226.4 91.2 120.0 88.5 1476.3 221.1 45.4 11.0 223.0 175.0 92.1 61.5 39.1 77.6 88.0 135.2 10.3 113.0 145.2 45.3 10.6 24.3 107.8 248.6 91.7 57.5 88.0 486.2 2336.5 93.2 55.2 85.5 57.0 98.8 52.9 66.1 125.2 76.3 299.1 62.5 220.0 317.2 127.8 EHHADH ECHD ENSG00000113790 "Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase" Q08426 3 185190624-185281990 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" "Isomerase, Lyase, Multifunctional enzyme, Oxidoreductase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 11 "kidney: 144.3;liver: 344.5" "Group enriched" "Detected in many" 10 "Hepatocytes: 289.0;Proximal tubular cells: 147.1" "Group enriched" "Detected in all" 7 "liver cancer: 42.2;renal cancer: 25.4" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036401, HPA042021" Enhanced NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 39: CACO-2 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA036401: AB_10670165, HPA042021: AB_2677801" "unprognostic (1.20e-1)" "unprognostic (5.99e-2)" "unprognostic (2.17e-3)" "unprognostic (2.69e-2)" "unprognostic (6.82e-2)" "unprognostic (1.48e-1)" "unprognostic (4.79e-3)" "unprognostic (1.25e-1)" "unprognostic (1.73e-1)" "unprognostic (3.89e-2)" "unprognostic (3.19e-3)" "unprognostic (1.87e-1)" "prognostic favorable (1.28e-5)" "unprognostic (1.93e-1)" "unprognostic (1.53e-1)" "unprognostic (2.96e-2)" "unprognostic (2.80e-1)" 10.8 4.3 2.1 3.0 2.9 1.2 4.1 3.9 2.7 3.5 9.2 14.2 21.5 2.8 3.5 5.5 3.6 4.4 10.7 2.1 3.1 144.3 344.5 4.3 2.1 3.2 4.1 2.6 9.9 7.8 1.5 3.2 3.0 6.3 10.8 1.6 5.7 2.2 1.7 4.5 12.9 3.7 2.5 3.7 10.4 2.7 3.1 2.1 6.5 5.6 2.8 3.6 2.1 2.8 12.3 5.0 1.4 0.0 7.3 6.1 1.5 5.7 1.8 3.7 4.1 21.9 7.5 0.0 22.1 5.7 1.4 5.8 0.0 4.8 7.6 16.2 5.2 8.6 1.3 22.5 4.7 1.0 0.2 8.7 6.0 3.7 3.4 5.0 5.5 0.0 5.7 6.1 7.2 6.4 0.2 5.1 3.0 4.3 6.3 0.0 9.9 0.5 15.4 6.8 4.4 6.4 11.2 6.4 10.5 12.1 23.7 10.1 2.6 2.4 3.6 1.9 0.5 1.7 5.6 0.5 0.8 3.9 4.0 0.1 0.9 0.0 0.6 0.8 0.4 0.5 0.4 0.9 2.4 0.0 0.6 1.0 0.0 1.2 0.8 1.0 0.6 0.4 2.1 2.9 3.9 2.7 2.1 3.1 3.2 4.1 3.0 2.5 3.1 2.8 4.9 16.0 10.9 20.9 4.5 1.5 1.4 1.9 1.2 0.7 3.2 2.3 19.2 17.2 3.9 20.2 4.2 8.9 0.4 17.8 19.6 2.1 0.2 6.5 5.1 3.9 7.7 9.7 4.9 6.8 2.9 1.6 8.6 3.1 0.0 6.1 13.6 289.0 4.4 0.0 5.7 12.8 0.0 10.5 1.0 0.7 0.6 2.7 3.6 4.7 9.4 1.9 0.0 3.5 8.0 3.7 9.3 0.4 0.8 2.5 15.0 147.1 4.0 1.2 0.0 1.1 2.4 3.7 4.2 4.9 0.4 1.4 2.2 3.6 10.8 1.8 ENO1 "ENO1L1, MBP-1, MPB1, PPH" ENSG00000074800 "Enolase 1" P06733 1 8861000-8879190 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Glycolysis, Plasminogen activation, Transcription, Transcription regulation" "DNA-binding, Lyase, Repressor" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Ductal cells: 2259.3;Extravillous trophoblasts: 2078.5;Muller glia cells: 2624.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB018614, HPA068284, HPA068721, CAB069394, CAB080034" Supported Enhanced "Plasma membrane,Cytosol" NA NA 310000000 "Cluster 39: Non-specific - mRNA processing" "Cluster 27: Brain & Skin - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 16: Pancreatic endocrine cells - Mixed function" "Plasma membrane, Cytosol" "CAB018614: AB_2099061, CAB069394: , CAB080034: , HPA068284: , HPA068721: AB_2732119" "unprognostic (6.51e-3)" "unprognostic (9.50e-3)" "unprognostic (3.56e-2)" "unprognostic (1.86e-1)" "prognostic unfavorable (2.71e-4)" "unprognostic (1.82e-2)" "prognostic unfavorable (1.30e-8)" "unprognostic (2.37e-2)" "unprognostic (5.58e-2)" "unprognostic (9.72e-2)" "unprognostic (1.67e-2)" "unprognostic (1.46e-1)" "unprognostic (7.53e-2)" "unprognostic (6.20e-2)" "unprognostic (1.97e-1)" "unprognostic (2.22e-1)" "unprognostic (1.36e-3)" 463.4 418.4 552.9 553.3 591.7 792.8 409.1 679.7 749.9 370.7 585.6 382.6 401.2 321.7 125.7 1049.4 281.6 302.0 328.2 638.1 599.6 1063.6 612.2 453.2 492.4 624.1 607.7 295.0 220.8 347.2 245.7 362.7 602.9 279.2 358.3 741.5 581.3 354.2 231.0 548.1 382.3 471.3 583.4 394.9 321.6 217.7 585.3 455.6 271.4 146.5 695.4 485.9 519.7 571.5 3637.0 3088.4 1461.8 1258.6 1194.2 1323.8 1316.6 1919.1 2110.9 4044.1 3767.4 1986.9 2041.5 2586.5 2496.8 2328.5 1651.8 1736.8 2511.5 5127.7 4081.0 1780.5 2645.9 2191.3 2848.0 2511.0 1789.6 4421.6 1290.1 1377.4 1526.1 3208.9 4825.9 3045.2 2630.1 1294.6 2444.4 982.3 2664.2 1784.1 1685.2 2354.5 1600.3 1290.4 3063.4 1712.4 2172.9 4259.0 4815.0 843.6 1961.4 1211.1 2251.0 3232.5 2407.8 1748.4 1621.8 1302.1 2424.7 2774.5 2444.5 2402.3 3328.3 2771.0 2120.4 3906.9 4313.8 3556.1 2388.6 195.9 1198.7 232.3 528.4 822.7 597.3 411.2 552.5 543.2 1216.4 386.1 443.4 466.0 230.6 635.3 830.6 336.1 700.0 2171.2 552.9 591.7 679.7 749.9 638.1 599.6 624.1 607.7 602.9 583.4 585.3 571.5 140.0 278.9 499.1 99.6 222.3 416.5 570.9 1939.8 348.8 178.2 242.7 324.6 69.6 283.1 657.4 606.9 70.9 1045.4 194.0 455.9 925.4 2259.3 281.3 205.3 227.7 314.3 189.0 145.4 32.0 1399.1 2078.5 303.5 144.8 248.4 297.2 408.6 133.5 351.7 1147.4 482.9 33.2 297.3 787.3 356.4 524.5 699.6 171.5 454.2 448.2 30.9 1558.2 2624.9 279.1 28.6 26.9 1433.6 366.9 135.1 211.0 555.7 742.2 1005.4 245.7 216.6 151.2 156.1 402.5 215.1 154.3 468.1 349.6 1001.8 285.6 609.8 528.4 444.2 ENO2 ENSG00000111674 "Enolase 2" P09104 12 6913745-6923698 "Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Glycolysis Lyase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 4 "retina: 1695.6" "Cell type enhanced" "Detected in many" "Bipolar cells: 318.2;Cone photoreceptor cells: 312.8;Horizontal cells: 429.0;Rod photoreceptor cells: 787.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "gdT-cell: 9.9;MAIT T-cell: 11.3;memory B-cell: 6.8;memory CD4 T-cell: 13.1;memory CD8 T-cell: 11.4;naive B-cell: 4.4;naive CD4 T-cell: 8.2;naive CD8 T-cell: 8.6;neutrophil: 7.0;T-reg: 7.5" "Group enriched" "Detected in many" 7 "B-cells: 6.8;granulocytes: 7.0;T-cells: 13.1" "Cell line enhanced" "Detected in many" "hTERT-RPE1: 537.4;U-87 MG: 398.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000063, HPA068284, HPA068721, CAB073539, CAB079023" Enhanced Supported Supported "Plasma membrane,Cytosol" NA NA 55000000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 46: Photoreceptor cells - Phototransduction" "Plasma membrane, Cytosol" "CAB000063: AB_2099322, CAB073539: , CAB079023: , HPA068284: , HPA068721: AB_2732119" "unprognostic (8.96e-2)" "unprognostic (8.28e-2)" "prognostic unfavorable (6.96e-4)" "unprognostic (1.28e-1)" "unprognostic (7.95e-3)" "unprognostic (1.39e-2)" "prognostic unfavorable (5.15e-4)" "unprognostic (1.48e-1)" "unprognostic (9.43e-2)" "unprognostic (1.58e-1)" "unprognostic (1.98e-1)" "unprognostic (2.02e-2)" "prognostic unfavorable (7.89e-11)" "unprognostic (7.61e-2)" "unprognostic (3.06e-1)" "unprognostic (8.10e-3)" "unprognostic (1.24e-1)" 25.6 46.7 280.8 20.0 289.7 9.6 20.2 291.2 400.7 55.9 97.5 74.0 10.2 40.1 12.6 15.3 40.2 17.9 53.7 295.0 289.4 27.8 7.7 33.8 26.3 289.4 189.9 29.7 9.0 43.6 124.4 10.4 282.2 34.9 15.5 1695.6 13.8 34.4 7.4 19.3 37.1 35.0 164.3 26.4 30.4 9.6 259.0 26.7 42.0 6.4 24.4 57.4 44.1 306.2 74.3 45.3 16.2 0.5 23.7 26.0 1.5 56.5 37.3 82.0 125.9 8.6 5.8 103.9 9.5 24.3 108.8 11.0 173.0 15.4 116.1 211.9 16.6 141.0 47.7 60.3 17.4 8.3 161.2 13.0 0.7 61.1 11.5 537.4 17.5 137.9 9.5 1.1 56.3 10.3 66.9 8.8 84.9 31.7 27.2 75.0 13.9 22.9 38.5 9.8 128.3 94.0 14.3 1.0 96.3 76.4 4.5 3.9 20.9 69.4 73.7 95.7 73.0 73.3 79.5 15.4 398.4 0.3 15.2 2.1 0.0 0.2 9.9 0.0 11.3 6.8 13.1 11.4 0.1 4.4 8.2 8.6 7.0 0.4 0.3 1.2 7.5 6.1 280.8 289.7 291.2 400.7 295.0 289.4 289.4 189.9 282.2 164.3 259.0 306.2 3.2 35.3 27.4 54.2 11.2 6.2 2.3 45.2 1.8 318.2 5.2 4.3 16.1 1.5 17.2 12.9 312.8 0.3 7.5 0.3 0.0 17.0 0.5 9.6 2.1 9.9 23.9 7.0 96.2 1.8 1.1 8.3 2.0 2.7 67.2 1.0 5.3 0.2 1.7 429.0 89.4 0.5 18.3 0.6 6.9 0.3 5.6 5.9 12.4 25.3 3.5 146.1 0.0 23.6 31.5 9.3 1.2 9.8 9.2 2.5 0.1 0.2 32.2 787.2 13.1 8.1 20.2 1.5 2.5 1.1 2.3 0.3 17.1 0.3 0.4 2.2 ENO3 ENSG00000108515 "Enolase 3" P13929 17 4948092-4957131 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Glycolysis Lyase "Disease variant, Glycogen storage disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 26 "skeletal muscle: 14758.3;tongue: 10771.0" "Group enriched" "Detected in many" 5 "Cardiomyocytes: 582.2;Skeletal myocytes: 248.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 263.8;HeLa: 120.0;HMC-1: 115.1;RH-30: 170.2;RPMI-8226: 96.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000793, HPA068284, HPA068721" Enhanced Supported "Plasma membrane,Cytosol" Yes No 86000000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 44: HDLM-2 - Immune response" "Cluster 37: Myocytes - Muscle contraction" "Plasma membrane, Cytosol" "HPA000793: AB_1078742, HPA068284: , HPA068721: AB_2732119" "unprognostic (7.35e-2)" "unprognostic (5.25e-2)" "prognostic unfavorable (7.33e-4)" "unprognostic (1.57e-1)" "unprognostic (1.29e-1)" "unprognostic (5.86e-2)" "unprognostic (5.68e-2)" "unprognostic (2.08e-2)" "unprognostic (8.12e-2)" "unprognostic (1.42e-1)" "unprognostic (6.04e-3)" "unprognostic (2.21e-2)" "unprognostic (4.63e-2)" "unprognostic (5.34e-2)" "unprognostic (3.48e-1)" "unprognostic (2.15e-1)" "unprognostic (4.50e-2)" 7.8 5.5 3.8 15.6 3.9 20.4 8.0 7.1 4.3 6.6 5.0 8.0 20.1 7.2 7.1 173.8 7.4 2.6 499.8 3.5 3.7 10.3 108.0 8.6 13.0 4.3 5.0 6.0 5.5 4.0 7.9 6.3 4.6 47.3 3.0 5.0 116.8 3.1 14758.3 8.3 15.6 2.8 4.1 16.9 10.1 9.3 4.3 5.8 10.3 10771.0 4.9 5.6 5.0 4.9 12.0 25.5 11.3 10.7 9.1 2.2 27.6 21.0 2.7 1.5 1.3 12.8 8.1 21.9 25.8 1.9 3.5 15.4 3.8 1.9 1.0 263.8 24.3 21.9 120.0 18.9 3.7 6.8 115.1 14.4 3.8 2.1 4.1 9.8 1.4 24.8 10.2 39.0 4.9 6.6 7.9 26.5 14.8 3.3 10.6 34.6 170.2 96.9 3.1 7.9 7.1 27.1 13.6 11.4 14.7 7.6 10.2 7.0 6.5 12.1 21.3 5.4 16.0 27.6 16.8 18.2 6.7 20.8 12.2 31.4 28.5 50.4 36.8 41.5 24.8 24.5 30.8 34.4 37.6 20.1 20.0 32.2 34.4 34.9 47.6 29.9 43.2 83.6 3.8 3.9 7.1 4.3 3.5 3.7 4.3 5.0 4.6 4.1 4.3 4.9 1.2 0.0 1.8 2.3 2.7 2.0 1.2 2.1 4.0 6.6 3.0 3.0 582.2 0.0 2.2 5.5 4.2 5.4 3.2 2.9 0.0 1.5 1.8 0.9 1.6 7.3 0.0 3.8 0.2 0.8 3.8 17.3 4.6 2.2 8.2 2.4 2.2 56.2 4.5 3.3 0.2 2.2 2.0 3.5 6.7 3.7 0.3 4.3 1.8 0.0 78.3 1.9 4.1 1.0 0.5 1.8 1.9 0.4 2.3 1.2 6.6 9.5 0.3 2.5 6.6 248.4 55.8 7.9 7.5 2.1 1.8 3.3 4.5 1.1 2.6 0.8 ENO4 "AC023283.3, C10orf134" ENSG00000188316 "Enolase 4" A6NNW6 10 116849499-116911788 "Enzymes, Predicted intracellular proteins" Glycolysis Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 11.5;choroid plexus: 4.7;fallopian tube: 5.0" "Cell type enhanced" "Detected in some" "Astrocytes: 16.3;Cone photoreceptor cells: 22.9;Early spermatids: 15.5;Endometrial ciliated cells: 15.8;Inhibitory neurons: 18.4;Late spermatids: 15.8;Oligodendrocytes: 62.4;Respiratory ciliated cells: 30.2" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA037937, HPA037938" Enhanced Approved Nucleoplasm,Mitochondria NA NA "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 49: Ciliated cells - Cilium organization" Mitochondria Nucleoplasm "HPA037937: AB_10697089, HPA037938: AB_2675746" "unprognostic (2.92e-3)" "unprognostic (1.39e-1)" "unprognostic (1.07e-1)" "unprognostic (6.55e-4)" "unprognostic (8.38e-5)" "unprognostic (1.88e-1)" "unprognostic (2.21e-1)" "unprognostic (5.18e-2)" "unprognostic (1.22e-1)" "unprognostic (2.23e-2)" "unprognostic (3.74e-3)" "unprognostic (2.06e-1)" "unprognostic (2.20e-3)" "unprognostic (1.18e-1)" "unprognostic (9.77e-3)" "unprognostic (9.87e-5)" "unprognostic (1.08e-2)" 0.2 0.3 1.7 0.0 5.3 0.0 0.4 1.7 3.4 0.4 4.7 0.3 0.0 0.6 1.3 0.1 5.0 0.3 0.1 2.1 2.6 0.6 1.3 0.6 0.1 4.8 4.5 0.5 0.6 1.0 1.0 0.0 3.5 0.3 0.1 2.0 0.2 0.4 0.0 0.2 0.2 0.2 2.6 0.2 0.3 2.5 4.0 0.1 0.7 0.0 0.0 0.1 0.2 11.5 0.3 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.2 0.0 0.1 0.3 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.2 0.0 0.0 0.0 0.6 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.2 0.0 0.2 0.0 0.0 0.2 0.8 0.0 0.2 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.7 5.3 1.7 3.4 2.1 2.6 4.8 4.5 3.5 2.6 4.0 11.5 0.0 0.0 0.0 16.3 0.0 0.1 0.3 0.8 0.6 4.9 0.4 0.3 0.3 0.0 0.4 0.0 22.9 0.3 0.0 0.2 0.0 0.5 15.5 15.8 0.7 0.1 1.8 0.0 12.2 0.2 0.2 0.7 0.0 1.1 0.0 0.5 0.0 0.0 0.0 5.0 18.4 0.0 0.0 0.0 0.6 15.8 1.2 0.2 0.0 8.4 0.6 1.3 0.0 4.5 62.4 0.2 0.1 0.7 0.0 0.1 0.3 0.8 30.2 8.4 0.0 1.0 0.5 9.4 2.9 0.1 0.0 0.1 0.0 1.0 0.3 0.1 ENOSF1 "FUCD, HSRTSBETA, rTS, TYMSAS" ENSG00000132199 "Enolase superfamily member 1" Q7L5Y1 18 670318-712662 "Enzymes, Predicted intracellular proteins" "Isomerase, Lyase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Proximal tubular cells: 216.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" HPA047829 Enhanced NA NA 7300 "Cluster 32: T-cells - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 15: RT4 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA047829: AB_2680170" "prognostic favorable (2.27e-4)" "unprognostic (8.03e-2)" "unprognostic (2.02e-2)" "unprognostic (7.87e-3)" "unprognostic (1.85e-1)" "unprognostic (4.29e-2)" "unprognostic (6.48e-3)" "unprognostic (1.55e-2)" "unprognostic (3.50e-3)" "unprognostic (1.33e-3)" "unprognostic (2.44e-2)" "unprognostic (5.07e-3)" "unprognostic (8.02e-2)" "unprognostic (1.72e-1)" "unprognostic (1.36e-1)" "unprognostic (5.03e-2)" "unprognostic (1.31e-2)" 8.4 25.0 3.1 3.2 4.4 7.7 9.3 3.3 7.2 10.0 5.5 12.0 5.5 6.6 2.1 12.0 10.6 3.2 11.0 2.9 4.2 28.0 29.3 8.1 2.8 3.8 3.4 8.6 15.8 5.0 11.3 4.0 3.7 13.3 3.9 5.9 14.9 2.5 5.0 7.5 11.0 2.3 3.2 9.5 14.6 5.3 4.0 3.2 18.6 1.6 1.9 9.0 8.1 5.3 3.5 9.6 6.0 5.8 1.6 2.1 5.2 4.9 5.4 1.0 3.6 10.6 10.5 3.8 1.8 0.8 4.1 4.1 8.0 3.7 2.2 2.6 4.4 7.2 12.0 5.4 6.9 11.8 3.2 3.2 8.5 1.7 5.7 1.7 5.7 10.5 6.2 9.6 2.0 8.8 13.8 7.3 2.6 13.1 5.0 4.7 2.2 12.7 5.3 14.0 7.6 3.1 7.7 8.4 2.7 2.2 3.2 14.2 2.9 2.8 5.4 5.5 2.6 14.0 15.2 8.1 12.8 8.3 2.6 0.0 0.5 1.4 3.5 1.6 2.7 0.8 2.3 1.9 0.8 0.5 3.3 3.4 0.1 1.2 0.6 2.4 1.7 0.9 3.1 4.4 3.3 7.2 2.9 4.2 3.8 3.4 3.7 3.2 4.0 5.3 17.9 35.3 99.5 36.9 10.1 11.9 29.5 29.6 24.5 35.2 38.4 36.4 19.6 28.6 44.7 47.8 116.7 44.6 25.6 36.7 115.4 32.4 7.0 61.6 32.2 19.6 24.7 73.2 4.2 14.4 27.7 26.5 61.2 40.1 22.2 26.2 23.9 56.6 39.1 0.0 7.6 36.0 38.7 12.6 8.8 6.8 23.6 20.9 19.6 30.0 12.1 30.9 24.7 38.2 143.6 21.9 36.2 28.2 25.2 25.9 50.9 216.9 78.3 98.8 13.1 38.7 15.8 14.7 29.3 39.8 12.1 37.8 22.0 67.8 49.4 20.8 ETNPPL AGXT2L1 ENSG00000164089 "Ethanolamine-phosphate phospho-lyase" Q8TBG4 4 108742048-108763054 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 155.6;liver: 191.1" "Cell type enriched" "Detected in some" 8 "Astrocytes: 219.4" "Group enriched" "Detected in some" 23 "glioma: 7.9;liver cancer: 21.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HeLa: 5.7;Hep G2: 2.3;NTERA-2: 1.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA044546, HPA072938" Supported Approved Nucleoplasm Yes NA "Cluster 15: Liver - Metabolism" "Cluster 20: HeLa - Mitochondria" "Cluster 64: Astrocytes - Nervous system maintenance" Nucleoplasm "HPA044546: AB_10962867, HPA072938: AB_2686560" "unprognostic (5.20e-3)" "unprognostic (1.33e-1)" "unprognostic (3.93e-1)" "prognostic favorable (9.52e-5)" "unprognostic (5.93e-3)" "unprognostic (3.91e-2)" "unprognostic (2.82e-1)" "unprognostic (6.32e-2)" "unprognostic (2.70e-2)" "unprognostic (1.30e-1)" "unprognostic (3.40e-2)" "unprognostic (1.93e-1)" "unprognostic (1.59e-1)" "unprognostic (1.42e-2)" "unprognostic (9.48e-2)" 0.3 5.5 155.6 0.1 155.6 0.0 0.1 98.4 144.3 0.1 47.4 0.0 0.2 0.3 0.0 0.1 0.0 0.2 10.6 124.4 145.8 9.1 191.1 0.1 0.0 100.7 118.1 0.1 0.0 2.9 1.9 0.0 110.3 0.0 0.0 1.7 34.4 0.1 2.4 0.0 0.0 0.0 101.2 0.7 18.3 0.5 119.8 0.1 1.1 1.5 0.0 0.0 0.0 101.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.5 0.0 5.7 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 1.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.2 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 155.6 155.6 98.4 144.3 124.4 145.8 100.7 118.1 110.3 101.2 119.8 101.3 0.0 0.0 0.0 219.4 0.2 0.0 0.0 0.0 0.0 0.0 1.2 0.0 14.2 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.2 0.4 0.0 0.0 0.4 0.0 0.0 0.5 1.5 0.4 0.0 0.0 0.7 26.8 0.0 0.0 0.6 0.0 0.0 1.6 0.0 1.7 0.0 0.0 0.0 7.5 0.0 8.5 0.0 1.5 0.7 0.0 0.0 0.0 0.1 0.0 0.0 7.9 0.0 0.2 0.0 0.2 0.2 0.2 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.1 FAHD1 "C16orf36, DKFZP566J2046" ENSG00000180185 "Fumarylacetoacetate hydrolase domain containing 1" Q6P587 16 1826941-1840207 "Enzymes, Predicted intracellular proteins" "Hydrolase, Lyase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "kidney: 64.1" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 112.2;Proximal tubular cells: 210.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025530, HPA043226, HPA043534" Enhanced Enhanced Nucleoplasm,Mitochondria NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria Nucleoplasm "CAB025530: , HPA043226: AB_2678370, HPA043534: AB_2678535" "unprognostic (3.71e-1)" "unprognostic (1.25e-2)" "prognostic favorable (8.27e-4)" "unprognostic (1.99e-1)" "unprognostic (6.74e-2)" "unprognostic (1.01e-3)" "unprognostic (2.89e-2)" "unprognostic (4.32e-1)" "unprognostic (1.13e-1)" "unprognostic (5.36e-2)" "unprognostic (1.65e-1)" "unprognostic (1.38e-1)" "prognostic favorable (2.80e-14)" "unprognostic (1.02e-1)" "unprognostic (1.66e-1)" "unprognostic (1.26e-1)" "unprognostic (3.31e-2)" 12.3 21.4 9.1 8.5 9.4 10.0 9.4 9.3 11.1 8.3 9.2 22.6 36.1 9.7 8.0 19.3 6.9 12.1 19.9 10.9 11.1 64.1 58.5 7.1 7.4 10.7 10.0 8.0 15.8 12.1 9.5 7.5 10.1 9.4 14.2 6.7 11.2 10.7 30.7 17.1 27.1 8.7 8.8 8.4 21.0 10.1 9.4 7.9 7.8 24.7 6.4 11.3 11.1 9.9 20.1 44.6 20.9 36.9 27.0 19.5 12.9 32.4 16.0 21.1 22.9 28.6 20.4 12.8 26.6 20.2 32.7 40.5 16.4 25.8 19.0 19.3 39.0 11.5 38.7 67.0 26.2 20.0 21.2 25.8 33.3 19.3 12.9 17.8 27.8 15.3 12.1 12.8 26.8 92.5 10.9 30.1 12.4 18.4 33.0 24.6 28.3 36.4 76.8 24.9 40.4 33.6 42.3 33.5 52.0 13.8 49.4 13.4 41.1 34.4 24.6 20.5 17.8 18.6 42.3 15.1 22.0 14.5 15.1 15.8 40.8 16.5 25.1 51.5 22.5 37.2 24.7 27.3 42.6 32.7 27.0 24.8 3.5 38.1 38.4 33.1 28.4 24.3 9.1 9.4 9.3 11.1 10.9 11.1 10.7 10.0 10.1 8.8 9.4 9.9 14.6 25.6 16.4 2.9 11.2 14.0 13.3 29.6 13.1 19.8 12.4 15.7 42.9 27.1 17.2 42.3 27.1 22.6 10.9 50.8 50.9 57.2 89.8 16.8 19.8 16.3 29.3 36.4 8.0 39.2 14.2 15.5 17.3 18.2 5.1 13.8 9.7 35.5 30.5 18.5 8.6 25.6 24.4 9.1 14.2 45.0 14.6 13.7 16.0 4.7 18.9 17.4 20.6 3.0 6.4 34.9 36.7 15.4 4.0 11.2 112.2 210.9 14.4 24.2 13.1 12.7 16.5 9.9 9.1 27.2 24.0 15.3 9.8 30.3 52.7 9.6 FASN "FAS, SDR27X1" ENSG00000169710 "Fatty acid synthase" P49327 17 82078338-82098294 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" "Hydrolase, Lyase, Multifunctional enzyme, Oxidoreductase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 372.8;breast: 271.6" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 126.0;Breast glandular cells: 442.9;Breast myoepithelial cells: 165.4;Hepatocytes: 244.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "SK-BR-3: 1109.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005192, HPA006461, CAB015417, HPA056108" Enhanced Enhanced "Plasma membrane,Cytosol" No No 3400000 "Cluster 57: Non-specific - Angiogenesis" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 30: Mammary glandular cells - Lactation" "Plasma membrane, Cytosol" "CAB005192: AB_2101095, CAB015417: AB_2231427, HPA006461: AB_1848437, HPA056108: AB_2683039" "unprognostic (3.35e-2)" "prognostic unfavorable (1.42e-5)" "unprognostic (9.69e-3)" "unprognostic (4.09e-2)" "unprognostic (3.46e-3)" "unprognostic (1.55e-2)" "unprognostic (3.09e-2)" "unprognostic (4.74e-3)" "unprognostic (3.15e-1)" "unprognostic (3.15e-1)" "unprognostic (2.87e-3)" "unprognostic (1.05e-1)" "prognostic unfavorable (7.16e-5)" "unprognostic (4.50e-2)" "unprognostic (9.62e-2)" "unprognostic (1.35e-2)" "unprognostic (7.03e-3)" 372.8 30.9 25.0 14.9 44.2 18.7 271.6 67.3 49.9 31.7 0.0 25.5 11.5 18.0 6.2 63.6 15.2 6.6 21.9 39.9 15.0 11.8 191.4 54.1 7.2 84.4 75.7 16.3 18.6 8.5 72.4 12.1 101.7 69.0 3.0 4.3 38.3 14.3 27.9 89.4 28.8 5.3 12.5 8.8 63.6 11.9 33.7 9.6 21.2 2.3 3.0 27.0 31.8 60.8 179.1 182.0 81.7 56.7 130.1 87.2 176.9 34.3 43.3 35.5 64.6 190.6 116.7 58.8 29.2 26.3 99.5 144.0 79.2 157.8 6.5 30.0 358.0 123.9 140.0 257.2 36.8 67.5 19.2 84.2 40.4 90.8 21.0 12.1 40.1 54.8 193.2 50.7 12.6 304.1 78.9 105.5 161.1 28.1 107.1 64.1 47.8 116.5 40.3 220.7 205.0 117.0 50.6 1109.2 93.6 29.5 199.4 123.4 71.1 52.3 107.0 45.2 88.4 68.5 17.1 60.6 31.2 71.1 79.5 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.2 0.2 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.1 25.0 44.2 67.3 49.9 39.9 15.0 84.4 75.7 101.7 12.5 33.7 60.8 9.6 25.6 126.0 28.4 7.4 7.8 12.7 33.2 8.0 28.7 442.9 165.4 5.9 21.5 28.4 11.0 6.2 32.0 12.8 35.7 3.9 19.2 1.5 19.6 19.8 10.8 18.1 20.6 11.9 29.2 77.7 13.4 33.6 17.1 12.7 29.9 10.8 244.1 13.9 30.3 12.5 22.3 22.4 9.8 6.2 3.4 16.4 7.0 17.8 4.7 6.2 14.1 8.2 11.6 17.6 19.1 23.6 11.3 9.7 60.4 6.5 5.9 23.7 13.1 0.0 9.0 14.9 1.8 11.7 34.1 13.8 29.6 10.6 27.9 27.4 19.6 FECH ENSG00000066926 Ferrochelatase P22830 18 57544377-57586702 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Heme biosynthesis, Porphyrin biosynthesis" Lyase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 6 "Distal tubular cells: 156.5;Erythroid cells: 479.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HMC-1: 32.7;K-562: 31.4;U-266/70: 33.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA044100, HPA048177" Approved NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 1: K-562 - Erythropoiesis" "Cluster 6: Erythroid cells - Oxygen transport" "HPA044100: AB_2678809, HPA048177: AB_2680300" "unprognostic (2.30e-1)" "unprognostic (3.17e-2)" "unprognostic (4.59e-3)" "unprognostic (6.85e-2)" "unprognostic (7.60e-2)" "unprognostic (1.08e-1)" "unprognostic (3.86e-2)" "unprognostic (3.34e-2)" "unprognostic (2.85e-2)" "unprognostic (2.43e-1)" "unprognostic (1.92e-1)" "unprognostic (2.36e-1)" "prognostic favorable (2.38e-10)" "unprognostic (1.10e-1)" "unprognostic (8.30e-2)" "unprognostic (4.05e-3)" "unprognostic (3.58e-2)" 9.3 14.7 5.2 1.9 6.3 39.6 8.8 4.7 6.3 7.8 5.8 10.0 1.8 9.2 2.9 12.0 7.6 2.6 17.0 4.8 5.2 20.9 22.0 6.5 1.9 6.3 5.3 8.4 9.2 4.3 8.9 3.2 7.2 9.5 2.4 3.6 9.0 2.4 32.2 8.4 7.2 2.8 5.3 10.0 8.4 4.7 5.3 5.0 9.7 7.4 1.8 9.9 8.5 9.7 5.3 15.1 4.3 8.2 2.6 7.4 4.2 4.5 3.4 2.9 4.0 7.3 3.0 4.8 4.3 6.8 3.9 3.5 4.2 3.8 3.7 6.6 19.0 29.5 12.8 10.5 4.9 17.7 32.7 5.4 4.0 4.0 1.4 4.2 5.3 8.0 31.4 10.9 2.1 10.1 7.8 3.8 4.3 1.9 8.7 6.3 19.7 4.7 8.6 19.1 2.5 8.4 4.8 7.4 3.4 2.5 4.6 2.8 6.8 3.3 1.9 1.4 3.2 33.4 12.4 6.3 3.5 5.6 3.9 3.7 3.8 8.1 4.5 5.0 3.2 2.4 3.0 4.9 6.6 1.0 2.8 3.3 0.6 6.9 5.2 4.3 3.2 3.8 5.2 6.3 4.7 6.3 4.8 5.2 6.3 5.3 7.2 5.3 5.3 9.7 4.9 6.4 10.6 10.4 5.6 2.5 6.7 8.6 5.2 3.8 7.8 6.1 24.5 15.7 7.2 5.5 4.2 36.6 15.4 6.7 156.5 16.4 0.4 6.6 7.9 7.3 2.4 479.7 20.3 16.3 16.5 10.3 4.6 9.7 16.5 11.8 4.2 26.3 33.4 8.4 14.6 4.1 8.2 10.6 4.9 1.1 9.9 12.7 1.8 12.2 15.4 15.1 9.2 12.1 45.5 12.4 6.4 7.2 12.5 6.5 7.0 18.2 9.8 4.1 0.0 9.0 6.8 4.1 5.5 14.2 3.1 24.2 8.1 19.1 5.7 5.0 FH ENSG00000091483 "Fumarate hydratase" P07954 1 241497603-241519755 "Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Tricarboxylic acid cycle" Lyase "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 276.4" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 173.5;Early spermatids: 226.0;Syncytiotrophoblasts: 166.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017785, HPA025770, HPA025948, HPA027341" Enhanced Supported Enhanced Mitochondria NA NA 1800000 "Cluster 44: Non-specific - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 25: RPMI-8226 - Immune response" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "CAB017785: , HPA025770: AB_10599603, HPA025948: AB_10602177, HPA027341: AB_10601222" "unprognostic (1.03e-2)" "unprognostic (3.82e-2)" "unprognostic (9.46e-3)" "unprognostic (2.18e-1)" "unprognostic (2.10e-1)" "unprognostic (2.07e-1)" "unprognostic (2.28e-2)" "unprognostic (1.55e-1)" "unprognostic (5.14e-2)" "unprognostic (1.85e-2)" "unprognostic (1.27e-2)" "unprognostic (1.09e-1)" "prognostic favorable (2.76e-7)" "unprognostic (1.05e-1)" "unprognostic (1.05e-1)" "unprognostic (4.41e-2)" "unprognostic (1.24e-2)" 43.4 75.2 30.4 31.0 33.3 31.4 37.3 33.5 42.0 28.9 43.9 66.8 68.2 36.9 26.1 51.1 27.9 23.7 179.0 33.9 33.1 101.8 276.4 26.4 30.0 31.8 31.0 24.9 38.1 95.0 31.1 32.1 32.1 33.5 69.0 58.8 42.0 38.4 213.4 40.3 59.1 42.0 32.4 30.1 53.6 44.4 32.7 31.3 34.6 229.3 40.4 37.5 33.7 33.0 129.2 105.6 97.9 89.0 93.9 110.0 154.9 155.7 121.1 171.6 107.1 152.2 78.0 81.1 100.3 119.9 75.0 178.4 151.7 115.8 148.4 93.5 48.9 76.3 102.2 131.4 84.1 180.2 66.7 80.2 70.7 96.6 108.0 60.2 107.2 175.8 236.3 101.7 126.9 64.3 156.6 120.1 104.5 186.2 223.6 127.4 107.2 365.7 167.4 107.6 125.4 108.4 131.1 153.3 104.0 67.2 117.1 120.9 106.5 76.6 98.9 137.0 264.0 90.3 103.7 97.3 85.7 203.5 112.6 11.9 22.8 4.9 16.1 33.3 21.0 27.2 18.8 15.1 46.7 25.1 22.3 21.1 1.3 18.3 29.1 23.1 23.8 16.7 30.4 33.3 33.5 42.0 33.9 33.1 31.8 31.0 32.1 32.4 32.7 33.0 17.1 38.5 30.2 9.4 25.0 20.0 24.6 69.5 17.1 24.7 19.9 17.5 173.5 35.8 40.0 23.9 14.6 101.6 13.7 44.0 78.2 60.4 226.0 25.4 23.5 18.6 18.0 37.7 12.7 45.0 58.7 25.5 26.5 25.4 19.0 24.9 13.6 80.4 50.7 35.3 14.9 40.6 48.8 18.5 14.4 37.4 23.9 23.9 24.9 8.4 27.9 35.0 10.3 8.0 14.4 29.4 35.7 26.7 41.3 19.0 66.1 86.0 29.2 39.1 39.5 27.7 67.9 84.7 47.1 32.1 18.6 166.1 14.9 48.4 74.2 22.8 FTCD ENSG00000160282 "Formimidoyltransferase cyclodeaminase" O95954 21 46136262-46155579 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Histidine metabolism" "Lyase, Multifunctional enzyme, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "liver: 939.8" "Cell type enhanced" "Detected in many" "Cholangiocytes: 131.5;Early spermatids: 104.7;Hepatocytes: 444.9;Late spermatids: 124.3;Proximal tubular cells: 395.1" "Cancer enriched" "Detected in some" 8 "liver cancer: 87.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 30 "Hep G2: 92.9" "Not detected" "Not detected" "Not detected" "Not detected" "HPA020073, HPA030928, HPA030929, HPA036114" Enhanced Approved "Plasma membrane,Cytosol" No NA 1600000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Cytosol "Plasma membrane" "HPA020073: AB_1849005, HPA030928: AB_2673664, HPA030929: AB_2673665, HPA036114: AB_2674947" "unprognostic (1.71e-1)" "unprognostic (2.27e-1)" "unprognostic (4.62e-5)" "unprognostic (2.90e-2)" "unprognostic (1.13e-1)" "unprognostic (2.96e-1)" "prognostic favorable (1.70e-4)" "unprognostic (1.85e-1)" "unprognostic (2.67e-1)" "unprognostic (1.99e-1)" "prognostic favorable (6.78e-5)" "unprognostic (1.80e-1)" "prognostic favorable (5.78e-4)" "unprognostic (3.80e-2)" "unprognostic (3.60e-1)" "unprognostic (9.37e-2)" "unprognostic (2.10e-1)" 0.4 1.7 5.4 0.2 6.8 0.0 0.4 3.6 8.4 1.3 3.0 1.3 1.3 1.2 0.4 0.3 0.9 0.1 1.6 4.9 4.7 155.7 939.8 0.2 0.2 4.6 3.9 3.0 4.0 0.0 3.4 0.0 5.6 4.2 0.0 0.0 0.2 0.6 0.4 0.3 1.7 0.0 3.5 0.5 0.5 13.9 4.4 0.0 0.9 0.0 0.0 1.3 1.0 5.5 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.1 0.0 3.1 0.0 0.3 0.2 0.0 0.7 0.0 0.0 0.0 0.0 0.1 0.6 0.6 0.0 92.9 0.0 0.6 0.3 0.1 0.0 0.2 0.0 0.0 0.0 0.2 0.7 0.0 0.0 0.7 0.0 0.0 1.9 0.0 0.1 0.2 0.2 0.0 0.2 0.0 0.9 0.3 0.0 0.1 0.1 0.1 0.1 0.0 0.0 0.3 0.4 0.5 0.0 0.3 0.1 0.0 0.4 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 5.4 6.8 3.6 8.4 4.9 4.7 4.6 3.9 5.6 3.5 4.4 5.5 0.0 0.0 0.0 1.0 8.1 0.1 0.0 0.0 0.0 1.3 0.2 0.5 1.5 131.5 0.0 9.2 0.0 0.0 0.1 0.0 46.9 0.0 104.7 0.1 0.4 1.8 0.0 61.5 10.5 0.0 0.0 0.6 0.0 0.2 0.0 0.6 30.4 444.9 0.1 3.3 5.9 0.1 0.0 28.9 0.0 124.3 3.1 1.6 0.0 1.0 0.0 0.2 0.0 1.0 18.5 0.0 0.1 2.6 0.0 0.5 0.3 395.1 0.0 0.4 0.0 0.2 0.5 39.2 17.9 0.2 0.4 0.0 3.6 0.1 0.2 0.1 GAD1 GAD ENSG00000128683 "Glutamate decarboxylase 1" Q99259 2 170813213-170861151 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Neurotransmitter biosynthesis" "Decarboxylase, Lyase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 12 "brain: 98.5;parathyroid gland: 46.3;retina: 29.7" "Group enriched" "Detected in many" 8 "Inhibitory neurons: 392.8;Oligodendrocyte precursor cells: 146.8" "Cancer enhanced" "Detected in many" "endometrial cancer: 4.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HaCaT: 20.1;HEL: 64.5" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "olfactory bulb: 547.6" "CAB004415, HPA048871, HPA058412, CAB078176" Enhanced Supported Approved "Vesicles,Plasma membrane,Cytosol" NA NA "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 36: HEL - Hemostasis" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Vesicles, Plasma membrane, Cytosol" "CAB004415: AB_627650, CAB078176: AB_2665792, HPA048871: , HPA058412: AB_2683710" "unprognostic (1.28e-1)" "prognostic favorable (7.31e-4)" "unprognostic (1.87e-2)" "prognostic favorable (8.61e-4)" "unprognostic (1.12e-1)" "unprognostic (3.05e-1)" "unprognostic (4.97e-7)" "unprognostic (1.51e-1)" "unprognostic (7.72e-2)" "unprognostic (4.27e-4)" "unprognostic (6.75e-2)" "unprognostic (9.18e-3)" "unprognostic (6.90e-5)" "unprognostic (2.93e-2)" "unprognostic (6.57e-2)" "unprognostic (1.56e-2)" "unprognostic (3.08e-3)" 0.2 3.0 22.1 0.0 29.9 3.3 0.1 15.5 33.0 1.0 0.0 0.0 0.0 1.6 4.3 0.4 0.2 0.1 0.0 17.1 98.5 4.8 0.1 0.2 0.1 12.4 41.6 0.2 0.2 46.3 5.0 0.4 17.6 0.8 0.1 29.7 0.1 0.3 0.0 0.2 0.1 0.0 12.7 0.1 0.0 3.2 31.1 0.8 0.1 0.0 0.2 0.6 0.4 14.2 18.2 0.7 0.0 7.3 0.0 0.0 0.1 0.4 0.0 2.6 1.7 4.6 6.7 0.0 0.9 0.5 2.9 20.1 2.3 0.6 1.6 2.8 13.4 64.5 6.0 0.2 0.0 0.3 1.1 0.0 5.5 0.0 2.3 0.6 0.1 0.5 17.0 0.3 0.8 1.5 0.0 0.0 8.1 9.7 6.7 1.0 4.6 0.4 8.5 9.4 6.7 2.1 12.6 0.0 3.5 0.6 0.2 0.0 0.0 12.0 1.7 2.4 7.0 0.0 0.0 0.1 11.5 3.2 16.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 22.1 29.9 15.5 33.0 17.1 98.5 12.4 41.6 17.6 12.7 31.1 14.2 0.0 0.0 0.0 14.7 0.0 0.3 2.1 7.7 2.2 32.5 0.1 0.1 1.3 0.0 3.6 0.0 10.4 0.0 0.0 0.2 7.9 4.5 5.6 4.4 0.4 0.4 3.0 5.5 2.6 5.6 0.1 0.2 0.0 2.9 0.0 5.5 0.0 0.0 4.0 5.0 392.8 0.3 2.0 0.8 0.4 6.2 0.6 0.5 0.0 7.5 0.0 4.9 0.0 146.8 7.6 2.9 0.0 0.0 0.1 0.9 0.0 0.0 4.7 6.0 0.0 0.0 1.2 4.4 7.7 0.6 0.1 0.5 0.0 0.1 0.1 0.4 GAD2 GAD65 ENSG00000136750 "Glutamate decarboxylase 2" Q05329 10 26216665-26304558 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Neurotransmitter biosynthesis" "Decarboxylase, Lyase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 7 "brain: 37.6;retina: 9.5" "Cell type enriched" "Detected in some" 13 "Inhibitory neurons: 293.9" "Cancer enhanced" "Detected in some" "pancreatic cancer: 3.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 6 "SCLC-21H: 2.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA044637, CAB078177" Enhanced NA NA "Cluster 65: Brain - Ion transport" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB078177: AB_2665779, HPA044637: AB_10794053" "unprognostic (8.67e-2)" "unprognostic (1.11e-1)" "unprognostic (4.93e-2)" "unprognostic (2.52e-5)" "unprognostic (5.44e-2)" "unprognostic (8.08e-2)" 0.0 0.0 13.1 0.0 37.3 0.0 0.0 6.9 16.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 6.0 37.6 0.0 0.0 0.0 0.0 6.6 14.8 0.0 3.6 0.0 0.4 0.0 7.7 0.0 0.0 9.5 0.0 0.0 0.0 0.1 0.0 0.0 3.1 0.0 0.1 0.4 11.9 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.1 37.3 6.9 16.2 6.0 37.6 6.6 14.8 7.7 3.1 11.9 3.6 0.0 0.0 0.0 6.2 0.0 0.0 0.0 0.0 0.0 7.7 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.2 0.0 0.0 0.0 1.8 0.0 1.6 0.7 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 293.9 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 5.6 0.0 0.3 0.0 2.0 6.1 21.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.3 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GADL1 ENSG00000144644 "Glutamate decarboxylase like 1" Q6ZQY3 3 30726200-30894765 "Enzymes, Predicted intracellular proteins" "Decarboxylase, Lyase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 7 "skeletal muscle: 25.8;tongue: 11.3" "Cell type enhanced" "Detected in some" "Bipolar cells: 1.4;Club cells: 1.3;Collecting duct cells: 1.8;Fibroblasts: 5.9;Late spermatids: 1.8;Skeletal myocytes: 1.6" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HAP1: 4.7;TIME: 2.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA039160, HPA040229" Uncertain Approved "Plasma membrane,Cytosol" NA NA "Cluster 33: Striated muscle - Muscle contraction" "Cluster 2: Karpas-707 - Immune response" "Cluster 37: Myocytes - Muscle contraction" "Plasma membrane, Cytosol" "HPA039160: AB_10796222, HPA040229: AB_10796118" "unprognostic (4.96e-2)" "unprognostic (1.30e-2)" "unprognostic (9.83e-2)" "unprognostic (1.39e-2)" "unprognostic (5.60e-2)" "unprognostic (7.32e-2)" "unprognostic (5.05e-3)" "unprognostic (8.37e-2)" "unprognostic (1.23e-2)" "unprognostic (2.02e-3)" "unprognostic (1.63e-1)" "unprognostic (1.98e-5)" "unprognostic (8.81e-2)" "unprognostic (4.54e-2)" "unprognostic (4.39e-1)" "unprognostic (1.06e-1)" 0.3 0.4 2.2 0.4 2.1 1.2 0.4 2.6 2.5 0.1 0.1 0.2 0.2 0.3 0.6 0.6 0.2 0.3 0.6 1.8 0.8 0.7 0.3 0.3 0.4 0.9 0.5 0.6 0.4 0.2 0.2 0.3 0.9 0.6 0.2 1.7 0.4 0.1 25.8 0.9 0.2 0.2 0.1 0.6 0.3 0.5 1.0 0.1 0.9 11.3 0.3 0.2 0.0 2.3 0.4 0.0 0.2 0.4 0.3 0.1 0.5 0.2 0.1 0.0 0.0 0.5 0.5 0.4 0.2 0.0 0.2 0.3 4.7 0.1 0.1 0.6 0.1 0.5 0.8 0.2 0.0 0.3 1.3 0.1 0.1 0.2 0.1 0.4 0.1 0.3 0.5 1.7 0.2 0.3 0.2 0.5 0.5 0.1 0.1 0.7 0.9 0.4 0.2 0.6 0.5 0.3 0.2 0.3 1.3 0.3 0.4 0.3 2.4 0.6 0.5 0.8 0.2 0.6 0.3 0.3 0.2 0.2 0.6 0.2 0.1 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.1 0.2 0.0 0.1 0.0 0.1 0.0 2.2 2.1 2.6 2.5 1.8 0.8 0.9 0.5 0.9 0.1 1.0 2.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.6 0.0 1.3 1.8 0.0 0.1 0.0 0.0 0.0 0.0 0.7 0.0 0.1 0.3 0.0 0.0 0.5 0.0 0.0 5.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.3 1.8 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 1.6 0.2 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 GGACT A2LD1 ENSG00000134864 "Gamma-glutamylamine cyclotransferase" Q9BVM4 13 100530164-100589528 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 5 "kidney: 75.5" "Cell type enriched" "Detected in many" 6 "Proximal tubular cells: 152.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in many" 5 "SCLC-21H: 133.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA065320 Enhanced NA NA 110000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 7: Kidney - Transmembrane transport" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA065320: AB_2685466" "unprognostic (1.93e-1)" "unprognostic (5.33e-2)" "unprognostic (2.32e-1)" "unprognostic (1.30e-3)" "unprognostic (9.12e-3)" "unprognostic (1.64e-2)" "unprognostic (1.58e-2)" "unprognostic (2.07e-2)" "unprognostic (7.41e-2)" "unprognostic (2.81e-1)" "unprognostic (3.03e-2)" "unprognostic (2.45e-1)" "unprognostic (1.95e-2)" "unprognostic (3.09e-2)" "unprognostic (1.07e-1)" "unprognostic (3.37e-2)" "unprognostic (2.57e-1)" 5.8 6.0 3.4 3.8 4.1 1.6 5.0 3.9 4.7 2.6 3.5 7.6 8.7 3.2 2.1 2.7 3.0 2.9 1.6 3.1 4.0 75.5 16.7 3.0 3.4 4.4 4.1 2.8 15.2 3.0 1.5 3.0 3.9 3.4 4.9 6.8 8.9 3.1 2.3 4.8 6.1 2.4 4.3 4.1 7.1 6.6 3.8 3.6 3.5 4.2 5.8 3.4 2.5 4.7 14.2 1.7 11.3 12.2 9.4 14.3 4.9 8.8 2.3 1.5 3.8 0.2 12.6 1.4 4.9 6.4 0.2 0.7 1.8 2.6 0.5 20.1 7.6 6.0 1.1 0.7 13.4 8.6 19.1 17.3 9.8 0.2 0.8 0.1 5.7 6.6 3.1 0.3 2.3 0.9 1.4 1.1 0.6 27.4 3.8 0.9 2.8 1.8 14.1 2.4 133.3 5.0 2.8 6.2 6.6 10.5 5.9 28.0 5.5 0.0 0.1 3.0 2.4 7.3 4.4 0.5 0.7 6.4 6.2 0.0 4.1 0.8 5.8 5.9 5.5 3.9 4.8 6.4 3.3 4.3 2.9 4.3 0.0 7.0 6.2 2.4 5.4 3.4 3.4 4.1 3.9 4.7 3.1 4.0 4.4 4.1 3.9 4.3 3.8 4.7 3.2 0.0 1.5 7.5 7.2 2.7 3.0 1.1 5.2 1.7 4.4 3.2 0.9 1.5 2.1 7.3 14.6 13.4 2.6 4.6 7.9 8.7 4.7 2.6 2.1 3.4 7.8 1.7 2.7 10.0 11.8 3.6 3.1 4.2 5.7 4.1 4.2 14.0 12.1 1.7 3.2 4.7 2.0 9.8 1.4 10.3 2.8 6.2 0.0 4.7 10.0 6.8 19.6 3.5 8.0 9.1 4.5 3.8 2.1 2.3 10.5 152.0 0.1 3.3 6.6 4.3 1.8 22.5 10.9 3.9 2.0 4.4 6.1 12.4 7.7 2.5 GGCT "C7orf24, CRF21, GCTG, Ggc, MGC3077" ENSG00000006625 Gamma-glutamylcyclotransferase O75223 7 30496621-30504841 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 414.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020735, HPA029914" Approved NA Yes 2100000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 30: Epididymis - Antimicrobial activity" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 47: Cytotrophoblasts - Unknown function" "HPA020735: AB_1845754, HPA029914: AB_10602321" "prognostic unfavorable (7.68e-4)" "unprognostic (2.66e-1)" "unprognostic (2.51e-2)" "unprognostic (2.62e-1)" "unprognostic (2.54e-3)" "unprognostic (5.80e-2)" "prognostic unfavorable (7.23e-4)" "unprognostic (1.33e-3)" "unprognostic (2.19e-2)" "unprognostic (6.42e-3)" "unprognostic (2.66e-3)" "unprognostic (1.68e-1)" "unprognostic (2.27e-2)" "unprognostic (1.19e-1)" "unprognostic (8.12e-3)" "unprognostic (2.00e-3)" "unprognostic (9.92e-2)" 58.6 25.6 18.1 28.4 20.5 22.4 44.8 16.9 24.4 19.2 19.5 38.6 31.3 17.3 105.2 51.7 24.4 25.9 13.0 20.0 18.3 31.9 35.6 16.6 27.8 18.0 18.1 15.5 23.3 43.5 15.9 34.8 17.3 24.9 39.4 10.7 33.4 15.9 16.9 56.5 26.6 21.2 17.3 16.0 22.7 12.1 19.7 21.9 19.3 20.8 32.2 33.1 31.2 17.8 194.0 50.0 79.4 107.7 32.6 58.8 92.5 64.6 25.1 60.5 72.4 66.6 66.1 123.7 42.0 24.3 68.9 238.8 84.1 67.8 78.6 24.0 93.1 87.7 104.6 88.6 42.6 150.1 65.4 57.6 53.4 63.4 81.0 20.9 62.1 58.7 126.8 69.4 48.6 108.6 91.4 202.1 115.6 198.3 79.5 90.1 91.9 123.8 59.5 174.0 100.3 101.2 58.0 355.9 73.5 102.8 228.7 140.7 37.7 39.6 75.6 75.6 128.6 50.8 129.2 96.7 30.9 201.4 75.9 10.4 19.9 7.0 14.1 20.4 19.9 22.7 18.8 18.4 34.2 17.2 17.8 17.4 1.1 25.0 12.2 30.0 26.1 17.2 18.1 20.5 16.9 24.4 20.0 18.3 18.0 18.1 17.3 17.3 19.7 17.8 37.9 16.0 39.4 10.1 25.1 77.0 50.1 96.0 60.3 23.4 107.0 109.5 51.6 24.3 67.0 44.1 4.2 414.7 21.8 56.9 123.3 99.8 29.2 129.6 40.4 46.3 28.3 53.0 26.0 80.1 167.7 41.4 44.9 103.8 27.3 53.5 33.5 51.4 129.8 33.7 10.1 90.1 67.1 44.5 57.4 10.0 24.8 42.8 62.2 12.2 36.2 32.2 24.7 8.5 8.9 60.1 50.6 39.1 33.4 68.8 60.6 188.4 69.4 15.1 26.3 25.2 45.1 63.3 46.7 147.0 74.7 135.6 26.7 67.7 138.0 69.6 GGCX VKCFD1 ENSG00000115486 "Gamma-glutamyl carboxylase" P38435 2 85544720-85561547 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins" Lyase "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 5 "liver: 118.8" "Cell type enhanced" "Detected in all" "Hepatocytes: 163.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA018284 Enhanced NA NA "Cluster 10: Basophils - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 24: Non-specific - Transcription regulation" "HPA018284: AB_1849641" "unprognostic (4.88e-3)" "unprognostic (1.13e-2)" "unprognostic (1.22e-2)" "prognostic unfavorable (1.82e-6)" "unprognostic (5.67e-2)" "unprognostic (1.85e-3)" "unprognostic (2.96e-2)" "unprognostic (3.77e-2)" "unprognostic (5.64e-2)" "unprognostic (2.18e-2)" "unprognostic (6.45e-3)" "unprognostic (5.23e-2)" "unprognostic (8.17e-3)" "unprognostic (7.85e-2)" "unprognostic (2.59e-1)" "unprognostic (7.63e-3)" "unprognostic (9.38e-2)" 13.8 11.0 6.0 8.3 7.4 3.2 10.8 8.3 7.7 10.7 11.7 7.8 7.4 10.5 13.8 9.2 10.5 11.3 9.5 6.9 6.2 16.3 118.8 13.8 6.3 7.4 6.9 12.4 15.8 18.0 7.8 23.4 7.5 10.0 9.9 7.7 14.7 12.1 7.9 9.2 7.3 13.4 7.3 6.2 9.1 4.7 7.0 4.8 12.6 8.6 7.2 12.2 8.8 11.2 17.1 27.2 19.0 21.3 93.8 26.6 42.2 29.9 35.1 21.6 30.4 47.3 20.6 6.1 29.7 49.3 27.1 27.2 13.7 37.7 23.7 10.9 18.7 11.1 17.4 45.2 34.8 7.0 10.1 33.1 22.0 43.8 29.7 35.6 31.0 10.8 13.5 8.7 63.5 22.4 3.5 5.3 8.9 47.7 23.4 6.6 44.6 15.3 30.0 32.5 7.2 12.1 26.8 52.2 28.2 32.1 25.6 6.8 28.6 27.5 23.9 27.1 20.9 6.8 20.1 5.1 26.5 7.1 39.4 3.7 4.2 2.2 1.7 4.4 1.6 0.4 0.7 0.7 2.9 0.4 1.7 1.6 1.7 1.4 2.6 2.4 1.2 2.0 6.0 7.4 8.3 7.7 6.9 6.2 7.4 6.9 7.5 7.3 7.0 11.2 27.1 28.9 40.3 10.1 25.1 18.7 20.6 27.8 13.6 21.6 22.9 19.8 27.9 32.9 24.1 29.5 16.7 60.8 28.4 16.1 7.9 29.9 4.2 16.9 19.4 20.8 14.4 5.7 10.9 39.5 50.2 29.4 11.7 26.8 15.8 17.8 23.9 163.0 31.3 8.4 8.9 17.6 22.4 26.9 29.0 2.2 20.2 24.5 21.4 5.6 29.6 19.5 17.5 9.5 12.6 25.0 12.6 20.3 38.4 16.4 16.2 27.1 16.9 33.6 6.6 42.3 22.8 23.5 11.2 20.0 15.2 53.8 20.8 15.1 16.4 23.6 GLO1 GLOD1 ENSG00000124767 "Glyoxalase I" Q04760 6 38675925-38703145 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Lyase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 4 "HMC-1: 2571.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB040541, CAB040542, HPA059791" Enhanced Supported "Nucleoplasm,Plasma membrane,Cytosol" No No 1500000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 3: HMC-1 - Innate immune response" "Cluster 38: Extravillous trophoblasts - Unknown function" "Nucleoplasm, Plasma membrane, Cytosol" "CAB040541: , CAB040542: , HPA059791: AB_2684126" "unprognostic (4.33e-2)" "unprognostic (1.09e-1)" "unprognostic (4.37e-2)" "unprognostic (1.08e-2)" "unprognostic (3.96e-3)" "unprognostic (2.51e-1)" "prognostic unfavorable (5.21e-4)" "unprognostic (5.09e-2)" "unprognostic (2.10e-2)" "unprognostic (1.28e-2)" "unprognostic (2.61e-2)" "unprognostic (8.71e-2)" "unprognostic (1.20e-2)" "unprognostic (9.29e-2)" "unprognostic (1.83e-1)" "unprognostic (2.54e-1)" "unprognostic (6.21e-2)" 55.4 62.3 69.4 38.9 74.1 31.6 74.2 74.6 83.4 55.9 77.2 51.8 116.3 57.8 110.9 60.0 72.3 41.4 88.9 72.6 76.2 87.2 157.7 66.6 48.4 73.7 72.8 82.8 42.1 106.1 23.2 64.1 75.1 171.4 52.3 100.3 43.2 62.1 154.2 66.6 67.7 61.8 77.9 48.2 48.5 27.9 72.9 50.0 54.8 128.8 60.3 52.4 51.6 77.1 201.6 92.0 257.4 256.7 119.2 213.9 227.0 171.1 161.4 235.4 243.0 224.4 75.3 222.5 132.2 137.5 280.1 129.5 222.5 221.1 295.8 203.8 343.0 329.4 105.7 211.3 178.5 126.7 2571.5 183.9 133.5 223.7 159.0 153.2 258.5 154.9 264.7 143.6 223.3 170.6 199.5 160.5 185.5 179.2 176.7 171.0 311.1 145.8 217.8 149.9 199.3 201.3 120.6 165.4 329.8 175.9 192.4 628.3 107.6 182.0 167.1 159.8 275.9 112.7 227.0 608.6 66.1 322.7 299.6 23.7 20.7 15.3 35.5 33.4 48.0 51.9 35.3 36.7 39.0 51.4 32.7 34.9 2.7 23.5 26.9 60.4 34.1 33.3 69.4 74.1 74.6 83.4 72.6 76.2 73.7 72.8 75.1 77.9 72.9 77.1 69.2 131.4 174.4 26.1 86.3 64.6 112.6 88.2 37.0 56.1 67.7 55.8 133.2 58.6 84.5 90.1 20.9 102.7 68.3 34.1 248.4 132.1 4.5 76.2 58.8 74.3 36.5 83.5 23.9 73.3 323.0 86.0 53.0 67.5 71.4 78.7 161.0 114.0 78.8 69.0 21.9 39.3 99.7 125.7 72.8 6.5 83.9 70.0 104.9 17.8 92.6 190.3 49.4 25.1 24.8 77.3 36.0 109.9 86.4 178.8 103.2 132.2 80.7 65.5 46.0 62.0 70.9 15.0 16.1 77.2 88.2 73.2 62.4 123.7 63.4 130.2 GMDS "GMD, SDR3E1" ENSG00000112699 "GDP-mannose 4,6-dehydratase" O60547 6 1623806-2245605 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 106.0;salivary gland: 105.4;stomach 1: 97.1" "Cell type enhanced" "Detected in many" "Excitatory neurons: 208.5;Gastric mucus-secreting cells: 276.8;Intestinal goblet cells: 367.6;Proximal enterocytes: 190.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "OE19: 246.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031528 Enhanced NA NA 72000 "Cluster 39: Non-specific - mRNA processing" "Cluster 37: Intestine - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 27: Mucus-secreting cells - Mucin production" "HPA031528: AB_10601016" "unprognostic (5.94e-2)" "unprognostic (3.92e-2)" "unprognostic (1.12e-1)" "prognostic favorable (5.89e-4)" "unprognostic (4.37e-1)" "unprognostic (1.53e-1)" "unprognostic (1.10e-3)" "unprognostic (7.15e-2)" "unprognostic (2.29e-1)" "unprognostic (8.02e-2)" "unprognostic (2.38e-1)" "unprognostic (4.41e-1)" "prognostic favorable (5.93e-4)" "unprognostic (2.45e-1)" "unprognostic (2.84e-1)" "unprognostic (6.68e-2)" "unprognostic (1.12e-1)" 10.7 7.6 8.6 30.1 7.1 9.1 14.6 5.8 7.1 29.4 9.7 87.7 106.0 7.8 10.4 65.8 11.5 20.5 9.5 7.6 7.0 19.6 31.1 9.0 14.2 6.6 6.9 6.7 43.8 20.5 12.9 7.1 6.7 18.3 82.4 1.5 105.4 8.0 5.1 10.6 87.3 10.3 6.1 11.4 97.1 9.2 7.3 13.9 11.9 4.9 20.8 13.7 14.2 6.2 45.9 10.6 7.4 52.6 11.8 32.0 17.9 12.5 25.7 22.7 21.2 23.1 26.1 21.7 37.3 13.6 22.4 18.3 22.9 43.8 26.2 30.0 28.8 21.0 11.2 110.3 13.2 34.2 22.5 35.6 14.9 18.0 37.2 21.9 26.9 73.0 13.9 9.8 14.7 26.3 49.0 40.1 11.4 246.4 36.0 24.8 16.8 112.4 55.4 59.5 41.4 9.9 11.5 17.7 28.8 33.6 16.4 21.4 11.7 17.4 13.1 17.7 22.5 22.1 33.6 23.1 11.4 23.6 23.4 7.0 12.9 1.5 7.8 8.3 10.3 10.5 9.4 7.5 14.5 5.0 7.6 10.8 3.8 13.1 6.8 6.1 13.2 8.3 8.6 7.1 5.8 7.1 7.6 7.0 6.6 6.9 6.7 6.1 7.3 6.2 19.7 0.0 4.5 40.8 19.8 4.2 20.1 38.3 27.3 3.7 33.1 19.3 2.9 12.8 40.5 38.6 0.0 18.7 6.5 104.1 119.3 36.5 5.7 7.8 7.3 23.0 111.7 9.7 208.5 69.7 30.8 12.4 276.8 11.9 4.5 13.2 18.2 19.6 13.5 8.4 167.5 367.6 50.8 10.9 7.6 4.6 12.2 11.0 23.2 143.4 14.7 3.3 9.2 83.9 50.2 47.0 85.5 16.6 53.1 40.7 190.7 38.1 38.3 0.7 13.1 5.8 16.6 6.5 33.1 20.1 6.1 16.7 18.6 13.4 165.1 43.5 GSTM4 ENSG00000168765 "Glutathione S-transferase mu 4" Q03013 1 109656099-109674836 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lipid metabolism" "Lyase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 149.5" "Cell type enhanced" "Detected in many" "Proximal enterocytes: 382.8;Proximal tubular cells: 109.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 9 "eosinophil: 351.7" "Lineage enriched" "Detected in all" 9 "granulocytes: 351.7" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA048652, HPA055972, HPA055973" Approved Approved "Cytokinetic bridge,Cytosol" Yes NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 45: Enterocytes - Digestion" Cytosol "Cytokinetic bridge" "HPA048652: AB_2680478, HPA055972: AB_2682992, HPA055973: AB_2682993" "prognostic favorable (9.96e-5)" "unprognostic (1.96e-3)" "unprognostic (7.49e-2)" "unprognostic (9.92e-3)" "unprognostic (1.48e-1)" "unprognostic (1.08e-2)" "unprognostic (8.47e-2)" "unprognostic (3.48e-2)" "unprognostic (1.20e-1)" "unprognostic (4.76e-2)" "unprognostic (3.73e-1)" "unprognostic (1.44e-1)" "unprognostic (1.46e-1)" "unprognostic (1.92e-2)" "unprognostic (2.20e-1)" "unprognostic (1.41e-1)" "unprognostic (2.47e-2)" 22.3 31.1 19.7 15.3 23.7 5.9 22.5 19.1 23.8 24.5 40.0 45.4 149.5 22.6 24.3 31.3 22.2 17.8 33.5 19.2 19.9 45.9 41.2 14.6 11.8 20.7 20.9 42.9 21.2 57.8 18.6 7.6 20.2 25.8 38.5 12.5 21.2 41.0 92.4 20.6 99.4 25.7 21.1 30.2 28.8 15.1 20.1 9.9 27.7 45.5 15.6 36.8 28.8 20.2 13.5 6.0 10.5 78.9 23.0 35.1 13.4 4.3 34.1 9.8 12.8 43.3 1.5 12.5 16.1 19.1 19.3 13.6 27.1 14.4 6.2 18.9 0.0 27.4 23.5 38.8 37.1 9.5 31.8 22.3 14.0 12.6 0.0 27.5 8.1 31.7 12.8 18.4 6.9 12.7 8.1 41.9 8.2 56.3 31.9 16.9 5.8 18.5 38.8 9.6 7.4 17.6 0.2 68.2 54.9 7.8 18.6 20.1 3.6 11.4 44.0 12.5 6.3 27.0 51.4 1.1 37.1 13.9 32.5 11.9 14.5 351.7 12.2 14.5 7.4 17.0 9.3 14.1 37.8 14.9 8.9 10.7 1.8 12.8 3.6 12.6 14.1 12.6 19.7 23.7 19.1 23.8 19.2 19.9 20.7 20.9 20.2 21.1 20.1 20.2 6.9 9.6 2.7 11.4 9.9 18.1 27.3 17.9 18.8 6.2 14.7 19.0 30.2 21.5 9.5 31.3 0.0 21.0 13.9 53.0 101.8 45.9 3.0 4.5 10.8 8.6 7.2 4.2 3.3 57.7 18.6 22.9 13.3 5.4 21.0 13.3 14.3 35.7 35.6 5.0 3.3 45.9 6.1 17.2 26.0 6.4 30.1 14.9 40.9 2.8 14.8 23.9 17.5 5.0 3.4 35.4 38.6 24.8 13.3 6.7 382.8 109.8 7.5 5.4 32.9 15.3 23.2 7.0 7.3 23.0 15.3 8.8 11.2 12.6 96.7 26.9 GUCY1A1 "GC-SA3, GUC1A3, GUCY1A3" ENSG00000164116 "Guanylate cyclase 1 soluble subunit alpha 1" Q02108 4 155666726-155737059 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "cGMP biosynthesis" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in some" "Adipocytes: 38.4;Alveolar cells type 2: 56.1;Breast glandular cells: 37.4;Breast myoepithelial cells: 24.9;Distal tubular cells: 19.6;Ductal cells: 21.8;Smooth muscle cells: 49.4" "Cancer enhanced" "Detected in all" "prostate cancer: 24.9" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "NK-cell: 8.2;non-classical monocyte: 10.1;plasmacytoid DC: 11.5" "Group enriched" "Detected in many" 35 "dendritic cells: 11.5;monocytes: 10.1;NK-cells: 8.2" "Cell line enhanced" "Detected in some" "HAP1: 6.8;HEK 293: 5.5;Karpas-707: 9.7;MOLT-4: 18.5;RPTEC TERT1: 12.1;RT4: 14.2;SH-SY5Y: 8.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010887, HPA056004, HPA058617" Uncertain Supported Nucleoplasm NA NA 7100 "Cluster 40: NK-cells - Unknown function" "Cluster 46: Fibroblasts - ECM organization" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 48: Smooth muscle cells - ECM organization" Nucleoplasm "CAB010887: AB_259901, HPA056004: AB_2683007, HPA058617: AB_2732624" "unprognostic (4.81e-3)" "unprognostic (2.60e-1)" "unprognostic (3.03e-1)" "unprognostic (2.15e-1)" "unprognostic (1.99e-2)" "unprognostic (7.77e-3)" "unprognostic (1.07e-1)" "prognostic favorable (2.38e-4)" "unprognostic (1.85e-3)" "unprognostic (6.46e-2)" "unprognostic (3.42e-2)" "unprognostic (7.16e-2)" "prognostic unfavorable (7.59e-4)" "unprognostic (1.60e-2)" "prognostic unfavorable (3.59e-4)" "unprognostic (2.27e-1)" "unprognostic (6.55e-3)" 14.4 7.8 10.1 17.0 24.1 1.2 15.4 2.8 14.0 14.5 0.1 27.1 8.7 16.1 6.2 7.5 9.5 12.6 33.7 12.7 8.0 15.6 8.0 21.0 8.5 5.3 10.0 5.6 13.1 31.4 3.9 25.9 4.5 25.8 10.3 17.0 5.3 13.9 5.1 2.5 9.2 28.9 8.7 14.1 8.6 1.2 10.2 7.5 7.2 18.7 9.2 7.3 6.6 8.5 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 6.8 0.0 0.0 0.0 5.5 1.3 0.0 0.0 0.0 0.0 0.0 0.8 0.1 0.0 0.0 0.1 0.0 3.6 0.0 9.7 0.0 0.0 18.5 0.0 0.0 0.0 0.2 4.1 0.0 3.0 12.1 14.2 2.5 8.7 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.2 0.2 0.0 2.3 0.1 0.0 0.0 0.0 2.5 0.1 0.0 0.0 0.1 8.2 10.1 11.5 0.0 1.0 10.1 24.1 2.8 14.0 12.7 8.0 5.3 10.0 4.5 8.7 10.2 8.5 38.4 9.6 56.1 0.0 0.6 0.0 0.0 0.0 0.0 0.0 37.4 24.9 0.0 0.0 6.8 11.0 0.0 0.4 1.7 0.0 19.6 21.8 0.0 5.5 9.7 10.9 0.0 0.0 0.0 2.0 0.3 8.3 0.0 15.2 3.8 3.0 0.0 0.0 4.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.0 12.9 2.2 0.0 0.0 0.0 49.4 0.0 0.0 0.0 0.0 0.3 0.6 0.1 0.0 0.0 GUCY1A2 "GC-SA2, GUC1A2" ENSG00000152402 "Guanylate cyclase 1 soluble subunit alpha 2" P33402 11 106674019-107018476 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "cGMP biosynthesis" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 18.4;placenta: 17.9" "Group enriched" "Detected in many" 4 "Excitatory neurons: 353.8;Inhibitory neurons: 141.8;Oligodendrocyte precursor cells: 208.6;Sertoli cells: 105.2;Smooth muscle cells: 107.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ hTERT+: 11.8;BJ hTERT+ SV40 Large T+ RasG12V: 13.4;HBF TERT88: 7.1;TIME: 4.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB009534 Uncertain NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "CAB009534: AB_2279509" "unprognostic (7.53e-2)" "unprognostic (6.67e-2)" "unprognostic (7.99e-2)" "unprognostic (1.10e-1)" "unprognostic (1.08e-1)" "unprognostic (1.22e-2)" "unprognostic (1.23e-2)" "unprognostic (1.24e-1)" "unprognostic (6.53e-3)" "unprognostic (9.70e-3)" "unprognostic (8.00e-2)" "unprognostic (2.03e-1)" "prognostic unfavorable (3.02e-5)" "unprognostic (2.48e-4)" "unprognostic (1.62e-1)" "unprognostic (3.50e-2)" "unprognostic (1.09e-2)" 3.4 2.0 5.3 0.6 18.4 0.0 1.9 1.6 13.8 12.7 0.0 0.7 0.2 12.3 3.1 0.4 5.9 1.5 2.7 7.1 3.9 1.8 1.7 4.6 0.7 4.7 2.6 1.2 4.3 0.6 0.5 17.9 4.9 1.8 0.5 3.5 0.6 6.8 1.8 0.6 0.4 13.1 0.4 6.0 0.3 1.7 8.6 0.2 1.4 3.6 0.3 0.9 2.8 7.4 0.0 0.2 4.0 0.0 0.2 2.4 2.2 0.3 11.8 1.5 13.4 0.0 0.0 0.0 0.0 0.9 0.4 0.0 0.1 0.0 7.1 0.0 1.1 0.0 0.1 0.0 0.2 0.0 1.6 0.6 0.0 1.8 0.2 0.0 0.8 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.4 3.6 0.0 0.7 0.5 0.8 0.2 4.6 3.7 3.0 0.8 1.2 0.0 0.0 0.0 0.1 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.3 18.4 1.6 13.8 7.1 3.9 4.7 2.6 4.9 0.4 8.6 7.4 29.5 0.0 0.5 20.2 0.5 1.7 2.2 0.0 1.2 24.0 0.4 0.9 5.1 0.0 0.0 3.7 12.5 0.1 0.0 0.1 0.0 5.8 2.5 0.9 24.2 12.5 0.0 2.7 353.8 0.2 0.0 8.2 0.0 1.1 0.0 42.7 2.2 0.2 0.4 18.5 141.8 0.0 0.0 0.8 1.5 6.5 24.5 1.1 3.6 18.7 0.0 29.3 0.0 208.6 10.7 0.3 0.0 25.2 1.2 2.4 0.0 0.1 0.0 4.8 105.2 20.7 107.0 1.6 1.5 0.7 1.1 0.3 0.5 19.6 0.0 1.5 GUCY1B1 "GC-S-beta-1, GC-SB3, GUC1B3, GUCY1B3" ENSG00000061918 "Guanylate cyclase 1 soluble subunit beta 1" Q02153 4 155758992-155807811 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "cGMP biosynthesis" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in some" "Adipocytes: 20.2;Ductal cells: 22.9;Glandular and luminal cells: 15.5;Proximal tubular cells: 22.2;Smooth muscle cells: 36.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 8 "intermediate monocyte: 7.2;non-classical monocyte: 23.9" "Lineage enriched" "Detected in many" 13 "monocytes: 23.9" "Cell line enhanced" "Detected in many" "HEL: 46.0;Karpas-707: 23.7;MOLT-4: 29.9;RPTEC TERT1: 42.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010890, HPA020870" Approved Approved Cytosol NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 57: Non-specific - Angiogenesis" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 48: Smooth muscle cells - ECM organization" Cytosol "CAB010890: AB_259911, HPA020870: AB_1850444" "unprognostic (1.44e-1)" "unprognostic (1.25e-1)" "unprognostic (3.55e-2)" "unprognostic (9.10e-3)" "unprognostic (4.69e-2)" "unprognostic (1.41e-2)" "unprognostic (6.88e-2)" "unprognostic (6.69e-3)" "unprognostic (3.03e-3)" "unprognostic (1.47e-1)" "unprognostic (8.37e-2)" "unprognostic (2.84e-1)" "prognostic unfavorable (2.42e-4)" "unprognostic (7.35e-3)" "prognostic unfavorable (3.23e-4)" "unprognostic (2.14e-1)" "unprognostic (6.36e-3)" 13.8 7.1 23.6 15.6 30.0 2.2 10.0 5.3 36.6 12.6 0.0 28.9 5.8 16.4 6.0 8.1 13.7 13.3 18.7 30.1 28.2 13.2 7.7 16.5 10.4 9.8 13.9 5.8 10.9 50.3 6.0 43.6 22.8 13.6 8.7 34.7 5.5 12.2 5.9 3.5 11.1 25.0 6.4 11.0 13.8 2.4 14.8 7.2 7.3 14.9 7.3 10.0 11.1 17.0 0.0 0.5 6.5 0.0 2.2 11.4 0.0 2.0 3.6 0.2 0.1 0.0 0.0 0.0 3.0 1.1 5.0 0.1 13.6 0.3 0.8 0.0 4.6 46.0 0.0 0.0 1.2 0.0 0.0 5.1 0.4 0.0 0.2 4.2 0.1 10.2 0.0 23.7 3.0 2.1 29.9 0.1 0.4 0.0 3.2 3.5 0.9 0.7 42.9 4.4 0.7 7.8 0.0 0.2 0.0 6.4 0.0 0.0 0.0 7.3 1.6 12.4 9.5 0.3 0.0 0.0 15.6 0.0 0.0 1.4 0.5 0.5 0.0 7.2 0.0 0.1 0.0 0.0 1.8 0.2 0.0 0.0 0.5 1.3 23.9 1.6 0.0 5.8 23.6 30.0 5.3 36.6 30.1 28.2 9.8 13.9 22.8 6.4 14.8 17.0 20.2 6.4 7.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.4 2.2 0.0 0.0 0.0 9.2 0.0 1.1 1.1 0.0 5.9 22.9 0.0 3.7 4.3 3.4 0.0 0.0 0.0 4.2 0.2 5.4 0.0 15.5 1.3 4.1 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.6 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.1 0.0 0.0 22.2 0.0 0.0 0.0 0.0 36.1 0.0 0.0 0.0 0.0 0.7 0.4 0.7 0.0 0.0 GUCY2C "GUC2C, STAR" ENSG00000070019 "Guanylate cyclase 2C" P25092 12 14612632-14696599 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, Transporters" "cGMP biosynthesis" "Lyase, Receptor" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 20 "intestine: 68.2" "Cell type enhanced" "Detected in some" "Distal enterocytes: 34.4;Enteroendocrine cells: 176.7;Intestinal goblet cells: 56.0;Paneth cells: 97.9;Proximal enterocytes: 81.5;Undifferentiated cells: 47.6" "Group enriched" "Detected in many" 5 "colorectal cancer: 23.9;stomach cancer: 9.1" "Not detected" "Not detected" "Immune cell enhanced" "Detected in some" "memory B-cell: 1.5" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "AN3-CA: 1.4;CACO-2: 1.1;CAPAN-2: 1.7;SiHa: 1.6" "Region enhanced" "Detected in some" "midbrain: 1.8" "Low region specificity" "Detected in all" "HPA037655, HPA073759" Uncertain Uncertain Vesicles NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 9: Intestine - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 17: Intestinal endocrine cells - Hormone signaling" Vesicles "HPA037655: AB_10672388, HPA073759: " "unprognostic (1.08e-1)" "unprognostic (2.12e-1)" "unprognostic (3.58e-2)" "unprognostic (2.11e-2)" "unprognostic (1.60e-2)" "unprognostic (5.67e-3)" "prognostic unfavorable (1.37e-5)" "unprognostic (9.14e-2)" "unprognostic (1.49e-2)" "unprognostic (2.95e-1)" "unprognostic (1.58e-1)" "unprognostic (5.40e-2)" "unprognostic (2.35e-4)" "unprognostic (8.02e-2)" "unprognostic (1.64e-1)" "unprognostic (1.33e-1)" "unprognostic (1.98e-1)" 0.5 0.2 0.1 3.4 0.3 0.5 0.0 0.2 0.1 0.0 3.0 37.2 68.2 0.3 0.0 1.9 0.0 0.9 2.2 0.2 0.3 0.4 0.3 0.2 0.4 0.4 0.3 0.0 2.2 0.0 0.0 0.2 0.4 0.3 41.4 0.1 0.6 0.0 0.7 1.0 66.5 1.4 0.5 0.2 1.9 0.4 0.3 0.0 0.5 0.0 0.3 0.5 0.2 0.5 0.4 0.0 0.0 1.4 0.0 0.0 0.8 0.0 0.0 0.0 0.0 1.1 1.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.2 1.6 0.1 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.5 0.3 0.4 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.2 0.0 1.5 0.0 0.0 0.3 1.1 0.0 0.0 1.1 0.0 0.0 0.2 0.0 0.2 0.1 0.3 0.2 0.1 0.2 0.3 0.4 0.3 0.4 0.5 0.3 0.5 0.0 0.0 0.0 1.3 6.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 34.4 0.0 0.0 0.1 0.1 0.0 0.0 176.7 0.0 1.4 0.2 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.8 56.0 0.0 0.3 0.3 0.2 0.0 0.3 0.0 1.0 0.3 0.0 0.0 1.0 0.2 0.4 97.9 0.0 0.1 0.0 81.5 0.8 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 47.6 0.0 GUCY2D "CORD6, CYGD, GUC1A4, GUC2D, LCA, LCA1, retGC, RETGC-1, ROS-GC1" ENSG00000132518 "Guanylate cyclase 2D, retinal" Q02846 17 8002615-8020342 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "cGMP biosynthesis, Sensory transduction, Vision" Lyase "Cone-rod dystrophy, Congenital stationary night blindness, Disease variant, Leber congenital amaurosis" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 24 "retina: 34.2" "Group enriched" "Detected in some" 4 "Cone photoreceptor cells: 62.6;Rod photoreceptor cells: 58.3" "Low cancer specificity" "Detected in single" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 31 "plasmacytoid DC: 8.0" "Lineage enriched" "Detected in single" 50 "dendritic cells: 8.0" "Cell line enriched" "Detected in some" 5 "JURKAT: 5.9" "Low region specificity" "Detected in many" "Low region specificity" "Detected in single" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 79: Retina - Phototransduction" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 9: Photoreceptor cells - Phototransduction" "unprognostic (3.57e-4)" "unprognostic (5.05e-1)" "unprognostic (1.49e-1)" "unprognostic (9.75e-5)" "unprognostic (5.94e-2)" "unprognostic (1.86e-1)" "unprognostic (4.44e-2)" "unprognostic (3.81e-2)" "unprognostic (2.92e-1)" "unprognostic (2.26e-1)" "unprognostic (7.54e-2)" "unprognostic (4.44e-1)" "unprognostic (7.59e-5)" "unprognostic (1.05e-1)" "unprognostic (3.46e-1)" "unprognostic (3.08e-1)" "unprognostic (1.07e-1)" 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 34.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.4 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.3 0.1 0.0 0.0 0.0 0.0 0.0 5.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 8.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.1 0.4 1.3 5.2 5.7 2.1 1.4 3.8 1.9 0.0 1.4 0.0 62.6 1.2 2.7 0.0 1.9 0.1 6.9 0.2 0.1 0.1 0.0 0.0 0.5 0.0 0.7 0.1 0.0 0.6 0.0 0.1 0.0 1.2 1.1 0.0 0.4 0.0 0.0 0.6 0.0 14.9 0.0 0.6 0.0 0.0 0.8 6.1 0.0 0.0 0.1 0.1 0.0 0.4 0.0 1.1 0.0 0.4 0.1 58.3 0.0 0.0 0.0 0.4 0.1 2.4 0.3 2.2 0.1 0.0 0.2 0.5 GUCY2F "CYGF, GC-F, GUC2DL, RetGC-2, ROS-GC2" ENSG00000101890 "Guanylate cyclase 2F, retinal" P51841 X 109372906-109482086 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "cGMP biosynthesis, Sensory transduction, Vision" Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 145 "retina: 42.2" "Cell type enriched" "Detected in some" 26 "Rod photoreceptor cells: 31.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "THP-1: 1.0" "Low region specificity" "Detected in single" "Not detected" "Not detected" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 43: THP-1 - Innate immune response" "Cluster 46: Photoreceptor cells - Phototransduction" "unprognostic (1.91e-1)" "unprognostic (4.45e-2)" "unprognostic (2.96e-1)" "unprognostic (2.23e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 42.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 1.1 0.4 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 31.3 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 HACD1 "CAP, PTPLA" ENSG00000165996 "3-hydroxyacyl-CoA dehydratase 1" B0YJ81 10 17589032-17617374 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" "Developmental protein, Lyase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 73.0" "Cell type enriched" "Detected in many" 4 "Cardiomyocytes: 143.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 11 "T-reg: 55.7" "Lineage enriched" "Detected in many" 12 "T-cells: 55.7" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 35: T-regs - Unknown function" "Cluster 38: Heart - Muscle contraction" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 54: Cardiomyocytes - Muscle contraction" "unprognostic (2.73e-2)" "unprognostic (3.26e-2)" "unprognostic (3.54e-1)" "unprognostic (2.62e-2)" "unprognostic (4.10e-1)" "unprognostic (5.67e-3)" "unprognostic (4.21e-2)" "unprognostic (3.04e-2)" "unprognostic (2.38e-1)" "unprognostic (1.70e-2)" "unprognostic (2.61e-2)" "unprognostic (3.43e-1)" "unprognostic (2.46e-2)" "unprognostic (2.93e-2)" "unprognostic (3.40e-2)" "unprognostic (1.10e-1)" "unprognostic (6.49e-2)" 9.7 7.0 3.1 5.0 3.5 8.0 8.8 10.7 4.6 6.8 2.9 31.9 2.8 22.1 3.3 7.8 10.3 3.6 73.0 3.0 6.5 5.0 1.6 9.7 1.3 5.5 5.2 4.3 2.7 0.5 3.7 1.6 5.0 11.9 3.8 2.3 2.7 16.7 36.5 3.0 6.9 25.4 2.4 1.7 15.0 3.5 4.7 2.6 7.6 16.5 1.2 18.1 6.8 8.4 29.3 24.6 6.8 33.4 30.1 5.8 0.6 40.5 24.4 51.9 48.5 16.4 34.6 0.2 5.9 66.4 74.5 7.1 17.3 12.3 28.6 19.1 10.4 67.1 18.4 45.6 39.0 0.3 4.8 14.0 17.2 29.9 11.6 39.8 10.1 35.1 0.6 1.3 69.0 21.0 50.4 6.7 14.6 2.2 6.6 44.7 7.1 0.8 20.5 5.6 7.5 19.1 34.6 0.6 58.9 21.2 24.2 16.7 9.8 30.3 17.4 18.7 18.8 0.9 0.8 0.3 22.3 7.7 4.3 4.7 0.9 0.7 1.2 0.1 0.3 0.4 5.0 1.0 3.0 1.3 0.9 0.7 2.6 3.3 0.3 1.5 55.7 1.3 3.1 3.5 10.7 4.6 3.0 6.5 5.5 5.2 5.0 2.4 4.7 8.4 2.4 28.9 15.0 0.3 0.4 0.0 23.1 0.0 8.0 0.8 6.9 21.6 143.7 10.0 2.5 31.3 0.0 0.5 4.4 0.4 3.9 16.5 11.1 5.6 8.0 5.4 3.6 29.2 10.4 8.0 1.9 7.1 8.2 12.4 6.3 17.5 20.7 1.0 5.4 0.0 11.7 2.5 0.0 2.2 0.0 2.7 1.8 3.6 0.0 5.6 0.8 0.5 1.0 2.5 31.8 15.6 0.8 0.7 0.6 23.9 0.5 2.3 0.7 0.6 0.0 5.7 32.5 7.4 5.2 17.7 0.0 3.0 2.9 10.8 3.5 6.2 HACD2 PTPLB ENSG00000206527 "3-hydroxyacyl-CoA dehydratase 2" Q6Y1H2 3 123490820-123585053 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SiHa: 249.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB019282 Approved NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 59: Non-specific - Transcription" "CAB019282: " "unprognostic (3.04e-2)" "unprognostic (2.51e-1)" "unprognostic (6.11e-2)" "unprognostic (2.65e-3)" "unprognostic (5.36e-2)" "unprognostic (6.04e-2)" "unprognostic (1.32e-2)" "unprognostic (1.95e-2)" "unprognostic (1.96e-1)" "unprognostic (1.22e-1)" "prognostic unfavorable (9.59e-5)" "unprognostic (6.90e-2)" "unprognostic (7.03e-3)" "unprognostic (1.48e-1)" "unprognostic (3.85e-2)" "unprognostic (1.94e-2)" "unprognostic (2.59e-2)" 68.3 11.2 16.2 16.5 23.5 8.7 22.8 19.3 20.5 14.6 8.4 26.7 29.9 16.6 17.7 18.9 13.1 16.7 10.7 16.0 19.7 24.1 48.4 19.4 21.3 19.4 17.1 12.5 17.4 21.3 7.7 15.5 21.0 29.5 27.7 13.8 16.4 12.9 5.3 32.5 25.8 16.7 17.8 12.3 21.2 19.0 16.6 14.9 19.4 8.4 28.6 14.7 17.1 33.9 76.9 42.7 28.8 21.1 88.3 19.5 106.5 53.7 22.2 54.6 39.4 87.9 66.1 44.1 37.8 51.7 63.3 162.8 52.3 67.4 57.3 28.3 17.5 30.8 37.3 68.9 28.7 41.2 29.4 27.2 169.7 26.5 73.6 85.2 29.0 30.0 6.3 42.7 33.4 59.8 19.7 12.3 37.2 92.7 37.4 29.6 31.6 46.9 66.5 48.6 50.5 15.8 249.9 52.7 34.6 41.5 54.9 21.1 22.7 56.8 42.2 57.5 53.1 25.2 34.7 35.9 25.5 28.5 31.1 0.7 1.6 1.1 1.5 1.2 2.2 1.5 1.9 1.9 2.8 2.0 1.8 1.7 0.5 1.3 1.0 1.6 2.5 1.2 16.2 23.5 19.3 20.5 16.0 19.7 19.4 17.1 21.0 17.8 16.6 33.9 19.8 6.4 43.1 8.8 17.5 0.0 28.7 0.0 23.9 9.5 27.8 21.5 13.5 22.8 15.5 46.0 6.2 21.5 18.9 29.4 7.9 15.4 19.8 22.3 14.9 17.0 15.8 15.4 34.3 18.7 16.5 17.3 25.0 35.7 3.8 17.1 16.8 47.5 22.9 1.7 29.7 16.4 0.0 24.2 0.0 10.4 11.5 25.1 0.0 12.2 19.6 14.5 19.6 25.1 32.6 19.6 16.6 17.7 15.0 40.6 33.8 17.8 2.9 13.9 6.6 14.8 11.3 10.5 24.8 35.1 0.0 6.7 14.2 11.8 19.9 33.2 HACD3 "B-ind1, HSPC121, PTPLAD1" ENSG00000074696 "3-hydroxyacyl-CoA dehydratase 3" Q9P035 15 65530418-65578349 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014837, HPA060347" Enhanced Enhanced "Endoplasmic reticulum" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 21: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" "Endoplasmic reticulum" "HPA014837: AB_1855914, HPA060347: AB_2684260" "unprognostic (1.51e-2)" "unprognostic (2.89e-1)" "unprognostic (2.29e-1)" "unprognostic (2.18e-1)" "unprognostic (3.52e-1)" "unprognostic (1.92e-2)" "unprognostic (1.67e-1)" "unprognostic (2.28e-1)" "unprognostic (3.36e-2)" "unprognostic (1.09e-1)" "unprognostic (1.73e-1)" "unprognostic (2.57e-1)" "prognostic favorable (3.09e-5)" "unprognostic (3.44e-2)" "unprognostic (5.33e-2)" "unprognostic (1.10e-2)" "unprognostic (2.04e-2)" 23.1 84.1 56.1 18.5 57.1 17.3 74.4 64.6 67.5 40.2 73.2 30.0 28.9 29.9 43.0 19.2 32.4 34.1 11.8 54.3 87.8 79.6 119.1 30.3 18.8 68.3 79.6 47.8 29.8 61.5 44.2 37.2 87.2 41.6 34.3 54.0 28.6 34.3 6.9 27.7 29.2 28.1 70.0 21.2 68.7 34.6 88.3 29.0 70.8 7.8 20.3 43.0 17.8 75.8 88.9 194.4 211.3 106.2 130.3 78.0 99.8 95.9 82.4 106.6 119.6 149.9 129.1 110.8 81.8 104.7 132.6 237.9 344.4 80.1 94.8 61.9 191.8 88.1 88.7 165.3 65.9 110.6 64.9 80.3 58.7 73.3 52.5 102.7 105.5 65.1 117.5 40.8 174.3 105.6 82.5 86.0 180.6 235.3 65.4 91.8 178.9 125.0 152.1 151.2 126.8 111.9 103.6 114.9 110.5 197.5 117.1 57.9 84.2 134.4 117.6 66.9 134.9 79.1 251.2 154.5 89.7 105.8 82.6 8.5 7.5 2.5 31.7 11.2 36.1 23.7 28.6 30.2 13.2 22.2 33.0 32.9 1.0 23.2 12.7 17.4 24.6 22.7 56.1 57.1 64.6 67.5 54.3 87.8 68.3 79.6 87.2 70.0 88.3 75.8 63.6 64.1 64.8 84.5 18.7 0.0 60.5 0.0 76.2 121.3 94.8 64.5 9.9 62.9 27.9 176.6 100.1 189.1 23.8 6.1 25.4 71.3 107.2 62.8 76.2 51.8 43.7 67.3 57.5 46.3 124.4 62.7 73.4 39.8 16.4 127.0 42.1 165.2 51.2 139.7 97.1 26.3 0.0 23.1 0.0 32.5 87.3 22.2 0.0 29.0 5.2 89.8 16.5 57.8 66.7 32.1 18.2 88.4 28.9 71.5 28.3 56.2 36.5 83.7 78.9 40.9 41.9 156.9 110.3 54.3 0.0 113.1 22.3 136.2 45.1 78.7 HACD4 "Em:AL662879.1, PTPLAD2" ENSG00000188921 "3-hydroxyacyl-CoA dehydratase 4" Q5VWC8 9 20999509-21031640 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 12.0" "Cell type enhanced" "Detected in many" "Hofbauer cells: 60.7;Kupffer cells: 78.8;Macrophages: 99.3;monocytes: 87.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+: 17.2;HDLM-2: 10.8;TIME: 8.6;U-937: 13.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA058666 Uncertain NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 44: HDLM-2 - Immune response" "Cluster 51: Myeloid cells - Hemostasis" "HPA058666: AB_2683793" "unprognostic (1.71e-1)" "unprognostic (2.58e-2)" "unprognostic (5.47e-2)" "unprognostic (1.70e-2)" "unprognostic (7.66e-2)" "unprognostic (1.87e-2)" "unprognostic (2.21e-1)" "unprognostic (1.28e-2)" "unprognostic (1.11e-4)" "prognostic favorable (3.14e-4)" "unprognostic (8.72e-2)" "unprognostic (1.63e-1)" "prognostic unfavorable (6.77e-4)" "unprognostic (3.89e-3)" "unprognostic (7.33e-2)" "unprognostic (1.77e-2)" "unprognostic (2.00e-3)" 1.9 2.8 1.3 3.5 1.2 12.0 2.4 2.0 2.5 5.3 2.7 4.2 2.0 3.5 1.1 2.6 3.9 3.0 0.8 1.2 1.1 2.0 1.1 8.3 4.4 1.1 0.7 3.9 0.5 1.1 0.6 6.4 0.9 2.7 3.1 1.3 1.4 2.2 0.4 2.5 2.9 4.2 0.5 3.9 2.0 1.0 1.0 5.2 2.1 1.5 4.0 2.7 1.8 1.5 4.2 1.2 0.4 0.1 0.0 0.1 0.1 3.8 17.2 3.0 3.4 0.0 0.0 3.7 2.1 7.4 0.0 1.1 0.2 1.6 3.8 10.8 0.1 0.0 1.3 0.0 2.3 3.1 3.2 6.6 6.7 2.7 0.0 0.0 1.0 4.3 0.0 2.1 0.6 0.1 0.0 4.3 0.9 0.0 0.0 0.0 0.0 0.1 0.2 0.5 0.7 0.0 0.9 0.3 0.0 2.4 3.0 5.9 8.6 0.0 0.1 0.2 0.1 0.1 0.1 0.1 0.0 13.4 0.1 21.4 8.8 14.4 2.5 10.9 2.4 1.4 2.7 2.8 10.2 1.3 1.9 2.7 12.4 3.7 11.3 1.1 3.7 5.0 1.3 1.2 2.0 2.5 1.2 1.1 1.1 0.7 0.9 0.5 1.0 1.5 6.3 48.1 6.1 2.3 15.8 0.0 10.7 0.0 16.5 1.6 5.4 5.8 2.1 2.8 11.2 12.9 0.0 12.2 26.1 0.1 5.9 0.6 0.5 33.0 8.4 5.6 0.0 27.1 4.3 0.5 37.9 23.1 4.1 5.6 3.8 17.7 11.7 1.0 60.7 0.0 2.4 0.1 0.0 78.8 0.0 0.4 3.7 99.3 0.0 11.2 87.7 11.0 36.0 0.0 0.4 0.1 0.1 1.2 20.1 3.7 0.0 9.3 48.8 1.6 13.1 4.6 13.4 0.3 7.8 11.7 0.0 5.1 33.1 11.9 0.3 4.5 HACL1 "2-HPCL, HPCL, PHYH2" ENSG00000131373 "2-hydroxyacyl-CoA lyase 1" Q9UJ83 3 15560699-15601852 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 5 "basophil: 117.3" "Lineage enriched" "Detected in all" 5 "granulocytes: 117.3" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035496, HPA035497, HPA073760" Approved Supported Nucleoplasm,Vesicles NA NA "Cluster 38: Basophils - Unknown function" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 28: BEWO - Transcription regulation" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Vesicles Nucleoplasm "HPA035496: AB_10601328, HPA035497: AB_2674653, HPA073760: AB_2686633" "unprognostic (6.64e-3)" "unprognostic (2.82e-2)" "unprognostic (2.24e-3)" "unprognostic (3.82e-1)" "unprognostic (4.08e-2)" "unprognostic (1.77e-1)" "unprognostic (2.96e-2)" "unprognostic (6.31e-2)" "unprognostic (8.27e-3)" "unprognostic (5.23e-2)" "unprognostic (3.30e-2)" "unprognostic (1.44e-1)" "prognostic favorable (2.63e-5)" "unprognostic (6.62e-2)" "unprognostic (2.66e-1)" "unprognostic (3.23e-2)" "unprognostic (9.07e-2)" 14.4 12.0 7.5 8.2 7.8 11.6 14.6 10.4 10.5 9.1 7.9 10.0 56.6 8.3 16.6 7.5 10.8 8.8 11.0 7.6 7.0 26.0 51.8 9.7 14.1 7.4 7.2 7.5 15.2 20.0 7.8 7.8 7.0 10.8 12.0 12.2 9.1 9.1 17.6 10.6 27.7 9.5 7.4 11.4 13.2 26.7 6.8 13.9 20.4 10.6 14.5 10.3 6.4 10.0 15.1 28.6 8.2 30.7 13.4 12.4 82.3 14.2 22.0 26.6 26.3 27.3 14.3 14.6 9.7 18.7 10.5 10.4 18.7 25.3 23.8 13.6 36.4 25.4 17.7 24.7 20.3 30.5 23.1 13.7 16.2 37.9 16.6 8.3 31.4 18.3 24.0 21.2 22.9 28.7 14.0 12.6 19.7 19.7 29.7 14.4 21.5 19.6 26.4 20.2 9.6 12.3 22.4 19.0 25.2 12.8 8.5 25.4 22.5 14.1 14.6 17.4 24.7 27.2 50.9 28.5 27.1 26.4 17.2 117.3 16.0 18.3 14.4 20.1 21.2 15.4 15.5 18.0 16.0 21.2 14.8 16.1 3.4 24.1 24.2 10.2 19.8 13.0 7.5 7.8 10.4 10.5 7.6 7.0 7.4 7.2 7.0 7.4 6.8 10.0 12.4 9.6 17.3 34.9 22.1 10.3 12.0 13.5 20.5 19.3 9.1 10.2 6.4 14.3 15.6 11.0 29.2 27.2 15.7 6.1 13.7 16.0 66.6 12.6 6.0 12.3 9.1 8.2 67.4 25.2 18.0 12.0 11.2 5.4 13.3 12.7 8.9 24.3 13.2 13.5 55.8 7.5 10.2 9.3 8.1 56.8 23.3 8.8 12.4 25.3 19.3 24.8 8.2 40.7 38.8 14.5 11.2 15.4 21.4 9.0 41.9 39.7 29.8 38.3 6.6 9.0 11.2 51.1 24.4 8.6 7.1 18.9 19.4 15.1 10.6 7.9 HADHA "GBP, LCEH, LCHAD, MTPA" ENSG00000084754 "Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha" P40939 2 26190635-26244672 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" "Lyase, Multifunctional enzyme, Oxidoreductase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 502.5" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 527.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015536, HPA056070" Approved Enhanced Mitochondria NA NA 470000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 8: Non-specific - Mitochondria" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 45: Enterocytes - Digestion" Mitochondria "HPA015536: AB_1850473, HPA056070: AB_2683026" "unprognostic (2.02e-1)" "unprognostic (1.38e-2)" "unprognostic (2.55e-1)" "unprognostic (3.43e-1)" "unprognostic (2.67e-2)" "unprognostic (3.23e-2)" "unprognostic (1.25e-2)" "unprognostic (2.02e-1)" "unprognostic (5.16e-2)" "unprognostic (3.45e-1)" "unprognostic (3.81e-1)" "unprognostic (1.16e-1)" "prognostic favorable (3.68e-5)" "unprognostic (7.97e-2)" "unprognostic (1.71e-1)" "unprognostic (2.87e-3)" "unprognostic (2.64e-2)" 105.0 125.3 57.7 31.1 60.7 46.3 94.9 65.0 69.6 72.6 59.1 108.4 115.0 61.8 30.7 90.1 60.1 32.4 330.2 52.8 61.9 99.0 156.7 66.9 35.3 64.4 62.2 77.8 101.4 95.0 57.4 39.2 64.2 60.2 76.1 14.9 77.9 33.4 502.5 95.7 106.2 57.4 61.8 68.4 93.8 49.0 62.4 46.7 59.5 300.7 58.5 79.1 73.6 67.2 105.7 88.1 58.4 90.8 221.1 139.9 51.5 80.6 84.7 78.5 67.7 114.7 104.1 71.7 50.2 138.4 78.6 66.8 103.4 152.6 72.5 139.1 103.6 103.3 86.2 197.9 73.3 132.2 69.2 142.7 101.6 112.4 109.3 82.8 127.7 70.4 140.2 133.2 101.1 128.2 63.4 137.7 50.1 77.5 134.1 52.9 128.5 143.7 90.3 125.3 41.9 85.1 94.6 104.6 102.4 44.5 52.2 125.8 127.1 48.8 70.7 69.9 58.0 44.8 86.5 113.4 77.6 150.2 56.2 22.5 84.0 33.5 31.8 92.3 39.1 40.5 36.8 38.7 80.8 31.2 42.6 40.1 20.9 38.8 86.1 31.3 50.9 89.9 57.7 60.7 65.0 69.6 52.8 61.9 64.4 62.2 64.2 61.8 62.4 67.2 122.4 89.8 99.0 47.0 101.2 89.0 137.5 139.9 97.3 35.6 89.7 96.4 349.9 82.9 128.0 77.3 52.1 182.0 95.1 242.1 131.0 120.8 39.2 73.3 121.1 99.1 91.4 155.9 22.8 108.5 94.7 96.1 100.4 85.5 139.9 140.3 84.3 185.1 163.0 20.2 28.2 156.5 89.5 136.8 106.0 74.3 92.6 145.0 81.8 12.2 170.7 65.4 93.7 30.7 37.4 90.0 195.6 84.2 90.4 76.2 527.4 182.5 84.8 62.3 52.6 129.9 109.6 147.9 54.9 136.5 103.3 129.2 100.5 154.7 216.7 104.4 HAL HIS ENSG00000084110 "Histidine ammonia-lyase" P42357 12 95972662-95996365 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Histidine metabolism" Lyase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 11 "liver: 198.2;skin 1: 61.1" "Cell type enriched" "Detected in some" 8 "Hepatocytes: 129.6" "Cancer enriched" "Detected in some" 11 "liver cancer: 23.7" "Not detected" "Not detected" "Group enriched" "Detected in many" 4 "basophil: 56.9;neutrophil: 73.3" "Lineage enriched" "Detected in many" 5 "granulocytes: 73.3" "Cell line enhanced" "Detected in some" "BEWO: 2.2;NB-4: 2.8;THP-1: 11.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA038547, HPA038548" Enhanced Approved Cytosol NA NA 280000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 85: Liver - Metabolism" "Cluster 43: THP-1 - Innate immune response" "Cluster 15: Hepatocytes - Hemostasis" Cytosol "HPA038547: AB_10669541, HPA038548: AB_10673175" "unprognostic (3.39e-1)" "unprognostic (4.46e-2)" "unprognostic (1.53e-2)" "unprognostic (1.46e-1)" "unprognostic (2.32e-2)" "unprognostic (1.20e-2)" "unprognostic (5.05e-2)" "unprognostic (2.80e-2)" "unprognostic (1.52e-1)" "unprognostic (1.33e-2)" "unprognostic (9.41e-2)" "unprognostic (2.45e-1)" "unprognostic (1.31e-3)" "unprognostic (1.89e-2)" "unprognostic (3.74e-1)" "unprognostic (4.03e-2)" "unprognostic (2.87e-2)" 1.4 0.3 0.1 2.9 0.1 11.5 2.2 0.1 0.4 0.8 0.1 0.5 0.6 0.4 0.0 1.0 0.7 0.6 0.3 0.1 0.1 0.3 198.2 2.3 0.5 0.1 0.1 0.2 0.9 0.1 3.0 0.4 0.1 0.2 0.4 0.0 0.6 0.1 0.2 61.1 0.8 0.5 0.0 7.6 0.4 0.1 0.1 0.5 0.2 0.6 1.4 0.5 1.4 0.2 0.4 0.0 0.1 0.0 0.0 0.0 2.2 0.0 0.1 0.0 0.1 0.0 0.1 0.6 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.1 0.3 0.3 0.1 0.0 0.0 0.4 0.4 0.0 0.6 0.3 0.2 0.1 0.2 0.3 0.0 0.1 0.1 0.0 0.1 2.8 0.9 0.1 0.4 0.2 0.1 0.0 0.1 0.6 0.1 0.3 0.3 0.0 0.0 0.0 0.0 11.4 0.1 0.1 0.1 0.1 0.1 0.4 0.5 0.1 0.0 1.7 0.0 56.9 15.1 2.4 0.0 5.7 0.0 0.0 0.0 0.0 3.4 0.1 0.0 0.0 73.3 0.7 13.6 0.3 0.2 4.4 0.1 0.1 0.1 0.4 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.2 0.2 0.0 1.1 0.0 0.6 0.1 0.1 0.1 0.0 0.0 0.1 0.3 0.7 2.8 0.3 0.0 0.0 0.2 0.1 0.1 0.0 0.1 0.1 3.2 2.0 0.4 0.0 9.7 0.2 0.2 0.7 0.1 0.5 15.0 0.0 0.1 2.5 129.6 0.3 0.0 0.1 0.1 0.0 7.7 0.8 0.0 0.0 3.5 0.0 0.0 6.3 0.0 1.0 0.0 0.0 0.0 1.3 0.0 0.4 0.2 1.2 0.7 0.1 0.0 0.0 0.2 0.2 0.1 0.0 0.0 2.8 0.0 0.6 0.0 0.3 0.1 HCCS "CCHL, MLS" ENSG00000004961 "Holocytochrome c synthase" P53701 X 11111301-11123086 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Lyase "Disease variant, Microphthalmia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002946 Approved Enhanced Mitochondria "Intracellular and membrane" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 8: Non-specific - Mitochondria" "Cluster 18: U-2197 - ECM organization" "Cluster 22: Epithelial cell types - Mixed function" Mitochondria "HPA002946: AB_1079041" "prognostic unfavorable (8.69e-5)" "unprognostic (6.89e-3)" "unprognostic (8.46e-3)" "unprognostic (4.92e-2)" "unprognostic (1.34e-1)" "unprognostic (5.44e-2)" "prognostic unfavorable (1.35e-5)" "unprognostic (9.18e-2)" "unprognostic (2.73e-1)" "unprognostic (2.52e-2)" "unprognostic (2.10e-2)" "unprognostic (1.60e-1)" "prognostic favorable (6.17e-8)" "unprognostic (2.66e-2)" "unprognostic (1.52e-1)" "unprognostic (2.04e-1)" "unprognostic (1.93e-2)" 13.9 16.1 6.2 13.7 6.7 20.5 12.6 7.0 8.4 8.4 8.4 21.6 23.1 9.6 7.6 19.3 8.5 10.8 39.0 7.4 6.8 17.6 22.9 11.5 15.6 6.7 6.2 8.3 9.9 25.1 8.3 13.1 6.4 9.5 21.6 13.5 15.2 10.0 64.4 17.6 20.2 12.5 6.2 14.5 15.3 10.2 6.7 13.0 10.8 57.0 17.1 22.3 11.6 6.1 54.3 60.5 31.8 28.5 25.6 25.2 29.2 52.0 43.0 67.8 57.5 70.7 38.5 34.3 26.3 46.1 80.8 49.8 63.2 51.8 70.5 30.8 48.0 34.1 80.8 38.6 47.3 40.9 39.4 24.2 37.4 67.9 46.5 37.9 49.1 26.1 63.1 41.1 46.3 72.5 28.0 31.4 51.5 36.6 70.1 27.3 59.9 65.4 44.0 44.8 20.9 24.2 54.8 58.7 38.2 66.7 45.6 27.1 48.7 42.4 23.6 110.4 47.0 26.9 29.0 47.8 35.5 28.8 42.7 25.6 47.8 30.1 20.2 66.4 19.0 39.0 19.6 18.2 62.2 34.7 17.1 22.1 13.1 19.1 57.4 56.2 23.5 19.0 6.2 6.7 7.0 8.4 7.4 6.8 6.7 6.2 6.4 6.2 6.7 6.1 15.5 6.4 4.8 2.3 20.8 54.8 53.2 57.0 22.8 5.3 16.1 13.7 49.3 17.2 33.3 16.5 0.0 32.9 12.4 44.6 50.9 34.9 13.7 19.0 10.4 21.0 10.8 32.8 3.8 29.3 37.9 17.1 12.8 16.7 13.3 10.4 15.7 18.5 41.8 8.4 4.5 19.2 67.1 21.0 44.1 2.3 13.4 23.5 24.9 1.9 27.9 13.0 7.2 2.0 2.7 68.4 31.9 10.5 18.4 63.5 46.4 36.0 28.9 7.1 6.6 12.5 20.1 24.4 28.4 21.8 46.0 40.9 12.0 15.6 30.2 88.6 HDC ENSG00000140287 "Histidine decarboxylase" P19113 15 50241947-50265965 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Catecholamine biosynthesis" "Decarboxylase, Lyase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "brain: 102.9;epididymis: 46.1" "Cell type enriched" "Detected in some" 12 "granulocytes: 596.0" "Cancer enhanced" "Detected in some" "breast cancer: 2.9;testis cancer: 2.7" "Region enriched" "Detected in many" 6 "hypothalamus: 102.9" "Immune cell enriched" "Detected in single" 2140 "basophil: 686.2" "Lineage enriched" "Detected in single" 2140 "granulocytes: 686.2" "Group enriched" "Detected in some" 4 "HEL: 460.8;HMC-1: 1051.3" "Region enriched" "Detected in many" 5 "hypothalamus: 43.9" "Group enriched" "Detected in some" 10 "hypothalamus: 16.5;midbrain: 4.2" HPA038891 Enhanced Approved "Nuclear bodies" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 60: Granulocytes - Receptor signaling" "Nuclear bodies" "HPA038891: AB_10673231" "unprognostic (4.97e-2)" "unprognostic (7.42e-2)" "unprognostic (1.43e-4)" "unprognostic (1.08e-1)" "unprognostic (6.16e-2)" "unprognostic (3.93e-7)" "unprognostic (4.18e-5)" "unprognostic (8.79e-3)" "unprognostic (1.48e-1)" "unprognostic (8.46e-2)" "unprognostic (4.60e-2)" "unprognostic (1.05e-1)" "unprognostic (2.53e-1)" "unprognostic (7.20e-2)" "unprognostic (9.78e-2)" "unprognostic (2.15e-1)" "unprognostic (1.50e-1)" 2.3 0.4 0.0 3.5 5.6 4.7 1.4 0.0 0.2 2.3 0.7 3.8 4.1 2.5 46.1 4.8 0.8 11.2 0.7 0.2 102.9 0.4 0.5 6.9 0.9 0.0 13.7 0.1 1.2 0.5 0.4 0.4 0.0 1.7 3.6 0.8 1.3 0.9 0.3 2.3 4.6 2.5 0.0 0.5 12.9 1.3 17.8 0.9 0.1 0.8 1.0 3.8 1.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.1 0.0 460.8 0.2 0.0 0.0 1.2 1051.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.2 0.0 0.0 0.5 181.8 0.3 0.0 0.0 0.2 0.4 0.4 0.0 0.0 0.0 0.2 0.2 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.5 0.0 0.0 0.5 0.2 0.4 686.2 0.0 0.1 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.2 0.0 0.1 0.0 0.0 1.6 0.0 5.6 0.0 0.2 0.2 102.9 0.0 13.7 0.0 0.0 17.8 0.1 0.0 12.8 47.5 0.3 0.0 0.8 0.0 0.0 0.0 2.6 0.0 0.0 0.5 0.0 7.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 1.2 0.0 10.9 0.3 0.0 0.0 2.3 9.2 0.0 596.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.0 1.8 0.4 0.0 1.2 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 3.8 0.0 0.0 0.0 4.5 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.9 0.0 3.5 0.0 0.1 0.1 HMGCL HL ENSG00000117305 "3-hydroxy-3-methylglutaryl-CoA lyase" P35914 1 23801885-23838620 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Lyase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 322.5" "Cell type enhanced" "Detected in all" "Hepatocytes: 172.4;Proximal tubular cells: 216.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004727 Enhanced "Intracellular and membrane" NA NA 34000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 85: Liver - Metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA004727: AB_1079074" "unprognostic (8.24e-2)" "unprognostic (3.21e-2)" "prognostic favorable (7.67e-4)" "unprognostic (1.23e-3)" "unprognostic (5.47e-3)" "unprognostic (1.26e-1)" "unprognostic (2.04e-1)" "unprognostic (3.85e-2)" "unprognostic (1.08e-1)" "unprognostic (2.24e-1)" "unprognostic (3.05e-1)" "unprognostic (8.24e-2)" "prognostic favorable (5.07e-8)" "unprognostic (1.72e-1)" "unprognostic (2.46e-2)" "unprognostic (8.60e-2)" "unprognostic (3.39e-3)" 27.5 63.0 26.3 16.8 27.5 7.5 25.8 27.5 28.3 27.5 33.0 53.3 45.7 20.2 47.2 32.8 35.6 26.3 42.5 24.6 26.9 115.5 322.5 23.6 21.7 28.0 26.2 21.6 33.4 60.2 26.3 19.9 27.7 31.7 52.9 16.1 30.3 27.9 63.7 25.5 40.0 23.3 27.4 26.8 40.9 17.9 30.1 23.4 40.5 70.2 25.1 28.6 24.2 29.6 28.5 16.0 17.7 13.4 70.6 53.5 6.8 22.0 38.3 23.3 28.2 10.2 53.7 14.8 44.3 34.6 19.0 22.4 21.3 35.7 25.2 30.4 16.1 19.8 13.8 23.5 90.9 7.8 12.7 62.4 52.0 30.8 58.5 62.5 32.2 27.4 20.6 20.3 43.3 29.3 12.2 15.3 4.6 77.4 22.1 17.2 14.5 27.9 55.4 14.5 14.8 13.2 28.6 10.8 49.3 23.3 33.9 19.3 24.3 19.3 11.6 35.5 9.7 28.7 15.2 13.3 47.7 28.7 23.0 103.5 67.0 66.0 36.3 66.0 39.8 45.9 39.1 42.1 58.0 51.2 39.6 37.7 25.5 54.4 77.5 43.9 45.5 61.7 26.3 27.5 27.5 28.3 24.6 26.9 28.0 26.2 27.7 27.4 30.1 29.6 19.9 12.8 25.7 14.0 16.3 5.9 29.9 54.3 9.6 24.6 19.9 17.1 33.7 41.5 30.6 49.7 18.8 43.0 10.0 48.1 119.3 57.7 2.3 25.0 17.5 22.5 9.0 18.7 4.3 24.0 27.3 20.8 30.5 23.1 17.7 29.7 30.4 172.4 61.6 35.3 5.3 49.5 28.5 23.5 7.7 3.6 21.8 23.5 21.4 8.4 41.4 37.1 24.7 6.0 12.5 31.2 53.8 24.5 8.3 29.4 70.9 216.8 31.5 25.5 6.6 17.1 21.6 6.6 5.4 13.8 6.5 41.3 15.2 65.6 48.9 24.3 HMGCLL1 "bA418P12.1, DKFZP434G1411" ENSG00000146151 "3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1" Q8TB92 6 55434373-55579197 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 10.6" "Cell type enhanced" "Detected in some" "Astrocytes: 49.9;Excitatory neurons: 80.7;Inhibitory neurons: 76.2;Oligodendrocytes: 23.5" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "SCLC-21H: 5.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "unprognostic (2.74e-3)" "unprognostic (1.54e-2)" "unprognostic (4.08e-3)" "unprognostic (6.11e-2)" "unprognostic (1.41e-1)" "unprognostic (9.54e-3)" "unprognostic (8.97e-3)" "unprognostic (2.12e-2)" "unprognostic (9.27e-3)" "unprognostic (4.11e-2)" "unprognostic (1.18e-4)" "unprognostic (3.13e-3)" "unprognostic (7.57e-2)" "unprognostic (2.55e-1)" "unprognostic (1.52e-1)" 1.4 3.6 6.1 0.2 5.9 0.0 1.4 5.9 5.2 0.8 0.0 0.8 0.2 0.2 0.0 1.0 0.4 0.6 1.8 5.5 10.6 0.9 0.7 2.6 0.3 5.6 6.3 0.4 1.6 0.1 4.7 6.2 6.6 3.0 0.8 4.5 0.8 1.0 1.1 0.1 0.9 0.5 9.2 0.0 1.0 2.6 8.3 0.6 0.4 2.8 0.2 0.9 0.7 9.4 0.0 0.4 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.9 0.2 0.0 0.0 0.0 1.1 0.5 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.1 5.9 5.9 5.2 5.5 10.6 5.6 6.3 6.6 9.2 8.3 9.4 0.6 0.0 1.3 49.9 0.0 0.0 0.0 0.0 1.2 15.1 3.7 2.4 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.1 0.5 0.0 0.0 80.7 0.0 0.0 5.8 0.0 0.0 0.0 3.5 3.9 0.0 0.1 0.0 76.2 0.0 0.0 0.3 0.0 1.3 0.3 0.1 0.0 15.0 0.0 1.5 0.0 5.5 23.5 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.3 0.0 0.9 5.6 1.3 1.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 HOGA1 "C10orf65, DHDPS2, DHDPSL, FLJ37472, NPL2" ENSG00000241935 "4-hydroxy-2-oxoglutarate aldolase 1" Q86XE5 10 97584323-97612802 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Lyase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 51.8;liver: 54.8" "Cell type enhanced" "Detected in some" "Cholangiocytes: 35.8;Distal tubular cells: 29.4;Hepatocytes: 43.3;Late spermatids: 18.4;Proximal tubular cells: 98.0" "Group enriched" "Detected in many" 5 "liver cancer: 4.5;renal cancer: 9.7" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "AN3-CA: 7.8;EFO-21: 9.7;Hep G2: 26.1;RPTEC TERT1: 31.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA039466 Approved NA NA 16000 "Cluster 33: Neutrophils - Chromatin organization" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA039466: AB_2676522" "unprognostic (6.44e-2)" "unprognostic (3.64e-2)" "unprognostic (7.50e-2)" "unprognostic (2.05e-1)" "unprognostic (1.44e-1)" "unprognostic (3.29e-2)" "unprognostic (1.16e-2)" "unprognostic (2.59e-3)" "unprognostic (4.72e-1)" "unprognostic (2.37e-1)" "unprognostic (1.28e-1)" "unprognostic (6.80e-2)" "prognostic favorable (9.08e-4)" "unprognostic (2.20e-1)" "unprognostic (1.80e-1)" "unprognostic (2.94e-3)" "unprognostic (7.20e-4)" 4.1 8.3 5.8 0.2 7.4 0.4 1.9 9.3 5.0 0.7 11.4 0.2 0.3 1.1 3.7 1.0 2.0 2.5 21.1 4.4 6.5 51.8 54.8 1.4 0.3 8.2 9.2 0.2 15.3 5.7 3.6 0.1 8.3 1.1 0.1 0.8 1.7 2.1 3.4 1.5 0.3 0.5 7.3 0.4 0.2 0.9 7.9 0.3 1.8 12.1 0.2 0.4 0.9 10.3 0.3 3.7 0.1 7.8 1.5 0.3 0.1 0.1 0.2 0.0 0.0 3.0 0.2 0.3 9.7 0.2 0.5 2.6 0.0 0.2 0.1 0.1 4.0 0.1 1.4 26.1 1.1 0.2 0.1 0.3 0.7 0.1 0.1 1.9 0.4 0.1 0.0 0.4 0.6 1.6 0.1 0.1 0.2 0.2 0.0 0.1 0.6 0.4 31.5 0.6 0.6 1.0 0.1 1.3 0.5 0.2 2.8 0.0 0.2 0.8 0.2 0.3 0.2 0.5 0.9 0.1 2.0 0.1 0.1 0.6 0.2 0.2 0.2 0.2 0.2 0.2 0.3 0.2 0.1 0.4 0.2 0.2 1.0 0.2 0.2 0.3 0.2 0.1 5.8 7.4 9.3 5.0 4.4 6.5 8.2 9.2 8.3 7.3 7.9 10.3 0.0 0.0 0.0 7.2 1.5 0.1 0.7 0.5 1.8 0.4 0.1 0.4 6.0 35.8 0.2 9.2 0.0 0.1 0.0 0.1 29.4 5.9 3.8 1.8 0.1 0.0 0.0 0.0 1.3 0.2 0.0 0.2 0.0 0.5 0.0 0.1 0.4 43.3 0.1 1.7 1.2 0.0 0.0 1.3 0.0 18.4 0.0 0.8 1.8 1.0 0.0 2.0 0.0 1.5 12.3 0.5 0.1 0.0 0.0 0.1 0.0 98.0 3.2 0.3 0.0 4.5 0.9 0.0 0.1 0.7 0.0 0.0 0.5 0.0 0.0 0.2 HSD17B4 "DBP, MFE-2, SDR8C1" ENSG00000133835 "Hydroxysteroid 17-beta dehydrogenase 4" P51659 5 119452473-119637199 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" "Isomerase, Lyase, Oxidoreductase" "Deafness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 320.0" "Cell type enhanced" "Detected in all" "Hepatocytes: 225.1;Oligodendrocytes: 221.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 75.5" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021302, HPA021311, HPA021479" Enhanced Enhanced Peroxisomes NA NA 450000 "Cluster 2: Granulocytes - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Peroxisomes "HPA021302: AB_1844350, HPA021311: AB_1844351, HPA021479: AB_1844352" "unprognostic (1.03e-1)" "unprognostic (1.05e-1)" "prognostic favorable (1.33e-4)" "unprognostic (3.21e-2)" "unprognostic (1.24e-2)" "unprognostic (3.12e-2)" "unprognostic (2.83e-3)" "unprognostic (5.47e-2)" "unprognostic (1.54e-1)" "unprognostic (2.03e-2)" "unprognostic (1.02e-1)" "unprognostic (3.85e-1)" "prognostic favorable (6.31e-6)" "unprognostic (1.60e-1)" "unprognostic (8.26e-2)" "unprognostic (1.80e-1)" "unprognostic (6.65e-3)" 74.4 85.0 37.2 41.9 50.2 19.7 44.4 51.1 50.0 68.8 47.2 64.5 79.3 34.1 53.0 50.9 39.1 52.5 68.6 34.9 50.7 84.4 320.0 75.6 33.2 50.6 49.5 34.8 55.2 75.5 26.5 53.4 49.2 56.8 65.9 27.2 44.9 79.0 59.8 51.8 87.6 39.5 44.7 36.6 53.8 20.9 49.9 31.9 133.9 52.8 39.7 57.7 31.5 56.3 68.8 59.8 104.1 143.7 261.8 120.3 57.9 63.4 80.3 57.3 103.0 49.4 112.8 84.4 128.0 70.6 81.0 68.7 77.0 144.4 84.3 94.6 79.8 118.1 62.0 96.9 65.8 38.0 169.9 110.0 56.3 64.9 54.7 69.3 103.9 59.4 41.0 48.9 64.2 64.0 59.2 23.6 82.1 161.1 43.1 68.7 103.0 104.8 92.2 192.7 81.1 70.6 149.0 23.4 78.7 93.3 88.7 68.2 67.6 52.7 38.1 66.5 53.1 26.3 55.3 32.6 63.7 104.4 56.7 75.5 27.3 49.9 6.5 15.5 7.3 11.1 5.8 5.3 21.3 10.3 5.5 5.2 4.9 6.9 17.1 13.8 4.1 12.2 37.2 50.2 51.1 50.0 34.9 50.7 50.6 49.5 49.2 44.7 49.9 56.3 38.9 73.7 125.2 47.3 28.2 14.9 42.5 43.2 24.5 19.7 31.1 22.1 76.4 64.3 52.3 36.8 14.6 64.3 19.1 40.0 84.1 39.9 8.8 29.0 48.9 32.3 33.0 42.1 92.9 35.8 29.3 35.6 48.4 35.8 68.4 25.3 32.2 225.1 77.9 15.2 102.8 45.8 22.4 51.8 13.8 13.4 34.5 46.7 8.8 49.6 85.7 47.3 9.2 78.4 221.5 20.5 29.6 51.1 23.1 24.8 85.7 65.4 33.8 18.6 6.6 29.2 32.2 30.6 22.7 34.7 17.2 65.0 15.7 57.2 55.3 39.7 HTD2 ENSG00000255154 "Hydroxyacyl-thioester dehydratase type 2" P86397 3 58306262-58320193 "Enzymes, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 44.1" "Cell type enhanced" "Detected in some" "Club cells: 1.3;granulocytes: 1.3" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA066812, HPA077228" Approved Supported Nucleoli,Mitochondria NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 60: Granulocytes - Receptor signaling" Mitochondria Nucleoli "HPA066812: AB_2685727, HPA077228: " "unprognostic (1.95e-1)" "unprognostic (3.20e-2)" "unprognostic (1.63e-1)" "unprognostic (2.63e-2)" "unprognostic (2.28e-2)" "unprognostic (2.01e-1)" "unprognostic (2.56e-1)" "unprognostic (2.05e-1)" "unprognostic (9.19e-3)" "unprognostic (1.11e-1)" "unprognostic (7.41e-2)" "unprognostic (1.04e-1)" "unprognostic (1.99e-1)" "unprognostic (7.50e-2)" "unprognostic (3.86e-2)" "unprognostic (1.24e-1)" "unprognostic (2.33e-2)" 7.7 7.2 4.3 6.5 5.0 7.2 8.7 7.3 5.5 6.8 4.7 8.9 12.1 8.4 5.9 8.7 7.8 6.8 12.5 4.8 5.6 11.1 15.2 5.7 6.8 3.6 4.6 12.1 7.4 12.0 5.7 6.7 4.6 7.1 9.1 9.2 7.4 8.6 44.1 7.9 8.7 7.6 4.3 7.2 7.0 7.4 4.5 6.6 10.4 37.8 8.0 6.9 4.9 5.5 10.4 7.1 10.9 8.7 11.6 11.2 15.1 13.8 10.2 17.0 14.4 15.9 7.7 19.9 4.0 10.1 12.8 8.7 18.5 12.6 16.8 11.0 13.1 13.7 16.1 13.9 11.3 16.7 11.4 15.1 15.1 17.3 11.4 11.0 14.6 14.3 12.2 19.9 11.1 6.4 11.2 8.9 17.2 10.2 17.3 7.2 7.2 14.7 12.5 13.8 7.0 10.5 8.4 9.4 17.2 12.1 10.9 15.9 8.1 14.5 10.8 14.3 17.2 15.4 27.6 15.7 12.7 11.9 9.8 17.9 19.2 29.2 19.7 23.7 21.5 28.1 20.0 25.2 20.2 27.6 27.5 21.3 13.6 24.9 20.4 24.5 15.6 15.7 4.3 5.0 7.3 5.5 4.8 5.6 3.6 4.6 4.6 4.3 4.5 5.5 0.1 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 1.3 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.3 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 KYAT1 "CCBL1, GTK, KATI" ENSG00000171097 "Kynurenine aminotransferase 1" Q16773 9 128832942-128882494 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Aminotransferase, Lyase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in some" 6 "Granulosa cells: 45.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "HPA021176, HPA021177, HPA027736" Approved Supported Cytosol NA NA 22000 "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 20: HeLa - Mitochondria" "Cluster 40: Granulosa cells - Unknown function" Cytosol "HPA021176: AB_1846120, HPA021177: AB_1846119, HPA027736: AB_10611818" "unprognostic (6.51e-2)" "unprognostic (8.67e-3)" "unprognostic (1.05e-2)" "unprognostic (5.98e-3)" "unprognostic (2.15e-2)" "unprognostic (5.44e-2)" "unprognostic (2.91e-2)" "unprognostic (1.12e-2)" "unprognostic (2.47e-1)" "unprognostic (8.60e-3)" "unprognostic (1.43e-1)" "unprognostic (3.65e-2)" "unprognostic (3.10e-2)" "unprognostic (5.79e-2)" "unprognostic (2.03e-1)" "unprognostic (1.08e-1)" "unprognostic (1.98e-1)" 3.5 4.7 12.3 3.6 13.3 2.3 4.0 13.0 15.5 7.2 10.6 4.7 2.5 5.8 2.9 5.3 6.4 2.7 10.3 12.1 11.8 7.8 12.7 3.6 5.0 13.2 12.3 6.2 3.1 5.5 8.7 2.5 12.8 7.4 1.3 7.5 4.2 4.3 12.6 7.7 4.2 3.1 12.3 5.4 4.9 5.6 12.9 8.9 6.1 8.7 4.8 7.2 6.7 18.0 4.8 9.8 9.3 10.6 6.9 11.4 3.0 5.5 8.0 6.2 8.0 3.9 9.7 8.3 2.9 4.6 7.0 14.9 13.9 11.1 9.3 10.0 7.3 5.7 27.7 9.6 7.7 5.0 1.9 4.5 7.1 7.1 7.7 21.8 11.3 22.7 8.2 9.0 8.5 3.1 14.0 3.4 15.2 18.3 7.6 16.4 6.4 18.9 8.7 1.7 10.5 7.4 9.9 2.9 6.2 12.8 6.6 1.6 7.0 4.6 7.9 7.1 5.0 15.2 11.0 11.6 9.6 8.3 3.2 0.1 1.4 2.9 5.1 1.8 4.5 7.7 5.7 6.0 5.5 3.3 5.9 6.7 0.9 3.3 2.9 2.4 7.0 3.3 12.3 13.3 13.0 15.5 12.1 11.8 13.2 12.3 12.8 12.3 12.9 18.0 2.6 0.0 1.5 0.0 1.5 0.0 0.0 0.0 0.0 0.0 2.0 1.5 0.0 0.0 0.6 0.0 0.0 5.0 0.9 0.0 3.9 1.6 0.0 2.6 3.3 0.7 0.0 0.0 0.0 0.2 2.4 0.7 0.0 4.2 0.0 45.1 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.3 0.0 0.0 7.3 2.9 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 2.1 1.3 1.3 0.0 0.0 KYAT3 "CCBL2, KAT3, KATIII, RBM1, RP11-82K18.3" ENSG00000137944 "Kynurenine aminotransferase 3" Q6YP21 1 88935773-88992953 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Aminotransferase, Lyase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 70.7;Exocrine glandular cells: 38.2;Extravillous trophoblasts: 39.9;Proximal tubular cells: 35.6;Syncytiotrophoblasts: 83.5;Theca cells: 43.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026538, HPA027168" Enhanced Approved "Nucleoli,Cytokinetic bridge,Cytosol" Yes NA "Cluster 27: Non-specific - Gene expression" "Cluster 1: Thyroid gland - Transcription" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 7: Non-specific - Mitochondria" Cytosol "Nucleoli, Cytokinetic bridge" "HPA026538: AB_1852076, HPA027168: AB_1852078" "prognostic favorable (3.19e-5)" "unprognostic (3.36e-3)" "unprognostic (1.88e-2)" "unprognostic (1.62e-1)" "unprognostic (2.01e-2)" "prognostic favorable (1.86e-4)" "unprognostic (2.61e-1)" "unprognostic (3.61e-3)" "unprognostic (2.11e-1)" "prognostic favorable (2.80e-4)" "unprognostic (1.04e-1)" "unprognostic (3.17e-1)" "prognostic favorable (5.02e-6)" "unprognostic (1.17e-1)" "unprognostic (1.06e-1)" "unprognostic (2.51e-1)" "unprognostic (2.78e-1)" 19.3 22.5 8.3 16.0 9.3 13.4 29.8 10.0 12.2 18.0 12.3 19.9 22.6 21.3 21.7 26.5 18.3 20.0 11.3 9.4 9.5 30.5 27.4 15.4 22.1 8.5 9.5 25.7 30.0 33.4 15.2 22.7 9.2 21.1 21.7 11.0 20.5 22.1 10.6 18.8 17.4 15.7 8.7 17.6 22.7 9.9 8.7 21.6 26.2 10.0 23.7 24.6 14.9 8.9 55.1 11.1 52.2 18.0 19.1 51.2 46.4 31.7 57.2 39.8 49.4 15.6 18.9 35.6 23.8 23.8 27.3 15.7 15.6 25.6 57.7 22.7 21.3 32.4 9.8 26.8 61.8 45.6 8.5 44.9 25.2 29.0 50.1 26.8 37.0 41.0 41.5 19.0 37.9 17.8 48.0 21.6 31.0 42.5 10.3 49.3 36.2 19.2 87.0 49.2 38.9 45.6 44.4 60.0 29.1 31.8 33.3 13.9 27.7 17.5 11.4 55.5 23.1 23.7 13.6 23.6 8.4 19.5 14.7 8.3 12.1 7.5 8.0 7.7 11.1 8.6 10.6 9.5 16.3 8.9 10.6 9.3 8.8 11.3 10.2 5.9 16.3 8.3 8.3 9.3 10.0 12.2 9.4 9.5 8.5 9.5 9.2 8.7 8.7 8.9 10.6 12.8 11.0 0.0 4.1 0.0 0.0 0.0 0.0 0.0 16.0 13.7 0.0 0.0 8.1 12.9 0.0 70.7 13.1 0.0 25.4 34.4 0.0 12.7 14.1 4.6 0.0 0.0 0.0 38.2 39.9 10.1 0.0 14.3 5.1 17.5 0.0 0.0 24.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.1 0.0 0.0 32.0 0.0 0.0 0.0 0.0 25.2 0.0 0.0 1.8 0.0 0.0 35.6 3.6 0.0 0.0 0.0 8.2 0.0 0.0 0.0 0.0 83.5 7.6 43.3 0.0 0.0 L3HYPDH "C14orf149, FLJ25436" ENSG00000126790 "Trans-L-3-hydroxyproline dehydratase" Q96EM0 14 59460363-59484408 "Enzymes, Predicted intracellular proteins" Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Proximal tubular cells: 47.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056694 Approved Uncertain Vesicles NA NA 49000 "Cluster 48: NK-cells - Unknown function" "Cluster 1: Thyroid gland - Transcription" "Cluster 17: WM-115 - Nervous system development" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Vesicles "HPA056694: AB_2683210" "unprognostic (3.39e-2)" "unprognostic (5.55e-3)" "unprognostic (3.81e-2)" "unprognostic (5.86e-2)" "unprognostic (1.10e-1)" "unprognostic (5.06e-2)" "unprognostic (8.34e-2)" "unprognostic (1.16e-1)" "unprognostic (7.24e-2)" "unprognostic (9.50e-2)" "unprognostic (1.26e-3)" "unprognostic (6.60e-2)" "prognostic unfavorable (1.72e-9)" "unprognostic (1.16e-1)" "unprognostic (2.22e-1)" "unprognostic (1.05e-1)" "unprognostic (1.14e-1)" 18.1 14.0 4.8 12.5 5.2 4.8 16.3 9.9 6.6 15.9 10.0 10.6 11.0 16.0 8.5 9.2 15.4 11.5 14.8 5.0 5.8 17.4 17.3 11.2 17.5 7.9 5.8 18.0 12.6 12.2 14.8 10.4 7.4 13.5 10.2 5.2 13.0 11.9 8.9 9.7 13.8 11.9 5.6 13.0 10.5 17.1 4.8 4.3 16.6 5.6 13.7 13.4 14.5 8.3 12.0 31.8 6.8 16.2 14.4 37.6 9.5 31.7 25.1 17.9 17.4 6.4 21.1 4.1 13.0 17.7 31.8 31.8 11.1 17.0 17.7 7.0 14.4 11.0 30.1 23.7 16.2 10.0 7.6 27.3 11.4 18.0 27.6 27.8 22.3 11.3 14.8 18.4 18.8 14.3 3.8 16.4 10.9 4.7 28.5 5.5 11.1 16.6 28.7 6.8 6.9 9.9 29.8 12.2 11.9 5.6 12.8 6.4 31.3 20.9 25.6 16.4 37.5 4.7 2.3 4.0 35.9 8.3 41.7 0.0 3.5 0.5 3.2 5.1 2.4 1.5 1.7 2.0 5.7 1.4 2.5 0.9 0.0 5.6 2.4 3.2 0.8 1.8 4.8 5.2 9.9 6.6 5.0 5.8 7.9 5.8 7.4 5.6 4.8 8.3 11.2 3.2 6.1 11.1 10.9 5.2 5.4 4.2 6.2 2.9 5.6 8.6 8.7 5.7 4.3 3.7 2.1 13.7 3.5 1.0 7.9 7.7 12.2 6.8 17.5 8.1 3.0 5.5 26.7 2.5 11.4 16.0 4.6 2.3 14.0 6.5 11.0 16.8 8.3 1.7 18.9 4.3 4.1 4.6 2.9 7.4 19.3 4.9 3.6 10.3 3.5 4.6 4.1 10.6 17.1 4.4 1.0 12.0 5.5 6.6 3.4 47.0 17.3 2.7 13.1 17.4 11.6 14.1 5.7 7.5 3.4 4.9 6.0 11.9 3.5 2.0 LTC4S MGC33147 ENSG00000213316 "Leukotriene C4 synthase" Q16873 5 179793980-179796647 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Leukotriene biosynthesis, Lipid biosynthesis, Lipid metabolism" "Lyase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in many" 4 "granulocytes: 327.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Group enriched" "Detected in many" 5 "basophil: 20.2;eosinophil: 63.1" "Lineage enriched" "Detected in many" 7 "granulocytes: 63.1" "Cell line enriched" "Detected in some" 11 "HMC-1: 102.0" "Low region specificity" "Detected in many" HPA044688 Approved "Nucleoplasm,Endoplasmic reticulum,Cytosol" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 3: HMC-1 - Innate immune response" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "Endoplasmic reticulum, Cytosol" "HPA044688: " "unprognostic (8.94e-2)" "unprognostic (2.40e-2)" "unprognostic (9.35e-3)" "unprognostic (3.57e-2)" "unprognostic (1.24e-2)" "unprognostic (9.40e-2)" "unprognostic (4.53e-5)" "unprognostic (2.27e-2)" "unprognostic (1.06e-1)" "unprognostic (9.99e-2)" "unprognostic (2.65e-1)" "unprognostic (1.98e-2)" "unprognostic (4.62e-1)" 8.9 6.9 1.1 0.5 0.8 2.3 5.5 1.5 1.3 4.2 0.7 3.3 0.7 5.7 0.0 3.1 11.8 0.3 12.4 1.0 1.4 7.1 1.9 7.7 0.2 2.1 1.5 5.7 2.0 0.2 3.5 0.4 1.4 4.8 0.2 0.0 4.3 0.8 1.0 3.1 3.2 0.4 2.9 6.1 3.0 1.5 2.6 0.0 5.9 0.0 0.1 4.8 4.0 4.7 0.1 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.9 0.9 8.9 0.2 0.4 0.3 0.6 102.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.1 0.1 6.5 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.0 3.2 0.5 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.3 1.0 0.1 20.2 0.5 63.1 0.8 0.6 3.0 0.3 2.1 1.5 8.6 0.2 0.4 1.0 0.3 4.7 0.0 0.4 0.2 0.6 1.1 0.8 1.5 1.3 1.0 1.4 2.1 1.5 1.4 2.9 2.6 4.7 32.3 0.0 3.2 2.9 2.3 9.9 9.6 11.2 14.8 0.4 26.4 38.6 0.0 14.3 6.2 14.7 0.0 10.4 5.0 0.6 1.9 5.9 0.3 4.0 1.5 49.5 3.0 2.1 0.8 2.4 1.9 8.3 3.1 5.6 327.4 0.5 72.1 0.9 41.5 0.0 0.7 1.7 0.0 20.8 46.3 0.9 16.4 53.9 1.8 28.1 2.0 0.1 2.1 1.0 1.5 1.9 0.5 47.4 10.0 3.7 2.2 54.8 5.8 0.5 0.0 0.8 1.6 0.1 0.7 5.2 7.0 3.0 10.0 1.5 3.1 10.0 MGST2 MGST-II ENSG00000085871 "Microsomal glutathione S-transferase 2" Q99735 4 139665768-139740745 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Leukotriene biosynthesis, Lipid metabolism" "Lyase, Oxidoreductase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 393.2" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 441.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "plasmacytoid DC: 194.6" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "CAPAN-2: 276.3;OE19: 558.9" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA010690, HPA010707" Enhanced Uncertain "Endoplasmic reticulum,Cytosol" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 22: Epithelial cell types - Mixed function" Cytosol "Endoplasmic reticulum" "HPA010690: , HPA010707: AB_1853922" "unprognostic (9.35e-2)" "unprognostic (6.13e-2)" "unprognostic (4.33e-2)" "prognostic favorable (5.26e-5)" "unprognostic (1.58e-1)" "unprognostic (8.26e-2)" "unprognostic (1.02e-2)" "unprognostic (1.18e-1)" "unprognostic (4.38e-2)" "unprognostic (2.77e-2)" "unprognostic (8.78e-2)" "unprognostic (6.41e-2)" "prognostic favorable (3.22e-9)" "unprognostic (4.10e-1)" "unprognostic (9.91e-2)" "unprognostic (1.77e-2)" "unprognostic (1.01e-2)" 61.8 92.7 43.5 30.4 42.9 42.6 66.6 45.1 60.6 63.6 54.8 112.5 132.5 39.2 82.1 177.6 70.8 87.6 118.3 42.6 45.7 99.2 393.2 49.0 36.0 46.6 44.6 26.3 66.2 102.0 44.6 75.6 46.5 74.9 121.2 7.8 90.6 50.0 104.2 97.1 143.5 57.4 46.6 60.5 72.5 50.6 45.3 35.1 45.8 118.4 64.6 86.7 78.4 48.9 40.8 58.5 28.7 0.3 4.8 15.4 17.7 7.2 66.1 3.2 10.7 62.3 276.3 0.1 158.2 17.5 13.6 74.8 52.7 81.2 4.9 22.3 47.7 174.9 57.3 251.5 13.3 152.7 130.0 53.0 197.2 2.1 12.5 63.9 166.3 0.3 75.9 25.7 23.3 33.9 0.2 24.7 6.5 558.9 59.4 12.7 33.4 54.0 153.0 87.4 71.9 21.6 53.2 83.2 64.8 2.0 52.9 202.2 104.9 5.6 27.3 7.8 6.4 29.7 22.5 9.7 3.8 254.8 12.6 43.8 103.8 30.4 4.1 64.8 2.9 1.3 7.6 3.5 147.0 2.4 2.3 2.6 17.7 26.4 22.2 194.6 37.7 39.4 43.5 42.9 45.1 60.6 42.6 45.7 46.6 44.6 46.5 46.6 45.3 48.9 327.9 25.6 36.6 5.5 7.7 61.1 295.9 316.7 75.7 7.8 99.1 57.3 100.5 205.9 185.5 95.6 25.0 85.3 71.0 168.3 90.1 121.0 6.3 132.5 27.1 238.4 121.8 60.2 19.4 138.6 62.8 31.8 90.2 172.9 43.2 56.9 203.1 419.3 378.1 6.7 24.2 215.1 170.9 107.8 77.8 12.8 44.4 85.3 39.2 49.6 83.6 14.1 27.8 11.6 4.7 121.8 213.1 33.4 7.1 94.6 441.1 277.2 126.6 3.5 13.1 44.6 49.6 4.6 15.1 264.0 124.9 67.2 15.2 43.6 258.2 344.9 MGST3 GST-III ENSG00000143198 "Microsomal glutathione S-transferase 3" O14880 1 165631213-165661796 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lyase, Oxidoreductase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 2092.0;Syncytiotrophoblasts: 2371.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 793.9;OE19: 781.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA053311, HPA077929" Enhanced Approved Nucleoplasm NA NA 27000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 47: Cytotrophoblasts - Unknown function" Nucleoplasm "HPA053311: AB_2682108, HPA077929: " "unprognostic (1.21e-1)" "unprognostic (1.44e-1)" "unprognostic (1.65e-2)" "unprognostic (1.22e-2)" "unprognostic (2.67e-1)" "unprognostic (7.78e-2)" "unprognostic (3.09e-1)" "unprognostic (2.06e-2)" "unprognostic (2.16e-1)" "unprognostic (1.90e-1)" "unprognostic (3.96e-1)" "unprognostic (3.34e-2)" "unprognostic (1.12e-2)" "unprognostic (7.60e-2)" "unprognostic (8.88e-2)" "unprognostic (1.89e-1)" "unprognostic (1.90e-1)" 260.2 163.3 218.0 57.7 224.9 126.2 196.5 245.4 273.1 96.6 214.1 219.6 358.6 91.9 520.6 97.6 112.3 114.4 770.2 232.6 258.0 254.3 166.8 117.5 48.9 239.5 228.8 118.0 90.1 139.1 86.1 173.2 248.3 113.4 217.8 89.9 164.0 114.8 568.0 87.8 301.6 118.8 227.4 54.4 163.0 64.2 230.3 51.9 142.9 578.7 47.7 107.2 90.0 240.5 178.2 128.0 150.0 106.1 533.4 312.1 653.1 158.1 244.2 119.1 205.2 126.8 219.1 10.9 117.1 198.6 117.8 204.7 36.2 155.2 118.5 793.9 94.5 27.1 84.7 60.4 144.9 45.0 58.9 284.2 107.5 178.0 62.3 239.4 202.0 54.2 72.3 65.6 233.6 37.0 48.9 97.4 292.3 781.6 165.8 44.8 63.0 22.2 599.8 159.4 104.1 134.2 148.7 181.1 313.2 308.4 139.1 215.9 174.7 135.8 82.6 92.9 110.8 49.7 37.0 5.8 239.8 109.7 92.3 44.8 172.9 81.2 107.2 150.2 107.9 79.3 130.5 117.3 138.0 78.2 81.4 89.1 32.3 62.3 195.0 58.2 125.5 185.0 218.0 224.9 245.4 273.1 232.6 258.0 239.5 228.8 248.3 227.4 230.3 240.5 915.1 102.5 164.8 48.3 87.6 228.3 251.8 603.8 111.0 144.6 177.0 267.6 670.1 301.7 292.6 557.3 266.9 2092.0 96.5 500.3 1001.8 380.2 18.2 325.6 132.6 268.0 152.8 785.4 75.8 425.9 1327.2 300.3 193.7 257.7 91.8 519.5 257.7 295.0 837.4 131.2 86.4 302.9 374.3 130.0 243.1 46.1 388.0 234.9 519.4 43.1 296.6 257.9 87.6 45.8 90.6 401.8 613.9 399.8 92.9 173.9 1004.1 1227.6 459.9 162.5 506.2 197.5 652.1 23.1 40.4 157.1 232.6 2371.4 123.1 288.6 440.7 237.6 MLYCD "hMCD, MCD" ENSG00000103150 "Malonyl-CoA decarboxylase" O95822 16 83899115-83951445 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" "Decarboxylase, Lyase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "tongue: 21.5" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 97.5;Cone photoreceptor cells: 125.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031625 Enhanced NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 6: T47d - Mammary gland" "Cluster 54: Cardiomyocytes - Muscle contraction" "HPA031625: AB_10602028" "unprognostic (6.23e-2)" "unprognostic (1.94e-1)" "unprognostic (9.07e-2)" "unprognostic (2.76e-2)" "unprognostic (1.89e-1)" "unprognostic (1.95e-1)" "unprognostic (1.26e-1)" "unprognostic (2.36e-2)" "unprognostic (1.28e-1)" "unprognostic (6.23e-2)" "unprognostic (1.84e-4)" "unprognostic (2.33e-1)" "prognostic favorable (2.61e-7)" "unprognostic (2.39e-1)" "unprognostic (3.19e-1)" "unprognostic (9.56e-2)" "unprognostic (1.51e-3)" 2.5 2.1 1.9 1.0 2.5 0.4 1.4 1.5 2.4 1.1 2.7 1.7 1.7 1.3 1.2 1.0 1.4 0.7 9.5 1.7 1.9 2.7 5.7 1.2 1.2 2.5 2.5 1.9 5.1 2.0 1.2 0.9 2.0 1.2 1.7 2.4 2.1 1.5 8.2 1.0 1.4 1.2 1.6 1.0 2.5 1.3 3.2 1.0 1.5 21.5 0.9 1.6 0.9 2.5 0.6 1.9 1.6 1.9 2.5 0.9 2.9 0.8 1.2 0.7 0.4 0.9 1.5 0.1 2.4 1.2 2.6 1.5 1.4 0.6 0.7 0.8 1.9 0.9 0.8 1.9 3.0 1.2 2.1 1.1 1.4 0.4 0.4 1.3 0.8 1.4 1.4 0.4 1.1 2.4 0.7 2.7 1.6 2.7 0.4 2.2 1.1 1.1 1.6 1.1 1.4 0.9 3.0 1.1 2.4 2.1 3.4 2.5 0.6 1.8 0.3 1.0 0.2 2.1 1.3 2.0 1.0 0.9 1.9 0.5 0.1 0.5 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.0 0.0 1.9 2.5 1.5 2.4 1.7 1.9 2.5 2.5 2.0 1.6 3.2 2.5 6.1 6.4 7.3 8.5 10.9 2.0 7.4 1.5 4.6 25.2 7.2 5.2 97.5 17.2 5.5 23.9 125.1 20.2 10.6 12.9 31.3 5.7 4.6 10.4 6.9 8.2 10.2 9.1 3.1 5.5 11.1 10.5 15.3 8.7 5.7 20.1 12.8 46.2 12.3 16.8 6.2 15.2 4.1 10.1 2.0 8.6 14.6 8.2 3.6 3.7 7.7 14.7 27.8 12.5 8.2 6.7 13.1 19.5 6.5 10.4 19.4 19.4 2.4 53.3 6.6 19.0 8.1 12.1 14.4 5.2 2.0 8.2 9.0 17.5 17.1 8.6 MOCS1 MOCOD ENSG00000124615 "Molybdenum cofactor synthesis 1" Q9NZB8 6 39899578-39934551 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Molybdenum cofactor biosynthesis" Lyase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 33.7;Hepatocytes: 36.2;Sertoli cells: 78.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CACO-2: 40.4;JURKAT: 51.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045783, HPA058177, HPA075505" Uncertain Enhanced Cytosol NA NA "Cluster 32: T-cells - Unknown function" "Cluster 15: Liver - Metabolism" "Cluster 39: CACO-2 - Unknown function" "Cluster 47: Cytotrophoblasts - Unknown function" Cytosol "HPA045783: AB_10960058, HPA058177: AB_2683629, HPA075505: AB_2686751" "unprognostic (1.22e-1)" "prognostic unfavorable (1.07e-5)" "unprognostic (3.26e-2)" "unprognostic (1.44e-1)" "unprognostic (9.03e-2)" "unprognostic (1.99e-1)" "unprognostic (2.61e-2)" "unprognostic (4.85e-2)" "unprognostic (3.14e-2)" "unprognostic (1.08e-1)" "prognostic favorable (6.07e-5)" "unprognostic (5.34e-3)" "unprognostic (1.21e-1)" "unprognostic (3.97e-3)" "unprognostic (2.78e-1)" "unprognostic (2.93e-1)" "unprognostic (6.21e-2)" 33.7 9.5 14.6 3.2 17.9 0.0 26.8 16.8 14.7 8.8 11.2 11.7 16.2 10.0 10.1 6.7 10.3 5.5 22.0 12.7 16.0 20.4 40.3 22.9 4.5 17.4 18.8 9.0 11.9 9.6 5.3 35.6 16.2 5.3 5.6 3.0 6.1 7.5 25.7 7.3 12.7 9.2 15.6 2.6 7.6 3.2 17.3 3.3 16.0 45.0 3.4 10.0 6.6 16.4 0.0 2.1 7.0 11.4 19.3 7.2 15.2 8.7 15.0 12.1 10.0 40.4 0.1 0.0 8.4 7.4 7.0 0.4 8.2 9.8 8.7 0.0 8.6 0.0 0.0 13.7 12.2 0.0 3.1 12.0 3.7 7.9 4.2 7.2 10.1 51.1 8.4 0.7 11.7 5.0 16.0 0.0 7.9 0.1 4.6 0.0 6.3 1.1 7.6 8.2 6.1 8.5 0.0 4.2 7.0 6.3 5.2 1.4 16.2 12.2 9.8 7.7 4.1 0.0 1.7 0.0 1.3 0.0 4.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.6 0.5 0.0 0.3 0.0 0.0 0.0 0.2 14.6 17.9 16.8 14.7 12.7 16.0 17.4 18.8 16.2 15.6 17.3 16.4 5.7 6.4 1.5 6.2 0.1 0.6 0.6 0.7 1.2 1.6 9.3 6.5 11.6 8.6 0.3 9.2 12.5 33.7 0.5 3.6 5.9 4.4 0.8 0.9 1.6 3.3 0.0 0.0 3.2 4.1 2.3 4.3 1.1 1.4 1.3 6.3 3.3 36.2 2.9 3.3 2.6 3.5 0.0 2.8 1.0 1.8 3.7 0.4 1.8 2.8 0.0 4.6 0.0 1.0 4.4 1.0 9.1 3.0 1.3 0.2 13.2 17.8 0.0 2.2 78.9 3.9 20.3 1.6 1.9 1.2 1.1 6.2 0.3 0.8 5.5 0.6 MVD MPD ENSG00000167508 "Mevalonate diphosphate decarboxylase" P53602 16 88651935-88663161 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Lyase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hepatocytes: 147.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041404, HPA048250" Uncertain Approved "Cell Junctions,Cytosol" NA NA 170000 "Cluster 15: NK-cells - Transcription" "Cluster 37: Intestine - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 15: Hepatocytes - Hemostasis" Cytosol "Cell Junctions" "HPA041404: AB_2677457, HPA048250: AB_2680329" "unprognostic (1.67e-1)" "unprognostic (3.05e-1)" "unprognostic (2.42e-1)" "prognostic favorable (2.17e-4)" "unprognostic (1.89e-1)" "unprognostic (9.56e-2)" "unprognostic (9.26e-3)" "unprognostic (8.33e-2)" "unprognostic (6.68e-2)" "unprognostic (5.47e-2)" "unprognostic (2.51e-1)" "unprognostic (6.22e-2)" "unprognostic (1.19e-3)" "unprognostic (4.12e-2)" "unprognostic (1.69e-1)" "unprognostic (2.11e-1)" "unprognostic (5.00e-2)" 20.3 51.1 24.2 15.7 27.5 7.0 16.4 26.2 37.5 30.5 19.3 32.3 35.1 20.3 2.2 77.8 13.5 4.9 22.8 24.7 27.8 28.8 78.8 31.0 12.3 32.4 27.8 19.6 25.3 8.3 18.9 6.3 39.3 23.5 4.2 3.4 25.1 6.5 27.2 52.3 26.6 5.7 24.0 24.6 31.5 42.3 24.7 7.0 21.1 8.3 6.8 17.6 36.9 25.6 50.6 34.2 52.4 33.1 18.1 38.7 29.5 25.1 26.0 17.7 14.6 86.1 119.7 24.4 39.8 15.7 63.7 72.8 25.0 133.1 4.9 15.7 38.3 17.8 18.2 127.0 35.9 11.6 11.8 30.9 24.6 46.6 13.5 8.7 18.0 58.0 51.7 13.1 10.2 115.9 39.3 56.6 61.5 17.7 31.3 40.2 15.0 62.3 49.8 33.0 52.2 17.9 62.0 13.3 18.5 11.4 67.8 51.3 39.0 14.7 29.8 27.2 14.2 34.9 17.6 83.2 17.9 55.7 25.7 5.6 12.6 2.4 26.8 13.7 20.4 16.1 18.0 17.9 15.0 22.6 13.2 16.6 1.8 28.3 15.4 28.0 20.4 15.4 24.2 27.5 26.2 37.5 24.7 27.8 32.4 27.8 39.3 24.0 24.7 25.6 17.2 25.6 48.2 22.2 21.5 15.2 12.9 106.3 4.0 27.2 26.5 14.1 16.7 21.5 56.9 20.2 6.2 20.2 79.6 117.5 25.4 30.8 61.6 17.7 10.0 15.8 32.9 26.5 23.4 62.3 29.2 15.5 41.8 26.5 16.5 27.4 20.7 147.2 38.6 23.5 17.0 75.3 32.6 25.5 21.6 96.2 8.1 20.3 21.4 6.5 32.2 16.5 55.6 11.1 14.5 30.0 79.4 9.1 46.3 20.1 47.1 22.6 21.5 18.1 6.6 7.0 20.7 50.8 13.0 13.8 21.6 48.8 36.3 35.5 65.2 20.6 NAXD "CARKD, FLJ10769, LP3298" ENSG00000213995 "NAD(P)HX dehydratase" Q8IW45 13 110615545-110639996 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" Lyase "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 34.8;Distal tubular cells: 39.2;Extravillous trophoblasts: 26.7;Granulosa cells: 27.6;Syncytiotrophoblasts: 30.9;Theca cells: 24.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA010551 Approved NA NA 390000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 35: Non-specific - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 7: Non-specific - Mitochondria" "HPA010551: AB_1848669" "unprognostic (1.24e-1)" "unprognostic (5.14e-2)" "unprognostic (1.79e-2)" "prognostic favorable (3.15e-4)" "unprognostic (1.78e-1)" "unprognostic (1.81e-1)" "unprognostic (3.48e-2)" "unprognostic (2.89e-1)" "unprognostic (3.20e-1)" "unprognostic (9.01e-2)" "unprognostic (1.94e-2)" "unprognostic (4.36e-3)" "prognostic favorable (4.63e-5)" "unprognostic (2.19e-2)" "unprognostic (1.27e-1)" "unprognostic (2.30e-1)" "unprognostic (1.62e-2)" 17.3 37.1 44.0 16.0 43.7 8.2 19.4 43.6 46.3 16.7 40.8 23.1 22.9 18.7 26.6 23.4 22.6 21.3 26.4 45.7 42.8 24.9 65.4 18.8 20.8 45.9 45.0 39.0 36.2 28.4 22.4 23.3 44.5 25.8 19.7 14.3 22.8 28.9 31.9 30.5 23.0 21.7 43.9 21.8 30.3 24.2 46.2 18.3 25.4 33.6 17.1 17.3 15.0 45.2 36.0 15.7 28.1 24.3 29.8 23.6 35.4 27.9 22.7 24.6 26.2 43.9 35.1 7.3 28.4 21.7 25.3 28.1 16.3 24.4 16.0 31.6 27.4 22.5 47.9 23.5 34.2 29.3 20.2 29.1 42.4 19.8 17.7 32.5 21.9 31.8 19.6 0.2 22.3 30.0 23.1 48.4 21.2 64.4 17.2 8.2 14.4 5.9 30.3 30.1 42.5 28.6 16.8 75.4 21.6 18.5 39.7 54.4 25.3 17.1 14.3 0.1 22.4 25.6 18.7 0.3 27.7 8.7 28.9 0.0 8.3 0.8 9.6 9.0 6.3 8.4 9.6 8.9 10.4 8.2 9.9 9.1 1.0 9.2 6.5 10.1 10.5 8.3 44.0 43.7 43.6 46.3 45.7 42.8 45.9 45.0 44.5 43.9 46.2 45.2 9.3 19.2 12.7 0.0 2.5 0.0 0.0 0.0 0.0 0.0 14.2 11.3 0.0 0.0 9.9 22.0 0.0 34.8 5.4 0.0 39.2 15.0 0.0 7.3 10.5 4.0 0.0 0.0 0.0 11.8 26.7 6.2 0.0 8.8 1.3 27.6 0.0 0.0 10.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 10.3 0.0 0.0 0.0 0.0 11.6 0.0 0.0 2.1 0.0 0.0 22.4 8.7 0.0 0.0 0.0 6.4 0.0 0.0 0.0 0.0 30.9 2.1 24.4 0.0 0.0 NEIL1 "FLJ22402, FPG1, hFPG1, NEI1" ENSG00000140398 "Nei like DNA glycosylase 1" Q96FI4 15 75346955-75357115 "Enzymes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair" "DNA-binding, Glycosidase, Hydrolase, Lyase, Multifunctional enzyme" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Granulosa cells: 105.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Group enriched" "Detected in many" 5 "gdT-cell: 5.2;memory B-cell: 4.8;naive B-cell: 6.4;NK-cell: 15.8" "Group enriched" "Detected in many" 11 "B-cells: 6.4;NK-cells: 15.8;T-cells: 5.2" "Cell line enhanced" "Detected in many" "Daudi: 11.5;HeLa: 11.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054084 Approved Supported Nucleoplasm NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 20: HeLa - Mitochondria" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "HPA054084: AB_2682372" "unprognostic (9.84e-3)" "unprognostic (1.19e-1)" "unprognostic (1.15e-2)" "unprognostic (4.62e-3)" "unprognostic (3.21e-2)" "unprognostic (1.81e-2)" "unprognostic (2.24e-2)" "unprognostic (1.17e-3)" "unprognostic (1.67e-1)" "unprognostic (1.33e-1)" "prognostic favorable (2.09e-4)" "unprognostic (3.50e-3)" "unprognostic (8.60e-2)" "unprognostic (9.24e-2)" "unprognostic (2.05e-1)" "unprognostic (3.03e-1)" "unprognostic (2.27e-3)" 8.0 14.6 2.0 3.1 3.1 4.3 11.6 6.2 5.0 14.7 2.0 9.3 5.8 10.0 1.7 7.3 12.9 3.9 5.8 2.2 1.7 8.8 12.8 8.3 6.1 1.4 0.4 13.3 10.9 3.3 11.0 2.5 0.7 12.4 1.1 2.6 16.6 4.1 9.0 8.9 8.3 1.9 0.0 8.8 10.5 3.7 1.1 2.7 10.7 0.6 3.0 8.2 10.9 2.2 2.2 3.6 2.3 1.4 0.7 0.8 4.5 1.3 0.0 0.5 0.1 0.6 4.0 11.5 2.1 0.2 1.1 6.1 1.4 0.4 0.0 5.7 9.1 2.0 11.8 1.7 0.9 2.1 2.6 0.3 1.7 0.6 0.0 5.6 1.4 1.1 1.4 3.3 0.3 2.9 0.4 6.3 2.1 0.4 0.8 2.1 1.5 0.5 2.1 2.4 1.4 2.8 2.2 1.0 3.2 1.2 4.2 3.5 6.3 1.3 2.3 1.8 1.2 5.2 5.5 9.7 1.1 9.4 1.2 0.0 0.6 0.0 5.2 0.3 1.3 4.8 0.9 1.2 0.2 6.4 1.4 1.4 0.8 15.8 0.2 0.3 0.3 1.4 2.0 3.1 6.2 5.0 2.2 1.7 1.4 0.4 0.7 0.0 1.1 2.2 15.9 22.4 19.2 19.9 33.7 6.4 15.4 10.1 23.3 20.0 22.1 15.9 2.9 10.0 21.9 14.7 10.4 10.8 19.1 13.6 1.9 9.0 20.4 31.8 7.3 16.9 21.6 8.0 33.5 8.3 3.6 7.7 22.4 15.4 11.4 105.6 24.3 11.5 3.4 10.1 29.9 20.0 10.2 5.7 7.0 2.6 19.0 3.3 8.8 8.4 1.7 14.6 55.6 5.5 4.5 7.3 16.0 13.5 9.1 9.2 21.4 8.9 41.9 6.5 6.6 6.6 6.4 1.6 1.5 11.0 5.8 4.8 10.0 2.0 14.5 8.7 NEIL2 "FLJ31644, MGC2832, MGC4505, NEH2" ENSG00000154328 "Nei like DNA glycosylase 2" Q969S2 8 11769639-11787345 "Enzymes, Predicted intracellular proteins" "DNA damage, DNA repair" "DNA-binding, Glycosidase, Hydrolase, Lyase, Multifunctional enzyme" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Spermatogonia: 68.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA073029, HPA073916" Supported Nucleoplasm,Vesicles NA NA "Cluster 30: Non-specific - Translation" "Cluster 35: Non-specific - Unknown function" "Cluster 17: WM-115 - Nervous system development" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" Nucleoplasm Vesicles "HPA073029: AB_2732216, HPA073916: AB_2732245" "unprognostic (1.52e-2)" "unprognostic (1.08e-2)" "unprognostic (1.03e-1)" "unprognostic (9.88e-2)" "unprognostic (2.18e-2)" "unprognostic (5.72e-2)" "unprognostic (2.70e-1)" "unprognostic (2.88e-2)" "unprognostic (5.46e-2)" "unprognostic (6.85e-2)" "unprognostic (1.99e-3)" "unprognostic (1.29e-1)" "unprognostic (1.12e-2)" "unprognostic (5.29e-2)" "unprognostic (1.91e-1)" "unprognostic (2.09e-1)" "unprognostic (4.05e-1)" 9.5 27.8 29.2 5.9 28.8 2.3 9.5 27.7 27.9 13.1 23.8 8.6 2.8 9.5 12.5 6.9 15.0 5.7 14.6 29.6 35.6 12.8 16.3 7.4 7.1 32.0 34.3 11.1 11.2 9.0 17.9 6.4 36.8 11.3 4.8 13.4 10.0 8.1 24.5 15.8 6.8 8.5 31.9 12.4 6.9 26.1 36.1 4.7 11.8 13.7 6.9 9.8 8.8 28.3 8.2 22.9 14.1 27.7 6.6 12.2 6.3 13.0 10.6 12.2 8.4 7.1 8.8 3.2 4.9 15.7 26.3 7.1 13.5 14.1 16.7 9.7 6.7 11.3 5.7 13.9 5.3 5.0 8.2 10.8 20.7 10.7 9.9 11.8 11.6 3.7 16.1 10.8 15.0 8.6 0.9 5.2 12.6 33.9 12.1 14.4 18.1 8.8 14.4 12.3 21.5 17.0 10.2 5.3 19.1 11.2 8.4 0.7 14.3 13.9 19.8 3.8 18.4 10.0 22.3 5.7 36.6 16.7 28.8 0.7 2.2 0.2 12.7 3.9 17.5 21.9 12.9 15.3 4.6 16.9 18.7 16.8 1.3 15.1 2.0 8.3 9.3 7.0 29.2 28.8 27.7 27.9 29.6 35.6 32.0 34.3 36.8 31.9 36.1 28.3 7.2 0.0 5.8 6.2 14.0 8.5 17.1 8.0 13.6 32.3 13.1 7.7 19.6 14.3 7.0 7.3 16.7 18.6 5.6 1.5 33.2 21.1 1.1 6.9 8.4 8.9 10.1 10.3 6.3 23.3 15.8 10.3 3.1 3.8 2.5 14.9 7.9 23.6 15.1 8.4 6.9 6.1 14.2 6.9 6.6 2.1 14.0 6.8 14.2 0.0 6.6 38.9 11.3 6.0 3.7 15.1 1.0 24.5 3.8 15.3 0.8 32.2 6.8 17.1 6.6 11.8 10.2 19.0 68.1 8.3 12.8 5.3 9.7 8.9 6.2 12.0 NEIL3 "FLJ10858, FPG2, hFPG2, hNEI3, ZGRF3" ENSG00000109674 "Nei like DNA glycosylase 3" Q8TAT5 4 177309874-177362936 "Enzymes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair" "DNA-binding, Glycosidase, Hydrolase, Lyase, Multifunctional enzyme" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "bone marrow: 6.6;lymphoid tissue: 23.6" "Cell type enhanced" "Detected in some" "Erythroid cells: 14.7;Granulosa cells: 4.8;Plasma cells: 6.1;Squamous epithelial cells: 4.5" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HDLM-2: 72.1;HL-60: 79.1;Karpas-707: 99.1;MOLT-4: 80.7" "Not detected" "Not detected" "Region enhanced" "Detected in some" "cerebellum: 3.3" HPA065761 Enhanced Nucleoplasm NA Yes "Cluster 48: NK-cells - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "HPA065761: AB_2685555" "unprognostic (6.03e-2)" "unprognostic (5.79e-2)" "unprognostic (1.42e-1)" "prognostic unfavorable (5.45e-4)" "unprognostic (4.91e-2)" "unprognostic (2.05e-1)" "unprognostic (3.64e-7)" "prognostic unfavorable (1.16e-4)" "unprognostic (6.09e-3)" "unprognostic (7.67e-2)" "unprognostic (6.51e-4)" "unprognostic (2.82e-3)" "unprognostic (0.00e+0)" "unprognostic (3.25e-2)" "unprognostic (8.13e-2)" "unprognostic (2.03e-1)" "unprognostic (1.04e-2)" 0.1 0.0 0.0 1.7 0.0 6.6 0.3 0.0 0.1 0.2 0.0 1.1 1.1 0.1 0.0 1.6 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.1 3.6 0.0 0.1 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.5 0.0 0.2 0.0 0.0 2.3 1.3 0.5 0.0 0.4 0.6 1.5 0.1 23.6 0.0 0.0 3.5 0.4 0.4 0.0 19.3 15.8 16.4 8.2 1.8 3.3 8.0 23.4 8.6 25.3 14.9 5.8 16.5 21.2 3.4 6.2 25.1 8.8 17.4 9.3 36.6 72.1 11.4 14.7 11.9 15.2 0.5 79.1 9.7 0.3 0.5 26.2 5.6 5.2 9.9 53.9 15.3 99.1 16.7 8.4 80.7 30.2 7.5 5.7 11.5 16.2 11.2 6.8 6.8 2.6 12.8 8.9 11.7 13.4 6.3 7.2 10.9 20.4 4.7 15.2 11.8 7.8 24.0 6.8 4.8 33.5 10.1 27.8 24.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.2 0.1 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.9 0.1 0.4 1.2 0.0 0.2 0.1 0.4 0.0 1.3 0.0 0.0 2.6 1.6 0.5 0.0 0.0 0.1 0.1 0.6 0.3 0.0 14.7 0.1 0.2 3.3 0.9 0.0 0.5 0.0 4.8 0.4 0.0 1.5 0.0 0.1 1.0 0.0 1.3 0.4 0.2 0.0 1.7 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.1 0.7 6.1 0.1 0.1 0.0 0.1 0.0 0.0 0.1 0.5 2.7 2.4 4.5 1.3 0.3 1.0 0.5 1.2 0.2 NPL "C1orf13, DHDPS1, NPL1" ENSG00000135838 "N-acetylneuraminate pyruvate lyase" Q9BXD5 1 182789293-182830384 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "kidney: 52.3;placenta: 45.2" "Cell type enhanced" "Detected in many" "Astrocytes: 170.1;Cytotrophoblasts: 123.1;Hofbauer cells: 481.5;Kupffer cells: 148.8;Microglial cells: 125.5;Proximal tubular cells: 141.0;Syncytiotrophoblasts: 107.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 423.2" "Group enriched" "Detected in many" 34 "granulocytes: 423.2;monocytes: 128.4" "Cell line enhanced" "Detected in many" "HEL: 14.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA028345, HPA075808" Enhanced Approved "Vesicles,Plasma membrane" NA NA 190000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 7: Kidney - Transmembrane transport" "Cluster 2: Karpas-707 - Immune response" "Cluster 4: Macrophages - Innate immune response" Vesicles "Plasma membrane" "HPA028345: AB_10610145, HPA075808: " "unprognostic (2.43e-2)" "unprognostic (5.71e-3)" "unprognostic (1.72e-2)" "unprognostic (1.06e-1)" "unprognostic (1.57e-1)" "unprognostic (3.06e-1)" "prognostic unfavorable (8.05e-4)" "unprognostic (4.41e-2)" "unprognostic (6.54e-3)" "unprognostic (1.45e-1)" "unprognostic (1.49e-1)" "unprognostic (6.18e-2)" "prognostic unfavorable (6.63e-4)" "unprognostic (2.11e-1)" "unprognostic (2.93e-2)" "unprognostic (2.35e-2)" "unprognostic (7.44e-2)" 12.7 5.8 16.7 19.2 20.8 18.9 5.5 19.3 22.9 4.3 11.1 6.9 2.8 1.7 29.9 10.0 3.3 13.0 2.6 12.7 15.6 52.3 20.8 14.5 32.5 19.6 20.1 1.4 2.8 3.3 1.7 45.2 18.9 2.3 9.1 1.9 4.2 6.2 1.7 8.4 4.4 7.5 15.8 28.7 5.0 5.1 27.0 6.2 2.6 2.8 14.7 15.5 5.1 22.0 3.4 0.6 1.0 0.0 2.8 2.8 0.9 1.1 2.1 1.2 0.6 0.0 1.4 9.0 1.5 0.0 0.0 1.3 1.9 2.4 0.3 0.0 1.5 14.2 0.4 0.1 1.5 5.4 8.1 2.2 9.1 0.2 0.0 0.1 0.1 10.1 10.9 13.8 2.1 1.1 0.3 3.5 11.0 7.0 1.1 1.4 0.7 11.0 0.2 7.4 3.1 4.6 5.0 0.3 4.7 1.1 2.9 8.7 0.2 1.1 2.4 0.7 0.1 9.8 12.7 9.0 2.4 9.5 3.6 25.5 128.4 104.1 5.5 118.2 4.8 1.8 4.5 4.9 7.6 6.3 3.5 4.9 423.2 0.3 96.6 1.5 8.1 65.4 16.7 20.8 19.3 22.9 12.7 15.6 19.6 20.1 18.9 15.8 27.0 22.0 2.9 0.0 5.5 170.1 4.9 6.1 4.0 8.6 1.8 7.6 1.5 4.4 2.9 2.8 4.8 7.3 2.1 123.1 2.2 2.3 19.6 1.2 19.1 0.4 0.6 3.5 1.8 45.5 7.5 2.4 6.1 2.5 3.1 0.2 5.7 0.5 72.8 3.9 481.5 6.7 13.5 1.4 6.1 148.8 11.5 27.0 0.9 91.7 10.6 125.5 40.1 2.8 5.2 22.1 21.0 1.3 0.3 0.4 0.7 1.6 0.9 141.0 1.7 2.8 0.0 1.7 1.7 16.5 8.9 16.5 7.1 107.4 3.1 3.4 1.6 4.3 NPR1 "ANPa, ANPRA, GUCY2A, NPRA" ENSG00000169418 "Natriuretic peptide receptor 1" P16066 1 153678688-153693992 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted membrane proteins, Transporters" "cGMP biosynthesis" "Lyase, Receptor, Vasoactive" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 67.1" "Group enriched" "Detected in many" 6 "Adipocytes: 99.6;Endothelial cells: 52.5;Hepatic stellate cells: 132.8" "Group enriched" "Detected in all" 4 "ovarian cancer: 39.2;renal cancer: 12.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 6 "ASC diff: 158.5" "Region enriched" "Detected in all" 5 "olfactory bulb: 18.7" "Low region specificity" "Detected in many" HPA031087 Approved "Nucleoplasm,Nucleoli,Plasma membrane" NA NA "Cluster 82: Adipose tissue - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Nucleoli "Nucleoplasm, Plasma membrane" "HPA031087: AB_10601975" "unprognostic (2.54e-1)" "unprognostic (3.03e-3)" "unprognostic (6.31e-2)" "prognostic unfavorable (3.97e-4)" "unprognostic (1.55e-1)" "unprognostic (6.60e-2)" "unprognostic (1.54e-2)" "unprognostic (2.03e-1)" "unprognostic (2.46e-1)" "unprognostic (3.27e-2)" "prognostic favorable (2.49e-4)" "unprognostic (1.27e-1)" "unprognostic (6.69e-2)" "unprognostic (1.16e-2)" "unprognostic (1.09e-1)" "unprognostic (4.06e-1)" "unprognostic (1.74e-2)" 67.1 8.7 1.7 3.4 1.5 0.0 44.3 1.4 1.4 8.8 1.5 10.1 1.5 31.0 5.5 4.3 36.4 5.9 15.8 1.3 1.4 28.8 4.3 24.2 2.3 1.5 1.5 27.7 3.9 8.4 3.8 17.7 1.5 4.4 2.0 0.1 3.7 12.1 7.2 6.6 9.3 9.7 1.8 2.2 8.8 1.3 2.4 1.9 14.0 11.1 1.3 12.8 9.7 1.4 0.0 1.3 0.1 0.0 158.5 0.6 0.1 0.0 0.0 0.1 0.1 0.1 0.6 0.0 0.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 28.0 0.0 19.0 0.0 0.0 0.3 0.0 0.3 0.0 0.1 3.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.8 0.0 0.0 15.9 0.0 0.0 2.1 0.0 0.1 0.0 1.9 0.0 5.7 1.0 0.1 0.0 0.2 0.0 0.0 8.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 1.5 1.4 1.4 1.3 1.4 1.5 1.5 1.5 1.8 2.4 1.4 99.6 0.0 6.9 0.0 0.2 1.5 0.5 0.0 0.6 0.0 0.5 0.5 4.5 2.8 0.0 14.7 0.0 0.2 0.1 0.0 0.0 0.7 9.1 6.2 8.8 52.5 0.0 0.0 0.0 0.0 1.3 15.2 0.0 15.4 0.0 0.0 132.8 2.4 0.3 0.0 0.0 0.0 0.0 4.7 4.0 11.5 10.2 0.5 0.0 0.0 5.2 0.0 0.0 0.0 0.0 1.0 0.0 4.1 0.0 0.5 0.0 4.0 0.0 0.0 0.0 1.4 2.2 0.5 0.1 0.2 1.0 0.7 0.3 1.4 0.2 0.0 NPR2 "AMDM, ANPb, ANPRB, GUCY2B, NPRB" ENSG00000159899 "Natriuretic peptide receptor 2" P20594 9 35791591-35809732 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "cGMP biosynthesis, Osteogenesis" "Lyase, Receptor" "Disease variant, Dwarfism, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 35.6;Excitatory neurons: 69.1;Inhibitory neurons: 68.9;Microglial cells: 34.7;Oligodendrocyte precursor cells: 51.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 30.9;ASC TERT1: 21.1;BJ hTERT+: 20.2;HHSteC: 20.1;HSkMC: 23.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 35: Non-specific - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (2.93e-2)" "unprognostic (8.22e-3)" "unprognostic (9.25e-3)" "unprognostic (3.59e-2)" "unprognostic (6.13e-2)" "unprognostic (2.63e-2)" "unprognostic (1.41e-1)" "unprognostic (1.56e-1)" "unprognostic (1.56e-1)" "unprognostic (2.40e-1)" "unprognostic (3.06e-1)" "unprognostic (1.49e-1)" "unprognostic (3.99e-2)" "unprognostic (6.99e-3)" "unprognostic (7.10e-2)" "unprognostic (3.24e-1)" "unprognostic (7.86e-2)" 12.4 8.2 9.3 1.7 9.4 0.3 10.3 14.4 9.9 25.7 7.7 15.6 1.8 20.5 8.7 3.2 15.1 3.2 12.8 9.1 11.4 6.7 8.6 9.1 2.3 11.8 9.4 9.4 3.2 1.3 13.8 4.7 11.5 10.9 2.8 4.1 5.3 6.5 10.8 8.3 7.5 9.9 8.2 4.9 7.8 4.8 10.7 2.2 6.0 8.6 1.7 12.1 14.7 7.9 0.0 2.9 2.2 0.0 30.9 21.1 1.9 9.3 20.2 7.0 6.4 4.5 4.3 1.8 3.0 17.9 12.8 1.2 3.6 0.2 6.1 2.2 1.0 1.8 4.3 3.4 20.1 0.4 0.0 23.8 1.8 8.9 0.6 7.6 12.7 2.5 0.7 0.2 13.4 1.0 0.5 0.8 3.5 1.0 3.7 2.4 0.2 0.5 1.8 1.4 1.1 0.7 0.4 0.1 0.6 3.8 0.2 0.0 8.2 8.5 7.8 3.2 1.2 0.5 0.6 4.8 10.4 0.6 5.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.3 0.0 9.3 9.4 14.4 9.9 9.1 11.4 11.8 9.4 11.5 8.2 10.7 7.9 2.7 3.2 3.4 35.6 0.0 1.1 0.6 0.6 1.2 5.1 0.7 1.4 0.7 1.5 0.3 0.0 2.1 0.4 0.5 0.7 0.0 0.6 0.3 1.4 9.2 4.4 0.0 0.0 69.1 0.8 0.2 7.2 0.5 2.0 1.3 9.6 6.1 4.5 0.4 3.3 68.9 0.7 0.0 0.3 2.1 0.3 9.3 0.3 0.0 34.7 0.0 6.8 0.0 51.8 16.3 0.6 3.6 7.9 0.2 2.7 0.2 0.6 1.1 2.2 0.0 5.1 3.4 4.5 3.1 0.1 1.6 0.3 0.7 0.8 1.1 0.4 NTHL1 "NTH1, OCTS3" ENSG00000065057 "Nth like DNA glycosylase 1" P78549 16 2039815-2047866 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair" "Glycosidase, Hydrolase, Lyase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in many" 10 "Hepatocytes: 866.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB025152 Supported NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 35: Non-specific - Unknown function" "Cluster 25: RPMI-8226 - Immune response" "Cluster 2: Hepatocytes - Metabolism" "CAB025152: " "unprognostic (1.06e-1)" "unprognostic (9.71e-2)" "unprognostic (1.23e-1)" "unprognostic (2.54e-1)" "unprognostic (7.89e-2)" "unprognostic (1.77e-1)" "unprognostic (2.86e-1)" "unprognostic (2.46e-2)" "unprognostic (4.98e-2)" "unprognostic (1.11e-1)" "unprognostic (2.77e-2)" "unprognostic (6.78e-2)" "unprognostic (6.53e-2)" "unprognostic (2.27e-1)" "unprognostic (1.34e-1)" "unprognostic (5.08e-2)" "unprognostic (1.62e-2)" 11.7 9.3 13.8 6.2 14.7 4.7 11.0 14.8 19.7 15.5 11.1 16.8 6.6 15.4 3.1 11.3 13.8 6.0 15.8 13.5 14.2 9.8 21.9 10.7 8.4 15.4 13.9 16.1 9.9 4.8 11.5 5.6 15.6 11.2 5.6 1.8 16.0 11.5 9.7 9.3 11.1 5.3 13.6 16.7 13.2 8.7 15.2 7.6 9.6 6.8 5.9 11.8 12.5 14.2 29.8 74.2 20.8 32.2 8.5 15.9 22.8 12.1 13.2 23.1 14.6 53.0 28.8 63.0 25.2 10.7 15.1 26.2 26.1 29.0 4.0 28.9 63.3 19.5 47.7 60.9 11.5 22.4 22.3 13.2 14.9 12.3 13.2 15.4 33.4 37.0 22.2 22.6 9.0 34.9 33.9 88.3 46.2 37.3 47.3 80.8 22.0 103.5 17.2 10.7 43.9 43.5 13.2 41.0 25.4 7.6 29.6 23.5 12.9 19.9 21.5 17.5 23.1 30.3 38.0 26.9 8.8 31.7 24.9 4.2 15.0 3.4 14.4 26.0 16.2 37.5 17.3 16.7 25.7 32.8 12.8 15.4 0.7 19.1 22.5 26.3 34.0 14.4 13.8 14.7 14.8 19.7 13.5 14.2 15.4 13.9 15.6 13.6 15.2 14.2 47.2 28.9 27.5 2.9 12.9 8.7 16.4 21.6 8.0 8.8 18.9 23.4 14.1 44.3 28.3 3.7 0.0 10.5 8.1 75.6 17.6 16.3 8.1 20.4 19.5 36.5 67.4 26.7 3.0 9.1 18.3 17.6 16.3 23.3 5.7 20.5 51.0 866.4 13.4 6.7 3.6 85.3 54.9 25.5 17.6 23.8 33.8 9.3 21.4 2.8 9.7 10.7 18.6 3.0 4.9 12.1 81.6 25.2 16.0 6.4 12.8 28.8 23.5 8.1 13.1 8.1 23.6 5.4 32.0 11.7 10.1 2.7 12.2 20.6 56.8 21.0 ODC1 ODC ENSG00000115758 "Ornithine decarboxylase 1" P11926 2 10439968-10448327 "Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Polyamine biosynthesis" "Decarboxylase, Lyase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 560.8;Late spermatids: 834.9;Prostatic glandular cells: 412.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001536, CAB035996" Approved Approved "Plasma membrane,Cytosol" NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 51: Myeloid cells - Hemostasis" "Plasma membrane, Cytosol" "CAB035996: , HPA001536: AB_1079521" "unprognostic (2.33e-1)" "unprognostic (3.41e-1)" "unprognostic (7.25e-3)" "unprognostic (5.21e-3)" "unprognostic (4.22e-2)" "unprognostic (2.70e-1)" "prognostic unfavorable (3.07e-5)" "unprognostic (3.06e-2)" "unprognostic (4.18e-2)" "unprognostic (6.27e-2)" "unprognostic (3.04e-1)" "unprognostic (6.65e-2)" "unprognostic (1.67e-3)" "unprognostic (1.18e-1)" "unprognostic (1.05e-1)" "unprognostic (2.26e-2)" "unprognostic (5.86e-2)" 47.2 23.2 31.0 69.3 31.5 172.9 33.0 30.5 32.2 33.5 48.5 64.8 32.4 66.0 49.2 29.4 56.3 43.7 55.9 29.9 33.0 132.2 92.1 52.4 111.0 32.4 33.0 54.8 61.8 99.6 92.5 20.0 30.6 91.1 72.0 46.2 27.0 55.1 163.3 29.2 41.6 71.2 34.1 42.9 51.5 133.3 34.0 77.1 58.5 73.5 149.1 113.6 26.9 35.7 166.8 130.6 177.1 211.4 31.1 92.4 410.1 234.6 114.9 216.3 99.9 697.3 75.4 870.2 114.6 143.6 208.6 30.2 549.1 265.5 261.2 334.0 231.5 398.1 212.2 429.9 250.8 680.1 91.8 62.5 70.5 490.1 608.3 111.4 176.3 237.6 674.2 274.3 121.7 109.0 680.1 267.3 324.9 228.3 418.8 478.5 556.0 586.3 130.9 119.5 246.6 209.9 293.6 88.8 121.8 135.7 60.0 300.5 124.7 174.4 362.6 227.9 511.7 128.0 416.1 780.8 156.7 443.6 109.9 0.0 1.5 3.0 2.9 2.9 3.3 14.8 4.1 4.8 3.4 15.0 2.8 4.5 0.5 1.4 1.8 12.2 4.4 3.2 31.0 31.5 30.5 32.2 29.9 33.0 32.4 33.0 30.6 34.1 34.0 35.7 78.2 44.8 161.4 7.5 228.9 58.0 123.7 48.8 19.4 36.8 53.2 68.3 55.1 81.5 33.9 40.5 31.3 1.5 188.1 77.7 72.4 50.6 560.8 90.9 66.2 52.2 271.0 111.3 7.5 27.6 70.0 63.2 204.4 127.6 58.9 103.8 14.6 50.3 46.8 6.7 4.1 234.1 22.4 32.1 22.4 834.9 15.5 191.8 23.2 8.4 22.1 126.3 37.0 4.5 2.4 28.6 64.5 11.3 287.4 412.4 31.6 154.1 21.9 77.4 0.0 223.0 79.9 186.5 75.8 52.2 87.5 3.4 133.0 30.2 180.5 142.2 OGG1 "HMMH, HOGG1, MUTM, OGH1" ENSG00000114026 "8-oxoguanine DNA glycosylase" O15527 3 9749944-9788219 "Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair" "Glycosidase, Hydrolase, Lyase, Multifunctional enzyme" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Proximal tubular cells: 86.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027514, CAB047301" Approved Enhanced Nucleoplasm NA NA "Cluster 15: NK-cells - Transcription" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "CAB047301: , HPA027514: AB_10602189" "unprognostic (6.95e-2)" "unprognostic (7.82e-3)" "unprognostic (7.19e-2)" "unprognostic (1.24e-3)" "unprognostic (9.69e-2)" "unprognostic (1.97e-2)" "prognostic unfavorable (5.77e-5)" "unprognostic (7.83e-2)" "unprognostic (2.45e-2)" "unprognostic (3.43e-3)" "unprognostic (9.66e-3)" "unprognostic (4.23e-2)" "prognostic favorable (2.65e-4)" "unprognostic (2.06e-2)" "unprognostic (2.24e-1)" "unprognostic (1.65e-1)" "unprognostic (1.59e-1)" 12.6 13.8 18.6 13.2 18.3 12.2 12.8 20.5 19.6 18.2 12.5 14.8 18.9 17.1 10.3 9.6 16.9 8.4 11.8 19.6 15.8 30.3 20.7 10.7 26.2 18.8 16.7 22.5 10.6 6.6 10.8 8.6 17.9 15.7 8.1 12.1 12.2 10.1 7.2 9.6 17.2 9.8 16.2 15.2 12.4 8.6 17.5 13.5 13.1 8.0 21.2 15.3 14.3 17.4 11.3 20.7 20.3 13.1 19.9 22.3 38.4 14.5 14.8 21.6 25.6 19.9 10.8 68.5 9.5 18.3 34.1 10.8 12.1 15.9 9.0 25.1 17.6 33.9 32.5 29.3 20.7 13.3 20.9 22.3 20.0 37.4 16.0 17.4 27.3 9.6 11.0 10.9 20.9 21.3 10.7 13.2 11.0 10.3 29.3 7.8 13.7 22.4 12.4 5.7 9.0 15.9 18.4 15.2 11.5 10.4 23.7 22.9 17.5 21.9 22.7 17.2 24.0 10.7 16.9 35.9 17.4 37.9 13.7 15.1 10.9 20.7 18.7 9.0 18.4 13.9 15.8 15.3 9.8 16.5 12.1 11.5 2.9 27.0 7.3 15.9 21.0 10.9 18.6 18.3 20.5 19.6 19.6 15.8 18.8 16.7 17.9 16.2 17.5 17.4 9.5 0.0 3.4 15.3 16.7 5.5 8.9 8.3 9.1 20.9 6.7 7.4 2.3 10.0 4.9 9.2 35.5 6.4 16.5 9.0 11.7 7.7 0.9 5.0 12.2 10.4 18.0 22.3 11.2 6.7 10.1 11.7 6.1 4.4 2.5 10.0 10.0 11.8 18.0 8.4 9.2 8.8 6.1 9.0 5.8 1.8 14.3 9.3 7.2 10.3 15.8 11.3 27.8 13.0 9.9 8.8 11.0 13.5 10.0 5.2 47.1 86.3 4.1 34.7 26.3 11.1 10.3 10.2 21.5 5.0 4.5 4.0 12.9 12.0 14.0 5.4 PAICS "ADE2H1, AIRC, PAIS" ENSG00000128050 "Phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase" P22234 4 56435741-56464578 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Purine biosynthesis" "Decarboxylase, Ligase, Lyase, Multifunctional enzyme" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 157.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035895, HPA041538" Approved Approved Cytosol Yes No 490000 "Cluster 30: Non-specific - Translation" "Cluster 3: T-cells - Adaptive immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Cytosol "HPA035895: AB_10669660, HPA041538: AB_2677540" "unprognostic (2.59e-3)" "unprognostic (7.90e-3)" "unprognostic (3.84e-3)" "unprognostic (2.88e-2)" "unprognostic (9.85e-2)" "unprognostic (2.82e-3)" "prognostic unfavorable (1.50e-4)" "unprognostic (8.07e-3)" "unprognostic (1.23e-2)" "prognostic favorable (8.44e-4)" "unprognostic (1.48e-3)" "unprognostic (2.05e-1)" "prognostic unfavorable (5.85e-5)" "unprognostic (7.11e-2)" "unprognostic (1.67e-1)" "prognostic unfavorable (2.41e-4)" "unprognostic (2.16e-1)" 24.5 40.2 22.7 40.1 26.7 46.8 54.6 28.3 25.0 29.3 21.6 42.8 32.1 29.7 22.1 36.3 35.4 17.8 19.7 20.3 27.8 42.7 109.7 14.1 51.3 26.0 30.1 30.7 21.7 39.5 17.7 45.9 26.1 31.0 54.7 30.4 26.4 25.8 32.4 37.6 30.8 35.7 25.6 18.3 20.7 29.5 26.8 56.4 32.4 24.1 64.5 37.4 25.4 27.2 239.3 175.3 354.3 220.6 74.3 166.1 304.0 201.7 145.1 282.5 276.0 280.5 275.7 548.0 228.3 136.0 154.1 143.6 565.5 293.0 480.8 110.4 198.8 298.7 259.5 313.4 141.8 537.1 127.6 141.9 207.9 301.0 225.0 155.7 235.4 308.6 524.7 198.5 246.8 159.3 621.5 267.2 407.5 454.8 216.5 496.2 151.7 361.5 268.4 164.5 378.8 226.4 198.6 273.7 124.3 287.2 181.2 169.8 127.7 222.6 290.1 221.8 419.0 139.1 128.2 571.1 234.8 385.2 251.0 6.0 5.2 0.4 5.2 8.7 15.0 17.8 14.4 9.2 15.3 11.0 17.4 15.5 1.1 15.9 6.9 17.0 11.2 8.7 22.7 26.7 28.3 25.0 20.3 27.8 26.0 30.1 26.1 25.6 26.8 27.2 16.4 22.4 22.9 17.0 35.7 56.6 71.9 66.0 54.1 27.4 35.8 37.5 23.3 50.1 32.3 33.1 6.2 134.4 15.3 20.5 37.2 45.0 69.4 15.2 49.1 25.1 24.7 80.8 9.1 26.3 157.5 34.2 15.3 23.3 21.0 69.1 13.2 78.7 51.5 28.6 14.6 41.0 34.6 16.1 17.2 10.6 29.8 16.1 17.8 6.5 20.2 14.0 6.2 13.0 12.2 27.4 18.6 23.3 48.1 81.7 15.9 47.7 17.9 24.6 0.0 31.3 29.2 40.0 50.3 53.1 50.4 54.6 16.8 66.4 69.7 48.9 PAM "PAL, PHM" ENSG00000145730 "Peptidylglycine alpha-amidating monooxygenase" P19021 5 102753981-103031105 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Lyase, Monooxygenase, Multifunctional enzyme, Oxidoreductase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 1560.4" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 1406.5;Enteroendocrine cells: 321.4;Inhibitory neurons: 487.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "ASC diff: 529.9;fHDF/TERT166: 714.5;hTERT-RPE1: 562.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB026119, HPA042260" Enhanced Approved "Golgi apparatus,Cytosol" "Secreted in other tissues" NA NA 98000000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 54: Cardiomyocytes - Muscle contraction" "Golgi apparatus, Cytosol" "CAB026119: , HPA042260: AB_2677919" "unprognostic (4.30e-3)" "unprognostic (1.60e-2)" "unprognostic (1.12e-1)" "prognostic favorable (1.63e-4)" "unprognostic (4.23e-2)" "unprognostic (6.30e-2)" "prognostic unfavorable (6.20e-4)" "unprognostic (7.58e-2)" "unprognostic (6.62e-2)" "unprognostic (2.71e-1)" "unprognostic (9.91e-2)" "unprognostic (3.18e-1)" "unprognostic (1.86e-2)" "unprognostic (1.08e-1)" "unprognostic (9.79e-2)" "unprognostic (5.51e-2)" "unprognostic (8.80e-3)" 119.3 202.5 71.6 34.6 81.4 10.1 99.0 50.7 82.5 595.0 96.2 125.1 52.6 140.9 678.2 69.4 87.6 97.3 1560.4 75.2 179.9 116.0 20.1 88.3 27.7 86.5 99.8 136.4 104.4 257.8 137.0 60.0 170.9 91.6 80.4 37.6 205.4 236.5 155.3 66.9 52.1 157.9 55.7 52.5 131.6 22.4 106.0 17.9 95.1 159.4 30.5 103.3 116.1 50.0 111.3 16.3 195.9 87.2 529.9 314.8 78.0 307.6 457.0 89.1 268.9 53.5 143.2 0.1 65.0 714.5 125.7 36.8 11.0 135.3 244.0 13.5 44.7 22.9 60.0 17.7 80.3 7.4 23.9 173.4 57.3 65.6 49.2 562.6 186.8 8.9 0.9 15.0 255.6 22.9 0.1 3.2 35.3 19.7 59.3 8.5 108.9 62.4 346.1 13.0 92.3 63.9 131.2 8.3 83.3 114.0 34.0 7.3 144.9 280.8 72.4 133.3 93.4 33.1 8.6 0.4 322.3 30.8 247.6 4.2 8.0 0.2 20.7 1.5 14.9 0.8 12.3 15.6 3.1 0.4 4.1 6.8 16.6 26.3 3.4 1.6 19.9 10.8 71.6 81.4 50.7 82.5 75.2 179.9 86.5 99.8 170.9 55.7 106.0 50.0 45.7 54.5 39.3 47.0 3.9 28.2 12.0 26.1 12.0 19.1 27.5 12.1 1406.5 0.0 30.4 60.7 2.1 1.6 12.6 13.7 7.9 12.6 8.8 47.6 48.6 63.5 321.4 3.4 229.2 21.5 40.6 220.4 26.0 83.0 9.5 68.3 74.6 3.5 5.9 8.4 487.7 13.8 18.3 10.3 48.3 8.1 60.3 9.3 37.4 192.0 9.5 11.6 22.6 154.8 9.3 30.6 6.3 58.6 12.1 26.4 4.8 43.8 19.2 3.8 19.7 36.4 44.9 2.6 5.6 8.0 23.7 6.7 16.6 19.3 6.3 18.2 PCBD1 "DCOH, PCBD, PCD" ENSG00000166228 "Pterin-4 alpha-carbinolamine dehydratase 1" P61457 10 70882280-70888565 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Tetrahydrobiopterin biosynthesis, Transcription, Transcription regulation" "Activator, Lyase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 429.5" "Cell type enhanced" "Detected in all" "Distal tubular cells: 453.9;Hepatocytes: 603.7;Proximal tubular cells: 877.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "CACO-2: 527.8;Hep G2: 527.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037575, HPA061723" Enhanced Enhanced Nucleoplasm,Cytosol NA NA 170000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 15: Liver - Metabolism" "Cluster 39: CACO-2 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm Cytosol "HPA037575: AB_10671761, HPA061723: AB_2684594" "unprognostic (1.02e-1)" "unprognostic (5.05e-2)" "unprognostic (7.43e-2)" "unprognostic (3.69e-1)" "unprognostic (5.39e-2)" "unprognostic (4.80e-3)" "unprognostic (1.81e-1)" "unprognostic (1.47e-1)" "unprognostic (2.35e-1)" "unprognostic (2.40e-2)" "unprognostic (2.95e-1)" "unprognostic (5.63e-2)" "unprognostic (3.38e-2)" "unprognostic (9.26e-2)" "unprognostic (1.74e-1)" "unprognostic (5.76e-2)" "unprognostic (7.43e-3)" 77.3 102.9 115.0 31.0 111.8 21.8 67.9 111.9 140.7 58.0 114.1 83.9 54.4 48.2 91.2 54.3 111.5 47.4 152.3 109.3 136.9 165.1 429.5 57.9 31.1 125.4 138.5 64.2 174.9 135.1 61.5 33.4 139.4 73.8 88.3 48.6 49.9 78.4 109.7 25.7 64.0 75.6 119.7 25.6 84.8 20.0 131.8 25.8 86.3 109.1 35.8 69.3 39.2 118.9 158.3 374.3 21.4 223.8 80.9 76.0 29.4 50.0 84.5 77.7 61.6 527.8 270.3 32.2 141.4 56.3 57.9 101.7 138.9 81.3 53.2 86.2 251.9 28.6 57.5 527.1 84.9 28.5 99.2 74.1 88.5 76.5 35.8 114.1 212.3 19.9 57.1 2.8 55.2 270.2 3.5 94.7 30.1 420.5 346.0 15.1 29.7 103.6 328.6 164.7 94.0 158.8 41.5 277.1 111.5 59.9 81.1 53.8 86.2 12.7 102.9 18.9 123.8 1.1 6.7 1.1 68.3 93.1 19.5 0.2 24.8 8.7 19.6 47.1 15.3 25.7 25.8 28.3 49.6 10.9 8.4 17.1 1.6 19.6 34.4 35.8 41.1 18.7 115.0 111.8 111.9 140.7 109.3 136.9 125.4 138.5 139.4 119.7 131.8 118.9 25.5 41.7 91.5 8.5 25.9 49.8 169.1 88.2 103.0 39.0 197.9 249.6 151.5 138.7 86.0 187.6 6.2 124.6 18.5 113.8 453.9 185.0 2.3 138.7 49.3 40.8 176.4 36.2 4.9 169.9 81.6 82.2 86.6 175.3 31.1 64.6 37.9 603.7 180.3 35.3 8.5 313.3 65.1 79.9 55.7 11.2 67.4 73.1 78.2 5.6 68.0 153.0 22.6 9.0 4.6 154.8 164.7 95.5 35.1 212.7 232.1 877.7 78.4 33.2 85.5 57.2 63.3 4.4 12.3 147.8 45.7 77.6 32.6 95.9 230.2 187.5 PCBD2 "DCOH2, DCOHM" ENSG00000132570 "Pterin-4 alpha-carbinolamine dehydratase 2" Q9H0N5 5 134905120-135007959 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Tetrahydrobiopterin biosynthesis" Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 49.4;tongue: 42.7" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036428 Uncertain Approved "Plasma membrane" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 6: T47d - Mammary gland" "Cluster 39: Non-specific - Basic cellular processes" "Plasma membrane" "HPA036428: AB_10670103" "unprognostic (3.70e-2)" "unprognostic (3.53e-2)" "unprognostic (3.54e-3)" "unprognostic (1.36e-2)" "unprognostic (2.92e-1)" "unprognostic (1.98e-1)" "unprognostic (4.22e-1)" "unprognostic (6.43e-2)" "unprognostic (4.49e-1)" "unprognostic (1.01e-1)" "unprognostic (1.22e-1)" "unprognostic (5.18e-2)" "unprognostic (1.87e-3)" "unprognostic (4.57e-2)" "unprognostic (6.34e-2)" "unprognostic (9.32e-3)" "unprognostic (1.50e-1)" 5.3 7.7 7.3 4.8 8.5 7.6 6.0 7.8 7.6 4.3 11.0 6.1 9.5 4.2 4.1 8.3 5.7 4.6 17.1 6.4 7.5 10.2 11.9 4.9 5.9 8.7 7.7 5.1 8.0 13.0 3.8 3.5 8.0 5.4 7.0 9.9 9.6 3.8 49.4 9.2 8.1 3.6 6.8 5.8 8.2 3.2 8.1 5.5 9.6 42.7 6.1 4.5 4.9 10.8 7.5 7.2 9.4 6.9 5.7 5.2 5.2 6.0 5.2 3.8 3.8 12.0 17.5 8.7 8.8 4.4 6.1 6.5 5.6 5.9 3.4 12.3 3.1 6.0 9.5 7.1 5.4 7.1 3.6 3.4 7.1 3.6 7.6 5.1 4.3 7.7 7.7 12.2 6.9 13.0 7.5 12.3 5.1 11.5 6.9 10.9 8.4 9.7 8.1 7.4 7.2 9.2 10.4 6.0 9.1 7.1 13.0 9.4 5.9 6.4 4.3 7.1 8.1 10.6 15.7 5.5 7.8 8.8 4.8 5.7 5.1 5.4 3.6 4.5 2.9 4.5 4.0 3.4 4.4 4.2 3.8 4.3 2.8 4.0 4.6 7.7 3.9 2.7 7.3 8.5 7.8 7.6 6.4 7.5 8.7 7.7 8.0 6.8 8.1 10.8 4.2 9.6 10.3 28.7 8.8 3.6 6.4 15.8 7.4 13.5 11.7 8.4 32.5 20.0 12.5 16.5 12.5 13.6 10.1 13.6 21.5 17.1 8.4 7.9 6.1 6.9 4.2 31.5 10.6 18.2 24.4 5.8 13.3 8.7 6.3 22.4 7.1 23.1 24.6 23.5 12.9 9.5 20.3 10.0 9.6 3.5 7.2 10.2 5.4 17.8 26.9 14.8 7.2 13.0 20.6 17.8 6.2 2.2 13.1 7.1 26.5 26.3 11.9 45.9 0.0 9.0 7.4 5.2 11.5 13.8 6.0 10.1 7.8 9.5 15.9 8.7 PCK1 PEPCK-C ENSG00000124253 "Phosphoenolpyruvate carboxykinase 1" P35558 20 57561080-57568121 "Citric acid cycle related proteins, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Gluconeogenesis "Decarboxylase, Kinase, Lyase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 432.1;liver: 681.4" "Cell type enhanced" "Detected in many" "Distal enterocytes: 703.8;Distal tubular cells: 588.9;Hepatocytes: 1184.0;Proximal enterocytes: 2209.9;Proximal tubular cells: 3547.9" "Cancer enriched" "Detected in many" 5 "liver cancer: 99.3" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 9 "ASC diff: 20.5" "Not detected" "Not detected" "Not detected" "Not detected" "HPA006277, HPA006507, CAB017027" Approved NA NA 840000 "Cluster 81: Kidney & Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "CAB017027: , HPA006277: AB_1079579, HPA006507: AB_1079578" "unprognostic (3.50e-2)" "unprognostic (5.60e-2)" "unprognostic (4.60e-2)" "unprognostic (8.62e-3)" "unprognostic (1.99e-1)" "unprognostic (1.28e-1)" "unprognostic (1.21e-2)" "unprognostic (4.43e-2)" "unprognostic (1.84e-1)" "unprognostic (2.37e-1)" "unprognostic (1.64e-1)" "prognostic favorable (1.47e-5)" "unprognostic (1.03e-1)" "unprognostic (6.40e-2)" "unprognostic (1.05e-3)" "unprognostic (2.21e-1)" 59.2 1.1 0.8 1.7 0.8 0.0 29.8 0.7 1.6 0.0 0.6 57.8 110.4 1.2 0.2 0.4 0.9 5.0 1.0 0.7 1.4 432.1 681.4 0.2 0.3 0.7 0.9 1.6 0.4 0.0 21.1 0.3 0.8 0.2 79.8 0.5 1.1 0.2 0.4 0.9 143.9 2.9 0.6 0.3 0.9 0.0 1.3 0.1 0.8 6.5 0.0 0.8 0.1 0.8 0.0 0.0 0.0 0.0 20.5 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.4 0.3 0.0 0.0 0.1 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 2.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.8 0.7 1.6 0.7 1.4 0.7 0.9 0.8 0.6 1.3 0.8 0.7 0.0 0.0 0.0 21.3 0.1 0.0 0.0 15.9 0.3 0.7 0.6 1.0 61.5 0.6 90.1 0.0 0.1 0.1 703.8 588.9 0.6 0.1 1.3 1.5 2.7 53.9 40.2 0.0 0.0 0.0 2.3 19.9 8.5 8.9 0.1 29.6 1184.0 0.0 3.3 0.0 293.6 0.0 22.6 0.0 0.0 0.0 12.8 0.0 1.9 0.0 9.9 0.0 0.0 0.0 0.1 285.5 0.0 0.0 0.0 2209.9 3547.9 0.0 0.4 0.0 0.3 6.0 0.0 0.1 10.3 0.3 0.3 10.2 1.5 348.5 0.1 PCK2 "PEPCK, PEPCK2" ENSG00000100889 "Phosphoenolpyruvate carboxykinase 2, mitochondrial" Q16822 14 24094053-24110598 "Citric acid cycle related proteins, Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Gluconeogenesis "Decarboxylase, Lyase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 6 "intestine: 196.1;kidney: 99.1;liver: 374.1" "Group enriched" "Detected in many" 4 "Hepatocytes: 309.3;Proximal enterocytes: 752.6;Proximal tubular cells: 237.1" "Cancer enhanced" "Detected in all" "liver cancer: 91.3" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HHSteC: 104.7;hTCEpi: 104.7;SK-MEL-30: 103.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB018734, HPA051162, HPA053502" Enhanced Enhanced Mitochondria NA NA 3500000 "Cluster 51: Monocytes - Innate immune response" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 30: Epithelial cell lines - Translation" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "CAB018734: AB_2160168, HPA051162: AB_2681368, HPA053502: AB_2682171" "unprognostic (3.38e-2)" "unprognostic (1.13e-1)" "unprognostic (1.50e-2)" "unprognostic (4.07e-1)" "unprognostic (3.11e-1)" "unprognostic (2.10e-1)" "prognostic favorable (2.81e-4)" "unprognostic (3.91e-2)" "unprognostic (1.04e-1)" "unprognostic (2.18e-2)" "unprognostic (1.26e-1)" "unprognostic (3.67e-2)" "unprognostic (1.33e-2)" "unprognostic (2.81e-1)" "unprognostic (3.71e-1)" "unprognostic (2.82e-2)" "unprognostic (1.17e-1)" 25.5 10.7 3.2 8.0 3.9 4.5 21.1 3.8 3.3 6.8 3.4 44.8 196.1 5.8 3.1 20.0 5.9 4.5 5.8 3.1 3.9 99.1 374.1 16.5 8.7 4.6 4.2 3.0 34.8 17.4 8.0 2.8 4.1 9.1 19.2 2.7 18.6 7.1 2.6 12.6 136.3 3.8 4.0 21.7 16.0 19.7 3.9 3.7 18.9 1.2 7.5 10.8 10.0 4.3 17.6 9.8 2.7 18.1 11.0 10.5 46.0 21.5 25.6 17.4 28.4 16.1 19.9 44.6 2.6 33.4 5.6 25.4 18.0 28.1 13.8 22.8 0.8 8.0 5.0 84.2 104.7 15.8 33.4 12.9 104.7 10.6 26.5 5.0 14.0 50.6 23.4 79.3 6.4 74.6 4.0 7.6 3.1 39.4 13.0 8.7 10.5 26.0 5.3 26.7 11.3 18.2 16.5 21.2 103.9 2.6 28.5 24.1 2.7 3.8 19.7 5.6 6.0 53.2 18.6 11.0 10.6 24.5 9.6 0.3 11.6 3.5 4.0 21.6 4.1 11.4 4.5 4.5 15.3 7.3 2.7 2.5 1.3 2.2 22.0 2.5 9.1 6.1 3.2 3.9 3.8 3.3 3.1 3.9 4.6 4.2 4.1 4.0 3.9 4.3 4.8 12.8 28.5 1.3 17.9 3.3 10.2 12.3 5.7 4.7 8.6 5.2 1.8 18.6 8.0 18.4 0.0 4.7 4.3 91.2 35.2 18.9 60.1 1.6 5.2 5.6 9.1 24.4 0.5 76.3 14.3 7.4 16.8 4.5 1.3 1.6 13.2 309.3 63.8 0.0 0.9 60.8 18.3 25.8 5.7 30.8 3.4 16.4 7.2 1.0 22.9 5.8 7.2 0.0 0.1 29.0 87.8 3.0 13.3 7.6 752.6 237.1 4.8 5.5 0.0 3.4 18.7 19.8 1.0 9.1 4.8 3.0 7.6 6.8 72.0 15.0 PHYKPL "AGXT2L2, MGC15875" ENSG00000175309 "5-phosphohydroxy-L-lysine phospho-lyase" Q8IUZ5 5 178208471-178232802 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Lyase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036461, HPA063608" Approved Approved Mitochondria Yes No 160000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 34: Non-specific - Transcription" "Cluster 30: Epithelial cell lines - Translation" "Cluster 52: Non-specific - Transcription" Mitochondria "HPA036461: AB_10670717, HPA063608: AB_2685059" "unprognostic (3.29e-3)" "unprognostic (2.60e-1)" "unprognostic (5.51e-2)" "unprognostic (9.75e-2)" "unprognostic (1.28e-1)" "unprognostic (1.47e-1)" "unprognostic (1.24e-1)" "unprognostic (1.06e-2)" "unprognostic (1.68e-2)" "unprognostic (3.29e-1)" "unprognostic (5.38e-2)" "unprognostic (1.02e-3)" "prognostic unfavorable (3.82e-5)" "unprognostic (3.66e-2)" "unprognostic (1.55e-1)" "unprognostic (1.02e-1)" "unprognostic (2.41e-3)" 23.2 10.6 7.4 16.4 8.2 14.9 14.0 6.8 8.6 12.3 8.3 23.9 20.7 14.3 15.8 11.1 13.9 14.4 15.5 6.7 8.3 17.5 42.2 15.8 24.5 11.4 8.3 12.5 15.6 13.7 5.2 16.3 10.0 13.7 30.8 3.4 13.8 12.0 19.6 10.7 24.8 18.5 7.6 17.2 15.5 5.9 9.5 25.1 19.7 18.7 23.6 13.7 9.6 11.7 9.6 3.8 9.0 3.6 21.6 17.4 13.9 5.6 6.2 7.6 11.8 9.7 11.7 13.0 18.4 17.6 9.7 6.2 7.7 14.3 8.5 24.0 8.7 15.6 18.0 7.1 35.1 9.2 11.4 19.6 15.0 9.3 22.4 14.9 24.9 18.6 11.8 26.7 11.3 13.1 13.1 5.5 1.9 11.5 12.4 9.1 4.3 25.0 13.4 8.3 5.7 5.4 9.2 5.2 9.4 10.2 5.5 7.4 9.9 7.8 7.0 5.1 6.2 18.8 5.5 7.2 2.2 9.2 5.2 16.7 41.7 36.9 20.3 46.8 20.4 28.4 22.2 22.9 53.4 26.3 27.3 22.2 9.2 23.7 47.2 70.9 28.6 33.2 7.4 8.2 6.8 8.6 6.7 8.3 11.4 8.3 10.0 7.6 9.5 11.7 23.1 19.2 14.3 31.6 63.0 10.7 43.1 16.1 25.0 21.9 17.2 14.5 17.4 37.1 13.0 23.9 25.0 18.4 72.5 96.1 19.6 24.6 21.7 13.2 27.7 26.2 19.2 30.7 20.7 18.6 20.2 33.4 76.9 13.8 12.7 38.4 31.1 30.1 31.7 15.2 17.9 40.8 6.1 37.1 22.9 55.3 42.6 43.3 24.9 36.5 61.1 25.0 70.0 29.1 45.2 15.1 64.5 25.2 51.4 30.3 119.2 43.1 13.6 26.4 13.1 34.5 23.6 37.2 25.9 14.6 10.4 22.0 58.9 36.3 39.2 36.6 PISD "dJ858B16.2, PSDC" ENSG00000241878 "Phosphatidylserine decarboxylase" Q9UG56 22 31618491-31662432 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Decarboxylase, Lyase" "Cataract, Deafness, Disease variant, Dwarfism, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 223.5;Syncytiotrophoblasts: 245.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MCF7: 80.7" "Low region specificity" "Detected in all" "HPA031090, HPA031091" Approved Approved "Golgi apparatus,Cytosol" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 82: Adipose tissue - ECM organization" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 47: Cytotrophoblasts - Unknown function" "Golgi apparatus, Cytosol" "HPA031090: AB_10600114, HPA031091: AB_10600893" "unprognostic (7.96e-2)" "unprognostic (5.41e-3)" "unprognostic (2.60e-1)" "unprognostic (8.31e-2)" "unprognostic (5.61e-2)" "unprognostic (4.55e-3)" "unprognostic (2.44e-3)" "unprognostic (8.13e-3)" "unprognostic (6.37e-3)" "unprognostic (1.23e-1)" "unprognostic (1.11e-3)" "unprognostic (1.70e-2)" "unprognostic (4.18e-3)" "unprognostic (1.91e-2)" "unprognostic (4.85e-2)" "unprognostic (3.92e-2)" "prognostic favorable (5.27e-5)" 34.1 13.7 6.7 12.2 6.3 18.7 16.0 14.3 9.8 7.4 7.5 8.9 8.8 10.1 4.8 7.3 10.8 7.1 7.3 6.1 7.5 18.9 6.3 14.7 8.4 7.0 6.0 7.6 9.2 5.0 12.6 19.9 6.8 9.0 2.0 3.5 7.5 5.3 5.3 7.8 7.8 3.2 3.8 18.0 8.2 20.3 7.2 3.8 11.5 3.2 4.3 7.3 7.1 5.1 21.7 19.7 5.8 5.8 17.3 6.6 13.2 17.4 13.6 11.9 12.9 28.6 6.6 12.9 18.0 8.8 15.8 24.0 7.9 15.5 1.9 14.4 16.9 13.5 12.8 23.7 35.9 28.7 34.2 12.4 8.5 21.2 9.1 4.9 10.6 9.0 40.3 7.6 6.9 80.7 12.5 12.4 5.7 14.2 8.1 17.4 6.5 13.0 7.6 18.9 14.2 8.4 10.1 31.8 11.0 4.7 26.5 15.5 21.0 14.9 17.7 9.6 16.3 8.9 13.3 16.2 14.2 19.0 12.1 24.1 21.7 16.1 10.6 15.8 10.3 11.9 7.7 9.0 18.3 11.9 10.3 8.6 47.0 10.4 8.7 8.9 8.2 13.8 6.7 6.3 14.3 9.8 6.1 7.5 7.0 6.0 6.8 3.8 7.2 5.1 11.1 16.0 15.6 17.3 12.4 25.6 34.7 31.5 38.7 26.0 18.6 12.6 55.5 12.8 31.1 42.3 20.9 223.5 12.9 12.0 11.7 33.2 60.0 36.2 17.9 19.6 20.9 32.4 40.3 16.8 25.9 13.6 17.3 87.3 18.3 13.2 8.9 7.5 36.4 18.5 35.5 12.9 22.4 36.4 12.7 81.9 9.6 19.8 3.6 9.4 27.1 11.8 24.7 16.1 19.9 15.9 8.4 7.2 11.4 52.1 12.3 13.9 10.9 25.8 19.7 4.9 11.1 25.0 17.9 27.7 21.3 245.0 11.8 8.3 14.2 43.5 PPCDC "FLJ14585, MDS018" ENSG00000138621 "Phosphopantothenoylcysteine decarboxylase" Q96CD2 15 75023586-75117462 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Coenzyme A biosynthesis" "Decarboxylase, Lyase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 5 "dendritic cells: 71.4;granulocytes: 153.5;monocytes: 71.6" "Cell line enhanced" "Detected in all" "Karpas-707: 133.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045667 Approved Approved Cytosol NA NA 25000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 2: Karpas-707 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" Cytosol "HPA045667: AB_2679412" "unprognostic (8.66e-2)" "unprognostic (1.07e-3)" "unprognostic (6.03e-2)" "unprognostic (2.57e-2)" "unprognostic (2.95e-2)" "unprognostic (6.53e-2)" "unprognostic (1.76e-2)" "unprognostic (8.40e-2)" "unprognostic (1.72e-1)" "unprognostic (1.53e-1)" "unprognostic (1.48e-1)" "unprognostic (1.48e-1)" "unprognostic (1.60e-2)" "unprognostic (7.67e-2)" "unprognostic (1.73e-1)" "unprognostic (3.43e-1)" "unprognostic (2.13e-3)" 11.1 19.1 7.4 10.8 8.8 19.7 10.9 8.3 8.4 9.7 8.7 11.5 9.7 8.3 9.8 19.0 10.8 8.4 8.5 6.9 8.0 17.2 13.1 10.8 16.4 9.2 8.8 9.0 16.5 21.3 9.3 9.2 8.5 13.0 9.4 7.6 13.9 7.6 11.9 9.0 9.9 5.4 8.0 18.8 11.3 9.7 8.6 12.1 11.2 5.9 12.3 11.2 10.0 10.3 15.6 28.8 11.8 9.2 7.0 6.4 10.1 15.5 7.0 20.3 15.9 16.9 41.2 17.7 26.8 7.8 12.5 15.9 19.2 25.6 10.4 62.6 23.4 31.1 18.8 18.3 19.9 18.3 38.7 8.6 16.7 21.0 32.3 8.2 16.6 25.8 21.3 133.2 14.8 30.0 10.9 28.1 18.9 32.9 13.4 18.2 23.0 38.3 15.3 22.2 28.3 8.3 22.9 31.3 34.6 13.4 38.7 23.4 9.4 20.6 14.4 10.5 27.6 40.5 29.3 30.1 12.7 45.9 23.7 47.2 23.1 153.5 11.6 65.6 19.4 15.7 10.6 13.0 17.6 8.6 11.7 14.5 139.7 18.5 71.6 71.4 12.7 15.8 7.4 8.8 8.3 8.4 6.9 8.0 9.2 8.8 8.5 8.0 8.6 10.3 10.2 16.0 5.2 2.9 10.5 3.8 6.1 8.5 8.6 2.8 9.6 8.8 4.2 4.3 9.7 9.2 0.0 17.5 16.0 19.7 25.4 17.3 1.0 8.2 4.3 10.7 4.2 11.6 1.4 15.3 13.6 7.4 14.8 8.3 12.0 9.9 10.4 5.3 20.0 8.4 1.7 10.9 12.2 15.7 6.7 2.5 4.4 15.5 14.2 2.8 20.0 4.7 8.2 2.5 4.6 18.0 38.1 5.3 33.9 6.5 10.5 19.0 12.2 10.7 6.6 6.3 8.7 6.9 15.7 10.8 4.0 10.9 9.7 11.3 11.7 13.6 PTGIS "CYP8A1, PGIS" ENSG00000124212 "Prostaglandin I2 synthase" Q16647 20 49503874-49568137 "Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism" "Isomerase, Lyase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "fallopian tube: 80.7;urinary bladder: 81.7" "Cell type enhanced" "Detected in many" "Endothelial cells: 28.1;Fibroblasts: 70.8;Hepatic stellate cells: 117.8;Leydig cells: 26.8;Peritubular cells: 104.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "ASC diff: 45.1;ASC TERT1: 45.2;U-2197: 143.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB009517, HPA014193, HPA052244" Enhanced Approved "Endoplasmic reticulum" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 18: U-2197 - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Endoplasmic reticulum" "CAB009517: AB_2173209, HPA014193: AB_1855746, HPA052244: AB_2732574" "unprognostic (7.68e-2)" "unprognostic (1.90e-1)" "unprognostic (5.09e-3)" "unprognostic (1.38e-2)" "unprognostic (1.80e-2)" "unprognostic (1.74e-1)" "unprognostic (1.21e-2)" "unprognostic (1.29e-2)" "unprognostic (1.25e-1)" "unprognostic (4.02e-2)" "unprognostic (2.45e-2)" "unprognostic (5.22e-2)" "prognostic unfavorable (4.74e-8)" "unprognostic (2.29e-2)" "unprognostic (7.61e-2)" "unprognostic (4.89e-3)" "prognostic unfavorable (9.99e-5)" 43.2 4.7 0.7 9.0 2.5 0.3 24.0 0.3 1.9 29.5 1.8 38.9 3.2 79.0 16.1 16.5 80.7 31.3 40.4 0.5 0.8 4.0 6.0 18.2 0.7 0.6 0.4 38.1 2.5 0.3 0.9 1.1 0.4 22.2 6.6 0.2 7.6 8.3 4.0 7.2 10.5 40.5 0.6 0.5 17.9 5.1 1.0 0.3 7.8 2.4 0.8 81.7 18.2 0.6 0.0 0.1 1.9 0.1 45.1 45.2 0.5 1.0 5.7 0.2 0.0 0.0 0.0 0.1 18.4 13.7 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 5.6 0.0 0.1 3.3 0.0 0.6 0.0 15.1 0.7 0.0 0.0 0.1 0.1 0.0 0.1 0.2 8.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.4 0.4 0.1 0.2 0.0 8.2 0.1 0.0 0.0 0.8 2.4 143.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.1 0.0 0.1 0.0 0.0 0.7 2.5 0.3 1.9 0.5 0.8 0.6 0.4 0.4 0.6 1.0 0.6 5.3 3.2 2.7 0.0 0.0 3.7 0.7 0.0 0.0 1.1 2.2 1.3 5.0 2.8 1.9 3.7 0.0 0.3 0.3 0.0 0.0 0.6 1.8 0.0 0.9 28.1 0.0 2.7 2.7 0.0 0.2 70.8 1.5 0.1 0.0 25.0 117.8 1.0 0.3 0.0 2.4 0.0 0.0 3.1 6.7 3.3 26.8 1.0 1.8 6.5 0.1 0.4 0.0 1.0 0.2 1.2 0.0 104.9 0.3 0.4 0.0 0.2 2.2 4.5 0.0 7.9 3.5 0.7 1.4 0.5 4.8 0.3 1.0 0.5 0.0 0.6 PTS PTPS ENSG00000150787 "6-pyruvoyltetrahydropterin synthase" Q03393 11 112226367-112269955 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Tetrahydrobiopterin biosynthesis" Lyase "Disease variant, Phenylketonuria" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001481 Uncertain Approved Cytosol NA NA "Cluster 44: Non-specific - Transcription" "Cluster 35: Non-specific - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 16: Pancreatic endocrine cells - Mixed function" Cytosol "HPA001481: AB_1079716" "unprognostic (2.08e-2)" "unprognostic (1.91e-1)" "unprognostic (9.66e-3)" "unprognostic (8.38e-3)" "unprognostic (4.58e-1)" "unprognostic (3.28e-3)" "unprognostic (2.38e-2)" "unprognostic (1.81e-2)" "unprognostic (2.05e-2)" "unprognostic (8.74e-2)" "unprognostic (2.59e-1)" "unprognostic (7.07e-2)" "unprognostic (3.81e-2)" "unprognostic (1.20e-2)" "unprognostic (2.97e-1)" "unprognostic (1.52e-3)" "unprognostic (1.65e-1)" 11.7 63.0 17.6 10.2 18.7 22.7 20.5 20.2 27.6 17.5 20.2 18.9 15.0 13.6 29.7 29.0 11.7 20.6 8.8 16.5 25.1 44.7 68.9 7.8 10.5 23.1 26.1 9.9 15.0 29.0 32.8 18.0 24.6 21.1 21.5 19.0 17.5 16.4 18.5 17.0 16.1 13.0 19.7 7.7 27.4 10.3 20.5 4.4 23.2 10.9 12.4 21.7 19.2 21.6 24.5 24.2 33.4 12.9 23.9 26.8 35.4 78.3 38.8 45.5 48.5 57.0 26.1 28.5 53.5 51.6 60.8 38.0 47.5 54.8 50.6 19.7 28.8 7.5 44.6 55.8 70.9 18.4 4.0 47.8 77.1 43.9 53.0 36.5 35.2 24.6 24.9 16.8 30.1 29.8 14.8 23.8 23.1 54.2 48.3 9.4 6.3 37.6 101.2 38.8 32.2 32.5 41.1 43.8 26.0 109.0 32.3 15.2 40.2 42.5 43.0 49.7 60.7 9.9 20.8 69.4 29.3 19.4 44.1 1.1 0.4 0.4 1.2 0.7 1.3 1.5 1.7 1.8 0.7 1.6 1.1 1.5 0.2 1.5 2.0 2.0 1.9 0.7 17.6 18.7 20.2 27.6 16.5 25.1 23.1 26.1 24.6 19.7 20.5 21.6 43.7 19.2 26.5 13.1 28.6 122.6 80.4 146.2 59.2 17.4 69.4 69.0 95.0 47.1 85.7 55.2 0.0 56.7 41.4 80.0 211.3 91.9 5.5 66.4 37.0 42.8 80.0 23.2 16.8 78.9 120.7 47.9 37.8 72.6 20.8 45.1 34.6 123.6 36.9 10.1 25.4 73.1 150.5 21.4 38.1 7.6 14.6 28.4 26.6 15.0 26.1 48.5 22.6 17.6 36.1 114.4 74.4 25.9 33.0 91.9 58.3 151.0 80.8 18.3 26.3 22.7 70.8 23.3 92.6 65.4 131.1 70.3 28.5 59.6 44.4 114.9 RNASE1 "RAC1, RNS1" ENSG00000129538 "Ribonuclease A family member 1, pancreatic" P07998 14 20801228-20802855 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Endonuclease, Hydrolase, Lyase, Nuclease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 9 "pancreas: 9121.6" "Cell type enhanced" "Detected in many" "Adipocytes: 826.6;Alveolar cells type 1: 929.5;Alveolar cells type 2: 818.4;Gastric mucus-secreting cells: 821.1;Hepatic stellate cells: 650.3;Hofbauer cells: 1583.4;Intestinal goblet cells: 663.8;Macrophages: 632.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "classical monocyte: 9.7;myeloid DC: 20.3" "Group enriched" "Detected in many" 9 "dendritic cells: 20.3;monocytes: 9.7" "Cell line enhanced" "Detected in many" "HUVEC TERT2: 286.8;OE19: 67.4;RT4: 114.2;TIME: 179.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA001140 Enhanced Approved Nucleoplasm,Vesicles "Secreted to digestive system" NA NA 1100000000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 4: Macrophages - Innate immune response" Vesicles Nucleoplasm "HPA001140: AB_1079816" "unprognostic (2.32e-2)" "unprognostic (3.16e-2)" "unprognostic (9.51e-3)" "unprognostic (7.77e-2)" "unprognostic (6.93e-2)" "unprognostic (1.28e-1)" "unprognostic (3.42e-3)" "unprognostic (6.59e-3)" "unprognostic (4.69e-2)" "unprognostic (7.92e-2)" "unprognostic (6.32e-2)" "unprognostic (3.56e-2)" "unprognostic (5.14e-3)" "unprognostic (1.11e-2)" "unprognostic (1.47e-1)" "unprognostic (2.43e-2)" "unprognostic (1.67e-1)" 694.2 501.3 336.6 131.3 466.1 6.2 353.3 404.4 556.1 203.9 294.9 378.4 176.7 139.4 112.0 194.0 232.0 406.4 377.7 351.3 380.9 253.0 54.5 775.9 187.8 438.9 408.3 190.6 9121.6 60.6 43.9 897.4 403.7 83.9 425.2 3.1 168.0 149.7 127.6 118.1 201.8 285.6 357.3 353.1 1003.5 977.5 465.4 177.6 119.7 280.6 68.8 374.7 107.9 533.7 0.0 1.4 0.5 0.0 0.0 0.0 4.4 0.0 0.0 0.0 0.0 6.7 0.0 0.3 1.7 0.0 2.2 0.6 0.0 1.4 0.0 0.1 0.1 5.3 0.1 0.8 0.0 0.2 1.1 0.0 0.0 0.0 0.0 0.0 286.8 0.0 31.4 0.4 0.0 0.0 0.3 2.0 1.2 67.4 0.0 0.2 0.1 1.5 0.2 114.2 1.2 1.4 0.0 0.8 0.3 2.0 0.3 0.1 179.3 0.0 2.7 1.8 0.3 0.6 0.1 0.1 4.6 0.1 3.8 1.6 9.7 0.0 0.0 1.2 0.0 0.0 0.0 0.0 20.3 0.1 0.0 0.0 0.1 0.0 0.0 5.0 0.0 2.4 336.6 466.1 404.4 556.1 351.3 380.9 438.9 408.3 403.7 357.3 465.4 533.7 826.6 929.5 818.4 1.6 11.1 35.6 1.0 1.9 15.9 0.1 6.2 11.7 59.8 27.1 174.0 16.5 0.0 12.9 5.7 261.8 0.0 8.8 20.0 3.8 1.9 581.7 48.7 28.0 0.5 315.2 14.6 58.4 821.1 3.4 25.2 103.8 650.3 7.9 1583.4 1.7 0.8 663.8 8.2 267.9 197.5 57.1 32.0 632.8 40.9 36.5 3.4 0.8 0.0 1.0 232.3 286.8 246.7 10.9 7.5 1.4 81.7 0.9 34.9 2.7 98.6 20.7 31.4 16.4 6.6 16.6 28.1 25.9 10.6 392.8 162.9 3.8 RNASE2 "EDN, RAF3, RNS2" ENSG00000169385 "Ribonuclease A family member 2" P10153 14 20955487-20956436 "Enzymes, Plasma proteins, Predicted secreted proteins" Chemotaxis "Endonuclease, Hydrolase, Lyase, Nuclease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 49 "bone marrow: 1713.7" "Cell type enhanced" "Detected in some" "Erythroid cells: 30.7;Kupffer cells: 174.3;Macrophages: 82.2;monocytes: 54.6" "Cancer enriched" "Detected in many" 7 "glioma: 14.1" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "basophil: 457.5;eosinophil: 1352.6" "Lineage enriched" "Detected in many" 7 "granulocytes: 1352.6" "Group enriched" "Detected in some" 303 "HL-60: 539.0;NB-4: 539.8;THP-1: 1405.4;U-937: 1295.9" HPA044983 Enhanced "Secreted to blood" NA NA 200000000 "Cluster 49: Eosinophils - Unknown function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 32: U-937 - Innate immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "HPA044983: AB_10963689" "unprognostic (6.66e-2)" "unprognostic (3.00e-1)" "unprognostic (6.85e-2)" "unprognostic (7.68e-2)" "unprognostic (2.73e-2)" "unprognostic (9.26e-2)" "unprognostic (4.94e-3)" "unprognostic (6.77e-2)" "unprognostic (9.54e-2)" "unprognostic (3.24e-2)" "unprognostic (3.25e-2)" "unprognostic (3.45e-1)" "prognostic unfavorable (3.28e-13)" "unprognostic (2.27e-2)" "unprognostic (7.14e-3)" "unprognostic (5.33e-2)" "unprognostic (1.50e-1)" 7.1 6.0 3.0 9.1 2.8 1713.7 1.7 2.9 5.5 2.3 4.4 2.2 0.2 2.1 0.3 0.9 5.7 2.6 4.0 2.8 4.2 1.7 4.6 12.2 1.9 5.4 4.1 1.5 1.7 0.5 1.7 1.8 4.4 1.7 0.7 1.7 1.9 0.2 0.7 2.9 1.4 9.7 4.5 35.1 2.1 0.7 4.2 14.8 0.9 0.6 0.6 5.2 1.4 6.3 1.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 3.1 0.0 539.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 539.8 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.3 0.0 1.3 0.0 0.0 1405.4 0.0 0.0 0.1 0.0 1.2 0.0 0.2 0.7 0.0 1295.9 0.0 457.5 109.0 1352.6 0.4 19.3 0.8 0.3 0.4 0.0 191.8 0.4 0.4 0.4 9.8 0.1 2.8 2.6 0.1 39.9 3.0 2.8 2.9 5.5 2.8 4.2 5.4 4.1 4.4 4.5 4.2 6.3 0.2 3.2 0.5 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.1 1.4 0.0 1.9 0.0 0.5 0.0 0.0 1.3 0.0 30.7 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 1.4 2.2 13.0 0.0 0.0 0.0 0.0 174.3 0.7 1.7 0.3 82.2 0.0 0.0 54.6 0.1 2.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4 19.7 0.0 0.1 0.1 0.4 0.0 0.0 0.0 0.5 0.0 0.0 0.0 RNASET2 "bA514O12.3, FLJ10907, RNASE6PL" ENSG00000026297 "Ribonuclease T2" O00584 6 166922113-166957191 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Immunity, Innate immunity" "Endonuclease, Hydrolase, Lyase, Nuclease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 490.2;Glandular and luminal cells: 761.3;Hofbauer cells: 382.2;Kupffer cells: 484.7;Macrophages: 418.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "THP-1: 497.9" "HPA029013, HPA066509" Approved "Secreted to blood" NA NA 15000000 "Cluster 52: Eosinophils - Transcription" "Cluster 50: Non-specific - Ribosome" "Cluster 43: THP-1 - Innate immune response" "Cluster 44: Endometrium - Transcription" "HPA029013: AB_10602922, HPA066509: AB_2685682" "unprognostic (4.18e-2)" "unprognostic (2.57e-1)" "unprognostic (1.44e-1)" "unprognostic (1.06e-1)" "unprognostic (4.13e-2)" "unprognostic (9.33e-2)" "unprognostic (1.76e-2)" "unprognostic (1.30e-1)" "unprognostic (1.15e-2)" "unprognostic (8.11e-2)" "unprognostic (1.79e-1)" "unprognostic (5.06e-2)" "prognostic unfavorable (1.70e-14)" "unprognostic (5.03e-2)" "unprognostic (7.34e-2)" "unprognostic (6.29e-2)" "unprognostic (1.01e-2)" 34.9 35.0 50.1 68.6 50.4 124.3 50.2 52.2 65.9 161.5 52.3 74.0 57.6 49.1 140.7 24.8 134.6 69.6 19.8 49.5 53.5 31.2 52.4 47.2 117.4 68.2 54.3 36.2 144.7 40.7 26.3 43.5 66.2 51.9 89.9 8.3 112.8 94.1 7.3 25.4 65.4 27.8 61.9 195.1 72.9 13.3 59.1 43.8 76.7 12.1 86.9 54.9 32.2 79.8 12.8 14.2 12.6 37.8 57.0 40.6 8.4 15.8 21.2 7.3 7.4 33.7 19.9 11.1 149.8 41.3 16.7 41.0 20.8 18.6 4.3 15.9 35.1 10.2 20.6 84.6 19.1 152.7 37.3 23.9 33.6 4.3 2.7 30.4 10.1 21.7 20.9 94.5 10.9 44.9 12.6 109.5 6.4 140.0 13.0 25.0 16.6 131.7 136.3 9.9 4.4 28.7 32.0 100.4 8.3 22.3 13.1 497.9 19.3 14.9 9.8 43.7 13.5 15.0 19.5 1.4 32.3 149.2 10.3 116.9 185.6 674.8 29.1 277.0 53.4 136.7 159.9 72.3 226.4 119.6 128.4 41.4 438.9 30.7 368.8 369.3 90.8 179.8 50.1 50.4 52.2 65.9 49.5 53.5 68.2 54.3 66.2 61.9 59.1 79.8 21.8 19.2 29.3 10.1 270.1 43.3 116.4 45.1 72.3 10.5 97.0 95.1 9.5 47.1 28.0 38.6 0.0 63.4 286.8 133.7 23.5 59.2 10.3 490.2 78.9 44.9 75.4 27.6 13.6 27.4 58.8 45.8 80.0 761.3 71.7 38.6 19.2 20.0 382.2 13.5 37.1 204.0 24.4 484.7 187.7 11.3 35.4 418.2 58.7 113.4 146.1 24.4 64.9 14.6 1.7 74.1 324.8 29.3 158.6 61.2 178.5 19.6 19.0 7.1 26.3 31.9 18.6 10.0 23.1 58.3 34.5 27.8 149.2 15.3 193.0 103.9 RPS3 "FLJ26283, FLJ27450, MGC87870, S3" ENSG00000149273 "Ribosomal protein S3" P23396 11 75399515-75422280 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins" "Apoptosis, Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Transcription, Transcription regulation, Translation regulation" "DNA-binding, Lyase, Ribonucleoprotein, Ribosomal protein, RNA-binding" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" HPA063339 Uncertain Supported "Endoplasmic reticulum,Cytosol" NA NA 560000 "Cluster 30: Non-specific - Translation" "Cluster 50: Non-specific - Ribosome" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 32: Non-specific - Translation" "Endoplasmic reticulum, Cytosol" "HPA063339: AB_2684990" "unprognostic (3.62e-2)" "unprognostic (6.94e-3)" "unprognostic (2.64e-1)" "unprognostic (1.44e-2)" "unprognostic (5.55e-2)" "unprognostic (1.08e-2)" "unprognostic (1.22e-2)" "unprognostic (1.35e-1)" "unprognostic (2.69e-1)" "unprognostic (5.75e-2)" "unprognostic (3.27e-3)" "unprognostic (1.96e-1)" "prognostic unfavorable (6.92e-6)" "unprognostic (3.22e-1)" "unprognostic (2.94e-1)" "unprognostic (1.89e-2)" "unprognostic (2.19e-1)" 1139.4 747.7 431.1 955.9 446.8 2080.0 1950.0 427.3 575.6 1529.6 427.4 1220.4 946.0 1060.9 708.7 1669.8 1270.5 556.5 734.1 417.1 441.6 672.3 631.7 846.0 1663.4 446.6 430.8 2914.0 1761.9 356.4 660.5 760.6 442.8 929.1 919.3 352.7 1049.9 662.1 1125.5 1783.9 1128.2 739.8 444.4 1346.4 1082.2 287.7 435.1 1403.5 717.1 749.0 1360.4 1054.9 1384.5 446.9 1899.8 1145.7 1595.6 1767.5 1970.0 3482.1 2060.8 1763.7 2256.3 2289.4 1481.2 3331.6 2196.8 6547.1 2108.6 1598.8 1261.5 2672.3 2085.6 3290.7 2093.8 1749.1 1618.9 2688.6 1042.6 1490.2 2931.1 4398.6 1690.0 4124.1 4397.7 1568.8 4323.1 2684.0 3055.0 2876.5 2736.9 1809.7 2089.7 2071.2 2660.9 2112.4 2007.4 6591.3 1342.5 2482.3 5580.2 4834.0 2275.9 1551.8 1366.7 1933.6 1299.3 3050.2 1897.1 1535.9 3123.3 3289.9 2470.7 1099.6 1822.9 1515.3 1627.3 1647.2 2198.0 7283.3 660.4 2409.4 1138.1 430.3 770.8 245.5 1405.7 515.5 1924.9 1602.2 1823.1 1489.0 1099.3 1454.0 2102.1 1633.9 174.3 1142.6 512.4 960.4 1283.7 4244.2 431.1 446.8 427.3 575.6 417.1 441.6 446.6 430.8 442.8 444.4 435.1 446.9 1993.9 932.7 1604.3 18.6 4790.5 6297.7 7369.7 5554.5 4497.7 423.9 6945.0 9521.7 418.9 2088.9 2555.7 726.4 133.5 6188.6 4009.1 1694.4 2183.4 2376.0 430.9 939.2 3054.9 2780.8 2067.1 3428.9 28.3 5373.2 9079.0 2364.6 1651.9 1363.9 1641.6 4246.7 2916.7 1369.0 3662.5 132.9 32.6 4425.4 1621.5 3089.2 4666.7 968.5 3755.0 2393.1 2835.3 38.4 3626.4 957.1 4120.5 19.6 47.5 3805.0 3535.7 1803.2 2848.0 5827.8 2969.4 2226.4 797.6 505.5 1117.5 3204.8 3221.9 449.3 618.6 5734.6 7842.8 5867.5 4904.4 4865.2 5657.1 7206.9 SCLY SCL ENSG00000132330 "Selenocysteine lyase" Q96I15 2 238060924-238099413 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lyase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 39.1" "Group enriched" "Detected in many" 13 "Early spermatids: 90.6;Late spermatids: 156.3" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020190, HPA055760" Uncertain Enhanced "Golgi apparatus" NA NA 300000 "Cluster 26: Non-specific - Mitochondria" "Cluster 29: Non-specific - Vesicular transport" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 31: Spermatids - Spermatogenesis" "Golgi apparatus" "HPA020190: , HPA055760: AB_2682910" "unprognostic (7.39e-3)" "unprognostic (1.43e-1)" "unprognostic (3.29e-2)" "unprognostic (8.65e-5)" "unprognostic (8.96e-2)" "unprognostic (9.85e-3)" "unprognostic (1.14e-3)" "unprognostic (4.24e-2)" "unprognostic (1.59e-2)" "unprognostic (8.38e-2)" "unprognostic (3.98e-3)" "unprognostic (1.03e-2)" "unprognostic (1.02e-3)" "unprognostic (3.73e-1)" "unprognostic (4.37e-2)" "unprognostic (2.50e-3)" "unprognostic (1.98e-1)" 5.1 4.3 7.2 5.3 9.4 5.0 4.9 9.4 9.3 6.8 6.4 7.3 8.5 8.1 5.6 5.9 6.3 3.8 8.1 6.8 8.2 12.9 39.1 4.7 5.7 9.2 8.8 6.3 22.8 6.1 5.0 2.0 9.4 5.9 3.2 4.6 4.4 4.1 6.4 3.5 8.6 3.9 7.3 7.2 5.8 16.8 8.3 5.9 7.2 3.5 4.3 7.8 5.1 10.4 11.1 19.1 11.9 31.1 9.0 6.4 23.2 11.2 5.6 11.3 14.3 11.6 8.0 18.9 3.3 5.9 35.4 16.4 44.1 21.5 10.9 21.2 41.8 21.1 24.0 37.6 16.7 17.6 18.2 7.1 11.6 21.3 22.0 5.1 21.0 26.1 38.0 5.1 11.7 16.9 17.9 33.0 36.4 16.0 15.6 22.0 23.3 18.2 11.3 3.6 13.1 28.9 12.0 19.4 20.6 8.2 6.3 26.5 8.5 16.3 11.8 24.2 23.7 14.2 13.3 9.3 11.3 37.0 14.4 1.1 3.2 4.0 2.6 2.3 2.0 2.6 3.1 4.4 3.3 1.6 2.3 2.6 0.5 2.9 3.5 0.6 3.2 2.8 7.2 9.4 9.4 9.3 6.8 8.2 9.2 8.8 9.4 7.3 8.3 10.4 2.2 0.0 0.0 0.0 4.6 1.7 2.4 1.9 5.7 5.4 1.7 1.9 2.6 1.5 1.2 0.0 8.4 1.4 3.4 1.9 3.9 5.3 90.6 1.7 3.4 2.4 2.4 9.4 0.0 3.7 2.1 1.9 5.1 2.6 0.0 3.5 1.8 3.3 4.0 6.7 0.0 3.3 8.2 0.9 3.2 156.3 3.1 2.1 1.8 0.0 2.7 2.6 2.1 0.0 0.0 3.0 5.0 0.0 4.9 1.9 3.9 2.7 1.9 6.9 0.0 1.9 3.2 6.2 5.6 3.4 1.6 0.7 4.4 2.2 4.8 1.8 SDS SDH ENSG00000135094 "Serine dehydratase" P20132 12 113392445-113426301 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Gluconeogenesis Lyase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 34 "liver: 1024.6" "Cell type enhanced" "Detected in some" "Hepatocytes: 364.6;Hofbauer cells: 199.4;Langerhans cells: 111.9;Macrophages: 93.7;monocytes: 97.6" "Cancer enriched" "Detected in all" 31 "liver cancer: 165.3" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 10 "myeloid DC: 11.6" "Lineage enriched" "Detected in single" 15 "dendritic cells: 11.6" "Cell line enhanced" "Detected in some" "HMC-1: 1.7;SK-BR-3: 1.0" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA039230 Uncertain Approved Mitochondria,Cytosol NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 3: HMC-1 - Innate immune response" "Cluster 15: Hepatocytes - Hemostasis" Cytosol Mitochondria "HPA039230: AB_10674281" "unprognostic (1.31e-1)" "prognostic favorable (5.24e-4)" "unprognostic (6.37e-3)" "unprognostic (6.94e-2)" "unprognostic (9.19e-3)" "unprognostic (2.65e-2)" "unprognostic (2.35e-2)" "unprognostic (8.85e-2)" "unprognostic (1.79e-1)" "unprognostic (2.55e-1)" "unprognostic (4.89e-2)" "unprognostic (3.20e-1)" "unprognostic (4.08e-3)" "unprognostic (2.12e-1)" "unprognostic (2.07e-2)" "unprognostic (4.35e-1)" "unprognostic (2.99e-2)" 3.2 10.0 13.5 4.3 18.8 1.5 1.9 13.2 13.0 1.1 8.7 3.3 1.9 0.9 0.3 0.3 0.6 4.1 1.2 13.4 15.2 0.5 1024.6 6.3 0.8 30.0 27.7 0.5 1.0 0.8 1.1 2.9 16.1 1.1 2.3 3.0 2.7 0.1 0.8 0.2 2.0 0.5 10.5 1.7 2.9 0.4 19.1 0.4 1.0 0.0 0.3 3.8 0.3 11.4 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.1 0.7 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.4 0.2 0.0 0.0 0.2 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.4 0.0 0.1 0.2 0.0 0.4 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.5 1.0 0.2 0.0 0.3 0.5 0.2 0.0 0.2 0.3 0.0 0.2 0.1 0.0 0.3 0.2 0.1 0.2 0.7 0.0 0.0 0.6 0.0 0.0 0.0 0.0 11.6 0.0 0.0 0.0 0.5 0.1 0.1 1.1 0.0 0.4 13.5 18.8 13.2 13.0 13.4 15.2 30.0 27.7 16.1 10.5 19.1 11.4 0.2 0.0 0.6 15.0 5.1 2.4 0.4 0.0 0.0 0.2 0.4 1.5 0.5 17.2 0.0 0.0 0.0 0.8 0.3 0.1 0.0 2.8 0.0 0.1 0.2 1.3 0.0 29.5 0.1 0.4 1.3 0.6 0.0 0.1 0.0 0.1 18.9 364.6 199.4 0.0 0.1 0.0 0.0 45.1 111.9 0.0 0.0 93.7 1.8 0.0 97.6 1.9 0.0 1.0 0.1 0.2 0.0 0.0 0.0 0.3 0.0 0.5 0.0 0.5 0.0 0.3 0.6 0.0 0.0 0.4 3.1 2.5 2.4 0.8 0.0 0.1 SDSL "cSDH, SDS-RS1" ENSG00000139410 "Serine dehydratase like" Q96GA7 12 113422380-113438276 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 104.6" "Cell type enhanced" "Detected in many" "Distal tubular cells: 78.2;Hepatocytes: 116.7;Hofbauer cells: 95.7;monocytes: 103.1;Proximal tubular cells: 115.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 6 "classical monocyte: 8.7;intermediate monocyte: 10.0;myeloid DC: 18.5;plasmacytoid DC: 17.8" "Group enriched" "Detected in many" 6 "dendritic cells: 18.5;monocytes: 10.0" "Cell line enhanced" "Detected in many" "HMC-1: 51.4;MCF7: 90.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA005740 Approved Approved Cytosol NA NA 48000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 15: Liver - Metabolism" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 3: Monocytes - Immune response regulation" Cytosol "HPA005740: AB_10601486" "unprognostic (1.34e-1)" "unprognostic (8.33e-2)" "unprognostic (3.62e-2)" "unprognostic (3.54e-2)" "unprognostic (2.24e-2)" "unprognostic (6.17e-3)" "unprognostic (1.57e-1)" "unprognostic (6.46e-2)" "unprognostic (8.22e-2)" "unprognostic (2.00e-2)" "prognostic favorable (8.58e-4)" "unprognostic (2.93e-1)" "prognostic favorable (3.09e-5)" "unprognostic (2.22e-2)" "unprognostic (1.43e-1)" "unprognostic (2.54e-1)" "unprognostic (7.33e-2)" 4.5 33.1 12.7 7.1 14.2 3.2 4.9 16.4 15.2 4.6 10.8 12.2 16.8 4.8 9.9 2.5 7.9 7.7 12.8 11.8 16.1 34.9 104.6 5.7 3.4 18.7 16.2 4.6 18.7 12.4 15.5 4.4 16.0 8.5 8.5 2.4 4.8 6.6 3.0 1.3 12.2 5.2 15.8 5.8 9.1 10.6 16.4 1.5 23.9 1.3 1.7 6.2 1.4 17.4 8.5 33.3 4.7 14.1 0.9 1.9 3.2 4.8 1.2 5.2 4.4 14.1 8.7 0.4 24.2 8.1 14.4 8.6 2.2 11.4 1.7 20.5 8.4 22.1 8.5 6.3 27.5 2.8 51.4 4.4 16.0 12.8 18.8 5.9 8.0 0.0 17.3 6.6 6.5 90.2 0.1 10.2 4.6 9.6 14.6 0.0 7.0 16.5 13.6 10.6 1.5 0.5 20.6 23.6 18.4 4.2 28.6 24.8 7.2 6.2 11.9 26.9 4.2 1.4 1.4 0.3 26.3 8.4 7.8 0.2 8.7 0.0 0.0 10.0 0.0 2.2 0.0 0.0 18.5 0.1 0.0 0.0 0.4 1.8 1.3 17.8 0.3 2.5 12.7 14.2 16.4 15.2 11.8 16.1 18.7 16.2 16.0 15.8 16.4 17.4 1.2 0.0 5.1 2.0 3.1 0.9 2.2 7.0 0.0 0.5 15.3 10.2 18.2 27.1 6.3 29.5 2.1 16.3 4.9 43.7 78.2 36.1 0.5 14.8 7.7 4.0 31.8 10.1 1.3 20.1 3.0 4.5 12.8 10.1 43.8 15.3 6.4 116.7 95.7 3.3 0.6 36.4 4.1 18.1 8.4 1.5 2.8 36.9 3.6 1.9 103.1 33.5 0.0 1.5 2.0 16.2 63.2 5.7 0.0 6.1 63.2 115.7 3.8 2.6 0.0 0.2 7.3 0.2 0.4 1.1 0.6 7.3 1.9 29.5 31.0 5.9 SGPL1 SPL ENSG00000166224 "Sphingosine-1-phosphate lyase 1" O95470 10 70815948-70881184 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Lipid metabolism, Sphingolipid metabolism" Lyase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RT4: 112.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021125, HPA023086" Enhanced Supported "Endoplasmic reticulum" NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 37: Intestine - Unknown function" "Cluster 15: RT4 - Unknown function" "Cluster 44: Endometrium - Transcription" "Endoplasmic reticulum" "HPA021125: AB_1856803, HPA023086: AB_1856804" "unprognostic (1.14e-1)" "unprognostic (1.77e-1)" "unprognostic (1.15e-1)" "unprognostic (3.07e-2)" "unprognostic (2.13e-1)" "unprognostic (2.34e-1)" "unprognostic (7.60e-2)" "unprognostic (2.98e-2)" "unprognostic (2.88e-1)" "unprognostic (1.06e-1)" "unprognostic (1.70e-2)" "unprognostic (2.12e-1)" "unprognostic (9.52e-2)" "unprognostic (3.42e-1)" "unprognostic (2.14e-1)" "unprognostic (9.21e-2)" "unprognostic (4.68e-3)" 12.0 12.7 15.8 18.0 17.4 6.8 13.0 15.2 16.3 17.6 11.0 16.7 16.0 14.4 18.8 27.9 15.3 12.6 6.4 14.7 16.4 15.5 22.9 10.7 18.1 18.6 16.7 9.0 18.5 21.0 9.4 10.0 17.4 17.5 17.9 10.8 14.3 12.4 9.6 30.4 22.8 13.9 17.4 16.1 12.3 14.0 17.7 17.9 20.1 6.0 20.1 25.0 14.7 19.8 26.9 35.2 33.2 38.1 8.9 11.5 22.1 15.5 16.4 16.5 21.4 38.4 57.8 24.2 18.0 15.8 15.9 44.1 28.8 31.0 23.5 39.1 15.6 2.5 17.5 46.2 33.6 10.6 20.9 21.8 51.4 22.1 57.6 34.6 10.4 22.3 7.2 20.4 23.6 29.6 13.2 7.1 15.0 35.4 19.5 16.6 25.2 9.1 26.3 112.1 22.6 27.5 30.9 46.6 28.5 25.9 24.3 7.5 20.3 14.8 38.7 11.6 30.1 8.4 12.6 11.0 14.7 19.3 10.7 1.1 18.2 14.0 18.0 34.6 16.5 7.2 11.5 14.7 16.2 8.7 8.5 13.5 15.0 18.8 44.9 8.9 11.8 12.4 15.8 17.4 15.2 16.3 14.7 16.4 18.6 16.7 17.4 17.4 17.7 19.8 3.8 16.0 6.4 32.3 11.0 12.2 17.8 21.4 8.0 6.3 15.8 9.8 6.3 27.1 23.2 46.0 20.9 7.3 16.0 41.5 3.9 36.2 2.9 30.2 13.3 7.3 25.1 4.4 48.7 37.6 13.8 10.1 6.6 46.1 14.7 23.1 7.1 44.5 27.6 15.2 38.8 21.2 22.4 43.1 16.1 5.2 11.5 25.7 7.2 35.6 22.7 9.8 25.7 41.7 43.8 55.6 18.8 20.3 5.9 26.0 53.5 12.0 26.6 9.7 6.6 13.3 19.0 20.0 34.0 15.9 22.7 6.3 11.1 18.2 20.9 25.3 SRR "ILV1, ISO1" ENSG00000167720 "Serine racemase" Q9GZT4 17 2303383-2325260 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Allosteric enzyme, Isomerase, Lyase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Spermatocytes: 23.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007529, CAB015343" Approved Approved Vesicles NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Vesicles "CAB015343: AB_2195009, HPA007529: AB_2667853" "unprognostic (2.96e-1)" "unprognostic (7.86e-2)" "unprognostic (6.01e-2)" "prognostic favorable (6.20e-5)" "unprognostic (3.05e-1)" "unprognostic (1.57e-2)" "unprognostic (4.32e-2)" "unprognostic (9.97e-2)" "unprognostic (9.09e-2)" "unprognostic (4.85e-2)" "prognostic favorable (8.16e-4)" "unprognostic (5.17e-2)" "prognostic favorable (2.45e-6)" "unprognostic (6.14e-2)" "unprognostic (1.99e-1)" "unprognostic (1.89e-1)" "unprognostic (5.84e-2)" 10.5 7.8 11.0 6.6 11.5 13.9 8.9 12.5 13.1 6.8 13.0 9.4 6.9 7.5 10.3 10.9 8.7 8.3 10.9 9.4 13.4 9.0 8.2 6.1 6.6 11.2 12.4 8.4 11.9 12.3 4.9 5.4 12.7 8.4 7.5 16.6 10.7 7.7 15.6 11.8 5.9 7.0 11.1 6.9 8.0 7.1 12.5 9.0 11.8 6.7 5.4 8.4 5.3 11.8 14.8 27.0 42.7 17.9 24.9 24.4 22.8 29.8 20.2 19.4 20.5 25.3 18.1 27.5 4.1 29.1 14.3 30.2 12.2 11.4 24.6 32.6 26.0 14.6 20.3 9.6 22.5 4.3 8.0 22.9 11.5 41.4 21.0 21.2 28.6 28.2 15.2 19.8 43.9 8.4 28.7 5.8 10.0 13.8 19.9 45.5 48.8 13.3 22.9 6.9 9.2 23.4 26.8 3.3 14.3 14.6 20.7 10.3 21.3 21.4 14.7 24.7 19.0 16.7 26.0 5.1 36.9 13.7 29.8 4.3 8.1 5.6 8.8 8.4 9.1 10.1 11.2 9.1 15.6 10.2 9.2 12.1 1.0 15.7 14.0 11.0 8.8 8.5 11.0 11.5 12.5 13.1 9.4 13.4 11.2 12.4 12.7 11.1 12.5 11.8 5.0 3.2 3.7 3.6 2.1 2.9 3.5 17.4 1.8 8.5 5.5 4.6 4.2 1.5 8.4 1.8 0.0 5.9 3.4 3.0 13.7 9.6 1.9 6.6 5.5 5.4 1.8 5.2 3.5 6.6 3.2 5.7 3.6 4.6 0.0 13.2 8.2 3.2 9.3 16.8 4.9 2.5 12.2 4.6 4.9 1.5 4.1 3.7 5.4 4.7 9.3 11.0 5.2 5.0 7.8 6.7 0.8 5.3 6.1 2.9 2.9 6.3 10.2 5.6 0.0 4.6 6.5 23.3 13.1 4.7 2.4 3.4 2.3 9.7 3.5 4.0 TBXAS1 "CYP5, CYP5A1, THAS, TS, TXAS, TXS" ENSG00000059377 "Thromboxane A synthase 1" P24557 7 139777051-140020325 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism" "Isomerase, Lyase, Monooxygenase, Oxidoreductase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 57.8" "Group enriched" "Detected in many" 4 "granulocytes: 71.0;Hofbauer cells: 88.8;Kupffer cells: 193.6;Macrophages: 132.9;Microglial cells: 191.1;monocytes: 63.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 14 "basophil: 324.3;classical monocyte: 322.4;eosinophil: 333.6;intermediate monocyte: 466.0;myeloid DC: 129.0;neutrophil: 271.1;non-classical monocyte: 423.1" "Group enriched" "Detected in all" 22 "dendritic cells: 129.0;granulocytes: 333.6;monocytes: 466.0" "Cell line enhanced" "Detected in many" "NB-4: 76.7;PC-3: 23.7;RPTEC TERT1: 21.0;U-937: 60.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in single" "HPA031257, HPA031258, HPA031259" Enhanced Approved "Endoplasmic reticulum,Cytosol" NA NA 890000 "Cluster 7: Monocytes - Unknown function" "Cluster 64: Macrophages - Immune response" "Cluster 24: NB-4 - Immune response" "Cluster 4: Macrophages - Innate immune response" "Endoplasmic reticulum, Cytosol" "HPA031257: AB_2673812, HPA031258: AB_2673813, HPA031259: AB_2673814" "unprognostic (4.46e-2)" "unprognostic (3.07e-1)" "unprognostic (8.80e-2)" "unprognostic (1.12e-1)" "unprognostic (2.72e-1)" "unprognostic (9.41e-2)" "unprognostic (5.10e-2)" "unprognostic (3.12e-1)" "unprognostic (2.38e-1)" "unprognostic (3.07e-2)" "unprognostic (1.11e-1)" "unprognostic (3.03e-2)" "prognostic unfavorable (1.14e-4)" "unprognostic (1.52e-1)" "unprognostic (5.00e-3)" "unprognostic (8.53e-2)" "unprognostic (5.34e-2)" 13.2 10.8 5.3 28.1 5.1 24.8 8.2 5.4 5.9 5.4 5.8 10.1 10.3 3.2 2.0 5.4 4.9 21.2 3.3 4.5 6.8 5.8 12.8 23.9 12.4 10.0 6.6 2.9 3.6 2.9 2.3 14.2 8.8 6.4 13.0 1.6 9.0 4.0 1.0 1.3 11.9 12.6 8.9 57.8 11.2 1.4 9.7 15.1 1.8 3.3 8.3 13.9 2.1 14.7 0.2 5.4 0.3 0.1 1.2 3.9 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.0 12.1 0.0 0.3 0.0 0.0 0.0 0.0 9.4 0.7 17.8 0.0 0.0 1.6 6.2 15.3 2.1 0.0 0.0 0.9 1.1 2.3 0.1 0.6 2.2 0.6 0.2 2.4 76.7 0.2 18.0 23.7 2.6 0.0 1.2 21.0 0.0 0.2 1.1 0.2 0.0 0.8 0.0 0.0 14.4 2.0 0.6 0.2 1.4 1.0 4.6 0.9 0.3 0.4 60.8 1.7 324.3 322.4 333.6 7.3 466.0 11.9 8.3 13.5 3.7 129.0 4.5 2.3 1.3 271.1 11.9 423.1 22.6 13.9 216.7 5.3 5.1 5.4 5.9 4.5 6.8 10.0 6.6 8.8 8.9 9.7 14.7 3.9 3.2 10.8 8.1 9.9 0.4 1.2 0.5 2.8 1.0 3.0 3.0 1.1 5.7 1.7 1.8 6.2 0.6 16.4 0.8 9.8 5.2 0.4 1.0 0.6 5.0 1.8 12.8 1.2 9.5 0.5 2.9 7.1 3.8 71.0 0.5 16.8 8.6 88.8 3.3 1.8 1.9 12.2 193.6 19.5 0.7 0.3 132.9 3.6 191.1 63.7 4.9 26.8 3.0 5.9 4.4 7.9 0.0 16.4 5.8 0.2 6.3 1.0 4.1 19.7 1.3 1.7 0.5 0.7 26.2 0.6 0.5 13.4 0.3 2.7 1.2 TGDS "SDR2E1, TDPGD" ENSG00000088451 "TDP-glucose 4,6-dehydratase" O95455 13 94574054-94596242 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Lyase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HL-60: 75.2;U-698: 97.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039927, HPA040857" Approved Approved Nucleoplasm,Nucleoli,Cytosol NA No "Cluster 44: Non-specific - Transcription" "Cluster 29: Non-specific - Vesicular transport" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 33: Fibroblasts - ECM organization" Nucleoplasm "Nucleoli, Cytosol" "HPA039927: AB_10795238, HPA040857: AB_10794867" "unprognostic (4.07e-2)" "unprognostic (3.56e-1)" "unprognostic (2.66e-2)" "unprognostic (2.76e-1)" "unprognostic (1.27e-1)" "unprognostic (2.25e-2)" "unprognostic (1.60e-1)" "unprognostic (2.87e-1)" "unprognostic (9.99e-2)" "unprognostic (1.96e-1)" "unprognostic (9.17e-2)" "prognostic unfavorable (2.48e-4)" "unprognostic (5.51e-2)" "unprognostic (1.13e-2)" "unprognostic (2.26e-1)" "unprognostic (1.71e-2)" "unprognostic (1.09e-1)" 10.4 9.4 5.3 8.2 5.5 6.0 12.4 5.6 8.2 10.4 6.3 8.0 10.2 8.0 11.8 6.9 9.2 6.8 5.4 4.9 5.6 10.9 30.0 7.1 12.9 5.6 5.4 12.1 10.0 8.1 8.4 10.1 5.9 7.9 9.5 6.9 7.7 7.6 4.1 7.5 9.2 6.7 5.6 9.2 9.1 6.0 5.3 14.1 13.3 4.3 11.0 9.1 6.4 6.6 16.7 7.2 11.6 10.6 17.2 13.5 14.1 15.3 14.9 14.2 13.4 18.9 15.9 26.0 14.8 10.9 8.8 10.4 20.1 11.9 14.9 20.3 7.7 20.7 8.1 18.1 21.0 75.2 13.8 14.9 9.5 8.0 22.8 11.1 13.2 18.9 21.3 8.9 13.3 10.8 20.6 38.4 15.2 26.8 8.3 17.1 11.4 15.9 18.3 7.4 15.9 8.9 11.6 24.2 43.5 19.1 10.2 39.8 12.2 5.6 14.5 8.6 12.6 20.0 11.4 97.5 14.9 26.5 15.5 14.7 5.5 10.8 9.6 6.6 14.9 9.5 11.6 10.7 8.7 7.1 16.8 12.5 1.6 12.1 8.3 7.6 13.8 6.9 5.3 5.5 5.6 8.2 4.9 5.6 5.6 5.4 5.9 5.6 5.3 6.6 7.4 12.8 6.8 8.1 12.8 2.4 9.2 15.9 6.8 4.3 7.8 7.9 5.2 8.6 11.9 7.3 2.1 15.7 12.5 5.8 9.8 11.9 1.2 10.4 8.9 7.0 5.4 3.4 7.7 9.1 17.7 12.9 6.1 6.0 11.4 7.7 7.9 21.4 11.2 1.7 6.7 7.7 8.2 8.8 7.2 1.0 14.3 7.5 8.8 8.4 11.1 7.0 7.2 12.1 10.4 8.9 6.6 8.2 10.7 10.9 10.0 17.6 15.9 4.7 26.3 6.7 8.1 11.9 12.3 8.5 3.7 10.4 11.0 9.2 9.1 9.7 TKFC "DAK, DKFZP586B1621, NET45" ENSG00000149476 "Triokinase and FMN cyclase" Q3LXA3 11 61333220-61353295 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Lyase, Multifunctional enzyme, Transferase" Cataract "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 192.8;liver: 115.8" "Cell type enhanced" "Detected in many" "Hepatocytes: 115.9;Proximal enterocytes: 415.8;Proximal tubular cells: 91.2;Theca cells: 93.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Hep G2: 133.2;RPMI-8226: 140.7;T-47d: 135.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039486, HPA048186" Enhanced Approved Nucleoplasm,Cytosol NA NA 6800000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 25: RPMI-8226 - Immune response" "Cluster 45: Enterocytes - Digestion" Cytosol Nucleoplasm "HPA039486: AB_10795402, HPA048186: AB_2680305" "unprognostic (4.00e-1)" "unprognostic (3.13e-1)" "unprognostic (7.42e-2)" "prognostic favorable (1.32e-5)" "unprognostic (1.07e-1)" "unprognostic (1.19e-1)" "unprognostic (3.02e-2)" "unprognostic (2.81e-3)" "unprognostic (1.49e-1)" "unprognostic (2.47e-1)" "unprognostic (1.51e-1)" "unprognostic (2.15e-1)" "prognostic favorable (8.38e-5)" "unprognostic (2.07e-2)" "unprognostic (8.96e-2)" "unprognostic (3.30e-1)" "unprognostic (4.02e-1)" 9.5 82.8 5.9 9.4 6.0 16.6 12.1 5.8 6.6 9.5 5.7 12.5 192.8 11.0 7.6 16.3 15.4 9.2 7.6 6.4 5.1 45.5 115.8 9.0 13.6 6.8 6.3 10.3 24.0 6.7 14.0 6.1 6.2 12.2 5.7 5.6 16.2 8.9 10.9 17.8 138.0 5.2 6.5 13.0 16.6 28.2 6.0 7.5 14.7 5.6 8.0 10.9 11.0 7.2 19.9 51.3 8.5 30.0 10.7 11.4 24.2 11.7 12.4 10.4 6.9 23.1 47.1 25.0 39.3 8.5 11.0 27.7 16.3 21.8 3.5 42.5 21.7 15.7 26.2 133.2 17.9 13.4 25.0 18.2 14.5 9.9 35.4 9.4 10.7 17.1 27.2 46.7 7.9 91.8 11.9 11.9 23.8 19.2 33.8 20.0 13.8 140.7 17.1 35.0 33.0 29.6 21.0 36.4 19.3 6.0 135.4 9.2 13.0 21.0 21.6 16.6 7.0 85.8 76.5 22.9 21.3 12.3 19.7 2.6 13.4 6.5 7.1 7.8 9.6 10.3 8.3 7.1 21.2 9.7 5.8 6.2 1.2 6.5 6.5 10.1 12.9 9.7 5.9 6.0 5.8 6.6 6.4 5.1 6.8 6.3 6.2 6.5 6.0 7.2 8.0 0.0 14.5 0.0 9.5 0.0 13.8 0.0 11.4 12.8 19.1 16.0 3.8 11.5 6.8 14.7 14.6 31.2 8.3 4.8 29.4 19.6 16.2 16.4 6.6 8.0 13.3 7.8 0.0 14.6 6.2 11.2 20.4 12.1 7.6 10.8 7.5 115.9 17.1 8.4 0.0 31.6 0.0 17.2 0.0 12.0 15.2 8.2 0.0 0.0 21.2 10.0 9.2 0.0 0.0 11.2 32.9 22.6 11.0 11.1 415.8 91.2 10.9 17.8 6.6 4.7 3.6 37.5 14.1 12.6 0.0 15.2 6.5 93.6 47.6 13.4 TPI1 ENSG00000111669 "Triosephosphate isomerase 1" P60174 12 6867119-6870948 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Gluconeogenesis, Glycolysis" "Isomerase, Lyase" "Cancer-related genes, Disease variant, Hereditary hemolytic anemia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 2470.8;tongue: 2005.8" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA050924, HPA053568" Uncertain Approved Nucleoplasm,Vesicles NA NA 170000000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 54: Non-specific - Microtubule organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 16: Pancreatic endocrine cells - Mixed function" Nucleoplasm Vesicles "HPA050924: AB_2681276, HPA053568: AB_2682193" "unprognostic (2.85e-1)" "unprognostic (5.58e-3)" "unprognostic (1.65e-1)" "unprognostic (1.62e-2)" "unprognostic (6.94e-2)" "unprognostic (2.31e-2)" "prognostic unfavorable (1.04e-5)" "unprognostic (4.14e-3)" "unprognostic (7.49e-2)" "unprognostic (2.13e-2)" "unprognostic (2.11e-2)" "unprognostic (1.63e-1)" "prognostic unfavorable (6.54e-4)" "unprognostic (7.04e-2)" "unprognostic (1.82e-1)" "unprognostic (1.53e-1)" "unprognostic (1.11e-2)" 340.4 588.6 446.2 269.7 480.2 334.8 274.5 476.5 541.9 314.1 446.9 425.6 421.0 240.5 220.2 764.4 248.2 216.8 819.8 481.0 462.0 609.0 536.1 308.6 253.9 459.2 460.4 269.9 238.1 496.4 236.8 287.2 467.2 272.1 435.3 625.0 377.6 273.3 2470.8 410.1 404.5 301.5 429.7 291.4 329.0 239.8 503.5 200.3 269.1 2005.8 410.4 363.8 440.6 454.4 1556.8 1350.5 706.1 1094.6 666.5 696.6 1236.3 1097.5 1184.9 1999.1 2407.5 1409.9 823.0 903.4 212.7 1069.7 1042.4 748.8 1671.0 1812.3 2189.4 1196.4 1265.1 1172.0 924.4 926.2 496.8 1351.5 924.0 764.0 739.7 1537.8 1305.0 2816.1 1233.3 451.0 615.0 336.5 1554.5 1130.0 709.6 1119.5 1741.0 1302.3 855.9 413.5 1156.1 930.7 1261.4 1061.1 497.2 830.0 953.3 977.8 542.7 1452.6 224.4 1003.2 778.2 1068.0 914.6 703.1 1631.7 653.4 285.7 1327.8 2153.1 821.2 784.9 1708.8 2304.1 2375.2 824.6 2402.3 845.7 863.3 820.0 808.0 2656.1 800.9 570.5 703.0 934.3 1387.7 2165.7 482.0 1106.3 4679.5 446.2 480.2 476.5 541.9 481.0 462.0 459.2 460.4 467.2 429.7 503.5 454.4 311.5 134.6 204.2 34.6 290.6 684.8 553.8 1756.4 414.9 284.6 294.3 303.3 552.5 391.7 673.0 389.9 110.5 1017.0 278.2 850.3 1508.5 1361.5 203.0 280.8 307.0 352.0 425.5 243.3 38.4 786.5 1824.0 386.5 408.3 343.9 362.8 364.8 276.6 547.3 937.3 297.8 33.7 567.2 1151.5 386.7 750.4 683.5 279.0 482.8 674.1 18.7 1129.8 739.6 312.0 17.1 26.7 1081.5 889.4 263.3 427.9 556.2 1595.9 1642.7 401.2 298.0 197.2 270.5 551.3 14.9 79.0 690.4 615.9 1530.4 352.9 869.2 827.0 652.5 TSEN2 "MGC2776, SEN2, SEN2L" ENSG00000154743 "TRNA splicing endonuclease subunit 2" Q8NCE0 3 12484421-12541549 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "mRNA processing, tRNA processing" Lyase "Neurodegeneration, Pontocerebellar hypoplasia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 43.8;Excitatory neurons: 42.8;Inhibitory neurons: 46.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027120, HPA027125, HPA027268" Approved Supported Nucleoplasm,Centrosome,Cytosol NA NA "Cluster 30: Non-specific - Translation" "Cluster 72: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" Nucleoplasm "Centrosome, Cytosol" "HPA027120: AB_10600197, HPA027125: AB_10601896, HPA027268: AB_10601347" "unprognostic (5.58e-2)" "unprognostic (4.49e-1)" "unprognostic (1.49e-1)" "unprognostic (3.71e-2)" "unprognostic (9.59e-2)" "unprognostic (1.13e-1)" "prognostic unfavorable (1.13e-5)" "unprognostic (1.42e-1)" "unprognostic (5.66e-2)" "unprognostic (1.28e-1)" "unprognostic (2.71e-1)" "unprognostic (6.15e-2)" "unprognostic (1.41e-2)" "unprognostic (6.99e-2)" "unprognostic (4.90e-2)" "unprognostic (6.06e-2)" "prognostic favorable (3.49e-4)" 8.9 9.4 3.4 1.1 3.9 0.3 8.9 4.4 4.8 11.5 3.7 11.5 1.4 10.9 2.6 8.6 12.0 1.8 15.5 3.5 3.7 10.2 8.5 6.0 2.2 3.6 3.5 14.2 12.1 3.2 10.9 0.9 3.6 10.0 2.3 3.4 6.7 3.2 15.9 8.3 6.9 3.2 3.3 6.6 9.7 6.7 3.9 2.6 9.0 3.8 2.2 11.5 9.7 3.8 6.2 11.8 5.5 7.4 6.3 7.7 7.6 5.8 4.3 6.6 5.1 4.2 5.2 5.5 3.3 4.0 5.8 5.8 7.8 9.4 5.4 5.5 9.8 5.1 9.1 5.7 5.4 9.3 2.1 4.9 11.2 10.1 9.7 3.3 4.7 8.8 10.7 3.4 6.5 11.9 9.6 6.1 6.5 10.5 13.5 4.6 2.3 13.5 9.9 4.8 1.5 4.5 6.7 5.0 4.8 3.1 10.1 5.1 4.5 4.2 3.9 4.7 9.7 3.1 8.6 6.2 5.6 11.8 5.4 0.6 1.9 0.0 2.7 1.6 4.4 3.7 4.6 3.8 2.3 3.2 6.2 5.1 0.4 2.5 1.7 3.4 1.6 2.6 3.4 3.9 4.4 4.8 3.5 3.7 3.6 3.5 3.6 3.3 3.9 3.8 5.5 3.2 3.3 26.1 8.9 2.9 11.2 5.6 13.1 28.1 3.7 4.3 7.0 10.0 3.8 11.0 43.8 8.8 2.6 9.2 1.9 6.2 1.6 7.1 7.4 6.2 4.2 8.4 42.8 4.2 4.3 5.7 13.7 3.7 5.1 17.7 3.6 5.0 4.6 10.1 46.4 5.2 4.1 3.5 1.7 2.8 9.0 3.6 3.6 16.9 2.4 8.0 6.2 19.1 31.8 4.5 5.0 10.1 3.8 6.2 2.3 6.9 11.1 34.1 6.6 7.9 6.3 14.0 23.0 7.1 4.8 1.9 4.6 15.3 8.4 8.0 TSEN34 "LENG5, SEN34, SEN34L" ENSG00000170892 "TRNA splicing endonuclease subunit 34" Q9BSV6 19 54189938-54194536 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "mRNA processing, tRNA processing" Lyase "Disease variant, Neurodegeneration, Pontocerebellar hypoplasia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 6 "basophil: 5.0;eosinophil: 1.9;neutrophil: 4.8" "Lineage enriched" "Detected in single" 8 "granulocytes: 5.0" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041111, HPA048208" Approved Supported Nucleoplasm NA NA "Cluster 34: Basophils - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm "HPA041111: AB_10794263, HPA048208: AB_2680313" "unprognostic (3.24e-2)" "unprognostic (2.95e-2)" "unprognostic (1.59e-1)" "unprognostic (3.88e-2)" "unprognostic (3.48e-2)" "unprognostic (4.82e-2)" "prognostic unfavorable (1.44e-7)" "unprognostic (2.38e-1)" "unprognostic (7.35e-2)" "unprognostic (1.51e-1)" "unprognostic (5.04e-3)" "unprognostic (8.98e-2)" "unprognostic (4.55e-3)" "unprognostic (2.02e-3)" "unprognostic (1.81e-1)" "unprognostic (2.81e-1)" "unprognostic (1.12e-1)" 28.5 68.2 2.2 1.3 1.8 1.3 29.5 2.4 2.4 38.8 1.8 34.7 1.1 37.1 1.9 41.0 37.8 1.5 26.3 2.1 1.7 39.1 41.3 31.5 1.3 2.2 1.7 47.9 43.0 1.8 36.0 1.3 2.0 36.2 1.3 2.0 34.0 1.9 26.7 40.5 27.7 1.2 1.3 44.1 34.3 45.0 1.7 0.5 30.9 1.8 0.7 38.9 34.2 2.2 3.3 1.7 2.5 3.1 1.3 2.0 3.9 0.6 1.0 0.9 1.7 2.1 1.1 1.1 0.0 0.9 2.5 2.5 2.6 2.3 1.4 1.1 6.2 1.0 1.1 2.0 0.5 1.1 1.1 1.9 1.1 2.0 1.3 0.9 1.3 0.0 1.7 0.9 2.4 1.4 0.4 0.2 1.5 2.9 1.1 1.4 2.6 0.7 3.4 2.4 0.1 1.7 0.0 3.5 3.0 2.5 2.6 3.1 1.1 0.2 2.8 2.7 3.4 1.4 1.9 0.9 2.6 1.3 1.2 5.0 0.6 1.9 0.2 0.5 0.4 0.1 0.3 0.1 0.3 0.4 0.4 0.2 4.8 0.0 0.3 0.4 0.0 0.2 2.2 1.8 2.4 2.4 2.1 1.7 2.2 1.7 2.0 1.3 1.7 2.2 33.1 12.8 27.7 6.8 28.2 73.5 92.0 137.7 67.2 35.4 62.9 60.8 11.8 52.9 60.9 44.1 29.2 102.5 45.4 58.8 95.9 68.7 24.0 39.4 37.0 32.5 76.8 13.7 3.8 59.7 98.2 47.5 19.9 35.3 26.6 47.7 35.7 40.6 57.8 16.8 4.9 103.7 122.1 37.0 53.6 17.2 67.7 45.0 46.2 1.0 51.8 81.9 18.6 6.0 5.9 50.4 55.9 66.5 27.6 79.8 57.8 110.5 70.0 48.9 59.2 38.7 60.8 40.1 77.2 56.7 70.2 111.0 32.8 100.3 66.5 62.3 TYW1 "FLJ10900, MGC23001, MGC60291, RSAFD1, TYW1A, YPL207W" ENSG00000198874 "TRNA-yW synthesizing protein 1 homolog" Q9NV66 7 66995173-67239519 "Enzymes, Predicted membrane proteins" "tRNA processing" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 57.8;Oligodendrocytes: 58.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "HPA013568, HPA014118, HPA015535, HPA043136, HPA047029, HPA047052, HPA052097" Approved Approved "Nucleoplasm,Nucleoli,Nucleoli rim" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" "Nucleoplasm, Nucleoli, Nucleoli rim" "HPA013568: AB_2668852, HPA014118: AB_2668941, HPA015535: AB_1856487, HPA043136: AB_2678333, HPA047029: AB_2679909, HPA047052: AB_2679918, HPA052097: AB_2681723" "unprognostic (1.53e-1)" "unprognostic (5.49e-3)" "unprognostic (1.62e-1)" "unprognostic (3.05e-2)" "unprognostic (1.84e-2)" "unprognostic (2.20e-1)" "unprognostic (1.83e-2)" "unprognostic (1.79e-1)" "unprognostic (1.47e-1)" "prognostic unfavorable (1.73e-4)" "unprognostic (4.86e-2)" "unprognostic (1.30e-1)" "unprognostic (1.85e-2)" "unprognostic (4.70e-2)" "unprognostic (1.60e-1)" "unprognostic (1.36e-2)" "unprognostic (1.79e-2)" 7.7 10.8 5.5 8.1 5.9 9.1 10.0 6.6 7.6 13.0 8.8 9.0 9.5 9.2 9.7 6.6 10.1 7.1 7.9 5.6 6.4 8.8 12.0 7.2 9.8 6.4 5.8 12.2 7.3 13.1 6.9 8.4 6.1 9.8 10.7 9.0 7.1 9.5 15.6 7.9 7.8 9.2 5.6 7.7 7.7 8.1 5.7 10.4 12.8 8.4 9.4 8.5 8.7 7.3 16.3 20.5 12.1 24.9 17.4 12.0 13.8 16.8 12.9 12.9 12.0 23.3 20.2 28.1 25.2 15.4 18.6 18.4 24.9 20.3 18.4 22.1 24.1 11.9 17.1 15.6 17.7 27.7 15.1 12.4 20.3 17.5 27.0 10.6 13.0 20.9 32.3 16.0 15.6 15.7 18.1 23.4 21.1 27.2 18.8 19.7 16.6 34.8 17.4 16.4 18.2 18.3 20.4 38.4 17.6 22.7 26.6 19.6 14.0 15.0 10.8 11.8 23.3 16.1 25.7 33.2 12.1 25.9 20.8 2.4 7.4 3.9 8.5 7.7 11.2 8.3 8.8 9.5 8.8 9.8 10.8 11.7 1.8 11.1 10.0 6.7 6.8 6.2 5.5 5.9 6.6 7.6 5.6 6.4 6.4 5.8 6.1 5.6 5.7 7.3 10.0 6.4 15.3 39.2 18.2 10.5 5.3 10.0 17.1 12.0 11.4 11.7 9.5 10.0 7.6 11.0 4.2 18.6 11.7 7.8 0.0 7.8 7.3 10.9 18.0 8.8 4.8 12.6 57.8 6.9 13.1 11.0 12.8 10.9 34.2 9.1 6.1 14.2 7.7 3.3 53.4 12.3 12.2 7.1 11.2 4.5 8.4 10.3 8.8 43.1 10.0 6.8 10.3 50.3 58.7 7.1 4.0 8.2 18.0 6.2 4.9 2.4 9.6 11.5 19.7 11.2 10.4 23.9 23.4 15.6 16.9 15.2 17.1 10.2 11.4 3.3 TYW1B "LINC00069, MGC87315, NCRNA00069, RSAFD2" ENSG00000277149 "TRNA-yW synthesizing protein 1 homolog B" Q6NUM6 7 72558744-72828200 "Enzymes, Predicted membrane proteins" "tRNA processing" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 21.9;Excitatory neurons: 47.4;Inhibitory neurons: 27.7;Oligodendrocyte precursor cells: 23.1;Oligodendrocytes: 41.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "HPA013568, HPA014118, HPA043136, HPA047029, HPA047052, HPA052097" Approved Approved "Nucleoplasm,Nucleoli,Nucleoli rim" NA NA "Cluster 37: B-cells - Transcription" "Cluster 46: Fibroblasts - ECM organization" "Cluster 1: K-562 - Erythropoiesis" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoplasm, Nucleoli, Nucleoli rim" "HPA013568: AB_2668852, HPA014118: AB_2668941, HPA043136: AB_2678333, HPA047029: AB_2679909, HPA047052: AB_2679918, HPA052097: AB_2681723" "unprognostic (2.61e-1)" "unprognostic (3.54e-1)" "unprognostic (1.92e-1)" "unprognostic (1.64e-1)" "unprognostic (1.91e-2)" "unprognostic (6.22e-3)" "unprognostic (3.88e-2)" "unprognostic (1.64e-2)" "unprognostic (1.19e-2)" "unprognostic (8.96e-3)" "unprognostic (5.78e-2)" "unprognostic (2.90e-2)" "unprognostic (4.33e-4)" "unprognostic (1.02e-1)" "unprognostic (2.41e-1)" "unprognostic (1.85e-1)" "unprognostic (5.90e-2)" 2.3 1.8 2.4 1.3 2.3 2.9 2.5 2.0 2.6 4.1 6.9 1.8 1.0 2.4 2.9 2.0 2.3 0.9 1.5 2.5 2.3 1.8 4.5 1.6 1.7 1.8 1.4 5.3 2.0 1.7 2.1 1.8 1.9 2.6 2.4 2.5 1.8 2.7 3.4 2.6 1.7 1.3 1.5 1.9 2.0 2.9 1.8 2.4 3.4 1.1 2.5 2.6 3.1 3.1 2.4 2.5 1.0 2.0 1.5 0.5 1.1 1.2 0.5 1.0 1.1 8.0 4.1 7.4 0.7 0.8 1.0 1.1 1.9 0.8 1.2 8.0 2.3 0.7 1.2 4.7 0.8 7.6 2.0 3.6 0.5 1.2 0.8 0.6 0.7 1.6 10.3 7.5 1.0 1.0 2.5 3.8 1.8 3.1 4.5 1.4 5.4 2.7 1.1 0.8 1.7 0.9 1.5 8.2 4.5 3.1 2.1 2.6 3.1 1.8 4.1 9.4 1.4 6.5 8.4 8.2 0.5 2.1 9.5 3.0 1.9 3.3 1.5 0.8 1.3 4.7 0.9 0.9 0.7 2.3 1.1 1.4 2.2 1.2 0.8 2.9 1.0 0.6 2.4 2.3 2.0 2.6 2.5 2.3 1.8 1.4 1.9 1.5 1.8 3.1 3.5 0.0 2.0 21.9 7.2 0.0 1.8 0.0 2.2 4.3 3.4 3.4 5.3 2.8 0.6 0.0 10.4 4.8 5.4 2.1 0.0 2.9 4.9 3.6 7.6 3.2 0.0 3.2 47.4 0.7 1.7 3.3 4.6 5.3 1.3 2.0 1.8 2.7 3.1 1.7 27.7 2.9 0.0 1.0 0.0 1.1 0.9 3.0 0.0 15.0 3.2 0.9 2.1 23.1 41.4 0.8 2.3 0.7 5.8 2.2 2.0 0.7 1.5 8.0 0.0 6.9 5.2 5.6 5.2 5.4 0.0 1.9 5.1 5.4 2.2 1.1 UMPS ENSG00000114491 "Uridine monophosphate synthetase" P11172 3 124730433-124749273 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Pyrimidine biosynthesis" "Decarboxylase, Glycosyltransferase, Lyase, Multifunctional enzyme, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 109.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036178, HPA036179" Uncertain Approved Cytosol NA NA 9200 "Cluster 26: Non-specific - Mitochondria" "Cluster 45: Intestine - Brush border" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Cytosol "HPA036178: AB_10673002, HPA036179: AB_10673615" "unprognostic (6.41e-2)" "unprognostic (6.70e-2)" "unprognostic (1.79e-2)" "unprognostic (1.13e-3)" "unprognostic (2.70e-1)" "unprognostic (1.72e-1)" "unprognostic (1.15e-3)" "unprognostic (5.51e-2)" "unprognostic (4.85e-3)" "unprognostic (1.43e-1)" "unprognostic (5.36e-2)" "prognostic unfavorable (9.20e-4)" "unprognostic (2.18e-2)" "unprognostic (1.58e-2)" "unprognostic (1.91e-1)" "unprognostic (4.61e-2)" "unprognostic (1.31e-1)" 1.3 1.4 2.5 1.2 2.5 1.3 1.8 2.8 2.9 1.0 1.1 2.3 2.0 1.3 1.0 2.0 1.8 0.7 0.8 2.6 1.8 1.8 2.6 0.9 1.4 2.8 2.1 1.9 2.1 1.5 0.8 0.7 2.3 1.4 1.6 1.8 1.3 0.7 3.1 2.3 2.1 1.1 2.0 2.6 1.8 0.9 2.3 1.8 1.1 0.7 1.7 0.8 1.0 3.5 1.4 4.4 5.1 2.1 2.9 3.4 5.4 7.9 2.4 3.1 2.6 3.8 2.1 4.0 8.2 3.0 7.9 9.0 7.1 2.4 5.0 4.4 4.2 8.2 3.0 2.7 2.6 8.7 6.0 3.8 2.3 1.8 3.9 1.9 1.2 8.2 3.7 1.9 2.3 3.5 10.8 1.7 12.1 3.9 2.7 7.4 6.0 3.3 2.4 2.5 4.0 2.6 11.3 4.2 4.3 3.7 4.1 3.1 15.4 2.5 5.2 7.4 3.2 8.0 12.5 12.1 2.8 3.4 2.6 5.9 10.3 5.5 14.0 11.3 12.4 17.0 9.2 12.1 14.6 24.3 13.9 10.8 0.7 12.8 9.3 11.0 12.4 11.9 2.5 2.5 2.8 2.9 2.6 1.8 2.8 2.1 2.3 2.0 2.3 3.5 9.6 6.4 11.5 6.5 11.2 15.8 24.5 41.3 18.8 8.3 8.9 12.3 6.2 20.0 22.8 9.2 4.2 66.8 13.2 9.0 29.4 29.8 3.2 10.9 18.2 15.2 9.6 16.2 11.0 30.5 35.0 12.7 14.3 12.1 12.0 22.8 7.9 31.4 22.0 5.0 12.0 10.3 20.3 7.0 5.9 4.4 13.7 8.3 3.6 10.3 18.0 11.0 13.4 15.6 12.2 23.4 8.6 13.9 10.4 14.6 14.0 25.9 22.1 9.1 13.1 13.3 17.1 23.2 32.1 20.6 19.0 109.2 11.0 29.5 17.8 21.1 URAD PRHOXNB ENSG00000183463 "Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase" A6NGE7 13 27977717-27988693 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Purine metabolism" "Decarboxylase, Lyase" "Evidence at transcript level" "Evidence at transcript level" "Tissue enriched" "Detected in some" 14 "intestine: 25.1" "Cell type enhanced" "Detected in some" "Distal enterocytes: 44.4;Intestinal goblet cells: 110.6;Paneth cells: 43.3;Proximal enterocytes: 196.3;Undifferentiated cells: 54.7" "Cancer enriched" "Detected in some" 15 "colorectal cancer: 7.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 12 "BEWO: 2.6;CACO-2: 2.4" HPA038972 Uncertain NA NA "Cluster 9: Intestine - Unknown function" "Cluster 39: CACO-2 - Unknown function" "Cluster 45: Enterocytes - Digestion" "HPA038972: AB_10671869" "unprognostic (2.00e-1)" "unprognostic (1.05e-1)" "unprognostic (5.21e-2)" 0.2 0.0 0.0 1.7 0.0 0.0 0.2 0.7 0.1 0.0 0.0 25.1 7.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.0 0.0 0.0 0.0 0.0 0.0 17.0 0.3 0.1 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.1 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 44.4 3.9 0.1 0.3 0.0 0.0 0.0 10.7 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 110.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.1 0.0 43.3 0.0 0.0 0.0 196.3 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.3 0.0 54.7 0.0 UROC1 "FLJ31300, HMFN0320" ENSG00000159650 "Urocanate hydratase 1" Q96N76 3 126481166-126517773 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Histidine metabolism" Lyase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 336 "liver: 116.6" "Cell type enriched" "Detected in some" 4 "Hepatocytes: 62.2" "Cancer enriched" "Detected in single" 100 "liver cancer: 12.1" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 8 "NB-4: 4.0" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA069863 Enhanced NA NA 670000 "Cluster 62: Liver - Hemostasis" "Cluster 24: NB-4 - Immune response" "Cluster 15: Hepatocytes - Hemostasis" "HPA069863: AB_2732143" "unprognostic (1.28e-1)" "unprognostic (2.74e-2)" "unprognostic (1.08e-1)" "unprognostic (7.43e-2)" "unprognostic (6.43e-2)" "unprognostic (1.43e-1)" "unprognostic (2.23e-3)" "unprognostic (2.95e-1)" "unprognostic (2.57e-2)" "unprognostic (7.71e-2)" "unprognostic (9.97e-2)" "unprognostic (3.04e-1)" "unprognostic (3.65e-5)" "unprognostic (3.97e-2)" "unprognostic (2.66e-1)" "unprognostic (5.52e-2)" 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.1 0.0 116.6 0.0 0.0 0.2 0.3 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.2 0.1 0.1 0.2 0.3 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 13.5 0.4 0.2 0.1 0.0 0.0 0.0 0.0 0.1 3.3 62.2 0.3 0.0 0.1 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 UROD ENSG00000126088 "Uroporphyrinogen decarboxylase" P06132 1 45010950-45015575 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Heme biosynthesis, Porphyrin biosynthesis" "Decarboxylase, Lyase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in all" 5 "Erythroid cells: 806.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "K-562: 420.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027468, HPA028668, HPA030350" Uncertain Supported Nucleoplasm,Cytosol NA NA 2600000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 1: K-562 - Erythropoiesis" "Cluster 6: Erythroid cells - Oxygen transport" "Nucleoplasm, Cytosol" "HPA027468: AB_1858654, HPA028668: AB_10603458, HPA030350: AB_2673440" "unprognostic (5.90e-2)" "unprognostic (2.94e-2)" "unprognostic (2.49e-1)" "unprognostic (9.61e-2)" "unprognostic (7.94e-2)" "unprognostic (1.96e-1)" "prognostic unfavorable (2.48e-4)" "unprognostic (2.31e-2)" "unprognostic (4.76e-2)" "unprognostic (6.75e-2)" "unprognostic (7.72e-3)" "unprognostic (3.92e-1)" "unprognostic (1.24e-1)" "unprognostic (4.68e-2)" "unprognostic (1.41e-1)" "unprognostic (8.73e-2)" "unprognostic (8.12e-2)" 51.7 120.1 72.0 25.5 73.9 199.0 48.2 72.0 79.3 40.8 77.2 49.3 29.2 46.9 54.7 34.2 49.2 30.8 70.6 73.1 74.5 58.0 100.9 34.8 35.2 72.1 73.4 51.1 45.1 115.0 42.6 39.4 73.6 35.1 30.1 24.7 61.4 44.2 75.9 31.7 30.7 54.7 72.9 37.8 38.5 44.8 73.6 44.0 54.0 83.8 36.1 40.3 32.7 73.8 66.0 42.5 67.0 89.1 113.4 107.7 31.8 87.4 209.8 163.9 125.2 59.9 32.3 46.4 82.3 122.8 116.3 31.1 127.2 153.6 116.9 42.9 133.4 245.4 95.4 200.7 132.4 79.0 42.6 115.1 97.6 154.1 132.3 121.8 208.9 92.9 420.8 48.5 157.6 53.5 49.9 62.9 104.1 51.5 145.9 76.5 96.5 69.9 141.7 54.4 73.9 57.3 89.1 63.9 134.3 73.7 50.8 77.6 137.5 96.9 71.6 34.2 130.5 49.4 60.1 38.1 141.0 117.6 47.2 72.3 111.9 65.5 57.4 81.5 58.8 84.9 69.2 56.7 149.7 81.9 63.6 58.0 20.1 87.4 50.9 102.3 88.7 122.1 72.0 73.9 72.0 79.3 73.1 74.5 72.1 73.4 73.6 72.9 73.6 73.8 25.8 44.8 38.0 7.8 25.4 22.9 35.8 101.4 43.9 27.3 31.0 37.1 74.4 41.5 45.3 27.6 16.7 98.6 22.1 21.4 90.1 73.5 8.1 20.3 30.7 42.7 18.0 806.8 9.4 63.7 54.6 57.1 17.3 21.2 52.6 20.4 38.6 98.5 101.8 13.5 6.7 20.2 73.2 37.9 29.4 16.2 79.6 38.5 48.0 5.6 103.6 89.7 24.7 7.1 7.3 51.2 23.7 56.1 36.8 15.9 32.7 134.5 32.9 25.3 39.5 29.4 75.0 37.3 42.3 31.6 24.7 49.8 23.3 72.7 20.9 29.1 UROS ENSG00000188690 "Uroporphyrinogen III synthase" P10746 10 125784980-125823258 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Heme biosynthesis, Porphyrin biosynthesis" Lyase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Erythroid cells: 231.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044038 Approved Approved Nucleoplasm,Cytosol NA NA 69000 "Cluster 24: B-cells - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 36: HEL - Hemostasis" "Cluster 6: Erythroid cells - Oxygen transport" Nucleoplasm Cytosol "HPA044038: AB_10966692" "unprognostic (8.86e-2)" "unprognostic (7.64e-2)" "unprognostic (2.77e-1)" "unprognostic (7.19e-2)" "unprognostic (1.90e-1)" "unprognostic (2.41e-1)" "unprognostic (1.08e-1)" "unprognostic (5.82e-2)" "unprognostic (1.27e-1)" "unprognostic (4.35e-3)" "unprognostic (4.23e-3)" "unprognostic (2.00e-2)" "prognostic unfavorable (6.27e-4)" "unprognostic (1.58e-1)" "unprognostic (1.50e-1)" "unprognostic (1.68e-1)" "unprognostic (3.93e-1)" 27.9 41.3 54.1 13.4 55.3 67.5 26.9 40.6 64.5 15.9 33.0 29.9 20.9 21.4 56.9 24.9 19.3 15.6 73.2 56.3 45.8 40.7 59.7 20.5 18.8 41.6 48.1 22.5 32.9 30.0 29.9 11.3 43.5 27.4 16.5 26.2 29.6 19.1 83.8 23.0 24.2 18.1 40.2 28.0 29.6 31.2 51.8 18.6 32.5 80.0 19.1 27.3 17.0 47.8 45.5 56.3 29.8 74.9 38.5 42.2 51.9 51.4 94.5 39.0 34.6 22.9 54.0 58.4 24.7 72.9 24.3 23.5 18.5 43.1 31.3 78.1 39.9 125.3 27.9 40.1 67.3 50.7 29.7 59.3 20.7 25.8 66.0 47.5 34.4 48.5 24.4 54.1 63.5 65.2 51.2 72.8 37.7 31.8 54.0 33.1 34.1 37.3 53.9 28.2 26.2 46.8 51.6 41.8 80.7 30.8 40.4 59.1 33.8 52.3 19.6 38.1 48.2 50.7 36.8 40.6 75.6 23.1 26.3 4.9 31.9 4.6 30.1 33.1 33.9 30.1 29.3 38.6 53.5 37.5 38.1 29.6 2.1 53.6 31.9 25.3 29.8 38.1 54.1 55.3 40.6 64.5 56.3 45.8 41.6 48.1 43.5 40.2 51.8 47.8 19.0 19.2 23.1 20.5 34.3 9.3 12.0 31.8 9.6 49.3 36.2 39.5 70.5 40.0 28.6 36.8 45.9 60.8 36.3 19.1 101.8 59.7 57.0 11.2 25.5 22.2 14.5 231.5 23.9 59.6 47.4 33.3 23.9 16.9 11.4 112.3 28.2 53.4 79.3 47.1 25.2 25.6 40.7 47.8 20.8 123.7 35.8 31.6 62.2 9.4 58.7 77.0 69.0 13.6 29.6 42.7 15.8 40.6 46.9 27.3 52.9 142.6 20.4 42.3 6.6 22.8 36.7 55.7 100.9 28.5 12.8 20.0 37.8 55.0 38.8 21.3 UXS1 "FLJ23591, SDR6E1, UGD" ENSG00000115652 "UDP-glucuronate decarboxylase 1" Q8NBZ7 2 106093308-106194301 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Decarboxylase, Lyase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RPTEC TERT1: 323.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008825 Uncertain "Intracellular and membrane" NA NA 24000 "Cluster 20: T-cells - T-cell receptor" "Cluster 7: Kidney - Transmembrane transport" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "HPA008825: AB_1858708" "unprognostic (4.08e-1)" "unprognostic (1.52e-1)" "unprognostic (1.99e-1)" "unprognostic (3.63e-2)" "unprognostic (3.92e-2)" "prognostic unfavorable (5.45e-4)" "prognostic unfavorable (1.38e-4)" "unprognostic (3.20e-3)" "unprognostic (2.07e-1)" "prognostic favorable (7.94e-4)" "unprognostic (3.95e-2)" "unprognostic (1.40e-2)" "unprognostic (8.46e-2)" "unprognostic (3.96e-2)" "unprognostic (6.18e-2)" "unprognostic (1.86e-2)" "unprognostic (5.32e-2)" 16.3 17.6 20.4 25.0 18.7 40.4 15.3 30.4 29.3 19.6 20.6 21.7 15.5 24.3 33.1 24.1 29.2 19.6 29.3 25.9 20.3 60.0 15.7 46.0 27.9 15.0 23.0 24.4 15.8 37.3 16.3 54.6 19.3 23.2 24.0 10.5 14.6 25.9 31.9 14.0 14.3 21.4 18.5 25.0 26.2 31.9 31.0 22.2 30.0 28.6 30.4 29.5 18.3 23.7 66.5 48.8 50.9 39.0 88.4 65.2 110.2 71.4 66.9 49.9 61.5 96.9 110.4 12.0 87.0 74.1 111.2 32.8 22.6 58.2 54.5 64.2 40.5 37.0 21.4 110.6 34.9 30.5 39.0 42.8 63.8 50.3 33.5 57.5 52.5 22.8 22.1 28.5 103.6 46.8 34.3 66.8 60.1 64.2 65.4 70.3 38.6 34.3 323.0 60.9 16.7 19.0 51.5 45.7 44.3 67.7 17.0 93.7 48.0 55.1 58.5 45.4 45.4 34.4 51.4 17.9 55.0 70.1 103.8 11.3 24.7 28.5 23.1 20.8 25.7 15.3 64.3 41.4 19.1 30.5 68.8 49.1 6.1 37.5 16.0 13.5 130.4 44.3 20.4 18.7 30.4 29.3 25.9 20.3 15.0 23.0 19.3 18.5 31.0 23.7 15.4 89.8 88.8 18.9 22.1 16.8 26.8 117.3 14.8 9.9 11.6 10.5 18.7 17.2 61.6 86.5 4.2 71.2 17.7 20.5 50.9 46.9 80.2 41.5 19.3 25.5 6.6 12.0 49.8 25.0 74.1 34.2 16.8 40.6 29.8 13.1 10.8 15.0 33.2 8.4 37.5 15.6 34.6 20.1 12.5 18.5 15.2 33.9 14.2 33.7 56.2 10.8 18.6 24.1 11.7 30.4 16.2 12.8 10.2 35.7 9.6 17.5 38.8 7.9 19.7 19.0 35.1 17.0 81.6 22.6 13.2 24.6 33.7 51.6 18.0 19.8