Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific nTPM" "RNA single cell type specificity" "RNA single cell type distribution" "RNA single cell type specificity score" "RNA single cell type specific nTPM" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific nTPM" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific nTPM" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific nTPM" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific nTPM" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific nTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific nTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "CCD Protein" "CCD Transcript" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Blood expression cluster" "Tissue expression cluster" "Cell line expression cluster" "Single cell expression cluster" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [nTPM]" "Tissue RNA - adrenal gland [nTPM]" "Tissue RNA - amygdala [nTPM]" "Tissue RNA - appendix [nTPM]" "Tissue RNA - basal ganglia [nTPM]" "Tissue RNA - bone marrow [nTPM]" "Tissue RNA - breast [nTPM]" "Tissue RNA - cerebellum [nTPM]" "Tissue RNA - cerebral cortex [nTPM]" "Tissue RNA - cervix [nTPM]" "Tissue RNA - choroid plexus [nTPM]" "Tissue RNA - colon [nTPM]" "Tissue RNA - duodenum [nTPM]" "Tissue RNA - endometrium 1 [nTPM]" "Tissue RNA - epididymis [nTPM]" "Tissue RNA - esophagus [nTPM]" "Tissue RNA - fallopian tube [nTPM]" "Tissue RNA - gallbladder [nTPM]" "Tissue RNA - heart muscle [nTPM]" "Tissue RNA - hippocampal formation [nTPM]" "Tissue RNA - hypothalamus [nTPM]" "Tissue RNA - kidney [nTPM]" "Tissue RNA - liver [nTPM]" "Tissue RNA - lung [nTPM]" "Tissue RNA - lymph node [nTPM]" "Tissue RNA - medulla oblongata [nTPM]" "Tissue RNA - midbrain [nTPM]" "Tissue RNA - ovary [nTPM]" "Tissue RNA - pancreas [nTPM]" "Tissue RNA - parathyroid gland [nTPM]" "Tissue RNA - pituitary gland [nTPM]" "Tissue RNA - placenta [nTPM]" "Tissue RNA - pons [nTPM]" "Tissue RNA - prostate [nTPM]" "Tissue RNA - rectum [nTPM]" "Tissue RNA - retina [nTPM]" "Tissue RNA - salivary gland [nTPM]" "Tissue RNA - seminal vesicle [nTPM]" "Tissue RNA - skeletal muscle [nTPM]" "Tissue RNA - skin 1 [nTPM]" "Tissue RNA - small intestine [nTPM]" "Tissue RNA - smooth muscle [nTPM]" "Tissue RNA - spinal cord [nTPM]" "Tissue RNA - spleen [nTPM]" "Tissue RNA - stomach 1 [nTPM]" "Tissue RNA - testis [nTPM]" "Tissue RNA - thalamus [nTPM]" "Tissue RNA - thymus [nTPM]" "Tissue RNA - thyroid gland [nTPM]" "Tissue RNA - tongue [nTPM]" "Tissue RNA - tonsil [nTPM]" "Tissue RNA - urinary bladder [nTPM]" "Tissue RNA - vagina [nTPM]" "Tissue RNA - white matter [nTPM]" "Cell RNA - A-431 [nTPM]" "Cell RNA - A549 [nTPM]" "Cell RNA - AF22 [nTPM]" "Cell RNA - AN3-CA [nTPM]" "Cell RNA - ASC diff [nTPM]" "Cell RNA - ASC TERT1 [nTPM]" "Cell RNA - BEWO [nTPM]" "Cell RNA - BJ [nTPM]" "Cell RNA - BJ hTERT+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]" "Cell RNA - CACO-2 [nTPM]" "Cell RNA - CAPAN-2 [nTPM]" "Cell RNA - Daudi [nTPM]" "Cell RNA - EFO-21 [nTPM]" "Cell RNA - fHDF/TERT166 [nTPM]" "Cell RNA - GAMG [nTPM]" "Cell RNA - HaCaT [nTPM]" "Cell RNA - HAP1 [nTPM]" "Cell RNA - HBEC3-KT [nTPM]" "Cell RNA - HBF TERT88 [nTPM]" "Cell RNA - HDLM-2 [nTPM]" "Cell RNA - HEK 293 [nTPM]" "Cell RNA - HEL [nTPM]" "Cell RNA - HeLa [nTPM]" "Cell RNA - Hep G2 [nTPM]" "Cell RNA - HHSteC [nTPM]" "Cell RNA - HL-60 [nTPM]" "Cell RNA - HMC-1 [nTPM]" "Cell RNA - HSkMC [nTPM]" "Cell RNA - hTCEpi [nTPM]" "Cell RNA - hTEC/SVTERT24-B [nTPM]" "Cell RNA - hTERT-HME1 [nTPM]" "Cell RNA - hTERT-RPE1 [nTPM]" "Cell RNA - HUVEC TERT2 [nTPM]" "Cell RNA - JURKAT [nTPM]" "Cell RNA - K-562 [nTPM]" "Cell RNA - Karpas-707 [nTPM]" "Cell RNA - LHCN-M2 [nTPM]" "Cell RNA - MCF7 [nTPM]" "Cell RNA - MOLT-4 [nTPM]" "Cell RNA - NB-4 [nTPM]" "Cell RNA - NTERA-2 [nTPM]" "Cell RNA - OE19 [nTPM]" "Cell RNA - PC-3 [nTPM]" "Cell RNA - REH [nTPM]" "Cell RNA - RH-30 [nTPM]" "Cell RNA - RPMI-8226 [nTPM]" "Cell RNA - RPTEC TERT1 [nTPM]" "Cell RNA - RT4 [nTPM]" "Cell RNA - SCLC-21H [nTPM]" "Cell RNA - SH-SY5Y [nTPM]" "Cell RNA - SiHa [nTPM]" "Cell RNA - SK-BR-3 [nTPM]" "Cell RNA - SK-MEL-30 [nTPM]" "Cell RNA - SuSa [nTPM]" "Cell RNA - T-47d [nTPM]" "Cell RNA - THP-1 [nTPM]" "Cell RNA - TIME [nTPM]" "Cell RNA - U-138 MG [nTPM]" "Cell RNA - U-2 OS [nTPM]" "Cell RNA - U-2197 [nTPM]" "Cell RNA - U-251 MG [nTPM]" "Cell RNA - U-266/70 [nTPM]" "Cell RNA - U-266/84 [nTPM]" "Cell RNA - U-698 [nTPM]" "Cell RNA - U-87 MG [nTPM]" "Cell RNA - U-937 [nTPM]" "Cell RNA - WM-115 [nTPM]" "Blood RNA - basophil [nTPM]" "Blood RNA - classical monocyte [nTPM]" "Blood RNA - eosinophil [nTPM]" "Blood RNA - gdT-cell [nTPM]" "Blood RNA - intermediate monocyte [nTPM]" "Blood RNA - MAIT T-cell [nTPM]" "Blood RNA - memory B-cell [nTPM]" "Blood RNA - memory CD4 T-cell [nTPM]" "Blood RNA - memory CD8 T-cell [nTPM]" "Blood RNA - myeloid DC [nTPM]" "Blood RNA - naive B-cell [nTPM]" "Blood RNA - naive CD4 T-cell [nTPM]" "Blood RNA - naive CD8 T-cell [nTPM]" "Blood RNA - neutrophil [nTPM]" "Blood RNA - NK-cell [nTPM]" "Blood RNA - non-classical monocyte [nTPM]" "Blood RNA - plasmacytoid DC [nTPM]" "Blood RNA - T-reg [nTPM]" "Blood RNA - total PBMC [nTPM]" "Brain RNA - amygdala [nTPM]" "Brain RNA - basal ganglia [nTPM]" "Brain RNA - cerebellum [nTPM]" "Brain RNA - cerebral cortex [nTPM]" "Brain RNA - hippocampal formation [nTPM]" "Brain RNA - hypothalamus [nTPM]" "Brain RNA - medulla oblongata [nTPM]" "Brain RNA - midbrain [nTPM]" "Brain RNA - pons [nTPM]" "Brain RNA - spinal cord [nTPM]" "Brain RNA - thalamus [nTPM]" "Brain RNA - white matter [nTPM]" "Single Cell Type RNA - Adipocytes [nTPM]" "Single Cell Type RNA - Alveolar cells type 1 [nTPM]" "Single Cell Type RNA - Alveolar cells type 2 [nTPM]" "Single Cell Type RNA - Astrocytes [nTPM]" "Single Cell Type RNA - B-cells [nTPM]" "Single Cell Type RNA - Basal keratinocytes [nTPM]" "Single Cell Type RNA - Basal prostatic cells [nTPM]" "Single Cell Type RNA - Basal respiratory cells [nTPM]" "Single Cell Type RNA - Basal squamous epithelial cells [nTPM]" "Single Cell Type RNA - Bipolar cells [nTPM]" "Single Cell Type RNA - Breast glandular cells [nTPM]" "Single Cell Type RNA - Breast myoepithelial cells [nTPM]" "Single Cell Type RNA - Cardiomyocytes [nTPM]" "Single Cell Type RNA - Cholangiocytes [nTPM]" "Single Cell Type RNA - Club cells [nTPM]" "Single Cell Type RNA - Collecting duct cells [nTPM]" "Single Cell Type RNA - Cone photoreceptor cells [nTPM]" "Single Cell Type RNA - Cytotrophoblasts [nTPM]" "Single Cell Type RNA - dendritic cells [nTPM]" "Single Cell Type RNA - Distal enterocytes [nTPM]" "Single Cell Type RNA - Distal tubular cells [nTPM]" "Single Cell Type RNA - Ductal cells [nTPM]" "Single Cell Type RNA - Early spermatids [nTPM]" "Single Cell Type RNA - Endometrial ciliated cells [nTPM]" "Single Cell Type RNA - Endometrial stromal cells [nTPM]" "Single Cell Type RNA - Endothelial cells [nTPM]" "Single Cell Type RNA - Enteroendocrine cells [nTPM]" "Single Cell Type RNA - Erythroid cells [nTPM]" "Single Cell Type RNA - Excitatory neurons [nTPM]" "Single Cell Type RNA - Exocrine glandular cells [nTPM]" "Single Cell Type RNA - Extravillous trophoblasts [nTPM]" "Single Cell Type RNA - Fibroblasts [nTPM]" "Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]" "Single Cell Type RNA - Glandular and luminal cells [nTPM]" "Single Cell Type RNA - granulocytes [nTPM]" "Single Cell Type RNA - Granulosa cells [nTPM]" "Single Cell Type RNA - Hepatic stellate cells [nTPM]" "Single Cell Type RNA - Hepatocytes [nTPM]" "Single Cell Type RNA - Hofbauer cells [nTPM]" "Single Cell Type RNA - Horizontal cells [nTPM]" "Single Cell Type RNA - Inhibitory neurons [nTPM]" "Single Cell Type RNA - Intestinal goblet cells [nTPM]" "Single Cell Type RNA - Ionocytes [nTPM]" "Single Cell Type RNA - Kupffer cells [nTPM]" "Single Cell Type RNA - Langerhans cells [nTPM]" "Single Cell Type RNA - Late spermatids [nTPM]" "Single Cell Type RNA - Leydig cells [nTPM]" "Single Cell Type RNA - Macrophages [nTPM]" "Single Cell Type RNA - Melanocytes [nTPM]" "Single Cell Type RNA - Microglial cells [nTPM]" "Single Cell Type RNA - monocytes [nTPM]" "Single Cell Type RNA - Muller glia cells [nTPM]" "Single Cell Type RNA - NK-cells [nTPM]" "Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]" "Single Cell Type RNA - Oligodendrocytes [nTPM]" "Single Cell Type RNA - Pancreatic endocrine cells [nTPM]" "Single Cell Type RNA - Paneth cells [nTPM]" "Single Cell Type RNA - Peritubular cells [nTPM]" "Single Cell Type RNA - Plasma cells [nTPM]" "Single Cell Type RNA - Prostatic glandular cells [nTPM]" "Single Cell Type RNA - Proximal enterocytes [nTPM]" "Single Cell Type RNA - Proximal tubular cells [nTPM]" "Single Cell Type RNA - Respiratory ciliated cells [nTPM]" "Single Cell Type RNA - Rod photoreceptor cells [nTPM]" "Single Cell Type RNA - Sertoli cells [nTPM]" "Single Cell Type RNA - Skeletal myocytes [nTPM]" "Single Cell Type RNA - Smooth muscle cells [nTPM]" "Single Cell Type RNA - Spermatocytes [nTPM]" "Single Cell Type RNA - Spermatogonia [nTPM]" "Single Cell Type RNA - Squamous epithelial cells [nTPM]" "Single Cell Type RNA - Suprabasal keratinocytes [nTPM]" "Single Cell Type RNA - Syncytiotrophoblasts [nTPM]" "Single Cell Type RNA - T-cells [nTPM]" "Single Cell Type RNA - Theca cells [nTPM]" "Single Cell Type RNA - Undifferentiated cells [nTPM]" "Single Cell Type RNA - Urothelial cells [nTPM]" ACE "ACE1, CD143, DCP1" ENSG00000159640 "Angiotensin I converting enzyme" P12821 17 63477061-63498380 "Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 265.1;testis: 101.9" "Group enriched" "Detected in many" 20 "Early spermatids: 543.6;Late spermatids: 1322.9;Proximal enterocytes: 1172.8" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "basal ganglia: 8.1" "Immune cell enhanced" "Detected in single" "memory B-cell: 1.0" "Low lineage specificity" "Detected in single" "Group enriched" "Detected in many" 4 "ASC TERT1: 63.3;HUVEC TERT2: 33.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002426, CAB002921, HPA029298, HPA069790" Enhanced Approved Vesicles "Secreted to blood" NA NA 104000000 170000000 "Cluster 43: B-cells - Humoral immune response" "Cluster 56: Intestine - Transmembrane transport" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 45: Enterocytes - Digestion" Vesicles "CAB002426: AB_442052, CAB002921: , HPA029298: AB_10960255, HPA069790: AB_2686197" "unprognostic (4.72e-2)" "unprognostic (4.16e-1)" "unprognostic (1.93e-3)" "unprognostic (6.06e-2)" "unprognostic (2.78e-1)" "unprognostic (1.35e-2)" "unprognostic (4.37e-1)" "unprognostic (1.54e-1)" "unprognostic (1.56e-1)" "unprognostic (1.25e-2)" "unprognostic (3.13e-2)" "unprognostic (2.38e-1)" "unprognostic (7.66e-2)" "unprognostic (9.07e-2)" "unprognostic (1.66e-1)" "unprognostic (1.08e-1)" "unprognostic (2.76e-2)" 13.4 4.9 1.7 4.8 8.1 0.1 8.1 0.2 2.5 18.1 0.5 11.2 176.4 8.1 3.5 4.1 6.3 8.2 10.4 1.3 1.0 10.8 1.9 49.0 4.9 1.3 0.9 1.9 6.2 18.7 9.2 11.6 1.3 8.9 6.1 0.4 7.6 23.8 16.1 3.8 265.1 9.6 0.8 2.8 8.3 101.9 2.0 0.8 19.2 10.0 2.1 5.5 3.8 1.1 0.0 0.0 0.0 0.0 2.6 63.3 0.6 2.4 4.7 0.0 0.0 0.9 5.1 1.3 1.8 11.4 0.1 0.0 3.1 0.0 0.0 0.0 1.4 6.6 0.0 0.0 1.4 0.0 0.0 4.2 0.0 0.1 0.0 1.2 33.8 0.0 5.8 0.0 0.1 1.1 0.0 1.4 0.4 11.7 0.7 0.1 0.5 0.9 0.0 0.0 8.2 5.6 0.0 0.0 0.0 1.3 2.9 0.4 0.0 0.1 0.2 0.5 0.1 0.0 0.0 0.0 1.0 0.0 0.5 0.0 0.0 0.0 0.1 0.1 0.2 1.0 0.5 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 1.7 8.1 0.2 2.5 1.3 1.0 1.3 0.9 1.3 0.8 2.0 1.1 50.0 0.0 3.3 0.0 0.5 1.5 2.6 0.1 1.2 4.0 3.6 1.9 2.1 1.5 0.7 0.0 0.0 0.1 0.3 11.9 0.0 5.9 543.6 10.8 8.0 34.7 18.0 0.0 4.7 0.4 0.1 11.5 2.0 36.3 7.0 24.1 3.6 0.8 4.2 0.0 1.8 39.8 0.0 33.7 3.5 1322.9 4.4 13.6 3.6 4.7 0.0 1.8 0.0 1.0 0.2 0.7 40.9 2.6 0.1 4.2 1172.8 21.7 0.0 1.1 0.0 2.0 4.2 13.5 6.4 0.2 0.1 0.1 2.2 0.3 26.2 2.1 ACE2 ENSG00000130234 "Angiotensin I converting enzyme 2" Q9BYF1 X 15494566-15607236 "Enzymes, Metabolic proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters" "Host-virus interaction" "Carboxypeptidase, Host cell receptor for virus entry, Hydrolase, Metalloprotease, Protease, Receptor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 65.5;intestine: 242.2;kidney: 87.6" "Cell type enriched" "Detected in many" 5 "Proximal enterocytes: 294.8" "Group enriched" "Detected in many" 4 "colorectal cancer: 13.9;renal cancer: 26.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "NB-4: 1.2;NTERA-2: 1.2;SuSa: 1.9" "Low region specificity" "Detected in all" "Not detected" "Not detected" "HPA000288, CAB026174, CAB026213, CAB080024, CAB080025, CAB080027, CAB080028" Enhanced "Secreted to blood" NA NA 400000 "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 5: NTERA-2 - Transcription" "Cluster 45: Enterocytes - Digestion" "CAB026174: , CAB026213: , CAB080024: AB_10864415, CAB080025: AB_2809589, CAB080027: AB_2665870, CAB080028: AB_2665871, HPA000288: AB_1078160" "unprognostic (1.40e-1)" "unprognostic (7.26e-2)" "unprognostic (2.76e-2)" "unprognostic (5.71e-2)" "unprognostic (2.51e-1)" "unprognostic (5.26e-2)" "prognostic favorable (4.21e-4)" "unprognostic (2.34e-2)" "unprognostic (6.74e-3)" "unprognostic (2.54e-3)" "unprognostic (1.00e-1)" "unprognostic (1.74e-1)" "prognostic favorable (2.12e-5)" "unprognostic (1.94e-1)" "unprognostic (9.62e-2)" "unprognostic (2.11e-1)" "unprognostic (7.10e-2)" 8.9 0.5 0.1 1.4 0.1 0.6 4.3 0.4 0.3 0.6 1.9 9.9 183.3 0.5 0.5 1.8 1.5 65.5 42.7 0.2 0.2 87.6 5.7 0.8 0.4 0.2 0.2 1.8 2.5 1.5 0.1 1.2 0.2 0.4 5.9 0.3 1.4 4.1 0.7 0.3 242.2 0.5 0.1 0.1 2.6 49.7 0.2 0.5 4.5 0.5 0.2 0.8 1.2 0.2 0.0 0.0 0.3 0.0 0.2 0.0 0.8 0.1 0.0 0.2 0.2 0.2 0.3 0.4 0.3 0.0 0.3 0.7 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.1 0.0 0.1 0.0 0.2 0.0 0.5 1.2 1.2 0.0 0.0 0.3 0.2 0.5 0.2 0.4 0.2 0.9 0.0 0.4 0.0 1.9 0.4 0.4 0.1 0.0 0.0 0.3 0.4 0.1 0.5 0.5 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.2 0.1 0.1 0.4 0.3 0.2 0.2 0.2 0.2 0.2 0.1 0.2 0.2 0.4 0.0 0.5 1.3 1.4 0.1 0.5 5.0 0.0 0.0 1.6 0.0 11.2 55.8 2.6 0.0 0.0 4.2 0.1 22.9 3.9 1.2 0.5 1.1 0.3 1.0 7.2 0.0 0.8 0.8 0.3 4.6 0.0 0.6 0.0 3.9 0.0 0.9 0.8 0.0 0.8 8.2 0.0 0.0 0.0 1.4 8.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.9 5.1 6.0 0.0 1.0 294.8 48.8 2.0 0.0 19.7 0.0 8.9 1.1 1.0 0.0 0.1 12.7 0.3 0.1 10.6 2.2 ACY1 ENSG00000243989 "Aminoacylase 1" Q03154 3 51983340-51989197 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Hydrolase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 9 "intestine: 181.5;kidney: 449.9;liver: 274.9" "Cell type enhanced" "Detected in many" "Distal enterocytes: 31.6;Gastric mucus-secreting cells: 32.6;Proximal enterocytes: 144.8;Proximal tubular cells: 92.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Hep G2: 128.0" "CAB003695, HPA036174, HPA036175" Enhanced NA NA 23000000 "Cluster 27: Non-specific - Gene expression" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "CAB003695: AB_425286, HPA036174: AB_2674988, HPA036175: AB_2674989" "unprognostic (4.28e-2)" "unprognostic (1.89e-1)" "unprognostic (2.10e-1)" "unprognostic (2.48e-3)" "unprognostic (3.15e-1)" "unprognostic (6.51e-2)" "unprognostic (2.82e-2)" "unprognostic (1.47e-1)" "unprognostic (1.05e-2)" "unprognostic (6.08e-2)" "unprognostic (2.36e-2)" "unprognostic (2.70e-2)" "prognostic favorable (2.93e-4)" "unprognostic (3.57e-1)" "unprognostic (3.75e-1)" "unprognostic (7.88e-2)" "prognostic favorable (6.77e-4)" 19.2 24.0 5.6 7.3 5.7 8.8 20.7 6.4 7.3 13.9 11.6 30.6 181.5 4.3 21.8 10.7 13.0 10.7 14.5 5.1 6.0 449.9 274.9 9.2 7.2 6.5 5.9 4.8 8.7 28.2 4.7 9.7 6.6 14.3 30.5 1.9 16.4 11.1 20.2 8.2 138.2 6.9 6.7 8.1 23.6 3.2 6.1 5.1 21.0 34.6 9.2 12.5 7.1 6.6 15.9 26.2 13.2 34.1 28.9 39.4 40.5 12.6 28.2 29.4 14.9 41.2 67.9 7.2 12.2 22.0 13.2 20.0 14.7 81.2 11.5 21.8 10.7 25.3 13.9 128.0 49.7 19.8 21.0 48.0 67.2 25.4 69.1 25.8 11.5 14.6 47.1 23.9 29.9 35.2 0.6 38.9 23.4 92.1 39.3 8.0 14.1 63.5 74.5 50.8 16.9 18.2 12.6 62.6 29.5 7.5 42.3 27.9 7.1 22.0 21.9 24.8 18.8 61.7 16.9 12.1 28.1 42.9 29.0 9.1 15.7 0.4 10.7 15.1 5.7 7.4 2.6 4.5 21.2 6.1 4.1 4.7 0.0 20.4 6.4 2.8 3.8 9.7 5.6 5.7 6.4 7.3 5.1 6.0 6.5 5.9 6.6 6.7 6.1 6.6 0.5 3.2 3.2 0.0 4.9 0.6 1.0 1.9 17.1 0.2 2.7 1.3 0.2 1.5 2.5 5.5 0.0 3.9 0.3 31.6 9.8 16.6 0.2 0.2 0.9 0.9 2.4 15.8 0.0 8.3 4.5 4.3 32.6 0.6 7.0 0.2 1.1 13.1 1.9 0.0 0.0 11.2 4.1 1.9 0.3 0.8 0.6 4.2 0.0 0.0 9.3 0.8 1.0 0.0 0.0 16.4 23.3 0.0 14.9 0.6 144.8 92.0 1.7 1.1 0.0 0.6 2.0 0.1 0.2 18.5 0.4 4.1 2.6 1.0 14.5 0.4 AEBP1 ACLP ENSG00000106624 "AE binding protein 1" Q8IUX7 7 44104345-44114562 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Transcription, Transcription regulation" "Calmodulin-binding, DNA-binding, Repressor" "Disease variant, Ehlers-Danlos syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 103.0;Fibroblasts: 263.2;Leydig cells: 151.6;Peritubular cells: 508.9;Smooth muscle cells: 173.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 5 "plasmacytoid DC: 7.6" "Lineage enriched" "Detected in many" 5 "dendritic cells: 7.6" "Cell line enhanced" "Detected in many" "ASC diff: 141.1;BJ: 193.0;BJ hTERT+: 126.0;fHDF/TERT166: 208.9;JURKAT: 145.0;WM-115: 117.9" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "spinal cord: 57.6" "CAB009966, HPA047724, HPA063595, HPA064970" Supported Supported Nucleoplasm,Vesicles,Cytosol "Secreted - unknown location" NA NA 2700000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" Vesicles "Nucleoplasm, Cytosol" "CAB009966: AB_2225690, HPA047724: AB_2680132, HPA063595: AB_2685052, HPA064970: AB_2685394" "unprognostic (1.70e-2)" "unprognostic (5.42e-2)" "unprognostic (1.66e-2)" "unprognostic (1.45e-1)" "prognostic unfavorable (1.60e-4)" "unprognostic (1.13e-1)" "unprognostic (7.00e-2)" "unprognostic (8.79e-2)" "unprognostic (2.52e-1)" "unprognostic (3.27e-2)" "unprognostic (1.26e-1)" "unprognostic (1.94e-1)" "prognostic unfavorable (9.31e-9)" "unprognostic (2.88e-3)" "unprognostic (9.58e-2)" "unprognostic (1.17e-2)" "unprognostic (6.28e-3)" 190.5 59.9 45.0 59.8 56.0 10.6 153.0 38.6 44.8 312.1 28.0 95.3 19.2 268.8 59.6 65.7 199.8 155.9 156.7 47.3 92.9 68.7 20.3 166.0 45.5 114.7 81.5 253.7 28.9 10.1 43.3 89.0 79.6 112.1 25.0 1.3 50.7 213.5 21.3 84.8 79.1 119.3 74.3 54.4 71.2 40.4 52.1 73.3 83.7 14.1 16.7 138.7 198.0 66.6 0.6 0.0 44.5 0.1 141.1 49.6 1.0 193.0 126.0 21.6 4.5 0.0 0.1 5.3 20.9 208.9 0.2 0.1 2.4 3.5 9.1 0.6 0.0 13.3 0.1 0.0 39.6 0.1 0.3 75.8 0.0 72.9 0.1 1.1 9.7 145.0 8.3 0.3 0.0 0.2 86.9 16.1 19.1 0.0 0.4 71.3 1.7 1.7 5.0 0.0 4.9 25.3 0.1 0.3 85.9 41.9 0.4 14.4 34.1 0.0 86.2 0.5 0.3 1.0 0.9 102.8 0.4 0.2 117.9 0.0 0.0 0.0 0.3 0.0 0.2 1.5 0.2 0.0 0.0 1.4 0.9 0.5 0.0 0.1 0.0 7.6 0.0 0.3 45.0 56.0 38.6 44.8 47.3 92.9 114.7 81.5 79.6 74.3 52.1 66.6 23.6 0.0 2.5 32.3 11.8 34.5 5.7 1.3 1.8 0.8 2.0 14.6 26.4 1.5 1.4 7.3 0.0 2.0 22.7 0.0 0.0 0.9 3.1 3.3 103.0 18.0 0.0 1.3 0.1 0.0 3.3 263.2 8.6 2.9 2.5 33.3 30.4 0.6 3.6 0.0 0.3 0.0 0.0 1.8 42.0 18.0 151.6 3.2 85.4 17.8 1.0 0.2 1.0 6.0 0.3 0.4 0.0 508.9 9.7 16.9 0.0 2.2 2.2 0.8 39.5 23.6 173.4 4.0 4.6 1.5 27.4 3.4 4.8 28.7 0.0 2.4 AFG3L2 "SCA28, SPAX5" ENSG00000141385 "AFG3 like matrix AAA peptidase subunit 2" Q9Y4W6 18 12328944-12377227 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004479, HPA004480" Enhanced Supported Mitochondria NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 8: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" Mitochondria "HPA004479: AB_1078109, HPA004480: AB_1078108" "unprognostic (1.11e-1)" "unprognostic (7.49e-2)" "unprognostic (1.67e-1)" "prognostic unfavorable (8.68e-4)" "unprognostic (1.31e-1)" "unprognostic (5.06e-3)" "unprognostic (1.61e-1)" "unprognostic (2.33e-1)" "unprognostic (5.35e-2)" "unprognostic (1.54e-2)" "unprognostic (4.05e-2)" "unprognostic (3.00e-2)" "prognostic favorable (6.05e-14)" "unprognostic (5.90e-2)" "unprognostic (9.41e-2)" "unprognostic (5.74e-3)" "unprognostic (2.22e-1)" 26.1 25.9 16.4 21.9 17.0 32.4 29.2 18.2 19.0 24.1 30.8 60.8 79.9 22.1 17.5 41.5 23.8 18.3 88.0 17.0 18.7 62.7 51.0 21.8 23.7 17.7 16.6 24.1 41.1 76.0 18.6 23.5 18.8 24.6 54.1 20.3 30.8 24.4 145.4 29.8 58.7 25.4 15.8 18.5 39.1 18.5 19.0 24.3 39.2 155.8 31.0 30.9 19.6 17.6 56.5 56.6 39.7 44.8 45.2 48.6 52.7 61.9 61.1 86.6 63.1 88.1 34.1 161.3 66.3 56.6 76.8 55.6 101.4 71.3 70.3 38.1 43.5 48.5 59.3 83.5 61.1 185.0 69.8 54.3 76.3 82.1 107.7 47.8 64.0 57.0 111.3 92.8 43.6 89.0 66.7 58.5 55.3 277.4 41.9 74.0 125.1 135.2 74.9 123.6 73.7 51.3 97.0 103.8 90.0 50.5 47.8 84.5 49.0 102.4 88.6 98.7 81.7 64.7 80.7 104.1 56.2 71.4 48.0 3.8 16.5 12.4 11.6 17.6 13.9 14.0 13.8 17.9 21.8 10.3 17.2 20.2 1.1 28.4 16.2 11.5 9.5 13.4 16.4 17.0 18.2 19.0 17.0 18.7 17.7 16.6 18.8 15.8 19.0 17.6 24.3 41.7 49.2 23.2 36.6 22.2 45.3 21.5 42.7 50.2 36.5 36.2 74.9 50.1 28.1 35.0 50.1 58.5 29.1 85.2 72.4 39.5 5.5 37.8 52.3 27.7 39.1 61.0 21.1 37.4 37.9 31.2 53.5 46.1 14.5 41.3 21.8 85.6 37.0 30.3 26.8 82.6 18.3 32.6 14.4 5.5 32.9 34.2 23.2 12.2 27.6 26.9 40.2 14.1 17.7 47.8 43.1 30.1 38.8 43.1 88.7 100.0 22.1 58.3 26.3 53.6 26.9 50.9 65.0 75.8 31.3 92.8 28.4 60.8 94.9 38.2 AGBL1 "CCP4, FLJ32310" ENSG00000273540 "ATP/GTP binding protein like 1" Q96MI9 15 86079871-87049169 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Corneal dystrophy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 10 "skeletal muscle: 7.8;tongue: 23.2" "Cell type enhanced" "Detected in some" "Alveolar cells type 2: 16.7;Astrocytes: 28.7;Excitatory neurons: 15.6;Inhibitory neurons: 25.6;Oligodendrocyte precursor cells: 47.3" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 68: Oligodendrocytes - Mixed function" "unprognostic (3.70e-2)" "unprognostic (4.46e-2)" "unprognostic (1.06e-1)" 0.0 0.0 0.6 0.0 1.4 0.0 0.0 0.0 0.7 0.0 0.2 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 1.0 0.3 0.0 0.0 0.7 0.0 1.0 0.8 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.1 0.7 0.0 7.8 0.0 0.0 0.0 0.9 0.0 0.0 0.1 0.4 0.0 0.0 23.2 0.0 0.0 0.0 0.4 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 1.4 0.0 0.7 1.0 0.3 1.0 0.8 0.3 0.9 0.4 0.4 0.0 3.2 16.7 28.7 0.0 0.0 0.1 0.0 0.0 1.7 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.1 0.0 0.0 15.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 25.6 0.0 0.0 0.0 0.0 2.3 0.0 0.1 0.0 1.9 0.0 0.0 0.0 47.3 6.9 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 5.2 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.1 AGBL2 "CCP2, FLJ23598" ENSG00000165923 "ATP/GTP binding protein like 2" Q5U5Z8 11 47659591-47715389 "Enzymes, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "fallopian tube: 7.7;testis: 12.5" "Cell type enhanced" "Detected in many" "Early spermatids: 37.5;Endometrial ciliated cells: 25.7;Respiratory ciliated cells: 77.2;Spermatocytes: 19.3" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CAPAN-2: 2.3;T-47d: 1.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA007718 Uncertain NA NA "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 49: Ciliated cells - Cilium organization" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 49: Ciliated cells - Cilium organization" "HPA007718: AB_1078110" "unprognostic (3.44e-5)" "unprognostic (1.16e-1)" "unprognostic (5.84e-2)" "unprognostic (5.33e-4)" "unprognostic (1.13e-1)" "unprognostic (3.00e-1)" "unprognostic (2.05e-1)" "unprognostic (1.38e-2)" "unprognostic (9.83e-3)" "unprognostic (4.11e-2)" "unprognostic (5.56e-2)" "unprognostic (1.79e-1)" "unprognostic (8.24e-6)" "unprognostic (1.01e-2)" "unprognostic (1.28e-1)" "unprognostic (9.62e-2)" "unprognostic (1.17e-3)" 0.3 1.3 0.3 0.4 0.2 0.2 0.5 0.7 0.3 1.4 2.6 0.8 0.3 0.6 1.1 0.4 7.7 0.2 0.2 0.3 0.4 1.6 3.0 1.6 0.5 1.2 1.8 1.3 0.8 0.3 1.7 0.2 0.8 1.2 0.2 0.3 0.5 0.4 0.0 0.4 1.2 0.1 1.0 0.9 0.6 12.5 0.2 0.7 1.5 0.0 0.4 1.1 0.6 0.4 0.4 0.0 0.0 0.0 0.1 0.6 0.0 0.1 0.3 0.2 0.6 0.2 2.3 0.0 0.1 0.1 0.2 0.6 0.0 0.0 0.3 0.7 0.1 0.1 1.1 0.8 0.3 0.0 0.3 0.6 0.2 0.3 0.2 0.2 0.0 0.8 0.1 0.5 0.3 0.9 0.5 0.2 0.0 0.1 0.0 0.6 0.0 0.2 0.3 1.0 0.8 0.1 0.2 0.0 0.2 0.0 1.3 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.3 0.0 0.3 0.2 0.3 0.3 0.0 0.5 0.4 0.4 0.1 0.3 0.0 0.3 0.5 0.1 0.3 0.2 0.7 0.3 0.3 0.4 1.2 1.8 0.8 1.0 0.2 0.4 0.1 0.0 2.7 2.6 1.3 0.1 1.3 2.6 2.2 0.1 0.9 0.6 0.6 0.0 6.5 7.3 0.0 0.4 0.5 0.7 0.0 0.4 37.5 25.7 1.3 0.1 1.2 0.8 0.6 0.0 0.3 1.2 1.5 0.9 0.0 0.8 0.4 0.8 0.1 0.0 0.6 0.5 2.0 0.6 0.0 8.2 0.3 0.3 0.0 1.0 1.0 0.7 0.0 1.0 0.5 0.3 0.6 1.5 0.4 0.4 2.4 0.2 77.2 0.5 0.0 0.3 1.1 19.3 1.8 0.6 0.0 0.4 1.3 1.3 0.9 0.5 AGBL3 "CCP3, MGC32955" ENSG00000146856 "ATP/GTP binding protein like 3" Q8NEM8 7 134986508-135147963 "Enzymes, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in many" "epididymis: 7.9" "Cell type enhanced" "Detected in many" "Early spermatids: 70.5;Excitatory neurons: 40.7;Inhibitory neurons: 34.2;Oligodendrocytes: 37.3" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "HEK 293: 5.5" "Low region specificity" "Detected in all" "HPA020397, HPA024150" Uncertain Approved Cytosol NA No "Cluster 22: NK-cells - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 23: Spermatids - Flagellum & Golgi organization" Cytosol "HPA020397: AB_2242453, HPA024150: AB_1844639" "unprognostic (8.84e-2)" "unprognostic (1.49e-2)" "unprognostic (4.72e-2)" "unprognostic (2.18e-1)" "unprognostic (1.47e-1)" "unprognostic (3.39e-3)" "unprognostic (3.32e-3)" "unprognostic (4.18e-2)" "unprognostic (7.15e-4)" "unprognostic (5.00e-3)" "unprognostic (6.10e-4)" "unprognostic (3.16e-2)" "prognostic unfavorable (4.02e-4)" "unprognostic (2.18e-2)" "unprognostic (2.14e-1)" "unprognostic (8.13e-2)" "unprognostic (1.11e-3)" 1.0 0.9 1.0 2.3 1.3 2.2 2.3 2.0 3.0 0.8 1.2 1.2 0.8 2.9 7.9 0.1 1.8 0.7 0.8 1.0 1.9 1.7 0.6 1.8 2.3 1.3 1.2 3.5 2.3 0.4 0.3 0.9 1.1 1.9 1.5 1.3 2.5 2.1 2.4 2.5 2.0 1.6 1.3 3.8 2.5 5.1 1.7 0.9 2.8 0.8 0.9 0.3 0.2 1.8 1.7 0.9 2.2 0.5 0.6 0.8 1.3 0.4 0.0 0.3 0.5 3.0 1.9 2.7 0.8 0.0 0.9 1.8 0.8 0.3 0.0 2.2 5.5 2.3 4.0 3.0 0.0 1.0 0.0 0.1 0.0 1.3 0.0 0.0 0.9 3.0 1.7 1.5 0.3 1.5 0.6 0.9 1.9 0.2 0.2 1.6 0.1 0.8 1.5 0.3 1.3 1.4 0.3 0.0 0.2 0.0 1.2 2.3 0.0 0.2 0.5 0.3 1.0 3.3 1.1 1.3 1.1 2.8 2.7 0.0 0.1 0.1 0.8 0.0 0.7 0.8 0.4 0.9 0.2 0.7 0.7 1.7 0.2 0.9 0.0 0.6 0.6 0.6 1.0 1.3 2.0 3.0 1.0 1.9 1.3 1.2 1.1 1.3 1.7 1.8 6.7 3.2 0.6 18.3 3.5 1.3 0.9 1.2 2.8 5.1 2.2 2.2 2.1 4.3 2.0 9.2 2.1 0.3 0.9 0.6 7.9 4.6 70.5 6.6 1.8 4.8 3.0 3.0 40.7 2.9 0.4 2.8 4.6 2.6 1.3 3.2 5.0 1.9 0.5 3.3 34.2 0.4 0.0 1.3 0.7 11.8 3.4 0.8 5.4 22.5 6.9 2.8 1.0 16.6 37.3 1.7 0.1 2.2 6.1 1.3 0.4 7.6 6.4 3.3 0.0 2.0 4.1 21.4 6.3 1.2 0.3 0.1 2.0 2.4 0.5 1.0 AGBL4 "CCP6, FLJ14442" ENSG00000186094 "ATP/GTP binding protein like 4" Q5VU57 1 48532854-50023954 "Enzymes, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 5.4;retina: 5.9" "Group enriched" "Detected in some" 5 "Excitatory neurons: 1232.8;Inhibitory neurons: 630.3" "Not detected" "Not detected" "Region enhanced" "Detected in many" "cerebral cortex: 5.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "NTERA-2: 1.1;SCLC-21H: 1.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA037994 Approved NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 58: Brain - Synaptic function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA037994: AB_10673036" "unprognostic (3.06e-2)" "unprognostic (2.76e-1)" "unprognostic (2.58e-2)" "unprognostic (3.31e-4)" "unprognostic (3.42e-4)" "unprognostic (1.72e-1)" "unprognostic (3.86e-3)" "unprognostic (2.31e-2)" "unprognostic (1.50e-1)" "unprognostic (1.14e-1)" "unprognostic (5.85e-3)" "unprognostic (3.91e-2)" "unprognostic (1.51e-4)" "unprognostic (5.95e-2)" "unprognostic (1.11e-1)" "unprognostic (1.18e-2)" "unprognostic (2.85e-1)" 0.4 1.5 2.0 0.1 2.4 0.2 0.4 0.0 5.4 0.2 2.3 0.1 0.0 0.2 0.8 0.1 2.8 0.1 1.4 2.0 0.0 3.9 1.6 0.4 0.1 0.0 0.5 0.3 0.8 2.4 2.4 0.9 0.2 0.1 0.1 5.9 0.1 0.3 0.1 0.3 0.1 0.0 0.0 0.3 0.2 2.4 0.1 0.4 1.1 0.1 0.1 0.0 0.1 0.8 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 1.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 1.5 0.6 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.1 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 2.0 2.4 0.0 5.4 2.0 0.0 0.0 0.5 0.2 0.0 0.1 0.8 0.2 0.0 0.0 166.2 0.0 0.3 1.0 0.3 0.0 4.0 0.4 1.1 2.2 0.0 0.9 3.7 85.5 0.2 0.0 0.4 1.9 0.1 12.6 10.7 0.1 0.4 6.0 0.0 1232.8 0.2 0.1 0.5 0.0 0.2 0.0 0.2 0.4 0.1 0.1 5.0 630.3 0.5 2.0 0.0 0.0 9.1 0.3 0.0 0.0 40.3 0.0 2.4 0.0 142.2 19.2 0.0 0.1 0.7 0.0 0.3 0.0 4.4 10.5 22.6 0.0 0.7 0.3 19.9 10.4 0.0 0.0 0.1 0.0 0.4 0.1 0.2 AGBL5 "CCP5, FLJ21839" ENSG00000084693 "ATP/GTP binding protein like 5" Q8NDL9 2 27042364-27070622 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in all" 4 "parathyroid gland: 49.9;testis: 192.9" "Group enriched" "Detected in many" 6 "Early spermatids: 302.7;Late spermatids: 338.0;Spermatocytes: 156.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030981 Uncertain Supported "Microtubules,Cytokinetic bridge,Cytosol" Yes No "Cluster 34: Basophils - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" "Cytokinetic bridge" "Microtubules, Cytosol" "HPA030981: AB_10611673" "unprognostic (1.29e-2)" "unprognostic (8.70e-2)" "unprognostic (2.26e-1)" "unprognostic (3.13e-3)" "unprognostic (1.95e-1)" "unprognostic (1.07e-1)" "prognostic unfavorable (6.87e-5)" "unprognostic (1.86e-1)" "unprognostic (4.34e-1)" "unprognostic (6.20e-2)" "unprognostic (1.28e-1)" "unprognostic (1.20e-1)" "unprognostic (3.41e-2)" "unprognostic (5.56e-2)" "unprognostic (2.05e-1)" "unprognostic (1.69e-2)" "unprognostic (4.50e-2)" 8.8 16.7 8.4 8.0 7.4 13.6 12.4 7.8 8.2 14.4 9.5 16.2 8.8 14.0 26.0 18.3 20.8 14.3 12.7 7.3 11.3 22.5 7.2 11.2 10.7 8.3 7.8 14.4 15.0 49.9 12.5 11.2 8.9 15.2 11.5 16.3 21.2 16.5 7.1 20.5 9.9 14.6 6.1 8.5 11.8 192.9 9.1 15.6 28.5 6.5 8.6 14.9 7.3 7.5 55.0 34.7 55.4 37.2 11.6 23.0 62.9 10.9 23.5 30.9 31.9 30.2 40.5 30.3 34.0 18.9 43.4 24.6 44.8 49.4 33.9 25.9 66.8 44.5 42.0 65.7 23.6 21.6 14.4 24.4 36.7 27.1 22.0 46.9 32.8 43.5 38.9 23.8 30.3 21.5 63.2 32.3 39.4 39.4 23.7 64.5 62.9 48.0 31.9 13.6 37.1 53.6 21.5 16.7 35.0 53.9 24.9 16.3 16.4 28.6 39.2 13.8 23.9 47.7 27.2 62.4 31.8 24.4 26.1 8.8 1.8 4.5 3.3 1.1 2.5 4.6 4.1 4.6 4.1 2.3 3.6 2.2 1.1 8.5 0.7 2.3 2.8 3.8 8.4 7.4 7.8 8.2 7.3 11.3 8.3 7.8 8.9 6.1 9.1 7.5 3.6 0.0 10.1 5.2 6.3 3.3 8.3 7.2 13.6 5.7 8.6 6.7 6.7 10.0 6.8 9.2 0.0 14.7 1.8 5.9 19.6 8.3 302.7 13.0 3.9 4.9 2.4 11.6 7.9 6.0 7.9 6.4 5.6 5.8 1.3 14.1 6.4 4.1 5.2 0.0 9.1 8.4 6.1 3.1 3.5 338.0 10.5 8.0 7.2 6.5 4.9 6.8 0.0 10.1 10.1 5.0 7.6 11.3 17.1 6.0 6.3 25.0 10.7 10.0 0.0 4.2 7.0 156.8 41.2 16.3 2.7 8.3 5.0 9.4 8.6 10.5 AGTPBP1 "CCP1, KIAA1035, Nna1" ENSG00000135049 "ATP/GTP binding protein 1" Q9UPW5 9 85546539-85742029 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 60.1;brain: 73.4;retina: 46.5" "Cell type enhanced" "Detected in many" "Excitatory neurons: 176.7;Inhibitory neurons: 163.0;Oligodendrocytes: 463.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA057208, HPA071094" Approved Approved Nucleoli,Vesicles NA NA "Cluster 38: Basophils - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Nucleoli, Vesicles" "HPA057208: AB_2683370, HPA071094: " "unprognostic (2.15e-1)" "unprognostic (3.78e-2)" "unprognostic (4.93e-3)" "unprognostic (6.12e-2)" "unprognostic (1.42e-1)" "unprognostic (8.95e-3)" "unprognostic (1.86e-2)" "unprognostic (1.65e-1)" "unprognostic (1.71e-1)" "unprognostic (8.26e-3)" "unprognostic (5.69e-3)" "unprognostic (6.31e-2)" "unprognostic (3.07e-2)" "unprognostic (1.11e-1)" "unprognostic (1.39e-1)" "unprognostic (9.60e-3)" "unprognostic (1.25e-1)" 8.4 5.5 31.1 9.5 44.3 60.1 6.2 23.2 36.3 4.7 0.0 5.1 3.7 4.9 3.9 5.3 4.6 5.3 12.2 20.1 30.3 6.9 4.6 14.4 9.4 30.5 28.6 3.6 6.7 7.5 5.3 6.1 31.5 4.7 5.8 46.5 4.1 3.0 16.5 6.2 5.1 6.5 32.0 14.8 5.5 14.1 34.3 12.4 5.8 20.5 8.4 5.7 4.3 73.4 5.1 9.6 27.9 11.1 5.6 6.0 10.6 7.4 6.4 7.4 8.4 5.2 8.6 31.3 6.2 7.7 13.2 2.9 13.0 9.4 6.9 33.6 11.8 5.3 11.5 9.3 11.8 24.5 6.2 5.8 10.8 7.0 23.5 4.8 11.9 15.9 6.7 24.5 3.3 8.0 19.3 14.5 19.3 18.1 6.8 17.3 10.2 9.8 12.8 5.4 33.5 23.7 8.4 9.1 15.4 26.1 3.5 7.8 12.0 4.8 8.5 30.4 8.9 16.7 14.8 14.3 10.1 23.5 9.8 37.4 14.4 12.7 9.0 8.4 8.8 2.3 4.4 7.0 15.6 1.7 3.7 7.0 21.2 6.8 6.7 2.5 5.1 9.6 31.1 44.3 23.2 36.3 20.1 30.3 30.5 28.6 31.5 32.0 34.3 73.4 22.3 64.1 12.8 46.0 14.3 7.9 2.6 2.9 8.0 38.0 4.7 4.8 48.3 0.0 13.8 3.7 102.2 4.1 41.8 4.3 7.9 5.7 52.5 29.3 8.6 12.0 7.7 16.8 176.7 4.0 4.3 6.9 9.2 22.0 27.1 9.2 8.2 3.7 8.1 35.3 163.0 5.6 6.1 35.4 24.1 53.9 1.8 42.8 3.6 61.8 46.6 16.7 47.4 82.9 463.5 5.1 1.2 2.6 26.2 3.8 3.2 9.8 14.7 59.1 13.1 9.3 10.4 46.6 29.2 9.2 10.7 2.9 26.3 6.4 4.7 2.3 AMZ1 KIAA1950 ENSG00000174945 "Archaelysin family metallopeptidase 1" Q400G9 7 2679522-2775500 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 8 "brain: 7.5" "Cell type enriched" "Detected in some" 5 "Oligodendrocyte precursor cells: 104.5" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in single" "memory B-cell: 1.2" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "BEWO: 7.0;MCF7: 7.5;SK-BR-3: 5.2;T-47d: 27.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA020233 Uncertain NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 65: Brain - Ion transport" "Cluster 6: T47d - Mammary gland" "Cluster 68: Oligodendrocytes - Mixed function" "HPA020233: AB_1844818" "unprognostic (9.08e-3)" "unprognostic (1.66e-1)" "unprognostic (3.23e-3)" "unprognostic (1.81e-1)" "unprognostic (5.72e-2)" "unprognostic (7.79e-2)" "unprognostic (2.02e-2)" "unprognostic (3.42e-1)" "unprognostic (1.98e-1)" "unprognostic (7.16e-3)" "unprognostic (1.08e-1)" "unprognostic (1.21e-1)" "unprognostic (3.64e-9)" "unprognostic (1.60e-3)" "unprognostic (1.60e-1)" "unprognostic (1.44e-1)" "unprognostic (1.13e-1)" 0.0 0.0 7.4 0.2 7.5 0.4 0.1 3.4 5.1 0.9 0.0 0.1 0.1 0.8 0.0 0.0 0.3 0.1 0.1 3.6 1.9 0.0 0.8 0.5 0.2 3.6 3.7 0.2 0.1 0.0 0.6 0.8 2.1 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.7 0.6 0.4 0.0 0.6 6.1 0.0 0.0 0.0 0.3 0.1 0.3 1.7 0.0 0.0 0.0 0.0 0.0 0.0 7.0 2.3 3.4 1.6 2.2 0.0 1.0 0.6 0.2 2.2 0.2 0.0 0.0 0.0 1.6 0.4 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 1.5 0.0 7.5 0.0 0.7 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.1 5.2 0.0 0.1 27.7 0.0 0.0 0.1 0.1 0.1 0.1 1.0 0.2 0.0 0.6 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 7.4 7.5 3.4 5.1 3.6 1.9 3.6 3.7 2.1 0.6 6.1 1.7 0.1 0.0 0.5 14.4 0.9 0.0 0.1 0.0 0.0 0.8 0.3 0.3 3.3 0.0 0.0 0.0 4.2 0.3 1.6 0.0 0.0 0.0 18.8 0.5 1.6 0.4 0.0 0.0 6.1 0.0 9.8 0.3 0.0 0.3 0.0 0.0 0.0 0.0 1.8 0.0 10.6 0.2 0.0 0.0 1.9 9.9 0.0 1.7 1.8 5.6 0.0 0.0 0.0 104.5 20.7 0.4 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.7 0.0 0.2 0.4 0.0 0.3 0.0 0.1 0.1 0.8 0.0 0.0 0.1 AMZ2 ENSG00000196704 "Archaelysin family metallopeptidase 2" Q86W34 17 68205481-68257712 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 477.3;Early spermatids: 736.8;Late spermatids: 1665.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023299, HPA052406" Enhanced Supported "Nucleoplasm,Nuclear bodies,Cytosol" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 43: Testis - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "Nuclear bodies, Cytosol" "HPA023299: AB_2226909, HPA052406: AB_2681818" "unprognostic (3.04e-1)" "unprognostic (3.68e-2)" "unprognostic (3.93e-2)" "unprognostic (3.27e-3)" "unprognostic (3.32e-1)" "unprognostic (1.79e-2)" "prognostic unfavorable (1.32e-5)" "unprognostic (2.43e-1)" "unprognostic (3.92e-2)" "unprognostic (2.83e-3)" "unprognostic (3.59e-3)" "unprognostic (3.37e-1)" "prognostic unfavorable (3.14e-4)" "unprognostic (2.37e-1)" "unprognostic (2.95e-1)" "unprognostic (3.28e-1)" "unprognostic (7.62e-2)" 52.3 51.8 54.5 32.6 66.4 36.4 45.0 57.1 87.2 41.2 50.0 57.8 26.2 44.5 53.4 38.4 52.5 37.9 77.0 59.5 56.6 59.2 38.1 32.9 54.0 58.8 56.7 48.7 45.3 64.4 59.1 29.5 58.0 41.6 32.9 78.5 40.0 51.2 95.6 43.1 36.9 41.7 55.3 43.3 39.7 194.4 60.0 53.2 53.3 86.8 51.7 48.5 36.5 61.4 94.6 98.9 87.5 72.9 65.6 113.4 140.0 71.0 88.3 116.1 93.7 42.3 60.4 142.6 74.9 104.8 107.0 46.0 68.6 198.5 154.0 50.2 67.7 52.8 38.6 83.1 124.9 49.8 86.9 96.9 213.9 107.5 206.2 113.0 118.9 121.7 54.6 86.5 150.9 67.3 110.2 45.4 43.5 51.1 98.5 41.3 238.9 106.7 71.2 50.1 85.7 67.2 64.8 125.5 130.9 184.6 100.7 33.5 65.2 143.8 72.0 55.8 74.8 121.9 121.9 255.7 105.1 69.0 79.1 76.6 25.2 35.3 34.8 30.3 46.2 30.7 43.2 46.0 30.3 41.3 37.8 40.4 45.1 63.7 40.9 28.1 58.3 36.9 54.5 66.4 57.1 87.2 59.5 56.6 58.8 56.7 58.0 55.3 60.0 61.4 18.5 12.8 15.6 477.3 38.7 18.6 31.6 58.4 30.1 13.8 29.7 34.3 81.4 21.5 32.8 23.9 8.4 64.0 58.0 9.4 109.5 28.8 736.8 28.4 17.2 24.4 21.1 21.0 36.4 26.0 66.9 28.2 14.8 18.5 34.1 28.9 21.4 15.5 41.8 18.5 30.0 16.7 40.7 26.1 71.0 1665.0 36.1 39.0 56.9 27.2 46.4 65.7 69.0 56.8 47.7 25.4 10.8 32.7 46.2 17.7 15.2 69.0 61.8 12.8 19.7 26.5 26.8 274.4 59.4 26.4 22.6 34.2 49.3 26.1 15.1 24.5 ANPEP "CD13, gp150, LAP1, p150, PEPN" ENSG00000166825 "Alanyl aminopeptidase, membrane" P15144 15 89784895-89815401 "CD markers, Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Angiogenesis, Differentiation, Host-virus interaction" "Aminopeptidase, Developmental protein, Host cell receptor for virus entry, Hydrolase, Metalloprotease, Protease, Receptor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "intestine: 2384.1;pancreas: 675.0" "Cell type enriched" "Detected in many" 14 "Proximal enterocytes: 6315.2" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in all" 5 "cerebral cortex: 9.2;thalamus: 17.4" "Immune cell enriched" "Detected in many" 4 "neutrophil: 227.1" "Lineage enriched" "Detected in many" 4 "granulocytes: 227.1" "Cell line enhanced" "Detected in many" "ASC diff: 613.7;ASC TERT1: 764.2;BJ: 738.4;BJ hTERT+: 1135.6;fHDF/TERT166: 703.8;HMC-1: 660.3;HSkMC: 670.0;HUVEC TERT2: 874.8;TIME: 815.1;U-2197: 891.4" "Low region specificity" "Detected in all" "Region enriched" "Detected in many" 5 "spinal cord: 14.8" "CAB002417, HPA004625" Enhanced Supported "Plasma membrane" NA NA 1200000000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 56: Intestine - Transmembrane transport" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 45: Enterocytes - Digestion" "Plasma membrane" "CAB002417: AB_563491, HPA004625: AB_2667199" "unprognostic (6.31e-2)" "unprognostic (7.94e-3)" "unprognostic (6.91e-2)" "unprognostic (2.16e-1)" "unprognostic (2.50e-1)" "unprognostic (1.13e-1)" "unprognostic (2.23e-2)" "unprognostic (1.89e-1)" "unprognostic (2.50e-1)" "unprognostic (7.73e-2)" "unprognostic (5.28e-3)" "unprognostic (3.96e-1)" "unprognostic (4.04e-3)" "unprognostic (3.20e-2)" "unprognostic (2.01e-2)" "unprognostic (4.61e-3)" "unprognostic (1.99e-2)" 55.4 7.0 1.6 36.6 1.6 103.4 55.9 1.3 9.2 41.4 3.4 266.8 2384.1 3.6 1.7 4.8 8.0 120.3 6.9 1.3 1.5 249.7 271.8 34.3 12.8 1.5 2.1 1.9 675.0 0.8 1.9 33.1 2.5 94.0 59.9 0.0 42.1 5.5 2.5 32.5 1970.6 29.7 1.3 25.9 8.0 2.0 17.4 7.1 8.2 3.8 4.7 16.8 15.0 1.2 0.1 45.6 0.0 0.5 613.7 764.2 6.2 738.4 1135.6 95.3 81.6 5.8 0.4 0.2 8.4 703.8 0.0 0.6 5.6 0.2 38.6 0.1 0.1 137.3 4.6 122.8 352.0 11.4 660.3 670.0 1.4 302.3 0.3 4.4 874.8 0.0 3.8 0.8 37.8 0.1 0.6 355.4 1.9 0.0 49.9 0.3 0.1 9.5 449.2 0.0 1.2 7.2 0.1 1.3 0.1 1.8 0.5 72.1 815.1 385.3 0.6 891.4 0.1 0.4 0.1 0.1 0.9 0.9 20.5 22.2 56.3 41.1 0.1 27.4 0.0 0.2 0.0 0.0 26.2 0.2 0.0 0.0 227.1 0.0 49.7 0.7 0.0 25.7 1.6 1.6 1.3 9.2 1.3 1.5 1.5 2.1 2.5 1.3 17.4 1.2 2.4 0.0 3.0 0.0 5.2 9.9 2.8 1.4 0.6 0.0 35.7 12.8 1.2 391.7 19.7 20.2 0.0 13.0 0.7 429.8 43.0 15.4 0.2 0.5 10.1 8.4 3.0 6.6 0.3 386.2 16.3 31.0 0.0 0.4 24.1 0.3 79.2 192.4 37.5 0.0 0.3 199.6 2.0 54.1 63.2 0.2 2.8 71.9 3.6 0.0 38.3 0.0 0.0 0.0 0.1 75.5 316.9 1.5 2.1 20.9 6315.2 435.0 3.3 0.0 26.3 0.8 8.1 0.3 0.5 0.2 5.8 6.4 3.7 187.8 290.9 1.4 AOPEP "AP-O, APO, C90RF3, C9orf3, FLJ14675" ENSG00000148120 "Aminopeptidase O (putative)" Q8N6M6 9 94726604-95087159 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in some" 4 "Cardiomyocytes: 148.2;Cytotrophoblasts: 65.9;Extravillous trophoblasts: 43.7;Syncytiotrophoblasts: 88.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "HeLa: 30.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004633, HPA072729" Approved Approved "Cell Junctions" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 20: HeLa - Mitochondria" "Cluster 24: Non-specific - Transcription regulation" "Cell Junctions" "HPA004633: AB_1078362, HPA072729: AB_2686553" "unprognostic (4.25e-2)" "unprognostic (1.07e-3)" "unprognostic (6.29e-2)" "unprognostic (1.71e-1)" "unprognostic (1.12e-1)" "unprognostic (2.75e-2)" "unprognostic (9.59e-2)" "unprognostic (4.24e-2)" "unprognostic (2.99e-2)" "unprognostic (1.34e-1)" "unprognostic (2.60e-2)" "unprognostic (2.80e-1)" "prognostic favorable (6.33e-5)" "unprognostic (2.31e-1)" "unprognostic (2.56e-1)" "unprognostic (3.29e-2)" "unprognostic (3.37e-2)" 5.6 6.6 11.8 4.9 20.4 2.2 7.0 16.9 16.3 8.1 23.8 6.9 4.3 18.5 8.3 16.9 10.3 12.1 29.4 15.9 15.5 7.2 7.6 10.4 2.2 23.0 15.7 8.1 11.2 16.3 5.7 24.3 20.7 14.3 5.8 4.7 12.2 15.2 30.5 38.6 5.0 15.8 11.1 5.0 5.7 6.0 15.4 2.6 11.2 15.3 5.6 7.7 6.8 40.5 6.8 27.6 3.3 5.3 3.4 3.8 12.4 6.4 3.0 6.3 4.1 6.3 8.7 2.1 5.3 9.8 8.7 24.8 5.7 6.1 3.4 13.2 4.9 2.0 30.1 5.8 6.1 1.8 1.4 4.4 23.7 5.5 4.1 17.7 3.5 3.3 3.4 3.0 11.4 10.1 2.8 2.3 4.4 7.8 10.7 4.2 9.4 2.7 11.0 6.4 6.6 9.7 11.2 9.4 2.5 8.5 10.8 1.5 2.7 2.9 2.8 10.8 3.4 2.5 3.6 1.0 9.8 1.7 4.8 0.0 1.4 0.9 1.4 1.0 0.8 0.9 1.1 1.2 2.2 2.2 0.8 1.0 0.5 1.4 0.7 2.1 0.8 0.7 11.8 20.4 16.9 16.3 15.9 15.5 23.0 15.7 20.7 11.1 15.4 40.5 20.2 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 148.2 0.0 0.0 0.0 0.0 65.9 1.7 0.0 0.0 0.0 0.0 0.0 0.0 7.4 0.0 0.0 0.0 0.0 43.7 13.8 0.0 0.0 0.0 0.0 0.0 0.0 9.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.1 0.0 0.0 0.0 0.0 88.2 0.2 0.0 0.0 0.0 ATP23 "KUB3, XRCC6BP1" ENSG00000166896 "ATP23 metallopeptidase and ATP synthase assembly factor homolog" Q9Y6H3 12 57906039-57959148 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 27.8" "Cell type enhanced" "Detected in many" "Breast myoepithelial cells: 12.7;Cytotrophoblasts: 14.4;Distal tubular cells: 17.6;Extravillous trophoblasts: 15.2;Proximal tubular cells: 26.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in single" "Immune cell enriched" "Detected in single" 4 "neutrophil: 1.6" "Lineage enriched" "Detected in single" 4 "granulocytes: 1.6" "Cell line enhanced" "Detected in some" "A549: 1.0;Karpas-707: 2.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035804, HPA043204" Uncertain Enhanced "Vesicles,Plasma membrane,Cell Junctions,Cytosol" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 71: Testis - DNA repair" "Cluster 2: Karpas-707 - Immune response" "Cluster 7: Non-specific - Mitochondria" "Vesicles, Plasma membrane" "Cell Junctions, Cytosol" "HPA035804: AB_10601026, HPA043204: AB_2678361" "unprognostic (2.56e-1)" "unprognostic (1.31e-2)" "unprognostic (8.82e-2)" "unprognostic (2.92e-2)" "unprognostic (2.30e-2)" "unprognostic (6.16e-2)" "unprognostic (1.20e-1)" "unprognostic (5.28e-2)" "unprognostic (5.41e-3)" "unprognostic (1.03e-2)" "unprognostic (1.24e-1)" "unprognostic (1.06e-1)" "prognostic unfavorable (1.44e-5)" "unprognostic (4.36e-2)" "unprognostic (1.12e-1)" "unprognostic (1.80e-1)" "unprognostic (2.27e-1)" 7.5 4.9 0.6 0.4 0.5 0.1 5.6 0.6 0.9 4.1 0.5 8.1 0.2 3.1 0.0 5.6 3.2 0.0 4.6 1.0 0.3 4.0 5.2 2.6 0.1 0.4 0.2 3.1 5.9 0.0 2.8 0.1 0.4 3.3 0.0 0.5 3.6 0.0 12.4 4.4 4.3 0.0 0.3 3.2 4.2 27.8 0.5 0.0 3.5 0.0 0.1 4.7 4.0 0.3 0.6 1.0 0.0 0.3 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.5 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.2 0.0 0.9 0.2 0.0 0.0 0.4 0.1 0.0 0.3 0.0 0.1 0.0 0.0 0.6 2.6 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.3 0.6 0.8 0.1 0.0 0.4 0.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.4 0.3 0.0 0.4 0.0 0.0 0.4 0.0 0.6 0.1 0.2 0.0 0.2 0.2 0.2 0.2 0.1 0.3 0.0 0.3 0.2 0.2 1.6 0.1 0.1 0.1 0.1 0.0 0.6 0.5 0.6 0.9 1.0 0.3 0.4 0.2 0.4 0.3 0.5 0.3 8.0 0.0 9.2 0.0 2.3 0.0 0.0 0.0 0.0 0.0 7.4 12.7 0.0 0.0 1.8 3.7 0.0 14.4 4.2 0.0 17.6 6.1 0.0 5.6 4.9 2.8 0.0 0.0 0.0 10.7 15.2 2.3 0.0 6.0 11.4 6.8 0.0 0.0 10.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.2 0.0 0.0 1.0 0.0 0.0 0.0 0.0 3.7 0.0 0.0 0.9 0.0 0.0 26.1 0.7 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 3.4 3.0 9.5 0.0 0.0 BRCC3 "BRCC36, C6.1A, CXorf53" ENSG00000185515 "BRCA1/BRCA2-containing complex subunit 3" P46736 X 155071420-155123077 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Ubl conjugation pathway" "Chromatin regulator, Hydrolase, Metalloprotease, Protease" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA048737 Supported Nucleoplasm NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA048737: AB_2680504" "unprognostic (1.16e-2)" "unprognostic (2.40e-2)" "unprognostic (5.99e-2)" "unprognostic (1.53e-1)" "unprognostic (1.43e-1)" "unprognostic (2.88e-2)" "unprognostic (4.48e-2)" "unprognostic (6.47e-3)" "unprognostic (1.33e-1)" "unprognostic (9.68e-2)" "unprognostic (1.35e-3)" "unprognostic (3.72e-2)" "unprognostic (3.71e-3)" "unprognostic (7.14e-3)" "unprognostic (1.57e-1)" "unprognostic (1.17e-1)" "unprognostic (1.90e-1)" 9.9 12.9 6.8 12.1 6.6 15.6 15.8 9.2 7.7 12.8 6.8 22.3 19.3 9.2 18.5 18.4 11.6 8.4 11.2 6.6 7.0 17.8 13.8 9.8 15.4 5.9 7.1 8.1 11.4 14.7 5.2 14.0 6.7 14.6 23.3 12.9 18.5 10.9 17.8 11.1 16.9 10.6 5.4 11.0 15.6 2.3 7.4 13.4 15.2 17.6 15.5 12.6 6.3 6.6 95.6 45.1 24.4 19.6 20.9 17.7 37.9 35.9 25.8 24.1 52.3 44.0 40.1 84.1 62.8 22.1 36.1 36.3 54.4 33.6 38.0 45.4 42.1 17.7 76.1 41.4 15.8 62.8 25.5 17.3 16.9 35.1 28.5 23.1 30.1 32.2 27.4 24.9 24.6 33.6 25.8 28.8 22.3 101.9 41.9 36.2 43.3 42.0 36.8 36.5 38.0 17.3 25.6 43.6 27.3 31.5 25.2 33.7 31.5 20.4 32.1 27.6 53.8 30.0 56.1 114.5 28.2 61.5 25.3 36.8 18.8 34.0 20.0 22.9 23.4 17.6 19.3 18.2 21.2 16.7 14.8 16.6 10.5 28.4 24.1 13.3 25.4 16.9 6.8 6.6 9.2 7.7 6.6 7.0 5.9 7.1 6.7 5.4 7.4 6.6 12.0 32.1 23.3 16.6 14.0 5.5 7.0 13.8 6.8 13.0 15.0 14.0 27.2 10.0 28.5 7.3 14.6 26.7 17.6 25.5 19.6 22.9 0.6 13.8 13.7 10.6 9.6 17.1 31.9 19.8 26.6 11.3 12.8 15.9 26.6 13.7 8.6 8.6 17.4 8.4 35.2 22.6 16.2 9.5 7.0 1.3 5.9 14.5 5.4 15.9 22.3 12.9 20.6 26.7 29.2 14.7 16.8 12.0 21.1 10.3 16.3 18.0 25.1 14.5 19.7 12.6 22.9 1.2 1.3 26.2 6.5 13.5 14.9 18.3 27.3 8.3 CNDP1 "CN1, CPGL2, HsT2308, MGC10825" ENSG00000150656 "Carnosine dipeptidase 1" Q96KN2 18 74534500-74587212 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "brain: 85.6" "Cell type enriched" "Detected in some" 10 "Oligodendrocytes: 361.7" "Cancer enhanced" "Detected in some" "glioma: 4.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 38 "U-266/84: 15.4" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA008933, HPA073283" Enhanced "Secreted to blood" NA NA 2100000000 "Cluster 70: Brain - Nervous system development" "Cluster 16: U-266 - Nucleosome" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA008933: AB_1847033, HPA073283: " "unprognostic (7.43e-3)" "unprognostic (6.00e-2)" "unprognostic (8.55e-3)" "unprognostic (3.93e-1)" "unprognostic (1.32e-1)" "unprognostic (2.17e-2)" "unprognostic (8.04e-3)" "unprognostic (1.12e-2)" "unprognostic (2.81e-1)" "unprognostic (1.16e-1)" "unprognostic (1.16e-1)" "unprognostic (1.66e-1)" "unprognostic (6.90e-3)" "unprognostic (1.14e-1)" "unprognostic (3.30e-2)" "unprognostic (1.33e-1)" "unprognostic (1.28e-1)" 0.0 0.0 27.4 0.0 74.2 0.1 0.0 80.4 39.0 0.0 6.0 0.0 1.3 0.0 0.7 0.0 0.0 0.1 0.0 30.5 51.3 0.5 12.9 0.0 0.0 85.6 76.9 0.0 0.0 0.0 0.2 0.0 74.3 0.1 0.0 0.1 0.0 0.1 1.4 0.1 0.2 0.0 39.7 0.0 0.0 0.3 74.9 0.0 0.2 0.0 0.0 0.0 0.0 80.7 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 15.4 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 27.4 74.2 80.4 39.0 30.5 51.3 85.6 76.9 74.3 39.7 74.9 80.7 0.2 0.0 0.0 0.3 0.2 0.1 0.4 0.2 0.0 0.6 0.5 0.3 0.7 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.1 8.6 0.5 0.2 0.2 0.0 2.7 1.2 0.2 0.0 0.3 0.0 1.5 0.0 0.2 0.7 35.1 0.1 0.0 1.5 0.7 0.0 1.2 1.1 3.1 0.0 0.2 0.0 1.0 0.0 0.5 0.0 3.0 361.7 0.2 0.1 0.0 0.0 0.4 0.4 24.5 0.0 1.0 0.0 0.6 0.2 1.0 0.4 0.0 0.3 0.0 0.4 0.0 0.5 0.2 CNDP2 "CN2, CPGL, FLJ10830, HsT2298, PEPA" ENSG00000133313 "Carnosine dipeptidase 2" Q96KP4 18 74495816-74523454 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Glandular and luminal cells: 334.7;Proximal enterocytes: 629.1;Proximal tubular cells: 487.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Karpas-707: 458.7;RPMI-8226: 616.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB026196, HPA036898, HPA036899" Enhanced Enhanced Nucleoplasm,Cytosol NA NA 2600000 "Cluster 27: Non-specific - Gene expression" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 2: Karpas-707 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nucleoplasm, Cytosol" "CAB026196: , HPA036898: AB_2675370, HPA036899: AB_2675371" "unprognostic (2.81e-2)" "unprognostic (9.96e-2)" "unprognostic (3.28e-1)" "unprognostic (1.19e-3)" "unprognostic (2.57e-2)" "unprognostic (5.06e-2)" "unprognostic (2.84e-2)" "unprognostic (5.35e-2)" "unprognostic (1.49e-1)" "unprognostic (9.31e-2)" "unprognostic (1.56e-3)" "unprognostic (1.15e-1)" "prognostic favorable (3.50e-6)" "unprognostic (2.37e-3)" "unprognostic (4.65e-3)" "unprognostic (1.51e-1)" "unprognostic (1.34e-1)" 54.8 40.7 125.3 75.0 147.0 25.1 60.4 139.4 156.9 136.8 113.0 83.6 190.1 44.2 122.8 78.4 140.8 94.4 63.7 123.7 133.2 327.3 261.1 82.3 86.3 143.1 137.4 34.4 100.7 58.5 48.0 75.4 144.7 122.5 79.5 42.1 57.4 101.7 26.6 47.0 255.0 37.9 140.4 137.0 103.5 20.9 143.9 52.5 159.1 22.4 82.2 94.5 47.4 157.6 64.6 85.0 60.5 57.4 72.2 42.5 252.3 66.0 61.7 88.3 87.4 49.6 67.1 80.3 81.4 72.1 69.0 95.0 92.7 124.9 62.7 121.3 36.7 80.2 42.1 79.6 104.6 158.7 119.3 64.5 93.9 76.4 136.6 50.1 78.3 94.6 86.3 458.7 59.1 71.6 84.9 75.6 91.0 42.4 50.3 91.3 69.4 616.6 346.1 264.1 65.3 34.2 51.6 360.2 91.6 143.0 151.5 64.0 82.5 93.9 79.5 21.2 45.2 85.5 380.6 108.1 63.6 113.8 80.2 37.1 115.4 49.0 77.6 166.3 84.4 102.4 61.6 72.2 185.1 110.5 65.5 72.4 15.9 124.6 174.1 161.3 94.5 135.7 125.3 147.0 139.4 156.9 123.7 133.2 143.1 137.4 144.7 140.4 143.9 157.6 39.2 73.7 62.7 16.6 55.7 9.2 40.3 48.6 12.5 33.6 76.5 36.4 26.9 77.2 56.8 119.5 16.7 157.9 47.8 99.0 187.9 168.1 3.3 187.7 49.7 49.6 65.3 23.3 8.8 154.7 130.9 23.5 63.7 334.7 12.0 34.0 40.0 119.8 216.3 43.7 10.8 82.9 75.3 122.9 24.9 4.1 18.6 79.0 17.8 13.1 90.8 86.6 55.6 15.6 51.7 108.9 103.5 16.6 44.4 65.2 629.1 487.6 73.3 31.6 13.1 15.2 22.3 8.3 7.2 27.1 9.7 109.0 38.2 32.8 99.8 53.8 COPS5 "CSN5, JAB1, MOV-34, SGN5" ENSG00000121022 "COP9 signalosome subunit 5" Q92905 8 67043079-67083783 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 347.5;Late spermatids: 427.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004242, HPA004845, HPA051531" Supported Enhanced Nucleoplasm NA NA 37000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "CAB004242: AB_627835, HPA004845: AB_1078557, HPA051531: AB_2681522" "unprognostic (1.90e-3)" "unprognostic (1.35e-1)" "unprognostic (1.61e-1)" "unprognostic (2.85e-3)" "unprognostic (2.53e-1)" "unprognostic (4.16e-2)" "unprognostic (2.04e-3)" "unprognostic (1.39e-1)" "unprognostic (2.15e-2)" "unprognostic (4.48e-2)" "unprognostic (4.74e-3)" "unprognostic (1.96e-2)" "unprognostic (1.90e-3)" "unprognostic (2.88e-2)" "unprognostic (1.76e-1)" "unprognostic (2.58e-1)" "unprognostic (1.18e-2)" 43.5 43.8 52.1 33.3 54.2 39.4 45.2 58.3 62.6 34.2 52.0 45.5 45.6 34.0 43.6 42.2 35.6 31.6 100.0 53.2 57.1 56.3 71.0 33.1 40.9 55.1 53.3 33.4 43.0 58.5 31.1 50.9 56.8 36.4 51.6 39.7 42.3 36.6 125.2 36.0 47.8 47.6 57.4 33.4 37.6 58.7 56.2 52.6 37.8 134.9 48.7 42.2 30.0 59.7 104.0 97.8 79.6 74.4 83.1 88.3 63.3 89.0 74.0 121.2 108.9 62.6 125.4 96.5 39.9 93.6 86.8 84.1 109.2 98.9 134.0 92.4 92.1 135.9 95.2 87.3 82.2 86.3 79.1 81.0 126.2 99.1 132.6 95.2 121.2 100.3 163.0 64.6 111.8 96.5 154.3 157.6 107.1 217.2 108.6 97.2 56.7 76.4 131.3 91.6 48.6 66.7 51.0 98.4 91.6 71.2 160.9 90.8 89.9 60.1 74.9 74.7 70.3 81.4 108.5 127.7 89.1 97.6 84.1 65.8 52.0 64.5 35.8 55.7 37.2 36.8 34.6 39.9 63.9 33.7 36.1 32.4 38.3 51.9 56.6 34.0 53.2 43.8 52.1 54.2 58.3 62.6 53.2 57.1 55.1 53.3 56.8 57.4 56.2 59.7 55.0 22.4 26.0 19.2 40.6 49.3 45.1 102.6 28.5 36.4 43.7 51.8 119.9 58.6 61.2 31.3 33.3 143.8 58.0 38.1 88.0 73.4 347.5 44.6 38.2 46.4 34.2 69.2 21.5 60.0 101.4 45.2 25.5 37.1 36.1 50.9 34.2 35.5 79.3 25.2 21.5 41.5 59.0 31.7 28.5 427.2 43.2 40.2 28.4 10.3 59.9 62.0 56.7 18.6 32.4 50.1 48.6 51.1 46.6 54.0 87.8 81.9 46.1 53.0 32.9 49.1 87.8 123.4 49.6 42.9 47.5 127.8 42.3 72.5 55.4 50.6 COPS6 "CSN6, MOV34-34KD" ENSG00000168090 "COP9 signalosome subunit 6" Q7L5N1 7 100088969-100092187 "Enzymes, Predicted intracellular proteins" "Host-virus interaction" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044315 Approved Supported Nucleoplasm "Intracellular and membrane" NA NA 110000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 80: Striated muscle - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA044315: AB_10959750" "unprognostic (1.48e-2)" "unprognostic (2.43e-2)" "unprognostic (6.56e-3)" "unprognostic (1.38e-1)" "unprognostic (5.84e-2)" "unprognostic (2.09e-2)" "unprognostic (3.62e-3)" "unprognostic (2.93e-2)" "unprognostic (2.00e-1)" "unprognostic (2.45e-2)" "unprognostic (4.96e-2)" "unprognostic (1.25e-1)" "prognostic unfavorable (6.72e-4)" "unprognostic (1.20e-1)" "unprognostic (3.58e-2)" "unprognostic (8.57e-2)" "unprognostic (8.77e-2)" 71.3 85.5 98.5 48.7 103.0 51.8 68.6 102.5 102.0 87.1 99.5 101.3 44.1 86.5 84.0 90.6 78.1 52.9 112.9 101.9 100.7 70.8 71.6 56.5 50.3 99.3 98.4 74.8 60.2 100.8 79.2 64.0 100.4 68.8 57.8 61.4 65.0 74.2 147.3 61.8 58.4 78.5 101.7 63.1 78.4 57.4 98.7 63.1 61.5 152.8 60.6 90.5 74.7 105.0 167.6 233.4 136.2 163.5 116.1 138.4 86.6 147.7 223.5 239.7 174.9 191.9 153.8 114.4 186.1 242.2 267.3 124.1 155.1 247.9 240.4 114.9 242.6 98.2 215.9 149.3 243.3 112.1 97.6 137.5 161.4 259.2 273.9 159.5 333.0 172.7 142.7 160.5 286.4 413.7 251.6 164.8 124.0 241.3 273.2 117.6 226.6 275.4 193.6 153.8 213.4 158.6 152.7 298.5 114.1 176.4 123.7 109.2 177.9 231.3 211.1 280.5 264.8 118.1 140.2 235.3 175.5 150.0 350.6 231.8 187.8 168.2 178.8 206.6 180.7 168.0 176.8 170.9 211.3 170.3 137.4 153.6 73.5 163.5 194.6 157.8 225.8 146.6 98.5 103.0 102.5 102.0 101.9 100.7 99.3 98.4 100.4 101.7 98.7 105.0 87.8 51.3 44.2 24.8 73.4 110.6 118.1 208.1 70.0 108.3 62.8 76.3 166.3 88.6 117.2 86.5 52.1 197.3 84.2 55.1 211.3 138.3 76.5 61.6 103.4 94.9 75.3 69.0 20.9 113.5 133.7 116.0 52.5 48.3 90.7 100.5 90.3 63.2 128.8 95.9 21.0 67.4 158.7 69.6 82.5 197.1 127.7 55.1 156.5 13.1 101.4 147.0 115.4 17.6 24.0 115.1 64.7 125.3 84.3 95.0 84.2 214.2 117.9 127.1 98.6 76.3 261.5 80.5 100.2 81.2 100.3 137.9 82.7 137.9 87.1 96.1 CPA1 CPA ENSG00000091704 "Carboxypeptidase A1" P15085 7 130380339-130388114 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 2326 "pancreas: 237498.3" "Cell type enriched" "Detected in some" 19 "Exocrine glandular cells: 10133.0" "Cancer enriched" "Detected in some" 639 "pancreatic cancer: 1377.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "AN3-CA: 11.8" "Not detected" "Not detected" "Low region specificity" "Detected in some" "HPA021836, CAB025197, HPA052215" Enhanced "Secreted to digestive system" NA NA 110000000 "Cluster 25: Pancreas - Digestion" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 1: Pancreatic cells - Digestion" "CAB025197: , HPA021836: AB_1846005, HPA052215: AB_2681764" "unprognostic (8.41e-2)" "unprognostic (9.24e-4)" "unprognostic (5.22e-2)" "unprognostic (1.76e-1)" "unprognostic (3.97e-1)" "unprognostic (1.76e-1)" "unprognostic (2.27e-1)" "unprognostic (1.15e-2)" "unprognostic (1.35e-1)" "unprognostic (1.34e-6)" "unprognostic (4.99e-1)" "unprognostic (1.67e-1)" "unprognostic (2.16e-1)" "unprognostic (4.37e-2)" 27.9 4.8 0.2 5.6 0.2 4.7 13.6 0.1 0.2 11.9 1.2 4.5 33.6 5.0 0.1 6.9 3.7 0.2 43.5 0.2 0.3 4.6 12.9 3.3 8.7 0.1 0.1 102.1 237498.3 0.0 5.0 18.4 0.1 6.9 0.0 0.2 39.5 0.1 4.7 6.6 20.8 0.4 0.2 7.7 21.3 5.4 0.2 0.1 3.0 0.4 0.0 2.8 4.0 0.4 0.0 0.0 0.0 11.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.4 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 2.1 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 1.7 0.0 0.2 0.0 1.5 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.1 0.2 0.2 0.3 0.1 0.1 0.1 0.2 0.2 0.4 0.1 3.2 0.0 0.3 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.9 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.0 5.9 12.0 1.9 0.0 0.1 0.1 0.0 0.0 0.0 10133.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 7.6 0.9 1.2 0.0 1.0 44.5 2.1 0.0 0.0 0.0 527.2 0.0 0.7 0.0 0.4 0.0 0.0 0.0 0.1 0.0 16.2 2.7 0.9 5.5 0.0 0.0 1.6 0.0 2.5 0.0 0.1 CPA2 ENSG00000158516 "Carboxypeptidase A2" P48052 7 130266863-130289798 "Enzymes, Metabolic proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 416 "pancreas: 45360.2" "Cell type enriched" "Detected in some" 10 "Exocrine glandular cells: 4973.8" "Cancer enriched" "Detected in many" 60 "pancreatic cancer: 411.4" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AN3-CA: 2.2;CACO-2: 3.8;RH-30: 3.0;SCLC-21H: 1.6" "Low region specificity" "Detected in all" "Not detected" "Not detected" "HPA020342, HPA021317" Enhanced Approved "Golgi apparatus" "Secreted to digestive system" NA NA 1500000 "Cluster 25: Pancreas - Digestion" "Cluster 39: CACO-2 - Unknown function" "Cluster 1: Pancreatic cells - Digestion" "Golgi apparatus" "HPA020342: AB_1846007, HPA021317: AB_1846008" "unprognostic (1.12e-1)" "unprognostic (3.97e-1)" "unprognostic (4.21e-2)" "unprognostic (1.82e-2)" "unprognostic (1.38e-1)" "unprognostic (6.76e-2)" "unprognostic (4.65e-2)" "unprognostic (1.08e-1)" "unprognostic (1.40e-1)" "unprognostic (1.84e-1)" "unprognostic (2.66e-1)" "unprognostic (3.84e-5)" "unprognostic (7.52e-2)" "unprognostic (1.42e-1)" "unprognostic (7.12e-2)" "unprognostic (8.48e-2)" 5.5 1.0 0.3 0.7 0.8 0.4 2.6 1.0 0.9 1.9 0.2 1.3 17.4 0.8 0.1 1.5 0.7 0.0 8.4 0.3 0.6 0.9 2.6 0.7 1.4 2.8 1.3 19.7 45360.2 0.0 1.4 3.2 2.5 1.5 0.4 0.8 7.8 0.0 0.8 1.1 30.6 0.0 1.2 1.2 108.9 2.2 1.1 0.1 0.6 0.0 0.0 0.5 0.8 3.1 0.0 0.0 0.4 2.2 0.0 0.0 0.0 0.0 0.0 0.3 0.0 3.8 0.0 0.0 0.5 0.0 0.3 0.0 0.7 0.0 0.0 0.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.2 0.0 3.0 0.0 0.0 0.3 1.6 0.0 0.1 0.0 1.0 0.1 0.0 0.1 0.0 0.0 0.6 0.4 0.3 0.0 0.4 0.1 0.4 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.8 1.0 0.9 0.3 0.6 2.8 1.3 2.5 1.2 1.1 3.1 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.3 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.6 1.9 8.1 4.3 0.0 0.0 0.9 0.0 0.0 0.1 4973.8 0.0 0.2 4.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.5 0.0 0.0 0.0 10.5 0.3 0.5 0.0 0.0 13.9 4.6 0.0 0.5 1.0 471.3 52.9 0.0 0.0 0.0 9.9 0.0 0.0 0.3 0.0 0.0 1.3 0.4 2.0 0.0 0.1 0.3 0.0 0.2 1.5 0.2 CPA3 ENSG00000163751 "Carboxypeptidase A3" P15088 3 148865296-148897203 "Enzymes, Metabolic proteins, Plasma proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 112.0;lung: 86.3" "Cell type enriched" "Detected in some" 26 "granulocytes: 4422.8" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 1534 "basophil: 1115.4" "Lineage enriched" "Detected in single" 5518 "granulocytes: 1115.4" "Cell line enriched" "Detected in some" 45 "HEL: 303.3" "Not detected" "Not detected" "HPA006479, HPA008689, CAB020712" Enhanced Approved "Nucleoplasm,Golgi apparatus" "Secreted to blood" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 36: HEL - Hemostasis" "Cluster 60: Granulocytes - Receptor signaling" "Golgi apparatus" Nucleoplasm "CAB020712: , HPA006479: AB_1078396, HPA008689: AB_1846009" "unprognostic (1.07e-1)" "unprognostic (3.03e-2)" "unprognostic (2.66e-3)" "unprognostic (9.13e-3)" "unprognostic (3.50e-1)" "unprognostic (1.18e-3)" "unprognostic (2.47e-1)" "unprognostic (1.57e-2)" "unprognostic (2.14e-1)" "unprognostic (9.51e-2)" "unprognostic (1.89e-1)" "unprognostic (5.30e-3)" "unprognostic (3.50e-3)" "unprognostic (5.18e-3)" "unprognostic (3.24e-2)" "unprognostic (1.74e-1)" "unprognostic (1.69e-3)" 18.2 2.6 0.0 19.9 0.4 25.7 20.9 0.0 0.0 59.4 0.3 39.2 27.3 26.1 19.3 41.1 6.6 112.0 6.2 0.0 0.0 3.3 2.7 86.3 11.2 0.0 0.0 0.9 21.0 2.8 0.9 1.7 0.0 18.5 56.6 0.0 12.1 15.1 1.6 17.7 45.9 25.7 0.0 1.1 45.3 3.8 0.0 14.9 0.9 10.2 15.1 54.0 10.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 2.6 4.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.7 0.0 0.0 303.3 0.0 0.0 0.2 0.2 6.7 0.2 0.0 0.1 0.3 0.5 3.8 0.0 0.1 0.0 1.8 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1115.4 0.0 0.7 0.0 0.1 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.1 0.4 0.0 0.2 0.0 0.0 2.9 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 32.1 163.9 0.0 0.5 1.7 0.4 0.0 0.0 0.0 0.0 0.0 0.3 0.0 17.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 3.7 0.0 16.0 0.0 1.6 0.0 3.5 0.5 0.0 4422.8 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 5.0 1.8 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 6.7 0.3 0.0 0.0 8.7 0.0 0.0 0.2 0.3 0.0 0.0 0.0 1.3 0.0 41.7 0.0 0.0 0.3 CPA4 CPA3 ENSG00000128510 "Carboxypeptidase A4" Q9UI42 7 130293134-130324180 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 21.6;skin 1: 57.1" "Cell type enhanced" "Detected in some" "Basal keratinocytes: 17.7;Basal respiratory cells: 23.7;Exocrine glandular cells: 54.1;Fibroblasts: 11.5;Suprabasal keratinocytes: 31.0" "Cancer enhanced" "Detected in many" "cervical cancer: 10.0;head and neck cancer: 9.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ hTERT+: 140.1;hTERT-RPE1: 261.0;LHCN-M2: 284.2;U-2 OS: 151.0;U-87 MG: 272.7" "Not detected" "Not detected" "Not detected" "Not detected" HPA021030 Approved Nucleoplasm,Centrosome,Cytosol "Secreted in other tissues" NA Yes 390000 "Cluster 31: Skin - Epidermis development" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 1: Pancreatic cells - Digestion" Nucleoplasm "Centrosome, Cytosol" "HPA021030: AB_1846010" "unprognostic (7.60e-3)" "unprognostic (4.00e-2)" "unprognostic (1.59e-3)" "unprognostic (3.63e-3)" "unprognostic (2.24e-2)" "unprognostic (2.91e-2)" "unprognostic (2.78e-2)" "unprognostic (4.36e-3)" "unprognostic (3.23e-1)" "unprognostic (5.79e-2)" "unprognostic (2.37e-3)" "unprognostic (6.49e-2)" "unprognostic (6.21e-10)" "unprognostic (2.39e-1)" "unprognostic (1.67e-1)" "unprognostic (7.56e-2)" "prognostic unfavorable (1.31e-4)" 5.0 4.4 0.4 0.4 0.4 0.1 3.5 0.5 1.7 15.3 0.5 0.0 0.0 0.2 0.3 21.6 0.4 0.1 1.1 0.6 2.1 0.6 0.1 0.4 0.2 1.1 0.7 0.1 12.7 0.0 0.5 2.0 1.1 0.2 0.0 0.2 6.7 0.0 0.3 57.1 0.2 0.8 0.6 3.3 0.4 0.3 1.2 0.8 0.0 0.0 0.9 0.0 12.6 1.1 95.3 5.0 0.3 0.3 0.7 1.5 0.1 74.6 140.1 74.9 18.5 0.7 8.1 0.1 14.3 31.9 75.2 5.5 0.0 41.3 76.7 0.4 0.3 0.0 33.3 2.1 1.8 0.3 0.2 1.0 65.2 6.7 9.4 261.0 0.3 0.1 0.0 0.2 284.2 0.2 0.0 0.0 0.8 0.4 11.1 0.3 75.4 0.1 34.5 4.0 0.2 0.0 49.9 23.3 0.5 28.0 0.5 0.4 57.3 18.1 151.0 6.2 7.4 0.2 0.2 0.1 272.7 0.1 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.4 0.4 0.5 1.7 0.6 2.1 1.1 0.7 1.1 0.6 1.2 1.1 0.0 3.2 0.5 0.0 0.0 17.7 0.5 23.7 0.6 0.0 4.2 2.8 0.3 0.0 8.5 0.0 0.0 5.6 0.1 0.0 0.0 0.5 0.4 0.4 0.2 0.3 0.0 0.0 0.4 54.1 1.2 11.5 0.0 2.0 0.0 0.0 0.7 0.0 0.1 0.0 0.1 0.0 0.0 0.0 1.2 0.2 0.0 0.3 3.6 1.0 0.6 0.0 0.0 0.0 0.5 7.9 0.0 0.0 0.0 0.9 0.0 0.1 2.9 0.0 0.0 1.3 0.4 0.1 0.7 10.0 31.0 9.4 0.1 0.0 0.0 1.6 CPA5 ENSG00000158525 "Carboxypeptidase A5" Q8WXQ8 7 130344816-130368730 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 15 "testis: 33.6" "Group enriched" "Detected in some" 23 "Early spermatids: 76.1;Late spermatids: 144.1" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Group enriched" "Detected in some" 4 "memory CD4 T-cell: 16.8;naive CD8 T-cell: 42.5;T-reg: 56.4" "Lineage enriched" "Detected in single" 102 "T-cells: 56.4" "Cell line enhanced" "Detected in some" "RH-30: 7.3;RT4: 3.4;U-266/84: 6.0" "Not detected" "Not detected" HPA020322 Approved Nucleoplasm "Secreted in male reproductive system" NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 83: Testis - Spermatogenesis" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "HPA020322: AB_10960562" "unprognostic (2.44e-1)" "unprognostic (3.76e-1)" "unprognostic (1.50e-1)" "unprognostic (5.94e-2)" "unprognostic (4.96e-2)" "unprognostic (7.10e-3)" "unprognostic (1.64e-2)" "unprognostic (1.41e-2)" "unprognostic (3.26e-1)" "unprognostic (5.02e-2)" "unprognostic (5.83e-4)" "unprognostic (1.43e-1)" "unprognostic (8.88e-13)" "unprognostic (5.16e-2)" "unprognostic (1.32e-1)" "unprognostic (8.81e-2)" "unprognostic (3.08e-2)" 0.3 0.2 0.3 0.1 0.2 0.2 0.1 0.2 1.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.5 0.2 0.0 0.0 1.9 0.3 0.4 0.0 0.5 0.0 1.2 0.6 0.4 0.1 0.0 0.0 0.0 0.0 0.2 1.0 0.7 0.0 0.2 1.8 0.0 33.6 0.5 2.2 0.3 0.0 0.9 0.6 0.0 0.4 0.5 0.0 0.0 0.4 0.0 0.0 0.0 0.3 2.1 0.1 0.2 1.6 0.0 0.0 0.0 0.0 0.7 0.0 0.2 0.4 0.0 0.0 1.2 0.5 0.5 0.8 0.3 0.0 0.0 0.0 0.7 0.0 0.9 0.9 0.0 0.6 0.0 1.0 0.0 0.0 0.3 0.0 0.4 0.0 0.0 0.0 7.3 0.2 1.0 3.4 0.9 0.1 0.0 2.0 0.0 0.1 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 6.0 0.0 0.3 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.6 0.0 16.8 8.6 0.0 0.0 4.2 42.5 0.0 0.0 0.0 0.0 56.4 5.8 0.3 0.2 0.2 1.0 0.4 0.5 0.3 0.4 0.4 0.2 0.5 0.4 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.8 0.6 0.3 0.0 0.0 1.8 0.0 3.1 0.0 0.0 0.0 0.1 76.1 0.2 0.0 0.1 0.0 0.0 0.1 0.2 0.2 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 144.1 0.9 0.1 0.0 0.0 0.9 0.0 2.1 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.1 0.0 0.0 0.0 2.1 0.0 3.8 2.6 0.0 0.0 4.7 4.0 0.0 0.0 0.1 CPA6 CPAH ENSG00000165078 "Carboxypeptidase A6" Q8N4T0 8 67422038-67746378 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 2.3;prostate: 2.7;retina: 2.2" "Cell type enhanced" "Detected in some" "Basal prostatic cells: 31.7;Early spermatids: 21.7;Microglial cells: 12.2;Muller glia cells: 22.5;Pancreatic endocrine cells: 21.5;Paneth cells: 12.8;Prostatic glandular cells: 11.3;Urothelial cells: 36.6" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CACO-2: 2.5;EFO-21: 1.5;Hep G2: 3.4;OE19: 1.5" "Region enriched" "Detected in some" 9 "olfactory bulb: 12.6" "Low region specificity" "Detected in all" "Secreted to extracellular matrix" NA NA "Cluster 37: Intestine - Unknown function" "Cluster 39: CACO-2 - Unknown function" "Cluster 22: Epithelial cell types - Mixed function" "unprognostic (2.85e-2)" "unprognostic (1.95e-1)" "unprognostic (1.72e-2)" "unprognostic (1.14e-1)" "unprognostic (2.58e-1)" "unprognostic (2.24e-1)" "unprognostic (2.08e-1)" "unprognostic (2.88e-1)" "unprognostic (9.35e-2)" "unprognostic (1.65e-1)" "unprognostic (5.23e-2)" "unprognostic (6.99e-2)" "unprognostic (3.57e-4)" "unprognostic (9.61e-5)" "unprognostic (1.75e-1)" "unprognostic (9.09e-2)" "unprognostic (1.41e-2)" 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.6 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 2.3 2.2 0.0 0.2 0.0 0.0 0.2 0.8 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.0 1.2 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 1.5 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.0 31.7 0.0 5.7 0.2 0.1 0.4 0.2 0.0 0.1 0.0 0.0 0.0 0.0 2.3 0.0 0.0 21.7 0.1 0.0 0.1 2.4 0.0 1.6 0.4 0.0 0.4 0.0 0.7 0.0 0.0 0.0 0.0 0.1 1.7 1.3 2.2 0.0 0.0 0.0 3.2 1.8 0.2 0.0 12.2 0.1 22.5 0.0 3.0 1.3 21.5 12.8 0.0 0.0 11.3 0.0 0.0 0.0 1.0 0.0 0.1 0.3 0.0 0.0 0.8 0.0 0.0 0.6 0.0 5.7 36.6 CPB1 ENSG00000153002 "Carboxypeptidase B1" P15086 3 148791102-148860187 "Enzymes, Plasma proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 1970 "pancreas: 226925.8" "Cell type enriched" "Detected in some" 12 "Exocrine glandular cells: 7306.0" "Group enriched" "Detected in some" 312 "breast cancer: 293.8;pancreatic cancer: 641.4" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "basophil: 4.0" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "HDLM-2: 1.0;U-2 OS: 1.8" "Not detected" "Not detected" "Not detected" "Not detected" "CAB026158, HPA038069, HPA046340" Enhanced "Secreted to digestive system" NA NA 88000000 "Cluster 17: Basophils - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 9: U-2 OS - Unknown function" "Cluster 1: Pancreatic cells - Digestion" "CAB026158: , HPA038069: AB_2675816, HPA046340: AB_2679628" "unprognostic (6.90e-2)" "unprognostic (3.79e-2)" "unprognostic (3.34e-2)" "unprognostic (2.64e-2)" "unprognostic (5.58e-2)" "unprognostic (3.27e-2)" "unprognostic (6.26e-4)" "unprognostic (1.90e-1)" "unprognostic (1.82e-1)" "unprognostic (1.07e-1)" "unprognostic (7.59e-2)" "unprognostic (4.51e-2)" "unprognostic (5.50e-8)" "unprognostic (3.08e-1)" "unprognostic (1.60e-1)" "unprognostic (4.93e-2)" 15.7 83.0 0.4 5.1 1.7 2.5 78.3 0.6 1.4 6.0 0.1 2.6 31.2 4.7 0.3 3.5 1.8 0.1 40.8 0.6 0.8 2.0 7.1 1.7 8.1 1.0 1.2 115.1 226925.8 0.0 2.1 13.7 1.1 4.7 4.5 0.0 36.3 0.0 2.2 2.8 17.2 0.0 0.4 19.2 28.3 2.9 1.2 0.1 1.6 0.0 0.0 1.4 2.0 3.3 0.0 0.0 0.0 0.0 0.9 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.9 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.5 0.0 0.9 0.2 0.0 0.0 0.0 4.0 0.3 0.5 1.3 0.4 0.9 0.4 0.5 1.1 0.1 0.7 0.3 1.4 1.9 1.4 0.5 0.5 0.3 0.4 0.4 1.7 0.6 1.4 0.6 0.8 1.0 1.2 1.1 0.4 1.2 3.3 2.2 0.0 0.0 1.0 0.0 0.6 0.5 0.0 0.0 0.0 8.7 1.9 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 11.6 11.2 0.0 0.1 1.1 164.9 1.3 0.3 7306.0 0.0 36.8 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.2 0.2 0.0 0.0 1.0 2.5 0.6 1.5 0.0 0.0 18.1 0.0 0.0 0.0 29.8 590.0 0.1 0.0 0.0 4.6 0.0 0.0 0.0 0.0 0.0 4.2 2.5 0.0 1.1 0.1 0.3 0.3 0.3 1.1 0.2 0.2 CPB2 "CPU, PCPB, TAFI" ENSG00000080618 "Carboxypeptidase B2" Q96IY4 13 46053186-46105033 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Blood coagulation, Fibrinolysis, Hemostasis" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 84 "liver: 1484.1" "Cell type enriched" "Detected in some" 7 "Hepatocytes: 1332.7" "Cancer enriched" "Detected in some" 112 "liver cancer: 268.4" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 86 "Hep G2: 173.2" "Not detected" "Not detected" "Not detected" "Not detected" HPA004146 Approved "Secreted to blood" NA NA 8500000000 "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" "HPA004146: AB_1078397" "unprognostic (3.44e-2)" "unprognostic (1.25e-1)" "unprognostic (2.94e-2)" "unprognostic (1.89e-2)" "unprognostic (7.69e-2)" "unprognostic (1.17e-2)" "prognostic favorable (2.06e-4)" "unprognostic (1.89e-1)" "unprognostic (2.74e-1)" "unprognostic (2.48e-1)" "unprognostic (3.17e-2)" "unprognostic (4.83e-2)" "unprognostic (3.20e-3)" "unprognostic (1.34e-1)" "unprognostic (7.10e-2)" "unprognostic (3.34e-2)" "unprognostic (9.61e-2)" 0.1 0.0 0.5 0.1 3.1 0.7 0.1 0.6 1.8 0.0 0.0 0.0 0.0 0.0 6.3 0.0 0.0 4.8 0.0 0.5 1.4 0.4 1484.1 17.6 0.1 1.7 2.0 0.0 0.5 0.0 0.0 0.0 2.5 0.1 0.0 0.4 0.1 0.2 0.2 0.1 0.1 0.0 0.3 0.4 0.1 0.2 2.2 0.0 0.1 0.0 0.0 0.0 0.0 5.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.3 0.0 0.6 0.3 173.2 0.0 0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.2 0.2 0.0 0.1 0.2 0.2 0.2 0.0 0.0 0.0 0.5 0.2 0.0 0.1 0.0 0.1 0.1 0.0 2.0 0.1 0.1 0.1 0.0 0.1 0.1 0.0 0.0 0.2 0.5 0.3 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.5 3.1 0.6 1.8 0.5 1.4 1.7 2.0 2.5 0.3 2.2 5.1 0.0 3.2 27.0 3.9 1.7 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.1 190.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.3 0.1 1.0 0.0 10.7 4.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 15.7 1332.7 0.1 0.0 5.3 0.0 0.0 22.7 0.0 0.1 0.0 0.0 0.0 1.0 0.0 0.0 0.0 13.0 36.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 CPD GP180 ENSG00000108582 "Carboxypeptidase D" O75976 17 30378927-30469989 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 25.0" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA052796, HPA055465" Approved Approved "Nucleoplasm,Nuclear membrane,Nuclear speckles" NA NA 1700000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 1: Thyroid gland - Transcription" "Cluster 21: OE19 - Mitochondria" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Nucleoplasm, Nuclear speckles" "Nuclear membrane" "HPA052796: AB_2681953, HPA055465: AB_2682823" "unprognostic (1.05e-1)" "unprognostic (1.31e-1)" "unprognostic (3.05e-2)" "unprognostic (3.62e-2)" "unprognostic (6.13e-2)" "unprognostic (1.65e-1)" "unprognostic (7.97e-3)" "unprognostic (4.45e-2)" "unprognostic (2.07e-2)" "unprognostic (2.96e-1)" "unprognostic (1.62e-1)" "unprognostic (3.16e-1)" "unprognostic (1.58e-1)" "unprognostic (3.74e-2)" "unprognostic (7.25e-2)" "unprognostic (3.36e-1)" "unprognostic (1.08e-1)" 25.9 7.4 10.8 19.7 13.1 32.2 20.5 15.4 25.6 40.9 9.4 18.0 20.3 15.8 13.2 12.1 23.0 31.8 9.1 11.8 13.0 19.7 25.4 18.2 7.9 19.5 13.3 7.8 15.7 28.5 6.1 30.3 17.8 16.8 20.1 14.9 44.8 11.2 8.1 8.2 19.8 23.3 18.3 9.3 37.3 41.3 13.5 8.3 57.6 14.0 9.9 18.3 7.1 28.0 39.4 58.9 50.0 51.6 51.0 95.9 18.0 53.1 77.2 36.0 43.9 69.6 24.9 5.1 65.8 61.3 45.6 27.6 32.7 67.1 60.3 18.7 46.7 11.2 32.5 43.2 61.8 73.8 28.3 172.3 29.4 46.2 44.3 59.7 74.3 16.5 22.1 56.1 29.2 7.7 23.9 20.3 14.1 89.8 13.4 22.6 57.8 15.3 67.3 44.2 12.5 31.5 63.4 54.0 27.6 58.0 51.2 50.4 89.2 35.7 23.3 56.2 51.3 22.5 50.0 16.1 45.6 47.2 30.9 4.5 7.7 8.4 4.1 3.6 4.5 0.2 2.1 3.5 4.4 0.4 1.6 2.0 25.0 2.7 3.2 0.5 1.5 3.6 10.8 13.1 15.4 25.6 11.8 13.0 19.5 13.3 17.8 18.3 13.5 28.0 124.4 32.1 23.9 28.4 7.5 22.0 34.2 99.2 21.6 30.8 34.9 18.8 13.7 155.8 129.5 29.5 45.9 24.8 35.9 37.8 1.9 32.4 96.1 21.9 24.9 51.9 32.3 15.6 62.9 24.8 11.1 25.6 72.4 35.2 24.1 21.6 56.0 93.9 15.9 47.1 57.1 69.0 85.5 31.2 20.4 56.0 16.8 33.7 30.2 90.9 32.9 13.4 29.9 45.8 164.5 32.8 26.4 16.1 38.1 58.5 50.1 18.5 84.2 33.8 0.0 21.3 23.4 31.0 21.0 21.1 18.6 24.1 35.6 14.2 34.4 50.7 CPE ENSG00000109472 "Carboxypeptidase E" P16870 4 165361194-165498547 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 643.3;retina: 741.7" "Cell type enhanced" "Detected in many" "Astrocytes: 727.4;Bipolar cells: 569.1;Cone photoreceptor cells: 621.3;Enteroendocrine cells: 587.4;Leydig cells: 500.8;Muller glia cells: 530.9;Peritubular cells: 621.0;Rod photoreceptor cells: 803.3;Sertoli cells: 854.6;Smooth muscle cells: 519.4" "Cancer enhanced" "Detected in all" "glioma: 240.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "Hep G2: 311.6;SCLC-21H: 418.2;SiHa: 629.0;SuSa: 342.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003819, CAB024907" Supported Approved Nucleoplasm,Vesicles,Centrosome "Intracellular and membrane" NA NA 600000 "Cluster 77: Retina - Visual perception" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 48: Smooth muscle cells - ECM organization" Centrosome "Nucleoplasm, Vesicles" "CAB024907: , HPA003819: AB_2667054" "unprognostic (1.84e-1)" "unprognostic (5.64e-3)" "unprognostic (1.61e-1)" "unprognostic (1.70e-2)" "unprognostic (2.51e-1)" "unprognostic (1.44e-2)" "unprognostic (1.65e-1)" "unprognostic (9.52e-2)" "unprognostic (2.91e-3)" "unprognostic (9.01e-2)" "unprognostic (4.84e-3)" "unprognostic (5.56e-3)" "prognostic unfavorable (2.60e-4)" "unprognostic (4.35e-3)" "unprognostic (1.46e-1)" "unprognostic (2.26e-1)" "prognostic unfavorable (2.12e-4)" 138.1 151.7 554.8 20.5 593.0 1.8 97.5 550.9 604.0 53.9 311.9 44.6 22.0 67.7 404.6 74.8 88.6 65.7 100.7 584.3 643.3 68.4 26.7 50.1 37.5 417.0 494.2 104.0 170.4 89.9 328.4 7.7 456.2 295.1 36.8 741.7 104.5 84.7 56.2 45.1 30.7 83.3 448.3 11.6 80.2 146.2 578.2 68.8 179.7 47.5 35.2 33.8 73.4 446.2 0.2 8.4 54.4 10.5 41.4 4.5 2.4 0.1 21.5 8.1 16.5 0.0 0.5 0.0 15.8 0.6 1.9 1.2 20.4 4.4 4.7 0.3 78.6 0.0 21.6 311.6 3.0 0.3 0.5 102.3 21.5 0.3 0.4 104.0 0.2 0.0 0.1 2.1 11.2 15.4 0.4 2.7 34.4 0.2 12.1 0.3 0.2 1.1 0.7 3.4 418.2 138.0 629.0 77.9 0.0 342.6 46.7 1.9 0.0 16.7 42.5 1.5 1.5 23.5 0.6 2.2 15.5 0.7 5.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 554.8 593.0 550.9 604.0 584.3 643.3 417.0 494.2 456.2 448.3 578.2 446.2 87.1 0.0 5.6 727.4 0.6 26.1 81.7 10.3 66.0 569.1 25.6 52.1 54.5 54.3 5.0 22.0 621.3 0.6 1.4 2.9 0.0 19.7 6.7 2.2 12.1 130.4 587.4 2.7 234.8 1.8 0.3 249.0 31.6 1.3 0.0 8.6 274.2 15.1 1.0 70.7 129.0 16.2 38.7 5.4 41.2 23.3 500.8 6.3 87.2 94.6 1.0 530.9 0.0 211.6 23.0 12.4 3.7 621.0 0.7 434.6 10.2 12.7 1.2 803.3 854.6 14.1 519.4 19.7 13.3 14.0 20.9 0.8 5.5 15.4 4.0 18.9 CPM ENSG00000135678 "Carboxypeptidase M" P14384 12 68842197-68971570 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 156.1" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 359.0;Alveolar cells type 2: 362.2;Kupffer cells: 368.5;Sertoli cells: 762.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "classical monocyte: 21.0;intermediate monocyte: 14.5;myeloid DC: 16.6;non-classical monocyte: 7.4" "Group enriched" "Detected in many" 5 "dendritic cells: 16.6;monocytes: 21.0" "Group enriched" "Detected in many" 4 "ASC diff: 71.1;ASC TERT1: 50.0;HSkMC: 91.2;SiHa: 68.9;THP-1: 26.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002657, HPA077243" Enhanced Uncertain Vesicles NA NA 7100000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 82: Adipose tissue - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 4: Macrophages - Innate immune response" Vesicles "HPA002657: AB_1078398, HPA077243: " "unprognostic (1.74e-1)" "unprognostic (3.11e-1)" "unprognostic (2.88e-3)" "prognostic favorable (1.00e-4)" "unprognostic (4.58e-2)" "unprognostic (8.61e-2)" "unprognostic (1.57e-2)" "unprognostic (2.01e-1)" "unprognostic (8.42e-2)" "unprognostic (1.40e-1)" "unprognostic (1.35e-1)" "unprognostic (1.42e-1)" "unprognostic (1.47e-3)" "unprognostic (8.58e-2)" "unprognostic (6.85e-2)" "unprognostic (2.59e-2)" "unprognostic (1.06e-1)" 156.1 11.5 6.4 14.4 13.3 3.5 40.2 10.1 10.5 14.4 3.8 33.5 4.4 23.9 0.9 10.1 16.2 16.1 4.6 7.6 10.2 41.3 26.5 59.3 16.1 19.3 11.5 18.0 13.0 12.0 1.0 70.1 11.9 14.7 26.6 6.7 4.1 2.8 5.8 21.7 5.9 6.4 7.5 19.4 15.3 5.4 28.0 4.3 7.5 9.7 10.5 9.3 5.7 23.5 0.1 4.0 0.1 0.0 71.1 50.0 0.7 9.8 1.1 1.7 2.3 3.2 4.1 0.5 9.6 1.4 4.1 0.0 1.4 2.7 4.1 0.1 2.7 0.0 15.1 0.3 0.4 1.2 1.9 91.2 0.6 1.0 2.0 8.6 0.0 0.3 0.0 0.1 7.3 1.7 0.0 0.7 1.7 0.0 5.2 3.1 0.6 0.0 7.2 5.9 0.4 0.2 68.9 10.7 7.9 5.5 1.2 26.5 0.2 1.2 7.5 0.5 0.2 0.4 0.5 13.1 4.3 13.1 5.9 0.6 21.0 0.1 0.2 14.5 0.0 1.8 1.5 0.1 16.6 3.5 0.9 0.2 1.6 0.5 7.4 1.1 1.9 7.3 6.4 13.3 10.1 10.5 7.6 10.2 19.3 11.5 11.9 7.5 28.0 23.5 83.3 359.0 362.2 34.6 4.9 12.4 3.5 6.1 0.6 3.3 7.8 8.9 2.6 135.8 70.1 51.5 0.0 32.3 1.1 97.5 29.4 57.9 16.6 100.9 8.3 29.0 10.8 3.6 1.2 212.5 59.9 14.1 4.6 237.1 112.5 6.7 73.9 36.6 134.6 0.0 1.3 28.7 0.0 368.5 36.3 17.5 105.0 202.2 10.6 19.7 23.3 68.9 1.0 23.1 161.8 68.0 65.9 79.0 2.4 38.7 1.9 63.7 16.4 5.7 762.6 7.2 126.9 0.6 3.9 2.4 9.9 172.4 14.5 46.3 32.7 2.8 CPN1 ENSG00000120054 "Carboxypeptidase N subunit 1" P15169 10 100042193-100081869 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 54 "liver: 81.6" "Cell type enriched" "Detected in some" 4 "Hepatocytes: 37.2" "Group enriched" "Detected in some" 12 "liver cancer: 26.6;melanoma: 7.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 17 "SK-MEL-30: 141.8" "Low region specificity" "Detected in some" "Not detected" "Not detected" "Secreted to blood" NA NA 13000000000 "Cluster 62: Liver - Hemostasis" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 15: Hepatocytes - Hemostasis" "unprognostic (2.97e-2)" "unprognostic (2.23e-2)" "unprognostic (3.93e-2)" "unprognostic (1.64e-1)" "unprognostic (6.75e-2)" "unprognostic (2.93e-2)" "unprognostic (5.26e-2)" "unprognostic (2.63e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 81.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 141.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 37.2 0.0 0.0 0.4 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 7.6 4.4 0.0 0.0 0.1 0.1 0.0 0.2 0.0 CPO ENSG00000144410 "Carboxypeptidase O" Q8IVL8 2 206939518-206969474 "Enzymes, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 15 "intestine: 111.8" "Cell type enriched" "Detected in some" 8 "Proximal enterocytes: 349.9" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 30 "basophil: 12.0" "Lineage enriched" "Detected in single" 84 "granulocytes: 12.0" "Cell line enhanced" "Detected in single" "NB-4: 1.0" "Not detected" "Not detected" "Intracellular and membrane" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 56: Intestine - Transmembrane transport" "Cluster 24: NB-4 - Immune response" "Cluster 45: Enterocytes - Digestion" "unprognostic (9.39e-2)" "unprognostic (2.64e-1)" "unprognostic (2.95e-2)" "unprognostic (5.21e-2)" "unprognostic (2.28e-1)" "unprognostic (1.27e-2)" "unprognostic (1.16e-1)" "unprognostic (9.06e-2)" "unprognostic (4.03e-1)" "unprognostic (1.33e-1)" "unprognostic (3.75e-3)" "unprognostic (1.22e-1)" "unprognostic (3.60e-2)" "unprognostic (2.52e-1)" "unprognostic (6.56e-2)" "unprognostic (4.03e-2)" "unprognostic (4.89e-2)" 0.7 1.0 2.4 0.1 2.4 0.0 0.8 1.3 3.1 0.5 1.2 1.2 0.5 0.3 7.5 0.2 0.7 0.4 0.4 2.2 2.3 1.3 0.7 0.3 0.1 2.0 2.1 0.4 0.5 1.0 1.2 0.2 2.3 0.9 0.4 0.6 0.8 0.8 0.7 0.5 111.8 0.7 2.1 0.2 0.5 0.8 2.4 0.1 1.0 0.5 0.1 0.5 0.3 3.3 0.0 0.0 0.0 0.0 0.7 0.2 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.6 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.2 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.1 12.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 2.4 1.3 3.1 2.2 2.3 2.0 2.1 2.3 2.1 2.4 3.3 0.1 0.0 0.0 9.1 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.1 0.2 0.0 0.0 0.0 43.6 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 35.9 6.3 0.0 0.0 0.0 0.7 0.3 0.0 0.0 6.5 0.0 0.0 0.0 2.0 14.6 0.0 3.8 0.0 0.0 0.0 349.9 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.1 CPQ "LDP, PGCP" ENSG00000104324 "Carboxypeptidase Q" Q9Y646 8 96645242-97149654 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "thyroid gland: 225.9" "Cell type enhanced" "Detected in all" "Astrocytes: 150.2;Oligodendrocytes: 299.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 250.5" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC diff: 116.1;ASC TERT1: 131.4;hTERT-RPE1: 108.2;Karpas-707: 97.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023235, HPA024490" Enhanced Supported "Golgi apparatus,Vesicles" "Secreted to blood" NA NA 51000000 "Cluster 50: Neutrophils - Cellular senescence" "Cluster 1: Thyroid gland - Transcription" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Golgi apparatus, Vesicles" "HPA023235: AB_1855257, HPA024490: AB_1855258" "unprognostic (4.04e-2)" "unprognostic (5.46e-2)" "unprognostic (4.45e-2)" "unprognostic (1.68e-1)" "unprognostic (1.51e-3)" "unprognostic (3.98e-3)" "unprognostic (5.24e-2)" "unprognostic (2.92e-2)" "unprognostic (2.67e-2)" "unprognostic (9.19e-2)" "unprognostic (2.38e-3)" "unprognostic (6.16e-3)" "prognostic favorable (5.40e-5)" "unprognostic (6.74e-3)" "unprognostic (8.71e-2)" "unprognostic (3.21e-2)" "unprognostic (1.75e-1)" 46.2 35.9 22.6 25.4 33.9 31.8 34.7 28.0 26.7 75.1 20.6 39.6 29.3 46.0 36.2 25.9 39.8 57.8 51.8 21.6 27.0 80.5 70.0 32.3 22.8 32.6 27.5 87.4 46.7 60.7 25.6 39.2 33.2 40.2 33.1 16.8 32.8 54.2 13.3 20.6 35.0 64.7 25.9 31.3 32.1 13.9 30.3 8.2 225.9 33.2 17.0 46.3 38.6 38.6 0.6 2.1 2.1 0.1 116.1 131.4 0.5 35.3 55.6 12.8 26.5 2.0 0.9 0.4 27.2 59.0 15.7 1.0 2.4 2.8 12.0 31.4 4.4 28.4 1.5 17.7 25.6 4.9 37.0 69.6 6.5 15.0 3.7 108.2 6.0 0.1 27.1 97.0 29.4 1.2 0.5 14.1 2.5 0.2 5.2 4.3 0.0 0.6 26.7 13.2 2.4 0.3 10.2 0.4 28.2 25.8 12.3 28.6 21.3 51.9 4.9 0.8 11.5 7.9 0.9 0.3 32.2 21.6 33.5 32.0 71.3 45.1 27.3 49.6 27.6 5.4 20.3 24.0 51.8 7.4 17.6 24.6 250.5 25.9 47.5 14.8 22.2 40.6 22.6 33.9 28.0 26.7 21.6 27.0 32.6 27.5 33.2 25.9 30.3 38.6 46.6 12.8 12.5 150.2 11.7 19.4 25.7 21.3 9.6 12.7 12.1 27.9 27.2 42.9 13.9 47.8 29.2 12.1 40.8 9.3 17.6 22.7 5.0 6.6 43.3 27.1 13.8 7.2 24.0 10.7 1.8 123.8 10.7 8.6 38.0 43.1 51.0 48.3 54.0 10.1 31.3 7.9 24.4 56.0 44.9 9.0 72.4 39.4 78.2 131.2 33.7 43.4 39.1 44.7 299.6 11.7 9.5 73.0 11.9 12.4 42.4 56.0 9.7 16.3 52.6 71.1 67.8 5.6 3.4 2.8 13.1 6.0 23.8 38.6 12.2 13.5 CPXM1 "CPX-1, CPX1, CPXM" ENSG00000088882 "Carboxypeptidase X, M14 family member 1" Q96SM3 20 2794074-2800627 "Enzymes, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 86.0" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 162.7;Fibroblasts: 60.1;Theca cells: 28.2" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in many" 5 "cerebral cortex: 6.9" "Immune cell enhanced" "Detected in single" "NK-cell: 1.3" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "AF22: 161.7;HSkMC: 85.7;NB-4: 148.1;REH: 150.8;SH-SY5Y: 108.2" "Low region specificity" "Detected in all" "Region enhanced" "Detected in many" "spinal cord: 8.7" "Secreted in other tissues" NA NA 490000 "Cluster 48: NK-cells - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 12: NES - Nervous system development" "Cluster 36: Stromal cells - Cell proliferation" "unprognostic (7.48e-2)" "unprognostic (3.61e-1)" "unprognostic (6.70e-2)" "unprognostic (1.47e-2)" "unprognostic (3.41e-1)" "unprognostic (5.24e-2)" "unprognostic (1.82e-2)" "unprognostic (1.84e-2)" "unprognostic (2.98e-2)" "unprognostic (9.32e-2)" "unprognostic (7.02e-2)" "unprognostic (3.23e-2)" "prognostic unfavorable (4.62e-10)" "unprognostic (1.30e-1)" "unprognostic (1.49e-1)" "unprognostic (5.55e-3)" "unprognostic (1.27e-2)" 59.0 4.8 0.9 9.7 1.2 19.0 31.2 0.7 6.9 72.4 2.5 4.1 1.4 76.8 8.4 4.2 27.1 86.0 4.5 0.9 0.9 6.5 0.3 5.4 6.5 0.9 0.7 41.9 3.1 3.8 5.3 51.5 1.1 7.1 1.5 0.0 4.8 2.3 1.2 12.7 3.3 38.8 1.1 0.9 2.2 3.6 1.4 9.6 24.5 0.0 2.8 55.5 29.4 1.0 0.0 0.0 161.7 0.0 0.0 4.9 0.2 0.4 0.7 2.0 0.6 0.0 0.0 0.0 0.5 0.3 0.1 0.0 12.1 0.0 0.5 0.7 8.5 22.1 0.0 0.0 2.2 0.1 3.2 85.7 0.0 7.7 0.0 0.0 0.0 31.1 9.3 0.0 0.1 0.1 0.6 148.1 34.5 0.0 0.0 150.8 0.0 4.2 0.0 0.0 0.2 108.2 0.0 0.2 0.0 25.8 0.0 1.9 0.1 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 4.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.4 0.0 0.0 0.0 0.0 1.3 0.0 0.3 0.0 0.2 0.9 1.2 0.7 6.9 0.9 0.9 0.9 0.7 1.1 1.1 1.4 1.0 3.9 0.0 0.5 0.0 0.3 2.7 5.8 0.7 4.0 0.0 1.1 3.8 0.7 0.0 0.8 3.7 0.0 2.9 1.7 0.5 0.0 3.0 2.3 5.8 162.7 3.1 0.0 7.6 0.0 0.0 3.3 60.1 0.0 4.2 2.5 17.7 0.7 0.0 6.5 0.0 0.0 0.0 0.0 0.0 2.6 2.8 17.4 0.9 1.8 0.0 0.7 0.0 0.0 0.5 0.0 0.3 0.0 0.7 0.5 2.5 0.0 0.1 3.1 0.0 0.0 0.4 10.2 0.0 1.5 0.1 2.0 3.3 1.4 28.2 0.6 0.8 CPXM2 "CPX2, UNQ676" ENSG00000121898 "Carboxypeptidase X, M14 family member 2" Q8N436 10 123706207-123940267 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 81.3;intestine: 75.4" "Cell type enhanced" "Detected in many" "Early spermatids: 106.8;Late spermatids: 202.5;Oligodendrocytes: 35.6;Peritubular cells: 79.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 17 "BJ: 18.4;fHDF/TERT166: 71.8;SuSa: 28.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA048375 Uncertain "Secreted - unknown location" NA NA 62000 "Cluster 57: Non-specific - Angiogenesis" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "HPA048375: AB_2680377" "unprognostic (1.50e-1)" "unprognostic (3.66e-1)" "unprognostic (2.58e-2)" "unprognostic (4.02e-3)" "unprognostic (2.69e-2)" "unprognostic (6.48e-2)" "unprognostic (1.32e-2)" "unprognostic (1.32e-2)" "unprognostic (1.26e-1)" "unprognostic (8.57e-2)" "unprognostic (4.42e-2)" "unprognostic (2.14e-1)" "prognostic favorable (9.02e-4)" "unprognostic (3.48e-2)" "unprognostic (2.54e-2)" "unprognostic (1.27e-1)" "unprognostic (1.16e-3)" 29.1 6.4 3.9 5.9 7.2 0.0 20.8 9.2 2.6 5.8 81.3 75.4 6.2 10.2 59.8 18.4 16.0 11.2 18.0 3.5 7.2 11.2 2.4 7.0 2.7 16.1 10.7 16.7 5.2 2.5 10.9 1.2 11.6 15.1 7.0 0.5 9.3 12.7 3.8 7.3 14.9 56.9 20.0 16.8 19.9 9.6 10.4 7.8 15.0 7.9 6.6 28.3 9.2 18.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 18.4 0.7 1.1 0.1 0.0 0.0 0.0 0.0 71.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 2.2 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.2 0.1 28.0 0.5 0.0 0.0 0.1 0.1 0.3 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.9 7.2 9.2 2.6 3.5 7.2 16.1 10.7 11.6 20.0 10.4 18.3 22.3 0.0 0.6 0.3 0.1 2.2 0.0 0.2 6.2 0.0 0.3 0.4 2.4 0.0 0.0 1.8 0.0 8.3 0.1 0.2 1.9 0.4 106.8 0.2 0.2 26.1 0.0 0.0 5.0 0.2 0.3 23.0 1.1 0.3 0.0 0.1 16.8 0.0 0.3 1.7 0.5 0.7 0.0 0.0 2.7 202.5 10.8 0.6 3.6 0.0 0.0 0.0 0.0 1.0 35.6 0.1 0.1 79.0 1.4 0.0 0.4 0.0 0.0 0.1 0.0 1.6 2.0 1.3 1.9 0.6 2.0 5.1 0.2 0.0 2.7 0.2 CPZ ENSG00000109625 "Carboxypeptidase Z" Q66K79 4 8592660-8619759 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Wnt signaling pathway" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "ovary: 144.3" "Cell type enhanced" "Detected in some" "Endometrial stromal cells: 1.5;Fibroblasts: 8.5;Microglial cells: 2.8" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 73.6;BJ: 39.7;BJ hTERT+: 51.7;hTERT-RPE1: 30.6;RH-30: 57.6;U-2197: 46.0" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA078608 Approved "Plasma membrane" "Secreted to extracellular matrix" NA NA "Cluster 89: Fibroblasts - ECM organization" "Cluster 28: BEWO - Transcription regulation" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane" "HPA078608: " "unprognostic (2.58e-1)" "unprognostic (7.16e-2)" "unprognostic (4.83e-2)" "unprognostic (1.42e-1)" "unprognostic (7.77e-2)" "unprognostic (2.20e-2)" "unprognostic (2.98e-1)" "unprognostic (7.77e-2)" "unprognostic (2.30e-1)" "unprognostic (1.95e-2)" "unprognostic (1.41e-1)" "unprognostic (1.59e-1)" "unprognostic (7.23e-8)" "unprognostic (4.30e-3)" "unprognostic (3.58e-2)" "unprognostic (6.13e-4)" "unprognostic (5.51e-2)" 11.1 1.8 0.3 2.7 1.0 0.0 11.8 0.5 2.9 33.3 2.3 4.6 0.8 14.6 9.1 7.4 19.9 30.7 2.8 0.8 0.4 2.0 1.4 7.1 2.8 0.7 0.5 144.3 3.2 1.8 5.2 42.1 0.8 5.9 1.8 0.1 1.5 24.2 0.2 13.8 2.6 8.4 1.2 1.4 3.3 3.1 0.3 1.5 7.8 0.0 1.0 23.0 25.1 0.9 26.1 0.4 0.0 1.6 5.0 0.5 73.6 39.7 51.7 14.5 5.8 1.7 0.7 0.0 3.7 21.3 0.3 0.0 0.0 0.0 5.4 0.0 2.9 0.0 0.3 0.7 4.4 0.0 0.0 9.2 0.0 0.0 0.0 30.6 0.0 0.0 1.2 0.0 0.9 6.1 0.0 0.1 9.2 0.2 22.0 0.1 57.6 0.0 0.0 1.1 0.1 0.1 1.4 0.5 0.1 8.3 0.3 0.0 0.0 2.0 2.6 46.0 0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.0 0.5 2.9 0.8 0.4 0.7 0.5 0.8 1.2 0.3 0.9 0.0 0.0 0.0 0.3 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.6 0.0 0.6 8.5 0.5 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.9 0.1 0.0 2.8 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 DNPEP "ASPEP, DAP" ENSG00000123992 "Aspartyl aminopeptidase" Q9ULA0 2 219372043-219400022 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 364.4;Late spermatids: 462.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036398, HPA044860" Enhanced Supported Cytosol NA NA 2700000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 28: BEWO - Transcription regulation" "Cluster 10: Non-specific - Unknown function" Cytosol "HPA036398: AB_10970915, HPA044860: AB_10961275" "unprognostic (3.71e-1)" "unprognostic (6.45e-2)" "unprognostic (1.26e-1)" "unprognostic (1.05e-2)" "unprognostic (1.55e-2)" "unprognostic (2.75e-1)" "unprognostic (2.54e-3)" "unprognostic (3.34e-2)" "unprognostic (2.44e-1)" "unprognostic (3.49e-2)" "unprognostic (1.61e-1)" "unprognostic (6.13e-2)" "unprognostic (1.67e-1)" "unprognostic (5.63e-3)" "unprognostic (3.49e-1)" "unprognostic (2.50e-1)" "unprognostic (1.85e-3)" 25.8 18.9 15.4 25.0 15.8 18.0 23.6 14.8 18.6 24.9 14.7 34.5 56.5 22.4 21.5 25.1 25.1 22.6 39.9 16.2 16.9 22.1 32.0 27.6 23.4 15.8 15.0 30.2 27.2 25.8 13.0 37.1 15.2 22.6 30.8 9.5 26.2 24.4 64.5 31.7 56.2 19.9 16.0 24.7 25.4 58.5 17.4 17.5 15.2 46.4 16.2 29.6 21.6 14.7 47.5 25.8 15.4 45.7 39.7 32.2 122.0 23.0 46.5 59.3 62.5 72.6 61.2 27.2 48.7 49.5 76.0 45.0 18.6 53.6 21.3 56.4 12.5 46.6 25.0 79.8 107.2 38.9 32.2 54.4 55.4 61.8 50.2 37.9 41.2 38.6 53.8 45.3 31.0 103.7 60.8 44.5 25.5 67.7 15.1 77.2 35.7 36.5 33.0 74.0 19.1 26.0 27.1 86.5 34.5 26.9 25.8 43.3 23.5 55.4 46.1 31.4 33.7 49.6 31.8 21.3 80.0 37.7 24.1 8.7 17.2 7.3 16.1 19.7 18.8 13.2 13.2 18.3 20.8 16.2 14.0 18.7 1.6 21.2 17.0 7.2 16.6 14.8 15.4 15.8 14.8 18.6 16.2 16.9 15.8 15.0 15.2 16.0 17.4 14.7 43.1 12.8 18.2 8.8 35.6 38.6 74.1 55.1 52.9 19.3 41.2 36.7 33.6 55.8 27.2 25.8 33.3 90.4 26.7 70.4 49.0 62.9 364.4 16.5 36.5 41.8 48.0 19.8 3.1 66.3 96.9 43.4 29.0 19.6 24.1 39.1 30.4 47.9 51.0 10.1 5.2 110.3 38.7 31.5 26.8 462.0 52.5 26.2 32.0 4.7 53.0 29.8 45.3 3.0 3.3 52.3 75.6 41.0 38.3 113.1 202.6 79.6 16.3 37.6 26.3 31.9 120.0 20.1 20.1 43.4 44.8 66.4 34.1 36.9 70.9 74.6 DPP3 ENSG00000254986 "Dipeptidyl peptidase 3" Q9NY33 11 66480013-66509657 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Rod photoreceptor cells: 72.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035780, HPA035781" Approved Supported Cytosol NA NA 3200000 "Cluster 27: Non-specific - Gene expression" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 46: Photoreceptor cells - Phototransduction" Cytosol "HPA035780: AB_2674778, HPA035781: AB_10669529" "unprognostic (5.74e-2)" "unprognostic (1.16e-3)" "unprognostic (2.62e-3)" "unprognostic (4.77e-2)" "unprognostic (1.99e-1)" "unprognostic (5.44e-3)" "unprognostic (1.67e-3)" "unprognostic (1.25e-3)" "unprognostic (1.73e-2)" "unprognostic (9.87e-2)" "unprognostic (1.02e-2)" "unprognostic (3.87e-1)" "unprognostic (5.85e-2)" "prognostic favorable (1.34e-4)" "unprognostic (1.81e-2)" "unprognostic (3.43e-1)" "unprognostic (5.66e-2)" 11.6 17.5 8.2 21.4 9.1 20.7 11.2 10.2 10.4 11.0 5.4 30.2 24.8 11.7 7.8 23.5 9.8 14.5 10.3 8.4 8.9 17.1 18.6 14.3 21.8 10.2 8.8 6.8 17.3 11.9 8.7 14.3 10.8 14.4 26.3 15.9 18.8 12.9 26.5 13.6 20.5 16.2 8.6 15.4 19.2 9.8 10.2 18.6 11.7 7.4 23.3 17.3 13.5 9.9 84.1 71.6 32.5 36.3 26.4 28.3 50.4 46.5 61.8 61.4 40.7 90.8 68.4 48.7 154.0 52.9 52.2 73.6 52.1 57.0 39.4 92.5 23.8 63.1 32.1 54.2 40.7 77.6 101.1 40.5 54.5 46.2 22.8 26.5 47.8 50.1 45.1 28.2 56.7 95.3 91.0 78.7 55.5 82.0 43.2 63.1 32.7 79.6 52.6 71.7 61.1 52.2 39.7 45.6 62.5 30.3 70.8 44.7 50.1 36.5 39.4 40.7 46.2 23.3 46.6 56.6 48.5 36.5 45.9 20.7 18.8 21.3 21.4 40.0 13.3 11.5 15.8 17.7 32.3 11.1 9.4 13.9 3.2 30.8 27.9 22.5 29.6 17.7 8.2 9.1 10.2 10.4 8.4 8.9 10.2 8.8 10.8 8.6 10.2 9.9 5.8 16.0 13.2 6.8 11.6 6.0 17.4 34.8 8.6 11.4 7.1 3.8 3.0 10.0 27.0 23.9 10.4 46.9 11.5 41.6 13.7 45.6 24.6 8.7 6.2 10.5 18.6 3.4 3.4 61.3 34.2 7.4 29.0 11.5 1.3 9.9 3.6 14.7 37.4 6.7 4.0 19.5 63.1 7.9 9.0 7.0 2.1 10.8 16.0 3.7 31.3 21.6 18.6 4.5 5.6 40.8 25.2 5.3 15.7 11.0 26.4 28.7 17.3 72.9 13.1 4.4 16.2 8.8 20.7 14.4 6.0 36.0 13.1 20.1 29.5 19.5 ECE1 ECE ENSG00000117298 "Endothelin converting enzyme 1" P42892 1 21217247-21345572 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant, Hirschsprung disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 164.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 29.8" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HUVEC TERT2: 673.8;TIME: 588.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001490, HPA013616" Enhanced NA NA 1300000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA001490: AB_1078718, HPA013616: AB_1847963" "unprognostic (7.90e-2)" "unprognostic (1.01e-1)" "unprognostic (1.48e-1)" "unprognostic (1.99e-2)" "unprognostic (1.49e-2)" "unprognostic (1.46e-1)" "unprognostic (5.24e-2)" "unprognostic (1.23e-1)" "unprognostic (6.20e-2)" "unprognostic (1.92e-3)" "unprognostic (1.04e-1)" "unprognostic (2.56e-1)" "unprognostic (7.70e-2)" "unprognostic (3.55e-2)" "unprognostic (9.10e-2)" "unprognostic (1.97e-2)" "unprognostic (1.97e-2)" 87.3 123.2 26.5 47.7 29.4 48.1 79.4 23.0 30.1 61.4 12.6 71.0 30.1 42.4 10.0 26.7 46.9 36.8 70.9 21.3 33.7 38.1 54.0 72.1 35.7 34.4 25.7 71.0 91.8 125.0 47.4 66.5 30.4 53.1 34.7 14.7 33.6 25.1 19.8 34.3 46.1 42.3 21.2 48.5 43.3 22.7 28.1 21.1 51.4 33.2 34.9 58.8 43.8 27.5 93.0 60.1 77.9 38.3 111.0 116.4 44.1 135.4 236.8 72.9 66.6 44.1 275.8 34.0 323.6 138.8 157.7 38.4 32.6 64.9 63.5 83.0 27.2 48.7 89.9 34.8 144.3 7.1 11.8 61.6 74.3 112.6 55.8 199.2 673.8 27.6 10.0 17.7 62.9 19.4 14.6 11.4 23.2 26.3 46.5 17.5 45.0 49.2 114.0 17.0 26.4 63.1 134.3 79.2 57.4 42.5 55.9 20.2 588.7 160.7 77.9 73.3 79.9 26.4 49.0 39.1 332.6 16.5 196.6 0.2 8.4 3.3 2.9 10.0 4.2 6.1 6.1 4.6 0.7 4.1 4.0 2.7 29.8 1.5 7.8 2.8 8.6 7.2 26.5 29.4 23.0 30.1 21.3 33.7 34.4 25.7 30.4 21.2 28.1 27.5 164.0 19.2 7.5 46.4 25.1 20.3 19.7 81.6 18.8 5.0 71.3 44.7 18.9 10.0 54.7 23.9 0.0 6.0 12.4 105.8 5.9 25.8 1.5 19.6 35.2 106.1 25.2 20.2 19.2 56.7 35.0 51.8 20.9 51.8 18.4 35.4 97.1 36.0 3.3 0.0 14.8 13.0 57.0 9.6 14.3 4.2 43.5 17.3 7.2 31.9 25.5 50.4 8.2 13.6 22.5 100.4 106.5 55.3 29.4 34.9 45.7 7.5 24.2 4.4 39.5 72.7 47.5 1.3 5.9 8.5 16.1 10.5 17.9 80.6 21.6 40.8 ECE2 "KIAA0604, MGC2408" ENSG00000145194 "Endothelin converting enzyme 2" P0DPD6 3 184276011-184293031 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Methyltransferase, Multifunctional enzyme, Protease, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 57.8;pancreas: 25.2;pituitary gland: 19.8" "Cell type enhanced" "Detected in many" "Early spermatids: 79.5;Extravillous trophoblasts: 51.1;Inhibitory neurons: 63.8;Late spermatids: 119.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 9 "REH: 10.3" NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 14: REH - Unknown function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (2.70e-2)" "unprognostic (1.44e-2)" "unprognostic (1.91e-2)" "prognostic unfavorable (8.41e-5)" "unprognostic (1.37e-2)" "unprognostic (1.09e-1)" "prognostic unfavorable (5.80e-4)" "unprognostic (1.47e-2)" "unprognostic (3.69e-1)" "unprognostic (2.65e-3)" "unprognostic (1.70e-2)" "unprognostic (5.95e-2)" "unprognostic (1.63e-9)" "unprognostic (3.66e-2)" "unprognostic (6.16e-2)" "unprognostic (2.19e-1)" "unprognostic (1.25e-2)" 0.0 9.3 24.8 0.2 24.6 0.0 0.0 22.2 28.0 0.0 8.5 1.3 0.0 0.0 0.5 0.0 0.1 0.0 1.9 16.1 57.8 0.0 0.0 0.0 0.0 29.0 52.5 0.0 25.2 4.2 19.8 0.0 36.1 0.6 0.2 5.5 0.3 0.3 0.0 0.0 0.3 0.2 21.5 0.0 0.7 0.2 54.7 0.0 0.0 0.0 0.0 0.0 0.2 15.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.3 0.0 0.0 0.0 0.0 1.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 24.8 24.6 22.2 28.0 16.1 57.8 29.0 52.5 36.1 21.5 54.7 15.2 0.0 0.0 0.0 5.2 3.8 38.2 18.2 15.5 20.5 5.5 0.0 0.0 2.2 10.0 7.2 0.0 2.1 21.6 2.7 6.7 0.0 0.0 79.5 0.0 0.0 3.3 12.2 6.3 5.1 0.0 51.1 3.5 9.2 0.0 0.0 0.0 3.3 35.3 17.2 26.9 63.8 12.8 16.2 4.4 5.7 119.8 3.1 4.1 8.8 1.0 4.6 2.4 5.2 30.2 1.1 0.0 5.9 2.2 12.5 35.1 13.5 0.0 2.2 2.3 6.6 2.6 5.1 43.4 9.7 16.9 39.1 21.5 2.3 0.0 13.8 16.2 ECEL1 "DINE, XCE" ENSG00000171551 "Endothelin converting enzyme like 1" O95672 2 232479827-232487834 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "brain: 106.9;ovary: 99.7;pituitary gland: 27.6" "Cell type enhanced" "Detected in some" "Bipolar cells: 33.5;Muller glia cells: 100.3;Peritubular cells: 21.1" "Cancer enhanced" "Detected in many" "endometrial cancer: 12.9" "Region enhanced" "Detected in many" "hypothalamus: 106.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "AN3-CA: 44.1;HeLa: 21.8" "Region enhanced" "Detected in many" "hypothalamus: 70.7" "Low region specificity" "Detected in many" "HPA067560, HPA069756, HPA077424" Approved Supported Approved "Nucleoplasm,Nuclear membrane,Nucleoli" NA NA "Cluster 35: Non-specific - Unknown function" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 5: Muller glia cells - Visual perception" Nucleoplasm "Nuclear membrane, Nucleoli" "HPA067560: , HPA069756: , HPA077424: " "unprognostic (1.21e-2)" "unprognostic (1.06e-2)" "unprognostic (4.39e-1)" "unprognostic (4.62e-3)" "unprognostic (2.80e-1)" "unprognostic (9.96e-4)" "unprognostic (7.56e-3)" "unprognostic (1.22e-1)" "unprognostic (9.89e-3)" "unprognostic (8.49e-2)" "unprognostic (1.54e-1)" "unprognostic (2.89e-1)" "unprognostic (1.24e-5)" "unprognostic (3.09e-2)" "unprognostic (3.68e-1)" "unprognostic (7.84e-2)" "unprognostic (5.45e-2)" 1.8 10.0 5.2 1.0 5.5 0.0 1.7 1.2 31.6 1.0 3.4 0.8 0.1 2.2 0.0 0.4 3.5 0.5 0.2 0.5 106.9 4.1 2.5 0.4 0.3 20.9 11.3 99.7 0.7 1.2 27.6 0.3 17.1 0.4 0.0 13.4 0.6 1.5 3.0 0.6 0.4 1.4 2.4 4.5 0.9 1.9 44.2 0.2 1.4 0.0 0.4 0.4 1.1 4.5 0.0 0.1 0.1 44.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.6 0.4 0.0 0.2 0.0 0.6 0.0 0.0 0.0 4.0 0.0 21.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 3.1 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 5.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.2 5.5 1.2 31.6 0.5 106.9 20.9 11.3 17.1 2.4 44.2 4.5 0.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 33.5 0.5 0.3 1.1 0.0 0.0 0.0 2.1 0.0 0.1 0.0 0.0 0.2 1.1 1.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 4.5 0.0 1.0 0.0 0.5 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 2.2 1.5 0.1 0.0 0.0 0.0 100.3 0.0 0.0 0.0 0.1 0.0 21.1 0.0 0.0 0.0 0.1 0.0 3.7 0.0 1.0 2.3 0.5 1.6 0.0 0.0 0.0 0.1 0.6 0.0 0.1 EEF1AKMT4-ECE2 ENSG00000284917 "EEF1AKMT4-ECE2 readthrough" P0DPD8 3 184249695-184293031 "Enzymes, Predicted membrane proteins" "Hydrolase, Metalloprotease, Methyltransferase, Multifunctional enzyme, Protease, Transferase" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA062215 Uncertain Nucleoplasm,Cytosol NA NA "Nucleoplasm, Cytosol" "HPA062215: AB_2684714" 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ENPEP "CD249, gp160" ENSG00000138792 "Glutamyl aminopeptidase" Q07075 4 110365733-110565285 "CD markers, Enzymes, Plasma proteins, Predicted membrane proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 163.6;kidney: 90.0" "Cell type enhanced" "Detected in many" "Proximal enterocytes: 663.2;Proximal tubular cells: 177.6;Sertoli cells: 157.8" "Cancer enriched" "Detected in many" 8 "renal cancer: 41.0" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 2.7;HEK 293: 7.5;MOLT-4: 1.8;SuSa: 5.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA005128 Enhanced NA NA 55000000 "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 45: Enterocytes - Digestion" "HPA005128: AB_1844795" "unprognostic (2.73e-3)" "unprognostic (2.84e-3)" "unprognostic (5.16e-3)" "unprognostic (3.48e-1)" "unprognostic (2.90e-1)" "unprognostic (8.74e-2)" "unprognostic (3.34e-2)" "unprognostic (1.03e-1)" "unprognostic (1.35e-2)" "unprognostic (1.22e-1)" "unprognostic (1.93e-1)" "unprognostic (9.47e-2)" "unprognostic (4.49e-3)" "unprognostic (3.43e-3)" "unprognostic (1.52e-2)" "unprognostic (8.46e-2)" "unprognostic (2.49e-3)" 11.6 2.2 0.4 1.5 0.5 0.1 4.8 0.4 2.5 1.6 1.8 1.2 36.6 12.9 4.1 1.7 2.3 4.4 4.3 0.6 0.5 90.0 29.0 4.6 0.8 0.9 0.8 1.2 1.3 45.2 1.2 15.5 0.7 1.8 0.8 0.0 1.1 1.2 2.3 0.7 163.6 10.6 0.5 9.2 1.2 0.5 0.4 4.4 5.0 8.9 0.3 2.6 1.6 0.8 0.0 0.2 0.0 0.0 0.1 0.1 2.7 0.4 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 7.5 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.0 1.8 0.3 0.3 0.1 0.0 0.1 0.0 0.3 0.0 0.3 0.1 0.1 0.0 1.3 0.0 5.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.7 1.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.5 0.4 2.5 0.6 0.5 0.9 0.8 0.7 0.5 0.4 0.8 10.7 0.0 2.0 1.6 1.1 1.7 0.1 0.0 0.0 0.0 0.2 0.1 3.9 0.0 0.3 11.0 0.0 37.0 0.0 1.5 17.6 0.0 0.5 3.1 40.7 2.2 1.8 0.0 7.3 0.0 3.5 15.4 0.0 2.3 0.0 0.0 1.4 31.4 2.7 0.0 2.9 28.4 2.0 1.0 1.9 0.2 0.6 1.1 0.0 1.0 0.0 0.0 1.0 0.0 0.8 0.0 31.6 0.4 0.1 0.2 663.2 177.6 1.7 0.0 157.8 0.8 54.1 0.0 0.2 0.1 1.0 58.6 1.9 0.5 42.1 0.1 ERAP1 "A-LAP, ARTS-1, ERAAP1, KIAA0525, PILS-AP" ENSG00000164307 "Endoplasmic reticulum aminopeptidase 1" Q9NZ08 5 96760810-96808100 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Adaptive immunity, Immunity" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 72.8;Inhibitory neurons: 79.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025095, HPA042317" Approved Approved "Nucleoplasm,Plasma membrane,Cytosol" "Secreted to blood" NA NA 30000000 "Cluster 34: Basophils - Unknown function" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Cytosol" "Plasma membrane" "CAB025095: , HPA042317: AB_2677946" "unprognostic (2.33e-3)" "unprognostic (3.45e-1)" "unprognostic (1.84e-3)" "unprognostic (1.34e-1)" "unprognostic (1.86e-1)" "unprognostic (4.38e-1)" "unprognostic (1.88e-3)" "unprognostic (5.37e-2)" "unprognostic (1.45e-1)" "unprognostic (7.94e-2)" "unprognostic (4.52e-2)" "unprognostic (3.23e-1)" "unprognostic (7.09e-2)" "unprognostic (1.36e-1)" "unprognostic (3.93e-2)" "unprognostic (1.19e-1)" "unprognostic (5.14e-2)" 51.5 15.8 3.7 37.0 4.3 27.9 25.5 3.1 5.6 21.8 2.3 37.9 63.4 22.0 14.4 13.2 25.5 23.7 17.1 3.4 5.2 16.4 32.9 31.2 38.2 8.4 5.7 20.7 13.7 19.1 8.2 47.0 7.0 18.6 43.7 12.4 19.3 22.0 20.9 36.5 55.1 21.7 5.0 30.8 33.7 9.1 6.6 63.7 17.5 19.6 36.8 27.3 11.7 6.8 25.9 14.1 21.3 20.0 114.7 111.5 61.4 18.3 59.6 44.0 76.2 17.6 91.1 75.3 37.6 36.0 61.8 25.7 17.8 38.1 27.3 139.8 7.5 24.7 10.0 13.9 130.9 12.0 44.1 46.8 16.2 50.6 15.5 64.3 61.1 48.8 12.9 74.7 26.7 11.6 113.2 12.4 10.6 3.1 10.4 82.4 28.8 38.4 32.8 39.0 7.8 5.5 29.6 19.8 28.6 14.6 17.1 57.0 48.8 37.4 12.6 6.2 31.1 26.9 53.9 57.8 40.2 40.2 22.5 28.8 15.2 18.0 22.6 12.3 20.2 14.8 19.2 19.1 10.5 18.3 22.3 18.1 15.8 23.1 20.6 16.7 13.9 13.7 3.7 4.3 3.1 5.6 3.4 5.2 8.4 5.7 7.0 5.0 6.6 6.8 11.1 9.6 16.3 34.0 15.3 25.0 14.2 19.2 8.6 13.6 6.6 3.9 10.6 10.0 16.9 9.2 2.1 9.6 21.1 24.4 0.0 12.4 27.0 12.7 15.0 16.3 10.3 14.1 72.8 15.5 11.9 18.4 16.3 19.8 15.2 13.9 16.8 28.0 17.6 3.3 79.3 23.9 4.1 29.9 16.1 7.3 9.9 22.9 7.2 24.4 32.5 9.0 20.6 32.6 70.1 12.3 14.1 16.1 32.3 13.5 47.3 6.9 23.1 7.6 0.0 10.3 22.6 1.4 1.8 9.8 11.1 9.2 21.8 5.7 27.3 14.9 ERAP2 "L-RAP, LRAP" ENSG00000164308 "Endoplasmic reticulum aminopeptidase 2" Q6P179 5 96875986-96919703 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Adaptive immunity, Immunity" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 49.9" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "CAPAN-2: 176.1;GAMG: 105.0;hTEC/SVTERT24-B: 83.2;MOLT-4: 98.8;TIME: 188.7" "Low region specificity" "Detected in all" "CAB025618, HPA034498, HPA064360" Enhanced Approved "Golgi apparatus" "Secreted to blood" NA NA 11000000 "Cluster 15: NK-cells - Transcription" "Cluster 3: T-cells - Adaptive immune response" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 63: NK-cells & T-cells - Immune response" "Golgi apparatus" "CAB025618: , HPA034498: AB_2674191, HPA064360: " "unprognostic (4.62e-2)" "unprognostic (1.60e-1)" "unprognostic (4.98e-2)" "unprognostic (1.56e-1)" "unprognostic (3.14e-1)" "unprognostic (8.71e-2)" "unprognostic (2.60e-2)" "unprognostic (1.17e-2)" "unprognostic (5.03e-2)" "unprognostic (1.40e-1)" "prognostic unfavorable (1.20e-4)" "unprognostic (1.01e-1)" "unprognostic (9.54e-3)" "unprognostic (6.59e-2)" "unprognostic (8.48e-2)" "unprognostic (4.65e-2)" "unprognostic (3.05e-1)" 7.8 7.1 3.0 31.5 3.0 7.5 11.9 2.3 4.3 12.2 3.0 16.2 32.6 8.4 17.5 10.5 7.0 11.0 7.5 2.9 2.5 11.3 14.5 18.1 46.4 4.3 3.3 8.5 2.9 3.7 3.6 11.0 3.5 10.3 6.2 2.3 6.6 7.0 8.9 10.1 21.5 3.4 2.7 36.7 19.0 1.7 3.8 49.9 5.6 9.9 29.7 14.7 6.8 3.5 2.1 2.4 1.7 0.9 1.9 3.8 0.6 8.1 13.8 7.3 12.3 7.9 176.1 12.2 35.1 11.5 105.0 2.9 0.9 65.4 5.8 4.3 7.9 0.6 3.0 8.5 2.7 43.2 19.2 25.3 12.8 83.2 0.6 1.2 4.9 27.4 0.2 25.8 20.8 1.4 98.8 22.5 0.2 0.0 3.7 45.7 16.2 29.3 55.2 15.4 3.5 0.2 1.1 0.9 16.5 0.4 6.5 1.7 188.7 3.9 1.1 10.0 24.6 26.2 23.2 4.2 50.8 5.8 0.9 23.0 12.1 15.4 24.8 27.5 31.3 28.5 34.6 30.6 19.8 17.7 37.4 28.9 4.2 45.4 28.5 6.9 34.6 27.6 3.0 3.0 2.3 4.3 2.9 2.5 4.3 3.3 3.5 2.7 3.8 3.5 46.7 32.1 20.0 11.8 62.6 5.7 11.2 24.4 12.0 1.5 3.1 5.8 4.4 8.6 15.9 44.1 0.0 11.5 35.6 48.1 0.0 5.3 0.3 7.0 10.6 34.1 1.8 15.8 2.5 25.5 17.0 23.4 17.3 7.4 7.0 33.4 31.4 16.3 12.3 0.0 2.1 23.3 8.2 29.4 14.2 0.7 10.5 33.0 7.2 21.5 19.4 6.5 20.6 7.1 4.9 22.1 27.6 7.9 56.0 4.3 52.4 6.2 15.7 2.8 0.0 12.2 12.2 0.9 0.8 10.0 3.0 6.7 54.2 9.3 34.2 10.5 ERMP1 "FLJ23309, FXNA, KIAA1815" ENSG00000099219 "Endoplasmic reticulum metallopeptidase 1" Q7Z2K6 9 5765076-5833117 "Enzymes, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 50.1" "Cell type enhanced" "Detected in many" "Collecting duct cells: 73.5;Granulosa cells: 53.4;Oligodendrocytes: 88.8;Urothelial cells: 66.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "NK-cell: 1.6" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "RPTEC TERT1: 76.8;RT4: 154.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA055582 Approved NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 15: RT4 - Unknown function" "Cluster 52: Non-specific - Transcription" "HPA055582: " "unprognostic (1.93e-2)" "unprognostic (3.40e-1)" "unprognostic (2.76e-2)" "unprognostic (5.93e-2)" "unprognostic (2.97e-1)" "unprognostic (8.59e-2)" "unprognostic (4.30e-3)" "unprognostic (2.81e-1)" "unprognostic (5.46e-2)" "unprognostic (4.83e-3)" "unprognostic (3.14e-2)" "unprognostic (2.88e-2)" "prognostic favorable (5.83e-10)" "unprognostic (1.41e-1)" "unprognostic (4.00e-1)" "unprognostic (5.77e-2)" "unprognostic (1.36e-1)" 3.9 7.9 4.2 3.7 10.4 2.0 6.3 10.9 3.7 10.8 14.4 11.3 4.4 5.6 2.6 14.9 6.4 11.3 10.0 2.9 6.1 24.9 4.6 6.3 3.5 10.1 10.3 4.5 3.9 50.1 1.5 7.8 8.8 6.0 11.4 2.2 19.1 4.1 7.6 9.3 6.5 3.8 6.5 3.1 13.3 4.7 8.9 4.6 26.6 9.9 6.4 17.1 4.8 13.1 45.1 43.1 1.8 5.2 22.6 20.7 22.6 5.1 11.1 2.3 1.9 10.4 27.2 10.7 19.2 8.4 25.9 32.2 9.6 29.4 3.3 55.6 7.6 56.2 20.0 20.4 4.8 16.0 21.3 10.5 12.9 2.1 13.3 28.6 30.1 4.6 6.9 9.9 2.8 20.7 0.6 6.2 6.6 28.0 8.4 1.7 5.3 14.1 76.8 154.6 9.9 3.3 7.1 52.2 8.1 24.5 33.7 20.5 18.0 1.5 5.0 3.4 16.1 8.9 13.6 5.5 6.7 13.0 4.1 0.2 0.1 0.3 0.4 0.1 0.6 0.0 0.2 0.1 0.0 0.0 0.1 0.1 0.0 1.6 0.0 0.1 0.1 0.1 4.2 10.4 10.9 3.7 2.9 6.1 10.1 10.3 8.8 6.5 8.9 13.1 3.4 6.4 1.1 24.8 2.2 2.9 18.3 13.3 2.8 4.0 11.1 5.8 13.7 12.8 22.8 73.5 10.4 6.8 5.2 32.1 0.0 4.6 22.3 11.4 10.9 6.3 11.4 6.3 21.0 3.0 7.1 4.6 13.7 13.8 8.9 53.4 2.9 6.1 5.7 3.3 32.8 8.9 10.2 1.6 2.2 41.8 3.1 4.5 1.8 24.4 2.1 3.0 8.2 22.1 88.8 3.5 22.5 4.9 4.1 7.0 9.2 3.3 16.6 2.9 6.6 5.8 4.3 8.8 4.6 17.5 4.5 4.1 5.9 39.8 15.7 66.9 FOLH1 "FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA" ENSG00000086205 "Folate hydrolase 1" Q04609 11 49145092-49208638 "Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Carboxypeptidase, Dipeptidase, Hydrolase, Metalloprotease, Multifunctional enzyme, Protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 266.4;prostate: 76.0" "Cell type enriched" "Detected in some" 8 "Oligodendrocytes: 367.6" "Cancer enriched" "Detected in many" 27 "prostate cancer: 142.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HAP1: 2.3;RPMI-8226: 1.7;SK-BR-3: 1.8;TIME: 1.3;WM-115: 2.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001451, HPA010593" Enhanced NA NA "Cluster 56: Intestine - Transmembrane transport" "Cluster 17: WM-115 - Nervous system development" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "CAB001451: AB_563979, HPA010593: AB_1079685" "unprognostic (1.33e-1)" "unprognostic (1.19e-1)" "unprognostic (1.24e-1)" "prognostic favorable (5.24e-5)" "unprognostic (2.55e-1)" "unprognostic (8.31e-2)" "prognostic favorable (4.25e-4)" "unprognostic (1.32e-1)" "unprognostic (2.09e-2)" "unprognostic (2.67e-3)" "unprognostic (2.13e-2)" "unprognostic (2.72e-1)" "prognostic unfavorable (1.30e-6)" "unprognostic (4.81e-2)" "unprognostic (7.27e-2)" "unprognostic (4.74e-3)" "unprognostic (4.04e-1)" 1.8 1.1 17.3 0.9 37.3 0.7 4.8 27.1 27.7 1.9 7.9 0.7 266.4 1.7 0.9 1.5 3.5 10.2 0.5 18.3 22.4 13.5 35.5 1.3 0.9 32.7 28.4 1.0 0.3 0.2 0.0 0.3 31.5 76.0 0.5 4.0 52.8 0.6 0.2 1.7 82.9 1.0 24.1 2.4 1.1 0.8 31.1 0.1 1.0 0.2 0.6 1.4 0.3 59.3 0.1 0.0 0.0 0.0 0.0 0.0 1.1 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.3 0.0 0.1 0.1 2.3 0.2 0.0 0.5 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.5 0.4 0.0 0.0 0.1 0.1 1.7 0.0 0.0 0.2 0.7 0.0 1.8 0.3 0.2 0.3 0.0 1.3 0.1 0.9 0.2 0.1 0.0 0.2 0.0 0.0 0.4 2.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 17.3 37.3 27.1 27.7 18.3 22.4 32.7 28.4 31.5 24.1 31.1 59.3 0.5 0.0 0.6 0.0 0.0 0.3 0.7 0.1 0.6 0.0 8.2 7.0 0.3 0.0 1.9 0.0 0.0 0.0 0.5 0.0 7.9 0.0 5.2 2.1 0.5 5.0 0.0 0.0 0.5 0.0 0.0 2.2 0.0 2.8 0.0 0.0 2.9 25.9 0.1 0.0 1.0 1.1 0.0 0.3 0.0 1.4 1.5 0.2 3.6 1.0 0.0 17.4 0.0 0.0 367.6 0.0 1.2 0.4 0.0 43.0 0.8 32.4 0.1 0.6 0.0 0.0 0.4 1.1 1.5 1.5 0.9 0.0 0.2 0.5 0.2 0.6 IDE ENSG00000119912 "Insulin degrading enzyme" P14735 10 92451684-92574096 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Host-virus interaction" "Allosteric enzyme, Host cell receptor for virus entry, Hydrolase, Metalloprotease, Protease, Receptor" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063478 Approved "Secreted in other tissues" NA NA 310000 "Cluster 27: Non-specific - Gene expression" "Cluster 31: Skin - Epidermis development" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA063478: AB_2685020" "unprognostic (1.70e-1)" "unprognostic (6.40e-2)" "prognostic favorable (3.69e-4)" "prognostic favorable (3.53e-4)" "unprognostic (2.54e-1)" "unprognostic (1.78e-1)" "unprognostic (2.51e-1)" "unprognostic (3.79e-1)" "unprognostic (8.88e-2)" "unprognostic (2.57e-1)" "unprognostic (6.58e-2)" "unprognostic (7.79e-2)" "unprognostic (6.81e-2)" "unprognostic (9.24e-3)" "unprognostic (6.13e-2)" "unprognostic (3.89e-2)" "unprognostic (3.91e-1)" 6.7 10.1 3.4 2.8 3.6 3.5 6.1 3.7 4.2 8.1 5.9 8.6 3.3 7.4 9.7 9.8 6.5 2.9 11.7 3.4 3.7 5.9 11.4 5.9 3.4 3.8 3.7 5.4 12.3 9.5 4.7 2.7 3.9 9.1 3.8 10.3 7.8 4.2 28.8 36.4 6.8 3.7 3.6 6.3 8.2 25.8 3.6 2.4 6.7 9.7 4.1 8.9 7.9 3.8 12.1 22.9 6.2 15.1 10.5 5.8 8.5 10.4 13.3 6.1 5.2 19.4 9.5 12.5 16.4 14.3 7.2 16.3 14.6 10.0 3.9 14.7 8.8 5.1 13.7 25.9 11.5 14.9 6.5 5.4 6.6 9.1 14.0 7.8 8.6 3.3 10.0 8.1 5.4 18.0 6.6 8.8 10.2 10.4 5.2 10.2 10.8 9.0 10.9 19.3 2.2 5.6 14.3 6.4 6.7 6.8 12.6 6.3 15.3 4.4 8.2 5.0 10.4 11.2 12.2 14.5 6.9 10.9 4.4 0.3 3.5 1.4 2.0 4.2 2.2 2.9 2.6 2.9 4.6 2.1 1.9 2.0 0.0 3.7 5.9 1.3 3.9 2.3 3.4 3.6 3.7 4.2 3.4 3.7 3.8 3.7 3.9 3.6 3.6 3.8 12.9 9.6 14.1 20.9 11.1 5.2 6.1 10.5 5.2 15.0 8.7 4.3 45.7 7.2 10.6 7.3 47.9 11.2 10.0 14.0 1.9 14.0 46.4 14.9 19.3 10.8 10.8 19.6 43.3 20.2 5.7 9.1 22.4 16.5 1.3 9.9 11.7 24.1 11.9 6.7 42.6 12.7 18.3 16.6 5.4 12.0 6.5 12.5 8.8 23.4 7.8 7.8 4.1 20.6 24.0 16.5 5.7 10.1 24.2 12.2 9.0 10.7 23.3 26.9 6.6 7.6 13.2 51.5 11.0 19.6 16.3 3.8 8.5 9.8 9.8 9.6 KEL "CD238, ECE3" ENSG00000197993 "Kell metallo-endopeptidase (Kell blood group)" P23276 7 142941114-142962363 "Blood group antigen proteins, Cancer-related genes, CD markers, Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Blood group antigen, Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "bone marrow: 56.3;testis: 32.3" "Cell type enhanced" "Detected in some" "Erythroid cells: 79.7;Oligodendrocytes: 30.1;Squamous epithelial cells: 16.8" "Cancer enhanced" "Detected in some" "testis cancer: 2.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 20 "HEL: 31.7;K-562: 26.2" "Not detected" "Not detected" "Not detected" "Not detected" HPA064442 Approved "Nucleoplasm,Golgi apparatus,Plasma membrane,Cytosol" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 1: K-562 - Erythropoiesis" "Cluster 6: Erythroid cells - Oxygen transport" "Golgi apparatus, Plasma membrane" "Nucleoplasm, Cytosol" "HPA064442: " "unprognostic (5.78e-3)" "unprognostic (1.08e-5)" "unprognostic (5.29e-3)" "unprognostic (4.85e-3)" "unprognostic (9.68e-2)" "unprognostic (1.96e-2)" "unprognostic (1.03e-1)" "unprognostic (1.54e-2)" "unprognostic (5.18e-2)" "unprognostic (1.08e-2)" "unprognostic (3.71e-2)" "unprognostic (3.57e-2)" "unprognostic (2.29e-3)" "unprognostic (9.24e-2)" "unprognostic (7.05e-2)" "unprognostic (3.32e-2)" "unprognostic (3.25e-3)" 0.2 0.0 1.8 0.8 2.7 56.3 0.3 1.7 2.2 0.9 1.4 0.1 0.0 0.2 0.0 0.8 0.5 0.0 0.3 2.0 1.5 0.6 0.3 0.5 10.6 2.5 2.2 0.2 0.2 0.0 0.2 0.4 2.4 0.3 0.0 0.1 0.6 0.1 0.2 0.1 0.9 0.0 1.9 4.9 0.2 32.3 2.4 1.3 0.3 0.0 6.7 0.1 0.4 2.8 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 31.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 26.2 0.0 0.0 0.1 0.5 0.1 0.6 0.0 0.0 0.1 0.0 0.2 0.0 1.4 0.0 0.2 0.0 0.0 0.3 0.4 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 2.7 1.7 2.2 2.0 1.5 2.5 2.2 2.4 1.9 2.4 2.8 0.2 0.0 0.0 0.3 0.0 0.0 1.3 0.2 4.0 0.0 0.3 0.1 0.4 0.0 1.4 3.7 0.0 0.1 0.1 0.0 1.9 0.3 2.4 0.2 0.1 0.1 0.0 79.7 3.0 0.0 0.2 0.4 0.0 0.1 0.0 0.1 0.0 0.0 0.9 0.0 0.5 0.0 0.0 0.0 0.0 0.8 0.6 0.4 0.0 0.0 0.0 0.0 0.0 0.0 30.1 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.0 3.1 0.0 1.4 0.2 16.8 0.0 0.1 0.0 0.0 0.0 0.9 LAP3 "LAP, LAPEP, PEPS" ENSG00000002549 "Leucine aminopeptidase 3" P28838 4 17577198-17607972 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Adipocytes: 230.6;Hofbauer cells: 262.1;Proximal tubular cells: 274.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029606, HPA029607" Enhanced Supported Nucleoplasm,Midbody,Cytosol Yes No 3500000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 64: Macrophages - Immune response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Cytosol "Nucleoplasm, Midbody" "HPA029606: AB_10599288, HPA029607: AB_10611381" "unprognostic (2.10e-2)" "unprognostic (1.01e-1)" "unprognostic (6.95e-3)" "unprognostic (1.46e-1)" "unprognostic (1.26e-1)" "unprognostic (2.87e-1)" "unprognostic (2.16e-1)" "unprognostic (1.55e-1)" "unprognostic (5.33e-2)" "unprognostic (1.44e-3)" "unprognostic (2.61e-3)" "unprognostic (1.17e-1)" "unprognostic (4.29e-3)" "unprognostic (1.73e-1)" "unprognostic (3.28e-2)" "unprognostic (3.06e-1)" "unprognostic (8.79e-2)" 92.8 52.6 33.0 131.4 34.8 59.2 60.3 39.0 42.9 30.7 31.4 60.3 78.3 34.4 25.4 44.6 45.4 67.3 65.0 31.8 36.3 106.3 190.4 100.6 150.4 46.3 37.7 24.0 30.9 61.0 22.1 70.9 42.2 36.7 62.0 20.0 67.7 31.0 68.1 40.3 61.3 76.2 45.6 94.1 55.3 43.8 41.9 56.8 46.4 63.8 94.3 82.8 25.3 42.9 51.7 44.4 41.6 39.4 80.5 97.9 0.4 79.6 89.1 282.3 340.3 81.4 96.1 202.0 51.7 61.6 167.9 31.3 157.7 56.3 106.7 77.7 45.2 112.1 47.3 107.6 94.1 102.3 69.2 100.0 35.3 92.7 48.6 32.3 99.7 52.2 110.6 139.9 67.6 55.6 91.9 139.5 87.1 96.3 83.9 139.8 39.8 102.7 73.5 59.6 61.4 50.2 72.9 44.4 161.1 57.3 37.9 39.1 65.2 71.3 48.5 76.1 140.6 127.7 208.8 172.7 96.3 167.2 70.8 43.1 200.6 44.7 33.7 210.0 31.0 32.7 31.2 36.3 204.6 23.5 26.7 28.3 28.1 54.0 158.1 116.6 60.2 135.8 33.0 34.8 39.0 42.9 31.8 36.3 46.3 37.7 42.2 45.6 41.9 42.9 230.6 28.9 49.6 10.7 34.4 22.0 26.1 60.1 21.6 8.1 53.5 41.7 48.9 18.6 44.1 27.6 2.1 35.9 68.3 44.2 117.4 68.6 100.5 67.3 45.7 129.7 16.3 31.7 6.4 109.2 54.7 42.0 29.6 40.7 64.1 29.4 71.0 95.5 262.1 6.7 9.6 35.6 42.7 92.1 50.5 31.7 23.0 141.9 42.7 18.7 195.0 103.8 28.8 9.5 21.2 53.3 31.8 35.0 71.2 26.9 52.4 274.0 92.5 15.4 32.9 31.3 57.8 95.7 13.7 32.5 22.9 55.7 42.4 80.7 45.6 27.1 LMLN "Gp63, LMNL1, Msp" ENSG00000185621 "Leishmanolysin like peptidase" Q96KR4 3 197960200-198043720 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Cell cycle, Cell division, Mitosis" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 39.7;Endometrial ciliated cells: 35.2;Respiratory ciliated cells: 37.5;Spermatocytes: 33.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016481, HPA028844" Uncertain Supported "Focal adhesion sites,Cytosol" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 16: U-266 - Nucleosome" "Cluster 49: Ciliated cells - Cilium organization" Cytosol "Focal adhesion sites" "HPA016481: AB_1852955, HPA028844: AB_10602347" "unprognostic (2.54e-1)" "unprognostic (3.15e-1)" "unprognostic (7.63e-2)" "prognostic favorable (6.77e-4)" "unprognostic (1.14e-2)" "unprognostic (1.19e-1)" "unprognostic (1.30e-1)" "unprognostic (4.07e-2)" "unprognostic (1.94e-1)" "unprognostic (2.31e-1)" "unprognostic (6.36e-2)" "unprognostic (2.98e-1)" "unprognostic (4.82e-3)" "unprognostic (8.78e-2)" "unprognostic (7.65e-2)" "unprognostic (1.01e-1)" "unprognostic (1.63e-1)" 2.1 2.6 2.7 1.2 3.4 1.2 2.2 3.6 4.7 3.1 4.7 2.1 1.0 2.2 10.7 2.2 4.9 2.6 3.3 2.7 3.7 3.4 2.2 2.5 1.3 4.2 3.3 3.3 3.8 3.8 6.5 2.0 4.5 2.3 2.0 9.7 2.4 3.4 2.4 3.4 1.4 2.0 3.0 1.5 2.0 10.1 4.0 1.1 4.1 2.0 1.2 1.9 2.3 3.2 7.7 2.8 3.3 4.0 6.4 9.0 2.9 3.9 3.6 6.9 5.6 2.8 2.7 2.4 17.7 2.8 14.9 2.8 3.1 3.1 10.0 0.3 2.3 1.4 2.3 2.1 4.0 4.4 2.0 4.3 6.8 8.6 5.5 4.0 3.0 6.0 7.5 4.5 6.7 5.7 2.6 3.8 3.8 5.5 6.7 3.0 0.8 2.6 7.1 2.0 5.4 1.5 5.4 4.8 3.9 3.7 12.5 3.2 6.6 8.4 1.3 10.3 6.7 8.0 16.7 0.7 12.0 7.4 7.8 0.0 0.1 0.1 0.2 0.4 0.3 0.4 0.1 0.3 0.4 0.2 0.4 0.5 0.1 0.3 0.2 0.1 0.0 0.2 2.7 3.4 3.6 4.7 2.7 3.7 4.2 3.3 4.5 3.0 4.0 3.2 4.4 16.0 14.8 24.5 1.7 2.0 1.5 2.6 4.0 8.1 6.4 4.8 11.6 2.8 9.2 9.2 16.7 3.6 1.2 2.2 0.0 3.5 39.7 35.2 11.5 3.2 4.8 0.8 25.3 2.7 2.2 5.5 1.5 11.5 2.5 6.3 4.2 3.1 5.0 8.4 23.1 3.6 0.0 1.9 2.3 21.9 4.7 2.3 3.6 9.4 1.1 5.9 1.0 6.6 13.7 2.1 1.0 5.7 2.1 1.8 0.7 3.5 37.5 17.7 0.0 6.6 3.8 33.2 23.6 3.7 1.7 2.9 2.1 10.6 2.8 1.1 LMLN2 ENSG00000283654 "Leishmanolysin like peptidase 2" A0A1B0GTW7 14 23099062-23104989 "Enzymes, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at transcript level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Evidence at transcript level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 9 "HSkMC: 2.5" "Not detected" "Not detected" NA NA "Cluster 34: Mesenchymal cell lines - ECM organization" 0.1 0.1 0.1 0.1 0.4 0.2 0.1 0.2 0.3 0.0 0.5 0.1 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.3 0.3 0.1 0.0 0.0 0.3 0.0 0.3 0.1 0.1 0.1 0.0 0.0 0.0 0.2 0.1 0.0 0.1 0.1 0.0 0.2 0.3 0.0 0.2 0.0 0.2 0.0 0.0 0.4 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 2.5 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.2 0.3 0.1 0.2 0.3 0.3 0.3 0.1 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 LNPEP "CAP, IRAP, P-LAP, PLAP" ENSG00000113441 "Leucyl and cystinyl aminopeptidase" Q9UIQ6 5 96935394-97037513 "Enzymes, Predicted membrane proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "NK-cells: 257.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043642 Approved "Intracellular and membrane" NA NA 9800000 "Cluster 27: Non-specific - Gene expression" "Cluster 34: Non-specific - Transcription" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 63: NK-cells & T-cells - Immune response" "HPA043642: AB_10964137" "unprognostic (1.52e-1)" "unprognostic (5.39e-2)" "unprognostic (7.78e-2)" "unprognostic (1.53e-2)" "unprognostic (6.38e-2)" "unprognostic (6.59e-3)" "unprognostic (6.83e-2)" "unprognostic (2.11e-1)" "unprognostic (1.11e-1)" "unprognostic (3.54e-3)" "unprognostic (6.24e-2)" "unprognostic (2.08e-1)" "unprognostic (3.28e-1)" "unprognostic (4.13e-3)" "unprognostic (1.46e-1)" "unprognostic (1.69e-1)" "unprognostic (1.17e-1)" 11.4 4.4 8.4 12.2 10.6 16.2 8.2 17.9 8.6 6.8 4.0 8.1 5.2 6.5 5.1 9.0 5.7 5.1 12.0 8.5 10.0 8.3 4.3 7.7 19.4 10.0 9.4 8.8 4.9 15.3 5.8 9.1 10.7 8.8 7.9 9.4 6.0 8.5 11.2 16.4 8.2 7.7 8.6 12.5 7.9 4.1 9.2 17.8 8.4 12.7 18.7 7.0 7.0 10.3 10.7 11.9 5.4 5.6 32.5 15.4 6.2 10.5 13.8 12.0 18.1 9.9 16.4 52.2 19.1 14.1 33.7 13.4 6.8 20.1 12.5 18.2 3.8 12.9 8.2 7.3 8.4 15.5 16.9 12.0 12.5 17.5 13.3 13.6 12.8 11.6 5.6 32.7 13.9 9.6 18.1 10.9 1.1 3.4 6.2 12.7 19.8 7.9 44.9 21.2 10.2 2.7 12.8 11.4 6.4 5.2 34.1 20.2 26.6 17.6 9.6 13.9 16.3 7.3 17.4 45.6 16.1 14.5 8.2 4.3 2.6 3.6 5.9 4.2 5.0 2.3 4.4 4.6 2.8 3.1 4.2 4.7 3.1 9.0 11.2 2.6 4.2 3.6 8.4 10.6 17.9 8.6 8.5 10.0 10.0 9.4 10.7 8.6 9.2 10.3 43.4 35.3 41.3 52.2 91.0 59.4 21.3 28.4 37.5 58.9 24.9 18.8 80.8 22.8 27.2 36.8 125.1 12.3 108.4 20.7 5.9 15.4 3.6 21.4 28.9 33.6 25.7 38.9 47.5 14.4 24.3 36.6 30.1 28.9 25.9 29.3 30.7 16.7 16.2 23.5 50.9 29.6 22.4 49.3 35.9 5.3 32.9 52.0 21.4 45.9 59.7 33.6 257.5 49.3 73.9 21.5 17.5 46.6 44.9 27.4 16.6 10.7 25.8 38.4 26.3 46.8 36.6 29.4 27.5 44.4 47.2 27.4 97.3 31.1 25.6 23.2 LTA4H ENSG00000111144 "Leukotriene A4 hydrolase" P09960 12 96000753-96043520 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Leukotriene biosynthesis, Lipid metabolism" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hofbauer cells: 207.2;Kupffer cells: 255.8;monocytes: 245.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008399, CAB015221, HPA017017" Supported Approved Nucleoplasm,Cytosol NA NA 86000000 "Cluster 7: Monocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "Nucleoplasm, Cytosol" "CAB015221: , HPA008399: AB_1852816, HPA017017: AB_1852818" "prognostic favorable (9.79e-4)" "unprognostic (6.62e-2)" "unprognostic (6.04e-2)" "unprognostic (1.87e-1)" "unprognostic (1.38e-2)" "unprognostic (2.59e-2)" "unprognostic (4.25e-3)" "prognostic favorable (8.96e-4)" "unprognostic (1.72e-1)" "unprognostic (1.75e-2)" "unprognostic (3.38e-2)" "unprognostic (1.34e-1)" "unprognostic (1.73e-1)" "unprognostic (1.74e-1)" "unprognostic (1.04e-1)" "unprognostic (3.50e-2)" "unprognostic (1.34e-1)" 40.2 66.9 24.6 64.5 25.5 180.4 53.6 29.4 30.6 55.6 33.8 48.2 78.1 51.1 38.4 110.1 61.7 40.3 35.5 25.0 27.8 58.1 43.9 190.8 64.1 26.3 25.4 110.5 54.9 53.3 37.4 27.4 26.0 41.1 49.6 36.9 41.2 40.9 45.0 67.8 60.5 58.3 25.7 57.8 46.6 19.9 28.1 49.2 49.4 45.0 96.4 51.9 52.7 33.0 85.2 90.4 123.5 73.4 104.2 115.1 53.8 33.7 101.8 67.5 78.1 66.6 72.0 190.0 42.0 51.9 52.8 108.3 103.4 140.1 92.3 63.3 97.0 68.5 54.3 81.8 61.8 35.7 39.4 110.1 118.4 91.9 114.5 305.3 134.9 101.1 42.9 32.5 98.7 59.2 96.7 115.0 145.8 100.7 115.5 88.9 90.5 109.7 125.7 107.7 63.9 75.5 64.2 80.4 78.3 95.1 98.7 44.7 49.0 28.3 47.6 40.2 38.2 42.8 79.4 85.4 19.1 66.2 22.3 4.4 662.9 17.7 33.4 699.2 63.4 126.1 46.6 43.4 282.3 157.5 65.0 50.5 46.0 120.4 638.8 70.4 51.2 591.5 24.6 25.5 29.4 30.6 25.0 27.8 26.3 25.4 26.0 25.7 28.1 33.0 32.8 38.5 135.0 15.3 82.8 51.9 64.8 96.6 52.3 21.4 41.8 41.1 25.3 25.8 110.2 38.6 33.3 29.3 47.9 17.6 74.3 42.9 74.3 18.4 20.8 38.2 21.6 50.5 21.3 28.0 28.2 29.7 38.2 27.3 7.6 31.5 57.8 21.7 207.2 11.8 18.5 40.4 40.7 255.8 76.6 16.4 36.7 183.3 21.4 10.3 245.5 35.5 26.8 19.6 17.5 20.8 27.1 41.0 40.1 35.4 73.2 69.3 45.0 55.6 6.6 26.7 35.4 46.9 11.6 108.0 74.9 20.8 39.1 32.9 70.4 49.7 LVRN "APQ, AQPEP, FLJ90650, TAQPEP" ENSG00000172901 Laeverin Q6Q4G3 5 115962454-116027619 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 8 "adipose tissue: 11.1;placenta: 21.8" "Group enriched" "Detected in some" 4 "Early spermatids: 29.3;Extravillous trophoblasts: 33.1;Late spermatids: 68.1" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in single" 8 "spinal cord: 2.5" HPA053254 Enhanced "Intracellular and membrane" NA NA "Cluster 28: Placenta - Pregnancy" "Cluster 50: Fibroblasts - ECM organization" "HPA053254: AB_2682092" "unprognostic (1.47e-1)" "unprognostic (3.38e-3)" "unprognostic (5.81e-2)" "unprognostic (2.97e-3)" "unprognostic (5.38e-2)" "unprognostic (1.32e-1)" "unprognostic (2.59e-3)" "unprognostic (1.88e-2)" "unprognostic (2.23e-1)" "unprognostic (2.23e-2)" "unprognostic (3.83e-3)" "unprognostic (1.22e-1)" "unprognostic (1.67e-7)" "unprognostic (1.05e-2)" "unprognostic (5.94e-2)" "unprognostic (6.53e-2)" "unprognostic (3.31e-2)" 11.1 0.0 0.0 0.0 0.0 0.1 2.0 0.0 0.1 0.2 0.0 0.5 0.1 0.0 0.0 0.3 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 21.8 0.0 0.0 0.4 0.0 0.2 0.1 0.3 0.4 0.8 0.3 0.0 0.0 0.1 0.1 0.0 0.1 0.1 1.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.9 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.5 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.1 29.3 0.0 0.1 0.1 0.0 0.0 2.1 0.0 33.1 7.9 0.5 0.0 0.0 0.0 0.0 0.0 1.2 0.0 1.8 0.0 0.0 0.0 0.0 68.1 4.7 0.3 0.0 1.9 0.0 0.0 0.0 3.0 1.5 0.0 0.0 0.4 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.0 0.4 0.3 0.3 0.1 0.0 10.7 0.0 1.0 0.0 0.1 MBTPS2 "KFSD, S2P" ENSG00000012174 "Membrane bound transcription factor peptidase, site 2" O43462 X 21839617-21885423 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins" "Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Hydrolase, Metalloprotease, Protease" "Disease variant, Ichthyosis, Osteogenesis imperfecta, Palmoplantar keratoderma" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005494, CAB009486" Approved Approved Nucleoplasm,Mitochondria,Cytosol NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 85: Liver - Metabolism" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Mitochondria, Cytosol" "CAB009486: AB_2140370, HPA005494: AB_1079329" "unprognostic (7.97e-3)" "unprognostic (9.12e-2)" "unprognostic (5.38e-2)" "unprognostic (1.18e-2)" "unprognostic (2.65e-1)" "unprognostic (1.50e-1)" "unprognostic (1.85e-1)" "unprognostic (7.22e-2)" "unprognostic (3.32e-1)" "unprognostic (9.30e-2)" "unprognostic (1.99e-1)" "unprognostic (1.77e-1)" "unprognostic (8.38e-2)" "unprognostic (7.76e-2)" "unprognostic (1.07e-1)" "unprognostic (3.61e-1)" "unprognostic (3.05e-2)" 8.6 10.6 3.5 5.2 4.0 1.7 8.8 7.8 4.9 7.5 4.5 5.1 5.2 9.7 6.0 5.8 7.3 6.7 7.7 3.7 4.1 9.4 18.7 5.5 5.0 4.4 4.1 12.5 7.3 11.0 3.8 11.6 4.9 10.5 6.0 8.8 6.6 8.5 7.1 3.7 4.2 10.1 4.1 4.8 5.8 4.1 4.2 4.9 9.0 9.1 4.7 6.8 4.0 6.1 16.9 34.5 16.1 16.5 19.8 24.4 7.7 24.4 24.7 22.7 19.7 13.8 22.5 14.6 12.4 26.2 44.4 15.4 22.4 14.0 27.9 10.9 17.8 7.2 19.7 11.4 27.1 15.6 6.8 23.2 14.8 34.3 25.1 23.0 17.8 8.4 20.3 15.8 26.1 10.5 6.4 8.1 15.0 8.8 25.1 7.9 29.8 16.4 15.7 8.4 3.9 32.8 34.3 21.5 30.5 21.3 28.9 13.2 21.2 28.4 6.6 41.9 18.5 19.1 26.0 6.9 31.6 6.4 28.0 0.0 2.2 0.8 2.2 2.5 2.0 1.9 1.6 2.0 3.6 1.7 2.2 2.6 0.2 2.6 2.6 2.4 3.2 1.7 3.5 4.0 7.8 4.9 3.7 4.1 4.4 4.1 4.9 4.1 4.2 6.1 5.5 9.6 11.5 16.6 5.8 5.5 4.8 7.0 8.0 11.8 7.5 5.1 13.3 8.6 7.1 7.3 18.8 7.0 2.2 3.8 0.0 5.9 0.3 4.0 11.5 5.6 2.4 2.1 16.8 8.9 7.1 10.8 6.1 3.7 10.8 14.5 7.5 18.7 9.4 30.3 25.0 3.4 12.2 9.2 4.0 1.9 10.5 4.8 10.6 11.2 5.0 7.3 3.1 21.6 22.2 6.1 2.4 13.2 9.1 7.4 4.9 7.2 10.7 14.5 0.0 8.6 8.3 2.7 1.5 6.5 2.7 4.8 5.1 12.3 4.3 4.9 METAP1 "KIAA0094, MAP1A, MetAP1A" ENSG00000164024 "Methionyl aminopeptidase 1" P53582 4 98995659-99062809 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in all" 4 "Late spermatids: 1627.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025485, HPA037997, HPA037998" Approved Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA 8900 "Cluster 44: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" Cytosol "Nucleoplasm, Plasma membrane" "CAB025485: , HPA037997: AB_2675777, HPA037998: AB_2675778" "unprognostic (1.79e-1)" "unprognostic (3.39e-1)" "prognostic favorable (7.22e-4)" "unprognostic (1.58e-2)" "unprognostic (6.53e-2)" "unprognostic (2.15e-1)" "prognostic unfavorable (3.08e-5)" "unprognostic (1.09e-1)" "unprognostic (1.51e-3)" "unprognostic (2.05e-1)" "prognostic unfavorable (2.28e-5)" "unprognostic (2.00e-1)" "prognostic favorable (1.72e-4)" "unprognostic (5.50e-2)" "unprognostic (8.51e-2)" "unprognostic (1.15e-3)" "prognostic favorable (9.31e-4)" 14.8 9.5 10.2 20.5 11.6 25.1 28.7 10.5 13.8 24.0 8.8 31.8 24.1 25.7 43.7 52.3 24.3 15.1 41.1 11.2 10.0 24.7 24.0 15.6 24.9 9.5 10.1 14.0 19.5 14.0 11.6 16.9 9.4 29.2 33.5 11.3 23.1 29.7 33.8 28.7 23.4 25.7 9.2 17.6 19.6 51.6 10.6 41.9 18.8 28.7 31.2 34.5 30.8 10.4 57.6 55.9 47.7 51.7 37.2 59.1 52.9 80.3 51.5 67.1 63.7 62.9 83.3 84.1 31.3 65.5 40.3 56.1 84.8 80.5 92.9 59.2 39.9 75.6 37.8 68.2 40.2 103.6 60.8 42.8 57.5 57.0 60.4 52.4 56.3 46.9 60.0 49.7 73.2 44.0 90.9 49.3 58.7 97.7 44.3 58.9 74.5 45.4 109.2 73.6 64.7 38.5 27.0 82.5 32.8 53.1 31.6 39.3 46.1 53.9 68.0 49.9 70.9 35.5 53.5 66.2 46.5 51.9 54.8 19.1 11.6 5.7 17.7 14.6 23.1 16.0 18.0 17.6 14.9 11.4 17.4 15.8 2.9 17.7 14.7 7.2 17.7 14.1 10.2 11.6 10.5 13.8 11.2 10.0 9.5 10.1 9.4 9.2 10.6 10.4 16.1 41.7 14.6 20.2 19.8 42.4 47.5 26.2 51.2 5.2 21.0 24.9 57.0 17.2 19.5 14.7 2.1 24.4 17.4 36.7 13.7 28.4 330.3 45.4 30.0 17.3 7.8 24.2 22.6 29.4 70.5 15.3 22.4 60.9 3.8 16.9 12.8 21.4 17.2 3.3 15.0 23.3 24.4 20.2 16.2 1627.3 19.3 17.4 16.0 14.0 13.9 10.6 25.7 17.6 22.3 28.0 30.8 22.6 17.8 34.4 25.3 31.6 17.2 3.7 26.3 11.5 21.7 15.7 41.6 54.3 38.8 7.7 23.6 18.1 36.2 46.9 METAP1D "MAP1D, Metap1l" ENSG00000172878 "Methionyl aminopeptidase type 1D, mitochondrial" Q6UB28 2 171999943-172082430 "Enzymes, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Inhibitory neurons: 39.5;Oligodendrocyte precursor cells: 35.7;Oligodendrocytes: 35.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030298, HPA030299, HPA077742" Uncertain Uncertain Vesicles NA NA "Cluster 32: T-cells - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 1: K-562 - Erythropoiesis" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles "HPA030298: AB_2673419, HPA030299: AB_10602421, HPA077742: " "unprognostic (5.31e-2)" "unprognostic (1.07e-1)" "unprognostic (1.88e-1)" "unprognostic (5.83e-2)" "unprognostic (2.54e-2)" "unprognostic (7.90e-3)" "unprognostic (1.92e-3)" "unprognostic (1.07e-2)" "unprognostic (4.55e-1)" "unprognostic (7.07e-2)" "unprognostic (2.64e-2)" "unprognostic (8.19e-2)" "unprognostic (2.53e-3)" "unprognostic (3.44e-3)" "unprognostic (3.06e-2)" "unprognostic (5.48e-3)" "unprognostic (2.92e-2)" 4.4 4.9 4.3 2.4 4.5 3.5 3.9 3.7 5.0 5.4 3.7 4.6 2.3 4.5 2.8 3.4 6.7 2.0 4.8 4.1 5.1 4.5 6.0 2.3 2.8 4.1 4.1 11.9 8.1 2.2 4.3 1.8 4.6 5.6 3.2 2.5 4.1 3.7 7.8 3.4 4.1 2.8 3.6 5.8 4.6 2.8 4.3 1.2 3.6 5.6 2.0 4.2 3.8 5.0 3.6 2.8 4.1 13.5 5.9 7.7 8.3 4.1 4.1 6.4 4.1 6.4 4.7 1.8 7.2 4.3 6.6 6.4 9.1 7.2 6.5 6.3 10.6 10.2 7.8 8.6 6.2 6.1 2.6 5.8 10.9 6.4 10.2 5.5 3.6 6.9 14.8 5.1 4.9 4.4 3.5 8.2 7.4 10.4 3.4 7.7 3.5 3.3 4.5 5.0 8.4 3.2 2.9 5.8 10.2 3.6 6.7 8.1 4.4 8.1 6.4 5.0 4.0 6.3 6.1 4.0 5.8 11.9 7.9 0.0 0.0 0.0 0.4 0.4 0.2 0.3 0.5 0.2 0.1 0.7 0.5 1.1 0.0 0.4 0.0 0.0 0.4 0.2 4.3 4.5 3.7 5.0 4.1 5.1 4.1 4.1 4.6 3.6 4.3 5.0 6.1 0.0 4.6 23.8 15.4 5.6 10.3 7.5 22.8 5.8 9.2 8.9 4.5 7.2 3.5 3.7 2.1 4.1 2.7 1.3 7.9 2.5 1.2 2.7 14.7 5.4 0.0 16.8 19.6 3.5 4.7 10.9 8.2 2.5 4.5 17.9 6.4 6.4 3.9 5.0 39.5 2.9 2.0 2.5 2.2 2.3 33.5 2.2 5.4 14.0 1.0 3.7 9.2 35.7 35.5 1.4 1.3 26.4 9.9 4.3 0.6 5.7 2.0 6.1 13.1 18.1 9.5 9.8 12.2 11.6 5.7 1.9 7.5 14.5 5.7 5.1 METAP2 "MAP2, MNPEP, p67" ENSG00000111142 "Methionyl aminopeptidase 2" P50579 12 95473520-95515839 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013025, HPA019095" Enhanced Supported "Plasma membrane,Cytosol" NA NA 70000 "Cluster 6: Non-specific - Transcription" "Cluster 52: Non-specific - Ribosome" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 10: Non-specific - Unknown function" "Plasma membrane, Cytosol" "CAB013025: AB_2533993, HPA019095: AB_1853823" "unprognostic (1.91e-1)" "unprognostic (1.02e-1)" "unprognostic (5.92e-2)" "unprognostic (2.44e-1)" "unprognostic (3.27e-2)" "unprognostic (2.57e-2)" "prognostic unfavorable (4.51e-6)" "unprognostic (1.25e-1)" "unprognostic (2.28e-2)" "unprognostic (1.40e-2)" "unprognostic (8.53e-2)" "unprognostic (1.66e-1)" "unprognostic (1.49e-1)" "unprognostic (2.51e-1)" "unprognostic (1.07e-1)" "unprognostic (2.95e-2)" "unprognostic (1.03e-1)" 52.5 58.0 41.1 51.6 44.5 102.2 55.0 45.0 53.2 46.0 39.7 50.7 36.7 54.2 52.6 54.7 42.6 47.0 65.9 40.2 49.9 55.6 84.5 49.0 78.0 46.5 43.8 60.5 52.7 52.3 36.6 51.3 48.8 43.3 50.9 30.8 40.6 101.0 119.5 58.3 37.7 54.9 42.4 40.3 37.4 61.8 44.7 69.1 51.8 78.7 125.0 62.2 41.5 50.2 192.3 157.8 163.7 129.6 98.4 156.4 125.9 186.0 127.6 177.7 125.7 228.0 88.6 542.1 113.5 133.4 101.9 120.5 187.4 142.4 203.8 131.2 161.2 244.9 113.7 165.6 104.5 313.5 117.1 137.5 148.1 164.9 164.0 210.7 192.9 184.2 321.8 60.5 135.3 125.8 230.3 213.0 204.5 109.4 233.4 179.6 141.5 178.5 123.5 198.3 127.0 165.3 166.0 132.7 169.0 140.6 159.4 146.5 165.1 100.7 98.5 115.0 195.7 87.7 246.8 585.1 58.1 173.7 129.9 77.5 70.5 32.0 60.0 52.2 74.3 114.2 66.8 67.8 66.0 101.8 79.2 74.1 3.4 72.8 65.6 85.3 71.6 46.4 41.1 44.5 45.0 53.2 40.2 49.9 46.5 43.8 48.8 42.4 44.7 50.2 87.0 282.0 238.9 22.9 101.3 233.2 130.2 141.3 97.3 70.6 119.7 95.9 143.6 100.1 133.3 290.6 66.7 146.2 87.7 96.8 164.4 115.2 189.5 114.9 260.0 110.2 91.7 278.4 35.1 145.8 161.5 112.2 53.0 153.7 122.9 140.5 112.1 314.6 98.1 75.7 49.5 119.7 73.2 141.0 89.8 123.3 100.3 83.8 92.5 20.6 103.5 72.6 81.4 26.2 41.4 130.1 105.8 106.8 87.0 108.1 93.4 186.6 92.4 83.8 98.6 137.4 133.4 378.4 207.6 95.2 215.0 172.0 80.7 101.4 144.8 110.5 MIPEP MIP ENSG00000027001 "Mitochondrial intermediate peptidase" Q99797 13 23730189-23889400 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 108.0;Oligodendrocytes: 62.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "OE19: 64.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030676, HPA031669, HPA031670" Approved Enhanced Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 8: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 54: Cardiomyocytes - Muscle contraction" Mitochondria "HPA030676: AB_10598907, HPA031669: AB_10600986, HPA031670: AB_10602198" "unprognostic (2.05e-1)" "unprognostic (3.17e-2)" "unprognostic (3.75e-3)" "unprognostic (3.72e-2)" "unprognostic (1.24e-1)" "unprognostic (1.23e-1)" "unprognostic (2.41e-1)" "unprognostic (2.21e-1)" "unprognostic (4.69e-2)" "unprognostic (1.12e-1)" "unprognostic (7.54e-2)" "unprognostic (4.76e-1)" "prognostic favorable (7.66e-12)" "unprognostic (1.62e-2)" "unprognostic (4.95e-2)" "unprognostic (2.79e-1)" "unprognostic (6.90e-3)" 6.3 9.6 3.7 6.2 4.3 5.3 11.1 3.2 5.0 7.5 13.4 12.9 8.8 7.2 12.4 11.5 17.3 7.7 18.4 14.4 4.0 25.4 12.0 7.1 5.1 4.0 5.0 5.4 8.2 14.6 5.4 4.7 4.6 10.9 13.1 6.1 9.7 8.7 13.9 21.4 7.6 7.8 4.0 4.3 8.6 9.8 3.7 6.0 11.1 16.9 7.8 7.7 6.4 4.9 14.6 16.1 7.8 18.4 17.4 23.4 16.6 10.3 16.0 15.1 12.7 21.7 28.1 17.0 10.2 8.4 13.3 35.8 18.1 21.6 18.8 9.9 11.5 7.4 7.0 18.8 14.3 17.5 3.9 11.6 26.4 15.7 13.9 12.7 19.2 12.7 14.5 2.7 24.0 10.8 12.6 9.8 10.8 64.8 16.1 13.8 21.0 14.8 33.7 9.6 18.2 6.1 11.0 17.8 21.8 9.8 18.3 9.7 10.7 9.2 7.6 15.3 11.2 2.6 4.0 9.1 15.9 8.8 11.7 0.0 3.0 1.3 7.4 3.7 9.3 8.7 7.1 6.8 6.5 7.2 6.7 6.7 0.0 10.3 12.0 5.5 5.2 4.0 3.7 4.3 3.2 5.0 14.4 4.0 4.0 5.0 4.6 4.0 3.7 4.9 2.5 16.0 8.6 18.9 5.9 39.9 7.7 13.8 6.2 3.6 6.2 5.8 108.0 11.5 12.6 9.2 6.2 9.8 2.4 8.2 29.4 23.4 8.2 26.0 8.5 5.4 6.0 4.6 43.8 10.6 9.3 8.0 7.1 8.5 2.5 4.2 3.6 5.9 9.7 15.2 47.5 7.1 14.2 3.5 5.0 7.4 6.8 4.3 5.4 12.2 3.4 5.5 5.2 18.1 62.8 8.6 7.0 8.6 4.9 7.5 6.6 25.6 46.3 11.4 0.0 7.3 5.7 9.7 19.0 10.1 42.3 5.1 4.0 8.9 13.6 5.6 MME "CALLA, CD10, NEP" ENSG00000196549 "Membrane metalloendopeptidase" P08473 3 155024124-155183704 "Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, Charcot-Marie-Tooth disease, Disease variant, FDA approved drug targets, Neurodegeneration, Neuropathy, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 333.5;kidney: 302.5" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 273.3;Proximal enterocytes: 372.4;Proximal tubular cells: 125.7;Syncytiotrophoblasts: 126.0" "Cancer enhanced" "Detected in many" "prostate cancer: 17.6" "Group enriched" "Detected in many" 5 "basal ganglia: 17.3;medulla oblongata: 9.3;pons: 10.9;thalamus: 4.6" "Immune cell enriched" "Detected in some" 122 "neutrophil: 139.4" "Lineage enriched" "Detected in many" 122 "granulocytes: 139.4" "Cell line enhanced" "Detected in many" "ASC TERT1: 684.4;BJ hTERT+: 1116.9;HSkMC: 651.1" "Region enhanced" "Detected in many" "basal ganglia: 28.1" "Group enriched" "Detected in many" 4 "basal ganglia: 32.3;olfactory bulb: 8.5;spinal cord: 15.9" "CAB000013, HPA052583, HPA056072" Enhanced NA NA 320000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 45: Enterocytes - Digestion" "CAB000013: AB_563478, HPA052583: AB_2681872, HPA056072: AB_2683027" "unprognostic (1.36e-1)" "unprognostic (1.02e-3)" "unprognostic (8.52e-2)" "unprognostic (2.95e-1)" "unprognostic (2.78e-2)" "unprognostic (6.52e-3)" "unprognostic (1.20e-1)" "unprognostic (1.67e-2)" "unprognostic (8.67e-2)" "unprognostic (1.96e-1)" "unprognostic (7.30e-3)" "unprognostic (1.31e-1)" "unprognostic (2.71e-3)" "unprognostic (1.50e-1)" "unprognostic (7.29e-2)" "unprognostic (1.06e-2)" "unprognostic (1.37e-2)" 103.9 1.0 0.7 4.5 17.3 11.5 38.5 1.5 1.9 22.7 0.3 1.9 333.5 13.3 22.5 2.3 1.9 13.4 4.3 0.1 0.6 302.5 56.1 27.6 10.3 9.3 2.3 0.9 1.2 0.5 0.6 73.0 10.9 79.6 3.4 0.1 6.1 44.5 20.3 1.9 289.7 1.5 0.9 7.9 1.6 1.3 4.6 16.6 1.2 23.5 12.3 6.0 7.6 0.4 0.1 0.0 0.9 0.3 280.1 684.4 1.6 160.3 1116.9 82.2 209.8 0.0 0.3 172.9 0.1 130.1 107.4 0.5 5.2 6.1 201.3 0.0 0.8 0.0 0.1 0.2 229.6 0.0 0.0 651.1 1.0 40.4 308.1 89.4 59.5 0.4 0.2 0.3 135.1 0.7 0.4 1.0 6.1 0.5 1.1 303.3 139.9 1.6 5.2 1.9 0.5 1.5 0.1 0.5 31.9 68.3 0.2 0.2 165.8 356.4 0.8 115.7 27.9 0.1 0.0 217.3 42.5 0.1 7.3 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.0 139.4 0.0 0.0 1.1 0.0 0.0 0.7 17.3 1.5 1.9 0.1 0.6 9.3 2.3 10.9 0.9 4.6 0.4 5.9 9.6 13.0 0.3 2.3 0.8 74.1 2.5 0.0 0.0 1.5 64.1 1.6 21.5 11.2 22.0 0.0 82.1 6.9 0.0 9.8 0.2 0.5 6.2 273.3 6.6 0.0 0.0 2.2 0.0 57.8 40.6 0.0 5.7 2.5 0.0 2.9 53.2 8.9 0.0 8.1 9.9 2.0 3.1 1.2 0.5 4.1 10.7 0.0 0.0 0.2 0.0 0.0 0.5 0.3 0.6 13.8 1.2 0.1 40.0 372.4 125.7 1.6 0.0 0.0 17.4 11.1 0.2 0.5 0.1 0.3 126.0 2.5 0.1 12.6 33.6 MMEL1 "MMEL2, NEPII, NL1, NL2, SEP" ENSG00000142606 "Membrane metalloendopeptidase like 1" Q495T6 1 2590639-2633016 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 24.6" "Cell type enhanced" "Detected in many" "Early spermatids: 131.2;Late spermatids: 36.1;Paneth cells: 54.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in some" 5 "SK-BR-3: 14.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA007876, HPA008205, CAB020786" Uncertain "Intracellular and membrane" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 29: Early spermatids - Spermatogenesis" "CAB020786: , HPA007876: AB_1854012, HPA008205: AB_1854011" "unprognostic (5.80e-2)" "unprognostic (4.61e-2)" "unprognostic (1.87e-1)" "unprognostic (4.27e-2)" "unprognostic (1.33e-1)" "unprognostic (2.71e-2)" "unprognostic (1.45e-1)" "unprognostic (7.96e-2)" "unprognostic (1.36e-2)" "unprognostic (2.37e-1)" "unprognostic (4.54e-3)" "unprognostic (2.44e-2)" "unprognostic (4.79e-2)" "unprognostic (3.18e-1)" "unprognostic (2.82e-1)" "unprognostic (2.18e-3)" "unprognostic (7.01e-4)" 2.9 1.4 0.6 0.0 0.6 0.0 3.0 0.5 0.9 3.2 0.4 3.7 2.6 0.7 0.9 4.8 2.9 0.0 0.5 0.5 0.8 3.7 0.5 2.8 0.0 1.0 1.0 0.4 2.0 0.6 0.7 0.0 0.8 6.5 0.3 0.1 1.6 0.3 0.2 0.7 4.2 0.0 0.7 2.5 8.2 24.6 0.7 0.0 1.1 0.0 0.0 3.1 3.2 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 2.3 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.5 0.0 0.1 0.0 14.2 0.0 0.0 1.3 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.0 1.0 4.7 0.3 2.6 0.2 0.4 1.0 0.4 0.7 0.0 2.7 1.3 0.6 1.8 3.6 0.1 4.2 1.7 0.6 0.6 0.5 0.9 0.5 0.8 1.0 1.0 0.8 0.7 0.7 0.6 5.9 0.0 0.0 0.3 0.4 0.0 5.2 5.2 1.2 0.0 10.3 8.9 1.1 20.0 10.2 18.4 0.0 0.0 0.3 12.1 0.0 9.4 131.2 7.1 0.5 2.3 1.2 2.5 0.1 3.4 0.0 1.3 8.6 7.3 0.0 0.0 1.4 0.2 1.2 0.0 0.2 16.5 2.0 1.0 0.2 36.1 1.8 2.4 0.0 0.0 0.9 0.5 0.0 0.5 0.0 4.0 54.9 1.2 0.2 6.7 20.8 0.1 8.8 0.2 0.0 0.0 0.6 0.6 1.1 0.6 0.0 0.0 0.8 0.4 9.7 12.6 MMP1 CLG ENSG00000196611 "Matrix metallopeptidase 1" P03956 11 102789401-102798160 "Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Collagen degradation, Host-virus interaction" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 75.7;stomach 1: 47.6;urinary bladder: 52.2" "Cell type enriched" "Detected in many" 10 "Pancreatic endocrine cells: 2239.5" "Cancer enhanced" "Detected in many" "head and neck cancer: 344.2" "Region enriched" "Detected in single" 7 "cerebral cortex: 1.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ hTERT+: 1139.1;HBF TERT88: 1094.4;HUVEC TERT2: 2954.4;WM-115: 1454.1" "Not detected" "Not detected" HPA004920 Approved Vesicles "Secreted to extracellular matrix" NA NA 7730000 55000 "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 17: WM-115 - Nervous system development" "Cluster 16: Pancreatic endocrine cells - Mixed function" Vesicles "HPA004920: AB_2667293" "unprognostic (4.11e-3)" "prognostic unfavorable (4.66e-4)" "unprognostic (4.20e-3)" "unprognostic (1.19e-3)" "unprognostic (6.46e-2)" "unprognostic (6.50e-2)" "prognostic unfavorable (4.22e-6)" "unprognostic (7.83e-3)" "unprognostic (2.94e-2)" "unprognostic (5.44e-2)" "unprognostic (1.11e-3)" "unprognostic (1.75e-1)" "prognostic unfavorable (9.86e-10)" "unprognostic (1.67e-2)" "unprognostic (1.49e-1)" "unprognostic (1.26e-2)" "unprognostic (5.11e-2)" 0.3 0.1 0.0 26.7 0.0 0.3 0.2 0.0 1.3 0.1 0.0 6.1 7.9 10.7 0.0 4.2 0.1 75.7 0.4 0.0 0.1 1.0 0.8 6.7 0.1 0.0 0.0 0.0 1.8 0.0 0.1 7.2 0.0 0.4 6.8 0.0 6.9 0.2 0.0 0.6 13.0 1.2 0.0 2.1 47.6 0.1 0.1 0.3 0.2 0.0 1.7 52.2 0.2 0.0 0.0 0.0 0.0 1.0 0.0 1.1 0.0 517.1 1139.1 456.6 118.2 9.1 1.0 0.0 5.2 275.5 175.2 4.6 0.0 160.0 1094.4 0.0 1.0 0.0 0.0 0.0 2.9 0.0 0.5 0.3 0.8 470.1 39.6 0.1 2954.4 0.0 1.5 0.5 0.3 0.0 0.0 0.0 0.4 189.3 20.8 0.0 0.1 0.0 0.7 2.2 0.0 0.1 4.8 0.0 1.6 0.1 0.5 0.0 155.0 374.1 0.6 16.8 1.3 0.1 0.0 0.0 8.8 0.0 1454.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.3 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 1.3 3.2 2.6 0.0 0.2 2.3 22.4 90.4 0.0 0.0 0.0 0.0 0.1 30.0 15.8 3.7 0.0 0.0 0.0 0.2 0.0 143.7 0.0 0.1 0.2 113.2 0.0 0.0 0.1 204.8 0.1 11.5 25.5 2.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 2.0 1.9 0.4 0.0 0.0 15.5 0.0 0.0 4.2 0.0 0.0 0.0 0.0 2239.5 1.2 0.0 0.0 30.9 0.7 0.2 1.3 0.0 0.0 1.8 10.5 0.0 0.0 0.0 0.3 0.1 0.1 0.1 0.1 44.3 MMP10 STMY2 ENSG00000166670 "Matrix metallopeptidase 10" P09238 11 102770502-102780628 "Cancer-related genes, Enzymes, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 34 "endometrium 1: 265.4" "Cell type enriched" "Detected in some" 38 "Basal respiratory cells: 3913.2" "Group enriched" "Detected in many" 4 "cervical cancer: 47.8;head and neck cancer: 102.2;lung cancer: 42.3" "Region enhanced" "Detected in single" "thalamus: 1.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ: 11.8;HUVEC TERT2: 15.1;SCLC-21H: 4.7" CAB002159 Uncertain Approved "Plasma membrane,Cytosol" "Secreted to extracellular matrix" NA NA 765000 "Cluster 89: Fibroblasts - ECM organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Cytosol "Plasma membrane" "CAB002159: AB_564103" "unprognostic (8.76e-2)" "unprognostic (3.38e-1)" "unprognostic (1.98e-3)" "unprognostic (2.72e-3)" "unprognostic (7.17e-3)" "unprognostic (1.52e-2)" "unprognostic (5.67e-8)" "unprognostic (2.08e-3)" "unprognostic (2.20e-1)" "unprognostic (1.75e-1)" "unprognostic (1.67e-2)" "unprognostic (2.67e-1)" "unprognostic (6.99e-5)" "unprognostic (2.66e-2)" "unprognostic (7.98e-2)" "unprognostic (5.46e-2)" "prognostic favorable (7.12e-4)" 0.1 0.0 0.1 7.7 0.0 0.1 0.1 0.0 0.8 1.2 0.0 0.4 1.1 265.4 0.0 0.2 0.0 1.3 0.0 0.2 0.3 0.1 1.0 2.0 0.1 0.1 0.3 0.2 0.2 0.0 0.0 1.3 0.3 1.4 0.2 0.0 1.6 0.0 0.0 0.1 0.8 0.2 0.0 0.0 2.9 0.5 1.9 0.6 0.0 0.2 0.7 4.4 3.2 0.0 0.0 0.1 0.8 0.2 0.0 0.0 0.2 11.8 0.6 0.1 0.1 0.3 0.0 0.0 3.3 1.8 0.2 2.7 0.0 1.3 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.4 0.5 0.0 15.1 0.0 0.7 0.0 0.0 0.0 0.0 0.3 2.8 0.5 1.6 0.0 0.0 0.0 0.0 0.6 4.7 0.0 2.4 0.0 0.0 0.8 0.0 0.0 1.9 3.5 1.2 0.4 0.5 0.0 0.0 0.1 0.6 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.8 0.2 0.3 0.1 0.3 0.3 0.0 1.9 0.0 0.1 0.0 0.0 0.0 0.0 0.8 51.3 3913.2 0.0 0.0 0.7 0.0 0.1 0.0 85.4 29.5 0.0 0.0 0.0 0.4 0.0 34.0 6.1 6.4 2.5 9.0 0.0 0.0 0.0 14.6 0.0 6.3 0.0 12.4 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 22.4 0.0 9.5 1.3 0.0 0.6 0.0 0.0 1.6 0.0 0.0 0.0 0.0 102.5 0.1 0.0 0.0 42.5 0.0 0.1 29.3 0.0 0.0 0.0 11.7 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.1 8.2 MMP11 STMY3 ENSG00000099953 "Matrix metallopeptidase 11" P24347 22 23768226-23784316 "Cancer-related genes, Enzymes, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "cervix: 64.8;endometrium 1: 142.8;placenta: 39.6" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 84.9;Extravillous trophoblasts: 37.6;Granulosa cells: 61.9;Smooth muscle cells: 35.8" "Cancer enhanced" "Detected in all" "pancreatic cancer: 119.1" "Low region specificity" "Detected in single" "Immune cell enriched" "Detected in single" 5 "plasmacytoid DC: 4.4" "Lineage enriched" "Detected in single" 5 "dendritic cells: 4.4" "Cell line enhanced" "Detected in many" "AN3-CA: 38.4;hTERT-RPE1: 19.7;REH: 16.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB002593, HPA055204, HPA068864" Approved Approved "Golgi apparatus,Cytosol" "Secreted to extracellular matrix" NA NA 640000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 36: Stromal cells - Cell proliferation" "Golgi apparatus" Cytosol "CAB002593: , HPA055204: , HPA068864: AB_2686051" "unprognostic (1.06e-1)" "unprognostic (3.08e-1)" "unprognostic (1.83e-1)" "unprognostic (1.84e-3)" "unprognostic (2.77e-2)" "unprognostic (6.73e-2)" "unprognostic (2.14e-2)" "unprognostic (5.15e-1)" "unprognostic (2.73e-2)" "unprognostic (2.20e-1)" "unprognostic (1.89e-3)" "unprognostic (7.04e-2)" "prognostic unfavorable (2.62e-4)" "unprognostic (8.05e-2)" "unprognostic (6.78e-2)" "unprognostic (1.10e-1)" "unprognostic (1.68e-2)" 3.3 1.6 0.4 1.4 0.3 0.5 2.2 0.3 1.2 64.8 0.3 3.9 6.8 142.8 0.1 1.0 5.7 6.8 7.2 0.3 0.4 2.5 0.6 1.4 3.9 0.4 0.4 12.5 1.3 3.3 0.5 39.6 0.4 1.9 3.5 0.0 5.3 1.5 0.9 3.8 6.0 9.4 0.4 1.4 2.6 6.7 0.4 3.1 1.3 0.9 1.7 2.9 3.6 0.4 0.3 0.0 4.8 38.4 5.7 8.3 0.1 0.6 10.4 1.3 0.8 0.4 1.3 1.3 5.1 2.8 1.8 0.2 2.2 0.0 0.4 0.0 0.8 0.0 0.0 2.2 4.2 0.0 0.0 5.4 0.9 1.1 0.1 19.7 6.0 0.4 0.6 0.0 1.4 0.3 0.1 0.1 1.4 1.2 0.2 16.6 0.0 0.4 0.7 0.0 6.0 10.3 3.9 0.6 0.0 5.9 3.6 0.0 2.7 0.6 0.0 1.6 0.1 0.1 0.2 5.0 0.3 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.7 0.1 0.0 0.0 0.0 0.0 4.4 0.0 0.1 0.4 0.3 0.3 1.2 0.3 0.4 0.4 0.4 0.4 0.4 0.4 0.4 1.2 0.0 2.5 0.3 3.4 1.0 0.8 0.8 0.6 0.4 1.9 0.5 6.1 1.5 0.1 0.0 0.0 0.7 1.8 0.4 1.9 8.6 10.3 4.4 84.9 0.9 1.8 0.0 0.2 0.7 37.6 8.4 1.5 4.1 1.3 61.9 1.1 0.0 0.8 0.0 0.4 1.3 2.0 0.0 1.1 10.5 0.6 1.0 1.8 1.0 0.0 0.3 0.0 0.0 0.2 1.4 0.2 0.4 0.2 0.5 0.1 2.2 0.8 0.5 0.0 2.7 35.8 3.1 5.5 0.5 0.6 18.6 2.0 5.7 1.0 0.3 MMP12 HME ENSG00000262406 "Matrix metallopeptidase 12" P39900 11 102862736-102874982 "Cancer-related genes, Enzymes, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 15.7;lymphoid tissue: 40.4;urinary bladder: 16.0" "Cell type enriched" "Detected in some" 9 "Extravillous trophoblasts: 303.4" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 13 "BJ: 3.3;fHDF/TERT166: 11.4;hTEC/SVTERT24-B: 6.3" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted to extracellular matrix" NA NA "Cluster 14: B-cells - Humoral immune response" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 38: Extravillous trophoblasts - Unknown function" "unprognostic (7.33e-2)" "unprognostic (3.20e-2)" "unprognostic (1.00e-2)" "unprognostic (1.03e-1)" "unprognostic (2.74e-1)" "unprognostic (1.67e-1)" "prognostic unfavorable (1.42e-4)" "unprognostic (1.69e-2)" "unprognostic (7.31e-2)" "unprognostic (1.52e-2)" "unprognostic (1.52e-3)" "unprognostic (5.45e-2)" "unprognostic (3.05e-6)" "unprognostic (1.08e-2)" "unprognostic (4.66e-2)" "unprognostic (1.73e-1)" "unprognostic (6.92e-2)" 0.5 0.0 0.0 40.4 0.1 0.0 0.4 0.0 0.0 0.1 0.0 13.5 6.8 0.6 0.0 0.4 0.0 2.6 0.0 0.0 0.3 0.9 0.1 0.6 7.0 0.1 0.1 0.0 0.1 0.0 0.0 7.4 0.1 1.3 15.7 0.0 2.4 0.0 0.0 0.5 7.8 2.2 0.1 3.7 3.5 0.0 0.1 3.9 0.0 0.0 19.4 16.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 0.3 0.1 0.0 0.0 0.0 0.0 0.0 11.4 0.1 0.4 0.0 0.0 0.3 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.4 0.4 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 3.2 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 1.1 0.0 0.0 0.1 0.7 0.0 0.0 0.0 18.6 303.4 0.4 0.0 0.2 0.0 0.0 0.0 0.0 15.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 32.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.5 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 4.5 0.1 0.0 0.0 2.2 MMP13 CLG3 ENSG00000137745 "Matrix metallopeptidase 13" P45452 11 102942995-102955732 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 12 "urinary bladder: 12.9" "Cell type enriched" "Detected in some" 12 "Basal respiratory cells: 426.0" "Cancer enhanced" "Detected in many" "head and neck cancer: 70.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "HaCaT: 17.9;PC-3: 6.7" "Not detected" "Not detected" "Not detected" "Not detected" CAB002742 Supported "Secreted to extracellular matrix" NA NA "Cluster 11: Basophils - Unknown function" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "CAB002742: " "unprognostic (8.98e-3)" "unprognostic (1.54e-1)" "unprognostic (4.75e-2)" "unprognostic (4.57e-2)" "unprognostic (3.05e-2)" "unprognostic (1.59e-3)" "unprognostic (1.32e-1)" "unprognostic (6.35e-3)" "unprognostic (1.69e-1)" "unprognostic (7.55e-3)" "unprognostic (2.24e-1)" "unprognostic (1.73e-8)" "unprognostic (2.12e-2)" "unprognostic (3.14e-1)" "unprognostic (4.14e-2)" "unprognostic (4.33e-2)" 0.1 0.0 0.0 0.2 0.1 0.4 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.0 0.0 0.2 0.1 0.0 0.0 0.0 0.5 0.0 0.2 0.2 0.0 0.0 0.1 0.0 0.1 0.2 0.1 0.0 0.1 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 12.9 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 17.9 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.5 0.1 0.0 0.0 0.0 6.7 0.0 0.0 0.1 0.0 1.8 0.0 0.0 0.1 2.0 0.0 0.0 0.0 0.0 0.0 2.4 1.3 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.3 0.3 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.2 0.2 0.1 0.2 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 8.7 426.0 0.0 0.0 0.0 0.0 0.2 0.0 33.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 6.8 0.0 0.0 0.0 2.2 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 15.8 MMP14 MT1-MMP ENSG00000157227 "Matrix metallopeptidase 14" P50281 14 22836560-22849041 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 244.0;Pancreatic endocrine cells: 144.7;Syncytiotrophoblasts: 122.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 923.8;HHSteC: 794.2;HSkMC: 887.0;hTERT-RPE1: 925.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009918, HPA051432" Approved Approved "Intermediate filaments,Cytosol" No No 1400000 "Cluster 46: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 38: Extravillous trophoblasts - Unknown function" Cytosol "Intermediate filaments" "CAB009918: AB_2250767, HPA051432: AB_2681484" "unprognostic (1.34e-1)" "unprognostic (1.37e-1)" "unprognostic (1.11e-2)" "unprognostic (2.81e-1)" "unprognostic (4.28e-2)" "unprognostic (1.12e-2)" "unprognostic (3.05e-3)" "unprognostic (5.91e-3)" "unprognostic (1.95e-1)" "prognostic unfavorable (9.48e-4)" "unprognostic (3.82e-3)" "unprognostic (7.31e-2)" "prognostic unfavorable (1.34e-4)" "unprognostic (5.02e-2)" "unprognostic (6.69e-2)" "unprognostic (1.00e-2)" "unprognostic (3.41e-3)" 151.5 31.7 5.6 59.9 5.0 1.6 101.5 5.7 7.5 181.3 61.8 77.2 39.5 167.3 19.0 92.1 82.1 148.2 41.3 6.6 7.2 35.9 13.2 91.8 24.8 11.9 8.4 90.2 36.0 65.3 14.2 118.9 9.2 59.9 36.6 9.6 78.1 45.5 18.8 127.5 69.4 106.0 7.3 30.8 57.7 11.7 13.2 13.0 50.0 16.1 30.8 103.9 111.1 10.6 90.6 1.2 26.3 2.0 923.8 651.6 455.9 270.1 606.4 93.3 158.5 21.3 337.4 0.9 146.4 301.9 24.6 216.3 0.3 262.2 99.7 1.1 0.6 37.2 1.7 5.0 794.2 0.4 1.3 887.0 148.7 334.7 288.3 925.5 492.9 0.6 0.8 2.1 185.1 0.7 0.4 79.4 14.7 17.7 52.4 2.1 96.0 0.2 61.4 148.1 0.3 0.6 187.3 0.3 574.2 104.4 1.0 79.5 436.8 724.9 53.7 198.2 329.6 0.8 1.6 1.1 410.9 0.6 396.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.6 5.0 5.7 7.5 6.6 7.2 11.9 8.4 9.2 7.3 13.2 10.6 13.9 12.8 3.0 2.0 3.4 34.0 23.4 105.4 39.3 0.0 14.1 17.5 4.7 50.1 42.2 7.3 0.0 105.6 0.3 19.9 11.7 63.0 0.4 16.1 81.6 35.2 7.8 0.0 0.0 28.7 244.0 84.0 25.5 14.8 3.8 9.3 32.9 2.7 89.5 0.0 0.0 24.5 34.6 20.2 32.7 2.4 72.1 38.0 37.4 4.7 21.5 14.3 0.0 0.5 0.1 144.7 33.0 54.9 0.3 21.8 19.9 11.7 46.8 0.8 39.5 11.1 73.9 0.8 0.8 33.7 34.2 122.7 2.5 15.6 18.6 37.9 MMP15 "MT2-MMP, MTMMP2, SMCP-2" ENSG00000102996 "Matrix metallopeptidase 15" P51511 16 58025754-58046901 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cholangiocytes: 55.8;Distal enterocytes: 109.3;Proximal enterocytes: 67.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 93.6;Hep G2: 51.1;OE19: 44.6;SK-BR-3: 47.3;WM-115: 78.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002611, HPA040390" Uncertain Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 28: BEWO - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane, Cytosol" Nucleoplasm "CAB002611: , HPA040390: AB_2676956" "unprognostic (1.76e-2)" "unprognostic (7.32e-2)" "unprognostic (2.69e-1)" "unprognostic (6.85e-2)" "unprognostic (3.09e-1)" "unprognostic (1.68e-1)" "unprognostic (6.88e-3)" "unprognostic (1.40e-1)" "unprognostic (3.02e-2)" "unprognostic (1.24e-2)" "unprognostic (4.81e-2)" "unprognostic (1.81e-1)" "prognostic favorable (8.54e-8)" "unprognostic (3.63e-2)" "unprognostic (1.36e-1)" "unprognostic (1.28e-1)" "prognostic favorable (3.08e-4)" 11.9 3.8 8.9 4.4 6.0 0.4 7.6 7.3 11.2 5.7 5.8 28.0 40.2 3.5 1.1 4.6 6.1 14.3 41.2 6.9 8.7 14.9 50.1 9.9 2.1 15.8 10.6 1.1 18.5 12.7 8.8 28.4 16.8 4.4 14.3 1.5 8.4 9.5 7.0 4.3 33.0 3.7 5.8 9.3 29.6 34.9 18.7 1.0 46.7 5.6 1.3 5.1 2.8 8.6 15.3 11.4 5.8 30.4 6.0 0.3 93.6 1.4 0.8 5.4 1.2 9.1 38.3 0.2 17.7 1.6 4.2 21.0 5.1 4.4 1.6 0.1 10.0 0.1 4.9 51.1 7.7 0.3 19.5 3.1 7.8 0.9 2.3 8.4 3.7 8.5 12.9 0.1 1.8 7.6 0.7 2.6 17.2 44.6 3.2 7.6 0.7 8.3 16.6 5.4 1.6 10.4 20.0 47.3 9.5 13.2 5.2 8.2 3.4 0.4 9.1 3.5 1.3 0.2 0.1 0.3 1.9 2.3 78.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 8.9 6.0 7.3 11.2 6.9 8.7 15.8 10.6 16.8 5.8 18.7 8.6 14.3 19.2 14.4 9.1 0.7 2.5 1.0 4.9 2.8 3.4 5.0 3.0 24.7 55.8 12.6 18.4 16.7 48.2 1.6 109.3 1.9 35.7 5.0 3.6 1.1 17.2 11.4 2.7 1.4 12.0 49.2 4.5 35.2 6.4 0.0 18.6 13.6 39.2 12.9 1.7 1.2 33.3 10.2 3.0 0.3 6.9 0.9 0.9 1.8 1.0 0.0 2.1 0.0 4.5 1.4 13.3 38.5 3.4 0.3 1.3 67.3 7.3 6.0 1.9 0.0 0.7 2.4 0.9 4.6 3.3 2.3 48.4 0.7 23.2 45.0 1.7 MMP16 "C8orf57, DKFZp761D112, MT3-MMP" ENSG00000156103 "Matrix metallopeptidase 16" P51512 8 88032011-88328025 "Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 5.8" "Cell type enriched" "Detected in many" 5 "Oligodendrocyte precursor cells: 2402.1" "Cancer enhanced" "Detected in many" "glioma: 4.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AN3-CA: 29.4;HUVEC TERT2: 12.8;SH-SY5Y: 16.2;U-138 MG: 13.7;WM-115: 28.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA023693 Uncertain Approved Vesicles,Cytosol "Secreted to extracellular matrix" NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 17: WM-115 - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol Vesicles "HPA023693: AB_1854025" "unprognostic (2.58e-1)" "unprognostic (2.42e-2)" "unprognostic (1.38e-1)" "unprognostic (1.87e-1)" "unprognostic (7.09e-2)" "unprognostic (3.31e-2)" "unprognostic (2.39e-3)" "unprognostic (1.45e-3)" "unprognostic (2.46e-1)" "unprognostic (2.61e-1)" "unprognostic (9.42e-2)" "unprognostic (2.92e-1)" "unprognostic (2.09e-8)" "unprognostic (6.90e-3)" "unprognostic (1.16e-1)" "unprognostic (3.62e-1)" "unprognostic (2.19e-3)" 0.7 0.3 4.6 0.3 5.8 0.0 1.8 2.2 5.4 1.7 0.0 0.8 0.1 1.6 0.6 0.4 0.6 2.6 0.8 5.1 3.9 0.1 0.1 0.2 0.2 1.0 1.5 1.0 0.6 0.2 0.5 1.0 1.3 0.9 0.4 0.4 0.3 0.7 0.1 0.2 0.3 1.3 1.4 0.4 0.3 0.4 3.0 0.4 1.0 0.5 0.2 0.9 0.5 3.3 0.0 0.2 7.9 29.4 1.0 2.0 0.0 10.9 1.6 3.0 1.8 0.0 0.1 0.0 0.0 4.9 1.8 0.0 5.8 0.0 3.7 0.0 3.4 0.0 0.0 0.0 2.4 0.0 0.5 1.4 0.0 4.4 1.3 5.4 12.8 0.1 0.0 1.1 1.7 0.0 0.0 0.0 1.7 0.0 3.0 0.3 0.6 0.0 0.6 0.1 0.2 16.2 0.0 0.0 0.2 2.2 1.1 0.0 7.1 13.7 7.7 0.2 4.2 0.0 0.0 0.0 5.7 0.0 28.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.6 5.8 2.2 5.4 5.1 3.9 1.0 1.5 1.3 1.4 3.0 3.3 2.2 0.0 0.0 20.5 0.1 1.1 0.0 0.0 0.6 4.4 0.8 1.4 1.0 0.0 0.0 0.0 2.1 0.1 0.1 0.0 1.9 0.0 6.5 0.5 15.9 5.2 0.0 0.0 443.4 0.0 0.1 16.0 0.0 0.4 0.0 1.9 1.4 0.0 0.4 1.7 300.3 0.0 0.0 0.0 1.6 6.5 0.9 0.4 1.8 10.3 0.0 3.0 0.0 2402.1 13.0 0.1 0.0 1.2 0.0 0.1 0.0 0.1 0.0 0.6 0.0 0.7 2.9 0.0 1.1 0.2 0.1 0.0 0.2 3.4 0.0 0.1 MMP17 MT4-MMP ENSG00000198598 "Matrix metallopeptidase 17" Q9ULZ9 12 131828393-131851783 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 37.2" "Group enriched" "Detected in many" 5 "Excitatory neurons: 47.0;Inhibitory neurons: 14.3;Melanocytes: 28.4;Oligodendrocyte precursor cells: 26.7" "Cancer enriched" "Detected in many" 10 "melanoma: 29.9" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 5 "REH: 29.6;SK-MEL-30: 60.4;WM-115: 87.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "Secreted to extracellular matrix" NA NA "Cluster 37: B-cells - Transcription" "Cluster 10: Brain - Neuronal signaling" "Cluster 17: WM-115 - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "unprognostic (9.11e-2)" "unprognostic (1.27e-2)" "unprognostic (1.69e-2)" "unprognostic (3.71e-3)" "unprognostic (5.62e-2)" "unprognostic (1.85e-2)" "unprognostic (8.90e-3)" "unprognostic (2.14e-2)" "unprognostic (2.60e-1)" "unprognostic (2.66e-4)" "unprognostic (7.68e-2)" "unprognostic (5.88e-2)" "unprognostic (9.26e-10)" "unprognostic (1.15e-2)" "unprognostic (2.65e-1)" "unprognostic (1.21e-3)" "unprognostic (2.81e-2)" 3.9 0.8 9.9 1.2 16.6 0.9 4.0 0.0 37.2 10.8 0.0 6.4 0.3 3.7 0.0 1.7 2.4 1.0 2.2 31.7 9.2 1.0 1.0 2.0 0.9 0.0 0.2 11.6 2.0 0.1 1.5 0.1 0.3 2.9 0.1 0.1 3.1 0.5 0.9 4.7 2.7 0.3 0.0 1.7 1.6 3.2 6.3 0.0 1.7 0.0 0.2 2.7 4.7 8.8 0.3 11.5 0.0 0.5 2.3 2.9 0.1 7.2 7.9 2.1 3.3 0.0 1.4 0.0 5.2 1.8 1.4 3.8 1.3 1.5 0.0 0.0 0.7 1.1 3.8 0.0 3.6 0.0 7.2 2.7 1.2 2.4 0.0 0.5 4.0 0.0 2.0 0.0 1.0 8.3 0.0 11.5 4.6 1.6 7.3 29.6 0.0 3.9 0.0 0.0 3.7 2.0 1.0 0.2 60.4 0.5 7.4 12.8 5.8 0.7 0.9 6.3 0.6 0.0 0.0 0.0 2.4 0.3 87.5 0.0 0.4 0.0 0.0 0.4 0.0 0.5 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.1 9.9 16.6 0.0 37.2 31.7 9.2 0.0 0.2 0.3 0.0 6.3 8.8 0.6 0.0 0.0 2.9 2.3 2.5 0.1 1.7 0.6 1.0 2.3 1.8 1.2 1.5 0.9 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 5.4 0.5 0.0 0.0 47.0 0.2 0.2 5.4 0.0 0.4 0.0 0.7 1.1 0.0 0.6 3.3 14.3 0.0 2.0 2.6 1.0 0.4 0.9 3.4 28.4 3.7 2.4 0.1 0.0 26.7 2.9 0.0 0.0 1.9 0.0 0.2 0.0 0.4 0.2 0.1 0.0 0.8 1.4 0.4 0.4 0.1 1.1 0.0 0.2 5.3 0.0 0.2 MMP19 "MMP18, RASI-1" ENSG00000123342 "Matrix metallopeptidase 19" Q99542 12 55835433-55842966 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted secreted proteins" "Angiogenesis, Collagen degradation, Differentiation" "Developmental protein, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 58.5" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 54.4;Fibroblasts: 52.8;Hofbauer cells: 30.8;Kupffer cells: 35.7;Langerhans cells: 100.7;Macrophages: 61.2" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in single" "thalamus: 1.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in many" 5 "BEWO: 75.6" "Region enriched" "Detected in many" 5 "olfactory bulb: 7.2" "Low region specificity" "Detected in all" HPA070804 Approved "Endoplasmic reticulum,Vesicles" "Secreted to extracellular matrix" NA NA 2100000 "Cluster 82: Adipose tissue - ECM organization" "Cluster 28: BEWO - Transcription regulation" "Cluster 41: Macrophages - Immune response" "Endoplasmic reticulum, Vesicles" "HPA070804: AB_2686315" "unprognostic (2.61e-1)" "unprognostic (6.56e-2)" "unprognostic (2.28e-2)" "unprognostic (2.42e-1)" "unprognostic (4.77e-3)" "unprognostic (4.77e-3)" "unprognostic (2.01e-2)" "unprognostic (4.03e-2)" "unprognostic (2.85e-2)" "unprognostic (4.30e-2)" "unprognostic (2.37e-1)" "unprognostic (2.09e-1)" "prognostic unfavorable (8.56e-9)" "unprognostic (5.06e-3)" "unprognostic (1.28e-3)" "unprognostic (2.73e-2)" "unprognostic (4.00e-2)" 58.5 3.6 0.0 11.4 0.1 0.7 18.3 0.0 0.3 10.4 0.5 7.3 1.2 20.7 0.5 2.3 17.2 25.6 8.8 0.1 0.1 5.7 2.7 25.4 2.8 0.1 0.1 11.9 7.2 0.5 0.8 10.8 0.2 3.3 3.3 0.1 3.1 2.3 0.9 5.5 8.7 8.7 0.1 27.4 9.6 0.4 1.3 2.9 4.4 0.6 6.9 9.6 6.2 0.1 1.5 0.0 0.2 0.0 7.8 12.4 75.6 10.1 10.6 3.9 4.4 0.6 0.6 0.0 0.0 12.8 0.3 0.0 0.0 3.0 4.0 0.8 0.0 0.0 0.3 0.1 6.5 0.0 0.6 12.1 0.4 1.9 2.4 6.2 0.7 0.0 0.2 0.1 11.2 0.0 0.0 0.2 0.3 0.0 0.2 0.0 2.8 0.0 1.7 4.7 0.0 0.0 0.2 0.0 0.0 1.4 0.0 0.2 15.7 2.2 5.0 0.2 0.3 0.1 0.0 0.0 8.4 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.3 0.1 0.1 0.1 0.1 0.2 0.1 1.3 0.1 2.8 0.0 4.6 0.7 1.3 7.1 0.3 1.9 0.6 0.4 0.3 0.3 0.7 11.5 3.3 0.0 4.2 18.6 0.7 0.0 0.0 0.3 0.5 2.4 20.8 1.5 0.0 0.0 0.2 0.5 54.4 52.8 1.1 1.7 2.5 0.4 3.6 0.7 30.8 0.0 0.2 0.1 0.0 35.7 100.7 0.9 5.9 61.2 12.4 1.9 22.5 0.4 0.0 0.0 0.3 0.1 0.0 5.3 1.0 0.3 0.0 0.1 1.5 1.7 0.0 3.8 7.6 0.2 0.2 1.0 4.3 18.7 0.9 0.2 0.0 0.4 MMP2 "CLG4, CLG4A, TBE-1" ENSG00000087245 "Matrix metallopeptidase 2" P08253 16 55389700-55506691 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Angiogenesis, Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "gallbladder: 1062.9" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 222.4;Extravillous trophoblasts: 467.9;Fibroblasts: 815.9;Leydig cells: 340.2;Peritubular cells: 419.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 5619.3;ASC TERT1: 1623.2;hTERT-RPE1: 6400.4;U-87 MG: 1812.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA001939, CAB002788" Approved Approved Vesicles "Secreted to extracellular matrix" NA NA 1600000000 220000000 "Cluster 46: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" Vesicles "CAB002788: , HPA001939: AB_1079395" "unprognostic (7.26e-2)" "unprognostic (1.36e-3)" "unprognostic (1.66e-1)" "unprognostic (2.14e-3)" "unprognostic (5.03e-2)" "unprognostic (1.20e-1)" "unprognostic (1.74e-1)" "unprognostic (9.36e-3)" "unprognostic (4.81e-3)" "unprognostic (3.79e-2)" "unprognostic (4.59e-3)" "unprognostic (6.12e-2)" "unprognostic (1.28e-3)" "unprognostic (1.59e-2)" "unprognostic (8.00e-2)" "unprognostic (8.98e-2)" "unprognostic (4.63e-2)" 518.9 68.3 3.9 135.1 4.0 1.2 328.9 4.9 7.8 514.1 9.4 173.8 57.4 453.6 192.6 121.5 190.6 1062.9 212.8 3.6 5.3 43.7 15.6 279.7 28.1 7.6 4.9 271.1 42.8 13.8 14.7 225.0 5.4 116.8 171.3 11.4 124.1 137.5 60.8 455.6 177.3 468.5 6.7 58.3 134.0 49.6 8.6 19.8 113.5 66.1 30.3 660.8 238.1 10.0 6.5 3.9 192.0 2.4 5619.3 1623.2 312.7 501.4 1146.1 99.4 79.0 0.2 2.1 0.5 391.7 891.0 37.0 54.2 1.2 4.6 57.0 0.7 0.9 0.7 12.9 3.0 530.6 0.4 14.8 1396.8 1.7 512.4 4.4 6400.4 651.1 0.5 0.7 2.4 334.7 0.0 0.4 8.2 152.4 0.5 1.6 0.4 46.1 0.9 16.1 7.6 3.2 345.0 93.3 0.8 2.1 849.0 1.6 36.0 924.6 1546.0 144.9 300.5 66.9 1.0 0.6 2.2 1812.3 28.3 289.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.9 4.0 4.9 7.8 3.6 5.3 7.6 4.9 5.4 6.7 8.6 10.0 38.4 0.0 0.5 0.0 0.0 122.1 14.1 48.8 9.1 30.5 3.1 16.8 4.4 0.0 3.1 11.0 0.0 5.6 0.5 0.1 0.0 2.5 12.5 7.7 222.4 46.9 28.2 0.0 0.0 0.4 467.9 815.9 12.2 5.4 0.0 0.0 13.2 0.1 28.2 1.7 0.2 0.1 2.0 1.6 180.7 40.2 340.2 11.8 128.1 27.2 0.0 7.7 0.0 5.0 0.0 9.3 0.0 419.0 2.8 5.6 0.0 0.2 1.1 2.5 13.1 80.0 65.3 1.2 2.8 6.6 102.3 17.2 10.3 35.2 0.0 4.4 MMP20 ENSG00000137674 "Matrix metallopeptidase 20" O60882 11 102576832-102625332 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Amelogenesis imperfecta" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Cell type enriched" "Detected in some" 7 "Early spermatids: 91.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 7 "OE19: 2.5" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted to extracellular matrix" NA NA "Cluster 21: OE19 - Mitochondria" "Cluster 23: Spermatids - Flagellum & Golgi organization" "unprognostic (4.62e-3)" "unprognostic (2.61e-2)" "unprognostic (1.68e-3)" "unprognostic (1.75e-1)" "unprognostic (2.13e-1)" "unprognostic (3.06e-1)" "unprognostic (2.97e-2)" "unprognostic (6.75e-2)" "unprognostic (9.58e-5)" "unprognostic (6.10e-2)" "unprognostic (2.35e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 91.8 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 12.0 0.3 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.4 0.0 0.0 0.4 0.0 0.0 0.0 0.6 0.0 0.0 6.6 0.0 0.0 0.0 0.4 0.0 0.0 0.5 0.0 0.0 0.0 0.4 MMP21 ENSG00000154485 "Matrix metallopeptidase 21" Q8N119 10 125753580-125775821 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" Heterotaxy "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enriched" "Detected in some" 14 "epididymis: 53.9" "Cell type enhanced" "Detected in some" "Distal tubular cells: 1.9;Granulosa cells: 1.4;Microglial cells: 1.9" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted to extracellular matrix" NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 40: Granulosa cells - Unknown function" "unprognostic (1.32e-2)" "unprognostic (1.28e-1)" "unprognostic (8.51e-2)" "unprognostic (2.19e-2)" "unprognostic (4.02e-2)" "unprognostic (2.21e-2)" "unprognostic (4.22e-3)" "unprognostic (1.01e-1)" "unprognostic (2.12e-1)" "unprognostic (1.48e-1)" "unprognostic (2.89e-2)" "unprognostic (3.62e-2)" "unprognostic (9.70e-8)" "unprognostic (1.30e-2)" "unprognostic (7.69e-2)" "unprognostic (7.00e-2)" "unprognostic (2.18e-1)" 0.2 0.3 0.4 0.6 0.7 0.7 0.2 1.7 0.7 0.2 0.2 0.2 0.5 0.5 53.9 0.5 0.4 0.7 0.8 0.5 0.4 0.1 0.3 0.2 1.0 0.3 0.3 3.7 0.7 0.0 0.1 0.1 0.2 0.5 0.1 1.8 1.2 0.2 0.3 1.2 0.4 0.2 0.1 0.6 0.4 1.0 0.5 0.0 0.5 0.0 0.2 0.2 0.0 0.9 0.4 0.2 0.6 0.4 0.1 0.0 0.6 0.4 0.0 0.0 0.0 0.4 0.0 0.5 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.2 0.4 0.1 0.9 0.4 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.1 0.3 0.0 0.2 0.2 0.3 0.3 0.0 0.3 0.2 0.1 0.1 0.0 0.3 0.1 0.2 0.2 0.0 0.0 0.2 0.1 0.1 0.2 0.5 0.2 0.2 0.3 0.5 0.4 0.2 0.1 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.7 1.7 0.7 0.5 0.4 0.3 0.3 0.2 0.1 0.5 0.9 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.1 0.0 1.4 0.0 0.0 0.1 0.0 0.8 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.9 0.0 0.5 0.0 0.5 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.1 0.3 0.1 0.4 0.0 0.0 0.0 0.0 0.2 0.1 0.0 MMP23B "MIFR, MIFR-1, MMP22" ENSG00000189409 "Matrix metallopeptidase 23B" O75900 1 1632163-1635263 "Enzymes, Predicted intracellular proteins, Transporters" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "ovary: 29.9" "Cell type enhanced" "Detected in many" "Fibroblasts: 90.5;Leydig cells: 98.2;NK-cells: 64.9;Peritubular cells: 177.9" "Cancer enhanced" "Detected in single" "ovarian cancer: 0.8" "Low region specificity" "Detected in single" "Immune cell enriched" "Detected in some" 5 "plasmacytoid DC: 11.3" "Lineage enriched" "Detected in many" 5 "dendritic cells: 11.3" "Cell line enhanced" "Detected in some" "HHSteC: 4.4;NTERA-2: 2.7;PC-3: 1.9;U-266/70: 3.9" "Region enriched" "Detected in some" 5 "cerebellum: 7.8" "Low region specificity" "Detected in some" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 89: Fibroblasts - ECM organization" "Cluster 29: U-266 - Adaptive immune response" "Cluster 33: Fibroblasts - ECM organization" "unprognostic (2.19e-2)" "unprognostic (6.31e-2)" "unprognostic (6.70e-3)" "unprognostic (1.29e-1)" "unprognostic (3.99e-2)" "unprognostic (9.31e-2)" "unprognostic (6.94e-2)" "unprognostic (1.20e-1)" "unprognostic (8.06e-2)" "unprognostic (8.37e-2)" "unprognostic (2.22e-1)" "unprognostic (2.33e-1)" "unprognostic (2.26e-11)" "unprognostic (1.60e-3)" "unprognostic (1.36e-1)" "unprognostic (2.44e-2)" "unprognostic (6.66e-2)" 7.1 2.8 0.4 0.3 0.5 1.3 4.1 0.1 1.0 16.7 0.0 5.0 1.9 15.4 0.0 2.8 11.0 2.9 15.0 0.3 0.0 3.2 3.3 14.3 1.1 0.4 0.0 29.9 1.6 0.0 5.7 2.8 0.1 11.8 0.1 0.1 1.0 1.1 0.5 3.1 3.4 1.2 0.0 3.0 4.3 5.2 0.1 0.0 2.4 0.0 0.1 11.9 10.9 0.2 0.6 0.0 0.0 1.8 0.0 0.0 0.8 0.0 0.0 0.1 0.0 0.4 0.5 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.7 0.5 0.2 1.2 4.4 0.2 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.1 0.0 0.4 0.0 0.2 2.7 0.0 1.9 0.9 0.0 1.1 0.0 0.0 0.4 0.2 0.3 0.0 0.1 0.0 0.5 0.0 0.4 0.2 0.1 0.3 0.0 3.9 0.2 1.1 0.0 0.2 0.1 0.0 0.2 0.0 1.5 0.0 0.9 0.0 0.3 1.0 0.0 0.1 0.0 0.7 0.1 2.2 0.1 11.3 0.3 1.7 0.4 0.5 0.1 1.0 0.3 0.0 0.4 0.0 0.1 0.0 0.1 0.2 2.2 0.0 0.5 1.0 1.1 13.4 0.8 0.7 0.6 1.3 1.7 1.5 9.6 1.5 0.4 1.8 0.0 4.0 27.4 3.0 0.0 1.2 1.0 4.0 3.5 2.2 3.0 2.7 0.3 0.5 2.2 90.5 4.6 1.0 0.0 1.4 12.1 1.0 5.7 3.3 0.6 1.9 4.1 1.0 18.5 6.2 98.2 1.3 19.6 0.0 1.2 0.5 64.9 0.0 0.2 4.3 0.9 177.9 4.3 0.5 2.7 1.0 0.5 7.7 0.0 0.7 5.3 2.1 10.5 0.7 15.8 10.3 8.1 2.1 1.7 0.9 MMP24 MT5-MMP ENSG00000125966 "Matrix metallopeptidase 24" Q9Y5R2 20 35226690-35276998 "Enzymes, Predicted membrane proteins, Predicted secreted proteins" "Cell adhesion" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "brain: 40.0" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 16.0;Excitatory neurons: 24.6;Horizontal cells: 15.2;Inhibitory neurons: 38.4;Oligodendrocyte precursor cells: 12.5;Oligodendrocytes: 12.0;Proximal tubular cells: 11.4" "Cancer enhanced" "Detected in many" "renal cancer: 11.4;testis cancer: 10.8" "Region enriched" "Detected in all" 5 "cerebellum: 40.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 36.3;CACO-2: 56.0;EFO-21: 15.8;RPTEC TERT1: 24.6;U-2 OS: 17.7" "Low region specificity" "Detected in all" "Region enriched" "Detected in all" 5 "cerebellum: 51.5" "HPA049280, HPA078816" Approved Approved "Nucleoli,Plasma membrane" "Secreted to extracellular matrix" Yes No "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 39: CACO-2 - Unknown function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoli, Plasma membrane" "HPA049280: , HPA078816: " "unprognostic (1.52e-3)" "unprognostic (1.36e-1)" "unprognostic (1.18e-1)" "unprognostic (4.51e-4)" "unprognostic (2.47e-2)" "unprognostic (7.61e-3)" "unprognostic (1.22e-1)" "unprognostic (4.59e-2)" "unprognostic (2.32e-2)" "unprognostic (8.82e-2)" "unprognostic (9.20e-3)" "unprognostic (7.12e-2)" "prognostic favorable (8.17e-11)" "unprognostic (3.32e-2)" "unprognostic (5.63e-2)" "unprognostic (1.69e-2)" "unprognostic (9.90e-4)" 3.4 1.0 6.1 0.5 5.8 0.7 0.5 40.0 8.1 0.7 3.5 0.7 2.1 1.3 0.1 0.3 2.2 0.6 0.6 6.0 5.6 7.8 0.5 4.7 0.4 4.4 5.6 0.4 5.8 0.3 3.8 0.2 5.4 1.7 0.2 2.5 0.5 4.2 0.3 1.2 1.4 2.0 2.7 0.4 0.6 0.4 7.2 0.0 0.7 0.1 0.0 0.4 0.3 4.8 0.6 36.3 0.1 0.2 0.2 0.0 1.0 1.9 2.3 3.8 2.0 56.0 9.7 0.0 15.8 2.5 1.2 0.6 8.5 0.0 1.6 0.2 0.3 1.9 1.2 0.6 0.0 0.1 0.4 0.2 0.2 0.1 0.1 1.0 0.1 0.1 0.1 0.5 0.4 0.5 0.1 0.2 13.6 0.1 2.4 0.1 0.2 0.0 24.6 0.1 14.1 9.7 2.5 0.7 0.3 2.9 0.5 0.3 0.6 7.4 17.7 1.8 0.7 0.3 0.2 0.1 1.6 0.2 1.1 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 6.1 5.8 40.0 8.1 6.0 5.6 4.4 5.6 5.4 2.7 7.2 4.8 0.3 16.0 1.5 5.2 0.0 0.1 0.2 0.0 0.0 3.9 0.2 0.8 0.5 8.6 1.3 1.8 0.0 0.1 0.1 0.7 5.9 8.5 0.6 0.8 0.3 1.4 0.0 0.0 24.6 0.9 0.1 0.6 0.0 0.5 0.0 0.1 0.4 0.4 0.0 15.2 38.4 0.1 0.0 0.6 0.0 0.0 0.3 0.1 1.8 10.3 0.0 0.2 0.0 12.5 12.0 1.9 0.1 0.0 0.0 0.4 2.3 11.4 0.0 0.4 0.0 0.2 0.2 0.1 0.3 0.0 0.3 0.0 0.2 0.0 0.1 0.1 MMP25 "MMP20, MMPL1, MT6-MMP" ENSG00000008516 "Matrix metallopeptidase 25" Q9NPA2 16 3046062-3060726 "Enzymes, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 33.1;lymphoid tissue: 81.8" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 6.7;Langerhans cells: 5.8;monocytes: 15.0" "Cancer enriched" "Detected in many" 5 "testis cancer: 7.1" "Low region specificity" "Detected in single" "Group enriched" "Detected in some" 5 "basophil: 18.3;neutrophil: 20.3" "Lineage enriched" "Detected in single" 39 "granulocytes: 20.3" "Cell line enriched" "Detected in some" 15 "HMC-1: 102.2" "Not detected" "Not detected" "Low region specificity" "Detected in many" "CAB025177, HPA055640" Uncertain Supported "Plasma membrane" "Secreted to blood" NA NA 120000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 2: Immune cells - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 3: Monocytes - Immune response regulation" "Plasma membrane" "CAB025177: , HPA055640: " "unprognostic (4.51e-3)" "unprognostic (9.28e-3)" "unprognostic (7.57e-2)" "unprognostic (2.95e-3)" "unprognostic (2.26e-1)" "prognostic favorable (1.09e-5)" "unprognostic (1.36e-1)" "unprognostic (7.39e-3)" "unprognostic (7.63e-3)" "unprognostic (2.29e-2)" "unprognostic (1.51e-1)" "unprognostic (2.53e-2)" "unprognostic (2.37e-3)" "unprognostic (1.17e-2)" "unprognostic (8.30e-2)" "unprognostic (4.01e-1)" "unprognostic (2.02e-1)" 5.8 0.4 0.5 15.1 0.4 33.1 1.4 0.3 1.6 0.7 0.6 1.7 1.1 0.5 0.1 1.3 6.2 1.1 2.4 0.3 0.3 1.4 2.9 14.4 2.6 0.6 0.5 0.4 1.2 0.2 0.8 1.0 0.6 1.0 1.4 0.0 1.2 0.1 0.5 0.7 3.5 0.9 0.3 81.8 1.9 0.4 0.7 1.4 1.2 3.5 1.9 2.2 0.9 0.3 0.0 0.0 1.2 2.9 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.7 0.7 0.1 0.0 6.7 0.5 0.0 0.0 0.0 0.0 0.2 102.2 0.1 0.1 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.3 0.0 5.7 2.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.0 0.0 0.2 0.3 7.0 0.3 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.1 1.1 0.1 18.3 0.2 4.0 0.0 0.0 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 20.3 0.5 0.0 0.4 0.2 0.0 0.5 0.4 0.3 1.6 0.3 0.3 0.6 0.5 0.6 0.3 0.7 0.3 1.0 3.2 6.7 0.0 0.7 0.4 0.4 0.2 0.0 0.8 2.0 1.3 1.0 0.0 0.8 1.8 0.0 0.0 1.8 0.2 0.0 0.4 0.0 1.2 1.2 1.0 0.0 2.7 1.6 0.6 0.2 0.6 1.1 3.8 1.3 0.2 0.0 0.3 0.1 0.0 1.9 0.2 0.0 3.5 5.8 0.0 0.0 3.3 0.0 1.0 15.0 0.3 3.1 1.5 0.5 1.3 0.0 0.7 0.8 0.4 1.2 0.2 0.1 0.0 0.0 0.7 0.9 0.1 0.2 0.6 0.3 0.0 4.0 0.1 0.3 0.3 MMP26 "endometase, MGC126590, MGC126592" ENSG00000167346 "Matrix metallopeptidase 26" Q9NRE1 11 4704927-4992429 "Enzymes, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in single" 24 "endometrium 1: 13.1" "Group enriched" "Detected in some" 7 "Endometrial ciliated cells: 44.8;Glandular and luminal cells: 171.1" "Cancer enriched" "Detected in some" 4 "endometrial cancer: 8.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted to extracellular matrix" NA NA "Cluster 89: Fibroblasts - ECM organization" "Cluster 44: Endometrium - Transcription" "unprognostic (4.21e-3)" "unprognostic (2.63e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 44.8 14.6 0.3 0.0 0.0 0.0 0.0 0.0 0.4 0.0 171.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 MMP27 ENSG00000137675 "Matrix metallopeptidase 27" Q9H306 11 102691487-102705769 "Enzymes, Predicted intracellular proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "breast: 4.7;salivary gland: 1.9;skin 1: 2.4" "Cell type enhanced" "Detected in some" "Basal squamous epithelial cells: 1.2;Fibroblasts: 4.2;Langerhans cells: 1.8;Suprabasal keratinocytes: 1.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA069097 Approved "Intracellular and membrane" NA NA "Cluster 31: Skin - Epidermis development" "Cluster 50: Fibroblasts - ECM organization" "HPA069097: AB_2686085" "unprognostic (3.99e-2)" "unprognostic (2.37e-4)" "unprognostic (1.25e-3)" "unprognostic (1.63e-1)" "unprognostic (4.60e-1)" 1.2 0.0 0.0 0.0 0.0 1.3 4.7 0.0 0.0 0.2 0.0 0.4 0.1 0.3 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 1.9 0.0 0.4 2.4 0.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 1.4 0.1 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.0 1.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 4.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 1.3 0.0 0.1 0.0 0.0 0.0 MMP28 "EPILYSIN, MM28, MMP-25, MMP-28" ENSG00000271447 "Matrix metallopeptidase 28" Q9H239 17 35756249-35795707 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 47.7;Basal respiratory cells: 56.8;Distal enterocytes: 82.0;Paneth cells: 46.2;Proximal enterocytes: 47.2;Urothelial cells: 43.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "naive CD4 T-cell: 6.3;naive CD8 T-cell: 3.7" "Lineage enriched" "Detected in single" 7 "T-cells: 6.3" "Cell line enhanced" "Detected in some" "CAPAN-2: 13.8;HaCaT: 86.9;hTCEpi: 38.3;OE19: 41.7;RT4: 15.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA057288, HPA057890" Approved "Nucleoplasm,Focal adhesion sites" "Secreted to extracellular matrix" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 27: Brain & Skin - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "Focal adhesion sites" "HPA057288: , HPA057890: " "unprognostic (7.99e-3)" "unprognostic (3.27e-1)" "unprognostic (2.20e-1)" "unprognostic (1.01e-1)" "unprognostic (7.52e-2)" "unprognostic (1.63e-1)" "unprognostic (6.90e-2)" "unprognostic (1.09e-2)" "unprognostic (1.51e-1)" "unprognostic (1.99e-1)" "prognostic unfavorable (6.28e-6)" "unprognostic (9.37e-2)" "unprognostic (1.31e-1)" "unprognostic (8.87e-2)" "unprognostic (1.74e-1)" "unprognostic (1.76e-2)" "unprognostic (3.27e-3)" 14.7 2.0 18.7 0.5 18.1 0.2 8.3 12.1 18.8 4.1 11.9 17.5 1.8 5.2 2.1 13.5 6.1 1.4 3.8 16.2 15.6 1.9 0.3 14.1 0.2 15.2 17.8 1.1 0.8 0.1 1.3 2.0 12.9 5.0 10.5 3.0 2.5 3.5 1.8 23.7 10.2 4.1 14.4 1.1 8.8 22.3 19.3 0.3 5.9 2.4 3.2 16.3 7.6 13.9 0.2 0.8 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 13.8 0.1 1.5 0.0 0.1 86.9 0.0 0.2 0.0 0.0 0.7 0.0 0.2 0.0 4.3 0.0 0.0 1.2 38.3 0.0 3.1 0.7 0.3 0.3 0.0 0.2 0.0 0.3 0.1 0.3 0.0 41.7 0.1 0.8 0.0 0.0 0.0 15.7 0.2 0.7 0.8 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.6 0.0 1.1 0.6 0.2 1.0 0.0 0.4 6.3 3.7 0.0 0.9 0.2 0.9 0.0 0.4 18.7 18.1 12.1 18.8 16.2 15.6 15.2 17.8 12.9 14.4 19.3 13.9 31.5 28.9 26.5 47.7 0.4 38.5 5.3 56.8 21.1 2.7 1.0 1.5 1.3 7.2 15.2 7.3 0.0 0.0 0.2 82.0 0.0 1.2 6.7 0.1 0.0 16.8 3.6 0.4 2.8 0.4 0.0 4.4 12.2 0.1 0.0 0.0 17.9 0.0 0.1 1.7 4.8 32.9 2.0 0.0 1.8 13.4 1.2 0.5 3.6 10.3 0.4 9.4 1.0 1.0 0.6 16.7 46.2 3.0 0.1 8.6 47.2 0.8 4.5 0.5 6.6 0.7 5.5 1.1 3.7 34.9 33.1 0.0 1.0 0.1 21.5 43.9 MMP3 "STMY, STMY1" ENSG00000149968 "Matrix metallopeptidase 3" P08254 11 102835801-102843609 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 90.7;salivary gland: 286.1" "Cell type enhanced" "Detected in some" "Basal prostatic cells: 20.4;Basal respiratory cells: 25.8;Early spermatids: 24.2;Extravillous trophoblasts: 13.4;Fibroblasts: 17.9;Prostatic glandular cells: 11.9;Smooth muscle cells: 10.2" "Cancer enhanced" "Detected in many" "head and neck cancer: 59.9" "Region enriched" "Detected in some" 4 "thalamus: 7.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 18 "BJ: 1545.7;BJ hTERT+: 4229.3;fHDF/TERT166: 1846.6" "Not detected" "Not detected" "Region enhanced" "Detected in some" "hippocampal formation: 3.2" HPA007875 Uncertain Supported Vesicles "Secreted to extracellular matrix" NA NA 2540000 460000 "Cluster 24: Salivary gland - Salivary secretion" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 50: Fibroblasts - ECM organization" Vesicles "HPA007875: AB_1079396" "unprognostic (2.27e-1)" "prognostic unfavorable (9.73e-4)" "unprognostic (1.63e-3)" "unprognostic (5.11e-3)" "unprognostic (3.78e-1)" "unprognostic (5.11e-2)" "unprognostic (5.26e-6)" "unprognostic (3.46e-2)" "unprognostic (7.14e-2)" "unprognostic (2.87e-1)" "prognostic unfavorable (4.09e-4)" "unprognostic (3.26e-2)" "unprognostic (1.22e-15)" "unprognostic (3.17e-1)" "unprognostic (1.55e-1)" "unprognostic (3.43e-2)" "unprognostic (2.34e-1)" 90.7 0.1 0.3 20.1 0.4 0.0 36.6 0.2 1.6 0.3 0.1 6.1 2.4 38.1 0.2 0.8 0.2 1.9 0.2 0.4 1.6 0.4 1.6 0.3 0.0 0.4 0.4 0.1 0.3 0.1 0.9 0.4 0.3 2.2 2.3 0.0 286.1 2.2 39.6 63.7 4.5 1.6 0.3 0.0 10.5 0.1 7.3 0.1 2.6 0.4 1.3 13.9 0.5 0.3 0.0 0.0 0.0 0.1 0.4 0.0 0.0 1545.7 4229.3 27.0 8.7 0.1 0.2 0.0 0.0 1846.6 96.9 0.0 0.1 0.1 45.1 0.0 0.0 0.0 0.0 1.0 0.7 0.0 0.0 4.6 0.2 122.0 5.3 0.0 0.0 0.0 0.2 0.3 4.7 0.0 0.0 0.0 0.2 0.4 0.9 0.0 0.2 0.0 0.1 0.0 0.1 0.0 2.3 0.0 0.0 0.9 0.0 0.3 0.0 140.5 13.1 1.6 0.5 0.0 0.0 0.2 56.8 0.0 7.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.2 1.6 0.4 1.6 0.4 0.4 0.3 0.3 7.3 0.3 0.0 3.2 0.0 0.0 0.0 8.4 20.4 25.8 0.0 0.0 0.1 0.1 0.3 4.3 7.6 0.0 0.0 0.1 0.0 0.0 0.0 0.8 24.2 0.0 0.3 0.5 0.0 0.0 0.2 1.4 13.4 17.9 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 4.1 0.0 2.2 1.2 0.0 0.3 0.0 0.0 0.6 0.0 0.0 0.0 0.0 3.5 4.0 0.0 0.0 11.9 1.0 0.9 0.1 0.0 0.0 1.8 10.2 0.0 1.8 0.0 3.4 0.3 0.6 0.0 0.8 7.4 MMP7 "MPSL1, PUMP-1" ENSG00000137673 "Matrix metallopeptidase 7" P09237 11 102520508-102530750 "Cancer-related genes, Enzymes, Plasma proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 509.9;salivary gland: 267.9;urinary bladder: 211.2" "Cell type enriched" "Detected in many" 8 "Ductal cells: 8176.2" "Cancer enhanced" "Detected in all" "pancreatic cancer: 352.1" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 145.9;CAPAN-2: 815.9;EFO-21: 189.8;RPTEC TERT1: 350.1" "Not detected" "Not detected" "Not detected" "Not detected" "CAB025869, HPA051358" Supported Approved Nucleoplasm,Vesicles "Secreted to extracellular matrix" NA NA 2810000 35000 "Cluster 5: Breast - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 1: Pancreatic cells - Digestion" "Nucleoplasm, Vesicles" "CAB025869: , HPA051358: AB_2681452" "unprognostic (1.06e-3)" "unprognostic (9.51e-2)" "unprognostic (4.15e-2)" "unprognostic (1.38e-1)" "unprognostic (7.70e-3)" "unprognostic (7.28e-2)" "prognostic unfavorable (2.53e-4)" "prognostic unfavorable (3.38e-4)" "unprognostic (3.96e-2)" "unprognostic (5.63e-2)" "unprognostic (6.59e-3)" "unprognostic (1.51e-1)" "unprognostic (6.36e-3)" "unprognostic (1.42e-2)" "unprognostic (5.54e-2)" "unprognostic (1.48e-1)" "unprognostic (1.46e-1)" 3.8 0.1 0.0 2.0 0.0 0.3 168.7 0.0 0.3 13.3 0.0 1.6 0.6 97.4 27.9 21.3 91.2 509.9 0.2 0.0 0.0 140.2 3.4 31.6 1.9 0.0 0.0 0.7 85.2 0.0 0.3 0.8 0.0 54.0 1.0 0.0 267.9 34.9 0.1 32.4 0.6 4.8 0.0 0.2 7.3 0.6 0.4 3.3 0.4 0.0 29.3 211.2 1.7 0.0 0.2 145.9 0.0 0.4 0.0 0.0 0.2 0.0 2.1 0.1 0.1 1.9 815.9 0.0 189.8 0.0 0.0 1.1 0.0 0.1 0.1 0.7 0.0 0.0 0.0 0.6 1.0 0.1 0.2 0.7 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.2 0.1 0.0 0.5 11.8 0.0 0.0 0.0 0.0 350.1 1.0 0.0 0.0 0.0 0.0 0.0 3.9 0.3 0.1 0.0 0.7 3.0 0.0 1.6 0.1 0.6 0.4 1.0 5.9 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.7 86.6 43.3 0.0 1.5 1.0 382.2 135.4 1.2 0.0 124.2 93.7 0.7 100.1 401.2 1017.0 0.0 0.7 2.9 1.2 0.0 8176.2 6.1 62.1 3.3 8.8 0.0 0.0 0.0 209.4 0.3 3.4 0.0 124.6 2.5 0.0 0.0 0.0 98.0 0.0 0.0 0.0 38.7 0.6 0.3 10.3 11.8 12.6 0.0 0.0 65.2 0.0 0.0 0.0 0.0 850.9 0.0 0.0 0.1 603.3 0.0 33.9 72.6 0.0 0.0 0.0 31.4 0.1 0.2 17.0 2.4 0.8 3.6 0.0 2.3 840.8 MMP8 CLG1 ENSG00000118113 "Matrix metallopeptidase 8" P22894 11 102711796-102727050 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 36 "bone marrow: 501.1" "Group enriched" "Detected in some" 6 "Hofbauer cells: 4.0;Macrophages: 1.5" "Cancer enriched" "Detected in single" 17 "melanoma: 5.7" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "non-classical monocyte: 1.7" "Lineage enhanced" "Detected in single" "monocytes: 1.7" "Cell line enriched" "Detected in some" 8 "WM-115: 70.7" "Not detected" "Not detected" "Not detected" "Not detected" "HPA021221, HPA021763, HPA022935" Enhanced Approved Vesicles "Secreted to extracellular matrix" NA NA 360000 "Cluster 7: Monocytes - Unknown function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 17: WM-115 - Nervous system development" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Vesicles "HPA021221: AB_1854043, HPA021763: , HPA022935: AB_1854044" "unprognostic (3.03e-1)" "unprognostic (8.49e-5)" "unprognostic (1.08e-2)" "unprognostic (3.95e-3)" "unprognostic (1.80e-1)" "unprognostic (1.01e-2)" "unprognostic (7.68e-3)" "unprognostic (1.27e-1)" "unprognostic (4.92e-2)" "unprognostic (6.64e-3)" "unprognostic (2.45e-6)" "unprognostic (2.33e-4)" "unprognostic (1.33e-1)" "unprognostic (4.97e-1)" "unprognostic (2.30e-2)" 0.5 0.0 0.0 0.3 0.1 501.1 0.2 0.1 0.2 0.0 0.2 0.1 0.0 1.9 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.2 0.6 4.1 0.2 0.1 0.0 0.0 0.0 0.0 0.2 0.7 0.2 0.0 0.0 0.0 0.2 0.0 0.1 0.5 0.0 0.2 0.0 13.8 0.1 0.0 0.6 2.6 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 9.1 0.0 0.0 0.1 0.0 4.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 70.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.7 0.0 0.0 0.9 0.0 0.1 0.1 0.2 0.0 0.0 0.1 0.0 0.2 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 MMP9 CLG4B ENSG00000100985 "Matrix metallopeptidase 9" P14780 20 46008908-46016561 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 11 "bone marrow: 376.0;lymphoid tissue: 105.3" "Group enriched" "Detected in many" 5 "Hofbauer cells: 260.1;Langerhans cells: 606.0;Macrophages: 230.6" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in some" 4 "cerebral cortex: 3.1;thalamus: 4.8" "Immune cell enriched" "Detected in some" 127 "neutrophil: 272.2" "Lineage enriched" "Detected in single" 341 "granulocytes: 272.2" "Cell line enriched" "Detected in some" 13 "NB-4: 360.6" "Low region specificity" "Detected in many" "Not detected" "Not detected" "CAB000348, HPA001238, HPA063909, CAB068199, CAB068200, CAB068201" Enhanced Approved Cytosol "Secreted to blood" NA NA 43300000 61000000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 24: NB-4 - Immune response" "Cluster 4: Macrophages - Innate immune response" Cytosol "CAB000348: , CAB068199: AB_2665675, CAB068200: AB_2665676, CAB068201: AB_2665677, HPA001238: AB_1079398, HPA063909: AB_2685150" "unprognostic (4.62e-2)" "unprognostic (1.64e-1)" "unprognostic (2.85e-2)" "prognostic favorable (2.55e-4)" "unprognostic (6.65e-3)" "unprognostic (2.82e-1)" "prognostic unfavorable (7.19e-4)" "unprognostic (1.54e-1)" "unprognostic (8.57e-2)" "unprognostic (3.21e-2)" "unprognostic (4.15e-2)" "unprognostic (1.96e-1)" "prognostic unfavorable (4.05e-5)" "unprognostic (4.65e-1)" "unprognostic (9.85e-3)" "unprognostic (2.48e-2)" "unprognostic (2.17e-3)" 19.5 0.6 0.5 61.9 0.8 376.0 8.2 0.4 3.1 2.9 0.8 5.7 11.6 1.0 0.0 2.2 2.2 3.0 3.2 0.3 0.9 2.6 3.8 21.1 103.2 0.8 0.5 0.8 1.6 0.1 1.1 2.0 0.7 1.9 3.4 0.6 3.6 0.4 0.7 3.2 12.4 1.9 0.4 105.3 11.3 1.3 4.8 17.0 2.1 0.9 36.5 12.0 1.1 0.2 0.2 0.4 0.2 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 3.3 0.3 28.8 0.0 0.3 0.4 0.0 1.4 0.0 0.3 0.5 0.1 0.0 0.0 0.0 0.6 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.4 0.0 4.0 0.0 360.6 0.8 0.0 0.2 0.4 0.3 0.1 0.0 0.0 0.6 0.6 0.0 0.6 0.0 3.7 0.3 1.2 0.3 10.3 10.9 0.1 0.3 0.3 0.2 0.2 0.1 0.8 0.2 0.0 0.7 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 272.2 0.0 0.3 0.0 0.0 0.5 0.5 0.8 0.4 3.1 0.3 0.9 0.8 0.5 0.7 0.4 4.8 0.2 0.7 0.0 5.5 0.0 3.9 34.3 0.1 61.5 0.0 3.8 0.5 2.0 0.4 1.5 0.9 0.0 8.4 1.5 2.0 0.0 0.0 0.8 0.9 0.0 0.1 7.2 0.0 0.0 0.1 1.8 2.4 2.5 0.0 0.1 1.3 0.2 0.0 0.0 260.1 3.3 0.2 0.5 0.0 1.3 606.0 0.3 0.0 230.6 56.9 0.0 2.3 1.2 0.0 0.0 0.0 1.8 0.0 0.0 0.9 0.1 0.0 0.3 6.9 5.3 0.0 0.2 45.5 6.7 11.2 0.2 28.1 1.9 3.4 0.3 0.0 0.1 MPND FLJ14981 ENSG00000008382 "MPN domain containing" Q8N594 19 4343527-4360086 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 84.7;Paneth cells: 42.7;Proximal enterocytes: 50.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043274, HPA045475" Approved Approved "Nucleoplasm,Nucleoli rim" No No "Cluster 38: Basophils - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoli rim" Nucleoplasm "HPA043274: AB_2678403, HPA045475: AB_2679339" "unprognostic (3.16e-2)" "prognostic favorable (2.99e-4)" "unprognostic (4.85e-2)" "prognostic favorable (6.12e-4)" "unprognostic (8.60e-2)" "unprognostic (5.37e-3)" "unprognostic (3.16e-2)" "prognostic favorable (1.55e-4)" "unprognostic (1.23e-1)" "unprognostic (2.87e-2)" "unprognostic (3.94e-3)" "unprognostic (5.18e-2)" "prognostic favorable (7.04e-4)" "unprognostic (2.22e-3)" "unprognostic (3.22e-1)" "unprognostic (5.44e-2)" "unprognostic (9.04e-2)" 10.5 21.9 22.6 9.3 22.4 15.8 10.7 27.1 35.0 13.2 20.8 25.4 30.6 11.9 8.6 18.1 11.5 9.5 22.4 23.1 20.5 22.7 46.5 12.6 11.7 22.7 20.7 13.0 24.4 15.4 11.0 6.9 23.3 19.0 16.2 4.0 17.2 9.6 23.2 15.6 19.8 6.5 19.4 15.2 20.1 6.6 20.6 10.2 13.3 14.4 7.1 15.2 12.7 25.0 16.0 13.2 21.3 24.6 13.1 6.1 21.7 7.6 7.2 6.2 7.6 25.6 8.1 14.4 23.3 9.9 18.2 16.1 9.8 13.2 3.4 16.4 21.5 11.0 18.4 37.4 10.0 14.9 19.1 9.4 9.4 6.8 7.1 9.3 18.9 37.4 6.0 36.4 7.8 41.8 35.4 12.6 9.8 26.5 18.2 28.8 6.5 21.0 15.5 25.4 23.7 24.3 13.5 19.4 9.9 12.1 13.0 18.1 7.3 9.8 10.4 60.4 15.4 30.1 20.1 9.7 10.9 8.3 11.5 9.3 3.1 1.5 1.3 3.7 2.1 1.0 1.6 1.9 2.9 1.6 1.0 1.1 0.8 1.7 1.8 2.9 3.7 1.3 22.6 22.4 27.1 35.0 23.1 20.5 22.7 20.7 23.3 19.4 20.6 25.0 6.1 0.0 3.7 1.6 5.1 5.4 8.4 1.4 3.4 8.2 9.5 8.5 13.9 11.5 2.7 11.0 2.1 13.6 9.8 84.7 0.0 4.1 0.8 8.0 6.1 6.0 16.7 2.5 2.6 5.1 11.9 5.2 9.2 8.9 4.5 7.8 5.7 23.5 14.8 6.7 2.4 31.2 2.0 26.0 9.6 3.9 6.2 14.4 3.6 1.9 8.8 8.6 21.6 3.5 2.1 4.3 42.7 3.8 7.7 6.9 50.7 15.0 2.3 5.6 6.6 6.1 11.7 0.2 7.6 7.8 8.4 10.4 6.3 9.1 34.6 9.6 MYSM1 KIAA1915 ENSG00000162601 "Myb like, SWIRM and MPN domains 1" Q5VVJ2 1 58643440-58700077 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Immunity, Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Chromatin regulator, DNA-binding, Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 106.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA054291, HPA057306" Approved Supported Nucleoplasm,Nucleoli NA NA "Cluster 6: Non-specific - Transcription" "Cluster 50: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" Nucleoplasm Nucleoli "HPA054291: AB_2682438, HPA057306: " "unprognostic (2.95e-3)" "unprognostic (3.64e-2)" "unprognostic (3.20e-2)" "unprognostic (8.68e-2)" "unprognostic (2.08e-2)" "prognostic favorable (5.09e-5)" "unprognostic (8.12e-3)" "unprognostic (9.63e-3)" "unprognostic (5.72e-3)" "unprognostic (3.74e-1)" "unprognostic (2.25e-1)" "unprognostic (4.56e-2)" "unprognostic (2.38e-3)" "unprognostic (4.22e-2)" "unprognostic (1.83e-1)" "unprognostic (8.45e-2)" "unprognostic (1.44e-2)" 11.2 7.5 4.0 4.4 3.9 12.5 12.0 4.3 5.9 11.9 4.2 11.8 5.4 10.6 6.2 10.0 10.2 3.1 10.5 4.1 3.9 7.2 8.0 10.1 6.3 3.9 3.7 13.2 12.1 5.9 8.7 4.4 3.9 9.6 4.4 8.4 11.8 4.1 10.0 10.5 12.6 3.6 3.7 11.4 9.9 4.4 3.9 5.3 11.5 3.1 4.9 9.3 11.1 4.4 10.1 2.6 5.0 6.7 6.0 7.2 10.5 5.9 5.6 5.1 3.9 5.3 4.2 10.3 1.8 3.8 4.8 7.4 7.7 2.1 11.0 6.2 4.3 11.3 2.1 5.1 7.4 19.6 9.7 5.4 5.9 7.5 3.8 6.1 1.2 4.2 12.6 6.3 6.8 2.6 7.8 16.3 11.4 3.5 3.5 7.3 16.4 6.1 4.6 3.8 5.8 6.6 4.4 9.4 13.9 9.0 3.1 10.6 4.9 9.3 4.6 6.4 11.3 10.8 5.8 13.9 5.8 13.7 11.6 0.9 0.3 0.1 0.3 0.4 0.2 0.4 0.3 0.3 0.1 0.3 0.5 0.4 1.0 0.1 0.5 0.4 0.4 0.1 4.0 3.9 4.3 5.9 4.1 3.9 3.9 3.7 3.9 3.7 3.9 4.4 36.5 22.4 33.7 47.7 26.0 19.1 22.8 13.5 30.7 19.5 25.6 21.0 28.2 10.0 35.1 11.0 25.0 8.4 36.6 22.1 15.6 8.8 3.9 22.1 34.8 25.4 16.2 14.1 87.4 9.4 5.7 20.8 19.9 36.9 56.3 30.1 23.9 16.3 11.3 18.5 58.2 17.0 24.4 13.9 14.2 6.3 12.8 22.2 8.8 35.6 21.3 12.7 22.6 58.3 106.9 12.7 13.1 17.3 29.5 19.3 19.2 8.8 21.2 27.8 26.3 28.8 21.5 15.5 20.6 25.0 18.5 11.4 30.8 22.0 18.5 26.4 NAALAD2 "GCPIII, NAALADASE2" ENSG00000077616 "N-acetylated alpha-linked acidic dipeptidase 2" Q9Y3Q0 11 90131515-90192894 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Carboxypeptidase, Dipeptidase, Hydrolase, Metalloprotease, Multifunctional enzyme, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pituitary gland: 19.9;testis: 13.9" "Group enriched" "Detected in many" 4 "Early spermatids: 39.7;Excitatory neurons: 109.3;Horizontal cells: 70.7;Inhibitory neurons: 110.2;Oligodendrocyte precursor cells: 153.8;Oligodendrocytes: 83.7" "Cancer enhanced" "Detected in some" "testis cancer: 1.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CACO-2: 19.2;SH-SY5Y: 6.1;SuSa: 4.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA060820, HPA065419" Approved Approved Nucleoplasm NA NA "Cluster 43: Testis - Unknown function" "Cluster 39: CACO-2 - Unknown function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA060820: AB_2684373, HPA065419: AB_2685487" "unprognostic (1.68e-1)" "unprognostic (2.66e-3)" "unprognostic (1.49e-1)" "unprognostic (4.52e-3)" "unprognostic (4.73e-3)" "unprognostic (2.97e-1)" "unprognostic (3.82e-3)" "unprognostic (1.77e-2)" "unprognostic (2.44e-1)" "unprognostic (2.30e-1)" "unprognostic (3.30e-2)" "unprognostic (8.00e-2)" "unprognostic (9.97e-4)" "unprognostic (1.52e-2)" "unprognostic (2.54e-1)" "unprognostic (1.63e-2)" "unprognostic (2.93e-1)" 3.8 10.0 2.3 0.4 3.3 0.1 3.3 1.5 5.3 10.3 0.0 1.9 0.2 4.1 1.9 0.8 3.4 1.2 2.1 2.4 2.8 1.5 0.9 2.1 0.4 3.6 3.5 7.4 0.7 0.1 19.9 3.5 3.4 3.2 0.6 3.5 1.1 1.2 1.1 0.7 1.3 1.1 2.0 2.6 1.2 13.9 3.0 0.1 1.4 0.7 0.1 2.2 4.0 4.2 0.1 0.2 1.8 0.1 0.5 0.1 2.2 0.1 0.1 0.1 0.0 19.2 0.7 0.3 0.2 0.0 0.3 0.3 1.3 0.0 0.0 0.0 0.3 1.9 0.4 1.7 0.2 0.1 0.1 1.9 0.0 0.0 0.0 0.5 0.4 0.2 0.1 0.0 0.0 0.0 0.3 0.3 1.8 0.5 0.2 0.3 0.0 0.2 0.0 0.0 0.2 6.1 0.0 0.2 0.0 4.3 0.2 0.4 2.4 0.1 1.4 0.3 0.3 1.0 0.3 0.3 0.6 0.3 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 2.3 3.3 1.5 5.3 2.4 2.8 3.6 3.5 3.4 2.0 3.0 4.2 2.6 0.0 0.0 3.3 0.1 0.3 0.1 0.0 0.0 17.3 0.0 0.0 2.4 1.5 0.6 0.0 0.0 1.2 0.1 0.0 0.0 0.1 39.7 0.8 13.7 1.2 0.0 0.0 109.3 0.0 0.6 7.5 1.1 0.6 0.0 1.7 0.7 0.2 0.3 70.7 110.2 0.0 0.0 7.2 0.4 17.7 11.1 0.5 0.0 12.2 0.0 8.4 0.0 153.8 83.7 0.0 0.0 14.7 0.4 0.4 0.0 0.1 0.0 2.4 0.0 6.4 4.6 0.6 11.3 0.4 0.0 0.8 0.2 19.4 0.2 0.1 NAALADL1 ENSG00000168060 "N-acetylated alpha-linked acidic dipeptidase like 1" Q9UQQ1 11 65044818-65058553 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 4 "intestine: 99.3" "Cell type enriched" "Detected in many" 11 "Proximal enterocytes: 588.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 182.0" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "ASC TERT1: 5.8;fHDF/TERT166: 7.8;HHSteC: 20.2;HSkMC: 13.5;SCLC-21H: 10.5" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA047123 Enhanced Uncertain Cytosol NA NA "Cluster 46: Basophils - DNA binding" "Cluster 9: Intestine - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 45: Enterocytes - Digestion" Cytosol "HPA047123: AB_2679942" "unprognostic (2.98e-2)" "unprognostic (2.06e-1)" "unprognostic (1.58e-1)" "unprognostic (8.76e-2)" "unprognostic (1.70e-1)" "unprognostic (1.28e-3)" "unprognostic (1.36e-1)" "unprognostic (1.40e-1)" "unprognostic (1.89e-2)" "unprognostic (1.38e-1)" "unprognostic (3.03e-1)" "unprognostic (2.18e-1)" "unprognostic (1.75e-4)" "unprognostic (2.10e-3)" "unprognostic (3.22e-2)" "unprognostic (1.45e-1)" "unprognostic (4.80e-2)" 13.9 3.2 4.4 6.6 4.1 21.1 12.1 4.7 6.0 23.5 7.0 18.4 19.8 18.8 4.6 7.3 15.2 9.4 10.5 3.9 4.1 7.4 2.6 10.9 10.9 4.7 4.3 16.6 2.3 2.0 6.0 2.3 4.6 13.8 7.1 1.9 4.9 11.5 2.7 5.4 99.3 10.5 4.6 15.3 8.2 8.7 4.4 3.4 5.7 4.1 6.9 12.7 14.5 4.0 0.0 0.0 0.1 0.2 0.5 5.8 1.0 2.3 0.0 2.8 1.3 0.0 0.0 0.1 0.0 7.8 0.0 0.0 0.0 0.2 0.1 0.9 0.4 0.0 0.2 3.5 20.2 0.0 0.0 13.5 0.0 2.7 0.0 0.1 3.6 0.1 0.0 0.3 0.0 0.2 0.2 0.7 0.0 0.1 0.1 0.1 0.0 1.0 0.2 0.0 10.5 0.4 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.2 0.8 0.0 0.1 0.1 182.0 21.2 35.9 29.6 14.6 15.8 25.7 23.8 14.8 16.3 29.8 27.0 15.0 3.7 80.2 8.8 0.7 45.2 24.6 4.4 4.1 4.7 6.0 3.9 4.1 4.7 4.3 4.6 4.6 4.4 4.0 19.1 0.0 0.0 0.0 8.0 3.6 3.4 5.6 6.2 2.0 0.8 9.1 1.8 1.5 0.4 0.0 0.0 0.2 9.8 31.3 3.9 0.1 0.8 0.4 5.8 11.1 1.2 2.5 0.3 0.8 0.3 11.4 1.1 0.2 19.7 4.3 16.8 0.4 2.8 10.1 0.4 21.0 2.0 5.6 5.7 2.6 11.8 5.2 16.0 1.0 17.3 12.2 41.2 1.0 0.1 0.2 50.0 18.0 1.1 0.5 588.6 0.5 0.5 0.9 0.0 8.3 11.1 1.6 3.5 1.3 3.3 0.4 11.1 3.9 11.8 0.4 NAALADL2 ENSG00000177694 "N-acetylated alpha-linked acidic dipeptidase like 2" Q58DX5 3 174438573-175810548 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 311.5;Inhibitory neurons: 135.1;Microglial cells: 155.5;Oligodendrocyte precursor cells: 468.0;Oligodendrocytes: 532.9" "Cancer enhanced" "Detected in many" "prostate cancer: 5.2" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC TERT1: 14.5;BJ hTERT+: 5.4;fHDF/TERT166: 6.4;WM-115: 5.9" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "HPA012413, HPA017425, CAB025586" Approved Enhanced Nucleoplasm NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 89: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 68: Oligodendrocytes - Mixed function" Nucleoplasm "CAB025586: , HPA012413: AB_1854274, HPA017425: AB_1854275" "unprognostic (7.28e-3)" "unprognostic (1.10e-1)" "unprognostic (6.28e-2)" "unprognostic (1.60e-1)" "unprognostic (2.56e-1)" "unprognostic (2.56e-1)" "unprognostic (2.29e-4)" "unprognostic (3.44e-3)" "unprognostic (5.70e-2)" "unprognostic (7.42e-2)" "unprognostic (7.85e-3)" "unprognostic (9.49e-2)" "unprognostic (3.66e-6)" "unprognostic (7.11e-2)" "unprognostic (1.48e-1)" "unprognostic (9.05e-2)" "unprognostic (2.22e-2)" 2.4 1.1 1.1 1.0 2.3 0.2 5.8 1.2 1.4 6.3 1.1 3.0 1.7 3.7 5.5 1.5 3.8 4.2 2.6 1.4 0.6 3.3 2.9 2.0 0.5 2.2 1.3 3.9 2.2 10.2 0.5 1.2 1.8 4.9 2.4 1.6 5.8 3.7 1.0 0.8 1.6 3.5 1.4 1.9 2.7 0.9 1.5 1.2 2.3 1.7 0.5 3.8 1.2 3.3 0.0 0.0 0.3 0.0 4.4 14.5 0.1 3.1 5.4 0.7 0.9 0.2 1.7 0.0 0.6 6.4 0.2 0.1 0.0 0.0 2.3 0.0 0.0 0.2 0.0 0.0 0.7 0.0 0.0 4.1 0.8 0.1 0.0 3.8 0.5 0.0 0.0 0.1 3.1 0.6 0.2 0.0 0.0 2.2 0.0 0.0 0.2 0.1 2.2 0.3 0.1 0.1 0.3 0.3 1.2 0.3 4.0 0.2 0.7 2.9 0.1 0.1 0.6 0.0 0.0 0.0 1.9 0.1 5.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4 0.0 0.0 1.1 2.3 1.2 1.4 1.4 0.6 2.2 1.3 1.8 1.4 1.5 3.3 5.1 0.0 11.5 311.5 0.1 2.3 8.9 2.7 1.2 7.7 35.1 13.7 3.0 12.8 9.1 12.9 12.5 19.6 0.3 11.1 7.9 10.1 74.9 23.7 8.7 2.8 9.0 2.7 113.4 2.5 1.4 15.0 23.9 30.2 4.5 3.4 2.9 4.5 1.8 0.0 135.1 2.6 10.2 0.3 3.0 39.6 15.2 1.1 3.6 155.5 0.0 6.7 0.0 468.0 532.9 3.6 4.4 12.0 0.0 13.6 13.2 2.4 21.9 6.2 0.0 23.4 4.9 3.2 2.8 5.3 1.8 12.3 0.8 5.7 16.4 16.0 NLN "AGTBP, KIAA1226" ENSG00000123213 Neurolysin Q9BYT8 5 65722205-65871725 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 52.8;Excitatory neurons: 58.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 5 "classical monocyte: 2.6;intermediate monocyte: 3.4;myeloid DC: 2.2;non-classical monocyte: 2.3" "Group enriched" "Detected in many" 5 "dendritic cells: 2.2;monocytes: 3.4" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031862 Approved Approved Mitochondria Yes No 64000 "Cluster 7: Monocytes - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 25: RPMI-8226 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Mitochondria "HPA031862: AB_10600827" "unprognostic (5.91e-3)" "unprognostic (4.52e-2)" "unprognostic (1.34e-3)" "unprognostic (4.37e-2)" "unprognostic (3.85e-1)" "unprognostic (1.45e-2)" "unprognostic (7.29e-3)" "unprognostic (3.24e-2)" "unprognostic (3.19e-1)" "unprognostic (3.58e-1)" "prognostic unfavorable (7.51e-4)" "unprognostic (1.27e-1)" "prognostic favorable (5.58e-7)" "unprognostic (1.52e-2)" "unprognostic (1.98e-1)" "unprognostic (1.29e-1)" "unprognostic (6.18e-3)" 2.2 1.0 3.8 2.4 3.9 1.5 3.7 2.9 5.3 1.8 1.6 3.6 1.1 2.7 2.4 2.5 1.5 1.2 2.6 3.8 3.6 3.9 9.9 1.7 1.7 3.9 3.4 1.8 2.5 1.5 0.9 2.4 4.0 2.6 3.2 2.5 1.9 1.1 8.9 2.8 2.7 2.7 3.3 1.3 4.0 1.1 3.9 0.9 2.7 6.5 2.0 2.7 1.5 4.8 13.3 12.5 7.2 12.0 9.0 15.3 14.5 13.1 5.5 7.6 8.2 7.2 7.7 18.8 16.1 15.8 15.1 10.3 9.5 20.2 13.1 5.6 6.4 5.2 8.7 18.5 7.7 12.0 3.0 11.7 10.8 10.5 12.4 6.3 21.7 8.3 11.4 3.9 16.5 10.2 8.3 10.8 22.2 6.7 3.6 9.6 15.3 29.9 12.6 5.9 22.3 11.5 10.6 10.7 11.0 19.4 12.9 14.1 12.5 5.0 5.9 7.4 10.0 3.3 7.1 8.2 7.7 23.2 7.7 0.1 2.6 0.1 0.1 3.4 0.1 0.4 0.2 0.1 2.2 0.4 0.3 0.2 0.3 0.5 2.3 0.1 0.0 1.0 3.8 3.9 2.9 5.3 3.8 3.6 3.9 3.4 4.0 3.3 3.9 4.8 5.9 6.4 2.8 19.6 4.0 5.7 9.0 6.2 8.6 2.4 10.1 8.9 14.5 7.2 8.5 12.9 4.2 5.3 0.6 52.8 5.9 17.8 0.3 7.4 12.9 8.3 1.8 9.0 58.9 14.5 14.0 7.1 20.4 20.9 15.2 16.2 4.6 32.4 28.8 5.0 32.2 5.8 6.1 22.9 8.9 0.4 4.4 13.5 1.8 5.6 17.9 13.1 2.1 22.6 44.5 30.2 35.9 2.2 4.9 16.5 32.3 22.4 3.1 4.7 0.0 19.7 8.1 2.1 5.2 15.3 5.3 2.9 2.3 15.8 8.2 6.1 NPEPL1 "bA261P9.2, FLJ11583" ENSG00000215440 "Aminopeptidase like 1" Q8NDH3 20 58689131-58719238 "Enzymes, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "basophil: 23.9;classical monocyte: 18.5;eosinophil: 7.2;intermediate monocyte: 13.0;myeloid DC: 11.4;neutrophil: 13.7;non-classical monocyte: 18.8" "Group enriched" "Detected in all" 5 "dendritic cells: 11.4;granulocytes: 23.9;monocytes: 18.8" "Cell line enhanced" "Detected in many" "MCF7: 106.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004986, CAB017025, HPA036356" Approved Approved Nucleoplasm,Cytosol NA NA 14000 "Cluster 14: Monocytes - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 52: Non-specific - Transcription" Nucleoplasm Cytosol "CAB004986: AB_426073, CAB017025: , HPA036356: AB_2675082" "unprognostic (1.68e-1)" "unprognostic (5.87e-3)" "unprognostic (8.28e-2)" "unprognostic (2.78e-1)" "unprognostic (5.42e-2)" "unprognostic (1.47e-3)" "unprognostic (2.86e-3)" "unprognostic (3.11e-2)" "unprognostic (4.14e-1)" "unprognostic (1.08e-2)" "unprognostic (1.62e-3)" "unprognostic (3.78e-2)" "prognostic unfavorable (1.87e-9)" "unprognostic (7.97e-2)" "unprognostic (1.64e-1)" "unprognostic (2.21e-1)" "prognostic favorable (5.73e-4)" 31.9 24.8 20.6 9.4 21.5 19.9 28.1 20.2 28.9 20.4 22.5 40.8 15.9 24.8 3.9 26.9 23.2 15.8 30.7 20.7 19.0 40.6 20.6 26.6 13.6 22.6 20.3 23.6 24.1 16.7 27.0 10.0 20.9 29.3 4.4 2.5 29.7 15.2 66.3 23.7 25.4 8.6 19.7 40.1 27.1 23.1 22.1 7.7 39.2 28.8 6.1 39.2 22.1 21.0 22.5 31.2 5.5 4.5 11.8 21.7 1.7 8.5 0.7 26.6 14.9 18.0 16.6 1.0 44.6 15.7 0.3 24.0 7.5 10.4 2.6 20.0 7.5 8.0 26.0 8.3 29.6 8.1 13.0 21.3 31.7 9.3 0.0 9.8 22.6 6.1 1.1 3.5 10.6 106.6 3.3 21.2 8.3 13.1 33.8 6.6 2.6 12.6 11.1 14.8 10.1 3.2 22.4 6.1 41.8 3.0 23.4 15.3 25.3 6.7 5.4 14.0 4.4 11.7 4.3 0.7 9.8 15.2 2.7 23.9 18.5 7.2 2.5 13.0 3.1 1.4 1.5 1.7 11.4 0.9 0.9 1.8 13.7 3.2 18.8 0.5 3.7 6.3 20.6 21.5 20.2 28.9 20.7 19.0 22.6 20.3 20.9 19.7 22.1 21.0 23.6 9.6 15.6 0.0 3.5 9.2 8.2 17.1 10.8 19.0 17.2 16.0 16.7 10.0 16.4 27.6 25.0 15.0 11.8 7.6 13.7 14.8 2.3 11.9 8.1 13.6 12.0 3.0 0.0 9.2 7.8 16.1 18.8 6.4 2.5 32.3 15.0 9.1 11.2 8.4 0.0 10.2 20.3 16.7 12.0 8.5 22.1 15.1 7.2 0.0 16.3 20.1 6.2 0.0 0.0 10.8 14.3 14.7 8.4 4.4 17.6 19.9 19.0 8.5 19.7 14.9 15.2 6.7 3.0 16.9 11.2 8.9 9.0 9.7 13.1 7.7 NPEPPS "MP100, PSA" ENSG00000141279 "Aminopeptidase puromycin sensitive" P55786 17 47522942-47624665 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021453, HPA045649" Uncertain Supported Cytosol No No 3000000 "Cluster 50: Neutrophils - Cellular senescence" "Cluster 59: Non-specific - Translation" "Cluster 6: T47d - Mammary gland" "Cluster 44: Endometrium - Transcription" Cytosol "HPA021453: AB_2670709, HPA045649: AB_2679406" "unprognostic (1.63e-1)" "unprognostic (3.15e-2)" "prognostic favorable (3.39e-5)" "unprognostic (2.66e-2)" "unprognostic (1.53e-1)" "unprognostic (5.92e-2)" "prognostic unfavorable (3.67e-5)" "unprognostic (3.84e-2)" "unprognostic (1.22e-1)" "unprognostic (1.77e-1)" "unprognostic (3.85e-2)" "unprognostic (3.63e-2)" "unprognostic (1.93e-1)" "unprognostic (8.55e-2)" "unprognostic (1.52e-1)" "unprognostic (1.23e-2)" "unprognostic (1.07e-1)" 32.2 50.0 30.6 19.4 34.8 7.3 30.1 30.7 41.1 41.5 26.1 38.6 20.3 32.0 11.1 92.2 32.6 22.2 30.6 32.9 30.3 30.9 23.8 30.5 18.4 35.7 34.2 39.9 34.2 30.1 26.7 27.3 35.7 27.9 27.4 21.0 44.4 20.6 114.5 47.3 37.1 33.7 26.1 31.9 33.4 19.2 34.2 26.4 26.8 86.6 27.5 34.8 58.2 30.5 105.7 81.7 67.3 49.4 92.1 81.9 147.5 47.5 63.9 70.4 66.5 55.7 100.6 68.4 76.1 69.2 70.1 62.0 83.7 44.8 108.7 31.5 73.2 76.5 62.3 59.2 48.3 48.8 46.6 61.5 41.1 52.7 26.8 99.2 77.5 20.1 72.5 30.7 109.9 37.2 66.0 34.7 47.8 74.4 68.0 50.5 107.2 60.1 82.6 81.0 59.7 46.0 59.1 34.9 44.7 122.0 256.3 35.5 88.6 44.1 35.2 72.5 34.9 63.7 81.1 39.9 64.8 25.3 33.5 14.2 9.9 12.4 8.8 7.9 9.6 7.7 7.2 9.2 9.7 6.9 6.3 7.8 28.4 8.8 9.1 10.1 8.8 6.3 30.6 34.8 30.7 41.1 32.9 30.3 35.7 34.2 35.7 26.1 34.2 30.5 32.0 83.3 59.1 68.6 44.7 77.9 68.9 40.2 109.8 144.6 76.6 33.8 60.3 55.8 53.6 42.3 268.9 81.2 35.6 87.0 27.4 69.3 34.2 95.2 80.9 45.4 44.3 44.6 98.0 54.4 74.4 66.0 58.1 158.1 41.7 62.7 45.7 32.5 40.5 112.7 95.3 44.1 38.7 51.0 62.1 50.8 52.8 45.4 58.7 37.5 51.5 38.7 38.1 69.4 74.9 103.4 61.6 50.0 52.5 106.2 58.7 46.5 63.8 153.3 78.9 53.8 53.5 52.0 28.6 101.6 102.6 104.7 40.4 45.9 51.5 195.2 NRDC "hNRD1, hNRD2, NRD1" ENSG00000078618 "Nardilysin convertase" O43847 1 51789191-51878937 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 267.3" "Group enriched" "Detected in many" 9 "Early spermatids: 597.7;Late spermatids: 1672.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA053661 Approved Nucleoplasm NA NA 58000 "Cluster 5: Granulocytes - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 31: Spermatids - Spermatogenesis" Nucleoplasm "HPA053661: AB_2682221" "unprognostic (1.22e-1)" "unprognostic (6.52e-2)" "unprognostic (2.14e-2)" "unprognostic (5.62e-2)" "unprognostic (2.61e-1)" "unprognostic (3.25e-2)" "prognostic unfavorable (5.49e-6)" "unprognostic (1.42e-1)" "unprognostic (4.17e-2)" "unprognostic (1.67e-1)" "unprognostic (5.86e-2)" "unprognostic (1.00e-1)" "prognostic unfavorable (2.12e-9)" "unprognostic (2.75e-1)" "unprognostic (2.35e-2)" "unprognostic (9.54e-2)" "unprognostic (5.53e-3)" 48.2 36.8 33.3 48.2 33.9 48.5 34.2 33.6 42.3 31.1 37.2 32.5 32.3 31.1 20.2 40.4 29.7 31.0 58.5 34.4 35.5 26.5 55.7 34.3 43.8 35.2 34.6 32.6 40.1 60.9 32.8 40.2 37.8 38.6 35.3 48.1 28.7 30.5 267.3 51.4 31.4 38.4 33.6 40.9 35.2 95.6 36.5 54.9 33.1 182.0 46.7 36.5 28.4 38.1 166.8 91.0 94.2 133.4 98.9 145.5 106.8 165.6 143.9 116.6 123.5 65.6 65.3 108.3 84.7 128.4 157.6 95.1 136.5 127.9 156.2 127.7 66.1 129.5 125.4 62.9 97.9 114.4 95.4 117.2 102.1 169.7 160.0 105.0 125.7 113.1 174.7 71.7 153.4 62.9 105.0 45.2 161.5 71.8 97.4 101.6 106.4 122.6 92.8 94.7 86.5 65.2 148.0 124.8 94.5 185.7 79.3 152.5 102.4 103.8 94.2 114.2 146.0 103.9 168.4 100.1 120.8 146.6 120.1 44.5 33.8 50.0 23.2 35.1 23.3 23.2 21.5 26.0 33.7 15.6 20.9 22.7 67.8 29.8 28.3 27.5 26.9 33.1 33.3 33.9 33.6 42.3 34.4 35.5 35.2 34.6 37.8 33.6 36.5 38.1 43.5 35.3 69.0 0.0 58.9 0.0 46.3 0.0 38.7 73.3 38.2 31.0 0.0 28.6 34.7 27.6 81.3 56.8 94.3 11.1 31.3 48.1 597.7 63.1 78.8 39.4 18.2 85.8 0.0 64.0 45.5 40.1 56.6 55.4 35.3 74.6 30.4 59.9 44.3 62.2 0.0 19.5 0.0 44.6 0.0 1672.1 66.2 72.5 0.0 0.0 70.3 45.9 55.6 0.0 0.0 57.6 13.7 59.0 126.1 41.9 30.1 19.6 59.0 71.8 59.2 64.5 38.2 39.0 28.1 57.7 0.0 82.5 52.8 65.9 21.6 42.3 OMA1 "FLJ33782, MPRP-1, YKR087C, ZMPOMA1" ENSG00000162600 "OMA1 zinc metallopeptidase" Q96E52 1 58415384-58546802 "Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 106.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA055120 Approved Approved Nucleoplasm,Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Nucleoplasm, Mitochondria" "HPA055120: AB_2682702" "prognostic favorable (1.63e-4)" "unprognostic (2.67e-2)" "prognostic favorable (7.70e-4)" "unprognostic (1.60e-3)" "unprognostic (1.61e-1)" "unprognostic (9.57e-2)" "unprognostic (3.94e-3)" "prognostic favorable (8.52e-4)" "unprognostic (8.22e-3)" "unprognostic (6.91e-2)" "unprognostic (4.10e-2)" "unprognostic (1.40e-1)" "unprognostic (9.54e-3)" "unprognostic (2.52e-2)" "unprognostic (3.93e-2)" "unprognostic (1.74e-2)" "unprognostic (5.24e-3)" 11.4 18.7 15.1 14.0 22.8 12.8 19.7 23.1 14.9 16.7 14.9 20.8 14.9 13.5 17.8 13.3 19.4 15.1 19.8 13.0 19.5 28.4 31.1 11.9 23.4 18.8 17.9 13.5 17.9 18.1 10.4 11.5 21.1 20.8 20.0 20.5 19.5 16.7 28.2 12.8 14.2 12.4 15.6 20.2 17.3 8.2 18.3 20.2 20.1 29.9 21.5 14.8 10.5 27.3 31.2 13.0 8.3 7.9 41.7 39.0 24.6 12.7 13.9 10.9 13.7 4.0 18.7 69.8 26.3 13.1 37.8 31.2 31.1 31.3 13.3 55.1 17.9 22.0 10.4 16.1 20.3 54.3 14.7 37.3 33.6 10.4 22.4 24.1 9.3 34.3 42.7 20.1 29.2 19.5 18.0 19.4 12.4 47.4 28.5 22.1 27.7 29.1 23.6 20.5 8.7 4.3 26.0 41.9 37.6 38.4 19.5 20.1 5.4 5.6 10.8 27.8 13.5 16.3 23.4 46.2 16.8 42.2 14.1 20.1 14.4 32.1 19.4 24.1 25.6 35.6 23.7 23.1 15.4 35.0 33.9 31.5 17.2 30.9 35.1 8.2 23.6 15.9 15.1 22.8 23.1 14.9 13.0 19.5 18.8 17.9 21.1 15.6 18.3 27.3 8.4 19.2 11.5 37.9 25.7 6.0 18.2 35.6 13.6 7.8 15.0 12.3 27.2 8.6 33.0 25.8 12.5 22.9 14.4 8.4 25.4 11.2 5.8 31.6 10.8 6.3 6.0 15.6 18.3 5.5 10.0 12.0 5.6 18.4 6.3 10.9 6.4 18.7 15.8 1.7 31.7 17.7 36.7 10.1 9.7 12.7 9.9 12.9 7.2 29.0 11.3 10.9 15.5 52.8 106.5 3.8 10.9 8.6 16.8 12.3 8.5 32.4 63.1 20.5 6.6 12.0 8.6 14.3 13.6 17.3 6.8 18.3 20.7 17.1 14.6 17.1 PA2G4 ENSG00000170515 "Proliferation-associated 2G4" Q9UQ80 12 56104537-56113910 "Enzymes, Plasma proteins, Predicted intracellular proteins" "rRNA processing, Transcription, Transcription regulation, Translation regulation" "Repressor, Ribonucleoprotein, RNA-binding" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011711, CAB012428, HPA016484" Supported Approved Cytosol NA NA 2300000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Cytosol "CAB011711: AB_732060, CAB012428: , HPA016484: AB_1854912" "unprognostic (5.53e-2)" "unprognostic (1.06e-1)" "unprognostic (2.35e-2)" "unprognostic (2.34e-2)" "unprognostic (3.87e-1)" "unprognostic (6.03e-3)" "prognostic unfavorable (6.31e-7)" "unprognostic (4.25e-3)" "unprognostic (2.77e-1)" "unprognostic (3.79e-3)" "unprognostic (2.29e-2)" "unprognostic (1.30e-2)" "prognostic unfavorable (4.59e-7)" "unprognostic (1.17e-1)" "unprognostic (2.01e-1)" "unprognostic (1.32e-1)" "unprognostic (4.67e-2)" 78.4 59.6 46.7 89.3 50.4 132.9 76.2 50.7 58.0 64.8 43.0 78.7 74.1 64.7 48.2 132.5 64.7 43.7 76.9 48.6 51.8 62.1 72.8 62.5 96.6 49.4 48.3 71.2 75.1 83.7 36.3 69.2 51.0 53.2 90.5 38.3 63.9 55.4 144.0 106.1 69.7 68.4 49.8 61.2 65.5 63.1 48.9 123.4 61.4 92.5 120.7 105.3 76.9 57.2 429.6 374.8 248.9 275.5 112.5 169.8 499.6 441.3 209.7 530.9 293.8 464.7 307.5 850.8 291.2 209.6 155.9 343.5 574.2 493.1 510.9 243.9 517.6 659.1 242.5 400.4 219.7 898.8 232.4 172.5 247.2 460.2 410.8 218.1 327.3 292.0 812.8 380.7 294.7 383.5 700.8 496.2 410.9 264.5 460.9 569.3 449.8 577.2 272.0 315.7 372.8 225.6 290.5 451.6 275.0 183.1 488.7 343.5 264.8 256.3 364.7 300.3 495.5 234.4 345.1 822.1 232.3 532.6 340.9 34.3 87.0 54.6 129.9 96.0 174.7 98.0 136.8 141.3 102.1 81.3 129.7 131.2 13.8 151.5 82.0 98.6 170.9 155.9 46.7 50.4 50.7 58.0 48.6 51.8 49.4 48.3 51.0 49.8 48.9 57.2 135.7 54.5 91.2 9.8 136.3 368.5 244.7 187.4 224.8 56.2 151.9 165.7 37.3 118.7 161.3 130.6 18.8 232.0 163.1 123.4 193.7 235.8 530.6 127.1 218.4 154.2 93.3 552.1 12.8 249.1 321.7 139.5 112.7 142.2 170.9 103.7 107.8 197.5 208.6 33.7 13.0 159.0 99.7 124.2 127.8 238.9 132.0 126.2 129.9 6.5 155.4 117.1 178.2 10.6 14.8 269.3 100.8 126.7 163.5 360.7 118.6 264.7 103.6 48.8 144.7 188.1 191.7 344.6 110.9 295.2 362.7 193.5 176.2 132.2 254.1 242.7 PAPPA "ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1" ENSG00000182752 "Pappalysin 1" Q13219 9 116153791-116402321 "Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "placenta: 72.3" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 92.2;Collecting duct cells: 165.5;Endometrial stromal cells: 101.3;Proximal tubular cells: 51.5" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 50.0;ASC TERT1: 37.8;HSkMC: 137.4;U-138 MG: 36.3" "Low region specificity" "Detected in single" "Low region specificity" "Detected in many" "HPA001667, CAB016724" Enhanced "Secreted in female reproductive system" NA NA 78000000 "Cluster 28: Placenta - Pregnancy" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 36: Stromal cells - Cell proliferation" "CAB016724: , HPA001667: AB_1854960" "unprognostic (3.25e-1)" "unprognostic (6.18e-6)" "unprognostic (2.47e-1)" "unprognostic (6.49e-2)" "unprognostic (2.01e-2)" "unprognostic (1.14e-1)" "unprognostic (1.13e-1)" "unprognostic (5.42e-3)" "unprognostic (5.44e-2)" "unprognostic (3.87e-2)" "unprognostic (6.87e-3)" "unprognostic (8.25e-2)" "unprognostic (8.00e-3)" "unprognostic (2.37e-3)" "unprognostic (2.48e-1)" "unprognostic (4.01e-1)" "unprognostic (1.02e-3)" 4.1 1.5 0.7 1.8 0.2 0.0 0.8 0.5 0.9 4.2 2.2 2.0 0.3 3.9 0.6 2.5 3.1 2.0 2.6 0.3 1.6 3.8 0.3 1.9 1.2 2.5 2.5 2.5 0.8 9.1 0.4 72.3 2.0 1.1 1.5 1.0 0.4 2.1 0.3 0.9 0.9 4.2 0.4 0.3 1.1 0.8 1.6 0.8 1.0 1.4 1.0 4.5 2.4 1.3 0.0 14.9 22.3 0.0 50.0 37.8 0.0 12.2 21.4 3.3 5.6 0.0 0.0 0.0 0.0 8.6 1.1 1.7 0.0 0.0 15.6 0.0 0.0 2.6 12.8 0.1 24.3 0.0 0.0 137.4 0.0 16.4 1.9 26.9 0.1 0.0 0.5 0.0 3.8 0.0 0.0 0.0 6.5 0.0 0.0 0.0 0.6 0.0 0.6 0.1 0.1 1.2 1.8 0.0 0.0 6.8 0.0 0.0 28.9 36.3 1.8 1.0 1.4 0.0 0.0 0.0 25.8 0.0 11.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.2 0.5 0.9 0.3 1.6 2.5 2.5 2.0 0.4 1.6 1.3 0.2 0.0 1.5 3.9 1.0 2.9 0.2 4.0 92.2 17.6 0.8 0.4 3.4 0.0 1.6 165.5 12.5 0.5 0.1 0.1 9.8 5.9 20.1 4.7 101.3 1.4 0.0 0.0 10.0 0.9 19.5 31.8 0.5 2.6 1.3 10.4 4.6 0.1 0.4 0.0 19.6 0.0 0.0 0.0 5.8 17.9 14.3 1.0 1.8 7.5 0.0 2.5 1.0 15.1 2.9 0.3 0.0 8.6 1.2 1.2 0.2 51.5 1.6 2.9 0.0 3.3 10.9 2.2 0.6 19.7 1.1 14.0 1.3 0.2 0.1 0.3 PAPPA2 "PAPP-A2, PAPPE, PLAC3" ENSG00000116183 "Pappalysin 2" Q9BXP8 1 176463171-176845601 "Enzymes, Predicted membrane proteins, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 9 "placenta: 56.8" "Cell type enhanced" "Detected in some" "Enteroendocrine cells: 140.7;Extravillous trophoblasts: 71.9;Muller glia cells: 41.4;Oligodendrocytes: 37.6;Syncytiotrophoblasts: 74.0" "Cancer enhanced" "Detected in some" "pancreatic cancer: 1.8;renal cancer: 1.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "U-87 MG: 19.8" "Low region specificity" "Detected in some" "Region enhanced" "Detected in some" "cerebellum: 5.6" "HPA018412, HPA018430" Enhanced Approved "Endoplasmic reticulum,Vesicles" "Secreted in female reproductive system" NA NA 2000000 "Cluster 28: Placenta - Pregnancy" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 17: Intestinal endocrine cells - Hormone signaling" "Endoplasmic reticulum, Vesicles" "HPA018412: AB_1854962, HPA018430: AB_1854961" "unprognostic (2.90e-1)" "unprognostic (1.58e-1)" "unprognostic (1.07e-1)" "unprognostic (3.61e-2)" "unprognostic (9.04e-2)" "unprognostic (1.60e-3)" "unprognostic (1.36e-1)" "unprognostic (2.45e-1)" "unprognostic (1.00e-2)" "unprognostic (3.54e-2)" "unprognostic (1.29e-2)" "unprognostic (4.39e-2)" "unprognostic (2.85e-2)" "unprognostic (1.52e-4)" "unprognostic (1.85e-1)" "unprognostic (8.18e-4)" "unprognostic (4.35e-2)" 0.6 0.0 0.5 0.3 0.3 0.0 2.5 0.3 0.4 6.6 0.0 0.6 0.0 0.6 0.3 0.0 0.2 1.8 0.3 0.5 0.2 6.3 0.6 0.1 0.0 0.5 0.5 0.0 2.5 0.0 1.1 56.8 0.6 0.2 0.5 3.7 0.1 0.6 0.0 0.1 0.2 0.5 0.4 0.0 1.6 0.4 0.3 0.0 0.5 0.0 0.0 0.3 0.2 0.4 0.0 0.0 0.0 0.0 0.2 0.7 0.0 0.1 0.3 0.0 0.5 0.0 0.0 0.0 0.1 0.8 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 1.2 4.3 2.1 3.5 0.9 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.7 0.5 0.5 0.2 0.0 0.0 0.1 0.7 0.0 0.0 0.3 1.6 1.3 0.1 0.6 0.3 0.4 0.0 19.8 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.3 0.3 0.4 0.5 0.2 0.5 0.5 0.6 0.4 0.3 0.4 0.0 0.0 0.0 26.1 0.0 0.0 0.0 0.0 0.0 6.1 0.0 0.1 0.8 0.0 0.0 5.5 0.0 1.5 0.0 0.1 11.7 0.0 2.6 0.2 0.1 0.3 140.7 0.0 16.3 0.2 71.9 0.8 0.0 0.0 0.0 0.0 0.0 0.6 1.3 0.0 10.8 0.2 0.0 0.0 0.0 1.9 11.5 0.0 0.0 2.8 0.0 41.4 0.0 5.0 37.6 0.8 0.0 10.9 0.0 0.0 0.0 0.5 0.0 2.4 6.6 0.0 1.2 1.3 2.2 0.0 0.0 74.0 0.0 0.0 0.2 0.1 PEPD ENSG00000124299 "Peptidase D" P12955 19 33386950-33521791 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Collagen degradation" "Dipeptidase, Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 209.5;kidney: 277.7" "Group enriched" "Detected in all" 4 "Proximal enterocytes: 833.0;Proximal tubular cells: 1278.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015599, HPA072045" Enhanced Approved Nucleoplasm NA NA 860000000 "Cluster 39: Non-specific - mRNA processing" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "HPA015599: AB_1855192, HPA072045: AB_2732194" "unprognostic (1.39e-1)" "unprognostic (2.62e-2)" "unprognostic (2.27e-1)" "unprognostic (4.01e-2)" "unprognostic (2.98e-1)" "unprognostic (6.77e-2)" "unprognostic (2.82e-1)" "unprognostic (3.64e-2)" "unprognostic (3.96e-1)" "unprognostic (5.10e-2)" "unprognostic (1.11e-2)" "unprognostic (1.99e-1)" "prognostic favorable (6.50e-9)" "unprognostic (4.38e-2)" "unprognostic (1.99e-1)" "unprognostic (1.65e-1)" "unprognostic (1.29e-1)" 53.2 56.0 28.5 26.9 35.5 14.3 43.6 35.6 30.5 36.9 33.5 44.2 180.5 49.7 9.9 42.8 34.2 31.2 24.3 28.7 30.9 277.7 117.8 38.1 30.7 36.2 30.8 35.9 27.1 29.3 42.5 21.9 36.3 23.6 14.8 11.8 33.6 22.9 35.6 43.1 209.5 24.5 34.6 38.2 33.6 18.3 33.4 20.8 37.0 23.2 21.3 40.1 28.2 43.4 43.2 118.7 26.4 53.1 114.9 44.9 80.6 37.4 65.3 45.6 52.7 104.7 34.2 18.8 53.5 73.2 33.9 11.2 39.5 28.5 23.4 51.3 50.4 107.7 24.6 108.3 91.6 29.6 128.8 63.6 29.0 38.2 18.3 27.8 56.4 34.4 22.7 49.4 44.2 54.3 19.0 11.7 46.2 79.6 48.8 45.3 41.0 51.2 39.4 108.8 40.3 106.4 64.2 31.3 62.5 18.2 25.1 36.3 56.6 48.3 46.6 62.3 41.8 45.2 59.1 13.1 49.5 48.2 65.8 113.7 117.2 8.3 75.5 123.6 65.5 49.6 74.0 69.8 100.6 50.5 47.1 55.6 6.1 55.6 92.5 31.0 76.1 119.6 28.5 35.5 35.6 30.5 28.7 30.9 36.2 30.8 36.3 34.6 33.4 43.4 56.9 22.4 27.4 11.4 29.0 19.4 32.9 36.0 11.4 33.3 16.2 24.4 13.3 52.9 23.8 73.5 4.2 21.4 32.6 17.6 197.6 77.2 8.0 15.0 20.1 50.7 17.3 25.4 19.9 44.2 67.3 38.6 18.3 13.0 57.6 41.9 52.8 180.3 227.2 62.2 14.9 35.6 30.5 59.7 40.9 13.2 49.4 75.3 67.6 15.9 102.2 73.6 34.0 21.6 24.3 33.8 79.3 60.5 31.5 22.9 833.0 1278.3 27.1 33.7 39.5 37.0 43.1 10.2 44.5 34.3 20.3 30.4 33.7 48.7 44.6 22.2 PHEX "HPDR, HPDR1, HYP, HYP1, PEX, XLH" ENSG00000102174 "Phosphate regulating endopeptidase homolog X-linked" P78562 X 22032325-22251310 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins" Biomineralization "Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "lung: 2.7" "Group enriched" "Detected in many" 5 "dendritic cells: 45.3;Granulosa cells: 161.7" "Cancer enriched" "Detected in some" 4 "thyroid cancer: 5.9" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 37 "plasmacytoid DC: 4.8" "Lineage enriched" "Detected in single" 37 "dendritic cells: 4.8" "Cell line enhanced" "Detected in some" "HBEC3-KT: 3.7;HUVEC TERT2: 2.8;PC-3: 3.0;TIME: 3.1;U-87 MG: 6.5;WM-115: 2.8" "Low region specificity" "Detected in some" "Low region specificity" "Detected in some" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 40: Granulosa cells - Unknown function" "unprognostic (2.01e-2)" "unprognostic (2.69e-1)" "unprognostic (2.43e-1)" "unprognostic (1.05e-3)" "unprognostic (1.22e-1)" "unprognostic (3.04e-2)" "unprognostic (2.25e-3)" "unprognostic (1.23e-1)" "unprognostic (1.87e-1)" "unprognostic (1.21e-2)" "unprognostic (7.53e-2)" "unprognostic (7.45e-2)" "unprognostic (9.84e-8)" "unprognostic (1.18e-1)" "unprognostic (1.58e-1)" "prognostic favorable (2.51e-4)" "unprognostic (7.68e-2)" 0.0 0.0 1.0 0.5 1.0 0.0 0.7 1.8 0.7 0.9 0.4 0.3 0.5 2.0 0.1 0.2 0.1 0.9 0.0 0.8 2.2 0.1 0.0 2.7 1.5 1.6 1.6 1.6 0.0 0.0 0.2 0.1 1.9 0.6 0.0 0.3 0.2 0.4 0.0 0.1 0.6 1.5 1.8 0.4 0.0 0.1 1.3 0.3 1.0 0.3 0.9 0.2 0.3 2.1 0.2 0.5 0.1 0.0 0.0 0.2 0.0 0.0 0.1 0.1 0.1 0.8 0.0 0.1 0.8 0.0 0.1 0.1 0.0 3.7 0.2 0.0 0.1 0.1 0.3 0.0 0.0 0.0 0.1 1.3 0.7 0.7 2.1 0.1 2.8 0.2 0.0 0.3 0.3 0.0 0.0 0.1 0.0 0.0 3.0 0.0 0.6 0.0 0.4 0.1 0.1 0.1 0.2 1.5 0.5 0.4 1.8 0.0 3.1 0.6 0.1 0.4 0.5 0.0 0.0 0.0 6.5 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 4.8 0.0 0.0 1.0 1.0 1.8 0.7 0.8 2.2 1.6 1.6 1.9 1.8 1.3 2.1 0.0 0.0 0.0 3.9 0.8 0.0 5.8 2.3 0.0 0.4 3.0 1.8 0.5 0.0 1.6 0.0 0.0 0.2 45.3 0.7 0.0 0.9 0.4 1.3 1.4 0.2 0.0 0.0 2.2 1.2 0.1 2.9 0.0 1.8 0.0 161.7 0.0 0.0 0.0 16.8 1.9 0.5 4.1 0.0 0.4 0.3 1.8 1.2 1.8 0.0 0.0 0.6 0.0 1.5 0.5 0.8 0.0 0.0 0.3 1.8 8.2 0.9 4.5 0.5 0.0 2.1 2.6 0.1 0.4 0.1 0.1 0.8 0.4 18.9 0.4 3.3 PITRM1 "hMP1, KIAA1104, MP1, PreP" ENSG00000107959 "Pitrilysin metallopeptidase 1" Q5JRX3 10 3137728-3172841 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 186.1;Late spermatids: 98.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006753, HPA006754" Enhanced Supported Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 59: Non-specific - Translation" "Cluster 18: U-2197 - ECM organization" "Cluster 34: Spermatids - Unknown function" Mitochondria "HPA006753: AB_1079624, HPA006754: AB_1079623" "unprognostic (1.83e-3)" "unprognostic (7.01e-3)" "unprognostic (2.19e-1)" "unprognostic (1.69e-1)" "unprognostic (3.20e-2)" "unprognostic (6.67e-2)" "unprognostic (1.55e-1)" "unprognostic (1.78e-1)" "unprognostic (6.31e-2)" "unprognostic (3.41e-1)" "unprognostic (1.00e-2)" "unprognostic (3.32e-1)" "unprognostic (7.10e-2)" "unprognostic (3.99e-1)" "unprognostic (5.80e-2)" "unprognostic (4.76e-3)" "unprognostic (2.08e-2)" 40.8 64.9 22.7 19.1 24.9 26.0 36.9 23.8 34.2 40.9 22.9 40.9 19.6 40.5 23.8 38.4 38.0 18.3 60.2 25.2 24.5 50.5 44.9 40.4 21.0 25.3 26.0 54.4 41.1 33.3 42.3 17.0 26.0 42.6 22.1 49.6 41.3 22.1 94.9 39.2 32.7 25.8 21.0 30.4 37.0 43.6 26.1 42.4 41.7 59.6 21.7 43.6 38.4 28.5 81.8 67.2 21.7 31.7 62.1 67.6 22.3 125.9 51.0 92.5 49.1 55.5 45.5 38.5 39.5 70.7 33.2 55.8 37.8 82.4 74.3 72.3 55.0 61.1 42.9 39.2 36.2 21.8 62.3 50.4 57.0 103.5 55.8 55.4 81.2 56.3 60.1 44.5 115.7 67.1 59.6 14.0 15.0 97.9 71.0 27.5 34.1 54.0 67.9 54.8 29.4 16.4 95.9 57.5 46.6 35.8 67.2 23.9 114.5 63.7 17.2 160.5 47.8 36.1 48.6 41.7 108.8 38.2 31.5 3.1 6.9 1.5 10.3 8.8 10.5 10.4 9.5 10.9 13.3 5.3 9.7 11.1 0.3 13.7 11.9 5.3 12.6 8.5 22.7 24.9 23.8 34.2 25.2 24.5 25.3 26.0 26.0 21.0 26.1 28.5 12.2 28.9 29.0 13.4 9.3 6.8 17.6 11.1 6.2 13.1 10.7 12.2 44.9 8.6 23.5 3.7 20.9 13.4 7.9 12.4 7.9 18.2 186.1 14.5 14.6 14.0 18.0 10.7 18.4 29.2 20.0 14.7 16.8 23.1 14.5 18.0 7.1 16.3 14.8 6.7 17.9 12.7 20.3 10.1 6.3 98.7 17.1 10.0 19.6 6.5 9.9 7.1 4.1 11.1 14.7 34.8 10.0 14.7 13.7 23.9 10.6 8.5 19.1 19.7 6.6 16.9 15.3 28.1 21.6 17.0 5.7 13.5 10.1 30.4 12.9 17.7 PM20D1 "Cps1, FLJ32569" ENSG00000162877 "Peptidase M20 domain containing 1" Q6GTS8 1 205828025-205850132 "Enzymes, Predicted secreted proteins" "Hydrolase, Lyase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 9 "pancreas: 78.0;skin 1: 33.8" "Cell type enhanced" "Detected in some" "Exocrine glandular cells: 20.9;Gastric mucus-secreting cells: 7.1;Proximal tubular cells: 7.1" "Cancer enriched" "Detected in some" 32 "urothelial cancer: 30.2" "Not detected" "Not detected" "Immune cell enhanced" "Detected in some" "T-reg: 2.2" "Lineage enriched" "Detected in single" 6 "T-cells: 2.2" "Cell line enriched" "Detected in single" 9 "Karpas-707: 1.9" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "Secreted to digestive system" NA NA 3300000 "Cluster 35: T-regs - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 2: Karpas-707 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "unprognostic (1.16e-1)" "unprognostic (1.95e-1)" "unprognostic (1.30e-1)" "unprognostic (4.07e-2)" "unprognostic (4.83e-1)" "unprognostic (4.08e-3)" "unprognostic (1.17e-3)" "unprognostic (3.11e-1)" "unprognostic (1.20e-1)" "unprognostic (5.50e-2)" "unprognostic (5.81e-2)" "unprognostic (4.57e-2)" "unprognostic (7.79e-3)" "unprognostic (9.77e-2)" "unprognostic (1.45e-1)" "unprognostic (2.48e-1)" "unprognostic (1.68e-2)" 0.8 0.0 0.2 0.1 0.2 0.0 1.2 0.0 0.3 0.1 1.2 0.1 0.1 0.1 0.5 0.0 0.4 0.0 0.3 0.2 0.3 6.3 0.2 0.2 1.1 0.3 0.3 0.3 78.0 0.0 0.0 0.1 0.3 0.0 0.1 0.3 0.0 0.0 0.0 33.8 0.1 0.0 0.2 1.0 2.9 0.0 0.3 0.1 0.1 0.0 0.4 2.2 0.1 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.4 0.3 0.0 0.5 0.1 0.4 1.3 0.0 0.1 0.1 0.4 0.0 0.0 0.1 0.0 2.2 0.3 0.2 0.2 0.0 0.3 0.2 0.3 0.3 0.3 0.3 0.2 0.3 0.3 0.8 0.0 0.0 1.6 1.1 0.0 0.0 0.0 0.6 0.5 0.0 0.0 1.5 0.0 0.0 0.0 2.1 0.0 0.9 0.1 0.0 0.1 0.0 0.1 0.1 0.3 0.0 0.4 3.2 20.9 0.3 0.5 7.1 0.0 0.0 0.0 0.7 0.3 0.1 0.0 3.5 0.2 0.0 1.3 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 1.0 1.5 1.5 0.6 0.0 0.0 1.8 0.2 0.0 7.1 0.0 0.8 0.0 0.2 0.2 0.1 0.1 0.0 0.1 0.0 0.9 2.4 0.0 0.1 PM20D2 "ACY1L2, bA63L7.3" ENSG00000146281 "Peptidase M20 domain containing 2" Q8IYS1 6 89146055-89165565 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "Daudi: 88.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030325, HPA030326, HPA030327" Approved Enhanced Nucleoplasm NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 32: U-937 - Innate immune response" "Cluster 37: Myocytes - Muscle contraction" Nucleoplasm "HPA030325: , HPA030326: AB_2673429, HPA030327: AB_10603129" "unprognostic (3.60e-2)" "unprognostic (1.40e-1)" "unprognostic (6.36e-2)" "unprognostic (3.18e-3)" "unprognostic (3.22e-2)" "unprognostic (2.73e-1)" "unprognostic (1.13e-3)" "unprognostic (8.60e-2)" "unprognostic (1.04e-1)" "unprognostic (5.86e-2)" "unprognostic (2.27e-2)" "unprognostic (1.04e-1)" "unprognostic (9.99e-2)" "unprognostic (6.84e-2)" "unprognostic (1.28e-1)" "unprognostic (1.32e-1)" "unprognostic (1.31e-1)" 5.4 6.0 4.5 8.6 4.8 9.2 9.4 7.3 5.2 9.4 10.1 13.6 8.8 11.8 8.2 8.9 12.9 6.5 8.2 4.5 6.1 9.2 4.8 4.9 11.2 4.6 4.0 22.3 10.7 9.2 8.2 4.8 3.3 25.4 10.1 14.1 7.8 8.5 29.1 12.6 8.9 10.4 3.4 6.1 8.5 3.0 5.9 13.6 12.5 16.3 10.8 10.9 8.1 3.9 30.7 13.4 11.8 18.3 3.8 2.3 0.8 15.1 15.0 22.1 28.2 15.7 14.6 88.3 18.0 3.3 18.8 11.5 24.3 12.1 49.9 27.8 30.8 18.0 8.0 14.9 4.2 52.4 13.9 3.8 8.8 8.4 17.7 18.0 5.4 26.2 7.0 46.3 6.9 4.7 33.3 41.3 4.8 26.4 13.2 54.5 58.5 65.1 24.8 5.7 33.1 23.0 9.1 14.5 15.1 15.3 0.1 45.5 8.8 0.4 13.3 4.6 32.0 24.5 38.3 19.0 6.1 44.3 2.1 0.8 0.3 1.2 0.7 0.2 1.2 1.5 0.9 1.3 0.6 1.0 1.4 1.2 1.0 1.9 0.2 0.9 0.1 0.6 4.5 4.8 7.3 5.2 4.5 6.1 4.6 4.0 3.3 3.4 5.9 3.9 7.3 9.6 10.3 21.5 14.3 30.2 23.8 7.4 17.1 28.5 21.6 16.5 23.4 27.1 11.5 16.5 31.3 2.8 7.1 6.8 5.9 11.9 5.5 15.1 13.6 8.8 10.8 18.3 29.5 10.4 2.4 12.0 15.3 20.6 6.3 17.3 8.9 9.2 3.4 8.4 38.9 21.4 6.1 6.7 17.9 9.0 24.5 6.8 17.8 26.2 14.6 11.1 4.1 32.2 27.3 18.1 7.9 19.2 15.5 44.4 5.2 15.6 12.2 24.3 6.6 26.9 20.3 5.3 6.6 24.4 31.7 1.2 10.5 5.3 28.4 17.4 PMPCA "Alpha-MPP, CLA1, INPP5E, KIAA0123, SCAR2" ENSG00000165688 "Peptidase, mitochondrial processing subunit alpha" Q10713 9 136410641-136423761 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Disease variant, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021648, HPA063735" Supported Enhanced Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 18: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Mitochondria "HPA021648: AB_1855491, HPA063735: AB_2685108" "unprognostic (9.80e-2)" "unprognostic (1.96e-2)" "unprognostic (4.03e-1)" "unprognostic (1.69e-2)" "unprognostic (4.01e-2)" "unprognostic (8.19e-2)" "unprognostic (6.09e-2)" "unprognostic (1.19e-2)" "unprognostic (1.97e-1)" "unprognostic (3.32e-2)" "prognostic favorable (8.00e-5)" "unprognostic (9.47e-3)" "prognostic favorable (2.14e-6)" "unprognostic (4.27e-3)" "unprognostic (1.57e-2)" "unprognostic (2.40e-1)" "unprognostic (3.54e-2)" 29.2 58.1 27.0 20.6 27.6 31.4 27.1 27.0 34.6 29.2 36.8 32.2 24.8 26.8 10.4 34.5 27.5 17.9 73.2 28.0 27.3 37.3 110.8 25.4 27.1 27.1 27.6 29.3 28.8 26.9 38.8 20.8 27.9 31.8 15.3 8.8 28.4 16.1 69.2 37.6 30.6 15.3 25.6 38.2 35.3 37.8 27.9 21.4 29.4 50.0 17.0 28.0 27.8 26.7 48.7 87.7 41.8 84.5 30.8 45.0 63.2 49.3 39.6 67.2 48.9 101.1 56.5 67.4 50.5 50.3 36.2 110.2 77.9 72.0 30.0 97.2 92.8 54.6 113.2 123.6 53.9 71.7 44.9 66.3 48.9 52.6 27.0 38.2 58.0 61.2 140.2 43.4 42.6 132.1 68.1 90.1 85.4 86.2 82.2 83.0 59.1 149.9 46.3 33.9 85.4 56.1 66.6 92.9 58.6 28.6 127.6 95.5 48.2 47.8 50.7 39.8 63.8 26.2 37.4 73.5 62.9 61.3 43.9 37.4 50.5 36.5 53.2 51.9 51.4 52.5 49.0 57.2 61.7 48.8 57.9 50.2 11.9 67.2 51.5 31.4 52.7 62.2 27.0 27.6 27.0 34.6 28.0 27.3 27.1 27.6 27.9 25.6 27.9 26.7 17.3 16.0 26.7 14.7 24.2 27.5 40.2 65.0 27.9 24.7 19.3 15.2 35.9 15.7 32.8 22.0 22.9 103.1 22.5 28.0 49.0 32.9 24.6 25.6 23.5 21.7 20.8 23.5 13.8 30.7 50.4 23.7 21.9 26.2 24.7 44.2 19.6 57.2 37.8 18.5 11.4 24.2 44.7 19.2 14.6 15.8 19.0 17.4 16.0 6.5 21.0 22.9 14.4 8.5 8.0 31.6 20.9 22.6 26.6 22.6 25.6 46.9 22.6 27.4 39.5 22.4 27.9 37.7 42.4 23.2 26.9 103.8 21.7 77.0 38.6 28.5 PMPCB "MPPB, MPPP52" ENSG00000105819 "Peptidase, mitochondrial processing subunit beta" O75439 7 103297435-103329511 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040674, HPA074168" Approved Enhanced Mitochondria No No 19000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Mitochondria "HPA040674: AB_10961998, HPA074168: AB_2686671" "prognostic favorable (2.79e-4)" "unprognostic (3.11e-1)" "unprognostic (7.18e-3)" "unprognostic (3.03e-1)" "unprognostic (3.65e-2)" "unprognostic (1.72e-1)" "unprognostic (1.06e-1)" "unprognostic (7.67e-2)" "unprognostic (7.74e-2)" "unprognostic (1.21e-1)" "unprognostic (1.38e-1)" "unprognostic (1.42e-3)" "prognostic favorable (2.95e-8)" "unprognostic (2.59e-2)" "unprognostic (9.79e-2)" "unprognostic (2.40e-1)" "unprognostic (4.39e-2)" 30.8 42.0 16.9 22.3 18.2 53.5 32.5 18.9 22.1 33.3 24.7 33.4 38.0 29.9 26.2 27.7 29.3 25.1 44.9 18.8 18.1 47.4 46.1 22.6 36.4 16.5 16.6 35.4 41.1 39.7 22.4 25.8 17.6 31.5 33.2 25.4 30.6 28.1 34.8 33.2 32.4 26.3 17.2 28.2 35.8 26.7 17.4 30.2 33.4 38.2 33.9 29.3 28.4 19.9 30.2 42.8 49.9 69.4 28.5 57.1 38.0 26.7 45.6 54.3 62.8 47.7 33.7 76.9 41.7 47.9 58.0 37.5 59.7 43.2 49.2 26.4 69.4 26.4 74.0 61.6 35.0 35.0 30.6 53.4 40.5 41.8 39.6 51.3 28.8 55.9 52.5 77.9 48.5 71.1 59.2 82.0 59.2 60.4 52.4 42.7 34.3 79.4 50.3 54.2 62.2 76.5 37.3 108.6 55.8 49.5 45.3 49.1 24.9 48.3 57.9 85.1 52.3 57.4 79.9 61.8 35.7 59.3 38.2 16.7 19.3 13.2 18.3 21.4 20.1 25.9 21.1 18.5 24.7 19.3 26.1 21.7 5.7 17.9 19.7 12.6 30.2 22.3 16.9 18.2 18.9 22.1 18.8 18.1 16.5 16.6 17.6 17.2 17.4 19.9 32.0 32.1 36.9 27.1 54.5 36.7 68.2 123.2 51.8 31.6 41.3 37.3 70.4 41.5 70.7 27.6 22.9 125.6 55.9 35.8 72.4 75.6 106.3 38.4 37.0 37.1 27.1 65.8 36.8 73.2 61.3 42.5 35.7 35.0 60.2 49.9 31.1 53.7 54.6 23.5 33.9 48.1 75.3 49.4 30.7 24.0 51.9 42.4 26.6 18.7 92.5 35.8 58.7 35.7 44.4 59.7 45.4 49.7 56.1 35.2 60.4 127.5 58.2 37.9 65.7 48.6 73.5 125.4 56.4 47.1 37.5 124.9 55.9 63.3 59.1 62.2 PSMD14 "pad1, POH1, Rpn11" ENSG00000115233 "Proteasome 26S subunit, non-ATPase 14" O00487 2 161308425-161411717 "Enzymes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002114, HPA003828" Approved Supported Nucleoplasm NA NA 26000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA002114: AB_1855850, HPA003828: AB_2667057" "unprognostic (3.50e-3)" "unprognostic (1.48e-1)" "unprognostic (9.61e-2)" "unprognostic (6.63e-2)" "unprognostic (2.57e-1)" "unprognostic (7.61e-3)" "prognostic unfavorable (2.66e-8)" "unprognostic (3.11e-2)" "unprognostic (4.04e-2)" "unprognostic (3.90e-3)" "unprognostic (9.84e-3)" "unprognostic (3.02e-1)" "prognostic unfavorable (3.10e-6)" "unprognostic (2.86e-2)" "unprognostic (4.70e-2)" "unprognostic (3.54e-1)" "unprognostic (1.66e-1)" 35.2 38.3 38.6 39.7 40.0 38.8 36.4 42.5 47.5 26.2 36.7 35.2 29.1 24.7 30.1 40.7 27.3 23.7 44.6 40.7 43.3 44.4 48.4 26.9 37.8 42.1 41.7 14.5 25.6 51.1 21.4 42.0 43.7 31.0 41.0 37.9 20.8 29.9 98.0 33.2 26.4 39.6 43.8 22.9 27.2 38.7 41.1 49.7 34.7 76.0 52.0 42.5 19.6 46.6 170.3 145.8 158.8 140.8 113.9 97.0 194.2 173.6 168.2 246.1 198.6 216.2 140.2 200.2 258.0 128.7 144.3 126.5 176.8 185.6 244.6 210.3 133.1 200.8 110.8 245.9 139.7 196.7 113.8 74.4 138.8 277.4 256.8 94.0 185.5 117.1 222.1 139.6 207.7 164.1 145.0 148.0 220.5 124.3 218.2 123.6 154.4 196.0 218.6 145.0 138.4 101.3 117.8 131.7 167.5 131.4 90.2 124.3 147.2 162.7 152.4 111.6 193.8 82.5 242.7 186.7 174.1 129.6 182.2 47.4 48.2 25.2 65.3 69.6 68.7 64.2 69.4 71.0 75.4 57.4 55.4 66.5 4.9 70.2 56.2 74.5 83.7 73.3 38.6 40.0 42.5 47.5 40.7 43.3 42.1 41.7 43.7 43.8 41.1 46.6 40.1 51.3 38.2 35.3 49.4 49.5 48.1 146.8 25.0 43.7 40.2 36.2 89.8 52.9 80.3 23.9 18.8 159.5 60.4 47.7 90.1 124.3 82.5 52.4 51.8 49.9 52.5 56.2 64.0 118.3 154.6 48.1 29.6 58.4 51.2 59.0 31.8 125.3 104.7 47.1 56.1 53.5 118.0 41.1 40.0 36.0 27.7 46.1 48.0 25.3 61.1 87.7 44.3 50.3 64.6 155.0 48.0 34.3 60.2 57.0 36.5 106.1 55.4 60.6 32.9 36.6 64.5 137.0 77.7 34.3 56.0 220.3 47.8 63.6 64.5 50.8 PSMD7 "MOV34, P40, Rpn8, S12" ENSG00000103035 "Proteasome 26S subunit, non-ATPase 7" P51665 16 74296814-74306288 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 596.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB019379, HPA049824, HPA056069" Enhanced Enhanced Nucleoplasm NA NA 190000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "CAB019379: , HPA049824: AB_2680899, HPA056069: AB_2683025" "unprognostic (4.75e-3)" "unprognostic (1.30e-1)" "unprognostic (2.84e-2)" "unprognostic (6.95e-2)" "unprognostic (7.62e-2)" "prognostic unfavorable (6.64e-5)" "prognostic unfavorable (7.71e-6)" "unprognostic (1.97e-2)" "unprognostic (6.51e-2)" "unprognostic (1.91e-2)" "unprognostic (9.34e-3)" "unprognostic (1.34e-2)" "unprognostic (2.52e-2)" "unprognostic (5.06e-3)" "unprognostic (7.04e-2)" "unprognostic (2.12e-1)" "unprognostic (1.86e-2)" 68.9 78.8 51.6 52.1 52.9 126.7 57.5 54.5 69.3 50.1 50.9 75.8 47.3 59.5 59.3 85.8 44.0 41.2 124.8 53.0 54.2 57.3 75.1 52.6 62.3 54.3 54.1 37.8 49.0 49.0 41.7 70.2 55.6 68.3 65.4 47.3 59.7 59.2 265.8 85.5 55.6 62.4 54.3 56.5 58.0 42.0 55.0 71.9 42.0 159.5 71.2 73.1 62.2 56.7 140.1 226.2 170.6 89.0 120.1 122.1 209.8 191.6 166.2 236.2 212.7 301.9 189.8 190.1 207.7 156.7 103.2 176.3 135.0 175.1 215.4 113.3 146.3 147.2 169.1 235.9 156.0 241.3 241.3 112.4 176.3 213.4 213.0 106.0 207.0 119.2 222.2 82.1 153.5 345.4 147.0 232.1 184.9 145.0 113.8 198.8 106.9 251.6 125.1 207.3 106.9 119.3 185.7 70.4 114.9 130.5 148.7 166.6 187.5 137.5 116.0 152.5 146.5 174.6 241.4 560.2 186.6 174.1 145.2 152.4 163.6 193.4 133.2 176.2 130.5 149.7 131.8 141.2 201.9 110.5 126.6 131.2 98.7 139.5 187.4 172.2 168.2 187.8 51.6 52.9 54.5 69.3 53.0 54.2 54.3 54.1 55.6 54.3 55.0 56.7 74.4 67.3 59.4 16.6 84.2 104.4 183.5 167.8 64.3 59.6 47.0 47.5 53.3 57.2 114.9 46.0 8.4 337.1 69.5 120.4 80.3 158.5 153.8 76.3 80.6 96.2 85.5 121.0 22.7 190.9 229.8 87.7 67.8 80.3 103.9 76.7 66.0 147.6 188.5 57.2 21.3 100.1 122.1 75.1 91.2 25.3 56.5 95.1 99.6 9.4 119.5 86.0 81.4 15.6 25.7 164.0 104.1 65.5 121.4 259.6 93.9 109.4 88.1 59.9 92.1 68.4 186.1 184.2 88.7 103.6 129.3 596.1 86.2 114.0 110.3 197.8 RNPEP APB ENSG00000176393 "Arginyl aminopeptidase" Q9H4A4 1 201982372-202006147 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 201.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 4 "dendritic cells: 19.8;granulocytes: 22.9;monocytes: 29.9" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036074, HPA036075, HPA061487" Approved Approved "Golgi apparatus" "Secreted - unknown location" NA NA 7800000 "Cluster 52: Eosinophils - Transcription" "Cluster 37: Intestine - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 45: Enterocytes - Digestion" "Golgi apparatus" "HPA036074: AB_2674926, HPA036075: AB_10672999, HPA061487: AB_2684537" "unprognostic (8.57e-2)" "unprognostic (3.43e-2)" "unprognostic (2.81e-1)" "unprognostic (5.45e-2)" "unprognostic (2.68e-1)" "unprognostic (1.74e-2)" "unprognostic (1.95e-2)" "unprognostic (2.87e-2)" "unprognostic (1.93e-3)" "unprognostic (1.80e-1)" "unprognostic (1.07e-1)" "unprognostic (1.28e-1)" "unprognostic (3.50e-3)" "unprognostic (1.91e-1)" "unprognostic (6.00e-2)" "unprognostic (1.97e-2)" "unprognostic (1.68e-1)" 25.2 31.1 8.0 22.8 8.3 25.2 25.8 8.1 8.5 26.7 16.1 53.6 68.5 25.6 39.0 53.8 40.6 22.3 14.7 8.5 8.7 25.9 32.4 30.5 22.1 9.9 9.1 23.4 34.1 25.4 13.3 27.5 9.1 25.9 57.0 4.2 38.3 27.6 18.8 37.0 58.1 28.1 9.1 33.4 28.5 17.9 10.6 21.7 33.2 12.7 26.5 23.3 28.8 11.8 66.2 71.0 40.8 62.7 65.1 61.3 102.1 49.5 95.6 60.9 67.6 51.8 83.1 14.3 61.8 87.8 38.0 117.4 52.5 97.2 42.4 39.1 67.6 35.5 32.5 48.7 55.1 92.3 121.3 55.9 97.9 54.1 62.0 74.7 110.6 34.8 82.5 21.6 62.1 61.0 12.8 40.2 58.4 105.4 34.4 48.3 57.5 101.6 128.7 61.2 46.9 39.9 122.2 155.9 52.1 78.9 116.6 52.4 79.9 28.9 38.0 28.7 61.3 45.3 39.6 12.9 27.8 77.3 58.1 22.9 14.9 22.1 3.0 25.9 4.1 2.5 3.2 3.4 19.8 4.6 2.8 3.2 11.0 2.9 29.9 7.2 5.4 4.0 8.0 8.3 8.1 8.5 8.5 8.7 9.9 9.1 9.1 9.1 10.6 11.8 26.7 9.6 21.5 8.5 19.7 28.8 40.5 31.2 40.5 15.5 32.8 33.1 12.2 38.6 26.7 25.8 10.4 116.6 21.4 136.6 19.6 71.1 5.4 35.9 17.7 26.1 44.9 19.0 12.7 51.2 91.1 26.1 45.3 21.5 15.2 23.2 27.1 51.4 103.7 11.8 11.1 71.9 14.2 81.0 39.4 4.9 25.4 72.9 24.9 15.0 86.7 12.6 17.5 5.5 8.1 47.8 83.4 23.0 23.6 25.0 201.7 65.8 39.1 8.0 26.3 11.4 28.2 22.7 9.5 53.6 21.6 87.6 17.7 33.2 86.6 34.8 RNPEPL1 ENSG00000142327 "Arginyl aminopeptidase like 1" Q9HAU8 2 240565804-240581372 "Enzymes, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 138.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036772, HPA036773" Uncertain Supported "Nucleoplasm,Nuclear bodies" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 25: RPMI-8226 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "Nuclear bodies" "HPA036772: AB_10670848, HPA036773: " "unprognostic (3.92e-2)" "unprognostic (7.28e-2)" "unprognostic (1.20e-2)" "unprognostic (2.39e-1)" "unprognostic (5.24e-3)" "prognostic favorable (7.43e-4)" "prognostic unfavorable (5.06e-4)" "unprognostic (3.72e-3)" "unprognostic (9.10e-2)" "unprognostic (1.66e-3)" "unprognostic (3.10e-1)" "unprognostic (1.71e-1)" "unprognostic (1.98e-2)" "unprognostic (5.33e-2)" "unprognostic (1.57e-1)" "unprognostic (5.31e-2)" "unprognostic (9.86e-2)" 40.3 31.4 29.1 14.1 29.6 21.7 32.0 29.0 38.7 15.6 27.0 39.6 20.2 16.8 5.6 52.4 17.0 12.1 79.4 27.9 27.8 42.7 50.6 35.9 23.8 31.5 30.0 12.0 64.2 10.9 9.1 10.6 30.3 34.7 9.5 0.8 28.9 13.1 63.7 35.3 39.8 9.4 31.0 56.4 48.4 9.9 31.4 15.9 19.2 17.1 12.1 34.1 23.2 31.1 13.7 22.4 4.9 13.2 17.6 18.1 16.6 8.6 21.1 9.5 11.6 6.3 39.3 3.9 4.3 21.8 13.3 14.6 5.5 16.1 0.9 23.9 7.7 9.0 7.3 37.2 44.1 5.9 15.5 21.6 25.5 4.9 9.6 15.1 32.8 15.2 6.8 25.7 6.5 19.3 7.5 22.4 6.5 26.5 9.0 15.5 7.4 33.3 39.3 18.5 4.6 9.8 5.8 19.7 39.9 5.6 13.9 26.8 22.7 10.2 10.4 14.4 10.0 24.1 3.9 4.8 20.9 16.6 15.7 9.2 11.2 30.5 14.8 9.9 12.7 8.2 11.3 13.4 8.2 8.7 6.4 9.5 20.0 10.7 10.1 9.5 14.7 7.9 29.1 29.6 29.0 38.7 27.9 27.8 31.5 30.0 30.3 31.0 31.4 31.1 27.9 22.4 25.7 10.4 27.8 7.8 15.0 8.4 2.8 6.4 18.8 9.1 35.6 24.3 12.9 12.9 0.0 7.1 80.4 138.9 17.6 24.6 3.1 12.1 11.0 22.7 26.4 22.3 9.5 49.6 6.8 12.3 104.5 27.4 34.2 31.8 30.0 42.2 43.8 3.3 8.6 58.7 8.2 74.3 21.0 5.9 8.7 47.1 23.2 9.4 52.0 15.9 79.3 5.5 10.3 65.0 70.0 13.5 20.5 20.2 77.1 35.6 7.2 6.9 13.1 14.8 16.4 1.3 8.2 13.0 9.2 5.1 47.9 17.4 60.5 23.0 SPG7 "CAR, CMAR, SPG5C" ENSG00000197912 "SPG7 matrix AAA peptidase subunit, paraplegin" Q9UQ90 16 89490719-89557766 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration, Osteogenesis imperfecta" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 11: Basophils - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 52: Non-specific - Transcription" "unprognostic (1.42e-1)" "unprognostic (1.72e-1)" "unprognostic (4.12e-2)" "prognostic favorable (2.22e-4)" "unprognostic (4.10e-1)" "unprognostic (1.11e-2)" "unprognostic (1.14e-1)" "unprognostic (1.50e-1)" "unprognostic (1.54e-1)" "unprognostic (2.33e-1)" "prognostic favorable (4.91e-4)" "unprognostic (3.56e-2)" "unprognostic (7.01e-2)" "unprognostic (1.44e-2)" "unprognostic (2.58e-1)" "unprognostic (1.71e-1)" "prognostic favorable (4.25e-4)" 29.8 44.8 19.3 7.0 18.8 8.2 27.9 21.3 28.6 31.5 18.5 33.3 9.9 31.8 4.0 28.2 26.4 6.8 52.3 19.4 18.3 32.4 47.0 24.9 8.9 19.7 18.6 39.0 31.9 13.8 38.7 5.9 20.3 31.2 8.1 9.9 29.0 9.7 56.7 31.3 35.5 9.0 16.9 34.1 31.1 31.9 18.7 10.5 53.1 31.0 8.0 30.1 26.9 20.0 11.5 28.3 17.3 26.6 33.2 24.2 10.9 27.3 24.6 21.0 10.4 23.0 22.3 16.5 32.5 20.1 16.2 30.5 21.5 24.4 14.7 11.7 25.3 11.4 12.0 43.4 16.2 5.5 10.3 15.2 20.1 12.8 14.1 27.9 25.6 22.0 23.1 5.5 21.7 21.0 14.4 22.5 21.9 23.8 21.4 31.8 26.2 10.8 15.9 17.3 16.4 10.5 44.9 8.3 9.5 15.2 22.6 17.0 33.7 13.9 17.2 12.0 12.2 13.7 19.8 12.8 17.7 19.8 17.7 4.5 2.5 3.9 2.7 2.4 2.6 1.6 1.7 1.3 2.8 3.4 3.1 2.0 2.9 3.7 1.7 2.3 1.8 1.0 19.3 18.8 21.3 28.6 19.4 18.3 19.7 18.6 20.3 16.9 18.7 20.0 53.9 48.1 49.4 39.2 45.6 15.9 27.9 30.1 44.9 57.8 31.2 37.2 45.8 22.8 41.5 35.0 95.9 39.9 47.6 42.3 19.6 40.0 66.0 50.5 41.7 49.9 37.2 27.3 58.5 25.8 28.8 35.9 67.2 54.1 21.5 95.3 51.0 38.1 32.2 40.4 53.1 43.8 30.5 34.8 21.8 22.1 42.9 35.2 21.4 35.6 42.6 30.5 51.5 87.0 46.2 39.5 39.5 33.4 43.5 29.5 68.2 23.8 37.7 73.7 6.6 36.9 36.2 57.5 36.5 36.7 18.0 25.9 45.5 68.3 51.0 28.7 STAMBP AMSH ENSG00000124356 "STAM binding protein" O95630 2 73828916-73873659 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 12 "LHCN-M2: 1108.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035800, HPA035801" Uncertain Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA 18000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 80: Striated muscle - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "Plasma membrane, Cytosol" "HPA035800: AB_10670591, HPA035801: AB_2732470" "unprognostic (1.86e-2)" "unprognostic (1.14e-1)" "unprognostic (2.16e-1)" "prognostic unfavorable (4.70e-5)" "unprognostic (6.13e-2)" "unprognostic (2.08e-3)" "unprognostic (3.73e-2)" "unprognostic (1.71e-1)" "unprognostic (6.58e-2)" "unprognostic (2.96e-2)" "prognostic unfavorable (5.79e-4)" "unprognostic (1.01e-1)" "unprognostic (2.29e-1)" "unprognostic (7.72e-2)" "unprognostic (2.63e-1)" "unprognostic (1.43e-1)" "unprognostic (2.89e-1)" 15.6 11.6 21.7 14.6 30.6 13.3 20.2 29.7 23.8 19.3 19.3 21.5 20.7 20.6 15.5 25.4 18.3 16.9 22.3 20.6 24.5 21.9 19.0 15.7 19.3 31.3 28.0 17.7 12.2 24.3 9.3 17.3 30.4 22.1 23.2 14.6 21.5 15.6 37.4 16.7 20.4 21.3 27.9 14.9 18.2 15.8 27.1 23.2 22.6 42.8 21.6 16.8 16.0 38.6 39.0 44.0 34.0 31.6 31.1 37.2 39.1 23.3 31.7 42.1 40.3 73.7 35.9 32.2 35.8 19.8 55.7 30.0 36.6 81.7 47.6 56.6 41.3 43.3 29.1 58.1 43.4 35.8 50.0 30.1 57.6 49.6 70.7 53.5 25.1 43.7 47.9 47.8 1108.9 46.8 55.9 32.4 54.9 55.1 22.7 38.6 89.4 46.1 45.2 43.0 62.0 45.8 28.4 34.6 49.1 36.4 32.3 21.4 22.0 37.5 44.5 22.9 41.9 44.8 46.9 24.9 46.4 38.1 44.7 30.7 18.9 34.2 15.9 21.4 17.2 21.5 18.3 15.6 19.9 19.3 18.9 14.4 27.6 22.3 19.9 19.5 25.8 14.9 21.7 30.6 29.7 23.8 20.6 24.5 31.3 28.0 30.4 27.9 27.1 38.6 22.1 19.2 17.7 22.9 21.5 16.3 28.9 61.7 31.3 22.3 28.8 27.7 41.1 28.6 34.4 25.8 12.5 43.0 27.4 48.7 49.0 37.9 80.8 35.6 37.3 21.4 10.3 34.9 18.5 36.3 32.5 26.0 18.8 45.8 52.6 21.2 17.5 41.1 33.0 26.9 22.1 36.4 40.7 27.7 16.2 125.0 32.6 25.2 7.2 16.9 34.1 24.9 25.7 26.2 67.2 44.5 41.8 34.6 21.5 40.9 57.2 68.8 24.5 21.0 39.5 28.2 27.2 33.1 44.2 44.5 21.6 44.5 21.4 27.5 34.3 27.1 STAMBPL1 "ALMalpha, AMSH-FP, AMSH-LP, bA399O19.2, FLJ31524, KIAA1373" ENSG00000138134 "STAM binding protein like 1" Q96FJ0 10 88879734-88975153 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 23.8" "Cell type enhanced" "Detected in many" "Early spermatids: 54.3;Excitatory neurons: 60.5;Microglial cells: 32.8;Spermatocytes: 40.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040202 Uncertain Approved "Plasma membrane" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 14: B-cells - Humoral immune response" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" "HPA040202: AB_10805708" "unprognostic (2.73e-1)" "unprognostic (1.95e-1)" "unprognostic (7.56e-2)" "unprognostic (4.25e-2)" "unprognostic (6.46e-2)" "unprognostic (6.27e-2)" "unprognostic (1.68e-2)" "unprognostic (1.05e-2)" "unprognostic (4.67e-2)" "unprognostic (8.20e-2)" "unprognostic (2.78e-1)" "unprognostic (6.57e-2)" "prognostic unfavorable (1.08e-5)" "unprognostic (4.41e-2)" "unprognostic (4.06e-2)" "unprognostic (1.50e-1)" "unprognostic (4.40e-3)" 3.9 23.8 5.5 10.4 6.5 5.3 2.5 2.6 9.0 2.7 0.0 8.7 6.4 4.2 0.9 4.4 2.2 4.1 8.0 6.2 1.4 1.8 1.8 3.6 16.2 1.1 0.5 12.7 2.3 3.4 5.5 1.2 2.6 1.7 9.7 4.4 1.4 1.1 0.7 3.7 7.3 3.0 1.9 7.2 5.1 18.0 0.5 7.1 1.2 1.5 12.2 6.4 2.5 5.6 14.8 16.5 1.0 0.6 14.4 27.7 0.0 31.5 28.9 19.0 16.3 0.3 25.6 18.6 2.3 15.6 12.3 6.4 4.1 4.5 17.9 16.3 10.8 4.6 10.4 0.9 10.3 20.2 5.7 10.6 1.4 31.6 9.6 18.4 0.6 20.9 0.0 7.3 50.0 3.0 34.2 21.5 6.6 13.3 14.1 3.4 13.0 3.8 6.5 4.7 9.6 11.9 3.7 1.1 37.5 3.6 2.3 4.1 4.9 17.0 12.4 20.7 19.9 17.7 19.7 17.2 18.2 19.4 16.9 9.5 1.0 8.1 10.7 1.1 14.1 17.7 15.5 13.7 1.7 14.9 16.6 10.0 1.4 23.6 0.5 27.9 28.3 8.0 5.5 6.5 2.6 9.0 6.2 1.4 1.1 0.5 2.6 1.9 0.5 5.6 2.3 0.0 4.5 10.7 16.7 9.6 5.3 1.4 1.2 3.6 2.3 1.4 8.6 0.0 0.2 5.5 0.0 0.1 18.8 7.6 0.0 1.3 54.3 1.9 6.5 1.8 9.1 3.4 60.5 1.8 0.1 7.7 3.1 1.4 5.1 7.4 1.8 2.4 3.7 6.7 26.2 9.3 4.1 1.3 9.6 20.7 7.2 3.1 0.0 32.8 1.0 9.3 12.3 26.2 1.9 1.9 2.8 1.5 14.2 1.9 7.9 0.8 5.0 0.4 0.0 20.4 6.4 40.2 2.5 5.9 11.4 0.1 17.6 14.9 14.2 2.9 SUPT16H "CDC68, FACT, FACTP140, FLJ10857, FLJ14010, SPT16/CDC68" ENSG00000092201 "SPT16 homolog, facilitates chromatin remodeling subunit" Q9Y5B9 14 21351476-21384019 "Enzymes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication, Host-virus interaction, Transcription, Transcription regulation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022551, HPA049787" Enhanced Supported "Nucleoplasm,Nucleoli fibrillar center" NA NA 27000 "Cluster 27: Non-specific - Gene expression" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "Nucleoli fibrillar center" "CAB022551: , HPA049787: AB_2680881" "unprognostic (1.65e-1)" "unprognostic (2.22e-1)" "unprognostic (3.52e-2)" "unprognostic (7.12e-2)" "unprognostic (7.32e-2)" "unprognostic (1.22e-2)" "unprognostic (1.38e-3)" "unprognostic (1.86e-1)" "unprognostic (7.65e-2)" "unprognostic (4.91e-2)" "unprognostic (1.09e-1)" "unprognostic (1.26e-1)" "unprognostic (6.48e-3)" "unprognostic (1.02e-1)" "unprognostic (7.58e-3)" "unprognostic (9.05e-2)" "unprognostic (5.87e-3)" 29.3 24.8 9.7 36.6 11.1 42.3 35.9 18.8 13.9 34.2 8.2 30.6 23.1 41.1 19.5 29.0 32.0 24.1 24.1 9.7 15.6 28.6 22.4 26.3 51.2 11.3 12.0 43.6 22.6 46.2 13.5 32.1 12.0 29.9 35.1 44.4 20.9 32.6 21.8 28.9 25.9 36.6 10.7 32.9 26.3 43.3 12.1 56.8 33.3 24.6 51.8 35.6 20.1 12.3 147.8 136.9 185.5 136.6 85.5 81.7 131.4 130.3 103.2 155.5 145.4 133.9 129.5 311.3 48.5 96.5 99.7 153.9 237.2 118.9 234.0 99.8 100.9 188.7 121.9 195.1 87.0 270.1 134.7 73.4 72.6 131.0 146.3 75.4 107.7 174.2 158.1 129.4 131.3 99.9 253.6 85.8 207.1 136.2 134.1 270.3 210.6 168.0 63.9 160.8 183.8 157.2 209.8 125.3 81.1 118.7 69.2 127.9 91.1 135.0 113.4 85.0 143.3 128.8 230.2 306.7 49.9 158.0 104.9 35.6 18.3 28.2 29.6 23.9 34.7 31.2 27.9 33.2 23.7 27.4 31.3 32.2 15.0 34.0 31.1 22.2 28.4 25.2 9.7 11.1 18.8 13.9 9.7 15.6 11.3 12.0 12.0 10.7 12.1 12.3 41.5 64.1 55.9 24.2 51.6 35.6 44.3 51.5 45.5 48.9 46.3 49.7 64.2 22.8 50.3 53.3 47.9 65.1 73.6 28.4 25.4 71.0 142.5 52.0 124.3 46.9 23.4 74.6 27.4 61.1 63.9 61.1 29.6 61.7 84.2 73.4 29.3 32.0 41.9 55.5 30.1 31.2 40.7 34.9 25.2 96.1 59.7 40.7 17.8 20.6 90.9 53.3 64.9 16.1 25.2 68.9 15.2 59.8 39.5 46.1 16.5 30.4 40.2 41.1 19.7 78.5 69.5 128.9 152.8 45.1 41.5 45.6 56.3 61.6 43.0 35.7 TFR2 "HFE3, TFRC2" ENSG00000106327 "Transferrin receptor 2" Q9UP52 7 100620416-100642779 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted membrane proteins, Transporters" Receptor "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 15 "liver: 346.1" "Group enriched" "Detected in some" 13 "Erythroid cells: 152.8;Hepatocytes: 455.7" "Cancer enriched" "Detected in many" 70 "liver cancer: 136.2" "Not detected" "Not detected" "Group enriched" "Detected in some" 22 "basophil: 2.5;eosinophil: 1.9" "Lineage enriched" "Detected in single" 25 "granulocytes: 2.5" "Group enriched" "Detected in some" 11 "HEL: 69.7;HMC-1: 92.7;K-562: 65.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB016255, HPA017171, HPA073125" Enhanced Approved "Golgi apparatus" NA NA 410000 "Cluster 46: Basophils - DNA binding" "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 1: K-562 - Erythropoiesis" "Cluster 15: Hepatocytes - Hemostasis" "Golgi apparatus" "CAB016255: AB_628395, HPA017171: , HPA073125: " "unprognostic (4.18e-2)" "unprognostic (1.97e-2)" "unprognostic (2.74e-1)" "unprognostic (1.04e-1)" "unprognostic (1.26e-2)" "unprognostic (4.13e-2)" "prognostic favorable (2.48e-4)" "unprognostic (2.29e-2)" "unprognostic (4.49e-2)" "unprognostic (9.26e-2)" "unprognostic (1.93e-1)" "unprognostic (2.90e-1)" "unprognostic (1.18e-9)" "unprognostic (6.51e-2)" "unprognostic (1.68e-1)" "unprognostic (3.28e-1)" "unprognostic (8.18e-2)" 0.0 0.1 0.0 0.0 0.0 22.5 0.0 0.6 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.1 0.0 0.0 346.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.2 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 6.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 69.7 0.0 7.2 0.0 1.6 92.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 65.8 0.0 0.0 0.0 0.0 0.1 0.1 0.4 0.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 2.5 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.3 2.1 0.3 0.9 0.4 0.0 8.5 0.3 0.6 1.2 10.0 0.8 0.0 8.4 0.1 1.7 0.1 0.0 0.4 5.8 0.1 0.6 1.2 0.0 152.8 5.4 0.2 1.1 0.5 1.5 0.2 0.0 0.2 7.1 455.7 0.3 21.9 5.4 0.3 0.0 8.6 1.7 8.4 0.0 0.4 0.0 1.0 0.2 0.4 6.2 1.5 0.7 0.1 0.1 0.0 0.4 0.6 0.1 0.1 0.3 1.9 0.0 0.4 0.7 0.7 2.9 0.2 0.6 0.1 2.6 0.1 0.6 0.5 TFRC "CD71, p90, TFR1" ENSG00000072274 "Transferrin receptor" P02786 3 196027183-196082096 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters" "Endocytosis, Host-virus interaction" "Host cell receptor for virus entry, Receptor, Transducer" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 254.5" "Cell type enhanced" "Detected in many" "Erythroid cells: 556.4;Syncytiotrophoblasts: 502.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 860.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000153, HPA028598" Enhanced Supported Endosomes,Lysosomes "Secreted to blood" NA NA 1310000000 38000000 "Cluster 27: Non-specific - Gene expression" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 36: HEL - Hemostasis" "Cluster 6: Erythroid cells - Oxygen transport" "Endosomes, Lysosomes" "CAB000153: AB_2533029, HPA028598: AB_10601599" "unprognostic (2.95e-2)" "prognostic unfavorable (3.67e-4)" "unprognostic (2.55e-1)" "unprognostic (1.48e-2)" "unprognostic (6.75e-2)" "unprognostic (7.88e-3)" "prognostic unfavorable (1.15e-4)" "unprognostic (6.92e-2)" "unprognostic (3.30e-3)" "unprognostic (4.35e-2)" "unprognostic (1.34e-2)" "unprognostic (1.14e-2)" "unprognostic (3.63e-3)" "unprognostic (3.65e-2)" "unprognostic (1.19e-2)" "prognostic unfavorable (2.96e-4)" "unprognostic (2.62e-2)" 44.6 28.7 21.6 63.4 18.3 254.5 20.2 18.5 32.3 31.3 15.7 77.2 35.9 23.8 11.1 36.0 25.9 24.9 31.0 21.9 19.0 26.4 27.8 78.0 23.0 24.2 19.9 93.9 15.9 44.8 13.1 103.2 26.3 13.2 55.6 47.3 15.7 13.4 76.2 21.8 32.1 31.5 20.8 15.5 21.4 21.6 25.3 22.0 20.1 68.7 28.1 68.5 17.4 20.7 175.3 155.0 69.8 142.1 151.7 87.3 438.7 242.5 183.7 168.1 276.3 384.6 156.6 178.5 446.3 91.0 363.5 261.8 243.3 81.1 204.2 860.4 82.4 677.4 120.2 179.2 119.4 561.8 130.4 99.1 78.6 144.5 129.0 47.8 56.9 95.6 287.3 164.1 132.8 161.7 185.8 116.8 214.9 228.6 314.0 97.3 103.9 214.1 148.3 435.3 159.3 65.9 234.4 613.9 55.2 115.9 595.0 115.8 72.5 198.4 159.7 175.3 369.7 46.3 387.8 276.7 232.3 149.2 122.3 0.0 1.6 2.2 2.2 7.3 1.4 5.1 2.4 1.5 3.5 3.1 2.1 1.7 0.2 1.9 13.2 7.1 6.4 2.1 21.6 18.3 18.5 32.3 21.9 19.0 24.2 19.9 26.3 20.8 25.3 20.7 25.4 44.8 32.1 43.1 46.6 60.3 37.2 33.6 21.1 53.1 37.1 34.9 103.0 41.5 38.8 20.2 148.0 122.5 53.2 156.6 0.0 49.4 3.5 35.3 20.3 23.6 56.1 556.4 24.7 41.8 25.3 32.4 77.5 56.1 23.4 40.2 8.6 93.2 73.4 13.5 28.3 67.8 22.4 37.1 77.6 5.3 11.5 161.7 17.8 44.0 49.4 22.0 9.2 11.6 8.2 52.0 50.8 8.6 42.1 25.6 48.3 13.1 32.1 44.4 26.3 36.3 29.3 23.8 18.2 51.3 35.8 502.7 42.6 16.6 103.5 23.7 THOP1 ENSG00000172009 "Thimet oligopeptidase 1" P52888 19 2785503-2815807 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 136.6;Paneth cells: 160.6;Proximal enterocytes: 312.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025497, HPA035262" Uncertain Supported Cytosol NA NA 2000000 "Cluster 18: Basophils - Vesicular transport" "Cluster 43: Testis - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 45: Enterocytes - Digestion" Cytosol "CAB025497: , HPA035262: AB_2674541" "unprognostic (1.52e-2)" "unprognostic (1.73e-3)" "unprognostic (7.94e-2)" "prognostic favorable (2.35e-4)" "unprognostic (1.82e-1)" "unprognostic (2.16e-2)" "unprognostic (9.35e-2)" "unprognostic (1.19e-1)" "unprognostic (4.05e-2)" "unprognostic (1.43e-1)" "unprognostic (1.20e-3)" "unprognostic (3.00e-2)" "unprognostic (1.39e-1)" "prognostic favorable (5.90e-4)" "unprognostic (1.27e-1)" "unprognostic (2.64e-1)" "unprognostic (5.37e-2)" 13.4 19.6 31.8 11.8 31.6 19.6 15.3 29.8 48.4 15.3 25.4 21.3 22.6 18.7 6.3 31.0 17.6 3.3 38.0 33.2 28.7 22.7 73.0 13.7 11.6 33.7 31.7 18.8 17.5 6.0 32.0 7.8 30.7 37.6 7.0 9.3 15.7 5.2 40.6 20.0 21.5 6.1 26.9 23.0 16.1 70.2 28.6 13.8 17.9 11.0 8.3 18.7 15.9 30.4 91.4 66.3 25.1 54.6 12.8 12.5 89.9 55.4 20.4 53.8 43.4 78.4 28.3 81.3 26.4 21.7 37.7 72.4 37.8 45.6 22.5 0.3 79.7 28.9 75.9 94.4 13.7 56.3 43.1 13.9 16.0 44.8 20.0 15.5 31.0 54.0 68.2 38.7 23.1 70.5 63.1 105.0 74.7 27.2 90.2 51.7 33.8 77.5 22.8 51.9 68.5 54.6 48.5 42.9 27.6 13.1 41.8 53.8 35.5 41.2 35.5 88.6 95.4 67.1 60.7 55.7 46.0 93.3 50.1 9.3 2.5 1.2 3.7 2.9 3.0 3.8 2.7 5.2 3.6 5.3 3.4 3.0 1.0 3.0 6.0 7.0 7.6 2.5 31.8 31.6 29.8 48.4 33.2 28.7 33.7 31.7 30.7 26.9 28.6 30.4 5.1 3.2 10.6 15.0 12.0 6.8 10.3 15.6 11.4 20.3 12.6 10.8 9.0 5.7 9.7 11.0 35.5 27.6 8.7 136.6 9.8 18.7 17.6 11.1 8.3 7.4 40.8 13.7 12.1 15.1 55.9 11.1 9.2 10.1 5.7 23.1 7.1 85.9 23.0 6.7 10.5 59.9 6.1 9.8 6.0 23.4 11.5 9.1 3.6 3.7 8.3 13.5 4.1 4.0 7.1 21.3 160.6 6.0 17.2 16.6 312.2 10.8 9.7 32.4 13.1 10.6 15.0 55.6 19.2 13.4 5.8 33.8 8.0 15.9 48.2 8.4 TRHDE "PAP-II, PGPEP2, TRH-DE" ENSG00000072657 "Thyrotropin releasing hormone degrading enzyme" Q9UKU6 12 72087266-72670758 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 7.6;pancreas: 10.3" "Group enriched" "Detected in some" 4 "Excitatory neurons: 216.9;Inhibitory neurons: 292.7" "Cancer enhanced" "Detected in some" "renal cancer: 1.9" "Group enriched" "Detected in many" 5 "basal ganglia: 4.9;cerebellum: 4.4;cerebral cortex: 2.5;hippocampal formation: 7.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ: 30.3;BJ hTERT+: 29.1;EFO-21: 15.3;HBF TERT88: 10.3;hTERT-RPE1: 10.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA 7300000 "Cluster 22: Non-specific - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (3.56e-2)" "unprognostic (4.06e-3)" "unprognostic (6.01e-2)" "unprognostic (1.44e-6)" "unprognostic (1.77e-1)" "unprognostic (6.37e-2)" "unprognostic (7.79e-2)" "unprognostic (6.96e-2)" "unprognostic (3.99e-2)" "unprognostic (1.48e-1)" "unprognostic (5.14e-4)" "unprognostic (2.40e-1)" "prognostic favorable (1.53e-7)" "unprognostic (2.55e-2)" "unprognostic (2.48e-1)" "unprognostic (8.91e-3)" "unprognostic (2.94e-2)" 3.6 0.9 0.1 0.3 4.9 0.4 0.8 4.4 2.5 3.7 0.0 1.1 2.4 1.2 0.6 0.2 1.1 0.8 0.8 7.6 0.0 5.1 0.5 1.4 0.1 0.0 0.9 3.2 10.3 0.0 0.1 0.1 0.0 1.3 0.5 0.8 0.8 2.8 0.2 0.2 2.1 0.4 0.0 2.5 0.3 0.7 0.0 0.1 0.0 0.4 0.3 1.2 2.3 0.0 3.6 0.0 0.6 0.0 1.6 0.0 9.5 30.3 29.1 2.9 1.9 0.0 0.0 0.0 15.3 4.3 3.0 0.4 5.4 0.0 10.3 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 2.4 0.0 0.0 2.3 10.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 8.7 0.0 0.0 0.0 9.5 6.7 2.9 0.1 0.0 0.0 0.0 0.5 0.0 5.7 0.0 0.0 3.2 0.0 0.5 0.0 0.0 0.0 0.0 0.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 4.9 4.4 2.5 7.6 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.2 0.0 0.5 2.9 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.9 1.5 0.0 1.8 0.0 0.1 0.0 7.1 3.9 0.0 35.9 0.1 0.4 0.2 0.0 0.0 216.9 2.6 0.4 4.7 0.0 0.3 0.0 0.1 0.4 1.4 0.2 0.0 292.7 3.5 0.0 0.0 0.0 62.8 29.5 0.7 0.0 2.8 0.0 0.4 0.0 38.2 4.0 2.2 3.9 13.5 0.0 0.2 15.8 9.1 0.7 0.6 0.0 37.4 0.6 0.2 0.7 0.0 0.0 0.1 0.1 0.2 1.6 0.1 UQCRC1 "D3S3191, QCR1, UQCR1" ENSG00000010256 "Ubiquinol-cytochrome c reductase core protein 1" P31930 3 48599002-48610976 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Electron transport, Respiratory chain, Transport" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 766.7;tongue: 882.7" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 662.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002815, HPA003525, CAB033782" Enhanced Supported Mitochondria NA NA 250000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 39: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "CAB033782: AB_2213631, HPA002815: AB_1080486, HPA003525: AB_1080484" "unprognostic (1.29e-1)" "unprognostic (3.15e-3)" "unprognostic (6.91e-3)" "unprognostic (1.06e-1)" "unprognostic (1.66e-1)" "unprognostic (9.91e-2)" "unprognostic (8.53e-2)" "unprognostic (1.99e-1)" "unprognostic (3.11e-2)" "unprognostic (9.14e-2)" "unprognostic (3.37e-1)" "unprognostic (7.20e-2)" "prognostic favorable (2.35e-10)" "unprognostic (5.37e-2)" "unprognostic (2.35e-1)" "unprognostic (1.02e-1)" "unprognostic (6.72e-2)" 66.0 58.2 93.7 46.9 97.1 62.4 55.0 117.3 110.1 50.7 127.2 156.9 156.3 35.5 50.4 78.9 66.2 33.9 387.7 96.7 115.0 131.3 149.0 42.1 42.8 111.0 101.7 36.1 87.4 192.2 30.6 56.0 114.6 51.8 129.6 52.9 105.9 77.5 766.7 78.6 125.4 62.8 99.3 41.0 103.3 52.1 111.6 72.7 48.4 882.7 58.0 63.5 40.0 101.4 118.2 169.6 136.7 145.0 147.5 117.0 225.2 129.4 206.1 196.5 178.9 272.8 107.1 193.4 94.4 143.2 274.1 123.6 171.6 280.9 91.7 138.3 173.8 214.7 186.7 317.1 186.9 164.4 152.2 150.9 293.6 183.2 274.6 167.5 172.5 173.7 110.5 107.1 152.5 192.0 156.7 241.6 157.6 229.6 324.2 103.4 138.1 273.5 235.8 178.7 84.4 107.5 182.8 218.7 211.8 92.0 163.1 178.0 112.5 107.7 153.7 179.5 272.4 124.8 121.4 136.5 192.7 233.9 319.0 251.3 643.7 325.4 204.7 665.7 193.7 260.0 203.5 206.1 593.3 227.7 177.1 175.2 158.2 194.4 608.0 235.0 258.1 988.2 93.7 97.1 117.3 110.1 96.7 115.0 111.0 101.7 114.6 99.3 111.6 101.4 31.5 57.7 50.4 17.3 59.0 117.6 164.6 339.4 103.6 41.9 59.3 46.1 662.2 140.2 139.2 121.4 29.2 334.4 28.0 550.2 365.9 163.7 155.0 64.0 41.6 53.4 144.5 80.6 16.9 166.3 311.1 78.2 167.7 61.5 82.4 72.5 49.6 188.0 238.2 40.4 22.0 319.6 223.8 118.1 85.4 331.9 58.4 107.7 119.2 12.2 129.1 67.1 51.5 14.6 12.5 163.5 333.3 70.7 117.6 78.4 553.4 398.4 104.7 65.0 59.2 61.2 153.0 110.3 74.7 173.0 105.4 336.7 50.8 172.1 416.8 153.4 UQCRC2 "QCR2, UQCR2" ENSG00000140740 "Ubiquinol-cytochrome c reductase core protein 2" P22695 16 21953288-21983660 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Electron transport, Respiratory chain, Transport" "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 722.2;tongue: 933.2" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 556.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007998, HPA019146" Enhanced Enhanced Mitochondria NA NA 180000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 8: Non-specific - Mitochondria" "Cluster 3: HMC-1 - Innate immune response" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "HPA007998: AB_1858648, HPA019146: AB_1858649" "unprognostic (1.33e-1)" "unprognostic (1.32e-1)" "unprognostic (1.49e-3)" "unprognostic (3.35e-1)" "unprognostic (1.26e-2)" "unprognostic (6.91e-2)" "unprognostic (2.71e-2)" "unprognostic (1.32e-1)" "unprognostic (1.72e-1)" "unprognostic (8.87e-2)" "unprognostic (1.67e-2)" "unprognostic (2.43e-2)" "prognostic favorable (6.58e-9)" "unprognostic (2.33e-1)" "unprognostic (9.78e-3)" "unprognostic (4.67e-3)" "unprognostic (7.36e-2)" 158.8 117.7 69.0 103.1 71.2 127.7 108.4 75.5 90.0 90.8 113.9 259.8 292.5 98.2 72.7 157.4 109.7 99.5 559.4 72.4 73.7 240.0 245.1 75.4 120.0 74.1 69.5 114.5 89.7 257.2 39.8 96.5 72.7 95.6 262.8 142.3 133.8 104.3 722.2 85.4 233.6 121.2 65.8 80.9 153.2 55.8 76.5 131.3 107.9 933.2 149.3 153.6 59.8 73.3 173.9 193.1 116.5 66.4 154.3 186.8 169.1 163.8 160.6 177.5 174.5 347.9 177.7 338.9 144.3 170.4 129.8 324.6 222.3 212.7 193.7 151.4 178.4 185.9 166.1 494.3 164.6 249.1 501.2 232.3 229.4 130.3 186.2 169.4 248.1 224.1 217.9 159.1 177.2 230.6 288.6 175.0 124.6 261.1 148.8 310.9 263.6 390.0 285.8 214.6 154.4 114.9 237.2 318.6 190.3 151.6 354.4 264.1 179.3 103.3 98.1 104.0 148.0 126.3 87.2 302.7 188.7 239.8 126.4 80.1 128.7 71.4 80.0 147.8 103.3 96.0 98.3 89.3 153.9 77.9 106.8 97.6 45.9 101.8 148.1 67.6 134.8 157.3 69.0 71.2 75.5 90.0 72.4 73.7 74.1 69.5 72.7 65.8 76.5 73.3 105.5 64.1 52.5 81.9 81.1 90.6 190.8 444.0 74.6 109.1 91.7 79.6 556.2 84.4 194.9 71.7 87.6 238.3 82.6 233.4 455.9 124.5 88.0 72.0 55.7 91.3 113.8 92.4 65.0 109.6 157.6 89.0 144.3 65.8 92.6 99.6 84.3 122.3 195.5 69.0 74.0 224.4 238.0 145.1 100.6 89.9 68.3 104.6 131.6 27.2 162.1 108.0 91.6 60.3 50.7 97.2 214.0 97.0 72.9 114.4 378.0 306.9 110.2 152.6 78.9 94.1 109.5 68.9 56.7 132.0 88.4 278.3 91.3 170.2 358.7 204.3 XPNPEP1 "XPNPEP, XPNPEPL, XPNPEPL1" ENSG00000108039 "X-prolyl aminopeptidase 1" Q9NQW7 10 109864766-109923553 "Enzymes, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025196, HPA030419, HPA030420, HPA030422" Supported Enhanced Cytosol NA NA 810000 "Cluster 27: Non-specific - Gene expression" "Cluster 29: Non-specific - Vesicular transport" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 51: Myeloid cells - Hemostasis" Cytosol "CAB025196: , HPA030419: AB_10598917, HPA030420: AB_10611523, HPA030422: AB_10601783" "unprognostic (3.17e-2)" "unprognostic (2.36e-2)" "unprognostic (1.11e-1)" "unprognostic (2.31e-2)" "unprognostic (2.46e-1)" "unprognostic (2.01e-3)" "prognostic unfavorable (2.12e-5)" "unprognostic (8.03e-2)" "unprognostic (2.10e-2)" "unprognostic (1.88e-1)" "unprognostic (4.89e-2)" "unprognostic (7.61e-2)" "unprognostic (2.43e-2)" "unprognostic (1.34e-2)" "unprognostic (1.74e-1)" "unprognostic (2.40e-1)" "unprognostic (5.18e-2)" 19.7 19.4 13.2 22.9 13.6 23.3 20.1 13.1 14.8 19.7 17.2 32.2 51.7 19.4 22.7 25.1 22.3 27.5 27.9 15.3 13.4 21.4 18.9 19.2 25.4 13.2 12.7 19.8 62.0 24.5 19.2 26.6 13.1 21.7 40.4 18.7 30.4 15.7 28.4 29.5 61.8 28.2 13.2 19.3 24.4 18.1 13.3 19.5 23.6 22.1 28.4 24.6 19.3 13.7 78.1 33.6 52.3 72.1 83.6 77.4 40.2 42.4 85.5 61.8 66.5 65.4 65.2 110.3 35.9 65.0 31.3 40.5 41.7 52.2 60.4 33.0 40.3 74.0 20.5 27.6 58.2 58.3 59.0 76.9 31.8 67.8 60.1 94.6 103.1 70.0 24.3 34.3 80.1 26.3 41.7 36.0 20.6 58.7 35.7 46.1 105.3 19.8 78.5 24.3 15.9 60.5 36.9 23.1 70.6 56.9 28.3 53.6 53.9 25.3 32.9 40.4 38.1 58.4 30.4 92.8 59.4 80.0 20.3 25.7 26.8 11.3 19.5 42.2 13.4 10.6 12.6 17.5 46.4 8.9 8.7 11.7 2.2 30.5 36.8 36.4 15.5 29.6 13.2 13.6 13.1 14.8 15.3 13.4 13.2 12.7 13.1 13.2 13.3 13.7 13.4 6.4 14.4 24.5 14.6 8.9 13.2 32.9 11.4 20.5 12.1 9.7 17.0 18.6 26.3 3.7 6.2 38.2 33.1 34.5 17.6 37.4 6.4 12.3 16.5 18.2 16.8 14.7 18.9 72.9 29.6 22.7 24.5 13.6 11.4 17.0 15.7 12.1 30.9 26.9 25.3 37.1 18.3 20.5 9.6 5.1 18.3 37.5 8.8 15.9 33.5 27.1 24.7 21.6 27.0 54.4 35.1 29.7 18.1 22.5 63.5 31.1 22.8 19.5 13.1 9.8 14.2 17.5 35.9 18.6 8.7 25.2 19.4 30.0 36.5 27.1 XPNPEP2 ENSG00000122121 "X-prolyl aminopeptidase 2" O43895 X 129738949-129769536 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "intestine: 166.6;kidney: 156.0" "Cell type enriched" "Detected in some" 6 "Proximal enterocytes: 475.9" "Cancer enhanced" "Detected in many" "liver cancer: 18.3" "Not detected" "Not detected" "Group enriched" "Detected in many" 4 "gdT-cell: 4.3;intermediate monocyte: 1.4;MAIT T-cell: 1.2;memory CD4 T-cell: 1.3;memory CD8 T-cell: 2.8;naive CD8 T-cell: 2.0;non-classical monocyte: 2.8;T-reg: 1.4" "Group enriched" "Detected in many" 7 "monocytes: 2.8;T-cells: 4.3" "Cell line enhanced" "Detected in some" "ASC diff: 8.2;ASC TERT1: 40.1;HSkMC: 21.1" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA000339, CAB025136, CAB025269, HPA064568" Enhanced Approved "Plasma membrane,Cytosol" "Intracellular and membrane" NA NA 13000000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 45: Enterocytes - Digestion" "Plasma membrane, Cytosol" "CAB025136: , CAB025269: , HPA000339: AB_1858894, HPA064568: " "unprognostic (7.95e-2)" "unprognostic (5.73e-2)" "unprognostic (2.56e-1)" "unprognostic (6.21e-3)" "unprognostic (3.54e-2)" "unprognostic (1.54e-1)" "unprognostic (4.04e-1)" "unprognostic (3.26e-1)" "unprognostic (3.01e-1)" "unprognostic (2.41e-2)" "unprognostic (3.07e-1)" "unprognostic (9.28e-3)" "unprognostic (2.77e-2)" "unprognostic (6.53e-2)" "unprognostic (3.18e-2)" "unprognostic (1.39e-2)" "unprognostic (3.26e-3)" 7.5 0.9 0.1 3.7 0.1 0.2 3.0 0.1 0.1 3.7 0.1 5.5 99.0 2.4 0.1 2.2 6.3 4.3 5.3 0.1 0.1 156.0 23.1 2.1 0.5 0.2 0.1 1.8 0.3 0.3 0.1 1.2 0.1 1.8 6.3 0.0 1.5 0.4 0.5 4.4 166.6 6.0 0.1 0.3 3.4 0.1 0.1 1.0 1.4 2.4 0.4 7.8 4.0 0.1 0.0 0.0 0.5 0.0 8.2 40.1 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 1.2 0.0 0.0 21.1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.3 0.4 0.0 0.0 0.0 0.7 0.0 0.7 0.0 0.0 0.1 1.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.5 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 4.3 1.4 1.2 0.0 1.3 2.8 0.2 0.2 0.4 2.0 0.1 0.0 2.8 0.4 1.4 0.9 0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.1 1.2 0.0 0.0 0.0 0.5 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 1.8 0.0 0.2 0.5 11.4 5.9 0.0 0.0 0.0 0.1 0.3 1.2 0.0 0.2 0.0 0.0 10.0 1.1 0.0 0.0 0.0 0.4 18.5 0.8 0.0 0.3 12.8 0.0 1.0 3.6 0.0 0.0 1.0 1.8 1.0 0.0 0.0 3.1 0.0 0.1 0.0 21.0 0.0 0.1 0.0 475.9 75.1 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.0 1.0 1.2 0.9 0.0 8.4 0.0 XPNPEP3 "APP3, ICP55, NPHPL1" ENSG00000196236 "X-prolyl aminopeptidase 3" Q9NQH7 22 40857077-40932815 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Disease variant, Nephronophthisis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Early spermatids: 232.9;Late spermatids: 306.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000527 Approved Supported Mitochondria,Cytosol NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 34: Spermatids - Unknown function" Mitochondria Cytosol "HPA000527: AB_1079266" "prognostic unfavorable (8.19e-4)" "unprognostic (6.77e-2)" "unprognostic (3.22e-3)" "unprognostic (5.03e-3)" "unprognostic (6.18e-2)" "unprognostic (1.29e-1)" "unprognostic (1.65e-1)" "unprognostic (1.13e-1)" "unprognostic (1.64e-1)" "unprognostic (2.53e-1)" "unprognostic (1.73e-2)" "unprognostic (1.51e-1)" "unprognostic (6.69e-2)" "unprognostic (8.00e-3)" "unprognostic (2.49e-1)" "prognostic unfavorable (6.10e-4)" "unprognostic (1.24e-1)" 2.7 4.9 6.4 1.3 6.3 1.6 2.6 8.3 7.8 2.9 7.1 2.5 14.6 4.7 5.0 2.8 3.7 4.4 5.3 7.8 6.1 3.7 8.2 2.4 2.5 7.2 6.6 3.8 3.6 2.1 3.7 1.5 6.6 2.8 2.2 4.4 3.4 2.5 5.5 5.5 10.1 2.4 5.6 2.8 2.8 3.7 6.7 5.9 3.2 3.5 1.9 3.7 2.8 9.0 2.7 4.1 2.5 5.5 6.3 4.6 2.1 3.3 2.5 1.7 1.7 3.1 1.6 5.2 1.8 6.5 7.8 7.3 4.7 2.4 2.7 3.5 9.7 3.3 9.7 7.5 3.2 6.0 0.5 4.0 3.9 5.7 3.3 2.7 3.3 3.8 2.9 4.8 4.3 4.1 3.1 3.2 1.5 5.0 8.3 3.9 3.3 3.0 5.9 3.6 2.3 1.9 3.9 4.8 3.3 2.6 6.1 2.7 3.2 3.6 3.4 3.4 2.1 4.7 4.0 7.4 5.6 8.5 2.5 2.8 2.5 2.9 2.1 2.5 1.0 3.7 1.2 1.2 1.9 1.9 2.4 1.9 3.6 0.7 6.9 3.8 1.9 2.8 6.4 6.3 8.3 7.8 7.8 6.1 7.2 6.6 6.6 5.6 6.7 9.0 9.6 6.4 17.6 32.0 12.7 13.3 8.0 15.6 9.6 16.0 12.9 13.2 22.5 15.7 14.0 9.2 18.8 21.7 11.0 6.2 15.6 12.2 232.9 37.5 16.6 11.7 13.8 12.0 22.0 17.1 18.7 13.1 12.2 12.0 14.0 17.8 10.8 36.0 14.7 16.8 24.0 9.5 12.2 12.6 15.7 306.8 19.9 11.9 17.8 18.7 7.8 13.0 9.2 19.6 42.3 10.4 9.5 15.4 11.8 7.8 3.5 25.3 38.5 19.8 32.9 14.0 12.7 65.6 34.2 12.2 16.3 20.0 11.0 19.5 8.7 7.6 YME1L1 YME1L ENSG00000136758 "YME1 like 1 ATPase" Q96TA2 10 27110111-27155266 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA066953 Approved Supported "Nuclear bodies,Mitochondria" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" Mitochondria "Nuclear bodies" "HPA066953: AB_2685753" "unprognostic (2.28e-3)" "unprognostic (3.00e-2)" "unprognostic (1.34e-1)" "unprognostic (7.19e-2)" "unprognostic (8.12e-2)" "unprognostic (2.47e-1)" "prognostic unfavorable (8.25e-6)" "unprognostic (7.08e-2)" "unprognostic (2.91e-1)" "unprognostic (9.24e-2)" "unprognostic (9.43e-3)" "unprognostic (1.64e-1)" "unprognostic (1.21e-1)" "unprognostic (1.03e-1)" "unprognostic (5.53e-2)" "unprognostic (1.44e-2)" "unprognostic (7.09e-2)" 48.8 52.6 17.7 51.7 18.4 95.1 47.5 23.3 21.7 52.4 36.4 52.2 46.0 50.3 53.3 59.1 43.7 46.0 61.4 17.8 22.7 54.0 65.5 39.8 56.6 18.2 22.1 50.8 52.0 54.5 33.3 61.1 19.9 48.4 52.4 42.0 44.7 44.5 111.4 40.1 46.3 49.2 16.6 46.4 48.8 51.2 19.7 65.9 62.2 97.7 62.5 56.8 35.0 24.4 146.6 105.3 125.5 62.0 118.3 123.9 100.7 143.3 79.7 139.7 157.6 143.3 171.9 152.1 90.8 154.8 100.5 135.6 152.8 122.6 152.9 143.4 89.0 144.4 91.0 98.3 124.6 100.4 114.5 104.7 143.3 123.4 121.6 122.5 146.7 138.8 173.8 150.5 154.4 95.1 189.1 53.7 97.4 119.3 49.4 160.4 199.7 143.0 107.7 68.2 95.6 121.9 138.4 105.2 138.9 102.8 101.5 115.1 146.9 83.4 117.3 140.8 126.7 75.1 121.9 196.1 119.4 178.8 65.8 195.0 146.4 165.4 147.5 128.5 149.4 143.0 142.4 138.8 121.9 149.7 129.3 136.8 204.0 135.6 143.1 222.6 156.7 155.5 17.7 18.4 23.3 21.7 17.8 22.7 18.2 22.1 19.9 16.6 19.7 24.4 105.4 67.3 81.8 40.5 108.3 70.1 96.7 55.6 92.2 53.1 76.8 90.9 103.6 32.9 66.4 29.5 83.4 61.2 121.0 179.4 15.6 52.2 62.3 141.4 152.5 86.1 50.3 63.1 67.0 48.6 74.4 101.1 136.6 224.3 110.8 75.0 58.5 70.0 73.2 50.5 68.1 121.2 32.6 98.9 133.2 27.0 57.8 125.4 56.9 41.2 63.7 63.8 47.4 66.9 75.2 66.8 109.3 43.2 93.8 83.7 156.5 47.3 70.1 65.7 72.3 156.6 94.5 143.4 57.4 92.5 64.9 94.8 122.1 102.2 104.4 75.0 ZMPSTE24 "FACE-1, HGPS, PRO1, STE24, Ste24p" ENSG00000084073 "Zinc metallopeptidase STE24" O75844 1 40258041-40294180 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006988 Approved NA NA 50000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 1: Thyroid gland - Transcription" "Cluster 43: THP-1 - Innate immune response" "Cluster 10: Non-specific - Unknown function" "HPA006988: AB_1080659" "unprognostic (6.32e-2)" "unprognostic (1.63e-2)" "unprognostic (3.75e-3)" "unprognostic (4.63e-2)" "unprognostic (4.16e-3)" "unprognostic (1.37e-1)" "prognostic unfavorable (5.73e-6)" "unprognostic (1.86e-1)" "unprognostic (1.17e-1)" "unprognostic (1.84e-3)" "unprognostic (4.78e-2)" "unprognostic (7.96e-2)" "unprognostic (5.06e-2)" "unprognostic (3.65e-2)" "unprognostic (2.65e-1)" "prognostic unfavorable (6.34e-4)" "unprognostic (2.71e-2)" 20.5 24.6 16.3 19.9 16.7 5.6 25.5 18.1 22.9 26.2 21.9 28.5 22.2 26.7 27.4 21.7 18.8 25.7 20.6 16.1 18.8 46.0 38.4 21.7 16.8 17.4 17.7 14.3 17.4 53.3 10.2 22.1 18.5 26.3 33.1 10.9 19.6 23.8 16.3 16.3 23.4 32.2 18.7 13.7 21.3 11.0 17.7 15.5 27.5 18.1 23.0 29.4 16.2 18.9 69.3 38.4 35.6 26.1 90.3 71.3 67.0 64.0 60.6 81.7 73.9 35.4 118.8 62.7 41.1 92.1 29.9 71.0 78.4 67.9 97.9 54.4 39.8 59.9 36.0 44.5 45.4 99.3 68.8 45.5 67.4 64.7 28.4 45.4 58.3 27.3 63.0 60.6 80.1 30.2 60.7 28.3 70.0 47.2 42.2 52.2 60.2 77.6 75.2 58.0 38.0 44.6 60.9 155.6 85.9 56.3 55.2 249.1 46.4 68.6 52.5 56.0 78.0 37.1 106.2 49.6 75.6 64.6 79.1 18.9 21.4 14.0 17.6 27.2 22.5 15.0 19.4 19.4 29.4 11.4 16.7 22.9 8.5 29.6 24.3 18.4 24.6 22.7 16.3 16.7 18.1 22.9 16.1 18.8 17.4 17.7 18.5 18.7 17.7 18.9 28.9 38.5 24.1 19.2 20.1 32.0 24.2 41.4 33.0 6.6 35.9 19.0 25.5 54.3 43.0 73.5 0.0 41.4 22.1 44.3 31.3 58.9 3.5 30.7 32.6 31.2 27.6 18.1 16.6 36.9 38.3 36.0 21.9 40.0 21.0 16.6 27.5 64.4 34.0 10.1 13.9 31.0 54.9 33.9 24.5 2.2 28.6 28.6 24.9 11.2 30.5 29.3 19.6 17.6 20.2 44.0 29.3 32.7 31.1 37.7 31.7 42.6 64.2 7.7 0.0 26.8 41.2 7.8 6.4 31.5 27.1 39.0 23.1 28.9 35.6 24.5