Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific nTPM" "RNA single cell type specificity" "RNA single cell type distribution" "RNA single cell type specificity score" "RNA single cell type specific nTPM" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific nTPM" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific nTPM" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific nTPM" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific nTPM" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific nTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific nTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "CCD Protein" "CCD Transcript" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Blood expression cluster" "Tissue expression cluster" "Cell line expression cluster" "Single cell expression cluster" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [nTPM]" "Tissue RNA - adrenal gland [nTPM]" "Tissue RNA - amygdala [nTPM]" "Tissue RNA - appendix [nTPM]" "Tissue RNA - basal ganglia [nTPM]" "Tissue RNA - bone marrow [nTPM]" "Tissue RNA - breast [nTPM]" "Tissue RNA - cerebellum [nTPM]" "Tissue RNA - cerebral cortex [nTPM]" "Tissue RNA - cervix [nTPM]" "Tissue RNA - choroid plexus [nTPM]" "Tissue RNA - colon [nTPM]" "Tissue RNA - duodenum [nTPM]" "Tissue RNA - endometrium 1 [nTPM]" "Tissue RNA - epididymis [nTPM]" "Tissue RNA - esophagus [nTPM]" "Tissue RNA - fallopian tube [nTPM]" "Tissue RNA - gallbladder [nTPM]" "Tissue RNA - heart muscle [nTPM]" "Tissue RNA - hippocampal formation [nTPM]" "Tissue RNA - hypothalamus [nTPM]" "Tissue RNA - kidney [nTPM]" "Tissue RNA - liver [nTPM]" "Tissue RNA - lung [nTPM]" "Tissue RNA - lymph node [nTPM]" "Tissue RNA - medulla oblongata [nTPM]" "Tissue RNA - midbrain [nTPM]" "Tissue RNA - ovary [nTPM]" "Tissue RNA - pancreas [nTPM]" "Tissue RNA - parathyroid gland [nTPM]" "Tissue RNA - pituitary gland [nTPM]" "Tissue RNA - placenta [nTPM]" "Tissue RNA - pons [nTPM]" "Tissue RNA - prostate [nTPM]" "Tissue RNA - rectum [nTPM]" "Tissue RNA - retina [nTPM]" "Tissue RNA - salivary gland [nTPM]" "Tissue RNA - seminal vesicle [nTPM]" "Tissue RNA - skeletal muscle [nTPM]" "Tissue RNA - skin 1 [nTPM]" "Tissue RNA - small intestine [nTPM]" "Tissue RNA - smooth muscle [nTPM]" "Tissue RNA - spinal cord [nTPM]" "Tissue RNA - spleen [nTPM]" "Tissue RNA - stomach 1 [nTPM]" "Tissue RNA - testis [nTPM]" "Tissue RNA - thalamus [nTPM]" "Tissue RNA - thymus [nTPM]" "Tissue RNA - thyroid gland [nTPM]" "Tissue RNA - tongue [nTPM]" "Tissue RNA - tonsil [nTPM]" "Tissue RNA - urinary bladder [nTPM]" "Tissue RNA - vagina [nTPM]" "Tissue RNA - white matter [nTPM]" "Cell RNA - A-431 [nTPM]" "Cell RNA - A549 [nTPM]" "Cell RNA - AF22 [nTPM]" "Cell RNA - AN3-CA [nTPM]" "Cell RNA - ASC diff [nTPM]" "Cell RNA - ASC TERT1 [nTPM]" "Cell RNA - BEWO [nTPM]" "Cell RNA - BJ [nTPM]" "Cell RNA - BJ hTERT+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]" "Cell RNA - CACO-2 [nTPM]" "Cell RNA - CAPAN-2 [nTPM]" "Cell RNA - Daudi [nTPM]" "Cell RNA - EFO-21 [nTPM]" "Cell RNA - fHDF/TERT166 [nTPM]" "Cell RNA - GAMG [nTPM]" "Cell RNA - HaCaT [nTPM]" "Cell RNA - HAP1 [nTPM]" "Cell RNA - HBEC3-KT [nTPM]" "Cell RNA - HBF TERT88 [nTPM]" "Cell RNA - HDLM-2 [nTPM]" "Cell RNA - HEK 293 [nTPM]" "Cell RNA - HEL [nTPM]" "Cell RNA - HeLa [nTPM]" "Cell RNA - Hep G2 [nTPM]" "Cell RNA - HHSteC [nTPM]" "Cell RNA - HL-60 [nTPM]" "Cell RNA - HMC-1 [nTPM]" "Cell RNA - HSkMC [nTPM]" "Cell RNA - hTCEpi [nTPM]" "Cell RNA - hTEC/SVTERT24-B [nTPM]" "Cell RNA - hTERT-HME1 [nTPM]" "Cell RNA - hTERT-RPE1 [nTPM]" "Cell RNA - HUVEC TERT2 [nTPM]" "Cell RNA - JURKAT [nTPM]" "Cell RNA - K-562 [nTPM]" "Cell RNA - Karpas-707 [nTPM]" "Cell RNA - LHCN-M2 [nTPM]" "Cell RNA - MCF7 [nTPM]" "Cell RNA - MOLT-4 [nTPM]" "Cell RNA - NB-4 [nTPM]" "Cell RNA - NTERA-2 [nTPM]" "Cell RNA - OE19 [nTPM]" "Cell RNA - PC-3 [nTPM]" "Cell RNA - REH [nTPM]" "Cell RNA - RH-30 [nTPM]" "Cell RNA - RPMI-8226 [nTPM]" "Cell RNA - RPTEC TERT1 [nTPM]" "Cell RNA - RT4 [nTPM]" "Cell RNA - SCLC-21H [nTPM]" "Cell RNA - SH-SY5Y [nTPM]" "Cell RNA - SiHa [nTPM]" "Cell RNA - SK-BR-3 [nTPM]" "Cell RNA - SK-MEL-30 [nTPM]" "Cell RNA - SuSa [nTPM]" "Cell RNA - T-47d [nTPM]" "Cell RNA - THP-1 [nTPM]" "Cell RNA - TIME [nTPM]" "Cell RNA - U-138 MG [nTPM]" "Cell RNA - U-2 OS [nTPM]" "Cell RNA - U-2197 [nTPM]" "Cell RNA - U-251 MG [nTPM]" "Cell RNA - U-266/70 [nTPM]" "Cell RNA - U-266/84 [nTPM]" "Cell RNA - U-698 [nTPM]" "Cell RNA - U-87 MG [nTPM]" "Cell RNA - U-937 [nTPM]" "Cell RNA - WM-115 [nTPM]" "Blood RNA - basophil [nTPM]" "Blood RNA - classical monocyte [nTPM]" "Blood RNA - eosinophil [nTPM]" "Blood RNA - gdT-cell [nTPM]" "Blood RNA - intermediate monocyte [nTPM]" "Blood RNA - MAIT T-cell [nTPM]" "Blood RNA - memory B-cell [nTPM]" "Blood RNA - memory CD4 T-cell [nTPM]" "Blood RNA - memory CD8 T-cell [nTPM]" "Blood RNA - myeloid DC [nTPM]" "Blood RNA - naive B-cell [nTPM]" "Blood RNA - naive CD4 T-cell [nTPM]" "Blood RNA - naive CD8 T-cell [nTPM]" "Blood RNA - neutrophil [nTPM]" "Blood RNA - NK-cell [nTPM]" "Blood RNA - non-classical monocyte [nTPM]" "Blood RNA - plasmacytoid DC [nTPM]" "Blood RNA - T-reg [nTPM]" "Blood RNA - total PBMC [nTPM]" "Brain RNA - amygdala [nTPM]" "Brain RNA - basal ganglia [nTPM]" "Brain RNA - cerebellum [nTPM]" "Brain RNA - cerebral cortex [nTPM]" "Brain RNA - hippocampal formation [nTPM]" "Brain RNA - hypothalamus [nTPM]" "Brain RNA - medulla oblongata [nTPM]" "Brain RNA - midbrain [nTPM]" "Brain RNA - pons [nTPM]" "Brain RNA - spinal cord [nTPM]" "Brain RNA - thalamus [nTPM]" "Brain RNA - white matter [nTPM]" "Single Cell Type RNA - Adipocytes [nTPM]" "Single Cell Type RNA - Alveolar cells type 1 [nTPM]" "Single Cell Type RNA - Alveolar cells type 2 [nTPM]" "Single Cell Type RNA - Astrocytes [nTPM]" "Single Cell Type RNA - B-cells [nTPM]" "Single Cell Type RNA - Basal keratinocytes [nTPM]" "Single Cell Type RNA - Basal prostatic cells [nTPM]" "Single Cell Type RNA - Basal respiratory cells [nTPM]" "Single Cell Type RNA - Basal squamous epithelial cells [nTPM]" "Single Cell Type RNA - Bipolar cells [nTPM]" "Single Cell Type RNA - Breast glandular cells [nTPM]" "Single Cell Type RNA - Breast myoepithelial cells [nTPM]" "Single Cell Type RNA - Cardiomyocytes [nTPM]" "Single Cell Type RNA - Cholangiocytes [nTPM]" "Single Cell Type RNA - Club cells [nTPM]" "Single Cell Type RNA - Collecting duct cells [nTPM]" "Single Cell Type RNA - Cone photoreceptor cells [nTPM]" "Single Cell Type RNA - Cytotrophoblasts [nTPM]" "Single Cell Type RNA - dendritic cells [nTPM]" "Single Cell Type RNA - Distal enterocytes [nTPM]" "Single Cell Type RNA - Distal tubular cells [nTPM]" "Single Cell Type RNA - Ductal cells [nTPM]" "Single Cell Type RNA - Early spermatids [nTPM]" "Single Cell Type RNA - Endometrial ciliated cells [nTPM]" "Single Cell Type RNA - Endometrial stromal cells [nTPM]" "Single Cell Type RNA - Endothelial cells [nTPM]" "Single Cell Type RNA - Enteroendocrine cells [nTPM]" "Single Cell Type RNA - Erythroid cells [nTPM]" "Single Cell Type RNA - Excitatory neurons [nTPM]" "Single Cell Type RNA - Exocrine glandular cells [nTPM]" "Single Cell Type RNA - Extravillous trophoblasts [nTPM]" "Single Cell Type RNA - Fibroblasts [nTPM]" "Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]" "Single Cell Type RNA - Glandular and luminal cells [nTPM]" "Single Cell Type RNA - granulocytes [nTPM]" "Single Cell Type RNA - Granulosa cells [nTPM]" "Single Cell Type RNA - Hepatic stellate cells [nTPM]" "Single Cell Type RNA - Hepatocytes [nTPM]" "Single Cell Type RNA - Hofbauer cells [nTPM]" "Single Cell Type RNA - Horizontal cells [nTPM]" "Single Cell Type RNA - Inhibitory neurons [nTPM]" "Single Cell Type RNA - Intestinal goblet cells [nTPM]" "Single Cell Type RNA - Ionocytes [nTPM]" "Single Cell Type RNA - Kupffer cells [nTPM]" "Single Cell Type RNA - Langerhans cells [nTPM]" "Single Cell Type RNA - Late spermatids [nTPM]" "Single Cell Type RNA - Leydig cells [nTPM]" "Single Cell Type RNA - Macrophages [nTPM]" "Single Cell Type RNA - Melanocytes [nTPM]" "Single Cell Type RNA - Microglial cells [nTPM]" "Single Cell Type RNA - monocytes [nTPM]" "Single Cell Type RNA - Muller glia cells [nTPM]" "Single Cell Type RNA - NK-cells [nTPM]" "Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]" "Single Cell Type RNA - Oligodendrocytes [nTPM]" "Single Cell Type RNA - Pancreatic endocrine cells [nTPM]" "Single Cell Type RNA - Paneth cells [nTPM]" "Single Cell Type RNA - Peritubular cells [nTPM]" "Single Cell Type RNA - Plasma cells [nTPM]" "Single Cell Type RNA - Prostatic glandular cells [nTPM]" "Single Cell Type RNA - Proximal enterocytes [nTPM]" "Single Cell Type RNA - Proximal tubular cells [nTPM]" "Single Cell Type RNA - Respiratory ciliated cells [nTPM]" "Single Cell Type RNA - Rod photoreceptor cells [nTPM]" "Single Cell Type RNA - Sertoli cells [nTPM]" "Single Cell Type RNA - Skeletal myocytes [nTPM]" "Single Cell Type RNA - Smooth muscle cells [nTPM]" "Single Cell Type RNA - Spermatocytes [nTPM]" "Single Cell Type RNA - Spermatogonia [nTPM]" "Single Cell Type RNA - Squamous epithelial cells [nTPM]" "Single Cell Type RNA - Suprabasal keratinocytes [nTPM]" "Single Cell Type RNA - Syncytiotrophoblasts [nTPM]" "Single Cell Type RNA - T-cells [nTPM]" "Single Cell Type RNA - Theca cells [nTPM]" "Single Cell Type RNA - Undifferentiated cells [nTPM]" "Single Cell Type RNA - Urothelial cells [nTPM]" AANAT SNAT ENSG00000129673 "Aralkylamine N-acetyltransferase" Q16613 17 76453351-76470117 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Biological rhythms, Melatonin biosynthesis" "Acyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "retina: 11.0;testis: 4.7" "Cell type enriched" "Detected in some" 10 "Bipolar cells: 302.1" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 2.5;Daudi: 2.0;SCLC-21H: 3.2;U-266/70: 2.3;U-266/84: 2.7;U-698: 3.6" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA054321 Supported Cytosol "Intracellular and membrane" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 56: Bipolar cells - Visual perception" Cytosol "HPA054321: AB_2682449" "unprognostic (7.89e-2)" "unprognostic (2.62e-1)" "unprognostic (1.41e-1)" "unprognostic (2.44e-1)" "unprognostic (1.83e-2)" "unprognostic (2.03e-2)" "unprognostic (1.05e-2)" "unprognostic (3.09e-1)" "unprognostic (1.01e-2)" "unprognostic (3.61e-1)" "unprognostic (9.30e-2)" "unprognostic (4.19e-1)" "unprognostic (2.81e-7)" "unprognostic (1.04e-1)" "unprognostic (6.00e-2)" "unprognostic (4.47e-2)" "unprognostic (1.34e-2)" 0.1 0.2 0.7 1.6 0.7 1.2 0.0 0.8 1.1 0.1 0.2 0.1 0.1 0.1 0.1 0.3 0.2 0.7 0.1 0.9 0.9 0.3 0.0 0.2 1.5 2.1 1.7 0.2 0.2 0.0 0.3 0.0 2.0 0.1 0.0 11.0 0.1 0.0 0.1 1.4 0.4 0.0 1.2 1.0 0.2 4.7 2.1 0.0 0.4 0.0 0.1 0.2 0.1 1.4 0.5 2.5 0.3 0.2 0.0 0.0 0.2 0.0 0.2 0.1 0.0 0.0 1.7 2.0 0.3 0.0 0.3 0.6 0.0 0.0 0.1 0.0 0.6 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.6 0.2 0.0 1.0 0.2 0.3 0.0 0.1 0.6 0.8 0.2 0.1 0.1 1.1 0.0 0.0 3.2 0.2 0.0 0.1 0.8 0.3 1.5 0.3 0.0 0.0 0.9 0.1 0.0 2.3 2.7 3.6 0.6 0.2 0.4 0.7 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.4 0.0 0.3 0.0 0.0 0.7 0.7 0.8 1.1 0.9 0.9 2.1 1.7 2.0 1.2 2.1 1.4 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 302.1 0.1 0.4 0.3 0.0 0.0 0.0 12.5 0.3 0.2 0.0 0.0 0.0 7.5 0.2 0.1 0.6 1.2 0.0 0.9 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.1 6.7 0.6 0.1 0.0 0.3 0.0 19.4 0.3 0.1 0.0 0.0 0.0 13.2 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.1 0.0 0.4 0.0 30.2 0.0 0.0 0.0 3.1 1.1 0.0 0.0 0.1 0.0 0.1 0.1 0.1 AARS1 "AARS, AlaRS, CMT2N" ENSG00000090861 "Alanyl-tRNA synthetase 1" P49588 16 70251983-70289707 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Protein biosynthesis" "Aminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding" "Charcot-Marie-Tooth disease, Disease variant, Epilepsy, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in some" 6 "Cardiomyocytes: 25.1;Cytotrophoblasts: 63.0;Extravillous trophoblasts: 29.9;Hofbauer cells: 27.1;Syncytiotrophoblasts: 52.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034261, HPA040870, HPA044223" Supported Supported Cytosol NA NA 620000 "Cluster 27: Non-specific - Gene expression" "Cluster 22: Non-specific - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 47: Cytotrophoblasts - Unknown function" Cytosol "CAB034261: AB_1562673, HPA040870: AB_10794995, HPA044223: AB_2678862" "unprognostic (1.98e-2)" "unprognostic (6.87e-2)" "unprognostic (8.02e-2)" "unprognostic (5.72e-2)" "unprognostic (3.58e-1)" "unprognostic (2.50e-2)" "unprognostic (7.99e-2)" "unprognostic (2.36e-1)" "unprognostic (1.99e-1)" "unprognostic (1.76e-1)" "unprognostic (8.33e-2)" "unprognostic (2.92e-1)" "unprognostic (3.42e-2)" "unprognostic (3.75e-2)" "unprognostic (2.05e-3)" "unprognostic (8.22e-2)" "unprognostic (3.83e-3)" 43.7 54.7 60.1 33.4 64.3 7.9 41.4 73.3 88.6 42.1 49.2 48.9 26.0 49.8 49.6 29.5 40.4 22.3 47.9 62.8 71.7 43.6 72.0 45.3 30.0 78.6 68.6 37.3 75.8 74.9 50.1 35.6 84.9 40.0 26.2 59.3 53.3 47.2 62.4 28.8 32.7 47.8 66.3 38.3 51.8 23.8 74.8 36.4 66.6 39.7 35.5 45.9 32.8 83.9 123.7 192.8 52.9 205.7 127.3 115.0 125.7 97.7 135.3 119.7 151.8 162.5 163.2 140.4 127.2 99.3 90.8 137.2 160.5 133.1 170.7 63.2 54.7 135.6 78.0 152.2 348.0 74.4 77.2 133.9 193.8 228.1 508.4 91.4 120.3 209.3 176.0 173.4 91.3 282.0 89.4 85.0 104.3 160.0 108.5 170.4 36.1 317.0 84.7 60.3 67.9 57.3 269.5 62.3 246.1 75.8 197.7 181.3 75.2 85.2 82.9 84.9 78.8 233.8 174.2 258.2 155.4 124.9 175.9 6.5 7.8 2.7 11.9 13.2 13.0 12.8 9.7 11.7 11.9 9.1 11.2 12.2 0.1 22.7 14.1 7.0 8.0 12.6 60.1 64.3 73.3 88.6 62.8 71.7 78.6 68.6 84.9 66.3 74.8 83.9 6.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 25.1 0.0 0.0 0.0 0.0 63.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 3.9 0.0 0.0 0.0 0.0 29.9 4.5 0.0 0.0 0.0 0.0 0.0 0.0 27.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 52.0 0.2 0.0 0.0 0.0 AARS2 "AARSL, bA444E17.1, KIAA1270" ENSG00000124608 "Alanyl-tRNA synthetase 2, mitochondrial" Q5JTZ9 6 44298731-44313347 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Protein biosynthesis" "Aminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding" "Cancer-related genes, Cardiomyopathy, Disease variant, Neurodegeneration, Premature ovarian failure, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035636, HPA061396" Approved Enhanced Mitochondria NA NA "Cluster 44: Non-specific - Transcription" "Cluster 35: Non-specific - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 23: Spermatids - Flagellum & Golgi organization" Mitochondria "HPA035636: AB_10670837, HPA061396: AB_2684502" "unprognostic (1.56e-1)" "unprognostic (3.24e-2)" "unprognostic (2.58e-2)" "unprognostic (2.04e-3)" "unprognostic (2.83e-1)" "unprognostic (1.69e-1)" "unprognostic (8.83e-3)" "unprognostic (5.12e-2)" "unprognostic (3.64e-2)" "unprognostic (1.38e-1)" "unprognostic (2.19e-2)" "unprognostic (1.37e-2)" "unprognostic (1.74e-1)" "unprognostic (1.84e-1)" "unprognostic (1.48e-1)" "unprognostic (1.08e-1)" "unprognostic (2.02e-1)" 4.7 5.2 6.5 5.6 6.2 5.4 4.9 9.4 6.7 7.6 6.7 5.8 6.5 6.1 3.2 9.2 6.4 4.6 6.0 6.8 5.1 5.7 6.9 4.3 6.0 6.1 5.8 8.3 6.5 5.9 6.3 4.1 6.4 7.0 4.1 5.4 6.2 4.3 4.8 7.2 7.9 4.1 5.4 7.2 5.4 3.7 6.0 6.2 6.2 3.3 5.3 5.6 7.4 6.7 14.6 9.9 13.9 23.8 8.1 7.2 18.3 10.9 5.7 11.2 10.6 11.4 7.1 16.3 16.2 4.8 12.2 10.0 14.7 16.0 4.7 10.9 23.7 18.9 10.6 14.5 4.8 17.9 16.0 5.9 9.8 9.0 10.2 7.3 9.5 21.8 21.0 15.4 6.2 16.0 14.2 15.9 9.9 40.3 9.8 16.4 8.7 10.4 6.7 12.7 32.0 11.4 9.4 10.9 15.5 9.7 9.9 21.6 8.4 12.1 13.5 7.6 13.9 8.8 8.7 16.5 6.8 15.9 22.1 2.2 1.1 0.1 1.3 1.3 2.1 1.5 1.9 1.7 1.0 2.9 1.8 1.7 0.2 1.9 1.4 1.3 1.2 1.3 6.5 6.2 9.4 6.7 6.8 5.1 6.1 5.8 6.4 5.4 6.0 6.7 2.6 6.4 3.3 5.2 3.7 0.6 2.1 1.9 4.0 6.6 2.8 2.7 3.5 5.7 2.8 0.0 12.5 5.0 4.9 3.0 0.0 2.3 10.1 3.5 5.4 3.0 0.0 8.2 5.5 0.4 5.0 3.4 5.1 6.2 0.0 5.9 3.9 2.5 3.3 0.0 9.0 2.2 2.0 2.8 1.8 1.0 4.7 2.5 0.0 1.9 3.9 2.0 4.1 3.0 3.6 1.4 0.7 4.5 6.9 1.6 6.3 1.0 3.0 7.1 0.0 4.7 2.8 4.3 6.1 4.4 0.4 5.3 4.1 4.5 3.7 1.6 ABCA4 "ABCR, ARMD2, CORD3, FFM, RP19, STGD, STGD1" ENSG00000198691 "ATP binding cassette subfamily A member 4" P78363 1 93992834-94121148 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Sensory transduction, Transport, Vision" Translocase "Age-related macular degeneration, Cone-rod dystrophy, Disease variant, Retinitis pigmentosa, Stargardt disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 32 "choroid plexus: 144.6;retina: 461.0" "Group enriched" "Detected in some" 12 "Cone photoreceptor cells: 450.4;Rod photoreceptor cells: 482.9" "Cancer enhanced" "Detected in many" "lung cancer: 3.1" "Region enriched" "Detected in some" 6 "hippocampal formation: 9.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 3.1;EFO-21: 6.8;HeLa: 2.3;SK-BR-3: 3.0;SuSa: 3.1" "Low region specificity" "Detected in many" "Not detected" "Not detected" "HPA064420, HPA078826" Enhanced Approved Cytosol NA NA "Cluster 79: Retina - Phototransduction" "Cluster 38: EFO-21 - Unknown function" "Cluster 46: Photoreceptor cells - Phototransduction" Cytosol "HPA064420: , HPA078826: " "unprognostic (1.25e-1)" "unprognostic (3.93e-1)" "unprognostic (3.29e-2)" "unprognostic (7.17e-4)" "unprognostic (1.28e-1)" "unprognostic (3.00e-1)" "unprognostic (1.38e-2)" "prognostic favorable (2.45e-4)" "unprognostic (3.77e-2)" "unprognostic (5.25e-1)" "unprognostic (3.70e-1)" "unprognostic (5.18e-2)" "unprognostic (1.17e-9)" "unprognostic (1.61e-2)" "unprognostic (1.55e-1)" "unprognostic (2.47e-1)" "prognostic unfavorable (2.72e-4)" 0.5 0.0 0.4 0.1 0.3 0.0 0.8 1.1 0.7 0.5 144.6 0.2 2.5 0.1 8.4 0.2 0.4 0.1 0.2 9.3 0.1 8.7 0.9 0.3 0.4 0.4 0.5 0.2 0.0 0.0 0.1 0.6 0.2 0.2 0.1 461.0 0.0 1.4 0.1 2.1 2.9 0.0 0.1 0.1 0.1 1.0 1.4 0.3 0.4 0.0 0.1 0.2 0.1 0.4 0.3 0.0 0.1 0.0 0.0 0.0 3.1 0.1 0.2 0.0 0.1 0.1 0.0 0.0 6.8 0.3 0.1 0.7 0.0 0.0 0.1 0.0 0.0 0.4 2.3 0.7 0.4 0.0 0.0 0.3 0.0 0.3 0.0 0.1 0.6 0.0 0.0 0.1 0.0 0.9 0.5 0.0 1.2 0.0 0.1 0.1 0.2 0.2 0.3 0.3 0.0 0.0 0.6 3.0 0.1 3.1 0.3 0.0 0.1 0.2 1.3 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.3 1.1 0.7 9.3 0.1 0.4 0.5 0.2 0.1 1.4 0.4 1.2 0.0 1.1 1.3 0.0 0.1 0.2 1.7 0.0 27.9 0.5 1.3 1.1 0.0 1.8 7.3 450.4 0.3 0.0 0.0 0.0 0.0 8.8 0.3 0.1 3.1 0.0 0.0 0.4 0.0 1.5 0.2 0.0 0.9 0.0 0.2 1.4 0.3 0.1 10.1 0.6 16.2 0.0 0.3 0.0 21.9 0.0 0.0 0.0 19.7 0.0 37.3 0.0 0.5 0.0 0.0 0.0 0.4 0.0 2.6 1.3 0.4 2.3 482.9 0.0 0.1 0.4 0.0 0.2 0.0 0.0 0.3 0.0 0.3 0.6 0.7 ABCC1 "GS-X, MRP, MRP1" ENSG00000103222 "ATP binding cassette subfamily C member 1" P33527 16 15949138-16143257 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters" Transport "Hydrolase, Translocase" "Cancer-related genes, Deafness, FDA approved drug targets, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Gastric mucus-secreting cells: 49.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "EFO-21: 79.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002380, HPA076011" Uncertain Supported "Plasma membrane,Cell Junctions" NA NA "Cluster 72: Non-specific - Transcription" "Cluster 38: EFO-21 - Unknown function" "Cluster 44: Endometrium - Transcription" "Plasma membrane" "Cell Junctions" "HPA002380: AB_1844432, HPA076011: " "unprognostic (9.97e-2)" "unprognostic (2.06e-1)" "unprognostic (2.05e-2)" "unprognostic (2.94e-1)" "unprognostic (4.89e-2)" "unprognostic (1.15e-1)" "prognostic unfavorable (5.42e-5)" "unprognostic (3.42e-1)" "unprognostic (3.31e-1)" "unprognostic (4.07e-2)" "unprognostic (9.78e-3)" "unprognostic (7.19e-2)" "prognostic unfavorable (1.55e-6)" "unprognostic (1.84e-1)" "unprognostic (1.15e-1)" "unprognostic (1.43e-2)" "unprognostic (1.80e-2)" 10.4 11.6 0.3 4.0 0.2 3.6 8.6 0.3 0.7 10.4 4.1 16.1 1.1 11.0 0.1 22.8 7.0 3.1 11.2 0.3 0.5 8.0 2.3 15.5 4.4 1.1 0.8 8.9 8.9 3.6 7.2 2.0 0.7 15.2 0.7 0.4 9.2 0.9 21.2 9.7 12.4 6.3 0.5 15.7 15.0 13.1 0.6 4.3 21.0 0.1 1.1 15.4 12.8 0.9 4.3 43.7 0.3 11.7 3.2 4.5 0.5 15.4 19.0 13.1 13.8 6.7 34.8 7.0 79.6 29.6 11.0 12.1 3.4 12.4 4.6 22.2 4.4 16.4 22.0 16.3 25.1 5.9 39.5 15.0 9.0 1.1 2.3 3.8 10.2 28.6 17.8 6.8 0.5 5.4 12.0 0.9 3.5 1.8 8.2 41.9 7.8 5.3 0.7 15.2 6.4 11.8 18.9 17.8 3.6 11.9 6.2 0.8 3.5 0.4 2.0 11.4 11.9 13.5 7.4 3.3 6.6 0.6 0.7 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.3 0.7 0.3 0.5 1.1 0.8 0.7 0.5 0.6 0.9 8.6 25.6 5.6 10.7 13.1 8.8 8.5 18.2 9.6 3.1 4.4 3.7 6.0 4.3 14.4 5.5 22.9 0.9 9.8 2.7 3.9 9.1 11.0 15.7 12.9 8.6 18.6 16.0 26.6 6.2 3.2 12.3 49.5 17.8 22.1 16.8 8.6 0.4 8.5 5.0 38.5 6.6 14.2 21.4 9.1 14.3 7.5 12.2 3.6 11.2 10.5 1.2 5.2 12.1 15.9 11.2 4.5 6.8 15.7 18.7 0.5 1.1 9.9 8.8 0.0 6.4 5.1 4.9 6.6 18.1 5.1 0.5 17.4 37.1 3.7 11.6 ABHD12 "ABHD12A, BEM46L2, C20orf22, dJ965G21.2, DKFZP434P106" ENSG00000100997 "Abhydrolase domain containing 12, lysophospholipase" Q8N2K0 20 25294742-25390835 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Lipid metabolism" Hydrolase "Cataract, Deafness, Disease variant, Neuropathy, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Karpas-707: 315.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026866 Uncertain NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 22: Non-specific - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA026866: AB_1844446" "prognostic unfavorable (3.81e-5)" "prognostic favorable (1.30e-5)" "unprognostic (1.32e-1)" "unprognostic (8.74e-2)" "unprognostic (3.67e-2)" "unprognostic (6.56e-2)" "prognostic unfavorable (7.18e-4)" "unprognostic (8.51e-2)" "unprognostic (7.91e-3)" "unprognostic (2.08e-1)" "unprognostic (4.08e-2)" "unprognostic (8.46e-2)" "unprognostic (1.36e-3)" "unprognostic (2.45e-1)" "unprognostic (4.65e-2)" "unprognostic (1.55e-1)" "unprognostic (8.11e-3)" 29.5 33.0 55.7 27.4 67.3 26.5 26.9 70.0 64.7 32.1 35.9 37.0 47.0 25.3 133.1 50.0 24.8 33.4 30.5 77.3 58.2 45.5 29.8 32.6 30.8 70.9 64.6 30.6 117.8 55.3 42.1 29.6 73.3 35.5 36.4 30.8 36.9 39.9 13.3 52.4 52.8 23.6 66.0 22.0 55.0 19.2 71.8 23.4 80.8 14.8 41.5 37.2 35.1 96.9 67.2 148.3 41.6 50.9 79.6 47.1 93.3 97.0 84.5 73.7 84.6 90.1 93.0 21.8 53.3 77.0 155.1 116.5 44.4 56.8 62.8 22.7 41.9 33.3 46.8 128.4 59.3 33.3 71.6 58.7 42.0 85.4 44.1 95.7 33.2 37.8 25.8 315.3 72.8 142.5 51.8 31.0 29.4 77.8 96.8 39.2 95.3 195.0 43.4 145.7 46.6 39.7 75.4 198.9 133.8 72.3 67.4 47.6 44.6 98.3 63.0 57.1 54.0 38.8 36.1 33.4 61.8 38.7 57.3 15.8 18.8 17.3 9.9 17.0 7.5 3.8 10.2 13.7 17.9 5.1 8.9 8.9 3.6 15.4 17.7 17.0 10.4 8.6 55.7 67.3 70.0 64.7 77.3 58.2 70.9 64.6 73.3 66.0 71.8 96.9 20.7 6.4 6.5 19.2 13.8 17.7 32.0 9.8 19.4 34.5 19.6 19.7 16.6 30.0 13.7 27.6 10.4 91.6 22.2 97.0 27.4 33.7 53.0 24.9 18.1 17.5 34.0 14.5 37.7 34.3 95.2 22.9 35.2 28.3 10.2 26.9 15.0 19.5 114.1 42.1 46.0 28.9 20.3 37.8 43.8 107.1 16.1 62.4 33.8 42.2 58.7 44.1 23.7 50.8 67.5 22.9 77.7 20.7 39.3 31.6 126.7 24.6 13.1 23.3 26.3 13.8 19.5 19.9 37.7 27.2 18.3 130.8 18.0 19.6 33.3 35.2 AC022414.1 ENSG00000284762 "Phosphodiesterase 8B" 5 77086732-77427124 "Human disease related genes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "thyroid gland: 12.5" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 2.4;HeLa: 5.3;SCLC-21H: 2.5" HPA036912 Supported NA NA "Cluster 20: HeLa - Mitochondria" "HPA036912: AB_10670377" 1.6 0.8 0.9 0.2 2.0 0.0 0.5 0.4 1.3 1.3 0.1 0.2 0.1 2.1 1.9 0.2 3.6 0.7 1.8 1.2 3.0 1.2 0.4 0.6 0.1 1.5 1.2 1.6 1.1 0.9 1.4 1.7 1.3 0.4 2.7 0.4 1.9 0.1 0.0 0.1 2.5 0.7 0.2 0.8 0.7 1.7 0.2 12.5 0.2 0.4 0.2 2.8 0.1 2.4 0.3 1.0 1.7 0.0 0.0 0.0 0.4 0.3 0.4 0.2 0.2 0.0 0.7 0.1 0.1 0.0 0.4 0.0 0.1 0.0 0.6 0.2 5.3 0.1 0.1 0.1 0.0 0.8 0.1 0.0 0.0 0.0 0.0 1.0 0.0 0.5 0.0 0.8 0.4 0.0 0.6 0.0 0.1 0.7 0.2 0.0 0.2 0.0 2.5 0.6 1.9 1.5 0.5 0.2 1.5 0.1 0.0 0.0 0.3 0.0 0.2 0.3 0.4 0.6 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 2.0 0.4 1.3 1.2 3.0 1.5 1.2 1.7 0.7 1.7 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ACE "ACE1, CD143, DCP1" ENSG00000159640 "Angiotensin I converting enzyme" P12821 17 63477061-63498380 "Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 265.1;testis: 101.9" "Group enriched" "Detected in many" 20 "Early spermatids: 543.6;Late spermatids: 1322.9;Proximal enterocytes: 1172.8" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "basal ganglia: 8.1" "Immune cell enhanced" "Detected in single" "memory B-cell: 1.0" "Low lineage specificity" "Detected in single" "Group enriched" "Detected in many" 4 "ASC TERT1: 63.3;HUVEC TERT2: 33.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002426, CAB002921, HPA029298, HPA069790" Enhanced Approved Vesicles "Secreted to blood" NA NA 104000000 170000000 "Cluster 43: B-cells - Humoral immune response" "Cluster 56: Intestine - Transmembrane transport" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 45: Enterocytes - Digestion" Vesicles "CAB002426: AB_442052, CAB002921: , HPA029298: AB_10960255, HPA069790: AB_2686197" "unprognostic (4.72e-2)" "unprognostic (4.16e-1)" "unprognostic (1.93e-3)" "unprognostic (6.06e-2)" "unprognostic (2.78e-1)" "unprognostic (1.35e-2)" "unprognostic (4.37e-1)" "unprognostic (1.54e-1)" "unprognostic (1.56e-1)" "unprognostic (1.25e-2)" "unprognostic (3.13e-2)" "unprognostic (2.38e-1)" "unprognostic (7.66e-2)" "unprognostic (9.07e-2)" "unprognostic (1.66e-1)" "unprognostic (1.08e-1)" "unprognostic (2.76e-2)" 13.4 4.9 1.7 4.8 8.1 0.1 8.1 0.2 2.5 18.1 0.5 11.2 176.4 8.1 3.5 4.1 6.3 8.2 10.4 1.3 1.0 10.8 1.9 49.0 4.9 1.3 0.9 1.9 6.2 18.7 9.2 11.6 1.3 8.9 6.1 0.4 7.6 23.8 16.1 3.8 265.1 9.6 0.8 2.8 8.3 101.9 2.0 0.8 19.2 10.0 2.1 5.5 3.8 1.1 0.0 0.0 0.0 0.0 2.6 63.3 0.6 2.4 4.7 0.0 0.0 0.9 5.1 1.3 1.8 11.4 0.1 0.0 3.1 0.0 0.0 0.0 1.4 6.6 0.0 0.0 1.4 0.0 0.0 4.2 0.0 0.1 0.0 1.2 33.8 0.0 5.8 0.0 0.1 1.1 0.0 1.4 0.4 11.7 0.7 0.1 0.5 0.9 0.0 0.0 8.2 5.6 0.0 0.0 0.0 1.3 2.9 0.4 0.0 0.1 0.2 0.5 0.1 0.0 0.0 0.0 1.0 0.0 0.5 0.0 0.0 0.0 0.1 0.1 0.2 1.0 0.5 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 1.7 8.1 0.2 2.5 1.3 1.0 1.3 0.9 1.3 0.8 2.0 1.1 50.0 0.0 3.3 0.0 0.5 1.5 2.6 0.1 1.2 4.0 3.6 1.9 2.1 1.5 0.7 0.0 0.0 0.1 0.3 11.9 0.0 5.9 543.6 10.8 8.0 34.7 18.0 0.0 4.7 0.4 0.1 11.5 2.0 36.3 7.0 24.1 3.6 0.8 4.2 0.0 1.8 39.8 0.0 33.7 3.5 1322.9 4.4 13.6 3.6 4.7 0.0 1.8 0.0 1.0 0.2 0.7 40.9 2.6 0.1 4.2 1172.8 21.7 0.0 1.1 0.0 2.0 4.2 13.5 6.4 0.2 0.1 0.1 2.2 0.3 26.2 2.1 ACO2 ACONM ENSG00000100412 "Aconitase 2" Q99798 22 41447830-41529273 "Citric acid cycle related proteins, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Tricarboxylic acid cycle" Lyase "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 567.7;skeletal muscle: 660.4;tongue: 695.8" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 374.2;Proximal tubular cells: 285.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001097 Enhanced Approved Approved Mitochondria NA NA 2000000 "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "HPA001097: AB_1078092" "unprognostic (1.95e-1)" "unprognostic (2.50e-2)" "unprognostic (2.35e-2)" "unprognostic (3.06e-2)" "unprognostic (6.51e-2)" "unprognostic (1.26e-1)" "unprognostic (3.99e-2)" "unprognostic (6.54e-2)" "unprognostic (1.20e-2)" "unprognostic (7.32e-2)" "unprognostic (1.64e-2)" "unprognostic (6.07e-2)" "prognostic favorable (0.00e+0)" "unprognostic (1.46e-2)" "unprognostic (9.60e-2)" "unprognostic (6.45e-2)" "unprognostic (1.12e-2)" 88.8 81.6 154.2 38.6 152.2 32.0 52.4 153.0 190.0 39.5 160.1 94.4 162.9 42.0 26.1 60.4 53.6 36.5 567.7 155.2 153.1 138.9 73.9 40.7 40.5 146.1 145.3 30.8 53.8 233.8 33.6 30.5 147.8 41.2 69.6 46.9 72.0 49.5 660.4 45.5 158.5 43.7 152.5 44.7 110.2 35.1 186.3 38.0 53.7 695.8 43.3 52.5 42.4 159.6 47.2 55.8 56.5 116.3 101.2 69.8 78.7 43.7 60.9 79.0 71.9 81.2 63.5 115.7 72.2 70.6 60.3 109.8 108.8 88.3 42.8 75.8 80.2 51.0 73.7 95.0 86.7 147.8 77.8 120.8 64.4 78.9 83.2 61.7 81.2 61.5 72.9 118.4 65.4 91.7 73.7 47.9 37.0 282.6 115.1 102.3 37.8 162.1 106.8 97.3 37.8 33.9 112.2 128.7 82.0 44.9 74.9 74.7 55.5 60.0 68.7 50.2 45.0 64.7 92.1 80.6 102.0 64.0 66.5 10.3 52.9 18.1 32.0 76.4 29.3 49.4 25.5 34.9 69.0 46.4 29.2 30.8 9.0 39.4 97.1 24.0 41.2 58.6 154.2 152.2 153.0 190.0 155.2 153.1 146.1 145.3 147.8 152.5 186.3 159.6 26.3 25.6 31.8 45.4 49.4 18.7 54.5 102.7 31.3 60.6 28.0 23.2 9.1 64.3 63.5 60.7 81.3 100.3 33.3 190.8 131.0 58.3 14.5 37.2 17.7 26.1 53.2 30.3 28.8 42.6 60.0 24.0 77.5 37.1 40.6 56.7 20.7 64.6 91.5 53.8 34.0 99.1 89.5 35.5 26.4 8.9 24.2 39.2 35.6 7.5 68.3 73.9 34.0 12.1 20.9 43.9 103.5 27.8 63.2 34.4 374.2 285.7 59.2 73.5 59.2 28.6 38.4 26.4 38.2 35.8 16.1 193.2 30.7 54.4 113.6 64.9 ACTG1 "ACTG, DFNA20, DFNA26" ENSG00000184009 "Actin gamma 1" P63261 17 81509413-81523847 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Deafness, Disease variant, Mental retardation, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Basal prostatic cells: 9107.1;Exocrine glandular cells: 8305.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041264, HPA041271" Approved NA NA 4900000000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 22: Epithelial cell types - Mixed function" "HPA041264: AB_2677383, HPA041271: AB_2677386" "unprognostic (3.95e-2)" "unprognostic (3.38e-1)" "prognostic favorable (2.41e-4)" "unprognostic (2.73e-2)" "unprognostic (1.16e-2)" "unprognostic (1.03e-1)" "unprognostic (1.29e-3)" "unprognostic (2.45e-3)" "unprognostic (3.47e-2)" "unprognostic (3.06e-2)" "unprognostic (4.54e-2)" "unprognostic (9.03e-2)" "unprognostic (1.51e-2)" "unprognostic (1.13e-1)" "unprognostic (2.43e-2)" "unprognostic (1.25e-1)" "unprognostic (3.40e-3)" 1548.5 950.4 523.3 1325.4 549.3 1130.2 1158.2 582.8 628.6 1634.2 506.2 1258.5 994.5 1629.9 558.1 2422.2 1315.8 1179.5 666.3 548.5 677.3 905.8 762.8 1516.1 1696.9 652.8 592.5 2046.6 1693.4 608.2 824.5 922.4 629.8 723.8 662.3 293.9 1291.3 643.0 358.4 1455.8 1026.3 739.2 589.8 1034.8 1385.5 438.5 611.8 1347.8 1252.2 270.9 1292.7 1540.3 1571.3 709.7 3652.9 4010.4 4601.5 2275.7 813.0 2758.2 1601.3 4193.6 3154.7 3546.5 2675.5 3699.5 1690.3 2114.0 2566.1 4263.6 2867.3 2049.5 1722.7 3395.6 1727.7 3745.8 2549.8 1724.3 1784.6 3515.1 2165.8 1909.2 2003.4 3599.7 1366.0 3586.4 938.0 4516.4 5237.2 1343.4 331.2 2723.2 3288.0 2677.4 6305.5 2235.8 1970.8 2272.7 2122.3 3520.6 1537.3 1716.3 3385.4 2838.3 1234.4 1284.1 4804.4 969.0 5127.0 1530.7 2192.3 1908.9 5402.3 4755.5 1993.3 2802.6 7012.2 908.3 791.7 1505.4 3808.4 1910.5 2940.1 4240.1 1897.3 3013.3 2108.9 2333.9 2026.4 1297.8 1892.2 2024.3 3012.5 939.2 1391.8 1827.7 1532.7 1355.2 2939.2 1616.5 2980.5 5301.8 523.3 549.3 582.8 628.6 548.5 677.3 652.8 592.5 629.8 589.8 611.8 709.7 1602.0 974.4 558.2 107.1 1285.4 5276.1 9107.1 3827.4 2541.1 493.3 1477.5 1943.4 233.6 825.0 1924.3 1140.3 244.0 2002.6 1886.0 2460.0 1058.5 4368.6 293.0 1028.0 1501.0 1664.2 1914.5 567.0 59.0 8305.0 4361.7 1595.3 2440.4 1433.3 588.7 3067.7 1031.6 517.1 3219.5 267.5 65.7 2206.9 1957.2 1426.0 1807.7 258.5 1718.6 1840.3 1398.1 70.3 4004.3 3402.9 1971.2 78.4 111.9 7194.7 2426.5 1363.9 1369.6 3987.9 1673.2 566.6 950.0 571.1 1360.8 873.0 2277.1 756.5 995.7 3085.9 5371.9 2827.2 1823.7 2394.4 2187.5 6279.2 ACTL6B "ACTL6, BAF53B" ENSG00000077080 "Actin like 6B" O94805 7 100643097-100656448 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Neurogenesis, Transcription, Transcription regulation" "Chromatin regulator" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "brain: 20.7;pituitary gland: 15.3" "Cell type enhanced" "Detected in some" "Bipolar cells: 8.0;Excitatory neurons: 22.1;Horizontal cells: 6.7;Inhibitory neurons: 19.0" "Group enriched" "Detected in some" 11 "glioma: 3.9;pancreatic cancer: 1.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 76 "SCLC-21H: 28.5;SH-SY5Y: 28.7" "Low region specificity" "Detected in all" HPA045126 Uncertain Approved "Nucleoli rim,Mitotic chromosome" Yes NA "Cluster 10: Brain - Neuronal signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoli rim, Mitotic chromosome" "HPA045126: AB_10961265" "unprognostic (3.31e-2)" "unprognostic (6.89e-2)" "unprognostic (4.59e-3)" "unprognostic (4.15e-2)" "unprognostic (1.27e-3)" "unprognostic (4.81e-3)" "unprognostic (6.00e-2)" "unprognostic (8.26e-3)" "unprognostic (1.29e-1)" "unprognostic (4.72e-3)" "unprognostic (1.28e-1)" "unprognostic (3.01e-4)" "unprognostic (1.64e-1)" "unprognostic (6.84e-2)" "unprognostic (2.01e-2)" 0.0 1.8 13.8 0.0 14.5 0.0 0.0 9.4 20.7 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 14.9 8.5 0.0 0.0 0.0 0.0 4.4 1.8 0.0 0.8 0.1 15.3 0.0 4.3 0.0 0.0 4.4 0.0 0.0 0.0 0.0 0.1 0.0 1.7 0.0 0.5 0.6 3.9 0.0 0.0 0.0 0.0 0.0 0.0 11.5 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 28.5 28.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.8 14.5 9.4 20.7 14.9 8.5 4.4 1.8 4.3 1.7 3.9 11.5 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.6 8.0 0.0 0.1 0.3 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.1 0.0 0.0 22.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 6.7 19.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 1.0 0.0 1.2 0.0 3.5 1.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 1.1 0.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 ADAM22 MDC2 ENSG00000008277 "ADAM metallopeptidase domain 22" Q9P0K1 7 87934143-88202889 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion" Receptor "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 7 "brain: 77.2" "Group enriched" "Detected in many" 4 "Excitatory neurons: 286.7;Inhibitory neurons: 304.9;Oligodendrocyte precursor cells: 184.0;Oligodendrocytes: 125.6" "Cancer enhanced" "Detected in many" "glioma: 4.0" "Region enhanced" "Detected in all" "cerebellum: 77.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "Karpas-707: 81.8;SH-SY5Y: 76.9;U-266/84: 33.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA050325, CAB079064" Supported Approved "Cell Junctions" "Intracellular and membrane" NA NA 180000 "Cluster 38: Basophils - Unknown function" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 2: Karpas-707 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Cell Junctions" "CAB079064: , HPA050325: AB_2681087" "unprognostic (1.20e-2)" "unprognostic (8.61e-2)" "unprognostic (3.38e-1)" "unprognostic (1.94e-2)" "unprognostic (2.89e-2)" "unprognostic (3.09e-1)" "unprognostic (7.84e-3)" "unprognostic (1.38e-1)" "unprognostic (1.23e-1)" "unprognostic (1.56e-1)" "unprognostic (3.71e-3)" "unprognostic (1.69e-1)" "unprognostic (3.47e-2)" "unprognostic (4.13e-2)" "unprognostic (2.77e-1)" "unprognostic (1.61e-4)" "unprognostic (4.70e-2)" 2.0 9.1 7.2 0.9 9.2 0.9 1.3 77.2 30.6 6.0 0.0 1.5 0.6 4.6 8.5 0.8 2.4 2.5 2.1 12.2 8.9 3.8 0.2 1.2 2.2 14.4 5.6 3.9 1.0 2.1 3.4 0.3 14.7 11.0 1.4 10.3 0.7 5.1 2.5 1.0 1.1 3.5 2.7 2.0 0.6 1.9 13.8 2.5 3.2 1.2 1.1 1.6 2.6 12.3 2.5 0.7 4.8 5.8 1.4 0.3 3.5 0.1 0.5 0.4 0.5 5.1 8.3 7.4 2.0 0.0 3.5 0.2 7.0 0.1 0.1 20.5 9.0 5.6 5.4 1.5 0.1 6.9 0.1 0.7 0.0 0.1 0.3 6.3 0.5 8.1 0.2 81.8 0.2 6.7 8.9 1.4 11.6 0.6 2.6 5.2 18.8 10.7 0.1 4.1 25.9 76.9 4.1 0.1 0.8 3.7 3.5 0.8 0.1 4.8 3.3 0.9 3.6 18.8 33.2 5.9 4.1 14.2 7.2 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.2 0.0 0.1 0.0 0.2 0.0 0.0 7.2 9.2 77.2 30.6 12.2 8.9 14.4 5.6 14.7 2.7 13.8 12.3 2.4 0.0 2.0 45.7 1.1 0.5 1.7 0.0 2.8 28.4 0.5 0.6 3.1 0.0 0.6 1.8 22.9 0.4 1.9 0.3 1.9 0.0 7.8 2.2 6.9 1.5 1.2 1.3 286.7 0.0 0.1 4.8 1.1 3.3 0.0 0.7 0.7 0.0 0.1 15.2 304.9 0.6 0.0 0.3 0.6 1.5 2.5 0.2 1.8 18.7 0.0 1.4 2.1 184.0 125.6 0.0 3.1 2.6 0.9 0.4 0.3 1.0 0.8 10.9 0.0 2.9 3.2 0.8 1.9 0.4 0.4 0.0 2.2 3.7 1.3 0.3 ADAM9 "CORD9, KIAA0021, MCMP, MDC9, Mltng" ENSG00000168615 "ADAM metallopeptidase domain 9" Q13443 8 38996754-39105445 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, Cone-rod dystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Pancreatic endocrine cells: 179.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "classical monocyte: 4.0" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004000 Approved "Endoplasmic reticulum,Vesicles" "Secreted - unknown location" NA NA 740000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 46: Fibroblasts - ECM organization" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 16: Pancreatic endocrine cells - Mixed function" Vesicles "Endoplasmic reticulum" "HPA004000: AB_1844584" "prognostic unfavorable (1.14e-4)" "prognostic unfavorable (2.25e-4)" "unprognostic (1.32e-3)" "unprognostic (1.27e-1)" "unprognostic (2.86e-1)" "unprognostic (1.40e-1)" "prognostic unfavorable (7.21e-6)" "unprognostic (5.77e-2)" "unprognostic (1.55e-1)" "unprognostic (1.48e-2)" "prognostic unfavorable (2.52e-5)" "unprognostic (5.83e-2)" "prognostic unfavorable (3.99e-4)" "unprognostic (2.80e-1)" "unprognostic (5.76e-2)" "unprognostic (2.27e-1)" "unprognostic (1.23e-2)" 34.2 28.0 7.1 28.8 8.2 2.1 21.5 8.5 8.3 34.8 11.4 32.9 24.5 29.7 15.2 29.7 19.3 47.1 32.1 6.0 8.4 34.9 13.5 51.4 9.7 10.2 7.5 16.8 12.7 52.5 7.8 47.4 9.0 34.9 41.7 18.5 54.9 34.8 24.1 16.1 23.0 51.6 9.4 24.0 44.2 11.1 10.6 5.9 39.9 25.0 13.2 56.1 24.3 11.5 188.3 163.6 63.5 32.6 117.2 374.0 67.0 259.6 382.4 191.7 177.9 82.7 147.1 10.1 86.1 247.2 156.7 79.5 30.8 249.7 373.2 6.9 21.5 12.1 102.8 73.0 226.4 8.9 19.1 287.5 139.2 193.3 212.7 341.0 268.9 15.2 21.5 53.2 406.2 25.0 7.2 4.4 8.3 175.2 46.7 3.8 106.3 27.6 299.3 62.4 6.4 11.5 78.4 90.9 57.8 72.9 67.3 12.0 374.2 109.9 97.9 213.9 124.1 12.9 29.5 7.7 175.8 12.0 72.1 0.3 4.0 0.5 0.1 1.3 0.0 0.0 0.0 0.1 2.5 0.0 0.0 0.1 0.5 0.8 0.6 0.3 0.1 0.9 7.1 8.2 8.5 8.3 6.0 8.4 10.2 7.5 9.0 9.4 10.6 11.5 14.4 48.1 37.0 16.0 3.8 35.9 66.6 78.3 26.7 19.3 23.4 9.8 49.7 24.3 82.1 35.0 20.9 24.1 8.9 44.4 3.9 90.2 14.4 42.1 35.3 20.5 10.7 2.5 47.5 115.4 85.1 42.0 80.5 82.1 5.1 26.4 25.0 7.5 125.9 5.0 38.0 32.2 44.7 60.2 44.8 7.8 28.6 54.7 21.4 33.7 21.8 17.5 1.0 30.7 26.7 179.4 30.6 24.8 5.2 108.7 24.9 41.1 51.9 25.1 13.1 31.3 31.9 4.3 2.5 20.2 21.5 34.3 5.6 11.2 32.7 103.8 ADCY1 "AC1, DFNB44" ENSG00000164742 "Adenylate cyclase 1" Q08828 7 45574140-45723116 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Biological rhythms, cAMP biosynthesis" "Calmodulin-binding, Lyase" "Cancer-related genes, Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 33.7;liver: 19.2;retina: 53.0" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 521.3;Excitatory neurons: 147.2;Inhibitory neurons: 117.9;Rod photoreceptor cells: 174.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "hTERT-HME1: 22.2;SH-SY5Y: 25.5;SK-MEL-30: 30.1;WM-115: 17.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB018364, HPA068274" Uncertain Approved Mitochondria NA NA "Cluster 58: Brain - Synaptic function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 9: Photoreceptor cells - Phototransduction" Mitochondria "CAB018364: AB_2223098, HPA068274: " "unprognostic (9.41e-3)" "unprognostic (7.30e-4)" "unprognostic (9.31e-2)" "unprognostic (2.98e-1)" "unprognostic (4.18e-2)" "unprognostic (3.07e-3)" "unprognostic (1.32e-1)" "unprognostic (7.31e-2)" "unprognostic (1.64e-3)" "unprognostic (2.89e-1)" "unprognostic (7.73e-3)" "unprognostic (1.54e-1)" "unprognostic (4.74e-6)" "unprognostic (2.49e-1)" "unprognostic (7.65e-3)" "unprognostic (2.87e-1)" "unprognostic (2.23e-1)" 1.9 1.8 13.7 0.3 22.4 0.0 4.7 15.4 33.7 5.3 0.0 0.4 0.2 1.8 0.5 0.6 2.0 0.6 2.9 31.9 0.0 1.9 19.2 0.6 0.4 1.2 0.9 0.9 3.3 1.9 2.6 0.4 1.1 2.8 0.4 53.0 0.3 1.2 7.7 0.4 0.3 0.9 0.0 1.7 1.1 2.8 4.0 0.3 2.4 8.5 0.3 0.8 1.3 24.5 0.8 5.9 2.1 3.2 4.1 0.1 4.0 0.2 0.0 0.8 0.3 0.6 0.0 0.0 0.2 0.2 5.8 1.9 3.8 0.3 0.1 10.7 2.7 0.0 0.0 0.6 0.0 0.2 0.1 4.9 2.8 0.5 22.2 0.0 0.1 8.6 0.3 7.0 0.3 7.1 0.0 0.0 8.3 5.1 0.0 0.0 0.0 11.7 0.0 5.7 13.4 25.5 2.1 0.0 30.1 3.1 2.0 3.5 0.0 0.6 4.2 0.5 3.6 0.0 0.0 0.0 0.0 0.0 17.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.7 22.4 15.4 33.7 31.9 0.0 1.2 0.9 1.1 0.0 4.0 24.5 3.5 0.0 0.0 30.7 0.3 0.3 0.6 0.0 0.0 43.8 10.6 5.7 11.4 2.8 0.0 0.0 521.3 0.1 0.3 0.5 1.9 0.0 2.9 1.0 23.1 10.8 31.2 0.0 147.2 0.9 0.2 4.2 0.0 0.7 0.0 0.2 15.7 52.3 0.3 42.1 117.9 1.0 2.0 3.2 0.4 0.7 1.8 0.2 3.6 17.8 0.0 13.8 0.0 63.3 4.0 0.5 0.1 7.5 0.1 2.6 0.0 0.4 0.0 174.4 0.0 2.3 8.8 0.5 6.8 0.1 0.1 0.0 0.6 0.6 0.6 0.3 ADCY5 AC5 ENSG00000173175 "Adenylate cyclase 5" O95622 3 123282296-123449090 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "cAMP biosynthesis" Lyase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 97.7;heart muscle: 105.2" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 75.5;Inhibitory neurons: 44.0;Oligodendrocytes: 89.7;Paneth cells: 59.6;Peritubular cells: 73.7;Sertoli cells: 65.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "MCF7: 15.5;RPMI-8226: 2.7;RPTEC TERT1: 5.2" "Region enriched" "Detected in all" 5 "basal ganglia: 388.0" "Region enriched" "Detected in all" 6 "basal ganglia: 155.9" "HPA017730, HPA077682" Uncertain Enhanced "Intermediate filaments" NA NA "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 54: Cardiomyocytes - Muscle contraction" "Intermediate filaments" "HPA017730: AB_1844595, HPA077682: AB_2686851" "unprognostic (3.55e-2)" "unprognostic (1.01e-3)" "unprognostic (7.61e-3)" "unprognostic (2.05e-2)" "unprognostic (1.25e-1)" "unprognostic (1.26e-2)" "unprognostic (1.48e-1)" "unprognostic (7.61e-2)" "unprognostic (2.49e-2)" "unprognostic (2.34e-1)" "unprognostic (7.27e-3)" "unprognostic (2.64e-2)" "prognostic favorable (7.46e-6)" "unprognostic (1.81e-2)" "unprognostic (5.65e-2)" "unprognostic (3.19e-2)" "unprognostic (5.97e-4)" 18.9 3.3 25.5 4.9 97.7 0.0 10.6 13.9 43.9 9.8 0.0 35.1 5.2 14.7 5.7 18.8 12.7 10.0 105.2 25.8 15.9 12.8 3.3 4.1 2.3 20.5 18.3 13.2 7.5 0.8 14.3 6.1 17.4 19.8 5.6 4.5 4.0 21.5 2.7 2.6 13.0 18.2 10.8 6.5 21.2 8.2 34.4 1.3 1.9 5.8 3.0 23.2 7.8 30.1 0.0 0.6 1.3 0.1 0.1 0.1 0.3 0.0 0.0 0.3 0.0 0.1 0.1 0.0 0.3 0.2 2.3 0.5 0.6 0.0 0.0 0.1 0.8 0.0 0.2 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 15.5 0.0 0.0 0.8 0.0 0.1 0.0 0.3 2.7 5.2 0.5 1.8 1.6 0.0 0.5 0.1 1.7 0.0 0.1 0.0 0.1 1.2 0.1 0.2 0.1 0.6 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 25.5 97.7 13.9 43.9 25.8 15.9 20.5 18.3 17.4 10.8 34.4 30.1 0.3 0.0 0.0 8.1 0.1 0.3 0.1 0.2 0.0 21.8 0.4 5.8 75.5 8.6 0.0 7.3 0.0 1.4 0.0 2.6 0.0 15.9 0.9 1.5 7.1 1.8 0.0 0.0 34.0 6.9 4.0 5.2 0.0 4.0 0.0 4.6 3.9 0.1 0.3 0.0 44.0 0.3 0.0 0.0 0.3 3.0 20.5 0.1 0.0 6.5 1.0 1.0 0.0 19.1 89.7 0.4 59.6 73.7 0.0 0.1 0.3 0.8 0.0 2.2 65.7 0.6 21.4 0.8 6.3 0.2 0.9 12.4 0.2 1.0 2.0 0.1 ADD3 ADDL ENSG00000148700 "Adducin 3" Q9UEY8 10 109996368-110135565 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Actin-binding, Calmodulin-binding" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 449.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC diff: 313.2;ASC TERT1: 292.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009797, HPA035696" Supported Supported "Plasma membrane" NA NA 260000 "Cluster 2: Granulocytes - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane" "CAB009797: AB_2223583, HPA035696: AB_2674740" "unprognostic (2.66e-1)" "unprognostic (2.63e-2)" "unprognostic (1.46e-3)" "unprognostic (1.64e-1)" "unprognostic (2.65e-2)" "unprognostic (1.75e-2)" "unprognostic (1.57e-3)" "unprognostic (6.42e-2)" "unprognostic (5.73e-2)" "unprognostic (2.37e-2)" "unprognostic (7.58e-2)" "unprognostic (9.12e-2)" "unprognostic (2.34e-3)" "unprognostic (1.36e-1)" "unprognostic (4.03e-1)" "unprognostic (3.68e-2)" "unprognostic (5.92e-2)" 57.7 21.7 105.6 38.8 97.2 37.5 89.4 88.6 129.3 57.6 65.9 58.2 71.9 24.9 62.4 39.0 47.6 72.0 59.9 113.3 108.1 102.7 27.8 38.4 70.9 107.3 94.8 46.4 67.9 18.8 25.3 36.6 102.0 32.7 66.0 99.4 59.1 31.8 9.6 33.6 85.4 23.9 105.2 40.0 63.7 51.5 95.6 87.4 87.7 25.6 65.4 42.3 40.1 122.4 29.2 6.0 41.7 19.8 313.2 292.1 17.7 41.2 110.9 25.4 49.9 60.3 90.6 89.9 45.2 63.9 26.4 10.0 37.3 27.1 39.5 9.0 46.5 8.8 28.5 45.9 35.5 30.5 66.0 142.5 12.9 63.3 2.6 96.4 37.8 109.9 23.5 48.7 46.7 0.8 32.3 31.0 25.8 69.2 15.3 27.7 58.2 4.8 65.7 14.2 6.1 67.9 27.6 8.9 66.5 62.2 10.7 11.4 9.5 16.0 42.0 33.5 9.1 68.9 31.5 82.7 47.8 16.2 27.7 139.5 29.6 98.0 68.8 26.5 55.7 51.4 72.9 59.1 24.8 42.9 83.2 67.6 47.1 73.4 32.6 16.3 73.3 94.9 105.6 97.2 88.6 129.3 113.3 108.1 107.3 94.8 102.0 105.2 95.6 122.4 67.3 22.4 52.9 449.2 110.6 55.7 35.9 77.4 38.7 26.8 56.0 34.4 128.2 74.4 85.5 36.8 60.5 55.6 112.7 125.2 60.7 27.2 51.4 70.3 76.0 77.7 102.4 32.6 83.4 61.1 12.1 182.4 100.9 56.0 26.0 18.8 126.7 12.2 25.7 116.1 141.1 71.6 48.8 88.5 41.1 25.7 226.5 66.3 58.7 70.3 65.3 339.0 151.4 236.8 279.6 59.8 167.1 251.3 68.4 38.4 135.2 162.2 151.9 121.7 65.7 27.6 36.2 122.7 62.1 53.2 50.6 22.3 111.5 30.9 166.7 98.6 ADGRV1 "DKFZp761P0710, FEB4, GPR98, KIAA0686, MASS1, USH2C, VLGR1" ENSG00000164199 "Adhesion G protein-coupled receptor V1" Q8WXG9 5 90529344-91164437 "Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Sensory transduction, Vision" "G-protein coupled receptor, Hydrolase, Receptor, Transducer" "Deafness, Retinitis pigmentosa, Usher syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 11 "adrenal gland: 533.0" "Cell type enriched" "Detected in many" 8 "Astrocytes: 2207.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "AF22: 15.5;HAP1: 23.0;K-562: 9.8;NTERA-2: 11.6;SCLC-21H: 11.1;SuSa: 15.0;U-266/70: 13.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA067503 Approved Approved "Lipid droplets" NA NA "Cluster 24: B-cells - Unknown function" "Cluster 17: Adrenal gland - Steroid metabolism" "Cluster 12: NES - Nervous system development" "Cluster 64: Astrocytes - Nervous system maintenance" "Lipid droplets" "HPA067503: AB_2685856" "unprognostic (1.29e-1)" "unprognostic (3.02e-1)" "unprognostic (3.69e-2)" "unprognostic (1.38e-1)" "unprognostic (4.01e-2)" "unprognostic (2.61e-1)" "unprognostic (3.76e-2)" "unprognostic (1.62e-3)" "unprognostic (1.48e-2)" "unprognostic (1.87e-1)" "unprognostic (3.95e-3)" "unprognostic (7.50e-3)" "unprognostic (9.73e-7)" "unprognostic (1.87e-2)" "unprognostic (5.24e-2)" "unprognostic (3.48e-2)" "unprognostic (7.14e-2)" 0.0 533.0 36.9 0.0 47.8 0.6 3.6 12.7 40.3 0.9 22.4 1.0 0.3 0.1 0.7 2.4 0.2 12.3 0.2 39.1 11.6 21.5 42.3 2.1 0.0 9.4 12.8 0.2 1.5 0.8 15.1 4.1 9.4 1.3 1.0 18.2 2.3 0.2 0.2 2.1 0.5 0.0 7.3 0.3 1.1 1.4 18.3 0.8 17.5 0.0 0.4 10.4 1.9 26.1 0.5 2.1 15.5 0.0 0.0 0.1 0.2 0.3 0.1 0.0 0.0 1.7 0.2 0.3 0.4 0.0 0.4 0.2 23.0 0.2 0.0 1.0 4.3 4.1 2.0 1.4 0.0 0.3 0.1 0.0 4.8 0.0 0.1 0.1 0.0 0.1 9.8 2.6 0.0 2.1 0.1 0.2 11.6 2.9 4.2 0.0 0.4 2.1 0.0 0.5 11.1 2.7 3.4 2.2 0.2 15.0 5.9 0.0 0.8 0.4 1.9 0.5 1.1 13.4 4.1 0.6 0.7 0.2 0.0 3.2 0.9 2.8 1.0 0.7 1.7 1.5 1.1 1.4 0.5 2.9 1.7 0.9 4.6 1.1 0.5 1.2 1.6 0.2 36.9 47.8 12.7 40.3 39.1 11.6 9.4 12.8 9.4 7.3 18.3 26.1 0.4 25.6 26.5 2207.3 0.0 0.0 6.1 0.0 1.8 28.0 15.5 7.4 2.4 2.8 5.6 5.5 264.8 3.0 0.4 0.6 1.9 1.9 43.5 3.3 0.3 1.1 7.3 0.0 54.0 4.2 2.6 1.1 4.6 1.9 0.0 6.7 0.0 12.4 0.2 10.1 21.9 0.4 0.0 0.8 0.0 54.8 0.6 0.5 0.0 51.5 1.2 8.9 1.0 40.2 7.4 1.7 1.2 0.4 0.1 2.1 0.1 24.2 7.3 84.4 0.0 0.3 0.4 3.6 4.5 2.9 0.0 4.1 0.6 0.2 1.2 9.0 AFG3L2 "SCA28, SPAX5" ENSG00000141385 "AFG3 like matrix AAA peptidase subunit 2" Q9Y4W6 18 12328944-12377227 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004479, HPA004480" Enhanced Supported Mitochondria NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 8: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" Mitochondria "HPA004479: AB_1078109, HPA004480: AB_1078108" "unprognostic (1.11e-1)" "unprognostic (7.49e-2)" "unprognostic (1.67e-1)" "prognostic unfavorable (8.68e-4)" "unprognostic (1.31e-1)" "unprognostic (5.06e-3)" "unprognostic (1.61e-1)" "unprognostic (2.33e-1)" "unprognostic (5.35e-2)" "unprognostic (1.54e-2)" "unprognostic (4.05e-2)" "unprognostic (3.00e-2)" "prognostic favorable (6.05e-14)" "unprognostic (5.90e-2)" "unprognostic (9.41e-2)" "unprognostic (5.74e-3)" "unprognostic (2.22e-1)" 26.1 25.9 16.4 21.9 17.0 32.4 29.2 18.2 19.0 24.1 30.8 60.8 79.9 22.1 17.5 41.5 23.8 18.3 88.0 17.0 18.7 62.7 51.0 21.8 23.7 17.7 16.6 24.1 41.1 76.0 18.6 23.5 18.8 24.6 54.1 20.3 30.8 24.4 145.4 29.8 58.7 25.4 15.8 18.5 39.1 18.5 19.0 24.3 39.2 155.8 31.0 30.9 19.6 17.6 56.5 56.6 39.7 44.8 45.2 48.6 52.7 61.9 61.1 86.6 63.1 88.1 34.1 161.3 66.3 56.6 76.8 55.6 101.4 71.3 70.3 38.1 43.5 48.5 59.3 83.5 61.1 185.0 69.8 54.3 76.3 82.1 107.7 47.8 64.0 57.0 111.3 92.8 43.6 89.0 66.7 58.5 55.3 277.4 41.9 74.0 125.1 135.2 74.9 123.6 73.7 51.3 97.0 103.8 90.0 50.5 47.8 84.5 49.0 102.4 88.6 98.7 81.7 64.7 80.7 104.1 56.2 71.4 48.0 3.8 16.5 12.4 11.6 17.6 13.9 14.0 13.8 17.9 21.8 10.3 17.2 20.2 1.1 28.4 16.2 11.5 9.5 13.4 16.4 17.0 18.2 19.0 17.0 18.7 17.7 16.6 18.8 15.8 19.0 17.6 24.3 41.7 49.2 23.2 36.6 22.2 45.3 21.5 42.7 50.2 36.5 36.2 74.9 50.1 28.1 35.0 50.1 58.5 29.1 85.2 72.4 39.5 5.5 37.8 52.3 27.7 39.1 61.0 21.1 37.4 37.9 31.2 53.5 46.1 14.5 41.3 21.8 85.6 37.0 30.3 26.8 82.6 18.3 32.6 14.4 5.5 32.9 34.2 23.2 12.2 27.6 26.9 40.2 14.1 17.7 47.8 43.1 30.1 38.8 43.1 88.7 100.0 22.1 58.3 26.3 53.6 26.9 50.9 65.0 75.8 31.3 92.8 28.4 60.8 94.9 38.2 AGBL1 "CCP4, FLJ32310" ENSG00000273540 "ATP/GTP binding protein like 1" Q96MI9 15 86079871-87049169 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Corneal dystrophy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 10 "skeletal muscle: 7.8;tongue: 23.2" "Cell type enhanced" "Detected in some" "Alveolar cells type 2: 16.7;Astrocytes: 28.7;Excitatory neurons: 15.6;Inhibitory neurons: 25.6;Oligodendrocyte precursor cells: 47.3" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 68: Oligodendrocytes - Mixed function" "unprognostic (3.70e-2)" "unprognostic (4.46e-2)" "unprognostic (1.06e-1)" 0.0 0.0 0.6 0.0 1.4 0.0 0.0 0.0 0.7 0.0 0.2 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 1.0 0.3 0.0 0.0 0.7 0.0 1.0 0.8 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.1 0.7 0.0 7.8 0.0 0.0 0.0 0.9 0.0 0.0 0.1 0.4 0.0 0.0 23.2 0.0 0.0 0.0 0.4 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 1.4 0.0 0.7 1.0 0.3 1.0 0.8 0.3 0.9 0.4 0.4 0.0 3.2 16.7 28.7 0.0 0.0 0.1 0.0 0.0 1.7 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.1 0.0 0.0 15.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 25.6 0.0 0.0 0.0 0.0 2.3 0.0 0.1 0.0 1.9 0.0 0.0 0.0 47.3 6.9 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 5.2 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.1 AGBL5 "CCP5, FLJ21839" ENSG00000084693 "ATP/GTP binding protein like 5" Q8NDL9 2 27042364-27070622 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in all" 4 "parathyroid gland: 49.9;testis: 192.9" "Group enriched" "Detected in many" 6 "Early spermatids: 302.7;Late spermatids: 338.0;Spermatocytes: 156.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030981 Uncertain Supported "Microtubules,Cytokinetic bridge,Cytosol" Yes No "Cluster 34: Basophils - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" "Cytokinetic bridge" "Microtubules, Cytosol" "HPA030981: AB_10611673" "unprognostic (1.29e-2)" "unprognostic (8.70e-2)" "unprognostic (2.26e-1)" "unprognostic (3.13e-3)" "unprognostic (1.95e-1)" "unprognostic (1.07e-1)" "prognostic unfavorable (6.87e-5)" "unprognostic (1.86e-1)" "unprognostic (4.34e-1)" "unprognostic (6.20e-2)" "unprognostic (1.28e-1)" "unprognostic (1.20e-1)" "unprognostic (3.41e-2)" "unprognostic (5.56e-2)" "unprognostic (2.05e-1)" "unprognostic (1.69e-2)" "unprognostic (4.50e-2)" 8.8 16.7 8.4 8.0 7.4 13.6 12.4 7.8 8.2 14.4 9.5 16.2 8.8 14.0 26.0 18.3 20.8 14.3 12.7 7.3 11.3 22.5 7.2 11.2 10.7 8.3 7.8 14.4 15.0 49.9 12.5 11.2 8.9 15.2 11.5 16.3 21.2 16.5 7.1 20.5 9.9 14.6 6.1 8.5 11.8 192.9 9.1 15.6 28.5 6.5 8.6 14.9 7.3 7.5 55.0 34.7 55.4 37.2 11.6 23.0 62.9 10.9 23.5 30.9 31.9 30.2 40.5 30.3 34.0 18.9 43.4 24.6 44.8 49.4 33.9 25.9 66.8 44.5 42.0 65.7 23.6 21.6 14.4 24.4 36.7 27.1 22.0 46.9 32.8 43.5 38.9 23.8 30.3 21.5 63.2 32.3 39.4 39.4 23.7 64.5 62.9 48.0 31.9 13.6 37.1 53.6 21.5 16.7 35.0 53.9 24.9 16.3 16.4 28.6 39.2 13.8 23.9 47.7 27.2 62.4 31.8 24.4 26.1 8.8 1.8 4.5 3.3 1.1 2.5 4.6 4.1 4.6 4.1 2.3 3.6 2.2 1.1 8.5 0.7 2.3 2.8 3.8 8.4 7.4 7.8 8.2 7.3 11.3 8.3 7.8 8.9 6.1 9.1 7.5 3.6 0.0 10.1 5.2 6.3 3.3 8.3 7.2 13.6 5.7 8.6 6.7 6.7 10.0 6.8 9.2 0.0 14.7 1.8 5.9 19.6 8.3 302.7 13.0 3.9 4.9 2.4 11.6 7.9 6.0 7.9 6.4 5.6 5.8 1.3 14.1 6.4 4.1 5.2 0.0 9.1 8.4 6.1 3.1 3.5 338.0 10.5 8.0 7.2 6.5 4.9 6.8 0.0 10.1 10.1 5.0 7.6 11.3 17.1 6.0 6.3 25.0 10.7 10.0 0.0 4.2 7.0 156.8 41.2 16.3 2.7 8.3 5.0 9.4 8.6 10.5 AGK "FLJ10842, MULK" ENSG00000006530 "Acylglycerol kinase" Q53H12 7 141551278-141655244 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase" "Cardiomyopathy, Cataract, Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 43.4;Inhibitory neurons: 43.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "NK-cell: 97.3" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020959, HPA053471" Supported Supported Vesicles,Mitochondria "Intracellular and membrane" NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 25: RPMI-8226 - Immune response" "Cluster 63: NK-cells & T-cells - Immune response" Mitochondria Vesicles "HPA020959: AB_1854206, HPA053471: AB_2682164" "unprognostic (1.11e-1)" "unprognostic (1.43e-1)" "unprognostic (2.79e-1)" "unprognostic (1.28e-2)" "unprognostic (9.47e-3)" "unprognostic (5.43e-2)" "unprognostic (2.15e-2)" "unprognostic (3.68e-2)" "unprognostic (2.03e-1)" "unprognostic (3.43e-2)" "unprognostic (1.14e-1)" "unprognostic (6.24e-3)" "unprognostic (7.90e-2)" "unprognostic (9.29e-2)" "unprognostic (9.65e-2)" "unprognostic (3.30e-1)" "unprognostic (1.18e-1)" 10.1 14.7 9.4 8.5 10.9 5.6 11.9 8.3 12.8 11.5 10.2 11.8 5.9 11.7 14.5 12.2 12.2 7.8 30.4 11.1 10.8 15.7 14.1 11.6 12.1 8.0 8.8 11.3 10.1 21.5 13.7 10.0 9.0 12.8 13.1 12.7 13.7 11.4 8.6 9.6 12.0 15.4 8.2 16.6 12.2 6.6 10.0 14.0 12.7 10.0 14.7 10.8 11.5 9.0 23.7 25.6 26.7 21.8 21.2 29.4 16.2 23.5 29.3 44.5 50.9 24.7 18.3 26.3 24.0 26.8 40.5 18.7 41.6 32.8 51.0 33.8 32.7 26.1 10.7 18.7 34.1 15.6 12.5 29.9 26.9 36.3 33.1 19.8 34.1 32.3 36.3 36.9 25.3 24.6 47.3 9.1 25.6 19.9 32.4 29.2 4.2 80.1 33.1 20.8 23.3 29.6 24.6 29.7 27.1 26.1 16.3 20.2 19.5 18.9 14.1 23.8 38.1 29.5 31.9 14.4 30.7 9.1 50.4 0.4 7.1 1.2 22.1 13.9 15.3 10.8 17.3 26.0 16.2 6.5 12.8 23.5 1.2 97.3 8.2 6.3 18.9 15.7 9.4 10.9 8.3 12.8 11.1 10.8 8.0 8.8 9.0 8.2 10.0 9.0 8.4 0.0 6.0 22.5 11.4 3.1 5.6 7.9 5.2 11.8 5.5 5.1 18.1 2.8 6.6 12.9 8.4 15.7 15.8 3.0 9.8 6.6 9.9 7.4 9.0 7.5 0.0 11.8 43.4 6.9 8.2 7.7 10.7 6.6 8.2 9.9 4.2 4.1 7.0 15.2 43.0 3.9 12.2 5.1 4.9 12.0 6.8 5.6 7.2 26.2 12.4 11.2 27.8 38.7 37.9 6.1 2.1 10.5 22.1 2.9 2.4 8.2 7.6 17.4 0.0 6.2 8.0 6.2 4.9 11.3 2.7 9.2 15.0 14.2 5.6 3.8 AGRN AGRIN ENSG00000188157 Agrin O00468 1 1020120-1056118 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins, Transporters" Differentiation "Developmental protein" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 94.5;Collecting duct cells: 156.3;Ductal cells: 91.2;Pancreatic endocrine cells: 87.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CAPAN-2: 205.3;EFO-21: 236.9;HaCaT: 210.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040090 Approved Approved "Plasma membrane,Cytosol" "Secreted to extracellular matrix" NA NA 20000000 "Cluster 7: Kidney - Transmembrane transport" "Cluster 38: EFO-21 - Unknown function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Cytosol "Plasma membrane" "HPA040090: AB_10805603" "unprognostic (8.04e-2)" "unprognostic (8.25e-3)" "unprognostic (1.42e-3)" "unprognostic (1.23e-1)" "unprognostic (3.26e-2)" "unprognostic (2.41e-2)" "prognostic unfavorable (4.62e-4)" "unprognostic (2.82e-3)" "unprognostic (1.32e-1)" "unprognostic (3.33e-2)" "unprognostic (9.49e-3)" "unprognostic (1.06e-1)" "unprognostic (8.46e-2)" "unprognostic (8.49e-2)" "unprognostic (2.07e-2)" "unprognostic (4.08e-1)" "unprognostic (1.31e-2)" 11.4 2.7 8.7 4.3 5.5 2.0 14.7 0.1 13.9 14.4 8.9 10.9 7.9 13.7 1.8 15.6 14.6 7.3 9.9 5.8 0.0 44.0 13.3 19.8 1.6 16.0 1.4 5.5 28.0 3.9 8.3 5.1 6.1 14.4 1.5 0.8 24.8 8.2 4.2 16.5 9.6 2.9 2.2 6.3 13.4 9.7 7.9 2.6 34.7 2.0 1.6 16.2 11.6 9.9 124.3 75.1 11.1 42.7 2.4 3.0 122.1 61.4 19.6 39.7 24.5 60.6 205.3 2.3 236.9 9.6 19.3 210.1 4.1 75.6 4.7 4.4 28.6 0.2 102.1 54.2 17.1 1.8 23.1 10.5 32.2 12.6 27.7 55.9 7.2 1.7 25.7 0.7 3.5 93.0 0.8 17.6 28.4 39.7 54.5 20.1 27.0 18.5 70.0 51.4 2.4 25.9 124.8 129.1 121.9 12.7 114.8 7.4 107.8 47.7 169.0 6.4 50.6 1.2 0.6 3.5 30.4 10.8 13.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.7 5.5 0.1 13.9 5.8 0.0 16.0 1.4 6.1 2.2 7.9 9.9 27.4 25.6 8.8 15.0 2.2 15.0 9.2 94.5 19.9 1.4 32.7 39.2 3.1 61.5 42.0 156.3 8.4 1.6 0.9 29.9 1.9 91.2 0.4 37.2 14.0 29.0 6.7 1.7 23.1 16.9 4.8 8.7 17.9 62.7 2.5 7.2 21.8 13.1 4.1 5.0 7.8 11.6 36.7 2.9 10.1 1.0 5.6 4.3 24.9 12.2 15.6 10.5 0.0 15.1 29.6 87.3 17.7 2.6 0.6 22.3 18.1 16.0 33.0 5.3 6.6 3.3 23.3 0.8 11.4 11.7 6.0 1.2 2.9 2.3 18.3 21.2 AHR bHLHe76 ENSG00000106546 "Aryl hydrocarbon receptor" P35869 7 16916359-17346152 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Biological rhythms, Cell cycle, Transcription, Transcription regulation" "Activator, DNA-binding, Receptor, Repressor" "Cancer-related genes, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Langerhans cells: 262.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "hTCEpi: 71.0;hTERT-HME1: 73.8;OE19: 61.2;RT4: 63.2" "CAB005072, HPA029722, HPA029723" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 85: Liver - Metabolism" "Cluster 30: Epithelial cell lines - Translation" "Cluster 41: Macrophages - Immune response" Cytosol Nucleoplasm "CAB005072: AB_633731, HPA029722: AB_10599189, HPA029723: AB_10599025" "unprognostic (1.29e-2)" "unprognostic (1.21e-2)" "unprognostic (2.13e-1)" "unprognostic (1.39e-2)" "unprognostic (7.28e-2)" "unprognostic (1.22e-1)" "unprognostic (1.44e-1)" "unprognostic (3.39e-1)" "unprognostic (4.32e-2)" "unprognostic (9.98e-2)" "unprognostic (1.24e-3)" "unprognostic (2.89e-1)" "unprognostic (7.53e-3)" "unprognostic (2.00e-1)" "unprognostic (2.82e-3)" "unprognostic (3.25e-2)" "unprognostic (9.45e-2)" 22.3 15.0 1.4 25.8 2.7 44.1 19.5 1.4 2.8 14.5 2.3 13.7 16.4 8.8 7.0 17.4 10.5 33.7 9.5 1.9 1.3 7.1 45.0 37.6 15.4 5.4 1.9 6.9 5.8 6.6 3.0 17.7 3.9 11.0 16.3 4.0 10.5 11.2 2.2 22.0 14.5 15.2 2.8 18.7 25.2 2.9 2.7 9.7 12.7 6.5 19.8 49.5 15.0 5.8 8.2 6.6 2.6 0.0 19.2 13.1 1.2 16.5 23.9 7.5 10.8 8.2 17.5 0.0 5.0 24.4 29.7 21.8 1.6 15.1 19.7 0.4 3.6 4.8 8.1 7.3 35.5 8.1 11.5 18.1 71.0 28.8 73.8 33.8 25.3 0.0 0.7 0.2 34.3 4.2 0.0 12.6 2.1 61.2 10.3 0.0 0.0 0.3 23.5 63.2 2.4 0.0 12.4 13.0 12.5 19.0 9.4 2.7 4.3 3.1 0.1 40.7 0.0 3.3 0.1 0.0 51.6 30.6 51.9 0.8 5.6 4.2 0.5 2.6 0.7 0.6 1.7 1.0 6.9 0.7 0.9 0.7 0.6 2.1 1.0 1.6 2.1 1.7 1.4 2.7 1.4 2.8 1.9 1.3 5.4 1.9 3.9 2.8 2.7 5.8 78.3 150.6 76.2 1.6 15.2 75.3 47.6 67.9 104.2 37.0 23.4 30.0 14.7 34.3 84.9 7.3 8.4 3.3 13.6 23.9 0.0 19.3 6.2 39.1 8.4 78.1 5.4 8.6 18.0 15.7 1.8 57.0 56.1 78.8 133.1 0.6 52.1 48.3 24.4 43.7 39.2 12.9 30.5 88.4 262.6 3.2 3.7 107.1 71.2 8.4 70.1 0.9 5.2 1.5 40.6 33.3 19.8 2.6 16.7 48.6 9.9 6.8 51.3 6.1 6.6 14.8 37.8 2.8 2.2 38.3 89.2 21.5 54.7 3.3 19.3 116.1 AIFM1 "AIF, AUNX1, CMTX4, DFNX5, NAMSD, PDCD8" ENSG00000156709 "Apoptosis inducing factor mitochondria associated 1" O95831 X 130124666-130165879 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" Apoptosis "DNA-binding, Oxidoreductase" "Charcot-Marie-Tooth disease, Deafness, Disease variant, Dwarfism, Mental retardation, Neurodegeneration, Neuropathy, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 165.4;Proximal tubular cells: 326.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003764, HPA030611" Enhanced Supported Mitochondria NA NA 230000 "Cluster 27: Non-specific - Gene expression" "Cluster 18: Non-specific - Mitochondria" "Cluster 25: RPMI-8226 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "CAB003764: AB_289587, HPA030611: AB_2673549" "unprognostic (3.00e-3)" "unprognostic (1.34e-2)" "unprognostic (1.34e-1)" "unprognostic (1.22e-1)" "unprognostic (2.10e-2)" "unprognostic (3.15e-3)" "unprognostic (1.46e-1)" "unprognostic (1.14e-2)" "unprognostic (1.43e-1)" "unprognostic (3.11e-2)" "unprognostic (2.54e-3)" "unprognostic (2.81e-3)" "prognostic favorable (4.42e-10)" "unprognostic (1.76e-2)" "unprognostic (1.14e-1)" "unprognostic (5.04e-2)" "unprognostic (2.11e-2)" 21.0 65.2 10.5 17.6 11.2 11.8 17.8 11.9 12.8 15.7 24.7 34.3 52.9 15.3 8.9 20.8 22.1 10.1 107.7 10.9 11.6 97.3 110.6 13.9 16.2 11.3 11.0 11.9 27.8 29.7 16.2 10.3 11.4 14.8 15.9 8.5 18.6 7.6 68.9 15.2 29.9 10.1 11.2 20.3 41.2 30.3 12.1 18.5 14.7 25.2 11.0 18.4 13.4 11.6 52.8 95.4 22.6 85.2 24.1 14.6 50.0 28.6 19.0 33.5 25.2 55.8 36.4 105.0 113.3 17.5 39.3 47.2 61.3 33.3 12.7 48.2 73.4 61.6 59.1 68.9 34.0 51.5 63.5 26.1 21.7 34.5 22.0 12.1 27.2 83.4 62.6 50.7 13.1 96.7 57.6 74.5 24.4 53.6 65.1 55.6 31.7 132.7 60.8 36.6 46.0 28.2 35.5 68.0 67.5 13.2 46.0 40.8 31.7 20.5 20.4 63.9 58.7 24.2 45.0 47.5 25.3 86.4 33.4 4.1 21.0 14.1 11.8 26.6 13.1 14.6 12.8 14.6 31.7 10.3 12.7 12.6 2.4 20.7 24.8 14.7 17.9 12.4 10.5 11.2 11.9 12.8 10.9 11.6 11.3 11.0 11.4 11.2 12.1 11.6 12.6 16.0 20.1 17.0 17.1 8.7 8.2 25.0 9.1 19.3 13.0 8.3 165.4 22.8 21.2 40.5 22.9 58.0 14.2 31.6 92.0 24.9 1.8 36.7 17.3 11.5 9.6 26.3 10.8 20.5 29.0 16.4 27.0 50.4 10.8 33.1 14.3 92.3 38.0 15.2 12.1 24.0 34.6 14.4 7.4 4.9 17.4 16.8 10.6 8.4 16.6 17.2 20.6 8.0 19.6 18.0 18.9 17.3 19.2 7.9 45.6 326.1 21.3 48.1 6.6 11.3 39.3 10.2 32.0 17.1 6.8 39.7 15.8 45.9 37.2 9.8 AIPL1 LCA4 ENSG00000129221 "Aryl hydrocarbon receptor interacting protein like 1" Q9NZN9 17 6393693-6435199 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Sensory transduction, Vision" "Disease variant, Leber congenital amaurosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 1012 "retina: 836.0" "Cell type enriched" "Detected in some" 4 "Rod photoreceptor cells: 1926.4" "Cancer enriched" "Detected in single" 12 "testis cancer: 0.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HaCaT: 1.5;OE19: 2.8" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA026578 Enhanced Uncertain Nucleoplasm,Cytosol NA NA "Cluster 79: Retina - Phototransduction" "Cluster 21: OE19 - Mitochondria" "Cluster 46: Photoreceptor cells - Phototransduction" "Nucleoplasm, Cytosol" "HPA026578: AB_2671905" "unprognostic (2.42e-2)" "unprognostic (1.17e-1)" "unprognostic (2.02e-2)" "unprognostic (1.68e-3)" "unprognostic (3.24e-1)" "unprognostic (1.13e-3)" "unprognostic (3.76e-1)" "unprognostic (5.35e-2)" 0.0 0.0 0.2 0.1 0.3 0.7 0.0 0.2 0.3 0.0 0.5 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.0 0.1 0.8 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 836.0 0.4 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.6 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.6 0.0 0.4 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.1 0.0 0.3 2.8 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.2 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.2 0.3 0.2 0.3 0.1 0.8 0.2 0.1 0.3 0.0 0.3 0.6 0.0 3.2 1.1 0.0 0.0 0.8 1.0 0.0 0.0 139.2 0.1 0.0 0.6 0.0 1.4 0.0 412.8 0.1 0.1 0.2 0.0 0.0 7.8 0.4 0.2 8.5 0.0 0.0 0.3 0.0 0.1 0.3 0.0 0.4 0.0 0.1 1.4 0.0 0.1 65.6 0.2 0.2 0.0 0.3 1.1 1.3 0.0 0.3 1.8 0.0 0.0 256.1 0.0 0.5 0.1 0.1 0.0 0.4 0.0 0.7 0.0 0.0 0.0 1926.4 0.0 1.8 0.3 0.4 0.2 0.0 0.4 0.3 0.4 0.1 0.0 1.7 ALDH18A1 "GSAS, P5CS, PYCS, SPG9" ENSG00000059573 "Aldehyde dehydrogenase 18 family member A1" P54886 10 95605941-95656711 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Amino-acid biosynthesis, Proline biosynthesis" "Kinase, Multifunctional enzyme, Oxidoreductase, Transferase" "Disease variant, Hereditary spastic paraplegia, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "salivary gland: 120.1" "Cell type enhanced" "Detected in many" "Distal enterocytes: 80.5;Granulosa cells: 81.6;Proximal enterocytes: 79.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008333, HPA012604" Approved Enhanced Mitochondria NA NA 48000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 40: Granulosa cells - Unknown function" Mitochondria "HPA008333: AB_1078125, HPA012604: AB_1844721" "unprognostic (5.97e-3)" "unprognostic (2.08e-2)" "unprognostic (5.75e-2)" "prognostic favorable (4.20e-4)" "unprognostic (1.60e-2)" "unprognostic (1.06e-1)" "unprognostic (8.30e-3)" "unprognostic (7.08e-2)" "unprognostic (4.06e-2)" "unprognostic (8.04e-2)" "unprognostic (1.30e-1)" "unprognostic (1.81e-1)" "prognostic unfavorable (3.60e-9)" "unprognostic (1.02e-3)" "unprognostic (6.57e-2)" "unprognostic (1.29e-3)" "unprognostic (6.43e-2)" 15.3 16.1 12.2 21.2 12.6 16.7 20.2 12.4 13.1 33.4 21.0 51.9 89.3 18.5 30.9 21.0 21.9 25.2 11.5 12.2 13.6 17.7 24.3 10.8 22.0 12.4 14.7 16.7 61.8 33.5 28.2 26.3 13.1 24.2 49.3 11.4 120.1 24.9 4.3 22.4 73.1 26.3 12.7 12.1 40.5 11.7 14.0 17.2 37.5 5.5 26.9 25.2 14.3 13.1 66.5 61.6 57.9 152.7 76.0 72.9 62.2 75.6 112.8 75.1 93.7 124.4 51.6 223.7 68.9 119.7 36.2 85.6 117.1 77.8 84.6 64.0 92.0 71.2 40.5 177.9 49.7 125.6 76.1 77.0 46.8 61.5 119.1 124.5 79.9 82.6 67.5 46.0 57.1 95.0 114.5 80.5 68.6 109.2 60.7 105.9 66.3 76.9 88.3 49.7 57.5 56.9 60.1 47.1 56.9 66.0 70.5 57.9 66.7 31.1 49.0 80.9 88.2 52.4 41.7 135.8 60.4 142.8 40.7 0.1 2.6 0.2 27.3 5.2 28.7 23.0 24.5 28.3 9.6 16.1 20.7 23.1 0.5 26.3 8.3 5.9 25.8 15.5 12.2 12.6 12.4 13.1 12.2 13.6 12.4 14.7 13.1 12.7 14.0 13.1 4.6 6.4 9.2 7.2 12.6 11.2 8.3 8.9 14.2 6.3 15.6 12.4 4.6 11.5 14.3 20.2 0.0 43.9 6.7 80.5 1.9 13.7 1.3 12.7 18.1 8.0 19.8 17.9 15.7 21.1 31.6 16.2 18.8 16.9 8.2 81.6 5.3 27.3 11.5 10.1 13.6 41.3 8.2 3.5 3.8 1.6 9.3 3.5 16.0 11.2 2.6 7.1 8.2 17.6 12.8 11.7 56.4 12.0 30.1 18.4 79.4 8.4 15.2 3.4 0.0 10.5 10.1 8.2 9.9 17.6 8.1 30.2 9.0 10.8 38.7 9.4 ALDH7A1 "ATQ1, EPD, PDE" ENSG00000164904 "Aldehyde dehydrogenase 7 family member A1" P49419 5 126531200-126595362 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 162.2" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 414.1;Proximal tubular cells: 302.1;Syncytiotrophoblasts: 222.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "plasmacytoid DC: 6.4" "Lineage enriched" "Detected in many" 5 "dendritic cells: 6.4" "Cell line enhanced" "Detected in many" "HBEC3-KT: 256.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023296, HPA053675" Enhanced Supported Mitochondria,Cytosol Yes No 430000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 15: Liver - Metabolism" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Mitochondria Cytosol "HPA023296: AB_1844738, HPA053675: " "unprognostic (1.37e-1)" "unprognostic (9.67e-2)" "unprognostic (2.07e-2)" "unprognostic (2.20e-2)" "unprognostic (4.15e-2)" "unprognostic (1.32e-1)" "unprognostic (1.58e-3)" "unprognostic (9.49e-3)" "unprognostic (7.61e-2)" "unprognostic (7.08e-2)" "unprognostic (2.10e-1)" "unprognostic (1.33e-1)" "prognostic favorable (3.08e-4)" "unprognostic (1.51e-1)" "unprognostic (3.70e-1)" "unprognostic (3.10e-3)" "unprognostic (4.93e-2)" 23.7 38.3 46.6 9.1 47.6 1.8 47.1 43.7 45.8 32.7 40.7 29.5 23.7 25.1 8.8 35.9 28.8 19.1 27.9 44.7 43.2 115.1 162.2 15.7 8.6 43.1 43.5 65.3 27.0 34.0 8.8 44.9 42.6 42.0 27.4 19.7 40.6 27.9 12.2 29.4 21.0 23.6 44.8 7.0 23.6 12.3 44.0 18.3 47.6 26.5 17.1 18.1 20.9 45.2 64.9 41.9 116.6 193.4 95.5 56.4 147.8 76.1 93.4 86.5 110.5 118.6 60.7 0.0 75.5 60.0 36.1 47.1 36.5 256.2 78.8 0.1 44.6 12.3 63.1 102.1 46.3 0.2 0.0 69.0 59.2 67.3 47.7 64.2 70.0 0.0 0.0 0.1 77.1 42.1 2.6 0.3 79.4 47.5 35.2 38.9 131.8 0.0 81.2 48.4 39.4 47.2 0.0 41.1 44.7 89.0 75.2 2.7 86.1 24.8 75.6 28.8 53.1 0.1 0.1 0.4 13.4 0.2 40.6 0.7 0.2 0.1 0.1 0.0 0.2 0.8 0.2 0.1 1.8 0.6 1.2 0.6 0.1 0.1 0.0 6.4 0.0 0.4 46.6 47.6 43.7 45.8 44.7 43.2 43.1 43.5 42.6 44.8 44.0 45.2 17.6 16.0 29.3 99.3 5.0 25.9 59.5 110.0 87.0 23.6 40.6 91.1 39.9 27.1 43.5 42.3 22.9 414.1 3.7 15.2 76.3 43.5 31.4 18.7 44.3 19.1 21.7 5.2 16.0 13.8 107.8 34.0 27.0 21.4 7.0 50.4 18.9 74.6 51.1 25.2 21.5 25.9 20.3 9.4 7.6 41.7 25.4 9.1 55.2 12.2 7.5 102.1 0.0 41.7 30.0 12.6 15.6 37.2 2.0 27.5 23.4 302.1 23.4 13.6 19.7 19.4 25.8 1.0 5.1 59.2 16.1 222.3 4.6 39.3 46.4 50.4 ALG13 "CDG1S, CXorf45, FLJ23018, GLT28D1, MDS031, TDRD13, YGL047W" ENSG00000101901 "ALG13 UDP-N-acetylglucosaminyltransferase subunit" Q9NP73 X 111665811-111760649 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Glycosyltransferase, Hydrolase, Multifunctional enzyme, Protease, Thiol protease, Transferase" "Congenital disorder of glycosylation, Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002853, HPA005498" Approved Approved Vesicles,Cytosol NA NA 11000000 "Cluster 34: Basophils - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 2: Karpas-707 - Immune response" "Cluster 24: Non-specific - Transcription regulation" Vesicles Cytosol "HPA002853: AB_1078131, HPA005498: " "unprognostic (4.13e-1)" "unprognostic (1.80e-1)" "unprognostic (2.45e-2)" "unprognostic (1.51e-1)" "unprognostic (6.97e-2)" "unprognostic (6.14e-2)" "unprognostic (2.74e-1)" "unprognostic (6.55e-3)" "unprognostic (2.26e-2)" "unprognostic (3.39e-3)" "unprognostic (1.73e-2)" "unprognostic (4.62e-3)" "prognostic unfavorable (1.10e-6)" "unprognostic (1.19e-1)" "unprognostic (1.29e-2)" "unprognostic (9.70e-2)" "unprognostic (2.45e-2)" 15.1 17.9 10.5 18.8 11.7 16.6 18.3 11.5 19.0 17.2 12.3 18.2 13.7 16.1 20.5 14.7 15.4 16.4 13.2 10.2 13.8 21.0 23.8 13.8 23.4 12.6 12.1 15.8 14.7 23.4 17.9 14.1 13.3 17.7 19.4 11.8 15.6 13.4 9.2 19.4 17.3 17.5 11.4 18.5 15.5 17.4 11.8 17.3 18.2 9.9 20.1 21.3 14.7 16.6 22.3 24.4 21.8 13.8 13.8 19.6 12.3 17.7 18.3 22.4 27.5 24.9 23.1 19.5 33.0 24.7 46.5 12.6 26.1 12.5 23.5 14.4 17.6 10.7 26.1 28.4 20.3 19.5 40.5 23.6 22.8 18.0 38.6 23.3 24.8 21.8 23.9 53.5 22.5 55.8 16.4 17.6 19.9 66.3 33.6 12.8 13.9 26.7 36.6 34.0 13.1 19.1 25.2 15.2 16.3 21.7 13.6 18.5 16.7 19.2 9.7 24.9 34.4 25.8 47.1 31.5 20.5 25.5 15.2 39.5 15.8 16.6 9.5 16.3 9.3 10.6 10.6 9.2 18.5 12.1 13.0 10.8 3.0 4.6 12.9 9.5 14.6 9.6 10.5 11.7 11.5 19.0 10.2 13.8 12.6 12.1 13.3 11.4 11.8 16.6 50.9 16.0 30.8 33.6 127.9 35.2 65.8 53.5 33.6 15.1 33.9 31.6 18.7 22.8 36.0 18.4 10.4 27.3 73.9 39.2 45.0 37.4 21.1 48.2 31.1 37.4 26.5 27.1 64.7 52.1 39.1 34.6 37.2 47.9 109.8 15.7 28.2 28.4 42.5 11.8 57.4 49.0 46.8 39.2 52.3 9.4 21.5 56.1 28.4 83.4 41.8 16.0 29.9 41.7 77.5 58.0 55.6 16.1 60.4 46.9 38.5 55.5 35.3 16.5 26.3 38.7 46.2 32.6 22.4 26.5 35.4 48.7 71.1 28.8 32.8 64.6 ALG14 MGC19780 ENSG00000172339 "ALG14 UDP-N-acetylglucosaminyltransferase subunit" Q96F25 1 94974405-95072951 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031829 Approved Approved Nucleoplasm,Nucleoli NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 68: Epididymis - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 55: Plasma cells - Humoral immune response" Nucleoli Nucleoplasm "HPA031829: AB_2674062" "unprognostic (7.79e-2)" "unprognostic (3.59e-2)" "unprognostic (1.51e-3)" "unprognostic (1.75e-3)" "unprognostic (1.36e-1)" "unprognostic (6.56e-2)" "unprognostic (4.00e-1)" "unprognostic (2.17e-2)" "unprognostic (3.18e-1)" "unprognostic (2.01e-1)" "unprognostic (7.79e-2)" "unprognostic (1.15e-1)" "unprognostic (1.24e-1)" "unprognostic (9.55e-2)" "unprognostic (6.01e-2)" "unprognostic (4.99e-2)" "unprognostic (1.93e-1)" 1.2 2.5 1.5 0.8 1.7 0.9 1.3 2.2 1.9 1.0 1.7 1.6 1.8 0.8 2.3 1.0 0.8 1.2 0.9 1.6 1.4 1.5 2.1 0.7 0.8 1.7 1.4 0.9 1.8 1.6 1.0 0.8 1.5 0.9 1.7 1.4 1.8 0.8 1.5 0.9 1.3 0.8 1.2 0.8 1.1 1.1 1.7 0.7 1.7 0.5 0.8 0.9 0.7 2.2 2.5 1.6 1.3 1.2 1.0 1.7 1.1 1.8 1.9 1.8 1.5 1.8 0.8 1.3 1.8 2.2 2.2 1.7 1.5 1.7 2.2 2.8 2.5 0.7 1.6 2.9 1.6 1.7 0.4 1.9 1.7 1.4 1.3 1.4 1.6 1.7 1.4 1.6 1.8 1.2 1.9 1.1 0.8 2.5 2.2 1.2 2.6 1.4 2.1 1.4 1.1 1.5 1.0 3.4 3.2 0.9 1.5 1.5 1.2 1.1 1.3 2.0 3.9 1.0 1.0 1.1 0.8 0.8 0.9 1.3 1.0 0.3 0.8 1.3 0.7 1.6 0.9 1.0 1.5 1.4 0.8 0.9 0.8 0.9 0.6 1.9 1.3 0.6 1.5 1.7 2.2 1.9 1.6 1.4 1.7 1.4 1.5 1.2 1.7 2.2 11.8 0.0 12.2 14.0 13.1 11.7 11.4 30.5 19.4 16.9 13.8 15.2 7.7 10.0 20.3 16.5 6.2 34.6 10.5 25.7 19.6 24.9 10.0 12.2 19.6 10.1 4.2 13.0 24.6 53.7 25.9 18.9 11.2 13.3 1.3 14.7 11.7 32.4 18.9 8.4 22.4 12.9 18.3 8.4 8.9 8.4 14.3 8.6 32.0 14.0 10.3 30.9 3.1 14.6 35.4 23.6 22.6 10.1 41.6 8.9 22.1 40.0 12.7 14.4 32.9 17.1 15.2 36.1 23.0 19.0 8.7 25.2 5.6 39.9 26.9 12.9 ALG2 "CDG1I, CDGIi, FLJ14511, hALPG2, NET38" ENSG00000119523 "ALG2 alpha-1,3/1,6-mannosyltransferase" Q9H553 9 99216425-99221942 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation, Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041512, HPA041601" Approved Approved "Golgi apparatus" NA No "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 29: Non-specific - Vesicular transport" "Cluster 30: Epithelial cell lines - Translation" "Cluster 55: Plasma cells - Humoral immune response" "Golgi apparatus" "HPA041512: AB_10794380, HPA041601: AB_10794302" "unprognostic (8.86e-3)" "unprognostic (4.39e-1)" "unprognostic (2.37e-1)" "prognostic favorable (8.44e-5)" "unprognostic (9.21e-3)" "prognostic unfavorable (1.56e-4)" "unprognostic (1.06e-2)" "unprognostic (5.94e-2)" "unprognostic (3.31e-1)" "unprognostic (3.66e-1)" "unprognostic (2.99e-2)" "unprognostic (1.08e-1)" "prognostic favorable (2.28e-7)" "unprognostic (4.16e-2)" "unprognostic (1.73e-1)" "unprognostic (3.10e-2)" "unprognostic (4.81e-1)" 17.7 38.2 13.4 19.4 14.6 23.0 27.1 16.6 18.4 35.1 19.8 24.9 21.9 23.8 74.0 15.1 29.5 26.2 13.4 14.5 15.0 34.3 47.4 24.3 20.8 14.7 16.1 30.2 42.0 37.0 21.8 29.9 15.1 32.8 27.3 15.0 37.9 34.5 15.3 17.9 20.5 24.2 14.8 17.9 25.0 19.2 14.7 16.7 42.3 13.5 27.5 31.7 10.9 16.9 22.9 28.7 22.7 34.4 82.6 52.7 42.0 46.7 75.3 45.6 39.3 34.9 31.2 24.6 18.8 54.3 60.0 85.3 37.9 49.1 45.7 35.2 16.2 14.4 23.7 54.0 99.7 28.2 26.2 61.9 65.2 37.7 72.8 45.8 52.3 15.1 23.2 56.2 44.7 47.8 12.9 29.8 27.6 75.0 39.6 14.0 43.4 38.1 65.2 31.1 22.5 19.3 33.5 63.8 61.6 33.5 24.4 23.3 38.8 31.4 27.9 40.9 28.6 45.8 28.0 10.5 58.6 20.5 16.3 38.7 35.5 22.0 33.7 28.2 49.2 30.8 32.0 33.9 45.1 26.3 27.7 27.4 9.3 38.0 28.4 79.9 38.3 36.0 13.4 14.6 16.6 18.4 14.5 15.0 14.7 16.1 15.1 14.8 14.7 16.9 12.6 12.8 22.9 6.8 22.1 23.3 26.8 56.2 10.2 11.3 22.6 16.6 6.9 32.9 35.8 23.9 2.1 50.3 30.2 20.0 21.5 36.1 28.7 16.9 30.9 19.8 12.5 12.0 8.1 35.2 34.2 30.4 15.3 26.4 7.6 14.1 21.8 55.5 28.1 10.1 8.3 26.3 38.7 25.8 45.4 20.3 26.8 23.0 21.4 10.3 64.2 15.5 15.5 9.5 9.7 31.9 16.0 25.2 47.0 37.3 18.7 36.6 33.1 8.3 6.6 17.2 18.2 22.6 24.6 15.0 23.7 89.2 16.6 25.6 20.8 31.3 ALS2 ALS2CR6 ENSG00000003393 "Alsin Rho guanine nucleotide exchange factor ALS2" Q96Q42 2 201700267-201782112 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Guanine-nucleotide releasing factor" "Amyotrophic lateral sclerosis, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 91.8;granulocytes: 46.9;Inhibitory neurons: 66.6" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in many" 6 "cerebellum: 26.4" "Group enriched" "Detected in many" 5 "basophil: 23.0;eosinophil: 6.8" "Lineage enriched" "Detected in all" 8 "granulocytes: 23.0" "Cell line enhanced" "Detected in all" "HMC-1: 50.4" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebellum: 87.8" HPA046588 Enhanced Approved "Intermediate filaments,Cytosol" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 3: HMC-1 - Innate immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Intermediate filaments, Cytosol" "HPA046588: AB_2679709" "unprognostic (3.43e-2)" "unprognostic (2.11e-1)" "unprognostic (1.33e-1)" "unprognostic (2.07e-3)" "unprognostic (2.72e-1)" "unprognostic (7.47e-2)" "unprognostic (1.04e-3)" "unprognostic (9.17e-2)" "unprognostic (4.16e-2)" "unprognostic (1.52e-1)" "unprognostic (2.99e-1)" "unprognostic (2.83e-2)" "unprognostic (1.09e-2)" "unprognostic (1.88e-1)" "unprognostic (1.61e-1)" "unprognostic (2.10e-1)" "unprognostic (1.84e-1)" 7.3 5.5 2.6 2.6 3.1 5.6 6.8 26.4 4.2 6.4 4.5 6.6 3.2 6.6 7.8 4.8 6.4 3.8 13.7 3.4 1.6 8.0 14.5 6.7 2.8 0.9 1.0 6.0 5.7 4.3 10.0 3.5 1.7 6.1 3.4 5.4 5.4 1.6 13.5 7.1 6.6 4.8 0.3 5.3 6.8 5.3 1.4 2.4 6.3 5.9 2.8 6.2 5.7 2.6 6.5 6.7 7.1 5.6 7.0 5.1 7.2 8.6 10.4 14.0 13.2 5.8 8.4 1.2 3.8 11.7 6.1 3.7 4.6 10.6 18.0 3.5 4.8 15.3 6.2 5.2 8.1 16.4 50.4 9.8 4.1 11.5 14.0 5.7 10.0 8.6 9.8 5.7 9.6 7.5 6.7 20.3 9.2 4.6 5.3 5.4 7.7 4.2 9.8 8.8 3.4 7.8 6.4 7.1 9.2 14.3 5.4 7.2 7.9 11.6 7.2 3.5 6.2 7.1 9.2 4.5 8.5 3.4 7.2 23.0 0.9 6.8 1.6 1.7 1.9 1.2 1.3 1.3 1.4 1.0 1.5 1.5 0.9 3.0 1.2 0.8 2.1 0.8 2.6 3.1 26.4 4.2 3.4 1.6 0.9 1.0 1.7 0.3 1.4 2.6 7.6 12.8 16.7 28.7 2.8 5.4 3.8 4.4 3.4 15.1 5.4 4.3 32.3 8.6 4.3 9.2 29.2 5.7 3.7 3.6 0.0 6.9 16.5 14.0 6.8 10.4 4.8 12.0 91.8 3.3 3.2 6.9 9.7 6.8 46.9 10.1 13.2 20.3 5.9 8.4 66.6 6.9 2.0 3.2 3.0 6.5 7.8 4.8 0.0 27.2 3.1 5.9 4.1 36.2 44.0 6.1 3.9 8.2 2.3 4.4 7.8 6.1 17.5 15.4 0.0 9.3 8.4 7.3 5.6 4.6 6.0 6.7 3.9 5.2 4.7 3.7 AMPD2 SPG63 ENSG00000116337 "Adenosine monophosphate deaminase 2" Q01433 1 109616104-109632051 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Nucleotide metabolism" Hydrolase "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 62.6;Horizontal cells: 52.2;Macrophages: 52.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "classical monocyte: 19.4;eosinophil: 19.2;intermediate monocyte: 40.7;myeloid DC: 18.9;neutrophil: 61.1;non-classical monocyte: 44.6" "Group enriched" "Detected in all" 5 "dendritic cells: 18.9;granulocytes: 61.1;monocytes: 44.6" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027137, HPA045760" Approved Enhanced Cytosol NA NA 230000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 41: Macrophages - Immune response" Cytosol "HPA027137: AB_2672129, HPA045760: AB_2679443" "unprognostic (2.78e-2)" "unprognostic (1.21e-1)" "unprognostic (1.50e-1)" "unprognostic (1.43e-3)" "unprognostic (9.01e-2)" "unprognostic (5.25e-2)" "unprognostic (3.91e-3)" "unprognostic (1.71e-1)" "unprognostic (4.02e-1)" "unprognostic (1.23e-1)" "unprognostic (8.10e-3)" "unprognostic (1.50e-1)" "prognostic unfavorable (3.78e-10)" "unprognostic (9.16e-2)" "unprognostic (2.03e-1)" "unprognostic (1.35e-2)" "unprognostic (1.60e-1)" 9.3 17.5 31.2 12.0 41.6 28.6 7.4 22.9 34.7 13.1 36.6 7.5 10.7 11.5 4.1 7.2 13.1 8.8 7.2 34.8 37.0 10.5 16.2 13.4 7.6 34.7 31.7 17.5 10.0 9.4 45.8 7.6 33.6 10.8 4.1 10.5 9.2 12.0 3.3 8.5 10.8 7.1 27.9 19.0 8.6 4.3 39.3 4.9 10.6 1.5 5.9 7.5 11.4 29.0 20.6 22.5 20.5 20.1 18.0 18.7 8.6 25.6 57.2 24.9 25.0 19.1 7.0 10.5 21.8 39.1 16.0 11.3 15.8 20.0 13.4 13.0 20.7 46.0 15.6 19.3 24.9 15.7 45.7 23.3 13.2 32.5 24.1 28.2 26.7 17.0 17.4 13.0 16.0 23.2 26.7 29.0 20.6 17.1 22.9 18.6 15.8 17.3 24.2 8.7 19.3 22.4 17.4 19.8 24.6 5.7 10.4 16.2 16.7 27.7 39.0 33.7 25.4 48.4 28.4 12.1 50.8 25.9 35.1 0.5 19.4 19.2 5.3 40.7 8.0 5.3 5.2 4.9 18.9 2.7 6.4 5.1 61.1 4.3 44.6 2.6 4.0 12.3 31.2 41.6 22.9 34.7 34.8 37.0 34.7 31.7 33.6 27.9 39.3 29.0 3.6 3.2 5.5 13.7 9.4 8.9 5.4 5.0 9.1 41.0 8.8 11.4 3.2 12.8 5.4 0.0 62.6 4.9 10.0 4.2 7.9 9.8 3.5 4.4 9.4 7.1 17.5 5.0 13.3 11.2 8.6 12.6 14.3 5.5 3.8 11.0 6.1 20.5 10.8 52.2 17.6 9.6 2.0 42.1 42.0 1.3 13.1 52.5 5.4 6.5 16.1 10.5 6.2 12.1 10.6 10.3 3.0 21.4 11.1 11.1 6.1 4.5 4.2 7.2 13.1 8.8 10.6 4.2 3.8 7.9 8.1 2.6 15.4 8.5 10.7 4.0 ANG "RAA1, RNASE5" ENSG00000214274 Angiogenin P03950 14 20684177-20698971 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Angiogenesis, Differentiation, Stress response" "Developmental protein, DNA-binding, Endonuclease, Hydrolase, Nuclease, Protein synthesis inhibitor" "Amyotrophic lateral sclerosis, Cancer-related genes, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 52 "liver: 3018.1" "Cell type enriched" "Detected in many" 24 "Hepatocytes: 4816.3" "Cancer enriched" "Detected in all" 17 "liver cancer: 279.2" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "classical monocyte: 24.5;myeloid DC: 14.5" "Low lineage specificity" "Detected in many" "Group enriched" "Detected in many" 5 "Hep G2: 152.2;OE19: 116.1" "Low region specificity" "Detected in all" HPA055896 Approved "Nucleoli,Nucleoli rim,Mitotic chromosome,Actin filaments" "Secreted to blood" Yes No 308000000 410000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 62: Liver - Hemostasis" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" "Nucleoli, Nucleoli rim, Mitotic chromosome" "Actin filaments" "HPA055896: " "unprognostic (2.50e-2)" "unprognostic (1.82e-1)" "unprognostic (9.77e-2)" "prognostic favorable (6.85e-4)" "unprognostic (5.71e-3)" "unprognostic (6.99e-2)" "prognostic favorable (7.83e-5)" "unprognostic (1.16e-1)" "unprognostic (3.20e-3)" "unprognostic (9.19e-3)" "unprognostic (1.31e-1)" "unprognostic (3.69e-1)" "unprognostic (6.65e-2)" "unprognostic (1.03e-1)" "unprognostic (3.39e-1)" "unprognostic (2.00e-1)" "unprognostic (3.09e-1)" 37.6 3.0 3.6 6.0 3.5 1.0 37.8 3.5 4.9 38.2 5.6 32.6 23.2 23.4 17.9 9.8 30.5 28.5 16.9 3.6 4.9 18.4 3018.1 18.5 3.5 4.5 4.2 58.1 30.8 5.3 5.0 3.8 4.3 32.7 45.7 2.2 52.6 13.3 6.2 27.4 27.1 10.4 4.5 7.4 58.2 10.2 3.7 1.5 8.8 10.5 4.1 24.8 31.4 4.8 3.7 9.9 2.3 0.0 23.9 27.8 0.3 4.8 8.8 1.1 4.0 5.9 5.1 0.4 1.5 12.0 8.0 3.8 2.8 3.1 1.3 18.4 3.8 0.9 5.1 152.2 5.0 4.0 0.5 22.2 2.5 1.5 5.1 11.8 5.7 4.2 0.2 27.0 3.5 0.7 0.9 1.2 0.7 116.1 10.7 0.7 3.9 11.3 2.3 2.9 0.0 0.4 4.6 1.7 6.5 5.1 4.0 0.7 6.0 1.9 2.8 1.7 0.7 5.9 4.8 0.5 3.2 2.0 5.0 0.0 24.5 0.0 0.6 2.9 0.4 5.8 1.2 1.1 14.5 4.9 0.3 0.2 0.4 0.0 0.1 2.3 0.8 7.1 3.6 3.5 3.5 4.9 3.6 4.9 4.5 4.2 4.3 4.5 3.7 4.8 9.7 28.9 17.7 0.0 9.7 27.1 43.3 39.2 14.2 0.1 33.8 24.8 0.8 194.5 24.6 11.0 0.0 1.6 0.7 32.5 11.7 40.0 1.0 6.2 9.7 11.0 71.0 27.8 0.0 31.6 5.3 48.8 56.1 24.9 0.0 10.7 62.4 4816.3 15.9 0.0 0.0 171.9 12.2 95.9 18.7 2.9 71.1 13.8 23.2 0.0 4.9 10.1 0.0 0.0 0.0 21.6 33.3 24.0 11.7 43.7 91.3 61.2 76.5 0.6 13.1 29.7 17.7 1.0 1.3 9.4 52.4 9.3 5.6 0.5 51.6 39.2 ANO10 "FLJ10375, MGC47890, SCAR10, TMEM16K" ENSG00000160746 "Anoctamin 10" Q9NW15 3 43354859-43691594 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal tubular cells: 123.3;Excitatory neurons: 77.4;Inhibitory neurons: 97.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016624, HPA051569" Approved Supported "Vesicles,Plasma membrane" NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 37: Intestine - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane" Vesicles "HPA016624: , HPA051569: AB_2681537" "unprognostic (1.51e-3)" "unprognostic (1.38e-2)" "prognostic favorable (6.70e-4)" "prognostic favorable (1.11e-4)" "unprognostic (4.23e-1)" "unprognostic (2.69e-2)" "prognostic unfavorable (3.19e-4)" "unprognostic (7.99e-3)" "unprognostic (1.03e-2)" "unprognostic (1.56e-1)" "unprognostic (1.05e-1)" "unprognostic (1.33e-1)" "prognostic favorable (6.41e-6)" "unprognostic (9.83e-3)" "unprognostic (1.22e-1)" "unprognostic (5.19e-3)" "unprognostic (5.71e-2)" 26.6 14.1 17.6 15.1 18.6 33.0 21.8 23.9 20.9 22.3 18.4 39.4 61.1 21.6 13.6 25.3 13.9 19.4 12.7 18.1 21.1 29.9 14.1 16.9 7.6 22.7 22.9 13.9 15.2 23.7 13.9 18.1 23.2 14.2 33.7 10.1 28.6 20.2 15.5 32.0 54.7 28.0 19.6 9.1 13.5 13.0 19.8 7.1 24.5 11.6 9.7 18.1 21.5 24.1 30.6 23.6 26.1 27.4 101.1 53.5 31.2 87.7 141.1 42.0 54.4 16.2 27.5 3.1 27.4 114.8 43.1 16.3 20.6 47.0 52.6 33.6 14.2 39.4 28.7 17.7 43.9 7.2 31.1 50.5 36.3 53.6 71.8 79.4 100.3 18.7 30.8 24.9 95.2 20.8 7.8 5.2 31.3 23.7 28.6 6.3 18.7 10.2 85.5 31.4 6.4 19.4 34.4 27.0 19.8 45.3 59.5 14.5 84.7 66.2 24.4 70.2 40.7 15.7 22.9 1.1 60.2 14.6 44.2 7.4 19.0 1.4 6.7 11.1 3.8 2.7 4.6 4.5 13.1 2.5 3.9 6.0 32.8 9.7 12.7 2.3 5.4 7.0 17.6 18.6 23.9 20.9 18.1 21.1 22.7 22.9 23.2 19.6 19.8 24.1 24.3 6.4 3.2 70.2 4.1 5.6 5.8 6.9 8.0 8.0 18.2 8.4 5.2 8.6 13.2 14.7 0.0 14.4 3.7 38.5 123.3 21.6 2.9 11.8 23.6 17.8 9.6 11.8 77.4 17.8 19.5 10.6 10.2 31.2 2.5 6.8 23.6 10.7 11.6 10.1 97.9 23.8 10.2 9.6 5.3 5.2 5.6 9.1 14.2 69.3 9.2 17.1 5.2 71.4 46.4 11.7 22.1 10.1 2.6 4.4 58.4 19.0 4.0 3.6 6.6 19.1 15.7 17.1 23.6 8.7 6.1 17.1 5.8 6.2 26.9 4.8 ANO3 "C11orf25, DYT23, GENX-3947, TMEM16C" ENSG00000134343 "Anoctamin 3" Q9BYT9 11 26188842-26663289 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Lipid transport, Transport" "Disease variant, Dystonia" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 19 "brain: 59.2;epididymis: 57.4" "Cell type enriched" "Detected in some" 5 "Excitatory neurons: 201.9" "Not detected" "Not detected" "Region enriched" "Detected in many" 5 "basal ganglia: 59.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "GAMG: 1.9;HDLM-2: 6.8;U-2 OS: 1.6;U-2197: 4.3" "Region enhanced" "Detected in all" "basal ganglia: 158.9" "Region enriched" "Detected in all" 7 "basal ganglia: 180.1" HPA041629 Uncertain NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 44: HDLM-2 - Immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA041629: AB_10793969" "unprognostic (7.01e-3)" "unprognostic (4.31e-1)" "unprognostic (2.94e-1)" "unprognostic (9.29e-2)" "unprognostic (9.28e-2)" "unprognostic (1.25e-1)" "unprognostic (1.35e-1)" "unprognostic (2.75e-2)" "unprognostic (1.66e-1)" "unprognostic (2.45e-2)" "unprognostic (7.02e-2)" "unprognostic (1.32e-1)" "unprognostic (7.81e-4)" "unprognostic (9.48e-3)" "unprognostic (3.50e-2)" "unprognostic (4.33e-1)" "unprognostic (4.01e-1)" 3.0 0.8 4.3 0.1 59.2 0.0 0.5 0.0 11.8 0.5 0.0 0.2 0.1 0.1 57.4 0.0 0.2 1.8 0.3 7.7 0.0 1.0 1.1 0.4 0.0 1.1 0.1 0.1 0.3 0.1 0.3 0.0 1.9 0.0 0.1 0.4 0.2 0.1 0.0 0.1 0.1 0.2 0.0 0.4 0.0 1.9 0.3 0.1 1.0 0.1 0.0 0.0 0.1 1.7 0.0 0.0 0.4 0.0 1.1 1.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 1.9 0.0 0.0 0.0 0.0 6.8 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.1 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 4.3 0.0 0.4 1.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.3 59.2 0.0 11.8 7.7 0.0 1.1 0.1 1.9 0.0 0.3 1.7 1.0 0.0 2.0 3.3 0.0 0.0 0.0 0.1 0.0 1.7 0.2 0.0 0.9 0.0 0.2 0.0 14.6 0.2 0.0 0.0 0.0 0.1 12.0 0.5 0.0 0.4 0.0 0.0 201.9 0.0 0.3 0.5 0.0 0.3 0.0 0.0 1.8 0.7 0.0 8.4 4.1 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 8.4 0.0 0.0 0.0 38.2 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.3 2.3 0.0 0.0 4.7 3.8 2.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 ANXA11 ANX11 ENSG00000122359 "Annexin A11" P50995 10 80150889-80205572 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Cell cycle, Cell division" "Amyotrophic lateral sclerosis, Cancer-related genes, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "eosinophil: 443.8" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004851, HPA027545" Supported Supported Nucleoplasm,Cytosol NA NA 210000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm Cytosol "CAB004851: AB_626682, HPA027545: AB_1844851" "unprognostic (1.85e-2)" "unprognostic (2.85e-2)" "unprognostic (5.35e-3)" "unprognostic (5.06e-2)" "unprognostic (8.18e-3)" "unprognostic (1.99e-1)" "unprognostic (4.01e-3)" "unprognostic (6.28e-2)" "unprognostic (2.32e-2)" "unprognostic (4.88e-2)" "unprognostic (3.46e-2)" "unprognostic (2.56e-2)" "prognostic favorable (6.69e-8)" "unprognostic (2.69e-3)" "unprognostic (1.84e-1)" "unprognostic (6.79e-2)" "unprognostic (2.02e-1)" 139.9 29.5 39.0 99.4 40.6 192.9 107.6 27.5 46.8 86.6 52.8 130.3 138.0 74.3 107.5 210.2 109.0 84.8 236.2 47.3 29.0 144.7 47.7 109.5 81.2 26.4 26.6 78.2 95.4 81.8 27.2 91.1 23.9 100.3 120.7 4.8 94.1 81.8 188.9 75.6 137.2 86.0 25.4 76.2 139.3 24.5 24.6 100.2 61.4 166.2 101.7 148.1 102.8 30.4 221.7 195.7 10.4 53.9 220.2 201.1 119.6 149.5 397.3 95.7 98.8 168.7 338.2 13.1 113.6 236.7 8.1 277.7 44.6 136.2 54.2 384.3 76.0 84.4 98.9 131.5 129.4 92.0 212.3 222.9 74.6 57.8 39.4 178.9 143.9 117.9 82.1 163.7 76.8 127.3 119.8 200.9 19.6 211.5 367.7 91.7 14.9 344.0 155.1 191.8 5.1 37.9 65.0 269.9 156.4 83.4 80.6 120.6 160.0 68.7 101.4 157.6 84.4 91.7 145.6 96.0 66.6 155.4 47.4 130.8 66.8 443.8 72.9 52.4 75.0 64.9 92.5 100.5 49.4 54.2 83.7 74.4 231.8 61.3 59.1 78.5 126.5 85.4 39.0 40.6 27.5 46.8 47.3 29.0 26.4 26.6 23.9 25.4 24.6 30.4 150.5 96.1 78.4 17.3 101.4 51.2 266.4 219.4 92.8 1.6 58.8 50.4 293.3 203.0 227.1 220.7 0.0 271.7 137.1 457.7 332.6 429.2 4.5 180.6 49.7 82.7 77.5 29.9 29.5 352.5 309.8 113.1 175.8 265.7 116.1 81.4 91.4 40.8 228.1 3.3 15.5 186.9 97.6 149.7 167.4 9.6 92.9 155.0 90.7 24.4 208.2 38.9 159.6 3.0 2.3 420.6 461.0 92.6 98.2 414.9 367.7 156.8 229.0 2.8 92.1 56.4 137.9 2.8 51.5 98.4 42.1 185.5 131.9 50.8 227.8 581.4 AP000812.4 ENSG00000284922 "Leucine rich transmembrane and O-methyltransferase domain containing" Q8WZ04 11 72080331-72110782 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Catecholamine metabolism, Hearing, Neurotransmitter degradation" "Methyltransferase, Transferase" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 7 "fallopian tube: 14.1;testis: 9.5" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "fHDF/TERT166: 2.9;HBEC3-KT: 2.9;MCF7: 3.0" HPA039949 Approved Uncertain Microtubules NA NA "Cluster 40: Non-specific - Basic cellular processes" Microtubules "HPA039949: AB_10960708" 0.1 0.0 0.4 0.0 0.5 0.0 0.2 0.6 1.8 0.0 0.1 0.0 0.0 0.9 0.0 0.0 14.1 0.0 0.0 0.3 0.6 0.4 0.2 0.6 0.0 0.4 0.4 0.2 0.0 0.5 0.0 0.4 0.0 0.1 0.1 0.0 0.2 0.4 0.0 0.2 0.2 0.3 0.2 0.0 9.5 0.4 0.0 0.1 0.0 0.0 0.1 0.6 0.2 0.1 0.0 0.2 0.7 0.2 0.1 0.4 0.5 0.3 1.2 0.2 0.2 0.0 0.1 2.9 0.5 0.6 0.4 2.9 0.3 1.2 0.5 0.5 0.2 0.2 0.0 0.0 0.0 0.8 0.0 1.3 0.4 0.1 0.1 0.6 0.0 0.0 0.4 3.0 0.0 0.0 0.1 1.0 0.0 0.6 0.5 0.2 0.9 0.5 0.3 0.1 0.4 0.3 0.0 0.0 0.9 0.1 0.0 0.2 0.2 0.4 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.5 0.6 1.8 0.3 0.6 0.4 0.4 0.4 0.3 0.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 AP3B2 NAPTB ENSG00000103723 "Adaptor related protein complex 3 subunit beta 2" Q13367 15 82659281-82710112 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Protein transport, Transport" Epilepsy "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 20.7;pituitary gland: 18.8;retina: 33.0" "Cell type enhanced" "Detected in some" "Cone photoreceptor cells: 27.1;Excitatory neurons: 61.7;Inhibitory neurons: 56.9;Oligodendrocyte precursor cells: 44.7;Oligodendrocytes: 22.8;Rod photoreceptor cells: 58.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 9.5;NTERA-2: 9.5;RT4: 17.3;SCLC-21H: 29.0;SH-SY5Y: 17.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039467, HPA039818" Enhanced Supported Approved "Nucleoplasm,Golgi apparatus,Cytosol" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 58: Brain - Synaptic function" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 46: Photoreceptor cells - Phototransduction" "Golgi apparatus" "Nucleoplasm, Cytosol" "HPA039467: AB_10795143, HPA039818: AB_10795299" "unprognostic (3.17e-1)" "unprognostic (9.40e-2)" "unprognostic (5.33e-2)" "unprognostic (1.48e-6)" "unprognostic (8.44e-2)" "unprognostic (7.62e-2)" "unprognostic (5.82e-2)" "unprognostic (2.32e-1)" "unprognostic (3.85e-1)" "unprognostic (1.63e-1)" "unprognostic (3.57e-3)" "unprognostic (1.12e-1)" "unprognostic (8.66e-2)" "unprognostic (4.95e-2)" "unprognostic (3.21e-2)" "unprognostic (7.52e-2)" "unprognostic (1.43e-2)" 0.7 4.5 15.3 0.9 18.6 1.1 1.4 15.5 20.7 0.9 0.0 1.1 0.7 1.1 2.3 0.7 0.9 0.4 0.2 19.6 5.5 0.6 0.2 0.3 0.5 15.6 5.4 1.2 2.1 12.7 18.8 0.6 13.2 1.4 0.6 33.0 0.9 1.4 0.3 0.9 0.9 1.3 1.1 0.7 1.1 6.2 4.7 1.0 2.1 0.4 1.3 0.8 0.6 11.3 0.2 0.4 9.5 3.2 1.6 0.2 5.7 0.5 0.0 0.8 0.2 0.4 0.4 0.8 4.9 0.2 1.8 0.9 1.0 0.0 0.2 3.2 0.7 0.3 0.4 0.2 0.3 0.4 1.8 1.0 1.1 0.1 0.7 0.1 0.0 2.8 1.0 0.7 0.1 2.5 0.3 0.5 9.5 0.1 0.1 0.3 0.0 0.2 0.0 17.3 29.0 17.5 3.2 1.4 2.4 1.0 0.2 1.9 0.2 0.3 0.9 0.4 1.3 1.6 8.8 0.7 2.2 0.5 1.7 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.3 0.0 0.1 0.3 0.2 0.9 0.1 0.1 0.4 0.0 0.1 15.3 18.6 15.5 20.7 19.6 5.5 15.6 5.4 13.2 1.1 4.7 11.3 0.1 0.0 1.1 20.9 0.1 0.4 2.1 0.6 1.2 18.4 1.5 2.3 0.8 0.0 0.1 0.0 27.1 0.1 0.2 0.1 0.0 0.2 8.0 0.2 0.6 0.1 13.9 0.0 61.7 0.4 0.1 1.1 0.0 0.3 0.0 0.1 0.0 0.0 0.1 13.5 56.9 0.5 6.1 0.0 0.6 5.4 0.9 0.1 0.0 4.7 0.0 4.1 0.0 44.7 22.8 0.0 0.1 0.4 1.2 0.7 0.0 0.4 0.0 58.6 0.0 1.3 0.7 9.8 3.1 0.7 0.1 0.0 0.1 0.2 0.0 0.6 AP4B1 "BETA-4, SPG47" ENSG00000134262 "Adaptor related protein complex 4 subunit beta 1" Q9Y6B7 1 113894194-113905201 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters" "Protein transport, Transport" "Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 31.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MCF7: 65.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028162, HPA028652" Approved Approved Vesicles NA NA "Cluster 46: Basophils - DNA binding" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 59: Non-specific - Transcription" Vesicles "HPA028162: AB_10610976, HPA028652: AB_10601451" "unprognostic (8.90e-2)" "unprognostic (2.25e-2)" "unprognostic (1.77e-1)" "unprognostic (2.40e-2)" "unprognostic (1.53e-1)" "unprognostic (5.01e-2)" "prognostic unfavorable (8.60e-7)" "unprognostic (3.45e-2)" "unprognostic (1.54e-2)" "unprognostic (8.34e-3)" "unprognostic (1.55e-1)" "unprognostic (2.07e-2)" "prognostic unfavorable (3.73e-6)" "unprognostic (5.08e-3)" "unprognostic (7.88e-2)" "unprognostic (3.12e-1)" "unprognostic (1.55e-2)" 9.7 8.5 12.5 11.1 13.1 20.5 9.3 14.6 14.6 11.9 10.9 11.5 10.6 9.7 14.2 12.1 11.0 7.0 11.2 13.0 13.0 9.7 8.4 9.5 14.3 11.6 11.4 13.7 14.0 4.8 13.7 5.9 11.8 9.6 12.7 20.0 7.6 6.2 11.7 11.5 12.8 9.1 11.5 20.1 10.4 11.1 13.3 16.1 11.0 9.1 13.9 9.2 10.0 13.3 11.0 9.8 10.0 11.8 15.7 14.1 6.4 10.1 9.8 13.0 14.0 6.8 7.7 21.5 15.9 12.4 6.5 9.7 11.3 13.4 16.5 16.6 9.8 17.6 13.6 8.3 9.5 19.6 17.3 16.1 6.7 25.5 15.3 7.8 22.7 20.9 12.3 18.5 17.6 65.2 15.6 21.6 9.4 7.7 19.0 15.0 19.5 13.3 13.2 5.5 10.2 8.5 10.1 19.1 7.8 9.5 5.7 15.4 21.8 15.0 13.9 17.4 20.8 15.2 15.8 21.3 24.6 26.0 25.1 15.9 10.5 8.6 14.7 10.8 15.6 9.5 11.7 12.6 12.9 11.9 12.7 11.1 1.2 12.2 8.5 9.1 10.4 9.5 12.5 13.1 14.6 14.6 13.0 13.0 11.6 11.4 11.8 11.5 13.3 13.3 7.2 3.2 6.7 7.5 12.3 3.6 3.3 5.4 4.6 6.8 3.2 4.3 8.7 5.7 11.9 3.7 31.3 3.8 12.0 7.8 1.9 7.7 3.6 4.6 4.7 7.6 3.0 18.1 11.4 26.8 3.5 7.0 11.2 5.2 2.5 4.5 7.5 4.1 5.2 8.4 11.6 5.3 6.1 7.3 4.9 2.3 2.8 6.9 7.2 7.5 6.1 4.7 3.1 11.6 10.0 10.9 6.9 4.9 7.4 2.8 6.5 3.3 5.2 21.0 13.1 6.1 6.2 16.4 11.5 5.7 3.7 1.6 14.8 6.4 9.0 3.3 AP4E1 "AP-4-EPSILON, SPG51" ENSG00000081014 "Adaptor related protein complex 4 subunit epsilon 1" Q9UPM8 15 50908672-51005895 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Protein transport, Transport" "Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Oligodendrocytes: 36.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "basophil: 2.7" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041749, HPA041891" Approved NA NA "Cluster 34: Basophils - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 32: U-937 - Innate immune response" "Cluster 59: Non-specific - Transcription" "HPA041749: AB_10794490, HPA041891: AB_10796462" "unprognostic (1.72e-2)" "unprognostic (3.44e-1)" "unprognostic (9.21e-2)" "unprognostic (2.22e-3)" "unprognostic (1.27e-1)" "unprognostic (9.46e-2)" "unprognostic (6.83e-3)" "unprognostic (1.06e-2)" "unprognostic (2.37e-2)" "unprognostic (1.01e-1)" "unprognostic (1.77e-1)" "unprognostic (6.84e-2)" "unprognostic (3.59e-2)" "unprognostic (1.09e-1)" "unprognostic (1.18e-1)" "unprognostic (3.40e-1)" "unprognostic (2.03e-2)" 3.7 3.0 2.5 4.4 2.9 3.1 3.0 3.3 2.7 3.7 3.2 3.6 3.0 4.3 2.1 4.7 3.2 2.6 3.9 2.4 2.6 2.8 2.9 3.1 5.5 2.9 2.8 2.9 2.2 5.1 2.4 4.7 2.9 2.7 3.4 3.8 3.3 2.6 8.2 5.4 3.2 4.5 2.6 4.6 2.9 3.9 3.0 6.5 3.8 6.3 4.7 4.0 4.1 3.5 11.5 8.7 6.0 7.1 7.9 12.0 11.7 11.1 8.9 10.7 11.1 10.7 1.8 11.2 4.3 12.5 10.8 13.7 9.0 9.6 12.4 12.3 4.6 9.8 14.5 4.3 11.1 12.1 8.2 12.2 11.6 13.4 21.0 6.6 7.2 8.8 9.1 6.3 14.7 15.4 7.1 6.9 3.9 5.2 4.4 9.7 8.5 6.9 7.9 10.4 4.1 6.7 11.8 8.4 8.7 10.7 7.6 11.7 10.0 15.7 5.8 9.5 15.9 9.6 11.7 14.1 12.3 26.1 7.3 2.7 0.6 0.3 0.8 0.9 0.5 0.5 0.6 0.7 0.6 0.3 0.4 0.9 0.1 0.5 0.5 0.4 0.3 0.4 2.5 2.9 3.3 2.7 2.4 2.6 2.9 2.8 2.9 2.6 3.0 3.5 6.6 6.4 6.1 17.6 8.7 5.7 1.5 3.8 4.0 9.8 4.9 3.7 10.4 2.8 8.4 5.5 18.8 7.3 7.7 7.9 0.0 4.9 2.0 5.9 10.0 7.8 3.0 6.9 26.7 4.8 5.7 4.7 7.1 6.2 10.2 7.2 6.8 8.1 7.2 8.4 27.0 5.3 2.0 17.0 4.1 1.4 5.9 10.2 1.8 25.3 6.5 3.9 8.2 19.1 36.0 10.6 2.4 4.1 9.6 2.2 6.2 3.6 4.8 11.2 6.6 7.1 6.6 10.2 7.7 6.6 7.0 7.3 9.6 4.8 5.5 2.4 AP4M1 "MU-4, MU-ARP2, SPG50" ENSG00000221838 "Adaptor related protein complex 4 subunit mu 1" O00189 7 100101549-100110345 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters" "Protein transport, Transport" "Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 95.9;Spermatocytes: 84.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA066774 Approved NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 43: Testis - Unknown function" "Cluster 38: EFO-21 - Unknown function" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA066774: AB_2685718" "unprognostic (6.40e-2)" "unprognostic (3.28e-1)" "unprognostic (1.78e-1)" "unprognostic (1.14e-1)" "unprognostic (7.22e-2)" "unprognostic (2.24e-3)" "prognostic unfavorable (7.63e-5)" "unprognostic (1.58e-2)" "unprognostic (6.98e-3)" "unprognostic (1.73e-1)" "unprognostic (3.05e-2)" "unprognostic (7.18e-2)" "prognostic unfavorable (8.29e-4)" "unprognostic (6.59e-2)" "unprognostic (1.25e-1)" "unprognostic (1.63e-1)" "unprognostic (1.46e-1)" 8.4 7.3 9.9 4.7 9.9 4.9 9.6 9.6 12.1 11.4 10.0 15.2 12.5 15.7 6.1 10.3 12.4 8.5 9.8 9.9 10.0 10.3 4.7 8.8 6.3 11.2 10.5 9.3 12.3 7.7 15.4 5.6 10.7 12.3 6.2 6.4 10.1 11.0 10.7 11.7 9.9 8.0 10.0 7.2 12.8 32.6 10.9 6.1 10.9 5.5 4.6 12.4 10.3 10.1 9.3 13.0 13.9 35.4 7.8 17.8 15.8 5.5 9.6 7.1 8.9 10.6 23.7 11.1 25.2 13.4 10.2 9.9 6.1 12.0 3.9 8.9 8.6 6.2 12.7 9.4 16.2 7.2 10.9 15.1 20.5 20.7 12.5 13.7 23.5 14.3 11.9 8.4 24.6 28.7 25.9 14.1 10.9 8.4 13.3 21.8 7.0 13.9 18.0 11.9 24.2 21.1 14.0 40.9 11.9 7.9 18.6 14.0 26.0 21.2 16.9 19.8 9.4 6.2 6.8 16.8 17.7 8.3 18.8 4.3 6.3 9.1 4.5 7.9 4.1 5.3 4.0 5.1 8.7 3.4 1.8 3.2 2.1 3.2 10.8 5.3 4.5 4.3 9.9 9.9 9.6 12.1 9.9 10.0 11.2 10.5 10.7 10.0 10.9 10.1 12.6 16.0 4.6 20.5 10.4 9.4 17.3 17.7 9.1 17.7 14.2 17.8 3.2 20.0 13.3 16.5 52.1 14.7 6.8 17.7 7.9 24.4 69.3 20.3 14.6 12.5 12.1 8.2 9.5 19.0 18.1 12.4 14.8 11.2 3.8 22.8 13.2 3.3 9.9 6.7 7.0 15.6 12.2 7.3 7.7 95.9 14.6 6.9 14.2 10.3 14.5 21.0 8.2 6.0 8.1 19.6 17.7 12.8 5.9 13.7 21.9 11.1 29.5 67.9 13.1 15.3 12.4 84.7 39.5 8.8 8.4 14.0 8.2 16.0 14.2 11.2 AP4S1 "AP47B, CLA20, SPG52" ENSG00000100478 "Adaptor related protein complex 4 subunit sigma 1" Q9Y587 14 31025106-31130996 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters" "Protein transport, Transport" "Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 36.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039963 Approved Supported Vesicles NA NA "Cluster 15: NK-cells - Transcription" "Cluster 21: Non-specific - Transcription" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 66: Spermatocytes - Spermatogenesis" Vesicles "HPA039963: AB_10795240" "unprognostic (4.03e-2)" "unprognostic (1.42e-1)" "unprognostic (1.65e-1)" "unprognostic (2.43e-1)" "unprognostic (1.14e-1)" "unprognostic (8.00e-3)" "unprognostic (1.03e-1)" "prognostic favorable (7.44e-4)" "unprognostic (3.79e-2)" "unprognostic (8.62e-3)" "unprognostic (1.15e-2)" "unprognostic (3.02e-1)" "prognostic favorable (2.87e-6)" "unprognostic (2.20e-3)" "unprognostic (5.44e-2)" "unprognostic (7.75e-2)" "unprognostic (5.59e-2)" 4.8 6.3 9.8 6.6 10.6 6.0 5.7 14.1 12.8 6.5 5.6 8.6 3.9 7.7 7.0 4.9 7.3 5.4 8.7 9.5 10.2 7.8 6.2 5.4 8.1 6.3 6.5 10.7 7.9 6.5 8.5 6.7 6.1 6.2 4.1 11.9 5.2 6.7 12.6 4.6 4.4 7.9 5.4 8.0 4.3 18.4 9.0 6.6 8.8 7.2 7.7 6.2 4.8 10.1 9.0 12.6 11.0 3.2 4.4 7.9 8.5 6.0 10.4 9.6 9.5 12.2 14.5 10.6 5.5 7.3 7.2 9.7 7.6 9.4 15.9 9.1 4.4 16.4 5.5 19.0 9.5 14.1 9.2 6.3 5.9 9.6 12.0 6.4 11.7 8.0 8.4 7.0 10.3 12.5 9.7 7.8 13.1 10.5 10.9 10.3 9.8 1.4 10.5 12.4 6.1 6.1 10.7 5.1 16.3 7.3 10.8 6.5 8.8 7.3 6.5 5.0 5.2 8.6 17.0 15.9 4.2 4.4 5.7 3.4 1.3 2.4 2.5 3.5 3.7 3.3 3.8 3.0 1.2 3.4 3.7 4.5 2.6 5.8 2.8 3.3 6.6 1.7 9.8 10.6 14.1 12.8 9.5 10.2 6.3 6.5 6.1 5.4 9.0 10.1 7.1 9.6 7.7 10.7 8.1 3.4 6.5 6.5 1.2 12.1 4.0 4.3 16.5 4.3 3.1 5.5 31.3 9.1 7.6 3.9 5.9 7.6 21.9 5.2 8.8 6.7 6.0 3.8 29.4 4.8 5.3 6.2 7.1 5.8 7.6 7.8 10.8 4.0 7.4 6.7 24.9 3.8 4.1 5.4 4.1 17.0 6.8 6.0 3.6 12.2 7.5 9.3 5.2 25.1 16.4 2.8 6.2 8.6 4.2 4.0 5.0 7.7 8.1 24.4 6.6 8.5 8.1 36.0 8.3 3.0 2.8 11.5 7.3 8.2 4.0 5.2 AP5Z1 "KIAA0415, SPG48, zeta" ENSG00000242802 "Adaptor related protein complex 5 subunit zeta 1" O43299 7 4775615-4794397 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "DNA damage, DNA repair, Protein transport, Transport" "Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "NB-4: 15.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA035693 Supported Supported "Nucleoplasm,Nuclear speckles" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 24: NB-4 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nuclear speckles" Nucleoplasm "HPA035693: AB_10960687" "unprognostic (1.64e-1)" "unprognostic (5.22e-2)" "unprognostic (3.01e-3)" "unprognostic (4.24e-2)" "unprognostic (2.43e-3)" "unprognostic (5.19e-1)" "prognostic unfavorable (1.35e-5)" "unprognostic (1.50e-1)" "unprognostic (2.03e-1)" "unprognostic (1.04e-1)" "unprognostic (1.10e-3)" "unprognostic (1.26e-2)" "unprognostic (5.32e-3)" "unprognostic (8.28e-2)" "unprognostic (1.71e-1)" "unprognostic (1.95e-2)" "unprognostic (2.22e-1)" 14.8 18.5 7.0 0.7 7.1 1.5 11.8 7.3 10.0 12.4 5.8 13.2 1.1 13.4 1.0 11.0 11.0 0.8 7.7 6.9 5.7 9.2 9.2 12.9 1.8 8.3 6.5 11.8 9.9 0.7 9.8 1.1 7.4 11.7 0.4 0.6 12.4 0.7 8.5 21.8 15.5 0.4 5.9 22.9 12.0 8.6 7.4 0.9 11.2 0.2 0.6 13.4 10.9 7.3 2.8 4.2 0.7 2.4 1.0 0.9 4.3 1.3 1.9 2.0 1.7 5.2 3.5 1.6 1.8 0.9 5.1 5.4 0.7 0.5 0.6 1.8 3.5 2.4 4.5 4.6 3.0 2.5 5.1 2.2 1.6 1.8 1.3 0.7 0.5 2.2 3.4 1.1 1.2 7.7 0.3 15.0 5.9 0.3 4.3 2.9 2.6 4.8 1.0 4.4 1.7 3.0 1.8 8.7 6.4 0.5 6.4 8.9 3.8 2.3 4.4 6.5 1.7 8.5 7.4 2.3 1.7 5.6 3.6 1.9 2.3 2.9 2.4 2.8 1.4 1.9 1.8 2.4 1.2 1.8 2.5 2.2 2.2 2.4 2.5 2.4 1.8 1.3 7.0 7.1 7.3 10.0 6.9 5.7 8.3 6.5 7.4 5.9 7.4 7.3 12.4 9.6 15.0 7.5 18.2 6.9 2.9 8.8 8.0 10.5 5.7 5.8 4.3 15.7 6.6 11.0 4.2 11.5 20.3 20.1 0.0 14.1 2.2 9.9 10.1 11.6 12.0 5.0 12.4 13.6 7.7 9.9 21.4 16.4 17.1 14.3 12.5 8.1 28.7 18.5 10.7 15.1 10.2 12.3 10.7 1.5 13.4 16.3 14.2 13.1 23.4 8.2 21.6 10.6 12.6 20.6 15.9 10.9 19.8 4.9 14.7 6.8 8.3 9.4 0.0 5.8 9.5 8.1 10.8 7.6 11.1 16.6 15.6 12.6 14.1 3.8 APOA1 ENSG00000118137 "Apolipoprotein A1" P02647 11 116835751-116837622 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport" "Amyloidosis, Atherosclerosis, Cancer-related genes, Disease variant, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "liver: 19248.5" "Group enriched" "Detected in many" 21 "Hepatocytes: 27332.1;Proximal enterocytes: 18348.1" "Cancer enriched" "Detected in many" 48 "liver cancer: 4515.8" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "plasmacytoid DC: 1.2" "Low lineage specificity" "Detected in single" "Cell line enriched" "Detected in many" 17 "Hep G2: 3460.4" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB016778, HPA046715" Supported Approved Vesicles,Cytosol "Secreted to blood" NA NA 1450000000000 110000000000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" Vesicles Cytosol "CAB016778: , HPA046715: AB_2679768" "unprognostic (1.88e-3)" "unprognostic (4.53e-2)" "unprognostic (7.46e-2)" "unprognostic (4.00e-3)" "unprognostic (3.70e-2)" "unprognostic (1.41e-1)" "prognostic favorable (5.05e-4)" "unprognostic (5.40e-2)" "unprognostic (1.89e-1)" "unprognostic (9.60e-3)" "unprognostic (1.59e-3)" "unprognostic (7.02e-2)" "prognostic unfavorable (1.67e-8)" "unprognostic (3.46e-3)" "unprognostic (1.15e-1)" "unprognostic (6.24e-2)" "unprognostic (9.54e-2)" 3.2 1.4 1.2 3.6 1.2 0.0 2.1 1.1 1.4 0.8 0.8 7.4 1709.3 3.5 0.4 1.1 6.1 1.7 67.2 1.0 1.1 3.7 19248.5 2.7 3.2 1.1 1.1 23.1 2.5 0.0 4.2 1.6 1.1 1.1 0.2 0.1 0.7 1.0 0.8 1.0 4053.7 2.1 1.1 9.0 14.6 384.5 1.2 0.9 3.7 0.2 0.1 0.5 1.5 1.2 0.0 0.0 0.6 0.1 0.0 0.0 15.0 0.0 0.0 0.0 0.0 203.4 0.3 3.1 6.0 0.0 0.0 0.6 0.0 0.0 0.0 0.1 0.1 7.3 1.9 3460.4 0.0 16.6 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.3 0.0 0.2 0.3 15.0 1.2 1.2 0.1 0.5 15.0 20.3 0.0 2.6 5.7 20.7 8.9 0.0 0.0 3.9 0.0 0.1 2.6 0.0 0.4 2.1 0.1 1.2 0.2 4.9 0.0 5.5 0.2 0.0 0.0 0.0 0.8 0.2 0.0 0.0 0.0 0.5 0.2 0.1 0.2 0.5 0.0 0.2 0.0 1.2 0.6 0.1 1.2 1.2 1.1 1.4 1.0 1.1 1.1 1.1 1.1 1.1 1.2 1.2 2.0 3.2 3.3 0.3 49.7 0.1 0.5 0.2 0.6 0.5 0.9 0.9 37.0 479.0 1.3 0.0 0.0 0.6 5.1 0.4 0.0 0.1 36.9 15.2 4.3 50.3 1.8 541.9 0.5 1.1 4.2 5.8 17.9 1.7 2.5 419.2 458.7 27332.1 3.3 0.0 0.8 458.8 0.0 681.2 2.0 149.7 22.4 2.1 0.0 0.0 0.0 0.3 3.1 0.0 0.3 0.3 458.2 4.9 1.0 0.1 18348.1 9.0 0.4 0.6 6.6 1.6 13.0 39.8 11.2 0.0 0.6 4.2 35.7 1051.7 175.7 0.3 APOE AD2 ENSG00000130203 "Apolipoprotein E" P02649 19 44905791-44909393 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted secreted proteins" "Cholesterol metabolism, Host-virus interaction, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport" Heparin-binding "Alzheimer disease, Amyloidosis, Cancer-related genes, Disease variant, Hyperlipidemia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 4 "adrenal gland: 3453.9;liver: 6592.5" "Cell type enhanced" "Detected in many" "Hepatocytes: 9363.4;Hofbauer cells: 6072.6;Muller glia cells: 9454.8;Peritubular cells: 4958.2;Proximal tubular cells: 8155.9;Theca cells: 7201.0" "Cancer enhanced" "Detected in all" "liver cancer: 3183.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 1867.0;CACO-2: 466.1;Hep G2: 935.3;HSkMC: 1374.2;SK-MEL-30: 1956.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008363, HPA065539, HPA068768, CAB069921" Enhanced Approved Vesicles "Secreted to blood" NA NA 51800000000 29000000000 "Cluster 15: Liver - Metabolism" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 10: Non-specific - Unknown function" Vesicles "CAB008363: AB_590560, CAB069921: AB_920623, HPA065539: AB_2685509, HPA068768: AB_2686029" "unprognostic (8.98e-2)" "unprognostic (2.32e-2)" "unprognostic (2.49e-2)" "unprognostic (5.28e-2)" "unprognostic (3.77e-2)" "unprognostic (7.25e-2)" "unprognostic (5.22e-3)" "unprognostic (6.13e-2)" "unprognostic (5.06e-2)" "unprognostic (4.13e-1)" "unprognostic (5.78e-2)" "unprognostic (1.38e-1)" "unprognostic (1.74e-1)" "unprognostic (7.76e-2)" "unprognostic (1.64e-1)" "unprognostic (1.12e-3)" "unprognostic (4.13e-2)" 522.1 3453.9 813.4 92.8 1164.2 66.5 325.1 775.0 943.2 271.2 329.2 130.9 40.3 81.5 20.0 37.2 72.2 100.2 176.3 606.1 841.6 1066.0 6592.5 258.8 352.2 1016.0 1037.0 508.2 41.9 34.5 110.9 102.2 1106.9 45.4 22.9 87.6 80.5 10.8 31.1 381.2 165.9 12.6 823.2 620.3 83.3 140.5 962.6 57.8 146.4 10.4 46.1 93.4 135.5 964.4 3.2 5.2 9.5 2.6 1867.0 76.3 69.4 1.5 4.3 8.4 1.4 466.1 2.8 2.0 9.9 0.3 9.1 6.4 12.6 2.1 0.7 1.7 4.0 3.3 1.7 935.3 192.4 6.8 2.3 1374.2 2.5 14.8 1.3 15.6 1.0 0.7 124.9 2.8 1.2 3.3 1.9 2.5 243.2 3.0 1.3 2.6 8.0 1.8 2.8 0.9 5.6 2.4 4.5 1.4 1956.0 131.6 165.3 52.8 3.3 13.2 3.1 1.4 1.6 5.9 8.6 3.8 5.9 4.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 813.4 1164.2 775.0 943.2 606.1 841.6 1016.0 1037.0 1106.9 823.2 962.6 964.4 136.7 0.0 8.2 444.0 66.1 935.2 12.3 18.3 67.7 81.7 86.7 565.8 2.2 450.4 5.2 228.1 41.7 46.3 6.0 2.2 682.9 1.8 73.6 33.8 936.6 140.2 0.0 331.6 1.1 0.7 43.8 860.7 3.6 22.9 174.4 103.6 208.9 9363.4 6072.6 38.7 2.1 0.6 4.1 718.0 292.6 355.3 2629.4 940.6 2481.3 60.9 70.3 9454.8 0.0 12.1 2.2 0.6 0.3 4958.2 7.2 15.0 0.2 8155.9 1.0 311.4 223.5 2958.4 345.5 14.8 12.8 15.1 1684.9 74.3 60.6 7201.0 1.7 4.7 APP AD1 ENSG00000142192 "Amyloid beta precursor protein" P05067 21 25880550-26171128 "Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters" "Apoptosis, Cell adhesion, Endocytosis, Notch signaling pathway" "Heparin-binding, Protease inhibitor, Serine protease inhibitor" "Alzheimer disease, Amyloidosis, Disease variant, FDA approved drug targets, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 870.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "plasmacytoid DC: 38.1" "Lineage enriched" "Detected in many" 5 "dendritic cells: 38.1" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000157, HPA001462" Enhanced Approved "Golgi apparatus,Vesicles" "Secreted to blood" NA NA 26000000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 7: Kidney - Transmembrane transport" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Golgi apparatus" Vesicles "CAB000157: AB_323833, HPA001462: AB_1078185" "unprognostic (3.30e-1)" "unprognostic (1.02e-2)" "unprognostic (1.90e-1)" "unprognostic (1.24e-1)" "unprognostic (1.92e-1)" "unprognostic (3.69e-3)" "unprognostic (2.54e-1)" "unprognostic (8.22e-2)" "unprognostic (1.28e-1)" "unprognostic (9.45e-2)" "unprognostic (4.28e-2)" "unprognostic (5.35e-2)" "prognostic favorable (2.79e-6)" "unprognostic (3.77e-2)" "unprognostic (2.46e-1)" "unprognostic (5.23e-2)" "unprognostic (2.08e-3)" 249.9 498.0 413.0 157.4 457.6 134.4 447.5 413.1 572.4 264.2 396.8 357.2 226.4 281.1 293.3 178.6 308.1 350.8 389.0 456.2 405.3 532.5 298.2 279.4 78.9 425.0 481.9 306.2 323.5 278.6 155.4 451.9 448.7 260.6 328.5 209.3 270.7 343.6 107.5 218.6 200.3 379.9 419.7 154.4 213.5 165.6 426.4 159.2 469.9 176.0 78.2 304.9 151.7 523.5 388.7 489.9 538.4 448.5 707.7 869.8 559.8 757.1 1029.2 386.6 449.3 286.4 941.0 0.9 848.3 614.8 505.1 255.6 326.4 921.6 324.4 14.7 253.1 0.8 275.6 204.1 688.0 372.0 19.6 790.4 990.7 456.8 823.0 1584.3 1750.7 158.6 0.8 39.0 614.5 433.1 6.5 4.0 416.2 644.9 418.6 241.2 505.2 325.3 1283.3 270.1 267.3 385.6 824.0 549.0 393.4 720.0 482.4 400.1 1837.1 850.8 350.2 310.4 371.6 232.3 3.1 4.8 690.4 1.6 836.3 1.1 7.5 0.0 0.2 2.2 0.3 0.8 2.2 0.7 5.6 2.2 2.3 0.6 1.5 0.5 1.6 38.1 0.6 3.3 413.0 457.6 413.1 572.4 456.2 405.3 425.0 481.9 448.7 419.7 426.4 523.5 330.2 109.0 39.6 70.5 47.6 181.6 215.6 449.0 306.7 45.2 280.3 199.6 143.2 296.0 214.0 502.1 29.2 472.6 180.7 395.2 56.7 398.7 46.1 78.8 162.2 416.0 162.6 29.2 481.6 180.4 141.2 309.5 164.7 110.7 8.2 100.3 539.7 125.7 76.3 84.1 525.5 303.1 256.3 61.6 79.9 61.8 242.6 69.9 161.9 189.3 89.9 329.9 4.1 423.2 870.8 205.4 223.1 296.8 24.0 187.5 95.2 165.8 164.7 24.5 118.3 336.5 198.5 38.3 86.9 85.9 106.1 552.1 27.0 111.4 283.5 133.6 APTX "AOA, AOA1, AXA1, EAOH, EOAHA, FLJ20157" ENSG00000137074 Aprataxin Q7Z2E3 9 32886601-33025130 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair" "DNA-binding, Hydrolase" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA064930 Supported Supported Nucleoplasm,Nucleoli No No "Cluster 27: Non-specific - Gene expression" "Cluster 27: Brain & Skin - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 23: Spermatids - Flagellum & Golgi organization" "Nucleoplasm, Nucleoli" "HPA064930: AB_2685386" "unprognostic (9.18e-2)" "unprognostic (2.65e-2)" "unprognostic (3.61e-2)" "unprognostic (1.73e-2)" "unprognostic (4.04e-1)" "unprognostic (8.16e-2)" "unprognostic (2.26e-2)" "unprognostic (1.00e-1)" "unprognostic (1.32e-2)" "unprognostic (2.78e-3)" "unprognostic (3.48e-3)" "unprognostic (3.49e-2)" "prognostic favorable (6.01e-5)" "unprognostic (7.87e-2)" "unprognostic (1.34e-1)" "unprognostic (1.13e-1)" "unprognostic (6.50e-2)" 9.7 14.8 14.6 7.0 14.8 11.0 10.4 14.8 20.2 9.1 13.9 10.2 8.6 8.6 7.6 14.7 8.9 4.9 9.9 14.8 15.0 13.6 15.6 9.3 8.1 14.7 14.6 8.5 9.6 12.1 7.6 7.8 15.0 9.6 11.2 8.0 9.0 6.6 9.8 15.3 8.3 8.6 14.2 8.9 9.7 14.7 15.2 9.3 7.0 6.9 11.0 10.4 9.6 15.0 36.2 26.1 18.4 17.1 19.0 17.4 25.6 24.8 26.0 28.7 31.5 35.1 12.7 27.8 14.6 21.1 18.4 19.4 33.7 32.8 35.1 39.2 11.2 17.9 32.5 37.8 24.4 29.4 15.1 23.8 36.3 32.5 37.9 16.9 26.8 20.2 27.0 24.2 26.0 15.6 24.4 43.2 33.5 24.4 29.0 21.2 14.4 21.5 25.2 21.2 15.6 11.1 21.4 18.0 15.5 17.9 23.0 11.4 17.7 16.2 21.1 29.9 25.0 11.1 21.2 27.5 23.4 23.8 13.2 3.3 14.7 13.4 12.2 15.6 15.2 16.3 12.8 14.6 17.6 16.1 16.0 12.1 5.9 23.1 21.7 15.2 17.3 16.1 14.6 14.8 14.8 20.2 14.8 15.0 14.7 14.6 15.0 14.2 15.2 15.0 14.8 19.2 29.0 31.3 16.9 16.7 23.1 32.9 22.2 15.2 17.9 17.0 14.9 21.5 23.1 9.2 10.4 27.7 15.1 12.6 29.4 25.3 55.6 19.7 18.3 13.3 16.8 20.0 27.3 28.2 27.7 15.6 19.4 18.1 16.5 17.8 8.9 21.4 18.8 13.5 29.0 15.3 34.6 14.7 9.9 48.7 13.4 15.0 14.2 15.9 19.3 18.3 15.5 23.6 43.0 31.9 6.8 10.5 28.3 24.0 13.9 31.7 25.4 16.6 13.1 13.5 20.2 42.2 26.9 25.8 21.2 27.9 15.9 20.5 16.3 23.1 AQP4 MIWC ENSG00000171885 "Aquaporin 4" P55087 18 26852043-26865771 "Human disease related genes, Metabolic proteins, Predicted membrane proteins, Transporters" Transport "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 440.5;lung: 114.8" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 1102.6;Alveolar cells type 2: 342.3;Astrocytes: 487.7;Muller glia cells: 227.2" "Cancer enriched" "Detected in some" 22 "glioma: 223.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 2.4;RPTEC TERT1: 1.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005079, HPA014784, CAB058689" Enhanced Supported Supported "Plasma membrane,Cell Junctions" NA NA "Cluster 70: Brain - Nervous system development" "Cluster 12: NES - Nervous system development" "Cluster 11: Alveolar cells - Smell perception" "Plasma membrane" "Cell Junctions" "CAB005079: AB_2274338, CAB058689: AB_2665579, HPA014784: AB_1844967" "unprognostic (7.23e-5)" "unprognostic (1.55e-1)" "unprognostic (3.19e-8)" "unprognostic (3.68e-1)" "unprognostic (1.96e-1)" "unprognostic (2.69e-2)" "unprognostic (1.74e-1)" "unprognostic (2.34e-1)" "unprognostic (5.38e-3)" "unprognostic (1.64e-3)" "unprognostic (8.98e-2)" "unprognostic (1.22e-1)" "unprognostic (4.14e-2)" "unprognostic (1.35e-1)" "unprognostic (4.10e-2)" 0.1 0.1 272.7 0.0 298.7 0.0 0.3 282.0 246.3 0.6 62.9 0.3 0.0 0.0 0.8 0.9 1.1 0.1 2.8 283.6 440.5 2.3 0.9 114.8 0.3 250.5 351.2 2.5 0.2 2.2 3.7 0.0 333.3 0.4 0.0 60.2 0.7 0.2 60.1 0.1 0.1 0.0 333.0 0.5 11.4 0.5 387.1 0.2 14.7 20.9 0.1 0.1 0.1 376.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.2 0.1 0.3 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.7 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 272.7 298.7 282.0 246.3 283.6 440.5 250.5 351.2 333.3 333.0 387.1 376.0 0.0 1102.6 342.3 487.7 0.0 0.0 0.8 0.6 0.0 3.1 0.8 0.9 13.9 4.3 76.6 3.7 6.2 0.0 0.0 0.1 3.9 0.3 0.0 0.7 0.1 1.8 0.0 0.0 3.0 0.0 0.0 0.8 0.0 0.0 3.8 0.0 0.0 0.5 0.0 1.7 1.1 0.0 0.0 0.0 0.3 0.0 5.0 0.8 0.0 9.4 0.0 227.2 0.0 12.1 1.6 0.0 0.0 0.0 0.0 0.7 0.0 0.0 23.1 9.1 0.0 4.3 0.1 0.0 0.0 0.0 0.0 0.1 1.1 0.0 0.0 2.0 AR "AIS, DHTR, HUMARA, NR3C4, SBMA, SMAX1" ENSG00000169083 "Androgen receptor" P10275 X 67544021-67730619 "Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding, Receptor" "Cancer-related genes, Disease variant, FDA approved drug targets, Neurodegeneration, Pseudohermaphroditism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 38.2" "Cell type enhanced" "Detected in many" "Breast glandular cells: 93.7;Granulosa cells: 104.8;Hepatocytes: 269.2;Leydig cells: 77.9;Peritubular cells: 86.5;Skeletal myocytes: 75.0" "Cancer enhanced" "Detected in many" "breast cancer: 15.6;prostate cancer: 16.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 13.3;BJ hTERT+: 10.3;HAP1: 14.9;LHCN-M2: 16.1;RH-30: 23.6;T-47d: 10.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB000001, HPA004733, CAB065764" Enhanced Supported Cytosol NA NA "Cluster 85: Liver - Metabolism" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 35: Glandular cells - Unknown function" Cytosol "CAB000001: AB_2060174, CAB065764: AB_10620739, HPA004733: " "unprognostic (1.34e-1)" "unprognostic (8.10e-3)" "unprognostic (2.49e-2)" "unprognostic (5.95e-2)" "unprognostic (1.04e-2)" "unprognostic (3.35e-2)" "prognostic favorable (8.77e-4)" "unprognostic (4.99e-2)" "unprognostic (1.72e-1)" "unprognostic (7.79e-2)" "unprognostic (2.30e-1)" "unprognostic (2.29e-1)" "prognostic favorable (1.03e-8)" "unprognostic (8.23e-3)" "unprognostic (8.90e-2)" "unprognostic (4.23e-2)" "unprognostic (7.97e-2)" 6.7 1.0 1.1 0.5 1.3 0.0 8.7 1.7 1.1 23.6 0.2 2.0 0.2 18.6 16.1 1.2 20.7 2.0 5.8 1.0 3.5 3.6 38.2 1.5 0.3 3.5 2.6 14.6 0.8 0.1 1.9 0.1 2.7 16.5 0.6 0.2 1.4 18.2 13.9 5.2 0.9 9.5 2.1 1.3 1.5 3.9 4.8 2.7 2.1 6.1 0.5 3.5 12.9 2.0 0.0 4.8 13.3 0.0 0.0 0.0 0.0 7.3 10.3 0.3 0.1 0.1 0.0 0.0 0.0 1.0 0.0 0.0 14.9 0.0 0.0 0.0 2.4 0.0 1.5 0.0 0.8 0.0 0.0 5.5 0.0 1.8 0.0 0.0 3.9 0.1 4.6 2.2 16.1 1.5 0.0 0.0 5.4 0.0 0.0 0.0 23.6 0.1 0.4 0.0 0.0 0.0 0.0 0.3 0.0 3.6 10.9 7.6 0.3 0.3 2.2 0.0 3.5 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 1.3 1.7 1.1 1.0 3.5 3.5 2.6 2.7 2.1 4.8 2.0 3.1 0.0 5.0 28.4 0.4 9.7 17.8 0.2 15.9 0.7 93.7 33.7 37.4 14.3 10.7 3.7 0.0 3.5 14.0 0.0 1.9 11.3 1.1 2.9 49.1 10.5 0.0 5.3 7.7 0.0 0.2 39.4 0.0 5.8 1.3 104.8 36.0 269.2 0.8 0.0 17.8 0.3 0.0 2.2 4.2 4.4 77.9 3.3 10.6 1.0 1.7 0.2 0.0 26.7 0.2 0.6 0.0 86.5 0.0 36.5 0.6 27.7 3.6 0.3 65.7 75.0 20.8 0.8 3.3 12.7 16.1 1.0 1.7 37.8 0.2 22.0 ARHGEF18 "KIAA0521, MGC15913, P114-RhoGEF, p114RhoGEF" ENSG00000104880 "Rho/Rac guanine nucleotide exchange factor 18" Q6ZSZ5 19 7348937-7472485 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Guanine-nucleotide releasing factor" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 17.0;Excitatory neurons: 22.2;Inhibitory neurons: 18.0;Microglial cells: 14.0;Oligodendrocyte precursor cells: 18.1;Oligodendrocytes: 30.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042689, HPA049151, HPA071867" Approved Enhanced Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 14: B-cells - Humoral immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "HPA042689: AB_10794385, HPA049151: AB_2680654, HPA071867: AB_2686466" "unprognostic (2.55e-1)" "unprognostic (1.31e-2)" "unprognostic (1.57e-1)" "unprognostic (6.01e-2)" "unprognostic (1.65e-2)" "prognostic favorable (4.21e-4)" "unprognostic (1.13e-1)" "unprognostic (1.52e-3)" "unprognostic (3.56e-1)" "unprognostic (2.36e-1)" "unprognostic (1.40e-1)" "unprognostic (8.26e-2)" "prognostic favorable (3.11e-5)" "unprognostic (1.08e-1)" "unprognostic (2.21e-1)" "unprognostic (1.42e-1)" "unprognostic (3.79e-3)" 8.2 15.9 10.4 20.0 13.3 27.1 8.1 9.7 12.1 12.2 7.0 22.1 13.3 16.8 3.1 19.9 9.7 10.7 7.1 9.8 8.8 24.1 13.1 14.6 29.8 12.1 13.0 10.1 21.0 11.2 15.8 7.8 10.8 14.2 7.7 5.0 11.0 7.3 5.3 13.8 31.1 13.9 9.5 35.9 22.6 8.9 12.2 33.1 10.8 3.0 17.5 14.0 12.1 15.3 31.2 17.9 10.2 13.9 9.4 7.8 30.8 13.4 12.9 20.5 20.8 24.5 17.4 62.9 29.4 15.2 15.3 24.6 12.7 29.7 11.8 37.6 16.1 15.5 11.7 16.4 22.1 31.2 30.4 12.8 20.2 19.7 16.3 10.1 11.2 20.2 13.4 14.7 21.3 11.0 36.0 26.8 16.0 16.9 29.2 42.2 17.6 17.2 9.0 34.6 9.8 13.7 16.4 16.1 18.8 9.6 17.4 36.4 21.9 16.8 20.1 25.9 17.2 35.6 23.2 40.2 16.7 27.5 15.1 6.4 3.7 23.0 3.9 4.5 4.0 8.8 5.3 4.3 2.3 12.4 5.4 4.1 12.5 0.9 6.9 2.8 3.9 3.5 10.4 13.3 9.7 12.1 9.8 8.8 12.1 13.0 10.8 9.5 12.2 15.3 0.2 0.0 1.1 17.0 2.2 2.9 0.0 6.5 2.8 0.2 0.4 0.1 0.2 0.0 4.3 0.0 4.2 0.1 0.3 0.5 0.0 0.3 0.1 2.4 0.8 0.5 1.8 3.0 22.2 0.4 0.1 1.1 6.1 2.9 0.0 0.5 0.0 0.0 0.2 0.0 18.0 0.0 4.1 0.3 2.1 0.1 0.0 1.6 1.8 14.0 0.7 0.0 0.0 18.1 30.5 0.6 2.3 0.0 4.3 0.0 0.7 0.1 9.3 0.4 0.0 0.1 1.2 0.0 0.0 3.9 3.8 0.0 1.6 0.0 0.0 0.3 ARHGEF9 "KIAA0424, PEM-2" ENSG00000131089 "Cdc42 guanine nucleotide exchange factor 9" O43307 X 63634967-63809274 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Guanine-nucleotide releasing factor" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "retina: 88.1" "Cell type enhanced" "Detected in many" "Bipolar cells: 184.3;Cone photoreceptor cells: 233.5;Rod photoreceptor cells: 320.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "RH-30: 48.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035419, HPA055291" Approved Supported Cytosol NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 58: Brain - Synaptic function" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 9: Photoreceptor cells - Phototransduction" Cytosol "HPA035419: AB_10669859, HPA055291: AB_2682774" "unprognostic (3.19e-1)" "unprognostic (6.15e-2)" "unprognostic (4.02e-2)" "unprognostic (2.67e-2)" "unprognostic (2.10e-1)" "unprognostic (2.14e-1)" "unprognostic (1.66e-1)" "unprognostic (1.98e-3)" "unprognostic (1.33e-2)" "unprognostic (3.79e-2)" "unprognostic (1.08e-3)" "unprognostic (1.67e-1)" "prognostic favorable (1.02e-5)" "unprognostic (4.56e-2)" "unprognostic (9.27e-2)" "unprognostic (3.15e-2)" "unprognostic (8.98e-2)" 7.7 15.6 32.6 6.4 39.3 4.1 10.6 5.1 51.0 8.4 5.2 13.6 15.8 9.3 7.1 11.2 7.7 8.0 35.9 46.2 36.6 13.2 5.6 6.3 6.3 13.1 14.3 16.2 5.2 15.0 15.7 5.8 14.3 13.8 14.3 88.1 6.3 14.6 5.9 9.1 13.4 17.2 10.0 6.9 8.9 2.8 26.7 9.5 8.2 8.9 7.3 14.3 6.5 27.2 6.3 9.7 20.2 10.3 7.6 11.1 1.2 12.3 11.8 12.8 9.8 0.6 6.8 14.1 8.7 8.0 10.8 0.2 8.4 14.5 15.1 18.5 6.6 13.7 4.5 0.6 4.5 6.7 4.2 12.2 6.9 5.9 18.5 11.9 7.1 14.8 1.5 20.8 14.0 10.0 12.6 3.3 16.4 6.2 12.1 22.9 48.2 13.5 7.8 6.0 0.1 5.1 5.6 9.8 6.7 8.4 7.5 8.9 3.4 7.1 6.4 34.6 5.1 7.8 6.5 10.2 8.7 10.7 5.1 0.8 1.4 1.3 4.5 2.0 3.2 2.2 2.7 3.1 2.2 2.9 3.3 2.9 1.1 8.4 1.4 1.8 2.6 1.9 32.6 39.3 5.1 51.0 46.2 36.6 13.1 14.3 14.3 10.0 26.7 27.2 9.2 9.6 11.4 59.4 20.3 5.7 6.5 8.7 12.5 184.3 26.0 17.4 45.9 7.2 10.0 11.0 233.5 5.0 19.4 18.2 13.7 6.3 2.0 6.5 9.8 10.8 20.9 3.8 105.9 8.8 1.4 11.8 24.5 6.0 14.5 20.0 11.7 10.7 10.5 82.4 90.5 16.0 12.2 5.7 6.3 6.2 15.5 8.2 14.2 33.7 3.8 29.9 34.0 89.0 50.5 7.9 14.5 15.4 12.4 4.3 19.1 17.3 9.3 320.8 0.0 12.7 22.0 1.9 3.4 11.2 6.0 4.4 21.8 39.6 21.8 6.1 ARL2BP "BART, BART1, RP66" ENSG00000102931 "ADP ribosylation factor like GTPase 2 binding protein" Q9Y2Y0 16 57245259-57253635 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Ciliopathy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 264.6;Late spermatids: 503.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043066, HPA048440" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 44: Non-specific - Transcription" "Cluster 43: Testis - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 34: Spermatids - Unknown function" "Nucleoplasm, Cytosol" "HPA043066: AB_2678302, HPA048440: AB_2680393" "unprognostic (1.17e-1)" "unprognostic (4.05e-2)" "unprognostic (3.32e-2)" "unprognostic (1.74e-1)" "unprognostic (3.33e-3)" "unprognostic (1.26e-2)" "unprognostic (1.47e-1)" "prognostic unfavorable (9.06e-5)" "unprognostic (2.38e-1)" "unprognostic (3.06e-1)" "unprognostic (2.07e-1)" "unprognostic (4.10e-2)" "unprognostic (2.71e-3)" "unprognostic (1.44e-1)" "unprognostic (1.58e-1)" "unprognostic (1.47e-2)" "unprognostic (6.78e-2)" 48.5 42.6 49.8 30.1 51.6 35.7 37.4 51.1 58.1 35.5 51.9 36.0 20.8 45.0 34.8 49.6 44.1 36.2 54.4 51.5 52.2 44.0 32.7 44.5 37.7 50.1 51.9 50.6 29.6 48.0 27.6 37.4 51.6 34.9 36.0 37.2 25.4 46.0 31.8 31.3 24.8 59.3 51.1 49.4 27.5 57.1 51.6 44.8 29.9 46.1 46.3 39.9 29.9 52.1 74.2 49.4 93.3 48.7 82.6 106.0 23.2 91.2 105.4 104.2 65.9 37.4 28.9 61.9 104.0 126.3 48.8 48.5 60.3 74.0 97.8 28.5 57.8 54.9 36.3 64.2 112.3 50.8 113.6 91.6 94.8 75.4 103.3 77.4 127.5 46.7 42.5 23.3 73.0 28.7 52.3 63.9 32.7 25.7 98.7 71.3 91.7 120.8 113.8 26.4 29.2 61.1 140.1 66.1 82.8 58.1 48.8 66.6 114.6 61.2 37.8 53.3 70.8 58.8 49.6 58.9 79.8 33.2 60.2 35.5 46.1 27.3 40.5 45.3 42.3 37.6 36.7 44.1 56.5 29.8 49.5 42.0 7.6 63.6 51.3 16.3 33.7 55.1 49.8 51.6 51.1 58.1 51.5 52.2 50.1 51.9 51.6 51.1 51.6 52.1 60.3 51.3 27.4 9.8 47.0 36.7 43.3 57.0 42.7 44.4 30.6 27.8 0.2 40.0 28.7 36.8 4.2 51.0 50.5 23.4 76.3 46.2 264.6 49.2 57.8 63.7 26.4 105.7 20.6 58.0 30.2 66.6 30.1 58.7 74.3 105.7 62.8 34.3 63.3 55.5 22.5 21.5 46.8 52.8 36.5 503.7 82.3 42.2 48.0 7.5 71.2 66.0 66.9 42.7 33.9 44.6 18.5 109.1 50.3 24.0 23.2 65.8 32.9 38.0 13.1 39.7 45.5 122.2 51.8 66.8 37.1 22.3 60.8 170.2 23.6 22.6 ARL3 ARFL3 ENSG00000138175 "ADP ribosylation factor like GTPase 3" P36405 10 102673731-102714397 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cell cycle, Cell division, Protein transport, Transport" "Ciliopathy, Disease variant, Joubert syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "retina: 96.3" "Cell type enhanced" "Detected in all" "Muller glia cells: 289.1;Rod photoreceptor cells: 318.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036292, HPA063596" Approved Supported Nucleoplasm,Centrosome NA NA 44000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 77: Retina - Visual perception" "Cluster 6: T47d - Mammary gland" "Cluster 46: Photoreceptor cells - Phototransduction" Centrosome Nucleoplasm "HPA036292: AB_10673618, HPA063596: AB_2685053" "unprognostic (1.36e-1)" "unprognostic (2.89e-3)" "unprognostic (4.19e-2)" "unprognostic (7.58e-2)" "unprognostic (2.98e-2)" "unprognostic (3.24e-2)" "unprognostic (2.45e-2)" "unprognostic (7.69e-2)" "unprognostic (4.00e-2)" "unprognostic (3.21e-1)" "unprognostic (3.99e-3)" "unprognostic (5.58e-2)" "prognostic favorable (1.71e-6)" "unprognostic (5.62e-2)" "unprognostic (3.09e-2)" "unprognostic (4.21e-2)" "unprognostic (1.03e-1)" 8.1 8.9 20.2 4.2 21.3 1.7 8.1 20.8 25.1 12.4 19.1 11.3 4.2 11.5 10.6 4.6 15.2 5.2 13.5 20.8 19.5 15.4 5.2 8.3 3.6 19.3 19.1 16.8 6.4 19.8 21.0 4.9 19.7 8.7 4.6 96.3 6.3 9.0 5.6 7.2 6.1 8.7 18.5 4.5 8.8 11.0 20.5 5.7 11.4 5.9 4.7 9.8 8.3 19.5 14.7 25.0 33.6 24.7 15.2 22.7 5.9 11.4 17.3 13.6 14.7 8.7 7.4 6.1 10.8 18.5 16.4 10.7 12.7 15.3 16.9 16.1 13.4 9.9 16.9 8.3 16.4 4.6 9.5 11.5 12.6 18.8 11.0 36.1 15.8 12.0 4.5 6.0 23.0 15.1 9.5 7.3 13.0 9.2 9.8 7.9 24.8 5.4 18.1 7.7 11.8 25.7 8.7 1.8 14.1 18.5 45.1 4.6 9.1 9.2 12.9 18.9 16.0 4.2 8.9 11.3 24.4 13.6 8.1 2.0 7.2 2.6 3.7 6.1 9.4 4.5 6.5 5.5 7.1 3.9 3.9 4.7 13.4 4.4 5.4 5.2 4.9 5.4 20.2 21.3 20.8 25.1 20.8 19.5 19.3 19.1 19.7 18.5 20.5 19.5 46.0 54.5 39.3 47.7 16.7 32.1 70.4 144.3 29.0 167.6 48.2 57.5 135.5 31.5 85.8 62.5 116.7 45.5 12.1 9.4 234.8 70.7 46.5 250.5 85.2 41.6 74.8 9.4 30.8 43.6 37.8 61.7 19.4 84.6 33.0 94.1 43.9 25.5 64.7 97.6 37.6 31.6 73.2 16.4 33.6 25.8 60.6 26.8 76.5 13.1 67.3 289.1 13.4 31.7 23.4 31.1 13.5 104.2 18.6 54.2 23.1 225.8 268.3 318.6 26.3 50.8 122.0 145.6 43.4 11.9 31.7 32.3 20.8 58.6 25.4 50.5 ARL6 "BBS3, RP55" ENSG00000113966 "ADP ribosylation factor like GTPase 6" Q9H0F7 3 97764521-97801229 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cilium biogenesis/degradation, Protein transport, Sensory transduction, Transport, Vision" "Bardet-Biedl syndrome, Ciliopathy, Disease variant, Mental retardation, Obesity, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "retina: 46.3" "Cell type enhanced" "Detected in many" "Excitatory neurons: 55.0;Inhibitory neurons: 51.5;Rod photoreceptor cells: 57.4;Spermatocytes: 39.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "SCLC-21H: 26.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019361 Approved Approved Microtubules NA NA "Cluster 15: NK-cells - Transcription" "Cluster 77: Retina - Visual perception" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 46: Photoreceptor cells - Phototransduction" Microtubules "HPA019361: AB_1845028" "unprognostic (1.31e-1)" "unprognostic (2.82e-2)" "unprognostic (7.12e-2)" "unprognostic (4.66e-2)" "unprognostic (2.08e-1)" "unprognostic (1.02e-1)" "unprognostic (8.78e-3)" "unprognostic (2.88e-2)" "unprognostic (5.55e-3)" "unprognostic (9.43e-2)" "unprognostic (1.19e-1)" "unprognostic (3.31e-1)" "prognostic favorable (2.53e-7)" "unprognostic (9.49e-2)" "unprognostic (1.67e-1)" "unprognostic (2.16e-2)" "unprognostic (2.97e-1)" 3.6 5.2 4.1 2.2 4.8 0.8 3.3 4.2 5.2 3.4 3.8 2.4 1.5 4.4 3.9 3.0 7.2 3.7 3.6 5.7 4.9 7.5 2.6 5.0 2.5 3.5 3.7 3.5 2.9 12.8 4.1 2.8 3.7 3.9 2.5 46.3 5.8 3.5 1.6 3.1 1.8 4.2 3.9 3.0 2.8 6.6 3.8 2.3 5.5 2.2 2.2 3.2 2.1 3.7 10.1 5.2 4.9 4.1 11.5 7.6 1.3 6.2 5.5 5.6 6.7 2.2 3.6 5.8 6.1 3.1 8.5 4.6 6.1 6.8 10.4 6.3 3.7 1.5 3.9 2.2 5.4 7.6 3.5 4.1 4.9 7.4 1.7 4.5 6.1 7.0 1.8 1.1 8.1 3.1 4.1 3.2 6.1 4.9 7.5 1.9 5.9 4.0 6.5 2.8 26.0 14.4 5.4 3.4 11.2 3.1 4.3 2.4 5.3 5.2 4.7 4.5 8.7 4.2 5.3 6.4 9.5 4.0 6.4 0.2 0.2 0.1 1.0 0.4 2.1 0.8 0.9 1.1 0.4 1.6 1.6 1.3 0.0 1.8 0.5 0.4 1.7 0.7 4.1 4.8 4.2 5.2 5.7 4.9 3.5 3.7 3.7 3.9 3.8 3.7 3.2 3.2 3.6 31.6 2.2 3.2 3.2 4.8 5.2 12.7 3.2 3.0 2.4 1.5 5.0 9.2 27.1 1.2 0.8 0.6 3.9 3.4 25.7 20.3 4.4 3.7 2.4 2.1 55.0 2.5 2.3 5.1 4.6 2.2 0.0 2.4 4.6 2.9 1.8 5.0 51.5 1.0 6.1 1.3 1.1 5.6 4.1 1.5 1.8 15.0 0.4 8.2 2.1 15.1 27.6 1.7 2.0 4.1 3.7 1.3 0.2 10.1 27.2 57.4 6.6 3.3 4.6 39.6 6.7 4.4 2.0 0.7 2.7 4.6 1.3 2.0 ARL6IP1 "AIP1, ARL6IP, ARMER, KIAA0069, SPG61" ENSG00000170540 "ADP ribosylation factor like GTPase 6 interacting protein 1" Q15041 16 18791669-18801572 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" Apoptosis "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045307 Uncertain Approved "Endoplasmic reticulum" NA Yes "Cluster 44: Non-specific - Transcription" "Cluster 58: Brain - Synaptic function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 12: Non-specific - Cell cycle regulation" "Endoplasmic reticulum" "HPA045307: AB_10961042" "unprognostic (2.42e-1)" "unprognostic (3.47e-2)" "unprognostic (4.07e-3)" "unprognostic (1.12e-1)" "unprognostic (1.54e-1)" "unprognostic (2.60e-3)" "unprognostic (2.58e-2)" "unprognostic (1.76e-2)" "unprognostic (3.88e-2)" "unprognostic (6.83e-2)" "unprognostic (1.91e-3)" "unprognostic (3.33e-2)" "unprognostic (1.13e-2)" "unprognostic (7.09e-2)" "unprognostic (4.60e-2)" "unprognostic (6.32e-3)" "unprognostic (5.36e-3)" 142.0 171.3 206.4 77.7 217.3 209.7 112.9 200.6 282.2 79.2 182.4 140.9 138.8 70.8 122.9 70.0 86.6 131.9 32.1 227.7 209.2 150.1 359.6 79.6 132.6 192.0 197.8 101.6 81.7 180.6 40.7 90.3 200.0 75.9 123.4 316.0 84.3 70.4 23.1 66.1 123.4 69.1 185.0 72.8 125.8 129.9 200.5 158.5 112.5 51.5 113.4 132.5 47.4 197.6 375.3 334.6 417.8 331.6 146.7 93.5 373.2 208.9 196.9 311.0 246.7 205.7 851.1 315.7 388.4 198.0 209.2 388.9 303.7 144.2 359.1 421.2 137.1 227.9 192.5 549.1 116.4 329.9 232.0 78.6 137.7 216.2 224.0 229.1 316.1 180.5 251.0 318.5 607.6 331.4 229.9 238.3 520.0 311.7 109.8 387.9 535.9 266.0 337.8 206.1 255.2 287.5 466.5 279.8 204.5 280.1 576.1 315.9 189.2 204.2 192.9 147.1 384.1 109.5 209.5 383.2 182.8 215.6 405.5 211.4 125.2 84.2 179.4 119.5 167.0 163.2 159.0 199.1 127.4 160.7 137.9 166.4 105.9 179.2 133.3 221.6 281.5 295.0 206.4 217.3 200.6 282.2 227.7 209.2 192.0 197.8 200.0 185.0 200.5 197.6 306.4 67.3 51.0 56.8 170.6 372.6 241.4 170.1 309.6 189.2 256.5 216.8 30.6 361.8 128.7 286.9 131.3 296.7 164.6 269.0 174.1 398.2 74.6 93.3 61.7 188.1 145.9 503.8 70.4 203.1 385.4 150.4 257.9 158.3 135.8 198.0 275.5 457.4 253.9 89.2 94.2 234.6 229.9 275.8 424.6 42.7 84.8 205.8 200.9 39.4 267.3 318.5 142.2 57.3 50.3 271.0 288.5 110.9 107.5 219.4 217.0 189.1 126.6 218.0 92.1 125.6 118.6 193.6 56.6 295.2 326.5 326.6 186.9 53.1 319.7 323.8 ARMS2 "ARMD8, LOC387715" ENSG00000254636 "Age-related maculopathy susceptibility 2" P0C7Q2 10 122454653-122457352 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Age-related macular degeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "testis: 2.9" "Group enriched" "Detected in some" 4 "Early spermatids: 16.9;Late spermatids: 59.1" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA067225 Enhanced NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 31: Spermatids - Spermatogenesis" "HPA067225: AB_2685806" "unprognostic (3.05e-1)" "unprognostic (1.50e-1)" "unprognostic (5.69e-3)" "unprognostic (2.29e-1)" "unprognostic (2.61e-2)" "unprognostic (2.84e-2)" "unprognostic (3.49e-2)" "unprognostic (1.98e-2)" "unprognostic (3.47e-3)" "unprognostic (3.60e-2)" "unprognostic (5.29e-5)" "unprognostic (2.53e-2)" "unprognostic (9.46e-3)" "unprognostic (2.68e-2)" "unprognostic (5.25e-2)" 0.2 0.0 0.3 0.0 0.3 0.0 0.1 0.2 1.3 0.1 0.3 0.2 0.0 0.2 0.0 0.0 0.1 0.1 0.6 0.4 0.4 0.1 0.2 0.0 0.0 0.3 0.4 0.7 0.0 0.0 0.4 1.3 0.4 0.1 0.0 0.5 0.8 0.0 0.0 0.6 0.0 0.1 0.2 0.0 0.1 2.9 0.4 0.0 0.1 0.0 0.0 0.0 0.1 0.8 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.2 1.3 0.4 0.4 0.3 0.4 0.4 0.2 0.4 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 16.9 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.5 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.0 0.0 0.0 59.1 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.1 0.0 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.4 0.5 0.0 0.0 8.6 0.0 0.0 0.0 0.0 ARR3 ARRX ENSG00000120500 "Arrestin 3" P36575 X 70268305-70281840 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Sensory transduction, Vision" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 170 "retina: 392.2" "Cell type enriched" "Detected in some" 8 "Cone photoreceptor cells: 1538.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "Karpas-707: 2.2" "Low region specificity" "Detected in single" "Not detected" "Not detected" HPA063129 Enhanced Approved "Golgi apparatus" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 2: Karpas-707 - Immune response" "Cluster 9: Photoreceptor cells - Phototransduction" "Golgi apparatus" "HPA063129: AB_2732696" "unprognostic (1.48e-2)" "unprognostic (1.65e-1)" "unprognostic (1.70e-2)" "unprognostic (5.37e-2)" "unprognostic (2.82e-1)" "unprognostic (1.37e-2)" "unprognostic (2.06e-2)" "unprognostic (1.22e-1)" "unprognostic (1.35e-2)" "unprognostic (8.09e-2)" "unprognostic (1.33e-1)" "unprognostic (4.02e-3)" "unprognostic (2.77e-7)" "unprognostic (8.64e-2)" "unprognostic (6.53e-2)" "unprognostic (6.06e-2)" "unprognostic (1.43e-1)" 0.2 0.3 0.1 0.5 0.2 0.5 0.0 0.0 0.1 0.0 0.6 0.3 0.6 0.3 0.0 0.2 0.1 0.4 0.4 0.1 0.1 0.1 0.0 0.2 0.9 0.4 0.3 0.3 0.4 0.0 0.0 0.3 0.3 0.3 0.2 392.2 0.3 0.0 0.3 2.3 0.9 0.0 0.1 0.5 0.4 0.2 0.3 0.0 0.4 0.0 0.0 0.2 0.0 0.2 0.1 0.2 1.2 0.8 0.0 0.0 0.7 0.6 0.0 0.0 0.0 0.2 0.4 0.5 0.1 0.0 0.1 0.3 0.0 0.0 0.0 0.5 1.2 0.1 0.4 0.0 0.0 0.2 0.6 0.0 0.0 0.0 0.0 1.3 0.0 0.4 0.1 2.2 0.0 0.2 0.4 0.2 0.3 0.2 0.2 0.4 0.2 0.0 0.0 0.5 0.1 0.3 0.2 0.0 0.0 0.7 0.0 0.1 0.9 0.5 0.7 0.5 0.0 0.5 0.3 0.3 0.5 0.7 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.2 0.0 0.1 0.1 0.1 0.4 0.3 0.3 0.1 0.3 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 46.7 0.0 0.0 0.3 0.0 0.0 0.0 1538.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 23.5 0.2 0.4 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 68.7 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 172.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ARV1 ENSG00000173409 "ARV1 homolog, fatty acid homeostasis modulator" Q9H2C2 1 230978981-231000733 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Spermatocytes: 116.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA035709 Approved Uncertain Vesicles NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" Vesicles "HPA035709: AB_2674744" "unprognostic (2.32e-1)" "unprognostic (4.69e-2)" "prognostic favorable (1.33e-4)" "unprognostic (3.29e-1)" "unprognostic (1.42e-1)" "unprognostic (9.95e-2)" "unprognostic (5.66e-2)" "prognostic favorable (3.27e-5)" "unprognostic (1.37e-1)" "unprognostic (1.12e-2)" "unprognostic (9.57e-2)" "unprognostic (9.82e-2)" "unprognostic (2.31e-1)" "unprognostic (4.82e-1)" "unprognostic (5.63e-2)" "unprognostic (1.39e-1)" "unprognostic (8.12e-3)" 10.6 18.4 23.4 10.2 24.5 13.9 19.0 26.2 32.8 12.2 25.7 24.6 16.4 9.7 22.9 15.7 14.3 16.4 30.1 24.5 25.6 25.2 26.2 15.0 14.8 25.2 24.1 11.2 17.5 33.3 20.1 11.7 25.0 16.2 25.9 29.0 22.0 15.2 21.7 17.8 17.3 13.1 25.7 13.5 17.1 31.3 25.2 15.0 21.9 24.8 15.3 15.2 11.2 27.7 40.8 43.6 20.8 25.1 29.6 26.4 20.1 19.0 34.0 33.5 38.3 16.3 31.4 11.4 22.7 21.3 20.5 32.3 40.6 25.5 39.2 30.4 55.7 36.8 28.9 22.1 30.5 53.6 27.9 28.0 25.8 18.1 20.9 21.9 22.5 34.7 53.7 30.7 22.2 14.3 22.3 16.4 27.1 43.0 27.1 25.2 32.1 33.1 47.1 33.0 21.2 32.6 22.6 26.6 57.9 5.3 46.6 46.6 13.9 13.4 8.7 23.6 45.9 47.4 44.6 28.9 36.8 45.9 36.7 9.1 8.1 8.5 10.0 12.2 13.9 18.1 11.2 12.4 10.1 11.2 13.7 13.0 2.0 12.7 21.2 14.9 15.4 9.0 23.4 24.5 26.2 32.8 24.5 25.6 25.2 24.1 25.0 25.7 25.2 27.7 13.6 16.0 31.7 10.7 12.6 12.9 22.0 75.8 11.4 18.9 14.8 15.6 32.2 21.5 38.9 29.5 2.1 37.9 12.7 15.8 60.7 24.1 52.6 12.7 10.9 12.7 7.7 58.1 20.2 40.8 14.5 14.5 11.7 9.7 17.1 14.4 15.0 17.3 24.9 38.7 25.6 18.5 34.6 13.3 5.5 22.9 9.3 13.5 24.9 8.4 9.8 33.6 7.2 8.5 19.3 21.5 11.5 16.6 14.7 11.6 17.9 32.5 27.3 20.0 0.0 11.4 15.6 116.7 21.0 20.3 15.2 15.6 11.4 22.0 26.4 20.9 ARX "CT121, EIEE1, ISSX, MRX29, MRX32, MRX33, MRX36, MRX38, MRX43, MRX54, MRX76, MRX87, MRXS1, PRTS" ENSG00000004848 "Aristaless related homeobox" Q96QS3 X 25003694-25016420 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Differentiation, Neurogenesis, Transcription, Transcription regulation" "Developmental protein, DNA-binding" "Disease variant, Epilepsy, Lissencephaly, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 17.4;ovary: 78.7;skeletal muscle: 26.7" "Group enriched" "Detected in some" 5 "Enteroendocrine cells: 83.7;Inhibitory neurons: 53.2;Leydig cells: 131.7;Peritubular cells: 70.0;Theca cells: 66.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HAP1: 1.9;PC-3: 3.9;THP-1: 1.7;U-266/70: 8.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" NA NA "Cluster 80: Striated muscle - Unknown function" "Cluster 29: U-266 - Adaptive immune response" "Cluster 52: Non-specific - Transcription" "unprognostic (8.28e-2)" "unprognostic (3.06e-2)" "unprognostic (1.98e-1)" "prognostic unfavorable (3.54e-7)" "unprognostic (9.85e-2)" "unprognostic (7.96e-3)" "unprognostic (1.18e-1)" "unprognostic (2.77e-3)" "unprognostic (1.60e-1)" "unprognostic (1.55e-3)" "unprognostic (1.32e-1)" "unprognostic (1.06e-6)" "unprognostic (6.01e-2)" "unprognostic (1.84e-1)" "unprognostic (1.15e-1)" "unprognostic (1.91e-1)" 0.0 0.1 7.6 0.0 10.1 0.0 0.3 0.0 17.4 0.0 0.0 0.9 3.5 0.0 0.1 0.1 1.1 0.0 0.0 10.1 6.0 0.1 0.0 0.4 0.0 0.0 0.0 78.7 1.4 1.8 0.3 0.0 0.1 0.7 0.9 0.0 0.2 0.0 26.7 0.0 0.7 0.0 0.0 0.2 5.5 7.2 0.4 0.0 0.2 1.9 0.4 0.0 0.2 8.0 0.0 0.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.1 0.0 1.9 0.0 0.0 0.5 0.5 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 3.9 0.4 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.7 0.0 0.0 0.1 0.0 0.0 8.3 0.3 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.6 10.1 0.0 17.4 10.1 6.0 0.0 0.0 0.1 0.0 0.4 8.0 0.0 0.0 0.0 14.0 0.3 0.0 2.5 0.5 0.0 0.0 0.3 0.0 0.5 0.0 2.2 0.0 0.0 0.2 0.1 1.9 0.0 0.0 1.2 0.0 0.0 0.1 83.7 0.0 0.2 0.0 2.4 4.7 4.6 0.0 0.0 0.4 0.0 0.0 0.1 0.0 53.2 3.6 4.1 0.0 0.0 3.6 131.7 0.2 0.0 3.7 0.0 0.0 0.0 3.5 0.6 0.3 0.8 70.0 0.9 1.3 0.1 0.1 11.3 0.0 0.0 1.5 0.3 0.5 0.3 0.0 0.0 0.1 0.3 66.8 1.9 1.6 ASB10 GLC1F ENSG00000146926 "Ankyrin repeat and SOCS box containing 10" Q8WXI3 7 151175698-151187832 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Ubl conjugation pathway" "Disease variant, Glaucoma" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "heart muscle: 26.7;skeletal muscle: 77.9;tongue: 14.2" "Cell type enriched" "Detected in some" 5 "Cardiomyocytes: 12.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA079685 Enhanced NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 37: Myocytes - Muscle contraction" "HPA079685: " "unprognostic (6.72e-3)" "unprognostic (1.96e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 26.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 1.0 0.0 77.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 14.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 12.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ASCL1 "ASH1, bHLHa46, HASH1" ENSG00000139352 "Achaete-scute family bHLH transcription factor 1" P50553 12 102957674-102960513 "Human disease related genes, Predicted intracellular proteins, Transcription factors" "Differentiation, Neurogenesis, Transcription, Transcription regulation" "Activator, Developmental protein, DNA-binding" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 23.0;choroid plexus: 13.7;liver: 11.1;pituitary gland: 30.1" "Group enriched" "Detected in some" 5 "Astrocytes: 17.0;Enteroendocrine cells: 36.4;Oligodendrocyte precursor cells: 42.7" "Group enriched" "Detected in many" 6 "glioma: 21.4;lung cancer: 11.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 21 "SCLC-21H: 53.7;SH-SY5Y: 29.0" "Low region specificity" "Detected in all" "HPA029217, HPA076307" Enhanced Approved Nucleoplasm,Cytosol "Intracellular and membrane" NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 68: Oligodendrocytes - Mixed function" Nucleoplasm Cytosol "HPA029217: AB_10669595, HPA076307: " "unprognostic (7.92e-2)" "unprognostic (4.37e-3)" "unprognostic (4.55e-2)" "unprognostic (5.02e-2)" "unprognostic (3.12e-1)" "unprognostic (1.22e-2)" "unprognostic (1.56e-1)" "unprognostic (2.09e-1)" "unprognostic (4.84e-2)" "unprognostic (1.31e-2)" "unprognostic (1.31e-1)" "unprognostic (7.10e-6)" "unprognostic (3.40e-1)" "unprognostic (2.17e-1)" "unprognostic (3.76e-1)" "unprognostic (5.52e-2)" 0.0 1.1 18.7 0.0 18.3 0.0 0.0 18.9 23.0 0.5 13.7 0.1 0.0 0.2 0.0 0.0 0.8 0.0 0.0 18.2 16.8 0.0 11.1 0.5 0.5 20.1 18.1 0.4 0.2 0.0 30.1 0.0 18.5 0.3 0.1 1.0 0.0 0.0 0.0 0.0 0.0 0.0 19.9 0.0 1.2 0.1 18.7 5.5 0.1 0.0 0.0 0.0 0.3 19.4 0.0 0.0 1.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 53.7 29.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 18.7 18.3 18.9 23.0 18.2 16.8 20.1 18.1 18.5 19.9 18.7 19.4 0.1 0.0 0.0 17.0 0.3 0.0 0.3 0.0 0.0 4.3 0.1 0.5 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.1 0.9 0.0 36.4 0.0 1.7 0.0 0.0 0.2 4.6 0.1 0.0 0.0 0.0 1.8 0.1 5.0 4.1 0.0 6.1 0.0 0.0 0.2 0.0 0.0 0.0 1.0 0.0 2.4 0.0 42.7 0.3 0.2 0.0 0.4 0.1 1.0 0.0 0.0 0.0 0.4 0.0 0.5 0.2 0.1 0.7 0.0 0.0 0.3 0.0 0.0 0.0 0.4 ASPA "ACY2, ASP" ENSG00000108381 Aspartoacylase P45381 17 3472374-3503405 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Hydrolase "Disease variant, Leukodystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 69.0;kidney: 38.2" "Cell type enhanced" "Detected in many" "Leydig cells: 49.7;Melanocytes: 46.2;Oligodendrocytes: 217.0;Peritubular cells: 48.2;Proximal enterocytes: 37.5;Proximal tubular cells: 74.8" "Cancer enhanced" "Detected in some" "renal cancer: 7.7" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "ASC diff: 5.4;ASC TERT1: 4.1;CACO-2: 3.8;HSkMC: 7.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022142, HPA022145" Enhanced Supported Cytosol NA NA "Cluster 11: Basophils - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "HPA022142: AB_1845102, HPA022145: AB_1845103" "unprognostic (4.42e-2)" "unprognostic (4.79e-2)" "unprognostic (2.02e-2)" "unprognostic (2.79e-3)" "unprognostic (4.36e-2)" "unprognostic (5.01e-1)" "unprognostic (1.08e-3)" "unprognostic (3.57e-1)" "unprognostic (4.17e-1)" "unprognostic (3.43e-1)" "unprognostic (5.27e-2)" "unprognostic (6.27e-2)" "unprognostic (1.25e-1)" "unprognostic (7.07e-4)" "unprognostic (2.77e-1)" "unprognostic (4.68e-1)" "unprognostic (1.49e-1)" 13.9 4.3 25.9 1.8 46.4 1.8 4.1 27.6 40.9 7.5 14.2 4.3 11.2 4.5 6.0 4.9 5.5 3.6 2.7 25.8 27.7 38.2 15.0 3.5 1.5 30.4 35.4 2.9 1.0 0.8 0.8 3.5 29.5 4.1 4.9 2.8 1.8 5.0 11.9 5.2 15.6 3.1 24.7 5.4 4.4 6.6 42.4 0.6 2.1 15.0 0.7 6.3 4.3 69.0 0.2 0.1 0.5 0.5 5.4 4.1 0.3 0.2 0.1 0.2 0.1 3.8 0.2 0.6 0.2 0.7 0.3 0.3 0.3 0.1 0.2 2.0 0.1 0.4 0.7 0.2 0.5 0.4 0.4 7.5 0.3 0.4 0.1 0.1 0.1 0.4 0.3 1.1 0.2 0.2 0.2 0.6 0.4 0.2 0.3 0.3 0.3 0.6 0.2 1.1 0.4 0.3 1.1 0.3 0.9 0.4 0.3 0.2 0.4 0.6 0.4 0.4 0.3 0.7 0.4 0.4 0.2 0.4 0.5 1.1 0.1 0.2 0.2 0.1 0.2 0.2 0.2 0.2 0.1 0.3 0.2 0.2 0.7 0.3 0.1 0.2 0.1 0.0 25.9 46.4 27.6 40.9 25.8 27.7 30.4 35.4 29.5 24.7 42.4 69.0 5.1 9.6 1.5 12.1 0.1 5.2 1.5 1.6 6.2 5.5 2.1 0.8 1.3 2.8 1.0 25.8 0.0 0.0 0.0 0.3 7.9 0.2 5.0 0.1 4.1 1.1 2.4 2.7 0.6 0.2 0.1 15.0 2.0 0.2 0.0 0.1 3.9 11.5 0.2 8.4 0.4 0.8 2.0 0.8 1.5 2.5 49.7 0.8 46.2 3.7 0.0 4.1 0.0 1.5 217.0 0.0 2.5 48.2 0.2 0.4 37.5 74.8 0.1 0.5 0.0 8.5 11.6 11.1 0.6 0.7 1.7 0.1 0.4 28.3 1.8 2.7 ATAD1 "FLJ14600, Msp1" ENSG00000138138 "ATPase family AAA domain containing 1" Q8NBU5 10 87751512-87841361 "Disease related genes, Human disease related genes, Predicted membrane proteins" Translocase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 16 "Early spermatids: 987.5;Late spermatids: 1846.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA037569 Uncertain Approved "Nucleoli rim,Mitochondria" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 34: Spermatids - Unknown function" "Nucleoli rim" Mitochondria "HPA037569: AB_10672496" "unprognostic (9.92e-2)" "unprognostic (2.90e-1)" "unprognostic (4.05e-2)" "unprognostic (2.68e-1)" "unprognostic (3.24e-2)" "unprognostic (6.60e-3)" "unprognostic (3.38e-1)" "unprognostic (1.40e-1)" "unprognostic (2.35e-1)" "unprognostic (8.45e-2)" "unprognostic (1.35e-3)" "unprognostic (1.67e-2)" "prognostic favorable (3.98e-6)" "unprognostic (2.35e-1)" "unprognostic (3.29e-1)" "unprognostic (3.45e-2)" "unprognostic (4.22e-2)" 15.7 17.4 9.9 9.0 10.3 4.9 16.3 11.3 12.6 16.0 10.7 18.2 10.9 16.8 13.7 16.2 13.8 10.5 36.1 10.4 11.5 16.7 18.0 14.5 11.8 10.7 11.5 15.9 12.7 28.5 13.4 15.2 11.1 18.7 14.5 28.0 14.9 16.1 37.2 15.1 12.5 13.6 10.0 10.0 13.6 26.4 11.0 13.8 17.4 31.8 12.1 15.5 16.0 10.2 18.8 18.2 20.8 18.2 27.4 29.5 14.4 19.7 33.4 19.6 20.6 14.6 53.8 17.6 15.4 17.3 9.8 31.3 18.9 14.4 21.2 18.6 26.4 15.3 24.0 18.8 30.5 41.7 8.0 23.0 45.4 20.7 42.1 37.2 12.7 14.1 15.9 20.7 22.7 11.2 23.1 22.9 16.4 13.9 10.0 15.8 13.2 19.2 28.9 13.4 14.2 31.5 20.3 12.3 32.0 21.0 29.1 18.0 19.3 16.2 13.9 11.2 24.5 25.4 39.4 22.5 20.8 23.7 11.5 8.4 2.8 4.9 6.3 4.9 10.3 7.2 7.3 8.3 5.4 5.7 9.1 8.6 1.7 8.6 6.9 4.6 7.6 5.7 9.9 10.3 11.3 12.6 10.4 11.5 10.7 11.5 11.1 10.0 11.0 10.2 31.0 54.5 28.0 46.4 41.4 26.8 42.9 46.2 44.3 50.4 29.8 20.8 81.3 27.1 44.9 22.0 35.5 37.7 35.2 33.8 23.5 37.0 987.5 22.3 38.3 21.7 22.8 24.6 69.0 28.0 33.2 35.6 32.6 28.7 29.2 23.1 20.0 28.9 27.3 70.7 73.1 22.9 50.8 18.0 20.1 1846.8 35.8 25.1 32.0 37.5 16.1 59.6 23.7 58.8 52.7 39.0 25.2 47.0 32.3 42.3 20.5 29.5 44.8 54.8 59.2 29.5 43.8 77.2 29.8 34.6 30.1 88.4 40.0 34.8 23.7 54.6 ATCAY BNIP-H ENSG00000167654 "ATCAY kinesin light chain interacting caytaxin" Q86WG3 19 3879864-3928082 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Neurogenesis, Transport" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "brain: 46.6;pituitary gland: 25.6;retina: 17.6" "Cell type enhanced" "Detected in some" "Bipolar cells: 128.5;Excitatory neurons: 67.0;Horizontal cells: 47.1;Inhibitory neurons: 82.2;Oligodendrocyte precursor cells: 94.0" "Cancer enriched" "Detected in some" 8 "glioma: 15.7" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "NTERA-2: 7.3;SCLC-21H: 13.2;SH-SY5Y: 9.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017755 Enhanced NA NA "Cluster 11: Basophils - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 56: Bipolar cells - Visual perception" "HPA017755: AB_2669655" "unprognostic (7.82e-2)" "unprognostic (1.42e-1)" "unprognostic (1.43e-1)" "unprognostic (2.63e-2)" "unprognostic (1.91e-1)" "unprognostic (7.11e-2)" "unprognostic (1.27e-1)" "unprognostic (9.12e-2)" "unprognostic (3.05e-2)" "unprognostic (4.89e-2)" "unprognostic (9.83e-4)" "unprognostic (7.22e-2)" "unprognostic (8.78e-3)" "unprognostic (1.78e-1)" "unprognostic (1.36e-1)" "unprognostic (1.24e-2)" "unprognostic (2.67e-1)" 0.1 6.9 32.1 0.6 34.6 0.3 0.0 0.5 46.6 0.9 0.0 1.1 0.5 0.1 0.1 0.2 0.0 0.2 0.1 29.8 36.1 0.1 0.0 0.1 0.2 17.8 13.8 0.1 0.3 0.0 25.6 0.1 16.7 1.8 0.3 17.6 0.1 3.2 1.2 0.3 0.6 0.2 3.3 0.1 0.4 0.2 17.3 0.0 0.1 0.0 0.0 0.1 0.6 24.6 0.5 0.1 2.7 0.3 0.0 0.0 0.5 0.5 0.0 0.0 0.0 0.1 0.6 0.5 0.2 0.0 1.5 0.4 0.2 0.0 0.0 0.2 0.2 0.8 1.1 0.2 0.0 1.0 1.1 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.5 0.5 0.1 0.2 0.2 0.4 7.3 0.1 0.1 0.2 0.4 0.2 0.1 0.2 13.2 9.3 0.2 0.2 0.1 1.2 0.2 0.2 0.5 0.3 0.6 0.4 0.7 0.3 0.3 0.2 0.3 1.3 0.2 0.6 0.1 0.2 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.2 0.1 0.1 0.6 0.3 0.1 0.1 0.1 0.1 32.1 34.6 0.5 46.6 29.8 36.1 17.8 13.8 16.7 3.3 17.3 24.6 0.2 0.0 3.4 3.3 0.6 0.6 0.8 0.0 0.0 128.5 0.2 0.1 1.9 2.8 0.0 0.0 22.9 0.2 0.1 0.0 0.0 0.0 0.1 0.3 0.9 0.7 0.0 0.0 67.0 0.0 0.2 1.1 0.0 0.8 7.0 0.1 0.7 0.1 0.1 47.1 82.2 0.2 0.0 0.6 2.6 0.0 0.0 0.5 3.6 5.6 0.1 5.4 2.1 94.0 3.9 0.0 0.0 0.4 0.0 0.5 0.0 0.1 0.0 18.7 0.0 1.9 0.7 0.7 1.7 0.0 0.4 0.0 0.6 0.0 0.1 0.4 ATF6 ATF6A ENSG00000118217 "Activating transcription factor 6" P18850 1 161766298-161977574 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors" "Transcription, Transcription regulation, Unfolded protein response" "Activator, DNA-binding" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005935 Approved NA NA 46000000 "Cluster 14: Monocytes - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 41: Macrophages - Immune response" "HPA005935: AB_2667472" "unprognostic (1.31e-1)" "unprognostic (5.15e-3)" "unprognostic (3.18e-2)" "unprognostic (8.43e-3)" "unprognostic (1.59e-1)" "unprognostic (5.58e-3)" "unprognostic (1.24e-1)" "unprognostic (5.32e-2)" "unprognostic (3.37e-2)" "unprognostic (3.24e-1)" "unprognostic (6.09e-3)" "unprognostic (3.38e-1)" "unprognostic (7.55e-2)" "unprognostic (2.03e-1)" "unprognostic (2.43e-1)" "unprognostic (1.56e-2)" "unprognostic (7.57e-3)" 13.6 10.1 7.2 13.9 8.4 12.6 11.5 8.3 7.5 8.4 13.6 9.9 9.9 10.6 18.9 11.0 8.9 11.3 9.4 7.2 9.9 14.6 22.0 11.4 10.6 10.2 9.4 9.0 34.4 18.9 7.1 18.0 10.5 10.7 11.2 16.7 13.3 10.3 8.9 11.2 9.4 12.8 10.0 11.3 11.2 10.1 8.0 8.4 15.1 9.5 11.1 13.7 7.9 11.9 23.3 17.9 15.1 22.4 18.6 17.7 26.7 27.8 25.3 17.7 19.2 11.6 38.2 16.9 39.6 34.6 19.9 34.0 15.1 18.6 17.6 23.2 12.9 15.9 22.6 12.7 40.3 29.7 40.6 18.3 29.0 18.2 53.3 23.8 40.3 22.7 37.9 19.2 19.3 23.0 15.9 17.3 12.2 24.5 23.1 13.7 21.4 39.2 19.3 11.1 9.1 13.8 33.3 19.8 41.0 32.9 24.5 39.2 54.4 23.2 21.9 8.7 31.5 28.0 29.2 20.4 28.2 5.1 29.0 9.7 17.8 12.0 9.2 18.3 9.0 8.7 8.3 7.7 12.8 9.5 9.5 9.7 33.2 7.4 24.4 5.7 9.6 10.6 7.2 8.4 8.3 7.5 7.2 9.9 10.2 9.4 10.5 10.0 8.0 11.9 40.5 102.5 85.1 41.8 31.4 34.8 45.4 28.4 18.2 38.6 38.0 25.4 21.6 25.8 67.0 51.5 50.1 49.2 23.2 30.5 7.9 45.9 13.0 27.1 25.3 49.8 37.1 17.9 79.9 37.6 43.1 46.2 23.9 40.2 54.3 24.0 37.5 53.5 50.3 26.9 69.7 28.2 30.5 59.5 59.4 10.8 23.0 66.6 26.6 103.0 62.0 34.1 21.6 60.3 105.8 35.9 15.6 24.5 53.9 43.3 22.3 18.8 61.7 29.9 6.6 61.3 31.8 43.1 30.5 22.7 47.7 103.0 29.0 22.1 22.9 44.1 ATG5 "APG5, APG5L, ASP, hAPG5" ENSG00000057663 "Autophagy related 5" Q9H1Y0 6 106045423-106325791 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters" "Apoptosis, Autophagy, Host-virus interaction, Immunity" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034432, CAB037309, HPA042973" Approved Approved Centrosome "Intracellular and membrane" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 89: Fibroblasts - ECM organization" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Centrosome "CAB034432: AB_2243288, CAB037309: AB_796188, HPA042973: AB_2678246" "unprognostic (1.21e-3)" "unprognostic (6.53e-3)" "unprognostic (2.68e-3)" "unprognostic (4.14e-1)" "unprognostic (1.13e-1)" "unprognostic (6.35e-3)" "prognostic unfavorable (8.84e-4)" "unprognostic (1.60e-1)" "unprognostic (1.34e-1)" "unprognostic (3.34e-1)" "unprognostic (9.60e-2)" "unprognostic (2.12e-1)" "prognostic unfavorable (8.73e-4)" "unprognostic (1.86e-1)" "unprognostic (2.37e-1)" "unprognostic (2.51e-1)" "unprognostic (6.42e-2)" 12.5 19.2 9.9 6.7 10.2 8.1 15.4 10.5 13.2 15.3 10.7 15.8 12.8 14.9 16.6 12.3 14.7 9.5 9.7 10.3 10.7 14.4 17.7 10.8 8.5 10.0 10.3 14.3 12.1 11.8 7.9 13.2 9.9 15.3 15.2 10.5 11.8 13.1 15.7 8.0 13.1 14.2 9.5 10.6 12.0 8.3 10.2 9.4 17.5 15.2 9.8 13.4 11.9 10.5 14.6 6.0 10.3 14.0 23.2 24.0 10.7 15.4 24.6 22.2 27.2 6.2 8.6 10.2 12.0 23.7 25.0 10.2 15.2 22.2 39.2 4.6 7.3 11.8 6.8 7.8 25.0 14.6 6.0 19.3 24.8 16.1 20.0 29.7 23.9 9.4 17.6 10.0 25.7 6.4 6.0 17.5 11.9 19.4 8.3 6.0 23.7 7.9 24.0 10.3 7.1 6.9 9.4 17.8 14.6 18.6 8.5 27.5 19.8 8.6 4.8 10.1 26.7 4.1 4.2 9.3 31.7 19.6 16.1 4.7 4.8 9.6 2.9 6.1 8.4 5.1 5.6 4.6 5.3 3.3 6.0 5.0 4.1 4.8 8.8 1.9 6.9 3.3 9.9 10.2 10.5 13.2 10.3 10.7 10.0 10.3 9.9 9.5 10.2 10.5 35.8 22.4 18.9 24.2 41.3 26.3 28.5 45.2 25.6 14.8 25.5 26.5 18.1 25.8 36.7 25.8 16.7 47.3 46.5 48.3 29.4 39.6 35.7 33.0 27.4 25.9 19.2 27.0 79.2 44.9 63.8 25.8 42.3 34.5 20.3 20.4 21.8 20.7 38.1 20.2 71.5 38.4 36.7 26.9 32.3 13.7 20.5 33.6 23.2 43.1 44.6 18.3 44.3 43.7 49.1 40.5 59.8 18.0 85.9 40.8 49.2 43.2 30.0 17.9 26.3 23.6 32.1 36.5 39.6 28.5 27.1 66.5 47.3 21.9 36.6 43.0 ATL1 "AD-FSP, FSP1, SPG3, SPG3A" ENSG00000198513 "Atlastin GTPase 1" Q8WXF7 14 50532509-50634017 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Hydrolase "Disease variant, Hereditary spastic paraplegia, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 42.8" "Cell type enhanced" "Detected in many" "Excitatory neurons: 138.6;Inhibitory neurons: 95.5;Oligodendrocyte precursor cells: 81.4;Oligodendrocytes: 136.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "basophil: 22.9" "Lineage enriched" "Detected in many" 5 "granulocytes: 22.9" "Cell line enhanced" "Detected in many" "HDLM-2: 19.8;SCLC-21H: 17.1;SH-SY5Y: 15.4;SiHa: 18.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027550 Enhanced NA NA "Cluster 38: Basophils - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 44: HDLM-2 - Immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA027550: AB_10600983" "unprognostic (2.06e-2)" "unprognostic (7.57e-3)" "unprognostic (1.82e-1)" "unprognostic (7.93e-2)" "unprognostic (2.44e-1)" "unprognostic (1.38e-1)" "unprognostic (2.29e-1)" "unprognostic (1.88e-1)" "unprognostic (7.31e-2)" "unprognostic (1.52e-1)" "unprognostic (1.09e-1)" "unprognostic (6.50e-2)" "unprognostic (1.22e-2)" "unprognostic (3.59e-2)" "unprognostic (2.39e-1)" "unprognostic (4.95e-2)" "unprognostic (1.23e-2)" 4.1 5.6 29.1 3.3 33.2 0.2 11.3 18.8 42.8 5.7 2.2 8.1 3.9 9.0 2.9 5.3 6.5 4.8 2.1 37.1 30.3 4.0 0.3 4.3 1.7 25.2 21.5 10.5 3.7 1.9 7.7 0.5 29.6 8.3 5.6 9.5 13.2 8.6 1.1 9.6 4.9 15.6 24.9 1.1 4.6 8.7 25.0 1.1 2.5 2.2 1.8 6.7 5.3 30.0 1.2 1.1 4.8 4.6 0.3 0.0 3.4 5.7 9.6 6.2 7.4 0.0 4.1 3.7 2.5 0.1 4.5 1.4 8.4 1.1 2.4 19.8 1.8 1.2 0.8 0.3 0.2 0.2 3.1 3.6 1.9 8.6 1.6 0.3 0.4 4.2 0.1 0.5 8.7 0.4 1.2 0.6 4.4 1.4 1.5 0.6 12.1 0.4 1.7 2.5 17.1 15.4 18.9 1.1 0.6 0.0 0.0 2.1 1.3 6.0 4.6 0.0 2.9 0.9 4.7 1.7 3.9 0.2 0.2 22.9 0.1 4.9 2.5 0.0 0.5 3.8 0.9 2.1 1.2 1.1 2.1 4.2 0.3 0.6 0.5 2.8 0.4 2.0 29.1 33.2 18.8 42.8 37.1 30.3 25.2 21.5 29.6 24.9 25.0 30.0 3.0 6.4 2.6 31.6 3.7 5.1 6.2 10.3 6.2 27.8 18.1 16.3 1.9 5.7 6.6 5.5 0.0 0.4 6.7 9.3 0.0 10.6 31.4 4.2 5.4 4.8 7.2 0.4 138.6 13.1 1.1 14.6 5.6 2.3 6.3 1.2 5.0 0.0 1.6 11.8 95.5 1.9 2.0 0.0 3.6 5.7 13.4 5.5 8.8 20.6 1.3 23.0 2.1 81.4 136.7 7.2 6.0 17.0 5.2 3.9 13.2 3.4 14.2 8.6 19.7 4.5 10.8 31.9 5.7 4.1 5.5 0.1 3.8 0.2 3.6 3.3 ATL3 DKFZP564J0863 ENSG00000184743 "Atlastin GTPase 3" Q6DD88 11 63624087-63671921 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Hydrolase "Disease variant, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 6 "Early spermatids: 264.4;Late spermatids: 728.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA065702, HPA076616" Enhanced "Endoplasmic reticulum" NA NA 58000 "Cluster 39: Non-specific - mRNA processing" "Cluster 71: Testis - DNA repair" "Cluster 20: HeLa - Mitochondria" "Cluster 34: Spermatids - Unknown function" "Endoplasmic reticulum" "HPA065702: AB_2685536, HPA076616: AB_2732318" "unprognostic (4.19e-2)" "unprognostic (1.10e-1)" "unprognostic (8.32e-2)" "unprognostic (1.62e-1)" "unprognostic (6.89e-2)" "unprognostic (6.95e-2)" "unprognostic (1.91e-2)" "unprognostic (6.09e-3)" "unprognostic (3.38e-2)" "unprognostic (1.85e-1)" "prognostic unfavorable (1.04e-4)" "unprognostic (4.52e-2)" "unprognostic (1.11e-3)" "unprognostic (7.41e-2)" "unprognostic (2.88e-1)" "unprognostic (1.04e-1)" "unprognostic (7.67e-3)" 30.6 18.1 11.6 17.9 16.6 13.2 22.1 14.9 12.6 23.0 22.0 26.0 9.9 24.3 16.5 24.5 20.1 15.9 11.5 9.8 13.9 12.6 17.7 18.8 12.6 19.8 16.4 16.9 15.4 13.3 6.6 14.9 18.9 16.7 16.6 4.0 15.4 20.4 6.3 25.2 13.7 33.2 16.8 16.9 17.4 36.9 15.5 10.8 20.9 9.6 15.4 27.1 19.4 20.6 44.2 39.4 11.7 28.4 59.2 82.5 0.2 53.2 60.0 51.9 35.0 32.9 69.7 26.3 53.8 93.6 40.0 28.3 21.8 34.8 69.8 40.4 5.8 27.9 41.8 0.2 40.7 53.2 39.2 54.0 55.6 69.1 42.8 34.7 56.3 28.5 30.6 70.2 59.6 46.6 19.2 30.7 14.9 14.1 33.7 40.7 29.3 37.8 41.2 29.7 6.3 17.0 174.3 37.6 50.5 14.5 65.7 19.1 79.1 109.0 51.9 105.3 38.3 19.0 29.6 51.4 57.7 33.6 67.1 7.1 8.3 3.7 8.9 11.4 9.8 5.3 7.4 7.3 8.6 4.2 5.9 8.2 3.5 6.9 13.4 4.3 9.3 7.8 11.6 16.6 14.9 12.6 9.8 13.9 19.8 16.4 18.9 16.8 15.5 20.6 56.7 44.8 27.2 16.6 18.8 43.7 45.7 36.4 30.1 4.8 31.9 18.4 8.5 30.0 29.9 33.1 0.0 6.7 28.5 45.2 1.9 41.2 264.4 23.8 46.4 48.2 10.7 29.5 13.5 50.2 20.1 46.2 19.4 63.8 17.1 20.3 49.6 51.3 37.6 5.0 12.1 21.0 28.5 55.3 43.0 728.4 54.3 35.7 42.7 16.9 49.5 12.6 24.7 16.6 35.6 72.7 24.7 67.4 21.0 55.3 27.7 24.7 21.5 8.5 72.3 35.9 55.2 36.0 29.0 32.9 40.6 4.0 28.2 25.6 19.8 50.9 ATM "ATA, ATC, ATD, ATDC, TEL1, TELO1" ENSG00000149311 "ATM serine/threonine kinase" Q13315 11 108222832-108369102 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, DNA damage" "DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Neurodegeneration, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 210.6;NK-cells: 339.8;Oligodendrocytes: 217.6;Rod photoreceptor cells: 200.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 78.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000102, HPA067142" Supported Supported Nucleoplasm,Vesicles NA NA "Cluster 44: Non-specific - Transcription" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 63: NK-cells & T-cells - Immune response" Nucleoplasm Vesicles "CAB000102: , HPA067142: AB_2685789" "unprognostic (9.77e-2)" "unprognostic (1.47e-1)" "unprognostic (3.04e-1)" "unprognostic (2.36e-1)" "unprognostic (5.70e-2)" "unprognostic (2.86e-2)" "unprognostic (6.32e-3)" "unprognostic (1.05e-1)" "unprognostic (8.19e-2)" "unprognostic (1.63e-1)" "unprognostic (7.68e-2)" "unprognostic (6.16e-2)" "unprognostic (2.17e-3)" "unprognostic (3.10e-1)" "unprognostic (7.87e-2)" "unprognostic (1.21e-1)" "unprognostic (2.81e-1)" 6.2 7.4 8.2 17.5 15.0 16.2 8.5 17.0 12.3 8.7 16.1 6.7 5.2 10.0 9.9 4.0 7.5 8.2 7.0 7.3 11.3 5.8 7.8 7.6 33.7 15.8 13.1 15.8 14.8 9.3 12.1 8.0 17.0 6.3 7.0 20.6 11.4 6.1 4.4 7.5 12.6 6.9 10.3 22.2 8.6 5.2 12.7 18.2 8.8 6.0 25.9 7.1 6.9 28.8 4.3 6.8 14.8 7.6 20.2 29.1 3.1 10.9 13.5 6.4 11.3 7.1 10.3 18.3 14.0 10.2 9.6 7.7 11.6 10.8 9.0 12.3 5.7 15.2 8.7 10.2 10.5 16.4 17.0 18.3 6.3 10.0 21.2 15.2 14.1 16.5 12.4 9.9 14.3 3.4 10.6 18.5 9.8 8.6 7.4 9.7 9.7 24.9 8.1 7.5 9.0 10.5 11.1 4.7 20.6 13.2 9.3 10.1 23.7 15.8 8.4 7.3 9.0 6.2 7.0 78.3 7.0 19.0 18.8 21.3 5.5 4.0 16.5 5.7 11.1 11.6 11.7 12.5 2.6 13.0 21.1 20.4 9.9 9.7 13.3 6.2 6.1 5.3 8.2 15.0 17.0 12.3 7.3 11.3 15.8 13.1 17.0 10.3 12.7 28.8 23.7 38.5 20.8 62.7 146.4 12.6 17.5 21.1 28.5 111.0 19.6 14.2 39.9 12.8 19.5 22.0 210.6 16.9 140.2 4.2 5.9 9.9 19.2 14.4 52.1 25.9 20.4 39.1 70.2 12.3 13.2 39.0 12.8 20.9 13.3 45.9 32.9 23.3 29.1 60.6 82.8 14.9 26.4 96.4 34.0 5.1 39.4 69.2 26.6 178.9 63.2 27.3 339.8 85.5 217.6 7.6 7.6 27.8 96.5 9.1 8.9 11.1 16.0 200.1 26.3 41.4 29.2 31.5 37.4 15.8 12.4 4.2 147.7 52.3 11.5 10.2 ATN1 "B37, D12S755E, DRPLA" ENSG00000111676 "Atrophin 1" P54259 12 6924463-6942321 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Disease variant, Epilepsy, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031619 Enhanced Enhanced Nucleoplasm NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 72: Non-specific - Transcription" "Cluster 44: HDLM-2 - Immune response" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "HPA031619: AB_10601667" "unprognostic (3.86e-3)" "unprognostic (2.07e-1)" "unprognostic (1.80e-3)" "unprognostic (5.82e-2)" "unprognostic (1.37e-1)" "unprognostic (1.95e-1)" "prognostic unfavorable (7.20e-4)" "unprognostic (1.44e-1)" "unprognostic (6.90e-2)" "unprognostic (8.42e-3)" "unprognostic (1.86e-2)" "unprognostic (3.19e-1)" "unprognostic (7.43e-2)" "unprognostic (5.46e-2)" "unprognostic (9.49e-2)" "unprognostic (3.95e-1)" "unprognostic (7.35e-2)" 125.2 148.3 71.7 33.7 60.1 6.9 120.6 94.2 120.0 143.8 14.5 155.4 36.3 146.4 25.5 71.9 148.9 43.2 94.2 66.8 75.7 95.5 42.7 109.0 20.4 81.3 70.6 234.6 79.6 56.7 188.9 43.8 60.0 117.6 21.1 58.8 89.8 59.5 81.9 79.2 82.0 49.4 41.2 74.2 100.4 33.3 71.5 16.3 189.0 34.4 14.0 122.2 108.8 67.4 56.4 72.1 75.9 154.7 69.6 61.7 126.3 65.5 55.4 65.1 45.8 73.6 65.6 15.2 20.4 80.8 54.1 36.8 46.2 63.8 33.3 178.0 46.3 70.6 71.7 35.6 108.3 14.6 103.8 101.8 46.1 82.4 63.6 112.5 64.4 22.4 61.1 29.9 58.2 81.2 31.9 13.5 156.0 26.2 30.1 65.9 40.6 11.2 48.3 78.3 23.4 75.3 66.5 77.2 47.1 73.6 29.5 40.3 85.2 76.7 97.9 61.1 102.2 22.7 8.1 10.7 60.1 18.7 82.3 0.5 0.1 0.7 0.6 0.0 0.5 0.7 0.2 0.3 0.1 0.5 0.3 0.4 0.0 0.1 0.0 0.5 0.3 0.2 71.7 60.1 94.2 120.0 66.8 75.7 81.3 70.6 60.0 41.2 71.5 67.4 66.3 16.0 17.2 76.4 9.1 30.2 13.5 22.9 30.1 26.6 51.5 57.4 16.4 24.3 20.4 29.5 18.8 27.4 11.4 37.4 15.6 20.5 2.3 39.9 61.2 40.7 21.7 4.8 23.8 30.3 15.3 30.9 34.7 51.7 10.1 37.1 39.7 8.0 11.9 25.2 29.7 23.0 8.2 10.9 21.0 3.5 63.6 13.7 21.4 23.4 4.8 17.3 3.1 17.6 18.2 29.9 25.3 52.6 9.5 17.4 24.2 12.1 15.4 23.9 19.7 29.4 39.5 9.7 7.7 22.1 24.9 37.1 10.9 26.2 20.4 17.9 ATOH7 "bHLHa13, Math5" ENSG00000179774 "Atonal bHLH transcription factor 7" Q8N100 10 68230595-68232113 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Differentiation, Neurogenesis, Transcription, Transcription regulation" "Developmental protein, DNA-binding" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 3.0;liver: 3.0" "Cell type enhanced" "Detected in some" "Cone photoreceptor cells: 2.1;Excitatory neurons: 1.7;Hepatocytes: 1.1;Spermatogonia: 1.0" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 8 "SCLC-21H: 7.5" "Region enriched" "Detected in some" 9 "cerebellum: 28.7" "Low region specificity" "Detected in some" HPA027008 Uncertain NA NA "Cluster 15: Liver - Metabolism" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA027008: AB_10600783" "unprognostic (7.17e-2)" "unprognostic (2.81e-1)" "unprognostic (7.66e-2)" "unprognostic (1.86e-2)" "unprognostic (2.20e-3)" "unprognostic (7.40e-2)" "unprognostic (7.76e-2)" "unprognostic (6.16e-2)" "unprognostic (2.46e-1)" "unprognostic (9.28e-4)" "unprognostic (4.96e-3)" "unprognostic (1.17e-1)" "unprognostic (5.06e-4)" "unprognostic (1.72e-1)" "unprognostic (2.52e-2)" "unprognostic (1.36e-1)" "unprognostic (7.18e-2)" 0.1 0.2 1.4 0.0 1.5 0.0 0.1 3.0 2.0 0.1 0.7 0.2 0.2 0.2 0.1 0.0 0.1 0.0 0.0 2.0 1.0 1.2 3.0 0.0 0.0 0.8 0.8 0.1 0.4 0.0 0.2 0.0 0.8 0.1 0.0 0.3 0.0 0.0 0.0 0.1 0.3 0.0 0.8 0.0 0.3 0.2 0.8 0.0 0.0 0.0 0.0 0.1 0.0 1.2 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 7.5 0.2 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 1.5 3.0 2.0 2.0 1.0 0.8 0.8 0.8 0.8 0.8 1.2 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.7 0.2 0.3 0.4 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.9 0.1 0.0 0.0 1.7 0.0 0.0 0.1 0.0 0.4 0.0 0.3 0.0 1.1 0.1 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.7 0.3 0.5 0.0 0.0 0.3 0.0 1.0 0.0 0.0 0.0 0.0 0.4 0.1 0.0 ATP13A2 "CLN12, HSA9947, PARK9" ENSG00000159363 "ATPase cation transporting 13A2" Q9NQ11 1 16985958-17011928 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Transport Translocase "Disease variant, Hereditary spastic paraplegia, Neurodegeneration, Neuronal ceroid lipofuscinosis, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 112.4" "Cell type enhanced" "Detected in many" "Inhibitory neurons: 61.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 6 "plasmacytoid DC: 20.6" "Lineage enriched" "Detected in many" 6 "dendritic cells: 20.6" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB037038, CAB037111, HPA050910, HPA054717" Enhanced NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 22: Non-specific - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB037038: AB_1840715, CAB037111: AB_1840714, HPA050910: AB_2681269, HPA054717: AB_2682583" "unprognostic (3.81e-2)" "unprognostic (1.84e-2)" "unprognostic (5.61e-2)" "unprognostic (2.17e-2)" "unprognostic (1.66e-2)" "unprognostic (2.03e-1)" "prognostic unfavorable (3.33e-7)" "unprognostic (1.04e-1)" "unprognostic (9.71e-3)" "unprognostic (4.51e-1)" "unprognostic (9.85e-3)" "unprognostic (1.85e-1)" "unprognostic (5.75e-2)" "unprognostic (3.25e-2)" "unprognostic (2.62e-1)" "unprognostic (1.10e-1)" "unprognostic (6.84e-3)" 15.3 18.6 49.7 20.2 45.8 11.6 14.3 30.3 81.2 10.6 3.3 15.9 12.7 12.1 6.6 23.6 9.5 9.3 11.6 46.7 66.0 16.6 6.2 17.9 17.7 112.4 60.8 8.7 55.7 12.9 57.0 12.6 110.8 14.3 9.8 22.8 27.4 7.9 17.2 16.5 16.7 8.6 32.0 26.0 19.3 10.3 64.1 9.5 16.7 5.3 10.3 12.9 12.1 44.3 28.3 27.4 14.7 60.8 13.8 12.2 40.8 15.8 15.4 17.1 16.6 48.9 31.4 12.5 65.9 26.9 14.6 43.1 32.1 59.5 6.2 17.2 58.5 43.7 28.0 27.2 17.5 15.6 19.6 10.0 31.6 47.1 36.6 55.0 32.3 32.2 28.2 22.6 70.2 22.2 18.4 8.8 23.2 66.3 20.0 20.0 60.1 50.7 19.0 42.8 40.9 27.4 73.8 87.7 60.2 18.8 29.9 19.6 34.4 18.0 34.5 30.8 33.1 4.8 6.1 14.0 34.6 85.2 30.3 0.0 1.6 0.3 2.6 3.7 2.9 1.3 2.1 2.2 0.4 3.1 1.0 1.5 0.5 2.7 3.6 20.6 1.8 1.4 49.7 45.8 30.3 81.2 46.7 66.0 112.4 60.8 110.8 32.0 64.1 44.3 18.9 0.0 2.2 14.4 8.3 6.5 6.9 5.7 6.2 35.9 16.9 11.3 3.6 7.2 6.8 7.3 35.5 5.8 33.4 44.6 5.9 15.1 1.4 6.7 3.8 14.4 7.7 4.2 53.1 25.1 33.6 6.0 18.8 19.0 8.9 20.5 6.1 3.7 10.4 47.1 61.8 15.0 0.0 17.3 2.8 1.7 5.3 10.1 5.4 11.2 6.1 34.0 8.2 20.1 18.1 57.0 49.0 6.4 5.4 12.3 18.2 5.3 4.3 38.4 0.0 4.6 5.7 13.6 16.4 11.6 5.3 9.3 11.1 4.8 21.7 12.8 ATP1A1 ENSG00000163399 "ATPase Na+/K+ transporting subunit alpha 1" P05023 1 116372668-116410261 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters" "Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport" Translocase "Cancer-related genes, Charcot-Marie-Tooth disease, Epilepsy, FDA approved drug targets, Mental retardation, Neurodegeneration, Neuropathy, Primary hypomagnesemia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 1482.3" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 1879.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SK-MEL-30: 2979.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB018702, CAB069993" Enhanced NA NA 420000 "Cluster 35: T-regs - Unknown function" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 45: Enterocytes - Digestion" "CAB018702: AB_626713, CAB069993: AB_2060979" "unprognostic (6.18e-2)" "unprognostic (2.18e-1)" "unprognostic (6.91e-2)" "unprognostic (1.42e-2)" "unprognostic (6.80e-2)" "unprognostic (2.15e-1)" "prognostic unfavorable (1.42e-4)" "unprognostic (1.80e-1)" "unprognostic (1.21e-2)" "unprognostic (6.32e-2)" "unprognostic (1.61e-2)" "unprognostic (1.65e-1)" "prognostic favorable (8.98e-8)" "unprognostic (4.75e-2)" "unprognostic (1.17e-1)" "unprognostic (3.11e-2)" "prognostic unfavorable (4.01e-4)" 150.9 206.6 115.5 144.1 135.7 104.3 220.2 176.4 264.7 137.6 209.2 580.5 785.5 92.3 304.6 255.9 143.6 361.3 233.1 176.0 133.9 1127.5 132.5 255.7 89.7 140.8 103.5 137.7 661.3 1482.3 160.6 120.0 196.3 176.4 542.6 301.2 721.9 294.1 147.3 316.6 813.9 146.1 117.4 78.1 201.5 140.0 104.1 92.8 744.4 117.7 132.4 149.7 187.4 142.2 399.8 144.8 147.2 74.5 288.8 277.5 750.8 232.9 462.9 281.6 396.6 583.9 278.5 314.2 321.3 279.0 284.4 505.1 293.8 493.7 406.2 116.1 324.2 183.5 249.2 498.4 220.1 465.2 246.1 311.6 808.0 328.4 429.0 395.5 350.8 187.4 306.9 294.2 253.0 793.7 189.6 167.7 346.0 630.5 285.6 179.7 343.4 278.6 1023.2 405.1 143.8 126.7 363.0 679.6 2979.2 358.2 179.1 265.9 311.9 159.4 221.4 415.4 479.5 140.7 118.1 238.0 488.2 263.1 956.1 19.2 36.6 17.2 59.7 56.6 62.8 26.4 66.9 64.2 59.6 15.2 76.5 55.5 4.5 30.8 86.0 30.4 57.6 53.6 115.5 135.7 176.4 264.7 176.0 133.9 140.8 103.5 196.3 117.4 104.1 142.2 199.2 275.7 295.3 26.8 84.6 276.8 336.8 220.5 390.9 101.0 189.2 145.2 74.1 579.0 238.4 770.6 398.2 83.7 89.1 789.9 373.7 625.6 31.2 205.4 54.3 201.6 176.4 89.2 130.5 315.6 160.6 141.6 134.6 372.1 43.8 212.6 144.2 71.2 129.8 102.6 123.9 353.4 463.9 98.8 254.2 19.3 117.8 145.5 208.1 36.5 56.9 556.8 64.9 77.9 60.9 187.6 307.8 100.8 73.2 271.6 1879.9 308.2 171.6 147.7 32.9 109.8 147.4 20.2 35.8 320.7 268.9 67.6 133.3 58.3 498.6 280.6 ATP1A2 "FHM2, MHP2" ENSG00000018625 "ATPase Na+/K+ transporting subunit alpha 2" P50993 1 160115759-160143591 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport" Translocase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 515.9;skeletal muscle: 882.2;tongue: 478.0" "Cell type enhanced" "Detected in some" "Astrocytes: 515.8;Cardiomyocytes: 158.7;Microglial cells: 141.5;Muller glia cells: 73.0;Oligodendrocyte precursor cells: 94.0;Sertoli cells: 85.5" "Cancer enriched" "Detected in many" 18 "glioma: 91.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 51.9;HHSteC: 14.6;RH-30: 16.8;U-87 MG: 10.3" "Low region specificity" "Detected in all" CAB022230 Enhanced NA NA 170000 "Cluster 80: Striated muscle - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 64: Astrocytes - Nervous system maintenance" "CAB022230: " "unprognostic (1.08e-2)" "unprognostic (4.42e-2)" "unprognostic (3.41e-2)" "unprognostic (2.83e-1)" "unprognostic (2.83e-1)" "unprognostic (7.98e-2)" "unprognostic (2.16e-2)" "unprognostic (1.31e-1)" "unprognostic (1.50e-1)" "unprognostic (8.85e-2)" "unprognostic (8.63e-4)" "unprognostic (1.70e-2)" "unprognostic (9.40e-3)" "unprognostic (1.49e-2)" "unprognostic (2.40e-1)" "unprognostic (7.16e-2)" "unprognostic (5.32e-3)" 37.4 4.1 401.5 1.5 480.5 0.0 27.4 419.8 412.8 9.3 164.9 55.8 3.6 5.6 12.5 33.5 14.5 8.0 144.6 337.4 398.5 3.9 1.2 6.4 0.3 429.5 478.8 18.9 1.4 0.3 32.3 3.3 375.3 28.5 8.1 58.5 18.2 28.5 882.2 4.7 15.9 7.8 365.0 1.8 15.7 5.8 515.9 0.6 3.5 478.0 0.5 29.9 9.8 327.7 0.0 0.0 51.9 0.0 5.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.6 0.0 0.1 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.5 0.0 0.0 0.1 4.6 0.0 0.0 0.0 16.8 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 2.0 0.0 4.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 10.3 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 401.5 480.5 419.8 412.8 337.4 398.5 429.5 478.8 375.3 365.0 515.9 327.7 1.4 0.0 0.0 515.8 0.1 0.5 1.6 0.0 0.6 1.3 2.5 0.9 158.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.5 0.2 1.2 11.1 0.0 0.0 5.5 0.0 0.0 4.8 0.0 0.1 0.0 0.5 0.0 0.0 0.1 0.0 2.3 0.0 0.0 0.0 1.3 1.4 28.9 0.5 0.0 141.5 0.5 73.0 0.0 94.0 2.5 0.0 0.0 39.5 0.0 0.8 0.0 0.1 0.1 3.9 85.5 54.9 45.8 0.3 0.2 0.2 0.6 0.1 0.1 5.8 0.0 0.6 ATP1A3 DYT12 ENSG00000105409 "ATPase Na+/K+ transporting subunit alpha 3" P13637 19 41966582-41997497 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport" Translocase "Deafness, Disease variant, Dystonia, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 645.2;heart muscle: 157.7;retina: 292.4" "Cell type enhanced" "Detected in many" "Bipolar cells: 418.1;Cone photoreceptor cells: 171.0;Horizontal cells: 213.7;Inhibitory neurons: 119.1;Late spermatids: 115.6;Rod photoreceptor cells: 291.4" "Cancer enriched" "Detected in many" 5 "glioma: 21.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "Daudi: 57.7;JURKAT: 36.3;Karpas-707: 35.9;REH: 37.1;SCLC-21H: 128.2;SH-SY5Y: 57.7" "CAB033630, HPA045367, HPA056446" Enhanced Approved NA NA 220000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 58: Brain - Synaptic function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 56: Bipolar cells - Visual perception" "CAB033630: AB_781528, HPA045367: AB_2679297, HPA056446: AB_2683136" "unprognostic (1.90e-1)" "unprognostic (8.65e-2)" "unprognostic (4.57e-2)" "unprognostic (8.20e-3)" "unprognostic (8.94e-2)" "unprognostic (2.52e-1)" "unprognostic (3.16e-2)" "unprognostic (7.66e-2)" "unprognostic (8.02e-2)" "prognostic unfavorable (3.44e-4)" "prognostic favorable (6.15e-5)" "unprognostic (4.02e-3)" "prognostic unfavorable (3.02e-6)" "unprognostic (6.84e-2)" "unprognostic (6.48e-2)" "unprognostic (3.45e-1)" "unprognostic (1.27e-1)" 0.2 18.0 115.4 1.4 126.3 0.6 0.1 76.0 645.2 0.0 0.0 3.6 0.9 0.0 0.0 0.3 0.0 0.2 157.7 165.8 275.3 0.1 0.1 0.2 0.9 390.1 61.8 0.1 0.8 1.2 15.4 0.0 320.4 0.2 0.8 292.4 0.8 0.0 0.2 0.3 1.5 0.8 26.3 0.5 1.3 31.5 174.9 2.1 0.2 1.8 0.6 0.1 0.7 200.7 0.0 2.1 0.7 23.1 0.0 0.1 0.1 0.3 0.0 1.6 1.6 0.8 4.3 57.7 2.6 0.4 5.6 0.5 16.2 0.2 0.6 10.7 3.1 5.0 0.2 0.4 0.0 0.0 18.2 0.0 0.2 0.0 0.3 0.3 0.0 36.3 0.0 35.9 0.4 0.8 10.4 0.1 3.0 8.4 14.3 37.1 18.5 1.8 0.0 0.6 128.2 57.7 0.3 4.2 0.1 0.0 3.4 2.6 0.0 3.0 3.2 0.0 1.1 3.7 2.6 12.7 5.5 20.6 0.5 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 115.4 126.3 76.0 645.2 165.8 275.3 390.1 61.8 320.4 26.3 174.9 200.7 0.2 0.0 4.4 9.1 1.1 0.3 0.4 0.0 0.6 418.1 0.3 0.3 19.3 0.0 0.0 0.0 171.0 0.0 3.2 0.8 0.0 0.0 43.7 0.1 0.1 1.4 0.0 0.0 59.1 0.0 0.1 1.0 1.1 0.1 1.3 0.1 0.0 0.0 0.2 213.7 119.1 0.4 0.0 0.0 0.4 115.6 1.8 0.7 0.0 8.4 0.4 40.0 6.2 14.6 11.4 0.0 0.0 0.4 1.0 0.2 0.0 0.1 0.0 291.4 0.0 0.7 0.4 21.2 2.8 0.2 0.3 0.3 3.6 0.4 0.5 0.4 ATP6V1A "ATP6A1, ATP6V1A1, VA68, Vma1, VPP2" ENSG00000114573 "ATPase H+ transporting V1 subunit A" P38606 3 113747033-113812056 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters" "Hydrogen ion transport, Ion transport, Transport" Translocase "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 463.7;Late spermatids: 870.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 79.2" "Group enriched" "Detected in all" 6 "dendritic cells: 38.8;granulocytes: 79.2;monocytes: 37.0" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB006910, HPA035084" Approved Supported Nucleoplasm,Vesicles,Cytosol NA NA 700000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 7: Kidney - Transmembrane transport" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 31: Spermatids - Spermatogenesis" "Vesicles, Cytosol" Nucleoplasm "CAB006910: , HPA035084: AB_2674454" "unprognostic (1.32e-1)" "unprognostic (8.68e-2)" "unprognostic (5.87e-2)" "unprognostic (4.70e-2)" "unprognostic (1.36e-1)" "unprognostic (2.00e-1)" "unprognostic (3.43e-2)" "unprognostic (2.90e-2)" "unprognostic (1.42e-1)" "unprognostic (2.25e-1)" "unprognostic (1.36e-2)" "unprognostic (5.19e-3)" "prognostic favorable (3.82e-12)" "unprognostic (8.82e-2)" "unprognostic (2.46e-3)" "unprognostic (2.43e-1)" "unprognostic (1.52e-2)" 18.1 32.2 40.1 21.6 46.4 16.6 24.5 14.7 53.0 25.3 62.4 22.1 18.5 14.2 15.1 22.7 19.0 20.9 9.0 47.5 58.5 92.7 36.4 24.5 25.1 39.6 23.0 11.3 20.9 60.1 17.1 24.5 39.0 20.9 22.5 58.7 37.5 14.9 7.9 25.0 15.9 15.8 16.9 26.5 22.1 18.1 28.4 22.9 40.8 11.0 28.0 19.6 14.2 21.9 61.7 27.4 33.9 29.7 70.0 30.9 36.0 32.7 49.4 33.7 46.1 52.4 48.3 50.4 75.5 48.0 37.3 39.1 77.5 43.2 43.8 23.1 21.4 44.8 39.3 40.6 57.6 33.2 50.0 42.0 29.1 43.7 30.2 52.0 55.7 25.1 52.0 37.0 50.5 40.5 24.4 14.9 42.8 42.9 34.3 20.8 24.6 57.4 92.5 58.0 65.4 24.1 57.3 38.6 44.9 46.4 58.5 26.6 51.4 31.1 23.1 21.7 19.8 38.4 44.5 46.2 61.1 41.2 35.3 26.8 37.0 12.8 6.3 27.7 5.9 8.2 5.6 6.0 38.8 6.8 5.4 6.2 79.2 9.2 23.9 10.8 8.1 16.7 40.1 46.4 14.7 53.0 47.5 58.5 39.6 23.0 39.0 16.9 28.4 21.9 18.8 28.9 35.0 43.4 24.2 30.3 15.9 30.3 23.9 94.1 27.9 17.1 10.4 31.5 32.9 99.3 41.7 22.0 20.8 38.3 82.2 29.5 463.7 41.7 24.5 26.8 55.8 49.6 119.4 27.5 22.6 17.9 20.9 100.6 10.8 19.4 36.0 74.3 74.3 101.0 107.7 25.4 197.4 104.7 73.3 870.3 18.0 70.9 46.2 34.7 82.8 45.6 11.3 54.3 53.2 27.1 30.5 23.0 23.6 25.6 24.1 80.8 38.3 44.4 6.6 15.3 21.6 28.7 15.7 40.8 47.9 43.9 19.0 25.8 27.2 26.8 ATP7A MNK ENSG00000165240 "ATPase copper transporting alpha" Q04656 X 77910656-78050395 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Copper transport, Ion transport, Transport" Translocase "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Ionocytes: 61.1;Microglial cells: 44.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012887, HPA048107" Approved Supported "Golgi apparatus" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 31: Skin - Epidermis development" "Cluster 2: Karpas-707 - Immune response" "Cluster 59: Non-specific - Transcription" "Golgi apparatus" "HPA012887: AB_1845205, HPA048107: AB_2680266" "unprognostic (3.14e-2)" "unprognostic (3.48e-1)" "unprognostic (4.90e-2)" "unprognostic (1.49e-2)" "unprognostic (1.26e-1)" "unprognostic (1.03e-1)" "unprognostic (7.17e-3)" "unprognostic (2.59e-2)" "unprognostic (3.17e-2)" "unprognostic (2.47e-1)" "unprognostic (2.30e-2)" "unprognostic (1.14e-1)" "prognostic favorable (8.38e-4)" "unprognostic (1.06e-1)" "unprognostic (2.16e-1)" "unprognostic (3.69e-1)" "unprognostic (2.52e-1)" 3.0 4.3 1.2 3.6 1.7 5.9 6.3 2.3 2.1 3.9 1.6 3.4 3.9 3.6 5.0 4.9 3.5 3.6 2.5 1.3 2.1 4.4 2.3 4.5 4.1 2.1 2.1 3.6 2.4 7.3 2.5 4.0 3.8 5.3 3.4 3.0 5.1 3.4 1.8 11.1 3.4 3.2 1.1 4.7 5.5 1.6 1.6 4.7 4.6 2.9 4.6 3.9 2.8 2.9 3.2 8.3 5.4 5.5 5.0 5.3 0.9 4.8 6.6 2.8 5.7 1.0 3.6 4.7 6.9 4.8 3.3 3.8 7.1 3.9 5.2 7.0 4.8 2.4 7.8 0.8 6.3 4.1 4.1 5.6 1.6 5.9 1.8 6.5 7.3 4.7 19.6 17.4 5.2 2.8 4.6 1.4 1.5 11.2 1.7 3.7 9.0 15.8 4.6 8.8 1.6 20.4 11.9 2.8 6.0 3.3 2.2 1.3 9.4 3.7 3.6 5.2 1.9 5.6 10.7 5.2 6.0 2.5 5.7 7.1 1.5 4.5 1.8 1.5 0.9 1.8 1.2 1.2 1.0 1.4 1.4 2.1 8.1 1.2 1.9 1.0 0.4 1.0 1.2 1.7 2.3 2.1 1.3 2.1 2.1 2.1 3.8 1.1 1.6 2.9 14.3 0.0 8.4 15.7 12.6 7.4 5.1 5.8 13.1 6.4 17.3 10.0 5.1 1.5 8.2 9.2 4.2 2.0 15.0 4.5 1.9 5.6 0.5 5.3 9.2 9.7 4.8 22.5 11.1 13.6 2.2 9.4 20.4 8.8 9.5 6.4 14.6 3.6 14.3 1.7 12.5 4.8 61.1 11.7 6.7 1.1 7.2 12.6 19.6 44.0 5.5 4.4 11.3 37.7 35.0 6.2 4.1 9.8 10.5 4.8 4.1 5.5 10.2 4.1 32.9 10.3 8.7 1.8 5.4 20.5 16.6 2.2 13.8 6.7 5.2 6.6 ATP8A2 "ATPIB, ML-1" ENSG00000132932 "ATPase phospholipid transporting 8A2" Q9NTI2 13 25371974-26025851 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins" "Lipid transport, Transport" Translocase "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "brain: 21.6;pituitary gland: 15.2;retina: 17.2" "Group enriched" "Detected in many" 6 "Excitatory neurons: 518.7;Inhibitory neurons: 727.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HMC-1: 19.9;JURKAT: 9.8;MOLT-4: 3.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039926, HPA040033" Supported Supported "Nucleoplasm,Plasma membrane" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 58: Brain - Synaptic function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane" Nucleoplasm "HPA039926: AB_10794205, HPA040033: AB_2676809" "unprognostic (3.79e-2)" "unprognostic (4.28e-2)" "unprognostic (3.32e-2)" "unprognostic (1.95e-4)" "unprognostic (3.57e-2)" "unprognostic (1.89e-1)" "unprognostic (1.31e-2)" "unprognostic (2.97e-3)" "unprognostic (2.77e-1)" "unprognostic (3.66e-1)" "unprognostic (4.96e-4)" "unprognostic (1.24e-1)" "unprognostic (1.18e-2)" "unprognostic (4.20e-5)" "unprognostic (9.10e-2)" "unprognostic (2.95e-1)" "unprognostic (7.22e-2)" 0.1 2.1 5.5 0.3 6.7 0.0 0.6 8.0 21.6 0.2 0.0 0.4 0.3 0.6 1.8 0.0 0.0 0.1 0.1 8.7 19.3 0.3 0.0 0.8 0.6 12.8 4.6 0.2 0.6 0.0 15.2 0.2 12.1 0.1 0.2 17.2 0.1 0.0 0.3 0.1 0.3 0.1 0.2 0.3 0.6 2.9 6.6 1.0 0.1 0.1 0.2 0.2 0.0 6.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.7 1.0 0.0 0.0 0.2 1.5 0.0 0.0 0.0 0.1 0.8 0.0 0.0 0.0 0.0 19.9 0.1 0.0 0.0 0.0 0.6 0.5 9.8 0.0 0.0 1.7 0.1 3.9 0.0 2.0 0.0 0.7 0.0 2.7 0.9 0.2 0.0 3.2 0.0 0.2 0.2 0.1 0.2 0.0 0.4 0.2 0.0 1.0 0.3 0.4 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.5 0.7 0.0 0.0 0.0 0.0 0.2 0.1 5.5 6.7 8.0 21.6 8.7 19.3 12.8 4.6 12.1 0.2 6.6 6.8 0.7 0.0 12.2 9.4 0.8 1.0 0.2 0.3 0.0 21.5 1.5 0.3 2.5 1.5 0.4 0.0 95.9 1.5 0.4 0.0 0.0 0.3 39.0 1.2 23.6 2.6 0.0 0.8 518.7 0.0 0.4 1.7 1.1 0.9 5.1 3.7 0.0 0.0 3.2 21.9 727.7 0.0 0.0 0.0 0.7 30.3 0.9 0.3 0.0 9.4 0.0 7.2 1.0 88.4 24.7 0.0 0.0 1.2 0.1 0.2 0.0 1.3 0.3 91.6 13.1 0.3 0.8 19.8 12.5 0.0 0.4 1.1 1.8 10.1 0.1 0.1 ATXN1 "ATX1, D6S504E, SCA1" ENSG00000124788 "Ataxin 1" P54253 6 16299112-16761491 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Transcription, Transcription regulation" "DNA-binding, Repressor, RNA-binding" "Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 582.5;Inhibitory neurons: 519.0;Oligodendrocyte precursor cells: 318.2;Oligodendrocytes: 466.8" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "cerebral cortex: 14.4" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "U-266/70: 30.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008335, HPA070756" Approved Supported Nucleoplasm,Nucleoli,Cytosol Yes No "Cluster 9: Neutrophils - Innate immune response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 29: U-266 - Adaptive immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "Nucleoli, Cytosol" "HPA008335: AB_1845129, HPA070756: AB_2686306" "unprognostic (1.01e-1)" "unprognostic (4.77e-2)" "unprognostic (1.23e-1)" "unprognostic (5.64e-3)" "unprognostic (4.54e-1)" "unprognostic (1.95e-2)" "unprognostic (7.74e-2)" "unprognostic (4.51e-2)" "unprognostic (4.06e-1)" "unprognostic (1.11e-2)" "unprognostic (3.87e-2)" "unprognostic (2.69e-2)" "unprognostic (1.41e-3)" "unprognostic (1.67e-3)" "unprognostic (2.33e-1)" "unprognostic (1.06e-1)" "unprognostic (3.29e-3)" 4.1 4.0 3.2 5.9 5.3 2.6 4.1 0.0 14.4 8.4 0.0 8.8 3.8 10.9 4.3 5.0 6.2 5.7 5.8 8.4 0.0 4.1 4.7 6.9 4.2 0.0 1.3 5.4 4.8 5.5 6.5 4.9 0.0 7.4 3.8 13.9 4.6 6.2 14.6 5.7 4.8 7.5 0.0 5.7 5.3 3.0 3.9 2.6 6.1 14.8 3.1 6.7 6.6 0.8 4.5 2.6 0.9 0.0 4.4 5.9 5.8 4.8 11.2 2.9 3.3 2.8 2.8 0.2 6.3 9.3 3.7 4.2 0.3 3.0 4.2 2.6 4.7 0.7 4.4 9.0 7.0 4.2 7.0 4.6 5.7 6.1 5.1 11.2 5.9 0.9 0.0 5.3 2.4 2.3 0.3 4.8 0.9 1.4 4.3 0.3 5.8 4.0 4.0 7.6 0.3 2.5 4.4 5.5 9.1 8.4 3.6 7.2 9.1 4.0 6.1 4.8 4.4 30.7 19.2 0.2 2.6 4.3 10.0 0.2 0.5 0.1 0.7 0.4 0.5 0.1 0.5 0.7 0.2 0.0 0.0 0.4 1.3 0.0 0.2 0.1 0.4 0.3 3.2 5.3 0.0 14.4 8.4 0.0 0.0 1.3 0.0 0.0 3.9 0.8 16.0 48.1 25.9 206.3 20.7 91.4 72.2 22.8 48.9 39.8 20.7 14.4 35.9 25.8 26.0 11.0 100.1 0.6 48.4 23.6 7.9 16.7 4.3 80.5 144.4 21.7 1.2 5.7 582.5 8.5 4.0 32.9 22.4 75.8 38.7 67.4 17.2 25.2 22.4 38.7 519.0 16.5 2.0 39.6 79.1 3.3 10.5 41.7 32.0 217.4 42.3 24.1 33.0 318.2 466.8 32.3 16.3 28.2 82.6 56.6 13.9 8.8 33.2 99.9 52.6 19.0 41.6 1.0 6.9 60.9 48.7 0.4 61.5 6.4 7.7 63.8 ATXN10 "E46L, FLJ37990, SCA10" ENSG00000130638 "Ataxin 10" Q9UBB4 22 45671798-45845307 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Ciliopathy, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049531 Approved Supported "Plasma membrane,Cytosol" NA NA 40000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 8: Non-specific - Mitochondria" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Cytosol "Plasma membrane" "HPA049531: AB_2680806" "unprognostic (5.73e-2)" "unprognostic (1.97e-1)" "unprognostic (1.27e-2)" "unprognostic (5.76e-2)" "unprognostic (3.01e-2)" "unprognostic (7.50e-2)" "unprognostic (1.19e-3)" "unprognostic (3.18e-1)" "unprognostic (2.15e-2)" "unprognostic (5.07e-2)" "unprognostic (8.38e-2)" "unprognostic (3.51e-1)" "unprognostic (1.23e-2)" "unprognostic (1.18e-1)" "unprognostic (6.22e-2)" "unprognostic (7.48e-2)" "unprognostic (6.98e-2)" 40.9 59.5 42.2 34.7 46.1 41.9 41.7 35.3 56.8 50.6 26.9 43.7 23.8 50.0 39.0 46.4 56.1 39.6 74.5 50.2 49.6 53.5 64.8 38.2 48.3 37.6 40.1 57.7 57.4 64.9 56.1 48.8 42.1 46.5 36.3 55.1 41.6 40.9 70.6 34.9 27.8 50.2 42.5 34.2 34.4 57.3 46.5 65.9 63.0 59.3 51.6 51.1 45.8 44.5 163.4 84.9 156.2 95.0 70.5 107.6 85.4 181.0 194.3 128.1 139.4 42.9 106.4 169.3 73.2 184.5 66.4 94.4 114.3 121.3 137.7 32.8 119.4 78.9 141.7 79.8 101.9 213.1 56.4 109.0 82.9 66.5 103.1 153.1 96.3 76.2 58.7 89.8 197.2 69.6 116.7 95.6 104.2 90.8 64.0 166.2 60.7 135.9 162.6 152.3 86.9 136.6 113.5 67.2 129.2 119.8 101.4 111.9 87.6 127.5 47.7 46.0 61.4 87.8 57.3 136.8 79.5 88.5 138.5 80.5 99.9 91.8 69.0 121.7 92.3 72.1 68.0 84.3 163.9 72.6 74.4 71.9 4.7 86.2 138.5 58.1 70.8 120.2 42.2 46.1 35.3 56.8 50.2 49.6 37.6 40.1 42.1 42.5 46.5 44.5 38.1 35.3 33.3 127.3 50.6 50.5 124.2 156.0 68.9 66.3 45.4 50.0 94.2 65.8 76.7 58.8 20.9 101.9 32.3 17.1 68.4 91.1 69.2 53.7 53.7 44.4 60.3 63.1 148.6 69.5 106.3 70.7 34.1 49.8 39.9 93.5 36.4 54.9 72.2 70.7 157.9 35.4 79.3 49.0 36.5 40.6 57.5 48.3 24.9 103.0 67.9 79.3 27.8 186.5 168.1 51.6 24.0 75.6 53.3 115.2 18.6 66.9 67.6 53.6 46.0 45.1 54.6 133.8 108.3 65.1 41.5 52.3 47.8 102.2 44.5 102.0 ATXN2 "ATX2, SCA2, TNRC13" ENSG00000204842 "Ataxin 2" Q99700 12 111443485-111599676 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Amyotrophic lateral sclerosis, Neurodegeneration, Parkinsonism, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 209.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018295, HPA020339, HPA021146" Enhanced Enhanced Cytosol NA NA 9600 "Cluster 27: Non-specific - Gene expression" "Cluster 35: Non-specific - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" Cytosol "HPA018295: AB_1845130, HPA020339: AB_1845131, HPA021146: AB_1845132" "unprognostic (3.08e-1)" "unprognostic (1.52e-1)" "unprognostic (1.29e-1)" "unprognostic (7.82e-2)" "unprognostic (1.55e-1)" "unprognostic (3.53e-1)" "prognostic unfavorable (2.66e-4)" "unprognostic (2.34e-1)" "unprognostic (2.77e-2)" "unprognostic (1.09e-1)" "unprognostic (1.30e-1)" "unprognostic (4.58e-1)" "unprognostic (5.28e-2)" "unprognostic (1.81e-1)" "unprognostic (2.58e-1)" "unprognostic (3.00e-1)" "unprognostic (3.40e-2)" 19.6 23.5 20.5 11.2 21.9 8.0 17.5 22.8 30.3 21.6 20.8 22.8 11.2 21.7 13.9 14.2 20.4 12.0 22.2 20.5 29.9 17.5 20.1 19.7 9.5 25.2 26.0 25.9 13.8 18.6 21.9 16.3 24.5 19.4 11.6 15.7 14.5 15.6 25.8 15.6 14.9 18.3 18.6 14.1 16.3 23.2 22.7 12.8 17.1 20.8 8.9 19.6 18.3 25.8 31.0 38.0 30.3 38.2 35.9 29.0 29.4 35.8 25.9 28.8 23.4 25.2 25.7 25.8 14.2 47.7 23.8 25.5 45.0 18.2 36.0 23.3 33.9 38.2 22.8 42.4 49.7 27.1 21.4 32.4 20.1 38.0 42.6 48.0 27.8 20.2 46.8 13.1 37.2 24.7 23.2 24.2 30.1 19.4 24.6 21.8 18.6 19.2 30.1 34.5 28.7 25.2 38.5 49.3 24.7 29.1 30.9 16.5 34.9 36.9 21.6 30.4 20.6 23.4 30.0 22.5 19.0 20.9 23.5 4.5 3.6 5.8 3.9 3.4 5.2 5.1 4.9 5.3 5.0 2.7 4.1 3.6 3.5 5.6 6.4 2.7 2.2 2.8 20.5 21.9 22.8 30.3 20.5 29.9 25.2 26.0 24.5 18.6 22.7 25.8 43.0 80.1 72.6 175.3 26.7 35.3 34.3 18.4 35.9 101.0 33.6 26.3 36.6 30.0 36.6 36.8 135.5 32.5 28.9 25.6 3.9 26.0 11.1 87.2 72.2 43.9 41.4 34.9 146.7 25.3 25.4 40.0 23.9 50.3 23.5 67.2 63.5 38.1 24.5 65.6 171.8 26.7 24.4 35.9 35.9 11.9 65.6 30.6 32.0 106.8 35.1 32.6 48.4 128.7 209.6 32.6 16.0 47.4 24.2 43.0 22.7 16.9 56.0 90.4 32.9 41.5 46.6 78.0 70.7 25.7 35.2 46.9 27.4 68.7 31.5 42.2 ATXN3 "ATX3, JOS, MJD, SCA3" ENSG00000066427 "Ataxin 3" P54252 14 92044496-92106621 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB021976, HPA024123, HPA069338" Uncertain Approved "Nucleoplasm,Nucleoli,Plasma membrane" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 28: BEWO - Transcription regulation" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Nucleoli" "Plasma membrane" "CAB021976: , HPA024123: AB_1845133, HPA069338: AB_2686124" "unprognostic (1.06e-2)" "unprognostic (2.93e-1)" "unprognostic (1.22e-1)" "unprognostic (3.67e-2)" "unprognostic (5.76e-2)" "unprognostic (1.57e-1)" "unprognostic (1.42e-1)" "unprognostic (9.85e-3)" "unprognostic (1.69e-1)" "unprognostic (6.75e-2)" "unprognostic (1.04e-2)" "unprognostic (3.06e-2)" "unprognostic (2.03e-2)" "unprognostic (8.94e-3)" "unprognostic (4.22e-1)" "unprognostic (1.64e-1)" "unprognostic (1.11e-1)" 9.0 5.9 3.8 5.7 4.2 9.9 6.8 4.9 5.0 7.5 3.3 7.3 3.7 6.4 4.3 10.3 6.0 6.5 5.3 3.6 5.0 5.6 9.6 6.8 7.7 6.2 5.7 7.1 4.5 6.4 4.0 7.0 6.2 6.0 6.8 3.9 5.8 5.5 3.3 12.9 4.8 8.6 4.3 5.6 5.2 9.3 4.3 8.0 5.9 5.9 9.8 9.0 8.0 4.9 8.6 16.7 14.6 13.6 20.9 20.1 28.4 9.7 15.4 11.9 16.5 12.3 23.2 17.6 18.5 15.8 14.1 14.6 11.6 21.0 26.3 20.0 3.5 7.4 8.0 18.2 17.3 13.5 12.6 16.5 18.1 20.9 21.8 15.9 18.7 19.4 10.1 12.5 18.2 33.1 14.0 11.9 10.4 28.5 13.6 11.0 27.0 9.9 15.3 19.4 5.3 8.8 23.1 9.5 13.3 19.6 18.1 9.1 10.0 11.7 17.0 7.5 5.2 10.8 19.8 16.2 8.3 12.9 6.9 13.5 14.3 10.8 6.1 16.5 7.4 7.7 7.0 6.9 16.2 10.6 7.8 8.8 12.2 8.7 23.0 9.3 8.1 6.3 3.8 4.2 4.9 5.0 3.6 5.0 6.2 5.7 6.2 4.3 4.3 4.9 55.0 16.0 12.4 33.6 27.6 25.4 28.6 29.8 19.4 35.4 16.9 18.4 19.3 15.7 20.0 42.3 50.1 20.3 31.5 13.8 15.6 25.8 19.8 20.3 34.9 53.0 16.1 30.3 36.1 17.3 29.8 34.6 18.3 22.5 24.6 25.9 49.6 21.1 22.4 26.9 28.6 16.4 12.2 35.1 27.2 26.8 67.7 30.0 23.2 28.1 48.0 20.4 29.9 39.2 51.5 19.6 16.1 65.1 20.1 31.9 16.6 17.7 16.0 46.7 46.0 51.9 38.2 39.1 57.2 21.6 30.3 25.3 28.8 24.8 18.9 28.2 ATXN7 "ADCAII, OPCA3, SCA7, SGF73" ENSG00000163635 "Ataxin 7" O15265 3 63863155-64003462 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 102.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "basophil: 15.8" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA034989 Approved Nucleoplasm,Cytosol NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 2: Karpas-707 - Immune response" "Cluster 63: NK-cells & T-cells - Immune response" "Nucleoplasm, Cytosol" "HPA034989: AB_10602596" "unprognostic (1.51e-2)" "unprognostic (2.44e-1)" "unprognostic (5.98e-2)" "unprognostic (2.18e-1)" "unprognostic (1.92e-1)" "prognostic favorable (1.22e-4)" "unprognostic (9.65e-2)" "unprognostic (2.76e-2)" "unprognostic (2.46e-1)" "unprognostic (2.12e-1)" "unprognostic (7.82e-2)" "unprognostic (9.77e-3)" "unprognostic (2.56e-1)" "unprognostic (8.04e-2)" "unprognostic (1.74e-1)" "unprognostic (9.19e-2)" "unprognostic (3.45e-2)" 7.5 6.3 4.5 11.4 4.1 24.4 7.1 4.9 4.4 7.4 0.2 6.9 8.0 8.6 4.7 8.7 6.3 9.6 5.8 3.1 3.7 7.1 8.4 9.0 12.7 3.4 3.3 8.0 21.0 10.9 2.3 8.3 2.7 6.7 8.8 16.3 7.8 5.2 7.1 9.3 9.2 7.9 0.7 10.6 8.4 15.0 3.1 16.5 7.5 8.7 11.7 7.4 4.4 3.2 8.4 5.7 8.1 7.2 8.5 11.3 9.5 6.5 9.0 11.1 10.5 8.9 8.7 12.5 3.1 9.0 12.5 6.5 9.6 9.1 11.9 22.8 4.9 16.1 10.7 4.2 6.4 8.5 17.7 7.9 9.0 15.7 17.7 9.0 8.4 13.3 6.3 26.2 7.7 25.8 12.7 6.8 5.5 5.7 3.0 9.1 7.1 10.1 6.1 11.0 3.1 5.6 13.2 9.4 10.8 6.4 5.1 12.2 11.9 11.4 12.0 12.7 12.9 12.9 13.2 10.3 10.3 11.6 9.4 15.8 1.1 2.1 3.7 1.0 3.3 1.0 6.2 4.0 0.8 2.4 6.2 4.1 4.5 3.5 0.7 1.5 6.2 1.3 4.5 4.1 4.9 4.4 3.1 3.7 3.4 3.3 2.7 0.7 3.1 3.2 2.4 9.6 9.1 34.6 17.0 43.6 24.9 17.6 29.6 73.2 3.4 1.7 10.5 35.8 17.9 5.5 102.2 14.1 21.5 38.3 0.0 2.8 17.1 3.3 1.5 16.1 26.4 29.5 81.2 4.2 13.6 16.6 18.8 3.5 14.7 1.2 26.7 22.8 14.2 25.2 67.0 19.7 24.4 34.6 30.3 9.5 12.8 20.1 12.4 64.6 33.5 24.5 54.6 60.3 46.7 2.5 28.5 13.2 14.8 26.1 28.1 0.7 27.4 70.8 0.0 39.2 15.6 14.8 15.6 25.6 46.2 61.2 41.5 1.6 20.1 38.6 B2M ENSG00000166710 Beta-2-microglobulin P61769 15 44711487-44718851 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins, Transporters" Immunity "Amyloidosis, Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "monocytes: 31919.3;NK-cells: 24726.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002572, HPA006361" Enhanced Enhanced "Golgi apparatus,Plasma membrane,Cytosol" "Secreted to blood" NA NA 1790000000 2100000000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 64: Macrophages - Immune response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 3: Monocytes - Immune response regulation" "Golgi apparatus, Plasma membrane" Cytosol "CAB002572: AB_563434, HPA006361: AB_1078278" "unprognostic (9.45e-2)" "unprognostic (5.63e-2)" "unprognostic (3.02e-1)" "unprognostic (8.14e-2)" "unprognostic (1.18e-1)" "unprognostic (4.82e-2)" "unprognostic (1.81e-2)" "unprognostic (1.25e-1)" "unprognostic (2.69e-2)" "unprognostic (1.12e-1)" "unprognostic (2.44e-3)" "unprognostic (2.02e-2)" "unprognostic (4.77e-2)" "unprognostic (2.39e-1)" "unprognostic (5.25e-2)" "unprognostic (1.97e-2)" "unprognostic (2.17e-2)" 3160.2 3214.7 697.6 5686.5 705.1 7839.2 2606.9 711.8 1145.0 2539.9 789.6 5139.0 5180.7 2192.2 1735.6 2283.9 1648.3 4948.8 2327.2 651.0 769.9 2462.6 6206.2 6159.2 9311.8 889.5 763.2 1945.7 1310.9 1940.5 318.4 3502.0 815.3 2345.0 5593.5 139.3 5657.1 1784.5 931.7 3015.6 5693.3 2545.3 838.3 7896.1 4878.2 615.6 771.9 4217.4 2340.8 2026.5 5333.4 5753.1 549.4 909.5 1735.4 378.9 226.0 633.6 4348.7 4719.4 1662.5 2045.5 4961.9 3609.7 6561.4 425.3 5417.9 554.8 2567.9 1948.8 2410.2 2537.0 497.2 878.7 1226.2 4762.2 435.9 2956.9 2263.6 600.3 3609.3 2074.5 3328.6 2735.9 609.8 1075.7 1044.4 2442.6 1884.1 965.4 611.9 3649.1 2195.5 476.9 1518.4 3213.8 206.5 629.8 1014.3 2240.2 1926.6 4789.2 2425.5 3486.4 254.1 179.1 1288.4 1571.2 1338.5 394.3 655.3 6180.6 2548.7 4531.4 676.5 5389.2 2193.3 4771.7 7118.6 1683.1 5384.6 3783.6 2567.3 48105.4 18117.1 33178.9 20639.1 17775.0 20836.8 15768.0 23783.0 22245.1 9978.8 11988.4 17122.9 22791.8 50453.6 18779.6 19034.9 12052.6 29659.1 56957.2 697.6 705.1 711.8 1145.0 651.0 769.9 889.5 763.2 815.3 838.3 771.9 909.5 12048.3 3387.8 3505.1 28.7 8472.8 7843.7 3197.1 8420.8 1628.8 33.3 2399.5 2015.2 1068.8 3593.1 5347.4 2100.3 27.1 1354.6 14028.8 8753.6 1038.9 13898.6 43.1 2073.7 2414.0 8385.6 2266.0 2087.2 7.3 9034.5 4397.5 3691.1 1981.7 2282.2 3029.5 1270.6 6835.7 3832.6 11985.7 5.0 22.0 5982.6 8701.4 12536.8 14507.0 158.8 3018.0 10687.9 6744.8 368.2 31919.3 322.0 24726.3 95.0 129.2 10115.7 7085.6 1688.8 11026.6 5300.4 18327.7 3122.5 8367.9 52.5 4016.7 2055.2 4107.1 64.2 72.1 1541.4 8619.8 804.8 14266.2 3229.8 3063.4 8248.6 B4GALNT1 "beta1-4GalNAc-T, GALGT, SPG26" ENSG00000135454 "Beta-1,4-N-acetyl-galactosaminyltransferase 1" Q00973 12 57623409-57633239 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Lipid metabolism, Sphingolipid metabolism" "Glycosyltransferase, Transferase" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "brain: 61.1" "Cell type enhanced" "Detected in some" "Bipolar cells: 10.0;Excitatory neurons: 22.0;Horizontal cells: 21.9;Inhibitory neurons: 13.4;Smooth muscle cells: 7.5" "Cancer enriched" "Detected in many" 6 "glioma: 10.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HDLM-2: 67.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008968 Enhanced "Intracellular and membrane" NA NA 35000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 10: Brain - Neuronal signaling" "Cluster 9: U-2 OS - Unknown function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA008968: AB_1078253" "unprognostic (3.18e-1)" "unprognostic (8.34e-2)" "unprognostic (2.05e-2)" "unprognostic (3.33e-3)" "unprognostic (2.54e-1)" "unprognostic (2.70e-3)" "unprognostic (3.73e-5)" "unprognostic (1.26e-2)" "unprognostic (1.72e-1)" "unprognostic (2.66e-1)" "unprognostic (2.00e-1)" "unprognostic (1.67e-1)" "prognostic unfavorable (3.18e-14)" "unprognostic (2.52e-2)" "unprognostic (1.81e-1)" "unprognostic (1.44e-2)" "unprognostic (4.92e-4)" 1.9 1.1 26.9 1.9 29.7 0.0 0.7 29.3 61.1 1.3 0.6 2.7 0.5 2.1 2.7 0.7 0.7 1.1 3.3 34.9 21.9 0.8 0.4 0.6 0.6 16.7 11.8 0.3 0.3 0.3 1.7 0.4 20.5 2.6 1.2 4.2 1.8 5.0 9.5 0.6 1.2 2.5 8.1 0.6 0.9 0.7 19.1 0.3 1.2 7.2 1.0 1.2 1.6 29.9 7.5 38.2 18.2 38.7 0.3 0.1 0.4 3.0 11.3 19.0 17.5 2.8 21.9 3.0 47.9 13.2 35.9 3.3 15.3 2.1 5.2 67.4 2.6 1.8 10.1 9.9 0.4 3.1 4.1 0.1 0.9 11.0 0.5 6.7 0.2 11.4 8.7 34.8 2.4 13.5 2.5 0.1 13.0 0.9 7.7 0.1 27.1 8.0 0.1 0.1 34.9 12.3 3.1 1.1 0.4 0.9 7.0 3.3 0.0 22.8 28.1 24.0 26.1 37.0 34.0 2.6 28.9 2.3 45.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 26.9 29.7 29.3 61.1 34.9 21.9 16.7 11.8 20.5 8.1 19.1 29.9 0.8 0.0 0.0 2.6 0.0 0.4 0.0 0.0 0.0 10.0 0.0 0.5 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.2 1.0 0.8 0.0 0.0 22.0 0.2 0.2 1.0 0.0 0.0 0.0 0.0 0.4 0.1 0.1 21.9 13.4 0.0 0.0 0.0 0.3 0.7 2.8 0.1 3.6 2.8 2.6 0.7 0.0 4.5 2.7 0.5 0.0 3.0 0.0 0.1 0.0 0.2 0.0 2.6 6.6 0.6 7.5 1.6 4.0 0.0 0.0 0.0 0.4 0.2 0.0 0.1 BBS2 BBS ENSG00000125124 "Bardet-Biedl syndrome 2" Q9BXC9 16 56466836-56520087 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cilium biogenesis/degradation, Protein transport, Sensory transduction, Transport, Vision" "Bardet-Biedl syndrome, Ciliopathy, Disease variant, Mental retardation, Obesity, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 144.3;Oligodendrocytes: 97.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041315 Approved NA NA "Cluster 44: Non-specific - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 64: Astrocytes - Nervous system maintenance" "HPA041315: AB_10960892" "unprognostic (1.43e-1)" "unprognostic (3.13e-3)" "unprognostic (2.44e-2)" "unprognostic (1.03e-1)" "unprognostic (7.58e-2)" "unprognostic (1.51e-2)" "unprognostic (4.22e-2)" "unprognostic (2.79e-2)" "unprognostic (2.11e-1)" "unprognostic (3.29e-2)" "unprognostic (3.76e-3)" "unprognostic (2.68e-1)" "prognostic favorable (2.83e-6)" "unprognostic (2.16e-1)" "unprognostic (1.61e-1)" "unprognostic (2.95e-1)" "unprognostic (2.95e-2)" 20.3 78.3 90.1 9.3 102.5 6.0 29.5 93.2 117.7 31.1 80.7 23.6 13.5 25.9 47.1 23.2 32.7 21.6 32.8 87.5 89.4 41.7 13.2 20.2 18.4 94.4 90.4 40.7 15.7 53.7 38.1 16.1 96.2 26.9 16.9 86.5 20.0 27.0 41.5 36.4 17.7 24.0 89.4 21.0 17.2 28.6 91.5 18.3 28.1 50.8 16.2 21.1 29.7 107.9 22.3 19.7 29.6 29.9 47.1 56.9 17.4 10.7 40.9 23.1 29.8 11.0 18.0 22.1 17.6 24.3 19.0 25.3 11.7 36.4 36.0 4.9 26.3 10.4 19.4 28.1 30.7 12.1 11.4 35.4 26.7 18.3 16.8 49.0 50.0 16.7 4.7 2.7 28.9 15.2 16.8 14.1 7.9 14.9 32.7 12.9 8.3 25.7 36.2 18.1 20.7 15.5 51.9 20.2 27.8 23.7 17.2 14.3 43.3 18.3 11.6 8.3 5.7 10.4 8.7 17.1 31.6 10.5 13.7 9.9 9.6 24.5 15.6 13.6 15.8 11.4 18.7 20.6 11.8 12.4 24.4 23.2 2.7 7.4 22.4 3.4 16.4 14.0 90.1 102.5 93.2 117.7 87.5 89.4 94.4 90.4 96.2 89.4 91.5 107.9 11.5 0.0 24.3 144.3 9.6 11.2 15.6 19.1 23.9 21.5 10.7 11.3 24.4 5.7 18.7 11.0 25.0 14.3 6.6 8.7 7.9 7.1 21.1 22.4 10.7 12.3 6.7 4.6 41.0 5.8 7.3 18.6 7.7 16.9 10.1 27.0 12.1 6.9 11.2 20.2 39.6 10.3 24.4 11.3 6.3 19.7 18.0 8.9 10.6 26.2 9.0 26.6 7.2 71.4 97.8 6.0 10.4 20.7 4.1 4.7 11.5 20.0 56.1 34.6 19.7 16.7 12.0 18.4 20.7 13.1 14.1 7.5 10.5 59.2 11.1 10.0 BDNF ENSG00000176697 "Brain derived neurotrophic factor" P23560 11 27654893-27722058 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" "Growth factor" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 8.2" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 38.5;Bipolar cells: 13.8;Cardiomyocytes: 9.1;Excitatory neurons: 22.3;Smooth muscle cells: 25.8;Theca cells: 9.3" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ: 36.6;BJ hTERT+ SV40 Large T+: 28.0;BJ hTERT+ SV40 Large T+ RasG12V: 20.9;HBF TERT88: 26.5;U-138 MG: 37.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB009564, HPA031440, HPA056104" Enhanced Supported "Nuclear speckles,Mitochondria" "Secreted to blood" NA Yes 16000000 24000 "Cluster 10: Brain - Neuronal signaling" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 10: Non-specific - Unknown function" "Nuclear speckles, Mitochondria" "CAB009564: AB_2064213, HPA031440: AB_2673883, HPA056104: AB_2683038" "unprognostic (1.25e-2)" "unprognostic (2.84e-1)" "unprognostic (4.35e-2)" "unprognostic (2.54e-2)" "unprognostic (1.01e-2)" "unprognostic (6.82e-2)" "unprognostic (2.39e-2)" "unprognostic (2.21e-1)" "unprognostic (3.20e-1)" "unprognostic (1.78e-1)" "unprognostic (1.22e-2)" "unprognostic (2.65e-1)" "unprognostic (3.22e-2)" "unprognostic (3.88e-2)" "unprognostic (5.88e-2)" "unprognostic (1.40e-1)" "unprognostic (2.84e-3)" 0.4 0.5 1.9 0.2 2.4 0.2 0.2 3.3 5.3 0.6 0.1 0.4 0.3 0.2 3.3 0.6 0.1 0.7 3.6 8.2 1.9 0.6 0.1 2.0 0.1 3.3 2.1 0.5 0.4 0.0 1.2 1.6 2.5 2.0 0.1 0.7 0.3 1.8 0.4 0.9 0.1 0.1 0.4 0.1 0.3 0.6 1.6 0.3 1.0 0.0 0.1 2.1 0.6 0.8 2.9 12.2 0.3 0.0 3.7 2.2 0.0 36.6 7.9 28.0 20.9 0.1 4.0 0.0 3.7 11.8 0.5 1.4 0.1 0.2 26.5 0.2 0.1 0.0 3.5 0.0 17.4 0.2 0.2 9.2 4.2 6.8 3.7 18.1 1.3 0.1 0.0 0.1 4.8 0.0 0.0 0.0 4.0 0.1 2.9 0.0 2.0 0.0 4.5 0.0 0.2 1.1 7.8 0.1 0.1 1.7 0.2 0.0 11.0 37.6 6.9 14.4 9.2 0.5 0.1 0.0 14.1 1.3 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 2.4 3.3 5.3 8.2 1.9 3.3 2.1 2.5 0.4 1.6 0.8 0.2 38.5 0.5 1.6 0.0 0.6 0.4 0.5 1.8 13.8 0.5 0.9 9.1 0.0 0.4 1.8 4.2 0.4 0.0 0.1 0.0 0.8 1.8 0.3 0.3 0.2 0.0 0.0 22.3 0.0 0.5 6.1 0.0 0.1 1.3 1.9 0.0 0.0 0.3 0.0 0.6 0.0 0.0 0.0 0.4 1.5 0.3 0.9 1.8 0.0 0.0 0.2 0.0 2.0 2.2 0.2 0.0 0.0 0.0 0.8 0.0 1.5 0.1 1.8 0.0 1.8 25.8 3.7 0.8 2.3 0.0 0.7 0.0 9.3 0.1 0.1 BDP1 "HSA238520, KIAA1241, KIAA1689, TAF3B1, TFC5, TFIIIB150, TFIIIB90, TFNR" ENSG00000145734 "B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB" A6H8Y1 5 71455651-71567820 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Transcription, Transcription regulation" Activator "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "TIME: 16.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA064166, HPA077984" Enhanced Nucleoplasm NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 8: Non-specific - Mitochondria" "Cluster 17: WM-115 - Nervous system development" "Cluster 52: Non-specific - Transcription" Nucleoplasm "HPA064166: , HPA077984: " "unprognostic (4.96e-2)" "unprognostic (2.19e-1)" "unprognostic (6.65e-2)" "unprognostic (3.01e-1)" "unprognostic (3.47e-2)" "unprognostic (1.44e-2)" "unprognostic (7.72e-2)" "unprognostic (2.02e-1)" "unprognostic (9.59e-3)" "unprognostic (8.20e-2)" "unprognostic (2.85e-1)" "unprognostic (1.23e-1)" "unprognostic (3.86e-2)" "unprognostic (1.52e-1)" "unprognostic (7.83e-2)" "unprognostic (2.50e-2)" "unprognostic (5.86e-2)" 2.5 2.7 0.5 1.3 0.6 0.9 3.4 0.8 1.7 1.8 0.2 0.9 0.0 1.2 0.0 0.8 1.2 2.0 0.7 0.5 0.5 2.7 1.6 1.4 1.2 0.5 0.5 1.8 4.0 0.3 0.3 1.4 0.5 1.5 2.3 5.8 0.8 1.9 2.2 1.9 0.8 2.0 0.5 0.7 1.0 0.9 0.4 2.3 2.8 3.5 1.6 0.9 0.6 0.9 1.3 2.1 10.1 3.1 1.6 5.0 7.7 0.2 0.1 2.4 0.0 0.7 1.0 0.5 9.4 4.0 11.0 0.0 3.2 0.2 11.0 0.0 0.0 1.6 7.0 3.1 4.2 4.4 0.4 0.0 0.1 0.9 5.9 5.4 7.9 0.0 12.7 0.7 5.0 3.9 0.0 1.2 0.0 1.0 7.7 10.5 1.3 7.9 4.4 6.6 1.2 7.3 0.2 2.1 6.4 7.2 0.0 0.0 16.1 5.6 0.9 3.6 0.5 3.4 8.5 0.1 0.0 3.8 8.6 0.0 0.0 0.4 0.2 0.0 0.0 0.1 0.1 0.0 0.1 0.3 0.2 0.2 0.0 0.3 0.0 0.2 0.0 0.0 0.5 0.6 0.8 1.7 0.5 0.5 0.5 0.5 0.5 0.5 0.4 0.9 69.5 60.9 96.2 52.5 79.7 44.5 63.7 26.9 55.8 78.2 57.9 55.8 110.7 38.6 57.3 35.0 102.2 37.9 101.1 38.7 1.9 48.1 37.8 88.7 109.5 71.7 58.6 59.7 116.7 36.3 50.2 57.0 57.1 127.3 58.2 66.0 28.9 32.0 31.7 94.2 96.4 39.3 24.4 27.7 36.9 21.1 58.7 53.3 28.4 57.1 62.3 41.7 76.2 57.3 86.8 52.2 26.0 54.5 72.3 57.9 18.5 10.9 39.9 125.1 52.6 104.3 74.0 85.8 60.4 60.0 43.3 48.2 86.3 69.0 50.0 64.5 BEAN1 SCA31 ENSG00000166546 "Brain expressed associated with NEDD4 1" Q3B7T3 16 66427295-66493529 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 5.1" "Cell type enhanced" "Detected in some" "Cytotrophoblasts: 5.8;Early spermatids: 10.7;Excitatory neurons: 9.9;Extravillous trophoblasts: 10.9;Inhibitory neurons: 7.7;Late spermatids: 13.6;Oligodendrocyte precursor cells: 7.5;Spermatocytes: 6.6" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in single" "neutrophil: 1.8" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "AN3-CA: 9.2;BEWO: 4.2;RPTEC TERT1: 9.1;U-87 MG: 4.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA053851 Uncertain Uncertain Nucleoplasm,Centrosome NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 38: Extravillous trophoblasts - Unknown function" Nucleoplasm Centrosome "HPA053851: AB_2682280" "unprognostic (1.92e-1)" "unprognostic (5.79e-4)" "unprognostic (3.83e-2)" "unprognostic (3.38e-3)" "unprognostic (1.01e-1)" "unprognostic (4.04e-2)" "unprognostic (2.16e-1)" "unprognostic (1.13e-1)" "unprognostic (4.89e-1)" "unprognostic (1.59e-1)" "unprognostic (2.13e-3)" "unprognostic (4.18e-2)" "unprognostic (3.38e-2)" "unprognostic (1.63e-1)" "unprognostic (3.10e-2)" "unprognostic (1.98e-1)" "unprognostic (2.10e-2)" 0.7 0.3 1.3 0.3 1.2 0.8 0.6 2.4 4.1 0.8 0.0 0.6 0.2 0.8 0.3 0.6 1.1 0.4 0.9 2.4 0.7 0.5 0.7 0.6 0.2 5.1 1.6 0.9 0.5 0.6 0.3 1.5 5.0 0.4 0.2 1.7 0.5 0.1 1.0 0.9 0.4 0.2 0.7 0.4 0.4 1.1 3.0 0.0 0.7 0.1 0.2 0.6 0.6 1.7 0.5 0.8 0.8 9.2 0.1 0.1 4.2 0.2 0.0 0.0 0.0 0.0 0.8 0.1 0.4 0.1 0.4 0.1 0.0 0.1 0.1 0.0 0.4 0.0 0.1 0.4 0.6 0.0 0.0 0.3 1.6 0.4 0.1 1.3 0.0 0.1 0.0 0.1 0.1 0.2 0.0 0.2 0.2 0.1 0.4 0.0 0.1 0.3 9.1 0.3 0.0 0.1 0.1 0.1 1.4 0.5 0.1 0.0 0.1 0.2 2.0 0.0 0.3 0.3 0.0 0.0 4.8 0.1 1.0 0.2 0.2 0.7 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 1.8 0.1 0.0 0.9 0.0 0.0 1.3 1.2 2.4 4.1 2.4 0.7 5.1 1.6 5.0 0.7 3.0 1.7 0.1 0.0 0.0 2.0 0.0 0.1 0.3 0.2 0.0 0.6 0.2 0.6 1.4 0.0 0.2 0.0 0.0 5.8 0.0 0.1 0.0 0.4 10.7 0.2 0.2 0.4 0.0 0.0 9.9 0.0 10.9 0.4 0.0 0.2 0.0 0.3 0.7 0.0 1.0 0.0 7.7 0.0 0.0 0.8 0.4 13.6 0.3 0.1 3.6 3.7 0.0 0.0 1.0 7.5 2.6 1.7 0.0 2.2 0.0 1.7 0.0 0.1 0.1 1.4 0.0 0.2 0.3 6.6 0.3 0.0 0.1 2.9 0.1 0.5 0.0 0.8 BEST1 "BEST, BMD, RP50, VMD2" ENSG00000167995 "Bestrophin 1" O76090 11 61950063-61965515 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Ion transport, Sensory transduction, Transport, Vision" "Chloride channel, Ion channel" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 26.3;brain: 41.7" "Cell type enhanced" "Detected in many" "Langerhans cells: 272.8" "Group enriched" "Detected in some" 6 "glioma: 2.0;melanoma: 6.6" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 7 "neutrophil: 37.6" "Lineage enriched" "Detected in many" 7 "granulocytes: 37.6" "Cell line enriched" "Detected in many" 4 "SK-MEL-30: 71.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA057464 Enhanced NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 11: Alveolar cells - Smell perception" "HPA057464: AB_2683444" "unprognostic (2.41e-3)" "unprognostic (3.67e-2)" "unprognostic (5.91e-3)" "unprognostic (1.21e-1)" "unprognostic (1.25e-1)" "unprognostic (2.73e-1)" "unprognostic (1.53e-2)" "unprognostic (1.04e-1)" "unprognostic (1.23e-1)" "unprognostic (3.26e-1)" "unprognostic (1.07e-3)" "unprognostic (2.06e-1)" "unprognostic (4.27e-10)" "unprognostic (1.38e-1)" "unprognostic (4.93e-2)" "unprognostic (3.59e-3)" "unprognostic (2.72e-3)" 9.1 3.7 16.3 8.3 30.5 26.3 5.3 24.9 23.2 5.3 10.2 3.8 1.7 4.1 10.0 2.8 5.9 5.1 5.7 16.5 20.2 3.7 2.6 10.3 2.3 27.9 27.3 4.6 2.5 0.3 3.4 2.4 26.7 4.0 1.0 6.7 2.2 2.0 1.6 2.7 3.9 1.8 19.2 11.0 3.3 5.4 28.6 0.4 2.7 1.4 0.4 5.3 4.7 41.7 0.8 0.8 0.4 0.7 17.7 3.8 1.4 1.0 1.8 0.4 1.3 0.5 0.5 0.1 1.7 1.1 2.0 1.1 0.0 0.0 0.3 0.3 0.2 0.0 6.7 0.9 4.9 0.2 0.5 5.6 1.6 1.9 4.1 1.8 0.0 0.8 0.8 7.6 1.9 0.6 0.1 0.6 0.0 0.8 2.1 0.0 0.1 0.3 0.0 2.0 1.0 0.9 1.6 0.1 71.6 0.8 0.7 2.3 0.2 0.9 0.5 0.7 0.3 10.3 0.8 0.7 4.8 0.6 1.2 2.6 3.9 3.9 0.2 4.6 0.2 0.7 0.2 0.1 2.6 0.2 0.1 0.1 37.6 0.1 5.1 0.4 0.3 1.9 16.3 30.5 24.9 23.2 16.5 20.2 27.9 27.3 26.7 19.2 28.6 41.7 2.7 25.6 59.3 9.1 11.4 36.3 6.3 54.8 18.8 2.0 22.0 7.4 3.3 14.3 57.2 1.8 0.0 14.5 5.6 22.5 0.0 3.8 8.3 5.3 9.0 16.4 10.3 29.0 0.3 3.3 23.4 32.4 9.2 9.0 76.4 1.9 21.0 13.8 37.1 0.0 0.7 10.7 22.4 75.4 272.8 2.9 15.2 49.0 55.2 1.0 14.1 6.0 3.1 17.1 43.0 3.1 21.0 6.8 5.9 11.8 28.0 5.6 37.7 9.6 6.6 16.1 20.8 3.2 4.1 6.2 32.7 20.4 24.5 0.9 11.9 13.2 BFSP1 "CP115, CP94, filensin, LIFL-H" ENSG00000125864 "Beaded filament structural protein 1" Q12934 20 17493905-17569220 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Eye lens protein" Cataract "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Late spermatids: 5.7;NK-cells: 17.5;Spermatogonia: 11.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "gdT-cell: 2.5" "Lineage enhanced" "Detected in single" "T-cells: 2.5" "Cell line enhanced" "Detected in many" "hTERT-RPE1: 10.8;RPTEC TERT1: 19.5;SK-BR-3: 10.6" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 5 "amygdala: 2.5;cerebral cortex: 3.2;hippocampal formation: 3.6" "HPA040748, HPA042038" Enhanced Supported "Plasma membrane,Cytosol" No No "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 43: Testis - Unknown function" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" "Plasma membrane, Cytosol" "HPA040748: AB_10963786, HPA042038: AB_10964054" "unprognostic (2.24e-3)" "unprognostic (1.99e-1)" "unprognostic (1.63e-1)" "prognostic favorable (1.39e-4)" "unprognostic (1.07e-2)" "unprognostic (2.21e-1)" "unprognostic (1.22e-6)" "unprognostic (5.11e-2)" "unprognostic (5.53e-1)" "unprognostic (2.10e-4)" "unprognostic (1.75e-1)" "unprognostic (8.81e-2)" "unprognostic (3.35e-4)" "unprognostic (4.45e-2)" "unprognostic (2.73e-2)" "unprognostic (1.78e-2)" "unprognostic (7.50e-2)" 1.1 1.3 2.0 0.5 2.2 0.4 1.1 1.6 2.1 1.3 2.0 1.3 0.3 1.8 1.4 1.1 1.3 1.3 0.7 2.2 2.1 3.7 0.3 1.7 0.3 1.7 1.8 1.5 1.9 1.0 0.9 1.9 1.8 1.2 0.5 0.4 1.5 1.1 0.3 1.0 0.7 1.1 1.5 0.4 0.9 3.8 2.1 0.2 2.5 0.4 0.3 1.3 0.9 2.4 0.8 8.1 2.6 0.3 0.7 2.6 0.4 2.0 9.5 1.3 1.2 3.7 7.0 0.0 1.6 1.2 5.1 1.2 2.8 1.6 1.0 1.8 2.1 0.6 1.2 1.1 1.5 0.5 0.9 3.1 4.9 0.7 2.3 10.8 5.7 0.5 0.3 0.4 4.2 1.6 0.0 1.2 6.1 5.2 2.2 0.0 1.8 0.4 19.5 1.5 2.7 0.3 2.4 10.6 4.3 1.2 5.2 1.8 6.5 0.3 0.6 0.7 2.0 0.0 0.1 0.0 1.4 0.0 1.6 0.0 0.0 0.0 2.5 0.0 0.1 0.0 0.6 0.4 0.0 0.0 0.0 0.2 0.3 0.7 0.0 0.0 0.0 0.2 2.0 2.2 1.6 2.1 2.2 2.1 1.7 1.8 1.8 1.5 2.1 2.4 3.8 3.2 1.7 0.7 0.0 0.9 0.5 0.7 0.0 0.2 1.9 1.5 1.2 1.5 0.4 0.0 0.0 1.2 2.6 0.1 1.9 0.8 1.3 1.1 0.4 3.1 0.0 0.8 2.1 0.9 1.7 1.2 1.5 0.6 0.0 0.2 3.9 0.2 0.5 0.0 1.2 0.2 0.0 0.0 0.8 5.7 1.8 0.2 1.8 2.8 0.0 1.0 17.5 0.5 1.1 0.8 0.0 0.0 0.4 0.4 0.0 0.3 1.8 0.1 0.0 0.5 1.0 1.1 11.9 1.1 0.9 0.4 1.0 0.4 0.3 0.5 BFSP2 "CP47, CP49, LIFL-L, phakinin" ENSG00000170819 "Beaded filament structural protein 2" Q13515 3 133400056-133475222 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Sensory transduction, Vision" "Eye lens protein" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "B-cells: 6.3;Melanocytes: 5.4;Plasma cells: 10.6" "Cancer enriched" "Detected in single" 7 "testis cancer: 1.7" "Not detected" "Not detected" "Immune cell enriched" "Detected in some" 8 "T-reg: 13.4" "Lineage enriched" "Detected in single" 43 "T-cells: 13.4" "Group enriched" "Detected in some" 6 "Daudi: 2.4;U-698: 2.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA038464, HPA062959" Enhanced Uncertain "Plasma membrane,Cytosol" NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" "Plasma membrane, Cytosol" "HPA038464: AB_10672746, HPA062959: AB_2684912" "unprognostic (1.58e-3)" "unprognostic (7.47e-4)" "unprognostic (1.04e-2)" "unprognostic (2.32e-1)" "unprognostic (9.59e-2)" "unprognostic (4.04e-5)" "unprognostic (8.13e-2)" "unprognostic (5.57e-2)" "unprognostic (6.71e-2)" "unprognostic (1.91e-3)" "unprognostic (1.74e-2)" "unprognostic (4.70e-2)" "unprognostic (1.68e-5)" "unprognostic (2.11e-2)" "unprognostic (1.63e-1)" "unprognostic (8.23e-2)" "unprognostic (2.21e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 2.6 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 1.6 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 13.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.3 1.0 0.0 0.0 0.0 0.0 0.1 0.3 0.2 0.0 0.0 1.8 0.0 0.0 0.1 0.1 0.0 0.2 0.1 0.1 0.1 0.0 0.0 0.4 0.9 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.9 0.0 0.6 0.0 0.0 0.0 0.3 0.0 0.3 0.1 5.4 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 10.6 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.3 0.0 0.6 0.0 1.0 0.1 0.1 0.0 BICD2 KIAA0699 ENSG00000185963 "BICD cargo adaptor 2" Q8TD16 9 92711363-92764833 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "mRNA transport, Protein transport, Translocation, Transport" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skin 1: 63.4" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 83.6;Squamous epithelial cells: 103.2;Suprabasal keratinocytes: 130.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023013, HPA024452" Enhanced Supported "Golgi apparatus,Plasma membrane,Cytosol" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 31: Skin - Epidermis development" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 61: Squamous epithelial cells - Keratinization" "Golgi apparatus, Plasma membrane, Cytosol" "HPA023013: AB_1845352, HPA024452: AB_1845353" "unprognostic (9.99e-3)" "unprognostic (1.98e-1)" "unprognostic (7.84e-3)" "unprognostic (2.81e-2)" "unprognostic (4.33e-2)" "unprognostic (2.86e-1)" "unprognostic (2.37e-2)" "unprognostic (1.47e-1)" "unprognostic (1.04e-1)" "unprognostic (6.54e-3)" "unprognostic (8.12e-2)" "unprognostic (1.48e-1)" "prognostic favorable (1.39e-4)" "unprognostic (1.25e-1)" "unprognostic (2.26e-1)" "unprognostic (3.95e-1)" "unprognostic (1.39e-2)" 15.4 10.6 11.4 13.5 10.0 12.0 10.9 10.9 10.5 20.8 7.8 18.5 4.6 15.5 6.0 47.0 12.8 9.4 19.8 11.1 8.6 9.1 8.5 16.0 14.7 11.0 9.8 12.5 8.9 17.7 6.0 10.4 10.3 11.3 5.0 6.5 14.6 13.1 22.3 63.4 10.4 13.7 10.5 17.3 9.5 9.4 10.0 13.8 10.0 15.3 16.8 15.2 30.9 12.3 32.6 26.5 19.2 19.8 36.6 25.1 27.1 30.8 22.2 17.2 13.6 15.6 14.4 36.3 19.5 34.4 22.0 99.4 21.8 49.1 19.4 17.4 23.5 19.2 25.6 21.7 21.8 26.9 30.0 25.8 67.1 28.8 22.0 20.4 26.0 15.4 19.3 27.5 38.1 21.4 25.6 16.7 13.3 23.8 32.0 27.8 41.8 19.3 27.8 27.0 13.4 20.7 21.7 19.9 14.3 19.2 8.2 12.3 34.9 31.8 21.1 53.9 33.9 22.5 17.5 31.9 26.9 16.3 28.4 1.6 3.4 4.4 1.2 3.6 1.2 1.8 1.4 1.6 3.8 2.0 1.3 1.2 7.5 1.1 5.9 3.2 0.9 1.7 11.4 10.0 10.9 10.5 11.1 8.6 11.0 9.8 10.3 10.5 10.0 12.3 21.7 28.9 12.7 14.7 27.6 73.7 17.1 19.2 83.6 12.8 11.4 10.2 54.5 8.6 16.2 7.3 6.2 8.5 26.1 3.4 3.9 10.1 6.5 21.3 26.7 26.4 10.8 16.0 16.2 5.1 6.5 26.0 5.6 21.1 24.1 13.0 19.2 7.5 14.2 15.2 14.0 1.9 12.2 32.4 30.2 7.6 21.1 40.7 16.0 19.7 38.9 22.0 7.2 9.5 18.5 8.5 3.6 33.4 22.1 18.7 0.8 6.7 14.0 6.4 19.7 23.0 33.1 9.7 8.4 103.2 130.8 7.3 17.2 13.8 3.6 20.3 BRAT1 "BAAT1, C7orf27, MGC22916" ENSG00000106009 "BRCA1 associated ATM activator 1" Q6PJG6 7 2537810-2555694 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "DNA damage" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029455, HPA076508" Approved Supported Nucleoplasm NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 52: Non-specific - Transcription" Nucleoplasm "HPA029455: AB_10600761, HPA076508: AB_2686803" "unprognostic (2.53e-1)" "unprognostic (2.24e-1)" "unprognostic (1.19e-2)" "unprognostic (7.04e-3)" "unprognostic (6.07e-3)" "unprognostic (8.95e-2)" "prognostic unfavorable (8.02e-4)" "unprognostic (2.03e-1)" "unprognostic (1.76e-1)" "unprognostic (2.46e-1)" "unprognostic (1.10e-3)" "unprognostic (4.69e-2)" "prognostic unfavorable (3.90e-4)" "unprognostic (5.37e-2)" "unprognostic (3.12e-2)" "unprognostic (8.88e-2)" "unprognostic (3.71e-2)" 17.4 31.0 10.7 6.8 10.9 7.9 17.8 10.4 14.3 22.5 9.6 16.2 8.8 19.4 2.2 15.1 19.2 3.7 14.5 10.4 11.2 15.2 20.7 12.2 7.2 13.5 11.4 21.6 20.2 5.2 19.8 4.5 10.1 24.5 1.3 0.9 17.4 6.6 14.8 21.6 16.6 2.5 10.6 21.1 19.6 31.5 11.2 5.0 18.7 3.7 2.1 17.6 18.8 10.5 35.1 31.1 7.5 27.2 6.8 6.3 24.5 11.7 6.5 10.1 8.5 22.5 21.5 26.3 18.1 7.8 19.4 35.1 8.8 13.7 1.6 10.4 44.4 12.2 23.5 14.3 8.7 16.5 18.2 10.6 9.5 10.2 3.0 5.8 11.4 20.2 39.1 9.6 7.1 50.0 11.8 77.9 35.3 8.8 47.0 28.6 21.9 25.5 6.5 11.3 19.5 30.2 17.1 29.8 12.9 3.5 26.5 33.4 11.8 13.8 43.3 28.5 23.2 20.7 17.3 19.0 15.2 32.8 33.2 5.1 30.8 17.5 21.9 28.2 19.3 18.6 19.8 22.6 32.4 15.2 16.3 17.9 25.4 15.9 27.1 22.7 18.4 22.8 10.7 10.9 10.4 14.3 10.4 11.2 13.5 11.4 10.1 10.6 11.2 10.5 10.1 12.8 6.4 19.9 11.1 7.8 17.5 22.6 16.5 12.8 11.3 8.9 6.8 15.7 14.8 9.2 12.5 21.1 15.0 14.8 15.6 10.6 20.8 7.1 12.3 13.0 11.4 10.3 14.2 13.8 12.9 12.8 26.0 7.5 14.0 34.9 15.4 15.3 34.2 3.3 16.2 14.8 8.2 13.1 6.7 9.4 22.7 13.3 7.2 12.2 17.6 14.4 9.2 13.6 11.3 12.0 12.1 22.2 14.4 9.1 15.0 16.6 8.1 11.9 6.6 9.4 10.7 28.8 39.5 8.0 6.8 14.6 11.9 31.7 17.9 7.6 BSCL2 "GNG3LG, seipin, SPG17" ENSG00000168000 "BSCL2 lipid droplet biogenesis associated, seipin" Q96G97 11 62690275-62709845 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Lipid degradation, Lipid metabolism" "Congenital generalized lipodystrophy, Diabetes mellitus, Disease variant, Hereditary spastic paraplegia, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 292.1;pituitary gland: 237.0" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 35.9;Late spermatids: 53.1;Plasma cells: 86.3;Spermatocytes: 32.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Karpas-707: 242.1;RPMI-8226: 176.1;SCLC-21H: 181.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042394 Approved NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 2: Karpas-707 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" "HPA042394: AB_10794047" "unprognostic (7.78e-2)" "unprognostic (8.74e-2)" "unprognostic (1.24e-1)" "unprognostic (8.17e-2)" "unprognostic (3.08e-2)" "unprognostic (2.01e-1)" "unprognostic (1.70e-1)" "unprognostic (1.13e-1)" "unprognostic (9.30e-2)" "unprognostic (4.44e-2)" "unprognostic (5.13e-3)" "unprognostic (2.41e-1)" "prognostic favorable (7.55e-5)" "unprognostic (3.56e-1)" "unprognostic (1.69e-1)" "unprognostic (1.70e-1)" "unprognostic (1.96e-1)" 24.9 88.1 126.6 7.4 133.2 12.0 26.2 75.0 155.6 38.2 85.4 24.3 10.8 28.4 156.7 24.1 63.7 21.5 18.7 134.9 292.1 50.8 39.3 26.7 15.3 138.1 139.0 32.7 79.4 61.7 237.0 10.0 203.4 35.4 13.3 52.6 66.1 30.3 30.9 25.1 17.2 13.7 83.1 16.2 37.1 190.3 169.3 14.4 37.9 15.5 8.9 17.5 26.1 89.9 18.0 61.7 49.6 83.8 130.8 41.5 7.2 7.2 34.4 13.6 14.5 9.6 26.3 11.9 16.5 25.2 11.8 62.1 5.2 21.8 7.0 30.7 5.0 10.9 33.4 7.8 27.7 9.7 13.5 27.8 16.6 26.9 10.9 19.7 10.8 33.0 7.8 242.1 19.8 44.0 11.4 21.8 132.4 13.9 13.0 21.3 4.2 176.1 65.0 2.4 181.2 29.4 28.2 13.9 25.3 5.7 41.3 15.3 6.5 16.5 3.7 24.5 4.2 32.2 72.5 16.6 82.4 3.2 14.5 26.6 59.2 34.6 24.7 46.2 27.4 27.5 25.5 26.1 42.4 29.7 25.7 27.0 14.2 41.0 40.3 54.3 33.1 43.3 126.6 133.2 75.0 155.6 134.9 292.1 138.1 139.0 203.4 83.1 169.3 89.9 0.8 16.0 5.6 0.0 7.1 1.7 1.0 1.4 35.9 2.5 3.6 2.2 0.2 1.5 1.6 3.7 0.0 2.4 0.9 1.7 3.9 2.0 25.5 4.8 1.5 2.9 0.0 8.8 0.0 1.1 1.9 9.2 20.4 1.5 2.5 0.7 1.4 2.1 1.9 3.3 0.0 1.6 6.1 2.5 3.1 53.1 2.5 6.2 12.4 0.0 0.7 0.8 1.0 0.0 0.0 0.5 1.6 3.0 86.3 0.9 2.5 6.0 23.9 1.2 6.6 1.2 4.1 32.6 18.1 24.7 4.0 1.5 6.5 0.7 1.2 0.5 C12orf65 "FLJ38663, SPG55" ENSG00000130921 "Chromosome 12 open reading frame 65" Q9H3J6 12 123233385-123258079 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Protein biosynthesis" RNA-binding "Disease variant, Hereditary spastic paraplegia, Neurodegeneration, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 60.0" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA057595 Approved Approved Nucleoplasm,Mitochondria,Cytosol No Yes "Cluster 12: Non-specific - Basic cellular processes" "Cluster 63: T-cells - Adaptive immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" "Nucleoplasm, Cytosol" Mitochondria "HPA057595: " "unprognostic (9.07e-3)" "unprognostic (1.51e-2)" "unprognostic (5.30e-2)" "unprognostic (8.19e-3)" "unprognostic (1.23e-1)" "unprognostic (2.58e-1)" "prognostic unfavorable (4.29e-9)" "unprognostic (9.33e-3)" "unprognostic (2.39e-1)" "unprognostic (2.50e-2)" "unprognostic (6.33e-3)" "unprognostic (1.20e-2)" "unprognostic (2.01e-2)" "unprognostic (3.89e-2)" "unprognostic (3.19e-2)" "unprognostic (9.83e-3)" "prognostic favorable (7.82e-5)" 7.3 12.6 16.2 10.2 16.1 9.0 8.0 23.0 19.6 13.0 13.5 10.9 11.4 12.1 13.8 9.5 11.4 8.2 15.0 16.0 13.2 12.6 14.5 8.9 18.2 12.6 12.3 17.2 8.5 10.2 19.7 7.3 14.9 13.7 8.2 15.7 16.2 9.0 13.0 13.8 11.3 7.0 8.8 12.8 10.6 16.7 14.8 60.0 12.3 12.5 13.4 10.3 11.0 18.3 28.4 20.5 20.8 39.1 12.0 11.1 13.7 22.3 16.5 25.1 18.0 21.8 15.8 36.1 20.3 8.4 23.5 20.4 25.7 12.5 25.0 29.2 22.5 44.0 20.7 18.6 26.1 20.4 19.7 14.2 33.2 18.9 35.1 37.0 17.0 53.6 45.6 13.4 16.7 12.3 46.2 39.3 13.7 25.6 31.7 35.7 25.9 33.5 22.8 13.0 40.7 18.2 24.0 8.8 23.4 16.5 18.3 24.7 14.8 23.1 27.3 23.3 24.4 22.7 28.3 32.6 17.1 26.2 28.1 85.3 12.9 50.6 53.9 14.9 67.6 83.9 72.3 71.9 21.7 73.5 96.6 78.2 11.8 63.3 16.3 36.6 73.1 33.5 16.2 16.1 23.0 19.6 16.0 13.2 12.6 12.3 14.9 8.8 14.8 18.3 46.0 41.7 47.7 9.8 54.3 45.4 36.7 29.4 59.2 34.5 23.3 50.0 52.7 14.3 18.0 25.8 14.6 41.1 56.2 16.4 60.7 20.7 22.9 12.2 24.2 27.9 9.6 37.0 13.7 10.8 22.8 41.3 23.0 11.2 15.2 24.1 18.5 33.5 14.3 45.4 15.9 20.7 28.5 9.2 24.2 6.2 37.9 19.7 24.9 7.5 26.3 35.7 44.3 14.6 10.4 13.6 17.4 42.2 42.2 22.8 19.9 39.3 14.8 36.6 13.1 42.7 33.1 115.2 59.7 40.6 36.1 10.8 63.0 43.3 20.8 8.0 C19orf12 "DKFZP762D096, MGC10922, MPAN, NBIA4, SPG43" ENSG00000131943 "Chromosome 19 open reading frame 12" Q9NSK7 19 29698886-29715789 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adipose tissue: 118.9;tongue: 105.5" "Cell type enhanced" "Detected in all" "Hepatocytes: 62.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046930 Approved Supported Cytosol NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 44: HDLM-2 - Immune response" "Cluster 2: Hepatocytes - Metabolism" Cytosol "HPA046930: AB_10962836" "unprognostic (1.76e-1)" "unprognostic (2.22e-1)" "unprognostic (2.13e-1)" "unprognostic (1.01e-2)" "unprognostic (1.45e-1)" "unprognostic (1.14e-1)" "unprognostic (1.31e-1)" "unprognostic (9.01e-2)" "unprognostic (1.54e-1)" "unprognostic (9.94e-3)" "unprognostic (7.93e-3)" "unprognostic (5.27e-2)" "unprognostic (1.69e-2)" "unprognostic (1.74e-1)" "unprognostic (2.23e-1)" "unprognostic (3.22e-1)" "unprognostic (1.22e-3)" 118.9 25.3 22.1 14.4 25.8 4.4 40.8 16.6 24.8 13.8 12.6 16.8 19.5 14.3 9.0 13.2 12.8 12.9 30.9 23.9 22.7 20.8 69.3 11.3 21.2 20.5 20.3 14.7 17.1 15.4 14.5 13.2 21.7 14.1 9.3 8.5 18.1 12.4 62.2 14.7 17.6 13.4 16.8 16.0 12.9 7.3 23.1 14.1 10.7 105.5 13.6 15.2 11.7 19.9 19.9 39.4 18.4 23.2 45.0 27.5 28.8 23.1 22.7 22.5 29.2 19.1 8.1 16.1 24.1 29.1 20.4 8.5 15.7 9.5 15.1 42.8 28.3 18.0 13.5 33.2 25.1 14.0 22.8 31.8 20.2 13.7 10.9 18.0 20.1 9.8 14.0 20.3 23.7 13.8 9.9 10.1 11.1 17.3 9.9 19.2 19.1 12.3 17.2 20.1 11.3 23.8 13.9 17.8 37.0 18.8 7.6 15.4 20.9 47.4 37.0 19.5 21.2 28.4 27.1 12.0 28.3 8.4 20.3 1.1 2.3 1.4 16.0 2.5 9.4 4.6 9.1 11.6 2.2 3.6 9.2 11.5 2.8 7.1 2.7 5.0 11.9 8.0 22.1 25.8 16.6 24.8 23.9 22.7 20.5 20.3 21.7 16.8 23.1 19.9 9.6 12.8 13.7 9.4 13.7 12.7 11.1 8.2 14.8 15.8 13.2 9.4 30.1 2.8 7.3 9.2 6.2 29.2 21.7 9.2 15.6 17.1 1.8 8.5 16.0 10.4 3.6 9.5 19.5 23.1 25.5 20.0 8.2 8.8 16.5 16.2 14.6 62.4 15.6 5.0 18.3 7.5 8.2 12.5 9.9 1.8 28.9 8.7 10.6 8.4 20.1 15.8 41.2 12.1 17.4 20.0 11.0 29.3 20.7 12.8 24.0 37.5 6.6 9.6 6.6 24.6 13.3 4.6 5.3 10.1 7.7 21.9 21.6 23.8 8.2 7.8 C1QTNF5 "CTRP5, DKFZp586B0621, LORD" ENSG00000223953 "C1q and TNF related 5" Q9BXJ0 11 119338942-119340940 "Disease related genes, Human disease related genes, Predicted secreted proteins" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in some" "Ductal cells: 4.7;Endothelial cells: 1.5;Exocrine glandular cells: 1.1;Fibroblasts: 3.6;Gastric mucus-secreting cells: 1.5;Smooth muscle cells: 1.2" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC diff: 17.7;fHDF/TERT166: 14.7;HHSteC: 35.8;hTERT-RPE1: 28.5;HUVEC TERT2: 54.7;TIME: 50.5" "Low region specificity" "Detected in all" "CAB025607, HPA038604" Uncertain "Secreted to blood" NA NA 219000000 1500000 "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 50: Fibroblasts - ECM organization" "CAB025607: , HPA038604: AB_2676110" 51.9 13.4 19.1 12.9 20.8 0.1 36.6 20.3 20.7 38.4 25.5 23.0 14.9 50.7 7.5 11.5 27.2 45.5 36.1 17.3 19.8 42.4 11.1 42.0 8.9 21.8 22.2 11.3 18.8 6.8 14.8 13.6 20.4 19.5 7.8 2.2 16.9 8.7 8.8 20.4 24.2 26.8 21.7 32.3 27.1 2.6 27.5 2.8 32.0 15.2 4.6 31.6 20.8 21.7 0.0 0.0 3.3 0.0 17.7 4.9 0.2 4.6 0.3 0.6 2.7 0.1 0.0 0.1 2.0 14.7 0.0 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.7 35.8 0.0 0.0 8.4 0.0 0.3 0.0 28.5 54.7 0.0 0.0 0.1 2.8 0.0 0.0 0.0 0.9 0.0 0.1 0.0 4.1 0.0 0.1 0.0 0.0 6.5 0.0 0.0 1.1 0.9 0.0 0.0 50.5 0.0 0.2 0.2 0.0 0.0 0.1 0.0 0.2 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.1 20.8 20.3 20.7 17.3 19.8 21.8 22.2 20.4 21.7 27.5 21.7 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.7 0.0 0.0 0.1 1.5 0.0 0.0 0.0 1.1 0.0 3.6 1.5 0.0 0.0 0.0 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 C2 ENSG00000166278 "Complement C2" P06681 6 31897785-31945672 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Complement pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Age-related macular degeneration, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "liver: 477.9" "Group enriched" "Detected in many" 4 "Alveolar cells type 2: 142.4;Hepatocytes: 380.3;Hofbauer cells: 282.7;Kupffer cells: 99.3" "Cancer enriched" "Detected in all" 9 "liver cancer: 100.2" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 4 "intermediate monocyte: 21.1;non-classical monocyte: 25.9" "Lineage enriched" "Detected in single" 35 "monocytes: 25.9" "Cell line enriched" "Detected in some" 5 "Karpas-707: 284.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" CAB016775 Supported "Secreted to blood" NA NA 34000000000 "Cluster 51: Monocytes - Innate immune response" "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 2: Karpas-707 - Immune response" "Cluster 15: Hepatocytes - Hemostasis" "CAB016775: " "unprognostic (2.05e-1)" "unprognostic (1.22e-1)" "unprognostic (7.68e-2)" "unprognostic (1.49e-3)" "unprognostic (7.40e-2)" "unprognostic (3.34e-2)" "unprognostic (1.36e-2)" "unprognostic (8.88e-3)" "unprognostic (3.02e-1)" "unprognostic (2.59e-3)" "unprognostic (3.27e-2)" "unprognostic (3.15e-3)" "prognostic unfavorable (2.64e-7)" "unprognostic (2.05e-1)" "unprognostic (4.42e-2)" "unprognostic (7.37e-2)" "unprognostic (2.55e-2)" 42.6 12.1 0.8 27.6 1.0 3.2 11.7 0.9 1.4 8.1 1.7 14.3 16.7 7.0 1.3 7.6 12.0 23.0 8.5 0.7 1.1 23.2 477.9 80.0 27.8 3.0 2.6 5.3 1.9 0.9 3.8 48.4 3.0 5.4 13.0 0.4 9.1 0.9 2.1 5.8 30.2 23.6 2.1 46.3 12.0 4.1 3.7 5.5 3.3 2.7 12.5 23.6 5.3 2.1 0.3 0.1 0.1 0.6 0.1 0.0 6.8 0.5 0.3 0.4 0.3 0.4 0.3 0.6 3.5 1.0 0.6 0.5 0.1 0.0 0.3 0.2 0.4 0.3 0.4 52.8 1.1 0.1 0.7 2.7 0.3 0.6 0.1 0.6 0.0 0.7 0.5 284.0 0.0 0.0 0.4 0.5 0.3 0.1 0.0 0.2 16.5 3.0 0.0 0.1 0.3 0.3 2.6 0.3 0.2 0.3 0.2 9.5 0.2 0.2 0.7 0.5 0.1 0.9 31.6 2.7 0.8 0.9 0.1 0.1 5.6 0.0 0.1 21.1 0.1 0.0 0.0 0.0 0.7 0.1 0.1 0.1 0.5 0.1 25.9 0.0 0.0 2.2 0.8 1.0 0.9 1.4 0.7 1.1 3.0 2.6 3.0 2.1 3.7 2.1 2.1 25.6 142.4 2.6 1.9 3.3 1.1 2.0 0.6 1.4 1.3 1.3 0.6 25.8 11.2 1.8 0.0 2.1 0.1 1.8 0.0 0.6 0.3 1.5 18.7 1.9 2.4 10.7 6.6 2.7 2.7 19.8 3.1 1.3 3.8 0.2 21.0 380.3 282.7 1.7 6.3 11.3 0.0 99.3 5.0 1.3 6.8 32.6 3.6 7.5 7.3 0.1 0.0 1.0 1.7 4.5 33.1 1.2 0.4 4.0 55.2 35.7 9.4 0.9 0.0 5.6 3.5 0.8 1.4 0.7 2.8 4.0 2.0 0.5 15.8 4.5 C3 "ARMD9, C3a, C3b, CPAMD1" ENSG00000125730 "Complement C3" P01024 19 6677704-6730562 "Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Complement alternate pathway, Complement pathway, Fatty acid metabolism, Immunity, Inflammatory response, Innate immunity, Lipid metabolism" "Age-related macular degeneration, Disease variant, FDA approved drug targets, Hemolytic uremic syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 8 "liver: 4761.3" "Cell type enriched" "Detected in many" 5 "Hepatocytes: 4512.2" "Cancer enriched" "Detected in all" 5 "liver cancer: 1213.6" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 4 "non-classical monocyte: 13.3" "Lineage enriched" "Detected in many" 4 "monocytes: 13.3" "Group enriched" "Detected in many" 7 "BJ hTERT+: 357.8;EFO-21: 738.6;Hep G2: 795.3;HSkMC: 534.8;SiHa: 209.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA003563, CAB004209, HPA020432" Enhanced "Secreted to blood" NA NA 1260000000000 200000000000 "Cluster 51: Monocytes - Innate immune response" "Cluster 62: Liver - Hemostasis" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 15: Hepatocytes - Hemostasis" "CAB004209: AB_627277, HPA003563: AB_1847117, HPA020432: AB_1847118" "unprognostic (3.26e-3)" "unprognostic (3.91e-1)" "unprognostic (3.92e-1)" "unprognostic (5.98e-3)" "unprognostic (3.31e-1)" "unprognostic (1.04e-1)" "prognostic favorable (8.11e-4)" "unprognostic (1.99e-1)" "unprognostic (9.26e-2)" "unprognostic (5.80e-2)" "unprognostic (8.12e-3)" "unprognostic (5.48e-2)" "prognostic unfavorable (1.09e-5)" "unprognostic (2.63e-2)" "unprognostic (2.49e-2)" "unprognostic (6.03e-3)" "unprognostic (3.88e-1)" 585.2 286.5 46.0 194.3 53.7 1.5 213.9 47.8 46.0 237.5 31.5 128.9 22.9 82.9 41.1 76.4 350.3 354.9 221.6 36.5 81.8 51.4 4761.3 176.0 68.2 143.3 99.2 228.1 182.7 17.9 21.8 17.7 116.4 35.4 76.5 11.7 155.6 57.4 36.6 51.4 156.4 123.0 89.9 7.1 107.9 41.1 103.4 34.1 92.4 52.0 126.4 363.3 101.3 121.9 65.0 23.0 0.0 0.1 10.8 36.0 74.7 5.2 357.8 6.8 12.6 3.6 49.5 1.9 738.6 0.3 54.2 46.6 0.2 43.1 6.9 24.0 0.5 3.1 31.2 795.3 16.3 6.2 9.1 534.8 12.8 60.8 27.3 9.5 0.0 0.0 2.1 0.8 0.2 1.0 0.6 1.6 1.5 0.7 0.1 0.4 5.0 0.3 32.1 6.2 0.5 0.5 209.5 0.1 0.5 0.1 17.2 8.8 3.5 5.7 7.4 4.8 3.6 1.6 4.8 4.5 75.1 4.5 0.3 1.7 1.3 0.6 0.3 2.5 0.2 0.5 0.2 0.1 0.7 0.5 0.2 0.2 3.0 1.3 13.3 0.5 0.1 0.9 46.0 53.7 47.8 46.0 36.5 81.8 143.3 99.2 116.4 89.9 103.4 121.9 36.4 76.9 473.9 0.7 29.4 27.5 14.7 141.5 0.6 0.7 19.5 23.4 14.5 783.5 422.5 16.5 0.0 1.4 2.0 0.2 5.9 494.1 45.9 23.0 63.5 26.2 0.0 209.9 0.4 136.7 1.4 482.2 17.9 57.7 5.1 0.1 124.9 4512.2 34.4 0.0 0.5 0.9 20.3 164.5 44.8 97.5 226.2 45.1 35.6 70.3 14.6 1.2 0.0 0.5 0.6 376.4 0.2 10.9 3.9 13.3 1.9 53.6 177.5 4.6 6.6 20.1 49.1 4.0 7.7 5.2 21.9 2.7 15.0 0.1 0.4 38.2 C8orf37 "BBS21, CORD16, FAP418, FLJ30600, MOT25, RP64" ENSG00000156172 "Chromosome 8 open reading frame 37" Q96NL8 8 95244913-95269201 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Bardet-Biedl syndrome, Ciliopathy, Cone-rod dystrophy, Disease variant, Obesity, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024198 Approved Approved "Plasma membrane,Cell Junctions,Cytosol" NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 21: OE19 - Mitochondria" "Cluster 66: Spermatocytes - Spermatogenesis" Cytosol "Plasma membrane, Cell Junctions" "HPA024198: AB_1845775" "unprognostic (7.90e-2)" "unprognostic (1.98e-2)" "unprognostic (5.68e-2)" "prognostic unfavorable (4.63e-4)" "unprognostic (2.72e-3)" "unprognostic (4.20e-3)" "unprognostic (2.04e-2)" "unprognostic (8.94e-2)" "unprognostic (1.81e-1)" "unprognostic (1.76e-1)" "unprognostic (6.11e-3)" "unprognostic (2.32e-1)" "unprognostic (1.09e-1)" "unprognostic (6.72e-3)" "unprognostic (2.02e-1)" "unprognostic (1.33e-2)" "unprognostic (3.29e-1)" 1.7 1.8 1.7 1.2 1.9 0.9 2.3 2.3 2.2 2.3 3.2 1.0 0.9 2.4 3.1 1.0 3.9 1.4 2.7 1.7 1.8 2.4 1.8 1.5 2.2 2.3 2.9 4.8 1.2 3.5 2.3 1.8 2.2 2.0 0.9 5.0 1.5 1.7 1.1 1.5 1.0 2.3 2.7 1.7 1.1 1.7 1.8 2.4 2.4 1.8 1.9 1.2 1.4 2.9 2.8 4.5 3.6 1.9 1.2 3.3 1.0 1.2 2.7 1.5 2.0 0.7 6.0 5.6 2.8 2.0 3.8 2.3 1.5 3.1 3.3 1.8 1.4 4.4 2.7 2.0 1.4 0.9 2.3 3.3 1.4 1.8 5.0 3.9 2.3 3.3 2.3 3.2 2.0 2.1 4.8 1.1 1.1 5.6 3.0 2.5 1.9 1.4 3.4 1.2 3.5 3.4 2.5 0.5 2.1 2.7 4.2 0.8 2.0 1.9 2.4 1.6 1.2 2.9 3.0 3.8 3.6 2.1 2.4 0.3 0.3 0.1 0.2 0.2 0.5 0.4 0.3 0.3 0.5 0.8 0.3 0.5 0.4 0.7 0.1 0.2 0.1 0.2 1.7 1.9 2.3 2.2 1.7 1.8 2.3 2.9 2.2 2.7 1.8 2.9 2.4 3.2 2.6 6.8 2.5 0.9 3.7 2.9 4.0 2.7 1.3 2.4 5.3 0.0 3.3 7.3 2.1 2.5 1.8 0.1 7.9 1.8 10.2 3.4 1.3 1.5 0.0 0.4 6.8 2.7 2.9 2.8 1.1 1.0 0.0 1.9 1.1 3.8 1.3 3.3 5.2 0.1 2.0 1.6 1.2 8.7 3.1 0.8 1.8 1.9 1.8 5.3 0.0 8.5 5.7 1.2 0.2 3.0 0.7 1.9 0.1 4.7 7.9 4.1 0.0 2.5 4.2 6.0 3.5 0.9 1.8 0.8 1.1 3.0 0.5 1.8 C9orf72 "DENND9, DENNL72, MGC23980" ENSG00000147894 "C9orf72-SMCR8 complex subunit" Q96LT7 9 27535640-27573866 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Autophagy "Guanine-nucleotide releasing factor" "Amyotrophic lateral sclerosis, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Langerhans cells: 127.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 7 "basophil: 24.3;classical monocyte: 32.0;intermediate monocyte: 44.7;myeloid DC: 25.2;neutrophil: 34.3;non-classical monocyte: 36.9" "Group enriched" "Detected in all" 8 "dendritic cells: 25.2;granulocytes: 34.3;monocytes: 44.7" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA023873 Uncertain Supported "Vesicles,Midbody ring,Cytosol" "Intracellular and membrane" Yes NA "Cluster 7: Monocytes - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 12: NES - Nervous system development" "Cluster 41: Macrophages - Immune response" "Vesicles, Cytosol" "Midbody ring" "HPA023873: AB_1845834" "unprognostic (1.78e-2)" "unprognostic (5.01e-2)" "unprognostic (7.63e-2)" "unprognostic (9.78e-3)" "unprognostic (1.46e-1)" "unprognostic (1.32e-1)" "unprognostic (1.59e-1)" "unprognostic (1.99e-3)" "unprognostic (2.45e-1)" "unprognostic (2.05e-2)" "unprognostic (2.16e-2)" "unprognostic (9.81e-2)" "unprognostic (1.44e-2)" "unprognostic (9.29e-2)" "unprognostic (1.10e-1)" "unprognostic (2.89e-2)" "unprognostic (9.13e-2)" 11.7 12.1 9.5 16.6 9.5 25.3 9.4 21.0 12.5 9.8 12.4 8.8 6.8 12.0 11.3 7.6 16.0 10.2 9.3 9.7 13.5 7.0 16.0 17.7 9.2 14.6 11.9 24.2 9.6 6.9 16.2 12.1 12.5 14.2 7.8 31.3 6.7 5.8 14.9 8.8 8.3 8.6 12.4 16.8 7.8 17.6 11.3 11.1 13.1 9.9 8.8 9.2 8.5 14.5 4.4 3.7 28.7 4.4 5.7 7.0 4.4 5.9 4.9 3.5 1.8 0.4 1.4 10.2 3.7 5.3 7.5 3.1 9.4 7.2 2.5 19.8 3.6 4.9 11.0 3.0 8.9 3.4 5.2 7.3 8.6 0.8 16.1 3.5 7.6 11.1 9.8 18.6 4.3 0.8 6.6 5.0 14.2 6.8 16.0 2.4 9.5 5.1 2.8 3.3 9.9 24.4 4.0 4.4 3.7 10.9 3.7 2.9 6.6 0.0 14.5 8.6 4.0 4.8 15.8 6.8 11.4 11.0 3.8 24.3 32.0 2.4 1.9 44.7 3.3 3.4 2.7 2.5 25.2 2.5 4.6 2.9 34.3 4.3 36.9 3.9 4.0 10.0 9.5 9.5 21.0 12.5 9.7 13.5 14.6 11.9 12.5 12.4 11.3 14.5 15.4 16.0 14.7 19.2 43.2 35.9 50.7 15.0 26.2 22.1 7.2 6.6 15.6 4.3 15.2 7.3 20.9 21.2 11.7 5.0 1.9 8.4 2.6 94.4 11.8 15.0 11.4 3.0 53.0 9.3 7.3 18.7 16.8 57.6 16.5 18.4 8.2 9.3 25.8 11.8 58.9 12.5 10.2 71.9 127.8 4.2 6.2 94.8 19.6 42.2 58.2 45.2 3.1 30.2 60.9 8.6 11.1 3.8 10.7 30.0 4.1 5.4 80.7 27.5 0.0 17.5 20.6 29.2 20.9 15.2 29.1 34.6 18.2 7.9 5.1 37.6 CA4 "CAIV, Car4, RP17" ENSG00000167434 "Carbonic anhydrase 4" P22748 17 60149942-60170899 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Lyase "Disease variant, FDA approved drug targets, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 263.6" "Group enriched" "Detected in many" 16 "Adipocytes: 704.2;Distal enterocytes: 1289.3;Paneth cells: 2368.3" "Cancer enhanced" "Detected in many" "colorectal cancer: 7.3" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 7 "neutrophil: 99.5" "Lineage enriched" "Detected in single" 995 "granulocytes: 99.5" "Cell line enhanced" "Detected in single" "OE19: 1.1" "Region enriched" "Detected in all" 5 "cerebellum: 300.3" "Low region specificity" "Detected in all" "HPA011089, HPA017258" Enhanced Uncertain Vesicles,Cytosol NA NA 190000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 37: Intestine - Unknown function" "Cluster 5: NTERA-2 - Transcription" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol Vesicles "HPA011089: AB_1845996, HPA017258: AB_1845997" "unprognostic (2.07e-2)" "unprognostic (7.85e-2)" "unprognostic (1.55e-2)" "unprognostic (7.78e-3)" "unprognostic (8.42e-2)" "unprognostic (1.19e-1)" "unprognostic (3.19e-2)" "unprognostic (5.84e-2)" "unprognostic (7.76e-2)" "unprognostic (9.74e-2)" "unprognostic (1.54e-1)" "unprognostic (1.71e-2)" "unprognostic (2.68e-3)" "unprognostic (8.59e-2)" "unprognostic (1.43e-1)" "unprognostic (2.45e-1)" "unprognostic (4.57e-2)" 83.0 2.3 17.8 3.1 18.8 19.5 80.9 86.8 34.2 12.7 13.9 263.6 3.8 6.0 51.9 1.0 5.0 38.3 55.2 22.8 13.9 47.6 0.7 87.2 0.6 13.4 17.8 6.2 31.8 16.9 15.7 8.6 22.8 8.2 172.6 0.1 10.4 36.9 30.5 3.8 11.2 2.7 12.7 16.0 10.0 1.3 15.1 1.6 74.6 42.3 0.1 6.2 5.6 14.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 1.1 0.0 0.0 0.0 0.3 0.5 0.0 0.2 0.0 0.0 0.0 0.0 0.7 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 99.5 0.0 0.0 0.0 0.0 0.1 17.8 18.8 86.8 34.2 22.8 13.9 13.4 17.8 22.8 12.7 15.1 14.9 704.2 0.0 2.4 1.3 1.5 1.5 0.3 0.0 2.2 0.0 2.3 2.5 9.1 0.0 0.6 14.7 0.0 0.0 1.2 1289.3 33.2 11.7 0.5 0.6 13.0 88.3 19.3 0.0 3.8 0.2 0.0 4.4 0.0 0.2 11.4 23.2 1.4 0.0 0.6 0.0 1.4 24.6 0.0 0.0 1.2 0.1 0.6 1.1 0.0 23.4 0.0 0.1 0.0 1.0 0.4 0.1 2368.3 0.0 1.2 0.1 14.9 72.4 0.7 0.0 6.6 5.0 23.4 0.1 0.0 0.1 1.1 0.0 2.4 0.4 41.7 0.3 CA8 "CALS, CARP" ENSG00000178538 "Carbonic anhydrase 8" P35219 8 60185412-60281400 "Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 18.3;parathyroid gland: 40.1" "Cell type enhanced" "Detected in many" "Astrocytes: 92.7;Enteroendocrine cells: 35.2;Gastric mucus-secreting cells: 40.2;Oligodendrocyte precursor cells: 129.7" "Cancer enhanced" "Detected in many" "endometrial cancer: 7.8" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 24 "basophil: 76.2" "Lineage enriched" "Detected in many" 24 "granulocytes: 76.2" "Cell line enhanced" "Detected in some" "HEK 293: 10.1;JURKAT: 11.0;K-562: 20.3;NB-4: 12.3;OE19: 17.4" "Region enriched" "Detected in all" 38 "cerebellum: 1260.5" "Region enriched" "Detected in all" 9 "cerebellum: 86.3" "HPA024748, CAB025545, CAB047309" Enhanced NA NA "Cluster 38: Basophils - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 1: K-562 - Erythropoiesis" "Cluster 68: Oligodendrocytes - Mixed function" "CAB025545: , CAB047309: , HPA024748: AB_1846003" "unprognostic (1.55e-1)" "unprognostic (2.89e-2)" "unprognostic (4.43e-2)" "unprognostic (3.46e-3)" "unprognostic (6.67e-2)" "unprognostic (3.19e-1)" "unprognostic (3.85e-2)" "unprognostic (3.54e-2)" "unprognostic (1.28e-1)" "unprognostic (1.19e-1)" "prognostic favorable (5.79e-5)" "unprognostic (3.23e-2)" "unprognostic (1.68e-2)" "unprognostic (2.12e-1)" "unprognostic (1.71e-2)" "unprognostic (1.95e-1)" "unprognostic (1.41e-1)" 1.6 0.9 5.2 0.3 5.8 0.5 4.6 18.3 5.6 4.3 2.0 1.3 1.0 1.9 10.2 0.2 1.5 0.3 4.3 4.4 5.3 5.3 0.0 0.9 0.4 4.7 4.9 0.2 1.9 40.1 8.5 6.2 5.0 1.5 2.0 2.3 3.7 0.2 1.2 0.3 1.0 0.5 3.1 0.8 4.4 4.1 5.1 1.3 0.3 2.3 0.3 0.6 0.3 4.0 0.0 2.4 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.6 0.0 0.0 0.0 1.1 0.0 0.1 0.0 10.1 4.5 0.0 0.0 3.6 1.8 1.2 0.0 0.0 0.0 0.0 0.0 0.0 11.0 20.3 0.2 0.0 0.0 3.3 12.3 0.2 17.4 0.0 0.0 0.0 0.2 0.4 0.8 5.1 0.0 0.0 1.1 0.0 2.0 4.5 0.7 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 5.5 76.2 0.0 0.5 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 3.1 0.0 0.1 5.2 5.8 18.3 5.6 4.4 5.3 4.7 4.9 5.0 3.1 5.1 4.0 22.0 0.0 4.8 92.7 1.6 1.0 0.4 4.1 0.0 8.2 15.6 10.3 4.7 0.0 5.7 3.7 0.0 8.3 10.9 2.0 3.9 8.1 9.9 9.8 2.4 16.7 35.2 13.5 4.7 6.0 0.3 4.0 40.2 26.2 0.0 1.1 0.0 0.0 9.9 0.0 25.6 25.0 6.1 1.9 1.1 4.9 1.5 1.1 7.2 18.7 0.0 2.6 1.0 129.7 0.4 1.6 3.5 1.5 14.0 2.1 0.3 0.0 1.2 1.0 0.0 0.8 2.3 3.8 5.5 0.2 0.4 1.4 0.7 3.1 3.3 1.5 CABP2 DFNB93 ENSG00000167791 "Calcium binding protein 2" Q9NPB3 11 67518912-67524517 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Hearing, Sensory transduction, Vision" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 9 "retina: 7.3" "Cell type enriched" "Detected in some" 14 "Bipolar cells: 100.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in single" 22 "cerebellum: 9.3" "Not detected" "Not detected" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 56: Bipolar cells - Visual perception" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 100.2 0.0 0.0 0.1 0.0 0.0 0.0 4.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.7 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CABP4 CSNB2B ENSG00000175544 "Calcium binding protein 4" P57796 11 67452406-67461752 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in many" 9 "retina: 68.2" "Group enriched" "Detected in many" 6 "Cone photoreceptor cells: 141.8;Rod photoreceptor cells: 254.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "non-classical monocyte: 12.1" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in some" 4 "HMC-1: 19.4" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 79: Retina - Phototransduction" "Cluster 3: HMC-1 - Innate immune response" "Cluster 46: Photoreceptor cells - Phototransduction" "unprognostic (2.24e-1)" "unprognostic (1.26e-1)" "unprognostic (4.23e-2)" "unprognostic (1.22e-2)" "unprognostic (3.78e-3)" "unprognostic (2.91e-2)" "unprognostic (1.03e-3)" "unprognostic (1.76e-1)" "unprognostic (1.49e-1)" "unprognostic (1.44e-2)" "unprognostic (2.32e-3)" "unprognostic (2.57e-1)" "unprognostic (7.10e-4)" "unprognostic (5.35e-2)" "unprognostic (4.63e-2)" "unprognostic (1.10e-1)" "unprognostic (3.44e-3)" 1.2 0.6 1.2 0.5 1.4 0.7 1.4 2.2 1.7 1.4 1.5 0.7 0.6 0.5 1.7 0.3 0.4 0.8 0.5 1.3 1.2 0.8 0.7 1.7 1.0 1.6 1.2 0.2 0.8 0.1 0.1 1.4 1.6 1.4 0.4 68.2 0.9 0.6 0.9 0.7 1.2 0.3 1.1 7.2 1.4 0.2 1.5 0.2 0.5 0.2 0.4 0.6 0.3 2.4 0.0 0.0 0.0 0.2 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.2 4.5 0.1 0.0 0.0 0.1 0.2 0.2 0.1 0.0 0.1 0.2 0.1 4.1 0.1 0.0 0.1 19.4 0.0 0.0 0.1 0.0 0.1 0.6 0.1 0.0 0.6 1.0 0.3 0.0 0.5 0.1 0.0 0.1 0.1 0.1 0.6 0.0 0.2 0.2 0.1 0.0 0.1 0.1 0.0 0.1 0.0 1.9 0.1 0.1 0.3 0.1 0.2 0.0 0.6 0.1 0.2 0.1 4.0 3.3 0.8 0.7 1.7 0.5 0.6 0.6 0.5 2.5 1.1 0.6 0.7 2.7 1.3 12.1 0.9 0.4 3.5 1.2 1.4 2.2 1.7 1.3 1.2 1.6 1.2 1.6 1.1 1.5 2.4 2.2 0.0 0.5 0.3 1.9 0.9 1.2 0.0 0.6 17.0 2.2 2.0 2.0 2.8 0.0 5.5 141.8 0.1 0.9 0.4 0.0 1.6 0.4 3.8 0.6 3.6 0.0 0.0 0.2 1.5 0.2 0.7 2.6 2.8 0.0 0.1 3.9 0.2 3.9 13.5 0.3 0.7 0.0 9.5 1.9 0.2 0.3 1.9 1.8 2.8 0.3 28.9 5.2 0.0 0.4 1.7 0.1 0.0 1.5 1.5 0.1 1.2 0.7 254.4 0.0 4.8 0.6 0.0 0.3 0.2 0.3 0.8 1.4 0.0 0.2 1.0 CACNA1A "APCA, CACNL1A4, Cav2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6" ENSG00000141837 "Calcium voltage-gated channel subunit alpha1 A" O00555 19 13206442-13633025 "Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel, Voltage-gated channel" "Disease variant, Epilepsy, FDA approved drug targets, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 14 "brain: 99.3" "Group enriched" "Detected in many" 8 "Bipolar cells: 101.4;Enteroendocrine cells: 214.1;Excitatory neurons: 318.3;Horizontal cells: 249.0;Inhibitory neurons: 372.1;Oligodendrocyte precursor cells: 271.9" "Low cancer specificity" "Detected in some" "Group enriched" "Detected in all" 4 "cerebellum: 99.3;cerebral cortex: 30.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "SCLC-21H: 45.1;U-87 MG: 23.9" "Low region specificity" "Detected in all" "HPA064258, HPA068138, HPA071902" Enhanced Supported Uncertain "Endoplasmic reticulum" NA NA "Cluster 42: Non-specific - Transcription" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Endoplasmic reticulum" "HPA064258: AB_2685229, HPA068138: , HPA071902: " "unprognostic (1.09e-1)" "unprognostic (3.73e-3)" "unprognostic (2.27e-1)" "unprognostic (2.78e-4)" "unprognostic (4.00e-2)" "unprognostic (2.29e-3)" "unprognostic (5.47e-2)" "unprognostic (3.13e-1)" "unprognostic (2.86e-1)" "unprognostic (1.14e-2)" "prognostic favorable (4.32e-4)" "unprognostic (5.31e-3)" "unprognostic (5.03e-6)" "unprognostic (6.29e-2)" "unprognostic (1.59e-1)" "unprognostic (2.61e-2)" "unprognostic (6.25e-2)" 1.0 2.3 15.4 0.3 15.8 0.1 0.9 99.3 30.4 0.6 0.0 0.7 1.2 0.8 1.1 0.2 3.2 0.1 0.6 15.1 6.8 0.5 0.2 0.2 0.4 7.2 11.2 0.9 2.6 0.1 4.2 0.0 10.6 0.4 0.4 7.1 0.2 0.1 0.5 0.3 1.7 0.2 9.4 0.6 2.7 2.3 11.3 0.1 0.7 0.1 0.2 0.3 0.7 15.2 0.0 0.1 0.1 6.0 0.2 0.2 0.0 2.2 2.5 0.3 0.0 0.0 0.0 0.2 0.0 0.2 5.1 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.9 2.8 0.0 1.9 0.0 0.0 0.0 0.0 0.0 7.2 0.2 0.0 0.1 0.2 1.4 0.1 0.3 0.6 0.0 0.1 0.0 0.1 45.1 0.0 0.0 0.0 0.4 0.1 0.0 1.9 0.1 0.1 0.9 0.2 0.1 0.0 0.0 0.0 23.9 0.1 0.6 0.5 0.0 0.1 0.0 0.0 0.1 0.5 0.1 0.0 0.0 0.3 0.1 0.1 0.3 0.1 0.2 0.1 0.1 0.0 15.4 15.8 99.3 30.4 15.1 6.8 7.2 11.2 10.6 9.4 11.3 15.2 7.7 6.4 3.2 31.3 9.6 0.6 3.4 0.0 0.0 101.4 3.1 7.4 2.8 0.0 1.3 1.8 16.7 0.0 2.9 0.6 0.0 0.5 27.1 1.2 6.3 6.5 214.1 0.4 318.3 0.4 0.2 4.7 10.7 2.6 1.3 5.2 1.8 1.2 0.5 249.0 372.1 5.0 4.1 1.9 1.4 28.0 1.2 2.1 0.0 28.1 1.2 3.0 4.1 271.9 11.5 1.5 0.1 0.4 0.5 0.8 0.2 2.0 3.7 7.0 0.0 5.1 17.6 4.3 7.1 0.4 0.1 0.3 2.0 2.5 1.0 0.9 CACNA1B "CACNL1A5, CACNN, Cav2.2" ENSG00000148408 "Calcium voltage-gated channel subunit alpha1 B" Q00975 9 137877782-138124624 "Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted membrane proteins, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel, Voltage-gated channel" "Disease variant, Epilepsy, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 10.2;pituitary gland: 6.8;testis: 5.1" "Group enriched" "Detected in some" 8 "Excitatory neurons: 388.8;Inhibitory neurons: 330.9" "Cancer enhanced" "Detected in some" "testis cancer: 2.2" "Group enriched" "Detected in many" 8 "amygdala: 5.9;basal ganglia: 7.8;cerebral cortex: 10.2;hippocampal formation: 3.5" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "SCLC-21H: 19.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022919, HPA044347" Uncertain Approved Mitochondria NA NA "Cluster 58: Brain - Synaptic function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Mitochondria "HPA022919: , HPA044347: AB_10960837" "unprognostic (1.34e-3)" "unprognostic (2.70e-2)" "unprognostic (8.08e-2)" "unprognostic (2.51e-7)" "unprognostic (8.10e-2)" "unprognostic (1.51e-2)" "unprognostic (1.33e-1)" "unprognostic (3.10e-1)" "unprognostic (2.50e-1)" "unprognostic (2.36e-2)" "unprognostic (9.73e-4)" "unprognostic (5.98e-2)" "unprognostic (6.63e-6)" "unprognostic (4.25e-2)" "unprognostic (4.72e-1)" "unprognostic (7.77e-3)" "unprognostic (8.69e-2)" 0.0 2.8 5.9 0.1 7.8 0.0 0.0 0.8 10.2 0.3 0.0 0.4 0.0 0.0 0.6 0.0 3.1 0.4 0.3 3.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.4 0.8 6.8 0.0 0.0 0.5 0.1 3.5 0.0 0.4 0.0 0.2 0.2 0.1 0.0 0.0 0.3 5.1 0.0 1.2 0.2 0.0 0.0 0.0 0.1 0.7 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.5 3.7 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.9 7.8 0.8 10.2 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 43.4 0.0 0.0 0.1 0.0 0.0 11.7 0.2 0.0 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 3.4 0.0 0.2 0.1 0.0 0.0 388.8 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 6.7 330.9 0.0 0.0 0.0 0.0 5.2 0.0 0.0 0.0 17.8 0.6 1.7 0.0 16.1 10.1 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 1.6 0.0 0.0 0.2 8.2 9.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 CACNA1E "BII, CACH6, CACNL1A6, Cav2.3" ENSG00000198216 "Calcium voltage-gated channel subunit alpha1 E" Q15878 1 181317690-181808084 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel, Voltage-gated channel" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 28 "brain: 42.8" "Cell type enhanced" "Detected in some" "Excitatory neurons: 188.7;Inhibitory neurons: 116.0;Oligodendrocyte precursor cells: 73.9;Oligodendrocytes: 34.2" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CACO-2: 1.6;NB-4: 1.0;NTERA-2: 1.1;U-266/70: 2.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042515, CAB079032" Approved Approved "Plasma membrane,Actin filaments,Cytosol" NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 29: U-266 - Adaptive immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" "Actin filaments, Cytosol" "CAB079032: , HPA042515: " "unprognostic (3.96e-3)" "unprognostic (1.89e-1)" "unprognostic (1.05e-2)" "unprognostic (1.54e-5)" "unprognostic (6.56e-2)" "unprognostic (3.16e-2)" "unprognostic (4.30e-3)" "unprognostic (1.18e-1)" "unprognostic (2.40e-1)" "unprognostic (9.48e-3)" "unprognostic (1.04e-1)" "unprognostic (2.06e-1)" "unprognostic (9.85e-7)" "unprognostic (1.74e-2)" "unprognostic (2.07e-2)" "unprognostic (1.16e-1)" "unprognostic (3.75e-2)" 0.0 1.0 33.5 0.6 30.5 1.2 0.0 0.0 34.6 0.0 0.0 0.1 0.0 0.0 1.5 0.2 0.7 0.0 0.3 42.8 3.4 1.3 0.0 0.1 0.4 4.6 6.2 0.0 0.0 0.0 0.1 0.1 0.9 0.0 0.1 0.8 0.0 0.0 0.0 0.0 0.2 0.2 9.7 0.4 0.1 1.0 3.8 0.0 0.0 0.0 0.2 0.0 0.0 1.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.1 0.0 0.0 0.0 0.0 0.4 0.5 0.0 0.9 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 33.5 30.5 0.0 34.6 42.8 3.4 4.6 6.2 0.9 9.7 3.8 1.1 0.0 0.0 0.0 3.6 0.0 0.1 0.0 0.0 0.0 4.6 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.1 0.0 0.4 0.0 0.0 188.7 0.0 0.0 0.1 0.0 0.1 0.0 0.5 0.0 0.0 0.0 0.0 116.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 6.5 0.0 0.2 0.0 73.9 34.2 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.3 0.0 0.0 0.1 0.2 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 CACNA1F "AIED, Cav1.4, CORDX3, CSNB2, CSNB2A, CSNBX2, JM8, JMC8, OA2" ENSG00000102001 "Calcium voltage-gated channel subunit alpha1 F" O60840 X 49205063-49233371 "Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Sensory transduction, Transport, Vision" "Calcium channel, Ion channel, Voltage-gated channel" "Cone-rod dystrophy, Congenital stationary night blindness, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 53 "retina: 125.3" "Group enriched" "Detected in some" 13 "Bipolar cells: 66.5;Cone photoreceptor cells: 133.5;Rod photoreceptor cells: 97.5" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Immune cell enhanced" "Detected in single" "plasmacytoid DC: 1.3" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in single" "U-266/70: 1.4" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA068379 Enhanced NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 79: Retina - Phototransduction" "Cluster 29: U-266 - Adaptive immune response" "Cluster 9: Photoreceptor cells - Phototransduction" "HPA068379: AB_2732782" "unprognostic (1.20e-3)" "unprognostic (8.62e-2)" "unprognostic (4.25e-3)" "unprognostic (1.56e-2)" "unprognostic (8.46e-2)" "unprognostic (1.84e-1)" "unprognostic (1.23e-2)" "unprognostic (1.76e-1)" "unprognostic (1.23e-1)" "unprognostic (9.04e-2)" "unprognostic (7.36e-2)" "unprognostic (1.59e-1)" "unprognostic (6.08e-7)" "unprognostic (8.03e-2)" "unprognostic (1.09e-1)" "unprognostic (4.65e-2)" "unprognostic (3.77e-3)" 0.2 0.4 0.7 0.4 0.7 1.9 0.7 2.3 1.4 0.2 0.8 0.6 0.8 0.2 1.0 0.2 0.5 0.2 0.2 0.8 0.4 0.3 0.0 0.6 1.3 0.4 0.1 0.3 0.6 0.0 0.1 0.0 0.5 0.1 0.7 125.3 0.6 0.4 0.0 1.0 1.6 0.2 0.0 0.8 0.6 0.2 0.4 0.8 0.4 0.0 0.5 0.2 0.1 0.8 0.1 0.7 0.0 0.0 0.1 0.0 0.7 0.1 0.0 0.0 0.0 0.0 0.2 0.3 0.1 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.1 0.0 0.2 0.1 0.0 0.1 0.0 0.0 0.2 0.2 0.3 0.1 0.0 0.8 0.4 0.5 0.4 0.5 0.0 0.0 0.0 0.3 0.2 0.5 0.1 0.0 0.0 0.1 0.0 0.2 0.2 0.6 0.3 0.0 0.0 0.0 0.0 1.4 0.5 0.0 0.0 0.1 0.0 0.3 0.2 0.2 0.1 0.1 0.1 0.1 0.2 0.1 0.2 0.4 0.1 0.2 0.5 0.1 0.3 1.3 0.1 0.0 0.7 0.7 2.3 1.4 0.8 0.4 0.4 0.1 0.5 0.0 0.4 0.8 0.2 0.0 0.5 0.0 1.1 0.0 0.1 0.1 0.0 66.5 1.1 0.9 1.9 0.0 0.0 1.8 133.5 0.1 2.8 0.2 0.0 0.0 0.0 0.4 0.0 1.0 0.0 0.4 0.9 0.2 0.2 0.1 1.1 0.2 0.0 0.0 0.0 0.0 0.2 6.7 0.4 2.3 0.0 0.0 1.7 0.0 0.0 0.6 0.0 0.0 0.1 7.4 0.0 0.0 0.3 0.0 0.1 0.4 0.1 0.1 0.4 0.1 0.1 97.5 0.0 0.1 0.1 0.1 0.3 0.0 0.0 0.0 0.3 0.1 0.3 0.1 CACNA1G "Cav3.1, NBR13" ENSG00000006283 "Calcium voltage-gated channel subunit alpha1 G" O43497 17 50560715-50627474 "Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted membrane proteins, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel, Voltage-gated channel" "Disease variant, FDA approved drug targets, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 37.5;cervix: 9.9" "Cell type enriched" "Detected in some" 7 "Bipolar cells: 176.7" "Cancer enhanced" "Detected in some" "glioma: 1.6;testis cancer: 1.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 9.2;GAMG: 3.2;HeLa: 3.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004714 Uncertain NA NA "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 20: HeLa - Mitochondria" "Cluster 56: Bipolar cells - Visual perception" "HPA004714: AB_1078368" "unprognostic (1.90e-2)" "unprognostic (5.83e-2)" "unprognostic (2.85e-2)" "unprognostic (1.08e-1)" "unprognostic (4.00e-1)" "unprognostic (9.89e-2)" "unprognostic (1.47e-2)" "unprognostic (2.73e-1)" "unprognostic (1.02e-4)" "unprognostic (1.47e-2)" "unprognostic (2.16e-2)" "unprognostic (9.76e-2)" "unprognostic (4.87e-12)" "unprognostic (3.34e-2)" "unprognostic (1.62e-1)" "unprognostic (1.56e-3)" "unprognostic (6.63e-2)" 1.6 0.2 7.1 0.2 5.3 0.3 1.0 19.3 9.9 9.9 0.0 0.4 0.2 2.8 0.1 0.4 3.4 0.2 3.6 2.6 10.3 0.0 0.0 0.3 0.3 4.1 19.4 5.4 0.1 0.0 0.2 0.4 1.4 1.1 0.1 8.8 0.3 0.4 0.1 1.4 0.1 0.6 12.8 0.1 0.2 0.6 37.5 0.1 0.3 0.1 0.2 0.1 3.7 6.2 0.0 9.2 2.1 2.4 0.6 0.1 0.1 0.1 0.0 0.0 0.1 1.8 0.2 0.0 0.6 0.1 3.2 0.3 1.1 0.0 0.2 1.1 0.4 0.6 3.2 0.3 0.1 0.0 0.2 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.1 0.1 0.5 0.0 0.0 0.7 0.5 0.4 1.0 0.8 0.0 0.0 0.1 2.7 1.1 1.8 0.1 0.0 1.5 0.0 0.1 0.2 0.8 2.5 0.3 0.1 0.6 0.0 0.0 0.4 0.1 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 7.1 5.3 19.3 9.9 2.6 10.3 4.1 19.4 1.4 12.8 37.5 6.2 0.2 0.0 0.0 0.3 0.0 1.9 0.2 0.0 0.6 176.7 0.3 0.5 4.5 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 1.6 0.6 11.2 0.6 0.0 0.0 16.0 0.0 0.6 4.5 0.0 0.6 0.0 0.1 0.0 0.0 0.4 5.0 21.5 0.0 0.0 0.0 5.7 0.2 0.0 0.9 3.6 1.0 0.0 2.3 0.0 22.6 0.8 0.0 0.0 0.0 0.0 0.4 0.0 0.2 0.0 5.9 0.0 0.3 3.7 0.7 0.9 0.8 2.8 0.1 0.3 0.0 0.1 0.1 CACNA1H Cav3.2 ENSG00000196557 "Calcium voltage-gated channel subunit alpha1 H" O95180 16 1153106-1221771 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel, Voltage-gated channel" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 107.7" "Cell type enhanced" "Detected in many" "Bipolar cells: 22.8;Late spermatids: 15.5;Peritubular cells: 25.9;Sertoli cells: 26.3;Smooth muscle cells: 22.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 17.9;AN3-CA: 25.4;MCF7: 48.3;OE19: 16.0;T-47d: 13.9" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA039125 Approved Approved Nucleoplasm,Vesicles NA NA "Cluster 89: Fibroblasts - ECM organization" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 48: Smooth muscle cells - ECM organization" "Nucleoplasm, Vesicles" "HPA039125: AB_10795578" "unprognostic (1.66e-3)" "unprognostic (2.10e-1)" "unprognostic (4.07e-2)" "unprognostic (1.21e-3)" "unprognostic (1.37e-2)" "unprognostic (2.15e-1)" "unprognostic (4.39e-2)" "unprognostic (2.38e-2)" "unprognostic (1.06e-1)" "unprognostic (3.30e-2)" "prognostic favorable (3.12e-5)" "unprognostic (1.66e-2)" "prognostic unfavorable (1.78e-5)" "unprognostic (1.93e-2)" "unprognostic (4.65e-2)" "unprognostic (1.70e-2)" "unprognostic (5.55e-2)" 13.6 28.0 13.6 5.2 24.5 0.1 7.6 2.1 12.1 26.3 0.0 107.7 6.4 57.3 2.6 7.1 37.8 10.3 9.3 11.0 8.1 14.1 13.4 11.8 0.7 3.0 3.8 80.1 4.6 3.6 45.9 2.1 2.9 28.0 2.4 1.8 1.9 27.5 6.2 19.4 22.3 15.6 3.7 0.7 27.5 19.4 13.5 0.5 11.0 3.0 0.2 57.0 17.1 0.2 0.0 17.9 3.0 25.4 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.0 0.0 0.0 0.1 0.8 0.0 0.0 0.0 10.4 0.1 0.0 11.0 3.0 0.0 4.5 0.3 0.0 0.0 0.0 0.0 0.0 3.0 4.9 0.0 0.0 48.3 0.0 0.0 9.4 16.0 3.6 0.0 0.0 0.2 4.7 0.0 0.0 0.0 0.0 0.0 0.9 1.0 13.9 0.0 0.0 0.0 10.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.6 24.5 2.1 12.1 11.0 8.1 3.0 3.8 2.9 3.7 13.5 0.2 1.3 0.0 0.0 1.0 0.0 1.5 0.1 0.0 0.0 22.8 0.3 0.1 2.7 4.3 0.0 0.0 0.0 0.0 0.2 0.1 0.0 3.7 7.2 0.2 5.3 2.2 10.8 0.0 2.6 0.0 0.1 1.3 0.5 0.2 4.5 0.0 0.4 7.8 0.1 0.0 0.7 1.0 2.0 0.0 0.3 15.5 8.4 0.2 0.0 0.0 0.0 0.8 0.0 0.5 0.1 0.4 0.4 25.9 0.0 7.2 0.0 0.7 0.0 1.5 26.3 0.4 22.4 3.4 5.1 0.0 3.4 0.0 0.2 0.3 0.1 1.3 CACNA2D4 ENSG00000151062 "Calcium voltage-gated channel auxiliary subunit alpha2delta 4" Q7Z3S7 12 1791963-1918666 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel, Voltage-gated channel" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 39 "retina: 20.2" "Cell type enhanced" "Detected in many" "Bipolar cells: 56.3;Cone photoreceptor cells: 156.4;Early spermatids: 56.3;Late spermatids: 117.6;Rod photoreceptor cells: 98.5" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in many" 8 "dendritic cells: 2.9;monocytes: 4.4;T-cells: 4.2" "Cell line enhanced" "Detected in some" "Hep G2: 4.7;HL-60: 2.8;HMC-1: 14.0;NB-4: 6.6" "Low region specificity" "Detected in many" "Not detected" "Not detected" HPA031952 Uncertain NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 79: Retina - Phototransduction" "Cluster 3: HMC-1 - Innate immune response" "Cluster 9: Photoreceptor cells - Phototransduction" "HPA031952: AB_10600798" "unprognostic (5.04e-2)" "unprognostic (2.82e-2)" "unprognostic (5.32e-1)" "unprognostic (7.50e-2)" "unprognostic (1.15e-1)" "unprognostic (8.18e-4)" "unprognostic (1.10e-2)" "unprognostic (1.31e-1)" "unprognostic (2.08e-1)" "unprognostic (3.30e-3)" "unprognostic (1.24e-2)" "unprognostic (1.41e-1)" "unprognostic (1.62e-5)" "unprognostic (1.11e-1)" "unprognostic (1.07e-1)" "unprognostic (2.04e-1)" "unprognostic (2.13e-1)" 0.3 0.1 0.0 0.1 0.0 0.3 0.1 0.0 0.0 0.1 0.1 0.1 0.3 0.1 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.1 0.0 0.0 0.0 0.0 0.2 0.3 0.1 0.1 0.0 20.2 0.1 0.0 0.0 0.0 0.1 0.2 0.0 0.3 0.0 0.3 0.2 0.1 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 4.7 0.2 2.8 14.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.6 0.3 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.9 0.4 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 1.8 0.0 0.0 4.4 0.0 2.1 1.7 4.2 0.0 1.0 1.5 2.9 0.0 0.5 0.3 0.1 0.4 0.5 0.1 0.6 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.2 0.0 1.7 0.0 1.9 0.7 2.4 0.9 0.4 0.1 1.2 56.3 0.7 1.0 0.9 2.8 0.8 0.0 156.4 0.1 5.5 2.4 0.0 0.8 56.3 0.2 1.2 1.5 1.2 0.4 0.8 0.4 0.2 1.8 1.1 0.2 15.2 0.8 1.4 1.2 23.7 0.0 0.4 2.1 0.0 29.2 5.7 117.6 0.9 23.2 3.6 0.0 17.3 6.9 18.6 0.0 1.8 0.3 3.4 0.4 0.8 0.2 12.2 1.3 1.1 98.5 0.0 0.3 2.3 9.0 4.9 0.4 0.6 0.1 8.6 0.6 3.4 0.3 CACNB4 EJM4 ENSG00000182389 "Calcium voltage-gated channel auxiliary subunit beta 4" O00305 2 151832771-152099167 "Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel, Voltage-gated channel" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 16.4;skin 1: 7.3" "Cell type enhanced" "Detected in many" "Excitatory neurons: 495.6;Inhibitory neurons: 470.7;Microglial cells: 136.8;Oligodendrocyte precursor cells: 155.3" "Cancer enhanced" "Detected in single" "glioma: 0.9" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 5 "neutrophil: 3.4" "Lineage enriched" "Detected in single" 5 "granulocytes: 3.4" "Cell line enhanced" "Detected in some" "Hep G2: 4.1;HMC-1: 20.2;U-937: 5.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015601 Approved NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 6: Brain - Smell perception" "Cluster 3: HMC-1 - Innate immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA015601: AB_1845873" "unprognostic (2.92e-1)" "unprognostic (1.98e-1)" "unprognostic (1.80e-1)" "unprognostic (1.29e-1)" "unprognostic (1.14e-1)" "unprognostic (1.49e-2)" "unprognostic (3.70e-1)" "unprognostic (9.42e-4)" "unprognostic (1.23e-1)" "unprognostic (1.98e-1)" "unprognostic (1.05e-3)" "unprognostic (2.02e-1)" "unprognostic (1.55e-2)" "unprognostic (7.26e-3)" "unprognostic (3.93e-2)" "unprognostic (9.55e-3)" "unprognostic (2.45e-1)" 0.7 0.7 4.6 0.4 12.0 0.7 1.5 15.2 16.4 0.4 1.3 0.3 0.4 0.4 0.6 1.4 0.3 0.9 0.3 6.2 2.3 1.4 0.1 2.0 0.3 0.2 5.6 0.3 0.4 0.4 1.8 0.9 0.3 2.0 0.5 1.8 1.7 1.9 0.1 7.3 0.3 0.5 0.3 0.4 0.6 2.3 6.8 1.1 1.4 0.2 1.0 2.0 0.5 6.8 0.0 0.0 0.7 0.6 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.9 0.0 1.9 0.0 0.1 0.3 3.2 0.0 0.2 4.1 0.0 0.2 20.2 0.2 0.1 0.4 0.0 1.7 0.0 0.8 0.0 0.5 0.1 0.0 0.2 0.3 0.5 0.1 0.6 2.0 0.2 0.6 1.1 0.5 1.3 0.7 0.0 0.0 0.0 0.1 3.3 0.8 0.0 1.8 2.0 0.6 0.4 0.3 0.0 0.0 0.4 5.9 0.1 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.0 3.4 0.0 0.0 0.6 0.0 0.1 4.6 12.0 15.2 16.4 6.2 2.3 0.2 5.6 0.3 0.3 6.8 6.8 1.1 12.8 53.3 80.6 0.8 12.4 16.3 3.5 30.7 9.9 6.8 7.2 1.3 0.0 3.8 3.7 4.2 0.1 0.3 0.3 3.9 0.5 0.9 3.0 3.0 1.3 0.0 0.0 495.6 1.5 0.0 7.9 1.1 5.4 0.0 84.1 0.7 0.0 3.4 20.2 470.7 0.0 0.0 1.2 7.5 2.1 3.4 2.4 1.8 136.8 1.2 2.3 1.0 155.3 31.2 1.0 0.1 4.5 2.0 29.0 0.1 0.9 1.2 3.4 0.0 0.6 1.2 0.7 4.1 3.2 8.2 0.0 1.1 6.6 0.1 16.3 CAD GATD4 ENSG00000084774 "Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase" P27708 2 27217369-27243943 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Pyrimidine biosynthesis" "Allosteric enzyme, Hydrolase, Ligase, Multifunctional enzyme, Transferase" "Cancer-related genes, Congenital disorder of glycosylation, Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007781, HPA065158, HPA069341" Supported Supported Cytosol NA No 260000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 18: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" Cytosol "CAB007781: AB_562057, HPA065158: , HPA069341: AB_2686125" "unprognostic (1.69e-1)" "unprognostic (7.34e-2)" "unprognostic (1.49e-1)" "unprognostic (4.71e-3)" "unprognostic (2.55e-1)" "unprognostic (1.92e-1)" "prognostic unfavorable (1.72e-11)" "unprognostic (1.25e-1)" "unprognostic (2.22e-1)" "unprognostic (2.37e-1)" "unprognostic (1.01e-1)" "unprognostic (6.11e-2)" "prognostic unfavorable (1.82e-4)" "unprognostic (6.94e-2)" "unprognostic (1.75e-1)" "unprognostic (1.14e-1)" "unprognostic (5.93e-3)" 15.0 13.5 12.7 12.4 14.1 9.0 14.9 12.7 15.5 19.8 12.2 16.5 8.5 23.8 9.9 19.2 19.3 7.7 11.6 12.3 12.8 18.0 27.8 12.3 14.9 13.8 13.5 22.3 22.3 5.9 18.7 7.5 14.5 15.2 7.8 5.0 12.3 8.8 10.3 18.7 16.1 11.9 12.7 20.1 14.0 22.2 14.2 11.6 15.8 5.9 10.5 16.9 15.8 15.2 75.2 66.4 28.9 58.4 46.1 37.6 22.9 31.0 21.4 38.3 27.0 75.7 29.2 66.4 27.4 28.5 29.6 41.4 85.7 41.1 28.5 43.8 69.2 95.2 55.0 40.0 23.0 75.7 46.2 28.8 33.1 55.7 63.0 17.8 41.6 60.6 68.3 36.0 34.2 74.8 48.7 112.0 69.7 31.3 49.7 84.0 86.5 69.5 28.6 37.6 57.9 29.1 43.3 30.5 37.4 21.3 23.9 31.3 37.7 57.7 47.5 45.5 63.5 74.0 51.8 135.2 23.3 71.7 51.0 0.0 0.8 0.4 3.1 1.5 2.5 3.4 4.4 5.2 1.9 3.1 2.8 2.8 0.5 2.7 0.9 3.4 5.9 2.0 12.7 14.1 12.7 15.5 12.3 12.8 13.8 13.5 14.5 12.7 14.2 15.2 4.2 3.2 3.9 12.7 5.3 3.7 4.3 5.0 5.7 10.6 7.1 8.6 8.3 10.0 4.7 1.8 16.7 5.9 3.9 3.9 0.0 6.1 1.5 2.9 7.9 5.1 6.6 9.7 5.6 3.7 6.6 7.0 6.1 4.3 4.5 16.9 3.3 6.6 7.7 6.7 5.7 5.8 0.0 3.0 1.9 1.9 6.2 3.6 3.6 6.5 4.7 4.1 5.2 8.5 7.4 5.9 1.9 9.8 7.3 8.0 2.5 2.0 3.5 6.8 0.0 8.2 5.2 5.6 12.1 6.2 3.4 2.2 5.1 9.7 7.5 2.2 CAMTA1 KIAA0833 ENSG00000171735 "Calmodulin binding transcription activator 1" Q9Y6Y1 1 6785454-7769706 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Transcription, Transcription regulation" Activator "Cancer-related genes, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036342, HPA036343" Approved Supported Cytosol NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 39: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 39: Non-specific - Basic cellular processes" Cytosol "HPA036342: AB_2675072, HPA036343: AB_10671839" "unprognostic (1.11e-1)" "unprognostic (6.31e-2)" "unprognostic (5.80e-2)" "unprognostic (4.14e-3)" "unprognostic (3.10e-2)" "unprognostic (1.47e-2)" "prognostic unfavorable (5.25e-4)" "unprognostic (1.08e-2)" "unprognostic (3.59e-1)" "prognostic favorable (4.10e-4)" "unprognostic (3.90e-3)" "unprognostic (8.84e-2)" "unprognostic (1.35e-3)" "unprognostic (2.17e-2)" "unprognostic (9.19e-3)" "unprognostic (1.42e-1)" "unprognostic (9.03e-3)" 37.1 43.7 56.2 23.6 55.3 26.5 38.7 63.4 75.8 33.0 29.4 71.8 52.8 40.1 81.7 37.5 36.0 30.4 114.0 55.0 68.6 68.4 70.5 36.7 27.3 69.4 66.0 35.4 26.4 43.3 35.5 26.4 68.7 47.0 48.5 68.2 50.5 50.5 101.6 26.0 41.1 42.4 61.5 30.7 45.2 44.5 66.4 31.9 52.0 104.7 33.5 56.5 35.2 60.8 67.6 37.2 101.2 51.7 51.2 77.6 28.4 71.0 54.7 75.3 63.1 45.1 83.2 55.5 54.6 75.2 50.3 40.8 53.6 73.7 106.5 41.8 57.8 62.7 85.1 89.6 83.0 48.2 43.6 52.5 50.2 54.5 83.0 64.6 85.1 77.7 44.8 73.2 87.9 65.0 64.6 130.9 70.2 85.2 43.2 42.5 90.2 123.7 103.4 38.7 104.2 83.7 50.4 74.1 113.9 72.3 40.2 59.4 50.1 53.1 44.9 55.3 45.2 55.2 74.3 153.2 79.6 107.4 30.7 80.1 74.7 70.5 25.8 48.5 28.3 48.1 39.8 32.0 73.4 41.8 32.2 28.1 15.4 26.7 37.9 77.5 45.6 46.3 56.2 55.3 63.4 75.8 55.0 68.6 69.4 66.0 68.7 61.5 66.4 60.8 142.1 54.5 48.8 314.7 74.3 309.7 340.6 306.6 169.0 106.7 231.7 283.2 565.2 101.5 135.3 191.3 252.3 69.8 44.3 198.3 418.7 180.1 166.1 84.1 80.3 155.8 130.8 81.8 346.1 206.3 144.9 134.4 63.2 99.8 55.2 205.4 106.1 239.0 106.3 158.2 479.3 185.8 223.8 95.5 254.0 137.9 76.4 122.0 238.3 117.1 172.9 112.3 38.1 330.3 227.5 184.2 234.5 128.6 87.9 486.4 251.7 750.7 117.1 156.2 138.1 91.1 233.2 151.0 211.0 158.9 282.7 88.1 68.2 137.8 186.5 413.7 CAPN1 "CANP, CANPL1, muCANP, muCL" ENSG00000014216 "Calpain 1" P07384 11 65180566-65212006 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "esophagus: 276.2" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RT4: 516.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005992 Enhanced Supported Cytosol NA NA 9100000 "Cluster 46: Basophils - DNA binding" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 15: RT4 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "HPA005992: AB_1845924" "unprognostic (2.07e-1)" "unprognostic (2.15e-1)" "unprognostic (2.69e-1)" "unprognostic (1.40e-1)" "unprognostic (4.06e-2)" "unprognostic (1.10e-1)" "unprognostic (1.91e-2)" "unprognostic (2.48e-2)" "unprognostic (7.23e-2)" "unprognostic (2.23e-2)" "prognostic unfavorable (4.30e-4)" "unprognostic (3.33e-1)" "prognostic favorable (7.06e-8)" "unprognostic (5.70e-3)" "unprognostic (1.51e-1)" "unprognostic (1.86e-1)" "unprognostic (2.98e-1)" 44.8 43.1 27.8 51.9 26.1 66.5 48.4 29.7 30.1 80.9 28.3 78.6 80.4 56.3 27.5 276.2 92.3 55.5 53.1 27.7 33.0 53.1 44.3 56.9 57.0 41.4 31.5 44.5 71.7 36.6 40.8 56.2 43.4 62.1 57.6 9.6 118.7 67.4 84.8 125.1 88.1 45.3 33.9 50.2 65.5 6.1 37.9 49.5 71.5 55.3 86.4 83.4 117.4 27.4 285.6 147.9 42.9 97.2 77.9 104.3 127.0 84.1 144.2 103.0 74.9 94.8 250.2 71.2 136.0 179.3 111.1 409.8 60.9 366.9 32.2 76.4 44.1 170.8 80.4 93.7 76.2 40.6 228.0 107.3 196.8 85.9 43.2 92.6 178.5 50.6 103.1 55.9 87.4 181.8 83.1 130.6 120.5 145.2 133.8 80.7 43.0 43.2 138.1 516.5 76.2 55.7 87.4 331.4 80.3 45.8 142.8 77.9 147.1 73.1 50.5 159.0 38.5 33.8 26.9 86.6 127.5 48.8 82.3 87.6 57.5 77.9 39.4 51.2 31.0 30.8 30.7 35.8 48.4 31.7 17.6 24.9 33.1 34.8 30.4 38.1 35.9 74.8 27.8 26.1 29.7 30.1 27.7 33.0 41.4 31.5 43.4 33.9 37.9 27.4 27.3 25.6 27.9 21.5 39.6 59.9 127.3 120.5 56.9 10.7 44.7 36.6 22.0 74.4 81.0 77.3 20.9 238.5 61.4 184.2 39.2 180.5 0.5 41.9 26.3 31.3 44.3 58.3 15.9 115.8 111.7 39.6 57.6 58.2 46.9 48.6 37.9 36.7 88.7 21.9 15.2 76.9 59.0 51.2 34.0 2.0 43.5 67.1 48.0 14.0 112.7 38.5 61.8 6.6 1.9 179.4 124.1 50.8 17.7 78.6 155.6 34.6 71.1 16.2 39.5 25.3 36.7 0.5 2.8 102.0 68.9 196.6 40.2 35.4 125.3 156.6 CAPN5 "ADNIV, HTRA3, nCL-3, VRNI" ENSG00000149260 "Calpain 5" O15484 11 77066961-77126155 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 60.7" "Cell type enhanced" "Detected in many" "Distal enterocytes: 170.3;Gastric mucus-secreting cells: 80.0;Intestinal goblet cells: 89.8;Paneth cells: 72.6;Proximal enterocytes: 75.6;Undifferentiated cells: 69.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "gdT-cell: 1.3" "Lineage enriched" "Detected in single" 4 "T-cells: 1.3" "Cell line enhanced" "Detected in many" "OE19: 106.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033237, HPA072319" Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm Cytosol "CAB033237: AB_2069673, HPA072319: AB_2686512" "unprognostic (6.81e-3)" "unprognostic (1.31e-1)" "unprognostic (3.36e-2)" "prognostic unfavorable (2.16e-6)" "unprognostic (3.47e-3)" "unprognostic (1.34e-1)" "unprognostic (1.13e-1)" "unprognostic (5.30e-2)" "unprognostic (2.52e-1)" "unprognostic (2.21e-2)" "unprognostic (5.35e-3)" "unprognostic (4.64e-1)" "unprognostic (3.17e-3)" "unprognostic (8.58e-3)" "unprognostic (3.25e-1)" "unprognostic (2.31e-2)" "unprognostic (2.30e-3)" 6.7 12.2 8.5 10.9 7.9 2.7 4.9 6.4 8.6 13.5 3.5 60.5 60.7 10.0 5.7 31.6 10.8 36.3 7.2 8.5 8.7 15.1 52.1 4.8 1.9 11.7 8.2 13.2 5.6 1.0 5.1 2.8 12.5 16.0 49.9 3.8 7.7 8.9 1.6 3.1 52.4 11.3 9.9 3.5 47.9 21.5 7.9 2.8 4.7 1.7 2.7 15.4 10.5 8.1 0.8 12.5 8.6 7.8 32.0 30.4 0.7 11.8 22.9 13.4 10.0 6.9 3.6 0.4 7.7 24.5 14.4 0.5 3.8 1.0 6.4 0.5 0.8 2.1 0.5 0.9 7.9 0.2 0.4 16.1 1.4 22.6 5.2 18.8 14.4 5.1 0.2 0.0 26.9 19.9 1.8 0.3 6.6 106.6 9.3 2.0 27.0 0.4 4.6 16.4 0.5 13.5 1.0 2.7 5.9 5.7 1.7 0.1 23.9 25.4 12.3 34.8 1.3 0.8 1.7 0.1 13.1 0.3 5.7 0.0 0.2 0.0 1.3 0.3 0.1 0.0 0.1 0.5 0.2 0.0 0.6 0.8 0.0 0.0 0.0 0.1 0.0 0.7 8.5 7.9 6.4 8.6 8.5 8.7 11.7 8.2 12.5 9.9 7.9 8.1 1.6 0.0 0.5 4.2 1.0 1.7 0.3 2.2 0.0 3.1 0.5 1.8 1.7 24.3 10.3 23.9 0.0 0.1 3.4 170.3 1.9 10.3 1.1 1.9 5.9 2.4 22.3 5.7 4.6 32.7 0.4 7.6 80.0 3.5 0.0 10.2 2.9 40.4 0.9 1.7 6.7 89.8 10.2 1.6 1.8 1.3 12.5 1.2 7.2 1.0 0.3 5.8 5.2 11.6 0.7 22.4 72.6 4.5 0.9 2.0 75.6 9.9 11.1 2.1 0.0 8.3 4.1 0.5 2.3 2.5 0.9 0.0 1.5 5.3 69.2 2.4 CASR "FHH, GPRC2A, HHC, HHC1, NSHPT" ENSG00000036828 "Calcium sensing receptor" P41180 3 122183668-122291629 "Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Plasma proteins, Predicted membrane proteins, Transporters" "G-protein coupled receptor, Receptor, Transducer" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 29 "parathyroid gland: 654.4" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 25.6;Alveolar cells type 2: 20.2;Cholangiocytes: 27.1;Distal tubular cells: 13.7;Enteroendocrine cells: 11.5;Granulosa cells: 20.7;Respiratory ciliated cells: 15.3" "Cancer enriched" "Detected in some" 7 "pancreatic cancer: 5.5" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected" "Not detected" "HPA039686, HPA050335" Enhanced NA NA "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 40: Granulosa cells - Unknown function" "HPA039686: AB_10673536, HPA050335: AB_2681092" "unprognostic (1.97e-2)" "unprognostic (7.40e-2)" "unprognostic (8.20e-4)" "unprognostic (3.15e-1)" "unprognostic (8.55e-4)" "unprognostic (1.58e-1)" "unprognostic (7.32e-2)" "unprognostic (7.67e-2)" "unprognostic (1.62e-1)" "unprognostic (1.48e-1)" "unprognostic (1.91e-5)" "unprognostic (2.72e-1)" "unprognostic (2.26e-1)" "unprognostic (1.24e-2)" 0.1 0.1 1.5 0.1 1.0 0.8 0.0 1.7 1.6 0.0 0.3 0.1 0.8 0.0 0.1 0.0 0.1 4.2 0.0 1.0 0.6 22.4 0.2 0.0 0.2 0.6 1.1 0.5 9.6 654.4 0.2 0.0 0.8 0.1 0.2 1.5 0.1 0.0 0.1 0.2 0.5 0.0 0.2 0.1 2.8 0.2 1.7 0.1 0.7 0.0 0.2 0.3 0.0 1.7 0.1 0.2 0.1 0.2 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.2 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.3 0.2 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.1 0.3 0.0 0.1 0.1 0.1 0.3 0.1 0.1 0.1 0.1 0.1 0.8 0.3 0.1 0.1 0.2 0.1 0.0 0.3 0.2 0.0 0.2 0.2 0.3 0.2 0.0 0.3 0.2 0.1 0.1 0.1 0.2 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 1.5 1.0 1.7 1.6 1.0 0.6 0.6 1.1 0.8 0.2 1.7 1.7 0.0 25.6 20.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 27.1 5.6 3.7 0.0 0.0 0.0 0.0 13.7 4.3 0.5 0.0 0.0 0.5 11.5 0.0 0.3 0.2 0.0 1.6 0.0 0.0 1.3 20.7 0.0 0.1 0.1 0.0 0.1 0.6 0.0 1.0 0.0 1.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.1 0.4 0.0 0.0 0.0 0.2 15.3 1.0 0.0 0.0 1.5 0.0 0.5 0.0 0.0 0.0 0.9 0.8 0.0 0.0 CCDC50 "C3orf6, DFNA44, Ymer" ENSG00000152492 "Coiled-coil domain containing 50" Q8IVM0 3 191329085-191398659 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "dendritic cells: 363.7;Oligodendrocyte precursor cells: 365.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "plasmacytoid DC: 630.7" "Lineage enriched" "Detected in all" 5 "dendritic cells: 630.7" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001336 Approved Supported Cytosol NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 65: Plasmacytoid DCs - Unknown function" Cytosol "HPA001336: AB_1078421" "unprognostic (5.01e-2)" "unprognostic (1.44e-1)" "unprognostic (7.84e-2)" "unprognostic (8.77e-3)" "unprognostic (1.73e-2)" "unprognostic (8.29e-2)" "prognostic unfavorable (2.48e-5)" "unprognostic (3.03e-2)" "unprognostic (2.51e-2)" "unprognostic (4.48e-2)" "unprognostic (3.17e-3)" "unprognostic (2.05e-2)" "unprognostic (7.79e-2)" "unprognostic (1.01e-1)" "unprognostic (6.19e-2)" "unprognostic (7.57e-2)" "unprognostic (4.19e-1)" 63.2 28.3 19.6 34.3 20.7 10.3 30.6 21.5 19.1 24.1 18.8 26.9 24.2 33.0 24.8 27.9 24.3 34.8 39.7 17.6 23.3 32.4 56.5 31.6 42.2 24.1 22.0 46.2 35.1 27.6 13.5 34.9 24.1 26.2 25.4 11.8 23.7 33.3 19.0 18.4 25.8 48.1 23.2 45.0 24.3 29.6 21.3 17.7 27.4 26.1 41.0 36.7 18.6 24.7 74.9 24.5 93.6 24.7 82.3 72.1 32.3 135.4 135.2 95.4 95.0 52.6 28.9 14.6 163.0 76.8 70.6 83.6 75.6 60.5 141.9 109.0 37.8 10.0 31.7 60.3 120.8 36.8 37.8 58.2 79.3 75.6 169.7 82.2 148.7 0.0 33.9 77.3 85.4 26.0 0.2 23.1 33.2 7.6 103.0 56.3 51.9 73.1 104.3 31.9 21.8 33.2 48.2 51.6 95.8 67.3 35.6 32.9 153.3 93.4 78.4 68.4 176.3 118.6 54.9 0.9 50.5 0.1 76.9 0.1 22.1 2.1 5.9 20.8 2.4 128.5 6.1 3.9 44.3 76.5 1.3 1.5 2.2 24.0 12.1 630.7 22.1 18.0 19.6 20.7 21.5 19.1 17.6 23.3 24.1 22.0 24.1 23.2 21.3 24.7 143.5 25.6 54.5 40.5 134.5 46.9 52.5 30.7 30.7 27.2 32.5 37.5 48.4 58.6 34.7 51.5 27.1 28.1 363.7 44.1 31.3 120.4 183.0 97.3 58.1 134.0 22.8 11.2 15.8 78.5 36.3 66.6 41.8 79.0 2.5 58.5 175.6 79.5 84.4 25.2 41.3 33.8 38.7 59.4 78.3 92.1 69.3 61.4 53.4 98.4 101.4 32.1 5.2 365.4 28.9 174.7 33.9 75.6 102.7 69.8 37.6 71.8 26.3 14.4 59.2 74.1 65.7 73.2 26.6 24.0 32.5 33.5 22.4 49.5 33.7 62.4 CCDC88A "APE, FLJ10392, GIV, GRDN, HkRP1, KIAA1212" ENSG00000115355 "Coiled-coil domain containing 88A" Q3V6T2 2 55287842-55419895 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cilium biogenesis/degradation, DNA replication, Neurogenesis" "Guanine-nucleotide releasing factor" "Epilepsy, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 80.9" "Cell type enhanced" "Detected in many" "Early spermatids: 634.4;Late spermatids: 699.8;Oligodendrocytes: 754.9;Spermatocytes: 429.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "basophil: 7.4;classical monocyte: 7.2;intermediate monocyte: 7.0;myeloid DC: 11.3;non-classical monocyte: 6.8;plasmacytoid DC: 23.9" "Group enriched" "Detected in all" 7 "dendritic cells: 23.9;granulocytes: 7.4;monocytes: 7.2" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038101, HPA038102" Enhanced NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA038101: AB_10670654, HPA038102: AB_2675833" "unprognostic (1.20e-1)" "unprognostic (2.86e-1)" "unprognostic (1.19e-1)" "prognostic unfavorable (2.06e-4)" "unprognostic (1.91e-2)" "unprognostic (2.88e-1)" "prognostic unfavorable (4.86e-4)" "unprognostic (8.51e-2)" "unprognostic (1.59e-1)" "unprognostic (1.35e-1)" "unprognostic (3.18e-3)" "unprognostic (1.71e-1)" "prognostic unfavorable (5.98e-8)" "unprognostic (1.42e-2)" "unprognostic (2.61e-1)" "unprognostic (5.74e-3)" "unprognostic (8.96e-3)" 11.4 9.7 48.4 14.0 65.3 15.6 8.4 53.2 77.6 8.7 29.6 9.6 3.8 9.8 3.3 5.4 7.5 7.7 9.2 48.8 54.4 4.7 8.4 14.5 17.2 54.8 60.8 9.3 10.7 3.4 13.2 8.3 57.7 5.9 5.2 26.3 6.7 5.4 7.3 4.2 7.1 9.3 48.8 13.3 6.5 47.3 62.6 18.8 5.8 9.6 15.1 9.6 6.2 80.9 22.8 19.7 45.2 18.3 29.4 24.3 4.0 32.3 30.1 18.9 20.6 2.1 12.0 60.2 19.5 32.6 28.9 0.4 28.9 19.3 46.8 69.8 16.8 41.4 21.7 28.6 12.6 70.7 26.8 15.8 3.8 44.6 28.6 27.1 50.3 48.1 44.9 95.9 51.9 0.2 33.5 41.1 37.4 0.3 24.8 39.7 71.1 0.3 22.9 12.1 23.5 34.8 57.4 0.1 28.9 26.2 1.1 20.2 34.9 54.4 36.5 36.6 39.6 28.8 24.0 25.8 38.0 56.2 23.7 7.4 7.2 2.1 1.4 7.0 0.8 1.8 0.6 1.1 11.3 0.6 0.7 0.6 0.6 1.2 6.8 23.9 0.3 2.1 48.4 65.3 53.2 77.6 48.8 54.4 54.8 60.8 57.7 48.8 62.6 80.9 35.6 12.8 27.9 197.9 25.5 8.4 7.4 11.2 9.1 225.1 7.2 11.9 52.8 4.3 12.8 5.5 37.5 6.5 90.5 0.2 1.9 4.2 634.4 8.0 58.8 41.0 10.8 51.3 317.1 16.8 18.4 38.1 9.2 3.1 152.8 64.4 22.1 18.5 110.8 79.1 318.9 0.0 4.1 142.0 126.7 699.8 29.8 184.2 16.0 129.3 236.1 109.8 11.3 296.6 754.9 31.1 0.2 28.6 114.7 2.9 0.0 8.1 10.1 61.9 32.9 45.1 55.4 429.0 95.5 5.9 6.5 2.3 22.4 82.3 0.1 2.8 CCDC88C "DAPLE, HkRP2, KIAA1509, SCA40" ENSG00000015133 "Coiled-coil domain containing 88C" Q9P219 14 91271323-91417844 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Wnt signaling pathway" "Guanine-nucleotide releasing factor" "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 33.9" "Cell type enhanced" "Detected in many" "dendritic cells: 80.1;NK-cells: 142.2;Plasma cells: 93.2;Respiratory ciliated cells: 112.5;T-cells: 89.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "JURKAT: 55.6;Karpas-707: 50.1;SCLC-21H: 53.6;U-266/70: 58.5;U-266/84: 76.2" "Low region specificity" "Detected in all" "Region enriched" "Detected in many" 5 "basal ganglia: 37.0" HPA005832 Approved Approved "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 16: U-266 - Nucleosome" "Cluster 63: NK-cells & T-cells - Immune response" "Nucleoplasm, Nucleoli fibrillar center" "HPA005832: AB_1079202" "unprognostic (7.28e-2)" "unprognostic (2.33e-3)" "unprognostic (7.23e-2)" "unprognostic (5.06e-2)" "unprognostic (1.00e-1)" "prognostic favorable (3.47e-4)" "unprognostic (3.07e-2)" "prognostic favorable (2.90e-4)" "unprognostic (1.48e-1)" "unprognostic (2.13e-1)" "unprognostic (4.77e-2)" "unprognostic (1.03e-1)" "prognostic unfavorable (2.80e-4)" "unprognostic (7.48e-2)" "unprognostic (2.22e-1)" "unprognostic (2.15e-2)" "unprognostic (4.35e-2)" 4.5 1.4 5.9 19.4 23.9 31.2 6.9 3.2 7.1 4.0 2.5 9.4 13.3 3.1 1.6 12.5 12.2 6.2 4.0 3.6 3.9 6.8 3.6 9.7 33.9 5.6 6.7 1.0 8.3 5.3 5.2 2.4 4.6 9.4 7.0 1.0 10.1 3.9 2.3 7.0 11.7 2.3 4.3 21.7 12.4 8.0 7.8 20.4 2.5 2.7 20.4 8.1 7.6 3.2 8.5 6.9 7.5 9.5 0.0 0.0 34.9 0.0 0.0 0.0 0.0 6.8 13.4 45.1 6.1 0.0 0.4 0.4 11.3 6.4 0.0 28.8 4.7 10.0 4.8 9.9 0.7 23.0 8.4 0.0 11.4 0.0 0.0 0.7 8.6 55.6 11.2 50.1 0.1 24.9 24.2 29.6 7.1 6.2 11.5 19.5 0.2 14.2 2.6 10.2 53.6 11.6 4.6 16.9 4.6 5.6 10.2 20.7 2.6 0.0 0.2 0.1 0.1 58.5 76.2 22.8 0.0 20.1 0.1 7.8 3.3 1.3 9.4 1.9 8.8 2.5 6.0 9.2 1.8 2.1 3.8 5.8 2.3 4.0 3.0 2.0 10.7 4.1 5.9 23.9 3.2 7.1 3.6 3.9 5.6 6.7 4.6 4.3 7.8 3.2 26.6 3.2 28.8 7.8 54.1 9.3 15.9 19.0 27.9 0.0 15.3 7.6 19.8 10.0 22.1 14.7 0.0 3.6 80.1 29.6 0.0 4.4 9.6 62.6 1.4 17.3 23.9 20.6 7.1 5.9 2.2 4.2 20.4 12.1 2.5 1.3 20.3 1.6 6.3 0.0 2.5 15.3 22.4 21.0 12.4 18.7 4.1 18.9 1.8 9.4 20.1 8.0 142.2 8.0 5.2 7.8 18.2 3.0 93.2 16.8 13.1 13.2 112.5 0.1 0.0 2.9 4.4 4.7 17.4 31.2 9.5 1.8 89.2 3.3 19.4 19.8 CCT5 KIAA0098 ENSG00000150753 "Chaperonin containing TCP1 subunit 5" P48643 5 10249929-10266389 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" Chaperone "Disease variant, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002238, HPA005958, CAB006271" Enhanced NA NA 1400000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 20: HeLa - Mitochondria" "Cluster 10: Non-specific - Unknown function" "CAB006271: AB_425898, HPA002238: AB_1078427, HPA005958: AB_1846209" "unprognostic (7.02e-3)" "unprognostic (1.08e-1)" "unprognostic (1.98e-1)" "unprognostic (1.79e-2)" "unprognostic (3.46e-1)" "unprognostic (2.10e-3)" "prognostic unfavorable (6.57e-11)" "unprognostic (6.40e-3)" "unprognostic (2.04e-1)" "unprognostic (1.91e-3)" "unprognostic (1.13e-2)" "unprognostic (1.30e-2)" "prognostic unfavorable (8.23e-6)" "unprognostic (1.02e-1)" "unprognostic (1.94e-1)" "unprognostic (3.84e-1)" "unprognostic (1.82e-2)" 85.3 79.5 68.6 95.3 70.4 82.0 74.7 73.2 112.4 58.2 79.2 85.7 67.5 66.8 53.3 100.8 77.4 48.1 74.8 72.7 82.4 76.0 74.1 58.7 96.3 71.5 74.7 50.8 58.4 175.6 46.1 85.8 78.7 52.3 97.2 48.9 60.3 52.9 128.2 60.5 62.2 89.5 74.5 62.3 62.6 104.3 76.0 106.6 63.2 90.8 118.4 105.8 63.7 83.8 350.5 489.8 405.1 463.7 250.9 188.5 568.4 454.1 288.6 704.0 492.6 657.8 372.2 537.6 490.4 326.4 615.9 332.8 770.4 492.7 774.2 504.5 527.9 440.2 1063.7 510.7 293.8 667.6 303.7 221.3 300.3 556.8 368.9 191.4 422.7 343.6 597.5 188.2 453.3 494.0 481.4 659.7 432.6 348.3 579.4 437.9 304.4 275.8 447.3 359.1 304.8 335.3 953.5 424.6 335.6 316.9 327.2 490.9 285.2 576.4 517.7 214.1 687.9 192.2 322.7 570.1 323.7 955.4 470.8 125.6 181.5 139.3 117.5 248.8 155.7 151.6 131.3 130.7 188.9 125.6 121.8 123.7 101.4 147.3 286.1 69.5 150.3 255.3 68.6 70.4 73.2 112.4 72.7 82.4 71.5 74.7 78.7 74.5 76.0 83.8 81.7 67.3 41.3 12.1 71.5 88.2 172.1 206.6 60.3 46.7 50.7 54.6 23.6 51.5 116.7 49.7 18.8 214.2 60.7 81.4 49.0 217.4 235.1 127.0 107.5 92.8 70.9 98.2 16.8 162.8 271.8 81.8 62.7 101.1 48.8 100.7 40.0 52.5 175.7 35.3 19.3 89.9 116.0 69.2 64.7 93.1 83.0 84.0 40.9 13.1 92.1 56.6 72.1 19.1 22.9 199.0 81.8 75.6 59.6 128.5 61.0 99.2 131.7 60.8 72.3 81.0 272.5 282.3 184.4 93.1 74.6 155.4 66.5 170.2 126.9 126.1 CD164 "DFNA66, MGC-24, MUC-24" ENSG00000135535 "CD164 molecule" Q04900 6 109366514-109382467 "CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion, Myogenesis" "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA010636 Uncertain "Intracellular and membrane" NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 3: HMC-1 - Innate immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA010636: AB_1078447" "unprognostic (1.23e-2)" "unprognostic (1.61e-2)" "unprognostic (3.89e-2)" "unprognostic (2.21e-1)" "unprognostic (1.47e-1)" "unprognostic (1.04e-2)" "unprognostic (1.97e-3)" "unprognostic (1.80e-1)" "unprognostic (1.30e-1)" "unprognostic (1.09e-1)" "unprognostic (8.88e-2)" "unprognostic (1.38e-1)" "unprognostic (7.11e-2)" "unprognostic (1.29e-1)" "unprognostic (1.84e-1)" "unprognostic (3.01e-1)" "unprognostic (1.51e-1)" 260.9 123.6 43.6 119.1 53.6 213.9 211.2 57.4 69.5 151.0 68.9 264.8 252.0 117.0 161.9 95.0 124.8 159.3 91.8 40.6 57.7 298.1 256.8 121.9 137.8 65.3 56.1 126.4 124.1 219.2 89.5 190.1 64.1 146.1 270.5 36.4 303.8 112.7 96.0 89.2 277.6 116.1 52.3 121.0 272.8 113.6 50.7 132.0 360.4 91.7 122.9 154.2 76.0 70.7 130.0 73.0 34.6 242.9 503.0 496.6 235.7 230.8 304.0 213.7 308.0 148.1 194.9 105.7 218.0 261.5 198.0 125.4 136.9 152.7 315.4 220.1 144.5 177.8 72.0 173.9 294.9 209.5 399.0 384.6 279.7 211.3 186.5 270.3 196.9 86.9 178.9 279.9 287.8 141.1 191.5 251.2 52.9 273.1 119.6 126.3 109.0 135.1 292.2 180.5 40.2 80.9 144.6 184.0 348.6 168.0 167.7 265.0 205.6 138.8 99.1 199.5 188.6 96.3 147.4 121.2 244.0 242.8 147.2 349.0 192.3 167.0 166.8 198.6 175.0 126.2 135.2 155.1 189.7 111.0 138.0 150.1 128.5 255.2 197.5 214.1 192.9 413.8 43.6 53.6 57.4 69.5 40.6 57.7 65.3 56.1 64.1 52.3 50.7 70.7 76.5 163.5 78.9 22.5 168.1 200.1 180.2 149.6 128.7 33.8 251.1 123.3 70.9 174.5 153.5 281.4 25.0 244.9 372.7 600.0 93.9 178.8 103.8 111.9 109.2 89.2 166.5 92.8 22.1 136.8 407.2 176.3 175.8 151.2 128.6 76.7 98.2 177.4 311.9 33.7 16.4 427.3 215.7 360.4 223.9 97.3 158.8 237.3 247.3 38.4 147.1 113.3 266.8 15.6 83.1 177.6 430.0 182.1 173.6 230.3 425.5 348.0 351.2 44.4 124.9 110.0 138.1 160.5 184.4 143.0 231.0 674.5 165.9 87.7 285.0 334.7 CDC14A "cdc14, Cdc14A1, Cdc14A2, DFNB105, DFNB32" ENSG00000079335 "Cell division cycle 14A" Q9UNH5 1 100345001-100520277 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Hearing" "Hydrolase, Protein phosphatase" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 28.2" "Cell type enhanced" "Detected in many" "Astrocytes: 145.9;Early spermatids: 171.5;Late spermatids: 191.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "K-562: 44.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA023783 Approved Supported "Nucleoplasm,Nuclear bodies,Cytosol" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 23: Testis - Cell cycle regulation" "Cluster 1: K-562 - Erythropoiesis" "Cluster 34: Spermatids - Unknown function" Nucleoplasm "Nuclear bodies, Cytosol" "HPA023783: AB_1846352" "unprognostic (3.72e-2)" "unprognostic (2.38e-2)" "unprognostic (1.84e-2)" "unprognostic (2.98e-2)" "unprognostic (1.54e-3)" "unprognostic (1.38e-1)" "unprognostic (9.27e-4)" "unprognostic (4.88e-3)" "unprognostic (6.30e-2)" "unprognostic (3.97e-3)" "unprognostic (8.83e-2)" "unprognostic (1.23e-1)" "unprognostic (1.79e-3)" "unprognostic (6.29e-2)" "unprognostic (2.04e-1)" "unprognostic (1.49e-2)" "unprognostic (6.66e-2)" 3.6 1.5 3.9 4.6 3.1 15.5 11.3 2.7 4.2 5.4 5.2 6.0 7.3 5.3 2.7 2.2 13.0 3.3 2.3 3.7 4.5 6.3 1.8 5.9 7.2 4.3 4.9 4.6 2.0 6.0 3.6 5.1 3.3 7.6 6.0 5.5 3.4 3.0 2.6 3.8 10.7 4.7 3.5 6.7 5.8 28.2 3.6 6.4 5.8 2.8 4.4 4.4 3.3 3.2 3.3 2.6 8.1 9.3 2.9 2.1 5.7 4.1 2.7 3.9 3.1 8.9 2.7 1.6 3.0 2.4 3.2 2.5 5.6 2.3 4.0 3.4 13.7 5.8 2.3 2.9 1.1 7.8 9.8 1.8 0.6 4.3 1.4 2.0 7.0 3.3 44.7 4.8 5.8 1.4 6.3 8.7 5.1 2.1 3.3 6.8 10.6 1.7 2.8 7.2 1.5 2.7 4.3 4.1 5.6 3.9 1.9 10.0 3.1 2.2 4.9 3.8 2.5 2.4 0.9 2.5 2.7 7.3 1.3 12.2 3.6 9.0 6.9 3.3 12.5 4.5 10.9 8.2 3.5 2.9 10.2 5.5 5.4 4.4 2.3 6.2 6.0 4.1 3.9 3.1 2.7 4.2 3.7 4.5 4.3 4.9 3.3 3.5 3.6 3.2 14.1 3.2 5.5 145.9 10.6 3.7 4.5 1.7 4.6 0.4 15.8 11.0 6.6 0.0 4.4 1.8 4.2 2.7 23.2 18.4 0.0 3.0 171.5 48.3 11.8 13.5 4.8 3.8 4.3 1.9 1.0 7.0 6.6 51.1 15.2 4.8 7.1 1.0 2.8 0.0 1.4 4.0 2.0 5.5 7.3 191.7 5.0 11.1 5.4 51.5 9.3 11.4 6.2 53.8 3.6 3.1 11.2 0.7 13.5 5.2 22.9 2.5 22.5 3.8 0.0 6.2 6.0 2.3 3.6 4.9 2.4 2.2 44.1 3.0 3.7 4.1 CDH23 "CDHR23, DFNB12, USH1D" ENSG00000107736 "Cadherin related 23" Q9H251 10 71396920-71815947 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion, Hearing, Sensory transduction, Vision" "Deafness, Disease variant, Non-syndromic deafness, Retinitis pigmentosa, Usher syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 35.6;ovary: 35.3" "Cell type enhanced" "Detected in many" "Early spermatids: 78.4;Late spermatids: 67.7;Microglial cells: 33.7;Muller glia cells: 90.7" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "intermediate monocyte: 26.8;non-classical monocyte: 38.1;plasmacytoid DC: 9.5" "Lineage enhanced" "Detected in many" "monocytes: 38.1" "Group enriched" "Detected in some" 4 "RT4: 13.4;SCLC-21H: 5.3" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA017232 Approved NA NA 950000 "Cluster 51: Monocytes - Innate immune response" "Cluster 21: Non-specific - Transcription" "Cluster 15: RT4 - Unknown function" "Cluster 5: Muller glia cells - Visual perception" "HPA017232: AB_1845903" "unprognostic (6.76e-2)" "unprognostic (2.86e-3)" "unprognostic (3.82e-2)" "unprognostic (3.13e-3)" "unprognostic (1.07e-1)" "unprognostic (5.52e-2)" "unprognostic (7.93e-2)" "unprognostic (2.88e-1)" "unprognostic (6.44e-3)" "unprognostic (4.67e-2)" "unprognostic (2.05e-1)" "unprognostic (9.23e-3)" "unprognostic (2.14e-3)" "unprognostic (2.33e-2)" "unprognostic (1.72e-1)" "unprognostic (1.70e-2)" "prognostic favorable (3.40e-4)" 11.3 3.3 9.6 2.1 11.6 2.2 6.2 10.6 7.9 3.3 10.2 1.7 1.1 4.9 1.6 1.8 8.9 2.2 5.4 6.3 16.2 0.9 14.4 7.8 1.7 35.6 18.5 35.3 8.4 9.9 1.2 0.5 34.7 3.7 1.2 14.4 1.2 0.7 2.7 1.6 2.3 2.1 8.6 7.0 1.7 11.0 23.6 5.3 1.8 2.5 1.4 4.2 2.6 8.8 0.0 0.7 0.8 1.3 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.3 0.1 0.1 0.1 0.0 0.9 0.4 1.3 0.0 0.0 0.1 1.2 1.3 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.1 0.0 0.0 0.2 0.1 1.5 0.4 0.0 1.1 0.0 0.1 0.0 13.4 5.3 1.1 0.8 0.2 0.1 1.1 0.1 2.2 0.0 0.0 1.1 0.0 0.0 0.6 0.0 0.2 1.5 1.0 0.0 0.0 6.0 5.1 0.1 26.8 0.4 0.0 0.2 0.1 4.9 0.0 0.2 0.6 6.1 0.0 38.1 9.5 0.0 2.9 9.6 11.6 10.6 7.9 6.3 16.2 35.6 18.5 34.7 8.6 23.6 8.8 8.2 0.0 0.6 9.4 1.1 0.8 4.1 0.3 0.6 1.9 0.2 1.1 4.7 0.0 1.0 1.8 0.0 1.5 11.5 0.9 0.0 0.4 78.4 1.9 0.7 10.0 7.2 0.0 1.1 0.4 4.4 3.4 1.1 0.3 0.0 0.4 7.9 20.4 2.2 0.0 2.7 1.1 0.0 12.2 11.6 67.7 2.5 15.0 7.2 33.7 10.6 90.7 3.1 1.5 8.5 0.2 7.5 0.7 0.4 2.6 1.6 0.8 0.7 4.2 6.6 5.1 1.7 3.4 1.0 0.0 1.1 0.3 1.0 0.2 0.7 3.6 CDHR1 "CORD15, KIAA1775, PCDH21, RP65" ENSG00000148600 "Cadherin related family member 1" Q96JP9 10 84194537-84219621 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion" Receptor "Cone-rod dystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "retina: 313.8;skin 1: 214.0" "Group enriched" "Detected in many" 4 "Cone photoreceptor cells: 379.5;Rod photoreceptor cells: 240.4" "Cancer enhanced" "Detected in many" "colorectal cancer: 13.8" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 12 "NK-cell: 7.5" "Lineage enriched" "Detected in single" 12 "NK-cells: 7.5" "Cell line enhanced" "Detected in some" "HAP1: 10.2;HEK 293: 5.2;HEL: 6.3;K-562: 4.6;NTERA-2: 4.4;RPTEC TERT1: 16.3" "Region enriched" "Detected in many" 21 "olfactory bulb: 333.0" "Low region specificity" "Detected in all" HPA036819 Enhanced "Intracellular and membrane" NA NA 55000 "Cluster 15: NK-cells - Transcription" "Cluster 77: Retina - Visual perception" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 9: Photoreceptor cells - Phototransduction" "HPA036819: AB_10671750" "unprognostic (8.91e-4)" "unprognostic (5.60e-2)" "unprognostic (1.64e-1)" "unprognostic (2.71e-2)" "unprognostic (2.63e-2)" "unprognostic (3.03e-2)" "unprognostic (6.40e-2)" "unprognostic (7.77e-2)" "unprognostic (1.41e-1)" "unprognostic (2.67e-1)" "unprognostic (6.69e-4)" "unprognostic (1.90e-1)" "unprognostic (5.51e-3)" "unprognostic (1.26e-1)" "unprognostic (2.27e-1)" "unprognostic (4.56e-3)" "unprognostic (5.07e-2)" 0.2 1.9 7.4 1.0 18.3 0.4 4.5 2.3 8.7 5.3 46.2 29.2 0.1 0.6 4.4 10.7 0.5 0.4 1.2 6.6 7.5 0.4 0.5 0.2 0.9 13.4 2.3 1.1 0.1 0.0 3.0 0.2 13.9 1.4 53.2 313.8 1.5 4.2 1.0 214.0 12.2 1.2 0.1 7.0 0.2 0.3 3.2 3.3 0.2 0.0 1.1 0.1 3.5 3.5 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 10.2 2.0 0.0 0.0 5.2 6.3 0.0 0.0 0.2 0.0 0.2 0.0 2.2 0.0 0.7 0.0 0.0 0.0 4.6 0.0 0.0 0.0 0.0 1.5 4.4 0.0 0.0 0.0 0.0 1.4 16.3 0.0 3.4 0.8 0.0 0.0 0.0 2.5 0.0 0.2 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.6 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 7.5 0.0 0.0 0.0 0.1 7.4 18.3 2.3 8.7 6.6 7.5 13.4 2.3 13.9 0.1 3.2 3.5 0.0 0.0 0.5 1.3 0.1 51.2 0.3 1.4 3.4 24.1 0.0 0.1 1.8 0.0 0.7 0.0 379.5 0.0 2.1 47.9 0.0 0.1 0.0 2.7 0.7 1.8 12.7 0.0 4.9 0.0 0.0 0.6 0.0 3.1 0.0 3.7 0.4 0.4 0.0 5.0 7.7 46.9 0.0 0.3 5.2 0.2 0.0 0.1 3.6 1.0 0.0 26.3 1.0 7.5 4.4 0.0 31.2 0.0 0.7 0.3 23.0 0.2 0.1 240.4 0.0 0.2 0.3 0.6 0.3 3.0 67.5 0.0 3.0 0.3 52.9 0.2 CDK19 "bA346C16.3, CDC2L6, CDK11, KIAA1028" ENSG00000155111 "Cyclin dependent kinase 19" Q9BWU1 6 110609978-110815958 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 40.8" "Cell type enhanced" "Detected in all" "Late spermatids: 137.1;Oligodendrocyte precursor cells: 154.8;Oligodendrocytes: 476.3" "Cancer enhanced" "Detected in all" "prostate cancer: 23.3" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 4.6" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007053, HPA007062" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 18: U-2197 - ECM organization" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol Nucleoplasm "HPA007053: AB_1233803, HPA007062: " "unprognostic (1.66e-2)" "unprognostic (1.84e-1)" "unprognostic (3.63e-1)" "unprognostic (3.00e-3)" "unprognostic (1.62e-1)" "unprognostic (2.66e-3)" "prognostic unfavorable (3.56e-4)" "unprognostic (1.47e-2)" "unprognostic (2.96e-2)" "unprognostic (2.00e-3)" "unprognostic (3.94e-1)" "unprognostic (4.04e-1)" "prognostic unfavorable (4.72e-5)" "unprognostic (1.75e-1)" "unprognostic (9.78e-2)" "unprognostic (6.51e-2)" "unprognostic (9.50e-3)" 6.2 3.4 22.7 7.2 32.1 11.7 6.4 17.9 29.0 6.6 7.5 6.9 5.3 10.2 3.8 8.2 5.4 8.3 4.4 20.8 19.3 6.4 5.0 6.7 9.4 28.8 24.7 9.8 3.9 6.5 2.3 11.5 22.7 26.7 6.4 8.8 4.4 5.9 3.3 8.5 6.7 7.3 19.4 8.0 7.1 18.5 26.9 13.6 6.1 5.4 9.2 5.3 6.6 40.8 5.7 6.1 21.8 26.4 11.1 15.6 10.8 18.8 19.4 6.7 8.8 7.6 6.4 14.7 6.5 13.2 13.9 3.2 8.0 3.9 15.4 18.2 4.5 26.0 8.8 8.9 6.8 10.5 18.2 10.7 8.6 9.7 14.1 17.0 6.8 12.3 7.6 20.2 14.5 9.7 14.3 15.0 2.0 8.1 4.1 14.8 11.3 5.8 7.8 11.0 10.6 19.8 14.4 11.3 17.0 7.2 3.9 37.1 7.7 14.2 7.6 29.6 11.4 2.1 3.2 12.8 15.6 13.7 14.9 2.1 1.2 0.9 0.4 0.7 0.4 0.6 0.3 0.3 1.0 0.6 0.2 0.3 4.6 0.7 0.4 0.5 0.4 0.3 22.7 32.1 17.9 29.0 20.8 19.3 28.8 24.7 22.7 19.4 26.9 40.8 15.9 3.2 17.8 50.6 19.2 9.8 14.4 6.7 12.0 19.2 14.6 9.4 8.2 18.6 8.7 16.5 16.7 7.0 17.8 27.0 1.9 10.5 102.3 13.7 16.5 13.6 12.6 21.6 85.3 4.7 18.4 12.0 13.7 25.6 7.0 23.0 20.0 12.2 16.4 23.5 51.5 13.5 8.2 33.9 19.9 137.1 10.8 22.1 26.6 62.8 19.6 33.9 22.6 154.8 476.3 7.0 20.0 16.1 5.9 30.0 16.1 7.7 6.9 13.9 6.6 11.2 12.3 56.6 15.8 20.3 16.2 7.9 13.3 10.1 13.8 11.1 CDKL5 "CFAP247, EIEE2, STK9" ENSG00000008086 "Cyclin dependent kinase like 5" O76039 X 18425583-18653629 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 216.6;Horizontal cells: 80.8;Inhibitory neurons: 116.1;Oligodendrocytes: 79.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "basophil: 5.7" "Lineage enriched" "Detected in single" 11 "granulocytes: 5.7" "Cell line enhanced" "Detected in many" "A549: 10.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002847, CAB011577" Approved Supported Nucleoplasm NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 58: Brain - Synaptic function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "CAB011577: AB_727019, HPA002847: AB_1080107" "unprognostic (7.01e-2)" "unprognostic (4.86e-2)" "unprognostic (1.41e-1)" "unprognostic (1.25e-4)" "unprognostic (1.17e-1)" "unprognostic (1.61e-2)" "unprognostic (1.72e-2)" "unprognostic (1.67e-1)" "unprognostic (2.07e-1)" "unprognostic (9.63e-3)" "unprognostic (2.05e-3)" "unprognostic (1.66e-1)" "prognostic favorable (5.54e-4)" "unprognostic (7.67e-3)" "unprognostic (1.29e-1)" "unprognostic (2.67e-3)" "unprognostic (1.99e-1)" 2.0 1.6 4.9 1.1 6.7 2.5 2.5 0.0 11.7 3.9 0.0 1.9 0.9 2.6 1.9 3.5 1.7 1.8 3.8 6.8 0.0 3.5 1.2 4.6 0.8 0.0 2.5 3.8 2.4 2.4 1.7 3.2 0.0 3.6 1.2 12.2 2.2 2.3 1.7 2.2 0.9 2.5 0.0 1.2 2.4 7.1 5.7 1.7 3.0 2.0 1.1 2.7 3.4 5.4 1.1 10.0 2.6 2.2 2.4 3.6 1.7 1.7 3.0 2.0 2.5 3.3 1.5 1.5 0.3 1.0 4.5 0.5 3.2 1.8 4.3 0.4 1.7 0.1 5.5 2.1 1.1 0.2 0.7 1.7 1.9 5.4 4.9 1.3 1.0 1.6 0.2 1.5 2.7 1.0 0.6 0.8 5.2 0.9 2.3 0.6 3.0 0.1 1.8 7.1 0.5 3.2 2.7 0.9 1.5 4.4 1.3 0.4 6.2 2.5 1.7 5.5 1.3 0.3 0.1 0.3 1.4 0.4 3.0 5.7 0.5 1.1 0.3 0.3 0.1 0.1 0.2 0.1 0.1 0.3 0.3 0.2 2.0 0.2 0.3 0.5 0.1 0.1 4.9 6.7 0.0 11.7 6.8 0.0 0.0 2.5 0.0 0.0 5.7 5.4 9.4 25.6 24.8 37.5 2.8 0.9 10.7 0.7 4.6 19.0 7.9 6.3 12.9 5.7 5.3 7.3 33.3 27.4 3.8 1.3 7.9 7.7 34.3 6.5 8.4 6.3 2.4 2.7 216.6 9.6 3.1 7.4 7.7 7.9 1.3 3.9 6.1 3.4 4.2 80.8 116.1 1.6 2.0 4.4 0.5 55.3 5.9 4.9 0.0 34.7 4.6 23.5 0.0 41.7 79.7 8.2 0.8 5.3 4.3 16.2 0.6 8.9 4.0 20.4 32.9 7.2 8.4 5.8 10.1 4.2 1.3 47.3 2.3 5.7 1.8 22.9 CEACAM16 DFNA4B ENSG00000213892 "CEA cell adhesion molecule 16, tectorial membrane component" Q2WEN9 19 44699151-44710718 "Disease related genes, Human disease related genes, Predicted secreted proteins" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in single" "pancreas: 2.0" "Group enriched" "Detected in some" 7 "Bipolar cells: 7.7;Skeletal myocytes: 20.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "U-266/70: 1.5" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA045075 Uncertain "Secreted in other tissues" NA NA "Cluster 25: Pancreas - Digestion" "Cluster 29: U-266 - Adaptive immune response" "Cluster 50: Fibroblasts - ECM organization" "HPA045075: AB_10959617" "unprognostic (1.27e-1)" "unprognostic (3.73e-1)" "unprognostic (3.12e-1)" "unprognostic (3.32e-2)" "unprognostic (4.72e-1)" "unprognostic (1.42e-2)" "unprognostic (7.76e-2)" "unprognostic (3.59e-2)" "unprognostic (7.81e-3)" "unprognostic (3.88e-2)" "unprognostic (2.05e-1)" "unprognostic (1.06e-1)" "unprognostic (1.86e-1)" "unprognostic (7.94e-2)" 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.2 0.0 0.0 0.0 0.0 1.5 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.7 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 20.6 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.5 0.0 CEP250 "C-NAP1, CEP2" ENSG00000126001 "Centrosomal protein 250" Q9BV73 20 35455164-35519280 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cilium biogenesis/degradation" "Cone-rod dystrophy, Deafness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA064875 Supported Centrosome NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 63: NK-cells & T-cells - Immune response" Centrosome "HPA064875: AB_2685379" "unprognostic (6.35e-2)" "unprognostic (2.94e-1)" "unprognostic (2.31e-1)" "unprognostic (1.21e-3)" "unprognostic (1.99e-1)" "unprognostic (1.94e-1)" "prognostic unfavorable (1.77e-7)" "unprognostic (1.60e-1)" "unprognostic (7.81e-2)" "unprognostic (3.47e-2)" "prognostic favorable (9.27e-6)" "unprognostic (1.42e-1)" "prognostic unfavorable (1.97e-6)" "unprognostic (1.30e-1)" "unprognostic (6.40e-2)" "unprognostic (2.90e-3)" "unprognostic (4.57e-2)" 7.2 8.4 12.8 13.5 12.8 22.6 6.4 12.7 11.9 11.3 11.3 10.6 6.9 10.5 8.9 10.4 11.8 7.5 6.8 11.6 13.4 6.2 6.7 7.1 23.3 11.6 12.5 14.2 7.3 12.7 12.2 6.5 11.1 12.2 8.3 15.7 10.1 8.7 9.4 13.3 11.2 9.7 9.8 20.2 8.3 18.8 14.9 16.3 8.7 6.9 14.3 9.8 10.4 11.6 33.9 38.2 18.5 34.6 27.6 24.8 27.4 16.5 18.4 25.8 20.3 51.2 27.0 36.4 21.5 23.7 80.4 36.6 20.0 50.7 28.7 6.9 8.2 68.1 31.0 49.0 16.7 33.7 36.6 17.7 30.0 43.7 61.9 29.3 27.0 38.3 23.7 33.8 44.2 17.4 41.5 34.0 12.4 18.0 43.1 23.6 53.6 10.1 24.7 38.4 24.9 27.7 45.6 30.3 21.5 14.9 21.3 29.3 43.7 113.5 29.3 42.4 23.8 11.7 13.6 33.9 63.1 22.4 19.9 20.2 2.0 5.2 10.5 2.5 6.5 5.7 4.4 8.5 4.1 6.7 5.3 6.0 0.8 7.4 1.7 14.1 5.1 4.6 12.8 12.8 12.7 11.9 11.6 13.4 11.6 12.5 11.1 9.8 14.9 11.6 3.4 6.4 7.2 7.5 14.6 1.7 6.2 3.6 8.6 21.7 4.5 5.3 13.0 5.7 12.7 9.2 12.5 11.6 15.7 7.0 5.9 5.5 11.7 16.2 8.0 4.8 3.0 19.5 13.6 2.0 6.4 7.6 11.7 9.7 5.1 11.8 7.1 3.8 9.1 16.8 17.6 5.4 2.0 9.0 2.7 20.0 4.4 7.7 1.8 5.6 4.2 8.3 20.6 5.0 5.1 5.1 3.6 3.8 18.7 5.2 5.1 2.2 19.5 28.7 0.0 9.9 6.7 24.1 14.8 10.6 2.7 3.0 15.9 5.5 6.6 3.8 CEP290 "3H11Ag, BBS14, CT87, FLJ13615, JBTS5, KIAA0373, LCA10, MKS4, NPHP6, POC3, rd16, SLSN6" ENSG00000198707 "Centrosomal protein 290" O15078 12 88049016-88142099 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cilium biogenesis/degradation, Protein transport, Transport" Activator "Bardet-Biedl syndrome, Ciliopathy, Disease variant, Joubert syndrome, Leber congenital amaurosis, Meckel syndrome, Mental retardation, Nephronophthisis, Obesity, Senior-Loken syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Rod photoreceptor cells: 150.5;Spermatocytes: 143.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB029995, HPA043918, HPA064397" Approved Supported Centrosome NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 1: K-562 - Erythropoiesis" "Cluster 46: Photoreceptor cells - Phototransduction" Centrosome "CAB029995: , HPA043918: AB_2678730, HPA064397: AB_2685255" "unprognostic (7.42e-2)" "unprognostic (4.02e-1)" "unprognostic (1.50e-1)" "unprognostic (1.19e-1)" "unprognostic (3.26e-1)" "unprognostic (8.90e-2)" "unprognostic (1.45e-4)" "unprognostic (2.06e-1)" "unprognostic (1.10e-1)" "unprognostic (1.33e-1)" "unprognostic (2.94e-2)" "unprognostic (7.25e-2)" "prognostic unfavorable (3.21e-6)" "unprognostic (2.26e-1)" "unprognostic (1.77e-1)" "unprognostic (2.44e-2)" "unprognostic (3.84e-3)" 5.2 5.1 2.7 4.0 3.4 2.8 5.0 3.1 3.8 7.9 1.9 6.3 1.5 6.4 2.7 2.4 8.0 2.6 4.5 2.8 2.9 7.1 3.6 5.0 3.6 2.8 3.0 12.3 4.6 9.0 8.4 3.3 3.0 6.8 2.6 7.2 3.5 2.1 2.9 3.7 4.6 2.9 2.7 4.5 4.8 8.6 2.9 4.3 7.3 1.2 2.6 6.0 4.9 4.3 8.3 4.9 9.8 2.0 4.2 16.1 3.8 8.2 6.6 5.8 5.0 7.3 3.3 7.6 3.6 6.1 9.1 6.4 2.7 5.2 9.1 4.2 4.7 7.5 4.5 4.7 7.6 10.0 3.4 8.3 3.3 12.5 10.4 11.3 11.3 6.5 15.4 1.4 11.0 3.8 5.7 6.2 2.5 1.3 8.5 4.5 11.6 5.1 4.9 6.1 4.7 8.3 5.0 2.5 6.4 7.6 11.3 3.3 10.0 9.5 5.5 8.1 10.7 6.0 10.4 8.2 3.5 3.7 3.9 0.0 0.0 0.1 0.6 0.1 0.8 0.2 0.7 0.5 0.0 0.3 0.7 0.5 0.0 0.5 0.2 0.6 0.5 0.0 2.7 3.4 3.1 3.8 2.8 2.9 2.8 3.0 3.0 2.7 2.9 4.3 29.0 86.6 32.1 56.2 22.5 6.4 16.9 17.5 17.1 65.9 15.1 16.5 50.0 25.8 35.2 29.5 102.2 13.0 28.6 8.4 7.9 26.0 70.6 89.0 57.0 24.6 4.9 12.4 91.8 13.1 8.8 26.1 14.3 32.1 19.0 56.2 13.9 5.7 13.9 65.6 93.7 17.4 34.6 6.3 7.4 29.4 28.6 13.5 14.2 30.9 11.4 35.0 33.0 67.3 100.4 19.0 6.5 37.6 22.5 9.2 6.9 11.0 81.8 150.5 32.9 42.5 32.2 143.9 53.5 6.4 5.5 5.6 23.7 46.1 15.8 9.4 CEP78 "C9orf81, FLJ12643" ENSG00000148019 "Centrosomal protein 78" Q5JTW2 9 78236062-78279690 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cilium biogenesis/degradation" "Ciliopathy, Cone-rod dystrophy, Deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 110.5;dendritic cells: 106.8;NK-cells: 249.3;Spermatocytes: 82.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "NK-cell: 39.1" "Group enriched" "Detected in many" 5 "NK-cells: 39.1;T-cells: 18.3" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA048846 Approved NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 63: NK-cells & T-cells - Immune response" "HPA048846: AB_2680537" "unprognostic (4.62e-1)" "unprognostic (6.33e-3)" "unprognostic (2.87e-2)" "unprognostic (1.36e-2)" "unprognostic (2.16e-1)" "unprognostic (1.36e-2)" "unprognostic (5.13e-4)" "unprognostic (6.75e-2)" "unprognostic (8.48e-3)" "unprognostic (2.10e-1)" "unprognostic (1.38e-2)" "unprognostic (7.03e-2)" "unprognostic (1.25e-2)" "unprognostic (2.27e-3)" "unprognostic (4.93e-1)" "unprognostic (1.18e-3)" "unprognostic (3.34e-1)" 2.2 2.9 4.3 4.6 5.0 12.3 4.3 5.9 4.4 4.1 3.8 3.5 2.8 5.6 3.2 3.5 3.4 2.4 1.6 4.2 4.7 3.6 3.5 3.4 6.2 4.6 4.5 4.3 2.5 4.3 2.7 3.9 4.6 3.1 3.9 9.2 3.3 3.4 1.6 3.5 2.9 4.7 5.1 5.0 3.0 15.1 4.3 11.5 3.7 1.7 7.7 3.2 3.0 6.2 31.7 14.5 33.3 20.5 5.4 9.4 22.3 25.6 10.1 15.1 19.1 2.7 8.4 28.9 12.7 9.2 21.4 36.9 49.6 13.7 22.5 24.3 16.6 15.4 17.1 11.4 4.9 26.0 14.6 5.2 2.9 17.1 11.1 7.5 23.4 29.4 12.2 22.4 19.8 20.3 32.6 12.8 35.2 32.7 14.0 32.2 38.4 8.4 9.0 14.0 30.4 21.1 33.7 10.6 8.4 22.7 12.6 6.9 12.5 13.3 22.6 27.5 24.7 13.1 17.8 18.4 11.8 17.6 23.0 0.7 0.8 0.7 18.3 3.4 8.9 5.0 7.9 16.0 2.3 3.4 3.9 12.8 0.5 39.1 5.5 4.2 13.1 8.3 4.3 5.0 5.9 4.4 4.2 4.7 4.6 4.5 4.6 5.1 4.3 6.2 10.3 25.6 9.2 26.1 13.7 5.1 8.1 6.9 8.0 27.1 7.6 10.5 8.9 4.3 7.2 1.8 110.5 14.0 106.8 3.9 5.9 8.4 14.1 18.7 16.9 9.0 7.7 25.7 28.6 6.7 19.5 10.3 10.2 10.4 5.1 20.6 7.1 9.0 9.6 3.3 20.5 8.0 4.1 6.1 6.1 9.9 14.9 10.0 1.8 9.4 9.7 14.7 249.3 27.2 24.6 4.7 4.1 15.1 43.7 3.7 1.0 5.1 22.1 49.4 0.0 14.8 11.3 82.1 34.2 10.0 4.8 4.0 34.0 12.3 13.2 4.0 CERKL RP26 ENSG00000188452 "Ceramide kinase like" Q49MI3 2 181536672-181680665 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 17.1;retina: 16.6" "Cell type enhanced" "Detected in some" "Cone photoreceptor cells: 18.8;Endometrial ciliated cells: 43.5;Proximal tubular cells: 13.4;Respiratory ciliated cells: 38.7;Rod photoreceptor cells: 22.8" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in many" 5 "cerebellum: 9.7" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 28 "SCLC-21H: 58.0" "Not detected" "Not detected" "Region enhanced" "Detected in many" "cerebellum: 14.5" "HPA035443, HPA035444, HPA043203" Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 49: Ciliated cells - Cilium organization" "Nucleoplasm, Cytosol" "HPA035443: AB_2674625, HPA035444: AB_10672093, HPA043203: " "unprognostic (7.52e-3)" "unprognostic (6.13e-3)" "unprognostic (2.09e-1)" "unprognostic (3.92e-3)" "unprognostic (4.46e-1)" "unprognostic (2.71e-3)" "unprognostic (2.59e-1)" "unprognostic (1.39e-2)" "unprognostic (2.76e-1)" "unprognostic (2.27e-1)" "prognostic favorable (5.25e-4)" "unprognostic (4.54e-2)" "prognostic unfavorable (2.10e-4)" "unprognostic (1.37e-1)" "unprognostic (3.65e-2)" "unprognostic (3.07e-2)" "unprognostic (8.45e-2)" 1.2 0.5 0.3 0.2 0.6 0.0 1.0 9.7 0.4 3.1 6.0 2.3 0.2 0.8 0.3 0.5 7.8 0.7 0.5 0.8 0.6 8.0 1.3 5.1 0.9 1.8 2.0 0.3 0.7 0.6 0.7 0.1 1.8 1.0 0.3 16.6 1.0 0.2 0.4 0.4 6.8 0.2 1.8 17.1 1.2 0.5 0.4 0.4 0.9 0.3 1.9 1.3 1.2 1.8 0.0 0.8 0.0 0.0 0.1 0.3 0.0 0.1 0.3 0.3 0.4 0.0 0.3 0.2 0.0 0.3 2.0 0.0 0.4 0.3 0.4 0.0 0.0 0.6 0.5 0.1 0.3 0.6 0.0 0.5 0.9 0.3 0.7 0.3 0.0 0.1 0.0 0.0 0.2 0.0 0.2 0.8 0.4 0.0 0.4 1.2 0.0 0.0 0.9 0.0 58.0 0.6 0.0 0.0 0.0 0.0 0.0 0.5 0.1 1.1 0.8 0.0 0.0 0.3 0.0 0.0 0.9 0.1 0.2 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.3 0.6 9.7 0.4 0.8 0.6 1.8 2.0 1.8 1.8 0.4 1.8 0.0 3.2 0.5 0.3 0.0 0.0 0.1 1.0 0.0 0.5 0.0 0.0 0.7 1.5 4.9 0.0 18.8 0.0 1.5 0.0 9.8 0.0 4.6 43.5 0.7 0.3 1.8 0.0 6.8 0.0 0.1 0.0 0.0 3.3 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.2 2.0 0.0 0.0 2.8 0.0 0.3 0.0 0.0 0.1 2.5 0.0 0.5 0.2 0.0 0.0 0.0 0.4 0.0 2.7 13.4 38.7 22.8 0.0 0.2 0.5 0.4 0.9 0.0 0.0 0.0 0.6 0.0 1.2 0.0 CERS1 "LAG1, LASS1, UOG1" ENSG00000223802 "Ceramide synthase 1" P27544 19 18868545-18896727 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism" Transferase "Disease variant, Epilepsy, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "brain: 298.6;choroid plexus: 92.2" "Cell type enriched" "Detected in some" 5 "Late spermatids: 126.6" "Group enriched" "Detected in many" 5 "glioma: 13.5;melanoma: 4.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AN3-CA: 32.1;HEK 293: 34.7;NB-4: 39.3;NTERA-2: 25.2" HPA045724 Enhanced Approved "Endoplasmic reticulum" NA NA "Cluster 70: Brain - Nervous system development" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 25: Spermatids - Spermatogenesis" "Endoplasmic reticulum" "HPA045724: AB_10969762" "unprognostic (8.25e-2)" "unprognostic (8.91e-2)" "unprognostic (2.12e-2)" "unprognostic (2.14e-1)" "unprognostic (3.59e-2)" "unprognostic (6.47e-2)" "unprognostic (1.15e-2)" "unprognostic (1.13e-1)" "unprognostic (4.02e-1)" "unprognostic (7.04e-3)" "unprognostic (3.52e-3)" "unprognostic (1.92e-1)" "unprognostic (4.59e-2)" "unprognostic (2.99e-2)" "unprognostic (3.15e-2)" "unprognostic (9.15e-2)" "unprognostic (3.49e-1)" 0.9 3.1 206.4 0.8 244.8 0.2 0.6 256.1 216.6 2.1 92.2 3.5 0.1 0.7 0.5 1.0 0.7 2.5 4.3 218.8 200.4 0.8 0.2 0.5 0.0 298.6 233.8 2.8 0.9 2.9 12.8 0.3 240.9 1.4 0.2 4.8 0.9 0.5 21.3 0.6 1.0 1.5 247.7 0.2 1.2 29.3 251.3 0.3 1.0 12.3 0.1 1.7 1.7 248.3 0.2 3.3 19.1 32.1 1.1 0.4 0.8 2.2 0.1 5.4 3.9 15.7 1.2 0.1 22.0 1.4 4.4 0.3 13.8 0.6 2.1 0.0 34.7 0.2 0.7 11.7 2.4 3.4 0.5 1.2 0.2 1.7 0.6 6.0 1.3 0.2 2.2 0.2 3.7 8.4 0.3 39.3 25.2 0.1 0.7 0.2 0.6 0.7 4.1 0.0 17.8 15.8 0.8 0.1 14.1 6.0 5.5 20.5 0.5 0.1 4.3 3.4 4.8 0.7 0.5 0.1 0.2 1.2 12.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 206.4 244.8 256.1 216.6 218.8 200.4 298.6 233.8 240.9 247.7 251.3 248.3 0.2 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.0 3.6 0.6 1.3 0.6 0.0 0.0 0.0 2.1 0.0 0.1 0.2 0.0 0.0 21.1 0.3 0.4 0.6 0.0 0.0 0.0 0.2 0.0 1.0 0.0 1.1 0.0 1.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.4 126.6 1.2 0.2 1.8 0.0 0.0 10.1 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.1 0.0 0.1 0.0 1.6 0.0 1.0 0.4 1.4 2.9 0.0 0.4 0.3 0.1 0.4 0.0 0.0 CFB "BF, BFD, H2-Bf" ENSG00000243649 "Complement factor B" P00751 6 31945650-31952084 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Complement alternate pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Age-related macular degeneration, Disease variant, Hemolytic uremic syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 18 "liver: 2613.2" "Cell type enhanced" "Detected in many" "Ductal cells: 873.6;Exocrine glandular cells: 197.3;Hepatocytes: 284.0;Pancreatic endocrine cells: 318.0;Proximal enterocytes: 139.7" "Cancer enhanced" "Detected in all" "liver cancer: 78.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC diff: 15.0;ASC TERT1: 23.0;EFO-21: 25.1;fHDF/TERT166: 14.1;HSkMC: 19.1;U-87 MG: 10.1" "Low region specificity" "Detected in all" "HPA000951, HPA001817, HPA001832, CAB016381" Supported Approved "Endoplasmic reticulum,Vesicles,Cell Junctions" "Secreted to blood" NA NA 879000000 120000000000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 62: Liver - Hemostasis" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 1: Pancreatic cells - Digestion" "Endoplasmic reticulum, Vesicles" "Cell Junctions" "CAB016381: AB_627562, HPA000951: AB_2797216, HPA001817: AB_1078779, HPA001832: AB_1078778" "prognostic favorable (2.76e-5)" "unprognostic (1.02e-1)" "unprognostic (1.44e-1)" "unprognostic (7.94e-2)" "unprognostic (1.82e-2)" "unprognostic (8.56e-2)" "unprognostic (8.08e-3)" "unprognostic (8.81e-2)" "unprognostic (3.51e-1)" "unprognostic (2.26e-2)" "unprognostic (1.32e-2)" "unprognostic (6.57e-2)" "prognostic unfavorable (1.53e-5)" "unprognostic (1.36e-1)" "unprognostic (5.13e-2)" "unprognostic (1.05e-2)" "unprognostic (3.68e-2)" 143.7 18.0 3.6 32.8 3.6 0.1 28.5 3.4 9.9 16.3 3.9 22.3 28.1 8.2 14.2 24.1 53.7 0.8 42.6 3.7 3.4 58.7 2613.2 39.2 4.2 4.1 3.7 9.9 51.8 0.2 17.7 5.0 3.8 60.3 14.5 1.4 43.3 0.0 3.0 7.7 73.1 48.3 3.4 12.9 54.5 2.1 3.7 1.9 15.5 0.7 6.7 17.8 9.2 3.6 0.5 1.9 0.1 0.0 15.0 23.0 0.1 0.0 0.2 1.1 0.0 0.1 8.6 0.1 25.1 14.1 0.6 6.0 0.0 1.8 1.2 1.0 0.3 0.7 0.4 0.5 0.0 1.0 0.4 19.1 0.4 0.6 0.5 1.3 0.2 0.1 0.3 0.7 0.1 0.2 0.1 0.3 0.4 0.0 0.4 0.3 0.3 1.3 1.7 0.5 0.0 0.1 0.0 1.3 0.0 0.0 0.0 0.2 0.0 3.4 1.2 0.4 0.4 0.7 2.1 1.0 10.1 0.6 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 3.6 3.6 3.4 9.9 3.7 3.4 4.1 3.7 3.8 3.4 3.7 3.6 1.0 0.0 16.9 0.0 2.6 0.8 0.9 64.8 11.4 0.3 4.9 0.9 0.4 44.3 127.3 5.5 0.0 0.1 0.0 3.7 3.9 873.6 0.0 1.9 0.4 3.9 2.4 16.0 0.2 197.3 0.2 34.6 20.9 1.2 0.0 0.0 11.7 284.0 1.0 0.0 0.2 8.5 18.3 19.7 1.0 0.0 2.8 1.1 0.0 5.6 18.1 0.4 0.0 0.0 0.0 318.0 10.6 0.0 0.1 8.6 139.7 17.1 75.4 0.7 0.0 1.0 12.6 0.1 0.1 3.9 1.8 1.6 1.6 0.0 12.4 4.5 CFH "ARMD4, ARMS1, FHL1, HF, HF1, HF2, HUS" ENSG00000000971 "Complement factor H" P08603 1 196652043-196747504 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Complement alternate pathway, Host-virus interaction, Immunity, Innate immunity" "Age-related macular degeneration, Cancer-related genes, Disease variant, Hemolytic uremic syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 6 "liver: 1676.3" "Group enriched" "Detected in many" 4 "Fibroblasts: 448.0;Hepatocytes: 1114.8;Leydig cells: 283.9" "Cancer enriched" "Detected in all" 9 "liver cancer: 151.1" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "MAIT T-cell: 18.7" "Lineage enriched" "Detected in single" 26 "T-cells: 18.7" "Cell line enhanced" "Detected in many" "HHSteC: 123.1;HSkMC: 119.5;hTERT-RPE1: 374.9;RT4: 227.0" "CAB016385, CAB016769, HPA038922, HPA049176, HPA053326" Supported Approved Vesicles "Secreted to blood" NA NA 396000000000 100000000000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 50: Fibroblasts - ECM organization" Vesicles "CAB016385: AB_627572, CAB016769: , HPA038922: AB_2676271, HPA049176: AB_2680663, HPA053326: AB_2682113" "unprognostic (2.40e-1)" "unprognostic (9.86e-2)" "unprognostic (1.22e-1)" "unprognostic (8.39e-2)" "unprognostic (5.40e-3)" "unprognostic (1.80e-1)" "unprognostic (3.75e-3)" "unprognostic (7.40e-2)" "unprognostic (1.06e-1)" "unprognostic (1.04e-1)" "unprognostic (9.08e-2)" "unprognostic (2.08e-1)" "prognostic unfavorable (1.92e-6)" "unprognostic (6.50e-3)" "unprognostic (4.49e-3)" "unprognostic (1.73e-1)" "unprognostic (1.37e-1)" 125.3 42.1 18.1 32.7 21.5 1.3 66.9 20.0 29.6 76.8 43.0 51.0 30.5 12.8 15.9 63.8 24.2 133.6 301.5 18.1 18.6 25.5 1676.3 70.8 27.4 19.3 19.0 165.1 14.0 6.4 16.0 26.1 19.9 23.0 80.2 4.3 126.7 24.0 21.1 74.5 52.1 32.5 19.5 13.9 46.9 14.3 21.6 12.1 102.5 84.0 25.9 149.9 27.0 21.1 0.0 64.9 0.0 0.0 96.5 54.7 0.1 25.8 63.1 3.5 13.5 0.1 11.9 0.3 9.6 0.1 0.2 2.2 0.0 23.6 2.6 1.3 0.0 20.0 74.7 0.0 123.1 0.9 0.3 119.5 0.3 18.4 7.9 374.9 79.2 0.0 74.4 2.7 89.4 0.1 0.5 0.1 0.4 0.0 0.1 0.2 89.8 21.0 0.0 227.0 0.0 0.1 0.4 0.0 0.1 0.6 0.1 0.0 5.6 73.6 0.9 0.8 0.8 0.8 0.0 0.3 13.1 0.2 5.8 0.0 0.1 0.0 2.0 0.0 18.7 0.0 6.6 4.0 0.2 0.0 0.4 1.5 0.7 0.0 0.0 0.0 0.0 1.1 18.1 21.5 20.0 29.6 18.1 18.6 19.3 19.0 19.9 19.5 21.6 21.1 73.9 9.6 17.6 0.7 4.2 44.2 63.6 140.6 14.2 2.4 1.3 3.4 10.9 35.8 141.1 5.5 0.0 0.0 3.1 0.1 0.0 6.2 2.6 2.3 3.8 49.8 0.0 52.6 0.6 0.8 0.0 448.0 8.6 1.9 3.8 6.9 47.8 1114.8 1.1 0.0 1.0 0.0 14.2 43.8 62.1 7.4 283.9 5.7 44.4 38.4 0.3 0.3 0.0 0.0 0.2 5.3 0.0 138.8 2.6 13.0 0.0 0.5 115.6 1.4 6.6 94.2 59.6 1.4 1.0 10.9 38.2 0.1 13.2 26.3 0.0 61.5 CFHR1 "CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, H36-1, H36-2, HFL1, HFL2" ENSG00000244414 "Complement factor H related 1" Q03591 1 196819731-196832189 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Cancer-related genes, Hemolytic uremic syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 272 "liver: 2081.3" "Cell type enriched" "Detected in some" 7 "Hepatocytes: 320.0" "Cancer enriched" "Detected in single" 798 "liver cancer: 182.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC diff: 1.0;HeLa: 1.2;HL-60: 2.0;U-266/70: 2.4" "Not detected" "Not detected" "HPA038915, HPA038922, HPA040726" Supported Approved Vesicles "Secreted to blood" NA NA 13000000000 "Cluster 62: Liver - Hemostasis" "Cluster 29: U-266 - Adaptive immune response" "Cluster 15: Hepatocytes - Hemostasis" Vesicles "HPA038915: AB_2676269, HPA038922: AB_2676271, HPA040726: AB_2677101" "unprognostic (2.28e-1)" "unprognostic (3.18e-1)" "unprognostic (3.50e-2)" "unprognostic (1.88e-2)" "prognostic favorable (8.71e-6)" "unprognostic (3.02e-1)" "unprognostic (3.70e-1)" "unprognostic (2.50e-1)" "unprognostic (8.48e-2)" "unprognostic (7.21e-4)" "unprognostic (7.01e-4)" "unprognostic (1.13e-1)" "unprognostic (6.41e-2)" 1.5 0.6 0.1 1.8 0.1 0.0 0.5 0.1 0.1 0.1 0.1 0.2 0.0 0.0 0.0 0.1 0.1 0.1 0.3 0.1 0.2 7.6 2081.3 0.1 6.7 0.1 0.8 0.3 0.3 0.0 0.1 0.1 0.4 0.2 0.2 0.2 0.1 0.0 0.2 0.1 0.7 0.2 0.1 6.1 0.2 0.1 0.2 0.0 0.1 0.2 0.0 0.4 0.2 0.1 0.0 0.0 0.1 0.1 1.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.6 1.2 0.0 0.0 2.0 0.3 0.0 0.0 0.0 0.0 0.3 0.0 0.4 0.1 0.9 0.3 0.0 0.6 0.0 0.3 0.0 0.0 0.3 0.8 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.1 0.1 0.0 0.5 0.3 0.1 0.1 0.0 2.4 0.0 0.4 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.8 0.4 0.1 0.2 0.1 0.5 3.2 0.0 0.0 2.2 0.4 0.1 0.0 0.0 1.2 0.0 0.1 1.8 11.5 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 18.7 0.0 0.0 0.0 9.9 0.0 0.0 0.0 6.0 15.0 320.0 5.6 0.0 0.4 0.0 0.0 16.9 0.4 0.2 1.2 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.1 0.2 0.0 41.0 2.1 0.3 1.5 0.0 0.0 0.3 1.4 5.6 0.1 0.1 CFHR3 "CFHL3, DOWN16, FHR-3, FHR3, HLF4" ENSG00000116785 "Complement factor H related 3" Q02985 1 196774813-196795407 "Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Hemolytic uremic syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 582 "liver: 505.7" "Cell type enriched" "Detected in some" 12 "Hepatocytes: 205.5" "Cancer enriched" "Detected in single" 80 "liver cancer: 27.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "NTERA-2: 1.7;SuSa: 1.5;T-47d: 3.6;U-266/70: 6.4" "Secreted to blood" NA NA 582000000 3100000000 "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 29: U-266 - Adaptive immune response" "Cluster 15: Hepatocytes - Hemostasis" "unprognostic (1.73e-1)" "unprognostic (2.11e-1)" "unprognostic (7.16e-2)" "unprognostic (6.77e-2)" "unprognostic (4.46e-1)" "unprognostic (4.20e-3)" "prognostic favorable (2.86e-5)" "unprognostic (1.78e-1)" "unprognostic (2.05e-2)" "unprognostic (1.98e-1)" "unprognostic (1.19e-2)" "unprognostic (6.11e-3)" "unprognostic (2.06e-10)" "unprognostic (2.67e-4)" "unprognostic (3.00e-1)" "unprognostic (3.29e-2)" "unprognostic (1.32e-1)" 0.8 0.2 0.1 0.2 0.2 0.1 0.2 0.0 0.4 0.3 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.3 0.3 0.2 0.1 0.4 505.7 0.2 0.1 0.1 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.2 0.0 0.0 0.1 0.2 0.0 0.0 0.6 0.1 0.1 0.3 0.0 0.3 0.1 0.0 0.4 0.1 0.6 0.0 0.7 0.1 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.2 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.2 0.2 0.6 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.2 0.4 0.0 0.9 0.0 0.0 0.0 0.3 0.0 1.5 3.6 0.0 0.0 0.1 0.2 0.3 0.0 6.4 0.2 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.4 0.2 0.1 0.1 0.0 0.0 0.0 0.3 0.6 0.0 0.0 0.0 0.0 0.9 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.2 5.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.5 1.8 16.0 0.1 0.0 0.1 1.7 0.0 0.0 0.0 0.0 7.1 205.5 0.0 0.0 0.1 0.0 0.0 8.3 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 4.7 0.4 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.7 CFI "C3b-INA, FI, IF, KAF" ENSG00000205403 "Complement factor I" P05156 4 109740694-109801999 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins" "Complement pathway, Host-virus interaction, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Age-related macular degeneration, Disease variant, Hemolytic uremic syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "liver: 1098.8" "Cell type enhanced" "Detected in many" "Cholangiocytes: 108.7;Hepatocytes: 592.5;Muller glia cells: 147.8;Proximal tubular cells: 223.6" "Cancer enhanced" "Detected in all" "liver cancer: 90.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CAPAN-2: 106.1;Hep G2: 179.8;HSkMC: 67.4;RPTEC TERT1: 190.6" "HPA001143, CAB016777, HPA024061" Supported "Secreted to blood" NA NA 12000000000 "Cluster 85: Liver - Metabolism" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "CAB016777: , HPA001143: AB_1078555, HPA024061: AB_1847129" "unprognostic (1.04e-1)" "unprognostic (5.79e-2)" "unprognostic (1.68e-1)" "unprognostic (6.32e-2)" "unprognostic (1.55e-2)" "unprognostic (8.58e-2)" "unprognostic (2.95e-2)" "unprognostic (3.00e-1)" "unprognostic (2.00e-2)" "unprognostic (5.42e-3)" "unprognostic (1.41e-1)" "unprognostic (3.61e-1)" "unprognostic (8.63e-2)" "unprognostic (1.29e-1)" "unprognostic (3.42e-2)" "unprognostic (1.74e-1)" "prognostic unfavorable (6.06e-4)" 45.1 50.2 8.1 12.6 8.2 0.1 17.4 7.7 13.2 36.8 10.4 7.4 38.0 39.2 80.3 9.3 74.0 73.0 25.0 8.3 9.6 224.9 1098.8 50.7 8.9 15.6 10.2 32.1 26.0 3.1 8.4 24.1 10.7 8.3 6.4 53.0 15.0 26.7 3.9 2.7 22.3 24.3 10.5 33.1 14.4 8.8 9.2 2.3 14.5 4.6 7.5 34.1 8.3 10.6 0.0 0.6 0.0 0.3 0.0 0.2 0.1 1.5 1.4 0.1 0.2 0.0 106.1 0.0 32.9 0.0 0.5 0.0 0.0 0.0 0.0 34.8 0.7 0.0 0.4 179.8 6.2 0.3 0.0 67.4 0.0 0.1 0.0 3.6 4.8 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 190.6 0.5 0.0 0.3 1.6 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.4 0.6 0.0 0.0 0.0 0.1 18.8 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.1 8.2 7.7 13.2 8.3 9.6 15.6 10.2 10.7 10.5 9.2 10.6 48.1 12.8 50.9 3.6 4.0 1.0 12.2 15.2 0.6 3.4 2.1 5.6 2.3 108.7 36.2 64.4 2.1 0.1 0.3 1.7 31.3 69.3 0.2 34.1 46.4 57.7 0.0 2.7 0.3 30.9 0.2 34.3 8.2 33.6 3.8 72.1 55.0 592.5 0.7 1.7 0.2 1.9 0.0 16.7 1.5 0.8 16.8 2.0 0.0 4.7 1.6 147.8 0.0 0.0 0.3 30.8 2.4 0.0 0.0 3.8 17.0 223.6 8.4 7.3 0.0 1.3 9.4 1.6 0.5 1.9 1.1 0.3 3.4 18.5 4.1 12.6 CHAT ENSG00000070748 "Choline O-acetyltransferase" P28329 10 49609095-49667942 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Neurotransmitter biosynthesis" "Acyltransferase, Transferase" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 10 "brain: 13.0;placenta: 5.5" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 15 "NB-4: 20.9" "Region enhanced" "Detected in many" "basal ganglia: 20.6" "Group enriched" "Detected in some" 7 "basal ganglia: 6.5;pons: 7.0;spinal cord: 12.0" "CAB002313, HPA048547, CAB079053" Supported Supported NA NA "Cluster 65: Brain - Ion transport" "Cluster 24: NB-4 - Immune response" "Cluster 33: Fibroblasts - ECM organization" "CAB002313: AB_563661, CAB079053: , HPA048547: AB_2680437" "unprognostic (2.34e-2)" "unprognostic (6.10e-2)" "unprognostic (5.28e-2)" "unprognostic (6.96e-2)" "unprognostic (2.80e-2)" "unprognostic (3.98e-1)" "unprognostic (1.09e-1)" 0.0 0.0 0.6 0.2 2.8 0.0 0.0 0.3 13.0 0.0 0.3 0.3 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 3.1 0.0 0.0 0.0 0.0 7.9 5.1 0.0 0.3 0.0 0.0 5.5 9.4 0.0 0.0 0.9 0.0 0.2 0.0 0.0 0.5 0.0 1.3 0.0 0.0 0.3 0.6 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.5 0.0 0.0 0.8 20.9 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.5 0.2 0.0 0.0 0.1 0.0 0.2 0.1 0.0 0.1 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.6 2.8 0.3 13.0 0.1 3.1 7.9 5.1 9.4 1.3 0.6 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CHCHD10 "C22orf16, MIX17A, N27C7-4" ENSG00000250479 "Coiled-coil-helix-coiled-coil-helix domain containing 10" Q8WYQ3 22 23765834-23767972 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Amyotrophic lateral sclerosis, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 1622.6;skeletal muscle: 1220.9" "Cell type enhanced" "Detected in all" "Distal enterocytes: 1264.7;Distal tubular cells: 2498.5;Hepatocytes: 1879.9;Proximal enterocytes: 1501.3;Proximal tubular cells: 1437.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003440 Enhanced Supported Mitochondria NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "HPA003440: AB_1078348" "unprognostic (3.88e-2)" "unprognostic (2.36e-3)" "unprognostic (8.90e-2)" "unprognostic (9.80e-2)" "unprognostic (7.68e-2)" "unprognostic (5.97e-3)" "unprognostic (1.59e-1)" "unprognostic (1.85e-1)" "unprognostic (2.23e-2)" "unprognostic (2.40e-1)" "unprognostic (1.61e-1)" "unprognostic (5.13e-2)" "prognostic favorable (2.15e-7)" "unprognostic (5.19e-3)" "unprognostic (2.06e-1)" "unprognostic (5.68e-3)" "unprognostic (2.62e-3)" 216.5 136.5 181.6 30.3 188.3 12.5 144.5 183.0 248.9 77.3 262.6 261.2 92.6 35.5 32.4 147.3 43.1 10.9 1622.6 176.6 190.5 409.5 789.7 56.9 28.6 182.2 182.2 29.0 118.0 220.0 112.3 11.9 187.6 106.4 76.2 63.1 148.3 50.5 1220.9 71.8 159.0 17.9 169.5 100.3 160.2 27.8 204.8 14.0 224.7 660.7 34.5 110.2 89.1 179.3 33.1 66.4 19.7 85.9 42.1 27.7 41.9 11.9 22.8 23.5 28.4 124.1 35.1 113.5 30.7 41.2 12.9 99.8 109.2 34.1 20.5 35.9 140.6 22.5 48.8 117.1 73.8 63.6 108.2 53.3 91.9 35.6 9.3 4.9 29.0 17.2 47.7 48.0 20.6 121.8 21.8 48.2 16.9 194.9 183.5 90.0 4.0 209.0 112.7 55.3 41.3 23.8 13.9 145.7 149.7 36.6 54.9 47.0 15.3 1.0 1.1 18.3 0.2 28.8 11.1 62.5 20.5 54.9 11.2 0.2 4.1 11.2 3.0 9.1 1.9 11.7 3.2 4.0 1.8 10.6 4.9 3.5 0.0 0.8 8.2 7.3 4.3 1.2 181.6 188.3 183.0 248.9 176.6 190.5 182.2 182.2 187.6 169.5 204.8 179.3 88.7 12.8 10.5 36.2 294.8 48.2 415.4 28.2 144.5 136.2 156.9 238.2 503.8 268.8 20.5 419.3 114.7 42.5 104.7 1264.7 2498.5 88.1 27.0 76.6 229.8 47.4 310.5 74.3 38.5 54.5 255.7 67.8 300.7 94.3 84.0 171.9 78.1 1879.9 647.5 99.3 37.6 860.9 26.4 262.1 127.5 18.0 48.7 243.1 373.5 15.9 107.8 188.5 25.7 17.1 17.4 45.9 890.1 29.3 297.3 192.4 1501.3 1437.4 10.0 287.8 124.9 254.0 200.4 32.3 43.4 459.3 43.9 105.2 123.0 216.0 952.4 470.1 CHCHD2 "C7orf17, MIX17B, MNRR1" ENSG00000106153 "Coiled-coil-helix-coiled-coil-helix domain containing 2" Q9Y6H1 7 56101573-56106476 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Transcription Activator "Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "A-431: 3195.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027407, HPA052510" Approved Supported Mitochondria NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 39: Non-specific - Mitochondria" "Cluster 24: NB-4 - Immune response" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "HPA027407: AB_10959659, HPA052510: AB_2681856" "unprognostic (8.68e-3)" "unprognostic (2.79e-1)" "unprognostic (8.48e-2)" "unprognostic (2.32e-1)" "unprognostic (3.90e-2)" "prognostic unfavorable (1.90e-5)" "prognostic unfavorable (9.41e-5)" "unprognostic (4.38e-2)" "unprognostic (3.61e-1)" "unprognostic (2.30e-2)" "unprognostic (1.37e-1)" "unprognostic (2.79e-2)" "unprognostic (2.60e-2)" "unprognostic (4.01e-2)" "unprognostic (1.79e-1)" "unprognostic (2.09e-1)" "unprognostic (2.40e-2)" 250.6 665.5 321.4 167.4 331.8 426.3 253.9 361.8 358.5 220.7 351.0 257.6 252.0 219.0 252.4 269.6 210.6 132.1 412.4 325.3 352.7 349.4 316.7 213.8 205.0 340.1 341.5 246.3 315.9 322.9 272.3 151.8 343.2 237.2 191.7 226.2 281.2 196.7 791.4 233.3 243.9 150.5 354.6 223.3 287.6 120.7 352.2 267.7 208.2 591.3 200.2 217.8 214.2 367.9 3195.8 553.5 351.8 732.5 275.9 379.3 261.7 456.7 436.2 584.6 561.3 513.0 517.4 932.1 589.1 285.1 741.3 527.6 456.5 507.4 469.6 609.1 831.5 549.2 422.0 738.9 510.5 745.9 844.8 339.1 571.9 438.0 532.4 312.3 444.1 800.3 1182.9 546.7 486.4 449.9 1007.2 2306.5 760.6 867.3 872.6 668.3 343.3 1539.3 532.5 417.0 671.5 834.3 360.6 874.7 597.1 239.4 1002.5 1046.8 354.2 354.2 823.5 1473.9 683.6 497.1 785.4 1698.9 555.3 802.0 448.0 354.1 509.1 400.6 362.1 458.7 377.4 461.2 387.4 387.2 575.8 435.0 344.9 354.9 268.0 400.9 467.1 785.2 550.9 1066.7 321.4 331.8 361.8 358.5 325.3 352.7 340.1 341.5 343.2 354.6 352.2 367.9 465.1 256.4 284.0 44.4 521.9 717.5 956.6 1072.0 387.0 348.7 758.3 929.8 160.8 513.3 612.1 413.8 62.6 955.1 577.6 807.9 1860.7 1034.0 167.2 593.3 396.0 446.5 541.2 666.1 26.7 1325.1 1259.9 514.7 393.0 622.8 394.3 458.8 377.0 727.2 969.6 492.9 35.6 973.0 752.7 483.5 701.2 213.4 614.2 496.2 763.1 28.1 806.5 769.6 593.2 19.6 43.2 1190.3 974.5 505.9 803.3 1321.7 1138.5 1558.4 559.1 353.7 427.3 620.2 583.8 520.4 574.2 680.8 719.3 1228.8 492.5 633.1 929.0 1464.2 CHD2 "DKFZp547I1315, DKFZp686E01200, DKFZp781D1727, FLJ38614" ENSG00000173575 "Chromodomain helicase DNA binding protein 2" O14647 15 92900189-93027996 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Myogenesis, Transcription, Transcription regulation" "Chromatin regulator, DNA-binding, Helicase, Hydrolase" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA060744, HPA060960" Enhanced Enhanced Nucleoplasm NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 2: Karpas-707 - Immune response" "Cluster 44: Endometrium - Transcription" Nucleoplasm "HPA060744: AB_2684353, HPA060960: AB_2684398" "unprognostic (1.65e-2)" "unprognostic (2.43e-1)" "unprognostic (2.14e-2)" "unprognostic (5.98e-2)" "unprognostic (2.12e-2)" "unprognostic (3.10e-2)" "unprognostic (2.67e-2)" "unprognostic (7.85e-2)" "unprognostic (7.51e-3)" "unprognostic (1.14e-1)" "unprognostic (2.84e-1)" "unprognostic (1.79e-2)" "unprognostic (4.64e-2)" "unprognostic (1.16e-1)" "unprognostic (1.58e-1)" "unprognostic (3.15e-1)" "unprognostic (1.70e-2)" 13.9 12.3 22.7 20.7 25.5 73.5 20.4 42.0 32.7 15.7 32.0 15.2 14.8 19.4 29.1 14.6 16.2 15.6 12.0 21.3 24.7 16.9 15.4 21.6 26.4 29.0 23.3 26.1 19.6 18.2 16.6 20.5 24.5 20.4 14.8 30.8 21.2 13.4 17.4 18.8 18.7 13.3 22.1 23.3 17.7 20.8 25.9 27.0 26.3 14.7 25.4 13.7 16.1 27.6 21.3 11.6 30.6 13.6 17.9 45.3 23.0 19.4 20.0 13.0 16.1 14.5 27.4 5.2 16.1 17.3 22.1 31.1 17.6 19.5 18.0 0.1 10.6 25.3 26.1 12.9 24.6 27.1 19.0 28.7 23.0 15.5 31.1 26.8 22.4 36.7 26.8 57.1 19.9 13.1 14.2 14.0 19.5 10.5 12.6 19.9 27.6 28.4 13.3 28.5 16.8 18.1 34.2 12.3 25.9 30.6 14.1 22.6 36.2 10.7 13.9 9.3 12.8 53.4 23.2 21.6 15.9 15.9 9.4 35.9 10.8 27.7 22.1 6.6 21.8 48.7 21.5 20.5 7.4 39.6 30.1 22.1 53.7 20.6 13.4 27.9 24.9 10.9 22.7 25.5 42.0 32.7 21.3 24.7 29.0 23.3 24.5 22.1 25.9 27.6 59.3 70.5 176.3 182.2 137.8 164.3 112.3 102.3 153.7 71.4 62.6 46.5 42.3 37.1 137.3 46.0 91.8 30.7 116.3 59.6 3.9 36.1 56.5 96.9 61.7 58.6 59.3 65.4 161.5 38.3 28.5 64.5 96.4 189.8 99.3 70.7 25.0 34.9 24.8 57.2 146.2 54.9 91.6 55.1 297.4 39.2 34.8 89.5 96.0 119.9 50.7 34.2 48.4 140.8 155.9 64.2 61.6 37.6 133.0 110.0 39.9 11.5 93.9 82.2 32.9 52.7 64.4 15.3 14.7 125.2 180.7 60.5 153.2 42.9 51.5 143.6 CHM "DXS540, REP-1, TCD" ENSG00000188419 "CHM Rab escort protein" P24386 X 85861180-86047561 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Sensory transduction, Vision" "GTPase activation" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Inhibitory neurons: 94.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003231, CAB016171" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 44: Non-specific - Transcription" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 18: U-2197 - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm Cytosol "CAB016171: AB_2229397, HPA003231: AB_1078518" "unprognostic (6.50e-3)" "unprognostic (1.80e-1)" "unprognostic (1.67e-1)" "unprognostic (1.74e-2)" "unprognostic (2.82e-1)" "unprognostic (4.40e-1)" "unprognostic (6.20e-3)" "unprognostic (1.38e-1)" "unprognostic (1.18e-1)" "unprognostic (3.03e-1)" "unprognostic (2.20e-1)" "unprognostic (1.49e-1)" "unprognostic (1.97e-3)" "unprognostic (4.18e-2)" "unprognostic (6.15e-2)" "unprognostic (2.44e-1)" "unprognostic (7.60e-3)" 9.3 11.1 2.7 7.3 3.4 2.4 7.7 2.7 4.4 9.3 3.6 6.1 4.6 8.8 4.6 6.7 11.0 7.2 7.2 3.9 2.5 12.1 7.7 7.0 7.1 2.9 2.2 7.8 5.9 14.2 3.8 9.5 3.0 7.6 6.4 9.3 5.6 7.1 6.4 4.2 4.7 8.7 1.3 8.1 7.3 4.6 2.9 8.5 10.9 10.5 6.3 7.6 3.5 3.2 16.8 10.9 10.9 7.2 17.4 18.4 6.9 19.3 16.2 13.2 14.4 8.8 15.0 5.7 24.3 14.0 46.1 9.4 23.9 10.9 22.5 10.9 11.4 3.4 14.6 8.4 13.8 14.3 23.8 14.1 10.1 21.4 26.9 14.6 22.9 9.4 11.9 19.0 20.7 4.8 8.8 5.2 16.2 11.6 17.5 9.0 19.5 8.8 12.2 9.5 9.6 14.8 23.3 7.1 18.3 14.9 6.0 6.7 16.4 16.7 11.0 59.0 9.7 7.2 27.7 7.9 18.0 11.9 14.9 2.2 1.9 0.9 1.6 2.3 1.5 1.8 1.3 1.7 1.5 2.1 1.7 1.8 1.0 1.6 1.9 1.4 1.7 1.2 2.7 3.4 2.7 4.4 3.9 2.5 2.9 2.2 3.0 1.3 2.9 3.2 34.5 3.2 11.0 33.6 22.3 6.9 17.6 18.9 15.9 35.2 14.2 10.3 11.9 15.7 15.9 16.5 8.4 9.6 26.5 10.2 19.6 16.3 0.7 13.8 29.5 22.2 18.7 12.6 82.5 12.4 9.6 21.6 15.3 18.4 16.5 18.2 14.6 12.5 15.5 23.5 94.7 11.8 10.2 23.0 9.1 2.1 15.5 21.4 5.4 52.5 19.6 27.5 18.6 78.4 76.5 15.7 11.4 12.4 17.3 18.9 7.5 35.2 17.7 20.9 46.0 28.0 27.8 3.7 12.2 12.8 7.4 18.3 22.1 28.7 9.4 15.6 CHMP2B "CHMP2.5, DKFZP564O123, VPS2B" ENSG00000083937 "Charged multivesicular body protein 2B" Q9UQN3 3 87227271-87255556 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Protein transport, Transport" "Amyotrophic lateral sclerosis, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-2197: 445.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035069, HPA052754" Uncertain Approved Cytosol NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 18: U-2197 - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "HPA035069: AB_10602798, HPA052754: AB_2681936" "unprognostic (7.83e-3)" "unprognostic (7.45e-2)" "unprognostic (2.01e-3)" "unprognostic (4.05e-2)" "unprognostic (1.51e-1)" "unprognostic (2.35e-1)" "unprognostic (1.02e-2)" "unprognostic (1.52e-2)" "unprognostic (9.78e-2)" "unprognostic (8.69e-2)" "prognostic unfavorable (2.11e-5)" "unprognostic (5.76e-2)" "prognostic favorable (1.74e-6)" "unprognostic (6.52e-2)" "unprognostic (2.29e-1)" "unprognostic (6.41e-3)" "unprognostic (1.21e-1)" 26.0 24.2 15.7 22.8 20.2 42.7 26.3 22.3 22.2 28.9 16.2 41.6 38.5 29.5 22.5 35.2 22.6 28.8 27.0 15.1 18.2 29.6 34.5 22.9 21.9 25.1 21.0 24.9 29.2 24.3 30.4 25.0 24.1 34.9 37.5 15.3 24.9 27.7 35.3 26.4 40.8 29.6 23.7 22.1 31.1 16.1 20.3 17.2 43.1 28.0 21.6 42.3 29.7 31.2 68.4 71.6 25.4 17.4 45.0 38.4 29.7 52.8 71.2 45.1 57.1 57.0 115.0 25.3 36.7 60.1 38.6 35.0 31.6 37.6 56.0 41.7 34.7 29.5 24.6 25.4 39.2 44.9 42.5 29.3 63.2 42.9 58.3 42.6 35.8 29.6 17.3 36.7 50.2 53.2 41.1 18.3 32.4 91.1 65.5 21.4 31.0 26.1 36.0 71.3 9.7 10.8 54.2 45.6 91.4 28.8 40.6 13.7 30.6 42.9 36.5 445.0 37.7 37.7 56.3 41.6 47.6 24.8 30.9 124.7 50.7 136.7 27.3 65.2 37.3 49.6 34.6 34.8 55.1 53.4 32.0 32.4 96.8 31.4 67.8 31.3 52.4 37.8 15.7 20.2 22.3 22.2 15.1 18.2 25.1 21.0 24.1 23.7 20.3 31.2 56.2 83.3 68.7 11.4 58.7 132.0 254.5 90.0 53.5 19.9 59.8 52.1 68.8 62.9 85.0 49.7 4.2 75.4 45.7 268.7 138.9 170.6 6.8 86.7 45.2 54.4 46.7 36.2 14.1 261.2 187.0 68.9 48.4 86.9 74.1 27.1 48.5 60.8 86.9 37.0 15.1 80.3 73.2 61.9 87.6 7.5 66.2 72.6 40.9 9.4 62.0 213.9 42.2 10.6 36.0 237.4 241.3 96.3 30.0 226.0 101.7 145.8 90.5 16.3 72.3 58.5 57.5 78.7 76.7 62.8 145.6 180.9 52.9 38.1 81.3 330.3 CHMP4B "C20orf178, dJ553F4.4, Shax1, SNF7-2, VPS32B" ENSG00000101421 "Charged multivesicular body protein 4B" Q9H444 20 33811348-33854366 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Host-virus interaction, Protein transport, Transport" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041401, HPA051751" Enhanced NA NA 53000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 59: Non-specific - Translation" "Cluster 39: CACO-2 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA041401: AB_10965028, HPA051751: AB_2681591" "unprognostic (2.56e-2)" "unprognostic (6.12e-2)" "unprognostic (1.07e-1)" "unprognostic (9.04e-3)" "unprognostic (9.85e-2)" "unprognostic (8.52e-2)" "prognostic unfavorable (5.10e-4)" "unprognostic (1.49e-1)" "unprognostic (4.37e-2)" "unprognostic (1.24e-2)" "unprognostic (6.44e-3)" "unprognostic (1.31e-1)" "unprognostic (6.09e-2)" "unprognostic (2.31e-1)" "unprognostic (5.50e-2)" "unprognostic (1.20e-2)" "unprognostic (3.33e-2)" 105.8 112.3 93.3 75.8 95.3 213.7 102.2 93.9 112.3 112.9 82.5 155.1 103.0 107.8 58.6 159.0 84.4 80.6 147.1 98.4 98.9 122.9 67.7 101.5 70.7 97.7 94.5 94.9 82.1 74.8 74.6 74.7 95.6 90.4 98.7 53.3 118.1 82.4 231.3 120.9 119.9 76.3 93.7 83.0 117.3 60.2 97.5 82.8 88.4 132.6 71.2 132.0 106.9 99.4 206.4 131.3 72.3 69.3 118.8 95.2 114.5 120.4 159.1 126.1 117.5 279.1 171.2 98.1 183.3 122.3 192.0 160.8 83.2 182.3 99.2 51.0 89.3 174.1 90.4 189.3 137.5 86.1 88.1 137.2 99.4 116.3 106.6 125.2 141.9 113.1 84.2 139.0 97.8 130.2 189.8 246.5 63.4 226.3 179.8 97.7 147.2 120.7 142.7 234.0 56.4 68.6 225.0 192.2 165.8 85.1 149.0 123.9 129.9 216.8 85.0 108.7 117.9 132.4 101.3 117.0 176.5 91.6 65.8 0.0 1.8 0.8 0.7 1.7 0.9 1.6 1.1 0.8 1.0 1.1 0.8 0.7 2.3 0.5 1.4 4.0 1.4 0.5 93.3 95.3 93.9 112.3 98.4 98.9 97.7 94.5 95.6 93.7 97.5 99.4 66.0 60.9 54.6 17.9 71.5 298.0 224.4 133.8 113.3 22.5 149.1 64.3 95.9 112.9 148.1 110.3 18.8 197.7 77.9 565.8 144.8 360.9 17.8 81.8 76.1 126.0 127.4 81.6 18.7 497.0 151.2 130.1 112.7 130.6 28.5 22.3 71.7 69.8 215.3 18.5 13.8 212.7 154.6 119.3 383.6 18.8 93.8 140.2 220.5 15.0 289.8 73.6 46.4 10.6 17.4 540.2 536.6 120.7 139.0 426.2 482.1 180.0 101.6 20.9 92.1 79.7 120.5 24.5 29.2 291.0 341.3 440.3 62.9 35.7 227.4 413.2 CHN1 "ARHGAP2, CHN, DURS2, n-chimerin, RhoGAP2" ENSG00000128656 "Chimerin 1" P15882 2 174798809-175005381 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" Neurogenesis "GTPase activation" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "brain: 772.6" "Cell type enhanced" "Detected in many" "Astrocytes: 195.2;Excitatory neurons: 596.4;Inhibitory neurons: 111.7;Microglial cells: 97.4;Oligodendrocyte precursor cells: 149.8" "Cancer enhanced" "Detected in all" "glioma: 18.5" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "memory CD4 T-cell: 6.5;memory CD8 T-cell: 2.1;T-reg: 8.0" "Lineage enriched" "Detected in single" 18 "T-cells: 8.0" "Cell line enhanced" "Detected in many" "BJ hTERT+: 186.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036111 Approved Cytosol NA NA "Cluster 35: T-regs - Unknown function" "Cluster 65: Brain - Ion transport" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "HPA036111: AB_10671241" "unprognostic (3.18e-3)" "unprognostic (4.19e-2)" "unprognostic (9.69e-2)" "unprognostic (3.42e-3)" "unprognostic (1.92e-1)" "unprognostic (2.65e-2)" "unprognostic (7.45e-2)" "unprognostic (9.14e-2)" "unprognostic (3.71e-2)" "unprognostic (1.34e-2)" "unprognostic (5.29e-2)" "unprognostic (2.95e-1)" "prognostic unfavorable (5.07e-4)" "unprognostic (7.31e-3)" "unprognostic (4.07e-1)" "unprognostic (2.08e-2)" "unprognostic (9.46e-2)" 11.8 13.3 368.6 7.3 445.9 0.8 10.5 194.0 772.6 9.2 170.6 10.2 3.3 7.9 38.3 6.9 6.5 11.1 15.1 492.6 241.5 4.7 2.1 19.6 21.5 210.2 225.4 5.8 4.2 43.4 36.3 38.6 210.5 17.0 5.1 39.5 3.2 9.6 2.7 3.8 7.5 13.1 192.4 5.5 7.1 21.3 239.1 3.1 10.2 3.7 18.7 8.7 6.7 422.8 0.4 17.4 57.6 16.3 14.7 67.4 0.4 45.6 186.7 65.1 97.0 0.3 5.4 0.5 1.6 71.8 39.9 2.0 68.0 1.9 30.3 1.3 32.9 11.1 20.1 3.8 34.4 6.4 1.7 53.6 1.9 31.6 11.1 16.1 33.6 30.0 0.7 1.9 57.2 11.8 29.3 2.5 71.7 2.6 23.7 8.2 70.3 0.8 0.9 0.6 71.3 76.3 41.3 0.5 7.3 36.0 3.2 2.2 10.1 26.8 3.9 9.8 20.6 6.4 33.7 0.7 6.7 0.4 6.6 0.4 0.1 0.1 0.3 0.1 0.8 0.2 6.5 2.1 0.0 0.1 1.3 0.4 0.4 0.2 0.2 0.3 8.0 1.0 368.6 445.9 194.0 772.6 492.6 241.5 210.2 225.4 210.5 192.4 239.1 422.8 15.4 3.2 1.9 195.2 1.6 4.5 0.3 0.0 0.0 85.1 7.3 1.4 6.2 1.5 2.6 3.7 27.1 1.2 0.5 0.1 0.0 0.3 24.1 5.3 5.6 17.9 2.4 0.0 596.4 0.6 1.1 28.4 2.0 3.6 0.0 5.1 10.4 0.5 2.7 77.4 111.7 0.0 0.0 0.0 4.0 23.2 3.1 0.9 7.2 97.4 0.0 59.1 0.0 149.8 88.1 0.6 0.0 5.3 1.3 0.6 0.0 0.3 1.0 14.1 13.1 23.8 27.3 17.8 23.6 0.1 3.7 2.1 12.5 5.1 0.2 0.3 CHRDL1 "CHL, MGC1, NRLN1" ENSG00000101938 "Chordin like 1" Q9BU40 X 110673856-110795819 "Disease related genes, Human disease related genes, Predicted secreted proteins" "Differentiation, Neurogenesis, Osteogenesis" "Developmental protein" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "seminal vesicle: 224.4" "Group enriched" "Detected in many" 4 "Astrocytes: 50.3;Fibroblasts: 83.8;Leydig cells: 41.0;Muller glia cells: 81.6" "Cancer enhanced" "Detected in many" "prostate cancer: 16.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 9 "ASC diff: 537.8;ASC TERT1: 724.7;hTERT-RPE1: 341.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000226, HPA000250" Approved "Secreted in other tissues" NA NA 610000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 46: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "HPA000226: AB_1078522, HPA000250: AB_1078521" "unprognostic (5.13e-2)" "unprognostic (6.31e-2)" "unprognostic (8.50e-3)" "unprognostic (2.48e-3)" "unprognostic (1.99e-2)" "unprognostic (1.72e-2)" "unprognostic (7.26e-3)" "unprognostic (1.42e-2)" "unprognostic (4.89e-2)" "unprognostic (5.54e-2)" "unprognostic (3.43e-2)" "unprognostic (3.56e-1)" "prognostic unfavorable (2.36e-4)" "unprognostic (4.75e-3)" "unprognostic (7.91e-2)" "unprognostic (5.01e-2)" "prognostic unfavorable (2.23e-4)" 188.3 7.3 7.1 26.2 14.5 0.9 69.8 8.3 14.1 38.8 6.5 74.8 10.8 148.2 20.2 58.0 53.5 47.9 22.0 9.4 6.2 15.1 1.8 76.3 24.4 4.4 4.5 7.1 12.5 84.9 6.4 21.9 4.0 141.6 35.5 55.6 23.3 224.4 6.1 17.5 22.1 101.3 4.3 16.0 17.9 6.5 5.8 10.9 37.8 34.9 11.7 28.3 20.0 6.3 0.0 0.1 3.3 0.0 537.8 724.7 0.3 7.6 3.3 18.8 16.1 0.0 0.0 0.0 0.0 0.7 0.0 0.0 23.0 0.0 17.6 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 58.7 0.1 1.6 0.0 341.2 0.0 2.0 0.0 0.0 0.1 0.0 1.0 0.3 21.3 0.0 0.0 0.0 0.0 0.1 3.0 0.0 1.7 5.2 0.0 0.0 0.4 1.4 0.0 0.0 0.0 5.8 4.2 60.4 7.8 0.1 0.1 0.0 5.9 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 7.1 14.5 8.3 14.1 9.4 6.2 4.4 4.5 4.0 4.3 5.8 6.3 8.4 0.0 2.7 50.3 0.1 4.8 0.0 0.0 0.6 1.5 0.3 0.4 2.3 0.0 1.8 1.8 0.0 0.1 0.1 0.0 0.0 0.3 0.3 0.0 1.0 13.8 0.0 0.0 4.2 0.0 0.1 83.8 2.0 0.2 1.3 0.3 2.2 0.1 0.2 0.0 9.3 0.0 0.0 0.0 8.1 1.4 41.0 1.1 8.8 1.0 0.0 81.6 0.0 13.6 0.2 0.0 0.0 9.1 1.4 0.3 0.0 4.1 1.5 2.9 0.0 2.7 11.2 0.2 8.2 0.3 4.4 0.1 1.0 0.0 0.0 0.1 CHRNA1 CHRNA ENSG00000138435 "Cholinergic receptor nicotinic alpha 1 subunit" P02708 2 174747592-174787935 "Disease related genes, Human disease related genes, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Ion channel, Ligand-gated ion channel, Receptor" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 8 "skeletal muscle: 170.1" "Cell type enriched" "Detected in some" 48 "Skeletal myocytes: 193.5" "Cancer enhanced" "Detected in many" "glioma: 5.8" "Group enriched" "Detected in some" 13 "cerebral cortex: 12.8;hippocampal formation: 5.5" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 19 "LHCN-M2: 445.4;RH-30: 360.2" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA071554 Enhanced Supported "Plasma membrane" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane" "HPA071554: AB_2686416" "unprognostic (1.49e-1)" "unprognostic (1.97e-1)" "unprognostic (1.22e-3)" "unprognostic (2.28e-2)" "unprognostic (2.96e-1)" "unprognostic (8.55e-3)" "unprognostic (5.34e-2)" "unprognostic (5.29e-3)" "unprognostic (9.59e-2)" "unprognostic (9.64e-2)" "unprognostic (9.66e-2)" "unprognostic (6.37e-2)" "unprognostic (4.18e-4)" "unprognostic (2.04e-1)" "unprognostic (1.31e-1)" "unprognostic (1.86e-1)" "unprognostic (7.18e-2)" 0.2 0.0 0.2 0.2 0.4 0.0 0.5 0.1 12.8 0.6 0.2 1.5 0.2 0.0 0.2 0.6 0.0 0.0 0.3 5.5 0.2 0.0 0.2 0.6 0.8 0.5 0.2 0.0 0.0 0.0 3.3 0.2 0.5 2.0 0.9 0.0 3.2 0.0 170.1 0.5 0.0 0.0 0.3 0.0 0.0 0.4 0.3 1.1 0.0 20.4 1.2 0.0 0.0 0.7 0.0 0.0 0.4 0.0 0.0 0.5 0.0 0.1 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 21.5 0.0 0.2 0.0 0.0 1.4 0.0 0.1 0.2 445.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 360.2 0.0 0.0 0.3 2.9 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.8 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.2 0.4 0.1 12.8 5.5 0.2 0.5 0.2 0.5 0.3 0.3 0.7 0.1 0.0 0.0 0.0 2.8 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.3 4.0 0.0 0.0 1.7 0.0 0.0 0.3 0.0 0.0 0.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.5 0.0 0.1 0.5 0.0 0.6 0.4 1.7 0.3 0.4 1.8 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 193.5 0.3 0.1 0.2 0.0 0.0 0.0 1.8 0.0 0.2 0.0 CHRNA2 ENSG00000120903 "Cholinergic receptor nicotinic alpha 2 subunit" Q15822 8 27459756-27479883 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Ion transport, Transport" "Ion channel, Ligand-gated ion channel, Receptor" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 14 "brain: 72.1;prostate: 29.0" "Cell type enhanced" "Detected in some" "Bipolar cells: 6.5;Inhibitory neurons: 14.8;Prostatic glandular cells: 2.4;Theca cells: 3.4" "Cancer enriched" "Detected in single" 421 "prostate cancer: 30.2" "Region enhanced" "Detected in many" "thalamus: 72.1" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Low region specificity" "Detected in some" HPA048348 Supported "Nucleoplasm,Plasma membrane,Cytokinetic bridge" Yes NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane" "Nucleoplasm, Cytokinetic bridge" "HPA048348: " "unprognostic (1.10e-2)" "unprognostic (1.47e-1)" "unprognostic (2.23e-2)" "unprognostic (3.19e-1)" "unprognostic (6.19e-2)" "unprognostic (6.29e-3)" "unprognostic (1.19e-2)" "unprognostic (2.13e-1)" "unprognostic (1.91e-1)" "unprognostic (7.60e-2)" "unprognostic (1.70e-1)" "unprognostic (1.47e-1)" 0.0 0.5 15.8 0.2 5.5 0.9 1.4 38.1 2.9 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.7 8.0 0.0 0.0 0.2 0.1 15.7 21.5 0.0 0.2 0.0 0.3 0.0 3.5 29.0 0.0 3.7 0.0 0.0 0.1 0.2 0.2 0.0 2.3 0.1 0.0 0.0 72.1 2.9 0.0 0.0 0.0 0.0 0.0 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 15.8 5.5 38.1 2.9 0.7 8.0 15.7 21.5 3.5 2.3 72.1 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.5 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.5 0.3 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 CHRNA4 "BFNC, EBN, EBN1" ENSG00000101204 "Cholinergic receptor nicotinic alpha 4 subunit" P43681 20 63343223-63378401 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Ion channel, Ligand-gated ion channel, Receptor" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 28.8;liver: 58.0" "Group enriched" "Detected in some" 4 "Hepatocytes: 42.0;Horizontal cells: 139.7" "Cancer enhanced" "Detected in some" "liver cancer: 1.4" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 5 "U-2 OS: 2.5" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 6 "midbrain: 21.8;pons: 20.5;thalamus: 33.5" CAB034064 Uncertain NA NA "Cluster 15: Liver - Metabolism" "Cluster 9: U-2 OS - Unknown function" "Cluster 62: Horizontal cells - Visual perception" "CAB034064: AB_2080535" "unprognostic (3.40e-1)" "unprognostic (1.71e-1)" "unprognostic (2.87e-2)" "unprognostic (3.98e-1)" "unprognostic (8.03e-2)" "unprognostic (1.75e-1)" "unprognostic (1.22e-1)" "unprognostic (1.74e-1)" "unprognostic (2.10e-3)" "unprognostic (5.72e-4)" "unprognostic (9.02e-3)" "unprognostic (9.79e-4)" "unprognostic (6.77e-2)" "unprognostic (1.08e-1)" "unprognostic (3.81e-2)" 0.0 0.2 6.7 0.0 6.5 0.0 0.0 0.6 6.2 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 6.7 8.7 3.4 58.0 0.0 0.0 5.7 15.7 0.1 0.0 12.7 0.8 0.0 6.2 0.2 0.0 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 2.5 0.0 1.6 28.8 0.0 0.5 0.0 0.0 0.0 0.0 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.7 6.5 0.6 6.2 6.7 8.7 5.7 15.7 6.2 0.5 28.8 4.9 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 22.4 0.0 0.1 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 4.7 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 42.0 0.0 139.7 8.8 0.0 0.0 1.0 0.0 1.1 0.0 0.0 0.0 1.0 0.0 0.9 0.0 7.5 2.1 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 2.7 0.0 1.7 0.1 0.1 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 CHRNB1 CHRNB ENSG00000170175 "Cholinergic receptor nicotinic beta 1 subunit" P11230 17 7445061-7457710 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Ion channel, Ligand-gated ion channel, Receptor" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 158.4;tongue: 57.7" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 39.0;Skeletal myocytes: 47.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "LHCN-M2: 34.6;RH-30: 71.0" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "HPA005822, CAB011200" Approved NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 47: Cytotrophoblasts - Unknown function" "CAB011200: AB_262151, HPA005822: AB_1079484" "unprognostic (2.89e-2)" "unprognostic (3.43e-1)" "unprognostic (1.08e-1)" "unprognostic (2.67e-2)" "unprognostic (4.19e-2)" "unprognostic (1.60e-1)" "unprognostic (1.84e-1)" "unprognostic (1.09e-1)" "unprognostic (3.15e-2)" "unprognostic (3.56e-1)" "unprognostic (4.35e-1)" "unprognostic (1.70e-1)" "unprognostic (9.13e-2)" "unprognostic (6.91e-2)" "unprognostic (2.49e-1)" "unprognostic (1.90e-1)" "unprognostic (1.59e-1)" 7.0 30.6 6.9 2.4 7.8 9.1 6.7 7.3 7.5 7.5 8.8 6.3 2.9 6.6 5.1 7.0 5.4 1.9 11.5 6.9 6.9 10.7 16.5 5.1 3.6 7.5 7.0 5.4 16.5 9.1 6.7 6.7 7.3 5.1 2.5 3.2 10.7 3.0 158.4 8.1 5.5 3.2 7.3 7.9 5.2 3.2 7.1 6.5 13.0 57.7 3.9 5.5 7.2 8.1 1.6 2.2 3.8 4.5 6.0 4.0 8.6 1.1 3.8 5.6 4.6 1.3 2.0 6.2 4.0 2.5 2.0 13.6 1.4 25.1 2.0 7.6 4.8 3.5 2.3 8.1 2.6 2.2 8.6 8.8 6.8 3.4 11.0 9.3 3.8 12.0 4.6 3.4 34.6 1.0 6.7 4.1 2.7 1.5 1.1 4.4 71.0 15.8 15.3 1.2 0.6 11.1 2.4 4.0 4.7 5.9 3.9 3.0 3.6 2.3 6.4 1.7 5.0 8.1 9.6 1.7 2.1 4.9 2.1 9.9 5.4 13.6 7.9 6.3 6.1 6.7 8.7 8.0 7.0 7.0 7.0 9.2 1.7 11.0 10.4 5.2 7.9 6.1 6.9 7.8 7.3 7.5 6.9 6.9 7.5 7.0 7.3 7.3 7.1 8.1 8.8 0.0 4.8 4.6 8.9 6.4 3.8 12.6 6.2 3.9 9.3 11.2 9.8 4.3 7.2 9.2 2.1 39.0 17.7 5.2 23.5 16.1 2.2 5.1 7.1 10.1 2.4 3.4 1.4 13.4 9.4 8.1 3.6 7.1 13.3 5.8 10.4 10.8 12.6 15.2 1.5 4.8 14.2 7.2 8.7 2.1 21.8 7.9 12.4 1.0 17.0 14.0 29.9 1.0 5.6 17.3 4.9 17.0 5.8 4.1 10.2 15.5 9.5 7.1 0.0 47.3 8.1 2.8 2.8 6.1 6.5 30.4 11.2 12.1 5.9 3.8 CHRNB2 ENSG00000160716 "Cholinergic receptor nicotinic beta 2 subunit" P17787 1 154567778-154580013 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Ion channel, Ligand-gated ion channel, Receptor" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 17.4;retina: 8.3" "Cell type enhanced" "Detected in some" "Bipolar cells: 12.7;Cone photoreceptor cells: 14.6;Horizontal cells: 42.1;Inhibitory neurons: 7.8;Late spermatids: 11.8;Rod photoreceptor cells: 7.6" "Cancer enhanced" "Detected in some" "glioma: 1.9" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "SCLC-21H: 25.7;SH-SY5Y: 25.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 58: Brain - Synaptic function" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 62: Horizontal cells - Visual perception" "unprognostic (1.13e-1)" "unprognostic (6.33e-2)" "unprognostic (8.15e-3)" "unprognostic (3.32e-1)" "unprognostic (4.37e-3)" "unprognostic (2.25e-1)" "unprognostic (3.51e-1)" "unprognostic (1.28e-1)" "unprognostic (3.65e-2)" "unprognostic (2.37e-1)" "unprognostic (1.24e-3)" "unprognostic (1.83e-1)" "unprognostic (4.36e-1)" "unprognostic (2.32e-1)" "unprognostic (1.45e-1)" "unprognostic (5.65e-2)" "unprognostic (1.84e-1)" 0.0 1.0 6.5 0.1 7.5 0.0 0.4 2.2 17.4 0.0 0.0 0.2 0.2 0.0 0.0 0.1 0.0 0.0 0.0 8.7 5.3 0.0 0.0 0.0 0.0 3.8 5.5 0.0 0.6 0.1 3.6 0.0 3.8 0.0 0.1 8.3 0.0 0.0 0.0 0.2 0.1 0.1 0.3 0.0 0.3 0.7 11.8 0.0 0.0 0.0 0.0 0.0 0.0 6.5 0.0 0.6 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 4.3 0.2 0.0 0.1 0.0 0.0 0.0 0.0 25.7 25.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.5 7.5 2.2 17.4 8.7 5.3 3.8 5.5 3.8 0.3 11.8 6.5 0.0 0.0 0.0 1.0 0.0 0.1 0.0 0.0 0.0 12.7 0.1 0.3 1.5 0.0 0.0 0.0 14.6 0.0 0.0 0.0 0.0 0.0 3.5 0.0 0.1 0.2 3.6 0.0 5.8 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 42.1 7.8 0.0 0.0 0.0 0.0 11.8 0.0 0.0 0.0 1.0 0.0 1.3 0.0 1.5 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.6 0.0 0.0 0.0 1.5 0.4 0.0 0.3 0.0 0.0 0.1 0.0 0.0 CHRND ACHRD ENSG00000135902 "Cholinergic receptor nicotinic delta subunit" Q07001 2 232525993-232536667 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Ion channel, Ligand-gated ion channel, Receptor" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 9 "skeletal muscle: 57.6" "Group enriched" "Detected in some" 10 "Muller glia cells: 4.0;Skeletal myocytes: 4.4" "Cancer enriched" "Detected in single" 7 "head and neck cancer: 1.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 49 "RH-30: 99.4" "Not detected" "Not detected" "Not detected" "Not detected" "HPA056404, HPA065404" Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 33: Striated muscle - Muscle contraction" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 37: Myocytes - Muscle contraction" "Plasma membrane" "Nucleoplasm, Cytosol" "HPA056404: AB_2732603, HPA065404: AB_2732734" "unprognostic (1.69e-2)" "unprognostic (7.93e-2)" "unprognostic (3.28e-3)" "unprognostic (7.75e-3)" "unprognostic (6.04e-2)" "unprognostic (1.10e-1)" "unprognostic (7.25e-2)" "unprognostic (1.90e-1)" "unprognostic (4.97e-8)" "unprognostic (7.52e-2)" "unprognostic (2.86e-1)" "unprognostic (2.46e-1)" 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.0 6.3 0.7 0.0 57.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.2 0.0 6.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 99.4 0.0 0.0 0.0 0.8 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.2 0.0 0.2 0.1 0.2 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 4.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 CHRNE ACHRE ENSG00000108556 "Cholinergic receptor nicotinic epsilon subunit" Q04844 17 4897771-4934438 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Ion channel, Ligand-gated ion channel, Receptor" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 8 "heart muscle: 55.3;pituitary gland: 27.6" "Cell type enriched" "Detected in many" 5 "Late spermatids: 161.5" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Immune cell enhanced" "Detected in some" "gdT-cell: 2.5" "Low lineage specificity" "Detected in many" "Group enriched" "Detected in some" 9 "HEL: 5.0;HMC-1: 11.5" "Not detected" "Not detected" "Region enriched" "Detected in single" 14 "basal ganglia: 6.3" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 3: HMC-1 - Innate immune response" "Cluster 25: Spermatids - Spermatogenesis" "unprognostic (2.00e-3)" "unprognostic (1.56e-1)" "unprognostic (3.94e-2)" "unprognostic (4.35e-3)" "unprognostic (6.55e-2)" "unprognostic (2.27e-3)" "unprognostic (7.80e-4)" "unprognostic (7.75e-2)" "unprognostic (3.24e-1)" "unprognostic (1.34e-1)" "unprognostic (3.69e-2)" "unprognostic (6.58e-2)" "unprognostic (8.42e-4)" "unprognostic (1.39e-3)" "unprognostic (1.26e-1)" "unprognostic (5.83e-2)" "unprognostic (5.70e-2)" 0.7 0.4 0.1 0.4 0.1 0.7 0.7 0.6 0.4 0.7 0.0 0.3 0.3 0.4 1.3 0.4 0.6 1.0 55.3 0.2 0.1 1.0 3.5 0.8 0.5 0.3 0.0 0.8 1.7 0.2 27.6 0.6 0.1 0.6 0.0 5.1 0.8 0.2 1.8 2.2 0.8 0.2 0.0 1.8 0.5 0.7 0.1 0.1 0.4 2.1 0.2 0.3 0.5 0.2 0.0 0.0 0.4 0.0 0.0 0.1 0.4 0.2 0.0 0.0 0.1 0.0 0.0 0.2 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.2 5.0 0.0 0.8 0.4 0.0 11.5 0.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.9 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.6 0.2 1.3 2.5 0.4 0.0 0.0 0.1 0.8 0.2 0.4 0.1 0.7 1.1 0.8 0.6 0.1 0.0 0.7 0.1 0.1 0.6 0.4 0.2 0.1 0.3 0.0 0.1 0.0 0.1 0.2 4.9 0.0 0.0 0.3 4.2 1.7 1.4 0.8 1.2 5.0 1.6 2.0 6.5 1.5 0.6 1.8 4.2 0.6 10.2 0.0 1.9 0.3 27.8 0.6 1.1 3.3 0.0 0.0 0.5 0.9 7.3 2.3 1.1 0.8 8.2 1.4 2.9 7.4 3.4 3.3 0.4 0.1 2.0 1.3 13.0 161.5 0.9 9.9 0.0 2.8 5.3 1.1 8.2 0.5 0.7 0.7 0.0 0.4 3.5 1.1 0.0 2.9 0.6 10.0 0.0 0.9 1.1 5.6 8.4 0.2 1.1 11.1 3.5 6.2 0.2 0.7 CHST6 MCDC1 ENSG00000183196 "Carbohydrate sulfotransferase 6" Q9GZX3 16 75472052-75495445 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism" Transferase "Corneal dystrophy, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 13.5;cervix: 9.4" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 60.0;Oligodendrocytes: 17.0;Respiratory ciliated cells: 16.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AN3-CA: 9.3;CAPAN-2: 9.9;NTERA-2: 4.8;SK-MEL-30: 4.1;U-2 OS: 5.0;WM-115: 5.4" HPA068029 Approved "Intracellular and membrane" NA NA "Cluster 11: Basophils - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 49: Ciliated cells - Cilium organization" "HPA068029: " "unprognostic (2.28e-2)" "unprognostic (2.25e-2)" "unprognostic (1.07e-1)" "unprognostic (3.93e-3)" "unprognostic (3.30e-2)" "unprognostic (4.02e-2)" "unprognostic (7.15e-2)" "unprognostic (1.73e-2)" "unprognostic (1.25e-1)" "unprognostic (4.48e-2)" "unprognostic (3.16e-2)" "unprognostic (1.07e-1)" "unprognostic (1.10e-7)" "unprognostic (1.23e-1)" "unprognostic (1.14e-1)" "unprognostic (5.78e-2)" "unprognostic (2.80e-4)" 0.1 5.4 8.6 0.2 11.8 0.1 0.0 8.5 7.9 9.4 3.4 0.8 4.5 0.4 0.2 1.3 1.2 0.1 1.9 7.2 10.7 0.3 0.0 0.9 0.1 12.5 13.2 0.0 0.0 0.2 1.2 0.1 11.5 0.4 1.5 0.3 2.7 0.1 0.1 0.1 3.9 0.3 10.9 0.1 0.1 0.8 13.5 0.1 0.1 0.1 0.0 0.2 0.1 11.7 0.1 0.5 0.6 9.3 0.2 0.3 0.1 0.1 0.0 0.0 0.0 0.2 9.9 0.1 1.1 0.0 0.1 0.1 0.9 0.1 0.0 0.0 0.1 0.0 0.2 1.0 0.0 0.0 0.1 0.3 0.0 0.1 0.0 0.6 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 4.8 0.0 0.1 0.0 0.0 0.0 0.8 0.0 0.1 0.0 0.0 0.1 4.1 1.4 0.0 0.3 0.1 0.0 5.0 0.0 0.0 0.1 0.1 2.1 0.2 0.0 5.4 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.2 0.2 0.0 0.1 0.0 0.0 8.6 11.8 8.5 7.9 7.2 10.7 12.5 13.2 11.5 10.9 13.5 11.7 0.2 0.0 2.4 7.5 0.2 0.0 1.7 0.7 0.0 0.7 0.2 0.1 1.0 0.0 4.8 3.7 0.0 2.1 0.1 3.8 0.0 0.1 1.3 60.0 0.8 0.4 0.0 0.0 0.4 0.0 0.2 1.6 0.0 7.5 1.3 0.2 0.0 0.0 0.2 0.0 1.3 4.0 0.0 0.0 0.0 1.3 0.0 0.4 0.0 1.9 0.0 0.6 0.0 6.0 17.0 0.2 8.9 0.0 0.0 1.5 8.9 0.0 16.4 0.4 0.0 1.0 0.7 0.3 0.6 0.0 0.0 0.7 0.4 0.1 2.2 3.9 CIB2 "DFNB48, KIP2, USH1J" ENSG00000136425 "Calcium and integrin binding family member 2" O75838 15 78104606-78131535 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cancer-related genes, Deafness, Disease variant, Non-syndromic deafness, Retinitis pigmentosa, Usher syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 47.7;lymphoid tissue: 47.8" "Group enriched" "Detected in many" 4 "Early spermatids: 73.1;Late spermatids: 269.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 48 "plasmacytoid DC: 18.7" "Lineage enriched" "Detected in single" 48 "dendritic cells: 18.7" "Cell line enhanced" "Detected in many" "AN3-CA: 44.0;GAMG: 39.0;HAP1: 38.6;SCLC-21H: 38.8;SH-SY5Y: 40.1;SuSa: 49.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036697 Approved NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 25: Spermatids - Spermatogenesis" "HPA036697: AB_10672475" "unprognostic (5.77e-2)" "unprognostic (1.83e-2)" "unprognostic (2.81e-2)" "prognostic unfavorable (7.05e-4)" "unprognostic (1.46e-1)" "unprognostic (2.57e-1)" "unprognostic (1.11e-2)" "unprognostic (6.73e-3)" "unprognostic (1.66e-1)" "unprognostic (9.94e-3)" "unprognostic (3.18e-1)" "unprognostic (7.49e-2)" "prognostic favorable (6.16e-4)" "unprognostic (9.78e-2)" "unprognostic (1.01e-1)" "unprognostic (1.68e-1)" "unprognostic (7.64e-3)" 7.0 12.1 16.7 3.1 16.9 1.6 4.8 15.9 22.9 13.1 13.8 9.6 18.7 9.1 3.1 4.0 5.7 2.8 47.7 18.1 17.4 9.1 1.2 3.0 3.5 20.1 18.3 7.3 5.9 13.4 10.4 3.7 20.1 10.4 7.1 5.0 8.1 8.7 11.4 6.8 24.6 6.6 17.5 3.0 3.9 23.3 16.9 47.8 4.0 1.9 6.5 8.6 7.8 16.2 3.5 8.6 24.2 44.0 1.1 1.4 18.1 2.4 0.9 2.0 4.2 0.0 9.6 0.4 4.8 11.3 39.0 1.9 38.6 7.7 0.6 21.7 26.8 2.6 1.6 1.4 4.3 0.0 3.4 2.1 3.2 3.5 2.0 5.0 4.2 13.0 9.1 0.2 3.7 0.7 1.1 0.4 31.1 1.2 0.3 16.9 0.1 1.0 2.8 0.7 38.8 40.1 5.9 3.1 3.5 49.2 0.6 2.6 0.3 0.1 20.3 2.2 0.3 0.4 0.4 6.7 1.0 0.1 5.4 0.0 0.0 0.0 0.3 0.1 0.2 0.0 0.0 0.1 0.1 0.1 0.1 0.2 0.1 0.0 0.0 18.7 0.0 0.2 16.7 16.9 15.9 22.9 18.1 17.4 20.1 18.3 20.1 17.5 16.9 16.2 11.0 0.0 0.0 1.6 3.6 5.5 26.6 2.3 1.8 2.9 3.4 12.6 11.4 1.5 0.5 1.8 6.2 19.4 17.3 14.9 9.8 3.0 73.1 1.6 8.1 3.0 3.0 3.0 1.6 1.1 15.5 9.5 2.0 1.5 0.0 10.7 2.5 0.4 2.8 5.0 3.9 25.1 2.0 0.6 1.4 269.9 3.4 2.3 7.2 1.0 0.1 18.1 1.0 2.5 0.4 1.5 16.2 2.6 1.7 12.3 35.9 10.6 0.2 2.2 6.6 11.5 4.9 10.0 17.5 0.4 3.1 9.3 2.5 18.0 11.1 11.5 CILK1 "ICK, KIAA0936, LCK2, MGC46090, MRK" ENSG00000112144 "Ciliogenesis associated kinase 1" Q9UPZ9 6 53001279-53061824 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cilium biogenesis/degradation" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 11.0;Cytotrophoblasts: 20.6;Extravillous trophoblasts: 33.9;Syncytiotrophoblasts: 58.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000791, HPA001113" Approved Supported "Nucleoli fibrillar center" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 24: Non-specific - Transcription regulation" "Nucleoli fibrillar center" "HPA000791: AB_2732392, HPA001113: AB_1851385" "unprognostic (1.75e-2)" "unprognostic (1.02e-1)" "unprognostic (5.47e-2)" "unprognostic (2.95e-1)" "unprognostic (2.32e-1)" "unprognostic (1.00e-2)" "unprognostic (1.44e-1)" "unprognostic (1.82e-2)" "unprognostic (1.17e-3)" "unprognostic (5.11e-2)" "unprognostic (1.18e-1)" "unprognostic (8.28e-2)" "unprognostic (8.12e-3)" "unprognostic (1.21e-1)" "unprognostic (1.39e-1)" "unprognostic (1.07e-1)" "unprognostic (2.26e-1)" 7.9 17.9 10.2 4.9 11.0 2.7 10.7 8.4 9.7 8.9 5.1 8.7 9.8 8.0 5.5 8.6 7.4 6.9 8.5 6.8 7.8 4.5 7.5 6.3 5.2 9.4 11.6 9.5 5.0 7.3 1.7 12.1 8.8 9.9 10.7 17.4 17.9 7.3 4.0 8.7 10.4 7.4 8.8 5.6 12.9 4.5 14.9 10.1 6.3 5.0 6.2 6.5 5.8 12.8 7.8 2.9 14.6 10.0 8.9 14.0 17.0 6.9 12.4 10.8 12.3 4.1 2.4 5.7 4.0 21.0 3.5 5.0 17.6 7.1 14.2 19.9 7.0 4.2 3.3 22.3 4.5 5.2 5.4 12.5 7.6 4.6 5.3 7.7 10.2 12.1 8.1 22.6 24.9 6.7 5.6 6.4 5.6 27.0 6.3 8.8 6.5 7.5 4.5 5.6 23.6 10.6 6.7 16.3 9.6 14.2 9.5 10.9 8.5 17.2 8.0 6.5 17.1 6.3 4.8 2.2 3.5 5.0 8.5 2.8 1.0 2.2 1.7 0.8 1.5 1.2 1.2 1.4 1.0 1.5 1.4 1.2 0.5 1.1 0.9 1.4 1.7 0.8 10.2 11.0 8.4 9.7 6.8 7.8 9.4 11.6 8.8 8.8 14.9 12.8 6.3 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.0 0.0 0.0 0.0 0.0 20.6 5.7 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 33.9 5.3 0.0 0.0 0.0 0.0 0.0 0.0 6.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.2 0.0 0.0 0.0 0.0 58.1 0.8 0.0 0.0 0.0 CLCN2 "ClC-2, CLC2, EJM6" ENSG00000114859 "Chloride voltage-gated channel 2" P51788 3 184346185-184361650 "Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Chloride channel, Ion channel, Voltage-gated channel" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 16.2" "Cell type enhanced" "Detected in many" "Distal enterocytes: 81.7;Proximal enterocytes: 27.4;Theca cells: 62.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009397, HPA014545, HPA024108" Approved Approved Cytosol NA NA "Cluster 45: Intestine - Brush border" "Cluster 39: CACO-2 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "CAB009397: AB_2079256, HPA014545: AB_1846881, HPA024108: AB_1846883" "unprognostic (1.13e-1)" "unprognostic (4.01e-2)" "unprognostic (6.48e-2)" "unprognostic (5.11e-3)" "unprognostic (1.15e-1)" "unprognostic (2.53e-2)" "prognostic unfavorable (4.67e-8)" "unprognostic (1.72e-2)" "unprognostic (2.26e-1)" "unprognostic (1.23e-1)" "unprognostic (2.10e-1)" "unprognostic (2.50e-3)" "unprognostic (1.19e-1)" "unprognostic (4.40e-2)" "unprognostic (5.88e-2)" "unprognostic (4.60e-2)" "unprognostic (1.35e-1)" 1.4 5.1 2.2 1.8 3.1 1.0 1.6 3.1 3.0 3.0 1.6 16.2 9.2 3.6 3.8 1.7 2.4 7.5 1.2 2.0 2.4 3.0 1.7 1.2 0.7 3.4 3.0 4.0 4.5 3.4 2.8 1.0 2.7 2.3 10.8 0.6 2.8 2.9 0.9 1.6 8.4 1.6 2.9 1.5 2.2 10.6 3.3 1.3 2.7 0.5 0.9 2.1 2.0 4.3 8.9 3.2 2.5 6.9 2.2 1.8 5.8 2.9 1.7 3.1 2.0 16.8 3.0 3.0 8.2 1.6 8.0 15.1 3.6 3.5 0.9 2.8 4.2 2.7 7.0 7.7 1.3 1.2 2.6 3.6 2.7 2.6 3.0 1.5 2.9 3.3 1.0 1.6 1.1 5.9 0.8 1.6 3.7 7.6 4.4 5.4 2.3 10.7 3.8 6.9 4.0 2.4 3.3 11.4 5.2 1.6 9.4 1.2 1.4 1.5 4.5 7.7 7.7 3.6 5.5 2.1 2.7 5.3 7.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 3.1 3.1 3.0 2.0 2.4 3.4 3.0 2.7 2.9 3.3 4.3 2.2 3.2 4.1 16.6 0.4 1.0 0.9 0.8 1.2 2.1 2.5 2.8 1.2 14.3 1.1 0.0 0.0 1.0 1.9 81.7 0.0 3.7 2.3 2.5 4.5 1.9 3.0 0.8 4.1 2.0 0.6 2.6 2.6 4.4 1.3 11.3 2.5 0.6 0.7 1.7 8.1 3.7 0.0 1.0 0.3 2.7 5.3 1.1 0.0 1.9 0.6 1.7 0.0 6.0 15.1 2.2 16.0 4.9 0.8 0.6 27.4 2.3 2.6 2.5 0.0 0.9 2.1 3.3 1.7 1.1 0.4 1.5 1.2 62.5 9.0 0.5 CLDN14 DFNB29 ENSG00000159261 "Claudin 14" O95500 21 36460621-36576569 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 22 "kidney: 13.8;liver: 39.5" "Cell type enhanced" "Detected in some" "Cholangiocytes: 7.2;Distal tubular cells: 19.6;Ductal cells: 11.8;Exocrine glandular cells: 8.2;Hepatocytes: 22.2;Pancreatic endocrine cells: 21.3" "Cancer enriched" "Detected in many" 6 "liver cancer: 7.9" "Region enriched" "Detected in single" 5 "cerebral cortex: 1.1" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 14 "HDLM-2: 224.1" "Low region specificity" "Detected in many" "Not detected" "Not detected" HPA054707 Uncertain Vesicles NA NA "Cluster 85: Liver - Metabolism" "Cluster 44: HDLM-2 - Immune response" "Cluster 2: Hepatocytes - Metabolism" Vesicles "HPA054707: " "unprognostic (1.14e-1)" "unprognostic (2.21e-1)" "unprognostic (3.74e-2)" "unprognostic (9.43e-2)" "unprognostic (8.20e-3)" "unprognostic (5.54e-2)" "prognostic favorable (1.53e-4)" "unprognostic (3.50e-4)" "unprognostic (2.28e-1)" "unprognostic (2.30e-2)" "unprognostic (2.12e-2)" "unprognostic (4.87e-1)" "unprognostic (7.44e-4)" "unprognostic (2.77e-2)" "unprognostic (7.65e-2)" "unprognostic (2.45e-2)" "unprognostic (9.71e-2)" 0.1 0.0 0.2 0.3 0.0 0.0 0.3 0.0 1.1 0.0 0.0 0.1 0.1 0.1 0.4 0.0 0.0 0.3 0.1 0.1 0.0 13.8 39.5 0.1 0.0 0.1 0.0 0.0 1.0 0.1 0.0 0.2 0.1 0.0 0.1 0.3 0.2 0.0 0.4 0.4 0.1 0.0 0.0 0.2 0.2 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.5 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.8 0.0 0.4 0.0 0.0 0.0 0.0 224.1 0.0 0.0 0.0 0.1 0.0 0.0 3.3 0.0 0.0 0.1 0.0 0.7 2.1 0.1 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0 5.7 0.0 0.0 2.5 15.8 0.0 0.0 0.0 0.3 0.0 3.5 0.0 0.0 0.1 7.4 4.2 0.1 0.7 0.4 6.7 15.7 0.0 1.0 0.3 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.1 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 1.5 0.4 1.0 0.6 0.0 0.0 0.8 0.4 0.7 7.2 0.1 1.8 0.0 0.1 0.0 0.7 19.6 11.8 0.6 0.3 0.2 3.6 0.0 0.0 0.6 8.2 1.3 0.1 0.0 3.4 0.0 0.0 0.4 22.2 0.1 0.0 0.4 0.6 0.0 0.6 0.0 0.5 0.0 0.2 3.6 0.0 0.6 0.0 0.0 1.5 1.0 21.3 0.0 0.4 6.9 0.6 0.0 0.7 0.0 0.0 0.0 0.0 2.0 1.2 0.0 0.0 0.3 0.8 1.4 0.0 0.3 2.3 CLIC5 DFNB102 ENSG00000112782 "Chloride intracellular channel 5" Q9NZA1 6 45880827-46080348 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters" "Hearing, Ion transport, Sensory transduction, Transport, Vision" "Chloride channel, Ion channel, Voltage-gated channel" "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 102.7;skeletal muscle: 289.7;tongue: 98.3" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 509.6;Cardiomyocytes: 285.7;Distal enterocytes: 164.2;Late spermatids: 93.8;Proximal enterocytes: 126.0" "Cancer enhanced" "Detected in many" "ovarian cancer: 11.6" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "MAIT T-cell: 5.1" "Lineage enriched" "Detected in single" 17 "T-cells: 5.1" "Cell line enhanced" "Detected in some" "CAPAN-2: 13.5;EFO-21: 9.2;HDLM-2: 4.7;REH: 11.9;U-266/70: 12.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA074371 Supported "Nuclear speckles,Plasma membrane" NA NA 400000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 29: U-266 - Adaptive immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane" "Nuclear speckles" "HPA074371: " "unprognostic (4.95e-2)" "unprognostic (1.59e-2)" "unprognostic (8.84e-2)" "unprognostic (5.05e-2)" "unprognostic (2.44e-1)" "unprognostic (6.73e-2)" "unprognostic (3.37e-1)" "unprognostic (1.26e-1)" "unprognostic (1.79e-1)" "unprognostic (6.46e-2)" "unprognostic (5.50e-2)" "unprognostic (3.65e-1)" "unprognostic (6.77e-3)" "unprognostic (1.22e-1)" "unprognostic (1.99e-1)" "unprognostic (8.26e-2)" "unprognostic (1.01e-1)" 18.9 1.5 3.2 4.3 4.4 0.2 6.5 1.5 2.9 19.0 0.5 28.6 20.9 2.1 0.9 2.9 4.5 3.0 102.7 2.1 5.0 54.7 0.3 70.8 1.7 2.1 3.8 0.5 1.1 1.7 3.0 16.5 2.2 2.6 25.8 16.9 2.7 1.4 289.7 1.2 36.6 2.3 1.8 44.5 1.6 1.4 5.5 1.0 7.3 98.3 1.9 2.0 2.6 1.9 0.9 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.6 13.5 0.0 9.2 0.0 0.0 0.3 0.0 0.1 0.0 4.7 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.8 0.0 0.0 0.0 0.1 0.4 1.6 0.0 11.9 0.3 0.1 0.1 0.4 0.1 0.0 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.4 0.1 0.0 12.8 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 1.5 0.0 5.1 0.1 2.0 1.3 0.0 0.0 0.3 0.2 0.0 0.3 0.0 0.0 1.0 0.5 3.2 4.4 1.5 2.9 2.1 5.0 2.1 3.8 2.2 1.8 5.5 1.9 59.6 509.6 30.0 4.6 1.4 0.1 0.1 0.0 1.2 0.3 0.5 0.4 285.7 5.7 26.9 14.7 0.0 0.2 0.7 164.2 0.0 1.7 52.9 4.6 0.5 29.8 13.1 0.4 8.6 0.2 0.1 7.9 0.5 5.7 1.3 0.0 0.7 0.0 0.0 0.0 5.4 23.5 0.0 0.0 0.0 93.8 0.9 0.7 0.0 34.7 0.6 53.8 0.0 0.5 2.9 2.9 51.1 0.7 3.4 3.2 126.0 2.9 11.4 1.8 0.0 6.1 4.3 1.0 0.1 0.1 0.1 2.2 5.8 0.1 13.5 4.3 CLRN1 "RP61, USH3, USH3A" ENSG00000163646 "Clarin 1" P58418 3 150926163-150972727 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Hearing, Sensory transduction, Vision" "Deafness, Disease variant, Retinitis pigmentosa, Usher syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 7 "adrenal gland: 4.9;retina: 12.8" "Cell type enriched" "Detected in some" 6 "Muller glia cells: 165.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 30 "NTERA-2: 3.3" "Low region specificity" "Detected in some" "Not detected" "Not detected" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 77: Retina - Visual perception" "Cluster 5: NTERA-2 - Transcription" "Cluster 5: Muller glia cells - Visual perception" "unprognostic (1.00e-3)" "unprognostic (1.26e-1)" "unprognostic (5.54e-1)" "unprognostic (9.68e-2)" 0.0 4.9 0.1 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.1 0.0 1.3 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 12.8 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.1 0.1 0.0 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 25.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 165.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CNGA1 "CNCG, CNCG1, CNG1, RCNC1, RCNCa, RP49" ENSG00000198515 "Cyclic nucleotide gated channel subunit alpha 1" P29973 4 47935977-48016681 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Sensory transduction, Transport, Vision" "Ion channel, Ligand-gated ion channel" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 11 "retina: 264.4" "Cell type enriched" "Detected in many" 6 "Rod photoreceptor cells: 1139.7" "Cancer enhanced" "Detected in many" "urothelial cancer: 4.5" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CAPAN-2: 9.2;RT4: 7.2;U-2 OS: 3.0" "Region enhanced" "Detected in single" "basal ganglia: 1.0" "Not detected" "Not detected" HPA076168 Approved "Nucleoplasm,Vesicles,Plasma membrane" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 79: Retina - Phototransduction" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 46: Photoreceptor cells - Phototransduction" "Vesicles, Plasma membrane" Nucleoplasm "HPA076168: AB_2686781" "unprognostic (2.68e-2)" "unprognostic (4.90e-2)" "unprognostic (1.33e-1)" "unprognostic (8.59e-2)" "unprognostic (2.07e-1)" "unprognostic (1.11e-2)" "unprognostic (1.76e-2)" "unprognostic (3.85e-2)" "unprognostic (1.12e-1)" "unprognostic (1.98e-2)" "unprognostic (3.18e-1)" "unprognostic (2.91e-1)" "unprognostic (5.48e-6)" "unprognostic (1.86e-1)" "unprognostic (1.04e-1)" "unprognostic (4.66e-2)" "unprognostic (8.23e-2)" 3.3 0.4 0.5 0.8 1.4 0.3 1.5 1.6 0.9 1.0 0.6 3.6 2.2 0.4 9.3 9.0 4.1 1.1 0.4 0.7 0.8 2.4 23.5 0.3 0.1 0.4 0.3 0.1 0.8 4.1 0.3 1.0 0.4 2.6 2.4 264.4 4.3 1.7 5.0 5.1 6.3 0.3 0.1 3.4 2.8 0.4 0.7 0.3 0.7 1.3 0.5 3.7 1.9 0.6 2.3 0.9 0.0 0.1 0.0 0.0 0.2 0.0 0.1 0.0 0.2 2.0 9.2 0.1 0.5 0.0 2.7 1.4 0.2 0.3 0.1 0.0 0.6 0.0 0.2 0.8 0.0 0.1 0.2 0.0 0.4 0.0 0.0 0.9 0.0 0.8 0.7 0.5 0.2 0.9 0.0 0.1 0.4 1.1 2.2 0.1 0.0 0.1 0.4 7.2 0.3 0.0 0.2 0.5 0.1 0.2 0.9 0.0 0.3 0.2 3.0 0.1 0.1 0.7 0.8 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.1 0.2 0.3 0.0 0.5 0.0 0.0 0.5 1.4 1.6 0.9 0.7 0.8 0.4 0.3 0.4 0.1 0.7 0.6 7.3 0.0 0.0 0.7 0.1 0.1 1.8 0.5 0.6 97.7 8.7 1.8 0.7 5.7 3.4 62.5 91.8 0.0 0.0 10.6 0.0 10.1 0.4 2.5 0.4 8.7 0.0 2.7 1.2 6.6 0.0 0.3 0.0 3.6 0.0 0.0 0.0 38.0 1.7 45.4 1.1 4.0 0.0 0.8 0.0 0.1 0.3 0.5 0.0 7.5 0.0 163.9 0.0 0.0 0.2 2.1 16.4 0.0 0.0 3.7 24.5 0.4 0.8 1139.7 0.0 0.6 17.1 0.6 1.3 10.3 2.7 0.3 0.2 0.1 4.7 35.1 CNGA3 "ACHM2, CCNC1, CCNCa, CNCG3, CNG3" ENSG00000144191 "Cyclic nucleotide gated channel subunit alpha 3" Q16281 2 98346188-98398601 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Sensory transduction, Transport, Vision" "Ion channel, Ligand-gated ion channel" "Disease variant, Leber congenital amaurosis" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 5.7;intestine: 4.2;pituitary gland: 10.1;retina: 5.9" "Cell type enriched" "Detected in some" 14 "Cone photoreceptor cells: 43.8" "Cancer enriched" "Detected in some" 9 "glioma: 7.9" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 7 "U-87 MG: 6.8" "Group enriched" "Detected in some" 6 "basal ganglia: 1.8;hypothalamus: 1.9" "Not detected" "Not detected" "HPA049378, CAB079025" Approved Approved NA NA "Cluster 77: Retina - Visual perception" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 9: Photoreceptor cells - Phototransduction" "CAB079025: , HPA049378: AB_2732551" "unprognostic (2.34e-2)" "unprognostic (1.83e-2)" "unprognostic (4.96e-2)" "unprognostic (4.81e-2)" "unprognostic (1.13e-1)" "unprognostic (2.18e-1)" "unprognostic (4.17e-4)" "unprognostic (4.65e-2)" "unprognostic (1.86e-3)" "unprognostic (2.88e-1)" "unprognostic (3.85e-3)" "unprognostic (8.98e-2)" "unprognostic (5.90e-2)" "unprognostic (3.71e-2)" 0.1 0.0 0.6 0.5 0.5 0.0 0.2 0.2 0.8 0.0 2.9 4.2 1.0 0.0 0.0 1.5 0.4 0.0 0.0 0.7 5.6 0.1 0.0 0.1 0.0 3.4 1.5 0.0 0.3 0.0 10.1 0.0 3.6 0.0 1.1 5.9 0.2 0.2 0.0 0.0 1.3 0.8 5.7 0.0 0.9 0.5 1.3 0.0 0.0 0.0 0.0 0.6 0.1 4.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 1.0 0.0 0.0 0.0 0.0 6.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.5 0.2 0.8 0.7 5.6 3.4 1.5 3.6 5.7 1.3 4.2 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.1 0.0 1.0 0.0 0.0 0.7 0.0 0.0 0.0 43.8 0.0 0.0 0.0 0.0 0.0 1.3 0.4 0.0 0.1 0.0 0.0 3.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.3 0.0 0.0 0.0 0.9 0.3 0.1 0.0 0.0 0.0 0.6 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.5 1.0 0.0 0.0 0.1 0.1 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 CNGB1 "CNCG2, CNCG3L, CNGB1B, GAR1, GARP, RCNC2, RCNCb, RP45" ENSG00000070729 "Cyclic nucleotide gated channel subunit beta 1" Q14028 16 57882340-57971128 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Ion transport, Olfaction, Sensory transduction, Transport, Vision" "Ion channel, Ligand-gated ion channel" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 17 "retina: 600.2" "Group enriched" "Detected in some" 8 "Cone photoreceptor cells: 331.5;Rod photoreceptor cells: 1111.1" "Cancer enriched" "Detected in single" 6 "head and neck cancer: 2.6" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "EFO-21: 1.5;RPMI-8226: 1.8;SCLC-21H: 5.0;SiHa: 2.9;SK-BR-3: 1.4" "Region enhanced" "Detected in some" "hypothalamus: 4.5" "HPA039159, HPA060355" Approved Vesicles,Cytosol No NA "Cluster 77: Retina - Visual perception" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 46: Photoreceptor cells - Phototransduction" Cytosol Vesicles "HPA039159: AB_10795579, HPA060355: " "unprognostic (5.52e-3)" "unprognostic (4.51e-3)" "unprognostic (1.06e-1)" "unprognostic (2.73e-3)" "unprognostic (6.20e-2)" "unprognostic (1.76e-1)" "unprognostic (8.56e-4)" "unprognostic (3.08e-1)" "unprognostic (9.84e-2)" "unprognostic (2.83e-1)" "unprognostic (2.14e-4)" "unprognostic (5.42e-2)" "unprognostic (1.01e-3)" "unprognostic (5.20e-2)" "unprognostic (1.88e-1)" "unprognostic (4.57e-2)" "unprognostic (9.07e-2)" 0.1 2.5 15.5 1.1 13.2 0.2 0.0 0.0 20.4 0.0 0.0 0.6 0.1 0.0 0.2 0.0 0.1 0.3 0.0 24.5 24.8 0.0 0.1 0.1 0.2 2.8 3.2 0.0 0.5 0.0 0.2 0.4 4.4 0.0 0.4 600.2 0.0 0.1 0.0 0.2 0.6 0.1 2.4 0.1 0.0 0.4 36.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.6 0.0 0.0 0.0 0.0 1.1 0.1 0.0 0.0 0.0 0.0 0.1 0.1 1.5 0.0 0.5 0.0 0.0 1.3 0.0 0.1 0.0 0.3 0.9 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.1 0.1 0.0 0.1 0.0 0.0 1.8 0.0 0.6 5.0 0.0 2.9 1.4 0.0 0.0 0.0 0.0 0.4 0.1 0.2 0.2 0.0 0.1 0.3 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 15.5 13.2 0.0 20.4 24.5 24.8 2.8 3.2 4.4 2.4 36.3 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.5 0.4 0.0 61.6 0.3 0.0 1.1 0.0 0.1 0.0 331.5 6.9 0.0 0.0 0.0 0.4 1.6 0.9 0.1 4.2 0.0 0.0 3.2 0.4 0.9 0.2 0.0 1.3 0.0 0.0 0.0 0.0 0.4 25.2 0.4 0.0 0.0 0.0 0.0 0.7 0.0 0.1 0.0 0.0 0.0 89.5 0.0 1.0 0.1 0.2 1.1 0.0 0.0 0.2 0.0 0.3 0.0 1111.1 0.0 0.1 0.2 0.5 0.7 0.0 0.0 1.4 0.1 0.1 0.0 0.2 CNGB3 "ACHM1, ACHM3, RMCH" ENSG00000170289 "Cyclic nucleotide gated channel subunit beta 3" Q9NQW8 8 86553977-86743675 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels" "Ion transport, Sensory transduction, Transport, Vision" "Ion channel, Ligand-gated ion channel" "Disease variant, Stargardt disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 4.1;retina: 13.1" "Cell type enriched" "Detected in some" 13 "Cone photoreceptor cells: 158.4" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 14 "SCLC-21H: 18.9" "Not detected" "Not detected" "Not detected" "Not detected" HPA057244 Enhanced NA NA "Cluster 77: Retina - Visual perception" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 9: Photoreceptor cells - Phototransduction" "HPA057244: AB_2683380" "unprognostic (5.35e-1)" "unprognostic (1.68e-3)" "unprognostic (1.22e-1)" "unprognostic (2.42e-1)" "unprognostic (3.62e-2)" "unprognostic (2.58e-1)" "unprognostic (6.25e-2)" "unprognostic (1.18e-1)" "unprognostic (2.91e-1)" "unprognostic (2.17e-1)" "unprognostic (3.82e-1)" "unprognostic (9.28e-2)" "unprognostic (2.77e-4)" "unprognostic (1.40e-4)" "unprognostic (1.66e-2)" "unprognostic (8.76e-2)" "unprognostic (1.84e-1)" 0.0 0.0 0.2 0.3 0.3 4.1 0.0 1.2 0.5 0.2 1.7 0.1 0.5 0.2 0.1 0.0 0.9 0.0 0.2 0.3 0.2 0.1 0.0 0.0 0.2 0.1 0.4 0.4 0.6 0.0 0.0 0.1 0.2 0.1 0.0 13.1 0.3 0.0 0.1 1.2 0.1 0.0 0.1 0.1 0.3 2.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.4 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.3 0.1 0.1 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.2 0.0 1.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.0 1.3 0.1 0.0 0.0 0.5 0.3 0.0 0.0 0.3 0.0 1.0 18.9 0.0 0.0 0.7 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.2 0.2 0.1 0.0 0.1 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 1.2 0.5 0.3 0.2 0.1 0.4 0.2 0.1 0.1 0.3 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 1.0 0.0 0.0 0.0 158.4 0.1 1.3 0.0 0.0 0.0 5.6 0.1 0.6 0.2 0.0 0.0 2.4 0.0 0.0 1.3 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 1.5 0.0 0.0 0.0 0.0 11.4 0.0 0.1 0.0 1.0 0.2 1.5 0.0 1.5 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.1 0.1 1.6 0.2 0.0 0.3 0.0 0.1 0.1 0.0 0.0 CNNM2 ACDP2 ENSG00000148842 "Cyclin and CBS domain divalent metal cation transport mediator 2" Q9H8M5 10 102918294-103090222 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Disease variant, Epilepsy, Mental retardation, Primary hypomagnesemia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "choroid plexus: 37.9;parathyroid gland: 31.6" "Cell type enhanced" "Detected in many" "Astrocytes: 60.1;Excitatory neurons: 112.6;Inhibitory neurons: 146.9;Oligodendrocyte precursor cells: 92.5;Oligodendrocytes: 92.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 4 "NK-cell: 1.5" "Lineage enriched" "Detected in single" 4 "NK-cells: 1.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA059954, HPA071631" Enhanced Vesicles NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 16: U-266 - Nucleosome" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles "HPA059954: AB_2684177, HPA071631: AB_2686427" "unprognostic (2.18e-1)" "unprognostic (6.46e-2)" "unprognostic (1.24e-1)" "unprognostic (2.65e-3)" "unprognostic (3.19e-1)" "unprognostic (2.44e-1)" "unprognostic (1.93e-1)" "unprognostic (4.80e-2)" "unprognostic (4.51e-3)" "unprognostic (3.75e-2)" "unprognostic (1.29e-2)" "unprognostic (2.39e-1)" "prognostic favorable (2.39e-8)" "unprognostic (2.44e-1)" "unprognostic (1.13e-1)" "unprognostic (2.65e-3)" "unprognostic (1.56e-1)" 3.3 11.5 5.1 2.3 5.5 9.3 2.5 7.9 5.7 3.7 37.9 7.0 3.8 3.6 2.1 1.7 4.8 4.1 2.1 4.2 3.3 9.1 4.8 3.8 1.5 4.9 4.8 4.8 3.6 31.6 5.7 8.7 4.7 2.7 6.4 5.0 3.0 3.0 1.6 4.5 4.5 3.7 1.8 2.1 3.3 4.5 4.6 1.8 5.6 1.5 1.1 3.2 2.9 9.7 5.0 8.1 3.1 8.5 7.8 3.2 8.6 2.3 9.7 3.1 3.9 5.8 4.3 1.9 3.5 3.4 6.0 6.3 6.9 4.6 2.4 3.3 12.1 2.8 4.2 11.8 4.6 2.0 3.6 4.2 6.6 3.2 10.7 7.9 1.9 5.5 4.8 10.9 1.8 8.6 2.3 2.2 5.1 4.9 5.0 5.5 4.0 2.4 2.4 2.9 4.5 5.8 5.9 1.3 6.3 9.1 10.4 3.7 1.6 4.2 6.2 3.0 4.2 11.7 14.1 3.6 7.4 6.6 1.7 0.3 0.1 0.1 0.2 0.2 0.2 0.3 0.1 0.1 0.1 0.1 0.2 0.1 0.2 1.5 0.0 0.3 0.3 0.1 5.1 5.5 7.9 5.7 4.2 3.3 4.9 4.8 4.7 1.8 4.6 9.7 3.0 6.4 8.4 60.1 7.9 2.4 2.3 1.7 6.8 16.4 3.3 2.4 4.5 2.8 5.6 5.5 12.5 18.8 8.1 46.7 1.9 2.2 10.7 7.4 4.2 4.2 6.7 6.7 112.6 5.4 3.4 6.3 12.8 6.4 3.8 13.7 3.3 6.1 3.8 32.0 146.9 5.0 0.0 3.2 2.5 15.1 3.4 4.7 7.2 39.4 2.3 7.0 2.1 92.5 92.3 2.3 9.0 3.4 6.2 2.0 11.7 5.5 9.5 15.8 13.1 5.7 16.7 15.5 6.9 8.1 4.1 39.8 5.1 3.8 11.6 2.2 CNNM4 "ACDP4, KIAA1592" ENSG00000158158 "Cyclin and CBS domain divalent metal cation transport mediator 4" Q6P4Q7 2 96760902-96811874 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Biomineralization, Ion transport, Sensory transduction, Transport, Vision" "Amelogenesis imperfecta, Cone-rod dystrophy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "retina: 38.8" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 112.6;Distal enterocytes: 103.4;Rod photoreceptor cells: 51.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in all" "SK-BR-3: 45.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017732 Enhanced Uncertain "Plasma membrane,Actin filaments" NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "Actin filaments" "Plasma membrane" "HPA017732: AB_1847395" "unprognostic (1.98e-3)" "unprognostic (8.95e-3)" "unprognostic (1.11e-1)" "prognostic unfavorable (9.14e-4)" "unprognostic (3.42e-2)" "unprognostic (5.28e-2)" "unprognostic (1.54e-3)" "unprognostic (3.36e-2)" "unprognostic (2.17e-1)" "prognostic unfavorable (8.75e-4)" "unprognostic (4.75e-3)" "unprognostic (3.72e-1)" "unprognostic (8.14e-2)" "unprognostic (3.13e-1)" "unprognostic (3.44e-2)" "unprognostic (1.15e-2)" "unprognostic (1.06e-1)" 2.8 3.6 5.0 6.1 6.8 4.9 7.0 11.2 5.4 5.8 2.8 32.4 6.2 4.0 4.7 7.1 10.4 4.4 12.5 4.9 4.4 6.8 4.4 8.0 4.6 4.1 4.5 5.1 7.4 6.3 9.1 5.8 4.2 5.7 34.3 38.8 6.8 5.1 24.8 7.2 11.3 4.7 3.5 5.3 12.8 7.9 4.5 3.5 9.5 13.1 4.9 5.5 6.4 5.7 11.1 7.2 5.7 10.5 5.8 3.9 15.6 4.8 6.8 6.9 9.3 13.2 11.8 8.1 13.5 5.0 9.5 14.1 14.9 8.1 6.3 16.3 11.7 6.4 4.8 7.2 8.1 3.1 6.2 3.8 10.0 11.0 6.6 4.6 3.8 8.0 3.3 22.3 3.6 15.7 6.6 4.5 7.5 20.5 9.8 9.7 2.6 9.3 6.9 8.6 26.7 8.0 9.1 45.7 6.8 15.9 22.3 5.3 3.4 4.0 8.9 8.8 5.4 7.7 6.6 4.0 5.9 6.1 7.2 1.2 0.4 0.1 0.8 0.4 0.2 0.9 0.4 0.4 0.6 0.5 0.2 0.5 0.2 0.2 0.7 0.4 0.2 0.3 5.0 6.8 11.2 5.4 4.9 4.4 4.1 4.5 4.2 3.5 4.5 5.7 4.5 38.5 7.7 12.4 6.4 5.7 4.9 4.0 4.6 43.1 14.7 11.2 14.1 4.3 11.6 7.3 112.6 5.4 6.1 103.4 0.0 3.2 4.9 14.3 4.4 4.0 10.1 0.8 9.8 4.2 1.7 3.2 12.2 16.1 1.3 5.9 2.2 3.3 3.3 33.7 8.3 26.4 6.1 5.4 4.8 1.6 0.9 5.9 0.0 8.4 2.3 8.3 2.1 11.1 14.6 5.2 21.3 1.2 4.5 4.1 22.3 1.2 10.6 51.5 0.0 4.6 4.3 4.6 2.5 7.3 4.1 6.7 5.4 6.7 26.5 6.1 CNPY3 "CAG4A, TNRC5" ENSG00000137161 "Canopy FGF signaling regulator 3" Q9BT09 6 42929192-42939294 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Immunity, Innate immunity" Chaperone "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hofbauer cells: 248.5;Kupffer cells: 233.3;monocytes: 207.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016560 Uncertain "Intracellular and membrane" NA NA 4100000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 57: B-cells - Immune response" "HPA016560: AB_1858173" "unprognostic (5.26e-3)" "unprognostic (6.63e-2)" "prognostic unfavorable (3.03e-5)" "unprognostic (8.15e-2)" "unprognostic (3.12e-1)" "unprognostic (1.79e-1)" "unprognostic (5.70e-3)" "unprognostic (5.11e-2)" "unprognostic (4.77e-2)" "unprognostic (1.94e-2)" "unprognostic (2.26e-3)" "unprognostic (4.54e-2)" "prognostic unfavorable (9.85e-6)" "unprognostic (2.34e-1)" "unprognostic (1.93e-2)" "unprognostic (2.21e-2)" "unprognostic (2.98e-3)" 35.3 31.4 58.2 64.3 59.1 144.6 32.7 59.0 72.8 40.0 70.0 30.9 30.9 37.5 32.3 23.4 49.8 37.8 28.8 59.7 64.2 31.8 64.7 45.4 78.6 70.0 63.1 48.5 90.0 29.0 41.7 47.6 67.0 45.1 29.7 23.9 32.5 33.8 10.9 22.2 50.1 42.0 62.8 105.2 36.7 46.7 65.8 115.8 34.1 16.7 69.2 43.3 30.0 75.8 78.2 75.6 72.8 157.0 118.4 44.8 73.5 60.3 78.9 79.1 91.0 85.2 57.0 82.1 91.0 102.9 170.8 63.7 54.7 68.7 48.2 82.7 61.6 88.6 65.2 134.0 70.0 155.7 173.3 54.3 41.7 61.2 67.4 113.9 72.4 77.6 73.3 157.3 51.9 147.9 141.4 188.8 59.1 367.3 42.1 97.2 50.6 123.2 79.6 58.6 78.5 68.9 37.7 38.6 134.4 93.4 49.8 334.6 54.6 82.7 82.9 30.9 66.0 107.0 78.9 115.0 34.2 178.6 70.9 212.7 483.3 249.0 115.2 336.3 110.9 267.3 101.1 126.1 407.0 258.7 112.6 115.1 852.8 132.3 327.2 696.4 102.2 404.5 58.2 59.1 59.0 72.8 59.7 64.2 70.0 63.1 67.0 62.8 65.8 75.8 32.3 12.8 11.1 4.2 132.1 22.8 32.1 41.1 31.9 41.6 25.6 29.7 16.9 22.8 26.2 23.9 14.6 51.1 176.5 16.7 7.9 47.4 61.0 25.9 24.2 36.7 55.3 47.9 5.1 34.1 180.8 33.9 20.9 31.8 46.3 81.5 42.1 58.9 248.5 1.7 6.7 31.1 34.6 233.3 61.7 81.7 33.5 184.3 30.2 18.7 207.0 20.8 62.8 4.5 6.6 27.9 34.9 30.1 70.7 50.8 38.4 18.1 32.8 11.1 19.7 12.6 28.0 72.3 39.9 23.9 17.0 36.1 64.1 39.8 36.5 37.9 CNTN2 "AXT, TAG-1, TAX, TAX1" ENSG00000184144 "Contactin 2" Q02246 1 205042937-205078289 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins, Transporters" "Cell adhesion" Epilepsy "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 8 "brain: 248.9" "Cell type enriched" "Detected in some" 11 "Oligodendrocytes: 335.5" "Cancer enriched" "Detected in some" 9 "glioma: 6.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "NTERA-2: 3.9;SCLC-21H: 9.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001397, HPA012497" Approved "Secreted in brain" NA NA 58000 "Cluster 70: Brain - Nervous system development" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA001397: AB_1847146, HPA012497: AB_1847147" "unprognostic (1.90e-1)" "unprognostic (1.86e-1)" "unprognostic (2.87e-2)" "unprognostic (4.52e-3)" "unprognostic (2.98e-2)" "unprognostic (5.96e-2)" "unprognostic (3.25e-1)" "unprognostic (1.43e-2)" "unprognostic (8.56e-2)" "unprognostic (2.40e-1)" "unprognostic (3.44e-3)" "unprognostic (5.62e-2)" "unprognostic (1.73e-7)" "unprognostic (9.82e-3)" "unprognostic (1.19e-1)" "unprognostic (3.35e-2)" "unprognostic (3.07e-2)" 0.3 0.5 82.6 0.4 145.4 0.0 0.1 125.7 112.4 0.6 32.4 2.1 0.1 0.0 0.0 0.2 0.1 0.1 0.7 85.2 96.6 0.1 0.0 0.0 0.0 161.6 128.1 0.0 0.1 0.0 8.0 0.0 139.8 0.3 0.5 1.2 0.4 0.6 0.0 0.5 0.9 0.2 110.1 0.1 0.5 6.1 125.7 0.1 0.1 0.0 0.3 0.2 0.7 248.9 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.5 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 82.6 145.4 125.7 112.4 85.2 96.6 161.6 128.1 139.8 110.1 125.7 248.9 0.4 0.0 0.6 1.3 0.1 0.0 0.0 0.0 0.0 2.4 0.9 1.3 3.7 0.0 0.6 1.8 0.0 0.0 1.2 0.0 0.0 0.6 13.7 0.6 0.5 0.5 0.0 0.0 18.4 0.6 0.0 0.4 0.0 1.2 0.0 2.6 0.0 0.0 0.0 3.3 16.0 0.0 0.0 0.0 0.0 29.0 0.6 0.5 0.0 4.7 0.0 0.2 0.0 9.5 335.5 0.6 0.0 0.0 0.4 0.0 0.0 0.3 1.5 0.8 0.0 0.0 0.3 3.2 0.6 0.0 0.0 0.0 0.5 0.2 0.0 0.2 CNTNAP1 "Caspr, CNTNAP, NRXN4, p190" ENSG00000108797 "Contactin associated protein 1" P78357 17 42682531-42699993 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Cell adhesion" "Disease variant, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 46.7" "Cell type enhanced" "Detected in many" "Astrocytes: 11.4;Bipolar cells: 15.6;Endometrial stromal cells: 15.5;Excitatory neurons: 45.6;Inhibitory neurons: 37.7" "Cancer enhanced" "Detected in all" "glioma: 10.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ hTERT+: 43.5;TIME: 68.5;U-138 MG: 76.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011772 Approved Approved Nucleoplasm NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "HPA011772: AB_1079541" "unprognostic (4.04e-2)" "unprognostic (3.69e-1)" "unprognostic (2.37e-3)" "unprognostic (1.89e-1)" "unprognostic (5.02e-3)" "unprognostic (1.13e-1)" "unprognostic (3.19e-3)" "unprognostic (1.19e-1)" "unprognostic (2.59e-1)" "unprognostic (9.76e-3)" "unprognostic (1.99e-2)" "unprognostic (1.67e-1)" "prognostic unfavorable (4.16e-14)" "unprognostic (9.52e-3)" "unprognostic (2.27e-2)" "unprognostic (3.11e-2)" "unprognostic (7.37e-3)" 7.1 3.6 27.5 5.6 30.8 0.6 5.0 13.5 46.7 12.0 0.0 23.8 1.8 21.8 6.1 2.2 14.0 6.3 8.2 29.5 15.7 6.4 1.5 6.9 2.4 21.6 15.4 15.7 11.5 0.6 19.3 4.5 19.1 7.2 3.9 11.3 2.9 6.5 3.7 2.2 6.0 25.9 8.1 4.9 9.8 3.3 18.8 1.2 4.9 2.5 2.4 8.0 8.5 29.4 4.1 5.4 13.2 4.2 20.0 40.4 0.8 25.6 43.5 18.2 16.5 0.5 1.0 0.1 1.3 27.7 18.6 4.8 6.4 2.0 14.2 9.0 2.1 0.0 24.0 6.4 9.8 0.2 0.4 39.7 0.1 17.5 3.5 29.1 23.3 0.2 1.2 7.6 7.1 0.7 0.1 3.8 4.7 0.3 5.5 0.7 1.4 2.0 4.8 0.0 2.4 7.7 7.6 0.1 4.7 12.0 4.1 2.3 68.5 76.2 12.5 18.0 7.0 8.5 5.7 0.2 21.4 1.7 11.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 27.5 30.8 13.5 46.7 29.5 15.7 21.6 15.4 19.1 8.1 18.8 29.4 1.0 0.0 4.1 11.4 0.5 0.5 0.2 0.4 1.2 15.6 0.2 0.1 1.3 0.0 0.7 0.0 4.2 0.0 0.1 0.1 0.0 0.0 0.9 3.2 15.5 1.2 0.0 0.0 45.6 0.0 0.0 4.2 0.5 1.0 0.0 0.1 1.8 0.0 0.1 1.7 37.7 0.1 0.0 0.0 0.8 0.3 1.5 0.2 0.0 6.5 0.8 0.9 0.0 7.5 5.2 0.1 0.1 0.7 0.4 0.3 0.0 0.1 1.6 3.0 6.6 1.1 6.3 1.4 1.1 0.3 0.3 0.3 0.6 0.2 0.1 0.2 COA7 "C1orf163, FLJ12439, RESA1, SELRC1" ENSG00000162377 "Cytochrome c oxidase assembly factor 7 (putative)" Q96BR5 1 52684449-52698347 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028154, HPA029926" Approved Approved Nucleoplasm,Mitochondria NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Mitochondria" "HPA028154: AB_10600656, HPA029926: AB_10602173" "unprognostic (1.88e-1)" "unprognostic (1.02e-1)" "unprognostic (1.29e-2)" "prognostic unfavorable (8.55e-4)" "unprognostic (2.30e-2)" "unprognostic (5.12e-2)" "prognostic unfavorable (7.01e-5)" "unprognostic (1.14e-1)" "unprognostic (2.27e-2)" "unprognostic (1.24e-1)" "unprognostic (4.07e-2)" "unprognostic (7.42e-2)" "unprognostic (2.49e-1)" "prognostic favorable (4.35e-4)" "unprognostic (1.18e-1)" "unprognostic (1.96e-1)" "unprognostic (1.52e-1)" 6.8 4.8 5.7 5.4 5.5 3.9 7.3 5.2 6.5 4.6 2.5 7.9 7.7 5.5 4.2 6.3 4.6 3.5 5.5 5.3 5.0 9.6 12.1 3.9 4.0 4.7 4.5 3.7 10.7 5.2 2.5 5.2 4.8 3.6 7.5 4.3 3.3 3.6 16.0 6.5 5.6 5.9 3.9 3.9 5.1 3.2 5.1 2.7 7.1 20.4 4.5 5.5 3.5 5.7 26.0 14.5 13.0 21.1 20.7 17.9 28.6 19.1 15.9 23.4 19.5 18.2 9.0 59.4 12.7 11.4 29.6 19.5 31.9 27.1 30.4 18.4 31.9 49.9 22.5 20.9 25.5 49.7 16.4 19.8 23.5 26.6 33.0 10.3 16.3 16.6 46.5 10.0 17.9 17.3 17.0 25.3 57.7 27.7 40.8 32.9 44.6 43.2 20.7 25.9 29.2 15.4 27.9 35.0 36.3 18.3 20.5 33.4 18.2 18.3 24.0 25.5 26.7 21.2 57.0 27.2 8.5 35.4 15.2 1.6 2.9 0.4 1.1 4.3 1.5 1.8 1.2 1.1 3.0 0.7 1.0 1.1 0.6 1.1 2.2 1.1 0.7 1.6 5.7 5.5 5.2 6.5 5.3 5.0 4.7 4.5 4.8 3.9 5.1 5.7 6.0 6.4 12.4 0.7 4.5 11.5 31.2 7.1 9.6 8.8 6.1 5.2 13.2 10.0 7.1 3.7 4.2 17.1 1.7 11.4 27.4 11.9 0.5 3.2 12.3 8.8 2.4 5.5 1.6 13.3 17.0 7.8 5.1 3.4 0.0 8.0 3.6 13.7 13.7 16.8 2.1 7.0 6.1 4.7 3.5 0.8 7.5 7.0 1.8 1.9 8.7 6.8 4.1 3.5 1.5 11.0 7.0 7.5 9.9 19.3 5.0 20.1 2.6 10.2 6.6 11.4 14.0 4.6 13.0 9.7 12.9 16.6 4.2 10.5 10.5 17.8 COASY "DPCK, NBP, PPAT" ENSG00000068120 "Coenzyme A synthase" Q13057 17 42561467-42566277 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Coenzyme A biosynthesis" "Kinase, Multifunctional enzyme, Nucleotidyltransferase, Transferase" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022875, HPA022912, HPA023273" Approved "Intracellular and membrane" NA NA 20000 "Cluster 44: Non-specific - Transcription" "Cluster 18: Non-specific - Mitochondria" "Cluster 16: U-266 - Nucleosome" "Cluster 40: Granulosa cells - Unknown function" "HPA022875: AB_1847066, HPA022912: AB_1847067, HPA023273: AB_1847068" "unprognostic (2.83e-1)" "unprognostic (8.35e-2)" "unprognostic (1.81e-1)" "prognostic favorable (2.15e-4)" "unprognostic (1.01e-1)" "unprognostic (5.72e-2)" "prognostic unfavorable (7.54e-5)" "unprognostic (4.06e-2)" "unprognostic (3.36e-2)" "unprognostic (2.50e-2)" "unprognostic (1.50e-1)" "unprognostic (7.83e-2)" "unprognostic (1.11e-2)" "unprognostic (2.49e-2)" "unprognostic (5.55e-1)" "unprognostic (1.62e-1)" "unprognostic (2.16e-1)" 27.4 60.0 24.0 23.1 24.0 29.5 32.8 24.7 28.1 27.6 26.7 35.6 43.3 25.2 17.2 54.4 29.8 16.9 29.4 25.4 23.9 45.6 70.9 30.3 25.0 27.8 24.7 26.0 59.0 39.0 30.3 25.5 28.1 32.4 24.3 13.3 58.5 28.7 38.6 46.6 36.9 17.2 23.8 35.9 47.2 32.4 25.7 27.6 39.0 25.3 25.2 26.8 31.1 24.6 94.2 149.1 27.2 55.2 55.5 34.8 89.2 38.3 52.9 65.8 46.5 85.7 89.2 52.7 65.6 50.4 69.5 146.9 66.1 81.4 43.7 47.6 122.2 52.5 91.2 140.9 70.2 56.4 73.1 51.5 97.8 62.4 66.6 52.4 63.2 70.5 98.7 70.8 46.6 59.2 71.5 87.2 36.7 125.8 75.1 39.1 93.5 88.1 89.9 66.7 63.3 50.1 34.9 37.3 75.4 52.2 158.0 70.4 41.6 68.3 62.3 52.4 40.1 84.6 127.4 31.0 80.9 55.3 47.5 23.3 29.8 26.8 19.7 31.8 20.5 15.8 15.8 19.1 33.6 15.7 15.7 16.3 19.5 21.0 22.5 23.6 18.1 24.0 24.0 24.0 24.7 28.1 25.4 23.9 27.8 24.7 28.1 23.8 25.7 24.6 15.4 6.4 23.8 9.8 24.1 15.0 21.7 49.5 25.6 17.8 38.2 22.9 22.9 40.0 33.3 71.7 0.0 89.4 21.2 53.7 33.2 44.8 4.4 31.5 20.6 20.6 17.4 30.3 5.6 52.5 51.6 18.7 40.2 28.0 10.2 101.2 23.9 94.2 40.3 33.7 5.7 36.7 42.7 23.6 16.1 7.7 14.9 19.9 14.2 4.7 36.2 29.4 20.6 3.5 5.9 38.9 32.4 16.6 25.3 31.2 66.3 94.8 36.5 18.0 26.3 15.2 18.6 46.7 31.1 33.4 17.8 77.2 16.9 36.6 45.1 30.7 COCH "COCH-5B2, DFNA31, DFNA9" ENSG00000100473 Cochlin O43405 14 30874514-30895065 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins, Transporters" Hearing "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 7 "pancreas: 502.0" "Cell type enhanced" "Detected in many" "Exocrine glandular cells: 63.0;Horizontal cells: 84.1" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in all" "basal ganglia: 71.3" "Group enriched" "Detected in some" 12 "memory B-cell: 38.3;naive B-cell: 17.7" "Lineage enriched" "Detected in many" 17 "B-cells: 38.3" "Cell line enhanced" "Detected in many" "HEK 293: 95.7;Hep G2: 63.8;K-562: 129.1;NB-4: 105.5;SCLC-21H: 111.8" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "basal ganglia: 50.8" HPA065086 Supported Vesicles "Secreted in other tissues" NA NA 160000 "Cluster 19: B-cells - Humoral immune response" "Cluster 25: Pancreas - Digestion" "Cluster 1: K-562 - Erythropoiesis" "Cluster 48: Smooth muscle cells - ECM organization" Vesicles "HPA065086: " "unprognostic (8.36e-3)" "unprognostic (2.51e-2)" "unprognostic (8.61e-2)" "unprognostic (1.64e-2)" "unprognostic (6.48e-2)" "unprognostic (6.53e-2)" "unprognostic (9.61e-2)" "unprognostic (4.03e-1)" "unprognostic (2.11e-2)" "unprognostic (1.40e-1)" "unprognostic (1.27e-2)" "unprognostic (2.91e-3)" "unprognostic (5.42e-3)" "unprognostic (3.92e-2)" "unprognostic (2.80e-2)" "unprognostic (1.03e-1)" "unprognostic (1.72e-1)" 3.2 3.7 7.3 2.8 71.3 4.0 3.4 1.4 20.9 17.4 19.0 3.2 0.8 0.6 2.2 0.9 6.2 2.9 1.9 5.6 8.0 5.2 0.5 0.6 11.0 2.9 7.9 0.8 502.0 3.4 10.1 1.9 3.7 48.3 2.2 12.1 3.6 73.4 1.3 15.2 2.6 1.1 6.2 2.6 1.7 5.2 12.5 1.3 1.3 5.0 7.7 2.0 23.0 1.7 0.0 35.3 3.1 0.0 0.6 0.1 21.8 0.2 0.0 6.4 17.1 20.9 1.2 0.4 1.7 0.0 1.3 0.1 22.2 0.0 10.6 0.0 95.7 18.1 7.6 63.8 0.0 1.8 7.3 1.3 0.0 0.6 0.0 0.0 0.3 39.9 129.1 5.1 1.6 0.8 9.2 105.5 11.9 0.1 3.7 26.7 0.0 0.9 1.1 3.4 111.8 30.4 2.6 0.6 0.2 12.1 0.0 48.7 0.9 0.0 0.0 0.3 0.1 5.7 15.8 11.2 0.0 0.0 4.7 0.0 0.6 0.0 0.0 0.0 0.0 38.3 0.3 0.0 0.1 17.7 0.0 0.1 0.2 0.0 0.0 0.0 2.2 1.0 7.3 71.3 1.4 20.9 5.6 8.0 2.9 7.9 3.7 6.2 12.5 1.7 2.0 0.0 0.5 3.6 13.4 19.1 2.3 0.3 0.0 2.7 7.9 1.5 0.8 2.8 0.9 0.0 4.2 6.5 1.3 0.6 1.9 0.5 1.5 2.2 0.8 3.1 17.0 7.4 14.3 63.0 14.3 22.0 1.1 1.0 1.3 1.8 5.0 5.0 3.8 84.1 24.2 0.3 6.1 5.0 25.2 2.0 1.5 2.4 19.6 7.5 2.8 14.5 0.0 6.0 16.5 3.7 4.3 6.0 10.0 3.5 0.2 11.7 0.5 4.0 0.0 2.8 9.0 22.1 20.3 0.1 13.5 6.6 3.3 0.1 0.6 1.7 COL11A1 "CO11A1, COLL6, DFNA37, STL2" ENSG00000060718 "Collagen type XI alpha 1 chain" P12107 1 102876467-103108872 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Cancer-related genes, Cataract, Deafness, Disease variant, Dwarfism, Ectodermal dysplasia, Non-syndromic deafness, Stickler syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "placenta: 20.1;retina: 9.6" "Cell type enhanced" "Detected in some" "Astrocytes: 83.9;Excitatory neurons: 99.5;Oligodendrocyte precursor cells: 557.4;Theca cells: 139.6" "Cancer enhanced" "Detected in many" "breast cancer: 27.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 116.9;BJ: 43.2;BJ hTERT+ SV40 Large T+ RasG12V: 85.3;HBF TERT88: 48.7;HSkMC: 142.5;SuSa: 60.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA058335 Approved "Endoplasmic reticulum" "Secreted to extracellular matrix" No No 640000 "Cluster 28: Placenta - Pregnancy" "Cluster 12: NES - Nervous system development" "Cluster 68: Oligodendrocytes - Mixed function" "Endoplasmic reticulum" "HPA058335: AB_2683682" "unprognostic (2.60e-3)" "unprognostic (6.61e-4)" "unprognostic (9.58e-2)" "unprognostic (5.06e-5)" "unprognostic (2.83e-1)" "unprognostic (2.85e-2)" "unprognostic (6.03e-3)" "unprognostic (2.23e-3)" "unprognostic (9.08e-2)" "unprognostic (1.21e-1)" "unprognostic (1.12e-2)" "unprognostic (1.94e-2)" "unprognostic (3.01e-12)" "unprognostic (1.27e-2)" "unprognostic (3.53e-1)" "unprognostic (3.54e-2)" "unprognostic (2.32e-2)" 0.6 0.6 4.3 0.3 3.1 0.0 0.4 1.6 4.6 0.9 2.8 0.4 0.1 0.5 0.1 0.0 0.0 3.1 0.0 2.4 2.5 0.1 0.0 0.3 0.1 2.5 3.7 0.6 0.7 0.2 3.3 20.1 2.2 0.2 0.3 9.6 1.5 0.8 0.1 1.4 0.1 0.3 1.0 0.5 0.1 1.4 2.2 0.0 0.1 0.1 0.0 0.2 0.1 2.1 0.0 0.8 116.9 0.0 4.6 5.9 0.0 43.2 16.1 23.3 85.3 0.0 0.0 0.0 0.1 0.7 0.0 0.0 0.0 0.0 48.7 0.0 0.0 0.0 0.0 0.0 12.2 0.0 0.0 142.5 0.0 1.1 0.0 17.7 0.0 0.0 0.0 0.0 31.6 0.0 0.0 0.0 8.1 0.0 0.1 0.0 7.4 0.0 15.2 0.0 0.1 0.0 0.0 0.1 0.0 60.5 0.0 0.1 0.0 0.6 27.0 0.0 4.7 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.3 3.1 1.6 4.6 2.4 2.5 2.5 3.7 2.2 1.0 2.2 2.1 0.0 0.0 2.2 83.9 0.0 1.8 0.0 0.0 0.0 9.4 0.1 4.2 0.5 0.0 1.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 21.0 0.1 0.9 2.2 0.0 0.0 99.5 0.0 0.8 18.7 0.0 0.0 2.5 8.3 0.0 0.0 0.3 0.0 32.9 0.0 0.0 0.0 1.3 4.0 1.2 0.2 10.6 29.0 0.0 29.8 0.0 557.4 6.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.9 2.6 0.5 0.8 0.0 1.1 0.3 0.2 139.6 0.0 0.0 COL11A2 "DFNA13, DFNB53, HKE5" ENSG00000204248 "Collagen type XI alpha 2 chain" P13942 6 33162681-33192499 "Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Deafness, Disease variant, Dwarfism, Non-syndromic deafness, Stickler syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "pituitary gland: 23.5;testis: 8.1" "Cell type enhanced" "Detected in some" "Astrocytes: 8.5;Early spermatids: 10.8;Muller glia cells: 5.2;Oligodendrocytes: 6.7" "Cancer enriched" "Detected in many" 8 "melanoma: 13.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "Secreted to extracellular matrix" NA NA 2100000 "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 29: Early spermatids - Spermatogenesis" "unprognostic (4.62e-1)" "unprognostic (8.69e-2)" "unprognostic (1.65e-4)" "unprognostic (5.15e-3)" "unprognostic (1.14e-1)" "unprognostic (1.69e-1)" "unprognostic (1.04e-2)" "unprognostic (9.67e-2)" "unprognostic (2.05e-2)" "unprognostic (4.47e-2)" "unprognostic (1.22e-1)" "unprognostic (3.41e-3)" "unprognostic (2.26e-6)" "unprognostic (8.27e-2)" "unprognostic (2.17e-1)" "unprognostic (1.88e-1)" "unprognostic (5.96e-2)" 1.0 0.3 0.3 0.0 0.6 0.0 0.9 0.5 0.6 1.6 0.0 0.7 0.2 1.2 0.2 0.5 0.9 0.1 1.8 0.3 0.3 1.3 0.8 1.0 0.0 0.5 0.4 1.1 0.6 0.1 23.5 0.0 0.5 1.3 0.0 0.1 0.8 0.1 1.3 0.6 0.7 0.1 0.5 1.2 0.7 8.1 0.5 0.3 3.5 0.7 0.0 0.6 0.9 0.8 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.4 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.2 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.3 0.1 0.0 0.2 0.2 0.0 0.0 0.6 0.5 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.6 0.5 0.6 0.3 0.3 0.5 0.4 0.5 0.5 0.5 0.8 2.6 0.0 0.0 8.5 0.1 1.5 0.2 0.1 1.8 2.8 1.2 1.8 2.3 0.0 0.1 0.0 4.2 0.0 0.6 0.3 0.0 0.1 10.8 0.2 0.6 1.5 0.0 0.0 4.2 0.0 0.0 0.3 0.0 0.5 0.0 0.6 4.6 0.2 0.2 0.0 3.7 0.1 0.0 0.6 0.4 1.9 0.0 0.3 1.8 1.0 0.0 5.2 0.0 3.5 6.7 0.1 0.6 0.4 0.8 0.2 0.0 0.1 0.0 1.1 0.0 0.7 1.8 0.9 2.1 0.7 1.1 0.0 0.4 0.2 0.5 0.1 COL13A1 ENSG00000197467 "Collagen type XIII alpha 1 chain" Q5TAT6 10 69801880-69964275 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion, Differentiation, Osteogenesis" "Developmental protein, Heparin-binding" "Congenital myasthenic syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "epididymis: 30.4" "Cell type enhanced" "Detected in some" "Fibroblasts: 10.1;granulocytes: 20.3;Melanocytes: 5.4;Microglial cells: 6.5;NK-cells: 9.2;Smooth muscle cells: 5.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ: 63.6;BJ hTERT+: 61.6;hTERT-RPE1: 83.7;HUVEC TERT2: 102.2;PC-3: 93.1;TIME: 137.4" "Low region specificity" "Detected in single" "Not detected" "Not detected" HPA050392 Approved NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 30: Epididymis - Antimicrobial activity" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 48: Smooth muscle cells - ECM organization" "HPA050392: AB_2681110" "unprognostic (2.79e-2)" "unprognostic (2.82e-3)" "unprognostic (1.38e-1)" "unprognostic (3.86e-1)" "unprognostic (4.67e-4)" "unprognostic (3.13e-1)" "unprognostic (1.69e-1)" "unprognostic (7.43e-2)" "unprognostic (6.16e-3)" "unprognostic (1.22e-1)" "unprognostic (2.60e-1)" "unprognostic (2.53e-2)" "unprognostic (1.36e-5)" "unprognostic (2.66e-1)" "unprognostic (2.32e-1)" "unprognostic (1.52e-2)" "unprognostic (3.93e-2)" 1.2 1.9 1.5 2.6 1.7 0.3 2.0 9.5 3.3 5.7 1.9 4.6 2.9 1.8 30.4 1.9 2.8 2.4 3.4 1.4 1.5 2.0 0.8 10.9 0.9 1.6 1.6 0.9 2.1 0.8 3.7 1.7 1.8 13.6 3.4 0.0 0.7 8.0 0.9 5.2 3.8 2.9 1.6 8.0 6.2 0.7 1.7 0.3 1.5 1.4 0.8 3.8 1.8 1.5 1.5 0.6 22.1 0.0 0.1 4.3 0.1 63.6 61.6 10.9 5.5 0.0 1.4 0.2 10.5 30.1 1.0 2.3 0.0 0.2 18.9 0.0 1.6 0.0 0.0 0.0 2.9 0.0 0.1 9.8 0.1 27.5 9.0 83.7 102.2 0.0 0.0 0.1 10.4 0.4 0.0 0.2 5.3 0.0 93.1 0.1 0.0 10.3 0.4 0.0 2.4 0.0 0.0 0.2 3.4 0.9 0.0 0.2 137.4 0.3 17.1 5.7 45.7 13.4 0.0 0.1 37.2 0.1 51.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 1.5 1.7 9.5 3.3 1.4 1.5 1.6 1.6 1.8 1.6 1.7 1.5 0.9 0.0 0.6 0.3 0.0 3.4 0.3 0.3 0.6 0.2 0.1 2.0 2.1 0.0 0.5 0.0 0.0 0.0 1.2 0.0 0.0 1.3 0.0 0.0 0.2 3.4 0.0 0.0 1.4 0.0 0.0 10.1 0.0 0.1 20.3 1.8 1.1 0.0 0.1 0.0 0.3 0.0 0.0 0.3 2.3 0.0 0.0 0.3 5.4 6.5 0.0 0.1 9.2 0.0 0.3 0.1 0.0 0.4 0.3 0.5 0.9 0.0 0.1 0.0 0.0 1.1 5.6 0.5 0.5 0.2 3.0 0.1 0.6 0.5 0.1 0.1 COL18A1 "KNO, KNO1, KS" ENSG00000182871 "Collagen type XVIII alpha 1 chain" P39060 21 45405165-45513720 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Cell adhesion" "Cancer-related genes, Glaucoma" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 561.9" "Cell type enhanced" "Detected in many" "Hepatocytes: 479.6;Sertoli cells: 223.5;Smooth muscle cells: 268.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "neutrophil: 3.2" "Lineage enriched" "Detected in single" 6 "granulocytes: 3.2" "Cell line enhanced" "Detected in many" "BJ hTERT+: 139.0;EFO-21: 309.4;NTERA-2: 170.6;RPTEC TERT1: 131.6;TIME: 186.0" "Region enriched" "Detected in all" 6 "cerebellum: 22.1" "Low region specificity" "Detected in all" "HPA030933, HPA036104" Supported Approved "Golgi apparatus" "Secreted to extracellular matrix" NA NA 290000000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 85: Liver - Metabolism" "Cluster 38: EFO-21 - Unknown function" "Cluster 48: Smooth muscle cells - ECM organization" "Golgi apparatus" "HPA030933: , HPA036104: AB_2674943" "unprognostic (4.32e-2)" "unprognostic (1.20e-1)" "unprognostic (1.76e-2)" "unprognostic (3.47e-2)" "unprognostic (3.25e-2)" "unprognostic (5.55e-2)" "prognostic favorable (6.16e-4)" "unprognostic (4.23e-3)" "unprognostic (9.93e-2)" "unprognostic (3.48e-1)" "unprognostic (2.77e-1)" "unprognostic (5.50e-2)" "unprognostic (1.70e-1)" "unprognostic (1.83e-2)" "unprognostic (9.44e-2)" "unprognostic (9.10e-3)" "unprognostic (2.25e-3)" 136.4 87.6 14.5 33.9 22.3 15.9 97.1 26.4 21.8 229.4 34.4 91.2 30.4 135.6 35.4 50.1 118.3 28.9 122.2 15.7 18.1 218.2 561.9 83.2 19.8 43.7 28.6 257.3 102.3 7.9 106.5 40.7 39.1 91.0 5.5 5.4 35.8 46.8 26.5 77.8 65.7 28.5 26.6 86.8 44.5 30.0 27.0 9.0 101.1 7.4 7.2 109.8 112.2 45.4 10.5 84.0 20.6 18.0 38.6 31.9 3.3 82.0 139.0 39.1 10.5 48.8 28.9 1.5 309.4 82.8 21.6 37.9 4.6 5.0 7.4 0.7 20.0 47.9 1.4 69.6 37.3 0.7 4.4 37.6 3.3 3.8 4.5 8.5 121.3 0.5 49.6 0.3 14.4 16.7 0.8 3.2 170.6 3.2 30.7 0.7 12.6 4.0 131.6 1.3 22.8 16.3 7.6 7.8 26.6 73.0 7.5 9.9 186.0 0.5 11.4 0.4 17.7 0.4 0.8 1.5 0.1 1.7 32.7 0.8 0.1 0.5 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.5 0.2 3.2 0.0 0.0 0.1 0.0 0.1 14.5 22.3 26.4 21.8 15.7 18.1 43.7 28.6 39.1 26.6 27.0 45.4 156.9 0.0 4.1 6.5 3.9 67.7 15.5 19.0 67.7 13.5 9.3 32.1 15.7 61.5 5.0 112.2 4.2 1.9 3.4 0.1 9.8 117.5 1.5 58.3 99.5 91.2 0.0 33.0 4.9 5.8 1.1 101.1 3.6 144.2 57.8 6.6 75.0 479.6 2.4 0.0 15.8 0.1 4.1 12.1 32.5 6.7 79.9 6.5 49.8 82.4 3.2 141.9 7.2 4.0 28.0 9.9 0.0 126.0 4.6 14.0 0.0 72.9 0.7 6.3 223.5 138.2 268.6 4.1 6.0 7.9 28.6 2.5 15.3 47.5 0.4 2.6 COL25A1 ENSG00000188517 "Collagen type XXV alpha 1 chain" Q9BXS0 4 108808725-109302752 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" Heparin-binding "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 30.0;retina: 24.7;testis: 19.1" "Cell type enhanced" "Detected in some" "Early spermatids: 107.1;Inhibitory neurons: 275.3;Late spermatids: 39.2;Rod photoreceptor cells: 71.5" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 8 "HeLa: 47.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA029107 Approved "Endoplasmic reticulum,Vesicles,Cytosol" NA NA "Cluster 58: Brain - Synaptic function" "Cluster 20: HeLa - Mitochondria" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Vesicles, Cytosol" "Endoplasmic reticulum" "HPA029107: AB_10600802" "unprognostic (1.77e-1)" "unprognostic (2.12e-1)" "unprognostic (1.18e-1)" "unprognostic (8.87e-5)" "unprognostic (2.43e-2)" "unprognostic (3.20e-1)" "unprognostic (7.62e-3)" "unprognostic (6.86e-2)" "unprognostic (2.83e-1)" "unprognostic (3.53e-1)" "unprognostic (1.50e-2)" "unprognostic (1.17e-1)" "unprognostic (5.30e-3)" "unprognostic (2.82e-3)" "unprognostic (9.75e-2)" "unprognostic (1.31e-1)" "unprognostic (1.96e-1)" 6.1 0.5 13.4 0.1 10.3 0.0 2.8 0.0 30.0 1.1 0.3 0.4 2.9 0.6 1.6 0.4 0.9 2.2 0.5 17.8 13.7 1.9 2.2 0.2 0.1 6.5 9.4 1.0 0.2 1.3 7.0 0.3 1.0 0.5 0.3 24.7 4.9 0.5 1.0 0.7 2.5 0.8 6.9 0.8 0.3 19.1 8.9 0.5 2.8 0.3 0.1 0.7 1.0 1.7 0.0 0.0 5.3 0.0 0.0 0.1 0.2 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.2 0.6 0.0 0.0 2.7 0.0 0.1 0.0 3.2 5.9 47.6 0.0 0.0 0.0 0.0 3.3 0.0 0.2 0.0 0.2 0.0 0.1 1.2 0.2 5.6 0.0 0.8 0.0 1.6 0.0 0.1 0.0 2.6 0.0 0.0 0.0 1.1 0.0 0.0 0.2 1.4 5.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 2.8 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.4 10.3 0.0 30.0 17.8 13.7 6.5 9.4 1.0 6.9 8.9 1.7 8.2 0.0 0.0 12.4 0.1 0.0 0.1 0.0 2.2 2.1 0.4 0.6 1.0 0.0 0.6 1.8 4.2 0.0 0.0 0.0 0.0 0.0 107.1 6.5 2.0 1.6 0.0 0.0 20.5 0.0 0.0 0.7 0.0 18.9 0.0 0.5 0.7 0.0 0.0 1.7 275.3 0.0 0.0 0.0 0.4 39.2 0.6 0.2 0.0 10.3 0.0 2.8 0.0 16.6 8.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 71.5 0.0 4.7 24.6 7.8 1.6 0.0 0.1 0.0 0.1 0.3 0.0 0.0 COL2A1 "AOM, SEDC, STL1" ENSG00000139219 "Collagen type II alpha 1 chain" P02458 12 47972967-48004554 "Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted secreted proteins" "Cancer-related genes, Cataract, Deafness, Disease variant, Dwarfism, FDA approved drug targets, Stickler syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "epididymis: 19.1;pituitary gland: 9.2;retina: 5.6;stomach 1: 12.5" "Cell type enhanced" "Detected in some" "Early spermatids: 15.4;Enteroendocrine cells: 43.9;Late spermatids: 9.7;Muller glia cells: 22.6" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 156.3;HAP1: 98.9;HEK 293: 36.3" "Not detected" "Not detected" "Low region specificity" "Detected in some" "CAB002214, HPA055753" Approved Approved Nucleoplasm "Secreted to extracellular matrix" No NA 1400000 "Cluster 68: Epididymis - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 17: Intestinal endocrine cells - Hormone signaling" Nucleoplasm "CAB002214: AB_563666, HPA055753: AB_2682908" "unprognostic (7.25e-2)" "unprognostic (1.20e-1)" "unprognostic (2.58e-1)" "unprognostic (3.44e-1)" "unprognostic (2.88e-2)" "unprognostic (3.08e-2)" "unprognostic (8.63e-2)" "unprognostic (2.77e-1)" "unprognostic (1.22e-1)" "unprognostic (3.12e-2)" "unprognostic (1.31e-4)" "unprognostic (2.64e-1)" "unprognostic (3.44e-3)" "unprognostic (1.89e-1)" "unprognostic (2.93e-1)" "unprognostic (2.07e-1)" "unprognostic (1.02e-1)" 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.1 0.2 0.1 0.0 0.2 0.0 0.2 19.1 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.2 0.0 0.2 0.2 1.3 0.0 0.0 9.2 0.3 0.3 1.0 0.3 5.6 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 12.5 2.8 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 156.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.7 0.0 0.0 0.0 98.9 0.0 0.0 0.0 36.3 0.2 0.0 5.7 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 2.0 0.0 0.1 0.0 2.9 0.0 0.0 0.1 2.2 0.1 0.0 0.0 0.0 11.0 0.0 0.7 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.2 0.2 0.3 0.2 0.2 0.3 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 5.0 0.6 5.7 0.9 0.0 0.0 0.0 0.0 1.8 0.0 0.3 0.0 0.0 15.4 0.3 0.1 0.2 43.9 0.0 0.2 0.0 0.3 0.5 0.0 0.2 0.0 1.3 0.0 0.0 0.2 0.0 0.1 0.6 0.0 0.0 0.0 9.7 0.9 0.0 0.0 0.0 0.0 22.6 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.4 0.2 0.0 1.7 0.0 0.9 0.3 0.6 1.1 0.0 0.0 0.8 0.1 0.1 1.7 0.1 COL4A6 ENSG00000197565 "Collagen type IV alpha 6 chain" Q14031 X 108155607-108439497 "Disease related genes, Human disease related genes, Predicted secreted proteins" "Cell adhesion" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "endometrium 1: 32.6;urinary bladder: 40.7" "Cell type enhanced" "Detected in some" "Basal prostatic cells: 24.5;Basal respiratory cells: 16.0;Cardiomyocytes: 13.1;Prostatic glandular cells: 12.1;Urothelial cells: 15.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HBEC3-KT: 46.0;HeLa: 40.1;HHSteC: 59.2;hTERT-HME1: 44.1;HUVEC TERT2: 41.7;TIME: 94.2" "Low region specificity" "Detected in single" "Low region specificity" "Detected in many" HPA065393 Approved "Endoplasmic reticulum" "Secreted to extracellular matrix" NA NA "Cluster 89: Fibroblasts - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 22: Epithelial cell types - Mixed function" "Endoplasmic reticulum" "HPA065393: AB_2685483" "unprognostic (8.47e-3)" "unprognostic (4.50e-3)" "unprognostic (9.75e-3)" "unprognostic (9.80e-3)" "unprognostic (1.18e-1)" "unprognostic (5.99e-2)" "unprognostic (1.78e-2)" "unprognostic (3.78e-2)" "unprognostic (1.72e-1)" "unprognostic (9.84e-2)" "unprognostic (1.40e-2)" "unprognostic (4.11e-2)" "unprognostic (1.26e-1)" "unprognostic (1.32e-2)" "unprognostic (2.06e-1)" "unprognostic (8.54e-3)" "unprognostic (3.51e-1)" 3.0 0.5 0.3 0.4 0.3 0.0 2.0 0.2 0.2 12.6 1.3 1.9 1.4 32.6 17.0 5.5 14.9 13.3 5.4 0.3 0.7 4.2 0.1 1.0 0.1 0.9 1.7 9.3 0.1 5.5 7.2 3.2 1.0 12.5 2.1 1.2 1.4 21.5 1.4 6.5 1.5 24.5 0.4 1.4 13.3 1.2 0.3 0.9 0.7 1.2 0.1 40.7 9.2 0.6 0.1 31.1 9.9 0.0 24.2 1.7 0.0 0.0 1.8 0.3 0.2 17.9 0.0 0.0 0.0 0.0 3.9 5.8 10.3 46.0 0.8 0.4 8.8 0.8 40.1 0.3 59.2 0.0 0.0 2.6 27.8 6.5 44.1 0.1 41.7 0.0 0.0 0.0 0.6 0.0 0.0 0.0 14.0 0.0 3.8 0.0 0.0 0.0 1.9 3.4 0.0 0.0 2.4 0.0 0.0 18.2 0.9 0.0 94.2 0.0 0.1 5.5 0.1 0.0 0.0 0.0 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.2 0.2 0.3 0.7 0.9 1.7 1.0 0.4 0.3 0.6 0.1 0.0 0.0 6.2 0.0 6.4 24.5 16.0 3.4 0.2 2.3 6.1 13.1 0.0 2.6 1.8 0.0 0.1 0.0 0.0 1.9 0.0 2.1 0.7 6.0 0.4 0.0 0.0 0.4 0.0 0.0 6.2 0.0 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.4 0.0 2.0 0.0 0.3 0.3 4.1 0.0 0.0 8.4 0.0 5.5 0.0 0.0 0.6 0.1 0.0 9.1 0.0 12.1 0.0 0.0 2.2 0.4 0.0 0.4 7.2 0.2 0.2 0.1 3.7 0.0 0.1 0.8 0.0 15.2 COL6A3 ENSG00000163359 "Collagen type VI alpha 3 chain" P12111 2 237324003-237414207 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Cell adhesion" "Protease inhibitor, Serine protease inhibitor" "Congenital muscular dystrophy, Disease variant, Dystonia, Limb-girdle muscular dystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "smooth muscle: 391.3" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 355.2;Fibroblasts: 567.9;Leydig cells: 315.1;Smooth muscle cells: 197.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 3311.7;ASC TERT1: 4227.5;BJ hTERT+: 1279.6;HSkMC: 2705.3" "Region enhanced" "Detected in some" "basal ganglia: 4.5" "Region enriched" "Detected in many" 4 "spinal cord: 12.0" "HPA010007, HPA010080" Supported Approved "Endoplasmic reticulum,Vesicles" "Secreted to extracellular matrix" NA NA 1000000000 "Cluster 46: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Endoplasmic reticulum" Vesicles "HPA010007: , HPA010080: AB_1078550" "unprognostic (8.94e-2)" "unprognostic (7.24e-2)" "unprognostic (6.60e-2)" "unprognostic (3.82e-1)" "unprognostic (3.90e-2)" "unprognostic (2.37e-1)" "unprognostic (5.34e-2)" "unprognostic (2.87e-2)" "unprognostic (8.20e-3)" "unprognostic (2.55e-2)" "unprognostic (1.33e-2)" "unprognostic (1.23e-1)" "prognostic unfavorable (5.57e-11)" "unprognostic (1.54e-2)" "unprognostic (2.50e-2)" "unprognostic (3.51e-2)" "unprognostic (1.84e-3)" 150.8 8.3 0.1 126.5 1.0 0.4 74.5 0.2 3.0 212.6 5.2 94.8 22.9 156.3 10.2 44.1 91.8 236.4 61.2 2.4 0.1 5.7 10.3 65.8 30.7 0.6 0.1 123.8 21.1 17.3 2.8 132.9 0.7 47.7 51.7 0.0 45.2 55.4 32.5 35.7 46.6 391.3 0.8 19.0 41.5 15.6 1.8 24.8 38.1 62.3 16.1 188.4 62.7 0.9 0.2 0.5 0.6 0.0 3311.7 4227.5 60.9 815.6 1279.6 167.0 188.2 0.0 0.1 4.5 0.1 818.7 67.4 0.6 0.7 0.9 98.8 2.0 0.1 0.0 0.0 0.0 669.9 0.0 0.4 2705.3 0.0 596.3 1.8 7.8 0.2 0.0 0.1 0.6 6.2 0.0 0.1 0.2 0.5 0.0 7.4 0.0 0.1 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.4 17.3 0.0 0.4 2.9 19.0 45.1 27.6 142.4 1.0 0.0 0.1 859.2 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.0 0.2 3.0 2.4 0.1 0.6 0.1 0.7 0.8 1.8 0.9 48.2 0.0 10.5 0.3 0.6 61.1 0.5 0.5 1.8 1.0 2.5 2.9 10.6 1.5 3.8 0.0 0.0 4.5 1.2 0.0 0.0 0.9 5.4 11.0 355.2 17.6 0.0 0.0 0.8 0.0 6.2 567.9 6.6 8.7 1.3 1.8 25.4 1.8 8.1 0.0 0.4 0.0 0.0 1.3 85.4 9.6 315.1 5.5 72.9 29.0 2.2 1.1 1.0 0.0 0.3 2.4 0.0 103.4 2.0 0.9 0.0 0.2 1.0 2.3 32.9 19.2 197.7 1.5 1.3 3.3 61.5 5.7 9.3 48.7 0.0 1.0 COL8A2 "FECD, FECD1, PPCD, PPCD2" ENSG00000171812 "Collagen type VIII alpha 2 chain" P25067 1 36095239-36125222 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" "Angiogenesis, Cell adhesion" "Corneal dystrophy, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in some" "Breast myoepithelial cells: 10.2;Cardiomyocytes: 13.5;Fibroblasts: 13.4;Macrophages: 6.8;Melanocytes: 7.2;Microglial cells: 8.4;Sertoli cells: 6.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ: 5.8;fHDF/TERT166: 4.3;HHSteC: 14.1;hTERT-RPE1: 18.2;THP-1: 4.7" "Low region specificity" "Detected in many" "Region enhanced" "Detected in some" "spinal cord: 3.6" HPA049788 Uncertain Uncertain "Golgi apparatus" "Secreted to extracellular matrix" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 33: Fibroblasts - ECM organization" "Golgi apparatus" "HPA049788: AB_2680882" "unprognostic (9.98e-2)" "unprognostic (3.26e-2)" "unprognostic (2.51e-2)" "unprognostic (8.41e-3)" "unprognostic (8.76e-2)" "prognostic favorable (9.44e-4)" "unprognostic (1.15e-1)" "unprognostic (1.75e-1)" "unprognostic (1.17e-1)" "prognostic unfavorable (7.26e-4)" "unprognostic (3.50e-2)" "unprognostic (3.01e-1)" "prognostic unfavorable (9.35e-5)" "unprognostic (1.08e-2)" "unprognostic (6.77e-2)" "unprognostic (2.24e-2)" "unprognostic (1.16e-3)" 5.2 1.2 2.5 4.4 2.2 0.5 5.6 6.1 2.4 9.0 18.3 5.9 1.4 5.7 1.6 5.8 4.2 4.8 5.4 2.3 2.9 1.1 0.6 4.6 3.1 9.0 4.2 3.3 0.8 0.7 4.0 12.8 7.1 6.1 2.0 0.4 7.4 11.4 0.6 5.5 2.4 3.7 6.1 8.5 9.1 0.9 4.2 4.9 7.5 2.1 3.5 13.3 5.9 5.7 0.0 0.0 0.0 0.0 0.5 1.0 0.1 5.8 1.7 1.6 0.9 0.2 0.1 0.0 0.8 4.3 0.0 0.3 0.0 0.1 1.2 0.0 0.0 0.0 0.1 0.1 14.1 0.0 0.0 1.7 0.1 0.7 0.0 18.2 0.6 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.3 0.0 0.4 0.1 0.1 0.0 0.5 0.5 0.5 0.0 0.2 0.4 0.0 4.7 0.1 2.3 0.3 0.4 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 2.5 2.2 6.1 2.4 2.3 2.9 9.0 4.2 7.1 6.1 4.2 5.7 0.6 0.0 1.8 0.3 0.0 2.2 2.2 1.8 0.0 0.1 1.3 10.2 13.5 0.0 0.7 0.0 0.0 0.4 1.4 0.0 0.0 0.4 0.1 0.2 0.2 0.7 0.0 0.0 0.2 0.2 0.3 13.4 0.5 0.3 2.5 0.5 1.1 0.0 6.2 0.0 0.4 0.0 0.0 2.0 2.7 0.2 3.1 6.8 7.2 8.4 1.2 0.3 0.0 0.5 0.1 0.6 0.0 6.0 0.1 5.3 0.0 0.0 0.2 0.2 6.6 0.7 1.4 0.0 0.3 0.1 1.3 0.8 1.2 0.3 0.0 0.4 COLQ EAD ENSG00000206561 "Collagen like tail subunit of asymmetric acetylcholinesterase" Q9Y215 3 15450133-15521751 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" "Neurotransmitter degradation" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 17.9" "Cell type enhanced" "Detected in many" "Astrocytes: 17.3;Excitatory neurons: 45.1;Inhibitory neurons: 46.3;Late spermatids: 16.6;NK-cells: 15.5;Oligodendrocyte precursor cells: 18.1;Oligodendrocytes: 18.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 6 "MAIT T-cell: 60.9" "Lineage enriched" "Detected in many" 34 "T-cells: 60.9" "Group enriched" "Detected in some" 6 "BEWO: 11.5;HDLM-2: 3.8;U-937: 5.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA045876 Approved "Plasma membrane,Cell Junctions" "Secreted to blood" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 28: BEWO - Transcription regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane" "Cell Junctions" "HPA045876: AB_2679479" "unprognostic (4.08e-3)" "unprognostic (2.61e-2)" "unprognostic (2.13e-3)" "unprognostic (2.37e-1)" "unprognostic (2.11e-1)" "unprognostic (4.62e-2)" "unprognostic (1.27e-2)" "unprognostic (1.15e-1)" "unprognostic (1.52e-1)" "unprognostic (1.99e-1)" "unprognostic (1.28e-3)" "unprognostic (4.68e-1)" "unprognostic (7.00e-5)" "unprognostic (6.58e-2)" "unprognostic (1.97e-1)" "unprognostic (1.05e-1)" "unprognostic (1.30e-4)" 2.5 2.3 3.1 0.7 3.2 0.8 2.2 3.9 4.6 4.6 11.9 3.7 1.0 3.4 1.6 0.9 8.8 1.1 17.9 3.7 2.7 2.9 3.4 2.5 3.9 4.8 3.2 3.6 1.7 3.6 5.7 0.3 2.8 4.6 0.5 0.6 1.5 0.8 10.8 1.6 2.6 0.7 2.6 7.2 2.4 5.0 2.3 2.6 2.6 5.1 3.0 2.2 2.4 2.9 0.1 0.0 0.7 0.0 0.0 0.3 11.5 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.2 0.0 0.0 3.8 0.4 0.2 0.5 0.0 0.0 0.1 0.3 0.4 0.0 0.3 0.1 0.2 0.3 0.5 0.0 0.3 0.2 0.2 0.1 0.3 0.0 0.0 0.5 0.2 0.1 0.1 0.1 0.0 0.2 1.0 0.0 0.0 0.2 0.5 0.6 0.0 0.0 0.1 0.2 0.2 0.1 0.8 0.4 0.0 0.0 5.2 0.1 0.0 0.6 0.0 9.9 0.0 60.9 0.0 5.3 7.4 0.0 0.0 0.5 0.6 0.0 1.8 0.0 0.4 0.3 3.5 3.1 3.2 3.9 4.6 3.7 2.7 4.8 3.2 2.8 2.6 2.3 2.9 0.6 0.0 0.6 17.3 0.5 0.3 0.2 0.1 0.0 0.3 0.4 0.6 0.7 0.0 1.4 0.0 0.0 0.3 7.7 0.0 0.0 0.1 4.1 6.5 1.4 0.4 1.2 0.4 45.1 0.0 0.2 0.6 1.1 0.8 0.0 3.3 1.8 0.8 0.2 6.7 46.3 0.2 2.0 0.6 0.0 16.6 1.8 0.4 0.0 7.5 0.4 0.3 15.5 18.1 18.3 0.2 0.1 4.5 2.0 0.2 0.0 0.2 4.3 0.7 0.0 0.5 0.7 1.5 0.5 0.0 0.1 2.3 4.1 1.4 0.3 0.1 COQ2 "CL640, FLJ26072" ENSG00000173085 "Coenzyme Q2, polyprenyltransferase" Q96H96 4 83261536-83284914 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Isoprene biosynthesis, Ubiquinone biosynthesis" Transferase "Disease variant, Neurodegeneration, Parkinsonism, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "tongue: 37.5" "Cell type enhanced" "Detected in many" "Hofbauer cells: 50.7;Kupffer cells: 53.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA056599, HPA068727" Approved Approved Cytosol NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 3: HMC-1 - Innate immune response" "Cluster 12: Non-specific - Cell cycle regulation" Cytosol "HPA056599: AB_2683184, HPA068727: AB_2686022" "unprognostic (8.26e-2)" "unprognostic (7.40e-3)" "unprognostic (3.95e-3)" "unprognostic (1.55e-1)" "unprognostic (9.22e-2)" "unprognostic (5.59e-2)" "unprognostic (1.26e-2)" "unprognostic (1.52e-1)" "unprognostic (4.09e-1)" "unprognostic (4.16e-2)" "unprognostic (2.08e-2)" "unprognostic (2.77e-3)" "unprognostic (1.56e-2)" "unprognostic (3.73e-1)" "unprognostic (1.40e-1)" "unprognostic (7.82e-2)" "unprognostic (2.46e-1)" 6.0 17.0 2.8 8.0 3.2 11.8 5.8 3.5 3.3 7.9 3.6 14.2 9.5 6.3 7.5 10.4 4.4 4.3 15.0 3.0 3.5 5.6 13.6 7.9 6.4 3.6 3.5 6.5 6.5 6.0 4.0 8.4 3.8 6.6 14.2 4.0 7.8 5.0 29.1 10.8 9.1 6.9 4.1 10.1 5.5 3.5 3.9 3.6 5.7 37.5 7.1 7.9 6.5 4.9 26.1 14.7 14.1 27.4 10.5 11.9 9.7 16.1 27.0 29.7 34.4 10.5 38.7 17.2 11.7 28.4 24.6 18.6 23.9 26.0 38.7 17.2 14.8 15.3 22.3 15.4 11.7 31.3 73.5 15.9 16.3 14.2 24.8 8.9 30.7 9.7 10.0 21.4 29.3 27.4 8.6 21.7 10.9 30.6 19.9 14.1 11.4 22.1 45.4 13.8 10.3 6.3 19.0 24.5 9.2 6.7 15.4 18.8 21.0 14.6 14.6 11.1 23.4 5.7 5.2 10.2 29.5 36.8 20.2 2.1 28.8 4.0 2.7 26.8 1.9 6.2 3.0 2.5 21.1 6.9 2.1 3.2 9.8 6.7 33.5 11.2 4.1 13.6 2.8 3.2 3.5 3.3 3.0 3.5 3.6 3.5 3.8 4.1 3.9 4.9 5.4 0.0 4.2 15.7 11.5 6.6 12.4 9.8 4.6 5.9 6.3 5.6 19.5 2.8 10.7 9.2 0.0 25.4 7.1 14.0 31.3 6.7 0.8 7.6 19.5 6.1 4.8 14.1 12.8 10.8 30.0 9.0 6.6 9.2 0.0 17.2 9.3 15.0 50.7 1.7 20.1 15.3 8.2 53.2 7.9 0.8 3.7 25.2 7.2 33.7 21.8 12.6 6.2 25.6 15.6 5.4 15.4 4.9 4.3 12.6 11.0 9.9 6.2 4.8 0.0 7.3 9.7 18.1 19.7 16.7 12.6 12.4 9.6 35.5 26.7 12.9 COQ4 CGI-92 ENSG00000167113 "Coenzyme Q4" Q9Y3A0 9 128322544-128334072 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Ubiquinone biosynthesis" "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Proximal tubular cells: 202.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021406, HPA042945" Supported Supported Mitochondria NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 18: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 49: Ciliated cells - Cilium organization" Mitochondria "HPA021406: AB_2670691, HPA042945: AB_10961047" "unprognostic (9.15e-2)" "prognostic favorable (2.97e-5)" "unprognostic (2.29e-1)" "prognostic favorable (4.93e-6)" "unprognostic (1.60e-1)" "unprognostic (1.46e-1)" "unprognostic (1.25e-1)" "unprognostic (1.04e-1)" "unprognostic (7.51e-2)" "unprognostic (2.11e-1)" "unprognostic (1.31e-3)" "unprognostic (2.89e-2)" "prognostic favorable (5.76e-6)" "unprognostic (6.21e-3)" "unprognostic (1.98e-1)" "unprognostic (1.42e-1)" "unprognostic (5.14e-3)" 23.9 52.9 33.9 21.7 35.3 19.7 28.2 32.9 43.6 31.8 43.1 35.9 76.7 24.9 19.4 62.1 51.8 21.5 39.6 34.8 37.8 62.9 63.8 25.0 24.4 33.4 33.9 30.5 64.1 45.5 53.4 17.6 33.2 41.2 23.7 22.3 47.1 28.3 31.8 56.4 54.1 15.4 32.3 27.5 39.5 22.6 34.3 20.3 51.2 22.6 22.9 31.1 34.1 36.0 36.6 54.4 31.5 36.6 22.4 31.2 58.2 31.7 20.6 40.1 28.0 48.4 46.5 48.6 28.1 24.2 31.6 99.9 27.0 38.0 14.6 25.1 50.5 18.1 112.9 52.9 38.9 51.5 27.0 37.4 45.2 33.6 36.6 21.9 32.4 40.8 121.1 31.5 26.0 106.2 60.5 38.0 37.0 75.1 60.7 60.7 45.2 91.0 49.0 36.9 58.8 40.1 64.7 71.5 41.4 13.8 92.2 18.0 43.3 38.0 35.1 56.9 43.9 53.4 50.4 38.5 47.4 25.0 28.1 22.6 31.1 19.0 44.1 36.4 39.8 39.9 39.4 44.1 39.6 34.4 31.1 38.2 3.8 35.5 37.2 63.7 34.5 29.9 33.9 35.3 32.9 43.6 34.8 37.8 33.4 33.9 33.2 32.3 34.3 36.0 21.3 22.4 29.0 25.8 31.9 28.8 47.1 75.1 47.3 29.9 60.2 65.9 43.0 42.9 48.9 57.0 27.1 90.3 36.5 70.3 142.8 56.4 15.3 139.7 39.8 25.4 31.8 36.0 23.9 63.4 47.5 32.1 35.7 42.2 36.8 37.1 30.0 77.4 49.8 30.3 26.3 65.6 57.0 26.7 23.9 27.4 30.1 24.0 40.9 8.4 27.2 37.4 27.8 17.1 28.8 46.1 66.2 30.9 60.8 32.8 185.3 202.4 161.9 53.3 26.3 27.9 33.4 47.2 31.6 79.4 50.0 47.2 32.3 69.3 85.5 58.0 COQ5 MGC4767 ENSG00000110871 "Coenzyme Q5, methyltransferase" Q5HYK3 12 120503279-120534434 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Ubiquinone biosynthesis" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049487 Approved Uncertain Nucleoli,Mitochondria NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 39: Non-specific - Basic cellular processes" Nucleoli Mitochondria "HPA049487: AB_2680789" "unprognostic (1.46e-1)" "unprognostic (1.99e-2)" "unprognostic (1.32e-1)" "unprognostic (6.30e-3)" "unprognostic (2.00e-1)" "unprognostic (1.66e-1)" "unprognostic (1.88e-1)" "unprognostic (1.60e-1)" "unprognostic (2.01e-2)" "unprognostic (6.20e-2)" "unprognostic (1.62e-1)" "unprognostic (8.37e-2)" "unprognostic (3.79e-2)" "unprognostic (2.02e-1)" "unprognostic (7.73e-2)" "unprognostic (2.00e-2)" "unprognostic (3.88e-2)" 22.7 29.9 22.3 15.9 25.3 11.3 24.1 24.5 29.0 19.7 26.7 24.7 23.4 17.9 23.0 20.4 22.2 14.4 40.7 22.1 23.4 38.9 60.7 15.4 23.3 24.9 24.2 20.5 20.6 21.6 18.1 23.3 24.8 18.9 24.7 26.3 22.4 15.8 98.5 17.6 20.0 18.2 22.8 21.1 19.3 24.7 24.3 22.3 25.7 69.2 23.4 17.2 17.6 29.5 35.7 56.1 49.2 14.2 63.5 48.5 33.7 42.3 27.6 42.5 26.9 22.5 29.2 35.6 48.8 44.7 29.9 37.7 44.2 47.2 43.3 45.4 26.3 47.4 35.0 37.8 51.8 52.2 28.7 46.8 50.2 40.0 46.1 66.0 38.0 67.5 47.4 25.3 49.7 46.9 30.3 60.0 43.2 25.4 43.2 55.9 49.8 52.0 55.2 26.7 37.0 29.8 30.7 15.5 58.3 51.2 77.8 42.6 37.9 29.1 33.4 21.8 28.5 53.9 48.5 40.5 33.3 48.9 35.8 28.6 44.3 32.3 39.7 44.9 39.0 45.6 42.4 43.2 61.0 52.7 56.8 45.5 9.3 60.6 43.5 40.3 57.2 54.4 22.3 25.3 24.5 29.0 22.1 23.4 24.9 24.2 24.8 22.8 24.3 29.5 14.4 12.8 12.8 7.2 15.5 7.8 11.5 33.5 10.8 12.6 17.5 15.2 30.5 18.6 18.1 14.7 14.6 73.0 12.9 16.1 46.9 32.3 59.8 17.8 12.1 15.4 15.0 17.5 5.7 20.0 45.6 16.5 11.7 11.3 17.2 24.0 15.4 42.4 46.3 5.0 7.8 17.0 22.4 12.8 10.1 23.1 16.4 13.6 23.2 3.7 29.0 18.0 23.7 6.6 17.5 11.0 23.9 18.8 11.0 11.2 35.8 66.7 22.4 15.6 6.6 16.3 14.4 34.7 14.8 14.3 8.9 58.3 15.0 32.8 28.1 10.9 COQ6 CGI-10 ENSG00000119723 "Coenzyme Q6, monooxygenase" Q9Y2Z9 14 73949926-73963670 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Ubiquinone biosynthesis" "Monooxygenase, Oxidoreductase" "Deafness, Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 167.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA051371 Uncertain NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 6: T47d - Mammary gland" "Cluster 29: Early spermatids - Spermatogenesis" "HPA051371: AB_2681459" "unprognostic (1.41e-1)" "unprognostic (1.35e-2)" "unprognostic (2.26e-2)" "unprognostic (2.22e-1)" "unprognostic (1.12e-1)" "unprognostic (2.88e-1)" "unprognostic (1.75e-2)" "unprognostic (2.77e-1)" "unprognostic (1.21e-1)" "unprognostic (8.33e-3)" "unprognostic (9.45e-3)" "unprognostic (2.90e-1)" "prognostic favorable (1.05e-6)" "unprognostic (1.19e-1)" "unprognostic (1.94e-1)" "unprognostic (7.46e-2)" "unprognostic (1.89e-1)" 11.2 38.4 10.5 5.6 11.0 5.5 12.0 10.9 13.1 12.1 15.5 13.0 10.2 10.0 11.3 10.1 10.5 6.7 32.0 10.8 11.1 23.0 25.7 7.4 6.3 10.6 10.6 11.5 7.0 25.1 15.9 8.0 10.6 12.6 9.5 5.8 11.1 9.9 38.6 9.3 10.8 9.8 10.7 11.3 13.4 22.0 11.0 7.3 12.3 42.6 7.0 13.6 10.5 11.1 12.2 21.7 11.1 25.7 13.2 10.7 15.4 14.8 13.6 21.8 18.4 16.4 21.0 10.7 13.7 15.3 15.0 19.1 16.6 14.8 20.6 16.3 13.3 7.2 12.8 14.3 18.0 7.2 24.9 18.1 19.2 19.9 19.5 14.1 13.9 21.5 6.4 9.6 19.2 33.3 12.4 11.7 4.0 24.8 26.0 11.7 14.1 7.6 22.9 15.2 16.6 8.8 25.2 21.5 14.6 7.2 36.4 13.3 9.4 24.8 22.9 19.0 10.8 8.9 9.0 9.0 13.7 10.6 17.1 5.4 11.3 9.2 11.3 14.2 11.3 10.3 11.2 11.3 12.1 5.3 15.6 9.4 2.3 14.5 13.1 8.9 7.6 8.5 10.5 11.0 10.9 13.1 10.8 11.1 10.6 10.6 10.6 10.7 11.0 11.1 11.9 25.6 25.5 6.2 11.4 4.7 8.1 26.9 6.8 18.9 12.3 12.4 10.3 11.5 23.1 12.9 12.5 26.3 4.1 8.3 19.6 10.8 167.0 14.1 11.0 9.1 4.8 7.4 10.0 10.9 12.6 11.9 12.2 9.9 25.3 13.9 11.4 14.7 16.2 20.2 10.0 9.7 20.3 5.4 4.2 49.5 10.8 7.5 10.6 3.7 9.6 12.0 15.5 5.0 8.4 8.6 8.4 12.4 10.6 6.0 23.3 41.3 15.8 28.1 19.7 10.5 20.5 24.7 21.0 11.5 6.0 23.8 11.9 39.9 9.4 7.1 COQ7 "CAT5, CLK-1" ENSG00000167186 "Coenzyme Q7, hydroxylase" Q99807 16 19067614-19080095 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Ubiquinone biosynthesis" "Monooxygenase, Oxidoreductase" "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "basophil: 40.4;neutrophil: 126.5" "Lineage enriched" "Detected in all" 8 "granulocytes: 126.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA067252, HPA071922" Approved Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 8: Non-specific - Mitochondria" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 45: Enterocytes - Digestion" "Plasma membrane" Nucleoplasm "HPA067252: AB_2685813, HPA071922: AB_2686473" "unprognostic (1.37e-1)" "unprognostic (6.89e-3)" "unprognostic (1.59e-2)" "unprognostic (6.08e-2)" "unprognostic (2.44e-2)" "unprognostic (9.03e-2)" "unprognostic (1.31e-1)" "unprognostic (4.42e-2)" "unprognostic (1.15e-1)" "unprognostic (7.27e-3)" "unprognostic (2.15e-1)" "unprognostic (8.32e-2)" "prognostic favorable (8.23e-12)" "unprognostic (2.19e-1)" "unprognostic (2.76e-1)" "unprognostic (3.14e-2)" "unprognostic (5.27e-2)" 10.2 13.6 10.7 7.0 11.2 4.8 13.4 10.9 11.6 10.8 12.5 14.1 12.4 15.6 12.3 12.4 15.5 10.7 23.4 11.0 10.8 14.1 12.3 10.0 8.3 10.6 11.3 20.0 10.3 24.4 9.7 10.0 11.1 17.7 13.2 14.0 10.4 14.7 45.8 7.9 11.8 11.6 10.4 10.0 12.8 20.9 11.3 10.3 16.2 44.9 8.4 10.3 8.8 13.1 23.5 24.8 21.1 12.4 11.6 12.2 17.7 13.5 11.0 18.0 18.5 15.9 19.1 17.8 63.9 10.4 19.4 24.5 29.6 16.9 13.0 15.2 29.9 9.5 22.8 49.3 14.4 22.9 20.1 10.3 14.6 16.8 12.2 14.8 14.8 20.9 26.4 16.2 12.9 42.4 24.0 18.4 16.1 9.1 13.1 29.0 23.3 22.8 15.7 15.5 30.4 17.4 12.6 27.4 16.2 10.2 25.2 30.7 16.3 19.0 10.9 14.1 19.7 15.0 26.2 19.7 20.4 13.1 12.5 40.4 11.4 17.8 9.9 10.6 9.4 16.3 8.9 8.7 12.6 15.3 12.2 10.8 126.5 12.9 12.3 15.6 6.2 5.6 10.7 11.2 10.9 11.6 11.0 10.8 10.6 11.3 11.1 10.4 11.3 13.1 13.3 16.0 12.6 6.2 35.5 11.0 26.3 20.9 13.6 31.2 18.3 21.1 21.8 31.5 14.9 16.5 39.6 21.2 28.7 38.1 45.0 25.2 14.8 23.7 16.2 16.1 24.0 4.8 6.0 18.0 17.9 14.9 32.1 23.2 25.4 31.1 20.7 11.1 23.3 20.2 8.8 39.0 30.5 29.4 12.9 8.5 18.6 18.8 10.6 4.7 11.6 39.5 8.2 5.0 9.4 13.2 30.4 13.9 11.6 17.8 71.5 23.7 24.4 53.9 19.7 20.0 20.2 81.3 53.1 12.8 12.4 32.2 23.9 38.2 39.8 24.0 COQ8A "ADCK3, CABC1, COQ8, SCAR9" ENSG00000163050 "Coenzyme Q8A" Q8NI60 1 226940286-226987544 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Ubiquinone biosynthesis" "Kinase, Transferase" "Disease variant, Neurodegeneration, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "skeletal muscle: 1165.1;tongue: 484.7" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 21.9;Collecting duct cells: 33.1;Ductal cells: 21.2;Exocrine glandular cells: 32.7;Proximal tubular cells: 24.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HEK 293: 82.0;RPMI-8226: 78.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA061662 Supported Mitochondria NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 7: Non-specific - Mitochondria" Mitochondria "HPA061662: AB_2684578" "unprognostic (6.37e-3)" "unprognostic (2.09e-2)" "unprognostic (2.29e-1)" "unprognostic (9.06e-2)" "unprognostic (8.94e-2)" "unprognostic (2.49e-1)" "unprognostic (4.42e-2)" "unprognostic (3.50e-3)" "unprognostic (1.81e-1)" "unprognostic (4.02e-1)" "unprognostic (4.15e-3)" "unprognostic (8.67e-2)" "unprognostic (2.40e-2)" "unprognostic (9.24e-2)" "unprognostic (2.82e-1)" "unprognostic (8.88e-2)" "unprognostic (2.62e-1)" 63.9 123.8 7.1 10.3 8.0 26.1 35.8 17.3 8.1 16.5 16.1 30.8 29.9 15.9 0.5 32.2 24.6 19.7 123.5 7.1 5.6 14.4 35.7 9.6 12.7 8.9 5.4 34.1 93.8 6.4 5.3 6.5 9.8 18.5 6.4 1.3 32.7 11.7 1165.1 25.1 18.5 7.2 5.9 14.4 52.8 6.7 5.9 8.6 9.4 484.7 4.3 40.8 13.4 11.5 8.0 14.4 3.3 10.3 11.4 7.3 57.7 3.6 2.9 5.2 6.9 23.0 12.8 24.5 17.9 2.4 2.6 9.2 6.9 8.2 0.8 25.5 82.0 16.7 11.2 38.8 2.5 25.8 9.3 14.2 12.2 4.0 5.4 4.9 2.5 24.7 29.4 19.4 0.7 11.0 15.2 37.3 15.5 62.8 29.5 14.9 17.1 78.6 1.6 5.9 59.9 24.2 7.3 28.7 20.6 3.4 15.1 34.8 2.5 5.9 5.3 8.2 13.3 43.0 40.5 13.1 5.3 29.3 6.0 47.7 23.5 68.4 15.8 17.1 15.3 22.2 15.8 14.6 18.6 26.8 21.5 17.0 43.1 21.2 13.6 8.1 21.5 26.0 7.1 8.0 17.3 8.1 7.1 5.6 8.9 5.4 9.8 5.9 5.9 11.5 11.4 3.2 21.9 0.0 5.8 0.0 0.0 0.0 0.0 0.0 18.1 17.1 0.0 0.0 4.3 33.1 0.0 12.2 10.2 0.0 15.6 21.2 0.0 12.3 8.9 5.4 0.0 0.0 0.0 32.7 10.0 6.3 0.0 9.6 13.9 9.8 0.0 0.0 14.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.2 0.0 0.0 11.4 0.0 0.0 0.0 0.0 10.8 0.0 0.0 3.2 0.0 0.0 24.8 2.2 0.0 0.0 0.0 4.4 0.0 0.0 0.0 0.0 7.7 5.2 16.0 0.0 0.0 COQ9 "C16orf49, DKFZP434K046" ENSG00000088682 "Coenzyme Q9" O75208 16 57447425-57461270 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Ubiquinone biosynthesis" "Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 255.4;tongue: 241.0" "Cell type enhanced" "Detected in all" "Distal tubular cells: 217.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040918 Supported Approved Mitochondria,Cytosol NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 8: Non-specific - Mitochondria" "Cluster 25: RPMI-8226 - Immune response" "Cluster 39: Non-specific - Basic cellular processes" "Mitochondria, Cytosol" "HPA040918: AB_10794154" "unprognostic (9.18e-2)" "unprognostic (3.60e-2)" "unprognostic (2.34e-2)" "unprognostic (1.29e-2)" "unprognostic (2.14e-3)" "unprognostic (2.57e-2)" "unprognostic (1.11e-1)" "unprognostic (3.36e-1)" "unprognostic (2.59e-1)" "unprognostic (9.78e-2)" "unprognostic (2.34e-2)" "unprognostic (1.46e-1)" "prognostic favorable (9.03e-11)" "unprognostic (7.40e-2)" "unprognostic (1.51e-1)" "unprognostic (1.71e-1)" "unprognostic (1.23e-2)" 24.3 44.7 21.7 15.1 22.7 10.6 18.0 23.4 26.1 19.6 38.4 48.6 47.3 16.8 16.6 40.0 24.0 19.4 139.7 21.2 22.1 61.3 53.2 14.4 15.6 21.5 21.8 16.6 27.9 79.7 14.9 16.7 20.7 26.2 38.2 11.8 44.1 28.8 255.4 25.2 41.8 28.3 21.3 12.2 35.3 23.8 24.3 18.7 29.2 241.0 17.3 38.2 21.6 21.7 33.6 67.2 18.3 45.8 36.0 27.3 21.3 31.9 25.3 44.8 24.9 41.2 43.0 40.3 59.0 28.8 34.3 70.5 52.8 56.6 28.3 21.4 49.3 27.7 44.2 66.1 39.8 36.1 44.4 45.6 73.7 35.9 68.1 29.8 51.1 35.6 54.7 18.1 27.4 48.6 30.5 26.8 29.6 74.4 90.6 60.8 58.7 104.8 71.3 37.4 56.3 56.7 108.4 103.8 54.9 16.1 59.4 39.5 34.4 32.4 38.9 34.8 40.4 42.9 29.5 48.0 44.4 51.2 37.3 21.0 28.2 23.0 19.5 36.6 20.1 18.8 16.6 17.1 34.4 19.1 17.7 26.0 8.9 24.0 38.2 21.5 25.5 21.9 21.7 22.7 23.4 26.1 21.2 22.1 21.5 21.8 20.7 21.3 24.3 21.7 17.1 12.8 18.9 37.9 15.7 8.4 17.1 55.3 19.9 16.2 21.7 23.1 79.5 45.8 28.7 25.8 16.7 74.7 14.2 68.8 217.2 53.9 37.9 20.4 17.3 17.3 27.6 21.2 21.2 29.3 25.6 20.7 35.7 18.0 7.0 40.7 18.5 53.6 38.8 20.2 24.0 46.6 83.4 16.3 5.4 28.4 21.1 14.1 28.4 7.5 22.7 29.1 14.4 20.6 14.5 27.2 37.0 20.3 15.9 21.5 90.7 114.1 30.0 24.0 13.1 22.6 19.8 66.0 38.8 37.3 11.2 78.7 12.8 91.2 70.2 18.4 COX6A1 COX6A ENSG00000111775 "Cytochrome c oxidase subunit 6A1" P12074 12 120438090-120440737 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins" Oxidoreductase "Charcot-Marie-Tooth disease, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA062394 Approved Supported Mitochondria NA NA 85000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "HPA062394: AB_2684749" "unprognostic (1.18e-1)" "unprognostic (1.03e-2)" "unprognostic (5.10e-2)" "unprognostic (6.16e-2)" "unprognostic (1.47e-1)" "unprognostic (8.78e-2)" "unprognostic (3.33e-1)" "unprognostic (1.34e-1)" "unprognostic (1.09e-1)" "unprognostic (1.13e-2)" "unprognostic (3.22e-2)" "unprognostic (2.82e-1)" "prognostic favorable (6.50e-7)" "unprognostic (2.53e-1)" "unprognostic (1.31e-1)" "unprognostic (5.48e-2)" "unprognostic (2.63e-2)" 353.0 396.5 1004.7 203.3 1040.0 368.0 321.3 1052.0 1305.8 265.4 959.8 597.1 611.5 248.1 273.9 582.2 248.6 231.3 263.9 1030.7 1086.0 664.3 707.1 269.0 273.3 1062.6 1045.6 207.4 373.0 986.0 344.2 193.5 1075.6 282.7 443.1 392.4 373.3 244.3 59.7 372.2 481.2 230.4 995.3 262.3 493.9 224.4 1086.7 327.9 316.1 88.5 255.3 319.6 348.8 1046.6 532.7 1142.5 627.4 653.5 475.4 403.9 755.8 327.1 447.7 585.1 497.2 1388.3 528.9 1115.9 955.5 477.1 442.6 865.0 624.6 737.3 382.3 663.5 1314.3 596.5 594.9 1036.8 434.6 661.9 405.9 487.3 895.5 531.3 632.3 477.0 505.0 801.0 602.9 337.1 494.2 1528.7 965.1 1667.1 566.1 1034.6 1627.5 644.7 414.7 1044.5 945.3 1302.6 822.4 708.6 595.6 589.9 803.5 347.1 1051.4 742.9 373.0 355.0 431.9 370.9 466.8 513.0 791.3 897.5 558.7 643.2 484.9 225.6 347.3 316.4 258.9 353.6 278.9 377.1 305.3 287.3 486.9 296.9 279.3 287.3 297.9 253.7 374.0 516.7 460.6 534.3 1004.7 1040.0 1052.0 1305.8 1030.7 1086.0 1062.6 1045.6 1075.6 995.3 1086.7 1046.6 346.4 397.4 312.4 41.1 355.0 383.3 526.3 1145.7 508.2 238.3 411.3 426.7 124.4 543.3 683.0 774.3 577.6 774.8 289.0 1306.7 1481.1 659.4 207.3 487.3 239.6 311.2 515.7 348.0 26.3 661.9 701.5 304.0 437.3 425.9 272.2 263.9 266.0 971.0 779.3 146.4 38.1 861.7 980.6 376.6 426.0 136.4 302.0 377.7 524.7 19.7 583.9 440.8 332.7 23.6 56.9 726.1 1417.1 265.5 565.2 506.1 1857.6 1701.6 718.9 414.2 341.8 259.0 508.6 455.8 373.7 1155.8 388.0 927.2 341.0 399.5 1049.7 778.9 CP ENSG00000047457 Ceruloplasmin P00450 3 149162410-149221829 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins, Transporters" "Copper transport, Ion transport, Transport" Oxidoreductase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "liver: 1871.4" "Cell type enhanced" "Detected in many" "Club cells: 558.1;Glandular and luminal cells: 406.0;Hepatocytes: 1687.2;Muller glia cells: 720.5;Respiratory ciliated cells: 318.4" "Cancer enhanced" "Detected in many" "liver cancer: 98.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 10 "EFO-21: 318.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001834, CAB008591" Supported "Secreted to blood" NA NA 160000000000 440000000000 "Cluster 62: Liver - Hemostasis" "Cluster 38: EFO-21 - Unknown function" "Cluster 15: Hepatocytes - Hemostasis" "CAB008591: AB_1613734, HPA001834: AB_1078502" "unprognostic (3.58e-1)" "unprognostic (4.24e-1)" "unprognostic (9.61e-2)" "unprognostic (1.80e-2)" "unprognostic (4.14e-2)" "unprognostic (1.02e-2)" "unprognostic (1.06e-1)" "unprognostic (2.97e-2)" "unprognostic (2.07e-1)" "unprognostic (8.75e-2)" "unprognostic (6.03e-2)" "unprognostic (1.70e-1)" "prognostic unfavorable (1.14e-7)" "unprognostic (2.68e-2)" "unprognostic (1.59e-1)" "unprognostic (2.00e-1)" "unprognostic (2.70e-1)" 13.0 2.3 17.9 2.2 18.1 0.9 20.8 18.7 29.8 70.2 129.2 13.0 9.8 14.8 0.0 5.6 8.3 1.1 39.2 17.5 33.0 9.5 1871.4 13.4 18.9 28.1 20.3 0.8 6.5 3.9 28.6 3.4 24.9 7.9 16.4 246.5 39.9 0.9 2.6 13.0 20.8 2.4 19.2 23.1 3.0 1.5 20.1 0.5 16.1 8.3 20.0 23.9 2.3 29.0 0.2 18.8 15.6 0.0 3.3 0.1 0.1 0.0 0.2 0.0 0.0 0.1 0.1 0.1 318.8 0.0 29.4 0.1 0.2 0.0 0.0 0.2 0.2 0.0 0.4 32.7 0.0 0.4 0.0 0.1 0.0 0.0 0.1 0.5 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.2 2.5 5.4 0.0 0.0 0.0 0.4 6.7 16.2 0.0 0.2 0.3 1.0 0.1 0.4 0.0 0.4 0.0 0.2 1.7 0.2 0.2 0.0 0.0 0.9 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 17.9 18.1 18.7 29.8 17.5 33.0 28.1 20.3 24.9 19.2 20.1 29.0 2.3 19.2 76.6 3.3 10.6 3.3 8.3 28.6 0.6 6.9 14.0 0.6 0.6 65.8 558.1 9.2 6.2 0.1 0.3 0.1 0.0 83.4 0.9 190.5 51.0 12.6 0.0 34.7 1.5 21.4 0.2 16.3 0.0 406.0 2.5 0.1 34.6 1687.2 0.6 5.0 1.4 0.2 8.2 44.6 6.9 1.2 0.3 4.0 0.0 6.5 1.6 720.5 1.0 0.5 2.0 69.3 0.0 0.4 0.3 19.5 0.0 0.3 318.4 24.8 0.0 0.8 15.3 0.0 0.1 0.8 2.6 0.3 4.9 0.1 0.1 79.0 CPA6 CPAH ENSG00000165078 "Carboxypeptidase A6" Q8N4T0 8 67422038-67746378 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 2.3;prostate: 2.7;retina: 2.2" "Cell type enhanced" "Detected in some" "Basal prostatic cells: 31.7;Early spermatids: 21.7;Microglial cells: 12.2;Muller glia cells: 22.5;Pancreatic endocrine cells: 21.5;Paneth cells: 12.8;Prostatic glandular cells: 11.3;Urothelial cells: 36.6" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CACO-2: 2.5;EFO-21: 1.5;Hep G2: 3.4;OE19: 1.5" "Region enriched" "Detected in some" 9 "olfactory bulb: 12.6" "Low region specificity" "Detected in all" "Secreted to extracellular matrix" NA NA "Cluster 37: Intestine - Unknown function" "Cluster 39: CACO-2 - Unknown function" "Cluster 22: Epithelial cell types - Mixed function" "unprognostic (2.85e-2)" "unprognostic (1.95e-1)" "unprognostic (1.72e-2)" "unprognostic (1.14e-1)" "unprognostic (2.58e-1)" "unprognostic (2.24e-1)" "unprognostic (2.08e-1)" "unprognostic (2.88e-1)" "unprognostic (9.35e-2)" "unprognostic (1.65e-1)" "unprognostic (5.23e-2)" "unprognostic (6.99e-2)" "unprognostic (3.57e-4)" "unprognostic (9.61e-5)" "unprognostic (1.75e-1)" "unprognostic (9.09e-2)" "unprognostic (1.41e-2)" 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.6 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 2.3 2.2 0.0 0.2 0.0 0.0 0.2 0.8 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.0 1.2 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 1.5 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.0 31.7 0.0 5.7 0.2 0.1 0.4 0.2 0.0 0.1 0.0 0.0 0.0 0.0 2.3 0.0 0.0 21.7 0.1 0.0 0.1 2.4 0.0 1.6 0.4 0.0 0.4 0.0 0.7 0.0 0.0 0.0 0.0 0.1 1.7 1.3 2.2 0.0 0.0 0.0 3.2 1.8 0.2 0.0 12.2 0.1 22.5 0.0 3.0 1.3 21.5 12.8 0.0 0.0 11.3 0.0 0.0 0.0 1.0 0.0 0.1 0.3 0.0 0.0 0.8 0.0 0.0 0.6 0.0 5.7 36.6 CPLX1 CPX-I ENSG00000168993 "Complexin 1" O14810 4 784957-826129 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Exocytosis, Neurotransmitter transport, Transport" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 10 "brain: 273.5" "Cell type enhanced" "Detected in many" "Adipocytes: 45.5;Bipolar cells: 33.4;Endothelial cells: 29.6;Excitatory neurons: 44.2;Inhibitory neurons: 90.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "SCLC-21H: 84.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA071191, HPA074390" Supported Uncertain Vesicles NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 65: Brain - Ion transport" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles "HPA071191: , HPA074390: " "unprognostic (9.21e-3)" "prognostic unfavorable (4.20e-4)" "unprognostic (3.45e-2)" "unprognostic (4.68e-2)" "unprognostic (1.16e-2)" "unprognostic (1.02e-1)" "unprognostic (3.14e-2)" "unprognostic (2.26e-2)" "unprognostic (9.52e-3)" "unprognostic (2.01e-2)" "prognostic favorable (5.05e-4)" "unprognostic (1.10e-3)" "unprognostic (3.32e-1)" "unprognostic (2.05e-2)" "unprognostic (1.12e-1)" "unprognostic (1.34e-1)" "unprognostic (7.77e-2)" 17.2 13.4 26.1 1.2 43.0 0.1 18.2 59.7 273.5 16.9 0.0 5.0 1.0 10.8 0.1 5.7 16.4 0.4 11.5 18.5 72.8 10.9 8.3 9.4 0.8 135.5 25.1 9.4 3.2 1.4 12.8 0.3 128.2 13.8 0.2 5.7 9.6 0.7 4.1 3.4 5.1 0.4 13.9 27.2 4.9 8.6 124.2 3.6 7.5 0.2 0.2 8.3 12.9 89.9 5.7 0.5 0.1 0.8 0.0 0.0 0.3 0.2 0.0 0.0 0.0 16.3 1.7 4.2 1.9 0.0 0.3 0.0 0.4 0.0 0.0 0.0 1.8 0.4 0.0 1.8 0.0 0.0 0.5 0.6 0.0 0.0 0.0 0.0 0.0 2.3 2.0 0.3 0.0 2.5 2.3 0.0 2.6 4.4 2.6 0.1 0.0 1.6 0.0 0.4 84.3 11.8 0.4 5.5 0.0 0.2 8.5 0.3 0.1 0.0 0.5 0.1 0.1 0.2 4.7 0.0 0.1 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 26.1 43.0 59.7 273.5 18.5 72.8 135.5 25.1 128.2 13.9 124.2 89.9 45.5 0.0 0.0 5.9 0.4 1.0 3.2 0.4 1.8 33.4 7.8 8.1 3.6 0.0 1.9 0.0 4.2 0.1 2.8 2.5 1.9 1.2 1.4 1.1 5.4 29.6 21.5 0.0 44.2 0.8 3.2 1.8 2.6 1.4 0.0 0.3 14.3 4.8 0.2 18.5 90.7 2.1 0.0 0.3 1.9 2.3 1.8 0.5 1.8 8.4 0.0 16.8 0.0 8.0 4.7 0.8 5.2 0.0 0.6 2.6 0.3 1.2 0.0 21.7 0.0 0.4 2.3 4.3 9.8 0.2 1.1 1.0 1.6 0.8 2.7 1.3 CPT1C "CATL1, CPT1P, CPTIC, FLJ23809" ENSG00000169169 "Carnitine palmitoyltransferase 1C" Q8TCG5 19 49690898-49713731 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Fatty acid metabolism, Lipid metabolism" "Acyltransferase, Transferase" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 19.2;pituitary gland: 28.4" "Cell type enhanced" "Detected in many" "Bipolar cells: 43.4;Excitatory neurons: 34.0;Horizontal cells: 32.0;Inhibitory neurons: 28.1;Late spermatids: 29.7;Oligodendrocyte precursor cells: 21.1" "Cancer enriched" "Detected in many" 5 "glioma: 9.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 40.2;AN3-CA: 33.2;SCLC-21H: 27.4;SH-SY5Y: 70.1;U-87 MG: 29.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014529, HPA063621" Approved Approved Centrosome NA NA "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 56: Bipolar cells - Visual perception" Centrosome "HPA014529: AB_1847206, HPA063621: AB_2732706" "unprognostic (1.09e-1)" "unprognostic (6.25e-2)" "unprognostic (1.03e-2)" "unprognostic (5.18e-3)" "unprognostic (1.73e-1)" "unprognostic (1.46e-3)" "unprognostic (1.39e-1)" "unprognostic (2.54e-1)" "unprognostic (1.06e-1)" "unprognostic (2.49e-1)" "prognostic favorable (1.84e-4)" "unprognostic (4.36e-1)" "unprognostic (1.92e-10)" "unprognostic (9.44e-4)" "unprognostic (3.35e-2)" "unprognostic (3.91e-1)" "unprognostic (4.72e-3)" 3.4 5.3 14.0 1.6 14.8 0.0 2.1 8.5 19.1 6.5 18.8 2.6 1.3 8.1 2.3 1.0 4.9 4.4 3.8 19.2 15.6 1.7 0.8 2.1 1.3 10.1 9.2 5.1 1.4 1.4 28.4 0.7 10.3 3.4 0.6 12.4 1.0 2.5 0.7 1.0 1.8 4.6 4.9 4.9 1.5 3.5 12.9 0.2 2.4 0.2 0.6 2.7 3.7 14.4 0.0 0.0 40.2 33.2 14.0 11.0 0.0 12.6 25.2 16.2 22.4 0.7 0.0 0.8 0.0 12.7 2.0 3.0 0.0 0.0 8.5 0.6 0.1 0.0 0.1 0.0 22.7 0.0 0.0 12.7 0.0 13.3 0.1 4.3 22.2 0.1 0.1 0.0 0.9 0.7 0.2 0.0 1.8 2.7 8.8 0.0 0.0 0.0 0.9 0.0 27.4 70.1 0.1 0.1 0.0 0.6 0.1 0.1 18.3 1.0 0.2 7.7 6.7 0.2 3.2 0.4 29.5 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.0 14.8 8.5 19.1 19.2 15.6 10.1 9.2 10.3 4.9 12.9 14.4 3.8 0.0 0.0 7.5 0.4 2.2 3.1 0.5 3.4 43.4 0.9 1.3 1.4 1.5 0.0 0.0 16.7 1.1 0.3 0.1 0.0 0.0 8.9 0.5 14.1 7.4 0.0 0.0 34.0 0.0 4.4 6.0 0.0 1.2 0.0 1.9 5.0 0.1 0.3 32.0 28.1 0.1 0.0 0.9 1.2 29.7 3.4 0.8 0.0 7.5 0.0 18.3 0.0 21.1 14.9 0.3 0.0 13.2 1.4 2.1 0.0 0.0 0.0 19.1 0.0 5.8 6.3 3.1 7.0 1.0 1.8 1.1 0.7 4.4 0.2 1.6 CRAT CAT1 ENSG00000095321 "Carnitine O-acetyltransferase" P43155 9 129094142-129111189 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Fatty acid metabolism, Lipid metabolism, Transport" "Acyltransferase, Transferase" Neurodegeneration "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 227.5;tongue: 201.3" "Cell type enhanced" "Detected in many" "Early spermatids: 181.2;Late spermatids: 521.8;Proximal enterocytes: 136.4;Spermatocytes: 123.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019230, HPA020260, HPA022815" Enhanced Approved "Nucleoplasm,Nuclear membrane" NA NA 8100 "Cluster 39: Non-specific - mRNA processing" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 6: T47d - Mammary gland" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Nuclear membrane" "HPA019230: AB_1847212, HPA020260: AB_1847210, HPA022815: AB_2732427" "unprognostic (5.13e-2)" "unprognostic (9.79e-3)" "unprognostic (1.99e-2)" "prognostic favorable (2.36e-4)" "unprognostic (2.19e-1)" "unprognostic (1.14e-1)" "unprognostic (1.15e-2)" "unprognostic (2.18e-1)" "unprognostic (5.11e-2)" "unprognostic (3.24e-2)" "unprognostic (3.13e-3)" "unprognostic (2.03e-1)" "prognostic favorable (0.00e+0)" "unprognostic (1.38e-1)" "unprognostic (9.27e-2)" "unprognostic (1.26e-2)" "unprognostic (7.65e-2)" 36.1 51.3 26.4 5.4 26.6 9.0 29.2 27.0 33.8 31.7 27.5 36.1 33.0 24.8 4.0 37.3 23.1 6.6 68.2 25.1 27.8 46.9 151.2 15.2 3.2 28.8 28.2 23.0 107.1 26.3 12.3 6.6 30.6 42.2 4.2 1.7 32.8 8.9 227.5 29.6 37.2 6.8 26.7 15.2 34.0 146.4 30.2 3.1 21.5 201.3 1.6 31.3 27.5 24.4 0.1 39.3 10.7 21.3 13.4 25.9 17.0 15.0 16.6 18.9 12.0 7.8 14.0 1.5 9.2 25.9 23.2 6.7 2.2 4.9 7.2 23.6 0.3 7.3 19.1 30.4 34.1 0.0 26.1 26.3 0.0 15.7 0.9 15.8 26.2 7.2 3.6 5.7 20.0 9.1 0.5 15.9 2.8 32.0 18.0 16.8 21.8 12.2 18.0 0.6 4.2 12.1 0.0 7.1 4.8 3.4 49.7 5.5 22.6 23.0 1.6 32.1 15.4 25.5 22.6 0.1 28.8 4.2 16.8 1.6 8.4 3.5 3.2 5.5 6.7 1.5 4.4 4.3 8.6 1.3 2.6 3.1 1.1 4.4 5.6 3.9 4.5 6.1 26.4 26.6 27.0 33.8 25.1 27.8 28.8 28.2 30.6 26.7 30.2 24.4 10.5 6.4 3.7 5.5 4.9 3.2 4.7 10.8 0.6 1.5 9.7 8.1 57.8 21.5 8.2 3.7 2.1 45.9 6.0 64.5 17.6 22.6 181.2 3.5 15.7 12.9 15.5 17.4 5.3 22.4 55.6 19.3 16.8 9.9 7.0 12.9 14.6 65.7 20.7 1.7 6.1 23.6 14.2 13.9 10.5 521.8 22.1 12.4 5.4 6.5 8.3 15.5 6.2 3.5 4.0 11.6 47.6 24.5 9.6 9.3 136.4 52.0 2.8 1.3 6.6 10.5 15.7 123.5 8.6 57.4 4.5 50.3 7.6 20.1 29.3 13.8 CRB1 "LCA8, RP12" ENSG00000134376 "Crumbs cell polarity complex component 1" P82279 1 197268204-197478455 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Disease variant, Leber congenital amaurosis, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 21.3;retina: 74.7" "Cell type enhanced" "Detected in some" "Astrocytes: 469.5;Cone photoreceptor cells: 164.7;Inhibitory neurons: 130.1;Muller glia cells: 79.7;Oligodendrocyte precursor cells: 280.0;Oligodendrocytes: 105.6;Rod photoreceptor cells: 149.3" "Cancer enriched" "Detected in single" 12 "glioma: 2.8" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 28 "basophil: 7.7" "Lineage enriched" "Detected in single" 28 "granulocytes: 7.7" "Cell line enriched" "Detected in some" 8 "HeLa: 12.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA061250, HPA063127" Approved Uncertain Vesicles "Secreted in brain" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 20: HeLa - Mitochondria" "Cluster 64: Astrocytes - Nervous system maintenance" Vesicles "HPA061250: AB_2684458, HPA063127: AB_2684944" "unprognostic (1.96e-1)" "unprognostic (5.38e-3)" "unprognostic (2.92e-3)" "unprognostic (1.50e-2)" "unprognostic (5.13e-1)" "unprognostic (3.28e-2)" "unprognostic (2.38e-1)" "unprognostic (2.49e-2)" "unprognostic (1.05e-1)" "unprognostic (1.48e-3)" "unprognostic (2.59e-1)" "unprognostic (2.01e-3)" "unprognostic (1.78e-3)" "unprognostic (1.56e-1)" "unprognostic (3.36e-2)" "unprognostic (2.96e-1)" 0.1 0.1 15.7 0.0 17.6 0.4 0.1 19.8 20.5 0.0 9.6 0.1 0.0 0.0 0.1 0.1 0.4 0.0 0.2 15.8 14.2 0.1 0.0 0.1 0.1 18.7 18.4 0.7 0.4 0.0 2.2 0.0 17.5 0.0 0.0 74.7 0.0 0.0 0.7 0.0 0.0 0.0 18.9 0.0 0.2 2.9 16.1 0.0 0.2 0.5 0.0 0.0 0.0 21.3 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.8 12.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.2 0.0 0.0 0.0 0.0 0.0 15.7 17.6 19.8 20.5 15.8 14.2 18.7 18.4 17.5 18.9 16.1 21.3 0.0 0.0 0.0 469.5 0.0 0.3 0.2 0.3 0.0 15.0 0.2 0.1 1.1 0.0 0.2 0.0 164.7 0.0 0.0 0.0 0.0 0.0 1.9 0.2 0.0 0.7 0.0 11.6 53.2 0.0 0.0 0.2 0.0 0.0 0.0 6.4 0.0 0.0 0.0 1.7 130.1 0.0 2.0 0.0 0.5 1.6 1.8 0.0 0.0 24.4 0.0 79.7 0.0 280.0 105.6 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.9 149.3 0.0 0.2 0.1 1.8 0.3 0.0 0.3 0.0 0.1 0.2 0.0 0.0 CRX "CORD2, CRD, LCA7, OTX3" ENSG00000105392 "Cone-rod homeobox" O43186 19 47819779-47843330 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Differentiation, Neurogenesis, Sensory transduction, Transcription, Transcription regulation, Vision" "Activator, Developmental protein, DNA-binding" "Cone-rod dystrophy, Disease variant, Leber congenital amaurosis, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 136 "retina: 238.5" "Group enriched" "Detected in some" 5 "Bipolar cells: 136.5;Cone photoreceptor cells: 285.7;Rod photoreceptor cells: 501.5" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA036762, HPA036763" Enhanced NA NA "Cluster 11: Basophils - Unknown function" "Cluster 79: Retina - Phototransduction" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA036762: AB_10673663, HPA036763: AB_10670922" "unprognostic (1.09e-2)" "unprognostic (1.25e-2)" "unprognostic (1.58e-1)" "unprognostic (2.56e-2)" "unprognostic (3.22e-2)" "unprognostic (2.69e-1)" "unprognostic (2.77e-2)" "unprognostic (3.71e-1)" "unprognostic (3.82e-2)" "unprognostic (1.33e-2)" "unprognostic (1.95e-10)" "unprognostic (9.27e-2)" "unprognostic (1.82e-2)" "unprognostic (8.94e-2)" "unprognostic (1.78e-3)" 0.0 0.0 0.1 0.0 0.1 0.2 0.0 0.3 0.2 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.6 0.0 0.1 0.0 0.0 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.2 0.0 0.0 238.5 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.4 0.1 0.0 0.1 0.0 0.0 0.1 0.1 0.3 0.2 0.3 0.6 0.1 0.1 0.2 0.0 0.1 0.3 0.8 6.4 14.3 0.0 0.6 0.9 2.3 0.1 0.0 136.5 0.3 0.4 0.5 1.5 13.6 0.0 285.7 0.2 1.7 0.1 0.0 0.0 0.7 0.5 0.5 5.5 0.0 0.0 0.4 0.0 0.2 3.9 0.0 0.8 10.1 0.1 1.8 0.5 0.2 32.0 0.3 0.2 0.0 1.0 1.8 0.5 4.7 2.2 0.0 0.0 0.2 59.3 0.0 0.0 0.1 0.0 0.0 0.7 0.3 1.3 0.2 0.0 9.7 501.5 0.0 0.9 0.3 0.2 0.6 0.0 1.1 0.0 1.3 0.1 0.1 1.7 CRY1 PHLL1 ENSG00000008405 "Cryptochrome circadian regulator 1" Q16526 12 106991364-107093549 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Biological rhythms, Sensory transduction, Transcription, Transcription regulation" "Photoreceptor protein, Receptor, Repressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 108.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB018762 Approved Supported "Nucleoplasm,Nuclear membrane,Microtubules" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Nuclear membrane, Microtubules" "CAB018762: AB_2083970" "unprognostic (1.21e-3)" "unprognostic (4.74e-2)" "unprognostic (6.50e-2)" "unprognostic (9.03e-2)" "unprognostic (1.79e-1)" "unprognostic (2.84e-1)" "unprognostic (3.48e-2)" "unprognostic (3.61e-1)" "unprognostic (4.29e-3)" "unprognostic (1.34e-2)" "unprognostic (6.85e-3)" "unprognostic (2.06e-1)" "unprognostic (1.20e-1)" "unprognostic (1.82e-2)" "unprognostic (5.08e-1)" "unprognostic (1.85e-1)" "unprognostic (2.25e-1)" 13.3 12.4 8.5 7.6 9.8 12.4 11.2 16.2 10.9 11.1 16.7 12.6 11.5 14.2 6.4 11.0 16.4 16.7 11.7 8.4 9.0 13.7 13.6 19.3 5.8 9.8 10.1 9.0 13.5 8.8 8.4 12.1 9.9 11.3 8.6 21.3 9.0 11.5 10.9 9.0 12.7 16.8 9.7 8.7 16.2 37.3 9.9 19.0 17.0 11.0 6.7 15.6 8.6 12.5 17.3 16.9 20.6 23.0 14.6 9.1 36.9 17.9 19.1 36.0 24.2 19.9 10.1 0.0 11.1 16.7 22.7 11.6 26.8 9.3 39.6 17.3 16.6 16.9 15.3 13.8 18.6 17.3 14.2 8.6 9.6 26.4 24.9 17.8 30.5 31.4 19.3 14.6 22.7 12.1 39.2 19.7 25.1 16.5 24.6 34.5 52.3 6.1 25.3 20.2 37.1 19.2 33.6 22.1 10.9 20.0 15.6 9.6 13.5 20.9 22.2 14.6 16.2 26.6 26.6 7.8 10.2 16.3 17.5 12.0 3.2 5.8 12.8 4.7 16.1 1.9 9.6 8.2 4.3 1.9 8.9 8.8 1.4 6.4 8.9 2.8 13.5 5.7 8.5 9.8 16.2 10.9 8.4 9.0 9.8 10.1 9.9 9.7 9.9 12.5 16.3 16.0 16.2 20.5 9.7 69.2 47.9 4.3 55.2 16.8 30.4 14.7 11.1 11.5 6.1 11.0 20.9 8.3 29.1 12.7 17.6 11.4 12.8 27.3 19.3 20.1 19.6 11.2 22.4 16.3 13.4 24.5 45.9 33.2 5.1 6.2 12.1 20.2 6.3 26.9 38.4 9.7 6.1 7.3 21.0 4.8 11.5 8.8 16.0 13.1 16.3 22.8 19.6 35.2 32.8 21.5 7.0 17.3 15.3 29.7 7.7 16.1 18.7 13.7 6.6 24.3 19.2 108.0 32.4 24.3 59.5 15.1 29.7 5.7 6.8 27.0 CRYAA "CRYA1, HSPB4" ENSG00000160202 "Crystallin alpha A" P02489 21 43169008-43172805 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Sensory transduction, Vision" "Chaperone, Eye lens protein" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 11 "kidney: 85.6;retina: 55.5" "Cell type enriched" "Detected in single" 5 "Muller glia cells: 2.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 148 "Hep G2: 38.0" "Region enhanced" "Detected in some" "hippocampal formation: 3.9" "HPA037737, HPA038430" Supported Approved Nucleoplasm,Cytosol NA NA "Cluster 7: Kidney - Transmembrane transport" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 5: Muller glia cells - Visual perception" Cytosol Nucleoplasm "HPA037737: AB_2675639, HPA038430: AB_2732478" "unprognostic (3.68e-3)" 0.0 0.0 0.3 0.0 0.3 0.0 0.0 0.2 0.5 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 85.6 6.6 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 55.5 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.3 0.6 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 38.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.2 0.5 0.3 0.2 0.2 0.1 0.2 0.2 0.3 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CRYAB "CRYA2, HSPB5" ENSG00000109846 "Crystallin alpha B" P02511 11 111908564-111923722 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Chaperone, Eye lens protein" "Cancer-related genes, Cardiomyopathy, Cataract, Disease variant, Myofibrillar myopathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 5623.2;heart muscle: 10683.1;skeletal muscle: 6972.0;tongue: 9406.7" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 2889.5;Cardiomyocytes: 6878.2;Muller glia cells: 1664.3;Proximal tubular cells: 7285.9" "Group enriched" "Detected in all" 6 "glioma: 426.4;renal cancer: 575.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 6 "ASC diff: 2663.1;fHDF/TERT166: 775.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002053, CAB040560, HPA057100" Enhanced Enhanced "Plasma membrane,Cytosol" "Intracellular and membrane" NA NA 370000 "Cluster 39: Non-specific - Mitochondria" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Plasma membrane, Cytosol" "CAB002053: AB_442024, CAB040560: , HPA057100: AB_2683337" "unprognostic (1.06e-2)" "unprognostic (2.26e-1)" "prognostic unfavorable (4.90e-5)" "unprognostic (2.46e-2)" "unprognostic (3.02e-2)" "unprognostic (8.41e-3)" "unprognostic (9.29e-3)" "unprognostic (7.35e-2)" "unprognostic (8.91e-2)" "unprognostic (1.55e-2)" "unprognostic (6.68e-2)" "unprognostic (7.02e-2)" "unprognostic (3.68e-2)" "unprognostic (7.92e-2)" "unprognostic (8.83e-2)" "unprognostic (1.18e-1)" "prognostic unfavorable (1.70e-5)" 1035.0 106.6 2466.0 113.9 3113.8 0.4 592.2 3032.2 5623.2 439.1 2077.7 678.9 24.6 351.4 179.1 312.2 204.0 71.7 10683.1 2424.9 2666.2 2123.2 37.2 253.4 15.0 3215.2 2856.7 136.0 50.6 24.9 209.2 107.8 3147.1 317.9 78.2 478.7 428.7 358.5 6972.0 317.3 158.5 338.1 2877.3 88.5 263.8 23.5 2815.5 20.9 477.7 9406.7 34.4 490.0 477.5 4060.6 0.1 0.5 0.1 45.0 2663.1 90.9 15.0 54.5 2.5 0.8 2.5 1.7 0.2 0.0 41.7 775.8 0.2 2.0 1.8 2.3 1.4 0.3 0.0 0.0 11.9 3.9 16.9 0.4 0.7 77.1 11.1 0.6 6.2 44.3 0.2 0.0 4.6 2.5 169.5 0.1 0.1 1.1 0.5 0.0 1.0 0.2 0.0 0.6 29.8 0.8 0.1 0.4 5.3 9.1 39.8 63.5 4.9 0.0 1.7 310.1 105.0 6.5 4.1 0.5 0.1 0.6 7.1 0.4 39.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2466.0 3113.8 3032.2 5623.2 2424.9 2666.2 3215.2 2856.7 3147.1 2877.3 2815.5 4060.6 38.4 83.3 4.1 96.0 51.3 174.9 2889.5 32.1 72.8 16.2 334.4 696.1 6878.2 84.4 15.2 1338.9 18.8 3.9 6.8 0.4 677.0 320.3 24.7 345.4 265.3 88.4 7.1 0.0 6.7 11.5 7.4 880.6 0.0 1008.4 0.0 16.1 35.7 0.7 5.8 10.1 12.6 2.4 8.2 0.3 85.8 12.6 228.6 67.7 483.8 11.2 3.6 1664.3 0.0 7.5 615.7 12.1 0.0 187.7 1.6 855.4 0.0 7285.9 23.2 59.4 138.1 799.9 1053.3 21.6 1.4 56.5 155.1 33.4 55.4 6.7 1.2 249.0 CRYBA1 CRYB1 ENSG00000108255 "Crystallin beta A1" P05813 17 29246859-29254494 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Eye lens protein" Cataract "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 8 "brain: 2.1" "Group enriched" "Detected in some" 4 "Extravillous trophoblasts: 1.1;Syncytiotrophoblasts: 2.9" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "AF22: 3.2;BEWO: 4.1;SuSa: 1.0" "Group enriched" "Detected in some" 7 "hippocampal formation: 2.7;hypothalamus: 1.2;thalamus: 1.2" "Low region specificity" "Detected in all" HPA022016 Supported NA NA "Cluster 30: Non-specific - Translation" "Cluster 70: Brain - Nervous system development" "Cluster 28: BEWO - Transcription regulation" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" "HPA022016: AB_2732426" "unprognostic (2.89e-2)" "unprognostic (1.57e-1)" "unprognostic (8.75e-2)" "unprognostic (1.37e-1)" "unprognostic (9.62e-2)" "unprognostic (4.27e-3)" "unprognostic (2.08e-1)" "unprognostic (5.60e-2)" "unprognostic (2.52e-2)" "unprognostic (9.90e-2)" "unprognostic (5.85e-3)" "unprognostic (2.83e-1)" "unprognostic (2.09e-6)" "unprognostic (1.18e-1)" "unprognostic (1.86e-2)" "unprognostic (4.31e-2)" "unprognostic (6.84e-3)" 0.0 0.0 0.2 0.1 0.7 0.1 0.0 1.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.9 0.4 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 3.2 0.0 0.0 0.0 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.7 1.4 0.6 0.2 0.3 0.9 0.4 0.9 0.3 0.8 2.1 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.3 0.0 1.1 0.0 0.5 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 2.9 0.1 0.0 0.0 0.0 CRYBA2 ENSG00000163499 "Crystallin beta A2" P53672 2 218990189-218993422 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Eye lens protein" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 11.1;pancreas: 16.6;pituitary gland: 13.7" "Cell type enriched" "Detected in some" 34 "Enteroendocrine cells: 860.9" "Cancer enriched" "Detected in some" 15 "pancreatic cancer: 16.0" "Region enhanced" "Detected in many" "midbrain: 11.1" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 7 "BEWO: 69.6" "Region enhanced" "Detected in some" "pons and medulla: 4.3" "Low region specificity" "Detected in some" HPA062293 Supported NA NA "Cluster 22: Non-specific - Unknown function" "Cluster 28: BEWO - Transcription regulation" "Cluster 17: Intestinal endocrine cells - Hormone signaling" "HPA062293: AB_2732680" "unprognostic (5.29e-2)" "unprognostic (1.24e-1)" "unprognostic (2.15e-1)" "unprognostic (4.19e-1)" "unprognostic (6.19e-2)" "unprognostic (1.77e-1)" "unprognostic (2.72e-1)" "unprognostic (1.66e-2)" "unprognostic (3.75e-1)" "prognostic favorable (7.62e-4)" "unprognostic (2.91e-1)" "unprognostic (1.90e-1)" "unprognostic (2.19e-1)" 0.3 3.5 0.5 0.0 1.0 0.0 0.0 0.7 0.8 0.0 0.3 2.1 2.8 0.0 0.2 0.2 0.0 0.0 0.1 0.5 0.9 0.2 0.0 0.0 0.0 2.0 11.1 0.0 16.6 1.4 13.7 0.0 5.0 0.8 2.2 0.2 0.1 0.0 0.1 0.2 2.7 0.0 0.4 0.0 4.5 2.4 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.0 0.0 0.0 0.0 0.0 69.6 0.0 0.0 0.0 0.0 0.0 0.6 0.0 1.2 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 6.0 0.0 0.0 0.0 0.0 0.0 10.3 2.5 2.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 1.9 0.1 0.2 0.1 0.1 1.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 1.0 0.7 0.8 0.5 0.9 2.0 11.1 5.0 0.4 1.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.6 0.2 0.5 0.4 0.0 0.0 0.0 0.0 0.3 0.0 3.6 0.0 0.0 3.8 0.0 0.0 0.1 860.9 0.0 0.1 1.3 4.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 25.0 0.0 0.0 0.4 10.0 0.0 0.1 1.8 0.0 0.0 0.1 0.0 0.0 0.0 7.5 17.5 0.0 0.0 1.0 3.9 0.0 0.0 0.9 0.0 0.0 0.0 0.6 4.5 0.0 0.3 0.3 0.1 0.0 1.7 0.0 CRYBA4 ENSG00000196431 "Crystallin beta A4" P53673 22 26621963-26630669 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Eye lens protein" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "epididymis: 1.5;testis: 1.1" "Cell type enhanced" "Detected in some" "Early spermatids: 3.3;NK-cells: 1.0;Spermatogonia: 3.2" "Cancer enhanced" "Detected in some" "endometrial cancer: 2.0;testis cancer: 2.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "HEL: 7.3" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 4 "cerebral cortex: 4.3;hippocampal formation: 4.0" HPA071178 Supported NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 36: HEL - Hemostasis" "Cluster 23: Spermatids - Flagellum & Golgi organization" "HPA071178: AB_2686354" "unprognostic (6.69e-2)" "unprognostic (3.94e-3)" "unprognostic (5.61e-5)" "unprognostic (1.74e-2)" "unprognostic (5.57e-2)" "unprognostic (2.32e-2)" "unprognostic (2.71e-1)" "unprognostic (7.92e-2)" "unprognostic (3.50e-2)" "unprognostic (1.85e-1)" "unprognostic (9.05e-6)" "unprognostic (2.86e-1)" "unprognostic (1.20e-6)" "unprognostic (1.87e-2)" "unprognostic (7.23e-2)" "unprognostic (7.71e-2)" "unprognostic (3.70e-1)" 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.1 0.2 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 1.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.3 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.3 0.4 0.0 0.0 3.3 0.0 0.0 0.1 0.0 0.4 0.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.0 0.8 0.3 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.1 0.0 0.0 0.0 0.8 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.9 3.2 0.0 0.0 0.3 0.1 0.0 0.5 0.1 CRYBB1 ENSG00000100122 "Crystallin beta B1" P53674 22 26599278-26618027 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Eye lens protein" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "epididymis: 9.6" "Cell type enriched" "Detected in some" 21 "Hofbauer cells: 82.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 6 "intermediate monocyte: 10.3;non-classical monocyte: 7.5" "Lineage enriched" "Detected in many" 7 "monocytes: 10.3" "Group enriched" "Detected in some" 5 "Karpas-707: 43.3;RPMI-8226: 82.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in some" "HPA003448, CAB010058" Supported NA NA 89000 "Cluster 51: Monocytes - Innate immune response" "Cluster 68: Epididymis - Unknown function" "Cluster 25: RPMI-8226 - Immune response" "Cluster 4: Macrophages - Innate immune response" "CAB010058: AB_668166, HPA003448: AB_2732396" "unprognostic (1.31e-1)" "unprognostic (5.56e-3)" "unprognostic (1.39e-2)" "unprognostic (1.44e-2)" "unprognostic (2.29e-1)" "unprognostic (2.18e-1)" "unprognostic (7.89e-3)" "unprognostic (1.51e-1)" "unprognostic (9.51e-2)" "unprognostic (1.05e-1)" "unprognostic (1.10e-1)" "unprognostic (1.33e-1)" "unprognostic (3.88e-4)" "unprognostic (2.62e-2)" "unprognostic (1.23e-2)" "unprognostic (3.22e-1)" "unprognostic (1.76e-2)" 1.3 1.6 1.5 0.9 1.6 0.6 0.6 1.6 2.4 0.6 1.3 0.5 0.4 0.3 9.6 0.4 0.4 1.2 0.4 1.6 1.6 0.2 0.4 0.5 1.2 1.9 1.8 0.2 0.2 0.3 0.5 3.3 2.3 0.2 0.4 0.0 0.4 0.2 0.1 0.1 0.4 0.9 1.9 1.6 0.3 0.3 2.2 0.4 0.2 0.2 0.5 1.1 0.2 2.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.7 0.0 0.0 0.0 1.5 12.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 43.3 0.0 0.0 0.0 0.3 1.8 0.0 0.0 0.8 0.0 82.3 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.0 4.6 0.0 0.2 0.5 0.0 0.0 0.7 0.2 1.8 0.0 2.2 0.0 0.0 1.0 0.0 0.0 10.3 0.0 0.2 0.0 0.0 1.5 0.0 0.0 0.0 0.4 0.5 7.5 0.0 0.0 0.6 1.5 1.6 1.6 2.4 1.6 1.6 1.9 1.8 2.3 1.9 2.2 2.1 0.1 0.0 0.0 0.7 0.9 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.4 0.0 0.1 1.3 0.0 0.0 0.9 0.0 0.5 0.2 0.0 0.1 1.3 0.0 0.0 0.2 82.6 0.0 0.2 0.0 0.0 3.5 0.8 0.6 0.0 2.8 1.8 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.7 0.1 0.2 0.0 0.0 CRYBB2 "CCA2, CRYB2, CRYB2A" ENSG00000244752 "Crystallin beta B2" P43320 22 25212564-25231870 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Sensory transduction, Vision" "Eye lens protein" Cataract "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 4.5" "Cell type enhanced" "Detected in many" "Breast glandular cells: 10.6;Breast myoepithelial cells: 12.8;Distal tubular cells: 27.4;Melanocytes: 12.4" "Cancer enhanced" "Detected in some" "endometrial cancer: 1.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "HeLa: 2.1" "Region enhanced" "Detected in some" "hippocampal formation: 1.7" "Low region specificity" "Detected in many" HPA043749 Supported Approved Nucleoplasm NA NA "Cluster 65: Brain - Ion transport" "Cluster 20: HeLa - Mitochondria" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "HPA043749: AB_2678652" "unprognostic (1.28e-1)" "unprognostic (2.71e-2)" "unprognostic (4.09e-2)" "unprognostic (1.95e-1)" "unprognostic (5.06e-2)" "unprognostic (7.04e-2)" "unprognostic (8.57e-3)" "unprognostic (9.51e-3)" "unprognostic (8.55e-2)" "unprognostic (2.46e-2)" "unprognostic (4.13e-2)" "unprognostic (2.01e-1)" "unprognostic (1.73e-5)" "unprognostic (1.44e-2)" "unprognostic (1.60e-1)" "unprognostic (3.28e-1)" "unprognostic (9.89e-3)" 0.2 0.4 2.7 0.0 2.6 0.0 0.3 2.0 4.5 0.3 2.0 0.4 0.2 0.1 0.3 0.4 0.1 0.1 0.2 2.7 2.3 0.5 0.3 0.3 0.0 2.1 2.2 0.1 0.2 0.0 1.4 0.0 2.5 0.6 0.3 0.4 0.3 0.1 0.5 0.4 0.3 0.2 2.0 0.1 0.2 1.7 2.9 0.0 1.0 0.0 0.0 0.2 0.4 2.5 0.1 0.2 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.2 0.0 0.3 0.4 0.0 0.0 0.0 0.0 0.6 0.1 2.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.2 0.1 0.2 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.1 0.3 0.5 0.0 0.9 0.2 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.2 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.2 0.1 0.2 0.0 0.0 2.7 2.6 2.0 4.5 2.7 2.3 2.1 2.2 2.5 2.0 2.9 2.5 0.9 0.0 0.0 2.0 1.0 5.4 0.6 6.7 0.6 0.3 10.6 12.8 1.4 1.5 1.5 1.8 0.0 0.1 0.9 1.7 27.4 0.1 3.0 1.7 1.2 2.9 0.0 8.0 2.4 0.2 0.1 3.4 0.0 2.5 0.0 3.1 4.6 3.2 0.2 0.0 0.4 0.3 0.0 1.2 3.1 9.6 2.5 0.8 12.4 1.9 0.0 0.4 0.0 0.5 0.3 0.5 0.1 8.2 0.0 0.4 0.0 9.7 0.6 0.1 0.0 6.2 2.1 2.6 3.3 0.4 3.8 0.1 1.3 7.6 0.2 0.6 CRYBB3 CRYB3 ENSG00000100053 "Crystallin beta B3" P26998 22 25199858-25207359 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Eye lens protein" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in some" "Cell type enhanced" "Detected in some" "Distal enterocytes: 2.6;Distal tubular cells: 1.9;granulocytes: 4.5;Muller glia cells: 4.3;Proximal tubular cells: 10.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HaCaT: 1.4;HEK 293: 1.4;HeLa: 1.8;hTERT-HME1: 1.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in some" HPA055840 Supported Approved "Microtubules,Cytokinetic bridge,Mitotic spindle" Yes NA "Cluster 81: Kidney & Liver - Metabolism" "Cluster 20: HeLa - Mitochondria" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Microtubules "Cytokinetic bridge, Mitotic spindle" "HPA055840: AB_2682939" "unprognostic (1.36e-2)" "unprognostic (6.27e-4)" "unprognostic (6.30e-3)" "unprognostic (5.34e-2)" "unprognostic (8.76e-2)" "unprognostic (3.15e-2)" "unprognostic (6.45e-2)" "unprognostic (2.07e-2)" "unprognostic (4.15e-2)" "unprognostic (8.28e-2)" "unprognostic (2.40e-1)" "unprognostic (2.68e-2)" "unprognostic (1.03e-2)" "unprognostic (2.01e-1)" "unprognostic (1.76e-1)" "unprognostic (1.91e-1)" "unprognostic (1.20e-3)" 0.2 0.5 0.9 0.1 0.6 0.0 0.7 0.0 1.0 0.5 0.0 0.6 0.3 0.3 0.2 0.6 0.4 0.4 0.5 0.9 0.0 2.0 2.0 0.3 0.1 0.0 0.1 0.1 0.3 0.0 0.3 0.1 0.0 0.8 0.4 0.7 1.0 0.4 0.7 0.9 0.7 0.1 0.0 0.1 0.5 0.2 0.5 0.2 1.3 0.1 0.3 0.1 0.4 0.0 0.6 0.2 0.0 0.2 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.3 0.0 0.2 1.4 0.8 0.6 0.0 0.0 1.4 0.0 1.8 1.0 0.0 0.0 0.0 0.0 0.7 0.4 1.2 0.2 0.3 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.1 0.1 1.1 0.0 0.1 0.0 0.1 0.2 0.2 0.1 0.1 0.1 0.0 0.3 0.0 0.0 0.2 0.0 0.6 0.5 0.1 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.6 0.0 1.0 0.9 0.0 0.0 0.1 0.0 0.0 0.5 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.2 0.1 0.0 0.1 0.6 0.3 0.4 1.5 0.1 0.0 0.0 0.0 0.0 2.6 1.9 0.0 0.2 0.1 0.1 0.3 0.0 0.0 0.6 0.2 0.0 0.0 0.0 0.5 4.5 0.0 0.0 0.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.2 1.3 10.5 0.4 0.3 0.0 0.0 0.1 0.1 0.7 0.0 0.3 0.0 0.1 0.0 0.3 0.1 CRYGB CRYG2 ENSG00000182187 "Crystallin gamma B" P07316 2 208142573-208146158 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Eye lens protein" Cataract "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 5 "Early spermatids: 1.1" "Group enriched" "Detected in some" 6 "ovarian cancer: 1.1;testis cancer: 1.1" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 9 "hippocampal formation: 3.3;hypothalamus: 2.2;thalamus: 2.0" HPA043386 Supported Approved Vesicles,Cytosol NA NA "Cluster 29: Early spermatids - Spermatogenesis" "Vesicles, Cytosol" "HPA043386: " "unprognostic (6.73e-2)" "unprognostic (1.31e-1)" 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CRYGC CRYG3 ENSG00000163254 "Crystallin gamma C" P07315 2 208128137-208129828 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Eye lens protein" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 12 "testis: 1.7" "Group enriched" "Detected in some" 13 "Early spermatids: 1.9;Granulosa cells: 3.7;Late spermatids: 3.2;Spermatocytes: 2.1;Spermatogonia: 2.4" "Cancer enhanced" "Detected in some" "endometrial cancer: 0.8;ovarian cancer: 1.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 20 "hippocampal formation: 3.2;hypothalamus: 1.5;thalamus: 1.2" "Group enriched" "Detected in some" 14 "cerebral cortex: 1.2;hippocampal formation: 1.5" HPA043386 Supported Approved Vesicles,Cytosol NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 40: Granulosa cells - Unknown function" "Vesicles, Cytosol" "HPA043386: " "unprognostic (1.89e-1)" "unprognostic (2.89e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 3.7 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CRYGD CRYG4 ENSG00000118231 "Crystallin gamma D" P07320 2 208121607-208124524 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Sensory transduction, Vision" "Eye lens protein" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "ovary: 8.0" "Cell type enriched" "Detected in some" 4 "Granulosa cells: 140.2" "Cancer enhanced" "Detected in some" "testis cancer: 3.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 20 "HEL: 10.0" "Not detected" "Not detected" "HPA041269, HPA043386" Supported Approved Vesicles,Cytosol NA NA "Cluster 89: Fibroblasts - ECM organization" "Cluster 36: HEL - Hemostasis" "Cluster 40: Granulosa cells - Unknown function" "Vesicles, Cytosol" "HPA041269: AB_2732491, HPA043386: " "unprognostic (4.49e-2)" "unprognostic (2.64e-1)" "unprognostic (3.62e-1)" 0.0 0.0 0.5 0.0 0.4 1.3 0.0 0.2 0.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.5 0.6 0.0 0.0 0.0 0.0 0.5 0.7 8.0 0.0 0.0 0.4 0.0 0.6 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 1.4 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.5 0.0 0.0 0.0 0.0 10.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.4 0.2 0.8 0.5 0.6 0.5 0.7 0.6 0.3 0.8 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 12.2 0.0 0.0 0.1 0.0 4.6 0.3 0.0 0.1 0.9 0.0 0.0 0.0 140.2 0.0 0.0 0.2 0.0 0.4 0.0 0.0 0.0 0.0 4.2 0.0 0.4 0.0 0.0 0.0 34.5 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.0 1.3 0.0 0.0 0.9 0.1 1.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 CRYGS CRYG8 ENSG00000213139 "Crystallin gamma S" P22914 3 186538441-186546702 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Eye lens protein" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 10.5" "Cell type enhanced" "Detected in many" "Astrocytes: 5.2;Excitatory neurons: 5.4;Inhibitory neurons: 6.0;Microglial cells: 5.6;Oligodendrocyte precursor cells: 6.0;Oligodendrocytes: 7.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "HPA035103, HPA063539" Supported Uncertain Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 43: Cardiomyocytes - Nuclear processes" Cytosol "HPA035103: AB_10696367, HPA063539: " "unprognostic (5.52e-4)" "unprognostic (1.29e-3)" "unprognostic (1.44e-2)" "unprognostic (5.45e-2)" "unprognostic (4.90e-2)" "unprognostic (5.85e-2)" "unprognostic (4.79e-2)" "unprognostic (1.73e-2)" "unprognostic (4.76e-2)" "unprognostic (1.12e-1)" "unprognostic (5.84e-3)" "unprognostic (1.51e-1)" "prognostic unfavorable (3.72e-9)" "unprognostic (1.10e-1)" "unprognostic (9.53e-2)" "unprognostic (3.67e-1)" "prognostic favorable (2.73e-4)" 1.1 2.0 6.5 1.0 6.9 2.8 1.6 8.0 10.5 1.8 6.9 1.7 1.1 1.6 1.5 1.2 1.5 0.8 2.1 6.5 7.2 2.3 2.1 1.5 2.2 6.5 6.8 1.2 2.1 0.7 1.4 0.9 7.0 1.5 2.0 8.1 1.2 1.4 1.1 1.1 1.9 1.3 6.3 2.8 1.5 2.1 6.8 4.8 1.2 0.6 1.7 1.7 1.6 7.3 0.3 0.7 1.5 1.1 1.5 1.7 0.0 0.2 0.4 0.5 1.0 0.2 0.6 1.5 1.3 1.2 0.6 1.0 0.8 1.1 1.6 1.0 1.8 1.7 0.2 1.1 0.6 1.1 1.3 1.9 1.2 0.3 0.8 1.7 1.5 1.6 0.4 0.8 1.2 0.4 0.8 0.5 0.0 0.5 0.3 1.7 0.2 0.8 0.5 1.0 0.5 0.6 0.2 0.7 0.3 1.0 0.9 0.9 2.2 0.4 0.3 0.5 1.0 1.7 1.1 1.8 0.7 0.5 0.6 0.0 0.0 0.0 0.2 0.0 0.4 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 6.5 6.9 8.0 10.5 6.5 7.2 6.5 6.8 7.0 6.3 6.8 7.3 1.2 0.0 1.7 5.2 0.7 0.3 0.3 0.7 0.6 1.1 0.9 1.5 3.0 1.5 0.9 0.0 2.1 0.2 0.6 0.5 0.0 0.6 0.2 0.3 0.6 1.0 0.0 3.2 5.4 0.2 0.2 0.9 2.6 0.5 1.3 0.9 2.5 1.3 0.4 1.7 6.0 0.8 2.0 0.3 1.2 1.3 0.3 1.1 0.0 5.6 0.1 0.5 1.0 6.0 7.6 0.2 0.4 0.7 0.1 0.3 0.8 0.2 0.5 3.2 0.0 0.8 0.8 2.4 0.9 0.4 0.1 0.3 0.8 0.9 1.2 0.2 CRYM DFNA40 ENSG00000103316 "Crystallin mu" Q14894 16 21238874-21303083 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 78.7;heart muscle: 175.3" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 126.0;Ionocytes: 114.0;Muller glia cells: 640.7;Proximal tubular cells: 190.1" "Cancer enhanced" "Detected in many" "prostate cancer: 14.6" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 21 "plasmacytoid DC: 82.0" "Lineage enriched" "Detected in many" 21 "dendritic cells: 82.0" "Cell line enriched" "Detected in some" 4 "RPTEC TERT1: 100.3" "Group enriched" "Detected in all" 11 "amygdala: 124.0;basal ganglia: 275.1;cerebral cortex: 124.7;hippocampal formation: 324.3;white matter: 128.4" "Low region specificity" "Detected in all" "HPA019086, HPA030619" Enhanced Supported Cytosol NA NA 150000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 5: Muller glia cells - Visual perception" Cytosol "HPA019086: AB_1847260, HPA030619: AB_2673551" "unprognostic (1.32e-1)" "unprognostic (2.93e-3)" "unprognostic (8.96e-2)" "unprognostic (1.44e-1)" "unprognostic (2.13e-1)" "unprognostic (4.62e-2)" "unprognostic (2.88e-1)" "unprognostic (5.75e-3)" "unprognostic (2.81e-1)" "unprognostic (7.37e-2)" "unprognostic (2.05e-2)" "unprognostic (5.95e-2)" "unprognostic (2.11e-3)" "unprognostic (7.79e-3)" "unprognostic (2.49e-2)" "unprognostic (1.87e-3)" "unprognostic (1.31e-1)" 1.9 0.8 37.4 0.9 78.7 1.0 2.7 40.6 62.2 3.7 13.6 6.9 1.6 1.0 0.2 7.6 1.1 7.0 175.3 54.0 31.6 64.4 14.2 8.5 1.1 13.9 19.8 0.3 1.8 8.9 55.6 0.4 15.6 35.4 8.4 54.7 20.6 0.2 13.4 4.1 2.6 0.3 14.1 0.3 1.3 5.1 20.5 0.3 0.4 0.9 3.8 21.8 3.6 31.3 0.2 4.0 0.0 0.0 0.2 0.4 0.7 0.0 2.1 0.1 0.2 0.2 0.2 0.3 1.0 0.0 1.8 0.6 5.4 0.0 0.0 0.0 0.8 23.2 0.1 2.3 0.0 0.1 2.2 0.8 0.0 0.8 1.0 0.0 0.0 0.5 0.0 0.4 0.7 0.3 0.0 0.9 9.7 1.6 0.1 0.1 0.0 0.5 100.3 0.1 3.7 5.2 0.2 0.1 2.6 4.8 0.1 0.0 0.0 0.5 0.7 6.8 0.0 0.2 0.0 0.5 16.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 2.2 0.0 0.0 0.1 3.9 0.0 0.0 0.3 0.0 0.0 82.0 0.0 1.2 37.4 78.7 40.6 62.2 54.0 31.6 13.9 19.8 15.6 14.1 20.5 31.3 0.3 0.0 20.1 5.2 4.1 2.3 25.4 16.3 0.0 6.3 0.4 11.7 126.0 2.8 56.1 14.7 4.2 0.0 11.4 7.1 17.6 0.1 19.7 3.2 1.5 3.0 13.1 4.8 43.8 0.0 0.0 7.1 6.1 7.7 1.3 1.3 0.4 8.3 0.1 1.7 5.9 20.6 114.0 1.6 0.7 12.4 0.0 1.5 33.8 10.3 0.7 640.7 0.0 7.1 6.6 0.4 2.8 0.0 0.3 19.0 7.5 190.1 19.9 26.2 0.0 0.2 4.3 6.7 7.3 0.2 1.3 0.1 1.1 0.1 8.2 68.0 CSF1R "C-FMS, CD115, CSFR, FMS" ENSG00000182578 "Colony stimulating factor 1 receptor" P07333 5 150053291-150113372 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Immunity, Inflammatory response, Innate immunity" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Neurodegeneration, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 113.3;placenta: 103.3" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 103.2;Hofbauer cells: 340.4;Kupffer cells: 291.2;Langerhans cells: 73.4;Macrophages: 196.3;Microglial cells: 134.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "intermediate monocyte: 444.6;non-classical monocyte: 646.9" "Lineage enriched" "Detected in many" 5 "monocytes: 646.9" "Group enriched" "Detected in some" 4 "BEWO: 123.0;SK-BR-3: 47.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008970, HPA012323" Uncertain Supported "Vesicles,Plasma membrane" "Intracellular and membrane" NA NA 1600000000 "Cluster 51: Monocytes - Innate immune response" "Cluster 64: Macrophages - Immune response" "Cluster 28: BEWO - Transcription regulation" "Cluster 4: Macrophages - Innate immune response" "Vesicles, Plasma membrane" "CAB008970: , HPA012323: AB_1848977" "unprognostic (3.82e-2)" "unprognostic (1.31e-1)" "unprognostic (1.86e-3)" "unprognostic (9.83e-2)" "unprognostic (1.20e-1)" "unprognostic (7.33e-2)" "unprognostic (1.03e-1)" "unprognostic (1.45e-1)" "unprognostic (9.37e-2)" "unprognostic (1.11e-2)" "unprognostic (2.49e-1)" "unprognostic (1.65e-1)" "prognostic unfavorable (1.08e-4)" "unprognostic (3.67e-2)" "prognostic unfavorable (4.92e-4)" "unprognostic (1.72e-2)" "unprognostic (4.61e-2)" 51.3 31.0 19.6 75.1 17.1 5.6 19.3 20.2 21.4 21.6 19.3 21.9 24.3 12.1 5.8 21.0 17.2 40.6 16.6 19.8 33.8 7.1 27.5 36.6 54.4 41.4 35.5 12.7 9.9 11.8 5.7 103.3 40.1 9.1 21.5 1.5 10.1 20.8 3.2 13.4 37.3 41.9 36.6 113.3 21.0 7.0 40.6 14.3 6.0 11.8 21.7 42.6 3.8 67.6 4.5 0.2 0.0 0.0 1.9 0.4 123.0 0.2 0.2 0.0 0.0 3.8 0.0 5.9 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.1 0.1 0.1 0.2 1.1 3.0 0.0 6.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 6.1 0.1 0.0 0.0 0.0 1.9 0.6 0.0 0.0 0.2 0.2 0.0 47.8 0.0 1.9 0.0 20.7 0.0 0.8 0.2 0.1 3.3 0.0 0.3 0.1 6.6 2.6 0.0 3.0 138.4 4.0 0.6 444.6 0.6 0.3 0.2 0.4 139.0 0.2 0.3 0.2 21.6 0.2 646.9 11.1 0.5 132.7 19.6 17.1 20.2 21.4 19.8 33.8 41.4 35.5 40.1 36.6 40.6 67.6 2.0 0.0 3.8 0.0 4.3 2.8 0.0 0.0 1.2 0.0 0.5 2.3 3.1 4.3 0.0 0.0 0.0 6.2 2.8 0.0 0.0 0.0 4.8 0.0 0.1 10.5 0.0 2.5 0.4 0.0 103.2 2.2 1.5 0.2 2.5 8.3 2.9 1.5 340.4 0.0 0.5 0.3 0.0 291.2 73.4 5.4 1.8 196.3 3.6 134.9 39.4 0.0 1.0 1.5 0.3 0.1 1.7 0.0 1.0 0.0 0.0 0.1 0.7 0.5 13.1 1.2 2.0 2.2 0.2 0.4 1.3 26.4 1.3 2.2 0.2 0.0 CSNK1D "CKID, CKIdelta, HCKID" ENSG00000141551 "Casein kinase 1 delta" P48730 17 82239023-82273731 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Early spermatids: 312.5;Late spermatids: 775.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB015410 Approved Approved "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 72: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoli fibrillar center" Nucleoplasm "CAB015410: AB_831049" "unprognostic (1.07e-2)" "unprognostic (1.27e-1)" "unprognostic (2.31e-1)" "prognostic unfavorable (7.04e-4)" "unprognostic (2.38e-2)" "unprognostic (3.43e-2)" "prognostic unfavorable (2.38e-6)" "unprognostic (8.05e-2)" "unprognostic (1.09e-1)" "unprognostic (5.00e-2)" "prognostic favorable (9.62e-5)" "unprognostic (2.23e-3)" "prognostic unfavorable (8.34e-4)" "unprognostic (3.54e-1)" "unprognostic (2.52e-1)" "unprognostic (5.52e-3)" "unprognostic (4.74e-2)" 46.7 57.0 36.9 28.9 36.9 25.9 42.3 34.4 37.9 45.3 30.3 57.1 35.1 56.6 26.7 50.8 45.3 24.8 42.4 39.0 40.2 45.5 40.9 45.3 30.8 37.2 37.6 43.1 47.5 43.1 54.2 30.2 36.3 51.8 20.0 15.1 48.6 36.8 88.9 36.4 50.9 29.0 36.3 56.3 49.3 60.7 42.6 34.0 44.7 38.7 22.8 49.0 37.0 32.9 60.3 70.9 39.5 54.7 50.8 53.9 77.7 85.1 54.4 61.0 56.8 58.6 49.4 55.0 66.3 62.5 64.8 57.1 37.4 88.3 48.9 47.0 90.5 68.5 53.4 63.7 146.9 56.9 50.4 81.9 61.5 41.6 61.3 76.0 90.0 39.5 78.5 28.4 58.5 70.6 73.7 59.3 42.2 71.3 108.6 62.6 48.7 49.7 64.8 93.4 48.5 87.4 100.4 85.5 97.7 54.3 61.5 73.0 95.6 86.9 77.3 76.2 67.0 61.0 32.1 58.4 69.5 48.1 64.7 8.8 20.8 27.4 12.3 21.3 11.8 11.1 9.6 12.1 20.1 9.0 8.1 8.7 50.4 15.3 20.3 9.6 9.2 15.4 36.9 36.9 34.4 37.9 39.0 40.2 37.2 37.6 36.3 36.3 42.6 32.9 65.8 48.1 54.3 36.6 81.1 56.6 116.0 58.3 52.9 46.5 59.8 51.2 19.7 31.5 65.7 42.3 27.1 61.8 101.0 105.2 33.2 71.6 312.5 69.6 54.0 54.2 46.2 32.4 24.4 69.6 95.2 42.8 87.1 93.2 60.1 45.3 42.5 33.6 65.3 95.9 21.2 62.8 67.1 51.5 83.8 775.6 30.1 75.7 28.4 24.4 65.8 28.7 79.3 24.6 21.2 87.7 83.2 40.3 80.9 90.8 94.3 43.8 66.6 54.4 39.5 78.6 57.5 55.1 29.6 44.2 48.3 126.6 87.6 46.7 56.7 118.6 CST3 ENSG00000101439 "Cystatin C" P01034 20 23626706-23638473 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Protease inhibitor, Thiol protease inhibitor" "Age-related macular degeneration, Amyloidosis, Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 4217.6" "Cell type enriched" "Detected in all" 4 "Langerhans cells: 18746.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 7 "classical monocyte: 4967.5;intermediate monocyte: 6424.5;myeloid DC: 7959.0;non-classical monocyte: 4297.7;plasmacytoid DC: 4427.4" "Group enriched" "Detected in all" 9 "dendritic cells: 7959.0;monocytes: 6424.5" "Cell line enhanced" "Detected in many" "ASC diff: 1733.4;ASC TERT1: 1179.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000118, HPA013143" Enhanced Supported "Golgi apparatus,Vesicles" "Secreted to blood" NA NA 1040000000 2800000000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 41: Macrophages - Immune response" "Golgi apparatus, Vesicles" "CAB000118: , HPA013143: AB_1847417" "unprognostic (3.89e-2)" "unprognostic (1.63e-1)" "unprognostic (1.45e-1)" "prognostic favorable (1.83e-4)" "unprognostic (8.53e-2)" "unprognostic (4.06e-2)" "unprognostic (2.10e-2)" "unprognostic (2.18e-2)" "unprognostic (3.46e-2)" "unprognostic (3.72e-1)" "unprognostic (2.29e-3)" "unprognostic (3.51e-2)" "unprognostic (1.85e-1)" "unprognostic (1.16e-1)" "unprognostic (2.97e-1)" "unprognostic (5.01e-2)" "prognostic favorable (8.77e-4)" 1046.2 707.6 3041.2 262.3 3117.9 170.8 900.3 2823.3 4217.6 587.8 3094.8 788.7 389.6 708.3 875.9 557.1 802.7 583.0 1275.3 2976.3 2707.6 517.4 833.6 595.8 463.5 3258.4 3096.2 575.8 944.1 320.0 670.1 165.9 2939.3 773.9 416.9 46.9 2008.0 441.5 749.0 497.1 800.3 367.6 3028.1 723.7 979.9 761.3 3302.7 418.9 658.8 517.4 208.1 703.0 618.4 2883.1 155.2 328.2 75.4 175.8 1733.4 1179.8 145.3 261.4 350.7 170.3 137.7 625.1 219.7 0.8 241.0 345.2 221.3 496.2 69.6 499.9 51.9 0.9 253.5 157.6 61.1 1082.9 621.2 7.5 251.0 919.0 415.9 226.6 241.5 352.5 268.5 18.5 147.6 4.0 239.5 234.4 1.5 162.2 103.5 461.9 752.2 5.7 96.4 215.2 708.0 328.3 84.7 98.2 191.1 54.6 343.3 107.7 156.5 548.2 702.0 163.4 119.0 231.6 97.7 157.1 6.2 1.8 138.0 339.5 184.0 48.1 4967.5 33.2 66.9 6424.5 25.5 23.1 18.3 45.8 7959.0 13.6 16.9 31.1 809.3 191.4 4297.7 4427.4 13.6 4250.8 3041.2 3117.9 2823.3 4217.6 2976.3 2707.6 3258.4 3096.2 2939.3 3028.1 3302.7 2883.1 662.4 115.4 168.8 849.5 93.8 942.9 571.1 568.2 213.9 152.4 660.2 512.1 240.7 1361.2 514.5 641.9 29.2 476.8 603.3 1889.9 414.8 489.9 46.2 441.1 795.0 728.2 882.1 252.1 4.5 783.6 308.7 3026.2 981.7 631.0 359.9 687.0 491.9 2563.0 1816.7 48.8 11.2 1360.6 691.7 4301.1 18746.6 184.3 2132.6 4542.6 1563.5 87.1 2025.6 248.7 99.9 263.9 6.0 1458.5 2342.1 1790.4 67.9 786.0 4301.1 1098.6 364.4 36.3 2195.7 1417.0 846.2 125.5 400.6 461.5 822.0 469.0 117.4 208.1 1039.4 1079.7 CSTB "CST6, EPM1, PME, STFB" ENSG00000160213 "Cystatin B" P04080 21 43772511-43776330 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Protease inhibitor, Thiol protease inhibitor" "Cancer-related genes, Disease variant, Epilepsy, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 8 "esophagus: 11304.7" "Cell type enhanced" "Detected in all" "Basal respiratory cells: 5910.7;Club cells: 4352.8;Hofbauer cells: 2827.7;Squamous epithelial cells: 4910.2;Urothelial cells: 3198.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RT4: 2798.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017380, CAB047320, HPA058557" Enhanced Supported Nucleoli,Cytosol NA NA 8700000 "Cluster 51: Monocytes - Innate immune response" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Cytosol Nucleoli "CAB047320: , HPA017380: AB_1847414, HPA058557: AB_2683755" "unprognostic (1.69e-1)" "unprognostic (3.35e-1)" "unprognostic (2.09e-1)" "unprognostic (3.05e-2)" "unprognostic (3.05e-2)" "unprognostic (5.92e-2)" "prognostic unfavorable (6.66e-5)" "unprognostic (1.90e-1)" "unprognostic (1.32e-1)" "unprognostic (2.14e-1)" "unprognostic (1.27e-2)" "unprognostic (1.79e-1)" "prognostic unfavorable (2.10e-4)" "unprognostic (3.63e-1)" "unprognostic (4.88e-1)" "unprognostic (4.24e-2)" "unprognostic (1.24e-1)" 224.3 165.6 254.1 141.6 253.6 73.8 161.9 255.4 314.6 585.8 275.2 243.8 122.9 90.1 175.0 11304.7 154.1 150.7 192.2 252.8 263.0 144.7 189.4 290.1 176.4 258.4 257.8 136.1 116.2 154.4 70.1 132.1 259.6 137.3 194.7 78.9 738.3 138.6 100.1 256.9 135.6 110.4 257.5 125.8 249.9 71.7 262.8 268.2 147.9 197.4 1484.9 611.8 1001.9 262.9 1573.6 495.5 146.3 188.1 874.5 742.6 379.6 310.1 431.0 230.7 230.6 401.6 868.6 123.0 245.8 570.1 1814.0 260.5 384.4 405.7 153.5 529.0 388.4 332.4 385.3 473.8 753.0 85.5 267.1 754.5 439.6 621.2 314.7 389.3 331.2 111.8 276.9 681.1 359.7 431.4 100.1 267.6 336.0 1052.6 791.5 169.7 80.5 1472.0 669.1 2798.2 141.8 121.6 420.2 229.2 928.8 75.7 210.4 214.0 426.3 347.7 162.7 305.5 211.8 148.5 347.4 251.1 1432.5 430.2 242.3 390.1 505.5 313.1 242.9 840.3 224.5 198.5 315.4 255.4 766.1 172.7 221.0 217.6 445.6 152.4 1322.9 93.4 406.9 475.2 254.1 253.6 255.4 314.6 252.8 263.0 258.4 257.8 259.6 257.5 262.8 262.9 210.1 176.3 298.4 43.4 140.5 385.3 460.6 5910.7 191.2 69.8 317.8 345.1 105.7 268.8 4352.8 415.6 35.5 310.4 126.5 803.9 538.1 588.4 10.4 388.8 205.1 307.8 239.3 61.4 17.0 488.2 1199.4 238.6 297.7 458.8 228.2 131.5 250.6 464.5 2827.7 67.3 18.4 308.6 1462.8 483.4 1256.2 40.8 381.1 806.9 471.4 24.4 915.9 160.6 255.4 11.1 32.4 810.9 735.6 330.2 167.7 674.3 524.9 469.9 1997.3 72.9 118.3 86.5 320.0 33.7 111.7 4910.2 596.0 402.5 202.8 170.9 367.2 3198.3 CTC1 "AAF132, C17orf68, FLJ22170" ENSG00000178971 "CST telomere replication complex component 1" Q2NKJ3 17 8224815-8248056 "Disease related genes, Human disease related genes, Predicted intracellular proteins" DNA-binding "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 37.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA052436 Supported Nucleoplasm,Cytosol NA NA "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 51: Non-specific - Unknown function" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 59: Non-specific - Transcription" Nucleoplasm Cytosol "HPA052436: " "unprognostic (6.47e-2)" "unprognostic (1.06e-2)" "unprognostic (6.16e-3)" "unprognostic (2.81e-3)" "unprognostic (1.33e-1)" "unprognostic (2.20e-3)" "unprognostic (3.96e-1)" "unprognostic (2.07e-2)" "unprognostic (3.00e-1)" "unprognostic (5.66e-2)" "prognostic favorable (6.49e-5)" "unprognostic (2.89e-3)" "unprognostic (3.24e-1)" "unprognostic (5.76e-2)" "unprognostic (1.47e-1)" "unprognostic (1.77e-2)" "unprognostic (1.66e-2)" 13.8 11.8 13.4 14.7 14.1 18.5 15.9 19.7 18.8 17.6 13.2 16.9 8.0 13.5 10.7 11.1 17.2 6.9 11.7 13.4 13.4 16.6 18.3 18.5 24.1 13.2 13.3 19.9 18.2 10.4 21.4 6.1 13.3 16.6 10.4 22.2 12.4 9.0 7.0 14.1 25.0 9.3 12.2 37.2 15.8 10.8 13.7 31.2 18.0 5.7 21.4 14.8 13.4 14.6 3.0 6.6 5.9 5.5 18.1 4.3 7.2 3.4 3.8 4.8 3.2 5.0 8.8 10.8 3.4 5.9 3.5 10.0 7.0 5.2 3.0 8.0 6.8 5.3 7.2 6.5 3.0 1.7 16.1 4.4 5.5 6.3 8.6 9.5 8.7 15.4 5.1 3.6 3.4 3.9 18.6 7.3 4.8 9.7 1.6 8.7 2.3 6.9 12.4 7.1 5.2 5.9 6.7 8.6 6.0 10.9 5.3 5.0 11.6 1.5 3.6 3.6 4.0 7.4 4.7 7.1 2.9 6.5 4.5 2.0 0.7 1.2 2.0 0.9 2.0 2.2 2.0 1.9 0.7 2.6 2.8 2.5 2.5 1.3 1.2 2.2 1.8 1.0 13.4 14.1 19.7 18.8 13.4 13.4 13.2 13.3 13.3 12.2 13.7 14.6 6.3 0.0 11.1 8.5 16.7 1.9 3.0 1.0 3.4 7.7 6.2 4.1 3.4 7.2 3.0 5.5 37.5 6.4 12.0 4.6 1.9 3.6 3.7 3.6 2.6 6.4 6.7 1.7 10.2 3.8 3.9 3.8 5.6 5.5 6.3 4.0 5.7 8.1 3.9 1.7 10.3 5.8 2.0 8.2 1.0 6.2 4.4 3.5 0.0 3.7 5.6 2.5 6.2 9.0 6.6 4.4 9.4 2.2 9.6 4.1 4.5 2.2 3.0 17.3 0.0 3.1 4.1 4.7 4.2 3.9 2.0 11.1 10.3 2.1 3.5 3.4 CTLA4 "CD, CD152, CELIAC3, CTLA-4, GSE, IDDM12" ENSG00000163599 "Cytotoxic T-lymphocyte associated protein 4" P16410 2 203867771-203873965 "CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Adaptive immunity, Immunity" "Diabetes mellitus, Disease variant, FDA approved drug targets, Systemic lupus erythematosus" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "lymphoid tissue: 37.4" "Cell type enriched" "Detected in some" 8 "T-cells: 41.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Immune cell enriched" "Detected in some" 7 "T-reg: 44.5" "Lineage enriched" "Detected in single" 445 "T-cells: 44.5" "Cell line enhanced" "Detected in some" "Karpas-707: 1.5;SK-MEL-30: 3.0;U-266/70: 4.3;U-266/84: 13.5" "Not detected" "Not detected" "Not detected" "Not detected" "Intracellular and membrane" NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 16: Immune cells - Immune response" "Cluster 16: U-266 - Nucleosome" "Cluster 24: Non-specific - Transcription regulation" "unprognostic (1.92e-2)" "unprognostic (9.13e-3)" "unprognostic (1.47e-3)" "unprognostic (9.89e-6)" "unprognostic (1.86e-1)" "prognostic favorable (4.48e-5)" "unprognostic (1.02e-1)" "unprognostic (1.75e-2)" "unprognostic (1.84e-3)" "unprognostic (2.65e-3)" "unprognostic (2.77e-1)" "unprognostic (3.76e-1)" "unprognostic (9.86e-10)" "unprognostic (4.13e-2)" "unprognostic (7.45e-2)" "unprognostic (4.94e-2)" "unprognostic (1.19e-2)" 1.1 0.2 0.4 18.5 0.4 6.1 1.0 0.4 0.7 0.6 0.5 1.3 0.3 0.3 0.0 1.6 0.6 5.2 0.5 0.5 0.5 0.6 0.7 2.9 37.4 1.3 0.7 0.1 0.4 0.5 0.3 0.3 1.1 1.5 3.2 0.0 0.5 1.0 0.1 0.7 6.2 0.8 0.6 3.9 2.9 1.1 0.5 10.1 1.1 0.2 17.0 5.8 0.8 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.1 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.2 0.0 0.2 0.0 0.1 0.0 4.3 13.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.5 0.0 6.2 0.8 0.0 0.0 1.4 0.3 0.0 0.0 0.0 0.0 44.5 0.6 0.4 0.4 0.4 0.7 0.5 0.5 1.3 0.7 1.1 0.6 0.5 0.5 0.4 0.0 3.2 0.0 1.6 0.5 0.0 0.0 0.0 0.0 0.3 0.3 0.2 0.0 0.0 0.0 0.0 0.3 0.8 0.0 0.0 0.0 0.4 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.2 4.1 0.0 1.3 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.1 0.2 0.0 3.3 0.0 2.8 0.2 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.3 1.0 0.2 0.9 0.1 41.9 0.0 0.0 0.1 CTNNA1 CAP102 ENSG00000044115 "Catenin alpha 1" P35221 5 138610967-138935034 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cell adhesion" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB021089, HPA046119, HPA063535" Approved Enhanced "Plasma membrane,Cell Junctions" NA NA 57000 "Cluster 51: Monocytes - Innate immune response" "Cluster 46: Fibroblasts - ECM organization" "Cluster 39: CACO-2 - Unknown function" "Cluster 16: Pancreatic endocrine cells - Mixed function" "Plasma membrane, Cell Junctions" "CAB021089: AB_10123543, HPA046119: AB_2679547, HPA063535: AB_2685033" "unprognostic (2.25e-3)" "unprognostic (3.32e-2)" "unprognostic (2.82e-3)" "unprognostic (1.80e-1)" "unprognostic (8.40e-2)" "unprognostic (2.35e-1)" "unprognostic (1.66e-3)" "unprognostic (4.83e-2)" "unprognostic (2.28e-1)" "unprognostic (2.48e-1)" "prognostic unfavorable (8.02e-4)" "unprognostic (6.18e-2)" "prognostic favorable (7.34e-7)" "unprognostic (1.54e-1)" "unprognostic (2.31e-1)" "unprognostic (7.62e-2)" "unprognostic (1.04e-1)" 144.4 137.1 88.3 65.9 110.4 33.1 126.4 102.9 100.6 110.9 103.2 155.8 115.5 99.2 115.7 208.9 113.4 95.6 190.7 83.7 91.3 151.8 82.4 134.4 35.6 106.8 99.4 101.5 83.8 120.4 54.3 124.6 105.2 96.3 122.9 54.0 127.7 104.0 87.1 140.6 115.2 115.5 95.9 66.0 125.3 35.0 100.2 33.0 122.9 62.0 69.3 126.8 126.3 139.0 225.3 161.1 237.9 353.6 202.2 220.8 362.0 222.0 277.9 208.1 261.1 337.9 297.4 0.8 182.9 334.3 228.0 167.7 165.9 366.0 240.0 129.6 144.0 94.3 245.7 206.5 243.6 1.7 88.2 140.5 286.0 249.1 269.6 230.6 397.7 66.0 52.9 94.3 227.2 199.4 2.3 28.9 96.2 237.4 3.6 88.8 138.0 135.7 441.9 295.5 94.9 124.8 409.7 568.2 344.3 503.4 201.5 64.4 341.1 217.1 117.4 136.5 156.5 33.8 69.9 13.5 207.0 40.3 286.7 5.1 37.8 3.4 5.8 46.4 3.8 7.9 4.1 4.3 32.3 6.6 0.3 2.1 20.9 0.6 46.8 7.9 11.1 17.8 88.3 110.4 102.9 100.6 83.7 91.3 106.8 99.4 105.2 95.9 100.2 139.0 137.3 259.6 161.0 57.1 19.4 78.5 119.5 134.4 82.0 7.3 74.6 52.3 230.8 87.2 201.8 121.4 20.9 124.8 21.1 320.7 68.4 184.9 17.2 158.0 67.9 141.1 51.0 41.7 37.6 175.5 137.8 97.1 167.1 206.9 40.5 83.3 92.4 66.6 92.8 3.3 31.5 139.0 87.5 80.5 80.9 23.6 77.9 77.9 78.2 104.0 158.5 46.2 6.2 66.4 159.7 328.7 201.4 84.7 24.8 128.7 165.6 140.1 210.1 24.5 98.6 74.9 109.1 18.1 21.0 111.3 77.3 189.9 20.4 44.4 130.6 181.4 CUX2 "CDP2, CUTL2, KIAA0293" ENSG00000111249 "Cut like homeobox 2" O14529 12 111034165-111350554 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors" "Transcription, Transcription regulation" DNA-binding "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 20.6;choroid plexus: 25.7;liver: 20.4;prostate: 11.4" "Cell type enhanced" "Detected in some" "dendritic cells: 28.1;Excitatory neurons: 175.4;Hepatocytes: 50.9;Horizontal cells: 26.9;Inhibitory neurons: 72.5" "Group enriched" "Detected in some" 4 "liver cancer: 5.2;prostate cancer: 11.2" "Region enhanced" "Detected in many" "cerebral cortex: 20.6" "Immune cell enriched" "Detected in single" 70 "plasmacytoid DC: 6.9" "Lineage enriched" "Detected in single" 70 "dendritic cells: 6.9" "Cell line enhanced" "Detected in some" "HBEC3-KT: 6.6;HDLM-2: 2.9;hTERT-HME1: 3.5;SCLC-21H: 6.5;SH-SY5Y: 14.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "unprognostic (3.87e-2)" "unprognostic (6.98e-3)" "unprognostic (1.17e-1)" "unprognostic (1.17e-1)" "unprognostic (1.30e-1)" "unprognostic (2.78e-2)" "unprognostic (1.22e-2)" "unprognostic (9.44e-2)" "unprognostic (2.33e-1)" "unprognostic (3.30e-2)" "unprognostic (7.83e-5)" "unprognostic (2.67e-1)" "unprognostic (3.54e-3)" "unprognostic (4.31e-2)" "unprognostic (9.03e-2)" "unprognostic (4.64e-2)" "unprognostic (1.90e-2)" 0.0 0.0 2.3 0.2 1.4 0.2 1.8 0.0 20.6 0.8 25.7 0.3 0.1 0.1 0.3 0.1 0.0 0.0 0.0 3.5 0.0 0.2 20.4 0.0 0.5 0.0 1.5 0.0 0.1 0.0 2.1 0.0 0.0 11.4 0.0 2.3 0.0 2.9 0.1 0.2 0.2 0.0 0.0 0.2 1.5 0.5 5.2 0.2 4.2 0.1 0.4 0.1 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 6.6 0.0 2.9 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 2.1 0.0 0.0 0.2 0.0 0.1 0.0 0.0 6.5 14.0 0.0 0.0 0.0 0.4 0.3 0.2 0.0 0.0 0.8 0.0 0.0 0.3 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.9 0.0 0.0 2.3 1.4 0.0 20.6 3.5 0.0 0.0 1.5 0.0 0.0 5.2 0.0 0.0 0.0 0.0 7.2 0.5 0.0 3.5 0.7 0.0 6.4 2.6 3.0 1.0 2.8 0.1 0.0 0.0 0.0 28.1 0.1 0.0 0.0 1.2 3.7 0.1 0.1 0.0 2.7 175.4 0.0 0.0 0.1 0.0 0.8 0.0 0.0 0.4 50.9 0.7 26.9 72.5 0.0 0.0 0.6 0.0 0.6 0.0 0.5 0.0 1.9 0.0 0.1 0.0 20.1 1.8 0.0 0.0 0.0 0.0 6.5 0.0 0.0 0.1 0.9 0.0 0.3 0.1 0.8 0.8 0.0 0.0 0.0 0.1 0.0 0.0 0.6 CWF19L1 "FLJ10998, hDrn1" ENSG00000095485 "CWF19 like cell cycle control factor 1" Q69YN2 10 100232298-100267680 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Neurodegeneration "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" "HPA036889, HPA036890" Uncertain Approved "Nucleoplasm,Golgi apparatus" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 23: Spermatids - Flagellum & Golgi organization" "Nucleoplasm, Golgi apparatus" "HPA036889: AB_10670928, HPA036890: AB_10696789" "unprognostic (2.76e-2)" "unprognostic (1.10e-2)" "unprognostic (1.16e-1)" "unprognostic (1.39e-1)" "unprognostic (3.66e-2)" "unprognostic (1.74e-1)" "prognostic unfavorable (6.90e-4)" "unprognostic (3.04e-1)" "unprognostic (9.17e-3)" "unprognostic (3.61e-1)" "unprognostic (2.70e-2)" "unprognostic (6.50e-3)" "unprognostic (5.61e-3)" "unprognostic (6.16e-2)" "unprognostic (2.60e-2)" "unprognostic (1.18e-1)" "unprognostic (1.10e-1)" 8.1 6.9 5.9 11.4 6.3 18.8 11.6 7.5 7.6 7.9 5.1 7.2 6.8 8.2 5.7 6.9 8.7 6.7 7.4 5.9 6.5 7.8 8.2 7.5 16.4 6.0 5.8 10.3 8.0 9.0 6.1 9.0 6.3 6.8 8.6 10.3 8.6 6.5 10.1 11.2 8.1 9.3 6.3 11.8 6.6 14.3 6.0 14.8 8.1 10.2 16.9 8.5 6.6 8.4 29.1 18.8 18.7 29.2 9.1 10.8 20.7 17.2 23.8 37.5 30.6 21.5 22.6 30.5 19.4 16.6 16.3 27.9 42.2 24.9 39.6 19.4 20.8 17.5 15.8 20.6 15.8 44.7 19.6 15.2 10.4 28.0 26.2 14.2 26.6 30.8 20.7 26.8 21.9 18.3 36.2 32.4 14.7 15.0 23.2 12.6 29.2 21.2 15.0 16.5 9.4 16.8 20.6 10.3 26.0 12.6 37.3 19.1 18.6 15.8 21.5 18.3 32.8 23.9 29.6 17.9 20.1 39.1 11.4 10.0 17.0 22.7 12.8 15.9 16.3 14.0 13.3 14.4 14.9 13.0 14.9 15.0 9.6 18.1 14.7 6.8 17.7 13.8 5.9 6.3 7.5 7.6 5.9 6.5 6.0 5.8 6.3 6.3 6.0 8.4 8.0 19.2 10.8 14.0 16.2 4.5 7.7 6.8 4.6 9.5 4.8 3.9 8.0 5.7 11.3 5.5 4.2 10.4 13.5 4.3 7.9 6.0 23.6 6.8 6.4 8.3 4.2 11.2 26.8 7.7 11.0 6.7 4.6 6.3 17.7 8.3 7.5 5.9 9.5 10.1 24.3 4.2 10.2 13.1 5.7 5.3 6.8 11.3 8.8 14.0 15.5 5.1 19.6 18.6 24.0 7.2 6.7 4.1 11.3 5.3 4.5 6.2 12.5 12.3 0.0 8.4 6.9 18.4 12.2 5.8 7.7 10.9 12.8 6.7 5.3 4.4 CX3CR1 "CCRL1, CMKBRL1, CMKDR1, GPR13, V28" ENSG00000168329 "C-X3-C motif chemokine receptor 1" P49238 3 39263495-39281735 "Disease related genes, G-protein coupled receptors, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Adaptive immunity, Host-virus interaction, Immunity, Inflammatory response, Innate immunity" "G-protein coupled receptor, Receptor, Transducer" "Age-related macular degeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 26.4" "Group enriched" "Detected in some" 5 "Microglial cells: 177.1;NK-cells: 350.1" "Cancer enriched" "Detected in many" 4 "glioma: 21.1" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "non-classical monocyte: 449.2" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in some" 21 "RPMI-8226: 589.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032478, HPA046587" Approved Approved "Plasma membrane" NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 25: RPMI-8226 - Immune response" "Cluster 63: NK-cells & T-cells - Immune response" "Plasma membrane" "CAB032478: AB_638830, HPA046587: AB_2679708" "unprognostic (2.00e-1)" "unprognostic (5.12e-2)" "unprognostic (2.65e-1)" "unprognostic (2.42e-2)" "unprognostic (6.52e-2)" "unprognostic (3.01e-3)" "unprognostic (2.64e-1)" "unprognostic (1.16e-2)" "unprognostic (3.98e-2)" "unprognostic (1.57e-3)" "unprognostic (1.13e-2)" "unprognostic (1.04e-1)" "unprognostic (3.05e-2)" "unprognostic (1.36e-2)" "unprognostic (8.59e-2)" "unprognostic (7.71e-3)" "unprognostic (1.12e-1)" 2.3 3.8 6.2 6.9 6.4 1.1 5.1 8.6 6.0 2.7 1.7 1.1 1.2 2.7 4.2 0.8 6.1 2.6 2.4 7.7 8.4 2.5 2.0 9.9 2.1 17.3 14.8 1.6 0.7 4.5 1.0 4.6 18.9 3.5 1.1 0.5 7.6 7.2 6.5 2.3 0.9 3.5 21.5 11.9 1.4 1.8 17.4 2.0 2.4 2.2 5.3 2.4 0.3 26.4 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.5 0.2 6.8 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.3 0.0 0.0 0.7 0.0 24.5 0.0 0.2 0.2 0.5 0.1 0.0 0.0 0.2 0.1 589.8 0.0 0.0 0.1 0.1 0.0 8.1 0.0 0.2 0.1 16.5 0.0 0.0 0.1 0.1 0.0 0.5 1.0 0.1 0.0 28.6 0.0 7.7 99.6 1.8 264.0 261.2 3.4 0.8 55.9 145.2 94.4 0.7 19.0 122.4 20.8 39.7 449.2 7.1 1.5 232.7 6.2 6.4 8.6 6.0 7.7 8.4 17.3 14.8 18.9 21.5 17.4 26.4 0.8 0.0 0.5 0.7 0.7 0.5 0.0 0.0 0.0 0.0 0.8 3.8 0.4 0.0 0.6 0.0 0.0 0.0 44.3 0.0 0.0 0.0 0.2 0.2 0.1 3.5 0.0 2.1 0.3 0.0 0.0 0.3 0.0 0.0 5.1 0.1 0.7 0.3 4.1 0.0 0.6 0.0 0.0 15.0 28.0 0.3 0.3 43.2 0.0 177.1 50.3 0.1 350.1 2.0 0.4 0.0 0.0 0.0 1.4 0.0 0.0 0.4 0.7 0.2 6.6 0.4 1.3 0.7 0.2 0.0 0.6 0.0 22.6 0.1 0.1 0.0 CYFIP2 PIR121 ENSG00000055163 "Cytoplasmic FMR1 interacting protein 2" Q96F07 5 157266079-157395595 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Apoptosis, Cell adhesion" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 112.2;kidney: 139.9" "Cell type enhanced" "Detected in many" "Astrocytes: 133.5;Collecting duct cells: 158.2;Distal tubular cells: 174.1;Excitatory neurons: 117.7;Inhibitory neurons: 147.5;Oligodendrocyte precursor cells: 120.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Daudi: 202.4;JURKAT: 145.2;MOLT-4: 204.8;U-266/70: 153.6;U-698: 142.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB055519, HPA068106, HPA071459" Uncertain Approved "Endoplasmic reticulum,Plasma membrane,Cytosol" NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 59: Non-specific - Transcription" "Endoplasmic reticulum" "Plasma membrane, Cytosol" "CAB055519: , HPA068106: AB_2685955, HPA071459: AB_2686400" "unprognostic (1.02e-2)" "unprognostic (1.30e-1)" "unprognostic (7.07e-2)" "prognostic unfavorable (2.42e-6)" "unprognostic (3.76e-1)" "unprognostic (4.58e-2)" "unprognostic (1.14e-1)" "unprognostic (6.91e-3)" "unprognostic (3.97e-2)" "unprognostic (5.25e-2)" "prognostic favorable (1.18e-4)" "unprognostic (3.81e-2)" "prognostic favorable (3.21e-12)" "unprognostic (2.90e-1)" "unprognostic (1.38e-1)" "unprognostic (3.03e-1)" "unprognostic (2.49e-2)" 3.2 12.3 61.0 30.8 54.4 55.5 2.8 23.6 103.8 3.1 16.3 8.9 6.3 6.6 25.1 3.8 9.2 8.8 10.4 112.2 25.6 139.9 18.3 12.2 57.1 8.4 33.4 4.8 7.1 64.9 40.1 9.3 6.6 5.8 9.8 35.4 4.0 5.0 7.0 2.8 17.5 5.6 0.0 35.0 20.9 5.3 67.7 85.9 9.9 1.7 55.3 8.3 2.3 37.7 0.3 31.8 47.3 28.8 1.1 1.3 81.5 6.1 9.6 2.5 6.8 6.2 0.6 202.4 14.5 3.4 7.4 0.4 38.0 27.1 5.8 48.8 60.8 28.4 42.3 24.9 4.1 29.1 71.8 5.4 10.9 8.1 0.5 18.8 8.8 145.2 0.4 81.1 7.0 7.7 204.8 5.5 22.3 0.5 8.5 50.6 1.4 102.3 24.5 30.2 70.5 27.4 0.6 28.3 4.6 46.8 19.9 0.8 11.3 2.0 21.4 7.1 5.4 153.6 40.2 142.8 21.4 33.5 11.8 64.8 12.6 90.1 85.9 57.4 61.0 35.8 60.6 75.7 17.8 35.9 63.2 73.2 41.0 53.9 133.7 43.9 53.5 78.0 61.0 54.4 23.6 103.8 112.2 25.6 8.4 33.4 6.6 0.0 67.7 37.7 1.8 3.2 26.9 133.5 76.6 1.1 2.2 2.8 3.4 62.0 3.5 3.4 17.9 8.6 7.4 158.2 16.7 37.2 78.8 6.0 174.1 9.7 15.3 2.8 1.8 2.6 14.4 11.6 117.7 1.6 43.0 3.6 6.1 6.2 2.5 23.1 5.7 30.8 5.3 90.9 147.5 5.6 4.1 6.5 11.4 24.2 1.8 15.7 7.2 23.4 20.3 14.0 101.0 120.6 33.8 1.9 9.9 6.8 41.1 1.3 5.4 55.0 4.7 35.2 0.0 12.2 11.0 3.2 13.1 0.8 1.4 21.1 88.8 2.1 9.1 1.7 CYP2U1 "SPG49, SPG56" ENSG00000155016 "Cytochrome P450 family 2 subfamily U member 1" Q7Z449 4 107931549-107953461 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Monooxygenase, Oxidoreductase" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "lymphoid tissue: 84.9" "Cell type enhanced" "Detected in many" "Excitatory neurons: 30.2;Inhibitory neurons: 34.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "non-classical monocyte: 2.8" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041622, HPA046754, HPA064827" Uncertain Approved "Nucleoplasm,Golgi apparatus,Vesicles" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 63: T-cells - Adaptive immune response" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Golgi apparatus" "Nucleoplasm, Vesicles" "HPA041622: AB_2677583, HPA046754: AB_2679787, HPA064827: AB_2685362" "unprognostic (3.54e-1)" "unprognostic (2.45e-1)" "unprognostic (3.08e-1)" "unprognostic (2.84e-1)" "unprognostic (5.16e-2)" "unprognostic (1.08e-1)" "unprognostic (1.36e-2)" "unprognostic (1.20e-3)" "unprognostic (3.19e-1)" "unprognostic (8.97e-3)" "unprognostic (5.41e-3)" "unprognostic (3.02e-1)" "prognostic favorable (2.75e-5)" "prognostic unfavorable (6.97e-4)" "unprognostic (1.19e-1)" "unprognostic (1.17e-2)" "unprognostic (1.11e-1)" 7.7 6.4 6.6 4.0 8.3 0.5 4.5 7.6 7.3 5.1 10.1 5.8 3.4 6.6 3.6 3.5 7.8 5.6 7.7 6.5 8.7 5.3 5.9 5.7 6.3 9.0 7.9 9.5 2.3 10.7 4.7 2.4 8.2 9.9 3.9 5.8 3.4 8.7 3.6 2.7 4.7 10.2 8.1 7.6 3.2 3.0 8.0 84.9 3.6 7.2 4.7 4.7 3.8 9.5 4.0 1.9 5.2 9.5 28.6 13.4 0.8 16.8 25.3 10.2 15.7 0.1 2.5 10.8 1.1 10.1 7.8 0.2 8.1 6.4 15.4 3.0 2.5 2.3 3.5 0.5 11.3 3.2 0.0 15.3 5.3 4.7 3.2 20.8 4.0 12.0 0.1 5.0 8.4 2.9 11.8 0.0 5.4 0.4 4.7 6.5 6.3 0.1 3.3 6.7 10.0 7.6 4.2 7.3 18.6 4.3 3.6 1.5 10.6 6.5 0.8 9.3 6.9 21.1 21.2 3.4 5.5 0.0 7.4 0.0 0.1 0.3 0.4 0.5 0.3 0.8 0.3 0.4 0.9 1.1 0.7 0.5 0.0 0.7 2.8 1.1 0.0 0.2 6.6 8.3 7.6 7.3 6.5 8.7 9.0 7.9 8.2 8.1 8.0 9.5 5.5 3.2 3.9 18.6 12.9 1.1 4.6 2.2 15.4 4.1 2.8 5.8 6.2 1.5 2.4 9.2 4.2 0.4 10.1 1.4 0.0 0.9 13.2 6.9 6.3 5.8 3.0 1.7 30.2 2.0 0.3 12.6 3.1 6.2 4.5 2.5 8.6 7.3 2.3 1.7 34.3 1.2 0.0 6.2 3.3 9.5 17.7 4.7 19.6 5.6 3.7 9.5 1.0 20.1 12.1 0.4 0.1 17.7 4.2 1.5 9.9 3.0 8.6 3.1 0.0 20.0 8.1 1.0 4.2 2.0 1.4 0.3 3.6 5.1 3.1 0.8 CYP4V2 CYP4AH1 ENSG00000145476 "Cytochrome P450 family 4 subfamily V member 2" Q6ZWL3 4 186191567-186213463 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Lipid metabolism, Sensory transduction, Vision" "Monooxygenase, Oxidoreductase" "Corneal dystrophy, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 113.5" "Cell type enhanced" "Detected in many" "Hepatocytes: 103.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "ASC diff: 15.2;SK-MEL-30: 27.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029122 Approved Approved "Nuclear speckles" NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 85: Liver - Metabolism" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 2: Hepatocytes - Metabolism" "Nuclear speckles" "HPA029122: AB_10601806" "unprognostic (1.65e-1)" "unprognostic (5.37e-2)" "unprognostic (2.35e-1)" "prognostic favorable (5.86e-4)" "unprognostic (1.45e-1)" "unprognostic (1.02e-1)" "prognostic favorable (1.85e-4)" "unprognostic (6.66e-2)" "unprognostic (5.84e-2)" "unprognostic (2.05e-1)" "unprognostic (6.49e-2)" "unprognostic (9.89e-2)" "prognostic favorable (1.49e-7)" "unprognostic (3.25e-2)" "unprognostic (8.96e-2)" "unprognostic (1.02e-1)" "unprognostic (3.14e-2)" 7.4 16.4 5.1 5.2 6.8 2.1 5.7 5.6 5.0 8.6 17.9 9.6 16.5 5.6 2.6 5.0 6.1 14.7 9.2 4.8 5.1 33.9 113.5 10.8 5.6 5.3 6.0 5.7 15.6 33.4 3.7 3.5 5.3 8.2 11.9 14.2 7.0 7.5 4.5 1.3 16.7 7.1 5.4 11.2 6.2 3.2 5.6 6.5 17.3 5.0 4.9 6.4 2.3 6.3 3.4 1.8 0.8 0.0 15.2 6.3 0.2 4.4 9.9 1.7 1.9 0.0 13.0 1.1 0.5 3.5 5.9 1.6 1.9 1.7 0.3 6.0 2.2 4.7 0.8 0.5 5.6 2.6 1.9 5.8 0.8 1.9 1.0 5.9 0.1 6.4 1.4 14.3 6.8 2.9 3.6 1.3 1.5 1.6 0.0 3.1 0.7 1.0 7.4 6.1 4.0 4.9 1.1 0.0 27.5 0.3 2.6 4.6 4.1 3.6 0.7 3.5 1.6 0.1 0.0 0.5 10.9 11.0 4.7 0.0 0.6 0.0 1.8 1.9 1.0 0.4 1.4 1.8 0.7 1.0 1.3 1.3 0.0 0.8 3.1 1.3 1.1 0.9 5.1 6.8 5.6 5.0 4.8 5.1 5.3 6.0 5.3 5.4 5.6 6.3 9.0 6.4 11.5 31.3 13.8 2.5 4.5 5.1 9.6 33.6 9.3 7.2 18.8 42.9 8.7 14.7 31.3 2.0 9.6 14.7 9.8 24.2 2.7 6.7 5.1 7.7 16.9 16.4 15.4 22.4 2.1 14.2 12.8 7.6 7.0 6.5 8.9 103.7 13.5 5.0 23.4 16.5 2.0 14.8 6.0 2.1 5.0 11.3 3.6 6.5 3.5 52.2 4.1 15.6 11.0 9.6 9.0 6.4 12.3 3.8 47.2 28.5 11.9 27.4 0.0 10.1 10.6 8.9 6.3 6.8 3.1 1.0 17.2 6.7 10.5 5.7 CYP7B1 SPG5A ENSG00000172817 "Cytochrome P450 family 7 subfamily B member 1" O75881 8 64587763-64798737 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol metabolism" "Monooxygenase, Oxidoreductase" "Disease variant, Hereditary spastic paraplegia, Intrahepatic cholestasis, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 27.2" "Cell type enhanced" "Detected in many" "Astrocytes: 93.7;Oligodendrocyte precursor cells: 94.5;Oligodendrocytes: 119.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 11 "basophil: 2.5;eosinophil: 1.5" "Lineage enriched" "Detected in single" 25 "granulocytes: 2.5" "Group enriched" "Detected in some" 4 "HSkMC: 16.5;SH-SY5Y: 5.5;WM-115: 10.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017761 Uncertain NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 17: WM-115 - Nervous system development" "Cluster 68: Oligodendrocytes - Mixed function" "HPA017761: AB_1847455" "unprognostic (3.19e-2)" "unprognostic (1.91e-1)" "unprognostic (1.50e-1)" "unprognostic (6.89e-3)" "unprognostic (1.07e-1)" "unprognostic (5.80e-3)" "unprognostic (3.80e-1)" "unprognostic (5.50e-2)" "unprognostic (6.11e-3)" "unprognostic (2.46e-1)" "unprognostic (1.61e-1)" "unprognostic (3.19e-2)" "unprognostic (1.87e-2)" "unprognostic (2.38e-3)" "unprognostic (4.00e-1)" "unprognostic (3.04e-3)" "unprognostic (6.75e-3)" 8.4 5.4 5.7 5.6 11.4 0.3 6.3 8.2 6.6 5.7 8.6 2.3 1.8 2.8 2.0 7.3 2.7 5.8 3.6 5.3 6.8 7.9 21.5 4.6 2.4 11.8 7.3 4.2 6.7 11.4 0.8 0.5 11.4 4.4 3.5 1.9 4.6 5.6 0.2 5.9 1.8 4.3 8.4 9.2 2.4 1.7 8.1 2.1 12.2 1.7 2.9 7.9 3.0 27.2 1.5 0.6 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.1 0.0 0.2 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.4 0.0 0.0 16.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.5 0.0 1.6 5.5 0.0 0.0 2.2 0.8 0.0 1.4 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.3 2.5 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 5.7 11.4 8.2 6.6 5.3 6.8 11.8 7.3 11.4 8.4 8.1 27.2 3.3 0.0 3.4 93.7 0.1 10.6 6.6 1.0 7.4 4.9 4.2 5.5 3.0 2.8 0.9 7.3 2.1 0.1 0.4 0.0 3.9 4.4 7.4 0.2 6.9 2.1 1.8 1.3 29.3 4.9 0.2 15.9 0.5 0.1 12.7 0.6 2.5 8.2 0.2 3.3 30.6 0.5 0.0 0.3 4.9 8.6 5.9 0.5 17.8 30.0 1.0 6.9 0.0 94.5 119.2 1.2 0.0 4.9 0.0 4.2 0.0 2.9 0.8 0.5 13.1 1.1 16.8 4.1 3.4 6.2 12.6 0.0 1.3 7.6 0.0 3.1 DAB1 ENSG00000173406 "DAB adaptor protein 1" O75553 1 56994778-58546734 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Differentiation, Neurogenesis" "Developmental protein" "Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 16.8;intestine: 22.3;seminal vesicle: 10.0" "Group enriched" "Detected in some" 8 "Excitatory neurons: 460.3;Inhibitory neurons: 1170.3;Oligodendrocyte precursor cells: 814.8" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "MAIT T-cell: 2.1" "Lineage enhanced" "Detected in single" "T-cells: 2.1" "Cell line enhanced" "Detected in some" "fHDF/TERT166: 54.0;HeLa: 18.6;NTERA-2: 23.4;RT4: 32.0;WM-115: 26.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032329, HPA052033, HPA067495" Enhanced Enhanced Vesicles NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles "CAB032329: AB_638973, HPA052033: AB_2681703, HPA067495: AB_2685852" "unprognostic (7.88e-2)" "unprognostic (1.02e-1)" "unprognostic (8.54e-2)" "unprognostic (2.09e-4)" "unprognostic (1.21e-1)" "unprognostic (1.18e-1)" "unprognostic (7.30e-4)" "unprognostic (3.90e-1)" "unprognostic (3.07e-2)" "unprognostic (1.47e-2)" "unprognostic (2.06e-3)" "unprognostic (1.27e-1)" "unprognostic (2.00e-3)" "unprognostic (1.78e-1)" "unprognostic (2.01e-1)" "unprognostic (1.44e-2)" "unprognostic (5.67e-2)" 2.0 1.7 4.3 0.4 5.3 0.0 0.3 16.8 8.8 1.6 0.0 0.8 15.8 0.5 0.4 0.6 1.6 0.7 1.8 10.6 5.4 0.3 7.7 0.4 0.2 2.1 3.9 1.2 0.4 0.0 0.2 0.0 2.0 3.9 0.3 5.4 0.9 10.0 0.1 0.1 22.3 0.3 2.3 0.2 1.0 0.4 5.1 0.1 0.3 0.1 0.1 1.2 0.9 1.9 0.0 0.0 10.6 0.0 0.1 0.2 0.0 1.5 0.0 0.0 0.0 0.1 0.0 0.1 0.0 54.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 18.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.8 0.0 0.0 0.0 0.0 2.0 0.1 23.4 0.0 0.0 6.0 0.0 0.2 0.0 32.0 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 0.3 0.1 0.1 0.0 0.0 0.0 0.0 0.0 26.6 0.0 0.0 0.6 0.1 0.0 2.1 0.0 0.7 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 4.3 5.3 16.8 8.8 10.6 5.4 2.1 3.9 2.0 2.3 5.1 1.9 0.7 0.0 0.0 30.0 0.1 0.0 0.1 0.1 0.0 23.7 0.1 0.3 3.2 0.0 0.1 0.0 0.0 0.0 0.2 0.1 0.0 0.0 8.6 8.2 0.6 0.3 0.0 0.0 460.3 0.0 0.0 0.4 4.6 12.8 0.0 0.0 0.7 5.1 0.1 21.9 1170.3 1.9 6.1 0.3 0.0 4.7 3.4 0.1 0.0 22.5 0.0 1.0 1.0 814.8 26.5 0.0 0.0 2.6 0.0 0.1 101.1 0.2 0.0 0.8 0.0 0.1 0.9 0.2 0.5 0.0 0.0 0.7 0.6 0.0 2.1 0.0 DALRD3 FLJ10496 ENSG00000178149 "DALR anticodon binding domain containing 3" Q5D0E6 3 49015488-49022293 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 158.9;Late spermatids: 306.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036862 Approved Approved "Nucleoplasm,Nuclear bodies,Cytosol" NA NA "Cluster 35: T-regs - Unknown function" "Cluster 22: Non-specific - Unknown function" "Cluster 25: RPMI-8226 - Immune response" "Cluster 31: Spermatids - Spermatogenesis" Nucleoplasm "Nuclear bodies, Cytosol" "HPA036862: AB_10673507" "unprognostic (2.76e-2)" "unprognostic (8.44e-3)" "unprognostic (3.56e-1)" "prognostic favorable (9.03e-4)" "unprognostic (3.77e-1)" "unprognostic (1.52e-1)" "unprognostic (3.33e-3)" "unprognostic (1.19e-2)" "unprognostic (5.33e-2)" "unprognostic (9.52e-2)" "unprognostic (8.07e-2)" "unprognostic (1.11e-1)" "prognostic favorable (2.79e-5)" "unprognostic (1.18e-1)" "unprognostic (1.75e-1)" "unprognostic (1.15e-2)" "unprognostic (2.18e-1)" 11.8 18.5 11.2 6.0 10.9 5.4 14.2 10.6 12.4 14.1 14.5 10.1 7.8 9.8 13.1 18.3 36.9 10.5 10.0 10.8 10.8 21.4 9.0 9.9 9.1 11.5 12.6 15.2 38.7 13.9 14.4 9.6 10.9 10.2 7.9 6.5 11.6 9.5 11.0 18.8 9.6 6.9 12.0 10.8 14.7 51.0 11.2 9.4 19.2 6.9 12.3 10.7 11.5 10.8 12.0 16.6 10.2 20.0 28.5 37.8 12.4 9.9 27.5 16.5 15.8 11.7 14.9 4.9 13.7 27.3 14.3 7.8 13.4 26.1 11.5 7.0 9.1 5.3 13.9 22.0 18.7 15.0 10.5 25.7 26.6 20.9 46.1 42.0 26.0 11.2 4.3 12.0 16.4 20.8 6.6 10.1 16.8 25.3 15.5 3.5 1.5 35.7 44.4 19.0 6.5 21.1 10.9 30.1 23.7 16.8 21.3 16.2 15.9 6.4 9.7 22.6 9.2 37.8 21.9 3.0 24.2 8.3 12.9 12.0 11.1 5.5 13.9 13.7 25.0 23.9 22.4 17.1 11.7 21.1 18.7 12.5 10.9 22.6 12.8 8.1 29.5 12.8 11.2 10.9 10.6 12.4 10.8 10.8 11.5 12.6 10.9 12.0 11.2 10.8 26.8 16.0 12.2 8.5 27.3 25.6 21.6 28.5 22.8 30.2 35.5 40.5 1.2 27.1 20.8 27.6 18.8 28.2 30.0 25.0 37.2 40.7 158.9 61.2 21.5 16.3 19.1 11.1 10.7 39.4 40.0 19.8 28.5 24.6 24.7 32.4 15.0 5.9 19.2 40.4 9.5 22.3 20.3 12.9 24.5 306.6 24.2 16.8 21.4 2.8 23.5 25.8 13.4 6.6 5.5 21.5 21.3 18.4 18.2 10.0 50.4 49.9 75.3 58.4 46.0 19.1 19.0 110.7 33.4 26.5 34.1 18.3 27.1 29.7 30.0 17.3 DARS2 "FLJ10514, mtAspRS" ENSG00000117593 "Aspartyl-tRNA synthetase 2, mitochondrial" Q6PI48 1 173824653-173858808 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Protein biosynthesis" "Aminoacyl-tRNA synthetase, Ligase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026506, HPA026528" Enhanced Supported Nucleoplasm,Mitochondria NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Mitochondria Nucleoplasm "HPA026506: AB_1847482, HPA026528: AB_1847483" "unprognostic (3.14e-2)" "unprognostic (1.52e-1)" "unprognostic (1.06e-1)" "unprognostic (8.85e-3)" "unprognostic (1.33e-1)" "unprognostic (1.14e-2)" "unprognostic (1.05e-3)" "unprognostic (4.10e-3)" "unprognostic (2.20e-1)" "unprognostic (1.42e-1)" "unprognostic (6.17e-2)" "unprognostic (1.15e-1)" "prognostic favorable (1.74e-4)" "unprognostic (3.30e-1)" "unprognostic (1.90e-1)" "unprognostic (1.13e-1)" "unprognostic (4.73e-3)" 8.8 9.8 3.1 7.6 3.5 5.4 7.5 3.7 4.3 7.1 11.5 14.6 8.7 4.3 4.7 6.4 5.2 4.8 8.4 3.1 3.8 19.9 13.5 5.7 9.2 3.3 3.6 4.4 5.7 15.5 2.9 7.6 3.4 5.3 15.4 5.2 5.2 5.0 5.6 3.4 10.4 5.6 3.5 6.2 9.3 6.2 3.9 10.6 7.6 13.5 12.0 6.7 4.1 3.7 74.8 50.5 26.3 18.7 24.0 34.2 38.6 32.3 30.0 49.2 37.0 47.5 68.2 41.6 45.2 27.2 31.3 77.5 86.6 56.5 66.7 48.6 41.5 35.2 22.7 31.8 24.0 30.9 30.8 23.2 25.3 50.9 44.5 15.4 49.8 30.5 74.7 31.0 39.6 19.9 38.8 16.1 60.2 83.0 63.2 44.3 40.6 78.2 43.7 24.9 40.4 34.2 36.3 79.6 51.3 47.0 84.5 39.7 21.2 22.9 35.3 32.6 52.5 21.7 60.4 46.3 13.3 33.3 51.5 3.9 4.4 3.3 3.8 7.0 5.4 6.0 3.4 3.2 6.4 4.4 3.8 2.6 0.2 3.5 5.0 2.5 3.9 3.5 3.1 3.5 3.7 4.3 3.1 3.8 3.3 3.6 3.4 3.5 3.9 3.7 3.7 3.2 3.1 7.2 5.7 1.8 4.1 3.1 6.2 2.3 3.3 2.5 12.6 4.3 4.2 5.5 0.0 9.7 3.1 4.8 7.9 3.9 2.5 3.9 4.9 4.5 4.2 9.4 5.3 2.7 16.0 3.9 7.1 4.5 5.7 4.5 1.8 5.4 10.3 3.3 6.5 5.2 0.0 4.4 2.2 1.5 3.1 5.1 1.8 8.4 5.6 2.9 3.1 4.0 5.1 3.8 1.9 1.5 7.1 2.6 5.9 7.1 3.0 2.7 0.0 6.2 4.0 8.9 7.1 8.0 1.6 4.2 4.4 9.2 7.2 2.9 DBH DBM ENSG00000123454 "Dopamine beta-hydroxylase" P09172 9 133636363-133659329 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Catecholamine biosynthesis" "Monooxygenase, Oxidoreductase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 7 "adrenal gland: 272.7;brain: 236.6" "Cell type enriched" "Detected in some" 6 "Hepatic stellate cells: 10.0" "Cancer enhanced" "Detected in some" "liver cancer: 1.7" "Region enriched" "Detected in many" 8 "pons: 236.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 346 "SH-SY5Y: 1826.4" "Region enriched" "Detected in some" 6 "pons and medulla: 22.1" "Region enriched" "Detected in single" 26 "pons: 18.5" "HPA002130, HPA005960, HPA070789" Enhanced Supported "Endoplasmic reticulum,Vesicles" "Intracellular and membrane" NA NA 1600000000 "Cluster 32: T-cells - Unknown function" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 43: Cardiomyocytes - Nuclear processes" Vesicles "Endoplasmic reticulum" "HPA002130: AB_2666554, HPA005960: AB_1078628, HPA070789: AB_2686312" "unprognostic (1.93e-3)" "unprognostic (7.52e-3)" "unprognostic (8.53e-2)" "unprognostic (2.10e-2)" "unprognostic (2.18e-3)" "unprognostic (3.38e-3)" "unprognostic (3.39e-3)" "unprognostic (3.97e-2)" "unprognostic (1.71e-1)" "unprognostic (8.99e-2)" "unprognostic (5.80e-2)" "unprognostic (7.69e-2)" "unprognostic (2.81e-7)" "unprognostic (9.31e-2)" "unprognostic (6.77e-2)" "unprognostic (1.49e-2)" "unprognostic (5.06e-3)" 2.8 272.7 0.1 1.0 0.2 0.2 0.1 0.0 0.8 0.4 0.0 0.1 0.4 0.3 0.2 0.1 0.3 0.3 0.5 0.3 0.2 1.3 36.1 0.8 2.3 9.8 29.4 0.4 4.3 0.0 1.4 1.4 236.6 0.4 0.0 0.1 0.6 0.2 0.1 0.2 0.6 0.0 0.0 0.9 0.4 0.2 0.6 0.2 0.4 0.0 0.0 0.4 1.1 1.0 0.0 0.0 0.1 0.9 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.2 3.2 0.9 0.1 0.0 0.0 0.3 5.2 4.7 0.0 0.0 2.1 1826.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.4 0.2 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.8 0.3 0.2 9.8 29.4 236.6 0.0 0.6 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 10.0 0.1 0.0 0.0 0.1 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 1.0 0.0 0.0 DCAF8 "FLJ35857, H326, WDR42A" ENSG00000132716 "DDB1 and CUL4 associated factor 8" Q5TAQ9 1 160215715-160262549 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Ubl conjugation pathway" "Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027218, HPA027381" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 16: U-266 - Nucleosome" "Cluster 59: Non-specific - Transcription" Nucleoplasm Cytosol "HPA027218: AB_10602586, HPA027381: AB_1858808" "unprognostic (3.47e-1)" "unprognostic (1.86e-1)" "unprognostic (4.39e-3)" "unprognostic (1.02e-2)" "unprognostic (2.25e-1)" "unprognostic (1.87e-2)" "unprognostic (3.29e-1)" "unprognostic (1.87e-2)" "unprognostic (3.13e-2)" "unprognostic (9.34e-3)" "prognostic favorable (4.71e-4)" "unprognostic (5.42e-2)" "prognostic unfavorable (3.74e-5)" "unprognostic (3.30e-1)" "unprognostic (7.42e-2)" "unprognostic (3.98e-1)" "unprognostic (1.56e-3)" 63.3 62.6 35.3 47.0 43.3 54.6 60.6 47.7 52.8 55.8 47.1 72.0 56.6 60.4 76.2 50.2 58.9 53.5 85.1 33.7 41.8 55.8 103.4 50.9 60.5 39.2 37.3 62.2 80.2 85.7 66.3 45.1 37.0 53.6 40.6 106.7 60.6 53.2 219.7 67.2 61.8 44.0 32.6 65.6 67.3 40.7 41.1 67.5 77.9 118.3 51.1 61.1 49.8 53.0 54.2 62.5 72.0 64.8 86.3 65.5 63.7 62.7 81.8 49.5 42.2 69.8 89.6 56.3 112.1 67.2 34.6 64.8 34.6 57.4 31.0 134.9 69.0 63.4 99.7 54.1 69.3 52.9 80.3 74.6 58.9 44.2 60.8 55.3 73.5 73.1 60.6 98.4 46.0 50.0 71.7 54.5 52.7 70.1 62.6 69.2 41.8 115.5 57.7 87.6 49.0 47.3 101.8 113.1 68.2 68.9 104.9 82.0 95.1 60.7 31.5 38.6 58.7 169.8 124.9 94.3 68.7 49.6 51.2 32.9 21.5 22.0 31.5 19.7 29.6 28.5 27.0 29.2 17.5 30.4 29.4 27.0 24.9 30.4 28.4 22.0 30.4 19.2 35.3 43.3 47.7 52.8 33.7 41.8 39.2 37.3 37.0 32.6 41.1 53.0 21.4 57.7 54.9 57.5 35.4 18.4 16.3 17.3 38.7 44.6 27.5 21.8 54.2 30.0 30.5 25.8 64.6 30.9 26.4 20.4 62.6 23.9 3.6 26.6 18.9 26.4 25.1 48.4 53.7 21.6 21.0 28.9 35.2 21.4 34.1 21.2 21.4 77.6 23.8 40.4 49.5 19.2 20.3 29.8 18.9 4.3 28.0 24.2 14.2 39.4 27.6 38.1 18.6 58.8 93.1 19.2 13.6 32.7 45.3 16.3 29.0 38.1 40.5 60.5 13.1 29.5 26.6 28.0 20.4 35.1 24.2 44.3 36.5 25.6 18.8 12.5 DCC "IGDCC1, NTN1R1" ENSG00000187323 "DCC netrin 1 receptor" P43146 18 52340197-53535903 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" Apoptosis "Developmental protein, Receptor" "Cancer-related genes, Disease variant, Mental retardation, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 6.9;testis: 7.6" "Cell type enhanced" "Detected in some" "Early spermatids: 205.7;Excitatory neurons: 439.7;Inhibitory neurons: 455.8;Late spermatids: 174.9;Oligodendrocyte precursor cells: 1305.9" "Cancer enhanced" "Detected in single" "glioma: 0.9" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "AF22: 36.4;U-266/70: 112.5;U-266/84: 57.1" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA055376, HPA069552" Enhanced Approved "Golgi apparatus" NA NA 64000 "Cluster 78: Testis - Spermatogenesis" "Cluster 29: U-266 - Adaptive immune response" "Cluster 68: Oligodendrocytes - Mixed function" "Golgi apparatus" "HPA055376: AB_2682798, HPA069552: AB_2686151" "unprognostic (1.96e-3)" "unprognostic (1.69e-2)" "unprognostic (3.13e-1)" "unprognostic (3.90e-3)" "unprognostic (1.04e-1)" "unprognostic (1.35e-3)" "unprognostic (2.59e-1)" "unprognostic (5.59e-2)" "unprognostic (2.00e-1)" "unprognostic (2.58e-1)" "unprognostic (8.22e-4)" "unprognostic (4.14e-2)" "unprognostic (1.27e-4)" "unprognostic (7.21e-2)" "unprognostic (1.84e-2)" "unprognostic (1.42e-1)" "unprognostic (2.69e-3)" 0.0 0.6 1.2 0.2 6.3 0.0 0.0 0.0 3.9 0.3 0.0 0.2 0.0 0.0 0.2 0.1 0.1 0.0 0.0 6.9 3.6 0.2 0.0 1.4 0.0 0.7 4.7 0.1 0.3 0.0 0.6 0.0 1.5 0.3 0.1 0.3 0.1 1.2 0.0 0.1 0.1 0.0 0.0 0.2 0.2 7.6 1.1 1.0 0.0 0.0 0.3 0.1 0.1 0.9 0.1 0.1 36.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.7 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.4 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.2 0.0 0.1 112.5 57.1 0.0 6.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 6.3 0.0 3.9 6.9 3.6 0.7 4.7 1.5 0.0 1.1 0.9 1.4 0.0 6.0 10.1 0.3 0.0 0.1 0.0 0.0 2.5 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 205.7 0.0 0.0 0.1 0.0 0.0 439.7 0.2 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 455.8 0.0 0.0 0.0 0.0 174.9 1.2 0.2 0.0 54.4 0.0 0.2 0.0 1305.9 58.6 0.0 0.0 1.2 5.7 0.2 0.0 0.3 0.0 0.4 0.0 0.0 0.1 2.6 1.7 0.0 0.0 0.1 0.0 0.0 0.0 0.1 DCDC2 "DCDC2A, DFNB66, KIAA1154, NPHP19, RU2" ENSG00000146038 "Doublecortin domain containing 2" Q9UHG0 6 24171755-24358059 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cilium biogenesis/degradation, Neurogenesis" "Ciliopathy, Deafness, Disease variant, Nephronophthisis, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 15.1;kidney: 23.2;pancreas: 26.2" "Cell type enhanced" "Detected in many" "Cholangiocytes: 62.9;Collecting duct cells: 79.1;Distal tubular cells: 56.7;Ductal cells: 135.9;Endometrial ciliated cells: 160.3;Glandular and luminal cells: 102.4;Proximal tubular cells: 54.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CACO-2: 71.8;EFO-21: 48.3;Hep G2: 82.3;RPTEC TERT1: 254.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA031582, HPA031583, HPA031584" Enhanced Supported "Microtubules,Mitotic spindle,Centriolar satellite,Cytosol" Yes NA "Cluster 7: Kidney - Transmembrane transport" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 44: Endometrium - Transcription" Cytosol "Microtubules, Mitotic spindle, Centriolar satellite" "HPA031582: AB_10600901, HPA031583: AB_2673944, HPA031584: AB_2673945" "unprognostic (8.65e-2)" "unprognostic (2.07e-2)" "unprognostic (1.66e-1)" "unprognostic (6.70e-2)" "unprognostic (1.08e-2)" "unprognostic (3.22e-1)" "unprognostic (1.03e-1)" "unprognostic (1.45e-1)" "unprognostic (2.90e-1)" "unprognostic (7.87e-2)" "unprognostic (1.81e-1)" "unprognostic (1.09e-1)" "unprognostic (2.67e-2)" "unprognostic (5.22e-2)" "unprognostic (1.16e-1)" "unprognostic (2.12e-2)" "unprognostic (2.99e-2)" 0.0 1.3 0.8 0.0 1.2 0.1 4.4 0.3 0.8 1.6 15.1 0.7 0.6 4.4 5.3 0.0 7.6 3.9 0.0 0.8 1.0 23.2 2.2 3.4 0.0 2.2 2.7 0.2 26.2 8.2 1.2 0.6 1.7 1.2 0.6 1.4 0.4 2.3 0.3 0.1 0.1 0.1 2.0 0.1 1.8 3.7 1.1 0.1 8.2 0.2 0.0 0.4 0.0 1.6 0.0 8.8 0.5 0.1 0.0 0.0 0.2 0.0 0.1 0.0 0.0 71.8 0.2 0.0 48.3 0.0 0.1 0.0 0.0 0.1 0.1 0.0 8.2 0.0 0.0 82.3 0.0 0.0 0.0 0.0 0.0 9.7 0.0 1.4 0.0 0.2 0.1 0.0 0.3 10.8 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 254.5 0.3 5.2 0.5 0.0 1.3 0.0 0.2 12.3 0.0 0.0 0.0 0.8 0.0 0.0 0.1 0.0 0.5 0.5 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.8 1.2 0.3 0.8 0.8 1.0 2.2 2.7 1.7 2.0 1.1 1.6 0.2 19.2 14.4 3.9 1.4 0.1 0.6 0.3 0.0 0.0 20.3 11.7 0.3 62.9 6.1 79.1 0.0 0.4 0.0 1.2 56.7 135.9 40.1 160.3 5.3 0.4 3.6 0.0 11.3 8.4 0.0 1.3 3.6 102.4 0.0 4.1 0.0 1.0 0.5 0.0 8.3 2.9 0.0 0.0 0.0 14.6 0.3 1.0 0.0 1.0 2.0 2.3 0.0 1.0 0.5 27.9 4.1 0.4 0.0 1.3 0.0 54.3 37.1 0.1 0.0 0.0 2.4 32.3 2.6 0.0 0.1 0.1 1.1 5.6 2.7 0.9 DCN "DSPG2, SLRR1B" ENSG00000011465 Decorin P07585 12 91140484-91183217 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Cancer-related genes, Corneal dystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 1218.7;Fibroblasts: 7960.2;Leydig cells: 6281.9;Peritubular cells: 1856.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 9 "basophil: 24.5" "Lineage enriched" "Detected in single" 35 "granulocytes: 24.5" "Cell line enhanced" "Detected in many" "ASC diff: 3291.1;ASC TERT1: 2371.6;BJ hTERT+: 2546.6;HSkMC: 2289.4" "Low region specificity" "Detected in all" "Region enriched" "Detected in all" 8 "spinal cord: 544.7" "HPA003315, CAB017118, HPA064736, CAB068930" Enhanced "Secreted to extracellular matrix" NA NA 1900000 "Cluster 46: Basophils - DNA binding" "Cluster 46: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "CAB017118: , CAB068930: AB_425394, HPA003315: AB_1078639, HPA064736: AB_2685340" "unprognostic (1.73e-1)" "unprognostic (1.90e-1)" "unprognostic (1.43e-1)" "unprognostic (3.22e-2)" "unprognostic (8.63e-2)" "unprognostic (1.34e-1)" "unprognostic (1.01e-2)" "unprognostic (2.68e-1)" "unprognostic (1.98e-1)" "unprognostic (6.12e-2)" "unprognostic (1.65e-1)" "unprognostic (5.15e-2)" "prognostic unfavorable (1.46e-5)" "unprognostic (3.06e-3)" "unprognostic (5.37e-2)" "unprognostic (1.59e-3)" "unprognostic (7.56e-3)" 1522.3 1171.7 60.6 272.0 80.0 4.4 2342.2 63.5 119.2 1493.0 111.6 549.9 163.5 1308.5 1302.0 932.8 1213.4 1802.7 2108.9 66.8 60.3 394.8 459.6 955.8 130.4 68.9 60.9 2681.4 257.9 80.2 112.0 1534.8 75.7 451.6 493.0 3.1 362.5 462.3 469.0 713.4 336.6 1027.8 70.2 20.0 434.5 279.6 72.8 183.0 479.3 1328.3 293.6 1895.5 783.7 57.9 0.2 0.4 4.4 0.6 3291.1 2371.6 6.2 608.7 2546.6 28.8 28.5 0.3 0.9 1.1 0.5 523.5 0.6 2.1 0.8 1.9 4.9 0.7 0.5 0.6 20.4 0.1 717.4 1.3 1.4 2289.4 8.9 78.3 38.5 12.1 1.0 0.2 0.8 0.7 63.0 0.6 1.5 10.8 1.2 0.4 1.6 0.7 2.3 2.8 3.4 0.5 2.7 11.9 10.3 1.1 0.9 1.8 0.6 0.4 0.9 132.3 1.2 497.5 0.6 3.3 3.1 2.0 8.0 2.0 0.8 24.5 0.3 0.6 0.3 0.1 0.3 0.3 0.3 0.2 0.1 0.6 0.4 0.4 2.7 0.4 0.2 0.7 0.2 0.0 60.6 80.0 63.5 119.2 66.8 60.3 68.9 60.9 75.7 70.2 72.8 57.9 351.1 41.7 44.1 2.3 4.1 609.1 5.4 0.0 264.6 1.9 25.5 31.5 154.7 10.0 11.8 20.2 0.0 31.2 12.8 0.0 1.9 1.0 25.0 39.4 1218.7 158.7 0.0 2.7 0.8 0.0 30.0 7960.2 54.0 22.0 21.5 0.2 214.9 1.4 58.8 0.0 17.1 0.1 0.0 2.8 962.7 103.0 6281.9 52.5 606.5 122.7 0.0 3.3 0.0 0.0 1.4 2.7 0.5 1856.9 23.2 5.8 0.0 0.4 5.8 0.7 210.4 236.8 408.2 13.4 9.2 36.8 482.5 63.9 72.3 70.2 0.0 10.7 DCTN1 ENSG00000204843 "Dynactin subunit 1" Q14203 2 74361154-74392087 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Transport" "Amyotrophic lateral sclerosis, Cancer-related genes, Neurodegeneration, Neuropathy, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009108, HPA034635, HPA071875" Approved Supported "Microtubules,Cytokinetic bridge,Mitotic spindle" Yes No 250000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 80: Striated muscle - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" Microtubules "Cytokinetic bridge, Mitotic spindle" "CAB009108: AB_2090601, HPA034635: AB_2674256, HPA071875: " "unprognostic (1.14e-1)" "unprognostic (7.19e-2)" "unprognostic (1.33e-3)" "unprognostic (4.08e-2)" "unprognostic (1.20e-1)" "unprognostic (2.67e-1)" "unprognostic (4.61e-3)" "unprognostic (2.11e-2)" "unprognostic (2.79e-1)" "unprognostic (3.73e-3)" "unprognostic (1.87e-1)" "unprognostic (2.26e-1)" "prognostic favorable (2.34e-7)" "unprognostic (5.41e-2)" "unprognostic (3.11e-1)" "unprognostic (7.86e-3)" "unprognostic (1.12e-3)" 43.3 40.0 90.5 27.0 94.7 23.7 37.4 76.4 113.2 44.3 20.8 51.3 22.2 51.4 17.0 42.6 38.7 28.2 82.6 99.9 80.1 27.6 18.2 36.0 22.8 110.9 85.1 39.2 28.6 118.0 61.2 32.6 112.6 30.0 25.5 43.5 56.3 38.0 87.6 44.2 32.2 49.9 76.0 26.5 39.5 51.3 101.9 34.7 31.3 63.4 24.6 47.6 39.0 116.2 65.0 74.7 68.4 71.9 122.5 90.7 55.2 102.0 105.2 127.0 89.9 99.9 48.6 88.8 40.8 213.0 70.1 63.5 84.3 129.5 96.1 111.2 85.0 92.5 55.6 84.7 94.4 50.7 109.3 109.6 62.0 138.3 82.3 86.9 110.3 79.4 40.3 61.4 97.3 55.6 92.8 52.5 74.0 78.6 78.3 82.3 120.1 63.8 70.2 39.6 83.3 74.1 57.1 67.7 60.6 59.0 43.5 36.5 84.3 115.0 82.7 50.0 77.2 37.8 32.7 78.9 107.6 81.4 82.5 8.3 11.3 12.7 14.4 13.0 11.7 10.1 8.2 10.8 11.2 6.8 5.6 6.3 9.2 9.2 15.6 8.8 7.7 16.5 90.5 94.7 76.4 113.2 99.9 80.1 110.9 85.1 112.6 76.0 101.9 116.2 28.6 32.1 25.4 9.8 23.2 10.1 10.3 19.1 25.6 27.2 19.6 17.8 56.4 18.6 20.0 29.5 25.0 29.8 19.4 41.0 19.6 22.5 7.3 21.5 32.8 26.6 16.7 27.3 28.4 19.9 27.1 25.1 49.5 27.8 29.2 30.8 29.6 19.9 28.8 90.9 26.7 31.8 24.4 21.0 11.3 9.3 44.7 21.2 16.0 8.4 27.3 14.9 23.7 12.1 29.7 26.6 33.6 51.9 24.7 9.6 34.2 19.6 19.4 45.5 19.7 28.3 30.0 40.6 38.5 29.0 11.8 25.2 20.0 33.9 24.9 10.7 DDC AADC ENSG00000132437 "Dopa decarboxylase" P20711 7 50458436-50565405 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Catecholamine biosynthesis" "Decarboxylase, Lyase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 165.8;kidney: 314.9;retina: 175.6" "Group enriched" "Detected in many" 4 "Enteroendocrine cells: 410.3;Proximal enterocytes: 391.5;Proximal tubular cells: 429.5;Rod photoreceptor cells: 498.9" "Group enriched" "Detected in many" 5 "colorectal cancer: 23.5;liver cancer: 13.4;pancreatic cancer: 6.4;renal cancer: 18.7;stomach cancer: 9.9" "Group enriched" "Detected in many" 9 "midbrain: 86.3;pons: 29.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "CACO-2: 54.5;Hep G2: 49.3;OE19: 83.6;SCLC-21H: 130.9;SH-SY5Y: 135.9" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "midbrain: 74.5;pons: 29.4" HPA017742 Enhanced Approved "Actin filaments" NA NA 120000 "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Actin filaments" "HPA017742: AB_1847832" "unprognostic (1.04e-1)" "unprognostic (3.68e-2)" "unprognostic (2.57e-2)" "unprognostic (3.49e-5)" "unprognostic (1.17e-1)" "unprognostic (1.03e-1)" "unprognostic (1.28e-1)" "unprognostic (5.15e-2)" "unprognostic (4.69e-2)" "unprognostic (5.44e-2)" "unprognostic (9.36e-3)" "unprognostic (5.24e-2)" "unprognostic (1.76e-3)" "unprognostic (1.60e-1)" "unprognostic (3.55e-1)" "unprognostic (7.65e-2)" "unprognostic (1.16e-1)" 0.5 48.9 0.1 2.3 0.7 0.0 1.0 0.0 0.6 0.0 0.2 36.5 154.8 0.0 9.1 0.1 0.0 0.1 0.0 0.2 2.2 314.9 54.6 2.0 0.1 6.1 86.3 0.8 15.8 0.0 0.0 0.0 29.4 0.6 37.5 175.6 0.0 0.0 0.0 0.1 165.8 1.7 0.0 0.1 18.1 1.5 1.9 0.0 0.2 0.0 0.0 0.0 0.1 0.2 0.0 1.7 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 54.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 49.3 0.0 0.0 11.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.1 83.6 0.0 0.0 0.0 0.7 1.3 0.0 130.9 135.9 0.0 4.4 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.7 0.0 0.6 0.2 2.2 6.1 86.3 29.4 0.0 1.9 0.2 0.0 0.0 12.2 0.0 2.5 0.0 0.0 0.0 0.0 89.3 0.1 0.1 0.4 2.8 0.6 3.7 41.7 0.0 0.0 34.4 25.4 0.1 6.6 0.1 0.0 1.8 410.3 0.0 0.3 0.9 0.1 0.1 0.0 0.4 0.0 0.0 1.1 67.2 0.1 3.3 0.4 67.8 0.0 1.3 0.0 5.4 0.0 2.5 0.0 0.0 0.0 45.1 0.0 0.0 0.1 0.2 31.8 0.0 0.0 0.3 391.5 429.5 0.0 498.9 0.0 0.0 0.0 4.0 0.4 0.0 0.0 0.1 1.3 0.1 88.7 0.2 DDHD1 "KIAA1705, PA-PLA1, SPG28" ENSG00000100523 "DDHD domain containing 1" Q8NEL9 14 53036745-53153323 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Lipid degradation, Lipid metabolism" Hydrolase "Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 30.7" "Cell type enhanced" "Detected in many" "Early spermatids: 280.9;Excitatory neurons: 140.5;Late spermatids: 146.3;Oligodendrocytes: 177.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049870 Enhanced NA NA "Cluster 15: NK-cells - Transcription" "Cluster 21: Non-specific - Transcription" "Cluster 12: NES - Nervous system development" "Cluster 23: Spermatids - Flagellum & Golgi organization" "HPA049870: AB_2680925" "unprognostic (2.48e-1)" "unprognostic (1.49e-2)" "unprognostic (1.39e-1)" "unprognostic (1.79e-1)" "unprognostic (8.14e-3)" "unprognostic (9.40e-2)" "unprognostic (4.91e-3)" "unprognostic (2.25e-2)" "unprognostic (8.07e-2)" "unprognostic (2.63e-1)" "unprognostic (3.24e-3)" "unprognostic (1.78e-1)" "unprognostic (4.67e-6)" "unprognostic (1.61e-1)" "unprognostic (1.92e-1)" "unprognostic (2.28e-1)" "unprognostic (1.11e-1)" 4.5 3.6 5.7 6.0 6.6 8.7 3.9 9.7 10.1 5.3 0.8 3.8 2.5 5.0 2.2 2.5 3.7 4.6 5.1 6.8 6.9 2.3 2.6 5.2 10.0 6.9 6.6 5.1 2.9 4.4 5.3 7.5 7.6 3.7 4.6 16.7 2.3 4.1 3.1 3.3 4.7 5.1 4.2 6.2 3.8 30.7 6.6 6.6 3.5 5.3 8.5 5.4 3.4 10.3 8.7 10.2 32.5 12.7 14.0 12.7 6.7 13.0 9.8 9.4 10.3 2.4 1.7 23.3 6.4 9.1 8.7 3.7 15.8 3.6 11.3 12.8 7.0 3.0 8.7 4.7 12.1 10.6 10.3 6.9 4.3 10.0 8.4 6.7 7.1 7.9 5.9 19.6 11.0 9.2 12.6 5.4 6.7 5.6 8.4 9.6 34.0 4.0 5.0 11.3 14.5 9.3 15.2 4.2 4.4 5.7 5.9 6.9 10.5 8.9 13.9 13.4 9.6 9.1 6.3 15.3 4.7 9.6 5.0 1.6 1.4 1.2 4.6 2.2 4.4 3.2 3.7 5.1 1.7 2.6 3.2 3.9 0.8 4.6 3.7 1.5 5.3 1.3 5.7 6.6 9.7 10.1 6.8 6.9 6.9 6.6 7.6 4.2 6.6 10.3 12.0 6.4 15.4 69.9 40.4 6.1 7.1 3.5 23.9 64.2 9.3 7.0 13.2 7.2 3.6 9.2 87.6 17.6 46.5 3.2 0.0 6.8 280.9 8.7 38.7 19.1 8.4 27.8 140.5 6.7 7.4 25.4 7.7 15.3 7.6 20.0 5.3 5.8 16.2 45.4 120.6 5.0 2.0 18.5 13.3 146.3 13.7 31.5 5.4 38.4 22.1 19.1 49.4 104.0 177.9 5.1 3.4 20.7 42.7 8.2 1.9 4.9 6.7 35.0 19.7 17.1 15.8 57.4 46.6 9.7 6.0 17.4 42.4 24.9 5.6 5.9 DDHD2 "KIAA0725, SAMWD1, SPG54" ENSG00000085788 "DDHD domain containing 2" O94830 8 38225218-38275558 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Lipid degradation, Lipid metabolism" Hydrolase "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB015202, HPA023143, HPA023147" Supported Supported "Centriolar satellite,Cytosol" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 1: K-562 - Erythropoiesis" "Cluster 52: Non-specific - Transcription" Cytosol "Centriolar satellite" "CAB015202: , HPA023143: AB_1847534, HPA023147: AB_1847535" "unprognostic (1.49e-3)" "unprognostic (2.40e-1)" "unprognostic (1.40e-1)" "unprognostic (1.04e-1)" "unprognostic (2.64e-1)" "prognostic favorable (7.72e-4)" "unprognostic (4.54e-2)" "unprognostic (1.79e-2)" "unprognostic (1.87e-1)" "unprognostic (2.63e-2)" "unprognostic (1.04e-1)" "unprognostic (4.49e-2)" "unprognostic (3.01e-3)" "unprognostic (3.21e-2)" "unprognostic (2.46e-1)" "unprognostic (7.88e-2)" "unprognostic (1.49e-1)" 28.9 18.1 27.3 14.4 32.1 14.9 19.4 33.8 39.7 22.0 23.5 20.1 19.6 20.9 23.3 20.9 19.1 17.5 27.7 30.1 29.3 21.6 12.1 16.9 19.8 32.1 27.7 28.9 22.2 21.1 18.3 15.2 35.1 22.6 16.7 31.7 18.3 29.3 32.0 16.8 22.2 18.2 30.7 17.2 15.0 22.7 32.4 19.5 18.7 35.8 22.3 17.6 17.7 38.8 57.7 26.1 58.3 28.3 21.8 30.6 18.4 18.1 33.0 42.5 38.4 30.8 22.6 22.8 24.1 32.8 26.3 22.7 33.9 34.1 64.9 19.8 22.6 83.0 36.0 29.9 19.6 9.6 12.8 16.0 26.4 26.4 26.8 27.0 51.5 31.2 59.6 24.5 27.3 12.3 66.6 14.7 13.2 9.5 15.1 34.0 50.1 16.5 22.5 34.8 21.2 32.0 44.4 21.9 22.2 18.2 26.3 26.1 46.6 24.8 31.1 24.3 28.4 25.7 25.8 54.0 39.5 18.4 35.3 2.5 3.9 4.7 10.6 4.9 11.8 9.8 9.6 11.9 6.5 15.2 10.2 7.5 0.3 16.5 3.5 3.8 15.6 7.3 27.3 32.1 33.8 39.7 30.1 29.3 32.1 27.7 35.1 30.7 32.4 38.8 15.4 22.4 7.0 20.5 17.3 13.8 10.6 8.2 14.2 27.9 12.7 7.4 23.9 8.6 8.4 20.2 18.8 12.1 16.2 7.2 23.5 11.6 4.5 9.7 13.4 13.8 15.7 25.2 51.3 11.0 11.5 13.6 12.8 12.4 21.0 22.8 12.5 5.5 7.4 53.8 51.2 9.3 6.1 8.4 11.2 10.8 20.2 7.7 19.6 21.5 13.0 19.9 16.5 35.7 46.9 16.2 6.2 20.7 24.0 10.2 23.8 10.0 5.4 5.9 6.6 17.6 13.6 30.9 35.3 8.7 10.7 6.4 17.9 13.4 8.9 7.7 DENND5A "FLJ22354, FLJ33829, FLJ43455, KIAA1091, RAB6IP1" ENSG00000184014 "DENN domain containing 5A" Q6IQ26 11 9138825-9265959 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Guanine-nucleotide releasing factor" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Oligodendrocyte precursor cells: 136.2;Oligodendrocytes: 287.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA052923, HPA055009" Uncertain Approved "Golgi apparatus,Vesicles" NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 57: Non-specific - Angiogenesis" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 44: Endometrium - Transcription" "Golgi apparatus, Vesicles" "HPA052923: AB_2681989, HPA055009: AB_2682669" "unprognostic (5.28e-3)" "unprognostic (1.42e-1)" "unprognostic (1.17e-1)" "unprognostic (1.28e-2)" "unprognostic (4.03e-1)" "unprognostic (3.48e-1)" "prognostic unfavorable (5.05e-6)" "unprognostic (1.84e-1)" "unprognostic (2.96e-1)" "unprognostic (1.02e-1)" "unprognostic (5.15e-2)" "unprognostic (3.10e-1)" "prognostic unfavorable (1.14e-6)" "unprognostic (9.86e-3)" "unprognostic (1.03e-1)" "unprognostic (4.32e-1)" "unprognostic (1.40e-2)" 45.8 23.5 72.4 23.2 90.5 21.7 36.3 85.0 80.7 36.1 45.5 44.2 5.8 38.5 14.1 17.4 37.5 23.3 58.0 65.1 85.4 25.5 15.7 46.1 16.8 81.5 86.6 30.2 23.2 18.5 20.5 28.8 77.0 24.5 12.9 34.7 19.5 40.0 26.7 17.3 20.2 47.5 74.9 31.4 23.7 15.8 87.3 28.0 22.0 33.7 15.9 40.4 25.1 81.3 18.8 23.3 63.7 56.1 113.0 92.0 61.7 69.2 99.8 85.7 104.5 16.4 13.6 0.0 30.5 129.0 82.4 12.7 64.3 22.5 111.4 73.0 30.9 6.2 32.2 34.5 61.0 34.4 13.9 76.8 11.5 51.1 74.6 59.7 83.8 21.9 33.6 0.3 101.9 11.0 19.4 15.1 19.7 3.2 28.6 34.2 46.1 0.3 41.6 13.4 15.9 32.1 65.8 29.7 27.2 70.4 15.7 24.6 59.2 63.0 41.0 78.7 47.3 1.4 0.4 18.7 63.4 14.1 51.9 4.4 5.0 5.7 0.1 6.3 0.6 1.8 1.3 1.3 4.6 0.2 3.8 1.9 10.8 1.0 9.2 1.1 0.0 1.9 72.4 90.5 85.0 80.7 65.1 85.4 81.5 86.6 77.0 74.9 87.3 81.3 34.1 19.2 14.5 43.8 7.4 21.7 19.3 10.3 10.2 9.7 15.3 13.8 33.2 14.3 8.0 14.7 60.5 15.9 6.4 0.3 0.0 7.3 1.1 26.3 31.8 31.3 6.6 7.8 47.7 6.7 20.1 27.1 3.1 57.8 2.5 11.6 21.4 10.9 21.8 13.5 74.2 2.2 4.1 36.3 63.4 2.0 21.5 48.9 19.6 68.4 41.1 11.6 3.1 136.2 287.1 8.4 1.4 20.7 0.9 32.5 0.1 10.3 4.8 10.5 26.3 34.4 31.6 7.9 12.3 6.3 8.2 11.2 6.3 16.0 0.8 15.0 DEPDC5 "DEP.5, KIAA0645" ENSG00000100150 "DEP domain containing 5, GATOR1 subcomplex subunit" O75140 22 31753867-31908033 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "GTPase activation" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 31.9;Inhibitory neurons: 29.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 34.8" "Lineage enriched" "Detected in all" 5 "granulocytes: 34.8" "Cell line enhanced" "Detected in all" "U-698: 31.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA054969, HPA055619" Uncertain NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 35: Non-specific - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 52: Non-specific - Transcription" "HPA054969: AB_2682655, HPA055619: AB_2682864" "unprognostic (5.68e-2)" "unprognostic (1.16e-2)" "unprognostic (8.98e-3)" "unprognostic (8.83e-2)" "unprognostic (5.60e-2)" "unprognostic (7.87e-3)" "unprognostic (5.93e-2)" "unprognostic (1.12e-2)" "unprognostic (2.95e-1)" "unprognostic (1.78e-1)" "unprognostic (4.59e-3)" "unprognostic (6.64e-2)" "prognostic favorable (2.46e-5)" "unprognostic (5.66e-2)" "unprognostic (7.88e-2)" "unprognostic (1.26e-1)" "prognostic favorable (4.86e-5)" 6.3 7.7 6.4 5.1 6.5 4.4 5.6 8.7 10.8 8.7 5.8 7.4 3.0 6.0 3.4 7.2 6.6 3.5 4.8 6.5 6.3 5.5 9.9 5.3 6.3 6.0 5.8 11.3 4.2 4.9 6.2 3.6 6.2 5.5 5.2 4.0 6.0 3.0 5.9 6.4 8.5 3.7 5.3 9.4 6.2 7.4 6.5 4.9 5.7 3.8 9.7 6.6 7.1 8.6 5.7 5.0 9.1 5.7 4.5 4.7 7.4 3.9 6.4 5.1 6.8 6.8 3.4 13.0 1.5 5.5 4.1 5.8 6.3 6.3 9.1 6.7 5.8 6.1 6.1 6.7 4.4 20.6 19.0 5.2 3.2 9.6 4.8 4.3 9.3 4.8 4.3 3.9 7.3 5.5 5.8 5.8 4.6 9.9 2.1 11.2 10.0 7.4 6.0 12.0 6.0 6.7 7.8 4.2 5.2 6.6 4.4 11.5 8.0 5.0 6.0 5.2 3.8 5.8 5.7 31.5 5.5 6.0 5.1 34.8 2.9 15.2 2.6 3.4 3.0 6.8 1.9 1.5 2.5 4.2 3.0 3.8 1.8 4.2 3.7 1.8 2.3 1.3 6.4 6.5 8.7 10.8 6.5 6.3 6.0 5.8 6.2 5.3 6.5 8.6 4.7 0.0 3.9 20.5 12.0 2.7 1.8 3.0 5.2 4.9 4.5 2.9 4.3 2.8 5.5 7.3 2.1 3.8 4.5 10.4 3.9 5.1 1.3 4.2 6.1 5.1 13.2 2.1 31.9 4.9 3.1 4.3 6.6 6.5 5.7 18.2 4.2 4.9 3.5 16.8 29.6 6.2 6.1 3.1 2.2 2.2 1.8 6.9 3.6 24.4 3.9 4.2 5.2 23.1 24.3 4.7 5.6 2.6 4.4 1.6 4.7 2.8 5.2 5.6 6.6 3.1 3.1 4.8 5.2 4.3 2.3 2.3 5.3 11.4 5.0 1.8 DHDDS "DS, FLJ13102, hCIT, HDS, RP59" ENSG00000117682 "Dehydrodolichyl diphosphate synthase subunit" Q86SQ9 1 26432282-26471306 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Lipid metabolism" Transferase "Disease variant, Epilepsy, Mental retardation, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 256.5;Early spermatids: 99.1;Rod photoreceptor cells: 106.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026721, HPA026727" Uncertain Uncertain "Plasma membrane" NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 9: Photoreceptor cells - Phototransduction" "Plasma membrane" "HPA026721: AB_1847643, HPA026727: AB_1847644" "unprognostic (1.11e-2)" "unprognostic (5.43e-2)" "unprognostic (5.12e-2)" "unprognostic (9.81e-2)" "unprognostic (6.71e-2)" "unprognostic (7.23e-2)" "unprognostic (1.32e-3)" "unprognostic (3.81e-3)" "unprognostic (2.40e-1)" "unprognostic (5.42e-2)" "unprognostic (4.51e-2)" "unprognostic (3.40e-2)" "prognostic favorable (4.08e-7)" "unprognostic (9.42e-2)" "unprognostic (2.85e-1)" "unprognostic (2.22e-1)" "unprognostic (2.95e-1)" 57.3 19.6 12.3 18.9 11.8 12.4 22.7 32.5 14.0 14.6 14.6 37.3 19.1 13.5 38.5 26.3 12.9 15.9 19.8 12.8 13.3 25.5 22.0 13.9 17.6 15.5 16.9 11.4 18.5 39.8 20.9 12.6 18.8 14.1 38.8 37.8 43.3 14.0 13.5 21.2 18.2 18.4 9.0 14.1 23.3 12.3 14.1 14.1 19.1 11.8 20.8 18.1 14.4 12.2 34.2 24.8 20.6 23.8 36.1 28.2 28.4 54.9 33.4 44.0 41.6 37.4 34.6 38.4 33.3 57.2 30.0 24.1 25.4 42.8 42.9 22.7 13.9 38.0 66.9 30.8 39.3 41.4 51.5 40.3 27.6 59.1 32.2 29.4 51.2 26.7 27.3 41.0 39.7 19.4 23.1 20.2 26.3 53.1 36.2 25.3 33.4 31.2 25.4 28.8 24.4 19.4 36.4 38.0 26.6 26.8 29.8 20.9 63.0 30.1 26.3 60.4 32.0 48.1 72.4 39.5 43.0 54.0 26.8 9.4 16.1 9.6 13.8 23.6 9.8 13.2 9.0 9.1 13.6 10.2 7.4 10.9 13.0 10.1 23.1 11.5 8.3 10.5 12.3 11.8 32.5 14.0 12.8 13.3 15.5 16.9 18.8 9.0 14.1 12.2 9.4 9.6 7.8 7.8 13.5 4.6 9.6 12.0 10.8 29.6 9.6 7.4 15.5 15.7 13.8 14.7 256.5 18.3 13.7 76.3 11.7 19.3 99.1 11.6 12.9 11.1 20.9 5.7 26.9 14.5 23.4 11.1 33.6 20.0 19.0 14.4 10.0 13.2 24.5 15.2 28.5 46.3 14.2 11.5 7.1 23.4 10.5 10.5 10.6 10.3 34.4 16.3 14.4 9.0 11.4 17.6 40.3 7.5 18.7 10.6 24.7 29.3 11.5 106.1 0.0 8.4 14.5 13.2 13.5 12.4 5.1 25.4 10.3 15.8 26.0 12.2 DHTKD1 "CMT2Q, DKFZP762M115, KIAA1630, MGC3090" ENSG00000181192 "Dehydrogenase E1 and transketolase domain containing 1" Q96HY7 10 12068954-12123221 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Glycolysis Oxidoreductase "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 129.5" "Cell type enhanced" "Detected in all" "Hepatocytes: 227.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "T-47d: 102.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037949, HPA037950, HPA066098" Enhanced Supported Mitochondria NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 6: T47d - Mammary gland" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "HPA037949: AB_2675752, HPA037950: AB_10673650, HPA066098: AB_2685617" "unprognostic (3.76e-2)" "unprognostic (8.08e-3)" "unprognostic (2.24e-1)" "unprognostic (1.15e-1)" "unprognostic (1.34e-1)" "unprognostic (3.04e-3)" "unprognostic (3.83e-3)" "unprognostic (5.01e-2)" "unprognostic (5.34e-2)" "unprognostic (3.02e-3)" "unprognostic (3.46e-1)" "unprognostic (1.56e-1)" "prognostic favorable (3.43e-4)" "unprognostic (2.12e-1)" "unprognostic (1.31e-1)" "unprognostic (1.74e-2)" "unprognostic (2.88e-3)" 10.7 8.4 8.1 6.8 10.4 3.8 8.4 12.6 8.5 8.8 11.9 10.1 7.6 6.2 6.8 7.5 6.1 5.3 13.2 7.6 8.5 42.7 129.5 5.4 8.5 9.5 8.6 10.0 18.0 12.7 5.6 7.7 9.5 12.9 10.8 7.5 13.1 5.7 18.7 5.6 6.9 5.7 8.8 7.8 10.9 4.7 9.1 10.5 11.6 23.1 9.7 6.3 6.1 11.4 27.0 20.4 29.8 23.8 18.2 10.8 35.9 13.3 8.6 23.4 20.6 13.1 15.7 19.3 4.3 8.4 10.8 37.4 31.6 10.4 26.6 10.9 14.2 10.6 7.7 10.1 17.8 4.2 3.8 13.3 7.9 13.7 5.5 9.2 13.0 23.1 16.7 15.1 6.3 52.3 14.4 7.7 16.7 24.9 4.7 24.3 9.7 16.5 15.2 6.4 7.7 34.9 26.3 46.3 15.4 31.7 102.2 15.2 5.8 7.5 5.4 15.8 9.9 13.4 10.3 12.6 9.7 7.4 12.8 23.8 6.8 15.4 4.2 9.2 4.5 13.0 3.2 2.7 11.9 9.9 3.1 4.1 19.4 14.3 17.0 17.3 5.7 4.9 8.1 10.4 12.6 8.5 7.6 8.5 9.5 8.6 9.5 8.8 9.1 11.4 6.9 12.8 38.8 21.5 21.3 5.2 6.7 5.3 10.2 13.3 13.7 8.3 31.1 28.6 7.8 16.5 10.4 35.4 23.2 14.6 19.6 10.9 3.5 8.8 17.3 8.1 11.3 21.9 12.8 11.1 25.1 8.1 21.9 20.8 8.8 45.2 11.0 227.4 10.3 26.9 17.3 18.0 4.1 15.3 10.1 4.2 12.5 13.5 5.4 17.8 13.4 10.4 8.2 15.6 20.5 12.4 9.6 12.0 22.6 9.6 9.4 62.5 5.2 19.2 13.1 10.6 7.4 6.7 3.8 16.2 6.0 13.5 8.4 21.8 16.6 7.8 DHX38 "DDX38, hPrp16, KIAA0224, PRP16, PRPF16" ENSG00000140829 "DEAH-box helicase 38" Q92620 16 72093613-72112912 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "mRNA processing, mRNA splicing" "Helicase, Hydrolase" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041347, HPA041604" Uncertain Supported Nucleoplasm NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" Nucleoplasm "HPA041347: AB_10796571, HPA041604: AB_2677577" "unprognostic (2.38e-1)" "unprognostic (1.89e-1)" "unprognostic (1.24e-2)" "unprognostic (3.25e-2)" "unprognostic (1.07e-1)" "unprognostic (1.01e-1)" "unprognostic (6.32e-3)" "unprognostic (8.50e-3)" "unprognostic (6.97e-2)" "unprognostic (1.45e-1)" "unprognostic (7.92e-2)" "unprognostic (1.28e-3)" "unprognostic (4.20e-3)" "unprognostic (2.68e-1)" "unprognostic (9.46e-2)" "unprognostic (2.40e-1)" "unprognostic (2.40e-2)" 25.8 18.7 22.4 22.8 24.4 39.7 23.8 22.2 24.7 25.1 25.9 24.8 19.6 25.5 10.7 24.2 23.8 15.0 27.0 21.5 21.6 19.6 24.0 23.9 27.8 23.2 23.2 30.6 20.2 22.9 19.3 18.6 22.5 20.9 16.1 13.2 21.1 14.4 39.9 27.6 27.3 17.6 22.2 30.4 22.5 21.3 23.5 24.2 22.8 21.4 23.1 23.7 22.9 25.0 38.5 55.0 39.4 21.9 33.4 25.8 51.1 33.6 32.6 49.1 37.8 66.4 37.5 50.5 29.2 50.9 27.0 48.6 46.3 45.8 38.0 25.3 50.0 38.7 48.9 92.5 30.8 46.9 66.7 35.6 41.2 66.1 47.4 25.9 42.9 35.7 58.9 22.9 30.6 112.8 43.9 53.1 49.7 23.9 30.9 55.8 27.1 49.9 24.0 35.6 35.6 38.9 43.8 20.3 24.5 22.5 36.8 38.4 49.4 46.6 40.8 34.8 37.3 56.2 47.6 96.7 43.9 32.1 37.5 7.1 6.2 7.1 11.3 8.3 9.8 8.1 6.8 8.2 6.2 6.0 7.4 7.9 6.4 8.8 5.1 5.5 8.6 5.5 22.4 24.4 22.2 24.7 21.5 21.6 23.2 23.2 22.5 22.2 23.5 25.0 22.5 25.6 34.3 13.7 24.4 12.2 11.0 9.5 20.5 30.7 12.0 13.6 8.6 20.0 22.0 14.7 16.7 15.0 33.3 28.5 0.0 14.5 9.0 19.3 23.0 22.3 30.5 16.8 6.7 20.6 14.3 17.1 28.1 23.6 43.0 24.0 15.0 13.6 14.9 30.3 6.1 24.8 6.1 15.2 13.9 11.0 28.9 20.3 8.8 5.6 16.9 17.9 19.6 8.0 11.1 23.7 17.1 25.2 22.4 12.7 21.1 8.6 19.0 35.3 19.7 25.6 19.1 25.5 17.8 18.5 12.8 20.4 28.2 20.6 23.4 12.6 DIABLO "DFNA64, DIABLO-S, FLJ10537, FLJ25049, SMAC" ENSG00000184047 "Diablo IAP-binding mitochondrial protein" Q9NR28 12 122207663-122227456 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" Apoptosis "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 31.3;Plasma cells: 29.2;Squamous epithelial cells: 30.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001825, CAB003857, CAB016688" Supported Enhanced Mitochondria NA Yes "Cluster 12: Non-specific - Basic cellular processes" "Cluster 43: Testis - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" Mitochondria "CAB003857: AB_365498, CAB016688: AB_1615783, HPA001825: AB_1857247" "unprognostic (3.67e-2)" "unprognostic (1.90e-1)" "unprognostic (1.11e-1)" "unprognostic (3.10e-3)" "unprognostic (1.64e-1)" "unprognostic (2.38e-3)" "unprognostic (1.40e-3)" "unprognostic (5.06e-2)" "unprognostic (1.48e-1)" "unprognostic (1.03e-1)" "unprognostic (1.33e-2)" "unprognostic (4.05e-2)" "prognostic unfavorable (5.35e-4)" "unprognostic (6.68e-2)" "unprognostic (2.36e-1)" "unprognostic (2.00e-1)" "unprognostic (1.40e-1)" 23.8 34.3 29.8 17.3 30.8 32.5 25.3 33.7 36.8 21.4 30.4 28.7 21.7 27.0 36.1 30.8 23.3 18.0 30.3 28.7 32.0 34.5 39.6 21.2 21.0 32.0 31.4 27.8 27.7 32.2 41.4 25.8 32.1 21.9 24.5 27.5 28.9 19.5 37.4 25.4 26.9 20.5 33.6 24.3 26.6 53.2 31.0 26.9 25.8 34.5 24.9 32.0 24.5 33.4 49.0 94.7 65.4 44.7 45.9 44.6 50.2 49.5 48.3 56.9 50.8 82.4 24.9 59.2 45.4 45.2 42.4 47.4 72.2 59.3 67.0 51.1 56.4 65.2 36.6 76.7 65.3 71.0 25.9 62.2 41.3 67.3 100.1 64.4 66.8 57.9 75.9 24.5 56.1 72.4 58.6 103.8 52.9 69.5 88.0 52.3 65.2 65.4 64.4 74.7 61.7 62.6 66.1 26.2 54.8 73.3 87.9 49.2 46.0 43.7 53.6 50.0 45.4 52.8 95.5 84.3 55.8 53.6 58.8 43.3 39.8 39.8 39.9 41.4 37.8 46.3 36.4 37.2 48.3 36.4 35.6 36.1 17.9 45.5 40.1 37.5 46.3 42.0 29.8 30.8 33.7 36.8 28.7 32.0 32.0 31.4 32.1 33.6 31.0 33.4 0.2 0.0 0.6 7.2 19.7 5.0 5.9 7.6 31.3 7.3 0.0 0.0 1.3 10.0 3.3 0.0 4.2 11.3 3.0 8.2 0.0 0.2 6.3 0.0 0.0 3.8 7.3 20.4 14.5 0.0 10.8 7.7 25.5 0.0 4.5 0.0 5.3 2.9 6.5 3.3 14.1 8.8 8.2 3.3 3.6 4.6 5.6 7.1 3.6 3.7 2.7 7.6 9.2 9.0 15.1 0.2 11.9 3.4 29.2 3.9 16.8 0.1 1.7 11.1 6.6 2.6 4.9 19.2 16.3 30.4 4.8 13.4 13.2 0.0 9.9 3.9 DIAPH1 "DFNA1, hDIA1, LFHL1" ENSG00000131504 "Diaphanous related formin 1" O60610 5 141515016-141619055 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" Hearing Actin-binding "Cancer-related genes, Deafness, Disease variant, Epilepsy, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 172.0" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HMC-1: 564.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004916, HPA076913" Approved Uncertain "Plasma membrane,Cytosol" NA NA 2000000 "Cluster 41: Basophils - Cellular respiration" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 3: HMC-1 - Innate immune response" "Cluster 63: NK-cells & T-cells - Immune response" "Plasma membrane, Cytosol" "HPA004916: AB_1847668, HPA076913: " "unprognostic (6.79e-2)" "unprognostic (2.99e-1)" "unprognostic (2.12e-3)" "unprognostic (3.73e-2)" "unprognostic (4.18e-2)" "unprognostic (1.54e-1)" "unprognostic (2.08e-1)" "unprognostic (4.54e-3)" "unprognostic (2.03e-1)" "unprognostic (1.27e-2)" "prognostic unfavorable (7.81e-5)" "unprognostic (2.88e-3)" "prognostic favorable (1.29e-5)" "unprognostic (1.64e-2)" "unprognostic (1.84e-2)" "unprognostic (7.00e-2)" "unprognostic (1.65e-1)" 27.9 20.3 21.0 42.1 22.5 90.2 24.2 18.3 20.9 24.4 40.0 31.0 40.6 18.5 44.3 58.0 25.2 30.0 34.9 21.5 25.7 38.1 91.7 51.3 67.0 18.8 19.9 12.9 37.3 44.6 24.5 25.1 20.1 14.7 31.1 28.4 36.1 19.3 172.0 47.3 36.5 18.7 18.0 36.3 45.1 19.9 27.4 68.5 33.1 55.7 66.4 47.1 30.4 18.6 147.8 92.6 53.2 68.4 40.4 54.5 71.3 59.5 62.2 67.7 70.2 318.1 131.6 156.5 88.1 85.5 103.0 157.9 116.9 191.5 84.8 88.9 66.6 282.6 121.4 103.6 37.7 198.9 564.7 34.4 102.1 94.5 95.5 30.5 87.0 234.8 101.2 106.9 67.7 141.5 217.2 256.8 51.6 75.2 61.6 240.1 87.1 87.6 129.8 158.5 69.4 37.3 146.2 184.6 59.5 47.5 77.5 92.1 52.8 93.9 49.9 52.1 119.9 54.2 94.4 111.7 50.2 153.7 57.8 23.6 12.8 29.8 32.6 14.0 21.2 9.3 20.3 25.3 12.6 9.1 14.8 23.9 13.7 13.7 15.1 10.0 18.7 15.4 21.0 22.5 18.3 20.9 21.5 25.7 18.8 19.9 20.1 18.0 27.4 18.6 33.9 48.1 46.8 11.8 40.0 52.6 60.8 22.4 21.6 17.3 35.1 23.1 18.6 22.8 48.0 44.1 54.2 20.9 96.9 60.5 5.9 62.7 27.9 42.3 18.9 39.0 5.4 52.6 44.1 98.0 31.9 25.9 76.0 83.0 46.9 14.5 16.8 91.6 17.1 6.7 33.6 23.1 12.2 38.4 60.6 9.0 11.8 78.5 19.6 24.4 54.6 12.1 115.4 25.6 9.1 122.9 35.7 10.9 54.1 77.3 35.2 13.9 30.4 69.0 13.1 15.4 26.4 18.3 26.1 38.7 59.7 52.1 92.8 18.3 30.1 91.2 DIAPH3 "AN, AUNA1, DRF3, FLJ34705, NSDAN" ENSG00000139734 "Diaphanous related formin 3" Q9NSV4 13 59665583-60163928 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cancer-related genes, Deafness, Neuropathy, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 7.1;testis: 18.9" "Cell type enriched" "Detected in many" 5 "Early spermatids: 414.4" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA032151 Supported "Plasma membrane,Microtubules" NA Yes "Cluster 23: Testis - Cell cycle regulation" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 29: Early spermatids - Spermatogenesis" "Plasma membrane, Microtubules" "HPA032151: AB_2674181" "unprognostic (3.78e-2)" "unprognostic (1.28e-2)" "prognostic favorable (9.04e-4)" "prognostic unfavorable (4.18e-4)" "unprognostic (2.78e-1)" "unprognostic (4.69e-2)" "unprognostic (1.27e-4)" "prognostic unfavorable (3.72e-4)" "unprognostic (1.74e-2)" "unprognostic (2.19e-1)" "unprognostic (5.22e-5)" "unprognostic (3.59e-3)" "unprognostic (5.31e-5)" "unprognostic (4.30e-2)" "unprognostic (2.37e-1)" "unprognostic (4.07e-1)" "unprognostic (2.74e-3)" 0.4 0.1 0.1 1.7 0.2 7.1 0.8 0.3 0.3 0.3 0.2 1.9 1.9 0.6 0.0 2.1 0.1 0.4 0.1 0.1 0.2 0.8 0.2 1.2 2.4 0.2 0.3 0.1 0.2 0.1 0.0 3.5 0.2 0.1 2.1 0.0 0.5 0.0 0.0 1.3 1.6 2.6 0.1 0.5 1.6 18.9 0.3 5.4 0.1 0.0 2.4 0.6 0.7 0.2 47.7 15.6 15.8 9.1 2.7 7.1 26.9 65.0 28.7 64.2 55.6 41.7 31.4 15.9 5.2 33.4 16.7 31.7 26.0 25.5 96.9 18.0 17.9 22.7 37.6 9.5 4.1 31.2 17.4 2.8 0.6 39.2 26.3 16.3 29.2 14.0 17.8 21.9 61.8 6.9 28.0 10.2 14.7 22.5 8.9 18.8 38.9 12.9 19.9 9.6 8.3 14.3 33.2 22.8 9.5 33.8 16.7 16.8 29.3 40.5 25.9 13.7 54.5 14.7 17.1 24.4 10.9 15.2 31.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.2 0.3 0.3 0.1 0.2 0.2 0.3 0.2 0.1 0.3 0.2 0.6 54.5 3.4 39.8 1.9 3.7 0.8 2.1 2.8 0.0 3.9 1.5 1.0 2.8 1.8 0.0 0.0 21.1 1.1 3.8 5.9 1.3 414.4 2.5 3.5 2.1 0.0 26.7 5.6 4.0 30.7 5.8 9.7 9.3 0.0 78.8 1.8 0.4 6.1 0.0 3.3 2.6 2.0 1.0 1.2 56.0 0.6 1.5 0.0 5.6 0.1 3.5 2.1 19.1 1.8 1.5 0.2 0.0 18.9 0.4 1.1 5.4 0.2 0.0 0.0 0.0 7.9 39.2 17.8 11.6 1.1 7.3 2.2 2.8 5.6 1.5 DMXL2 "DFNA71, KIAA0856, RC3" ENSG00000104093 "Dmx like 2" Q8TDJ6 15 51447711-51622833 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Deafness, Diabetes mellitus, Disease variant, Epilepsy, Hypogonadotropic hypogonadism, Neuropathy, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 138.9;Inhibitory neurons: 122.9;Kupffer cells: 96.1;Macrophages: 106.3;monocytes: 84.9;Oligodendrocyte precursor cells: 96.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 4 "classical monocyte: 2.8;intermediate monocyte: 2.2;neutrophil: 2.2;non-classical monocyte: 2.7" "Group enriched" "Detected in many" 4 "granulocytes: 2.2;monocytes: 2.8" "Cell line enhanced" "Detected in many" "U-937: 44.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039375 Approved NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 32: U-937 - Innate immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "HPA039375: AB_10673610" "unprognostic (5.66e-2)" "unprognostic (9.67e-2)" "unprognostic (1.40e-2)" "unprognostic (2.21e-1)" "unprognostic (1.74e-1)" "unprognostic (1.60e-1)" "unprognostic (1.05e-2)" "unprognostic (8.38e-2)" "unprognostic (3.39e-1)" "unprognostic (2.32e-1)" "unprognostic (3.67e-3)" "unprognostic (1.24e-1)" "prognostic unfavorable (7.50e-4)" "unprognostic (1.09e-1)" "unprognostic (1.67e-1)" "unprognostic (8.60e-3)" "unprognostic (2.70e-2)" 5.3 4.7 4.1 11.1 4.7 17.1 3.4 4.0 7.3 4.6 8.1 6.5 9.2 4.4 13.9 1.9 5.2 4.5 3.1 8.9 2.8 5.7 4.5 6.8 4.7 2.5 1.1 4.1 5.4 8.0 8.4 7.2 3.0 2.7 7.5 16.3 5.4 2.5 1.1 1.7 7.1 5.3 0.0 6.5 5.3 9.0 4.2 4.7 4.2 1.7 2.6 6.0 2.8 2.4 9.1 11.7 12.6 7.3 5.3 9.1 3.1 6.9 7.5 6.5 8.5 1.7 4.4 0.0 3.3 4.1 12.5 4.8 8.1 4.8 8.7 10.6 3.9 3.6 10.6 2.1 4.9 20.6 5.8 4.2 3.9 8.4 3.7 6.8 4.5 10.9 8.3 0.8 6.7 10.0 8.9 19.2 9.2 4.3 3.8 7.9 10.3 13.5 3.4 18.1 18.0 7.8 7.3 4.1 8.5 11.0 6.9 21.9 5.7 7.8 5.3 11.0 8.2 16.0 25.2 0.0 9.2 44.0 7.4 0.0 2.8 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.1 2.2 0.0 2.7 0.3 0.0 0.4 4.1 4.7 4.0 7.3 8.9 2.8 2.5 1.1 3.0 0.0 4.2 2.4 5.2 3.2 15.7 68.6 2.1 3.1 2.5 4.1 4.6 41.4 4.9 2.0 8.4 1.5 6.7 7.3 64.6 5.7 13.1 22.7 1.9 3.0 2.5 11.6 18.9 5.4 28.1 0.8 138.9 3.8 4.9 8.7 28.5 5.5 10.8 10.6 5.7 6.0 36.5 58.9 122.9 13.3 2.0 96.1 16.4 3.5 6.5 106.3 3.6 50.6 84.9 8.6 1.0 96.5 50.7 5.2 17.4 9.1 2.1 2.5 24.9 8.1 18.7 31.9 6.6 8.1 8.7 37.2 30.3 2.8 1.7 3.8 3.6 9.1 15.9 2.7 DNA2 "DNA2L, KIAA0083" ENSG00000138346 "DNA replication helicase/nuclease 2" P51530 10 68414064-68472121 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication" "DNA-binding, Endonuclease, Helicase, Hydrolase, Multifunctional enzyme, Nuclease" "Disease variant, Dwarfism, Mental retardation, Primary mitochondrial disease, Progressive external ophthalmoplegia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 8.1" "Cell type enhanced" "Detected in many" "Erythroid cells: 33.2;Excitatory neurons: 14.1;Inhibitory neurons: 15.5;Oligodendrocytes: 18.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 5 "NK-cell: 1.8" "Lineage enriched" "Detected in single" 5 "NK-cells: 1.8" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA037487, HPA057526" Approved Supported Mitochondria No Yes "Cluster 15: NK-cells - Transcription" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Mitochondria "HPA037487: AB_10672493, HPA057526: AB_2683456" "unprognostic (1.79e-1)" "unprognostic (1.35e-1)" "unprognostic (4.37e-3)" "unprognostic (4.60e-3)" "unprognostic (1.53e-1)" "unprognostic (1.86e-2)" "unprognostic (4.50e-5)" "unprognostic (3.36e-2)" "unprognostic (4.70e-2)" "unprognostic (3.72e-2)" "unprognostic (1.30e-2)" "unprognostic (3.29e-4)" "unprognostic (1.09e-10)" "unprognostic (3.43e-2)" "unprognostic (1.98e-1)" "unprognostic (9.36e-2)" "unprognostic (1.23e-2)" 1.3 0.9 1.9 2.8 2.1 4.6 1.8 2.5 3.6 1.4 1.0 2.3 2.1 1.1 0.9 1.9 0.9 0.9 1.8 1.8 1.9 2.6 4.2 1.8 5.2 2.3 1.9 1.2 1.6 0.4 1.5 1.6 2.4 1.9 2.8 5.3 1.6 0.4 1.6 1.8 3.2 1.1 1.6 2.1 1.9 2.9 2.1 8.1 1.0 0.9 4.2 1.4 1.4 3.2 25.6 13.0 29.0 20.7 3.2 2.2 20.4 12.4 10.3 17.4 21.2 31.1 16.1 26.1 4.6 3.8 6.7 15.2 16.8 6.5 20.7 16.2 12.6 15.8 8.5 12.3 0.9 27.7 16.4 1.8 2.6 12.3 3.6 4.5 7.9 17.0 23.6 22.8 10.1 9.0 42.8 19.8 20.5 10.9 24.0 33.1 20.0 8.4 7.5 11.7 13.1 15.7 16.9 21.4 4.2 20.1 16.5 11.6 3.4 6.6 20.5 8.5 23.8 11.5 13.9 38.3 5.7 26.1 8.9 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.2 0.1 0.1 0.0 1.8 0.0 0.0 0.1 0.0 1.9 2.1 2.5 3.6 1.8 1.9 2.3 1.9 2.4 1.6 2.1 3.2 1.0 6.4 1.1 4.9 1.3 2.3 0.9 1.7 2.8 2.5 2.3 1.4 10.5 2.8 1.1 1.8 6.2 3.9 2.2 1.7 0.0 0.8 2.2 2.0 1.4 2.0 1.2 33.2 14.1 0.9 4.8 2.0 2.6 2.8 0.0 6.0 0.7 4.6 2.2 0.0 15.5 1.8 0.0 1.3 0.7 3.7 0.6 1.5 0.0 4.7 0.5 0.5 2.1 5.5 18.4 0.7 0.1 0.7 7.4 2.5 2.4 0.6 0.8 4.3 0.0 2.4 1.1 9.1 12.2 4.7 1.7 1.2 1.6 0.7 3.7 1.0 DNAJB2 "CMT2T, HSJ1, HSPF3" ENSG00000135924 "DnaJ heat shock protein family (Hsp40) member B2" P25686 2 219279342-219286898 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Chaperone Neurodegeneration "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 366.0" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036268 Approved Enhanced "Nuclear membrane" NA NA 9900 "Cluster 52: Eosinophils - Transcription" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 30: Epithelial cell lines - Translation" "Cluster 30: Mammary glandular cells - Lactation" "Nuclear membrane" "HPA036268: AB_10670793" "unprognostic (2.02e-2)" "unprognostic (3.69e-2)" "prognostic unfavorable (1.01e-4)" "unprognostic (2.53e-2)" "unprognostic (1.57e-1)" "unprognostic (2.35e-1)" "unprognostic (1.45e-3)" "unprognostic (5.11e-2)" "unprognostic (2.11e-2)" "unprognostic (1.40e-1)" "unprognostic (1.16e-3)" "unprognostic (7.03e-2)" "unprognostic (4.09e-2)" "unprognostic (4.64e-2)" "unprognostic (1.96e-2)" "unprognostic (5.98e-2)" "unprognostic (5.62e-3)" 41.9 106.9 264.5 17.7 290.6 26.6 45.7 276.0 323.5 63.8 232.0 48.9 23.2 46.2 45.2 54.1 48.2 26.6 85.4 266.6 270.7 81.0 72.1 45.8 26.0 281.8 281.8 65.0 84.8 54.3 112.1 27.1 279.7 73.9 15.8 63.9 62.3 35.5 135.6 108.1 36.0 15.8 269.7 46.7 54.8 86.0 280.5 28.4 71.0 56.5 20.5 52.8 59.0 366.0 34.9 14.2 21.9 20.7 45.6 22.1 29.3 32.8 27.2 29.0 24.2 66.2 21.3 21.4 39.7 31.6 66.3 49.1 27.9 36.3 16.3 45.3 12.2 41.7 28.0 32.0 30.8 7.1 36.5 21.3 103.3 31.8 38.4 51.3 12.9 23.5 7.4 23.7 21.4 18.0 13.0 8.4 12.9 30.2 26.4 13.4 17.9 13.5 31.7 24.5 20.6 26.0 38.0 38.4 64.9 57.5 28.6 14.9 17.5 41.6 82.3 12.0 28.6 26.2 8.4 35.0 42.8 6.5 31.1 0.0 0.4 2.1 0.7 0.4 0.6 0.5 0.7 0.6 0.2 1.7 1.0 0.9 0.4 1.3 1.2 0.6 1.0 0.4 264.5 290.6 276.0 323.5 266.6 270.7 281.8 281.8 279.7 269.7 280.5 366.0 24.6 19.2 31.4 35.6 30.9 28.6 40.9 17.1 9.1 97.9 61.9 33.9 77.4 25.8 18.0 38.6 56.3 36.1 24.0 41.5 78.2 60.0 43.8 43.5 16.2 22.3 53.7 69.9 17.9 33.5 34.7 27.5 22.4 27.9 24.8 22.1 20.7 20.5 28.2 80.8 26.5 47.5 10.2 19.7 28.2 70.9 36.4 28.0 32.0 11.2 21.6 84.8 15.5 16.6 144.2 68.9 23.6 39.1 28.5 39.8 31.7 56.5 39.0 87.3 19.7 27.3 28.3 56.5 20.6 18.9 50.4 69.0 30.2 23.1 25.5 25.8 DNAJC13 "KIAA0678, RME8" ENSG00000138246 "DnaJ heat shock protein family (Hsp40) member C13" O75165 3 132417502-132539032 "Human disease related genes, Predicted membrane proteins" "Protein transport, Transport" Chaperone "Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036923, HPA036924" Approved Supported Vesicles,Cytosol NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 10: Non-specific - Unknown function" Vesicles Cytosol "HPA036923: AB_10672480, HPA036924: AB_2675386" "unprognostic (3.35e-3)" "unprognostic (7.47e-2)" "unprognostic (9.16e-2)" "unprognostic (1.20e-2)" "unprognostic (9.71e-2)" "unprognostic (4.92e-2)" "prognostic unfavorable (7.49e-4)" "unprognostic (3.68e-2)" "unprognostic (3.38e-1)" "unprognostic (1.92e-1)" "prognostic unfavorable (8.36e-4)" "unprognostic (1.92e-1)" "unprognostic (4.81e-3)" "unprognostic (2.15e-1)" "unprognostic (1.71e-1)" "unprognostic (2.34e-2)" "unprognostic (1.22e-1)" 11.7 9.4 5.9 12.4 6.5 15.5 11.4 6.0 6.3 12.9 8.2 14.4 10.9 13.8 11.7 10.7 9.9 9.9 12.9 5.9 6.9 16.0 9.8 11.3 11.0 7.7 6.9 11.7 6.8 12.6 5.9 15.4 7.1 10.8 14.3 10.7 9.1 12.1 12.5 9.8 10.4 16.7 6.3 12.2 9.7 7.8 7.5 12.0 15.7 14.2 10.6 12.4 10.3 7.8 31.0 18.0 22.2 10.9 54.3 46.7 13.7 32.3 62.5 31.4 33.8 20.4 18.2 15.7 20.5 46.3 41.1 24.1 22.1 24.3 43.5 18.3 6.4 20.6 17.1 13.6 27.6 21.1 18.3 34.2 16.4 28.5 35.1 22.7 44.6 26.0 11.4 25.6 43.7 24.1 16.8 9.1 12.7 26.7 15.8 15.9 16.5 13.0 27.7 32.4 7.9 11.9 31.6 16.7 36.1 19.0 24.7 17.8 40.9 34.7 17.8 33.3 13.9 14.8 15.7 21.5 36.8 13.6 25.2 2.0 2.6 0.4 0.8 2.2 0.7 1.0 0.9 0.7 2.8 0.4 0.6 0.8 0.5 0.7 4.0 1.4 0.4 0.8 5.9 6.5 6.0 6.3 5.9 6.9 7.7 6.9 7.1 6.3 7.5 7.8 16.8 12.8 21.9 45.7 14.4 6.6 7.3 7.3 6.8 10.8 8.9 7.2 47.2 8.6 11.3 12.9 33.3 7.9 13.2 21.5 1.9 9.0 1.7 10.3 31.3 17.1 14.4 12.8 48.7 9.1 7.7 20.2 16.8 18.7 12.0 18.9 13.2 8.5 20.5 67.3 48.7 12.5 0.0 34.2 9.2 3.6 15.2 26.5 28.4 60.0 25.1 13.3 6.2 46.8 64.7 11.7 12.5 21.4 13.9 10.5 17.0 18.7 13.1 11.5 6.6 22.3 19.7 5.3 13.7 15.4 7.5 5.1 10.8 22.5 13.4 11.0 DNAJC16 KIAA0962 ENSG00000116138 "DnaJ heat shock protein family (Hsp40) member C16" Q9Y2G8 1 15526813-15592379 "Human disease related genes, Predicted membrane proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043643 Approved Approved Vesicles NA NA "Cluster 32: T-cells - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 1: K-562 - Erythropoiesis" "Cluster 49: Ciliated cells - Cilium organization" Vesicles "HPA043643: AB_10796794" "unprognostic (1.77e-1)" "unprognostic (4.95e-2)" "prognostic favorable (6.77e-4)" "unprognostic (4.52e-2)" "unprognostic (5.51e-2)" "unprognostic (2.05e-2)" "unprognostic (1.91e-2)" "unprognostic (2.15e-1)" "unprognostic (1.29e-1)" "unprognostic (4.28e-2)" "unprognostic (2.35e-2)" "unprognostic (3.74e-2)" "prognostic favorable (7.24e-4)" "unprognostic (3.67e-2)" "unprognostic (3.74e-1)" "unprognostic (5.38e-2)" "unprognostic (4.70e-2)" 4.9 5.2 4.5 5.5 5.3 2.2 6.5 5.4 6.5 5.0 7.8 6.0 6.5 5.6 7.6 5.4 6.8 4.5 5.1 5.3 4.9 11.5 10.1 4.8 6.2 4.2 4.4 5.7 6.4 10.0 5.3 5.8 4.8 5.5 5.9 9.0 7.0 4.8 11.9 5.6 5.8 6.3 4.1 5.7 5.4 6.3 5.0 5.1 7.4 6.3 6.4 5.2 4.6 6.4 8.8 8.7 6.7 12.4 18.0 14.5 6.3 10.4 10.7 10.2 10.9 7.1 12.7 7.6 6.8 10.3 13.3 10.7 8.3 9.2 14.3 9.0 4.0 7.8 9.6 12.2 17.8 12.2 8.7 10.5 10.6 16.4 9.2 12.7 11.6 6.3 16.9 6.7 11.8 3.6 6.2 6.2 6.5 7.9 5.6 7.3 8.6 8.5 12.6 6.0 7.5 7.0 10.6 10.1 9.0 9.6 6.3 4.8 15.7 17.9 6.4 16.7 5.7 9.1 13.8 6.6 11.1 6.9 8.7 2.0 2.1 1.5 2.6 2.0 3.9 3.4 2.8 2.4 2.1 3.1 3.5 3.0 1.1 1.6 1.5 1.9 2.8 1.9 4.5 5.3 5.4 6.5 5.3 4.9 4.2 4.4 4.8 4.1 5.0 6.4 11.6 0.0 8.7 25.5 12.4 5.1 4.3 13.8 9.6 14.9 16.1 8.4 16.9 22.8 14.9 25.8 22.9 12.8 11.5 13.7 1.9 9.1 11.6 25.5 19.0 12.0 11.5 4.6 33.5 6.9 7.7 10.5 11.7 17.6 8.2 14.0 16.4 20.5 10.9 18.5 28.6 9.7 18.3 20.6 5.5 5.8 12.5 9.5 7.2 17.8 11.4 12.8 12.3 19.1 28.8 9.3 7.5 11.3 6.8 12.6 10.6 19.0 37.5 16.0 6.6 11.7 7.8 24.7 15.7 13.0 5.8 22.0 7.1 11.4 13.4 8.2 DNAJC3 "ERdj6, HP58, P58, p58(IPK), P58IPK, PRKRI" ENSG00000102580 "DnaJ heat shock protein family (Hsp40) member C3" Q13217 13 95677139-95794988 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Antiviral defense, Stress response, Translation regulation, Unfolded protein response" "Chaperone, Repressor" "Deafness, Diabetes mellitus, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039336, HPA041326" Uncertain Approved "Endoplasmic reticulum" "Intracellular and membrane" NA NA 4900000 "Cluster 49: Eosinophils - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 55: Plasma cells - Humoral immune response" "Endoplasmic reticulum" "HPA039336: AB_2676451, HPA041326: AB_2677412" "unprognostic (1.44e-2)" "unprognostic (8.08e-2)" "unprognostic (2.12e-2)" "prognostic favorable (3.47e-5)" "unprognostic (8.18e-2)" "unprognostic (5.78e-2)" "unprognostic (1.09e-1)" "unprognostic (2.19e-2)" "unprognostic (1.31e-1)" "unprognostic (2.45e-1)" "unprognostic (1.20e-1)" "unprognostic (1.64e-1)" "unprognostic (9.69e-2)" "unprognostic (7.19e-2)" "unprognostic (3.37e-2)" "unprognostic (8.30e-3)" "unprognostic (8.18e-2)" 21.0 20.0 10.7 22.5 13.0 45.6 21.3 13.0 11.4 35.1 22.3 25.2 23.8 20.4 38.9 15.9 20.4 22.0 16.6 10.0 14.1 25.5 41.8 22.9 15.0 15.1 12.5 15.8 36.0 24.4 16.2 24.7 15.5 34.5 26.4 9.9 36.3 26.0 9.3 10.9 24.0 22.3 13.4 19.8 28.8 12.7 14.6 11.3 52.8 11.2 17.8 22.1 11.9 16.4 32.4 18.0 14.2 40.7 57.7 28.6 42.6 44.6 40.3 20.2 18.4 22.7 66.5 29.5 41.5 45.0 28.5 32.3 18.7 34.1 30.7 28.8 8.4 40.7 24.6 36.5 79.1 49.8 51.6 34.3 35.7 29.7 68.2 36.9 44.4 13.2 13.9 0.3 34.4 13.1 17.0 17.8 10.6 75.2 13.9 17.1 24.8 22.9 44.9 39.5 8.2 15.6 31.6 74.9 22.5 32.4 37.3 54.6 50.8 39.0 13.3 26.2 23.3 60.6 28.4 13.4 65.6 29.6 54.9 64.7 25.5 86.2 23.9 32.1 25.3 11.2 19.6 20.1 17.2 9.0 13.7 18.7 77.1 22.8 36.0 45.9 13.4 15.7 10.7 13.0 13.0 11.4 10.0 14.1 15.1 12.5 15.5 13.4 14.6 16.4 81.7 80.1 71.3 47.3 61.1 94.1 88.5 81.1 33.6 25.7 65.2 35.9 58.2 81.5 83.4 47.8 27.1 57.1 109.6 69.0 21.5 98.8 160.5 58.0 87.5 64.8 41.9 33.7 30.1 118.7 135.5 99.6 56.6 94.5 67.8 34.4 68.6 140.7 78.8 25.2 37.3 84.9 69.2 70.5 130.2 33.6 71.7 82.0 119.2 47.8 63.1 38.7 51.5 53.3 58.9 97.6 52.4 75.6 214.3 151.2 58.1 71.1 96.7 19.6 92.1 80.8 104.5 47.1 79.9 38.1 92.9 189.8 67.0 53.3 63.8 124.4 DNAL4 "dJ327J16, PIG27" ENSG00000100246 "Dynein axonemal light chain 4" O96015 22 38778508-38794198 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Motor protein" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 124.1;Late spermatids: 210.7;Spermatocytes: 77.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "hTCEpi: 64.0" "Low region specificity" "Detected in all" HPA003647 Approved Approved Nucleoplasm,Nucleoli,Centrosome,Cytosol NA NA "Cluster 10: Basophils - Unknown function" "Cluster 43: Testis - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 31: Spermatids - Spermatogenesis" Centrosome "Nucleoplasm, Nucleoli, Cytosol" "HPA003647: AB_1078712" "unprognostic (8.45e-2)" "unprognostic (8.15e-3)" "unprognostic (2.35e-1)" "unprognostic (3.14e-3)" "unprognostic (3.74e-1)" "unprognostic (1.52e-1)" "unprognostic (6.46e-3)" "unprognostic (2.81e-1)" "unprognostic (3.32e-1)" "unprognostic (1.81e-1)" "unprognostic (2.06e-1)" "unprognostic (2.07e-1)" "prognostic favorable (1.20e-6)" "unprognostic (1.60e-1)" "unprognostic (1.10e-1)" "unprognostic (8.00e-2)" "unprognostic (4.83e-2)" 11.3 18.0 29.1 6.7 32.3 4.4 14.5 21.0 36.5 18.3 23.2 12.9 7.9 12.2 15.0 18.9 35.4 12.9 13.7 29.2 28.3 24.4 11.1 13.9 8.1 22.1 23.3 17.5 21.3 31.1 30.9 9.9 22.1 18.3 9.6 13.8 18.1 12.1 7.0 17.5 9.8 7.5 22.0 11.4 16.4 65.5 28.0 14.3 25.4 6.2 8.3 14.2 15.5 24.5 17.9 8.9 17.5 15.5 21.8 21.7 0.0 7.5 14.0 11.4 12.2 5.7 20.1 4.5 15.7 10.7 13.1 8.3 11.0 20.5 7.7 11.4 14.8 2.6 2.5 6.6 34.9 14.5 3.7 17.1 64.0 14.9 26.8 29.7 16.6 22.1 5.3 8.5 13.8 21.9 13.6 14.0 6.8 26.3 7.4 12.8 7.5 5.9 23.7 10.8 24.3 13.5 15.4 11.5 30.7 12.1 20.7 13.7 9.8 10.1 10.1 15.5 7.5 5.3 1.8 2.1 29.9 4.9 9.8 15.0 8.5 11.9 11.2 8.9 13.8 7.1 9.3 10.2 8.7 10.6 10.5 9.0 15.0 16.2 11.3 13.2 9.3 7.5 29.1 32.3 21.0 36.5 29.2 28.3 22.1 23.3 22.1 22.0 28.0 24.5 8.2 6.4 10.5 5.5 5.1 5.6 13.4 18.9 10.2 15.0 20.6 17.8 4.3 14.3 15.2 3.7 2.1 27.6 9.7 10.9 31.3 28.4 124.1 56.4 11.8 8.5 12.6 11.2 11.0 15.5 21.2 10.1 6.1 10.5 15.2 20.3 12.8 3.8 13.7 11.8 10.6 14.7 14.2 4.4 2.8 210.7 11.8 6.5 8.8 4.7 5.7 18.9 8.2 6.6 5.1 18.4 9.1 7.5 1.3 9.8 8.5 20.0 41.0 15.4 6.6 6.6 11.6 77.7 20.0 9.1 10.5 19.8 6.0 20.1 13.2 12.0 DNM1 DNM ENSG00000106976 "Dynamin 1" Q05193 9 128191655-128255248 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Endocytosis "Hydrolase, Motor protein" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "brain: 319.5" "Cell type enhanced" "Detected in many" "Bipolar cells: 112.4;Cone photoreceptor cells: 89.6;Excitatory neurons: 176.1;Inhibitory neurons: 182.2;Rod photoreceptor cells: 78.4" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in many" "cerebral cortex: 319.5" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 126.9;U-87 MG: 46.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005920, HPA049910" Enhanced NA NA 8800 "Cluster 10: Brain - Neuronal signaling" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB005920: , HPA049910: AB_2680948" "unprognostic (3.25e-2)" "unprognostic (5.49e-2)" "unprognostic (1.34e-3)" "unprognostic (3.95e-2)" "unprognostic (4.57e-2)" "unprognostic (1.16e-1)" "unprognostic (3.60e-3)" "unprognostic (1.20e-1)" "unprognostic (5.53e-2)" "unprognostic (6.53e-2)" "unprognostic (6.62e-3)" "unprognostic (6.30e-1)" "unprognostic (9.58e-2)" "unprognostic (1.10e-1)" "unprognostic (2.02e-1)" "unprognostic (3.07e-3)" "unprognostic (1.10e-3)" 22.2 7.9 99.8 3.7 129.1 2.0 13.2 13.6 319.5 30.8 0.0 8.0 1.9 8.8 2.4 5.5 9.4 13.4 7.8 140.1 15.9 14.1 5.3 4.6 2.4 50.7 4.1 2.5 8.4 4.1 33.6 2.5 36.6 9.0 2.7 68.3 9.0 3.0 3.2 15.0 9.0 5.3 0.0 1.0 5.0 4.9 10.0 0.9 5.2 4.0 1.8 10.6 21.6 123.1 8.7 126.9 11.3 2.8 3.6 36.8 0.6 8.0 18.9 15.7 6.5 1.7 2.6 0.2 10.7 16.7 0.6 15.3 1.8 0.8 8.6 0.1 12.1 8.3 19.5 0.5 2.6 1.1 5.6 9.8 0.2 12.4 0.2 15.2 0.0 7.3 3.1 0.5 0.0 3.6 0.7 2.7 12.2 2.2 23.1 15.6 0.4 3.9 2.4 0.0 16.1 27.1 27.1 0.8 1.2 1.4 0.3 11.2 0.6 0.5 34.8 36.2 16.6 1.0 0.4 0.8 46.8 0.4 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 99.8 129.1 13.6 319.5 140.1 15.9 50.7 4.1 36.6 0.0 10.0 123.1 2.2 0.0 0.0 18.9 0.9 7.9 1.7 0.3 8.0 112.4 2.9 3.9 2.0 5.7 0.8 0.0 89.6 0.3 0.2 0.4 1.9 0.8 0.9 1.3 19.0 1.8 0.0 0.0 176.1 0.9 0.4 24.3 2.6 1.4 1.3 2.8 0.7 0.6 10.6 50.5 182.2 0.9 0.0 0.6 10.5 1.0 2.8 9.2 3.6 22.5 1.3 10.7 0.0 33.7 14.3 0.6 5.0 1.5 0.7 0.8 2.5 5.3 1.1 78.4 0.0 2.1 3.8 1.0 1.8 2.5 7.5 0.8 1.6 2.1 1.6 0.8 DNM1L "DRP1, DVLP, DYMPLE, HDYNIV, VPS1" ENSG00000087470 "Dynamin 1 like" O00429 12 32679200-32745650 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Biological rhythms, Endocytosis, Necrosis" Hydrolase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009952, HPA039324" Approved Enhanced Vesicles,Cytosol NA NA 2000000 "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 5: NTERA-2 - Transcription" "Cluster 46: Photoreceptor cells - Phototransduction" Cytosol Vesicles "CAB009952: AB_2093533, HPA039324: AB_2676443" "unprognostic (2.64e-2)" "unprognostic (2.94e-1)" "unprognostic (1.10e-3)" "unprognostic (1.12e-1)" "unprognostic (5.09e-1)" "unprognostic (4.06e-2)" "prognostic unfavorable (6.27e-6)" "unprognostic (8.68e-2)" "unprognostic (2.25e-2)" "unprognostic (1.04e-2)" "unprognostic (1.71e-1)" "unprognostic (2.63e-1)" "unprognostic (4.06e-1)" "unprognostic (1.00e-1)" "unprognostic (8.17e-2)" "unprognostic (7.48e-2)" "unprognostic (1.57e-2)" 23.2 23.2 25.3 23.5 27.5 40.0 21.1 27.7 32.3 18.4 15.7 24.0 18.6 23.6 23.9 28.6 19.8 17.5 38.9 28.4 26.1 27.9 14.2 16.7 20.9 22.5 22.0 20.0 13.5 40.5 25.3 23.9 23.6 27.0 22.7 44.9 16.0 28.7 43.8 18.3 16.8 32.0 22.2 18.8 17.3 36.0 21.6 21.4 22.4 57.2 24.8 29.9 18.5 26.6 66.8 62.3 64.3 68.3 51.2 52.7 123.2 72.0 55.4 67.2 61.7 80.6 48.0 87.3 50.0 65.8 66.9 57.8 69.2 80.3 79.3 46.6 57.6 102.3 57.2 48.2 41.7 72.5 50.1 48.6 37.4 70.7 66.1 63.5 81.1 41.4 74.4 37.5 75.3 21.7 29.1 61.7 138.2 41.0 30.8 48.6 125.0 61.5 56.5 79.1 57.1 59.3 76.3 51.8 56.7 129.4 59.7 49.0 74.0 57.3 54.4 135.3 68.2 26.1 75.8 86.3 55.6 47.0 43.5 7.4 10.0 3.2 5.6 15.6 6.9 7.0 6.2 6.1 18.8 6.0 7.3 8.4 1.8 8.1 15.6 5.6 7.3 7.9 25.3 27.5 27.7 32.3 28.4 26.1 22.5 22.0 23.6 22.2 21.6 26.6 42.5 38.5 38.4 82.6 36.0 30.0 34.7 28.0 44.3 80.9 32.5 29.2 82.8 20.0 33.3 25.8 131.3 30.0 53.8 26.7 31.3 34.8 63.9 38.8 55.8 42.0 30.5 28.4 139.4 25.1 63.7 41.0 23.9 59.4 50.7 48.8 26.4 16.0 30.8 126.2 150.0 24.9 34.6 27.5 30.7 78.0 26.8 43.3 14.2 44.0 45.6 59.0 34.0 99.5 121.7 45.7 14.4 30.5 48.5 42.8 11.4 23.3 22.8 164.8 19.7 55.0 55.5 79.3 52.3 39.6 27.6 36.0 42.2 26.0 31.5 36.4 DNM2 "CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII" ENSG00000079805 "Dynamin 2" P50570 19 10718079-10833488 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Endocytosis, Phagocytosis" "Hydrolase, Motor protein" "Cancer-related genes, Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 242.8;Paneth cells: 177.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054246 Supported Approved "Golgi apparatus,Cytosol" NA NA 230000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Golgi apparatus, Cytosol" "HPA054246: AB_2682427" "unprognostic (2.30e-1)" "unprognostic (5.23e-2)" "unprognostic (4.72e-2)" "unprognostic (1.23e-1)" "unprognostic (1.76e-1)" "prognostic favorable (8.91e-4)" "prognostic unfavorable (3.63e-4)" "unprognostic (1.03e-1)" "unprognostic (3.79e-1)" "unprognostic (1.89e-1)" "unprognostic (4.75e-2)" "unprognostic (5.35e-2)" "unprognostic (5.47e-2)" "unprognostic (5.40e-3)" "unprognostic (2.68e-1)" "unprognostic (1.61e-1)" "unprognostic (1.99e-3)" 55.1 69.9 50.5 63.2 77.8 125.7 46.1 74.1 64.1 49.0 38.8 105.8 65.9 42.2 25.3 67.6 42.5 40.5 87.2 52.3 57.4 72.8 57.2 87.0 62.4 82.7 78.9 36.6 68.2 38.9 41.9 51.3 79.8 47.4 83.9 30.7 55.0 55.7 108.1 92.8 99.6 35.1 60.3 81.0 98.6 55.1 72.9 58.6 47.6 82.8 65.4 64.6 54.5 101.6 116.4 92.8 67.6 54.6 67.6 65.4 86.5 75.1 70.5 108.8 91.7 94.2 74.7 83.2 132.2 81.5 52.5 99.4 92.6 82.1 90.8 103.1 72.4 160.1 81.7 107.1 82.9 87.8 146.5 67.8 62.4 83.5 77.9 66.2 107.3 84.9 131.5 139.1 68.0 140.1 126.3 85.7 76.6 138.3 109.7 125.6 72.6 95.7 71.3 171.1 97.1 63.8 86.6 73.6 54.2 74.9 58.8 106.2 99.6 120.7 40.5 172.0 102.7 112.7 127.3 77.9 89.9 134.0 61.0 3.5 3.5 7.0 4.0 6.2 3.8 2.5 3.0 4.4 4.2 2.1 1.7 3.0 6.5 8.9 8.4 8.4 3.8 4.1 50.5 77.8 74.1 64.1 52.3 57.4 82.7 78.9 79.8 60.3 72.9 101.6 37.8 32.1 22.3 24.8 48.8 23.2 17.1 13.8 22.2 28.8 19.7 16.3 30.3 14.3 25.7 51.5 22.9 25.7 57.2 242.8 50.9 35.2 48.4 32.2 17.9 33.1 21.6 38.1 29.2 32.0 106.9 19.5 168.7 39.7 19.0 36.8 20.3 22.8 49.1 43.7 31.1 106.9 14.2 28.0 39.6 98.0 16.8 55.2 19.6 60.9 43.4 17.2 39.1 23.1 90.9 45.2 177.3 27.8 92.2 20.2 90.7 38.8 18.0 26.3 26.3 18.7 27.6 15.0 12.3 26.6 31.5 31.7 46.4 40.7 82.5 22.8 DNMBP "ARHGEF36, KIAA1010, Tuba" ENSG00000107554 "Dynamin binding protein" Q6XZF7 10 99875577-100009947 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Guanine-nucleotide releasing factor" "Cataract, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "hTERT-RPE1: 75.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037878, HPA058216" Uncertain Approved "Nucleoli,Nuclear bodies,Golgi apparatus,Cytosol" Yes No "Cluster 15: NK-cells - Transcription" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 41: Macrophages - Immune response" "Nucleoli, Golgi apparatus, Cytosol" "Nuclear bodies" "HPA037878: AB_10675622, HPA058216: AB_2683640" "unprognostic (3.25e-1)" "unprognostic (8.19e-2)" "unprognostic (1.86e-1)" "prognostic favorable (4.95e-6)" "unprognostic (3.92e-2)" "unprognostic (4.13e-1)" "unprognostic (9.79e-2)" "unprognostic (4.07e-1)" "unprognostic (1.90e-1)" "unprognostic (1.02e-1)" "unprognostic (8.67e-3)" "unprognostic (4.03e-2)" "unprognostic (5.07e-3)" "unprognostic (6.52e-2)" "unprognostic (4.95e-2)" "unprognostic (1.28e-1)" "prognostic favorable (6.15e-4)" 13.6 6.0 3.6 5.5 3.7 10.3 10.2 6.2 5.3 15.8 8.6 17.7 22.5 9.6 12.5 10.2 11.3 11.0 7.5 4.7 4.2 20.6 13.1 8.4 4.6 3.7 3.6 11.5 17.6 31.7 3.9 10.5 3.8 8.9 20.7 15.8 8.4 12.8 13.4 27.4 27.2 8.8 3.0 7.7 23.8 6.9 5.2 20.1 8.1 11.1 5.2 19.8 17.7 3.1 25.7 20.7 18.4 29.2 32.9 27.4 4.4 45.2 43.6 21.5 20.7 14.2 38.0 26.6 18.9 34.9 11.8 19.9 21.6 26.1 29.9 1.4 6.7 3.8 23.7 10.0 17.1 2.6 1.8 13.0 5.7 26.6 23.4 75.5 52.1 8.5 3.6 0.0 44.1 3.2 4.5 5.1 17.7 18.0 12.3 5.5 18.7 1.4 36.6 21.9 3.1 4.2 7.4 1.9 5.7 25.3 1.5 2.4 63.4 16.0 15.3 13.1 29.8 2.1 1.7 36.3 15.2 8.4 12.2 0.0 0.8 0.2 0.7 1.2 0.7 1.2 0.1 0.4 0.3 1.9 0.1 0.3 0.7 2.1 1.2 0.3 0.0 0.6 3.6 3.7 6.2 5.3 4.7 4.2 3.7 3.6 3.8 3.0 5.2 3.1 6.8 9.6 11.0 11.1 14.8 35.1 7.2 5.0 5.2 6.3 9.3 6.3 6.1 12.8 11.2 12.9 35.5 7.7 4.4 36.7 3.9 7.5 1.0 27.0 11.0 12.6 3.6 0.0 15.9 14.3 1.4 17.6 26.0 43.9 2.5 4.1 11.4 12.8 4.7 13.5 24.8 25.0 6.1 10.7 9.6 3.2 13.7 20.5 3.6 23.4 3.3 4.3 0.0 10.6 2.6 19.3 23.6 9.1 6.1 4.0 36.5 3.7 19.9 26.6 0.0 4.3 6.9 4.2 9.3 9.0 45.6 3.7 4.3 15.0 28.4 21.8 DNMT1 "CXXC9, DNMT, MCMT" ENSG00000130816 "DNA methyltransferase 1" P26358 19 10133342-10231286 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Chromatin regulator, DNA-binding, Methyltransferase, Repressor, Transferase" "Deafness, Disease variant, FDA approved drug targets, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 388.1;Spermatocytes: 229.6;Syncytiotrophoblasts: 323.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002694, CAB005876" Enhanced Supported Nucleoplasm NA Yes "Cluster 6: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Nucleoplasm "CAB005876: AB_731983, HPA002694: AB_1847810" "unprognostic (3.51e-1)" "unprognostic (1.20e-2)" "unprognostic (1.26e-2)" "unprognostic (1.40e-1)" "unprognostic (3.62e-1)" "unprognostic (7.59e-3)" "prognostic unfavorable (1.46e-4)" "unprognostic (2.90e-1)" "unprognostic (4.23e-3)" "unprognostic (1.10e-2)" "unprognostic (1.07e-1)" "unprognostic (1.11e-2)" "unprognostic (1.28e-3)" "unprognostic (7.81e-3)" "unprognostic (1.73e-1)" "unprognostic (8.11e-2)" "unprognostic (1.46e-1)" 7.1 3.9 0.9 16.9 2.9 23.1 7.0 11.7 3.1 9.1 0.0 6.9 6.6 7.3 3.1 7.7 6.5 6.2 4.8 2.1 6.6 3.0 3.9 7.8 26.2 3.8 4.5 5.6 3.6 4.3 4.5 26.0 5.7 4.5 6.8 7.5 5.6 4.6 5.3 7.9 7.9 8.8 0.3 8.1 6.3 12.4 3.3 20.6 6.3 5.0 24.9 7.3 6.4 10.6 77.0 40.6 49.5 45.8 24.6 24.0 138.8 52.4 43.9 77.5 74.9 50.6 40.8 138.3 33.8 30.0 38.6 46.6 68.4 44.2 68.4 57.5 100.9 181.5 39.5 27.1 9.6 91.5 73.4 11.5 9.3 68.5 24.1 18.4 39.9 37.6 75.0 82.8 63.3 37.6 109.2 50.4 87.5 38.3 76.6 117.1 67.9 77.2 21.5 49.3 64.5 41.5 58.2 26.2 16.5 33.6 28.9 42.2 31.8 111.3 42.2 73.0 84.4 49.6 69.5 166.8 35.0 68.5 87.1 20.3 21.2 5.9 29.8 22.0 25.1 14.2 22.8 20.4 19.3 20.0 25.5 20.5 4.6 42.6 13.8 31.9 21.9 12.6 0.9 2.9 11.7 3.1 2.1 6.6 3.8 4.5 5.7 0.3 3.3 10.6 36.4 6.4 26.5 12.7 38.0 29.6 20.7 26.8 21.1 86.7 32.6 29.6 14.6 7.2 28.2 22.0 56.3 388.1 54.4 29.0 13.7 26.0 46.1 48.1 42.0 38.9 15.7 109.6 17.6 14.3 73.2 33.6 33.6 60.3 37.2 43.6 25.0 14.8 76.8 65.6 22.6 25.5 38.7 31.4 47.8 50.8 28.0 57.9 14.2 15.0 52.5 32.2 123.6 14.6 20.1 21.1 11.3 28.6 73.4 16.3 4.5 9.3 42.8 50.2 13.1 22.6 32.8 229.6 145.3 41.6 22.4 323.7 70.4 38.7 43.1 16.6 DOCK7 "KIAA1771, ZIR2" ENSG00000116641 "Dedicator of cytokinesis 7" Q96N67 1 62454298-62688386 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Differentiation, Neurogenesis" "Developmental protein, Guanine-nucleotide releasing factor" Epilepsy "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 347.0;Inhibitory neurons: 103.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "myeloid DC: 1.4" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 64: Astrocytes - Nervous system maintenance" "unprognostic (2.07e-1)" "unprognostic (1.35e-2)" "unprognostic (2.69e-2)" "unprognostic (1.44e-1)" "unprognostic (4.51e-1)" "unprognostic (1.87e-1)" "prognostic unfavorable (1.12e-4)" "unprognostic (4.90e-2)" "unprognostic (6.34e-2)" "unprognostic (1.10e-2)" "unprognostic (3.74e-3)" "unprognostic (1.18e-1)" "unprognostic (8.16e-2)" "unprognostic (4.29e-2)" "unprognostic (2.01e-1)" "unprognostic (2.62e-1)" "unprognostic (3.99e-2)" 9.9 5.9 11.3 6.6 13.6 3.1 12.4 9.6 11.6 10.7 7.2 9.9 7.0 10.7 7.7 6.5 9.4 8.3 5.9 10.3 13.6 8.9 8.0 6.4 4.3 11.3 11.9 15.4 5.8 13.9 10.9 9.9 12.4 10.2 11.3 12.6 9.8 7.9 3.6 9.8 6.7 10.4 12.9 6.1 10.6 16.4 11.4 7.3 6.3 3.7 4.8 9.0 8.0 15.2 30.8 12.3 48.8 10.9 45.8 49.6 22.6 41.9 37.5 35.6 33.5 13.4 9.6 13.3 9.4 56.6 42.4 16.2 23.7 34.4 57.9 15.9 18.2 24.1 11.8 25.0 20.8 11.1 8.7 30.0 15.8 43.5 38.4 42.8 17.8 12.7 11.7 5.0 43.2 9.2 8.7 0.8 26.3 6.6 14.3 10.6 53.1 3.7 28.9 26.4 15.3 49.2 23.5 24.6 51.9 42.9 7.8 8.5 31.7 37.6 21.4 37.3 31.5 9.3 12.7 7.2 32.1 2.7 40.0 0.0 0.4 0.0 0.2 0.7 0.6 0.5 0.1 0.4 1.4 0.2 0.1 0.4 0.0 0.1 0.2 0.3 0.1 0.2 11.3 13.6 9.6 11.6 10.3 13.6 11.3 11.9 12.4 12.9 11.4 15.2 5.3 9.6 10.1 347.0 9.1 11.9 18.3 11.1 20.5 15.4 16.3 18.4 12.2 10.0 9.6 23.9 22.9 11.8 3.8 10.1 1.9 19.9 2.2 16.9 29.6 6.1 13.1 7.6 84.8 16.0 17.1 19.5 22.4 24.1 5.7 29.2 6.1 16.6 15.3 20.2 103.9 11.5 14.2 8.7 9.5 4.5 23.0 13.1 12.4 61.8 7.0 23.8 3.1 53.8 25.9 26.5 14.5 23.0 5.7 18.3 9.4 9.7 12.4 18.5 6.6 15.8 23.4 48.8 43.9 12.6 7.7 11.6 4.7 15.7 15.6 13.8 DOK7 "C4orf25, Dok-7, FLJ33718, FLJ39137" ENSG00000175920 "Docking protein 7" Q18PE1 4 3463306-3501473 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 41.9;skeletal muscle: 29.5" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 17.1;Enteroendocrine cells: 6.0;Late spermatids: 9.9" "Cancer enhanced" "Detected in many" "ovarian cancer: 11.0" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 16 "memory B-cell: 3.4;naive B-cell: 2.3;NK-cell: 1.9" "Group enriched" "Detected in many" 16 "B-cells: 3.4;NK-cells: 1.9" "Cell line enriched" "Detected in some" 4 "MCF7: 36.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA059449, HPA062780" Approved Enhanced Nucleoplasm,Mitochondria NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 38: Heart - Muscle contraction" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm Mitochondria "HPA059449: AB_2684023, HPA062780: AB_2732688" "prognostic favorable (8.45e-5)" "unprognostic (2.34e-1)" "unprognostic (2.08e-2)" "prognostic favorable (2.19e-4)" "unprognostic (5.96e-2)" "unprognostic (6.80e-3)" "unprognostic (1.05e-2)" "unprognostic (9.54e-2)" "unprognostic (1.12e-2)" "unprognostic (5.75e-2)" "unprognostic (2.54e-1)" "unprognostic (8.70e-2)" "unprognostic (1.24e-4)" "unprognostic (4.61e-3)" "unprognostic (5.09e-1)" "unprognostic (3.16e-2)" "prognostic favorable (1.28e-4)" 0.1 0.9 1.0 0.2 4.7 0.2 0.4 7.8 2.9 2.1 11.1 0.3 0.1 1.0 1.7 0.3 5.9 0.3 41.9 1.1 0.9 2.7 1.1 1.6 0.7 4.2 1.5 0.3 5.8 0.1 15.7 0.0 4.7 1.8 0.1 0.0 1.9 1.0 29.5 1.6 1.4 0.0 0.2 1.9 2.7 4.8 3.0 0.0 0.7 8.8 0.4 1.2 0.6 0.0 2.7 0.9 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 2.6 0.0 1.2 0.0 0.1 1.3 0.0 4.4 0.0 0.0 0.1 0.0 2.7 0.0 0.0 0.1 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.4 36.2 0.0 1.4 0.3 1.6 0.1 0.0 6.7 0.3 2.3 3.0 0.6 0.1 3.0 0.0 0.0 0.0 8.3 0.1 0.0 0.1 0.3 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.1 0.0 2.3 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.1 1.0 4.7 7.8 2.9 1.1 0.9 4.2 1.5 4.7 0.2 3.0 0.0 0.1 0.0 1.5 1.3 5.3 0.0 3.9 3.7 0.0 0.3 0.7 0.9 17.1 0.0 3.0 5.5 0.0 0.0 0.4 0.5 0.0 2.3 5.8 2.6 0.7 0.1 6.0 2.7 0.4 4.4 0.0 1.4 4.1 2.8 0.0 3.0 0.0 0.1 0.1 0.0 0.9 3.0 2.0 0.0 0.0 9.9 0.9 0.1 0.0 0.0 0.1 0.0 3.1 1.0 0.0 1.8 0.0 0.0 0.0 2.0 0.1 0.3 1.8 0.5 0.0 1.0 0.3 0.2 0.4 0.0 0.0 0.0 0.4 0.1 0.4 1.2 DPAGT1 "ALG7, CDG-Ij, D11S366, DGPT, DPAGT, DPAGT2, GPT" ENSG00000172269 "Dolichyl-phosphate N-acetylglucosaminephosphotransferase 1" Q9H3H5 11 119096503-119108331 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation, Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA053878 Approved NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 29: Non-specific - Vesicular transport" "Cluster 1: K-562 - Erythropoiesis" "Cluster 55: Plasma cells - Humoral immune response" "HPA053878: AB_2682288" "unprognostic (1.66e-2)" "unprognostic (3.14e-3)" "unprognostic (1.76e-1)" "unprognostic (7.83e-3)" "unprognostic (6.50e-2)" "unprognostic (8.53e-3)" "prognostic unfavorable (2.03e-5)" "unprognostic (2.52e-1)" "unprognostic (3.95e-1)" "unprognostic (9.05e-2)" "unprognostic (2.08e-2)" "unprognostic (7.12e-2)" "unprognostic (2.19e-3)" "unprognostic (1.87e-3)" "unprognostic (1.08e-2)" "unprognostic (2.52e-2)" "unprognostic (4.57e-2)" 11.3 14.1 13.0 13.7 13.3 9.1 14.8 13.9 22.4 16.1 17.6 17.7 16.8 10.2 21.8 12.4 17.3 14.5 8.6 13.5 14.1 12.8 21.2 11.4 11.5 14.2 14.4 9.0 27.1 18.6 4.4 15.8 14.2 14.3 20.0 7.4 27.8 16.3 5.6 9.0 14.9 17.7 13.4 9.8 14.4 4.8 14.6 8.2 15.5 8.5 14.3 16.8 6.2 14.9 22.0 39.2 22.2 55.7 60.0 37.0 24.6 33.7 38.3 25.7 32.2 43.4 88.3 41.5 62.8 45.4 57.7 77.1 42.0 60.7 31.1 29.4 23.8 83.5 14.1 51.6 50.7 53.9 47.4 40.3 48.7 62.4 85.3 29.9 53.3 25.2 51.7 84.1 50.9 67.7 19.5 39.9 22.5 148.3 49.4 26.2 26.6 61.3 60.3 44.7 23.0 30.1 30.7 99.3 17.1 32.3 116.8 19.4 29.1 57.3 24.5 30.3 23.7 19.6 32.2 13.9 14.3 68.3 48.9 28.4 35.7 4.4 25.2 35.5 28.4 24.5 20.1 24.8 43.3 25.6 16.6 15.8 3.0 20.7 32.7 37.5 19.6 20.2 13.0 13.3 13.9 22.4 13.5 14.1 14.2 14.4 14.2 13.4 14.6 14.9 11.5 6.4 8.1 7.2 10.7 13.3 15.2 34.4 13.1 6.1 18.4 12.1 5.0 14.3 22.8 14.7 14.6 34.2 9.6 10.3 3.9 32.9 0.9 15.6 12.3 16.0 10.2 8.6 7.3 13.3 44.4 11.0 14.3 11.2 12.7 12.7 15.7 23.1 28.8 3.3 5.7 19.8 32.6 13.0 11.4 1.9 14.0 14.1 8.8 5.6 20.9 6.2 13.4 7.5 5.4 13.9 11.1 8.2 33.2 14.5 19.3 11.3 37.2 4.6 0.0 6.0 10.7 6.8 10.3 14.1 12.5 23.5 10.0 15.9 20.7 12.9 DRAM2 "MGC54289, PRO180, RP5-1180E21.1, TMEM77, WWFQ154" ENSG00000156171 "DNA damage regulated autophagy modulator 2" Q6UX65 1 111117163-111140203 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Apoptosis, Autophagy" "Cone-rod dystrophy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018036, HPA061701" Supported Enhanced "Golgi apparatus,Vesicles" NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 16: Immune cells - Immune response" "Cluster 43: THP-1 - Innate immune response" "Cluster 57: B-cells - Immune response" "Golgi apparatus, Vesicles" "HPA018036: AB_1858134, HPA061701: AB_2684590" "unprognostic (9.38e-3)" "unprognostic (1.58e-2)" "unprognostic (2.16e-3)" "unprognostic (5.22e-2)" "unprognostic (1.12e-2)" "unprognostic (2.65e-2)" "prognostic unfavorable (3.45e-5)" "unprognostic (6.57e-3)" "prognostic unfavorable (6.43e-4)" "unprognostic (2.69e-1)" "unprognostic (4.37e-3)" "unprognostic (2.66e-1)" "prognostic unfavorable (7.45e-4)" "unprognostic (1.10e-1)" "unprognostic (1.63e-1)" "unprognostic (2.29e-1)" "unprognostic (1.77e-3)" 38.0 23.1 13.9 33.1 14.5 17.9 26.8 17.7 19.9 23.1 22.7 26.7 28.6 17.7 17.6 15.0 30.1 36.4 23.7 13.5 15.2 26.5 24.9 25.0 55.3 15.6 14.9 24.3 25.6 28.3 4.6 41.2 16.2 17.8 30.7 16.9 25.8 16.7 16.6 17.9 26.3 17.0 15.5 45.3 23.4 10.3 15.0 27.8 22.0 23.6 50.3 29.4 4.2 17.8 38.0 12.9 24.0 10.8 57.3 56.2 23.4 28.7 29.9 24.7 24.9 12.5 38.2 28.7 17.2 25.6 12.1 37.4 30.5 24.0 31.9 26.8 25.6 16.8 18.4 16.4 41.4 19.4 15.4 38.5 41.4 18.3 38.4 53.6 29.9 29.1 34.1 19.6 30.1 19.6 16.6 28.8 14.5 43.3 13.2 11.1 40.0 14.0 42.5 25.8 19.1 18.2 16.8 52.4 80.1 33.1 16.7 84.6 24.8 20.6 13.8 16.2 18.9 25.7 9.6 29.8 33.4 34.7 29.6 41.7 47.3 11.5 14.2 61.0 19.4 65.7 17.5 15.3 45.1 54.1 22.3 19.0 7.2 25.0 49.8 28.6 17.7 35.5 13.9 14.5 17.7 19.9 13.5 15.2 15.6 14.9 16.2 15.5 15.0 17.8 34.5 12.8 12.0 17.3 146.2 47.0 54.4 82.5 34.1 11.6 53.6 43.9 29.7 32.9 53.1 44.1 2.1 98.1 38.9 41.2 43.0 59.2 8.5 51.7 19.5 36.4 13.2 28.6 20.6 46.6 102.3 39.2 24.5 17.6 23.6 18.5 42.8 26.0 183.1 20.2 31.7 45.7 77.3 189.4 97.8 7.8 33.5 110.3 81.8 39.4 89.0 27.1 56.7 31.7 42.6 41.9 64.3 24.8 54.7 46.3 88.4 80.4 95.8 10.1 39.5 26.4 32.5 4.7 14.6 40.8 53.0 73.3 38.6 26.3 43.7 70.1 DRD3 ENSG00000151577 "Dopamine receptor D3" P35462 3 114127580-114199407 "Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins, Transporters" "G-protein coupled receptor, Receptor, Transducer" "FDA approved drug targets, Schizophrenia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 8 "brain: 5.6" "Group enriched" "Detected in some" 12 "Early spermatids: 6.2;Late spermatids: 19.6" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "basal ganglia: 5.6;cerebral cortex: 2.8;hypothalamus: 4.1" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in some" 5 "basal ganglia: 7.4" "Region enriched" "Detected in many" 10 "basal ganglia: 17.9" NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 65: Brain - Ion transport" "Cluster 25: Spermatids - Spermatogenesis" "unprognostic (2.32e-1)" 0.0 0.0 0.3 0.0 5.6 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 4.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.7 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.3 5.6 0.0 2.8 0.1 4.1 0.0 0.2 0.5 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.2 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 19.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 DSPP "DFNA39, DGI1, DMP3" ENSG00000152591 "Dentin sialophosphoprotein" Q9NZW4 4 87608529-87616873 "Disease related genes, Human disease related genes, Predicted secreted proteins" Biomineralization "Deafness, Disease variant" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA036230 Uncertain "Secreted in other tissues" NA NA 27000 "HPA036230: AB_10672239" "unprognostic (2.34e-1)" "unprognostic (1.08e-2)" "unprognostic (3.01e-1)" "unprognostic (1.27e-1)" "unprognostic (2.21e-2)" "unprognostic (1.26e-1)" "unprognostic (1.76e-1)" 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 DST "BP240, BPA, BPAG1, CATX-15, FLJ13425, FLJ21489, FLJ30627, FLJ32235, KIAA0728, MACF2" ENSG00000151914 Dystonin Q03001 6 56457987-56954830 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cell adhesion" "Actin-binding, Muscle protein" "Cancer-related genes, Epidermolysis bullosa, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Basal keratinocytes: 2368.6;Basal prostatic cells: 1651.4;Basal squamous epithelial cells: 3008.4;Cone photoreceptor cells: 1401.1;Oligodendrocytes: 1410.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "plasmacytoid DC: 1.3" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "hTCEpi: 488.1;hTERT-HME1: 371.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030200 Uncertain Approved Nucleoplasm,Microtubules,Cytosol NA NA 16000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 57: Non-specific - Angiogenesis" "Cluster 30: Epithelial cell lines - Translation" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Microtubules" Cytosol "HPA030200: AB_10601901" "unprognostic (4.87e-3)" "unprognostic (1.29e-1)" "unprognostic (3.40e-1)" "unprognostic (1.54e-1)" "unprognostic (1.25e-2)" "unprognostic (3.60e-2)" "unprognostic (5.78e-2)" "unprognostic (2.35e-2)" "unprognostic (1.09e-1)" "unprognostic (2.75e-2)" "unprognostic (1.13e-1)" "unprognostic (3.69e-1)" "unprognostic (4.39e-2)" "unprognostic (5.13e-3)" "unprognostic (1.46e-1)" "unprognostic (2.66e-1)" "unprognostic (7.62e-2)" 60.9 86.2 206.5 16.2 275.8 3.3 117.3 240.6 221.9 158.8 143.3 173.2 25.4 167.1 38.2 66.1 103.9 32.6 166.0 194.6 230.7 52.2 80.8 108.0 11.3 258.1 250.4 78.2 39.8 36.7 78.8 28.7 263.4 84.5 32.4 87.4 100.3 48.7 143.1 166.2 64.2 106.0 209.1 36.7 68.9 28.4 243.3 31.4 29.8 104.1 15.2 90.4 113.2 325.4 62.4 26.6 41.2 20.8 79.5 103.5 24.6 82.2 89.7 37.8 42.1 17.1 15.5 10.4 32.2 220.7 35.6 46.7 34.4 161.2 73.0 52.3 45.2 17.8 49.5 31.4 65.9 15.0 0.4 58.3 488.1 92.5 371.6 69.1 73.3 9.5 12.6 38.2 113.9 20.2 5.1 6.8 27.7 35.6 21.9 0.1 28.8 16.5 118.8 83.0 47.2 37.8 32.7 11.7 64.1 67.7 18.6 27.2 176.5 77.3 55.9 37.0 68.9 39.6 28.6 5.0 55.8 8.8 40.3 0.0 0.7 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.9 0.2 0.0 0.0 0.0 0.9 0.3 1.3 0.0 0.1 206.5 275.8 240.6 221.9 194.6 230.7 258.1 250.4 263.4 209.1 243.3 325.4 193.2 336.5 11.8 1048.7 5.6 2368.6 1651.4 250.1 3008.4 673.1 81.0 301.5 862.8 77.2 161.7 55.2 1401.1 61.5 7.8 357.8 7.9 204.3 53.6 133.8 218.4 122.7 44.9 12.4 550.4 66.3 11.6 212.5 71.9 166.8 17.1 478.7 60.7 80.3 21.8 307.9 591.7 100.3 118.0 74.2 124.6 15.5 133.3 56.6 215.3 215.5 46.6 200.8 2.1 630.3 1410.3 194.1 283.0 152.4 27.2 229.8 124.2 10.3 52.0 122.6 65.7 381.8 196.6 20.0 13.7 298.2 857.2 26.5 19.7 30.5 48.1 142.8 DSTYK "DustyPK, KIAA0472, RIP5, RIPK5, SPG23" ENSG00000133059 "Dual serine/threonine and tyrosine protein kinase" Q6XUX3 1 205142505-205211702 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Horizontal cells: 89.2;Melanocytes: 90.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044140 Approved NA NA "Cluster 34: Basophils - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 62: Horizontal cells - Visual perception" "HPA044140: AB_10965031" "unprognostic (1.42e-2)" "unprognostic (1.07e-2)" "unprognostic (7.92e-2)" "unprognostic (1.02e-3)" "unprognostic (1.39e-1)" "unprognostic (2.66e-1)" "unprognostic (1.43e-2)" "unprognostic (9.01e-2)" "unprognostic (1.81e-1)" "unprognostic (1.06e-1)" "unprognostic (2.25e-3)" "unprognostic (1.20e-1)" "unprognostic (3.26e-2)" "unprognostic (7.80e-2)" "unprognostic (1.93e-1)" "unprognostic (1.55e-1)" "prognostic unfavorable (8.73e-5)" 4.5 7.2 11.5 3.8 11.1 19.2 6.7 11.5 12.1 6.4 6.8 6.0 2.7 7.9 5.8 5.5 7.2 4.5 4.9 11.8 11.3 7.5 2.2 6.1 4.0 13.5 10.7 11.1 4.5 13.1 5.5 6.0 13.7 5.6 3.6 13.5 4.4 6.9 9.6 12.0 4.1 7.1 9.9 6.2 4.2 5.1 11.5 6.2 6.8 6.8 4.5 5.2 5.4 13.5 9.9 6.3 6.6 8.1 9.5 15.9 4.7 12.0 12.1 12.4 8.4 2.9 5.3 7.3 3.5 20.6 6.9 6.9 7.3 7.8 12.4 3.5 7.8 13.3 8.1 3.1 8.5 3.7 6.8 9.4 11.6 12.7 12.0 14.7 9.2 5.2 17.4 4.8 10.0 6.8 2.9 3.3 7.2 1.8 7.4 2.6 12.1 6.5 8.4 6.1 3.7 7.2 10.3 10.5 34.5 7.7 7.8 4.9 9.2 7.7 7.7 11.8 8.2 4.8 3.7 4.1 9.0 5.1 28.2 8.1 1.9 3.6 2.4 1.5 2.3 1.5 1.8 2.0 1.7 1.7 2.6 1.9 2.7 2.8 1.0 1.2 1.1 1.0 11.5 11.1 11.5 12.1 11.8 11.3 13.5 10.7 13.7 9.9 11.5 13.5 15.8 28.9 15.5 26.4 15.3 14.9 7.2 10.5 14.2 48.0 14.5 13.6 13.6 12.8 15.1 16.5 33.3 6.8 15.1 3.8 5.9 12.5 11.3 16.3 37.7 16.1 12.7 31.6 35.1 9.1 6.1 19.4 8.2 11.6 24.1 43.2 28.5 6.9 8.8 89.2 36.6 6.2 6.1 23.6 15.6 25.2 16.4 11.4 90.7 21.5 20.6 45.1 23.7 17.1 43.0 10.6 5.0 18.0 11.1 10.7 6.1 6.9 24.7 37.3 26.3 22.4 16.4 22.3 13.0 10.1 13.9 2.6 15.1 27.8 7.5 6.7 DYNC1H1 "CMT2O, DHC1, DNCH1, Dnchc1, DNCL, DNECL, HL-3, p22" ENSG00000197102 "Dynein cytoplasmic 1 heavy chain 1" Q14204 14 101964573-102056443 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Transport" "Motor protein" "Charcot-Marie-Tooth disease, Disease variant, Mental retardation, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003742, CAB010443" Enhanced Supported Centrosome,Cytosol NA NA 490000 "Cluster 11: Basophils - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 20: HeLa - Mitochondria" "Cluster 52: Non-specific - Transcription" "Centrosome, Cytosol" "CAB010443: AB_2093483, HPA003742: AB_1078713" "unprognostic (2.58e-1)" "unprognostic (6.77e-2)" "unprognostic (1.68e-1)" "unprognostic (4.65e-2)" "unprognostic (4.66e-2)" "unprognostic (5.49e-2)" "prognostic unfavorable (3.03e-7)" "unprognostic (8.93e-2)" "unprognostic (1.23e-2)" "unprognostic (1.92e-1)" "unprognostic (2.38e-1)" "unprognostic (2.31e-1)" "prognostic favorable (1.09e-6)" "unprognostic (1.63e-2)" "unprognostic (8.73e-2)" "unprognostic (1.93e-1)" "unprognostic (4.52e-3)" 22.4 19.3 7.8 4.9 7.2 9.2 18.2 16.1 10.9 17.2 0.0 29.1 3.6 24.6 5.0 18.5 17.5 4.0 29.7 9.2 1.1 12.6 9.4 19.9 4.4 5.2 4.3 21.0 15.8 2.0 20.9 3.0 9.0 14.5 3.1 13.2 19.9 2.9 53.1 27.6 19.2 3.1 0.6 14.2 19.7 13.0 2.1 2.0 17.6 1.2 2.4 23.4 18.0 9.2 3.3 6.6 5.0 4.6 3.0 5.0 3.2 3.0 1.8 5.1 4.5 2.6 4.5 4.2 3.4 5.4 4.9 4.0 8.2 5.3 3.6 3.4 3.5 4.1 15.1 3.3 2.7 3.6 6.4 6.4 6.3 14.1 4.9 3.2 3.9 8.0 3.0 8.9 4.5 4.2 5.6 4.1 5.1 2.1 10.2 4.6 3.3 1.6 5.2 7.6 8.4 2.8 3.2 2.2 3.4 4.9 2.5 1.5 11.5 6.8 4.1 11.5 5.1 4.3 7.6 4.9 9.1 2.9 3.0 1.3 0.6 0.8 0.6 0.4 0.5 0.4 0.4 0.4 0.6 0.5 0.3 0.5 1.2 0.4 0.6 0.6 0.4 0.3 7.8 7.2 16.1 10.9 9.2 1.1 5.2 4.3 9.0 0.6 2.1 9.2 102.1 125.0 84.7 83.9 55.9 52.4 46.4 75.0 51.2 126.4 63.1 55.5 182.9 31.5 89.1 77.3 139.7 49.6 106.3 94.2 13.7 112.6 14.8 123.6 131.0 93.7 71.3 38.1 127.3 81.2 42.9 86.5 86.6 134.6 33.5 117.9 46.1 36.7 40.2 183.4 131.0 68.0 75.3 52.7 123.6 16.8 70.5 90.7 71.2 51.5 99.2 63.3 73.2 51.8 93.3 131.3 73.6 71.5 100.0 47.6 82.6 48.5 90.7 115.4 85.5 81.4 106.1 87.1 72.2 59.2 64.1 37.4 91.3 86.1 64.4 46.5 EDN3 ET3 ENSG00000124205 "Endothelin 3" P14138 20 59300443-59325992 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" "Vasoactive, Vasoconstrictor" "Deafness, Disease variant, Hirschsprung disease, Waardenburg syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "cervix: 53.1;salivary gland: 68.3;vagina: 106.5" "Group enriched" "Detected in some" 4 "Basal squamous epithelial cells: 99.6;Distal enterocytes: 86.6;Paneth cells: 72.4;Proximal enterocytes: 93.0;Skeletal myocytes: 110.0;Squamous epithelial cells: 69.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "Secreted to blood" NA NA 30900 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 37: Intestine - Unknown function" "Cluster 45: Enterocytes - Digestion" "unprognostic (4.64e-3)" "unprognostic (7.87e-2)" "unprognostic (7.49e-2)" "unprognostic (2.88e-3)" "prognostic favorable (1.73e-4)" "unprognostic (1.58e-1)" "unprognostic (1.78e-2)" "unprognostic (1.06e-1)" "unprognostic (2.69e-1)" "unprognostic (4.01e-2)" "unprognostic (4.08e-2)" "unprognostic (4.48e-1)" "unprognostic (6.11e-2)" "unprognostic (1.55e-1)" "unprognostic (6.40e-2)" 0.1 2.3 4.9 2.0 5.1 0.0 7.8 4.8 5.9 53.1 3.3 20.2 42.0 5.2 6.1 20.6 0.2 0.4 0.1 4.9 4.5 0.2 0.0 0.4 0.2 5.5 7.3 1.3 8.8 0.3 44.7 0.2 8.6 5.6 18.8 2.0 68.3 0.5 1.5 1.9 40.6 3.0 5.0 7.9 1.7 1.2 11.2 3.2 24.2 2.4 0.1 0.1 106.5 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 4.9 5.1 4.8 5.9 4.9 4.5 5.5 7.3 8.6 5.0 11.2 3.9 0.1 9.6 0.5 0.0 0.0 0.4 5.1 0.0 99.6 0.1 1.7 21.0 0.2 0.0 0.0 0.0 0.0 0.1 0.1 86.6 0.0 0.3 0.0 1.6 11.2 0.4 1.2 0.0 0.8 0.0 0.3 2.6 0.0 3.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 5.6 0.0 0.0 0.4 0.0 0.0 0.5 0.0 20.6 0.0 0.4 0.0 0.0 0.0 0.2 72.4 1.9 1.2 0.2 93.0 0.0 0.0 0.4 0.0 110.0 0.4 0.1 0.8 69.2 0.3 0.0 0.3 0.1 15.9 0.3 EEF1A2 "EEF1AL, HS1, STN, STNL" ENSG00000101210 "Eukaryotic translation elongation factor 1 alpha 2" Q05639 20 63488013-63499239 "Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Protein biosynthesis" "Elongation factor" "Autism spectrum disorder, Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "skeletal muscle: 1638.0" "Cell type enhanced" "Detected in many" "Bipolar cells: 130.8;Cardiomyocytes: 125.5;Horizontal cells: 269.2;Rod photoreceptor cells: 50.9;Skeletal myocytes: 49.9" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "cerebral cortex: 347.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HAP1: 240.0;MCF7: 405.9;SCLC-21H: 187.0;T-47d: 157.2;U-2 OS: 202.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034019, HPA051759, HPA053862, HPA056990" Approved Approved Nucleoli,Cytosol NA NA 55000000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 80: Striated muscle - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 37: Myocytes - Muscle contraction" Cytosol Nucleoli "CAB034019: AB_1562672, HPA051759: AB_2681595, HPA053862: AB_2797248, HPA056990: AB_2683302" "unprognostic (1.40e-2)" "unprognostic (6.82e-2)" "unprognostic (4.56e-2)" "prognostic unfavorable (2.90e-5)" "unprognostic (5.17e-2)" "prognostic unfavorable (9.11e-4)" "unprognostic (4.85e-1)" "unprognostic (1.68e-1)" "unprognostic (3.02e-2)" "unprognostic (1.74e-2)" "unprognostic (2.20e-2)" "unprognostic (2.30e-1)" "unprognostic (1.86e-1)" "unprognostic (8.29e-3)" "unprognostic (1.82e-1)" "unprognostic (1.36e-2)" "unprognostic (1.07e-1)" 0.9 32.7 59.3 1.4 81.3 0.0 1.7 17.1 347.2 2.8 0.0 5.1 0.7 0.3 1.1 9.7 0.4 2.4 358.0 73.4 97.3 1.3 3.0 0.8 0.6 95.0 2.9 0.5 6.5 16.2 111.5 0.0 76.3 9.6 0.4 37.2 19.5 0.8 1638.0 6.8 1.9 0.8 0.0 0.3 8.5 1.2 30.7 0.2 0.7 320.7 0.1 2.2 1.8 125.0 0.5 71.0 0.8 16.8 0.0 0.6 7.9 10.0 1.3 51.6 16.3 9.8 41.5 0.0 110.4 0.5 13.4 38.8 240.0 0.7 115.9 0.5 13.1 0.0 24.1 4.1 2.9 0.0 13.4 1.4 2.2 0.1 1.0 0.2 0.0 0.0 3.4 0.2 0.5 405.9 1.4 0.5 11.4 95.6 96.5 8.0 0.2 10.2 2.4 3.9 187.0 89.9 90.0 12.6 1.6 2.2 157.2 3.8 0.0 0.3 202.9 0.7 1.8 0.3 0.9 1.4 0.9 0.5 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 59.3 81.3 17.1 347.2 73.4 97.3 95.0 2.9 76.3 0.0 30.7 125.0 0.1 0.0 0.0 9.4 0.7 0.4 0.9 0.0 0.0 130.8 11.8 4.6 125.5 1.5 0.6 0.0 12.5 0.0 1.1 0.4 0.0 1.3 0.2 0.5 0.3 2.2 0.0 0.0 35.5 0.2 0.2 3.6 4.6 1.4 5.7 1.0 1.1 0.1 0.0 269.2 37.2 0.0 0.0 0.3 0.7 0.5 0.0 0.6 0.0 15.0 0.0 11.7 0.0 14.6 12.7 0.3 0.0 0.0 0.3 2.6 0.0 0.5 0.0 50.9 0.0 49.9 3.4 0.0 0.3 0.0 1.8 0.0 1.5 0.0 0.5 1.1 EEF2 "EEF-2, EF2" ENSG00000167658 "Eukaryotic translation elongation factor 2" P13639 19 3976056-3985463 "Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Protein biosynthesis" "Elongation factor" "Cancer-related genes, Disease variant, FDA approved drug targets, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007795, HPA040534, HPA057351" Enhanced Enhanced "Plasma membrane,Cytosol" NA NA 17000000 "Cluster 30: Non-specific - Translation" "Cluster 50: Non-specific - Ribosome" "Cluster 30: Epithelial cell lines - Translation" "Cluster 32: Non-specific - Translation" "Plasma membrane, Cytosol" "CAB007795: AB_598149, HPA040534: AB_2677024, HPA057351: AB_2683417" "unprognostic (5.47e-2)" "unprognostic (9.59e-2)" "unprognostic (3.75e-1)" "prognostic favorable (1.81e-6)" "unprognostic (2.06e-2)" "unprognostic (3.26e-1)" "unprognostic (1.53e-2)" "unprognostic (2.11e-1)" "unprognostic (1.83e-1)" "unprognostic (1.77e-2)" "unprognostic (1.25e-2)" "unprognostic (1.42e-1)" "prognostic favorable (1.25e-5)" "unprognostic (4.46e-2)" "unprognostic (5.60e-2)" "unprognostic (6.82e-2)" "unprognostic (9.86e-2)" 1022.6 1037.0 771.8 507.3 755.2 920.3 946.7 737.2 1059.6 966.7 807.6 1122.4 821.4 887.6 563.7 1062.3 857.3 501.2 1396.6 740.9 729.1 843.2 1152.9 666.9 685.4 775.4 769.6 1627.6 3194.1 494.0 838.0 386.2 782.3 819.2 344.5 224.7 1276.4 500.3 2322.6 1142.7 798.9 385.4 758.3 721.6 1266.6 490.5 762.7 541.0 793.6 1112.4 499.0 927.8 797.7 745.1 1456.8 1018.4 579.3 1539.4 1515.6 2706.7 830.9 1110.4 1479.8 1036.7 1012.7 1618.1 652.7 3000.6 644.1 1032.3 461.1 1069.8 919.4 1719.4 544.2 755.0 1533.0 768.5 919.9 1677.0 2204.8 1668.0 1277.6 3515.5 1777.2 916.0 1404.1 1497.5 1086.6 1434.4 1526.7 2145.4 642.1 2095.7 1510.1 1266.3 1537.0 518.3 1015.7 1654.2 860.3 1938.3 871.2 1270.2 1575.4 1466.4 699.0 1377.1 2058.3 543.1 1344.7 1992.7 1321.8 738.2 765.7 1521.4 1738.7 2276.4 1644.3 1485.3 1100.4 2065.8 986.6 81.2 455.7 64.1 259.8 333.1 460.2 578.5 453.0 344.6 430.7 478.1 497.2 404.1 43.1 355.3 342.1 358.7 429.4 756.5 771.8 755.2 737.2 1059.6 740.9 729.1 775.4 769.6 782.3 758.3 762.7 745.1 323.1 221.2 392.2 24.5 1125.5 1321.1 1071.3 754.3 1269.7 212.6 981.3 694.3 627.9 597.7 448.3 255.6 77.2 958.1 535.9 556.9 986.1 716.0 799.2 318.2 675.4 568.2 744.2 934.8 23.2 1816.8 1305.0 679.7 619.3 428.5 373.4 596.1 656.8 690.6 610.1 203.6 28.9 982.1 411.0 885.4 859.5 1195.6 1008.4 514.2 645.7 36.5 907.5 429.1 614.8 27.2 42.2 868.2 815.5 832.8 992.8 1010.5 1562.7 1078.8 194.5 134.1 585.1 797.7 697.3 371.5 308.4 1343.0 1347.1 1243.1 727.1 1044.3 1168.4 1051.6 EFEMP1 "DHRD, FBLN3, FBNL, MTLV, S1-5" ENSG00000115380 "EGF containing fibulin extracellular matrix protein 1" Q12805 2 55865967-55924139 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Growth factor" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 367.7;Cytotrophoblasts: 1365.8;Fibroblasts: 309.7;Syncytiotrophoblasts: 889.6" "Cancer enhanced" "Detected in all" "glioma: 94.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HSkMC: 953.6;hTERT-RPE1: 2226.5;HUVEC TERT2: 4270.9;TIME: 3554.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB016368, HPA049806, HPA070841, HPA071588" Supported Supported Mitochondria "Secreted to extracellular matrix" NA NA 1900000000 "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 47: Cytotrophoblasts - Unknown function" Mitochondria "CAB016368: AB_2277777, HPA049806: , HPA070841: AB_2686319, HPA071588: " "unprognostic (8.21e-2)" "unprognostic (7.68e-2)" "unprognostic (9.01e-3)" "prognostic unfavorable (4.72e-4)" "unprognostic (3.43e-2)" "unprognostic (1.73e-2)" "unprognostic (4.86e-2)" "unprognostic (1.38e-1)" "unprognostic (3.46e-1)" "unprognostic (9.07e-2)" "unprognostic (1.55e-2)" "unprognostic (1.50e-1)" "prognostic unfavorable (3.89e-8)" "unprognostic (3.15e-3)" "unprognostic (4.94e-2)" "unprognostic (3.09e-1)" "prognostic unfavorable (6.68e-5)" 240.5 55.7 57.0 57.2 82.8 0.2 115.3 57.1 88.8 54.9 180.7 74.6 22.5 73.2 128.4 51.5 134.8 140.4 187.8 47.5 75.6 57.4 12.9 150.1 27.2 80.8 121.1 175.1 29.2 17.6 22.6 329.7 65.5 58.4 91.0 42.8 87.7 161.2 14.7 55.2 45.3 93.5 72.2 42.4 46.9 8.0 71.0 16.8 139.1 93.8 21.2 203.9 77.3 71.9 358.4 3.1 8.5 0.3 320.9 217.1 0.8 208.1 233.7 25.2 20.5 0.0 18.0 0.5 140.4 234.3 22.1 323.4 1.6 234.6 8.9 1.0 1.0 0.3 87.4 0.2 843.2 0.3 0.6 953.6 117.5 21.9 260.9 2226.5 4270.9 0.5 1.2 0.2 99.2 36.7 2.6 0.5 4.2 0.1 0.8 0.2 0.3 0.9 9.8 7.3 2.0 0.4 284.6 105.0 0.7 8.1 289.8 1.5 3554.3 1.5 107.5 397.9 138.5 13.7 0.5 1.4 73.1 0.3 6.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 57.0 82.8 57.1 88.8 47.5 75.6 80.8 121.1 65.5 72.2 71.0 71.9 26.6 250.0 109.1 234.1 0.1 79.4 79.1 367.7 42.1 2.8 6.2 78.2 12.5 12.8 98.2 27.6 0.0 1365.8 0.4 0.0 9.8 36.2 0.5 2.2 38.9 73.5 0.0 0.0 1.0 25.6 173.0 309.7 6.1 2.1 2.5 3.9 48.5 0.7 94.9 0.0 4.7 0.0 40.7 0.8 33.9 0.9 42.6 3.2 17.8 6.5 0.6 137.3 0.0 2.5 0.8 2.8 0.0 0.0 1.5 24.2 0.0 14.7 88.8 4.7 0.0 7.0 28.7 0.4 1.8 6.0 31.7 889.6 5.0 61.3 0.0 6.2 EFHC1 "EJM, EJM1, FLJ10466, POC9, RIB72" ENSG00000096093 "EF-hand domain containing 1" Q5JVL4 6 52362123-52529886 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "fallopian tube: 34.6" "Cell type enhanced" "Detected in many" "Early spermatids: 242.0;Endometrial ciliated cells: 227.5;Respiratory ciliated cells: 529.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "plasmacytoid DC: 6.1" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "hTERT-RPE1: 25.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA035307 Approved NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 49: Ciliated cells - Cilium organization" "HPA035307: AB_2674561" "unprognostic (2.11e-1)" "unprognostic (5.22e-2)" "unprognostic (3.31e-1)" "unprognostic (3.43e-2)" "unprognostic (2.51e-1)" "unprognostic (4.03e-3)" "unprognostic (1.60e-4)" "unprognostic (2.53e-2)" "unprognostic (1.18e-1)" "unprognostic (1.44e-1)" "prognostic favorable (2.33e-4)" "unprognostic (3.04e-1)" "prognostic unfavorable (3.29e-4)" "unprognostic (5.83e-2)" "unprognostic (3.14e-1)" "unprognostic (6.53e-2)" "unprognostic (3.27e-1)" 4.4 3.9 4.4 1.9 6.6 3.6 5.4 4.9 5.8 8.8 24.6 5.4 2.1 6.8 6.7 3.3 34.6 3.6 3.8 4.4 4.5 5.6 2.5 6.5 2.4 8.1 8.3 7.3 4.5 5.6 15.5 3.6 5.2 5.6 3.3 21.7 5.1 3.8 2.1 5.7 3.9 3.4 5.6 3.4 4.2 17.6 5.2 2.0 9.3 1.3 2.0 4.7 5.4 6.7 3.5 3.9 9.3 6.4 9.0 15.3 1.8 4.1 10.6 5.5 8.6 2.4 4.1 1.5 9.0 6.8 10.5 3.6 2.7 7.6 7.1 0.8 3.3 1.4 11.0 3.3 6.2 1.5 1.6 7.3 4.2 7.8 7.2 25.9 11.7 1.7 3.1 2.4 8.4 3.1 1.7 2.3 2.8 2.7 1.5 2.3 5.1 1.9 7.4 1.3 18.5 5.2 1.0 1.8 8.4 11.8 6.5 1.6 3.8 4.0 5.3 1.5 3.2 2.1 2.8 2.7 11.2 0.5 7.3 0.7 0.6 1.5 0.7 0.2 0.3 3.8 0.3 0.6 1.4 3.9 0.3 0.6 2.0 1.5 0.3 6.1 0.2 0.4 4.4 6.6 4.9 5.8 4.4 4.5 8.1 8.3 5.2 5.6 5.2 6.7 14.5 6.4 14.9 32.7 24.2 18.1 36.0 49.5 53.5 23.1 31.3 19.2 4.5 17.2 44.7 42.3 60.5 12.6 10.2 9.9 0.0 18.8 242.0 227.5 19.0 15.0 25.0 6.5 25.6 8.0 17.8 27.1 14.3 15.3 8.2 22.6 17.5 5.6 7.8 13.5 26.3 14.9 69.2 10.6 14.5 73.8 28.3 6.9 16.0 14.0 8.8 10.9 20.6 22.1 23.8 11.0 15.9 22.2 13.8 17.4 24.8 6.9 529.7 47.5 32.9 29.3 21.3 93.5 22.8 13.2 12.1 4.5 9.0 28.8 10.1 27.8 EGR2 KROX20 ENSG00000122877 "Early growth response 2" P11161 10 62811996-62919900 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, DNA-binding, Transferase" "Charcot-Marie-Tooth disease, Dejerine-Sottas syndrome, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "epididymis: 59.9;thyroid gland: 136.4" "Cell type enhanced" "Detected in many" "Breast glandular cells: 55.5;Breast myoepithelial cells: 68.1;Enteroendocrine cells: 73.1" "Cancer enhanced" "Detected in all" "thyroid cancer: 19.7" "Group enriched" "Detected in many" 5 "cerebral cortex: 10.2;hippocampal formation: 5.2" "Immune cell enhanced" "Detected in some" "intermediate monocyte: 2.5;non-classical monocyte: 2.3" "Low lineage specificity" "Detected in single" "Cell line enriched" "Detected in some" 5 "U-87 MG: 22.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA031165 Supported Nucleoplasm NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "HPA031165: AB_2673768" "prognostic favorable (7.30e-5)" "unprognostic (1.86e-3)" "unprognostic (1.45e-2)" "unprognostic (8.72e-2)" "unprognostic (2.92e-2)" "unprognostic (1.29e-1)" "unprognostic (2.70e-1)" "unprognostic (1.75e-1)" "unprognostic (9.79e-2)" "unprognostic (1.15e-1)" "unprognostic (1.18e-1)" "unprognostic (1.27e-1)" "unprognostic (2.47e-3)" "unprognostic (6.54e-2)" "unprognostic (1.74e-2)" "unprognostic (3.46e-1)" "unprognostic (1.11e-3)" 13.7 10.6 0.4 9.8 1.2 8.2 8.6 1.3 10.2 18.5 2.0 3.3 1.9 6.0 59.9 8.8 4.5 31.9 14.9 5.2 0.2 7.9 5.4 15.2 14.4 0.3 0.3 9.4 4.2 7.0 8.7 3.0 0.7 17.5 3.7 1.4 2.9 1.9 0.9 14.2 4.6 16.8 0.1 4.5 2.3 4.1 0.6 26.4 136.4 9.1 7.1 15.7 1.7 1.5 0.0 0.2 2.5 1.0 1.8 2.4 0.4 0.5 0.2 0.6 0.8 0.0 0.3 0.6 0.0 0.6 0.7 0.3 0.2 0.0 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.6 3.8 0.3 0.6 1.3 0.2 0.8 0.1 0.3 0.2 0.8 0.1 1.2 0.0 1.8 0.2 0.1 1.1 0.1 0.3 0.4 0.0 0.2 0.1 0.3 0.2 0.5 4.2 0.5 0.0 0.5 0.1 0.5 0.4 0.2 0.3 1.3 0.7 0.3 22.5 0.5 0.4 0.0 0.5 0.2 0.1 2.5 0.0 0.4 0.0 0.1 0.5 0.4 0.0 0.1 0.7 0.2 2.3 0.0 0.0 0.4 0.4 1.2 1.3 10.2 5.2 0.2 0.3 0.3 0.7 0.1 0.6 1.5 15.9 0.0 12.6 0.0 14.0 21.3 30.1 36.0 33.0 1.4 55.5 68.1 7.8 0.0 9.4 0.0 0.0 1.1 9.9 9.5 0.0 1.4 8.9 13.9 14.0 16.7 73.1 0.0 1.7 0.6 1.6 30.4 13.3 26.1 20.8 2.3 5.3 2.4 25.2 0.0 0.5 29.4 14.2 28.1 39.5 4.3 1.8 40.5 8.8 0.0 0.8 4.1 0.0 0.0 0.1 1.0 4.4 7.2 6.4 5.5 7.7 0.0 7.1 0.7 6.6 20.7 12.0 0.1 2.0 14.8 12.5 1.1 13.6 5.1 25.8 3.1 EIF2AK1 "HRI, KIAA1369" ENSG00000086232 "Eukaryotic translation initiation factor 2 alpha kinase 1" Q9BQI3 7 6022247-6059175 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Protein synthesis inhibitor, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Cytotrophoblasts: 219.1;Erythroid cells: 422.0;Syncytiotrophoblasts: 371.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016496, CAB022082, HPA061675" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 6: Erythroid cells - Oxygen transport" Nucleoplasm Cytosol "CAB022082: , HPA016496: AB_1848057, HPA061675: AB_2684583" "unprognostic (7.15e-3)" "unprognostic (2.00e-2)" "unprognostic (1.45e-1)" "unprognostic (2.91e-1)" "unprognostic (6.70e-2)" "unprognostic (9.69e-3)" "prognostic unfavorable (6.99e-4)" "unprognostic (2.36e-1)" "unprognostic (2.54e-1)" "unprognostic (1.07e-2)" "unprognostic (1.48e-1)" "unprognostic (8.96e-2)" "unprognostic (2.53e-1)" "unprognostic (1.99e-1)" "unprognostic (5.45e-2)" "unprognostic (9.02e-2)" "unprognostic (1.06e-2)" 27.2 39.4 28.1 27.7 28.9 105.9 35.9 30.6 36.1 29.0 34.9 48.8 37.1 25.0 37.4 30.4 31.0 23.8 33.8 28.1 30.6 43.8 65.1 30.3 35.2 30.5 28.9 29.3 44.3 78.0 25.9 52.3 31.6 35.0 47.3 29.0 46.8 24.2 38.3 33.3 37.2 23.8 29.1 26.6 49.1 19.5 29.8 43.6 39.3 34.4 40.4 27.2 22.4 33.7 144.5 90.5 71.2 108.8 66.4 59.6 92.4 73.0 66.8 64.2 80.8 83.7 96.2 112.5 77.4 81.3 115.5 100.4 93.1 67.1 82.2 69.8 140.3 115.9 91.6 127.3 54.3 100.8 102.0 48.1 82.8 60.7 64.9 67.7 69.4 88.1 189.0 106.8 61.4 146.5 55.6 128.6 88.5 84.6 99.7 120.0 74.6 134.0 82.3 70.3 87.3 156.5 139.3 186.6 63.8 98.6 141.0 122.4 65.9 37.0 134.2 65.3 78.2 106.5 114.8 115.6 73.9 129.8 108.7 11.1 6.9 17.3 8.2 5.5 5.6 12.3 6.5 9.3 6.9 9.5 7.5 6.6 3.7 10.2 6.2 6.0 8.9 4.8 28.1 28.9 30.6 36.1 28.1 30.6 30.5 28.9 31.6 29.1 29.8 33.7 23.1 38.5 43.7 14.4 42.8 23.8 34.9 34.3 41.5 29.7 52.5 34.9 49.6 45.8 37.7 44.1 16.7 219.1 52.5 57.1 66.5 55.0 8.8 59.5 42.3 27.5 38.5 422.0 21.8 44.8 82.1 29.7 64.7 48.1 20.8 44.9 21.0 63.2 53.8 32.0 21.9 68.7 54.9 39.0 29.9 16.1 34.5 65.2 24.9 13.1 62.8 46.4 70.0 19.1 26.9 53.0 47.0 37.6 60.1 43.3 47.5 66.1 48.3 26.5 13.1 32.0 26.0 33.7 34.5 45.5 22.4 371.0 38.0 57.1 52.7 32.3 EIF2AK2 "EIF2AK1, PKR, PPP1R83, PRKR" ENSG00000055332 "Eukaryotic translation initiation factor 2 alpha kinase 2" P19525 2 37099210-37157522 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Antiviral defense, Host-virus interaction, Immunity, Innate immunity, Transcription, Transcription regulation" "Kinase, RNA-binding, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003845, HPA019795, HPA063893" Approved Enhanced Cytosol NA NA 44000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Cytosol "CAB003845: AB_562332, HPA019795: AB_1848060, HPA063893: AB_2685144" "unprognostic (1.70e-2)" "unprognostic (2.26e-1)" "unprognostic (1.62e-1)" "prognostic unfavorable (3.77e-4)" "unprognostic (1.66e-1)" "unprognostic (1.04e-1)" "unprognostic (1.77e-3)" "unprognostic (8.42e-2)" "unprognostic (8.02e-2)" "unprognostic (4.67e-2)" "prognostic unfavorable (2.08e-4)" "unprognostic (1.19e-1)" "unprognostic (3.15e-3)" "unprognostic (3.33e-1)" "unprognostic (1.74e-1)" "unprognostic (4.65e-2)" "unprognostic (5.32e-2)" 11.1 9.0 7.2 10.5 8.1 30.1 8.6 7.4 9.5 9.8 8.6 8.8 7.6 10.5 8.0 6.3 8.3 9.5 6.3 7.8 11.1 8.5 7.7 8.9 8.0 10.9 8.1 10.8 7.4 11.1 6.6 11.2 10.9 10.1 8.6 6.6 17.7 8.4 4.5 4.6 9.9 11.1 15.6 11.9 9.5 3.3 13.0 11.7 10.0 5.8 7.1 8.0 5.9 8.7 38.4 22.1 16.7 17.4 21.5 28.3 20.1 21.2 29.1 56.3 41.1 23.0 23.2 27.4 27.0 29.8 66.2 27.4 24.2 27.1 29.5 45.7 12.0 33.8 19.2 18.7 17.9 32.2 0.2 22.5 13.1 23.7 19.3 17.7 18.0 10.7 19.1 23.6 20.3 13.4 35.5 17.0 15.8 8.4 10.8 27.6 40.9 12.1 15.3 18.7 14.1 20.4 32.0 24.0 50.7 12.7 9.2 9.0 31.4 25.7 24.9 15.1 36.2 19.0 30.8 0.3 15.9 20.0 23.1 10.7 5.3 6.3 5.4 7.9 5.2 5.3 4.5 5.2 4.8 4.2 3.0 4.3 15.7 6.5 8.0 3.1 6.5 2.1 7.2 8.1 7.4 9.5 7.8 11.1 10.9 8.1 10.9 15.6 13.0 8.7 94.5 67.3 34.0 25.1 35.9 19.5 42.3 33.0 31.3 38.8 26.6 26.0 29.9 32.9 46.0 22.0 14.6 47.8 44.8 32.2 21.5 40.2 2.4 55.8 68.7 76.3 15.0 36.0 39.6 48.5 89.2 52.6 22.4 41.7 41.1 93.5 33.5 21.9 38.2 47.1 42.9 24.0 16.2 29.9 20.8 4.2 57.2 50.7 21.4 48.7 47.1 50.9 45.3 51.3 16.8 54.7 21.8 84.2 46.0 39.5 33.6 33.0 48.9 24.8 39.5 60.5 45.9 2.4 5.5 22.5 10.1 40.8 40.0 61.3 28.6 40.5 EIF2B1 "EIF-2B, EIF-2Balpha, EIF2B, EIF2BA" ENSG00000111361 "Eukaryotic translation initiation factor 2B subunit alpha" Q14232 12 123620406-123633766 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Protein biosynthesis" "Initiation factor" "Disease variant, Leukodystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034258, HPA049509" Approved Approved Cytosol NA NA 16000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 50: Non-specific - Ribosome" "Cluster 1: K-562 - Erythropoiesis" "Cluster 47: Cytotrophoblasts - Unknown function" Cytosol "CAB034258: AB_2095995, HPA049509: AB_2680797" "unprognostic (2.14e-2)" "unprognostic (4.18e-2)" "unprognostic (2.78e-1)" "unprognostic (7.50e-2)" "unprognostic (1.22e-1)" "unprognostic (7.21e-2)" "prognostic unfavorable (6.75e-7)" "unprognostic (5.65e-2)" "unprognostic (7.24e-3)" "unprognostic (1.53e-1)" "unprognostic (7.27e-2)" "unprognostic (1.94e-2)" "prognostic unfavorable (1.78e-9)" "unprognostic (2.46e-1)" "unprognostic (3.74e-2)" "unprognostic (1.09e-1)" "unprognostic (9.40e-2)" 32.9 32.1 23.5 33.0 25.7 36.4 31.5 27.8 27.9 33.1 23.9 33.2 27.6 34.0 29.5 33.8 31.1 22.0 26.3 24.8 23.7 28.7 29.0 24.4 40.4 25.4 23.8 34.1 32.9 21.7 28.2 31.0 27.4 29.4 30.8 23.5 28.8 26.2 43.1 51.1 29.2 31.5 23.9 33.4 28.7 22.6 25.7 30.0 27.4 27.3 43.1 32.5 31.2 32.2 55.6 47.9 50.0 53.1 45.8 46.2 52.5 66.8 38.2 64.3 46.7 62.8 34.0 104.2 77.3 51.1 28.6 54.3 79.0 52.0 67.3 85.4 87.8 74.9 68.3 55.6 43.3 106.9 90.2 42.0 63.3 55.4 38.9 54.0 59.6 66.8 136.4 34.2 60.2 50.4 86.1 113.3 82.4 59.5 64.1 89.5 61.1 79.2 43.2 46.0 61.9 69.9 49.4 48.7 63.3 46.7 88.5 63.2 56.8 43.8 52.9 63.2 62.4 90.9 102.1 153.6 63.6 71.7 63.9 113.2 87.3 119.3 56.3 104.2 51.3 60.1 57.2 58.9 95.7 53.2 58.0 53.9 9.8 64.8 101.6 59.9 73.2 100.7 23.5 25.7 27.8 27.9 24.8 23.7 25.4 23.8 27.4 23.9 25.7 32.2 29.0 16.0 19.6 10.7 29.3 20.4 17.5 28.3 24.5 19.8 16.0 17.3 20.0 25.8 19.0 18.4 8.4 69.0 33.8 18.3 29.4 33.0 7.6 15.0 28.3 26.0 21.7 21.9 23.4 40.1 58.8 23.6 15.3 14.2 41.2 24.4 22.1 13.1 37.8 16.8 21.2 15.4 18.3 18.6 18.5 5.3 25.1 26.0 19.6 14.0 30.6 34.4 35.0 16.1 21.9 32.8 23.8 16.6 30.7 14.8 26.1 23.9 14.3 21.6 32.9 18.5 29.8 49.2 38.7 27.3 20.5 51.6 26.7 29.3 21.7 14.6 EIF2B2 "EIF-2Bbeta, EIF2B" ENSG00000119718 "Eukaryotic translation initiation factor 2B subunit beta" P49770 14 75002921-75012366 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Protein biosynthesis" "Initiation factor" "Disease variant, Leukodystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 165.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005841, CAB037105, HPA048028" Enhanced Approved "Nucleoplasm,Plasma membrane,Focal adhesion sites" NA NA 12000 "Cluster 44: Non-specific - Transcription" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" "Plasma membrane, Focal adhesion sites" Nucleoplasm "CAB037105: AB_1840834, HPA005841: AB_1078725, HPA048028: AB_2680235" "unprognostic (1.10e-1)" "unprognostic (4.41e-2)" "unprognostic (5.70e-2)" "unprognostic (6.71e-2)" "unprognostic (7.64e-2)" "unprognostic (3.45e-3)" "prognostic unfavorable (2.26e-6)" "unprognostic (1.48e-1)" "unprognostic (1.23e-1)" "unprognostic (1.65e-2)" "unprognostic (4.95e-2)" "unprognostic (1.01e-1)" "prognostic favorable (2.95e-4)" "unprognostic (4.15e-2)" "unprognostic (2.74e-1)" "unprognostic (1.44e-1)" "unprognostic (3.28e-2)" 2.7 5.3 4.0 2.9 4.5 3.2 3.6 8.7 4.8 3.9 2.2 3.0 3.0 3.6 4.9 3.8 3.1 4.0 3.9 3.6 6.1 4.9 3.3 2.7 4.0 4.5 4.2 2.9 4.0 8.5 3.5 4.8 4.5 4.1 3.8 6.8 2.8 4.5 5.5 4.0 2.8 3.4 2.9 2.7 2.6 3.9 4.8 3.9 11.5 7.1 4.2 4.0 2.6 6.9 5.9 7.0 5.6 6.4 6.3 5.2 7.4 3.7 6.1 7.1 8.2 9.0 5.9 5.2 2.3 5.8 4.5 4.4 8.8 8.7 10.6 3.2 6.5 4.6 6.3 6.2 8.2 3.4 5.3 4.8 8.2 9.1 9.3 6.1 24.8 4.5 4.2 4.9 15.5 17.4 5.5 4.3 4.0 7.3 10.3 3.4 6.6 4.3 10.1 7.0 6.0 4.8 3.9 5.5 8.4 6.9 9.0 3.2 6.4 5.4 5.2 2.4 4.8 8.4 7.5 6.2 5.9 4.3 4.2 4.2 1.8 1.4 3.0 1.9 2.5 2.1 2.6 2.5 2.4 2.0 1.9 2.0 1.0 3.3 1.8 2.0 4.0 2.5 4.0 4.5 8.7 4.8 3.6 6.1 4.5 4.2 4.5 2.9 4.8 6.9 18.9 19.2 11.5 6.2 14.1 17.7 19.5 28.9 18.2 28.2 15.4 17.0 18.2 22.8 21.5 25.8 45.9 51.5 16.1 15.3 41.1 36.2 12.1 17.0 14.5 32.1 15.6 20.8 5.3 33.1 56.5 18.3 12.8 12.8 21.5 17.5 13.2 11.9 33.7 28.6 5.4 9.0 20.3 19.1 11.9 12.7 15.8 18.8 14.2 1.9 28.0 27.3 28.8 2.5 8.5 28.1 11.7 16.1 11.3 17.5 19.0 50.8 17.2 29.4 26.3 16.9 27.9 84.2 27.4 27.3 21.9 165.5 14.9 30.5 19.7 19.2 EIF2B3 "EIF-2B, EIF2Bgamma" ENSG00000070785 "Eukaryotic translation initiation factor 2B subunit gamma" Q9NR50 1 44850522-44986722 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Protein biosynthesis" "Initiation factor" "Disease variant, Leukodystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA024213, HPA024218, HPA024219" Supported Supported Vesicles,Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" "Vesicles, Cytosol" "HPA024213: AB_1848067, HPA024218: AB_1848068, HPA024219: AB_1848069" "unprognostic (2.12e-2)" "unprognostic (7.49e-2)" "unprognostic (4.37e-3)" "unprognostic (5.14e-2)" "unprognostic (1.57e-2)" "unprognostic (4.45e-2)" "prognostic unfavorable (1.73e-5)" "unprognostic (4.55e-2)" "unprognostic (1.14e-2)" "unprognostic (7.22e-2)" "unprognostic (2.16e-1)" "unprognostic (1.36e-1)" "unprognostic (5.38e-2)" "unprognostic (6.98e-2)" "unprognostic (7.80e-2)" "unprognostic (5.69e-3)" "unprognostic (2.73e-2)" 23.6 27.2 11.4 11.6 10.9 10.9 21.9 13.2 15.6 18.7 10.1 17.5 8.6 17.0 12.5 17.4 16.3 9.6 40.6 11.2 11.6 15.4 24.7 13.5 14.3 11.9 12.1 18.2 16.9 30.0 15.8 9.7 12.8 15.0 13.4 19.0 25.1 13.7 77.0 17.6 10.7 19.4 11.0 14.9 14.2 19.3 11.2 13.3 12.5 48.0 14.5 17.7 17.1 14.0 35.4 26.9 30.9 25.5 36.3 43.1 36.2 56.1 42.2 56.5 52.9 39.0 20.7 90.6 39.9 43.2 45.0 20.6 65.3 48.6 69.5 32.5 58.1 44.3 29.3 38.4 46.2 71.2 24.3 29.3 25.8 61.0 69.9 26.5 52.8 30.1 106.1 31.6 62.3 23.1 69.7 30.2 42.0 38.8 52.7 54.7 51.3 65.7 28.7 15.7 53.2 20.5 55.1 63.8 37.4 40.7 24.7 32.8 28.3 35.9 42.9 53.4 73.7 31.6 37.9 68.9 27.9 59.5 43.1 1.6 23.4 3.9 18.6 37.2 22.8 14.8 18.3 21.1 37.0 18.9 22.9 23.6 2.1 25.5 33.1 25.3 17.6 21.4 11.4 10.9 13.2 15.6 11.2 11.6 11.9 12.1 12.8 11.0 11.2 14.0 13.9 6.4 22.0 24.8 15.8 13.8 19.0 33.0 10.8 15.1 15.8 16.8 79.2 15.7 24.9 5.5 20.9 25.1 12.1 4.5 29.4 18.9 26.1 17.0 23.0 14.4 3.6 15.3 39.9 15.8 22.6 22.6 13.7 11.5 25.9 21.1 3.9 22.6 24.8 21.9 44.5 7.0 20.3 10.7 11.2 11.3 26.4 15.4 17.8 26.2 30.1 21.7 10.3 29.1 35.7 13.7 6.9 25.2 22.6 17.1 5.7 23.1 34.2 21.8 26.3 19.7 45.4 45.5 23.6 17.1 14.9 14.9 13.5 40.4 9.4 13.9 EIF2B4 "DKFZP586J0119, EIF-2B, EIF2B, EIF2Bdelta" ENSG00000115211 "Eukaryotic translation initiation factor 2B subunit delta" Q9UI10 2 27364352-27370457 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Protein biosynthesis" "Initiation factor" "Disease variant, Leukodystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 196.4;Late spermatids: 299.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032234, HPA039993, HPA068855" Approved Approved "Nuclear membrane,Actin filaments" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 31: Spermatids - Spermatogenesis" "Nuclear membrane" "Actin filaments" "CAB032234: AB_668909, HPA039993: AB_2676790, HPA068855: " "unprognostic (2.26e-2)" "unprognostic (1.41e-1)" "unprognostic (3.00e-1)" "unprognostic (7.55e-2)" "unprognostic (2.37e-1)" "unprognostic (4.63e-1)" "prognostic unfavorable (1.83e-4)" "unprognostic (3.64e-2)" "unprognostic (2.18e-1)" "unprognostic (3.56e-3)" "unprognostic (1.11e-1)" "unprognostic (2.68e-1)" "prognostic unfavorable (5.46e-8)" "unprognostic (1.79e-1)" "unprognostic (1.70e-1)" "unprognostic (8.76e-2)" "unprognostic (1.67e-2)" 21.4 24.8 23.3 15.2 24.3 10.7 20.7 24.0 23.8 21.3 22.5 31.7 14.6 21.0 16.9 27.8 20.3 13.4 28.0 23.2 23.7 18.2 21.5 18.1 17.2 24.4 24.3 19.8 31.4 20.4 20.3 18.8 24.0 25.4 18.4 19.3 24.6 20.8 51.8 29.3 18.4 22.8 23.2 18.6 24.7 38.1 24.4 18.9 18.1 35.2 22.9 24.1 21.4 24.1 38.7 59.8 44.3 34.6 58.4 42.7 48.4 41.0 43.7 55.7 37.3 89.2 16.9 49.7 38.7 48.7 46.6 27.6 62.5 50.8 36.2 37.4 40.7 61.7 39.3 104.5 51.1 58.2 23.0 41.3 51.1 69.2 51.6 40.4 53.3 37.2 59.5 24.9 53.0 35.2 28.8 61.7 49.1 59.8 38.9 52.9 69.9 43.2 50.0 32.7 34.3 37.4 34.1 53.8 42.6 39.6 31.3 23.4 52.8 40.1 47.0 35.4 49.7 50.9 65.7 74.7 33.9 47.9 38.6 56.6 53.9 38.8 32.1 48.1 44.6 31.1 31.6 32.6 52.5 25.3 30.2 32.9 7.7 30.8 52.2 38.6 43.8 43.2 23.3 24.3 24.0 23.8 23.2 23.7 24.4 24.3 24.0 23.2 24.4 24.1 19.9 12.8 14.8 9.8 17.5 35.9 18.9 32.0 15.4 22.6 28.0 18.7 33.0 14.3 27.0 22.0 66.7 40.9 27.8 23.4 19.6 29.0 196.4 22.3 23.9 19.9 24.0 8.2 6.6 33.4 25.0 24.6 14.8 17.6 31.6 16.9 25.7 34.4 24.3 10.1 6.5 24.8 28.5 20.7 28.0 299.6 23.3 16.5 23.2 2.8 29.5 23.2 16.5 6.0 8.8 26.7 27.1 24.8 28.4 21.2 23.0 27.6 24.9 58.9 19.7 17.0 34.9 71.5 38.9 14.5 34.8 46.1 24.3 23.8 20.5 14.4 EIF2B5 "EIF-2B, EIF2Bepsilon" ENSG00000145191 "Eukaryotic translation initiation factor 2B subunit epsilon" Q13144 3 184135038-184146127 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Protein biosynthesis" "Initiation factor" "Disease variant, Leukodystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB015412, HPA064370, HPA069303" Approved Enhanced Cytosol NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 59: Non-specific - Translation" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 39: Non-specific - Basic cellular processes" Cytosol "CAB015412: AB_831253, HPA064370: AB_2685249, HPA069303: AB_2686114" "unprognostic (3.28e-1)" "unprognostic (1.14e-2)" "unprognostic (9.05e-3)" "unprognostic (3.33e-2)" "unprognostic (1.15e-2)" "unprognostic (9.33e-2)" "prognostic unfavorable (3.38e-8)" "unprognostic (8.07e-2)" "unprognostic (1.32e-1)" "unprognostic (5.21e-2)" "unprognostic (3.80e-1)" "unprognostic (1.32e-2)" "unprognostic (9.97e-3)" "unprognostic (1.82e-1)" "unprognostic (1.01e-1)" "unprognostic (1.24e-1)" "unprognostic (5.32e-2)" 16.1 18.9 10.1 8.2 10.1 5.3 17.6 11.2 12.5 17.2 13.0 19.6 9.4 15.3 5.6 24.7 14.9 6.5 22.3 9.8 11.7 15.5 20.1 15.8 9.7 11.2 10.1 14.9 19.0 22.1 18.0 11.8 10.6 18.1 13.8 2.3 23.9 11.2 53.9 24.7 19.4 11.6 10.9 20.3 21.0 10.1 10.8 18.2 16.7 33.6 19.0 18.8 19.6 9.3 60.7 25.4 24.3 25.4 32.4 23.4 28.0 29.1 36.2 51.7 42.4 41.5 24.5 48.6 37.8 32.5 65.0 34.7 56.6 39.1 47.7 39.7 55.4 75.6 28.4 42.4 24.8 61.8 32.9 19.6 32.1 28.7 24.1 19.5 37.3 49.7 46.7 29.2 35.2 49.5 49.5 34.3 39.9 76.1 49.3 45.1 37.6 61.3 43.1 38.6 35.2 34.2 27.9 91.9 41.5 20.3 83.6 60.8 33.6 22.9 35.4 28.5 62.7 24.3 61.2 69.6 33.0 58.8 35.2 9.5 10.0 14.7 8.7 9.1 11.5 15.4 12.2 13.3 11.8 16.9 18.1 11.5 1.3 14.3 9.8 5.1 11.6 7.6 10.1 10.1 11.2 12.5 9.8 11.7 11.2 10.1 10.6 10.9 10.8 9.3 19.8 25.6 22.7 8.8 31.6 30.8 36.6 18.2 29.6 18.5 33.1 30.1 25.8 17.2 28.4 36.8 8.4 39.3 25.4 32.0 52.8 27.5 3.7 20.5 17.7 24.0 45.9 27.6 14.6 36.0 28.8 17.8 35.2 23.3 16.5 21.3 13.6 27.1 24.9 35.3 18.6 28.0 24.4 18.5 22.6 2.7 18.3 18.2 19.6 12.2 30.8 14.5 22.6 18.1 15.3 26.3 17.9 14.7 19.0 34.6 27.2 30.0 21.9 16.7 13.1 17.5 22.8 17.7 17.0 31.2 29.0 38.6 26.5 34.2 34.7 44.9 EIF4G1 "EIF4F, EIF4G, p220, PARK18" ENSG00000114867 "Eukaryotic translation initiation factor 4 gamma 1" Q04637 3 184314495-184335358 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, Protein biosynthesis, Translation regulation" "Initiation factor, RNA-binding, Translational shunt" "Cancer-related genes, Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 348.3" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB014774, HPA028487, HPA043866" Approved Enhanced Cytosol NA NA 330000 "Cluster 27: Non-specific - Gene expression" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "CAB014774: , HPA028487: AB_10602219, HPA043866: AB_2678705" "unprognostic (4.14e-3)" "unprognostic (2.10e-2)" "unprognostic (6.01e-2)" "unprognostic (3.01e-2)" "unprognostic (2.25e-1)" "unprognostic (2.41e-3)" "prognostic unfavorable (7.99e-4)" "unprognostic (4.27e-3)" "unprognostic (2.35e-1)" "unprognostic (1.54e-1)" "unprognostic (1.55e-3)" "unprognostic (7.06e-3)" "unprognostic (2.42e-1)" "unprognostic (7.15e-2)" "unprognostic (2.45e-1)" "unprognostic (1.31e-1)" "unprognostic (2.33e-3)" 86.2 91.8 24.8 75.7 22.2 84.0 69.0 17.9 22.2 66.6 34.1 81.8 62.0 71.3 32.7 126.8 59.6 50.9 90.8 23.3 29.8 53.9 113.0 74.2 55.7 38.5 36.1 57.5 96.2 99.3 57.4 59.4 32.4 62.2 56.5 22.3 93.1 59.2 348.3 116.7 67.2 74.7 24.4 58.2 79.9 64.8 37.4 49.1 71.3 177.0 63.2 76.0 85.3 16.6 559.0 232.3 173.1 205.7 196.9 192.5 322.5 298.6 204.1 315.4 238.8 486.5 173.7 348.4 381.9 367.6 358.5 292.7 322.6 365.8 230.5 375.1 345.8 321.3 226.1 206.4 173.4 321.4 212.2 199.6 206.8 292.4 268.8 152.8 278.3 128.8 239.6 267.2 205.7 403.4 219.7 105.3 368.9 241.3 180.8 221.7 183.4 281.9 156.8 331.8 197.7 174.6 258.1 415.6 187.6 144.6 445.2 206.5 364.1 227.2 228.9 297.3 567.9 203.8 263.2 629.0 260.5 271.4 258.3 8.3 16.0 6.7 11.7 14.4 10.8 7.7 7.8 9.6 12.8 9.2 6.9 7.6 5.6 8.7 21.0 18.1 6.0 12.7 24.8 22.2 17.9 22.2 23.3 29.8 38.5 36.1 32.4 24.4 37.4 16.6 63.9 76.9 72.6 23.8 41.7 59.1 78.2 58.0 70.6 24.2 69.3 46.2 109.4 50.1 72.3 62.5 14.6 64.0 37.6 135.5 13.7 98.8 151.6 53.0 67.1 69.3 55.7 82.7 10.8 135.3 74.8 64.5 75.4 85.6 48.0 163.8 43.5 152.8 66.8 21.9 12.9 97.2 50.8 40.8 39.9 202.7 73.0 48.9 33.8 14.0 53.0 23.2 30.9 4.0 10.1 149.0 69.0 56.1 112.9 96.8 77.0 45.4 51.4 23.2 78.9 81.6 78.9 24.8 41.4 120.7 91.8 79.6 46.0 94.8 108.4 95.6 ELMOD3 "DFNB88, FLJ21977, RBED1, RBM29" ENSG00000115459 "ELMO domain containing 3" Q96FG2 2 85354394-85391752 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "GTPase activation" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA012126 Approved Uncertain Nucleoplasm,Mitochondria NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Mitochondria" "HPA012126: AB_1848130" "unprognostic (1.90e-1)" "unprognostic (9.80e-3)" "unprognostic (1.42e-3)" "unprognostic (1.76e-1)" "unprognostic (3.24e-1)" "unprognostic (1.60e-2)" "unprognostic (1.35e-2)" "unprognostic (1.52e-2)" "unprognostic (4.62e-2)" "unprognostic (5.63e-2)" "prognostic favorable (6.16e-6)" "unprognostic (1.34e-1)" "prognostic unfavorable (1.09e-6)" "unprognostic (5.71e-2)" "unprognostic (1.53e-1)" "unprognostic (9.51e-2)" "prognostic favorable (2.85e-5)" 11.1 8.2 7.0 3.7 7.4 2.7 8.7 6.6 8.0 7.2 5.1 7.6 4.9 5.6 5.9 5.0 6.9 6.1 5.3 5.9 6.4 6.0 8.8 4.9 5.4 6.9 6.8 6.5 6.0 8.9 6.6 6.1 6.2 8.4 4.9 3.1 6.2 7.0 12.1 5.1 5.6 6.7 6.4 6.6 7.1 2.7 6.7 5.4 6.3 10.2 5.0 7.3 6.3 7.0 4.9 6.0 6.7 10.0 20.9 9.2 4.0 8.6 6.7 12.6 11.7 5.0 2.4 3.7 6.7 7.2 15.9 5.1 9.7 11.9 11.4 13.0 6.7 6.5 3.4 3.7 10.9 4.9 8.2 9.6 10.6 12.1 13.6 10.6 9.1 7.4 6.6 4.2 11.9 3.9 7.2 2.9 3.3 9.8 6.4 5.2 13.9 3.5 5.8 3.0 6.3 3.3 5.3 7.3 7.9 7.6 4.0 3.5 4.8 9.1 4.9 7.9 8.0 5.0 9.9 4.9 9.1 5.7 9.4 6.5 2.7 8.0 5.0 1.9 2.7 3.1 3.2 2.0 3.2 2.6 2.7 4.8 2.5 5.0 4.5 0.9 5.5 2.8 7.0 7.4 6.6 8.0 5.9 6.4 6.9 6.8 6.2 6.4 6.7 7.0 9.0 6.4 8.4 36.9 15.7 4.7 10.0 13.0 8.6 27.2 10.7 7.6 5.2 10.0 16.7 11.0 29.2 15.2 9.8 17.3 7.9 8.6 5.6 4.6 6.9 9.5 8.4 7.4 24.3 9.1 5.9 10.0 12.8 4.0 8.9 20.7 12.5 7.5 8.6 30.3 21.4 11.4 14.2 10.0 9.3 5.6 19.3 9.5 17.8 18.7 16.5 14.1 28.8 28.6 49.7 10.4 15.3 23.7 7.7 10.8 24.9 7.1 11.7 30.9 19.7 10.0 8.0 19.7 10.9 6.7 6.5 12.4 14.0 18.3 12.7 9.4 ELOVL4 "CT118, SCA34, STGD2, STGD3" ENSG00000118402 "ELOVL fatty acid elongase 4" Q9GZR5 6 79914814-79947553 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Transferase "Disease variant, FDA approved drug targets, Ichthyosis, Mental retardation, Neurodegeneration, Spinocerebellar ataxia, Stargardt disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 105.5;retina: 176.7" "Cell type enhanced" "Detected in many" "Bipolar cells: 63.8;Cone photoreceptor cells: 148.0;Excitatory neurons: 55.3;Rod photoreceptor cells: 355.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 6 "MAIT T-cell: 23.7" "Lineage enriched" "Detected in single" 238 "T-cells: 23.7" "Cell line enhanced" "Detected in many" "JURKAT: 41.2;MOLT-4: 32.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 46: Photoreceptor cells - Phototransduction" "unprognostic (1.67e-2)" "unprognostic (8.58e-3)" "unprognostic (2.38e-2)" "unprognostic (3.08e-6)" "unprognostic (1.49e-1)" "unprognostic (2.10e-1)" "unprognostic (1.27e-1)" "unprognostic (1.39e-1)" "unprognostic (1.85e-1)" "unprognostic (3.46e-1)" "unprognostic (6.91e-3)" "unprognostic (3.39e-1)" "unprognostic (1.38e-2)" "unprognostic (3.45e-3)" "unprognostic (1.66e-1)" "unprognostic (1.77e-1)" "prognostic unfavorable (6.27e-4)" 0.7 2.0 7.1 1.1 7.0 0.1 4.1 10.0 15.4 3.5 9.7 1.8 0.6 2.2 1.0 10.6 0.7 1.6 0.9 7.8 9.9 1.5 0.1 0.3 0.4 14.4 5.3 1.7 0.5 10.8 6.4 1.7 15.0 4.0 1.0 176.7 2.8 1.7 0.2 43.1 0.8 2.7 4.3 0.5 0.9 5.7 7.4 105.5 1.5 0.5 1.7 1.2 4.0 7.2 0.0 0.8 10.8 12.0 8.8 8.5 1.6 5.6 6.1 4.7 10.2 1.5 0.0 0.0 1.0 7.7 19.3 1.1 14.1 7.9 3.5 0.0 18.2 0.4 2.2 0.0 8.1 4.4 1.7 6.9 2.9 4.8 4.9 6.8 7.8 41.2 0.0 0.0 10.0 1.9 32.8 0.0 10.4 0.0 5.6 0.0 15.5 0.0 0.1 0.0 14.2 4.2 6.0 9.6 1.7 7.4 3.8 0.3 0.8 2.1 4.1 3.2 4.3 7.2 15.3 0.0 5.0 0.0 3.3 0.0 0.0 0.0 2.3 0.0 23.7 0.0 3.3 3.9 0.0 0.0 0.6 1.6 0.0 0.0 0.0 0.0 0.2 0.9 7.1 7.0 10.0 15.4 7.8 9.9 14.4 5.3 15.0 4.3 7.4 7.2 0.7 0.0 0.0 7.5 0.2 11.3 2.3 7.5 15.4 63.8 0.7 1.7 0.9 0.0 3.9 0.0 148.0 0.9 1.7 0.0 0.0 0.1 6.3 0.3 7.0 2.2 8.9 0.0 55.3 0.0 1.5 6.5 0.0 0.1 0.0 1.5 0.0 0.0 0.2 42.1 53.0 0.5 6.1 0.3 1.5 2.1 1.2 0.2 3.6 8.4 0.1 50.7 0.0 20.1 8.6 0.0 1.1 3.4 0.3 3.1 0.0 2.3 0.5 355.3 0.0 2.0 4.3 15.4 15.4 14.8 37.8 1.0 2.6 1.3 0.2 0.7 ELOVL5 "dJ483K16.1, HELO1, SCA38" ENSG00000012660 "ELOVL fatty acid elongase 5" Q9NYP7 6 53267398-53349179 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Transferase "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017042, HPA047752, HPA054197" Enhanced Enhanced "Endoplasmic reticulum" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 35: Glandular cells - Unknown function" "Endoplasmic reticulum" "CAB017042: , HPA047752: AB_2680147, HPA054197: AB_2682413" "unprognostic (7.33e-2)" "unprognostic (5.80e-2)" "unprognostic (1.04e-1)" "unprognostic (1.92e-2)" "unprognostic (1.16e-1)" "unprognostic (5.01e-2)" "unprognostic (3.06e-1)" "unprognostic (2.19e-1)" "unprognostic (4.38e-2)" "unprognostic (1.43e-2)" "unprognostic (3.23e-1)" "unprognostic (6.40e-2)" "prognostic unfavorable (1.94e-6)" "unprognostic (1.58e-1)" "unprognostic (5.12e-2)" "prognostic unfavorable (6.80e-4)" "unprognostic (2.76e-2)" 242.4 134.7 51.3 74.9 67.0 114.6 199.2 74.6 79.2 48.9 49.4 40.0 28.3 39.8 49.7 28.4 46.0 51.3 37.8 50.8 65.3 38.9 108.9 68.4 106.7 80.7 69.0 32.3 15.4 24.3 28.5 40.2 74.5 128.0 18.3 36.5 24.8 103.0 9.9 32.9 47.5 52.4 67.7 56.1 22.8 82.5 65.8 107.3 45.1 19.5 102.4 67.1 27.0 98.9 137.2 98.1 168.0 309.0 436.0 250.8 71.3 155.8 174.2 123.2 171.5 87.4 154.5 154.4 110.3 163.3 193.1 78.9 168.0 142.6 183.7 131.2 117.5 153.1 85.0 122.9 239.0 122.2 107.2 233.6 109.8 123.6 153.9 124.5 139.1 301.4 194.2 87.3 90.3 14.9 364.4 107.9 91.2 5.2 73.6 139.9 115.3 54.3 232.7 80.6 155.7 107.1 129.3 66.9 135.2 108.7 152.3 112.9 133.0 134.7 118.5 242.2 208.8 72.8 72.1 116.2 70.2 173.6 97.8 47.6 49.2 183.7 34.9 34.9 56.5 88.4 58.1 42.7 77.9 101.5 27.8 26.3 261.5 36.7 45.0 20.4 110.0 50.6 51.3 67.0 74.6 79.2 50.8 65.3 80.7 69.0 74.5 67.7 65.8 98.9 48.6 80.1 50.7 75.4 118.3 52.4 108.2 36.8 44.3 11.6 177.3 70.9 23.3 21.5 40.2 12.9 2.1 25.3 55.5 2.1 15.6 34.9 94.2 37.4 53.2 54.4 25.0 77.0 25.8 36.1 58.2 54.8 3.1 66.4 99.0 28.4 39.3 88.7 35.5 8.4 29.8 1.6 16.2 57.3 114.6 181.0 20.8 55.5 48.0 39.4 53.5 83.2 39.1 49.3 111.2 27.8 1.4 32.0 45.2 169.2 21.9 48.4 58.5 6.0 65.7 27.3 77.5 27.0 18.9 35.7 60.9 31.2 97.2 60.0 4.4 73.4 ELP1 "DYS, IKAP, IKBKAP, IKI3, TOT1" ENSG00000070061 "Elongator complex protein 1" O95163 9 108866898-108934328 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation, tRNA processing" "Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 12.8;Alveolar cells type 2: 18.8;Collecting duct cells: 14.7;Exocrine glandular cells: 21.1;Theca cells: 24.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 8 "basophil: 36.6" "Lineage enriched" "Detected in all" 8 "granulocytes: 36.6" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB021340, HPA049677, HPA050686" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 51: Non-specific - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" Cytosol Nucleoplasm "CAB021340: , HPA049677: AB_2680847, HPA050686: AB_2681216" "prognostic unfavorable (1.57e-4)" "unprognostic (8.71e-2)" "unprognostic (5.13e-2)" "unprognostic (4.21e-2)" "unprognostic (6.44e-2)" "unprognostic (4.49e-2)" "unprognostic (2.76e-2)" "unprognostic (1.55e-1)" "unprognostic (1.67e-1)" "unprognostic (4.02e-2)" "unprognostic (1.10e-2)" "unprognostic (2.80e-2)" "unprognostic (1.77e-3)" "unprognostic (1.69e-1)" "unprognostic (1.57e-1)" "unprognostic (2.27e-2)" "unprognostic (4.98e-2)" 13.6 39.7 5.8 6.5 6.2 6.5 13.6 6.9 8.1 21.5 8.4 17.5 5.8 17.1 9.5 13.0 19.9 6.7 18.2 5.9 7.8 14.4 18.4 15.2 9.6 6.6 6.5 29.9 17.6 29.3 38.1 6.8 7.9 18.0 8.1 24.8 14.8 8.3 15.7 15.9 15.9 8.9 5.9 18.2 15.5 12.0 6.9 9.5 20.1 11.4 8.8 15.5 18.3 6.3 15.6 26.7 19.7 12.8 21.7 21.1 21.1 23.4 15.1 20.8 16.9 31.5 9.2 31.0 12.0 20.2 27.5 35.7 40.7 29.8 25.8 28.6 26.6 15.2 38.2 63.3 18.6 28.7 13.7 18.7 19.1 34.5 26.7 18.0 20.9 33.6 43.1 17.9 22.9 25.3 21.2 13.6 32.1 41.0 34.4 20.7 31.9 18.3 17.3 16.1 26.6 23.9 27.8 23.3 15.7 22.4 33.3 14.1 15.4 10.4 16.2 26.0 25.1 15.5 47.2 13.8 20.0 20.2 19.1 36.6 1.4 2.8 2.9 2.2 4.4 2.2 3.4 4.6 2.4 1.2 3.1 4.0 0.2 4.5 3.3 1.6 2.6 2.1 5.8 6.2 6.9 8.1 5.9 7.8 6.6 6.5 7.9 5.9 6.9 6.3 7.3 12.8 18.8 0.0 2.9 0.0 0.0 0.0 0.0 0.0 7.7 7.0 0.0 0.0 3.1 14.7 0.0 6.9 5.8 0.0 0.0 5.8 0.0 9.9 10.6 4.7 0.0 0.0 0.0 21.1 6.2 3.8 0.0 9.6 2.5 11.4 0.0 0.0 6.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 7.6 0.0 0.0 2.7 0.0 0.0 6.3 6.6 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 5.6 2.8 24.4 0.0 0.0 ENTPD1 "ATPDase, CD39, NTPDase-1, SPG64" ENSG00000138185 "Ectonucleoside triphosphate diphosphohydrolase 1" P49961 10 95711779-95877266 "CD markers, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" Hydrolase "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 74.1;Kupffer cells: 110.4;Langerhans cells: 161.3;Microglial cells: 217.4;monocytes: 112.2;Plasma cells: 80.1" "Cancer enhanced" "Detected in all" "thyroid cancer: 17.9" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 102.2" "Group enriched" "Detected in all" 4 "dendritic cells: 31.9;granulocytes: 102.2;monocytes: 41.0" "Group enriched" "Detected in many" 7 "HDLM-2: 147.5;Karpas-707: 135.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002494, HPA014067, CAB079986" Enhanced Uncertain Microtubules NA NA 19000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 2: Karpas-707 - Immune response" "Cluster 41: Macrophages - Immune response" Microtubules "CAB002494: AB_563557, CAB079986: , HPA014067: AB_1848178" "unprognostic (1.14e-1)" "unprognostic (1.01e-2)" "unprognostic (3.11e-1)" "unprognostic (5.67e-2)" "unprognostic (9.68e-3)" "unprognostic (3.45e-3)" "unprognostic (6.31e-2)" "unprognostic (5.26e-3)" "unprognostic (2.73e-1)" "unprognostic (1.28e-2)" "unprognostic (6.40e-2)" "unprognostic (1.41e-1)" "prognostic unfavorable (5.33e-5)" "unprognostic (9.79e-2)" "unprognostic (2.30e-1)" "prognostic favorable (7.89e-4)" "unprognostic (5.09e-2)" 11.8 8.3 5.9 24.7 5.5 27.5 10.8 5.0 6.3 17.5 5.0 14.3 9.3 28.0 19.3 19.2 14.0 27.7 8.5 5.3 6.3 7.6 5.4 16.1 20.2 7.1 6.5 5.5 2.8 3.4 3.9 11.4 7.7 11.2 12.8 6.8 6.0 18.1 4.0 6.3 11.7 49.7 6.2 21.5 7.3 4.5 7.5 6.8 20.0 8.7 25.6 30.6 11.0 6.3 1.4 2.7 5.4 7.1 0.1 0.1 5.0 4.5 1.2 0.0 0.0 4.0 1.6 8.2 3.1 0.0 5.3 2.2 0.0 0.0 0.0 147.5 5.2 7.2 4.0 4.3 0.0 12.5 4.1 0.1 0.0 0.6 0.0 2.4 18.2 2.0 5.3 135.4 0.1 4.4 4.7 5.8 5.9 3.6 2.8 15.3 2.4 4.4 1.7 2.2 5.1 6.2 3.6 3.7 3.9 3.6 5.5 5.9 3.9 3.9 2.8 3.8 5.3 21.6 7.2 0.6 4.3 13.9 2.7 0.7 41.0 102.2 0.6 27.2 1.1 13.7 1.6 1.1 31.9 11.4 0.6 0.6 49.4 1.5 6.7 2.1 13.1 15.5 5.9 5.5 5.0 6.3 5.3 6.3 7.1 6.5 7.7 6.2 7.5 6.3 19.6 0.0 1.1 74.1 40.9 8.9 0.3 0.0 0.6 1.4 0.8 1.5 10.1 0.0 0.7 1.8 2.1 0.6 3.7 0.3 1.9 0.0 10.3 0.6 3.6 60.6 0.0 4.4 2.8 2.0 1.9 15.7 6.1 0.6 3.8 0.3 31.4 0.8 26.6 0.0 5.2 0.1 0.0 110.4 161.3 7.3 0.6 62.1 16.0 217.4 112.2 0.4 0.0 20.6 5.0 0.2 1.2 3.0 80.1 0.5 0.1 0.3 0.8 0.8 6.6 1.0 22.7 10.1 4.4 0.8 11.2 15.7 26.9 15.1 1.0 0.5 EPHA2 ECK ENSG00000142627 "EPH receptor A2" P29317 1 16124337-16156069 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, RAS pathway related proteins" "Angiogenesis, Apoptosis, Cell adhesion, Differentiation, Host-virus interaction" "Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Cataract, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 147.9" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 202.3;Glandular and luminal cells: 182.9;Squamous epithelial cells: 156.3;Suprabasal keratinocytes: 248.3;Urothelial cells: 200.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 94 "plasmacytoid DC: 9.4" "Lineage enriched" "Detected in single" 94 "dendritic cells: 9.4" "Cell line enhanced" "Detected in many" "CAPAN-2: 201.1;PC-3: 229.0;U-251 MG: 242.1;WM-115: 258.2" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" CAB010464 Supported "Nuclear speckles,Golgi apparatus,Plasma membrane,Cell Junctions" NA Yes 12000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 44: Endometrium - Transcription" "Plasma membrane, Cell Junctions" "Nuclear speckles, Golgi apparatus" "CAB010464: AB_631436" "unprognostic (9.41e-2)" "unprognostic (1.67e-1)" "unprognostic (4.13e-2)" "unprognostic (1.67e-2)" "unprognostic (6.22e-2)" "unprognostic (9.12e-2)" "unprognostic (5.24e-2)" "unprognostic (1.29e-3)" "unprognostic (2.52e-2)" "unprognostic (7.05e-3)" "unprognostic (1.52e-3)" "unprognostic (2.77e-1)" "unprognostic (2.65e-2)" "unprognostic (2.08e-1)" "unprognostic (1.73e-1)" "unprognostic (4.77e-3)" "unprognostic (4.40e-2)" 21.4 9.5 3.5 4.8 3.1 0.3 14.6 2.9 3.7 38.2 11.7 12.4 10.0 12.1 1.3 147.9 13.5 28.2 15.8 3.1 3.1 18.7 18.9 17.9 7.6 3.8 3.7 5.8 23.2 3.7 7.4 14.0 3.8 11.2 5.8 6.4 67.7 4.2 4.6 40.3 12.8 3.7 3.6 7.6 15.6 1.8 4.3 3.2 15.2 5.1 11.1 56.1 58.8 3.1 76.9 151.7 41.4 20.1 2.9 3.5 24.3 45.2 63.4 79.9 50.6 63.9 201.1 0.1 189.8 25.9 98.8 30.6 9.9 104.4 27.6 0.4 7.0 0.0 46.7 41.1 51.3 0.1 0.2 4.8 38.1 43.7 95.6 125.0 86.4 0.0 0.3 0.1 51.6 24.3 0.0 0.0 20.0 57.2 229.0 0.1 37.6 0.2 85.1 39.0 0.1 6.4 87.8 21.2 6.1 21.3 3.0 0.9 108.1 28.5 76.7 2.0 242.1 0.0 0.5 0.6 22.0 0.1 258.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.4 0.0 0.0 3.5 3.1 2.9 3.7 3.1 3.1 3.8 3.7 3.8 3.6 4.3 3.1 17.1 54.5 38.4 2.0 1.2 202.3 114.3 110.9 66.0 2.7 39.5 43.9 6.5 44.3 113.4 9.2 4.2 9.7 8.9 96.8 0.0 33.8 5.8 104.5 19.2 26.3 3.0 0.0 0.1 14.2 1.2 5.8 68.3 182.9 5.7 0.4 29.3 23.3 1.9 0.0 0.2 42.0 34.6 1.6 17.0 0.2 3.4 3.7 26.6 4.7 1.1 7.1 0.0 0.0 0.0 104.6 111.7 0.0 0.0 60.8 22.4 1.8 89.8 2.5 32.9 11.6 21.2 0.2 0.8 156.3 248.3 7.5 2.6 0.4 42.9 200.4 EPM2A "LD, LDE" ENSG00000112425 "EPM2A glucan phosphatase, laforin" O95278 6 145382535-145736023 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, Carbohydrate metabolism, Glycogen metabolism" "Hydrolase, Protein phosphatase" "Disease variant, Epilepsy, Glycogen storage disease, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 76.8;tongue: 79.5" "Cell type enhanced" "Detected in many" "Astrocytes: 66.9;Early spermatids: 33.0;Excitatory neurons: 30.4;Inhibitory neurons: 50.7;Oligodendrocyte precursor cells: 56.8;Oligodendrocytes: 60.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "NK-cell: 1.9" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "Daudi: 23.2" "Low region specificity" "Detected in all" "HPA053643, HPA055468" Enhanced Nucleoplasm NA NA "Cluster 15: NK-cells - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA053643: AB_2797247, HPA055468: AB_2797252" "unprognostic (2.37e-2)" "unprognostic (1.03e-1)" "unprognostic (1.99e-1)" "unprognostic (3.34e-3)" "unprognostic (2.92e-3)" "unprognostic (1.22e-1)" "unprognostic (2.15e-2)" "unprognostic (1.63e-1)" "unprognostic (2.37e-2)" "unprognostic (1.50e-1)" "unprognostic (1.52e-4)" "unprognostic (2.28e-1)" "prognostic favorable (4.08e-7)" "unprognostic (4.12e-4)" "unprognostic (2.17e-1)" "unprognostic (2.99e-3)" "unprognostic (1.23e-1)" 5.8 6.0 11.4 1.5 11.7 1.8 3.2 11.9 17.8 3.1 7.3 17.2 3.2 6.0 4.3 9.3 4.4 3.6 24.4 11.6 12.6 8.5 5.7 3.0 3.3 11.9 11.5 5.7 2.4 5.2 3.8 1.5 11.1 6.1 2.9 12.1 3.1 8.8 76.8 2.1 3.8 6.3 10.3 2.1 5.3 3.0 11.5 4.8 3.9 79.5 2.6 9.8 2.7 13.3 1.3 2.1 3.4 6.6 8.6 2.3 1.6 3.1 3.8 2.9 3.5 1.7 1.7 23.2 2.7 3.8 3.5 1.8 1.3 1.6 2.6 9.3 1.9 3.6 2.5 2.7 4.8 12.7 2.4 2.0 7.0 1.7 0.7 3.8 2.0 5.0 1.8 5.4 3.8 3.1 8.4 3.2 3.9 3.2 1.9 4.8 3.1 6.7 2.5 1.8 6.3 6.4 5.5 3.3 7.8 3.1 1.9 7.3 4.6 2.9 1.1 2.7 2.6 4.1 4.6 8.6 2.6 2.8 4.8 0.0 0.0 0.0 0.1 0.5 0.4 0.4 0.4 0.3 0.3 0.4 0.4 0.9 0.1 1.9 0.1 0.3 0.0 0.3 11.4 11.7 11.9 17.8 11.6 12.6 11.9 11.5 11.1 10.3 11.5 13.3 3.9 6.4 1.5 66.9 4.4 0.9 1.0 0.8 0.6 8.4 3.5 2.2 27.8 2.8 2.2 1.8 6.2 1.0 1.9 0.2 11.7 1.0 33.0 1.9 3.6 2.2 1.2 4.4 30.4 2.3 0.7 2.3 1.1 1.4 2.5 6.0 1.4 6.6 2.3 30.3 50.7 1.5 2.0 3.3 1.4 19.8 3.1 3.1 7.2 15.9 1.7 7.9 2.1 56.8 60.1 1.2 1.7 2.2 1.7 1.5 0.5 7.1 2.2 6.3 0.0 6.2 2.4 4.9 1.6 0.8 0.4 0.4 1.8 5.1 1.2 0.3 EPO EP ENSG00000130427 Erythropoietin P01588 7 100720468-100723700 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Predicted secreted proteins" "Erythrocyte maturation" Hormone "Cancer-related genes, Congenital erythrocytosis, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "liver: 47.2" "Cell type enhanced" "Detected in some" "Cytotrophoblasts: 2.9;Exocrine glandular cells: 4.2;Extravillous trophoblasts: 14.0;Hepatocytes: 19.5;Pancreatic endocrine cells: 3.7;Syncytiotrophoblasts: 2.9" "Group enriched" "Detected in many" 5 "liver cancer: 2.7;renal cancer: 5.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "BEWO: 1.6;Hep G2: 6.3" "Not detected" "Not detected" "Not detected" "Not detected" CAB010336 Supported "Secreted to blood" NA NA 12300 "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 15: Hepatocytes - Hemostasis" "CAB010336: AB_2098408" "unprognostic (2.93e-1)" "unprognostic (1.57e-2)" "unprognostic (1.08e-3)" "unprognostic (7.30e-2)" "unprognostic (1.09e-1)" "unprognostic (1.78e-3)" "prognostic unfavorable (5.67e-5)" "unprognostic (3.52e-2)" "unprognostic (5.16e-2)" "unprognostic (9.70e-2)" "unprognostic (2.44e-3)" "unprognostic (3.31e-1)" "prognostic unfavorable (2.18e-6)" "unprognostic (4.80e-2)" "unprognostic (1.87e-1)" "unprognostic (1.59e-2)" "unprognostic (3.34e-1)" 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.2 0.3 2.9 0.1 0.1 0.0 1.8 0.0 0.0 0.1 0.0 0.4 0.1 0.4 3.1 47.2 0.1 0.0 0.2 0.1 0.2 8.3 0.0 0.0 0.0 0.2 0.5 0.0 0.2 1.4 0.5 0.0 0.4 0.0 0.2 0.1 0.1 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.1 0.3 0.1 0.0 0.0 0.0 0.1 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 6.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.3 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.2 0.3 0.1 0.4 0.2 0.1 0.2 0.1 0.1 0.1 0.0 0.0 0.0 0.7 0.2 0.1 0.0 0.0 0.0 0.0 0.2 0.1 0.2 0.0 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.1 4.2 14.0 0.0 0.0 0.0 0.0 0.1 1.4 19.5 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.6 0.0 0.1 2.9 0.0 0.0 0.0 0.0 EPS8 ENSG00000151491 "Epidermal growth factor receptor pathway substrate 8" Q12929 12 15620134-15882329 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" Actin-binding "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 317.0;Sertoli cells: 401.0;Smooth muscle cells: 313.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "non-classical monocyte: 22.2" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC diff: 253.0;HHSteC: 218.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003897 Approved Approved "Golgi apparatus" NA NA 17000 "Cluster 51: Monocytes - Innate immune response" "Cluster 46: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" "Golgi apparatus" "HPA003897: AB_1848224" "unprognostic (6.16e-2)" "unprognostic (1.79e-1)" "unprognostic (1.27e-2)" "unprognostic (5.43e-2)" "unprognostic (2.46e-1)" "unprognostic (1.04e-1)" "unprognostic (5.81e-2)" "unprognostic (1.68e-1)" "unprognostic (2.01e-1)" "unprognostic (1.57e-3)" "prognostic unfavorable (3.33e-7)" "unprognostic (2.68e-1)" "prognostic favorable (1.45e-7)" "unprognostic (7.47e-3)" "unprognostic (7.20e-2)" "prognostic favorable (5.11e-4)" "unprognostic (1.79e-2)" 62.3 13.0 12.9 16.1 17.4 0.6 33.7 15.3 14.0 53.9 14.1 49.7 37.6 46.2 47.1 20.5 20.1 56.0 26.4 11.1 17.2 55.8 37.8 29.0 9.4 18.5 20.1 49.2 15.1 21.6 3.5 53.1 19.7 16.4 53.7 39.8 13.4 39.8 13.8 11.9 42.7 53.7 15.5 11.9 32.0 15.6 16.1 4.8 22.8 24.3 5.2 51.7 21.4 20.8 65.0 38.8 37.7 1.4 253.0 177.6 53.1 73.6 59.8 34.5 46.1 33.3 97.3 0.0 2.4 140.4 114.4 16.4 11.3 9.5 52.4 0.2 12.6 5.7 11.2 34.7 218.1 4.4 0.2 159.8 42.8 91.7 115.7 44.6 17.7 0.2 0.1 0.2 169.0 17.5 0.2 2.8 5.2 50.3 30.8 0.0 109.5 0.8 97.7 92.5 3.1 4.9 21.4 12.4 91.5 6.2 34.2 4.3 28.7 54.7 14.3 32.4 30.7 3.6 0.4 0.1 32.1 10.7 160.0 0.0 2.7 0.2 0.2 10.8 0.1 1.3 0.9 0.4 5.5 0.3 1.1 0.5 4.4 1.0 22.2 0.4 0.1 1.7 12.9 17.4 15.3 14.0 11.1 17.2 18.5 20.1 19.7 15.5 16.1 20.8 121.4 12.8 175.9 91.1 11.6 17.0 39.6 32.0 13.6 9.7 28.7 42.8 27.6 87.2 58.3 23.9 66.7 33.0 15.2 317.0 60.7 69.4 67.6 87.4 72.0 61.4 38.3 0.4 2.2 68.9 7.3 73.4 81.1 152.2 6.3 139.4 36.0 36.0 65.8 6.7 31.1 54.5 67.1 54.1 35.6 49.4 134.8 46.2 35.6 148.0 8.6 15.4 0.0 121.2 96.9 97.0 217.8 43.6 5.2 26.9 69.0 114.6 104.8 153.7 401.0 18.1 313.1 10.9 4.2 22.8 13.1 21.1 11.8 40.0 80.0 97.6 EPS8L2 "FLJ21935, FLJ22171, MGC3088" ENSG00000177106 "EPS8 like 2" Q9H6S3 11 694438-727727 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 188.5" "Cell type enhanced" "Detected in many" "Distal enterocytes: 211.4;Paneth cells: 175.3;Proximal enterocytes: 235.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 8 "plasmacytoid DC: 3.1" "Lineage enriched" "Detected in single" 8 "dendritic cells: 3.1" "Cell line enhanced" "Detected in many" "A-431: 234.3;BEWO: 220.8;CAPAN-2: 206.6;SK-BR-3: 257.5" "Low region specificity" "Detected in many" "Region enriched" "Detected in single" 10 "cerebellum: 9.2" HPA041143 Approved Supported Cytosol NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 37: Intestine - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "HPA041143: AB_10794985" "unprognostic (1.39e-2)" "unprognostic (1.07e-1)" "unprognostic (7.58e-2)" "unprognostic (3.40e-2)" "prognostic unfavorable (2.31e-4)" "unprognostic (6.87e-2)" "unprognostic (3.27e-2)" "unprognostic (1.33e-1)" "unprognostic (4.82e-2)" "unprognostic (4.26e-2)" "unprognostic (2.54e-1)" "unprognostic (1.92e-1)" "unprognostic (3.25e-2)" "unprognostic (2.51e-2)" "unprognostic (4.19e-1)" "unprognostic (2.79e-1)" "unprognostic (5.03e-2)" 7.8 11.2 5.2 5.7 4.8 0.0 27.0 8.9 5.5 49.4 4.9 42.7 100.8 11.4 3.5 188.5 19.2 13.3 4.3 4.5 6.8 98.4 101.7 32.4 0.7 10.9 9.2 11.8 43.7 3.8 11.5 17.7 6.2 29.3 15.5 1.0 94.6 15.2 1.3 76.3 105.0 2.9 7.1 1.4 48.1 3.2 7.1 2.0 70.2 0.4 10.9 17.5 80.1 6.5 234.3 68.6 0.2 1.6 2.7 14.4 220.8 20.1 20.3 29.2 12.5 51.4 206.6 0.4 81.6 21.4 5.4 122.4 0.6 117.8 6.4 0.6 5.4 0.0 27.7 94.7 16.3 0.3 0.4 8.1 77.8 8.0 18.7 12.3 0.2 0.1 1.8 1.1 3.2 72.1 0.5 1.3 2.7 71.5 24.0 0.5 0.8 1.8 103.8 55.2 0.8 0.8 75.9 257.5 0.5 14.3 94.9 0.2 1.5 11.2 27.3 7.2 1.6 0.9 1.0 0.8 6.1 0.6 0.9 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 3.1 0.0 0.1 5.2 4.8 8.9 5.5 4.5 6.8 10.9 9.2 6.2 7.1 7.1 6.5 1.8 141.1 51.8 3.9 11.2 19.8 26.2 48.8 51.8 0.6 39.1 37.0 4.5 57.2 62.4 90.1 0.0 47.9 21.6 211.4 27.4 55.2 1.0 47.3 7.1 4.7 43.8 1.3 3.1 80.0 33.4 11.5 131.0 60.8 7.0 0.4 0.7 59.4 4.7 0.0 3.8 76.8 32.6 2.1 7.8 2.3 18.0 2.7 14.2 2.8 3.1 10.0 16.5 2.0 0.7 83.2 175.3 11.7 7.6 33.6 235.9 108.2 60.9 1.5 0.0 0.9 7.5 1.1 4.8 74.9 24.4 92.5 18.6 0.9 77.2 32.1 ERBB4 "ALS19, HER4" ENSG00000178568 "Erb-b2 receptor tyrosine kinase 4" Q15303 2 211375717-212538841 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Apoptosis, Lactation, Transcription, Transcription regulation" "Activator, Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Amyotrophic lateral sclerosis, Cancer-related genes, Disease variant, FDA approved drug targets, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 16.9;fallopian tube: 11.2" "Cell type enhanced" "Detected in many" "Astrocytes: 2020.2;Inhibitory neurons: 6091.7;Oligodendrocyte precursor cells: 2369.0;Oligodendrocytes: 1049.9" "Group enriched" "Detected in many" 4 "breast cancer: 4.1;endometrial cancer: 2.1;glioma: 1.2;ovarian cancer: 2.8;testis cancer: 1.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 6.9;EFO-21: 5.1;HEK 293: 3.8;RPTEC TERT1: 5.6;SCLC-21H: 3.1;T-47d: 5.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000276, HPA012016, CAB025522" Enhanced NA NA 220000 "Cluster 57: Non-specific - Angiogenesis" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB000276: , CAB025522: , HPA012016: AB_1846541" "unprognostic (1.48e-1)" "unprognostic (3.28e-1)" "unprognostic (4.31e-3)" "unprognostic (1.76e-3)" "unprognostic (3.59e-1)" "unprognostic (2.75e-1)" "unprognostic (2.88e-1)" "unprognostic (9.56e-2)" "unprognostic (2.07e-1)" "unprognostic (4.67e-3)" "unprognostic (1.07e-1)" "unprognostic (3.61e-1)" "unprognostic (7.14e-3)" "unprognostic (1.49e-3)" "unprognostic (1.41e-1)" "unprognostic (1.14e-1)" "unprognostic (4.11e-2)" 0.3 0.4 10.0 0.0 13.3 0.0 5.6 10.5 11.5 2.9 0.0 0.1 0.0 0.2 0.0 0.1 11.2 0.0 3.0 9.9 12.7 5.1 0.0 0.8 0.0 4.9 16.9 0.1 0.6 3.1 2.4 0.1 7.6 0.3 0.0 2.0 4.7 1.2 1.5 0.3 0.0 0.0 4.3 0.0 0.4 3.3 8.0 0.0 1.6 1.7 0.0 0.1 0.1 6.1 0.0 0.0 6.9 0.2 0.0 0.0 0.0 0.0 0.2 0.3 0.1 0.0 0.0 0.0 5.1 0.7 0.0 0.3 0.2 0.0 0.0 0.1 3.8 0.0 1.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 2.1 0.0 0.0 0.3 0.0 5.6 0.3 3.1 0.2 0.0 0.1 0.1 0.1 5.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.0 13.3 10.5 11.5 9.9 12.7 4.9 16.9 7.6 4.3 8.0 6.1 0.4 0.0 12.6 2020.2 0.0 0.6 0.9 1.1 0.6 15.9 45.6 17.0 27.2 0.0 10.2 12.9 0.0 0.0 0.2 0.0 5.9 0.5 6.7 25.4 1.0 1.0 0.0 0.0 62.0 0.5 0.2 1.8 0.0 25.8 0.0 5.4 0.0 0.0 0.1 0.0 6091.7 0.0 2.0 0.0 0.3 2.2 1.8 0.3 3.6 96.5 0.0 9.1 0.0 2369.0 1049.9 0.0 0.0 0.4 0.0 1.6 0.0 0.2 28.1 1.9 6.6 4.1 3.0 1.8 2.6 0.2 1.3 0.0 0.2 0.0 0.0 1.2 ERCC6 "ARMD5, CKN2, CSB, RAD26" ENSG00000225830 "ERCC excision repair 6, chromatin remodeling factor" "P0DP91, Q03468" 10 49454168-49539538 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Neurogenesis, Transcription, Transcription regulation" "DNA-binding, Helicase, Hydrolase" "Age-related macular degeneration, Cancer-related genes, Cataract, Cockayne syndrome, Deafness, Disease variant, Dwarfism, Mental retardation, Premature ovarian failure, Xeroderma pigmentosum" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "hTERT-HME1: 53.8;hTERT-RPE1: 123.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA071297 Approved "Nucleoplasm,Nuclear bodies" Yes No "Cluster 6: Non-specific - Transcription" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "Nuclear bodies" "HPA071297: AB_2732177" "unprognostic (1.92e-2)" "unprognostic (1.85e-1)" "unprognostic (9.79e-3)" "unprognostic (7.26e-2)" "unprognostic (5.45e-2)" "unprognostic (2.95e-2)" "unprognostic (3.03e-2)" "unprognostic (2.99e-2)" "unprognostic (1.71e-2)" "unprognostic (1.13e-1)" "unprognostic (1.80e-1)" "unprognostic (4.57e-2)" "unprognostic (1.04e-1)" "unprognostic (8.61e-2)" "unprognostic (4.75e-2)" "unprognostic (1.73e-1)" "unprognostic (7.05e-2)" 2.7 2.1 1.6 1.9 1.5 4.6 3.8 3.0 2.3 3.1 7.7 2.4 2.0 3.0 1.5 3.8 2.9 2.7 3.4 1.2 1.1 3.2 3.3 2.7 2.9 2.4 1.9 4.5 3.1 5.9 2.8 3.4 2.1 3.3 2.7 3.1 3.2 2.2 3.5 4.6 2.5 2.3 2.2 2.9 2.4 3.1 2.1 3.3 5.1 3.6 3.4 2.6 3.3 1.9 11.2 5.5 4.1 2.1 6.6 10.5 3.4 21.2 27.1 14.1 9.9 6.2 5.6 4.9 3.7 18.7 6.7 9.5 6.3 16.6 13.5 8.4 4.1 3.9 21.7 3.4 3.9 5.0 3.7 4.3 17.2 12.9 53.8 123.4 19.8 2.9 6.8 0.8 16.8 8.3 3.4 2.0 4.0 3.5 10.2 2.3 5.8 2.6 4.1 7.1 5.9 4.7 15.4 3.6 8.2 9.4 7.1 2.7 38.9 7.0 5.5 8.6 5.2 3.3 4.5 4.1 7.3 5.0 5.1 13.1 3.0 7.5 4.1 2.6 3.0 6.8 2.3 2.2 3.9 5.2 2.8 1.4 7.2 1.2 5.3 2.2 3.1 1.8 1.6 1.5 3.0 2.3 1.2 1.1 2.4 1.9 2.1 2.2 2.1 1.9 6.9 16.0 13.2 14.7 6.0 3.6 1.4 1.5 5.2 0.0 7.1 7.1 7.1 5.7 8.2 9.2 0.0 2.5 10.9 4.8 5.9 5.2 11.3 8.1 8.7 5.1 1.2 1.3 24.3 6.0 2.1 4.9 2.0 10.1 7.6 8.9 5.3 4.3 2.6 0.0 21.7 5.3 0.0 4.4 2.6 15.3 2.8 8.0 1.8 23.4 11.2 0.0 4.1 17.6 16.6 5.2 2.6 2.2 3.6 2.5 5.0 3.6 9.0 0.0 6.6 4.4 4.2 5.3 5.0 3.5 4.1 1.8 7.4 11.4 2.8 1.9 ERCC8 "CKN1, CSA" ENSG00000049167 "ERCC excision repair 8, CSA ubiquitin ligase complex subunit" Q13216 5 60866454-60945073 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Cockayne syndrome, Deafness, Disease variant, Dwarfism" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 47.3;Excitatory neurons: 51.8;Inhibitory neurons: 47.9;Oligodendrocyte precursor cells: 44.2;Oligodendrocytes: 57.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029328 Approved "Nuclear speckles" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 29: Early spermatids - Spermatogenesis" "Nuclear speckles" "HPA029328: AB_2673000" "unprognostic (5.45e-2)" "unprognostic (1.90e-1)" "unprognostic (2.56e-2)" "unprognostic (6.59e-2)" "unprognostic (1.68e-2)" "unprognostic (4.96e-2)" "unprognostic (2.10e-3)" "unprognostic (9.68e-2)" "unprognostic (3.85e-2)" "unprognostic (3.23e-1)" "unprognostic (7.49e-2)" "unprognostic (1.09e-1)" "unprognostic (4.75e-3)" "unprognostic (1.78e-2)" "unprognostic (1.97e-1)" "unprognostic (6.31e-3)" "unprognostic (7.19e-2)" 3.4 3.1 2.3 1.6 2.4 2.0 3.1 3.1 3.2 2.5 1.5 2.6 1.7 3.0 1.4 2.8 2.4 1.9 3.2 2.3 1.7 4.0 3.2 2.2 1.6 1.9 1.8 2.7 2.7 3.0 2.5 2.1 2.1 2.2 2.4 2.7 2.7 2.1 3.0 2.4 2.2 2.3 1.4 2.6 2.5 4.1 2.0 2.8 2.9 2.9 2.2 2.5 2.6 2.9 4.8 4.9 7.3 9.5 6.0 4.2 8.2 7.6 6.4 8.9 9.2 6.9 8.6 7.3 9.4 4.2 14.4 4.0 10.6 7.4 11.1 7.6 6.0 5.3 7.3 7.7 5.0 4.9 4.5 6.5 6.5 6.1 7.5 3.3 9.9 8.8 8.0 4.2 5.2 8.1 6.9 8.0 6.5 2.8 3.1 11.0 9.6 9.1 4.7 5.9 6.1 11.3 8.6 3.6 6.5 7.6 11.2 3.6 3.8 3.8 7.4 7.6 10.1 5.5 11.9 12.7 5.9 10.1 8.3 0.5 4.2 0.9 3.1 3.4 2.5 2.7 2.4 2.8 7.1 1.8 2.8 3.2 0.7 2.2 1.4 3.5 3.3 2.1 2.3 2.4 3.1 3.2 2.3 1.7 1.9 1.8 2.1 1.4 2.0 2.9 3.4 3.2 4.6 28.4 6.6 2.9 3.1 6.9 9.6 0.0 4.9 5.5 4.1 7.2 3.3 16.5 0.0 7.7 4.2 1.6 15.6 5.0 47.3 4.3 7.2 3.9 0.0 10.5 51.8 5.2 9.2 5.2 5.1 3.1 5.7 8.1 3.9 5.0 6.4 0.0 47.9 3.8 4.1 7.1 5.5 11.2 4.7 6.5 7.2 20.6 7.9 0.0 6.2 44.2 57.4 5.2 2.2 3.0 11.1 3.8 2.0 7.1 6.3 0.0 0.0 4.0 4.6 22.5 9.2 10.4 4.3 3.4 6.5 8.9 4.4 3.5 ERLIN1 "C10orf69, Erlin-1, KE04, SPFH1, SPG62" ENSG00000107566 "ER lipid raft associated 1" O75477 10 100150094-100186033 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters" "Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 114.1" "Cell type enhanced" "Detected in many" "Hepatocytes: 77.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011252 Enhanced Supported "Endoplasmic reticulum" "Intracellular and membrane" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 85: Liver - Metabolism" "Cluster 32: U-937 - Innate immune response" "Cluster 66: Spermatocytes - Spermatogenesis" "Endoplasmic reticulum" "HPA011252: AB_1853965" "unprognostic (3.22e-1)" "unprognostic (1.31e-1)" "unprognostic (1.57e-1)" "unprognostic (6.98e-3)" "unprognostic (2.69e-1)" "unprognostic (1.70e-2)" "unprognostic (2.30e-1)" "prognostic unfavorable (7.63e-4)" "unprognostic (1.26e-1)" "unprognostic (9.68e-2)" "unprognostic (1.99e-3)" "unprognostic (9.09e-2)" "unprognostic (1.32e-3)" "unprognostic (6.10e-3)" "unprognostic (1.76e-1)" "unprognostic (2.97e-1)" "unprognostic (1.93e-1)" 29.4 14.2 8.6 21.4 10.5 76.2 21.4 9.5 10.1 27.5 10.3 37.0 40.4 21.8 17.6 32.8 31.6 16.3 11.0 9.6 9.4 27.2 114.1 19.1 14.5 8.6 8.2 30.4 19.2 19.4 5.4 42.2 9.0 17.7 38.2 10.8 15.1 16.4 8.6 22.5 30.2 22.4 8.8 16.6 36.8 28.0 9.0 15.6 26.2 13.6 21.2 28.6 19.1 9.7 97.4 95.3 46.9 86.3 113.5 107.9 96.8 148.7 138.3 120.2 137.5 64.0 109.9 42.6 59.7 139.9 100.5 98.5 42.6 90.0 164.1 26.1 38.8 36.7 38.5 83.5 47.6 128.4 39.4 62.6 53.6 105.8 129.2 114.9 90.1 43.5 36.8 25.2 130.2 40.7 33.5 65.9 33.8 66.2 40.4 28.3 77.2 31.6 53.9 37.6 19.1 31.1 85.6 23.6 56.0 53.8 59.3 109.0 101.7 118.7 92.4 72.4 160.8 19.6 35.2 57.1 105.6 204.8 60.6 8.1 20.4 24.4 10.5 15.1 9.3 7.4 7.9 8.6 16.3 6.7 8.1 10.9 15.0 9.9 11.9 4.1 5.6 9.7 8.6 10.5 9.5 10.1 9.6 9.4 8.6 8.2 9.0 8.8 9.0 9.7 28.2 0.0 11.5 5.2 6.4 15.8 11.3 16.1 12.5 4.6 13.4 12.3 4.8 5.7 14.6 14.7 6.2 20.6 6.4 31.5 0.0 9.9 28.9 16.3 19.5 18.8 13.2 19.1 16.2 10.9 62.7 17.1 20.4 20.9 8.2 19.7 13.6 77.6 14.3 3.3 14.8 27.5 0.0 14.4 7.2 12.9 15.2 12.9 10.6 12.2 13.3 5.9 6.2 15.6 21.0 9.5 19.8 7.9 4.7 12.7 25.6 12.6 30.2 6.2 0.0 14.3 11.8 50.9 15.4 20.6 20.3 24.8 6.6 19.6 27.6 15.6 ERLIN2 "C8orf2, Erlin-2, NET32, SPFH2, SPG18" ENSG00000147475 "ER lipid raft associated 2" O94905 8 37736601-37758422 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters" "Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002025, CAB014894" Supported Supported "Endoplasmic reticulum" "Intracellular and membrane" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 1: Thyroid gland - Transcription" "Cluster 38: EFO-21 - Unknown function" "Cluster 44: Endometrium - Transcription" "Endoplasmic reticulum" "CAB014894: , HPA002025: AB_1080077" "unprognostic (5.82e-3)" "unprognostic (2.45e-1)" "prognostic favorable (5.16e-4)" "unprognostic (1.08e-2)" "prognostic unfavorable (4.51e-4)" "unprognostic (3.39e-2)" "unprognostic (1.89e-1)" "unprognostic (3.77e-2)" "unprognostic (6.67e-2)" "unprognostic (4.21e-2)" "unprognostic (1.88e-2)" "unprognostic (1.78e-3)" "prognostic favorable (6.67e-6)" "unprognostic (4.78e-2)" "unprognostic (2.83e-1)" "unprognostic (3.43e-1)" "unprognostic (2.33e-1)" 20.3 17.8 15.7 14.6 17.3 14.4 25.0 16.5 16.8 20.0 27.2 24.2 17.7 21.2 32.3 17.9 30.1 19.8 17.8 14.2 16.3 40.4 40.8 15.5 11.5 18.0 18.5 30.8 26.2 41.4 8.3 21.2 17.7 25.4 25.0 21.6 29.4 23.8 18.9 15.3 23.6 19.5 17.9 14.6 24.9 17.0 15.6 14.7 46.5 14.1 12.6 16.8 10.3 18.6 39.0 38.5 43.0 31.4 47.3 33.9 47.2 59.1 51.9 31.8 33.2 20.1 50.8 18.9 95.8 63.4 30.3 41.4 31.2 48.4 46.8 11.2 24.2 27.8 22.7 22.7 31.5 17.8 34.1 43.3 49.1 46.3 48.1 39.6 30.7 17.2 51.1 17.7 47.4 18.3 25.8 14.7 45.9 53.8 17.7 17.9 29.9 15.2 42.8 41.9 7.7 20.7 39.3 12.6 35.6 50.1 62.0 27.1 31.1 30.9 26.4 56.8 31.1 24.3 41.0 24.2 55.0 28.4 40.7 1.3 6.5 13.4 4.4 7.0 3.6 4.5 2.7 3.5 5.4 2.3 4.1 3.8 6.1 2.5 9.6 7.6 5.5 3.1 15.7 17.3 16.5 16.8 14.2 16.3 18.0 18.5 17.7 17.9 15.6 18.6 14.7 12.8 14.3 21.5 7.1 9.7 10.0 18.5 13.1 25.2 24.9 20.7 30.2 25.8 22.8 33.1 20.9 17.9 6.0 19.0 9.8 23.8 21.3 31.3 18.5 13.6 11.4 8.0 3.7 22.1 27.0 18.8 17.3 27.8 3.8 14.4 17.5 41.0 20.6 16.8 6.4 24.3 20.3 23.9 6.6 16.8 11.8 16.1 14.2 7.5 12.3 23.5 5.2 11.6 16.7 18.8 17.4 17.7 16.8 15.2 25.4 19.8 47.6 18.7 19.7 19.1 14.8 47.4 18.5 21.9 7.4 15.7 7.1 12.9 25.4 12.8 ESPN DFNB36 ENSG00000187017 Espin B1AK53 1 6424776-6461367 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Hearing Actin-binding "Deafness, Disease variant, Non-syndromic deafness, Retinitis pigmentosa, Usher syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 129.1;retina: 117.8;testis: 145.3" "Cell type enhanced" "Detected in many" "Distal enterocytes: 175.5;Early spermatids: 137.5;Late spermatids: 461.6;Muller glia cells: 272.5;Paneth cells: 186.3;Proximal enterocytes: 512.1" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in many" 6 "cerebellum: 13.4;thalamus: 6.1" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 48.9;Hep G2: 81.5;SK-BR-3: 160.1;T-47d: 53.6" "Low region specificity" "Detected in some" "Region enhanced" "Detected in some" "cerebellum: 2.6" "HPA028674, HPA060220" Enhanced Approved Vesicles NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 45: Enterocytes - Digestion" Vesicles "HPA028674: AB_10601316, HPA060220: AB_2684224" "unprognostic (5.06e-2)" "unprognostic (1.18e-2)" "unprognostic (2.69e-1)" "unprognostic (1.28e-1)" "unprognostic (2.19e-2)" "unprognostic (1.41e-1)" "unprognostic (1.59e-1)" "unprognostic (2.28e-1)" "unprognostic (1.16e-1)" "unprognostic (5.71e-2)" "unprognostic (7.48e-3)" "unprognostic (5.53e-2)" "unprognostic (6.26e-3)" "unprognostic (5.51e-2)" "unprognostic (1.16e-1)" "unprognostic (3.04e-2)" "unprognostic (1.17e-2)" 0.6 5.7 0.4 2.6 1.0 28.0 9.2 13.4 1.0 30.3 0.2 28.2 90.4 2.4 39.9 34.3 18.6 0.3 0.9 0.4 1.7 63.4 129.1 3.2 0.3 0.6 1.3 0.4 0.9 26.8 42.1 0.9 1.1 10.0 6.8 117.8 9.4 6.2 0.8 91.7 89.5 0.8 0.3 0.9 2.7 145.3 6.1 1.6 0.4 0.0 1.7 1.3 22.3 0.5 14.1 0.7 0.6 0.1 0.0 0.0 48.9 0.0 0.0 0.2 0.0 29.9 1.5 0.5 6.5 0.0 0.1 32.6 2.3 0.1 0.0 2.0 0.7 0.4 0.7 81.5 0.0 0.6 2.7 0.1 0.6 0.0 0.0 0.0 0.0 1.0 17.6 0.0 0.0 28.2 0.2 1.0 0.6 3.8 12.2 0.0 0.4 10.9 0.2 0.1 21.0 0.7 3.7 160.1 5.0 0.3 53.6 7.4 15.6 0.1 0.8 0.6 0.0 0.0 0.2 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.8 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.4 1.0 13.4 1.0 0.4 1.7 0.6 1.3 1.1 0.3 6.1 0.5 0.2 0.0 0.6 0.0 0.8 7.8 2.4 4.5 12.5 5.6 10.7 3.9 1.4 11.5 3.8 9.2 68.8 3.0 0.2 175.5 13.7 0.2 137.5 19.1 0.9 0.8 6.0 8.2 0.2 3.1 0.5 0.3 5.6 12.4 0.0 0.0 3.9 109.4 0.2 0.0 0.2 36.3 8.2 3.2 0.9 461.6 3.7 1.5 0.0 0.0 0.0 272.5 0.0 0.0 0.1 0.1 186.3 2.2 0.0 1.6 512.1 102.2 9.0 72.5 0.0 0.0 0.2 12.3 3.9 17.6 22.7 6.6 1.5 0.0 35.3 2.9 ESRP1 "FLJ20171, RBM35A" ENSG00000104413 "Epithelial splicing regulatory protein 1" Q6NXG1 8 94641074-94707466 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "mRNA processing, mRNA splicing" RNA-binding "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Intestinal goblet cells: 107.2;Suprabasal keratinocytes: 79.1" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 138.3;BEWO: 101.1;CAPAN-2: 140.8;hTCEpi: 226.5;OE19: 142.6;RT4: 99.1;T-47d: 108.0" "Not detected" "Not detected" "Not detected" "Not detected" "HPA023719, HPA023720, HPA067104" Enhanced Enhanced "Nucleoplasm,Nuclear bodies" "Intracellular and membrane" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 27: Mucus-secreting cells - Mucin production" "Nuclear bodies" Nucleoplasm "HPA023719: AB_1856124, HPA023720: AB_1856125, HPA067104: AB_2685779" "prognostic unfavorable (9.28e-4)" "unprognostic (7.12e-2)" "unprognostic (2.75e-2)" "prognostic unfavorable (3.56e-4)" "unprognostic (4.12e-1)" "unprognostic (6.99e-3)" "unprognostic (2.70e-1)" "unprognostic (2.61e-2)" "unprognostic (5.19e-2)" "unprognostic (5.51e-2)" "prognostic unfavorable (2.05e-4)" "unprognostic (4.48e-2)" "prognostic favorable (1.96e-8)" "unprognostic (1.34e-1)" "unprognostic (2.63e-1)" "unprognostic (4.96e-2)" "unprognostic (1.29e-1)" 0.2 0.0 0.0 5.2 0.0 0.0 24.2 0.0 0.0 15.5 0.0 57.1 25.2 3.4 29.6 64.2 21.3 8.5 0.1 0.0 0.0 8.5 0.4 15.8 0.0 0.0 0.1 0.1 42.6 28.4 7.2 12.2 0.0 19.9 62.8 0.0 25.9 10.0 0.1 60.6 22.0 2.5 0.0 0.0 38.6 0.6 0.4 5.2 36.6 0.0 15.3 22.5 28.8 0.0 138.3 0.0 0.0 0.2 0.0 0.0 101.1 0.0 0.0 0.0 0.0 44.6 140.8 0.0 3.8 0.0 0.1 81.6 3.8 70.9 0.0 0.1 0.0 0.3 0.1 0.0 0.0 0.0 0.1 0.0 226.5 0.0 1.4 0.0 0.0 10.7 0.0 0.0 0.0 67.3 1.9 0.4 12.4 142.6 3.4 0.0 0.0 18.3 17.4 99.1 35.1 0.3 0.0 21.0 14.0 21.4 108.0 0.9 0.0 0.1 0.2 0.1 0.3 12.0 13.8 0.3 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.2 38.5 36.7 0.0 0.6 44.6 18.9 30.4 35.9 0.0 29.4 18.0 1.0 21.5 32.4 27.6 0.0 55.1 0.5 76.2 13.7 19.6 12.9 47.1 3.7 0.9 33.1 0.0 2.6 27.5 69.1 0.9 58.1 46.5 1.3 0.0 0.4 0.1 6.0 0.0 0.4 107.2 16.2 0.0 3.2 10.3 0.0 0.5 24.9 0.0 0.6 0.0 0.0 0.5 0.4 21.7 48.1 0.7 1.8 25.1 25.5 0.3 35.0 0.0 0.0 0.0 1.2 0.6 0.9 71.3 79.1 62.1 0.8 0.0 73.9 40.1 ESRRB "DFNB35, ERR2, ERRb, ERRbeta, ESRL2, NR3B2" ENSG00000119715 "Estrogen related receptor beta" O95718 14 76310712-76501837 "Disease related genes, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "DNA-binding, Receptor" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "retina: 36.5" "Cell type enhanced" "Detected in some" "Distal tubular cells: 13.7;Early spermatids: 14.1;Horizontal cells: 55.5;Late spermatids: 37.6;Rod photoreceptor cells: 40.3" "Cancer enhanced" "Detected in single" "testis cancer: 0.6" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HMC-1: 1.3;K-562: 5.0;U-266/70: 2.3" "Low region specificity" "Detected in many" "Not detected" "Not detected" HPA074772 Supported Nucleoplasm,Cytosol NA NA "Cluster 77: Retina - Visual perception" "Cluster 1: K-562 - Erythropoiesis" "Cluster 46: Photoreceptor cells - Phototransduction" Nucleoplasm Cytosol "HPA074772: " "unprognostic (1.12e-1)" "unprognostic (1.34e-2)" "unprognostic (6.28e-2)" "unprognostic (3.92e-5)" "unprognostic (5.18e-2)" "unprognostic (3.15e-2)" "unprognostic (2.14e-1)" "unprognostic (1.48e-1)" "unprognostic (2.28e-2)" "unprognostic (2.24e-2)" "unprognostic (2.16e-2)" "unprognostic (4.11e-2)" "unprognostic (2.68e-1)" "unprognostic (3.46e-1)" "unprognostic (1.89e-1)" "unprognostic (2.12e-4)" "unprognostic (4.40e-2)" 0.0 0.0 0.4 0.0 0.4 0.0 0.3 0.4 0.4 0.0 1.2 0.0 0.0 0.0 0.2 0.0 0.1 0.0 4.9 0.3 0.6 6.6 0.0 0.0 0.0 1.5 1.2 0.0 0.0 0.0 0.0 0.0 0.7 0.1 0.0 36.5 0.0 0.0 6.5 0.0 0.0 0.0 0.6 0.1 2.4 1.2 0.9 0.1 0.0 1.6 0.0 0.0 0.0 0.8 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.7 0.2 0.0 0.0 0.0 0.3 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 5.0 0.2 0.0 0.6 0.0 0.2 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.4 0.0 0.0 0.5 0.0 0.4 0.0 0.2 2.3 0.7 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.4 0.4 0.4 0.3 0.6 1.5 1.2 0.7 0.6 0.9 0.8 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 2.4 1.0 0.4 5.8 0.0 0.0 0.0 2.1 0.0 0.0 0.0 13.7 0.0 14.1 0.0 0.0 0.8 0.0 0.0 1.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 55.5 2.0 0.0 0.0 0.0 0.0 37.6 0.0 0.1 0.0 3.7 0.0 4.6 0.0 1.5 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 40.3 0.0 0.1 0.8 0.5 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 EYA4 "CMD1J, DFNA10" ENSG00000112319 "EYA transcriptional coactivator and phosphatase 4" O95677 6 133240598-133532128 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Transcription, Transcription regulation" "Activator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase" "Cardiomyopathy, Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 27.6;tongue: 21.3" "Cell type enhanced" "Detected in many" "Collecting duct cells: 46.0;Inhibitory neurons: 139.0;Oligodendrocytes: 79.2;Skeletal myocytes: 26.2" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 25.4;GAMG: 25.6;HeLa: 74.3;RH-30: 23.8;U-87 MG: 24.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA004805, HPA038771, HPA038772" Enhanced Approved Nucleoplasm No NA "Cluster 80: Striated muscle - Unknown function" "Cluster 20: HeLa - Mitochondria" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA004805: AB_10669750, HPA038771: AB_10671865, HPA038772: AB_10673119" "unprognostic (1.60e-1)" "unprognostic (3.34e-1)" "unprognostic (1.27e-1)" "unprognostic (2.04e-9)" "unprognostic (1.64e-1)" "unprognostic (3.08e-2)" "unprognostic (3.44e-2)" "unprognostic (7.21e-2)" "unprognostic (9.07e-2)" "unprognostic (2.04e-2)" "unprognostic (2.80e-1)" "unprognostic (2.29e-1)" "unprognostic (8.27e-4)" "unprognostic (1.82e-3)" "unprognostic (6.67e-2)" "unprognostic (9.55e-2)" "unprognostic (2.51e-2)" 1.1 2.5 2.6 0.1 1.9 0.0 0.4 2.2 1.9 2.6 13.3 0.2 0.2 0.5 1.2 0.4 7.4 0.5 5.8 2.3 1.2 5.0 0.0 1.8 0.1 5.6 7.9 1.2 0.2 0.0 0.8 0.0 4.5 5.7 0.2 0.1 0.2 11.8 27.6 0.0 0.1 0.3 4.5 0.4 0.4 3.0 3.3 6.6 2.1 21.3 0.5 2.2 2.3 4.9 0.0 25.4 2.4 0.0 0.0 0.0 0.0 0.0 20.4 0.5 2.9 0.1 0.1 0.1 19.6 0.0 25.6 0.0 15.4 6.7 0.0 0.0 20.2 2.8 74.3 0.0 0.6 0.0 6.8 5.1 0.0 14.4 4.5 3.4 0.0 0.0 0.0 10.7 8.1 0.0 0.0 0.0 0.0 0.3 1.6 0.3 23.8 0.0 0.0 3.9 3.7 4.1 0.2 0.0 11.4 0.1 0.0 0.0 0.0 0.0 0.0 0.1 18.4 7.2 3.4 0.0 24.6 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 1.9 2.2 1.9 2.3 1.2 5.6 7.9 4.5 4.5 3.3 4.9 0.3 12.8 1.8 2.6 0.0 0.1 0.1 13.3 0.0 0.0 0.0 0.0 14.4 0.0 6.7 46.0 0.0 0.0 0.0 0.1 0.0 0.1 4.4 0.1 0.1 0.5 1.8 0.0 4.8 0.2 0.0 2.9 0.0 0.1 0.0 1.5 0.4 0.1 0.0 0.0 139.0 0.0 8.2 1.0 0.0 2.6 0.6 0.2 0.0 2.8 7.2 0.0 0.0 1.5 79.2 0.0 0.0 0.0 0.0 0.2 0.0 0.2 4.8 0.0 0.0 26.2 3.3 7.9 7.1 0.0 0.0 0.0 0.1 1.5 0.0 0.2 EYS "bA166P24.2, bA307F22.3, bA74E24.1, C6orf178, C6orf179, C6orf180, dJ1018A4.2, dJ303F19.1, EGFL10, EGFL11, RP25, SPAM" ENSG00000188107 "Eyes shut homolog" Q5T1H1 6 63719980-65707226 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" "Sensory transduction, Vision" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 36 "retina: 24.8" "Cell type enhanced" "Detected in some" "Cone photoreceptor cells: 316.9;Early spermatids: 87.3;Inhibitory neurons: 83.8;Late spermatids: 45.7;Rod photoreceptor cells: 140.2" "Not detected" "Not detected" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "basophil: 1.1" "Lineage enriched" "Detected in single" 5 "granulocytes: 1.1" "Cell line enhanced" "Detected in some" "Karpas-707: 1.5;SCLC-21H: 1.1" "Secreted in other tissues" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 2: Karpas-707 - Immune response" "Cluster 9: Photoreceptor cells - Phototransduction" "unprognostic (2.92e-2)" "unprognostic (1.90e-2)" "unprognostic (1.64e-1)" "unprognostic (1.47e-2)" "unprognostic (2.16e-3)" "unprognostic (1.96e-1)" "unprognostic (1.82e-1)" "unprognostic (6.38e-2)" "unprognostic (3.67e-1)" "unprognostic (1.97e-1)" "unprognostic (2.04e-1)" "unprognostic (2.18e-1)" "unprognostic (2.61e-4)" "unprognostic (1.89e-1)" "unprognostic (8.41e-2)" "unprognostic (6.38e-3)" "unprognostic (1.11e-1)" 0.6 0.0 0.3 0.0 0.4 0.3 0.2 0.6 0.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.2 0.1 0.1 0.4 0.1 0.0 0.1 0.0 0.1 0.1 0.5 0.1 0.6 24.8 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.1 0.0 0.0 0.1 1.5 0.1 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.3 0.0 1.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.3 0.0 0.0 0.1 0.2 0.0 1.1 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.9 0.1 0.1 0.0 0.0 0.3 0.3 0.4 0.6 0.6 0.4 0.0 0.4 0.1 0.5 0.0 0.1 0.3 0.1 0.0 1.8 3.9 0.5 0.3 0.7 0.1 0.6 8.3 0.1 0.0 2.1 0.0 0.7 1.8 316.9 0.8 0.2 0.0 0.0 0.4 87.3 1.0 1.0 0.7 20.3 0.0 22.0 0.4 0.4 0.7 0.0 2.1 2.5 0.0 0.0 0.3 0.1 10.1 83.8 0.4 0.0 0.0 0.6 45.7 0.9 0.2 0.0 3.7 0.1 4.0 0.0 5.5 12.9 0.3 0.0 0.7 0.1 0.2 0.1 0.3 0.1 140.2 0.0 1.5 0.3 2.6 1.3 0.4 0.1 1.1 0.6 0.3 0.2 0.2 FA2H "FAAH, FAXDC1, FLJ25287, SPG35" ENSG00000103089 "Fatty acid 2-hydroxylase" Q7L5A8 16 74712955-74774831 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Sphingolipid metabolism" Oxidoreductase "Disease variant, Hereditary spastic paraplegia, Leukodystrophy, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 183.9;stomach 1: 61.1" "Cell type enhanced" "Detected in many" "Gastric mucus-secreting cells: 85.1;Oligodendrocyte precursor cells: 61.3;Oligodendrocytes: 307.9;Paneth cells: 75.2;Urothelial cells: 192.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 38.1;HAP1: 48.6;JURKAT: 89.8;OE19: 61.5;SK-BR-3: 28.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA056614, HPA077840" Approved Uncertain "Nuclear membrane" NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 70: Brain - Nervous system development" "Cluster 21: OE19 - Mitochondria" "Cluster 22: Epithelial cell types - Mixed function" "Nuclear membrane" "HPA056614: AB_2683191, HPA077840: AB_2686858" "unprognostic (1.33e-1)" "unprognostic (4.97e-2)" "unprognostic (9.19e-2)" "unprognostic (1.08e-1)" "unprognostic (1.60e-1)" "unprognostic (5.85e-2)" "unprognostic (1.48e-2)" "unprognostic (2.47e-2)" "unprognostic (1.82e-1)" "unprognostic (1.28e-1)" "prognostic unfavorable (3.74e-4)" "unprognostic (6.01e-2)" "prognostic favorable (5.01e-6)" "unprognostic (1.50e-1)" "unprognostic (1.76e-1)" "unprognostic (1.83e-2)" "unprognostic (2.11e-3)" 0.3 0.3 41.7 4.3 89.1 0.3 2.8 77.9 63.0 1.9 11.7 21.2 10.3 0.2 2.2 7.9 1.8 17.8 0.3 46.1 56.1 8.2 0.2 1.4 0.7 129.2 79.6 0.0 8.4 10.1 0.6 0.7 106.0 1.9 19.4 0.4 11.0 0.7 0.0 8.5 14.4 1.1 65.2 0.5 61.1 2.9 75.2 4.7 2.0 0.1 5.9 26.3 2.2 183.9 9.2 38.1 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.5 0.0 20.8 21.0 0.0 0.2 0.0 2.0 3.6 48.6 0.6 0.1 0.0 1.6 0.0 2.7 0.0 0.0 0.0 0.2 0.0 0.1 0.1 0.1 0.0 0.0 89.8 0.0 0.0 0.0 15.2 0.8 0.0 0.9 61.5 2.1 0.0 0.0 1.6 23.4 15.6 6.5 0.0 0.0 28.8 0.0 1.3 8.6 0.0 0.0 0.0 0.1 0.0 0.2 1.4 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 41.7 89.1 77.9 63.0 46.1 56.1 129.2 79.6 106.0 65.2 75.2 183.9 0.0 0.0 1.3 1.0 2.6 0.5 11.1 8.5 1.8 0.0 5.0 3.3 0.2 8.6 14.6 0.0 0.0 0.5 0.2 43.0 7.9 13.5 10.8 2.4 0.5 0.2 6.7 0.0 0.7 14.2 0.2 1.1 85.1 4.5 0.0 0.1 0.0 0.0 0.1 0.0 0.9 34.8 4.1 0.0 0.0 4.0 0.0 0.2 3.6 0.0 0.0 0.0 0.0 61.3 307.9 38.4 75.2 0.4 6.2 22.9 17.6 0.2 10.5 0.0 0.0 0.0 0.6 2.4 3.3 12.4 0.9 0.1 0.2 0.0 15.3 192.8 FAM161A "FLJ13305, RP28" ENSG00000170264 "FAM161 centrosomal protein A" Q3B820 2 61824848-61854143 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cilium biogenesis/degradation, Sensory transduction, Vision" "Ciliopathy, Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "retina: 28.9" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 100.1;Early spermatids: 183.2;Late spermatids: 293.1;Rod photoreceptor cells: 417.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA032119 Approved NA Yes "Cluster 49: Eosinophils - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA032119: AB_10602806" "unprognostic (1.14e-1)" "unprognostic (1.36e-1)" "unprognostic (4.23e-2)" "prognostic unfavorable (9.02e-4)" "unprognostic (1.73e-1)" "unprognostic (2.16e-1)" "unprognostic (1.56e-5)" "unprognostic (7.62e-2)" "unprognostic (1.72e-1)" "unprognostic (2.14e-2)" "unprognostic (4.35e-2)" "unprognostic (2.00e-2)" "unprognostic (1.66e-1)" "unprognostic (5.33e-2)" "unprognostic (3.93e-1)" "unprognostic (8.08e-3)" "unprognostic (7.04e-2)" 0.9 1.2 0.8 0.5 1.1 0.3 1.1 0.6 1.6 2.1 2.4 1.0 0.4 1.6 1.2 1.1 4.0 1.4 1.5 0.9 1.1 1.9 0.7 1.0 0.7 0.8 0.9 5.2 2.3 1.9 2.4 1.1 0.8 1.0 0.6 28.9 0.7 1.1 1.2 0.6 0.7 0.6 0.6 0.7 2.6 5.5 1.0 1.6 3.6 0.3 0.6 1.1 1.1 0.9 3.4 3.1 7.1 3.3 3.4 3.2 2.1 2.9 1.5 3.4 4.2 2.1 1.7 6.6 1.5 0.5 6.1 1.6 4.3 0.5 8.0 4.5 4.7 2.4 2.8 3.3 2.9 2.7 0.5 1.3 0.0 6.6 1.9 4.0 3.7 6.4 0.9 2.5 2.4 1.3 4.9 5.2 11.0 4.2 3.3 8.4 12.1 3.3 2.4 0.8 8.7 7.3 6.2 0.8 4.7 6.7 1.5 1.8 0.7 5.9 5.2 4.2 6.7 3.8 3.1 8.1 4.2 4.5 1.2 0.0 0.0 0.3 0.0 0.0 0.1 0.1 0.4 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.0 0.1 0.2 0.0 0.8 1.1 0.6 1.6 0.9 1.1 0.8 0.9 0.8 0.6 1.0 0.9 3.9 3.2 9.7 20.2 3.7 5.5 9.4 10.2 6.2 49.7 4.8 7.0 14.5 7.2 10.5 20.2 100.1 14.0 2.3 1.5 1.9 4.3 183.2 42.7 11.0 6.7 6.0 5.5 16.6 3.8 7.7 10.7 5.1 4.8 4.5 42.7 4.2 3.8 3.6 16.8 19.0 2.5 14.2 1.2 3.6 293.1 20.8 2.3 8.8 4.7 2.0 42.4 2.1 11.1 33.0 1.3 0.3 16.6 4.0 4.7 0.0 13.0 47.1 417.2 0.0 14.2 9.0 98.0 39.3 5.3 4.1 11.1 3.6 16.4 3.5 3.4 FARS2 "dJ236A3.1, FARS1, mtPheRS" ENSG00000145982 "Phenylalanyl-tRNA synthetase 2, mitochondrial" O95363 6 5261044-5829192 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Protein biosynthesis" "Aminoacyl-tRNA synthetase, Ligase" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 4 "Astrocytes: 110.4;Early spermatids: 77.4;Excitatory neurons: 217.0;Inhibitory neurons: 122.6;Late spermatids: 78.8;Microglial cells: 106.8;Oligodendrocyte precursor cells: 186.5;Oligodendrocytes: 122.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018148, HPA028836" Approved NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 8: Non-specific - Mitochondria" "Cluster 44: HDLM-2 - Immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA018148: AB_1848426, HPA028836: AB_10601377" "unprognostic (2.73e-1)" "unprognostic (4.08e-3)" "prognostic favorable (5.14e-4)" "unprognostic (2.68e-1)" "unprognostic (1.94e-2)" "unprognostic (5.34e-3)" "unprognostic (1.82e-1)" "unprognostic (4.31e-3)" "unprognostic (7.18e-2)" "unprognostic (1.02e-2)" "unprognostic (8.91e-2)" "unprognostic (2.50e-1)" "prognostic favorable (1.24e-6)" "unprognostic (2.81e-2)" "unprognostic (2.83e-1)" "unprognostic (2.02e-2)" "unprognostic (1.57e-1)" 9.4 12.0 8.1 9.6 10.9 11.7 11.0 6.1 10.8 8.8 22.9 10.6 7.4 9.2 7.3 9.8 14.9 6.8 16.0 8.4 9.6 14.2 14.4 9.6 12.4 5.8 6.7 7.8 10.3 13.2 9.8 8.9 6.5 7.3 11.3 6.8 8.4 8.6 19.7 11.4 7.9 9.8 6.1 9.8 9.9 11.7 10.8 12.5 14.4 17.9 11.0 8.8 8.9 8.6 14.2 13.4 14.1 14.7 17.1 20.5 11.6 15.1 17.9 19.4 19.2 18.0 10.7 19.7 23.1 14.9 18.9 13.9 18.2 23.9 20.2 59.5 12.2 7.9 11.0 16.1 8.9 18.9 11.4 16.5 24.0 21.9 15.8 11.4 23.6 21.8 23.7 4.5 14.6 14.5 20.6 21.2 8.7 21.7 12.9 20.0 17.6 38.9 18.7 16.4 23.9 11.8 14.1 11.0 17.6 18.4 22.1 20.6 13.7 20.7 9.4 12.3 19.8 9.3 34.2 10.9 11.6 11.1 26.6 0.1 14.7 5.2 23.1 16.7 20.3 20.0 20.5 21.2 26.0 17.5 22.3 22.1 1.1 24.6 11.9 15.5 28.0 17.6 8.1 10.9 6.1 10.8 8.4 9.6 5.8 6.7 6.5 6.1 10.8 8.6 10.4 9.6 13.7 110.4 15.7 14.8 18.5 17.7 10.2 8.8 8.9 12.1 18.4 12.8 8.5 9.2 2.1 19.5 10.5 6.9 27.4 14.6 77.4 10.2 7.6 10.9 10.7 13.9 217.0 12.9 20.9 10.5 13.3 7.2 22.2 14.3 11.4 12.0 15.8 0.0 122.6 9.4 14.2 12.5 11.6 78.8 6.2 17.4 5.4 106.8 9.4 14.2 8.2 186.5 122.4 7.8 8.6 7.2 16.1 6.6 7.4 30.7 19.3 11.1 0.0 10.1 10.8 19.2 9.4 13.3 13.2 10.7 16.2 24.2 11.9 13.2 FAT2 "CDHF8, CDHR9, HFAT2, MEGF1" ENSG00000086570 "FAT atypical cadherin 2" Q9NYQ8 5 151504093-151568944 "Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins" "Cell adhesion" "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 113.4;esophagus: 50.9;skin 1: 56.0" "Cell type enhanced" "Detected in some" "Basal keratinocytes: 18.0;Basal respiratory cells: 31.6;Basal squamous epithelial cells: 27.9;Early spermatids: 16.0;Extravillous trophoblasts: 20.6;Squamous epithelial cells: 53.2;Suprabasal keratinocytes: 19.6" "Group enriched" "Detected in many" 6 "cervical cancer: 13.9;head and neck cancer: 21.4;lung cancer: 6.1;urothelial cancer: 5.6" "Region enriched" "Detected in many" 7 "cerebellum: 113.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "BEWO: 35.1;EFO-21: 21.0;HaCaT: 51.7;HBEC3-KT: 23.6;hTCEpi: 70.5" "Region enriched" "Detected in some" 18 "cerebellum: 32.0" "Region enriched" "Detected in many" 56 "cerebellum: 224.4" CAB033680 Enhanced NA NA 300000 "Cluster 27: Brain & Skin - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 61: Squamous epithelial cells - Keratinization" "CAB033680: AB_2100956" "unprognostic (8.06e-3)" "unprognostic (6.01e-2)" "unprognostic (3.47e-1)" "unprognostic (4.80e-3)" "unprognostic (1.33e-1)" "unprognostic (4.43e-1)" "unprognostic (9.78e-3)" "unprognostic (2.28e-1)" "unprognostic (8.25e-2)" "unprognostic (2.65e-1)" "unprognostic (2.96e-2)" "unprognostic (1.90e-1)" "unprognostic (1.84e-7)" "unprognostic (2.38e-1)" "unprognostic (1.47e-1)" "unprognostic (6.77e-2)" "unprognostic (3.64e-3)" 0.4 0.2 0.4 0.0 3.8 0.1 3.6 113.4 4.8 11.5 0.0 0.1 0.1 0.1 1.7 50.9 1.0 0.0 0.1 0.5 0.4 0.6 0.1 0.2 0.0 15.1 2.8 0.1 0.2 0.2 0.5 0.9 17.2 5.3 0.0 0.1 8.9 4.8 0.2 56.0 0.2 0.0 0.4 0.1 0.1 13.2 0.5 2.2 0.1 0.0 3.4 2.9 24.4 2.2 1.7 0.0 0.0 0.1 0.0 0.0 35.1 0.2 0.0 0.0 0.0 0.1 0.0 0.1 21.0 0.0 0.2 51.7 0.0 23.6 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.1 0.1 0.0 70.5 0.0 3.8 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.8 0.7 0.1 0.0 0.1 1.1 0.2 0.5 0.0 0.0 0.1 0.1 0.4 0.0 0.1 0.0 0.0 1.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 3.8 113.4 4.8 0.5 0.4 15.1 2.8 17.2 0.4 0.5 2.2 0.1 0.0 0.0 0.7 0.0 18.0 5.8 31.6 27.9 0.0 3.4 12.8 1.9 0.0 11.1 1.8 0.0 0.4 0.0 0.0 0.0 0.0 16.0 0.1 0.0 0.3 0.0 0.0 5.0 0.0 20.6 0.3 0.0 0.7 0.0 0.0 0.0 0.0 0.8 0.0 2.9 0.0 0.0 0.0 1.5 7.8 0.0 0.0 7.2 0.0 0.0 0.0 0.0 4.0 0.9 0.0 0.0 0.0 0.0 1.2 0.0 0.1 3.0 0.0 0.0 0.0 0.4 0.5 0.1 53.2 19.6 1.0 0.1 0.0 0.0 13.0 FBLN5 "ARMD3, DANCE, EVEC, UP50" ENSG00000140092 "Fibulin 5" Q9UBX5 14 91869411-91947987 "Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Cell adhesion" "Age-related macular degeneration, Charcot-Marie-Tooth disease, Disease variant, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in many" 6 "Fibroblasts: 209.4;Leydig cells: 626.6;Peritubular cells: 794.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "basophil: 6.6" "Group enriched" "Detected in many" 19 "granulocytes: 6.6;T-cells: 1.8" "Cell line enhanced" "Detected in many" "ASC diff: 457.1;ASC TERT1: 234.6;BJ: 202.0;BJ hTERT+: 202.5;fHDF/TERT166: 394.6;HSkMC: 216.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000848, HPA000868, CAB025843" Supported Uncertain "Plasma membrane" "Secreted to extracellular matrix" NA NA 12000000 "Cluster 46: Basophils - DNA binding" "Cluster 82: Adipose tissue - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane" "CAB025843: , HPA000848: AB_1078620, HPA000868: AB_1078619" "unprognostic (5.53e-3)" "unprognostic (1.14e-1)" "unprognostic (7.78e-2)" "unprognostic (9.29e-2)" "unprognostic (5.55e-3)" "unprognostic (4.73e-2)" "prognostic favorable (6.75e-4)" "unprognostic (5.21e-3)" "unprognostic (4.76e-2)" "unprognostic (1.25e-2)" "unprognostic (3.74e-2)" "unprognostic (1.90e-1)" "unprognostic (7.26e-2)" "unprognostic (1.56e-3)" "unprognostic (1.73e-1)" "unprognostic (5.18e-2)" "unprognostic (3.17e-3)" 182.2 73.4 10.7 17.7 12.8 7.5 110.4 7.4 12.5 124.9 15.7 80.3 19.1 178.4 40.0 26.8 143.0 130.2 211.1 9.4 8.6 108.4 29.3 164.8 25.5 15.5 10.9 107.3 46.4 16.8 14.5 67.0 14.2 49.0 20.6 0.6 55.8 70.9 30.4 66.9 52.7 88.7 13.1 130.9 68.9 35.6 12.7 21.8 79.5 36.0 15.7 117.5 93.3 7.5 0.0 1.6 0.2 0.0 457.1 234.6 22.5 202.0 202.5 5.8 4.5 4.7 0.0 0.0 4.2 394.6 0.6 0.1 9.8 1.0 1.0 0.0 2.3 0.4 4.7 0.0 74.2 0.0 0.1 216.6 0.4 3.9 14.1 2.8 10.4 0.1 0.0 0.1 25.3 0.4 0.5 0.5 0.5 0.0 0.5 0.4 30.2 0.2 1.2 0.1 0.2 0.1 12.3 0.7 2.6 7.0 2.9 0.3 1.9 3.2 6.6 3.8 0.1 0.1 0.0 0.2 0.4 0.0 0.0 6.6 0.1 2.2 0.8 0.2 0.5 0.0 0.3 0.1 0.0 0.1 1.1 1.8 2.5 0.0 0.2 0.0 0.1 0.4 10.7 12.8 7.4 12.5 9.4 8.6 15.5 10.9 14.2 13.1 12.7 7.5 31.4 83.3 13.1 0.0 2.1 9.2 2.4 7.1 1.8 0.0 11.2 9.3 5.2 0.0 11.5 5.5 0.0 2.5 2.5 0.1 5.9 4.7 5.9 13.3 67.4 15.2 0.0 0.4 2.6 4.7 2.5 209.4 2.0 12.0 2.5 1.8 34.2 0.4 7.8 0.0 3.6 0.1 18.3 2.5 18.4 27.5 626.6 5.8 21.4 15.9 1.6 0.0 8.2 5.0 2.3 2.2 0.0 794.8 0.7 1.3 0.0 32.5 21.4 0.0 6.6 28.0 14.5 3.0 2.8 1.3 8.7 3.7 15.5 3.5 0.4 1.2 FBXO38 "Fbx38, FLJ13962, MOKA, SP329" ENSG00000145868 "F-box protein 38" Q6PIJ6 5 148383935-148442836 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Adaptive immunity, Immunity, Ubl conjugation pathway" "Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034821, HPA041444" Approved Supported "Nucleoplasm,Plasma membrane,Cytokinetic bridge,Cytosol" Yes No "Cluster 8: Neutrophils - Inflammatory response" "Cluster 8: Non-specific - Mitochondria" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 59: Non-specific - Transcription" "Nucleoplasm, Plasma membrane" "Cytokinetic bridge, Cytosol" "HPA034821: AB_10669897, HPA041444: AB_2677484" "unprognostic (7.72e-2)" "unprognostic (5.75e-3)" "unprognostic (1.95e-2)" "unprognostic (1.67e-1)" "unprognostic (2.21e-1)" "unprognostic (2.70e-2)" "unprognostic (7.06e-2)" "unprognostic (5.43e-3)" "unprognostic (1.45e-1)" "unprognostic (1.12e-1)" "unprognostic (2.03e-1)" "unprognostic (6.29e-2)" "unprognostic (2.21e-3)" "unprognostic (1.31e-3)" "unprognostic (1.83e-1)" "unprognostic (1.64e-1)" "unprognostic (4.70e-3)" 12.8 11.5 7.3 12.9 8.4 9.8 13.9 8.1 9.9 14.1 8.2 12.5 9.6 12.5 11.1 10.5 10.0 11.5 17.4 7.0 7.7 12.9 18.0 14.5 14.6 8.0 7.6 12.3 9.5 18.5 10.2 13.8 8.0 14.6 13.0 11.0 11.5 12.0 18.7 12.2 11.6 12.3 7.5 14.4 12.5 12.4 7.8 20.2 12.2 16.8 15.6 13.8 11.2 9.9 12.6 13.2 20.1 14.7 22.1 24.6 10.4 16.1 30.7 22.4 30.5 19.6 15.1 18.2 15.5 26.2 23.6 17.2 21.2 20.3 26.8 20.1 13.6 10.8 19.0 13.3 21.9 29.6 17.0 24.0 17.1 21.6 21.1 24.0 30.7 16.6 12.2 19.1 22.3 5.1 18.8 13.8 9.4 13.9 19.8 16.6 29.3 18.4 21.7 14.5 17.9 17.3 21.4 14.2 21.2 17.1 15.0 21.2 20.2 20.4 7.3 10.8 18.2 23.3 25.1 15.3 20.3 16.6 15.8 15.1 6.1 9.1 5.0 8.0 5.5 4.9 4.7 5.0 7.5 3.8 4.8 6.2 11.2 7.7 15.2 3.7 7.4 4.9 7.3 8.4 8.1 9.9 7.0 7.7 8.0 7.6 8.0 7.5 7.8 9.9 10.6 16.0 45.7 25.1 13.8 3.3 5.5 7.4 7.4 10.3 8.5 6.7 18.7 11.5 10.6 11.0 10.4 7.5 13.4 11.3 5.9 8.8 11.2 8.9 9.9 10.8 9.6 7.2 40.2 6.7 6.8 11.8 14.8 10.4 15.8 9.6 11.4 16.9 12.6 13.5 37.4 10.1 6.1 24.9 6.4 2.9 9.0 17.8 3.6 38.4 12.3 5.9 12.3 33.2 44.4 9.9 8.9 18.4 11.0 8.6 9.3 9.3 16.4 9.0 0.0 6.9 7.8 20.6 8.6 9.2 3.8 12.3 12.1 11.2 9.0 8.7 FBXO7 "Fbx, FBX7, PARK15" ENSG00000100225 "F-box protein 7" Q9Y3I1 22 32474676-32498829 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Ubl conjugation pathway" "Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 279.9" "Cell type enhanced" "Detected in all" "Erythroid cells: 680.9;Late spermatids: 620.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA032113, HPA032114, CAB034296" Uncertain Supported Nucleoplasm,Cytosol NA NA 550000 "Cluster 2: Granulocytes - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 6: Erythroid cells - Oxygen transport" "Nucleoplasm, Cytosol" "CAB034296: AB_2102563, HPA032113: AB_2674156, HPA032114: AB_10696202" "unprognostic (3.99e-2)" "unprognostic (1.53e-1)" "prognostic favorable (1.08e-5)" "unprognostic (1.36e-1)" "unprognostic (2.82e-1)" "unprognostic (2.11e-2)" "unprognostic (1.79e-1)" "unprognostic (1.29e-1)" "unprognostic (1.03e-1)" "unprognostic (2.45e-2)" "unprognostic (2.28e-1)" "unprognostic (2.53e-1)" "prognostic favorable (2.66e-10)" "unprognostic (3.33e-2)" "unprognostic (1.65e-1)" "unprognostic (7.02e-2)" "unprognostic (1.79e-3)" 51.6 61.7 70.3 35.9 86.8 279.9 52.9 79.9 86.5 53.5 72.3 53.5 47.7 49.2 68.7 40.1 66.6 43.9 38.5 68.3 76.2 106.5 128.4 59.6 54.6 85.0 83.8 62.7 41.0 75.9 50.6 71.5 84.1 42.6 53.8 40.1 43.1 53.5 31.0 50.6 48.4 57.1 79.0 65.6 48.4 99.5 79.8 77.9 134.2 48.3 61.8 54.8 44.0 97.8 72.1 52.1 69.3 77.1 105.8 99.5 45.9 64.3 119.6 102.7 121.9 54.4 51.1 71.2 49.6 114.6 87.8 47.6 103.3 84.7 105.1 111.8 80.9 99.1 54.4 83.7 126.8 126.2 82.8 83.8 134.1 90.6 69.2 93.4 112.2 53.1 77.5 88.0 112.7 57.7 65.3 81.2 26.7 102.3 36.1 64.1 72.2 84.0 118.2 81.0 96.6 63.1 81.3 62.4 235.2 98.3 34.0 67.2 76.0 50.6 69.4 48.4 49.5 62.1 69.3 67.6 97.4 65.6 212.3 251.5 59.9 132.1 83.3 70.6 101.5 70.2 75.9 84.9 82.2 63.6 65.6 72.6 22.4 98.3 74.9 55.8 101.3 90.4 70.3 86.8 79.9 86.5 68.3 76.2 85.0 83.8 84.1 79.0 79.8 97.8 48.8 41.7 25.3 37.9 60.4 46.3 69.4 72.7 48.9 26.0 46.5 32.3 16.1 65.8 48.1 49.7 18.8 90.2 73.6 43.4 97.8 75.3 303.3 41.3 37.8 53.1 67.6 680.9 27.6 77.4 108.9 47.9 40.2 47.2 55.8 63.6 53.9 88.6 71.9 33.7 26.7 42.7 65.1 64.8 53.2 620.8 45.1 55.0 119.2 28.1 125.2 54.1 72.1 101.0 170.6 77.2 58.0 48.9 62.7 68.3 72.2 152.9 34.2 38.1 46.0 35.3 46.2 149.4 136.9 42.3 43.3 71.6 62.3 41.8 47.2 83.7 FDXR "ADR, ADXR" ENSG00000161513 "Ferredoxin reductase" P22570 17 74862497-74873031 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cholesterol metabolism, Electron transport, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transport" Oxidoreductase "Deafness, Disease variant, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "adrenal gland: 343.1" "Group enriched" "Detected in many" 7 "Granulosa cells: 329.3;Theca cells: 794.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "BEWO: 89.5;Hep G2: 173.5" "Low region specificity" "Detected in all" "CAB008597, CAB009818, HPA044393, HPA053673" Enhanced Enhanced Mitochondria NA NA "Cluster 15: NK-cells - Transcription" "Cluster 17: Adrenal gland - Steroid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 52: Non-specific - Transcription" Mitochondria "CAB008597: AB_1615557, CAB009818: AB_2102601, HPA044393: AB_2678927, HPA053673: AB_2682225" "unprognostic (2.69e-2)" "unprognostic (1.17e-3)" "unprognostic (7.51e-2)" "prognostic favorable (2.38e-4)" "unprognostic (3.43e-2)" "unprognostic (1.20e-1)" "unprognostic (1.53e-1)" "unprognostic (1.68e-2)" "unprognostic (2.29e-1)" "unprognostic (1.50e-1)" "unprognostic (1.09e-1)" "unprognostic (6.30e-2)" "unprognostic (1.42e-2)" "unprognostic (1.19e-2)" "unprognostic (4.50e-2)" "unprognostic (4.03e-2)" "unprognostic (2.13e-1)" 3.9 343.1 6.9 2.4 8.4 2.2 3.8 7.8 8.1 7.8 8.6 9.7 4.6 6.7 5.1 26.0 12.9 4.1 6.0 6.6 6.7 6.5 14.9 5.3 2.9 7.6 7.9 20.5 12.9 5.9 4.1 3.0 7.5 6.7 3.2 0.5 7.1 4.4 7.7 16.4 5.6 2.3 7.4 33.9 7.6 45.6 7.0 4.7 6.0 1.7 2.5 6.2 10.5 7.5 12.5 65.6 9.6 10.8 6.8 9.1 89.5 14.8 15.9 8.6 17.1 18.3 10.8 29.6 2.6 6.2 4.8 24.9 6.9 18.4 2.5 27.9 15.2 22.6 10.6 173.5 19.0 5.0 75.1 29.2 20.3 9.1 3.1 7.0 43.9 10.9 36.1 4.8 13.4 53.4 19.7 10.6 5.5 11.8 14.5 10.6 16.4 16.2 7.1 21.0 5.2 12.1 10.0 21.7 11.2 10.9 47.4 4.7 20.5 5.9 51.9 9.4 7.4 12.7 2.3 6.5 16.1 7.7 20.6 1.7 6.0 5.0 5.6 4.5 5.0 4.8 5.1 6.8 7.3 2.4 4.4 5.4 2.0 10.3 3.4 1.4 15.4 5.2 6.9 8.4 7.8 8.1 6.6 6.7 7.6 7.9 7.5 7.4 7.0 7.5 4.0 3.2 3.9 7.5 8.2 9.7 17.8 42.6 17.1 4.9 6.6 8.4 3.8 5.7 23.3 9.2 4.2 53.2 2.8 18.6 5.9 11.1 6.5 28.2 4.3 4.6 7.1 4.0 1.4 7.9 18.9 12.9 13.7 3.5 5.7 329.3 12.5 13.9 23.1 3.3 2.2 13.1 36.7 6.2 2.7 14.9 5.9 4.6 5.4 1.0 3.9 11.4 8.2 3.0 1.3 9.0 16.9 4.5 7.1 5.2 24.9 21.7 73.6 5.1 0.0 6.2 18.3 6.3 6.1 33.7 18.2 46.1 8.6 794.1 20.3 17.4 FGA ENSG00000171560 "Fibrinogen alpha chain" P02671 4 154583128-154590745 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted secreted proteins" "Adaptive immunity, Blood coagulation, Hemostasis, Immunity, Innate immunity" "Amyloidosis, Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 388 "liver: 18396.9" "Cell type enriched" "Detected in some" 41 "Hepatocytes: 17365.8" "Cancer enriched" "Detected in many" 43 "liver cancer: 2431.6" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 15 "Hep G2: 429.3" "Not detected" "Not detected" "Not detected" "Not detected" "CAB016776, HPA051370, HPA064755" Supported Enhanced "Endoplasmic reticulum" "Secreted to blood" NA NA 407000000 140000000000 "Cluster 62: Liver - Hemostasis" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 15: Hepatocytes - Hemostasis" "Endoplasmic reticulum" "CAB016776: , HPA051370: AB_2681458, HPA064755: AB_2685345" "unprognostic (5.95e-2)" "unprognostic (6.25e-2)" "unprognostic (2.02e-1)" "unprognostic (5.68e-2)" "prognostic favorable (7.33e-4)" "unprognostic (1.29e-3)" "unprognostic (1.84e-1)" "prognostic unfavorable (4.23e-6)" "unprognostic (4.20e-1)" "unprognostic (1.41e-1)" 2.1 1.3 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.5 0.0 0.5 0.0 0.6 0.6 0.7 0.9 13.2 1.2 0.0 0.0 18.8 18396.9 5.3 0.1 0.0 0.0 0.7 18.8 0.0 0.5 0.9 0.0 0.4 0.0 0.0 0.5 0.0 0.5 0.6 0.9 0.0 0.0 9.9 47.4 3.7 0.0 0.1 0.4 0.0 0.1 0.6 0.7 0.0 0.0 28.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 24.1 0.0 2.7 0.2 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 3.4 0.1 429.3 0.0 6.3 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.1 0.2 0.0 0.5 0.1 0.0 0.5 6.1 0.0 0.0 0.5 0.2 0.1 3.5 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.3 0.0 0.0 1.0 0.0 1.9 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 20.4 0.0 27.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.5 414.6 3.2 0.0 0.0 0.0 0.0 0.0 1.9 38.6 28.3 0.1 0.2 8.1 0.0 205.9 0.0 1.8 0.1 0.1 1.1 1.3 0.0 0.0 238.8 17365.8 0.1 0.0 0.0 0.0 0.0 328.3 0.0 46.1 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.2 0.0 1.2 0.0 0.0 0.0 2.3 9.5 0.0 0.0 0.0 0.1 17.4 0.7 0.0 0.0 0.1 17.6 0.0 0.0 0.0 FGD4 "CMT4H, frabin, FRABP, ZFYVE6" ENSG00000139132 "FYVE, RhoGEF and PH domain containing 4" Q96M96 12 32399558-32646050 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Actin-binding, Guanine-nucleotide releasing factor" "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 232.5;Early spermatids: 196.3;Late spermatids: 250.1;Microglial cells: 203.3" "Cancer enhanced" "Detected in all" "testis cancer: 14.2" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in many" 4 "dendritic cells: 3.6;granulocytes: 8.4;monocytes: 5.7" "Cell line enhanced" "Detected in many" "ASC diff: 24.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039235 Approved Approved "Actin filaments" No No "Cluster 45: Eosinophils - Innate immune response" "Cluster 77: Retina - Visual perception" "Cluster 12: NES - Nervous system development" "Cluster 41: Macrophages - Immune response" "Actin filaments" "HPA039235: AB_10673420" "unprognostic (6.73e-2)" "unprognostic (2.55e-2)" "unprognostic (5.99e-2)" "unprognostic (2.64e-2)" "unprognostic (2.37e-1)" "unprognostic (5.45e-2)" "unprognostic (8.61e-3)" "unprognostic (3.91e-2)" "unprognostic (5.48e-2)" "unprognostic (2.19e-1)" "unprognostic (1.13e-3)" "unprognostic (2.79e-1)" "prognostic favorable (7.16e-5)" "unprognostic (9.50e-2)" "unprognostic (7.52e-2)" "unprognostic (1.17e-1)" "unprognostic (3.41e-3)" 12.6 4.3 8.1 5.6 10.3 12.1 8.0 11.4 6.7 6.1 13.8 9.4 8.8 2.3 2.9 7.4 4.9 10.3 5.3 7.4 10.3 10.8 17.7 8.1 1.8 12.3 10.1 24.6 9.4 14.8 3.1 10.4 12.4 4.6 10.1 23.6 6.7 4.0 10.8 7.4 8.2 3.4 9.2 5.2 28.9 12.1 9.5 1.7 6.3 10.8 2.7 4.0 5.9 13.7 5.4 2.6 6.6 2.0 24.1 14.8 8.1 4.5 22.5 1.2 0.4 8.1 8.3 0.8 2.5 0.3 2.8 5.1 5.3 7.5 0.7 0.7 2.6 4.7 2.7 2.5 4.3 0.9 0.0 8.8 10.3 6.0 12.9 3.3 11.6 1.1 0.5 5.4 15.6 1.9 0.0 1.7 17.4 5.3 0.2 0.4 6.9 16.2 8.0 5.3 7.2 8.5 4.7 4.4 6.6 11.8 7.0 0.3 13.1 0.1 1.5 18.8 0.7 1.9 4.6 2.9 0.0 2.8 5.2 3.6 3.8 8.4 0.2 5.7 0.2 0.6 0.3 0.2 3.6 1.4 0.2 0.3 5.5 0.7 5.1 0.4 0.2 1.3 8.1 10.3 11.4 6.7 7.4 10.3 12.3 10.1 12.4 9.2 9.5 13.7 84.3 48.1 31.4 232.5 5.6 8.4 11.3 12.1 8.6 23.8 10.7 7.5 19.2 54.3 18.3 22.0 118.9 1.3 0.5 57.8 13.7 16.8 196.3 36.0 8.1 24.8 19.2 4.4 40.5 20.7 16.8 19.9 78.5 65.7 2.5 34.1 9.3 37.7 11.8 70.7 55.1 31.2 26.4 71.7 22.3 250.1 4.7 92.9 14.2 203.3 39.9 79.3 1.0 25.1 95.1 33.5 29.3 1.5 16.4 16.4 54.8 15.0 15.3 114.5 52.6 16.5 41.3 10.4 7.4 25.0 12.6 1.4 3.1 25.6 30.5 20.2 FGF12 "FGF12B, FHF1" ENSG00000114279 "Fibroblast growth factor 12" P61328 3 192139390-192767764 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Growth factor" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 35.8;heart muscle: 131.3" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 413.7;Excitatory neurons: 1213.5;Inhibitory neurons: 1925.1;Oligodendrocyte precursor cells: 1668.3" "Cancer enhanced" "Detected in many" "glioma: 3.4" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 15.1;NTERA-2: 10.3;SCLC-21H: 23.9;U-251 MG: 14.7;WM-115: 17.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA071557 Approved Nucleoplasm,Cytosol NA NA "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm Cytosol "HPA071557: AB_2686417" "unprognostic (1.67e-3)" "unprognostic (1.29e-1)" "unprognostic (2.26e-2)" "unprognostic (2.50e-5)" "unprognostic (1.75e-1)" "unprognostic (5.66e-2)" "unprognostic (1.04e-1)" "unprognostic (1.80e-1)" "unprognostic (8.03e-2)" "unprognostic (2.11e-2)" "unprognostic (4.00e-2)" "unprognostic (9.19e-2)" "unprognostic (1.87e-7)" "unprognostic (2.41e-2)" "unprognostic (5.36e-2)" "unprognostic (5.59e-2)" "unprognostic (5.99e-2)" 1.9 35.8 8.5 0.2 14.1 0.0 1.3 0.5 21.3 0.5 0.0 1.1 0.7 1.0 0.2 1.7 1.5 0.5 131.3 17.5 14.2 2.5 0.6 1.1 0.2 11.1 1.0 0.8 7.7 1.6 5.3 0.4 9.9 1.3 0.3 15.4 5.9 6.0 1.1 0.3 0.3 0.7 0.0 11.6 0.6 2.1 3.5 0.1 1.5 0.8 0.2 0.5 0.7 2.8 0.1 1.1 15.1 0.0 0.0 0.0 0.1 0.0 0.1 1.4 1.7 0.0 0.1 0.8 7.2 0.3 0.3 0.2 0.0 0.0 1.6 0.1 0.2 3.2 6.3 0.0 0.0 0.0 0.9 0.0 0.2 0.0 0.0 3.7 0.2 0.0 0.1 0.1 0.0 4.4 0.0 0.0 10.3 7.1 0.3 0.0 0.1 0.0 4.7 1.8 23.9 0.0 0.0 0.6 0.0 1.7 1.1 0.2 0.4 6.2 3.2 0.0 14.7 0.2 2.5 0.0 1.3 0.0 17.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.5 14.1 0.5 21.3 17.5 14.2 11.1 1.0 9.9 0.0 3.5 2.8 17.8 0.0 0.0 42.7 0.1 0.6 4.2 0.0 0.6 100.2 0.9 1.7 413.7 0.0 1.9 5.5 4.2 0.2 0.0 0.0 7.9 0.7 20.9 1.6 1.6 13.2 0.0 0.0 1213.5 13.1 0.4 18.6 0.5 0.5 0.0 9.0 16.4 0.0 0.1 33.7 1925.1 0.0 0.0 0.3 0.3 38.5 6.8 0.1 1.8 46.9 0.0 3.8 0.0 1668.3 28.2 2.7 1.2 1.2 0.5 1.1 0.0 0.4 0.8 14.2 0.0 0.7 4.8 4.0 8.0 0.4 0.1 0.0 0.1 38.7 0.1 1.7 FGF14 "FHF4, SCA27" ENSG00000102466 "Fibroblast growth factor 14" Q92915 13 101710804-102402457 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Growth factor" "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 11.4;cervix: 7.3" "Group enriched" "Detected in many" 31 "Excitatory neurons: 1994.2;Inhibitory neurons: 2754.3;Oligodendrocyte precursor cells: 2271.0" "Cancer enhanced" "Detected in some" "glioma: 1.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "SCLC-21H: 1.0;SH-SY5Y: 5.8;U-87 MG: 1.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049828 Approved "Nucleoli fibrillar center" NA NA "Cluster 21: Non-specific - Transcription" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoli fibrillar center" "HPA049828: AB_2680901" "unprognostic (2.12e-1)" "unprognostic (1.57e-1)" "unprognostic (2.83e-2)" "unprognostic (2.27e-2)" "unprognostic (8.55e-2)" "unprognostic (1.28e-1)" "unprognostic (3.33e-1)" "unprognostic (1.81e-2)" "unprognostic (2.06e-1)" "unprognostic (8.22e-2)" "unprognostic (1.22e-1)" "unprognostic (2.45e-1)" "unprognostic (7.80e-3)" "unprognostic (2.20e-3)" "unprognostic (1.65e-1)" "unprognostic (3.86e-2)" "unprognostic (8.48e-2)" 0.5 1.2 3.2 0.0 2.6 0.0 0.3 11.4 5.1 7.3 0.0 0.2 0.1 0.1 0.4 0.5 2.7 0.4 1.5 2.5 7.7 0.1 0.4 1.4 0.0 2.2 1.1 0.1 0.3 0.0 3.3 0.1 2.2 0.1 0.1 1.6 0.3 0.1 0.1 0.4 0.4 0.0 1.6 0.0 0.7 1.0 4.5 0.0 0.2 0.1 0.0 0.2 0.5 2.1 0.1 0.0 0.5 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 1.0 5.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.2 0.2 0.0 0.2 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 2.6 11.4 5.1 2.5 7.7 2.2 1.1 2.2 1.6 4.5 2.1 0.5 3.2 1.5 74.4 0.0 0.5 0.5 0.2 2.2 33.2 0.3 1.8 7.4 2.8 8.2 0.0 0.0 0.0 0.3 0.1 0.0 0.3 18.3 4.4 0.4 0.3 19.2 0.0 1994.2 0.0 0.1 9.6 2.0 1.4 0.0 0.1 0.4 2.5 0.1 32.0 2754.3 1.0 6.1 0.0 0.0 35.2 2.5 0.1 1.8 36.5 0.0 5.2 3.1 2271.0 32.3 0.1 0.0 0.0 0.0 0.8 0.0 0.3 53.8 2.7 0.0 1.9 1.9 2.5 5.2 0.3 0.6 0.0 0.2 0.1 0.0 0.1 FIG4 "ALS11, CMT4J, dJ249I4.1, hSac3, KIAA0274, SAC3" ENSG00000112367 "FIG4 phosphoinositide 5-phosphatase" Q92562 6 109690609-109878098 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Hydrolase "Amyotrophic lateral sclerosis, Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 49.5;Oligodendrocyte precursor cells: 46.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017823, HPA068859" Approved Supported "Vesicles,Lipid droplets" NA NA "Cluster 37: B-cells - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Vesicles, Lipid droplets" "CAB017823: , HPA068859: AB_2686049" "prognostic unfavorable (5.91e-4)" "unprognostic (4.12e-2)" "prognostic favorable (8.42e-4)" "unprognostic (3.17e-2)" "unprognostic (1.66e-1)" "unprognostic (1.16e-1)" "prognostic unfavorable (4.73e-4)" "unprognostic (7.06e-2)" "unprognostic (2.69e-1)" "unprognostic (8.67e-2)" "unprognostic (3.44e-3)" "unprognostic (4.22e-2)" "prognostic favorable (8.19e-4)" "unprognostic (1.48e-1)" "unprognostic (2.02e-1)" "unprognostic (5.45e-2)" "unprognostic (2.00e-2)" 9.3 10.2 5.5 7.1 7.2 5.6 8.1 5.9 7.7 8.2 12.9 10.1 5.0 8.5 7.8 9.4 7.2 7.6 7.7 6.0 8.8 9.5 6.1 13.4 10.1 6.4 7.3 8.2 7.5 17.4 11.9 8.8 8.9 7.7 9.5 10.8 10.7 7.8 10.6 7.6 9.1 10.3 5.6 13.8 8.7 8.2 6.1 12.3 9.3 8.3 10.1 9.2 8.4 7.0 8.3 8.4 11.7 14.9 11.8 17.2 7.8 9.9 14.1 8.3 23.2 4.6 7.2 23.2 5.8 18.9 14.9 5.2 12.6 8.5 20.7 13.3 16.5 10.9 5.9 5.5 11.4 9.5 10.0 8.8 9.9 12.8 10.6 22.8 18.3 13.9 6.8 8.8 12.7 6.8 12.0 8.4 5.9 12.0 4.7 7.9 6.1 7.3 13.3 18.4 12.8 11.7 7.1 10.7 21.1 15.6 6.0 23.1 11.2 4.2 3.8 5.4 9.5 3.4 2.6 7.9 27.3 8.5 4.6 15.4 24.9 14.2 8.8 24.5 7.7 18.9 6.3 8.5 19.2 21.2 7.5 7.5 7.4 10.0 15.2 8.1 9.4 11.7 5.5 7.2 5.9 7.7 6.0 8.8 6.4 7.3 8.9 5.6 6.1 7.0 4.9 16.0 9.0 24.5 15.7 4.6 7.1 7.3 5.2 8.8 5.4 3.3 6.7 2.8 6.9 9.2 2.1 13.4 9.5 7.0 5.9 9.8 18.0 7.5 5.3 5.2 10.2 3.0 49.5 11.4 7.0 6.0 8.2 7.9 8.8 8.6 7.1 4.1 23.3 1.7 32.4 8.6 8.2 19.2 6.8 17.7 3.4 17.3 8.8 29.0 16.4 8.5 11.3 46.8 37.4 7.6 6.3 6.8 6.5 4.0 6.3 8.2 9.1 7.6 0.0 5.1 6.6 5.5 12.1 8.3 4.4 12.3 9.3 5.6 6.4 8.9 FLVCR1 "AXPC1, FLVCR, MFSD7B, PCA, SLC49A1" ENSG00000162769 "FLVCR heme transporter 1" Q9Y5Y0 1 212858275-212899363 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Erythrocyte maturation, Transport" Receptor "Disease variant, Neurodegeneration, Neuropathy, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 19.4" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 73.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in all" "NTERA-2: 55.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046646 Approved Approved "Cell Junctions" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 56: Intestine - Transmembrane transport" "Cluster 5: NTERA-2 - Transcription" "Cluster 45: Enterocytes - Digestion" "Cell Junctions" "HPA046646: AB_2679735" "unprognostic (2.09e-1)" "unprognostic (1.06e-1)" "unprognostic (1.83e-1)" "unprognostic (1.01e-1)" "unprognostic (2.83e-2)" "unprognostic (2.48e-1)" "prognostic unfavorable (2.52e-5)" "unprognostic (1.03e-1)" "unprognostic (1.21e-1)" "unprognostic (3.88e-2)" "prognostic favorable (3.50e-4)" "unprognostic (1.89e-1)" "prognostic unfavorable (1.06e-5)" "unprognostic (7.15e-2)" "unprognostic (2.25e-1)" "unprognostic (3.91e-2)" "unprognostic (7.29e-3)" 2.1 2.4 3.4 3.1 2.8 6.2 3.1 5.0 3.7 2.9 2.7 3.4 9.7 2.5 4.9 2.1 2.4 2.0 1.6 3.2 4.4 2.4 1.8 2.4 2.9 4.5 4.1 2.4 2.6 3.6 6.9 2.4 5.3 3.4 2.8 7.0 1.9 1.8 1.0 2.9 19.4 1.7 2.5 2.6 4.8 2.8 4.3 2.6 2.2 0.6 2.2 2.3 2.3 4.2 8.4 11.0 16.8 5.1 2.8 3.4 31.3 2.4 1.8 4.8 2.9 16.1 15.2 9.1 4.4 1.7 10.2 12.5 18.2 5.4 4.7 5.4 8.0 5.4 10.4 14.9 3.2 14.5 8.4 2.7 3.5 5.2 6.6 2.5 3.8 6.4 14.7 7.4 3.2 3.2 4.1 7.2 55.3 11.1 7.7 9.0 15.4 10.6 6.0 8.0 18.1 12.7 11.2 11.1 10.4 13.8 18.2 6.7 2.2 2.3 5.6 7.7 11.2 4.6 9.9 10.8 3.5 8.3 2.9 0.5 0.2 1.5 0.2 0.1 0.2 0.2 0.3 0.2 0.1 0.3 0.3 0.3 0.7 0.2 0.2 0.4 0.4 0.0 3.4 2.8 5.0 3.7 3.2 4.4 4.5 4.1 5.3 2.5 4.3 4.2 6.7 12.8 16.0 12.4 8.3 14.3 8.8 6.9 9.6 24.0 10.3 9.5 4.1 14.3 12.1 20.2 35.5 3.9 6.8 13.7 1.9 5.5 4.7 7.0 7.8 9.3 32.4 9.5 28.8 13.4 6.7 8.8 17.3 7.6 7.0 20.1 10.0 9.2 6.5 16.8 39.4 10.6 10.2 10.1 9.6 6.8 6.2 9.0 5.4 9.4 10.5 5.8 4.1 24.1 28.7 8.9 12.0 2.6 6.5 11.9 73.7 4.6 10.1 31.8 6.6 18.0 7.2 10.4 6.8 7.0 9.2 2.5 8.3 5.1 8.2 4.3 FOLR1 "FOLR, FRα" ENSG00000110195 "Folate receptor alpha" P15328 11 72189558-72196323 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins, Transporters" Transport Receptor Neurodegeneration "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 480.2;fallopian tube: 187.2;lung: 193.5;salivary gland: 219.5" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 496.8;Alveolar cells type 2: 213.3;Breast glandular cells: 211.3;Club cells: 276.3;Collecting duct cells: 318.2;Cytotrophoblasts: 462.2;Proximal tubular cells: 366.0;Syncytiotrophoblasts: 259.0" "Cancer enhanced" "Detected in many" "ovarian cancer: 259.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "HeLa: 444.2;RPTEC TERT1: 476.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA077030 Approved "Nuclear membrane" "Secreted to blood" NA NA 448000 140000 "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 30: Mammary glandular cells - Lactation" "Nuclear membrane" "HPA077030: " "unprognostic (3.30e-1)" "unprognostic (2.19e-1)" "unprognostic (6.55e-2)" "unprognostic (3.49e-2)" "unprognostic (7.67e-3)" "unprognostic (1.98e-2)" "prognostic unfavorable (2.50e-4)" "unprognostic (1.18e-2)" "unprognostic (8.13e-2)" "unprognostic (2.47e-2)" "unprognostic (2.58e-2)" "unprognostic (2.87e-3)" "unprognostic (1.67e-1)" "unprognostic (2.52e-1)" "unprognostic (1.11e-1)" "unprognostic (2.20e-1)" "unprognostic (2.69e-1)" 0.1 1.7 2.7 0.2 1.8 0.1 28.3 11.8 1.8 123.5 480.2 0.5 0.3 1.9 7.6 3.4 187.2 2.4 0.6 14.1 4.1 153.0 0.2 193.5 0.0 5.7 7.8 0.7 7.1 17.5 8.1 36.2 3.8 1.5 0.4 0.5 219.5 15.2 0.1 2.5 0.4 0.2 3.2 0.2 33.0 0.2 7.7 0.2 45.9 0.0 0.4 0.1 0.1 2.7 0.2 0.2 0.0 0.2 0.0 0.0 64.7 0.1 0.1 0.1 0.1 44.5 46.0 0.0 45.5 0.8 0.0 0.9 2.4 2.1 0.2 0.1 1.4 1.0 444.2 1.3 0.0 0.0 0.1 1.8 0.1 0.0 0.0 0.1 0.0 0.0 0.5 0.0 0.3 0.5 0.1 0.1 2.2 0.7 0.0 0.5 15.1 0.0 476.5 0.0 0.1 3.0 1.4 7.1 0.1 38.5 65.7 0.5 0.0 0.0 8.4 0.3 0.0 0.2 0.0 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 1.8 11.8 1.8 14.1 4.1 5.7 7.8 3.8 3.2 7.7 2.7 1.0 496.8 213.3 0.0 1.3 0.9 7.9 80.3 0.0 0.0 211.3 62.9 0.2 34.3 276.3 318.2 0.0 462.2 1.1 0.0 133.1 14.3 0.1 33.6 2.3 3.4 1.8 0.0 0.0 1.4 110.9 4.3 9.7 33.7 5.1 0.0 0.0 0.0 29.5 0.0 0.0 0.1 87.5 0.0 0.4 0.0 0.6 3.8 0.0 0.0 0.0 2.2 0.0 0.0 0.0 6.7 0.0 0.0 0.0 6.3 0.0 366.0 149.1 0.1 0.0 0.1 6.3 0.0 0.5 3.2 0.1 259.0 2.2 0.3 0.3 10.4 FOXE3 "FKHL12, FREAC8" ENSG00000186790 "Forkhead box E3" Q13461 1 47416285-47418052 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" DNA-binding "Aortic aneurysm, Cataract, Disease variant, Peters anomaly" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Group enriched" "Detected in some" 13 "Cardiomyocytes: 6.0;Spermatogonia: 2.3" "Group enriched" "Detected in some" 4 "cervical cancer: 0.5;testis cancer: 1.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 18 "SuSa: 10.1" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 12: NES - Nervous system development" "Cluster 43: Cardiomyocytes - Nuclear processes" "unprognostic (2.11e-1)" "unprognostic (1.31e-2)" "unprognostic (1.23e-3)" "unprognostic (1.32e-1)" "unprognostic (1.71e-1)" "unprognostic (6.24e-2)" "unprognostic (1.24e-2)" "unprognostic (8.21e-2)" "unprognostic (1.49e-1)" "unprognostic (2.34e-1)" "unprognostic (5.15e-2)" "unprognostic (1.04e-1)" "unprognostic (2.39e-7)" "unprognostic (2.41e-1)" "unprognostic (5.46e-2)" "unprognostic (3.60e-1)" 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 10.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.3 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 6.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 2.3 0.0 0.0 0.0 0.0 0.1 0.1 0.0 FRMD7 "FLJ43346, NYS, NYS1" ENSG00000165694 "FERM domain containing 7" Q6ZUT3 X 132076990-132128020 "Cancer-related genes, Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters" Neurogenesis "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "endometrium 1: 2.9;kidney: 2.7;smooth muscle: 2.2" "Cell type enriched" "Detected in single" 19 "Distal tubular cells: 9.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "U-87 MG: 1.5" "Region enriched" "Detected in many" 28 "olfactory bulb: 65.7" "Region enriched" "Detected in single" 86 "olfactory bulb: 21.3" HPA000886 Uncertain Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 1: Thyroid gland - Transcription" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 39: Non-specific - Basic cellular processes" "Plasma membrane, Cytosol" Nucleoplasm "HPA000886: AB_1079269" "unprognostic (3.08e-2)" "unprognostic (1.27e-1)" "unprognostic (1.36e-1)" "unprognostic (3.07e-1)" "unprognostic (4.02e-2)" "unprognostic (1.64e-2)" "unprognostic (2.28e-1)" "unprognostic (2.18e-2)" "unprognostic (3.84e-1)" "unprognostic (3.54e-2)" "unprognostic (3.00e-1)" 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.2 0.2 0.0 0.0 0.0 2.9 0.5 0.0 0.5 0.0 0.1 0.1 0.1 2.7 0.4 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.5 0.1 0.2 0.0 2.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.1 0.1 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 9.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 FRRS1L "C9orf4, CG-6" ENSG00000260230 "Ferric chelate reductase 1 like" Q9P0K9 9 109130293-109167249 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 18.6;ovary: 11.0" "Group enriched" "Detected in many" 4 "Bipolar cells: 59.1;Excitatory neurons: 91.6;Horizontal cells: 97.6;Inhibitory neurons: 81.3;Oligodendrocyte precursor cells: 27.6" "Cancer enhanced" "Detected in some" "glioma: 1.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 1.6;SH-SY5Y: 3.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA071086 Enhanced NA NA "Cluster 17: Basophils - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 62: Horizontal cells - Visual perception" "HPA071086: AB_2686342" "unprognostic (7.44e-2)" "unprognostic (1.90e-1)" "unprognostic (2.96e-2)" "unprognostic (2.21e-1)" "unprognostic (9.01e-2)" "unprognostic (3.10e-1)" "unprognostic (8.12e-2)" "unprognostic (1.84e-1)" "unprognostic (9.94e-2)" "unprognostic (1.51e-1)" "unprognostic (9.21e-4)" "unprognostic (7.35e-3)" "unprognostic (7.02e-2)" "unprognostic (5.78e-3)" "unprognostic (5.89e-2)" "unprognostic (2.85e-1)" "unprognostic (5.38e-3)" 0.1 7.8 15.1 0.3 16.6 0.3 0.3 9.2 17.3 1.3 0.0 0.7 0.4 1.5 2.8 1.9 1.4 1.0 1.0 18.6 15.4 0.1 0.1 0.2 0.2 2.5 6.3 11.0 0.6 3.0 7.2 0.0 6.2 3.1 0.3 7.8 0.2 1.7 0.1 0.2 0.5 1.5 6.9 0.2 0.8 0.7 15.4 0.0 0.2 0.1 0.1 0.1 0.2 7.1 0.0 0.2 1.6 0.0 0.2 0.1 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.7 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.6 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.4 0.1 0.2 0.1 0.0 0.0 15.1 16.6 9.2 17.3 18.6 15.4 2.5 6.3 6.2 6.9 15.4 7.1 0.1 3.2 0.6 1.3 0.1 0.4 1.5 0.0 0.6 59.1 0.7 0.4 5.0 0.0 0.6 0.0 2.1 0.4 1.5 1.6 0.0 0.0 7.9 3.2 1.6 0.8 1.2 0.0 91.6 0.0 0.2 4.3 0.0 1.8 1.3 16.3 0.4 0.1 0.1 97.6 81.3 0.8 0.0 0.6 1.2 4.6 13.1 0.5 1.8 4.7 0.2 16.6 0.0 27.6 5.9 0.1 0.4 17.0 0.0 1.1 4.1 0.1 0.0 7.0 0.0 1.6 1.5 0.3 1.2 0.0 0.6 0.3 0.3 10.8 1.3 0.8 FSCN2 "RFSN, RP30" ENSG00000186765 "Fascin actin-bundling protein 2, retinal" O14926 17 81528377-81537130 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Actin-binding "Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "pancreas: 4.5;retina: 8.7" "Group enriched" "Detected in some" 4 "Cone photoreceptor cells: 25.0;Exocrine glandular cells: 12.0;Rod photoreceptor cells: 25.7" "Cancer enhanced" "Detected in many" "thyroid cancer: 3.6" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "EFO-21: 1.9;T-47d: 2.0" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA079270 Enhanced NA NA "Cluster 77: Retina - Visual perception" "Cluster 6: T47d - Mammary gland" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA079270: " "unprognostic (3.50e-3)" "unprognostic (6.55e-2)" "unprognostic (2.73e-4)" "unprognostic (1.08e-3)" "unprognostic (1.11e-2)" "unprognostic (2.11e-2)" "unprognostic (6.49e-3)" "unprognostic (3.49e-1)" "unprognostic (1.64e-3)" "unprognostic (1.25e-2)" "unprognostic (1.20e-1)" "unprognostic (1.27e-1)" "unprognostic (3.21e-1)" "unprognostic (1.91e-1)" "unprognostic (1.53e-1)" "unprognostic (1.74e-1)" "unprognostic (2.11e-1)" 0.2 0.2 0.4 0.2 0.5 0.1 0.5 1.2 0.6 1.1 0.2 0.5 0.2 1.3 0.5 0.6 0.8 0.1 0.3 0.1 0.2 0.9 0.1 0.5 0.2 1.0 0.3 0.9 4.5 2.0 1.0 0.1 0.4 0.8 0.1 8.7 1.8 0.4 0.1 0.5 0.5 0.1 0.6 0.6 0.8 0.5 0.3 0.1 4.2 0.1 0.2 0.3 0.5 0.5 0.7 0.4 0.3 0.5 0.1 0.0 0.5 0.3 0.5 0.0 0.0 0.4 0.5 0.5 1.9 0.5 0.3 0.5 0.0 0.0 0.0 0.7 0.4 0.0 0.4 0.2 0.2 0.1 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.1 0.5 0.0 0.9 0.0 0.2 0.1 0.4 0.1 0.3 0.2 0.2 0.2 0.2 0.5 0.0 0.0 0.0 0.6 0.3 2.0 0.0 0.6 0.6 0.1 0.1 0.2 0.0 0.1 0.0 0.8 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.5 1.2 0.6 0.1 0.2 1.0 0.3 0.4 0.6 0.3 0.5 0.0 0.0 0.0 2.0 0.5 0.0 0.0 0.2 0.0 3.8 0.6 0.4 0.9 0.0 0.0 0.0 25.0 0.1 0.0 0.1 1.9 0.4 0.5 0.1 0.1 0.2 0.0 0.0 0.7 12.0 0.5 0.1 1.1 0.1 0.0 0.5 0.0 0.0 0.1 3.3 0.9 0.0 0.0 0.0 0.0 3.2 0.3 0.3 0.0 0.0 1.0 4.9 0.0 3.5 0.3 3.0 0.1 0.0 0.2 0.1 0.3 0.1 0.0 25.7 0.0 0.0 0.1 0.1 0.2 0.0 0.0 0.8 0.1 0.1 0.2 0.0 FTL "MGC71996, NBIA3" ENSG00000087086 "Ferritin light chain" P02792 19 48965309-48966879 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Iron storage" "Cancer-related genes, Cataract, Disease variant, FDA approved drug targets, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 14422.9" "Cell type enhanced" "Detected in all" "Hofbauer cells: 74983.4;Kupffer cells: 70127.1;Macrophages: 34584.5;Proximal tubular cells: 58047.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 5 "granulocytes: 125209.0;monocytes: 102128.9" "Cell line enhanced" "Detected in all" "HHSteC: 24796.9;HSkMC: 20811.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB020769, HPA041602" Enhanced Approved Cytosol NA NA 170000000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 4: Macrophages - Innate immune response" Cytosol "CAB020769: , HPA041602: AB_2677575" "unprognostic (2.95e-1)" "unprognostic (2.64e-2)" "unprognostic (1.31e-1)" "unprognostic (1.56e-3)" "unprognostic (7.48e-2)" "unprognostic (5.28e-2)" "unprognostic (2.16e-3)" "unprognostic (6.17e-3)" "unprognostic (1.18e-1)" "unprognostic (1.08e-1)" "unprognostic (2.66e-1)" "unprognostic (2.96e-1)" "prognostic unfavorable (4.40e-5)" "unprognostic (1.32e-1)" "unprognostic (2.43e-2)" "unprognostic (2.30e-2)" "unprognostic (1.87e-2)" 6778.7 3262.2 6806.2 2353.2 7172.4 4213.8 4226.0 6782.1 10053.2 2094.3 6429.7 2451.1 2427.0 1523.4 1010.8 1306.2 2169.9 4298.0 2537.3 6497.7 6998.4 8845.6 14422.9 7261.1 3353.2 7250.8 6998.4 2455.3 2166.2 931.7 1730.4 3423.2 7218.5 1946.5 1800.0 684.9 1663.5 1390.4 1345.9 1449.7 2806.6 1842.3 7149.5 6751.4 3204.5 455.9 7581.8 1168.9 3000.4 1072.0 1334.6 4239.9 1804.7 7334.0 869.7 12906.5 949.6 1457.0 16013.9 16478.6 1693.1 2194.1 12820.0 3090.7 6903.8 2852.3 3413.2 656.4 4104.3 13203.9 6755.6 505.8 788.2 1301.8 2765.6 8895.0 507.6 1740.0 3222.8 18949.7 24796.9 4133.3 5591.2 20811.1 1735.9 5272.5 2301.6 4590.4 4549.8 774.6 3284.9 1328.2 6198.4 213.0 1152.1 2402.8 1729.8 15140.6 1306.9 947.6 643.0 6763.9 1989.7 545.0 1209.9 701.5 5761.7 313.4 1239.5 5104.1 183.2 8493.4 3438.3 3353.4 1740.1 4364.3 3083.1 5690.2 13742.1 625.1 3563.9 4334.7 6017.7 64938.4 71067.8 77353.0 6560.6 102128.9 7527.7 17097.3 7247.4 7054.3 25176.6 15607.2 8656.4 7466.9 125209.0 4978.3 91398.0 10579.6 9634.4 94147.5 6806.2 7172.4 6782.1 10053.2 6497.7 6998.4 7250.8 6998.4 7218.5 7149.5 7581.8 7334.0 2757.2 1125.0 3379.9 88.5 3311.5 2793.9 6799.5 2785.4 2159.8 474.7 2597.9 3977.3 777.8 4398.0 2550.4 2021.2 177.2 941.5 2199.4 2314.2 10704.0 4251.2 290.2 504.9 1413.1 4867.0 1613.4 4331.2 60.6 6134.8 1447.8 5703.3 1715.1 617.4 2365.7 942.2 4598.0 23702.0 74983.4 533.3 113.8 2368.8 3039.4 70127.1 16939.0 1601.8 4175.9 34584.5 5085.3 129.3 22965.8 3161.9 2020.6 55.8 309.7 6905.5 5604.7 2010.8 4884.7 9790.5 21474.5 58047.8 1908.0 682.6 1341.1 1643.8 3455.6 82.1 311.2 1985.5 2226.7 1502.7 2590.4 1492.0 2816.8 13083.6 FUS "ALS6, FUS1, hnRNP-P2, HNRNPP2, TLS" ENSG00000089280 "FUS RNA binding protein" P35637 16 31180138-31191605 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "DNA-binding, RNA-binding" "Amyotrophic lateral sclerosis, Cancer-related genes, Disease variant, Neurodegeneration, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008784, CAB033036, CAB058691" Supported Supported Nucleoplasm NA NA 480000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "CAB033036: AB_2105208, CAB058691: AB_2665583, HPA008784: AB_1849181" "unprognostic (3.06e-2)" "unprognostic (2.53e-1)" "unprognostic (1.86e-2)" "unprognostic (8.68e-2)" "unprognostic (1.44e-1)" "unprognostic (8.03e-2)" "prognostic unfavorable (4.38e-4)" "unprognostic (2.15e-2)" "unprognostic (1.00e-1)" "unprognostic (5.22e-3)" "unprognostic (1.01e-1)" "unprognostic (1.01e-3)" "unprognostic (1.12e-3)" "unprognostic (1.87e-1)" "unprognostic (5.27e-1)" "unprognostic (1.66e-1)" "unprognostic (1.49e-2)" 88.6 47.6 43.6 102.9 48.6 98.9 65.1 50.6 59.2 85.3 27.2 72.5 59.5 102.0 40.9 58.5 99.2 38.8 70.4 46.9 48.6 83.6 54.3 64.8 97.9 44.3 43.0 134.2 57.3 85.0 47.2 58.3 46.9 59.1 62.8 59.4 60.0 70.4 98.6 53.8 62.6 98.1 45.7 69.3 59.4 69.1 44.8 174.1 58.6 86.0 113.2 87.5 63.2 52.1 386.6 337.2 492.6 292.9 128.3 101.7 429.3 504.1 253.1 319.6 238.3 440.7 254.9 579.6 359.3 310.7 349.4 173.0 563.6 421.0 284.3 341.5 304.7 486.6 224.6 445.3 222.7 529.7 348.5 222.4 99.8 437.5 258.9 120.1 295.7 419.6 537.6 204.7 357.0 483.0 446.2 475.5 649.0 307.7 402.0 677.0 535.9 350.1 344.0 265.6 279.1 478.9 344.5 255.7 267.8 314.9 291.8 597.5 276.3 371.5 365.5 242.1 520.5 181.4 350.4 779.0 204.4 364.2 460.9 12.3 38.2 52.8 53.6 67.3 49.9 29.1 36.5 45.9 41.7 35.2 40.3 43.9 35.0 37.3 59.3 50.3 31.0 27.4 43.6 48.6 50.6 59.2 46.9 48.6 44.3 43.0 46.9 45.7 44.8 52.1 414.6 102.5 121.2 58.1 470.7 144.8 345.7 201.0 507.6 272.6 209.8 223.8 102.1 112.9 156.3 104.8 131.3 299.3 488.8 266.8 68.4 183.6 130.8 201.0 366.1 278.4 212.1 188.2 75.4 154.8 398.5 309.0 222.8 309.7 229.7 445.0 174.2 59.1 208.5 201.9 85.9 229.5 132.2 148.4 270.7 51.2 307.3 282.7 165.4 94.6 185.4 230.8 341.9 117.6 122.2 175.7 219.4 215.5 266.6 245.4 205.4 69.7 115.4 266.3 164.3 584.4 344.2 221.0 237.1 443.6 154.3 295.1 518.2 327.9 232.6 281.2 FXN "CyaY, FA, FARR, FRDA, X25" ENSG00000165060 Frataxin Q16595 9 69035751-69079076 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Heme biosynthesis, Ion transport, Iron storage, Iron transport, Transport" Oxidoreductase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hepatocytes: 69.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022164, HPA068304" Supported Supported Mitochondria,Cytosol NA NA "Cluster 32: T-cells - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 55: Plasma cells - Humoral immune response" Mitochondria Cytosol "CAB022164: , HPA068304: AB_2685970" "unprognostic (3.38e-2)" "unprognostic (1.54e-1)" "unprognostic (7.47e-2)" "unprognostic (2.37e-3)" "unprognostic (4.08e-2)" "unprognostic (1.24e-1)" "unprognostic (1.10e-1)" "unprognostic (1.07e-1)" "unprognostic (1.07e-1)" "unprognostic (1.99e-1)" "unprognostic (4.19e-2)" "unprognostic (2.53e-1)" "unprognostic (2.71e-3)" "unprognostic (1.10e-1)" "unprognostic (9.06e-2)" "unprognostic (1.67e-1)" "unprognostic (4.74e-2)" 10.3 20.1 8.9 7.8 9.2 29.1 10.1 9.7 8.9 9.3 11.7 10.4 7.4 12.1 12.1 9.5 10.2 5.3 27.0 9.0 10.4 12.9 46.3 7.1 9.8 9.8 10.2 17.6 15.1 22.2 8.1 9.1 9.8 10.2 12.3 4.1 11.7 13.6 25.5 5.2 7.7 13.3 9.5 12.6 10.1 10.7 9.9 5.4 10.4 19.8 10.4 12.3 7.9 10.4 27.0 22.1 34.2 17.0 15.7 23.1 34.3 18.6 16.3 28.0 21.2 11.8 16.6 45.9 14.0 19.5 28.8 28.6 41.8 42.6 34.9 53.9 47.5 66.2 14.1 87.2 26.7 48.7 27.7 25.7 33.7 27.8 29.9 9.6 37.7 28.0 50.3 43.9 26.1 25.6 14.0 21.0 47.5 53.1 42.8 32.7 24.0 32.0 32.2 21.5 26.9 12.1 19.2 12.5 20.7 24.3 14.1 14.4 22.7 18.0 32.0 24.1 27.6 11.6 11.4 27.8 8.5 39.7 18.5 8.1 39.9 0.4 48.6 45.4 37.5 36.3 48.0 48.4 42.8 22.7 61.6 59.8 1.9 60.8 36.2 33.2 43.3 49.5 8.9 9.2 9.7 8.9 9.0 10.4 9.8 10.2 9.8 9.5 9.9 10.4 11.0 3.2 11.5 13.1 19.9 9.7 19.8 36.6 14.8 6.8 16.9 20.8 38.2 10.0 10.5 14.7 4.2 39.9 14.9 4.9 21.5 17.5 2.4 11.7 22.5 16.9 7.2 56.1 14.2 14.7 22.3 14.7 14.3 8.7 7.0 15.4 11.0 69.0 33.4 0.0 18.6 15.3 18.3 22.1 16.1 6.3 15.8 13.9 17.8 9.4 18.3 7.6 28.8 6.6 10.8 15.0 3.7 13.2 42.0 17.1 5.8 27.2 7.4 1.6 13.1 10.1 19.8 5.1 32.3 29.8 8.1 14.6 17.1 27.9 17.5 14.1 FYCO1 "FLJ13335, ZFYVE7" ENSG00000163820 "FYVE and coiled-coil domain autophagy adaptor 1" Q9BQS8 3 45917899-45995824 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 263.3" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 89.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035526, HPA057966" Uncertain Enhanced Vesicles NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 15: RT4 - Unknown function" "Cluster 54: Cardiomyocytes - Muscle contraction" Vesicles "HPA035526: AB_10672867, HPA057966: AB_2683567" "unprognostic (2.45e-1)" "unprognostic (6.62e-2)" "unprognostic (6.97e-3)" "unprognostic (1.14e-3)" "unprognostic (7.65e-2)" "unprognostic (1.23e-2)" "unprognostic (1.57e-2)" "unprognostic (4.53e-3)" "unprognostic (5.85e-2)" "unprognostic (8.85e-2)" "unprognostic (2.36e-1)" "unprognostic (2.98e-1)" "prognostic favorable (3.33e-11)" "unprognostic (2.90e-1)" "unprognostic (1.42e-1)" "unprognostic (2.89e-2)" "unprognostic (6.99e-2)" 16.7 13.0 10.5 9.7 12.0 6.5 13.4 9.6 9.4 23.1 11.3 42.0 8.0 25.6 10.3 21.3 15.4 18.7 66.8 8.6 10.3 10.7 10.8 14.7 8.6 15.5 10.8 23.1 12.7 20.3 7.6 8.2 14.8 19.3 10.7 33.0 14.9 22.9 263.3 19.3 14.4 28.2 15.1 10.2 20.4 3.3 11.9 10.5 16.5 104.6 8.2 39.6 16.9 15.1 10.8 10.3 3.0 13.0 27.9 21.8 4.9 10.2 23.7 13.1 14.6 5.6 9.3 7.9 5.6 14.2 12.7 7.9 8.5 17.0 15.7 3.3 9.0 11.4 8.7 6.3 19.0 8.8 7.9 24.3 16.7 21.1 20.5 20.3 26.7 13.4 7.4 11.3 9.5 6.7 9.0 5.5 4.5 8.8 9.8 3.1 8.3 4.4 15.9 37.2 2.2 3.4 6.4 20.0 17.6 4.4 9.7 5.7 20.8 5.0 5.9 17.0 5.7 6.4 4.4 2.7 17.2 11.1 9.6 0.7 0.5 0.3 2.0 0.5 2.7 0.2 1.2 2.1 0.2 0.2 0.5 0.7 0.4 1.5 0.3 1.3 1.2 0.7 10.5 12.0 9.6 9.4 8.6 10.3 15.5 10.8 14.8 15.1 11.9 15.1 9.5 28.9 13.7 12.4 4.8 4.1 4.8 5.6 3.4 11.2 8.5 4.8 89.3 8.6 13.0 16.5 35.5 4.3 8.7 6.8 3.9 8.8 0.1 6.4 8.9 9.3 9.6 6.9 0.8 8.3 2.2 14.0 12.8 11.2 2.5 14.9 11.4 9.2 4.1 0.0 0.8 7.6 2.0 5.8 4.6 1.6 12.8 5.1 10.6 10.3 4.0 20.0 6.2 8.0 21.2 11.0 2.5 17.7 3.0 17.3 8.7 6.2 18.6 37.1 6.6 20.8 12.8 2.3 0.8 8.4 4.1 2.9 12.7 6.1 6.2 7.9 FZD4 "CD344, EVR1" ENSG00000174804 "Frizzled class receptor 4" Q9ULV1 11 86945679-86955395 "CD markers, Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins" "Wnt signaling pathway" "Developmental protein, G-protein coupled receptor, Receptor, Transducer" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 120.1" "Cell type enhanced" "Detected in many" "Adipocytes: 83.0;Collecting duct cells: 36.8;Endothelial cells: 51.2;Hepatic stellate cells: 99.6;Sertoli cells: 32.9" "Cancer enhanced" "Detected in all" "renal cancer: 22.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 63.6;Hep G2: 85.2;HSkMC: 46.0;HUVEC TERT2: 93.6;TIME: 46.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042328, HPA074833" Approved Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Plasma membrane" Nucleoplasm "HPA042328: AB_10962494, HPA074833: AB_2686716" "unprognostic (6.49e-2)" "unprognostic (1.49e-2)" "unprognostic (1.03e-1)" "unprognostic (1.03e-1)" "unprognostic (5.87e-2)" "unprognostic (5.51e-2)" "unprognostic (1.82e-1)" "unprognostic (6.97e-2)" "unprognostic (3.33e-2)" "unprognostic (3.79e-2)" "unprognostic (1.36e-2)" "unprognostic (2.22e-1)" "prognostic favorable (8.60e-5)" "unprognostic (1.05e-2)" "unprognostic (9.96e-2)" "unprognostic (9.22e-2)" "unprognostic (1.97e-1)" 120.1 9.5 6.7 5.8 6.2 0.3 55.6 5.1 7.3 12.5 7.8 14.9 2.8 12.2 7.6 6.5 16.3 11.5 27.4 5.6 5.9 27.1 14.6 32.9 6.2 6.5 6.3 12.9 9.5 6.4 8.7 11.7 7.0 12.5 6.3 1.1 12.2 30.2 31.5 5.9 8.8 13.4 5.6 14.1 14.1 5.1 8.5 3.9 18.1 40.6 4.6 10.5 9.5 5.9 1.3 1.1 2.7 5.2 63.6 16.5 3.7 8.4 7.6 3.2 3.3 7.1 0.9 0.0 1.8 2.6 4.4 2.8 3.1 1.3 2.5 0.2 2.1 2.8 2.3 85.2 18.9 0.0 0.1 46.0 0.5 2.8 0.5 7.5 93.6 0.1 3.9 0.4 2.2 2.2 0.0 0.0 3.9 7.5 18.8 0.1 4.8 0.2 9.0 13.7 0.6 0.8 3.5 1.0 1.4 5.6 12.0 0.0 46.3 7.8 5.1 9.2 1.7 0.4 1.3 0.0 1.0 0.1 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 6.7 6.2 5.1 7.3 5.6 5.9 6.5 6.3 7.0 5.6 8.5 5.9 83.0 0.0 1.3 9.8 0.5 1.5 0.5 1.3 2.2 0.7 5.5 3.2 8.3 7.2 2.0 36.8 10.4 0.2 0.5 1.0 3.9 0.5 0.7 0.4 2.7 51.2 0.0 2.7 8.1 1.6 0.2 17.7 4.1 0.5 0.0 9.1 99.6 14.1 0.2 0.0 3.4 1.3 0.0 6.7 1.8 2.2 9.3 0.6 0.0 10.3 0.0 0.2 2.1 3.0 0.7 1.0 0.1 6.8 0.3 1.4 0.7 9.4 2.1 0.2 32.9 14.4 26.6 0.3 3.2 1.3 0.6 0.3 0.4 16.6 1.1 0.2 GAB1 DFNB26 ENSG00000109458 "GRB2 associated binding protein 1" Q13480 4 143336762-143474568 "Disease related genes, Human disease related genes, Predicted intracellular proteins, RAS pathway related proteins" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 114.8" "Cell type enhanced" "Detected in many" "Excitatory neurons: 162.7;Microglial cells: 192.0;Oligodendrocyte precursor cells: 288.0;Oligodendrocytes: 1013.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "NK-cell: 5.0" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "REH: 74.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034333, HPA066404" Approved Approved "Nucleoli fibrillar center,Plasma membrane,Cytosol" NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 14: REH - Unknown function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Nucleoli fibrillar center, Plasma membrane" Cytosol "CAB034333: AB_2107855, HPA066404: " "unprognostic (1.14e-1)" "unprognostic (1.16e-1)" "unprognostic (1.32e-3)" "unprognostic (1.66e-1)" "unprognostic (4.71e-2)" "unprognostic (1.79e-2)" "unprognostic (4.17e-2)" "unprognostic (1.23e-1)" "unprognostic (1.35e-2)" "unprognostic (8.20e-2)" "unprognostic (2.10e-1)" "unprognostic (2.20e-1)" "prognostic favorable (3.91e-5)" "unprognostic (4.99e-2)" "unprognostic (2.70e-1)" "unprognostic (1.68e-1)" "unprognostic (1.91e-1)" 7.9 8.6 23.3 6.7 69.9 11.5 9.9 35.5 30.0 10.6 2.5 19.7 12.1 18.1 14.2 20.4 9.2 12.5 30.5 20.4 34.6 13.9 9.1 17.9 6.1 57.3 45.4 19.5 8.1 11.3 4.3 21.0 47.9 8.5 22.8 6.9 8.9 14.7 13.4 10.7 12.3 17.7 26.4 7.5 11.3 9.2 45.7 5.4 7.5 16.5 8.7 7.1 9.7 114.8 6.7 1.4 16.7 12.1 8.3 7.9 22.0 4.6 15.2 5.4 9.4 12.8 11.2 0.2 1.4 6.5 3.7 3.8 16.2 5.3 6.2 1.0 3.9 12.2 3.7 6.1 5.7 1.6 2.3 9.7 9.5 6.6 4.3 11.5 7.2 0.2 4.1 21.7 3.8 9.7 0.9 0.0 4.8 3.5 5.3 74.6 8.2 8.8 8.4 8.0 3.9 11.8 3.1 13.3 5.6 11.2 8.5 1.6 5.5 6.9 5.4 3.4 3.5 34.6 18.2 26.3 4.7 4.8 5.7 4.1 0.4 0.5 0.0 0.5 0.2 0.9 0.0 0.0 0.5 1.8 0.0 0.0 2.6 5.0 1.7 2.2 0.0 0.3 23.3 69.9 35.5 30.0 20.4 34.6 57.3 45.4 47.9 26.4 45.7 114.8 13.4 28.9 19.0 89.5 13.1 20.3 8.8 3.3 12.0 2.1 11.6 8.9 34.0 8.6 5.3 12.9 0.0 23.5 10.9 26.2 0.0 6.6 0.9 8.8 9.3 16.3 22.2 40.8 162.7 2.6 10.6 14.4 11.2 21.6 2.5 9.6 13.9 7.0 6.1 3.3 62.2 27.8 4.1 11.6 10.2 3.8 20.8 8.8 16.0 192.0 5.6 15.4 1.0 288.0 1013.6 4.9 10.7 18.8 94.4 7.2 9.3 5.4 3.4 0.8 13.1 7.0 14.3 2.0 5.3 19.9 24.9 10.4 2.7 4.4 13.6 13.5 GABBR2 "GABABR2, GPR51, GPRC3B, HG20" ENSG00000136928 "Gamma-aminobutyric acid type B receptor subunit 2" O75899 9 98288109-98708935 "Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "G-protein coupled receptor, Receptor, Transducer" "Disease variant, Epilepsy, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 11 "brain: 90.4" "Group enriched" "Detected in some" 4 "Excitatory neurons: 386.5;Inhibitory neurons: 395.1" "Group enriched" "Detected in many" 10 "glioma: 7.2;thyroid cancer: 11.6;urothelial cancer: 3.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ: 14.6;fHDF/TERT166: 7.3;HUVEC TERT2: 29.5;U-138 MG: 11.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA013820, HPA031684, CAB079065" Enhanced Approved NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB079065: , HPA013820: AB_1849364, HPA031684: AB_2673993" "unprognostic (2.00e-1)" "unprognostic (7.56e-2)" "unprognostic (3.75e-1)" "unprognostic (3.09e-5)" "unprognostic (2.52e-1)" "unprognostic (1.16e-1)" "unprognostic (2.81e-2)" "unprognostic (1.42e-1)" "unprognostic (2.66e-1)" "unprognostic (4.43e-2)" "unprognostic (1.43e-2)" "unprognostic (2.06e-1)" "unprognostic (1.76e-2)" "unprognostic (3.52e-2)" "unprognostic (1.91e-1)" "unprognostic (2.68e-2)" "unprognostic (3.45e-2)" 0.0 3.6 26.0 0.2 40.8 0.0 0.0 10.6 90.4 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.6 39.9 18.0 0.0 0.0 0.3 0.0 12.7 19.6 0.0 0.1 0.2 0.6 0.1 12.5 0.0 0.0 8.5 0.0 0.1 2.8 0.2 0.0 0.1 8.3 0.0 0.2 0.6 39.5 0.0 1.4 0.5 0.2 0.5 0.0 36.3 0.0 0.0 0.0 0.0 0.1 0.1 1.2 14.6 2.9 3.0 5.5 0.1 0.1 0.0 0.9 7.3 0.6 0.0 0.1 0.2 1.0 0.0 0.5 0.0 0.0 0.0 1.3 0.0 0.0 0.4 0.0 0.9 0.2 0.0 29.5 0.0 0.3 0.1 0.0 0.4 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.1 0.8 4.0 0.0 0.1 3.5 0.0 0.0 0.0 0.1 1.2 11.5 0.7 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.3 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.1 0.0 26.0 40.8 10.6 90.4 39.9 18.0 12.7 19.6 12.5 8.3 39.5 36.3 0.1 0.0 0.0 14.0 0.0 0.1 0.0 0.0 0.0 86.4 0.5 0.1 1.9 0.0 0.1 0.0 0.0 0.5 0.0 0.1 0.0 0.0 90.3 0.1 0.0 0.6 0.0 0.0 386.5 0.2 1.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 395.1 0.0 0.0 0.0 0.0 34.5 0.3 0.1 1.8 11.2 0.0 1.8 0.0 26.2 7.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 7.4 0.0 0.3 1.3 0.7 0.9 0.0 0.1 0.4 0.0 0.3 0.1 0.0 GABRA1 EJM5 ENSG00000022355 "Gamma-aminobutyric acid type A receptor subunit alpha1" P14867 5 161847063-161899981 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Chloride channel, Ion channel, Ligand-gated ion channel, Receptor" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 30 "brain: 55.1;retina: 17.8" "Group enriched" "Detected in some" 11 "Bipolar cells: 198.0;Excitatory neurons: 220.5;Inhibitory neurons: 215.2" "Cancer enriched" "Detected in single" 5 "glioma: 1.1" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022502, HPA029363, HPA055746" Enhanced Supported Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 6: Brain - Smell perception" "Cluster 56: Bipolar cells - Visual perception" "Plasma membrane" Nucleoplasm "CAB022502: , HPA029363: , HPA055746: AB_2682904" "unprognostic (2.58e-2)" "unprognostic (4.78e-3)" "unprognostic (1.84e-1)" "unprognostic (3.31e-1)" "unprognostic (2.43e-1)" 0.0 1.2 6.7 0.0 11.1 0.0 0.0 24.8 55.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 7.7 21.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 17.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.1 14.3 0.6 0.0 0.0 0.2 0.0 0.0 24.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.7 11.1 24.8 55.1 7.7 21.7 0.0 0.0 0.0 0.0 14.3 24.0 0.0 0.0 0.0 17.6 0.0 0.0 0.0 0.0 0.0 198.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.8 0.0 0.0 0.1 0.0 0.0 220.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.4 215.2 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 17.8 0.0 3.5 0.0 8.0 16.4 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 9.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GABRA2 ENSG00000151834 "Gamma-aminobutyric acid type A receptor subunit alpha2" P47869 4 46243548-46475230 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Chloride channel, Ion channel, Ligand-gated ion channel, Receptor" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 31.5;epididymis: 8.8" "Group enriched" "Detected in many" 5 "Astrocytes: 425.4;Excitatory neurons: 156.2;Inhibitory neurons: 111.6" "Cancer enhanced" "Detected in some" "colorectal cancer: 0.6;glioma: 0.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "U-2 OS: 4.2;U-87 MG: 2.1;WM-115: 2.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029363, CAB079061" Supported Uncertain "Nucleoplasm,Plasma membrane" "Intracellular and membrane" NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 9: U-2 OS - Unknown function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" Nucleoplasm "CAB079061: , HPA029363: " "unprognostic (2.03e-2)" "unprognostic (2.77e-1)" "unprognostic (2.45e-4)" "unprognostic (6.87e-3)" "unprognostic (2.65e-1)" "unprognostic (2.08e-1)" "unprognostic (1.01e-1)" "unprognostic (4.09e-1)" "unprognostic (6.90e-3)" "unprognostic (8.83e-2)" "unprognostic (2.22e-5)" "unprognostic (1.75e-1)" "unprognostic (1.15e-1)" "unprognostic (2.67e-1)" "unprognostic (3.04e-2)" 1.2 0.3 20.2 0.4 29.9 0.2 1.3 2.6 31.5 0.5 0.0 3.0 0.9 0.4 8.8 0.7 0.0 0.5 0.2 29.4 16.0 6.3 0.4 0.1 0.3 0.3 1.9 0.7 0.1 0.0 0.5 0.4 0.0 0.1 2.1 2.4 0.2 0.7 0.1 0.2 6.0 0.2 1.3 1.2 0.5 0.5 13.8 0.4 0.1 0.1 0.4 0.2 0.7 8.8 0.1 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.1 0.3 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.1 0.0 0.1 0.4 0.6 0.0 0.0 0.3 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.2 4.2 0.2 0.0 0.2 0.6 0.0 2.1 0.1 2.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 20.2 29.9 2.6 31.5 29.4 16.0 0.3 1.9 0.0 1.3 13.8 8.8 4.9 0.0 0.0 425.4 0.0 0.1 0.0 0.0 1.2 15.3 0.2 0.0 0.6 0.0 0.0 40.5 4.2 0.0 0.0 23.1 3.9 0.0 9.1 1.2 31.7 1.0 31.8 0.0 156.2 0.0 0.0 0.5 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 111.6 3.4 0.0 0.0 0.0 17.1 0.6 0.1 1.8 16.9 0.0 0.2 0.0 13.0 5.5 0.0 4.7 0.0 0.0 0.0 38.1 0.1 0.0 1.1 0.0 0.0 0.2 0.0 1.3 0.0 0.1 0.0 0.1 0.0 2.7 0.0 GABRA5 ENSG00000186297 "Gamma-aminobutyric acid type A receptor subunit alpha5" P31644 15 26866911-26949208 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Ion transport, Transport" "Chloride channel, Ion channel, Ligand-gated ion channel, Receptor" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 12 "brain: 111.0" "Group enriched" "Detected in some" 4 "Excitatory neurons: 27.6;Inhibitory neurons: 14.1" "Cancer enhanced" "Detected in some" "glioma: 0.8" "Group enriched" "Detected in many" 4 "amygdala: 52.0;basal ganglia: 73.5;cerebral cortex: 98.6;hippocampal formation: 111.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 10 "A549: 35.3;HAP1: 12.0;NTERA-2: 16.2;U-2 OS: 13.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA029363, HPA077031, CAB079022" Supported Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 5: NTERA-2 - Transcription" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" Nucleoplasm "CAB079022: , HPA029363: , HPA077031: AB_2686825" "unprognostic (6.33e-2)" "unprognostic (8.94e-3)" "unprognostic (1.04e-1)" "unprognostic (2.50e-1)" "unprognostic (1.81e-1)" "unprognostic (3.75e-1)" "unprognostic (9.50e-3)" "unprognostic (2.57e-1)" "unprognostic (7.63e-2)" "unprognostic (8.50e-2)" "unprognostic (1.44e-2)" 0.0 0.0 52.0 0.1 73.5 0.0 0.0 0.0 98.6 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.7 0.5 111.0 7.2 0.1 0.1 0.0 0.0 0.0 3.0 0.0 0.1 0.7 0.5 0.0 0.0 0.2 0.0 1.6 0.0 0.1 0.0 0.0 0.1 0.6 0.0 0.0 1.2 0.7 12.0 9.0 0.1 0.1 0.3 0.0 0.0 19.6 0.0 35.3 0.5 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.8 0.0 0.0 12.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 16.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.5 0.0 0.1 0.2 1.8 0.0 0.0 0.0 0.0 13.4 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 52.0 73.5 0.0 98.6 111.0 7.2 0.0 3.0 0.0 0.0 12.0 19.6 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 27.6 0.0 0.0 0.0 0.0 0.0 0.0 4.6 0.0 0.0 0.1 0.0 14.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.0 0.0 0.8 0.0 1.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.1 0.0 2.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 GABRB1 ENSG00000163288 "Gamma-aminobutyric acid type A receptor subunit beta1" P18505 4 46993723-47426447 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Ion transport, Transport" "Chloride channel, Ion channel, Ligand-gated ion channel, Receptor" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "brain: 26.3" "Group enriched" "Detected in some" 15 "Astrocytes: 926.2;Excitatory neurons: 440.3;Inhibitory neurons: 507.4;Oligodendrocyte precursor cells: 266.9" "Cancer enhanced" "Detected in single" "glioma: 0.7" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "REH: 7.1;U-87 MG: 2.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 65: Brain - Ion transport" "Cluster 14: REH - Unknown function" "Cluster 64: Astrocytes - Nervous system maintenance" "unprognostic (3.11e-2)" "unprognostic (7.56e-3)" "unprognostic (5.10e-2)" "unprognostic (1.83e-1)" "unprognostic (1.11e-1)" "unprognostic (4.98e-3)" "unprognostic (8.16e-3)" "unprognostic (6.22e-2)" "unprognostic (2.72e-2)" "unprognostic (2.34e-1)" 0.0 0.2 19.1 0.0 24.8 0.0 0.0 0.3 26.3 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.1 0.2 3.6 26.2 24.6 0.3 0.0 0.0 0.0 0.5 7.4 0.0 0.0 0.3 1.5 0.1 0.6 0.0 0.1 2.4 0.1 0.0 0.0 0.0 0.1 0.0 1.1 0.0 0.0 0.0 26.1 0.0 0.1 0.0 0.0 0.0 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.1 24.8 0.3 26.3 26.2 24.6 0.5 7.4 0.6 1.1 26.1 2.3 0.0 0.0 0.0 926.2 0.0 0.0 0.0 0.0 0.0 0.8 0.1 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.3 0.1 1.2 0.0 440.3 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 507.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 33.7 0.1 32.9 0.0 266.9 16.3 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 1.3 0.0 0.0 0.1 0.3 1.9 0.0 0.0 0.1 0.0 0.0 0.3 0.0 GABRB2 ENSG00000145864 "Gamma-aminobutyric acid type A receptor subunit beta2" P47870 5 161288429-161549044 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Chloride channel, Ion channel, Ligand-gated ion channel, Receptor" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 11 "brain: 71.7" "Group enriched" "Detected in many" 20 "Excitatory neurons: 570.3;Inhibitory neurons: 780.2" "Cancer enriched" "Detected in some" 20 "thyroid cancer: 10.2" "Group enriched" "Detected in many" 7 "cerebellum: 63.2;cerebral cortex: 71.7" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 10 "SCLC-21H: 22.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001964, HPA067632" Enhanced NA NA "Cluster 6: Brain - Smell perception" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB001964: , HPA067632: AB_2685874" "unprognostic (5.46e-2)" "unprognostic (1.03e-1)" "unprognostic (3.29e-1)" "unprognostic (2.26e-6)" "unprognostic (2.33e-2)" "unprognostic (6.65e-2)" "unprognostic (3.58e-2)" "unprognostic (1.82e-1)" "unprognostic (1.01e-2)" "unprognostic (1.22e-1)" "unprognostic (5.19e-3)" "unprognostic (2.24e-4)" "unprognostic (1.22e-1)" "unprognostic (1.33e-2)" "unprognostic (1.58e-1)" "unprognostic (7.18e-3)" "unprognostic (1.04e-2)" 0.7 2.3 0.6 0.0 5.8 0.0 0.1 63.2 71.7 0.5 0.0 0.6 1.2 0.1 3.4 0.0 0.4 0.0 0.1 9.2 10.0 1.8 0.0 0.9 0.0 0.0 0.0 0.1 0.1 0.1 0.5 0.2 0.0 0.1 1.1 6.5 0.5 0.6 0.1 0.1 0.6 0.1 0.0 2.4 0.5 0.6 7.9 0.1 0.5 0.4 0.0 0.0 0.0 9.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.6 0.0 0.0 0.0 1.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 22.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 2.2 0.1 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 5.8 63.2 71.7 9.2 10.0 0.0 0.0 0.0 0.0 7.9 9.5 0.0 0.0 0.0 21.5 0.0 0.3 0.0 0.1 0.0 19.8 0.1 0.0 1.9 0.0 0.0 0.0 27.1 0.0 0.0 1.0 5.9 0.0 1.6 0.0 0.3 0.3 1.2 0.0 570.3 0.0 0.0 2.6 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 780.2 1.8 4.1 0.0 0.4 1.4 0.0 1.3 0.0 20.6 0.0 2.3 0.0 33.7 17.9 0.0 0.5 0.4 0.0 0.1 0.0 3.2 0.0 10.6 0.0 0.3 3.5 3.1 1.8 0.1 0.4 0.0 0.0 1.9 4.2 0.1 GABRB3 ENSG00000166206 "Gamma-aminobutyric acid type A receptor subunit beta3" P28472 15 26543546-26939539 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Chloride channel, Ion channel, Ligand-gated ion channel, Receptor" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 29.5;retina: 31.9" "Cell type enhanced" "Detected in many" "Bipolar cells: 152.4;Excitatory neurons: 519.6;Inhibitory neurons: 258.7;Oligodendrocyte precursor cells: 139.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 68.5;HAP1: 27.9;NTERA-2: 48.3;OE19: 21.6;SCLC-21H: 44.2;U-2 OS: 18.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 58: Brain - Synaptic function" "Cluster 5: NTERA-2 - Transcription" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "unprognostic (1.72e-1)" "unprognostic (4.91e-2)" "unprognostic (3.20e-2)" "unprognostic (4.25e-2)" "unprognostic (1.66e-1)" "unprognostic (7.07e-2)" "unprognostic (1.00e-1)" "unprognostic (8.87e-2)" "unprognostic (1.02e-1)" "unprognostic (2.44e-1)" "unprognostic (1.44e-2)" "unprognostic (3.62e-1)" "unprognostic (3.56e-3)" "unprognostic (2.99e-2)" "unprognostic (1.49e-1)" "unprognostic (3.33e-2)" "unprognostic (4.05e-1)" 0.6 5.5 16.6 0.5 24.3 0.0 0.8 3.9 29.5 2.3 0.0 1.2 0.8 1.7 1.0 1.2 2.3 13.6 6.2 28.0 18.0 7.3 0.9 0.9 0.1 0.0 1.3 1.9 4.8 2.1 15.7 0.0 0.3 5.0 0.9 31.9 0.5 1.2 0.1 0.7 0.6 1.4 3.1 0.6 5.7 4.0 11.6 1.5 8.7 0.1 0.2 1.1 0.5 13.8 0.0 68.5 10.7 0.0 0.0 0.0 2.6 1.1 0.0 0.0 0.0 0.1 0.0 0.9 0.0 0.1 0.0 0.0 27.9 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.1 0.0 5.4 3.3 0.0 0.0 0.0 0.0 0.0 14.8 2.1 0.1 0.0 0.0 4.8 0.0 48.3 21.6 3.4 0.0 0.0 0.0 4.7 0.0 44.2 16.6 0.0 0.1 0.0 5.0 0.1 0.0 0.0 0.0 18.1 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 16.6 24.3 3.9 29.5 28.0 18.0 0.0 1.3 0.3 3.1 11.6 13.8 0.4 12.8 3.6 33.3 0.0 0.0 0.8 0.7 1.2 152.4 1.0 0.8 15.3 24.3 1.7 5.5 39.6 0.4 0.0 1.4 0.0 4.6 10.7 1.4 4.0 1.2 10.3 0.0 519.6 0.4 0.0 1.7 2.6 0.6 0.0 1.1 0.7 0.4 0.0 75.7 258.7 1.9 0.0 0.6 0.0 5.6 1.8 0.0 0.0 5.6 0.2 7.9 0.0 139.7 8.7 1.7 0.4 3.4 0.0 3.3 0.2 7.0 13.5 53.7 0.0 1.0 0.9 8.6 29.3 0.7 0.1 0.3 0.1 0.5 0.9 0.4 GABRD ENSG00000187730 "Gamma-aminobutyric acid type A receptor subunit delta" O14764 1 2019329-2030758 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Ion transport, Transport" "Chloride channel, Ion channel" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 14 "brain: 49.6" "Cell type enhanced" "Detected in some" "Bipolar cells: 14.7;Excitatory neurons: 30.0;Horizontal cells: 13.5;Inhibitory neurons: 37.4;Spermatogonia: 11.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "EFO-21: 1.4;HMC-1: 1.2;MCF7: 4.4;NB-4: 2.7;SH-SY5Y: 1.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044371 Enhanced Uncertain "Golgi apparatus,Vesicles" NA NA "Cluster 6: Brain - Smell perception" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Golgi apparatus, Vesicles" "HPA044371: AB_2678916" "unprognostic (4.28e-2)" "unprognostic (1.90e-1)" "unprognostic (5.95e-8)" "unprognostic (6.34e-3)" "unprognostic (2.66e-3)" "unprognostic (1.04e-2)" "unprognostic (3.44e-3)" "unprognostic (2.14e-1)" "unprognostic (4.53e-2)" "unprognostic (1.12e-1)" "unprognostic (3.77e-2)" "unprognostic (1.99e-1)" "prognostic unfavorable (4.12e-8)" "unprognostic (1.72e-1)" "unprognostic (1.76e-1)" "unprognostic (2.77e-1)" "unprognostic (5.16e-2)" 0.3 1.5 12.8 0.0 16.9 0.0 0.5 49.6 40.5 0.1 0.1 0.2 0.0 0.3 0.1 0.3 0.2 0.4 0.7 14.7 5.4 0.7 0.2 0.9 0.2 14.3 18.1 0.2 0.1 0.7 2.7 0.1 20.2 0.2 0.0 1.4 0.3 0.0 0.3 0.4 0.2 0.3 1.0 0.3 0.1 3.6 29.7 0.1 0.9 0.4 0.0 0.2 0.2 14.7 0.0 0.3 0.0 0.9 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.4 0.0 0.1 0.0 0.7 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.4 0.0 2.7 1.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.6 0.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 12.8 16.9 49.6 40.5 14.7 5.4 14.3 18.1 20.2 1.0 29.7 14.7 1.0 3.2 3.6 4.9 0.1 0.5 0.0 0.0 0.0 14.7 0.3 0.0 0.9 0.0 6.2 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.2 0.2 0.2 3.4 0.0 0.0 30.0 0.0 0.3 0.5 0.0 0.2 2.5 0.3 0.0 0.0 0.1 13.5 37.4 0.0 0.0 0.0 0.3 0.2 0.0 0.9 0.0 8.4 0.0 1.4 0.0 3.0 4.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 4.4 1.6 0.0 0.0 4.8 0.1 11.3 0.1 0.0 0.3 0.4 0.2 0.1 0.1 GABRG2 ENSG00000113327 "Gamma-aminobutyric acid type A receptor subunit gamma2" P18507 5 162000057-162162977 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Chloride channel, Ion channel" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 20.0;retina: 10.9" "Group enriched" "Detected in some" 7 "Bipolar cells: 119.0;Excitatory neurons: 239.9;Inhibitory neurons: 167.8" "Cancer enhanced" "Detected in single" "glioma: 1.4" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "basophil: 4.5" "Group enriched" "Detected in many" 5 "B-cells: 1.6;granulocytes: 4.5;T-cells: 1.5" "Cell line enhanced" "Detected in many" "CACO-2: 10.3;Karpas-707: 10.2;RPMI-8226: 13.4;SuSa: 13.0;U-266/70: 20.1;U-266/84: 18.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB079060 Supported NA NA "Cluster 6: Non-specific - Transcription" "Cluster 58: Brain - Synaptic function" "Cluster 16: U-266 - Nucleosome" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "CAB079060: " "unprognostic (2.88e-2)" "unprognostic (1.56e-2)" "unprognostic (6.31e-3)" "unprognostic (3.07e-3)" "unprognostic (1.52e-1)" 0.3 4.7 7.9 0.4 9.0 2.2 0.1 7.2 20.0 0.0 0.0 0.7 1.2 0.3 0.4 0.4 0.5 2.6 0.8 9.6 10.6 0.2 0.4 0.9 0.4 4.7 4.6 0.7 0.1 0.0 1.1 1.9 10.7 0.1 0.5 10.9 0.5 0.1 0.5 2.2 0.9 0.8 0.5 0.4 1.9 0.7 9.3 1.7 0.5 0.5 0.5 0.2 0.0 7.5 3.9 1.7 2.3 0.2 0.0 0.1 1.9 0.7 0.0 0.0 0.0 10.3 5.5 0.5 5.9 0.0 0.2 1.1 1.6 0.0 0.0 1.0 1.0 0.0 1.7 1.2 0.0 0.0 0.6 0.4 0.3 0.0 0.0 0.1 0.0 1.0 2.4 10.2 0.0 2.8 0.5 0.1 7.4 3.1 3.6 0.5 0.1 13.4 0.0 3.1 1.1 0.9 0.3 0.5 4.1 13.0 6.7 6.9 0.1 0.3 5.2 0.4 0.5 20.1 18.7 0.1 0.1 0.5 0.3 4.5 0.1 0.3 0.2 0.1 1.2 1.6 0.3 0.3 0.0 1.4 1.5 0.3 0.7 0.4 0.1 0.3 0.4 0.1 7.9 9.0 7.2 20.0 9.6 10.6 4.7 4.6 10.7 0.5 9.3 7.5 0.0 19.2 23.5 15.3 0.0 0.0 0.0 0.0 0.0 119.0 0.1 0.0 0.4 0.0 10.5 0.0 12.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 239.9 0.0 0.1 1.4 0.0 0.0 8.8 0.0 0.0 0.0 0.1 16.8 167.8 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 12.2 0.0 2.6 0.0 12.1 15.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 6.6 9.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.6 0.0 0.0 0.0 GAD1 GAD ENSG00000128683 "Glutamate decarboxylase 1" Q99259 2 170813213-170861151 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Neurotransmitter biosynthesis" "Decarboxylase, Lyase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 12 "brain: 98.5;parathyroid gland: 46.3;retina: 29.7" "Group enriched" "Detected in many" 8 "Inhibitory neurons: 392.8;Oligodendrocyte precursor cells: 146.8" "Cancer enhanced" "Detected in many" "endometrial cancer: 4.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HaCaT: 20.1;HEL: 64.5" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "olfactory bulb: 547.6" "CAB004415, HPA048871, HPA058412, CAB078176" Enhanced Supported Approved "Vesicles,Plasma membrane,Cytosol" NA NA "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 36: HEL - Hemostasis" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Vesicles, Plasma membrane, Cytosol" "CAB004415: AB_627650, CAB078176: AB_2665792, HPA048871: , HPA058412: AB_2683710" "unprognostic (1.28e-1)" "prognostic favorable (7.31e-4)" "unprognostic (1.87e-2)" "prognostic favorable (8.61e-4)" "unprognostic (1.12e-1)" "unprognostic (3.05e-1)" "unprognostic (4.97e-7)" "unprognostic (1.51e-1)" "unprognostic (7.72e-2)" "unprognostic (4.27e-4)" "unprognostic (6.75e-2)" "unprognostic (9.18e-3)" "unprognostic (6.90e-5)" "unprognostic (2.93e-2)" "unprognostic (6.57e-2)" "unprognostic (1.56e-2)" "unprognostic (3.08e-3)" 0.2 3.0 22.1 0.0 29.9 3.3 0.1 15.5 33.0 1.0 0.0 0.0 0.0 1.6 4.3 0.4 0.2 0.1 0.0 17.1 98.5 4.8 0.1 0.2 0.1 12.4 41.6 0.2 0.2 46.3 5.0 0.4 17.6 0.8 0.1 29.7 0.1 0.3 0.0 0.2 0.1 0.0 12.7 0.1 0.0 3.2 31.1 0.8 0.1 0.0 0.2 0.6 0.4 14.2 18.2 0.7 0.0 7.3 0.0 0.0 0.1 0.4 0.0 2.6 1.7 4.6 6.7 0.0 0.9 0.5 2.9 20.1 2.3 0.6 1.6 2.8 13.4 64.5 6.0 0.2 0.0 0.3 1.1 0.0 5.5 0.0 2.3 0.6 0.1 0.5 17.0 0.3 0.8 1.5 0.0 0.0 8.1 9.7 6.7 1.0 4.6 0.4 8.5 9.4 6.7 2.1 12.6 0.0 3.5 0.6 0.2 0.0 0.0 12.0 1.7 2.4 7.0 0.0 0.0 0.1 11.5 3.2 16.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 22.1 29.9 15.5 33.0 17.1 98.5 12.4 41.6 17.6 12.7 31.1 14.2 0.0 0.0 0.0 14.7 0.0 0.3 2.1 7.7 2.2 32.5 0.1 0.1 1.3 0.0 3.6 0.0 10.4 0.0 0.0 0.2 7.9 4.5 5.6 4.4 0.4 0.4 3.0 5.5 2.6 5.6 0.1 0.2 0.0 2.9 0.0 5.5 0.0 0.0 4.0 5.0 392.8 0.3 2.0 0.8 0.4 6.2 0.6 0.5 0.0 7.5 0.0 4.9 0.0 146.8 7.6 2.9 0.0 0.0 0.1 0.9 0.0 0.0 4.7 6.0 0.0 0.0 1.2 4.4 7.7 0.6 0.1 0.5 0.0 0.1 0.1 0.4 GAL "GAL-GMAP, GALN, GLNN, GMAP" ENSG00000069482 "Galanin and GMAP prepropeptide" P22466 11 68683779-68691175 "Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Hormone, Neuropeptide" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 23 "brain: 645.9;pituitary gland: 885.8" "Group enriched" "Detected in many" 4 "Basal prostatic cells: 22.2;Ductal cells: 38.9;Endometrial ciliated cells: 64.2;Endometrial stromal cells: 50.8;Exocrine glandular cells: 52.1;Extravillous trophoblasts: 48.7;Glandular and luminal cells: 26.4;Pancreatic endocrine cells: 39.5;Prostatic glandular cells: 82.5;Urothelial cells: 24.3" "Cancer enhanced" "Detected in many" "testis cancer: 22.2" "Region enriched" "Detected in many" 13 "hypothalamus: 645.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CACO-2: 267.2;HEK 293: 119.3;K-562: 139.5;NB-4: 493.5;SH-SY5Y: 189.6" "Region enhanced" "Detected in many" "hypothalamus: 82.6" "Low region specificity" "Detected in all" "HPA049864, CAB079779" Enhanced Supported Supported "Golgi apparatus,Vesicles" "Secreted to blood" NA NA 60000 200000 "Cluster 7: Monocytes - Unknown function" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 24: NB-4 - Immune response" "Cluster 36: Stromal cells - Cell proliferation" "Golgi apparatus" Vesicles "CAB079779: , HPA049864: AB_2680922" "unprognostic (8.56e-2)" "unprognostic (1.45e-2)" "unprognostic (7.50e-2)" "prognostic unfavorable (1.22e-4)" "unprognostic (2.70e-1)" "unprognostic (2.27e-2)" "unprognostic (8.07e-3)" "prognostic unfavorable (8.17e-4)" "unprognostic (5.98e-2)" "unprognostic (1.07e-2)" "unprognostic (8.84e-2)" "unprognostic (7.42e-2)" "unprognostic (1.20e-1)" "unprognostic (8.85e-2)" "unprognostic (7.88e-2)" "unprognostic (5.38e-2)" "unprognostic (3.24e-2)" 3.2 0.9 2.8 14.9 2.1 0.7 4.4 1.1 5.2 1.0 0.8 17.6 1.8 0.2 0.0 0.8 1.0 0.2 1.0 2.2 645.9 1.5 0.3 0.5 0.1 48.5 5.1 0.2 2.1 0.1 885.8 0.3 13.8 4.4 4.0 0.0 0.9 0.2 0.4 33.3 4.1 9.9 0.6 0.3 9.7 1.0 19.5 0.7 0.4 0.0 0.0 0.7 2.9 2.6 0.0 11.0 1.1 0.3 0.0 0.0 24.0 36.7 0.0 0.7 0.0 267.2 9.9 0.0 12.7 1.3 0.4 0.1 0.0 0.2 0.0 0.0 119.3 6.4 74.6 0.0 1.3 3.7 0.0 1.7 4.0 0.0 0.1 0.0 6.3 0.0 139.5 0.0 0.2 77.2 0.0 493.5 60.3 2.9 23.7 0.0 0.1 51.1 0.6 0.0 49.8 189.6 25.8 1.5 0.0 26.8 1.5 57.6 0.0 0.0 0.0 0.3 2.9 0.0 0.0 0.1 0.0 0.4 0.5 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 2.1 1.1 5.2 2.2 645.9 48.5 5.1 13.8 0.6 19.5 2.6 0.6 0.0 0.0 0.0 0.2 2.0 22.2 0.1 0.0 0.0 3.2 5.8 1.4 0.0 0.0 0.0 0.0 0.6 0.1 0.7 0.0 38.9 0.1 64.2 50.8 3.4 1.8 4.2 2.1 52.1 48.7 6.6 2.0 26.4 4.5 0.4 0.0 0.0 2.0 0.0 0.2 1.1 4.1 0.0 1.2 0.2 0.0 0.7 1.8 0.0 0.6 0.0 0.0 0.0 0.3 39.5 0.1 0.0 1.0 82.5 0.0 0.4 0.0 0.0 0.0 1.6 6.7 2.2 10.9 1.1 3.4 1.9 0.8 0.0 1.3 24.3 GAN "GAN1, GIG, KLHL16" ENSG00000261609 Gigaxonin Q9H2C0 16 81314944-81390809 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skin 1: 24.8" "Cell type enhanced" "Detected in many" "Suprabasal keratinocytes: 130.4;Urothelial cells: 188.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 10.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011825, HPA049473" Approved Supported Microtubules NA NA "Cluster 15: NK-cells - Transcription" "Cluster 27: Brain & Skin - Unknown function" "Cluster 28: BEWO - Transcription regulation" "Cluster 22: Epithelial cell types - Mixed function" Microtubules "CAB011825: AB_732515, HPA049473: AB_2680782" "unprognostic (1.78e-1)" "unprognostic (1.55e-1)" "unprognostic (8.23e-2)" "unprognostic (2.51e-2)" "unprognostic (8.37e-2)" "unprognostic (1.43e-1)" "unprognostic (2.42e-4)" "unprognostic (1.90e-1)" "unprognostic (3.86e-1)" "unprognostic (1.20e-1)" "unprognostic (1.22e-3)" "unprognostic (5.91e-3)" "unprognostic (3.12e-3)" "unprognostic (5.93e-2)" "unprognostic (9.98e-2)" "unprognostic (1.46e-2)" "unprognostic (5.86e-2)" 1.3 0.9 7.3 0.7 5.7 0.7 2.4 6.6 4.7 2.6 1.0 2.3 0.8 1.3 1.1 5.4 1.3 0.6 1.5 6.9 8.8 1.0 1.1 1.7 0.7 9.3 8.6 1.4 1.2 0.8 1.4 0.8 5.5 2.0 1.2 3.2 2.3 0.7 1.5 24.8 1.4 0.9 8.7 0.9 1.8 0.9 8.7 0.9 1.1 1.4 1.3 1.5 4.3 9.2 1.6 2.0 1.5 2.1 1.9 1.0 10.4 1.2 0.7 0.8 0.3 5.1 1.8 2.5 1.4 1.6 0.4 3.1 2.7 1.3 1.8 0.6 1.4 2.2 1.8 4.1 2.0 2.1 2.4 1.1 3.8 1.3 3.5 1.1 1.7 2.1 2.8 1.1 1.1 9.1 1.9 2.9 4.0 2.2 0.6 3.7 1.4 1.0 1.6 5.0 1.5 1.0 4.3 4.2 1.4 3.6 2.9 2.0 2.5 2.3 2.1 0.8 1.9 2.2 2.7 5.8 1.2 2.4 1.7 0.7 0.4 0.2 0.8 0.4 0.7 0.4 0.8 0.6 0.2 0.5 0.7 0.9 0.3 0.9 0.3 0.9 0.6 0.2 7.3 5.7 6.6 4.7 6.9 8.8 9.3 8.6 5.5 8.7 8.7 9.2 12.2 12.8 8.2 69.5 9.9 91.3 66.8 15.0 34.1 28.4 15.4 18.5 12.5 7.2 29.5 5.5 89.6 19.3 17.4 27.5 0.0 9.4 2.3 11.6 19.3 14.7 5.4 12.6 21.2 6.7 15.4 14.1 17.3 14.0 1.3 7.2 12.1 6.7 5.6 23.5 29.5 15.1 10.2 6.8 30.9 4.6 9.6 8.6 37.4 14.0 7.5 14.0 9.2 22.1 18.3 18.6 16.8 12.8 11.0 75.0 14.8 3.8 30.1 43.8 6.6 20.2 17.6 11.9 16.4 67.1 130.4 21.3 16.1 5.3 15.6 188.7 GARS1 "CMT2D, DSMAV, GARS, GlyRS, SMAD1" ENSG00000106105 "Glycyl-tRNA synthetase 1" P41250 7 30580533-30634033 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Protein biosynthesis" "Aminoacyl-tRNA synthetase, Hydrolase, Ligase, Transferase" "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 34.1;Cytotrophoblasts: 47.0;Extravillous trophoblasts: 70.0;Hofbauer cells: 44.3;Syncytiotrophoblasts: 39.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017896, HPA019097" Enhanced Supported Cytosol "Intracellular and membrane" NA NA 560000 "Cluster 44: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 30: Epithelial cell lines - Translation" "Cluster 24: Non-specific - Transcription regulation" Cytosol "HPA017896: AB_1849478, HPA019097: AB_1849480" "prognostic unfavorable (1.02e-4)" "unprognostic (2.46e-2)" "unprognostic (5.45e-2)" "prognostic unfavorable (8.48e-4)" "unprognostic (2.04e-1)" "unprognostic (1.57e-3)" "prognostic unfavorable (8.95e-5)" "unprognostic (7.31e-3)" "unprognostic (4.76e-1)" "unprognostic (4.00e-3)" "unprognostic (1.77e-1)" "unprognostic (4.45e-2)" "prognostic unfavorable (1.70e-5)" "unprognostic (3.92e-1)" "unprognostic (3.40e-2)" "unprognostic (6.32e-2)" "prognostic unfavorable (3.04e-5)" 34.2 31.0 33.3 43.3 36.5 32.0 31.7 34.2 46.2 32.6 49.9 39.8 27.6 29.1 37.3 53.8 23.3 29.9 32.9 38.6 45.7 42.7 46.0 34.0 47.2 38.1 34.7 26.7 78.5 58.1 36.5 39.9 42.0 26.8 48.6 46.9 36.1 29.3 48.1 43.4 26.0 49.8 33.2 22.3 47.4 51.5 43.4 40.7 51.5 45.0 67.3 54.0 29.4 35.2 231.4 119.8 103.4 364.5 191.9 286.8 172.0 332.4 330.5 184.0 369.8 159.5 115.4 375.9 96.2 443.1 281.6 174.5 262.6 230.2 327.7 92.9 82.5 182.6 84.8 141.1 604.0 267.6 149.8 272.5 391.9 265.8 304.9 128.1 241.6 354.1 350.2 465.4 296.7 154.7 216.8 204.3 259.6 222.4 183.4 114.0 90.1 299.0 219.5 109.1 117.9 177.4 88.1 261.5 509.2 182.8 225.3 409.3 208.2 82.2 262.9 164.9 217.9 403.8 390.8 445.9 289.4 398.8 392.9 40.0 27.0 24.1 22.9 35.8 27.4 21.0 26.0 28.8 35.8 16.3 25.2 30.2 5.2 20.9 41.7 18.5 31.9 23.9 33.3 36.5 34.2 46.2 38.6 45.7 38.1 34.7 42.0 33.2 43.4 35.2 10.7 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 34.1 0.0 0.0 0.0 0.0 47.0 10.2 0.0 0.0 0.0 0.0 0.0 0.0 3.9 0.0 0.0 0.0 0.0 70.0 13.6 0.0 0.0 0.0 0.0 0.0 0.0 44.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 39.8 2.0 0.0 0.0 0.0 GBA "GBA1, GLUC" ENSG00000177628 "Glucosylceramidase beta" P04062 1 155234452-155244699 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cholesterol metabolism, Lipid metabolism, Sphingolipid metabolism, Steroid metabolism, Sterol metabolism" "Glycosidase, Glycosyltransferase, Hydrolase, Transferase" "Disease variant, Gaucher disease, Ichthyosis, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hofbauer cells: 65.2;Syncytiotrophoblasts: 59.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006667, CAB037171, CAB037289" Supported "Intracellular and membrane" NA NA 470000 "Cluster 14: Monocytes - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 10: Non-specific - Unknown function" "CAB037171: AB_1078958, CAB037289: AB_1078957, HPA006667: AB_1078979" "unprognostic (6.03e-2)" "unprognostic (6.02e-2)" "unprognostic (3.41e-1)" "unprognostic (2.42e-1)" "unprognostic (6.00e-3)" "unprognostic (2.97e-1)" "unprognostic (1.04e-3)" "unprognostic (4.76e-2)" "unprognostic (1.22e-1)" "unprognostic (6.02e-2)" "unprognostic (1.73e-1)" "unprognostic (1.33e-1)" "unprognostic (1.47e-1)" "unprognostic (1.76e-1)" "unprognostic (3.04e-2)" "unprognostic (3.15e-1)" "unprognostic (2.94e-2)" 23.9 37.9 22.5 24.8 24.4 41.7 25.1 25.9 24.3 26.7 27.4 35.1 23.9 22.9 50.2 27.6 20.5 28.3 19.1 26.1 27.7 33.6 33.7 28.3 19.9 27.3 28.0 16.9 33.4 103.1 43.8 39.2 36.2 23.3 39.8 12.4 26.8 33.6 9.1 33.4 22.5 29.7 25.0 29.0 22.7 8.8 29.2 19.7 37.7 13.6 28.0 27.1 21.9 29.5 38.0 72.2 25.1 34.2 254.8 55.8 29.3 65.4 230.4 95.3 119.0 43.2 135.7 26.3 70.4 153.7 152.0 76.2 35.9 46.4 50.3 55.5 25.1 21.8 45.1 23.2 73.6 25.8 87.0 73.4 38.2 199.7 30.2 100.2 85.6 22.2 23.4 42.9 113.5 82.6 32.5 11.9 16.3 61.9 51.2 26.8 41.9 108.1 63.9 29.0 23.9 33.5 57.4 136.4 145.3 45.6 102.6 63.3 65.7 71.7 31.7 91.9 53.7 86.2 78.6 20.4 126.6 23.4 56.4 21.4 36.0 15.3 20.8 35.8 13.2 11.1 15.7 13.8 22.4 7.8 11.0 11.7 28.9 11.6 37.2 12.5 23.4 23.3 22.5 24.4 25.9 24.3 26.1 27.7 27.3 28.0 36.2 25.0 29.2 29.5 6.8 3.2 5.1 3.3 8.8 6.0 5.8 9.5 4.6 4.0 12.7 6.5 8.8 17.2 8.1 12.9 2.1 30.7 6.2 36.1 3.9 30.5 1.4 12.3 9.7 12.2 14.6 7.4 3.4 32.4 27.9 18.6 20.9 17.9 7.0 7.9 17.2 23.2 65.2 5.0 2.7 11.6 4.1 33.3 9.9 2.8 9.9 26.8 26.6 1.0 22.8 11.7 12.3 0.5 3.3 29.5 15.8 9.1 19.8 6.7 28.6 20.6 8.5 6.0 0.0 9.4 21.6 22.5 12.5 8.6 4.4 59.4 8.5 6.0 10.4 6.5 GBA2 "AD035, DKFZp762K054, KIAA1605, SPG46" ENSG00000070610 "Glucosylceramidase beta 2" Q9HCG7 9 35736866-35749228 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cholesterol metabolism, Lipid metabolism, Sphingolipid metabolism, Steroid metabolism, Sterol metabolism" "Glycosidase, Glycosyltransferase, Hydrolase, Transferase" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 114.7;Rod photoreceptor cells: 102.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024026 Approved Approved "Nucleoplasm,Golgi apparatus,Cytosol" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 20: HeLa - Mitochondria" "Cluster 9: Photoreceptor cells - Phototransduction" "Nucleoplasm, Golgi apparatus" Cytosol "HPA024026: AB_1849530" "unprognostic (3.34e-2)" "unprognostic (2.90e-1)" "unprognostic (2.99e-1)" "unprognostic (1.06e-2)" "unprognostic (1.41e-1)" "unprognostic (5.83e-3)" "unprognostic (2.20e-2)" "unprognostic (2.09e-2)" "unprognostic (3.99e-2)" "unprognostic (8.69e-2)" "prognostic favorable (6.00e-4)" "unprognostic (9.01e-3)" "prognostic favorable (1.24e-11)" "unprognostic (7.62e-3)" "unprognostic (2.94e-1)" "unprognostic (7.69e-2)" "prognostic favorable (6.60e-4)" 39.3 45.7 48.5 23.2 47.5 16.3 39.9 52.8 53.7 46.4 63.3 83.5 54.2 44.6 26.9 36.3 44.2 26.3 83.3 47.2 54.2 84.4 65.9 54.1 24.6 54.1 56.2 39.8 54.1 37.2 65.5 24.7 56.1 60.2 41.0 71.1 50.0 27.7 75.8 39.3 89.7 22.9 45.1 58.5 63.9 30.8 58.9 18.3 61.7 43.7 21.6 53.0 40.9 48.7 18.1 29.3 39.6 38.4 18.8 11.4 40.0 24.1 18.8 23.9 25.0 32.8 14.1 19.3 17.1 14.7 51.5 18.4 38.2 16.2 12.0 27.5 26.2 20.8 87.8 35.6 20.8 31.2 49.4 19.8 29.8 20.3 21.1 57.9 63.4 18.9 20.7 36.0 22.6 18.0 8.5 32.0 41.2 36.6 45.7 15.5 16.0 16.3 33.3 41.9 32.2 43.0 13.5 33.3 24.5 48.1 22.8 27.8 44.6 25.8 30.9 22.4 29.9 24.2 16.5 16.0 32.3 11.3 20.5 11.1 2.9 2.0 3.8 3.9 2.5 3.7 3.7 4.7 2.8 4.7 2.2 1.9 3.2 2.4 2.5 4.4 2.8 2.2 48.5 47.5 52.8 53.7 47.2 54.2 54.1 56.2 56.1 45.1 58.9 48.7 12.7 12.8 8.0 45.1 11.2 7.4 18.2 9.4 6.2 77.5 15.0 10.8 13.7 17.2 14.5 27.6 114.7 11.1 16.6 71.7 21.5 10.5 14.1 10.0 8.1 16.0 35.8 17.2 23.5 12.0 10.2 8.0 46.4 13.8 14.0 18.7 30.7 20.1 9.2 52.2 26.4 35.8 16.2 12.8 10.7 24.3 12.5 10.7 12.4 8.4 13.3 16.2 12.3 18.1 20.2 15.1 57.6 9.8 11.7 15.8 87.4 17.8 17.9 102.9 13.1 12.2 12.2 9.2 5.7 8.8 9.9 22.2 9.4 11.3 41.4 26.3 GCH1 "DYT14, DYT5, DYT5a, GCH, GTPCH1" ENSG00000131979 "GTP cyclohydrolase 1" P30793 14 54842008-54902826 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Tetrahydrobiopterin biosynthesis" "Allosteric enzyme, Hydrolase" "Disease variant, Dystonia, Parkinsonism, Phenylketonuria" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 31.4;liver: 36.7" "Cell type enhanced" "Detected in many" "Enteroendocrine cells: 212.5;Hepatocytes: 94.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "non-classical monocyte: 11.1" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "BEWO: 23.5;Daudi: 25.0;JURKAT: 23.0;SH-SY5Y: 50.9" "Low region specificity" "Detected in many" "Region enhanced" "Detected in many" "midbrain: 12.7" HPA028612 Approved Supported "Nucleoplasm,Nuclear membrane,Cytosol" No No "Cluster 51: Monocytes - Innate immune response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 41: Macrophages - Immune response" Nucleoplasm "Nuclear membrane, Cytosol" "HPA028612: AB_10602135" "unprognostic (3.77e-2)" "unprognostic (2.67e-3)" "unprognostic (6.73e-2)" "unprognostic (2.39e-1)" "unprognostic (9.26e-2)" "unprognostic (1.27e-1)" "unprognostic (7.26e-2)" "unprognostic (1.75e-1)" "unprognostic (3.97e-1)" "prognostic favorable (8.69e-4)" "prognostic favorable (1.41e-4)" "unprognostic (1.23e-1)" "unprognostic (1.96e-2)" "unprognostic (7.22e-3)" "unprognostic (1.76e-2)" "unprognostic (2.23e-1)" "prognostic favorable (6.67e-4)" 2.4 6.0 2.1 8.1 3.0 31.4 1.8 1.1 2.0 0.4 1.5 2.4 9.4 0.4 0.2 3.5 1.2 0.4 1.9 1.9 4.8 4.6 36.7 4.1 7.0 3.5 16.1 0.5 2.6 0.9 1.8 0.3 8.4 1.5 2.4 0.1 1.7 1.0 0.4 2.2 7.5 1.1 2.4 6.9 2.8 1.2 7.8 3.8 0.8 0.2 2.0 3.3 1.4 2.0 4.7 0.6 1.3 7.1 0.0 0.0 23.5 0.0 2.0 2.4 2.9 1.4 1.0 25.0 6.9 0.2 5.8 4.0 4.9 1.5 0.1 10.9 5.2 0.6 0.3 3.1 8.4 0.0 1.9 0.3 0.7 1.2 0.1 0.0 0.7 23.0 2.8 0.0 0.0 5.0 15.1 0.3 0.4 6.5 8.2 9.6 2.8 0.0 2.9 1.6 11.6 50.9 3.3 2.4 1.6 0.4 2.9 1.5 0.3 0.1 4.0 9.9 3.8 10.5 8.4 7.8 3.1 8.4 0.0 0.0 2.6 0.2 2.8 5.3 2.1 0.7 1.0 1.5 2.8 1.9 2.5 1.3 0.3 1.8 11.1 0.1 2.1 1.2 2.1 3.0 1.1 2.0 1.9 4.8 3.5 16.1 8.4 2.4 7.8 2.0 19.2 3.2 4.8 0.7 33.4 74.6 30.9 23.6 17.6 0.0 19.4 13.2 6.5 4.3 13.6 5.5 2.1 1.9 50.9 21.8 7.9 8.7 0.5 16.8 5.8 19.8 212.5 10.1 3.8 9.4 44.3 15.3 43.8 29.3 0.0 0.3 6.8 94.6 6.1 0.0 5.9 22.7 4.1 28.0 33.3 0.6 0.3 55.8 10.6 15.9 29.5 0.7 29.9 0.5 0.8 11.0 13.6 4.9 14.4 20.5 17.1 48.6 6.9 0.4 0.0 12.5 7.5 2.2 6.7 20.8 76.1 4.2 41.8 11.9 12.2 39.0 GCNT2 "bA360O19.2, bA421M1.1, CCAT, GCNT5, IGNT, II, NACGT1, NAGCT1, ULG3" ENSG00000111846 "Glucosaminyl (N-acetyl) transferase 2 (I blood group)" Q8N0V5 6 10492223-10629368 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "prostate: 13.5" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 76.9;Endometrial ciliated cells: 79.1;Glandular and luminal cells: 105.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "basophil: 1.9" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "EFO-21: 44.2;Hep G2: 19.7;SK-MEL-30: 17.1;SuSa: 21.4" "Region enriched" "Detected in all" 4 "basal ganglia: 61.1" "Low region specificity" "Detected in all" HPA026776 Approved Approved "Golgi apparatus" No No 750000 "Cluster 41: Basophils - Cellular respiration" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 38: EFO-21 - Unknown function" "Cluster 44: Endometrium - Transcription" "Golgi apparatus" "HPA026776: AB_1849573" "unprognostic (2.47e-1)" "unprognostic (6.87e-3)" "unprognostic (3.12e-1)" "unprognostic (1.42e-2)" "unprognostic (9.31e-2)" "unprognostic (2.51e-1)" "unprognostic (4.11e-2)" "unprognostic (2.39e-1)" "unprognostic (1.27e-1)" "unprognostic (2.11e-2)" "unprognostic (6.28e-4)" "unprognostic (3.96e-2)" "unprognostic (1.58e-3)" "unprognostic (6.54e-2)" "unprognostic (6.32e-2)" "unprognostic (1.13e-1)" "unprognostic (1.53e-1)" 0.6 0.3 0.7 1.0 0.6 0.3 10.1 2.5 1.1 4.2 4.5 3.6 5.2 1.4 0.2 1.4 0.8 1.5 6.6 0.8 1.1 5.7 5.1 3.9 1.8 1.2 1.0 0.3 1.3 0.4 1.4 2.6 1.4 13.5 2.0 0.3 4.2 0.3 0.7 1.4 5.8 1.6 0.9 1.5 5.9 2.5 0.9 0.5 1.2 1.8 2.4 1.0 0.7 1.0 6.3 4.9 1.5 4.8 0.0 0.0 9.6 0.0 4.1 1.1 0.5 11.0 5.2 3.5 44.2 0.0 3.2 0.3 0.4 5.1 2.9 3.1 1.8 0.5 2.6 19.7 0.0 1.7 4.7 0.0 0.0 0.5 0.0 2.4 9.1 0.0 0.4 0.0 0.4 0.0 0.0 4.0 4.4 0.0 3.6 0.2 3.8 6.0 16.0 2.9 4.0 1.2 0.0 14.4 17.1 21.4 0.3 0.8 6.4 0.8 0.5 0.0 5.0 0.1 0.0 2.4 0.8 0.3 2.3 1.9 1.1 0.5 0.1 0.8 0.0 0.7 0.1 0.1 0.8 0.4 0.1 0.2 0.1 0.2 0.2 0.2 0.0 0.3 0.7 0.6 2.5 1.1 0.8 1.1 1.2 1.0 1.4 0.9 0.9 1.0 1.4 76.9 32.4 1.0 9.5 4.6 6.6 15.5 9.6 5.1 30.5 16.1 18.4 2.8 28.6 7.3 0.0 27.9 6.4 15.5 11.7 2.9 4.3 79.1 5.5 11.0 2.4 25.9 0.7 24.7 2.1 2.0 16.8 105.5 2.5 0.0 12.8 32.0 15.8 3.3 11.8 5.6 6.1 7.7 9.4 8.2 0.3 7.8 49.8 52.5 11.1 2.4 0.0 18.6 1.1 12.0 11.9 0.0 1.0 16.6 44.3 13.4 27.9 0.6 0.0 0.7 2.2 6.2 27.6 11.2 1.7 10.9 3.1 0.0 16.3 8.1 GDAP1 "CMT2K, CMT4, CMT4A" ENSG00000104381 "Ganglioside induced differentiation associated protein 1" Q8TB36 8 74320613-74518007 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 26.0" "Cell type enhanced" "Detected in many" "Bipolar cells: 46.9;Cone photoreceptor cells: 47.9;Excitatory neurons: 75.7;Horizontal cells: 47.1;Inhibitory neurons: 67.3;Oligodendrocyte precursor cells: 67.8;Rod photoreceptor cells: 47.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "SH-SY5Y: 38.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014266, HPA024334" Enhanced Supported Mitochondria,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 58: Brain - Synaptic function" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 56: Bipolar cells - Visual perception" Mitochondria Cytosol "HPA014266: AB_1849581, HPA024334: AB_1849583" "unprognostic (3.19e-2)" "unprognostic (1.52e-3)" "unprognostic (2.72e-1)" "prognostic unfavorable (1.82e-4)" "unprognostic (3.31e-1)" "unprognostic (4.36e-2)" "unprognostic (1.72e-2)" "prognostic favorable (2.68e-4)" "unprognostic (3.88e-1)" "unprognostic (4.17e-1)" "unprognostic (9.44e-3)" "unprognostic (2.44e-1)" "unprognostic (5.40e-2)" "unprognostic (3.29e-1)" "unprognostic (6.99e-2)" "prognostic unfavorable (4.54e-4)" "unprognostic (2.73e-1)" 2.7 9.6 19.0 3.3 22.5 1.2 4.0 15.2 26.0 2.9 4.9 2.5 2.4 3.9 1.9 4.0 2.8 2.5 2.1 25.3 19.7 4.2 1.5 2.4 3.3 14.5 17.0 6.0 7.4 12.4 20.6 1.2 18.1 4.1 2.4 19.0 2.4 4.1 2.7 1.7 2.3 2.8 12.2 1.9 2.0 4.7 16.7 4.5 6.6 3.1 2.8 3.9 2.6 20.5 3.5 16.8 17.7 4.8 1.2 1.6 1.5 1.8 8.2 8.3 9.5 7.8 5.0 14.8 2.5 1.2 10.6 6.6 12.4 7.0 16.2 19.7 3.6 7.4 8.9 14.0 0.7 7.6 15.8 4.7 2.3 5.3 8.2 0.9 1.1 7.3 3.4 0.3 4.8 5.7 12.6 0.4 20.1 24.5 17.9 8.7 9.2 3.2 2.9 15.3 18.2 38.9 13.1 3.4 9.7 4.9 14.9 2.6 0.0 11.7 6.2 2.9 5.5 9.3 15.7 6.8 7.3 0.3 13.8 0.5 0.9 1.0 0.8 3.1 1.0 1.4 0.8 1.3 0.8 1.3 0.6 0.6 1.8 0.7 5.5 0.2 4.0 0.8 19.0 22.5 15.2 26.0 25.3 19.7 14.5 17.0 18.1 12.2 16.7 20.5 6.4 6.4 5.1 27.1 5.9 1.8 7.4 4.2 6.2 46.9 6.2 6.1 5.9 5.7 3.6 3.7 47.9 0.4 3.9 2.1 9.8 5.2 5.4 15.4 7.0 6.7 20.4 2.1 75.7 5.8 0.3 4.8 3.1 2.8 17.2 2.1 6.4 1.8 4.7 47.1 67.3 1.7 12.2 6.3 2.5 1.3 4.1 4.6 1.8 15.0 2.9 23.5 4.1 67.8 41.9 3.7 1.4 5.7 2.6 2.6 3.6 6.6 4.9 47.7 0.0 8.0 5.5 14.7 13.1 3.7 1.3 0.0 3.1 6.5 1.7 3.8 GDAP2 "dJ776P7.1, FLJ20142, MACROD3" ENSG00000196505 "Ganglioside induced differentiation associated protein 2" Q9NXN4 1 117863485-117929621 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046185 Approved Approved "Endoplasmic reticulum" Yes No "Cluster 45: Eosinophils - Innate immune response" "Cluster 34: Non-specific - Transcription" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 59: Non-specific - Transcription" "Endoplasmic reticulum" "HPA046185: AB_10960897" "unprognostic (4.12e-2)" "unprognostic (1.40e-1)" "unprognostic (2.64e-1)" "unprognostic (1.82e-2)" "unprognostic (4.33e-2)" "unprognostic (1.05e-1)" "unprognostic (1.53e-3)" "unprognostic (1.25e-1)" "unprognostic (2.60e-1)" "unprognostic (4.26e-3)" "unprognostic (2.26e-3)" "unprognostic (6.38e-2)" "unprognostic (1.18e-1)" "unprognostic (4.09e-2)" "unprognostic (3.28e-2)" "unprognostic (8.68e-2)" "unprognostic (1.68e-1)" 3.0 2.4 2.3 3.2 2.1 8.0 3.2 3.6 2.7 3.4 3.4 3.8 4.0 2.8 4.0 3.1 2.4 3.2 2.5 2.0 2.3 4.8 5.1 3.4 3.6 2.1 2.6 2.4 4.5 4.9 2.3 4.1 2.4 3.4 4.4 2.9 3.0 3.3 1.8 2.9 4.7 3.0 2.4 4.2 4.4 4.8 2.7 4.1 4.6 2.1 4.4 4.5 3.1 2.9 9.2 5.1 6.1 5.1 6.5 3.1 9.0 5.2 6.8 10.3 9.9 5.4 6.2 3.6 6.2 7.1 7.8 5.3 8.1 6.8 12.6 7.2 4.7 5.4 6.7 5.9 7.7 6.8 6.6 2.5 8.5 12.9 9.9 4.7 6.9 8.1 5.7 7.6 8.6 9.6 6.0 5.5 10.6 6.9 8.8 3.2 16.7 5.3 5.8 9.1 4.6 5.1 6.3 10.7 8.2 18.3 3.7 6.8 4.3 7.3 8.5 8.5 7.1 7.9 6.1 5.1 9.4 4.8 9.1 11.4 6.7 12.6 2.4 7.2 3.8 2.3 2.7 2.9 6.5 2.2 2.4 2.3 6.5 4.1 7.6 1.5 3.6 3.2 2.3 2.1 3.6 2.7 2.0 2.3 2.1 2.6 2.4 2.4 2.7 2.9 9.2 9.6 8.6 27.7 13.5 13.5 6.5 8.1 8.6 13.1 8.1 5.5 7.8 8.6 10.8 3.7 18.8 12.4 11.6 13.4 7.9 10.6 21.2 12.8 9.0 7.6 4.2 13.9 36.7 6.2 11.4 7.7 18.3 11.5 0.0 10.4 6.4 9.0 13.8 15.2 39.1 14.0 14.2 17.2 15.8 5.7 5.9 20.0 10.6 34.7 16.2 9.2 8.2 31.7 35.8 10.7 7.5 7.2 21.0 9.8 17.8 10.2 10.5 13.7 0.0 8.6 10.2 28.4 14.5 14.3 13.8 21.1 13.8 6.7 8.3 9.6 GDF6 "BMP13, KFS, KFS1, SGM1" ENSG00000156466 "Growth differentiation factor 6" Q6KF10 8 96142333-96160806 "Disease related genes, Human disease related genes, Predicted secreted proteins" Apoptosis "Cytokine, Developmental protein, Growth factor" "Disease variant, Dwarfism, Leber congenital amaurosis, Microphthalmia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "placenta: 10.9" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 2.3;Distal tubular cells: 1.9;Excitatory neurons: 1.6;Fibroblasts: 3.1;Oligodendrocyte precursor cells: 7.1;Spermatogonia: 2.4" "Cancer enhanced" "Detected in some" "renal cancer: 2.8;thyroid cancer: 2.3" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "hTERT-RPE1: 20.4;LHCN-M2: 33.1;SuSa: 15.9" "Not detected" "Not detected" "Region enriched" "Detected in single" 5 "midbrain: 1.2" HPA045206 Uncertain Supported "Nucleoplasm,Nuclear membrane,Vesicles" "Secreted to blood" NA NA "Cluster 28: Placenta - Pregnancy" "Cluster 12: NES - Nervous system development" "Cluster 33: Fibroblasts - ECM organization" Vesicles "Nucleoplasm, Nuclear membrane" "HPA045206: AB_10962508" "unprognostic (1.13e-1)" "unprognostic (1.60e-1)" "unprognostic (1.83e-2)" "unprognostic (9.66e-9)" "unprognostic (6.49e-2)" "unprognostic (1.47e-1)" "unprognostic (1.41e-1)" "unprognostic (3.18e-2)" "unprognostic (3.80e-3)" "unprognostic (1.09e-3)" "unprognostic (5.37e-2)" "unprognostic (8.13e-3)" "prognostic unfavorable (2.17e-4)" "unprognostic (5.88e-4)" "unprognostic (1.88e-2)" "unprognostic (2.68e-2)" "unprognostic (1.71e-1)" 1.3 0.1 0.3 0.9 0.3 0.0 0.4 0.4 0.8 0.2 0.0 0.7 0.3 1.4 0.4 0.4 0.5 2.4 2.8 0.3 0.4 0.2 0.4 0.2 0.1 0.8 0.4 0.1 0.7 0.1 0.1 10.9 1.0 0.3 0.3 0.0 0.0 1.4 0.0 0.0 0.9 1.1 0.4 0.0 0.6 0.6 0.8 0.1 0.6 0.0 0.0 0.8 0.9 0.4 0.0 0.0 0.2 0.0 1.1 0.6 3.9 2.6 0.0 2.3 2.0 0.0 0.0 0.0 0.0 0.2 0.0 1.4 0.0 0.0 3.2 0.0 0.6 0.0 0.0 0.0 3.0 0.0 0.0 0.1 0.0 3.0 0.0 20.4 0.2 0.0 0.0 0.0 33.1 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.9 0.0 0.0 0.0 0.8 0.0 0.3 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.3 0.4 0.8 0.3 0.4 0.8 0.4 1.0 0.4 0.8 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.1 2.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.6 0.8 0.1 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.8 1.0 2.4 0.0 0.0 0.3 0.1 0.0 0.0 0.1 GDNF "ATF1, ATF2, HFB1-GDNF" ENSG00000168621 "Glial cell derived neurotrophic factor" P39905 5 37812677-37840041 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" "Growth factor" "Cancer-related genes, Disease variant, Hirschsprung disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 8.2;skeletal muscle: 10.1" "Cell type enhanced" "Detected in some" "Fibroblasts: 3.3;Skeletal myocytes: 11.5;Spermatogonia: 3.4;Theca cells: 2.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "hTEC/SVTERT24-B: 41.4;SuSa: 12.6;U-87 MG: 12.6;WM-115: 46.5" "Region enhanced" "Detected in single" "basal ganglia: 2.8" "Low region specificity" "Detected in some" "CAB005210, HPA070283" Supported Approved Nucleoplasm,Vesicles "Secreted in other tissues" NA NA "Cluster 80: Striated muscle - Unknown function" "Cluster 17: WM-115 - Nervous system development" "Cluster 37: Myocytes - Muscle contraction" Vesicles Nucleoplasm "CAB005210: AB_2247684, HPA070283: AB_2686246" "unprognostic (1.08e-1)" "unprognostic (6.30e-2)" "unprognostic (3.54e-2)" "unprognostic (8.87e-2)" "unprognostic (1.09e-1)" "unprognostic (1.08e-1)" "unprognostic (5.33e-2)" "unprognostic (1.92e-1)" "unprognostic (3.71e-2)" "unprognostic (2.01e-2)" "unprognostic (2.41e-1)" "unprognostic (2.10e-1)" "unprognostic (1.16e-4)" "unprognostic (2.04e-1)" "unprognostic (8.86e-2)" "unprognostic (1.05e-1)" "unprognostic (4.42e-2)" 0.1 0.4 2.3 1.6 1.5 0.1 0.3 5.8 1.4 0.8 0.0 8.2 1.4 1.3 2.5 0.9 0.9 0.9 0.8 0.6 1.6 0.9 0.7 0.0 0.1 0.7 3.1 3.6 0.0 0.0 0.1 5.0 1.0 1.3 2.4 0.3 0.2 4.5 10.1 1.3 2.0 2.1 0.2 0.4 1.6 0.4 6.1 0.1 0.1 4.3 0.0 0.7 0.8 2.9 0.0 0.0 0.1 0.1 1.8 1.0 0.0 5.5 3.4 1.1 1.6 0.0 0.1 0.1 0.0 7.4 0.1 0.2 0.0 0.1 2.2 0.0 0.2 0.0 0.4 0.5 0.2 0.1 0.1 1.8 0.1 41.4 0.0 1.4 0.0 0.0 0.0 0.0 2.4 0.2 0.0 0.1 0.4 0.1 0.0 0.1 9.0 0.0 0.0 0.2 0.5 0.0 0.3 0.2 2.7 12.6 0.1 0.0 0.0 5.5 0.0 1.4 6.2 4.0 0.0 0.0 12.6 0.0 46.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.3 1.5 5.8 1.4 0.6 1.6 0.7 3.1 1.0 0.2 6.1 2.9 0.0 0.0 0.0 0.0 0.0 0.9 0.0 1.0 0.6 0.6 0.0 0.3 0.7 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.2 0.0 0.0 0.2 0.0 0.1 3.3 0.0 0.0 0.0 0.1 0.4 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.1 0.0 1.5 0.6 0.0 0.0 0.4 0.0 0.2 0.0 0.7 0.1 0.0 0.0 11.5 1.8 0.9 3.4 0.0 0.3 0.1 0.0 2.6 0.0 0.5 GFAP FLJ45472 ENSG00000131095 "Glial fibrillary acidic protein" P14136 17 44903159-44916937 "Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Disease variant, Leukodystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "brain: 13076.3" "Cell type enriched" "Detected in some" 7 "Astrocytes: 381.9" "Cancer enriched" "Detected in some" 368 "glioma: 2468.0" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 6.2" "Group enriched" "Detected in many" 5 "granulocytes: 6.2;NK-cells: 1.7" "Cell line enhanced" "Detected in many" "U-87 MG: 6.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000039, HPA056030, HPA063513" Enhanced Supported Supported "Intermediate filaments" No No 170000000 "Cluster 33: Neutrophils - Chromatin organization" "Cluster 70: Brain - Nervous system development" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 64: Astrocytes - Nervous system maintenance" "Intermediate filaments" "CAB000039: AB_10013382, HPA056030: AB_2683015, HPA063513: AB_2685027" "unprognostic (1.79e-2)" "unprognostic (2.74e-1)" "unprognostic (9.83e-2)" "unprognostic (2.12e-5)" "unprognostic (4.08e-1)" "unprognostic (5.09e-1)" "unprognostic (1.26e-1)" "unprognostic (6.53e-2)" "unprognostic (6.57e-3)" "unprognostic (7.35e-2)" "unprognostic (5.86e-2)" "unprognostic (1.24e-1)" "unprognostic (7.63e-2)" "unprognostic (2.75e-5)" "unprognostic (1.49e-1)" "unprognostic (1.66e-1)" "unprognostic (1.64e-1)" 1.9 1.8 5096.2 2.2 5407.4 14.1 3.5 5902.8 4887.4 1.9 2342.2 1.4 0.4 0.9 1.5 3.7 2.2 1.6 8.2 5059.3 9869.7 2.1 1.7 1.3 1.9 13076.3 9001.4 2.1 1.5 1.6 33.9 0.7 9204.1 1.3 1.0 117.7 1.9 1.0 2.1 2.6 0.7 0.9 10040.2 1.5 1.5 1.4 8068.5 0.4 1.7 0.3 1.1 1.4 0.9 10496.9 1.0 0.7 1.2 2.3 0.0 0.4 0.2 1.0 1.2 1.5 1.2 1.3 1.5 2.2 1.9 0.5 0.9 2.7 1.4 0.4 1.8 3.0 1.1 1.4 2.1 0.9 0.0 0.2 2.2 0.1 0.8 1.0 0.0 1.7 0.0 2.3 0.7 5.3 0.8 1.3 1.9 2.6 1.6 0.1 3.3 0.7 0.7 1.2 0.7 0.6 1.6 1.8 0.1 1.7 0.2 1.0 1.2 1.2 0.7 1.2 0.9 1.1 2.0 0.7 1.6 1.6 6.1 2.0 2.7 1.5 0.8 0.3 0.3 0.6 0.2 0.2 0.2 0.4 0.1 0.5 0.3 0.4 6.2 1.7 0.5 0.5 0.2 0.2 5096.2 5407.4 5902.8 4887.4 5059.3 9869.7 13076.3 9001.4 9204.1 10040.2 8068.5 10496.9 0.0 0.0 0.0 381.9 0.1 0.0 0.1 0.0 0.0 0.8 1.3 0.6 5.2 0.0 0.0 0.0 6.2 0.0 0.1 0.0 0.0 0.3 0.1 0.1 0.1 0.8 0.0 0.0 0.5 0.2 0.0 0.3 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 3.7 0.0 53.5 0.0 10.1 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 4.4 0.0 0.2 0.1 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.1 GFPT1 "GFA, GFAT, GFAT1, GFPT" ENSG00000198380 "Glutamine--fructose-6-phosphate transaminase 1" Q06210 2 69319780-69387250 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Biological rhythms" "Aminotransferase, Transferase" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 184.2;Intestinal goblet cells: 244.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA047240 Approved "Nucleoplasm,Nucleoli,Nucleoli fibrillar center" NA NA 93000 "Cluster 46: Basophils - DNA binding" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 30: Epithelial cell lines - Translation" "Cluster 27: Mucus-secreting cells - Mucin production" "Nucleoplasm, Nucleoli" "Nucleoli fibrillar center" "HPA047240: " "unprognostic (4.38e-3)" "unprognostic (8.20e-2)" "prognostic favorable (7.13e-5)" "unprognostic (2.97e-1)" "unprognostic (1.32e-1)" "unprognostic (2.40e-2)" "unprognostic (1.08e-2)" "unprognostic (2.11e-1)" "unprognostic (2.99e-1)" "unprognostic (3.14e-1)" "unprognostic (4.84e-2)" "unprognostic (5.00e-2)" "unprognostic (3.83e-2)" "unprognostic (9.49e-2)" "unprognostic (1.78e-1)" "unprognostic (1.63e-1)" "unprognostic (2.58e-1)" 31.2 17.9 6.6 21.5 6.5 15.0 22.4 5.5 7.1 37.8 31.5 74.3 38.4 15.6 41.6 16.4 24.3 32.5 24.8 7.0 11.0 21.6 23.1 17.0 10.6 4.9 10.5 12.0 33.7 26.2 18.9 36.0 10.8 36.7 76.6 10.4 42.4 25.9 10.2 6.0 41.2 23.2 5.3 9.5 64.3 46.6 8.0 10.2 91.8 13.9 15.9 21.8 9.2 6.8 46.6 42.7 34.7 20.9 107.7 75.8 73.5 97.1 94.5 44.7 59.3 109.5 50.5 31.7 31.9 92.9 61.4 22.6 47.1 28.6 73.6 38.4 18.4 38.2 25.0 94.5 123.0 27.9 17.9 47.8 132.5 88.7 158.8 55.5 43.4 29.8 34.8 58.3 85.2 30.9 31.3 22.9 37.0 116.7 27.4 28.2 79.1 18.3 70.6 42.0 25.2 11.9 35.2 52.4 93.7 73.5 22.7 17.2 61.8 37.2 62.3 64.6 47.5 39.5 32.2 25.4 65.7 18.3 46.9 9.2 3.5 4.9 7.5 4.3 7.0 6.4 6.5 8.3 4.7 3.6 6.3 6.2 1.2 5.2 5.2 4.4 5.0 4.2 6.6 6.5 5.5 7.1 7.0 11.0 4.9 10.5 10.8 5.3 8.0 6.8 14.6 51.3 49.5 15.7 29.8 28.4 21.6 31.7 26.7 13.7 50.6 16.5 43.1 42.9 54.5 44.1 12.5 28.6 30.3 184.2 17.6 34.1 123.9 54.4 54.1 17.2 75.1 3.8 49.2 89.5 70.3 37.6 110.1 60.0 24.1 19.2 17.9 53.6 17.0 6.7 56.3 244.0 16.2 10.0 31.4 23.7 23.3 16.0 53.4 27.2 28.1 10.6 13.4 42.7 43.8 66.0 83.3 28.2 82.1 72.3 62.5 30.0 89.7 14.0 19.7 21.6 41.8 134.1 45.3 20.3 21.0 34.3 33.4 15.7 135.3 56.3 GIGYF2 "GYF2, KIAA0642, PARK11, PERQ2, PERQ3, TNRC15" ENSG00000204120 "GRB10 interacting GYF protein 2" Q6Y7W6 2 232697299-232860605 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 333.8;Late spermatids: 563.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA050899, HPA054612, HPA059918, HPA065064" Approved Enhanced Cytosol NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 23: Testis - Cell cycle regulation" "Cluster 1: K-562 - Erythropoiesis" "Cluster 25: Spermatids - Spermatogenesis" Cytosol "HPA050899: AB_2681267, HPA054612: AB_2682542, HPA059918: AB_2684160, HPA065064: AB_2685417" "unprognostic (7.69e-2)" "unprognostic (1.28e-1)" "unprognostic (1.21e-1)" "unprognostic (1.52e-2)" "unprognostic (1.92e-2)" "unprognostic (8.61e-2)" "unprognostic (8.39e-3)" "unprognostic (2.99e-1)" "unprognostic (6.28e-2)" "unprognostic (1.27e-2)" "unprognostic (7.40e-3)" "unprognostic (8.01e-2)" "prognostic favorable (6.97e-5)" "unprognostic (7.53e-2)" "unprognostic (1.78e-1)" "unprognostic (1.20e-2)" "unprognostic (1.66e-1)" 19.1 19.4 13.5 19.1 17.2 21.6 23.1 23.5 14.6 19.0 11.4 17.8 17.6 21.3 13.8 20.4 18.1 15.7 25.6 13.5 18.5 25.2 15.8 16.7 20.4 14.6 13.6 27.4 25.5 40.5 9.6 22.0 15.9 22.0 19.5 22.9 28.4 17.0 37.5 21.2 20.0 18.5 11.4 21.3 21.5 37.9 15.5 24.6 25.9 32.1 21.4 18.6 12.4 21.6 34.3 30.8 37.2 38.1 51.2 44.7 44.1 37.9 36.5 31.3 33.0 30.6 29.6 20.1 9.3 33.5 59.8 36.6 44.2 34.7 41.2 49.4 32.1 71.6 30.5 46.9 36.7 61.3 44.9 31.1 34.6 38.1 59.2 33.6 34.9 33.5 72.8 24.2 33.1 36.5 40.7 24.3 37.5 29.8 25.7 38.7 74.5 27.8 28.6 51.8 33.4 27.5 41.8 30.5 37.7 32.9 29.8 40.1 53.1 33.6 28.6 34.1 29.6 47.6 26.1 40.3 31.6 35.0 31.3 39.2 10.7 13.1 8.0 7.8 10.5 6.1 7.1 7.9 11.2 10.6 8.5 7.9 13.7 13.4 18.9 8.3 10.7 6.4 13.5 17.2 23.5 14.6 13.5 18.5 14.6 13.6 15.9 11.4 15.5 21.6 31.3 57.7 68.4 98.2 26.7 15.7 36.9 25.8 23.9 50.6 29.6 26.0 85.5 25.8 50.8 36.8 60.5 32.2 28.0 28.8 25.4 31.1 333.8 41.2 54.5 36.8 19.2 41.0 105.0 27.3 22.0 36.7 25.0 45.0 17.7 35.4 20.0 28.8 28.5 48.8 131.2 27.9 24.4 29.3 12.1 563.9 37.6 31.8 26.6 98.4 32.9 38.8 42.2 116.6 171.7 29.2 15.0 36.9 39.0 40.6 29.5 18.5 43.3 38.7 26.3 55.0 36.0 128.4 93.4 27.3 19.2 73.2 28.8 46.3 30.3 37.4 GIPC3 "C19orf64, DFNB15, DFNB72, DFNB95" ENSG00000179855 "GIPC PDZ domain containing family member 3" Q8TF64 19 3585478-3593541 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "retina: 16.7" "Group enriched" "Detected in some" 4 "Adipocytes: 10.4;Endothelial cells: 6.2;Hepatic stellate cells: 12.8;Rod photoreceptor cells: 19.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HeLa: 19.0;HMC-1: 11.8;THP-1: 23.1;WM-115: 44.6" "Not detected" "Not detected" "Not detected" "Not detected" HPA067765 Approved "Nucleoplasm,Nuclear bodies,Golgi apparatus" NA NA "Cluster 77: Retina - Visual perception" "Cluster 17: WM-115 - Nervous system development" "Cluster 46: Photoreceptor cells - Phototransduction" Nucleoplasm "Nuclear bodies, Golgi apparatus" "HPA067765: " "unprognostic (1.77e-1)" "unprognostic (1.73e-1)" "unprognostic (5.13e-2)" "unprognostic (6.99e-2)" "unprognostic (1.22e-1)" "unprognostic (1.76e-2)" "unprognostic (1.41e-1)" "unprognostic (3.67e-3)" "unprognostic (4.76e-2)" "unprognostic (2.97e-1)" "unprognostic (5.06e-3)" "unprognostic (2.26e-2)" "unprognostic (1.51e-3)" "unprognostic (1.96e-2)" "unprognostic (1.67e-1)" "unprognostic (2.75e-1)" "unprognostic (9.06e-2)" 4.6 2.2 1.4 1.0 1.0 0.3 2.8 1.0 1.1 3.0 0.8 1.9 1.2 2.8 2.9 5.2 2.1 2.1 3.9 1.2 1.2 3.6 1.4 3.8 2.4 1.6 1.2 0.7 0.7 2.7 1.0 1.1 1.6 3.5 1.4 16.7 0.7 2.3 1.7 1.1 4.4 8.3 1.4 3.9 2.0 0.3 1.6 3.1 3.0 1.9 1.6 1.1 1.8 1.1 0.0 0.1 0.2 0.0 0.0 0.2 0.0 0.3 0.1 0.9 1.7 0.0 0.0 0.0 0.0 0.4 0.0 0.0 4.4 0.0 1.5 0.0 0.2 6.9 19.0 0.0 0.7 0.0 11.8 0.2 0.0 1.1 0.0 0.0 2.1 0.2 3.2 0.0 0.3 0.0 0.0 1.1 0.7 0.0 1.2 0.5 0.0 0.8 0.0 0.0 0.0 0.1 0.5 0.0 4.7 1.1 0.0 23.1 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 44.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 1.0 1.0 1.1 1.2 1.2 1.6 1.2 1.6 1.4 1.6 1.1 10.4 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.6 0.4 0.1 0.3 2.4 0.0 0.0 0.0 2.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 6.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 12.8 0.0 0.5 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.1 0.0 2.8 0.0 0.8 1.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.2 0.0 0.2 1.1 0.0 0.4 0.1 0.3 0.1 0.3 0.1 0.0 0.1 GJA3 "CX46, CZP3" ENSG00000121743 "Gap junction protein alpha 3" Q9Y6H8 13 20138255-20161052 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "heart muscle: 7.8;parathyroid gland: 4.0;placenta: 2.5" "Cell type enriched" "Detected in some" 5 "Cardiomyocytes: 13.6" "Group enriched" "Detected in some" 4 "head and neck cancer: 1.3;melanoma: 3.0" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 4.4;CAPAN-2: 7.7;HL-60: 6.6;U-266/84: 4.7" "Not detected" "Not detected" "Not detected" "Not detected" HPA014821 Supported NA NA "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 54: Cardiomyocytes - Muscle contraction" "HPA014821: AB_2669097" "unprognostic (2.32e-1)" "unprognostic (1.01e-1)" "unprognostic (4.37e-2)" "unprognostic (2.58e-3)" "unprognostic (2.98e-2)" "unprognostic (1.04e-2)" "unprognostic (6.87e-3)" "unprognostic (1.84e-1)" "unprognostic (1.73e-1)" "unprognostic (7.52e-2)" "unprognostic (7.70e-2)" "unprognostic (4.02e-2)" "unprognostic (9.65e-8)" "unprognostic (2.87e-1)" "unprognostic (1.91e-1)" "unprognostic (2.55e-2)" "unprognostic (8.04e-3)" 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.1 7.8 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.3 4.0 0.0 2.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.0 1.2 0.1 0.0 0.1 0.0 1.0 0.0 0.2 0.0 4.4 0.2 0.0 3.7 0.1 1.1 0.0 0.5 3.5 0.6 0.7 0.4 7.7 0.0 0.1 1.3 1.2 0.1 2.5 2.1 0.5 0.2 1.9 1.8 0.0 0.0 0.0 6.6 0.0 0.2 1.2 0.1 0.3 0.0 0.0 2.8 0.5 0.0 0.1 0.0 0.0 0.0 0.5 0.1 1.5 0.3 0.0 0.0 0.0 0.5 0.0 0.0 0.3 0.0 3.7 0.1 0.8 1.4 0.0 0.0 0.0 1.5 0.2 1.7 4.7 0.0 0.0 0.1 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.5 1.2 0.0 0.0 0.0 13.6 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.2 2.7 0.3 0.0 0.0 0.1 0.0 0.0 0.1 GJA8 "CAE, CAE1, CX50, CZP1" ENSG00000121634 "Gap junction protein alpha 8" P48165 1 147902795-147909269 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 46 "testis: 5.8" "Group enriched" "Detected in some" 4 "Early spermatids: 14.6;Spermatocytes: 39.9" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA014715, HPA062940" Enhanced NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA014715: AB_2732411, HPA062940: AB_2732693" "unprognostic (3.73e-2)" "unprognostic (2.35e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 14.6 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.6 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 39.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GJB1 "CMTX, CMTX1, CX32" ENSG00000169562 "Gap junction protein beta 1" P08034 X 71212811-71225516 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Charcot-Marie-Tooth disease, Dejerine-Sottas syndrome, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 100.9;liver: 335.7" "Cell type enhanced" "Detected in many" "Cholangiocytes: 114.4;Hepatocytes: 286.4;Proximal enterocytes: 118.8;Proximal tubular cells: 68.9;Undifferentiated cells: 66.1" "Cancer enhanced" "Detected in many" "liver cancer: 163.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "Hep G2: 143.2;SK-MEL-30: 155.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB012994 Uncertain NA NA "Cluster 15: Liver - Metabolism" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 2: Hepatocytes - Metabolism" "CAB012994: AB_2533228" "unprognostic (2.09e-2)" "unprognostic (1.39e-1)" "unprognostic (8.78e-2)" "unprognostic (2.71e-3)" "unprognostic (2.70e-1)" "unprognostic (4.11e-1)" "unprognostic (2.92e-1)" "unprognostic (3.68e-1)" "unprognostic (2.63e-2)" "unprognostic (2.22e-2)" "unprognostic (7.36e-3)" "unprognostic (1.80e-1)" "prognostic favorable (2.85e-6)" "unprognostic (1.03e-2)" "unprognostic (1.56e-1)" "unprognostic (7.79e-2)" "unprognostic (4.97e-2)" 0.1 0.0 27.1 3.7 63.2 0.0 6.4 76.5 37.6 8.8 12.7 33.9 44.0 1.7 22.5 0.3 27.4 41.5 0.0 27.3 40.9 42.9 335.7 2.4 0.0 90.6 64.4 0.1 83.0 0.0 0.1 0.0 76.0 11.6 23.8 0.0 37.7 7.5 0.0 0.9 34.4 1.8 50.0 0.1 16.4 10.2 56.9 0.0 0.1 0.1 0.0 0.4 0.1 100.9 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 25.5 0.2 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 143.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 5.6 0.0 0.0 0.3 0.0 5.1 0.2 0.0 0.2 0.0 0.0 155.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 1.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 27.1 63.2 76.5 37.6 27.3 40.9 90.6 64.4 76.0 50.0 56.9 100.9 0.0 0.0 4.8 0.3 0.8 0.6 0.7 0.5 0.0 0.0 7.7 2.4 0.1 114.4 2.7 9.2 0.0 0.0 0.1 50.2 9.8 34.1 0.3 8.2 3.4 0.6 9.6 8.0 0.2 58.9 0.0 0.1 15.8 29.0 4.5 0.0 3.3 286.4 0.0 0.0 0.2 29.4 2.0 4.8 0.4 0.4 0.3 0.8 23.2 0.0 0.6 0.0 0.0 1.0 51.3 32.3 53.4 0.4 0.0 2.6 118.8 68.9 0.1 0.0 0.0 0.0 0.4 0.5 0.0 0.0 0.1 0.0 1.0 0.0 66.1 2.8 GJB2 "CX26, DFNA3, DFNB1, NSRD1" ENSG00000165474 "Gap junction protein beta 2" P29033 13 20187463-20192938 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" Hearing "Deafness, Disease variant, Ectodermal dysplasia, Ichthyosis, Non-syndromic deafness, Palmoplantar keratoderma" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "cervix: 328.1;esophagus: 812.1;vagina: 519.8" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 69.8;Basal respiratory cells: 237.4;Basal squamous epithelial cells: 55.8;Ionocytes: 50.8;Squamous epithelial cells: 160.9" "Cancer enhanced" "Detected in all" "head and neck cancer: 447.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 4 "CAPAN-2: 144.6;hTCEpi: 105.4;OE19: 76.9;RT4: 169.9" "Low region specificity" "Detected in all" "CAB013093, HPA014362" Uncertain Approved Mitochondria NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 15: RT4 - Unknown function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Mitochondria "CAB013093: AB_2533903, HPA014362: " "unprognostic (2.21e-1)" "unprognostic (1.25e-3)" "unprognostic (2.43e-2)" "unprognostic (6.14e-2)" "prognostic unfavorable (4.45e-4)" "unprognostic (9.77e-2)" "unprognostic (2.92e-1)" "prognostic unfavorable (6.25e-4)" "unprognostic (1.33e-1)" "unprognostic (3.69e-3)" "prognostic unfavorable (2.90e-4)" "unprognostic (3.22e-2)" "prognostic unfavorable (2.53e-6)" "unprognostic (5.78e-3)" "unprognostic (2.40e-1)" "unprognostic (1.17e-2)" "unprognostic (8.93e-3)" 2.0 0.7 1.3 6.7 1.2 3.8 3.7 2.4 3.1 328.1 5.3 20.8 12.9 2.9 3.4 812.1 0.9 14.0 0.4 1.1 1.7 9.8 47.5 0.7 0.4 1.8 1.7 0.3 1.3 0.1 4.1 0.2 1.7 1.2 17.4 0.0 145.2 0.3 0.4 73.0 10.6 2.6 1.7 0.2 8.1 1.2 7.6 12.5 1.7 1.2 90.4 27.9 519.8 1.6 8.7 0.6 0.0 0.2 0.0 2.9 1.7 0.0 0.0 0.0 0.0 1.3 144.6 0.0 0.7 0.1 1.1 28.9 5.3 14.4 0.1 12.6 1.8 0.1 0.1 0.3 0.0 0.0 5.1 2.4 105.4 1.9 19.5 0.0 0.0 2.1 0.1 10.7 0.2 1.4 1.3 0.0 0.3 76.9 14.4 0.2 0.0 8.3 0.2 169.9 0.1 0.0 0.3 0.1 0.3 1.9 2.2 0.4 0.0 0.2 0.0 2.5 22.2 8.7 9.6 0.0 17.1 0.1 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 1.2 2.4 3.1 1.1 1.7 1.8 1.7 1.7 1.7 7.6 1.6 0.1 3.2 0.0 2.0 0.6 69.8 16.1 237.4 55.8 0.0 1.3 1.3 0.5 4.3 37.3 1.8 0.0 0.1 0.0 28.0 0.0 4.4 1.5 5.0 1.5 1.3 4.2 0.0 0.0 9.8 0.2 1.7 4.1 19.1 0.0 0.0 0.0 25.2 0.6 0.0 0.0 6.1 50.8 0.6 13.3 1.3 0.0 3.9 1.8 0.0 4.6 0.0 0.0 0.0 0.0 9.2 13.3 0.0 2.7 8.6 10.7 17.5 7.5 0.0 0.0 0.1 4.7 0.8 2.1 160.9 28.7 0.1 0.9 0.0 25.0 21.7 GJB3 "CX31, DFNA2, EKV" ENSG00000188910 "Gap junction protein beta 3" O75712 1 34781214-34786369 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Deafness, Disease variant, Non-syndromic deafness, Palmoplantar keratoderma" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "esophagus: 77.8;skin 1: 145.0" "Group enriched" "Detected in many" 5 "Basal keratinocytes: 138.4;Basal prostatic cells: 71.9;Basal respiratory cells: 43.6;Pancreatic endocrine cells: 119.8;Prostatic glandular cells: 63.4;Squamous epithelial cells: 91.9;Suprabasal keratinocytes: 170.6;Urothelial cells: 171.0" "Cancer enhanced" "Detected in many" "head and neck cancer: 58.5" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 88.8;CAPAN-2: 121.7;HaCaT: 99.4;HBEC3-KT: 84.9;hTCEpi: 136.8;OE19: 54.2" "Not detected" "Not detected" "Not detected" "Not detected" HPA074472 Supported "Vesicles,Cell Junctions" NA NA "Cluster 31: Skin - Epidermis development" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 22: Epithelial cell types - Mixed function" "Vesicles, Cell Junctions" "HPA074472: AB_2686694" "unprognostic (1.34e-3)" "unprognostic (2.30e-1)" "unprognostic (2.84e-2)" "unprognostic (5.22e-3)" "unprognostic (3.82e-2)" "unprognostic (2.00e-2)" "unprognostic (1.21e-4)" "prognostic unfavorable (4.56e-4)" "unprognostic (2.30e-1)" "unprognostic (1.29e-1)" "prognostic unfavorable (7.56e-5)" "unprognostic (4.50e-2)" "unprognostic (5.74e-3)" "unprognostic (1.35e-1)" "unprognostic (1.22e-1)" "unprognostic (1.27e-2)" "unprognostic (2.46e-2)" 0.3 0.2 1.3 1.7 0.6 0.0 5.5 1.1 1.0 8.9 0.0 4.2 0.2 0.3 2.8 77.8 1.1 7.0 0.1 0.6 0.0 0.5 1.5 0.6 0.5 0.2 0.0 0.1 0.3 0.0 0.1 1.4 0.1 4.0 5.0 0.0 8.9 1.7 0.6 145.0 1.3 0.1 0.0 0.0 5.9 0.8 0.1 0.8 0.2 0.0 12.9 11.9 26.4 0.2 88.8 2.6 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 121.7 0.0 11.6 0.1 0.1 99.4 0.0 84.9 0.0 0.1 0.0 0.3 5.0 0.0 0.0 0.0 0.0 0.0 136.8 0.0 35.0 0.0 0.0 0.0 0.0 0.1 0.0 4.8 0.0 0.0 0.4 54.2 22.3 0.0 0.0 0.0 40.8 33.0 0.0 0.0 13.1 0.9 0.0 0.1 1.0 0.1 0.0 0.1 5.7 0.0 0.4 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.6 1.1 1.0 0.6 0.0 0.2 0.0 0.1 0.0 0.1 0.2 0.0 3.2 0.0 0.0 0.0 138.4 71.9 43.6 16.5 0.0 2.0 1.3 0.4 1.5 15.5 5.5 0.0 0.3 0.0 18.3 0.0 14.6 0.0 4.1 0.4 1.7 1.8 0.0 0.2 7.3 0.2 1.7 3.1 8.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 2.8 6.1 0.0 12.5 0.0 0.0 0.4 14.2 0.0 0.0 0.0 0.0 0.0 0.0 119.8 8.1 0.0 0.0 63.4 0.5 0.0 10.1 0.0 0.0 0.0 2.1 0.1 0.3 91.9 170.6 0.1 0.5 0.0 19.1 171.0 GJB6 "CX30, DFNA3, ED2, EDH, HED" ENSG00000121742 "Gap junction protein beta 6" O95452 13 20221962-20232365 "Disease related genes, Human disease related genes, Predicted membrane proteins" Hearing "Deafness, Disease variant, Ectodermal dysplasia, Non-syndromic deafness, Palmoplantar keratoderma" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 95.6;esophagus: 195.4;vagina: 139.3" "Cell type enhanced" "Detected in some" "Astrocytes: 58.8;Basal keratinocytes: 12.2;Basal respiratory cells: 15.6;Ionocytes: 12.2;Squamous epithelial cells: 31.0" "Cancer enhanced" "Detected in many" "head and neck cancer: 145.0" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "T-reg: 2.6" "Lineage enriched" "Detected in single" 5 "T-cells: 2.6" "Cell line enriched" "Detected in some" 10 "RT4: 186.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA014846 Supported "Cell Junctions" NA NA "Cluster 20: T-cells - T-cell receptor" "Cluster 27: Brain & Skin - Unknown function" "Cluster 15: RT4 - Unknown function" "Cluster 61: Squamous epithelial cells - Keratinization" "Cell Junctions" "HPA014846: AB_1847135" "unprognostic (5.57e-2)" "unprognostic (1.20e-1)" "unprognostic (3.90e-4)" "unprognostic (7.90e-2)" "unprognostic (2.37e-1)" "unprognostic (1.69e-1)" "unprognostic (1.83e-1)" "unprognostic (8.96e-2)" "unprognostic (9.64e-2)" "unprognostic (2.82e-2)" "unprognostic (2.82e-2)" "unprognostic (3.54e-2)" "unprognostic (1.14e-11)" "unprognostic (8.99e-2)" "unprognostic (1.16e-1)" "unprognostic (6.35e-3)" "unprognostic (5.04e-2)" 0.5 0.2 55.8 0.3 59.4 95.6 3.8 73.0 80.9 65.9 36.0 0.0 0.0 0.9 0.2 195.4 0.4 1.3 0.1 50.2 63.5 0.0 0.1 0.3 0.8 60.0 71.8 0.0 0.1 0.0 4.4 0.0 57.5 0.2 0.1 0.0 34.5 0.0 0.1 56.8 0.2 0.0 47.7 0.2 0.3 1.4 76.3 37.6 5.3 0.0 15.4 10.3 139.3 42.7 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 12.1 0.0 0.0 0.0 0.0 4.0 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 3.0 0.0 0.0 0.0 0.0 0.0 186.3 0.0 0.0 0.0 0.0 0.0 0.6 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.5 1.1 0.6 0.5 0.0 0.0 0.0 2.6 0.2 55.8 59.4 73.0 80.9 50.2 63.5 60.0 71.8 57.5 47.7 76.3 42.7 0.0 0.0 0.0 58.8 0.0 12.2 1.7 15.6 4.0 0.0 0.0 0.1 0.6 0.0 4.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 6.9 5.8 0.4 0.1 0.0 0.0 0.1 0.0 0.1 0.1 0.0 6.6 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 12.2 0.0 0.4 4.6 0.0 0.2 0.0 1.9 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.6 0.0 0.1 0.2 0.0 0.0 0.0 0.4 0.1 0.3 31.0 3.8 0.0 0.3 0.0 0.0 2.4 GJC2 "CX46.6, CX47, GJA12, SPG44" ENSG00000198835 "Gap junction protein gamma 2" Q5T442 1 228149930-228159826 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Disease variant, Hereditary spastic paraplegia, Leukodystrophy, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 9 "brain: 51.3" "Group enriched" "Detected in many" 4 "Cone photoreceptor cells: 12.5;Oligodendrocytes: 26.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "EFO-21: 5.4;SCLC-21H: 2.9;TIME: 2.7" "Region enhanced" "Detected in all" "white matter: 105.5" "Low region specificity" "Detected in all" HPA069619 Supported "Plasma membrane,Cytosol" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 38: EFO-21 - Unknown function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Plasma membrane, Cytosol" "HPA069619: " "unprognostic (2.67e-1)" "unprognostic (1.81e-2)" "unprognostic (6.42e-2)" "unprognostic (8.19e-3)" "unprognostic (4.24e-1)" "unprognostic (1.57e-1)" "unprognostic (6.94e-2)" "unprognostic (2.56e-1)" "unprognostic (4.99e-2)" "unprognostic (7.09e-2)" "unprognostic (7.88e-3)" "unprognostic (9.67e-2)" "unprognostic (6.09e-3)" "unprognostic (2.53e-2)" "unprognostic (7.36e-2)" "unprognostic (1.54e-1)" "unprognostic (2.02e-1)" 2.9 0.9 13.6 0.6 31.2 0.2 1.7 39.0 20.2 4.2 5.2 5.8 0.2 4.7 0.9 1.4 5.4 0.7 1.7 13.9 19.5 1.3 0.5 2.9 0.6 43.9 31.6 3.8 0.5 0.7 1.4 0.5 38.1 3.0 0.3 0.5 0.8 1.7 0.8 1.7 1.7 1.8 28.1 1.4 2.4 1.2 27.6 0.4 2.0 0.8 0.3 4.2 3.5 51.3 0.2 0.2 0.1 0.3 0.8 0.4 1.0 0.8 0.2 0.3 0.4 0.5 0.7 0.1 5.4 1.5 0.4 0.5 0.2 0.2 0.1 0.2 0.9 0.2 1.4 1.2 1.4 0.0 0.0 0.2 0.1 0.5 0.3 0.7 0.1 1.0 0.6 0.1 0.2 0.3 1.1 0.3 0.3 0.0 1.1 0.2 0.1 0.0 0.4 0.0 2.9 1.7 0.2 0.0 0.2 0.1 0.1 0.2 2.7 0.7 2.1 2.5 0.9 0.1 0.4 0.1 0.3 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 13.6 31.2 39.0 20.2 13.9 19.5 43.9 31.6 38.1 28.1 27.6 51.3 2.8 0.0 0.6 0.7 0.2 3.4 1.3 0.6 1.8 2.6 1.3 0.6 1.8 0.0 0.0 0.0 12.5 0.0 0.4 0.2 0.0 0.1 0.2 1.0 1.1 4.3 0.0 0.0 0.8 0.5 0.0 2.2 0.0 1.6 0.0 0.3 3.6 0.0 0.1 3.3 1.1 0.3 0.0 0.6 3.8 0.0 2.5 1.3 1.8 0.0 0.0 0.3 0.0 0.0 26.9 1.1 0.0 4.1 0.0 0.6 0.0 0.0 0.0 1.0 0.0 0.6 1.8 0.0 0.0 0.5 1.7 0.0 0.8 0.6 0.3 1.0 GLE1 "GLE1L, hGLE1, LCCS1" ENSG00000119392 "GLE1 RNA export mediator" Q53GS7 9 128504719-128542288 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "mRNA transport, Protein transport, Translocation, Transport" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 77.0;Late spermatids: 58.1;Spermatocytes: 51.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041689, HPA043538, HPA061560" Supported Supported "Nuclear membrane,Nucleoli" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" "Nuclear membrane" Nucleoli "HPA041689: AB_2677617, HPA043538: AB_2678539, HPA061560: AB_2684560" "unprognostic (8.74e-3)" "unprognostic (2.18e-2)" "unprognostic (1.17e-1)" "prognostic favorable (7.49e-4)" "unprognostic (1.75e-1)" "unprognostic (5.58e-2)" "unprognostic (7.91e-2)" "unprognostic (1.90e-1)" "unprognostic (1.91e-1)" "unprognostic (1.19e-1)" "unprognostic (1.41e-1)" "unprognostic (7.95e-2)" "unprognostic (4.00e-2)" "prognostic favorable (7.04e-4)" "unprognostic (2.62e-1)" "unprognostic (1.99e-3)" "unprognostic (5.64e-2)" 11.6 14.0 9.2 15.7 9.2 15.1 15.7 12.4 11.3 13.0 13.4 17.4 16.2 11.6 10.8 16.4 14.1 7.8 14.9 8.9 8.8 14.1 16.3 12.3 20.4 8.7 9.2 16.2 9.5 17.6 14.1 9.2 8.6 11.8 18.3 16.5 11.1 12.4 22.5 19.1 15.8 12.9 8.4 15.2 12.9 32.0 9.3 25.9 13.3 12.4 22.2 12.8 12.3 8.9 29.6 54.5 26.2 44.9 25.3 25.5 34.6 29.2 24.9 40.2 28.4 36.8 20.1 59.6 23.0 33.0 38.6 101.4 45.9 41.7 34.5 56.9 29.8 30.6 57.8 34.6 28.5 49.9 38.8 18.1 39.7 45.6 48.5 22.3 22.9 54.7 44.7 51.0 46.7 68.6 49.5 35.2 22.2 79.1 46.7 49.8 64.2 79.0 27.3 26.1 30.9 23.1 71.3 42.7 25.9 21.1 78.9 34.9 17.0 42.5 28.1 50.2 41.2 50.9 131.9 45.9 39.9 37.5 46.8 40.0 21.1 24.4 22.1 26.0 18.1 13.4 17.2 20.0 22.1 20.5 15.2 17.7 18.0 27.4 27.5 13.0 22.3 19.8 9.2 9.2 12.4 11.3 8.9 8.8 8.7 9.2 8.6 8.4 9.3 8.9 4.0 9.6 9.0 11.1 11.4 6.5 5.3 10.4 8.6 7.6 8.8 7.6 13.0 5.7 7.2 7.3 8.4 16.1 6.9 13.2 5.9 11.7 77.0 12.2 7.4 3.6 5.4 12.0 14.0 6.2 11.7 7.6 10.2 9.4 9.5 10.9 4.6 14.2 15.7 10.1 15.5 12.7 8.2 15.1 5.7 58.1 10.2 13.5 3.6 10.3 20.0 8.9 15.5 18.1 15.5 8.3 8.0 6.4 13.4 6.1 16.3 13.7 12.6 8.6 13.1 7.7 7.3 51.3 25.5 14.4 6.8 13.3 12.1 7.1 14.1 5.4 GLRA1 STHE ENSG00000145888 "Glycine receptor alpha 1" P23415 5 151822513-151924851 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Chloride channel, Ion channel, Ligand-gated ion channel, Receptor" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 16 "brain: 40.7" "Cell type enhanced" "Detected in some" "Bipolar cells: 7.4;Excitatory neurons: 1.7;Horizontal cells: 1.7;Inhibitory neurons: 5.0;Oligodendrocyte precursor cells: 1.5" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 5 "hypothalamus: 9.4;midbrain: 15.1;pons and medulla: 26.3" "Low region specificity" "Detected in many" CAB079042 Supported NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 56: Bipolar cells - Visual perception" "CAB079042: " "unprognostic (3.17e-1)" "unprognostic (2.47e-1)" "unprognostic (3.85e-7)" "unprognostic (8.24e-2)" "unprognostic (9.45e-3)" 0.0 0.3 1.9 0.0 0.6 0.0 0.0 12.2 1.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 7.0 0.0 0.0 0.0 0.0 40.7 13.9 0.0 0.2 0.0 0.0 0.0 31.4 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 20.9 0.0 0.0 0.0 12.1 0.0 0.0 0.0 0.0 0.0 0.0 10.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.6 12.2 1.8 0.2 7.0 40.7 13.9 31.4 20.9 12.1 10.9 0.0 0.0 0.0 0.7 0.0 0.1 0.9 0.0 0.0 7.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 1.7 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.7 5.0 0.0 0.0 0.0 0.8 0.2 0.0 0.0 0.0 1.0 0.1 0.2 0.0 1.5 1.3 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.7 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.4 0.0 0.0 0.5 GLRB ENSG00000109738 "Glycine receptor beta" P48167 4 157076125-157172090 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Chloride channel, Ion channel, Ligand-gated ion channel, Receptor" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 35.5;parathyroid gland: 33.0" "Group enriched" "Detected in many" 4 "Excitatory neurons: 168.6;Inhibitory neurons: 110.7;Oligodendrocyte precursor cells: 110.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AN3-CA: 28.6;hTERT-RPE1: 37.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA052363 Approved NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA052363: AB_2681800" "unprognostic (7.36e-2)" "unprognostic (6.53e-2)" "unprognostic (1.44e-1)" "unprognostic (2.59e-3)" "unprognostic (5.65e-2)" "unprognostic (1.18e-1)" "unprognostic (9.47e-2)" "unprognostic (1.52e-1)" "unprognostic (1.19e-2)" "unprognostic (2.99e-2)" "unprognostic (6.81e-2)" "unprognostic (1.48e-1)" "prognostic favorable (4.89e-4)" "unprognostic (4.32e-3)" "unprognostic (1.85e-1)" "unprognostic (5.61e-2)" "unprognostic (1.66e-2)" 4.7 7.0 16.5 1.1 17.7 0.2 10.6 7.4 35.5 9.0 4.5 3.3 0.6 2.9 5.2 1.0 7.3 3.2 11.1 18.0 12.9 3.8 1.2 3.1 0.3 9.4 6.9 1.2 15.2 33.0 7.5 2.6 10.8 6.2 0.9 8.5 19.5 4.7 3.3 1.8 1.4 3.7 5.7 0.0 2.9 1.6 9.8 1.1 1.0 4.9 0.2 1.4 1.5 13.5 8.0 3.4 9.5 28.6 18.0 7.2 0.0 16.0 10.1 7.6 14.4 0.0 24.0 0.0 3.7 16.2 9.4 0.0 7.2 2.5 14.3 0.0 9.7 5.0 3.8 0.3 8.1 6.2 0.0 6.4 2.2 13.4 1.9 37.8 6.9 5.1 0.0 0.0 14.1 0.0 0.8 0.0 0.6 0.0 2.3 0.0 13.0 0.0 20.6 1.5 10.3 6.1 0.0 7.3 1.2 1.4 6.8 1.6 10.5 4.5 13.2 7.6 15.3 0.0 0.0 0.0 10.7 0.0 4.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 16.5 17.7 7.4 35.5 18.0 12.9 9.4 6.9 10.8 5.7 9.8 13.5 0.5 0.0 1.1 26.1 0.0 1.1 0.9 3.1 1.2 10.8 7.8 4.8 13.9 4.3 3.5 0.0 2.1 0.4 0.4 0.1 0.0 8.8 0.3 6.9 3.4 2.1 0.0 1.7 168.6 1.8 0.0 3.9 0.0 2.0 1.3 7.0 3.3 0.0 0.1 1.7 110.7 0.0 4.1 0.3 1.9 0.3 0.3 0.1 3.6 15.9 0.6 13.2 0.0 110.1 31.5 1.5 0.0 3.4 0.0 0.6 0.0 0.5 10.4 2.2 0.0 8.5 2.2 1.3 3.3 0.4 0.3 0.1 0.1 1.3 0.1 0.2 GLS "GLS1, KIAA0838" ENSG00000115419 Glutaminase O94925 2 190880821-190965552 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Hydrolase "Cataract, Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "kidney: 316.8" "Cell type enhanced" "Detected in all" "Collecting duct cells: 391.8;Excitatory neurons: 427.1;Proximal tubular cells: 539.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "EFO-21: 907.3;RPTEC TERT1: 419.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036223 Enhanced Supported Mitochondria "Intracellular and membrane" No No 92000 "Cluster 44: Non-specific - Transcription" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 38: EFO-21 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "HPA036223: AB_10669984" "unprognostic (7.45e-2)" "unprognostic (3.42e-2)" "unprognostic (3.21e-1)" "prognostic unfavorable (3.45e-4)" "unprognostic (1.17e-1)" "unprognostic (2.08e-3)" "unprognostic (2.51e-3)" "unprognostic (4.24e-2)" "unprognostic (1.59e-1)" "unprognostic (2.40e-1)" "unprognostic (8.01e-2)" "unprognostic (9.06e-2)" "unprognostic (5.41e-2)" "unprognostic (1.62e-1)" "unprognostic (5.03e-2)" "unprognostic (2.13e-1)" "unprognostic (4.12e-1)" 37.0 77.4 38.5 45.7 50.5 28.7 32.0 40.5 74.6 31.0 35.6 32.0 92.2 28.8 26.6 16.8 25.1 41.8 34.7 55.5 35.9 316.8 11.7 55.6 68.0 44.7 19.8 28.9 36.9 62.0 19.9 35.8 52.5 20.8 30.1 81.8 20.4 31.2 15.8 28.5 103.4 36.9 12.0 49.3 18.7 16.2 24.1 41.7 35.7 23.6 57.9 36.5 23.6 44.8 43.6 47.2 32.4 43.1 99.7 68.9 84.0 126.8 95.7 90.6 103.1 58.1 42.1 88.5 907.3 269.3 46.1 55.6 58.0 50.0 131.5 219.8 37.7 147.3 69.1 72.2 90.8 87.2 66.5 62.9 51.0 71.2 48.4 90.1 119.3 36.7 69.3 175.2 203.3 22.8 59.2 83.7 86.9 25.7 76.7 74.2 83.7 77.4 419.2 78.9 44.9 46.8 172.8 37.9 169.2 115.1 14.9 53.0 85.3 129.4 94.5 65.9 156.8 56.2 138.9 122.1 46.7 70.6 105.5 6.4 1.0 1.9 3.7 1.5 6.5 3.4 4.4 4.8 1.6 3.8 4.5 5.5 2.1 2.8 1.1 3.6 4.1 1.1 38.5 50.5 40.5 74.6 55.5 35.9 44.7 19.8 52.5 12.0 24.1 44.8 81.0 189.1 122.5 61.0 89.3 174.5 44.7 15.6 60.9 93.5 51.8 49.5 38.2 35.8 28.4 391.8 210.6 4.4 128.0 100.6 50.9 21.4 6.6 33.7 66.8 68.3 59.2 17.9 427.1 24.5 15.6 66.0 46.4 97.9 36.8 48.2 63.5 4.3 29.1 26.9 270.5 36.7 14.2 31.2 230.0 7.3 28.6 84.3 88.9 143.4 68.4 11.9 55.6 163.3 146.9 29.8 92.9 43.2 118.4 70.1 165.9 539.1 17.0 111.9 19.7 71.6 76.0 11.3 12.9 61.7 162.8 4.0 114.0 97.8 43.6 56.7 GNAL ENSG00000141404 "G protein subunit alpha L" P38405 18 11689264-11885685 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Transducer "Disease variant, Dystonia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "brain: 99.0" "Cell type enhanced" "Detected in many" "Excitatory neurons: 76.9;Inhibitory neurons: 119.5;Oligodendrocyte precursor cells: 58.8" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in all" "basal ganglia: 99.0" "Immune cell enhanced" "Detected in single" "gdT-cell: 1.3" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "Daudi: 26.4;HeLa: 27.4;U-2 OS: 13.2" "Low region specificity" "Detected in all" "Region enriched" "Detected in many" 14 "basal ganglia: 164.1" "CAB015464, HPA051160" Enhanced Approved Nucleoplasm,Cytosol NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 10: Brain - Neuronal signaling" "Cluster 20: HeLa - Mitochondria" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Cytosol" "CAB015464: AB_831819, HPA051160: AB_2732564" "unprognostic (2.29e-3)" "unprognostic (7.43e-2)" "unprognostic (8.14e-3)" "unprognostic (3.41e-5)" "unprognostic (4.71e-2)" "unprognostic (9.58e-3)" "unprognostic (9.93e-3)" "unprognostic (1.87e-1)" "unprognostic (2.36e-1)" "unprognostic (7.17e-2)" "unprognostic (1.82e-3)" "unprognostic (6.05e-2)" "unprognostic (1.23e-3)" "unprognostic (1.09e-1)" "unprognostic (3.85e-2)" "unprognostic (4.26e-2)" "unprognostic (7.03e-2)" 7.7 1.5 29.2 2.9 99.0 0.8 4.1 3.5 36.7 7.3 0.0 7.1 1.5 6.6 2.2 8.0 3.9 4.6 3.5 39.6 16.7 4.0 2.0 2.7 4.9 8.3 8.9 2.9 1.8 4.8 16.3 2.8 6.8 9.3 3.6 4.1 4.7 17.0 21.7 7.2 3.2 7.5 1.9 2.9 3.1 6.5 14.4 4.3 7.8 13.1 5.5 13.2 7.0 4.8 0.7 8.7 10.3 0.7 0.8 0.2 1.2 0.1 0.4 0.7 0.0 9.2 1.6 26.4 1.6 0.1 5.7 0.4 9.7 8.1 0.0 5.6 9.0 0.2 27.4 5.2 0.1 0.3 0.6 1.2 11.9 0.0 0.2 0.4 0.0 0.3 2.4 0.3 0.3 0.3 0.3 0.8 8.4 7.2 0.2 0.2 1.4 0.2 0.6 0.3 9.4 0.2 12.3 0.6 3.0 2.3 0.2 0.3 1.5 1.1 13.2 0.5 2.6 0.5 0.3 0.1 0.5 0.3 0.3 0.6 0.0 0.1 1.3 0.0 0.0 0.2 0.1 0.8 0.0 0.0 0.0 0.6 0.6 0.1 0.0 0.0 0.0 0.5 29.2 99.0 3.5 36.7 39.6 16.7 8.3 8.9 6.8 1.9 14.4 4.8 4.3 3.2 5.9 17.0 1.1 10.6 11.6 6.6 10.2 7.2 2.4 8.9 3.6 0.0 8.0 3.7 16.7 0.5 13.8 3.2 1.9 0.4 4.2 1.7 3.6 5.7 0.0 0.0 76.9 3.0 3.5 7.2 1.5 3.8 5.7 3.2 1.8 1.9 0.9 3.3 119.5 0.6 30.5 0.8 5.2 2.7 0.9 2.3 14.2 8.4 0.0 1.1 21.6 58.8 3.7 1.2 1.9 3.0 1.7 6.8 1.5 5.0 10.4 3.9 6.6 14.5 10.9 4.3 10.5 11.5 7.5 0.5 2.9 0.3 1.4 15.0 GNAO1 G-ALPHA-o ENSG00000087258 "G protein subunit alpha o1" P09471 16 56191390-56357444 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Transducer "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 171.2;retina: 52.4" "Cell type enhanced" "Detected in many" "Astrocytes: 135.8;Bipolar cells: 189.2;Excitatory neurons: 138.7;Inhibitory neurons: 132.2;Oligodendrocyte precursor cells: 87.9;Oligodendrocytes: 368.3" "Cancer enriched" "Detected in many" 5 "glioma: 11.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ hTERT+: 30.7;BJ hTERT+ SV40 Large T+: 20.0;SCLC-21H: 61.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008387, HPA040878" Enhanced NA NA 510000 "Cluster 65: Brain - Ion transport" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 56: Bipolar cells - Visual perception" "CAB008387: AB_591430, HPA040878: AB_2677184" "unprognostic (1.50e-1)" "unprognostic (1.36e-3)" "unprognostic (8.12e-2)" "unprognostic (1.63e-1)" "unprognostic (2.21e-1)" "unprognostic (3.63e-2)" "unprognostic (6.87e-2)" "unprognostic (1.68e-4)" "unprognostic (3.08e-1)" "unprognostic (1.74e-1)" "prognostic favorable (5.93e-4)" "unprognostic (1.71e-1)" "unprognostic (6.86e-3)" "unprognostic (6.28e-2)" "unprognostic (1.21e-1)" "unprognostic (6.00e-1)" "unprognostic (9.70e-5)" 3.0 7.9 100.8 3.4 171.2 0.1 1.1 55.1 121.9 2.1 0.0 34.0 3.1 7.7 3.0 2.9 2.9 2.5 34.1 101.9 87.6 1.1 10.2 0.9 1.1 74.6 89.6 1.7 3.9 1.5 28.5 0.5 77.9 5.1 5.1 52.4 2.3 16.5 2.0 1.4 7.3 10.2 44.6 1.3 11.0 13.8 107.3 1.1 1.9 0.6 1.1 7.9 2.5 110.3 7.3 0.0 0.6 0.1 0.0 0.1 0.9 7.6 30.7 20.0 9.5 0.4 0.0 0.0 0.2 0.0 7.3 0.6 4.9 0.0 13.7 0.2 0.9 0.0 2.0 0.0 0.0 0.0 2.7 0.1 0.2 0.0 0.0 0.0 0.0 6.1 0.0 0.2 0.0 0.8 0.0 0.1 11.1 0.3 0.1 0.1 7.1 0.1 0.0 0.0 61.2 12.2 12.5 0.2 0.7 3.1 0.2 0.0 0.0 0.2 6.8 0.0 3.6 0.8 0.0 0.1 0.3 0.5 1.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 100.8 171.2 55.1 121.9 101.9 87.6 74.6 89.6 77.9 44.6 107.3 110.3 0.6 0.0 0.5 135.8 0.8 0.8 0.3 0.2 0.0 189.2 1.4 0.6 43.3 1.5 0.1 0.0 6.2 0.4 4.9 0.1 0.0 0.0 26.8 0.7 4.4 1.5 23.3 0.8 138.7 0.0 0.2 6.8 1.5 1.2 0.0 0.2 0.7 10.4 0.1 79.1 132.2 1.0 0.0 0.8 2.1 53.6 34.8 1.7 3.6 13.1 0.0 20.5 1.0 87.9 368.3 0.3 0.0 44.4 2.1 0.4 0.1 0.3 0.1 13.1 0.0 8.2 5.6 15.4 8.8 0.3 0.4 0.1 7.2 0.1 0.3 0.2 GNAT1 CSNBAD3 ENSG00000114349 "G protein subunit alpha transducin 1" P11488 3 50191610-50197696 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Sensory transduction, Vision" Transducer "Congenital stationary night blindness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 904 "retina: 1120.2" "Cell type enriched" "Detected in some" 5 "Rod photoreceptor cells: 2275.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in some" 6 "hippocampal formation: 6.5" "Not detected" "Not detected" HPA045393 Enhanced NA NA "Cluster 79: Retina - Phototransduction" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA045393: AB_2679310" "unprognostic (3.08e-1)" "unprognostic (1.81e-1)" "unprognostic (8.56e-3)" "unprognostic (3.32e-2)" "unprognostic (2.13e-1)" "unprognostic (7.72e-2)" "unprognostic (2.82e-3)" "unprognostic (6.10e-2)" "unprognostic (1.07e-1)" "unprognostic (1.87e-1)" "unprognostic (3.02e-1)" "unprognostic (9.48e-3)" 0.1 0.1 0.3 0.1 0.2 0.7 0.2 0.9 0.4 0.1 0.0 0.1 0.1 0.1 0.4 0.2 0.1 0.1 0.0 0.2 0.1 0.1 0.1 0.1 0.1 0.2 0.2 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.2 1120.2 0.0 0.0 0.1 0.4 0.1 0.1 0.0 0.1 0.1 1.2 0.1 0.1 0.1 0.0 0.1 0.0 0.0 0.4 0.1 0.1 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.2 0.0 0.0 0.0 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.4 0.2 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.2 0.1 0.1 0.5 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.2 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.1 0.1 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.9 0.4 0.2 0.1 0.2 0.2 0.1 0.0 0.1 0.4 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 222.9 0.1 0.1 0.4 0.0 0.0 0.0 241.8 0.0 0.0 0.0 0.0 0.0 14.1 0.1 0.1 13.7 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 90.9 0.0 0.0 0.0 0.0 0.0 38.2 0.6 0.0 0.0 0.0 0.0 397.5 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.0 2275.4 0.0 0.0 0.0 4.7 2.1 0.7 0.0 0.1 0.0 0.1 0.1 0.1 GNAT2 ACHM4 ENSG00000134183 "G protein subunit alpha transducin 2" P19087 1 109603091-109619929 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Sensory transduction, Vision" Transducer "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 21 "retina: 78.8" "Cell type enriched" "Detected in some" 8 "Cone photoreceptor cells: 60.5" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Group enriched" "Detected in some" 4 "basophil: 2.3;eosinophil: 2.5;neutrophil: 3.7" "Lineage enriched" "Detected in single" 5 "granulocytes: 3.7" "Cell line enhanced" "Detected in some" "CACO-2: 4.5;TIME: 5.9" "Not detected" "Not detected" "Low region specificity" "Detected in all" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 79: Retina - Phototransduction" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 9: Photoreceptor cells - Phototransduction" 0.0 0.1 0.4 0.5 0.8 0.4 0.0 0.8 1.1 0.0 3.6 0.1 0.0 0.2 0.0 0.2 0.1 1.0 0.9 0.9 0.1 0.2 0.9 0.1 0.3 0.3 0.2 0.0 0.9 0.2 0.2 0.5 0.6 0.1 0.1 78.8 0.3 0.1 0.2 1.8 0.7 0.1 0.0 0.2 0.2 2.7 0.1 0.1 0.2 0.0 0.1 0.1 0.0 0.3 0.7 0.7 0.5 1.1 0.1 0.1 0.3 0.7 0.1 0.2 0.0 4.5 0.4 1.3 1.8 0.0 0.3 0.4 1.8 0.1 0.3 0.3 0.4 1.2 1.8 0.7 0.0 1.5 0.8 0.4 0.2 0.7 0.3 1.0 0.4 0.5 0.6 0.7 0.2 1.1 0.5 0.4 0.6 0.6 0.4 0.5 0.8 0.8 0.2 2.0 1.2 0.5 1.3 0.4 1.7 2.7 0.9 0.0 5.9 0.3 0.4 1.3 2.5 1.4 2.9 1.7 2.8 0.5 0.5 2.3 0.5 2.5 0.6 0.4 0.6 0.5 0.4 0.4 0.4 0.4 0.4 0.4 3.7 0.4 0.6 0.5 0.3 0.1 0.4 0.8 0.8 1.1 0.9 0.1 0.3 0.2 0.6 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 60.5 0.1 0.0 0.1 0.0 0.0 3.2 0.0 0.0 0.1 0.0 0.0 1.1 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 7.1 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.5 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.1 0.0 1.7 0.0 0.1 0.0 2.8 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 GNB3 ENSG00000111664 "G protein subunit beta 3" P16520 12 6839954-6847393 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" Transducer "Congenital stationary night blindness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 12 "retina: 426.5" "Group enriched" "Detected in many" 7 "Bipolar cells: 471.3;Cone photoreceptor cells: 932.0;Rod photoreceptor cells: 462.8" "Cancer enhanced" "Detected in some" "testis cancer: 3.1" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "Daudi: 14.1;NTERA-2: 17.0;U-698: 40.9" "Low region specificity" "Detected in some" "Region enhanced" "Detected in some" "cerebellum: 5.1" HPA040736 Uncertain Approved "Golgi apparatus,Plasma membrane" NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 79: Retina - Phototransduction" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 9: Photoreceptor cells - Phototransduction" "Plasma membrane" "Golgi apparatus" "HPA040736: AB_2677106" "unprognostic (3.86e-2)" "unprognostic (1.58e-1)" "unprognostic (4.96e-2)" "unprognostic (8.75e-2)" "unprognostic (2.53e-2)" "unprognostic (5.74e-3)" "unprognostic (5.98e-2)" "unprognostic (4.43e-3)" "unprognostic (1.19e-1)" "unprognostic (1.98e-1)" "unprognostic (2.25e-5)" "unprognostic (3.21e-2)" "unprognostic (4.77e-11)" "unprognostic (2.43e-1)" "unprognostic (6.48e-2)" "unprognostic (1.36e-1)" "unprognostic (1.07e-2)" 0.9 1.4 6.3 1.6 6.0 1.0 0.6 6.7 9.5 2.3 6.7 1.4 1.7 2.2 0.7 0.4 1.6 1.1 4.4 5.9 6.6 2.0 0.2 0.7 1.6 5.7 5.3 2.8 0.7 1.5 36.2 0.4 5.6 2.1 0.6 426.5 2.1 1.4 1.3 0.7 1.5 3.2 5.2 0.9 1.0 0.6 5.7 0.3 1.6 0.3 1.6 1.6 1.1 6.4 0.4 1.2 9.4 3.1 1.3 2.0 0.9 4.8 0.8 2.5 2.1 1.9 0.5 14.1 0.1 5.1 0.1 0.5 9.2 0.3 2.3 1.2 2.1 3.4 6.8 1.5 0.9 1.1 2.3 2.4 0.5 2.4 2.7 9.6 2.5 1.8 1.5 1.3 1.2 0.7 0.7 0.8 17.0 0.1 0.5 0.7 2.8 0.9 0.5 0.4 1.1 2.2 0.4 0.1 1.0 2.5 0.1 0.6 4.0 3.2 3.8 4.8 6.7 1.4 1.0 40.9 1.3 0.7 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.3 6.0 6.7 9.5 5.9 6.6 5.7 5.3 5.6 5.2 5.7 6.4 0.3 0.0 0.0 5.2 1.3 0.4 0.4 0.2 1.2 471.3 0.8 1.3 6.1 0.0 0.1 0.0 932.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 2.0 3.3 0.0 1.3 12.3 0.0 0.0 2.3 2.0 0.1 0.0 0.1 1.1 0.0 0.1 74.0 12.4 0.0 4.1 0.3 0.4 0.0 3.7 0.1 1.8 3.7 0.1 86.7 0.0 6.0 1.2 0.1 0.0 3.4 3.2 0.8 0.0 0.1 0.6 462.8 0.0 0.3 1.4 0.1 0.5 0.0 0.0 0.0 0.4 0.2 0.1 0.2 GNB4 ENSG00000114450 "G protein subunit beta 4" Q9HAV0 3 179396088-179451476 "Disease related genes, Human disease related genes, Predicted intracellular proteins, RAS pathway related proteins" Transducer "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hofbauer cells: 81.1;Kupffer cells: 98.1;Macrophages: 66.8;Microglial cells: 91.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HDLM-2: 143.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB018383, CAB018737, HPA040736" Supported Supported "Plasma membrane" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 61: Skin - Cornification" "Cluster 44: HDLM-2 - Immune response" "Cluster 4: Macrophages - Innate immune response" "Plasma membrane" "CAB018383: AB_631542, CAB018737: AB_640712, HPA040736: AB_2677106" "unprognostic (2.56e-2)" "unprognostic (1.95e-1)" "unprognostic (1.62e-1)" "unprognostic (1.01e-1)" "unprognostic (5.97e-3)" "unprognostic (2.12e-1)" "unprognostic (1.44e-2)" "unprognostic (8.28e-2)" "unprognostic (1.16e-1)" "unprognostic (3.44e-1)" "unprognostic (1.56e-1)" "unprognostic (2.32e-2)" "prognostic unfavorable (1.39e-6)" "unprognostic (1.90e-3)" "unprognostic (3.13e-2)" "unprognostic (8.90e-2)" "unprognostic (2.80e-3)" 14.9 6.3 8.7 21.9 19.2 33.7 12.4 7.3 11.2 11.5 2.9 9.5 5.9 9.2 3.7 21.9 7.0 15.2 13.9 9.6 8.7 5.9 7.8 16.0 17.7 15.5 8.5 5.8 2.8 2.7 3.0 21.8 14.5 4.5 8.6 2.0 4.7 4.0 3.1 34.1 6.4 23.5 14.5 18.1 7.4 4.3 10.9 7.9 6.3 5.7 11.5 13.2 6.8 19.7 33.4 15.4 37.7 0.8 23.8 41.5 44.1 46.7 33.1 54.1 61.3 0.8 3.7 61.6 9.9 54.3 49.7 0.6 36.4 43.1 56.7 143.6 29.2 71.3 54.9 0.7 23.4 62.3 16.2 32.9 6.6 42.4 21.6 12.0 59.3 13.7 18.7 0.8 42.8 1.3 32.8 24.3 18.9 0.2 19.3 61.4 49.2 25.3 34.9 1.9 7.0 20.5 37.5 33.0 61.1 23.0 67.5 26.1 45.3 45.1 27.4 13.6 61.6 0.3 0.9 0.8 24.7 52.8 35.4 5.6 21.3 11.0 0.2 27.8 0.1 6.7 0.4 0.3 24.9 13.6 0.4 0.3 14.5 3.4 23.5 12.8 0.6 8.8 8.7 19.2 7.3 11.2 9.6 8.7 15.5 8.5 14.5 14.5 10.9 19.7 40.0 25.6 12.8 17.9 20.1 18.7 1.8 2.5 13.6 1.7 14.3 12.3 15.6 0.0 12.3 3.7 6.2 13.8 11.5 0.1 3.9 1.1 1.2 15.6 22.9 42.9 0.0 22.9 18.6 1.6 18.7 26.6 3.6 10.8 10.8 16.2 53.2 0.9 81.1 1.7 18.4 0.0 2.0 98.1 17.4 1.4 10.2 66.8 14.2 91.8 59.9 0.8 2.1 11.6 7.7 2.8 0.0 15.8 8.1 2.6 0.2 0.2 11.3 4.0 26.3 9.9 41.8 2.3 16.8 23.4 25.4 4.1 2.9 14.7 0.0 1.3 GOSR2 "Bos1, GS27" ENSG00000108433 "Golgi SNAP receptor complex member 2" O14653 17 46923075-46975524 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Protein transport, Transport" "Disease variant, Epilepsy, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 5 "Early spermatids: 303.0;Late spermatids: 796.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "CAB017456, HPA048956, HPA054472" Uncertain Supported "Nucleoplasm,Golgi apparatus" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 23: Testis - Cell cycle regulation" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 34: Spermatids - Unknown function" "Nucleoplasm, Golgi apparatus" "CAB017456: AB_10532285, HPA048956: AB_2680569, HPA054472: AB_2682499" "unprognostic (3.28e-2)" "unprognostic (1.18e-1)" "unprognostic (1.49e-2)" "unprognostic (3.54e-2)" "unprognostic (1.30e-2)" "unprognostic (1.35e-1)" "prognostic unfavorable (3.80e-4)" "unprognostic (7.43e-2)" "unprognostic (2.13e-1)" "unprognostic (2.41e-2)" "unprognostic (7.23e-3)" "unprognostic (2.41e-1)" "unprognostic (2.46e-3)" "unprognostic (4.50e-1)" "unprognostic (3.07e-1)" "unprognostic (2.84e-3)" "unprognostic (4.29e-2)" 23.2 25.6 28.5 21.7 28.7 16.4 24.8 31.6 37.6 24.8 32.9 22.8 49.8 23.8 31.6 21.5 21.3 18.3 32.5 29.3 29.3 42.2 33.9 23.6 26.4 28.7 29.7 26.1 31.3 35.5 37.1 28.7 29.2 23.1 27.4 25.0 32.5 30.5 43.1 21.9 43.2 29.8 28.1 30.1 23.1 48.3 29.5 27.1 26.6 34.3 31.8 25.2 18.6 30.9 44.6 47.2 33.5 40.3 54.9 39.3 37.8 59.7 58.5 63.5 56.7 60.1 25.7 37.7 33.1 75.4 66.5 30.1 43.4 48.5 77.8 83.0 33.3 56.8 37.4 60.1 60.3 44.9 44.1 40.8 47.1 52.2 73.2 49.0 52.6 43.7 56.5 50.9 46.2 46.8 50.0 24.2 31.1 60.1 65.8 43.5 64.0 44.5 40.7 37.7 28.8 61.5 33.3 19.2 47.9 57.1 55.1 31.3 62.1 60.0 38.8 47.4 58.9 64.6 39.4 60.1 56.1 28.6 67.1 39.5 33.1 29.2 33.9 63.2 31.3 29.8 29.7 27.8 32.7 38.6 29.1 25.4 3.6 31.2 86.0 29.7 38.8 35.2 28.5 28.7 31.6 37.6 29.3 29.3 28.7 29.7 29.2 28.1 29.5 30.9 23.7 25.6 18.7 17.9 22.0 16.6 17.3 16.7 4.6 18.5 21.1 18.0 16.2 15.7 14.5 33.1 6.2 30.2 23.8 15.9 23.5 34.5 303.0 9.1 18.0 25.2 7.2 20.6 24.2 42.7 33.1 18.4 15.3 11.0 14.5 22.7 21.8 22.4 45.1 23.5 26.3 16.8 16.2 22.0 14.7 796.1 16.8 15.0 10.6 21.5 22.0 16.4 14.4 17.1 28.4 58.1 24.2 14.3 23.5 22.1 96.5 90.0 13.7 20.4 0.0 9.3 26.8 33.1 26.7 7.4 16.9 52.7 14.9 18.4 12.6 20.5 GOT2 "KAT4, KATIV, KYAT4, mitAAT" ENSG00000125166 "Glutamic-oxaloacetic transaminase 2" P00505 16 58707131-58734342 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Lipid transport, Transport" "Aminotransferase, Transferase" "Cancer-related genes, Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 698.4;tongue: 726.8" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 341.9;Hepatocytes: 176.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018139, HPA058537" Enhanced "Intracellular and membrane" NA NA 2800000 "Cluster 13: T-cells - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 54: Cardiomyocytes - Muscle contraction" "HPA018139: AB_1849903, HPA058537: " "unprognostic (1.50e-2)" "unprognostic (4.79e-2)" "unprognostic (2.73e-3)" "unprognostic (2.63e-3)" "unprognostic (3.02e-2)" "prognostic unfavorable (1.61e-4)" "prognostic favorable (5.75e-5)" "unprognostic (1.12e-2)" "unprognostic (3.19e-1)" "unprognostic (3.72e-2)" "unprognostic (2.27e-1)" "unprognostic (3.00e-1)" "prognostic favorable (2.90e-9)" "unprognostic (1.16e-1)" "unprognostic (1.48e-1)" "unprognostic (5.56e-2)" "unprognostic (2.22e-1)" 19.6 73.9 52.4 27.4 55.9 21.1 36.3 62.5 66.9 34.1 129.4 57.6 37.4 36.5 66.3 66.9 46.7 24.1 313.2 57.9 59.3 88.0 321.4 25.2 35.6 60.6 51.0 29.4 33.2 98.6 46.7 24.7 62.5 59.0 65.0 91.4 47.7 65.7 698.4 41.1 35.7 46.7 50.1 28.5 54.9 28.9 58.7 35.9 42.6 726.8 57.0 57.0 45.1 61.0 137.2 182.4 93.8 114.8 66.6 59.8 122.0 101.4 108.8 197.6 107.7 158.9 120.1 302.3 117.3 114.6 86.5 195.5 203.2 199.2 250.1 83.1 182.0 81.4 92.1 179.3 84.2 132.3 71.9 58.4 110.9 125.2 108.2 112.4 201.8 141.9 167.0 30.6 102.2 122.5 164.0 128.0 127.7 90.8 338.0 177.8 142.7 291.1 187.9 197.7 148.2 107.6 195.2 208.5 74.8 84.2 105.5 42.7 82.3 71.4 129.3 56.2 132.4 69.9 68.6 247.4 76.7 130.9 73.8 4.6 20.6 7.4 28.3 16.9 43.7 26.5 33.1 34.1 34.7 22.3 30.1 28.4 1.8 30.2 18.4 30.0 48.7 31.2 52.4 55.9 62.5 66.9 57.9 59.3 60.6 51.0 62.5 50.1 58.7 61.0 15.1 9.6 15.8 11.8 19.8 32.0 37.0 39.4 34.1 34.5 27.5 16.3 341.9 22.8 22.5 36.8 77.2 42.6 11.8 42.6 56.7 50.8 4.0 30.4 20.0 23.8 20.5 39.3 24.7 42.5 38.8 21.1 30.1 25.4 14.5 37.5 23.2 176.1 39.1 20.2 27.1 33.5 26.4 17.0 15.1 8.1 18.0 13.5 24.9 5.6 12.7 16.1 8.2 11.6 17.6 40.3 13.3 22.6 39.2 38.2 27.6 63.2 17.5 48.9 0.0 15.2 24.0 11.9 15.0 68.9 30.0 23.7 17.4 36.4 54.4 69.6 GPR143 OA1 ENSG00000101850 "G protein-coupled receptor 143" P51810 X 9725346-9786297 "Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "G-protein coupled receptor, Receptor, Transducer" "Albinism, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 14.2;choroid plexus: 14.4" "Group enriched" "Detected in many" 8 "Cytotrophoblasts: 40.6;Melanocytes: 126.3" "Cancer enriched" "Detected in all" 9 "melanoma: 84.0" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 9 "basophil: 3.1" "Lineage enriched" "Detected in single" 19 "granulocytes: 3.1" "Cell line enriched" "Detected in some" 7 "SK-MEL-30: 159.6" "Not detected" "Not detected" "Not detected" "Not detected" HPA003648 Enhanced NA NA "Cluster 34: Basophils - Unknown function" "Cluster 27: Brain & Skin - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 47: Cytotrophoblasts - Unknown function" "HPA003648: AB_2667028" "unprognostic (4.60e-2)" "prognostic favorable (8.73e-4)" "unprognostic (7.43e-3)" "unprognostic (5.41e-2)" "unprognostic (4.62e-3)" "unprognostic (2.00e-2)" "unprognostic (3.05e-1)" "unprognostic (2.64e-3)" "unprognostic (3.78e-1)" "unprognostic (5.89e-2)" "unprognostic (8.18e-2)" "unprognostic (8.40e-2)" "prognostic favorable (2.45e-5)" "unprognostic (2.75e-1)" "unprognostic (2.07e-1)" "unprognostic (8.76e-2)" "unprognostic (1.59e-2)" 0.6 1.1 10.6 0.1 13.0 0.0 1.7 11.8 11.5 2.0 14.4 1.4 0.5 3.2 5.3 2.4 2.8 0.9 0.1 10.8 13.1 4.6 1.7 1.0 0.5 12.6 14.2 3.3 1.2 2.9 2.7 6.1 12.3 2.6 1.4 0.9 3.3 4.4 0.0 8.9 0.5 1.0 11.4 0.0 0.7 0.8 13.1 1.8 3.2 0.0 1.6 1.1 1.1 12.2 1.9 0.4 4.6 0.2 0.0 0.0 3.7 0.0 0.0 0.0 0.0 2.1 0.1 0.0 0.2 0.0 0.4 0.1 0.2 1.1 0.1 0.1 0.3 0.0 0.2 0.6 2.3 0.0 3.4 0.1 1.6 0.0 0.0 24.2 6.7 0.0 0.0 0.0 0.0 12.1 0.0 0.1 11.1 0.0 0.1 0.0 0.1 0.1 22.2 3.2 0.9 0.0 0.3 0.0 159.6 10.8 1.9 0.0 4.6 0.0 0.2 0.0 0.1 0.0 0.1 0.1 0.0 0.1 0.4 3.1 0.1 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 10.6 13.0 11.8 11.5 10.8 13.1 12.6 14.2 12.3 11.4 13.1 12.2 0.1 0.0 0.0 9.8 0.2 5.5 1.3 1.8 2.2 0.5 2.1 1.7 0.9 0.0 4.9 7.3 0.0 40.6 0.0 0.8 1.9 4.9 0.2 1.7 1.6 1.5 0.0 0.0 0.6 0.6 2.1 1.0 0.0 1.3 0.0 1.8 2.9 0.3 4.8 0.0 0.3 0.8 2.0 0.0 1.6 1.8 1.8 0.1 126.3 1.0 0.0 1.2 0.0 0.5 0.6 1.2 0.2 6.4 0.0 1.8 0.2 5.0 3.2 0.2 0.0 0.0 0.7 0.2 1.3 4.2 0.6 10.1 0.7 1.0 2.0 1.8 GPR179 "CSNB1E, GPR158L1" ENSG00000277399 "G protein-coupled receptor 179" 17 38324571-38343956 "Human disease related genes, Predicted membrane proteins" "Evidence at transcript level" "Evidence at transcript level" "Tissue enriched" "Detected in some" 8 "retina: 13.9" "Cell type enriched" "Detected in some" 11 "Bipolar cells: 25.1" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" HPA017885 Uncertain NA NA "Cluster 77: Retina - Visual perception" "Cluster 56: Bipolar cells - Visual perception" "HPA017885: AB_2279357" "unprognostic (1.65e-1)" "unprognostic (2.27e-1)" "unprognostic (1.24e-4)" "unprognostic (8.89e-3)" "unprognostic (1.34e-1)" "unprognostic (1.09e-1)" "unprognostic (2.10e-1)" "unprognostic (3.04e-2)" "unprognostic (4.76e-2)" "unprognostic (2.34e-2)" "unprognostic (6.57e-3)" "unprognostic (5.31e-2)" "unprognostic (5.09e-10)" "unprognostic (6.18e-2)" "unprognostic (2.31e-1)" "unprognostic (1.62e-2)" "unprognostic (3.41e-4)" 0.0 0.0 1.2 0.0 0.6 0.0 0.0 0.2 0.8 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 1.1 1.7 0.0 0.0 0.0 0.0 0.3 1.1 0.1 0.0 0.0 0.1 0.0 0.5 0.0 0.0 13.9 0.0 0.0 0.3 0.0 0.0 0.0 1.4 0.0 0.0 0.4 1.8 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.6 0.2 0.8 1.1 1.7 0.3 1.1 0.5 1.4 1.8 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 25.1 0.0 0.0 0.7 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GPR88 ENSG00000181656 "G protein-coupled receptor 88" Q9GZN0 1 100538139-100542021 "Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins" "G-protein coupled receptor, Receptor, Transducer" "Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 9 "brain: 93.9" "Cell type enhanced" "Detected in some" "Breast glandular cells: 1.1;Excitatory neurons: 1.8;Hepatocytes: 2.2" "Cancer enriched" "Detected in some" 9 "liver cancer: 12.0" "Region enriched" "Detected in many" 7 "basal ganglia: 93.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "HSkMC: 1.6;SCLC-21H: 2.0" "Region enriched" "Detected in many" 10 "basal ganglia: 718.8" "Region enriched" "Detected in many" 42 "basal ganglia: 273.1" HPA007488 Approved NA NA "Cluster 65: Brain - Ion transport" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 15: Hepatocytes - Hemostasis" "HPA007488: AB_2667844" "unprognostic (1.65e-1)" "unprognostic (1.50e-1)" "unprognostic (8.30e-2)" "unprognostic (8.37e-3)" "unprognostic (5.41e-1)" "unprognostic (5.63e-2)" "unprognostic (1.82e-1)" "unprognostic (1.28e-1)" "unprognostic (1.03e-2)" "unprognostic (7.76e-2)" "unprognostic (8.23e-3)" "unprognostic (2.45e-1)" "unprognostic (3.93e-4)" "unprognostic (1.85e-2)" "unprognostic (5.56e-2)" "unprognostic (4.41e-1)" "unprognostic (1.35e-2)" 0.4 0.3 4.8 0.3 93.9 0.0 7.2 0.1 14.4 0.1 0.1 0.9 0.3 0.1 0.0 0.1 0.1 0.0 0.2 3.1 2.6 0.1 8.9 0.1 0.1 10.1 1.4 2.6 0.0 1.0 1.1 0.0 1.0 0.3 0.3 0.3 0.4 0.0 0.2 0.0 0.4 0.1 0.9 10.5 0.2 0.1 7.5 0.2 0.1 0.2 0.0 0.0 0.1 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.8 93.9 0.1 14.4 3.1 2.6 10.1 1.4 1.0 0.9 7.5 1.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 1.1 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.9 0.0 0.1 0.0 0.0 0.0 2.2 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.4 0.0 0.2 0.0 0.0 0.0 0.7 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.2 0.0 0.1 0.2 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GPSM2 "DFNB82, LGN, Pins" ENSG00000121957 "G protein signaling modulator 2" P81274 1 108875350-108934545 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Cell cycle, Cell division, Mitosis, Transport" Deafness "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 46.9;tongue: 54.4" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 133.5;Oligodendrocyte precursor cells: 134.7;Oligodendrocytes: 127.4;Syncytiotrophoblasts: 89.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 5 "eosinophil: 3.2;T-reg: 1.8" "Group enriched" "Detected in many" 5 "granulocytes: 3.2;T-cells: 1.8" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007327, HPA008408, CAB018962" Uncertain Supported Cytosol NA Yes "Cluster 52: Eosinophils - Transcription" "Cluster 27: Brain & Skin - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 68: Oligodendrocytes - Mixed function" Cytosol "CAB018962: , HPA007327: AB_1849941, HPA008408: AB_1849939" "unprognostic (1.97e-1)" "unprognostic (6.80e-2)" "prognostic favorable (7.86e-5)" "unprognostic (1.37e-3)" "unprognostic (3.18e-2)" "unprognostic (1.97e-2)" "unprognostic (8.57e-6)" "unprognostic (7.12e-2)" "unprognostic (2.76e-2)" "unprognostic (3.92e-2)" "prognostic unfavorable (5.89e-4)" "unprognostic (7.55e-3)" "prognostic unfavorable (3.02e-4)" "unprognostic (6.27e-3)" "unprognostic (1.00e-1)" "unprognostic (5.14e-3)" "unprognostic (6.00e-2)" 5.3 3.5 27.3 4.4 39.5 14.4 7.5 33.8 25.2 12.6 10.8 15.3 9.1 6.8 2.6 34.1 4.2 2.6 4.3 23.3 29.5 2.3 2.9 9.0 6.4 33.9 36.3 3.3 3.6 9.7 3.1 7.7 33.9 5.9 15.2 8.6 10.1 4.7 10.7 37.7 11.5 10.5 32.1 2.7 5.1 11.5 34.1 18.4 3.2 54.4 13.2 6.0 17.7 46.9 135.6 16.2 36.8 27.7 36.4 20.2 30.0 24.2 61.4 29.9 45.4 16.0 31.7 30.5 6.7 33.4 21.0 28.3 25.3 59.1 39.6 30.7 15.8 19.8 34.7 16.5 4.8 28.6 18.5 4.1 113.9 29.4 129.8 9.4 26.9 19.5 14.9 42.3 58.4 37.8 26.1 12.2 8.7 52.1 29.4 20.1 66.7 6.6 24.3 18.6 30.4 26.9 37.0 69.2 26.9 10.3 27.6 24.3 18.0 21.7 36.7 64.8 48.5 18.4 20.9 28.6 34.3 47.4 108.9 0.1 0.3 3.2 0.2 0.3 0.1 0.2 0.2 0.2 0.3 0.4 0.4 0.3 0.3 0.1 0.1 0.1 1.8 0.1 27.3 39.5 33.8 25.2 23.3 29.5 33.9 36.3 33.9 32.1 34.1 46.9 4.6 16.0 3.3 63.0 5.7 62.7 18.8 12.9 47.3 47.7 3.0 3.7 2.5 2.8 12.5 7.3 133.5 46.3 6.7 10.8 11.7 2.5 54.0 5.2 20.6 5.1 9.1 33.9 11.7 1.9 47.7 19.5 8.6 9.2 2.5 14.4 2.9 1.6 9.0 43.7 24.0 14.1 10.2 5.3 11.3 21.3 18.6 4.9 26.6 3.7 5.3 8.0 2.1 134.7 127.4 4.8 7.8 5.3 5.3 5.6 8.4 0.9 9.0 48.1 0.0 43.6 6.9 20.6 28.9 24.0 40.6 89.2 7.1 10.0 18.7 15.5 GRAP ENSG00000154016 "GRB2 related adaptor protein" Q13588 17 19020656-19047011 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 37.5" "Cell type enhanced" "Detected in some" "Adipocytes: 11.2;B-cells: 21.2;Endothelial cells: 19.8;Hepatic stellate cells: 30.7;Microglial cells: 9.4" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in all" 5 "B-cells: 99.7;T-cells: 133.6" "Cell line enhanced" "Detected in some" "Daudi: 87.1;HUVEC TERT2: 38.9;JURKAT: 30.1;REH: 47.8;TIME: 70.4;U-698: 60.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046595, HPA066654" Uncertain Approved Centrosome NA NA 1400000 "Cluster 32: T-cells - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Centrosome "HPA046595: AB_10966385, HPA066654: AB_2685699" "unprognostic (3.02e-1)" "unprognostic (6.85e-2)" "unprognostic (6.25e-2)" "unprognostic (2.78e-2)" "unprognostic (3.43e-2)" "unprognostic (3.86e-6)" "unprognostic (1.01e-1)" "unprognostic (1.02e-1)" "unprognostic (4.03e-3)" "unprognostic (1.85e-1)" "unprognostic (4.38e-2)" "unprognostic (5.11e-2)" "unprognostic (2.67e-5)" "unprognostic (2.25e-1)" "unprognostic (1.57e-2)" "unprognostic (2.16e-1)" "unprognostic (5.77e-3)" 6.3 3.5 6.7 13.9 6.2 6.5 5.9 6.1 6.9 3.9 5.0 2.6 1.9 3.3 0.5 1.8 4.6 5.3 3.7 5.8 6.1 4.9 6.0 7.1 36.9 6.8 6.5 1.8 0.9 0.6 1.9 6.1 6.8 2.7 1.8 0.4 1.6 3.7 1.7 2.4 15.7 3.3 6.5 37.5 2.2 6.3 7.0 31.9 5.5 1.4 30.7 3.6 2.2 6.0 0.0 0.2 4.5 0.0 0.0 0.1 1.7 0.1 0.0 0.0 0.0 0.1 0.0 87.1 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 5.2 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.0 38.9 30.1 0.2 0.0 0.0 0.2 19.9 1.9 0.9 0.0 0.0 47.8 0.0 9.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.9 0.0 6.8 70.4 0.0 0.2 9.8 0.1 0.1 0.0 60.2 0.1 0.1 0.3 21.5 9.4 1.3 21.5 4.8 21.5 99.7 67.4 28.4 10.5 82.7 133.6 66.5 2.9 21.4 0.4 7.9 62.3 48.9 6.7 6.2 6.1 6.9 5.8 6.1 6.8 6.5 6.8 6.5 7.0 6.0 11.2 6.4 1.8 0.0 21.2 1.0 0.0 0.0 0.0 0.0 0.4 0.6 0.2 0.0 0.6 0.0 0.0 0.1 3.1 0.0 0.0 0.3 2.3 1.1 0.2 19.8 0.0 4.0 0.0 0.0 0.7 0.4 0.0 1.2 2.5 0.1 30.7 0.8 8.2 0.0 0.0 0.4 0.0 4.4 0.7 0.8 0.0 1.9 0.0 9.4 2.9 0.2 2.1 0.0 0.1 0.2 0.0 0.4 3.0 0.0 0.0 0.1 0.0 0.3 0.0 0.3 0.3 0.7 0.3 0.0 1.0 0.3 6.9 0.5 0.3 0.0 GRHL2 "BOM, DFNA28, FLJ13782, TFCP2L3" ENSG00000083307 "Grainyhead like transcription factor 2" Q6ISB3 8 101492439-101669726 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding" "Corneal dystrophy, Deafness, Disease variant, Dwarfism, Ectodermal dysplasia, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skin 1: 28.6" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 32.1;Respiratory ciliated cells: 28.8;Squamous epithelial cells: 27.1;Suprabasal keratinocytes: 26.0" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 39.3;CACO-2: 28.0;HaCaT: 46.3;hTCEpi: 35.5;MCF7: 32.7;OE19: 37.9;RT4: 68.9;T-47d: 79.7" "Not detected" "Not detected" "Not detected" "Not detected" "HPA004820, HPA062839" Uncertain Supported Nucleoplasm NA NA "Cluster 30: Epididymis - Antimicrobial activity" "Cluster 15: RT4 - Unknown function" "Cluster 44: Endometrium - Transcription" Nucleoplasm "HPA004820: AB_1857928, HPA062839: AB_2684878" "prognostic unfavorable (6.43e-4)" "unprognostic (2.54e-2)" "unprognostic (4.09e-2)" "unprognostic (2.95e-2)" "unprognostic (2.68e-1)" "unprognostic (4.79e-2)" "unprognostic (1.90e-1)" "unprognostic (2.66e-1)" "unprognostic (1.64e-1)" "unprognostic (8.59e-2)" "prognostic unfavorable (6.27e-4)" "unprognostic (2.61e-2)" "unprognostic (8.29e-4)" "unprognostic (4.54e-3)" "unprognostic (2.64e-1)" "unprognostic (1.08e-1)" "unprognostic (1.03e-2)" 0.1 0.0 0.0 1.0 0.0 0.0 12.3 0.0 0.3 6.9 0.0 8.0 4.0 1.7 16.1 20.4 8.5 3.3 0.0 0.0 0.0 6.3 0.4 5.6 0.0 0.0 0.0 0.0 11.1 9.3 0.8 6.7 0.0 23.2 9.2 0.0 14.8 7.2 0.0 28.6 4.3 0.4 0.0 0.1 9.8 0.3 0.0 2.9 10.2 0.0 4.6 7.7 10.4 0.0 39.3 0.0 0.0 0.0 0.0 0.0 19.5 0.0 0.0 0.0 0.0 28.0 18.9 0.0 0.0 0.1 0.0 46.3 0.0 22.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 35.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 32.7 0.0 0.3 0.2 37.9 0.0 0.0 0.0 0.1 0.0 68.9 1.9 0.0 0.0 15.0 0.0 4.4 79.7 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 32.1 13.0 0.3 0.0 24.3 10.5 7.6 20.5 0.0 14.4 6.1 0.7 17.2 20.8 11.0 0.0 14.0 0.2 10.3 5.9 7.5 2.4 20.0 1.5 0.8 1.2 0.0 0.8 5.5 7.1 0.8 15.3 20.7 0.0 0.0 0.0 0.0 1.4 0.0 1.3 9.8 2.0 0.0 1.1 9.3 0.0 0.3 1.8 0.0 0.6 0.0 0.0 2.0 0.5 8.8 8.5 0.0 1.3 9.3 5.7 0.1 28.8 0.0 0.0 0.5 1.0 0.1 0.0 27.1 26.0 19.8 0.3 0.1 11.0 6.3 GRID2 "GluD2, GluR-delta-2" ENSG00000152208 "Glutamate ionotropic receptor delta type subunit 2" O43424 4 92303966-93810157 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Ion transport, Transport" "Ion channel, Ligand-gated ion channel, Receptor" Neurodegeneration "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 8 "brain: 40.2;testis: 34.0" "Cell type enhanced" "Detected in some" "Early spermatids: 380.6;Excitatory neurons: 787.2;Inhibitory neurons: 982.0;Late spermatids: 674.2;Microglial cells: 382.2;Oligodendrocyte precursor cells: 2319.7;Oligodendrocytes: 453.5" "Cancer enriched" "Detected in single" 7 "glioma: 1.8" "Region enhanced" "Detected in all" "cerebellum: 40.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "U-2 OS: 7.7;U-266/70: 3.5" "Low region specificity" "Detected in all" "Region enriched" "Detected in all" 5 "cerebellum: 68.3" "HPA056253, HPA058538" Enhanced NA NA "Cluster 21: Non-specific - Transcription" "Cluster 9: U-2 OS - Unknown function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA056253: AB_2683079, HPA058538: AB_2683747" "unprognostic (2.78e-1)" "unprognostic (1.29e-4)" "unprognostic (7.23e-3)" "unprognostic (1.24e-1)" "unprognostic (2.15e-1)" "unprognostic (3.50e-2)" "unprognostic (3.34e-1)" "unprognostic (6.92e-2)" "unprognostic (7.96e-3)" "unprognostic (4.36e-2)" "unprognostic (9.31e-2)" "unprognostic (7.38e-3)" 0.0 2.2 5.6 0.0 6.2 0.0 0.0 40.2 4.0 0.4 0.0 0.0 0.1 0.0 0.2 0.0 0.2 0.0 0.1 3.1 10.7 0.1 0.0 0.0 0.0 4.6 5.3 2.4 0.0 0.0 0.0 0.0 4.8 0.0 0.0 4.9 0.0 0.2 0.0 0.0 0.1 0.0 3.4 0.0 0.1 34.0 14.2 0.0 0.0 0.2 0.0 0.1 0.1 3.8 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 7.7 0.0 0.0 3.5 0.0 0.3 0.3 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.6 6.2 40.2 4.0 3.1 10.7 4.6 5.3 4.8 3.4 14.2 3.8 0.0 0.0 0.0 86.8 0.0 0.0 0.0 0.0 2.2 108.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 380.6 0.0 0.1 1.5 0.0 0.0 787.2 0.0 0.0 0.3 0.0 0.0 0.0 3.3 0.0 0.0 0.1 28.6 982.0 0.0 0.0 0.0 0.0 674.2 5.0 0.2 0.0 382.2 0.0 115.3 0.0 2319.7 453.5 0.0 0.0 1.2 0.0 0.1 0.0 0.0 0.0 7.7 6.6 0.0 1.2 3.7 2.9 0.2 0.0 0.0 0.0 6.4 0.0 0.0 GRIN2A "GluN2A, NMDAR2A" ENSG00000183454 "Glutamate ionotropic receptor NMDA type subunit 2A" Q12879 16 9753404-10182928 "Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins, Transporters" "Ion transport, Transport" "Ion channel, Ligand-gated ion channel, Receptor" "Cancer-related genes, Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 10 "brain: 31.7" "Group enriched" "Detected in some" 13 "Excitatory neurons: 839.8;Inhibitory neurons: 904.7" "Cancer enhanced" "Detected in some" "ovarian cancer: 0.9" "Region enhanced" "Detected in many" "cerebral cortex: 31.7" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ hTERT+ SV40 Large T+ RasG12V: 1.1;fHDF/TERT166: 4.4;hTERT-RPE1: 1.4;RPMI-8226: 1.8;U-138 MG: 4.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB022725 Enhanced NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB022725: " "unprognostic (6.43e-2)" "unprognostic (2.47e-1)" "unprognostic (5.97e-2)" "unprognostic (3.21e-2)" "unprognostic (3.13e-2)" "unprognostic (1.59e-2)" "unprognostic (1.62e-1)" "unprognostic (2.10e-1)" "unprognostic (2.08e-1)" "unprognostic (5.39e-2)" "unprognostic (1.47e-1)" "unprognostic (1.69e-1)" "unprognostic (3.75e-3)" "unprognostic (4.79e-3)" "unprognostic (2.05e-1)" "unprognostic (3.92e-3)" "unprognostic (3.33e-2)" 0.3 0.3 4.7 0.0 8.4 0.0 0.1 0.0 31.7 0.3 0.0 0.2 0.3 0.3 2.5 1.1 2.1 0.1 3.0 20.0 0.0 0.4 0.0 0.4 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.0 0.0 0.1 0.2 2.2 0.2 0.3 0.0 0.5 0.2 0.4 0.0 0.0 0.4 2.1 0.1 0.6 0.2 0.2 0.2 0.1 0.4 10.3 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 1.0 0.3 1.1 0.0 0.0 0.0 0.0 4.4 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.2 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 4.6 0.3 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.7 8.4 0.0 31.7 20.0 0.0 0.0 0.0 0.0 0.0 0.1 10.3 0.2 0.0 0.0 16.0 0.0 1.9 2.2 0.5 3.4 10.3 0.3 0.0 18.2 0.0 0.0 0.0 4.2 0.0 0.0 0.0 0.0 2.1 17.2 0.3 0.1 0.5 0.0 0.0 839.8 0.2 0.0 2.7 0.0 0.7 0.0 3.3 0.0 0.3 0.1 1.7 904.7 0.0 0.0 0.3 0.4 15.1 0.9 0.1 0.0 15.9 0.0 15.6 0.0 27.6 65.8 0.7 0.0 0.0 0.0 0.7 0.0 0.0 0.0 13.9 0.0 0.0 5.4 8.2 10.0 0.2 0.4 0.0 0.0 0.0 0.1 0.3 GRIN2B "GluN2B, NMDAR2B" ENSG00000273079 "Glutamate ionotropic receptor NMDA type subunit 2B" Q13224 12 13437942-13982002 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Ion transport, Transport" "Ion channel, Ligand-gated ion channel, Receptor" "Disease variant, Epilepsy, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 85 "brain: 36.1" "Group enriched" "Detected in some" 4 "Excitatory neurons: 625.2;Inhibitory neurons: 882.5" "Not detected" "Not detected" "Group enriched" "Detected in many" 34 "amygdala: 11.5;basal ganglia: 15.6;cerebral cortex: 36.1;hippocampal formation: 29.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CACO-2: 1.3;NTERA-2: 1.6;RPTEC TERT1: 1.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA069762 Approved NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 5: NTERA-2 - Transcription" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA069762: AB_2686192" "unprognostic (2.01e-2)" "unprognostic (4.07e-2)" "unprognostic (7.89e-2)" "unprognostic (3.77e-3)" "unprognostic (3.39e-3)" "unprognostic (9.36e-2)" "unprognostic (5.92e-2)" "unprognostic (1.77e-2)" "unprognostic (6.85e-2)" "unprognostic (2.24e-1)" "unprognostic (4.68e-2)" "unprognostic (4.12e-2)" "unprognostic (4.48e-5)" "unprognostic (2.43e-1)" "unprognostic (8.76e-2)" "unprognostic (1.63e-1)" "unprognostic (2.37e-1)" 0.2 0.0 11.5 0.0 15.6 0.0 0.0 0.0 36.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 29.4 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.5 15.6 0.0 36.1 29.4 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 15.3 0.0 0.0 0.0 0.0 0.0 8.8 0.7 0.5 3.1 0.0 0.0 0.0 0.0 0.0 0.0 2.6 1.9 0.0 35.0 0.3 0.1 0.4 0.0 0.0 625.2 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 882.5 0.5 0.0 0.0 0.0 35.8 0.0 0.0 0.0 14.0 0.0 0.1 0.0 173.4 9.9 0.0 0.1 0.4 0.0 0.2 0.0 0.1 0.0 1.8 0.0 0.1 0.2 1.0 3.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 GRIN2D "EB11, GluN2D, NMDAR2D, NR2D" ENSG00000105464 "Glutamate ionotropic receptor NMDA type subunit 2D" O15399 19 48393668-48444931 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins" "Ion transport, Transport" "Ion channel, Ligand-gated ion channel, Receptor" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "brain: 8.4" "Group enriched" "Detected in some" 5 "Inhibitory neurons: 36.5;Oligodendrocyte precursor cells: 15.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 17.3;EFO-21: 11.5;HMC-1: 28.4;NB-4: 17.6;SK-BR-3: 15.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" CAB009006 Approved NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 3: HMC-1 - Innate immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB009006: AB_2279191" "unprognostic (9.96e-2)" "unprognostic (6.98e-2)" "unprognostic (1.17e-1)" "unprognostic (5.08e-3)" "unprognostic (1.46e-1)" "unprognostic (4.17e-1)" "unprognostic (1.43e-4)" "unprognostic (7.84e-2)" "unprognostic (2.72e-1)" "unprognostic (2.23e-3)" "unprognostic (1.57e-1)" "unprognostic (1.80e-1)" "unprognostic (6.66e-13)" "unprognostic (2.15e-2)" "unprognostic (1.92e-2)" "unprognostic (1.26e-3)" "unprognostic (1.14e-1)" 0.6 0.3 3.0 0.3 1.4 0.1 0.3 3.0 2.8 0.1 0.0 0.2 0.5 0.1 0.0 0.1 0.4 0.3 0.3 1.2 4.8 0.1 0.1 0.2 0.1 4.7 5.8 0.2 0.1 0.9 0.2 0.9 4.8 0.3 0.0 0.8 0.2 0.0 0.1 0.6 0.7 0.1 2.4 0.2 0.2 1.1 8.4 0.0 0.7 0.0 0.0 0.1 0.3 0.6 1.5 17.3 0.4 0.0 1.2 3.5 9.8 2.1 0.0 0.5 0.1 1.3 10.0 0.5 11.5 1.1 0.1 0.1 0.1 0.2 0.3 2.3 0.4 5.4 0.6 2.2 1.8 0.4 28.4 1.3 0.0 1.0 0.0 0.1 0.4 0.1 9.9 0.5 0.1 3.2 0.0 17.6 0.5 8.6 0.3 0.1 0.0 0.3 0.3 0.0 1.8 1.7 0.8 15.0 0.1 0.2 0.0 6.6 5.8 0.0 0.1 0.0 0.0 5.8 3.5 0.0 0.0 2.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 1.4 3.0 2.8 1.2 4.8 4.7 5.8 4.8 2.4 8.4 0.6 0.3 0.0 0.0 1.6 0.0 0.0 0.1 0.0 0.0 2.9 0.0 0.3 2.6 0.0 0.0 0.0 0.0 0.9 0.0 0.1 0.0 0.1 0.9 0.2 0.3 0.4 0.0 0.0 2.3 0.2 4.6 0.9 0.0 0.1 0.0 0.1 1.8 0.2 1.3 0.0 36.5 0.0 0.0 0.3 0.2 1.5 0.6 0.6 0.0 1.0 0.2 0.7 0.0 15.6 1.3 0.4 0.0 0.4 0.0 0.1 0.0 0.0 0.0 1.9 0.0 0.0 0.5 0.2 0.4 0.0 0.0 1.8 0.2 0.2 0.1 0.0 GRK1 "GPRK1, RHOK, RK" ENSG00000185974 "G protein-coupled receptor kinase 1" Q15835 13 113667219-113737736 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Sensory transduction, Vision" "Kinase, Serine/threonine-protein kinase, Transferase" "Congenital stationary night blindness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 50 "retina: 42.6" "Group enriched" "Detected in some" 16 "Cone photoreceptor cells: 56.3;Rod photoreceptor cells: 84.9" "Cancer enriched" "Detected in single" 5 "thyroid cancer: 0.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA035200, HPA059376" Enhanced NA NA "Cluster 79: Retina - Phototransduction" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA035200: AB_2674515, HPA059376: AB_2683996" "unprognostic (7.93e-2)" "unprognostic (2.50e-1)" "unprognostic (1.87e-1)" "unprognostic (1.24e-5)" "unprognostic (1.76e-3)" "unprognostic (1.53e-1)" "unprognostic (3.59e-2)" "unprognostic (2.21e-2)" "unprognostic (1.84e-3)" "unprognostic (2.00e-2)" "unprognostic (4.02e-2)" "unprognostic (6.91e-2)" "unprognostic (6.18e-2)" "unprognostic (6.11e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 42.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.6 0.0 0.0 0.0 56.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 4.4 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 84.9 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GRM1 "GPRC1A, mGlu1, MGLUR1, PPP1R85" ENSG00000152822 "Glutamate metabotropic receptor 1" Q13255 6 146027646-146437601 "Disease related genes, G-protein coupled receptors, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters" "G-protein coupled receptor, Receptor, Transducer" "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "brain: 27.6" "Group enriched" "Detected in some" 6 "Excitatory neurons: 215.5;Inhibitory neurons: 138.8;Rod photoreceptor cells: 124.9" "Not detected" "Not detected" "Region enhanced" "Detected in many" "cerebellum: 27.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA015701 Approved Supported Approved Vesicles NA NA "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Vesicles "HPA015701: AB_1853917" "unprognostic (1.04e-2)" "unprognostic (7.33e-2)" "unprognostic (3.73e-3)" "unprognostic (9.77e-3)" "unprognostic (6.75e-2)" "unprognostic (2.13e-1)" "unprognostic (1.09e-1)" "unprognostic (5.78e-2)" "unprognostic (4.31e-2)" "unprognostic (2.93e-2)" "unprognostic (9.48e-3)" "unprognostic (7.92e-2)" "unprognostic (1.84e-2)" "unprognostic (1.03e-1)" "unprognostic (3.50e-2)" "unprognostic (8.33e-3)" "unprognostic (9.76e-2)" 0.0 0.0 3.3 0.0 3.6 0.0 0.0 27.6 6.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 2.8 7.3 2.3 0.7 0.0 0.0 0.0 0.0 3.1 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 5.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 7.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 3.6 27.6 6.8 7.3 2.3 0.0 3.1 0.9 0.0 7.7 0.0 0.0 0.0 0.0 23.5 0.0 0.0 0.0 0.0 0.0 13.8 0.0 0.0 3.7 0.0 0.0 1.8 16.7 0.0 0.0 0.0 1.9 0.0 8.5 0.1 0.0 0.2 0.0 0.0 215.5 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 0.0 0.6 6.7 138.8 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 3.7 0.0 4.0 0.0 8.0 8.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 124.9 0.0 0.0 0.1 1.1 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GRM6 "CSNB1B, GPRC1F, mGlu6, MGLUR6" ENSG00000113262 "Glutamate metabotropic receptor 6" O15303 5 178977587-178996206 "Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins" "Sensory transduction, Vision" "G-protein coupled receptor, Receptor, Transducer" "Congenital stationary night blindness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 57 "retina: 42.6" "Cell type enriched" "Detected in some" 31 "Bipolar cells: 440.5" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA014511 Enhanced NA NA "Cluster 79: Retina - Phototransduction" "Cluster 56: Bipolar cells - Visual perception" "HPA014511: AB_2669025" "unprognostic (1.85e-1)" "unprognostic (1.54e-1)" "unprognostic (8.41e-2)" "unprognostic (1.27e-1)" "unprognostic (4.16e-1)" "unprognostic (2.25e-3)" "unprognostic (7.72e-2)" "unprognostic (2.32e-2)" "unprognostic (2.12e-3)" "unprognostic (6.27e-2)" "unprognostic (3.34e-4)" "unprognostic (2.58e-1)" "unprognostic (3.36e-4)" "unprognostic (1.23e-1)" "unprognostic (6.45e-2)" "unprognostic (7.59e-3)" "unprognostic (1.97e-1)" 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.2 0.1 0.1 0.0 0.1 0.0 0.1 0.1 0.0 0.7 0.0 0.1 0.3 0.0 42.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.5 0.0 0.0 0.4 0.3 0.1 0.0 440.5 0.1 0.0 1.9 0.0 0.0 0.0 2.1 0.1 0.0 0.0 0.0 0.0 1.0 0.2 0.4 0.6 0.0 0.0 0.5 0.0 0.0 0.2 0.0 0.1 0.0 0.2 0.0 0.0 0.1 3.3 0.4 0.0 0.0 0.0 0.9 1.1 0.0 0.1 0.0 0.0 0.6 4.2 0.0 1.0 0.1 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 14.2 0.0 0.3 0.2 0.9 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.1 GRN "CLN11, PCDGF, PGRN" ENSG00000030582 "Granulin precursor" P28799 17 44345246-44353106 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" Cytokine "Neurodegeneration, Neuronal ceroid lipofuscinosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hofbauer cells: 1420.7;Kupffer cells: 892.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 6 "classical monocyte: 2057.5;intermediate monocyte: 1122.4;myeloid DC: 1534.2;neutrophil: 851.2;non-classical monocyte: 548.1;plasmacytoid DC: 1331.9" "Group enriched" "Detected in all" 9 "dendritic cells: 1534.2;granulocytes: 851.2;monocytes: 2057.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008763, CAB019394, HPA028747" Uncertain Enhanced Endosomes,Lysosomes "Secreted to blood" NA NA 138000000 110000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 18: U-2197 - ECM organization" "Cluster 4: Macrophages - Innate immune response" Lysosomes Endosomes "CAB019394: , HPA008763: AB_1850339, HPA028747: AB_10603767" "unprognostic (1.84e-1)" "unprognostic (2.34e-1)" "unprognostic (8.38e-3)" "unprognostic (2.82e-1)" "prognostic unfavorable (8.78e-4)" "unprognostic (7.41e-2)" "unprognostic (3.53e-3)" "unprognostic (3.57e-1)" "unprognostic (1.63e-1)" "unprognostic (2.40e-1)" "unprognostic (2.24e-2)" "unprognostic (1.52e-1)" "unprognostic (6.34e-2)" "unprognostic (2.54e-1)" "unprognostic (1.43e-1)" "unprognostic (1.43e-1)" "unprognostic (1.62e-1)" 158.9 123.2 61.5 160.4 67.2 478.5 120.7 67.7 97.3 156.7 73.9 189.8 130.9 108.3 134.0 534.0 87.1 157.3 153.0 61.0 69.7 167.4 118.9 309.5 183.2 81.0 71.5 73.8 108.9 87.8 84.4 183.2 87.6 111.7 110.3 12.5 262.9 100.6 60.6 189.7 179.0 91.9 71.8 349.8 127.9 59.4 94.3 67.8 127.7 45.9 107.8 150.0 198.3 97.3 119.3 197.5 52.7 159.5 443.2 231.8 181.2 147.3 447.5 231.6 309.8 86.3 294.0 364.0 299.4 217.6 312.9 185.3 68.6 334.5 75.8 55.8 186.8 38.4 93.8 175.2 245.5 61.6 493.6 332.4 450.5 188.1 106.0 391.2 269.8 64.3 75.1 51.3 148.8 183.1 32.8 172.8 44.3 110.5 334.0 97.7 180.8 433.0 248.2 145.9 54.7 74.7 201.0 92.7 360.9 138.0 209.4 229.0 340.7 437.6 104.6 300.5 97.8 116.3 313.9 122.3 268.1 149.6 124.2 215.1 2057.5 176.5 35.1 1122.4 27.8 174.0 37.1 31.1 1534.2 112.2 27.8 26.5 851.2 30.6 548.1 1331.9 55.4 1613.4 61.5 67.2 67.7 97.3 61.0 69.7 81.0 71.5 87.6 71.8 94.3 97.3 113.0 86.6 83.3 12.7 82.8 112.7 151.1 574.2 97.9 23.6 85.7 69.7 90.7 133.0 332.7 218.8 18.8 429.1 195.7 494.8 9.8 447.7 2.1 103.8 83.8 170.9 124.3 38.7 6.8 307.3 324.1 149.4 83.6 372.5 75.5 90.0 207.8 84.7 1420.7 47.1 6.6 214.6 146.5 892.0 360.8 6.8 60.9 699.2 208.1 20.6 501.6 58.9 20.6 11.1 11.8 285.3 581.7 57.2 65.8 70.7 312.1 120.5 70.0 11.8 85.5 45.4 83.3 25.1 72.2 255.5 96.5 640.0 30.8 89.6 274.5 175.6 GRXCR1 "DFNB25, PPP1R88" ENSG00000215203 "Glutaredoxin and cysteine rich domain containing 1" A8MXD5 4 42892713-43030658 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Hearing "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 6 "seminal vesicle: 2.5" "Group enriched" "Detected in some" 4 "Early spermatids: 3.2;Spermatocytes: 2.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA040824 Uncertain NA NA "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA040824: AB_10794863" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GRXCR2 DFNB101 ENSG00000204928 "Glutaredoxin and cysteine rich domain containing 2" A6NFK2 5 145858521-145937126 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Deafness, Non-syndromic deafness" "Evidence at transcript level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Evidence at transcript level" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "Early spermatids: 15.1;Late spermatids: 16.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "cerebral cortex: 1.2;hippocampal formation: 4.1" HPA059421 Uncertain NA NA "Cluster 34: Spermatids - Unknown function" "HPA059421: AB_2684010" "unprognostic (4.71e-2)" "unprognostic (2.91e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 16.8 0.6 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GSDME "DFNA5, ICERE-1" ENSG00000105928 "Gasdermin E" O60443 7 24698355-24757940 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters" Necrosis "Deafness, Non-syndromic deafness, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in some" "Cytotrophoblasts: 168.1;Distal tubular cells: 41.1;Extravillous trophoblasts: 26.5;Hofbauer cells: 39.9;Syncytiotrophoblasts: 104.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "memory B-cell: 9.0;myeloid DC: 5.9;naive B-cell: 8.4" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA011326, CAB019306" Approved Supported Cytosol NA NA "Cluster 37: B-cells - Transcription" "Cluster 57: Non-specific - Angiogenesis" "Cluster 30: Epithelial cell lines - Translation" "Cluster 47: Cytotrophoblasts - Unknown function" Cytosol "CAB019306: , HPA011326: AB_1847629" "unprognostic (1.08e-1)" "unprognostic (1.77e-2)" "unprognostic (6.29e-2)" "unprognostic (6.36e-3)" "unprognostic (6.70e-2)" "unprognostic (1.49e-2)" "prognostic unfavorable (2.49e-5)" "unprognostic (4.35e-2)" "unprognostic (1.34e-1)" "unprognostic (1.35e-1)" "unprognostic (2.23e-1)" "unprognostic (1.24e-1)" "unprognostic (1.13e-3)" "unprognostic (1.48e-3)" "unprognostic (6.70e-2)" "unprognostic (1.06e-1)" "unprognostic (5.90e-2)" 13.5 7.8 16.4 2.9 16.7 0.5 7.6 13.3 18.0 17.3 9.2 6.4 7.7 24.8 15.3 3.6 14.3 8.5 9.7 18.1 15.0 13.3 4.5 4.4 5.8 19.4 18.7 16.9 2.6 7.3 7.0 35.0 16.1 7.5 2.4 6.3 3.1 21.1 7.8 3.0 26.8 15.1 16.5 1.8 3.9 12.9 14.1 5.8 14.5 5.2 3.8 15.0 10.1 26.6 31.4 21.7 9.6 41.2 51.4 28.6 16.4 24.1 63.6 24.5 34.3 22.9 1.1 0.5 20.6 66.4 81.7 20.5 5.8 105.4 42.8 0.1 2.1 0.8 39.3 48.0 43.0 0.1 1.5 31.3 75.3 43.5 103.1 73.0 42.3 13.8 3.0 5.2 55.3 0.4 1.9 0.8 10.2 0.1 15.7 0.2 33.6 0.0 74.5 21.9 0.4 60.0 36.5 0.6 42.3 24.3 2.2 2.8 27.9 23.1 39.7 31.6 29.2 2.4 0.6 15.5 69.8 0.1 5.8 0.0 1.9 0.0 0.0 0.2 0.0 9.0 0.1 0.0 5.9 8.4 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.6 16.4 16.7 13.3 18.0 18.1 15.0 19.4 18.7 16.1 16.5 14.1 26.6 1.0 6.4 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 2.1 3.9 0.0 0.0 0.6 5.5 0.0 168.1 0.0 0.0 41.1 1.9 0.0 0.7 16.9 1.3 0.0 0.0 0.0 0.9 26.5 4.3 0.0 1.0 0.0 4.8 0.0 0.0 39.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.7 0.0 0.0 8.3 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.1 0.0 0.0 8.8 1.5 0.0 0.0 0.0 4.8 0.0 0.0 0.0 0.0 104.7 0.7 0.9 0.0 0.0 GSN DKFZp313L0718 ENSG00000148180 Gelsolin P06396 9 121207794-121332843 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Cilium biogenesis/degradation" "Actin capping, Actin-binding" "Amyloidosis, Cancer-related genes, Corneal dystrophy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 2486.9" "Cell type enhanced" "Detected in all" "Adipocytes: 1649.5;Fibroblasts: 4145.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 1135.9" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC diff: 1313.9;HaCaT: 533.6" "Region enriched" "Detected in all" 4 "white matter: 869.2" "Low region specificity" "Detected in all" "CAB010823, CAB016728, CAB036009, HPA054026" Supported Supported "Actin filaments" "Secreted to blood" NA NA 112000000000 240000000000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 46: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Actin filaments" "CAB010823: , CAB016728: , CAB036009: , HPA054026: AB_2682347" "unprognostic (3.25e-2)" "unprognostic (4.44e-3)" "unprognostic (1.22e-1)" "unprognostic (3.10e-3)" "unprognostic (4.23e-2)" "unprognostic (4.85e-2)" "unprognostic (1.21e-1)" "unprognostic (1.49e-1)" "unprognostic (1.22e-1)" "unprognostic (1.20e-1)" "unprognostic (6.54e-2)" "unprognostic (6.56e-2)" "unprognostic (3.06e-2)" "unprognostic (8.01e-3)" "unprognostic (4.98e-2)" "unprognostic (1.23e-2)" "prognostic unfavorable (1.79e-5)" 1892.9 162.5 169.7 109.7 317.4 175.0 1244.6 291.2 213.0 577.4 155.6 867.4 152.0 767.7 108.2 435.1 663.2 226.1 2486.9 163.4 219.8 153.1 40.6 308.7 93.2 380.9 284.6 303.8 140.7 70.9 260.6 79.0 354.7 344.0 204.6 57.8 508.7 400.9 420.4 612.9 384.1 350.0 270.6 136.5 469.7 78.1 279.0 99.7 702.6 687.8 87.3 897.2 655.5 376.1 38.4 60.9 39.0 129.8 1313.9 351.8 26.4 130.9 264.7 30.1 56.5 64.2 130.1 3.0 36.6 182.8 48.5 533.6 3.2 84.3 16.9 6.5 7.6 31.2 57.1 167.5 32.0 7.0 146.0 140.0 84.9 51.7 34.4 83.1 120.4 6.1 10.4 5.3 137.0 81.1 0.4 304.4 12.7 76.2 45.1 8.4 13.1 4.3 156.4 63.4 7.7 10.4 60.9 62.5 197.2 84.6 245.3 158.8 217.4 100.0 33.2 10.4 12.8 1.8 2.0 3.2 105.3 18.2 278.1 302.9 122.0 1135.9 1.9 84.9 0.8 17.6 0.8 1.4 345.3 6.7 0.8 0.7 307.1 217.8 23.7 243.2 4.2 105.4 169.7 317.4 291.2 213.0 163.4 219.8 380.9 284.6 354.7 270.6 279.0 376.1 1649.5 147.4 55.7 82.3 22.7 341.2 278.1 252.7 103.0 7.5 120.8 212.0 272.0 85.8 354.3 121.4 77.2 55.8 74.9 557.7 105.7 258.5 9.9 141.9 163.1 724.8 63.1 17.2 17.1 202.3 94.3 4145.2 322.7 220.6 104.0 31.8 273.5 16.5 492.6 1.7 9.0 762.9 512.7 139.0 798.7 20.2 588.7 273.7 537.2 155.5 487.5 220.6 55.6 33.2 443.1 315.8 590.5 671.8 24.1 91.4 77.4 39.8 583.7 86.5 611.4 362.4 740.4 8.7 13.7 175.9 299.1 84.0 58.7 34.3 52.2 144.7 GTPBP2 ENSG00000172432 "GTP binding protein 2" Q9BX10 6 43605316-43629264 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 47.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 5.4" "Lineage enriched" "Detected in many" 4 "granulocytes: 5.4" "Cell line enhanced" "Detected in all" "hTERT-HME1: 181.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031418, HPA031419" Approved Approved Vesicles NA Yes "Cluster 34: Basophils - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 51: Myeloid cells - Hemostasis" Vesicles "HPA031418: AB_2673872, HPA031419: AB_10600709" "unprognostic (1.35e-1)" "unprognostic (1.01e-1)" "unprognostic (8.94e-2)" "unprognostic (1.08e-3)" "unprognostic (2.56e-1)" "unprognostic (1.37e-1)" "prognostic unfavorable (1.08e-6)" "unprognostic (4.71e-2)" "unprognostic (2.58e-3)" "unprognostic (6.47e-2)" "unprognostic (8.31e-2)" "unprognostic (6.15e-3)" "prognostic unfavorable (1.44e-15)" "unprognostic (1.13e-1)" "unprognostic (3.36e-1)" "unprognostic (1.06e-1)" "unprognostic (2.89e-3)" 38.5 29.8 14.5 15.3 15.3 28.7 37.4 16.5 17.9 39.5 16.0 34.0 19.9 26.8 15.5 61.3 25.1 12.5 35.4 14.4 15.0 36.1 33.3 46.7 16.9 17.5 16.7 29.0 40.0 24.1 40.0 18.0 15.6 31.5 17.0 18.9 42.6 11.6 31.6 26.5 34.7 15.4 14.3 44.5 35.9 27.2 17.0 16.8 44.2 10.4 17.0 33.9 40.4 16.2 59.2 10.9 37.7 24.0 28.3 30.6 45.6 56.3 55.2 52.6 70.1 12.0 19.9 18.8 23.5 26.9 53.8 31.6 9.8 14.5 45.6 60.9 31.6 44.1 33.0 13.9 126.0 35.6 50.1 35.1 160.5 72.5 181.4 35.1 20.5 25.7 77.1 107.8 26.2 13.9 23.4 45.1 10.6 41.2 14.8 19.4 29.5 17.5 24.0 25.8 33.1 32.4 19.5 14.0 72.5 19.0 30.3 37.3 34.8 27.2 33.2 20.5 38.3 70.8 38.2 26.7 45.4 26.0 27.5 5.4 0.8 2.1 1.2 0.7 0.9 0.6 0.2 1.1 0.4 1.0 0.7 1.0 1.3 0.6 0.9 1.1 0.6 1.2 14.5 15.3 16.5 17.9 14.4 15.0 17.5 16.7 15.6 14.3 17.0 16.2 19.6 3.2 5.5 6.8 5.1 5.2 2.3 4.3 1.2 5.9 7.5 5.0 11.4 5.7 5.7 1.8 8.4 2.8 5.3 24.0 0.0 10.1 17.0 8.5 8.2 9.7 1.2 14.3 7.2 10.1 9.8 6.8 11.7 13.3 1.3 5.7 6.8 5.5 8.2 1.7 6.3 8.8 2.0 12.6 6.5 47.6 5.3 16.0 7.2 5.6 10.1 3.4 1.0 5.5 9.1 20.7 13.4 4.1 2.4 5.8 6.8 1.8 4.1 9.2 13.1 5.3 7.8 7.1 8.1 4.4 5.3 2.5 3.8 4.7 6.0 12.6 GUCA1A "C6orf131, COD3, CORD14, dJ139D8.6, GCAP, GCAP1, GUCA, GUCA1" ENSG00000048545 "Guanylate cyclase activator 1A" P43080 6 42155406-42181338 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Sensory transduction, Vision" "Cone-rod dystrophy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 91 "retina: 804.8" "Cell type enhanced" "Detected in some" "Cone photoreceptor cells: 667.2;Late spermatids: 432.4;Muller glia cells: 219.9;Rod photoreceptor cells: 1191.6" "Cancer enriched" "Detected in single" 9 "testis cancer: 3.5" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 10 "plasmacytoid DC: 4.9" "Lineage enriched" "Detected in single" 10 "dendritic cells: 4.9" "Group enriched" "Detected in some" 8 "NTERA-2: 3.8;SH-SY5Y: 4.5" "Low region specificity" "Detected in single" "Not detected" "Not detected" "HPA005561, HPA075056" Enhanced Approved "Plasma membrane" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 79: Retina - Phototransduction" "Cluster 5: NTERA-2 - Transcription" "Cluster 46: Photoreceptor cells - Phototransduction" "Plasma membrane" "HPA005561: AB_2667361, HPA075056: " "unprognostic (1.91e-2)" "unprognostic (3.92e-3)" "unprognostic (2.49e-2)" "unprognostic (9.16e-2)" "unprognostic (1.04e-4)" "unprognostic (9.70e-2)" "unprognostic (6.71e-3)" "unprognostic (1.89e-1)" "unprognostic (1.59e-2)" "unprognostic (3.08e-3)" "unprognostic (2.79e-1)" "unprognostic (1.51e-1)" "unprognostic (1.54e-1)" "unprognostic (1.16e-1)" 0.0 0.0 1.5 0.1 3.5 0.1 0.0 0.9 1.8 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 5.4 0.0 0.0 0.0 0.1 1.5 1.4 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 804.8 0.0 0.0 0.1 0.1 0.1 0.1 0.8 0.0 0.0 8.8 6.2 0.0 0.0 0.0 0.2 0.0 0.1 1.2 0.0 0.0 0.5 0.0 0.1 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 3.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.5 0.0 0.1 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.2 0.1 0.5 0.0 0.0 4.9 0.0 0.0 1.5 3.5 0.9 1.8 1.3 5.4 1.5 1.4 1.4 0.8 6.2 1.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 140.7 0.0 0.0 0.3 0.0 0.0 0.0 667.2 0.6 1.3 0.0 0.0 0.0 106.5 0.0 0.0 8.2 0.0 0.0 0.3 0.0 0.3 0.9 0.0 0.0 0.0 0.5 0.0 0.0 0.2 65.6 1.0 0.0 4.1 0.0 0.0 432.4 1.8 0.1 0.0 0.0 5.2 219.9 0.0 0.0 0.1 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.1 1191.6 0.0 0.0 1.2 3.2 3.9 0.0 0.0 0.3 0.0 0.1 0.0 0.1 GUCA1B "GCAP2, RP48" ENSG00000112599 "Guanylate cyclase activator 1B" Q9UMX6 6 42183284-42194956 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters" "Sensory transduction, Vision" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 99 "retina: 466.0" "Group enriched" "Detected in some" 4 "Astrocytes: 23.2;Cone photoreceptor cells: 83.4;Oligodendrocytes: 28.2;Rod photoreceptor cells: 53.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "hTCEpi: 4.3;U-698: 3.9" "Low region specificity" "Detected in single" "Not detected" "Not detected" HPA055479 Enhanced NA NA "Cluster 79: Retina - Phototransduction" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 9: Photoreceptor cells - Phototransduction" "HPA055479: AB_2732598" "unprognostic (1.61e-1)" "unprognostic (3.28e-1)" "unprognostic (1.14e-6)" "unprognostic (5.39e-2)" "unprognostic (1.73e-2)" "unprognostic (2.87e-3)" "unprognostic (6.06e-3)" "unprognostic (1.12e-1)" "unprognostic (1.34e-1)" "unprognostic (5.57e-1)" "unprognostic (1.66e-1)" "unprognostic (1.72e-2)" "unprognostic (3.28e-7)" "unprognostic (4.50e-2)" "unprognostic (2.20e-1)" "unprognostic (1.76e-2)" "unprognostic (2.59e-3)" 1.5 0.9 3.5 0.8 3.6 1.3 1.4 3.8 4.1 2.3 2.2 1.3 0.3 1.9 1.0 0.8 2.3 0.2 1.6 3.2 3.2 1.0 1.9 1.1 0.7 3.3 3.2 2.7 0.9 0.2 1.0 0.4 3.6 1.5 0.5 466.0 1.1 0.5 2.6 2.8 1.4 1.0 3.0 2.1 0.8 2.6 3.5 1.0 1.0 0.9 0.9 1.1 1.4 4.6 0.1 0.6 1.3 0.5 1.0 0.9 0.3 0.5 0.8 0.8 0.7 1.1 0.4 1.6 0.8 0.1 0.2 0.4 1.4 0.2 1.4 1.3 0.6 0.4 0.1 0.2 0.4 1.5 0.5 0.3 4.3 0.8 1.1 0.4 0.1 1.2 1.0 1.5 0.2 1.3 0.6 1.0 0.0 0.3 0.3 0.2 0.8 0.1 0.8 0.5 0.6 0.9 0.0 0.2 0.1 0.2 0.1 0.9 0.0 0.2 1.7 0.6 0.7 2.7 1.3 3.9 0.2 0.6 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.2 0.0 3.5 3.6 3.8 4.1 3.2 3.2 3.3 3.2 3.6 3.0 3.5 4.6 0.2 0.0 0.0 23.2 0.0 0.3 0.1 0.0 0.0 4.0 0.2 0.1 0.3 0.0 0.0 0.0 83.4 0.1 0.1 0.1 0.0 0.0 0.1 0.3 0.3 0.3 0.0 0.0 8.1 0.0 0.0 0.2 0.0 0.1 0.0 0.2 0.0 0.0 0.0 6.7 11.2 0.0 0.0 0.0 0.0 0.1 0.0 0.1 1.8 2.8 0.1 8.1 0.0 11.6 28.2 0.1 0.0 0.0 0.0 0.3 0.0 0.1 0.0 53.0 0.0 0.5 0.4 0.5 0.3 0.0 0.1 0.0 0.2 0.0 0.0 0.2 GUCY2D "CORD6, CYGD, GUC1A4, GUC2D, LCA, LCA1, retGC, RETGC-1, ROS-GC1" ENSG00000132518 "Guanylate cyclase 2D, retinal" Q02846 17 8002615-8020342 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "cGMP biosynthesis, Sensory transduction, Vision" Lyase "Cone-rod dystrophy, Congenital stationary night blindness, Disease variant, Leber congenital amaurosis" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 24 "retina: 34.2" "Group enriched" "Detected in some" 4 "Cone photoreceptor cells: 62.6;Rod photoreceptor cells: 58.3" "Low cancer specificity" "Detected in single" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 31 "plasmacytoid DC: 8.0" "Lineage enriched" "Detected in single" 50 "dendritic cells: 8.0" "Cell line enriched" "Detected in some" 5 "JURKAT: 5.9" "Low region specificity" "Detected in many" "Low region specificity" "Detected in single" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 79: Retina - Phototransduction" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 9: Photoreceptor cells - Phototransduction" "unprognostic (3.57e-4)" "unprognostic (5.05e-1)" "unprognostic (1.49e-1)" "unprognostic (9.75e-5)" "unprognostic (5.94e-2)" "unprognostic (1.86e-1)" "unprognostic (4.44e-2)" "unprognostic (3.81e-2)" "unprognostic (2.92e-1)" "unprognostic (2.26e-1)" "unprognostic (7.54e-2)" "unprognostic (4.44e-1)" "unprognostic (7.59e-5)" "unprognostic (1.05e-1)" "unprognostic (3.46e-1)" "unprognostic (3.08e-1)" "unprognostic (1.07e-1)" 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 34.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.4 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.3 0.1 0.0 0.0 0.0 0.0 0.0 5.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 8.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.1 0.4 1.3 5.2 5.7 2.1 1.4 3.8 1.9 0.0 1.4 0.0 62.6 1.2 2.7 0.0 1.9 0.1 6.9 0.2 0.1 0.1 0.0 0.0 0.5 0.0 0.7 0.1 0.0 0.6 0.0 0.1 0.0 1.2 1.1 0.0 0.4 0.0 0.0 0.6 0.0 14.9 0.0 0.6 0.0 0.0 0.8 6.1 0.0 0.0 0.1 0.1 0.0 0.4 0.0 1.1 0.0 0.4 0.1 58.3 0.0 0.0 0.0 0.4 0.1 2.4 0.3 2.2 0.1 0.0 0.2 0.5 GUF1 FLJ13220 ENSG00000151806 "GUF1 homolog, GTPase" Q8N442 4 44678420-44700928 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Protein biosynthesis" Hydrolase "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003934, HPA024222" Approved Approved Nucleoplasm,Mitochondria NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Mitochondria" "HPA003934: AB_1079034, HPA024222: AB_2671488" "unprognostic (1.32e-2)" "unprognostic (1.55e-1)" "unprognostic (1.66e-2)" "unprognostic (3.65e-3)" "unprognostic (7.56e-2)" "unprognostic (1.37e-1)" "unprognostic (5.59e-2)" "unprognostic (2.60e-1)" "unprognostic (1.37e-2)" "unprognostic (3.03e-2)" "unprognostic (1.56e-3)" "unprognostic (7.38e-3)" "prognostic favorable (2.66e-6)" "unprognostic (4.98e-3)" "unprognostic (1.74e-1)" "prognostic unfavorable (1.65e-5)" "unprognostic (5.40e-2)" 5.2 4.1 2.5 3.9 3.2 6.3 5.2 4.3 3.6 3.5 0.6 5.7 4.6 4.8 3.8 5.2 4.1 2.7 6.1 3.3 2.5 6.9 7.1 3.1 4.7 1.6 1.9 4.9 3.7 4.3 2.4 3.7 1.9 4.9 5.9 6.7 4.0 3.5 15.8 5.0 6.3 3.5 2.4 4.8 7.9 5.9 2.2 4.4 5.3 17.0 4.6 3.9 3.8 4.4 11.9 6.0 10.9 13.9 4.4 9.0 24.0 16.1 8.2 16.2 12.4 10.5 8.3 25.8 12.3 7.7 14.9 9.2 18.7 18.2 18.2 8.7 12.2 30.7 5.3 7.2 14.3 33.4 12.7 9.2 8.1 12.1 10.5 7.6 11.8 15.0 31.7 4.9 13.2 5.9 19.1 7.0 7.0 8.5 13.8 13.5 22.5 11.0 4.8 4.6 14.8 11.1 10.1 4.2 11.2 8.4 6.8 9.6 11.7 11.0 12.7 14.8 19.1 17.9 17.4 18.3 11.9 19.7 9.6 0.5 2.2 2.3 2.0 2.9 2.6 2.1 2.1 1.8 2.1 1.7 1.9 2.0 0.0 2.3 1.9 2.3 3.6 1.9 2.5 3.2 4.3 3.6 3.3 2.5 1.6 1.9 1.9 2.4 2.2 4.4 7.2 6.4 9.5 9.8 11.6 4.0 9.6 6.0 5.2 10.5 9.8 7.5 22.8 7.2 9.1 7.3 2.1 13.1 10.1 11.5 13.7 10.3 2.0 12.0 14.3 8.1 11.4 14.9 20.3 10.2 17.6 9.7 18.3 8.8 1.3 16.6 7.9 13.9 12.1 11.8 19.5 12.4 4.1 11.7 5.4 2.9 5.6 9.0 7.2 9.4 9.2 9.2 14.4 18.6 19.0 16.4 6.6 7.2 13.9 9.8 11.3 12.2 16.7 10.3 0.0 6.8 10.0 12.3 14.6 14.9 7.1 13.4 9.5 18.9 13.3 10.6 HACE1 KIAA1320 ENSG00000085382 "HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1" Q8IYU2 6 104728094-104859919 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Transcription, Transcription regulation, Ubl conjugation pathway" Transferase "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 30.6" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 45.9;Excitatory neurons: 118.8;Inhibitory neurons: 84.2;Microglial cells: 45.9;Oligodendrocyte precursor cells: 64.3;Oligodendrocytes: 74.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046071 Supported "Nuclear bodies,Endoplasmic reticulum" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 28: Placenta - Pregnancy" "Cluster 28: BEWO - Transcription regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Endoplasmic reticulum" "Nuclear bodies" "HPA046071: AB_2679524" "unprognostic (6.32e-2)" "unprognostic (3.77e-2)" "unprognostic (2.93e-2)" "unprognostic (1.12e-2)" "unprognostic (3.75e-2)" "unprognostic (3.75e-3)" "unprognostic (1.22e-3)" "unprognostic (4.63e-2)" "unprognostic (7.41e-2)" "unprognostic (1.24e-1)" "unprognostic (1.56e-2)" "unprognostic (2.25e-1)" "prognostic unfavorable (1.17e-5)" "unprognostic (1.12e-2)" "unprognostic (2.06e-1)" "prognostic unfavorable (7.50e-4)" "unprognostic (1.75e-1)" 3.7 3.2 2.7 2.2 4.4 2.9 3.1 5.0 4.8 3.9 0.4 2.6 2.1 3.9 1.1 5.3 3.3 3.1 3.3 3.1 2.5 6.2 1.6 3.6 2.2 1.9 2.6 3.8 1.9 7.2 1.5 30.6 2.3 3.7 1.8 11.5 2.9 4.1 2.2 2.5 2.1 4.0 1.4 2.5 2.4 10.4 3.1 3.9 4.5 4.1 2.4 3.3 2.9 5.8 3.9 2.7 11.3 14.3 6.6 8.8 13.3 7.7 11.9 4.8 7.2 2.5 2.3 2.2 3.4 5.9 8.1 2.6 2.8 5.3 10.0 9.1 7.2 7.7 2.5 3.4 6.6 6.8 2.5 5.9 4.7 6.2 5.2 6.3 8.0 9.2 7.6 2.4 9.6 2.8 5.1 4.1 5.0 2.9 2.6 8.0 12.8 0.9 3.8 6.6 6.1 9.1 4.2 4.3 2.3 7.3 2.7 9.2 8.5 3.9 3.2 10.5 7.4 3.5 4.1 7.6 4.0 6.4 7.1 0.0 0.6 0.7 1.2 1.0 1.3 0.9 1.1 1.1 0.6 0.8 1.2 0.9 0.1 0.8 0.5 0.8 0.4 0.5 2.7 4.4 5.0 4.8 3.1 2.5 1.9 2.6 2.3 1.4 3.1 5.8 11.6 3.2 1.1 42.4 5.1 4.7 2.3 2.3 5.2 11.6 5.3 3.7 6.7 1.5 3.9 5.5 45.9 10.6 4.1 1.5 1.9 1.6 6.2 2.7 6.2 12.9 1.8 3.0 118.8 1.5 5.4 7.1 5.6 3.4 1.3 7.1 4.2 2.6 5.7 16.8 84.2 2.0 0.0 4.1 2.4 4.6 6.2 3.5 1.8 45.9 4.3 6.1 8.2 64.3 74.6 1.4 2.9 3.8 3.7 1.6 3.8 5.7 2.6 31.7 6.6 6.4 6.6 13.2 3.5 5.3 4.7 6.3 6.2 2.9 1.9 1.9 HARS1 "HARS, HisRS, USH3B" ENSG00000170445 "Histidyl-tRNA synthetase 1" P12081 5 140673035-140691537 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Protein biosynthesis" "Aminoacyl-tRNA synthetase, Ligase" "Charcot-Marie-Tooth disease, Deafness, Disease variant, Neurodegeneration, Neuropathy, Retinitis pigmentosa, Usher syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Cytotrophoblasts: 41.4;dendritic cells: 11.5;Extravillous trophoblasts: 48.6;Hofbauer cells: 35.7;Syncytiotrophoblasts: 36.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036539 Approved Enhanced Cytosol NA NA 190000 "Cluster 27: Non-specific - Gene expression" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 39: CACO-2 - Unknown function" "Cluster 24: Non-specific - Transcription regulation" Cytosol "HPA036539: AB_10669796" "unprognostic (9.35e-2)" "unprognostic (9.95e-2)" "unprognostic (1.62e-3)" "unprognostic (1.65e-2)" "unprognostic (2.33e-1)" "unprognostic (8.57e-2)" "prognostic unfavorable (1.96e-7)" "unprognostic (6.50e-2)" "unprognostic (1.46e-1)" "unprognostic (3.82e-2)" "unprognostic (1.28e-2)" "unprognostic (2.40e-1)" "unprognostic (3.46e-2)" "unprognostic (2.99e-1)" "unprognostic (1.25e-1)" "unprognostic (6.26e-2)" "unprognostic (1.36e-1)" 31.6 39.9 64.8 27.1 67.0 24.3 29.3 64.9 88.7 32.9 57.9 39.2 21.8 34.5 27.1 42.9 30.8 21.0 38.3 67.8 72.2 30.7 47.3 27.2 29.6 71.2 69.9 31.3 40.8 37.1 60.0 18.5 72.8 33.0 29.6 18.5 29.2 32.0 56.7 53.9 28.6 35.2 62.1 32.2 36.0 25.6 77.4 32.2 27.1 33.4 36.8 34.3 32.0 71.9 66.8 94.3 55.5 120.5 68.9 74.9 57.9 104.8 75.0 118.6 109.4 174.8 54.1 88.4 90.3 118.3 94.3 66.6 85.9 169.2 111.6 74.5 105.0 63.7 115.4 111.8 86.3 101.1 49.8 80.4 51.5 129.0 72.6 69.5 122.1 52.2 56.5 68.6 125.6 111.0 71.8 100.6 43.3 52.3 60.9 65.4 82.0 70.9 97.0 82.2 86.5 83.7 86.1 121.5 84.2 54.9 89.5 55.5 100.3 107.8 41.6 61.5 144.7 68.5 90.5 89.4 82.8 83.1 76.1 16.2 31.2 24.0 61.0 46.3 54.2 34.9 54.1 57.6 48.5 34.6 58.1 55.4 8.1 59.3 54.9 34.3 51.3 56.7 64.8 67.0 64.9 88.7 67.8 72.2 71.2 69.9 72.8 62.1 77.4 71.9 9.6 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.0 0.0 0.0 0.0 0.0 41.4 11.5 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 48.6 6.1 0.0 0.0 0.0 0.0 0.0 0.0 35.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 36.0 1.7 0.0 0.0 0.0 HCN1 "BCNG-1, BCNG1, HAC-2" ENSG00000164588 "Hyperpolarization activated cyclic nucleotide gated potassium channel 1" O60741 5 45254948-45696498 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Sodium transport, Transport" "Ion channel, Ligand-gated ion channel, Potassium channel, Sodium channel, Voltage-gated channel" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 13 "brain: 7.2;retina: 17.6" "Group enriched" "Detected in some" 4 "Excitatory neurons: 671.7;Inhibitory neurons: 766.5;Rod photoreceptor cells: 199.4" "Not detected" "Not detected" "Region enhanced" "Detected in many" "cerebral cortex: 7.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "WM-115: 1.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019195 Enhanced NA NA "Cluster 58: Brain - Synaptic function" "Cluster 17: WM-115 - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA019195: AB_2670094" "unprognostic (1.30e-1)" "unprognostic (3.62e-1)" "unprognostic (1.64e-1)" "unprognostic (9.24e-3)" "unprognostic (6.82e-2)" "unprognostic (1.10e-1)" "unprognostic (9.63e-3)" "unprognostic (4.11e-3)" "unprognostic (6.78e-2)" "unprognostic (1.16e-2)" "unprognostic (7.42e-2)" "unprognostic (3.68e-3)" 0.0 0.4 1.8 0.0 2.5 0.1 0.0 2.4 7.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 2.5 1.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.3 0.0 0.0 0.0 0.0 17.6 0.0 0.0 0.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 2.5 2.4 7.2 2.5 1.0 0.1 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 24.5 0.0 0.1 0.1 0.0 0.0 29.4 0.0 0.0 7.4 0.0 0.0 0.0 133.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.9 0.0 0.0 671.7 0.7 0.0 0.6 0.0 0.1 0.0 0.6 0.0 0.0 0.0 6.7 766.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 51.5 0.0 14.8 0.0 21.1 14.4 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.0 199.4 0.0 0.3 0.1 0.6 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.3 HCRT "OX, PPOX" ENSG00000161610 "Hypocretin neuropeptide precursor" O43612 17 42184060-42185452 "Disease related genes, Human disease related genes, Predicted secreted proteins" Neuropeptide "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 1067 "brain: 384.8" "Cell type enhanced" "Detected in some" "Collecting duct cells: 1.8;Enteroendocrine cells: 3.0;Kupffer cells: 1.6;Oligodendrocyte precursor cells: 2.0;Proximal enterocytes: 1.6" "Cancer enhanced" "Detected in single" "glioma: 0.5" "Region enriched" "Detected in many" 7 "hypothalamus: 384.8" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in some" 5 "hypothalamus: 93.5" "Region enriched" "Detected in some" 21 "hypothalamus: 25.3" "HPA064801, CAB079778" Enhanced Supported "Secreted to blood" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 58: T-cells - T-cell receptor" "CAB079778: , HPA064801: " "unprognostic (3.34e-2)" "unprognostic (7.76e-5)" "unprognostic (3.21e-2)" "unprognostic (3.01e-2)" "unprognostic (2.20e-2)" "unprognostic (1.41e-1)" "unprognostic (1.23e-1)" 0.1 0.0 1.8 0.1 1.9 0.1 0.0 0.6 1.2 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 384.8 0.0 0.0 0.0 0.0 0.6 3.1 0.0 0.0 0.0 0.1 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 52.6 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.2 0.0 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.2 0.1 0.5 0.3 0.2 0.3 0.1 0.6 0.3 0.3 0.0 0.1 0.0 0.0 0.1 0.0 1.8 1.9 0.6 1.2 0.5 384.8 0.6 3.1 1.7 0.3 52.6 0.6 0.5 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.2 0.2 0.1 0.3 0.0 0.0 1.8 0.0 0.0 1.2 0.3 0.0 0.0 0.0 0.5 0.1 0.1 3.0 0.0 0.3 0.0 0.0 0.4 0.0 0.0 0.0 0.1 0.7 0.2 0.6 0.0 0.4 0.8 0.0 1.6 1.0 0.2 0.0 0.3 0.0 1.0 0.8 0.1 0.0 2.0 0.3 0.4 0.1 0.0 0.4 0.0 1.6 0.6 0.0 0.5 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.1 0.9 0.1 0.9 0.1 HEPACAM "FLJ25530, GLIALCAM" ENSG00000165478 "Hepatic and glial cell adhesion molecule" Q14CZ8 11 124919205-124936412 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Cell adhesion, Cell cycle, Growth arrest, Growth regulation" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 9 "brain: 222.6;choroid plexus: 79.7" "Group enriched" "Detected in some" 9 "Astrocytes: 184.8;Oligodendrocyte precursor cells: 72.9;Oligodendrocytes: 163.2" "Cancer enriched" "Detected in some" 12 "glioma: 29.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 30 "Hep G2: 25.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017613, CAB025486" Enhanced Approved Vesicles NA NA "Cluster 42: Non-specific - Transcription" "Cluster 70: Brain - Nervous system development" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 64: Astrocytes - Nervous system maintenance" Vesicles "CAB025486: , HPA017613: AB_1850595" "unprognostic (3.22e-3)" "unprognostic (1.06e-2)" "unprognostic (1.64e-1)" "unprognostic (6.41e-2)" "unprognostic (1.47e-1)" "unprognostic (9.16e-2)" "unprognostic (2.25e-1)" "unprognostic (7.58e-2)" "unprognostic (1.33e-2)" "unprognostic (1.06e-6)" "unprognostic (2.62e-1)" "unprognostic (3.21e-1)" 15.6 0.3 172.8 0.2 203.3 0.0 2.5 170.4 162.1 0.2 79.7 0.4 0.1 0.1 0.1 0.1 0.0 0.1 0.2 163.2 156.1 0.1 16.2 0.0 0.2 222.6 182.8 0.0 0.0 0.0 0.8 0.0 183.6 0.2 0.2 1.8 0.2 0.5 0.1 0.0 0.2 0.1 205.7 0.0 0.1 0.2 182.0 0.0 0.0 0.3 0.6 0.0 0.1 212.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 25.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.6 0.1 0.1 0.1 0.1 0.2 0.2 0.1 0.1 0.1 0.1 0.2 0.1 0.2 0.2 0.2 0.1 0.1 0.2 172.8 203.3 170.4 162.1 163.2 156.1 222.6 182.8 183.6 205.7 182.0 212.2 0.1 0.0 0.0 184.8 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.5 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 11.2 0.0 0.0 2.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 5.6 0.0 15.5 0.0 72.9 163.2 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 1.0 0.0 0.0 0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 HGF "DFNB39, F-TCF, HGFB, HPTA, SF" ENSG00000019991 "Hepatocyte growth factor" P14210 7 81699010-81770438 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins, RAS pathway related proteins" "Growth factor, Serine protease homolog" "Cancer-related genes, Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 10 "placenta: 311.9" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 23.8;Fibroblasts: 95.8;Hepatic stellate cells: 25.0;Muller glia cells: 36.2;Smooth muscle cells: 26.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "basophil: 94.0" "Lineage enriched" "Detected in many" 5 "granulocytes: 94.0" "Cell line enhanced" "Detected in some" "ASC TERT1: 171.6;HHSteC: 135.8;HL-60: 82.4;hTEC/SVTERT24-B: 87.4;Karpas-707: 240.7;U-87 MG: 62.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "CAB010333, HPA040360, HPA044088" Approved "Secreted to blood" NA NA 4110000 14000 "Cluster 10: Basophils - Unknown function" "Cluster 28: Placenta - Pregnancy" "Cluster 2: Karpas-707 - Immune response" "Cluster 33: Fibroblasts - ECM organization" "CAB010333: AB_647965, HPA040360: AB_2676939, HPA044088: AB_2678804" "unprognostic (5.24e-2)" "unprognostic (6.77e-2)" "unprognostic (1.72e-2)" "unprognostic (5.12e-2)" "unprognostic (1.85e-2)" "unprognostic (7.45e-5)" "unprognostic (1.66e-1)" "unprognostic (9.28e-3)" "unprognostic (3.28e-2)" "unprognostic (2.97e-2)" "unprognostic (2.74e-1)" "unprognostic (5.29e-2)" "prognostic unfavorable (5.59e-4)" "unprognostic (7.90e-3)" "unprognostic (2.92e-2)" "unprognostic (1.14e-2)" "unprognostic (2.06e-2)" 7.9 19.8 1.6 6.3 3.3 12.3 5.2 1.5 7.8 7.2 1.8 4.4 2.6 8.1 3.6 2.9 5.4 16.6 4.7 2.9 3.6 11.8 30.3 19.5 2.2 3.6 2.3 1.8 2.1 2.1 2.4 311.9 4.3 7.2 3.4 14.2 2.4 6.4 0.8 0.9 2.3 7.1 1.8 6.5 3.9 2.4 2.9 1.5 5.6 3.9 1.5 10.4 6.3 3.3 0.0 0.0 0.1 0.0 21.6 171.6 0.1 0.7 33.4 0.1 0.1 0.0 0.0 0.0 0.0 0.8 0.2 0.2 0.0 0.0 0.0 0.0 0.1 6.0 0.0 0.0 135.8 82.4 0.4 41.4 0.0 87.4 0.3 0.0 2.2 0.0 0.1 240.7 0.6 0.0 0.0 56.4 0.0 0.0 0.2 0.8 0.0 7.5 0.0 0.0 0.2 9.3 0.0 0.1 0.0 0.2 0.0 3.5 0.4 2.0 0.0 0.1 0.0 0.1 0.0 0.0 62.6 16.9 0.1 94.0 15.2 3.9 0.0 18.7 0.0 0.0 0.0 0.0 4.8 0.0 0.0 0.0 3.2 0.0 17.3 1.0 0.0 4.3 1.6 3.3 1.5 7.8 2.9 3.6 3.6 2.3 4.3 1.8 2.9 3.3 6.2 0.0 4.1 16.3 0.0 1.0 0.2 0.0 1.8 0.2 0.3 0.5 1.3 1.5 0.6 0.0 0.0 5.6 0.0 0.0 0.0 0.0 15.2 1.0 23.8 6.2 0.0 2.1 0.3 0.0 4.9 95.8 0.5 0.9 1.3 0.0 25.0 0.5 18.4 0.0 22.4 0.0 0.0 12.5 1.9 2.3 18.3 14.0 1.8 7.5 10.5 36.2 1.0 0.0 0.1 0.0 0.0 10.9 0.3 0.4 0.0 0.0 0.0 0.7 13.1 0.9 26.2 0.2 0.3 0.3 0.1 12.0 0.6 1.3 0.0 0.4 HGSNAT "FLJ32731, HGNAT, TMEM76" ENSG00000165102 "Heparan-alpha-glucosaminide N-acetyltransferase" Q68CP4 8 43140464-43202855 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Acyltransferase, Transferase" "Disease variant, Mucopolysaccharidosis, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029578 Approved NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 52: Non-specific - Transcription" "HPA029578: AB_10602423" "unprognostic (5.35e-2)" "unprognostic (4.61e-2)" "unprognostic (4.31e-2)" "unprognostic (1.36e-1)" "prognostic unfavorable (5.46e-4)" "unprognostic (3.94e-3)" "unprognostic (1.10e-1)" "unprognostic (6.54e-3)" "unprognostic (5.02e-2)" "prognostic favorable (6.33e-5)" "unprognostic (2.55e-2)" "unprognostic (5.48e-3)" "unprognostic (2.03e-1)" "unprognostic (1.27e-2)" "unprognostic (1.55e-1)" "unprognostic (1.72e-1)" "unprognostic (3.45e-2)" 32.3 20.0 13.1 17.5 13.0 21.7 27.8 10.6 13.5 35.0 13.8 25.4 18.4 30.1 30.6 24.0 29.0 25.9 23.3 13.3 17.6 20.0 26.6 24.5 11.7 13.3 12.0 35.9 29.9 22.7 30.7 28.4 13.2 26.9 17.2 12.5 25.9 23.3 14.4 35.4 20.9 25.1 11.4 17.6 23.2 7.6 15.8 11.3 26.9 17.6 15.7 25.2 28.7 13.0 27.4 36.0 8.9 18.0 71.7 53.8 13.3 30.5 36.2 21.8 19.3 5.1 39.2 14.8 20.5 42.9 15.2 15.5 4.0 18.5 12.7 6.4 6.9 16.3 22.2 8.1 23.0 3.7 2.5 36.2 25.9 11.7 24.9 34.5 39.2 7.0 7.5 22.1 40.4 10.0 14.8 7.2 8.0 16.3 5.4 1.6 16.1 7.7 36.1 22.8 4.7 14.0 39.0 12.6 17.4 19.0 43.7 20.9 46.3 33.2 5.4 20.9 12.7 17.9 18.2 6.1 26.8 6.3 20.8 0.2 8.8 9.4 2.7 5.4 3.0 1.9 2.3 2.8 15.8 2.1 1.7 1.9 3.2 8.8 8.6 2.0 1.7 5.0 13.1 13.0 10.6 13.5 13.3 17.6 13.3 12.0 13.2 11.4 15.8 13.0 39.1 16.0 31.9 48.0 26.7 18.0 19.5 22.6 8.6 50.6 23.9 21.7 10.5 28.6 17.8 51.5 50.1 39.2 30.1 27.2 3.9 26.7 0.5 23.5 42.1 37.8 24.1 15.3 61.8 28.1 39.4 34.3 32.6 36.5 8.2 51.2 49.6 23.5 29.2 25.2 76.3 28.0 18.3 34.3 58.8 3.2 35.1 43.3 19.6 44.0 33.5 13.5 34.0 50.8 43.8 29.9 17.0 31.6 19.8 20.7 31.4 9.9 23.5 39.6 26.3 30.2 28.2 1.1 3.0 22.3 21.2 30.1 25.0 37.4 21.7 17.7 HINT1 "HINT, PKCI-1, PRKCNH1" ENSG00000169567 "Histidine triad nucleotide binding protein 1" P49773 5 131155383-131224468 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Transcription, Transcription regulation" Hydrolase "Disease variant, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Proximal tubular cells: 3537.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044577 Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA 2800000 "Cluster 30: Non-specific - Translation" "Cluster 39: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 32: Non-specific - Translation" Cytosol "Nucleoplasm, Plasma membrane" "HPA044577: AB_10795618" "unprognostic (2.00e-1)" "unprognostic (9.27e-2)" "unprognostic (2.04e-2)" "unprognostic (1.03e-2)" "unprognostic (1.19e-1)" "unprognostic (1.35e-1)" "unprognostic (8.30e-3)" "unprognostic (2.48e-1)" "unprognostic (1.30e-2)" "unprognostic (6.49e-2)" "unprognostic (6.50e-3)" "unprognostic (4.43e-2)" "unprognostic (4.39e-3)" "unprognostic (2.08e-1)" "unprognostic (1.74e-1)" "unprognostic (1.67e-1)" "unprognostic (3.68e-1)" 132.6 175.0 235.7 139.8 245.1 259.3 172.7 241.6 326.2 117.6 243.8 227.6 176.1 119.6 187.5 181.3 165.6 108.0 167.2 245.9 247.8 256.7 474.2 119.0 206.5 241.6 237.2 121.5 165.5 285.6 152.5 87.5 249.1 155.1 226.5 110.8 172.8 116.4 334.1 170.0 196.3 124.2 242.6 126.9 136.5 80.1 240.8 166.5 177.2 278.4 192.3 152.9 129.7 245.3 437.1 522.7 448.2 877.2 273.1 297.1 441.3 300.3 230.9 235.4 272.1 547.1 516.8 563.3 625.7 329.6 569.1 253.4 315.4 635.3 244.1 500.0 514.6 199.1 814.0 771.9 532.6 349.4 65.4 400.1 618.6 295.8 528.2 533.7 314.1 727.8 313.4 1132.1 338.8 419.9 548.0 945.6 415.6 425.6 362.0 407.9 436.1 988.1 500.6 567.0 563.3 351.9 380.5 243.5 612.0 574.4 291.2 520.8 396.0 351.7 244.0 323.0 684.2 342.3 561.4 578.8 497.8 586.8 346.3 179.8 187.9 85.0 196.3 109.9 298.0 384.9 462.0 294.2 396.9 332.6 416.0 325.5 35.6 269.0 128.0 521.4 362.5 608.6 235.7 245.1 241.6 326.2 245.9 247.8 241.6 237.2 249.1 242.6 240.8 245.3 582.7 282.0 279.1 34.3 718.2 1301.2 1472.2 1928.1 889.5 191.2 1134.3 1831.1 517.0 1028.0 882.2 715.4 45.9 780.9 641.6 1245.1 1663.0 1024.5 783.0 718.9 443.7 501.2 698.1 669.7 53.8 774.3 1632.8 400.2 355.2 753.7 108.2 666.5 436.2 2380.1 887.1 148.0 48.0 947.2 915.5 472.4 906.9 206.3 392.4 447.0 965.8 34.7 1269.4 405.1 488.1 26.7 55.4 894.3 1094.2 418.6 679.7 1998.9 1690.3 3537.5 708.3 194.0 243.3 287.0 730.3 625.5 197.9 1109.1 1146.1 456.8 671.1 464.3 1280.4 1713.2 HK1 ENSG00000156515 "Hexokinase 1" P19367 10 69269984-69401884 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Glycolysis, Immunity, Inflammatory response, Innate immunity" "Allosteric enzyme, Kinase, Transferase" "Cancer-related genes, Charcot-Marie-Tooth disease, Disease variant, Mental retardation, Neurodegeneration, Neuropathy, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 4 "Early spermatids: 374.0;Horizontal cells: 304.5;Late spermatids: 1034.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007043, HPA007044, CAB010052" Supported Supported Mitochondria NA NA 560000 "Cluster 51: Monocytes - Innate immune response" "Cluster 39: Non-specific - Mitochondria" "Cluster 1: K-562 - Erythropoiesis" "Cluster 25: Spermatids - Spermatogenesis" Mitochondria "CAB010052: AB_627721, HPA007043: AB_1850652, HPA007044: AB_1079049" "unprognostic (8.80e-2)" "unprognostic (1.78e-1)" "unprognostic (2.03e-1)" "unprognostic (2.00e-3)" "unprognostic (1.15e-2)" "prognostic unfavorable (3.39e-6)" "unprognostic (1.23e-1)" "unprognostic (1.97e-1)" "unprognostic (4.29e-2)" "unprognostic (1.16e-1)" "unprognostic (3.93e-3)" "unprognostic (1.12e-1)" "unprognostic (1.37e-3)" "unprognostic (7.25e-2)" "unprognostic (1.40e-2)" "unprognostic (2.00e-3)" "unprognostic (3.86e-2)" 47.0 24.4 61.0 45.0 65.7 60.3 40.6 58.0 76.6 54.7 64.2 60.1 13.1 41.3 11.2 129.9 37.0 25.7 150.8 69.1 62.7 49.2 8.5 48.1 34.1 56.7 59.8 19.9 12.3 25.0 44.9 49.3 71.1 52.9 31.9 147.6 67.1 53.1 193.5 102.6 29.2 49.8 40.0 40.3 61.6 77.2 53.5 44.9 71.0 146.7 47.6 74.3 80.9 54.1 101.6 56.6 74.2 71.1 81.0 60.4 47.1 98.3 256.5 128.5 138.0 16.3 11.0 7.3 75.8 165.9 92.9 86.2 69.9 220.0 122.0 67.5 54.5 250.0 58.3 1.1 91.7 5.1 181.2 91.5 125.8 184.5 407.6 160.8 135.4 36.8 424.5 51.3 178.7 167.7 29.7 13.1 113.8 51.7 247.0 44.8 45.0 0.6 88.7 117.4 75.7 88.7 112.6 215.4 65.2 104.3 117.7 16.5 140.4 190.5 86.4 106.5 139.6 61.1 42.8 17.4 247.3 130.4 56.1 68.7 88.8 44.6 41.5 125.2 69.0 33.5 47.9 47.6 81.0 19.9 41.7 33.9 20.9 31.2 135.4 9.1 58.1 110.4 61.0 65.7 58.0 76.6 69.1 62.7 56.7 59.8 71.1 40.0 53.5 54.1 26.1 25.6 32.4 38.2 26.5 48.3 50.5 37.8 43.9 83.9 33.1 21.7 130.6 4.3 34.2 27.6 54.2 70.6 14.6 30.3 13.7 28.6 374.0 32.6 28.0 37.9 18.7 104.8 53.8 30.6 93.3 30.3 41.3 34.5 23.4 72.6 26.7 1.1 49.4 304.5 49.8 28.7 44.7 41.7 21.9 1034.1 15.2 51.3 37.4 29.0 35.3 32.9 20.6 14.1 3.5 54.6 11.1 18.4 19.1 29.1 0.7 1.1 30.7 95.5 19.7 22.2 43.1 5.3 6.2 86.0 51.7 118.9 30.5 28.3 19.3 43.5 HLA-DQB1 "CELIAC1, HLA-DQB, IDDM1" ENSG00000179344 "Major histocompatibility complex, class II, DQ beta 1" 6 32659467-32668383 "Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lung: 179.1;lymphoid tissue: 301.8" "Cell type enhanced" "Detected in many" "B-cells: 995.1;Langerhans cells: 4144.8;Macrophages: 1090.5;monocytes: 1038.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "classical monocyte: 153.5;intermediate monocyte: 142.9;memory B-cell: 159.2;myeloid DC: 386.3;naive B-cell: 169.1;plasmacytoid DC: 116.5" "Group enriched" "Detected in all" 6 "B-cells: 169.1;dendritic cells: 386.3;monocytes: 153.5" "Cell line enriched" "Detected in some" 6 "HDLM-2: 599.9" HPA013667 Enhanced Supported "Golgi apparatus,Rods & Rings" NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 16: Immune cells - Immune response" "Cluster 44: HDLM-2 - Immune response" "Cluster 41: Macrophages - Immune response" "Rods & Rings" "Golgi apparatus" "HPA013667: AB_1853932" "unprognostic (8.60e-3)" "unprognostic (1.91e-2)" "unprognostic (5.91e-2)" "unprognostic (9.85e-3)" "unprognostic (4.48e-1)" "unprognostic (5.30e-2)" "unprognostic (4.75e-2)" "unprognostic (1.06e-2)" "unprognostic (2.51e-2)" "unprognostic (1.48e-1)" "unprognostic (3.48e-2)" "unprognostic (3.94e-1)" "unprognostic (1.34e-2)" "unprognostic (3.13e-1)" "unprognostic (4.16e-1)" "unprognostic (2.43e-1)" "unprognostic (1.40e-1)" 56.6 23.9 2.2 77.8 2.2 40.0 45.3 2.7 3.1 19.9 3.0 45.8 0.2 18.9 126.9 21.3 22.2 43.6 21.6 2.0 3.6 34.3 37.1 179.1 301.8 4.7 3.8 7.4 14.3 10.6 21.3 10.1 2.9 17.1 39.0 1.7 24.2 11.9 9.6 31.8 78.0 11.2 4.6 139.3 128.0 7.0 3.1 108.2 26.3 0.0 122.3 89.9 16.9 5.5 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 93.9 2.2 0.0 0.0 19.2 0.0 19.2 0.0 599.9 13.4 0.0 0.0 0.0 0.0 0.2 7.8 0.0 3.0 0.0 0.0 0.0 0.0 2.9 0.0 1.8 0.0 7.2 0.1 0.9 0.1 0.0 0.0 0.0 0.1 0.2 0.0 1.3 0.0 0.1 1.6 1.1 1.4 0.0 3.3 10.9 0.2 0.0 0.6 0.8 0.4 68.7 2.1 66.0 47.1 0.1 0.0 0.3 153.5 27.9 12.8 142.9 6.6 159.2 6.9 20.0 386.3 169.1 0.4 6.3 11.8 10.4 41.1 116.5 41.1 217.0 2.2 2.2 2.7 3.1 2.0 3.6 4.7 3.8 2.9 4.6 3.1 5.5 162.9 41.7 181.1 0.0 995.1 89.9 8.7 23.1 31.3 5.1 16.8 32.1 3.2 27.1 40.7 18.4 10.4 1.4 188.2 10.3 7.9 38.8 16.5 4.1 1.0 135.3 22.8 37.2 0.2 20.0 3.0 18.8 41.8 5.2 38.5 7.9 25.0 2.3 422.1 0.0 0.8 24.7 12.2 487.3 4144.8 7.5 6.5 1090.5 97.8 8.4 1038.0 1.1 25.7 0.0 0.1 28.3 27.4 9.8 86.9 8.7 417.9 18.5 53.0 2.7 6.6 4.8 9.6 2.7 2.5 18.5 66.3 3.0 84.5 0.9 36.1 49.1 HLA-DRB1 HLA-DR1B ENSG00000196126 "Major histocompatibility complex, class II, DR beta 1" P01911 6 32578769-32589848 "Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins" "Adaptive immunity, Immunity" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lung: 581.3;lymphoid tissue: 651.4" "Cell type enhanced" "Detected in many" "B-cells: 2149.9;Langerhans cells: 11630.1;Macrophages: 3622.3;monocytes: 3104.1;Proximal enterocytes: 1849.6" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebral cortex: 47.5" "Immune cell enhanced" "Detected in all" "myeloid DC: 749.2" "Group enriched" "Detected in all" 9 "B-cells: 257.9;dendritic cells: 749.2;monocytes: 371.3" "Cell line enhanced" "Detected in many" "HDLM-2: 1181.9;HMC-1: 159.7;THP-1: 140.4;U-266/70: 150.3;U-698: 202.5;U-87 MG: 308.9" "CAB015400, CAB034021, HPA043151" Enhanced NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 64: Macrophages - Immune response" "Cluster 44: HDLM-2 - Immune response" "Cluster 41: Macrophages - Immune response" "CAB015400: AB_784538, CAB034021: AB_1124844, HPA043151: AB_2678342" "unprognostic (3.69e-3)" "unprognostic (3.66e-3)" "unprognostic (1.80e-2)" "unprognostic (2.40e-3)" "unprognostic (2.21e-1)" "unprognostic (5.45e-2)" "unprognostic (5.28e-2)" "unprognostic (1.22e-3)" "unprognostic (8.56e-2)" "unprognostic (3.00e-2)" "unprognostic (1.23e-1)" "unprognostic (2.08e-1)" "unprognostic (2.28e-3)" "unprognostic (6.16e-2)" "unprognostic (1.19e-1)" "unprognostic (5.10e-2)" "unprognostic (1.53e-1)" 311.4 162.1 7.2 220.8 7.8 61.3 239.4 6.4 47.5 121.4 11.1 113.5 2.4 90.3 140.6 71.7 119.4 66.9 134.6 6.2 11.4 217.5 100.6 581.3 651.4 6.8 7.1 40.4 50.8 0.0 80.2 13.6 6.9 88.4 135.3 5.2 93.8 0.4 58.3 122.5 353.2 11.1 9.9 516.2 232.3 25.5 9.2 254.3 129.5 0.0 257.4 116.2 91.5 13.4 0.6 0.0 0.0 0.3 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.1 2.4 17.1 0.0 0.0 1.9 0.0 4.7 0.0 1181.9 12.9 0.1 0.5 0.0 0.0 0.4 159.7 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 12.3 0.0 28.5 0.4 2.3 0.4 0.0 0.0 4.4 0.4 0.1 0.0 0.0 0.1 0.2 6.5 0.0 26.7 1.5 4.8 140.4 0.1 0.0 0.9 2.1 0.7 150.3 4.4 202.5 308.9 5.8 0.5 2.5 323.0 53.7 12.2 371.3 2.2 225.4 9.0 27.2 749.2 257.9 1.1 12.2 8.9 21.0 223.8 147.6 35.4 411.8 7.2 7.8 6.4 47.5 6.2 11.4 6.8 7.1 6.9 9.9 9.2 13.4 1241.9 147.4 609.1 0.0 2149.9 173.6 14.1 78.2 51.8 2.0 96.0 150.9 30.5 90.1 277.5 141.6 0.0 3.7 484.0 92.2 25.4 272.8 4.6 23.9 4.0 721.5 36.0 120.8 0.0 73.8 7.0 77.9 131.0 21.6 124.0 47.9 179.9 5.0 1417.7 0.0 0.0 92.7 30.5 1755.3 11630.1 12.3 14.9 3622.3 217.1 0.0 3104.1 7.7 55.6 0.0 0.0 89.1 308.9 26.7 120.2 21.0 1849.6 218.2 357.1 10.7 26.3 16.6 47.9 2.4 3.6 27.2 147.9 6.8 245.6 52.5 152.2 125.5 HMCN1 "ARMD1, FBLN6, FIBL-6, FIBL6" ENSG00000143341 "Hemicentin 1" Q96RW7 1 185734391-186190949 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" "Cell cycle, Cell division, Sensory transduction, Vision" "Age-related macular degeneration, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lung: 20.3" "Cell type enhanced" "Detected in many" "Adipocytes: 33.8;Endothelial cells: 21.4;Fibroblasts: 22.2;Horizontal cells: 26.9;Microglial cells: 45.0" "Cancer enriched" "Detected in many" 6 "melanoma: 14.6" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "fHDF/TERT166: 22.3;hTERT-RPE1: 20.1;MCF7: 76.5;SK-MEL-30: 50.2;WM-115: 43.9" "Not detected" "Not detected" "Region enhanced" "Detected in many" "olfactory bulb: 9.9" "HPA008220, HPA051677" Uncertain Approved "Golgi apparatus,Cytosol" "Secreted to extracellular matrix" NA NA 9200000 "Cluster 35: T-regs - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Golgi apparatus, Cytosol" "HPA008220: , HPA051677: AB_2681572" "unprognostic (1.90e-1)" "unprognostic (2.66e-1)" "unprognostic (8.00e-2)" "unprognostic (1.10e-1)" "unprognostic (7.77e-2)" "unprognostic (1.08e-1)" "unprognostic (1.96e-1)" "unprognostic (4.36e-2)" "unprognostic (2.20e-2)" "unprognostic (1.00e-1)" "unprognostic (1.15e-1)" "unprognostic (1.73e-1)" "prognostic unfavorable (3.59e-7)" "unprognostic (1.22e-2)" "unprognostic (5.17e-3)" "unprognostic (3.52e-1)" "unprognostic (2.00e-3)" 9.7 1.4 1.3 0.6 1.2 0.0 8.4 0.9 1.1 3.7 1.3 9.0 0.9 1.9 2.5 5.4 1.8 6.5 8.4 0.8 1.1 2.5 7.8 20.3 0.4 1.5 1.9 3.9 0.9 0.9 3.2 4.8 1.5 7.5 2.8 0.6 7.7 1.4 4.8 4.1 3.1 4.3 1.4 8.4 1.7 2.6 1.7 0.8 3.2 7.0 2.4 1.8 3.8 0.9 0.2 0.1 1.6 0.0 4.7 4.7 0.0 0.5 0.9 0.3 0.5 0.0 0.1 1.9 0.2 22.3 1.6 5.0 0.1 0.2 0.1 0.2 0.0 0.5 0.0 0.0 0.3 0.0 0.0 4.7 0.0 5.6 0.4 20.1 2.8 0.0 0.2 0.0 0.0 76.5 0.0 0.0 3.3 0.1 0.1 0.0 0.0 0.0 3.2 0.0 0.2 0.0 0.0 0.0 50.2 4.5 0.1 0.0 0.0 13.7 1.3 0.0 5.1 0.2 0.0 0.3 2.7 0.0 43.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 1.3 1.2 0.9 1.1 0.8 1.1 1.5 1.9 1.5 1.4 1.7 0.9 33.8 3.2 7.0 0.3 0.0 3.2 0.2 4.9 2.2 1.7 1.2 1.8 2.8 0.0 0.8 0.0 0.0 0.1 0.2 0.3 0.0 0.0 8.3 0.6 1.5 21.4 0.0 0.0 1.1 0.0 0.8 22.2 0.0 0.9 0.0 5.2 7.9 1.9 0.1 26.9 3.8 0.0 0.0 0.3 2.8 2.7 3.7 0.4 5.4 45.0 0.0 0.1 0.0 3.0 1.5 0.0 0.0 2.2 1.2 0.1 0.0 0.2 1.0 0.0 0.0 2.5 7.7 0.5 0.1 0.4 1.7 0.0 0.4 0.1 0.0 0.2 HNRNPA1 "ALS20, hnRNP-A1, HNRPA1" ENSG00000135486 "Heterogeneous nuclear ribonucleoprotein A1" P09651 12 54280193-54287088 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, mRNA processing, mRNA splicing, mRNA transport, Transport" "Ribonucleoprotein, RNA-binding" "Amyotrophic lateral sclerosis, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001609, HPA001666, HPA005812, HPA007185, CAB010894" Supported Enhanced Nucleoplasm NA NA 9300000 "Cluster 39: Non-specific - mRNA processing" "Cluster 50: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 32: Non-specific - Translation" Nucleoplasm "CAB010894: AB_261962, HPA001609: AB_2666383, HPA001666: AB_1850836, HPA005812: AB_2667441, HPA007185: AB_2667768" "unprognostic (1.38e-3)" "unprognostic (1.90e-1)" "unprognostic (1.59e-2)" "unprognostic (5.98e-3)" "unprognostic (2.82e-2)" "unprognostic (2.46e-1)" "unprognostic (1.22e-2)" "unprognostic (9.71e-2)" "unprognostic (3.34e-2)" "unprognostic (2.91e-2)" "unprognostic (3.72e-2)" "unprognostic (3.51e-2)" "unprognostic (6.88e-3)" "unprognostic (2.32e-2)" "unprognostic (1.14e-1)" "unprognostic (1.48e-1)" "unprognostic (9.54e-3)" 531.6 410.2 339.5 528.1 362.6 1087.9 640.6 348.2 424.9 750.3 326.5 542.3 447.5 625.3 474.8 510.3 589.2 214.7 391.4 320.7 363.0 501.4 277.0 380.6 685.7 363.3 348.2 1410.2 556.7 359.8 327.2 447.9 364.8 458.9 445.9 261.2 398.9 409.6 437.4 506.3 436.4 382.1 380.9 434.1 431.0 168.9 343.9 1010.9 396.3 174.4 824.8 513.7 580.9 372.6 1246.7 815.8 2072.5 1717.3 550.5 1057.0 1204.0 911.9 1405.6 1311.7 1153.1 1225.4 1306.6 3183.8 983.8 671.8 354.7 1045.9 1486.5 1393.4 1425.5 1216.4 1041.7 1700.0 1156.1 2250.0 320.4 2712.4 1078.2 845.2 568.3 642.9 1056.1 868.7 1408.6 1474.7 1930.7 1215.3 968.2 1244.6 2969.1 2880.9 2571.8 844.0 675.9 2911.7 1588.9 1574.1 1239.4 1395.0 1260.4 1739.0 758.0 1675.2 1392.3 1031.6 1010.9 1744.5 1063.1 781.6 1164.2 820.6 1395.1 1185.7 1349.3 2249.7 572.5 1646.7 744.0 140.4 423.5 165.9 572.8 513.1 893.3 576.5 746.2 657.5 704.5 501.8 851.2 810.1 41.0 823.3 437.7 556.5 683.4 1333.2 339.5 362.6 348.2 424.9 320.7 363.0 363.3 348.2 364.8 380.9 343.9 372.6 372.4 304.5 521.4 20.9 1018.9 1416.1 1039.8 1252.9 900.9 254.1 745.1 541.3 166.2 697.7 612.0 294.3 93.8 2076.2 900.8 407.3 739.6 1296.2 181.5 304.7 706.7 624.8 824.0 1032.4 16.5 2124.2 2894.5 600.5 458.7 400.7 528.9 790.7 562.2 183.1 1006.9 109.4 18.3 1130.9 459.8 863.9 1048.2 115.6 1050.7 609.2 588.7 21.5 1374.4 411.0 1304.9 23.1 34.1 1162.7 731.2 741.8 702.2 696.8 693.2 838.6 288.3 195.2 453.6 714.5 704.1 217.0 338.1 1030.6 1261.9 2178.8 958.6 690.9 1543.8 897.8 HNRNPU "C1orf199, FLJ30202, FLJ37978, HNRNPU-AS1, HNRPU, NCRNA00201, SAF-A" ENSG00000153187 "Heterogeneous nuclear ribonucleoprotein U" Q00839 1 244840638-244864560 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Biological rhythms, Cell cycle, Cell division, Differentiation, Host-virus interaction, Mitosis, mRNA processing, mRNA splicing, Transcription, Transcription regulation" "Activator, Chromatin regulator, Developmental protein, DNA-binding, Repressor, Ribonucleoprotein, RNA-binding" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011532, HPA041057, HPA058707" Supported Enhanced Nucleoplasm NA NA 2100000 "Cluster 26: Non-specific - Mitochondria" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 36: Stromal cells - Cell proliferation" Nucleoplasm "CAB011532: AB_732983, HPA041057: AB_2677278, HPA058707: AB_2683796" "unprognostic (1.38e-1)" "unprognostic (1.67e-1)" "unprognostic (1.31e-2)" "unprognostic (1.99e-1)" "unprognostic (3.63e-2)" "unprognostic (2.25e-1)" "prognostic unfavorable (8.88e-5)" "unprognostic (2.26e-2)" "unprognostic (4.09e-3)" "unprognostic (1.87e-2)" "unprognostic (6.59e-2)" "unprognostic (1.12e-2)" "unprognostic (7.45e-2)" "unprognostic (1.21e-1)" "unprognostic (3.01e-2)" "unprognostic (2.98e-1)" "unprognostic (4.62e-1)" 110.3 111.9 123.7 76.1 132.5 177.5 100.9 131.8 139.8 101.6 122.3 93.3 65.5 103.0 121.3 99.9 106.6 62.7 92.7 122.5 123.5 129.9 105.6 80.7 98.3 125.7 127.9 134.5 99.4 109.6 88.2 96.0 127.3 92.2 84.2 126.3 86.8 79.5 116.5 91.9 94.5 76.7 129.8 103.0 95.0 90.2 127.6 141.2 103.6 61.6 115.5 97.0 86.8 144.6 308.9 242.9 311.8 249.4 160.5 136.4 307.9 215.2 138.2 193.3 171.1 234.0 198.6 481.9 195.6 183.0 185.4 235.3 424.4 244.0 304.5 204.8 280.2 417.4 203.4 360.7 168.8 482.7 242.9 156.2 143.9 211.6 220.1 169.8 200.4 296.9 553.0 174.0 264.3 221.2 517.8 497.8 545.5 227.4 217.2 510.6 392.7 261.9 314.3 222.9 260.6 257.5 339.2 220.4 280.9 226.8 305.2 531.7 244.5 192.6 283.7 207.0 384.3 283.4 332.9 458.6 156.8 403.1 282.2 23.0 14.4 20.6 18.0 12.9 19.2 22.6 22.0 22.1 15.8 21.8 25.5 21.5 20.6 19.8 15.0 31.3 21.3 10.1 123.7 132.5 131.8 139.8 122.5 123.5 125.7 127.9 127.3 129.8 127.6 144.6 269.6 326.9 375.8 67.9 271.9 271.2 416.4 137.1 277.2 149.5 254.3 166.5 186.8 118.7 281.4 193.1 183.5 202.2 323.4 163.7 97.8 215.5 389.9 283.4 530.1 248.6 198.1 269.4 61.8 180.9 259.5 267.1 202.9 429.8 363.6 375.3 133.2 121.9 184.5 141.3 65.2 208.0 109.9 223.7 268.6 481.9 153.7 402.7 122.7 45.9 251.4 151.4 228.6 67.8 107.7 188.9 141.8 142.6 331.6 215.8 141.4 133.2 240.1 213.7 144.7 317.0 364.3 194.9 162.7 292.7 239.2 252.7 310.6 379.9 234.6 288.1 HOMER2 "CPD, Cupidin, DFNA68, HOMER-2, HOMER-2A, HOMER-2B, Vesl-2" ENSG00000103942 "Homer scaffold protein 2" Q9NSB8 15 82836946-82986153 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Hearing "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pancreas: 226.2" "Cell type enhanced" "Detected in many" "Cholangiocytes: 215.9;Endometrial ciliated cells: 184.4;Glandular and luminal cells: 151.9" "Cancer enhanced" "Detected in many" "prostate cancer: 15.2" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "myeloid DC: 1.1" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "HAP1: 52.7;Karpas-707: 92.6;SCLC-21H: 50.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040134, CAB079014" Uncertain Supported Supported Cytosol NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 2: Karpas-707 - Immune response" "Cluster 44: Endometrium - Transcription" Cytosol "CAB079014: , HPA040134: AB_10795272" "unprognostic (7.34e-2)" "unprognostic (3.58e-2)" "unprognostic (5.75e-4)" "unprognostic (3.31e-3)" "unprognostic (4.85e-2)" "unprognostic (1.24e-1)" "unprognostic (1.04e-2)" "unprognostic (7.13e-3)" "unprognostic (2.69e-1)" "unprognostic (1.40e-1)" "unprognostic (1.02e-1)" "unprognostic (2.75e-1)" "unprognostic (8.16e-4)" "unprognostic (2.30e-1)" "unprognostic (3.21e-2)" "unprognostic (1.26e-1)" "unprognostic (4.45e-3)" 1.5 6.3 6.5 1.1 7.6 4.6 26.9 8.2 12.8 23.1 69.8 3.2 8.5 8.4 33.7 21.2 25.9 12.8 21.9 16.2 7.8 7.2 46.4 5.3 1.3 5.7 4.6 2.6 226.2 5.1 7.7 0.6 5.7 57.7 1.0 6.4 71.2 4.6 108.7 45.0 1.3 1.4 4.1 4.8 55.4 6.1 6.0 3.0 28.9 55.9 3.6 1.3 11.7 8.0 16.6 6.9 7.2 18.9 0.2 0.1 1.1 1.1 0.0 1.7 0.6 1.2 11.5 0.1 8.8 8.4 8.3 9.1 52.7 24.9 1.2 45.1 33.5 10.6 0.4 8.3 0.7 0.4 32.6 1.8 37.4 0.6 2.1 1.9 0.0 20.6 0.4 92.6 7.0 48.4 3.2 1.1 11.4 1.4 5.1 2.2 11.5 5.5 25.3 20.1 50.8 13.1 18.6 14.1 17.6 5.2 17.1 3.5 0.2 17.2 31.7 1.3 15.3 11.8 5.9 1.8 29.0 0.4 6.4 0.1 0.1 0.4 0.0 0.1 0.0 0.2 0.1 0.0 1.1 0.3 0.1 0.0 0.4 0.0 0.0 0.5 0.2 0.3 6.5 7.6 8.2 12.8 16.2 7.8 5.7 4.6 5.7 4.1 6.0 8.0 1.9 16.0 10.1 24.8 3.8 4.6 56.1 7.2 10.2 15.0 39.7 20.4 23.0 215.9 14.6 11.0 18.8 1.1 4.4 0.3 7.9 29.6 1.9 184.4 15.4 12.4 3.0 8.2 24.8 76.5 0.4 3.6 14.3 151.9 0.0 11.9 1.4 59.6 13.3 20.2 35.1 0.4 0.0 3.2 73.9 4.0 1.8 9.2 37.4 7.5 7.9 18.5 1.0 6.6 11.8 25.9 0.1 0.7 4.1 81.5 0.7 12.1 4.0 5.1 0.0 7.8 4.8 5.5 16.6 19.4 6.0 0.7 3.1 4.1 0.4 30.5 HPCA DYT2 ENSG00000121905 Hippocalcin P84074 1 32885994-32898441 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Disease variant, Dystonia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 14 "brain: 517.5" "Group enriched" "Detected in many" 7 "Bipolar cells: 198.3;Early spermatids: 155.4;Late spermatids: 119.7" "Cancer enriched" "Detected in many" 9 "glioma: 8.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 7 "SCLC-21H: 4.9" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 6 "basal ganglia: 1309.6;hippocampal formation: 990.7" "CAB012340, HPA043245" Enhanced NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 56: Bipolar cells - Visual perception" "CAB012340: AB_2120209, HPA043245: AB_2678385" "unprognostic (4.60e-2)" "unprognostic (5.96e-3)" "unprognostic (2.16e-3)" "unprognostic (1.19e-3)" "unprognostic (6.72e-3)" "unprognostic (5.18e-2)" "unprognostic (9.08e-3)" "unprognostic (6.71e-3)" "unprognostic (1.18e-1)" "unprognostic (1.33e-1)" "unprognostic (2.32e-3)" "unprognostic (1.98e-2)" "unprognostic (2.36e-2)" "unprognostic (1.12e-2)" "unprognostic (6.42e-2)" "unprognostic (3.09e-2)" "unprognostic (2.85e-3)" 0.2 0.4 99.4 0.0 517.5 0.0 0.1 50.3 322.2 0.7 37.5 0.7 0.1 0.5 0.0 0.1 0.3 0.2 0.3 326.8 52.2 0.3 0.2 0.1 0.0 43.0 54.8 0.6 0.5 0.3 1.8 0.0 41.6 0.5 0.4 18.4 0.1 0.1 0.2 0.1 0.4 0.2 54.8 0.1 0.2 3.6 105.8 0.0 0.4 0.0 0.0 0.2 0.4 82.6 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.6 0.1 0.2 0.0 0.0 0.0 0.1 0.1 0.4 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.3 0.0 0.0 4.9 0.6 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.5 0.4 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 99.4 517.5 50.3 322.2 326.8 52.2 43.0 54.8 41.6 54.8 105.8 82.6 0.1 0.0 0.0 3.6 0.0 0.0 1.4 0.5 0.0 198.3 0.4 0.9 0.4 0.0 0.1 0.0 6.2 0.1 0.1 1.7 0.0 0.3 155.4 0.0 0.4 0.3 18.0 0.0 21.9 0.5 0.3 0.7 0.0 0.1 0.0 0.9 0.0 0.0 0.1 13.5 7.8 2.8 0.0 0.0 0.0 119.7 1.2 0.1 0.0 2.8 0.0 9.1 0.0 4.5 3.7 0.3 5.9 0.4 0.0 1.3 2.0 2.0 0.2 19.3 0.0 0.1 0.5 4.2 8.5 0.1 0.3 0.1 0.0 0.0 2.2 1.4 HPDL "4-HPPD-L, GLOXD1, MGC15668" ENSG00000186603 "4-hydroxyphenylpyruvate dioxygenase like" Q96IR7 1 45326895-45328679 "Human disease related genes, Predicted intracellular proteins" "Dioxygenase, Oxidoreductase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in some" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 29.1;Gastric mucus-secreting cells: 8.2;Undifferentiated cells: 7.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 111.7;HL-60: 34.2;NB-4: 42.8;SK-BR-3: 72.5" "Low region specificity" "Detected in many" "HPA031997, HPA057346" Supported Nucleoplasm,Mitochondria No NA "Cluster 39: Non-specific - mRNA processing" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 28: BEWO - Transcription regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Mitochondria Nucleoplasm "HPA031997: AB_10602909, HPA057346: AB_2683415" "prognostic favorable (1.81e-4)" "unprognostic (1.36e-1)" "unprognostic (2.46e-1)" "prognostic unfavorable (1.60e-5)" "unprognostic (1.02e-2)" "unprognostic (6.71e-2)" "unprognostic (3.93e-3)" "unprognostic (1.25e-1)" "unprognostic (1.63e-1)" "prognostic favorable (1.03e-4)" "unprognostic (1.08e-3)" "unprognostic (2.52e-2)" "unprognostic (6.66e-2)" "unprognostic (1.26e-2)" "unprognostic (1.00e-1)" "unprognostic (3.03e-2)" "unprognostic (1.43e-1)" 0.4 0.2 1.0 1.3 1.3 1.8 0.4 3.1 1.0 1.2 0.0 3.7 2.4 0.6 0.0 2.2 0.6 0.0 0.3 0.9 0.9 0.6 0.1 0.3 1.0 1.3 1.2 0.6 0.3 0.0 0.3 2.1 1.3 0.6 2.8 0.4 1.0 0.2 1.6 0.8 2.5 0.3 0.8 1.8 3.4 0.3 1.3 1.2 0.6 0.6 0.9 0.5 1.1 1.3 0.1 1.1 0.5 0.1 0.1 0.4 111.7 1.5 0.0 2.0 0.4 28.7 7.7 5.8 0.3 1.5 0.0 7.0 0.0 0.4 0.7 0.2 0.3 0.6 13.4 0.0 0.7 34.2 0.9 1.1 0.2 1.2 0.0 0.1 2.2 0.2 0.0 5.2 0.2 14.6 22.1 42.8 0.5 23.0 0.0 6.6 0.1 19.4 0.4 0.4 22.2 1.5 14.6 72.5 11.4 1.6 0.2 6.3 1.0 0.0 0.3 1.3 0.0 0.9 0.6 21.3 0.1 0.1 1.4 0.0 0.0 0.0 0.1 0.0 0.3 0.6 0.1 0.2 0.2 0.0 0.2 0.1 0.0 0.5 0.0 0.0 0.1 0.1 1.0 1.3 3.1 1.0 0.9 0.9 1.3 1.2 1.3 0.8 1.3 1.3 0.1 0.0 0.0 2.9 1.0 0.1 2.3 0.5 1.2 0.2 0.7 1.0 0.4 0.0 0.1 0.0 0.0 29.1 0.3 3.0 3.9 0.4 0.2 0.1 1.5 0.7 1.2 4.2 0.0 0.0 5.8 0.8 8.2 0.2 0.0 0.9 0.4 0.1 2.5 0.0 0.2 3.3 0.0 0.0 0.3 0.0 0.3 0.2 0.0 0.0 0.1 0.0 0.0 0.5 0.0 1.8 1.9 0.0 5.2 2.2 0.4 0.3 0.0 0.4 0.0 0.6 0.8 0.0 1.9 2.1 1.1 5.1 0.4 1.2 7.6 1.5 HSF4 CTM ENSG00000102878 "Heat shock transcription factor 4" Q9ULV5 16 67164681-67169945 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Stress response, Transcription, Transcription regulation" "Activator, DNA-binding, Repressor" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 69.2" "Cell type enhanced" "Detected in many" "Astrocytes: 38.5;Excitatory neurons: 30.9;Horizontal cells: 43.7;Inhibitory neurons: 30.0;Leydig cells: 32.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "hTERT-RPE1: 17.1;T-47d: 12.9;U-266/70: 22.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA048584 Supported "Nuclear speckles" NA NA "Cluster 22: Non-specific - Unknown function" "Cluster 29: U-266 - Adaptive immune response" "Cluster 62: Horizontal cells - Visual perception" "Nuclear speckles" "HPA048584: AB_2680452" "unprognostic (1.90e-1)" "unprognostic (3.05e-2)" "prognostic unfavorable (8.24e-5)" "unprognostic (9.20e-3)" "unprognostic (2.61e-1)" "unprognostic (1.43e-1)" "unprognostic (8.98e-2)" "unprognostic (1.36e-1)" "unprognostic (4.06e-2)" "unprognostic (2.45e-1)" "unprognostic (2.85e-2)" "unprognostic (4.26e-3)" "prognostic unfavorable (2.19e-6)" "unprognostic (1.20e-1)" "unprognostic (1.33e-1)" "unprognostic (4.48e-2)" "unprognostic (8.74e-3)" 12.4 23.7 43.6 1.3 44.3 1.8 12.7 44.6 69.2 17.9 39.2 10.1 4.8 12.4 4.8 11.0 21.1 3.6 20.0 44.6 43.7 17.1 20.3 8.7 1.6 45.0 41.9 19.8 35.9 4.3 30.1 3.3 46.4 28.3 1.8 5.6 19.0 1.9 25.9 14.5 6.1 2.1 41.3 6.0 14.4 7.0 43.3 1.1 17.9 4.1 1.1 18.8 10.9 45.8 1.6 1.1 0.0 1.1 0.5 3.0 5.2 0.5 0.6 0.2 0.0 2.4 3.5 0.1 2.5 1.1 0.7 5.9 0.4 0.7 0.2 2.3 2.2 0.6 4.5 3.1 2.3 0.3 4.4 1.3 4.8 0.2 2.5 17.1 0.9 4.0 1.5 5.1 2.3 1.5 0.8 1.8 0.1 3.4 3.2 2.0 1.7 8.7 4.4 2.5 3.5 7.6 4.9 3.0 7.8 2.1 12.9 4.5 0.9 1.6 1.6 6.4 1.5 22.3 3.7 1.5 4.9 1.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 43.6 44.3 44.6 69.2 44.6 43.7 45.0 41.9 46.4 41.3 43.3 45.8 2.6 3.2 7.7 38.5 1.1 3.1 3.4 2.9 4.6 10.8 9.1 7.7 5.3 4.3 2.7 3.7 2.1 1.0 0.7 2.9 0.0 1.0 0.5 4.1 2.8 1.6 1.2 0.0 30.9 1.3 0.6 6.0 14.8 7.0 1.3 2.3 2.9 5.7 21.9 43.7 30.0 3.0 2.0 0.8 2.5 1.8 32.9 4.6 10.6 5.6 1.5 8.8 0.0 4.0 15.2 1.4 3.5 22.2 1.5 4.0 0.4 2.4 4.8 11.4 0.0 5.4 3.2 0.4 2.3 3.6 3.4 0.7 0.9 1.9 2.9 2.0 HSPB1 "CMT2F, Hs.76067, Hsp25, HSP27, HSP28" ENSG00000106211 "Heat shock protein family B (small) member 1" P04792 7 76302673-76304295 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, Stress response" Chaperone "Cancer-related genes, Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "esophagus: 5909.6" "Cell type enhanced" "Detected in all" "Basal prostatic cells: 16589.4;Exocrine glandular cells: 6539.7;Squamous epithelial cells: 6300.1;Urothelial cells: 13091.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "hTCEpi: 2482.8;MCF7: 3979.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000497, CAB004439, CAB047330, CAB047331, CAB047332" Enhanced Enhanced "Plasma membrane,Cytosol" NA NA 19000000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 22: Epithelial cell types - Mixed function" "Plasma membrane, Cytosol" "CAB004439: AB_627755, CAB047330: , CAB047331: , CAB047332: , HPA000497: AB_1851172" "unprognostic (2.55e-1)" "unprognostic (7.25e-3)" "prognostic unfavorable (9.94e-5)" "unprognostic (7.07e-3)" "unprognostic (3.47e-3)" "unprognostic (6.61e-3)" "unprognostic (4.08e-3)" "unprognostic (4.50e-2)" "unprognostic (1.27e-1)" "unprognostic (9.78e-2)" "unprognostic (8.70e-2)" "unprognostic (2.21e-1)" "unprognostic (5.72e-2)" "unprognostic (5.18e-2)" "unprognostic (2.67e-1)" "unprognostic (2.56e-1)" "unprognostic (3.63e-1)" 964.4 856.4 810.6 329.6 835.1 52.3 560.5 821.6 1798.8 2123.4 864.3 2043.6 208.7 2824.2 131.7 5909.6 993.8 217.2 2981.9 776.6 944.5 986.4 554.9 790.9 99.0 894.1 838.7 731.6 751.7 221.1 303.3 324.3 870.8 979.0 73.8 10.2 1075.3 522.5 3669.8 2258.3 523.8 1066.9 808.2 224.5 770.3 99.8 840.0 218.7 627.1 628.1 279.3 1579.4 3398.4 869.5 1251.1 902.4 79.5 576.8 487.3 447.5 5.1 514.9 249.8 260.9 325.8 84.8 660.7 8.5 389.1 599.1 514.1 1094.2 359.0 279.6 76.5 690.9 106.4 41.5 611.4 345.5 267.9 69.9 466.5 542.8 2482.8 370.0 50.5 436.6 831.3 169.5 459.4 1079.7 276.5 3979.7 117.1 508.9 407.4 212.7 800.6 417.3 195.8 974.5 342.8 423.2 7.6 529.1 363.8 1323.3 456.0 224.5 1674.9 551.6 504.2 778.8 1200.3 221.7 1310.1 85.7 145.9 10.7 575.9 247.2 579.5 19.7 13.6 10.9 58.8 78.2 28.1 115.0 92.4 62.1 31.5 105.5 102.1 88.2 5.8 79.7 112.8 56.5 64.5 46.7 810.6 835.1 821.6 1798.8 776.6 944.5 894.1 838.7 870.8 808.2 840.0 869.5 708.2 272.4 186.4 78.4 145.4 1849.8 16589.4 3603.0 1728.4 243.4 312.5 174.4 822.3 264.5 1899.4 1144.0 323.2 161.7 62.0 824.2 1500.7 2021.4 11.9 1181.8 1060.9 1038.7 422.0 136.1 4.3 6539.7 399.4 998.5 219.2 1227.1 216.7 136.3 725.7 234.7 1199.8 70.7 2.2 433.0 1245.1 147.7 2828.9 30.8 299.5 1024.8 2056.2 35.6 188.0 171.4 50.4 8.0 2.7 2719.4 1417.1 534.5 296.9 3854.8 95.3 2324.4 1253.9 29.2 611.4 551.2 2129.1 20.3 105.5 6300.1 2241.7 2432.7 758.2 68.2 390.5 13091.2 HSPB11 "C1orf41, FAP232, HSPCO34, IFT25, PP25" ENSG00000081870 "Heat shock protein family B (small) member 11" Q9Y547 1 53916574-53945699 "Human disease related genes, Predicted intracellular proteins" "Differentiation, Protein transport, Spermatogenesis, Stress response, Transport" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Respiratory ciliated cells: 412.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030140 Uncertain Approved Nucleoplasm,Cytosol NA NA 38000 "Cluster 44: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 6: T47d - Mammary gland" "Cluster 49: Ciliated cells - Cilium organization" Nucleoplasm Cytosol "HPA030140: AB_10600713" "unprognostic (5.73e-2)" "unprognostic (6.37e-3)" "unprognostic (8.81e-2)" "unprognostic (2.99e-3)" "unprognostic (1.01e-2)" "unprognostic (3.84e-2)" "prognostic unfavorable (9.58e-7)" "unprognostic (5.12e-1)" "unprognostic (6.70e-3)" "unprognostic (8.31e-3)" "unprognostic (2.22e-1)" "unprognostic (1.84e-1)" "prognostic unfavorable (1.03e-6)" "unprognostic (1.84e-2)" "unprognostic (2.74e-1)" "unprognostic (5.38e-2)" "unprognostic (1.97e-2)" 25.9 36.4 36.2 34.1 37.1 61.2 46.5 35.5 49.9 33.9 46.4 31.9 25.0 42.6 70.5 30.1 79.6 26.8 26.6 38.4 36.9 35.3 55.1 29.7 62.5 35.5 35.5 41.8 26.4 30.8 23.1 41.6 35.6 34.9 34.5 29.8 24.0 36.6 11.4 37.3 26.0 36.8 36.3 34.8 36.8 30.7 35.3 55.8 96.8 19.6 62.3 39.5 19.2 38.6 115.4 50.3 141.8 31.2 51.1 67.7 59.4 95.8 91.4 142.5 163.8 122.2 60.5 134.7 77.1 69.6 251.8 88.9 62.2 99.5 168.7 114.6 91.6 166.6 108.1 163.7 58.2 83.7 108.0 70.0 76.7 135.5 37.0 88.4 77.4 82.5 102.3 30.6 184.4 24.9 184.8 132.4 59.5 96.1 111.5 125.5 184.3 72.5 118.3 128.7 74.2 59.8 140.7 64.8 95.4 142.7 396.4 118.5 52.7 92.4 115.1 104.9 107.8 54.6 97.3 141.7 148.5 78.1 81.5 171.2 47.4 130.6 87.0 65.9 78.8 95.6 85.6 104.7 56.8 76.9 67.1 84.9 33.5 109.4 71.8 121.8 122.0 58.3 36.2 37.1 35.5 49.9 38.4 36.9 35.5 35.5 35.6 36.3 35.3 38.6 37.8 32.1 31.4 14.7 54.3 106.4 79.6 244.6 68.9 22.4 67.5 73.2 42.7 42.9 134.6 51.5 8.4 181.9 72.0 42.4 117.4 60.4 55.7 249.2 60.0 40.7 77.3 48.6 18.2 65.7 101.3 59.0 27.5 60.3 61.5 59.3 31.8 64.9 115.0 13.5 16.9 42.2 217.7 46.5 74.8 15.7 61.5 57.2 78.2 11.2 80.5 87.8 70.0 13.0 22.9 79.6 52.0 63.6 80.8 70.5 54.7 119.2 412.1 19.8 39.5 32.6 93.0 130.0 97.9 66.4 82.8 116.8 73.7 120.3 39.7 118.0 HSPB3 HSPL27 ENSG00000169271 "Heat shock protein family B (small) member 3" Q12988 5 54455699-54456377 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Stress response" "Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 17 "heart muscle: 406.9;skeletal muscle: 217.2;tongue: 218.9" "Cell type enriched" "Detected in some" 18 "Cardiomyocytes: 398.1" "Cancer enriched" "Detected in many" 6 "head and neck cancer: 7.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ hTERT+: 86.3;fHDF/TERT166: 39.1;HSkMC: 16.3;LHCN-M2: 12.6" "Low region specificity" "Detected in many" "Not detected" "Not detected" HPA062124 Supported "Nuclear speckles" NA NA "Cluster 38: Heart - Muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 54: Cardiomyocytes - Muscle contraction" "Nuclear speckles" "HPA062124: AB_2684690" "unprognostic (1.44e-1)" "unprognostic (2.21e-1)" "unprognostic (1.78e-3)" "unprognostic (3.06e-1)" "unprognostic (2.25e-3)" "unprognostic (1.13e-1)" "unprognostic (4.41e-3)" "unprognostic (6.42e-2)" "unprognostic (1.85e-1)" "unprognostic (2.70e-2)" "unprognostic (2.73e-1)" "unprognostic (2.82e-2)" "unprognostic (7.15e-2)" 1.4 0.2 4.6 0.1 5.6 0.2 2.1 4.0 7.5 0.9 4.1 5.2 0.2 7.5 0.4 16.5 3.0 0.2 406.9 6.3 7.2 0.4 0.1 2.8 0.0 4.1 4.0 1.0 0.1 0.0 3.6 0.1 4.4 8.6 2.1 1.6 6.7 0.8 217.2 2.2 0.9 10.4 4.1 0.7 0.9 1.8 4.1 0.7 0.3 218.9 0.0 3.7 0.8 6.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 86.3 0.1 0.1 0.4 0.0 0.0 0.3 39.1 0.1 4.8 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.4 0.0 0.0 16.3 5.3 0.0 0.0 0.0 0.0 0.0 0.3 0.0 12.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.0 4.4 0.1 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 4.6 5.6 4.0 7.5 6.3 7.2 4.1 4.0 4.4 4.1 4.1 6.4 0.0 0.0 0.0 0.3 0.0 6.4 0.4 3.2 0.0 0.1 0.0 0.0 398.1 0.0 0.3 0.0 0.0 0.1 0.0 10.5 0.0 0.0 0.1 0.7 0.2 3.5 0.0 0.0 4.3 0.0 0.0 14.4 0.0 1.3 0.0 0.1 0.0 0.0 0.1 1.7 6.5 0.0 0.0 0.0 4.9 0.4 0.6 0.2 3.6 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.5 6.6 21.3 7.2 0.4 0.0 0.0 5.3 0.1 0.2 0.1 0.3 0.3 HSPB8 "CMT2L, E2IG1, H11, HSP22" ENSG00000152137 "Heat shock protein family B (small) member 8" Q9UJY1 12 119171555-119224855 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Stress response" Chaperone "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 897.3" "Group enriched" "Detected in many" 6 "Cardiomyocytes: 599.1;Syncytiotrophoblasts: 1340.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "EFO-21: 89.6;HeLa: 66.0;MCF7: 130.5;U-87 MG: 67.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015876 Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 80: Striated muscle - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Cytosol Nucleoplasm "HPA015876: AB_1850458" "unprognostic (1.52e-2)" "unprognostic (6.97e-2)" "unprognostic (1.96e-2)" "unprognostic (1.42e-1)" "unprognostic (1.88e-1)" "unprognostic (1.99e-3)" "prognostic unfavorable (2.98e-4)" "unprognostic (2.47e-1)" "unprognostic (4.03e-2)" "unprognostic (7.91e-2)" "unprognostic (6.48e-3)" "unprognostic (1.11e-1)" "unprognostic (1.30e-1)" "unprognostic (2.05e-3)" "unprognostic (2.05e-1)" "unprognostic (6.36e-2)" "unprognostic (2.17e-2)" 57.0 13.9 172.2 34.4 172.6 0.0 33.4 179.5 141.8 58.1 147.0 381.0 8.9 114.4 10.1 163.2 58.7 43.1 469.3 147.8 231.0 63.3 4.8 95.7 11.4 188.3 206.1 23.4 30.8 183.1 17.5 92.1 193.0 143.5 35.8 28.2 50.8 289.0 897.3 70.5 50.5 114.1 211.5 56.2 110.4 12.0 193.6 40.3 29.2 448.5 98.7 239.2 100.1 235.5 21.1 16.1 0.3 0.0 14.4 11.5 60.2 32.5 28.7 5.9 0.3 40.0 0.6 0.1 89.6 42.4 48.0 2.4 0.3 0.0 0.6 0.1 1.2 0.0 66.0 3.2 11.2 0.0 0.1 14.1 4.1 22.3 1.3 21.6 12.3 0.0 0.2 0.0 13.0 130.5 0.0 0.2 5.7 0.0 23.0 0.0 22.9 2.9 38.3 6.2 0.4 1.0 13.5 1.6 6.8 50.5 29.0 0.2 20.4 15.8 39.8 21.7 1.7 0.0 0.2 0.2 67.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 172.2 172.6 179.5 141.8 147.8 231.0 188.3 206.1 193.0 211.5 193.6 235.5 2.7 44.8 48.2 42.1 0.7 102.3 108.5 4.5 126.3 0.7 95.2 17.5 599.1 7.2 5.4 5.5 8.4 149.1 1.0 0.0 0.0 59.7 12.2 98.1 20.2 27.4 0.0 0.0 6.2 11.4 17.5 82.2 5.6 142.7 1.3 0.0 25.4 0.0 19.4 1.7 6.6 0.0 2.0 1.0 9.4 11.0 1.5 1.6 12.4 2.8 1.0 51.7 0.0 0.0 0.9 12.9 0.0 0.4 0.3 24.6 0.0 52.0 3.1 2.1 6.6 39.8 76.9 0.9 0.2 38.0 28.7 1340.0 3.5 0.1 0.2 72.7 HSPD1 "GroEL, HSP60, SPG13" ENSG00000144381 "Heat shock protein family D (Hsp60) member 1" P10809 2 197486584-197516737 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Host-virus interaction" "Chaperone, Isomerase" "Cancer-related genes, Disease variant, Hereditary spastic paraplegia, Leukodystrophy, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 790.6" "Cell type enhanced" "Detected in all" "Basal prostatic cells: 1737.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001523, CAB002775, HPA050025, CAB072816" Supported Enhanced Mitochondria NA NA 18000000 "Cluster 39: Non-specific - mRNA processing" "Cluster 35: Non-specific - Unknown function" "Cluster 39: CACO-2 - Unknown function" "Cluster 22: Epithelial cell types - Mixed function" Mitochondria "CAB002775: , CAB072816: , HPA001523: AB_1079028, HPA050025: AB_2680995" "unprognostic (2.79e-2)" "unprognostic (1.72e-2)" "unprognostic (5.21e-2)" "prognostic unfavorable (1.61e-4)" "unprognostic (2.59e-1)" "unprognostic (3.57e-3)" "prognostic unfavorable (2.25e-4)" "unprognostic (3.51e-2)" "unprognostic (9.91e-2)" "unprognostic (8.63e-3)" "unprognostic (3.47e-2)" "unprognostic (7.83e-3)" "unprognostic (5.64e-3)" "unprognostic (1.73e-2)" "unprognostic (1.52e-1)" "unprognostic (2.61e-2)" "unprognostic (4.10e-2)" 179.4 790.6 188.6 128.3 191.6 110.6 168.8 204.9 401.9 96.9 217.8 170.0 158.1 90.8 89.3 124.5 132.6 69.1 145.0 184.3 198.6 374.9 462.6 136.6 149.2 199.6 198.5 167.6 219.0 159.2 116.0 148.6 205.3 104.5 195.1 71.8 93.9 93.6 162.7 83.3 148.7 104.5 195.1 94.6 155.4 57.6 198.6 99.3 138.7 176.7 172.7 144.6 92.3 201.4 559.7 650.1 541.3 496.9 373.6 389.2 786.5 573.2 304.7 686.1 495.6 2219.1 326.2 1724.4 730.0 304.1 834.2 538.4 2232.9 633.2 943.0 417.0 888.2 1209.8 984.8 2562.8 353.2 1331.4 349.1 445.5 717.1 599.5 1053.2 471.4 542.6 919.1 1535.3 606.8 501.7 690.4 853.6 1304.2 1086.4 735.2 1424.9 1000.1 679.7 1235.5 709.5 539.7 716.5 400.8 582.0 608.5 771.0 1116.3 425.0 789.4 242.2 405.8 570.4 532.8 910.0 331.1 861.4 1399.5 485.7 795.3 456.7 12.1 52.3 11.4 36.4 81.8 71.7 63.8 59.6 54.3 84.6 54.0 81.0 70.3 11.0 62.6 72.1 49.4 51.8 70.6 188.6 191.6 204.9 401.9 184.3 198.6 199.6 198.5 205.3 195.1 198.6 201.4 216.4 166.7 172.5 38.8 220.4 246.6 1737.2 247.5 264.0 75.8 216.0 263.1 239.2 195.9 287.9 79.1 256.5 825.7 197.7 213.7 375.6 235.0 6.2 322.2 304.5 233.9 274.6 241.6 31.9 145.9 419.8 356.0 215.6 445.2 299.5 407.1 63.1 312.5 328.0 95.9 47.2 302.2 166.8 88.6 479.3 12.8 130.5 381.9 163.7 30.0 138.5 125.7 68.0 20.6 35.6 171.4 163.2 113.6 322.9 705.9 160.1 797.1 328.6 117.1 85.5 199.0 471.7 88.5 106.0 262.4 207.1 1001.2 467.2 1017.4 512.1 861.5 HTRA1 "ARMD7, HtrA, IGFBP5-protease, PRSS11" ENSG00000166033 "HtrA serine peptidase 1" Q92743 10 122458551-122514907 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Growth factor binding, Hydrolase, Protease, Serine protease" "Age-related macular degeneration, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Fibroblasts: 269.3;Granulosa cells: 731.6;Horizontal cells: 625.9;Muller glia cells: 373.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 2417.8;ASC TERT1: 889.4;fHDF/TERT166: 862.3;HSkMC: 1581.4;LHCN-M2: 1238.2;U-87 MG: 1004.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036655 Approved Supported "Plasma membrane" "Secreted to blood" NA NA 24800000 7600000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 68: Epididymis - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 40: Granulosa cells - Unknown function" "Plasma membrane" "HPA036655: AB_10671966" "unprognostic (3.84e-1)" "unprognostic (3.42e-2)" "unprognostic (1.57e-2)" "unprognostic (1.86e-2)" "unprognostic (1.22e-3)" "unprognostic (8.71e-3)" "unprognostic (2.33e-2)" "unprognostic (3.83e-1)" "unprognostic (7.22e-2)" "unprognostic (3.36e-2)" "unprognostic (1.32e-1)" "unprognostic (1.54e-1)" "prognostic unfavorable (7.90e-7)" "unprognostic (7.12e-3)" "unprognostic (9.13e-2)" "unprognostic (1.69e-1)" "prognostic unfavorable (5.62e-6)" 246.0 81.3 382.1 37.0 436.6 0.5 202.8 422.6 595.7 352.1 316.2 154.8 20.8 197.1 247.1 57.8 122.9 301.2 114.7 377.7 411.4 230.9 226.4 69.9 39.9 427.1 447.0 425.5 55.9 111.8 184.1 281.9 425.3 85.7 51.8 243.6 101.1 114.5 31.1 130.5 73.5 152.3 382.1 54.2 87.3 19.5 423.6 21.2 78.8 80.9 27.3 137.3 188.3 464.2 0.3 45.6 19.4 5.7 2417.8 889.4 0.8 108.3 196.8 44.4 23.6 0.2 0.6 0.0 29.0 862.3 68.6 12.8 7.6 124.4 6.2 0.1 4.9 0.1 65.4 0.3 123.7 0.1 0.9 1581.4 444.6 25.8 205.3 503.6 207.1 0.0 0.1 1.5 1238.2 22.3 0.1 0.7 20.9 0.2 67.6 0.2 1.3 0.4 282.6 2.2 1.2 3.9 272.1 0.2 122.2 91.4 8.6 0.2 136.0 309.9 4.5 141.3 94.1 0.2 0.1 0.3 1004.6 0.2 148.5 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 382.1 436.6 422.6 595.7 377.7 411.4 427.1 447.0 425.3 382.1 423.6 464.2 55.1 22.4 6.9 116.5 0.9 44.1 32.5 10.8 23.9 53.3 5.4 31.2 26.4 14.3 0.9 64.4 54.2 30.9 1.3 0.0 0.0 2.0 3.5 11.3 76.5 107.0 0.0 2.7 2.2 4.6 164.6 269.3 4.6 14.4 1.3 731.6 57.8 157.8 51.3 625.9 31.2 0.3 8.2 18.1 59.9 4.2 31.7 22.0 46.2 86.2 8.5 373.8 0.0 193.0 112.5 2.7 1.3 77.5 1.9 8.7 0.2 22.6 10.1 150.3 6.6 63.3 140.5 0.2 0.7 7.0 30.5 87.7 7.2 2.5 0.6 11.9 HTRA2 "OMI, PARK13, PRSS25" ENSG00000115317 "HtrA serine peptidase 2" O43464 2 74529725-74533332 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins" Apoptosis "Hydrolase, Protease, Serine protease" "Disease variant, Epilepsy, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Erythroid cells: 118.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004004, HPA006602, HPA027366" Uncertain Supported Mitochondria NA NA 260000 "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 39: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 10: Non-specific - Unknown function" Mitochondria "CAB004004: AB_326421, HPA006602: AB_2667622, HPA027366: AB_1851301" "unprognostic (3.09e-1)" "unprognostic (4.06e-2)" "unprognostic (2.82e-1)" "unprognostic (2.58e-2)" "unprognostic (1.56e-1)" "unprognostic (1.37e-1)" "prognostic unfavorable (7.77e-8)" "unprognostic (2.12e-3)" "unprognostic (4.18e-1)" "unprognostic (1.15e-1)" "unprognostic (4.57e-2)" "unprognostic (8.15e-2)" "unprognostic (7.23e-3)" "unprognostic (4.03e-1)" "unprognostic (1.73e-1)" "unprognostic (1.72e-1)" "unprognostic (2.06e-2)" 11.4 8.6 8.1 8.1 8.7 11.1 6.8 9.1 9.7 7.1 7.7 6.4 6.9 6.9 1.0 6.0 7.1 4.7 9.4 8.1 8.3 8.1 6.5 6.6 7.8 8.6 8.5 10.9 7.4 9.4 4.7 6.3 8.3 4.8 3.3 2.5 8.5 5.3 14.5 5.4 7.9 5.3 8.2 9.9 6.4 6.2 9.6 9.1 6.8 9.0 4.8 6.5 5.8 9.2 19.1 14.7 14.7 12.6 21.3 9.0 30.1 17.0 10.3 10.3 7.0 21.1 8.5 16.6 12.9 10.7 26.0 19.7 12.0 19.6 2.4 34.0 31.4 33.3 10.8 19.0 19.8 15.3 22.4 9.9 13.7 18.4 19.5 18.4 14.2 23.5 43.9 24.9 9.7 14.1 22.0 31.1 10.0 22.8 37.7 15.8 37.0 17.1 9.6 8.2 15.1 17.7 8.9 18.6 32.5 7.3 9.3 13.2 10.6 19.2 19.7 33.4 35.3 29.5 10.2 9.8 13.6 23.4 13.0 5.8 7.0 4.0 4.8 5.7 5.8 11.0 4.8 4.1 8.6 9.9 4.3 4.1 2.6 5.0 4.5 4.5 5.7 5.5 8.1 8.7 9.1 9.7 8.1 8.3 8.6 8.5 8.3 8.2 9.6 9.2 30.7 0.0 4.8 6.2 27.3 20.6 19.7 33.8 13.6 12.0 17.4 21.7 0.9 21.5 15.7 11.0 0.0 24.7 25.8 12.5 35.2 32.4 30.8 11.9 18.1 29.6 9.0 118.5 6.3 17.7 37.8 23.3 11.2 12.9 27.3 20.9 22.9 12.7 31.5 10.1 6.3 12.3 20.3 10.7 19.4 48.9 24.8 14.6 30.2 2.8 26.3 20.2 30.9 5.5 7.5 26.1 16.8 20.7 36.0 21.3 24.8 36.8 13.5 16.3 26.3 18.7 56.5 64.3 43.3 16.7 22.0 20.2 20.6 27.1 20.0 15.7 HTT "HD, IT15" ENSG00000197386 Huntingtin P42858 4 3041363-3243960 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" Apoptosis "Disease variant, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 181.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002756, HPA026114" Uncertain Supported Nucleoplasm,Cytosol NA NA 36000 "Cluster 27: Non-specific - Gene expression" "Cluster 59: Non-specific - Translation" "Cluster 3: HMC-1 - Innate immune response" "Cluster 9: Photoreceptor cells - Phototransduction" Nucleoplasm Cytosol "CAB002756: , HPA026114: AB_1851330" "unprognostic (2.05e-1)" "unprognostic (1.09e-1)" "unprognostic (8.79e-3)" "unprognostic (1.08e-1)" "unprognostic (1.66e-1)" "prognostic favorable (3.26e-4)" "unprognostic (1.52e-2)" "unprognostic (8.33e-2)" "unprognostic (8.06e-2)" "unprognostic (2.15e-1)" "unprognostic (1.87e-2)" "unprognostic (6.04e-2)" "prognostic favorable (2.41e-12)" "unprognostic (9.46e-3)" "unprognostic (1.99e-1)" "unprognostic (6.53e-2)" "unprognostic (3.84e-2)" 8.3 9.3 10.5 8.2 11.7 8.1 7.6 7.8 14.2 6.1 8.2 8.1 6.0 7.1 8.3 10.4 6.7 5.1 7.1 15.7 3.5 7.9 8.9 10.1 11.5 8.7 5.2 7.2 21.3 12.3 9.0 6.9 7.8 7.0 6.5 10.3 7.2 5.8 15.3 15.1 9.7 5.8 3.0 11.5 8.9 10.1 6.8 11.3 9.1 12.4 8.8 7.3 7.0 11.0 19.5 14.2 17.6 10.3 30.9 20.2 17.7 9.0 10.4 13.0 12.6 17.3 12.2 28.6 8.9 20.9 21.6 10.7 20.6 15.3 12.0 7.8 15.4 27.4 18.0 18.8 7.5 17.7 37.9 11.1 9.5 25.4 10.7 9.3 14.3 13.0 17.7 9.9 11.4 17.9 22.4 17.1 21.2 9.7 20.7 17.7 16.9 5.7 14.2 18.1 18.5 13.9 15.0 5.7 14.6 12.9 16.1 10.8 20.6 16.8 11.1 12.4 19.0 7.6 8.8 22.9 13.4 16.4 13.3 0.0 0.7 0.9 1.0 1.1 0.7 0.8 0.8 1.3 1.1 0.6 0.4 0.7 0.1 0.9 1.5 0.7 1.2 0.7 10.5 11.7 7.8 14.2 15.7 3.5 8.7 5.2 7.8 3.0 6.8 11.0 15.8 25.6 14.8 41.1 20.7 13.8 8.0 12.4 9.1 48.1 20.4 15.4 10.4 17.2 14.6 14.7 181.4 11.8 26.1 22.4 5.9 12.0 9.4 23.1 20.8 17.2 18.5 18.5 88.8 17.5 11.7 13.9 20.9 25.3 11.4 54.9 22.1 17.1 26.7 45.4 75.1 13.3 4.1 23.4 15.4 10.3 16.1 25.4 8.8 40.3 18.2 20.8 24.7 59.8 52.4 20.0 21.2 11.7 15.3 15.7 20.9 12.2 12.0 50.7 13.1 19.2 13.6 13.0 21.3 21.9 20.0 8.3 19.5 16.8 20.9 11.6 IBA57 "C1orf69, FLJ12734" ENSG00000181873 "Iron-sulfur cluster assembly factor IBA57" Q5T440 1 228165804-228182257 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Heme biosynthesis" Transferase "Disease variant, Hereditary spastic paraplegia, Neurodegeneration, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Erythroid cells: 49.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030555, HPA030556, HPA030557" Approved Supported Mitochondria NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 39: Non-specific - Mitochondria" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 6: Erythroid cells - Oxygen transport" Mitochondria "HPA030555: AB_2673522, HPA030556: AB_2673523, HPA030557: AB_10670433" "unprognostic (3.00e-2)" "unprognostic (1.71e-1)" "unprognostic (1.36e-1)" "unprognostic (1.29e-2)" "unprognostic (1.34e-1)" "unprognostic (8.16e-3)" "unprognostic (1.03e-1)" "unprognostic (6.11e-2)" "unprognostic (7.01e-2)" "unprognostic (8.00e-3)" "unprognostic (2.87e-2)" "unprognostic (1.61e-1)" "prognostic favorable (1.71e-9)" "unprognostic (4.94e-2)" "unprognostic (5.02e-1)" "unprognostic (5.04e-3)" "unprognostic (7.14e-2)" 2.0 2.7 2.6 1.4 2.3 4.1 1.4 2.9 2.5 1.3 2.2 1.8 1.6 1.8 0.5 1.6 1.3 1.0 3.3 2.1 2.0 2.0 2.8 1.9 1.6 2.7 2.2 1.9 2.9 2.1 0.9 1.4 2.3 1.2 1.4 0.5 1.7 1.0 6.1 3.0 1.7 1.7 2.1 1.7 2.0 1.1 2.8 1.3 1.3 4.0 1.7 1.3 1.2 3.5 2.5 2.5 2.7 1.2 1.3 1.4 3.3 1.5 0.7 1.1 0.6 5.3 2.1 5.3 3.1 1.6 0.6 4.4 2.0 3.2 1.0 1.1 4.5 3.1 3.5 2.6 1.1 3.7 3.5 2.2 1.8 1.3 1.5 1.0 1.6 3.2 5.4 2.4 1.1 2.0 3.6 2.2 2.0 3.4 2.8 4.4 3.1 2.4 1.6 5.1 4.1 2.8 2.4 7.5 1.9 0.5 6.0 4.9 3.8 3.0 2.8 2.1 3.7 1.8 0.9 2.6 1.4 1.6 2.3 1.6 0.4 0.2 0.6 0.4 1.0 0.4 0.5 0.5 0.3 0.7 0.7 0.7 0.5 0.8 0.4 1.0 0.5 0.2 2.6 2.3 2.9 2.5 2.1 2.0 2.7 2.2 2.3 2.1 2.8 3.5 5.7 9.6 11.0 4.2 10.2 8.2 8.8 3.9 2.8 5.8 5.6 5.6 15.3 8.6 9.2 0.0 12.5 10.7 5.0 14.5 7.9 5.4 22.2 5.2 6.0 8.8 7.2 49.3 3.8 6.9 8.6 5.2 5.1 10.3 15.2 6.7 5.3 7.9 5.5 3.3 4.1 8.0 4.1 4.4 6.4 30.7 3.7 6.0 7.2 6.5 4.2 4.4 4.1 3.0 5.8 8.8 6.3 7.2 5.8 6.3 9.4 6.7 3.2 19.5 6.6 9.7 4.7 14.9 11.2 4.4 6.0 16.3 7.2 8.3 11.9 8.3 IDH3A ENSG00000166411 "Isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha" P50213 15 78131498-78171945 "Citric acid cycle related proteins, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Tricarboxylic acid cycle" Oxidoreductase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "tongue: 99.7" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "plasmacytoid DC: 144.4" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041465, HPA062971" Supported Enhanced Mitochondria No No 110000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Mitochondria "HPA041465: AB_10794377, HPA062971: AB_2684913" "unprognostic (2.33e-1)" "unprognostic (1.21e-1)" "unprognostic (5.76e-3)" "unprognostic (2.26e-1)" "unprognostic (1.02e-1)" "unprognostic (4.01e-1)" "unprognostic (2.29e-1)" "unprognostic (6.47e-2)" "unprognostic (1.69e-2)" "unprognostic (2.30e-1)" "unprognostic (3.05e-1)" "unprognostic (1.42e-1)" "prognostic favorable (6.49e-8)" "unprognostic (1.40e-1)" "unprognostic (3.08e-2)" "unprognostic (4.49e-2)" "unprognostic (3.39e-2)" 22.6 25.1 11.5 19.9 12.6 9.7 9.6 17.0 14.7 12.4 21.4 26.2 36.6 13.7 7.8 17.0 11.0 9.0 62.5 14.8 13.2 16.8 14.2 11.9 17.1 13.0 13.1 10.8 13.0 54.7 6.9 12.1 15.2 13.9 26.7 26.2 16.2 16.1 79.4 15.8 36.0 17.1 10.1 15.3 11.9 16.9 14.3 35.0 11.2 99.7 24.8 17.7 11.1 14.8 43.8 58.5 10.4 36.5 25.5 26.1 22.6 50.8 24.5 40.6 30.5 41.6 25.8 91.6 36.8 29.9 59.9 64.2 98.2 39.3 37.0 40.7 32.2 35.7 62.4 19.2 21.8 69.8 48.8 19.9 23.6 39.4 41.2 19.3 25.7 32.0 46.4 35.9 26.0 41.4 51.4 17.4 12.9 25.2 21.8 29.3 44.4 28.1 33.4 58.3 41.4 15.8 58.2 82.1 47.1 19.1 32.7 37.4 26.4 47.6 43.9 63.1 83.1 41.5 99.9 48.8 33.2 64.9 37.7 16.9 27.9 8.3 15.1 52.9 16.4 27.7 14.7 13.5 43.5 32.6 15.2 16.4 15.5 17.3 54.8 144.4 17.7 23.2 11.5 12.6 17.0 14.7 14.8 13.2 13.0 13.1 15.2 10.1 14.3 14.8 18.0 9.6 16.5 22.9 30.6 56.0 58.7 51.4 33.0 35.1 10.9 12.6 17.5 14.3 22.6 25.8 37.5 38.3 63.0 69.0 82.2 26.1 52.2 19.9 13.4 17.5 19.2 9.4 45.9 17.9 40.4 21.2 11.7 9.2 27.3 14.5 10.8 22.4 26.5 26.9 53.3 37.6 69.2 24.9 28.6 23.4 20.8 26.4 26.6 12.2 16.0 29.3 12.3 19.6 17.9 21.5 37.9 23.7 33.2 40.6 49.6 48.1 38.2 34.6 13.1 23.8 25.5 45.7 26.2 28.4 41.2 68.4 17.7 37.2 56.0 42.0 IDH3B RP46 ENSG00000101365 "Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta" O43837 20 2658395-2664219 "Citric acid cycle related proteins, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Tricarboxylic acid cycle" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA049387, HPA054180" Supported Enhanced Mitochondria NA NA 8300 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 8: Non-specific - Mitochondria" "Cluster 39: CACO-2 - Unknown function" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "HPA049387: AB_2680740, HPA054180: AB_2682407" "unprognostic (1.19e-1)" "unprognostic (1.47e-1)" "unprognostic (2.12e-1)" "unprognostic (2.43e-2)" "unprognostic (3.24e-2)" "unprognostic (6.83e-2)" "prognostic unfavorable (1.59e-4)" "unprognostic (2.76e-2)" "unprognostic (2.99e-1)" "unprognostic (5.69e-2)" "unprognostic (4.75e-3)" "unprognostic (1.39e-2)" "prognostic favorable (6.78e-8)" "unprognostic (8.89e-2)" "unprognostic (4.02e-2)" "unprognostic (2.79e-1)" "unprognostic (1.16e-1)" 55.6 61.3 51.8 33.4 53.0 57.9 54.7 60.8 57.9 56.6 49.4 70.8 73.9 57.3 35.9 62.4 49.8 29.6 185.8 53.8 56.3 71.0 60.5 43.9 41.9 58.0 54.0 57.7 46.0 75.3 36.8 41.1 60.0 45.7 59.7 46.1 49.1 43.1 204.0 61.9 59.9 44.7 50.6 53.1 63.7 36.6 56.6 59.5 49.4 236.6 56.5 55.5 53.4 56.0 111.6 147.4 66.0 57.9 71.3 55.9 76.0 58.2 74.0 134.5 106.7 191.4 113.4 124.5 52.2 80.4 123.7 152.7 122.9 189.0 122.6 34.7 96.7 151.2 58.4 200.6 69.7 166.5 31.8 74.4 71.5 125.9 65.7 59.2 80.4 105.6 194.9 67.7 83.0 61.1 146.1 190.4 128.3 113.4 137.9 117.7 120.2 140.2 77.7 102.5 118.5 85.5 71.9 235.0 127.3 50.8 118.1 73.0 72.4 104.2 65.4 35.8 136.3 91.2 225.3 129.8 49.1 169.9 101.2 76.0 111.7 72.2 84.9 120.8 64.5 96.3 72.8 77.7 131.9 84.6 84.6 73.1 31.4 84.8 110.9 61.2 108.1 102.1 51.8 53.0 60.8 57.9 53.8 56.3 58.0 54.0 60.0 50.6 56.6 56.0 50.7 38.5 28.2 10.4 52.1 56.7 60.2 103.8 48.9 37.9 38.5 38.2 186.0 52.9 49.5 23.9 33.3 133.9 71.3 81.7 156.5 88.5 59.3 28.2 36.0 53.7 50.7 41.6 7.0 102.1 86.3 49.2 37.2 35.9 48.2 54.1 41.7 55.4 97.6 13.5 7.6 68.4 71.2 57.7 60.9 115.1 45.1 51.7 69.4 10.3 78.7 49.3 56.7 6.6 8.9 70.8 72.5 47.4 38.1 37.5 121.7 174.9 33.4 33.4 78.9 50.0 64.1 52.8 55.3 48.4 60.0 108.5 49.1 63.4 113.7 54.3 IFT140 "gs114, KIAA0590, WDTC2" ENSG00000187535 "Intraflagellar transport 140" Q96RY7 16 1510427-1612072 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cilium biogenesis/degradation" "Ciliopathy, Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 27.8;Late spermatids: 25.6;Respiratory ciliated cells: 31.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "MAIT T-cell: 3.7" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042197 Approved NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 6: T47d - Mammary gland" "Cluster 49: Ciliated cells - Cilium organization" "HPA042197: AB_2677895" "unprognostic (1.53e-1)" "unprognostic (1.53e-1)" "unprognostic (1.30e-1)" "unprognostic (5.21e-3)" "unprognostic (2.27e-1)" "unprognostic (2.87e-2)" "unprognostic (5.27e-3)" "unprognostic (3.28e-2)" "unprognostic (2.63e-1)" "unprognostic (4.35e-3)" "unprognostic (1.08e-1)" "unprognostic (1.52e-1)" "unprognostic (2.77e-2)" "unprognostic (7.55e-2)" "unprognostic (8.95e-2)" "unprognostic (2.91e-3)" "unprognostic (6.22e-3)" 5.5 8.9 10.1 2.2 10.3 1.8 7.0 10.5 13.2 11.3 20.8 7.4 3.4 9.6 4.9 4.1 15.3 5.3 4.9 9.8 11.8 10.4 3.8 8.7 2.4 10.2 14.8 12.6 7.7 8.4 15.7 3.1 9.8 9.5 1.3 6.4 6.0 5.3 2.7 5.6 4.8 2.5 10.2 4.1 6.8 15.3 11.6 3.2 22.9 1.0 1.1 12.0 7.2 8.3 2.0 12.4 9.5 9.6 8.0 5.9 5.4 2.6 9.5 2.7 3.3 3.4 9.9 3.8 7.3 3.9 3.6 7.5 1.7 1.5 1.9 3.3 7.6 2.3 9.3 8.3 6.9 1.3 4.7 8.4 5.9 3.2 4.2 10.5 2.0 7.6 2.6 2.2 2.1 12.0 6.9 3.9 10.4 2.5 2.9 6.3 3.4 5.7 8.3 6.2 18.0 10.0 2.9 5.0 3.9 5.1 17.4 5.1 3.9 2.2 7.0 4.0 1.1 6.8 2.6 2.4 3.7 0.8 2.9 0.0 0.4 0.2 0.4 0.2 3.7 0.6 0.6 1.4 0.6 0.2 1.9 3.0 0.0 1.1 0.3 0.5 0.1 0.8 10.1 10.3 10.5 13.2 9.8 11.8 10.2 14.8 9.8 10.2 11.6 8.3 2.9 12.8 11.5 19.9 1.2 1.7 2.9 4.0 4.6 3.7 6.8 6.0 4.0 5.7 6.1 11.0 25.0 7.8 2.2 2.1 1.9 3.2 21.7 27.8 5.9 2.1 5.4 2.5 12.7 1.0 1.3 4.5 7.1 6.2 1.3 11.5 2.2 0.9 2.3 8.4 12.4 6.1 8.2 0.6 0.7 25.6 4.7 1.4 0.0 13.1 0.4 5.6 0.0 6.6 4.9 2.1 1.5 4.1 0.7 1.4 1.0 3.5 31.2 17.2 0.0 3.1 3.0 20.9 7.5 2.0 1.1 2.2 1.6 6.2 3.5 1.5 IFT172 "BBS20, NPHP17, osm-1, SLB, wim" ENSG00000138002 "Intraflagellar transport 172" Q9UG01 2 27444377-27489805 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Developmental protein" "Ciliopathy, Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 439.9;Late spermatids: 703.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044893 Uncertain NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 36: HEL - Hemostasis" "Cluster 34: Spermatids - Unknown function" "HPA044893: AB_10795009" "unprognostic (1.05e-3)" "unprognostic (6.52e-2)" "unprognostic (7.04e-2)" "unprognostic (3.57e-3)" "unprognostic (1.95e-1)" "unprognostic (1.29e-2)" "prognostic unfavorable (6.05e-6)" "unprognostic (6.86e-3)" "unprognostic (1.45e-1)" "unprognostic (8.49e-2)" "unprognostic (1.08e-1)" "unprognostic (1.51e-2)" "unprognostic (4.32e-2)" "unprognostic (9.52e-2)" "unprognostic (5.49e-2)" "unprognostic (1.19e-1)" "unprognostic (5.47e-2)" 3.1 3.3 2.2 2.5 2.6 1.8 4.0 2.5 2.4 5.2 11.8 4.6 1.8 4.5 1.6 2.4 17.0 3.2 4.3 2.3 2.8 4.5 1.5 4.9 2.0 3.6 3.6 8.9 4.8 13.0 9.9 2.4 3.5 3.6 2.1 5.7 4.2 4.2 3.6 2.9 2.7 3.8 2.4 3.9 3.5 12.5 2.4 2.7 5.9 3.9 2.1 3.6 3.4 3.7 5.8 5.3 7.1 10.0 12.6 10.6 4.5 5.5 4.0 6.5 5.5 4.8 4.6 6.3 8.3 7.3 3.9 6.4 13.4 6.7 6.2 3.1 9.4 16.1 9.4 5.6 7.3 7.8 3.4 8.6 3.0 10.3 3.8 9.0 10.8 7.3 5.3 2.2 2.4 4.5 4.4 3.8 5.0 4.6 5.5 0.0 3.7 3.5 5.0 3.7 5.5 8.8 2.8 4.8 9.7 6.0 4.8 4.6 11.6 2.9 1.7 3.7 8.3 2.8 1.7 6.7 11.9 2.3 5.7 0.0 0.4 0.3 0.4 0.6 0.3 0.7 0.2 0.4 0.9 0.5 0.3 0.3 0.0 0.9 0.1 0.4 0.2 0.4 2.2 2.6 2.5 2.4 2.3 2.8 3.6 3.6 3.5 2.4 2.4 3.7 5.2 3.2 9.4 53.5 3.1 2.0 16.6 35.3 8.6 15.4 17.2 12.1 6.3 38.6 32.7 23.9 52.1 1.0 1.7 82.4 0.0 34.4 439.9 59.0 7.1 4.5 34.7 7.6 63.2 98.7 0.6 5.9 23.9 14.2 0.0 11.0 5.7 1.2 1.7 5.0 64.3 96.4 57.0 3.2 1.6 703.6 12.8 2.8 5.4 11.2 1.9 7.1 5.2 24.6 44.9 104.9 106.3 10.9 2.4 7.5 142.0 2.3 154.6 41.7 0.0 11.7 8.5 22.6 6.6 10.1 1.4 0.4 2.8 10.1 75.1 39.8 IFT43 "C14orf179, FLJ32173, MGC16028" ENSG00000119650 "Intraflagellar transport 43" Q96FT9 14 75902136-76084585 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cilium biogenesis/degradation" "Ciliopathy, Disease variant, Ectodermal dysplasia, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Respiratory ciliated cells: 305.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003438 Approved Supported "Microtubules,Centriolar satellite" NA NA "Cluster 37: B-cells - Transcription" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 6: T47d - Mammary gland" "Cluster 49: Ciliated cells - Cilium organization" Microtubules "Centriolar satellite" "HPA003438: AB_1078327" "unprognostic (1.64e-2)" "unprognostic (5.75e-3)" "unprognostic (2.10e-1)" "unprognostic (1.81e-3)" "unprognostic (1.48e-1)" "unprognostic (8.73e-2)" "unprognostic (1.53e-2)" "unprognostic (5.27e-2)" "unprognostic (8.87e-2)" "unprognostic (1.26e-2)" "unprognostic (2.32e-2)" "unprognostic (9.78e-2)" "unprognostic (4.43e-2)" "unprognostic (2.51e-1)" "unprognostic (2.70e-2)" "unprognostic (1.75e-1)" "unprognostic (1.07e-2)" 21.5 24.0 29.2 12.2 29.5 5.4 25.1 28.9 31.4 24.6 38.7 27.5 23.0 24.6 49.6 18.0 64.5 18.2 43.2 28.7 29.7 38.9 41.5 20.6 11.6 29.5 31.2 16.2 22.6 27.1 32.8 21.5 30.9 26.9 19.4 25.1 16.1 30.5 13.9 15.4 19.3 27.7 29.8 15.5 21.6 40.5 29.4 15.9 33.0 8.8 17.0 25.5 18.4 29.8 34.8 38.2 27.5 42.7 33.9 54.3 19.5 22.3 42.7 33.6 33.5 14.6 34.9 3.9 23.8 39.5 30.4 36.2 26.7 41.3 37.6 18.3 25.6 1.8 22.3 0.1 94.9 3.8 8.0 48.6 44.4 37.1 48.3 48.6 52.1 38.5 9.6 15.2 40.8 69.7 14.3 6.0 14.2 42.7 48.9 9.1 22.2 10.9 77.0 30.0 26.7 31.9 43.9 29.8 31.5 36.9 77.4 10.2 24.3 19.7 24.7 28.9 19.6 20.1 18.8 4.4 76.9 1.6 20.6 34.5 11.6 19.7 13.8 16.4 17.6 33.8 14.9 14.4 15.7 23.1 24.3 23.4 5.8 15.4 16.4 20.2 19.6 13.4 29.2 29.5 28.9 31.4 28.7 29.7 29.5 31.2 30.9 29.8 29.4 29.8 40.9 12.8 27.4 50.3 14.8 18.6 44.1 103.7 38.1 27.8 36.0 45.6 43.8 42.9 66.1 64.4 66.7 41.9 8.7 24.7 64.6 53.8 147.5 171.0 54.5 35.3 15.7 5.9 46.4 38.7 14.7 39.4 38.2 33.2 26.6 28.7 38.6 32.9 22.4 10.1 55.0 30.2 61.1 7.6 20.0 33.2 33.8 11.5 26.6 14.0 32.0 49.8 14.4 38.2 38.5 33.5 18.7 35.0 13.7 25.8 45.1 160.2 305.8 87.7 32.9 31.2 63.5 124.4 37.2 24.6 21.6 41.9 16.2 32.8 26.1 34.5 IGHMBP2 "CATF1, CMT2S, HCSA, HMN6, SMARD1, SMUBP2, ZFAND7" ENSG00000132740 "Immunoglobulin mu DNA binding protein 2" P38935 11 68903863-68940602 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, DNA-binding, Helicase, Hydrolase, Ribonucleoprotein, RNA-binding, tRNA-binding" "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Early spermatids: 94.6;Late spermatids: 46.9;Spermatocytes: 51.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004092, HPA060994" Supported "Nucleoplasm,Nuclear bodies" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 71: Testis - DNA repair" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm "Nuclear bodies" "HPA004092: , HPA060994: AB_2684406" "unprognostic (1.17e-1)" "unprognostic (1.04e-1)" "unprognostic (7.17e-2)" "unprognostic (3.96e-1)" "unprognostic (1.54e-1)" "unprognostic (1.69e-1)" "unprognostic (3.59e-3)" "unprognostic (4.31e-2)" "unprognostic (3.81e-1)" "unprognostic (1.19e-1)" "prognostic favorable (5.89e-4)" "unprognostic (1.03e-1)" "prognostic unfavorable (1.29e-8)" "unprognostic (1.69e-1)" "unprognostic (3.73e-2)" "unprognostic (4.06e-2)" "unprognostic (2.18e-2)" 5.2 4.0 1.2 2.5 1.3 6.0 5.4 0.7 1.7 7.0 0.1 11.8 1.5 7.8 0.6 5.5 6.7 1.7 5.2 1.6 1.2 4.4 6.3 5.1 3.3 0.8 0.4 6.1 5.2 2.8 4.0 2.0 0.7 6.3 1.5 1.4 6.4 3.1 8.5 7.7 6.3 2.6 0.5 5.7 6.2 15.4 0.6 4.3 4.9 3.8 1.7 6.3 5.8 1.1 5.1 7.3 4.0 7.4 3.6 3.1 5.2 5.8 3.9 7.8 4.6 14.5 7.0 7.3 9.7 3.3 6.9 8.0 5.8 4.9 1.8 8.3 6.2 6.6 9.6 5.6 5.5 6.5 7.4 1.8 4.9 9.2 4.6 4.5 4.6 11.1 10.6 4.6 2.3 5.1 11.1 8.9 2.3 7.9 10.3 9.4 5.7 7.6 3.3 5.9 8.6 5.4 7.4 6.1 16.6 3.0 9.3 6.0 6.6 5.3 3.8 7.7 6.6 6.0 6.3 6.9 5.3 6.1 5.1 0.0 2.0 0.8 1.5 1.8 1.3 1.0 0.9 1.0 1.8 0.6 0.5 0.7 0.6 0.1 1.1 0.3 0.6 1.3 1.2 1.3 0.7 1.7 1.6 1.2 0.8 0.4 0.7 0.5 0.6 1.1 6.6 6.4 7.7 7.5 5.7 5.7 3.8 3.5 6.2 9.1 5.6 3.8 6.3 8.6 6.1 1.8 20.9 4.9 10.2 6.0 1.9 5.1 94.6 7.0 8.1 6.4 3.0 9.3 7.4 5.1 4.4 5.5 6.1 14.0 7.0 10.7 3.3 6.1 5.8 11.8 6.4 4.1 2.0 3.5 4.3 46.9 7.8 7.2 1.8 5.6 7.3 6.6 9.2 6.0 5.2 6.5 8.4 7.2 5.8 7.5 3.9 2.9 3.8 10.1 0.0 5.1 10.1 51.6 7.1 5.3 6.7 6.7 8.0 4.6 7.1 6.3 ILDR1 "DFNB42, MGC50831" ENSG00000145103 "Immunoglobulin like domain containing receptor 1" Q86SU0 3 121987323-122022247 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" Receptor "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "parathyroid gland: 15.7" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 12.8;Club cells: 14.7;Collecting duct cells: 20.2;Cytotrophoblasts: 16.6;Distal enterocytes: 17.5;Glandular and luminal cells: 13.5;Respiratory ciliated cells: 13.7" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Immune cell enhanced" "Detected in some" "memory B-cell: 1.7" "Lineage enriched" "Detected in single" 4 "B-cells: 1.7" "Cell line enhanced" "Detected in some" "CAPAN-2: 6.3;HDLM-2: 8.2;MCF7: 5.1;RT4: 7.5;T-47d: 5.3;U-266/70: 6.1" "Not detected" "Not detected" "Not detected" "Not detected" HPA018207 Approved "Intracellular and membrane" NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 37: Intestine - Unknown function" "Cluster 44: HDLM-2 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA018207: AB_1851742" "unprognostic (2.69e-1)" "unprognostic (1.28e-2)" "unprognostic (9.24e-2)" "unprognostic (4.46e-3)" "unprognostic (9.73e-2)" "unprognostic (1.24e-1)" "unprognostic (1.65e-2)" "unprognostic (2.80e-2)" "unprognostic (2.00e-1)" "unprognostic (2.04e-1)" "unprognostic (7.78e-2)" "unprognostic (2.37e-1)" "prognostic favorable (5.79e-9)" "unprognostic (1.44e-2)" "unprognostic (1.18e-1)" "unprognostic (3.25e-3)" "unprognostic (2.21e-2)" 0.0 0.7 0.2 1.3 0.1 0.3 2.9 0.2 0.3 11.7 0.1 8.2 3.3 1.0 12.8 3.8 5.1 3.3 0.0 0.1 0.0 6.5 0.2 2.9 1.1 0.1 0.1 0.0 6.7 15.7 2.4 1.8 0.1 6.9 7.2 0.2 8.0 10.6 0.1 1.2 2.4 0.3 0.0 0.6 0.8 0.6 0.1 0.8 7.3 0.0 2.2 2.2 1.1 0.1 2.9 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.2 6.3 1.1 0.0 0.0 0.0 1.0 0.0 0.0 0.0 8.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 5.1 0.0 0.1 0.0 1.2 0.0 0.0 0.0 2.4 2.8 7.5 0.2 0.0 0.0 0.7 0.0 0.1 5.3 0.0 0.0 0.0 0.0 0.0 0.0 6.1 1.4 1.1 0.0 0.1 0.0 0.2 0.2 0.0 0.0 0.1 0.0 1.7 0.0 0.0 0.2 1.1 0.1 0.0 0.2 0.0 0.0 0.0 0.4 0.1 0.2 0.1 0.2 0.3 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 12.8 7.4 0.3 1.3 0.0 0.8 7.5 0.0 0.0 4.2 2.4 0.7 4.3 14.7 20.2 0.0 16.6 0.1 17.5 1.9 7.5 0.2 6.3 1.6 0.1 3.5 0.0 0.5 3.7 0.5 0.1 1.1 13.5 0.0 0.2 0.0 0.1 1.2 0.0 0.5 7.9 8.2 0.6 0.0 0.0 0.0 0.3 1.8 1.9 0.0 0.0 0.0 0.0 0.2 2.6 8.9 0.0 2.1 2.2 2.5 2.1 13.7 0.0 0.0 0.0 0.6 0.0 0.1 5.9 0.6 5.1 0.1 0.0 7.8 3.5 IMPDH1 "LCA11, RP10, sWSS2608" ENSG00000106348 "Inosine monophosphate dehydrogenase 1" P20839 7 128392277-128410252 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "GMP biosynthesis, Purine biosynthesis" "DNA-binding, Oxidoreductase, RNA-binding" "Disease variant, FDA approved drug targets, Leber congenital amaurosis, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "retina: 106.2" "Cell type enhanced" "Detected in many" "Bipolar cells: 165.8;Cone photoreceptor cells: 141.8;Horizontal cells: 121.1;Rod photoreceptor cells: 205.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "classical monocyte: 89.1;eosinophil: 89.1;intermediate monocyte: 104.5;myeloid DC: 59.9;neutrophil: 197.5;non-classical monocyte: 135.9" "Group enriched" "Detected in all" 5 "dendritic cells: 59.9;granulocytes: 197.5;monocytes: 135.9" "Cell line enhanced" "Detected in all" "SK-BR-3: 374.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001400 Approved Supported "Cytosol,Rods & Rings" NA NA 17000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 79: Retina - Phototransduction" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 56: Bipolar cells - Visual perception" Cytosol "Rods & Rings" "HPA001400: AB_1079139" "unprognostic (2.84e-1)" "prognostic unfavorable (3.87e-4)" "unprognostic (2.23e-2)" "unprognostic (6.45e-2)" "prognostic unfavorable (7.31e-5)" "unprognostic (6.03e-2)" "prognostic unfavorable (1.12e-7)" "unprognostic (1.24e-1)" "unprognostic (7.45e-3)" "unprognostic (1.03e-2)" "unprognostic (1.79e-1)" "unprognostic (2.50e-1)" "prognostic unfavorable (1.78e-12)" "unprognostic (1.65e-1)" "unprognostic (1.19e-1)" "unprognostic (1.10e-1)" "prognostic unfavorable (3.72e-5)" 54.8 15.9 19.2 33.8 18.5 44.1 38.7 15.7 23.7 18.5 12.7 24.8 8.3 15.1 2.5 30.0 17.7 11.9 23.7 18.1 17.8 15.8 5.7 31.7 25.5 26.3 18.7 20.5 30.1 5.3 26.7 11.4 25.6 27.8 9.8 106.2 29.5 13.1 4.7 23.2 19.1 19.6 17.1 55.9 48.9 16.5 20.0 8.4 11.5 6.2 15.9 29.4 20.4 17.1 111.5 93.2 13.8 102.8 56.5 40.7 38.8 74.1 46.4 61.9 40.1 68.3 35.0 70.8 24.7 111.1 64.4 83.3 78.6 104.1 30.9 25.8 87.1 46.4 66.8 49.1 51.4 62.1 21.1 49.4 49.5 63.2 62.5 29.2 74.5 42.0 46.9 51.8 21.0 76.1 44.1 164.9 77.4 87.7 108.0 51.9 25.2 150.8 27.5 35.1 58.3 55.6 48.0 374.6 68.3 8.6 42.7 119.7 68.5 103.6 37.7 55.0 53.6 38.5 38.3 90.6 53.0 134.0 64.6 11.2 89.1 89.1 22.7 104.5 24.4 15.5 17.9 20.2 59.9 8.9 10.3 12.7 197.5 11.7 135.9 6.0 21.5 58.3 19.2 18.5 15.7 23.7 18.1 17.8 26.3 18.7 25.6 17.1 20.0 17.1 66.8 0.0 11.2 4.6 13.5 8.8 9.3 13.6 9.6 165.8 12.8 9.9 5.1 2.8 8.6 5.5 141.8 3.3 11.1 6.3 5.9 8.1 0.5 4.0 10.9 20.3 9.6 9.7 8.2 17.8 21.3 15.1 44.9 6.5 21.0 46.0 13.6 1.0 46.1 121.1 11.2 10.1 28.5 58.5 21.7 2.0 4.7 38.2 16.0 3.7 65.3 27.3 24.7 2.0 1.5 10.9 3.1 6.8 29.6 21.5 0.8 1.1 7.4 205.5 0.0 9.0 17.3 2.9 16.9 15.8 7.4 2.3 20.4 18.6 11.9 10.3 IMPG1 "GP147, IPM150, SPACR" ENSG00000112706 "Interphotoreceptor matrix proteoglycan 1" Q17R60 6 75921114-76072678 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" "Heparin-binding, Receptor" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 267 "retina: 670.7" "Group enriched" "Detected in some" 8 "Cone photoreceptor cells: 673.5;Rod photoreceptor cells: 694.9" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "HaCaT: 1.2" "Region enriched" "Detected in single" 4 "basal ganglia: 3.3" "Not detected" "Not detected" "HPA027142, HPA030332, HPA030333" Enhanced "Secreted in other tissues" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA027142: AB_2672132, HPA030332: AB_2673432, HPA030333: AB_2673433" "unprognostic (6.65e-2)" "unprognostic (4.13e-2)" "unprognostic (1.20e-1)" "unprognostic (8.69e-2)" "unprognostic (1.22e-1)" "unprognostic (5.49e-3)" "unprognostic (5.97e-2)" "unprognostic (3.56e-3)" "unprognostic (1.89e-2)" "unprognostic (2.20e-1)" "unprognostic (1.45e-1)" "unprognostic (1.12e-3)" "unprognostic (2.84e-1)" "unprognostic (1.73e-2)" "unprognostic (2.09e-1)" "unprognostic (6.01e-2)" "unprognostic (1.96e-2)" 0.3 0.1 0.5 0.0 2.5 0.0 0.5 1.0 1.4 0.3 0.8 0.3 1.0 0.2 0.0 0.2 0.1 0.4 0.2 0.5 0.4 0.6 0.2 0.6 0.1 0.6 0.6 0.1 1.8 0.0 0.3 0.2 0.6 0.2 0.0 670.7 0.5 0.0 0.2 1.4 0.8 0.0 0.1 0.2 0.3 0.3 0.6 0.1 0.4 0.0 0.0 0.2 0.3 1.6 0.6 0.0 0.8 0.0 0.0 0.1 0.4 0.2 0.0 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.4 0.2 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.3 0.0 0.5 0.1 0.1 0.0 0.0 0.7 0.1 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 2.5 1.0 1.4 0.5 0.4 0.6 0.6 0.6 0.1 0.6 1.6 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 53.2 0.0 0.0 0.2 0.0 0.0 0.0 673.5 0.2 0.0 0.0 3.9 0.0 1.9 0.2 0.0 3.0 0.0 0.0 1.6 0.0 9.4 0.1 0.0 1.1 0.0 0.0 0.0 0.0 0.2 30.3 0.9 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 85.0 0.0 0.5 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 694.9 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 IMPG2 "IPM200, RP56, SPACRCAN" ENSG00000081148 "Interphotoreceptor matrix proteoglycan 2" Q9BZV3 3 101222546-101320575 "Disease related genes, Human disease related genes, Predicted membrane proteins, Predicted secreted proteins" "Heparin-binding, Receptor" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 32 "retina: 305.4" "Group enriched" "Detected in some" 18 "Cone photoreceptor cells: 517.1;Rod photoreceptor cells: 329.1" "Cancer enriched" "Detected in single" 12 "ovarian cancer: 2.7" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA008779, HPA015907" Enhanced "Secreted in other tissues" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 9: Photoreceptor cells - Phototransduction" "HPA008779: AB_2668138, HPA015907: AB_2669323" "unprognostic (2.00e-1)" "unprognostic (4.91e-2)" "unprognostic (1.40e-1)" "unprognostic (9.58e-3)" "unprognostic (1.28e-1)" "unprognostic (4.80e-5)" "unprognostic (6.66e-4)" "unprognostic (1.85e-1)" "unprognostic (1.09e-1)" "unprognostic (6.59e-2)" "unprognostic (7.51e-3)" "unprognostic (1.28e-1)" "unprognostic (4.50e-9)" "unprognostic (7.12e-2)" "unprognostic (2.70e-1)" "unprognostic (2.81e-2)" "unprognostic (6.08e-2)" 0.1 0.1 0.2 0.2 0.2 0.1 0.1 0.1 0.3 0.1 1.7 0.1 0.0 0.1 0.1 0.0 9.6 0.1 0.1 0.2 1.1 0.3 0.0 0.0 0.2 0.9 0.3 0.1 0.1 0.0 0.1 0.0 1.1 0.1 0.1 305.4 0.1 0.0 0.1 0.1 0.1 0.1 0.2 0.2 0.1 0.1 0.3 0.2 0.0 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.2 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.3 0.2 0.1 0.0 0.0 0.1 0.3 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.2 0.0 0.0 0.1 0.1 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.1 0.3 0.2 1.1 0.9 0.3 1.1 0.2 0.3 0.2 0.3 0.0 0.0 5.9 0.4 0.1 0.0 0.1 0.0 22.8 0.1 0.5 0.6 0.0 0.1 0.0 517.1 0.0 0.3 0.0 1.9 0.1 0.3 0.7 0.5 2.4 0.0 0.0 7.5 0.0 0.0 0.3 0.0 0.5 0.0 0.2 0.0 0.1 0.1 13.5 14.0 0.0 0.0 0.3 0.0 0.0 0.6 0.3 0.0 4.7 1.2 23.4 0.0 8.5 2.6 0.1 0.0 0.7 0.6 0.1 0.0 0.0 0.5 329.1 0.0 0.6 0.3 0.1 0.3 0.0 0.3 0.0 0.2 1.2 0.0 0.0 INF2 "C14orf151, C14orf173, MGC13251" ENSG00000203485 "Inverted formin 2" Q27J81 14 104681146-104722535 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Actin-binding "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 229.3;Gastric mucus-secreting cells: 183.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "PC-3: 100.8" "Region enhanced" "Detected in all" "basal ganglia: 224.1" "Low region specificity" "Detected in all" HPA000724 Approved Approved "Nuclear bodies,Endoplasmic reticulum" NA NA 3000000 "Cluster 35: T-regs - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 28: BEWO - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Endoplasmic reticulum" "Nuclear bodies" "HPA000724: AB_1078325" "unprognostic (1.42e-1)" "unprognostic (9.18e-2)" "unprognostic (2.57e-2)" "unprognostic (1.00e-2)" "unprognostic (1.49e-2)" "unprognostic (5.90e-3)" "prognostic unfavorable (8.18e-4)" "unprognostic (1.13e-2)" "unprognostic (9.55e-2)" "unprognostic (1.18e-1)" "unprognostic (1.26e-2)" "unprognostic (1.36e-3)" "unprognostic (7.24e-2)" "unprognostic (4.01e-1)" "unprognostic (2.36e-1)" "unprognostic (5.80e-2)" "unprognostic (7.70e-2)" 42.8 21.4 14.0 8.4 29.6 7.5 35.2 18.3 29.5 28.7 1.4 40.4 21.2 24.3 2.3 20.4 20.9 8.9 24.1 14.7 14.7 27.3 30.2 34.3 6.9 30.7 25.5 13.6 15.7 2.0 8.3 11.7 27.5 23.2 4.7 3.3 17.9 7.5 13.7 26.9 31.7 4.4 12.2 31.4 34.7 32.2 26.3 2.1 20.8 1.5 3.4 30.2 28.5 71.2 26.3 92.1 9.9 16.0 7.6 12.2 84.2 49.0 14.5 21.9 14.0 35.5 40.2 3.7 46.6 17.9 17.0 43.3 9.4 22.7 9.5 18.5 26.6 22.0 59.9 23.9 16.5 6.8 21.0 11.4 14.5 15.8 6.8 15.0 24.1 9.1 10.7 10.5 18.0 30.0 10.2 17.9 17.1 18.3 100.8 29.8 19.2 9.4 12.6 38.0 20.5 12.8 26.4 36.7 11.7 8.0 8.0 4.9 49.9 29.4 22.1 45.7 22.5 6.9 3.7 3.7 41.2 12.1 25.1 0.5 2.1 0.1 0.9 0.7 0.7 1.6 3.2 0.6 2.4 1.5 2.5 1.6 1.6 1.2 0.1 5.1 4.0 3.2 14.0 29.6 18.3 29.5 14.7 14.7 30.7 25.5 27.5 12.2 26.3 71.2 48.8 64.1 13.4 10.1 22.5 22.7 17.5 19.0 17.1 0.3 16.5 14.6 14.3 28.6 15.0 3.7 0.0 54.8 5.2 229.3 5.9 24.1 1.2 7.8 8.6 29.8 17.4 17.2 16.7 25.5 87.8 17.9 183.0 18.2 14.7 8.4 25.4 29.8 32.6 0.0 1.9 86.2 12.2 21.8 35.6 2.1 5.6 25.5 8.8 20.6 14.0 55.3 1.0 11.1 89.6 58.1 110.7 4.5 7.8 26.6 90.4 7.3 9.4 2.0 32.9 5.7 36.1 1.1 4.5 8.5 18.8 31.6 9.3 12.9 66.9 38.2 ITM2B "BRI, BRI2, BRICD2B, E25B, E3-16" ENSG00000136156 "Integral membrane protein 2B" Q9Y287 13 48232612-48270357 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters" "Amyloidosis, Deafness, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 4375.2" "Lineage enriched" "Detected in all" 5 "granulocytes: 4375.2" "Cell line enhanced" "Detected in all" "HMC-1: 731.2;RPTEC TERT1: 1718.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029292, HPA071992" Enhanced Enhanced "Golgi apparatus,Vesicles" "Secreted to blood" NA NA 5800000 "Cluster 5: Granulocytes - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Golgi apparatus, Vesicles" "HPA029292: AB_10601917, HPA071992: AB_2686480" "unprognostic (4.66e-2)" "unprognostic (2.02e-1)" "unprognostic (1.03e-2)" "unprognostic (1.00e-1)" "unprognostic (4.41e-2)" "unprognostic (6.84e-2)" "unprognostic (2.52e-1)" "unprognostic (1.29e-1)" "unprognostic (9.88e-2)" "unprognostic (2.42e-1)" "unprognostic (5.89e-2)" "unprognostic (2.87e-2)" "prognostic favorable (3.73e-5)" "unprognostic (4.38e-2)" "unprognostic (4.09e-2)" "unprognostic (6.00e-2)" "unprognostic (1.22e-1)" 510.2 367.4 286.9 172.5 301.0 125.6 323.8 328.6 489.0 416.1 406.6 260.1 289.2 388.8 1171.8 399.9 305.4 257.5 381.0 320.1 339.2 1306.3 391.2 376.1 236.7 334.9 308.0 507.2 179.6 233.7 290.5 573.8 304.4 312.5 191.4 174.4 408.7 386.2 164.7 399.6 287.4 232.5 373.6 435.2 312.8 121.4 308.8 188.3 386.1 206.2 187.4 305.1 402.2 394.8 67.6 51.8 73.1 116.3 348.5 254.5 119.2 215.0 202.2 87.5 100.6 29.1 248.3 16.6 168.8 121.6 48.5 214.1 61.3 107.0 107.4 69.9 147.3 137.9 29.0 99.0 138.5 140.6 731.2 113.4 149.1 45.1 62.0 375.7 131.2 78.3 24.5 90.9 174.8 29.6 200.4 310.1 266.0 116.5 103.6 100.1 100.5 73.6 1718.9 268.6 26.2 119.5 154.5 110.2 111.0 306.0 74.0 119.4 180.5 62.9 73.8 95.7 85.4 72.9 59.6 2.5 78.0 75.3 155.3 3091.4 864.5 2737.9 387.4 661.3 512.5 235.3 523.1 476.4 428.9 245.3 551.3 466.8 4375.2 356.5 692.7 196.2 563.4 1723.5 286.9 301.0 328.6 489.0 320.1 339.2 334.9 308.0 304.4 373.6 308.8 394.8 1380.0 695.5 300.4 174.6 408.6 862.4 1661.1 2606.2 1006.2 653.1 460.1 573.5 384.8 722.0 1121.9 1991.8 187.7 1164.3 448.2 754.2 545.9 910.2 23.6 751.8 802.2 1166.2 283.3 307.0 114.2 682.9 2362.8 1334.0 302.8 1177.2 578.0 421.2 1319.7 557.3 2117.8 353.3 142.6 503.2 1129.1 1569.8 900.6 76.7 1867.0 1381.5 681.3 252.0 1415.7 1634.9 425.3 174.4 237.9 515.7 788.3 2011.6 445.4 922.5 1259.3 2748.9 795.6 219.4 1222.7 602.4 1022.9 143.6 256.4 1384.6 1149.6 1471.5 723.2 665.5 440.9 1613.4 ITPA "C20orf37, dJ794I6.3, HLC14-06-P" ENSG00000125877 "Inosine triphosphatase" Q9BY32 20 3208868-3223870 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Nucleotide metabolism" Hydrolase "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022824, HPA073963" Approved Supported Nucleoplasm,Cytosol NA NA 120000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 37: Intestine - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Cytosol" "HPA022824: AB_1851960, HPA073963: " "unprognostic (1.58e-2)" "unprognostic (1.98e-1)" "unprognostic (1.73e-1)" "unprognostic (3.57e-1)" "unprognostic (4.63e-2)" "unprognostic (1.53e-2)" "prognostic unfavorable (2.54e-5)" "unprognostic (1.11e-2)" "unprognostic (1.68e-1)" "unprognostic (1.76e-1)" "unprognostic (1.83e-1)" "unprognostic (2.28e-1)" "unprognostic (1.94e-2)" "unprognostic (8.34e-2)" "unprognostic (3.63e-1)" "unprognostic (1.24e-1)" "unprognostic (1.84e-1)" 26.2 37.1 16.7 21.2 17.5 26.4 25.0 16.9 20.0 24.8 18.2 25.3 27.0 24.0 13.0 43.9 29.9 16.7 20.8 18.2 16.8 34.2 28.2 22.4 27.6 17.0 16.5 21.2 21.9 24.2 13.0 19.8 17.0 20.3 19.2 6.9 26.4 16.1 26.5 33.6 23.2 18.5 17.3 27.0 27.1 12.3 18.0 24.8 33.5 15.1 21.4 24.1 25.7 18.5 118.2 91.1 44.0 49.1 29.7 42.7 30.9 50.9 72.4 65.9 58.8 75.0 106.6 52.5 46.9 48.7 65.7 101.9 62.3 79.8 46.6 32.9 91.6 123.9 39.1 117.6 55.5 54.5 41.4 41.5 60.3 64.4 40.9 28.6 52.5 39.5 88.7 34.2 62.6 55.2 66.0 156.5 77.2 132.1 89.6 61.4 60.7 135.0 96.7 39.2 67.4 80.9 41.4 154.0 106.3 19.3 60.1 94.2 37.9 76.5 42.4 51.7 116.0 52.0 68.4 94.2 32.9 102.8 83.0 32.8 61.5 22.9 47.7 78.2 41.7 48.9 43.6 49.0 74.5 50.2 32.4 39.5 3.4 64.5 56.9 70.7 61.0 48.0 16.7 17.5 16.9 20.0 18.2 16.8 17.0 16.5 17.0 17.3 18.0 18.5 29.4 22.4 47.0 15.3 38.0 40.1 50.5 93.2 56.9 20.4 48.8 58.3 9.8 34.3 59.3 44.1 14.6 74.4 45.9 37.5 58.7 104.2 2.7 51.8 64.4 29.4 27.5 24.6 12.0 105.1 128.2 41.8 48.4 60.9 42.5 49.7 29.3 32.1 116.6 5.0 9.2 53.1 54.9 42.4 54.0 3.7 31.1 49.0 40.9 5.6 90.3 21.0 41.2 14.1 21.5 102.2 59.9 22.2 34.5 53.5 51.6 94.5 37.9 24.5 19.7 35.4 45.0 16.8 17.6 58.8 49.2 56.2 47.2 53.3 79.9 66.0 ITPR1 "ACV, Insp3r1, IP3R1, PPP1R94, SCA15, SCA16, SCA29" ENSG00000150995 "Inositol 1,4,5-trisphosphate receptor type 1" Q14643 3 4493345-4847840 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Apoptosis, Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel, Ligand-gated ion channel, Receptor" "Disease variant, Mental retardation, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 290.2;Inhibitory neurons: 183.1;Microglial cells: 84.3" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "cerebellum: 49.9" "Immune cell enhanced" "Detected in many" "naive B-cell: 13.4" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HDLM-2: 76.4;HEL: 41.1;HeLa: 74.9;HMC-1: 40.0;U-87 MG: 56.7" "Region enhanced" "Detected in all" "cerebellum: 697.2" "Region enhanced" "Detected in all" "cerebellum: 208.8" "HPA014765, HPA016487" Approved Approved Vesicles NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 89: Fibroblasts - ECM organization" "Cluster 44: HDLM-2 - Immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Vesicles "HPA014765: AB_1851843, HPA016487: AB_1851842" "unprognostic (1.92e-1)" "unprognostic (5.04e-2)" "unprognostic (1.34e-1)" "unprognostic (1.75e-1)" "unprognostic (2.16e-2)" "unprognostic (3.61e-2)" "unprognostic (1.60e-1)" "unprognostic (1.12e-1)" "unprognostic (1.12e-1)" "unprognostic (3.17e-2)" "unprognostic (1.92e-2)" "unprognostic (2.08e-1)" "unprognostic (2.77e-2)" "unprognostic (1.15e-1)" "unprognostic (1.09e-1)" "prognostic unfavorable (3.43e-4)" "unprognostic (2.40e-1)" 10.6 12.0 1.8 11.8 12.0 7.2 17.3 49.9 20.1 11.5 15.6 19.5 4.5 36.5 10.0 10.6 27.1 14.1 10.1 5.9 0.0 13.9 3.9 13.7 11.2 0.0 0.5 25.3 6.7 45.3 16.0 8.0 0.0 21.7 6.3 3.9 16.1 27.9 3.0 5.0 11.5 24.5 0.0 9.2 11.1 4.5 0.0 10.3 31.7 5.3 10.5 27.9 11.8 6.1 0.4 4.1 1.0 3.0 27.7 1.9 11.8 0.9 0.5 1.3 0.8 1.3 1.2 14.5 0.6 1.9 6.5 0.1 2.2 2.6 2.1 76.4 3.2 41.1 74.9 3.5 27.4 17.7 40.0 9.2 4.0 5.8 1.1 7.6 7.2 8.4 7.9 13.9 3.7 1.8 7.2 3.0 2.1 0.5 9.7 4.2 1.0 1.1 1.7 5.5 0.7 19.5 5.4 4.3 4.3 0.9 2.6 20.6 13.5 1.8 4.3 3.7 2.3 17.7 12.0 9.6 56.7 17.0 2.7 5.8 2.0 1.5 2.3 0.9 1.7 6.7 1.6 1.6 2.2 13.4 2.7 1.6 1.8 1.8 0.9 4.7 1.4 1.1 1.8 12.0 49.9 20.1 5.9 0.0 0.0 0.5 0.0 0.0 0.0 6.1 30.1 0.0 31.4 24.8 49.7 3.8 6.1 6.3 11.4 4.0 40.0 29.7 8.0 2.8 11.2 9.2 0.0 0.5 17.8 0.3 3.9 2.4 5.4 9.1 11.9 31.2 3.5 8.4 290.2 5.1 0.5 21.5 20.4 12.7 26.5 22.6 36.0 2.0 4.7 1.7 183.1 1.3 2.0 12.9 17.4 7.9 30.1 23.9 7.2 84.3 14.2 4.3 6.2 25.1 12.7 1.5 1.2 52.6 8.8 5.4 0.3 3.9 13.1 1.5 39.5 8.8 28.2 1.5 2.9 4.9 3.1 1.0 25.7 22.0 0.8 3.3 JAM2 "C21orf43, CD322, JAM-B, JAMB, VE-JAM" ENSG00000154721 "Junctional adhesion molecule 2" P57087 21 25639258-25717562 "CD markers, Disease related genes, Human disease related genes, Predicted membrane proteins" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 63.5" "Cell type enhanced" "Detected in many" "Adipocytes: 173.8;Astrocytes: 81.6;Endothelial cells: 148.7;Hepatic stellate cells: 112.8;Microglial cells: 82.4;Oligodendrocyte precursor cells: 76.9" "Cancer enriched" "Detected in all" 9 "glioma: 27.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 25.5;BJ hTERT+: 16.5;HDLM-2: 16.7;hTERT-RPE1: 22.5;U-138 MG: 18.1;U-87 MG: 13.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028789, HPA077346" Supported "Nucleoplasm,Plasma membrane" NA NA 360000 "Cluster 11: Basophils - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 12: NES - Nervous system development" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Plasma membrane" Nucleoplasm "HPA028789: AB_2732443, HPA077346: AB_2732341" "unprognostic (1.42e-1)" "unprognostic (6.39e-2)" "unprognostic (1.23e-1)" "unprognostic (1.73e-1)" "unprognostic (2.02e-2)" "unprognostic (1.53e-2)" "unprognostic (7.51e-4)" "unprognostic (2.61e-2)" "unprognostic (4.55e-1)" "unprognostic (1.02e-1)" "unprognostic (3.46e-2)" "unprognostic (3.81e-1)" "unprognostic (8.86e-2)" "unprognostic (5.71e-3)" "unprognostic (2.18e-1)" "unprognostic (2.20e-1)" "unprognostic (4.85e-3)" 20.5 15.8 16.6 3.7 21.5 0.3 16.8 24.0 21.8 16.8 12.8 17.8 6.1 18.5 11.2 7.1 16.1 12.9 19.2 19.2 22.0 9.2 2.2 15.5 3.6 25.9 23.1 16.1 2.8 4.3 8.1 63.5 21.3 9.4 7.9 7.1 6.1 15.4 7.8 5.5 10.7 19.6 26.8 1.6 10.2 17.6 25.2 2.6 10.3 13.2 5.0 11.6 13.2 23.0 0.0 0.0 25.5 0.1 1.0 0.2 0.5 0.8 16.5 2.0 7.6 0.0 0.0 0.1 0.0 0.2 9.7 0.1 2.2 0.0 4.6 16.7 0.7 0.1 0.1 0.1 0.0 0.1 0.1 1.4 0.0 1.8 0.1 22.5 0.0 0.6 0.0 0.2 8.0 0.0 0.4 0.1 8.1 0.2 0.0 3.2 5.3 0.1 0.0 0.0 0.4 3.7 0.2 0.3 0.0 0.3 0.9 0.2 0.0 18.1 1.7 0.1 2.5 1.8 0.1 0.0 13.4 0.1 0.7 0.4 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.6 0.1 0.2 0.4 0.6 0.1 0.4 0.0 0.1 16.6 21.5 24.0 21.8 19.2 22.0 25.9 23.1 21.3 26.8 25.2 23.0 173.8 0.0 2.3 81.6 0.9 7.5 1.4 0.0 2.2 1.4 1.4 9.1 33.2 0.0 0.0 3.7 14.6 0.3 0.5 0.0 0.0 0.2 16.5 1.0 4.7 148.7 0.0 0.0 15.2 0.2 5.3 28.5 0.5 2.1 0.0 4.5 112.8 0.5 1.3 0.0 45.0 0.0 0.0 1.8 10.7 15.6 9.9 2.8 16.0 82.4 0.0 1.8 0.0 76.9 4.1 0.1 0.0 24.5 1.2 1.5 0.0 0.0 0.7 5.2 0.0 5.7 7.0 6.7 4.4 0.8 6.7 0.8 1.6 2.1 0.0 1.2 JAM3 "JAM-C, JAMC" ENSG00000166086 "Junctional adhesion molecule 3" Q9BX67 11 134069071-134152001 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Angiogenesis, Cell adhesion, Differentiation, Spermatogenesis" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in many" 4 "Oligodendrocytes: 342.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "memory B-cell: 5.3" "Group enriched" "Detected in many" 7 "B-cells: 5.3;T-cells: 2.3" "Cell line enhanced" "Detected in many" "HUVEC TERT2: 99.5;RH-30: 122.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003417, HPA050434" Approved Enhanced "Golgi apparatus" "Secreted to blood" NA NA 44000 "Cluster 43: B-cells - Humoral immune response" "Cluster 57: Non-specific - Angiogenesis" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Golgi apparatus" "HPA003417: AB_1851981, HPA050434: AB_2681126" "unprognostic (1.04e-1)" "unprognostic (1.29e-1)" "unprognostic (1.38e-2)" "unprognostic (3.24e-1)" "unprognostic (1.60e-1)" "unprognostic (3.59e-1)" "unprognostic (1.32e-1)" "unprognostic (6.59e-2)" "unprognostic (1.13e-1)" "unprognostic (1.93e-1)" "unprognostic (5.06e-2)" "unprognostic (2.33e-1)" "prognostic unfavorable (3.73e-4)" "unprognostic (3.23e-3)" "unprognostic (2.17e-1)" "unprognostic (1.06e-3)" "prognostic unfavorable (2.68e-4)" 23.6 18.7 53.4 10.1 86.3 1.3 19.2 68.7 73.4 33.4 52.9 54.6 6.6 40.8 17.5 21.5 28.7 24.5 31.0 56.5 61.3 11.4 3.2 29.6 7.8 73.5 76.8 48.7 5.1 17.7 33.3 102.7 71.0 32.5 12.9 47.3 13.3 44.5 7.0 13.0 22.5 42.8 59.7 13.5 22.4 35.7 73.3 17.6 15.8 14.6 7.5 41.7 23.4 115.2 0.0 1.0 87.9 42.5 85.3 62.7 75.4 37.0 49.1 15.1 14.8 0.3 0.6 0.0 38.7 53.3 56.2 0.5 70.0 0.7 28.2 0.2 29.6 0.3 0.0 6.9 24.9 0.4 36.2 43.2 0.0 10.7 9.6 35.8 99.5 40.8 0.3 0.2 64.5 1.0 27.5 0.2 18.9 0.6 2.9 0.5 122.8 0.0 0.9 0.2 57.5 32.2 0.0 0.2 1.0 35.3 0.2 0.2 0.6 25.1 18.4 40.3 24.7 0.1 0.1 0.4 27.6 1.2 48.0 0.0 0.0 0.1 1.3 0.0 1.6 5.3 1.6 0.9 0.0 3.1 2.3 1.7 0.5 0.0 0.0 0.0 0.0 1.8 53.4 86.3 68.7 73.4 56.5 61.3 73.5 76.8 71.0 59.7 73.3 115.2 22.2 0.0 6.0 12.7 10.9 5.1 5.6 0.9 0.0 21.7 0.3 9.3 15.7 0.0 0.7 5.5 8.4 6.0 1.2 0.1 1.9 0.4 2.1 0.8 23.3 35.5 0.0 0.4 84.3 0.2 71.2 29.6 1.5 0.5 1.3 11.7 12.5 0.0 8.6 8.4 44.2 0.0 12.2 0.6 4.2 4.9 42.9 10.9 17.8 24.4 0.2 20.2 1.0 76.4 342.8 0.3 0.0 64.3 0.9 2.2 0.0 0.2 1.5 75.6 26.3 19.0 24.3 15.5 19.2 0.2 3.8 6.2 3.5 9.7 0.0 1.0 JPH1 JP-1 ENSG00000104369 "Junctophilin 1" Q9HDC5 8 74234700-74321540 "Human disease related genes, Predicted membrane proteins, Transporters" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 13 "skeletal muscle: 237.4;tongue: 106.0" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 38.5;Basal prostatic cells: 32.8;Cardiomyocytes: 35.7;Excitatory neurons: 82.2;Inhibitory neurons: 50.3;Prostatic glandular cells: 32.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "MOLT-4: 15.1;OE19: 17.7;SK-BR-3: 34.4;T-47d: 24.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA008996, HPA009413, CAB013461" Enhanced Enhanced Nucleoplasm NA NA "Cluster 33: Striated muscle - Muscle contraction" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm "CAB013461: , HPA008996: AB_1852023, HPA009413: AB_1079163" "unprognostic (2.91e-3)" "unprognostic (3.01e-1)" "unprognostic (8.85e-2)" "unprognostic (8.73e-6)" "unprognostic (2.07e-1)" "unprognostic (1.86e-1)" "unprognostic (3.63e-2)" "prognostic favorable (5.77e-5)" "unprognostic (8.97e-2)" "unprognostic (1.30e-1)" "unprognostic (2.38e-1)" "unprognostic (5.99e-2)" "unprognostic (9.80e-2)" "unprognostic (6.87e-2)" "unprognostic (3.03e-1)" "unprognostic (4.88e-2)" "unprognostic (1.08e-2)" 0.3 0.2 2.9 0.5 7.5 0.0 0.7 7.6 5.3 0.7 13.2 3.3 0.7 3.2 0.8 2.8 0.3 0.3 8.4 5.9 1.5 0.8 0.4 3.7 0.1 3.0 1.5 0.1 6.5 0.8 0.5 1.4 2.4 2.8 5.0 0.4 2.8 0.5 237.4 0.6 1.0 1.9 1.9 0.1 0.9 1.0 1.9 3.2 1.4 106.0 1.1 2.3 1.4 3.6 1.1 0.0 0.4 0.0 0.0 0.0 0.1 0.1 1.1 1.1 0.5 0.2 4.4 0.0 1.5 0.0 1.0 6.4 5.6 4.3 1.4 0.0 8.3 0.0 5.2 0.0 0.7 2.9 0.3 0.8 3.7 0.0 4.0 0.0 0.0 10.9 0.8 0.0 0.4 4.1 15.1 0.0 9.7 17.7 2.9 7.6 5.4 0.0 0.2 12.7 7.3 1.0 0.1 34.4 1.8 1.6 24.2 0.2 0.0 1.6 2.3 0.6 1.4 0.0 0.0 0.0 2.7 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.9 7.5 7.6 5.3 5.9 1.5 3.0 1.5 2.4 1.9 1.9 3.6 1.1 38.5 12.9 3.9 0.2 2.8 32.8 3.0 6.2 0.4 2.4 1.5 35.7 0.0 10.8 1.8 6.2 0.0 0.1 7.1 0.0 0.3 2.4 2.9 8.9 1.7 12.6 0.0 82.2 1.4 0.0 2.6 7.7 3.7 0.0 0.0 0.0 0.0 0.1 0.0 50.3 9.9 2.0 0.0 0.4 0.5 0.9 0.4 1.8 3.7 0.0 0.4 0.0 14.1 4.6 3.4 6.2 0.0 0.0 32.8 0.0 1.0 6.2 0.1 0.0 25.0 1.4 0.1 4.3 7.4 2.0 0.0 0.2 0.1 6.7 25.6 JPH3 "CAGL237, HDL2, JP-3, JP3, TNRC22" ENSG00000154118 "Junctophilin 3" Q8WXH2 16 87601835-87698156 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 4 "brain: 59.1" "Cell type enhanced" "Detected in some" "Bipolar cells: 24.4;Cone photoreceptor cells: 22.9;Early spermatids: 41.1;Excitatory neurons: 33.2;Horizontal cells: 50.5;Inhibitory neurons: 28.7;Late spermatids: 14.4" "Cancer enhanced" "Detected in some" "glioma: 1.7" "Group enriched" "Detected in all" 5 "amygdala: 17.1;basal ganglia: 24.6;cerebral cortex: 59.1;hippocampal formation: 42.7;white matter: 20.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "MCF7: 6.5;NTERA-2: 5.7;SH-SY5Y: 7.2;SiHa: 5.0;U-2 OS: 22.5" "Low region specificity" "Detected in all" HPA076304 Approved Nucleoplasm,Cytosol Yes No "Cluster 10: Brain - Neuronal signaling" "Cluster 9: U-2 OS - Unknown function" "Cluster 62: Horizontal cells - Visual perception" Nucleoplasm Cytosol "HPA076304: AB_2686793" "unprognostic (8.97e-3)" "unprognostic (3.17e-2)" "unprognostic (1.57e-3)" "unprognostic (4.82e-3)" "unprognostic (3.43e-1)" "unprognostic (9.12e-2)" "unprognostic (1.68e-2)" "unprognostic (8.10e-2)" "unprognostic (5.53e-2)" "unprognostic (1.48e-1)" "unprognostic (5.61e-3)" "unprognostic (2.80e-2)" "unprognostic (1.28e-4)" "unprognostic (3.01e-2)" "unprognostic (2.09e-1)" "unprognostic (1.87e-2)" "unprognostic (1.36e-2)" 0.2 1.3 17.1 0.2 24.6 0.0 0.1 1.1 59.1 0.7 0.0 1.1 0.1 0.2 0.0 0.6 0.4 0.0 0.1 42.7 5.6 0.0 0.1 0.1 0.0 6.4 5.8 0.1 0.3 0.0 14.1 0.0 1.1 0.2 0.0 1.8 0.0 0.3 0.0 0.1 0.5 0.0 1.1 0.1 0.5 1.4 1.1 0.0 0.1 0.0 0.0 0.1 0.3 20.6 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.3 0.0 0.1 3.0 0.0 0.9 0.0 1.2 0.0 0.0 0.1 0.9 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 6.5 0.0 0.0 5.7 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.5 7.2 5.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 22.5 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.1 24.6 1.1 59.1 42.7 5.6 6.4 5.8 1.1 1.1 1.1 20.6 0.0 0.0 0.0 2.3 0.1 0.0 0.2 0.0 0.0 24.4 0.0 0.0 3.7 0.0 0.0 0.0 22.9 0.0 0.0 0.1 0.0 0.0 41.1 0.0 0.0 0.8 0.0 0.0 33.2 0.0 0.0 0.1 0.0 0.1 0.0 0.0 2.2 0.0 0.1 50.5 28.7 0.0 0.0 0.0 0.0 14.4 0.3 0.0 0.0 0.0 0.0 1.3 0.0 10.6 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 9.6 0.0 0.2 0.1 1.1 3.7 0.0 0.0 0.1 0.1 0.5 0.0 0.1 KANK1 "ANKRD15, KANK, KIAA0172" ENSG00000107104 "KN motif and ankyrin repeat domains 1" Q14678 9 470291-746106 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 355.5;Late spermatids: 228.7;Oligodendrocyte precursor cells: 322.7;Oligodendrocytes: 191.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "plasmacytoid DC: 4.0" "Group enriched" "Detected in many" 15 "B-cells: 1.1;dendritic cells: 4.0;T-cells: 2.4" "Cell line enhanced" "Detected in many" "Hep G2: 96.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005539, HPA056090" Approved Supported "Plasma membrane" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 15: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 68: Oligodendrocytes - Mixed function" "Plasma membrane" "HPA005539: AB_1078164, HPA056090: AB_2683034" "unprognostic (6.59e-2)" "unprognostic (3.33e-2)" "unprognostic (1.06e-3)" "unprognostic (1.30e-1)" "unprognostic (2.69e-1)" "unprognostic (7.53e-2)" "unprognostic (3.33e-1)" "unprognostic (1.23e-2)" "unprognostic (4.91e-2)" "unprognostic (3.05e-2)" "unprognostic (2.84e-2)" "unprognostic (1.24e-1)" "unprognostic (3.07e-2)" "unprognostic (2.72e-1)" "unprognostic (3.06e-2)" "unprognostic (1.82e-1)" "unprognostic (1.61e-1)" 42.6 9.6 49.0 9.5 52.7 1.5 31.2 42.3 47.5 40.9 61.8 49.2 12.1 62.2 13.0 64.6 31.7 15.2 88.2 45.1 44.9 31.6 101.9 13.6 7.6 51.6 44.9 22.1 28.3 9.4 27.9 25.8 48.3 42.5 14.9 11.0 29.9 31.8 66.4 51.8 23.6 37.4 47.6 6.9 25.9 15.4 48.4 9.4 30.8 39.9 11.8 70.1 52.3 48.9 5.9 12.2 4.0 72.0 57.8 21.9 19.9 37.1 25.8 3.1 3.7 30.2 2.5 46.2 8.9 46.0 7.0 12.3 15.7 30.4 5.3 22.7 8.3 0.1 17.0 96.0 8.1 11.2 0.0 12.6 41.6 3.2 35.6 13.2 31.2 1.6 2.4 56.4 23.1 14.4 4.5 46.9 5.3 8.9 9.0 1.7 7.9 8.6 24.5 36.1 1.8 0.0 3.6 10.9 50.9 33.3 7.1 8.7 46.1 8.4 3.2 10.8 17.1 9.8 61.9 0.2 5.6 21.1 15.8 0.0 0.1 0.0 0.1 0.1 0.0 0.8 1.3 0.4 0.4 1.1 2.4 0.8 0.0 0.1 0.0 4.0 1.7 0.5 49.0 52.7 42.3 47.5 45.1 44.9 51.6 44.9 48.3 47.6 48.4 48.9 18.3 12.8 34.2 355.5 4.9 23.1 102.1 11.4 37.0 22.2 16.8 18.0 94.1 24.3 8.1 18.4 41.7 89.2 15.7 8.3 7.9 11.6 102.3 14.2 15.4 21.9 18.0 9.1 12.1 7.9 6.8 21.8 7.7 13.1 1.3 38.5 23.6 70.0 13.3 0.0 29.0 12.8 4.1 6.9 6.5 228.7 32.3 3.3 23.2 60.9 1.2 6.5 0.0 322.7 191.4 9.6 7.5 20.7 10.7 50.5 17.6 13.6 7.0 20.2 26.3 129.9 24.0 28.4 25.6 36.2 25.7 66.2 4.7 6.9 26.0 63.6 KARS1 "DFNB89, KARS, KARS2" ENSG00000065427 "Lysyl-tRNA synthetase 1" Q15046 16 75627474-75648643 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Host-virus interaction, Protein biosynthesis" "Aminoacyl-tRNA synthetase, Ligase, Transferase" "Charcot-Marie-Tooth disease, Deafness, Disease variant, Neurodegeneration, Neuropathy, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in some" 7 "Cardiomyocytes: 90.7;Cytotrophoblasts: 122.7;Extravillous trophoblasts: 143.3;Hofbauer cells: 89.5;Syncytiotrophoblasts: 110.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041345, HPA041550" Enhanced Supported "Plasma membrane,Cytosol" "Intracellular and membrane" NA NA 82000 "Cluster 27: Non-specific - Gene expression" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 24: Non-specific - Transcription regulation" Cytosol "Plasma membrane" "HPA041345: AB_10795589, HPA041550: AB_10794520" "unprognostic (1.56e-1)" "unprognostic (7.93e-2)" "unprognostic (3.36e-2)" "unprognostic (1.02e-2)" "unprognostic (5.39e-2)" "prognostic unfavorable (8.84e-6)" "unprognostic (6.24e-3)" "unprognostic (8.97e-3)" "unprognostic (1.18e-1)" "unprognostic (9.11e-3)" "unprognostic (8.71e-3)" "unprognostic (8.46e-2)" "unprognostic (7.86e-2)" "unprognostic (1.56e-1)" "unprognostic (1.03e-1)" "unprognostic (3.07e-2)" "unprognostic (2.13e-1)" 68.5 49.6 45.5 71.6 47.3 86.1 83.0 46.9 63.2 60.3 50.6 75.8 62.4 53.9 75.1 72.5 69.5 50.4 96.0 45.6 48.3 72.2 76.8 53.1 88.3 46.9 47.5 74.9 86.5 76.7 51.5 62.2 46.8 55.2 85.6 69.6 79.6 60.6 213.4 67.3 62.6 69.6 46.8 57.6 66.2 98.9 47.4 96.6 65.3 186.8 107.8 92.1 55.0 48.1 164.2 187.0 133.5 185.4 140.1 140.3 262.4 135.0 164.9 290.2 217.0 332.8 209.0 292.4 145.4 180.8 138.4 229.4 272.0 246.7 314.4 86.0 139.8 161.4 153.1 348.5 255.8 245.5 174.1 166.4 173.8 257.4 414.6 147.7 240.0 253.5 273.4 68.5 222.5 378.0 254.1 262.2 284.3 238.4 135.9 329.2 120.0 358.4 235.4 136.3 200.2 162.9 339.5 122.8 152.2 144.8 166.1 229.2 133.8 159.8 164.9 123.6 196.7 145.1 178.6 696.6 139.5 206.5 199.7 88.6 112.7 130.0 110.7 155.7 202.6 109.5 137.1 132.0 135.7 91.6 126.6 117.1 24.9 127.6 163.1 85.7 155.5 160.5 45.5 47.3 46.9 63.2 45.6 48.3 46.9 47.5 46.8 46.8 47.4 48.1 14.2 0.0 0.0 0.0 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 90.7 0.0 0.0 0.0 0.0 122.7 10.1 0.0 0.0 0.0 0.0 0.0 0.0 8.4 0.0 0.0 0.0 0.0 143.3 14.4 0.0 0.0 0.0 0.0 0.0 0.0 89.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 110.0 2.1 0.0 0.0 0.0 KCNA1 "AEMK, HUK1, Kv1.1, MBK1, RBK1" ENSG00000111262 "Potassium voltage-gated channel subfamily A member 1" Q09470 12 4909905-4918256 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Transport" "Ion channel, Potassium channel, Voltage-gated channel" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 13 "brain: 50.1" "Group enriched" "Detected in some" 6 "Bipolar cells: 15.1;Excitatory neurons: 39.6;Inhibitory neurons: 18.6;Oligodendrocyte precursor cells: 16.1" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "SCLC-21H: 1.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA074471 Approved NA NA "Cluster 65: Brain - Ion transport" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA074471: " "unprognostic (6.39e-3)" "unprognostic (2.64e-1)" "unprognostic (1.09e-1)" "unprognostic (8.44e-2)" "unprognostic (1.33e-1)" "unprognostic (1.79e-2)" "unprognostic (4.69e-3)" "unprognostic (2.48e-1)" "unprognostic (8.77e-5)" "unprognostic (6.30e-2)" "unprognostic (1.08e-4)" 0.2 0.0 10.6 0.0 22.5 0.0 0.3 27.6 50.1 0.6 3.9 1.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 21.0 7.9 0.0 0.0 0.0 0.0 24.9 10.7 0.0 0.0 0.8 0.9 0.0 25.2 0.0 0.0 1.3 0.5 0.0 0.0 0.0 0.2 0.1 9.5 0.0 1.2 0.0 24.3 1.2 0.6 0.0 0.0 0.3 0.3 28.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.6 22.5 27.6 50.1 21.0 7.9 24.9 10.7 25.2 9.5 24.3 28.2 0.1 0.0 0.0 2.0 0.0 0.4 0.0 0.0 0.0 15.1 0.0 0.1 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 39.6 0.0 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 18.6 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 2.8 0.0 0.2 0.0 16.1 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 3.6 0.5 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 KCNA2 "HK4, Kv1.2" ENSG00000177301 "Potassium voltage-gated channel subfamily A member 2" P16389 1 110519837-110631474 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Transport" "Ion channel, Potassium channel, Voltage-gated channel" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 8 "brain: 81.3" "Group enriched" "Detected in some" 4 "Astrocytes: 49.9;Excitatory neurons: 36.7;Inhibitory neurons: 37.1;Muller glia cells: 19.8;Oligodendrocyte precursor cells: 36.2" "Cancer enhanced" "Detected in some" "glioma: 1.2;testis cancer: 1.0" "Region enhanced" "Detected in many" "cerebral cortex: 81.3" "Immune cell enhanced" "Detected in single" "T-reg: 1.3" "Lineage enriched" "Detected in single" 8 "T-cells: 1.3" "Cell line enhanced" "Detected in some" "Karpas-707: 4.8;SCLC-21H: 1.4;U-2 OS: 1.2;U-266/70: 1.9;U-266/84: 3.1;WM-115: 1.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB001976 Enhanced NA NA "Cluster 35: T-regs - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 2: Karpas-707 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB001976: " "unprognostic (1.84e-2)" "unprognostic (9.70e-3)" "unprognostic (1.97e-1)" "unprognostic (2.98e-1)" "unprognostic (7.17e-3)" "unprognostic (6.68e-3)" "unprognostic (5.05e-3)" "unprognostic (2.02e-1)" "unprognostic (1.29e-1)" "unprognostic (4.50e-3)" "unprognostic (3.08e-3)" "unprognostic (2.93e-4)" "unprognostic (2.15e-1)" "unprognostic (3.55e-1)" "unprognostic (6.41e-2)" "unprognostic (2.83e-1)" 1.3 0.3 5.0 0.7 7.4 0.0 0.6 11.1 81.3 0.2 0.0 1.6 0.4 0.1 0.3 0.4 0.1 0.3 0.7 4.5 12.5 0.1 0.0 0.1 0.6 28.0 7.5 0.1 0.8 0.0 2.1 0.0 32.0 0.5 0.5 9.6 0.5 0.8 1.0 0.5 0.6 0.4 0.1 0.3 0.7 0.9 27.1 3.0 2.3 2.1 1.5 0.3 0.3 20.7 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 4.8 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.3 0.0 0.7 0.0 0.0 1.4 0.0 0.0 0.0 0.7 0.2 0.0 0.0 0.0 0.0 1.2 0.0 0.0 1.9 3.1 0.1 0.0 0.0 1.4 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.5 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 1.3 0.0 5.0 7.4 11.1 81.3 4.5 12.5 28.0 7.5 32.0 0.1 27.1 20.7 0.1 0.0 0.0 49.9 0.2 0.0 0.0 0.0 0.0 7.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.7 0.0 0.5 0.2 0.0 0.0 36.7 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 37.1 0.0 0.0 0.0 0.0 1.1 0.0 0.9 0.0 8.4 0.0 19.8 0.0 36.2 6.8 0.0 0.0 5.3 1.6 0.0 0.0 0.0 0.0 4.2 0.0 0.4 1.0 0.0 2.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 KCNB1 Kv2.1 ENSG00000158445 "Potassium voltage-gated channel subfamily B member 1" Q14721 20 49293394-49484297 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Exocytosis, Ion transport, Potassium transport, Transport" "Ion channel, Potassium channel, Voltage-gated channel" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "retina: 113.3" "Cell type enhanced" "Detected in many" "Bipolar cells: 115.6;Cone photoreceptor cells: 212.7;Excitatory neurons: 150.6;Inhibitory neurons: 89.9;Rod photoreceptor cells: 386.9" "Cancer enhanced" "Detected in some" "glioma: 1.3" "Region enhanced" "Detected in many" "cerebral cortex: 17.8" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC diff: 1.4;CACO-2: 2.2;HL-60: 1.1;hTCEpi: 1.2;U-2 OS: 1.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001979, HPA042434" Enhanced NA NA "Cluster 77: Retina - Visual perception" "Cluster 39: CACO-2 - Unknown function" "Cluster 46: Photoreceptor cells - Phototransduction" "CAB001979: , HPA042434: AB_2677996" "unprognostic (4.51e-1)" "unprognostic (1.72e-1)" "unprognostic (6.54e-3)" "unprognostic (4.87e-2)" "unprognostic (1.94e-1)" "unprognostic (1.82e-1)" "unprognostic (8.09e-2)" "unprognostic (6.22e-2)" "unprognostic (5.31e-1)" "unprognostic (8.32e-2)" "unprognostic (1.87e-3)" "unprognostic (1.37e-1)" "unprognostic (1.31e-2)" "unprognostic (2.07e-3)" "unprognostic (8.17e-2)" "unprognostic (9.35e-2)" "unprognostic (5.25e-4)" 10.7 1.5 4.3 0.3 6.6 0.0 2.8 0.0 17.8 1.2 0.0 6.2 0.2 7.3 0.8 1.7 6.0 0.6 1.2 6.6 0.0 0.3 2.4 0.3 0.0 0.0 0.0 0.4 0.3 0.2 2.7 0.1 0.0 2.2 0.6 113.3 1.6 3.1 7.3 0.5 2.0 5.0 0.0 0.3 3.4 0.4 0.0 0.1 0.1 4.4 0.0 3.8 0.9 7.9 0.0 0.0 0.3 0.0 1.4 0.1 0.0 0.0 0.1 0.1 0.0 2.2 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 1.1 0.0 0.2 1.2 0.0 0.0 0.1 0.0 0.0 0.0 0.7 0.5 0.1 0.0 0.9 0.0 0.0 0.4 0.0 0.4 0.0 0.0 0.0 0.9 0.7 0.6 0.9 0.0 0.0 0.7 0.0 0.0 0.9 1.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.3 6.6 0.0 17.8 6.6 0.0 0.0 0.0 0.0 0.0 0.0 7.9 20.2 0.0 2.2 7.8 0.5 0.8 0.2 0.0 0.0 115.6 0.9 0.5 3.4 1.5 0.7 0.0 212.7 0.0 0.4 0.0 0.0 0.0 0.7 19.8 2.9 8.0 0.0 0.0 150.6 0.0 0.0 1.4 0.0 4.2 3.8 1.5 0.0 5.7 0.1 18.5 89.9 0.0 0.0 0.0 0.3 0.8 4.4 0.4 0.0 12.2 0.0 38.2 0.0 43.2 3.3 0.1 0.0 34.6 0.1 0.1 0.0 0.2 4.0 386.9 0.0 0.9 7.0 0.2 0.5 0.2 0.3 0.1 0.4 0.2 0.0 0.1 KCNC1 Kv3.1 ENSG00000129159 "Potassium voltage-gated channel subfamily C member 1" P48547 11 17734774-17856804 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Transport" "Ion channel, Potassium channel, Voltage-gated channel" "Disease variant, Epilepsy, FDA approved drug targets, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "brain: 47.3" "Group enriched" "Detected in some" 5 "Bipolar cells: 79.6;Excitatory neurons: 48.2;Inhibitory neurons: 120.2" "Group enriched" "Detected in some" 5 "glioma: 1.1;testis cancer: 0.7" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 5 "basophil: 3.2;neutrophil: 1.4" "Lineage enriched" "Detected in single" 6 "granulocytes: 3.2" "Cell line enhanced" "Detected in some" "HeLa: 1.6;RH-30: 3.7;SCLC-21H: 3.5;SH-SY5Y: 2.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA047634, HPA048249" Enhanced Approved "Nucleoplasm,Nuclear membrane,Vesicles,Cytosol" NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 6: Brain - Smell perception" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Nuclear membrane" "Vesicles, Cytosol" "HPA047634: AB_2680109, HPA048249: " "unprognostic (1.79e-2)" "unprognostic (2.68e-1)" "unprognostic (1.33e-1)" "unprognostic (4.09e-3)" "unprognostic (1.12e-1)" "unprognostic (8.02e-2)" "unprognostic (2.40e-1)" "unprognostic (1.27e-1)" "unprognostic (8.37e-2)" "unprognostic (2.14e-1)" "unprognostic (7.04e-5)" "unprognostic (5.89e-2)" "unprognostic (7.32e-4)" "unprognostic (1.29e-1)" "unprognostic (5.44e-2)" "unprognostic (1.05e-2)" "unprognostic (7.83e-2)" 0.1 0.8 1.1 0.1 3.3 0.9 0.2 41.0 47.3 0.9 0.0 0.3 0.3 0.3 0.0 0.2 0.1 0.2 0.1 4.5 8.0 0.1 0.2 0.1 0.2 8.8 3.0 0.2 0.4 0.0 2.2 0.0 9.3 0.2 0.0 7.0 0.3 0.0 0.5 0.5 0.3 0.0 1.0 0.2 0.3 1.4 12.3 0.1 0.3 1.2 0.0 0.3 0.5 18.8 0.1 0.0 1.5 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.4 0.4 0.9 0.0 0.1 0.2 1.1 0.3 1.6 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.7 0.0 0.2 0.2 0.4 0.7 0.0 0.0 0.4 3.7 0.4 0.0 0.2 3.5 2.1 0.0 0.1 0.0 0.0 0.3 0.1 0.0 0.1 1.0 0.1 0.0 0.2 0.3 0.4 0.2 0.2 0.4 3.2 0.3 0.4 0.3 0.2 0.2 0.2 0.3 0.2 0.0 0.5 0.2 0.2 1.4 0.2 0.3 0.3 0.1 0.1 1.1 3.3 41.0 47.3 4.5 8.0 8.8 3.0 9.3 1.0 12.3 18.8 0.2 0.0 0.0 5.5 1.1 0.0 0.2 0.0 0.0 79.6 0.3 0.4 2.1 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.5 9.5 0.2 0.5 0.4 7.7 0.0 48.2 0.2 0.0 0.3 0.0 0.3 0.0 2.8 0.0 0.0 0.0 1.7 120.2 0.0 0.0 0.0 0.0 10.2 0.3 0.2 0.0 7.5 0.6 1.5 0.0 16.1 5.6 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 7.7 0.0 0.2 0.5 6.1 5.0 0.0 0.0 0.0 0.6 1.8 0.0 0.0 KCNC3 "Kv3.3, SCA13" ENSG00000131398 "Potassium voltage-gated channel subfamily C member 3" Q14003 19 50311937-50333515 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Transport" "Ion channel, Potassium channel, Voltage-gated channel" "Disease variant, FDA approved drug targets, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 75.8;thyroid gland: 52.1" "Cell type enhanced" "Detected in many" "Collecting duct cells: 20.2;Endometrial ciliated cells: 23.9;Excitatory neurons: 15.6;Glandular and luminal cells: 16.3;Inhibitory neurons: 18.3" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in many" "cerebral cortex: 75.8" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CACO-2: 7.7;CAPAN-2: 7.2;HDLM-2: 7.0;HMC-1: 20.3;K-562: 7.0;SK-BR-3: 14.0;T-47d: 12.0;U-2 OS: 8.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA018041 Approved NA NA "Cluster 7: Kidney - Transmembrane transport" "Cluster 3: HMC-1 - Innate immune response" "Cluster 44: Endometrium - Transcription" "HPA018041: AB_1855579" "unprognostic (8.05e-2)" "unprognostic (2.34e-2)" "unprognostic (3.01e-4)" "unprognostic (4.41e-2)" "unprognostic (3.84e-2)" "unprognostic (1.91e-2)" "unprognostic (2.79e-2)" "unprognostic (1.12e-2)" "unprognostic (1.46e-1)" "unprognostic (1.59e-1)" "unprognostic (3.94e-3)" "unprognostic (2.10e-5)" "prognostic unfavorable (1.23e-4)" "unprognostic (1.68e-2)" "unprognostic (1.45e-1)" "unprognostic (2.85e-2)" "unprognostic (1.19e-1)" 0.8 1.3 3.1 2.8 1.9 0.7 3.5 17.3 75.8 6.2 0.0 0.8 0.6 2.8 2.6 1.6 23.2 0.5 2.4 12.5 0.0 17.8 4.4 4.6 2.6 20.0 3.4 0.4 5.7 14.1 21.1 1.2 11.4 4.4 0.5 8.0 3.0 8.1 1.3 2.9 3.3 0.7 3.1 5.7 1.2 3.6 15.0 2.5 52.1 0.1 1.9 2.0 1.5 20.2 0.0 0.5 0.0 1.2 0.0 0.0 3.8 0.1 0.0 0.0 0.0 7.7 7.2 0.7 0.9 0.0 0.5 1.1 0.2 0.0 0.0 7.0 1.7 0.0 0.0 2.0 0.0 0.0 20.3 0.1 0.0 0.0 0.0 0.0 0.1 0.3 7.0 0.0 0.0 2.7 0.1 0.0 0.9 1.1 3.3 0.0 0.1 0.0 0.5 0.3 0.0 1.2 1.7 14.0 0.0 0.1 12.0 2.4 0.2 0.0 8.2 0.0 0.0 0.0 0.1 0.5 0.3 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 3.1 1.9 17.3 75.8 12.5 0.0 20.0 3.4 11.4 3.1 15.0 20.2 0.3 0.0 0.5 3.3 2.4 0.8 1.0 0.2 0.0 8.8 4.4 2.5 2.7 1.5 2.4 20.2 8.4 2.3 0.2 0.2 0.0 1.6 0.3 23.9 1.2 0.7 4.2 0.0 15.6 1.4 0.9 0.2 0.5 16.3 0.0 0.1 1.1 2.4 2.8 1.7 18.3 0.1 4.1 7.3 1.9 0.6 0.6 6.3 0.0 3.7 3.2 0.8 0.0 2.0 1.9 0.3 0.1 0.0 0.3 1.3 0.0 3.3 1.1 6.2 0.0 0.1 1.1 1.3 1.2 0.4 0.6 2.3 0.4 0.0 0.1 0.9 KCND3 "KSHIVB, Kv4.3, SCA19, SCA22" ENSG00000171385 "Potassium voltage-gated channel subfamily D member 3" Q9UK17 1 111770662-111989668 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Transport" "Ion channel, Potassium channel, Voltage-gated channel" "Brugada syndrome, Disease variant, FDA approved drug targets, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 35.6" "Cell type enhanced" "Detected in many" "Bipolar cells: 46.8;Cardiomyocytes: 38.1;Excitatory neurons: 105.7;Hepatocytes: 37.8;Inhibitory neurons: 88.4;Oligodendrocyte precursor cells: 45.8" "Cancer enhanced" "Detected in many" "prostate cancer: 8.4" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "OE19: 4.8;SCLC-21H: 10.1;U-2 OS: 1.6;WM-115: 2.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029452 Approved NA NA "Cluster 15: Liver - Metabolism" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA029452: AB_10602239" "unprognostic (1.11e-2)" "unprognostic (1.73e-3)" "unprognostic (1.71e-1)" "unprognostic (2.60e-2)" "unprognostic (1.37e-1)" "unprognostic (2.42e-1)" "unprognostic (1.41e-1)" "unprognostic (9.48e-2)" "unprognostic (1.15e-1)" "unprognostic (9.17e-2)" "unprognostic (1.86e-2)" "unprognostic (1.40e-1)" "unprognostic (7.44e-2)" "unprognostic (3.64e-1)" "unprognostic (1.23e-1)" "unprognostic (2.51e-3)" "unprognostic (6.64e-3)" 4.5 1.5 17.0 4.7 13.8 0.2 3.0 18.1 17.9 2.3 0.0 5.9 0.9 5.3 12.6 4.1 5.1 5.5 8.4 16.2 6.4 1.3 15.4 1.7 0.5 1.0 35.6 0.5 4.5 3.9 3.4 0.5 3.4 11.3 2.4 12.7 1.6 12.0 2.6 7.1 2.2 9.8 0.9 3.2 3.3 2.0 9.2 0.3 1.1 1.7 0.5 5.9 3.2 10.8 0.0 0.0 0.2 0.0 0.4 0.1 0.0 0.2 0.0 0.0 0.0 0.4 0.0 0.0 1.0 0.4 0.0 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.6 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.1 0.2 4.8 0.0 0.0 0.0 0.0 0.0 0.2 10.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 17.0 13.8 18.1 17.9 16.2 6.4 1.0 35.6 3.4 0.9 9.2 10.8 1.1 0.0 9.3 18.3 0.3 7.5 11.9 2.9 0.0 46.8 7.8 1.5 38.1 0.0 1.5 0.0 4.2 0.1 0.4 1.5 0.0 0.8 35.7 0.5 14.5 1.6 0.0 2.7 105.7 23.8 0.2 3.7 0.0 0.7 0.0 0.0 1.8 37.8 0.2 30.3 88.4 0.4 4.1 0.8 1.9 32.3 18.0 0.5 3.6 1.0 0.0 6.2 0.0 45.8 8.7 4.8 1.2 1.9 0.0 21.9 0.1 0.3 0.1 4.8 0.0 0.8 1.7 1.5 1.0 2.0 6.7 0.0 0.5 0.1 2.4 13.4 KCNJ10 "Kir1.2, Kir4.1" ENSG00000177807 "Potassium inwardly rectifying channel subfamily J member 10" P78508 1 159998651-160070160 "Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Transport" "Ion channel, Voltage-gated channel" "Deafness, Disease variant, Epilepsy, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 100.7;kidney: 28.0;retina: 36.7" "Group enriched" "Detected in some" 5 "Astrocytes: 93.0;Muller glia cells: 75.7;Oligodendrocyte precursor cells: 35.7;Oligodendrocytes: 93.7" "Cancer enriched" "Detected in some" 6 "glioma: 27.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "Hep G2: 6.7;SK-MEL-30: 2.1;U-266/70: 2.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA078302 Enhanced NA NA "Cluster 35: T-regs - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 5: Muller glia cells - Visual perception" "HPA078302: AB_2732378" "unprognostic (2.64e-2)" "unprognostic (3.54e-3)" "unprognostic (6.19e-2)" "unprognostic (1.33e-1)" "unprognostic (2.84e-1)" "unprognostic (6.98e-4)" "unprognostic (1.96e-1)" "unprognostic (7.13e-2)" "unprognostic (3.43e-1)" "unprognostic (1.28e-3)" "unprognostic (5.80e-4)" "unprognostic (9.52e-2)" "unprognostic (2.09e-2)" "unprognostic (2.08e-2)" "unprognostic (1.41e-1)" "unprognostic (3.77e-1)" "unprognostic (6.70e-3)" 0.1 0.3 56.7 2.1 86.3 0.0 0.1 100.2 58.4 0.2 8.7 0.5 0.2 0.1 0.0 0.1 0.1 0.1 0.1 51.4 78.7 28.0 2.1 0.1 7.3 92.7 94.7 0.1 0.1 0.1 0.4 0.0 87.5 0.2 0.2 36.7 0.3 0.2 0.1 0.4 0.5 0.0 71.8 10.5 0.9 0.6 83.6 0.4 0.2 0.1 1.9 0.1 0.1 100.7 0.0 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.2 0.0 0.1 1.0 0.1 0.0 0.6 0.2 0.1 0.0 0.1 0.0 0.1 0.0 0.0 6.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.1 0.3 0.0 1.2 0.1 0.0 0.0 0.1 0.2 0.0 0.1 2.1 0.5 0.0 0.3 0.1 0.0 0.2 0.5 0.0 2.0 1.0 0.0 0.1 0.1 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.4 0.0 0.0 0.6 0.0 56.7 86.3 100.2 58.4 51.4 78.7 92.7 94.7 87.5 71.8 83.6 100.7 0.1 0.0 0.0 93.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.3 0.5 0.0 0.0 3.7 4.2 0.0 0.0 0.0 11.7 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.4 0.0 0.0 13.0 0.0 1.1 0.0 1.1 0.0 3.7 0.0 75.7 0.0 35.7 93.7 0.0 0.0 0.0 0.3 0.0 0.0 0.3 0.0 3.5 0.0 0.1 0.1 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 KCNJ13 "Kir1.4, Kir7.1, LCA16" ENSG00000115474 "Potassium inwardly rectifying channel subfamily J member 13" O60928 2 232765802-232776565 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Transport" "Ion channel, Voltage-gated channel" "Cataract, Disease variant, Leber congenital amaurosis" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 8 "choroid plexus: 159.5;intestine: 91.3" "Group enriched" "Detected in some" 4 "Muller glia cells: 54.8;Proximal enterocytes: 217.4;Undifferentiated cells: 68.1" "Cancer enriched" "Detected in some" 5 "melanoma: 5.9" "Group enriched" "Detected in many" 4 "cerebellum: 7.3;hippocampal formation: 8.0;thalamus: 5.3;white matter: 3.4" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in single" "U-2197: 1.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA051609 Approved "Nuclear membrane" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 18: U-2197 - ECM organization" "Cluster 45: Enterocytes - Digestion" "Nuclear membrane" "HPA051609: " "unprognostic (4.29e-2)" "unprognostic (2.00e-1)" "unprognostic (2.69e-1)" "unprognostic (9.03e-5)" "unprognostic (1.17e-1)" "unprognostic (3.12e-2)" "unprognostic (2.26e-1)" "unprognostic (3.44e-2)" "unprognostic (1.40e-1)" "unprognostic (1.41e-1)" "unprognostic (4.90e-2)" "unprognostic (1.86e-2)" "unprognostic (2.04e-1)" "unprognostic (1.65e-1)" "unprognostic (1.82e-2)" "unprognostic (1.11e-2)" 0.1 0.1 0.4 0.0 1.3 0.4 0.1 7.3 1.1 0.1 159.5 0.1 7.9 0.1 0.3 0.1 0.0 2.2 0.1 8.0 0.4 3.3 0.2 0.1 0.2 1.3 0.8 0.2 0.8 15.8 0.2 0.0 1.3 0.1 0.0 13.7 0.2 1.1 0.1 3.2 91.3 0.1 0.4 0.1 2.3 0.5 5.3 0.1 7.0 0.0 0.0 0.1 0.2 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.8 0.0 0.0 0.0 0.0 0.0 1.2 0.1 0.3 0.0 0.2 0.2 0.1 0.0 1.9 0.3 0.3 0.3 0.0 0.4 0.2 0.6 0.2 0.1 0.3 0.7 0.3 0.3 0.4 0.4 0.3 1.0 0.0 0.4 1.3 7.3 1.1 8.0 0.4 1.3 0.8 1.3 0.4 5.3 3.4 0.1 0.0 0.0 1.0 0.0 0.5 0.0 0.0 0.0 0.5 0.0 0.5 0.5 0.0 0.0 1.8 0.0 0.0 0.2 0.1 1.9 0.0 3.0 0.7 0.3 0.2 0.0 0.0 1.1 1.3 0.8 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 1.2 25.7 0.0 0.0 0.0 0.6 0.0 0.1 21.4 0.0 0.0 54.8 0.0 1.5 2.0 0.0 8.8 0.0 0.0 0.1 217.4 0.2 0.0 1.7 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.1 0.1 0.0 68.1 0.0 KCNMA1 "KCa1.1, mSLO1, SLO" ENSG00000156113 "Potassium calcium-activated channel subfamily M alpha 1" Q12791 10 76869601-77638369 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Transport" "Ion channel, Potassium channel, Voltage-gated channel" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "endometrium 1: 138.7" "Cell type enhanced" "Detected in many" "Astrocytes: 471.1;Bipolar cells: 409.8;Excitatory neurons: 1023.7;Inhibitory neurons: 635.9;Oligodendrocyte precursor cells: 708.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "intermediate monocyte: 2.4;non-classical monocyte: 1.7" "Lineage enhanced" "Detected in single" "monocytes: 2.4" "Cell line enhanced" "Detected in many" "BJ: 100.8;hTERT-HME1: 115.3;PC-3: 159.6;U-138 MG: 112.6;U-87 MG: 109.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054648 Approved NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA054648: AB_2682556" "unprognostic (1.25e-1)" "unprognostic (2.23e-2)" "unprognostic (1.86e-2)" "unprognostic (5.29e-2)" "unprognostic (9.43e-2)" "unprognostic (2.25e-1)" "unprognostic (1.77e-1)" "unprognostic (2.81e-2)" "unprognostic (1.87e-1)" "unprognostic (1.34e-1)" "unprognostic (4.12e-3)" "unprognostic (1.20e-1)" "unprognostic (2.26e-2)" "unprognostic (1.42e-2)" "unprognostic (5.19e-2)" "unprognostic (1.42e-2)" "unprognostic (3.99e-3)" 10.9 12.6 36.2 8.9 38.0 1.0 15.8 1.0 45.0 54.4 4.2 118.2 7.3 138.7 31.4 33.7 47.8 22.4 3.7 36.4 10.1 11.4 19.2 9.6 7.8 4.8 15.2 13.9 8.0 0.2 26.9 4.8 5.7 48.3 21.1 40.2 42.8 76.1 96.6 5.0 23.3 92.8 1.0 24.1 33.6 5.8 15.6 2.1 3.0 18.7 3.5 44.3 24.6 28.4 0.3 30.3 0.1 0.3 4.6 24.8 0.3 100.8 89.2 23.9 11.8 6.7 0.6 0.0 0.7 75.9 56.8 0.2 0.0 59.0 14.6 60.9 0.6 0.0 0.0 0.0 45.0 0.0 0.4 17.4 10.7 38.3 115.3 84.0 9.8 0.5 0.0 0.0 42.6 1.2 1.9 0.2 1.8 0.2 159.6 0.1 3.6 0.1 15.3 0.2 9.1 1.1 0.0 2.5 0.1 11.9 12.2 0.1 65.4 112.6 12.7 20.6 90.0 0.0 0.2 0.0 109.8 0.1 45.1 0.0 0.1 0.0 0.0 2.4 0.0 0.7 0.0 0.0 0.3 0.1 0.0 0.0 0.1 0.0 1.7 0.0 0.0 0.1 36.2 38.0 1.0 45.0 36.4 10.1 4.8 15.2 5.7 1.0 15.6 28.4 0.9 0.0 4.3 471.1 2.8 2.0 71.7 5.7 17.6 409.8 30.4 43.9 3.5 5.7 4.8 1.8 60.5 0.3 0.5 2.8 29.4 3.3 74.4 20.9 17.9 3.4 4.9 0.0 1023.7 10.7 0.2 16.2 0.5 29.7 0.0 1.9 2.5 27.3 10.8 6.7 635.9 59.6 46.8 106.0 3.9 63.1 3.7 36.7 48.0 133.0 4.0 52.3 0.0 708.2 33.9 8.7 1.4 1.2 8.7 64.0 1.4 0.9 0.1 17.2 6.6 20.6 19.2 3.4 2.5 7.7 0.3 0.3 0.7 177.2 1.7 2.4 KCNQ2 "BFNC, EBN, EBN1, ENB1, HNSPC, KCNA11, Kv7.2" ENSG00000075043 "Potassium voltage-gated channel subfamily Q member 2" O43526 20 63400208-63472677 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Transport" "Ion channel, Potassium channel, Voltage-gated channel" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "brain: 91.9" "Cell type enhanced" "Detected in some" "Early spermatids: 16.5;Excitatory neurons: 61.7;Horizontal cells: 13.5;Inhibitory neurons: 37.5;Oligodendrocyte precursor cells: 50.8;Spermatogonia: 28.3" "Cancer enriched" "Detected in some" 9 "glioma: 8.7" "Group enriched" "Detected in many" 4 "amygdala: 55.7;basal ganglia: 37.2;cerebellum: 27.8;cerebral cortex: 91.9;hippocampal formation: 68.1" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 21.2;AN3-CA: 35.0;NTERA-2: 19.3;SCLC-21H: 67.8;SH-SY5Y: 119.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016642, HPA057112" Enhanced Approved "Endoplasmic reticulum" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Endoplasmic reticulum" "HPA016642: AB_1855555, HPA057112: AB_2683339" "unprognostic (2.35e-1)" "unprognostic (1.41e-1)" "unprognostic (2.22e-4)" "unprognostic (8.21e-6)" "unprognostic (6.18e-2)" "unprognostic (7.58e-2)" "unprognostic (6.06e-2)" "unprognostic (3.16e-1)" "unprognostic (1.73e-1)" "unprognostic (1.92e-1)" "unprognostic (9.96e-2)" "unprognostic (9.39e-2)" "unprognostic (1.43e-5)" "unprognostic (4.36e-2)" "unprognostic (1.02e-1)" "unprognostic (1.81e-1)" "unprognostic (2.70e-2)" 0.0 6.2 55.7 0.1 37.2 0.0 0.0 27.8 91.9 0.0 0.0 0.6 0.1 0.0 0.1 0.0 0.3 0.3 0.2 68.1 0.0 0.1 0.0 0.0 0.0 2.6 0.0 0.0 1.1 0.0 19.1 0.0 0.1 1.6 0.0 2.2 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.1 0.2 10.6 1.0 0.0 0.0 0.0 0.0 0.0 0.1 12.9 0.0 0.0 21.2 35.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.2 0.0 0.6 0.0 8.3 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 19.3 0.5 0.2 0.0 0.0 0.1 0.0 0.0 67.8 119.3 0.1 0.0 0.0 0.8 0.2 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.0 55.7 37.2 27.8 91.9 68.1 0.0 2.6 0.0 0.1 0.0 1.0 12.9 0.6 0.0 0.0 7.2 0.1 0.1 0.0 0.0 0.0 5.7 0.0 0.3 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 16.5 0.0 0.1 1.0 0.0 0.0 61.7 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.0 0.0 13.5 37.5 0.2 0.0 0.0 0.0 8.1 0.6 0.1 0.0 1.0 0.0 0.9 0.0 50.8 2.1 0.0 0.0 0.4 0.0 0.3 0.0 0.1 0.0 2.5 0.0 0.1 0.1 7.4 28.3 0.0 0.0 0.0 0.3 0.0 0.1 0.0 KCNQ3 "EBN2, Kv7.3" ENSG00000184156 "Potassium voltage-gated channel subfamily Q member 3" O43525 8 132120859-132481095 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Transport" "Ion channel, Potassium channel, Voltage-gated channel" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 9 "brain: 23.7" "Group enriched" "Detected in some" 4 "Excitatory neurons: 501.5;Inhibitory neurons: 485.6;Microglial cells: 502.2" "Cancer enhanced" "Detected in many" "thyroid cancer: 2.6" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "hTERT-HME1: 6.6;JURKAT: 3.8;RPMI-8226: 2.8;U-2 OS: 4.3;U-87 MG: 3.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 30: Epithelial cell lines - Translation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (2.90e-1)" "unprognostic (1.26e-3)" "unprognostic (1.45e-2)" "unprognostic (3.65e-5)" "unprognostic (2.32e-1)" "unprognostic (4.60e-2)" "unprognostic (5.57e-6)" "unprognostic (5.82e-2)" "unprognostic (7.32e-2)" "unprognostic (6.09e-2)" "unprognostic (7.09e-2)" "unprognostic (3.22e-1)" "unprognostic (2.71e-4)" "unprognostic (1.14e-3)" "unprognostic (3.52e-1)" "unprognostic (7.92e-2)" "unprognostic (2.50e-2)" 1.3 1.4 9.9 0.5 21.2 0.0 0.9 0.0 23.7 0.3 0.0 0.4 0.2 0.2 0.1 0.1 0.3 0.3 0.7 9.1 4.7 0.7 0.0 1.9 0.1 4.7 8.1 0.1 0.9 0.2 1.9 0.2 7.4 0.4 0.2 2.5 0.3 0.6 0.0 0.4 0.6 0.5 0.0 0.5 0.1 0.2 16.0 0.5 0.5 0.0 0.2 0.4 0.4 8.7 0.2 0.1 0.0 0.0 0.3 1.0 0.0 0.3 1.1 0.0 0.0 0.0 1.0 0.0 1.2 1.5 2.5 0.0 0.0 2.5 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 1.7 6.6 0.1 0.0 3.8 0.0 0.1 0.9 0.0 0.0 0.0 0.5 0.0 0.2 0.0 0.0 2.8 1.6 0.0 1.3 1.2 0.4 0.0 0.0 0.2 0.0 1.0 0.0 0.0 4.3 0.1 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.9 21.2 0.0 23.7 9.1 4.7 4.7 8.1 7.4 0.0 16.0 8.7 0.4 0.0 14.0 84.5 0.2 0.3 0.0 0.0 0.0 6.7 1.3 0.6 4.6 0.0 1.3 0.0 0.0 0.0 0.0 0.1 0.0 4.3 1.6 0.3 4.2 2.7 0.0 0.0 501.5 6.0 0.0 0.8 0.0 0.1 0.0 0.1 0.0 0.0 0.2 0.0 485.6 0.7 0.0 0.3 1.6 2.9 0.0 2.1 0.0 502.2 0.6 0.4 0.0 117.1 31.2 1.8 0.0 0.0 0.0 0.1 4.6 1.6 0.8 0.6 0.0 0.0 2.7 0.0 0.5 0.1 0.1 0.0 0.4 0.1 1.2 0.1 KCNQ4 "DFNA2, Kv7.4" ENSG00000117013 "Potassium voltage-gated channel subfamily Q member 4" P56696 1 40783787-40840452 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Hearing, Ion transport, Potassium transport, Transport" "Ion channel, Potassium channel, Voltage-gated channel" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 5.1;intestine: 5.4" "Cell type enhanced" "Detected in some" "Excitatory neurons: 5.1;Inhibitory neurons: 9.7;Muller glia cells: 4.2;Sertoli cells: 6.6" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in some" "midbrain: 5.1" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HAP1: 1.8;HEK 293: 2.2;K-562: 2.6;MCF7: 1.4;REH: 1.3;THP-1: 1.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA018305 Uncertain NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 1: K-562 - Erythropoiesis" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA018305: AB_1855556" "unprognostic (1.42e-2)" "unprognostic (1.56e-1)" "unprognostic (8.43e-3)" "unprognostic (4.59e-3)" "unprognostic (8.51e-2)" "unprognostic (1.64e-1)" "unprognostic (1.29e-2)" "unprognostic (5.86e-2)" "unprognostic (4.34e-2)" "unprognostic (6.64e-2)" "unprognostic (1.20e-1)" "unprognostic (7.40e-2)" "unprognostic (5.18e-4)" "unprognostic (2.68e-1)" "unprognostic (1.22e-1)" "unprognostic (3.17e-2)" "unprognostic (3.44e-2)" 0.9 0.1 0.1 0.3 0.6 0.0 0.6 0.2 1.7 0.9 2.4 5.4 0.4 2.8 0.1 1.0 2.3 0.3 0.6 0.2 0.2 0.1 0.1 0.5 0.0 0.7 5.1 0.5 0.4 0.2 0.3 0.5 0.7 1.1 0.3 0.4 1.4 1.1 3.2 0.6 1.2 1.5 0.8 0.0 1.3 0.2 0.1 0.3 0.2 1.0 0.0 2.3 0.7 2.0 0.0 0.1 0.1 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.1 0.6 0.1 0.2 0.0 0.0 0.0 1.8 0.0 0.0 0.0 2.2 0.9 0.1 0.0 0.1 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.3 2.6 0.0 0.0 1.4 0.3 0.0 0.2 0.0 0.0 1.3 0.0 0.0 0.2 0.0 1.1 0.2 0.0 0.6 0.2 0.1 0.1 1.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.2 1.7 0.2 0.2 0.7 5.1 0.7 0.8 0.1 2.0 0.3 0.0 0.0 0.7 0.0 0.1 0.1 0.0 0.0 0.4 1.8 1.5 2.1 0.0 0.0 0.0 2.1 0.1 0.0 0.5 0.0 1.2 0.2 0.2 0.1 0.3 1.8 0.8 5.1 0.2 0.0 0.2 0.0 0.4 0.0 0.3 0.0 0.0 2.2 0.0 9.7 1.2 0.0 0.0 0.4 0.2 0.0 0.1 0.0 0.0 0.0 4.2 0.0 2.5 1.5 0.6 0.5 0.7 0.3 0.2 0.0 0.0 0.0 0.3 6.6 2.0 2.8 0.2 0.7 1.0 0.4 0.0 0.0 0.1 1.1 0.1 KCNT1 "KCa4.1, KIAA1422, SLACK, Slo2.2" ENSG00000107147 "Potassium sodium-activated channel subfamily T member 1" Q5JUK3 9 135702185-135795508 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Transport" "Ion channel, Potassium channel" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 37.1;lymphoid tissue: 15.8;skeletal muscle: 13.4" "Group enriched" "Detected in some" 8 "Excitatory neurons: 60.1;Inhibitory neurons: 55.0;Theca cells: 21.2" "Cancer enhanced" "Detected in single" "ovarian cancer: 0.8" "Region enhanced" "Detected in many" "cerebral cortex: 37.1" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "OE19: 2.5;RPMI-8226: 1.8;SCLC-21H: 3.7" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebellum: 42.8" HPA059880 Uncertain NA NA "Cluster 47: Non-specific - Unknown function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA059880: AB_2684149" "unprognostic (1.50e-3)" "unprognostic (1.72e-2)" "unprognostic (2.07e-3)" "unprognostic (2.98e-13)" "unprognostic (9.26e-2)" "unprognostic (7.73e-2)" "unprognostic (9.60e-2)" "unprognostic (1.67e-1)" "unprognostic (1.15e-1)" "unprognostic (1.30e-3)" "unprognostic (9.89e-2)" "unprognostic (6.20e-2)" "unprognostic (4.89e-7)" "unprognostic (9.15e-2)" "unprognostic (2.70e-1)" "unprognostic (2.26e-1)" "unprognostic (1.66e-2)" 0.4 0.1 3.9 0.1 7.9 0.1 0.3 1.9 37.1 0.3 0.0 0.3 0.1 0.1 0.1 0.2 0.6 0.2 1.2 4.2 0.0 0.0 0.1 0.3 0.0 4.5 0.0 5.0 0.1 0.0 8.7 0.3 2.8 0.1 0.0 0.4 0.2 0.0 13.4 0.1 0.2 0.0 0.0 15.8 0.5 0.9 0.0 0.0 0.1 8.2 0.0 0.2 0.2 12.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 2.5 0.0 0.0 0.8 1.8 0.0 0.0 3.7 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.9 7.9 1.9 37.1 4.2 0.0 4.5 0.0 2.8 0.0 0.0 12.5 0.0 0.0 0.0 3.6 0.1 0.0 0.3 0.0 0.0 1.3 0.0 0.0 4.5 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.1 0.0 0.2 0.0 0.0 60.1 0.0 0.0 0.4 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 55.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 4.7 0.0 0.3 0.0 3.5 2.7 0.0 0.0 0.7 0.0 0.1 0.0 0.2 0.0 0.6 0.0 5.1 1.1 0.3 1.0 0.0 0.0 0.0 0.1 21.2 0.0 0.0 KCNT2 "KCa4.2, SLICK, SLO2.1" ENSG00000162687 "Potassium sodium-activated channel subfamily T member 2" Q6UVM3 1 196225779-196609225 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Transport" "Ion channel, Potassium channel" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "ovary: 3.8" "Group enriched" "Detected in some" 4 "Excitatory neurons: 220.2;Inhibitory neurons: 240.5;Oligodendrocyte precursor cells: 310.7" "Cancer enhanced" "Detected in some" "renal cancer: 1.4" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HHSteC: 3.2;hTERT-RPE1: 9.0;SCLC-21H: 7.5;SH-SY5Y: 5.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA051218 Uncertain Approved Vesicles NA NA "Cluster 15: Liver - Metabolism" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles "HPA051218: AB_2681392" "unprognostic (5.06e-2)" "unprognostic (2.94e-2)" "unprognostic (8.01e-2)" "unprognostic (5.10e-6)" "unprognostic (1.22e-3)" "unprognostic (1.30e-2)" "unprognostic (1.07e-1)" "unprognostic (3.03e-2)" "unprognostic (5.90e-2)" "unprognostic (2.18e-1)" "unprognostic (9.56e-3)" "unprognostic (2.61e-1)" "prognostic unfavorable (1.67e-5)" "unprognostic (3.30e-4)" "unprognostic (2.95e-2)" "unprognostic (4.75e-1)" "unprognostic (1.72e-3)" 1.0 0.6 0.9 0.1 2.0 0.0 0.4 0.0 2.0 0.4 0.3 0.5 0.2 0.3 0.4 1.0 0.5 1.4 1.8 2.5 3.3 0.3 2.8 1.8 0.1 0.0 0.2 3.8 0.1 0.0 0.9 0.2 0.0 1.0 0.5 0.1 0.5 0.6 0.1 0.3 0.4 0.5 0.6 0.2 0.5 1.1 1.0 0.1 1.1 0.8 0.1 0.8 0.4 0.5 0.0 0.1 1.8 0.0 0.2 0.2 0.0 0.0 1.0 0.1 1.8 0.0 0.0 0.0 0.2 0.0 0.7 0.0 0.0 0.0 0.4 0.0 0.2 0.0 0.9 0.0 3.2 0.0 0.0 1.2 0.0 0.4 0.1 9.0 0.2 0.0 0.0 0.0 0.2 0.0 0.2 0.0 2.4 0.0 0.1 0.0 0.1 0.0 0.0 0.5 7.5 5.6 0.0 0.0 0.1 1.9 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.2 0.0 0.0 0.9 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 2.0 0.0 2.0 2.5 3.3 0.0 0.2 0.0 0.6 1.0 0.5 0.8 41.7 1.1 6.8 0.0 0.4 0.2 0.0 0.6 0.0 0.0 0.1 1.4 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.2 0.0 0.2 0.8 0.0 0.0 220.2 0.0 0.0 9.3 0.0 0.0 0.0 6.1 2.5 6.2 0.0 0.0 240.5 0.0 0.0 0.0 0.7 3.3 6.5 0.0 1.8 58.1 0.0 0.0 0.0 310.7 6.1 0.0 0.0 4.9 0.0 0.1 0.0 0.4 0.0 0.0 0.0 1.4 4.0 0.6 0.2 0.0 0.0 0.0 0.0 3.9 0.0 0.2 KCNV2 Kv8.2 ENSG00000168263 "Potassium voltage-gated channel modifier subfamily V member 2" Q8TDN2 9 2717510-2730037 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Transport" "Ion channel, Potassium channel, Voltage-gated channel" "Cone-rod dystrophy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 59 "retina: 289.1" "Group enriched" "Detected in some" 6 "Cone photoreceptor cells: 515.0;Rod photoreceptor cells: 530.1" "Cancer enriched" "Detected in single" 78 "testis cancer: 6.2" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA031131 Enhanced NA NA "Cluster 79: Retina - Phototransduction" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA031131: AB_10609996" "unprognostic (5.06e-2)" "unprognostic (1.47e-3)" "unprognostic (3.45e-3)" "unprognostic (6.41e-2)" "unprognostic (1.31e-1)" "unprognostic (2.28e-2)" "unprognostic (1.12e-3)" "unprognostic (5.38e-2)" "unprognostic (1.39e-2)" "unprognostic (1.69e-1)" "unprognostic (5.21e-2)" "unprognostic (2.35e-1)" "unprognostic (7.96e-8)" "unprognostic (3.01e-1)" "unprognostic (4.90e-2)" "unprognostic (9.90e-2)" "unprognostic (1.06e-2)" 0.0 0.0 1.1 0.0 1.0 0.0 0.0 0.1 1.3 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.9 0.1 0.1 0.0 0.1 0.0 0.1 0.0 0.2 0.1 0.0 0.1 0.0 0.0 0.0 0.0 289.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 4.9 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.2 0.1 0.5 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 1.0 0.1 1.3 0.9 0.1 0.1 0.0 0.0 0.0 0.4 0.2 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 49.6 0.0 0.0 0.2 0.0 0.0 0.0 515.0 0.0 0.0 0.0 0.0 0.0 81.5 0.0 0.0 2.3 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 25.2 1.3 0.0 0.0 0.0 0.0 25.3 0.6 0.0 0.0 0.0 0.0 69.1 0.0 0.5 1.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 530.1 13.1 0.0 0.0 7.4 14.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 KCTD17 FLJ12242 ENSG00000100379 "Potassium channel tetramerization domain containing 17" Q8N5Z5 22 37051736-37063390 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cilium biogenesis/degradation, Ubl conjugation pathway" "Disease variant, Dystonia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 113.7" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Region enriched" "Detected in all" 4 "basal ganglia: 90.8" HPA018459 Uncertain NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 65: Brain - Ion transport" "Cluster 17: WM-115 - Nervous system development" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "HPA018459: AB_1852169" "unprognostic (1.09e-2)" "unprognostic (2.33e-1)" "unprognostic (1.09e-1)" "unprognostic (1.61e-2)" "unprognostic (5.38e-2)" "unprognostic (3.09e-3)" "prognostic unfavorable (3.59e-5)" "unprognostic (1.89e-1)" "unprognostic (4.90e-2)" "unprognostic (2.19e-1)" "prognostic favorable (4.22e-5)" "unprognostic (8.62e-2)" "prognostic unfavorable (5.13e-12)" "unprognostic (2.32e-1)" "unprognostic (1.57e-1)" "unprognostic (2.32e-1)" "unprognostic (6.94e-2)" 8.2 15.6 64.8 9.8 113.7 2.4 6.7 46.0 71.6 14.2 44.4 15.9 3.4 14.9 1.8 7.2 10.7 8.5 26.6 68.0 54.1 5.8 3.5 9.3 10.6 44.8 70.4 13.7 3.7 7.8 43.0 6.5 52.4 11.2 5.2 3.6 3.4 9.0 1.7 21.1 10.4 9.4 43.8 11.1 7.9 46.0 83.8 7.0 7.6 3.0 6.9 16.9 13.0 55.5 15.9 20.5 31.7 23.7 14.9 14.8 1.2 16.2 15.6 25.9 22.3 4.4 4.6 12.2 10.9 20.8 20.3 4.2 10.0 19.0 10.9 23.8 26.8 5.2 5.6 4.9 22.1 0.0 6.1 17.3 9.2 26.6 5.8 17.5 33.6 15.9 1.2 13.2 16.5 12.8 11.0 0.3 20.3 9.4 17.4 19.8 8.4 3.6 6.7 4.1 26.4 32.9 15.0 14.1 7.5 6.6 3.8 4.2 19.6 33.5 31.2 16.0 12.0 17.7 5.5 2.0 29.6 7.3 18.6 0.0 0.8 0.0 0.9 1.0 0.9 1.2 0.6 0.9 0.9 0.4 0.8 0.6 0.0 1.6 0.4 0.2 1.0 0.4 64.8 113.7 46.0 71.6 68.0 54.1 44.8 70.4 52.4 43.8 83.8 55.5 8.8 0.0 0.5 11.1 5.8 1.5 4.6 2.8 1.2 17.3 1.3 1.5 5.0 4.3 0.8 5.5 2.1 0.4 5.0 17.7 0.0 11.9 24.9 0.7 12.7 9.7 13.1 0.8 22.4 6.1 2.8 9.9 4.1 0.9 4.5 12.0 12.8 0.5 9.2 13.5 11.6 5.3 0.0 9.6 17.0 28.1 10.5 9.8 3.6 1.9 13.0 16.4 8.2 4.5 7.1 3.2 16.0 9.1 4.6 1.2 0.5 2.5 1.5 7.8 0.0 7.8 11.7 19.7 7.1 1.3 4.8 7.5 8.5 10.2 7.0 2.4 KCTD7 "CLN14, EPM3, FLJ32069" ENSG00000243335 "Potassium channel tetramerization domain containing 7" Q96MP8 7 66628881-66649067 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Disease variant, Epilepsy, Neurodegeneration, Neuronal ceroid lipofuscinosis" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "retina: 65.7" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 37.5;Oligodendrocytes: 42.7;Rod photoreceptor cells: 53.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 77: Retina - Visual perception" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 46: Photoreceptor cells - Phototransduction" "unprognostic (4.53e-1)" "unprognostic (2.30e-2)" "prognostic unfavorable (8.07e-4)" "unprognostic (1.30e-3)" "unprognostic (3.74e-2)" "unprognostic (1.34e-2)" "unprognostic (4.49e-5)" "unprognostic (1.26e-2)" "unprognostic (2.64e-1)" "unprognostic (2.97e-2)" "prognostic favorable (3.26e-4)" "unprognostic (1.45e-1)" "unprognostic (7.76e-2)" "unprognostic (1.76e-1)" "unprognostic (1.46e-1)" "unprognostic (3.58e-2)" "unprognostic (3.19e-2)" 9.4 11.6 18.3 8.7 21.8 5.6 7.8 22.2 20.4 16.0 12.7 17.0 5.1 14.0 13.7 4.8 13.0 7.1 10.1 17.8 19.3 8.7 5.9 7.9 12.4 24.7 21.6 20.8 5.2 10.0 13.8 7.8 24.6 10.9 6.9 65.7 6.6 10.1 5.9 6.3 12.6 8.6 19.7 10.9 10.8 17.5 23.1 8.0 10.0 6.6 12.1 16.6 10.4 32.1 4.5 6.3 17.5 12.8 8.2 10.5 1.2 6.6 7.0 10.2 9.6 9.0 5.3 14.4 1.7 8.3 25.0 2.4 14.4 2.3 10.4 13.0 6.4 1.6 16.0 7.8 4.4 3.9 11.6 6.6 7.3 8.4 5.0 14.4 5.3 6.9 13.8 12.5 8.5 1.6 3.8 5.7 11.1 1.6 6.8 4.7 7.2 5.8 6.9 1.6 8.8 16.2 5.5 3.5 15.4 16.8 5.6 4.5 6.8 13.1 9.5 4.5 5.8 5.4 4.0 11.2 17.2 5.2 10.2 2.5 1.2 6.9 3.3 0.9 3.6 2.1 2.8 2.7 1.2 3.4 1.8 2.7 0.9 2.6 1.3 1.1 3.1 1.4 18.3 21.8 22.2 20.4 17.8 19.3 24.7 21.6 24.6 19.7 23.1 32.1 5.4 3.2 9.0 20.2 10.5 1.1 1.7 2.8 8.0 17.1 3.8 3.0 12.0 0.0 2.9 0.0 37.5 5.2 9.3 1.8 1.9 1.2 9.0 4.6 10.2 4.8 8.4 3.4 14.9 1.2 2.2 6.3 4.1 3.3 5.1 12.5 6.8 2.0 5.9 18.5 16.5 2.7 0.0 3.8 1.6 18.2 6.5 6.6 1.8 27.2 4.2 20.3 12.3 7.5 42.7 1.2 5.2 12.4 7.1 1.5 4.0 1.7 3.0 53.1 6.6 5.8 7.2 13.0 9.9 1.7 1.1 2.7 10.7 5.4 2.2 0.6 KIAA1549 ENSG00000122778 KIAA1549 Q9HCM3 7 138831381-138981389 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 56.3;Excitatory neurons: 92.2;Inhibitory neurons: 54.6;Oligodendrocyte precursor cells: 69.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "PC-3: 20.6;SH-SY5Y: 21.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019560 Uncertain Approved "Nuclear membrane,Intermediate filaments" NA NA 14000 "Cluster 58: Brain - Synaptic function" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nuclear membrane" "Intermediate filaments" "HPA019560: AB_1852418" "unprognostic (7.88e-2)" "unprognostic (2.37e-2)" "unprognostic (2.63e-1)" "unprognostic (6.85e-2)" "unprognostic (2.29e-1)" "unprognostic (8.86e-2)" "unprognostic (2.55e-2)" "unprognostic (6.40e-2)" "unprognostic (1.02e-1)" "unprognostic (2.19e-2)" "unprognostic (2.33e-2)" "unprognostic (8.30e-2)" "prognostic favorable (3.93e-7)" "unprognostic (1.40e-1)" "unprognostic (2.17e-1)" "unprognostic (2.38e-1)" "unprognostic (1.28e-2)" 0.6 1.7 2.7 0.3 3.0 0.3 1.5 0.0 4.4 1.4 0.0 0.8 0.7 1.7 1.8 0.5 2.2 1.0 1.2 4.3 0.8 3.9 0.4 1.8 0.2 1.6 2.5 1.2 6.3 2.4 1.8 1.3 0.0 1.5 0.7 5.7 2.4 5.5 0.5 0.8 0.7 1.3 1.4 0.3 1.3 1.2 2.5 2.4 0.7 0.8 0.2 1.1 0.6 2.4 4.9 9.2 9.1 14.9 0.1 0.0 4.2 5.2 4.6 2.6 3.4 8.4 2.6 0.0 2.9 8.2 8.6 1.0 5.7 1.4 3.6 2.5 3.8 2.6 11.5 2.2 1.3 3.8 3.2 1.2 2.8 0.9 1.4 3.5 4.8 3.4 1.7 0.1 3.6 4.5 2.9 4.7 7.8 4.1 20.6 6.8 4.5 0.0 1.7 3.3 11.8 21.5 2.6 5.2 2.2 5.1 3.7 2.4 3.3 2.9 2.8 0.1 5.1 0.9 0.0 0.1 4.0 1.4 7.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.7 3.0 0.0 4.4 4.3 0.8 1.6 2.5 0.0 1.4 2.5 2.4 2.0 0.0 2.2 11.8 0.1 0.5 2.1 1.6 0.6 18.5 6.3 4.6 2.5 0.0 2.9 7.3 56.3 2.5 0.2 0.3 0.0 2.3 0.5 8.5 8.1 4.8 10.8 1.3 92.2 3.2 2.2 3.0 3.6 8.0 16.5 13.8 2.2 0.8 0.5 3.3 54.6 2.5 6.1 0.8 1.2 0.2 1.5 0.5 1.8 26.2 0.0 7.2 0.0 69.9 2.2 5.0 1.4 2.6 1.0 3.1 0.5 8.1 12.2 29.2 6.6 2.2 2.9 0.3 7.2 0.1 0.9 1.5 1.1 2.4 2.9 1.6 KIF1A "ATSV, C2orf20, SPG30, UNC104" ENSG00000130294 "Kinesin family member 1A" Q12756 2 240713761-240824293 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Motor protein" "Disease variant, Hereditary spastic paraplegia, Mental retardation, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 115.0;pancreas: 34.1;pituitary gland: 42.1;retina: 58.4" "Cell type enhanced" "Detected in many" "Bipolar cells: 393.8;Cone photoreceptor cells: 419.1;Horizontal cells: 536.7;Muller glia cells: 116.4;Rod photoreceptor cells: 176.8" "Cancer enhanced" "Detected in many" "glioma: 20.1" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AN3-CA: 62.5;HAP1: 146.0;SCLC-21H: 276.0;SH-SY5Y: 52.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005442 Approved "Centriolar satellite,Cytosol" NA NA "Cluster 58: Brain - Synaptic function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 62: Horizontal cells - Visual perception" "Centriolar satellite, Cytosol" "HPA005442: AB_1079210" "unprognostic (1.19e-1)" "unprognostic (2.17e-3)" "unprognostic (7.31e-2)" "prognostic unfavorable (4.97e-4)" "unprognostic (1.65e-1)" "unprognostic (4.74e-3)" "unprognostic (2.32e-2)" "unprognostic (1.82e-1)" "unprognostic (2.11e-1)" "unprognostic (3.09e-2)" "unprognostic (2.06e-2)" "unprognostic (2.60e-1)" "unprognostic (2.54e-1)" "unprognostic (3.83e-2)" "unprognostic (1.96e-1)" "unprognostic (1.74e-3)" "unprognostic (3.90e-2)" 0.2 12.4 54.0 1.1 55.6 0.0 0.1 22.4 113.6 0.1 0.0 2.2 0.7 0.3 0.8 0.0 0.2 0.0 13.7 71.8 25.0 0.2 0.4 0.3 0.0 115.0 47.4 0.7 34.1 0.4 42.1 0.0 107.7 5.4 0.5 58.4 0.2 0.2 0.2 1.0 0.8 0.3 10.2 0.4 2.6 11.2 53.9 0.4 0.9 0.1 0.0 0.1 0.6 99.6 0.0 0.2 1.8 62.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 1.1 0.0 3.5 0.4 1.4 0.6 146.0 0.0 0.0 8.4 10.5 0.0 0.0 0.0 0.0 0.0 0.8 0.1 0.0 0.0 0.0 0.0 0.0 0.0 14.4 0.3 0.0 2.5 0.3 0.0 8.8 0.0 0.0 0.0 0.6 1.2 0.0 0.0 276.0 52.0 0.0 0.8 0.0 0.4 0.4 0.0 2.0 0.0 1.3 0.4 0.0 0.2 0.1 0.0 1.1 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 54.0 55.6 22.4 113.6 71.8 25.0 115.0 47.4 107.7 10.2 53.9 99.6 0.0 0.0 0.0 50.9 0.0 0.9 0.1 0.0 0.0 393.8 0.1 0.3 16.8 0.0 0.0 0.0 419.1 0.0 0.0 0.1 0.0 0.5 2.2 1.1 0.2 1.2 34.2 0.0 57.6 25.1 0.0 2.9 4.1 5.0 0.0 1.5 0.0 0.4 0.1 536.7 72.4 0.8 8.2 0.0 0.4 4.1 0.9 0.1 17.8 9.4 0.0 116.4 0.0 18.1 50.3 14.6 0.0 0.4 0.0 10.4 0.0 0.3 0.0 176.8 0.0 0.0 1.0 46.2 20.5 0.0 0.0 0.0 0.0 3.8 0.1 0.5 KIF1B "CMT2, CMT2A, HMSNII, KIAA0591, KLP" ENSG00000054523 "Kinesin family member 1B" O60333 1 10210570-10381603 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" Apoptosis "Motor protein" "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 103.6;retina: 127.4;skeletal muscle: 202.3;tongue: 150.9" "Cell type enhanced" "Detected in many" "Astrocytes: 413.9;Cone photoreceptor cells: 579.6;Excitatory neurons: 297.4;Inhibitory neurons: 281.6;Oligodendrocytes: 521.3;Rod photoreceptor cells: 389.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "eosinophil: 5.5" "Lineage enriched" "Detected in many" 4 "granulocytes: 5.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB015177 Approved Approved "Nucleoli fibrillar center,Microtubules" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 54: Non-specific - Microtubule organization" "Cluster 12: NES - Nervous system development" "Cluster 9: Photoreceptor cells - Phototransduction" Microtubules "Nucleoli fibrillar center" "CAB015177: AB_2296564" "unprognostic (1.30e-1)" "unprognostic (6.88e-2)" "unprognostic (4.96e-2)" "unprognostic (9.82e-3)" "unprognostic (7.15e-2)" "unprognostic (1.37e-1)" "unprognostic (1.66e-2)" "unprognostic (1.13e-1)" "unprognostic (2.67e-1)" "unprognostic (8.72e-2)" "unprognostic (3.26e-2)" "unprognostic (1.20e-1)" "prognostic favorable (2.91e-6)" "unprognostic (1.51e-1)" "unprognostic (3.46e-2)" "unprognostic (1.10e-1)" "unprognostic (9.33e-3)" 11.1 14.8 64.1 8.2 73.5 16.0 12.4 68.4 67.0 11.0 0.0 16.7 9.5 15.5 6.8 18.3 10.5 10.3 29.7 65.9 58.2 14.6 12.1 11.0 4.2 74.7 61.6 15.7 13.2 20.5 12.6 10.2 78.1 11.9 9.2 127.4 12.8 9.3 202.3 14.2 10.6 15.2 44.0 7.3 9.4 19.7 60.4 4.8 10.9 150.9 5.0 11.6 12.5 103.6 25.0 17.7 81.3 31.8 22.0 24.6 7.0 24.0 16.6 24.8 25.0 19.5 12.2 3.6 23.4 38.9 13.2 17.7 58.9 18.8 34.2 35.1 19.3 14.7 25.8 23.0 17.6 5.2 4.5 19.0 18.8 42.3 26.7 18.0 31.1 15.4 16.6 14.4 27.7 7.5 5.9 5.2 17.9 10.9 13.0 24.6 47.2 6.6 10.3 12.2 55.3 27.0 33.8 16.1 32.9 33.5 11.5 7.0 36.4 29.1 18.4 33.0 23.1 7.8 13.9 7.7 25.1 15.8 14.9 2.3 1.0 5.5 0.6 0.9 0.3 0.5 0.6 0.7 0.7 0.5 0.4 0.4 4.7 0.6 1.2 0.5 0.8 0.5 64.1 73.5 68.4 67.0 65.9 58.2 74.7 61.6 78.1 44.0 60.4 103.6 38.3 60.9 21.6 413.9 9.3 50.9 24.5 15.2 25.0 248.2 33.6 26.5 120.0 14.3 18.1 22.0 579.6 6.9 17.5 26.4 0.0 18.8 85.8 34.6 41.8 39.8 28.8 4.2 297.4 18.1 6.1 42.6 22.4 63.1 7.0 104.6 20.3 37.6 22.1 139.7 281.6 17.7 20.3 22.0 43.5 48.4 18.6 36.8 51.6 75.9 19.5 56.1 6.2 238.8 521.3 23.8 23.4 20.7 21.1 25.8 31.7 14.2 19.9 389.3 19.7 85.4 42.3 37.3 37.7 40.8 59.1 6.7 14.4 63.0 21.3 20.8 KIF21A "FEOM1, FLJ20052" ENSG00000139116 "Kinesin family member 21A" Q7Z4S6 12 39293228-39443390 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Motor protein" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 70.3;retina: 77.6" "Cell type enhanced" "Detected in many" "Bipolar cells: 308.6;Cone photoreceptor cells: 308.6;Inhibitory neurons: 221.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "gdT-cell: 7.1;MAIT T-cell: 3.4;memory CD4 T-cell: 4.4;memory CD8 T-cell: 7.3;naive CD8 T-cell: 4.8;NK-cell: 3.0;T-reg: 2.2" "Group enriched" "Detected in many" 9 "NK-cells: 3.0;T-cells: 7.3" "Cell line enriched" "Detected in many" 4 "SH-SY5Y: 187.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022079, HPA058432" Enhanced Enhanced "Plasma membrane,Cytosol" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 77: Retina - Visual perception" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 56: Bipolar cells - Visual perception" "Plasma membrane" Cytosol "CAB022079: , HPA058432: AB_2683717" "unprognostic (1.08e-3)" "unprognostic (3.40e-1)" "unprognostic (2.06e-2)" "unprognostic (7.67e-2)" "unprognostic (1.13e-1)" "unprognostic (3.09e-1)" "unprognostic (2.24e-3)" "unprognostic (7.77e-2)" "unprognostic (3.17e-2)" "unprognostic (4.56e-3)" "unprognostic (1.36e-1)" "unprognostic (1.73e-2)" "prognostic favorable (8.07e-8)" "unprognostic (4.05e-2)" "unprognostic (1.66e-1)" "unprognostic (2.14e-1)" "unprognostic (2.34e-2)" 6.5 12.1 37.4 3.9 40.0 0.9 6.2 41.4 51.2 12.3 8.0 11.9 9.0 9.2 5.5 20.9 33.7 6.1 19.2 38.2 55.7 26.5 20.5 5.9 2.9 67.4 46.6 4.5 13.2 16.6 16.0 5.7 70.3 11.2 13.1 77.6 23.9 3.1 15.3 12.7 10.3 8.7 39.3 6.5 12.5 12.5 46.5 2.2 8.8 9.5 5.3 5.9 11.4 44.3 18.5 23.2 31.8 13.7 6.0 3.0 25.4 4.5 2.2 5.9 4.1 42.2 22.4 0.0 14.1 1.9 9.4 16.0 18.5 11.2 5.4 36.1 14.7 0.2 40.6 38.6 4.6 31.0 0.1 2.0 24.4 7.4 35.3 13.4 7.7 7.8 35.4 36.9 4.8 11.1 4.0 0.0 42.8 0.0 20.0 0.1 0.0 21.1 22.3 30.1 43.0 187.6 17.7 27.7 10.8 32.1 32.2 3.9 5.6 3.4 13.7 1.1 13.1 16.7 6.1 0.0 8.1 4.4 2.9 0.0 0.0 0.0 7.1 0.0 3.4 0.5 4.4 7.3 0.0 0.0 1.0 4.8 0.1 3.0 0.0 0.0 2.2 1.0 37.4 40.0 41.4 51.2 38.2 55.7 67.4 46.6 70.3 39.3 46.5 44.3 4.1 38.5 17.5 205.7 5.3 18.5 25.1 25.9 4.6 308.6 10.9 11.0 121.9 22.8 53.9 12.9 308.6 15.3 36.2 30.0 9.8 27.8 108.4 78.1 30.2 5.5 24.0 2.5 189.9 41.3 100.8 17.2 36.2 27.7 13.4 92.7 12.8 44.2 3.8 138.0 221.0 28.7 22.4 2.5 2.2 79.9 3.1 2.4 14.2 23.4 7.8 112.3 25.7 124.1 160.3 37.2 20.0 2.6 30.7 37.5 20.7 53.3 193.9 186.1 0.0 26.1 17.4 57.2 24.0 30.5 30.7 59.1 33.5 17.7 29.3 21.7 KIF3B "FLA8, KIAA0359, KLP-11" ENSG00000101350 "Kinesin family member 3B" O15066 20 32277651-32335011 "Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Motor protein" "Ciliopathy, Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 106.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007119 Approved NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 39: CACO-2 - Unknown function" "Cluster 9: Photoreceptor cells - Phototransduction" "HPA007119: AB_1852498" "unprognostic (1.74e-2)" "unprognostic (2.25e-1)" "unprognostic (5.14e-2)" "unprognostic (1.84e-1)" "unprognostic (2.73e-1)" "unprognostic (2.89e-1)" "unprognostic (1.49e-2)" "unprognostic (2.14e-1)" "unprognostic (9.01e-3)" "unprognostic (9.30e-2)" "unprognostic (1.41e-1)" "unprognostic (1.18e-1)" "prognostic favorable (1.44e-12)" "unprognostic (2.41e-2)" "unprognostic (2.68e-1)" "unprognostic (5.11e-2)" "unprognostic (4.42e-2)" 12.2 14.0 25.1 11.1 25.4 8.5 12.1 18.2 25.5 14.5 34.6 18.7 19.9 11.6 17.5 7.7 20.5 14.9 8.1 30.3 20.8 35.4 17.8 12.9 11.5 20.8 22.7 13.5 23.0 46.7 17.3 8.5 18.8 11.7 19.0 30.8 11.1 10.9 8.4 7.8 24.1 12.1 22.4 9.9 17.6 22.2 26.9 8.2 19.2 5.6 11.9 11.4 8.5 21.4 49.9 33.2 22.6 29.1 29.3 46.3 23.0 24.2 33.7 28.7 22.4 56.9 26.7 26.7 28.4 45.8 40.8 31.4 29.3 35.8 36.3 12.7 13.3 23.1 25.6 28.2 18.6 19.6 16.9 28.6 25.2 49.5 19.5 23.5 23.7 10.7 14.5 10.4 23.4 22.8 9.1 8.9 12.2 26.5 28.8 8.3 37.1 9.7 29.2 36.1 37.0 31.1 63.2 16.7 24.7 18.9 36.8 15.1 28.9 53.4 36.4 31.4 30.2 17.3 26.5 13.5 53.2 33.7 22.2 0.7 1.5 1.9 3.2 2.2 2.6 3.2 2.4 3.0 0.9 3.1 1.4 2.2 1.6 1.4 3.2 1.5 2.0 1.0 25.1 25.4 18.2 25.5 30.3 20.8 20.8 22.7 18.8 22.4 26.9 21.4 10.6 22.4 23.4 11.1 12.2 6.6 8.5 12.8 13.6 32.4 14.1 10.7 9.2 40.0 15.0 12.9 106.3 8.1 10.8 67.9 3.9 34.4 67.1 48.5 21.3 16.8 39.4 6.3 31.4 39.1 6.3 14.2 20.9 31.3 8.2 13.7 13.9 28.7 8.1 32.0 37.7 26.3 14.2 7.7 5.5 88.2 13.4 9.0 0.0 8.4 10.9 19.2 8.2 10.1 11.4 32.4 33.4 20.3 16.3 12.1 82.4 23.7 59.1 63.6 0.0 21.0 11.7 33.4 7.4 10.7 5.1 6.6 12.4 17.6 27.3 9.3 KIF5A "D12S1889, MY050, NKHC, SPG10" ENSG00000155980 "Kinesin family member 5A" Q12840 12 57546026-57586633 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Motor protein" "Amyotrophic lateral sclerosis, Disease variant, Epilepsy, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 27 "brain: 1628.2;choroid plexus: 951.3" "Cell type enhanced" "Detected in some" "Bipolar cells: 40.7;Early spermatids: 12.2;Endometrial stromal cells: 12.9;Excitatory neurons: 28.4;Horizontal cells: 26.9;Inhibitory neurons: 21.7;Late spermatids: 15.2;Rod photoreceptor cells: 11.3" "Cancer enriched" "Detected in some" 5 "glioma: 26.4" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HDLM-2: 33.2;K-562: 15.3;NTERA-2: 17.7;SCLC-21H: 34.4;U-87 MG: 14.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004469, HPA073448" Enhanced Approved "Nucleoplasm,Mitotic spindle,Cytosol" Yes No "Cluster 32: T-cells - Unknown function" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 44: HDLM-2 - Immune response" "Cluster 56: Bipolar cells - Visual perception" "Nucleoplasm, Cytosol" "Mitotic spindle" "HPA004469: AB_1079212, HPA073448: AB_2686601" "unprognostic (7.94e-2)" "unprognostic (4.95e-3)" "unprognostic (3.87e-1)" "unprognostic (3.34e-3)" "unprognostic (7.12e-2)" "unprognostic (4.22e-2)" "unprognostic (3.22e-5)" "unprognostic (2.82e-1)" "unprognostic (2.01e-1)" "unprognostic (1.52e-2)" "prognostic favorable (5.23e-4)" "unprognostic (7.61e-2)" "unprognostic (2.26e-4)" "unprognostic (4.75e-2)" "unprognostic (1.46e-1)" "unprognostic (4.12e-1)" "unprognostic (1.51e-1)" 0.4 10.6 1198.6 4.6 1243.7 4.2 0.5 1056.4 1628.2 2.5 951.3 4.5 3.6 3.8 1.4 1.4 0.6 0.7 0.6 1242.7 1056.4 0.8 0.2 0.8 0.7 1103.5 1046.7 0.6 2.6 9.0 21.3 0.1 1113.3 0.9 1.9 48.0 1.1 0.6 0.3 1.1 2.5 2.0 1002.7 0.8 1.3 4.8 1052.3 0.1 2.3 0.1 0.4 0.5 1.5 1313.2 0.5 0.1 7.2 5.7 0.0 0.0 0.6 1.4 1.3 2.2 3.5 1.2 0.2 3.2 0.4 1.9 1.3 0.8 3.8 0.1 2.5 33.2 4.1 0.5 1.8 7.0 1.9 1.5 1.3 1.0 0.4 1.6 0.1 0.5 0.5 2.8 15.3 9.4 0.0 0.6 0.8 0.0 17.7 0.0 0.0 0.5 0.2 0.3 1.1 0.5 34.4 9.1 0.0 1.6 0.0 2.0 0.9 0.2 0.9 0.6 5.3 1.1 2.1 5.3 7.7 1.9 14.5 0.1 0.6 0.2 0.4 0.1 1.0 0.5 1.6 0.7 0.7 1.2 0.3 0.5 0.9 2.2 1.1 0.3 1.1 0.3 1.0 0.4 1198.6 1243.7 1056.4 1628.2 1242.7 1056.4 1103.5 1046.7 1113.3 1002.7 1052.3 1313.2 0.1 0.0 0.0 2.9 0.1 0.0 0.1 0.0 0.0 40.7 0.1 0.9 2.0 0.0 0.0 0.0 2.1 0.0 0.2 0.0 0.0 0.0 12.2 0.5 12.9 0.7 0.0 0.4 28.4 0.2 0.0 0.3 0.0 0.3 0.0 0.1 0.0 0.0 0.1 26.9 21.7 0.2 0.0 0.0 0.2 15.2 0.0 0.1 0.0 0.0 0.0 6.4 0.0 8.5 3.9 0.2 0.0 0.4 0.0 0.0 0.0 0.0 0.0 11.3 0.0 0.0 0.7 3.3 7.9 0.0 0.1 0.0 0.3 0.0 0.1 0.1 KITLG "DFNA69, FPH2, Kitl, KL-1, MGF, SCF, SF, SLF" ENSG00000049130 "KIT ligand" P21583 12 88492793-88580851 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Cell adhesion" "Growth factor" "Cancer-related genes, Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 83.6;Collecting duct cells: 69.9;Excitatory neurons: 46.5;Inhibitory neurons: 61.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CACO-2: 299.8;SK-BR-3: 118.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA070395 Approved Approved Vesicles "Intracellular and membrane" NA NA 260000 "Cluster 46: Fibroblasts - ECM organization" "Cluster 39: CACO-2 - Unknown function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles "HPA070395: AB_2686264" "unprognostic (7.13e-2)" "unprognostic (1.90e-1)" "unprognostic (5.00e-2)" "unprognostic (2.05e-1)" "unprognostic (2.70e-1)" "unprognostic (1.93e-2)" "prognostic unfavorable (4.01e-4)" "unprognostic (2.22e-3)" "unprognostic (5.61e-3)" "unprognostic (7.89e-2)" "unprognostic (5.47e-3)" "unprognostic (5.03e-2)" "prognostic favorable (5.81e-7)" "unprognostic (7.15e-2)" "unprognostic (1.23e-1)" "unprognostic (1.15e-1)" "unprognostic (1.54e-2)" 13.2 3.9 2.3 8.2 3.5 0.3 10.6 0.2 3.1 12.9 1.2 18.7 9.6 15.1 2.8 14.3 4.0 18.5 7.0 2.9 0.3 16.0 2.3 31.6 3.3 0.0 2.5 6.0 3.7 3.7 0.2 15.0 0.0 15.1 22.6 2.3 8.8 14.8 3.1 7.1 11.6 18.8 0.3 3.5 17.4 6.3 5.2 5.1 5.9 14.4 10.4 12.3 1.3 6.2 14.3 7.1 7.1 0.9 29.0 61.5 0.0 77.6 60.1 13.5 6.4 299.8 11.0 0.0 2.2 73.3 14.9 49.5 11.5 20.1 14.2 0.1 9.5 0.0 9.5 2.6 4.4 1.9 0.0 53.5 20.6 41.6 26.8 6.3 17.9 0.0 0.0 0.3 6.8 2.5 0.2 0.0 4.8 17.7 17.9 0.0 12.6 0.0 25.0 6.5 2.3 4.8 18.5 118.9 2.2 6.5 57.2 4.3 10.0 60.7 7.4 69.0 6.8 0.0 0.0 0.0 8.4 0.2 5.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 3.5 0.2 3.1 2.9 0.3 0.0 2.5 0.0 0.3 5.2 6.2 42.5 19.2 38.3 9.4 0.5 13.5 11.2 7.5 83.6 2.7 12.2 8.1 4.4 1.5 16.5 69.9 0.0 0.1 0.0 12.0 1.9 4.4 0.4 3.1 6.8 43.1 9.5 0.0 46.5 18.2 0.1 34.5 43.3 3.4 0.0 2.1 5.0 0.4 1.2 21.9 61.4 8.5 18.3 3.2 5.7 0.9 14.0 1.9 12.4 18.7 0.0 0.3 0.0 3.0 0.6 8.7 3.0 3.8 1.4 11.2 2.3 1.4 9.8 1.2 13.1 2.2 27.2 0.2 0.5 18.5 5.3 0.0 1.0 4.4 14.7 3.2 KIZ "C20orf19, HT013, NCRNA00153, PLK1S1" ENSG00000088970 "Kizuna centrosomal protein" Q2M2Z5 20 21125983-21246622 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 203.0;Late spermatids: 127.3;Oligodendrocyte precursor cells: 198.5;Oligodendrocytes: 166.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Hep G2: 92.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 43: Testis - Unknown function" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 34: Spermatids - Unknown function" "unprognostic (1.78e-1)" "unprognostic (1.77e-2)" "unprognostic (1.56e-1)" "prognostic favorable (4.45e-4)" "unprognostic (2.05e-2)" "unprognostic (5.71e-2)" "unprognostic (1.90e-1)" "unprognostic (9.71e-3)" "unprognostic (3.68e-2)" "unprognostic (1.44e-2)" "unprognostic (1.43e-3)" "unprognostic (1.64e-1)" "prognostic unfavorable (4.11e-8)" "unprognostic (4.82e-2)" "unprognostic (2.20e-1)" "unprognostic (4.94e-2)" "unprognostic (2.12e-1)" 17.6 9.8 22.7 7.2 30.2 10.7 15.4 27.7 29.2 32.5 20.2 72.2 15.1 27.0 11.2 8.0 19.8 12.6 17.5 21.8 25.1 14.4 11.3 9.8 10.6 30.7 27.9 35.5 24.3 14.6 23.3 8.9 31.6 19.3 13.2 20.2 13.6 23.8 29.4 14.9 17.8 17.1 25.2 13.6 16.3 45.4 28.2 16.6 26.9 14.6 11.1 36.5 22.9 36.9 7.5 5.9 7.9 7.5 27.3 37.3 10.9 10.6 17.9 8.8 10.4 6.4 6.1 14.0 8.9 12.5 9.3 6.2 8.0 22.4 12.2 7.9 9.2 11.3 11.2 92.8 13.8 13.9 9.2 28.2 45.8 8.6 28.2 20.8 8.3 23.3 18.6 18.8 7.6 6.4 14.7 18.0 10.8 13.5 5.9 9.2 22.5 13.7 9.7 13.0 10.7 20.9 21.4 11.4 22.4 17.9 7.3 27.1 7.8 9.2 8.0 7.2 7.7 18.9 13.7 10.5 4.5 15.5 8.4 4.6 5.0 12.5 10.4 5.6 12.2 11.7 10.9 10.5 3.1 11.4 11.5 12.6 16.5 8.4 4.2 7.3 14.3 5.0 22.7 30.2 27.7 29.2 21.8 25.1 30.7 27.9 31.6 25.2 28.2 36.9 11.0 0.0 10.0 41.1 22.6 0.0 9.2 0.0 9.6 35.4 7.6 10.7 16.6 12.8 5.0 18.4 37.5 7.8 16.6 4.4 7.9 5.0 203.0 24.6 16.0 8.7 11.4 11.6 76.4 7.1 7.6 19.4 6.1 9.8 8.8 18.9 7.5 5.2 4.0 50.5 99.0 9.1 0.0 6.0 0.0 127.3 38.8 6.1 0.0 27.2 7.6 28.1 16.5 198.5 166.8 3.5 5.6 31.6 25.9 4.0 21.7 5.9 10.2 35.1 13.1 20.8 11.4 78.3 37.4 7.7 0.0 4.2 17.8 12.9 9.7 10.9 KLC2 FLJ12387 ENSG00000174996 "Kinesin light chain 2" Q9H0B6 11 66257294-66267860 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Motor protein" "Hereditary spastic paraplegia, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Horizontal cells: 55.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040416, HPA040434" Approved Supported "Nucleoplasm,Plasma membrane,Mitochondria,Cytosol" NA NA "Cluster 24: B-cells - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 62: Horizontal cells - Visual perception" "Plasma membrane, Cytosol" "Nucleoplasm, Mitochondria" "HPA040416: AB_10795524, HPA040434: AB_10795367" "unprognostic (1.29e-1)" "unprognostic (4.95e-3)" "unprognostic (2.99e-1)" "unprognostic (3.24e-2)" "unprognostic (2.33e-1)" "prognostic unfavorable (3.16e-4)" "unprognostic (2.43e-3)" "unprognostic (2.45e-2)" "unprognostic (6.27e-3)" "unprognostic (1.60e-1)" "unprognostic (3.49e-2)" "unprognostic (1.64e-3)" "unprognostic (4.57e-3)" "unprognostic (1.96e-2)" "unprognostic (1.81e-1)" "unprognostic (1.72e-2)" "unprognostic (8.08e-2)" 15.2 18.0 18.8 9.5 25.4 3.6 15.9 33.0 78.1 27.3 0.0 28.5 9.8 27.1 6.3 18.2 21.6 8.9 32.1 26.6 12.7 22.4 8.2 18.9 9.1 39.8 10.8 24.6 15.5 15.2 48.3 7.2 37.0 28.7 4.7 28.4 15.9 16.0 57.8 18.3 16.3 11.2 5.7 13.7 20.2 32.2 23.1 25.1 17.7 14.2 6.4 27.2 21.7 35.8 49.4 58.2 28.3 16.9 16.9 13.5 21.9 34.1 24.2 34.2 26.1 31.9 14.3 21.3 31.9 25.6 43.9 40.7 29.3 33.2 11.4 35.7 37.2 4.4 48.0 22.4 32.1 9.9 22.7 13.5 42.7 40.1 32.8 22.0 16.1 26.2 24.1 29.0 27.8 69.2 56.8 15.0 27.8 14.2 49.2 21.4 14.6 30.1 27.2 27.4 76.3 37.5 24.6 22.1 41.3 15.7 36.3 6.7 26.8 55.5 49.8 68.2 45.5 30.7 27.4 11.9 39.3 6.7 22.9 0.0 0.2 0.5 2.4 0.1 3.1 1.9 1.1 1.6 0.3 3.2 1.1 1.4 0.3 1.3 0.2 2.1 0.3 1.1 18.8 25.4 33.0 78.1 26.6 12.7 39.8 10.8 37.0 5.7 23.1 35.8 4.0 3.2 1.5 8.8 8.9 8.9 9.2 11.1 7.4 34.4 10.1 7.2 2.4 7.2 5.5 12.9 12.5 9.9 5.1 3.1 13.7 14.8 10.1 7.7 6.2 5.2 37.1 0.8 20.7 8.2 18.2 6.5 13.7 9.7 0.0 8.6 3.9 2.3 3.1 55.5 19.0 7.2 18.3 3.2 4.0 4.6 8.7 2.8 12.4 5.6 6.3 14.6 4.1 4.0 6.2 19.1 4.9 13.9 9.1 18.2 3.9 10.3 7.3 35.2 0.0 9.5 13.3 26.2 29.8 8.9 9.7 12.7 8.2 3.4 4.9 8.5 KLHL7 "KLHL6, RP42, SBBI26" ENSG00000122550 "Kelch like family member 7" Q8IXQ5 7 23105758-23177914 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Ubl conjugation pathway" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 50.8" "Cell type enhanced" "Detected in all" "Early spermatids: 560.6;Late spermatids: 242.7;Oligodendrocyte precursor cells: 168.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029491, HPA029492" Uncertain Enhanced "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 43: Testis - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 29: Early spermatids - Spermatogenesis" "Nucleoplasm, Cytosol" "Plasma membrane" "HPA029491: AB_10599605, HPA029492: AB_10600881" "unprognostic (1.24e-2)" "unprognostic (4.45e-1)" "unprognostic (1.77e-1)" "unprognostic (4.55e-2)" "unprognostic (1.29e-2)" "unprognostic (1.65e-2)" "prognostic unfavorable (7.96e-4)" "unprognostic (3.78e-1)" "unprognostic (6.10e-2)" "unprognostic (6.41e-3)" "unprognostic (1.30e-1)" "unprognostic (1.51e-1)" "prognostic favorable (8.98e-5)" "unprognostic (2.46e-2)" "unprognostic (3.55e-3)" "unprognostic (3.23e-2)" "unprognostic (2.27e-2)" 9.5 18.8 12.8 7.0 13.3 12.4 13.0 16.3 15.9 10.5 12.1 9.2 7.8 11.5 12.2 9.0 9.7 9.7 50.8 12.5 13.1 11.9 10.4 7.7 8.3 12.6 12.7 11.8 7.7 10.8 7.3 8.6 12.3 10.1 7.9 14.9 8.5 8.1 9.1 10.9 6.9 10.5 12.2 8.0 6.3 42.2 13.4 12.4 9.2 9.7 9.1 8.7 9.4 14.7 24.7 20.7 55.7 66.3 26.8 23.2 20.3 21.3 31.5 30.7 35.6 25.3 17.5 24.1 16.8 26.2 50.5 26.2 21.5 15.0 25.8 6.4 15.5 15.9 16.7 32.9 20.0 32.5 12.0 20.7 19.1 35.2 28.8 24.2 39.6 29.4 28.3 25.5 50.7 28.4 27.3 51.3 77.0 16.7 24.5 23.7 31.2 22.2 29.2 21.0 33.5 32.5 46.2 22.7 23.3 33.9 18.9 16.9 17.0 25.7 26.6 56.9 25.7 39.9 35.3 58.6 17.0 33.8 31.5 44.1 15.3 67.2 13.0 17.9 13.7 9.2 13.8 12.3 11.1 11.9 10.1 10.0 14.4 9.5 15.8 8.0 16.7 12.6 12.8 13.3 16.3 15.9 12.5 13.1 12.6 12.7 12.3 12.2 13.4 14.7 12.1 22.4 5.5 45.7 13.0 23.6 18.2 13.0 18.2 23.7 12.3 13.5 101.2 8.6 11.3 9.2 29.2 20.7 14.4 5.7 11.7 17.7 560.6 18.3 16.7 15.8 10.8 25.6 74.5 17.6 27.1 19.8 10.2 13.2 21.5 16.3 13.2 7.0 19.7 37.0 75.2 7.6 14.2 16.0 17.2 242.7 16.8 12.6 12.4 35.6 13.4 30.3 8.2 168.9 45.6 19.4 1.9 20.7 12.3 11.5 7.4 13.5 18.8 16.3 6.6 14.3 17.9 83.7 19.7 24.6 33.8 23.7 17.2 12.1 7.0 24.0 KMT2B "CXXC10, HRX2, KIAA0304, MLL1B, MLL2, MLL4, TRX2, WBP7" ENSG00000272333 "Lysine methyltransferase 2B" Q9UMN6 19 35717973-35738878 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Chromatin regulator, DNA-binding, Methyltransferase, Transferase" "Cancer-related genes, Disease variant, Dystonia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Bipolar cells: 64.5;Rod photoreceptor cells: 71.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006487 Approved Nucleoplasm,Cytosol NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 43: Testis - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 52: Non-specific - Transcription" Nucleoplasm Cytosol "HPA006487: AB_1080587" "unprognostic (1.09e-2)" "unprognostic (3.53e-2)" "unprognostic (3.41e-2)" "unprognostic (7.95e-2)" "unprognostic (9.92e-2)" "unprognostic (3.53e-3)" "unprognostic (2.33e-2)" "unprognostic (4.57e-2)" "unprognostic (7.28e-2)" "unprognostic (2.07e-2)" "unprognostic (3.13e-3)" "unprognostic (2.63e-3)" "unprognostic (9.47e-3)" "unprognostic (2.10e-1)" "unprognostic (2.37e-1)" "unprognostic (3.77e-2)" "unprognostic (2.24e-2)" 11.6 10.1 15.4 9.8 15.7 14.3 11.8 17.2 22.9 12.9 12.2 13.6 9.8 14.1 4.4 12.8 13.1 6.8 8.4 14.7 14.8 10.3 10.0 12.1 14.5 15.4 14.4 16.1 16.0 5.1 14.5 5.8 14.7 13.4 3.9 5.8 13.3 5.8 16.1 18.8 14.5 4.5 12.4 15.6 12.7 22.5 15.9 9.3 16.6 5.0 6.8 12.6 12.0 16.0 16.7 36.7 11.1 17.3 6.0 4.3 11.0 6.7 4.7 7.3 5.0 25.3 7.4 15.5 11.8 5.1 8.5 10.8 11.3 5.2 4.2 21.2 13.6 29.7 20.2 24.4 8.6 17.4 26.1 6.9 9.4 8.9 10.7 6.9 5.7 13.5 22.5 15.8 6.4 34.1 15.9 24.4 12.0 18.8 9.2 19.8 8.9 7.6 7.8 21.3 14.0 10.0 13.5 20.6 11.3 7.9 11.8 21.3 12.5 16.3 17.0 10.5 17.4 22.2 15.7 12.4 8.5 18.8 12.2 0.3 0.4 0.4 1.0 0.1 0.5 0.4 0.6 0.7 0.3 0.7 0.6 0.9 1.8 0.5 0.2 2.1 0.8 0.4 15.4 15.7 17.2 22.9 14.7 14.8 15.4 14.4 14.7 12.4 15.9 16.0 24.6 9.6 15.4 13.7 18.6 12.7 10.0 6.2 9.6 64.5 16.1 14.6 9.2 8.6 6.3 9.2 52.1 6.5 27.4 25.2 0.0 6.4 2.8 17.9 31.6 15.6 20.3 7.4 11.7 7.7 6.1 12.4 27.5 26.0 5.1 30.5 11.0 11.2 8.4 35.3 11.8 14.1 6.1 11.8 7.1 4.7 8.1 13.4 5.4 7.5 9.5 25.7 19.6 7.5 10.0 8.4 16.7 12.4 17.9 19.6 13.9 5.0 6.7 71.2 0.0 25.0 17.3 26.5 38.5 11.9 12.9 9.4 20.6 30.7 16.3 14.8 KRT12 K12 ENSG00000187242 "Keratin 12" Q99456 17 40861303-40867223 "Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Corneal dystrophy, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in single" "intestine: 1.0" "Group enriched" "Detected in some" 5 "Distal enterocytes: 3.9;Paneth cells: 12.8" "Low cancer specificity" "Detected in single" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA055217, HPA055835" Enhanced NA NA "Cluster 31: Skin - Epidermis development" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA055217: AB_2682742, HPA055835: AB_2682935" "unprognostic (1.89e-1)" "unprognostic (2.40e-2)" "unprognostic (1.01e-1)" "unprognostic (4.82e-1)" "unprognostic (2.19e-1)" "unprognostic (2.04e-1)" "unprognostic (1.74e-2)" "unprognostic (5.52e-2)" "unprognostic (9.41e-3)" "unprognostic (3.49e-1)" "unprognostic (1.73e-1)" "unprognostic (3.94e-3)" "unprognostic (2.01e-2)" "unprognostic (1.27e-1)" "unprognostic (2.60e-4)" "unprognostic (6.31e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.9 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 3.9 0.0 0.0 1.6 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 12.8 0.0 0.0 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 KRT3 "CK3, K3" ENSG00000186442 "Keratin 3" P12035 12 52789685-52796117 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Corneal dystrophy, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "esophagus: 3.0;salivary gland: 10.0" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "cervical cancer: 0.7;head and neck cancer: 2.1" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "HaCaT: 9.4;HMC-1: 5.6" "Region enhanced" "Detected in single" "cerebral cortex: 1.7" NA NA 280000000 "Cluster 24: Salivary gland - Salivary secretion" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 61: Squamous epithelial cells - Keratinization" "unprognostic (1.03e-1)" "unprognostic (2.68e-2)" "unprognostic (2.42e-2)" "unprognostic (2.75e-1)" "unprognostic (9.68e-2)" "unprognostic (1.54e-1)" "unprognostic (1.45e-1)" "unprognostic (1.54e-2)" "unprognostic (3.89e-2)" "unprognostic (2.54e-1)" "unprognostic (3.08e-2)" "unprognostic (1.73e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 1.1 0.0 0.0 0.6 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.3 0.8 0.0 0.0 0.0 0.0 L1CAM "CD171, HSAS, HSAS1, MASA, MIC5, S10, SPG1" ENSG00000198910 "L1 cell adhesion molecule" P32004 X 153861514-153886173 "CD markers, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion, Differentiation, Neurogenesis" "Developmental protein" "Disease variant, Hereditary spastic paraplegia, Hirschsprung disease, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 42.8;intestine: 48.5" "Cell type enhanced" "Detected in some" "Collecting duct cells: 84.6;Excitatory neurons: 23.7;Horizontal cells: 33.7;Inhibitory neurons: 23.3;Melanocytes: 44.4" "Cancer enhanced" "Detected in many" "melanoma: 34.1" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ hTERT+: 372.4;BJ hTERT+ SV40 Large T+ RasG12V: 200.8;HeLa: 258.1;RH-30: 162.6;RPTEC TERT1: 218.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB010896 Enhanced Approved "Nucleoplasm,Plasma membrane" NA NA 67000000 "Cluster 24: B-cells - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 62: Horizontal cells - Visual perception" "Nucleoplasm, Plasma membrane" "CAB010896: AB_609903" "unprognostic (1.33e-3)" "unprognostic (3.43e-2)" "unprognostic (2.75e-1)" "prognostic unfavorable (8.51e-10)" "unprognostic (2.04e-2)" "prognostic unfavorable (3.81e-4)" "unprognostic (9.44e-2)" "prognostic unfavorable (2.36e-6)" "unprognostic (1.13e-1)" "unprognostic (9.12e-2)" "unprognostic (8.52e-3)" "unprognostic (8.02e-2)" "prognostic unfavorable (1.17e-4)" "unprognostic (3.07e-1)" "unprognostic (6.31e-2)" "unprognostic (1.69e-1)" "unprognostic (7.47e-3)" 3.5 27.2 20.4 7.6 23.0 0.5 2.1 23.0 42.8 8.4 0.0 48.5 4.2 2.4 2.1 4.4 3.4 2.4 12.1 12.6 42.4 18.5 0.9 0.6 3.2 9.0 2.5 1.3 2.2 0.1 14.4 0.6 6.1 8.3 4.7 15.7 4.8 9.0 0.9 9.2 13.0 5.4 0.0 0.9 11.3 0.8 3.2 0.7 2.5 2.1 1.8 6.1 9.6 13.2 95.2 7.2 27.6 0.2 0.0 0.0 11.8 131.6 372.4 123.6 200.8 37.8 1.0 0.0 121.8 0.9 103.2 3.9 3.5 2.3 64.1 0.3 1.0 0.0 258.1 6.1 0.4 0.3 20.4 0.9 1.6 18.7 12.9 0.2 0.1 0.1 0.3 0.3 0.6 127.9 0.4 2.6 6.5 0.4 4.7 0.2 162.6 0.9 218.4 1.9 81.4 53.0 73.4 64.2 54.1 61.0 6.7 1.7 0.3 0.1 52.6 5.8 63.7 1.1 1.6 1.0 0.9 1.1 105.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 20.4 23.0 23.0 42.8 12.6 42.4 9.0 2.5 6.1 0.0 3.2 13.2 0.4 0.0 0.0 2.6 1.3 1.1 0.1 0.6 3.4 11.6 0.0 0.4 1.2 0.0 0.0 84.6 4.2 0.3 0.1 0.0 0.0 0.5 0.0 0.3 0.1 1.9 0.0 0.0 23.7 0.0 0.2 1.3 0.0 0.6 0.0 0.0 1.4 0.0 0.1 33.7 23.3 0.0 0.0 0.0 1.1 0.0 0.9 0.3 44.4 5.6 0.0 1.5 0.0 1.5 1.7 0.0 0.0 0.0 0.1 0.1 0.0 0.3 0.1 10.4 0.0 2.2 0.6 0.4 0.1 0.0 1.3 0.1 1.5 0.0 0.0 0.1 LCA5 C6orf152 ENSG00000135338 "Lebercilin LCA5" Q86VQ0 6 79484991-79537458 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Protein transport, Transport" "Disease variant, Leber congenital amaurosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 52.6;Respiratory ciliated cells: 89.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HEL: 14.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029053, HPA029055" Supported NA NA "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 36: HEL - Hemostasis" "Cluster 49: Ciliated cells - Cilium organization" "HPA029053: AB_10602020, HPA029055: AB_2672889" "unprognostic (8.96e-2)" "unprognostic (1.04e-1)" "unprognostic (3.06e-2)" "unprognostic (2.65e-1)" "unprognostic (1.13e-1)" "unprognostic (1.45e-1)" "unprognostic (6.58e-2)" "unprognostic (1.34e-3)" "unprognostic (6.83e-2)" "unprognostic (2.73e-2)" "unprognostic (4.11e-1)" "unprognostic (1.51e-1)" "prognostic unfavorable (4.69e-4)" "unprognostic (7.09e-3)" "unprognostic (1.39e-1)" "unprognostic (5.39e-2)" "unprognostic (3.21e-2)" 3.2 1.9 4.4 1.6 3.9 3.6 4.9 4.0 5.0 4.2 16.9 2.5 1.0 5.4 3.7 3.0 9.6 3.0 2.4 6.0 4.6 2.8 1.2 4.0 1.5 4.5 5.8 7.3 2.5 17.2 3.6 3.3 5.1 3.9 1.6 13.7 5.5 4.7 1.1 1.0 1.3 4.2 5.3 1.7 1.6 6.9 2.8 1.1 6.3 2.0 1.0 3.5 2.8 6.1 1.7 1.3 3.9 2.2 4.8 5.3 1.7 3.0 3.6 1.8 3.7 9.9 1.9 0.4 3.9 2.4 3.4 1.8 2.9 1.8 3.3 0.0 2.2 14.6 1.9 1.4 5.0 0.3 1.2 5.0 2.0 3.1 4.0 7.0 5.6 0.1 2.3 0.9 3.0 0.0 0.0 0.0 1.1 1.0 1.5 0.0 6.8 0.7 3.9 0.5 2.9 3.5 2.7 0.4 1.9 4.8 0.3 0.8 3.9 1.9 2.2 0.6 2.6 3.7 1.4 0.0 0.9 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.4 3.9 4.0 5.0 6.0 4.6 4.5 5.8 5.1 5.3 2.8 6.1 6.7 16.0 11.5 17.0 1.1 1.0 12.5 5.9 11.4 12.4 6.5 15.2 5.1 11.5 17.5 11.0 22.9 8.0 0.1 0.1 0.0 15.9 17.3 52.6 8.6 14.4 2.4 4.6 32.8 4.9 3.6 12.0 0.5 3.7 1.3 6.3 9.3 0.1 1.1 10.1 16.2 0.3 8.2 1.3 0.9 5.3 18.0 1.0 3.6 4.7 0.2 13.4 0.0 24.6 21.9 7.1 0.1 15.8 1.6 6.2 0.1 3.3 89.7 30.4 6.6 14.0 12.1 18.0 11.4 5.5 1.0 12.3 1.2 8.4 0.6 9.5 LEMD2 "dJ482C21.1, LEM2, NET25" ENSG00000161904 "LEM domain nuclear envelope protein 2" Q8NC56 6 33771202-33789130 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017340 Supported Supported "Nuclear membrane" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 18: Non-specific - Mitochondria" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 31: Spermatids - Spermatogenesis" "Nuclear membrane" "HPA017340: AB_2296925" "unprognostic (9.01e-2)" "unprognostic (7.99e-2)" "unprognostic (1.18e-1)" "unprognostic (4.12e-2)" "unprognostic (2.98e-1)" "unprognostic (8.29e-3)" "unprognostic (6.53e-2)" "unprognostic (5.98e-2)" "unprognostic (4.42e-2)" "unprognostic (7.03e-2)" "unprognostic (1.67e-3)" "unprognostic (2.11e-2)" "prognostic unfavorable (1.12e-5)" "unprognostic (2.43e-1)" "unprognostic (7.54e-2)" "unprognostic (3.82e-2)" "unprognostic (7.12e-2)" 40.5 45.8 46.0 35.0 47.9 63.3 39.6 53.1 50.8 52.6 44.6 45.3 31.9 44.1 29.7 50.2 45.9 30.0 46.7 43.9 44.0 51.5 49.9 51.2 45.4 52.0 47.0 53.7 54.5 39.3 56.5 38.5 47.9 51.9 30.0 29.7 43.3 31.3 37.4 51.8 50.1 30.4 46.3 70.1 44.9 45.5 47.2 46.1 53.0 28.1 41.6 43.8 44.9 54.4 36.6 40.5 67.3 66.1 37.6 40.3 50.9 39.1 59.7 48.5 50.9 30.6 37.8 33.8 53.5 55.6 136.7 62.0 39.4 52.1 34.0 35.9 36.6 12.7 45.8 40.3 78.4 26.1 42.6 44.3 96.5 51.6 88.1 80.0 52.8 43.9 36.3 38.3 42.8 30.8 48.6 64.1 39.2 53.5 23.2 31.8 27.8 28.3 52.0 50.5 47.8 37.8 23.4 74.0 52.6 68.0 49.5 70.7 24.6 67.8 26.3 36.6 46.5 49.8 43.0 24.0 26.7 40.3 83.0 1.6 1.7 3.2 2.3 1.5 2.9 2.2 2.5 2.3 1.7 2.3 2.0 2.3 1.4 1.5 2.1 2.9 2.8 1.2 46.0 47.9 53.1 50.8 43.9 44.0 52.0 47.0 47.9 46.3 47.2 54.4 19.8 3.2 9.0 16.0 17.4 10.8 13.4 7.9 14.2 18.6 10.0 7.1 10.0 8.6 5.2 9.2 18.8 24.9 18.6 24.3 1.9 9.4 24.9 7.5 10.1 18.5 5.4 8.6 14.5 6.8 36.6 12.2 15.3 10.6 12.7 16.6 12.5 7.7 17.5 43.7 17.4 17.7 6.1 14.5 12.4 44.2 10.5 13.5 12.4 14.0 9.4 14.0 13.4 14.6 18.2 13.2 20.1 16.1 11.9 14.6 14.8 6.6 7.2 13.1 19.7 12.7 15.2 24.6 7.4 8.9 10.2 29.8 15.2 12.5 15.9 13.2 LGI1 "EPITEMPIN, EPT, ETL1, IB1099" ENSG00000108231 "Leucine rich glioma inactivated 1" O95970 10 93757840-93806272 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" "Cancer-related genes, Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "brain: 39.7;choroid plexus: 44.7" "Cell type enhanced" "Detected in some" "Astrocytes: 242.9;Excitatory neurons: 57.1;Inhibitory neurons: 74.7;Oligodendrocyte precursor cells: 28.6" "Group enriched" "Detected in some" 7 "glioma: 1.8;testis cancer: 0.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 9.4;CACO-2: 2.0;NTERA-2: 6.1;SuSa: 3.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "Secreted in brain" NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 12: NES - Nervous system development" "Cluster 64: Astrocytes - Nervous system maintenance" "unprognostic (1.26e-1)" "unprognostic (4.68e-2)" "unprognostic (2.45e-2)" "unprognostic (1.01e-1)" "unprognostic (8.20e-2)" "unprognostic (1.28e-1)" "unprognostic (1.50e-1)" "unprognostic (1.24e-3)" "unprognostic (1.85e-1)" "unprognostic (4.07e-3)" "unprognostic (8.71e-2)" "unprognostic (2.21e-1)" "unprognostic (5.93e-2)" "unprognostic (4.65e-1)" 0.5 1.8 26.8 0.1 31.5 0.0 0.2 23.8 39.7 0.1 44.7 4.0 0.5 0.1 0.0 4.3 0.1 1.0 0.5 29.2 22.6 0.0 2.7 0.0 0.0 29.9 24.2 0.0 0.2 0.0 7.6 0.0 32.9 0.7 2.6 0.4 0.1 0.5 5.9 0.3 1.5 0.6 23.7 0.0 1.8 0.4 26.7 0.0 0.2 3.6 0.1 0.9 0.3 25.2 0.0 0.0 9.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 3.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 26.8 31.5 23.8 39.7 29.2 22.6 29.9 24.2 32.9 23.7 26.7 25.2 0.2 0.0 0.0 242.9 0.0 0.3 0.4 0.0 0.0 0.5 0.4 0.1 1.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 10.5 0.0 0.0 0.4 0.0 0.0 57.1 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.4 6.0 0.0 0.0 74.7 0.0 0.0 0.0 0.4 1.6 1.5 0.0 0.0 10.3 0.0 0.1 0.0 28.6 3.9 0.0 0.0 0.7 0.0 0.3 0.0 0.0 0.0 0.4 0.0 0.5 0.6 0.0 0.8 0.1 0.1 0.0 0.0 0.0 0.0 0.2 LHFPL5 "DFNB67, dJ510O8.8, MGC33835, Tmhs" ENSG00000197753 "LHFPL tetraspan subfamily member 5" Q8TAF8 6 35797206-35845397 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 18.8;epididymis: 12.4" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 13.5;Excitatory neurons: 8.0;Glandular and luminal cells: 2.8;Inhibitory neurons: 3.0" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "neutrophil: 3.3" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029421, HPA055110" Uncertain Approved Vesicles NA NA "Cluster 6: Non-specific - Transcription" "Cluster 6: Brain - Smell perception" "Cluster 20: HeLa - Mitochondria" "Cluster 54: Cardiomyocytes - Muscle contraction" Vesicles "HPA029421: , HPA055110: AB_2682697" "unprognostic (2.35e-1)" "unprognostic (6.45e-2)" "unprognostic (2.41e-2)" "unprognostic (1.22e-3)" "unprognostic (1.96e-1)" "unprognostic (1.78e-1)" "unprognostic (4.89e-3)" "unprognostic (2.96e-3)" "unprognostic (2.46e-2)" "unprognostic (1.47e-8)" "unprognostic (5.53e-2)" "unprognostic (1.70e-1)" "unprognostic (2.15e-1)" "unprognostic (1.41e-1)" 0.9 1.1 4.1 2.7 4.6 18.8 0.8 4.8 5.6 0.3 0.3 0.9 3.0 1.5 12.4 1.3 0.6 1.7 0.7 3.6 2.6 0.6 0.8 1.0 2.8 0.0 0.3 1.1 5.6 0.3 0.5 1.3 0.2 1.0 0.7 8.2 2.4 0.4 1.4 7.6 2.5 0.3 0.0 2.2 1.7 1.5 1.9 0.5 1.4 0.2 0.6 0.6 0.0 2.7 2.3 1.5 3.0 3.1 0.2 0.6 4.6 1.6 0.3 0.1 0.4 2.7 2.0 3.6 1.2 0.6 1.9 2.9 0.2 0.8 0.3 1.6 2.6 3.2 5.3 4.0 0.0 3.4 2.2 0.5 0.3 0.3 0.4 2.1 0.2 3.6 3.1 5.1 0.9 1.9 2.5 6.2 2.6 0.7 1.5 2.2 1.1 2.0 0.7 5.6 3.4 1.9 1.6 2.3 1.0 2.9 2.4 1.9 2.6 3.1 1.7 2.5 2.4 3.2 3.0 3.1 1.1 3.6 1.6 2.9 0.6 0.5 0.3 0.3 0.3 0.5 0.3 0.3 0.1 0.9 0.4 0.5 3.3 0.6 0.4 0.7 0.4 0.1 4.1 4.6 4.8 5.6 3.6 2.6 0.0 0.3 0.2 0.0 1.9 2.7 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 13.5 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.0 1.3 0.7 0.3 0.0 0.4 8.0 0.2 0.0 0.2 0.0 2.8 0.0 0.0 0.0 0.0 0.1 0.0 3.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.8 0.0 0.3 0.3 0.0 0.1 0.0 0.0 0.1 0.2 0.0 0.0 0.0 LIM2 "MP17, MP19" ENSG00000105370 "Lens intrinsic membrane protein 2" P55344 19 51379909-51387974 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Eye lens protein" "Cataract, Disease variant" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Cell type enriched" "Detected in some" 4 "NK-cells: 20.6" "Cancer enriched" "Detected in single" 40 "testis cancer: 18.3" "Not detected" "Not detected" "Immune cell enriched" "Detected in some" 7 "gdT-cell: 11.3" "Lineage enriched" "Detected in many" 7 "T-cells: 11.3" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 63: NK-cells & T-cells - Immune response" "unprognostic (5.25e-2)" "unprognostic (1.09e-3)" "unprognostic (1.21e-1)" 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.3 0.2 1.4 0.0 0.0 0.3 0.0 0.0 0.0 1.3 0.0 1.5 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 4.5 0.0 0.0 0.0 0.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 20.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.0 0.0 1.1 0.0 0.0 0.0 LITAF "FLJ38636, PIG7, SIMPLE, TP53I7" ENSG00000189067 "Lipopolysaccharide induced TNF factor" Q99732 16 11547722-11636381 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Transcription, Transcription regulation" DNA-binding "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Langerhans cells: 701.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 5 "neutrophil: 2578.1" "Lineage enriched" "Detected in all" 6 "granulocytes: 2578.1" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006960 Approved Supported "Nucleoplasm,Golgi apparatus,Vesicles" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 41: Macrophages - Immune response" Nucleoplasm "Golgi apparatus, Vesicles" "HPA006960: AB_1079254" "unprognostic (2.26e-1)" "unprognostic (4.96e-2)" "unprognostic (2.32e-3)" "unprognostic (1.03e-1)" "prognostic unfavorable (2.02e-4)" "unprognostic (4.07e-2)" "unprognostic (8.75e-3)" "unprognostic (3.60e-1)" "unprognostic (6.15e-3)" "unprognostic (1.04e-1)" "unprognostic (4.61e-2)" "unprognostic (5.01e-1)" "unprognostic (1.85e-2)" "unprognostic (9.49e-2)" "prognostic unfavorable (6.25e-4)" "unprognostic (3.57e-2)" "unprognostic (1.60e-1)" 139.3 43.7 53.5 165.8 81.9 207.0 95.5 79.6 70.0 121.2 70.5 121.1 46.3 100.5 77.8 62.7 108.2 114.1 63.9 52.2 63.0 182.3 107.7 192.1 112.3 94.0 79.4 67.6 64.6 56.5 39.0 71.3 92.7 105.9 116.1 63.9 116.4 83.4 36.3 71.6 57.9 93.5 77.3 119.6 70.7 10.6 77.6 68.6 116.8 37.6 123.7 214.1 83.1 109.4 79.2 157.8 89.4 43.8 13.9 11.0 90.7 100.2 309.0 93.6 139.1 62.6 206.3 39.9 126.8 86.1 108.7 95.5 40.1 186.4 88.4 304.2 45.8 2.8 117.1 310.3 212.9 12.5 12.9 35.0 320.8 79.6 210.7 84.4 0.3 2.7 25.3 149.5 1.5 75.8 1.8 183.3 146.4 104.0 0.6 12.1 19.6 228.2 79.0 110.4 22.2 68.0 172.9 219.4 183.9 136.3 122.5 66.7 0.8 38.7 65.3 23.0 24.2 59.2 140.6 100.5 45.1 95.8 225.5 508.8 149.5 284.0 459.6 130.2 277.2 174.0 284.0 412.7 178.0 173.9 318.9 381.4 2578.1 274.5 81.9 220.1 350.3 584.9 53.5 81.9 79.6 70.0 52.2 63.0 94.0 79.4 92.7 77.3 77.6 109.4 297.5 44.8 70.0 7.5 176.7 157.4 336.2 365.4 68.3 2.2 180.5 157.6 48.8 148.7 222.2 163.7 0.0 56.4 505.5 305.4 485.2 245.8 2.3 112.2 151.9 76.3 17.5 18.3 1.1 72.9 471.9 156.7 39.8 108.1 214.9 1.1 94.2 52.9 227.8 0.0 1.6 153.1 175.0 156.9 701.0 11.3 56.2 422.0 156.5 7.5 391.8 232.7 433.5 11.6 59.5 123.3 236.1 68.4 186.3 239.8 23.3 104.3 150.3 5.4 52.6 89.6 176.1 0.2 5.4 37.1 132.1 37.1 278.7 16.6 88.9 368.6 LMNA "CMD1A, HGPS, LGMD1B, LMN1, LMNL1, MADA, PRO1" ENSG00000160789 "Lamin A/C" P02545 1 156082573-156140081 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cancer-related genes, Cardiomyopathy, Charcot-Marie-Tooth disease, Congenital muscular dystrophy, Disease variant, Emery-Dreifuss muscular dystrophy, Limb-girdle muscular dystrophy, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Langerhans cells: 1533.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "myeloid DC: 85.1;T-reg: 83.2" "Group enriched" "Detected in all" 8 "dendritic cells: 85.1;granulocytes: 23.9;T-cells: 83.2" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004022, HPA006523, HPA006660" Supported Supported "Nuclear speckles" NA NA 5700000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 17: WM-115 - Nervous system development" "Cluster 24: Non-specific - Transcription regulation" "Nuclear speckles" "CAB004022: AB_2136278, HPA006523: , HPA006660: AB_1079231" "unprognostic (2.22e-2)" "unprognostic (1.89e-1)" "unprognostic (1.04e-2)" "unprognostic (5.75e-2)" "unprognostic (7.43e-3)" "unprognostic (1.47e-1)" "unprognostic (5.23e-3)" "unprognostic (3.27e-2)" "unprognostic (8.33e-2)" "unprognostic (5.90e-2)" "unprognostic (5.10e-2)" "unprognostic (6.34e-2)" "unprognostic (1.41e-2)" "unprognostic (1.24e-1)" "unprognostic (2.89e-1)" "unprognostic (3.08e-2)" "unprognostic (1.44e-2)" 280.2 174.8 17.6 64.9 27.1 58.1 231.5 24.1 20.6 221.7 33.0 183.3 72.8 271.4 14.5 256.2 173.8 92.1 221.7 15.8 23.1 120.9 93.2 188.5 18.2 30.3 25.2 178.2 81.8 21.3 76.9 53.0 26.1 125.3 38.2 4.7 176.1 42.8 190.0 364.3 136.8 78.8 21.0 84.1 160.6 61.9 30.9 15.3 147.4 23.8 22.9 168.7 217.6 41.8 518.8 269.7 26.2 72.4 119.5 238.7 169.4 607.3 379.6 221.3 146.8 68.3 311.9 2.8 338.7 417.9 94.6 515.4 31.4 227.8 70.3 188.6 50.8 175.4 168.4 130.8 124.0 25.7 412.9 133.0 92.0 154.8 134.7 120.2 207.5 0.7 82.8 21.9 205.8 193.1 1.0 67.8 32.1 202.9 706.0 1.6 195.9 137.7 128.9 105.6 33.8 114.9 414.3 154.2 427.4 56.2 230.1 74.2 727.9 241.6 233.0 389.1 393.3 39.5 10.5 4.9 449.2 24.8 760.4 23.9 8.3 0.4 2.8 2.1 2.5 2.4 17.8 7.3 85.1 0.2 0.2 0.7 2.1 3.7 0.2 0.3 83.2 14.6 17.6 27.1 24.1 20.6 15.8 23.1 30.3 25.2 26.1 21.0 30.9 41.8 353.5 262.8 350.0 16.0 179.1 610.5 1235.3 446.2 531.6 7.2 542.5 374.9 94.1 191.6 320.3 161.8 47.9 478.8 239.8 614.1 109.5 429.3 38.6 215.4 209.4 386.0 431.5 70.4 9.9 360.2 387.8 622.1 505.1 270.5 1181.8 145.5 277.7 103.1 343.0 13.5 15.1 601.2 177.0 60.6 1533.4 45.4 288.6 409.0 859.2 10.3 20.4 37.2 3.1 17.1 20.1 513.0 384.1 287.3 331.3 340.6 262.6 125.0 170.5 17.8 203.8 1028.4 766.8 107.4 42.2 404.1 602.4 680.9 472.3 111.6 513.8 942.6 LMNB2 LMN2 ENSG00000176619 "Lamin B2" Q03252 19 2427638-2456959 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Disease variant, Epilepsy, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Early spermatids: 220.2;Extravillous trophoblasts: 81.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022593, HPA047863, HPA062477" Enhanced Supported "Nuclear membrane" NA NA 110000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 29: Early spermatids - Spermatogenesis" "Nuclear membrane" "CAB022593: , HPA047863: AB_2680189, HPA062477: AB_2684776" "unprognostic (3.92e-2)" "unprognostic (1.61e-1)" "unprognostic (4.76e-2)" "unprognostic (4.05e-2)" "unprognostic (9.65e-2)" "unprognostic (1.17e-1)" "prognostic unfavorable (1.32e-4)" "unprognostic (2.53e-3)" "prognostic unfavorable (5.88e-4)" "unprognostic (1.96e-1)" "unprognostic (3.09e-3)" "prognostic unfavorable (9.53e-5)" "prognostic unfavorable (9.34e-5)" "prognostic favorable (3.98e-4)" "unprognostic (4.03e-1)" "unprognostic (1.37e-1)" "unprognostic (1.53e-2)" 9.7 10.1 8.9 15.3 8.6 17.3 7.7 11.5 9.8 11.9 6.4 13.1 10.9 11.9 2.4 32.1 10.7 3.4 10.6 8.5 10.1 9.5 6.0 11.2 12.8 8.7 9.0 13.4 8.1 3.6 12.3 14.6 8.4 9.8 6.2 3.5 9.1 4.9 14.9 10.6 12.2 5.5 8.0 12.3 10.4 10.9 10.5 23.1 8.7 5.2 10.5 10.0 12.4 8.0 181.5 114.0 80.8 105.7 17.3 27.2 107.5 119.2 57.7 117.7 88.8 152.0 75.6 83.5 47.8 55.9 68.1 185.6 72.4 84.8 60.0 102.4 86.3 66.4 40.3 119.8 20.9 93.5 64.6 24.5 21.4 63.4 49.7 22.0 60.9 76.2 117.8 51.9 56.4 105.4 107.9 51.8 154.0 97.8 98.6 150.1 102.4 70.0 33.7 89.8 118.7 68.8 99.6 65.6 39.6 44.7 65.9 95.7 85.1 112.5 116.6 174.8 180.6 45.6 41.8 83.5 91.3 88.5 148.3 0.0 0.6 0.8 1.0 0.6 1.6 0.4 1.1 1.0 0.8 0.9 1.1 1.3 0.0 0.9 2.1 3.5 0.4 0.6 8.9 8.6 11.5 9.8 8.5 10.1 8.7 9.0 8.4 8.0 10.5 8.0 8.6 3.2 4.2 2.6 9.4 20.6 14.8 7.9 10.2 8.2 8.8 8.1 5.7 2.8 5.3 5.5 8.4 30.4 9.7 17.5 9.8 7.0 220.2 7.7 14.9 12.7 6.0 19.6 3.0 11.8 81.6 14.3 14.3 11.7 4.5 31.4 8.2 2.7 21.2 13.5 3.9 15.1 6.1 6.8 18.2 31.4 9.3 10.3 1.8 3.7 12.2 9.4 11.3 2.0 3.3 12.7 9.1 7.9 25.5 24.4 12.7 4.9 5.7 10.8 13.1 14.3 11.2 8.6 15.0 30.0 20.0 13.8 11.4 12.0 23.1 19.2 LMX1A "LMX1, LMX1.1" ENSG00000162761 "LIM homeobox transcription factor 1 alpha" Q8TE12 1 165201867-165356715 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Developmental protein, DNA-binding" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "choroid plexus: 20.4" "Group enriched" "Detected in some" 16 "Early spermatids: 30.6;Enteroendocrine cells: 41.9;Late spermatids: 23.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Low region specificity" "Detected in single" "HPA028051, HPA030088" Approved "Nucleoplasm,Golgi apparatus,Vesicles" NA NA "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 17: Intestinal endocrine cells - Hormone signaling" "Nucleoplasm, Golgi apparatus, Vesicles" "HPA028051: AB_10599731, HPA030088: AB_10601106" "unprognostic (1.73e-1)" "unprognostic (9.57e-2)" "unprognostic (7.58e-2)" "unprognostic (1.59e-1)" "unprognostic (2.17e-1)" "unprognostic (2.82e-1)" "unprognostic (2.63e-1)" "unprognostic (3.22e-2)" "unprognostic (2.10e-3)" "unprognostic (1.51e-1)" "unprognostic (9.82e-3)" 0.7 0.0 0.0 0.0 0.0 0.0 0.3 0.7 0.1 0.3 20.4 0.3 1.0 0.0 0.0 0.1 0.1 0.0 0.1 0.7 1.3 0.0 0.0 0.0 0.0 0.2 2.1 0.0 0.0 0.0 3.1 0.0 0.5 0.0 0.5 0.0 0.0 0.0 0.4 0.1 0.6 0.0 0.0 0.0 0.0 1.3 2.5 0.0 0.1 1.0 0.0 0.2 0.1 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.1 0.7 1.3 0.2 2.1 0.5 0.0 2.5 1.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 30.6 0.2 0.0 0.1 41.9 0.0 0.1 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.9 0.0 0.0 0.0 23.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.6 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 LOXHD1 "DFNB77, FLJ32670, LH2D1" ENSG00000167210 "Lipoxygenase homology domains 1" Q8IVV2 18 46476972-46657220 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Hearing "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "epididymis: 7.2;kidney: 6.9;testis: 23.0" "Group enriched" "Detected in some" 70 "Early spermatids: 199.3;Late spermatids: 439.4" "Cancer enhanced" "Detected in single" "testis cancer: 0.5" "Region enhanced" "Detected in some" "basal ganglia: 3.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA077128 Approved "Plasma membrane" NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 25: Spermatids - Spermatogenesis" "Plasma membrane" "HPA077128: " "unprognostic (6.95e-2)" "unprognostic (1.88e-2)" "unprognostic (4.81e-3)" "unprognostic (2.65e-1)" "unprognostic (1.30e-2)" "unprognostic (7.75e-4)" "unprognostic (9.53e-2)" "unprognostic (7.91e-2)" "unprognostic (7.61e-2)" "unprognostic (9.44e-2)" "unprognostic (1.26e-2)" "unprognostic (1.93e-2)" "unprognostic (7.43e-3)" "unprognostic (6.48e-5)" "unprognostic (2.30e-1)" "unprognostic (8.10e-3)" "unprognostic (1.66e-3)" 2.3 0.0 0.5 0.0 3.4 2.8 0.6 0.0 2.1 0.0 0.1 0.1 0.0 0.1 7.2 0.0 1.7 0.2 0.9 0.3 0.0 6.9 0.0 1.0 0.0 0.0 0.1 0.1 0.2 0.2 1.9 0.7 0.0 0.0 0.0 0.0 0.0 0.2 0.7 0.2 0.1 0.0 0.0 0.8 0.1 23.0 0.3 0.1 0.2 0.2 0.0 0.2 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.5 3.4 0.0 2.1 0.3 0.0 0.0 0.1 0.0 0.0 0.3 0.9 1.2 3.2 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 199.3 0.0 0.1 0.9 0.0 0.0 4.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 3.6 0.0 0.0 0.0 0.0 439.4 1.8 0.3 0.0 0.0 0.3 0.0 0.0 1.5 0.6 0.0 0.0 2.2 0.0 0.0 0.0 0.1 1.5 0.0 0.0 0.0 0.1 4.5 1.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 LRAT LCA14 ENSG00000121207 "Lecithin retinol acyltransferase" O95237 4 154626945-154753120 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Sensory transduction, Vision" "Acyltransferase, Transferase" "Disease variant, Leber congenital amaurosis" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 2.6" "Cell type enriched" "Detected in many" 6 "Granulosa cells: 104.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "classical monocyte: 1.9" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in some" 11 "NTERA-2: 15.3" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA070726 Uncertain "Endoplasmic reticulum,Golgi apparatus" NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 45: Intestine - Brush border" "Cluster 5: NTERA-2 - Transcription" "Cluster 40: Granulosa cells - Unknown function" "Golgi apparatus" "Endoplasmic reticulum" "HPA070726: " "unprognostic (3.64e-3)" "unprognostic (1.07e-2)" "unprognostic (1.05e-1)" "unprognostic (1.34e-1)" "unprognostic (4.75e-2)" "unprognostic (2.01e-1)" "unprognostic (3.38e-1)" "unprognostic (9.15e-2)" "unprognostic (2.48e-1)" "unprognostic (2.24e-1)" "unprognostic (2.65e-1)" "unprognostic (9.25e-2)" "unprognostic (1.03e-4)" "unprognostic (4.49e-6)" "unprognostic (6.11e-2)" "unprognostic (1.05e-1)" "unprognostic (3.98e-1)" 0.2 0.2 0.6 0.2 0.7 0.5 0.4 0.7 2.6 0.2 1.6 0.5 1.2 0.1 0.3 0.0 0.2 0.5 0.1 0.7 1.2 0.1 2.1 0.3 0.1 1.0 1.1 0.3 0.8 0.2 0.2 0.1 1.3 0.4 0.1 1.0 0.1 0.5 0.8 0.4 1.6 0.1 0.7 0.1 0.3 0.8 0.7 0.0 1.5 0.0 0.1 0.1 0.1 0.9 0.5 0.4 0.2 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.1 0.3 0.2 0.2 0.0 0.1 0.2 0.0 0.0 0.1 0.1 0.1 0.1 0.0 0.3 15.3 0.0 0.0 0.0 0.0 0.1 1.4 0.4 0.0 0.0 0.1 0.0 0.1 0.2 0.1 0.0 0.0 0.3 0.1 0.4 0.1 0.0 0.0 0.0 0.0 0.1 0.4 0.6 1.9 0.1 0.1 0.6 0.1 0.1 0.1 0.1 1.5 0.2 0.1 0.1 0.8 0.2 0.2 0.2 0.1 2.2 0.6 0.7 0.7 2.6 0.7 1.2 1.0 1.1 1.3 0.7 0.7 0.9 0.2 0.0 4.4 4.6 0.1 1.1 4.4 4.0 0.6 0.5 8.6 9.1 0.3 11.5 1.7 0.0 0.0 0.1 0.3 0.8 3.9 1.2 15.2 0.9 0.5 0.3 0.0 0.0 2.2 0.8 0.1 1.5 2.0 2.2 0.0 104.4 1.4 2.2 0.1 0.0 0.6 0.9 2.0 0.8 2.8 3.2 0.0 0.3 5.4 0.0 0.0 3.9 0.0 1.0 2.2 1.2 0.0 0.0 0.0 2.4 12.3 1.0 0.9 0.8 0.0 1.4 8.1 10.5 4.7 1.4 1.1 0.3 0.6 0.0 1.2 0.6 LRIT3 "CSNB1F, FIGLER4, FLJ44691" ENSG00000183423 "Leucine rich repeat, Ig-like and transmembrane domains 3" Q3SXY7 4 109848107-109872315 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Sensory transduction, Vision" "Congenital stationary night blindness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 22 "retina: 17.6" "Group enriched" "Detected in some" 6 "Cone photoreceptor cells: 33.3;Muller glia cells: 10.2;Rod photoreceptor cells: 9.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA013454 Enhanced Approved Nucleoplasm,Mitochondria,Cytosol NA NA "Cluster 77: Retina - Visual perception" "Cluster 9: Photoreceptor cells - Phototransduction" "Nucleoplasm, Mitochondria, Cytosol" "HPA013454: AB_1853277" "unprognostic (5.41e-2)" "unprognostic (6.82e-2)" "unprognostic (4.20e-2)" "unprognostic (6.50e-2)" "unprognostic (3.42e-1)" "unprognostic (7.67e-3)" "unprognostic (1.54e-1)" "unprognostic (5.25e-2)" "unprognostic (3.16e-2)" "unprognostic (4.49e-2)" "unprognostic (6.92e-3)" "unprognostic (3.34e-3)" "unprognostic (2.14e-1)" "unprognostic (4.01e-2)" "unprognostic (1.69e-1)" "unprognostic (1.35e-1)" "unprognostic (1.14e-2)" 0.2 0.2 0.4 0.0 0.5 0.1 0.3 0.3 0.6 0.4 0.2 0.2 0.0 0.2 0.3 0.2 0.3 0.0 0.1 0.4 0.2 0.7 0.3 0.2 0.1 0.3 0.3 0.2 0.3 0.0 0.2 0.0 0.4 0.3 0.0 17.6 0.2 0.1 0.3 0.6 0.2 0.0 0.2 0.3 0.2 0.5 0.3 0.1 0.3 0.0 0.0 0.3 0.2 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.5 0.3 0.6 0.4 0.2 0.3 0.3 0.4 0.2 0.3 0.5 0.0 0.0 0.0 2.3 0.1 0.0 0.0 0.0 0.0 1.2 0.2 0.1 0.1 0.0 0.0 0.0 33.3 0.0 0.0 0.0 1.9 0.0 0.2 0.1 0.0 0.0 0.0 0.0 2.7 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 2.6 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.0 0.0 10.2 0.0 0.5 1.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 9.6 0.0 0.0 0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 LRP4 "CLSS, LRP-4, MEGF7, SOST2" ENSG00000134569 "LDL receptor related protein 4" O75096 11 46856717-46918642 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Differentiation, Endocytosis, Wnt signaling pathway" "Developmental protein, Receptor" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 46.7;skin 1: 31.6" "Cell type enhanced" "Detected in many" "Astrocytes: 123.1;Cone photoreceptor cells: 41.7;Distal enterocytes: 31.1;Oligodendrocyte precursor cells: 137.2;Oligodendrocytes: 31.3" "Group enriched" "Detected in all" 4 "colorectal cancer: 12.2;endometrial cancer: 8.6;glioma: 13.2;testis cancer: 15.6;thyroid cancer: 28.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 21.3;SuSa: 16.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA011934, HPA012300" Approved Uncertain Nucleoplasm,Nucleoli,Mitochondria NA NA "Cluster 27: Brain & Skin - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 68: Oligodendrocytes - Mixed function" "Nucleoplasm, Nucleoli, Mitochondria" "HPA011934: AB_1853286, HPA012300: AB_1853288" "unprognostic (1.46e-1)" "unprognostic (4.07e-2)" "unprognostic (2.86e-1)" "unprognostic (1.33e-2)" "unprognostic (4.39e-2)" "unprognostic (9.73e-3)" "unprognostic (5.29e-4)" "unprognostic (8.61e-2)" "unprognostic (2.29e-2)" "unprognostic (2.77e-1)" "unprognostic (1.92e-1)" "unprognostic (1.33e-1)" "unprognostic (7.59e-2)" "unprognostic (7.95e-2)" "unprognostic (2.76e-2)" "unprognostic (9.90e-3)" "unprognostic (6.79e-2)" 0.7 1.4 23.3 0.9 30.5 0.0 1.5 19.1 21.3 2.3 0.0 4.8 3.4 1.6 0.9 1.8 1.4 2.0 6.9 24.2 16.0 0.7 0.2 2.9 0.1 46.7 23.0 4.6 2.2 5.6 2.6 2.6 19.8 2.1 3.4 7.9 1.7 2.3 4.4 31.6 4.9 1.5 21.3 3.9 7.8 1.1 30.9 1.5 2.4 7.7 0.3 0.9 1.4 25.6 0.1 9.6 21.3 6.5 13.4 3.7 4.9 1.0 1.9 2.8 3.2 2.8 0.0 0.0 1.4 11.4 3.1 3.9 12.0 7.5 2.2 0.0 10.3 1.0 3.8 6.8 2.8 0.1 1.9 4.5 4.2 4.4 1.1 2.5 2.5 2.6 0.9 0.0 1.6 0.8 0.2 0.3 11.9 0.0 0.9 1.6 7.3 0.0 0.3 2.8 0.1 14.2 1.2 0.0 3.4 16.2 0.3 0.5 0.2 5.7 3.5 6.5 2.1 0.0 0.0 0.4 4.3 0.7 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 23.3 30.5 19.1 21.3 24.2 16.0 46.7 23.0 19.8 21.3 30.9 25.6 0.2 0.0 1.9 123.1 0.0 8.2 2.7 2.4 10.8 0.5 0.3 1.9 6.2 0.0 1.9 1.8 41.7 2.6 0.0 31.1 1.9 0.0 0.5 1.0 4.7 1.0 0.0 0.0 19.7 0.4 0.4 5.0 3.1 4.4 5.1 1.6 1.8 0.4 0.2 0.0 18.6 2.8 0.0 0.0 0.4 0.0 1.8 0.2 1.8 15.0 0.6 9.3 0.0 137.2 31.3 0.3 3.0 1.2 0.0 1.0 8.0 0.3 1.1 2.7 0.0 12.4 0.9 0.2 0.8 2.3 10.9 1.4 0.2 8.4 3.3 0.8 LRP5 "BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPS, OPTA1, VBCH2" ENSG00000162337 "LDL receptor related protein 5" O75197 11 68312591-68449275 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Endocytosis, Wnt signaling pathway" "Developmental protein, Receptor" "Disease variant, Osteogenesis imperfecta, Osteopetrosis" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 129.7" "Cell type enhanced" "Detected in many" "Granulosa cells: 84.7;Proximal enterocytes: 54.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "OE19: 161.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013001, HPA030505" Approved NA NA 1500000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 85: Liver - Metabolism" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 40: Granulosa cells - Unknown function" "CAB013001: AB_2533267, HPA030505: AB_2673505" "unprognostic (3.67e-1)" "unprognostic (2.98e-2)" "unprognostic (1.11e-1)" "unprognostic (3.13e-2)" "unprognostic (3.33e-1)" "unprognostic (1.97e-2)" "unprognostic (1.05e-1)" "unprognostic (2.94e-2)" "unprognostic (9.63e-2)" "unprognostic (2.54e-1)" "unprognostic (2.78e-1)" "unprognostic (6.82e-2)" "prognostic favorable (3.55e-10)" "unprognostic (2.28e-2)" "unprognostic (1.62e-2)" "unprognostic (1.58e-1)" "unprognostic (7.42e-2)" 35.6 37.6 9.6 6.9 11.4 3.2 36.9 10.9 11.2 26.0 44.4 32.4 43.1 30.6 4.1 18.5 26.4 21.0 35.7 8.6 9.2 30.3 129.7 23.3 4.3 12.6 11.9 27.9 34.9 11.6 15.9 23.2 11.7 25.1 11.2 1.7 73.3 20.0 10.4 19.3 44.8 11.1 10.1 8.9 31.8 5.6 10.2 9.6 33.4 7.3 2.6 24.5 19.4 10.6 30.9 103.6 11.0 25.4 20.6 11.4 47.0 14.0 12.1 8.3 7.5 58.7 104.2 0.0 87.5 18.2 35.1 38.9 9.9 37.3 1.2 5.0 22.6 21.6 52.8 77.2 20.8 15.8 2.0 16.4 12.5 0.4 13.6 22.3 23.7 18.8 38.5 1.6 6.0 69.5 23.7 62.7 19.6 161.2 41.7 29.6 30.1 49.7 14.2 82.1 10.6 21.6 37.0 49.4 41.0 5.3 34.6 36.2 31.5 0.2 9.0 11.6 15.8 6.3 0.8 6.3 0.0 9.7 11.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.0 0.0 9.6 11.4 10.9 11.2 8.6 9.2 12.6 11.9 11.7 10.1 10.2 10.6 37.4 6.4 5.4 17.0 1.1 9.2 8.5 11.3 10.8 0.2 24.4 23.2 5.6 21.5 9.6 7.3 0.0 49.0 0.0 42.7 0.0 11.7 1.1 19.2 6.5 20.4 17.5 10.7 1.1 9.8 6.7 10.6 30.5 12.5 1.3 84.7 31.8 52.5 8.4 0.0 5.7 43.0 18.3 3.2 4.6 1.0 3.1 1.7 1.8 11.2 1.3 8.8 0.0 13.0 5.2 12.5 32.4 9.8 5.7 13.0 54.9 8.5 4.8 0.1 6.6 18.5 10.9 0.8 7.3 7.6 5.3 24.8 1.0 1.3 25.1 13.8 LRPAP1 "A2MRAP, HBP44, RAP" ENSG00000163956 "LDL receptor related protein associated protein 1" P30533 4 3503612-3532446 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Heparin-binding "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 584.3;Syncytiotrophoblasts: 693.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008001, CAB025518" Enhanced Supported Supported "Endoplasmic reticulum" NA NA 810000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 35: Non-specific - Unknown function" "Cluster 39: CACO-2 - Unknown function" "Cluster 47: Cytotrophoblasts - Unknown function" "Endoplasmic reticulum" "CAB025518: , HPA008001: AB_1853292" "unprognostic (3.20e-3)" "unprognostic (7.01e-2)" "unprognostic (2.30e-1)" "unprognostic (2.22e-2)" "unprognostic (1.37e-2)" "unprognostic (9.61e-2)" "unprognostic (1.01e-2)" "unprognostic (3.89e-3)" "unprognostic (8.58e-2)" "unprognostic (6.12e-2)" "unprognostic (2.14e-3)" "unprognostic (2.19e-1)" "prognostic favorable (4.67e-11)" "unprognostic (6.25e-2)" "unprognostic (1.56e-1)" "unprognostic (2.58e-1)" "unprognostic (5.61e-2)" 6.6 9.0 6.6 2.6 10.3 6.0 6.4 8.6 7.6 8.9 10.7 7.6 3.3 8.6 3.2 5.8 7.5 1.9 19.3 5.8 8.1 12.7 9.6 8.5 2.1 8.0 6.9 9.5 14.4 7.7 14.4 6.3 7.9 8.2 1.7 2.8 10.1 4.1 8.9 6.3 6.7 1.9 5.2 8.6 9.2 9.2 7.5 1.6 8.9 2.4 1.4 7.3 6.3 6.3 3.7 7.4 5.7 8.2 5.5 2.9 12.5 5.9 4.8 4.3 3.1 14.9 7.0 2.1 6.0 4.2 7.0 6.2 3.4 5.8 2.4 1.6 7.9 2.9 7.8 10.4 4.2 4.7 12.5 4.0 4.3 3.9 1.9 4.7 5.2 3.9 5.1 7.0 3.6 5.9 3.1 18.4 4.9 5.1 7.8 4.3 4.2 7.1 4.8 8.6 5.6 4.6 7.4 3.0 8.1 3.4 6.7 8.6 5.6 5.1 4.7 4.1 8.2 4.2 2.9 2.8 5.9 13.3 7.2 21.9 23.2 60.1 9.3 19.7 8.1 9.9 8.6 8.8 13.3 10.0 9.4 8.6 20.5 11.7 19.1 10.2 11.5 27.3 6.6 10.3 8.6 7.6 5.8 8.1 8.0 6.9 7.9 5.2 7.5 6.3 95.0 109.0 90.9 21.2 78.0 67.8 174.6 267.7 52.9 70.6 75.3 84.2 165.9 108.7 158.7 195.0 45.9 584.3 75.8 147.7 50.9 159.3 40.4 85.5 229.6 88.2 82.6 35.7 22.5 107.9 184.0 152.5 79.0 71.2 81.1 102.3 62.4 92.6 243.1 38.7 20.6 121.6 164.8 100.5 80.2 60.0 126.2 154.2 147.7 16.9 107.1 140.0 91.6 28.1 16.7 95.4 153.4 151.6 205.2 124.5 204.6 273.7 144.8 86.2 78.9 82.8 108.1 272.5 161.4 40.7 61.4 693.5 86.0 99.9 109.9 140.5 LRRK2 "DKFZp434H2111, FLJ45829, PARK8, RIPK7, ROCO2" ENSG00000188906 "Leucine rich repeat kinase 2" Q5S007 12 40196744-40369285 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, Differentiation" "GTPase activation, Hydrolase, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "lung: 52.4" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 502.2;Excitatory neurons: 92.0;monocytes: 133.1;Oligodendrocyte precursor cells: 256.9" "Cancer enhanced" "Detected in many" "renal cancer: 17.1;thyroid cancer: 22.7" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in many" 8 "neutrophil: 58.2" "Lineage enriched" "Detected in many" 8 "granulocytes: 58.2" "Cell line enhanced" "Detected in some" "A549: 4.6;ASC TERT1: 5.6;BJ hTERT+: 3.2;RPTEC TERT1: 7.8;T-47d: 3.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014293, CAB037160" Approved Supported Vesicles NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 11: Alveolar cells - Smell perception" Vesicles "CAB037160: AB_1840989, HPA014293: AB_1853353" "unprognostic (2.67e-1)" "unprognostic (1.75e-1)" "unprognostic (6.45e-3)" "unprognostic (1.06e-1)" "unprognostic (3.00e-2)" "unprognostic (6.10e-3)" "unprognostic (2.71e-1)" "unprognostic (3.14e-1)" "unprognostic (2.25e-1)" "unprognostic (9.07e-2)" "unprognostic (2.76e-1)" "unprognostic (1.23e-1)" "prognostic favorable (3.02e-6)" "unprognostic (2.55e-2)" "unprognostic (3.43e-2)" "unprognostic (2.01e-3)" "unprognostic (5.21e-3)" 4.8 3.1 1.1 10.1 1.9 9.0 2.6 0.9 2.1 5.1 1.2 4.3 0.6 4.8 1.9 7.0 4.1 6.2 3.9 1.3 1.1 10.9 5.6 52.4 6.8 1.7 1.1 5.4 3.6 8.4 2.1 1.2 1.4 2.6 1.8 1.5 3.5 2.0 5.5 2.1 3.6 4.0 1.1 10.8 2.1 0.8 1.2 2.5 2.9 7.9 5.4 4.5 5.5 1.9 0.0 4.6 0.0 0.0 2.3 5.6 0.0 1.3 3.2 0.1 0.1 0.0 0.0 0.0 0.0 0.8 0.1 0.0 0.0 0.0 0.2 0.0 0.3 0.2 0.1 0.0 0.6 0.4 0.0 2.1 0.4 0.0 0.0 2.5 0.4 0.0 0.0 0.0 0.4 0.0 0.0 0.8 0.1 0.0 0.0 0.0 0.0 0.0 7.8 0.0 0.0 0.3 0.0 0.5 2.7 0.1 3.1 1.5 1.0 0.4 0.5 0.6 0.4 0.0 0.0 0.0 1.3 0.0 1.7 0.0 7.2 2.2 0.0 5.2 0.0 1.8 0.0 0.0 2.1 1.7 0.0 0.0 58.2 0.0 6.9 0.3 0.0 1.3 1.1 1.9 0.9 2.1 1.3 1.1 1.7 1.1 1.4 1.1 1.2 1.9 7.4 32.1 502.2 17.3 29.9 2.4 1.8 0.4 2.8 8.6 1.3 1.4 7.8 5.7 17.3 27.6 0.0 0.0 1.9 0.0 1.9 1.3 0.5 0.4 2.6 7.0 0.0 2.1 92.0 2.7 0.1 16.1 0.5 0.4 13.9 2.7 13.2 8.2 4.6 47.1 28.0 0.0 0.0 55.8 8.7 1.2 19.0 52.2 12.4 73.1 133.1 8.6 3.1 256.9 3.1 0.8 1.1 12.0 2.8 0.6 0.0 22.5 3.4 1.0 0.0 22.5 4.8 0.3 1.0 12.6 3.1 0.4 3.4 11.2 0.0 0.7 LRSAM1 "CMT2P, FLJ31641, RIFLE, TAL" ENSG00000148356 "Leucine rich repeat and sterile alpha motif containing 1" Q6UWE0 9 127451489-127503499 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, Protein transport, Transport, Ubl conjugation pathway" Transferase "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 32.0;Excitatory neurons: 28.6;Inhibitory neurons: 26.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021403, HPA021844, CAB037304" Supported Approved Cytosol NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 27: Brain & Skin - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "CAB037304: AB_2138198, HPA021403: AB_1853366, HPA021844: AB_1853368" "unprognostic (8.83e-2)" "unprognostic (3.13e-1)" "unprognostic (7.48e-3)" "unprognostic (4.15e-3)" "unprognostic (9.42e-2)" "unprognostic (2.05e-1)" "unprognostic (1.64e-1)" "unprognostic (5.00e-2)" "unprognostic (1.66e-1)" "unprognostic (2.72e-2)" "prognostic favorable (6.78e-6)" "unprognostic (1.27e-1)" "prognostic favorable (5.72e-4)" "unprognostic (1.94e-2)" "unprognostic (3.26e-1)" "unprognostic (9.07e-2)" "unprognostic (3.33e-2)" 7.2 9.8 8.6 3.4 8.6 2.0 7.3 7.3 12.5 10.7 5.2 16.5 3.4 9.0 5.9 8.7 7.8 3.9 17.3 8.8 8.8 9.0 8.8 7.4 4.5 11.1 7.6 10.7 5.7 6.9 9.0 3.4 11.4 9.1 2.6 2.3 7.5 5.6 13.5 21.2 9.1 5.0 7.0 9.5 9.5 4.3 7.9 3.4 8.8 7.2 3.2 12.3 10.2 9.0 5.7 10.8 4.8 10.7 9.8 9.1 8.3 5.3 8.1 10.0 7.6 8.9 5.9 9.8 5.9 9.9 3.6 18.7 7.8 13.3 3.8 11.5 5.3 5.2 9.0 10.2 9.4 6.2 7.3 6.1 7.9 6.1 12.2 10.7 11.2 7.6 4.8 7.6 4.5 17.6 3.9 4.5 4.7 17.4 9.3 7.1 5.6 18.4 11.5 5.1 9.8 9.2 4.1 12.6 8.8 4.3 26.5 3.2 10.2 4.6 5.6 4.2 2.5 6.2 7.9 1.1 9.1 4.5 2.6 18.5 4.8 21.3 3.7 6.5 4.7 3.7 2.8 3.5 6.1 2.7 1.1 1.4 4.0 1.3 6.8 3.6 2.3 3.8 8.6 8.6 7.3 12.5 8.8 8.8 11.1 7.6 11.4 7.0 7.9 9.0 5.3 9.6 3.9 32.0 5.1 1.1 3.1 2.9 4.6 6.7 5.2 5.0 20.4 4.3 7.3 0.0 6.2 5.0 5.3 6.0 5.9 7.1 0.6 3.6 4.7 4.8 1.2 2.5 28.6 1.4 2.1 4.9 12.2 4.6 9.5 6.6 3.3 7.1 6.3 11.8 26.9 5.8 14.2 5.6 3.7 1.2 2.8 7.4 3.6 10.3 7.4 4.7 3.1 18.1 21.0 4.7 5.0 5.3 3.9 5.0 6.6 5.8 6.0 5.2 0.0 5.1 6.0 5.7 3.6 5.8 2.7 7.0 5.6 3.9 4.8 3.3 LRTOMT "CFAP111, COMT2, DFNB63, LRRC51, LRTOMT1, LRTOMT2" ENSG00000184154 "Leucine rich transmembrane and O-methyltransferase domain containing" Q96E66 11 72080337-72096895 "Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "fallopian tube: 67.1;testis: 49.3" "Group enriched" "Detected in many" 12 "Early spermatids: 574.9;Late spermatids: 2222.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "T-47d: 39.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039949 Approved Uncertain Microtubules NA NA "Cluster 15: NK-cells - Transcription" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 6: T47d - Mammary gland" "Cluster 25: Spermatids - Spermatogenesis" Microtubules "HPA039949: AB_10960708" "unprognostic (2.68e-1)" "unprognostic (6.43e-2)" "unprognostic (1.85e-2)" "prognostic favorable (7.70e-4)" "unprognostic (8.09e-2)" "unprognostic (9.07e-2)" "unprognostic (1.42e-1)" "unprognostic (1.90e-1)" "unprognostic (4.22e-2)" "prognostic favorable (5.36e-4)" "unprognostic (6.12e-2)" "unprognostic (8.43e-2)" "unprognostic (2.64e-2)" "unprognostic (1.58e-1)" "unprognostic (1.34e-1)" "unprognostic (1.67e-1)" "unprognostic (1.44e-1)" 5.0 4.5 21.1 2.5 21.8 2.1 8.7 19.5 24.2 8.7 25.1 5.4 3.7 7.2 17.1 3.8 67.1 3.4 3.7 19.1 19.2 11.7 7.9 7.7 3.2 23.0 25.7 8.1 8.9 10.3 8.9 5.4 21.4 9.3 7.7 19.7 4.4 5.4 7.5 5.8 3.4 5.7 23.4 4.0 5.5 49.3 21.0 4.5 11.0 4.6 3.6 4.1 3.8 22.0 3.9 13.7 8.9 6.9 7.3 6.7 2.1 4.4 3.6 4.0 3.5 6.6 20.4 5.1 6.6 7.8 9.6 7.3 6.3 10.8 4.5 9.4 6.2 3.5 6.3 4.8 1.3 3.0 3.9 2.9 5.4 6.0 4.6 6.4 1.5 10.2 4.0 7.8 6.0 13.6 9.0 6.0 4.4 22.8 3.6 10.8 8.6 7.7 15.9 4.7 8.2 6.2 8.7 19.4 10.4 6.1 39.6 3.3 6.5 4.0 5.7 11.3 3.1 8.0 9.4 5.8 4.0 2.5 4.5 1.8 1.7 3.5 2.0 1.9 1.9 3.2 2.1 1.6 1.0 3.5 1.8 1.8 6.1 6.6 1.3 2.8 4.6 1.4 21.1 21.8 19.5 24.2 19.1 19.2 23.0 25.7 21.4 23.4 21.0 22.0 4.6 0.0 1.5 3.3 2.5 2.3 7.5 10.0 1.8 3.5 8.4 7.5 2.2 5.7 10.7 3.7 12.5 12.7 1.4 4.4 11.7 7.5 574.9 84.3 3.0 6.5 1.2 3.6 2.0 2.5 7.7 5.3 4.1 7.2 0.0 2.2 3.6 6.0 3.1 6.7 1.9 10.8 10.2 1.6 2.8 2222.2 14.9 3.3 1.8 1.9 1.4 21.3 4.1 2.0 3.6 2.0 2.5 10.1 5.1 6.8 4.0 19.9 113.1 16.6 6.6 6.1 7.9 90.3 28.1 2.2 2.4 13.1 1.7 2.9 3.4 6.5 LSS OSC ENSG00000160285 "Lanosterol synthase" P48449 21 46188141-46228824 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis" Isomerase "Cataract, Disease variant, Hypotrichosis, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hepatocytes: 132.0;Oligodendrocytes: 158.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "GAMG: 234.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA032060, HPA032062, CAB034116" Supported NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 15: Liver - Metabolism" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 15: Hepatocytes - Hemostasis" "CAB034116: AB_2138611, HPA032060: AB_10671085, HPA032062: AB_2674134" "unprognostic (2.78e-3)" "unprognostic (8.53e-3)" "unprognostic (6.95e-2)" "unprognostic (2.07e-1)" "unprognostic (1.74e-2)" "unprognostic (1.06e-1)" "unprognostic (2.74e-2)" "unprognostic (1.33e-2)" "unprognostic (1.72e-1)" "unprognostic (1.58e-2)" "unprognostic (1.68e-2)" "unprognostic (2.02e-2)" "unprognostic (2.34e-2)" "prognostic unfavorable (6.80e-4)" "unprognostic (1.92e-1)" "unprognostic (2.50e-1)" "prognostic unfavorable (3.07e-4)" 29.3 38.9 20.0 10.8 30.8 5.7 22.3 38.9 33.5 20.8 7.1 22.9 28.5 26.6 12.1 39.7 18.0 9.0 25.1 15.7 26.2 10.7 54.8 24.1 9.4 62.3 40.7 30.3 19.4 12.2 25.9 8.0 65.7 24.0 10.7 6.8 16.1 12.4 29.0 27.6 17.4 12.2 28.4 7.6 23.3 17.5 40.4 12.3 10.2 19.5 8.0 20.2 19.6 58.7 70.4 22.2 70.9 30.6 94.1 90.6 20.3 26.8 186.4 32.1 62.7 73.9 54.4 15.4 22.3 51.7 234.6 32.7 63.2 110.9 12.9 14.9 34.5 37.7 38.6 48.3 85.5 13.7 25.1 89.0 41.4 59.7 25.6 22.2 26.9 72.1 37.4 87.3 27.8 23.8 29.9 19.7 115.4 11.3 20.1 34.9 21.9 92.2 82.8 38.1 41.4 36.7 31.4 24.0 27.5 30.6 38.0 33.7 40.8 37.9 30.2 33.8 21.1 31.8 29.5 30.6 39.7 59.4 16.6 4.6 2.1 2.2 4.0 1.8 2.8 3.1 2.9 4.9 2.4 1.5 2.4 3.6 0.0 1.7 1.5 5.0 1.4 3.6 20.0 30.8 38.9 33.5 15.7 26.2 62.3 40.7 65.7 28.4 40.4 58.7 13.8 12.8 36.8 66.6 7.2 37.0 3.8 30.2 8.0 16.0 15.3 8.0 13.7 14.3 18.7 11.0 4.2 3.7 11.8 10.4 0.0 10.5 6.5 6.6 16.4 10.3 19.7 16.8 21.2 17.2 6.7 19.7 13.3 14.6 3.8 20.6 11.4 132.0 9.7 23.5 24.2 11.6 16.2 7.5 13.7 6.6 21.1 4.9 21.4 21.5 12.0 7.5 5.2 22.1 158.8 14.0 2.7 13.5 6.3 16.2 5.0 4.1 11.0 16.4 0.0 9.8 8.5 20.3 18.1 12.6 54.0 6.3 7.9 18.0 10.9 4.6 LYZ ENSG00000090382 Lysozyme P61626 12 69348381-69354234 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins" "Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase" "Amyloidosis, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 10588.1;salivary gland: 21115.5;stomach 1: 8941.1" "Cell type enhanced" "Detected in many" "Gastric mucus-secreting cells: 3106.1;Kupffer cells: 2841.2;Langerhans cells: 4859.1;Macrophages: 4870.7;monocytes: 7063.0;Pancreatic endocrine cells: 3152.5" "Cancer enhanced" "Detected in all" "stomach cancer: 976.9" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 4 "classical monocyte: 25266.2;myeloid DC: 14438.7" "Group enriched" "Detected in all" 20 "dendritic cells: 14438.7;monocytes: 25266.2" "Cell line enriched" "Detected in many" 13 "OE19: 12130.8" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB000055, HPA048284, HPA066182" Enhanced Approved "Nucleoplasm,Golgi apparatus,Actin filaments" "Secreted to blood" NA NA 1500000000 1500000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 21: OE19 - Mitochondria" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "Golgi apparatus, Actin filaments" Nucleoplasm "CAB000055: AB_2341230, HPA048284: AB_2680339, HPA066182: AB_2732741" "unprognostic (8.52e-2)" "unprognostic (6.12e-3)" "unprognostic (2.83e-1)" "unprognostic (7.29e-2)" "unprognostic (7.91e-2)" "prognostic favorable (7.45e-4)" "unprognostic (1.21e-1)" "unprognostic (7.40e-2)" "unprognostic (1.41e-1)" "unprognostic (2.08e-2)" "unprognostic (1.44e-1)" "unprognostic (3.13e-1)" "unprognostic (2.50e-1)" "unprognostic (2.37e-1)" "unprognostic (3.65e-2)" "unprognostic (5.78e-2)" "unprognostic (3.62e-2)" 95.8 27.8 3.5 802.1 4.0 10588.1 128.2 3.7 18.5 156.2 11.4 309.0 3605.0 65.7 4.2 106.3 33.9 1054.6 34.8 2.6 4.3 32.4 138.0 1355.2 739.7 8.0 7.3 20.4 63.1 13.8 7.2 91.3 12.2 40.2 273.8 4.4 21115.5 21.8 34.0 58.7 1322.2 123.9 5.4 621.0 8941.1 21.8 10.9 321.8 27.8 36.4 652.8 428.5 16.2 11.7 0.6 0.1 0.0 0.2 0.0 0.0 4.8 0.0 0.0 0.0 0.3 9.5 6.5 4.2 1.5 0.0 3.6 1.2 0.0 0.0 0.2 1.2 0.1 62.4 1.0 960.4 0.0 110.6 50.5 0.0 0.1 0.0 0.0 0.2 0.0 0.3 7.7 0.3 0.0 0.2 2.6 109.5 2.3 12130.8 0.2 1.6 1.4 16.7 0.3 0.5 0.8 3.6 0.5 0.1 0.5 0.7 0.0 489.0 0.6 0.0 2.6 2.3 0.9 2.6 1.1 1.2 0.1 518.5 0.0 443.4 25266.2 298.2 32.6 4798.4 52.3 100.5 20.1 22.7 14438.7 20.8 20.0 17.8 1007.7 108.1 880.1 301.2 31.1 25392.1 3.5 4.0 3.7 18.5 2.6 4.3 8.0 7.3 12.2 5.4 10.9 11.7 24.0 86.6 285.8 0.0 80.8 57.2 1.7 1.2 1.2 0.3 1205.7 32.3 0.2 734.9 51.1 27.6 0.0 5.6 39.6 32.1 0.0 55.1 1.9 2.6 1.9 25.1 12.5 264.6 0.2 547.3 9.4 26.8 3106.1 2.9 123.6 0.5 29.6 25.4 887.1 0.0 0.2 112.4 0.0 2841.2 4859.1 17.4 4.1 4870.7 53.4 0.0 7063.0 0.1 176.1 0.0 0.3 3152.5 600.5 2.2 9.0 2.7 41.8 6.6 33.8 1.0 39.5 7.4 9.9 0.7 3.9 1.5 38.2 8.5 50.6 0.3 111.4 38.3 MAF c-MAF ENSG00000178573 "MAF bZIP transcription factor" O75444 16 79585843-79600737 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding, Repressor" "Cancer-related genes, Cataract, Deafness, Disease variant, Dwarfism, Mental retardation, Proto-oncogene, Tumor suppressor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hepatic stellate cells: 407.6;Hofbauer cells: 273.6;Inhibitory neurons: 378.7;Kupffer cells: 394.7;Proximal enterocytes: 288.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 4 "basophil: 38.1" "Lineage enriched" "Detected in many" 4 "granulocytes: 38.1" "Group enriched" "Detected in some" 13 "Karpas-707: 207.0;RPMI-8226: 355.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010296, HPA028289" Approved NA NA "Cluster 38: Basophils - Unknown function" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 25: RPMI-8226 - Immune response" "Cluster 24: Non-specific - Transcription regulation" "CAB010296: AB_638562, HPA028289: AB_10602024" "unprognostic (6.76e-2)" "unprognostic (1.74e-2)" "unprognostic (6.45e-2)" "unprognostic (7.65e-2)" "unprognostic (7.89e-3)" "unprognostic (1.07e-2)" "unprognostic (1.63e-2)" "unprognostic (2.33e-1)" "unprognostic (8.76e-2)" "unprognostic (3.16e-2)" "unprognostic (9.46e-2)" "unprognostic (1.28e-1)" "prognostic unfavorable (3.74e-4)" "unprognostic (4.54e-2)" "unprognostic (7.83e-2)" "unprognostic (1.09e-2)" "unprognostic (4.56e-3)" 27.8 15.4 14.6 20.7 14.5 4.0 17.3 10.3 13.5 35.0 14.2 11.4 70.3 23.5 6.0 22.6 20.1 16.7 6.8 13.7 13.0 48.2 25.7 18.8 30.9 19.0 22.6 39.2 3.2 50.8 5.3 36.1 17.6 18.4 10.7 4.7 11.8 15.4 49.6 57.8 83.0 17.8 18.7 26.0 13.0 10.0 28.7 17.9 23.1 19.8 23.9 17.7 30.5 29.8 0.0 0.0 22.4 0.0 0.8 0.0 0.5 2.2 0.1 0.0 0.0 0.3 0.0 0.1 0.0 1.2 0.0 0.8 0.7 0.4 0.0 7.2 8.3 0.0 0.0 0.2 1.0 0.1 14.3 0.1 6.4 0.0 0.2 0.0 0.0 0.3 2.4 207.0 1.5 0.1 0.2 0.4 13.5 0.0 0.0 0.1 6.2 355.1 0.0 1.9 0.5 0.3 0.9 0.2 0.6 8.7 0.2 0.0 4.5 0.0 6.9 0.5 0.9 0.0 0.0 0.0 0.9 0.0 1.4 38.1 0.3 0.0 1.1 1.1 8.6 0.0 3.2 2.7 0.1 0.0 0.2 0.5 0.0 0.9 0.3 0.0 4.7 0.6 14.6 14.5 10.3 13.5 13.7 13.0 19.0 22.6 17.6 18.7 28.7 29.8 40.2 9.6 14.6 24.8 10.4 88.3 3.7 30.1 51.2 9.7 8.5 33.1 8.2 57.2 7.7 3.7 0.0 1.7 71.5 18.2 11.7 1.7 1.1 8.1 114.1 42.7 3.0 8.4 5.1 0.8 3.0 73.0 12.8 6.6 22.1 73.0 407.6 63.7 273.6 0.0 378.7 8.9 16.2 394.7 57.9 9.0 149.8 127.2 44.4 122.7 2.7 78.1 40.2 67.3 20.0 4.0 9.9 115.1 48.1 33.9 288.9 146.6 3.0 2.7 13.1 42.7 40.0 1.1 2.0 107.4 141.2 4.2 122.2 28.0 10.1 5.4 MAG "GMA, S-MAG, SIGLEC-4A, SIGLEC4A" ENSG00000105695 "Myelin associated glycoprotein" P20916 19 35292125-35313807 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 33 "brain: 731.4" "Cell type enriched" "Detected in some" 12 "Oligodendrocytes: 267.8" "Cancer enriched" "Detected in some" 7 "glioma: 20.3" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 12 "plasmacytoid DC: 2.9" "Lineage enriched" "Detected in single" 12 "dendritic cells: 2.9" "Cell line enriched" "Detected in some" 22 "WM-115: 36.6" "Region enhanced" "Detected in all" "white matter: 2742.2" "Low region specificity" "Detected in all" "CAB009345, HPA012499" Enhanced NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 17: WM-115 - Nervous system development" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "CAB009345: AB_670104, HPA012499: AB_1854238" "unprognostic (2.70e-3)" "unprognostic (2.70e-2)" "unprognostic (8.06e-3)" "unprognostic (1.23e-1)" "unprognostic (6.93e-2)" "unprognostic (3.74e-1)" "unprognostic (1.50e-1)" "unprognostic (2.39e-1)" "unprognostic (1.06e-1)" "unprognostic (2.00e-1)" "unprognostic (5.62e-2)" "unprognostic (5.18e-4)" "unprognostic (6.29e-2)" "unprognostic (2.19e-1)" "unprognostic (8.87e-2)" "unprognostic (1.66e-1)" 0.3 1.3 121.5 0.0 366.4 0.0 0.3 314.0 237.4 0.3 4.2 0.1 0.0 0.2 0.0 0.0 4.2 0.0 0.5 157.7 195.2 0.3 0.2 0.3 0.1 459.9 317.3 22.4 0.1 0.0 0.5 0.3 417.5 0.3 0.0 0.0 0.2 0.3 0.1 0.2 0.1 0.0 247.8 1.1 0.1 0.6 303.0 0.0 1.0 0.0 0.0 0.2 0.5 731.4 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.1 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.5 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.3 0.0 36.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 2.9 0.0 0.0 121.5 366.4 314.0 237.4 157.7 195.2 459.9 317.3 417.5 247.8 303.0 731.4 1.2 0.0 0.0 1.6 0.2 0.0 0.2 0.0 0.0 0.0 0.3 4.4 4.1 0.0 0.0 0.0 0.0 0.2 4.0 0.0 1.9 0.0 0.1 0.0 0.0 4.2 0.0 0.4 0.5 0.5 5.4 2.7 0.0 0.0 4.5 21.0 12.8 0.0 1.0 0.0 0.6 0.0 0.0 0.6 0.0 0.1 1.8 1.2 0.0 1.0 0.1 0.0 0.0 0.5 267.8 0.6 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.3 4.3 0.0 0.0 0.3 0.4 11.0 0.0 0.0 MAK "dJ417M14.2, RP62" ENSG00000111837 "Male germ cell associated kinase" P20794 6 10762723-10838553 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Differentiation, Spermatogenesis, Transcription, Transcription regulation" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 22 "retina: 118.9" "Group enriched" "Detected in many" 5 "Cone photoreceptor cells: 369.1;Early spermatids: 119.7;Rod photoreceptor cells: 330.1" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in single" "Immune cell enriched" "Detected in single" 9 "neutrophil: 6.3" "Lineage enriched" "Detected in single" 9 "granulocytes: 6.3" "Cell line enhanced" "Detected in single" "HDLM-2: 1.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 79: Retina - Phototransduction" "Cluster 44: HDLM-2 - Immune response" "Cluster 9: Photoreceptor cells - Phototransduction" "unprognostic (1.23e-3)" "unprognostic (8.77e-3)" "unprognostic (2.44e-1)" "unprognostic (3.81e-2)" "unprognostic (6.62e-2)" "unprognostic (1.35e-3)" "unprognostic (1.97e-2)" "unprognostic (2.53e-1)" "unprognostic (3.21e-2)" "unprognostic (2.42e-2)" "unprognostic (1.13e-3)" "unprognostic (6.73e-2)" "unprognostic (6.59e-5)" "unprognostic (1.55e-1)" "unprognostic (8.40e-2)" "unprognostic (7.71e-3)" "unprognostic (4.59e-2)" 0.3 0.1 0.2 0.6 0.0 0.6 0.4 1.5 0.4 0.3 5.4 0.0 0.1 0.4 0.0 0.2 5.4 0.4 0.1 0.1 0.0 0.2 0.0 0.7 0.1 0.7 0.9 0.1 0.2 4.6 0.8 0.1 0.1 0.2 0.0 118.9 0.2 0.0 0.1 0.3 0.1 0.0 0.2 0.7 0.3 4.7 0.2 0.0 0.2 0.0 0.1 0.1 0.1 0.4 0.7 0.0 0.3 0.2 0.0 0.0 0.4 0.0 0.0 0.2 0.3 0.0 0.4 0.1 0.1 0.0 0.4 0.1 0.1 0.0 0.1 1.3 0.4 0.0 0.0 0.0 0.0 0.5 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.1 0.4 0.2 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.5 0.2 0.0 0.1 0.0 0.2 0.2 0.1 0.0 0.1 0.2 0.0 0.2 0.2 0.0 0.1 0.0 0.1 0.1 0.4 0.6 0.3 0.3 0.3 0.3 0.1 0.3 0.2 0.3 0.4 0.3 0.5 6.3 0.2 0.6 0.3 0.1 0.1 0.2 0.0 1.5 0.4 0.1 0.0 0.7 0.9 0.1 0.2 0.2 0.4 2.1 0.0 6.4 16.3 1.5 0.4 2.3 0.8 2.8 14.6 4.0 3.9 0.9 0.0 5.3 3.7 369.1 0.5 0.5 0.1 0.0 0.4 119.7 43.3 1.7 1.8 0.0 1.3 45.6 0.2 1.0 2.2 1.1 3.8 2.5 0.3 1.1 0.1 0.2 5.0 39.4 0.0 2.0 0.6 0.7 47.1 0.6 1.3 1.8 12.2 1.3 23.6 0.0 30.7 21.5 0.1 0.0 0.4 1.0 1.1 0.0 0.1 48.9 330.1 0.0 5.4 1.5 15.2 5.5 0.7 0.4 0.8 0.8 0.3 0.0 0.8 MAPK10 "JNK3, p493F12, p54bSAPK, PRKM10" ENSG00000109339 "Mitogen-activated protein kinase 10" P53779 4 85990007-86594625 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Biological rhythms" "Kinase, Serine/threonine-protein kinase, Transferase" "Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 91.3" "Cell type enhanced" "Detected in many" "Astrocytes: 902.0;Excitatory neurons: 1018.9;Inhibitory neurons: 727.8;Late spermatids: 400.5;Oligodendrocyte precursor cells: 596.6;Oligodendrocytes: 302.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in many" 6 "AF22: 155.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB022625 Approved NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 10: Brain - Neuronal signaling" "Cluster 12: NES - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "CAB022625: " "unprognostic (2.46e-2)" "unprognostic (4.36e-2)" "unprognostic (1.13e-1)" "unprognostic (4.05e-2)" "unprognostic (5.17e-2)" "unprognostic (2.03e-1)" "unprognostic (4.59e-2)" "unprognostic (4.82e-2)" "unprognostic (3.81e-2)" "unprognostic (4.45e-2)" "unprognostic (1.18e-3)" "unprognostic (3.02e-2)" "prognostic favorable (3.11e-4)" "unprognostic (1.92e-2)" "unprognostic (1.44e-1)" "unprognostic (6.22e-3)" "prognostic favorable (5.57e-4)" 26.1 15.6 45.2 5.1 61.6 14.5 7.4 25.4 91.3 17.5 23.5 5.7 3.6 14.5 18.8 9.8 15.8 13.8 6.9 60.4 24.9 20.4 3.2 8.6 5.2 29.0 36.2 14.7 7.4 10.3 25.5 4.3 31.4 22.4 5.4 18.3 4.7 24.2 2.6 4.6 5.1 15.5 24.9 7.4 6.6 26.4 39.2 3.4 20.5 4.2 4.6 14.0 18.4 55.6 2.9 4.9 155.0 4.8 4.1 3.6 5.6 3.2 2.9 2.7 1.2 3.3 4.4 7.1 5.1 1.9 3.8 9.4 1.8 4.2 4.3 4.9 4.0 5.7 7.3 4.6 3.6 2.7 3.1 4.1 1.9 3.7 5.0 5.5 3.5 4.8 5.2 27.9 1.7 3.5 4.4 3.1 8.8 0.7 3.2 4.9 4.0 2.5 10.7 16.9 9.2 8.4 3.3 5.9 2.2 5.0 8.8 3.3 7.5 6.3 6.4 3.0 2.7 8.2 5.1 4.4 9.9 3.5 3.8 3.3 0.7 1.2 0.8 0.7 1.0 1.3 0.7 1.0 0.6 1.1 1.0 1.4 4.4 1.2 0.7 1.2 1.2 0.9 45.2 61.6 25.4 91.3 60.4 24.9 29.0 36.2 31.4 24.9 39.2 55.6 4.3 22.4 33.8 902.0 1.6 0.8 15.7 5.5 4.0 26.1 3.2 3.7 1.6 8.6 12.8 22.0 6.2 0.3 0.1 0.0 11.7 2.4 219.5 61.1 25.1 1.3 2.4 0.0 1018.9 0.0 0.5 16.9 2.0 7.1 2.5 6.2 1.1 0.0 0.3 38.7 727.8 0.0 4.1 0.3 0.0 400.5 26.4 1.5 1.8 185.5 0.0 15.7 0.0 596.6 302.8 2.0 0.0 54.9 0.1 7.6 0.0 22.6 68.9 10.8 6.6 7.2 18.5 10.5 5.5 1.3 1.0 0.1 0.9 28.5 0.0 22.6 MAPKAPK3 "3pK, MAPKAP3, MK-3, MK3" ENSG00000114738 "MAPK activated protein kinase 3" Q16644 3 50611520-50649291 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 4 "bone marrow: 106.5;heart muscle: 256.3;skeletal muscle: 224.2;tongue: 284.3" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 226.6;Hofbauer cells: 102.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 5 "dendritic cells: 142.8;granulocytes: 126.3;monocytes: 341.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA058275 Supported Nucleoplasm NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 32: U-937 - Innate immune response" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm "HPA058275: AB_2683663" "unprognostic (6.46e-3)" "unprognostic (1.84e-1)" "prognostic favorable (8.08e-5)" "unprognostic (1.17e-1)" "unprognostic (1.93e-1)" "unprognostic (9.96e-2)" "unprognostic (8.77e-3)" "unprognostic (7.68e-3)" "unprognostic (1.11e-1)" "unprognostic (5.87e-2)" "unprognostic (2.19e-3)" "unprognostic (1.01e-1)" "prognostic favorable (1.90e-8)" "unprognostic (2.15e-2)" "unprognostic (1.22e-1)" "unprognostic (1.86e-1)" "unprognostic (1.69e-1)" 15.3 43.3 18.0 29.8 19.6 106.5 15.8 19.2 19.2 15.0 21.3 19.7 30.2 11.3 10.3 49.6 15.1 12.1 256.3 18.0 19.7 40.0 18.7 28.2 21.7 23.6 20.5 14.2 36.2 47.2 23.5 13.9 22.5 18.4 20.0 4.7 27.7 12.6 224.2 53.4 24.2 15.9 21.6 25.3 27.6 9.2 21.1 42.0 41.2 284.3 24.2 20.3 22.2 21.6 99.6 30.3 12.4 35.9 18.4 45.7 27.9 23.8 33.7 35.7 30.3 47.1 90.2 39.8 23.5 79.5 88.5 34.6 85.9 92.7 31.9 88.3 22.3 209.5 40.6 43.5 36.8 152.1 106.4 36.9 57.0 83.1 112.2 35.6 31.9 70.2 59.7 25.4 76.1 40.5 65.3 153.3 46.4 34.6 127.0 28.5 29.9 60.1 165.5 56.2 23.0 16.5 21.3 58.9 27.7 20.6 37.8 93.4 23.8 28.1 64.5 146.4 59.5 17.2 33.7 33.1 148.3 234.7 11.8 45.3 169.5 126.3 27.6 271.6 27.3 15.1 30.9 32.1 142.8 8.8 23.9 27.8 104.4 42.1 341.5 91.2 28.0 132.6 18.0 19.6 19.2 19.2 18.0 19.7 23.6 20.5 22.5 21.6 21.1 21.6 3.5 9.6 14.0 8.5 8.6 11.3 26.9 14.0 19.4 1.1 15.3 12.3 226.6 15.7 10.4 11.0 0.0 6.0 38.1 16.2 64.6 45.6 34.5 3.4 2.7 7.1 6.0 19.1 0.3 30.4 7.4 14.9 11.7 5.4 36.2 8.3 5.3 14.2 102.1 0.0 0.7 15.4 10.2 68.0 23.9 86.2 7.2 59.4 7.2 0.0 76.6 17.1 41.2 0.5 2.0 76.2 15.6 3.4 12.7 30.9 30.7 35.4 5.7 2.3 26.3 9.7 12.0 4.1 4.6 34.2 20.2 5.1 24.3 22.0 28.2 33.5 MAPT "DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, PPP1R103, tau" ENSG00000186868 "Microtubule associated protein tau" P10636 17 45894527-46028334 "Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Alzheimer disease, Disease variant, FDA approved drug targets, Neurodegeneration, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 67.7;skeletal muscle: 79.0" "Cell type enhanced" "Detected in many" "Astrocytes: 142.4;Bipolar cells: 314.4;Early spermatids: 199.9;Excitatory neurons: 189.2;Horizontal cells: 361.7;Inhibitory neurons: 153.7;Late spermatids: 416.6;Muller glia cells: 145.7;Oligodendrocytes: 163.8" "Cancer enhanced" "Detected in many" "breast cancer: 9.5;glioma: 13.3" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "non-classical monocyte: 1.7" "Low lineage specificity" "Detected in single" "Group enriched" "Detected in many" 5 "HDLM-2: 69.0;SCLC-21H: 21.1;T-47d: 34.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000151, HPA048895, HPA069524, HPA069570, CAB072344" Enhanced Supported "Nuclear speckles,Plasma membrane" "Secreted to blood" NA NA 7100 "Cluster 35: T-regs - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 44: HDLM-2 - Immune response" "Cluster 62: Horizontal cells - Visual perception" "Plasma membrane" "Nuclear speckles" "CAB000151: , CAB072344: , HPA048895: AB_2680550, HPA069524: AB_2686145, HPA069570: AB_2686155" "unprognostic (1.78e-3)" "unprognostic (7.51e-2)" "unprognostic (3.71e-2)" "unprognostic (8.40e-5)" "unprognostic (1.40e-1)" "unprognostic (1.31e-2)" "unprognostic (4.06e-5)" "unprognostic (6.04e-2)" "unprognostic (2.19e-2)" "unprognostic (3.49e-2)" "unprognostic (3.88e-3)" "unprognostic (2.65e-1)" "unprognostic (1.72e-3)" "unprognostic (6.53e-2)" "unprognostic (3.43e-1)" "unprognostic (1.85e-2)" "unprognostic (5.47e-2)" 4.7 4.3 26.2 0.3 27.1 0.0 9.1 8.3 67.7 2.4 0.0 8.4 0.5 1.0 0.2 8.4 1.0 0.8 9.4 30.0 20.4 14.7 0.6 0.8 0.3 11.6 11.4 0.6 1.5 2.9 29.5 3.4 22.4 5.4 0.3 17.6 8.5 3.4 79.0 6.3 1.8 0.3 2.7 0.4 1.7 20.3 14.8 0.4 0.9 27.4 0.2 10.2 2.3 19.7 2.9 0.5 0.3 6.4 0.3 0.9 1.8 0.1 0.3 0.1 0.0 0.2 0.0 0.0 0.6 0.4 0.5 0.1 2.3 0.3 0.0 69.0 3.4 0.0 0.3 4.2 0.0 0.1 0.1 0.0 0.5 0.1 0.3 0.1 0.0 4.4 0.7 3.6 0.0 7.7 1.0 0.2 0.2 0.7 2.0 0.0 4.0 8.5 0.0 9.1 21.1 9.1 2.5 0.0 1.8 1.0 34.7 0.1 0.1 0.3 0.8 1.7 0.3 0.9 0.3 0.0 0.6 2.0 0.5 0.1 0.0 0.0 0.2 0.7 0.2 0.0 0.1 0.5 0.0 0.0 0.2 0.3 0.2 0.1 1.7 0.0 0.7 0.0 26.2 27.1 8.3 67.7 30.0 20.4 11.6 11.4 22.4 2.7 14.8 19.7 1.9 0.0 9.8 142.4 1.0 1.0 1.4 0.2 1.2 314.4 26.7 21.2 35.2 0.0 0.1 1.8 64.6 0.2 0.4 0.1 7.9 0.5 199.9 0.4 1.7 1.8 0.0 0.0 189.2 0.4 9.1 3.7 0.5 1.3 4.5 1.6 1.1 0.5 0.3 361.7 153.7 0.0 2.0 0.6 1.7 416.6 2.8 0.8 5.4 8.4 0.7 145.7 0.0 129.7 163.8 0.6 0.0 2.6 0.1 2.5 0.1 76.1 0.0 28.3 0.0 28.2 6.0 18.4 8.1 22.7 3.3 0.3 1.5 0.8 0.3 0.6 MARCHF6 "MARCH-VI, MARCH6, RNF176, TEB4" ENSG00000145495 "Membrane associated ring-CH-type finger 6" O60337 5 10353695-10440388 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase Epilepsy "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Adipocytes: 38.5;Cardiomyocytes: 102.5;Cytotrophoblasts: 54.4;dendritic cells: 25.8;Extravillous trophoblasts: 30.0;Hofbauer cells: 36.4;Syncytiotrophoblasts: 81.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040841, HPA063246" Approved Supported "Endoplasmic reticulum" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 3: T-cells - Adaptive immune response" "Cluster 20: HeLa - Mitochondria" "Cluster 24: Non-specific - Transcription regulation" "Endoplasmic reticulum" "HPA040841: AB_2677162, HPA063246: AB_2684970" "unprognostic (3.31e-2)" "unprognostic (2.04e-1)" "unprognostic (2.85e-2)" "unprognostic (3.80e-3)" "unprognostic (4.00e-1)" "unprognostic (2.26e-1)" "unprognostic (3.06e-2)" "unprognostic (9.52e-3)" "unprognostic (1.53e-1)" "unprognostic (1.05e-3)" "unprognostic (3.94e-2)" "unprognostic (5.58e-2)" "unprognostic (5.08e-3)" "unprognostic (1.61e-1)" "unprognostic (2.88e-1)" "unprognostic (3.57e-1)" "unprognostic (8.50e-3)" 22.1 25.5 16.1 20.3 23.7 76.5 25.9 28.3 20.7 20.1 2.9 26.9 32.8 22.7 25.5 20.9 24.9 24.5 30.8 22.0 30.4 34.1 32.5 25.1 24.7 13.7 17.5 36.0 39.3 62.4 20.8 22.8 16.9 22.7 19.8 36.6 25.6 23.8 48.4 24.8 30.3 18.9 13.8 28.2 30.2 29.9 27.9 32.3 29.3 51.8 23.3 23.7 18.6 33.5 37.4 55.1 90.1 69.9 50.6 40.4 73.7 57.7 53.7 48.9 61.8 52.8 97.0 39.4 85.4 54.4 67.2 52.3 48.2 37.7 65.4 82.9 43.0 50.7 179.7 36.2 35.6 61.4 54.6 47.4 40.6 49.0 53.1 50.0 45.8 41.4 62.1 85.1 45.0 42.4 33.1 47.2 32.8 29.9 38.5 50.9 37.6 57.0 38.0 72.4 38.7 56.0 107.2 57.9 38.4 41.3 48.2 32.5 44.8 58.4 56.8 29.1 43.7 59.3 94.1 55.7 43.1 40.7 42.8 15.6 7.4 12.6 11.2 8.4 12.8 11.7 10.8 11.0 6.3 9.6 12.5 12.4 12.1 9.1 11.1 5.0 10.4 9.1 16.1 23.7 28.3 20.7 22.0 30.4 13.7 17.5 16.9 13.8 27.9 33.5 38.5 0.0 0.0 0.0 13.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 102.5 0.0 0.0 0.0 0.0 54.4 25.8 0.0 0.0 0.0 0.0 0.0 0.0 10.4 0.0 0.0 0.0 0.0 30.0 19.3 0.0 0.0 0.0 0.0 0.0 0.0 36.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.0 0.0 0.0 0.0 0.0 81.3 5.8 0.0 0.0 0.0 MARS1 "CMT2U, MARS, MetRS, SPG70" ENSG00000166986 "Methionyl-tRNA synthetase 1" P56192 12 57475445-57517569 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Protein biosynthesis" "Aminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding" "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 11.9;Cytotrophoblasts: 29.5;Extravillous trophoblasts: 22.0;Hofbauer cells: 19.3;Syncytiotrophoblasts: 38.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RH-30: 738.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004125, CAB017097" Supported Approved Enhanced Cytosol NA NA 23000 "Cluster 27: Non-specific - Gene expression" "Cluster 35: Non-specific - Unknown function" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 24: Non-specific - Transcription regulation" Cytosol "CAB017097: , HPA004125: AB_1079312" "prognostic unfavorable (1.73e-4)" "unprognostic (2.21e-1)" "unprognostic (1.56e-1)" "unprognostic (1.09e-1)" "unprognostic (1.57e-2)" "unprognostic (4.90e-3)" "prognostic unfavorable (4.55e-7)" "unprognostic (8.47e-2)" "unprognostic (1.73e-1)" "unprognostic (4.03e-2)" "unprognostic (2.85e-2)" "unprognostic (3.77e-2)" "prognostic unfavorable (1.59e-4)" "unprognostic (1.13e-2)" "unprognostic (1.96e-1)" "unprognostic (1.13e-1)" "unprognostic (2.06e-2)" 35.9 47.2 63.1 35.9 65.2 31.6 31.5 62.0 83.6 30.8 61.6 47.6 21.5 40.7 39.0 54.3 30.1 19.3 50.5 67.5 67.5 55.7 60.6 42.7 34.5 64.2 65.5 24.2 64.4 40.7 58.9 27.3 68.1 38.7 29.6 39.6 39.6 34.0 48.5 33.0 37.3 41.3 63.5 53.9 53.2 50.7 65.6 32.6 40.0 33.1 44.4 44.8 33.6 67.9 110.6 149.6 99.7 171.9 107.1 64.6 180.2 149.0 178.4 158.1 168.6 162.9 119.0 192.3 97.6 187.2 98.3 119.4 226.0 196.4 166.2 167.4 96.9 136.7 52.8 89.4 238.1 207.7 147.5 96.2 302.9 181.5 467.5 76.6 114.8 238.1 212.9 400.3 112.1 150.4 187.9 148.1 184.8 173.0 162.3 155.5 738.3 200.0 117.0 86.4 131.6 134.0 79.8 120.9 215.8 109.6 161.0 260.7 86.9 57.5 162.8 82.8 91.6 357.5 395.8 232.5 139.7 154.8 199.1 29.9 29.8 39.3 35.1 53.6 31.7 24.4 23.4 32.0 57.9 14.7 20.0 27.4 14.5 30.0 45.6 55.9 26.3 34.2 63.1 65.2 62.0 83.6 67.5 67.5 64.2 65.5 68.1 63.5 65.6 67.9 5.8 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.9 0.0 0.0 0.0 0.0 29.5 7.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 22.0 4.4 0.0 0.0 0.0 0.0 0.0 0.0 19.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 38.0 1.2 0.0 0.0 0.0 MARVELD2 "DFNB49, FLJ30532, MRVLDC2, TRIC" ENSG00000152939 "MARVEL domain containing 2" Q8N4S9 5 69415065-69444330 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Hearing "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "thyroid gland: 15.7" "Cell type enhanced" "Detected in many" "Urothelial cells: 46.9" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 29.5;CAPAN-2: 24.1;HaCaT: 18.9;RT4: 21.1;SCLC-21H: 26.7;T-47d: 18.3" "Region enriched" "Detected in some" 8 "cerebellum: 7.9" "Low region specificity" "Detected in all" "HPA018119, HPA061726" Uncertain Supported "Cell Junctions" NA NA "Cluster 11: Basophils - Unknown function" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 28: BEWO - Transcription regulation" "Cluster 22: Epithelial cell types - Mixed function" "Cell Junctions" "HPA018119: AB_2669771, HPA061726: AB_2684595" "unprognostic (4.11e-2)" "unprognostic (3.05e-1)" "unprognostic (1.22e-2)" "unprognostic (2.44e-3)" "unprognostic (1.68e-1)" "unprognostic (1.17e-1)" "unprognostic (2.49e-1)" "unprognostic (8.84e-2)" "unprognostic (2.43e-1)" "unprognostic (3.47e-2)" "unprognostic (2.60e-2)" "unprognostic (1.75e-1)" "prognostic favorable (2.84e-13)" "unprognostic (1.78e-1)" "unprognostic (1.19e-1)" "unprognostic (3.67e-2)" "unprognostic (1.82e-1)" 0.3 0.2 0.5 0.9 0.5 0.2 4.0 0.5 0.6 2.1 3.2 5.7 7.7 1.1 1.3 6.9 3.9 2.9 0.4 0.5 0.5 8.0 10.7 5.6 0.1 0.7 0.7 0.1 9.3 4.6 2.9 1.8 0.7 3.0 6.2 0.3 4.6 2.6 0.0 4.3 7.7 0.4 0.4 0.2 8.1 1.5 0.7 1.0 15.7 0.0 1.3 3.0 3.4 0.7 10.8 3.5 0.1 0.0 0.0 0.0 29.5 0.2 0.2 0.2 0.7 14.1 24.1 0.1 2.0 1.8 0.0 18.9 0.0 14.0 0.5 0.2 5.8 0.0 1.1 7.8 1.7 0.0 0.1 0.4 15.3 0.1 1.9 0.7 0.9 0.1 0.0 0.1 0.0 9.8 0.0 0.0 1.8 6.3 0.3 0.0 0.1 0.5 10.0 21.1 26.7 0.0 2.3 2.0 0.3 4.3 18.3 0.0 1.5 0.0 0.1 0.0 0.0 0.1 3.5 0.0 0.0 0.2 0.0 0.2 0.1 0.0 0.0 0.0 0.1 0.2 0.3 0.0 0.0 0.1 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.5 0.5 0.5 0.6 0.5 0.5 0.7 0.7 0.7 0.4 0.7 0.7 1.0 22.4 26.5 0.7 1.0 5.0 22.2 14.8 10.2 0.3 15.5 8.5 2.8 35.8 23.1 16.5 2.1 22.9 0.2 31.4 17.6 25.1 5.8 33.5 3.4 4.1 16.8 3.4 0.5 25.8 8.2 1.1 17.9 30.4 1.3 3.7 5.0 37.9 1.9 0.0 0.4 23.1 18.3 0.6 0.9 3.2 0.0 0.6 1.8 1.0 7.8 0.5 0.0 0.5 0.6 25.0 29.7 0.0 0.6 25.5 33.5 6.1 38.4 0.6 0.0 0.8 1.5 4.1 2.4 19.4 6.5 12.0 0.9 2.9 25.6 46.9 MATR3 "KIAA0723, MGC9105, MPD2, VCPDM" ENSG00000015479 "Matrin 3" P43243 5 139293674-139331677 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Immunity, Innate immunity" RNA-binding "Amyotrophic lateral sclerosis, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 155.9;Inhibitory neurons: 160.2;Langerhans cells: 122.3;Oligodendrocyte precursor cells: 117.6;Oligodendrocytes: 162.4;Respiratory ciliated cells: 127.9" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "CAB033552, HPA036564, HPA036565" Supported Approved Nucleoplasm "Intracellular and membrane" NA NA 260000 "Cluster 44: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 48: Smooth muscle cells - ECM organization" Nucleoplasm "CAB033552: AB_2281755, HPA036564: AB_10669907, HPA036565: AB_10673623" "unprognostic (9.33e-2)" "unprognostic (6.57e-2)" "unprognostic (8.37e-2)" "unprognostic (7.53e-2)" "unprognostic (7.20e-2)" "unprognostic (4.32e-3)" "unprognostic (1.03e-1)" "unprognostic (3.56e-2)" "unprognostic (2.96e-2)" "unprognostic (1.93e-1)" "unprognostic (1.23e-1)" "unprognostic (9.36e-2)" "unprognostic (1.08e-3)" "unprognostic (1.73e-1)" "unprognostic (1.93e-1)" "unprognostic (3.86e-2)" "unprognostic (7.90e-2)" 112.9 127.9 145.2 93.6 156.1 323.5 161.0 172.2 224.5 144.1 109.6 106.3 76.9 166.6 124.0 103.3 131.1 115.3 111.4 158.4 146.1 150.1 112.9 115.2 157.9 126.2 132.1 199.3 102.8 168.6 95.1 122.9 131.4 130.2 106.5 223.4 93.5 133.2 119.6 82.0 90.0 142.4 144.8 124.5 89.1 114.9 139.3 221.7 190.5 114.0 170.2 133.5 91.2 156.3 209.0 191.1 559.5 260.7 192.4 212.5 283.2 172.2 300.9 300.4 347.5 273.1 208.8 351.2 236.8 244.1 284.8 135.8 376.8 269.6 403.0 278.4 189.1 236.5 205.0 285.0 183.2 262.5 174.4 222.5 203.7 247.4 226.3 247.1 296.1 219.4 216.9 170.3 313.8 186.7 496.0 285.8 303.6 205.2 182.6 304.7 416.4 217.8 278.0 316.5 279.5 348.7 248.3 176.7 264.6 426.3 194.4 254.5 192.2 272.0 177.7 180.6 246.3 171.0 300.4 423.0 189.8 226.5 268.0 187.0 71.2 116.3 109.6 82.2 134.8 116.3 114.3 124.6 92.6 97.7 124.4 116.5 34.7 150.9 106.7 50.7 136.1 159.8 145.2 156.1 172.2 224.5 158.4 146.1 126.2 132.1 131.4 144.8 139.3 156.3 0.1 44.8 50.2 83.6 17.6 114.6 0.8 99.2 15.9 1.8 0.3 0.3 0.7 0.0 92.0 0.0 2.1 1.2 0.0 27.6 0.0 0.0 0.3 0.2 0.2 13.6 83.5 15.5 155.9 0.0 1.0 17.5 5.1 0.4 100.3 0.1 0.0 0.0 1.3 1.7 160.2 35.3 87.5 0.0 122.3 0.6 0.6 4.7 103.2 60.9 0.1 0.7 0.0 117.6 162.4 0.1 12.4 0.7 7.3 0.7 0.8 0.2 127.9 1.3 0.0 1.0 33.3 1.1 0.5 15.1 111.2 0.8 21.8 0.5 41.9 1.0 MATR3 ENSG00000280987 "Matrin 3" 5 139273752-139331671 "Human disease related genes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "HPA036564, HPA036565" Supported Approved Nucleoplasm NA NA "Cluster 30: Non-specific - Translation" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 33: Fibroblasts - ECM organization" Nucleoplasm "HPA036564: AB_10669907, HPA036565: AB_10673623" "unprognostic (3.08e-1)" "unprognostic (1.96e-1)" "unprognostic (1.15e-2)" "unprognostic (2.37e-2)" "unprognostic (3.64e-1)" "unprognostic (1.10e-1)" "unprognostic (8.69e-9)" "unprognostic (1.10e-1)" "unprognostic (9.33e-3)" "unprognostic (3.09e-1)" "unprognostic (2.08e-1)" "unprognostic (5.51e-2)" "unprognostic (9.91e-10)" "unprognostic (2.91e-2)" "unprognostic (9.21e-3)" "unprognostic (2.24e-1)" "unprognostic (9.89e-2)" 10.5 13.5 14.6 24.4 14.6 25.1 31.1 9.9 24.5 9.7 5.5 22.4 16.2 15.3 34.0 17.8 19.2 9.6 30.6 15.4 12.9 10.2 9.7 8.4 36.1 18.4 10.9 14.3 7.5 8.3 2.2 10.3 18.8 15.5 29.3 11.8 26.4 8.6 41.2 20.4 12.1 14.8 13.9 19.9 17.7 18.6 13.5 17.4 9.7 38.4 33.7 14.7 2.8 21.2 81.0 58.9 30.2 162.9 65.9 79.7 58.6 42.8 36.4 69.4 87.0 101.7 71.7 284.8 60.7 61.2 45.0 91.2 257.9 136.3 120.5 48.7 125.6 190.2 100.3 89.8 57.6 176.9 67.9 93.7 95.4 79.6 90.7 38.6 78.9 103.7 143.2 50.3 74.0 31.7 98.5 53.4 122.7 35.4 38.8 199.0 92.8 125.1 40.3 55.7 92.6 56.5 49.4 60.7 113.6 77.3 57.0 71.1 56.3 52.8 78.5 43.7 63.7 23.3 33.6 153.2 45.8 148.1 61.6 0.1 0.8 0.1 0.5 1.2 1.3 3.4 1.7 2.4 3.2 2.0 2.6 1.7 0.2 0.9 0.4 0.1 1.4 1.2 14.6 14.6 9.9 24.5 15.4 12.9 18.4 10.9 18.8 13.9 13.5 21.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 MCM2 "BM28, CCNL1, cdc19, CDCL1, D3S3194, DFNA70, KIAA0030" ENSG00000073111 "Minichromosome maintenance complex component 2" P49736 3 127598410-127622436 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, DNA replication" "DNA-binding, Helicase, Hydrolase" "Cancer-related genes, Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 67.7;lymphoid tissue: 37.6" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 63.3;Erythroid cells: 65.6;Extravillous trophoblasts: 28.8;Spermatogonia: 25.9;Syncytiotrophoblasts: 33.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in some" "CAB000303, HPA031450, HPA031495, HPA031496" Enhanced Enhanced Nucleoplasm Yes Yes 120000 "Cluster 43: B-cells - Humoral immune response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "CAB000303: AB_322519, HPA031450: , HPA031495: AB_2673904, HPA031496: AB_2673905" "unprognostic (2.43e-1)" "prognostic favorable (4.66e-4)" "unprognostic (4.44e-2)" "unprognostic (3.12e-3)" "unprognostic (1.68e-1)" "unprognostic (2.25e-2)" "prognostic unfavorable (1.51e-7)" "unprognostic (8.43e-3)" "unprognostic (1.92e-2)" "unprognostic (1.79e-1)" "unprognostic (1.41e-3)" "unprognostic (1.21e-2)" "unprognostic (1.16e-2)" "unprognostic (8.16e-3)" "unprognostic (1.56e-1)" "unprognostic (3.29e-2)" "unprognostic (2.82e-1)" 3.1 3.4 2.0 16.4 1.9 67.7 6.2 2.5 1.9 5.3 0.6 9.2 8.1 5.0 2.4 11.0 7.6 2.5 6.4 1.9 1.8 3.4 6.3 3.4 26.8 2.3 1.9 6.4 3.0 3.7 2.4 17.0 2.6 5.0 10.2 3.5 4.7 2.8 9.4 10.6 8.6 5.3 2.0 9.6 5.7 12.3 2.0 37.6 4.8 5.8 26.0 4.2 5.4 2.4 133.6 110.3 122.4 102.1 7.0 14.4 110.5 65.2 42.3 129.9 146.9 177.7 84.7 136.0 65.2 32.3 113.6 105.6 204.8 76.1 79.1 127.2 127.1 227.4 134.8 131.1 4.4 214.3 102.4 8.2 8.4 86.1 13.1 15.3 40.6 160.7 116.0 123.7 47.4 169.0 229.0 156.2 172.5 108.3 90.7 242.4 165.1 203.3 26.9 97.9 143.0 106.8 175.8 48.9 16.7 45.7 111.9 165.3 20.3 104.2 87.9 128.4 91.7 127.1 163.5 362.6 73.2 159.7 41.0 0.0 0.6 0.3 4.4 1.4 5.5 9.7 3.9 5.4 2.9 8.1 3.6 4.7 0.9 6.5 0.4 3.7 11.2 3.5 2.0 1.9 2.5 1.9 1.9 1.8 2.3 1.9 2.6 2.0 2.0 2.4 1.2 3.2 2.0 0.7 8.5 4.6 2.6 4.6 2.2 2.5 4.1 5.3 8.3 0.0 3.9 0.0 0.0 63.3 1.8 4.8 0.0 5.3 0.9 5.2 3.5 2.9 3.6 65.6 0.3 1.9 28.8 4.2 6.6 4.8 1.3 18.8 1.4 1.7 18.2 0.0 0.4 8.2 0.0 1.6 3.2 0.7 1.8 2.7 1.8 0.0 9.2 2.1 0.0 0.0 0.7 2.1 1.7 1.5 20.5 0.8 1.1 0.8 7.4 2.1 0.0 2.6 4.1 8.1 25.9 7.1 3.0 33.5 6.3 3.8 13.8 2.3 MCM3AP "GANP, KIAA0572, Map80, SAC3" ENSG00000160294 "Minichromosome maintenance complex component 3 associated protein" O60318 21 46235133-46286297 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters" "Immunity, mRNA transport, Protein transport, Translocation, Transport" "Acyltransferase, Transferase" "Mental retardation, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021527, HPA032103" Approved Supported "Nucleoplasm,Nuclear membrane,Cytosol" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 1: K-562 - Erythropoiesis" "Cluster 59: Non-specific - Transcription" "Nuclear membrane, Cytosol" Nucleoplasm "HPA021527: AB_1853626, HPA032103: AB_2674152" "unprognostic (1.75e-1)" "unprognostic (1.31e-1)" "unprognostic (2.31e-1)" "unprognostic (2.20e-1)" "unprognostic (1.72e-1)" "unprognostic (6.31e-3)" "unprognostic (1.48e-2)" "unprognostic (2.06e-1)" "unprognostic (4.17e-2)" "unprognostic (4.76e-3)" "prognostic favorable (2.05e-4)" "unprognostic (1.96e-1)" "unprognostic (2.81e-3)" "unprognostic (1.04e-1)" "unprognostic (1.05e-1)" "unprognostic (3.85e-3)" "unprognostic (2.28e-1)" 16.8 12.0 10.0 20.3 11.5 19.7 13.6 8.9 10.7 14.7 17.0 15.1 14.0 16.5 8.3 14.3 15.2 14.2 15.1 8.5 7.8 13.0 9.7 16.0 21.0 10.8 10.4 17.6 15.4 16.9 9.2 16.3 9.5 14.2 15.0 12.8 13.7 13.4 41.3 13.8 16.1 17.1 9.4 19.6 15.4 14.1 11.0 21.7 16.0 28.7 21.5 13.6 11.2 14.6 38.0 36.3 41.8 45.5 33.1 41.4 38.0 40.8 48.1 37.1 30.2 33.1 21.9 53.6 32.9 43.2 40.3 21.9 55.9 34.0 32.7 55.7 50.8 87.9 35.0 25.9 29.6 40.6 47.7 31.7 28.7 51.2 35.2 25.4 40.7 31.7 107.3 39.6 43.3 21.1 43.5 26.8 72.3 40.0 30.2 56.3 26.6 48.9 17.8 34.1 35.2 37.6 52.4 33.7 39.0 31.5 46.0 41.2 51.6 39.1 29.7 33.1 31.0 71.8 86.2 33.0 35.3 38.0 51.8 0.6 2.0 1.6 2.3 1.9 2.4 1.1 1.3 2.6 1.9 1.6 1.2 1.3 1.2 1.1 1.1 1.6 1.8 2.1 10.0 11.5 8.9 10.7 8.5 7.8 10.8 10.4 9.5 9.4 11.0 14.6 17.3 9.6 18.9 28.1 21.3 7.0 7.1 9.0 22.2 21.8 13.8 13.0 4.7 14.3 12.7 11.0 20.9 11.4 20.6 17.5 1.9 11.3 3.5 16.8 23.7 14.8 12.0 18.5 28.0 14.2 11.7 12.8 27.0 17.7 8.8 20.1 11.7 18.6 15.4 16.8 34.2 19.2 10.2 19.7 8.4 4.3 18.3 18.6 10.6 34.7 24.3 9.3 16.5 37.2 35.3 15.9 8.6 14.3 21.6 14.0 13.8 6.6 15.5 21.7 19.7 17.9 12.9 19.7 15.0 21.2 10.4 9.3 19.1 16.0 17.9 7.9 MDH1 ENSG00000014641 "Malate dehydrogenase 1" P40925 2 63588609-63607197 "Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Tricarboxylic acid cycle" Oxidoreductase "Cancer-related genes, Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 1349.1;tongue: 1843.8" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 1926.9;Proximal tubular cells: 1428.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027296, CAB047333, HPA054276" Uncertain Supported Centrosome,Cytosol NA NA 49000000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 39: Non-specific - Basic cellular processes" "Centrosome, Cytosol" "CAB047333: , HPA027296: AB_10611118, HPA054276: AB_2682434" "unprognostic (1.01e-1)" "unprognostic (6.52e-3)" "unprognostic (1.61e-2)" "prognostic unfavorable (7.13e-4)" "unprognostic (1.83e-1)" "unprognostic (8.84e-3)" "unprognostic (5.81e-2)" "unprognostic (2.79e-2)" "unprognostic (9.52e-2)" "unprognostic (2.05e-1)" "unprognostic (3.26e-1)" "unprognostic (8.80e-2)" "prognostic favorable (9.95e-4)" "unprognostic (6.37e-2)" "unprognostic (1.75e-1)" "unprognostic (5.97e-2)" "unprognostic (3.05e-1)" 274.6 213.6 235.9 86.7 249.7 79.1 137.9 245.9 353.6 89.6 230.2 167.7 154.7 82.0 161.3 125.3 114.5 87.2 1349.1 253.2 261.5 371.6 266.3 89.8 131.9 248.5 218.3 80.4 69.9 411.8 107.2 92.5 253.3 125.5 190.9 240.7 122.0 142.0 792.5 87.7 133.1 171.5 215.7 71.6 192.6 70.5 259.1 170.4 125.5 1843.8 165.4 131.5 62.8 237.7 268.2 219.5 257.8 173.2 369.6 280.9 282.3 215.1 295.9 300.6 304.1 252.5 215.4 355.2 112.8 264.1 358.8 214.3 303.0 355.0 425.5 207.6 253.1 337.0 173.2 376.8 202.1 384.1 223.9 277.7 241.3 271.5 152.7 236.2 235.3 308.1 183.7 217.3 395.1 157.8 300.6 317.5 158.0 376.3 266.5 235.2 349.7 310.5 460.9 251.0 249.9 153.6 182.5 257.7 384.1 205.6 191.9 341.9 149.6 220.3 211.9 187.1 252.9 264.6 264.8 407.6 266.2 312.2 184.1 271.3 186.3 200.2 202.7 267.8 218.8 258.5 236.6 224.6 241.0 258.5 230.3 221.6 28.1 214.6 253.4 184.3 320.9 321.2 235.9 249.7 245.9 353.6 253.2 261.5 248.5 218.3 253.3 215.7 259.1 237.7 44.4 60.9 54.3 54.9 78.7 81.6 109.4 562.9 50.7 165.4 81.0 86.7 1926.9 95.8 227.2 134.3 70.9 248.7 78.4 128.4 630.0 186.2 12.4 116.1 72.6 61.0 62.8 62.9 120.2 108.1 257.0 134.7 112.7 68.8 80.5 95.0 36.0 153.2 397.0 122.8 130.0 115.9 380.5 85.2 65.8 15.1 100.0 98.4 177.9 43.1 155.0 136.3 73.2 51.3 58.8 91.3 99.8 109.1 82.1 48.8 177.4 1428.3 224.5 164.1 59.2 68.3 167.8 58.0 65.6 82.7 84.0 149.5 84.3 137.4 167.8 102.6 MDH2 ENSG00000146701 "Malate dehydrogenase 2" P40926 7 76048051-76067508 "Citric acid cycle related proteins, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Tricarboxylic acid cycle" Oxidoreductase "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 697.1;tongue: 601.9" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019714, HPA019716, HPA019848, HPA026720" Enhanced Enhanced Mitochondria No No 14000000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "HPA019714: AB_1853678, HPA019716: AB_1853680, HPA019848: AB_1853683, HPA026720: AB_1853685" "unprognostic (3.20e-2)" "unprognostic (2.85e-1)" "unprognostic (1.11e-1)" "unprognostic (1.43e-2)" "unprognostic (5.55e-3)" "unprognostic (8.94e-2)" "unprognostic (6.45e-2)" "unprognostic (3.77e-2)" "unprognostic (3.60e-1)" "unprognostic (2.02e-2)" "unprognostic (1.40e-1)" "unprognostic (9.70e-2)" "prognostic favorable (1.49e-5)" "unprognostic (8.57e-2)" "unprognostic (9.64e-2)" "unprognostic (5.68e-2)" "unprognostic (2.66e-1)" 76.9 163.4 68.0 51.4 73.6 71.9 73.9 62.1 83.9 67.4 81.3 118.7 112.7 69.2 34.7 144.9 66.8 38.0 367.5 73.5 69.9 121.7 215.5 60.7 62.4 66.7 61.4 64.1 118.3 90.5 70.7 45.2 67.0 67.3 80.3 40.2 98.8 56.8 697.1 119.5 94.4 60.0 56.3 75.6 103.2 60.2 64.1 60.4 62.3 601.9 66.2 85.6 82.4 66.6 176.5 278.4 99.2 250.7 110.3 121.2 172.0 113.9 145.8 159.4 143.2 246.2 204.7 261.3 51.1 151.1 172.6 174.4 256.3 170.0 112.7 192.1 368.3 144.6 138.7 229.9 135.2 229.3 144.6 153.7 149.7 155.2 229.3 124.9 150.9 160.5 466.3 149.4 149.7 389.6 206.4 402.1 222.8 306.6 344.3 164.3 121.7 379.9 149.9 225.5 247.4 226.9 114.6 567.5 247.0 124.9 323.4 260.0 117.7 160.0 151.6 175.5 232.7 166.5 148.1 290.8 138.6 289.1 249.1 95.4 129.9 63.3 102.4 148.8 107.1 122.2 113.7 111.2 176.0 110.2 109.0 102.6 34.0 107.4 164.2 157.2 156.6 175.8 68.0 73.6 62.1 83.9 73.5 69.9 66.7 61.4 67.0 56.3 64.1 66.6 98.8 51.3 65.9 7.8 110.2 135.9 190.8 437.9 118.4 68.0 151.8 165.5 486.2 135.8 217.3 115.8 18.8 328.1 104.9 242.3 448.0 269.8 263.7 108.0 97.9 96.8 169.7 97.2 13.0 333.1 334.0 112.6 111.1 104.8 54.5 150.9 88.5 246.6 248.1 72.3 15.0 280.6 288.9 132.6 113.5 161.5 99.4 117.6 181.5 9.4 171.4 85.7 126.7 8.0 12.8 255.0 252.1 99.3 149.8 197.3 433.3 466.3 139.0 67.3 85.5 114.7 150.9 157.8 65.3 256.6 166.1 294.8 105.4 233.4 372.7 234.7 MECR "CGI-63, ETR1, FASN2B, NRBF1" ENSG00000116353 "Mitochondrial trans-2-enoyl-CoA reductase" Q9BV79 1 29192657-29230942 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Oxidoreductase "Disease variant, Dystonia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 42.1" "Cell type enhanced" "Detected in all" "Late spermatids: 82.5;Rod photoreceptor cells: 68.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022018, HPA022030, HPA028740" Enhanced Supported Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 59: Non-specific - Translation" "Cluster 25: RPMI-8226 - Immune response" "Cluster 46: Photoreceptor cells - Phototransduction" Mitochondria "HPA022018: AB_1853714, HPA022030: AB_1853716, HPA028740: AB_10601133" "unprognostic (2.53e-1)" "unprognostic (1.09e-2)" "unprognostic (1.52e-1)" "unprognostic (1.84e-1)" "unprognostic (1.07e-1)" "unprognostic (2.46e-1)" "unprognostic (1.39e-1)" "unprognostic (2.07e-1)" "unprognostic (1.34e-1)" "unprognostic (1.69e-1)" "unprognostic (3.06e-2)" "unprognostic (8.66e-2)" "prognostic favorable (5.81e-6)" "unprognostic (7.01e-3)" "unprognostic (3.29e-2)" "unprognostic (2.59e-1)" "prognostic unfavorable (5.29e-4)" 14.7 14.6 5.1 1.7 5.1 1.8 13.4 3.3 6.2 10.2 3.1 10.3 1.4 12.9 2.5 12.5 9.4 1.3 24.8 6.0 3.9 14.1 15.8 7.3 2.0 5.2 4.0 10.0 8.9 4.5 7.2 3.5 5.4 7.9 2.6 9.9 12.3 3.0 42.1 15.4 7.2 3.1 3.2 6.7 11.1 7.6 4.3 1.4 8.3 5.8 2.1 9.6 9.6 5.2 3.9 4.5 3.2 4.6 2.9 2.5 6.8 3.7 3.8 4.7 3.9 2.3 5.6 7.3 5.1 3.7 1.3 3.0 5.4 6.3 4.0 4.4 6.9 6.4 3.4 4.1 6.6 6.1 1.9 4.3 5.9 3.1 11.0 3.8 3.5 6.9 5.8 4.2 4.7 4.5 3.9 2.9 6.5 5.8 4.3 3.5 4.2 9.3 5.9 2.4 5.1 4.5 4.1 4.7 7.0 4.4 2.3 5.4 3.8 2.4 2.9 4.1 4.7 2.7 2.2 5.0 3.9 8.4 5.2 0.1 2.2 0.0 1.5 2.1 4.1 2.2 1.6 1.7 1.9 1.1 2.3 1.6 0.3 2.9 1.6 2.5 2.4 1.2 5.1 5.1 3.3 6.2 6.0 3.9 5.2 4.0 5.4 3.2 4.3 5.2 8.8 12.8 3.9 14.7 9.1 5.6 15.6 26.9 7.4 12.8 12.0 14.6 19.8 21.5 21.4 20.2 10.4 46.0 3.8 7.4 41.1 24.3 40.8 19.7 13.6 9.1 7.8 10.1 25.1 19.7 42.4 12.8 4.6 12.8 5.7 17.5 7.1 19.7 20.8 8.4 20.3 9.4 12.2 6.0 5.1 82.5 13.7 5.3 16.0 3.7 10.8 14.5 10.3 11.6 15.2 16.3 8.0 10.9 10.3 20.6 10.9 46.0 11.3 68.5 13.1 13.2 12.9 8.5 16.1 14.0 7.4 27.9 6.0 25.8 18.3 20.5 MERTK "c-Eyk, mer, RP38, Tyro12" ENSG00000153208 "MER proto-oncogene, tyrosine kinase" Q12866 2 111898607-112029561 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Disease variant, Proto-oncogene, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 162.6;Kupffer cells: 119.8;Macrophages: 46.5;Microglial cells: 124.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 12 "intermediate monocyte: 8.6;non-classical monocyte: 5.5" "Lineage enriched" "Detected in single" 50 "monocytes: 8.6" "Cell line enhanced" "Detected in many" "CACO-2: 35.1;Hep G2: 39.9;HUVEC TERT2: 38.4;RT4: 23.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036196, HPA075622" Enhanced Approved "Endoplasmic reticulum,Plasma membrane,Midbody,Cytosol" Yes NA 65000000 "Cluster 7: Monocytes - Unknown function" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 39: CACO-2 - Unknown function" "Cluster 4: Macrophages - Innate immune response" "Plasma membrane" "Endoplasmic reticulum, Midbody, Cytosol" "HPA036196: AB_10670676, HPA075622: AB_2686759" "unprognostic (2.17e-2)" "unprognostic (8.10e-2)" "unprognostic (4.85e-2)" "unprognostic (2.68e-1)" "unprognostic (2.44e-1)" "unprognostic (1.77e-1)" "unprognostic (1.07e-1)" "prognostic favorable (4.74e-4)" "unprognostic (6.84e-2)" "unprognostic (1.25e-1)" "unprognostic (6.22e-2)" "unprognostic (3.72e-1)" "prognostic favorable (4.43e-5)" "unprognostic (5.13e-2)" "unprognostic (2.11e-1)" "unprognostic (5.86e-2)" "unprognostic (2.05e-2)" 20.1 59.8 22.8 13.5 28.0 1.5 15.3 18.0 29.3 12.6 44.7 10.9 12.3 11.5 26.3 8.4 15.5 12.0 7.0 22.0 22.5 11.4 21.0 13.6 13.1 23.5 22.3 12.6 9.9 21.2 15.5 20.1 22.4 14.1 7.9 16.6 6.4 16.3 3.2 6.4 14.3 14.4 18.4 30.6 13.9 17.2 30.1 6.8 10.1 4.6 8.9 13.6 9.4 22.0 1.0 1.7 7.6 17.3 0.4 0.2 12.3 0.0 0.2 1.0 1.7 35.1 2.2 0.1 8.1 0.1 7.9 0.2 10.2 0.0 1.4 1.5 5.5 7.0 0.0 39.9 0.3 0.2 1.5 0.5 0.0 8.9 0.6 4.0 38.4 1.5 2.2 3.5 2.9 1.8 0.0 9.1 4.8 1.1 6.0 2.9 2.1 3.0 19.4 23.4 0.3 7.2 0.2 0.5 3.2 2.7 0.0 0.4 5.8 1.0 3.4 0.1 0.0 3.1 4.8 0.1 0.0 1.4 0.0 0.0 0.6 0.0 0.0 8.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 5.5 0.1 0.0 0.2 22.8 28.0 18.0 29.3 22.0 22.5 23.5 22.3 22.4 18.4 30.1 22.0 8.8 3.2 27.7 162.6 1.7 1.7 2.9 0.3 1.8 0.6 2.1 4.3 2.7 2.8 6.4 0.0 2.1 3.3 0.4 1.2 1.9 1.1 2.3 8.0 4.7 10.2 0.0 0.4 5.0 1.0 1.1 3.2 0.5 12.1 0.0 3.8 28.5 9.2 25.5 0.0 7.0 2.0 0.0 119.8 1.8 2.7 5.0 46.5 0.0 124.6 1.5 7.7 0.0 10.6 0.6 1.2 1.9 6.8 10.8 2.9 4.4 1.9 1.5 11.3 6.6 1.5 9.2 0.6 1.5 0.6 1.3 18.9 1.3 3.5 1.9 1.6 MET "DFNB97, HGFR, RCCP2" ENSG00000105976 "MET proto-oncogene, receptor tyrosine kinase" P08581 7 116672196-116798377 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Deafness, Disease variant, FDA approved drug targets, Non-syndromic deafness, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 42.9" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 103.6;Club cells: 99.8;Glandular and luminal cells: 161.4;Pancreatic endocrine cells: 93.9;Prostatic glandular cells: 149.3;Urothelial cells: 128.6" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in many" 5 "cerebral cortex: 7.5;hippocampal formation: 6.6;midbrain: 2.5;pons: 4.9;white matter: 7.8" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 203.8;CAPAN-2: 219.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB005282, CAB018577, HPA055607" Approved Approved "Plasma membrane,Cytosol" "Secreted to blood" NA NA 179000000 100000000 "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 44: Endometrium - Transcription" "Plasma membrane, Cytosol" "CAB005282: AB_631940, CAB018577: AB_649068, HPA055607: AB_2682860" "unprognostic (1.60e-2)" "unprognostic (7.71e-2)" "unprognostic (2.53e-2)" "unprognostic (1.58e-1)" "unprognostic (3.57e-3)" "prognostic unfavorable (6.75e-4)" "unprognostic (1.68e-1)" "unprognostic (3.22e-2)" "unprognostic (3.81e-2)" "unprognostic (2.52e-2)" "prognostic unfavorable (1.21e-7)" "unprognostic (1.86e-1)" "unprognostic (1.25e-1)" "unprognostic (5.53e-2)" "unprognostic (8.88e-2)" "unprognostic (2.01e-2)" "unprognostic (2.20e-1)" 10.3 0.8 0.1 3.4 0.6 7.4 8.9 0.1 7.5 13.1 9.6 9.7 6.5 6.4 2.5 6.1 4.7 11.9 6.2 6.6 0.8 20.1 42.9 20.3 2.3 1.1 2.5 0.8 6.6 0.8 3.8 26.4 4.9 6.7 9.3 3.9 8.7 11.2 14.3 7.7 8.2 5.7 0.3 6.0 15.4 0.5 0.5 3.7 17.6 11.0 3.2 18.4 4.4 7.8 203.8 115.3 0.1 0.6 8.6 8.7 7.9 113.7 48.2 60.3 51.1 25.0 219.0 8.4 179.0 72.1 163.3 51.8 19.7 110.0 123.7 0.3 23.4 0.1 112.5 21.4 1.5 0.3 0.2 11.4 42.4 40.6 129.1 109.4 42.4 0.2 4.5 0.8 114.1 5.0 0.1 0.1 17.3 32.9 113.0 0.2 95.3 0.2 105.8 24.0 16.5 0.0 45.4 15.4 44.9 19.8 0.4 0.9 72.3 89.7 30.6 46.7 88.9 2.5 19.1 1.5 99.3 0.3 12.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.1 7.5 6.6 0.8 1.1 2.5 4.9 0.3 0.5 7.8 32.6 28.9 103.6 0.3 1.0 39.0 70.5 58.1 38.1 6.7 6.5 6.9 12.3 11.5 99.8 31.3 0.0 76.0 0.4 20.5 0.0 38.5 0.0 52.5 11.6 20.1 7.2 0.0 2.6 46.9 7.5 7.4 32.6 161.4 0.0 0.0 3.9 30.5 7.0 0.0 1.0 20.5 18.3 1.3 2.2 0.1 0.6 4.4 3.6 1.9 1.0 7.6 0.0 0.5 7.7 93.9 5.5 0.0 0.4 149.3 11.2 15.6 34.5 0.3 0.0 37.8 5.2 0.0 0.6 7.9 17.8 21.8 1.2 0.0 16.4 128.6 MFN2 "CMT2A2, CPRP1, KIAA0214, MARF" ENSG00000116688 "Mitofusin 2" O95140 1 11980181-12015211 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Apoptosis, Autophagy, Unfolded protein response" Hydrolase "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 270.4;skeletal muscle: 310.5;tongue: 337.6" "Cell type enriched" "Detected in all" 7 "Cardiomyocytes: 336.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030554, CAB079902" Uncertain Supported Mitochondria NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 8: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 54: Cardiomyocytes - Muscle contraction" Mitochondria "CAB079902: AB_2724683, HPA030554: AB_10603018" "unprognostic (9.52e-2)" "unprognostic (1.80e-1)" "unprognostic (1.42e-1)" "unprognostic (4.38e-2)" "unprognostic (8.36e-2)" "unprognostic (9.71e-2)" "unprognostic (1.89e-1)" "unprognostic (2.44e-1)" "unprognostic (3.45e-1)" "unprognostic (2.19e-2)" "unprognostic (1.43e-1)" "unprognostic (3.55e-1)" "prognostic favorable (2.36e-8)" "unprognostic (4.69e-2)" "unprognostic (2.76e-1)" "unprognostic (8.84e-3)" "unprognostic (2.12e-1)" 34.7 31.4 39.9 20.9 42.4 26.7 31.8 39.1 41.4 29.3 17.4 59.7 41.9 37.0 12.7 57.3 26.2 21.8 270.4 34.7 43.0 36.5 58.5 31.1 19.8 41.1 44.8 27.0 22.5 76.7 28.7 27.6 40.6 36.3 38.1 35.0 32.2 62.3 310.5 58.9 46.3 41.2 43.5 31.5 44.9 25.4 48.8 26.1 56.1 337.6 30.4 51.2 36.2 40.5 93.6 54.0 52.6 72.7 59.7 47.2 58.8 76.0 66.1 96.5 72.6 88.7 51.8 68.8 74.8 92.6 60.6 80.5 101.7 156.1 90.6 60.6 75.4 94.5 81.8 54.2 53.8 114.2 51.9 57.0 105.1 133.1 124.5 40.1 66.2 26.4 106.1 53.6 69.7 30.2 60.2 15.2 39.7 57.8 77.4 68.2 95.8 58.5 44.9 61.4 68.2 44.6 88.4 81.0 74.6 41.4 43.8 49.2 71.2 63.1 58.3 88.4 71.2 59.0 86.4 120.7 69.0 99.6 69.8 10.4 11.5 7.6 8.9 14.0 10.2 6.7 6.7 7.9 9.7 4.8 5.0 6.2 16.2 6.2 18.3 4.2 8.1 15.7 39.9 42.4 39.1 41.4 34.7 43.0 41.1 44.8 40.6 43.5 48.8 40.5 18.1 22.4 15.8 16.6 10.2 22.8 9.4 18.9 19.9 26.7 17.4 16.4 336.9 7.2 14.9 14.7 12.5 15.1 12.5 39.2 21.5 13.6 4.7 8.9 12.1 18.5 18.0 32.4 21.5 20.4 15.5 17.3 17.3 12.8 10.8 12.8 11.7 46.3 16.0 30.3 24.5 22.2 18.3 23.9 9.7 8.0 7.2 19.1 17.8 8.4 17.3 14.6 8.2 11.1 16.7 18.5 16.8 15.1 10.9 13.9 41.8 14.3 12.9 21.0 13.1 16.0 16.5 25.9 15.6 25.1 30.1 25.2 10.3 12.5 26.4 16.6 MIP "AQP0, LIM1, MP26" ENSG00000135517 "Major intrinsic protein of lens fiber" P30301 12 56449502-56469166 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Sensory transduction, Transport, Vision" "Eye lens protein" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "Early spermatids: 2.6;Horizontal cells: 1.7;Late spermatids: 2.8;Spermatocytes: 7.3;Spermatogonia: 1.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA014940 Supported NA NA "Cluster 66: Spermatocytes - Spermatogenesis" "HPA014940: AB_2669122" "unprognostic (6.48e-2)" "unprognostic (6.12e-2)" "unprognostic (2.23e-1)" "unprognostic (1.62e-1)" "unprognostic (7.14e-2)" "unprognostic (3.96e-2)" "unprognostic (2.90e-3)" "unprognostic (1.72e-1)" "unprognostic (3.47e-1)" "unprognostic (1.51e-5)" "unprognostic (4.56e-3)" "unprognostic (6.75e-2)" "unprognostic (1.16e-2)" "unprognostic (2.83e-2)" "unprognostic (3.27e-1)" "unprognostic (2.62e-1)" "unprognostic (8.82e-2)" 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.2 0.3 0.4 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 2.6 0.1 0.1 0.3 0.0 0.0 0.1 0.2 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.8 0.0 1.7 0.1 0.2 0.0 0.0 0.3 2.8 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.7 0.0 0.0 0.1 7.3 1.6 0.0 0.0 0.3 0.0 0.3 0.0 0.1 MLC1 "KIAA0027, LVM, MLC, VL" ENSG00000100427 "Modulator of VRAC current 1" Q15049 22 50059391-50085426 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Ion channel" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "brain: 262.7;choroid plexus: 145.6" "Cell type enriched" "Detected in some" 6 "Astrocytes: 115.6" "Cancer enriched" "Detected in some" 69 "glioma: 122.0" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "NK-cell: 20.2" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "HL-60: 228.2;NB-4: 219.8;THP-1: 401.5;U-266/70: 131.6;U-266/84: 120.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003040 Enhanced Supported Cytosol NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 43: THP-1 - Innate immune response" "Cluster 64: Astrocytes - Nervous system maintenance" Cytosol "HPA003040: AB_1079387" "unprognostic (2.68e-2)" "unprognostic (5.46e-6)" "unprognostic (5.41e-3)" "unprognostic (1.51e-1)" "unprognostic (1.47e-1)" "unprognostic (2.42e-3)" "unprognostic (9.54e-3)" "unprognostic (7.21e-2)" "unprognostic (2.24e-1)" "unprognostic (1.90e-1)" "unprognostic (1.31e-1)" "unprognostic (1.51e-3)" "unprognostic (8.39e-4)" "unprognostic (1.40e-1)" "unprognostic (1.55e-1)" "unprognostic (3.66e-2)" "unprognostic (2.92e-1)" 0.3 0.1 239.3 0.7 235.7 36.4 0.1 212.7 261.8 3.0 145.6 0.1 0.4 0.3 1.0 0.1 1.8 1.0 0.6 225.8 234.5 0.1 0.4 1.6 0.3 262.7 243.1 0.3 0.1 0.0 1.1 2.3 221.8 4.8 0.0 4.1 0.1 1.4 0.1 1.0 0.1 0.2 231.9 2.2 0.2 3.8 231.5 0.5 0.1 0.0 0.5 0.4 11.9 217.2 0.4 0.0 2.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 68.1 0.0 0.0 0.1 228.2 68.4 0.0 0.6 0.0 0.0 0.0 0.0 0.2 0.0 0.5 0.0 0.0 1.8 219.8 0.3 0.0 0.1 24.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.5 0.0 401.5 0.0 0.0 0.2 0.1 0.3 131.6 120.2 0.4 0.3 35.7 2.2 0.0 1.1 0.0 3.9 6.8 0.1 0.1 0.3 1.6 0.9 0.0 0.1 1.8 0.1 20.2 9.2 0.2 0.1 4.0 239.3 235.7 212.7 261.8 225.8 234.5 262.7 243.1 221.8 231.9 231.5 217.2 0.0 0.0 0.5 115.6 0.3 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.7 0.0 0.6 0.0 0.0 0.1 17.2 0.0 0.0 0.0 1.1 0.1 0.4 0.1 0.0 7.8 0.4 0.0 0.1 2.4 0.0 0.1 1.3 4.4 0.4 0.0 3.5 0.0 0.5 0.0 0.0 0.3 0.0 0.7 0.0 0.6 1.8 7.5 0.6 16.3 18.6 0.5 0.8 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.2 1.0 0.0 0.0 0.1 0.3 0.4 0.0 0.0 0.3 2.7 0.1 0.0 0.0 MME "CALLA, CD10, NEP" ENSG00000196549 "Membrane metalloendopeptidase" P08473 3 155024124-155183704 "Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, Charcot-Marie-Tooth disease, Disease variant, FDA approved drug targets, Neurodegeneration, Neuropathy, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 333.5;kidney: 302.5" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 273.3;Proximal enterocytes: 372.4;Proximal tubular cells: 125.7;Syncytiotrophoblasts: 126.0" "Cancer enhanced" "Detected in many" "prostate cancer: 17.6" "Group enriched" "Detected in many" 5 "basal ganglia: 17.3;medulla oblongata: 9.3;pons: 10.9;thalamus: 4.6" "Immune cell enriched" "Detected in some" 122 "neutrophil: 139.4" "Lineage enriched" "Detected in many" 122 "granulocytes: 139.4" "Cell line enhanced" "Detected in many" "ASC TERT1: 684.4;BJ hTERT+: 1116.9;HSkMC: 651.1" "Region enhanced" "Detected in many" "basal ganglia: 28.1" "Group enriched" "Detected in many" 4 "basal ganglia: 32.3;olfactory bulb: 8.5;spinal cord: 15.9" "CAB000013, HPA052583, HPA056072" Enhanced NA NA 320000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 45: Enterocytes - Digestion" "CAB000013: AB_563478, HPA052583: AB_2681872, HPA056072: AB_2683027" "unprognostic (1.36e-1)" "unprognostic (1.02e-3)" "unprognostic (8.52e-2)" "unprognostic (2.95e-1)" "unprognostic (2.78e-2)" "unprognostic (6.52e-3)" "unprognostic (1.20e-1)" "unprognostic (1.67e-2)" "unprognostic (8.67e-2)" "unprognostic (1.96e-1)" "unprognostic (7.30e-3)" "unprognostic (1.31e-1)" "unprognostic (2.71e-3)" "unprognostic (1.50e-1)" "unprognostic (7.29e-2)" "unprognostic (1.06e-2)" "unprognostic (1.37e-2)" 103.9 1.0 0.7 4.5 17.3 11.5 38.5 1.5 1.9 22.7 0.3 1.9 333.5 13.3 22.5 2.3 1.9 13.4 4.3 0.1 0.6 302.5 56.1 27.6 10.3 9.3 2.3 0.9 1.2 0.5 0.6 73.0 10.9 79.6 3.4 0.1 6.1 44.5 20.3 1.9 289.7 1.5 0.9 7.9 1.6 1.3 4.6 16.6 1.2 23.5 12.3 6.0 7.6 0.4 0.1 0.0 0.9 0.3 280.1 684.4 1.6 160.3 1116.9 82.2 209.8 0.0 0.3 172.9 0.1 130.1 107.4 0.5 5.2 6.1 201.3 0.0 0.8 0.0 0.1 0.2 229.6 0.0 0.0 651.1 1.0 40.4 308.1 89.4 59.5 0.4 0.2 0.3 135.1 0.7 0.4 1.0 6.1 0.5 1.1 303.3 139.9 1.6 5.2 1.9 0.5 1.5 0.1 0.5 31.9 68.3 0.2 0.2 165.8 356.4 0.8 115.7 27.9 0.1 0.0 217.3 42.5 0.1 7.3 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.0 139.4 0.0 0.0 1.1 0.0 0.0 0.7 17.3 1.5 1.9 0.1 0.6 9.3 2.3 10.9 0.9 4.6 0.4 5.9 9.6 13.0 0.3 2.3 0.8 74.1 2.5 0.0 0.0 1.5 64.1 1.6 21.5 11.2 22.0 0.0 82.1 6.9 0.0 9.8 0.2 0.5 6.2 273.3 6.6 0.0 0.0 2.2 0.0 57.8 40.6 0.0 5.7 2.5 0.0 2.9 53.2 8.9 0.0 8.1 9.9 2.0 3.1 1.2 0.5 4.1 10.7 0.0 0.0 0.2 0.0 0.0 0.5 0.3 0.6 13.8 1.2 0.1 40.0 372.4 125.7 1.6 0.0 0.0 17.4 11.1 0.2 0.5 0.1 0.3 126.0 2.5 0.1 12.6 33.6 MOG "BTN6, BTNL11" ENSG00000204655 "Myelin oligodendrocyte glycoprotein" Q16653 6 29657002-29672372 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Cell adhesion, Host-virus interaction" "Host cell receptor for virus entry, Receptor" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 28 "brain: 73.8" "Cell type enriched" "Detected in some" 49 "Oligodendrocytes: 472.3" "Cancer enriched" "Detected in single" 45 "glioma: 15.1" "Region enriched" "Detected in all" 4 "cerebral cortex: 73.8" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enhanced" "Detected in all" "white matter: 1396.5" "Low region specificity" "Detected in all" HPA021873 Enhanced NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA021873: AB_1854055" "unprognostic (1.33e-1)" "unprognostic (1.32e-1)" "unprognostic (1.03e-1)" "unprognostic (1.05e-2)" "unprognostic (7.87e-2)" "unprognostic (3.00e-4)" "unprognostic (4.89e-2)" "unprognostic (4.90e-2)" 0.0 0.0 4.9 0.0 11.0 0.0 0.0 8.6 73.8 0.0 2.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.6 6.8 8.4 0.1 0.0 0.0 0.0 9.9 8.4 0.1 0.0 0.0 0.3 0.0 10.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 8.1 0.0 0.0 0.0 8.4 0.0 0.0 0.0 0.0 0.0 0.0 17.8 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.9 11.0 8.6 73.8 6.8 8.4 9.9 8.4 10.1 8.1 8.4 17.8 0.0 0.0 1.1 0.7 0.1 1.0 0.4 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.8 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.8 0.0 0.0 0.3 0.7 0.0 0.0 0.2 0.0 1.0 0.1 0.0 0.0 9.5 472.3 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.8 0.2 0.1 0.1 0.0 0.9 0.0 0.3 0.0 0.0 0.3 MORC2 "AC004542.C22.1, KIAA0852, ZCW3, ZCWCC1" ENSG00000133422 "MORC family CW-type zinc finger 2" Q9Y6X9 22 30925130-30968774 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" Hydrolase "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Lineage enriched" "Detected in all" 5 "T-cells: 16.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000436, HPA077137" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 20: T-cells - T-cell receptor" "Cluster 71: Testis - DNA repair" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" Nucleoplasm Cytosol "HPA000436: AB_1079404, HPA077137: " "unprognostic (3.43e-2)" "unprognostic (1.71e-2)" "unprognostic (1.60e-3)" "unprognostic (1.44e-2)" "unprognostic (6.15e-2)" "unprognostic (3.56e-3)" "unprognostic (2.89e-3)" "unprognostic (4.63e-1)" "unprognostic (6.76e-2)" "unprognostic (1.60e-1)" "unprognostic (5.46e-3)" "unprognostic (1.32e-1)" "prognostic unfavorable (6.54e-8)" "unprognostic (5.64e-2)" "unprognostic (2.38e-1)" "unprognostic (1.02e-2)" "unprognostic (6.66e-3)" 15.6 14.4 6.6 7.0 6.7 6.6 16.6 8.5 8.3 20.6 6.6 20.7 5.3 18.1 6.8 17.0 18.7 5.3 19.2 6.6 6.5 16.7 26.9 14.6 9.0 6.6 6.9 20.0 20.1 7.4 16.6 7.5 6.7 21.8 5.9 5.8 14.8 7.7 26.8 19.5 15.6 7.7 6.4 19.5 16.2 45.2 7.0 8.0 15.6 10.2 7.3 21.2 18.5 7.3 19.2 12.2 20.2 23.3 21.4 18.3 15.5 15.6 12.9 16.1 16.7 17.5 10.2 26.9 11.7 14.3 9.4 17.2 17.7 6.9 18.2 15.5 23.8 20.5 12.4 15.3 15.6 18.1 19.8 15.3 12.1 15.1 18.9 12.0 14.0 9.5 26.3 19.0 17.2 23.7 16.2 17.9 23.0 23.9 12.6 31.5 12.8 22.9 12.5 19.1 20.5 17.2 18.8 21.9 8.8 19.6 16.2 21.2 16.3 17.8 18.7 14.3 12.3 15.0 19.0 22.2 10.3 9.1 13.3 0.8 1.6 1.0 12.0 2.9 10.0 2.3 15.1 9.6 1.6 2.1 15.2 11.0 0.3 1.8 3.3 3.2 16.5 5.2 6.6 6.7 8.5 8.3 6.6 6.5 6.6 6.9 6.7 6.4 7.0 7.3 8.7 0.0 4.6 14.0 4.5 7.4 7.3 3.9 6.2 7.9 8.8 9.1 4.6 2.8 6.2 11.0 10.4 8.4 5.9 6.0 3.9 7.3 30.8 6.1 7.8 7.3 9.0 8.6 9.5 8.0 11.4 6.2 4.1 6.0 1.3 8.9 5.7 8.8 5.4 13.5 11.7 4.8 6.1 3.8 4.1 10.3 7.8 4.5 7.2 10.3 2.8 4.1 6.2 11.1 8.8 11.7 4.1 10.1 3.2 11.6 4.6 3.7 3.8 10.4 19.7 7.7 7.7 26.6 24.1 6.0 9.2 6.3 7.8 7.0 7.3 5.6 MPV17 SYM1 ENSG00000115204 "Mitochondrial inner membrane protein MPV17" P39210 2 27309492-27325680 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 68: Epididymis - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "unprognostic (9.34e-3)" "unprognostic (2.70e-1)" "unprognostic (9.50e-2)" "unprognostic (2.21e-1)" "unprognostic (1.54e-1)" "unprognostic (1.89e-2)" "prognostic unfavorable (6.99e-6)" "unprognostic (1.05e-1)" "unprognostic (1.37e-1)" "unprognostic (1.56e-1)" "unprognostic (2.22e-1)" "unprognostic (1.48e-1)" "unprognostic (1.44e-3)" "unprognostic (2.59e-3)" "unprognostic (2.52e-1)" "unprognostic (5.10e-3)" "unprognostic (4.62e-2)" 50.2 86.5 56.4 37.8 58.1 31.3 39.9 59.1 58.4 36.0 59.3 32.5 25.0 37.9 47.7 32.6 37.7 36.7 78.2 56.3 59.1 48.6 22.6 39.1 43.2 58.8 57.1 43.7 33.2 70.0 38.9 35.0 58.1 34.1 34.1 26.7 35.9 35.0 18.3 32.0 27.5 57.7 56.9 37.1 29.1 15.5 60.3 46.0 51.6 30.0 48.1 44.9 28.1 63.2 74.1 68.2 49.7 42.6 202.7 237.0 46.6 70.8 143.6 67.2 60.7 55.0 52.0 41.5 72.8 97.2 124.0 61.3 64.1 134.1 69.5 56.9 63.7 79.5 58.8 105.6 125.4 47.3 48.7 229.3 116.3 118.6 169.4 94.3 100.2 49.8 77.0 77.1 113.9 107.4 46.9 71.5 55.7 106.7 69.1 64.6 73.2 85.2 149.2 58.5 33.1 107.2 37.6 43.7 82.1 49.3 49.0 60.6 88.6 67.0 68.8 83.4 76.4 108.1 106.1 130.4 109.2 105.4 76.1 59.5 93.7 42.9 59.3 81.4 64.4 84.5 60.5 67.4 120.5 73.6 58.0 67.8 7.8 76.0 81.7 87.4 81.4 92.1 56.4 58.1 59.1 58.4 56.3 59.1 58.8 57.1 58.1 56.9 60.3 63.2 36.0 25.6 29.3 10.7 26.3 17.2 32.8 69.2 33.0 20.5 49.5 52.8 48.9 18.6 46.5 33.1 8.4 51.1 26.3 8.8 64.6 43.3 27.4 17.3 32.6 35.9 16.8 21.6 18.4 24.3 60.2 37.5 12.2 17.5 42.5 28.7 28.2 9.9 116.9 8.4 22.7 15.0 59.0 28.5 24.0 34.2 35.4 33.7 40.9 8.4 38.1 38.9 28.8 13.6 15.5 20.7 12.9 35.0 31.4 32.1 17.6 87.1 36.7 12.7 0.0 30.1 30.8 15.5 21.2 33.9 18.8 59.4 22.2 41.8 17.7 30.7 MPZ "CMT1, CMT1B, CMT2I, CMT2J, HMSNIB, P0" ENSG00000158887 "Myelin protein zero" P25189 1 161304735-161309968 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Charcot-Marie-Tooth disease, Deafness, Dejerine-Sottas syndrome, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Sertoli cells: 6.6;Skeletal myocytes: 9.3" "Cancer enriched" "Detected in many" 11 "melanoma: 83.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in many" 4 "WM-115: 139.3" "Group enriched" "Detected in some" 4 "olfactory bulb: 2.9;pons and medulla: 1.3" "Region enriched" "Detected in some" 10 "spinal cord: 2142.4" HPA068925 Enhanced NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 46: Fibroblasts - ECM organization" "Cluster 17: WM-115 - Nervous system development" "Cluster 48: Smooth muscle cells - ECM organization" "HPA068925: AB_2732123" "unprognostic (6.77e-2)" "unprognostic (2.98e-1)" "unprognostic (9.27e-2)" "unprognostic (1.46e-1)" "unprognostic (3.35e-2)" "unprognostic (1.78e-1)" "unprognostic (1.49e-2)" "unprognostic (2.36e-1)" "unprognostic (2.95e-1)" "unprognostic (1.33e-1)" "unprognostic (7.88e-3)" "unprognostic (1.51e-1)" "unprognostic (6.62e-8)" "unprognostic (6.75e-2)" "unprognostic (1.24e-1)" "unprognostic (1.66e-1)" "unprognostic (8.32e-2)" 19.1 6.9 2.1 2.1 3.0 1.1 12.6 2.5 2.7 8.3 1.4 22.3 1.6 2.0 2.0 4.4 5.3 2.4 15.2 1.9 3.9 6.3 5.4 2.9 1.1 3.0 2.2 3.1 2.3 0.6 6.2 0.6 9.9 12.2 2.7 1.2 15.8 8.0 5.1 9.1 8.5 0.8 3.3 4.4 7.6 2.4 2.0 1.4 3.7 18.4 0.9 9.5 15.9 2.2 0.4 0.0 0.3 0.1 2.7 1.3 0.3 0.3 0.5 0.1 1.6 0.0 0.1 2.3 1.5 0.4 0.5 0.1 1.8 0.6 0.1 1.1 0.0 1.0 0.4 31.0 1.2 4.7 3.7 4.2 0.0 6.2 0.3 0.0 2.8 1.9 9.9 0.0 4.3 0.0 0.7 7.6 1.4 0.0 0.0 0.3 0.2 1.4 0.3 0.1 2.0 0.3 0.0 0.0 14.0 0.8 0.1 9.5 2.7 0.3 0.4 2.7 0.2 0.9 0.9 1.2 4.8 17.5 139.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.1 3.0 2.5 2.7 1.9 3.9 3.0 2.2 9.9 3.3 2.0 2.2 1.7 3.2 0.6 1.0 2.1 0.5 3.1 0.4 4.0 2.5 0.4 1.3 0.7 0.0 0.5 3.7 2.1 0.5 1.6 0.1 0.0 0.2 5.5 0.3 0.2 1.5 1.8 1.3 1.7 1.2 0.7 2.5 0.0 0.1 0.0 0.8 1.8 1.0 1.6 1.7 2.2 0.7 2.0 1.9 0.8 1.8 1.5 2.0 3.6 1.0 3.8 0.5 0.0 0.5 1.6 0.1 0.1 0.4 1.4 0.9 0.3 1.0 0.6 1.1 6.6 9.3 3.9 0.4 0.6 1.1 0.4 0.3 1.6 0.4 0.4 2.0 MPZL2 "EVA, EVA1" ENSG00000149573 "Myelin protein zero like 2" O60487 11 118253416-118264536 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Cell adhesion" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 222.5;urinary bladder: 155.9" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 332.5;Basal prostatic cells: 504.4;Basal respiratory cells: 289.1;Squamous epithelial cells: 336.4;Suprabasal keratinocytes: 467.4;Urothelial cells: 489.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "classical monocyte: 11.6;intermediate monocyte: 9.2;myeloid DC: 17.0;neutrophil: 13.2" "Group enriched" "Detected in many" 10 "dendritic cells: 17.0;granulocytes: 13.2;monocytes: 11.6" "Cell line enhanced" "Detected in some" "CAPAN-2: 120.9;EFO-21: 130.4;HaCaT: 166.9;RT4: 321.7;TIME: 351.9" "Low region specificity" "Detected in many" "Region enriched" "Detected in many" 5 "spinal cord: 38.8" HPA060740 Approved Approved "Cell Junctions" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 15: RT4 - Unknown function" "Cluster 22: Epithelial cell types - Mixed function" "Cell Junctions" "HPA060740: AB_2684352" "unprognostic (1.74e-1)" "unprognostic (6.02e-2)" "unprognostic (8.23e-2)" "unprognostic (3.28e-3)" "unprognostic (9.95e-3)" "unprognostic (1.56e-1)" "unprognostic (2.11e-3)" "unprognostic (3.58e-1)" "unprognostic (7.39e-2)" "unprognostic (5.45e-2)" "prognostic unfavorable (1.14e-4)" "unprognostic (1.91e-1)" "unprognostic (3.91e-2)" "unprognostic (3.07e-2)" "unprognostic (1.80e-1)" "prognostic favorable (1.62e-4)" "unprognostic (2.08e-2)" 28.6 4.7 2.5 11.9 2.1 0.7 19.6 2.3 4.8 56.7 5.2 31.1 17.0 16.9 38.5 222.5 46.4 33.5 7.2 2.3 2.6 26.4 23.2 47.0 2.3 3.2 3.0 3.8 13.5 27.1 10.7 1.7 3.2 48.6 30.8 0.9 58.0 69.5 4.7 38.8 11.3 14.7 3.6 4.6 37.0 0.9 3.4 18.1 30.3 1.0 52.6 155.9 120.5 2.8 65.6 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 27.0 120.9 0.3 130.4 0.0 0.6 166.9 0.0 38.9 0.0 0.2 9.5 0.1 1.7 35.8 0.0 0.0 0.4 0.0 90.2 0.0 3.0 0.0 86.8 0.8 0.0 0.2 0.0 51.3 0.2 0.2 1.6 34.2 0.1 0.0 0.0 6.4 14.9 321.7 0.1 0.0 5.8 61.4 0.0 0.5 26.1 0.7 351.9 0.1 0.2 0.0 0.1 0.1 0.2 0.2 0.1 0.0 0.0 2.3 11.6 3.0 0.1 9.2 1.3 0.0 0.6 0.4 17.0 0.0 0.8 0.9 13.2 0.4 1.4 0.3 0.2 3.8 2.5 2.1 2.3 4.8 2.3 2.6 3.2 3.0 3.2 3.6 3.4 2.8 5.9 83.3 123.3 0.0 0.2 332.5 504.4 289.1 127.5 0.0 29.0 17.4 3.4 30.0 221.1 128.8 0.0 1.7 0.5 52.0 0.0 39.4 0.0 91.6 18.8 33.6 5.3 3.6 0.0 51.1 0.2 8.2 29.6 194.0 7.0 0.0 45.3 16.5 0.8 0.0 0.0 6.3 81.4 6.4 27.0 0.3 0.0 7.8 21.4 1.9 4.9 0.0 1.0 0.0 0.0 68.2 20.8 0.0 1.2 186.3 3.3 6.9 65.2 0.0 0.0 0.3 9.2 0.2 0.7 336.4 467.4 17.8 5.4 0.0 33.4 489.7 MRE11 "ATLD, MRE11A" ENSG00000020922 "MRE11 homolog, double strand break repair nuclease" P49959 11 94415570-94493885 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Host-virus interaction, Meiosis" "Endonuclease, Exonuclease, Hydrolase, Nuclease" "Cancer-related genes, Ciliopathy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 28.9;Cytotrophoblasts: 39.2;Granulosa cells: 34.1;Syncytiotrophoblasts: 28.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002691, CAB004081" Supported Enhanced Nucleoplasm NA NA "Cluster 44: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "CAB004081: AB_2145100, HPA002691: AB_1079409" "unprognostic (5.59e-3)" "unprognostic (4.35e-2)" "unprognostic (8.55e-2)" "unprognostic (2.76e-2)" "unprognostic (9.82e-2)" "unprognostic (5.17e-2)" "prognostic unfavorable (7.14e-4)" "unprognostic (2.85e-1)" "unprognostic (1.03e-2)" "unprognostic (1.34e-1)" "unprognostic (8.66e-3)" "unprognostic (6.96e-3)" "unprognostic (1.57e-3)" "unprognostic (1.39e-1)" "unprognostic (1.77e-1)" "unprognostic (1.22e-1)" "unprognostic (8.06e-3)" 9.1 6.1 3.4 11.7 3.7 22.6 13.9 6.8 3.4 8.8 6.0 7.6 6.8 11.7 8.9 7.1 7.9 7.3 5.0 3.3 3.5 6.0 6.4 7.7 12.6 5.1 4.4 11.1 7.5 5.6 3.1 12.1 3.8 9.3 11.5 6.3 7.8 7.3 5.0 15.6 7.7 9.9 4.0 12.7 7.3 8.3 4.4 14.3 7.4 5.4 16.1 8.5 7.4 6.7 21.5 21.5 39.9 5.0 13.1 18.2 22.8 29.4 19.0 25.9 30.6 39.4 43.3 55.8 47.0 15.3 32.5 40.1 33.7 22.1 34.1 37.5 20.0 48.7 31.5 22.7 6.0 32.7 33.6 12.8 13.4 33.7 21.0 11.7 23.0 26.8 34.9 35.6 20.9 15.5 33.2 30.5 13.0 49.3 23.3 29.0 35.3 28.1 16.8 29.6 14.1 19.8 40.6 26.0 8.6 33.2 43.4 19.3 16.9 38.7 28.6 33.9 21.5 8.8 33.2 54.4 10.4 50.3 31.5 5.7 8.0 6.5 8.2 10.0 8.3 6.4 6.0 8.9 11.6 6.9 5.1 8.4 3.8 8.6 8.4 8.7 8.8 6.7 3.4 3.7 6.8 3.4 3.3 3.5 5.1 4.4 3.8 4.0 4.4 6.7 23.6 28.9 14.3 0.0 6.3 0.0 0.0 0.0 0.0 0.0 12.5 13.7 0.0 0.0 9.3 9.2 0.0 39.2 20.8 0.0 3.9 11.4 0.0 19.5 22.2 8.4 0.0 0.0 0.0 8.1 15.8 8.9 0.0 16.3 17.7 34.1 0.0 0.0 14.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.0 0.0 0.0 9.3 0.0 0.0 0.0 0.0 8.8 0.0 0.0 6.1 0.0 0.0 6.5 11.7 0.0 0.0 0.0 8.5 0.0 0.0 0.0 0.0 28.0 7.2 16.8 0.0 0.0 MSRB3 "DFNB74, DKFZp686C1178, FLJ36866" ENSG00000174099 "Methionine sulfoxide reductase B3" Q8IXL7 12 65278643-65491430 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in many" 12 "Cardiomyocytes: 2801.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "eosinophil: 41.6" "Lineage enhanced" "Detected in many" "granulocytes: 41.6" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 126.1;hTERT-RPE1: 110.6;U-937: 106.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA014432 Enhanced "Intracellular and membrane" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 32: U-937 - Innate immune response" "Cluster 43: Cardiomyocytes - Nuclear processes" "HPA014432: AB_1854146" "unprognostic (1.40e-2)" "prognostic unfavorable (3.84e-4)" "unprognostic (2.86e-3)" "unprognostic (1.94e-1)" "unprognostic (2.74e-2)" "unprognostic (1.74e-2)" "unprognostic (2.63e-2)" "unprognostic (1.23e-1)" "unprognostic (1.84e-2)" "unprognostic (5.33e-2)" "unprognostic (8.28e-2)" "unprognostic (2.10e-1)" "prognostic unfavorable (8.85e-8)" "unprognostic (3.29e-3)" "unprognostic (7.80e-2)" "unprognostic (2.08e-2)" "prognostic unfavorable (2.17e-4)" 44.9 10.7 12.9 20.9 13.6 21.2 26.3 12.5 12.8 29.5 18.8 108.0 11.9 85.8 20.1 63.0 41.4 33.2 90.8 11.9 18.3 10.1 3.8 30.6 5.7 15.9 15.2 16.9 5.8 3.2 6.8 25.2 13.8 52.7 27.8 12.5 10.8 103.0 104.0 9.7 25.6 123.9 14.6 13.6 36.2 5.8 18.2 4.1 14.5 69.2 3.9 60.9 23.7 11.8 8.8 19.2 16.4 75.9 71.6 63.0 0.5 87.0 92.9 33.2 19.8 0.7 1.0 0.0 18.3 126.1 10.5 1.9 7.7 22.1 30.0 0.2 15.9 0.0 16.7 0.9 46.6 47.1 0.3 33.4 11.9 28.1 39.0 110.6 68.2 0.1 0.3 0.3 76.8 2.9 0.0 11.0 5.4 0.2 10.4 0.2 22.0 0.5 7.5 1.0 0.4 7.9 30.0 1.8 21.9 16.8 14.1 44.5 78.9 42.3 22.8 19.5 34.2 8.0 6.7 0.2 11.5 106.7 26.9 15.0 0.6 41.6 0.2 0.9 0.1 0.1 0.1 0.1 0.2 0.3 0.2 0.2 6.8 8.3 0.4 10.8 0.1 1.4 12.9 13.6 12.5 12.8 11.9 18.3 15.9 15.2 13.8 14.6 18.2 11.8 55.3 12.8 3.4 76.7 0.8 6.4 16.4 11.4 4.0 22.7 2.2 45.3 2801.7 4.3 1.2 3.7 0.0 0.4 8.3 0.0 0.0 9.3 5.7 0.9 16.7 154.2 0.0 17.4 37.1 1.0 0.4 108.8 1.1 0.4 2.5 7.4 28.2 0.2 0.5 21.9 56.6 0.0 0.0 0.0 13.7 2.2 12.5 4.0 10.6 62.8 1.6 44.4 2.1 37.7 1.4 1.6 0.0 116.6 0.3 14.8 0.0 0.4 6.8 10.6 105.2 37.7 218.7 4.2 4.7 0.8 4.5 0.7 2.4 10.3 0.0 2.9 MT-ATP6 "ATP6, ATPase-6, MTATP6, RP, Su6m" ENSG00000198899 "Mitochondrially encoded ATP synthase membrane subunit 6" P00846 MT 8527-9207 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "ATP synthesis, Hydrogen ion transport, Ion transport, Transport" "Cardiomyopathy, Disease variant, Leber hereditary optic neuropathy, Leigh syndrome, Neuropathy, Primary mitochondrial disease, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 240231.8" "Cell type enriched" "Detected in many" 6 "Cardiomyocytes: 183462.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 15099.8" "Lineage enriched" "Detected in all" 6 "granulocytes: 15099.8" "Cell line enriched" "Detected in all" 4 "HeLa: 81002.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 39: Non-specific - Mitochondria" "Cluster 20: HeLa - Mitochondria" "Cluster 54: Cardiomyocytes - Muscle contraction" "unprognostic (2.97e-1)" "unprognostic (4.16e-1)" "unprognostic (1.86e-2)" "unprognostic (4.55e-2)" "unprognostic (8.45e-3)" "unprognostic (1.66e-1)" "prognostic favorable (3.79e-4)" "unprognostic (6.47e-2)" "unprognostic (2.39e-1)" "unprognostic (1.44e-2)" "prognostic favorable (7.64e-4)" "unprognostic (6.01e-2)" "unprognostic (4.64e-2)" "unprognostic (1.46e-1)" "unprognostic (1.37e-1)" "unprognostic (3.56e-1)" "unprognostic (2.52e-3)" 30620.5 49902.8 78564.9 5757.5 78683.9 5263.3 24700.9 71753.6 111983.3 10531.0 92461.0 34888.0 15959.6 12648.9 6224.7 18979.9 12132.1 5215.3 240231.8 73845.3 79126.1 97663.8 108393.4 13251.1 4613.5 94236.1 80705.7 11001.6 26731.7 15286.5 17490.5 7337.2 87375.8 26534.4 11997.9 12678.8 19672.9 7061.2 110786.8 21566.0 29555.6 5826.0 66562.7 15489.6 42384.5 15009.7 82151.7 2880.7 17077.7 67112.7 4344.5 21210.2 12968.0 67597.2 5618.9 8971.4 6145.8 9667.8 11469.9 2606.5 4002.9 8017.4 1465.1 1068.3 1770.2 10629.5 5953.7 9842.8 3325.6 4356.6 1640.3 11849.7 653.2 6255.4 1954.9 7091.2 5605.0 8645.7 81002.5 18778.0 1945.0 5183.5 10726.9 4289.5 5409.3 1909.8 1824.4 7406.7 1920.7 5418.1 5810.5 6963.2 4174.7 15671.4 3204.2 13620.4 1620.4 4244.5 3674.4 3985.7 2622.4 6104.2 10727.8 13879.3 3495.2 4452.8 2870.3 6024.9 6026.0 10017.9 6477.5 17539.6 10178.1 4280.9 6317.4 7166.3 5880.9 3051.9 4303.3 7137.5 3739.9 10744.5 2455.0 15099.8 2475.3 4245.7 1346.3 1650.5 1689.2 2678.1 1534.6 1712.3 1211.4 2550.5 1774.0 2220.6 2427.2 1828.9 1841.1 1470.9 1232.4 1223.2 78564.9 78683.9 71753.6 111983.3 73845.3 79126.1 94236.1 80705.7 87375.8 66562.7 82151.7 67597.2 4123.3 1487.2 1804.3 0.0 6867.9 2903.0 6184.5 4172.7 7102.6 0.0 4343.1 7054.0 183462.2 11539.8 3367.8 6422.4 0.0 0.0 6110.1 15211.0 1880.2 2059.0 908.9 7527.8 6522.7 7371.6 3995.8 17562.3 0.0 3405.9 0.0 6067.7 6569.9 13453.0 2064.3 20320.2 9969.1 26635.5 0.0 0.0 0.0 10468.7 2803.5 16148.3 2386.4 4627.8 7672.0 5539.3 2534.6 0.0 4773.4 0.0 4080.4 0.0 0.0 2818.6 9241.3 4966.1 7780.1 4657.8 24094.7 14129.0 3106.0 0.0 6304.4 11559.3 7641.7 5682.1 5225.7 5947.3 3034.9 0.0 6304.5 12298.1 10197.0 7899.3 MT-CO1 "COI, COX1, MTCO1" ENSG00000198804 "Mitochondrially encoded cytochrome c oxidase I" P00395 MT 5904-7445 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Electron transport, Respiratory chain, Transport" Translocase "Deafness, Disease variant, Leber hereditary optic neuropathy, Non-syndromic deafness, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 222644.8;heart muscle: 255389.3" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 107039.5;Hepatocytes: 59794.3;Proximal enterocytes: 98329.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HeLa: 54167.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB016241, HPA069328" Enhanced Supported Mitochondria NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 39: Non-specific - Mitochondria" "Cluster 20: HeLa - Mitochondria" "Cluster 54: Cardiomyocytes - Muscle contraction" Mitochondria "CAB016241: AB_2229888, HPA069328: AB_2686122" "unprognostic (4.39e-1)" "unprognostic (2.45e-1)" "unprognostic (1.39e-1)" "unprognostic (2.21e-1)" "unprognostic (1.59e-1)" "unprognostic (3.31e-1)" "prognostic favorable (2.29e-4)" "unprognostic (8.28e-2)" "unprognostic (1.01e-1)" "unprognostic (5.56e-3)" "unprognostic (1.20e-2)" "unprognostic (6.60e-2)" "unprognostic (2.83e-2)" "unprognostic (5.06e-3)" "unprognostic (4.50e-2)" "unprognostic (2.15e-2)" "unprognostic (2.44e-2)" 22006.8 46968.9 171347.0 8727.7 151652.8 11321.8 17952.5 132201.9 222644.8 10440.9 179120.2 42606.0 27505.7 11582.9 14226.0 20791.8 10700.5 11452.7 255389.3 151507.6 137459.2 63061.8 96575.5 12744.7 9111.4 176794.8 152802.2 8124.5 19467.4 41236.2 7420.2 10527.8 168465.9 12427.0 28389.7 12503.0 23260.1 17753.2 147209.5 26849.0 35366.3 13146.2 138626.1 16284.7 44852.9 10932.5 176888.2 7461.1 14056.3 184587.7 8381.2 17415.3 10559.7 131378.4 5837.6 8554.3 11384.1 12431.0 25510.2 11563.1 12037.2 12867.2 4284.9 3189.4 5257.4 10383.6 18320.5 15138.9 6040.7 9857.6 3118.2 21430.9 1326.6 11407.4 4515.1 7226.0 8040.6 9130.6 54167.9 19725.4 3521.2 5336.1 11055.5 13603.9 11589.8 3149.9 6917.5 14668.4 3902.1 8485.5 5916.3 10551.1 9525.6 14037.0 4378.4 23591.9 2905.0 7814.2 6900.5 5664.0 3401.6 9177.9 15910.6 15016.1 5414.7 7189.1 4466.7 17018.9 8305.7 13626.1 9809.7 17703.3 15637.8 12617.8 8438.9 12565.9 6642.1 4951.2 5072.9 3542.6 6235.7 13711.8 6294.4 5305.8 9759.2 3824.6 3085.1 4907.9 3420.5 5374.6 3047.3 3425.6 3444.6 5567.3 3080.8 3911.2 1900.4 3759.1 5775.1 4847.5 2947.7 3929.0 171347.0 151652.8 132201.9 222644.8 151507.6 137459.2 176794.8 152802.2 168465.9 138626.1 176888.2 131378.4 3924.0 2900.6 3897.1 0.0 13282.9 9769.7 9713.9 22625.0 20857.7 0.0 12033.2 11841.6 107039.5 30777.5 16135.4 19596.3 0.0 0.0 9288.4 40726.1 4255.4 7191.4 1555.3 13044.7 9033.9 7847.9 7514.7 45610.3 0.0 5089.4 0.0 6305.3 19235.7 25645.6 3832.6 20400.0 25951.4 59794.3 0.0 0.0 0.0 24302.1 19071.0 45533.4 7744.0 7398.4 11696.4 12124.7 6894.2 0.0 15180.0 0.0 8901.3 0.0 0.0 6410.5 23865.9 8490.1 13829.3 9441.3 98329.8 33652.6 10474.0 0.0 13614.6 11019.8 9403.5 12096.5 14338.7 27110.9 11475.1 0.0 11502.4 15179.6 27138.6 21770.7 MT-CO3 "CO3, COIII, COX3, MTCO3" ENSG00000198938 "Mitochondrially encoded cytochrome c oxidase III" P00414 MT 9207-9990 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" Translocase "Disease variant, Leber hereditary optic neuropathy, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 189825.4;heart muscle: 231090.6" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 98114.9;Proximal enterocytes: 47697.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HeLa: 47821.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042788 Approved NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 39: Non-specific - Mitochondria" "Cluster 20: HeLa - Mitochondria" "Cluster 54: Cardiomyocytes - Muscle contraction" "HPA042788: AB_10793985" "unprognostic (2.38e-1)" "unprognostic (5.24e-2)" "unprognostic (1.71e-1)" "unprognostic (1.88e-1)" "unprognostic (3.04e-1)" "unprognostic (2.93e-1)" "prognostic favorable (2.01e-4)" "unprognostic (1.18e-1)" "unprognostic (1.45e-2)" "unprognostic (1.05e-2)" "prognostic favorable (1.04e-4)" "unprognostic (1.05e-1)" "unprognostic (8.80e-3)" "unprognostic (2.75e-2)" "unprognostic (1.20e-1)" "unprognostic (9.29e-2)" "unprognostic (1.33e-2)" 27612.7 53681.0 106768.6 6403.7 100201.0 11914.6 26962.2 92217.9 189825.4 9972.2 122787.3 41553.8 21299.6 10118.8 12166.4 23137.6 10414.1 8134.8 231090.6 101700.1 98402.0 135745.7 93934.0 11738.0 7309.6 111323.1 103274.0 9356.4 21307.1 30833.6 18098.1 9332.4 106050.0 25270.8 25404.7 14193.4 21229.0 16620.0 98348.0 28350.1 31017.2 10682.4 91790.3 14201.4 41772.3 19009.4 106894.6 5959.0 20136.7 138793.4 9366.6 19763.5 13535.9 91700.3 6374.2 7329.2 11033.5 15732.2 21484.7 8772.8 6020.3 8032.3 4753.9 3111.6 4736.6 9884.1 9176.0 14020.9 3392.6 6719.8 3380.0 16891.6 1769.9 9653.6 5455.7 4794.4 7644.1 7478.3 47821.5 16704.0 4327.8 4505.2 9419.7 8504.4 13400.6 3422.1 5046.7 10915.4 5848.3 7900.3 6047.2 13759.0 10367.7 12916.5 4589.9 25941.9 2461.0 9979.3 5226.1 4852.9 3482.9 10181.9 19232.2 10970.2 4917.9 6797.0 3741.8 4032.3 8135.9 15244.2 8471.0 19585.6 9432.2 5152.8 8782.1 9756.5 5388.8 5622.3 3881.6 8183.5 5151.5 14362.6 3475.8 2863.0 4714.1 2004.7 1562.3 1885.5 1896.8 2933.1 1703.2 1823.0 1927.4 3253.5 2137.7 2759.1 3629.6 2089.5 1920.3 1612.4 1186.9 2432.3 106768.6 100201.0 92217.9 189825.4 101700.1 98402.0 111323.1 103274.0 106050.0 91790.3 106894.6 91700.3 2817.9 1910.3 2767.0 0.0 9010.7 8343.8 9724.5 21550.3 14394.8 0.0 8643.0 8027.7 98114.9 20354.3 11786.8 16547.0 0.0 0.0 5698.3 25285.3 4368.9 5152.0 1929.0 10274.3 6922.4 7282.3 6805.3 29321.2 0.0 6670.2 0.0 5902.5 8605.1 22503.2 2090.9 20302.5 15810.3 44494.8 0.0 0.0 0.0 19209.5 11157.0 28166.3 5603.1 9286.2 11579.8 7637.7 5553.1 0.0 9746.7 0.0 6001.1 0.0 0.0 5901.3 16542.9 7809.0 8204.1 6813.7 47697.3 33390.3 6427.3 0.0 12142.0 15068.6 7967.9 11927.7 12469.2 17772.8 8480.1 0.0 7584.6 21335.3 22667.3 15127.4 MT-CYB "COB, CYTB, MTCYB, UQCR3" ENSG00000198727 "Mitochondrially encoded cytochrome b" P00156 MT 14747-15887 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Electron transport, Respiratory chain, Transport" "Cardiomyopathy, Cataract, Deafness, Disease variant, Leber hereditary optic neuropathy, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 130283.4" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 87067.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "ASC diff: 14365.7;HeLa: 18945.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032215, HPA068400, HPA074796" Approved Supported Mitochondria NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 39: Non-specific - Mitochondria" "Cluster 20: HeLa - Mitochondria" "Cluster 54: Cardiomyocytes - Muscle contraction" Mitochondria "CAB032215: AB_2261378, HPA068400: AB_2685982, HPA074796: " "unprognostic (4.50e-1)" "unprognostic (2.56e-1)" "unprognostic (9.12e-2)" "unprognostic (3.88e-2)" "unprognostic (9.22e-2)" "unprognostic (3.50e-1)" "prognostic favorable (5.96e-4)" "unprognostic (1.63e-2)" "unprognostic (8.53e-2)" "unprognostic (1.49e-2)" "unprognostic (1.01e-3)" "unprognostic (6.09e-2)" "unprognostic (1.40e-1)" "unprognostic (7.90e-3)" "unprognostic (3.07e-1)" "unprognostic (4.09e-2)" "unprognostic (1.54e-2)" 17885.7 25075.8 39972.4 2636.6 41108.8 2926.5 15122.5 36592.4 54341.4 6621.5 47885.4 19364.4 8941.2 7119.4 6555.4 10592.2 7498.6 3433.7 130283.4 39044.7 39534.1 60620.7 59133.6 6549.1 2529.8 46506.6 40032.7 6068.7 15418.7 9106.2 11552.0 5320.4 42841.1 15142.5 8793.2 8513.5 12205.1 7331.2 52625.7 13392.0 17520.7 5804.8 34579.6 7362.7 25263.2 7372.2 41908.6 1737.2 9758.2 63751.5 3582.0 12844.4 7620.0 35340.5 2322.4 3039.1 3687.6 3950.3 14365.7 2287.8 2963.8 2587.3 1076.5 668.0 1136.3 3013.8 4943.2 5840.7 1240.7 3087.3 794.6 7063.3 556.2 3180.7 1613.0 2880.4 2458.9 3277.0 18945.0 5461.7 2697.8 1862.5 3828.3 4981.3 4631.2 1257.6 2679.7 4457.1 1715.5 2341.4 1709.0 3565.6 3417.2 6354.8 1735.3 3789.4 824.1 2230.7 2036.7 2028.2 1449.8 3681.4 5134.1 5275.9 1308.0 2302.7 1802.1 3352.1 2587.4 5497.2 4911.1 6332.5 5398.3 2302.7 2984.2 4256.3 2037.2 972.6 1390.1 2557.4 1385.7 2822.6 1485.0 8811.6 3750.4 4806.7 1834.1 1738.1 2355.1 2806.2 2123.9 2376.2 1485.5 3034.9 2241.0 2781.9 2755.9 1680.5 1944.8 1468.0 1511.0 1612.6 39972.4 41108.8 36592.4 54341.4 39044.7 39534.1 46506.6 40032.7 42841.1 34579.6 41908.6 35340.5 3091.7 1185.9 1390.0 0.0 5710.5 3319.9 7605.2 9945.0 8512.3 0.0 4026.8 5510.1 87067.0 11564.1 5338.9 7470.6 0.0 0.0 3723.1 10971.1 2163.9 2555.0 789.7 9063.7 5550.2 5673.6 2863.2 16130.5 0.0 3523.1 0.0 4692.6 4895.1 15794.2 1889.0 16261.2 9871.2 17132.6 0.0 0.0 0.0 9502.4 5486.9 14290.0 2254.1 3983.1 7943.2 4269.6 2612.9 0.0 4118.1 0.0 2612.8 0.0 0.0 2977.1 8823.6 5402.0 5725.9 4425.8 25108.7 14736.3 4210.2 0.0 5798.2 9579.6 5914.9 4807.6 4136.3 9142.3 3422.9 0.0 5502.2 11093.2 10319.6 9796.7 MT-ND1 "MTND1, NAD1, ND1" ENSG00000198888 "Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1" P03886 MT 3307-4262 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Electron transport, Respiratory chain, Transport" Translocase "Alzheimer disease, Amyloidosis, Diabetes mellitus, Disease variant, Epilepsy, FDA approved drug targets, Leber hereditary optic neuropathy, MELAS syndrome, Neurodegeneration, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 111350.7;heart muscle: 127951.9" "Cell type enriched" "Detected in many" 5 "Cardiomyocytes: 101184.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 9432.2" "Lineage enriched" "Detected in all" 7 "granulocytes: 9432.2" "Cell line enhanced" "Detected in all" "HeLa: 28480.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033779, HPA066847" Approved NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 39: Non-specific - Mitochondria" "Cluster 20: HeLa - Mitochondria" "Cluster 54: Cardiomyocytes - Muscle contraction" "CAB033779: AB_2149736, HPA066847: " "prognostic favorable (3.63e-4)" "unprognostic (3.55e-1)" "unprognostic (3.77e-2)" "unprognostic (3.65e-1)" "unprognostic (3.50e-1)" "unprognostic (1.28e-1)" "unprognostic (1.95e-3)" "unprognostic (5.84e-2)" "unprognostic (1.06e-1)" "unprognostic (5.05e-2)" "prognostic favorable (3.26e-4)" "unprognostic (8.67e-2)" "unprognostic (8.66e-2)" "unprognostic (3.24e-2)" "unprognostic (1.42e-2)" "unprognostic (3.99e-2)" "unprognostic (2.85e-2)" 19099.4 24937.1 77977.0 2682.9 79000.3 3456.4 17901.1 73833.1 111350.7 4652.6 82243.3 19464.4 6416.3 5929.7 6428.9 8365.1 6119.1 2846.9 127951.9 74131.5 81543.6 47946.3 45024.8 7877.3 2245.9 84675.5 84925.4 4636.3 15523.0 12519.5 7993.9 5163.4 88069.3 11358.6 8792.2 6455.8 11429.4 7047.3 69102.4 14504.0 16935.3 3849.2 68588.4 8228.4 26033.5 12223.4 81883.1 2158.8 7231.1 61460.4 2986.2 10333.3 5443.7 72626.3 3533.6 3499.2 2812.3 2571.1 10434.4 1879.8 3604.8 2946.1 872.8 805.7 835.0 6132.0 3710.1 4259.8 1831.7 2239.3 810.9 2285.7 316.3 1774.7 1592.0 3064.7 2432.6 4755.7 28480.4 8841.6 2231.9 2279.1 4495.2 4494.5 4734.4 1241.1 1773.2 3240.7 877.2 1226.5 2235.4 2580.5 2400.4 4813.7 1841.1 9325.6 757.8 2191.3 2603.6 1916.7 1277.6 2295.7 4312.3 5574.2 1165.0 1844.2 1632.5 2572.1 2943.6 3403.7 2306.2 7771.2 4632.1 2652.3 2396.0 3427.2 2511.3 2841.3 1883.7 2015.4 1784.6 3937.3 744.7 9432.2 1265.2 2347.3 512.4 662.6 732.0 1155.4 614.6 683.5 439.9 1185.3 800.8 960.2 3270.7 759.6 733.2 677.2 480.0 507.7 77977.0 79000.3 73833.1 111350.7 74131.5 81543.6 84675.5 84925.4 88069.3 68588.4 81883.1 72626.3 1754.9 1352.6 1511.3 0.0 3159.5 2265.8 3355.3 1632.2 2928.1 0.0 3174.3 3513.1 101184.9 9771.1 1985.3 4610.8 0.0 0.0 2175.7 12456.8 1033.1 1511.9 1087.5 3160.1 1985.1 4881.6 3135.6 8308.9 0.0 3595.1 0.0 2970.8 2347.6 5039.6 1402.2 7165.4 7745.2 16276.4 0.0 0.0 0.0 10835.1 927.7 12435.2 1651.4 5233.2 7049.5 2982.5 1497.7 0.0 4450.1 0.0 2385.2 0.0 0.0 2180.4 8080.9 3546.9 2046.0 3735.0 18353.7 8183.6 1760.8 0.0 6409.6 6534.6 4075.7 4806.0 5071.3 2061.1 2073.2 0.0 2839.0 4329.0 10735.4 5236.0 MT-ND2 "MTND2, NAD2, ND2" ENSG00000198763 "Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2" P03891 MT 4470-5511 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Electron transport, Respiratory chain, Transport" Translocase "Alzheimer disease, Amyloidosis, Disease variant, Leber hereditary optic neuropathy, Leigh syndrome, Neurodegeneration, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 101525.8;heart muscle: 130517.4" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 77734.8;Proximal enterocytes: 33797.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 6 "basophil: 16754.8" "Lineage enriched" "Detected in all" 10 "granulocytes: 16754.8" "Cell line enhanced" "Detected in all" "HeLa: 23544.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 39: Non-specific - Mitochondria" "Cluster 20: HeLa - Mitochondria" "Cluster 54: Cardiomyocytes - Muscle contraction" "unprognostic (5.82e-3)" "unprognostic (1.58e-2)" "unprognostic (1.53e-2)" "unprognostic (1.36e-1)" "unprognostic (4.77e-1)" "unprognostic (4.79e-2)" "unprognostic (9.56e-3)" "unprognostic (3.74e-2)" "unprognostic (2.18e-1)" "unprognostic (3.38e-3)" "unprognostic (4.55e-3)" "unprognostic (3.79e-2)" "unprognostic (4.35e-2)" "unprognostic (3.94e-2)" "unprognostic (2.11e-1)" "unprognostic (5.92e-2)" "unprognostic (4.35e-2)" 25741.8 33190.5 71860.8 2728.1 75185.8 2871.9 21730.1 67030.8 101525.8 7501.8 71811.2 22574.5 7339.4 7298.5 8093.3 11090.4 9270.8 2863.6 130517.4 67583.8 74656.1 57055.4 53965.1 9461.4 2469.7 81497.3 77858.3 7800.1 20642.6 9848.0 12388.5 5446.8 84069.6 17166.0 8141.9 5436.2 13468.5 5444.8 45903.7 15500.0 20333.4 3554.4 65578.7 8952.9 31183.1 11451.9 75256.7 2049.2 10704.5 50400.1 2830.9 14131.4 8428.2 66998.7 2964.9 3166.9 2774.5 4699.2 9795.6 1730.7 2618.5 2678.9 669.9 703.1 875.8 4014.2 3860.6 4185.9 2486.9 1936.7 1150.4 5147.5 444.4 3349.6 1504.2 3675.8 2270.9 4845.1 23544.1 6585.1 1999.7 4760.9 5392.4 2886.1 5969.8 1726.7 1692.0 2488.5 1049.4 2269.3 3606.2 3978.3 1701.5 3480.4 2711.2 7603.4 1396.2 3068.2 2045.4 2352.3 1554.8 3525.9 5071.4 4465.8 1728.4 2059.3 1159.0 3501.0 4372.7 4402.7 5412.1 5417.8 3333.0 2606.6 3230.5 3719.5 3483.2 2577.9 2356.8 3637.4 1695.0 4006.5 1196.1 16754.8 1658.1 2709.0 872.0 1066.1 1373.3 1568.7 1012.2 1099.7 632.5 1625.8 1212.2 1558.3 2355.9 1158.8 1341.7 1171.9 716.1 804.2 71860.8 75185.8 67030.8 101525.8 67583.8 74656.1 81497.3 77858.3 84069.6 65578.7 75256.7 66998.7 1855.6 919.9 759.8 0.0 3886.7 2666.7 7962.2 3116.2 2155.8 0.0 2560.5 3948.5 77734.8 10211.5 2425.9 6232.9 0.0 0.0 2313.0 13115.0 1807.8 1793.7 1314.5 4100.0 2322.6 4025.7 3175.3 10585.1 0.0 3677.8 0.0 2629.4 2366.5 5225.2 1865.9 7033.2 9394.0 19067.5 0.0 0.0 0.0 10974.6 1947.0 14566.9 1814.8 6327.6 9064.4 3148.2 1657.8 0.0 4768.9 0.0 3602.5 0.0 0.0 2565.3 9271.1 4538.8 1959.6 4228.6 33797.5 12714.8 3449.0 0.0 7283.9 6341.5 3547.2 5465.6 4872.6 1826.5 2455.7 0.0 3694.7 2538.3 10272.4 7385.5 MT-ND4 "LHON, MTND4, NAD4, ND4" ENSG00000198886 "Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4" P03905 MT 10760-12137 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Electron transport, Respiratory chain, Transport" Translocase "Disease variant, Dystonia, Leber hereditary optic neuropathy, MELAS syndrome, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 196536.0" "Cell type enriched" "Detected in many" 7 "Cardiomyocytes: 253563.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 13456.8" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HeLa: 41594.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA053928 Approved Supported Mitochondria NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 39: Non-specific - Mitochondria" "Cluster 20: HeLa - Mitochondria" "Cluster 54: Cardiomyocytes - Muscle contraction" Mitochondria "HPA053928: AB_2682313" "unprognostic (8.39e-2)" "unprognostic (1.83e-1)" "unprognostic (7.29e-2)" "unprognostic (9.54e-2)" "unprognostic (5.41e-2)" "unprognostic (3.78e-2)" "unprognostic (2.50e-3)" "unprognostic (8.16e-2)" "unprognostic (1.45e-1)" "prognostic favorable (1.76e-4)" "unprognostic (1.01e-2)" "unprognostic (7.23e-2)" "unprognostic (2.79e-2)" "unprognostic (1.53e-1)" "unprognostic (1.43e-1)" "unprognostic (3.14e-2)" "unprognostic (4.24e-2)" 23701.9 43566.1 86386.5 4193.8 83474.8 3652.7 19363.5 76852.9 119139.4 8711.6 100909.6 30312.4 11021.5 10764.3 6795.9 15885.7 10624.6 4622.9 196536.0 81116.7 85290.4 76204.1 101401.1 11855.8 3820.4 102081.7 90689.2 8957.6 21476.2 15709.9 12834.3 7692.4 97098.9 22214.5 15007.9 14112.1 17508.5 11691.2 61489.1 18268.8 25046.6 7116.7 75024.9 12782.7 39594.1 13571.1 91494.4 3233.7 14785.3 70605.7 4913.1 19417.4 10309.3 74806.7 4251.7 4285.9 5449.6 8075.1 12523.6 3123.1 3808.6 4184.0 1603.2 958.4 1834.2 6555.4 4688.4 7428.4 3608.7 3590.8 1396.3 7685.0 496.1 6777.9 1691.7 4330.2 2654.6 4592.7 41594.9 11166.3 1884.9 4672.8 5223.9 5330.2 7007.6 1403.3 4977.9 8925.4 2344.4 3683.1 3908.9 8930.2 3461.9 9508.0 1848.1 10481.0 1551.2 3650.3 2876.4 2481.0 1712.1 4518.2 6770.1 8938.3 1999.0 2694.8 2434.3 7967.3 4267.8 9600.3 5601.2 10888.7 6532.2 3851.7 3726.9 5232.7 3330.8 5307.6 2292.6 3407.7 2514.1 7881.4 2100.8 13456.8 3334.1 7103.1 1902.0 2192.8 2614.3 3555.5 2129.5 2285.7 1616.0 3624.4 2452.9 3095.1 2513.1 2106.5 2329.2 2112.6 1668.2 1840.0 86386.5 83474.8 76852.9 119139.4 81116.7 85290.4 102081.7 90689.2 97098.9 75024.9 91494.4 74806.7 3065.0 1269.2 1516.1 0.0 6183.3 4404.5 9073.3 7719.8 2713.0 0.0 6210.4 6965.6 253563.4 15377.3 4975.3 12806.1 0.0 0.0 4005.7 20185.0 2435.8 2924.2 1109.7 6731.7 4298.6 9316.2 5090.0 20898.0 0.0 4058.3 0.0 5843.3 5601.5 11920.4 2188.6 15486.9 13931.3 35046.7 0.0 0.0 0.0 14557.8 5771.7 22254.8 3452.7 5132.5 8834.9 4749.3 3799.3 0.0 6280.7 0.0 4212.2 0.0 0.0 3710.0 12363.2 5788.3 3409.4 5872.9 28978.7 17714.1 4527.9 0.0 6310.9 8264.3 7732.9 6461.4 6003.0 3008.8 4937.6 0.0 5125.3 7671.5 15595.2 11405.7 MT-ND4L "MTND4L, NAD4L, ND4L" ENSG00000212907 "Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L" P03901 MT 10470-10766 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Electron transport, Respiratory chain, Transport" Translocase "Disease variant, Leber hereditary optic neuropathy, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 132930.7;heart muscle: 145078.7" "Cell type enriched" "Detected in many" 5 "Cardiomyocytes: 30444.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HeLa: 50775.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA075648 Approved Centrosome,Mitochondria NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 39: Non-specific - Mitochondria" "Cluster 20: HeLa - Mitochondria" "Cluster 54: Cardiomyocytes - Muscle contraction" Mitochondria Centrosome "HPA075648: AB_2686760" "unprognostic (5.81e-2)" "unprognostic (3.46e-2)" "unprognostic (2.76e-2)" "unprognostic (7.91e-2)" "unprognostic (5.64e-2)" "unprognostic (1.05e-1)" "prognostic favorable (4.47e-4)" "unprognostic (1.97e-1)" "unprognostic (4.04e-2)" "unprognostic (4.63e-3)" "unprognostic (6.61e-2)" "unprognostic (7.38e-3)" "unprognostic (1.39e-1)" "unprognostic (3.09e-1)" "unprognostic (3.73e-1)" "unprognostic (2.97e-2)" "unprognostic (5.68e-2)" 20104.7 29874.0 85794.9 4122.5 86270.4 3115.3 14930.3 82985.5 132930.7 6880.0 93989.2 20616.6 9025.8 7679.7 5976.7 10820.3 7752.4 4365.8 145078.7 84214.9 90415.7 46912.7 74928.5 8462.2 2787.1 92948.1 87984.2 6729.2 16038.2 20410.6 9234.3 5840.3 89012.2 16438.2 14044.5 15747.5 12913.6 12715.8 58998.5 13345.9 17015.9 6979.3 79192.1 7285.6 28192.3 9561.4 87700.1 4435.4 11270.7 103082.4 4852.1 15113.7 7437.4 83632.8 4598.0 4121.5 7308.1 7468.2 25088.0 5217.1 3223.3 9523.0 2384.3 1468.4 2651.9 6894.3 4080.7 11229.9 3809.7 6497.0 2387.4 8496.5 1155.8 10210.3 2895.1 4454.2 4711.8 8095.9 50775.4 13024.1 3671.8 8429.4 6965.0 9229.0 10159.4 2792.9 9675.2 10923.1 2983.6 5697.7 4556.7 7771.2 5412.1 8124.5 3199.8 10639.4 1846.3 4811.8 4953.4 1842.5 3155.8 5025.1 7636.0 9464.9 2208.4 2971.3 4666.2 7283.7 3197.8 15599.0 5199.9 10420.1 9592.2 3792.1 4708.5 5630.1 3738.0 6985.1 3552.9 6053.5 2725.1 11018.8 1816.1 16170.2 4327.0 8286.8 2536.0 2849.6 3435.6 4233.2 2723.9 2939.9 2282.7 4618.7 3206.8 4006.1 2010.3 2906.4 2817.9 2884.1 2096.4 2551.4 85794.9 86270.4 82985.5 132930.7 84214.9 90415.7 92948.1 87984.2 89012.2 79192.1 87700.1 83632.8 503.6 224.4 217.6 0.0 2303.6 228.5 254.2 170.4 5991.6 0.0 764.0 886.3 30444.3 1464.1 438.4 323.7 0.0 0.0 449.8 1428.3 90.1 152.9 52.8 870.1 618.8 942.3 256.6 3302.0 0.0 342.2 0.0 1129.2 5335.9 1186.3 479.3 1394.0 1520.3 4413.7 0.0 0.0 0.0 727.8 99.7 1977.9 193.5 286.1 417.2 1043.8 256.1 0.0 312.9 0.0 133.9 0.0 0.0 284.5 867.0 230.9 4395.8 129.7 1228.2 589.4 582.7 0.0 348.4 711.2 1052.8 247.0 207.4 5256.4 242.2 0.0 1387.0 308.6 573.4 207.9 MT-ND5 "MTND5, NAD5, ND5" ENSG00000198786 "Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5" P03915 MT 12337-14148 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Electron transport, Respiratory chain, Transport" Translocase "Disease variant, Leber hereditary optic neuropathy, Leigh syndrome, MELAS syndrome, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 25147.7;heart muscle: 26116.9;skeletal muscle: 25697.4" "Cell type enriched" "Detected in many" 5 "Cardiomyocytes: 35040.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HeLa: 10198.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 39: Non-specific - Mitochondria" "Cluster 20: HeLa - Mitochondria" "Cluster 54: Cardiomyocytes - Muscle contraction" "unprognostic (2.87e-1)" "unprognostic (3.18e-2)" "unprognostic (3.00e-1)" "unprognostic (1.53e-1)" "unprognostic (2.99e-1)" "unprognostic (1.30e-1)" "unprognostic (1.07e-3)" "unprognostic (5.09e-3)" "unprognostic (1.06e-2)" "unprognostic (3.01e-1)" "unprognostic (3.29e-3)" "unprognostic (4.78e-2)" "prognostic favorable (7.31e-5)" "unprognostic (9.93e-3)" "unprognostic (8.75e-2)" "unprognostic (1.26e-2)" "unprognostic (3.68e-2)" 5288.6 4777.7 18907.8 1742.2 18307.4 1525.5 2456.7 14400.2 21432.3 1614.3 22368.1 4280.6 4135.2 1972.7 2508.1 2717.8 3030.2 2040.5 26116.9 16370.1 20521.2 8014.5 10041.3 2683.6 1180.6 25147.7 20794.2 1886.3 2631.6 4813.1 1528.8 1691.5 23065.0 2812.7 2879.0 3264.8 2819.2 2163.8 25697.4 6657.3 4780.7 2643.7 13881.7 2014.4 6673.9 1678.5 21024.6 794.7 2059.1 19444.2 1541.4 3557.5 1537.7 13870.1 1615.8 1671.5 1998.7 1937.9 5903.9 1530.3 1075.8 3208.3 492.5 355.1 583.1 2472.6 2051.0 3865.3 1590.5 1510.4 397.3 3350.6 191.2 1685.7 583.4 2182.3 1281.4 2840.4 10198.2 4239.2 678.8 2010.7 2824.3 2305.4 1315.5 401.6 951.8 1933.5 725.2 1233.3 1056.8 1794.8 1216.3 3046.1 757.3 2453.4 397.5 910.2 903.0 1432.9 938.2 1668.7 2083.2 3132.2 595.0 904.1 1496.1 2636.3 894.4 3001.9 1927.1 2979.2 5094.9 2013.2 1403.2 2409.7 1271.9 678.8 1246.0 1066.9 1077.4 1780.4 897.7 2851.8 1521.7 874.2 771.4 980.3 922.8 979.1 753.9 839.2 746.5 1096.6 729.2 869.0 446.2 785.1 1039.5 890.3 628.6 492.0 18907.8 18307.4 14400.2 21432.3 16370.1 20521.2 25147.7 20794.2 23065.0 13881.7 21024.6 13870.1 773.3 628.2 594.2 0.0 1707.9 895.1 1050.1 1005.5 3261.6 0.0 1003.4 1025.1 35040.8 2566.4 934.5 1156.8 0.0 0.0 977.0 3181.2 283.7 804.1 109.5 3130.4 2025.6 1614.3 782.9 3776.6 0.0 936.6 0.0 1437.2 3609.6 5212.8 862.1 2987.5 2623.3 6597.7 0.0 0.0 0.0 1776.8 583.9 3664.2 661.9 528.9 1057.5 1364.5 608.3 0.0 1303.9 0.0 756.0 0.0 0.0 1327.8 2211.7 848.6 2674.2 753.3 4484.5 2410.8 1282.0 0.0 696.8 1941.5 1558.6 652.2 521.9 3002.4 973.6 0.0 1527.8 1560.9 1650.5 1506.6 MT-ND6 "MTND6, NAD6, ND6" ENSG00000198695 "Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6" P03923 MT 14149-14673 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Electron transport, Respiratory chain, Transport" Translocase "Disease variant, Dystonia, Leber hereditary optic neuropathy, Leigh syndrome, MELAS syndrome, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 35802.7;skeletal muscle: 57879.2" "Cell type enriched" "Detected in many" 13 "Cardiomyocytes: 15756.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HeLa: 20826.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 39: Non-specific - Mitochondria" "Cluster 20: HeLa - Mitochondria" "Cluster 54: Cardiomyocytes - Muscle contraction" "unprognostic (1.96e-1)" "unprognostic (3.27e-1)" "unprognostic (2.28e-1)" "unprognostic (1.13e-1)" "unprognostic (2.21e-1)" "unprognostic (1.22e-2)" "unprognostic (1.03e-3)" "unprognostic (6.02e-3)" "unprognostic (1.68e-2)" "unprognostic (1.48e-1)" "unprognostic (6.06e-3)" "unprognostic (2.91e-1)" "prognostic favorable (8.91e-6)" "unprognostic (3.64e-2)" "unprognostic (1.42e-2)" "unprognostic (1.15e-2)" "unprognostic (2.92e-2)" 7945.8 6310.2 5769.7 3186.7 3927.7 3253.0 3096.2 2199.5 5682.5 2191.3 13970.3 6452.8 7840.8 3145.2 54.5 5822.6 5447.4 3433.9 35802.7 4361.1 7820.0 9569.5 11697.0 4598.5 2503.1 13167.2 11029.3 2126.9 4152.4 69.3 1372.8 953.0 13713.7 2509.5 97.7 4313.6 4084.0 40.6 57879.2 15225.1 8006.6 51.8 1229.7 4205.8 10030.4 1993.1 8318.4 40.9 2562.5 243.6 43.1 5236.3 1897.2 1060.7 3305.7 2595.3 2255.7 2869.4 371.0 34.6 1614.6 4329.1 8.9 13.9 14.2 3553.8 3233.4 6999.5 2873.3 117.5 423.7 4781.1 25.1 79.1 23.3 4178.5 1966.3 4217.6 20826.9 10361.0 29.7 2704.1 3805.1 64.4 103.3 103.9 86.4 2123.1 23.2 1445.3 1855.2 2671.0 94.5 6976.5 836.0 3680.9 492.5 1868.7 1267.3 2002.7 1440.3 3034.3 60.9 9493.6 926.2 1476.3 2250.2 3898.6 1876.3 3559.0 3037.2 5182.3 8822.6 2473.6 2088.6 3550.5 1766.8 906.6 2600.9 1705.0 1682.9 2680.8 1473.8 2089.0 1092.3 645.1 733.4 881.5 840.2 1047.3 776.1 800.0 582.8 1016.1 760.2 870.6 453.3 752.2 963.0 790.6 635.2 365.4 5769.7 3927.7 2199.5 5682.5 4361.1 7820.0 13167.2 11029.3 13713.7 1229.7 8318.4 1060.7 31.2 83.3 62.2 0.0 328.4 16.8 55.8 75.1 1210.0 0.0 52.2 31.2 15756.5 273.1 107.1 128.8 0.0 0.0 78.9 125.6 17.6 32.6 8.2 154.1 132.5 478.6 30.1 797.7 0.0 35.3 0.0 396.2 886.9 247.7 98.0 130.6 385.8 699.5 0.0 0.0 0.0 59.8 44.7 518.3 20.1 33.4 62.4 214.3 33.8 0.0 66.3 0.0 48.4 0.0 0.0 25.6 69.9 45.1 1055.4 152.0 76.1 175.7 111.0 0.0 59.2 121.6 423.9 31.7 60.5 1160.0 20.5 0.0 266.3 58.1 78.4 117.0 MTMR2 "CMT4B, KIAA1073" ENSG00000087053 "Myotubularin related protein 2" Q13614 11 95821766-95925315 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Lipid metabolism" Hydrolase "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 120.1;Oligodendrocytes: 226.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049831 Approved Supported Vesicles NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 77: Retina - Visual perception" "Cluster 15: RT4 - Unknown function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Vesicles "HPA049831: AB_2680904" "unprognostic (1.71e-2)" "unprognostic (2.55e-3)" "unprognostic (7.81e-3)" "unprognostic (4.16e-1)" "unprognostic (4.18e-3)" "unprognostic (5.36e-2)" "prognostic unfavorable (1.61e-8)" "unprognostic (3.23e-3)" "unprognostic (3.42e-2)" "unprognostic (1.77e-2)" "prognostic unfavorable (3.60e-4)" "unprognostic (1.12e-1)" "unprognostic (2.34e-2)" "unprognostic (1.54e-1)" "unprognostic (1.50e-1)" "unprognostic (1.14e-1)" "unprognostic (8.03e-3)" 14.7 9.3 11.0 11.2 16.8 4.4 11.8 16.3 18.3 12.2 12.2 12.9 7.1 12.3 6.2 14.7 12.4 14.3 13.5 10.8 14.3 16.4 4.3 12.3 9.5 15.1 14.4 11.5 7.8 12.7 6.4 24.5 15.8 16.1 13.9 18.6 20.5 11.4 6.2 8.2 8.3 18.0 13.5 8.6 13.0 31.0 14.1 15.1 9.9 8.9 12.1 15.2 10.4 22.4 24.1 25.3 54.1 39.2 19.2 29.0 47.5 43.3 37.9 42.4 37.8 57.3 47.1 16.2 50.3 45.5 35.9 30.9 47.7 48.2 38.9 30.8 21.3 31.5 55.0 33.0 42.8 59.3 26.7 24.0 31.2 56.6 54.5 41.8 64.4 35.4 44.7 14.2 39.6 17.9 29.0 27.2 46.6 59.0 34.9 23.2 32.2 16.8 43.9 125.0 35.6 40.6 43.6 36.4 19.2 35.1 27.6 26.5 64.4 47.7 45.1 34.4 41.1 13.1 42.4 14.3 20.4 15.6 50.6 9.8 3.9 1.7 12.4 4.7 13.4 5.8 7.9 15.7 7.6 4.9 4.0 11.3 0.9 14.1 7.2 3.7 8.1 7.8 11.0 16.8 16.3 18.3 10.8 14.3 15.1 14.4 15.8 13.5 14.1 22.4 19.6 3.2 8.6 28.7 9.6 10.3 15.0 9.0 8.6 0.0 8.0 6.7 17.3 0.0 11.6 9.2 0.0 9.0 8.8 9.1 9.8 17.8 74.8 18.1 14.1 20.2 16.2 12.8 69.8 16.9 34.3 17.0 9.7 8.7 19.0 49.1 11.0 1.0 12.5 0.0 37.5 9.8 24.4 10.3 8.2 120.1 11.1 8.3 3.6 40.3 6.8 0.0 14.4 63.8 226.6 17.7 4.7 12.0 7.0 15.1 6.0 29.3 17.0 0.0 32.9 7.9 29.0 46.8 19.2 15.4 6.0 9.0 8.8 12.9 10.6 15.6 MUSK ENSG00000030304 "Muscle associated receptor tyrosine kinase" O15146 9 110668779-110806558 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Differentiation "Developmental protein, Kinase, Muscle protein, Receptor, Transferase, Tyrosine-protein kinase" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 6.2;skeletal muscle: 4.1" "Cell type enhanced" "Detected in some" "Late spermatids: 4.8;Leydig cells: 5.3;Oligodendrocytes: 17.0;Peritubular cells: 19.5;Skeletal myocytes: 23.1" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 16 "LHCN-M2: 24.7;RH-30: 23.7" "Region enhanced" "Detected in some" "basal ganglia: 5.0" "Not detected" "Not detected" NA NA "Cluster 70: Brain - Nervous system development" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 50: Fibroblasts - ECM organization" "unprognostic (6.12e-2)" "unprognostic (9.01e-2)" "unprognostic (5.39e-2)" "unprognostic (3.66e-1)" "unprognostic (3.14e-1)" "unprognostic (1.20e-2)" "unprognostic (1.50e-2)" "unprognostic (2.46e-1)" "unprognostic (3.13e-1)" "unprognostic (7.58e-2)" "unprognostic (6.03e-5)" "unprognostic (4.58e-2)" "unprognostic (1.62e-1)" "unprognostic (9.67e-2)" "unprognostic (5.11e-2)" 0.1 0.2 1.5 1.7 3.0 0.0 0.0 0.8 1.5 0.0 1.6 1.9 1.1 0.0 0.0 1.4 0.0 1.1 1.5 1.2 1.1 0.0 0.3 1.0 0.6 2.7 6.2 0.1 0.1 0.0 0.0 0.3 1.7 0.2 2.5 0.0 0.1 0.0 4.1 0.1 2.4 0.5 2.9 0.0 1.3 1.6 2.0 0.1 0.0 2.0 2.0 1.2 0.0 4.9 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.4 0.0 0.0 1.5 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 24.7 0.0 0.0 0.0 0.5 0.0 0.2 0.0 23.7 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 3.0 0.8 1.5 1.2 1.1 2.7 6.2 1.7 2.9 2.0 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 3.5 0.0 0.3 0.1 0.0 0.0 1.3 0.0 0.0 4.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 4.8 5.3 0.0 0.0 1.9 0.0 0.0 0.0 2.5 17.0 0.0 0.0 19.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 23.1 0.1 0.5 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 MYH14 "DFNA4, FLJ13881, KIAA2034, MHC16, MYH17" ENSG00000105357 "Myosin heavy chain 14" Q7Z406 19 50188186-50310542 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cell shape" "Actin-binding, Calmodulin-binding, Motor protein, Myosin" "Deafness, Disease variant, Neuropathy, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 191.3" "Cell type enhanced" "Detected in many" "Distal enterocytes: 487.2;Paneth cells: 306.4;Proximal enterocytes: 376.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 48.6;CAPAN-2: 59.4;HaCaT: 119.0;MCF7: 59.0;OE19: 61.7;RT4: 147.8;SK-BR-3: 51.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA062391, HPA067889, HPA070260" Enhanced Approved Nucleoplasm NA NA 9600000 "Cluster 80: Striated muscle - Unknown function" "Cluster 15: RT4 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "HPA062391: AB_2684748, HPA067889: AB_2685917, HPA070260: AB_2686243" "unprognostic (2.52e-1)" "unprognostic (5.81e-2)" "unprognostic (9.63e-2)" "unprognostic (3.73e-3)" "unprognostic (1.44e-1)" "unprognostic (1.40e-1)" "unprognostic (1.39e-1)" "unprognostic (1.79e-1)" "unprognostic (1.71e-1)" "unprognostic (3.48e-2)" "unprognostic (1.93e-2)" "unprognostic (1.01e-1)" "prognostic favorable (3.97e-8)" "prognostic favorable (7.83e-4)" "unprognostic (8.50e-2)" "unprognostic (3.12e-1)" "unprognostic (2.77e-1)" 12.6 1.0 24.1 7.0 35.0 0.0 8.8 38.2 23.3 13.3 22.0 64.5 83.8 1.5 0.2 63.7 15.4 3.6 41.3 20.0 30.9 10.2 25.4 24.4 0.1 38.7 35.6 0.4 17.3 16.7 18.5 0.4 35.7 8.8 19.5 5.1 44.0 5.7 191.3 87.7 76.7 1.3 29.5 0.1 45.5 2.6 34.4 1.5 33.2 35.1 6.1 11.0 31.8 37.4 48.6 5.0 0.0 25.0 0.0 0.0 7.2 0.0 0.0 0.0 0.0 33.1 59.4 0.2 30.1 0.0 3.7 119.0 0.1 0.0 0.0 0.1 8.7 0.0 0.0 25.7 0.0 0.0 17.3 0.0 0.3 0.0 0.0 0.0 0.0 0.0 3.4 0.2 0.0 59.0 0.0 0.3 0.8 61.7 0.7 0.1 29.4 0.7 0.0 147.8 0.1 0.2 2.9 51.8 0.0 0.2 9.7 1.9 0.0 0.1 11.7 0.2 0.1 0.9 11.2 0.3 0.3 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 24.1 35.0 38.2 23.3 20.0 30.9 38.7 35.6 35.7 29.5 34.4 37.4 0.1 80.1 36.5 23.5 2.8 3.3 18.7 29.3 0.0 3.7 17.9 9.3 21.8 44.3 50.9 57.0 2.1 0.1 0.3 487.2 0.0 53.2 0.9 58.1 6.0 1.2 51.6 0.0 10.9 27.2 0.1 1.1 85.1 70.7 14.7 0.0 2.9 45.8 0.1 16.8 21.7 109.4 22.4 0.8 1.6 0.8 0.3 1.3 5.4 2.8 0.0 19.7 0.0 23.6 27.5 67.5 306.4 0.0 0.3 30.8 376.1 7.6 80.6 11.5 0.0 17.7 3.5 0.5 4.6 30.8 21.0 0.0 2.0 0.0 122.8 86.2 MYH9 "DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHCA" ENSG00000100345 "Myosin heavy chain 9" P35579 22 36281280-36387967 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cell adhesion, Cell shape" "Actin-binding, Calmodulin-binding, Motor protein, Myosin" "Alport syndrome, Cancer-related genes, Cataract, Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "TIME: 1343.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001644, CAB015386, HPA064783" Enhanced Supported "Nuclear bodies,Plasma membrane,Actin filaments,Cytosol" No No 410000000 "Cluster 41: Basophils - Cellular respiration" "Cluster 82: Adipose tissue - ECM organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 1: Pancreatic cells - Digestion" "Plasma membrane, Actin filaments" "Nuclear bodies, Cytosol" "CAB015386: AB_784698, HPA001644: AB_1079439, HPA064783: AB_2732721" "unprognostic (1.38e-1)" "unprognostic (9.12e-2)" "unprognostic (4.21e-2)" "unprognostic (6.34e-2)" "unprognostic (1.49e-1)" "unprognostic (3.90e-2)" "unprognostic (9.56e-2)" "unprognostic (8.28e-2)" "unprognostic (5.50e-2)" "unprognostic (6.38e-2)" "unprognostic (1.93e-2)" "unprognostic (1.61e-1)" "unprognostic (7.98e-2)" "unprognostic (9.48e-2)" "unprognostic (1.64e-1)" "unprognostic (1.62e-1)" "unprognostic (2.59e-2)" 295.9 95.5 42.3 181.1 42.1 245.9 231.5 40.6 54.7 181.2 65.5 192.6 107.0 356.4 39.3 153.8 182.2 134.5 161.1 50.8 39.4 140.7 101.6 286.2 161.7 52.7 51.7 121.1 160.3 55.0 52.6 166.5 48.1 131.8 89.8 9.7 177.2 98.4 84.0 160.6 163.5 174.1 48.8 232.5 135.8 38.2 52.1 125.1 141.2 46.3 104.1 168.8 166.8 48.2 612.2 277.0 86.2 74.2 156.8 195.1 437.3 398.4 507.5 554.6 413.2 302.1 170.3 156.9 230.1 666.1 265.0 412.7 125.2 779.4 559.6 356.1 120.9 302.6 294.3 259.9 481.1 346.9 463.8 233.0 234.7 751.9 626.4 540.3 461.8 113.2 67.3 205.8 448.9 161.9 124.4 204.0 51.7 171.1 169.2 233.3 267.3 146.7 314.5 581.5 129.6 53.0 559.7 217.0 251.6 218.5 162.4 177.1 1343.7 1222.6 370.3 237.5 731.5 135.2 114.7 129.0 463.2 172.3 363.1 72.6 25.2 64.7 32.4 19.8 28.4 13.4 23.5 26.4 17.2 11.9 18.3 20.4 41.2 9.0 26.5 8.0 26.3 54.5 42.3 42.1 40.6 54.7 50.8 39.4 52.7 51.7 48.1 48.8 52.1 48.2 303.9 118.6 87.1 12.7 108.4 144.0 182.4 123.1 72.8 2.6 90.5 89.4 62.6 80.1 89.7 92.0 2.1 87.0 151.7 359.8 7.9 309.4 35.8 89.7 121.6 258.7 73.8 51.9 42.5 245.8 193.1 82.9 123.8 194.7 93.1 117.1 132.8 102.8 100.4 82.4 6.7 131.0 59.0 119.6 124.2 37.4 68.0 168.8 85.4 61.8 196.6 11.9 137.0 7.5 33.3 344.6 186.8 211.4 125.9 184.4 159.8 27.5 51.5 5.3 203.8 39.9 275.2 6.9 10.4 133.6 135.1 46.4 213.2 141.3 139.5 134.3 MYO15A "DFNB3, MYO15" ENSG00000091536 "Myosin XVA" Q9UKN7 17 18108706-18179802 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" Hearing "Actin-binding, Calmodulin-binding, Motor protein, Myosin" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 9 "pituitary gland: 62.9" "Group enriched" "Detected in many" 4 "Early spermatids: 69.9;Late spermatids: 53.6" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 4 "basophil: 1.4" "Lineage enriched" "Detected in single" 5 "granulocytes: 1.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA078501 Enhanced NA NA "Cluster 34: Basophils - Unknown function" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 29: Early spermatids - Spermatogenesis" "HPA078501: AB_2732383" "unprognostic (2.48e-3)" "unprognostic (5.31e-2)" "unprognostic (2.87e-3)" "unprognostic (7.35e-3)" "unprognostic (4.92e-3)" "unprognostic (2.33e-1)" "unprognostic (8.32e-4)" "unprognostic (4.51e-2)" "unprognostic (1.51e-1)" "unprognostic (1.24e-1)" "unprognostic (4.66e-3)" "unprognostic (8.38e-2)" "unprognostic (4.18e-3)" "unprognostic (5.69e-3)" "unprognostic (9.89e-2)" "unprognostic (1.47e-1)" "unprognostic (2.21e-2)" 0.5 0.4 0.5 0.3 0.4 0.1 0.6 0.5 1.5 1.3 0.0 0.7 0.3 1.0 1.5 0.3 1.4 0.2 0.6 0.0 0.6 0.6 1.9 0.9 0.1 1.8 0.5 2.2 0.5 0.8 62.9 0.1 2.1 0.9 0.3 0.3 0.6 0.9 0.4 0.3 0.6 0.2 0.5 0.5 0.6 7.2 1.4 0.8 0.9 0.0 0.2 0.7 0.8 0.4 0.0 0.0 0.4 0.0 0.2 0.7 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.2 0.0 0.0 0.0 0.2 0.0 0.3 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.5 0.0 0.1 0.1 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.1 1.4 0.1 0.1 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.5 0.4 0.5 1.5 0.0 0.6 1.8 0.5 2.1 0.5 1.4 0.4 0.3 0.0 1.1 0.7 0.8 1.5 2.1 0.2 1.2 2.9 0.9 0.6 4.0 1.5 0.1 0.0 0.0 0.5 0.3 0.7 0.0 0.8 69.9 0.8 0.9 1.0 4.2 0.0 8.5 0.9 0.3 1.4 0.5 1.2 6.3 1.3 0.4 1.7 0.6 10.1 4.5 0.5 0.0 0.8 1.4 53.6 1.2 0.8 3.6 1.0 1.3 2.6 2.1 1.5 0.9 0.6 0.1 1.2 0.1 1.9 0.4 0.3 0.2 2.5 0.0 4.6 1.1 9.2 13.4 0.4 1.3 0.7 0.6 0.7 0.8 1.0 MYO3A DFNB30 ENSG00000095777 "Myosin IIIA" Q8NEV4 10 25934229-26212532 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hearing, Sensory transduction, Vision" "Actin-binding, Kinase, Motor protein, Myosin, Serine/threonine-protein kinase, Transferase" "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "retina: 15.5;testis: 5.2" "Cell type enhanced" "Detected in some" "Early spermatids: 156.6;Late spermatids: 58.2;Muller glia cells: 74.8;Spermatocytes: 31.7" "Cancer enhanced" "Detected in many" "cervical cancer: 1.7" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 1.3;CAPAN-2: 1.2;HEK 293: 1.5;SCLC-21H: 1.4;U-2 OS: 2.4;U-698: 6.3" "Not detected" "Not detected" "HPA051893, HPA075413" Enhanced Supported "Plasma membrane,Actin filaments,Cytoplasmic bodies" No No "Cluster 77: Retina - Visual perception" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 5: Muller glia cells - Visual perception" "Actin filaments, Cytoplasmic bodies" "Plasma membrane" "HPA051893: , HPA075413: " "unprognostic (5.00e-3)" "unprognostic (3.36e-2)" "unprognostic (1.53e-1)" "unprognostic (3.20e-3)" "unprognostic (2.96e-1)" "unprognostic (4.37e-2)" "unprognostic (5.29e-2)" "unprognostic (2.74e-1)" "unprognostic (4.31e-2)" "unprognostic (1.03e-1)" "unprognostic (5.66e-3)" "unprognostic (7.96e-3)" "unprognostic (6.34e-2)" "unprognostic (1.46e-2)" "unprognostic (6.62e-2)" "unprognostic (9.69e-2)" 0.1 0.1 0.4 0.0 1.8 0.1 0.1 0.0 0.8 0.1 0.2 0.1 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.1 0.6 0.3 0.0 0.1 0.0 0.6 0.5 0.0 0.7 0.0 0.5 0.0 0.5 0.1 0.3 15.5 0.0 0.1 0.0 0.7 0.1 0.0 0.2 0.0 0.2 5.2 0.3 0.2 0.2 0.1 0.2 0.0 0.3 0.3 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.9 0.8 0.0 0.0 0.7 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 6.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 1.8 0.0 0.8 0.1 0.6 0.6 0.5 0.5 0.2 0.3 0.3 0.2 0.0 0.5 2.0 0.1 1.8 0.3 0.0 0.0 0.9 0.6 0.3 0.6 0.0 2.5 0.0 0.0 0.0 0.0 0.2 1.9 0.8 156.6 0.6 0.1 0.3 1.8 0.0 2.2 0.0 0.4 0.6 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 5.9 0.4 0.0 0.0 0.0 58.2 1.2 0.1 0.0 1.9 0.0 74.8 0.0 1.0 0.4 0.2 0.0 1.2 0.0 0.3 0.0 1.0 0.0 3.9 0.0 0.0 2.4 31.7 14.2 2.4 1.0 0.0 0.0 0.0 0.4 0.3 MYO6 "DFNA22, DFNB37, KIAA0389" ENSG00000196586 "Myosin VI" Q9UM54 6 75749192-75919537 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Endocytosis, Hearing, Protein transport, Transport" "Actin-binding, Calmodulin-binding, Motor protein, Myosin" "Cardiomyopathy, Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Oligodendrocytes: 409.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "gdT-cell: 5.5;MAIT T-cell: 3.0;memory CD4 T-cell: 1.8;memory CD8 T-cell: 3.1;naive CD8 T-cell: 3.0;NK-cell: 2.9" "Group enriched" "Detected in many" 7 "NK-cells: 2.9;T-cells: 5.5" "Cell line enhanced" "Detected in many" "RT4: 103.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010762, HPA035482, HPA035483" Enhanced Supported Nucleoplasm NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 15: RT4 - Unknown function" "Cluster 22: Epithelial cell types - Mixed function" Nucleoplasm "CAB010762: AB_477166, HPA035482: , HPA035483: AB_2674647" "unprognostic (6.29e-2)" "unprognostic (6.34e-2)" "unprognostic (3.63e-3)" "unprognostic (1.30e-1)" "unprognostic (8.98e-2)" "unprognostic (2.73e-2)" "unprognostic (3.41e-3)" "unprognostic (1.23e-2)" "unprognostic (1.23e-2)" "unprognostic (2.66e-2)" "unprognostic (7.78e-2)" "unprognostic (2.78e-2)" "prognostic favorable (1.27e-12)" "unprognostic (1.57e-1)" "unprognostic (1.72e-1)" "unprognostic (1.41e-1)" "unprognostic (2.49e-2)" 9.9 9.5 18.6 7.1 29.3 0.3 28.3 22.6 32.0 18.5 32.6 22.1 33.0 7.6 22.9 32.0 11.5 27.0 5.3 19.6 19.5 51.4 15.2 23.2 4.7 23.7 24.4 4.7 21.6 40.4 14.5 7.6 24.3 17.2 19.2 49.0 25.9 19.9 3.4 16.8 33.9 5.7 16.0 7.6 27.6 14.6 23.9 5.1 15.9 3.1 12.8 24.0 15.8 34.6 52.2 13.0 12.3 8.9 29.7 23.7 42.6 20.7 23.6 12.3 18.3 22.2 44.2 0.1 16.1 25.7 14.0 40.0 15.3 29.2 18.6 17.0 30.3 17.4 5.6 14.1 25.0 0.0 22.2 17.5 21.6 19.3 14.5 24.0 43.3 7.9 22.4 7.2 15.4 48.3 0.2 0.8 7.7 44.1 3.8 0.7 29.1 1.6 51.1 103.6 26.8 14.8 5.6 46.6 6.8 28.3 16.5 35.8 59.4 13.7 9.3 0.6 20.0 13.2 16.1 0.3 10.9 0.2 5.3 0.2 0.1 0.1 5.5 0.0 3.0 0.2 1.8 3.1 0.0 0.1 0.4 3.0 0.6 2.9 0.1 0.1 0.2 0.8 18.6 29.3 22.6 32.0 19.6 19.5 23.7 24.4 24.3 16.0 23.9 34.6 74.8 141.1 207.0 286.3 4.7 30.1 87.5 49.2 18.2 83.6 99.6 35.9 8.1 38.6 91.3 150.8 120.9 32.0 14.7 112.2 54.8 128.9 7.0 86.9 26.9 57.2 85.0 0.0 147.8 120.3 23.8 30.5 91.7 169.2 26.0 81.0 37.9 33.8 6.3 95.9 167.2 76.4 116.0 2.9 6.1 9.6 30.1 6.7 30.2 105.9 2.7 307.3 12.3 179.4 409.1 197.0 99.7 43.2 11.4 165.9 105.7 97.6 109.5 188.4 13.1 26.5 32.7 14.4 32.1 28.3 34.1 78.4 13.4 191.8 77.5 199.7 MYO7A "DFNA11, DFNB2, NSRD2, USH1B" ENSG00000137474 "Myosin VIIA" Q13402 11 77128246-77215241 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Hearing "Actin-binding, Calmodulin-binding, Motor protein, Myosin" "Deafness, Disease variant, Leber congenital amaurosis, Non-syndromic deafness, Retinitis pigmentosa, Usher syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 41.9;choroid plexus: 53.2" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 47.9;Cytotrophoblasts: 42.3;Hofbauer cells: 30.1;Kupffer cells: 17.8;Rod photoreceptor cells: 31.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "classical monocyte: 2.6;intermediate monocyte: 1.7" "Lineage enhanced" "Detected in single" "monocytes: 2.6" "Cell line enhanced" "Detected in some" "BEWO: 11.8;CACO-2: 9.0;RH-30: 19.5;RPMI-8226: 13.8;SK-BR-3: 10.5;U-937: 18.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" CAB034059 Uncertain NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 77: Retina - Visual perception" "Cluster 32: U-937 - Innate immune response" "Cluster 47: Cytotrophoblasts - Unknown function" "CAB034059: AB_2148626" "unprognostic (1.14e-3)" "unprognostic (2.58e-2)" "unprognostic (2.94e-2)" "unprognostic (1.61e-1)" "unprognostic (9.66e-2)" "unprognostic (4.02e-3)" "unprognostic (1.55e-1)" "unprognostic (1.14e-1)" "unprognostic (1.19e-1)" "unprognostic (1.32e-1)" "unprognostic (3.65e-2)" "unprognostic (6.81e-2)" "prognostic unfavorable (3.07e-4)" "unprognostic (1.31e-1)" "unprognostic (1.14e-1)" "unprognostic (1.10e-2)" "unprognostic (3.03e-2)" 5.2 41.9 2.5 3.0 2.9 1.0 3.1 2.2 2.7 1.9 53.2 2.8 2.2 1.5 1.2 1.0 2.7 2.8 2.5 4.0 8.6 4.3 23.3 2.3 2.9 5.0 8.3 5.2 5.4 0.5 19.1 16.0 8.4 2.4 1.2 27.4 1.5 0.8 1.4 0.8 2.8 2.2 3.5 15.8 2.2 24.5 5.1 1.4 2.0 0.7 1.1 2.0 1.6 4.4 0.0 1.3 0.2 0.0 0.0 0.0 11.8 0.0 0.0 0.0 0.0 9.0 2.0 0.0 2.0 0.0 0.1 0.3 0.0 0.1 0.0 0.0 1.7 0.0 0.3 5.7 0.2 0.4 0.0 0.1 0.0 0.0 0.5 0.0 3.9 0.0 0.2 0.0 0.0 1.2 0.0 0.0 0.6 1.2 0.3 0.0 19.5 13.8 0.0 0.3 2.9 0.9 0.1 10.5 0.1 2.2 1.3 1.3 0.4 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 18.9 0.0 0.0 2.6 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.7 0.1 0.0 0.0 0.8 2.5 2.9 2.2 2.7 4.0 8.6 5.0 8.3 8.4 3.5 5.1 4.4 1.7 0.0 0.0 0.0 0.2 0.3 0.3 0.0 0.0 14.2 0.5 0.5 4.4 4.3 0.0 0.0 47.9 42.3 0.3 0.2 0.0 0.6 1.9 0.1 0.5 2.2 1.2 0.0 0.7 1.7 10.5 1.4 5.6 0.3 0.0 0.8 16.4 16.1 30.1 0.0 0.8 0.7 0.0 17.8 0.9 6.4 3.1 7.3 0.0 6.5 0.8 17.0 0.0 3.0 0.1 0.7 0.2 0.4 0.1 0.1 1.7 2.7 0.1 31.4 0.0 5.2 0.3 0.4 0.6 0.1 0.3 16.1 1.4 3.2 0.6 0.2 MYO9A "FLJ11061, FLJ13244, MGC71859" ENSG00000066933 "Myosin IXA" B2RTY4 15 71822291-72118577 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Actin-binding, GTPase activation, Motor protein, Myosin" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "retina: 61.7" "Cell type enhanced" "Detected in all" "Excitatory neurons: 225.5;Inhibitory neurons: 192.9;Rod photoreceptor cells: 462.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Daudi: 43.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039812, HPA040071" Approved Approved "Plasma membrane" NA NA "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 46: Photoreceptor cells - Phototransduction" "Plasma membrane" "HPA039812: AB_10961421, HPA040071: AB_10961117" "unprognostic (7.53e-2)" "unprognostic (2.40e-1)" "unprognostic (1.96e-1)" "unprognostic (2.42e-3)" "unprognostic (1.63e-1)" "unprognostic (8.69e-3)" "unprognostic (3.77e-2)" "unprognostic (3.56e-2)" "unprognostic (1.26e-1)" "unprognostic (5.50e-2)" "unprognostic (1.32e-1)" "unprognostic (1.34e-1)" "prognostic favorable (2.14e-4)" "unprognostic (3.44e-1)" "unprognostic (4.41e-1)" "unprognostic (1.25e-1)" "unprognostic (4.23e-2)" 6.5 3.9 11.3 4.8 14.9 4.8 10.7 14.3 13.3 8.7 2.5 7.1 2.1 9.9 7.4 7.7 7.2 5.2 6.7 12.8 9.2 13.7 3.7 8.8 6.4 8.7 8.0 12.1 3.3 7.4 4.7 7.6 9.2 8.0 6.3 61.7 4.5 7.5 8.1 8.7 4.6 10.2 6.7 7.3 5.2 28.7 9.5 6.7 13.2 14.9 6.4 6.5 6.1 13.5 9.7 14.6 9.6 6.8 14.2 16.5 5.7 9.1 9.8 9.0 9.1 7.1 6.6 43.3 5.4 17.9 11.8 9.0 19.2 10.3 11.9 9.5 11.1 11.1 8.9 3.2 9.0 11.2 8.5 9.5 10.2 10.6 15.2 7.6 11.5 7.7 7.2 10.3 12.2 6.0 6.4 4.5 5.2 3.5 5.9 4.6 18.2 4.3 10.9 14.3 5.4 5.9 12.0 10.0 9.5 11.6 8.0 5.3 15.5 18.0 8.7 29.7 10.4 6.5 17.3 11.3 10.8 9.2 8.1 1.7 1.5 3.7 3.6 1.4 4.9 3.1 3.5 3.0 1.6 4.0 3.6 3.4 0.2 2.8 2.6 6.3 3.1 0.9 11.3 14.9 14.3 13.3 12.8 9.2 8.7 8.0 9.2 6.7 9.5 13.5 37.0 115.4 77.4 145.6 18.4 20.9 22.2 12.4 20.5 56.3 26.2 25.0 35.5 5.7 24.1 29.5 54.2 11.9 30.2 21.1 17.6 6.1 131.8 27.9 47.3 29.6 12.6 19.6 225.5 8.0 11.3 35.6 15.8 41.2 10.1 53.1 22.1 5.7 9.0 53.8 192.9 9.7 8.2 54.8 10.0 161.9 38.8 17.7 23.2 113.4 13.0 24.0 14.4 177.0 180.2 10.9 15.5 42.9 12.2 25.0 10.4 14.1 28.3 462.1 19.7 54.9 32.6 115.2 41.8 18.4 23.9 12.0 18.5 17.0 12.8 15.7 MYOC "GLC1A, JOAG1, TIGR" ENSG00000034971 Myocilin Q99972 1 171635417-171652688 "Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Disease variant, Glaucoma" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "tongue: 110.8" "Cell type enriched" "Detected in some" 6 "Fibroblasts: 244.4" "Cancer enriched" "Detected in many" 6 "melanoma: 13.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected" "Not detected" HPA027364 Uncertain "Secreted to extracellular matrix" NA NA 25000000 "Cluster 13: Striated muscle - Muscle contraction" "Cluster 50: Fibroblasts - ECM organization" "HPA027364: AB_10602036" "unprognostic (2.02e-2)" "unprognostic (4.65e-2)" "unprognostic (4.44e-2)" "unprognostic (6.29e-2)" "unprognostic (1.43e-1)" "unprognostic (2.33e-2)" "unprognostic (3.42e-2)" "unprognostic (3.02e-2)" "unprognostic (2.82e-2)" "unprognostic (2.54e-1)" "unprognostic (1.94e-4)" "unprognostic (5.35e-2)" "unprognostic (1.87e-1)" "unprognostic (3.87e-2)" "unprognostic (1.24e-1)" 47.1 1.1 0.0 0.0 0.0 0.0 19.2 0.2 0.0 1.8 0.0 13.0 3.5 16.5 4.9 19.6 15.3 1.5 18.3 0.0 0.1 0.2 0.1 7.4 0.1 0.5 0.1 1.3 3.0 0.1 0.2 0.2 0.2 5.3 3.5 0.0 14.0 6.4 33.8 4.7 4.8 2.9 0.0 0.0 50.2 1.4 0.1 14.1 28.7 110.8 0.2 22.6 9.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.5 0.1 0.2 0.0 0.1 0.1 12.7 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.1 0.5 0.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.9 0.3 0.1 3.1 0.0 0.0 0.1 0.0 0.0 244.4 11.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 3.1 1.0 8.7 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 37.6 2.4 0.1 0.0 0.0 0.0 0.0 0.0 15.1 6.3 0.1 0.1 1.1 0.0 0.0 1.1 0.2 0.0 0.0 MYORG "KIAA1161, NET37" ENSG00000164976 "Myogenesis regulating glycosidase (putative)" Q6NSJ0 9 34366666-34376898 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Glycosidase, Hydrolase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 84.2" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 9.6;Cytotrophoblasts: 55.5;Exocrine glandular cells: 11.8;Pancreatic endocrine cells: 10.3;Proximal tubular cells: 9.2;Syncytiotrophoblasts: 17.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "Hep G2: 35.4;SK-BR-3: 56.8;T-47d: 52.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA060533, HPA067487" Enhanced Approved Mitochondria NA NA "Cluster 20: T-cells - T-cell receptor" "Cluster 80: Striated muscle - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 47: Cytotrophoblasts - Unknown function" Mitochondria "HPA060533: AB_2684311, HPA067487: AB_2685848" "unprognostic (6.56e-2)" "unprognostic (1.51e-1)" "unprognostic (3.03e-2)" "prognostic unfavorable (6.96e-4)" "unprognostic (2.44e-1)" "unprognostic (1.20e-1)" "unprognostic (2.44e-1)" "unprognostic (2.03e-2)" "unprognostic (1.55e-1)" "unprognostic (4.68e-3)" "unprognostic (1.91e-3)" "unprognostic (3.20e-1)" "prognostic favorable (1.20e-13)" "unprognostic (4.08e-3)" "unprognostic (3.68e-1)" "unprognostic (3.09e-1)" "unprognostic (1.00e-3)" 8.1 6.2 30.6 3.4 30.3 2.0 3.4 27.1 31.5 1.7 16.8 19.0 27.3 2.7 1.9 5.3 4.5 6.1 3.9 28.4 28.2 14.5 41.5 3.2 1.5 34.0 33.5 1.0 11.1 1.5 5.5 19.8 28.7 3.2 16.2 3.4 5.6 5.2 84.2 3.7 25.8 4.4 24.5 1.4 15.0 1.3 31.8 1.1 1.9 39.2 1.8 3.1 2.4 24.2 8.1 5.5 9.2 5.6 3.8 1.2 19.7 1.4 1.1 0.8 1.3 13.9 8.3 4.4 15.9 1.4 4.0 16.4 6.7 15.5 1.1 1.4 3.6 0.8 24.6 35.4 0.5 0.8 2.7 1.8 7.2 2.6 3.0 4.3 3.8 3.3 1.1 4.2 2.0 13.4 2.5 1.2 5.5 27.4 4.4 4.0 4.6 1.3 4.9 2.9 1.3 13.0 10.8 56.8 0.9 7.8 52.8 1.3 3.2 1.8 11.0 1.6 3.5 2.8 6.5 1.6 1.6 3.1 1.6 0.4 0.1 0.2 0.7 0.1 0.5 0.2 0.4 0.4 0.0 0.2 0.2 0.3 0.3 0.4 0.1 0.1 0.6 0.1 30.6 30.3 27.1 31.5 28.4 28.2 34.0 33.5 28.7 24.5 31.8 24.2 3.9 9.6 1.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 3.0 2.7 0.0 0.0 2.5 3.7 0.0 55.5 0.3 0.0 1.9 5.7 0.0 3.4 0.7 2.1 0.0 0.0 0.0 11.8 3.6 1.1 0.0 2.0 1.3 0.2 0.0 0.0 4.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.6 0.0 0.0 0.0 0.0 10.3 0.0 0.0 0.0 0.0 0.0 9.2 2.2 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 17.4 0.3 0.1 0.0 0.0 MYRF "C11orf9, MRF, Ndt80, pqn-47" ENSG00000124920 "Myelin regulatory factor" Q9Y2G1 11 61752636-61788518 "Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins, Transcription factors" "Differentiation, Transcription, Transcription regulation" "Activator, DNA-binding, Hydrolase, Protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 168.0;stomach 1: 88.3" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 48.1;Cholangiocytes: 60.1;Gastric mucus-secreting cells: 130.0;Oligodendrocytes: 255.8;Pancreatic endocrine cells: 70.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 38.8;CACO-2: 63.6;CAPAN-2: 34.0;EFO-21: 48.6;Hep G2: 21.8;OE19: 37.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA018310 Approved Nucleoplasm,Cytosol NA NA 1400000 "Cluster 70: Brain - Nervous system development" "Cluster 39: CACO-2 - Unknown function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm Cytosol "HPA018310: AB_1845534" "unprognostic (3.51e-2)" "unprognostic (3.34e-1)" "unprognostic (1.56e-1)" "unprognostic (5.39e-2)" "unprognostic (1.54e-1)" "unprognostic (3.65e-2)" "unprognostic (1.34e-1)" "unprognostic (9.34e-3)" "unprognostic (2.44e-1)" "unprognostic (1.27e-1)" "unprognostic (1.01e-2)" "unprognostic (2.54e-2)" "prognostic unfavorable (2.01e-4)" "unprognostic (8.91e-3)" "unprognostic (1.11e-1)" "unprognostic (2.67e-1)" "unprognostic (6.73e-2)" 15.4 0.6 31.3 1.1 99.0 0.3 0.4 67.9 67.5 2.2 0.0 3.8 11.4 13.1 0.1 2.4 15.4 17.3 2.4 36.9 48.8 12.0 16.9 22.3 0.1 101.7 89.4 17.6 31.6 0.0 0.4 1.1 84.9 0.7 1.1 0.4 0.6 0.3 0.1 0.5 10.8 1.9 43.5 0.5 88.3 3.1 85.7 0.0 0.3 0.0 0.1 0.5 0.6 168.0 3.1 38.8 4.7 1.5 0.0 0.0 0.2 0.2 0.1 0.9 0.8 63.6 34.0 0.9 48.6 0.0 1.2 0.3 1.3 0.0 0.9 0.1 0.6 0.2 0.7 21.8 18.9 0.0 0.4 0.3 0.0 0.6 0.0 10.9 0.1 1.6 11.7 0.3 0.2 0.5 0.0 0.9 1.6 37.2 4.8 0.0 0.1 1.9 6.5 0.0 0.1 0.9 0.0 0.4 0.3 10.6 0.6 0.4 1.4 0.4 19.5 0.0 0.6 0.2 0.1 0.3 0.1 2.0 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 31.3 99.0 67.9 67.5 36.9 48.8 101.7 89.4 84.9 43.5 85.7 168.0 0.1 48.1 5.1 2.3 0.6 0.1 0.1 0.2 0.0 0.5 0.8 0.8 1.3 60.1 3.4 3.7 0.0 0.4 1.6 6.4 0.0 31.7 0.2 1.4 3.2 0.6 1.2 0.0 0.9 36.7 0.3 5.6 130.0 4.1 0.0 4.4 0.7 6.0 0.9 0.0 1.1 4.5 6.1 0.0 0.6 1.2 5.9 0.8 3.6 0.0 1.0 3.5 0.0 5.5 255.8 70.5 13.0 3.8 0.4 0.2 12.8 2.2 1.3 0.3 0.0 0.2 1.2 1.4 3.7 0.8 0.0 0.8 0.7 0.3 7.7 3.1 NARS2 "DFNB94, FLJ23441, SLM5" ENSG00000137513 "Asparaginyl-tRNA synthetase 2, mitochondrial" Q96I59 11 78435968-78574874 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Protein biosynthesis" "Aminoacyl-tRNA synthetase, Ligase" "Deafness, Disease variant, Leigh syndrome, Non-syndromic deafness, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026793 Supported Approved Nucleoplasm,Mitochondria,Cytosol No No "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 59: Non-specific - Transcription" "Nucleoplasm, Mitochondria" Cytosol "HPA026793: AB_1848833" "unprognostic (1.80e-1)" "unprognostic (1.95e-1)" "unprognostic (5.73e-3)" "unprognostic (1.79e-3)" "unprognostic (1.40e-2)" "unprognostic (2.05e-1)" "unprognostic (1.28e-1)" "unprognostic (5.62e-2)" "unprognostic (4.62e-3)" "prognostic favorable (1.39e-5)" "unprognostic (1.96e-1)" "unprognostic (1.56e-1)" "prognostic favorable (1.22e-6)" "unprognostic (8.57e-2)" "unprognostic (1.45e-1)" "unprognostic (2.93e-1)" "unprognostic (1.60e-1)" 7.3 11.9 10.7 6.8 12.3 6.2 11.1 12.4 13.3 9.6 19.8 11.3 10.3 9.1 11.2 8.1 9.9 7.0 11.7 10.4 11.7 19.0 23.5 7.6 9.6 11.7 13.9 11.4 10.6 11.4 7.6 8.0 13.1 10.8 10.9 13.4 10.7 7.3 23.5 7.2 9.7 7.4 11.3 7.4 9.9 7.5 11.4 11.7 11.5 19.6 9.7 8.7 8.1 12.3 16.7 22.8 23.5 15.4 16.1 13.5 19.5 13.5 13.1 20.6 16.9 39.4 17.4 40.9 34.1 8.7 19.8 21.5 39.9 26.3 28.3 27.0 21.3 28.9 17.3 33.7 13.3 31.3 10.1 9.4 16.8 18.1 32.0 18.3 17.9 33.7 44.5 11.0 23.1 19.4 32.7 50.3 25.6 67.3 27.3 33.6 38.2 55.5 27.2 23.0 27.8 17.5 20.1 25.4 35.5 25.1 24.1 12.3 10.9 27.7 32.8 32.0 23.1 18.1 33.1 91.1 5.4 27.7 19.2 9.5 9.3 4.4 11.1 10.4 13.8 17.6 12.8 12.5 16.6 15.0 18.5 16.7 2.0 20.3 12.8 12.7 10.5 10.3 10.7 12.3 12.4 13.3 10.4 11.7 11.7 13.9 13.1 11.3 11.4 12.3 5.8 19.2 26.4 27.7 14.5 13.5 14.2 12.0 12.5 5.2 9.4 6.5 8.8 5.7 10.3 5.5 2.1 20.0 4.4 4.0 29.4 9.5 13.1 10.1 7.4 6.6 12.0 9.2 34.7 7.3 23.6 9.0 10.2 9.0 8.2 14.0 2.5 19.8 12.4 0.0 45.1 8.3 22.4 6.3 11.6 5.4 7.8 6.3 17.8 45.0 2.9 6.3 4.1 42.7 47.7 7.5 9.9 4.9 14.6 17.5 7.0 28.9 10.2 9.0 6.6 7.5 8.8 8.6 19.5 12.0 13.8 15.3 7.8 9.0 14.6 10.7 NAXD "CARKD, FLJ10769, LP3298" ENSG00000213995 "NAD(P)HX dehydratase" Q8IW45 13 110615545-110639996 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" Lyase "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 34.8;Distal tubular cells: 39.2;Extravillous trophoblasts: 26.7;Granulosa cells: 27.6;Syncytiotrophoblasts: 30.9;Theca cells: 24.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA010551 Approved NA NA 390000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 35: Non-specific - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 7: Non-specific - Mitochondria" "HPA010551: AB_1848669" "unprognostic (1.24e-1)" "unprognostic (5.14e-2)" "unprognostic (1.79e-2)" "prognostic favorable (3.15e-4)" "unprognostic (1.78e-1)" "unprognostic (1.81e-1)" "unprognostic (3.48e-2)" "unprognostic (2.89e-1)" "unprognostic (3.20e-1)" "unprognostic (9.01e-2)" "unprognostic (1.94e-2)" "unprognostic (4.36e-3)" "prognostic favorable (4.63e-5)" "unprognostic (2.19e-2)" "unprognostic (1.27e-1)" "unprognostic (2.30e-1)" "unprognostic (1.62e-2)" 17.3 37.1 44.0 16.0 43.7 8.2 19.4 43.6 46.3 16.7 40.8 23.1 22.9 18.7 26.6 23.4 22.6 21.3 26.4 45.7 42.8 24.9 65.4 18.8 20.8 45.9 45.0 39.0 36.2 28.4 22.4 23.3 44.5 25.8 19.7 14.3 22.8 28.9 31.9 30.5 23.0 21.7 43.9 21.8 30.3 24.2 46.2 18.3 25.4 33.6 17.1 17.3 15.0 45.2 36.0 15.7 28.1 24.3 29.8 23.6 35.4 27.9 22.7 24.6 26.2 43.9 35.1 7.3 28.4 21.7 25.3 28.1 16.3 24.4 16.0 31.6 27.4 22.5 47.9 23.5 34.2 29.3 20.2 29.1 42.4 19.8 17.7 32.5 21.9 31.8 19.6 0.2 22.3 30.0 23.1 48.4 21.2 64.4 17.2 8.2 14.4 5.9 30.3 30.1 42.5 28.6 16.8 75.4 21.6 18.5 39.7 54.4 25.3 17.1 14.3 0.1 22.4 25.6 18.7 0.3 27.7 8.7 28.9 0.0 8.3 0.8 9.6 9.0 6.3 8.4 9.6 8.9 10.4 8.2 9.9 9.1 1.0 9.2 6.5 10.1 10.5 8.3 44.0 43.7 43.6 46.3 45.7 42.8 45.9 45.0 44.5 43.9 46.2 45.2 9.3 19.2 12.7 0.0 2.5 0.0 0.0 0.0 0.0 0.0 14.2 11.3 0.0 0.0 9.9 22.0 0.0 34.8 5.4 0.0 39.2 15.0 0.0 7.3 10.5 4.0 0.0 0.0 0.0 11.8 26.7 6.2 0.0 8.8 1.3 27.6 0.0 0.0 10.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 10.3 0.0 0.0 0.0 0.0 11.6 0.0 0.0 2.1 0.0 0.0 22.4 8.7 0.0 0.0 0.0 6.4 0.0 0.0 0.0 0.0 30.9 2.1 24.4 0.0 0.0 NAXE "AIBP, APOA1BP, MGC119143, MGC119144, MGC119145, YJEFN1" ENSG00000163382 "NAD(P)HX epimerase" Q8NCW5 1 156591756-156609507 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted secreted proteins" "Lipid transport, Transport" Isomerase "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 136.7;Distal tubular cells: 201.5;Ductal cells: 112.8;Exocrine glandular cells: 100.1;Proximal tubular cells: 219.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043766, HPA048164" Enhanced Approved Nucleoplasm,Vesicles,Cytosol "Secreted to blood" NA NA 3300000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 35: Non-specific - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "Vesicles, Cytosol" "HPA043766: AB_2678660, HPA048164: AB_2680294" "unprognostic (1.27e-1)" "unprognostic (2.34e-2)" "unprognostic (2.49e-1)" "prognostic unfavorable (4.94e-4)" "unprognostic (7.38e-2)" "unprognostic (5.32e-2)" "unprognostic (2.46e-3)" "unprognostic (2.60e-1)" "unprognostic (1.72e-1)" "unprognostic (3.08e-3)" "unprognostic (3.23e-2)" "unprognostic (3.14e-2)" "unprognostic (2.15e-2)" "unprognostic (8.05e-2)" "unprognostic (7.43e-2)" "unprognostic (2.09e-1)" "unprognostic (3.81e-1)" 47.1 74.8 61.0 20.9 63.7 22.2 47.9 66.1 69.6 56.8 71.1 62.9 45.5 68.8 88.7 58.0 59.5 26.5 111.1 60.9 64.3 83.8 86.5 43.6 27.0 62.7 64.8 46.5 69.7 104.7 70.0 23.7 61.8 62.5 41.6 17.4 53.9 48.3 71.8 55.8 48.3 39.7 64.7 43.2 67.5 40.8 63.5 30.6 59.8 68.2 34.3 55.0 47.8 70.5 114.2 155.4 43.9 84.4 64.0 43.8 55.5 29.5 62.3 69.5 72.6 130.6 76.8 62.4 113.4 52.5 55.9 111.1 49.4 99.0 47.5 81.2 98.5 58.1 76.2 86.1 75.1 60.0 60.9 44.2 123.7 87.9 81.9 53.4 95.4 104.7 54.7 70.1 71.6 209.6 83.3 98.0 43.1 158.1 118.2 87.7 40.2 212.6 93.0 93.6 114.7 102.9 90.4 172.4 141.6 66.4 178.3 117.5 51.1 45.1 64.8 64.6 70.6 180.1 110.3 53.0 63.1 37.0 70.4 25.4 96.3 52.9 121.2 111.3 121.3 236.2 109.4 124.3 89.1 186.5 122.8 114.9 11.4 141.3 89.1 225.7 110.1 186.6 61.0 63.7 66.1 69.6 60.9 64.3 62.7 64.8 61.8 64.7 63.5 70.5 29.5 41.7 32.9 0.0 14.8 0.0 0.0 0.0 0.0 0.0 87.5 96.0 0.0 0.0 23.5 68.0 0.0 136.7 28.7 0.0 201.5 112.8 0.0 27.3 29.9 18.4 0.0 0.0 0.0 100.1 43.1 27.2 0.0 32.0 5.1 53.5 0.0 0.0 92.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.5 0.0 0.0 40.8 0.0 0.0 0.0 0.0 91.0 0.0 0.0 6.2 0.0 0.0 219.6 11.7 0.0 0.0 0.0 24.5 0.0 0.0 0.0 0.0 81.3 13.4 48.1 0.0 0.0 NDP "EVR2, norrin" ENSG00000124479 "Norrin cystine knot growth factor NDP" Q00604 X 43948776-43973395 "Disease related genes, Human disease related genes, Predicted secreted proteins" "Sensory transduction, Vision, Wnt signaling pathway" "Deafness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 35.8;ovary: 46.2" "Group enriched" "Detected in some" 4 "Granulosa cells: 181.3;Muller glia cells: 105.5" "Cancer enriched" "Detected in many" 5 "glioma: 25.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 16 "U-87 MG: 72.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003095 Supported Nucleoplasm,Nucleoli,Vesicles "Secreted to extracellular matrix" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 40: Granulosa cells - Unknown function" Vesicles "Nucleoplasm, Nucleoli" "HPA003095: AB_1079457" "unprognostic (1.12e-1)" "unprognostic (7.12e-2)" "unprognostic (2.27e-2)" "unprognostic (2.55e-3)" "unprognostic (6.84e-3)" "unprognostic (1.51e-1)" "unprognostic (9.09e-2)" "unprognostic (2.29e-1)" "unprognostic (1.22e-1)" "unprognostic (1.86e-1)" "unprognostic (1.40e-1)" "unprognostic (3.02e-2)" "unprognostic (2.22e-2)" "unprognostic (1.47e-1)" "unprognostic (1.13e-1)" "unprognostic (2.87e-3)" 0.5 0.0 31.5 0.0 33.4 0.0 3.3 30.9 35.8 20.9 22.4 0.2 0.1 15.4 22.0 0.0 20.8 0.4 0.3 31.5 29.6 0.1 0.0 0.0 0.2 30.1 33.2 46.2 0.0 0.2 0.1 4.0 31.6 7.1 0.2 19.2 0.1 13.1 0.0 0.6 0.2 11.4 32.4 0.1 0.3 1.0 34.2 0.0 0.2 0.0 0.2 0.5 2.3 32.4 0.0 0.0 0.2 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.1 0.0 0.0 1.5 0.0 0.0 0.1 1.9 0.0 0.0 0.0 1.8 0.0 4.3 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.2 0.0 0.0 2.2 0.0 0.0 0.0 72.9 0.0 4.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 31.5 33.4 30.9 35.8 31.5 29.6 30.1 33.2 31.6 32.4 34.2 32.4 0.0 0.0 0.0 29.0 0.0 0.1 0.0 1.2 0.0 0.6 1.3 0.1 0.3 0.0 0.5 0.0 0.0 0.1 0.1 0.0 0.0 2.0 0.0 9.1 17.7 0.2 0.0 0.0 4.2 0.0 0.3 0.9 0.0 17.0 0.0 181.3 0.0 0.0 0.1 0.0 0.8 0.0 2.0 0.0 0.0 0.7 13.4 0.6 0.0 0.0 0.0 105.5 0.0 1.5 9.5 1.2 0.0 9.8 0.0 0.0 0.0 0.0 0.0 4.1 0.0 0.0 5.4 0.1 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.2 NDRG1 "CAP43, DRG1, NDR1, RTP, TDD5" ENSG00000104419 "N-myc downstream regulated 1" Q92597 8 133237175-133302022 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cancer-related genes, Charcot-Marie-Tooth disease, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 613.9" "Cell type enhanced" "Detected in all" "Basal keratinocytes: 571.9;Distal enterocytes: 405.4;Horizontal cells: 588.9;Suprabasal keratinocytes: 667.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "hTCEpi: 606.9;hTERT-HME1: 1226.9;U-87 MG: 772.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006881 Approved Supported Microtubules,Cytosol NA NA 200000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 27: Brain & Skin - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 28: Keratinocytes - Keratinization" Cytosol Microtubules "HPA006881: AB_1078392" "unprognostic (6.96e-3)" "unprognostic (3.31e-3)" "unprognostic (8.53e-2)" "unprognostic (1.41e-3)" "unprognostic (1.54e-3)" "unprognostic (2.60e-2)" "prognostic unfavorable (1.47e-4)" "unprognostic (3.04e-3)" "unprognostic (5.33e-2)" "unprognostic (4.29e-2)" "unprognostic (9.09e-2)" "unprognostic (2.46e-1)" "prognostic unfavorable (4.13e-4)" "unprognostic (7.27e-2)" "unprognostic (1.91e-1)" "unprognostic (2.47e-3)" "unprognostic (4.28e-2)" 161.2 72.9 299.1 55.9 523.6 130.0 107.6 413.5 300.2 169.4 132.8 130.0 242.2 92.9 34.3 343.1 106.4 87.8 99.8 254.5 316.6 192.4 49.6 116.6 38.7 523.2 500.0 126.1 52.8 69.1 82.2 110.8 476.8 354.3 77.8 86.0 130.8 60.0 28.2 262.6 258.1 61.9 333.7 39.4 154.0 28.1 423.1 55.1 80.5 44.6 88.1 105.5 273.8 613.9 191.6 24.0 1.7 0.8 116.3 86.8 26.0 13.7 103.0 9.8 52.5 12.5 27.6 1.5 133.0 58.0 21.9 62.4 1.7 316.8 18.0 13.3 226.8 1.9 55.6 14.7 46.3 7.0 4.6 79.2 606.9 51.2 1226.9 124.2 45.2 27.9 2.0 138.3 17.2 11.0 19.1 20.8 3.0 69.8 155.8 1.7 19.4 86.2 29.7 28.0 13.8 13.0 31.0 312.1 73.3 48.6 1.3 20.0 58.5 84.4 43.6 40.7 10.4 96.3 280.3 0.8 772.5 69.5 161.5 10.9 4.3 0.0 5.8 3.4 9.1 1.6 5.3 6.9 6.0 1.4 3.9 3.1 4.0 1.5 4.2 13.0 8.1 3.7 299.1 523.6 413.5 300.2 254.5 316.6 523.2 500.0 476.8 333.7 423.1 613.9 123.0 144.2 47.4 14.4 23.6 571.9 141.3 207.3 42.1 68.8 28.6 31.2 20.6 80.1 102.9 187.6 2.1 12.8 68.1 405.4 33.2 33.2 5.3 57.4 59.0 217.7 22.1 17.4 7.7 13.7 138.2 90.5 151.4 167.7 22.2 41.0 112.8 64.0 16.5 588.9 5.7 140.9 83.4 31.1 109.5 5.9 49.0 42.7 101.4 28.1 25.7 81.2 14.4 20.6 136.2 62.9 155.9 44.0 23.5 264.3 402.5 87.5 38.7 40.3 46.0 65.2 44.3 1.2 7.1 113.0 667.4 43.4 45.7 32.6 124.7 280.8 NECAP1 DKFZP566B183 ENSG00000089818 "NECAP endocytosis associated 1" Q8NC96 12 8076939-8097881 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Endocytosis, Protein transport, Transport" Epilepsy "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA053980, HPA063300" Uncertain Approved Vesicles,Cytosol NA NA "Cluster 10: Basophils - Unknown function" "Cluster 58: Brain - Synaptic function" "Cluster 21: OE19 - Mitochondria" "Cluster 52: Non-specific - Transcription" Vesicles Cytosol "HPA053980: AB_2682331, HPA063300: AB_2684981" "unprognostic (1.73e-2)" "unprognostic (6.11e-2)" "unprognostic (2.01e-1)" "unprognostic (2.25e-1)" "unprognostic (4.87e-1)" "unprognostic (1.06e-3)" "unprognostic (1.03e-1)" "unprognostic (1.22e-1)" "unprognostic (4.56e-1)" "unprognostic (5.79e-3)" "unprognostic (5.72e-3)" "unprognostic (1.03e-1)" "unprognostic (1.72e-2)" "unprognostic (1.89e-2)" "unprognostic (2.64e-1)" "unprognostic (2.06e-1)" "unprognostic (5.94e-2)" 11.7 23.7 25.4 11.8 23.2 8.0 13.6 19.3 39.6 14.9 1.0 17.8 15.6 10.2 8.7 12.1 15.5 9.9 12.7 25.5 44.0 15.8 14.4 11.2 8.0 13.0 11.1 16.1 22.3 27.5 24.7 15.9 17.8 15.7 16.9 42.5 15.9 12.4 7.9 9.4 15.6 11.4 13.8 10.1 16.1 13.6 15.2 14.2 12.6 12.2 10.4 16.9 10.1 15.9 20.4 18.8 12.6 17.6 29.6 22.0 28.2 41.8 26.6 36.1 36.2 40.9 23.1 9.2 7.3 20.9 26.2 14.0 35.2 23.1 31.2 28.2 27.4 11.6 21.2 21.4 26.9 10.7 29.2 28.7 26.3 40.4 48.0 27.7 26.2 15.0 27.3 14.8 38.8 25.8 17.3 2.8 35.1 57.2 15.4 6.8 32.0 9.7 24.6 32.0 20.7 14.3 21.3 29.7 15.9 40.7 10.1 8.9 26.6 16.9 33.3 20.3 30.1 9.4 18.4 19.9 30.6 11.7 26.0 28.8 16.6 36.4 10.9 15.7 12.7 9.8 10.3 11.2 11.9 10.2 12.1 11.0 28.7 10.6 22.7 7.2 16.8 13.0 25.4 23.2 19.3 39.6 25.5 44.0 13.0 11.1 17.8 13.8 15.2 15.9 18.9 38.5 24.0 11.4 36.1 25.5 22.0 16.0 25.6 49.0 17.5 10.5 10.4 7.2 18.7 23.9 27.1 14.6 32.9 19.8 25.4 15.3 25.4 11.3 20.9 18.1 16.2 17.0 29.4 16.7 14.5 17.9 17.3 16.1 29.2 33.5 15.4 15.2 13.8 28.6 28.4 16.1 12.2 19.8 39.0 13.7 23.3 22.4 28.4 11.2 14.8 30.7 20.6 14.6 21.3 19.0 16.0 14.7 33.7 21.8 23.9 17.8 13.1 46.3 6.6 17.7 21.3 17.4 22.3 21.0 21.3 22.4 35.6 25.2 14.1 22.0 NEFH "NF-H, NFH" ENSG00000100285 "Neurofilament heavy" P12036 22 29480218-29491390 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Amyotrophic lateral sclerosis, Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 10 "brain: 544.0;prostate: 245.9" "Cell type enhanced" "Detected in many" "Inhibitory neurons: 20.9;monocytes: 34.6;Prostatic glandular cells: 44.0;Spermatogonia: 29.5;Theca cells: 49.7" "Cancer enriched" "Detected in many" 4 "prostate cancer: 130.0" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "non-classical monocyte: 4.7" "Lineage enriched" "Detected in single" 5 "monocytes: 4.7" "Cell line enriched" "Detected in many" 5 "SiHa: 182.2" "Low region specificity" "Detected in all" "Region enriched" "Detected in all" 5 "spinal cord: 1241.2" "CAB007786, HPA061615" Enhanced NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 70: Brain - Nervous system development" "Cluster 20: HeLa - Mitochondria" "Cluster 35: Glandular cells - Unknown function" "CAB007786: AB_598179, HPA061615: AB_2684568" "prognostic favorable (2.33e-6)" "unprognostic (6.17e-3)" "unprognostic (9.74e-2)" "unprognostic (3.20e-2)" "unprognostic (1.13e-1)" "unprognostic (6.19e-3)" "unprognostic (2.63e-4)" "unprognostic (2.95e-2)" "unprognostic (1.68e-1)" "unprognostic (6.42e-2)" "unprognostic (5.85e-2)" "unprognostic (6.64e-3)" "unprognostic (1.57e-3)" "unprognostic (1.54e-1)" "unprognostic (2.59e-1)" "unprognostic (1.31e-2)" "unprognostic (1.47e-1)" 0.6 21.1 17.7 1.6 18.9 0.6 1.4 143.1 544.0 0.6 0.0 1.4 0.4 0.5 0.7 0.3 0.5 0.4 0.4 7.8 57.3 0.9 0.3 0.4 0.9 494.1 56.2 20.0 0.3 0.9 15.4 0.6 376.1 245.9 0.5 39.6 0.9 0.6 0.3 0.2 0.9 1.0 58.3 1.2 0.6 7.7 172.9 0.7 0.3 0.3 1.0 0.4 1.2 147.3 0.0 0.0 2.4 0.6 0.1 0.3 1.8 3.2 0.0 0.0 0.0 0.0 0.0 0.1 0.8 1.9 9.5 0.1 0.0 0.0 0.0 9.0 34.2 0.1 24.2 0.0 1.4 0.2 10.5 3.5 0.0 0.5 0.0 0.0 1.3 0.0 28.0 0.0 11.7 0.0 12.0 1.2 17.4 0.0 0.0 0.1 0.1 1.9 0.0 0.0 1.5 19.5 182.2 0.1 0.0 5.9 0.0 9.9 25.2 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.0 1.0 0.0 0.4 2.7 0.8 0.1 0.5 0.4 0.6 0.0 0.1 0.5 0.0 0.2 4.7 0.1 0.2 0.6 17.7 18.9 143.1 544.0 7.8 57.3 494.1 56.2 376.1 58.3 172.9 147.3 0.7 0.0 0.0 3.9 1.0 0.1 1.0 0.1 2.2 3.2 1.4 5.3 0.9 1.5 0.0 1.8 2.1 1.4 1.6 0.5 0.0 0.2 0.4 0.3 7.7 1.0 0.0 5.9 13.6 0.4 1.1 2.4 0.0 0.8 1.3 8.8 0.0 0.0 5.6 8.4 20.9 0.0 0.0 4.2 2.3 1.0 5.9 5.2 1.8 5.6 34.6 3.6 0.0 2.0 2.6 0.3 0.0 3.0 1.7 44.0 0.2 1.0 0.0 9.9 6.6 1.3 2.0 4.4 29.5 3.0 0.1 0.4 1.7 49.7 0.2 0.7 NEFL "CMT1F, CMT2E, NF68, NFL, PPP1R110" ENSG00000277586 "Neurofilament light" P07196 8 24950955-24956721 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "brain: 675.9" "Cell type enhanced" "Detected in some" "Bipolar cells: 32.7;Distal tubular cells: 103.7;Enteroendocrine cells: 33.3;Excitatory neurons: 64.6;Horizontal cells: 30.3;Rod photoreceptor cells: 110.0" "Cancer enhanced" "Detected in many" "renal cancer: 24.0" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 5 "memory CD4 T-cell: 11.2" "Lineage enriched" "Detected in single" 113 "T-cells: 11.2" "Group enriched" "Detected in some" 4 "HEK 293: 456.2;PC-3: 145.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014850, HPA015021" Enhanced Supported Approved "Nucleoplasm,Intermediate filaments,Midbody" Yes NA 200000 "Cluster 32: T-cells - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 46: Photoreceptor cells - Phototransduction" "Nucleoplasm, Intermediate filaments" Midbody "HPA014850: AB_1854397, HPA015021: AB_2669135" "unprognostic (7.63e-2)" "unprognostic (1.36e-2)" "unprognostic (9.53e-2)" "unprognostic (6.81e-2)" "unprognostic (2.82e-2)" "unprognostic (6.69e-2)" "unprognostic (3.69e-2)" "unprognostic (3.78e-3)" "unprognostic (3.06e-1)" "unprognostic (1.60e-1)" "unprognostic (1.46e-2)" "unprognostic (1.94e-1)" "prognostic unfavorable (4.91e-4)" "unprognostic (5.76e-3)" "unprognostic (7.88e-2)" "unprognostic (3.97e-3)" "unprognostic (3.17e-3)" 0.1 18.0 35.4 1.3 36.7 0.0 0.0 103.6 675.9 2.0 0.0 2.5 0.6 0.1 0.3 5.4 1.3 0.1 0.1 50.9 75.6 5.0 0.0 0.0 0.1 425.7 41.1 0.2 0.2 0.1 4.0 0.0 231.3 1.8 1.5 89.5 0.0 15.6 0.0 0.9 1.9 1.1 33.9 0.2 0.8 1.7 216.1 12.7 0.7 0.1 0.3 0.0 1.4 184.0 0.0 0.6 68.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 29.7 0.0 0.6 0.0 0.0 456.2 0.0 0.0 0.0 21.6 0.0 1.0 8.3 2.0 0.1 1.4 0.0 0.0 0.0 0.0 0.1 2.2 0.0 0.0 0.0 18.8 0.0 145.4 0.0 0.0 0.0 31.7 4.2 30.9 31.6 11.2 0.0 1.9 2.2 0.0 0.0 0.0 2.2 31.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 4.8 0.0 0.0 0.0 0.1 0.0 0.0 0.0 11.2 1.2 0.0 0.0 2.3 0.1 0.0 0.0 0.0 0.0 0.2 1.5 35.4 36.7 103.6 675.9 50.9 75.6 425.7 41.1 231.3 33.9 216.1 184.0 0.1 0.0 0.0 23.2 0.0 0.0 0.0 0.0 0.6 32.7 0.0 0.0 3.2 0.0 0.0 0.0 8.4 0.0 0.1 0.1 103.7 0.1 0.4 0.1 0.3 3.7 33.3 0.0 64.6 0.0 0.0 0.4 0.0 0.0 0.0 0.3 0.0 0.0 0.0 30.3 29.1 0.1 0.0 0.0 0.0 0.7 0.0 0.2 0.0 27.2 0.1 27.8 0.0 14.6 18.4 0.0 0.1 9.4 0.0 0.0 0.0 0.2 0.0 110.0 0.0 0.1 0.2 0.0 13.2 1.5 0.0 0.0 1.6 1.4 0.0 0.0 NEK2 "NEK2A, NLK1, PPP1R111, RP67" ENSG00000117650 "NIMA related kinase 2" P51955 1 211658657-211675630 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Chromosome partition, Meiosis, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "bone marrow: 17.9;lymphoid tissue: 19.2;testis: 67.1" "Group enriched" "Detected in many" 4 "Early spermatids: 76.1;Spermatocytes: 244.2" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Region enhanced" "Detected in many" "cerebellum: 5.7" "Low region specificity" "Detected in all" "CAB017530, HPA064967" Enhanced Supported Nucleoplasm,Centrosome NA Yes "Cluster 41: Basophils - Cellular respiration" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" "Nucleoplasm, Centrosome" "CAB017530: AB_1126558, HPA064967: AB_2685393" "unprognostic (1.28e-1)" "unprognostic (2.33e-1)" "unprognostic (1.02e-1)" "unprognostic (8.51e-2)" "unprognostic (1.83e-1)" "unprognostic (1.35e-2)" "prognostic unfavorable (9.47e-6)" "prognostic unfavorable (9.11e-4)" "unprognostic (1.95e-2)" "unprognostic (2.00e-2)" "unprognostic (1.09e-3)" "unprognostic (8.49e-2)" "unprognostic (0.00e+0)" "unprognostic (8.21e-2)" "unprognostic (4.11e-2)" "unprognostic (1.25e-2)" "unprognostic (2.71e-1)" 0.7 0.4 0.5 5.3 0.4 17.9 1.5 0.9 0.6 1.1 0.6 5.9 7.4 1.3 0.5 4.4 2.2 0.8 0.4 0.5 0.3 0.3 0.7 0.7 9.0 0.4 0.2 0.4 0.1 0.1 0.0 3.2 0.3 2.5 7.6 1.5 0.8 0.2 0.4 4.3 6.9 2.0 0.2 1.7 2.7 67.1 0.6 19.2 0.4 0.2 10.6 1.3 1.6 0.9 86.0 60.5 45.3 32.6 2.6 4.5 49.7 32.4 30.1 55.4 47.5 32.3 81.7 45.1 15.2 25.2 35.1 44.5 39.9 24.2 69.6 69.5 33.2 21.6 51.4 44.2 0.4 43.2 28.3 1.4 2.9 42.9 45.9 13.4 36.3 45.2 59.9 76.9 56.0 23.6 47.3 28.8 43.0 55.0 30.5 46.2 69.2 68.7 19.7 24.2 41.0 45.0 46.6 51.5 39.3 38.4 79.4 25.1 19.0 27.6 54.1 54.8 88.3 31.6 62.6 59.6 24.1 32.6 46.8 1.2 0.1 0.1 0.1 0.1 0.0 0.5 0.1 0.1 0.0 0.4 0.3 0.2 0.7 1.5 0.1 0.2 1.6 0.3 0.5 0.4 0.9 0.6 0.5 0.3 0.4 0.2 0.3 0.2 0.6 0.9 0.1 0.0 0.5 0.3 1.7 2.9 0.7 3.8 0.6 11.3 1.9 2.2 0.5 0.0 2.9 0.0 0.0 9.4 0.8 1.9 0.0 0.2 76.1 15.2 0.7 0.8 0.0 39.6 0.8 0.2 14.1 1.4 5.6 1.5 0.0 3.6 3.6 0.7 5.8 3.3 0.0 3.2 10.2 2.5 1.1 39.0 2.5 2.1 0.0 0.0 0.0 1.6 2.1 0.0 0.1 0.0 2.5 0.7 5.4 0.7 2.1 0.1 5.2 1.8 6.6 0.0 1.5 244.2 26.1 8.6 1.7 1.4 2.0 0.9 9.5 1.4 NEUROD2 "bHLHa1, NDRF" ENSG00000171532 "Neuronal differentiation 2" Q15784 17 39603536-39609777 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Differentiation, Neurogenesis, Transcription, Transcription regulation" "Activator, Developmental protein, DNA-binding" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 81 "brain: 94.7;choroid plexus: 37.3" "Cell type enhanced" "Detected in some" "Bipolar cells: 10.1;Cone photoreceptor cells: 4.2;Enteroendocrine cells: 23.8;Excitatory neurons: 14.9" "Cancer enhanced" "Detected in some" "cervical cancer: 0.7;glioma: 0.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 139 "SCLC-21H: 29.6" "Low region specificity" "Detected in many" "Region enhanced" "Detected in many" "cerebellum: 68.0;hippocampal formation: 76.9" NA NA "Cluster 65: Brain - Ion transport" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "unprognostic (5.70e-2)" "unprognostic (3.85e-2)" "unprognostic (2.87e-1)" "unprognostic (3.51e-3)" "unprognostic (2.44e-2)" "unprognostic (3.04e-1)" "unprognostic (4.69e-1)" "unprognostic (1.72e-1)" "unprognostic (2.16e-1)" "unprognostic (3.96e-1)" "unprognostic (6.15e-2)" "unprognostic (4.09e-2)" "unprognostic (3.21e-6)" "unprognostic (4.20e-1)" "unprognostic (2.66e-1)" "unprognostic (2.52e-2)" "unprognostic (2.57e-3)" 0.0 0.0 53.0 0.0 58.9 0.0 0.0 74.5 94.7 0.0 37.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 73.9 37.2 0.0 0.0 0.0 0.0 56.0 38.1 0.0 0.0 0.0 0.0 0.0 55.8 0.0 0.0 0.8 0.0 0.0 0.2 0.2 0.0 0.0 38.5 0.0 0.1 0.0 37.2 0.0 0.0 0.0 0.0 0.0 0.0 58.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 29.6 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.0 0.0 53.0 58.9 74.5 94.7 73.9 37.2 56.0 38.1 55.8 38.5 37.2 58.1 0.1 0.0 0.0 1.0 0.2 0.3 1.1 0.0 0.0 10.1 0.2 0.3 1.5 0.0 0.0 0.0 4.2 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.4 23.8 0.0 14.9 0.0 0.1 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.4 0.4 0.0 0.0 0.3 0.0 0.6 0.2 0.0 1.9 0.1 0.6 1.0 0.5 0.9 0.0 0.0 0.0 0.0 1.5 0.0 0.1 0.0 1.8 0.0 1.7 0.4 0.6 0.3 0.0 0.0 0.8 0.4 0.0 0.1 1.1 NGF NGFB ENSG00000134259 "Nerve growth factor" P01138 1 115285904-115338770 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins" "Growth factor, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor" "Cancer-related genes, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 20.8;ovary: 18.9" "Cell type enhanced" "Detected in some" "Inhibitory neurons: 15.7;Leydig cells: 29.2;Sertoli cells: 118.3;Smooth muscle cells: 51.6" "Cancer enhanced" "Detected in many" "renal cancer: 4.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ: 87.9;BJ hTERT+ SV40 Large T+: 30.1;GAMG: 46.2;hTEC/SVTERT24-B: 29.8;hTERT-RPE1: 49.0;U-2197: 60.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in some" "Secreted in other tissues" NA NA 40000 "Cluster 89: Fibroblasts - ECM organization" "Cluster 18: U-2197 - ECM organization" "Cluster 10: Non-specific - Unknown function" "unprognostic (7.55e-2)" "unprognostic (2.66e-2)" "unprognostic (1.53e-3)" "unprognostic (8.85e-2)" "unprognostic (4.12e-1)" "prognostic unfavorable (1.80e-4)" "unprognostic (1.03e-1)" "unprognostic (5.30e-2)" "unprognostic (8.73e-3)" "unprognostic (4.28e-1)" "unprognostic (1.79e-1)" "unprognostic (2.05e-1)" "prognostic unfavorable (8.08e-7)" "unprognostic (1.15e-3)" "unprognostic (2.13e-1)" "unprognostic (7.99e-3)" "unprognostic (1.62e-4)" 13.9 2.5 1.7 1.6 1.7 0.0 4.0 1.3 2.1 7.1 2.1 5.0 0.1 8.8 1.4 1.1 13.2 1.7 20.8 1.6 2.2 6.4 4.0 1.6 0.5 1.9 1.7 18.9 0.8 0.4 2.7 1.1 1.9 2.6 0.6 0.1 2.1 1.0 0.9 0.9 2.1 4.0 1.4 3.7 2.1 1.1 1.9 0.2 3.3 1.1 0.1 5.5 5.0 1.6 0.0 0.3 0.0 0.0 1.8 0.1 0.0 87.9 9.9 30.1 21.9 0.0 0.0 0.0 1.9 21.1 46.2 3.6 0.0 0.6 13.8 0.0 0.2 0.0 0.6 0.0 12.1 0.0 0.0 0.1 0.6 29.8 21.6 49.0 0.0 0.1 0.0 0.0 0.6 0.0 0.1 0.0 3.0 0.0 1.3 0.0 1.2 0.0 0.0 0.0 1.1 0.3 1.6 0.6 0.0 3.9 0.0 0.0 0.8 1.8 3.7 60.0 3.5 0.0 0.0 0.0 3.6 0.0 19.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 1.7 1.3 2.1 1.6 2.2 1.9 1.7 1.9 1.4 1.9 1.6 0.4 0.0 0.0 0.3 0.0 3.1 0.5 3.9 0.0 0.0 0.1 1.5 0.7 1.5 0.2 0.0 0.0 3.0 0.0 0.0 0.0 5.6 0.2 0.2 0.8 0.8 0.0 0.0 0.3 0.0 1.3 7.3 0.0 0.3 0.0 0.0 4.2 0.0 0.1 0.0 15.7 0.0 2.0 0.0 1.7 0.4 29.2 0.2 1.8 1.9 0.0 0.0 0.0 12.1 0.5 0.1 0.0 6.0 0.0 0.6 0.0 0.0 0.1 0.0 118.3 0.8 51.6 0.3 1.0 0.0 2.3 2.5 0.6 0.0 0.0 0.3 NHLRC1 "bA204B7.2, EPM2B" ENSG00000187566 "NHL repeat containing E3 ubiquitin protein ligase 1" Q6VVB1 6 18120440-18122677 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, Ubl conjugation pathway" Transferase "Disease variant, Epilepsy, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Erythroid cells: 5.0;Exocrine glandular cells: 3.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "EFO-21: 6.8;K-562: 6.1;SCLC-21H: 6.1" "Low region specificity" "Detected in all" HPA066030 Uncertain Vesicles NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 15: Liver - Metabolism" "Cluster 1: K-562 - Erythropoiesis" "Cluster 4: Macrophages - Innate immune response" Vesicles "HPA066030: " "unprognostic (1.61e-1)" "unprognostic (1.39e-1)" "unprognostic (7.95e-2)" "prognostic unfavorable (9.01e-4)" "unprognostic (6.95e-3)" "unprognostic (2.45e-1)" "unprognostic (1.09e-1)" "unprognostic (3.69e-1)" "unprognostic (2.39e-1)" "unprognostic (7.17e-2)" "unprognostic (5.07e-3)" "unprognostic (1.28e-1)" "unprognostic (2.32e-2)" "unprognostic (3.19e-1)" "unprognostic (2.33e-1)" "unprognostic (2.77e-2)" "prognostic favorable (5.30e-4)" 1.2 1.4 2.0 0.8 2.3 1.1 2.0 1.5 2.6 0.8 0.8 1.5 1.4 0.8 2.6 1.1 1.4 0.6 1.8 2.4 1.9 0.8 4.1 1.2 0.6 2.5 1.8 1.4 1.8 1.2 1.2 0.5 2.7 1.2 1.3 2.0 2.3 1.0 2.6 3.8 1.9 0.8 1.6 1.1 1.3 0.7 2.0 1.0 1.6 1.5 0.8 0.9 0.8 3.6 2.6 1.5 0.6 0.0 1.3 1.2 0.0 2.6 0.8 0.9 0.5 0.1 2.1 0.0 6.8 1.9 0.2 3.0 0.0 1.7 0.7 0.1 0.9 0.4 1.0 0.1 2.0 0.0 1.7 2.1 2.5 1.0 0.9 0.6 2.1 0.0 6.1 0.1 2.1 2.8 0.0 0.0 0.0 0.3 1.5 0.0 0.0 0.1 1.4 2.8 6.1 0.1 5.3 4.3 1.6 0.6 3.1 1.7 0.4 0.2 1.3 1.8 0.1 0.1 0.0 0.1 0.1 0.0 2.6 0.5 4.4 0.4 0.6 4.9 0.8 2.3 1.1 0.5 4.7 1.3 1.5 1.0 0.3 1.6 2.3 0.6 1.3 1.8 2.0 2.3 1.5 2.6 2.4 1.9 2.5 1.8 2.7 1.6 2.0 3.6 0.8 0.0 2.2 0.3 0.2 1.9 1.4 1.4 1.8 0.4 1.5 2.0 0.9 1.5 2.3 0.0 0.0 0.4 0.0 0.2 0.0 2.9 0.0 0.6 1.3 0.3 3.5 5.0 1.0 3.7 0.0 0.8 1.5 0.5 1.3 0.8 0.4 1.1 1.2 0.0 0.7 0.3 0.0 0.8 0.6 0.0 0.6 1.5 1.8 1.0 0.5 1.1 0.0 1.5 1.2 2.0 0.3 0.0 0.0 0.2 0.6 1.2 0.8 1.0 0.0 0.3 0.8 0.2 0.2 1.3 1.8 0.4 0.1 1.1 0.5 0.5 NHS ENSG00000188158 "NHS actin remodeling regulator" Q6T4R5 X 17375200-17735994 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" Cataract "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in many" 6 "Inhibitory neurons: 264.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in single" "neutrophil: 1.3" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "EFO-21: 12.7;RPTEC TERT1: 19.2;RT4: 12.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA031497, HPA076257" Uncertain Supported "Cell Junctions" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Cell Junctions" "HPA031497: AB_10610144, HPA076257: AB_2686789" "unprognostic (1.39e-2)" "unprognostic (3.34e-1)" "unprognostic (1.17e-1)" "prognostic favorable (1.68e-4)" "unprognostic (2.58e-1)" "unprognostic (1.69e-1)" "unprognostic (9.92e-3)" "unprognostic (3.27e-3)" "unprognostic (1.08e-1)" "unprognostic (1.78e-1)" "unprognostic (1.61e-3)" "unprognostic (2.54e-1)" "unprognostic (1.72e-2)" "unprognostic (1.07e-2)" "unprognostic (1.21e-1)" "unprognostic (8.83e-3)" "unprognostic (1.83e-3)" 3.2 4.1 2.9 1.3 2.4 0.4 2.8 0.0 4.2 6.1 6.8 4.1 0.8 4.8 2.8 1.8 2.7 1.6 0.9 1.8 2.5 5.1 0.2 1.1 0.5 3.3 2.8 3.5 0.5 0.3 2.8 2.6 3.0 3.4 1.6 7.8 2.0 2.7 0.4 2.3 1.5 2.5 1.7 1.0 2.2 2.5 3.8 2.2 2.6 0.7 0.5 4.0 3.7 0.9 7.9 3.1 5.5 0.0 0.1 0.2 8.7 3.5 2.4 1.5 0.8 0.3 1.5 0.5 12.7 2.4 7.5 6.8 3.5 4.4 2.2 0.1 1.1 0.0 5.4 0.0 0.0 0.0 0.0 0.7 3.1 0.1 6.8 6.7 0.0 0.0 0.0 0.0 0.8 3.8 0.0 0.0 6.7 3.6 2.0 0.0 0.0 0.3 19.2 12.0 1.4 2.8 9.6 0.0 0.0 3.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 8.0 0.1 8.4 0.0 0.4 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 1.3 0.2 0.0 0.0 0.0 0.1 2.9 2.4 0.0 4.2 1.8 2.5 3.3 2.8 3.0 1.7 3.8 0.9 0.6 3.2 0.0 22.5 0.0 8.3 10.6 4.6 8.6 11.4 2.0 2.4 1.7 0.0 14.7 1.8 22.9 6.0 0.1 1.3 5.9 0.8 0.9 12.4 20.1 3.5 4.2 0.0 40.1 2.2 5.4 6.1 3.6 25.0 0.0 0.2 0.7 0.0 1.4 3.3 264.4 1.9 2.0 4.6 2.6 2.3 16.8 2.4 3.6 40.3 5.0 11.9 0.0 14.1 8.1 6.8 2.4 31.2 0.0 7.0 0.9 7.8 8.2 18.9 6.6 2.0 11.9 0.3 0.6 5.1 3.8 2.6 0.9 4.5 4.3 12.8 NIPA1 "MGC35570, SLC57A1, SPG6" ENSG00000170113 "NIPA magnesium transporter 1" Q7RTP0 15 22773063-22829789 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Ion transport, Transport" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 40.2" "Cell type enhanced" "Detected in many" "Excitatory neurons: 36.2;Inhibitory neurons: 33.8;Oligodendrocytes: 65.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "plasmacytoid DC: 3.9" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA023269 Uncertain NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 44: HDLM-2 - Immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA023269: AB_1854485" "unprognostic (1.64e-2)" "unprognostic (7.60e-2)" "unprognostic (2.61e-2)" "unprognostic (2.13e-1)" "unprognostic (2.83e-1)" "unprognostic (1.79e-1)" "unprognostic (3.31e-2)" "unprognostic (2.13e-2)" "unprognostic (2.77e-1)" "unprognostic (2.42e-2)" "unprognostic (6.25e-2)" "unprognostic (6.32e-2)" "unprognostic (6.95e-2)" "unprognostic (8.80e-2)" "unprognostic (1.62e-1)" "unprognostic (8.42e-3)" "unprognostic (8.66e-2)" 3.1 4.2 27.7 3.7 36.9 1.2 2.8 36.8 38.1 3.7 17.9 4.6 6.5 2.2 2.1 4.3 2.5 4.8 3.5 22.8 28.7 6.2 5.7 4.7 5.3 35.4 36.9 1.5 5.7 8.7 3.6 3.5 33.8 6.7 4.3 6.2 3.6 3.4 2.5 4.9 6.6 2.6 36.1 4.2 6.4 4.3 36.0 8.2 7.3 3.5 5.5 3.2 3.5 40.2 14.9 17.4 5.4 12.4 6.9 5.6 3.8 17.6 12.7 8.5 7.1 13.3 7.4 6.9 13.5 7.3 17.4 9.7 16.0 4.6 10.1 40.2 9.8 10.8 10.8 11.4 8.3 0.1 20.8 1.7 15.2 5.5 9.2 13.6 8.2 15.2 8.4 11.3 4.8 5.6 5.9 9.7 5.9 15.9 18.2 12.1 7.7 5.4 13.0 14.9 15.2 15.4 13.2 1.6 16.7 7.0 10.3 13.8 15.4 23.9 12.2 10.1 27.2 12.7 13.6 12.4 12.3 0.0 15.6 0.4 0.1 0.2 0.6 0.0 0.6 0.9 0.7 0.6 0.5 1.1 0.4 0.3 0.3 0.3 0.0 3.9 0.8 0.3 27.7 36.9 36.8 38.1 22.8 28.7 35.4 36.9 33.8 36.1 36.0 40.2 5.9 12.8 5.9 14.4 7.4 8.8 4.0 5.9 2.2 4.1 4.4 3.0 4.3 15.7 5.2 5.5 6.2 2.6 10.5 9.9 3.9 5.7 3.3 3.6 2.4 5.9 3.0 4.0 36.2 11.6 2.1 4.5 10.2 5.7 0.0 4.1 4.6 6.0 4.1 5.0 33.8 7.1 2.0 4.4 6.9 4.2 2.1 2.9 5.4 4.7 3.8 4.7 4.1 15.6 65.2 17.7 6.8 3.0 7.2 8.6 11.8 5.8 6.2 6.6 19.7 3.0 3.6 3.4 8.5 4.2 14.9 1.5 7.1 1.6 7.5 7.3 NMNAT1 "LCA9, NMNAT, PNAT1" ENSG00000173614 "Nicotinamide nucleotide adenylyltransferase 1" Q9HAN9 1 9943428-9985501 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Pyridine nucleotide biosynthesis" "Nucleotidyltransferase, Transferase" "Disease variant, Leber congenital amaurosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA059447 Approved Supported "Nucleoplasm,Nuclear bodies" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Nuclear bodies" "HPA059447: AB_2684022" "unprognostic (1.94e-1)" "unprognostic (3.81e-3)" "unprognostic (7.54e-3)" "unprognostic (1.01e-1)" "unprognostic (3.50e-1)" "unprognostic (1.73e-1)" "unprognostic (1.56e-1)" "unprognostic (2.29e-1)" "unprognostic (4.45e-3)" "unprognostic (4.55e-2)" "unprognostic (1.12e-1)" "unprognostic (3.57e-1)" "prognostic favorable (3.85e-14)" "unprognostic (3.11e-3)" "unprognostic (1.17e-1)" "unprognostic (1.47e-3)" "unprognostic (5.16e-2)" 5.2 7.4 5.4 4.4 6.0 2.5 5.7 4.8 7.7 5.4 9.2 9.0 6.0 3.8 5.8 5.2 4.8 3.4 10.7 5.1 5.2 8.2 7.8 3.2 4.3 5.6 5.4 2.9 4.9 8.2 3.8 3.7 5.5 4.5 9.0 5.3 5.2 5.4 23.3 5.7 6.1 5.0 4.7 5.0 4.4 4.3 5.9 4.2 7.3 16.9 4.6 4.0 3.6 7.2 4.6 5.4 7.5 7.1 13.4 12.2 1.8 9.1 7.2 10.3 6.7 2.4 7.7 4.8 5.7 12.9 4.5 4.6 9.4 12.4 11.0 10.4 4.8 7.6 3.0 7.6 11.4 6.7 7.7 13.3 14.2 12.1 17.4 9.5 10.2 10.4 9.7 3.1 10.9 8.0 3.8 4.4 0.9 10.2 10.2 4.2 4.7 2.7 11.9 2.5 5.4 2.8 11.8 9.7 10.4 3.8 3.5 7.2 10.2 4.1 3.3 8.7 4.2 4.5 4.3 4.5 7.1 13.8 8.6 7.5 3.7 3.2 1.6 2.6 0.8 4.9 1.6 1.9 3.3 2.3 1.4 1.8 9.1 2.5 3.9 3.2 1.5 1.8 5.4 6.0 4.8 7.7 5.1 5.2 5.6 5.4 5.5 4.7 5.9 7.2 5.6 3.2 4.4 10.1 3.7 2.3 5.6 14.3 2.2 7.7 6.1 5.1 14.4 4.3 7.3 7.3 6.2 10.1 3.7 18.8 23.5 9.1 7.8 5.5 8.1 7.9 3.0 2.1 13.0 6.9 4.7 5.7 4.1 6.1 4.5 9.2 7.5 9.0 12.9 10.1 14.3 7.6 12.2 10.3 2.7 3.7 6.5 7.2 5.4 4.7 13.5 9.6 12.3 6.0 13.2 6.0 6.2 6.4 0.9 5.9 19.0 14.3 8.6 7.1 6.6 5.9 5.1 17.3 8.3 3.6 1.8 9.0 3.6 13.1 14.5 4.8 NOP56 "NOL5A, SCA36" ENSG00000101361 "NOP56 ribonucleoprotein" O00567 20 2652593-2658393 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Ribosome biogenesis" Ribonucleoprotein "Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA049918, CAB075757" Supported Enhanced "Nucleoli fibrillar center" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" "Nucleoli fibrillar center" "CAB075757: AB_2665763, HPA049918: AB_2680952" "unprognostic (2.82e-1)" "unprognostic (2.97e-1)" "unprognostic (2.18e-1)" "prognostic unfavorable (1.24e-4)" "unprognostic (1.01e-1)" "unprognostic (1.25e-1)" "prognostic unfavorable (1.59e-7)" "unprognostic (2.63e-2)" "prognostic unfavorable (6.77e-4)" "unprognostic (7.11e-2)" "unprognostic (2.59e-2)" "unprognostic (9.87e-2)" "prognostic unfavorable (2.22e-16)" "unprognostic (1.04e-2)" "unprognostic (2.53e-1)" "unprognostic (1.12e-2)" "unprognostic (2.42e-1)" 41.4 31.3 39.9 42.6 39.7 60.4 37.1 38.8 59.7 30.9 35.3 33.8 28.8 39.9 34.7 37.1 50.7 26.3 30.9 41.1 45.8 29.8 30.5 25.9 53.5 40.4 40.6 49.7 38.6 27.1 31.5 37.4 43.4 31.1 39.9 21.0 27.1 35.6 43.2 38.4 28.1 52.0 39.9 37.7 25.9 28.3 45.4 51.9 33.4 29.2 62.2 52.4 28.4 44.4 152.8 147.3 108.4 108.0 122.8 89.8 184.2 150.4 97.3 198.3 134.9 204.3 122.2 330.5 82.7 104.2 117.7 253.3 287.5 221.4 196.6 93.5 171.4 195.0 76.0 225.3 125.9 179.4 91.3 123.6 137.2 254.8 260.4 78.2 117.4 153.1 215.7 151.2 138.1 103.1 317.8 214.1 233.8 270.9 180.9 257.2 156.2 188.5 120.8 146.7 115.5 101.1 171.0 193.4 302.8 115.7 167.6 152.7 91.6 170.2 115.9 132.6 227.2 91.9 186.0 274.0 45.9 209.4 128.5 5.1 23.2 18.9 33.0 26.4 41.1 35.8 35.9 36.6 23.6 32.4 34.0 34.0 1.8 33.6 19.8 41.1 33.4 24.8 39.9 39.7 38.8 59.7 41.1 45.8 40.4 40.6 43.4 39.9 45.4 44.4 75.0 44.8 59.8 14.0 89.3 96.4 103.6 76.4 88.2 39.5 62.9 78.6 39.0 42.9 100.1 23.9 62.6 117.5 132.2 71.8 25.4 78.2 8.0 64.6 100.6 73.3 72.3 93.2 24.6 86.5 124.2 87.5 44.4 48.5 79.1 97.5 52.5 40.9 86.9 50.5 24.1 81.2 54.9 46.8 45.9 14.0 57.2 57.5 30.2 12.2 64.9 32.8 80.3 18.1 21.5 75.6 34.6 54.9 79.6 92.0 38.7 53.8 81.2 37.6 26.3 110.0 141.5 50.3 185.9 89.1 81.7 56.5 102.6 99.4 110.0 58.0 NOTCH2NLC ENSG00000286219 "Notch 2 N-terminal like C" P0DPK4 1 149390614-149468030 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" "Notch signaling pathway" Neurodegeneration "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "hTERT-HME1: 74.2;U-266/70: 121.3" "Secreted to blood" NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 29: U-266 - Adaptive immune response" 7.3 2.0 9.6 5.5 8.2 18.0 12.1 6.4 16.4 13.2 14.5 5.4 3.5 6.4 9.8 9.8 7.7 6.4 6.9 10.4 9.3 3.9 21.6 6.1 8.3 10.0 9.0 7.1 5.7 7.6 5.6 8.1 9.5 6.1 14.3 6.8 8.1 2.5 12.7 2.6 5.2 7.3 7.3 3.1 20.8 10.6 7.4 6.1 3.9 8.3 8.4 8.8 14.2 6.0 4.0 5.0 9.0 11.1 2.5 4.5 39.9 17.9 23.8 3.6 12.2 2.2 3.6 17.1 9.6 5.0 5.1 19.7 10.8 7.1 3.4 11.7 43.8 1.8 37.9 6.1 3.7 33.5 8.1 28.3 74.2 10.7 14.4 8.3 3.1 50.7 17.0 29.8 5.1 7.7 1.6 8.6 13.6 4.8 7.9 27.3 17.9 16.4 0.5 0.4 12.9 12.3 2.0 5.0 10.6 9.5 12.8 5.4 8.8 9.5 9.8 121.3 35.9 7.6 11.9 6.4 8.0 17.8 29.3 47.3 3.6 21.4 5.0 57.7 5.9 5.8 44.3 26.6 5.9 4.0 14.1 8.3 18.9 23.6 8.2 11.3 9.6 8.2 6.4 16.4 10.4 9.3 10.0 9.0 8.1 7.3 10.6 8.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 NPRL2 "NPR2, NPR2L, TUSC4" ENSG00000114388 "NPR2 like, GATOR1 complex subunit" Q8WTW4 3 50347330-50350826 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "GTPase activation" "Disease variant, Epilepsy, Tumor suppressor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 94.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038196, HPA038197" Approved NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 39: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 63: NK-cells & T-cells - Immune response" "HPA038196: AB_10675631, HPA038197: AB_10671523" "unprognostic (7.25e-3)" "unprognostic (2.01e-2)" "unprognostic (3.41e-2)" "unprognostic (2.81e-1)" "unprognostic (6.44e-2)" "unprognostic (2.11e-2)" "unprognostic (3.06e-3)" "prognostic favorable (1.59e-4)" "unprognostic (7.86e-2)" "unprognostic (1.22e-2)" "unprognostic (1.60e-3)" "unprognostic (5.69e-2)" "unprognostic (4.28e-2)" "unprognostic (4.55e-2)" "unprognostic (3.14e-1)" "unprognostic (4.49e-1)" "unprognostic (3.06e-2)" 4.9 9.2 9.4 5.0 9.7 5.1 7.4 10.0 11.0 9.0 9.4 8.3 5.3 5.3 11.1 6.8 8.8 6.2 10.3 10.0 11.1 9.3 12.9 5.1 8.0 9.7 10.7 7.8 16.4 12.1 9.0 5.7 10.1 7.7 8.5 5.7 12.1 8.1 14.7 7.5 5.6 6.9 10.0 6.8 7.2 7.8 9.9 9.6 8.3 18.0 9.2 5.8 5.3 10.3 12.2 11.9 7.9 14.5 22.5 11.8 8.2 6.4 16.5 17.1 16.8 9.3 11.0 13.9 9.5 11.9 8.6 6.7 18.1 18.5 12.3 10.0 12.9 16.6 10.0 18.2 20.2 20.7 21.9 14.3 19.3 21.8 15.0 11.5 16.8 20.2 9.5 13.6 14.7 2.4 19.3 14.8 8.7 37.2 33.4 7.1 5.0 34.5 19.7 12.1 6.0 14.1 7.3 11.1 12.5 8.2 17.5 10.4 6.0 7.2 9.2 13.8 11.7 16.8 22.0 11.8 14.6 25.5 7.3 40.6 17.4 46.7 72.7 18.1 63.4 23.2 36.4 62.7 20.6 21.1 30.8 48.5 22.9 64.1 20.8 16.6 49.8 50.7 9.4 9.7 10.0 11.0 10.0 11.1 9.7 10.7 10.1 10.0 9.9 10.3 13.4 9.6 11.9 7.8 19.0 12.0 9.8 26.7 14.8 18.4 18.2 19.9 13.2 15.7 16.3 14.7 20.9 27.4 31.4 15.8 37.2 15.9 94.6 8.1 9.4 11.3 11.9 30.3 7.2 15.0 21.5 12.9 18.3 7.1 19.0 12.6 11.7 14.8 14.7 25.2 7.9 20.9 38.7 13.2 10.3 66.6 19.3 7.4 12.4 2.8 15.0 15.0 68.0 5.0 6.5 12.2 12.8 15.1 19.4 7.7 30.7 30.0 15.6 26.4 6.6 11.1 22.1 16.8 14.9 15.4 12.5 9.0 29.3 16.0 18.8 7.7 NPRL3 "C16orf35, CGTHBA, HS-40, MARE, NPR3, RMD11" ENSG00000103148 "NPR3 like, GATOR1 complex subunit" Q12980 16 84271-138677 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "GTPase activation" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Erythroid cells: 134.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011741 Uncertain Approved Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 6: Erythroid cells - Oxygen transport" Cytosol "HPA011741: AB_1845577" "unprognostic (1.34e-1)" "unprognostic (1.32e-1)" "unprognostic (3.13e-2)" "unprognostic (1.13e-1)" "unprognostic (1.24e-2)" "unprognostic (4.87e-2)" "unprognostic (6.18e-3)" "unprognostic (9.50e-2)" "unprognostic (7.28e-2)" "unprognostic (4.85e-2)" "unprognostic (9.07e-3)" "unprognostic (1.68e-1)" "unprognostic (3.15e-2)" "unprognostic (8.69e-2)" "unprognostic (1.65e-1)" "unprognostic (3.11e-1)" "unprognostic (2.73e-1)" 9.6 10.4 17.5 7.2 18.2 19.1 8.5 16.7 22.2 10.1 15.7 6.5 7.3 10.5 5.2 9.3 12.1 6.3 8.9 17.7 18.0 8.0 10.0 7.8 9.4 17.1 18.1 12.9 10.9 12.7 11.7 6.6 16.9 8.8 4.8 7.1 11.0 7.1 15.5 9.9 5.6 7.2 15.5 8.3 6.8 9.4 18.2 7.0 11.0 10.3 6.6 6.5 8.2 18.2 14.5 29.0 12.6 32.2 33.7 16.9 19.8 17.2 16.8 21.3 16.6 46.6 25.6 26.5 22.5 25.5 13.8 17.0 20.5 29.7 12.3 29.2 16.0 38.8 17.3 34.2 31.1 15.9 25.6 20.7 22.2 28.4 24.9 16.0 20.3 21.1 38.6 24.6 19.1 51.2 17.6 12.3 11.9 10.0 20.8 30.1 10.8 37.9 21.6 12.2 26.9 17.1 22.8 30.1 14.3 6.5 22.2 11.1 19.2 32.9 18.2 20.0 13.3 25.9 14.7 37.7 1.1 19.2 18.3 0.0 2.4 0.3 3.0 2.2 3.2 2.0 2.6 2.5 3.5 2.0 2.5 2.9 0.2 2.0 3.1 2.6 2.9 2.2 17.5 18.2 16.7 22.2 17.7 18.0 17.1 18.1 16.9 15.5 18.2 18.2 10.4 12.8 11.7 30.0 22.2 9.4 17.6 15.7 14.8 58.1 16.6 16.8 9.0 12.8 9.2 11.0 66.7 24.6 20.4 6.8 23.5 16.4 31.0 11.8 18.1 13.0 9.6 134.5 29.7 8.9 35.2 17.3 15.8 9.4 3.8 49.2 15.7 10.2 19.7 55.5 30.8 11.7 10.2 14.2 6.4 73.8 22.7 12.8 12.4 15.9 16.4 29.5 79.3 21.1 40.4 11.4 6.6 19.5 14.0 23.3 8.0 23.9 11.0 57.2 6.6 15.6 14.9 62.2 43.0 16.0 5.5 15.3 18.8 28.2 14.4 10.4 NR2E3 "PNR, rd7, RP37" ENSG00000278570 "Nuclear receptor subfamily 2 group E member 3" Q9Y5X4 15 71792638-71818259 "Disease related genes, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors" "Sensory transduction, Transcription, Transcription regulation, Vision" "DNA-binding, Receptor, Repressor" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 131 "retina: 131.4" "Cell type enriched" "Detected in some" 30 "Rod photoreceptor cells: 1357.8" "Low cancer specificity" "Detected in single" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 46: Photoreceptor cells - Phototransduction" "unprognostic (9.90e-2)" "unprognostic (2.50e-1)" "unprognostic (8.25e-3)" "unprognostic (2.63e-3)" "unprognostic (2.04e-1)" "unprognostic (1.01e-1)" "unprognostic (9.85e-3)" "unprognostic (3.60e-2)" "unprognostic (2.59e-1)" "unprognostic (2.89e-1)" "unprognostic (3.51e-1)" "unprognostic (3.65e-1)" "unprognostic (4.75e-2)" "unprognostic (2.11e-2)" "unprognostic (2.75e-1)" "unprognostic (2.55e-1)" "unprognostic (1.82e-1)" 0.1 0.2 0.1 0.0 0.1 0.1 0.3 0.1 0.3 0.6 0.0 0.2 0.0 0.2 0.3 0.4 0.4 0.1 0.1 0.1 0.0 0.6 0.3 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 1.0 0.1 131.4 0.4 0.0 0.1 0.2 0.2 0.0 0.0 0.1 0.5 0.7 0.0 0.0 0.6 0.0 0.0 0.2 0.3 0.0 0.0 0.5 0.0 0.8 0.0 0.2 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.3 0.3 0.0 0.7 0.6 0.2 0.2 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.2 0.0 0.1 0.4 0.0 0.2 0.0 0.4 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.8 0.0 0.4 0.1 0.0 0.3 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 2.0 0.0 1.2 33.1 2.1 0.5 0.7 0.0 0.0 0.0 41.7 0.0 0.1 0.7 0.0 0.3 1.1 1.4 1.5 3.9 0.0 0.0 0.3 0.2 0.3 0.3 0.0 1.8 0.0 0.2 0.0 0.4 0.1 30.3 0.2 0.0 0.0 0.3 0.0 0.3 0.6 0.1 0.0 0.0 0.0 45.0 0.0 0.5 0.0 0.6 0.3 1.9 0.0 4.3 0.2 0.0 0.0 1357.8 0.0 3.3 0.3 0.6 0.4 0.8 0.0 0.0 0.0 4.3 0.5 1.1 NR2F1 "COUP-TFI, COUPTF1, EAR-3, ERBAL3, SVP44, TCFCOUP1, TFCOUP1" ENSG00000175745 "Nuclear receptor subfamily 2 group F member 1" P10589 5 93583222-93594611 "Disease related genes, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding, Receptor, Repressor" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 294.1;Hepatic stellate cells: 171.4;Leydig cells: 93.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 232.4;AN3-CA: 92.9;HHSteC: 174.1;hTERT-RPE1: 155.1;PC-3: 194.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB019281, HPA058974" Approved Nucleoplasm,Cytosol NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 36: Stromal cells - Cell proliferation" Nucleoplasm Cytosol "CAB019281: , HPA058974: AB_2732629" "unprognostic (8.07e-2)" "unprognostic (1.06e-2)" "unprognostic (3.86e-2)" "unprognostic (2.26e-1)" "unprognostic (4.75e-1)" "unprognostic (7.68e-3)" "unprognostic (3.18e-3)" "unprognostic (3.07e-2)" "unprognostic (2.21e-1)" "unprognostic (2.71e-3)" "unprognostic (5.24e-3)" "unprognostic (2.37e-1)" "prognostic unfavorable (3.47e-4)" "unprognostic (1.32e-2)" "unprognostic (1.61e-1)" "unprognostic (9.28e-2)" "prognostic unfavorable (1.47e-4)" 42.2 40.3 41.8 5.0 39.0 0.2 20.4 32.9 50.7 65.1 12.8 11.3 2.6 29.4 25.2 10.4 77.9 34.3 16.1 44.7 25.6 32.8 13.0 44.4 8.3 31.6 41.1 62.7 7.6 1.6 21.6 52.6 23.8 44.9 3.0 8.7 6.9 40.3 0.3 2.0 7.4 11.8 31.5 7.2 28.8 3.8 42.4 2.1 16.9 3.6 3.8 49.1 40.6 30.8 20.1 9.5 232.4 92.9 48.3 14.8 11.0 11.6 4.7 6.9 7.1 1.3 3.6 0.1 0.7 4.7 2.8 5.0 5.7 0.4 3.0 24.7 45.2 9.2 61.9 15.1 174.1 1.9 0.9 69.7 0.1 3.3 1.3 155.1 26.3 0.1 0.1 0.1 21.4 0.1 0.0 2.7 0.1 1.4 194.2 2.8 1.9 0.1 1.4 0.8 23.9 48.4 5.2 0.0 0.6 4.0 1.9 3.7 26.7 39.3 1.8 20.6 29.4 0.0 0.0 0.1 64.2 0.8 17.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 41.8 39.0 32.9 50.7 44.7 25.6 31.6 41.1 23.8 31.5 42.4 30.8 16.1 0.0 1.7 68.2 1.5 1.3 0.2 0.4 1.8 32.8 3.8 2.4 37.3 1.5 3.5 14.7 54.2 0.6 0.0 0.2 7.9 4.0 3.8 10.1 294.1 70.1 0.0 0.0 23.3 1.6 0.6 69.1 0.5 5.7 0.0 29.7 171.4 5.0 1.3 0.0 47.1 0.0 0.0 15.8 0.4 5.9 93.5 1.9 0.0 59.0 0.0 69.0 0.0 13.0 1.7 3.6 0.0 10.5 0.0 0.5 0.1 37.3 10.8 3.7 13.1 2.9 51.6 4.8 4.4 2.8 0.6 1.1 2.2 11.8 0.0 0.6 NR4A2 "HZF-3, NOT, NURR1, RNR1, TINUR" ENSG00000153234 "Nuclear receptor subfamily 4 group A member 2" P43354 2 156324437-156342348 "Cancer-related genes, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "DNA-binding, Receptor" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 129.3;bone marrow: 130.8;ovary: 129.2" "Cell type enhanced" "Detected in many" "B-cells: 511.7;dendritic cells: 410.4;Langerhans cells: 782.3;Macrophages: 577.5;T-cells: 465.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "neutrophil: 6.5" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HeLa: 16.0;HMC-1: 10.9;SK-MEL-30: 8.1;U-266/70: 14.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000543, CAB010481" Uncertain Supported "Nuclear speckles" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 20: HeLa - Mitochondria" "Cluster 41: Macrophages - Immune response" "Nuclear speckles" "CAB010481: AB_2298676, HPA000543: AB_1854631" "unprognostic (4.26e-2)" "unprognostic (2.14e-1)" "unprognostic (3.42e-2)" "unprognostic (4.10e-2)" "unprognostic (3.04e-2)" "unprognostic (5.26e-2)" "unprognostic (2.30e-1)" "unprognostic (6.14e-2)" "unprognostic (8.63e-2)" "unprognostic (3.88e-2)" "unprognostic (1.60e-2)" "unprognostic (2.89e-1)" "unprognostic (2.39e-2)" "unprognostic (3.58e-2)" "unprognostic (3.43e-1)" "unprognostic (9.29e-3)" "unprognostic (1.11e-1)" 40.0 129.3 4.3 24.5 44.1 130.8 15.6 36.2 8.8 18.3 5.9 9.5 2.9 15.0 1.7 11.4 28.2 32.7 36.6 15.1 3.6 19.2 20.2 18.8 6.3 3.2 9.2 129.2 9.2 8.8 54.0 5.2 2.8 25.6 18.7 5.3 19.2 15.5 11.6 12.8 7.8 14.5 0.9 4.6 19.9 5.6 2.5 9.7 15.2 7.8 1.4 50.9 14.0 6.4 0.9 1.3 0.5 1.8 3.2 0.7 0.9 1.1 5.5 0.4 1.3 0.0 3.3 0.0 1.2 0.4 0.4 1.6 2.6 0.7 0.4 1.3 1.4 1.0 16.0 0.0 0.6 0.7 10.9 0.6 1.2 0.4 0.4 2.1 0.3 0.0 1.6 1.0 1.1 1.9 0.0 0.8 2.1 1.5 0.8 0.2 0.7 3.3 0.6 0.8 2.7 0.1 2.6 4.1 8.1 0.3 0.2 1.0 0.7 2.9 0.8 0.7 0.4 14.2 1.8 0.0 5.3 1.0 7.0 1.9 1.7 2.4 1.0 0.3 0.5 0.4 0.3 0.5 1.9 0.3 0.5 0.2 6.5 0.0 0.7 0.0 0.4 0.5 4.3 44.1 36.2 8.8 15.1 3.6 3.2 9.2 2.8 0.9 2.5 6.4 70.7 25.6 124.7 7.8 511.7 218.6 25.8 87.5 298.7 11.8 120.8 160.1 11.9 17.2 58.3 71.7 50.1 4.7 410.4 35.0 0.0 13.1 36.7 209.6 33.9 111.9 206.4 12.0 5.8 9.1 6.5 164.9 103.9 349.7 349.3 4.3 45.0 6.8 125.1 0.0 0.8 95.4 42.7 161.1 782.3 37.2 4.1 577.5 241.9 5.6 7.9 1.6 3.1 4.0 2.3 11.7 41.9 0.7 203.5 49.1 25.9 0.4 54.6 33.4 13.1 63.0 169.8 1.8 3.3 230.2 213.7 9.9 465.1 34.4 57.5 29.5 NRL "D14S46E, NRL-MAF, RP27" ENSG00000129535 "Neural retina leucine zipper" P54845 14 24078662-24115010 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Sensory transduction, Transcription, Transcription regulation, Vision" "Activator, Developmental protein, DNA-binding" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 75 "retina: 317.3" "Cell type enriched" "Detected in many" 5 "Rod photoreceptor cells: 3720.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "SuSa: 4.8" "Low region specificity" "Detected in some" "Not detected" "Not detected" "CAB026066, HPA064599" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 79: Retina - Phototransduction" "Cluster 29: U-266 - Adaptive immune response" "Cluster 46: Photoreceptor cells - Phototransduction" Nucleoplasm Cytosol "CAB026066: , HPA064599: AB_2685295" "unprognostic (2.71e-2)" "unprognostic (8.17e-4)" "unprognostic (4.60e-2)" "unprognostic (1.80e-1)" "unprognostic (7.23e-2)" "unprognostic (1.99e-2)" "unprognostic (5.29e-2)" "unprognostic (1.88e-5)" "unprognostic (3.59e-2)" "unprognostic (7.84e-3)" "unprognostic (1.75e-3)" "unprognostic (3.49e-2)" "unprognostic (2.38e-5)" "unprognostic (2.56e-2)" "unprognostic (1.10e-1)" "unprognostic (1.73e-1)" "unprognostic (1.35e-3)" 0.8 2.5 1.7 0.5 1.5 0.5 1.0 2.3 2.2 1.1 0.6 0.9 1.1 1.1 0.7 1.1 1.0 0.9 2.2 1.5 1.5 3.1 3.6 1.0 1.0 2.3 1.8 1.2 1.7 1.9 2.4 0.3 1.7 1.5 0.3 317.3 1.0 0.7 2.5 0.7 1.3 0.3 1.7 2.1 1.2 4.2 1.6 1.2 2.7 1.4 0.7 1.1 0.8 1.7 0.3 1.2 1.6 1.6 0.3 0.2 0.4 0.3 0.3 0.5 0.3 0.7 0.5 1.2 0.4 0.5 1.0 0.5 0.6 0.3 0.2 0.6 0.5 0.7 0.6 2.2 0.6 1.4 1.6 0.4 0.5 0.2 0.7 0.7 0.5 2.2 0.7 1.2 0.3 0.9 1.2 0.6 1.8 1.8 0.9 1.2 1.5 0.0 0.4 1.3 1.7 1.2 0.8 0.7 0.8 4.8 0.9 1.5 0.4 1.1 0.5 0.1 0.7 3.6 1.9 1.5 0.3 0.9 1.1 0.2 0.3 1.3 0.2 0.4 0.1 1.0 0.2 0.4 0.3 0.7 0.8 0.6 0.1 0.5 0.3 0.4 0.2 0.3 1.7 1.5 2.3 2.2 1.5 1.5 2.3 1.8 1.7 1.7 1.6 1.7 1.4 0.0 0.5 5.5 6.2 0.8 1.6 0.1 1.2 434.4 2.0 1.9 2.1 0.0 0.7 7.3 431.6 1.4 3.2 1.5 13.7 0.6 2.7 1.3 0.7 24.1 1.8 3.2 1.8 1.1 0.9 0.7 2.6 1.0 0.0 0.7 0.7 3.3 2.0 250.7 2.6 1.7 0.0 1.3 0.4 4.2 1.2 1.4 1.8 0.0 1.1 636.4 5.2 2.0 4.4 0.3 5.3 1.9 1.7 2.0 5.6 6.7 0.1 3720.7 0.0 1.2 0.7 9.7 4.3 2.2 0.4 2.5 2.6 2.3 1.0 2.1 NT5C2 "cN-II, GMP, NT5B, PNT5, SPG45, SPG65" ENSG00000076685 "5'-nucleotidase, cytosolic II" P49902 10 103087185-103277605 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Nucleotide metabolism" "Allosteric enzyme, Hydrolase" "Cancer-related genes, Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 141.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003751 Approved NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 22: Epithelial cell types - Mixed function" "HPA003751: AB_1854664" "unprognostic (8.18e-2)" "unprognostic (1.98e-1)" "unprognostic (2.55e-2)" "unprognostic (2.46e-1)" "unprognostic (5.54e-2)" "unprognostic (4.87e-3)" "unprognostic (2.24e-2)" "unprognostic (1.72e-1)" "unprognostic (6.41e-2)" "unprognostic (9.59e-2)" "unprognostic (2.93e-3)" "unprognostic (6.20e-2)" "unprognostic (3.26e-2)" "unprognostic (3.70e-2)" "unprognostic (6.40e-2)" "unprognostic (3.43e-1)" "unprognostic (1.50e-1)" 24.6 27.0 25.0 19.0 27.2 29.7 23.0 27.3 28.5 37.6 36.8 27.3 9.9 18.8 17.3 67.1 26.5 16.4 28.5 25.2 28.8 32.5 27.8 30.8 18.3 26.9 29.5 32.4 22.0 21.7 34.0 17.9 27.2 32.4 16.7 47.3 46.4 18.4 51.6 19.9 20.4 13.4 26.4 32.8 22.3 30.8 27.2 28.6 55.4 18.1 24.5 33.3 42.7 28.6 148.4 52.5 32.6 67.5 27.2 33.2 18.2 66.0 64.7 29.9 32.4 34.6 91.7 49.2 47.7 45.6 27.6 62.8 23.4 33.8 38.3 40.3 21.6 38.7 21.1 39.6 48.5 64.2 21.0 50.4 34.1 28.0 24.8 57.5 25.6 19.4 29.4 36.4 54.5 73.8 53.7 64.6 34.6 43.2 68.6 102.6 30.0 19.6 43.3 72.5 10.0 24.9 35.8 25.9 50.3 33.7 39.2 38.1 30.5 20.5 24.8 39.7 51.7 32.9 71.6 85.5 23.9 64.6 7.8 29.5 16.5 31.3 10.0 18.8 10.3 8.9 8.4 8.7 14.7 5.2 6.7 8.0 27.4 14.4 23.0 9.6 9.3 10.5 25.0 27.2 27.3 28.5 25.2 28.8 26.9 29.5 27.2 26.4 27.2 28.6 16.2 83.3 34.9 141.7 17.2 7.4 29.0 26.9 5.7 24.4 13.9 13.6 2.6 18.6 60.4 27.6 45.9 19.4 23.3 48.7 11.7 28.5 103.7 29.5 17.1 19.8 11.5 12.4 79.8 26.0 11.7 17.5 25.5 46.2 8.8 18.2 13.9 17.4 19.9 47.1 83.6 17.6 18.3 29.8 14.2 61.9 24.8 27.1 26.6 78.7 25.9 85.5 16.5 70.4 107.5 57.9 23.1 13.5 21.0 35.7 11.7 15.3 44.1 59.1 32.9 22.9 21.7 25.3 20.5 22.9 7.5 35.0 16.6 15.8 18.0 80.5 NTF4 "GLC1O, NT-4/5, NTF5" ENSG00000225950 "Neurotrophin 4" P34130 19 49061066-49065054 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted secreted proteins, RAS pathway related proteins" "Growth factor" "Cancer-related genes, Glaucoma" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "prostate: 20.1;skeletal muscle: 17.1;skin 1: 31.1" "Cell type enhanced" "Detected in some" "Basal prostatic cells: 35.6;Basal respiratory cells: 24.0;Basal squamous epithelial cells: 15.4;Breast myoepithelial cells: 24.3;Club cells: 9.5;Cytotrophoblasts: 13.6;Urothelial cells: 11.9" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CAPAN-2: 13.8;HaCaT: 31.1;HBEC3-KT: 11.7;hTCEpi: 50.4" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA049376 Approved "Golgi apparatus" "Secreted in other tissues" NA NA "Cluster 31: Skin - Epidermis development" "Cluster 30: Epithelial cell lines - Translation" "Cluster 22: Epithelial cell types - Mixed function" "Golgi apparatus" "HPA049376: AB_2680735" "unprognostic (4.15e-2)" "unprognostic (1.07e-1)" "unprognostic (9.27e-4)" "unprognostic (1.76e-4)" "unprognostic (2.36e-1)" "unprognostic (1.02e-2)" "unprognostic (1.60e-1)" "unprognostic (2.73e-2)" "unprognostic (4.87e-3)" "unprognostic (3.90e-4)" "unprognostic (2.97e-1)" "unprognostic (1.40e-3)" "unprognostic (3.71e-2)" "unprognostic (2.49e-1)" "unprognostic (1.89e-2)" "unprognostic (2.46e-3)" 0.1 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.1 4.3 0.7 0.0 0.0 0.1 3.7 10.8 2.5 0.0 1.0 0.1 0.0 0.1 0.0 3.5 0.0 0.1 0.2 0.2 0.0 0.0 1.6 3.2 0.1 20.1 0.0 0.0 8.2 7.1 17.1 31.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 3.9 1.5 2.5 1.1 6.5 9.6 0.1 3.9 0.2 0.3 2.1 0.0 0.0 9.3 0.0 0.0 0.1 0.0 3.4 13.8 0.0 3.5 0.0 0.5 31.1 0.1 11.7 0.1 0.0 0.5 0.0 0.4 0.0 0.0 0.0 0.1 0.0 50.4 0.0 1.6 3.1 0.0 0.1 0.0 0.2 0.4 1.2 0.0 0.0 0.0 0.1 0.3 0.0 0.1 0.0 0.0 8.8 0.0 0.1 0.7 0.1 0.0 4.3 8.0 0.1 0.2 1.8 3.5 0.2 9.5 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.2 0.1 0.0 0.0 0.1 0.1 3.2 0.0 0.0 0.0 7.0 35.6 24.0 15.4 0.0 3.4 24.3 0.4 0.0 9.5 0.0 0.0 13.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 2.5 0.3 0.0 0.0 0.0 0.9 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.5 0.0 0.0 5.7 0.0 0.0 0.0 0.9 0.0 1.3 1.7 3.1 2.7 0.3 0.1 0.0 11.9 NTN1 NTN1L ENSG00000065320 "Netrin 1" O95631 17 9021510-9244000 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" Apoptosis "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 37.1;heart muscle: 59.4" "Cell type enriched" "Detected in many" 4 "Oligodendrocyte precursor cells: 137.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 27.5;T-47d: 16.6;U-2 OS: 14.4;U-251 MG: 22.1;WM-115: 12.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056419 Approved Approved "Nucleoplasm,Actin filaments,Cytosol" "Secreted to extracellular matrix" NA NA 110000 "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 28: BEWO - Transcription regulation" "Cluster 68: Oligodendrocytes - Mixed function" Cytosol "Nucleoplasm, Actin filaments" "HPA056419: AB_2683124" "unprognostic (2.72e-1)" "unprognostic (2.59e-2)" "unprognostic (7.12e-2)" "unprognostic (5.25e-2)" "unprognostic (2.51e-1)" "unprognostic (9.33e-3)" "unprognostic (9.42e-2)" "unprognostic (2.20e-1)" "unprognostic (1.63e-1)" "unprognostic (1.33e-2)" "unprognostic (1.89e-1)" "unprognostic (1.15e-1)" "unprognostic (2.49e-2)" "unprognostic (2.20e-2)" "unprognostic (2.60e-1)" "unprognostic (6.07e-3)" "unprognostic (8.31e-3)" 6.4 0.5 4.5 3.6 6.4 0.1 5.3 10.1 4.9 9.3 2.8 14.7 6.7 9.6 3.5 18.9 10.3 7.3 59.4 3.8 7.0 2.0 6.9 4.3 0.2 12.7 37.1 0.9 2.3 4.3 3.0 0.9 14.4 3.9 3.9 0.4 10.9 2.0 2.1 8.1 10.5 6.0 13.8 0.1 17.5 3.1 10.1 2.9 2.0 2.6 2.1 10.2 5.4 8.8 0.1 0.0 1.3 4.6 4.2 0.1 27.5 0.3 0.4 0.3 0.5 0.1 5.7 0.0 6.2 0.0 9.0 0.1 1.2 0.9 0.0 6.4 10.4 1.4 0.0 0.0 0.1 0.5 0.1 0.1 2.1 0.8 0.0 0.0 0.0 1.0 0.0 0.0 0.1 5.6 0.1 0.6 1.8 0.0 0.0 3.4 4.8 0.0 0.0 0.3 0.0 0.0 0.1 4.7 1.1 4.5 16.6 0.3 0.0 6.7 14.4 0.0 22.1 0.0 0.0 0.0 0.0 0.0 12.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.5 6.4 10.1 4.9 3.8 7.0 12.7 37.1 14.4 13.8 10.1 8.8 0.7 0.0 0.0 10.7 0.3 3.3 6.6 21.8 9.6 2.9 4.7 4.4 28.1 0.0 23.9 1.8 0.0 0.3 0.2 0.5 0.0 3.1 9.3 5.8 2.0 3.1 0.0 0.0 4.8 1.7 1.2 9.7 1.1 7.9 0.0 0.0 2.2 12.4 0.1 0.0 7.1 1.4 24.4 0.6 5.9 4.6 0.3 0.1 1.8 9.4 0.6 0.3 0.0 137.2 1.0 1.4 0.1 0.0 0.0 4.0 0.7 0.2 11.1 0.2 0.0 3.9 6.8 1.6 2.0 12.7 2.8 0.5 0.5 0.0 0.6 3.5 NTRK1 "MTC, TRK, TRKA" ENSG00000198400 "Neurotrophic receptor tyrosine kinase 1" P04629 1 156815640-156881850 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Differentiation, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "adrenal gland: 7.0;brain: 21.7" "Group enriched" "Detected in some" 10 "Bipolar cells: 22.8;granulocytes: 55.9;Horizontal cells: 57.2" "Cancer enhanced" "Detected in some" "glioma: 1.3" "Group enriched" "Detected in many" 6 "cerebral cortex: 7.6;medulla oblongata: 19.8;pons: 21.7" "Immune cell enriched" "Detected in single" 116 "basophil: 94.5" "Lineage enriched" "Detected in single" 768 "granulocytes: 94.5" "Cell line enriched" "Detected in some" 4 "HMC-1: 82.1" "Region enhanced" "Detected in many" "basal ganglia: 8.4" "Region enriched" "Detected in single" 6 "basal ganglia: 4.1" "CAB004606, HPA035799, HPA076570" Approved Approved Vesicles,Cytosol NA NA 79000 "Cluster 38: Basophils - Unknown function" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 3: HMC-1 - Innate immune response" "Cluster 62: Horizontal cells - Visual perception" "Vesicles, Cytosol" "CAB004606: AB_628397, HPA035799: AB_2674788, HPA076570: " "unprognostic (5.89e-3)" "unprognostic (7.56e-2)" "unprognostic (2.74e-2)" "unprognostic (5.99e-3)" "unprognostic (7.26e-2)" "unprognostic (1.43e-3)" "unprognostic (1.56e-1)" "unprognostic (7.42e-3)" "unprognostic (7.63e-2)" "unprognostic (1.35e-1)" "unprognostic (6.73e-2)" "unprognostic (2.29e-2)" "unprognostic (3.18e-11)" "unprognostic (2.18e-3)" "unprognostic (3.79e-2)" "unprognostic (1.07e-1)" "unprognostic (4.89e-1)" 0.8 7.0 0.7 0.4 1.8 0.7 0.2 1.8 7.6 0.7 0.7 0.8 0.5 1.0 0.0 0.1 0.5 0.4 1.0 0.3 2.8 3.0 0.0 0.5 0.1 19.8 1.5 0.1 0.2 0.0 0.7 0.2 21.7 1.4 0.0 1.9 0.5 0.3 0.4 0.1 0.3 0.6 0.2 0.1 0.5 1.6 0.4 0.3 0.2 0.2 0.0 0.3 0.5 0.6 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.2 0.1 0.0 0.0 0.0 11.9 0.0 14.0 0.0 0.0 0.0 0.0 82.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 4.4 1.6 0.0 0.2 0.0 2.4 0.2 0.0 1.5 2.5 0.0 0.2 0.0 0.5 1.5 18.2 0.0 0.1 0.0 0.3 0.0 0.1 0.3 0.0 1.1 0.0 0.0 3.5 0.6 0.0 0.0 0.0 0.1 94.5 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.2 0.7 1.8 1.8 7.6 0.3 2.8 19.8 1.5 21.7 0.2 0.4 0.6 0.1 0.0 1.3 0.3 0.0 0.0 0.0 0.0 0.0 22.8 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.6 0.2 0.0 4.2 0.7 0.0 0.0 4.3 0.0 0.1 55.9 0.0 0.0 0.0 0.1 57.2 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 2.8 0.0 0.5 0.0 0.5 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.9 3.2 2.7 0.0 0.1 0.0 1.0 0.1 0.0 0.0 NTRK2 TRKB ENSG00000148053 "Neurotrophic receptor tyrosine kinase 2" Q16620 9 84668551-85027054 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, RAS pathway related proteins" "Differentiation, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, Epilepsy, FDA approved drug targets, Obesity" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 230.0;thyroid gland: 116.9" "Cell type enhanced" "Detected in many" "Astrocytes: 1144.3;Excitatory neurons: 750.1;Inhibitory neurons: 877.7;Oligodendrocyte precursor cells: 557.9" "Group enriched" "Detected in many" 5 "glioma: 31.6;head and neck cancer: 8.0;lung cancer: 9.8;thyroid cancer: 26.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 8.7;HaCaT: 3.0;RPTEC TERT1: 9.7;SH-SY5Y: 11.2;SuSa: 4.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007637, CAB010346, HPA074873" Enhanced Supported "Plasma membrane" NA NA 20000000 "Cluster 73: Brain - Neuropeptide signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane" "CAB010346: AB_2155274, HPA007637: AB_1080385, HPA074873: " "unprognostic (2.75e-3)" "unprognostic (3.48e-2)" "unprognostic (1.82e-2)" "unprognostic (3.26e-1)" "unprognostic (9.26e-2)" "unprognostic (2.56e-2)" "unprognostic (1.29e-2)" "unprognostic (9.16e-2)" "unprognostic (6.13e-2)" "unprognostic (1.05e-1)" "unprognostic (4.25e-2)" "unprognostic (2.18e-2)" "unprognostic (2.66e-2)" "unprognostic (1.20e-2)" "unprognostic (1.21e-2)" "unprognostic (1.31e-1)" "unprognostic (1.39e-3)" 40.5 2.7 201.9 1.7 177.8 0.1 62.2 133.3 190.6 9.8 69.8 5.9 0.4 3.9 3.9 8.2 5.6 33.3 15.2 173.3 230.0 20.4 1.8 10.0 3.1 119.4 218.9 9.7 34.3 2.5 10.1 1.8 151.7 4.7 3.6 41.2 14.4 19.1 2.9 11.6 1.6 3.3 116.6 10.9 1.9 2.4 222.1 4.0 116.9 13.8 4.3 4.9 12.0 117.7 0.0 0.0 8.7 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 1.4 0.0 0.2 0.0 0.0 3.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 9.7 0.7 0.7 11.2 0.0 0.0 0.0 4.9 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.1 0.0 0.3 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 201.9 177.8 133.3 190.6 173.3 230.0 119.4 218.9 151.7 116.6 222.1 117.7 17.4 0.0 0.5 1144.3 0.7 56.6 1.0 1.8 93.9 30.3 144.1 116.8 11.4 0.0 0.2 9.2 6.2 0.0 1.0 8.7 27.4 36.1 1.8 1.2 0.4 8.0 0.0 0.0 750.1 0.7 0.1 76.6 0.0 2.3 0.0 0.1 5.0 0.0 0.2 242.3 877.7 0.7 0.0 0.0 14.2 3.6 104.1 1.4 17.8 65.6 0.6 241.0 0.0 557.9 109.5 0.5 7.0 48.2 0.3 0.9 0.0 7.1 1.7 12.2 124.9 9.9 114.4 0.8 2.3 5.2 24.6 0.0 3.3 0.2 7.2 0.9 NUP62 "DKFZp547L134, FLJ20822, FLJ43869, IBSN, MGC841, p62, SNDI" ENSG00000213024 "Nucleoporin 62" P37198 19 49906825-49929763 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Host-virus interaction, mRNA transport, Protein transport, Translocation, Transport" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Langerhans cells: 119.2;Late spermatids: 315.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005435, CAB020724" Supported Supported "Nucleoplasm,Nuclear membrane" NA Yes 31000 "Cluster 27: Non-specific - Gene expression" "Cluster 23: Testis - Cell cycle regulation" "Cluster 16: U-266 - Nucleosome" "Cluster 25: Spermatids - Spermatogenesis" "Nuclear membrane" Nucleoplasm "CAB020724: , HPA005435: AB_1079510" "unprognostic (2.26e-1)" "unprognostic (4.06e-2)" "unprognostic (9.92e-2)" "unprognostic (9.68e-2)" "unprognostic (7.83e-2)" "unprognostic (1.12e-2)" "prognostic unfavorable (2.50e-7)" "unprognostic (2.76e-2)" "unprognostic (3.61e-3)" "unprognostic (3.97e-2)" "unprognostic (4.06e-2)" "unprognostic (2.03e-2)" "prognostic unfavorable (5.71e-12)" "unprognostic (3.89e-3)" "unprognostic (3.62e-1)" "unprognostic (3.96e-1)" "unprognostic (3.27e-3)" 19.9 29.4 14.2 37.3 13.2 27.1 18.9 18.4 15.9 22.5 14.0 22.5 23.7 27.6 11.0 25.0 24.8 18.4 20.4 13.9 15.7 18.5 31.7 19.4 38.3 15.5 14.2 29.8 21.0 18.0 22.8 22.4 15.8 19.9 21.1 11.1 21.8 17.5 33.7 23.4 24.3 27.7 13.6 29.8 19.4 50.4 14.7 41.9 16.3 24.5 37.7 24.6 20.1 16.9 126.7 115.5 88.8 74.0 26.0 30.0 79.7 92.8 65.8 99.3 98.8 79.8 71.9 141.2 51.7 60.8 65.9 73.6 108.3 62.1 96.1 211.6 112.0 109.8 59.4 72.6 30.9 108.8 106.8 28.6 44.8 62.0 54.8 44.1 71.5 82.7 138.6 135.5 69.2 59.7 196.7 83.6 82.0 117.4 102.8 170.3 99.9 120.3 46.9 93.7 96.2 68.8 88.2 103.8 46.3 63.8 78.8 51.5 53.0 150.2 85.3 49.1 155.4 96.3 295.9 132.5 62.2 90.1 113.9 12.3 33.4 6.7 17.7 34.7 24.1 15.1 17.6 19.6 33.1 14.9 11.9 15.4 5.2 22.0 20.1 29.0 17.2 22.1 14.2 13.2 18.4 15.9 13.9 15.7 15.5 14.2 15.8 13.6 14.7 16.9 16.8 25.6 22.4 0.0 28.4 34.2 16.5 16.0 21.1 11.4 23.7 26.0 15.4 21.5 18.3 9.2 6.2 37.0 24.4 24.9 9.8 23.7 113.5 19.2 23.9 27.7 21.6 39.1 0.0 16.3 48.4 19.5 20.4 25.6 23.4 30.4 30.4 13.3 49.5 63.9 0.0 27.0 16.2 36.1 119.2 315.1 24.8 41.5 21.4 0.0 77.1 19.1 22.6 0.0 0.0 22.9 22.8 23.0 23.3 24.1 20.6 16.1 19.2 16.3 19.7 18.0 16.0 71.0 39.3 20.0 32.0 21.8 24.4 17.2 33.4 16.6 NYX "CLRP, CSNB1, CSNB1A, CSNB4" ENSG00000188937 Nyctalopin Q9GZU5 X 41447343-41475710 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Sensory transduction, Vision" "Congenital stationary night blindness, Disease variant" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Cell type enriched" "Detected in some" 7 "Bipolar cells: 13.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 4 "HDLM-2: 2.5" "Not detected" "Not detected" "Not detected" "Not detected" "Intracellular and membrane" NA NA "Cluster 44: HDLM-2 - Immune response" "Cluster 56: Bipolar cells - Visual perception" "unprognostic (3.27e-2)" "unprognostic (6.72e-2)" "unprognostic (4.21e-2)" "unprognostic (4.10e-4)" "unprognostic (1.83e-1)" "unprognostic (3.96e-2)" "unprognostic (1.80e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 13.2 0.0 0.0 0.5 0.0 0.0 1.8 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 1.5 0.0 0.6 0.0 0.0 0.0 0.5 1.7 0.0 0.0 0.3 0.0 0.1 0.0 0.0 OCLN PPP1R115 ENSG00000197822 Occludin Q16625 5 69492292-69558104 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "thyroid gland: 31.4" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 109.0;Glandular and luminal cells: 119.7;Urothelial cells: 224.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 2.7" "Lineage enriched" "Detected in single" 5 "granulocytes: 2.7" "Cell line enhanced" "Detected in many" "A-431: 23.3;CAPAN-2: 39.8;HaCaT: 33.4;RPTEC TERT1: 25.7;SK-BR-3: 27.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005933, CAB013075, CAB068212, CAB068213, CAB068214" Enhanced Supported "Plasma membrane,Cell Junctions" "Intracellular and membrane" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 29: Non-specific - Vesicular transport" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 22: Epithelial cell types - Mixed function" "Plasma membrane, Cell Junctions" "CAB013075: AB_2533101, CAB068212: AB_2665711, CAB068213: AB_2665712, CAB068214: AB_2665713, HPA005933: AB_1079520" "unprognostic (2.28e-1)" "unprognostic (1.88e-1)" "unprognostic (2.50e-2)" "unprognostic (9.94e-2)" "unprognostic (3.65e-1)" "unprognostic (1.39e-1)" "unprognostic (2.24e-1)" "unprognostic (1.08e-2)" "unprognostic (8.25e-2)" "unprognostic (8.20e-2)" "unprognostic (2.58e-2)" "unprognostic (3.48e-1)" "prognostic favorable (6.59e-11)" "unprognostic (2.83e-1)" "unprognostic (4.01e-1)" "unprognostic (1.33e-1)" "unprognostic (3.35e-1)" 1.2 0.7 6.2 1.6 6.5 1.8 7.8 7.2 6.7 6.8 22.2 11.0 10.3 2.1 4.0 11.6 7.5 8.5 1.5 5.9 5.4 11.0 18.8 15.1 0.6 9.3 7.7 2.3 20.2 8.3 3.4 3.9 8.3 3.5 11.2 2.3 6.7 4.6 0.6 11.3 10.0 0.6 5.4 2.1 15.2 2.4 6.5 0.9 31.4 0.6 2.8 5.0 7.9 7.4 23.3 4.5 0.6 0.9 0.6 0.9 15.1 0.3 1.6 2.5 3.3 20.7 39.8 0.5 5.9 1.1 8.3 33.4 7.2 4.3 7.8 0.3 12.2 2.4 1.1 9.8 0.3 1.2 2.5 0.1 6.4 4.1 1.0 1.6 1.4 3.1 0.1 0.4 0.1 22.4 1.5 1.2 3.1 8.0 2.1 0.2 6.0 1.1 25.7 22.2 2.7 2.8 0.3 27.2 0.9 5.0 14.7 4.0 1.2 0.4 7.7 1.8 2.7 0.5 0.4 0.3 0.3 0.3 0.6 1.0 0.2 0.5 0.2 0.1 0.2 0.3 0.2 0.1 0.1 0.4 0.2 0.2 2.7 0.5 0.1 0.4 0.1 0.1 6.2 6.5 7.2 6.7 5.9 5.4 9.3 7.7 8.3 5.4 6.5 7.4 4.8 109.0 67.3 1.6 3.2 3.7 60.8 7.6 1.8 5.7 49.7 16.9 1.4 64.3 51.0 25.8 14.6 30.3 3.6 94.1 9.8 65.6 1.9 78.5 12.1 10.7 26.3 2.5 1.3 61.6 2.5 5.8 46.4 119.7 2.5 6.5 18.2 48.3 3.0 6.7 1.1 45.1 16.2 12.9 1.2 1.6 3.1 2.4 1.8 16.9 3.9 2.8 1.0 0.5 1.5 64.6 61.8 1.5 1.1 101.5 42.3 10.5 63.0 6.3 13.1 3.3 4.4 4.7 8.2 29.5 15.5 16.4 4.3 0.7 47.9 224.0 OFD1 "71-7A, CXorf5, JBTS10, RP23" ENSG00000046651 "OFD1 centriole and centriolar satellite protein" O75665 X 13734745-13769357 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cilium biogenesis/degradation" "Ciliopathy, Disease variant, Joubert syndrome, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 4 "plasmacytoid DC: 64.2" "Lineage enriched" "Detected in all" 4 "dendritic cells: 64.2" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031102, HPA031103, HPA031104" Approved Supported Microtubules NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 25: RPMI-8226 - Immune response" "Cluster 44: Endometrium - Transcription" Microtubules "HPA031102: AB_10670836, HPA031103: AB_10602188, HPA031104: AB_10669655" "unprognostic (3.10e-3)" "prognostic favorable (9.62e-4)" "unprognostic (2.83e-1)" "unprognostic (2.68e-2)" "unprognostic (1.10e-1)" "unprognostic (7.42e-3)" "unprognostic (2.20e-3)" "unprognostic (3.03e-3)" "unprognostic (1.82e-2)" "unprognostic (1.43e-3)" "unprognostic (2.82e-1)" "unprognostic (1.50e-2)" "prognostic unfavorable (1.63e-4)" "unprognostic (3.32e-2)" "unprognostic (3.90e-2)" "unprognostic (1.04e-2)" "prognostic favorable (2.76e-7)" 5.8 5.9 8.3 11.7 8.7 15.6 14.6 10.8 9.8 11.2 10.1 9.4 10.2 10.5 11.5 9.9 9.6 7.3 5.9 8.2 9.4 9.6 7.2 9.2 19.1 9.7 8.3 11.2 11.2 15.3 10.9 5.3 8.9 11.7 8.2 11.2 15.6 6.5 5.2 11.8 12.8 7.6 8.2 13.9 12.2 9.9 8.4 10.1 12.9 4.1 16.8 8.5 10.4 10.0 16.0 7.1 10.3 18.4 8.4 13.0 7.7 4.9 11.3 5.7 7.3 12.8 17.7 23.2 12.5 5.9 10.6 15.3 7.5 13.7 9.2 11.6 18.9 10.8 22.3 10.8 6.4 14.4 19.1 10.4 9.1 12.9 12.7 10.6 6.4 4.2 16.5 20.4 6.4 12.6 9.9 17.3 10.8 5.8 10.2 24.9 11.9 46.6 8.9 13.5 10.5 16.6 23.2 18.5 11.6 22.7 17.5 13.0 5.8 10.0 5.2 12.1 6.3 15.1 15.1 26.9 8.3 6.4 8.3 4.3 1.7 6.2 11.6 2.2 13.4 13.7 10.1 14.2 3.8 15.4 8.3 12.5 4.7 14.1 3.1 64.2 8.6 4.4 8.3 8.7 10.8 9.8 8.2 9.4 9.7 8.3 8.9 8.2 8.4 10.0 40.2 70.5 64.1 60.4 90.8 22.4 89.3 51.8 38.1 47.9 65.9 64.1 17.8 35.8 66.7 31.3 89.6 34.5 219.8 82.3 7.9 60.2 178.6 232.2 33.0 39.5 48.6 30.1 43.3 59.3 23.4 31.2 58.1 180.8 27.3 41.1 24.7 13.3 25.2 37.0 50.2 60.3 42.7 19.8 43.0 187.4 52.2 35.1 17.8 32.8 38.2 41.3 145.2 76.9 64.5 60.7 72.9 33.8 50.5 84.4 83.8 15.3 81.3 107.2 39.5 42.4 25.2 72.7 59.9 32.6 27.3 87.0 102.2 30.7 52.2 82.8 OPA1 "FLJ12460, KIAA0567, MGM1, NPG, NTG" ENSG00000198836 "OPA1 mitochondrial dynamin like GTPase" O60313 3 193593144-193697811 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Apoptosis, Sensory transduction, Vision" Hydrolase "Cardiomyopathy, Deafness, Disease variant, Neurodegeneration, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 135.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036926, HPA036927" Supported Supported Nucleoplasm,Mitochondria NA NA 10000 "Cluster 14: Monocytes - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 6: Erythroid cells - Oxygen transport" "Nucleoplasm, Mitochondria" "HPA036926: AB_10671247, HPA036927: AB_2675388" "unprognostic (2.10e-2)" "unprognostic (9.23e-3)" "unprognostic (7.98e-2)" "prognostic unfavorable (8.61e-4)" "unprognostic (1.62e-2)" "unprognostic (4.59e-2)" "unprognostic (2.24e-1)" "unprognostic (1.86e-2)" "unprognostic (1.57e-1)" "unprognostic (1.08e-1)" "prognostic unfavorable (8.44e-5)" "unprognostic (3.48e-2)" "prognostic favorable (1.84e-4)" "unprognostic (2.92e-1)" "unprognostic (4.75e-1)" "unprognostic (4.50e-3)" "unprognostic (3.21e-1)" 15.0 12.0 14.3 7.6 17.4 25.6 12.8 15.2 19.5 10.4 9.4 18.9 16.8 10.9 9.1 14.6 8.1 10.2 39.3 18.6 17.4 18.3 20.9 8.5 11.8 16.4 15.4 8.4 10.1 23.1 3.8 11.7 16.8 12.3 16.6 9.6 11.7 13.3 24.2 11.9 13.8 13.5 12.4 9.3 14.6 6.3 15.2 12.7 13.9 44.5 12.4 13.0 5.1 13.7 58.9 18.8 18.2 20.2 15.8 25.0 19.3 27.5 26.2 30.0 29.0 45.2 19.3 38.6 58.1 27.0 27.3 37.3 32.7 31.7 53.5 46.5 25.7 67.9 16.7 23.1 24.9 55.8 29.8 28.4 27.6 30.0 40.9 18.5 26.2 15.7 28.4 37.0 30.2 46.5 21.9 30.9 25.8 33.9 59.9 27.8 40.1 41.6 22.7 36.1 39.8 24.2 41.8 46.3 29.5 14.1 60.3 43.5 26.3 27.7 20.8 29.3 58.7 33.1 41.3 74.0 30.5 43.7 28.4 9.7 7.3 7.1 5.8 8.2 5.5 6.8 5.5 5.6 7.8 5.1 5.6 6.0 2.7 4.7 17.3 4.0 6.6 5.2 14.3 17.4 15.2 19.5 18.6 17.4 16.4 15.4 16.8 12.4 15.2 13.7 24.8 16.0 24.0 72.1 27.5 15.9 16.4 17.4 24.5 19.5 20.9 13.5 135.2 22.8 20.1 18.4 31.3 19.0 24.6 31.4 17.6 19.3 7.7 20.3 25.2 23.8 23.4 86.3 106.8 24.0 14.9 24.6 31.1 26.1 19.6 25.6 14.3 39.1 17.9 21.9 106.7 20.6 10.2 25.6 14.7 13.5 15.8 28.1 21.4 58.1 22.9 14.6 11.3 87.4 98.1 28.9 12.1 14.7 29.3 18.7 24.6 34.1 19.6 23.4 6.6 21.3 26.2 15.1 16.6 34.3 22.4 17.9 22.3 28.2 26.7 22.1 OPA3 "FLJ22187, MGA3" ENSG00000125741 "Outer mitochondrial membrane lipid metabolism regulator OPA3" Q9H6K4 19 45527427-45602212 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Sensory transduction, Vision" "Cataract, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044881 Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 15: RT4 - Unknown function" "Cluster 52: Non-specific - Transcription" Cytosol Nucleoplasm "HPA044881: AB_10964052" "unprognostic (3.37e-1)" "unprognostic (3.89e-2)" "unprognostic (2.66e-1)" "unprognostic (5.71e-3)" "unprognostic (1.24e-2)" "unprognostic (2.87e-2)" "prognostic unfavorable (5.60e-4)" "unprognostic (3.14e-3)" "unprognostic (4.53e-2)" "unprognostic (8.06e-3)" "unprognostic (1.72e-3)" "unprognostic (8.73e-2)" "prognostic favorable (9.30e-12)" "unprognostic (5.85e-2)" "unprognostic (1.94e-1)" "unprognostic (3.82e-2)" "unprognostic (1.81e-1)" 4.8 7.2 3.3 4.7 3.4 4.0 3.5 4.4 5.2 3.0 3.7 4.6 4.0 4.9 3.0 5.8 3.4 3.3 10.5 3.2 3.1 7.4 7.8 4.4 4.7 4.9 4.0 3.4 4.4 12.0 6.0 4.4 5.0 3.8 3.9 6.4 4.0 4.1 11.1 5.8 5.0 4.7 2.5 5.8 4.9 8.9 5.5 4.6 4.6 12.9 4.7 4.1 3.5 3.2 15.2 18.9 7.4 7.3 4.8 5.9 11.3 9.7 8.9 10.1 10.7 8.8 10.5 13.0 6.9 9.8 11.5 12.0 12.5 13.3 8.9 24.0 12.6 20.1 10.8 9.1 8.8 14.1 25.0 8.9 10.1 11.2 12.2 5.8 7.3 7.6 17.5 14.2 6.9 9.3 11.3 5.8 6.5 12.6 12.9 10.9 6.7 7.1 8.0 26.9 5.5 6.6 12.4 11.3 5.2 6.6 6.3 8.0 15.9 8.5 9.7 7.1 16.7 9.5 19.1 10.6 8.2 10.1 13.1 5.6 5.3 2.9 3.6 7.8 3.6 4.4 3.2 3.1 5.6 3.9 3.9 4.0 4.7 7.8 10.5 5.1 4.8 3.6 3.3 3.4 4.4 5.2 3.2 3.1 4.9 4.0 5.0 2.5 5.5 3.2 11.0 12.8 11.7 8.5 23.0 18.7 22.4 14.6 13.1 22.8 9.2 7.9 25.4 17.2 11.6 11.0 52.1 25.6 15.7 18.8 25.4 18.4 18.5 12.8 13.8 15.2 13.8 5.7 9.5 21.1 29.8 10.6 14.3 20.1 15.9 8.9 11.4 21.9 16.3 20.2 10.2 14.5 16.2 11.4 28.3 20.2 6.2 17.4 14.2 4.7 19.0 15.1 11.3 3.0 8.1 18.2 19.2 6.4 11.9 15.8 21.2 16.8 10.7 36.0 0.0 23.3 23.6 23.9 13.1 11.2 19.6 36.3 14.4 19.5 16.6 16.7 OPN1LW "CBBM, CBP, COD5, RCP" ENSG00000102076 "Opsin 1, long wave sensitive" P04000 X 154144243-154159032 "Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Sensory transduction, Vision" "G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 2568 "retina: 256.7" "Cell type enriched" "Detected in some" 20 "Cone photoreceptor cells: 725.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 9: Photoreceptor cells - Phototransduction" "unprognostic (6.05e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 256.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.1 0.0 0.0 0.0 0.0 0.0 0.0 725.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 35.9 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 OPN1MW "CBBM, CBD, COD5, GCP, OPN1MW1" ENSG00000268221 "Opsin 1, medium wave sensitive" P04001 X 154182596-154196861 "Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins" "Sensory transduction, Vision" "G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 133 "retina: 13.3" "Cell type enriched" "Detected in single" 111 "Cone photoreceptor cells: 33.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 9: Photoreceptor cells - Phototransduction" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 33.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 OPN1SW "BCP, BOP, CBT" ENSG00000128617 "Opsin 1, short wave sensitive" P03999 7 128772485-128775794 "Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins" "Sensory transduction, Vision" "G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 84 "retina: 41.0" "Cell type enriched" "Detected in some" 12 "Cone photoreceptor cells: 41.7" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 5 "LHCN-M2: 1.5" "Not detected" "Not detected" "Not detected" "Not detected" "HPA013562, HPA014083" Enhanced Approved "Nucleoplasm,Nuclear bodies,Cytokinetic bridge,Cytosol" Yes NA "Cluster 79: Retina - Phototransduction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 9: Photoreceptor cells - Phototransduction" Nucleoplasm "Nuclear bodies, Cytokinetic bridge, Cytosol" "HPA013562: AB_2668850, HPA014083: AB_2668938" "unprognostic (2.88e-1)" "unprognostic (5.17e-2)" "unprognostic (2.22e-2)" "unprognostic (1.33e-2)" "unprognostic (2.55e-2)" "unprognostic (2.16e-1)" "prognostic unfavorable (8.50e-5)" "unprognostic (1.13e-1)" "unprognostic (1.27e-1)" "unprognostic (6.33e-2)" "unprognostic (3.79e-1)" "unprognostic (6.05e-2)" "prognostic unfavorable (2.26e-8)" "prognostic unfavorable (5.98e-8)" "unprognostic (2.53e-1)" "unprognostic (8.99e-2)" "prognostic unfavorable (9.33e-4)" 0.2 0.1 0.1 0.0 0.0 0.0 0.1 0.2 0.1 0.1 0.2 0.4 0.0 0.4 0.0 0.0 0.1 0.0 0.4 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.1 0.0 41.0 0.2 0.0 0.2 0.0 0.2 0.0 0.0 0.1 0.2 0.2 0.0 0.0 0.1 0.0 0.0 0.2 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.5 0.0 0.1 0.0 0.3 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.4 0.0 0.0 0.0 41.7 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.2 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 3.3 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.1 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 OPTN "FIP-2, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP" ENSG00000123240 Optineurin Q96CV9 10 13099449-13138308 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters" "Autophagy, Host-virus interaction, Immunity, Innate immunity" "Amyotrophic lateral sclerosis, Disease variant, Glaucoma, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 6 "skeletal muscle: 879.4;tongue: 394.5" "Cell type enhanced" "Detected in all" "Late spermatids: 933.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003279, HPA003360, CAB019303" Approved Enhanced Cytosol NA NA 370000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 31: Spermatids - Spermatogenesis" Cytosol "CAB019303: , HPA003279: AB_1079527, HPA003360: AB_1079528" "unprognostic (2.84e-2)" "unprognostic (3.37e-1)" "unprognostic (3.79e-3)" "unprognostic (6.46e-3)" "unprognostic (5.58e-2)" "unprognostic (3.74e-2)" "unprognostic (5.15e-3)" "unprognostic (3.14e-2)" "unprognostic (2.68e-2)" "unprognostic (2.16e-1)" "unprognostic (1.40e-2)" "unprognostic (6.14e-1)" "prognostic unfavorable (5.81e-5)" "unprognostic (7.62e-2)" "unprognostic (5.67e-2)" "unprognostic (7.93e-2)" "unprognostic (2.09e-2)" 92.7 90.4 45.7 35.8 53.5 50.1 64.0 45.9 55.9 52.3 36.8 55.4 63.2 39.7 21.9 61.8 37.7 41.6 105.7 54.9 49.2 72.3 73.8 58.9 45.7 48.0 53.9 92.1 35.4 33.1 33.8 57.5 52.9 34.1 57.2 48.8 46.3 41.4 879.4 77.9 69.6 43.4 44.3 57.3 56.1 72.8 45.4 30.1 27.1 394.5 37.6 43.8 56.3 49.0 83.3 23.1 12.8 17.8 171.4 175.6 15.2 97.6 110.7 72.1 119.0 41.1 108.1 0.7 37.6 134.3 113.2 75.6 17.3 93.5 54.8 192.9 9.2 17.2 32.1 22.0 175.4 0.6 59.5 94.6 72.6 69.2 71.8 177.9 62.4 23.8 21.5 123.7 98.7 17.6 8.3 2.3 5.2 22.4 10.3 1.4 25.5 8.5 87.9 57.6 2.8 13.6 84.9 25.0 64.3 49.9 54.6 11.4 171.6 58.8 28.9 81.0 27.5 63.3 23.5 0.6 88.3 14.3 11.4 47.9 2.5 0.3 56.1 1.5 43.3 18.0 71.2 65.8 0.5 11.7 28.0 34.5 1.7 51.2 3.8 5.2 109.6 30.2 45.7 53.5 45.9 55.9 54.9 49.2 48.0 53.9 52.9 44.3 45.4 49.0 68.2 67.3 29.4 18.6 25.9 74.4 46.6 104.5 67.2 38.7 30.5 32.9 237.7 68.6 81.3 31.3 18.8 112.8 89.8 199.8 33.2 135.5 281.9 36.0 38.6 82.4 42.6 126.5 48.9 114.0 39.8 91.6 88.7 37.4 70.8 92.8 47.8 30.9 31.6 90.9 26.6 106.4 65.1 15.1 26.0 933.6 95.7 14.5 90.7 25.3 36.6 36.4 119.4 13.6 28.1 166.3 186.9 103.4 86.3 92.3 209.9 162.4 73.7 103.4 111.7 63.1 106.6 102.0 13.7 58.1 77.9 75.4 107.5 166.3 44.1 75.0 OSBPL2 "DFNA67, KIAA0772, ORP-2" ENSG00000130703 "Oxysterol binding protein like 2" Q9H1P3 20 62231922-62296213 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Lipid transport, Transport" "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 94.6" "Lineage enriched" "Detected in all" 5 "granulocytes: 94.6" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041127, HPA042659" Uncertain Approved Cytosol NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 27: Brain & Skin - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 22: Epithelial cell types - Mixed function" Cytosol "HPA041127: AB_10962008, HPA042659: AB_10960683" "unprognostic (1.00e-3)" "unprognostic (7.20e-3)" "unprognostic (1.31e-1)" "unprognostic (6.00e-2)" "unprognostic (1.82e-1)" "unprognostic (1.73e-3)" "unprognostic (3.79e-2)" "unprognostic (9.60e-2)" "unprognostic (6.22e-2)" "unprognostic (1.50e-1)" "unprognostic (1.73e-1)" "unprognostic (6.82e-3)" "prognostic favorable (4.20e-5)" "unprognostic (3.86e-2)" "unprognostic (8.13e-2)" "unprognostic (4.00e-1)" "unprognostic (3.32e-2)" 14.6 15.2 21.1 13.4 21.2 32.9 18.9 38.9 21.4 21.9 20.0 24.3 22.8 14.0 15.8 40.7 15.6 20.0 25.4 16.6 20.3 20.8 18.0 16.2 14.3 23.7 24.0 15.8 39.7 26.4 26.4 13.7 22.3 19.8 22.7 14.5 24.9 18.8 18.0 43.5 21.6 17.4 19.4 24.9 27.9 14.9 29.8 17.2 21.9 11.9 20.4 23.1 29.8 19.4 23.9 17.0 19.6 18.3 19.4 19.1 18.5 14.2 27.9 46.6 32.1 61.0 24.1 11.5 37.1 28.4 41.8 40.7 18.9 42.4 25.7 13.7 17.7 30.6 21.5 31.2 19.0 11.8 26.6 17.7 61.0 20.8 23.3 22.1 19.1 29.4 20.3 21.2 13.5 19.4 17.2 19.8 6.4 43.5 15.0 15.9 23.5 15.3 23.6 48.2 25.6 16.7 25.7 48.2 24.3 25.9 32.1 21.0 13.2 23.2 17.0 24.7 17.3 24.5 37.4 17.5 25.7 8.4 14.9 16.1 9.2 34.5 13.0 11.7 11.4 13.7 10.5 13.7 9.9 10.9 9.5 11.4 94.6 16.8 9.9 7.1 17.5 10.9 21.1 21.2 38.9 21.4 16.6 20.3 23.7 24.0 22.3 19.4 29.8 19.4 27.1 16.0 18.3 17.3 16.5 20.1 24.8 24.4 14.2 18.9 24.7 16.6 61.2 15.7 28.2 11.0 6.2 13.4 21.6 44.5 31.3 22.7 33.0 22.6 12.0 18.1 16.3 24.2 13.9 20.1 14.8 17.8 42.8 34.2 10.8 19.2 12.8 14.1 12.3 18.5 21.7 29.6 22.4 11.1 8.0 17.4 17.4 14.3 8.8 10.3 16.8 18.2 27.8 9.0 15.5 39.8 37.0 13.2 21.9 38.8 30.2 14.1 34.3 15.9 13.1 14.8 13.1 22.8 11.1 25.2 27.8 37.1 18.5 12.0 25.7 58.7 OTOA "CT108, DFNB22" ENSG00000155719 Otoancorin Q7RTW8 16 21663968-21761935 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" Hearing "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 7 "lymphoid tissue: 1.8;testis: 4.0" "Cell type enhanced" "Detected in some" "Hofbauer cells: 111.8;Kupffer cells: 60.5;Late spermatids: 18.7;Macrophages: 34.4" "Not detected" "Not detected" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "plasmacytoid DC: 1.3" "Lineage enriched" "Detected in single" 13 "dendritic cells: 1.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA041405 Enhanced "Secreted in other tissues" NA NA 51000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 78: Testis - Spermatogenesis" "Cluster 4: Macrophages - Innate immune response" "HPA041405: AB_10796344" "unprognostic (7.96e-2)" "unprognostic (2.44e-4)" "unprognostic (1.66e-2)" "unprognostic (9.69e-2)" "unprognostic (2.15e-1)" "unprognostic (1.35e-1)" "unprognostic (5.11e-1)" "unprognostic (4.71e-2)" "unprognostic (7.92e-2)" "unprognostic (3.58e-1)" "unprognostic (1.08e-2)" "unprognostic (2.15e-1)" "unprognostic (1.08e-4)" "unprognostic (1.83e-1)" "unprognostic (1.20e-1)" "unprognostic (2.24e-1)" "unprognostic (2.18e-2)" 0.1 0.2 0.2 0.0 0.2 0.2 0.1 0.1 0.3 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.2 0.1 0.0 0.2 0.2 0.2 0.2 0.1 0.0 0.0 0.0 0.4 0.0 0.2 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 1.8 0.0 4.0 0.2 0.2 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.2 0.2 0.1 0.3 0.2 0.1 0.2 0.1 0.2 0.1 0.2 0.3 8.4 0.0 0.5 0.3 0.7 0.0 0.1 0.0 0.0 0.0 0.2 0.4 0.9 0.0 0.0 1.8 0.0 0.4 0.1 0.3 0.0 0.2 11.6 0.3 0.2 1.0 1.2 0.0 2.6 0.4 0.8 0.3 0.0 0.5 5.7 0.1 0.7 0.4 111.8 0.0 1.8 0.1 0.0 60.5 3.7 18.7 0.3 34.4 1.8 0.0 1.9 0.0 0.0 0.5 0.2 0.1 1.4 0.0 0.1 0.2 0.0 0.7 0.0 0.0 6.6 0.2 0.7 9.4 7.4 0.0 0.1 0.5 0.2 0.1 0.2 0.2 OTOF "DFNB6, DFNB9, FER1L2" ENSG00000115155 Otoferlin Q9HC10 2 26457203-26558756 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" Hearing "Deafness, Disease variant, Neuropathy, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 13 "bone marrow: 6.4;brain: 23.1" "Group enriched" "Detected in some" 4 "Inhibitory neurons: 4.0;Skeletal myocytes: 6.8" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 19 "HDLM-2: 32.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA012410 Approved NA NA "Cluster 65: Brain - Ion transport" "Cluster 44: HDLM-2 - Immune response" "Cluster 50: Fibroblasts - ECM organization" "HPA012410: AB_1854836" "unprognostic (4.01e-3)" "unprognostic (7.85e-2)" "unprognostic (8.95e-2)" "unprognostic (7.20e-5)" "unprognostic (1.82e-2)" "unprognostic (1.60e-2)" "unprognostic (1.36e-1)" "unprognostic (2.46e-1)" "unprognostic (6.61e-2)" "unprognostic (1.78e-2)" "unprognostic (1.26e-1)" "unprognostic (2.97e-3)" "unprognostic (4.85e-14)" "unprognostic (1.33e-2)" "unprognostic (5.19e-1)" "unprognostic (9.65e-2)" "unprognostic (8.96e-5)" 0.2 0.5 23.1 0.3 16.3 6.4 0.2 0.2 13.1 0.1 0.0 0.2 0.4 0.0 0.0 0.1 0.0 0.3 0.1 4.1 3.3 0.0 0.0 0.2 0.1 5.2 2.8 0.0 0.1 0.0 0.0 0.0 4.0 0.1 0.0 0.0 0.0 0.0 0.7 0.3 0.3 0.1 4.2 0.5 0.2 1.1 3.0 0.9 0.1 0.3 0.1 0.1 0.1 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 32.8 0.0 0.3 0.0 0.1 0.0 0.0 1.7 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 23.1 16.3 0.2 13.1 4.1 3.3 5.2 2.8 4.0 4.2 3.0 0.4 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.5 1.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.8 0.2 0.0 0.1 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.8 0.2 0.8 0.3 0.0 0.0 0.1 0.5 0.4 0.0 0.0 OTOG "FLJ46346, mlemp, OTGN" ENSG00000188162 Otogelin Q6ZRI0 11 17547259-17647150 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in single" "pituitary gland: 1.4" "Group enriched" "Detected in some" 5 "Early spermatids: 11.9;Late spermatids: 28.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 13 "CACO-2: 8.2" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted in other tissues" NA NA "Cluster 77: Retina - Visual perception" "Cluster 39: CACO-2 - Unknown function" "Cluster 31: Spermatids - Spermatogenesis" "unprognostic (1.25e-2)" "unprognostic (1.19e-1)" "unprognostic (6.95e-3)" "unprognostic (1.85e-6)" "unprognostic (1.89e-1)" "unprognostic (3.60e-1)" "unprognostic (5.14e-5)" "unprognostic (1.78e-1)" "unprognostic (8.97e-2)" "unprognostic (1.57e-2)" "unprognostic (4.72e-5)" "unprognostic (5.55e-2)" "unprognostic (1.48e-1)" 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 1.4 0.0 0.1 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.2 0.1 0.1 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.5 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.9 0.1 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 28.2 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.7 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 OTOGL "C12orf64, FLJ90579" ENSG00000165899 "Otogelin like" Q3ZCN5 12 80099537-80380880 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "heart muscle: 1.9;kidney: 5.1" "Group enriched" "Detected in some" 5 "Excitatory neurons: 51.2;Oligodendrocyte precursor cells: 42.3" "Cancer enhanced" "Detected in single" "testis cancer: 0.5" "Region enhanced" "Detected in single" "cerebral cortex: 1.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "SCLC-21H: 1.3;U-87 MG: 2.4" "Not detected" "Not detected" "Region enriched" "Detected in single" 6 "basal ganglia: 4.2" "HPA040364, HPA053392" Uncertain Approved Cytosol "Secreted in other tissues" NA NA "Cluster 7: Kidney - Transmembrane transport" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "HPA040364: AB_10795365, HPA053392: AB_2682135" "unprognostic (2.43e-1)" "unprognostic (2.78e-2)" "unprognostic (2.55e-2)" "unprognostic (1.50e-1)" "unprognostic (5.99e-2)" "unprognostic (3.10e-1)" "unprognostic (3.34e-3)" "unprognostic (4.76e-2)" "unprognostic (2.72e-2)" "unprognostic (4.52e-2)" "unprognostic (2.79e-2)" "unprognostic (1.57e-1)" "unprognostic (1.95e-5)" "unprognostic (1.41e-1)" "unprognostic (1.11e-1)" "unprognostic (2.79e-2)" "unprognostic (2.04e-2)" 0.1 0.0 0.5 0.0 0.7 0.0 0.1 0.0 1.0 0.1 0.0 0.4 0.0 0.1 0.1 0.1 0.1 0.1 1.9 0.3 0.0 5.1 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.3 0.5 0.1 0.1 0.1 0.5 0.0 0.1 0.4 0.0 0.1 0.2 0.0 0.1 0.0 0.3 0.0 0.1 0.0 0.1 0.1 0.2 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 1.3 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.1 0.1 0.9 0.0 0.0 0.3 0.0 0.0 2.4 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.7 0.0 1.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 8.8 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.3 7.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 1.4 0.1 0.1 0.2 0.0 0.0 51.2 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.2 0.0 0.0 0.0 0.8 0.0 0.0 0.0 1.9 0.0 0.0 0.0 42.3 1.6 0.0 0.0 0.0 0.0 0.0 0.0 5.6 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 OVOL2 "bA504H3.3, CHED, CHED1, HOVO2, ZNF339" ENSG00000125850 "Ovo like zinc finger 2" Q9BRP0 20 17956979-18059188 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Developmental protein, DNA-binding" "Corneal dystrophy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "salivary gland: 7.1;stomach 1: 7.9" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 24.4;Spermatocytes: 37.9" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 5.6;CACO-2: 4.1;CAPAN-2: 7.3;HaCaT: 5.4;OE19: 10.0;SCLC-21H: 8.3;SK-BR-3: 5.4" "Region enhanced" "Detected in many" "cerebral cortex: 10.3" "Group enriched" "Detected in some" 5 "cerebral cortex: 3.9;hippocampal formation: 3.3" HPA038531 Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 24: Salivary gland - Salivary secretion" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm Cytosol "HPA038531: AB_10673012" "unprognostic (2.85e-2)" "unprognostic (5.13e-2)" "unprognostic (2.41e-2)" "unprognostic (7.35e-2)" "unprognostic (2.14e-1)" "unprognostic (5.14e-2)" "unprognostic (1.90e-1)" "unprognostic (5.23e-2)" "unprognostic (1.40e-1)" "unprognostic (2.61e-1)" "unprognostic (2.63e-2)" "unprognostic (1.62e-1)" "unprognostic (1.84e-4)" "unprognostic (4.77e-3)" "unprognostic (2.92e-1)" "unprognostic (2.57e-2)" "unprognostic (3.76e-2)" 0.0 0.0 0.0 0.1 0.1 0.0 2.8 0.0 0.1 1.5 0.0 3.5 2.9 0.3 0.5 5.3 1.0 0.3 0.0 0.0 0.0 1.1 0.0 1.5 0.0 0.0 0.0 0.0 4.5 0.4 1.2 0.1 0.0 4.1 1.3 0.0 7.1 0.7 0.0 6.7 2.3 0.0 0.0 0.0 7.9 1.4 0.0 0.1 3.3 0.0 0.2 1.2 3.7 0.0 5.6 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 4.1 7.3 0.0 1.0 0.0 0.3 5.4 1.0 1.3 0.0 0.0 1.5 0.0 0.3 0.0 0.0 0.0 0.3 0.0 2.8 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.7 0.0 0.0 0.0 10.0 0.1 0.0 0.0 2.1 0.1 2.6 8.3 0.0 0.0 5.4 0.0 0.1 2.8 0.9 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 6.4 8.4 0.3 0.1 8.3 11.4 4.8 4.0 0.0 14.6 11.7 1.4 8.6 8.8 1.8 0.0 1.7 0.2 17.1 0.0 8.4 18.6 24.4 1.3 0.3 3.6 0.0 3.3 10.9 3.2 0.2 17.9 18.4 0.0 0.0 0.0 0.0 0.1 1.7 1.7 15.5 10.2 0.0 0.7 7.4 0.3 0.5 0.0 0.0 0.0 0.7 0.0 1.0 0.3 16.9 10.5 0.4 0.0 12.9 12.0 1.6 6.4 0.0 0.0 0.0 0.7 37.9 0.7 4.9 9.8 0.1 0.4 0.0 12.3 15.1 P2RX2 "DFNA41, P2X2" ENSG00000187848 "Purinergic receptor P2X 2" Q9UBL9 12 132618776-132622388 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Hearing, Ion transport, Transport" "Ion channel, Ligand-gated ion channel, Receptor" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 11.3;epididymis: 21.8;prostate: 14.1" "Cell type enhanced" "Detected in some" "Breast glandular cells: 1.6;Endometrial ciliated cells: 2.6;Fibroblasts: 8.3;Gastric mucus-secreting cells: 1.1;Peritubular cells: 3.0" "Cancer enhanced" "Detected in some" "testis cancer: 1.3" "Group enriched" "Detected in many" 7 "amygdala: 9.2;cerebral cortex: 11.3;hippocampal formation: 10.1" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "MCF7: 5.1;T-47d: 11.2" "Not detected" "Not detected" "Low region specificity" "Detected in some" NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 50: Fibroblasts - ECM organization" "unprognostic (1.12e-1)" "unprognostic (1.49e-2)" "unprognostic (5.92e-2)" "unprognostic (5.94e-2)" "unprognostic (2.79e-1)" "unprognostic (1.07e-1)" "unprognostic (3.12e-1)" "unprognostic (5.79e-3)" "unprognostic (6.75e-2)" "unprognostic (2.92e-1)" "unprognostic (1.11e-2)" "unprognostic (3.66e-2)" "unprognostic (1.88e-2)" "unprognostic (6.21e-2)" "unprognostic (3.05e-1)" "unprognostic (9.12e-2)" 1.1 0.1 9.2 0.6 0.4 0.1 0.2 0.3 11.3 0.7 0.0 2.4 1.1 0.2 21.8 7.2 9.3 0.1 0.0 10.1 1.5 2.5 0.4 4.9 1.9 0.1 0.2 0.3 0.5 0.7 1.3 0.4 0.1 14.1 0.3 0.0 0.1 9.0 0.0 0.2 4.3 0.1 0.0 3.2 1.7 1.5 1.0 0.4 0.2 0.0 0.8 1.0 1.9 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.8 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.1 0.0 5.1 0.1 0.3 0.5 0.0 0.0 0.1 0.1 0.0 0.0 0.3 0.1 0.0 0.0 1.9 0.0 0.6 11.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.0 0.6 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 9.2 0.4 0.3 11.3 10.1 1.5 0.1 0.2 0.1 0.0 1.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.6 0.1 0.1 0.0 0.0 0.1 0.0 0.1 8.3 1.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 3.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.7 0.1 0.0 0.0 0.0 0.0 0.0 0.1 P3H2 "FLJ10718, LEPREL1, MLAT4" ENSG00000090530 "Prolyl 3-hydroxylase 2" Q8IVL5 3 189956728-190122437 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Dioxygenase, Oxidoreductase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 80.3;Granulosa cells: 124.1;Microglial cells: 91.8;Theca cells: 74.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 22 "plasmacytoid DC: 28.9" "Lineage enriched" "Detected in single" 90 "dendritic cells: 28.9" "Cell line enhanced" "Detected in many" "GAMG: 120.2;HaCaT: 109.9;RPTEC TERT1: 109.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA007890, HPA013355, HPA013611" Approved Supported "Nucleoplasm,Golgi apparatus,Vesicles,Cytosol" "Intracellular and membrane" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 64: Macrophages - Immune response" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 40: Granulosa cells - Unknown function" "Golgi apparatus" "Nucleoplasm, Vesicles, Cytosol" "HPA007890: AB_1852796, HPA013355: AB_1852798, HPA013611: " "unprognostic (4.90e-2)" "unprognostic (1.57e-1)" "unprognostic (3.76e-1)" "unprognostic (4.32e-3)" "unprognostic (1.97e-2)" "unprognostic (7.75e-2)" "unprognostic (9.68e-2)" "unprognostic (2.17e-1)" "unprognostic (3.15e-1)" "unprognostic (1.19e-1)" "unprognostic (1.03e-3)" "unprognostic (1.60e-1)" "unprognostic (1.15e-2)" "unprognostic (1.80e-2)" "unprognostic (1.48e-1)" "unprognostic (1.10e-1)" "unprognostic (4.01e-2)" 4.9 41.6 2.8 4.9 3.1 1.0 6.5 3.0 3.1 17.0 1.8 24.0 2.7 17.6 18.5 11.0 8.0 4.8 8.8 3.3 4.8 51.3 7.0 28.7 2.4 7.6 4.7 16.1 3.6 2.3 8.2 9.2 6.7 37.6 10.4 19.3 4.9 26.5 1.2 17.8 6.7 32.4 5.2 54.8 23.9 4.2 4.9 5.2 3.0 1.7 2.0 11.9 19.9 8.3 46.9 18.2 35.1 0.2 0.6 1.4 42.1 48.7 19.3 7.8 12.6 15.0 18.0 0.1 27.1 8.6 120.2 109.9 0.1 65.3 16.3 0.4 6.2 0.1 12.1 0.3 35.4 0.2 0.3 16.9 21.4 15.2 5.4 73.5 1.4 0.1 0.1 0.4 12.3 1.1 0.1 0.4 11.0 31.3 3.7 0.1 7.1 2.8 109.8 77.5 2.5 0.3 66.1 3.7 29.3 51.1 0.1 0.7 24.4 45.9 16.8 0.4 8.9 3.4 0.2 0.5 10.6 0.2 60.2 0.3 0.2 0.1 0.0 0.1 0.0 0.1 0.0 0.0 1.2 0.0 0.0 0.0 0.2 0.1 0.0 28.9 0.0 0.2 2.8 3.1 3.0 3.1 3.3 4.8 7.6 4.7 6.7 5.2 4.9 8.3 5.7 48.1 80.3 19.2 1.0 0.0 7.7 0.0 13.6 2.3 1.6 9.9 1.0 2.8 3.1 44.1 4.2 42.0 9.5 19.8 5.9 4.7 19.6 2.0 27.3 10.5 0.0 2.7 55.6 0.8 14.7 10.3 8.6 1.5 1.3 124.1 32.5 0.8 11.4 10.1 60.4 0.5 0.0 3.2 0.0 14.9 4.7 5.6 0.0 91.8 0.8 44.5 0.0 43.7 4.4 30.6 1.9 0.0 0.2 15.1 0.0 26.2 0.0 1.2 0.0 10.9 45.2 0.5 0.9 13.5 0.0 38.6 0.7 74.3 2.1 3.9 P4HA2 C-P4Halpha(II) ENSG00000072682 "Prolyl 4-hydroxylase subunit alpha 2" O15460 5 132190147-132295315 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Dioxygenase, Oxidoreductase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 115.6;Endometrial stromal cells: 96.9;Skeletal myocytes: 109.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "HHSteC: 324.2;U-87 MG: 323.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA016997, HPA027824, CAB062557" Enhanced Enhanced "Endoplasmic reticulum,Vesicles" "Intracellular and membrane" No No 13000 "Cluster 1: Neutrophils - Mixed function" "Cluster 7: Kidney - Transmembrane transport" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Endoplasmic reticulum, Vesicles" "CAB062557: AB_2665641, HPA016997: AB_2669501, HPA027824: AB_2672402" "unprognostic (1.30e-3)" "prognostic unfavorable (1.24e-5)" "unprognostic (2.56e-3)" "unprognostic (1.28e-3)" "unprognostic (2.08e-3)" "unprognostic (1.62e-3)" "unprognostic (1.16e-3)" "unprognostic (1.93e-3)" "unprognostic (2.83e-2)" "unprognostic (1.92e-1)" "unprognostic (8.98e-2)" "unprognostic (1.91e-1)" "prognostic unfavorable (2.77e-7)" "unprognostic (2.50e-2)" "unprognostic (1.61e-1)" "unprognostic (2.23e-1)" "prognostic unfavorable (3.12e-4)" 17.4 11.7 11.9 16.1 12.1 2.4 12.3 11.4 28.4 29.5 42.2 28.7 22.6 31.1 76.7 19.6 29.6 19.9 40.6 14.4 17.2 80.0 10.5 31.5 2.5 11.4 14.3 8.6 70.7 10.9 19.9 35.1 19.1 10.8 32.7 7.8 32.5 17.1 13.0 16.7 26.8 52.6 10.0 8.7 20.5 9.7 16.8 11.3 20.7 22.9 8.3 22.9 22.3 12.2 57.0 34.9 11.2 57.2 149.2 173.7 61.1 261.9 223.7 108.9 265.0 78.9 50.3 1.5 71.8 283.3 120.5 70.2 33.2 136.5 172.7 41.5 11.9 0.6 48.1 49.0 324.2 0.0 33.9 104.6 193.1 128.8 117.4 162.7 59.1 0.1 21.2 3.6 134.0 23.2 0.2 0.5 3.0 53.7 27.2 0.9 3.6 9.8 31.1 11.0 5.4 15.8 67.7 22.3 47.9 84.1 28.4 3.7 88.9 171.7 63.5 51.0 57.1 24.4 28.1 11.8 323.4 0.4 48.3 0.0 0.4 0.0 0.8 0.3 0.7 0.0 0.4 0.1 0.2 0.0 0.0 0.1 1.0 0.9 0.0 0.3 0.0 0.2 11.9 12.1 11.4 28.4 14.4 17.2 11.4 14.3 19.1 10.0 16.8 12.2 13.0 35.3 10.3 7.5 1.1 16.8 43.6 115.6 23.9 11.6 9.5 9.5 13.3 8.6 36.9 11.0 22.9 2.6 0.3 43.2 5.9 68.3 1.4 26.7 96.9 12.2 15.0 0.0 7.7 71.8 70.2 61.6 12.8 28.0 5.7 11.1 9.3 7.8 7.6 0.0 7.7 18.6 32.6 1.3 5.5 2.0 8.1 4.4 30.2 2.8 2.6 6.8 0.0 1.5 1.2 81.9 41.0 5.3 3.0 19.6 41.4 44.6 71.9 5.2 26.3 109.4 47.6 23.0 29.1 6.8 9.8 7.5 4.8 10.4 13.8 15.3 PACS2 "KIAA0602, PACS1L" ENSG00000179364 "Phosphofurin acidic cluster sorting protein 2" Q86VP3 14 105300563-105398147 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters" "Apoptosis, Host-virus interaction" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 136.6;skeletal muscle: 98.5" "Cell type enhanced" "Detected in all" "Horizontal cells: 97.6;Oligodendrocytes: 169.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA077892 Approved Mitochondria NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 70: Brain - Nervous system development" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Mitochondria "HPA077892: AB_2686865" "unprognostic (4.31e-2)" "unprognostic (2.61e-1)" "unprognostic (4.53e-2)" "unprognostic (1.24e-1)" "unprognostic (3.09e-2)" "unprognostic (4.08e-2)" "prognostic unfavorable (3.11e-5)" "unprognostic (1.18e-2)" "unprognostic (1.37e-1)" "unprognostic (1.90e-1)" "prognostic favorable (2.95e-4)" "unprognostic (1.49e-1)" "prognostic favorable (1.56e-4)" "unprognostic (2.08e-1)" "unprognostic (3.80e-1)" "unprognostic (2.58e-1)" "unprognostic (1.30e-1)" 22.4 16.1 48.4 10.6 101.5 9.0 18.7 104.4 61.3 18.1 4.7 24.6 10.9 21.0 5.4 11.2 19.0 11.2 23.8 43.2 58.0 12.4 6.9 16.1 8.5 136.6 110.6 20.0 28.8 11.7 21.6 8.8 119.6 15.0 6.6 12.2 16.3 11.5 98.5 12.6 14.2 10.0 80.8 16.0 17.4 19.8 106.1 9.4 14.1 46.1 5.5 19.3 14.1 126.8 17.5 23.8 21.9 20.7 21.5 20.6 25.9 13.0 15.0 11.0 9.6 10.4 32.5 19.0 21.5 20.0 14.1 19.7 13.5 18.7 7.9 23.7 11.0 8.7 10.0 15.6 28.1 7.1 15.0 24.1 17.5 7.7 17.7 13.9 20.1 18.9 5.4 17.2 9.7 54.9 12.1 9.5 8.5 22.1 19.4 26.5 13.3 12.1 9.3 39.7 49.0 25.8 12.4 11.1 19.4 13.7 28.1 13.2 30.8 16.2 7.2 25.6 13.1 22.3 15.6 7.2 24.6 12.8 16.1 0.0 0.6 0.1 0.3 1.1 0.6 0.0 0.3 0.4 1.1 0.2 0.1 0.4 0.1 1.0 1.9 2.3 0.8 0.4 48.4 101.5 104.4 61.3 43.2 58.0 136.6 110.6 119.6 80.8 106.1 126.8 28.3 9.6 14.7 41.1 3.3 9.1 7.5 7.1 8.0 30.5 15.1 14.4 21.4 8.6 12.6 5.5 12.5 4.3 15.1 21.5 13.7 13.9 77.1 13.8 15.7 21.1 13.1 4.2 29.7 23.0 3.2 15.5 20.4 18.3 1.3 28.8 19.2 10.8 17.6 97.6 41.0 14.6 8.2 15.7 23.0 78.7 17.4 17.1 26.6 30.9 8.4 17.0 7.2 23.1 169.3 14.2 12.6 16.6 7.1 9.0 19.3 12.3 7.7 23.4 6.6 20.6 14.2 18.3 14.6 8.1 8.4 3.4 8.0 30.6 19.5 8.0 PANK2 "C20orf48, FLJ11729, HARP, HSS, NBIA1, PKAN" ENSG00000125779 "Pantothenate kinase 2" Q9BZ23 20 3888839-3929887 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Angiogenesis, Coenzyme A biosynthesis" "Kinase, Transferase" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008440 Approved Supported Cytosol NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 66: Spermatocytes - Spermatogenesis" Cytosol "HPA008440: AB_1079559" "unprognostic (4.50e-2)" "unprognostic (7.96e-3)" "unprognostic (2.26e-1)" "unprognostic (1.39e-2)" "unprognostic (1.68e-1)" "unprognostic (6.00e-2)" "prognostic unfavorable (1.20e-5)" "unprognostic (2.75e-1)" "unprognostic (3.39e-1)" "unprognostic (2.52e-1)" "unprognostic (3.02e-2)" "unprognostic (1.65e-1)" "unprognostic (6.01e-3)" "unprognostic (1.73e-2)" "unprognostic (2.18e-3)" "unprognostic (2.63e-1)" "unprognostic (1.81e-1)" 13.0 12.3 14.5 16.8 13.7 20.9 12.2 15.3 15.9 11.9 14.1 11.4 8.4 11.0 11.3 20.0 16.3 12.1 8.7 15.5 13.5 15.7 18.3 14.1 18.5 12.7 14.1 12.9 10.3 10.9 8.9 15.3 13.3 12.0 14.2 10.3 11.9 10.7 9.6 11.7 11.6 13.7 12.7 14.9 9.1 25.9 13.9 16.8 15.4 11.2 22.0 15.6 9.9 12.4 39.3 29.4 33.7 18.6 39.3 32.6 15.0 25.6 34.2 38.3 48.3 40.8 25.4 34.6 10.6 34.9 70.2 34.9 34.7 57.3 49.3 8.8 9.8 47.4 22.7 80.2 33.3 33.6 15.9 28.7 26.4 39.7 28.7 17.0 36.0 23.3 34.7 30.5 42.5 11.7 30.0 30.3 28.8 22.9 19.5 20.3 46.0 22.4 26.2 45.7 36.2 16.7 30.0 44.3 78.1 32.6 23.6 28.1 24.6 47.7 17.8 60.7 43.3 14.0 50.8 23.3 15.0 30.7 34.2 3.0 10.5 3.4 3.6 11.1 3.5 3.8 3.7 3.4 8.5 4.5 4.1 3.4 5.9 6.8 9.4 3.0 5.9 4.0 14.5 13.7 15.3 15.9 15.5 13.5 12.7 14.1 13.3 12.7 13.9 12.4 23.8 19.2 11.7 23.8 29.2 25.5 17.5 12.0 41.5 22.0 15.8 17.3 9.8 7.2 13.4 14.7 25.0 29.4 38.6 14.4 23.5 19.4 83.1 24.1 20.6 26.7 20.3 42.7 28.6 17.8 36.0 21.1 24.5 24.1 7.6 20.1 26.0 14.0 33.8 35.3 25.3 12.7 10.2 52.8 37.9 17.3 21.1 34.3 19.6 29.0 55.0 14.1 35.0 23.1 17.7 15.9 12.8 22.6 33.2 20.9 15.1 20.6 20.2 21.1 6.6 14.1 23.1 54.6 25.9 37.7 24.3 18.6 31.6 21.2 15.0 20.0 PARK7 "DJ-1, DJ1, GATD2" ENSG00000116288 "Parkinsonism associated deglycase" Q99497 1 7954291-7985505 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, DNA damage, DNA repair, Fertilization, Inflammatory response, Stress response" "Chaperone, Hydrolase, Protease, RNA-binding" "Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004190, CAB005870" Supported Supported Nucleoplasm,Cytosol NA NA 35000000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Cytosol" "CAB005870: AB_444361, HPA004190: AB_1079566" "unprognostic (6.88e-3)" "unprognostic (7.50e-2)" "unprognostic (3.48e-2)" "unprognostic (1.16e-2)" "unprognostic (4.08e-2)" "unprognostic (5.68e-2)" "unprognostic (7.45e-2)" "unprognostic (9.63e-2)" "unprognostic (2.01e-1)" "unprognostic (1.66e-2)" "unprognostic (1.12e-1)" "unprognostic (2.02e-1)" "unprognostic (1.96e-3)" "unprognostic (8.17e-2)" "unprognostic (1.32e-1)" "unprognostic (1.30e-1)" "unprognostic (7.43e-2)" 249.4 373.6 283.5 213.7 290.0 205.0 235.7 292.9 403.4 201.1 327.7 252.5 145.8 212.2 278.0 161.0 203.2 162.9 388.0 285.5 296.6 311.0 397.6 181.6 269.2 289.6 286.0 234.2 308.5 387.6 283.6 174.1 291.7 234.9 194.9 273.8 240.9 185.6 771.4 127.1 170.5 199.1 295.2 188.2 234.2 139.6 288.1 217.9 286.3 541.8 249.7 226.5 171.2 299.7 537.0 452.5 467.1 523.2 459.8 442.6 218.4 476.7 434.4 450.4 360.3 419.9 549.4 633.1 534.2 505.1 328.6 367.1 483.2 625.3 579.3 574.5 526.2 683.0 678.6 674.5 403.8 662.9 418.6 421.3 262.4 459.8 547.4 359.2 478.2 340.1 676.8 471.7 633.0 485.0 474.3 868.7 376.1 653.6 465.4 366.7 598.0 888.7 714.7 269.7 527.7 447.4 470.4 728.0 798.4 370.1 414.9 503.7 459.3 412.8 344.6 395.5 539.5 452.8 788.4 938.8 551.5 1002.9 606.4 298.4 590.2 394.0 484.7 553.7 459.2 483.6 478.2 577.3 717.4 374.6 406.8 466.8 202.5 551.1 456.9 1378.2 874.4 1060.8 283.5 290.0 292.9 403.4 285.5 296.6 289.6 286.0 291.7 295.2 288.1 299.7 243.6 131.4 157.1 23.2 211.8 208.9 402.4 677.7 200.9 196.2 342.0 381.8 453.3 257.4 318.5 248.3 79.2 553.0 382.3 131.1 851.0 504.3 32.1 272.1 263.9 241.7 238.0 177.1 19.5 478.4 612.1 302.3 146.3 195.9 206.5 291.2 183.1 368.1 435.1 186.7 22.9 279.6 484.2 204.5 304.5 53.6 358.2 258.9 359.3 21.5 605.4 816.4 327.5 18.1 36.0 378.9 186.9 378.7 269.7 523.4 227.1 941.5 327.8 235.5 276.1 277.8 342.6 288.2 302.2 220.4 143.8 469.6 244.4 535.3 312.2 433.1 PARS2 DKFZp727A071 ENSG00000162396 "Prolyl-tRNA synthetase 2, mitochondrial" Q7L3T8 1 54756898-54764523 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Protein biosynthesis" "Aminoacyl-tRNA synthetase, Ligase" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal tubular cells: 9.8;Early spermatids: 11.0;Spermatocytes: 10.5;Spermatogonia: 11.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028308, HPA028314, HPA028518" Uncertain Approved "Nucleoli fibrillar center,Mitochondria" No No "Cluster 27: Non-specific - Gene expression" "Cluster 80: Striated muscle - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" "Nucleoli fibrillar center, Mitochondria" "HPA028308: AB_2672553, HPA028314: AB_10603981, HPA028518: AB_2672653" "unprognostic (1.95e-1)" "unprognostic (1.10e-1)" "prognostic favorable (1.26e-5)" "unprognostic (1.93e-2)" "unprognostic (1.19e-2)" "unprognostic (1.79e-3)" "prognostic unfavorable (2.34e-4)" "unprognostic (6.48e-2)" "unprognostic (2.72e-1)" "unprognostic (1.14e-1)" "unprognostic (9.42e-2)" "unprognostic (1.10e-1)" "prognostic favorable (1.24e-6)" "unprognostic (2.72e-2)" "unprognostic (9.77e-2)" "unprognostic (1.73e-2)" "unprognostic (9.64e-2)" 1.3 2.9 2.5 1.9 3.0 0.2 2.7 2.8 3.1 2.7 3.0 4.0 2.7 2.5 3.2 2.7 4.4 1.6 3.0 2.6 2.6 4.2 3.4 1.4 2.0 2.5 2.7 4.8 2.3 4.7 2.1 2.5 2.7 2.3 3.6 2.0 3.3 2.8 4.4 2.9 2.1 2.0 2.7 1.8 2.5 4.8 2.7 2.6 2.9 5.5 2.4 2.1 2.0 3.0 4.4 7.2 4.6 6.0 5.5 4.6 10.3 3.7 4.5 6.4 4.6 8.3 2.8 7.7 5.6 3.3 9.3 6.9 8.3 5.8 4.7 5.0 7.5 7.4 4.0 6.2 8.5 4.3 2.5 5.0 8.8 8.3 7.4 5.5 4.8 8.4 13.2 1.0 4.9 4.6 6.1 5.7 10.6 8.3 9.1 4.6 9.0 9.0 5.4 3.2 4.7 4.8 5.3 6.9 9.7 8.7 3.9 5.5 2.6 4.8 4.9 6.8 4.7 7.3 6.6 3.0 3.6 5.1 2.8 1.2 5.3 4.5 4.8 7.7 5.9 4.9 5.3 5.3 7.3 5.5 7.8 5.3 0.5 7.4 10.7 5.9 8.2 5.0 2.5 3.0 2.8 3.1 2.6 2.6 2.5 2.7 2.7 2.7 2.7 3.0 0.6 0.0 1.1 0.3 1.0 0.6 0.9 2.0 1.8 2.6 1.3 1.9 1.5 2.8 1.8 0.0 0.0 7.0 0.2 2.4 9.8 4.5 11.0 1.1 1.4 0.8 0.0 0.0 0.9 2.8 3.9 1.3 1.5 0.6 0.0 2.9 0.0 2.3 3.1 5.0 1.1 2.8 0.0 1.2 0.3 6.8 3.7 0.8 0.0 2.8 1.1 3.2 0.0 0.5 1.6 1.9 1.5 3.0 0.3 1.8 1.5 6.5 1.0 1.9 0.0 1.3 1.1 10.5 11.5 2.0 1.0 3.3 0.7 5.1 3.5 0.8 PAX6 "AN, AN1, AN2, D11S812E, WAGR" ENSG00000007372 "Paired box 6" P26367 11 31784779-31817961 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors" "Differentiation, Transcription, Transcription regulation" "Developmental protein, DNA-binding, Repressor" "Disease variant, Peters anomaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 61.6;retina: 68.9" "Group enriched" "Detected in some" 4 "Horizontal cells: 264.2;Muller glia cells: 462.6" "Cancer enhanced" "Detected in some" "glioma: 2.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 15.1;AN3-CA: 20.1;HEK 293: 18.0;HeLa: 14.9;hTERT-RPE1: 50.6;U-251 MG: 16.5" "Region enhanced" "Detected in all" "cerebellum: 54.3" "Low region specificity" "Detected in all" "HPA030775, CAB034143" Enhanced Supported Enhanced Nucleoplasm NA NA "Cluster 77: Retina - Visual perception" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 5: Muller glia cells - Visual perception" Nucleoplasm "CAB034143: AB_1127044, HPA030775: AB_10601243" "unprognostic (2.89e-1)" "unprognostic (2.98e-2)" "unprognostic (8.34e-2)" "unprognostic (3.85e-2)" "unprognostic (4.42e-2)" "unprognostic (7.82e-2)" "unprognostic (2.76e-1)" "unprognostic (1.91e-1)" "unprognostic (4.24e-3)" "unprognostic (1.68e-1)" "unprognostic (1.20e-2)" "unprognostic (3.91e-1)" "unprognostic (8.96e-2)" "unprognostic (1.32e-1)" "unprognostic (1.76e-1)" "unprognostic (1.57e-1)" "unprognostic (3.42e-3)" 0.0 0.6 21.7 0.0 22.9 0.2 0.1 61.6 34.1 0.0 16.5 0.2 1.7 0.0 0.6 0.0 0.0 0.0 0.0 23.6 20.7 0.8 0.1 0.0 0.0 22.0 18.1 0.0 9.2 0.0 4.3 0.0 21.7 0.0 0.3 68.9 0.1 0.0 0.8 0.5 0.9 0.0 21.4 0.0 9.4 1.6 19.6 0.4 0.0 0.0 0.1 0.1 0.1 25.8 0.0 0.2 15.1 20.1 4.6 6.6 5.9 0.0 0.0 0.2 0.0 1.3 3.7 0.1 6.3 2.3 9.0 0.4 1.8 0.0 0.3 0.0 18.0 8.9 14.9 8.4 0.0 0.5 0.0 0.1 0.7 0.1 0.5 50.6 0.0 5.2 7.6 0.0 0.2 0.0 3.7 0.6 0.3 0.0 10.1 0.0 7.3 0.1 0.8 0.6 0.7 0.0 0.4 0.1 0.0 0.0 4.7 0.0 0.0 5.3 0.4 0.0 16.5 0.1 0.2 0.1 8.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 21.7 22.9 61.6 34.1 23.6 20.7 22.0 18.1 21.7 21.4 19.6 25.8 0.2 0.0 0.0 76.7 0.1 0.5 0.0 0.0 0.0 78.8 0.5 0.0 3.8 0.0 0.0 0.0 12.5 0.1 0.1 0.2 0.0 0.0 0.7 0.2 0.5 1.0 74.6 0.0 3.6 0.0 0.3 0.4 0.0 0.4 0.0 0.0 0.0 0.0 0.1 264.2 1.6 3.1 0.0 0.0 0.4 0.6 0.0 0.2 0.0 3.7 0.6 462.6 0.0 3.5 0.6 2.5 1.3 0.0 0.0 0.0 0.1 0.2 0.0 30.6 0.0 0.9 0.5 21.4 7.5 0.0 0.0 0.0 0.1 0.1 0.2 0.0 PCARE "C2orf71, FLJ34931, RP54" ENSG00000179270 "Photoreceptor cilium actin regulator" A6NGG8 2 29060976-29074523 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Sensory transduction, Vision" "Ciliopathy, Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 19 "retina: 28.5" "Cell type enriched" "Detected in single" 20 "Cardiomyocytes: 2.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 43: Cardiomyocytes - Nuclear processes" "unprognostic (2.28e-3)" "unprognostic (1.23e-1)" "unprognostic (1.13e-1)" "unprognostic (3.15e-1)" "unprognostic (1.88e-1)" "unprognostic (5.88e-3)" "unprognostic (6.68e-3)" "unprognostic (1.21e-1)" "unprognostic (6.61e-2)" "unprognostic (3.81e-2)" "unprognostic (2.37e-1)" "unprognostic (2.08e-1)" "unprognostic (1.64e-1)" "unprognostic (2.28e-4)" 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.1 0.1 0.0 1.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.5 0.1 0.5 0.4 0.0 0.1 0.0 0.2 0.3 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 28.5 0.0 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.0 0.2 0.2 0.0 0.0 0.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.1 0.1 0.5 0.2 0.3 0.1 0.2 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PCDH15 "CDHR15, DFNB23, USH1F" ENSG00000150275 "Protocadherin related 15" Q96QU1 10 53802771-55627942 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion, Hearing" "Deafness, Disease variant, Non-syndromic deafness, Retinitis pigmentosa, Usher syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "adrenal gland: 19.0;brain: 21.2;retina: 61.7" "Cell type enriched" "Detected in some" 13 "Oligodendrocyte precursor cells: 2965.2" "Cancer enriched" "Detected in single" 9 "glioma: 0.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "U-2 OS: 1.1;U-266/70: 3.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA074437 Supported "Intracellular and membrane" NA NA 22000 "Cluster 77: Retina - Visual perception" "Cluster 29: U-266 - Adaptive immune response" "Cluster 68: Oligodendrocytes - Mixed function" "HPA074437: " "unprognostic (1.38e-1)" "unprognostic (3.39e-1)" "unprognostic (8.15e-5)" "unprognostic (3.07e-3)" "unprognostic (2.79e-1)" "unprognostic (9.15e-4)" "unprognostic (2.02e-1)" "unprognostic (3.89e-2)" "unprognostic (1.12e-3)" "unprognostic (1.31e-3)" "unprognostic (1.19e-1)" "unprognostic (1.34e-1)" "unprognostic (3.27e-1)" "unprognostic (7.66e-3)" 0.2 19.0 13.4 0.3 9.5 0.1 0.0 3.1 10.3 0.2 0.0 0.1 0.2 0.1 0.5 0.1 0.1 0.1 0.5 16.6 19.6 8.0 0.0 2.5 0.4 13.8 13.7 0.0 0.0 0.5 4.7 0.2 12.6 0.2 0.0 61.7 0.1 0.0 0.0 0.1 0.2 0.0 9.7 0.7 0.3 3.3 21.2 0.1 0.0 0.0 0.5 0.5 0.0 6.2 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.6 1.1 0.0 0.0 3.3 0.3 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.4 9.5 3.1 10.3 16.6 19.6 13.8 13.7 12.6 9.7 21.2 6.2 0.0 0.0 0.0 14.4 0.0 0.3 0.0 0.0 0.0 5.1 0.6 0.0 4.8 0.0 0.0 0.0 87.6 0.0 0.0 0.0 0.0 0.0 26.1 0.0 0.1 0.3 0.0 0.0 27.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 216.2 0.1 0.0 0.0 0.0 7.5 0.0 0.1 0.0 3.7 0.0 4.4 0.0 2965.2 2.5 0.0 0.0 0.0 0.0 0.0 0.0 3.1 0.0 92.8 0.0 0.0 0.2 0.3 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 PCDH19 "EFMR, EIEE9, KIAA1313" ENSG00000165194 "Protocadherin 19" Q8TAB3 X 100291644-100410273 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 11 "brain: 21.5" "Cell type enhanced" "Detected in many" "Adipocytes: 29.9;Excitatory neurons: 24.5;Inhibitory neurons: 51.8;Oligodendrocyte precursor cells: 40.7" "Cancer enhanced" "Detected in many" "endometrial cancer: 3.6;ovarian cancer: 3.6" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 6 "AF22: 18.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027533 Approved Approved Cytosol NA NA 83000 "Cluster 65: Brain - Ion transport" "Cluster 12: NES - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "HPA027533: AB_10602043" "unprognostic (7.38e-2)" "unprognostic (1.28e-1)" "unprognostic (2.92e-1)" "unprognostic (5.04e-2)" "unprognostic (2.13e-1)" "unprognostic (2.12e-1)" "unprognostic (1.96e-1)" "unprognostic (4.77e-2)" "unprognostic (3.64e-2)" "unprognostic (1.36e-2)" "unprognostic (2.53e-1)" "unprognostic (2.79e-1)" "unprognostic (9.77e-3)" "unprognostic (2.82e-3)" "unprognostic (1.53e-1)" "unprognostic (1.80e-4)" "unprognostic (1.37e-1)" 1.8 0.1 6.8 0.2 7.6 0.0 1.7 0.0 10.7 1.6 0.0 1.3 0.2 1.1 0.2 0.8 0.6 0.4 0.3 10.7 12.0 0.2 0.0 0.1 0.2 0.6 1.3 1.0 0.1 0.1 0.7 0.1 4.1 0.2 1.7 1.8 0.6 0.3 0.4 0.9 0.4 0.9 0.0 0.0 0.5 0.6 21.5 0.8 0.2 0.9 0.0 0.8 0.6 0.0 0.0 0.0 18.0 0.2 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.2 3.2 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.3 0.5 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.2 0.0 0.0 2.1 0.2 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.4 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.8 7.6 0.0 10.7 10.7 12.0 0.6 1.3 4.1 0.0 21.5 0.0 29.9 0.0 0.5 13.4 0.0 3.1 0.1 0.9 4.6 12.9 0.5 0.8 1.8 7.2 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.7 1.4 6.2 11.3 1.8 0.0 24.5 0.0 0.1 2.9 0.0 1.4 0.0 2.5 1.1 0.0 0.1 0.0 51.8 0.1 0.0 0.3 3.4 2.2 3.4 0.1 0.0 7.5 0.0 1.9 0.0 40.7 2.2 0.1 0.1 0.4 0.0 0.4 0.0 0.2 1.3 1.9 0.0 5.9 7.8 0.1 1.5 1.0 1.6 0.0 0.2 0.7 0.0 0.1 PCNA ENSG00000132646 "Proliferating cell nuclear antigen" P12004 20 5114953-5126626 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication, Host-virus interaction" DNA-binding "Cancer-related genes, Deafness, Disease variant, Dwarfism, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 383.2" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000148, HPA030521, HPA030522, HPA030523" Enhanced Enhanced Nucleoplasm No Yes 170000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "CAB000148: AB_628110, HPA030521: AB_10600218, HPA030522: AB_10602096, HPA030523: AB_10602199" "unprognostic (5.21e-2)" "prognostic favorable (1.86e-5)" "unprognostic (2.96e-2)" "unprognostic (2.43e-1)" "unprognostic (3.17e-1)" "unprognostic (5.60e-3)" "prognostic unfavorable (2.61e-4)" "unprognostic (1.47e-2)" "unprognostic (2.22e-1)" "unprognostic (3.89e-2)" "unprognostic (1.01e-2)" "unprognostic (9.78e-2)" "prognostic unfavorable (3.03e-6)" "unprognostic (2.12e-2)" "unprognostic (2.29e-1)" "unprognostic (7.11e-3)" "unprognostic (7.46e-2)" 31.2 47.2 23.2 85.2 26.0 383.2 51.0 26.8 29.7 41.5 26.8 89.0 70.7 38.1 30.9 81.2 39.1 34.8 30.6 23.0 24.4 43.7 55.3 37.5 168.8 25.1 24.0 37.7 32.8 42.4 25.1 69.8 26.0 32.2 93.7 94.1 40.3 38.3 27.9 62.8 72.9 47.9 26.8 54.0 53.9 62.3 23.3 219.9 42.0 26.8 137.3 51.0 42.3 30.0 769.1 591.4 585.0 253.7 136.1 126.6 409.5 491.6 288.3 453.7 640.0 465.3 594.2 773.4 155.7 177.5 395.2 558.8 350.7 594.4 413.2 231.7 386.8 543.7 207.8 1098.3 57.8 753.7 233.0 92.6 138.2 387.2 91.7 95.3 263.3 503.6 493.9 631.2 449.7 278.3 1450.6 829.3 439.9 592.0 322.9 787.9 514.1 622.5 208.5 441.1 500.8 339.4 345.1 524.6 351.9 213.9 371.2 378.0 177.2 324.3 373.3 461.5 572.0 317.2 981.6 1313.9 145.9 707.4 426.2 5.0 23.2 18.5 36.5 23.3 45.7 33.5 45.7 37.1 32.6 29.2 41.6 37.3 7.7 43.6 24.7 29.9 48.1 36.7 23.2 26.0 26.8 29.7 23.0 24.4 25.1 24.0 26.0 26.8 23.3 30.0 32.4 44.8 26.0 2.9 40.6 67.7 44.4 121.4 44.3 42.1 27.5 45.2 14.5 21.5 60.5 58.8 27.1 171.5 44.3 42.9 60.7 51.6 176.0 30.2 21.4 34.8 19.9 189.0 4.3 39.6 175.6 38.7 21.9 27.7 22.7 53.1 29.6 27.1 96.7 32.0 5.9 53.9 75.3 24.2 33.4 109.1 36.1 32.7 37.4 3.7 47.6 74.0 23.7 4.0 13.5 28.3 20.3 40.3 56.6 23.3 33.3 46.1 44.1 97.1 52.6 29.2 46.1 149.1 101.1 65.5 49.7 66.4 48.6 29.6 84.5 40.4 PCYT2 ET ENSG00000185813 "Phosphate cytidylyltransferase 2, ethanolamine" Q99447 17 81900958-81911432 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Nucleotidyltransferase, Transferase" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 165.7;testis: 261.7" "Group enriched" "Detected in many" 7 "Early spermatids: 763.2;Late spermatids: 2829.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Hep G2: 218.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023033, HPA023034" Enhanced Approved Nucleoplasm,Cytosol NA NA 84000 "Cluster 26: Non-specific - Mitochondria" "Cluster 78: Testis - Spermatogenesis" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 25: Spermatids - Spermatogenesis" Cytosol Nucleoplasm "HPA023033: AB_1855094, HPA023034: AB_1855095" "unprognostic (4.05e-3)" "unprognostic (4.39e-3)" "unprognostic (3.81e-1)" "unprognostic (9.72e-2)" "unprognostic (1.92e-1)" "unprognostic (9.86e-2)" "unprognostic (1.24e-2)" "unprognostic (1.06e-1)" "unprognostic (4.24e-1)" "unprognostic (8.97e-3)" "unprognostic (1.84e-1)" "unprognostic (2.34e-1)" "prognostic favorable (4.29e-6)" "unprognostic (1.19e-1)" "unprognostic (8.59e-2)" "unprognostic (1.63e-1)" "unprognostic (4.47e-2)" 29.7 16.8 40.0 9.5 40.1 12.1 25.2 44.4 45.8 14.9 30.4 25.5 63.9 18.0 13.5 26.3 23.9 9.9 47.7 41.2 37.7 44.0 165.7 21.3 12.0 47.0 43.0 20.9 25.3 20.2 14.4 12.0 47.3 24.2 16.7 8.6 22.3 12.1 33.5 16.3 43.0 9.6 41.3 12.8 35.4 261.7 41.0 13.5 16.2 29.3 11.9 21.2 15.1 44.0 42.6 23.9 18.8 53.1 91.8 48.0 27.9 29.9 63.2 40.7 48.0 94.0 43.0 14.8 16.0 31.1 75.3 34.5 28.6 55.1 23.5 4.5 24.3 32.1 33.3 218.2 97.8 32.5 26.0 39.8 31.4 36.8 28.4 14.5 38.6 44.0 60.6 29.6 30.8 35.7 39.3 40.1 15.1 147.2 25.9 25.4 20.2 52.4 49.2 78.8 23.9 21.9 22.4 121.7 29.0 36.5 33.9 75.3 26.1 30.0 19.7 22.9 25.0 19.3 9.1 15.3 31.2 42.8 29.9 1.5 2.4 0.9 4.6 2.6 3.0 4.2 5.5 4.7 4.5 5.6 4.5 4.6 0.7 3.3 2.1 4.4 3.6 3.1 40.0 40.1 44.4 45.8 41.2 37.7 47.0 43.0 47.3 41.3 41.0 44.0 11.5 0.0 17.3 15.0 11.1 5.4 8.1 11.7 6.8 12.5 25.1 11.0 17.0 62.9 9.6 25.8 0.0 73.1 21.0 41.6 119.3 19.5 763.2 29.0 7.5 8.7 13.9 47.8 5.3 18.3 39.7 7.7 36.2 15.8 9.5 39.6 21.8 166.0 24.1 16.8 4.6 29.1 20.3 11.8 3.3 2829.0 27.7 8.1 33.8 0.0 14.7 26.7 22.6 3.5 12.2 17.8 18.8 25.9 13.4 11.4 144.4 130.3 29.4 10.6 26.3 6.2 11.5 253.1 18.1 16.5 5.7 50.8 13.6 34.4 48.7 7.7 PDCD1 "CD279, hSLE1, PD-1, PD1, SLEB2" ENSG00000188389 "Programmed cell death 1" Q15116 2 241849884-241858894 "CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Adaptive immunity, Apoptosis, Immunity" "FDA approved drug targets, Systemic lupus erythematosus" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "heart muscle: 6.7;lymphoid tissue: 16.1" "Group enriched" "Detected in some" 4 "Plasma cells: 9.5;T-cells: 34.7" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in single" "midbrain: 1.4" "Group enriched" "Detected in many" 5 "gdT-cell: 4.4;MAIT T-cell: 4.8;memory CD4 T-cell: 8.7;memory CD8 T-cell: 12.4;T-reg: 4.3" "Lineage enriched" "Detected in single" 55 "T-cells: 12.4" "Cell line enhanced" "Detected in some" "JURKAT: 1.5;MOLT-4: 2.4;RPMI-8226: 6.9" "Not detected" "Not detected" "Not detected" "Not detected" "HPA035981, CAB038418, CAB076386" Enhanced NA NA "Cluster 20: T-cells - T-cell receptor" "Cluster 16: Immune cells - Immune response" "Cluster 25: RPMI-8226 - Immune response" "Cluster 24: Non-specific - Transcription regulation" "CAB038418: AB_1160824, CAB076386: AB_881954, HPA035981: AB_10669664" "unprognostic (2.90e-3)" "unprognostic (4.50e-3)" "unprognostic (7.78e-2)" "prognostic favorable (9.44e-5)" "unprognostic (7.18e-3)" "unprognostic (1.31e-3)" "unprognostic (3.83e-2)" "unprognostic (7.33e-2)" "unprognostic (5.82e-3)" "unprognostic (3.75e-2)" "unprognostic (6.57e-2)" "unprognostic (3.94e-1)" "prognostic unfavorable (3.48e-7)" "unprognostic (1.20e-2)" "unprognostic (3.10e-1)" "unprognostic (5.35e-2)" "unprognostic (5.06e-3)" 1.2 0.3 0.0 3.2 0.2 0.9 0.4 0.0 0.1 0.6 0.2 0.8 0.3 0.4 0.0 0.8 0.6 0.3 6.7 0.1 0.1 0.7 0.4 1.8 16.1 0.1 1.4 0.2 0.3 0.0 1.5 0.0 0.2 0.7 0.1 0.0 1.0 0.2 0.1 0.3 3.8 0.2 0.1 7.0 1.8 0.3 0.4 3.1 1.5 0.0 4.0 1.0 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.3 0.0 0.0 0.3 2.4 0.0 0.0 0.0 0.0 0.0 0.1 6.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.4 0.0 4.8 0.2 8.7 12.4 0.0 0.0 0.8 1.2 0.0 0.0 0.0 0.0 4.3 2.1 0.0 0.2 0.0 0.1 0.1 0.1 0.1 1.4 0.2 0.1 0.4 0.2 0.4 0.0 0.6 0.0 3.6 0.4 0.3 0.0 0.0 0.0 0.3 0.5 0.6 0.0 0.0 0.0 0.0 0.0 3.7 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 5.3 0.0 0.0 0.0 0.3 1.1 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.3 1.4 0.0 0.0 1.3 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.5 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.3 0.0 0.0 0.1 0.6 0.0 34.7 0.0 0.0 0.1 PDE10A ENSG00000112541 "Phosphodiesterase 10A" Q9Y233 6 165327287-165988078 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Allosteric enzyme, Hydrolase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 11 "brain: 67.2" "Cell type enhanced" "Detected in many" "Excitatory neurons: 204.7;Inhibitory neurons: 209.6;Microglial cells: 89.0;Oligodendrocyte precursor cells: 48.7;Oligodendrocytes: 51.8" "Low cancer specificity" "Detected in many" "Region enriched" "Detected in many" 6 "basal ganglia: 67.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HeLa: 9.0;LHCN-M2: 12.5;RT4: 6.9;SH-SY5Y: 8.1;TIME: 11.3;U-2 OS: 7.0" "Region enriched" "Detected in all" 11 "basal ganglia: 350.1" "Region enriched" "Detected in all" 5 "basal ganglia: 194.1" "CAB045998, HPA047200" Supported NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB045998: AB_2162589, HPA047200: AB_2679981" "unprognostic (1.02e-1)" "unprognostic (3.63e-2)" "unprognostic (3.58e-2)" "unprognostic (2.91e-1)" "unprognostic (1.20e-1)" "unprognostic (1.25e-1)" "unprognostic (1.76e-1)" "unprognostic (1.23e-1)" "unprognostic (9.36e-2)" "unprognostic (6.03e-2)" "unprognostic (3.79e-2)" "unprognostic (9.24e-2)" "prognostic unfavorable (4.44e-7)" "unprognostic (3.59e-3)" "unprognostic (2.37e-2)" "unprognostic (3.44e-2)" "unprognostic (5.90e-3)" 2.6 1.3 3.1 0.8 67.2 0.0 2.3 5.5 10.7 1.3 0.0 1.0 0.2 2.0 2.4 0.4 2.4 1.5 3.6 2.1 2.5 3.8 0.3 1.0 0.5 1.6 2.3 2.3 0.5 0.5 2.7 2.5 0.9 1.7 0.2 1.9 0.4 1.7 0.4 0.3 0.7 2.1 0.5 1.4 1.1 3.4 9.6 0.3 6.0 0.5 0.4 3.2 0.9 0.1 0.0 2.4 5.5 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 6.3 0.8 0.0 0.0 0.0 3.8 0.1 2.2 0.0 0.0 0.1 3.9 0.0 9.0 0.0 0.4 0.0 0.0 0.0 0.0 0.6 0.0 0.0 5.5 0.0 0.0 0.0 12.5 0.3 0.9 0.0 1.1 0.0 4.7 1.5 5.8 0.0 5.9 6.9 1.8 8.1 0.0 0.0 0.4 0.7 0.0 0.0 11.3 0.1 7.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 3.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.1 67.2 5.5 10.7 2.1 2.5 1.6 2.3 0.9 0.5 9.6 0.1 13.8 0.0 0.0 10.4 0.1 0.4 3.3 0.4 0.0 7.2 0.3 0.3 7.3 0.0 1.2 5.5 2.1 7.8 0.0 0.0 3.9 2.0 14.3 0.2 1.7 13.4 0.0 0.0 204.7 0.0 6.1 6.6 1.1 0.4 1.3 0.1 7.9 0.0 0.8 16.8 209.6 0.0 0.0 0.0 0.0 14.9 0.0 0.2 1.8 89.0 0.0 12.6 0.0 48.7 51.8 0.1 0.0 0.4 0.0 17.9 0.0 7.2 0.9 1.1 0.0 12.4 5.0 8.8 2.1 0.1 0.3 2.9 0.1 1.6 0.1 6.9 PDE1C Hcam3 ENSG00000154678 "Phosphodiesterase 1C" Q14123 7 31751179-32428131 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Calmodulin-binding, Hydrolase" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "brain: 68.9;heart muscle: 58.5" "Cell type enriched" "Detected in many" 5 "Oligodendrocytes: 1071.4" "Cancer enhanced" "Detected in some" "glioma: 1.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ: 44.4;fHDF/TERT166: 148.3;hTERT-RPE1: 44.9;U-251 MG: 77.9;WM-115: 105.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA052375 Approved Nucleoplasm NA NA "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA052375: AB_2681802" "unprognostic (1.29e-2)" "unprognostic (2.20e-5)" "unprognostic (1.68e-2)" "unprognostic (1.20e-3)" "unprognostic (2.29e-1)" "unprognostic (5.65e-2)" "unprognostic (4.06e-3)" "unprognostic (2.75e-1)" "unprognostic (6.79e-3)" "unprognostic (6.49e-2)" "unprognostic (3.88e-5)" "unprognostic (7.03e-2)" "unprognostic (3.09e-3)" "unprognostic (5.76e-2)" "unprognostic (5.80e-2)" "unprognostic (1.49e-1)" "unprognostic (1.06e-3)" 2.4 1.8 19.2 2.5 43.0 0.0 4.3 21.4 39.9 0.7 0.0 3.0 1.4 2.4 6.0 6.4 10.5 1.5 58.5 18.9 24.2 4.2 0.1 4.9 0.6 29.4 27.9 3.8 2.6 0.3 1.3 3.2 27.7 2.0 1.8 7.4 1.8 3.2 0.6 0.4 3.3 5.0 16.4 0.6 4.0 3.8 28.6 1.6 3.1 4.0 0.1 9.8 1.4 68.9 0.3 5.8 15.5 0.0 0.6 0.4 0.2 44.4 18.3 20.8 17.1 0.0 0.0 0.0 0.2 148.3 0.0 1.2 0.0 0.0 27.1 0.0 0.0 1.3 1.4 0.0 0.1 0.0 31.9 1.9 0.0 4.3 0.2 44.9 7.1 0.0 0.1 0.1 1.7 0.0 0.1 0.0 0.0 0.0 13.7 0.0 0.0 0.0 22.5 0.0 6.8 0.0 0.0 0.0 0.0 1.3 0.0 0.3 0.2 22.8 8.6 0.4 77.9 0.4 0.0 0.0 2.4 0.5 105.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.2 43.0 21.4 39.9 18.9 24.2 29.4 27.9 27.7 16.4 28.6 68.9 1.2 0.0 0.0 7.5 0.1 0.0 0.7 0.1 1.2 69.5 2.8 17.1 136.0 0.0 0.7 1.8 52.1 0.0 0.1 0.0 0.0 4.8 53.4 0.2 0.1 3.9 0.0 0.0 70.8 0.4 0.0 8.7 0.0 0.4 8.8 0.2 0.0 0.0 0.1 3.3 169.2 0.0 59.0 0.0 0.2 50.3 0.3 0.5 0.0 15.9 0.0 0.9 0.0 196.6 1071.4 0.2 0.0 0.4 0.1 0.2 0.0 0.0 2.2 4.7 0.0 0.9 9.4 1.3 1.2 0.2 0.0 0.0 0.1 1.2 0.0 0.0 PDE6A "PDEA, RP43" ENSG00000132915 "Phosphodiesterase 6A" P16499 5 149857953-149944793 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Sensory transduction, Vision" Hydrolase "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 68 "retina: 1119.5" "Cell type enriched" "Detected in many" 11 "Rod photoreceptor cells: 2946.4" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Immune cell enhanced" "Detected in single" "basophil: 1.1" "Low lineage specificity" "Detected in single" "Cell line enriched" "Detected in single" 5 "CACO-2: 2.5" "Not detected" "Not detected" "Not detected" "Not detected" "HPA016970, HPA074677" Enhanced NA NA "Cluster 11: Basophils - Unknown function" "Cluster 79: Retina - Phototransduction" "Cluster 39: CACO-2 - Unknown function" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA016970: AB_1855125, HPA074677: AB_2732264" "unprognostic (6.85e-2)" "unprognostic (8.84e-2)" "unprognostic (1.70e-2)" "unprognostic (4.11e-2)" "unprognostic (1.12e-2)" "unprognostic (5.72e-2)" "unprognostic (4.39e-3)" "unprognostic (8.83e-2)" "unprognostic (6.54e-2)" "unprognostic (5.91e-3)" "unprognostic (1.77e-2)" "unprognostic (9.21e-2)" "unprognostic (7.57e-5)" "unprognostic (9.93e-2)" "unprognostic (3.08e-1)" "unprognostic (1.31e-1)" "unprognostic (2.26e-2)" 0.1 0.7 0.5 0.2 0.5 0.9 0.2 1.4 0.7 0.1 0.2 1.2 0.2 0.1 16.3 0.9 0.2 0.2 0.2 0.5 0.5 0.1 0.1 0.3 0.1 0.3 0.3 0.2 0.2 0.2 1.7 0.1 0.5 0.3 0.9 1119.5 0.4 0.2 0.3 0.6 0.1 0.1 0.2 0.2 0.2 1.5 0.6 0.0 0.4 0.0 0.2 0.0 0.1 1.2 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.1 0.0 2.5 0.2 0.3 0.4 0.0 0.4 0.2 0.0 0.1 0.1 0.1 0.0 0.2 0.4 0.2 0.0 0.2 0.1 0.0 0.3 0.3 0.2 0.2 0.0 0.0 0.1 0.4 0.4 0.1 0.1 0.2 0.1 0.0 0.1 0.0 0.1 0.1 0.1 0.3 0.2 0.3 0.0 0.2 0.0 0.1 0.3 0.1 0.4 0.2 0.4 0.1 0.1 0.2 0.1 0.1 0.2 0.2 0.1 1.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.3 0.1 0.1 0.6 0.2 0.1 0.2 0.1 0.0 0.5 0.5 1.4 0.7 0.5 0.5 0.3 0.3 0.5 0.2 0.6 1.2 0.9 0.0 5.8 0.0 0.4 1.1 0.6 0.8 0.0 150.5 0.5 0.4 6.7 0.0 2.8 0.0 244.0 1.1 1.6 14.3 0.0 0.1 18.4 1.5 0.5 11.6 0.0 0.0 1.2 0.2 2.2 1.2 0.0 2.5 3.8 1.9 2.2 0.6 0.3 75.7 0.6 0.4 2.0 1.9 0.4 5.5 1.2 1.5 0.0 0.0 1.4 263.1 5.2 0.5 0.2 0.1 2.8 0.4 0.3 0.4 0.4 0.1 3.2 2946.4 0.0 1.0 1.2 2.3 0.8 5.4 0.6 2.9 1.5 2.2 2.7 0.2 PDE6B "CSNB3, CSNBAD2, PDEB, rd1, RP40" ENSG00000133256 "Phosphodiesterase 6B" P35913 4 625573-670782 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Sensory transduction, Vision" Hydrolase "Congenital stationary night blindness, Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in many" 10 "retina: 385.0" "Cell type enriched" "Detected in many" 5 "Rod photoreceptor cells: 460.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "EFO-21: 11.5;JURKAT: 17.3;MOLT-4: 31.3;REH: 16.8;SCLC-21H: 20.2;SH-SY5Y: 11.9;U-266/84: 24.0" "Not detected" "Not detected" "Not detected" "Not detected" "HPA054148, HPA059929" Enhanced Approved Cytosol NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 77: Retina - Visual perception" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 46: Photoreceptor cells - Phototransduction" Cytosol "HPA054148: AB_2682401, HPA059929: AB_2684166" "unprognostic (2.43e-2)" "unprognostic (1.33e-4)" "unprognostic (2.45e-4)" "unprognostic (7.18e-3)" "unprognostic (1.88e-2)" "unprognostic (5.04e-3)" "unprognostic (7.32e-3)" "prognostic favorable (5.34e-4)" "unprognostic (9.70e-2)" "unprognostic (1.14e-1)" "unprognostic (1.37e-2)" "unprognostic (2.33e-2)" "unprognostic (4.09e-2)" "unprognostic (1.67e-2)" "unprognostic (2.26e-1)" "unprognostic (2.41e-3)" "unprognostic (1.85e-1)" 1.9 2.2 13.5 5.5 25.7 8.4 4.1 8.2 22.3 2.5 1.9 1.7 1.2 2.7 4.0 1.7 10.2 3.7 5.9 11.2 22.6 4.9 1.0 4.6 14.3 22.8 19.9 2.8 1.8 8.2 4.1 3.1 25.5 2.8 1.3 385.0 3.8 3.0 1.1 2.1 3.0 2.5 9.3 10.1 2.9 4.4 24.1 12.2 12.0 0.1 9.3 3.8 1.4 39.3 0.1 0.0 1.2 0.5 0.3 0.4 0.4 0.0 0.1 0.8 2.0 0.0 0.1 0.3 11.5 0.3 0.9 0.1 2.5 0.6 0.0 0.1 0.0 1.0 0.3 0.1 5.8 0.2 0.4 0.7 0.0 3.5 0.0 0.8 1.1 17.3 0.1 1.0 0.1 0.3 31.3 0.1 9.4 0.7 0.0 16.8 0.2 0.2 2.1 1.3 20.2 11.9 0.0 0.3 0.1 4.2 0.6 0.0 0.4 0.2 1.2 0.2 0.4 7.7 24.0 0.3 0.3 0.3 0.2 16.8 5.4 0.9 14.0 7.7 12.6 12.8 9.3 9.8 8.5 21.4 14.6 15.8 1.4 14.4 8.1 18.2 15.5 9.4 13.5 25.7 8.2 22.3 11.2 22.6 22.8 19.9 25.5 9.3 24.1 39.3 0.5 3.2 5.0 4.2 6.4 0.4 2.1 1.2 2.8 20.7 3.9 2.4 4.4 0.0 3.5 0.0 83.4 0.1 8.4 0.2 1.9 6.9 0.4 7.0 2.2 2.9 1.8 7.4 40.3 0.6 0.3 1.3 1.5 2.5 3.8 5.4 2.2 0.0 11.3 11.8 27.3 0.5 4.1 5.1 1.4 0.3 1.5 3.3 3.6 4.7 6.2 31.1 7.2 10.1 33.9 0.8 0.2 1.5 7.5 1.9 0.0 8.4 11.2 460.1 0.0 1.6 1.1 4.3 11.0 1.9 0.3 0.3 5.9 3.5 0.4 1.3 PDE6C "ACHM5, COD4, PDEA2" ENSG00000095464 "Phosphodiesterase 6C" P51160 10 93612537-93666010 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Sensory transduction, Vision" Hydrolase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 26 "retina: 23.1" "Cell type enriched" "Detected in some" 13 "Cone photoreceptor cells: 56.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 9: Photoreceptor cells - Phototransduction" "unprognostic (1.39e-3)" "unprognostic (7.41e-3)" "unprognostic (2.61e-2)" "unprognostic (2.24e-1)" "unprognostic (3.17e-2)" "unprognostic (5.23e-3)" "unprognostic (2.46e-3)" "unprognostic (2.81e-3)" "unprognostic (9.68e-2)" "unprognostic (2.64e-1)" "unprognostic (1.51e-2)" "unprognostic (2.96e-3)" "unprognostic (2.19e-7)" "unprognostic (1.19e-1)" "unprognostic (6.61e-2)" "unprognostic (1.81e-1)" "unprognostic (1.80e-3)" 0.1 0.1 0.2 0.0 0.2 0.2 0.1 0.8 0.3 0.3 0.0 0.1 0.0 0.1 0.0 0.1 0.2 0.0 0.1 0.2 0.2 0.1 0.1 0.1 0.1 0.2 0.0 0.2 0.1 0.0 0.2 0.0 0.2 0.2 0.0 23.1 0.1 0.0 0.5 0.5 0.1 0.0 0.0 0.1 0.1 0.1 0.4 0.0 0.1 0.0 0.0 0.2 0.2 0.5 0.0 0.1 0.0 0.2 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.8 0.3 0.2 0.2 0.2 0.0 0.2 0.0 0.4 0.5 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.3 0.0 0.0 0.0 56.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 1.0 0.0 0.7 0.0 0.5 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.2 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 PDE6G "PDEG, RP57" ENSG00000185527 "Phosphodiesterase 6G" P18545 17 81650459-81663112 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Sensory transduction, Vision" Hydrolase "Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 99 "retina: 2050.3" "Cell type enriched" "Detected in many" 6 "Rod photoreceptor cells: 4448.6" "Cancer enhanced" "Detected in many" "testis cancer: 10.6" "Not detected" "Not detected" "Group enriched" "Detected in many" 6 "basophil: 127.0;NK-cell: 220.2" "Group enriched" "Detected in all" 6 "granulocytes: 127.0;NK-cells: 220.2" "Cell line enhanced" "Detected in some" "Hep G2: 5.2;NB-4: 5.8;NTERA-2: 8.9;REH: 11.9;SuSa: 6.2" "Region enhanced" "Detected in some" "hippocampal formation: 4.7" "Not detected" "Not detected" HPA045118 Supported Uncertain Vesicles NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 79: Retina - Phototransduction" "Cluster 5: NTERA-2 - Transcription" "Cluster 46: Photoreceptor cells - Phototransduction" Vesicles "HPA045118: AB_2732517" "unprognostic (6.16e-2)" "unprognostic (1.95e-2)" "unprognostic (2.83e-2)" "unprognostic (3.51e-3)" "unprognostic (1.68e-1)" "unprognostic (1.46e-2)" "unprognostic (6.33e-2)" "unprognostic (3.80e-2)" "unprognostic (1.10e-2)" "unprognostic (1.02e-1)" "unprognostic (4.85e-2)" "unprognostic (5.01e-2)" "unprognostic (1.94e-2)" "unprognostic (5.71e-2)" "unprognostic (5.44e-2)" "unprognostic (2.73e-1)" "unprognostic (1.14e-1)" 1.5 0.3 0.0 4.7 0.1 7.8 0.9 0.2 0.5 1.0 0.2 1.6 0.6 0.2 0.1 0.8 0.7 2.5 0.4 0.1 0.7 2.1 4.2 3.0 20.6 0.1 0.2 0.0 0.0 0.1 0.1 12.0 0.2 0.2 1.0 2050.3 0.5 0.4 1.2 0.3 1.6 0.9 0.1 19.9 1.7 0.8 0.3 8.3 0.4 0.3 7.1 3.0 0.1 0.2 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.5 0.0 0.0 0.3 0.1 0.2 0.0 0.9 0.0 0.0 0.0 0.0 5.2 0.8 0.0 0.2 0.0 0.0 0.0 0.0 0.4 2.8 0.2 0.1 0.2 0.4 0.3 0.0 5.8 8.9 0.0 0.0 11.9 0.0 1.9 0.0 0.0 0.0 0.2 0.0 0.1 0.1 6.2 0.1 0.8 1.2 0.2 0.0 0.0 0.1 0.1 0.6 0.9 0.4 3.1 0.1 127.0 18.1 30.5 4.1 26.2 1.3 2.7 0.8 2.3 28.9 5.1 2.1 7.4 2.4 220.2 15.5 2.9 0.1 13.5 0.0 0.1 0.2 0.5 0.1 0.7 0.1 0.2 0.2 0.1 0.3 0.2 0.3 0.0 0.6 0.3 1.1 0.9 0.0 0.0 0.6 422.5 0.3 0.4 0.2 0.0 0.0 5.5 517.1 0.2 4.3 0.1 1.9 0.4 0.8 1.5 0.3 27.2 0.0 1.7 0.2 0.2 0.4 0.2 0.0 0.5 23.6 0.1 2.9 0.2 22.6 262.5 0.1 0.2 0.0 4.8 8.0 2.3 0.0 4.4 3.6 0.0 13.3 709.0 11.3 0.0 0.1 0.2 0.0 0.0 0.8 0.1 0.1 1.0 0.0 4448.6 0.0 0.1 0.1 1.1 0.2 0.3 1.4 0.3 1.7 2.1 0.0 0.1 PDE6H ENSG00000139053 "Phosphodiesterase 6H" Q13956 12 14973042-14981865 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Sensory transduction, Vision" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 226 "retina: 911.3" "Group enriched" "Detected in some" 6 "Cone photoreceptor cells: 831.9;Rod photoreceptor cells: 218.8" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "AN3-CA: 1.0" "Low region specificity" "Detected in single" HPA045118 Supported Uncertain Vesicles NA NA "Cluster 79: Retina - Phototransduction" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 9: Photoreceptor cells - Phototransduction" Vesicles "HPA045118: AB_2732517" "unprognostic (1.47e-3)" "unprognostic (1.07e-2)" 0.0 0.4 0.3 0.0 0.4 4.0 0.0 0.1 1.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 2.3 0.0 0.0 0.1 0.0 0.3 0.4 0.0 0.0 0.0 0.0 0.9 0.5 0.0 0.0 911.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.2 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.4 0.1 1.0 0.3 2.3 0.3 0.4 0.5 0.2 0.3 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 62.9 0.0 0.0 0.1 0.0 0.0 0.0 831.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.5 0.0 0.0 0.5 0.0 21.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.9 23.5 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.5 0.0 0.0 0.6 81.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 218.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 PDE8B ENSG00000113231 "Phosphodiesterase 8B" O95263 5 77210449-77428256 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" Hydrolase "Cushing syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "thyroid gland: 124.7" "Cell type enhanced" "Detected in many" "Astrocytes: 64.9;Excitatory neurons: 183.1;Horizontal cells: 69.0;Inhibitory neurons: 276.5;Muller glia cells: 86.5;Oligodendrocyte precursor cells: 190.5" "Cancer enriched" "Detected in many" 6 "thyroid cancer: 35.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ hTERT+: 13.6;HeLa: 34.8;SK-BR-3: 11.1" "HPA036911, HPA036912" Supported Approved Nucleoplasm,Cytosol NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 7: Kidney - Transmembrane transport" "Cluster 20: HeLa - Mitochondria" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Cytosol" "HPA036911: AB_2675378, HPA036912: AB_10670377" "unprognostic (1.30e-1)" "unprognostic (7.95e-2)" "unprognostic (3.35e-2)" "unprognostic (7.61e-4)" "unprognostic (1.59e-2)" "unprognostic (1.41e-1)" "unprognostic (2.66e-2)" "unprognostic (4.48e-2)" "unprognostic (1.71e-1)" "unprognostic (3.26e-2)" "unprognostic (3.98e-2)" "unprognostic (2.44e-1)" "unprognostic (9.04e-3)" "unprognostic (3.40e-2)" "unprognostic (3.76e-2)" "unprognostic (1.98e-1)" "unprognostic (3.19e-2)" 20.9 4.8 24.2 1.0 28.6 0.4 14.0 4.8 24.6 17.4 0.0 5.6 2.0 26.4 6.3 2.0 28.7 4.3 23.7 25.5 32.5 15.6 2.3 5.2 1.2 20.5 15.9 4.2 7.9 0.8 12.5 23.8 18.8 19.0 1.2 22.5 10.5 11.9 0.7 2.0 3.3 17.7 9.9 0.8 5.5 3.0 36.7 0.3 124.7 0.8 1.0 4.0 4.9 17.2 0.1 4.9 0.8 0.3 1.5 0.0 0.5 1.5 13.6 0.2 0.1 1.4 0.1 0.3 0.1 0.1 0.2 0.6 0.2 0.0 0.2 0.2 0.7 0.4 34.8 0.3 0.0 0.4 0.5 0.8 0.0 0.0 0.0 0.4 0.0 0.5 0.1 0.2 0.0 0.2 0.5 0.8 0.8 0.2 0.1 0.6 0.9 0.4 0.0 0.2 5.4 1.0 2.3 11.1 0.7 0.7 1.8 0.9 0.5 0.3 0.3 0.2 0.5 0.7 0.5 0.4 1.2 0.5 0.3 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 24.2 28.6 4.8 24.6 25.5 32.5 20.5 15.9 18.8 9.9 36.7 17.2 0.8 3.2 2.8 64.9 0.3 0.4 2.0 0.1 0.0 10.8 5.8 3.0 28.0 2.8 1.6 1.8 54.2 0.0 0.2 0.1 0.0 2.3 6.8 15.3 2.1 4.5 4.9 0.0 183.1 0.0 0.1 3.8 0.0 7.9 1.3 1.8 2.9 0.1 0.4 69.0 276.5 1.0 0.0 1.0 1.6 5.1 5.9 0.9 1.8 10.3 0.1 86.5 0.0 190.5 45.5 0.2 0.4 0.0 0.3 29.1 0.2 0.7 0.7 5.8 6.6 1.8 7.7 1.1 2.6 0.5 1.1 0.0 0.1 8.8 1.2 4.2 PDGFB "SIS, SSV" ENSG00000100311 "Platelet derived growth factor subunit B" P01127 22 39223359-39244982 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins" "Developmental protein, Growth factor, Mitogen" "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Adipocytes: 75.0;Endothelial cells: 60.6;Langerhans cells: 44.3;Macrophages: 25.5;Pancreatic endocrine cells: 54.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "MAIT T-cell: 10.0" "Lineage enriched" "Detected in many" 7 "T-cells: 10.0" "Cell line enhanced" "Detected in many" "A-431: 33.8;EFO-21: 69.2;HUVEC TERT2: 52.6;SK-BR-3: 53.5;TIME: 68.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011604, HPA011972, CAB018341" Supported Approved Vesicles "Secreted to blood" NA NA 4390000 950000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 38: EFO-21 - Unknown function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Vesicles "CAB011604: AB_2162180, CAB018341: AB_2162187, HPA011972: AB_1855134" "unprognostic (4.96e-2)" "unprognostic (8.94e-3)" "unprognostic (8.41e-2)" "unprognostic (2.66e-1)" "unprognostic (9.84e-2)" "unprognostic (4.46e-3)" "unprognostic (4.34e-1)" "prognostic unfavorable (3.67e-5)" "unprognostic (3.22e-2)" "unprognostic (2.07e-1)" "unprognostic (1.05e-1)" "unprognostic (8.68e-2)" "unprognostic (1.84e-3)" "unprognostic (5.12e-3)" "unprognostic (7.47e-2)" "unprognostic (6.50e-2)" "unprognostic (1.03e-1)" 32.6 6.4 14.7 7.1 10.7 0.4 24.0 10.3 22.2 7.5 4.8 20.6 4.9 8.9 5.2 6.2 7.2 11.7 31.2 12.0 9.8 17.0 3.7 28.1 7.4 13.6 12.4 3.8 8.8 8.9 4.0 40.2 12.0 7.6 3.5 0.8 10.6 5.2 18.7 10.3 9.1 9.2 10.6 6.6 7.9 3.4 16.0 2.1 16.1 11.0 1.6 8.5 6.6 9.4 33.8 2.6 8.4 0.0 0.0 0.0 9.9 0.1 0.4 0.2 0.0 13.0 10.3 0.0 69.2 0.0 3.1 12.4 0.5 2.8 0.0 0.1 0.2 0.7 1.1 4.8 4.3 0.0 18.1 0.0 0.3 0.0 0.4 0.9 52.6 0.0 1.3 6.1 1.9 13.7 0.1 0.1 3.2 8.1 3.4 0.0 0.3 22.8 27.7 0.1 0.2 0.0 0.6 53.5 0.2 6.0 24.3 0.1 68.1 0.1 6.4 0.1 7.5 0.1 0.4 0.3 0.1 1.5 31.3 0.0 0.0 0.0 7.3 0.1 10.0 0.0 4.3 5.6 0.0 0.0 3.6 1.9 0.1 0.0 0.4 1.3 2.3 2.1 14.7 10.7 10.3 22.2 12.0 9.8 13.6 12.4 12.0 10.6 16.0 9.4 75.0 0.0 1.1 0.0 0.6 2.8 1.2 3.8 1.2 0.7 5.1 7.1 3.1 0.0 1.3 7.3 0.0 7.3 4.0 0.1 0.0 20.0 1.3 4.0 0.7 60.6 1.8 0.0 2.8 3.6 6.5 1.6 0.0 5.6 0.0 13.1 16.8 1.4 7.7 0.0 0.9 0.7 4.1 2.6 44.3 0.1 0.6 25.5 1.8 14.0 1.1 0.3 0.0 0.0 0.2 54.7 0.0 0.0 0.0 2.7 0.1 1.9 0.9 0.1 6.6 4.7 9.6 0.3 1.6 1.1 1.4 4.5 2.0 1.2 0.1 0.6 PDGFRB "CD140b, JTK12, PDGFR, PDGFR1" ENSG00000113721 "Platelet derived growth factor receptor beta" P09619 5 150113839-150155872 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" Chemotaxis "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in many" 4 "Sertoli cells: 1288.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "non-classical monocyte: 1.6" "Low lineage specificity" "Detected in single" "Group enriched" "Detected in many" 4 "ASC diff: 1350.1;ASC TERT1: 462.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003842, CAB018144, HPA028499" Enhanced Supported "Golgi apparatus,Vesicles" NA NA 39000000 "Cluster 14: Monocytes - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 48: Smooth muscle cells - ECM organization" Vesicles "Golgi apparatus" "CAB003842: AB_562328, CAB018144: AB_2162497, HPA028499: AB_10602018" "unprognostic (4.75e-2)" "unprognostic (2.48e-1)" "unprognostic (5.21e-2)" "unprognostic (3.60e-2)" "unprognostic (3.27e-1)" "unprognostic (5.61e-2)" "unprognostic (1.02e-1)" "unprognostic (3.36e-2)" "unprognostic (2.12e-2)" "unprognostic (2.57e-3)" "unprognostic (6.72e-2)" "unprognostic (1.25e-1)" "prognostic unfavorable (5.87e-8)" "unprognostic (3.13e-3)" "unprognostic (1.25e-2)" "unprognostic (5.47e-2)" "prognostic unfavorable (8.11e-4)" 171.2 25.1 25.4 27.5 27.2 0.7 106.3 20.5 33.3 155.9 43.5 41.6 11.9 101.1 24.2 24.1 89.6 124.5 75.7 22.1 23.2 49.7 13.4 98.3 27.5 22.1 24.6 105.5 20.8 21.9 23.0 113.3 22.8 56.2 14.1 6.3 34.5 43.3 38.1 65.0 37.9 68.9 19.4 41.4 27.9 18.4 27.7 8.7 66.5 44.1 13.8 58.3 98.6 21.6 0.1 0.3 8.3 0.4 1350.1 462.7 3.0 48.9 202.3 33.5 56.4 5.4 0.0 0.0 6.4 142.0 19.0 0.1 0.1 0.4 15.8 0.0 0.0 0.1 3.3 3.5 190.7 0.0 0.4 210.0 0.0 46.3 0.6 106.6 0.1 0.1 0.1 5.5 5.5 0.0 0.1 0.6 9.0 0.2 0.2 3.7 2.5 0.2 0.0 0.0 0.1 24.8 0.5 0.1 0.0 38.2 0.1 0.6 0.4 53.7 17.2 23.1 2.8 0.4 0.0 0.3 33.4 0.1 1.5 0.0 0.0 0.0 0.9 0.2 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.0 1.6 0.0 0.0 0.2 25.4 27.2 20.5 33.3 22.1 23.2 22.1 24.6 22.8 19.4 27.7 21.6 50.8 0.0 1.1 81.9 0.5 24.0 0.5 0.0 2.2 6.6 1.4 3.3 17.3 1.5 0.0 1.8 4.2 0.6 6.0 0.3 0.0 0.8 1.6 2.8 99.5 32.2 0.0 0.0 7.9 0.0 1.1 123.5 2.0 2.3 0.0 2.5 6.4 1.9 1.5 0.0 1.3 0.7 0.0 0.0 35.6 10.9 165.3 3.1 24.9 45.0 0.7 50.7 23.7 10.1 3.3 0.1 0.1 203.8 2.3 0.7 0.3 0.1 0.7 2.9 1288.5 6.6 288.3 1.9 1.6 0.8 15.3 0.8 4.8 4.0 0.4 1.1 PDK3 ENSG00000067992 "Pyruvate dehydrogenase kinase 3" Q15120 X 24465270-24550466 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Carbohydrate metabolism, Glucose metabolism" "Kinase, Transferase" "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 71.6;Excitatory neurons: 92.8;Inhibitory neurons: 78.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046583, HPA072492" Approved Supported Nucleoli,Mitochondria NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 6: T47d - Mammary gland" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Mitochondria Nucleoli "HPA046583: AB_2679707, HPA072492: AB_2686526" "unprognostic (5.41e-3)" "unprognostic (5.43e-3)" "unprognostic (5.35e-3)" "unprognostic (3.40e-1)" "unprognostic (4.05e-3)" "unprognostic (5.38e-2)" "prognostic unfavorable (2.76e-4)" "unprognostic (1.51e-1)" "unprognostic (5.57e-2)" "unprognostic (1.35e-1)" "unprognostic (1.39e-2)" "unprognostic (2.02e-1)" "unprognostic (1.72e-1)" "unprognostic (1.02e-1)" "unprognostic (2.92e-1)" "unprognostic (2.28e-2)" "unprognostic (9.43e-3)" 4.4 2.0 4.4 5.6 6.2 8.9 8.8 1.4 7.5 3.5 2.5 6.1 8.2 2.8 10.9 3.9 5.9 3.2 7.4 13.2 4.7 8.8 4.7 5.0 7.9 2.6 4.2 4.8 2.9 6.7 5.8 4.1 2.4 4.6 5.3 6.0 11.1 2.9 1.4 6.8 8.3 4.5 0.9 7.7 6.9 11.6 9.1 6.3 2.3 1.8 8.0 4.2 4.1 4.2 11.5 5.2 4.2 8.0 0.2 0.0 5.0 3.4 2.4 4.1 6.9 0.5 13.9 10.4 2.3 0.8 11.6 2.1 12.3 8.4 10.4 9.7 6.0 5.3 6.1 3.3 1.4 4.6 5.8 0.9 3.6 1.1 1.2 0.5 6.8 10.9 0.9 16.5 0.5 20.9 9.4 6.0 8.1 12.2 5.6 5.0 8.0 17.3 4.1 21.4 2.6 4.0 17.9 8.0 5.5 7.3 9.6 1.9 0.1 3.3 3.6 5.8 4.2 11.0 8.9 12.9 8.7 7.7 6.4 13.3 15.4 37.9 11.8 19.6 16.5 7.5 9.1 10.3 12.2 7.3 7.6 8.6 57.6 13.3 18.8 3.5 8.3 12.4 4.4 6.2 1.4 7.5 13.2 4.7 2.6 4.2 2.4 0.9 9.1 4.2 3.9 3.2 2.0 19.6 15.2 4.6 9.5 13.5 30.1 3.5 11.1 8.1 6.6 1.5 5.2 1.8 0.0 5.5 16.6 4.2 3.9 4.3 71.6 2.1 2.9 3.8 4.2 14.3 92.8 5.1 32.1 4.9 5.6 2.8 5.7 4.9 5.3 5.3 15.0 8.4 78.0 2.9 10.2 19.8 7.4 35.9 3.7 17.4 16.0 35.6 10.3 3.7 25.7 19.6 14.0 2.1 0.3 5.7 19.0 5.9 13.3 14.2 2.4 3.5 0.0 2.0 10.6 10.2 8.3 6.8 4.4 17.8 18.2 9.7 4.1 8.4 PDSS1 "COQ1, COQ1A, TPRT, TPT" ENSG00000148459 "Decaprenyl diphosphate synthase subunit 1" Q5T2R2 10 26697701-26746798 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Isoprene biosynthesis, Ubiquinone biosynthesis" Transferase "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 19.1;lymphoid tissue: 13.8" "Cell type enhanced" "Detected in many" "Inhibitory neurons: 32.5;Proximal enterocytes: 29.8;Undifferentiated cells: 29.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in some" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038032, HPA042741" Uncertain Approved Cytosol NA NA "Cluster 24: B-cells - Unknown function" "Cluster 9: Intestine - Unknown function" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "HPA038032: AB_10670650, HPA042741: AB_2678139" "unprognostic (1.41e-2)" "unprognostic (3.92e-1)" "unprognostic (8.92e-3)" "prognostic unfavorable (1.66e-4)" "unprognostic (6.79e-3)" "unprognostic (5.43e-2)" "prognostic unfavorable (1.25e-5)" "unprognostic (2.47e-2)" "unprognostic (9.43e-2)" "unprognostic (2.33e-2)" "unprognostic (2.20e-1)" "unprognostic (4.11e-2)" "unprognostic (2.99e-3)" "unprognostic (2.93e-3)" "unprognostic (8.85e-2)" "unprognostic (9.83e-2)" "unprognostic (6.36e-2)" 2.1 1.4 0.8 5.3 0.9 5.8 2.3 2.6 1.4 1.8 0.6 14.1 19.1 1.9 1.3 4.3 1.5 1.6 2.8 0.8 0.8 6.2 3.6 2.2 4.0 0.8 0.9 1.7 1.3 2.2 0.8 2.4 0.9 1.5 15.1 1.9 1.8 1.3 5.7 1.4 15.3 2.9 0.8 1.8 2.8 2.8 0.9 13.8 1.2 9.5 4.7 3.1 2.2 1.1 15.6 11.8 8.9 16.3 2.9 5.4 12.2 14.0 3.6 20.0 13.7 18.3 8.4 35.0 7.2 7.0 7.6 19.2 28.6 21.8 16.7 14.7 23.6 30.4 9.9 13.6 4.3 20.3 11.6 6.8 9.2 19.0 5.0 3.5 10.7 22.8 28.4 9.3 14.4 24.9 64.6 14.7 17.9 24.9 11.3 29.6 25.1 25.5 12.0 7.3 25.7 15.8 13.5 27.6 15.9 9.2 9.9 23.7 6.8 11.1 17.9 22.9 22.5 3.6 14.1 25.6 10.9 51.3 8.7 0.0 2.8 0.5 0.4 2.3 1.0 0.2 0.8 0.6 2.6 2.4 1.6 0.7 0.1 0.4 1.2 0.7 0.0 0.7 0.8 0.9 2.6 1.4 0.8 0.8 0.8 0.9 0.9 0.8 0.9 1.1 3.6 0.0 0.0 18.9 4.8 6.9 3.6 5.7 8.0 2.9 4.4 5.1 2.2 5.7 3.9 3.7 4.2 7.7 4.9 11.7 7.9 6.1 12.0 2.1 3.8 2.7 10.8 8.4 16.9 3.9 12.4 3.4 10.2 3.3 0.0 3.7 1.8 4.5 8.8 1.7 32.5 13.0 6.1 5.3 2.7 4.1 2.1 7.7 1.8 5.6 6.2 1.2 1.0 6.6 6.5 5.6 9.8 2.6 9.1 3.7 29.8 26.3 2.1 4.9 0.0 4.1 6.5 12.5 9.4 13.6 3.1 6.3 4.8 4.6 29.8 3.3 PDSS2 "bA59I9.3, C6orf210, COQ1B" ENSG00000164494 "Decaprenyl diphosphate synthase subunit 2" Q86YH6 6 107152562-107459564 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Isoprene biosynthesis, Ubiquinone biosynthesis" Transferase "Cancer-related genes, Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Microglial cells: 82.4;Oligodendrocyte precursor cells: 72.9;Oligodendrocytes: 74.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029685, HPA029686" Approved Supported Cytosol NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 1: Thyroid gland - Transcription" "Cluster 32: U-937 - Innate immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "HPA029685: AB_10600219, HPA029686: AB_10602309" "prognostic unfavorable (1.34e-5)" "unprognostic (1.44e-1)" "prognostic favorable (5.74e-5)" "unprognostic (5.76e-2)" "unprognostic (1.42e-1)" "unprognostic (3.30e-2)" "unprognostic (3.26e-2)" "unprognostic (1.42e-1)" "unprognostic (1.15e-1)" "unprognostic (1.18e-1)" "unprognostic (9.38e-2)" "unprognostic (2.19e-1)" "prognostic favorable (3.75e-7)" "unprognostic (2.25e-1)" "unprognostic (2.86e-1)" "unprognostic (1.29e-1)" "unprognostic (2.11e-2)" 7.9 17.9 4.6 6.3 5.2 9.0 8.1 6.1 5.7 9.2 6.8 12.4 9.3 6.8 6.5 8.6 8.6 8.7 13.9 4.6 5.2 21.6 27.1 8.0 7.6 4.9 4.7 9.1 8.4 13.2 8.5 6.8 5.0 14.6 13.2 6.0 15.3 7.4 12.5 6.3 9.6 8.5 4.7 6.7 9.6 7.7 5.3 8.1 13.3 13.7 7.1 7.6 6.1 6.1 7.6 10.0 8.3 13.2 14.2 18.0 19.2 13.1 16.5 12.4 11.8 10.0 10.8 14.4 11.7 14.7 13.1 10.2 20.3 16.5 16.7 9.1 9.8 14.4 11.4 16.9 15.0 18.5 11.1 13.5 19.1 19.5 15.3 10.8 13.1 16.5 20.7 19.0 12.2 9.3 5.4 19.7 5.3 17.3 12.7 9.7 7.4 11.7 15.2 10.2 8.2 7.1 9.0 15.4 19.7 9.0 12.7 22.3 8.3 8.8 5.2 12.4 11.4 5.3 6.8 11.3 16.3 27.4 16.3 3.2 5.1 2.8 3.7 5.9 5.9 4.7 3.8 4.7 7.0 5.5 5.0 4.8 0.6 3.6 9.9 3.3 5.5 3.4 4.6 5.2 6.1 5.7 4.6 5.2 4.9 4.7 5.0 4.7 5.3 6.1 11.4 16.0 19.1 64.9 12.3 4.2 13.8 11.7 13.6 8.2 9.7 8.3 17.4 12.8 13.9 14.7 2.1 26.9 8.3 15.1 35.2 12.7 37.3 16.3 9.3 8.4 10.3 8.0 53.5 14.5 17.3 9.5 8.2 10.9 14.0 11.9 7.5 32.6 11.8 6.7 67.3 15.3 14.2 9.8 5.1 12.7 5.3 10.2 7.2 82.4 8.5 11.8 6.2 72.9 74.5 13.7 14.4 9.4 13.0 12.2 14.2 40.8 21.0 11.5 26.3 8.7 7.9 21.7 11.5 14.3 5.8 11.9 9.8 13.4 17.0 12.5 PDYN "ADCA, PENKB, SCA23" ENSG00000101327 Prodynorphin P01213 20 1978757-1994285 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins, Transporters" "Endorphin, Neuropeptide, Neurotransmitter, Opioid peptide" "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "brain: 47.0" "Group enriched" "Detected in some" 83 "Early spermatids: 47.8;Late spermatids: 119.0" "Group enriched" "Detected in some" 29 "glioma: 2.6;ovarian cancer: 1.6" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "THP-1: 1.0" "Group enriched" "Detected in many" 4 "basal ganglia: 152.2;hypothalamus: 60.7" "Region enhanced" "Detected in many" "basal ganglia: 132.2" "HPA053342, CAB079777" Enhanced Supported "Secreted in brain" NA NA "Cluster 65: Brain - Ion transport" "Cluster 43: THP-1 - Innate immune response" "Cluster 31: Spermatids - Spermatogenesis" "CAB079777: , HPA053342: AB_2682121" "unprognostic (7.00e-2)" "unprognostic (1.07e-1)" "unprognostic (1.40e-1)" "unprognostic (3.73e-2)" 0.0 0.0 43.2 0.1 31.1 0.0 0.0 0.0 43.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 47.0 17.6 0.0 0.0 0.0 0.0 1.8 4.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 21.0 0.0 0.0 8.3 9.2 0.2 0.1 0.0 0.0 0.0 0.0 4.5 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 43.2 31.1 0.0 43.1 47.0 17.6 1.8 4.1 0.2 21.0 9.2 4.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 47.8 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 119.0 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PDZD7 "bA108L7.8, DFNB57, FLJ23209, PDZK7" ENSG00000186862 "PDZ domain containing 7" Q9H5P4 10 101007679-101032295 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Deafness, Disease variant, Non-syndromic deafness, Retinitis pigmentosa, Usher syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "brain: 21.5;intestine: 20.0;pituitary gland: 6.0" "Cell type enhanced" "Detected in many" "Bipolar cells: 15.9;Cone photoreceptor cells: 22.9;Excitatory neurons: 32.3;Inhibitory neurons: 16.5;Proximal enterocytes: 56.7" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "A-431: 7.5;SCLC-21H: 11.7;THP-1: 18.2" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA074542 Supported Nucleoplasm NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 43: THP-1 - Innate immune response" "Cluster 45: Enterocytes - Digestion" Nucleoplasm "HPA074542: " "unprognostic (1.46e-1)" "unprognostic (2.85e-3)" "unprognostic (3.96e-2)" "unprognostic (2.10e-1)" "unprognostic (2.15e-2)" "unprognostic (2.83e-2)" "unprognostic (1.38e-2)" "unprognostic (5.31e-2)" "unprognostic (2.52e-2)" "unprognostic (2.95e-2)" "unprognostic (2.45e-1)" "unprognostic (1.87e-3)" "unprognostic (3.54e-3)" "unprognostic (3.89e-1)" "unprognostic (1.79e-1)" "unprognostic (3.51e-2)" "unprognostic (2.80e-1)" 1.5 1.3 5.8 1.0 8.0 1.3 0.5 10.2 15.4 0.7 0.7 0.4 12.8 1.4 0.9 0.3 0.4 1.9 0.6 5.7 4.5 1.5 0.1 1.0 0.9 21.5 7.7 0.6 0.9 1.1 6.0 1.0 21.0 0.7 0.2 2.3 1.1 0.5 0.9 2.4 20.0 1.0 2.7 1.6 1.0 1.2 8.8 0.7 1.2 0.2 0.1 0.4 0.8 9.9 7.5 0.9 0.5 0.7 0.9 0.1 2.3 1.2 0.6 0.0 0.3 1.5 1.7 3.7 3.5 0.3 1.0 2.2 0.2 0.7 0.0 1.0 2.5 0.2 3.8 2.3 0.6 0.5 3.1 0.3 0.1 0.2 0.1 4.2 0.2 3.3 0.6 0.7 0.1 1.8 0.5 1.2 0.6 1.5 2.4 1.6 1.0 0.4 1.8 0.6 11.7 5.4 0.8 0.3 1.2 1.0 2.4 18.2 0.5 1.1 2.4 1.4 1.0 1.5 0.1 0.2 6.4 1.2 0.6 0.6 0.4 0.5 0.3 0.4 0.3 0.3 0.2 0.4 0.1 0.3 0.4 0.2 1.6 0.8 0.3 0.1 0.1 0.3 5.8 8.0 10.2 15.4 5.7 4.5 21.5 7.7 21.0 2.7 8.8 9.9 0.8 0.0 0.0 1.3 0.1 0.5 0.5 0.2 0.0 15.9 0.5 0.9 1.4 2.8 0.2 1.8 22.9 0.2 0.1 0.2 1.9 0.7 1.7 2.1 0.3 0.7 0.0 0.0 32.3 0.4 5.2 0.8 1.1 0.3 0.0 1.6 0.7 0.0 2.1 1.7 16.5 1.5 0.0 1.3 2.7 2.6 0.3 1.0 0.0 5.6 0.3 0.9 1.0 0.5 6.9 1.3 1.2 1.2 0.3 0.4 56.7 1.6 1.3 8.3 0.0 1.4 1.7 2.9 3.7 0.2 0.4 1.9 0.8 0.1 1.0 0.2 PER2 KIAA0347 ENSG00000132326 "Period circadian regulator 2" O15055 2 238244044-238290102 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Biological rhythms, Transcription, Transcription regulation" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Skeletal myocytes: 110.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA053136, HPA060510" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 50: Non-specific - Ribosome" "Cluster 3: HMC-1 - Innate immune response" "Cluster 50: Fibroblasts - ECM organization" Nucleoplasm Cytosol "HPA053136: , HPA060510: AB_2684298" "unprognostic (1.96e-2)" "unprognostic (4.41e-2)" "unprognostic (1.88e-2)" "unprognostic (9.28e-2)" "unprognostic (2.52e-1)" "prognostic favorable (2.29e-4)" "unprognostic (2.47e-2)" "unprognostic (2.17e-2)" "unprognostic (3.59e-3)" "unprognostic (3.59e-2)" "unprognostic (1.76e-2)" "unprognostic (2.13e-1)" "unprognostic (6.81e-2)" "unprognostic (1.37e-1)" "unprognostic (2.27e-1)" "unprognostic (2.58e-1)" "unprognostic (5.22e-2)" 12.2 3.3 4.7 5.0 5.2 8.4 14.2 7.2 5.8 11.9 2.4 7.6 5.1 10.2 5.7 13.6 7.9 12.3 5.7 5.7 5.1 3.9 12.4 7.1 4.7 5.2 5.7 7.8 14.4 4.2 9.0 2.9 4.4 9.3 6.2 5.1 14.1 8.9 11.4 17.0 8.0 4.9 5.4 4.8 13.4 11.8 4.7 4.1 8.8 7.6 6.2 8.7 8.2 4.7 1.6 11.7 2.4 4.2 0.1 1.2 8.2 1.1 4.1 1.5 1.4 1.8 5.8 10.3 1.2 2.7 1.5 8.6 2.4 3.5 2.2 2.9 1.7 9.1 6.2 8.2 2.0 13.8 9.2 1.6 8.3 1.8 6.1 1.5 0.8 4.2 4.5 6.3 1.3 7.7 6.9 15.2 3.5 7.6 2.3 16.5 5.5 3.3 1.5 3.3 9.7 1.2 2.9 6.3 1.8 0.7 5.9 8.5 2.1 3.6 4.2 2.8 4.1 7.1 1.8 12.3 6.7 5.9 4.5 2.1 1.2 0.3 1.0 2.2 1.6 1.5 1.6 1.2 1.4 1.5 1.5 1.6 1.0 1.2 2.1 1.8 1.2 0.3 4.7 5.2 7.2 5.8 5.7 5.1 5.2 5.7 4.4 5.4 4.7 4.7 24.9 16.0 30.1 18.6 9.9 73.9 61.7 21.3 38.1 20.6 67.8 33.8 5.7 31.5 46.9 27.6 2.1 9.2 27.0 22.5 7.9 7.5 9.6 69.7 30.1 15.6 24.6 6.9 20.9 10.4 6.3 39.8 52.5 86.1 9.5 3.3 11.4 35.8 3.9 11.8 13.9 35.1 18.3 10.1 25.3 4.7 11.1 12.4 24.9 5.6 5.3 13.5 2.1 9.0 7.2 7.6 35.3 18.4 10.9 15.0 10.9 5.5 44.2 7.8 6.6 110.1 32.2 31.3 17.0 38.4 85.4 13.0 13.6 3.7 36.9 33.9 PER3 ENSG00000049246 "Period circadian regulator 3" P56645 1 7784320-7845177 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Biological rhythms, Transcription, Transcription regulation" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 137.8;Bipolar cells: 241.0;Horizontal cells: 124.5;Rod photoreceptor cells: 138.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "U-937: 36.0" "Low region specificity" "Detected in all" HPA019530 Approved Supported Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 54: Non-specific - Microtubule organization" "Cluster 17: WM-115 - Nervous system development" "Cluster 56: Bipolar cells - Visual perception" Cytosol "HPA019530: AB_1855201" "unprognostic (5.11e-2)" "prognostic favorable (7.14e-4)" "unprognostic (2.45e-2)" "unprognostic (2.97e-3)" "unprognostic (1.74e-1)" "prognostic favorable (1.34e-4)" "unprognostic (3.87e-1)" "unprognostic (5.53e-2)" "unprognostic (1.43e-1)" "unprognostic (1.77e-1)" "unprognostic (4.11e-2)" "unprognostic (8.96e-2)" "prognostic favorable (2.20e-5)" "unprognostic (1.16e-1)" "unprognostic (1.20e-1)" "unprognostic (3.46e-1)" "unprognostic (1.62e-1)" 13.9 11.1 10.1 4.6 14.1 0.7 12.6 46.1 15.9 12.4 3.1 18.4 6.4 19.0 10.6 17.0 12.6 12.2 22.3 9.6 9.9 12.5 25.6 12.0 4.7 12.7 13.9 18.5 17.0 19.8 16.9 2.7 14.4 15.6 6.6 55.9 25.4 20.5 28.7 13.4 9.4 10.7 11.8 9.0 17.4 8.8 14.4 4.6 23.3 24.3 7.2 10.3 10.4 26.0 7.2 2.1 6.1 1.8 1.1 0.6 1.8 3.0 5.5 5.5 7.6 8.6 27.7 3.2 1.6 12.4 9.4 3.3 22.1 1.4 8.3 0.2 1.2 22.7 8.3 1.3 6.8 0.7 7.6 3.0 2.4 6.0 6.1 11.4 2.0 1.6 18.7 5.8 2.4 5.7 12.7 10.2 3.3 16.0 5.9 11.0 2.2 0.2 3.1 1.3 7.9 8.5 26.3 0.1 11.0 6.1 6.6 1.0 4.2 14.9 21.4 4.6 4.0 0.8 0.5 2.7 10.5 36.0 21.2 0.3 0.6 0.4 1.5 0.7 1.8 0.6 0.7 1.4 0.7 0.2 0.6 0.7 0.0 0.3 1.3 0.5 1.3 0.6 10.1 14.1 46.1 15.9 9.6 9.9 12.7 13.9 14.4 11.8 14.4 26.0 45.0 19.2 12.1 137.8 3.9 30.1 13.1 4.3 40.5 241.0 14.3 17.3 17.0 8.6 9.9 9.2 81.3 1.7 3.0 5.0 9.8 3.2 16.5 4.4 19.6 17.5 6.6 0.0 42.8 4.8 0.5 33.6 20.4 4.3 26.0 6.9 10.8 28.1 9.4 124.5 64.1 4.0 12.2 8.5 14.8 5.8 12.5 11.2 12.4 40.3 3.4 91.2 2.1 62.4 91.6 5.7 1.6 27.4 3.3 9.7 5.0 5.2 9.7 138.5 6.6 39.2 25.4 22.2 23.2 32.9 25.6 0.5 5.9 11.5 1.7 8.6 PEX7 "PTS2R, RD" ENSG00000112357 "Peroxisomal biogenesis factor 7" O00628 6 136822564-136913934 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters" "Protein transport, Transport" "Cataract, Deafness, Disease variant, Ichthyosis, Peroxisome biogenesis disorder, Retinitis pigmentosa, Rhizomelic chondrodysplasia punctata" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal tubular cells: 60.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049202 Uncertain Supported Nucleoplasm,Vesicles NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Vesicles" "HPA049202: AB_2680674" "unprognostic (1.36e-2)" "unprognostic (2.07e-2)" "prognostic favorable (1.61e-4)" "unprognostic (4.01e-3)" "unprognostic (2.50e-2)" "unprognostic (6.38e-2)" "unprognostic (1.46e-1)" "unprognostic (1.71e-2)" "unprognostic (4.87e-2)" "unprognostic (1.23e-1)" "unprognostic (2.49e-1)" "unprognostic (6.88e-2)" "prognostic favorable (1.85e-10)" "unprognostic (3.57e-1)" "unprognostic (1.44e-1)" "unprognostic (2.52e-2)" "unprognostic (2.65e-1)" 5.2 14.8 4.6 2.0 4.8 3.8 11.9 6.0 5.2 6.8 5.1 7.9 5.3 4.2 17.2 7.3 8.7 4.5 11.7 4.2 4.2 15.6 9.1 4.9 3.2 4.3 4.4 5.0 26.9 17.1 6.0 4.1 4.5 10.4 8.4 6.9 10.6 6.4 10.7 11.2 4.7 3.3 4.4 3.3 15.6 10.0 4.7 3.7 11.0 9.8 3.3 5.4 6.7 5.5 4.4 4.3 4.4 6.2 6.6 9.8 2.4 6.1 8.9 7.5 7.4 4.9 6.0 1.5 11.3 8.3 8.5 5.3 3.3 13.8 9.8 5.7 7.5 6.4 4.3 0.9 13.9 8.1 5.3 9.6 13.1 5.4 7.9 8.7 5.4 12.0 13.0 5.2 10.6 13.4 3.5 7.9 5.0 13.9 8.3 4.8 3.4 5.7 17.4 6.4 8.3 10.6 6.5 9.0 8.4 4.9 5.8 7.7 2.5 4.8 1.7 7.3 5.3 6.9 5.1 0.0 4.2 6.4 4.9 2.9 1.3 2.2 0.7 1.0 0.7 1.5 1.3 1.6 2.3 1.0 2.4 1.5 0.9 1.6 1.9 1.8 2.3 0.9 4.6 4.8 6.0 5.2 4.2 4.2 4.3 4.4 4.5 4.4 4.7 5.5 4.9 3.2 9.4 10.7 6.3 12.1 14.9 16.5 9.1 9.1 19.5 13.8 18.7 11.5 14.7 11.0 8.4 19.6 2.3 11.6 60.7 16.5 12.5 18.7 6.4 5.6 10.3 15.8 12.4 22.7 21.0 6.8 10.2 11.1 14.0 7.9 6.1 7.0 12.4 0.0 14.7 21.8 30.5 5.7 6.2 10.2 9.0 6.4 14.2 5.6 11.9 20.8 4.1 17.6 19.9 16.7 13.2 9.8 3.7 16.0 15.0 38.3 16.1 9.9 6.6 5.7 8.2 30.6 16.7 15.4 18.2 17.1 6.6 24.3 17.2 17.4 PFN1 ENSG00000108518 "Profilin 1" P07737 17 4945652-4949061 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" Actin-binding "Amyotrophic lateral sclerosis, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 5241.0;monocytes: 4824.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB037134, CAB037140" Enhanced Approved Cytosol NA NA 660000000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 3: Monocytes - Immune response regulation" Cytosol "CAB037134: AB_1079599, CAB037140: AB_1079598" "unprognostic (1.07e-1)" "unprognostic (3.57e-1)" "unprognostic (1.60e-1)" "unprognostic (5.45e-3)" "unprognostic (1.65e-1)" "unprognostic (7.54e-2)" "unprognostic (4.01e-3)" "unprognostic (7.83e-3)" "unprognostic (3.38e-1)" "unprognostic (1.09e-3)" "unprognostic (2.17e-1)" "unprognostic (3.40e-2)" "prognostic unfavorable (1.06e-4)" "unprognostic (3.62e-1)" "unprognostic (8.17e-2)" "unprognostic (1.02e-2)" "unprognostic (1.28e-1)" 573.1 365.8 278.0 1133.4 302.0 1613.0 397.0 323.2 333.0 393.7 289.2 970.2 764.0 734.4 346.4 582.7 500.9 372.7 343.8 281.8 301.5 460.9 661.6 559.2 1357.9 347.3 325.4 247.7 246.4 311.3 198.9 581.1 348.6 419.4 808.4 71.8 346.9 601.4 337.9 449.8 772.9 1034.7 315.2 910.8 675.1 116.2 366.2 1197.6 269.2 238.7 1440.0 842.6 425.0 355.2 3019.5 4276.8 1461.5 1205.2 778.8 977.1 1972.7 2416.8 1970.4 2568.6 1923.7 1684.1 1181.1 2476.9 1892.0 2542.0 1453.6 1825.4 1383.6 3040.5 2049.6 3560.1 2355.1 2516.6 2034.3 2225.8 2144.0 1630.4 5006.0 1152.4 1331.9 1957.6 1939.8 1477.6 2361.3 1646.4 1488.6 1736.7 3150.5 1815.0 2469.9 3448.0 2095.2 1474.7 2297.3 2451.9 2035.1 1494.6 2491.7 1909.8 564.0 1586.2 1910.5 1180.9 1679.7 1226.8 1121.0 1359.7 2731.7 2136.6 1675.1 1512.3 3969.3 931.3 1070.7 1799.3 1834.4 1949.7 3316.4 8100.1 8206.3 13914.4 9850.0 10858.8 6780.3 5722.0 8185.7 9586.6 9920.0 4970.0 5238.0 7604.7 9387.0 9112.1 13547.4 7809.7 11245.6 23570.1 278.0 302.0 323.2 333.0 281.8 301.5 347.3 325.4 348.6 315.2 366.2 355.2 561.8 112.2 176.1 12.1 1070.6 1806.0 873.2 3658.3 1003.3 25.0 767.4 914.1 147.6 457.5 1020.0 741.2 0.0 1911.0 1725.6 1733.8 992.0 1866.6 19.7 313.4 546.1 806.6 603.7 713.5 7.1 1625.2 5241.0 599.9 733.4 422.7 486.5 291.2 637.5 754.3 4094.2 38.7 6.4 1399.7 1452.6 1434.3 2934.8 31.0 263.8 1854.7 873.4 21.5 4824.7 99.8 3216.3 9.0 37.2 2933.5 1585.7 375.0 927.8 1238.2 1472.2 1671.2 559.4 17.8 506.2 282.3 1838.4 97.4 355.4 1170.1 1513.5 1682.8 1804.7 410.7 1355.5 1177.9 PHACTR1 "dJ257A7.2, KIAA1733, RPEL1" ENSG00000112137 "Phosphatase and actin regulator 1" Q9C0D0 6 12716554-13287843 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Actin-binding, Protein phosphatase inhibitor" Epilepsy "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 38.0;brain: 52.1" "Group enriched" "Detected in many" 4 "Excitatory neurons: 1954.8;Inhibitory neurons: 523.7" "Cancer enriched" "Detected in many" 5 "melanoma: 10.2" "Group enriched" "Detected in many" 6 "basal ganglia: 52.1;cerebral cortex: 27.3;hippocampal formation: 14.8" "Immune cell enhanced" "Detected in many" "plasmacytoid DC: 37.8" "Group enriched" "Detected in many" 18 "B-cells: 13.6;dendritic cells: 37.8;granulocytes: 18.7" "Cell line enhanced" "Detected in many" "HMC-1: 74.6;SK-MEL-30: 79.5;U-266/70: 176.1;U-266/84: 133.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029755, HPA029756, HPA029757" Enhanced Uncertain "Plasma membrane" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 29: U-266 - Adaptive immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" "HPA029755: AB_10600089, HPA029756: AB_10601852, HPA029757: AB_10669870" "unprognostic (7.86e-2)" "unprognostic (7.49e-2)" "unprognostic (2.74e-2)" "unprognostic (2.80e-1)" "unprognostic (1.59e-1)" "unprognostic (1.29e-1)" "unprognostic (7.72e-2)" "unprognostic (4.80e-2)" "unprognostic (1.10e-1)" "unprognostic (1.22e-1)" "unprognostic (3.67e-4)" "unprognostic (1.53e-1)" "prognostic unfavorable (5.48e-6)" "unprognostic (1.31e-1)" "unprognostic (1.43e-1)" "unprognostic (5.00e-2)" "unprognostic (1.16e-1)" 5.1 2.0 4.3 12.6 52.1 38.0 1.5 0.0 27.3 1.1 0.0 2.0 2.8 1.1 2.5 1.7 2.4 6.0 18.1 14.8 0.0 7.5 2.6 13.9 14.9 0.0 0.0 1.6 6.0 0.4 4.0 2.6 0.0 1.1 2.0 7.8 1.0 0.7 0.4 3.3 3.0 2.5 0.0 11.2 3.7 1.9 0.0 3.5 1.1 0.7 23.9 4.1 1.0 5.4 0.2 0.3 4.5 0.3 0.0 0.1 14.7 1.5 5.0 4.1 7.7 0.3 0.3 0.9 1.2 0.6 6.4 0.3 0.0 0.2 5.3 17.3 0.6 39.5 0.6 0.2 0.5 38.1 74.6 1.7 0.1 0.0 0.7 0.3 6.2 2.1 18.6 31.1 4.1 0.0 0.4 22.4 5.1 0.0 0.0 17.7 10.2 2.9 2.9 0.5 18.3 5.8 0.1 9.9 79.5 6.1 21.2 8.6 6.8 0.6 1.1 0.0 0.4 176.1 133.7 33.5 2.3 9.8 26.0 0.2 1.3 1.5 0.1 1.1 0.1 9.9 0.1 0.0 6.7 13.6 0.0 0.1 18.7 0.1 0.9 37.8 0.0 0.9 4.3 52.1 0.0 27.3 14.8 0.0 0.0 0.0 0.0 0.0 0.0 5.4 12.6 67.3 48.5 265.1 131.6 3.7 1.4 0.8 1.2 43.5 2.1 3.9 10.4 4.3 8.3 62.5 4.2 1.4 79.4 0.7 31.3 0.7 59.9 5.5 2.8 12.9 1.8 13.7 1954.8 2.9 2.3 8.6 0.5 15.0 81.2 2.7 13.6 1.1 83.1 180.0 523.7 0.2 0.0 138.2 91.5 79.8 4.7 188.5 48.0 114.3 20.5 28.4 6.2 186.5 247.8 0.8 0.2 6.4 59.6 1.0 0.3 1.0 5.1 14.0 0.0 4.0 4.3 2.0 4.8 2.1 3.1 1.9 8.6 6.6 1.0 0.8 PHOX2A "ARIX, CFEOM2, FEOM2, PMX2A" ENSG00000165462 "Paired like homeobox 2A" O14813 11 72239077-72245664 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 7 "adrenal gland: 19.9;brain: 18.3" "Cell type enriched" "Detected in single" 4 "Spermatogonia: 2.9" "Cancer enriched" "Detected in some" 9 "ovarian cancer: 9.3" "Region enriched" "Detected in some" 9 "pons: 18.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 226 "SH-SY5Y: 569.5" "Not detected" "Not detected" "Low region specificity" "Detected in single" "HPA053810, HPA065621, HPA078004" Enhanced Supported Nucleoplasm No NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" Nucleoplasm "HPA053810: , HPA065621: AB_2685522, HPA078004: AB_2732367" "unprognostic (5.84e-2)" "unprognostic (8.51e-2)" "unprognostic (5.07e-2)" "unprognostic (2.19e-1)" "unprognostic (2.13e-1)" "unprognostic (9.92e-4)" "unprognostic (3.03e-2)" 0.3 19.9 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 2.6 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 1.9 0.0 0.2 0.0 0.5 0.0 18.3 0.1 0.5 0.0 0.0 0.0 0.0 0.0 1.0 0.2 0.3 0.0 1.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 569.5 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 1.9 18.3 0.3 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PHOX2B "NBPhox, PMX2B" ENSG00000109132 "Paired like homeobox 2B" Q99453 4 41744082-41748725 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Developmental protein, DNA-binding" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "adrenal gland: 8.6;brain: 15.2" "Cell type enriched" "Detected in single" 10 "Cardiomyocytes: 1.0" "Not detected" "Not detected" "Region enhanced" "Detected in some" "medulla oblongata: 10.1;pons: 15.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 89 "SH-SY5Y: 132.7" "Region enriched" "Detected in single" 17 "pons and medulla: 5.6" "Group enriched" "Detected in some" 18 "medulla oblongata: 1.4;pons: 2.0" "HPA074325, HPA074941" Enhanced Enhanced Nucleoplasm NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 43: Cardiomyocytes - Nuclear processes" Nucleoplasm "HPA074325: AB_2686678, HPA074941: AB_2732272" "unprognostic (1.01e-1)" "unprognostic (2.47e-1)" "unprognostic (5.27e-2)" 0.0 8.6 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.1 3.7 0.0 0.1 0.0 0.0 0.0 15.2 0.0 0.8 0.0 0.0 0.0 0.0 0.0 1.1 0.3 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 132.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.1 3.7 15.2 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PHYH "PAHX, PHYH1, RD" ENSG00000107537 "Phytanoyl-CoA 2-hydroxylase" O14832 10 13277796-13302412 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Dioxygenase, Oxidoreductase" "Cataract, Deafness, Disease variant, Ichthyosis, Peroxisome biogenesis disorder, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 667.8;skeletal muscle: 483.6;tongue: 412.7" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 258.6;Proximal tubular cells: 414.6" "Cancer enhanced" "Detected in all" "liver cancer: 78.1" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC diff: 110.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007598, HPA011796" Enhanced NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA007598: AB_1855334, HPA011796: AB_1855335" "unprognostic (5.78e-2)" "unprognostic (3.83e-1)" "unprognostic (6.98e-2)" "unprognostic (3.62e-2)" "unprognostic (5.52e-2)" "unprognostic (1.61e-3)" "unprognostic (1.16e-1)" "unprognostic (1.95e-2)" "unprognostic (7.09e-2)" "unprognostic (6.15e-2)" "unprognostic (1.59e-1)" "unprognostic (3.24e-1)" "prognostic favorable (7.28e-12)" "unprognostic (2.07e-1)" "unprognostic (1.06e-1)" "unprognostic (1.07e-2)" "unprognostic (2.19e-1)" 57.9 66.5 22.9 9.5 23.7 8.2 32.2 23.5 28.3 28.8 31.7 46.5 58.7 22.1 16.7 22.9 16.7 28.2 126.5 21.7 24.1 191.4 667.8 17.3 7.5 21.6 24.4 36.8 48.2 56.7 20.9 19.3 22.8 22.5 37.2 28.2 33.7 25.4 483.6 17.5 55.8 23.2 22.7 12.8 44.2 15.1 26.0 5.6 56.0 412.7 5.4 27.0 14.8 23.6 17.2 35.2 15.6 22.5 110.7 69.9 12.4 17.2 23.9 19.4 19.1 9.1 30.3 0.9 12.9 29.0 47.0 7.8 20.5 20.2 11.8 41.4 10.7 14.9 9.3 36.6 54.8 2.5 26.8 50.3 28.9 21.0 8.4 22.7 18.7 16.8 8.4 32.2 45.5 16.3 9.2 12.1 14.4 49.4 12.6 15.7 24.1 5.8 40.6 21.9 5.3 16.8 64.8 1.4 32.9 12.5 64.8 44.2 6.4 29.5 10.6 36.4 11.8 36.6 26.3 3.3 38.3 18.9 11.6 16.3 18.7 8.2 8.0 14.2 17.6 11.0 9.9 10.4 15.8 5.6 12.5 12.7 0.8 4.4 11.2 14.4 10.5 12.3 22.9 23.7 23.5 28.3 21.7 24.1 21.6 24.4 22.8 22.7 26.0 23.6 53.6 12.8 19.2 8.5 14.5 11.9 27.6 19.1 6.2 47.0 22.6 24.5 258.6 77.2 19.7 35.0 22.9 137.8 20.5 72.9 144.8 40.6 33.1 18.5 29.0 29.7 31.8 15.2 7.1 19.6 34.3 41.3 41.8 26.8 30.4 28.3 25.0 145.5 55.4 21.9 5.6 57.4 46.8 21.0 22.0 45.4 25.4 25.3 17.8 4.7 10.3 69.3 7.2 2.5 2.4 16.7 46.0 37.6 15.1 11.9 141.9 414.6 19.6 41.8 19.7 30.2 37.5 12.5 1.6 7.3 13.4 83.9 25.2 103.3 46.9 18.1 PIGB ENSG00000069943 "Phosphatidylinositol glycan anchor biosynthesis class B" Q92521 15 55318960-55355648 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "GPI-anchor biosynthesis" "Glycosyltransferase, Transferase" Epilepsy "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039929 Uncertain Uncertain "Plasma membrane,Cytosol" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 32: U-937 - Innate immune response" "Cluster 57: B-cells - Immune response" "Plasma membrane, Cytosol" "HPA039929: AB_10673539" "unprognostic (1.91e-2)" "unprognostic (7.45e-2)" "unprognostic (3.00e-1)" "unprognostic (2.03e-2)" "unprognostic (2.96e-2)" "unprognostic (4.65e-2)" "unprognostic (2.04e-1)" "unprognostic (3.37e-3)" "unprognostic (7.52e-2)" "unprognostic (3.52e-2)" "unprognostic (2.56e-2)" "unprognostic (4.27e-2)" "unprognostic (2.13e-1)" "unprognostic (1.30e-1)" "unprognostic (2.86e-1)" "unprognostic (5.93e-2)" "unprognostic (4.24e-2)" 6.4 4.8 2.3 5.8 2.6 9.1 9.0 2.8 2.6 5.5 3.1 7.0 7.5 6.4 11.0 5.7 7.8 6.3 2.8 2.5 3.3 10.3 9.4 6.3 8.2 2.8 2.7 4.7 5.7 10.6 3.9 4.8 2.6 7.7 7.8 7.9 4.3 6.8 1.5 6.1 5.8 5.6 2.7 6.1 7.6 6.5 2.7 6.3 13.3 1.8 8.6 7.5 3.7 3.1 10.5 12.2 5.8 4.1 6.6 13.2 7.8 9.0 19.9 10.4 17.8 5.1 10.3 10.9 10.4 12.9 15.6 18.3 3.3 9.5 8.6 10.4 6.4 10.9 13.6 6.7 11.9 30.8 8.7 12.5 11.4 7.9 10.7 13.8 13.6 9.2 12.2 6.9 15.0 9.1 3.4 12.8 3.1 7.9 4.8 4.9 5.6 24.1 18.4 12.4 2.5 6.2 8.1 12.2 17.3 5.4 11.7 22.2 9.5 13.6 4.3 3.7 18.6 8.1 15.9 8.6 12.4 34.5 10.2 13.6 7.7 3.3 6.2 9.7 7.0 6.0 6.1 6.9 7.0 3.9 4.8 5.5 14.5 5.3 11.4 5.4 6.5 5.5 2.3 2.6 2.8 2.6 2.5 3.3 2.8 2.7 2.6 2.7 2.7 3.1 3.5 9.6 9.5 17.6 27.5 4.6 9.5 14.9 4.6 3.3 5.6 4.2 3.4 1.5 14.9 0.0 12.5 12.4 11.2 4.8 1.9 7.4 26.8 4.3 3.2 4.7 6.6 8.2 18.3 10.9 12.0 6.0 6.1 6.4 8.2 4.6 6.8 4.4 8.6 1.7 17.7 4.1 4.1 7.5 6.7 5.1 1.5 8.8 3.6 12.2 8.4 2.7 11.3 17.1 14.6 6.9 4.0 1.5 3.8 3.4 6.4 9.7 7.9 9.4 6.6 4.8 4.2 5.9 3.8 5.7 4.0 6.6 12.5 4.2 4.0 7.4 PIGP "DCRC, DSCR5, DSRC" ENSG00000185808 "Phosphatidylinositol glycan anchor biosynthesis class P" P57054 21 37062846-37073170 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "GPI-anchor biosynthesis" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 350.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026921 Uncertain Approved Vesicles Yes No "Cluster 30: Non-specific - Translation" "Cluster 29: Non-specific - Vesicular transport" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Vesicles "HPA026921: AB_1847874" "unprognostic (4.47e-3)" "unprognostic (9.45e-2)" "unprognostic (3.03e-1)" "unprognostic (2.40e-1)" "unprognostic (2.85e-2)" "unprognostic (1.92e-2)" "unprognostic (1.92e-2)" "unprognostic (5.54e-2)" "unprognostic (1.55e-1)" "unprognostic (1.22e-2)" "unprognostic (4.21e-3)" "unprognostic (1.12e-2)" "unprognostic (1.96e-2)" "unprognostic (1.93e-1)" "unprognostic (5.48e-2)" "unprognostic (1.02e-1)" "unprognostic (6.55e-2)" 33.9 41.3 18.7 12.5 20.2 9.1 35.4 22.4 24.7 22.9 24.8 24.2 19.0 18.3 107.2 16.8 25.7 22.5 40.1 18.1 22.8 35.9 54.7 21.6 16.6 22.8 21.6 27.9 41.4 51.9 38.0 20.9 22.6 33.7 27.4 28.6 32.2 26.7 44.0 12.4 15.5 17.1 22.1 14.9 22.8 36.5 20.0 22.0 36.3 42.8 19.7 26.2 13.2 25.4 25.9 11.5 23.7 14.8 41.5 28.6 16.9 21.9 38.7 18.6 21.1 15.4 53.7 37.1 45.7 32.0 81.4 19.4 22.7 25.5 18.5 37.4 36.1 86.2 13.8 21.3 26.3 26.9 16.6 26.5 47.2 33.4 43.0 42.2 35.1 80.5 50.7 61.8 38.5 16.5 32.9 25.5 19.6 76.8 27.9 31.0 12.1 37.0 48.2 13.3 49.2 29.8 61.4 43.0 81.8 33.6 35.2 53.2 18.3 12.9 6.6 14.8 19.3 81.1 96.5 42.0 38.1 30.5 43.4 0.4 13.5 3.7 19.6 20.3 24.8 34.2 25.1 21.6 20.9 28.1 33.3 29.0 1.9 16.8 22.6 30.9 20.6 15.6 18.7 20.2 22.4 24.7 18.1 22.8 22.8 21.6 22.6 22.1 20.0 25.4 37.4 28.9 41.8 9.8 37.0 33.0 58.9 88.9 35.3 21.2 74.1 86.4 82.4 42.9 65.1 44.1 10.4 60.7 29.4 21.6 90.1 61.8 79.3 67.0 35.9 31.3 44.9 25.7 6.9 71.3 52.4 48.9 30.1 49.3 15.9 32.2 35.3 79.8 66.7 16.8 8.7 63.9 65.1 57.6 39.9 75.6 69.0 44.1 37.4 2.8 50.2 37.0 23.7 7.5 18.2 57.7 50.3 35.0 54.3 45.6 52.3 97.1 86.9 33.6 65.7 32.7 44.6 350.8 177.5 44.2 26.3 52.3 31.7 62.6 53.1 63.7 PIGQ "GPI1, hGPI1" ENSG00000007541 "Phosphatidylinositol glycan anchor biosynthesis class Q" Q9BRB3 16 566995-584109 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "GPI-anchor biosynthesis" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Erythroid cells: 78.9;Late spermatids: 61.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039105, HPA039828, HPA061414" Approved Approved "Nucleoplasm,Golgi apparatus,Vesicles" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 18: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 6: Erythroid cells - Oxygen transport" "Golgi apparatus, Vesicles" Nucleoplasm "HPA039105: AB_10796221, HPA039828: AB_10795158, HPA061414: AB_2684508" "unprognostic (1.23e-2)" "unprognostic (6.12e-3)" "unprognostic (2.81e-1)" "unprognostic (2.65e-2)" "unprognostic (1.09e-2)" "unprognostic (2.42e-1)" "unprognostic (9.58e-2)" "unprognostic (8.05e-2)" "unprognostic (2.12e-1)" "unprognostic (2.02e-1)" "unprognostic (3.02e-2)" "unprognostic (8.98e-2)" "prognostic favorable (2.53e-6)" "unprognostic (2.73e-1)" "unprognostic (2.60e-1)" "unprognostic (2.55e-1)" "unprognostic (2.80e-2)" 13.3 23.9 7.1 3.8 8.0 30.4 15.0 2.0 12.0 15.4 8.6 16.2 7.5 18.3 1.4 13.2 16.5 2.8 13.3 9.6 5.2 30.7 19.0 17.9 2.5 6.6 9.7 15.6 21.9 9.4 25.4 3.3 6.5 19.4 1.1 1.2 19.3 5.8 18.4 15.7 12.6 1.6 3.5 15.0 17.0 28.1 6.0 2.7 31.1 1.7 1.2 15.8 12.1 4.3 14.2 21.9 7.3 10.3 4.6 2.7 13.9 14.7 5.6 6.3 6.6 14.6 12.9 7.6 18.6 3.3 5.5 22.2 3.3 6.4 1.3 21.9 30.4 11.4 23.8 10.8 8.9 10.1 10.2 5.2 9.8 10.2 2.0 4.0 6.1 13.7 26.1 4.1 2.1 20.7 18.3 11.4 10.0 3.0 21.9 36.6 6.4 17.7 5.6 5.6 13.2 21.4 16.8 7.6 10.8 2.3 17.3 6.9 14.5 10.4 13.7 11.7 10.4 15.8 5.0 6.0 4.8 5.4 10.4 0.9 2.8 1.6 2.8 3.1 2.4 2.3 2.3 2.6 2.7 2.5 2.5 1.6 3.0 3.3 3.7 5.6 2.4 2.6 7.1 8.0 2.0 12.0 9.6 5.2 6.6 9.7 6.5 3.5 6.0 4.3 9.7 16.0 20.3 14.0 6.9 4.8 6.6 8.4 5.2 12.1 15.8 11.0 8.4 4.3 10.6 40.5 4.2 10.5 8.8 31.5 3.9 19.3 33.6 21.0 7.8 9.0 20.3 78.9 19.3 17.4 8.4 9.4 16.3 11.4 8.2 19.7 6.4 16.4 9.5 10.1 13.8 13.0 8.2 9.1 4.4 61.4 7.5 8.2 16.0 3.7 7.7 14.6 10.3 7.5 6.6 14.1 11.6 7.2 9.1 6.9 7.6 12.4 23.3 13.7 0.0 7.7 9.9 30.1 13.6 6.2 4.8 5.9 7.8 11.1 16.9 5.0 PIK3R5 "p101, P101-PI3K" ENSG00000141506 "Phosphoinositide-3-kinase regulatory subunit 5" Q8WYR1 17 8878911-8965712 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 87.4" "Cell type enhanced" "Detected in some" "dendritic cells: 29.9;Kupffer cells: 35.7;Langerhans cells: 40.5;Macrophages: 36.8;Microglial cells: 79.6;NK-cells: 32.0;Plasma cells: 24.7;T-cells: 25.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "HDLM-2: 39.2;HMC-1: 5.7;JURKAT: 13.7;U-937: 11.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA044505, HPA052247, HPA052412" Uncertain Supported "Centriolar satellite,Cytosol" No NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 44: HDLM-2 - Immune response" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "Centriolar satellite" "HPA044505: AB_2678964, HPA052247: AB_2681772, HPA052412: AB_2681823" "unprognostic (2.81e-1)" "unprognostic (1.31e-2)" "unprognostic (3.10e-2)" "unprognostic (2.37e-2)" "unprognostic (3.44e-2)" "unprognostic (9.89e-3)" "unprognostic (1.42e-1)" "unprognostic (5.70e-2)" "unprognostic (1.38e-1)" "unprognostic (7.95e-2)" "unprognostic (1.33e-2)" "unprognostic (2.66e-1)" "unprognostic (7.59e-3)" "unprognostic (6.89e-2)" "unprognostic (1.09e-1)" "unprognostic (1.94e-1)" "unprognostic (1.24e-1)" 6.5 3.6 1.4 19.7 1.3 87.4 2.7 1.3 7.5 2.1 1.6 3.3 3.3 1.4 0.8 2.5 3.0 6.6 1.8 1.3 1.7 1.4 2.9 14.1 13.7 4.0 2.7 0.8 1.3 0.8 0.8 3.1 3.6 1.5 2.6 0.0 2.1 1.0 0.7 1.5 9.5 3.9 2.8 22.4 3.6 2.2 6.8 12.3 1.7 0.9 8.9 6.5 1.4 5.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 39.2 0.4 1.5 0.0 0.0 0.0 0.5 5.7 0.0 0.0 0.0 0.0 0.0 0.0 13.7 0.0 0.0 0.0 0.3 1.5 2.5 0.6 0.0 0.0 4.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 5.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.2 0.0 9.5 16.1 5.7 18.1 14.3 11.8 4.3 10.1 15.6 11.5 5.7 7.5 12.0 34.4 8.6 19.0 9.0 13.2 16.2 1.4 1.3 1.3 7.5 1.3 1.7 4.0 2.7 3.6 2.8 6.8 5.4 0.2 0.0 6.1 0.7 11.7 1.0 0.0 0.0 0.0 0.0 0.2 0.3 2.1 1.5 0.0 0.0 0.0 0.1 29.9 0.0 0.0 0.1 4.5 0.1 0.1 0.7 0.0 4.0 0.3 0.0 0.3 0.5 1.5 0.1 5.1 0.0 1.4 0.4 18.3 0.0 0.5 0.0 0.0 35.7 40.5 12.2 0.3 36.8 1.8 79.6 19.8 0.0 32.0 1.0 0.3 0.0 0.0 0.0 24.7 0.1 0.0 0.2 0.0 0.0 0.0 0.4 1.4 0.6 0.4 0.1 0.9 0.4 25.7 0.0 0.0 0.0 PIKFYVE "FAB1, KIAA0981, MGC40423, p235, PIP5K, PIP5K3, ZFYVE29" ENSG00000115020 "Phosphoinositide kinase, FYVE-type zinc finger containing" Q9Y2I7 2 208266255-208358746 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase" "Corneal dystrophy, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "B-cells: 82.0;Oligodendrocyte precursor cells: 80.9;Oligodendrocytes: 81.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042604 Uncertain NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 34: Non-specific - Transcription" "Cluster 32: U-937 - Innate immune response" "Cluster 57: B-cells - Immune response" "HPA042604: AB_10796580" "unprognostic (1.00e-1)" "unprognostic (1.67e-1)" "unprognostic (1.88e-1)" "unprognostic (3.03e-1)" "unprognostic (2.04e-2)" "prognostic favorable (6.81e-4)" "unprognostic (6.82e-3)" "unprognostic (6.45e-2)" "unprognostic (1.85e-2)" "unprognostic (3.81e-2)" "unprognostic (1.77e-1)" "unprognostic (2.10e-2)" "unprognostic (1.32e-1)" "unprognostic (2.14e-1)" "unprognostic (3.29e-1)" "unprognostic (1.06e-1)" "unprognostic (7.05e-2)" 10.4 7.9 7.6 12.0 7.6 28.8 8.1 14.3 9.3 9.1 10.5 6.1 6.0 9.3 11.9 6.3 6.4 7.2 7.4 7.7 7.3 10.6 10.5 7.8 17.4 8.0 7.4 10.0 22.2 11.1 6.0 9.7 6.9 11.5 7.4 17.3 6.5 8.0 6.5 8.2 7.3 8.9 7.4 15.1 8.0 14.0 8.9 19.3 12.2 9.0 16.1 8.2 5.8 11.1 8.0 7.9 18.3 14.3 18.1 21.4 8.5 9.6 19.5 11.1 15.0 11.3 6.6 9.2 9.8 16.6 21.7 8.0 16.1 10.8 18.8 7.9 10.1 33.0 15.6 10.2 13.7 29.5 28.5 16.0 11.5 13.0 24.1 18.5 18.3 24.1 22.7 16.1 14.0 3.4 26.9 22.1 15.2 6.1 5.9 9.9 14.2 12.7 14.2 11.5 5.8 13.8 10.6 6.8 19.2 21.4 4.3 31.3 21.2 13.8 9.2 9.4 9.0 11.2 14.2 19.2 11.1 25.2 13.9 0.9 0.5 0.4 0.9 0.4 0.5 4.4 1.2 1.4 0.5 3.2 0.9 1.1 0.7 3.2 0.7 1.2 0.9 0.3 7.6 7.6 14.3 9.3 7.7 7.3 8.0 7.4 6.9 7.4 8.9 11.1 18.8 25.6 16.2 58.8 82.0 15.3 6.7 7.8 25.6 21.9 10.5 6.6 17.5 11.5 10.6 11.0 16.7 8.1 14.4 8.1 5.9 5.4 10.4 11.3 19.4 18.8 18.6 25.5 72.6 4.3 5.7 15.7 16.3 21.7 36.1 18.0 18.2 19.4 14.4 10.1 67.9 9.6 4.1 29.9 32.5 8.3 18.6 28.5 10.6 48.7 19.1 13.5 16.5 80.9 81.7 8.5 5.9 13.5 10.3 18.1 14.3 9.9 9.2 19.7 13.1 15.4 18.9 30.5 23.0 14.8 15.3 7.3 21.5 13.3 8.8 11.4 PINK1 "BRPK, PARK6" ENSG00000158828 "PTEN induced kinase 1" Q9BXM7 1 20633458-20651511 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Autophagy "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 384.4;tongue: 392.3" "Cell type enhanced" "Detected in many" "Late spermatids: 151.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 8.1" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001931, CAB026191" Enhanced NA NA "Cluster 10: Basophils - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB026191: , HPA001931: AB_1079620" "unprognostic (3.73e-3)" "unprognostic (2.29e-2)" "unprognostic (3.22e-1)" "unprognostic (4.33e-2)" "unprognostic (4.91e-2)" "unprognostic (2.93e-2)" "unprognostic (1.56e-2)" "unprognostic (3.36e-2)" "unprognostic (3.51e-2)" "unprognostic (4.06e-3)" "unprognostic (3.34e-2)" "unprognostic (2.54e-1)" "prognostic favorable (1.11e-16)" "unprognostic (2.68e-1)" "unprognostic (1.62e-1)" "unprognostic (6.57e-2)" "unprognostic (1.08e-1)" 50.7 127.2 119.3 13.7 103.4 13.0 41.9 104.6 110.9 37.9 73.0 62.3 32.3 43.9 18.8 48.8 34.4 23.5 153.4 106.6 107.0 56.8 76.8 30.1 10.8 118.5 127.8 30.1 52.7 66.5 33.4 21.3 118.3 37.1 15.0 29.4 55.0 29.7 384.4 55.3 35.2 20.0 124.9 27.9 46.7 94.8 132.1 12.3 41.6 392.3 8.3 47.4 42.7 95.0 49.9 22.2 10.3 29.6 34.6 32.8 10.7 68.2 67.9 32.4 56.1 7.7 39.3 11.7 52.6 69.9 75.4 22.5 15.0 36.2 16.0 14.0 56.8 5.9 60.3 12.1 26.8 6.3 17.7 30.8 38.5 40.6 13.9 36.2 21.3 10.7 14.5 14.5 23.6 21.2 9.2 14.1 4.6 12.9 72.2 7.9 18.0 9.4 20.1 11.5 37.8 14.8 74.4 24.2 20.8 12.3 8.0 21.6 32.6 29.1 14.9 49.2 9.7 16.7 3.6 5.4 63.1 17.9 14.0 3.6 1.6 3.7 0.8 1.1 1.0 0.2 0.7 1.1 0.5 1.4 0.5 0.8 8.1 0.6 3.9 1.0 1.5 0.6 119.3 103.4 104.6 110.9 106.6 107.0 118.5 127.8 118.3 124.9 132.1 95.0 38.7 22.4 19.2 16.3 9.1 15.7 36.0 7.9 10.8 50.1 31.5 24.4 1.1 37.1 9.2 44.1 37.5 26.3 9.2 107.4 80.3 24.0 77.7 22.3 16.1 48.5 20.0 56.0 27.2 28.0 31.8 27.4 12.2 26.4 0.0 36.7 84.3 110.5 23.7 28.6 24.4 30.2 12.2 27.1 16.3 151.4 35.4 22.7 21.4 25.3 10.1 69.7 12.3 8.5 14.3 56.6 67.9 56.8 27.0 67.5 66.9 109.2 7.6 69.0 85.5 30.9 32.2 120.8 24.6 19.3 24.0 34.2 10.6 34.2 24.4 47.9 PITPNM3 "ACKR6, CORD5, NIR1, RDGBA3" ENSG00000091622 "PITPNM family member 3" Q9BZ71 17 6451263-6556555 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cone-rod dystrophy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 60.8" "Cell type enhanced" "Detected in many" "Excitatory neurons: 20.5;Hepatic stellate cells: 27.8;Inhibitory neurons: 24.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 23 "neutrophil: 2.2" "Lineage enriched" "Detected in single" 23 "granulocytes: 2.2" "Cell line enhanced" "Detected in some" "HaCaT: 17.7;HeLa: 14.8;hTCEpi: 50.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022432, HPA059005" Enhanced Approved "Plasma membrane" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 64: Macrophages - Immune response" "Cluster 30: Epithelial cell lines - Translation" "Cluster 44: Endometrium - Transcription" "Plasma membrane" "HPA022432: AB_2670936, HPA059005: AB_2683876" "unprognostic (2.97e-2)" "unprognostic (8.60e-3)" "unprognostic (1.45e-2)" "unprognostic (1.52e-1)" "unprognostic (2.69e-2)" "prognostic favorable (3.67e-6)" "unprognostic (1.25e-2)" "unprognostic (6.86e-2)" "unprognostic (3.66e-2)" "unprognostic (3.01e-2)" "unprognostic (2.99e-3)" "unprognostic (3.58e-2)" "unprognostic (2.41e-1)" "unprognostic (9.60e-2)" "unprognostic (1.61e-1)" "unprognostic (3.55e-1)" "unprognostic (2.63e-1)" 1.3 3.1 23.6 1.1 20.7 0.1 1.4 7.3 23.7 3.1 0.0 7.5 1.3 1.9 3.4 17.8 4.3 1.8 1.3 19.1 1.6 2.8 1.4 3.1 0.2 0.0 0.8 26.6 1.7 0.9 2.0 0.1 0.0 4.5 3.7 7.9 4.7 8.9 0.9 17.0 2.7 4.0 0.5 60.8 6.8 4.2 4.6 0.4 2.7 0.9 1.1 1.7 6.4 13.0 9.0 0.9 0.7 0.3 0.1 0.2 0.7 0.6 0.2 0.8 0.6 0.6 6.3 0.2 3.3 0.2 2.4 17.7 0.3 3.7 0.3 0.3 0.6 0.1 14.8 0.2 0.9 0.4 0.6 0.2 50.4 1.0 2.8 4.1 0.4 0.7 0.1 0.0 0.6 0.8 0.1 0.2 1.0 4.5 2.5 0.3 1.9 0.1 1.2 0.1 0.4 0.5 8.1 3.8 0.2 0.3 1.3 0.0 0.3 0.4 3.2 0.6 2.1 0.5 0.2 0.0 0.6 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 23.6 20.7 7.3 23.7 19.1 1.6 0.0 0.8 0.0 0.5 4.6 13.0 1.5 3.2 16.5 3.6 0.2 5.1 2.2 9.6 2.2 13.5 1.3 1.8 2.0 4.3 11.4 1.8 4.2 0.1 0.2 11.1 0.0 2.2 4.1 10.1 1.0 7.8 1.2 0.0 20.5 0.5 0.0 1.6 4.6 10.3 5.7 1.6 27.8 1.6 0.1 5.0 24.2 3.7 4.1 4.1 0.4 1.8 0.6 0.3 0.0 2.8 0.1 0.6 0.0 0.5 1.6 10.0 5.7 0.0 0.2 2.4 0.6 0.3 7.8 11.9 0.0 12.0 1.9 3.4 1.7 11.5 5.8 0.1 0.7 7.1 6.5 5.2 PITX2 "ARP1, Brx1, IGDS, IHG2, IRID2, Otlx2, RGS, RIEG, RIEG1, RS" ENSG00000164093 "Paired like homeodomain 2" Q99697 4 110617423-110642123 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Developmental protein, DNA-binding" "Disease variant, Peters anomaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 42.0;skeletal muscle: 43.2;urinary bladder: 29.8" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 19.2;Fibroblasts: 69.6;Paneth cells: 20.6;Proximal enterocytes: 39.7;Skeletal myocytes: 49.8" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in some" 4 "hypothalamus: 17.8;thalamus: 6.8" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CACO-2: 24.8;HEK 293: 10.5;LHCN-M2: 25.1;RH-30: 20.5" "Group enriched" "Detected in some" 25 "hypothalamus: 5.4;midbrain: 1.5" "HPA050074, HPA062728" Enhanced Nucleoplasm NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 39: CACO-2 - Unknown function" "Cluster 33: Fibroblasts - ECM organization" Nucleoplasm "HPA050074: AB_2681005, HPA062728: AB_2684851" "unprognostic (1.08e-1)" "unprognostic (1.23e-2)" "unprognostic (9.29e-2)" "unprognostic (9.24e-2)" "unprognostic (1.68e-1)" "unprognostic (1.14e-2)" "unprognostic (9.61e-4)" "unprognostic (3.22e-2)" "unprognostic (1.74e-1)" "unprognostic (2.24e-1)" "unprognostic (1.16e-1)" "unprognostic (2.77e-1)" "unprognostic (1.11e-15)" "unprognostic (6.97e-3)" "unprognostic (1.43e-1)" "unprognostic (5.98e-2)" "unprognostic (9.91e-2)" 0.2 0.0 0.0 7.8 0.2 0.0 0.4 0.0 0.0 1.6 0.0 3.8 0.0 0.1 0.0 2.6 0.2 1.1 2.0 0.0 17.8 0.2 0.0 0.0 0.0 0.1 2.8 0.0 0.5 0.0 16.1 42.0 0.2 0.9 0.2 0.0 13.5 0.1 43.2 1.5 3.1 0.5 0.2 0.0 0.5 0.5 6.8 0.0 0.0 12.3 0.0 29.8 3.8 0.0 1.4 2.6 0.0 1.0 2.4 2.1 4.0 0.8 0.4 2.6 2.0 24.8 0.0 0.0 5.2 5.1 3.2 0.4 0.1 0.0 1.4 0.0 10.5 0.0 2.0 0.0 8.8 0.0 5.0 2.5 0.2 0.5 0.0 0.8 0.0 2.7 0.6 0.0 25.1 0.7 2.7 0.0 0.4 0.0 0.5 0.0 20.5 0.0 0.4 3.4 0.0 0.0 2.0 3.3 0.3 0.4 0.2 0.0 0.0 3.1 7.5 0.0 4.1 0.1 0.1 1.0 1.8 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 17.8 0.1 2.8 0.2 0.2 6.8 0.0 0.3 0.0 0.0 0.0 0.0 0.6 0.6 0.0 1.2 0.0 0.1 0.3 19.2 0.0 0.1 0.0 0.0 5.8 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.5 1.8 0.0 0.0 0.4 5.7 69.6 0.0 0.0 0.0 0.0 0.0 0.0 7.4 0.0 0.0 9.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 20.6 0.0 0.0 0.2 39.7 2.3 0.0 0.0 0.0 49.8 5.4 2.3 7.0 1.7 0.1 10.5 0.0 0.0 14.1 0.1 PITX3 ASMD ENSG00000107859 "Paired like homeodomain 3" O75364 10 102230186-102241512 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Developmental protein, DNA-binding" "Cataract, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "brain: 5.5;skeletal muscle: 16.5;tongue: 6.0" "Cell type enriched" "Detected in some" 4 "Skeletal myocytes: 22.1" "Not detected" "Not detected" "Region enriched" "Detected in single" 14 "midbrain: 5.5" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 16 "RH-30: 30.3" "Not detected" "Not detected" "Region enhanced" "Detected in some" "midbrain: 9.1" NA NA "Cluster 80: Striated muscle - Unknown function" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 50: Fibroblasts - ECM organization" "unprognostic (8.13e-2)" "unprognostic (4.07e-1)" "unprognostic (5.15e-3)" "unprognostic (6.30e-2)" "unprognostic (1.06e-1)" "unprognostic (6.04e-5)" "unprognostic (6.30e-3)" "unprognostic (2.02e-1)" "unprognostic (6.36e-2)" "unprognostic (2.67e-2)" "unprognostic (3.73e-2)" "unprognostic (1.76e-2)" "unprognostic (6.76e-3)" "unprognostic (4.13e-2)" 1.2 0.0 0.4 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.6 0.1 0.1 0.2 0.0 0.0 0.0 0.0 5.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 16.5 0.0 0.0 0.0 0.1 0.0 0.0 1.0 0.2 0.0 0.0 6.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 30.3 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.1 0.1 0.0 5.5 0.0 0.1 0.2 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.5 0.7 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 5.2 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 22.1 0.3 1.4 1.2 0.0 0.1 0.0 0.0 0.2 0.0 0.0 PJVK DFNB59 ENSG00000204311 Pejvakin Q0ZLH3 2 178451346-178462102 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Hearing "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 20.7" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 6.4;Alveolar cells type 2: 9.1;Distal tubular cells: 3.9;Granulosa cells: 6.1;Theca cells: 4.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 5 "plasmacytoid DC: 2.8" "Lineage enriched" "Detected in single" 5 "dendritic cells: 2.8" "Cell line enhanced" "Detected in many" "SuSa: 6.8" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA042621 Approved Mitochondria No No "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 68: Epididymis - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 7: Non-specific - Mitochondria" Mitochondria "HPA042621: AB_10797503" "unprognostic (4.01e-2)" "unprognostic (4.28e-2)" "unprognostic (1.58e-2)" "unprognostic (2.64e-1)" "unprognostic (7.21e-3)" "unprognostic (9.36e-2)" "unprognostic (1.22e-1)" "unprognostic (1.14e-1)" "unprognostic (8.60e-3)" "unprognostic (4.57e-2)" "unprognostic (1.90e-3)" "unprognostic (9.13e-2)" "prognostic unfavorable (8.92e-4)" "unprognostic (1.22e-1)" "unprognostic (1.47e-1)" "unprognostic (2.41e-2)" "unprognostic (8.06e-3)" 3.0 1.8 6.9 1.3 7.2 1.4 4.8 6.9 10.7 2.7 6.9 1.9 1.2 3.9 7.3 1.2 2.8 2.9 1.4 7.0 7.0 3.2 2.8 1.5 1.9 7.6 7.3 7.1 1.3 1.1 4.1 1.2 7.5 2.8 1.2 6.4 2.7 3.0 3.5 4.2 1.4 2.0 7.3 1.4 1.2 20.7 7.1 1.2 2.5 0.9 1.7 1.9 1.4 7.7 0.2 1.8 2.3 1.9 3.0 3.1 1.2 1.5 1.4 1.2 2.0 0.7 3.1 2.1 1.5 0.9 1.0 0.9 1.7 1.0 0.9 0.7 0.6 0.7 2.9 0.4 3.0 0.6 0.2 3.2 2.2 1.4 3.2 3.8 1.5 4.1 0.4 1.3 1.5 0.5 2.1 1.3 2.8 0.2 0.8 2.7 1.7 1.3 2.0 1.0 1.6 1.3 0.5 0.3 0.6 6.8 0.7 0.7 1.0 1.5 0.6 0.4 0.1 4.3 2.8 0.7 0.7 1.1 0.6 0.1 0.1 0.0 0.1 0.1 0.2 0.3 0.2 0.1 0.0 0.5 0.5 0.3 0.4 0.2 0.0 2.8 0.0 0.0 6.9 7.2 6.9 10.7 7.0 7.0 7.6 7.3 7.5 7.3 7.1 7.7 1.6 6.4 9.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 3.0 2.4 0.0 0.0 1.8 1.8 0.0 1.1 0.5 0.0 3.9 1.4 0.0 1.8 2.6 0.4 0.0 0.0 0.0 0.9 0.5 1.4 0.0 1.6 0.0 6.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 2.6 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.6 4.7 0.0 0.0 PLA2G5 ENSG00000127472 "Phospholipase A2 group V" P39877 1 20028179-20091911 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted secreted proteins, RAS pathway related proteins" "Fatty acid metabolism, Lipid degradation, Lipid metabolism, Phagocytosis, Phospholipid degradation, Phospholipid metabolism" Hydrolase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 132.7;ovary: 47.6" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 75.3;Cone photoreceptor cells: 70.9;Leydig cells: 81.4;Peritubular cells: 73.4;Sertoli cells: 263.0;Smooth muscle cells: 63.1" "Group enriched" "Detected in many" 5 "glioma: 13.0;prostate cancer: 3.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "U-2197: 1.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA053361 Approved "Secreted in other tissues" NA NA "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 18: U-2197 - ECM organization" "Cluster 43: Cardiomyocytes - Nuclear processes" "HPA053361: AB_2682127" "unprognostic (2.78e-2)" "unprognostic (1.14e-2)" "unprognostic (5.68e-3)" "unprognostic (6.16e-2)" "unprognostic (2.01e-2)" "unprognostic (5.93e-2)" "unprognostic (2.12e-2)" "unprognostic (1.02e-1)" "unprognostic (2.15e-2)" "unprognostic (1.12e-1)" "unprognostic (2.02e-1)" "unprognostic (1.70e-3)" "unprognostic (6.00e-5)" "unprognostic (2.87e-2)" "unprognostic (3.00e-1)" "unprognostic (1.54e-1)" "unprognostic (4.97e-3)" 8.9 1.5 8.7 1.4 10.9 0.0 3.4 10.5 14.4 1.2 22.1 33.7 0.7 1.8 0.9 4.4 6.4 2.0 132.7 9.1 9.7 0.1 6.1 8.0 0.6 10.2 10.9 47.6 0.9 0.0 0.8 4.7 9.2 14.9 2.3 18.9 2.7 7.7 0.5 1.7 3.0 3.3 9.5 1.6 6.3 10.1 11.8 0.0 2.4 0.3 1.2 17.6 1.7 8.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.7 10.9 10.5 14.4 9.1 9.7 10.2 10.9 9.2 9.5 11.8 8.6 0.7 0.0 0.5 25.8 0.0 0.4 0.0 0.0 0.0 11.6 0.2 1.3 75.3 0.0 0.0 0.0 70.9 0.1 0.0 0.0 0.0 0.0 1.3 0.0 0.0 5.1 0.0 0.0 0.2 0.0 0.1 30.8 0.0 0.0 0.0 6.7 10.8 0.1 0.3 0.0 0.2 0.0 0.0 1.2 0.7 4.9 81.4 0.5 0.0 1.9 0.0 30.8 0.0 0.5 0.1 0.0 0.0 73.4 0.0 1.3 0.0 0.0 0.0 32.1 263.0 0.5 63.1 0.6 0.7 0.0 0.4 0.3 0.1 0.0 0.0 0.1 PLA2G6 "iPLA2, iPLA2beta, NBIA2, PARK14, PNPLA9" ENSG00000184381 "Phospholipase A2 group VI" O60733 22 38111495-38214778 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Chemotaxis, Lipid metabolism, Phospholipid metabolism" "Calmodulin-binding, Hydrolase" "Disease variant, Dystonia, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 28.5;Spermatocytes: 44.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "NK-cell: 3.7" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HEL: 39.1;HMC-1: 25.6;U-266/70: 20.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001171 Approved Approved "Centriolar satellite,Cytosol" NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 43: Testis - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 66: Spermatocytes - Spermatogenesis" "Centriolar satellite, Cytosol" "HPA001171: AB_1079145" "unprognostic (5.26e-2)" "prognostic favorable (7.29e-4)" "unprognostic (8.74e-2)" "unprognostic (6.27e-2)" "unprognostic (3.83e-1)" "unprognostic (3.70e-3)" "unprognostic (8.67e-3)" "unprognostic (9.55e-2)" "unprognostic (3.48e-1)" "unprognostic (1.91e-1)" "unprognostic (2.37e-3)" "unprognostic (4.95e-2)" "unprognostic (1.94e-3)" "unprognostic (1.01e-1)" "unprognostic (3.00e-1)" "unprognostic (1.48e-1)" "prognostic favorable (1.55e-4)" 20.0 22.2 14.1 4.6 16.6 12.2 19.5 15.2 20.3 24.9 12.3 11.4 9.2 17.8 10.6 10.3 26.2 13.2 9.5 14.3 13.7 24.0 13.3 10.4 8.5 17.2 15.0 24.3 16.1 6.7 17.7 4.1 19.5 24.9 2.8 8.3 15.9 9.2 10.7 17.2 12.5 3.4 15.3 17.1 13.2 42.1 15.4 11.7 51.8 4.4 4.6 13.2 14.4 25.5 0.8 1.3 2.6 6.3 8.0 5.5 9.8 0.9 1.0 0.5 1.2 3.2 2.4 5.9 6.7 1.3 0.9 3.5 2.2 2.5 0.3 9.2 11.1 39.1 3.4 3.5 3.1 2.6 25.6 13.3 3.7 2.3 4.6 6.6 0.8 11.7 8.0 13.3 0.7 3.1 8.5 3.0 3.4 2.7 1.3 6.5 1.2 6.1 2.8 5.9 7.1 1.9 1.9 3.1 6.7 3.9 4.1 2.4 0.6 2.1 4.5 0.9 0.6 20.6 2.7 4.0 4.0 3.2 2.0 1.4 0.1 0.0 1.0 0.0 0.7 0.5 1.0 1.5 0.4 0.3 0.4 1.2 0.6 3.7 0.2 1.3 1.6 0.7 14.1 16.6 15.2 20.3 14.3 13.7 17.2 15.0 19.5 15.3 15.4 25.5 5.6 3.2 2.7 19.9 4.6 3.1 3.5 4.0 4.6 9.9 7.4 6.5 2.0 4.3 5.0 12.9 4.2 3.3 11.1 11.3 0.0 2.1 28.5 9.5 4.4 3.1 11.4 7.4 6.4 1.0 2.7 3.3 11.2 8.7 0.0 10.6 3.6 3.5 1.7 15.2 5.9 8.6 2.0 1.0 0.8 18.3 5.9 2.1 1.8 4.7 2.3 4.9 8.2 4.5 25.2 1.1 12.6 3.8 4.7 2.9 21.9 1.9 7.6 7.5 6.6 2.6 3.4 44.5 7.7 4.1 3.4 4.9 6.6 6.8 8.4 2.1 PLCB1 "KIAA0581, PLC-I, PLC154" ENSG00000182621 "Phospholipase C beta 1" Q9NQ66 20 8077251-8968360 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Lipid degradation, Lipid metabolism" "Hydrolase, Transducer" Epilepsy "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 74.3" "Cell type enhanced" "Detected in many" "Astrocytes: 563.5;Excitatory neurons: 2569.1;Inhibitory neurons: 1774.0;Oligodendrocyte precursor cells: 783.1" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in many" "cerebral cortex: 74.3" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "CACO-2: 45.5;Hep G2: 68.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004275, CAB005334, HPA034743, HPA057910" Enhanced Approved "Plasma membrane" NA NA 6600 "Cluster 16: MAIT-cells - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" "CAB004275: AB_628118, CAB005334: AB_632196, HPA034743: AB_2674311, HPA057910: AB_2683552" "unprognostic (2.32e-1)" "unprognostic (1.02e-1)" "unprognostic (6.63e-2)" "unprognostic (9.77e-2)" "unprognostic (9.87e-2)" "unprognostic (2.37e-1)" "unprognostic (1.27e-4)" "unprognostic (1.13e-1)" "unprognostic (3.16e-2)" "unprognostic (1.91e-1)" "unprognostic (7.12e-3)" "unprognostic (6.57e-2)" "unprognostic (2.87e-3)" "unprognostic (3.20e-2)" "unprognostic (4.41e-2)" "unprognostic (1.71e-2)" "unprognostic (2.12e-1)" 9.3 8.9 11.7 5.7 52.3 4.8 7.6 0.0 74.3 8.2 0.0 18.1 7.2 9.3 3.5 5.4 9.6 8.5 11.7 17.4 0.0 13.2 4.3 5.0 1.8 0.0 0.1 3.7 14.7 44.3 4.3 19.6 0.0 13.4 4.1 7.1 29.0 18.8 14.4 2.6 5.7 8.1 0.0 3.6 8.0 3.0 9.8 6.8 3.8 11.0 0.9 15.9 6.7 23.8 0.2 1.2 4.8 0.3 8.7 16.1 6.3 20.2 13.1 5.2 3.1 45.5 5.0 2.2 8.2 3.9 0.3 0.0 3.7 0.0 3.8 0.0 4.4 1.0 3.5 68.7 2.2 1.1 0.7 1.1 0.8 7.1 0.0 6.5 10.6 13.0 7.1 26.0 0.1 6.2 1.0 3.3 15.0 10.6 6.6 14.7 0.0 12.1 4.0 16.8 16.9 7.2 0.1 4.1 0.9 17.1 19.9 6.6 1.9 16.8 7.5 1.3 12.7 19.4 24.5 33.9 8.6 12.6 29.5 0.3 1.3 1.2 1.4 0.3 2.0 0.1 0.4 0.5 0.1 0.2 0.2 0.4 0.8 1.1 0.1 0.3 0.1 0.2 11.7 52.3 0.0 74.3 17.4 0.0 0.0 0.1 0.0 0.0 9.8 23.8 74.8 0.0 3.4 563.5 1.1 1.9 20.8 2.3 8.0 7.6 8.1 23.2 26.9 7.2 2.6 16.5 0.0 2.4 16.8 1.3 33.2 1.2 9.9 42.1 5.1 54.6 0.0 6.5 2569.1 13.4 2.8 25.8 3.6 83.6 1.3 0.2 26.4 2.8 0.8 1.7 1774.0 2.1 0.0 8.2 1.2 4.3 3.4 9.1 7.2 211.7 12.2 18.2 15.5 783.1 34.8 1.8 0.5 3.8 6.1 20.2 0.1 9.4 9.9 4.1 0.0 7.4 13.3 4.7 5.6 2.5 1.7 1.8 15.4 1.1 1.2 18.9 PLD3 HU-K4 ENSG00000105223 "Phospholipase D family member 3" Q8IV08 19 40348456-40380439 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Immunity, Inflammatory response" "Exonuclease, Hydrolase, Nuclease" "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "pituitary gland: 711.9" "Cell type enhanced" "Detected in all" "Hofbauer cells: 688.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 5 "basophil: 1727.4" "Lineage enriched" "Detected in all" 7 "granulocytes: 1727.4" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012800, CAB020812" Approved Approved "Nucleoplasm,Endoplasmic reticulum,Cytosol" NA NA 450000 "Cluster 10: Basophils - Unknown function" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 3: HMC-1 - Innate immune response" "Cluster 4: Macrophages - Innate immune response" "Endoplasmic reticulum, Cytosol" Nucleoplasm "CAB020812: , HPA012800: AB_1855330" "unprognostic (1.11e-1)" "unprognostic (1.06e-1)" "unprognostic (1.64e-3)" "unprognostic (2.56e-3)" "unprognostic (2.06e-3)" "unprognostic (2.68e-1)" "unprognostic (4.52e-2)" "unprognostic (3.89e-2)" "unprognostic (1.09e-1)" "unprognostic (4.60e-2)" "prognostic favorable (6.44e-4)" "unprognostic (4.34e-2)" "prognostic favorable (2.21e-4)" "unprognostic (3.49e-2)" "unprognostic (2.10e-1)" "unprognostic (1.38e-2)" "unprognostic (6.42e-2)" 169.3 200.0 143.3 78.4 159.7 48.3 138.4 46.0 229.7 139.4 54.0 131.4 71.7 155.7 84.7 84.9 133.5 96.7 206.1 202.5 294.4 130.2 121.3 181.5 98.1 132.4 128.5 199.0 151.0 105.9 711.9 123.4 137.9 133.4 49.2 51.4 138.7 106.2 105.1 120.5 105.3 79.1 63.8 197.0 126.5 77.7 197.7 44.3 120.8 82.3 41.4 126.2 126.0 129.6 85.6 257.8 163.7 259.1 444.2 210.2 124.5 206.5 208.6 146.4 166.6 49.4 93.8 36.9 211.0 180.9 47.8 39.3 39.9 81.2 63.5 138.4 145.3 39.9 82.1 63.2 302.7 16.8 435.1 402.5 167.0 112.1 76.6 244.2 125.0 59.3 142.5 144.5 106.7 111.5 29.5 79.6 107.4 138.7 52.8 37.0 124.5 154.2 75.2 63.2 116.7 193.9 99.0 60.6 113.8 169.5 83.6 283.2 222.3 122.8 58.5 105.6 47.0 148.9 173.3 38.8 197.7 66.2 77.9 1727.4 256.7 378.7 75.0 129.5 62.0 34.4 59.5 67.7 235.0 28.1 60.8 61.3 25.7 102.3 64.2 34.7 64.5 208.6 143.3 159.7 46.0 229.7 202.5 294.4 132.4 128.5 137.9 63.8 197.7 129.6 66.7 32.1 69.6 59.4 27.0 35.4 93.6 263.1 39.9 101.5 45.9 61.2 22.0 45.8 90.4 57.0 33.3 158.2 27.2 42.5 21.5 52.5 8.7 32.0 49.8 53.9 72.8 18.7 99.1 58.3 107.2 158.8 38.2 31.5 60.3 134.7 88.2 43.1 688.4 121.1 113.4 41.3 126.1 280.9 59.1 15.7 151.6 261.3 92.5 50.6 54.2 94.1 35.0 53.3 70.2 54.3 42.6 143.7 85.8 57.9 78.8 37.1 35.2 47.6 19.7 73.1 59.7 24.2 67.9 32.4 33.4 195.9 28.8 114.1 41.6 68.2 PLEKHG2 "ARHGEF42, CLG, FLJ00018" ENSG00000090924 "Pleckstrin homology and RhoGEF domain containing G2" Q9H7P9 19 39412669-39428415 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Guanine-nucleotide releasing factor" "Disease variant, Leukodystrophy, Mental retardation, Tumor suppressor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Skeletal myocytes: 64.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "REH: 86.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017973, HPA048054" Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 64: Macrophages - Immune response" "Cluster 12: NES - Nervous system development" "Cluster 50: Fibroblasts - ECM organization" Nucleoplasm Cytosol "HPA017973: AB_2669719, HPA048054: AB_2680241" "unprognostic (3.55e-1)" "unprognostic (6.73e-2)" "prognostic unfavorable (3.53e-4)" "unprognostic (3.97e-2)" "unprognostic (1.54e-1)" "unprognostic (1.41e-3)" "unprognostic (1.24e-2)" "unprognostic (4.48e-2)" "unprognostic (1.39e-1)" "unprognostic (8.09e-2)" "unprognostic (2.10e-1)" "unprognostic (4.99e-1)" "prognostic unfavorable (3.79e-8)" "unprognostic (8.01e-2)" "unprognostic (3.90e-2)" "unprognostic (7.52e-2)" "unprognostic (1.63e-1)" 32.6 10.7 4.6 22.8 3.8 22.1 20.3 4.6 7.5 28.2 11.3 24.5 8.1 31.2 4.4 10.1 24.9 17.4 25.6 4.3 3.7 27.7 8.0 42.2 20.7 7.1 4.4 20.1 7.1 5.2 12.2 23.0 5.1 21.0 5.2 4.6 8.4 15.1 6.3 9.0 18.9 18.5 4.7 33.4 15.6 15.7 9.3 21.1 19.1 4.9 18.3 20.9 17.4 5.2 8.5 40.8 73.0 39.9 6.9 9.0 10.6 21.9 17.3 14.9 12.8 26.5 14.9 14.7 15.8 28.8 12.4 2.8 11.1 19.4 7.9 49.3 10.2 19.3 23.5 12.4 11.9 2.2 23.1 20.7 3.3 17.9 8.7 25.8 19.3 41.7 13.2 16.9 24.1 17.0 24.2 7.5 17.3 7.8 3.9 86.1 8.9 4.6 12.7 15.4 2.0 23.6 4.9 1.8 7.0 25.2 21.9 21.8 24.8 38.8 30.0 14.5 14.4 12.6 4.1 21.4 21.6 8.7 22.0 1.3 0.5 0.1 1.4 0.2 0.9 1.2 0.7 0.8 0.3 1.1 1.0 1.2 0.8 0.4 0.7 1.4 1.3 1.1 4.6 3.8 4.6 7.5 4.3 3.7 7.1 4.4 5.1 4.7 9.3 5.2 30.4 6.4 27.4 1.6 9.7 4.0 5.5 2.9 6.8 0.6 4.6 11.7 6.4 2.8 6.4 0.0 0.0 0.8 8.7 5.0 0.0 5.6 14.2 11.9 20.1 17.7 1.2 1.7 0.5 4.9 2.9 16.9 13.3 30.4 2.5 6.9 8.2 0.8 9.9 0.0 0.8 3.7 0.0 12.8 21.1 19.8 7.2 25.6 5.4 2.8 5.4 1.1 4.1 2.5 0.3 4.2 2.1 8.2 9.1 3.0 2.6 0.2 2.2 2.4 6.6 64.5 26.8 2.5 4.1 6.5 2.8 1.1 12.2 2.4 3.1 1.9 PLEKHG5 "GEF720, KIAA0720, Syx, Tech" ENSG00000171680 "Pleckstrin homology and RhoGEF domain containing G5" O94827 1 6467122-6520074 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 57.4;skin 1: 102.5" "Cell type enhanced" "Detected in many" "Excitatory neurons: 17.4" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "cerebellum: 57.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "NB-4: 32.1;TIME: 30.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049570 Uncertain Approved Nucleoplasm NA NA "Cluster 61: Skin - Cornification" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Nucleoplasm "HPA049570: AB_2680818" "unprognostic (5.59e-2)" "unprognostic (1.33e-1)" "unprognostic (2.47e-1)" "unprognostic (2.81e-1)" "unprognostic (1.50e-3)" "unprognostic (5.10e-2)" "unprognostic (1.02e-1)" "unprognostic (5.46e-2)" "unprognostic (4.40e-2)" "unprognostic (1.02e-2)" "unprognostic (4.85e-1)" "unprognostic (2.70e-2)" "unprognostic (1.28e-3)" "unprognostic (4.85e-1)" "unprognostic (1.20e-1)" "unprognostic (3.13e-1)" "unprognostic (4.85e-2)" 18.7 15.0 4.4 2.9 2.6 0.6 12.0 57.4 16.6 14.0 0.0 7.3 6.4 7.5 1.9 21.6 8.6 7.3 16.4 13.0 0.0 6.5 1.8 6.0 5.0 0.0 0.0 7.5 5.1 4.4 43.3 12.4 1.8 9.9 3.5 3.4 9.3 7.2 6.8 102.5 8.4 3.9 0.0 50.9 4.4 5.4 0.0 2.0 7.2 3.0 3.3 5.9 14.3 0.0 7.1 2.7 11.9 9.4 1.5 4.2 3.1 8.4 7.0 3.2 2.1 6.9 18.8 0.3 22.6 2.8 4.9 22.6 2.2 23.7 1.3 16.5 3.0 0.0 15.1 2.9 1.9 0.0 1.3 5.5 10.2 8.1 12.5 17.4 24.9 1.7 0.0 1.5 0.6 5.0 0.5 32.1 4.9 2.3 23.8 0.1 2.7 2.3 6.3 3.1 10.5 25.2 1.1 8.2 1.5 5.3 8.2 0.5 30.3 8.1 5.0 0.0 6.6 0.1 0.0 2.4 9.2 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.4 2.6 57.4 16.6 13.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 10.6 0.0 1.5 1.0 0.2 7.4 2.3 4.7 8.0 1.4 1.4 2.2 4.1 1.5 3.6 3.7 2.1 2.6 0.1 4.2 0.0 1.3 8.6 2.5 5.9 9.8 3.5 0.4 17.4 1.3 4.0 1.9 3.1 3.2 0.0 4.0 7.5 0.3 5.3 1.7 9.6 6.4 6.1 0.8 1.3 5.7 1.8 2.4 0.0 7.5 0.0 9.7 0.0 2.0 1.2 5.1 5.6 8.6 0.4 3.8 4.1 0.4 2.7 1.5 13.1 2.1 1.7 2.1 5.1 10.8 14.5 1.9 0.7 2.5 2.8 5.8 PLP1 "GPM6C, PLP, SPG2" ENSG00000123560 "Proteolipid protein 1" P60201 X 103773718-103792619 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted membrane proteins" "Cancer-related genes, Disease variant, Hereditary spastic paraplegia, Leukodystrophy, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 7 "brain: 7004.9" "Cell type enriched" "Detected in some" 12 "Oligodendrocytes: 4822.5" "Group enriched" "Detected in many" 22 "glioma: 160.5;melanoma: 75.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "SK-MEL-30: 241.0;WM-115: 139.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004128 Enhanced NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA004128: AB_1079635" "unprognostic (5.72e-2)" "unprognostic (1.77e-2)" "unprognostic (2.27e-2)" "unprognostic (4.09e-3)" "unprognostic (1.32e-1)" "unprognostic (3.95e-2)" "unprognostic (2.57e-2)" "unprognostic (1.02e-1)" "unprognostic (5.92e-2)" "unprognostic (2.28e-2)" "unprognostic (1.21e-1)" "unprognostic (1.62e-5)" "unprognostic (4.91e-2)" "unprognostic (1.86e-1)" "unprognostic (3.46e-2)" "unprognostic (1.16e-2)" 7.3 15.7 2252.5 4.2 4296.1 0.1 5.4 4251.8 3472.7 17.8 1056.0 73.9 6.3 6.8 6.7 9.9 7.3 9.6 30.1 2314.1 2859.4 2.9 2.0 1.2 0.4 5976.3 3571.3 5.7 2.5 83.1 6.4 0.0 5342.5 21.1 14.9 7.5 6.7 30.0 2.4 24.4 22.4 22.7 3919.9 0.5 15.4 33.5 3592.5 3.8 3.4 6.8 0.4 12.9 21.8 7004.9 0.2 0.0 20.7 0.1 0.0 0.3 0.0 0.0 0.4 0.0 0.8 1.9 0.0 0.0 0.2 0.7 0.1 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.4 4.0 0.0 0.2 0.0 0.9 0.0 0.1 0.0 2.8 0.0 0.0 0.1 0.0 37.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 241.0 6.3 0.1 0.2 0.0 0.1 0.4 0.1 0.2 0.0 0.3 0.2 4.0 0.0 139.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 2252.5 4296.1 4251.8 3472.7 2314.1 2859.4 5976.3 3571.3 5342.5 3919.9 3592.5 7004.9 0.5 0.0 0.0 23.8 0.1 15.9 0.3 0.0 6.2 1.7 0.2 0.5 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.6 0.0 0.0 9.7 0.0 0.0 13.3 0.0 0.0 0.0 188.3 3.3 0.0 0.1 0.0 11.2 0.0 0.0 0.0 5.8 3.1 7.5 0.8 396.6 17.8 0.0 30.7 0.0 31.2 4822.5 0.0 0.0 3.0 0.0 0.8 0.0 0.0 0.0 1.1 0.0 3.1 2.4 0.6 0.3 0.8 2.6 0.0 0.2 5.6 0.0 0.1 PLPBP PROSC ENSG00000147471 "Pyridoxal phosphate binding protein" O94903 8 37762595-37779768 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal tubular cells: 101.8;Exocrine glandular cells: 49.8;Hofbauer cells: 47.3;Proximal tubular cells: 82.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017033, HPA023646, HPA023733" Approved Enhanced Cytosol NA NA 34000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 8: Non-specific - Mitochondria" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 7: Non-specific - Mitochondria" Cytosol "CAB017033: , HPA023646: AB_1855741, HPA023733: AB_1855742" "unprognostic (1.55e-2)" "unprognostic (2.17e-2)" "unprognostic (2.14e-2)" "unprognostic (2.95e-2)" "unprognostic (1.34e-1)" "unprognostic (2.35e-2)" "unprognostic (2.36e-1)" "unprognostic (7.78e-3)" "unprognostic (1.80e-1)" "unprognostic (4.28e-2)" "unprognostic (2.83e-2)" "unprognostic (2.59e-2)" "unprognostic (9.41e-3)" "unprognostic (3.16e-2)" "unprognostic (3.99e-2)" "unprognostic (2.90e-1)" "unprognostic (7.85e-2)" 34.2 23.1 22.2 21.2 24.3 14.6 23.3 25.3 27.1 22.1 26.8 47.2 34.5 19.2 23.3 20.2 27.5 19.1 39.2 24.0 25.0 58.5 78.2 25.7 25.0 22.8 24.9 24.7 40.3 37.4 16.2 20.1 23.7 20.2 37.9 10.9 28.3 27.8 46.4 17.0 37.3 25.9 23.7 25.0 33.5 8.4 24.5 27.4 31.8 42.1 29.0 22.9 16.1 28.6 50.3 45.4 35.1 32.0 25.9 31.1 31.6 55.2 45.8 34.7 38.9 51.6 24.3 58.4 61.9 39.9 55.5 41.4 65.4 52.5 56.6 49.9 34.3 79.4 16.4 51.7 51.6 36.8 52.5 22.9 49.8 33.0 52.0 37.6 52.3 78.3 42.8 42.1 28.7 34.8 116.4 32.4 43.0 92.8 41.9 73.6 46.6 34.8 56.5 60.0 21.5 25.1 45.4 20.0 56.8 25.4 44.2 48.6 52.1 19.1 60.7 69.8 38.1 43.3 90.9 43.0 27.4 51.8 35.0 164.3 109.6 136.1 85.6 130.0 90.0 77.8 87.8 83.6 115.2 61.9 77.0 74.3 46.9 75.9 147.4 66.5 116.7 110.2 22.2 24.3 25.3 27.1 24.0 25.0 22.8 24.9 23.7 23.7 24.5 28.6 35.9 9.6 26.5 0.0 6.7 0.0 0.0 0.0 0.0 0.0 27.8 23.0 0.0 0.0 8.1 31.3 0.0 21.2 20.0 0.0 101.8 38.2 0.0 12.8 20.7 13.5 0.0 0.0 0.0 49.8 31.6 13.9 0.0 19.6 12.6 14.8 0.0 0.0 47.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 18.9 0.0 0.0 11.9 0.0 0.0 0.0 0.0 33.2 0.0 0.0 1.8 0.0 0.0 82.2 13.8 0.0 0.0 0.0 11.1 0.0 0.0 0.0 0.0 12.9 9.8 17.1 0.0 0.0 PLS1 "I-plastin, Plastin-1" ENSG00000120756 "Plastin 1" Q14651 3 142596393-142713664 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Actin-binding "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 7 "intestine: 315.6" "Cell type enhanced" "Detected in many" "Distal enterocytes: 471.4;Intestinal goblet cells: 147.9;Paneth cells: 200.5;Proximal enterocytes: 335.1" "Cancer enhanced" "Detected in many" "colorectal cancer: 36.0" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in many" 5 "granulocytes: 2.6;NK-cells: 3.2;T-cells: 2.6" "Cell line enhanced" "Detected in many" "A-431: 90.0;BEWO: 112.3;OE19: 166.4;RPTEC TERT1: 143.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA055744, HPA061936" Enhanced NA NA 56000000 "Cluster 15: NK-cells - Transcription" "Cluster 9: Intestine - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA055744: AB_2682903, HPA061936: " "unprognostic (1.29e-1)" "unprognostic (2.61e-1)" "unprognostic (3.15e-3)" "unprognostic (2.22e-2)" "unprognostic (1.20e-1)" "unprognostic (1.41e-2)" "unprognostic (1.13e-1)" "unprognostic (6.82e-2)" "unprognostic (2.33e-1)" "unprognostic (7.78e-2)" "prognostic unfavorable (4.84e-4)" "unprognostic (3.14e-2)" "prognostic favorable (8.76e-6)" "unprognostic (1.99e-2)" "unprognostic (8.64e-2)" "unprognostic (7.22e-2)" "unprognostic (3.82e-2)" 1.6 3.9 0.8 18.8 1.3 7.4 5.7 2.7 2.2 10.1 11.7 144.2 191.6 3.3 3.1 9.6 7.7 27.7 1.2 1.1 1.4 26.7 27.5 14.8 1.7 3.3 0.3 0.9 12.2 15.7 6.2 1.5 3.2 3.1 139.1 24.9 9.1 1.9 0.9 3.6 315.6 4.3 0.3 0.9 45.8 7.5 0.4 5.9 7.7 0.9 2.9 19.6 3.7 1.4 90.0 69.2 4.8 10.4 0.7 0.0 112.3 1.7 2.3 9.4 20.1 31.7 68.8 15.2 35.8 0.1 31.9 18.9 18.8 28.7 20.0 5.5 27.0 27.2 10.2 11.4 0.9 13.0 1.7 0.1 4.7 17.8 11.4 14.8 4.5 16.4 11.8 1.7 1.1 21.0 21.4 7.0 18.9 166.4 25.9 8.7 20.3 12.7 143.6 81.7 24.1 9.7 10.0 7.0 7.8 13.3 55.6 2.2 1.2 1.1 11.3 3.5 21.3 12.7 12.6 18.1 3.2 12.8 3.5 1.9 0.2 2.6 1.5 0.2 2.0 0.3 1.8 2.0 0.4 0.3 2.2 2.6 1.8 3.2 0.2 0.5 1.3 1.0 0.8 1.3 2.7 2.2 1.1 1.4 3.3 0.3 3.2 0.3 0.4 1.4 0.6 54.5 38.0 1.3 1.6 2.9 4.1 23.2 2.8 3.4 9.7 4.2 3.1 54.3 46.8 44.1 16.7 5.8 0.7 471.4 21.5 21.8 64.3 22.2 1.8 0.7 53.9 5.9 18.7 34.0 1.9 1.1 50.0 26.8 8.9 32.3 1.1 31.5 0.6 5.0 25.2 147.9 24.4 1.6 1.0 20.5 1.2 1.4 1.8 5.6 0.8 2.8 0.0 4.0 3.1 70.2 200.5 0.0 2.8 6.8 335.1 40.6 42.2 13.4 0.0 1.2 1.9 4.6 4.1 7.6 3.3 1.4 1.8 1.3 85.2 20.7 PMP2 "FABP8, M-FABP, MP2" ENSG00000147588 "Peripheral myelin protein 2" P02689 8 81440326-81447439 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Transport "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 50 "brain: 278.7;choroid plexus: 97.2" "Group enriched" "Detected in some" 16 "Astrocytes: 84.9;Muller glia cells: 48.5;Oligodendrocyte precursor cells: 88.4;Oligodendrocytes: 90.3" "Cancer enriched" "Detected in some" 59 "glioma: 239.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "WM-115: 1.4" "Not detected" "Not detected" "Region enriched" "Detected in all" 9 "spinal cord: 1313.6" NA NA "Cluster 70: Brain - Nervous system development" "Cluster 17: WM-115 - Nervous system development" "Cluster 5: Muller glia cells - Visual perception" "unprognostic (5.87e-2)" "unprognostic (5.81e-2)" "unprognostic (1.12e-2)" "unprognostic (1.95e-1)" "unprognostic (8.03e-3)" "unprognostic (1.10e-2)" "unprognostic (8.45e-2)" "unprognostic (4.43e-2)" "unprognostic (7.21e-2)" "unprognostic (4.41e-1)" "unprognostic (3.27e-3)" 1.8 1.4 155.1 1.4 168.0 0.0 0.7 231.4 193.1 1.3 97.2 1.4 0.4 0.1 1.8 0.8 0.3 1.1 2.0 146.1 206.4 0.4 0.2 0.1 0.0 278.7 243.1 0.2 0.4 0.0 0.7 0.0 257.4 1.8 0.7 0.2 1.0 3.7 0.3 0.3 0.6 0.3 247.1 0.0 0.6 0.1 214.0 0.0 0.3 0.8 0.0 0.9 1.1 275.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 155.1 168.0 231.4 193.1 146.1 206.4 278.7 243.1 257.4 247.1 214.0 275.2 1.4 0.0 0.0 84.9 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.8 0.0 0.0 0.4 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 4.7 0.0 48.5 0.0 88.4 90.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.8 0.2 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 PMP22 "CMT1A, GAS3, HMSNIA, HNPP, Sp110" ENSG00000109099 "Peripheral myelin protein 22" Q01453 17 15229773-15272292 "Cancer-related genes, Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Cancer-related genes, Charcot-Marie-Tooth disease, Deafness, Dejerine-Sottas syndrome, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Fibroblasts: 404.1;Hofbauer cells: 558.3;Leydig cells: 324.3;Melanocytes: 343.3;Proximal enterocytes: 580.6;Skeletal myocytes: 288.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "basophil: 32.2;eosinophil: 43.0;plasmacytoid DC: 23.8" "Group enriched" "Detected in many" 22 "dendritic cells: 23.8;granulocytes: 43.0" "Cell line enhanced" "Detected in many" "ASC diff: 383.5;HMC-1: 263.7;SuSa: 333.9;WM-115: 448.8" "Intracellular and membrane" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 17: WM-115 - Nervous system development" "Cluster 33: Fibroblasts - ECM organization" "unprognostic (3.00e-1)" "unprognostic (1.65e-1)" "unprognostic (2.21e-1)" "unprognostic (4.63e-1)" "unprognostic (5.57e-3)" "unprognostic (2.28e-2)" "unprognostic (1.90e-1)" "unprognostic (1.65e-1)" "unprognostic (3.74e-1)" "unprognostic (4.33e-2)" "unprognostic (7.70e-2)" "unprognostic (1.51e-1)" "prognostic unfavorable (1.73e-4)" "unprognostic (1.83e-2)" "unprognostic (5.45e-2)" "unprognostic (2.88e-1)" "unprognostic (1.08e-2)" 275.6 45.4 113.6 55.1 161.0 4.9 184.5 153.2 140.7 192.2 77.9 212.2 41.7 142.1 36.5 68.2 163.4 106.5 167.6 113.5 129.0 53.5 11.7 208.4 27.8 163.3 144.2 102.9 22.8 10.8 26.3 201.9 159.9 81.2 74.7 6.5 77.5 80.6 252.4 112.7 239.1 122.0 135.0 27.9 96.2 20.7 141.1 17.3 95.3 127.0 21.8 208.9 157.4 216.7 7.0 44.1 61.9 62.2 383.5 167.1 12.6 60.5 68.8 58.7 38.0 48.7 1.1 0.1 7.0 172.3 22.7 0.7 74.0 1.1 15.4 0.2 13.9 4.3 76.7 17.2 201.8 0.1 263.7 126.9 1.1 32.6 1.8 72.1 66.1 2.8 24.5 0.8 33.2 6.1 0.2 2.0 3.5 4.0 74.7 22.0 39.3 0.0 44.6 4.8 0.1 40.6 16.6 0.6 134.2 333.9 0.2 0.5 81.4 12.7 45.7 216.9 62.0 0.5 0.1 0.3 84.7 0.1 448.8 32.2 1.4 43.0 0.0 0.9 0.0 0.0 0.0 0.0 7.6 0.1 0.0 0.1 0.2 0.1 0.2 23.8 0.0 0.9 113.6 161.0 153.2 140.7 113.5 129.0 163.3 144.2 159.9 135.0 141.1 216.7 86.6 28.9 11.5 50.9 2.8 90.1 6.7 6.1 9.6 1.4 43.0 82.7 68.4 4.3 7.4 0.0 0.0 8.8 2.5 9.1 3.9 4.5 17.7 20.1 118.6 148.0 4.8 10.1 3.7 3.3 23.1 404.1 2.6 11.0 119.7 25.0 88.5 0.9 558.3 0.0 1.8 23.8 0.0 23.4 116.8 11.0 324.3 93.0 343.3 29.0 11.8 61.6 0.0 46.8 217.1 1.7 25.2 246.4 1.9 4.9 580.6 0.7 3.0 2.2 230.1 288.8 141.1 3.0 4.8 3.0 103.0 19.0 8.7 49.2 17.9 5.2 PMPCA "Alpha-MPP, CLA1, INPP5E, KIAA0123, SCAR2" ENSG00000165688 "Peptidase, mitochondrial processing subunit alpha" Q10713 9 136410641-136423761 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Disease variant, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021648, HPA063735" Supported Enhanced Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 18: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Mitochondria "HPA021648: AB_1855491, HPA063735: AB_2685108" "unprognostic (9.80e-2)" "unprognostic (1.96e-2)" "unprognostic (4.03e-1)" "unprognostic (1.69e-2)" "unprognostic (4.01e-2)" "unprognostic (8.19e-2)" "unprognostic (6.09e-2)" "unprognostic (1.19e-2)" "unprognostic (1.97e-1)" "unprognostic (3.32e-2)" "prognostic favorable (8.00e-5)" "unprognostic (9.47e-3)" "prognostic favorable (2.14e-6)" "unprognostic (4.27e-3)" "unprognostic (1.57e-2)" "unprognostic (2.40e-1)" "unprognostic (3.54e-2)" 29.2 58.1 27.0 20.6 27.6 31.4 27.1 27.0 34.6 29.2 36.8 32.2 24.8 26.8 10.4 34.5 27.5 17.9 73.2 28.0 27.3 37.3 110.8 25.4 27.1 27.1 27.6 29.3 28.8 26.9 38.8 20.8 27.9 31.8 15.3 8.8 28.4 16.1 69.2 37.6 30.6 15.3 25.6 38.2 35.3 37.8 27.9 21.4 29.4 50.0 17.0 28.0 27.8 26.7 48.7 87.7 41.8 84.5 30.8 45.0 63.2 49.3 39.6 67.2 48.9 101.1 56.5 67.4 50.5 50.3 36.2 110.2 77.9 72.0 30.0 97.2 92.8 54.6 113.2 123.6 53.9 71.7 44.9 66.3 48.9 52.6 27.0 38.2 58.0 61.2 140.2 43.4 42.6 132.1 68.1 90.1 85.4 86.2 82.2 83.0 59.1 149.9 46.3 33.9 85.4 56.1 66.6 92.9 58.6 28.6 127.6 95.5 48.2 47.8 50.7 39.8 63.8 26.2 37.4 73.5 62.9 61.3 43.9 37.4 50.5 36.5 53.2 51.9 51.4 52.5 49.0 57.2 61.7 48.8 57.9 50.2 11.9 67.2 51.5 31.4 52.7 62.2 27.0 27.6 27.0 34.6 28.0 27.3 27.1 27.6 27.9 25.6 27.9 26.7 17.3 16.0 26.7 14.7 24.2 27.5 40.2 65.0 27.9 24.7 19.3 15.2 35.9 15.7 32.8 22.0 22.9 103.1 22.5 28.0 49.0 32.9 24.6 25.6 23.5 21.7 20.8 23.5 13.8 30.7 50.4 23.7 21.9 26.2 24.7 44.2 19.6 57.2 37.8 18.5 11.4 24.2 44.7 19.2 14.6 15.8 19.0 17.4 16.0 6.5 21.0 22.9 14.4 8.5 8.0 31.6 20.9 22.6 26.6 22.6 25.6 46.9 22.6 27.4 39.5 22.4 27.9 37.7 42.4 23.2 26.9 103.8 21.7 77.0 38.6 28.5 PNKD "BRP17, DKFZp564N1362, DYT8, FKSG19, FPD1, KIAA1184, KIPP1184, MGC31943, MR-1, MR-1S, PDC, PKND1, TAHCCP2" ENSG00000127838 "PNKD metallo-beta-lactamase domain containing" Q8N490 2 218270392-218346793 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" Hydrolase "Disease variant, Dystonia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal tubular cells: 508.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA010134, HPA017068" Approved Enhanced Mitochondria NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 35: Non-specific - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "HPA010134: AB_1079645, HPA017068: AB_1855495" "unprognostic (3.15e-3)" "unprognostic (1.80e-2)" "unprognostic (5.86e-3)" "unprognostic (1.89e-2)" "unprognostic (1.90e-1)" "unprognostic (1.60e-1)" "unprognostic (3.81e-2)" "unprognostic (1.54e-1)" "unprognostic (1.37e-1)" "unprognostic (7.51e-2)" "unprognostic (3.29e-1)" "unprognostic (7.67e-2)" "prognostic unfavorable (5.13e-5)" "unprognostic (7.98e-2)" "unprognostic (2.17e-1)" "unprognostic (9.61e-2)" "unprognostic (1.44e-3)" 50.9 88.9 127.6 33.3 134.7 35.4 49.7 131.2 168.4 62.8 129.3 74.7 40.6 45.6 77.3 40.5 60.6 41.6 98.4 127.8 137.5 106.5 191.5 55.5 40.9 133.9 130.9 47.1 46.1 93.4 49.5 46.9 134.1 87.4 54.7 26.7 60.6 55.3 85.1 44.9 51.1 36.4 128.7 58.7 81.6 45.6 137.8 45.8 90.0 93.6 37.6 64.2 45.4 134.7 53.2 68.3 49.1 77.0 72.2 60.6 90.0 32.7 70.3 76.1 85.0 112.9 51.2 61.7 63.7 55.0 83.5 53.6 95.4 61.4 52.9 128.0 119.4 90.0 119.5 169.4 78.7 58.9 38.6 83.0 59.8 51.9 15.0 51.0 83.2 48.0 67.8 78.3 68.4 152.2 77.6 139.5 49.0 121.3 69.3 75.1 49.5 51.8 88.3 79.2 47.4 39.9 23.6 156.9 94.6 52.0 52.4 56.4 51.5 31.4 53.7 37.5 45.5 32.4 35.7 69.0 79.9 95.8 38.8 142.4 111.4 151.9 97.7 114.3 94.2 223.1 105.7 117.7 106.4 187.2 116.4 111.2 31.3 136.2 109.4 99.0 150.0 132.2 127.6 134.7 131.2 168.4 127.8 137.5 133.9 130.9 134.1 128.7 137.8 134.7 84.5 70.5 91.2 30.0 58.2 55.2 91.5 179.2 82.6 54.5 130.1 162.4 154.5 128.7 127.8 196.8 6.2 172.9 48.2 292.0 508.7 70.6 13.5 125.9 116.5 66.9 121.3 56.3 44.9 49.8 105.3 88.5 99.9 114.1 57.1 97.0 83.2 250.4 136.7 35.3 47.4 186.3 187.2 85.3 59.6 16.5 103.2 66.2 136.9 20.6 79.6 168.8 51.5 19.6 32.8 37.7 143.6 124.1 74.6 93.4 162.7 326.7 148.5 41.6 92.1 60.0 128.6 42.5 50.6 113.9 62.4 77.3 52.5 97.2 228.1 117.5 PNKP PNK ENSG00000039650 "Polynucleotide kinase 3'-phosphatase" Q96T60 19 49859882-49878351 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair" "Hydrolase, Kinase, Multifunctional enzyme, Transferase" "Disease variant, Epilepsy, Mental retardation, Neurodegeneration, Primary microcephaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006782 Supported Supported Nucleoplasm,Nucleoli NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 18: Non-specific - Mitochondria" "Cluster 15: RT4 - Unknown function" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Nucleoli" "HPA006782: AB_1855496" "prognostic favorable (9.18e-4)" "unprognostic (1.87e-1)" "unprognostic (4.31e-2)" "unprognostic (4.23e-1)" "unprognostic (1.00e-1)" "unprognostic (4.40e-2)" "unprognostic (1.08e-2)" "unprognostic (1.24e-1)" "unprognostic (3.36e-1)" "unprognostic (1.58e-1)" "unprognostic (3.71e-2)" "unprognostic (1.70e-1)" "unprognostic (4.55e-2)" "unprognostic (3.00e-2)" "unprognostic (2.82e-1)" "unprognostic (7.24e-2)" "unprognostic (3.68e-3)" 18.9 45.1 12.0 21.0 12.9 26.4 21.2 12.8 16.2 21.1 24.2 21.6 16.0 21.3 13.5 19.4 22.9 10.6 23.9 14.4 11.9 27.3 22.4 22.2 17.5 14.0 14.0 23.7 28.6 16.7 36.8 11.1 14.3 25.3 13.1 10.1 21.6 12.4 18.5 17.8 22.8 11.5 12.8 37.2 25.0 21.2 13.3 12.3 31.9 7.8 15.3 19.4 18.0 14.1 27.5 17.4 19.1 27.2 15.8 13.4 28.6 43.4 21.2 18.7 17.7 17.5 34.2 18.4 13.6 13.6 11.3 23.5 6.1 25.9 10.9 22.3 27.2 30.0 36.7 14.8 12.2 25.8 36.3 13.2 13.0 17.9 11.0 16.9 26.3 23.4 14.9 34.3 24.7 18.8 28.7 23.5 16.0 28.3 37.4 24.3 15.9 34.7 21.0 68.5 20.6 33.4 19.3 52.5 9.2 14.5 10.2 14.8 36.0 37.6 24.9 9.6 35.8 38.7 16.5 13.0 33.8 12.3 30.8 1.8 12.3 16.7 9.2 11.5 7.9 9.1 7.8 7.3 9.8 12.2 5.7 5.0 23.4 3.9 18.1 5.5 9.1 5.8 12.0 12.9 12.8 16.2 14.4 11.9 14.0 14.0 14.3 12.8 13.3 14.1 23.6 16.0 23.6 5.9 47.2 13.4 35.4 29.9 25.6 40.9 28.1 23.7 11.1 21.5 19.1 20.2 81.3 44.5 37.7 40.0 23.5 42.5 15.0 25.2 28.5 26.6 30.5 17.1 6.0 39.9 35.1 19.1 31.6 28.0 29.1 54.6 35.0 20.1 39.5 33.7 6.0 31.7 24.4 27.7 19.0 32.9 59.4 26.8 14.2 8.4 46.1 18.4 96.8 6.0 5.7 44.6 22.3 44.8 40.4 33.6 27.1 36.1 33.8 73.9 19.7 17.9 20.1 19.4 28.9 23.3 13.1 49.3 39.2 83.0 34.1 35.6 PNPLA6 "iPLA2delta, NTE, SPG39, sws" ENSG00000032444 "Patatin like phospholipase domain containing 6" Q8IY17 19 7534004-7561764 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Lipid degradation, Lipid metabolism" Hydrolase "Disease variant, Dwarfism, Hereditary spastic paraplegia, Hypogonadotropic hypogonadism, Mental retardation, Neurodegeneration, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 73.4;Late spermatids: 106.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007522, HPA064773" Uncertain Approved "Endoplasmic reticulum,Cytosol" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 43: Testis - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 45: Enterocytes - Digestion" "Endoplasmic reticulum, Cytosol" "HPA007522: AB_1079649, HPA064773: " "unprognostic (2.73e-1)" "unprognostic (1.02e-1)" "unprognostic (1.52e-1)" "unprognostic (3.23e-2)" "unprognostic (2.78e-1)" "prognostic favorable (5.25e-4)" "unprognostic (3.53e-3)" "unprognostic (1.50e-1)" "unprognostic (2.07e-2)" "unprognostic (1.62e-1)" "prognostic favorable (3.51e-5)" "unprognostic (3.36e-1)" "prognostic favorable (7.53e-4)" "unprognostic (3.10e-3)" "unprognostic (3.50e-1)" "unprognostic (3.25e-1)" "unprognostic (2.17e-1)" 17.9 27.3 18.3 26.2 23.2 26.1 16.4 14.7 31.5 20.2 12.6 25.7 26.9 20.8 5.3 20.4 16.8 13.7 20.7 21.9 16.3 25.6 21.9 40.4 19.5 23.4 20.3 18.8 16.4 15.6 32.7 13.6 25.6 21.4 8.4 10.6 15.8 12.8 33.5 17.5 29.6 14.5 10.1 41.9 19.2 36.4 23.7 10.9 22.7 19.5 8.9 24.6 17.4 23.6 32.4 80.1 14.7 36.1 25.5 37.0 34.3 42.2 41.9 31.4 28.8 18.6 43.7 27.3 69.1 55.3 19.7 40.8 13.1 39.4 16.3 68.5 29.2 17.7 41.8 13.9 29.2 20.2 53.0 31.6 22.2 41.8 23.8 49.2 62.7 31.4 14.9 36.5 28.6 15.7 22.2 26.0 16.2 15.5 71.7 17.3 9.0 31.9 27.9 31.2 19.0 32.5 34.9 15.7 45.6 20.4 14.1 27.6 67.0 38.5 22.1 53.3 44.2 42.6 30.1 12.2 64.2 23.2 36.7 15.7 11.3 37.6 5.4 20.0 5.5 6.5 3.8 5.7 12.1 4.3 3.3 4.5 3.2 7.9 35.0 3.8 6.9 8.8 18.3 23.2 14.7 31.5 21.9 16.3 23.4 20.3 25.6 10.1 23.7 23.6 12.6 6.4 12.0 16.6 11.9 4.8 4.1 9.3 8.6 12.1 10.9 8.3 10.0 15.7 10.1 33.1 27.1 18.2 14.4 48.5 1.9 15.8 73.4 8.2 7.2 13.5 17.4 25.4 14.0 7.1 15.5 7.3 14.8 10.7 12.0 19.5 13.6 20.2 27.4 21.9 16.1 14.6 10.2 68.3 16.0 106.1 9.6 42.4 8.8 15.0 23.6 9.2 21.6 9.0 16.4 9.5 17.9 7.5 8.8 4.9 67.0 12.1 14.4 16.5 0.0 7.1 7.7 60.8 10.5 8.5 5.5 12.4 15.9 10.0 20.9 3.6 PNPO PDXPO ENSG00000108439 "Pyridoxamine 5'-phosphate oxidase" Q9NVS9 17 47941506-47949308 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Pyridoxine biosynthesis" Oxidoreductase "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 88.8" "Cell type enhanced" "Detected in many" "Distal tubular cells: 62.6;Hepatocytes: 53.4;Proximal tubular cells: 86.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023204, HPA027776" Enhanced Approved Nucleoplasm,Cytosol NA NA 450000 "Cluster 39: Non-specific - mRNA processing" "Cluster 15: Liver - Metabolism" "Cluster 39: CACO-2 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nucleoplasm, Cytosol" "HPA023204: AB_1855506, HPA027776: AB_10601246" "unprognostic (1.88e-2)" "unprognostic (1.17e-1)" "unprognostic (1.17e-1)" "unprognostic (1.07e-1)" "unprognostic (9.25e-2)" "unprognostic (2.39e-2)" "unprognostic (1.23e-2)" "unprognostic (1.41e-1)" "unprognostic (2.62e-1)" "unprognostic (1.97e-2)" "unprognostic (6.65e-2)" "unprognostic (8.34e-2)" "unprognostic (2.02e-3)" "unprognostic (7.47e-3)" "unprognostic (8.75e-2)" "unprognostic (3.34e-2)" "unprognostic (2.74e-1)" 7.3 15.8 16.5 6.2 15.9 3.5 10.6 16.7 22.0 7.0 12.9 8.8 10.2 5.0 11.6 10.7 10.1 6.6 13.2 16.0 21.9 35.1 88.8 6.4 6.9 19.1 21.2 5.8 10.9 26.6 9.2 7.0 20.6 8.0 8.6 5.4 10.4 7.8 21.1 6.7 9.6 6.1 16.5 7.2 8.6 6.6 20.6 5.8 17.8 19.6 7.7 6.7 7.3 14.3 37.9 30.9 2.4 5.8 15.3 11.7 0.0 12.2 7.7 14.0 11.9 51.1 27.6 35.2 57.4 12.7 5.5 22.0 19.4 34.7 20.3 43.4 16.4 24.6 13.9 53.6 16.3 22.6 16.6 15.4 26.9 25.8 32.7 13.1 18.0 26.1 24.4 12.2 16.5 28.3 25.3 7.8 4.5 37.4 37.1 18.8 10.4 26.2 40.2 19.5 12.1 9.5 11.2 18.6 10.7 8.5 32.4 9.1 19.1 22.6 12.8 22.2 26.2 27.8 34.0 19.0 18.4 19.2 11.7 2.5 12.3 2.8 7.2 17.7 8.2 6.7 6.3 7.6 13.5 5.3 8.2 8.1 1.1 7.9 11.9 9.8 7.0 10.3 16.5 15.9 16.7 22.0 16.0 21.9 19.1 21.2 20.6 16.5 20.6 14.3 7.6 12.8 13.9 7.5 3.9 1.5 6.7 5.0 5.7 1.1 16.2 14.4 1.9 18.6 6.8 12.9 4.2 8.4 7.8 7.3 62.6 18.2 0.8 11.2 6.4 5.9 3.6 7.4 4.2 15.6 1.9 5.3 4.6 13.3 12.7 8.8 6.4 53.4 17.2 3.3 6.2 11.6 2.0 11.4 2.4 0.9 9.9 10.6 1.8 2.8 8.6 7.1 3.1 2.5 3.2 15.0 8.9 6.0 4.9 9.0 20.2 86.3 5.9 1.9 0.0 4.1 3.8 0.7 1.3 7.2 2.3 6.3 4.7 19.5 15.4 5.0 POC1B "FLJ14923, TUWD12, WDR51B" ENSG00000139323 "POC1 centriolar protein B" Q8TC44 12 89419718-89526047 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cilium biogenesis/degradation" "Cone-rod dystrophy, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Glandular and luminal cells: 73.2;Late spermatids: 96.3;Oligodendrocytes: 99.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 45: Intestine - Brush border" "Cluster 6: T47d - Mammary gland" "Cluster 44: Endometrium - Transcription" "unprognostic (1.06e-2)" "unprognostic (1.32e-1)" "unprognostic (1.28e-2)" "prognostic favorable (9.59e-5)" "unprognostic (4.86e-3)" "unprognostic (6.81e-2)" "unprognostic (1.07e-1)" "unprognostic (1.34e-1)" "unprognostic (6.18e-3)" "unprognostic (1.12e-1)" "unprognostic (3.68e-2)" "unprognostic (2.05e-2)" "prognostic favorable (3.45e-6)" "unprognostic (3.10e-2)" "unprognostic (1.94e-1)" "unprognostic (1.89e-1)" "unprognostic (8.69e-2)" 6.0 5.6 8.1 6.3 10.8 6.5 8.0 9.7 11.2 11.4 6.0 12.6 11.9 8.7 4.9 5.9 12.3 8.4 5.8 7.5 9.1 11.9 8.0 6.6 7.9 10.3 9.4 7.3 4.8 9.3 5.2 7.0 10.1 5.3 12.8 5.4 8.0 6.3 4.9 4.3 12.7 6.3 9.9 8.9 10.9 7.2 8.9 7.6 8.1 7.2 8.0 8.4 5.9 14.1 13.4 12.0 12.2 21.6 12.3 9.6 8.5 13.3 12.7 10.5 9.4 7.1 6.1 5.3 3.5 9.2 11.2 10.2 10.6 15.4 16.1 17.9 9.2 11.3 4.0 9.2 7.2 17.5 13.1 6.4 10.7 13.3 21.9 25.6 21.7 19.6 11.9 10.9 13.5 8.9 13.2 17.0 5.9 25.1 30.8 15.3 12.9 15.1 17.0 16.1 11.2 12.1 10.3 15.7 18.9 14.7 24.6 8.0 12.9 9.0 3.1 12.7 10.8 13.7 12.1 12.5 7.5 14.6 10.1 12.1 9.8 14.8 15.0 10.0 19.2 9.4 10.6 13.2 8.9 10.4 8.5 11.6 10.3 18.9 9.4 2.3 10.6 11.1 8.1 10.8 9.7 11.2 7.5 9.1 10.3 9.4 10.1 9.9 8.9 14.1 8.6 9.6 9.4 30.7 15.5 9.1 9.1 9.5 4.6 6.8 8.6 4.6 8.2 17.2 18.6 3.7 31.3 5.8 19.1 12.0 15.6 9.2 60.5 53.1 11.4 10.0 10.2 22.3 39.4 12.5 3.6 8.3 18.8 73.2 17.7 9.7 8.2 6.8 7.2 5.0 25.0 13.9 10.2 14.1 17.7 96.3 7.2 14.2 10.6 15.9 11.2 6.9 18.6 30.7 99.1 9.2 14.8 8.2 15.1 13.0 15.3 19.4 30.3 41.1 0.0 6.3 8.0 14.6 2.6 10.7 11.9 5.6 20.1 6.2 14.2 22.2 POLG "POLG1, POLGA" ENSG00000140521 "DNA polymerase gamma, catalytic subunit" P54098 15 89305198-89334861 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA replication" "DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase" "Disease variant, Epilepsy, Leigh syndrome, Neurodegeneration, Neuropathy, Primary mitochondrial disease, Progressive external ophthalmoplegia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA056821, HPA078482" Approved Supported Mitochondria NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 72: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 65: Plasmacytoid DCs - Unknown function" Mitochondria "HPA056821: AB_2683247, HPA078482: " "unprognostic (1.87e-1)" "unprognostic (4.71e-2)" "unprognostic (2.61e-2)" "unprognostic (3.64e-1)" "unprognostic (1.62e-1)" "unprognostic (3.19e-1)" "unprognostic (2.22e-1)" "unprognostic (1.13e-1)" "unprognostic (8.41e-2)" "unprognostic (2.63e-1)" "unprognostic (1.41e-1)" "prognostic unfavorable (5.73e-4)" "unprognostic (2.65e-3)" "unprognostic (1.58e-2)" "unprognostic (4.29e-2)" "unprognostic (2.07e-1)" "unprognostic (3.45e-1)" 13.3 11.1 6.8 4.0 5.0 2.6 12.0 4.8 6.3 12.0 4.5 13.3 5.5 12.9 0.4 14.6 11.2 0.9 13.8 6.1 3.5 10.1 12.9 13.8 3.0 9.0 5.8 10.8 10.7 2.9 8.4 2.5 6.5 10.5 0.9 1.4 12.3 2.2 25.0 16.0 14.5 1.3 5.4 16.2 11.9 5.4 5.7 7.3 10.5 10.9 2.4 12.2 12.7 6.3 8.0 17.0 6.7 10.0 7.7 1.6 16.4 16.4 2.7 7.9 5.9 28.0 10.9 14.4 33.6 5.9 16.9 11.8 14.3 4.8 0.9 35.8 31.3 19.4 19.5 11.1 10.8 21.3 33.6 2.4 8.7 7.0 3.0 8.3 12.2 26.8 19.5 5.4 6.1 22.8 16.3 16.5 8.7 13.7 8.2 18.2 13.7 17.4 3.2 19.2 24.5 6.9 26.8 9.6 16.8 6.0 7.7 10.8 17.3 12.8 15.6 28.5 14.2 17.0 9.4 18.6 9.5 14.3 11.6 3.3 4.3 6.1 5.5 4.0 4.3 2.0 4.6 6.8 6.0 3.0 3.7 4.4 1.8 5.0 3.5 4.1 3.3 5.3 6.8 5.0 4.8 6.3 6.1 3.5 9.0 5.8 6.5 5.4 5.7 6.3 15.7 12.8 11.9 11.4 17.2 12.2 11.0 10.7 9.1 7.6 12.0 10.3 19.0 11.5 9.5 11.0 2.1 15.0 33.8 17.2 9.8 10.4 1.3 8.4 9.4 12.4 5.4 9.0 12.9 10.9 15.8 11.9 21.4 11.3 8.2 14.8 14.6 17.8 12.7 3.3 9.9 24.9 4.1 18.5 14.7 1.5 14.3 17.2 19.6 8.4 21.8 6.1 30.9 9.5 11.9 11.4 15.9 10.5 16.8 17.7 10.5 7.5 7.8 6.4 6.6 13.3 12.9 9.2 11.1 11.8 11.9 21.8 21.7 14.8 17.6 15.5 POLG2 "HP55, MTPOLB" ENSG00000256525 "DNA polymerase gamma 2, accessory subunit" Q9UHN1 17 64477785-64497054 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "DNA replication" DNA-binding "Disease variant, Primary mitochondrial disease, Progressive external ophthalmoplegia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Skeletal myocytes: 92.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected" "Not detected" "CAB017030, HPA023202, HPA078396" Approved Supported "Nuclear bodies,Mitochondria" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 71: Testis - DNA repair" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 7: Non-specific - Mitochondria" Mitochondria "Nuclear bodies" "CAB017030: , HPA023202: AB_1855523, HPA078396: " "unprognostic (1.76e-1)" "unprognostic (2.20e-1)" "unprognostic (1.59e-1)" "unprognostic (7.02e-2)" "unprognostic (6.01e-2)" "unprognostic (2.91e-2)" "prognostic unfavorable (1.39e-6)" "unprognostic (4.38e-2)" "unprognostic (8.46e-2)" "unprognostic (3.14e-1)" "unprognostic (5.17e-3)" "prognostic unfavorable (6.59e-4)" "prognostic unfavorable (1.17e-5)" "unprognostic (5.17e-2)" "unprognostic (1.58e-1)" "unprognostic (2.88e-2)" "unprognostic (4.82e-2)" 4.5 5.8 2.7 4.4 3.0 3.6 4.5 3.9 4.5 6.8 3.0 4.7 3.5 4.7 2.0 4.0 5.6 2.4 5.0 2.8 3.6 5.7 5.3 3.9 5.4 3.2 3.0 7.9 4.7 2.4 4.0 2.9 3.1 5.1 1.9 2.6 3.9 2.9 6.8 4.2 5.6 2.0 2.9 7.5 4.0 12.8 3.1 6.3 5.8 4.2 4.0 4.8 5.3 3.9 8.1 10.4 6.7 7.6 7.2 4.7 8.4 4.6 4.6 7.0 5.9 10.1 6.2 15.7 5.4 2.8 6.5 5.3 9.3 3.9 8.8 4.6 11.0 9.9 12.2 10.5 7.0 14.2 10.6 4.5 4.7 5.3 7.2 8.4 4.7 7.6 18.3 4.7 6.5 10.0 15.3 15.4 7.3 8.6 11.2 13.3 23.8 14.2 6.4 2.4 9.3 10.0 4.4 7.1 8.0 8.7 7.4 12.0 6.1 7.0 9.9 5.8 12.3 8.4 7.2 11.3 5.9 13.4 4.8 7.2 5.2 6.0 6.5 3.2 6.6 10.7 7.5 6.2 9.7 11.9 9.7 9.7 0.9 5.8 8.4 4.4 8.1 4.0 2.7 3.0 3.9 4.5 2.8 3.6 3.2 3.0 3.1 2.9 3.1 3.9 24.6 12.8 21.2 7.8 19.6 8.2 13.7 7.8 16.5 5.0 30.1 37.5 18.4 12.8 13.3 3.7 0.0 13.0 22.7 31.7 0.0 5.4 14.7 16.5 26.7 16.0 10.9 20.4 9.1 3.8 14.4 19.2 14.8 29.2 13.3 9.9 14.6 4.7 9.2 6.7 7.4 13.9 6.1 6.9 7.1 7.3 6.5 17.7 7.2 11.2 8.0 4.5 18.6 13.0 14.1 2.9 21.8 3.0 6.3 9.8 8.9 5.2 7.1 9.2 6.6 92.0 18.4 49.7 9.2 10.8 8.7 4.0 16.2 15.2 19.8 5.2 POMGNT1 "FLJ20277, LGMD2O, MEB, MGAT1.2" ENSG00000085998 "Protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)" Q8WZA1 1 46188682-46220305 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Congenital muscular dystrophy, Disease variant, Dystroglycanopathy, Limb-girdle muscular dystrophy, Lissencephaly, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044518 Approved NA NA 17000000 "Cluster 15: NK-cells - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 22: Epithelial cell types - Mixed function" "HPA044518: AB_10795985" "unprognostic (4.59e-3)" "unprognostic (1.59e-1)" "unprognostic (2.13e-1)" "unprognostic (1.80e-1)" "unprognostic (2.24e-1)" "unprognostic (3.20e-1)" "prognostic unfavorable (3.52e-4)" "unprognostic (1.82e-1)" "unprognostic (5.74e-2)" "unprognostic (5.37e-2)" "prognostic favorable (4.27e-4)" "unprognostic (5.86e-2)" "unprognostic (4.39e-2)" "unprognostic (4.99e-3)" "unprognostic (1.72e-1)" "unprognostic (2.16e-2)" "unprognostic (2.36e-1)" 22.5 40.4 45.8 14.9 51.9 5.5 23.7 52.7 50.4 26.3 44.5 23.9 21.5 24.1 31.1 18.7 26.2 17.8 83.3 45.9 49.8 36.5 40.7 24.0 13.6 55.0 53.3 21.9 29.5 87.5 47.3 20.8 53.8 37.9 17.9 21.8 24.8 27.5 73.9 23.2 19.6 27.8 51.2 24.6 30.3 37.2 50.9 18.8 37.9 48.1 16.2 27.8 21.0 61.0 37.7 39.6 47.3 46.0 51.0 55.3 60.9 49.3 82.7 65.9 51.5 22.6 30.5 34.6 79.7 82.3 112.3 21.1 34.2 70.5 39.3 45.4 38.6 27.3 34.2 34.3 44.6 21.3 25.8 56.2 90.5 73.7 68.2 118.0 68.0 46.6 32.9 21.9 108.9 26.2 37.8 15.3 39.2 21.5 54.7 27.2 48.4 32.7 58.2 45.9 17.9 64.1 45.7 52.1 70.7 67.4 34.8 29.8 50.0 49.2 43.5 56.4 96.4 54.7 65.3 16.1 75.1 20.8 53.5 0.0 1.1 1.2 3.3 2.1 2.2 1.4 2.2 2.6 1.6 2.6 4.1 3.2 0.0 6.2 4.1 4.6 2.5 1.4 45.8 51.9 52.7 50.4 45.9 49.8 55.0 53.3 53.8 51.2 50.9 61.0 12.0 12.8 40.4 15.0 11.7 8.4 40.4 31.0 13.6 38.9 18.5 14.9 44.5 21.5 30.1 35.0 50.1 25.2 17.5 13.9 13.7 39.3 47.6 15.3 13.7 17.5 27.0 9.0 19.4 39.9 27.4 14.8 7.1 27.1 27.1 25.2 14.6 20.5 15.6 26.9 20.6 12.6 16.2 14.6 6.4 15.6 20.2 10.6 24.9 8.4 18.0 21.9 19.6 19.6 33.7 38.7 14.5 13.2 16.9 44.4 19.0 22.8 21.2 36.4 13.1 16.4 16.4 11.2 12.9 12.7 7.5 23.4 13.6 19.0 17.4 33.0 PON1 "ESA, PON" ENSG00000005421 "Paraoxonase 1" P27169 7 95297676-95324532 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted secreted proteins, Transporters" Hydrolase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 103 "liver: 531.8" "Cell type enriched" "Detected in some" 23 "Hepatocytes: 440.0" "Cancer enriched" "Detected in some" 78 "liver cancer: 97.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA001610 Approved "Secreted to blood" NA NA 96000000000 17000000000 "Cluster 62: Liver - Hemostasis" "Cluster 2: Hepatocytes - Metabolism" "HPA001610: AB_1079656" "unprognostic (2.02e-2)" "unprognostic (2.41e-2)" "unprognostic (3.04e-1)" "unprognostic (3.54e-2)" "unprognostic (2.70e-1)" "prognostic favorable (7.24e-7)" "unprognostic (2.24e-1)" "unprognostic (1.95e-1)" "unprognostic (9.02e-3)" "unprognostic (1.76e-3)" "unprognostic (3.97e-2)" "unprognostic (6.74e-9)" "unprognostic (1.09e-3)" "unprognostic (2.29e-2)" "unprognostic (2.07e-1)" "unprognostic (5.54e-3)" 0.0 4.1 0.6 0.0 0.5 0.0 0.1 0.6 0.6 0.2 0.2 0.1 0.0 0.0 0.0 0.0 0.1 1.1 0.0 0.5 0.6 0.2 531.8 0.1 0.0 0.5 0.5 0.6 0.1 0.0 0.8 0.0 0.5 0.3 0.0 0.1 0.1 0.0 0.0 0.1 0.1 0.0 0.3 0.0 0.0 0.3 0.6 5.1 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.6 0.5 0.6 0.6 0.5 0.6 0.5 0.5 0.5 0.3 0.6 0.6 0.0 0.0 1.5 7.2 1.1 0.0 0.0 0.0 0.0 0.6 0.2 0.3 0.6 18.6 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.4 3.0 13.5 0.2 0.2 0.0 0.2 0.0 0.3 0.0 0.1 8.9 440.0 0.0 0.0 0.2 0.2 0.0 13.4 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.3 0.0 2.0 0.2 0.1 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.4 0.0 1.6 0.5 0.4 0.2 0.0 0.1 0.0 0.6 0.5 0.3 0.1 POU3F4 "BRN4, DFN3, DFNX2, OTF9" ENSG00000196767 "POU class 3 homeobox 4" X 83508290-83512127 "Human disease related genes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "brain: 11.9" "Cell type enriched" "Detected in some" 6 "Collecting duct cells: 11.0" "Cancer enriched" "Detected in single" 21 "glioma: 5.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 99 "AF22: 9.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA062295 Supported Nucleoplasm NA NA "Cluster 65: Brain - Ion transport" "Cluster 12: NES - Nervous system development" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA062295: AB_2732681" "unprognostic (5.73e-2)" "unprognostic (2.00e-1)" 0.0 0.0 2.3 0.0 11.9 0.0 0.0 2.6 4.5 0.0 0.6 0.4 0.0 0.0 0.0 0.0 0.0 0.2 0.0 1.5 2.5 1.6 0.0 0.0 0.0 2.9 5.5 0.1 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 9.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 11.9 2.6 4.5 1.5 2.5 2.9 5.5 2.5 2.6 3.4 1.6 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 11.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 POU4F3 "BRN3C, DFNA15, DFNA42, DFNA52" ENSG00000091010 "POU class 4 homeobox 3" Q15319 5 146338839-146341728 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Differentiation, Transcription, Transcription regulation" "Activator, DNA-binding" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in single" "urothelial cancer: 0.6" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA038215 Uncertain Supported Nucleoplasm NA NA Nucleoplasm "HPA038215: AB_10697245" "unprognostic (8.41e-3)" "unprognostic (9.46e-2)" "unprognostic (1.84e-1)" "unprognostic (6.26e-4)" "unprognostic (1.86e-1)" "unprognostic (1.12e-1)" "unprognostic (1.03e-1)" "unprognostic (9.54e-2)" "unprognostic (1.61e-1)" "unprognostic (2.09e-3)" "unprognostic (1.20e-3)" "unprognostic (1.24e-3)" "unprognostic (1.38e-1)" "unprognostic (1.87e-1)" "unprognostic (8.84e-2)" "unprognostic (7.82e-2)" 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.5 0.1 0.1 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PPIP5K2 "CFAP160, DFNB100, HISPPD1, KIAA0433, VIP2" ENSG00000145725 "Diphosphoinositol pentakisphosphate kinase 2" O43314 5 103120149-103212799 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Hearing "Kinase, Transferase" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Inhibitory neurons: 160.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037895, HPA038442" Approved Approved Vesicles NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 34: Non-specific - Transcription" "Cluster 32: U-937 - Innate immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles "HPA037895: AB_2675724, HPA038442: AB_10673173" "unprognostic (2.18e-1)" "unprognostic (1.04e-1)" "unprognostic (2.36e-2)" "unprognostic (1.93e-1)" "unprognostic (8.83e-2)" "unprognostic (1.60e-3)" "unprognostic (1.13e-1)" "unprognostic (2.43e-1)" "unprognostic (1.60e-2)" "unprognostic (8.59e-3)" "unprognostic (1.39e-1)" "unprognostic (2.12e-1)" "unprognostic (4.32e-2)" "unprognostic (1.29e-1)" "unprognostic (4.06e-1)" "prognostic unfavorable (1.12e-4)" "unprognostic (8.80e-2)" 15.7 19.1 6.8 22.0 7.9 51.6 25.1 18.9 13.9 22.2 5.8 28.1 18.3 20.6 21.2 17.1 14.5 20.4 19.5 6.7 8.9 20.3 29.2 16.2 25.5 15.4 11.9 26.1 26.7 23.0 18.1 16.7 15.1 16.3 25.5 19.2 17.1 15.4 4.2 17.2 16.5 18.4 6.1 23.9 22.5 15.1 7.3 27.9 23.3 7.7 24.5 17.8 13.9 10.7 27.4 25.3 50.8 65.2 40.8 53.4 47.8 63.5 39.3 34.2 47.6 20.9 48.3 67.6 56.2 60.9 52.7 16.5 43.9 33.2 57.5 53.7 23.5 84.7 44.3 33.4 29.0 72.1 70.4 34.5 23.4 52.0 46.1 31.2 40.0 42.5 84.9 57.0 53.1 21.3 60.9 44.6 55.4 12.7 64.4 58.6 46.7 89.3 36.8 31.5 29.6 40.1 43.5 39.9 40.7 34.0 33.5 48.9 42.7 55.8 25.7 56.0 45.1 38.1 87.3 91.3 31.5 116.0 51.2 41.7 21.5 39.6 13.0 22.9 15.8 19.5 12.6 14.2 25.6 16.1 16.1 17.0 19.7 17.8 32.4 15.5 12.3 11.1 6.8 7.9 18.9 13.9 6.7 8.9 15.4 11.9 15.1 6.1 7.3 10.7 35.8 48.1 23.1 49.3 39.3 13.6 12.8 13.7 31.9 38.5 26.1 26.4 48.9 18.6 29.6 16.5 45.9 12.7 35.7 29.7 5.9 11.6 5.6 25.4 44.7 28.7 16.3 70.7 88.4 17.0 19.2 33.0 33.6 30.6 43.6 49.2 14.6 20.6 30.6 16.8 160.3 24.2 16.2 39.5 22.4 6.7 29.5 43.3 12.4 49.6 47.5 14.5 27.8 62.8 67.0 16.9 19.1 23.7 56.6 12.1 13.3 22.6 25.1 25.2 6.6 30.3 28.1 39.7 21.6 31.6 15.8 26.0 31.6 38.7 30.1 12.6 PPP2R2B "B55beta, PR52B, PR55-BETA, SCA12" ENSG00000156475 "Protein phosphatase 2 regulatory subunit Bbeta" Q00005 5 146580742-147084784 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" Apoptosis "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 77.1;retina: 43.0" "Cell type enhanced" "Detected in many" "Astrocytes: 1539.0;Excitatory neurons: 846.0;Inhibitory neurons: 788.8;Late spermatids: 876.4;Oligodendrocyte precursor cells: 1035.4;Oligodendrocytes: 4480.1" "Cancer enriched" "Detected in some" 8 "glioma: 7.1" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 6 "gdT-cell: 5.2;MAIT T-cell: 4.1;memory CD4 T-cell: 2.4;memory CD8 T-cell: 6.2;naive CD8 T-cell: 3.8;NK-cell: 2.9;T-reg: 3.4" "Group enriched" "Detected in many" 9 "NK-cells: 2.9;T-cells: 6.2" "Cell line enhanced" "Detected in some" "HaCaT: 7.2;HDLM-2: 24.2;RT4: 12.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038118, HPA042122, HPA042770" Approved Uncertain Cytosol NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 58: Brain - Synaptic function" "Cluster 44: HDLM-2 - Immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "HPA038118: AB_10697238, HPA042122: AB_2677859, HPA042770: AB_2678155" "unprognostic (4.54e-5)" "unprognostic (1.74e-1)" "unprognostic (1.21e-1)" "unprognostic (2.80e-4)" "unprognostic (2.48e-1)" "unprognostic (1.44e-1)" "unprognostic (2.76e-1)" "unprognostic (1.84e-2)" "unprognostic (2.68e-1)" "unprognostic (3.20e-2)" "unprognostic (9.73e-4)" "unprognostic (4.51e-2)" "unprognostic (1.49e-8)" "unprognostic (2.02e-1)" "unprognostic (3.67e-1)" "unprognostic (5.48e-5)" "unprognostic (1.14e-4)" 1.3 7.8 53.9 0.9 71.4 1.9 0.8 44.7 77.1 1.2 6.0 6.5 1.0 0.4 0.5 1.3 3.6 1.8 2.5 57.8 53.9 3.7 0.7 0.8 1.7 50.7 56.3 0.4 1.9 2.8 14.8 0.7 50.4 1.9 1.9 43.0 1.0 1.0 0.3 3.4 2.2 1.3 50.7 1.8 1.1 18.9 71.6 0.8 3.1 0.3 0.8 7.5 2.0 73.9 0.2 0.0 1.3 2.0 0.2 0.0 0.4 0.7 0.3 0.7 0.2 2.3 1.9 0.2 0.2 0.1 0.0 7.2 0.5 0.4 1.8 24.2 0.4 0.4 4.8 0.6 0.4 0.1 0.4 0.2 1.2 0.0 0.4 0.8 0.3 0.7 0.7 0.5 0.9 0.3 0.2 0.1 2.3 0.0 0.9 1.6 0.2 0.0 1.9 12.5 1.3 0.2 0.3 0.0 0.3 1.4 0.7 0.0 0.4 0.1 0.3 1.7 0.6 0.1 0.4 0.2 0.9 1.9 2.0 0.5 0.0 0.0 5.2 0.0 4.1 0.1 2.4 6.2 0.0 0.0 0.6 3.8 0.1 2.9 0.1 0.0 3.4 1.4 53.9 71.4 44.7 77.1 57.8 53.9 50.7 56.3 50.4 50.7 71.6 73.9 0.5 3.2 1.8 1539.0 0.3 2.0 1.1 2.3 4.6 90.5 0.5 3.6 1.6 10.0 0.9 9.2 150.1 18.9 30.2 0.0 21.5 1.7 295.3 1.0 0.1 2.0 13.1 1.3 846.0 0.0 0.3 1.1 1.1 0.4 0.0 0.0 0.0 0.0 0.9 47.1 788.8 0.0 0.0 1.2 4.7 876.4 3.4 1.4 5.4 58.1 0.3 45.0 57.7 1035.4 4480.1 0.6 0.0 2.2 3.3 1.0 0.0 5.5 0.1 275.4 0.0 0.7 11.0 4.8 2.2 1.6 1.4 5.3 31.0 0.1 0.0 0.9 PPP3CA "CALN, CALNA, CNA1, PPP2B" ENSG00000138814 "Protein phosphatase 3 catalytic subunit alpha" Q08209 4 101023409-101348278 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Calmodulin-binding, Hydrolase, Protein phosphatase" "Craniosynostosis, Disease variant, Dwarfism, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 144.1" "Cell type enhanced" "Detected in all" "Excitatory neurons: 933.8;Inhibitory neurons: 403.0;Oligodendrocyte precursor cells: 348.3" "Cancer enriched" "Detected in all" 7 "prostate cancer: 98.1" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012778, CAB018581" Enhanced Enhanced Nucleoplasm,Cytosol NA NA 94000 "Cluster 49: Eosinophils - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm Cytosol "CAB018581: AB_2168324, HPA012778: AB_1855660" "unprognostic (6.66e-2)" "unprognostic (1.96e-1)" "unprognostic (3.40e-1)" "unprognostic (1.36e-1)" "unprognostic (1.56e-1)" "unprognostic (7.81e-2)" "unprognostic (1.77e-2)" "unprognostic (1.08e-1)" "unprognostic (7.87e-2)" "unprognostic (3.49e-3)" "prognostic unfavorable (3.82e-4)" "unprognostic (3.38e-2)" "unprognostic (2.51e-2)" "unprognostic (5.12e-2)" "unprognostic (1.98e-1)" "unprognostic (1.84e-2)" "unprognostic (5.74e-2)" 24.7 17.5 48.5 15.7 144.1 17.2 20.5 63.2 125.6 17.0 0.0 19.5 11.6 11.8 13.1 14.4 13.8 13.3 9.2 97.4 25.0 11.2 17.0 19.9 14.7 14.6 11.0 17.9 9.4 8.9 9.0 13.0 15.7 66.0 16.1 27.6 22.2 38.4 51.2 22.9 12.9 15.5 24.7 14.5 22.4 10.6 23.9 12.8 13.2 29.0 18.3 20.7 16.0 54.3 48.3 33.8 9.3 18.0 50.4 37.9 15.8 51.9 47.8 19.8 21.6 18.3 59.0 22.4 20.9 47.6 25.6 23.5 33.3 69.6 34.9 56.0 15.1 35.4 45.8 25.2 36.8 59.0 17.8 39.6 35.6 45.3 51.4 39.1 38.8 14.5 14.4 61.1 33.5 58.0 12.2 44.2 15.4 55.7 20.7 22.1 83.2 26.5 20.0 38.3 71.5 26.2 43.1 35.4 24.6 12.5 32.3 33.4 42.1 48.7 54.8 44.7 34.7 28.5 31.5 40.1 26.6 31.5 13.1 82.5 31.0 73.5 35.7 33.1 41.6 74.1 33.2 34.8 28.2 62.8 15.5 31.0 123.7 65.1 45.1 51.9 25.3 21.1 48.5 144.1 63.2 125.6 97.4 25.0 14.6 11.0 15.7 24.7 23.9 54.3 143.3 76.9 58.6 284.1 96.8 168.8 36.2 29.5 34.7 89.8 93.8 51.8 25.0 38.6 21.9 31.3 39.6 39.6 81.4 60.0 33.2 21.3 3.2 39.3 56.2 100.8 127.4 32.0 933.8 31.6 84.0 75.6 59.1 42.8 35.4 22.1 53.2 39.7 38.3 18.5 403.0 44.2 14.2 61.8 135.3 8.4 65.0 58.2 92.5 281.1 64.3 21.2 56.7 348.3 139.1 53.3 115.4 60.9 63.8 127.6 23.9 51.9 25.3 82.9 13.1 66.9 67.5 12.7 26.5 27.9 172.0 27.5 69.1 76.2 55.9 39.5 PRCD RP36 ENSG00000214140 "Photoreceptor disc component" Q00LT1 17 76527586-76553578 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Sensory transduction, Vision" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 17 "retina: 48.0" "Cell type enhanced" "Detected in many" "Bipolar cells: 134.3;Cone photoreceptor cells: 152.2;Muller glia cells: 100.4;Rod photoreceptor cells: 551.3" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 1.6;Hep G2: 2.1;HSkMC: 1.1;SH-SY5Y: 2.4" "Low region specificity" "Detected in many" "Intracellular and membrane" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 46: Photoreceptor cells - Phototransduction" "unprognostic (2.37e-2)" "unprognostic (1.50e-1)" "unprognostic (3.50e-2)" "unprognostic (1.83e-3)" "unprognostic (3.74e-1)" "unprognostic (1.31e-4)" "unprognostic (6.56e-2)" "unprognostic (4.07e-3)" "unprognostic (1.76e-1)" "unprognostic (2.07e-1)" "unprognostic (4.04e-2)" "unprognostic (2.45e-1)" "unprognostic (1.19e-6)" "unprognostic (1.03e-1)" "unprognostic (1.10e-1)" "unprognostic (8.94e-3)" "unprognostic (1.39e-2)" 1.0 0.6 0.2 0.4 0.1 0.0 1.1 2.8 0.7 1.5 1.5 0.5 0.4 0.9 0.0 0.3 1.0 0.2 1.5 0.1 0.3 0.6 0.2 0.7 0.7 1.3 0.6 0.6 0.3 0.2 0.2 0.5 1.4 0.9 0.1 48.0 0.5 0.3 0.4 0.5 0.5 0.1 0.2 1.1 0.3 0.4 0.4 0.0 0.7 0.0 0.2 1.3 1.3 0.3 0.0 0.0 0.0 0.0 0.7 0.7 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 2.1 0.4 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 2.8 0.7 0.1 0.3 1.3 0.6 1.4 0.2 0.4 0.3 8.5 0.0 0.0 0.7 13.5 0.5 0.2 0.6 0.0 134.3 0.1 0.5 5.4 0.0 0.7 0.0 152.2 0.1 1.3 0.0 0.0 0.2 4.3 0.3 0.4 7.8 0.0 0.0 2.1 0.0 0.0 5.3 0.0 0.0 0.0 0.2 1.1 0.0 0.1 37.0 4.9 0.0 0.0 0.0 1.1 11.0 6.2 0.5 7.2 2.8 0.1 100.4 0.0 0.5 26.0 0.2 0.0 1.9 1.8 0.2 0.0 0.2 0.3 551.3 6.6 10.5 3.4 3.3 0.9 0.1 0.3 0.3 1.2 1.1 0.0 0.1 PRDM12 PFM9 ENSG00000130711 "PR/SET domain 12" Q9H4Q4 9 130664594-130682986 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Transcription, Transcription regulation" "DNA-binding, Methyltransferase, Transferase" "Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 13 "brain: 2.5" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 1.6;Excitatory neurons: 1.1" "Not detected" "Not detected" "Region enhanced" "Detected in some" "basal ganglia: 2.5" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 23 "RH-30: 19.1" "Region enriched" "Detected in some" 7 "basal ganglia: 10.9" "Group enriched" "Detected in some" 26 "basal ganglia: 3.8;hypothalamus: 1.3" HPA043143 Uncertain Approved Nucleoplasm "Intracellular and membrane" NA NA "Cluster 65: Brain - Ion transport" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 43: Cardiomyocytes - Nuclear processes" Nucleoplasm "HPA043143: AB_10806379" "unprognostic (3.25e-2)" "unprognostic (2.32e-1)" "unprognostic (3.40e-1)" "unprognostic (1.81e-4)" "unprognostic (7.90e-2)" "unprognostic (4.75e-3)" "unprognostic (2.48e-3)" "unprognostic (4.18e-2)" "unprognostic (4.61e-1)" "unprognostic (2.70e-1)" "unprognostic (6.43e-2)" "unprognostic (7.58e-2)" "unprognostic (4.03e-3)" "unprognostic (3.01e-2)" "unprognostic (4.79e-2)" "unprognostic (6.30e-4)" "unprognostic (1.40e-1)" 0.0 0.0 0.3 0.0 2.5 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 1.9 0.0 0.1 0.0 0.0 0.2 0.2 0.0 0.1 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.3 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.3 0.1 0.0 0.2 0.2 0.1 0.0 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.1 0.2 0.0 0.8 0.0 0.7 0.0 0.1 0.1 0.0 19.1 0.4 0.0 0.0 0.8 0.2 0.3 0.1 0.1 0.0 0.3 0.2 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.6 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 2.5 0.2 0.4 0.2 1.9 0.2 0.2 0.2 0.1 0.6 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.2 0.3 1.6 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 1.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.6 0.4 0.0 0.0 0.0 0.1 0.0 0.1 0.0 PRDM8 KMT8D ENSG00000152784 "PR/SET domain 8" Q9NQV8 4 80183879-80204329 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Neurogenesis, Transcription, Transcription regulation" "DNA-binding, Methyltransferase, Transferase" "Disease variant, Epilepsy, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "prostate: 26.1;seminal vesicle: 27.2" "Cell type enriched" "Detected in many" 9 "Bipolar cells: 271.5" "Cancer enhanced" "Detected in many" "prostate cancer: 4.6" "Region enhanced" "Detected in many" "cerebral cortex: 17.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "hTERT-RPE1: 27.3;LHCN-M2: 41.7;NB-4: 48.2;SCLC-21H: 99.3" "Region enhanced" "Detected in many" "hippocampal formation: 28.7" "Low region specificity" "Detected in all" HPA057253 Supported "Nucleoplasm,Nuclear bodies" No NA "Cluster 24: B-cells - Unknown function" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 56: Bipolar cells - Visual perception" "Nuclear bodies" Nucleoplasm "HPA057253: AB_2683382" "unprognostic (2.33e-2)" "unprognostic (1.08e-1)" "unprognostic (1.23e-1)" "unprognostic (2.67e-1)" "unprognostic (1.15e-1)" "unprognostic (1.68e-1)" "unprognostic (1.65e-1)" "unprognostic (7.95e-2)" "unprognostic (1.19e-1)" "unprognostic (1.76e-1)" "unprognostic (2.34e-1)" "unprognostic (2.80e-2)" "unprognostic (1.89e-11)" "unprognostic (4.64e-2)" "unprognostic (1.69e-1)" "unprognostic (1.39e-1)" "unprognostic (2.56e-1)" 4.8 2.3 5.1 5.0 10.2 4.0 4.0 0.0 17.0 11.7 0.0 11.4 1.1 9.3 1.9 1.7 5.2 1.7 1.7 13.7 0.0 1.3 0.3 1.6 5.1 0.0 0.0 5.2 0.9 0.0 5.4 4.3 0.0 26.1 1.5 24.1 1.4 27.2 2.2 2.7 5.7 3.8 0.6 1.8 5.0 1.1 0.1 0.7 1.2 0.9 2.4 10.2 9.8 3.2 2.3 0.2 0.7 0.0 2.1 7.2 0.1 5.8 20.5 2.8 3.2 0.0 2.2 0.0 0.0 7.2 1.8 0.7 0.1 2.4 12.1 8.8 1.8 0.8 0.0 0.0 4.1 9.1 2.5 4.4 0.2 11.1 3.2 27.3 0.4 2.4 0.0 3.7 41.7 0.0 4.2 48.2 0.0 0.2 17.0 1.6 0.0 0.2 1.2 0.3 99.3 13.8 0.3 0.0 0.1 0.1 0.0 4.5 8.8 7.1 1.0 5.2 0.4 1.7 0.0 0.0 17.8 4.2 1.0 0.0 0.0 0.0 0.4 0.0 0.6 0.1 0.5 0.5 0.1 0.7 0.3 0.1 0.5 0.2 0.0 0.1 0.2 0.1 5.1 10.2 0.0 17.0 13.7 0.0 0.0 0.0 0.0 0.6 0.1 3.2 0.9 0.0 0.5 2.3 8.2 0.6 3.4 0.4 0.0 271.5 0.1 0.4 1.8 0.0 5.2 1.8 2.1 0.0 2.5 0.0 0.0 0.0 1.5 0.3 6.5 2.2 0.0 2.5 29.9 0.2 0.2 8.8 0.0 0.5 0.0 0.1 0.0 0.0 0.5 3.3 2.0 0.2 2.0 1.2 6.2 6.7 3.1 5.9 1.8 3.7 0.9 6.1 2.1 7.1 17.0 0.7 0.0 3.4 2.7 3.7 0.0 0.2 5.0 11.6 0.0 4.2 2.9 0.3 0.4 0.0 0.1 0.1 5.0 0.1 0.0 0.6 PREPL KIAA0436 ENSG00000138078 "Prolyl endopeptidase like" Q4J6C6 2 44316281-44361862 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 243.1;Inhibitory neurons: 219.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063238 Approved NA NA "Cluster 44: Non-specific - Transcription" "Cluster 58: Brain - Synaptic function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA063238: AB_2684967" "unprognostic (5.60e-3)" "unprognostic (9.81e-2)" "unprognostic (4.51e-2)" "unprognostic (4.65e-3)" "unprognostic (2.22e-1)" "unprognostic (8.53e-2)" "unprognostic (5.98e-3)" "unprognostic (4.38e-3)" "unprognostic (2.27e-1)" "unprognostic (2.72e-2)" "unprognostic (1.52e-2)" "unprognostic (4.67e-2)" "unprognostic (2.33e-2)" "unprognostic (3.79e-1)" "unprognostic (1.87e-1)" "unprognostic (1.76e-1)" "unprognostic (1.75e-1)" 26.2 50.9 64.6 18.4 67.4 5.5 31.9 42.9 133.1 35.9 27.5 24.4 26.1 47.2 70.9 22.9 33.6 28.4 62.7 73.1 93.1 62.5 21.6 24.5 17.4 45.3 26.0 49.8 25.2 54.4 52.5 21.4 41.7 37.3 29.4 123.8 26.2 33.1 34.3 22.3 27.9 34.1 34.0 23.1 26.4 28.2 53.4 19.1 61.3 51.3 17.9 23.6 23.9 58.4 41.2 31.7 35.3 45.3 55.7 58.0 26.8 45.1 34.6 32.0 27.4 34.1 28.4 52.3 61.2 47.5 36.6 34.6 50.6 33.0 61.0 48.7 36.2 35.5 24.2 26.3 40.0 35.8 32.5 37.9 64.6 61.8 50.1 62.9 31.4 24.3 45.6 72.6 43.6 22.2 39.1 17.4 33.4 52.8 35.1 30.1 42.8 38.0 61.4 24.0 58.3 46.5 28.9 30.6 67.4 33.9 41.4 27.6 32.8 56.3 32.1 44.6 31.0 40.2 28.2 34.3 65.9 40.1 42.5 6.9 4.4 3.5 7.9 4.9 11.2 8.5 7.3 8.5 6.3 7.0 10.7 8.7 1.3 11.1 4.3 2.9 8.8 5.8 64.6 67.4 42.9 133.1 73.1 93.1 45.3 26.0 41.7 34.0 53.4 58.4 16.3 32.1 37.4 83.2 34.0 13.0 16.0 13.2 21.6 89.1 33.4 26.7 88.1 32.9 21.1 64.4 47.9 8.7 30.0 20.4 39.2 17.4 21.1 40.1 36.7 18.7 33.0 13.9 243.1 23.6 4.9 29.5 28.1 32.1 13.3 21.9 16.8 32.8 11.6 144.7 219.9 24.2 18.3 13.5 7.5 10.0 35.4 14.2 17.8 55.3 12.8 41.4 32.0 81.4 126.2 13.6 20.8 33.1 21.8 16.3 12.2 38.8 35.5 63.2 19.7 44.5 27.2 29.2 28.7 16.3 14.8 8.8 29.1 26.0 17.1 10.7 PRICKLE1 "EPM1B, FLJ31937, RILP" ENSG00000139174 "Prickle planar cell polarity protein 1" Q96MT3 12 42456757-42590355 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Epilepsy, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Early spermatids: 72.8;Excitatory neurons: 307.7;Inhibitory neurons: 122.2;Microglial cells: 64.6;Oligodendrocyte precursor cells: 114.6" "Cancer enhanced" "Detected in many" "thyroid cancer: 6.2" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "memory B-cell: 7.6;naive B-cell: 11.5" "Lineage enriched" "Detected in many" 4 "B-cells: 11.5" "Cell line enriched" "Detected in many" 18 "HBEC3-KT: 1015.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001379, HPA050037" Approved Approved Nucleoplasm NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 82: Adipose tissue - ECM organization" "Cluster 30: Epithelial cell lines - Translation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "HPA001379: AB_1855703, HPA050037: " "unprognostic (2.44e-1)" "unprognostic (2.50e-1)" "unprognostic (1.81e-2)" "unprognostic (2.48e-1)" "prognostic unfavorable (3.93e-4)" "unprognostic (1.22e-1)" "unprognostic (2.34e-4)" "unprognostic (3.53e-1)" "unprognostic (1.69e-2)" "unprognostic (5.89e-2)" "unprognostic (5.29e-2)" "unprognostic (7.77e-2)" "unprognostic (1.21e-3)" "unprognostic (2.29e-4)" "unprognostic (1.12e-1)" "unprognostic (8.95e-3)" "unprognostic (5.33e-4)" 6.3 3.0 3.7 5.2 5.0 1.7 5.0 0.0 7.2 12.5 0.0 4.2 2.6 12.1 1.6 2.4 6.4 10.0 13.8 4.2 0.0 5.0 1.7 9.5 4.6 0.1 1.3 12.5 2.0 1.4 2.0 5.3 0.0 5.1 2.2 4.2 7.8 5.6 3.9 4.7 2.4 12.7 0.0 14.8 2.9 6.0 3.9 1.6 7.9 4.6 3.4 5.5 6.3 1.0 7.7 4.4 17.0 0.5 12.4 13.1 0.5 11.0 5.2 3.0 5.1 0.5 16.0 0.5 31.4 1.6 0.0 2.9 12.5 1015.4 3.5 0.6 6.4 17.5 0.9 0.4 1.7 0.3 0.2 19.3 7.5 12.7 1.7 1.8 39.7 0.3 1.8 3.1 2.9 0.3 0.1 0.5 56.1 0.1 18.0 0.2 0.7 0.1 21.1 0.7 4.4 3.0 0.3 0.7 0.7 13.7 0.3 35.1 2.9 0.9 13.4 14.0 14.2 0.9 0.6 6.1 0.2 10.7 0.6 2.6 1.8 0.4 0.2 1.0 0.7 7.6 0.2 0.2 1.0 11.5 0.4 0.2 2.4 0.5 0.6 1.6 0.2 0.9 3.7 5.0 0.0 7.2 4.2 0.0 0.1 1.3 0.0 0.0 3.9 1.0 6.9 16.0 8.2 8.8 13.2 2.7 5.3 7.3 4.0 13.5 4.0 2.2 5.7 14.3 2.6 1.8 2.1 0.6 0.2 0.0 0.0 3.8 72.8 5.2 43.0 8.1 0.0 0.4 307.7 2.6 0.2 19.2 3.6 8.6 1.3 59.1 14.6 0.1 0.6 8.4 122.2 0.0 2.0 0.9 2.3 25.4 9.9 1.2 7.2 64.6 1.1 2.7 0.0 114.6 5.3 3.9 0.1 24.8 3.1 1.0 0.0 3.3 0.3 4.5 0.0 3.8 7.9 5.1 4.8 1.9 1.4 0.7 1.1 18.6 0.0 0.8 PRICKLE2 DKFZp686D143 ENSG00000163637 "Prickle planar cell polarity protein 2" Q7Z3G6 3 64092236-64445476 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Disease variant, Epilepsy, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 114.3;Excitatory neurons: 185.5;Inhibitory neurons: 232.4;Microglial cells: 112.4;Oligodendrocyte precursor cells: 103.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 24.1;ASC TERT1: 14.9;HSkMC: 22.1;U-87 MG: 15.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA035493 Approved "Golgi apparatus,Vesicles" NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Golgi apparatus" Vesicles "HPA035493: AB_10696504" "unprognostic (2.87e-1)" "unprognostic (4.31e-1)" "unprognostic (4.45e-2)" "unprognostic (1.25e-1)" "unprognostic (3.40e-1)" "unprognostic (3.53e-3)" "unprognostic (2.92e-2)" "unprognostic (1.56e-2)" "unprognostic (1.92e-1)" "unprognostic (3.83e-2)" "unprognostic (3.03e-2)" "unprognostic (6.35e-2)" "unprognostic (1.32e-3)" "unprognostic (1.10e-2)" "unprognostic (1.91e-1)" "unprognostic (9.04e-3)" "unprognostic (1.77e-1)" 20.8 3.0 14.1 3.9 14.9 0.3 8.0 3.4 15.8 16.4 9.1 18.4 2.3 17.3 6.8 7.7 11.7 8.8 5.6 28.5 10.0 3.8 3.1 10.6 0.8 4.4 8.9 8.4 3.8 5.4 5.6 5.6 6.2 7.3 4.6 10.1 4.9 13.8 1.9 4.3 5.9 16.6 6.3 1.4 8.1 1.7 11.7 1.0 6.9 3.9 1.0 12.4 8.8 9.3 0.0 4.7 1.3 0.1 24.1 14.9 0.0 3.5 4.5 2.8 4.2 8.3 0.1 0.0 0.5 3.4 7.6 0.1 0.0 3.2 2.8 3.3 0.1 0.0 0.5 0.1 6.7 0.0 0.0 22.1 4.0 8.2 3.5 8.4 1.7 0.0 0.0 1.8 3.9 4.6 0.0 0.1 3.0 0.0 0.1 0.0 0.2 0.1 4.5 11.7 1.2 0.2 0.0 0.9 0.1 7.7 1.6 0.1 0.1 11.9 5.4 2.9 6.9 3.7 0.0 0.7 15.5 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 14.1 14.9 3.4 15.8 28.5 10.0 4.4 8.9 6.2 6.3 11.7 9.3 12.4 0.0 10.9 114.3 1.5 6.2 4.1 7.3 7.4 25.6 4.3 8.4 6.2 1.5 7.3 3.7 64.6 1.4 0.3 1.6 0.0 2.7 15.1 24.7 47.5 9.5 0.0 0.0 185.5 0.4 0.4 20.3 0.0 8.7 0.0 5.2 33.5 1.7 4.1 16.8 232.4 0.6 4.1 1.2 1.8 3.5 9.9 0.6 5.4 112.4 0.0 7.5 1.0 103.5 26.4 0.7 0.3 23.0 0.2 0.9 0.0 6.2 7.6 4.4 13.1 14.6 14.3 2.0 1.0 6.2 3.0 4.9 0.6 6.6 1.1 2.7 PRIMPOL "CCDC111, FLJ33167" ENSG00000164306 "Primase and DNA directed polymerase" Q96LW4 4 184649667-184694963 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "DNA damage, DNA repair, Transcription" "DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Intestinal goblet cells: 58.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "eosinophil: 24.0" "Lineage enriched" "Detected in all" 4 "granulocytes: 24.0" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054372 Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 27: Mucus-secreting cells - Mucin production" Cytosol Nucleoplasm "HPA054372: AB_2682466" "unprognostic (1.68e-1)" "unprognostic (1.27e-3)" "unprognostic (1.67e-1)" "unprognostic (1.18e-1)" "unprognostic (2.67e-2)" "unprognostic (4.75e-2)" "unprognostic (2.02e-2)" "unprognostic (3.34e-2)" "unprognostic (3.32e-3)" "unprognostic (5.86e-2)" "unprognostic (2.52e-2)" "unprognostic (5.02e-1)" "unprognostic (3.04e-1)" "unprognostic (3.04e-2)" "unprognostic (3.81e-1)" "unprognostic (1.49e-1)" "unprognostic (1.05e-1)" 7.2 8.0 4.0 6.0 4.9 5.5 8.9 7.6 4.2 8.5 4.4 7.9 4.7 10.7 8.2 7.0 8.9 6.9 7.0 3.6 4.1 5.7 6.8 7.5 7.9 4.3 4.1 12.1 4.8 6.8 4.6 6.6 4.3 7.1 8.6 7.2 4.7 8.2 4.7 6.6 6.7 9.2 4.2 8.6 5.9 5.5 4.3 8.6 7.6 5.3 6.4 6.4 5.3 5.6 13.1 5.7 13.2 15.0 17.5 23.2 8.9 13.8 21.8 22.9 19.9 4.4 13.3 7.5 5.0 10.6 12.6 7.9 11.3 14.6 24.0 15.9 5.3 7.8 7.8 5.3 11.4 6.4 11.5 14.5 11.4 21.2 13.7 13.4 12.6 20.7 16.5 24.0 16.5 4.4 13.3 5.4 4.3 5.8 4.6 12.3 9.4 9.0 11.8 7.8 9.4 11.9 8.3 2.1 15.2 10.4 6.6 12.3 6.8 7.5 9.7 5.9 8.9 13.4 10.2 3.8 11.1 8.5 18.6 11.2 2.5 24.0 3.8 2.4 5.6 3.6 3.6 3.9 3.2 3.7 3.0 3.0 1.2 4.7 5.6 2.7 4.6 3.1 4.0 4.9 7.6 4.2 3.6 4.1 4.3 4.1 4.3 4.2 4.3 5.6 7.7 6.4 8.6 23.5 6.7 9.6 9.5 10.0 9.1 6.2 10.1 6.3 2.6 7.2 10.4 5.5 0.0 14.3 8.1 5.9 5.9 7.7 5.5 9.0 11.1 7.3 6.7 17.5 13.9 5.2 10.0 9.7 8.2 6.3 15.2 12.0 8.9 7.5 9.7 8.4 26.9 58.8 6.1 14.8 6.4 5.7 12.5 9.5 8.8 19.7 6.5 11.1 6.2 27.2 28.1 3.7 10.4 9.1 8.6 4.0 7.2 5.7 15.4 8.2 13.1 11.1 9.0 18.8 13.1 6.9 9.8 4.9 8.9 5.7 8.0 5.4 PRKCG "MGC57564, PKCγ, PKCC, PKCG, SCA14" ENSG00000126583 "Protein kinase C gamma" P05129 19 53879190-53907652 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Biological rhythms" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, FDA approved drug targets, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 20 "brain: 103.3" "Cell type enhanced" "Detected in some" "Excitatory neurons: 22.6;Glandular and luminal cells: 5.1;Horizontal cells: 5.0;Inhibitory neurons: 12.8" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in many" "hippocampal formation: 103.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 2.2;OE19: 4.0;SH-SY5Y: 1.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054560 Enhanced NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 21: OE19 - Mitochondria" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA054560: AB_2682523" "unprognostic (7.14e-2)" "unprognostic (5.42e-2)" "unprognostic (1.85e-1)" "unprognostic (3.86e-2)" "unprognostic (1.41e-1)" "unprognostic (5.38e-2)" "unprognostic (5.96e-2)" "unprognostic (4.46e-2)" "unprognostic (2.09e-1)" "unprognostic (2.64e-2)" "unprognostic (7.48e-3)" "unprognostic (2.68e-1)" "unprognostic (2.22e-7)" "unprognostic (2.41e-2)" "unprognostic (2.61e-1)" "unprognostic (1.06e-1)" "unprognostic (1.83e-1)" 0.1 0.0 47.5 0.2 44.8 0.9 0.0 5.8 64.8 0.0 0.0 0.3 0.4 0.1 0.0 0.0 0.5 0.1 0.0 103.3 4.0 0.0 0.0 0.0 0.0 0.0 3.5 0.1 1.8 3.9 1.4 0.0 0.0 0.0 0.2 0.3 0.1 0.0 0.1 0.0 0.5 0.1 0.6 0.0 0.6 5.2 12.6 3.4 0.0 0.2 0.0 0.0 0.0 18.3 0.1 2.2 0.4 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.5 0.6 0.1 0.6 0.0 0.2 0.2 1.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.9 0.0 0.0 0.2 0.0 0.4 0.0 0.5 0.0 0.0 0.0 0.2 0.2 0.0 0.3 4.0 0.1 0.4 0.2 0.0 0.4 0.0 0.0 1.5 0.6 0.0 0.0 0.7 0.7 0.0 0.4 0.0 0.7 0.0 0.0 0.6 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 47.5 44.8 5.8 64.8 103.3 4.0 0.0 3.5 0.0 0.6 12.6 18.3 1.1 0.0 0.0 1.0 0.7 0.1 0.1 0.0 0.0 0.0 2.3 4.6 0.7 0.0 0.0 0.0 0.0 0.0 0.8 0.2 0.0 0.1 4.2 1.2 2.0 0.5 0.0 0.0 22.6 0.0 0.2 0.6 2.0 5.1 0.0 0.0 0.0 0.0 0.1 5.0 12.8 1.5 0.0 0.0 0.0 1.8 0.0 0.6 0.0 2.8 0.0 0.0 0.0 3.0 2.0 0.2 0.0 0.0 1.0 0.1 0.0 0.0 0.1 0.2 0.0 4.0 0.4 2.9 0.9 0.1 0.0 0.0 0.2 0.0 0.4 0.1 PRKN "AR-JP, PARK2, parkin, PDJ" ENSG00000185345 "Parkin RBR E3 ubiquitin protein ligase" O60260 6 161347417-162727775 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, Transcription, Transcription regulation, Ubl conjugation pathway" Transferase "Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 28.3;tongue: 15.9" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 9.6;Alveolar cells type 2: 4.8;Distal tubular cells: 19.6;Proximal tubular cells: 6.8" "Cancer enhanced" "Detected in many" "renal cancer: 3.3" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "AN3-CA: 2.0;HEL: 4.1;HSkMC: 1.7;Karpas-707: 2.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB016257, HPA036012" Enhanced Supported "Nuclear speckles,Cytosol" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 36: HEL - Hemostasis" "Cluster 39: Non-specific - Basic cellular processes" "Nuclear speckles" Cytosol "CAB016257: AB_628104, HPA036012: AB_2732471" "unprognostic (9.23e-2)" "unprognostic (3.29e-2)" "unprognostic (6.48e-2)" "unprognostic (2.69e-3)" "unprognostic (9.85e-2)" "unprognostic (5.85e-2)" "unprognostic (7.07e-2)" "unprognostic (1.12e-1)" "unprognostic (1.39e-1)" "unprognostic (2.68e-2)" "unprognostic (1.03e-3)" "unprognostic (8.16e-2)" "prognostic favorable (6.75e-12)" "unprognostic (9.93e-2)" "unprognostic (1.51e-1)" "unprognostic (5.24e-2)" "unprognostic (2.50e-1)" 3.4 3.3 4.1 0.1 3.6 0.3 1.9 0.4 5.7 1.3 0.6 2.7 1.2 1.6 1.2 3.2 1.2 1.5 9.1 4.6 1.8 5.2 1.2 1.0 0.5 1.0 1.9 2.8 1.2 2.3 1.8 0.4 1.6 1.2 0.6 1.5 1.3 1.4 28.3 2.0 1.0 1.2 1.0 1.0 1.9 5.3 1.9 0.5 1.3 15.9 0.3 2.5 1.0 2.4 0.0 0.0 0.3 2.0 0.4 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.5 0.0 0.3 0.0 0.1 0.0 0.0 0.1 0.5 4.1 0.1 0.6 0.3 0.0 0.0 1.7 0.0 0.0 0.2 0.3 0.0 0.2 0.2 2.2 0.0 0.2 0.0 0.0 0.0 0.2 0.8 0.0 0.0 0.7 0.0 0.0 0.5 1.0 0.0 0.2 0.2 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.7 1.7 0.3 2.2 0.8 0.1 1.3 0.6 0.8 0.9 0.7 1.6 1.8 1.8 0.5 0.6 0.4 0.0 0.1 0.8 4.1 3.6 0.4 5.7 4.6 1.8 1.0 1.9 1.6 1.0 1.9 2.4 2.3 9.6 4.8 0.0 0.6 0.0 0.0 0.0 0.0 0.0 2.1 1.5 0.0 0.0 1.8 1.8 0.0 0.5 0.4 0.0 19.6 1.1 0.0 3.4 1.8 0.7 0.0 0.0 0.0 2.2 0.1 1.8 0.0 3.2 2.5 3.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 6.8 1.5 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.3 0.4 3.7 0.0 0.0 PRKRA "DYT16, HSD14, PACT, RAX" ENSG00000180228 "Protein activator of interferon induced protein kinase EIF2AK2" O75569 2 178431292-178451512 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Host-virus interaction, RNA-mediated gene silencing" RNA-binding "Disease variant, Dystonia, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 307.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004648, HPA034996, HPA034997" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 30: Epithelial cell lines - Translation" "Cluster 25: Spermatids - Spermatogenesis" Cytosol Nucleoplasm "CAB004648: AB_425767, HPA034996: AB_2674402, HPA034997: AB_2674403" "unprognostic (2.53e-1)" "unprognostic (9.18e-2)" "unprognostic (5.38e-2)" "unprognostic (4.02e-3)" "unprognostic (1.22e-1)" "unprognostic (1.04e-1)" "prognostic unfavorable (8.33e-5)" "unprognostic (9.66e-2)" "unprognostic (7.10e-3)" "unprognostic (2.32e-3)" "unprognostic (4.79e-2)" "unprognostic (1.29e-1)" "unprognostic (2.16e-3)" "unprognostic (8.99e-2)" "prognostic favorable (5.45e-4)" "unprognostic (1.38e-1)" "unprognostic (6.78e-2)" 28.7 21.9 22.1 13.8 22.6 18.2 26.4 24.6 31.3 23.6 25.3 36.4 13.7 28.7 25.7 22.8 23.4 17.5 37.2 22.8 24.9 29.7 20.2 21.2 16.9 25.0 22.5 23.4 25.4 26.2 22.5 11.5 24.2 23.4 20.1 30.9 22.6 24.3 100.7 31.2 19.7 29.4 25.2 15.9 26.0 24.3 23.1 20.4 22.1 72.7 20.4 32.1 22.0 27.1 24.6 18.4 48.2 20.8 49.2 56.7 39.6 35.4 37.7 46.4 50.8 50.9 33.8 51.0 39.8 43.6 30.9 21.0 42.0 28.5 50.9 43.9 25.0 29.2 17.0 46.7 58.6 21.2 16.1 32.2 69.3 44.0 49.7 46.0 46.8 32.8 26.7 34.9 62.9 25.3 46.3 52.2 46.7 42.3 33.5 38.5 89.0 46.6 52.4 25.5 30.2 39.4 21.9 20.2 48.3 36.3 30.6 27.4 20.8 32.0 42.6 33.8 29.9 52.5 33.7 62.6 40.8 35.1 20.7 5.4 24.7 25.9 18.1 25.5 26.2 34.3 28.4 22.7 37.2 26.4 31.4 25.8 5.1 25.2 26.3 49.7 38.3 30.9 22.1 22.6 24.6 31.3 22.8 24.9 25.0 22.5 24.2 25.2 23.1 27.1 35.1 16.0 33.4 23.2 37.7 63.1 90.0 89.3 30.1 53.6 48.1 40.3 43.5 20.0 39.9 25.8 43.8 37.7 49.3 16.9 125.2 51.4 149.5 43.6 36.2 34.5 47.9 19.1 39.5 41.6 53.2 42.7 19.4 27.0 28.5 40.5 21.8 18.5 30.4 10.1 46.4 35.5 93.6 19.8 69.4 307.9 39.4 26.4 69.4 21.5 38.6 49.2 9.2 30.7 47.1 36.0 25.1 37.2 42.5 94.7 30.8 89.0 30.6 86.2 46.0 45.6 66.7 78.7 57.6 43.7 78.4 43.4 33.6 47.0 39.6 73.0 PRNP "AltPrP, CD230, CJD, GSS, PRIP, PRP" ENSG00000171867 "Prion protein" P04156 20 4686350-4701590 "CD markers, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Cell cycle, Growth arrest" Prion "Amyloidosis, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Basal keratinocytes: 412.6;Basal squamous epithelial cells: 369.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 9 "basophil: 875.9" "Lineage enriched" "Detected in all" 9 "granulocytes: 875.9" "Cell line enhanced" "Detected in many" "WM-115: 1039.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042754, HPA043398" Enhanced Approved "Nuclear membrane,Vesicles,Cytosol" NA Yes 5100000 "Cluster 38: Basophils - Unknown function" "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 17: WM-115 - Nervous system development" "Cluster 41: Macrophages - Immune response" "Nuclear membrane, Cytosol" Vesicles "HPA042754: AB_10964203, HPA043398: AB_2678461" "unprognostic (1.50e-1)" "unprognostic (1.72e-1)" "prognostic unfavorable (2.96e-4)" "prognostic unfavorable (4.64e-4)" "prognostic unfavorable (2.52e-4)" "unprognostic (1.94e-2)" "prognostic unfavorable (7.41e-5)" "unprognostic (7.60e-3)" "unprognostic (2.50e-1)" "unprognostic (7.12e-2)" "unprognostic (3.44e-1)" "unprognostic (1.04e-1)" "unprognostic (6.75e-2)" "unprognostic (7.28e-3)" "unprognostic (3.37e-1)" "unprognostic (2.04e-1)" "unprognostic (1.69e-2)" 87.0 92.4 283.8 52.4 308.4 83.7 106.7 255.1 385.9 135.4 415.8 184.2 37.1 125.5 59.1 79.2 79.9 110.1 197.5 315.6 244.8 132.8 79.7 79.2 59.8 262.8 260.8 163.7 41.5 62.8 83.8 66.9 270.1 146.1 70.5 178.6 60.3 148.2 64.0 95.4 47.4 140.8 265.0 75.2 61.6 68.1 302.5 47.9 89.1 74.0 60.0 124.9 83.4 292.8 226.4 141.6 41.7 64.2 329.6 199.9 36.6 363.4 527.6 175.5 177.7 50.0 171.5 40.9 79.2 727.9 391.8 508.8 45.9 498.3 326.2 31.8 39.0 0.2 19.6 193.8 402.0 72.8 16.5 177.5 711.9 701.8 583.9 257.0 152.8 28.6 22.8 142.9 205.1 45.7 28.8 46.2 33.1 99.8 266.4 33.9 110.0 38.3 88.7 40.3 49.2 7.0 98.9 144.3 554.1 56.4 30.2 38.8 224.5 282.9 127.1 158.6 296.1 63.1 129.5 132.9 226.8 51.9 1039.0 875.9 74.1 5.4 67.3 60.9 100.7 25.1 56.9 55.8 62.9 25.6 33.5 40.1 4.6 23.6 50.4 24.6 72.8 72.7 283.8 308.4 255.1 385.9 315.6 244.8 262.8 260.8 270.1 265.0 302.5 292.8 44.9 80.1 45.4 120.2 85.3 412.6 211.8 132.5 369.3 265.4 60.8 103.0 257.7 32.9 68.2 33.1 116.7 7.7 71.8 2.6 11.7 58.1 6.0 14.1 73.2 66.7 29.9 31.8 125.5 14.7 6.3 177.4 14.8 18.2 173.0 25.5 41.0 36.2 63.6 45.4 170.8 5.4 40.7 219.1 200.4 13.6 143.2 126.3 168.9 59.0 54.5 142.4 42.2 95.0 158.8 18.7 4.5 170.0 47.0 120.3 2.2 84.0 38.1 99.0 13.1 73.0 82.3 36.6 4.5 81.6 284.4 14.4 107.2 10.3 8.8 122.6 PROM1 "AC133, CD133, CORD12, MCDR2, PROML1, RP41, STGD4" ENSG00000007062 "Prominin 1" O43490 4 15963076-16084378 "CD markers, Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Cone-rod dystrophy, Disease variant, Retinitis pigmentosa, Stargardt disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "retina: 272.9" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 581.7;Respiratory ciliated cells: 144.8;Rod photoreceptor cells: 311.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 37.2;CACO-2: 70.6;CAPAN-2: 28.9;EFO-21: 62.2;NTERA-2: 97.4;RPTEC TERT1: 91.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA004922, CAB011525, HPA031053" Enhanced NA NA "Cluster 79: Retina - Phototransduction" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 9: Photoreceptor cells - Phototransduction" "CAB011525: AB_470302, HPA004922: AB_1846238, HPA031053: AB_2673713" "unprognostic (6.33e-2)" "unprognostic (2.54e-1)" "unprognostic (1.53e-1)" "unprognostic (3.39e-1)" "unprognostic (2.81e-1)" "unprognostic (2.16e-1)" "unprognostic (2.39e-1)" "unprognostic (6.64e-2)" "unprognostic (2.18e-2)" "unprognostic (2.17e-1)" "unprognostic (1.21e-2)" "unprognostic (9.06e-2)" "prognostic favorable (2.56e-5)" "unprognostic (2.16e-2)" "unprognostic (1.02e-1)" "unprognostic (9.38e-2)" "unprognostic (1.17e-1)" 0.3 0.3 4.1 6.2 3.0 4.0 27.7 2.7 3.5 44.9 2.0 30.7 12.4 6.0 4.3 5.1 5.4 30.9 6.7 3.3 2.8 20.9 1.8 3.1 0.0 3.8 4.3 0.1 14.4 0.0 0.1 30.1 3.6 2.8 16.7 272.9 57.9 7.1 1.0 0.9 22.9 3.5 2.8 0.2 24.8 8.0 5.0 0.1 4.8 0.0 0.1 4.2 0.2 3.1 0.0 0.0 37.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 70.6 28.9 0.6 62.2 0.0 0.0 0.1 7.3 0.0 0.1 0.3 0.0 0.0 0.0 1.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.1 97.4 0.0 0.0 1.4 0.1 0.0 91.1 0.1 12.0 3.6 0.0 2.4 1.9 3.5 0.6 0.0 0.0 0.1 0.3 0.0 0.0 0.2 0.1 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.1 3.0 2.7 3.5 3.3 2.8 3.8 4.3 3.6 2.8 5.0 3.1 0.2 3.2 4.8 1.3 0.3 0.0 0.1 7.2 0.0 14.8 38.2 30.0 8.6 31.5 29.9 82.8 581.7 0.6 1.0 39.3 0.0 64.1 31.4 71.1 1.7 5.1 44.4 2.1 0.9 15.5 0.1 4.4 31.6 14.8 0.0 3.8 0.7 0.1 0.1 10.1 5.4 15.0 34.6 0.0 0.0 44.3 3.1 0.7 0.0 27.2 0.6 47.5 0.0 45.8 1.2 38.2 28.3 6.4 0.4 1.5 18.8 3.6 144.8 311.3 0.0 0.8 3.1 2.1 1.0 0.7 0.0 0.1 0.7 0.3 26.0 4.1 PRPF3 "hPrp3, Prp3, RP18, SNRNP90" ENSG00000117360 "Pre-mRNA processing factor 3" O43395 1 150321479-150353233 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "mRNA processing, mRNA splicing" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027226, HPA067116" Approved Enhanced Nucleoplasm NA NA "Cluster 44: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 43: THP-1 - Innate immune response" "Cluster 59: Non-specific - Transcription" Nucleoplasm "HPA027226: AB_1855770, HPA067116: AB_2685783" "unprognostic (2.75e-1)" "unprognostic (3.00e-1)" "unprognostic (2.20e-1)" "unprognostic (2.77e-1)" "unprognostic (1.78e-1)" "unprognostic (1.77e-1)" "prognostic unfavorable (6.59e-5)" "unprognostic (7.89e-2)" "unprognostic (7.13e-3)" "unprognostic (1.04e-2)" "unprognostic (1.42e-1)" "unprognostic (1.04e-2)" "prognostic unfavorable (3.19e-5)" "unprognostic (6.77e-3)" "unprognostic (1.65e-1)" "unprognostic (1.24e-1)" "unprognostic (7.78e-3)" 26.0 24.7 18.1 22.3 20.2 44.8 27.0 23.2 23.1 27.5 22.8 25.2 16.9 25.0 26.7 22.2 25.7 13.8 19.5 17.8 21.4 29.0 30.4 24.3 28.6 19.7 18.9 34.1 23.8 17.6 27.0 20.9 19.3 27.5 19.6 43.5 21.7 19.5 22.2 23.8 24.6 18.7 17.3 33.8 19.1 20.1 19.7 30.9 32.0 14.9 28.5 24.3 24.3 21.6 44.8 47.5 47.1 30.3 31.0 33.5 63.8 45.6 31.9 69.1 47.5 36.6 40.8 58.7 29.7 37.6 64.4 51.5 86.1 32.2 61.7 29.7 38.3 50.7 72.1 35.2 30.7 62.5 31.6 24.6 43.7 59.0 50.5 32.9 42.7 39.0 61.3 34.8 50.0 66.5 52.3 55.0 67.6 114.3 41.9 75.1 38.5 38.8 28.5 26.7 40.3 35.7 37.9 44.2 34.9 63.3 52.9 150.5 34.3 43.2 33.3 36.7 75.8 33.1 62.8 64.7 28.8 56.2 45.9 9.3 9.0 13.3 14.9 11.8 14.6 13.0 10.8 9.8 9.5 10.0 11.0 11.4 5.3 11.5 21.8 7.6 9.1 8.3 18.1 20.2 23.2 23.1 17.8 21.4 19.7 18.9 19.3 17.3 19.7 21.6 26.1 35.3 23.4 31.6 26.1 11.7 13.1 13.0 10.8 30.4 10.8 10.8 13.2 11.5 19.7 11.0 18.8 16.1 22.9 15.8 13.7 15.6 11.5 13.2 20.0 22.5 2.4 19.0 19.5 11.9 16.0 16.3 17.9 17.8 22.8 25.5 14.6 11.0 12.1 32.0 17.5 17.5 4.1 8.6 11.8 5.3 20.2 14.5 10.6 15.0 14.2 27.8 17.5 18.1 28.4 13.4 9.5 18.4 12.4 12.6 12.6 5.0 20.6 42.6 13.1 19.1 21.2 44.3 23.5 11.6 10.1 20.0 24.0 11.3 11.6 10.0 PRPF31 "hPrp31, NY-BR-99, PRP31, RP11, SNRNP61" ENSG00000105618 "Pre-mRNA processing factor 31" Q8WWY3 19 54115410-54131719 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "mRNA processing, mRNA splicing" "Ribonucleoprotein, RNA-binding" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041939, HPA061873" Supported Supported Nucleoplasm NA NA 13000 "Cluster 27: Non-specific - Gene expression" "Cluster 72: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Nucleoplasm "HPA041939: AB_10793938, HPA061873: AB_2684630" "unprognostic (1.32e-1)" "unprognostic (1.73e-2)" "unprognostic (1.26e-2)" "unprognostic (7.98e-2)" "unprognostic (1.28e-1)" "unprognostic (3.28e-2)" "prognostic unfavorable (7.33e-4)" "unprognostic (9.55e-2)" "unprognostic (2.16e-1)" "unprognostic (1.66e-1)" "unprognostic (5.26e-3)" "unprognostic (1.81e-2)" "unprognostic (2.06e-1)" "unprognostic (2.16e-1)" "unprognostic (5.94e-2)" "unprognostic (2.53e-1)" "unprognostic (7.04e-2)" 35.1 36.0 26.1 24.3 27.5 33.2 35.1 26.6 31.3 39.6 26.9 42.3 23.1 39.7 12.5 37.8 35.3 18.9 38.8 26.7 26.1 34.2 44.5 29.7 33.2 27.0 26.3 39.0 29.3 28.6 33.7 23.1 26.7 37.6 13.9 8.1 33.9 23.6 48.2 40.2 34.6 19.0 25.5 39.7 35.7 33.0 27.2 26.3 36.5 23.7 23.4 38.3 35.6 28.5 83.7 169.4 55.0 89.8 34.6 33.0 59.4 68.3 53.1 74.6 72.5 82.4 63.8 89.1 54.2 49.9 36.0 49.8 64.6 78.6 46.4 82.4 298.4 66.6 108.3 97.0 51.7 120.9 59.7 54.2 36.0 62.3 43.1 39.4 79.4 74.4 96.8 46.2 49.9 82.8 103.3 64.1 53.4 78.5 187.1 89.2 71.7 81.5 51.8 120.8 61.6 72.8 88.0 83.2 44.7 24.5 52.3 62.5 81.2 100.4 84.7 43.6 109.0 58.6 97.7 98.5 75.7 81.9 71.0 25.0 44.3 30.1 47.9 53.1 51.8 43.5 47.2 51.4 52.9 44.5 39.7 40.5 9.1 54.4 48.6 45.6 61.0 51.1 26.1 27.5 26.6 31.3 26.7 26.1 27.0 26.3 26.7 25.5 27.2 28.5 38.7 35.3 26.7 17.0 35.0 42.7 38.9 96.1 46.7 31.4 31.3 37.6 35.9 32.9 54.2 25.8 14.6 95.0 40.2 29.3 60.7 74.6 5.9 34.9 34.9 47.3 34.8 32.4 13.4 62.9 90.8 42.0 33.6 31.0 31.7 53.5 27.8 27.3 66.4 30.3 12.4 38.9 57.0 22.2 43.2 7.4 38.2 33.7 40.9 9.4 61.2 51.1 48.4 13.6 14.9 63.2 30.1 48.9 34.0 37.6 46.9 62.0 43.6 32.2 39.5 36.1 53.4 125.2 77.9 33.9 42.1 76.2 41.5 54.3 46.3 32.8 PRPF4 "HPRP4, HPRP4P, PRP4, Prp4p, SNRNP60" ENSG00000136875 "Pre-mRNA processing factor 4" O43172 9 113275642-113294009 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "mRNA processing, mRNA splicing" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021794, HPA022248" Enhanced Enhanced "Nuclear speckles" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" "Nuclear speckles" "HPA021794: AB_1855772, HPA022248: AB_1855773" "unprognostic (1.70e-2)" "unprognostic (6.51e-2)" "unprognostic (3.60e-2)" "unprognostic (1.36e-1)" "unprognostic (1.69e-1)" "unprognostic (3.70e-3)" "prognostic unfavorable (9.35e-4)" "unprognostic (1.95e-2)" "unprognostic (6.57e-2)" "unprognostic (3.14e-2)" "unprognostic (5.00e-2)" "unprognostic (6.76e-3)" "unprognostic (2.18e-3)" "unprognostic (4.43e-2)" "unprognostic (1.29e-1)" "unprognostic (1.42e-1)" "unprognostic (1.57e-2)" 11.6 14.7 9.2 15.2 9.5 15.1 13.4 10.3 10.9 11.2 8.6 11.1 9.9 13.5 19.4 14.9 12.3 10.3 11.0 9.4 9.5 15.4 16.2 9.4 15.6 8.9 8.9 14.8 14.4 25.4 12.2 12.5 9.2 13.3 12.3 13.1 11.2 11.1 18.1 14.6 9.8 13.2 9.0 11.6 10.3 11.6 9.1 16.9 10.2 15.2 17.6 16.7 11.3 9.6 36.6 61.3 40.3 44.4 27.8 28.6 40.4 56.1 28.1 60.2 44.2 60.4 33.4 76.5 32.5 30.3 62.2 81.8 84.9 48.8 66.2 54.2 32.1 39.1 50.4 43.7 25.2 68.0 34.2 20.7 32.7 63.1 59.9 22.6 28.9 41.8 67.5 40.9 51.2 57.3 65.1 47.9 63.9 94.2 66.5 59.4 95.9 51.4 26.0 28.9 52.7 35.5 82.9 44.0 26.0 32.0 68.3 35.0 29.8 49.1 37.3 63.0 72.4 52.1 153.1 73.3 37.6 42.9 63.8 27.4 16.2 16.1 14.7 19.4 17.1 17.1 14.4 13.3 20.4 17.4 14.5 14.6 5.2 18.4 24.6 13.4 14.6 14.8 9.2 9.5 10.3 10.9 9.4 9.5 8.9 8.9 9.2 9.0 9.1 9.6 15.7 9.6 18.4 6.8 23.7 15.7 17.6 10.4 18.8 22.9 12.7 14.6 12.9 12.8 15.2 18.4 18.8 27.7 26.6 5.8 25.4 18.6 17.2 17.5 24.7 12.6 17.5 20.0 8.6 16.9 34.5 16.4 10.2 21.9 19.0 21.5 6.4 9.9 18.4 28.6 8.3 13.0 10.2 13.5 17.8 13.0 11.5 20.5 5.4 2.8 27.3 22.7 18.6 4.0 5.7 15.5 9.6 10.9 15.7 20.6 8.1 16.9 14.3 24.1 0.0 16.9 17.5 28.6 21.0 21.4 18.8 21.5 20.0 24.7 14.0 16.9 PRPF6 "ANT-1, bB152O15.1, C20orf14, hPrp6, Prp6, RP60, SNRNP102, TOM, U5-102K" ENSG00000101161 "Pre-mRNA processing factor 6" O94906 20 63981132-64033100 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "mRNA processing, mRNA splicing" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA047106 Supported Supported "Nuclear speckles" NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 39: CACO-2 - Unknown function" "Cluster 52: Non-specific - Transcription" "Nuclear speckles" "HPA047106: AB_10963084" "unprognostic (1.29e-1)" "unprognostic (9.96e-3)" "unprognostic (7.02e-2)" "unprognostic (9.36e-3)" "unprognostic (1.80e-1)" "unprognostic (2.34e-1)" "unprognostic (1.66e-3)" "unprognostic (3.37e-2)" "unprognostic (1.44e-2)" "unprognostic (1.14e-1)" "unprognostic (5.76e-3)" "unprognostic (2.18e-1)" "unprognostic (3.16e-3)" "unprognostic (6.16e-2)" "unprognostic (8.04e-2)" "unprognostic (7.19e-2)" "unprognostic (5.39e-3)" 44.0 32.2 33.6 30.8 37.4 33.3 40.1 44.9 37.1 38.5 34.5 39.9 30.0 43.5 27.9 38.9 49.3 27.2 39.0 32.9 34.7 35.3 29.8 32.1 40.9 37.7 35.5 50.6 44.2 37.2 36.7 30.9 37.1 34.5 25.9 36.4 38.3 36.4 64.6 58.3 38.1 29.7 34.6 40.9 37.3 41.0 35.5 44.4 36.2 37.1 40.5 40.5 36.2 46.8 72.8 86.5 62.3 66.3 69.5 48.6 81.5 56.1 62.8 167.9 74.6 233.6 86.2 90.9 133.4 74.5 107.1 110.0 101.2 116.1 88.7 44.0 59.0 76.8 112.7 213.3 76.7 105.3 102.3 55.2 81.4 77.5 89.2 59.9 63.3 83.7 76.2 76.6 56.8 89.2 106.8 131.0 55.4 114.4 106.7 116.0 53.0 87.3 64.4 71.9 61.8 72.4 108.6 110.0 74.1 43.2 108.0 135.5 90.1 96.2 55.1 77.4 104.6 63.7 66.5 94.6 70.3 62.5 76.3 90.8 59.7 73.7 67.0 62.7 93.3 67.1 82.3 72.5 58.6 58.4 95.8 80.9 50.3 130.5 77.8 54.5 79.7 92.3 33.6 37.4 44.9 37.1 32.9 34.7 37.7 35.5 37.1 34.6 35.5 46.8 60.7 60.9 62.6 19.2 69.3 38.4 45.3 50.7 63.2 81.6 54.2 59.8 70.5 34.3 71.6 62.5 37.5 72.5 53.2 43.8 82.2 59.3 49.1 70.3 66.8 55.7 52.7 43.5 12.5 56.7 47.6 51.2 38.7 62.0 91.2 49.0 63.9 55.2 46.3 42.1 14.8 60.6 57.0 44.8 34.1 28.7 58.1 49.9 48.0 5.6 79.7 86.5 57.7 12.5 17.8 65.9 43.9 52.6 67.8 33.5 58.0 65.8 87.7 112.7 59.2 68.2 61.9 120.6 118.9 59.8 46.3 94.5 60.0 32.6 47.7 34.3 PRPF8 "hPrp8, Prp8, PRPC8, RP13, SNRNP220" ENSG00000174231 "Pre-mRNA processing factor 8" Q6P2Q9 17 1650629-1684867 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "mRNA processing, mRNA splicing" "Ribonucleoprotein, RNA-binding" "Cancer-related genes, Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 252.3;Rod photoreceptor cells: 293.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009941, CAB015457" Supported Enhanced Nucleoplasm NA NA 120000 "Cluster 44: Non-specific - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 39: CACO-2 - Unknown function" "Cluster 9: Photoreceptor cells - Phototransduction" Nucleoplasm "CAB009941: AB_2171185, CAB015457: AB_831685" "unprognostic (1.23e-1)" "unprognostic (1.49e-1)" "unprognostic (2.76e-2)" "unprognostic (3.13e-2)" "unprognostic (1.56e-1)" "unprognostic (4.94e-2)" "unprognostic (6.58e-2)" "unprognostic (1.56e-1)" "unprognostic (4.19e-2)" "unprognostic (1.77e-1)" "unprognostic (2.69e-2)" "unprognostic (1.04e-1)" "unprognostic (2.45e-3)" "unprognostic (2.00e-1)" "unprognostic (2.66e-1)" "unprognostic (1.16e-1)" "unprognostic (1.23e-1)" 78.5 128.7 82.6 45.7 85.0 70.5 78.6 93.2 121.3 98.5 98.7 93.5 33.0 94.5 44.1 85.3 94.2 30.8 100.9 84.4 84.0 78.2 91.2 84.2 52.8 83.6 82.1 131.6 78.3 82.7 130.4 44.7 86.2 89.7 44.5 115.6 78.1 49.1 146.7 92.6 84.2 51.7 80.9 98.2 80.5 100.1 81.5 83.9 89.0 80.1 61.6 96.9 84.3 88.0 104.0 240.7 149.0 116.1 120.8 90.4 107.9 78.2 109.5 160.3 122.4 208.2 50.0 150.0 73.2 150.5 113.4 152.9 356.3 139.5 181.6 99.4 170.0 124.3 187.1 161.0 73.5 145.4 138.9 86.0 91.2 194.8 146.7 84.5 146.1 106.2 121.1 126.6 117.9 112.7 114.4 117.4 97.0 97.7 74.4 218.4 82.3 80.7 63.1 121.1 71.0 103.8 145.0 61.5 69.3 121.6 87.4 91.3 122.1 91.7 78.3 130.2 176.1 46.6 46.7 101.9 81.6 108.1 121.6 23.1 8.9 10.1 19.1 14.4 23.6 17.5 17.7 20.9 15.7 18.3 16.7 20.0 9.0 14.2 21.7 25.2 23.2 11.2 82.6 85.0 93.2 121.3 84.4 84.0 83.6 82.1 86.2 80.9 81.5 88.0 45.7 60.9 84.3 24.5 72.8 30.1 30.0 42.5 56.9 128.0 31.8 34.4 39.4 42.9 53.9 47.8 252.3 43.3 66.6 42.9 7.9 35.5 11.8 45.4 38.8 46.3 36.5 73.0 23.6 40.9 26.7 48.3 56.1 40.3 52.6 55.9 37.9 38.7 39.8 72.3 29.3 40.2 32.6 40.1 26.5 11.2 73.3 42.6 19.6 19.7 48.3 55.9 46.4 21.6 19.0 42.7 36.5 52.3 70.0 31.4 48.7 18.3 51.3 293.2 72.3 65.4 44.8 100.4 99.1 57.3 27.8 39.5 62.8 50.2 50.3 31.5 PRPH "NEF4, PRPH1" ENSG00000135406 Peripherin P41219 12 49293252-49298686 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Amyotrophic lateral sclerosis, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 53.6;intestine: 21.0" "Group enriched" "Detected in some" 6 "Early spermatids: 327.5;Late spermatids: 920.2" "Group enriched" "Detected in some" 4 "endometrial cancer: 1.6;glioma: 1.7;pancreatic cancer: 1.1;testis cancer: 1.5" "Group enriched" "Detected in many" 5 "medulla oblongata: 51.9;pons: 53.6;white matter: 15.7" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "AN3-CA: 367.0" "Group enriched" "Detected in many" 4 "hypothalamus: 19.4;pons and medulla: 35.1" "Region enriched" "Detected in many" 8 "spinal cord: 256.8" "CAB002437, HPA039277, HPA063887" Enhanced NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 31: Spermatids - Spermatogenesis" "CAB002437: AB_563956, HPA039277: AB_2676424, HPA063887: AB_2685142" "unprognostic (1.73e-2)" "unprognostic (3.03e-1)" "unprognostic (1.11e-1)" "unprognostic (1.87e-1)" "prognostic unfavorable (7.88e-4)" "unprognostic (5.04e-3)" "unprognostic (1.88e-2)" "unprognostic (6.29e-2)" "unprognostic (1.87e-1)" "unprognostic (2.10e-1)" "unprognostic (7.38e-2)" "unprognostic (1.24e-1)" "unprognostic (4.25e-3)" "unprognostic (3.63e-2)" "unprognostic (5.73e-2)" "unprognostic (4.86e-3)" "unprognostic (6.36e-5)" 3.1 14.5 0.9 7.5 1.1 0.0 1.8 0.3 1.8 3.3 0.4 21.0 4.7 0.8 0.1 0.5 3.1 0.6 1.2 0.9 2.2 0.9 0.1 0.9 0.2 51.9 8.0 0.7 1.3 0.1 2.9 0.3 53.6 2.3 2.1 1.5 0.5 1.5 0.4 1.1 8.9 2.0 7.8 1.2 5.2 13.2 0.9 0.1 0.5 0.2 0.1 1.5 8.3 15.7 0.0 0.7 0.0 367.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.8 0.7 0.0 0.8 0.0 0.1 0.0 0.4 0.0 0.0 0.7 1.6 0.4 1.3 0.2 0.2 0.4 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 3.7 0.0 0.2 2.0 0.0 2.2 0.4 0.0 1.6 86.6 1.5 0.2 0.8 0.0 0.0 1.7 0.1 0.0 1.1 0.0 0.0 0.0 0.4 0.0 0.0 0.2 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 1.1 0.3 1.8 0.9 2.2 51.9 8.0 53.6 7.8 0.9 15.7 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 10.8 0.3 0.8 0.4 0.0 0.0 0.0 4.2 0.1 0.0 0.1 0.0 0.0 327.5 0.5 0.1 1.4 92.3 0.0 0.1 0.0 0.2 0.4 0.0 0.3 0.0 0.0 0.0 0.0 0.1 25.2 0.1 1.0 0.0 0.0 0.9 920.2 5.9 0.7 0.0 0.0 0.0 9.3 0.0 0.0 0.0 0.1 0.0 1.9 0.0 0.0 0.0 0.8 0.1 38.1 0.0 0.1 14.1 96.1 19.4 0.3 0.4 0.0 0.1 0.0 0.5 0.2 PRPH2 "CACD2, rd2, RDS, RP7, TSPAN22" ENSG00000112619 "Peripherin 2" P23942 6 42696598-42722597 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Cell adhesion, Sensory transduction, Vision" "Cone-rod dystrophy, Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 48 "retina: 641.4" "Group enriched" "Detected in some" 8 "Cone photoreceptor cells: 260.6;Rod photoreceptor cells: 482.7" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC diff: 3.0;ASC TERT1: 3.4;fHDF/TERT166: 5.3;HHSteC: 7.8;HSkMC: 6.0;LHCN-M2: 3.5" "Region enriched" "Detected in single" 7 "hippocampal formation: 2.4" "Not detected" "Not detected" HPA029458 Enhanced NA NA "Cluster 10: Basophils - Unknown function" "Cluster 79: Retina - Phototransduction" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA029458: AB_10602193" "unprognostic (2.37e-1)" "unprognostic (4.88e-2)" "unprognostic (6.67e-2)" "unprognostic (8.43e-2)" "unprognostic (1.15e-1)" "unprognostic (2.87e-3)" "unprognostic (4.73e-1)" "unprognostic (1.85e-1)" "unprognostic (6.87e-2)" "unprognostic (1.09e-1)" "unprognostic (1.44e-1)" "unprognostic (3.18e-2)" "unprognostic (7.07e-4)" "unprognostic (1.13e-3)" "unprognostic (1.59e-1)" "unprognostic (8.42e-2)" "unprognostic (8.96e-3)" 1.1 0.8 2.1 0.5 1.5 0.0 0.5 0.4 1.8 2.0 0.1 2.2 0.4 2.1 1.8 0.7 1.3 1.1 1.5 3.1 2.1 1.4 0.2 1.5 0.1 0.9 1.0 3.1 2.3 4.3 2.5 0.9 1.2 1.5 0.8 641.4 0.7 1.1 13.2 0.3 1.4 1.9 0.4 0.8 1.2 3.7 2.7 0.2 4.1 2.9 0.1 1.2 1.1 1.2 0.0 0.0 0.0 0.0 3.0 3.4 0.7 0.9 0.0 0.1 0.0 0.0 0.0 0.0 0.0 5.3 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 7.8 0.0 0.0 6.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.7 0.0 0.2 0.0 0.1 0.0 2.1 1.5 0.4 1.8 3.1 2.1 0.9 1.0 1.2 0.4 2.7 1.2 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 39.3 0.1 0.0 0.9 0.0 0.1 0.0 260.6 0.1 0.0 0.0 3.9 0.3 0.2 0.1 0.9 2.3 0.0 0.0 2.3 0.2 0.0 1.3 0.0 0.1 0.0 0.2 0.4 0.2 0.0 11.8 1.7 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 1.9 0.0 42.6 1.0 0.5 0.6 0.5 0.0 1.9 0.0 0.2 0.0 0.2 0.0 482.7 0.0 0.9 0.8 2.3 0.5 0.1 0.3 0.1 0.0 1.3 0.0 0.1 PRPS1 "CMTX5, DFN2, DFNX1" ENSG00000147224 "Phosphoribosyl pyrophosphate synthetase 1" P60891 X 107628428-107651993 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Nucleotide biosynthesis" "Kinase, Transferase" "Charcot-Marie-Tooth disease, Deafness, Disease variant, Gout, Mental retardation, Neurodegeneration, Neuropathy, Non-syndromic deafness, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043760, HPA051269" Uncertain Approved Vesicles NA NA 320000 "Cluster 13: T-cells - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 24: Non-specific - Transcription regulation" Vesicles "HPA043760: AB_2678656, HPA051269: " "unprognostic (4.47e-2)" "unprognostic (6.18e-2)" "unprognostic (2.57e-2)" "unprognostic (4.19e-3)" "unprognostic (2.30e-3)" "unprognostic (2.56e-3)" "unprognostic (3.24e-2)" "unprognostic (1.14e-1)" "unprognostic (1.46e-1)" "unprognostic (9.73e-2)" "unprognostic (1.91e-2)" "unprognostic (4.11e-2)" "unprognostic (2.85e-2)" "unprognostic (4.57e-2)" "unprognostic (1.29e-1)" "unprognostic (1.25e-2)" "unprognostic (5.25e-2)" 22.9 28.0 33.7 30.2 35.0 58.0 21.0 32.4 36.4 20.0 59.3 19.0 11.0 23.7 14.8 13.7 25.9 13.9 22.2 33.7 39.6 27.6 51.5 21.5 42.7 35.4 39.1 30.2 21.7 27.2 23.2 14.6 37.6 21.3 17.9 30.2 16.3 17.4 49.1 12.3 16.7 29.5 34.2 26.2 15.5 13.4 35.2 52.0 44.1 37.9 45.7 23.6 15.2 34.4 93.5 128.9 56.4 69.9 32.7 26.5 18.6 253.2 55.8 146.0 122.6 55.5 36.6 156.9 111.7 94.9 104.1 36.6 176.0 53.8 148.3 79.9 150.9 84.2 140.0 100.3 28.8 153.1 55.6 28.2 30.6 90.2 56.2 96.7 52.3 108.2 137.4 183.5 69.0 51.0 101.2 113.6 213.5 77.2 141.4 117.6 96.3 125.4 60.7 54.2 96.2 52.5 131.5 77.6 57.3 106.4 36.0 61.7 31.2 93.2 45.0 108.3 109.1 61.8 115.1 172.7 50.1 163.6 61.6 8.8 8.9 22.6 26.0 14.3 30.8 29.3 31.7 32.2 11.4 31.0 36.1 30.7 4.7 28.5 15.7 16.3 35.5 21.1 33.7 35.0 32.4 36.4 33.7 39.6 35.4 39.1 37.6 34.2 35.2 34.4 21.0 6.4 10.0 4.6 44.2 31.1 18.4 13.2 12.0 28.4 8.3 9.4 12.1 15.7 12.6 16.5 4.2 8.8 29.3 3.0 25.4 18.3 1.2 11.5 13.3 18.1 16.2 52.2 4.8 20.2 11.5 22.2 10.2 5.7 26.6 13.2 14.6 57.5 35.3 15.2 10.0 6.5 6.1 18.6 34.8 3.9 14.0 16.8 26.6 6.5 24.9 20.0 27.8 3.5 4.8 19.1 3.7 17.0 35.7 16.2 1.5 29.4 27.1 14.1 0.0 18.1 30.7 3.6 10.9 10.8 22.3 1.8 45.0 19.7 8.0 9.7 PRRT2 "DKFZp547J199, DSPB3, DYT10, EKD1, FICCA, FLJ25513, ICCA, IFITMD1, PKC" ENSG00000167371 "Proline rich transmembrane protein 2" Q7Z6L0 16 29811382-29815892 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Disease variant, Dystonia, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "ovary: 124.3" "Cell type enhanced" "Detected in many" "Bipolar cells: 82.3;Cone photoreceptor cells: 31.3;Leydig cells: 36.1;Peritubular cells: 40.3;Rod photoreceptor cells: 37.1" "Cancer enhanced" "Detected in many" "glioma: 5.8" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 7 "NK-cell: 3.2" "Lineage enriched" "Detected in single" 7 "NK-cells: 3.2" "Cell line enhanced" "Detected in many" "AF22: 24.1;HeLa: 13.8;hTERT-RPE1: 14.0;REH: 17.6;U-138 MG: 14.5" "HPA014447, HPA019203, HPA048045" Enhanced Supported "Plasma membrane" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 35: Non-specific - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 56: Bipolar cells - Visual perception" "Plasma membrane" "HPA014447: AB_1855786, HPA019203: AB_2670097, HPA048045: " "unprognostic (7.60e-3)" "unprognostic (3.00e-1)" "unprognostic (8.32e-3)" "unprognostic (4.34e-2)" "unprognostic (3.72e-2)" "unprognostic (1.19e-3)" "unprognostic (2.85e-1)" "unprognostic (1.23e-1)" "unprognostic (9.30e-2)" "unprognostic (1.93e-1)" "unprognostic (4.45e-2)" "unprognostic (3.26e-2)" "unprognostic (3.43e-8)" "unprognostic (1.22e-1)" "unprognostic (1.17e-1)" "unprognostic (5.12e-2)" "unprognostic (2.44e-2)" 13.4 10.5 32.9 2.4 40.4 0.3 10.8 70.7 70.5 79.4 0.0 33.9 5.3 39.5 8.6 6.7 47.0 10.9 15.6 46.0 20.1 8.7 2.4 12.9 3.3 15.6 8.0 124.3 4.7 4.3 85.6 7.0 16.2 39.1 2.3 19.8 5.4 13.9 4.5 5.0 14.5 10.4 24.5 1.7 12.4 14.6 29.2 0.5 10.6 1.8 1.0 34.1 51.0 34.0 0.1 1.5 24.1 8.6 1.2 4.2 0.5 2.5 4.1 1.0 0.8 1.1 1.5 0.2 0.3 4.4 0.5 1.6 3.4 0.2 0.4 4.1 1.4 1.7 13.8 1.6 0.3 0.0 0.3 4.1 0.1 1.9 0.1 14.0 1.0 0.7 0.2 1.5 0.2 3.1 0.6 0.5 5.0 0.1 1.1 17.6 0.9 0.4 0.2 0.8 4.1 4.3 0.2 2.1 0.5 3.5 7.6 0.0 1.3 14.5 5.2 0.7 1.4 3.7 0.5 0.2 5.3 0.2 0.5 0.4 0.0 0.1 0.0 0.0 0.1 0.0 0.2 0.1 0.0 0.0 0.1 0.1 0.1 3.2 0.1 0.0 0.0 0.1 32.9 40.4 70.7 70.5 46.0 20.1 15.6 8.0 16.2 24.5 29.2 34.0 2.3 3.2 0.0 22.9 0.9 1.1 1.4 1.7 0.6 82.3 1.6 1.7 0.8 1.5 1.2 0.0 31.3 1.9 1.9 9.5 1.9 1.1 2.0 4.4 10.4 5.0 6.1 0.0 24.4 1.5 0.8 11.4 2.0 1.6 0.0 1.7 3.3 0.1 0.4 20.2 19.5 4.2 2.0 0.0 2.4 9.8 36.1 0.5 0.0 5.6 0.6 5.7 1.0 8.5 1.6 3.0 9.0 40.3 0.7 1.8 15.2 1.0 5.6 37.1 6.6 2.9 11.7 2.4 3.1 0.4 0.4 2.6 2.7 0.6 2.5 1.3 PRX KIAA1620 ENSG00000105227 Periaxin Q9BXM0 19 40393766-40414793 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Charcot-Marie-Tooth disease, Dejerine-Sottas syndrome, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lung: 34.6" "Cell type enhanced" "Detected in many" "Adipocytes: 17.8;Breast myoepithelial cells: 23.2;Cardiomyocytes: 15.4;Skeletal myocytes: 30.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Region enriched" "Detected in some" 8 "spinal cord: 114.2" HPA001868 Enhanced Approved "Golgi apparatus,Vesicles,Plasma membrane" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 29: U-266 - Adaptive immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Golgi apparatus, Vesicles, Plasma membrane" "HPA001868: AB_2172440" "unprognostic (1.29e-2)" "unprognostic (3.04e-1)" "unprognostic (2.72e-2)" "unprognostic (9.72e-3)" "unprognostic (2.92e-1)" "unprognostic (1.74e-1)" "unprognostic (1.39e-1)" "unprognostic (3.54e-2)" "unprognostic (5.82e-2)" "unprognostic (3.23e-2)" "unprognostic (2.07e-2)" "unprognostic (3.28e-2)" "unprognostic (2.03e-3)" "unprognostic (4.42e-2)" "unprognostic (2.29e-1)" "unprognostic (1.38e-1)" "unprognostic (9.97e-2)" 4.5 4.7 6.2 1.3 6.8 1.6 3.9 5.2 6.5 4.8 2.9 3.6 1.1 4.4 1.0 2.0 4.2 1.8 3.1 4.7 4.4 6.7 1.0 34.6 1.3 5.4 4.9 6.2 3.8 5.9 1.5 5.1 6.7 4.6 0.7 0.8 3.8 3.5 4.9 3.2 2.2 2.0 4.9 2.0 3.7 1.6 5.7 0.7 9.6 5.5 0.8 4.3 3.1 4.1 1.6 2.6 2.1 2.7 1.3 4.4 2.6 1.4 1.5 1.9 1.4 1.0 1.7 0.5 1.6 1.3 1.2 0.9 1.0 0.6 0.7 0.8 0.9 0.3 0.3 0.5 2.1 0.1 2.3 3.3 3.2 1.2 1.1 1.7 1.6 2.9 2.0 0.5 1.0 2.2 1.0 0.6 0.6 3.8 1.7 3.2 1.8 1.5 0.4 1.8 0.2 1.0 2.7 2.3 2.0 0.9 3.2 1.2 1.4 3.8 2.9 1.6 0.8 5.3 5.0 0.7 1.1 1.2 0.9 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 6.2 6.8 5.2 6.5 4.7 4.4 5.4 4.9 6.7 4.9 5.7 4.1 17.8 3.2 5.9 0.7 1.4 6.2 2.3 0.3 5.7 0.1 8.1 23.2 15.4 2.8 0.9 1.8 0.0 1.1 1.7 1.0 0.0 0.3 0.1 1.3 1.7 9.2 0.0 0.4 0.6 0.6 0.7 7.0 0.0 3.0 0.0 2.0 6.8 1.3 1.1 0.0 0.5 0.7 2.0 1.6 2.5 0.1 3.4 2.5 3.6 7.5 0.3 3.3 0.0 0.0 0.5 0.5 1.4 4.5 0.9 1.7 1.2 1.9 0.2 0.1 0.0 30.3 6.1 0.3 0.7 5.0 4.1 2.7 1.1 1.3 1.5 1.0 PSEN1 "AD3, FAD, PS1, S182" ENSG00000080815 "Presenilin 1" P49768 14 73136418-73223691 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Apoptosis, Cell adhesion, Notch signaling pathway" "Hydrolase, Protease" "Alzheimer disease, Amyloidosis, Cancer-related genes, Cardiomyopathy, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in all" 5 "Oligodendrocytes: 395.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB006844, HPA030760, HPA067496" Approved Supported "Nucleoplasm,Golgi apparatus,Cell Junctions" Yes No "Cluster 31: Non-specific - Inflammatory response" "Cluster 45: Intestine - Brush border" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Golgi apparatus" "Nucleoplasm, Cell Junctions" "CAB006844: , HPA030760: AB_10696211, HPA067496: AB_2685853" "unprognostic (1.67e-1)" "unprognostic (4.79e-2)" "unprognostic (7.39e-2)" "unprognostic (8.68e-3)" "unprognostic (3.84e-1)" "unprognostic (5.48e-3)" "prognostic unfavorable (1.99e-5)" "unprognostic (1.65e-1)" "unprognostic (8.99e-2)" "unprognostic (8.45e-2)" "unprognostic (1.76e-3)" "unprognostic (2.74e-1)" "prognostic favorable (1.52e-8)" "unprognostic (2.29e-1)" "unprognostic (2.32e-1)" "unprognostic (7.12e-3)" "unprognostic (1.85e-1)" 25.1 22.6 44.3 26.5 80.7 39.6 28.2 62.4 56.0 28.1 48.9 49.5 50.2 25.3 26.9 35.2 22.9 31.7 18.0 47.4 51.6 35.5 31.9 32.1 22.4 73.0 63.8 22.0 22.9 35.1 11.6 43.1 71.5 24.3 46.3 23.4 22.9 23.4 18.4 38.2 49.0 27.1 55.7 22.6 31.0 32.5 60.8 26.2 36.9 23.3 30.7 35.0 19.2 119.1 37.1 55.9 50.6 20.0 68.9 49.9 46.7 52.5 60.1 52.6 66.7 69.9 88.9 23.7 34.1 50.5 43.0 94.9 43.2 40.1 57.3 54.6 26.7 27.1 35.1 34.4 63.8 27.7 50.7 50.4 71.9 44.3 54.4 48.5 43.2 26.2 31.0 46.6 50.0 72.8 21.0 35.7 22.0 64.5 40.4 26.4 42.7 30.2 73.7 76.5 28.1 38.3 57.4 53.0 47.1 45.4 66.3 60.7 45.7 53.1 43.5 44.1 25.3 30.3 47.9 23.7 44.9 32.8 33.3 126.8 94.5 96.3 23.1 106.0 22.6 23.1 22.3 19.0 83.4 31.8 20.7 20.1 129.3 42.8 125.0 43.6 37.0 70.3 44.3 80.7 62.4 56.0 47.4 51.6 73.0 63.8 71.5 55.7 60.8 119.1 22.2 28.9 30.5 35.9 25.8 28.6 24.6 24.7 12.0 17.1 25.0 17.7 12.5 15.7 30.2 23.9 39.6 27.1 30.7 79.1 5.9 27.1 22.9 26.3 26.4 22.3 16.2 12.0 38.9 26.7 29.2 23.7 32.1 47.4 18.3 29.6 15.7 24.6 30.5 13.5 40.2 39.5 24.4 50.5 40.8 12.9 16.4 52.3 16.0 39.4 51.8 13.8 14.4 48.7 395.8 38.2 58.8 15.4 23.6 38.8 76.2 13.0 29.0 28.0 26.3 20.0 19.0 40.2 14.4 20.4 33.0 49.9 21.6 18.6 41.3 51.5 PSEN2 "AD3L, AD4, PS2, STM2" ENSG00000143801 "Presenilin 2" P49810 1 226870184-226927726 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Notch signaling pathway" "Hydrolase, Protease" "Alzheimer disease, Amyloidosis, Cardiomyopathy, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Ionocytes: 36.7;Syncytiotrophoblasts: 45.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 50: Non-specific - Ribosome" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 10: Non-specific - Unknown function" "unprognostic (3.40e-2)" "unprognostic (4.73e-3)" "unprognostic (2.94e-1)" "unprognostic (3.86e-2)" "unprognostic (6.54e-2)" "unprognostic (1.64e-3)" "unprognostic (4.72e-2)" "unprognostic (1.31e-1)" "unprognostic (9.98e-2)" "unprognostic (2.73e-2)" "unprognostic (8.25e-3)" "unprognostic (8.53e-3)" "unprognostic (8.45e-2)" "unprognostic (1.17e-1)" "unprognostic (8.36e-2)" "unprognostic (1.68e-1)" "unprognostic (1.06e-1)" 11.2 19.8 9.7 7.5 9.8 1.6 10.6 12.5 10.7 9.7 10.7 15.2 10.5 15.9 9.0 10.3 13.4 8.3 14.0 9.4 10.6 13.5 12.6 11.5 8.0 9.8 10.9 12.8 45.5 18.1 17.1 9.0 10.8 14.9 8.1 7.4 13.0 13.6 26.5 10.1 13.8 10.4 8.5 15.6 11.5 13.5 10.7 3.3 9.5 16.7 5.0 13.5 9.7 9.7 14.1 24.5 7.2 21.9 10.0 3.5 10.2 12.4 26.5 16.9 12.9 13.8 21.5 1.0 17.0 16.8 10.5 7.9 12.1 11.9 6.7 13.6 20.7 8.7 10.5 12.0 15.4 7.5 15.7 9.1 13.9 18.9 10.4 11.2 6.9 0.7 18.1 6.4 10.0 14.7 0.4 8.2 20.5 22.0 16.0 0.4 22.6 26.4 15.9 13.4 11.3 18.3 9.7 30.6 51.6 18.4 26.5 13.1 8.5 11.2 8.9 9.9 15.2 25.6 45.0 0.9 21.5 2.5 15.7 37.4 8.7 18.4 4.5 9.7 5.1 7.4 1.5 4.6 11.4 3.1 0.7 2.0 1.6 20.0 30.2 0.8 2.4 5.2 9.7 9.8 12.5 10.7 9.4 10.6 9.8 10.9 10.8 8.5 10.7 9.7 11.0 16.0 10.8 2.6 3.9 1.7 4.5 4.0 1.8 6.2 6.6 4.1 12.9 15.7 4.7 5.5 0.0 15.9 1.3 5.9 1.9 13.0 2.5 4.5 3.0 10.0 6.0 6.1 4.2 18.0 4.1 5.9 7.7 5.2 14.5 10.1 19.2 8.4 17.2 16.8 4.5 5.1 36.7 7.2 6.5 1.3 7.2 8.2 33.8 5.6 18.9 21.2 2.1 2.5 1.5 15.2 7.8 13.2 9.9 5.3 13.8 7.2 4.9 5.8 6.6 9.4 10.6 1.5 6.1 3.8 1.8 45.8 2.9 6.6 4.3 4.6 PTPRQ DFNB84 ENSG00000139304 "Protein tyrosine phosphatase receptor type Q" 12 80402178-80680273 "Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in some" "kidney: 7.1;urinary bladder: 4.1" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 16.0;Club cells: 4.4;Early spermatids: 10.9;Excitatory neurons: 11.2;Late spermatids: 4.6" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC TERT1: 4.9;BJ: 3.9;HBF TERT88: 2.6;RH-30: 2.9;RT4: 3.4;SiHa: 1.9;U-2197: 3.2" "Not detected" "Not detected" "Not detected" "Not detected" HPA053245 Uncertain Approved Cytosol No NA "Cluster 7: Kidney - Transmembrane transport" "Cluster 18: U-2197 - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "HPA053245: AB_2682087" "unprognostic (9.10e-2)" "unprognostic (1.63e-1)" "unprognostic (1.15e-1)" "unprognostic (3.30e-2)" "unprognostic (1.37e-1)" "unprognostic (1.93e-2)" "unprognostic (1.04e-2)" "unprognostic (1.46e-1)" "unprognostic (1.80e-2)" "unprognostic (1.78e-1)" "unprognostic (4.47e-11)" "unprognostic (8.51e-3)" "unprognostic (1.47e-1)" "unprognostic (1.73e-2)" "unprognostic (2.66e-2)" 3.2 0.0 0.3 0.0 2.0 0.0 0.4 0.0 0.7 0.5 0.0 0.1 0.0 0.0 1.9 0.1 1.6 0.2 1.1 0.2 0.4 7.1 0.0 2.3 0.9 1.0 0.7 0.3 0.3 0.1 0.1 0.1 0.6 0.6 0.0 0.8 0.1 0.1 0.2 0.1 0.0 0.0 0.8 0.0 0.1 2.7 0.3 0.2 2.9 0.0 0.3 4.1 0.3 0.0 0.0 0.0 0.0 0.0 0.1 4.9 0.0 3.9 0.8 1.2 0.7 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.7 0.0 0.2 0.0 0.0 0.5 0.0 0.5 0.1 0.3 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.9 0.0 0.0 3.4 0.0 0.0 1.9 0.0 0.0 0.1 0.2 0.0 0.0 0.3 0.1 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 2.0 0.0 0.7 0.2 0.4 1.0 0.7 0.6 0.8 0.3 0.0 0.0 16.0 1.1 2.0 0.0 0.0 1.9 0.3 0.0 0.1 0.0 0.0 3.0 0.0 4.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.9 0.0 0.0 0.0 0.0 0.0 11.2 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 4.6 0.0 0.1 0.0 0.0 0.0 0.9 0.0 2.5 1.3 0.0 0.0 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 2.5 0.2 0.8 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.7 PUM1 "KIAA0099, PUMH1" ENSG00000134644 "Pumilio RNA binding family member 1" Q14671 1 30931506-31065991 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Differentiation, Spermatogenesis, Translation regulation" RNA-binding "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027424, HPA027449" Approved Enhanced Nucleoplasm,Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Cytosol Nucleoplasm "HPA027424: AB_10602918, HPA027449: AB_2672281" "unprognostic (1.26e-1)" "unprognostic (1.21e-1)" "unprognostic (1.44e-3)" "unprognostic (1.10e-1)" "unprognostic (1.31e-2)" "unprognostic (1.29e-1)" "prognostic unfavorable (3.73e-4)" "unprognostic (1.02e-1)" "unprognostic (2.11e-2)" "unprognostic (2.44e-2)" "unprognostic (3.19e-3)" "unprognostic (4.42e-2)" "prognostic favorable (7.62e-8)" "unprognostic (1.57e-1)" "unprognostic (5.41e-2)" "unprognostic (1.19e-1)" "unprognostic (2.74e-1)" 27.8 26.0 33.4 22.5 34.3 52.0 31.9 37.5 37.8 28.0 28.5 26.7 22.5 32.2 29.3 25.7 35.0 22.7 28.6 33.7 42.5 28.7 25.9 25.6 26.2 27.0 30.0 40.3 27.5 39.3 19.2 32.4 28.0 27.3 29.4 38.4 30.3 28.0 46.1 32.7 22.6 31.6 27.8 25.7 26.3 18.4 45.5 35.1 34.9 38.3 26.1 27.1 26.0 31.5 33.7 43.7 70.4 44.7 54.1 46.5 48.2 39.3 47.9 40.3 45.5 46.0 56.6 39.3 40.2 53.8 25.2 48.2 58.3 43.4 51.4 33.2 50.8 42.8 50.7 56.0 37.9 52.6 39.2 50.0 53.3 53.5 56.1 52.8 55.6 36.9 60.0 36.1 46.5 28.1 51.6 37.8 72.2 42.0 30.2 53.1 48.0 42.3 58.7 50.0 58.0 44.0 54.5 41.7 47.6 77.6 42.1 39.3 58.5 33.2 29.8 44.7 39.7 28.8 28.3 42.5 29.7 38.3 43.0 44.1 31.3 24.8 31.0 30.3 31.7 23.9 27.5 30.3 32.0 21.1 31.0 32.0 19.6 37.9 34.5 18.5 35.9 31.0 33.4 34.3 37.5 37.8 33.7 42.5 27.0 30.0 28.0 27.8 45.5 31.5 66.6 73.7 58.8 85.2 56.9 90.2 53.8 41.2 56.3 54.6 63.2 58.7 80.7 61.5 46.3 36.8 79.2 52.6 66.4 56.4 23.5 44.0 32.2 139.8 98.0 61.5 104.7 34.3 87.0 36.4 42.4 56.8 55.0 154.6 18.3 105.1 43.2 61.0 34.0 33.7 87.5 65.6 24.4 78.3 49.8 21.5 72.1 50.4 17.8 102.1 56.6 41.6 69.0 111.6 101.7 58.1 45.0 80.5 41.7 84.6 28.8 49.2 42.7 59.2 32.9 81.6 65.5 36.4 24.4 62.9 93.6 78.0 50.5 63.6 75.8 95.5 PXMP2 "MPV17L3, PMP22" ENSG00000176894 "Peroxisomal membrane protein 2" Q9NR77 12 132687587-132704985 "Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 312.0" "Cell type enhanced" "Detected in many" "Distal enterocytes: 187.3;Hepatocytes: 577.4;Proximal enterocytes: 333.3;Proximal tubular cells: 303.7" "Cancer enhanced" "Detected in all" "liver cancer: 43.8" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 85: Liver - Metabolism" "Cluster 14: REH - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "unprognostic (1.12e-2)" "unprognostic (7.96e-2)" "unprognostic (4.70e-3)" "unprognostic (1.14e-1)" "unprognostic (1.61e-1)" "prognostic unfavorable (9.84e-4)" "unprognostic (7.39e-3)" "unprognostic (2.83e-1)" "unprognostic (2.44e-2)" "unprognostic (3.02e-1)" "unprognostic (2.60e-1)" "unprognostic (1.88e-1)" "prognostic favorable (2.75e-4)" "unprognostic (9.89e-2)" "unprognostic (5.52e-2)" "unprognostic (3.71e-3)" "unprognostic (3.04e-1)" 24.8 14.7 23.7 7.5 24.3 23.4 18.7 24.5 29.8 14.3 37.7 49.5 52.1 14.9 22.3 16.2 18.7 15.4 62.9 28.5 24.1 58.2 312.0 12.9 11.5 24.1 24.2 23.0 42.5 14.5 9.3 8.1 22.9 19.8 39.2 7.5 18.6 9.7 42.3 16.8 55.1 9.5 23.0 13.1 98.2 9.1 24.9 25.9 14.7 30.5 10.7 15.9 12.8 23.5 60.5 24.8 36.6 34.1 21.5 16.6 21.4 21.0 19.4 44.7 39.6 30.3 22.4 37.2 24.9 30.0 15.7 42.0 49.1 26.6 24.3 21.3 77.8 33.2 43.9 33.8 41.7 24.8 14.4 21.7 21.8 18.6 14.7 31.2 12.1 56.2 58.2 28.4 23.8 54.2 78.9 39.2 35.7 70.0 33.9 80.1 39.2 30.6 32.9 25.2 69.0 22.5 45.6 23.6 29.6 28.1 63.2 56.0 14.3 21.9 51.1 19.1 35.6 25.7 26.7 60.6 24.6 34.9 17.7 0.0 1.2 2.9 2.3 0.6 2.1 2.5 1.8 2.4 2.1 2.7 1.8 1.5 0.7 1.5 0.6 6.3 3.1 1.2 23.7 24.3 24.5 29.8 28.5 24.1 24.1 24.2 22.9 23.0 24.9 23.5 10.9 3.2 7.2 8.1 8.2 8.4 20.0 10.6 15.4 6.1 50.3 51.1 35.8 138.7 6.0 25.8 4.2 60.1 7.3 187.3 166.3 16.5 18.7 11.8 16.9 14.1 18.7 55.9 5.9 10.3 36.6 17.0 65.7 17.4 4.5 32.4 46.8 577.4 34.9 0.0 7.1 85.1 2.0 19.2 9.4 38.8 31.1 8.1 12.4 5.6 2.7 45.5 13.4 4.5 1.0 10.2 143.4 35.0 20.9 28.1 333.3 303.7 2.1 7.3 19.7 7.5 14.8 44.9 30.2 31.2 10.7 28.5 8.1 12.4 158.6 23.2 RAB28 ENSG00000157869 "RAB28, member RAS oncogene family" P51157 4 13361354-13484365 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cone-rod dystrophy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 119.9;Inhibitory neurons: 140.4;Spermatocytes: 123.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044575 Approved NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 77: Retina - Visual perception" "Cluster 2: Karpas-707 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA044575: AB_10959460" "unprognostic (2.10e-1)" "unprognostic (1.95e-1)" "unprognostic (1.59e-2)" "unprognostic (1.81e-1)" "unprognostic (2.17e-1)" "unprognostic (2.46e-2)" "unprognostic (3.90e-2)" "unprognostic (1.04e-1)" "unprognostic (1.40e-1)" "unprognostic (3.69e-2)" "unprognostic (2.09e-2)" "unprognostic (1.07e-1)" "unprognostic (4.47e-2)" "unprognostic (1.09e-1)" "unprognostic (1.18e-1)" "unprognostic (5.31e-3)" "prognostic favorable (1.61e-4)" 17.1 18.9 22.9 12.8 25.2 19.3 20.3 39.5 29.2 15.3 24.9 16.2 11.0 22.5 18.8 12.0 21.9 15.5 30.4 23.7 29.5 16.4 11.9 16.1 18.3 22.3 26.7 22.4 10.0 23.9 19.3 19.5 24.7 16.2 18.1 55.4 12.1 16.0 7.2 19.9 11.3 17.3 24.3 17.2 14.5 37.7 29.6 18.4 19.5 13.3 16.7 13.2 13.3 28.9 22.0 11.4 36.3 18.6 18.7 34.8 19.0 19.7 22.7 21.7 28.9 11.3 22.7 26.0 12.5 19.3 46.0 11.1 31.4 17.6 39.3 16.7 15.7 18.6 20.1 10.8 18.3 21.2 10.9 16.0 23.3 19.8 18.7 26.5 23.9 32.9 37.0 97.1 30.4 8.8 45.3 52.7 50.7 16.4 19.9 28.6 22.8 21.5 18.7 11.9 28.7 17.3 17.0 12.2 28.1 28.2 13.7 23.8 16.5 28.8 12.6 23.8 30.7 24.0 18.0 34.6 25.7 38.3 38.6 21.0 16.2 26.1 16.5 15.6 17.0 18.4 15.3 16.2 16.8 17.9 20.3 16.5 15.1 20.6 14.4 12.9 17.2 10.6 22.9 25.2 39.5 29.2 23.7 29.5 22.3 26.7 24.7 24.3 29.6 28.9 17.8 6.4 6.4 81.0 22.3 27.4 26.7 38.7 22.2 31.0 15.6 14.0 18.2 2.8 16.7 7.3 33.3 23.3 15.1 7.9 19.6 12.9 19.1 19.6 17.7 18.4 10.3 9.9 119.9 14.2 22.7 27.5 11.7 8.2 5.1 12.4 12.8 6.8 17.0 32.0 140.4 11.0 32.6 15.1 18.2 20.6 18.6 14.2 30.2 49.6 16.7 44.5 19.6 97.0 79.8 11.2 7.8 24.0 19.2 21.4 6.3 18.8 36.5 44.1 19.7 24.1 20.1 123.9 63.7 20.6 30.0 27.9 21.3 10.6 11.6 19.0 RAB7A "CMT2B, RAB7" ENSG00000075785 "RAB7A, member RAS oncogene family" P51149 3 128693669-128825942 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Autophagy, Host-virus interaction, Lipid degradation, Lipid metabolism, Protein transport, Transport" Hydrolase "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006964, CAB037131" Supported Supported Lysosomes NA NA 5700000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 59: Non-specific - Translation" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 16: Pancreatic endocrine cells - Mixed function" Lysosomes "CAB037131: AB_477460, HPA006964: AB_1856015" "unprognostic (1.99e-2)" "unprognostic (9.03e-2)" "unprognostic (1.41e-2)" "prognostic unfavorable (1.52e-4)" "unprognostic (1.45e-1)" "unprognostic (7.82e-2)" "prognostic unfavorable (9.89e-6)" "unprognostic (2.15e-2)" "unprognostic (2.38e-1)" "unprognostic (3.50e-1)" "prognostic unfavorable (4.63e-4)" "unprognostic (4.69e-1)" "unprognostic (6.73e-3)" "unprognostic (1.88e-1)" "unprognostic (1.97e-1)" "unprognostic (3.03e-3)" "unprognostic (5.64e-3)" 170.6 157.1 120.1 101.4 132.2 99.9 149.5 133.4 159.4 138.3 123.7 128.9 108.3 137.4 143.0 188.2 110.1 109.7 186.8 128.9 138.4 131.8 145.2 152.9 108.8 138.8 142.0 122.7 88.6 155.9 101.5 117.5 139.4 101.3 126.0 103.8 133.3 63.9 332.4 164.9 116.8 124.0 135.9 123.0 114.9 61.5 140.3 124.6 122.5 249.7 136.6 144.4 143.4 159.0 280.2 95.5 146.0 78.3 300.6 94.0 126.0 252.8 183.9 164.4 158.8 170.1 179.2 134.2 163.2 236.2 289.9 163.4 175.2 248.6 99.2 149.4 111.7 294.3 83.6 165.8 303.0 269.4 182.5 243.7 104.0 176.7 204.4 220.7 89.2 114.4 143.4 148.0 108.1 213.1 176.8 294.6 121.4 294.8 144.8 140.2 130.7 170.4 85.7 205.4 105.8 138.5 142.1 194.7 405.4 174.9 180.3 254.8 202.9 192.7 98.0 325.7 125.9 184.4 187.0 192.0 312.7 212.1 235.5 194.9 176.8 213.6 92.1 192.3 92.3 93.2 97.4 94.5 200.0 85.8 94.8 93.6 374.2 128.8 204.0 81.8 120.7 201.3 120.1 132.2 133.4 159.4 128.9 138.4 138.8 142.0 139.4 135.9 140.3 159.0 154.4 89.8 81.8 66.9 109.9 296.7 331.2 218.1 104.7 66.0 112.8 73.0 110.7 90.1 129.4 132.4 18.8 230.0 92.3 222.1 240.7 259.6 11.2 90.8 90.8 165.3 96.9 111.3 83.9 198.9 283.4 172.5 79.0 142.4 146.2 46.5 142.8 127.9 403.9 74.0 82.5 122.8 219.7 208.6 379.9 19.6 133.6 242.8 339.7 99.3 220.9 154.6 121.5 80.9 111.4 303.7 185.0 157.2 79.9 279.2 172.7 332.3 118.7 37.6 138.1 107.7 160.5 116.4 100.4 122.8 308.0 497.9 107.7 109.6 103.5 324.6 RAD51 "BRCC5, FANCR, HsRad51, HsT16930, RAD51A, RECA" ENSG00000051180 "RAD51 recombinase" Q06609 15 40694774-40732340 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "DNA damage, DNA recombination, DNA repair" DNA-binding "Cancer-related genes, Disease variant, Fanconi anemia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 15.7;testis: 24.3" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 35.3;Extravillous trophoblasts: 67.2;Spermatocytes: 53.6;Spermatogonia: 24.8;Syncytiotrophoblasts: 25.3" "Cancer enhanced" "Detected in all" "testis cancer: 19.9" "Low region specificity" "Detected in single" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "CAB010381, HPA039310" Enhanced Supported "Nucleoli rim,Cytosol" NA Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "Nucleoli rim" Cytosol "CAB010381: AB_2253533, HPA039310: AB_2676434" "prognostic unfavorable (7.94e-4)" "unprognostic (7.20e-3)" "unprognostic (1.22e-1)" "unprognostic (2.72e-2)" "unprognostic (8.23e-2)" "unprognostic (1.37e-1)" "prognostic unfavorable (9.33e-4)" "unprognostic (3.40e-3)" "unprognostic (2.53e-2)" "unprognostic (1.76e-1)" "unprognostic (1.41e-3)" "unprognostic (2.53e-3)" "unprognostic (0.00e+0)" "unprognostic (2.26e-2)" "unprognostic (2.34e-1)" "unprognostic (9.59e-2)" "unprognostic (1.94e-2)" 0.9 0.6 0.4 5.5 0.5 10.5 1.9 1.7 0.7 1.0 0.6 8.3 3.2 1.2 0.4 4.2 0.7 1.3 0.6 0.4 0.5 0.5 1.3 1.1 11.0 0.4 0.3 0.6 1.4 0.5 0.2 6.8 0.5 0.8 9.1 0.3 1.0 0.3 1.0 3.1 4.1 2.4 0.1 2.4 1.8 24.3 0.3 15.7 0.6 0.5 13.3 1.7 1.5 0.5 33.8 16.1 33.4 16.3 4.4 7.8 31.1 54.9 16.5 43.3 43.8 35.4 22.1 20.4 26.8 20.9 18.9 67.7 56.6 22.1 42.3 39.0 22.2 47.7 28.2 30.4 0.4 37.9 28.5 1.7 2.9 30.0 13.5 6.4 22.5 48.5 59.6 55.8 36.6 28.5 54.4 43.6 35.2 69.2 19.0 61.0 49.0 30.7 15.4 45.3 15.4 27.0 23.6 41.4 8.5 39.2 27.0 39.4 9.9 32.8 22.2 48.7 27.2 12.0 65.1 59.8 16.3 78.0 33.5 1.3 0.6 1.7 2.4 1.3 0.6 1.7 2.5 3.2 1.0 1.1 0.6 1.2 1.2 1.8 1.4 0.9 5.9 1.2 0.4 0.5 1.7 0.7 0.4 0.5 0.4 0.3 0.5 0.1 0.3 0.5 0.0 0.0 0.0 0.3 1.9 3.6 1.5 2.0 0.0 0.8 0.1 0.0 0.9 0.0 1.0 0.0 0.0 35.3 1.4 3.0 0.0 0.0 5.7 0.2 0.2 1.0 0.0 16.0 1.6 0.0 67.2 1.3 2.0 0.2 0.0 0.6 2.2 0.2 12.7 0.0 1.2 5.3 2.0 1.6 1.7 5.3 0.6 0.5 0.0 1.0 0.3 0.3 2.1 0.5 0.6 0.1 5.0 0.7 8.2 0.9 1.0 0.0 0.1 0.0 0.0 0.5 0.9 53.6 24.8 3.9 1.6 25.3 1.2 0.1 8.0 2.1 RAPGEF2 "DKFZP586O1422, KIAA0313, PDZ-GEF1, PDZGEF1, RA-GEF" ENSG00000109756 "Rap guanine nucleotide exchange factor 2" Q9Y4G8 4 159103013-159360174 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Differentiation, Neurogenesis" "Developmental protein, GTPase activation, Guanine-nucleotide releasing factor" Epilepsy "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 456.2;Inhibitory neurons: 264.1;Microglial cells: 238.9;Oligodendrocyte precursor cells: 199.0;Oligodendrocytes: 236.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "neutrophil: 5.9" "Group enriched" "Detected in many" 5 "granulocytes: 5.9;NK-cells: 3.3" "Cell line enhanced" "Detected in many" "HMC-1: 104.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA068798 Supported "Plasma membrane,Cytosol" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane, Cytosol" "HPA068798: " "unprognostic (4.88e-2)" "unprognostic (7.42e-2)" "unprognostic (1.67e-2)" "unprognostic (7.79e-3)" "unprognostic (8.16e-2)" "unprognostic (4.71e-3)" "unprognostic (4.20e-3)" "unprognostic (2.33e-1)" "unprognostic (2.17e-1)" "unprognostic (2.65e-2)" "unprognostic (9.71e-2)" "unprognostic (1.07e-1)" "prognostic favorable (1.76e-7)" "unprognostic (2.29e-1)" "unprognostic (2.07e-1)" "unprognostic (2.01e-2)" "unprognostic (1.78e-1)" 22.7 9.4 8.7 13.4 19.8 87.5 24.1 4.1 32.1 16.7 0.0 21.8 15.9 16.1 9.8 13.8 14.0 20.1 23.2 27.4 0.3 22.7 30.5 26.6 11.9 0.0 0.7 13.5 19.5 23.5 15.3 38.5 0.3 12.2 20.8 35.1 25.3 12.6 21.7 17.5 17.0 19.7 0.6 29.7 19.3 9.8 6.0 17.5 39.5 31.4 11.5 14.8 11.8 18.6 8.9 11.9 55.4 17.2 21.4 23.9 84.9 17.0 21.3 15.2 10.9 36.7 19.4 50.7 6.1 17.0 22.0 8.0 19.1 21.8 18.0 8.6 13.2 79.0 25.3 21.4 15.5 9.7 104.5 14.1 12.1 36.5 12.9 32.0 44.1 20.7 17.6 46.0 19.0 15.6 24.1 1.5 23.7 10.4 11.8 19.7 14.0 2.0 13.6 20.2 15.7 21.0 24.9 12.1 20.0 26.5 6.0 6.3 47.0 23.9 25.2 30.7 14.2 51.0 32.9 0.8 28.3 4.1 14.8 2.2 1.0 0.7 0.5 0.5 0.6 0.2 0.4 0.3 0.5 0.2 0.6 0.3 5.9 3.3 0.6 1.0 1.0 0.3 8.7 19.8 4.1 32.1 27.4 0.3 0.0 0.7 0.3 0.6 6.0 18.6 66.7 57.7 30.1 110.7 12.9 20.4 11.2 7.5 9.6 19.7 23.5 11.9 39.0 11.5 13.8 7.3 41.7 11.1 20.2 24.8 0.0 9.2 5.3 43.5 19.5 49.2 14.4 38.9 456.2 12.6 9.6 16.9 7.7 59.2 51.8 22.9 32.2 30.5 10.8 33.7 264.1 12.0 2.0 24.6 20.1 5.3 7.8 29.5 33.8 238.9 15.6 30.2 2.1 199.0 236.2 22.1 17.7 8.6 40.5 17.6 7.1 8.7 18.7 22.4 52.6 28.1 37.2 3.5 8.9 10.7 20.0 5.9 12.9 7.2 7.9 15.1 RAPSN "CMS1D, CMS1E, RNF205" ENSG00000165917 "Receptor associated protein of the synapse" Q13702 11 47437764-47449143 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 23 "skeletal muscle: 88.9;tongue: 33.1" "Cell type enriched" "Detected in some" 4 "Skeletal myocytes: 63.8" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "RH-30: 238.7" "Low region specificity" "Detected in some" HPA039475 Approved Approved "Plasma membrane,Centrosome,Cytosol" NA NA "Cluster 33: Striated muscle - Muscle contraction" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane, Centrosome, Cytosol" "HPA039475: AB_10794196" "unprognostic (5.37e-2)" "unprognostic (1.02e-1)" "unprognostic (7.34e-2)" "unprognostic (4.58e-2)" "unprognostic (2.95e-2)" "unprognostic (1.44e-1)" "unprognostic (2.62e-2)" "unprognostic (1.77e-3)" "unprognostic (1.35e-1)" "unprognostic (5.38e-2)" "unprognostic (4.81e-2)" "unprognostic (2.89e-2)" "unprognostic (1.08e-2)" "unprognostic (1.64e-4)" "unprognostic (3.83e-1)" "unprognostic (4.73e-3)" "unprognostic (4.48e-2)" 0.3 1.5 0.5 0.2 0.5 0.3 0.2 0.3 1.2 0.2 0.9 0.8 0.1 0.0 0.1 1.2 0.1 0.1 2.6 0.5 0.5 0.3 0.5 0.4 0.2 0.3 0.5 0.0 0.2 0.0 0.1 2.1 0.5 0.7 0.0 0.1 1.3 0.0 88.9 0.5 0.5 0.1 0.4 0.6 0.2 0.3 0.6 0.1 0.2 33.1 0.1 0.1 0.1 0.5 0.0 0.2 0.0 0.3 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.2 0.3 0.2 0.7 0.1 0.2 1.2 4.7 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 59.6 0.0 0.0 0.2 0.0 0.0 0.2 0.0 238.7 0.0 0.3 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.3 0.1 0.3 0.1 0.3 0.3 0.3 0.1 0.1 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.5 0.5 0.3 1.2 0.5 0.5 0.3 0.5 0.5 0.4 0.6 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.3 0.0 0.0 0.3 0.3 1.4 0.0 0.8 0.0 0.0 0.0 0.3 0.0 0.0 0.5 2.7 0.3 0.1 0.2 0.0 0.0 0.1 0.2 0.1 1.0 0.0 0.5 0.0 0.2 0.0 0.8 0.2 0.0 0.0 0.0 0.0 0.3 0.3 13.8 0.0 0.5 0.0 0.0 0.6 1.3 0.0 0.5 0.0 0.8 0.0 0.0 0.1 0.2 0.0 0.0 1.1 0.0 0.0 63.8 0.5 0.0 0.4 0.0 0.0 0.3 0.4 0.1 0.2 0.1 RAX2 "ARMD6, CORD11, MGC15631, RAXL1" ENSG00000173976 "Retina and anterior neural fold homeobox 2" Q96IS3 19 3769089-3772228 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Sensory transduction, Transcription, Transcription regulation, Vision" DNA-binding "Age-related macular degeneration, Cone-rod dystrophy, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 40 "retina: 64.5" "Group enriched" "Detected in some" 9 "Cone photoreceptor cells: 123.0;Rod photoreceptor cells: 217.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" HPA052533 Uncertain Approved "Nucleoplasm,Nuclear speckles,Cytosol" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 46: Photoreceptor cells - Phototransduction" "Nuclear speckles" "Nucleoplasm, Cytosol" "HPA052533: AB_2681862" "unprognostic (5.53e-2)" "unprognostic (1.39e-2)" "unprognostic (4.48e-1)" 0.0 0.0 0.2 0.1 0.4 0.4 0.0 0.6 0.6 0.0 0.2 0.0 0.0 0.2 0.1 0.0 0.4 0.0 0.0 0.4 0.3 0.0 0.0 0.0 0.1 0.3 0.3 0.0 0.0 0.3 1.6 0.0 0.4 0.0 0.0 64.5 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.2 0.4 0.6 0.6 0.4 0.3 0.3 0.3 0.4 0.0 0.4 0.7 0.1 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 14.3 0.0 0.1 0.6 0.0 0.0 0.0 123.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 11.8 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 18.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 217.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 RBP3 "D10S64, D10S65, D10S66, RP66" ENSG00000265203 "Retinol binding protein 3" P10745 10 47348363-47357881 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted secreted proteins" Transport "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 335 "retina: 542.3" "Group enriched" "Detected in some" 11 "Cone photoreceptor cells: 2070.4;Rod photoreceptor cells: 1610.0" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enhanced" "Detected in single" "hippocampal formation: 1.3" "Low region specificity" "Detected in many" "HPA041301, HPA044239" Enhanced "Secreted in other tissues" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA041301: AB_2677398, HPA044239: AB_2678868" "unprognostic (3.48e-2)" "unprognostic (4.78e-3)" "unprognostic (1.36e-2)" "unprognostic (4.02e-2)" "unprognostic (1.40e-1)" "unprognostic (1.58e-2)" "unprognostic (5.09e-2)" "unprognostic (5.14e-3)" "unprognostic (7.44e-2)" "unprognostic (1.23e-1)" "unprognostic (4.68e-3)" 0.0 0.0 0.3 0.0 0.4 0.0 0.0 0.1 0.3 0.0 0.9 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 1.2 1.6 0.0 0.0 0.0 0.0 0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 542.3 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.1 0.3 1.2 1.6 0.5 0.3 0.6 0.1 0.4 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 157.7 0.0 0.0 0.5 0.0 0.0 0.0 2070.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 43.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 148.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1610.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 RD3 "C1orf36, LCA12" ENSG00000198570 "Retinal degeneration 3, GUCY2D regulator" Q7Z3Z2 1 211476522-211492162 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Sensory transduction, Vision" "Leber congenital amaurosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 54 "retina: 47.2" "Group enriched" "Detected in some" 10 "Bipolar cells: 82.7;Cone photoreceptor cells: 100.1;Rod photoreceptor cells: 66.4" "Cancer enhanced" "Detected in single" "testis cancer: 0.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HEL: 4.6;HMC-1: 14.4;SH-SY5Y: 21.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA029941, HPA029943" Enhanced NA NA "Cluster 79: Retina - Phototransduction" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 9: Photoreceptor cells - Phototransduction" "HPA029941: AB_2732449, HPA029943: AB_2732450" "unprognostic (1.42e-1)" "unprognostic (2.75e-2)" "unprognostic (1.14e-2)" "unprognostic (6.07e-2)" "unprognostic (2.96e-2)" "unprognostic (2.18e-1)" "unprognostic (9.54e-2)" "unprognostic (7.87e-2)" "unprognostic (1.15e-1)" "unprognostic (4.80e-2)" "unprognostic (4.58e-2)" "unprognostic (2.86e-2)" 0.0 0.7 0.1 0.0 0.2 0.2 0.0 0.5 0.3 0.2 0.8 0.0 0.1 0.1 0.7 0.1 0.0 0.1 0.0 0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 47.2 0.0 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.1 0.0 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.6 0.0 0.0 0.0 0.1 14.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.1 0.7 21.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.5 0.3 0.1 0.7 0.0 0.1 0.0 0.0 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 82.7 0.0 0.0 0.5 0.0 0.0 0.0 100.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 66.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 RDH12 "FLJ30273, LCA13, RP53, SDR7C2" ENSG00000139988 "Retinol dehydrogenase 12" Q96NR8 14 67701886-67734451 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Sensory transduction, Vision" Oxidoreductase "Disease variant, Leber congenital amaurosis, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "retina: 222.7;skin 1: 63.8" "Group enriched" "Detected in some" 5 "Cone photoreceptor cells: 146.0;Rod photoreceptor cells: 453.2" "Cancer enhanced" "Detected in many" "head and neck cancer: 5.6" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "Intracellular and membrane" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 46: Photoreceptor cells - Phototransduction" "unprognostic (4.25e-3)" "unprognostic (4.50e-3)" "unprognostic (1.16e-1)" "unprognostic (7.53e-2)" "unprognostic (2.99e-1)" "unprognostic (1.99e-1)" "unprognostic (6.70e-2)" "unprognostic (2.13e-1)" "unprognostic (1.69e-2)" "unprognostic (2.72e-3)" "unprognostic (7.59e-2)" "unprognostic (2.02e-1)" "unprognostic (1.42e-2)" "unprognostic (6.47e-2)" "unprognostic (7.83e-2)" "unprognostic (3.58e-1)" "unprognostic (3.92e-1)" 0.1 4.1 1.3 0.1 1.0 0.1 2.2 1.0 1.4 11.0 0.4 0.0 0.3 0.0 8.7 22.1 0.5 17.6 0.0 0.9 1.2 13.6 3.8 0.1 0.0 1.2 2.3 0.0 3.2 0.0 0.9 0.1 1.2 0.5 0.0 222.7 1.7 0.1 0.1 63.8 0.1 0.0 0.6 0.0 12.4 0.1 4.6 0.4 1.2 0.0 1.6 0.0 23.6 1.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.5 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.4 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.4 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 1.0 1.0 1.4 0.9 1.2 1.2 2.3 1.2 0.6 4.6 1.1 0.0 0.0 0.0 0.7 0.0 4.7 0.3 0.0 0.6 39.8 0.1 0.1 0.0 20.0 0.3 1.8 146.0 0.0 0.0 0.1 0.0 0.7 0.2 1.8 1.1 2.2 0.0 0.0 1.2 1.7 0.0 0.4 14.3 1.7 0.0 0.0 0.0 5.7 0.2 20.2 0.9 0.0 0.0 0.6 0.9 0.0 0.3 0.2 1.8 1.0 0.0 53.0 0.0 1.5 0.2 1.5 2.6 0.0 0.0 0.3 0.1 12.5 0.2 453.2 0.0 0.0 0.2 0.0 0.1 4.7 38.6 0.0 0.1 0.1 0.1 0.3 RDH5 "HSD17B9, RDH1, SDR9C5" ENSG00000135437 "Retinol dehydrogenase 5" Q92781 12 55720367-55724705 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Lipid metabolism, Sensory transduction, Steroid metabolism, Vision" Oxidoreductase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 94.5;liver: 58.9" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 62.6;Proximal enterocytes: 49.9;Rod photoreceptor cells: 62.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 28.5;ASC TERT1: 24.3;hTEC/SVTERT24-B: 15.3;hTERT-RPE1: 24.5;LHCN-M2: 15.4;U-87 MG: 26.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063345 Uncertain Vesicles "Intracellular and membrane" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 45: Enterocytes - Digestion" Vesicles "HPA063345: AB_2684992" "unprognostic (1.04e-2)" "unprognostic (6.45e-2)" "unprognostic (1.80e-1)" "unprognostic (2.67e-1)" "unprognostic (3.66e-2)" "unprognostic (1.48e-2)" "unprognostic (1.88e-2)" "unprognostic (1.54e-1)" "unprognostic (5.35e-2)" "unprognostic (4.04e-2)" "unprognostic (4.05e-1)" "unprognostic (1.26e-3)" "unprognostic (7.63e-2)" "unprognostic (8.79e-2)" "unprognostic (3.46e-2)" "unprognostic (2.12e-3)" "unprognostic (3.27e-2)" 94.5 1.8 2.2 4.1 2.5 1.0 34.2 2.2 2.6 2.5 3.5 13.6 18.5 4.2 7.8 3.1 4.6 4.2 9.2 2.0 2.2 9.0 58.9 1.9 1.8 2.7 2.5 2.1 3.5 0.3 1.7 0.6 2.4 4.4 4.4 3.2 3.3 2.2 6.1 2.7 15.5 19.5 2.5 2.2 5.9 2.4 2.8 0.9 2.7 7.6 0.7 5.5 2.2 3.4 0.7 1.4 0.8 0.5 28.5 24.3 0.6 3.8 4.2 0.7 1.4 0.5 7.9 1.0 0.7 2.1 0.2 0.3 0.3 0.1 0.6 1.0 1.3 0.1 2.0 2.1 0.8 0.1 0.3 10.5 1.0 15.3 0.1 24.5 0.3 0.5 0.2 1.3 15.4 0.7 0.4 0.2 0.3 3.7 2.3 0.6 0.4 0.5 0.2 0.8 0.2 1.1 0.2 0.5 3.4 0.2 0.7 0.6 0.5 1.5 1.5 1.1 0.9 1.1 0.5 0.2 26.7 0.4 0.3 0.0 0.1 0.5 0.0 0.1 0.0 0.1 0.2 0.5 0.2 0.0 0.2 0.0 0.2 0.3 0.2 0.5 0.0 0.0 2.2 2.5 2.2 2.6 2.0 2.2 2.7 2.5 2.4 2.5 2.8 3.4 2.5 9.6 2.2 0.0 4.6 1.9 4.5 3.9 0.6 24.3 2.7 5.0 3.9 10.0 2.4 1.8 62.6 2.2 5.3 23.5 1.9 2.1 0.8 1.8 2.9 3.7 11.5 0.0 0.0 2.6 1.2 3.9 11.2 1.5 0.0 4.9 3.6 18.4 0.6 16.8 0.0 10.3 0.0 4.5 7.9 2.3 13.4 2.3 5.4 0.0 4.7 8.2 12.3 0.0 0.0 3.6 18.6 6.8 0.7 3.2 49.9 13.0 4.7 62.9 13.1 14.0 9.3 3.9 6.4 0.8 1.7 1.5 4.8 5.3 15.9 3.1 RDX DFNB24 ENSG00000137710 Radixin P35241 11 109864295-110296712 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Actin capping, Actin-binding" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 155.0" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 484.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000263, HPA000763, CAB037312" Enhanced Supported "Nucleoplasm,Plasma membrane" NA NA 38000000 "Cluster 2: Granulocytes - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 1: Pancreatic cells - Digestion" "Plasma membrane" Nucleoplasm "CAB037312: AB_261933, HPA000263: AB_1856043, HPA000763: AB_1856042" "unprognostic (2.23e-3)" "unprognostic (2.56e-2)" "unprognostic (3.85e-1)" "unprognostic (2.74e-2)" "unprognostic (6.93e-2)" "unprognostic (9.82e-2)" "unprognostic (2.01e-2)" "unprognostic (1.44e-2)" "unprognostic (3.91e-2)" "unprognostic (6.91e-2)" "unprognostic (1.32e-3)" "unprognostic (6.47e-2)" "unprognostic (4.14e-3)" "unprognostic (5.43e-2)" "unprognostic (4.40e-1)" "unprognostic (1.24e-1)" "unprognostic (1.08e-3)" 40.3 155.0 38.0 17.4 57.7 12.0 16.4 50.0 42.7 32.1 32.8 15.2 6.8 28.8 12.9 27.4 19.7 27.2 41.0 35.1 44.7 50.2 68.5 48.8 11.4 52.7 48.2 52.8 52.7 33.2 7.6 35.3 54.3 25.4 11.1 19.2 20.8 26.0 82.1 11.9 7.4 35.0 45.1 26.6 15.0 33.7 47.7 14.3 45.7 59.7 14.6 27.1 10.1 77.6 69.6 35.3 137.3 54.8 78.8 87.4 79.3 85.8 47.6 54.3 59.2 99.7 115.4 0.1 127.4 104.7 84.9 61.5 77.3 80.4 80.5 41.9 44.2 51.5 107.7 74.1 73.6 19.0 33.2 89.7 45.6 68.0 120.1 89.3 149.8 11.1 73.5 29.5 127.0 120.0 11.0 15.6 44.0 4.0 58.4 31.2 96.8 30.1 68.1 33.5 37.2 40.5 148.5 65.9 52.7 102.5 85.0 29.9 92.6 89.5 66.8 43.9 67.4 9.5 17.3 65.9 34.2 11.3 210.9 29.5 14.8 22.0 11.6 12.5 15.5 11.5 10.2 8.8 12.8 8.3 6.8 5.8 2.0 17.6 9.9 10.3 22.0 8.4 38.0 57.7 50.0 42.7 35.1 44.7 52.7 48.2 54.3 45.1 47.7 77.6 248.8 484.0 98.8 53.5 30.0 56.1 51.8 124.6 56.9 85.9 47.4 45.7 159.3 70.1 77.9 75.4 43.8 122.1 21.6 17.7 109.5 128.1 15.5 109.1 117.2 289.2 22.2 104.8 27.1 423.4 189.8 88.4 19.9 135.3 67.2 132.0 319.2 260.1 85.1 101.0 57.6 7.3 61.1 103.2 59.9 43.6 275.2 71.6 72.9 42.2 135.4 77.0 36.0 68.3 229.4 134.3 22.1 266.7 36.1 65.9 0.1 236.9 52.2 94.8 124.9 74.0 143.8 73.9 257.4 52.8 40.5 227.3 29.2 229.9 11.8 45.9 REEP1 "C2orf23, FLJ13110, SPG31, Yip2a" ENSG00000068615 "Receptor accessory protein 1" Q9H902 2 86213993-86338083 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 50.0" "Cell type enhanced" "Detected in many" "Excitatory neurons: 86.2;Inhibitory neurons: 95.5;Oligodendrocyte precursor cells: 39.2" "Cancer enhanced" "Detected in many" "glioma: 7.1" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 68.1;HAP1: 15.0;RPMI-8226: 16.0;SCLC-21H: 32.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA058061 Enhanced NA NA "Cluster 49: Ciliated cells - Cilium organization" "Cluster 28: BEWO - Transcription regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA058061: AB_2683591" "unprognostic (1.94e-2)" "unprognostic (1.61e-3)" "unprognostic (2.03e-2)" "unprognostic (2.60e-1)" "unprognostic (2.29e-2)" "unprognostic (5.10e-2)" "unprognostic (6.63e-2)" "unprognostic (9.07e-2)" "unprognostic (1.53e-1)" "unprognostic (1.21e-1)" "unprognostic (6.15e-2)" "unprognostic (2.35e-1)" "unprognostic (2.56e-2)" "unprognostic (6.77e-2)" "unprognostic (2.94e-2)" "unprognostic (1.19e-1)" "unprognostic (1.07e-3)" 4.7 6.2 17.0 1.8 15.8 0.0 4.9 4.1 30.4 3.9 11.5 42.4 4.4 18.9 3.7 6.2 13.6 3.8 16.6 15.4 44.0 2.0 1.1 3.6 0.5 24.6 38.1 1.9 9.9 7.9 13.9 2.2 50.0 7.3 5.0 12.9 1.6 12.9 19.8 2.0 9.3 20.7 4.4 2.0 8.8 44.5 18.7 0.3 2.0 14.3 0.6 21.7 5.8 14.3 0.0 0.0 2.2 2.9 0.1 0.0 68.1 0.0 0.0 4.5 0.5 2.5 0.0 0.0 3.2 0.0 3.4 4.9 15.0 0.1 3.9 0.0 8.1 0.0 5.0 0.4 0.0 0.3 0.4 0.7 0.1 0.1 0.0 0.0 0.0 3.0 0.0 0.0 0.1 2.7 0.1 0.0 2.6 0.1 0.0 0.1 6.5 16.0 0.3 0.3 32.0 3.1 3.5 1.6 0.2 1.3 5.1 0.9 0.0 0.0 2.3 1.3 6.3 7.2 5.0 0.0 0.3 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.0 15.8 4.1 30.4 15.4 44.0 24.6 38.1 50.0 4.4 18.7 14.3 1.7 9.6 0.5 14.7 0.2 2.0 0.3 0.3 0.0 10.0 3.6 1.1 23.0 2.8 2.8 0.0 2.1 2.4 0.0 0.4 1.9 3.5 18.0 17.1 0.3 5.7 4.8 0.0 86.2 6.2 26.6 2.4 0.0 0.7 0.0 0.8 12.5 0.2 0.9 3.3 95.5 0.2 8.2 0.8 1.6 14.4 2.5 0.4 1.8 6.5 0.6 13.4 0.0 39.2 6.0 6.5 0.0 3.4 0.0 1.6 0.0 5.1 16.6 15.8 19.7 4.2 13.5 4.0 2.7 0.5 1.1 6.6 0.2 0.0 0.5 0.4 REEP2 "C5orf19, SGC32445, SPG72, Yip2d" ENSG00000132563 "Receptor accessory protein 2" Q9BRK0 5 138439057-138446969 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 155.7;choroid plexus: 77.8;retina: 61.2" "Cell type enhanced" "Detected in many" "Bipolar cells: 47.3;Cone photoreceptor cells: 70.9;Excitatory neurons: 51.2;Horizontal cells: 48.8;Inhibitory neurons: 46.1;Muller glia cells: 29.8;Rod photoreceptor cells: 73.6" "Cancer enriched" "Detected in many" 9 "glioma: 31.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AN3-CA: 97.3;SCLC-21H: 40.5;SH-SY5Y: 46.1;U-87 MG: 36.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031813, HPA076571" Enhanced Supported Approved "Endoplasmic reticulum" NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 46: Photoreceptor cells - Phototransduction" "Endoplasmic reticulum" "HPA031813: AB_2674054, HPA076571: " "prognostic favorable (7.83e-5)" "unprognostic (1.11e-2)" "unprognostic (3.97e-6)" "unprognostic (3.70e-3)" "prognostic unfavorable (6.65e-4)" "unprognostic (5.43e-2)" "unprognostic (1.62e-2)" "unprognostic (1.04e-1)" "prognostic favorable (9.31e-4)" "unprognostic (5.93e-2)" "unprognostic (3.70e-3)" "unprognostic (9.78e-2)" "unprognostic (6.54e-3)" "unprognostic (7.54e-2)" "unprognostic (1.47e-3)" "unprognostic (6.19e-3)" "unprognostic (1.13e-3)" 4.6 9.5 106.7 2.5 102.5 0.3 3.0 93.5 155.7 3.6 77.8 18.8 1.8 7.0 1.4 4.4 3.6 2.6 24.8 110.3 110.7 1.9 0.2 0.8 0.4 134.6 109.1 4.0 2.0 1.8 54.5 0.6 136.4 8.6 2.2 61.2 1.8 8.0 16.6 2.4 4.3 12.6 77.5 0.4 7.6 6.2 130.6 1.9 1.2 5.7 0.5 8.7 4.6 104.7 0.6 7.4 27.6 97.3 3.9 10.5 0.0 8.4 3.8 11.4 12.9 5.3 1.0 0.1 1.5 10.5 0.2 0.6 26.1 5.4 8.6 3.1 23.7 0.0 1.8 12.6 9.8 0.1 0.1 3.2 0.3 6.4 0.5 19.9 2.3 27.6 0.1 6.9 3.6 4.4 2.7 1.8 17.2 0.0 0.3 9.7 2.6 0.0 2.1 0.0 40.5 46.1 2.9 0.1 7.5 7.0 2.6 0.9 0.2 6.6 6.6 6.4 15.9 18.1 12.3 0.8 36.8 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.7 0.0 106.7 102.5 93.5 155.7 110.3 110.7 134.6 109.1 136.4 77.5 130.6 104.7 17.0 0.0 0.0 18.9 0.1 0.6 1.0 1.6 2.2 47.3 0.7 3.3 9.8 0.0 0.2 1.8 70.9 0.0 0.3 0.0 0.0 0.0 1.1 0.4 0.3 5.6 4.8 0.4 51.2 0.0 0.0 3.7 0.0 0.1 0.0 1.5 0.7 0.0 0.1 48.8 46.1 0.0 0.0 0.0 0.7 5.0 0.0 0.3 0.0 2.8 0.1 29.8 0.0 19.1 5.7 0.1 0.0 2.6 1.3 0.4 3.6 0.3 0.6 73.6 0.0 7.6 2.9 0.3 9.1 0.0 0.4 0.0 0.8 0.1 0.1 0.2 REEP6 "C19orf32, DP1L1, FLJ25383, Yip2f" ENSG00000115255 "Receptor accessory protein 6" Q96HR9 19 1491166-1497927 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 217.5;liver: 398.0;testis: 283.9" "Cell type enhanced" "Detected in many" "Early spermatids: 559.1;Late spermatids: 3135.0;Proximal enterocytes: 898.7" "Cancer enhanced" "Detected in all" "liver cancer: 114.0" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "CACO-2: 57.9;Hep G2: 56.2;K-562: 155.7;T-47d: 121.4" "HPA003895, HPA048015" Enhanced Supported "Endoplasmic reticulum" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 45: Intestine - Brush border" "Cluster 1: K-562 - Erythropoiesis" "Cluster 25: Spermatids - Spermatogenesis" "Endoplasmic reticulum" "HPA003895: AB_1845723, HPA048015: AB_2680233" "unprognostic (1.21e-1)" "unprognostic (1.56e-1)" "unprognostic (7.76e-2)" "unprognostic (1.63e-3)" "unprognostic (3.24e-1)" "unprognostic (2.43e-2)" "unprognostic (1.92e-1)" "unprognostic (6.85e-2)" "unprognostic (7.38e-2)" "unprognostic (4.56e-1)" "unprognostic (1.49e-1)" "unprognostic (1.93e-1)" "unprognostic (1.40e-2)" "unprognostic (2.17e-1)" "unprognostic (8.08e-2)" "unprognostic (2.83e-1)" "unprognostic (5.38e-2)" 8.4 86.5 11.1 1.3 12.4 1.2 17.5 10.1 18.0 5.6 7.7 3.0 217.5 3.5 14.6 14.3 4.6 7.0 3.9 12.7 8.8 22.1 398.0 1.6 1.3 9.7 10.1 7.7 28.5 2.0 9.8 1.6 9.9 20.1 1.7 94.0 17.9 6.8 2.0 9.3 199.6 0.9 8.4 1.7 4.2 283.9 12.1 0.7 6.0 0.7 1.0 9.2 7.0 10.9 7.3 9.2 2.6 34.3 5.6 2.0 39.5 1.8 0.7 1.9 1.9 57.9 22.5 3.9 12.2 1.1 2.3 7.3 9.8 0.6 1.0 1.9 4.1 21.3 1.3 56.2 4.2 1.6 6.6 4.7 4.1 0.4 1.4 3.2 1.1 4.9 155.7 5.0 0.3 29.6 1.8 4.7 12.8 21.1 19.5 4.9 1.1 10.0 10.9 2.7 0.7 17.2 9.8 14.2 6.3 1.9 121.4 5.7 3.4 2.8 5.4 8.7 1.2 16.4 5.3 0.8 11.2 9.4 8.2 0.0 1.1 0.0 5.5 1.2 2.8 0.1 1.4 1.2 1.9 0.6 2.0 2.2 0.0 4.9 4.3 3.3 1.6 1.6 11.1 12.4 10.1 18.0 12.7 8.8 9.7 10.1 9.9 8.4 12.1 10.9 1.5 3.2 3.2 2.6 2.7 6.8 7.9 6.8 10.8 30.4 47.4 20.3 1.8 91.5 10.5 5.5 33.3 69.4 2.5 7.8 7.9 34.5 559.1 4.5 7.1 4.2 6.0 10.1 1.5 69.2 12.8 4.7 2.6 3.0 10.2 132.9 5.0 267.4 9.6 23.5 1.2 51.9 4.1 6.3 4.3 3135.0 34.2 4.1 30.2 0.0 1.7 44.2 2.1 0.0 1.5 25.0 53.6 16.6 1.9 13.1 898.7 52.0 8.3 292.8 19.7 0.8 3.3 29.9 36.5 17.5 6.7 36.0 4.3 50.1 70.7 14.7 RELN "PRO1598, RL" ENSG00000189056 Reelin P78509 7 103471381-103989658 "Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Cell adhesion" "Developmental protein, Hydrolase, Protease, Serine protease" "Disease variant, Epilepsy, Lissencephaly" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "brain: 64.4" "Group enriched" "Detected in some" 8 "Hepatic stellate cells: 128.5;Inhibitory neurons: 372.4" "Cancer enhanced" "Detected in many" "liver cancer: 5.7" "Region enriched" "Detected in many" 10 "cerebellum: 64.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "Hep G2: 16.2;PC-3: 8.6;SCLC-21H: 11.1;SH-SY5Y: 13.7;TIME: 33.0" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebellum: 110.0" HPA077891 Approved "Golgi apparatus,Vesicles" "Secreted in brain" NA NA 30000000 "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Golgi apparatus" Vesicles "HPA077891: " "unprognostic (1.42e-1)" "unprognostic (2.93e-3)" "unprognostic (4.31e-2)" "unprognostic (1.29e-4)" "unprognostic (1.30e-1)" "unprognostic (6.95e-2)" "unprognostic (1.85e-1)" "unprognostic (8.35e-2)" "unprognostic (1.54e-1)" "unprognostic (1.48e-2)" "unprognostic (3.31e-3)" "unprognostic (3.86e-1)" "unprognostic (2.02e-2)" "unprognostic (1.43e-2)" "unprognostic (3.03e-1)" "unprognostic (1.35e-1)" "unprognostic (3.06e-2)" 1.3 1.8 2.0 0.6 1.8 0.0 2.7 64.4 3.8 1.5 0.6 0.8 0.2 0.4 0.1 0.8 2.8 0.7 1.7 3.3 6.4 0.4 13.4 0.5 0.4 2.6 4.2 0.4 0.1 0.0 0.5 0.0 6.3 0.6 0.9 2.9 0.8 0.9 0.2 0.6 0.9 0.7 3.9 0.3 0.5 0.7 0.5 0.0 1.7 1.1 0.2 0.7 0.7 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.3 0.0 0.0 0.0 0.0 0.0 5.8 0.0 0.0 2.1 0.0 0.1 0.0 0.0 4.3 0.0 16.2 0.0 0.0 0.0 0.0 0.0 0.3 0.0 2.6 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.6 0.0 1.9 0.0 0.0 0.0 11.1 13.7 0.0 0.0 0.0 0.0 0.0 0.0 33.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 1.8 64.4 3.8 3.3 6.4 2.6 4.2 6.3 3.9 0.5 0.5 1.0 0.0 0.0 9.1 0.5 0.6 0.0 0.0 0.6 30.2 0.5 0.4 5.1 4.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.7 13.6 0.1 0.0 8.3 0.0 7.0 2.6 1.2 0.1 7.5 0.0 0.1 0.0 0.0 128.5 3.3 0.2 0.0 372.4 0.0 0.0 5.3 2.2 6.1 0.0 0.1 0.0 2.8 0.0 0.2 0.0 3.0 10.3 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.3 0.0 0.8 0.7 0.1 0.8 0.0 0.6 0.3 0.4 0.0 0.0 0.0 REPS1 ENSG00000135597 "RALBP1 associated Eps domain containing 1" Q96D71 6 138903493-138988261 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 207.3;Excitatory neurons: 114.3;Inhibitory neurons: 138.1;Oligodendrocyte precursor cells: 99.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029961, HPA029962" Approved Approved "Vesicles,Plasma membrane,Cytosol" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 68: Epididymis - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Vesicles, Plasma membrane, Cytosol" "HPA029961: AB_10603233, HPA029962: AB_2673269" "unprognostic (1.72e-3)" "unprognostic (9.61e-2)" "unprognostic (5.82e-3)" "unprognostic (2.77e-2)" "unprognostic (6.30e-3)" "unprognostic (1.90e-1)" "prognostic unfavorable (9.47e-4)" "unprognostic (3.79e-1)" "unprognostic (2.49e-1)" "unprognostic (9.71e-3)" "unprognostic (4.29e-3)" "unprognostic (4.42e-2)" "unprognostic (2.69e-1)" "unprognostic (1.51e-1)" "unprognostic (1.27e-1)" "unprognostic (3.83e-2)" "unprognostic (2.69e-2)" 13.5 11.9 24.7 14.9 25.4 23.2 23.6 27.7 36.8 19.2 14.8 17.4 15.4 21.9 40.2 28.0 18.4 14.0 23.9 27.4 24.0 17.4 31.3 15.2 19.4 25.2 23.9 21.1 18.8 41.0 31.7 17.2 21.3 15.9 17.3 38.8 26.1 16.2 17.5 30.0 16.4 19.5 21.5 22.1 18.1 35.6 25.9 36.0 17.8 12.6 22.2 19.5 20.1 25.3 29.3 22.6 42.3 53.1 23.4 41.6 46.2 27.8 30.7 31.9 38.2 54.1 24.8 35.2 22.9 38.9 38.0 33.6 48.7 42.0 42.1 37.6 41.9 29.6 12.9 32.9 35.3 94.6 45.9 34.1 33.7 58.6 70.3 30.2 33.5 51.2 40.2 35.1 41.4 49.4 53.9 51.3 40.4 37.4 21.3 62.4 26.0 20.0 26.5 43.6 37.7 37.2 25.7 38.7 38.0 62.0 18.6 64.4 32.9 17.8 29.6 48.5 38.8 34.4 33.7 49.2 21.1 38.3 26.4 5.9 1.3 1.9 2.2 4.0 3.8 3.0 2.9 3.2 1.9 1.6 2.9 3.6 0.7 2.9 4.5 3.5 3.3 1.2 24.7 25.4 27.7 36.8 27.4 24.0 25.2 23.9 21.3 21.5 25.9 25.3 11.8 19.2 7.4 207.3 18.0 13.4 11.7 7.9 22.2 12.6 13.7 9.5 28.4 10.0 12.2 5.5 16.7 25.6 18.9 11.9 7.9 7.8 13.7 17.5 9.7 10.3 6.0 5.0 114.3 7.1 28.3 11.5 16.3 23.3 15.9 14.4 15.7 43.8 13.3 13.5 138.1 12.8 6.1 24.0 10.3 7.7 7.2 17.2 5.4 47.8 10.5 36.8 15.5 99.5 71.2 8.9 14.7 8.6 23.9 11.2 13.5 8.6 16.5 14.4 19.7 16.8 10.9 41.7 33.8 26.4 14.9 28.6 18.7 7.6 15.2 18.1 REST "DFNA27, NRSF, XBR" ENSG00000084093 "RE1 silencing transcription factor" Q13127 4 56907876-56966808 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" Repressor "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006079, CAB068222" Supported Supported Nucleoplasm,Cytosol NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 34: Non-specific - Transcription" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Cytosol" "CAB068222: AB_2665651, HPA006079: AB_1079801" "unprognostic (7.49e-3)" "unprognostic (3.36e-2)" "unprognostic (2.50e-2)" "unprognostic (2.03e-2)" "unprognostic (1.86e-1)" "unprognostic (1.39e-1)" "unprognostic (7.47e-3)" "unprognostic (2.30e-1)" "unprognostic (4.65e-2)" "unprognostic (1.70e-2)" "unprognostic (4.32e-3)" "unprognostic (1.73e-1)" "prognostic favorable (9.50e-5)" "unprognostic (1.49e-1)" "unprognostic (1.59e-1)" "unprognostic (1.24e-1)" "unprognostic (4.79e-2)" 6.9 5.5 5.7 9.4 6.5 24.8 9.8 6.3 7.5 8.8 9.4 6.9 6.4 9.3 8.9 8.2 7.8 7.9 7.6 5.0 5.2 10.9 11.5 8.0 13.4 8.0 6.6 11.2 7.7 13.8 0.5 9.9 7.8 10.0 7.0 7.5 7.8 8.1 5.2 8.9 6.3 8.0 6.6 10.7 8.2 12.3 6.8 18.1 10.9 6.5 13.6 8.7 2.1 7.4 10.8 13.0 17.4 18.2 13.2 16.0 22.7 15.6 13.8 16.0 14.7 11.5 16.5 24.5 23.5 16.8 10.7 9.8 13.2 16.3 24.4 12.6 8.1 22.0 9.4 12.5 16.2 29.0 13.5 16.5 14.6 15.1 16.0 20.5 20.1 19.0 14.3 26.3 19.0 17.3 31.5 21.3 15.2 12.3 8.9 30.0 14.5 8.1 19.0 18.3 0.3 8.1 17.8 18.8 14.6 24.8 19.3 20.3 28.7 20.4 18.1 12.4 14.2 10.8 7.8 15.1 13.2 16.7 10.8 7.4 2.5 7.2 6.2 3.9 6.2 11.6 6.9 5.9 5.2 21.1 10.8 4.4 2.8 6.1 7.9 6.0 9.4 2.5 5.7 6.5 6.3 7.5 5.0 5.2 8.0 6.6 7.8 6.6 6.8 7.4 38.1 70.5 60.2 18.6 51.1 57.1 51.9 33.3 99.6 1.6 42.6 35.2 50.2 42.9 43.3 29.5 81.3 58.0 65.2 21.4 23.5 58.4 9.7 67.3 64.3 50.5 3.6 54.7 0.1 38.2 57.1 40.8 23.9 63.4 51.4 56.3 47.2 31.0 32.2 0.0 0.2 23.5 44.7 36.2 37.9 11.9 39.4 44.0 21.4 12.2 78.0 45.1 71.1 11.1 21.1 45.8 29.0 36.9 44.3 44.3 22.1 24.4 43.3 36.1 32.9 56.5 56.0 58.3 53.8 55.0 45.7 66.4 66.6 62.3 26.1 48.7 RET "CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51" ENSG00000165731 "Ret proto-oncogene" P07949 10 43077064-43130351 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Hirschsprung disease, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "adrenal gland: 20.8;brain: 27.3;parathyroid gland: 31.8" "Group enriched" "Detected in some" 4 "Horizontal cells: 79.1;Ionocytes: 26.4;Skeletal myocytes: 23.1" "Cancer enhanced" "Detected in many" "breast cancer: 11.0" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "MCF7: 74.6;NB-4: 42.2;SH-SY5Y: 329.3;THP-1: 95.9" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "midbrain: 53.3;spinal cord: 19.4" "CAB002581, HPA008356, HPA008495" Approved Supported Approved "Golgi apparatus,Plasma membrane,Cytosol" No NA 2100000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 50: Fibroblasts - ECM organization" "Golgi apparatus, Cytosol" "Plasma membrane" "CAB002581: AB_563673, HPA008356: AB_1847232, HPA008495: " "unprognostic (7.94e-2)" "unprognostic (3.68e-2)" "unprognostic (4.49e-1)" "prognostic unfavorable (5.02e-4)" "unprognostic (1.15e-1)" "unprognostic (9.13e-4)" "unprognostic (1.27e-2)" "unprognostic (3.62e-2)" "unprognostic (2.86e-1)" "unprognostic (2.01e-1)" "unprognostic (1.54e-3)" "unprognostic (4.43e-1)" "unprognostic (9.35e-5)" "unprognostic (1.64e-3)" "unprognostic (8.28e-2)" "unprognostic (3.67e-3)" "unprognostic (2.02e-2)" 1.8 20.8 1.0 1.3 0.9 0.4 1.1 5.1 5.6 1.0 0.2 3.4 1.4 0.6 0.3 0.4 0.5 0.6 2.2 0.3 5.5 0.9 3.0 0.4 0.6 14.4 27.3 0.4 1.3 31.8 5.3 0.5 12.0 1.8 1.4 4.7 5.1 2.0 5.9 0.9 1.4 1.0 4.8 0.2 2.2 2.7 7.6 1.6 0.8 3.1 0.2 0.6 1.4 5.8 0.1 0.4 0.1 1.7 0.0 0.0 0.1 0.7 0.2 0.4 0.1 0.0 0.0 0.0 0.1 0.0 0.6 0.0 5.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 7.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 74.6 0.0 42.2 7.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 4.7 329.3 0.1 0.0 0.1 0.5 4.1 95.9 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.9 0.7 0.1 0.0 1.0 0.9 5.1 5.6 0.3 5.5 14.4 27.3 12.0 4.8 7.6 5.8 0.4 0.0 0.5 1.6 0.0 0.3 0.8 0.0 0.0 1.7 6.0 0.5 2.1 0.0 0.0 0.0 0.0 0.0 2.1 0.2 0.0 0.0 1.5 0.0 0.3 1.1 0.0 0.0 4.2 0.2 2.3 6.8 0.0 0.0 1.3 0.5 0.0 1.2 0.1 79.1 8.6 1.9 26.4 0.0 0.6 1.5 0.3 0.5 0.0 1.0 0.0 0.8 0.0 1.0 0.6 0.0 0.0 0.0 0.0 0.9 0.0 0.1 0.8 1.7 0.0 23.1 1.2 1.1 4.7 0.0 0.6 0.0 0.2 0.3 0.2 0.1 RETREG1 "FAM134B, FLJ20152, JK1" ENSG00000154153 "Reticulophagy regulator 1" Q9H6L5 5 16473038-16617038 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" Autophagy "Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 91.4;skeletal muscle: 141.8" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 73.7;Cytotrophoblasts: 53.7;Exocrine glandular cells: 59.3;Glandular and luminal cells: 197.7;Pancreatic endocrine cells: 51.5;Proximal tubular cells: 152.8" "Cancer enhanced" "Detected in all" "renal cancer: 28.3" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "basophil: 2.3" "Group enriched" "Detected in many" 6 "granulocytes: 2.3;T-cells: 1.7" "Cell line enhanced" "Detected in many" "ASC diff: 26.0;GAMG: 20.3;HSkMC: 28.8;MOLT-4: 20.4;RPTEC TERT1: 26.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA012077 Supported "Endoplasmic reticulum" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 44: Endometrium - Transcription" "Endoplasmic reticulum" "HPA012077: AB_2668621" "unprognostic (1.63e-2)" "unprognostic (1.98e-1)" "unprognostic (1.80e-2)" "unprognostic (1.84e-2)" "unprognostic (4.96e-2)" "unprognostic (9.17e-3)" "unprognostic (2.66e-2)" "unprognostic (1.90e-1)" "unprognostic (4.35e-2)" "unprognostic (4.41e-2)" "unprognostic (1.37e-2)" "unprognostic (1.48e-1)" "prognostic favorable (5.25e-10)" "unprognostic (3.75e-1)" "unprognostic (9.96e-2)" "unprognostic (5.62e-2)" "unprognostic (2.58e-1)" 15.6 3.5 20.6 6.6 26.4 2.0 13.6 23.9 33.2 13.2 21.6 24.6 12.6 4.0 5.2 3.6 7.5 13.4 91.4 19.4 22.1 61.0 44.2 9.3 6.4 27.2 25.2 2.1 37.7 30.1 9.9 13.2 27.8 11.1 32.4 7.5 5.2 5.0 141.8 10.0 25.6 2.6 23.6 2.3 10.9 12.3 25.0 20.6 6.7 81.9 4.3 2.3 5.2 37.6 1.3 0.5 0.1 3.5 26.0 3.2 15.1 0.1 3.5 3.1 4.1 2.3 0.1 0.3 2.4 0.0 20.3 3.9 7.8 0.8 1.0 4.1 3.4 0.0 10.6 0.0 0.1 5.3 0.0 28.8 11.7 0.6 3.1 7.5 0.0 15.4 0.0 0.1 1.2 1.0 20.4 0.1 0.8 3.4 0.6 3.2 0.0 1.2 26.2 0.9 17.4 2.0 1.0 1.1 13.1 1.9 5.9 2.4 0.0 2.4 0.2 6.4 3.1 0.7 0.0 0.0 14.9 18.0 6.5 2.3 0.1 0.0 0.2 0.0 0.6 0.0 0.6 0.3 0.0 0.3 1.7 1.0 0.9 0.0 0.0 0.0 0.8 0.2 20.6 26.4 23.9 33.2 19.4 22.1 27.2 25.2 27.8 23.6 25.0 37.6 4.2 73.7 8.6 0.0 3.4 0.0 0.0 0.0 0.0 0.0 33.3 19.0 0.0 0.0 9.9 44.1 0.0 53.7 2.2 0.0 17.6 31.1 0.0 33.5 45.2 1.2 0.0 0.0 0.0 59.3 2.0 7.8 0.0 197.7 1.3 3.3 0.0 0.0 3.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.7 0.0 0.0 1.0 0.0 0.0 0.0 0.0 51.5 0.0 0.0 0.8 0.0 0.0 152.8 19.0 0.0 0.0 0.0 5.1 0.0 0.0 0.0 0.0 10.9 8.1 0.3 0.0 0.0 RFC1 "A1, MHCBFB, PO-GA, RFC140" ENSG00000035928 "Replication factor C subunit 1" P35251 4 39287456-39366375 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "DNA replication, Transcription, Transcription regulation" "Activator, DNA-binding" Neuropathy "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009520, HPA046116, HPA069306" Supported Enhanced Nucleoplasm NA NA "Cluster 6: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" Nucleoplasm "CAB009520: AB_2178317, HPA046116: AB_2679544, HPA069306: AB_2686115" "unprognostic (8.23e-2)" "unprognostic (2.30e-1)" "prognostic favorable (4.43e-5)" "unprognostic (4.15e-2)" "unprognostic (4.08e-2)" "unprognostic (3.38e-2)" "unprognostic (7.48e-2)" "unprognostic (3.30e-1)" "unprognostic (4.70e-2)" "unprognostic (2.47e-1)" "unprognostic (4.17e-2)" "unprognostic (4.14e-2)" "unprognostic (1.62e-3)" "unprognostic (4.48e-2)" "unprognostic (1.31e-1)" "unprognostic (5.41e-2)" "unprognostic (1.47e-2)" 15.6 19.0 13.7 16.7 19.2 33.1 22.2 15.4 15.6 16.9 12.0 15.3 13.3 19.2 17.4 13.8 14.6 12.2 16.5 13.5 14.9 20.8 25.5 18.2 30.2 16.5 15.6 26.1 29.0 31.4 14.7 14.6 18.0 17.8 14.8 24.3 16.6 16.1 11.6 14.9 13.8 17.1 15.4 17.0 14.9 11.8 14.8 28.0 23.1 15.9 30.2 13.5 14.1 25.5 43.5 19.4 53.7 44.1 25.4 32.0 27.5 49.1 44.6 49.2 58.2 37.8 43.1 106.5 32.4 33.2 52.8 20.7 49.8 42.6 78.5 19.5 33.9 48.0 35.6 34.7 30.6 67.5 30.7 24.6 33.8 49.9 55.3 39.1 38.8 52.1 48.0 22.1 37.9 17.5 99.7 43.4 33.0 26.8 24.2 78.1 97.8 33.7 21.4 30.1 37.6 36.4 29.1 11.3 37.6 33.4 29.8 37.5 30.0 40.3 49.6 37.8 63.1 31.0 45.8 101.3 33.1 69.3 41.2 8.2 8.6 3.8 13.7 6.9 10.1 14.6 11.7 11.9 6.9 16.1 13.8 12.2 3.9 12.6 8.9 14.3 11.5 5.5 13.7 19.2 15.4 15.6 13.5 14.9 16.5 15.6 18.0 15.4 14.8 25.5 65.5 64.1 120.6 33.0 62.9 20.6 37.9 26.5 47.3 67.8 60.5 62.4 86.1 45.8 37.0 57.0 60.5 43.1 83.8 30.6 72.4 54.8 73.0 45.9 79.1 56.1 30.0 57.9 22.0 66.0 48.5 54.9 28.1 60.0 25.9 82.2 57.8 82.0 30.7 85.8 32.1 58.2 12.2 44.3 16.6 32.3 82.0 35.1 16.0 22.5 58.1 82.7 107.1 38.7 95.7 51.1 34.2 91.7 75.0 50.0 36.1 124.2 32.6 83.3 59.2 61.6 54.6 49.0 66.5 38.2 21.3 32.2 63.7 70.8 49.1 44.5 RGR RP44 ENSG00000148604 "Retinal G protein coupled receptor" P47804 10 84230666-84259960 "Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Sensory transduction, Vision" "G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 9 "retina: 139.0" "Cell type enriched" "Detected in some" 29 "Muller glia cells: 1475.8" "Cancer enriched" "Detected in single" 4 "glioma: 0.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 6 "midbrain: 23.4;olfactory bulb: 49.7;thalamus: 27.3" HPA059149 Approved "Vesicles,Plasma membrane,Cytosol" NA NA "Cluster 77: Retina - Visual perception" "Cluster 5: Muller glia cells - Visual perception" Vesicles "Plasma membrane, Cytosol" "HPA059149: " "unprognostic (9.28e-2)" "unprognostic (1.05e-1)" "unprognostic (1.37e-1)" "unprognostic (9.53e-2)" "unprognostic (4.57e-2)" "unprognostic (1.57e-1)" "unprognostic (1.59e-1)" "unprognostic (1.97e-1)" 0.2 0.0 11.9 0.0 11.9 0.0 0.1 4.4 14.6 0.0 14.4 0.1 0.0 0.0 0.1 0.1 0.1 0.0 0.5 7.4 8.5 0.0 0.0 0.2 0.0 5.2 8.2 0.0 0.0 0.0 0.4 0.0 5.4 0.0 0.0 139.0 0.1 0.0 0.0 0.1 0.1 0.0 3.1 0.0 0.2 0.9 10.1 0.0 0.0 0.0 0.0 0.0 0.0 6.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.9 11.9 4.4 14.6 7.4 8.5 5.2 8.2 5.4 3.1 10.1 6.2 0.0 0.0 0.0 6.8 0.0 0.0 0.1 0.0 0.0 20.6 0.1 0.1 0.4 0.0 0.0 0.0 31.3 0.0 0.0 0.1 0.0 0.0 8.6 0.0 0.0 1.7 0.0 0.0 0.1 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 0.1 0.0 0.0 0.0 0.0 10.6 0.3 0.0 0.0 0.0 0.0 1475.8 0.0 2.5 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 49.6 0.0 2.8 0.0 0.9 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 RGS9 "MGC111763, MGC26458, PERRS, RGS9L" ENSG00000108370 "Regulator of G protein signaling 9" O75916 17 65100812-65227703 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Sensory transduction, Vision" "Signal transduction inhibitor" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 23.5" "Group enriched" "Detected in many" 6 "Cone photoreceptor cells: 325.2;Rod photoreceptor cells: 480.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 6 "gdT-cell: 9.7;MAIT T-cell: 2.5;memory CD8 T-cell: 6.8;naive CD8 T-cell: 3.2;NK-cell: 4.0" "Group enriched" "Detected in many" 42 "NK-cells: 4.0;T-cells: 9.7" "Cell line enhanced" "Detected in some" "HDLM-2: 25.9;HEL: 11.7;hTERT-RPE1: 4.7;SuSa: 4.1" "Region enriched" "Detected in all" 9 "basal ganglia: 248.1" "Region enriched" "Detected in all" 10 "basal ganglia: 110.0" "HPA013550, HPA014137" Enhanced Supported Approved Nucleoplasm,Vesicles NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 44: HDLM-2 - Immune response" "Cluster 46: Photoreceptor cells - Phototransduction" "Nucleoplasm, Vesicles" "HPA013550: , HPA014137: AB_2668943" "unprognostic (4.43e-3)" "unprognostic (7.49e-3)" "unprognostic (5.12e-2)" "unprognostic (3.09e-5)" "unprognostic (1.07e-1)" "unprognostic (1.14e-1)" "unprognostic (3.17e-1)" "unprognostic (1.93e-1)" "unprognostic (1.20e-1)" "unprognostic (4.88e-2)" "prognostic favorable (1.35e-4)" "unprognostic (1.07e-1)" "unprognostic (5.07e-2)" "unprognostic (4.94e-2)" "unprognostic (3.69e-1)" "unprognostic (1.51e-1)" "unprognostic (1.49e-1)" 0.8 1.5 6.2 1.2 23.5 0.2 0.8 4.3 9.4 1.6 3.8 8.5 1.1 1.7 2.5 1.5 10.3 1.0 0.8 5.1 9.3 2.4 2.3 5.1 2.1 5.3 5.9 2.6 1.4 5.5 12.1 1.2 6.9 4.6 1.3 1.3 1.3 3.3 0.1 1.4 3.8 1.4 5.2 1.7 3.8 0.4 7.4 0.6 0.6 0.3 3.0 2.9 2.8 4.6 0.4 0.0 1.3 0.1 0.1 0.2 0.0 0.1 2.6 0.0 0.3 0.2 0.0 1.2 1.8 0.0 0.0 0.1 0.0 0.1 0.1 25.9 0.6 11.7 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 4.7 0.0 0.1 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.0 0.0 0.3 0.0 0.0 0.2 4.1 0.0 0.0 0.4 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 9.7 0.0 2.5 0.0 0.8 6.8 0.0 0.0 0.0 3.2 0.1 4.0 0.0 0.1 0.0 1.7 6.2 23.5 4.3 9.4 5.1 9.3 5.3 5.9 6.9 5.2 7.4 4.6 1.3 3.2 1.5 33.3 0.4 0.4 1.4 0.9 0.6 25.0 7.8 14.5 0.4 0.0 1.3 1.8 325.2 0.0 27.5 0.1 3.9 8.9 0.6 2.5 1.8 2.6 59.7 0.0 2.3 3.1 0.1 5.8 1.1 4.2 0.0 3.3 1.1 0.0 0.1 52.2 2.3 2.3 0.0 0.0 3.0 2.4 0.9 2.9 1.8 1.9 19.4 39.2 18.6 2.5 1.2 2.7 0.1 4.9 6.3 0.1 0.1 14.2 0.8 480.2 0.0 0.5 1.9 0.1 0.4 0.0 0.1 0.1 10.3 12.8 0.6 0.3 RGS9BP "FLJ45744, PERRS, R9AP" ENSG00000186326 "Regulator of G protein signaling 9 binding protein" Q6ZS82 19 32675848-32678300 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Sensory transduction, Vision" "Signal transduction inhibitor" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "choroid plexus: 28.9;retina: 17.4;skeletal muscle: 9.0" "Group enriched" "Detected in some" 5 "Bipolar cells: 29.0;Cone photoreceptor cells: 56.3;Rod photoreceptor cells: 75.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HEL: 6.3;HMC-1: 1.6" "Not detected" "Not detected" "Not detected" "Not detected" HPA049791 Enhanced Approved "Plasma membrane" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 77: Retina - Visual perception" "Cluster 36: HEL - Hemostasis" "Cluster 46: Photoreceptor cells - Phototransduction" "Plasma membrane" "HPA049791: AB_2680884" "unprognostic (2.82e-2)" "unprognostic (6.99e-3)" "unprognostic (2.44e-3)" "unprognostic (1.20e-7)" "unprognostic (1.49e-1)" "unprognostic (1.21e-2)" "unprognostic (1.17e-2)" "unprognostic (1.32e-1)" "unprognostic (2.80e-1)" "unprognostic (6.71e-2)" "unprognostic (6.74e-2)" "unprognostic (3.89e-2)" "unprognostic (1.63e-3)" "unprognostic (2.29e-1)" "unprognostic (8.22e-2)" "unprognostic (5.23e-2)" "unprognostic (5.34e-2)" 0.0 0.1 0.8 0.0 0.7 0.0 0.0 0.8 0.8 0.0 28.9 0.1 0.0 0.0 0.1 0.4 0.0 0.0 1.3 3.3 0.9 0.3 0.0 0.3 0.0 1.1 1.4 0.0 0.0 0.2 0.2 0.0 0.9 0.2 0.0 17.4 0.1 0.1 9.0 0.1 0.0 0.0 0.5 0.0 0.1 0.4 1.5 0.1 0.0 3.2 0.0 0.4 0.0 0.7 0.1 0.1 0.0 0.5 0.3 0.1 0.3 0.0 0.3 0.2 0.1 0.0 0.1 0.1 0.3 0.0 0.3 0.0 1.0 0.0 0.0 0.2 0.1 6.3 0.1 0.0 0.1 0.1 1.6 0.0 0.3 0.0 0.2 0.1 0.0 0.0 0.4 0.8 0.1 0.2 0.0 1.0 0.0 0.0 1.1 0.1 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.6 0.0 0.0 0.6 0.3 0.0 0.2 0.3 0.1 0.1 0.3 0.4 0.0 0.1 0.3 0.4 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.7 0.8 0.8 3.3 0.9 1.1 1.4 0.9 0.5 1.5 0.7 0.2 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 29.0 0.4 0.4 4.6 0.0 0.0 1.8 56.3 0.3 0.6 0.5 0.0 0.0 5.1 0.2 0.1 0.7 0.0 0.8 0.0 0.0 0.2 0.2 0.0 0.4 0.0 1.8 0.7 0.0 0.2 1.7 0.0 0.0 0.0 0.3 0.0 1.5 0.0 0.1 0.0 0.0 0.0 9.4 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.2 0.4 0.9 0.0 75.4 0.0 0.4 0.2 0.5 0.4 0.0 0.0 0.0 0.1 1.1 0.4 0.0 RHO "CSNBAD1, OPN2, RP4" ENSG00000163914 Rhodopsin P08100 3 129528639-129535344 "Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Sensory transduction, Vision" "G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer" "Congenital stationary night blindness, Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 5994 "retina: 4062.1" "Cell type enriched" "Detected in some" 7 "Rod photoreceptor cells: 4509.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in some" 4 "hippocampal formation: 9.7" "Region enhanced" "Detected in single" "hippocampal formation: 1.1" "HPA013440, CAB022486, CAB034887, CAB034888" Enhanced NA NA "Cluster 79: Retina - Phototransduction" "Cluster 46: Photoreceptor cells - Phototransduction" "CAB022486: , CAB034887: AB_785511, CAB034888: AB_785512, HPA013440: AB_2668844" "unprognostic (4.32e-2)" "unprognostic (1.21e-1)" "unprognostic (1.68e-1)" "unprognostic (1.83e-1)" "unprognostic (2.87e-1)" "unprognostic (1.94e-1)" "unprognostic (9.19e-11)" "unprognostic (4.24e-2)" "unprognostic (1.84e-1)" "unprognostic (2.91e-1)" 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4062.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 369.9 0.0 0.0 0.6 0.0 0.0 0.0 454.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 26.5 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 218.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 590.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4509.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 RHOBTB2 "DBC2, KIAA0717" ENSG00000008853 "Rho related BTB domain containing 2" Q9BYZ6 8 22987417-23020199 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lung: 50.5" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 64.1;Alveolar cells type 2: 77.7;Excitatory neurons: 33.3;Proximal enterocytes: 57.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Daudi: 85.7;hTCEpi: 73.6;RT4: 126.9" "Low region specificity" "Detected in all" HPA060938 Approved Approved "Plasma membrane" NA NA "Cluster 37: B-cells - Transcription" "Cluster 10: Brain - Neuronal signaling" "Cluster 15: RT4 - Unknown function" "Cluster 11: Alveolar cells - Smell perception" "Plasma membrane" "HPA060938: AB_2684391" "unprognostic (2.67e-3)" "unprognostic (1.64e-1)" "unprognostic (1.64e-1)" "unprognostic (7.94e-2)" "unprognostic (7.83e-3)" "unprognostic (2.13e-2)" "unprognostic (8.13e-2)" "unprognostic (8.17e-2)" "unprognostic (3.47e-3)" "unprognostic (1.93e-2)" "unprognostic (1.60e-2)" "unprognostic (1.46e-2)" "prognostic favorable (2.98e-4)" "unprognostic (2.01e-1)" "unprognostic (1.09e-1)" "unprognostic (8.89e-3)" "unprognostic (2.43e-1)" 6.5 8.8 17.9 7.5 31.7 2.3 8.4 3.6 27.6 6.8 7.1 6.2 8.5 7.7 5.3 4.8 9.8 6.5 21.8 21.4 7.3 11.2 2.4 50.5 14.9 4.2 10.3 25.8 8.0 9.6 14.2 11.2 4.1 7.7 2.5 5.6 6.4 23.0 16.5 5.5 21.2 6.5 0.8 12.6 8.3 8.1 22.8 8.9 18.5 13.6 16.7 10.4 4.5 15.1 6.8 13.2 10.4 16.7 12.4 8.7 14.0 9.2 12.0 14.2 10.7 34.2 6.6 85.7 13.8 13.3 18.5 13.2 5.0 51.5 6.8 7.4 3.0 9.3 17.8 9.7 6.0 5.5 18.5 11.3 73.6 14.8 7.4 9.8 10.4 6.1 2.3 8.2 9.5 19.7 3.5 8.8 11.0 19.7 9.2 4.7 16.8 5.9 10.1 126.9 6.8 12.5 7.1 21.2 14.5 7.7 4.0 14.0 12.8 17.7 12.8 32.0 10.6 20.7 21.5 30.2 17.2 7.9 14.0 2.9 0.6 0.8 1.7 1.0 1.1 5.1 0.4 0.8 0.6 4.3 0.6 0.6 0.1 2.9 1.1 1.8 0.9 0.8 17.9 31.7 3.6 27.6 21.4 7.3 4.2 10.3 4.1 0.8 22.8 15.1 4.1 64.1 77.7 13.1 7.6 2.9 2.5 5.2 2.8 31.1 2.9 3.2 10.2 5.7 9.1 7.3 4.2 14.7 4.5 0.2 1.9 2.1 0.8 1.9 4.8 6.2 6.0 1.3 33.3 3.7 8.5 5.5 6.1 3.2 4.5 2.4 7.9 1.9 14.3 16.8 13.1 5.8 0.0 2.5 2.6 0.8 6.2 3.5 1.8 5.6 1.5 7.3 8.2 7.1 1.8 4.1 2.6 6.4 4.2 1.2 57.2 6.2 3.1 6.1 0.0 7.2 4.2 0.9 1.9 0.5 0.6 5.6 2.5 2.9 2.8 0.9 RIMS1 "CORD7, KIAA0340, RAB3IP2, RIM, RIM1" ENSG00000079841 "Regulating synaptic membrane exocytosis 1" Q86UR5 6 71886703-72403143 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Differentiation, Exocytosis, Neurotransmitter transport, Sensory transduction, Transport, Vision" "Cone-rod dystrophy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 49 "brain: 365.0" "Group enriched" "Detected in many" 4 "Excitatory neurons: 653.2;Inhibitory neurons: 572.7;Oligodendrocyte precursor cells: 323.2" "Cancer enhanced" "Detected in single" "prostate cancer: 0.7" "Region enriched" "Detected in many" 16 "cerebellum: 365.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "Daudi: 5.2;EFO-21: 8.8;LHCN-M2: 10.0;RPTEC TERT1: 15.0;SH-SY5Y: 10.7;TIME: 5.4;U-138 MG: 5.1" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebellum: 352.9" HPA076565 Enhanced NA NA "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA076565: " "unprognostic (1.34e-3)" "unprognostic (3.47e-1)" "unprognostic (1.48e-1)" "unprognostic (1.63e-3)" "unprognostic (6.62e-2)" "unprognostic (1.16e-1)" "unprognostic (1.73e-2)" "unprognostic (8.57e-2)" "unprognostic (2.85e-1)" "unprognostic (7.76e-4)" "unprognostic (2.42e-2)" "unprognostic (2.29e-1)" "unprognostic (7.91e-2)" "unprognostic (2.76e-1)" "unprognostic (5.74e-2)" "unprognostic (1.07e-2)" 0.2 1.2 5.5 0.8 14.1 0.0 0.5 365.0 22.5 0.3 0.0 0.3 0.7 0.2 0.0 2.1 0.0 3.9 0.1 16.3 8.4 0.0 0.0 0.2 0.0 0.3 9.0 0.0 0.4 1.6 2.4 0.0 20.8 3.0 0.1 7.4 1.1 0.3 0.2 0.2 0.4 0.7 0.0 0.0 1.4 4.1 5.4 0.0 0.0 0.9 0.0 0.1 0.0 13.2 0.0 0.0 1.0 0.0 0.0 0.5 0.0 0.2 1.4 0.0 0.2 0.0 0.0 5.2 8.8 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 4.0 0.4 1.6 0.0 0.0 0.0 0.0 10.0 0.0 0.0 0.0 0.9 0.0 0.1 0.0 0.0 0.5 15.0 0.0 0.4 10.7 0.0 0.0 0.0 0.3 0.7 0.0 5.4 5.1 0.1 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.5 14.1 365.0 22.5 16.3 8.4 0.3 9.0 20.8 0.0 5.4 13.2 0.2 0.0 0.5 120.2 0.0 0.0 0.2 2.1 0.0 69.1 3.0 3.2 1.4 0.0 6.8 0.0 0.0 0.0 0.0 0.0 0.0 0.2 15.2 0.0 0.9 2.5 0.0 0.0 653.2 0.8 0.0 1.8 0.0 0.0 1.3 0.3 3.6 0.0 0.0 62.2 572.7 0.0 2.0 0.0 0.0 10.2 0.3 0.3 3.6 16.9 0.0 109.7 0.0 323.2 76.5 0.5 0.0 1.5 0.0 1.0 0.0 0.4 3.6 9.9 0.0 1.3 2.7 21.3 13.6 0.0 0.1 0.0 0.1 0.3 0.0 0.5 RIMS2 "KIAA0751, OBOE, RAB3IP3, RIM2" ENSG00000176406 "Regulating synaptic membrane exocytosis 2" Q9UQ26 8 103500696-104256094 "Human disease related genes, Predicted intracellular proteins" Differentiation "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "adrenal gland: 50.6;brain: 48.2;retina: 102.3" "Cell type enhanced" "Detected in many" "Bipolar cells: 383.6;Cone photoreceptor cells: 706.8;Excitatory neurons: 1589.3;Inhibitory neurons: 1234.9;Oligodendrocyte precursor cells: 577.0;Rod photoreceptor cells: 1088.7" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "Daudi: 9.2;RT4: 7.3;SCLC-21H: 16.5;SuSa: 8.8;U-2 OS: 6.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046538, HPA066498, CAB079049" Enhanced Supported Approved "Plasma membrane,Cytosol" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 58: Brain - Synaptic function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 46: Photoreceptor cells - Phototransduction" "Plasma membrane, Cytosol" "CAB079049: , HPA046538: , HPA066498: AB_2685678" "unprognostic (2.98e-2)" "unprognostic (7.14e-2)" "unprognostic (4.47e-2)" "unprognostic (5.51e-2)" "unprognostic (2.82e-1)" "unprognostic (7.09e-3)" "unprognostic (2.02e-2)" "unprognostic (1.16e-2)" "unprognostic (7.61e-2)" "unprognostic (8.01e-3)" "unprognostic (1.40e-2)" "unprognostic (6.34e-2)" "unprognostic (1.67e-5)" "unprognostic (8.12e-4)" "unprognostic (1.04e-1)" "unprognostic (1.61e-1)" "unprognostic (9.08e-2)" 0.2 50.6 22.4 0.2 27.1 0.4 0.7 35.5 48.2 7.5 0.0 0.1 0.4 0.6 0.9 0.3 5.9 0.9 0.1 18.4 16.4 0.3 0.1 0.1 0.3 5.5 9.7 2.0 0.7 0.0 15.0 0.4 6.4 1.7 0.1 102.3 0.8 1.0 0.2 0.3 0.5 1.3 3.5 0.1 0.6 2.8 16.7 0.8 1.3 0.1 0.2 1.7 2.4 29.4 4.6 0.0 4.8 0.0 0.0 0.1 0.0 0.4 0.3 1.0 1.3 0.1 0.3 9.2 0.1 0.1 1.4 0.3 1.9 0.8 2.2 0.0 0.3 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.7 0.0 1.0 1.5 0.0 1.2 0.0 0.5 0.0 0.4 0.9 0.0 4.0 0.0 0.5 0.0 0.0 0.0 0.0 7.3 16.5 3.3 0.0 0.1 0.7 8.8 0.4 0.2 0.0 0.0 6.5 0.1 0.1 1.2 0.0 0.1 0.4 0.3 0.3 0.8 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.5 0.1 0.0 0.1 0.0 0.0 22.4 27.1 35.5 48.2 18.4 16.4 5.5 9.7 6.4 3.5 16.7 29.4 0.4 28.9 22.5 38.5 0.2 0.3 1.8 2.8 1.8 383.6 0.7 0.6 0.9 1.5 16.9 0.0 706.8 0.5 0.1 0.2 1.9 0.1 34.2 2.1 0.4 4.9 8.4 0.0 1589.3 0.0 0.3 3.7 0.0 3.7 16.4 18.0 0.7 0.3 0.3 67.3 1234.9 0.9 0.0 0.6 0.8 20.1 72.1 2.5 1.8 63.7 0.6 86.6 1.0 577.0 27.0 0.3 1.2 29.3 0.3 4.1 2.0 0.2 10.6 1088.7 0.0 0.8 1.0 34.8 15.7 0.8 0.4 0.1 2.1 0.1 1.5 1.1 RIPOR2 "C6orf32, DIFF48, FAM65B, KIAA0386, MYONAP" ENSG00000111913 "RHO family interacting cell polarization regulator 2" Q9Y4F9 6 24804282-25042170 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cell adhesion, Chemotaxis, Differentiation, Hearing, Myogenesis" "Developmental protein, Signal transduction inhibitor" "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 82.6" "Cell type enhanced" "Detected in many" "B-cells: 57.4;dendritic cells: 98.4;Respiratory ciliated cells: 83.1;Syncytiotrophoblasts: 82.8;T-cells: 38.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in all" "neutrophil: 951.9" "Lineage enriched" "Detected in all" 5 "granulocytes: 951.9" "Cell line enhanced" "Detected in many" "AF22: 30.9;Daudi: 73.5;fHDF/TERT166: 73.2;U-266/70: 25.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 16: Immune cells - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 7: Non-specific - Mitochondria" "unprognostic (4.05e-3)" "unprognostic (1.34e-3)" "unprognostic (3.55e-2)" "unprognostic (1.91e-2)" "unprognostic (1.47e-2)" "unprognostic (1.75e-2)" "unprognostic (5.89e-4)" "unprognostic (2.62e-2)" "unprognostic (1.54e-1)" "unprognostic (4.40e-3)" "unprognostic (1.64e-1)" "unprognostic (1.74e-2)" "unprognostic (8.55e-2)" "unprognostic (3.33e-2)" "unprognostic (2.30e-2)" "unprognostic (9.79e-2)" "unprognostic (1.14e-1)" 13.1 3.7 15.9 49.1 22.4 27.6 6.1 0.4 16.7 13.5 2.5 3.7 2.7 46.3 2.6 3.2 14.8 8.6 3.1 14.0 9.1 3.0 4.3 20.7 82.6 4.5 9.5 2.7 2.5 0.9 13.0 6.0 3.2 6.1 3.8 3.7 8.2 4.5 19.5 5.2 17.5 17.7 4.6 55.9 6.7 6.4 9.2 41.0 2.9 7.6 71.0 10.2 7.4 4.9 1.1 0.1 30.9 0.6 0.3 0.2 11.3 8.8 15.5 3.7 5.4 0.4 0.5 73.5 2.0 73.2 0.5 0.9 0.0 0.0 0.7 7.3 0.4 17.8 1.2 0.3 0.6 0.4 1.3 3.2 0.3 0.0 0.4 0.2 0.0 3.2 1.0 12.2 0.2 0.2 17.0 0.8 2.3 1.2 2.1 18.5 3.0 0.7 0.1 0.4 1.5 0.3 0.6 0.3 5.7 10.3 0.3 0.5 0.3 0.7 3.3 0.8 0.9 25.4 0.6 2.4 0.8 1.0 5.1 414.0 100.8 334.5 128.6 127.3 134.8 188.3 131.8 136.6 68.7 176.3 171.6 136.8 951.9 125.7 173.8 57.7 124.9 168.1 15.9 22.4 0.4 16.7 14.0 9.1 4.5 9.5 3.2 4.6 9.2 4.9 7.3 3.2 14.6 0.0 57.4 0.0 0.0 0.0 0.0 0.0 3.3 1.7 0.0 0.0 18.6 5.5 0.0 4.1 98.4 0.0 1.9 0.1 0.0 16.4 10.5 2.8 0.0 0.0 0.0 0.2 1.9 2.7 0.0 10.7 12.6 0.6 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 25.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 15.6 0.0 0.0 3.1 83.1 0.0 0.0 0.0 5.2 0.0 0.0 0.0 0.0 82.8 38.0 1.7 0.0 0.0 RLBP1 CRALBP ENSG00000140522 "Retinaldehyde binding protein 1" P12271 15 89209869-89221614 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Sensory transduction, Transport, Vision" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 13 "retina: 265.6" "Cell type enriched" "Detected in some" 34 "Muller glia cells: 3148.2" "Group enriched" "Detected in some" 30 "glioma: 3.7;melanoma: 7.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 53 "SK-MEL-30: 22.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042051, HPA044083" Enhanced Approved Supported Nucleoplasm,Centrosome,Cytosol NA NA "Cluster 46: Basophils - DNA binding" "Cluster 77: Retina - Visual perception" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 5: Muller glia cells - Visual perception" Cytosol "Nucleoplasm, Centrosome" "HPA042051: AB_2732495, HPA044083: AB_2678802" "unprognostic (3.19e-2)" "unprognostic (2.66e-1)" "unprognostic (1.86e-1)" "unprognostic (1.25e-1)" "unprognostic (8.68e-2)" "unprognostic (1.76e-1)" "unprognostic (8.24e-3)" "unprognostic (5.21e-2)" "unprognostic (3.17e-1)" "unprognostic (2.63e-2)" "unprognostic (1.76e-1)" "unprognostic (2.78e-1)" "unprognostic (1.13e-1)" "unprognostic (8.42e-2)" 0.0 0.2 14.9 0.1 16.9 0.1 0.0 15.0 20.8 0.0 16.7 1.6 0.2 0.0 0.2 0.0 0.0 0.0 0.0 15.7 14.5 0.0 0.0 0.0 0.0 14.5 14.2 0.0 0.0 0.0 2.6 0.0 14.3 0.0 0.1 265.6 0.0 0.0 0.1 0.0 0.4 0.1 14.0 0.0 0.2 0.9 14.9 0.0 0.0 0.1 0.0 0.0 0.0 14.9 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 22.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 14.9 16.9 15.0 20.8 15.7 14.5 14.5 14.2 14.3 14.0 14.9 14.9 0.0 0.0 0.0 19.6 0.0 0.0 0.0 0.0 0.0 21.4 0.0 0.0 0.3 0.0 0.0 0.0 39.6 4.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 2.5 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 5.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.9 2.0 3148.2 0.0 5.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 90.9 0.0 0.0 0.0 0.2 0.2 0.0 0.0 20.0 0.0 0.0 0.0 0.0 RNASET2 "bA514O12.3, FLJ10907, RNASE6PL" ENSG00000026297 "Ribonuclease T2" O00584 6 166922113-166957191 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Immunity, Innate immunity" "Endonuclease, Hydrolase, Lyase, Nuclease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 490.2;Glandular and luminal cells: 761.3;Hofbauer cells: 382.2;Kupffer cells: 484.7;Macrophages: 418.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "THP-1: 497.9" "HPA029013, HPA066509" Approved "Secreted to blood" NA NA 15000000 "Cluster 52: Eosinophils - Transcription" "Cluster 50: Non-specific - Ribosome" "Cluster 43: THP-1 - Innate immune response" "Cluster 44: Endometrium - Transcription" "HPA029013: AB_10602922, HPA066509: AB_2685682" "unprognostic (4.18e-2)" "unprognostic (2.57e-1)" "unprognostic (1.44e-1)" "unprognostic (1.06e-1)" "unprognostic (4.13e-2)" "unprognostic (9.33e-2)" "unprognostic (1.76e-2)" "unprognostic (1.30e-1)" "unprognostic (1.15e-2)" "unprognostic (8.11e-2)" "unprognostic (1.79e-1)" "unprognostic (5.06e-2)" "prognostic unfavorable (1.70e-14)" "unprognostic (5.03e-2)" "unprognostic (7.34e-2)" "unprognostic (6.29e-2)" "unprognostic (1.01e-2)" 34.9 35.0 50.1 68.6 50.4 124.3 50.2 52.2 65.9 161.5 52.3 74.0 57.6 49.1 140.7 24.8 134.6 69.6 19.8 49.5 53.5 31.2 52.4 47.2 117.4 68.2 54.3 36.2 144.7 40.7 26.3 43.5 66.2 51.9 89.9 8.3 112.8 94.1 7.3 25.4 65.4 27.8 61.9 195.1 72.9 13.3 59.1 43.8 76.7 12.1 86.9 54.9 32.2 79.8 12.8 14.2 12.6 37.8 57.0 40.6 8.4 15.8 21.2 7.3 7.4 33.7 19.9 11.1 149.8 41.3 16.7 41.0 20.8 18.6 4.3 15.9 35.1 10.2 20.6 84.6 19.1 152.7 37.3 23.9 33.6 4.3 2.7 30.4 10.1 21.7 20.9 94.5 10.9 44.9 12.6 109.5 6.4 140.0 13.0 25.0 16.6 131.7 136.3 9.9 4.4 28.7 32.0 100.4 8.3 22.3 13.1 497.9 19.3 14.9 9.8 43.7 13.5 15.0 19.5 1.4 32.3 149.2 10.3 116.9 185.6 674.8 29.1 277.0 53.4 136.7 159.9 72.3 226.4 119.6 128.4 41.4 438.9 30.7 368.8 369.3 90.8 179.8 50.1 50.4 52.2 65.9 49.5 53.5 68.2 54.3 66.2 61.9 59.1 79.8 21.8 19.2 29.3 10.1 270.1 43.3 116.4 45.1 72.3 10.5 97.0 95.1 9.5 47.1 28.0 38.6 0.0 63.4 286.8 133.7 23.5 59.2 10.3 490.2 78.9 44.9 75.4 27.6 13.6 27.4 58.8 45.8 80.0 761.3 71.7 38.6 19.2 20.0 382.2 13.5 37.1 204.0 24.4 484.7 187.7 11.3 35.4 418.2 58.7 113.4 146.1 24.4 64.9 14.6 1.7 74.1 324.8 29.3 158.6 61.2 178.5 19.6 19.0 7.1 26.3 31.9 18.6 10.0 23.1 58.3 34.5 27.8 149.2 15.3 193.0 103.9 RNF13 RZF ENSG00000082996 "Ring finger protein 13" O43567 3 149812770-149962139 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 591.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 462.3" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA064784 Approved Supported Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 21: Non-specific - Transcription" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 4: Macrophages - Innate immune response" "Nucleoplasm, Vesicles" Cytosol "HPA064784: AB_2685350" "unprognostic (1.27e-1)" "unprognostic (2.32e-2)" "unprognostic (1.03e-1)" "unprognostic (1.93e-2)" "unprognostic (1.80e-1)" "unprognostic (9.64e-2)" "unprognostic (8.49e-2)" "unprognostic (4.36e-3)" "unprognostic (1.72e-1)" "unprognostic (1.25e-1)" "unprognostic (6.94e-3)" "unprognostic (1.13e-1)" "prognostic favorable (2.00e-8)" "unprognostic (2.95e-1)" "unprognostic (4.11e-2)" "unprognostic (2.17e-1)" "unprognostic (1.79e-1)" 48.2 41.2 58.1 40.4 95.2 19.9 53.9 88.1 91.5 33.6 63.7 35.0 28.9 33.3 57.2 32.6 30.2 40.6 34.4 55.0 77.3 67.9 73.8 64.1 38.0 101.8 83.9 35.6 36.1 52.3 18.3 64.1 100.8 46.6 37.1 40.4 75.5 39.3 36.5 32.5 30.5 36.9 85.6 53.0 34.3 25.2 75.9 32.0 64.0 42.6 33.2 42.3 28.9 131.0 60.6 39.4 24.4 29.0 92.2 55.2 40.3 32.2 86.2 32.3 47.4 33.4 84.4 26.6 48.7 42.0 58.7 58.0 37.5 41.5 42.9 34.1 24.6 35.8 17.3 31.2 61.5 35.0 41.8 59.9 73.1 26.5 71.8 37.3 37.0 24.9 10.1 49.7 28.0 34.5 26.2 18.8 16.8 58.6 29.1 19.0 26.7 108.5 54.2 29.6 12.6 37.6 28.5 39.9 110.3 19.2 79.2 34.0 37.8 40.8 16.5 45.6 23.4 89.9 61.9 51.5 35.9 30.1 23.6 98.2 130.1 106.5 37.4 153.8 48.8 51.9 41.5 44.8 93.1 48.4 38.0 42.4 462.3 46.3 207.8 68.3 48.7 104.5 58.1 95.2 88.1 91.5 55.0 77.3 101.8 83.9 100.8 85.6 75.9 131.0 100.9 109.0 72.3 78.7 55.3 73.5 68.2 84.3 74.0 44.5 54.5 51.1 27.3 48.6 68.1 47.8 29.2 101.2 61.9 30.2 43.0 63.0 2.5 32.5 34.5 69.4 20.3 32.4 122.1 70.6 83.5 84.8 31.6 39.7 60.8 14.6 80.3 53.7 201.2 21.9 98.8 27.7 67.1 183.9 173.7 6.7 76.1 177.6 103.2 92.8 93.5 98.5 38.1 115.6 591.2 58.7 33.6 88.0 62.4 71.9 38.5 71.5 40.4 37.2 92.1 76.3 55.5 23.6 32.5 52.3 72.5 52.5 49.8 38.2 27.7 55.8 RNF170 "ADSA, DKFZP564A022, SNAX1" ENSG00000120925 "Ring finger protein 170" Q96K19 8 42849637-42897290 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 89.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA050931, HPA054621" Uncertain NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 52: Non-specific - Transcription" "HPA050931: AB_2681279, HPA054621: AB_2682545" "unprognostic (3.06e-2)" "unprognostic (4.20e-1)" "unprognostic (9.54e-2)" "unprognostic (6.37e-2)" "unprognostic (4.59e-2)" "unprognostic (2.84e-2)" "unprognostic (1.04e-1)" "unprognostic (1.32e-1)" "unprognostic (3.23e-2)" "unprognostic (1.17e-1)" "unprognostic (2.59e-1)" "unprognostic (3.03e-2)" "unprognostic (1.61e-3)" "unprognostic (4.13e-3)" "unprognostic (2.00e-1)" "unprognostic (1.49e-1)" "unprognostic (2.13e-1)" 9.3 11.7 14.5 7.5 15.6 2.4 12.7 16.3 16.8 7.9 11.5 11.1 10.3 9.5 14.9 14.2 9.3 9.2 7.7 14.1 15.8 16.4 19.7 9.3 9.4 15.9 15.5 12.3 8.1 13.5 9.5 19.2 16.2 11.0 11.3 35.6 11.0 10.6 11.9 15.1 11.4 7.6 15.0 9.1 10.7 5.9 15.6 6.1 28.8 9.2 9.9 7.6 8.5 18.3 11.4 18.1 18.2 9.2 29.4 29.7 10.8 13.3 18.1 12.3 13.2 8.5 36.0 13.6 15.7 12.8 22.1 9.6 9.6 13.2 10.8 9.4 10.4 15.9 8.5 9.3 16.1 2.0 10.9 26.0 20.4 9.3 18.8 16.0 13.3 15.0 14.6 15.8 19.9 3.4 17.0 9.5 8.6 24.1 6.5 8.7 24.2 7.7 19.6 10.8 4.7 14.3 12.8 8.9 23.0 17.7 23.1 9.5 19.5 13.2 5.8 17.8 4.3 25.2 26.4 15.7 18.2 6.7 13.6 1.4 5.7 2.1 2.9 5.7 4.2 6.6 4.8 5.3 8.8 3.9 5.6 4.1 0.6 4.9 5.5 8.9 6.7 4.5 14.5 15.6 16.3 16.8 14.1 15.8 15.9 15.5 16.2 15.0 15.6 18.3 13.5 48.1 20.5 41.1 16.1 7.6 13.1 22.3 5.7 44.8 14.9 9.5 11.5 15.7 29.2 23.9 89.6 41.6 9.8 22.1 17.6 21.6 1.7 16.0 14.5 15.2 13.1 5.5 36.7 27.8 19.4 20.0 11.2 13.3 9.5 25.5 21.8 21.7 22.9 21.9 43.7 15.3 20.3 18.5 9.2 2.4 15.2 15.4 8.8 15.9 21.9 31.8 30.9 36.2 75.9 32.2 18.4 20.7 10.7 9.6 34.5 22.1 33.3 72.1 13.1 23.9 12.1 14.9 19.3 12.5 11.5 31.2 12.8 25.7 16.6 12.2 RNF216 "TRIAD3, UBCE7IP1, ZIN" ENSG00000011275 "Ring finger protein 216" Q9NWF9 7 5620047-5781696 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Ubl conjugation pathway" Transferase "Disease variant, Hypogonadotropic hypogonadism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 145.5;Late spermatids: 257.6;Spermatocytes: 159.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018955, HPA021123" Supported Supported Nucleoplasm,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 43: Testis - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Cytosol Nucleoplasm "HPA018955: AB_1858500, HPA021123: AB_1858501" "unprognostic (3.31e-2)" "unprognostic (4.24e-2)" "unprognostic (1.28e-2)" "unprognostic (1.58e-2)" "unprognostic (1.81e-2)" "unprognostic (1.56e-1)" "prognostic unfavorable (2.26e-4)" "unprognostic (2.35e-1)" "unprognostic (2.40e-1)" "unprognostic (1.40e-2)" "prognostic favorable (6.24e-5)" "unprognostic (2.88e-2)" "unprognostic (9.01e-2)" "unprognostic (3.49e-1)" "unprognostic (1.73e-2)" "unprognostic (1.06e-2)" "unprognostic (3.69e-3)" 14.3 12.3 14.3 12.8 15.9 15.6 13.1 12.6 14.6 13.2 10.0 25.5 8.1 21.9 8.2 12.3 15.8 8.7 21.7 13.8 17.5 10.0 10.1 12.8 17.0 14.9 15.4 16.5 14.9 13.9 15.4 7.7 14.8 14.6 5.8 7.2 11.4 13.7 19.6 13.3 17.9 15.0 12.8 19.2 14.6 30.1 16.2 12.8 12.7 11.9 11.5 16.4 10.9 14.3 22.0 23.6 17.0 32.8 21.6 14.6 11.5 20.7 19.3 17.6 15.8 16.7 12.3 17.3 11.4 22.0 38.7 17.1 13.6 15.3 10.3 11.4 19.3 12.5 13.6 18.0 27.7 19.5 25.3 21.4 20.4 16.2 14.6 18.4 15.0 19.2 28.4 12.9 18.9 35.2 8.8 44.7 25.7 13.1 20.0 26.1 23.4 12.2 13.9 13.9 14.1 25.3 11.8 33.9 13.2 15.3 14.2 28.2 20.5 24.9 39.9 25.2 22.8 11.4 9.0 16.0 19.6 21.7 37.4 3.5 7.7 24.2 10.1 8.3 9.4 8.3 9.3 8.7 6.3 8.8 10.9 11.3 13.2 12.7 8.7 7.1 8.3 6.9 14.3 15.9 12.6 14.6 13.8 17.5 14.9 15.4 14.8 12.8 16.2 14.3 33.4 6.4 23.9 34.9 33.6 16.6 20.8 11.9 15.9 36.4 16.1 17.8 33.3 8.6 13.6 12.9 52.1 14.1 47.7 10.3 25.4 17.6 145.5 14.6 33.7 29.7 6.0 8.8 50.2 13.7 12.9 26.7 16.3 16.9 19.6 34.0 26.4 15.1 22.9 28.6 61.7 15.4 6.1 23.0 29.3 257.6 37.3 23.1 12.4 49.6 37.0 30.2 56.7 46.3 64.2 15.6 7.0 30.1 20.3 24.2 13.0 14.9 13.7 48.5 26.3 46.0 30.0 159.8 124.2 12.9 16.2 15.2 40.2 22.8 11.8 15.2 ROBO3 "FLJ21044, HGPPS, HGPS, RBIG1" ENSG00000154134 "Roundabout guidance receptor 3" Q96MS0 11 124865432-124881471 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Chemotaxis, Differentiation, Neurogenesis" "Developmental protein, Receptor" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "ovary: 6.4" "Cell type enhanced" "Detected in many" "Astrocytes: 32.3;Muller glia cells: 45.3" "Cancer enhanced" "Detected in many" "glioma: 5.0" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 12 "AF22: 18.4" "Region enhanced" "Detected in single" "cerebral cortex: 2.1" "Low region specificity" "Detected in many" HPA071053 Approved "Vesicles,Plasma membrane" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 12: NES - Nervous system development" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane" Vesicles "HPA071053: " "unprognostic (1.30e-1)" "unprognostic (2.17e-1)" "unprognostic (4.95e-3)" "unprognostic (3.42e-2)" "unprognostic (3.84e-2)" "unprognostic (6.25e-2)" "unprognostic (6.95e-3)" "unprognostic (9.65e-2)" "unprognostic (1.56e-2)" "unprognostic (1.18e-1)" "unprognostic (1.32e-1)" "unprognostic (7.15e-2)" "unprognostic (3.75e-8)" "unprognostic (7.27e-3)" "unprognostic (2.21e-1)" "unprognostic (1.47e-1)" "unprognostic (4.91e-3)" 2.8 1.8 0.5 0.0 0.3 0.2 1.9 0.0 3.2 0.7 0.0 1.3 0.3 0.8 0.0 0.7 2.0 0.0 1.8 0.7 0.2 1.6 0.4 1.1 0.1 0.9 0.9 6.4 0.7 0.0 0.8 0.2 0.2 1.4 0.0 0.2 1.2 0.0 0.5 0.7 0.9 0.8 0.2 1.6 0.6 1.2 1.7 0.0 1.4 0.0 0.0 0.7 1.2 0.9 0.0 0.0 18.4 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.1 0.3 0.0 1.3 0.0 0.3 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 1.1 0.0 0.0 1.5 0.2 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.7 0.2 0.0 0.1 0.0 0.0 0.4 0.3 0.0 0.1 0.2 0.3 0.0 0.1 0.1 0.0 0.6 0.9 0.0 0.9 0.2 0.0 0.0 0.0 0.4 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.5 0.3 0.0 3.2 0.7 0.2 0.9 0.9 0.2 0.2 1.7 0.9 13.2 0.0 7.3 32.3 0.4 2.9 14.5 16.2 4.0 1.9 5.9 10.9 2.7 1.5 5.9 12.9 0.0 0.2 8.5 2.1 0.0 9.3 0.4 0.4 0.5 11.4 3.5 2.1 6.9 0.8 0.2 19.0 0.5 0.7 8.9 19.0 7.5 0.3 1.6 0.0 2.3 2.4 10.2 1.6 20.1 0.6 13.4 8.0 3.6 11.2 1.6 45.3 8.2 4.5 9.2 1.2 2.5 8.2 0.7 8.2 1.0 0.8 0.6 2.1 0.0 14.3 4.4 10.1 10.8 2.3 1.0 0.1 3.6 3.5 2.7 6.5 ROGDI FLJ22386 ENSG00000067836 "Rogdi atypical leucine zipper" Q9GZN7 16 4796968-4802880 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Amelogenesis imperfecta, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 105.6" "Cell type enhanced" "Detected in all" "Bipolar cells: 179.2;Rod photoreceptor cells: 149.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 6 "classical monocyte: 74.6;intermediate monocyte: 62.7;myeloid DC: 61.5;non-classical monocyte: 61.8;plasmacytoid DC: 34.5" "Group enriched" "Detected in all" 6 "dendritic cells: 61.5;monocytes: 74.6" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041000 Uncertain NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 56: Bipolar cells - Visual perception" "HPA041000: AB_10794077" "unprognostic (1.74e-3)" "unprognostic (1.98e-3)" "unprognostic (1.25e-1)" "unprognostic (1.01e-2)" "unprognostic (1.68e-1)" "unprognostic (1.95e-1)" "unprognostic (3.13e-1)" "unprognostic (3.79e-3)" "unprognostic (3.22e-2)" "unprognostic (1.21e-1)" "prognostic favorable (9.71e-4)" "unprognostic (5.24e-2)" "prognostic favorable (2.67e-5)" "unprognostic (1.71e-1)" "unprognostic (7.16e-2)" "unprognostic (2.17e-1)" "unprognostic (3.08e-2)" 7.5 24.1 82.9 11.6 84.5 78.0 7.3 81.3 105.6 8.8 64.3 17.6 24.8 7.5 6.6 18.1 14.5 14.4 44.2 91.4 83.9 19.3 19.7 15.5 8.6 84.0 84.9 5.9 22.9 26.4 18.2 7.9 80.9 19.0 7.6 61.9 25.3 16.6 63.1 6.5 21.4 11.3 79.4 15.6 21.1 8.2 96.8 10.1 4.6 32.9 8.7 11.2 6.4 97.6 13.5 18.8 9.5 42.4 12.2 6.2 36.4 9.4 4.6 8.2 3.6 12.5 15.3 5.9 15.1 19.9 5.3 26.7 9.9 28.7 3.2 4.8 13.3 8.0 28.9 28.1 19.8 10.4 6.5 8.3 11.7 12.4 8.3 21.6 14.5 11.5 5.7 3.5 14.1 74.9 9.4 51.0 15.3 15.4 14.2 30.1 26.1 30.1 19.8 18.1 55.3 24.5 38.6 42.4 9.9 11.9 50.9 40.8 22.3 7.3 17.0 52.5 6.5 14.2 17.0 5.2 8.6 40.0 6.5 10.5 74.6 8.1 2.1 62.7 6.6 2.5 5.4 4.9 61.5 2.8 4.7 5.5 6.7 6.7 61.8 34.5 6.1 38.0 82.9 84.5 81.3 105.6 91.4 83.9 84.0 84.9 80.9 79.4 96.8 97.6 7.0 19.2 7.8 17.3 6.7 5.1 28.0 84.4 32.5 179.2 23.0 22.5 58.1 21.5 36.7 27.6 110.5 46.9 11.5 23.4 39.2 22.2 30.3 17.6 8.5 12.0 52.0 38.7 33.2 16.0 73.4 15.9 11.7 7.2 5.7 9.8 24.3 19.7 64.8 25.2 19.2 29.7 69.2 28.7 29.0 57.0 6.8 31.0 12.4 10.3 77.0 102.5 6.2 7.5 90.2 13.5 23.7 19.2 4.6 12.7 65.7 80.8 21.3 149.7 6.6 8.2 15.3 6.5 20.7 24.8 5.8 30.6 9.5 64.7 23.1 22.3 ROM1 "ROM, TSPAN23" ENSG00000149489 "Retinal outer segment membrane protein 1" Q03395 11 62611722-62615116 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion, Sensory transduction, Vision" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 18 "retina: 1186.9" "Cell type enriched" "Detected in many" 5 "Rod photoreceptor cells: 3239.7" "Cancer enriched" "Detected in all" 6 "glioma: 14.9" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "NK-cell: 2.7" "Group enriched" "Detected in many" 4 "NK-cells: 2.7;T-cells: 1.2" "Cell line enhanced" "Detected in many" "HSkMC: 25.2;U-266/84: 31.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA028910, HPA073279" Enhanced Approved "Plasma membrane,Cytosol" No No "Cluster 22: NK-cells - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 16: U-266 - Nucleosome" "Cluster 46: Photoreceptor cells - Phototransduction" "Plasma membrane, Cytosol" "HPA028910: AB_2672824, HPA073279: " "unprognostic (1.54e-2)" "unprognostic (1.37e-2)" "unprognostic (4.24e-2)" "unprognostic (1.11e-1)" "unprognostic (1.65e-1)" "unprognostic (2.02e-1)" "unprognostic (4.05e-1)" "prognostic favorable (2.20e-4)" "unprognostic (2.20e-1)" "unprognostic (9.87e-2)" "unprognostic (7.65e-3)" "unprognostic (3.50e-2)" "prognostic unfavorable (2.85e-6)" "unprognostic (2.61e-1)" "unprognostic (4.65e-1)" "unprognostic (1.02e-1)" "unprognostic (7.24e-2)" 12.8 7.9 57.9 2.2 60.5 1.2 9.3 56.8 67.4 9.1 48.1 9.8 1.8 7.7 4.7 7.6 10.7 4.6 8.1 54.5 59.0 7.0 7.1 6.0 2.5 67.4 61.0 13.5 3.6 5.2 7.0 1.4 62.1 8.2 2.6 1186.9 4.2 5.0 3.3 5.4 5.3 5.4 60.0 7.5 7.0 6.2 63.1 1.6 6.0 3.7 2.5 9.6 7.3 62.1 3.2 1.9 3.1 6.6 4.5 22.0 0.6 2.1 3.7 4.3 2.8 0.9 5.3 3.0 15.9 12.2 2.0 4.1 1.5 4.2 1.1 5.3 3.0 3.1 8.6 4.0 13.0 1.1 0.9 25.2 5.9 4.5 9.1 15.1 7.0 1.2 4.0 6.5 9.1 8.3 1.7 2.3 0.8 1.7 5.9 1.6 2.6 19.1 5.0 1.8 3.3 5.1 5.0 5.8 2.5 0.5 8.1 1.4 8.3 7.2 2.7 8.3 2.5 2.9 31.9 2.4 14.2 3.1 1.5 0.0 0.4 0.3 0.3 0.1 0.9 0.2 1.2 0.3 0.2 0.3 0.5 0.6 0.1 2.7 0.4 0.3 0.4 0.5 57.9 60.5 56.8 67.4 54.5 59.0 67.4 61.0 62.1 60.0 63.1 62.1 19.9 0.0 4.4 4.9 0.6 3.7 5.7 5.0 7.4 356.6 3.8 7.2 2.5 2.8 2.3 5.5 594.2 1.0 0.6 2.4 1.9 1.6 2.0 1.0 4.1 31.3 4.2 0.0 0.2 3.1 0.2 4.1 1.1 1.0 1.3 1.2 21.8 1.7 1.1 171.6 0.5 2.8 0.0 1.9 0.8 7.9 19.0 1.2 3.6 1.9 1.3 516.9 1.0 1.0 6.5 2.1 2.5 5.7 0.6 3.1 3.1 4.7 2.7 3239.7 0.0 2.5 4.3 1.6 5.1 5.3 1.0 0.7 1.5 4.0 2.9 3.1 ROR1 NTRKR1 ENSG00000185483 "Receptor tyrosine kinase like orphan receptor 1" Q01973 1 63774017-64181498 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Wnt signaling pathway" "Kinase, Receptor, Transferase" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "parathyroid gland: 26.9" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 51.3;Astrocytes: 81.0;Inhibitory neurons: 69.7;Microglial cells: 36.5;Oligodendrocytes: 109.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 40.5;ASC TERT1: 50.3;CACO-2: 36.8;HHSteC: 38.3;HSkMC: 41.6;NTERA-2: 43.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "Intracellular and membrane" NA NA 7700000 "Cluster 40: NK-cells - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (5.15e-2)" "unprognostic (1.19e-2)" "unprognostic (3.65e-2)" "unprognostic (1.03e-2)" "unprognostic (6.24e-2)" "unprognostic (1.61e-1)" "unprognostic (7.11e-3)" "unprognostic (1.41e-1)" "unprognostic (4.06e-1)" "unprognostic (3.84e-1)" "unprognostic (3.20e-2)" "unprognostic (2.02e-2)" "unprognostic (3.64e-3)" "unprognostic (1.48e-2)" "unprognostic (1.52e-1)" "unprognostic (5.87e-2)" "unprognostic (5.15e-2)" 4.4 1.1 0.6 2.2 1.4 0.4 3.7 3.0 0.8 7.5 4.6 4.5 2.2 7.1 1.4 5.2 2.5 5.2 7.5 0.7 0.6 2.3 0.5 7.0 1.2 0.7 0.9 8.3 5.5 26.9 0.5 3.1 0.5 5.4 4.0 1.5 1.2 6.4 2.3 2.3 1.7 7.7 0.3 3.2 6.4 1.5 1.2 2.5 1.4 1.6 1.1 4.2 2.3 1.1 15.5 12.2 5.9 0.8 40.5 50.3 4.0 2.9 8.3 1.6 4.3 36.8 4.9 0.3 6.6 7.2 2.9 3.2 0.1 2.9 1.1 0.0 3.7 0.0 1.6 0.5 38.3 0.0 0.0 41.6 10.9 21.7 25.2 8.4 0.7 0.5 0.0 0.3 11.0 0.2 0.2 0.1 43.0 11.3 6.1 0.2 0.2 9.8 8.7 0.3 3.4 13.6 0.8 0.2 6.4 19.9 0.1 0.0 8.4 3.3 5.7 23.0 6.2 0.0 0.0 0.0 0.4 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.2 0.0 0.0 0.6 1.4 3.0 0.8 0.7 0.6 0.7 0.9 0.5 0.3 1.2 1.1 1.1 51.3 10.5 81.0 1.8 3.8 2.2 0.5 29.0 4.7 3.0 2.0 11.4 1.5 1.3 1.8 0.0 0.2 0.1 1.3 0.0 5.6 9.6 1.2 9.2 1.8 21.5 0.0 11.6 15.2 1.0 14.5 16.8 1.9 0.0 1.1 0.7 0.0 7.6 0.0 69.7 2.2 2.0 0.6 4.9 8.1 27.7 0.5 3.6 36.5 0.0 5.3 0.0 3.5 109.9 15.3 0.8 14.7 0.1 1.4 0.0 3.4 0.8 0.3 6.6 6.8 8.5 1.4 1.8 11.5 4.5 0.3 0.2 0.3 3.3 0.8 RORB "NR1F2, ROR-BETA, RZRB" ENSG00000198963 "RAR related orphan receptor B" Q92753 9 74497335-74693177 "Disease related genes, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors" "Biological rhythms, Sensory transduction, Transcription, Transcription regulation, Vision" "Activator, Developmental protein, DNA-binding, Receptor" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 18.0;retina: 55.6" "Cell type enhanced" "Detected in many" "Astrocytes: 393.7;Endometrial stromal cells: 436.8;Excitatory neurons: 190.0;Horizontal cells: 1399.8;Muller glia cells: 390.7;Rod photoreceptor cells: 190.3" "Group enriched" "Detected in some" 5 "glioma: 2.1;prostate cancer: 2.3" "Region enhanced" "Detected in many" "cerebral cortex: 18.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "HHSteC: 22.5;HSkMC: 12.4;JURKAT: 23.3;MOLT-4: 6.9;SH-SY5Y: 13.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008393 Uncertain Approved Nucleoplasm NA NA "Cluster 77: Retina - Visual perception" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 62: Horizontal cells - Visual perception" Nucleoplasm "HPA008393: AB_1079830" "unprognostic (6.89e-3)" "unprognostic (4.06e-3)" "unprognostic (1.38e-1)" "unprognostic (3.97e-1)" "unprognostic (1.34e-1)" "unprognostic (1.05e-3)" "unprognostic (1.28e-1)" "unprognostic (1.18e-2)" "unprognostic (1.07e-1)" "unprognostic (3.07e-1)" "unprognostic (3.52e-1)" "unprognostic (5.46e-2)" "unprognostic (8.81e-8)" "unprognostic (5.97e-3)" "unprognostic (2.17e-2)" "unprognostic (2.26e-2)" "unprognostic (4.00e-2)" 1.1 3.4 0.0 0.1 1.3 0.0 0.3 0.0 18.0 9.8 0.0 0.2 0.1 3.9 0.0 0.4 0.3 1.7 1.6 3.7 0.7 0.5 0.0 0.6 0.0 0.0 0.3 0.2 0.1 0.3 1.7 2.0 0.0 4.6 0.3 55.6 0.1 5.0 0.0 0.2 0.1 0.3 0.0 0.0 0.3 0.6 0.4 0.4 0.3 0.1 0.3 0.7 0.8 5.1 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 22.5 0.0 0.7 12.4 0.0 0.0 0.0 0.0 0.0 23.3 0.0 3.6 0.0 0.1 6.9 0.0 0.9 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.3 13.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.0 1.1 0.0 0.0 0.0 0.5 3.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 18.0 3.7 0.7 0.0 0.3 0.0 0.0 0.4 5.1 0.1 0.0 4.8 393.7 0.4 1.7 0.8 0.0 6.8 156.4 0.4 0.6 14.1 0.0 0.0 0.0 120.9 0.2 2.7 0.1 0.0 0.0 6.6 11.9 436.8 4.2 0.0 0.0 190.0 0.0 0.4 10.7 0.0 6.9 1.3 0.2 0.7 0.0 0.6 1399.8 6.4 0.0 0.0 0.3 2.1 1.9 0.0 1.8 1.8 10.3 0.1 390.7 1.0 12.5 28.6 0.1 0.0 0.0 0.8 2.8 0.0 8.9 0.7 190.3 0.0 8.7 9.9 3.0 0.7 1.4 0.4 0.1 3.0 0.3 0.1 0.9 RP1 "DCDC4A, ORP1" ENSG00000104237 "RP1 axonemal microtubule associated" P56715 8 54509422-54871720 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cilium biogenesis/degradation, Sensory transduction, Vision" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 23 "retina: 236.4" "Group enriched" "Detected in some" 4 "Cone photoreceptor cells: 333.6;Rod photoreceptor cells: 1115.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "EFO-21: 1.6;HDLM-2: 5.2;hTERT-RPE1: 2.0;RPTEC TERT1: 10.2;U-2197: 2.3" "Not detected" "Not detected" "Region enhanced" "Detected in single" "midbrain: 1.3" HPA042257 Enhanced NA NA "Cluster 79: Retina - Phototransduction" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA042257: AB_10797385" "unprognostic (3.19e-3)" "unprognostic (2.63e-3)" "unprognostic (1.16e-1)" "unprognostic (1.58e-2)" "unprognostic (1.70e-1)" "unprognostic (9.16e-3)" "unprognostic (6.24e-2)" "unprognostic (4.56e-2)" "unprognostic (4.13e-5)" "unprognostic (2.48e-1)" "unprognostic (2.16e-5)" "unprognostic (8.92e-2)" "unprognostic (6.18e-2)" "unprognostic (1.89e-2)" "unprognostic (8.96e-2)" 0.1 0.0 0.1 0.0 0.0 0.0 0.6 0.1 0.2 0.4 0.0 0.0 0.0 0.1 0.0 0.0 10.1 0.0 0.0 0.1 0.0 0.7 0.1 3.5 0.0 0.4 0.3 0.1 0.0 0.0 0.0 0.3 0.1 0.0 0.0 236.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.5 1.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.0 1.6 0.0 0.1 0.0 0.7 0.0 0.0 5.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 2.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 10.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.1 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.2 0.1 0.0 0.4 0.3 0.1 0.0 0.1 0.1 0.5 16.0 4.8 0.0 0.0 0.0 0.0 1.2 0.0 72.5 3.0 1.4 0.4 0.0 31.1 5.5 333.6 0.0 0.0 0.0 3.9 0.0 0.3 81.9 0.4 10.3 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.9 0.0 0.0 0.0 0.0 0.0 32.0 0.2 0.0 2.0 0.0 0.0 0.0 0.0 0.5 1.8 0.0 0.0 130.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.2 149.0 1115.8 0.0 0.0 0.4 3.2 2.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 RP1L1 DCDC4B ENSG00000183638 "RP1 like 1" Q8IWN7 8 10606349-10712187 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cilium biogenesis/degradation, Sensory transduction, Vision" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in single" 114 "retina: 44.1" "Group enriched" "Detected in some" 20 "Cone photoreceptor cells: 93.8;Rod photoreceptor cells: 68.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA024686, HPA024744" Enhanced NA NA "Cluster 79: Retina - Phototransduction" "Cluster 9: Photoreceptor cells - Phototransduction" "HPA024686: AB_2671650, HPA024744: AB_2671668" "unprognostic (3.27e-1)" "unprognostic (9.97e-2)" "unprognostic (1.24e-1)" "unprognostic (6.41e-2)" "unprognostic (2.04e-1)" "unprognostic (1.36e-1)" "unprognostic (2.37e-1)" "unprognostic (1.98e-5)" "unprognostic (3.57e-1)" "unprognostic (5.22e-2)" "unprognostic (2.08e-4)" "unprognostic (8.52e-2)" "unprognostic (5.77e-2)" "unprognostic (6.29e-2)" "unprognostic (1.70e-1)" "unprognostic (2.02e-2)" "unprognostic (2.82e-1)" 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 44.1 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.3 0.0 0.6 0.8 0.1 0.0 4.0 0.2 0.3 0.8 0.0 0.0 0.0 93.8 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.8 0.0 0.0 0.4 0.2 0.0 0.3 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.3 0.0 0.0 0.6 0.0 0.0 0.1 3.3 0.0 0.5 0.6 0.1 0.0 0.4 0.0 0.7 0.0 0.1 0.0 68.0 0.0 1.6 0.5 0.0 0.5 0.0 0.9 0.0 0.1 0.1 0.0 1.0 RP2 "NM23-H10, NME10, TBCCD2" ENSG00000102218 "RP2 activator of ARL3 GTPase" O75695 X 46837043-46882358 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Protein transport, Transport" "GTPase activation" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 49.5" "Cell type enhanced" "Detected in many" "Kupffer cells: 62.8;Langerhans cells: 72.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000234, HPA000909" Uncertain Approved "Nucleoplasm,Nuclear bodies,Plasma membrane" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 28: BEWO - Transcription regulation" "Cluster 41: Macrophages - Immune response" "Nucleoplasm, Plasma membrane" "Nuclear bodies" "HPA000234: AB_1079831, HPA000909: AB_2666140" "unprognostic (2.26e-1)" "unprognostic (6.01e-3)" "unprognostic (2.79e-2)" "unprognostic (2.98e-1)" "unprognostic (1.69e-1)" "unprognostic (3.40e-1)" "prognostic unfavorable (7.97e-4)" "unprognostic (2.58e-2)" "unprognostic (9.76e-3)" "unprognostic (3.10e-2)" "unprognostic (3.79e-3)" "unprognostic (9.75e-2)" "unprognostic (6.15e-3)" "unprognostic (2.96e-2)" "unprognostic (9.66e-2)" "unprognostic (1.61e-1)" "unprognostic (4.28e-3)" 10.9 8.9 1.9 15.6 2.3 49.5 7.2 2.6 2.3 7.9 3.6 10.1 10.6 6.9 4.0 12.9 6.8 12.7 4.8 1.7 2.7 6.7 13.2 11.8 12.9 3.3 2.8 6.5 4.6 7.4 1.7 25.2 3.5 6.7 10.5 4.2 4.4 5.3 2.0 5.3 11.0 9.0 3.5 13.2 8.1 4.0 2.3 9.8 6.1 3.6 11.2 10.4 4.2 4.6 21.8 10.3 20.4 11.0 15.7 19.4 48.0 27.4 21.5 23.8 23.9 44.6 18.2 25.8 10.7 29.3 20.1 14.0 19.8 20.0 32.1 11.5 11.5 13.9 11.7 10.7 17.9 29.2 46.4 15.1 13.0 18.8 10.1 13.3 30.5 11.4 6.2 13.1 27.0 1.9 18.1 26.8 12.5 14.8 19.5 22.9 27.9 13.8 15.3 22.0 7.4 10.0 24.4 14.9 12.4 36.2 16.8 27.1 27.1 18.3 13.6 29.1 9.8 4.9 6.8 15.4 9.5 20.4 19.5 62.6 22.6 35.5 6.1 30.8 5.0 10.3 4.9 5.3 22.6 9.6 6.0 5.7 43.5 7.6 36.3 7.6 6.1 12.2 1.9 2.3 2.6 2.3 1.7 2.7 3.3 2.8 3.5 3.5 2.3 4.6 9.6 9.6 7.4 3.9 18.9 15.8 3.2 6.1 15.4 3.1 7.8 6.1 1.7 7.2 5.1 9.2 2.1 23.2 12.0 28.6 0.0 4.7 2.8 15.8 14.5 8.6 3.6 10.3 3.1 5.3 6.4 10.3 12.8 14.9 12.0 4.0 12.5 20.1 24.3 0.0 4.0 9.4 2.0 62.8 72.9 1.7 5.6 44.7 21.4 6.5 36.6 3.6 6.2 12.1 5.9 11.6 13.4 5.7 13.2 8.2 9.8 3.6 14.5 5.5 6.6 7.7 10.5 7.8 4.6 36.4 14.9 38.2 11.4 4.7 10.5 13.6 RP9 PAP-1 ENSG00000164610 "RP9 pre-mRNA splicing factor" Q8TA86 7 33094797-33109404 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031523, HPA050778" Uncertain Enhanced Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 37: B-cells - Transcription" "Cluster 47: Non-specific - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 57: B-cells - Immune response" Nucleoplasm "Vesicles, Cytosol" "HPA031523: AB_10603235, HPA050778: AB_2681233" "unprognostic (1.12e-1)" "unprognostic (1.80e-1)" "unprognostic (1.07e-2)" "unprognostic (1.82e-1)" "unprognostic (6.65e-2)" "unprognostic (1.84e-1)" "prognostic unfavorable (2.58e-4)" "unprognostic (6.71e-2)" "unprognostic (6.22e-2)" "unprognostic (7.53e-2)" "unprognostic (7.03e-3)" "unprognostic (1.25e-1)" "prognostic unfavorable (2.65e-5)" "unprognostic (4.19e-2)" "unprognostic (2.63e-2)" "unprognostic (2.70e-1)" "unprognostic (1.61e-1)" 12.6 15.0 26.3 8.7 26.1 21.6 12.6 28.0 51.2 17.0 26.7 16.7 9.0 14.4 15.5 10.1 14.0 6.2 29.2 25.8 26.3 17.2 13.8 12.0 15.6 26.6 26.3 16.2 20.2 10.5 10.3 10.2 26.7 14.4 9.8 16.7 11.5 11.7 36.3 13.8 15.9 8.4 25.8 20.8 13.5 18.1 26.9 13.8 16.0 34.3 16.7 14.3 13.1 27.4 20.9 28.8 29.7 34.1 18.5 17.2 14.3 26.4 21.6 28.9 23.0 25.6 14.6 26.2 17.0 21.1 35.4 20.4 36.4 22.0 36.8 11.9 25.1 19.2 22.8 24.4 32.4 26.0 13.0 17.5 20.2 32.8 64.5 23.3 24.0 27.1 35.2 23.0 29.1 42.6 27.7 69.6 25.4 27.2 21.9 28.2 26.4 17.1 21.1 19.3 28.7 39.5 18.7 39.6 46.2 35.1 20.8 35.0 19.4 28.4 40.9 25.6 42.8 38.1 37.2 51.7 20.0 36.3 56.1 21.9 12.0 21.6 15.2 9.8 14.1 57.8 16.3 17.4 13.2 77.3 19.1 18.0 2.0 15.7 12.5 28.4 15.8 8.8 26.3 26.1 28.0 51.2 25.8 26.3 26.6 26.3 26.7 25.8 26.9 27.4 21.3 12.8 10.1 4.9 35.6 21.0 15.1 11.3 29.0 15.8 17.7 27.9 41.7 17.2 10.9 14.7 14.6 20.2 16.8 12.6 21.5 16.0 5.6 14.6 28.2 24.1 10.2 19.4 6.5 15.8 20.0 20.4 20.4 16.6 3.8 26.8 15.4 16.4 18.4 8.4 7.5 19.3 24.4 10.1 14.9 3.2 18.0 12.0 23.2 5.6 10.1 21.9 21.6 3.0 8.7 14.6 8.0 16.1 24.4 22.9 16.1 18.6 8.5 16.4 26.3 19.4 30.3 31.6 54.3 24.4 18.0 10.4 19.9 22.9 18.4 12.0 RPE65 "BCO3, LCA2, rd12, RP20" ENSG00000116745 "Retinoid isomerohydrolase RPE65" Q16518 1 68428822-68449954 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Sensory transduction, Vision" "Hydrolase, Isomerase" "Disease variant, FDA approved drug targets, Leber congenital amaurosis, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 5.2;choroid plexus: 4.5;retina: 8.4;seminal vesicle: 4.5" "Group enriched" "Detected in some" 6 "Cone photoreceptor cells: 10.4;Rod photoreceptor cells: 17.8" "Group enriched" "Detected in some" 10 "glioma: 5.8;head and neck cancer: 1.5" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 3.4;PC-3: 5.6;U-2 OS: 1.3" "Group enriched" "Detected in many" 4 "amygdala: 3.2;basal ganglia: 2.5;cerebral cortex: 3.9;hippocampal formation: 2.5" "Low region specificity" "Detected in many" NA NA "Cluster 77: Retina - Visual perception" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 46: Photoreceptor cells - Phototransduction" "unprognostic (1.59e-1)" "unprognostic (1.88e-1)" "unprognostic (3.15e-1)" "prognostic favorable (9.75e-4)" "unprognostic (4.55e-2)" "unprognostic (5.91e-2)" "unprognostic (6.59e-4)" "unprognostic (2.98e-2)" "unprognostic (1.57e-1)" "unprognostic (8.24e-2)" "unprognostic (3.21e-4)" "unprognostic (2.11e-1)" "unprognostic (2.05e-1)" "unprognostic (3.48e-2)" "unprognostic (8.40e-3)" 0.0 0.0 1.5 0.0 0.8 0.0 0.4 0.5 0.5 0.2 4.5 0.1 0.2 0.6 0.1 0.3 0.3 0.1 0.0 0.7 3.0 0.0 0.0 0.0 0.0 1.1 5.2 0.0 0.0 0.0 0.0 0.0 2.0 1.8 0.1 8.4 0.1 4.5 0.0 0.0 0.0 0.2 1.7 0.1 0.3 0.1 4.0 0.0 0.0 0.0 0.0 0.2 0.0 1.3 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.8 0.5 0.5 0.7 3.0 1.1 5.2 2.0 1.7 4.0 1.3 0.0 0.0 0.0 2.3 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.3 0.1 0.0 0.0 0.0 10.4 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.0 0.0 1.3 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 17.8 0.0 0.0 0.2 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 RPGR "COD1, CORDX1, CRD, RP15, RP3" ENSG00000156313 "Retinitis pigmentosa GTPase regulator" Q92834 X 38269163-38327544 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Cilium biogenesis/degradation, Sensory transduction, Vision" "Guanine-nucleotide releasing factor" "Cancer-related genes, Ciliopathy, Cone-rod dystrophy, Deafness, Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 146.1;Hepatic stellate cells: 121.7;Respiratory ciliated cells: 119.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 14.6" "Lineage enriched" "Detected in all" 5 "granulocytes: 14.6" "Cell line enhanced" "Detected in many" "HL-60: 31.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001593, HPA073455" Approved Supported "Golgi apparatus" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 49: Ciliated cells - Cilium organization" "Golgi apparatus" "HPA001593: AB_1079835, HPA073455: AB_2686603" "unprognostic (3.22e-2)" "unprognostic (1.16e-2)" "unprognostic (5.04e-2)" "unprognostic (1.08e-1)" "unprognostic (3.20e-1)" "unprognostic (9.94e-2)" "unprognostic (3.46e-2)" "unprognostic (6.32e-2)" "unprognostic (2.04e-1)" "unprognostic (1.37e-1)" "unprognostic (1.96e-3)" "unprognostic (1.42e-1)" "unprognostic (1.03e-6)" "unprognostic (1.93e-1)" "unprognostic (7.59e-2)" "unprognostic (8.96e-3)" "unprognostic (1.61e-3)" 19.2 5.7 4.7 4.4 4.6 12.2 16.8 5.2 5.5 10.2 15.5 9.1 3.0 11.6 2.5 5.5 15.0 5.5 9.8 4.6 6.3 6.2 3.7 14.8 3.7 7.6 7.0 6.2 7.5 2.6 32.9 3.7 5.8 6.9 3.6 12.1 5.2 2.6 12.1 6.0 9.4 4.5 6.6 5.1 6.8 8.1 5.3 4.7 9.7 3.7 3.2 8.7 8.2 5.4 4.7 6.0 3.4 3.2 3.6 5.2 2.7 5.8 6.5 4.1 4.8 2.7 2.6 7.1 1.8 3.9 3.4 4.4 4.1 1.8 5.6 7.5 7.9 2.5 2.7 5.5 3.3 31.8 5.8 8.0 2.4 8.7 9.2 1.6 18.9 7.5 3.3 0.0 5.7 1.5 9.1 17.7 8.7 2.9 7.5 6.8 11.7 6.4 3.6 3.0 2.7 5.2 6.4 2.6 7.2 5.1 1.7 5.4 22.4 4.5 8.0 10.7 7.2 1.9 3.9 6.0 10.6 6.1 6.2 1.3 2.6 5.9 1.3 2.4 2.9 1.9 1.5 1.8 2.6 1.5 2.2 1.8 14.6 1.7 2.0 1.8 1.9 1.8 4.7 4.6 5.2 5.5 4.6 6.3 7.6 7.0 5.8 6.6 5.3 5.4 75.2 16.0 32.6 21.2 21.8 7.9 13.5 6.6 7.4 29.5 8.8 8.8 8.0 8.6 18.0 1.8 62.6 5.8 14.0 12.6 3.9 15.3 51.4 146.1 30.4 61.3 17.4 5.5 21.8 8.6 9.5 11.8 9.2 21.0 20.3 73.5 121.7 9.7 7.8 35.3 20.0 13.5 10.2 16.2 8.4 9.1 7.8 14.5 5.4 18.7 15.5 9.4 14.4 9.0 17.1 9.9 8.9 4.5 11.0 10.2 5.0 3.1 119.2 85.7 0.0 23.1 12.9 24.9 25.3 4.8 5.8 8.2 17.2 6.6 8.9 11.2 RPGRIP1 "CORD13, LCA6, RGI1, RPGRIP" ENSG00000092200 "RPGR interacting protein 1" Q96KN7 14 21280083-21351301 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Sensory transduction, Vision" "Ciliopathy, Cone-rod dystrophy, Disease variant, Glaucoma, Leber congenital amaurosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 80 "retina: 185.3;testis: 59.6" "Cell type enhanced" "Detected in some" "Cone photoreceptor cells: 231.4;Early spermatids: 177.3;Late spermatids: 108.9;Rod photoreceptor cells: 117.5;Spermatocytes: 51.7" "Cancer enriched" "Detected in single" 5 "testis cancer: 1.0" "Not detected" "Not detected" "Immune cell enhanced" "Detected in some" "neutrophil: 8.8" "Group enriched" "Detected in many" 18 "dendritic cells: 3.3;granulocytes: 8.8;monocytes: 3.7" "Cell line enhanced" "Detected in some" "RT4: 3.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA042955, HPA060190" Supported Supported NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 77: Retina - Visual perception" "Cluster 15: RT4 - Unknown function" "Cluster 9: Photoreceptor cells - Phototransduction" "HPA042955: AB_2678239, HPA060190: AB_2684218" "unprognostic (9.02e-4)" "unprognostic (3.64e-2)" "unprognostic (1.89e-1)" "unprognostic (1.86e-1)" "unprognostic (7.35e-2)" "unprognostic (1.82e-2)" "unprognostic (2.99e-2)" "unprognostic (1.14e-1)" "unprognostic (2.92e-1)" "unprognostic (1.99e-1)" "unprognostic (3.94e-3)" "unprognostic (2.33e-1)" "unprognostic (7.31e-3)" "unprognostic (2.86e-2)" "unprognostic (2.87e-1)" "unprognostic (3.13e-1)" "unprognostic (1.83e-2)" 0.2 0.1 0.5 0.7 0.3 1.2 0.6 0.8 0.6 0.3 0.4 0.5 0.9 0.2 0.0 0.2 0.1 0.3 0.2 0.4 0.3 0.2 0.8 0.5 0.5 0.4 0.2 0.1 0.1 0.2 0.1 1.2 0.6 0.4 0.6 185.3 0.1 0.1 0.1 0.5 0.8 0.0 0.1 1.5 0.2 59.6 0.5 0.1 0.3 0.2 0.3 0.5 0.1 0.3 0.3 0.8 0.8 0.4 0.0 0.0 1.1 0.3 0.0 0.0 0.4 0.5 0.5 1.1 0.2 0.0 0.4 0.2 0.3 0.0 0.0 0.2 0.5 0.4 0.8 0.2 0.0 0.9 0.3 0.4 0.0 0.0 0.0 0.4 0.0 0.8 0.7 0.1 0.0 0.3 0.3 0.5 1.2 0.5 0.3 0.4 0.7 0.9 0.0 3.8 0.6 0.5 0.7 0.8 0.2 0.6 0.3 0.5 0.3 0.2 0.2 0.8 0.6 0.9 0.9 1.0 0.4 0.6 0.2 0.7 3.7 0.0 0.0 1.7 0.1 0.0 0.0 0.0 3.3 0.1 0.1 0.0 8.8 0.3 0.0 0.0 0.0 1.0 0.5 0.3 0.8 0.6 0.4 0.3 0.4 0.2 0.6 0.1 0.5 0.3 0.2 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.2 0.3 1.0 0.0 0.0 0.0 231.4 0.9 0.0 0.0 0.0 0.0 177.3 0.1 0.1 0.6 0.0 0.0 1.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.4 0.9 0.9 0.0 1.2 0.0 0.0 2.7 0.9 108.9 1.8 0.8 0.0 1.0 0.5 4.8 0.0 0.0 0.9 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.7 117.5 0.0 0.1 0.1 51.7 2.2 0.0 0.1 1.5 0.1 0.1 0.0 0.1 RRM2B p53R2 ENSG00000048392 "Ribonucleotide reductase regulatory TP53 inducible subunit M2B" Q7LG56 8 102204502-102238961 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "DNA damage, DNA repair, DNA replication" Oxidoreductase "Disease variant, FDA approved drug targets, Neuropathy, Primary mitochondrial disease, Progressive external ophthalmoplegia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB006854, HPA028812" Approved Enhanced Nucleoplasm,Cytosol NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" "Nucleoplasm, Cytosol" "CAB006854: , HPA028812: AB_10602246" "unprognostic (7.76e-3)" "unprognostic (4.14e-2)" "unprognostic (9.41e-3)" "unprognostic (3.41e-1)" "unprognostic (1.13e-2)" "unprognostic (1.28e-1)" "unprognostic (5.51e-2)" "unprognostic (1.35e-2)" "unprognostic (1.66e-1)" "unprognostic (9.40e-2)" "unprognostic (1.74e-2)" "unprognostic (1.03e-1)" "unprognostic (1.70e-2)" "unprognostic (4.32e-1)" "unprognostic (1.47e-1)" "unprognostic (2.52e-1)" "unprognostic (7.17e-2)" 11.5 21.2 10.5 11.5 12.1 7.1 12.1 13.6 11.5 12.5 26.5 15.3 15.0 11.6 15.1 11.2 13.5 11.9 16.7 10.1 13.7 24.4 22.6 22.0 20.1 13.6 12.4 12.0 13.5 45.0 10.3 13.8 13.9 15.7 15.5 21.9 10.9 13.8 30.4 11.0 10.1 11.7 14.1 14.3 9.5 9.7 12.6 10.1 39.9 34.9 19.6 11.2 5.4 16.8 15.3 26.5 30.7 18.3 43.7 41.3 24.6 34.8 41.4 18.1 21.0 9.6 11.9 97.5 31.8 38.7 18.5 5.7 15.1 35.2 25.3 15.8 16.2 24.4 10.3 20.9 35.3 7.6 50.0 53.1 66.1 20.2 30.5 43.0 51.8 16.3 18.2 14.6 59.1 15.2 13.1 14.6 17.7 16.5 19.2 8.2 12.7 20.1 43.1 17.1 7.8 15.4 17.9 9.7 21.1 76.3 25.5 17.1 39.4 27.8 53.7 19.6 9.6 15.3 15.3 88.0 41.0 11.5 30.2 15.7 6.3 7.0 2.7 5.4 3.8 6.6 2.3 3.2 7.7 8.6 2.6 2.8 23.1 4.1 11.5 2.2 1.8 3.3 10.5 12.1 13.6 11.5 10.1 13.7 13.6 12.4 13.9 14.1 12.6 16.8 16.2 57.7 29.3 10.1 33.5 19.4 8.2 11.8 34.1 13.5 17.0 9.4 22.8 20.0 23.9 40.5 14.6 13.8 13.9 7.3 25.4 6.8 2.3 36.2 11.1 14.9 29.4 3.8 14.6 8.2 5.9 14.8 6.1 11.8 11.4 11.2 18.5 23.6 12.6 10.1 17.6 9.7 10.2 26.2 39.5 1.4 14.3 23.8 17.8 20.6 18.2 24.5 7.2 16.1 12.1 5.7 5.7 14.7 9.3 10.7 8.1 22.7 39.9 18.3 6.6 16.2 16.8 13.2 14.5 26.2 18.5 4.8 12.2 8.6 12.1 6.7 RTN2 "NSP2, NSPL1, SPG12" ENSG00000125744 "Reticulon 2" O75298 19 45485294-45497055 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 8 "skeletal muscle: 509.8;tongue: 207.7" "Group enriched" "Detected in many" 4 "Cytotrophoblasts: 134.3;Extravillous trophoblasts: 145.7;Skeletal myocytes: 73.2;Syncytiotrophoblasts: 120.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 6 "basophil: 6.2;eosinophil: 2.6;plasmacytoid DC: 1.6" "Group enriched" "Detected in many" 10 "dendritic cells: 1.6;granulocytes: 6.2" "Cell line enhanced" "Detected in many" "RH-30: 44.3;RT4: 45.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034941, HPA034948" Approved Approved "Nuclear speckles" NA NA "Cluster 10: Basophils - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 38: Extravillous trophoblasts - Unknown function" "Nuclear speckles" "HPA034941: AB_10671358, HPA034948: AB_2674375" "unprognostic (3.08e-1)" "unprognostic (1.42e-1)" "unprognostic (6.68e-3)" "unprognostic (5.07e-3)" "unprognostic (1.76e-1)" "unprognostic (1.20e-1)" "unprognostic (2.31e-2)" "unprognostic (1.89e-2)" "unprognostic (3.09e-1)" "unprognostic (6.44e-2)" "unprognostic (5.10e-3)" "unprognostic (2.96e-2)" "prognostic unfavorable (5.58e-6)" "unprognostic (4.34e-1)" "unprognostic (3.23e-1)" "unprognostic (2.21e-1)" "unprognostic (2.03e-1)" 9.9 13.6 21.4 3.4 25.7 1.7 12.0 15.9 43.6 5.9 7.8 21.8 2.8 15.2 2.5 12.1 4.6 7.9 21.9 24.7 22.0 7.1 3.9 8.2 4.7 27.3 19.3 1.9 4.8 10.1 7.6 19.2 27.0 17.0 2.2 5.7 22.3 10.6 509.8 9.1 8.7 7.3 14.1 11.2 7.9 1.6 25.1 1.1 4.9 207.7 2.0 12.4 7.8 29.0 3.8 5.2 8.6 6.7 14.4 17.6 16.9 8.5 20.0 5.2 9.9 10.4 3.2 3.3 11.4 9.3 4.2 7.2 5.6 4.1 1.7 7.9 8.2 23.0 3.9 7.8 6.2 1.4 25.0 19.5 2.2 2.3 4.2 9.2 9.6 0.9 12.9 6.2 15.6 2.9 0.0 4.3 6.3 17.0 6.8 3.6 44.3 18.8 3.0 45.0 24.1 23.1 1.7 40.7 13.2 8.0 32.3 9.1 8.6 14.7 4.4 0.4 1.9 3.5 8.7 7.7 3.9 5.2 7.7 6.2 0.1 2.6 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.6 0.2 0.3 1.6 0.0 0.2 21.4 25.7 15.9 43.6 24.7 22.0 27.3 19.3 27.0 14.1 25.1 29.0 9.8 3.2 8.1 2.6 0.8 6.4 27.7 8.9 6.8 10.4 18.4 21.1 4.6 4.3 4.6 3.7 6.2 134.3 2.9 0.9 0.0 21.3 0.3 2.1 7.0 15.3 11.4 1.7 21.0 6.8 145.7 14.0 3.1 3.4 16.5 4.2 18.9 3.1 27.3 23.5 13.3 2.2 12.2 12.9 12.0 0.4 5.6 10.7 23.2 1.9 6.5 9.1 1.0 4.5 2.1 13.1 0.3 6.8 2.5 13.0 0.3 0.3 1.3 13.6 13.1 73.2 12.3 0.5 3.9 2.3 3.4 120.1 1.0 16.4 0.7 23.2 RTN4IP1 NIMP ENSG00000130347 "Reticulon 4 interacting protein 1" Q8WWV3 6 106570771-106629498 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Neurogenesis "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal tubular cells: 27.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036357 Approved NA NA "Cluster 15: NK-cells - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" "HPA036357: AB_10673128" "prognostic unfavorable (9.18e-6)" "unprognostic (5.87e-2)" "unprognostic (2.20e-3)" "unprognostic (2.88e-1)" "unprognostic (3.51e-2)" "unprognostic (3.71e-2)" "unprognostic (7.37e-3)" "unprognostic (1.57e-1)" "unprognostic (7.77e-2)" "unprognostic (3.35e-1)" "unprognostic (2.51e-2)" "unprognostic (1.72e-2)" "prognostic favorable (8.55e-6)" "unprognostic (1.62e-1)" "unprognostic (9.82e-2)" "unprognostic (3.71e-1)" "unprognostic (5.76e-2)" 2.5 6.8 2.8 3.1 3.0 1.8 3.2 3.3 3.9 2.6 3.3 6.3 4.8 2.7 5.5 4.2 2.7 1.6 14.7 2.7 2.7 6.4 7.4 2.0 4.6 2.5 2.5 2.2 3.2 5.2 4.5 2.2 2.8 2.7 6.0 6.0 4.6 2.7 15.6 2.9 4.5 2.9 2.5 4.2 5.9 5.5 2.8 3.0 4.0 15.4 6.1 2.9 2.8 3.4 7.6 10.8 7.3 12.6 5.9 3.5 8.6 5.0 7.0 7.7 7.4 17.4 4.1 11.6 7.6 6.5 15.1 10.8 13.0 10.7 12.1 8.1 7.4 12.1 8.4 14.0 6.1 12.5 8.1 5.2 8.3 10.3 6.7 4.7 6.9 16.3 21.7 4.7 8.5 11.3 4.7 14.4 9.1 10.7 7.9 16.1 13.3 8.8 12.4 8.1 7.1 5.7 4.7 12.3 11.2 7.5 15.5 8.0 3.6 4.4 6.1 8.8 8.9 3.5 5.7 24.8 11.5 18.1 9.6 0.1 4.6 2.2 3.2 5.1 3.3 11.4 4.4 3.4 10.7 16.0 4.0 3.9 0.8 6.5 3.7 5.6 8.2 3.3 2.8 3.0 3.3 3.9 2.7 2.7 2.5 2.5 2.8 2.5 2.8 3.4 1.6 0.0 2.8 7.8 8.1 0.8 1.9 6.4 0.6 5.5 2.8 1.7 18.4 4.3 3.1 1.8 8.4 12.5 1.3 5.2 27.4 6.7 8.5 7.6 2.0 2.1 4.2 1.3 15.6 8.6 15.0 2.1 4.1 4.2 2.5 3.6 2.5 5.5 7.3 0.0 17.2 3.0 10.2 5.4 1.8 3.4 0.6 3.6 0.0 8.4 0.9 3.7 1.0 6.6 17.5 4.9 3.0 1.9 4.2 1.2 3.3 14.5 5.4 6.2 13.1 2.1 2.5 11.9 16.7 4.1 1.0 5.6 2.8 5.6 6.4 2.0 RUBCN "KIAA0226, rubicon, rundataxin" ENSG00000145016 "Rubicon autophagy regulator" Q92622 3 197668867-197749727 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Autophagy, Endocytosis, Immunity, Phagocytosis" Neurodegeneration "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "monocytes: 67.5;Plasma cells: 48.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Karpas-707: 87.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA050908, HPA054497" Approved Supported Vesicles,Cytosol NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" "Vesicles, Cytosol" "HPA050908: , HPA054497: AB_2682507" "unprognostic (2.91e-2)" "unprognostic (1.61e-2)" "prognostic unfavorable (6.65e-4)" "unprognostic (1.34e-3)" "unprognostic (1.46e-1)" "unprognostic (1.20e-2)" "prognostic unfavorable (9.91e-5)" "unprognostic (1.99e-1)" "unprognostic (6.71e-2)" "unprognostic (2.86e-2)" "unprognostic (1.71e-1)" "prognostic unfavorable (1.62e-4)" "unprognostic (2.22e-2)" "unprognostic (2.92e-2)" "unprognostic (1.75e-1)" "unprognostic (2.43e-1)" "unprognostic (1.23e-1)" 8.3 7.5 16.2 11.6 16.3 8.5 7.2 10.5 17.0 9.2 4.4 10.4 7.3 8.8 4.0 12.0 8.5 7.2 11.4 17.0 19.0 7.7 5.6 11.8 15.3 20.0 17.8 10.7 9.1 6.8 15.8 5.8 15.9 7.4 5.7 10.9 7.3 7.2 8.9 9.1 13.1 7.8 14.5 19.2 8.1 14.6 23.7 8.8 7.1 8.1 16.1 8.9 8.4 17.4 30.9 7.4 8.2 16.2 14.4 8.3 8.6 13.8 9.2 17.0 14.2 12.7 8.4 33.6 26.7 15.8 16.1 17.0 15.0 8.0 13.6 9.3 13.9 21.6 13.4 4.9 8.4 12.0 18.0 7.0 9.6 14.8 17.6 7.9 10.7 14.4 12.3 87.7 11.5 24.4 15.7 7.5 7.1 8.8 23.2 14.9 8.6 22.6 9.6 13.9 34.3 7.9 10.2 19.8 10.8 5.5 29.2 8.1 13.7 9.9 9.9 27.8 18.9 36.5 34.2 27.0 13.6 22.4 8.7 0.8 2.6 17.5 3.7 3.9 2.4 7.7 3.1 4.7 1.6 8.5 2.2 3.2 2.9 1.8 4.8 16.6 4.4 1.7 16.2 16.3 10.5 17.0 17.0 19.0 20.0 17.8 15.9 14.5 23.7 17.4 8.5 6.4 11.2 0.0 33.9 0.0 6.0 0.0 8.0 21.0 7.3 7.0 0.0 7.2 4.3 12.9 18.8 1.8 28.9 3.8 1.9 5.8 21.7 4.8 6.2 6.7 0.0 5.7 0.0 6.4 3.7 4.8 7.1 9.8 2.5 6.1 9.3 3.5 9.2 21.9 0.0 3.7 0.0 16.3 0.0 16.4 5.0 18.7 0.0 0.0 67.5 15.0 14.4 0.0 0.0 8.5 1.5 6.4 48.3 8.9 5.8 2.7 0.7 14.3 6.6 9.7 6.8 34.1 21.3 5.6 0.0 6.4 15.9 4.9 2.8 12.3 S1PR2 "AGR16, DFNB68, EDG5, Gpcr13, H218" ENSG00000267534 "Sphingosine-1-phosphate receptor 2" O95136 19 10221433-10231331 "Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins" "G-protein coupled receptor, Receptor, Transducer" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in many" 4 "Cytotrophoblasts: 92.9;Early spermatids: 92.3;Late spermatids: 184.9;Syncytiotrophoblasts: 68.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 45.0" "Group enriched" "Detected in many" 8 "granulocytes: 45.0;T-cells: 12.4" "Cell line enhanced" "Detected in many" "BEWO: 29.4;Daudi: 54.1;U-266/70: 38.9;U-698: 57.3;WM-115: 38.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA014255, HPA014307" Approved Uncertain "Nuclear speckles,Golgi apparatus" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 28: Placenta - Pregnancy" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 47: Cytotrophoblasts - Unknown function" "Golgi apparatus" "Nuclear speckles" "HPA014255: , HPA014307: AB_1847989" "unprognostic (5.38e-3)" "unprognostic (1.83e-3)" "unprognostic (1.20e-1)" "unprognostic (1.26e-2)" "unprognostic (3.31e-2)" "unprognostic (1.05e-3)" "unprognostic (8.50e-2)" "unprognostic (8.71e-2)" "unprognostic (2.84e-1)" "unprognostic (1.70e-1)" "unprognostic (7.40e-3)" "unprognostic (1.47e-2)" "prognostic unfavorable (4.36e-10)" "unprognostic (4.91e-2)" "unprognostic (4.56e-2)" "unprognostic (3.11e-1)" "unprognostic (8.09e-2)" 7.7 2.5 1.9 6.4 1.8 1.2 5.5 1.7 1.8 10.4 1.9 4.8 1.8 8.3 2.7 3.3 8.4 6.2 6.6 1.6 2.0 3.1 5.6 13.7 10.9 2.8 1.9 5.6 2.9 2.5 3.0 18.5 2.2 6.9 2.4 1.2 4.1 2.3 0.8 5.4 4.8 4.2 2.0 1.9 4.3 13.2 2.1 1.4 3.4 1.3 10.9 8.3 7.0 2.9 3.0 0.4 3.4 6.9 18.2 22.2 29.4 4.4 8.9 1.9 4.1 1.9 1.7 54.1 5.1 8.2 2.3 1.7 1.2 2.1 1.3 5.5 2.7 1.2 1.2 1.3 6.1 1.4 1.1 12.2 1.1 3.8 1.3 5.3 0.2 2.6 1.3 11.1 1.3 2.5 0.6 2.5 3.4 0.9 1.7 3.8 1.4 2.0 1.6 2.5 2.4 4.7 2.5 1.5 3.8 2.6 1.2 1.3 0.4 6.9 2.2 15.9 1.3 38.9 19.6 57.3 2.6 2.7 38.6 45.0 2.8 0.6 7.2 2.4 8.9 0.3 9.2 7.0 2.6 0.5 3.7 3.8 0.7 3.6 1.0 0.4 12.4 2.0 1.9 1.8 1.7 1.8 1.6 2.0 2.8 1.9 2.2 2.0 2.1 2.9 2.0 0.0 1.1 0.3 2.0 0.0 4.6 0.0 1.2 0.6 8.3 4.6 0.6 2.8 0.6 1.8 2.1 92.9 5.4 0.0 0.0 3.6 92.3 8.6 21.5 2.0 2.4 0.0 0.3 3.3 18.1 17.7 0.0 18.1 0.0 2.0 3.9 7.6 13.2 0.0 0.9 0.5 0.0 3.1 0.0 184.9 22.1 7.2 0.0 0.0 4.0 7.1 3.1 6.6 0.5 2.7 0.3 13.2 2.6 4.9 0.0 0.9 0.0 0.5 13.1 2.0 4.6 1.5 1.2 2.0 0.0 68.4 4.2 1.1 0.2 4.1 SACS "ARSACS, DKFZp686B15167, DNAJC29, KIAA0730, PPP1R138, SPAX6" ENSG00000151835 "Sacsin molecular chaperone" Q9NZJ4 13 23328826-23433740 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" Chaperone "Cancer-related genes, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 70.5;Excitatory neurons: 86.3;Inhibitory neurons: 108.2;Oligodendrocyte precursor cells: 76.4;Oligodendrocytes: 111.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB017714 Uncertain NA NA "Cluster 24: B-cells - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB017714: " "unprognostic (1.22e-1)" "unprognostic (2.18e-1)" "unprognostic (2.02e-3)" "prognostic unfavorable (9.04e-4)" "unprognostic (1.26e-2)" "unprognostic (1.66e-1)" "unprognostic (2.05e-3)" "unprognostic (2.59e-2)" "unprognostic (2.49e-1)" "unprognostic (4.14e-2)" "unprognostic (5.05e-1)" "unprognostic (2.04e-1)" "prognostic unfavorable (6.21e-6)" "unprognostic (2.84e-1)" "unprognostic (4.06e-2)" "unprognostic (3.67e-2)" "unprognostic (7.65e-4)" 4.8 4.4 4.7 4.0 10.0 5.6 4.3 7.2 16.1 4.8 0.0 8.0 0.9 6.2 2.7 3.7 5.8 2.2 8.7 7.6 3.0 3.2 2.2 4.8 4.3 8.4 5.2 4.7 4.8 15.2 6.8 1.3 9.4 7.6 1.5 4.6 6.6 2.3 14.0 2.4 5.0 4.9 2.0 8.5 5.1 6.8 10.3 4.2 2.6 13.1 3.6 9.9 4.4 11.4 8.1 10.5 21.3 6.5 6.5 24.3 3.1 18.1 23.2 6.9 5.7 5.0 4.2 5.5 7.4 38.8 9.0 1.6 30.7 10.8 22.5 12.9 12.6 20.7 8.1 7.4 4.8 38.1 7.9 7.8 2.5 44.3 21.2 9.7 23.1 17.0 12.1 2.6 31.6 3.8 13.6 14.6 17.5 2.8 8.2 16.0 38.7 16.7 12.0 0.9 15.4 14.8 10.0 3.6 7.8 9.7 1.9 10.0 49.8 21.1 17.4 11.5 34.6 5.0 5.7 13.3 10.1 13.2 18.7 0.0 0.1 0.2 0.2 0.2 0.4 0.2 0.3 0.2 0.4 0.7 0.2 0.3 0.0 0.3 0.0 0.3 0.7 0.1 4.7 10.0 7.2 16.1 7.6 3.0 8.4 5.2 9.4 2.0 10.3 11.4 10.3 0.0 1.3 70.5 14.5 6.1 5.4 2.0 6.8 16.5 8.2 8.0 21.3 1.5 1.4 1.8 0.0 0.4 15.3 0.2 0.0 9.0 13.1 5.6 28.1 11.6 1.2 9.7 86.3 10.4 1.5 17.4 3.1 3.3 2.5 18.8 3.6 0.7 3.4 25.2 108.2 0.4 2.0 4.9 19.4 11.6 4.1 8.1 8.8 19.7 3.9 13.6 6.2 76.4 111.0 16.7 0.2 5.3 12.9 8.1 0.0 1.3 1.2 5.3 13.1 45.6 20.9 20.5 9.5 5.3 5.1 0.0 18.1 20.0 0.8 2.9 SAG "ARRESTIN, RP47" ENSG00000130561 "S-antigen visual arrestin" P10523 2 233307816-233347055 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Congenital stationary night blindness, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 474 "retina: 1466.0" "Cell type enriched" "Detected in some" 5 "Rod photoreceptor cells: 6946.1" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA004946 Enhanced NA NA "Cluster 79: Retina - Phototransduction" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA004946: AB_2667304" "unprognostic (4.76e-2)" "unprognostic (1.94e-2)" "unprognostic (4.52e-3)" "unprognostic (3.95e-1)" "unprognostic (8.54e-2)" "unprognostic (2.89e-2)" "unprognostic (3.86e-2)" "unprognostic (2.26e-2)" "unprognostic (1.78e-1)" "unprognostic (4.54e-1)" "unprognostic (4.57e-2)" "unprognostic (3.02e-1)" "unprognostic (1.12e-9)" "unprognostic (2.56e-1)" "unprognostic (1.61e-1)" "unprognostic (2.85e-1)" "unprognostic (1.03e-5)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1466.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.3 1.6 0.2 0.0 651.7 0.2 0.3 1.0 0.0 0.0 0.0 869.5 1.5 0.7 0.6 0.0 0.0 40.4 0.9 0.2 41.6 0.0 0.0 0.4 0.0 0.1 0.4 0.0 0.4 0.0 0.0 0.0 0.0 0.1 338.2 0.5 0.0 0.0 1.5 2.3 121.5 0.9 0.5 0.0 0.0 0.7 1191.9 0.0 0.5 0.2 0.0 0.0 0.0 0.4 1.2 0.9 0.0 0.2 6946.1 13.1 1.7 0.4 2.1 1.6 0.0 0.6 0.4 0.9 0.1 0.2 1.2 SAMD12 FLJ39458 ENSG00000177570 "Sterile alpha motif domain containing 12" Q8N8I0 8 118189455-118622112 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Epilepsy "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in many" 4 "Excitatory neurons: 537.6;Inhibitory neurons: 531.7;Oligodendrocytes: 1158.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "SK-BR-3: 34.6;U-266/70: 14.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024634 Uncertain Approved "Golgi apparatus,Cytosol" NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 27: Brain & Skin - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Golgi apparatus, Cytosol" "HPA024634: AB_1856549" "unprognostic (6.96e-2)" "unprognostic (9.35e-2)" "unprognostic (1.95e-1)" "prognostic unfavorable (1.11e-4)" "unprognostic (4.03e-1)" "unprognostic (1.16e-1)" "unprognostic (2.12e-2)" "unprognostic (2.92e-2)" "unprognostic (2.99e-2)" "unprognostic (1.68e-1)" "unprognostic (3.94e-3)" "unprognostic (2.01e-1)" "prognostic favorable (1.52e-6)" "unprognostic (3.31e-2)" "unprognostic (1.76e-1)" "unprognostic (1.94e-1)" "unprognostic (6.35e-3)" 0.7 1.4 2.4 1.1 4.9 0.4 3.0 0.7 8.8 2.3 0.0 4.0 3.7 1.1 4.0 4.1 5.3 3.6 6.9 7.5 0.8 5.2 1.6 4.2 0.7 1.4 0.5 0.9 1.9 9.6 3.3 0.1 2.6 3.7 4.7 5.9 2.4 5.0 0.8 0.8 2.0 0.7 0.9 2.6 5.7 1.3 2.1 1.0 10.2 0.1 2.0 4.4 1.1 8.4 10.2 0.7 0.9 0.0 0.0 0.0 2.1 3.4 10.4 7.8 4.3 1.1 12.1 3.4 0.8 8.2 1.6 1.9 2.0 4.7 11.9 0.1 1.1 0.0 5.7 0.0 0.0 0.0 0.2 0.0 2.3 4.6 0.4 2.8 0.2 5.9 0.0 6.0 6.0 2.0 1.6 0.0 0.8 13.2 1.3 0.0 0.0 9.7 5.4 13.5 4.0 0.0 2.8 34.6 0.0 2.1 0.5 0.0 0.0 0.1 3.8 1.4 1.2 14.9 10.2 0.4 1.8 0.0 1.1 0.1 0.0 0.0 0.1 0.0 1.0 1.5 0.8 0.5 0.0 1.0 1.0 0.6 0.1 0.6 0.0 0.3 0.8 0.2 2.4 4.9 0.7 8.8 7.5 0.8 1.4 0.5 2.6 0.9 2.1 8.4 4.7 112.2 95.0 53.5 8.0 1.7 10.1 10.3 13.1 16.8 10.9 5.1 12.1 12.8 57.5 29.5 43.8 0.0 3.3 10.5 19.6 12.9 5.2 12.1 1.5 13.0 14.3 2.1 537.6 12.4 0.1 9.1 26.5 16.4 56.8 4.4 7.5 5.2 0.1 30.3 531.7 11.2 14.2 0.3 0.0 6.1 0.3 6.5 7.2 163.0 0.7 4.5 4.1 122.6 1158.0 13.0 3.5 0.4 16.9 5.0 8.6 17.4 68.0 26.9 0.0 0.5 0.9 0.5 2.4 15.9 1.7 0.0 8.9 4.5 11.9 13.6 SBF1 "DENND7A, MTMR5" ENSG00000100241 "SET binding factor 1" O95248 22 50445000-50475035 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Guanine-nucleotide releasing factor" "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA074004 Supported "Nuclear bodies" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 78: Testis - Spermatogenesis" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 59: Non-specific - Transcription" "Nuclear bodies" "HPA074004: AB_2732249" "unprognostic (4.79e-2)" "unprognostic (1.37e-1)" "unprognostic (7.39e-2)" "unprognostic (4.87e-2)" "unprognostic (6.11e-2)" "prognostic favorable (3.46e-5)" "unprognostic (2.21e-3)" "unprognostic (1.14e-1)" "unprognostic (2.32e-2)" "unprognostic (3.60e-3)" "unprognostic (1.78e-1)" "unprognostic (1.75e-2)" "unprognostic (2.42e-2)" "unprognostic (3.29e-2)" "unprognostic (1.12e-1)" "unprognostic (1.74e-2)" "unprognostic (2.05e-1)" 26.8 32.3 50.8 22.3 57.3 20.6 24.2 31.8 72.4 25.9 9.2 32.9 14.8 29.5 3.2 43.9 27.2 10.6 38.7 70.1 28.5 30.5 23.4 26.8 28.8 52.0 39.2 30.4 48.0 7.1 28.6 8.8 46.5 28.5 4.9 6.5 26.9 11.6 75.7 42.2 38.6 8.8 32.8 35.4 30.1 111.2 44.1 32.7 62.3 14.4 14.7 28.3 27.3 63.5 34.3 28.2 24.0 32.9 24.3 18.6 65.9 23.5 20.1 21.6 17.7 39.0 23.7 78.1 16.7 27.9 23.9 31.4 19.9 28.7 5.3 28.6 76.0 17.6 59.6 50.7 41.7 54.7 26.1 25.0 44.6 28.1 21.0 17.0 14.8 41.6 28.8 20.8 15.0 42.6 54.8 52.4 10.1 26.1 31.7 71.0 45.6 48.3 12.8 27.3 19.1 46.0 36.5 35.5 47.7 10.5 20.7 25.2 25.1 33.9 49.6 24.3 29.7 38.1 13.4 37.6 38.8 22.1 32.7 0.5 1.3 2.1 4.4 1.3 2.4 2.6 3.0 3.5 1.6 1.6 2.2 3.6 1.9 1.9 2.6 5.6 2.6 2.3 50.8 57.3 31.8 72.4 70.1 28.5 52.0 39.2 46.5 32.8 44.1 63.5 5.7 6.4 11.8 10.7 13.7 13.4 4.6 9.3 6.8 15.5 11.3 9.1 7.6 4.3 9.4 3.7 10.4 4.9 21.4 19.9 1.9 7.2 32.8 10.3 8.9 5.6 3.6 8.6 11.3 12.5 7.9 10.6 24.5 11.4 1.3 20.4 5.7 9.1 6.9 11.8 10.9 13.2 10.2 6.9 10.7 21.4 6.5 9.5 5.4 5.6 10.8 6.9 21.6 11.1 31.7 19.9 8.1 6.0 15.6 11.6 16.0 7.7 11.1 10.0 6.6 12.3 11.6 25.5 23.5 21.3 14.6 11.5 19.8 12.2 12.3 10.1 SBF2 "CMT4B2, DENND7B, KIAA1766, MTMR13" ENSG00000133812 "SET binding factor 2" Q86WG5 11 9778667-10294219 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Autophagy "Guanine-nucleotide releasing factor" "Charcot-Marie-Tooth disease, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 224.6;Excitatory neurons: 244.9;Inhibitory neurons: 367.4;Microglial cells: 273.6;Oligodendrocyte precursor cells: 290.5;Oligodendrocytes: 228.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "non-classical monocyte: 1.6" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "BEWO: 105.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA050933 Uncertain Approved "Nucleoplasm,Intermediate filaments,Cytosol" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 28: BEWO - Transcription regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "Intermediate filaments, Cytosol" "HPA050933: AB_2681280" "unprognostic (2.26e-1)" "unprognostic (1.45e-2)" "unprognostic (1.91e-2)" "unprognostic (1.00e-1)" "unprognostic (2.28e-1)" "unprognostic (5.36e-2)" "unprognostic (5.55e-2)" "unprognostic (6.44e-3)" "unprognostic (2.84e-2)" "unprognostic (1.87e-1)" "unprognostic (3.62e-3)" "unprognostic (2.43e-1)" "prognostic favorable (3.66e-5)" "unprognostic (3.72e-2)" "unprognostic (8.77e-2)" "unprognostic (3.43e-1)" "unprognostic (4.11e-2)" 13.3 7.6 8.6 6.2 9.2 4.0 9.2 6.4 7.7 15.2 5.1 9.3 6.8 11.3 9.1 11.6 10.2 10.4 8.9 6.7 7.7 13.8 9.5 7.4 3.9 6.9 8.1 18.0 5.1 17.1 4.6 14.2 7.2 10.6 10.5 14.9 9.3 11.4 4.7 7.4 6.6 10.9 7.1 7.8 9.5 10.8 7.1 6.1 16.7 8.9 4.2 11.2 8.2 8.2 15.1 12.1 20.8 15.0 27.1 35.4 105.4 11.6 20.9 13.1 18.2 9.1 18.1 5.8 6.2 20.6 19.1 9.8 12.5 9.8 22.9 6.2 8.6 2.5 9.1 11.9 10.6 5.6 8.0 17.5 12.3 6.6 25.8 20.2 21.8 12.1 5.1 5.2 15.8 4.3 8.1 1.5 9.1 13.5 13.3 7.5 14.5 7.6 11.9 13.4 6.9 15.4 15.7 22.4 10.0 10.6 6.7 4.0 24.4 23.1 11.5 24.3 9.5 1.7 4.6 8.0 17.4 2.7 17.0 0.0 0.7 0.0 0.0 0.6 0.2 0.0 0.0 0.1 0.3 0.2 0.1 0.0 1.1 0.3 1.6 0.1 0.1 0.2 8.6 9.2 6.4 7.7 6.7 7.7 6.9 8.1 7.2 7.1 7.1 8.2 50.2 44.8 83.9 224.6 16.4 25.5 43.4 24.1 27.3 35.1 16.4 14.5 31.4 22.8 30.8 16.5 75.0 13.8 14.6 20.3 3.9 13.9 18.3 17.8 31.1 40.9 43.8 11.4 244.9 8.8 12.9 40.0 40.8 30.1 21.5 41.7 49.6 16.6 18.6 37.0 367.4 16.2 24.4 55.0 34.1 9.2 51.0 44.8 30.2 273.6 37.6 12.0 29.9 290.5 228.4 13.5 21.2 27.1 9.5 56.5 14.5 13.1 38.3 71.6 26.3 44.0 34.8 24.5 17.4 30.6 30.7 13.8 20.6 25.9 20.1 47.4 SCARB2 "CD36L2, HLGP85, LIMP-2, LIMPII, SR-BII" ENSG00000138760 "Scavenger receptor class B member 2" Q14108 4 76158737-76234536 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Host-virus interaction" "Host cell receptor for virus entry, Receptor" "Disease variant, Epilepsy, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 4 "basophil: 12.5;classical monocyte: 14.1;intermediate monocyte: 26.0;myeloid DC: 8.2;non-classical monocyte: 24.9;plasmacytoid DC: 28.9" "Group enriched" "Detected in all" 5 "dendritic cells: 28.9;granulocytes: 12.5;monocytes: 26.0" "Cell line enhanced" "Detected in many" "ASC diff: 499.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB015415, HPA018014" Supported Approved Cytosol NA NA 9200 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 15: Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 35: Glandular cells - Unknown function" Cytosol "CAB015415: AB_831511, HPA018014: AB_1852881" "prognostic unfavorable (2.82e-5)" "unprognostic (2.73e-2)" "unprognostic (4.09e-2)" "unprognostic (4.96e-2)" "unprognostic (4.17e-3)" "unprognostic (1.12e-3)" "unprognostic (2.08e-1)" "unprognostic (5.48e-2)" "unprognostic (4.06e-1)" "unprognostic (1.25e-2)" "unprognostic (4.11e-2)" "unprognostic (1.67e-1)" "unprognostic (1.91e-2)" "unprognostic (1.17e-1)" "unprognostic (6.88e-2)" "unprognostic (5.06e-2)" "unprognostic (3.89e-2)" 60.6 24.0 33.5 27.7 63.5 7.3 56.7 58.9 38.9 60.8 18.9 61.6 39.2 44.1 58.4 33.9 45.4 60.0 61.6 29.6 48.6 46.8 89.9 77.1 20.2 62.2 49.6 58.9 58.9 63.6 11.1 80.2 62.5 72.3 64.0 53.2 80.5 55.4 89.8 26.0 49.1 57.8 60.1 47.0 60.7 19.4 50.7 21.3 65.9 81.3 20.6 65.3 25.1 92.9 39.8 38.4 48.9 97.1 499.7 242.0 35.8 131.5 250.2 114.0 178.2 72.5 112.3 0.0 85.1 262.3 109.6 28.3 28.3 78.9 96.0 138.8 30.1 3.2 32.9 25.3 129.9 19.0 12.1 186.9 72.3 117.3 54.5 268.9 200.6 10.0 15.6 188.6 159.2 58.2 1.6 4.0 9.7 120.3 23.6 23.3 82.7 42.0 64.4 43.6 101.3 110.2 104.7 61.3 115.5 49.3 34.6 17.1 131.3 125.9 48.5 104.7 47.5 167.6 98.8 0.2 158.1 22.2 170.9 12.5 14.1 3.1 2.8 26.0 2.6 3.8 1.9 1.5 8.2 3.0 2.6 4.3 1.9 1.1 24.9 28.9 3.0 6.1 33.5 63.5 58.9 38.9 29.6 48.6 62.2 49.6 62.5 60.1 50.7 92.9 89.0 176.3 52.4 47.3 20.1 24.0 90.5 64.8 34.1 109.6 69.7 36.4 53.0 87.2 52.1 99.3 60.5 35.3 43.6 109.0 7.9 119.9 7.1 50.3 74.0 69.9 102.4 28.6 57.4 72.9 47.5 108.3 40.8 88.8 3.8 84.8 79.6 108.7 143.4 60.6 55.4 77.1 44.7 165.7 27.5 5.6 45.4 76.2 67.6 38.4 43.5 87.2 6.2 106.1 201.1 78.0 68.3 66.5 82.2 133.5 103.2 27.6 54.4 81.7 92.1 91.0 68.1 18.2 16.5 34.8 33.8 59.4 16.3 56.5 55.3 93.4 SCN11A "NaN, Nav1.9, SCN12A, SNS-2" ENSG00000168356 "Sodium voltage-gated channel alpha subunit 11" Q9UI33 3 38845764-39052157 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Sodium transport, Transport" "Ion channel, Sodium channel, Voltage-gated channel" "Disease variant, FDA approved drug targets, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "lymphoid tissue: 3.0;placenta: 1.9" "Cell type enhanced" "Detected in some" "Adipocytes: 5.4;Astrocytes: 7.8;Early spermatids: 7.0;Sertoli cells: 6.6;Spermatocytes: 4.4;Spermatogonia: 6.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "HDLM-2: 1.0" "Not detected" "Not detected" "Not detected" "Not detected" "HPA036746, HPA036747" Uncertain NA NA "Cluster 64: Macrophages - Immune response" "Cluster 44: HDLM-2 - Immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "HPA036746: AB_10696785, HPA036747: AB_2675287" "unprognostic (6.11e-2)" "unprognostic (5.16e-1)" "unprognostic (1.66e-1)" "unprognostic (4.75e-2)" "unprognostic (4.21e-2)" "unprognostic (2.34e-2)" "unprognostic (2.79e-2)" "unprognostic (5.66e-2)" "unprognostic (4.44e-2)" "unprognostic (5.21e-2)" "unprognostic (2.30e-4)" "unprognostic (1.91e-2)" "unprognostic (5.43e-2)" "unprognostic (5.02e-2)" "unprognostic (2.95e-1)" "unprognostic (3.12e-2)" "unprognostic (8.30e-4)" 0.5 0.1 0.4 0.2 0.2 0.0 0.3 0.2 0.3 0.1 0.1 0.6 0.3 0.0 0.4 0.0 0.1 0.1 0.0 0.4 0.3 0.5 0.2 0.1 0.2 0.3 0.4 0.1 0.1 0.0 0.3 1.9 0.3 0.1 0.6 0.1 0.0 0.1 0.1 0.4 0.5 0.3 0.3 3.0 0.1 1.3 0.5 0.2 0.1 0.0 0.1 0.8 0.2 0.4 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.2 0.3 0.4 0.3 0.3 0.4 0.3 0.3 0.5 0.4 5.4 0.0 0.0 7.8 0.1 0.8 0.9 0.0 0.0 0.2 0.2 0.3 1.2 0.0 0.6 0.0 0.0 0.2 0.0 0.0 0.0 0.1 7.0 0.4 0.5 2.5 0.0 2.7 1.6 0.2 0.1 0.6 0.0 0.2 0.0 1.1 1.4 0.4 0.3 0.0 1.0 0.0 0.0 0.3 1.6 2.1 0.0 0.2 1.8 0.0 0.1 0.5 0.0 1.5 2.4 0.1 0.0 0.0 0.1 0.7 0.0 0.2 2.3 0.5 6.6 1.0 0.4 4.4 6.3 0.0 0.9 0.3 0.6 0.7 0.0 0.8 SCN1A "FEB3, GEFSP2, HBSCI, NAC1, Nav1.1, SCN1, SMEI" ENSG00000144285 "Sodium voltage-gated channel alpha subunit 1" P35498 2 165984641-166149214 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Sodium transport, Transport" "Ion channel, Sodium channel, Voltage-gated channel" "Autism, Autism spectrum disorder, Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "brain: 24.7" "Group enriched" "Detected in some" 11 "Excitatory neurons: 409.9;Inhibitory neurons: 494.6;Oligodendrocyte precursor cells: 692.1" "Cancer enriched" "Detected in single" 8 "glioma: 1.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "ASC TERT1: 6.1;Hep G2: 3.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA078664 Supported "Nucleoplasm,Nuclear bodies,Plasma membrane" NA NA "Cluster 65: Brain - Ion transport" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Plasma membrane" "Nuclear bodies" "HPA078664: AB_2686888" "unprognostic (9.25e-2)" "unprognostic (3.97e-2)" "unprognostic (6.88e-2)" "unprognostic (7.44e-2)" "unprognostic (1.50e-1)" "unprognostic (2.74e-1)" "unprognostic (4.70e-2)" "unprognostic (2.88e-1)" "unprognostic (1.67e-1)" "unprognostic (9.59e-2)" "unprognostic (1.23e-1)" "unprognostic (5.03e-9)" "unprognostic (6.92e-2)" "unprognostic (3.69e-2)" "unprognostic (5.06e-3)" "unprognostic (6.93e-1)" 0.0 0.0 4.2 0.0 4.2 0.0 0.0 2.1 24.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.1 2.1 6.9 0.0 0.0 1.4 0.0 14.2 6.2 0.0 0.0 0.0 2.0 0.0 18.5 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.1 10.9 0.0 0.0 0.0 0.0 0.0 0.0 10.9 0.0 0.0 0.9 0.0 0.0 6.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 3.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.2 4.2 2.1 24.7 2.1 6.9 14.2 6.2 18.5 2.2 10.9 10.9 0.0 6.4 33.9 27.4 0.0 0.0 0.0 0.0 0.0 47.4 0.6 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 4.5 0.0 0.3 1.8 0.0 409.9 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.3 0.0 494.6 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 18.7 0.0 2.8 0.0 692.1 11.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.1 0.0 0.0 0.1 0.1 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 SCN1B ENSG00000105711 "Sodium voltage-gated channel beta subunit 1" Q07699 19 35030470-35040449 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Cell adhesion, Ion transport, Sodium transport, Transport" "Ion channel, Sodium channel, Voltage-gated channel" "Atrial fibrillation, Brugada syndrome, Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 256.5;skeletal muscle: 572.0;tongue: 227.8" "Cell type enhanced" "Detected in many" "Bipolar cells: 67.9;Excitatory neurons: 50.4;Hofbauer cells: 31.3;Inhibitory neurons: 48.3;Kupffer cells: 35.1;Macrophages: 29.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 17.5;EFO-21: 12.7;TIME: 26.1" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebral cortex: 349.1" "Secreted in other tissues" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 51: Myeloid cells - Hemostasis" "unprognostic (8.18e-2)" "unprognostic (1.30e-1)" "unprognostic (1.30e-2)" "unprognostic (6.40e-2)" "unprognostic (1.17e-2)" "unprognostic (2.69e-2)" "unprognostic (4.40e-2)" "unprognostic (1.20e-1)" "unprognostic (3.34e-2)" "unprognostic (4.72e-3)" "prognostic favorable (1.38e-4)" "unprognostic (2.25e-1)" "unprognostic (2.05e-2)" "unprognostic (9.68e-3)" "unprognostic (5.81e-2)" "unprognostic (4.12e-2)" "unprognostic (4.78e-2)" 20.2 13.6 48.2 3.3 53.0 2.3 16.3 95.8 256.5 15.5 7.7 9.7 1.9 9.4 2.2 8.6 21.7 4.8 95.4 45.0 97.2 8.3 8.5 11.1 3.0 120.4 67.0 7.8 12.3 18.2 17.4 5.3 115.7 8.7 2.7 10.7 15.4 3.6 572.0 6.3 8.0 4.5 52.2 19.8 8.4 2.8 153.5 1.3 11.1 227.8 0.8 13.4 10.5 113.6 0.4 17.5 0.2 1.0 5.2 7.8 0.1 7.1 6.1 3.4 0.9 0.7 0.2 0.2 12.7 7.1 3.0 0.3 1.1 0.7 1.6 0.2 0.8 0.2 2.5 4.5 6.9 0.1 0.1 2.5 0.1 0.4 0.2 6.8 11.6 0.2 0.4 0.1 2.2 1.7 0.2 0.2 0.8 1.6 5.1 0.9 1.8 0.2 0.5 0.1 8.1 4.3 0.9 0.1 1.4 0.6 1.6 0.4 26.1 6.7 6.6 0.3 4.6 0.3 0.5 1.0 4.0 0.8 4.8 0.7 0.2 0.1 0.3 0.1 0.6 0.1 0.1 0.1 0.6 0.2 0.1 0.1 0.7 0.2 0.1 0.1 0.3 0.7 48.2 53.0 95.8 256.5 45.0 97.2 120.4 67.0 115.7 52.2 153.5 113.6 12.8 0.0 3.3 11.8 1.1 1.8 0.8 1.6 0.0 67.9 1.6 7.7 20.3 0.0 0.6 0.0 2.1 0.4 2.9 0.0 9.8 0.3 0.3 2.0 2.0 9.7 0.0 0.4 50.4 2.6 0.6 9.9 2.0 1.8 2.5 0.1 20.7 1.2 31.3 8.4 48.3 1.6 0.0 35.1 3.7 0.0 7.5 29.5 3.6 15.9 3.0 13.3 0.0 6.0 18.5 0.7 0.1 2.2 2.7 1.1 0.1 2.5 1.0 22.8 0.0 25.3 3.6 0.2 0.7 0.1 1.1 1.0 2.0 0.1 0.8 0.3 SCN2A "HBSCI, HBSCII, Nav1.2, SCN2A1, SCN2A2" ENSG00000136531 "Sodium voltage-gated channel alpha subunit 2" Q99250 2 165194993-165392310 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Sodium transport, Transport" "Ion channel, Sodium channel, Voltage-gated channel" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "brain: 26.1" "Group enriched" "Detected in some" 5 "Excitatory neurons: 440.4;Inhibitory neurons: 364.7;Oligodendrocyte precursor cells: 246.3" "Cancer enhanced" "Detected in single" "glioma: 1.3" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HSkMC: 2.1;U-138 MG: 3.4;U-266/84: 8.1;U-87 MG: 2.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB022567 Enhanced NA NA "Cluster 6: Brain - Smell perception" "Cluster 16: U-266 - Nucleosome" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "CAB022567: " "unprognostic (1.16e-1)" "unprognostic (3.56e-4)" "unprognostic (5.28e-2)" "unprognostic (6.12e-3)" "unprognostic (2.97e-1)" "unprognostic (8.62e-3)" "unprognostic (1.18e-1)" "unprognostic (7.25e-3)" "unprognostic (1.40e-1)" "unprognostic (2.78e-1)" "unprognostic (1.32e-2)" "unprognostic (5.21e-2)" "unprognostic (3.44e-2)" "unprognostic (1.76e-1)" "unprognostic (1.05e-1)" "unprognostic (4.88e-2)" "unprognostic (2.14e-1)" 0.2 1.3 15.8 0.1 17.5 0.0 0.7 26.1 20.1 0.2 0.0 0.1 0.2 0.5 0.9 0.0 0.1 0.8 0.1 22.2 8.0 3.5 0.1 0.2 0.0 0.0 0.0 0.2 0.1 0.0 3.7 0.1 0.0 0.1 0.1 4.6 0.2 0.4 0.0 0.0 0.2 0.6 0.0 0.1 0.3 0.3 2.5 0.3 0.0 0.0 0.0 0.1 0.3 5.8 0.0 0.0 0.3 0.0 0.1 0.4 0.0 0.0 1.7 0.0 1.6 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.3 0.0 0.7 0.4 0.0 0.2 0.0 0.3 0.0 0.1 2.1 0.0 0.1 0.0 1.5 0.0 0.0 0.0 0.2 0.9 0.0 0.1 0.0 1.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.8 1.9 0.0 0.0 0.0 0.7 0.0 0.0 0.0 3.4 0.2 0.2 0.0 0.3 8.1 0.0 2.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.8 17.5 26.1 20.1 22.2 8.0 0.0 0.0 0.0 0.0 2.5 5.8 0.1 0.0 1.7 18.3 0.5 0.3 0.1 0.2 0.0 49.8 0.3 4.7 0.8 0.0 0.0 11.0 47.9 0.1 0.2 0.0 5.9 0.2 1.6 0.1 2.3 0.3 0.0 0.0 440.4 0.0 0.0 0.7 0.0 0.0 0.0 0.2 0.0 0.0 0.0 15.2 364.7 0.0 0.0 0.0 0.0 1.4 1.2 0.0 0.0 60.9 0.0 3.4 0.0 246.3 17.0 0.3 0.0 6.0 0.0 0.0 0.0 0.3 0.0 4.3 0.0 0.0 0.6 0.0 0.9 0.1 0.1 0.0 0.4 1.0 0.0 0.0 SCN3A Nav1.3 ENSG00000153253 "Sodium voltage-gated channel alpha subunit 3" Q9NY46 2 165087526-165204050 "Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted membrane proteins, Voltage-gated ion channels" "Ion transport, Sodium transport, Transport" "Ion channel, Sodium channel, Voltage-gated channel" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "brain: 16.9" "Cell type enhanced" "Detected in some" "Early spermatids: 78.4;Excitatory neurons: 227.3;Inhibitory neurons: 169.4;Oligodendrocyte precursor cells: 358.4" "Cancer enriched" "Detected in some" 6 "glioma: 3.4" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 30 "memory B-cell: 13.2;naive B-cell: 15.3" "Lineage enriched" "Detected in single" 32 "B-cells: 15.3" "Cell line enhanced" "Detected in some" "JURKAT: 5.9;Karpas-707: 10.3;MOLT-4: 30.3;RPTEC TERT1: 14.9;SH-SY5Y: 6.7" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA035396 Uncertain NA NA "Cluster 37: B-cells - Transcription" "Cluster 65: Brain - Ion transport" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA035396: AB_2674607" "unprognostic (1.80e-3)" "unprognostic (1.84e-2)" "unprognostic (1.20e-3)" "unprognostic (1.50e-2)" "unprognostic (6.69e-2)" "unprognostic (1.10e-2)" "unprognostic (4.96e-4)" "unprognostic (2.46e-1)" "unprognostic (1.48e-1)" "unprognostic (1.90e-1)" "unprognostic (1.21e-4)" "unprognostic (4.55e-2)" "unprognostic (5.87e-3)" "unprognostic (2.88e-2)" "unprognostic (6.85e-2)" "unprognostic (2.66e-1)" "unprognostic (4.93e-2)" 1.0 1.5 10.9 0.5 10.9 0.2 1.0 7.2 12.1 0.6 0.0 0.6 0.3 0.4 0.1 0.4 0.4 0.5 0.6 10.1 16.9 0.5 0.2 0.2 0.8 6.0 8.8 0.6 0.5 0.4 0.1 0.1 9.2 0.2 0.7 1.0 0.1 0.4 0.9 0.0 0.5 0.5 3.0 0.5 0.9 0.5 13.4 3.1 0.2 0.6 1.2 0.5 0.0 6.5 0.0 0.2 2.7 0.0 0.0 0.1 0.0 0.0 0.3 0.6 2.0 0.0 0.1 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.3 0.1 0.1 0.1 0.0 0.0 0.0 0.6 0.1 0.0 0.0 0.0 4.9 0.0 5.9 0.0 10.3 0.1 0.0 30.3 0.0 0.0 0.1 2.4 0.1 1.3 0.0 14.9 0.0 3.8 6.7 0.0 0.0 0.0 0.1 0.0 0.1 0.0 2.2 0.1 0.8 0.0 1.4 0.6 0.0 0.7 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 13.2 0.0 0.0 0.0 15.3 0.1 0.0 0.0 0.2 0.0 0.4 0.1 0.1 10.9 10.9 7.2 12.1 10.1 16.9 6.0 8.8 9.2 3.0 13.4 6.5 0.9 0.0 0.5 8.5 6.5 0.0 0.2 0.0 0.6 4.4 0.1 0.4 6.5 0.0 0.0 1.8 12.5 0.0 0.0 0.0 0.0 0.2 78.4 0.0 0.0 2.9 8.9 0.0 227.3 0.0 0.0 0.5 1.1 0.0 0.0 0.3 0.0 0.2 0.1 5.0 169.4 1.2 0.0 0.0 0.3 11.5 0.3 0.2 1.8 19.7 0.0 0.3 0.0 358.4 9.2 0.1 0.0 0.7 5.3 0.0 0.0 0.0 0.0 0.8 13.1 0.3 31.8 0.7 2.4 0.0 0.1 0.0 0.1 0.3 0.1 0.1 SCN4A "HYKPP, HYPP, Nav1.4, SkM1" ENSG00000007314 "Sodium voltage-gated channel alpha subunit 4" P35499 17 63938554-63972918 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Sodium transport, Transport" "Ion channel, Sodium channel, Voltage-gated channel" "Congenital myasthenic syndrome, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "skeletal muscle: 137.4;tongue: 54.0" "Cell type enriched" "Detected in some" 6 "Adipocytes: 46.4" "Cancer enhanced" "Detected in some" "thyroid cancer: 2.2" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 11 "REH: 15.0;RH-30: 45.0" "Not detected" "Not detected" "Not detected" "Not detected" HPA053992 Approved "Nucleoplasm,Centriolar satellite" NA NA "Cluster 33: Striated muscle - Muscle contraction" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Nucleoplasm "Centriolar satellite" "HPA053992: AB_2797249" "unprognostic (2.47e-1)" "unprognostic (1.74e-1)" "unprognostic (1.57e-2)" "unprognostic (1.78e-3)" "unprognostic (2.80e-2)" "unprognostic (1.63e-2)" "unprognostic (3.87e-4)" "unprognostic (3.84e-3)" "unprognostic (1.61e-1)" "unprognostic (1.36e-1)" "unprognostic (1.59e-3)" "unprognostic (3.15e-2)" "unprognostic (2.70e-2)" "unprognostic (4.38e-3)" "unprognostic (3.46e-1)" "unprognostic (4.15e-1)" "unprognostic (6.45e-2)" 17.9 0.7 0.0 0.2 0.1 0.0 16.0 0.3 0.1 0.1 0.0 1.1 0.0 0.1 0.0 1.1 0.2 0.3 0.8 0.0 0.0 0.7 0.1 0.0 0.4 0.0 0.0 0.2 0.2 0.7 1.5 0.1 0.0 0.5 0.1 0.0 1.8 0.0 137.4 0.7 0.3 0.0 0.0 0.8 0.5 1.7 0.0 0.2 4.3 54.0 0.1 0.5 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.0 1.5 0.0 0.0 15.0 45.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 2.8 1.4 1.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 46.4 0.0 0.0 0.0 0.6 0.3 0.0 0.0 0.0 0.0 0.2 0.3 1.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 3.5 0.0 0.0 2.3 0.0 0.0 0.2 0.0 0.0 0.3 0.0 0.1 0.0 1.1 2.2 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 4.6 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 7.1 5.9 0.3 0.3 0.0 0.1 0.0 0.1 0.0 0.0 0.0 SCN8A "CerIII, CIAT, MED, NaCh6, Nav1.6, PN4" ENSG00000196876 "Sodium voltage-gated channel alpha subunit 8" Q9UQD0 12 51590266-51812864 "Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Sodium transport, Transport" "Ion channel, Sodium channel, Voltage-gated channel" "Disease variant, Epilepsy, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 4 "brain: 35.0" "Group enriched" "Detected in many" 8 "Excitatory neurons: 336.7;Inhibitory neurons: 280.1;Oligodendrocyte precursor cells: 104.5" "Low cancer specificity" "Detected in some" "Region enhanced" "Detected in many" "cerebral cortex: 35.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 13.7;ASC TERT1: 13.5;WM-115: 13.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022169, HPA043937, HPA073590" Approved "Vesicles,Plasma membrane,Cell Junctions" NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" "Vesicles, Cell Junctions" "CAB022169: , HPA043937: , HPA073590: " "unprognostic (2.96e-2)" "unprognostic (8.49e-2)" "unprognostic (6.93e-2)" "unprognostic (3.52e-6)" "unprognostic (8.13e-2)" "unprognostic (1.51e-2)" "unprognostic (1.16e-1)" "unprognostic (7.77e-2)" "unprognostic (5.44e-2)" "unprognostic (1.16e-1)" "unprognostic (4.73e-4)" "unprognostic (1.69e-2)" "unprognostic (1.29e-5)" "unprognostic (4.38e-1)" "unprognostic (1.56e-1)" "unprognostic (2.37e-1)" "unprognostic (4.75e-2)" 0.2 1.0 5.6 0.4 8.9 0.7 0.5 2.5 35.0 0.4 0.0 0.7 0.2 0.4 0.7 0.1 0.2 0.9 0.1 11.4 0.2 0.9 2.6 0.1 0.4 4.2 0.0 0.5 1.6 0.5 6.7 0.1 3.8 0.6 0.9 7.9 0.6 0.2 0.3 0.3 0.2 0.1 0.0 0.6 1.0 1.7 2.4 0.5 0.5 0.1 0.2 0.2 0.2 11.5 1.7 1.3 13.7 0.2 1.8 13.5 0.3 8.0 12.5 9.1 8.5 2.8 1.6 0.4 1.9 9.9 4.4 0.1 2.3 0.0 10.5 1.6 0.8 0.1 0.3 0.3 0.1 0.2 1.1 1.8 0.0 6.5 1.4 3.4 9.8 3.5 0.2 0.2 5.5 1.0 2.5 0.2 4.9 0.9 4.8 0.1 0.7 0.0 0.0 0.5 5.6 2.2 4.5 2.1 0.3 2.1 0.4 0.2 2.8 8.9 6.3 3.3 5.2 0.2 0.1 0.0 1.8 1.9 13.0 0.5 0.0 0.1 0.1 0.0 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.4 0.1 0.0 0.1 0.0 0.0 5.6 8.9 2.5 35.0 11.4 0.2 4.2 0.0 3.8 0.0 2.4 11.5 1.2 0.0 0.0 27.1 0.0 0.0 0.5 0.0 3.4 16.7 2.6 1.8 1.4 1.5 0.0 0.0 10.4 0.0 0.3 1.0 0.0 0.5 0.6 0.0 0.7 1.3 11.4 0.0 336.7 0.5 0.0 0.1 3.1 0.0 0.0 0.7 1.1 4.3 0.0 5.0 280.1 1.3 0.0 0.0 0.0 0.7 0.0 0.0 0.0 20.6 0.0 4.7 0.0 104.5 14.2 0.7 0.5 0.7 0.0 0.4 0.0 0.7 0.0 11.2 0.0 0.4 0.3 3.8 10.2 0.1 0.0 0.0 0.3 0.0 0.9 0.3 SCN9A "ETHA, Nav1.7, NE-NA, NENA, PN1" ENSG00000169432 "Sodium voltage-gated channel alpha subunit 9" Q15858 2 166195185-166376001 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Sodium transport, Transport" "Ion channel, Sodium channel, Voltage-gated channel" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 4 "brain: 21.9" "Cell type enhanced" "Detected in many" "dendritic cells: 43.2;Hofbauer cells: 67.5;Inhibitory neurons: 48.2;Langerhans cells: 42.8;Oligodendrocyte precursor cells: 133.7" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in some" 16 "plasmacytoid DC: 23.6" "Lineage enriched" "Detected in single" 26 "dendritic cells: 23.6" "Cell line enhanced" "Detected in many" "BJ: 23.0;BJ hTERT+: 16.8;HHSteC: 19.0;hTERT-RPE1: 15.6" "Region enriched" "Detected in many" 5 "hypothalamus: 9.3" "Low region specificity" "Detected in many" "CAB013679, HPA061843" Uncertain Approved "Plasma membrane,Actin filaments,Focal adhesion sites" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 68: Oligodendrocytes - Mixed function" "Plasma membrane, Actin filaments, Focal adhesion sites" "CAB013679: , HPA061843: AB_2684625" "unprognostic (2.10e-1)" "unprognostic (2.83e-1)" "unprognostic (1.13e-1)" "unprognostic (8.98e-5)" "unprognostic (1.47e-3)" "unprognostic (9.43e-3)" "unprognostic (2.28e-2)" "unprognostic (2.24e-1)" "unprognostic (2.23e-1)" "unprognostic (3.64e-1)" "unprognostic (1.45e-1)" "unprognostic (2.27e-1)" "prognostic unfavorable (2.30e-5)" "unprognostic (1.69e-3)" "unprognostic (6.74e-2)" "unprognostic (2.46e-2)" "unprognostic (2.46e-1)" 1.7 1.7 5.3 0.9 4.2 2.0 0.6 0.1 3.4 0.6 0.0 3.2 0.5 0.2 0.1 0.5 0.4 1.2 0.4 2.9 21.9 1.7 3.9 2.0 0.6 8.2 19.4 0.3 2.0 0.1 1.5 4.3 12.0 0.3 3.1 0.7 0.4 0.4 0.2 0.7 1.8 2.4 2.2 3.1 0.4 5.1 18.2 1.6 0.3 0.6 0.4 0.5 0.5 1.7 0.0 2.5 0.1 0.0 9.6 7.9 0.0 23.0 16.8 5.2 1.7 0.5 0.1 0.0 0.0 2.8 0.2 0.1 6.5 0.6 8.6 0.0 2.1 1.7 1.8 1.9 19.0 0.1 0.0 0.6 0.2 9.1 1.7 15.6 1.1 1.2 6.1 6.6 0.8 0.0 3.6 0.0 1.9 0.1 0.6 0.8 3.3 9.0 2.4 9.5 1.0 9.5 0.0 0.1 0.3 4.8 0.3 0.0 0.1 0.0 1.5 0.1 0.4 0.1 0.1 0.0 3.2 0.0 2.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.9 0.5 0.1 23.6 0.0 0.1 5.3 4.2 0.1 3.4 2.9 21.9 8.2 19.4 12.0 2.2 18.2 1.7 0.9 12.8 23.8 0.7 1.3 1.0 0.4 0.5 0.6 0.6 0.8 0.9 2.5 8.6 4.4 5.5 0.0 0.3 43.2 9.0 3.9 23.4 2.5 0.1 0.1 5.7 33.0 4.2 15.8 31.5 0.3 2.0 0.0 0.1 3.8 18.1 13.6 9.5 67.5 0.0 48.2 19.3 10.2 1.9 42.8 3.2 1.2 11.3 3.6 2.8 1.0 2.3 0.0 133.7 0.4 12.7 7.8 0.0 1.2 0.3 14.7 11.5 2.2 0.2 0.0 7.8 1.6 1.3 0.4 0.5 0.4 1.1 0.9 4.4 12.9 0.2 SCO2 "MYP6, SCO1L" ENSG00000284194 "Synthesis of cytochrome C oxidase 2" O43819 22 50523568-50526461 "Disease related genes, Human disease related genes, Predicted membrane proteins" Chaperone "Cardiomyopathy, Disease variant, Leigh syndrome, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 112.2;Paneth cells: 131.5;Proximal enterocytes: 110.7;Suprabasal keratinocytes: 98.9" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046943, HPA056254" Uncertain Approved Mitochondria NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" Mitochondria "HPA046943: AB_2732536, HPA056254: AB_2683080" 16.8 10.3 14.0 13.4 13.8 36.5 7.8 14.4 16.8 6.8 18.2 22.0 25.6 3.6 4.7 12.3 15.8 7.7 10.3 14.3 14.4 8.1 18.4 14.4 9.1 18.8 19.1 1.8 11.5 7.2 1.5 8.3 17.5 5.1 10.5 0.1 21.3 6.7 10.2 11.0 19.7 12.7 16.4 11.4 10.2 4.1 17.4 11.2 2.3 10.1 10.3 13.0 2.5 17.4 37.4 29.9 1.3 12.5 17.7 24.2 18.7 19.5 24.1 38.0 32.8 35.3 17.8 42.7 19.7 22.6 9.6 36.0 19.3 31.5 6.1 7.6 82.5 13.8 20.2 46.7 44.6 43.8 18.3 38.4 48.6 19.4 15.8 10.6 24.4 5.8 15.6 32.9 16.8 55.7 13.3 76.5 11.0 15.5 54.8 26.1 7.5 65.0 29.6 21.3 16.6 23.7 24.4 70.7 63.5 1.3 26.1 24.7 25.8 16.3 22.6 30.2 22.2 26.1 15.6 29.2 35.7 28.7 14.5 19.1 21.8 12.2 43.9 19.9 42.2 40.1 38.9 44.1 34.9 33.4 29.2 32.6 21.6 27.7 21.1 56.2 37.0 37.7 14.0 13.8 14.4 16.8 14.3 14.4 18.8 19.1 17.5 16.4 17.4 17.4 0.0 3.2 2.7 2.9 20.0 85.7 21.6 75.5 44.3 7.3 0.1 0.0 16.8 21.5 31.4 0.0 2.1 0.0 5.3 112.2 0.0 0.0 15.1 0.1 0.2 13.8 25.8 14.1 2.7 0.0 0.0 14.1 24.5 0.1 15.9 0.0 18.2 53.5 0.0 11.8 2.7 63.2 48.8 28.2 63.6 25.6 16.4 29.2 42.7 5.6 47.3 5.5 25.7 5.5 1.4 0.1 131.5 10.9 32.1 40.0 110.7 0.1 42.6 7.1 0.0 30.4 29.5 17.3 35.7 56.1 98.9 0.0 14.9 0.1 90.7 22.3 SCP2 ENSG00000116171 "Sterol carrier protein 2" P22307 1 52927276-53051698 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Lipid transport, Transport" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 1116.8" "Cell type enhanced" "Detected in all" "Hepatocytes: 1240.7;Proximal enterocytes: 769.0;Proximal tubular cells: 881.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027101, HPA027135, HPA027317" Supported Supported Nucleoplasm,Peroxisomes NA NA 640000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 2: Hepatocytes - Metabolism" Peroxisomes Nucleoplasm "HPA027101: AB_1856634, HPA027135: AB_1856633, HPA027317: AB_10610422" "unprognostic (7.51e-2)" "unprognostic (5.23e-2)" "prognostic favorable (7.05e-5)" "unprognostic (9.68e-2)" "unprognostic (1.53e-2)" "unprognostic (5.53e-2)" "unprognostic (1.87e-3)" "unprognostic (1.22e-2)" "unprognostic (1.62e-2)" "unprognostic (1.59e-1)" "unprognostic (4.53e-2)" "unprognostic (6.16e-2)" "prognostic favorable (7.85e-8)" "unprognostic (1.49e-2)" "unprognostic (1.09e-1)" "unprognostic (8.64e-2)" "unprognostic (1.13e-2)" 203.7 125.5 68.5 92.7 71.6 111.2 196.6 74.2 90.1 153.8 79.2 256.7 336.3 94.6 165.5 140.2 119.7 144.6 162.4 65.8 76.1 319.8 1116.8 140.6 106.0 75.4 72.3 94.5 119.2 130.9 64.7 79.0 77.9 150.9 270.5 76.6 114.0 97.3 142.0 130.6 305.7 112.9 75.6 83.9 234.4 63.4 74.7 131.9 140.9 152.8 125.5 139.2 76.9 78.9 120.6 64.8 85.5 157.9 273.6 232.6 92.7 140.0 208.9 90.1 129.2 58.7 127.5 114.7 147.6 206.6 105.3 82.5 59.6 131.0 136.5 168.2 86.4 123.4 88.8 122.1 182.0 179.9 197.5 190.2 175.0 107.1 52.9 196.2 260.0 132.6 111.5 58.2 184.7 70.1 200.7 155.2 94.6 304.4 126.0 101.9 150.9 158.3 252.2 192.2 70.9 85.3 122.0 246.3 121.6 189.6 125.9 201.4 203.8 122.4 63.4 213.2 114.9 95.9 131.0 134.2 159.0 175.7 113.8 285.6 193.7 286.0 185.9 208.8 152.1 150.8 144.9 184.6 230.5 132.6 120.8 171.4 29.4 176.8 204.2 150.9 195.2 289.5 68.5 71.6 74.2 90.1 65.8 76.1 75.4 72.3 77.9 75.6 74.7 78.9 167.0 134.6 198.4 52.2 91.1 150.4 123.8 222.2 110.4 37.5 189.8 86.0 157.4 258.7 166.2 185.8 31.3 182.7 128.3 512.7 473.5 168.1 57.4 150.4 81.6 126.8 235.1 93.4 45.0 162.4 156.5 124.3 180.4 125.3 138.4 54.0 146.7 1240.7 203.5 42.1 54.4 462.7 250.3 230.1 173.1 51.4 184.2 148.8 192.1 42.2 154.6 132.0 181.3 48.2 44.3 157.4 503.4 171.9 76.6 118.1 769.0 881.0 178.2 34.1 78.9 72.0 110.6 20.4 19.4 150.0 170.8 133.9 132.9 110.3 336.4 187.8 SCYL1 "GKLP, HT019, MGC78454, NKTL, NTKL, P105, TAPK, TEIF, TRAP" ENSG00000142186 "SCY1 like pseudokinase 1" Q96KG9 11 65525077-65538704 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "ER-Golgi transport, Transcription, Transcription regulation, Transport" "Activator, DNA-binding" "Mental retardation, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 138.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015015 Uncertain Supported Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 55: Plasma cells - Humoral immune response" Cytosol "HPA015015: AB_1856643" "unprognostic (5.56e-2)" "unprognostic (1.16e-1)" "unprognostic (1.03e-1)" "unprognostic (3.99e-1)" "unprognostic (1.23e-2)" "unprognostic (7.87e-2)" "unprognostic (1.23e-2)" "unprognostic (5.06e-2)" "unprognostic (1.14e-1)" "unprognostic (7.23e-2)" "unprognostic (4.41e-1)" "unprognostic (4.29e-1)" "unprognostic (7.86e-3)" "unprognostic (6.49e-3)" "unprognostic (4.27e-1)" "unprognostic (8.29e-2)" "unprognostic (2.29e-3)" 43.4 69.3 36.6 26.4 37.4 32.8 41.1 33.1 53.9 46.8 37.1 46.7 28.0 49.4 32.5 40.0 44.0 26.3 59.7 39.2 34.1 45.7 83.2 42.4 30.7 36.0 35.2 52.4 61.6 35.5 44.7 34.6 35.5 47.3 17.2 12.4 48.5 33.7 104.5 44.5 39.6 27.5 30.9 46.4 50.0 50.6 37.7 23.4 48.8 51.6 21.8 47.8 39.5 39.0 55.0 45.9 36.6 50.9 65.4 56.6 50.0 66.6 89.4 77.7 60.4 66.9 32.2 39.2 65.7 86.9 66.2 49.1 38.7 50.1 27.0 46.6 49.7 46.4 50.8 78.3 92.8 30.8 64.0 79.1 48.6 66.9 49.4 54.2 51.6 39.7 49.2 53.8 49.0 118.9 41.4 70.4 35.3 36.9 63.4 41.4 28.5 72.5 48.1 48.4 33.7 35.7 41.2 89.6 74.5 22.4 88.8 38.4 51.4 61.3 41.0 100.7 40.1 73.8 55.8 41.4 71.0 25.3 43.7 2.9 21.1 28.4 20.7 20.0 16.6 14.0 19.6 20.9 23.5 14.3 15.2 15.0 41.9 18.2 13.6 17.0 14.4 19.8 36.6 37.4 33.1 53.9 39.2 34.1 36.0 35.2 35.5 30.9 37.7 39.0 22.7 19.2 16.7 11.4 25.7 21.9 29.8 30.9 25.0 25.4 29.9 20.1 5.8 21.5 26.0 20.2 12.5 64.6 18.5 47.4 37.2 37.5 25.7 17.3 22.7 23.7 30.5 22.3 14.6 43.4 70.0 34.1 38.2 25.4 25.4 34.0 22.1 35.0 38.1 16.8 12.8 39.9 28.5 19.2 24.3 25.2 45.7 24.5 30.2 11.2 34.3 26.6 21.6 6.6 10.5 36.4 31.4 45.5 53.4 44.8 50.8 37.2 15.3 22.0 13.1 24.4 33.8 39.5 21.8 27.5 23.2 138.6 23.2 44.3 36.2 38.5 SELENOI "EPT1, KIAA1724, SELI, SEPI" ENSG00000138018 "Selenoprotein I" Q9C0D9 2 26308547-26395891 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" Transferase "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Collecting duct cells: 22.0;Endometrial ciliated cells: 16.3;Glandular and luminal cells: 15.3;Pancreatic endocrine cells: 13.6;Syncytiotrophoblasts: 16.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA064125 Approved NA NA "Cluster 37: B-cells - Transcription" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" "HPA064125: " "unprognostic (6.29e-2)" "unprognostic (7.46e-2)" "unprognostic (1.38e-3)" "unprognostic (3.05e-3)" "unprognostic (1.50e-1)" "unprognostic (1.39e-2)" "unprognostic (7.44e-3)" "unprognostic (5.00e-3)" "unprognostic (7.79e-2)" "unprognostic (2.55e-2)" "unprognostic (6.65e-2)" "unprognostic (9.40e-2)" "unprognostic (1.52e-2)" "unprognostic (2.95e-1)" "unprognostic (1.76e-1)" "unprognostic (9.87e-3)" "unprognostic (1.42e-2)" 3.6 6.4 7.9 5.5 8.4 12.1 8.1 11.2 10.6 5.4 5.0 8.6 12.3 4.1 5.4 11.1 3.5 4.0 3.9 10.3 9.3 7.9 23.2 4.4 5.7 6.8 7.3 3.5 9.0 17.2 4.5 4.7 8.6 6.2 8.7 9.3 6.2 4.2 7.0 18.3 18.4 3.7 9.7 4.3 7.1 4.4 7.2 6.3 7.1 6.6 6.1 7.5 7.1 10.0 42.7 25.7 20.9 21.0 12.8 10.2 32.0 20.3 9.2 10.0 10.2 54.5 26.6 49.5 24.2 9.5 21.4 34.1 32.4 17.9 14.4 13.7 15.4 31.3 17.5 32.3 12.2 41.9 9.7 8.1 15.6 22.3 21.9 6.1 9.4 17.6 35.9 16.6 13.5 18.4 25.1 20.7 26.8 21.6 17.4 22.6 49.2 25.0 19.3 32.4 45.7 19.4 17.3 36.2 16.4 17.3 17.4 12.4 15.1 17.1 22.0 22.7 31.7 22.6 60.8 65.8 17.5 25.4 15.6 0.0 0.7 0.0 0.9 1.0 0.9 2.5 0.9 1.2 0.7 1.0 1.2 2.0 0.2 0.9 0.9 1.3 1.8 0.4 7.9 8.4 11.2 10.6 10.3 9.3 6.8 7.3 8.6 9.7 7.2 10.0 9.1 12.8 8.7 0.0 3.0 0.0 0.0 0.0 0.0 0.0 12.2 7.1 0.0 0.0 3.1 22.0 0.0 6.1 11.7 0.0 0.0 10.4 0.0 16.3 12.8 3.7 0.0 0.0 0.0 10.4 6.2 2.9 0.0 15.3 1.3 8.6 0.0 0.0 6.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.6 0.0 0.0 0.0 0.0 13.6 0.0 0.0 3.9 0.0 0.0 5.6 2.2 0.0 0.0 0.0 3.5 0.0 0.0 0.0 0.0 16.6 4.7 11.5 0.0 0.0 SEMA4A "CORD10, FLJ12287, SEMAB, SemB" ENSG00000196189 "Semaphorin 4A" Q9H3S1 1 156147366-156177752 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Adaptive immunity, Angiogenesis, Differentiation, Immunity, Neurogenesis" "Developmental protein" "Cone-rod dystrophy, Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "epididymis: 51.3" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 63.7;Plasma cells: 61.2;Skeletal myocytes: 100.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "classical monocyte: 123.9;eosinophil: 120.2;intermediate monocyte: 132.7;myeloid DC: 183.0;neutrophil: 210.7;non-classical monocyte: 76.1" "Group enriched" "Detected in all" 13 "dendritic cells: 183.0;granulocytes: 210.7;monocytes: 132.7" "Cell line enhanced" "Detected in many" "Karpas-707: 151.8;U-698: 67.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA069136 Supported NA NA 3300000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 27: Brain & Skin - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 7: Non-specific - Mitochondria" "HPA069136: AB_2686093" "unprognostic (1.90e-1)" "unprognostic (2.39e-2)" "unprognostic (4.24e-1)" "unprognostic (5.20e-2)" "unprognostic (8.04e-2)" "prognostic favorable (1.09e-4)" "unprognostic (1.97e-1)" "unprognostic (2.50e-2)" "unprognostic (3.51e-1)" "unprognostic (1.60e-2)" "unprognostic (1.51e-1)" "unprognostic (2.50e-1)" "prognostic unfavorable (8.20e-4)" "unprognostic (8.77e-2)" "unprognostic (4.63e-2)" "unprognostic (6.06e-2)" "unprognostic (1.28e-2)" 6.1 1.0 22.7 24.8 21.5 37.5 9.1 6.1 23.2 10.8 4.7 6.9 3.6 3.0 51.3 32.5 7.9 8.8 3.0 25.3 23.0 18.1 2.1 15.2 31.5 12.2 15.5 5.2 4.0 1.5 3.6 1.8 15.3 16.3 6.1 2.0 19.2 12.5 3.1 32.3 4.8 3.6 11.4 26.9 10.6 4.1 29.0 8.1 23.1 2.2 33.1 10.8 17.4 13.1 12.6 0.0 0.5 0.0 0.0 0.9 0.3 0.2 0.4 0.1 0.2 0.1 0.3 8.1 0.3 0.6 0.1 11.7 0.9 10.0 0.4 3.5 0.0 0.4 0.2 0.4 0.4 18.5 1.1 0.6 9.2 0.2 0.4 2.3 0.9 2.8 1.3 151.8 0.5 15.2 0.1 6.5 3.6 12.4 0.0 0.6 0.3 5.4 17.9 24.1 0.1 0.3 0.0 19.2 1.0 1.7 22.3 23.3 0.9 0.0 0.1 0.0 0.0 29.3 3.0 67.6 0.5 17.5 0.4 16.0 123.9 120.2 4.0 132.7 8.5 13.2 1.3 8.0 183.0 10.9 0.2 1.3 210.7 4.3 76.1 25.7 1.4 66.4 22.7 21.5 6.1 23.2 25.3 23.0 12.2 15.5 15.3 11.4 29.0 13.1 13.6 19.2 63.7 25.8 13.9 23.5 22.5 25.8 24.5 1.9 28.3 27.6 5.9 14.3 13.8 40.5 0.0 0.9 9.8 6.5 1.9 6.1 6.4 12.9 21.6 9.5 3.6 1.3 7.5 0.7 0.4 20.9 22.4 33.5 17.7 0.6 9.3 0.6 15.4 0.0 5.2 24.1 8.2 22.8 42.1 4.3 1.8 37.8 16.0 1.0 32.6 6.3 2.1 1.0 1.0 1.1 7.2 1.2 61.2 14.2 0.8 0.7 9.6 0.4 0.0 100.1 11.3 3.1 0.7 39.0 27.6 1.8 10.0 1.4 17.6 15.6 SEPTIN9 "AF17q25, KIAA0991, MSF, MSF1, PNUTL4, SEPT9, SeptD1" ENSG00000184640 "Septin 9" Q9UHD8 17 77280569-77500596 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Adipocytes: 29.9;Cytotrophoblasts: 78.2;dendritic cells: 34.8;Extravillous trophoblasts: 152.8;Hofbauer cells: 67.5;Syncytiotrophoblasts: 70.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042564, HPA050627" Approved Enhanced "Actin filaments" No No 770000 "Cluster 39: Non-specific - mRNA processing" "Cluster 3: T-cells - Adaptive immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" "Actin filaments" "HPA042564: AB_2678054, HPA050627: AB_2681193" "unprognostic (7.65e-2)" "unprognostic (5.44e-2)" "unprognostic (5.46e-3)" "unprognostic (2.34e-1)" "unprognostic (2.65e-2)" "unprognostic (2.71e-1)" "prognostic unfavorable (1.61e-5)" "unprognostic (4.23e-3)" "unprognostic (1.56e-1)" "unprognostic (8.48e-2)" "unprognostic (1.99e-1)" "unprognostic (2.45e-1)" "unprognostic (1.49e-2)" "unprognostic (1.25e-1)" "unprognostic (1.35e-1)" "unprognostic (1.33e-1)" "unprognostic (2.80e-1)" 68.7 87.9 58.8 148.8 61.7 89.2 72.8 81.6 85.3 99.3 59.9 137.8 94.9 127.5 27.0 81.9 89.0 88.3 70.5 68.1 68.6 75.2 99.5 77.8 223.8 111.5 62.0 76.4 38.7 67.2 63.3 80.7 76.6 96.0 51.9 15.6 76.8 75.6 73.1 80.3 145.1 84.5 68.2 152.8 103.1 60.0 65.7 260.2 52.9 43.1 151.5 122.9 82.4 71.8 246.1 342.0 221.3 186.4 257.0 417.1 121.7 188.9 214.1 122.4 89.0 278.4 243.4 338.7 153.4 388.5 161.2 149.1 96.6 354.8 90.4 6.2 65.0 128.8 147.3 483.2 212.0 84.6 218.3 215.6 128.8 159.6 136.0 180.3 167.5 196.4 144.6 44.1 110.7 258.1 628.1 72.0 207.5 281.4 281.1 290.7 192.6 117.1 197.5 337.9 171.0 324.3 214.2 349.6 207.2 248.6 260.2 60.7 243.6 165.8 147.6 197.4 130.2 10.5 19.5 562.6 245.6 73.7 348.7 4.2 18.4 31.1 22.3 46.3 19.0 16.3 28.7 26.4 17.0 17.4 29.6 25.8 6.1 16.9 55.3 38.7 31.8 24.9 58.8 61.7 81.6 85.3 68.1 68.6 111.5 62.0 76.6 68.2 65.7 71.8 29.9 0.0 0.0 0.0 6.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.5 0.0 0.0 0.0 0.0 78.2 34.8 0.0 0.0 0.0 0.0 0.0 0.0 5.9 0.0 0.0 0.0 0.0 152.8 9.4 0.0 0.0 0.0 0.0 0.0 0.0 67.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.7 0.0 0.0 0.0 0.0 70.6 6.8 0.0 0.0 0.0 SERPINB6 "CAP, DFNB91, PI6, PTI" ENSG00000124570 "Serpin family B member 6" P35237 6 2948159-2972165 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Protease inhibitor, Serine protease inhibitor" "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 563.0;Late spermatids: 1154.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA009668, HPA012736" Enhanced Approved Centrosome NA NA 4800000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 44: HDLM-2 - Immune response" "Cluster 31: Spermatids - Spermatogenesis" Centrosome "HPA009668: AB_1079919, HPA012736: AB_1856729" "unprognostic (3.44e-1)" "unprognostic (1.03e-1)" "unprognostic (8.72e-2)" "unprognostic (1.96e-3)" "unprognostic (2.72e-2)" "unprognostic (1.56e-2)" "unprognostic (1.66e-3)" "unprognostic (1.96e-2)" "unprognostic (7.63e-2)" "prognostic favorable (4.81e-4)" "unprognostic (3.51e-1)" "unprognostic (1.54e-1)" "prognostic unfavorable (2.21e-4)" "unprognostic (1.59e-1)" "unprognostic (5.08e-2)" "unprognostic (1.80e-1)" "unprognostic (1.10e-2)" 122.7 170.7 101.1 66.9 108.4 66.6 107.9 103.6 134.3 135.9 103.8 133.7 191.2 95.9 82.2 131.5 118.9 77.7 243.9 98.6 104.2 136.7 63.3 151.7 52.7 111.7 107.1 169.7 282.5 94.4 92.0 133.5 110.6 160.4 103.3 56.4 92.5 95.6 232.0 50.9 210.3 89.4 105.8 164.5 115.0 203.8 106.7 26.7 101.3 266.8 47.2 107.7 95.5 115.4 156.2 99.6 32.2 134.3 85.6 189.2 99.2 142.1 170.7 109.9 127.3 35.0 108.5 0.8 161.6 161.7 124.8 228.8 90.3 144.1 102.2 204.9 41.2 90.7 111.8 60.0 148.5 1.1 53.0 109.4 98.5 104.8 26.9 191.1 263.7 0.5 118.7 2.0 198.0 110.7 0.5 1.5 19.1 175.5 188.8 10.1 59.3 130.7 138.7 37.1 1.5 82.5 116.9 17.3 162.4 118.6 75.3 73.8 188.7 111.1 41.4 252.0 97.1 3.0 0.6 2.7 85.4 90.8 117.8 60.6 104.9 121.2 51.5 107.6 25.7 27.3 28.9 35.5 103.6 22.9 33.7 56.1 8.6 86.0 90.7 10.3 5.0 91.1 101.1 108.4 103.6 134.3 98.6 104.2 111.7 107.1 110.6 105.8 106.7 115.4 127.8 51.3 69.6 34.3 33.0 20.5 68.4 141.8 23.9 28.4 62.4 63.0 142.6 42.9 141.6 75.4 20.9 146.4 56.8 237.9 99.7 194.6 563.0 89.4 91.4 137.5 73.0 29.9 14.2 338.3 346.6 84.9 108.6 47.8 104.5 83.5 232.7 31.9 182.3 30.3 21.5 169.7 114.0 181.9 70.2 1154.3 83.3 124.2 64.0 92.8 151.8 172.4 46.4 31.7 56.2 318.5 237.0 85.0 17.4 99.3 418.3 216.4 174.2 50.4 78.9 119.7 104.6 233.2 33.1 34.0 26.3 161.4 42.2 65.0 206.5 94.9 SERPINI1 PI12 ENSG00000163536 "Serpin family I member 1" Q99574 3 167735243-167825569 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" "Protease inhibitor, Serine protease inhibitor" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 301.4" "Cell type enhanced" "Detected in many" "Bipolar cells: 219.4;Excitatory neurons: 176.9;Inhibitory neurons: 228.8;Oligodendrocytes: 174.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "Daudi: 29.2;Karpas-707: 29.1;U-266/84: 28.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001565, HPA056092" Enhanced Uncertain Cytosol "Secreted in brain" NA NA 750000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 65: Brain - Ion transport" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 56: Bipolar cells - Visual perception" Cytosol "HPA001565: AB_1079924, HPA056092: AB_2683036" "unprognostic (1.61e-1)" "unprognostic (1.06e-1)" "unprognostic (4.09e-3)" "unprognostic (1.35e-1)" "unprognostic (6.97e-2)" "unprognostic (1.47e-1)" "prognostic unfavorable (4.25e-4)" "unprognostic (2.48e-1)" "unprognostic (2.61e-1)" "unprognostic (6.07e-3)" "unprognostic (2.18e-2)" "unprognostic (1.01e-1)" "unprognostic (1.58e-3)" "unprognostic (1.41e-1)" "unprognostic (2.89e-1)" "unprognostic (1.22e-1)" "unprognostic (1.11e-1)" 13.1 15.8 138.8 4.1 157.7 2.3 11.7 115.9 301.4 8.4 82.1 5.1 2.2 8.6 8.2 5.5 7.9 6.3 14.0 162.0 129.1 32.1 4.1 6.4 4.6 122.8 153.6 6.9 39.5 6.9 42.8 6.7 123.9 11.8 4.4 84.4 23.0 7.4 3.2 3.1 4.4 6.1 134.6 8.7 10.8 15.8 134.5 4.4 11.2 8.1 8.2 4.9 6.0 164.8 0.8 3.5 5.5 0.4 10.3 2.2 0.3 1.9 2.7 1.3 2.2 1.5 5.9 29.2 9.5 1.3 4.5 1.3 3.9 3.8 1.5 7.7 6.5 8.9 22.5 10.7 0.7 1.4 1.1 3.8 1.4 0.8 1.3 2.9 0.4 10.5 18.9 29.1 1.2 2.7 0.8 1.9 3.3 4.2 4.5 2.7 0.4 3.2 11.2 1.0 2.2 13.4 3.6 6.8 8.3 12.4 10.6 4.4 1.0 5.5 0.5 0.5 10.3 23.0 28.4 18.8 4.2 7.7 3.2 1.5 0.3 0.8 9.3 0.7 6.9 22.1 9.7 10.2 0.5 25.2 6.9 8.1 0.9 9.5 0.5 7.2 27.2 5.2 138.8 157.7 115.9 301.4 162.0 129.1 122.8 153.6 123.9 134.6 134.5 164.8 49.8 6.4 1.5 43.1 10.7 3.7 13.2 6.4 14.2 219.4 3.6 14.1 8.2 1.5 6.7 5.5 14.6 6.1 6.2 0.7 7.9 1.8 0.4 2.0 1.0 16.0 4.8 7.4 176.9 18.0 6.0 8.9 2.6 1.7 2.5 2.3 3.9 0.6 2.3 5.0 228.8 0.3 73.2 0.6 3.2 2.4 4.1 0.9 7.2 25.3 1.2 78.0 2.1 31.2 174.7 3.0 0.0 2.6 14.6 6.7 0.0 39.9 13.6 35.4 26.3 5.2 54.7 3.0 27.4 0.5 1.7 5.1 6.2 1.1 0.3 2.3 SETX "ALS4, AOA2, KIAA0625, SCAR1, Sen1" ENSG00000107290 Senataxin Q7Z333 9 132261356-132354986 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Biological rhythms, Differentiation, DNA damage, DNA recombination, DNA repair, Neurogenesis, Spermatogenesis" "Helicase, Hydrolase" "Amyotrophic lateral sclerosis, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA024105, HPA057269" Approved Supported "Nucleoplasm,Cytokinetic bridge" Yes No "Cluster 6: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Nucleoplasm "Cytokinetic bridge" "HPA024105: AB_2671437, HPA057269: AB_2683389" "unprognostic (2.16e-1)" "unprognostic (5.77e-2)" "unprognostic (3.23e-1)" "unprognostic (2.03e-1)" "unprognostic (9.99e-2)" "unprognostic (2.14e-2)" "unprognostic (4.86e-2)" "unprognostic (1.64e-2)" "unprognostic (2.06e-2)" "unprognostic (1.38e-2)" "unprognostic (2.36e-1)" "unprognostic (3.32e-1)" "unprognostic (6.76e-3)" "unprognostic (2.47e-1)" "unprognostic (1.13e-1)" "unprognostic (5.64e-3)" "unprognostic (6.42e-2)" 13.7 9.5 6.2 19.9 8.8 16.8 13.9 9.8 6.3 13.2 7.7 13.1 10.6 12.7 11.1 10.6 10.9 12.7 10.5 5.1 7.8 11.9 16.7 15.4 27.4 8.7 7.0 13.0 9.2 18.3 6.0 14.3 9.6 13.0 12.8 13.2 9.0 12.7 12.9 12.3 13.2 12.8 8.0 27.6 12.9 31.9 7.7 25.4 33.0 12.8 26.3 15.7 8.5 13.2 15.1 19.9 22.5 24.4 28.3 34.1 13.5 19.6 21.9 15.6 14.6 21.1 16.8 25.6 9.4 36.9 38.3 30.2 22.8 17.0 17.0 24.6 9.9 26.9 22.7 18.4 26.5 41.8 31.2 24.0 26.2 26.6 23.6 19.1 25.4 17.8 31.7 20.0 18.3 21.8 25.9 15.8 24.2 25.4 15.4 24.2 32.6 17.2 17.1 19.5 14.0 21.4 32.4 14.2 18.2 29.7 19.7 21.2 29.3 32.5 14.0 22.1 19.0 12.2 22.0 38.6 14.9 16.3 17.8 10.5 4.4 4.7 5.3 4.1 5.6 5.5 3.9 4.1 3.3 6.9 4.2 3.7 15.1 5.2 4.9 5.0 3.2 2.3 6.2 8.8 9.8 6.3 5.1 7.8 8.7 7.0 9.6 8.0 7.7 13.2 76.2 60.9 45.7 75.1 85.6 30.2 34.6 26.6 38.7 31.2 24.1 22.7 61.3 17.2 43.9 20.2 29.2 13.7 96.8 37.6 3.9 20.0 7.6 62.7 68.0 58.7 14.5 25.5 73.7 14.7 10.6 52.9 44.4 89.7 58.2 38.3 51.4 33.0 28.8 67.3 64.8 30.6 16.2 73.1 37.6 13.8 30.7 75.5 12.4 131.2 75.8 20.7 87.6 65.9 113.0 23.2 31.9 36.1 61.8 49.3 25.6 18.5 54.4 28.7 13.1 44.9 42.5 145.2 38.5 35.1 33.5 9.4 65.9 53.7 26.9 46.4 SGCE DYT11 ENSG00000127990 "Sarcoglycan epsilon" O43556 7 94524204-94656572 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Disease variant, Dystonia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Fibroblasts: 116.6;Oligodendrocyte precursor cells: 133.2;Oligodendrocytes: 116.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "gdT-cell: 2.1;memory B-cell: 4.4;naive B-cell: 6.6" "Group enriched" "Detected in many" 4 "B-cells: 6.6;T-cells: 2.1" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA074790 Approved "Nucleoplasm,Golgi apparatus,Vesicles,Plasma membrane" Yes No 170000 "Cluster 19: B-cells - Humoral immune response" "Cluster 89: Fibroblasts - ECM organization" "Cluster 2: Karpas-707 - Immune response" "Cluster 50: Fibroblasts - ECM organization" "Vesicles, Plasma membrane" "Nucleoplasm, Golgi apparatus" "HPA074790: AB_2686713" "unprognostic (3.16e-3)" "unprognostic (9.06e-2)" "unprognostic (1.20e-1)" "unprognostic (1.20e-3)" "unprognostic (1.12e-1)" "prognostic unfavorable (1.61e-5)" "unprognostic (1.19e-2)" "unprognostic (2.82e-2)" "unprognostic (6.93e-2)" "unprognostic (3.37e-1)" "unprognostic (6.80e-3)" "unprognostic (9.69e-2)" "unprognostic (5.71e-2)" "prognostic unfavorable (1.35e-4)" "unprognostic (1.43e-1)" "unprognostic (2.04e-1)" "unprognostic (2.44e-2)" 43.2 63.4 19.9 9.4 21.6 0.4 36.5 22.1 31.6 45.1 20.9 51.6 8.0 43.2 27.1 13.3 40.7 27.6 38.9 19.6 21.0 19.5 14.4 30.5 16.7 23.2 20.6 92.2 21.5 10.9 30.9 52.7 22.4 18.0 12.8 16.8 21.1 31.6 8.5 8.2 19.2 41.8 21.9 25.1 23.8 18.5 20.4 12.8 23.9 19.8 7.2 35.6 34.6 26.7 13.5 42.5 39.6 61.8 63.7 110.8 7.1 51.3 92.3 40.7 60.4 24.9 78.0 12.8 70.4 86.5 83.7 9.4 60.0 21.6 49.1 2.2 32.7 1.4 36.9 28.3 44.0 4.3 0.0 95.5 31.1 64.8 79.3 104.9 30.8 0.0 0.1 93.7 43.5 42.6 0.0 0.0 32.8 8.0 29.0 19.8 51.0 25.8 78.6 13.6 26.2 20.8 0.0 52.2 65.1 44.2 17.6 0.8 0.0 131.1 45.1 11.8 81.7 50.8 67.9 14.8 51.4 0.2 74.2 0.7 0.0 0.1 2.1 0.0 0.8 4.4 0.6 1.0 0.0 6.6 0.2 0.7 0.3 1.0 0.1 0.2 0.2 0.3 19.9 21.6 22.1 31.6 19.6 21.0 23.2 20.6 22.4 21.9 20.4 26.7 39.2 70.5 33.3 66.9 6.1 5.0 18.4 16.8 1.8 18.6 9.7 44.4 18.6 30.0 28.3 20.2 4.2 90.2 1.4 0.0 5.9 42.5 1.6 4.0 17.1 18.8 1.2 0.4 85.2 4.3 26.1 116.6 1.5 6.6 2.5 37.3 58.2 11.2 6.3 20.2 68.5 0.1 12.2 2.5 7.3 3.7 75.5 1.4 51.6 15.9 0.0 31.5 0.0 133.2 116.3 2.1 0.0 58.3 2.6 5.5 0.0 14.1 13.7 30.3 85.5 68.0 60.7 17.1 13.0 0.9 4.0 82.8 2.7 44.0 0.0 2.2 SH3TC2 "CMT4C, KIAA1985" ENSG00000169247 "SH3 domain and tetratricopeptide repeats 2" Q8TF17 5 148923639-149063163 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 12.6;retina: 3.9" "Cell type enriched" "Detected in many" 10 "Oligodendrocytes: 270.4" "Cancer enhanced" "Detected in some" "melanoma: 1.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CACO-2: 2.6;HBEC3-KT: 2.2;RT4: 3.6;SK-MEL-30: 5.2;WM-115: 3.7" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA037683, HPA037684" Uncertain Approved Nucleoplasm,Cytosol No No "Cluster 70: Brain - Nervous system development" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Nucleoplasm, Cytosol" "HPA037683: AB_2675608, HPA037684: AB_10672603" "unprognostic (6.30e-2)" "unprognostic (4.07e-2)" "unprognostic (4.22e-2)" "unprognostic (5.52e-2)" "unprognostic (1.70e-1)" "unprognostic (1.92e-2)" "unprognostic (2.49e-1)" "unprognostic (2.17e-4)" "unprognostic (2.18e-2)" "unprognostic (4.53e-1)" "unprognostic (6.21e-3)" "unprognostic (2.20e-1)" "unprognostic (2.21e-1)" "unprognostic (6.48e-2)" "unprognostic (1.84e-1)" "unprognostic (6.62e-2)" "unprognostic (1.40e-1)" 0.1 0.0 4.7 0.0 8.0 0.1 0.1 5.1 5.0 0.1 0.4 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.3 3.6 5.1 0.0 0.0 0.0 0.0 7.1 6.9 0.0 0.0 0.0 0.0 0.4 7.3 0.0 0.0 3.9 0.1 0.1 0.2 0.1 0.0 0.0 5.8 0.0 0.0 1.5 7.1 0.0 0.0 0.1 0.0 0.1 0.0 12.6 1.8 0.1 0.0 0.0 0.0 0.0 0.0 0.6 0.4 0.3 0.1 2.6 1.5 0.0 1.8 0.1 0.6 1.9 0.0 2.2 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.4 0.2 0.0 0.0 0.0 0.7 0.2 0.0 0.0 0.0 1.1 1.6 0.0 1.3 0.0 0.7 3.6 0.0 0.0 0.0 0.0 5.2 0.1 0.0 0.0 0.2 0.1 0.3 0.0 1.0 0.0 0.0 0.0 0.0 0.4 3.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.7 8.0 5.1 5.0 3.6 5.1 7.1 6.9 7.3 5.8 7.1 12.6 1.9 3.2 3.7 0.3 0.1 0.9 0.8 1.0 0.0 1.4 0.7 0.4 1.7 1.5 3.8 0.0 4.2 0.8 0.0 0.6 0.0 0.6 6.4 0.3 0.1 2.8 0.0 0.0 0.4 0.2 0.4 0.5 0.0 0.5 2.5 0.1 1.4 0.3 0.4 0.0 0.4 0.0 2.0 1.8 0.7 2.3 0.3 2.2 0.0 4.7 0.1 2.3 0.0 0.0 270.4 1.6 0.0 0.0 0.1 1.2 0.0 0.1 4.1 25.4 0.0 0.3 0.4 2.3 0.9 1.0 0.9 11.9 0.3 0.1 0.2 8.8 SIGMAR1 "OPRS1, SR-BP1" ENSG00000147955 "Sigma non-opioid intracellular receptor 1" Q99720 9 34634722-34637844 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Lipid transport, Transport" Receptor "Amyotrophic lateral sclerosis, Disease variant, FDA approved drug targets, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 187.6" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 98.7;Hepatocytes: 97.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013470, HPA018002, HPA024071" Enhanced NA NA "Cluster 35: T-regs - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 30: Epithelial cell lines - Translation" "Cluster 33: Fibroblasts - ECM organization" "CAB013470: AB_2533521, HPA018002: AB_1854802, HPA024071: AB_1854803" "unprognostic (1.39e-1)" "unprognostic (2.64e-1)" "unprognostic (1.56e-1)" "unprognostic (1.95e-1)" "unprognostic (8.06e-2)" "unprognostic (3.71e-2)" "unprognostic (4.89e-2)" "unprognostic (2.50e-2)" "unprognostic (2.58e-2)" "unprognostic (2.01e-3)" "unprognostic (3.88e-2)" "unprognostic (4.28e-1)" "unprognostic (2.78e-2)" "unprognostic (2.46e-1)" "unprognostic (2.39e-1)" "unprognostic (6.44e-3)" "prognostic unfavorable (3.42e-4)" 42.0 52.4 25.2 19.4 25.3 20.5 38.1 26.2 27.1 53.0 27.4 42.0 46.0 50.7 45.0 54.1 46.9 22.1 34.0 25.8 30.2 25.5 187.6 27.5 16.9 28.3 28.7 46.1 45.7 39.0 22.0 27.6 29.4 35.5 31.2 7.2 35.0 38.5 17.6 53.9 40.0 34.8 26.2 24.2 42.1 20.2 33.3 19.1 29.7 13.5 22.2 46.3 43.5 27.1 184.3 162.6 59.8 175.3 205.7 138.7 66.5 127.1 91.2 115.8 105.9 97.6 76.8 87.8 71.9 151.7 69.8 108.8 94.5 151.3 57.8 144.7 175.6 78.0 225.0 112.7 131.7 145.0 67.6 142.9 163.0 131.2 197.7 59.4 90.2 114.5 30.1 156.2 139.7 1.8 88.2 215.2 68.8 101.5 184.4 101.4 59.6 258.3 111.0 36.5 57.6 65.5 123.3 89.5 70.0 32.0 106.9 98.7 68.5 90.0 69.9 96.4 19.2 43.2 71.6 2.5 97.2 123.9 191.8 24.3 39.5 24.2 43.0 39.3 46.2 26.5 62.5 51.3 48.9 21.1 51.7 43.6 10.7 28.7 42.5 35.1 65.5 43.5 25.2 25.3 26.2 27.1 25.8 30.2 28.3 28.7 29.4 26.2 33.3 27.1 11.0 3.2 13.6 6.8 12.3 18.4 16.8 24.6 14.2 10.1 26.8 18.9 9.2 15.7 12.1 7.3 0.0 44.8 10.7 33.0 0.0 33.0 0.9 7.0 23.7 14.4 10.3 23.5 5.6 33.5 98.7 29.2 18.3 10.1 7.0 19.4 13.9 97.5 38.8 5.0 6.4 28.2 12.2 10.5 7.8 1.8 27.4 10.8 19.6 5.6 9.5 13.8 14.4 5.0 4.4 32.1 31.5 25.6 22.4 25.9 58.4 13.7 6.8 7.7 19.7 12.1 23.9 6.0 10.3 40.0 21.5 36.5 13.6 26.2 47.3 16.1 SIK1 "msk, SNF1LK" ENSG00000142178 "Salt inducible kinase 1" P57059 21 43414483-43427131 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Biological rhythms, Cell cycle, Differentiation" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Epilepsy, Tumor suppressor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skin 1: 88.0" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 302.0;Basal respiratory cells: 123.5;Langerhans cells: 141.9;Suprabasal keratinocytes: 422.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HBEC3-KT: 35.3;HeLa: 63.1;hTCEpi: 45.4;LHCN-M2: 45.5;U-266/84: 37.7" "Low region specificity" "Detected in all" "CAB023801, HPA038211, HPA078064" Approved Approved Nucleoplasm,Vesicles NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 61: Skin - Cornification" "Cluster 20: HeLa - Mitochondria" "Cluster 28: Keratinocytes - Keratinization" Nucleoplasm Vesicles "CAB023801: , HPA038211: AB_2675894, HPA078064: " "unprognostic (4.06e-2)" "unprognostic (9.38e-2)" "unprognostic (3.31e-3)" "unprognostic (3.00e-1)" "unprognostic (5.02e-2)" "unprognostic (7.97e-3)" "unprognostic (1.51e-1)" "unprognostic (7.30e-3)" "unprognostic (2.35e-3)" "unprognostic (4.97e-2)" "unprognostic (1.89e-2)" "unprognostic (1.30e-1)" "unprognostic (3.89e-1)" "unprognostic (9.94e-3)" "unprognostic (3.88e-2)" "unprognostic (2.89e-1)" "unprognostic (1.82e-1)" 24.5 8.3 0.7 6.2 0.4 10.5 19.5 0.5 1.8 17.5 0.8 7.0 0.4 4.4 0.0 18.5 18.6 15.1 16.0 0.3 1.1 5.1 20.9 12.7 4.3 1.0 1.0 26.9 11.8 5.9 12.5 12.5 0.8 9.2 0.7 8.5 12.1 13.3 13.0 88.0 5.4 5.3 0.0 7.2 12.2 3.0 0.7 11.0 6.2 1.3 4.6 16.9 14.4 0.5 1.2 3.4 4.3 0.1 0.3 1.6 1.7 2.0 0.7 3.5 2.7 5.1 0.1 5.4 1.5 0.4 19.8 23.6 3.5 35.3 2.0 0.3 1.1 1.6 63.1 2.0 4.8 1.7 0.2 2.1 45.4 0.9 10.7 20.7 0.7 0.1 0.2 0.2 45.5 0.3 0.9 3.9 1.9 0.0 3.4 0.1 0.8 5.7 4.0 13.3 0.1 0.0 24.2 4.0 0.8 0.7 2.3 0.6 8.1 0.9 4.2 0.4 0.1 9.5 37.7 1.0 10.0 4.6 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.7 0.4 0.5 1.8 0.3 1.1 1.0 1.0 0.8 0.0 0.7 0.5 23.7 28.9 77.3 0.0 18.4 302.0 0.8 123.5 26.7 0.3 8.6 6.3 11.7 7.2 68.4 12.9 0.0 0.8 13.4 16.4 0.0 3.2 0.0 23.2 4.8 18.4 27.6 0.0 0.0 2.1 1.3 11.1 15.3 29.1 19.6 2.3 4.2 7.7 1.7 0.0 0.0 16.5 85.5 3.8 141.9 0.1 0.0 10.1 96.0 0.0 1.6 1.3 0.0 0.0 0.0 7.3 24.3 0.0 36.3 0.5 23.8 0.2 50.7 0.2 0.0 2.4 27.4 0.1 0.4 35.1 422.7 2.5 16.4 0.8 20.3 1.2 SIL1 "BAP, MSS, ULG5" ENSG00000120725 "SIL1 nucleotide exchange factor" Q9H173 5 138946724-139293557 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Protein transport, Translocation, Transport" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 195.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011949 Enhanced "Intracellular and membrane" NA NA 710000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 30: Epithelial cell lines - Translation" "Cluster 55: Plasma cells - Humoral immune response" "HPA011949: AB_1856875" "unprognostic (1.06e-1)" "unprognostic (9.01e-2)" "unprognostic (2.04e-1)" "prognostic favorable (4.34e-4)" "prognostic unfavorable (4.27e-4)" "unprognostic (9.12e-3)" "unprognostic (3.60e-1)" "unprognostic (2.45e-1)" "unprognostic (1.33e-1)" "unprognostic (6.91e-2)" "unprognostic (2.31e-2)" "unprognostic (9.46e-2)" "unprognostic (3.21e-3)" "unprognostic (1.59e-1)" "unprognostic (1.65e-1)" "unprognostic (6.79e-2)" "unprognostic (1.22e-2)" 26.4 46.4 9.0 19.7 10.6 24.1 21.6 8.5 11.8 21.7 17.9 20.0 24.6 21.7 32.5 16.5 19.2 23.2 29.5 9.2 9.3 20.9 54.9 22.6 14.1 10.6 9.9 19.1 67.7 33.7 28.5 28.7 10.5 23.9 12.8 5.7 36.7 25.8 41.4 23.2 16.4 17.2 8.2 17.3 29.5 49.8 11.3 9.0 36.2 18.0 10.0 20.6 16.2 10.3 33.7 34.9 11.3 56.2 84.0 48.3 65.0 54.0 58.2 26.6 57.3 36.9 78.9 12.4 89.7 74.2 32.2 29.8 12.0 76.0 15.8 33.7 20.7 16.4 23.9 40.9 67.2 4.9 72.6 60.7 73.1 46.4 79.0 42.7 40.5 15.4 8.7 131.3 32.2 52.1 12.4 15.1 2.4 38.6 4.2 8.9 7.8 92.7 38.9 17.7 19.5 13.0 46.3 44.3 74.5 24.8 38.4 30.6 30.6 46.8 10.9 17.9 23.6 56.3 31.6 8.2 34.3 38.1 39.9 18.1 47.7 19.4 17.4 52.4 10.9 20.1 12.1 16.8 51.3 14.7 12.1 15.1 5.7 22.1 42.3 37.3 11.7 27.1 9.0 10.6 8.5 11.8 9.2 9.3 10.6 9.9 10.5 8.2 11.3 10.3 22.5 19.2 47.0 51.6 32.5 22.0 33.4 61.6 15.4 9.0 33.8 21.6 30.3 38.6 48.1 42.3 37.5 121.2 19.0 41.5 11.7 61.8 109.1 25.5 37.0 21.9 33.5 7.6 75.7 81.7 104.2 46.3 38.7 32.1 60.3 29.2 29.3 143.8 70.3 25.2 73.7 64.3 52.9 33.9 21.0 195.7 28.6 36.7 48.0 49.6 113.8 15.2 17.5 66.4 57.6 46.2 34.9 22.2 114.5 32.1 51.1 46.5 51.6 26.6 19.7 21.4 27.7 96.9 61.8 13.0 23.9 153.6 16.9 60.3 43.0 30.1 SIPA1L3 "KIAA0545, SPAR3" ENSG00000105738 "Signal induced proliferation associated 1 like 3" O60292 19 37907208-38208369 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "GTPase activation" Cataract "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 28.9" "Cell type enhanced" "Detected in many" "Distal enterocytes: 93.7;Inhibitory neurons: 87.3;Oligodendrocyte precursor cells: 99.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "A549: 59.6" "Low region specificity" "Detected in all" "HPA042072, HPA045480, HPA074988" Uncertain Supported "Nucleoplasm,Golgi apparatus,Plasma membrane" NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 10: Brain - Neuronal signaling" "Cluster 18: U-2197 - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane" "Nucleoplasm, Golgi apparatus" "HPA042072: AB_2677832, HPA045480: AB_2679342, HPA074988: " "unprognostic (4.24e-2)" "unprognostic (1.23e-1)" "unprognostic (1.86e-1)" "unprognostic (5.56e-2)" "unprognostic (9.99e-2)" "unprognostic (1.22e-2)" "unprognostic (1.31e-2)" "unprognostic (5.48e-2)" "unprognostic (3.11e-1)" "unprognostic (6.05e-2)" "unprognostic (3.15e-1)" "unprognostic (5.43e-2)" "unprognostic (9.26e-3)" "unprognostic (6.45e-2)" "unprognostic (4.94e-2)" "unprognostic (5.36e-2)" "unprognostic (1.96e-2)" 2.2 3.0 6.0 6.6 3.0 2.9 5.1 10.4 16.2 4.8 2.6 10.6 18.4 3.3 1.3 4.9 4.8 3.9 6.2 28.9 2.0 6.4 3.4 5.7 6.8 4.2 4.1 2.9 9.7 3.3 3.2 1.4 3.5 5.3 7.0 5.0 8.4 3.5 6.5 11.1 18.1 1.8 1.6 7.3 9.1 4.3 5.6 3.8 10.0 7.3 5.5 4.3 3.6 5.5 34.4 59.6 7.3 9.3 4.3 4.3 4.9 14.5 12.2 9.4 8.8 20.6 19.5 19.5 12.2 12.4 7.9 7.6 6.7 27.1 10.4 6.7 3.3 5.3 5.5 6.5 8.3 3.7 5.5 3.3 14.1 17.5 37.3 13.9 10.8 5.6 3.9 4.1 16.6 10.6 5.0 5.1 6.0 27.2 15.8 10.8 5.9 2.9 20.7 29.1 17.3 9.3 16.0 27.1 2.2 3.9 18.0 3.5 23.2 15.6 5.5 48.4 22.6 5.4 10.0 6.6 20.1 4.9 20.6 0.1 0.1 0.4 0.1 0.2 0.0 1.1 0.1 0.2 0.1 1.5 0.1 0.5 0.1 0.3 1.5 0.3 0.1 0.1 6.0 3.0 10.4 16.2 28.9 2.0 4.2 4.1 3.5 1.6 5.6 5.5 4.8 6.4 10.1 41.4 24.5 12.0 5.2 10.4 6.2 21.9 22.6 12.1 5.2 22.8 10.8 23.9 14.6 2.1 9.3 93.7 3.9 7.2 4.5 19.8 4.8 5.4 25.2 10.8 61.1 15.3 1.4 3.7 40.2 16.5 2.5 4.8 6.4 23.5 3.5 33.7 87.3 46.3 20.3 5.1 13.9 9.2 2.1 8.3 5.4 50.6 7.1 3.0 5.2 99.5 58.7 13.4 38.7 1.9 12.8 6.6 50.0 21.1 19.1 5.7 6.6 4.5 3.6 1.7 5.1 8.9 16.1 0.8 5.1 1.7 30.4 5.6 SIX1 DFNA23 ENSG00000126778 "SIX homeobox 1" Q15475 14 60643421-60658259 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Apoptosis, Transcription, Transcription regulation" "Activator, Developmental protein, DNA-binding, Repressor" "Cancer-related genes, Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "parathyroid gland: 47.8;salivary gland: 51.1;skeletal muscle: 119.4;tongue: 46.3" "Cell type enhanced" "Detected in some" "Basal prostatic cells: 30.7;Basal respiratory cells: 30.8;Club cells: 33.9;Ionocytes: 30.5;Prostatic glandular cells: 27.4;Respiratory ciliated cells: 67.1;Skeletal myocytes: 77.3;Spermatogonia: 25.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "hTERT-RPE1: 36.3;LHCN-M2: 142.2;RH-30: 71.9" "Not detected" "Not detected" "Low region specificity" "Detected in single" "HPA001893, CAB058690" Enhanced Supported Nucleoplasm,Nucleoli No No "Cluster 13: Striated muscle - Muscle contraction" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 50: Fibroblasts - ECM organization" Nucleoplasm Nucleoli "CAB058690: AB_2665581, HPA001893: AB_1079991" "unprognostic (3.62e-1)" "unprognostic (5.44e-2)" "unprognostic (5.09e-2)" "prognostic unfavorable (8.92e-6)" "unprognostic (1.33e-2)" "unprognostic (1.44e-2)" "unprognostic (2.04e-3)" "prognostic favorable (3.94e-4)" "unprognostic (1.40e-1)" "unprognostic (9.15e-2)" "unprognostic (6.45e-2)" "unprognostic (1.89e-1)" "unprognostic (3.06e-8)" "unprognostic (8.61e-2)" "unprognostic (2.13e-1)" "unprognostic (1.94e-1)" "unprognostic (3.86e-1)" 5.5 0.4 0.3 0.0 0.5 0.0 1.9 0.5 1.2 15.2 1.0 0.0 0.0 0.0 0.4 1.1 0.8 0.5 0.0 0.3 0.3 0.0 0.0 1.5 0.5 0.3 0.4 0.2 0.3 47.8 19.8 0.0 0.4 13.2 0.0 0.0 51.1 0.2 119.4 0.3 0.0 0.0 0.3 0.0 0.4 1.7 0.5 9.7 1.9 46.3 0.2 1.6 0.8 0.4 15.2 3.5 0.6 28.1 17.0 20.6 0.4 4.1 10.6 4.9 4.0 0.0 8.2 0.0 2.2 0.6 2.1 4.4 10.3 6.4 2.1 0.0 17.1 2.0 1.9 6.8 0.0 0.0 0.2 15.6 4.9 2.3 0.7 36.3 0.3 1.6 5.8 0.0 142.2 2.8 0.0 0.5 0.0 0.0 8.9 0.0 71.9 0.0 5.9 16.3 2.5 0.3 5.0 0.3 6.1 0.5 3.3 0.4 13.9 6.7 5.4 7.9 6.5 0.5 0.1 0.0 1.5 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.5 0.5 1.2 0.3 0.3 0.3 0.4 0.4 0.3 0.5 0.4 0.8 3.2 1.5 0.0 0.0 0.1 30.7 30.8 0.6 0.0 1.0 0.8 0.9 0.0 33.9 1.8 0.0 0.2 0.0 0.1 1.9 0.0 0.2 1.1 0.1 1.6 0.0 0.0 0.0 0.8 0.4 5.7 0.5 1.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 30.5 0.0 0.0 0.6 0.0 0.3 0.0 1.9 0.0 0.8 0.0 1.0 0.1 0.2 0.0 1.2 0.0 27.4 0.0 0.1 67.1 0.2 0.0 77.3 5.1 0.0 25.0 0.1 0.1 0.3 0.1 0.1 0.0 18.3 SLC12A5 "KCC2, KIAA1176" ENSG00000124140 "Solute carrier family 12 member 5" Q9H2X9 20 46021690-46060150 "Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Ion transport, Potassium transport, Symport, Transport" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 145.8;retina: 117.4" "Cell type enhanced" "Detected in many" "Bipolar cells: 244.0;Cone photoreceptor cells: 383.7;Excitatory neurons: 92.7;Inhibitory neurons: 91.3;Rod photoreceptor cells: 170.9" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "naive CD4 T-cell: 2.4" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "Hep G2: 24.9;NB-4: 50.8;SK-BR-3: 24.8;U-2 OS: 28.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA072058 Enhanced NA NA "Cluster 35: T-regs - Unknown function" "Cluster 58: Brain - Synaptic function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 9: Photoreceptor cells - Phototransduction" "HPA072058: AB_2686485" "unprognostic (2.01e-1)" "unprognostic (3.58e-1)" "unprognostic (7.55e-2)" "unprognostic (9.44e-4)" "prognostic unfavorable (5.60e-4)" "unprognostic (2.48e-1)" "unprognostic (5.16e-3)" "unprognostic (3.61e-1)" "unprognostic (2.49e-1)" "unprognostic (6.63e-2)" "unprognostic (3.72e-3)" "unprognostic (5.61e-4)" "unprognostic (8.78e-4)" "unprognostic (3.25e-2)" "unprognostic (9.22e-2)" "unprognostic (1.99e-1)" "unprognostic (2.34e-2)" 1.5 26.7 101.3 0.9 103.5 0.4 1.0 97.6 145.8 0.9 14.9 1.4 1.0 0.7 0.9 0.4 0.5 0.7 5.1 107.0 96.6 1.1 1.2 2.5 2.2 76.3 80.5 2.3 2.2 1.8 41.5 2.0 69.9 1.0 0.9 117.4 0.7 0.5 0.4 0.6 1.6 0.4 69.3 3.0 1.9 7.8 86.7 2.9 0.7 0.2 1.4 0.6 0.7 88.4 0.0 15.2 6.6 4.9 0.6 0.0 1.5 0.6 0.0 0.0 0.5 2.0 0.0 5.8 22.5 0.4 5.9 1.4 4.3 2.3 0.4 3.7 5.7 4.9 3.0 24.9 2.5 0.0 6.5 0.8 0.0 0.0 0.3 10.0 1.4 5.4 9.3 0.0 0.0 23.1 3.5 50.8 2.4 2.1 7.7 5.8 4.2 1.3 2.3 0.0 8.1 11.5 2.9 24.8 7.9 6.0 9.0 14.4 2.3 2.7 28.0 0.2 1.1 0.0 4.2 8.2 5.9 5.9 0.2 0.0 0.6 0.0 1.1 0.4 0.5 0.4 0.1 0.1 0.1 0.5 2.4 1.3 0.0 0.4 0.1 0.0 1.9 0.3 101.3 103.5 97.6 145.8 107.0 96.6 76.3 80.5 69.9 69.3 86.7 88.4 2.2 0.0 0.0 10.4 0.4 0.5 0.0 0.0 0.0 244.0 0.8 2.2 1.2 0.0 0.0 0.0 383.7 1.6 0.9 0.0 1.9 0.1 1.9 0.4 0.1 2.9 19.9 4.4 92.7 0.2 2.5 0.4 1.5 0.6 0.0 14.4 4.6 1.3 19.8 13.5 91.3 0.7 0.0 2.6 5.3 6.1 0.0 3.4 5.4 10.3 0.6 28.2 0.0 3.5 6.3 0.4 0.0 0.0 0.8 0.2 0.0 0.3 0.0 170.9 0.0 0.0 2.2 4.2 7.7 0.1 0.6 1.6 1.0 8.5 0.3 0.1 SLC12A6 "ACCPN, KCC3" ENSG00000140199 "Solute carrier family 12 member 6" Q9UHW9 15 34229784-34338060 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Ion transport, Potassium transport, Symport, Transport" Neuropathy "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 85.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 6 "basophil: 15.2;neutrophil: 23.4" "Lineage enriched" "Detected in many" 7 "granulocytes: 23.4" "Cell line enhanced" "Detected in many" "HaCaT: 44.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA034563 Uncertain Approved Vesicles,Cytosol NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 34: Non-specific - Transcription" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 57: B-cells - Immune response" "Vesicles, Cytosol" "HPA034563: AB_10603887" "unprognostic (3.53e-1)" "unprognostic (4.82e-2)" "unprognostic (4.26e-2)" "unprognostic (3.60e-1)" "unprognostic (3.55e-2)" "unprognostic (3.41e-2)" "unprognostic (1.36e-1)" "unprognostic (2.88e-1)" "unprognostic (2.07e-1)" "unprognostic (1.68e-1)" "unprognostic (6.58e-2)" "unprognostic (1.83e-1)" "prognostic favorable (3.33e-6)" "unprognostic (2.39e-1)" "unprognostic (1.61e-1)" "unprognostic (3.87e-2)" "unprognostic (1.41e-1)" 6.4 4.0 5.9 11.5 7.4 26.8 5.5 7.2 7.9 11.9 2.5 5.5 7.3 5.2 7.0 18.8 4.6 5.2 7.3 6.5 7.3 15.9 3.9 9.1 10.1 8.9 7.3 4.2 3.5 3.1 5.6 4.3 9.3 3.5 6.1 31.1 6.4 3.8 10.6 7.6 9.1 4.9 6.6 12.9 6.7 25.9 7.7 15.5 9.0 10.9 11.6 8.3 17.6 8.4 4.4 5.2 3.1 4.7 10.0 11.4 2.4 5.9 15.1 4.9 7.1 3.1 7.2 3.1 5.9 7.2 4.3 44.0 7.9 5.3 5.8 1.2 5.1 24.6 14.0 7.0 6.4 14.5 24.6 6.9 9.1 14.1 29.1 10.9 14.9 6.8 5.4 6.8 6.7 1.6 1.6 11.0 2.4 3.8 5.7 7.1 5.5 3.3 5.5 11.2 7.2 5.0 7.1 0.2 1.5 7.1 2.8 4.8 9.4 5.9 4.2 21.0 1.4 6.4 6.8 1.9 6.6 10.5 2.2 15.2 1.4 2.6 0.6 1.8 0.4 1.4 0.9 0.9 0.9 2.4 1.6 1.4 23.4 0.7 0.8 1.0 3.2 1.0 5.9 7.4 7.2 7.9 6.5 7.3 8.9 7.3 9.3 6.6 7.7 8.4 16.4 22.4 21.0 30.0 32.0 1.1 4.5 1.5 7.4 15.3 5.2 4.3 8.7 5.7 4.2 5.5 85.5 3.2 11.5 8.6 0.0 5.6 15.6 9.8 7.4 17.7 6.7 35.9 47.7 4.7 1.6 7.0 17.9 22.4 5.1 8.4 16.1 7.5 13.2 8.4 52.0 7.0 2.0 37.1 3.8 8.3 8.1 25.6 0.0 50.6 34.5 8.7 15.5 40.7 58.4 13.1 9.7 8.6 29.9 6.5 18.3 16.4 4.2 56.6 19.7 7.0 4.0 39.9 21.2 14.8 0.9 1.1 18.0 4.1 7.4 43.6 SLC13A5 "INDY, NACT" ENSG00000141485 "Solute carrier family 13 member 5" Q86YT5 17 6684719-6713377 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Ion transport, Sodium transport, Symport, Transport" "Amelogenesis imperfecta, Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 11 "liver: 414.0" "Cell type enriched" "Detected in some" 15 "Hepatocytes: 381.0" "Cancer enriched" "Detected in some" 15 "liver cancer: 27.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 79 "Hep G2: 58.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044343 Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 62: Liver - Hemostasis" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 15: Hepatocytes - Hemostasis" "Plasma membrane" "Nucleoplasm, Cytosol" "HPA044343: AB_10961771" "unprognostic (8.46e-3)" "unprognostic (3.89e-2)" "unprognostic (3.24e-2)" "unprognostic (1.75e-2)" "unprognostic (7.33e-2)" "unprognostic (1.07e-1)" "unprognostic (6.79e-2)" "unprognostic (8.79e-3)" "unprognostic (1.32e-1)" "unprognostic (3.23e-1)" "unprognostic (1.26e-3)" "unprognostic (1.30e-3)" "unprognostic (3.78e-11)" "unprognostic (2.42e-2)" "unprognostic (2.46e-1)" "unprognostic (2.05e-2)" "unprognostic (2.04e-1)" 0.3 2.7 4.8 0.0 7.0 0.0 0.3 4.8 8.0 0.3 2.7 0.0 0.0 0.3 0.0 1.1 2.1 0.0 0.1 5.3 7.9 0.7 414.0 0.0 0.2 6.8 6.1 0.6 0.3 0.0 0.8 0.0 5.4 0.0 0.0 1.7 38.0 0.0 0.0 0.1 0.0 0.0 4.8 3.3 0.0 2.3 8.4 0.0 0.0 0.0 0.0 0.0 0.2 3.9 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 58.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.7 0.4 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.8 7.0 4.8 8.0 5.3 7.9 6.8 6.1 5.4 4.8 8.4 3.9 0.4 0.0 0.0 24.8 4.8 0.5 0.6 0.6 1.2 0.6 0.1 0.1 0.9 7.2 0.2 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.2 0.1 0.1 1.9 0.0 24.0 0.3 0.5 0.1 0.4 0.0 0.1 0.0 0.9 16.8 381.0 0.0 0.0 0.2 0.0 0.0 23.2 1.1 0.4 0.6 0.3 0.0 1.9 0.0 7.0 0.0 1.5 0.1 16.9 0.0 0.0 0.0 0.3 0.0 0.0 0.1 1.6 0.0 0.5 0.5 2.4 2.8 1.2 0.4 0.1 1.0 7.8 0.0 0.3 SLC16A12 MCT12 ENSG00000152779 "Solute carrier family 16 member 12" Q6ZSM3 10 89430299-89556641 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Symport, Transport" Cataract "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "choroid plexus: 92.2;epididymis: 51.8;kidney: 85.2;pancreas: 25.3" "Cell type enhanced" "Detected in many" "Enteroendocrine cells: 18.1;Leydig cells: 27.1;Peritubular cells: 26.7;Proximal tubular cells: 69.2" "Cancer enriched" "Detected in many" 10 "renal cancer: 18.0" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "ASC TERT1: 23.0;HSkMC: 8.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA037587 Approved Mitochondria NA NA "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "HPA037587: AB_2732475" "unprognostic (5.38e-2)" "unprognostic (1.29e-1)" "unprognostic (2.79e-2)" "unprognostic (2.28e-2)" "unprognostic (3.51e-1)" "unprognostic (5.35e-2)" "unprognostic (2.45e-1)" "unprognostic (1.32e-1)" "unprognostic (1.78e-2)" "unprognostic (2.42e-1)" "unprognostic (9.60e-2)" "unprognostic (2.31e-1)" "prognostic favorable (4.50e-12)" "unprognostic (3.84e-2)" "unprognostic (7.91e-2)" "unprognostic (8.29e-2)" "unprognostic (1.84e-3)" 1.8 2.5 0.8 0.1 1.1 0.0 1.9 1.0 2.7 9.2 92.2 0.8 0.1 1.4 51.8 0.3 4.1 0.1 4.9 2.9 0.3 85.2 2.0 2.5 0.1 0.5 1.6 1.3 25.3 0.1 3.4 11.6 0.6 0.6 0.2 0.0 0.4 14.1 1.6 0.5 0.3 0.3 1.2 0.0 1.0 3.3 1.0 0.4 6.2 2.5 0.0 0.4 0.7 0.6 0.2 0.0 0.0 0.0 3.0 23.0 0.2 0.0 0.0 0.1 0.3 0.1 0.0 0.0 0.1 0.0 1.2 0.2 0.0 0.3 0.5 0.0 0.0 0.0 0.5 0.0 3.7 0.0 0.0 8.2 0.2 1.2 1.5 2.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.8 0.0 2.8 0.0 0.1 0.1 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.3 0.7 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.8 1.1 1.0 2.7 2.9 0.3 0.5 1.6 0.6 1.2 1.0 0.6 0.8 3.2 3.9 3.3 0.6 0.0 2.2 0.1 0.0 0.1 4.6 0.1 3.3 1.5 2.9 14.7 0.0 16.4 0.1 0.0 15.6 0.0 8.3 11.5 0.8 1.3 18.1 0.0 0.3 4.1 1.1 2.2 0.0 1.0 1.3 0.0 0.4 2.2 1.2 3.3 0.4 0.2 0.0 0.0 0.9 4.8 27.1 1.0 0.0 11.2 0.1 0.0 0.0 0.0 0.4 2.1 0.1 26.7 0.0 0.7 0.0 69.2 6.2 0.6 13.1 3.4 7.8 0.2 0.5 0.0 0.3 9.0 0.9 0.1 0.0 1.8 SLC17A8 "DFNA25, VGLUT3" ENSG00000179520 "Solute carrier family 17 member 8" Q8NDX2 12 100357074-100422055 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Hearing, Ion transport, Neurotransmitter transport, Sodium transport, Symport, Transport" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "brain: 11.3;intestine: 5.2" "Group enriched" "Detected in some" 4 "Endometrial ciliated cells: 13.3;Proximal enterocytes: 43.1" "Cancer enhanced" "Detected in single" "glioma: 0.5" "Group enriched" "Detected in many" 5 "basal ganglia: 11.3;midbrain: 8.3;pons: 6.5" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in some" CAB079058 Supported NA NA "Cluster 45: Intestine - Brush border" "Cluster 45: Enterocytes - Digestion" "CAB079058: " "unprognostic (4.52e-3)" "unprognostic (2.18e-1)" "unprognostic (8.56e-2)" "unprognostic (1.32e-3)" "unprognostic (3.65e-1)" "unprognostic (7.67e-2)" "unprognostic (1.25e-1)" "unprognostic (1.71e-2)" "unprognostic (8.89e-2)" "unprognostic (3.55e-1)" 0.0 0.0 0.4 0.0 11.3 0.0 0.0 0.0 1.6 0.0 0.7 0.4 0.7 0.1 0.0 0.0 0.3 0.0 0.0 0.4 1.3 0.0 0.5 0.0 0.0 0.4 8.3 0.0 0.0 0.0 0.0 0.3 6.5 0.0 0.3 1.2 0.0 0.0 0.0 0.0 5.2 0.0 0.2 0.0 0.0 0.1 1.6 1.4 0.0 0.0 0.0 0.4 0.0 0.2 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 11.3 0.0 1.6 0.4 1.3 0.4 8.3 6.5 0.2 1.6 0.2 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 13.3 0.1 0.1 0.0 0.0 0.4 0.0 3.9 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 6.6 1.1 0.0 3.2 0.0 0.0 0.3 0.0 0.0 1.0 0.0 0.0 0.0 1.5 0.2 0.0 1.7 0.0 0.0 0.0 43.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.1 0.0 SLC18A3 VACHT ENSG00000187714 "Solute carrier family 18 member A3" Q16572 10 49610310-49612720 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Neurotransmitter transport, Transport" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 21 "brain: 25.6" "Cell type enriched" "Detected in some" 4 "Fibroblasts: 7.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "SH-SY5Y: 7.2" "Low region specificity" "Detected in many" "Region enriched" "Detected in many" 5 "spinal cord: 78.1" CAB079011 Supported NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 33: Fibroblasts - ECM organization" "CAB079011: " "unprognostic (2.14e-4)" "unprognostic (1.55e-1)" "unprognostic (1.01e-1)" "unprognostic (9.39e-2)" "unprognostic (4.55e-2)" "unprognostic (3.00e-1)" "unprognostic (5.85e-3)" "unprognostic (7.56e-2)" "unprognostic (1.16e-1)" 0.0 0.0 0.7 0.3 2.0 0.0 0.0 0.0 19.7 0.0 0.0 1.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 4.9 0.0 0.0 0.0 0.0 18.9 8.0 0.0 0.0 0.0 1.2 0.4 25.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.2 3.6 0.0 0.7 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.5 6.6 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 7.2 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 2.0 0.0 19.7 0.1 4.9 18.9 8.0 25.6 3.6 0.7 6.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4 7.4 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.0 0.0 1.5 0.0 0.0 0.0 0.0 SLC19A2 "THTR1, TRMA" ENSG00000117479 "Solute carrier family 19 member 2" O60779 1 169463909-169485944 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" Transport "Deafness, Diabetes mellitus, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 124.1;tongue: 84.9" "Cell type enhanced" "Detected in many" "Skeletal myocytes: 84.5;Syncytiotrophoblasts: 156.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006119, HPA016599" Uncertain Approved Cytosol NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 50: Fibroblasts - ECM organization" Cytosol "HPA006119: AB_1079996, HPA016599: AB_1857005" "prognostic favorable (8.41e-4)" "unprognostic (8.82e-2)" "unprognostic (1.90e-1)" "unprognostic (3.29e-3)" "prognostic favorable (2.90e-4)" "unprognostic (4.45e-2)" "unprognostic (9.69e-2)" "unprognostic (1.45e-1)" "unprognostic (2.86e-2)" "unprognostic (1.60e-1)" "unprognostic (1.76e-1)" "unprognostic (1.65e-1)" "prognostic favorable (2.70e-5)" "unprognostic (1.08e-1)" "unprognostic (2.09e-1)" "unprognostic (3.60e-2)" "unprognostic (2.14e-2)" 42.2 17.8 3.0 8.3 3.1 8.7 20.9 5.1 4.2 10.5 9.3 11.8 3.5 8.6 6.1 11.3 21.3 25.8 31.2 4.0 3.6 13.0 37.1 19.5 2.6 4.9 3.7 20.5 22.2 24.8 19.0 18.1 4.0 10.5 4.3 7.5 12.5 3.8 124.1 16.5 11.4 6.1 3.7 2.8 19.2 7.8 4.2 4.1 15.7 84.9 2.8 18.1 12.9 3.5 7.4 5.1 11.4 9.0 34.4 12.7 25.0 5.8 4.3 4.6 6.5 20.9 7.6 6.5 6.4 3.9 8.5 7.7 13.9 8.5 5.1 18.8 13.0 6.2 16.7 19.3 18.7 15.8 5.9 15.0 12.2 7.4 18.8 6.4 7.0 11.3 25.3 4.1 7.9 5.0 8.2 7.1 25.8 14.1 7.7 0.0 24.6 7.5 12.2 15.5 9.9 13.3 8.0 13.6 29.2 12.8 8.5 10.1 5.8 5.5 7.7 6.9 11.4 5.6 5.6 2.1 8.1 6.0 7.4 0.0 0.6 1.1 0.3 0.2 1.1 0.4 0.4 0.7 0.7 0.4 1.0 1.0 0.4 0.9 2.0 0.2 0.3 0.2 3.0 3.1 5.1 4.2 4.0 3.6 4.9 3.7 4.0 3.7 4.2 3.5 13.6 9.6 19.3 11.8 7.3 29.6 16.5 4.4 43.9 5.3 34.1 13.6 27.7 7.2 11.4 5.5 2.1 26.9 11.3 10.6 0.0 7.4 4.3 22.6 9.7 3.7 9.0 5.2 15.6 5.3 4.5 52.7 49.5 42.7 10.2 4.1 1.1 29.8 7.0 6.7 22.8 6.4 12.2 2.9 8.8 2.7 6.8 18.3 21.4 7.5 1.0 2.5 2.1 16.1 3.3 9.6 5.4 4.9 14.0 16.5 5.6 2.0 12.7 5.1 0.0 84.5 14.2 6.7 4.1 35.2 50.4 156.4 7.5 3.1 6.7 28.9 SLC1A2 "EAAT2, GLT-1" ENSG00000110436 "Solute carrier family 1 member 2" P43004 11 35251205-35420063 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Amino-acid transport, Symport, Transport" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 8 "brain: 782.3;choroid plexus: 202.7" "Cell type enriched" "Detected in many" 7 "Astrocytes: 4607.2" "Cancer enriched" "Detected in some" 5 "glioma: 28.6" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "basophil: 1.3" "Lineage enriched" "Detected in single" 5 "granulocytes: 1.3" "Cell line enhanced" "Detected in some" "ASC TERT1: 2.1;BJ hTERT+: 2.4;fHDF/TERT166: 1.7;Hep G2: 2.9;NTERA-2: 3.1;SCLC-21H: 1.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002574, HPA009172, HPA067499" Enhanced NA NA "Cluster 17: Basophils - Unknown function" "Cluster 65: Brain - Ion transport" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 64: Astrocytes - Nervous system maintenance" "CAB002574: AB_564087, HPA009172: AB_1849764, HPA067499: " "unprognostic (8.00e-2)" "unprognostic (5.71e-3)" "unprognostic (1.39e-1)" "unprognostic (2.77e-2)" "unprognostic (1.33e-1)" "unprognostic (5.65e-3)" "unprognostic (1.39e-2)" "unprognostic (9.27e-3)" "unprognostic (1.55e-1)" "unprognostic (1.65e-2)" "unprognostic (1.79e-3)" "unprognostic (2.35e-1)" "unprognostic (8.33e-4)" "unprognostic (6.34e-2)" "unprognostic (8.06e-2)" "unprognostic (5.24e-2)" "unprognostic (3.49e-2)" 0.6 4.6 546.9 0.6 731.2 0.4 3.8 388.1 782.3 1.2 202.7 0.2 0.5 1.0 0.3 0.2 0.3 0.2 0.9 631.1 432.5 0.2 34.9 0.6 1.9 450.6 533.6 0.1 9.5 0.1 2.6 1.1 384.2 0.3 0.1 60.1 4.6 0.1 0.3 1.3 0.2 0.3 409.7 0.5 2.1 1.7 498.7 0.2 0.3 0.5 1.6 0.3 0.6 453.4 0.0 0.1 0.5 0.0 0.2 2.1 0.0 0.5 2.4 0.1 0.1 0.0 0.0 0.0 0.0 1.7 0.1 0.1 0.0 0.0 0.2 0.0 0.0 0.2 0.3 2.9 0.1 0.3 0.1 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 1.1 0.0 0.0 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.6 0.2 0.0 1.1 0.0 0.1 0.5 0.0 0.3 0.1 0.1 0.2 0.0 0.3 0.0 0.0 0.5 0.0 0.1 1.3 0.1 0.2 0.1 0.0 0.0 0.1 0.1 0.0 0.1 0.2 0.2 0.1 0.5 0.2 0.1 0.1 0.1 0.1 546.9 731.2 388.1 782.3 631.1 432.5 450.6 533.6 384.2 409.7 498.7 453.4 0.4 3.2 4.8 4607.2 0.4 2.9 0.0 0.0 0.0 109.9 8.1 2.4 3.1 0.0 0.0 0.0 148.0 25.6 0.3 0.1 0.0 0.1 96.6 1.8 11.7 1.6 0.0 0.0 83.7 3.4 1.0 3.1 1.1 1.5 0.0 0.7 0.0 6.7 3.3 6.7 81.5 0.0 0.0 0.0 3.0 97.9 0.0 0.6 1.8 194.9 31.6 10.1 0.0 634.9 12.3 0.4 0.0 0.0 0.1 0.3 0.0 0.1 0.8 161.2 0.0 0.3 1.8 0.5 1.3 0.0 1.1 269.4 0.2 0.0 0.0 0.1 SLC1A3 "EA6, EAAT1, GLAST" ENSG00000079215 "Solute carrier family 1 member 3" P43003 5 36596588-36688334 "Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Amino-acid transport, Symport, Transport" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 10 "brain: 776.8;choroid plexus: 400.6;retina: 221.1" "Cell type enhanced" "Detected in many" "Astrocytes: 1735.2;Microglial cells: 332.6;Muller glia cells: 472.6;Oligodendrocyte precursor cells: 237.7;Oligodendrocytes: 249.0" "Cancer enriched" "Detected in all" 21 "glioma: 168.1" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 9 "classical monocyte: 1.5;intermediate monocyte: 1.2;myeloid DC: 1.6" "Group enriched" "Detected in many" 16 "dendritic cells: 1.6;monocytes: 1.5" "Cell line enhanced" "Detected in many" "AF22: 50.0;CACO-2: 112.6;HaCaT: 71.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002573, HPA037467, HPA037468" Enhanced Supported Approved Nucleoli,Vesicles NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 39: CACO-2 - Unknown function" "Cluster 64: Astrocytes - Nervous system maintenance" "Nucleoli, Vesicles" "CAB002573: AB_564088, HPA037467: AB_10795027, HPA037468: AB_10671371" "unprognostic (1.23e-1)" "unprognostic (2.15e-2)" "unprognostic (2.58e-3)" "unprognostic (1.74e-2)" "unprognostic (1.02e-1)" "unprognostic (7.70e-2)" "unprognostic (3.89e-3)" "unprognostic (2.36e-1)" "unprognostic (1.24e-1)" "unprognostic (2.84e-2)" "unprognostic (4.17e-3)" "unprognostic (3.28e-1)" "unprognostic (2.46e-1)" "unprognostic (1.06e-1)" "unprognostic (4.17e-2)" "unprognostic (1.03e-1)" "unprognostic (1.31e-2)" 30.7 16.4 500.4 7.4 544.2 3.3 17.7 549.4 776.8 8.7 400.6 3.0 0.5 1.6 1.1 10.5 6.0 8.0 45.4 514.6 502.5 2.2 3.8 10.2 17.4 477.6 510.1 12.6 5.0 2.2 18.1 20.3 502.4 3.2 1.1 221.1 4.7 4.7 14.1 6.0 3.2 4.1 495.4 9.3 2.2 1.2 532.8 3.6 3.4 9.2 5.4 7.0 5.3 494.9 1.3 0.2 50.0 5.3 5.9 14.3 37.7 0.3 0.0 2.4 4.9 112.6 5.6 0.0 27.8 2.3 1.0 71.4 16.9 9.1 2.2 1.8 33.0 0.0 0.5 0.0 2.5 1.3 0.6 26.9 34.5 14.4 5.3 1.8 0.0 1.1 0.0 0.2 8.7 0.2 0.1 0.1 6.0 0.1 5.9 0.0 0.5 0.0 0.1 3.1 4.7 0.0 5.1 14.6 2.1 24.4 0.2 3.1 0.0 6.2 10.3 0.1 20.7 0.0 0.0 0.3 21.7 37.7 12.6 0.0 1.5 0.0 0.0 1.2 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 500.4 544.2 549.4 776.8 514.6 502.5 477.6 510.1 502.4 495.4 532.8 494.9 1.1 3.2 0.5 1735.2 0.7 10.7 14.3 19.0 83.1 7.1 3.7 3.4 36.0 0.0 3.1 0.0 2.1 32.9 0.1 0.0 0.0 0.8 0.7 16.3 1.2 8.9 0.0 0.8 2.6 0.0 15.9 7.8 2.0 11.7 0.0 0.2 1.1 0.5 41.2 3.3 4.7 0.0 0.0 77.6 5.9 4.1 4.4 59.6 7.2 332.6 3.3 472.6 0.0 237.7 249.0 0.3 0.0 0.0 0.7 5.2 0.0 0.0 5.3 19.1 6.6 2.6 3.1 0.3 0.3 32.7 7.1 9.2 1.0 20.7 0.0 3.6 SLC20A2 "Glvr-2, GLVR2, MLVAR, PiT-2, Ram-1" ENSG00000168575 "Solute carrier family 20 member 2" Q08357 8 42416475-42541926 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport" "Host cell receptor for virus entry, Receptor" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "choroid plexus: 130.6;skeletal muscle: 131.2" "Cell type enhanced" "Detected in all" "Basal prostatic cells: 250.2;Oligodendrocytes: 151.7;Urothelial cells: 170.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "CAPAN-2: 132.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026540 Approved NA NA "Cluster 15: NK-cells - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 22: Epithelial cell types - Mixed function" "HPA026540: AB_1855408" "prognostic unfavorable (7.67e-4)" "unprognostic (3.22e-1)" "unprognostic (3.24e-2)" "unprognostic (2.27e-2)" "unprognostic (2.12e-2)" "unprognostic (2.95e-1)" "unprognostic (2.32e-1)" "unprognostic (1.57e-1)" "unprognostic (2.95e-1)" "unprognostic (7.62e-2)" "unprognostic (2.06e-1)" "unprognostic (3.43e-2)" "prognostic favorable (1.01e-4)" "unprognostic (2.13e-1)" "unprognostic (1.27e-1)" "unprognostic (5.86e-2)" "unprognostic (4.95e-2)" 11.9 8.0 33.4 9.8 45.3 3.0 12.1 55.4 37.1 15.8 130.6 22.8 46.7 18.5 9.9 32.7 24.5 15.1 63.2 30.1 48.7 17.5 39.7 15.1 6.5 46.5 56.5 8.1 51.6 15.0 10.5 13.5 47.5 13.6 19.0 7.5 87.9 17.6 131.2 23.3 18.8 17.9 42.7 7.4 15.1 15.9 67.8 11.9 82.8 57.6 9.1 22.0 21.7 52.8 52.7 14.3 19.0 16.0 10.4 8.8 41.1 46.9 80.8 23.9 58.7 38.9 132.9 17.4 53.6 42.1 13.5 81.1 11.4 45.2 41.6 4.3 8.7 27.8 4.8 22.0 14.9 9.9 12.3 9.5 40.2 24.7 22.7 16.7 12.0 13.7 27.2 14.0 47.3 14.4 18.1 16.1 19.2 50.5 8.8 14.9 20.9 18.5 21.4 47.5 5.1 19.2 12.8 21.8 12.8 15.0 17.5 17.3 34.9 50.0 17.4 12.3 25.7 9.0 22.2 12.6 15.8 19.5 28.3 3.2 2.2 0.2 3.6 1.6 4.3 2.1 4.0 3.5 3.7 2.1 4.8 3.7 0.8 6.8 1.3 2.0 4.1 3.1 33.4 45.3 55.4 37.1 30.1 48.7 46.5 56.5 47.5 42.7 67.8 52.8 11.1 28.9 18.6 51.6 9.1 98.9 250.2 22.7 96.2 13.4 21.7 14.9 60.2 14.3 21.7 16.5 16.7 23.9 14.3 76.2 13.7 29.6 10.4 79.9 15.8 18.9 12.0 6.9 88.9 31.4 23.7 15.8 15.8 61.2 3.8 17.1 6.4 30.7 10.2 6.7 88.4 11.5 18.3 7.7 12.2 10.0 7.2 10.2 10.6 78.7 7.3 14.4 14.4 63.3 151.7 47.4 35.8 11.7 8.6 76.6 20.0 7.3 57.6 10.2 6.6 22.9 28.3 5.2 7.2 73.9 74.3 25.4 14.2 23.7 12.5 170.3 SLC24A1 "CSNB1D, HsT17412, KIAA0702, NCKX, NCKX1, RODX" ENSG00000074621 "Solute carrier family 24 member 1" O60721 15 65611366-65660995 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Antiport, Calcium transport, Ion transport, Sensory transduction, Symport, Transport, Vision" "Congenital stationary night blindness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 34 "retina: 193.5" "Cell type enriched" "Detected in many" 11 "Rod photoreceptor cells: 338.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "basophil: 2.6" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA039370 Enhanced Approved Microtubules NA NA "Cluster 6: Non-specific - Transcription" "Cluster 79: Retina - Phototransduction" "Cluster 21: OE19 - Mitochondria" "Cluster 46: Photoreceptor cells - Phototransduction" Microtubules "HPA039370: AB_10960279" "unprognostic (9.47e-2)" "unprognostic (9.97e-2)" "unprognostic (1.66e-1)" "unprognostic (3.66e-3)" "unprognostic (6.39e-3)" "unprognostic (4.64e-1)" "unprognostic (8.82e-2)" "unprognostic (1.86e-1)" "unprognostic (4.69e-2)" "unprognostic (3.94e-1)" "unprognostic (2.01e-1)" "unprognostic (9.91e-2)" "prognostic favorable (2.33e-6)" "unprognostic (8.45e-2)" "unprognostic (9.22e-2)" "unprognostic (3.04e-2)" "unprognostic (1.96e-2)" 4.0 3.0 2.4 1.9 2.2 1.8 4.9 5.7 2.7 4.8 2.5 2.6 2.2 3.8 4.7 2.4 5.1 3.8 1.6 2.1 2.1 5.1 2.9 3.1 3.3 2.3 2.3 5.4 2.9 3.8 2.7 3.6 2.3 3.2 2.4 193.5 2.6 3.1 1.0 5.1 3.0 2.9 2.3 3.9 2.5 4.1 2.1 2.4 5.1 1.3 1.8 3.0 3.2 2.5 1.5 3.0 3.2 2.9 4.7 7.9 4.0 3.7 4.2 3.7 2.4 1.4 6.5 2.1 12.4 3.7 1.3 4.1 3.9 4.2 2.1 2.2 2.8 4.6 2.5 6.8 6.8 3.1 6.0 6.7 5.9 2.1 12.3 5.1 6.4 4.8 5.0 7.0 6.0 6.4 2.0 2.8 4.1 13.5 1.2 2.0 1.0 1.4 5.6 6.0 1.5 2.1 1.0 2.8 8.0 4.4 6.0 4.2 9.3 3.7 3.7 1.4 2.6 2.8 5.5 2.4 3.9 6.4 3.1 2.6 0.4 0.7 0.4 0.4 0.5 0.4 0.4 0.4 0.3 1.0 0.3 0.4 0.6 0.8 0.2 0.8 0.1 0.1 2.4 2.2 5.7 2.7 2.1 2.1 2.3 2.3 2.3 2.3 2.1 2.5 4.0 6.4 5.1 5.2 3.4 1.5 1.4 1.2 1.8 29.8 3.5 2.8 2.3 0.0 3.8 0.0 27.1 4.2 1.6 2.9 0.0 1.5 1.6 6.3 5.4 15.6 1.8 1.7 2.2 1.3 2.7 2.6 4.1 7.9 2.5 4.7 3.6 1.4 1.9 20.2 2.0 2.5 2.0 3.1 1.6 2.5 3.1 2.7 1.8 4.7 1.2 26.1 2.1 3.0 1.4 2.6 0.5 2.2 3.3 1.4 2.6 0.7 4.1 338.3 0.0 3.4 2.5 20.3 10.1 2.9 1.0 2.5 2.5 8.3 2.6 0.9 SLC25A1 "CTP, SLC20A3" ENSG00000100075 "Solute carrier family 25 member 1" P53007 22 19175581-19178739 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters" Transport "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 197.7" "Cell type enhanced" "Detected in all" "Hepatocytes: 221.1;Proximal enterocytes: 304.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "eosinophil: 101.9" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 45: Enterocytes - Digestion" "unprognostic (2.12e-1)" "unprognostic (3.98e-1)" "unprognostic (8.17e-2)" "unprognostic (1.13e-1)" "unprognostic (9.39e-2)" "unprognostic (2.61e-2)" "unprognostic (3.11e-2)" "unprognostic (7.12e-2)" "unprognostic (1.06e-1)" "unprognostic (5.74e-2)" "unprognostic (3.90e-2)" "unprognostic (5.72e-2)" "unprognostic (4.52e-2)" "unprognostic (1.84e-1)" "unprognostic (3.46e-2)" "unprognostic (6.14e-2)" "unprognostic (9.03e-2)" 113.3 76.3 45.8 22.3 46.9 14.2 90.3 49.5 58.6 43.5 47.6 63.9 114.1 40.0 16.2 59.2 34.7 21.5 27.3 41.5 65.8 86.8 197.7 33.6 21.4 61.0 58.3 43.6 54.8 33.1 39.3 27.4 73.0 53.9 33.9 5.6 39.5 30.0 17.3 49.1 92.4 21.0 49.4 31.4 52.9 36.3 51.8 16.3 46.1 7.7 25.5 43.9 40.8 55.2 111.9 114.3 85.9 73.6 209.1 102.5 91.2 77.5 96.9 65.7 90.4 136.4 77.2 66.9 38.8 110.5 70.5 95.4 82.9 138.1 37.2 59.6 164.1 35.5 97.7 278.4 148.2 67.3 107.5 145.1 81.7 75.7 58.4 73.3 62.8 53.4 184.6 61.9 74.7 288.1 37.0 80.8 57.5 173.5 70.0 70.4 44.6 29.9 196.2 135.8 55.5 71.2 83.1 163.0 48.6 52.6 122.6 171.7 63.6 80.3 69.3 62.0 53.2 78.2 39.9 35.4 82.5 31.5 41.4 11.6 15.7 101.9 16.6 17.9 10.6 33.3 18.7 18.2 13.7 43.5 16.7 14.3 8.1 13.7 23.8 10.5 19.6 10.6 45.8 46.9 49.5 58.6 41.5 65.8 61.0 58.3 73.0 49.4 51.8 55.2 18.5 9.6 18.9 10.7 35.0 22.0 27.2 21.6 31.9 7.8 44.2 41.9 7.2 38.6 17.0 33.1 2.1 135.6 18.4 178.6 50.9 33.5 30.5 41.4 37.0 16.8 41.0 21.7 5.2 45.6 139.5 27.1 50.4 83.7 2.5 67.5 21.4 221.1 47.5 13.5 6.1 107.3 28.5 30.5 18.2 98.8 28.9 32.6 28.4 2.8 29.6 27.7 16.5 3.0 10.1 39.7 128.1 29.3 38.7 28.7 304.3 127.3 11.1 4.2 13.1 14.5 37.8 15.3 29.5 60.5 30.4 127.7 24.6 55.7 108.3 30.4 SLC25A22 "EIEE3, FLJ13044, GC1, NET44" ENSG00000177542 "Solute carrier family 25 member 22" Q9H936 11 790475-798281 "Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Symport, Transport" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 83.1;pancreas: 83.4" "Cell type enhanced" "Detected in many" "Bipolar cells: 143.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA014662 Approved Uncertain Nucleoplasm,Mitochondria NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 22: Non-specific - Unknown function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 56: Bipolar cells - Visual perception" Mitochondria Nucleoplasm "HPA014662: AB_10600808" "unprognostic (1.01e-2)" "unprognostic (2.12e-1)" "unprognostic (7.28e-2)" "unprognostic (4.68e-2)" "unprognostic (2.09e-3)" "unprognostic (1.43e-1)" "unprognostic (2.72e-3)" "unprognostic (8.67e-3)" "unprognostic (4.19e-2)" "unprognostic (3.70e-1)" "unprognostic (2.46e-2)" "unprognostic (1.16e-1)" "unprognostic (8.97e-3)" "unprognostic (2.61e-2)" "unprognostic (8.47e-2)" "unprognostic (1.08e-1)" "unprognostic (1.50e-1)" 15.8 13.6 49.1 11.0 59.8 7.5 11.2 17.9 83.1 9.0 0.0 10.0 12.9 9.6 2.1 15.2 10.4 4.1 7.7 74.2 7.9 15.1 40.2 15.1 10.1 24.5 11.1 12.7 83.4 4.0 48.7 5.0 25.4 13.9 3.0 16.1 14.4 4.3 2.0 14.2 12.2 3.7 2.4 13.9 13.5 19.1 19.1 6.3 9.4 0.5 6.2 10.3 10.3 40.2 56.2 35.7 20.4 18.6 8.3 14.8 19.4 26.3 21.3 28.0 17.7 34.9 37.1 16.8 19.2 21.6 31.9 48.8 22.4 31.1 6.3 31.9 41.4 15.4 18.2 21.9 35.8 24.7 25.0 14.9 18.6 21.4 22.6 8.8 13.0 19.3 31.8 25.3 12.7 33.9 26.3 23.5 44.8 33.9 53.7 30.9 11.2 38.9 16.8 9.2 100.3 45.3 15.0 35.9 18.7 3.1 17.4 12.5 13.0 32.1 21.5 14.8 25.0 22.1 14.3 21.5 37.8 22.2 19.3 0.0 1.6 2.5 3.7 3.3 2.2 1.3 2.3 3.9 1.8 1.0 1.3 2.3 0.9 2.0 3.4 0.5 1.3 1.6 49.1 59.8 17.9 83.1 74.2 7.9 24.5 11.1 25.4 2.4 19.1 40.2 5.7 6.4 8.6 7.8 8.4 12.6 8.7 9.5 9.1 143.2 9.1 7.5 2.5 8.6 5.0 9.2 33.3 7.1 8.8 3.9 3.9 22.0 12.4 9.5 9.0 7.0 13.1 2.5 11.8 19.3 10.3 5.1 12.8 11.2 2.5 7.2 3.3 17.6 4.3 43.7 10.0 7.6 2.0 2.8 4.6 7.7 4.7 4.1 3.6 3.7 6.6 16.0 13.4 2.5 1.4 14.1 7.8 4.9 13.7 23.8 13.0 7.1 5.8 32.0 0.0 2.8 6.7 1.8 10.4 7.4 13.4 3.1 8.2 13.7 5.9 8.8 SLC25A4 "ANT1, PEO2, PEO3, T1" ENSG00000151729 "Solute carrier family 25 member 4" P12235 4 185143266-185150382 "Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, Transporters" "Antiport, Host-virus interaction, Transport" "Cardiomyopathy, Disease variant, FDA approved drug targets, Primary mitochondrial disease, Progressive external ophthalmoplegia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 9 "heart muscle: 245.1;skeletal muscle: 190.8;tongue: 346.6" "Cell type enriched" "Detected in all" 4 "Cardiomyocytes: 4722.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046835, HPA071684" Approved Supported Mitochondria NA NA 380000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 38: Heart - Muscle contraction" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 54: Cardiomyocytes - Muscle contraction" Mitochondria "HPA046835: AB_2679831, HPA071684: AB_2686431" "unprognostic (4.19e-2)" "unprognostic (1.06e-2)" "unprognostic (3.11e-1)" "unprognostic (8.85e-2)" "unprognostic (1.37e-1)" "unprognostic (2.90e-3)" "unprognostic (8.25e-2)" "unprognostic (1.26e-2)" "unprognostic (7.87e-2)" "unprognostic (1.60e-1)" "prognostic favorable (3.41e-4)" "unprognostic (2.05e-1)" "prognostic favorable (0.00e+0)" "unprognostic (1.98e-1)" "unprognostic (1.05e-1)" "unprognostic (1.73e-1)" "unprognostic (8.28e-3)" 4.7 5.7 14.0 1.6 15.3 0.4 4.6 22.6 30.6 3.4 6.8 21.0 3.0 5.9 3.5 10.1 5.8 3.9 245.1 16.7 11.8 10.4 7.3 4.5 1.5 11.6 10.7 4.9 5.2 7.8 9.5 1.7 11.8 8.9 3.9 19.9 9.0 12.6 190.8 3.3 6.8 8.1 9.4 3.1 15.7 4.7 12.5 1.4 5.2 346.6 1.2 9.8 3.6 18.2 0.7 3.1 2.5 5.1 2.7 0.3 4.6 2.6 0.8 3.1 3.0 6.8 1.7 2.3 1.8 3.1 2.4 2.5 9.8 2.7 2.0 3.9 8.4 1.6 4.7 8.1 5.5 1.4 1.5 2.0 6.6 4.7 1.3 7.2 2.3 4.0 3.8 1.7 1.9 5.0 1.6 3.1 4.1 2.2 6.6 2.5 1.3 3.2 6.9 4.8 8.1 6.2 3.1 1.3 12.5 4.5 2.4 1.1 1.7 0.2 1.4 1.5 3.4 7.3 3.5 2.9 2.2 0.3 2.8 0.0 0.0 0.0 1.7 0.0 1.3 1.5 0.5 1.4 0.0 1.0 0.4 1.2 0.1 0.3 0.0 1.3 0.5 0.6 14.0 15.3 22.6 30.6 16.7 11.8 11.6 10.7 11.8 9.4 12.5 18.2 37.5 86.6 76.4 22.9 37.9 44.1 159.0 119.9 30.1 180.6 42.9 53.5 4722.0 115.8 80.0 71.7 104.3 69.2 41.1 44.4 988.0 75.3 20.6 77.8 7.4 80.1 53.8 3.0 35.1 74.1 56.5 120.1 54.0 33.6 12.0 18.6 27.5 92.1 65.9 159.9 43.7 40.6 215.7 8.5 13.8 16.7 46.6 6.8 190.3 19.7 9.0 541.2 16.5 26.7 29.2 51.4 28.5 112.8 76.4 59.1 113.8 178.3 144.0 221.0 105.2 134.5 402.7 28.0 34.0 33.2 18.2 40.5 27.7 23.7 54.2 50.7 SLC25A46 ENSG00000164209 "Solute carrier family 25 member 46" Q96AG3 5 110738136-110765161 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Transport "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 238.9;Late spermatids: 448.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039601, HPA071582" Approved Supported Mitochondria NA NA "Cluster 44: Non-specific - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 25: Spermatids - Spermatogenesis" Mitochondria "HPA039601: AB_2676592, HPA071582: AB_2686422" "unprognostic (1.86e-1)" "unprognostic (3.29e-1)" "prognostic favorable (8.41e-4)" "unprognostic (4.91e-2)" "unprognostic (2.27e-2)" "unprognostic (2.25e-1)" "unprognostic (2.34e-1)" "unprognostic (1.77e-2)" "unprognostic (5.14e-2)" "unprognostic (1.97e-2)" "unprognostic (1.67e-1)" "unprognostic (2.40e-1)" "unprognostic (2.25e-2)" "unprognostic (2.26e-1)" "unprognostic (2.62e-1)" "prognostic unfavorable (2.52e-4)" "unprognostic (1.98e-1)" 22.9 15.9 10.4 19.9 11.8 17.6 16.4 12.7 16.7 18.5 7.8 22.1 23.8 14.7 10.5 21.2 10.7 15.8 31.1 12.2 12.2 29.7 30.0 16.7 22.5 12.4 10.2 11.7 15.4 20.6 4.9 17.0 13.2 15.7 21.6 18.8 13.3 16.0 55.8 14.9 20.9 20.8 10.3 15.7 20.1 21.9 11.2 24.8 19.8 60.2 26.8 19.0 6.6 14.1 36.2 27.7 25.7 20.7 65.2 60.2 9.9 44.3 55.9 47.5 59.3 37.6 28.7 96.8 44.8 50.1 61.9 29.6 41.0 71.2 54.3 61.8 20.8 40.1 35.2 25.6 53.1 37.3 40.2 49.9 25.4 55.5 39.6 29.5 31.9 37.2 31.4 56.4 54.1 27.3 54.0 17.2 18.1 25.7 24.7 26.0 57.0 71.5 35.1 39.2 46.7 33.5 37.7 29.7 49.7 23.7 30.9 35.3 42.5 43.6 21.0 40.7 54.4 111.8 76.2 68.4 48.0 43.8 24.0 29.2 16.0 13.2 12.3 19.0 12.5 14.4 13.7 12.9 17.0 14.5 14.5 14.8 6.6 20.9 17.7 11.1 18.2 17.4 10.4 11.8 12.7 16.7 12.2 12.2 12.4 10.2 13.2 10.3 11.2 14.1 21.3 22.4 24.8 40.8 26.7 22.9 9.1 16.0 31.9 16.8 15.7 10.8 63.5 11.5 12.9 20.2 22.9 21.7 18.0 34.8 19.6 18.1 238.9 10.4 20.1 18.9 23.4 29.9 73.3 25.6 18.2 22.6 34.7 12.1 19.0 16.2 26.7 43.9 27.2 18.5 63.9 28.3 32.6 26.1 21.0 448.2 21.1 23.9 30.2 31.9 28.1 21.9 17.5 49.8 91.8 18.9 22.8 22.2 73.8 8.0 26.5 41.7 14.9 14.1 19.7 18.5 22.6 23.3 14.2 30.0 26.9 20.5 23.9 22.7 24.0 6.8 SLC26A4 "DFNB4, PDS" ENSG00000091137 "Solute carrier family 26 member 4" O43511 7 107660828-107717809 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" Transport "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 22 "thyroid gland: 263.7" "Cell type enhanced" "Detected in many" "Club cells: 19.0;Excitatory neurons: 29.3;Inhibitory neurons: 53.9;Ionocytes: 54.9;Prostatic glandular cells: 17.3;Urothelial cells: 19.9" "Cancer enriched" "Detected in some" 8 "thyroid cancer: 37.6" "Group enriched" "Detected in many" 88 "amygdala: 4.0;basal ganglia: 10.2;cerebral cortex: 11.8;hippocampal formation: 8.8" "Immune cell enriched" "Detected in single" 8 "naive B-cell: 1.0" "Lineage enriched" "Detected in single" 8 "B-cells: 1.0" "Cell line enhanced" "Detected in some" "HDLM-2: 1.6;hTERT-RPE1: 3.7;LHCN-M2: 2.1" "Region enriched" "Detected in many" 4 "hippocampal formation: 9.7" "Region enhanced" "Detected in some" "hippocampal formation: 4.8" HPA042860 Approved NA NA "Cluster 24: B-cells - Unknown function" "Cluster 1: Thyroid gland - Transcription" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA042860: AB_10796680" "unprognostic (1.19e-2)" "unprognostic (4.84e-2)" "unprognostic (5.44e-2)" "unprognostic (8.44e-2)" "unprognostic (3.25e-2)" "unprognostic (3.26e-2)" "unprognostic (6.69e-2)" "unprognostic (1.85e-1)" "unprognostic (5.72e-2)" "unprognostic (9.58e-2)" "unprognostic (1.60e-1)" "unprognostic (1.03e-1)" "unprognostic (6.46e-3)" "unprognostic (1.51e-1)" "unprognostic (1.71e-1)" "unprognostic (1.41e-2)" "unprognostic (1.39e-1)" 0.4 0.1 4.0 0.1 10.2 0.0 0.8 0.0 11.8 1.4 0.0 0.2 0.1 0.5 0.1 0.1 0.3 0.4 0.6 8.8 0.0 6.4 0.1 0.5 0.4 0.0 0.0 0.3 0.3 3.9 0.3 0.3 0.0 3.8 0.2 0.1 0.4 0.2 0.5 0.2 0.1 0.3 0.0 0.1 0.7 0.6 0.0 0.2 263.7 0.1 0.2 1.5 0.3 0.0 0.3 0.1 0.2 0.0 0.3 0.6 0.2 0.1 0.1 0.1 0.0 0.0 0.0 0.0 1.1 0.1 0.0 0.1 0.2 0.0 0.0 1.6 0.4 0.0 0.1 0.1 0.1 0.1 0.5 0.0 0.4 0.2 0.0 3.7 0.0 0.3 0.0 0.1 2.1 0.3 0.0 0.2 0.0 0.0 0.3 0.0 0.5 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.8 0.0 0.0 0.2 0.3 0.3 0.2 0.1 1.3 0.3 0.3 0.1 0.3 0.2 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 4.0 10.2 0.0 11.8 8.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 3.2 7.7 2.6 0.2 1.7 0.7 6.5 0.0 6.6 3.2 1.8 0.6 0.0 19.0 0.0 2.1 0.3 0.4 0.4 0.0 0.2 3.9 0.3 0.5 4.9 7.3 0.0 29.3 0.0 0.1 1.5 0.0 1.8 5.1 0.2 1.1 0.2 0.3 1.7 53.9 0.0 54.9 0.6 2.0 2.7 0.9 0.7 7.2 3.7 0.7 1.2 1.0 1.5 1.6 0.1 0.1 1.2 0.0 17.3 0.0 0.1 15.2 1.8 0.0 2.9 1.6 2.0 0.4 0.1 1.4 0.0 1.7 0.2 0.5 19.9 SLC26A5 "DFNB61, PRES" ENSG00000170615 "Solute carrier family 26 member 5" P58743 7 103352730-103446207 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Cell shape, Hearing" "Motor protein" "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in single" "brain: 2.2" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 6.4;Astrocytes: 5.5;Excitatory neurons: 4.1;Gastric mucus-secreting cells: 7.1;Hepatic stellate cells: 5.3;Inhibitory neurons: 3.5;Microglial cells: 6.5;Oligodendrocytes: 4.2" "Low cancer specificity" "Detected in single" "Region enhanced" "Detected in single" "cerebellum: 2.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in many" 4 "basal ganglia: 10.4" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 48: Smooth muscle cells - ECM organization" "unprognostic (3.86e-2)" "unprognostic (5.13e-2)" "unprognostic (6.38e-3)" "unprognostic (2.76e-2)" "unprognostic (1.02e-2)" "unprognostic (5.09e-2)" "unprognostic (2.36e-1)" "unprognostic (3.56e-4)" "unprognostic (4.21e-3)" "unprognostic (8.92e-3)" "unprognostic (2.82e-1)" "unprognostic (2.97e-1)" "unprognostic (3.67e-5)" "unprognostic (3.05e-1)" "unprognostic (2.81e-1)" "unprognostic (2.94e-2)" "unprognostic (2.69e-3)" 0.1 0.1 0.3 0.0 0.3 0.0 0.7 2.2 0.2 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.2 0.4 0.1 0.4 0.5 0.0 0.2 0.3 0.0 0.0 0.3 0.4 0.0 0.1 0.2 0.0 0.0 0.2 0.0 0.0 0.4 0.1 0.6 0.2 0.3 0.0 0.2 0.0 0.0 0.3 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 2.2 0.2 0.1 0.4 0.4 0.5 0.3 0.4 0.3 0.5 0.3 6.4 2.6 5.5 0.2 0.3 0.0 0.0 0.0 0.2 0.3 0.1 0.7 0.0 0.6 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.4 0.2 0.5 0.0 0.0 4.1 0.0 0.0 2.2 7.1 0.2 0.0 0.0 5.3 0.0 0.0 0.0 3.5 0.0 0.0 0.3 0.3 0.0 0.3 0.0 0.0 6.5 0.0 0.3 0.0 2.0 4.2 0.3 0.0 0.0 0.0 0.8 0.0 0.0 2.2 1.2 0.0 0.2 0.1 0.3 0.5 0.0 0.3 0.0 0.6 0.0 0.0 0.6 SLC2A1 "CSE, DYT18, DYT9, GLUT, GLUT1, HTLVR" ENSG00000117394 "Solute carrier family 2 member 1" P11166 1 42925353-42958893 "Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Sugar transport, Transport" "Cancer-related genes, Cataract, Disease variant, Dystonia, Epilepsy, Hereditary hemolytic anemia, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 98.7;skin 1: 79.8" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 833.8;Erythroid cells: 520.4;Extravillous trophoblasts: 536.4;Syncytiotrophoblasts: 2482.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "BEWO: 241.0;CACO-2: 219.9;Hep G2: 157.4" "Low region specificity" "Detected in all" "CAB002759, HPA031345, HPA058494" Enhanced Supported Enhanced "Plasma membrane" No No 2000000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 27: Brain & Skin - Unknown function" "Cluster 39: CACO-2 - Unknown function" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" "Plasma membrane" "CAB002759: , HPA031345: AB_2673835, HPA058494: AB_2683734" "unprognostic (3.60e-2)" "unprognostic (5.85e-3)" "unprognostic (7.59e-2)" "unprognostic (1.31e-2)" "unprognostic (4.10e-3)" "unprognostic (3.22e-2)" "prognostic unfavorable (3.65e-8)" "prognostic unfavorable (1.09e-4)" "unprognostic (1.10e-1)" "unprognostic (4.84e-2)" "prognostic unfavorable (4.39e-5)" "unprognostic (1.87e-1)" "prognostic unfavorable (4.55e-9)" "unprognostic (1.11e-1)" "unprognostic (9.49e-2)" "unprognostic (1.17e-1)" "prognostic unfavorable (4.05e-4)" 6.9 3.6 24.1 2.5 26.1 41.6 7.8 33.7 27.7 28.6 43.6 6.1 0.4 5.1 1.4 54.1 8.2 1.7 10.0 20.6 28.5 14.2 1.7 3.3 1.0 31.9 29.3 5.5 2.1 4.5 4.8 98.7 34.5 6.0 1.0 24.6 17.6 5.1 2.0 79.8 4.6 0.4 24.7 7.5 8.4 2.1 41.2 1.0 3.0 1.5 2.1 19.3 54.2 29.4 60.5 52.9 66.3 6.2 3.5 1.2 241.0 47.8 36.9 15.5 27.8 219.9 96.3 22.2 138.9 6.0 26.5 43.6 12.5 52.3 14.8 16.4 10.3 29.8 20.9 157.4 12.9 16.8 8.1 3.3 21.3 18.3 20.5 96.7 2.9 12.8 81.2 1.5 11.7 46.6 7.4 11.7 35.1 22.1 17.9 8.4 20.6 23.3 21.7 17.9 27.0 23.8 47.7 95.6 11.0 70.0 3.8 16.9 14.9 25.6 28.6 6.1 83.8 5.3 6.5 11.5 57.1 8.2 25.5 0.5 0.1 1.2 10.6 0.3 8.5 10.9 5.1 6.7 3.7 8.3 3.8 4.8 0.2 4.3 0.1 18.4 6.2 4.0 24.1 26.1 33.7 27.7 20.6 28.5 31.9 29.3 34.5 24.7 41.2 29.4 3.1 0.0 1.8 12.7 25.4 286.1 48.8 286.3 66.0 15.8 41.4 21.8 26.7 20.0 159.3 27.6 66.7 833.8 33.5 53.1 5.9 53.2 4.0 112.1 46.0 100.5 18.4 520.4 2.8 11.7 536.4 25.9 11.7 118.9 6.3 6.8 2.2 2.1 84.8 5.0 3.2 22.4 65.1 1.6 34.2 0.3 7.8 5.0 21.4 71.2 36.0 350.1 18.6 8.0 9.9 120.3 51.9 14.7 11.6 31.2 1.9 2.2 118.1 32.1 0.0 9.8 32.1 0.1 2.4 99.1 238.3 2482.5 20.8 5.5 11.8 105.8 SLC33A1 "ACATN, AT-1, AT1, SPG42" ENSG00000169359 "Solute carrier family 33 member 1" O00400 3 155821024-155854456 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" Transport "Cataract, Deafness, Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042430 Uncertain Approved Vesicles,Cytosol NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 29: Non-specific - Vesicular transport" "Cluster 30: Epithelial cell lines - Translation" "Cluster 55: Plasma cells - Humoral immune response" "Vesicles, Cytosol" "HPA042430: AB_10806238" "unprognostic (5.12e-3)" "unprognostic (7.78e-2)" "unprognostic (1.13e-2)" "unprognostic (7.21e-2)" "unprognostic (1.88e-2)" "unprognostic (1.34e-1)" "unprognostic (2.73e-2)" "unprognostic (9.57e-2)" "unprognostic (5.65e-2)" "unprognostic (6.61e-2)" "unprognostic (4.36e-2)" "unprognostic (1.19e-1)" "unprognostic (1.93e-1)" "unprognostic (2.08e-2)" "unprognostic (2.92e-1)" "unprognostic (4.73e-2)" "unprognostic (5.74e-2)" 8.8 11.0 3.9 4.9 4.8 2.9 8.4 4.6 4.7 12.3 9.2 7.2 6.9 8.8 12.9 8.0 9.5 7.8 7.6 4.6 5.3 10.4 17.2 8.4 5.0 4.4 4.2 8.0 30.9 11.6 5.9 6.6 4.6 8.3 6.4 6.8 11.2 11.0 4.7 6.4 7.7 7.1 5.2 5.8 8.8 5.4 5.2 7.1 18.8 4.8 6.2 6.8 7.9 7.3 18.9 17.7 7.3 8.3 24.4 23.5 12.9 13.1 21.2 19.8 18.7 8.5 22.0 9.9 24.1 13.1 19.8 17.1 14.3 15.2 20.8 16.5 13.3 11.3 6.5 15.8 41.5 13.3 8.9 18.4 26.7 9.7 49.5 20.5 19.8 12.4 8.6 27.8 14.3 14.3 5.0 3.7 6.8 17.7 14.9 5.6 8.1 29.1 9.7 11.8 7.9 5.9 11.1 24.5 21.4 11.3 8.1 11.2 21.4 10.1 4.9 17.9 13.1 33.2 14.4 12.3 14.6 8.8 14.0 12.7 8.4 6.2 8.9 6.3 9.6 5.4 6.0 6.8 10.4 3.5 5.4 5.5 1.7 6.6 6.5 16.1 5.7 5.9 3.9 4.8 4.6 4.7 4.6 5.3 4.4 4.2 4.6 5.2 5.2 7.3 9.0 22.4 25.0 16.0 14.8 8.9 11.7 20.8 18.2 17.5 16.0 9.0 23.8 18.6 21.5 11.0 27.1 18.2 21.1 14.2 5.9 15.3 13.7 11.2 20.3 13.7 12.5 8.4 17.9 15.4 28.3 19.7 20.9 16.6 12.0 12.8 16.4 64.3 19.5 18.5 17.4 18.1 12.2 14.7 15.8 13.2 18.6 15.2 12.4 10.3 19.0 15.4 12.3 11.1 20.8 14.4 5.3 21.4 33.3 19.5 18.9 17.1 23.4 23.0 13.1 16.0 16.0 19.5 9.2 12.2 9.5 37.6 15.3 10.2 13.9 10.9 SLC35A2 "UGALT, UGAT, UGT, UGT1, UGT2, UGTL" ENSG00000102100 "Solute carrier family 35 member A2" P78381 X 48903180-48911958 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Sugar transport, Transport" "Congenital disorder of glycosylation, Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036087 Approved Supported "Golgi apparatus" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 30: Mammary glandular cells - Lactation" "Golgi apparatus" "HPA036087: AB_10604093" "prognostic unfavorable (3.16e-4)" "unprognostic (3.34e-1)" "unprognostic (4.88e-3)" "unprognostic (1.11e-1)" "unprognostic (8.15e-3)" "unprognostic (4.25e-3)" "prognostic unfavorable (9.64e-5)" "unprognostic (3.47e-1)" "unprognostic (2.50e-1)" "unprognostic (1.63e-1)" "unprognostic (1.94e-3)" "unprognostic (9.58e-2)" "unprognostic (3.16e-2)" "prognostic favorable (8.23e-4)" "unprognostic (1.38e-1)" "unprognostic (1.61e-1)" "unprognostic (5.13e-2)" 15.8 20.5 13.7 12.7 14.3 15.9 14.9 14.3 14.8 18.7 19.4 29.3 17.3 13.1 28.4 24.7 32.6 15.2 15.0 14.5 15.8 19.8 31.8 18.2 11.4 14.6 15.0 9.3 30.0 24.7 21.3 19.9 15.4 17.1 28.2 3.1 23.8 14.8 14.0 21.9 18.0 11.7 14.4 14.7 25.0 7.1 15.9 11.8 15.4 7.2 14.7 19.8 15.4 15.9 48.8 55.2 18.8 27.3 36.5 31.6 29.7 49.7 54.1 51.3 59.9 64.0 84.5 18.8 22.2 54.2 64.4 67.0 51.7 40.0 39.7 27.9 34.0 20.5 33.1 49.6 47.8 38.7 40.9 35.7 69.9 48.6 39.8 28.9 30.6 25.9 38.7 29.8 37.6 47.1 20.5 35.0 39.7 55.3 67.7 22.3 35.5 61.1 44.4 39.1 21.8 36.1 52.9 54.5 28.7 35.1 80.8 30.7 28.2 30.3 30.6 55.4 27.5 45.1 32.8 19.6 38.4 34.1 40.3 18.1 22.3 40.0 15.3 23.4 15.8 10.7 12.6 13.9 27.7 9.9 8.3 14.6 24.2 13.8 17.5 27.7 13.1 11.9 13.7 14.3 14.3 14.8 14.5 15.8 14.6 15.0 15.4 14.4 15.9 15.9 16.2 9.6 17.0 3.3 13.1 14.1 11.7 29.0 2.8 4.5 26.5 10.9 5.2 10.0 23.5 16.5 0.0 31.0 15.6 24.1 3.9 27.4 3.3 24.2 12.0 13.5 12.7 19.0 2.6 32.3 30.6 14.0 18.8 16.8 2.5 8.0 11.0 15.6 23.4 6.7 2.5 31.5 28.5 10.1 14.5 1.3 9.9 12.3 10.6 4.7 21.9 9.4 8.2 4.5 4.4 27.1 19.7 10.9 19.3 18.7 17.8 10.5 50.5 5.7 6.6 9.7 19.4 10.3 6.8 10.9 17.5 48.0 13.8 12.2 21.7 23.4 SLC38A8 ENSG00000166558 "Solute carrier family 38 member 8" A6NNN8 16 84009667-84042795 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Amino-acid transport, Ion transport, Sodium transport, Transport" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in single" 5 "brain: 3.9" "Cell type enriched" "Detected in some" 4 "Late spermatids: 16.1" "Cancer enriched" "Detected in single" 14 "melanoma: 6.5" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "SCLC-21H: 2.5" "Low region specificity" "Detected in single" "Not detected" "Not detected" NA NA "Cluster 65: Brain - Ion transport" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 31: Spermatids - Spermatogenesis" "unprognostic (9.69e-2)" "unprognostic (6.16e-2)" "unprognostic (8.00e-3)" "unprognostic (6.40e-2)" "unprognostic (1.03e-1)" "unprognostic (8.20e-3)" "unprognostic (1.89e-1)" "unprognostic (7.70e-2)" "unprognostic (2.59e-1)" "unprognostic (2.16e-2)" "unprognostic (3.54e-2)" "unprognostic (1.37e-1)" "unprognostic (1.45e-1)" 0.0 0.1 3.7 0.0 3.9 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.7 1.0 0.8 0.0 0.1 0.0 0.0 1.1 1.6 0.0 0.2 0.1 0.7 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.3 0.4 3.0 0.5 0.0 0.1 0.0 0.0 0.0 1.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.7 3.9 0.0 1.3 1.0 0.8 1.1 1.6 0.9 0.6 3.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.2 0.0 0.1 0.0 0.0 0.6 0.2 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 1.0 0.0 1.4 0.0 0.0 0.0 0.0 16.1 0.6 0.0 0.0 0.0 0.0 0.3 0.0 0.5 0.2 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.7 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SLC39A5 ENSG00000139540 "Solute carrier family 39 member 5" Q6ZMH5 12 56230049-56237846 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Ion transport, Transport, Zinc transport" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 32 "intestine: 237.4;kidney: 110.0;liver: 171.1;pancreas: 306.8" "Cell type enriched" "Detected in some" 4 "Proximal enterocytes: 798.4" "Cancer enhanced" "Detected in many" "colorectal cancer: 30.6;liver cancer: 36.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 53 "CACO-2: 39.9;Hep G2: 58.5" "Region enhanced" "Detected in single" "basal ganglia: 1.1" "Not detected" "Not detected" HPA018423 Approved Nucleoplasm,Vesicles NA NA "Cluster 29: Non-specific - Vesicular transport" "Cluster 39: CACO-2 - Unknown function" "Cluster 45: Enterocytes - Digestion" Vesicles Nucleoplasm "HPA018423: AB_1857154" "unprognostic (5.94e-3)" "unprognostic (8.29e-2)" "unprognostic (1.82e-2)" "unprognostic (2.19e-7)" "unprognostic (1.73e-1)" "unprognostic (7.79e-2)" "unprognostic (1.56e-1)" "unprognostic (1.36e-1)" "unprognostic (1.08e-1)" "unprognostic (1.32e-1)" "unprognostic (7.33e-2)" "unprognostic (2.93e-3)" "prognostic favorable (5.05e-4)" "unprognostic (2.75e-1)" "unprognostic (1.15e-1)" "unprognostic (1.23e-1)" "unprognostic (1.96e-4)" 0.3 0.1 0.2 5.5 0.2 0.1 0.3 0.5 0.4 0.3 0.2 73.7 237.4 0.4 0.0 0.1 0.3 6.5 0.2 0.1 0.1 110.0 171.1 0.2 0.4 0.2 0.1 0.4 306.8 0.0 0.2 0.1 0.1 0.3 45.9 6.4 0.1 0.3 0.1 0.3 219.0 2.6 0.1 0.3 1.4 0.2 0.1 0.0 0.3 0.2 0.0 0.2 0.2 0.1 0.0 0.3 0.1 0.2 0.2 0.3 0.5 0.0 0.0 0.1 0.0 39.9 0.4 0.1 0.1 0.1 0.0 0.2 0.0 0.3 0.0 0.6 0.1 0.2 0.2 58.5 0.2 0.1 0.2 0.2 0.1 0.2 0.0 0.1 0.0 0.1 0.1 0.3 0.0 0.2 0.0 0.8 0.0 0.9 0.1 0.2 0.2 0.3 0.5 0.1 0.3 0.4 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.4 0.0 0.1 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.5 0.4 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 1.4 0.6 0.1 0.0 0.0 0.9 0.1 0.3 0.2 15.7 0.0 3.7 116.7 0.0 0.0 171.9 19.6 0.3 0.6 0.0 0.1 0.2 25.3 2.7 0.2 20.6 0.0 0.1 0.0 0.0 0.0 0.0 2.2 138.9 0.1 0.0 0.2 112.7 0.0 1.6 1.2 1.4 0.0 1.3 0.0 0.0 0.6 0.6 0.0 0.0 0.1 7.4 192.8 0.0 0.0 0.1 798.4 169.9 0.0 1.8 0.0 0.2 0.2 0.0 0.0 0.0 0.4 0.0 0.8 0.0 168.7 0.0 SLC44A4 "C6orf29, CTL4, DFNA72, FLJ14491, NG22, TPPT" ENSG00000204385 "Solute carrier family 44 member 4" Q53GD3 6 31863192-31879046 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 132.0;prostate: 83.0;stomach 1: 83.4" "Cell type enhanced" "Detected in many" "Distal enterocytes: 546.0;Exocrine glandular cells: 213.4;Intestinal goblet cells: 327.8;Paneth cells: 299.3;Proximal enterocytes: 267.7;Respiratory ciliated cells: 406.7;Undifferentiated cells: 259.6" "Cancer enhanced" "Detected in many" "prostate cancer: 222.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 8 "OE19: 14.6" "Not detected" "Not detected" "Not detected" "Not detected" "HPA046977, HPA054176" Enhanced NA NA "Cluster 9: Intestine - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA046977: AB_2679887, HPA054176: AB_2682404" "unprognostic (5.84e-2)" "unprognostic (4.90e-2)" "unprognostic (3.86e-3)" "unprognostic (4.85e-3)" "unprognostic (2.75e-2)" "prognostic favorable (3.54e-4)" "unprognostic (2.65e-3)" "unprognostic (2.44e-3)" "unprognostic (3.08e-1)" "unprognostic (2.45e-1)" "unprognostic (2.89e-2)" "unprognostic (1.89e-1)" "prognostic favorable (1.06e-6)" "unprognostic (1.37e-2)" "unprognostic (2.48e-1)" "unprognostic (4.54e-2)" "prognostic favorable (6.06e-4)" 0.8 8.2 0.0 2.5 0.0 1.0 5.3 0.0 0.0 22.4 0.0 132.0 100.8 5.9 2.5 2.0 46.9 18.8 0.0 0.0 0.0 32.1 0.4 14.9 0.1 0.3 0.1 1.6 8.9 0.0 16.1 3.5 0.1 83.0 30.3 0.0 42.6 3.9 0.0 1.1 86.8 2.9 0.0 1.6 83.4 0.7 0.0 0.2 1.9 0.0 0.7 11.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 14.6 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.3 0.0 0.7 0.0 0.0 0.0 0.3 0.7 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.1 0.0 0.0 0.0 3.7 22.4 36.0 0.0 3.8 0.5 23.0 71.4 0.6 0.3 14.6 6.1 0.4 38.6 180.2 66.2 0.0 0.3 0.5 546.0 3.9 111.2 2.3 127.4 8.9 6.2 46.7 0.0 0.1 213.4 0.5 2.4 208.5 67.5 2.5 1.1 0.4 0.0 0.5 0.0 0.1 327.8 91.6 0.0 0.0 3.2 1.5 2.5 0.0 0.0 1.6 0.7 0.0 0.0 0.0 184.0 299.3 0.4 0.3 142.0 267.7 61.5 406.7 0.6 0.0 0.8 11.9 0.2 0.2 0.5 0.4 0.7 2.3 5.5 259.6 139.4 SLC4A11 "BTR1, CDPD1, CHED2, dJ794I6.2, FECD4, NaBC1" ENSG00000088836 "Solute carrier family 4 member 11" Q8NBS3 20 3227417-3239559 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Anion exchange, Ion transport, Symport, Transport" "Corneal dystrophy, Deafness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 51.3;salivary gland: 54.0;thyroid gland: 60.9" "Cell type enhanced" "Detected in many" "Club cells: 25.5;Collecting duct cells: 112.2;Ionocytes: 79.3;Respiratory ciliated cells: 48.1;Sertoli cells: 26.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HaCaT: 70.6;Hep G2: 43.0;RT4: 30.7" "Low region specificity" "Detected in single" "Low region specificity" "Detected in many" "HPA018120, HPA058377" Uncertain Uncertain Nucleoplasm,Vesicles NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 7: Kidney - Transmembrane transport" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Nucleoplasm Vesicles "HPA018120: AB_1857186, HPA058377: " "unprognostic (2.33e-1)" "prognostic favorable (9.03e-4)" "unprognostic (1.18e-2)" "unprognostic (3.05e-2)" "unprognostic (1.00e-1)" "unprognostic (6.52e-2)" "unprognostic (9.66e-3)" "unprognostic (3.73e-2)" "unprognostic (3.10e-3)" "unprognostic (1.52e-3)" "unprognostic (2.94e-1)" "unprognostic (2.64e-1)" "prognostic favorable (6.21e-6)" "unprognostic (7.37e-2)" "unprognostic (4.30e-1)" "unprognostic (2.33e-1)" "unprognostic (6.89e-3)" 2.4 6.9 4.5 0.7 3.5 0.4 3.4 2.3 3.1 10.9 5.6 0.4 0.1 0.5 2.6 16.5 1.7 1.1 0.8 2.9 1.4 51.3 0.2 2.0 1.4 2.0 2.3 0.2 0.5 0.6 4.3 0.2 2.6 5.4 0.3 0.4 54.0 7.0 5.2 12.8 0.6 0.3 0.8 0.7 2.5 5.9 4.3 1.0 60.9 0.1 1.8 3.4 5.8 1.9 11.0 15.5 1.8 7.9 5.1 1.3 21.1 5.4 3.4 2.8 1.6 1.1 14.1 0.0 6.1 1.9 6.6 70.6 8.3 16.8 0.5 0.1 3.2 0.7 7.5 43.0 3.2 4.0 13.6 0.7 6.8 3.4 3.2 2.3 7.0 9.8 1.6 9.7 2.9 7.2 0.5 0.4 12.1 13.6 20.7 2.6 10.3 3.5 16.9 30.7 0.9 4.9 2.7 17.5 0.3 5.4 6.7 7.0 12.1 2.1 7.0 0.5 2.7 0.4 0.6 0.1 0.1 2.8 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 4.5 3.5 2.3 3.1 2.9 1.4 2.0 2.3 2.6 0.8 4.3 1.9 0.8 0.0 0.0 1.6 0.0 0.8 2.2 16.3 8.0 0.2 4.9 4.4 1.1 0.0 25.5 112.2 0.0 0.1 0.6 0.8 0.0 0.7 5.8 2.3 0.6 0.7 0.0 0.0 0.3 0.5 0.1 0.3 5.1 4.2 0.0 0.2 1.1 0.0 0.4 0.0 0.1 0.2 79.3 0.3 0.0 2.2 0.0 0.5 0.0 0.0 0.6 0.1 0.0 0.0 0.3 3.0 1.3 0.4 0.0 3.7 0.0 0.5 48.1 0.2 26.3 0.6 5.8 3.0 4.7 3.3 0.4 0.0 0.2 0.1 0.2 5.7 SLC52A2 "D15Ertd747e, FLJ11856, GPCR41, GPR172A, hRFT3, PAR1, RFVT2" ENSG00000185803 "Solute carrier family 52 member 2" Q9HAB3 8 144333957-144361286 "Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Transport "Host cell receptor for virus entry, Receptor" "Deafness, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MCF7: 149.0;PC-3: 167.6" "Low region specificity" "Detected in all" HPA063036 Approved NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 18: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA063036: AB_2684928" "unprognostic (7.80e-3)" "prognostic unfavorable (7.55e-4)" "unprognostic (2.15e-1)" "unprognostic (2.94e-1)" "unprognostic (3.09e-2)" "unprognostic (3.94e-2)" "prognostic unfavorable (2.04e-6)" "unprognostic (7.74e-3)" "unprognostic (9.20e-2)" "unprognostic (2.24e-2)" "unprognostic (4.85e-2)" "unprognostic (3.99e-2)" "prognostic unfavorable (1.23e-4)" "unprognostic (3.12e-2)" "unprognostic (1.73e-1)" "unprognostic (1.51e-1)" "unprognostic (1.07e-1)" 29.7 31.6 13.7 5.4 13.4 5.6 27.8 15.3 18.5 21.7 14.5 35.7 9.4 23.0 8.0 33.3 17.3 3.2 26.4 13.5 14.5 29.2 16.9 24.6 5.6 15.0 14.9 15.6 41.6 5.3 24.5 7.7 14.6 22.2 5.7 1.3 29.8 6.3 13.5 30.4 29.6 4.3 14.0 34.8 31.4 31.5 15.1 4.0 21.7 2.7 4.1 24.9 21.2 14.1 38.7 65.0 7.5 17.9 19.3 12.3 37.3 28.1 18.9 26.5 24.6 57.9 42.3 16.3 42.3 27.5 20.7 42.6 18.4 25.3 9.8 18.3 34.5 26.3 31.3 50.1 51.7 9.4 29.4 14.8 34.7 27.4 24.4 19.2 15.8 16.2 40.9 23.7 18.7 149.0 15.6 38.0 17.9 51.5 167.6 29.8 8.9 44.9 30.6 34.4 25.9 29.4 31.1 44.1 35.7 9.9 27.8 18.7 20.2 20.9 46.9 48.2 37.9 9.4 13.8 12.4 37.8 26.6 25.7 0.5 4.2 9.2 5.6 5.9 3.8 3.3 3.9 5.6 4.5 9.8 3.6 2.6 1.1 5.2 7.5 7.6 5.7 1.5 13.7 13.4 15.3 18.5 13.5 14.5 15.0 14.9 14.6 14.0 15.1 14.1 31.9 6.4 8.7 5.5 24.3 31.2 27.0 41.5 12.0 11.1 30.6 17.0 3.1 12.8 34.4 12.9 2.1 85.0 36.3 81.8 0.0 62.3 3.3 11.6 16.6 24.3 17.4 7.8 3.2 66.9 92.1 22.2 42.3 21.5 10.2 16.6 18.9 5.5 52.4 11.8 3.7 56.3 36.7 13.5 27.8 5.8 12.8 21.4 30.2 2.8 40.7 14.3 19.6 7.1 2.4 85.1 46.7 19.9 43.3 54.7 52.4 14.5 11.7 10.8 19.7 12.1 31.1 34.0 40.2 20.2 36.1 52.5 24.8 23.4 65.6 36.7 SLC52A3 "bA371L19.1, C20orf54, hRFT2, RFVT3" ENSG00000101276 "Solute carrier family 52 member 3" Q9NQ40 20 760080-776015 "Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters" Transport "Deafness, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 19.2;testis: 40.1" "Cell type enhanced" "Detected in many" "Collecting duct cells: 23.9;Cytotrophoblasts: 32.8;Distal enterocytes: 18.8;Glandular and luminal cells: 21.3;Paneth cells: 21.7;Proximal enterocytes: 35.5;Syncytiotrophoblasts: 52.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "basophil: 2.1" "Lineage enriched" "Detected in single" 4 "granulocytes: 2.1" "Cell line enhanced" "Detected in some" "CAPAN-2: 42.1;OE19: 31.8;RT4: 12.3;SK-BR-3: 15.4;T-47d: 20.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA049391, HPA059078" Approved NA NA "Cluster 11: Basophils - Unknown function" "Cluster 78: Testis - Spermatogenesis" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" "HPA049391: AB_2680743, HPA059078: AB_2732630" "unprognostic (4.53e-2)" "unprognostic (1.11e-1)" "unprognostic (8.60e-2)" "unprognostic (7.84e-2)" "unprognostic (1.29e-1)" "unprognostic (9.03e-3)" "unprognostic (2.12e-3)" "unprognostic (1.43e-3)" "unprognostic (1.15e-2)" "unprognostic (4.36e-2)" "unprognostic (4.39e-3)" "unprognostic (4.82e-2)" "unprognostic (2.04e-3)" "prognostic favorable (5.51e-6)" "unprognostic (3.04e-1)" "unprognostic (2.21e-1)" "unprognostic (1.44e-1)" 2.1 0.2 11.0 1.5 8.9 0.4 2.6 9.5 11.4 2.3 5.5 11.5 14.4 2.0 2.0 4.9 1.8 2.6 5.7 9.0 11.1 9.4 0.1 1.2 0.4 12.9 9.8 0.9 1.6 0.2 0.3 4.3 12.3 8.0 7.1 0.6 6.1 4.0 0.6 1.8 19.2 1.7 9.8 0.2 5.6 40.1 12.5 0.1 0.5 0.9 0.8 4.9 2.5 9.7 6.6 2.2 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.1 4.6 42.1 0.0 7.0 0.0 0.6 6.9 0.0 6.0 0.0 0.0 0.0 0.8 0.7 0.3 0.0 0.0 0.3 0.0 1.8 0.0 0.0 0.1 0.0 0.0 0.2 0.3 0.0 0.1 0.0 0.1 0.6 31.8 4.5 0.0 0.0 1.1 0.0 12.3 0.1 0.2 7.2 15.4 0.1 0.8 20.1 0.0 0.0 0.2 0.1 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.1 2.1 0.2 0.3 0.2 0.0 0.2 0.2 0.2 0.1 0.0 0.4 0.2 0.3 0.8 0.5 0.1 0.3 0.1 0.2 11.0 8.9 9.5 11.4 9.0 11.1 12.9 9.8 12.3 9.8 12.5 9.7 3.8 9.6 3.1 0.0 0.1 0.6 2.2 5.3 1.8 0.4 3.2 2.4 0.7 4.3 5.3 23.9 2.1 32.8 0.0 18.8 1.9 6.6 1.1 8.9 1.1 10.8 0.0 0.0 0.1 2.0 0.9 0.4 4.6 21.3 0.0 5.9 0.0 0.0 2.6 0.0 0.0 6.0 6.1 0.0 1.3 3.2 0.9 0.2 1.8 2.8 0.0 0.0 0.0 0.0 0.0 5.2 21.7 0.4 0.1 4.3 35.5 0.1 2.4 0.1 0.0 0.4 0.6 0.6 0.8 2.3 1.1 52.1 0.2 1.3 10.8 5.8 SLC5A7 "CHT1, hCHT" ENSG00000115665 "Solute carrier family 5 member 7" Q9GZV3 2 107986523-108013994 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Ion transport, Neurotransmitter biosynthesis, Sodium transport, Symport, Transport" "Congenital myasthenic syndrome, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 12 "brain: 32.9" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 3.2;Club cells: 3.1;Respiratory ciliated cells: 1.5" "Cancer enhanced" "Detected in single" "testis cancer: 0.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 20 "RT4: 3.6;SCLC-21H: 1.0" "Group enriched" "Detected in many" 4 "basal ganglia: 23.1;hypothalamus: 9.0;midbrain: 9.4;pons and medulla: 14.4;thalamus: 6.2" "Group enriched" "Detected in many" 6 "basal ganglia: 20.4;pons: 26.5;spinal cord: 46.7" HPA046105 Approved "Nuclear bodies,Cell Junctions,Intermediate filaments" NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 15: RT4 - Unknown function" "Cluster 49: Ciliated cells - Cilium organization" "Cell Junctions, Intermediate filaments" "Nuclear bodies" "HPA046105: " "unprognostic (2.98e-1)" "unprognostic (1.01e-1)" "unprognostic (1.29e-3)" "unprognostic (7.10e-2)" "unprognostic (1.66e-1)" "unprognostic (3.39e-4)" "unprognostic (1.05e-2)" "unprognostic (9.78e-3)" "unprognostic (6.42e-2)" "unprognostic (1.61e-2)" 0.1 0.7 1.1 0.5 3.0 0.0 0.1 0.0 10.3 0.7 1.0 2.6 0.7 0.1 0.1 0.3 0.1 0.1 0.3 0.2 5.3 0.3 0.0 0.2 0.0 20.2 21.2 0.2 0.1 0.0 0.0 0.0 32.9 0.3 0.7 0.9 0.3 1.1 0.0 0.0 0.8 0.7 2.8 0.0 0.5 0.1 1.6 0.0 1.2 0.1 0.0 1.3 0.6 7.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 1.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 3.0 0.0 10.3 0.2 5.3 20.2 21.2 32.9 2.8 1.6 7.0 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.3 0.0 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.3 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.3 SLC6A1 "GABATHG, GABATR, GAT1" ENSG00000157103 "Solute carrier family 6 member 1" P30531 3 10992186-11039247 "Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, Transporters" "Neurotransmitter transport, Symport, Transport" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 71.3;liver: 87.3;retina: 37.0" "Group enriched" "Detected in some" 4 "Astrocytes: 221.0;Inhibitory neurons: 332.3;Microglial cells: 108.7;Oligodendrocyte precursor cells: 130.2;Oligodendrocytes: 107.9" "Group enriched" "Detected in some" 16 "glioma: 16.1;liver cancer: 24.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HeLa: 1.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA013341, CAB022293" Enhanced NA NA "Cluster 15: Liver - Metabolism" "Cluster 20: HeLa - Mitochondria" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB022293: , HPA013341: AB_1849509" "unprognostic (1.66e-3)" "unprognostic (1.30e-3)" "unprognostic (4.12e-3)" "unprognostic (1.70e-1)" "unprognostic (2.53e-1)" "unprognostic (2.53e-1)" "prognostic favorable (3.20e-4)" "unprognostic (1.05e-1)" "unprognostic (4.27e-2)" "unprognostic (8.26e-2)" "unprognostic (2.90e-1)" "unprognostic (2.69e-1)" "prognostic unfavorable (5.05e-6)" "unprognostic (7.32e-3)" "unprognostic (2.36e-1)" "unprognostic (1.35e-1)" "unprognostic (5.34e-2)" 1.9 0.8 51.5 0.4 56.0 2.2 1.0 45.4 67.1 3.3 0.0 1.1 0.4 1.2 2.9 9.1 1.2 1.2 4.1 35.8 53.6 2.9 87.3 2.0 0.5 39.4 63.5 2.1 0.3 15.9 3.6 0.8 34.8 2.4 0.5 37.0 0.4 4.0 2.7 1.7 0.9 0.5 43.0 0.7 0.5 4.1 71.3 17.6 0.7 0.8 0.4 0.9 2.6 39.4 0.2 0.2 0.5 0.3 0.4 0.1 0.3 0.2 0.0 0.2 0.3 0.4 0.3 0.4 0.1 0.1 0.5 0.4 0.6 0.2 0.2 0.0 0.5 0.4 1.6 0.8 0.2 0.6 0.6 0.3 0.0 0.0 0.3 0.1 0.1 0.5 0.3 1.0 0.0 0.3 0.2 0.5 0.2 0.3 0.4 0.3 0.0 0.0 0.1 0.5 0.2 0.0 0.2 0.2 0.0 0.3 0.3 0.3 0.1 0.2 0.1 0.2 0.2 0.3 0.1 0.3 0.2 0.5 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 51.5 56.0 45.4 67.1 35.8 53.6 39.4 63.5 34.8 43.0 71.3 39.4 0.3 0.0 0.5 221.0 0.0 0.3 0.0 0.0 6.2 26.6 0.1 0.0 2.1 14.3 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.1 0.0 0.1 2.6 0.0 0.0 3.7 0.0 0.0 1.4 0.0 0.0 2.5 0.2 0.0 25.2 0.0 0.0 332.3 0.0 0.0 0.8 0.0 1.6 5.6 0.2 0.0 108.7 0.0 36.6 0.0 130.2 107.9 0.0 0.0 10.1 0.0 0.0 0.0 0.2 0.0 3.7 13.1 9.4 6.8 3.8 0.1 4.9 0.0 0.0 0.0 0.0 0.0 0.0 SLC6A5 "GLYT2, NET1" ENSG00000165970 "Solute carrier family 6 member 5" Q9Y345 11 20599594-20659285 "Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Neurotransmitter transport, Symport, Transport" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 23 "brain: 22.2" "Group enriched" "Detected in some" 39 "Early spermatids: 20.6;Late spermatids: 66.9" "Not detected" "Not detected" "Group enriched" "Detected in many" 5 "medulla oblongata: 22.2;pons: 20.0;spinal cord: 7.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in some" 9 "pons and medulla: 49.3" "Group enriched" "Detected in many" 8 "medulla oblongata: 30.5;spinal cord: 18.3" CAB079052 Supported NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 31: Spermatids - Spermatogenesis" "CAB079052: " "unprognostic (6.94e-2)" "unprognostic (2.28e-1)" "unprognostic (4.75e-2)" 0.0 0.0 1.2 0.0 0.0 0.0 0.0 1.3 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.9 0.0 22.2 1.3 0.0 0.0 0.0 0.6 0.0 20.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.6 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 1.3 0.2 0.2 0.0 22.2 1.3 20.0 7.6 0.1 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 20.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 66.9 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SLC7A14 "KIAA1613, PPP1R142" ENSG00000013293 "Solute carrier family 7 member 14" Q8TBB6 3 170459548-170586075 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Amino-acid transport, Transport" "Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "brain: 15.9;pituitary gland: 7.3;retina: 6.1" "Group enriched" "Detected in some" 5 "Bipolar cells: 28.4;Excitatory neurons: 61.9;Horizontal cells: 28.6;Inhibitory neurons: 90.2;Oligodendrocytes: 67.4" "Group enriched" "Detected in some" 11 "glioma: 0.8;pancreatic cancer: 0.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "LHCN-M2: 3.2;SCLC-21H: 3.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045929 Approved Approved "Nucleoplasm,Vesicles,Plasma membrane,Cytosol" NA NA "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Vesicles, Cytosol" "Nucleoplasm, Plasma membrane" "HPA045929: AB_2679501" "unprognostic (1.00e-1)" "unprognostic (9.56e-2)" "unprognostic (1.03e-1)" "unprognostic (4.15e-2)" "unprognostic (1.43e-2)" "unprognostic (7.46e-2)" "unprognostic (9.16e-2)" "unprognostic (1.13e-1)" "unprognostic (1.29e-1)" "unprognostic (6.68e-3)" "unprognostic (6.36e-2)" "unprognostic (3.03e-6)" "unprognostic (1.54e-2)" "unprognostic (8.05e-2)" "unprognostic (1.71e-2)" "unprognostic (3.24e-3)" 0.0 2.3 8.9 0.4 8.1 0.1 0.0 5.5 8.8 0.0 0.0 0.5 0.2 0.0 0.0 0.0 0.0 0.1 0.0 7.9 15.9 0.1 0.0 0.0 0.0 15.6 6.4 0.1 0.7 0.0 7.3 0.0 14.9 0.1 0.4 6.1 0.0 0.0 0.1 0.1 0.3 0.1 4.0 0.0 0.2 0.1 8.9 0.0 0.0 0.0 0.0 0.0 0.1 7.7 0.0 0.0 0.1 0.0 0.5 0.9 0.0 0.3 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.8 0.0 0.0 0.5 0.3 0.1 0.0 0.0 0.0 3.2 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.1 0.9 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 8.9 8.1 5.5 8.8 7.9 15.9 15.6 6.4 14.9 4.0 8.9 7.7 0.8 3.2 2.2 4.6 0.1 0.4 0.3 0.1 0.0 28.4 0.1 0.0 1.0 0.0 2.5 0.0 2.1 0.1 0.1 0.0 0.0 0.0 0.6 0.2 0.2 0.5 1.8 0.0 61.9 0.0 0.1 0.4 0.0 0.1 2.5 0.1 0.4 0.9 0.0 28.6 90.2 0.1 0.0 0.0 1.2 0.6 2.1 0.4 3.6 6.5 0.0 1.8 0.0 9.5 67.4 0.1 1.2 2.6 0.1 0.3 0.1 0.2 3.0 4.3 0.0 0.7 0.5 0.0 0.2 0.0 0.6 0.0 0.4 0.1 0.0 0.2 SLC9A1 "APNH, NHE1, PPP1R143" ENSG00000090020 "Solute carrier family 9 member A1" P19634 1 27098809-27166981 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Antiport, Ion transport, Sodium transport, Transport" Calmodulin-binding "Deafness, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "salivary gland: 76.5;stomach 1: 65.9" "Cell type enhanced" "Detected in many" "Distal enterocytes: 81.5;Gastric mucus-secreting cells: 160.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022371, HPA048532, HPA052891" Enhanced Supported "Plasma membrane" NA NA 21000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 15: RT4 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane" "CAB022371: , HPA048532: AB_2680431, HPA052891: AB_2681981" "unprognostic (6.18e-2)" "unprognostic (1.59e-1)" "unprognostic (2.21e-1)" "unprognostic (8.48e-2)" "prognostic unfavorable (7.47e-4)" "unprognostic (2.70e-2)" "unprognostic (4.33e-3)" "unprognostic (3.18e-2)" "unprognostic (9.74e-2)" "prognostic unfavorable (7.10e-4)" "unprognostic (3.44e-2)" "unprognostic (6.95e-2)" "unprognostic (2.05e-2)" "unprognostic (1.27e-2)" "unprognostic (1.60e-1)" "unprognostic (3.34e-1)" "unprognostic (1.16e-2)" 9.6 10.7 6.1 10.4 14.7 11.5 9.0 2.8 10.8 10.9 0.2 18.6 29.3 10.9 8.0 11.0 7.6 16.9 13.7 2.3 5.3 5.8 2.4 13.2 7.0 13.8 4.7 7.0 8.6 20.7 8.2 21.9 11.2 9.0 13.6 4.5 76.5 19.4 4.6 10.5 19.0 10.7 0.5 11.6 65.9 10.1 10.4 6.3 9.5 4.9 6.7 15.1 9.2 2.4 32.3 10.7 9.9 10.1 21.8 15.7 60.8 25.9 38.5 21.7 23.5 13.0 20.0 14.4 21.9 33.4 10.5 38.9 9.8 62.4 13.4 17.4 9.4 21.9 7.1 5.5 66.1 13.1 16.0 19.7 29.5 36.5 50.7 15.8 36.3 9.8 6.3 13.4 32.3 18.7 6.8 6.4 14.0 38.2 21.9 11.8 9.0 6.7 10.9 46.3 11.4 3.7 21.5 28.4 12.6 10.0 13.3 7.9 39.9 23.0 9.4 21.7 14.5 12.6 8.6 4.3 24.6 14.1 13.5 0.0 0.6 0.6 0.7 0.3 1.5 0.1 0.8 0.7 0.2 0.3 0.5 0.6 2.0 0.1 0.6 0.0 0.3 0.8 6.1 14.7 2.8 10.8 2.3 5.3 13.8 4.7 11.2 0.5 10.4 2.4 13.5 6.4 14.8 6.5 7.9 31.2 17.9 14.6 13.1 7.4 21.7 23.2 13.5 7.2 8.3 11.0 0.0 40.3 11.9 81.5 0.0 9.1 26.5 13.8 15.9 9.7 12.5 0.4 14.1 12.5 19.4 12.7 160.0 26.5 27.3 7.5 6.8 1.2 12.9 20.2 14.1 15.0 4.1 5.7 5.1 14.4 9.3 12.7 7.2 8.4 4.3 8.2 12.3 4.0 4.6 28.1 43.1 13.2 4.8 9.6 38.9 1.2 5.9 3.8 6.6 20.8 9.8 3.6 4.4 15.0 25.1 52.9 9.8 4.8 18.3 18.3 SMC1A "DXS423E, KIAA0178, SB1.8, SMC1L1, Smcb" ENSG00000072501 "Structural maintenance of chromosomes 1A" Q14683 X 53374149-53422728 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, DNA damage, DNA repair, Meiosis, Mitosis" "Cancer-related genes, Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005499, CAB025404" Supported Enhanced Nucleoplasm NA NA 33000 "Cluster 27: Non-specific - Gene expression" "Cluster 63: T-cells - Adaptive immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "CAB025404: , HPA005499: AB_1080028" "unprognostic (2.00e-1)" "unprognostic (1.52e-1)" "unprognostic (4.00e-2)" "unprognostic (5.76e-2)" "unprognostic (1.04e-1)" "unprognostic (9.89e-2)" "unprognostic (1.29e-3)" "unprognostic (1.89e-1)" "unprognostic (9.80e-3)" "unprognostic (9.49e-2)" "unprognostic (4.48e-2)" "unprognostic (6.55e-2)" "unprognostic (2.58e-1)" "unprognostic (4.18e-3)" "unprognostic (6.28e-2)" "unprognostic (2.89e-1)" "unprognostic (9.39e-2)" 16.6 11.8 8.7 28.4 11.7 30.3 17.2 15.0 9.5 13.8 9.6 20.0 18.6 21.0 8.0 17.1 16.7 11.5 15.6 7.8 9.5 16.3 18.8 16.0 34.4 10.2 10.7 19.1 14.4 25.8 6.3 18.2 10.7 14.0 18.4 21.0 15.1 13.0 17.9 18.1 15.9 22.9 8.7 20.1 15.7 7.8 11.3 58.1 16.8 18.8 29.9 15.5 12.4 13.9 110.0 115.1 92.4 76.1 32.4 35.4 51.5 68.0 37.0 76.4 59.4 71.6 60.5 115.8 54.1 40.7 105.2 78.9 162.9 92.6 85.1 91.7 176.0 94.3 133.9 51.1 15.4 134.9 120.9 20.6 23.3 86.0 52.8 19.4 67.5 68.7 144.7 64.7 58.6 69.2 122.0 40.8 139.9 47.8 55.6 117.2 165.5 100.1 34.4 69.4 92.8 83.5 176.9 84.4 33.5 122.8 87.9 54.0 45.7 63.3 68.0 65.1 62.2 45.8 77.9 91.9 39.1 152.1 64.1 2.7 6.8 4.5 7.3 8.5 7.6 5.4 5.8 6.7 8.4 5.8 5.2 6.3 2.7 4.6 12.4 4.6 5.7 6.7 8.7 11.7 15.0 9.5 7.8 9.5 10.2 10.7 10.7 8.7 11.3 13.9 40.7 44.8 39.9 16.0 45.6 24.1 37.0 27.7 28.5 46.6 30.7 27.4 63.5 27.1 47.4 20.2 27.1 43.2 57.7 49.6 7.9 31.6 10.5 46.5 62.6 41.7 19.9 70.7 12.0 27.1 61.4 37.2 29.0 44.0 35.4 42.7 18.9 54.1 47.6 60.6 14.2 43.5 22.4 41.1 27.6 7.6 37.9 51.5 23.2 24.4 55.2 38.1 59.8 16.6 30.2 33.1 23.6 36.1 61.2 40.7 29.0 24.6 47.1 48.4 39.5 49.5 71.0 54.5 51.2 39.8 24.4 48.4 47.9 34.0 51.4 32.0 SMN1 "BCD541, GEMIN1, SMA, SMA@, SMA1, SMA2, SMA3, SMNT, TDRD16A" ENSG00000172062 "Survival of motor neuron 1, telomeric" Q16637 5 70925030-70953942 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins" "mRNA processing, mRNA splicing, Neurogenesis" RNA-binding "Disease variant, FDA approved drug targets, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Club cells: 29.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "MOLT-4: 120.5;NB-4: 77.9;T-47d: 88.9;WM-115: 120.3" "CAB016324, HPA045271, CAB069888, HPA073601" Supported Supported "Nuclear bodies,Cytosol" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 72: Non-specific - Transcription" "Cluster 17: WM-115 - Nervous system development" "Cluster 11: Alveolar cells - Smell perception" "Nuclear bodies, Cytosol" "CAB016324: AB_627931, CAB069888: AB_10001257, HPA045271: AB_2679280, HPA073601: " "unprognostic (1.32e-1)" "unprognostic (1.59e-1)" "unprognostic (3.18e-1)" "unprognostic (2.09e-1)" "unprognostic (2.85e-1)" "unprognostic (9.52e-3)" "unprognostic (2.10e-2)" "unprognostic (2.43e-1)" "unprognostic (9.91e-3)" "unprognostic (1.13e-2)" "unprognostic (1.01e-1)" "unprognostic (4.41e-1)" "prognostic unfavorable (6.62e-13)" "unprognostic (2.04e-1)" "unprognostic (2.17e-1)" "unprognostic (8.06e-2)" "unprognostic (4.14e-2)" 28.0 21.8 5.7 4.9 6.1 21.8 26.8 7.6 7.5 33.8 5.0 25.8 2.1 24.7 12.8 25.8 31.5 7.4 20.4 6.3 7.1 22.6 37.6 22.0 15.5 6.5 5.7 36.8 27.6 6.9 26.4 5.1 6.1 25.6 7.8 12.1 21.5 3.8 31.5 24.0 19.6 8.2 5.9 22.6 20.3 24.8 5.7 2.4 24.2 1.5 1.9 26.1 27.6 6.6 11.3 2.1 3.5 4.0 19.3 23.0 62.8 3.5 4.9 5.3 3.8 4.1 4.1 4.6 69.5 9.9 5.8 7.4 5.4 3.7 4.2 1.0 5.2 65.4 6.2 6.2 1.3 7.9 5.8 1.5 29.8 1.8 1.8 31.4 3.0 4.1 2.7 6.4 2.7 3.2 120.5 77.9 4.4 0.9 2.1 6.0 15.9 58.0 2.4 5.2 11.4 16.2 6.5 23.4 69.4 2.4 88.9 21.2 32.7 33.8 3.8 3.1 7.5 4.2 3.0 60.0 4.9 4.8 120.3 9.8 7.4 4.3 6.4 12.2 17.6 13.2 10.2 7.7 11.2 7.2 13.1 14.5 2.1 8.7 13.5 13.1 16.1 6.3 5.7 6.1 7.6 7.5 6.3 7.1 6.5 5.7 6.1 5.9 5.7 6.6 5.0 9.6 11.5 0.0 5.6 13.9 4.6 10.7 0.6 4.7 4.1 4.3 22.4 7.2 29.9 1.8 10.4 7.9 7.0 2.3 5.9 6.8 18.2 5.6 5.5 6.8 6.0 9.9 1.3 4.6 8.4 11.8 4.1 4.4 19.6 4.0 5.0 2.9 4.8 3.3 1.1 4.2 10.2 3.4 4.4 12.9 9.3 5.2 5.4 0.0 6.1 1.4 12.3 1.0 1.3 6.5 1.8 6.4 5.1 2.9 3.8 4.5 28.1 7.8 13.1 7.4 8.5 16.0 17.2 6.9 12.5 8.8 7.2 5.6 4.2 4.1 SMN2 "BCD541, GEMIN1, SMNC, TDRD16B" ENSG00000205571 "Survival of motor neuron 2, centromeric" Q16637 5 70049638-70078522 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins" "mRNA processing, mRNA splicing, Neurogenesis" RNA-binding "Disease variant, FDA approved drug targets, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 41.8;Club cells: 20.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BEWO: 122.7;MOLT-4: 125.1;NB-4: 106.2" "CAB009344, HPA045271, HPA073601" Supported Supported "Nuclear bodies,Cytosol" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 72: Non-specific - Transcription" "Cluster 24: NB-4 - Immune response" "Cluster 43: Cardiomyocytes - Nuclear processes" "Nuclear bodies, Cytosol" "CAB009344: AB_2193083, HPA045271: AB_2679280, HPA073601: " "unprognostic (2.07e-2)" "unprognostic (5.70e-3)" "unprognostic (1.23e-1)" "unprognostic (1.59e-1)" "unprognostic (2.77e-1)" "unprognostic (1.89e-1)" "unprognostic (1.40e-3)" "unprognostic (2.08e-1)" "unprognostic (1.22e-4)" "unprognostic (1.17e-1)" "unprognostic (2.21e-1)" "unprognostic (5.19e-2)" "unprognostic (2.98e-5)" "unprognostic (2.36e-2)" "unprognostic (1.76e-1)" "unprognostic (2.67e-1)" "unprognostic (1.19e-1)" 19.7 15.6 1.6 4.5 1.8 13.8 19.4 1.0 2.3 20.3 1.0 19.2 0.5 20.0 16.9 17.1 15.2 13.6 16.0 1.1 7.2 14.4 23.2 16.4 13.8 1.7 2.0 25.9 18.3 8.4 20.5 3.8 2.0 18.8 5.6 3.0 15.1 5.8 26.0 17.0 13.6 14.0 1.3 14.7 14.5 16.5 1.6 0.1 17.3 0.0 0.1 16.0 20.9 2.3 61.3 0.6 0.6 0.4 16.1 20.9 122.7 31.7 21.1 42.0 44.0 0.4 0.4 1.2 86.6 31.8 1.1 28.8 0.9 0.0 50.1 0.8 1.2 68.6 0.0 2.1 0.0 1.1 0.0 0.3 36.0 0.0 1.1 14.3 0.7 0.0 0.0 0.6 0.0 0.6 125.1 106.2 0.5 0.0 0.5 0.0 45.8 55.3 31.5 0.3 30.5 70.7 60.2 6.7 89.7 0.0 41.4 25.2 53.4 27.2 1.3 0.4 0.7 0.6 1.1 72.4 0.4 0.0 76.2 8.0 9.9 5.2 12.1 16.5 14.6 16.8 14.4 10.1 16.6 20.0 17.0 14.8 1.8 10.9 11.4 16.3 12.7 13.4 1.6 1.8 1.0 2.3 1.1 7.2 1.7 2.0 2.0 1.3 1.6 2.3 2.0 6.4 7.8 0.0 2.7 13.6 3.4 9.7 1.8 0.3 2.7 2.8 41.8 0.0 20.2 1.8 0.0 6.9 4.0 1.1 5.9 2.7 14.1 3.3 4.0 6.6 1.8 3.4 0.0 1.0 3.3 10.1 2.6 3.2 8.2 1.2 2.5 3.1 2.6 1.7 0.0 3.1 6.1 2.6 6.8 8.9 7.2 3.3 1.8 0.0 2.9 0.6 2.1 0.0 0.0 2.3 1.6 5.3 2.5 1.7 2.7 3.8 14.0 1.1 0.0 5.3 6.4 12.0 11.4 3.1 12.6 7.1 5.0 1.0 2.5 2.8 SMPX "Chisel, Csl, DFN6, DFNX4" ENSG00000091482 "Small muscle protein X-linked" Q9UHP9 X 21705978-21758116 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in many" 39 "heart muscle: 757.5;skeletal muscle: 1183.4;tongue: 1097.5" "Cell type enriched" "Detected in some" 22 "Cardiomyocytes: 807.6" "Group enriched" "Detected in many" 4 "head and neck cancer: 7.2;stomach cancer: 1.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "GAMG: 23.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in some" HPA077360 Approved "Plasma membrane" NA NA 62000 "Cluster 13: Striated muscle - Muscle contraction" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 54: Cardiomyocytes - Muscle contraction" "Plasma membrane" "HPA077360: AB_2732342" "unprognostic (7.29e-2)" "unprognostic (1.78e-1)" "unprognostic (2.63e-1)" "unprognostic (1.28e-1)" "unprognostic (1.45e-1)" "prognostic unfavorable (3.04e-5)" "unprognostic (1.39e-2)" "unprognostic (7.46e-2)" "unprognostic (5.27e-1)" "unprognostic (1.96e-2)" "unprognostic (3.97e-2)" "unprognostic (3.58e-2)" "unprognostic (2.67e-2)" "unprognostic (2.82e-1)" "unprognostic (8.38e-2)" 0.2 0.1 2.6 0.5 2.4 0.1 1.1 3.6 3.8 0.3 0.9 25.6 0.7 0.4 0.0 20.0 0.7 0.5 757.5 1.6 4.1 0.1 1.2 0.5 0.2 1.7 3.3 1.1 0.2 0.0 0.2 0.0 1.5 11.1 3.4 1.7 17.8 0.7 1183.4 0.5 4.1 12.6 1.3 0.1 7.2 0.2 5.3 1.5 0.2 1097.5 0.1 3.2 0.2 2.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 23.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.2 0.0 0.0 0.0 4.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.2 0.0 0.0 0.0 0.3 3.4 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 4.6 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 2.4 3.6 3.8 1.6 4.1 1.7 3.3 1.5 1.3 5.3 2.2 0.0 0.0 0.0 0.7 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.1 807.6 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.1 0.0 0.0 0.6 0.0 0.0 16.8 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.0 35.6 9.5 0.1 0.3 0.0 0.0 0.3 0.1 2.1 0.1 0.0 SNAP25 "bA416N4.2, dJ1068F16.2, RIC-4, RIC4, SEC9, SNAP, SNAP-25" ENSG00000132639 "Synaptosome associated protein 25" P60880 20 10218830-10307418 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Transporters" "Congenital myasthenic syndrome, Disease variant, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 20 "brain: 1658.7;retina: 492.0" "Cell type enhanced" "Detected in many" "Bipolar cells: 559.2;Excitatory neurons: 1015.8;Inhibitory neurons: 552.8;Rod photoreceptor cells: 254.4" "Cancer enriched" "Detected in many" 4 "glioma: 28.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "Karpas-707: 23.8;SCLC-21H: 78.2;SH-SY5Y: 46.6;U-87 MG: 56.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000360, HPA001830, HPA071013" Enhanced Supported Approved "Vesicles,Plasma membrane" NA NA 9000 "Cluster 6: Brain - Smell perception" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" Vesicles "CAB000360: AB_2286342, HPA001830: AB_1080039, HPA071013: " "unprognostic (1.64e-3)" "unprognostic (7.26e-3)" "unprognostic (4.36e-2)" "unprognostic (2.49e-7)" "unprognostic (6.86e-3)" "unprognostic (5.87e-3)" "unprognostic (1.15e-2)" "unprognostic (9.94e-2)" "unprognostic (3.13e-1)" "unprognostic (5.82e-3)" "unprognostic (4.80e-3)" "unprognostic (8.06e-2)" "unprognostic (1.09e-1)" "unprognostic (6.18e-3)" "unprognostic (2.48e-1)" "unprognostic (6.28e-3)" "unprognostic (1.02e-2)" 1.5 43.6 251.0 4.1 383.5 0.2 4.4 598.0 1658.7 0.8 0.0 5.7 3.7 7.9 12.9 0.5 7.7 2.3 3.2 420.4 142.2 1.4 1.0 1.8 0.4 427.4 24.7 6.9 6.3 1.2 54.3 0.6 386.6 3.2 2.3 492.0 0.5 19.6 0.8 0.7 3.9 8.1 38.1 0.2 6.3 3.6 147.6 0.5 0.7 0.1 0.4 1.1 1.6 726.9 0.0 4.7 3.9 0.0 0.4 0.1 0.0 2.0 0.0 4.8 1.4 0.0 0.0 0.0 4.3 0.0 3.4 0.8 0.6 0.0 9.6 0.5 0.3 0.0 6.8 0.7 3.5 0.0 0.5 4.4 0.0 3.9 0.0 10.7 0.0 2.8 0.0 23.8 1.6 0.0 0.0 0.0 0.8 3.0 0.0 0.0 0.0 0.1 0.9 0.0 78.2 46.6 0.7 0.1 0.0 2.4 0.0 6.5 0.0 5.0 6.8 0.0 2.3 0.1 12.9 0.1 56.0 0.0 4.7 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 251.0 383.5 598.0 1658.7 420.4 142.2 427.4 24.7 386.6 38.1 147.6 726.9 0.5 0.0 0.0 117.2 0.0 0.8 1.4 0.1 0.0 559.2 0.2 1.3 0.5 8.6 0.0 0.0 106.3 0.0 0.2 0.0 0.0 0.2 16.3 0.1 0.7 5.2 43.5 0.0 1015.8 0.0 0.1 3.9 0.0 0.2 0.0 0.6 0.0 0.2 0.1 65.6 552.8 3.4 0.0 0.0 0.4 83.3 17.1 0.1 1.8 120.9 0.0 71.9 0.0 179.4 113.3 1.0 2.6 68.8 0.0 0.6 0.1 3.0 0.0 254.4 0.0 0.0 1.3 1.1 0.4 0.0 0.9 0.0 0.0 2.6 0.1 0.1 SNCA "NACP, PARK1, PARK4, PD1" ENSG00000145335 "Synuclein alpha" P37840 4 89700345-89838315 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Alzheimer disease, Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 6 "bone marrow: 273.6;brain: 128.2" "Cell type enhanced" "Detected in many" "Erythroid cells: 1225.0;Excitatory neurons: 251.5;Melanocytes: 352.2;Oligodendrocytes: 195.4" "Cancer enriched" "Detected in many" 8 "melanoma: 37.7" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "plasmacytoid DC: 102.9" "Group enriched" "Detected in all" 4 "dendritic cells: 102.9;granulocytes: 51.5;monocytes: 66.9" "Cell line enhanced" "Detected in many" "HEL: 221.5;HUVEC TERT2: 269.8;RT4: 137.3;SK-MEL-30: 271.6;TIME: 311.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005459, CAB010877" Enhanced "Intracellular and membrane" NA NA 28000000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 6: Erythroid cells - Oxygen transport" "CAB010877: AB_261518, HPA005459: AB_2667324" "unprognostic (4.80e-2)" "unprognostic (1.52e-1)" "unprognostic (8.13e-2)" "unprognostic (1.05e-3)" "unprognostic (2.65e-2)" "unprognostic (1.54e-2)" "unprognostic (1.78e-2)" "unprognostic (3.44e-2)" "unprognostic (1.73e-2)" "unprognostic (3.85e-3)" "unprognostic (1.01e-3)" "unprognostic (2.09e-2)" "unprognostic (1.57e-1)" "unprognostic (2.51e-3)" "unprognostic (1.68e-1)" "unprognostic (3.93e-4)" "unprognostic (7.48e-3)" 16.0 9.9 91.5 10.0 112.2 273.6 7.8 47.2 128.2 26.1 16.1 28.5 3.3 34.3 3.4 8.5 11.2 5.4 20.9 115.2 69.1 12.4 2.9 16.6 2.2 97.5 88.3 29.3 2.2 1.1 28.7 28.3 89.9 17.3 6.9 20.3 15.9 9.7 1.2 16.4 8.6 33.3 36.0 15.2 6.4 3.2 76.2 5.3 10.2 8.5 4.8 9.3 23.2 107.0 0.5 1.0 40.1 0.0 0.7 0.0 0.6 0.4 44.5 1.6 3.0 0.0 0.0 0.2 12.0 0.0 0.0 9.3 53.6 97.7 1.5 0.0 22.6 221.5 115.4 0.5 84.2 0.0 1.4 2.1 38.2 0.0 109.5 117.3 269.8 2.2 2.0 0.6 0.2 0.0 2.1 0.3 10.6 0.2 4.8 0.0 15.8 0.0 0.3 137.3 23.2 15.6 0.2 0.3 271.6 29.0 0.0 0.4 311.4 1.3 8.0 0.1 0.8 0.2 0.2 0.1 8.8 0.2 87.4 51.5 66.9 0.1 0.3 27.7 0.1 4.2 1.9 0.3 84.6 1.7 1.0 0.5 11.1 17.3 8.2 102.9 0.0 63.7 91.5 112.2 47.2 128.2 115.2 69.1 97.5 88.3 89.9 36.0 76.2 107.0 1.8 0.0 0.6 40.1 2.6 76.6 16.3 173.4 101.3 10.4 0.9 14.4 13.4 0.0 21.5 11.0 0.0 10.1 10.1 0.1 1.9 0.0 0.6 0.3 1.1 19.4 1.8 1225.0 251.5 0.2 1.9 32.7 0.0 0.3 0.0 23.9 7.5 0.8 62.3 10.1 53.8 0.0 44.7 17.2 64.2 1.5 2.1 100.7 352.2 76.8 24.4 19.4 4.1 95.5 195.4 0.2 0.0 0.0 0.5 11.3 0.0 2.0 6.6 7.4 13.1 0.5 5.3 19.6 16.9 4.5 22.6 3.4 3.8 43.6 0.0 3.4 SNCB ENSG00000074317 "Synuclein beta" Q16143 5 176620082-176630556 "Human disease related genes, Predicted intracellular proteins, Transporters" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 18 "brain: 439.2;retina: 182.2" "Cell type enhanced" "Detected in some" "Bipolar cells: 105.1;Excitatory neurons: 36.8;Horizontal cells: 50.5;Inhibitory neurons: 32.6;Rod photoreceptor cells: 49.7" "Cancer enriched" "Detected in some" 8 "glioma: 11.1" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 9 "SCLC-21H: 54.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002681, HPA035876" Enhanced Supported NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 58: Brain - Synaptic function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 56: Bipolar cells - Visual perception" "CAB002681: , HPA035876: AB_10670592" "unprognostic (3.55e-2)" "unprognostic (1.05e-1)" "unprognostic (4.79e-2)" "unprognostic (1.46e-2)" "unprognostic (3.41e-3)" "unprognostic (2.95e-2)" "unprognostic (6.07e-2)" "unprognostic (3.41e-1)" "unprognostic (2.39e-1)" "unprognostic (2.29e-3)" "unprognostic (3.31e-1)" "unprognostic (5.41e-5)" "unprognostic (1.31e-3)" "unprognostic (8.57e-2)" "unprognostic (2.81e-1)" "unprognostic (8.42e-3)" 0.1 3.2 81.7 0.0 154.5 0.0 0.1 74.3 439.2 0.1 0.0 1.0 0.1 0.1 0.0 0.1 0.0 0.0 1.5 136.3 41.9 0.1 0.2 0.2 0.2 104.2 23.8 0.3 0.8 0.0 17.1 0.0 77.7 0.1 0.0 182.2 0.1 0.0 1.9 0.3 0.4 0.0 1.3 0.2 0.3 0.6 63.1 0.0 0.2 2.8 0.0 0.1 0.1 237.7 0.0 0.0 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.8 0.7 0.0 6.0 0.3 2.7 0.4 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.3 1.8 1.0 0.0 0.0 3.9 0.0 2.3 0.0 0.0 0.3 0.0 0.0 54.6 2.0 0.0 0.2 5.4 0.1 2.5 0.3 0.0 0.0 2.2 0.0 0.0 0.7 0.0 0.1 0.6 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 81.7 154.5 74.3 439.2 136.3 41.9 104.2 23.8 77.7 1.3 63.1 237.7 0.0 0.0 0.0 3.9 0.0 0.0 0.0 0.0 0.0 105.1 0.0 0.0 1.5 0.0 0.0 0.0 16.7 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.3 0.0 0.0 36.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 50.5 32.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 7.5 0.0 10.3 0.0 3.5 6.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 49.7 0.0 0.0 0.1 0.1 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SNRNP200 "ASCC3L1, BRR2, HELIC2, KIAA0788, RP33, U5-200KD" ENSG00000144028 "Small nuclear ribonucleoprotein U5 subunit 200" O75643 2 96274338-96321271 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "mRNA processing, mRNA splicing" "Helicase, Hydrolase" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029321 Approved Supported Nucleoplasm NA NA 78000 "Cluster 41: Basophils - Cellular respiration" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 24: Non-specific - Transcription regulation" Nucleoplasm "HPA029321: AB_10604096" "unprognostic (2.63e-2)" "unprognostic (1.45e-1)" "unprognostic (1.44e-1)" "prognostic unfavorable (3.89e-4)" "unprognostic (1.50e-1)" "unprognostic (1.09e-1)" "unprognostic (2.48e-3)" "unprognostic (1.01e-1)" "unprognostic (1.75e-1)" "unprognostic (1.74e-1)" "unprognostic (3.10e-1)" "unprognostic (6.46e-2)" "unprognostic (2.61e-2)" "unprognostic (1.82e-1)" "unprognostic (2.69e-1)" "unprognostic (1.50e-1)" "unprognostic (1.03e-1)" 26.5 21.8 11.2 38.1 11.3 58.8 38.6 16.9 12.1 31.9 25.5 29.6 29.4 41.0 20.2 29.5 39.8 25.8 26.9 9.9 11.1 28.8 29.3 29.3 43.2 13.1 10.3 53.2 34.3 52.4 19.7 39.2 12.0 31.6 34.6 67.6 35.1 33.0 47.4 30.8 30.3 38.5 12.2 36.5 30.6 40.4 9.8 73.5 37.4 38.7 52.3 30.1 21.6 14.6 97.8 107.7 144.1 106.1 63.1 57.1 131.5 67.3 80.6 119.5 112.9 197.3 69.3 169.3 101.3 83.3 178.9 74.9 264.4 88.8 130.8 94.3 139.4 221.6 169.8 106.7 40.9 171.2 92.4 58.1 53.7 133.2 112.0 61.3 97.3 98.3 198.2 112.3 68.3 82.3 158.8 49.4 182.8 77.9 102.4 185.0 139.3 107.4 43.8 145.4 159.8 150.5 107.7 88.7 65.4 165.0 86.4 100.5 86.2 98.3 117.2 101.3 96.2 101.0 134.0 207.6 66.2 109.0 106.2 16.7 4.7 6.0 7.9 5.0 8.9 5.7 6.0 9.5 5.6 6.1 5.2 7.1 4.7 7.3 6.1 5.8 6.8 5.5 11.2 11.3 16.9 12.1 9.9 11.1 13.1 10.3 12.0 12.2 9.8 14.6 47.3 44.8 53.9 21.9 57.4 29.6 27.2 35.5 38.1 79.3 40.2 42.4 35.2 54.3 46.2 51.5 104.3 43.2 64.2 43.4 5.9 42.6 29.3 42.4 48.7 44.8 46.7 54.1 21.2 46.7 36.1 37.9 52.0 48.8 25.3 79.0 40.4 49.4 35.1 87.5 21.1 40.6 34.6 31.9 33.2 18.2 57.5 35.2 17.8 16.9 45.2 79.1 73.2 17.1 16.7 46.1 30.7 55.3 68.3 34.8 47.3 17.9 50.7 135.2 65.7 54.7 45.5 77.6 56.0 38.7 33.0 44.6 71.6 53.3 49.4 30.3 SNX14 RGS-PX2 ENSG00000135317 "Sorting nexin 14" Q9Y5W7 6 85505496-85594156 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Protein transport, Transport" "Disease variant, Mental retardation, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 173.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017639 Approved Supported Vesicles,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 68: Epididymis - Unknown function" "Cluster 32: U-937 - Innate immune response" "Cluster 66: Spermatocytes - Spermatogenesis" "Vesicles, Cytosol" "HPA017639: AB_1857345" "unprognostic (1.16e-2)" "unprognostic (3.29e-2)" "unprognostic (2.19e-2)" "unprognostic (1.52e-2)" "unprognostic (5.23e-2)" "prognostic unfavorable (2.78e-4)" "unprognostic (1.92e-2)" "unprognostic (3.45e-2)" "unprognostic (4.60e-1)" "unprognostic (1.57e-2)" "unprognostic (3.14e-2)" "unprognostic (2.37e-2)" "unprognostic (1.10e-3)" "unprognostic (1.02e-1)" "unprognostic (1.38e-1)" "unprognostic (1.87e-3)" "unprognostic (4.72e-3)" 27.3 39.9 39.0 23.0 40.5 31.4 41.7 44.4 61.0 30.8 49.7 39.7 29.8 23.5 57.3 24.3 28.2 28.3 24.8 40.7 47.0 54.4 69.6 39.6 32.6 40.1 40.7 26.8 43.6 47.1 36.3 36.2 43.1 33.2 35.1 47.2 27.8 30.8 16.4 28.6 31.7 22.4 40.9 37.4 45.3 87.0 42.5 18.9 40.5 12.9 28.8 35.1 24.7 44.2 46.1 27.3 44.5 64.9 98.3 71.6 46.0 58.0 78.5 44.2 67.5 49.0 75.4 60.3 69.8 74.4 85.9 60.7 30.5 58.8 69.4 53.3 18.0 66.1 36.4 75.1 80.9 62.4 65.0 63.0 43.7 52.0 51.6 81.1 79.4 23.2 67.7 50.4 96.9 52.1 4.4 117.0 18.3 72.1 31.1 26.2 90.6 29.1 107.1 82.7 19.8 44.5 35.0 76.6 56.3 57.9 47.9 108.9 71.6 35.4 21.8 44.1 60.3 50.4 87.0 22.8 71.3 72.2 71.8 36.7 21.5 33.0 19.9 33.6 14.7 13.3 13.4 18.1 26.2 14.7 12.0 15.0 9.9 22.9 40.9 7.9 16.7 15.7 39.0 40.5 44.4 61.0 40.7 47.0 40.1 40.7 43.1 40.9 42.5 44.2 28.5 93.0 47.2 76.4 25.3 14.7 18.7 32.8 15.9 36.4 23.3 15.1 16.9 15.7 39.1 22.0 56.3 50.4 32.6 30.7 5.9 31.7 87.1 37.3 22.2 26.9 31.8 13.2 115.2 41.6 31.9 23.1 37.8 32.5 31.6 36.0 26.0 28.7 35.4 15.2 124.4 26.1 65.1 37.7 22.3 21.6 19.6 33.4 28.4 63.7 43.1 26.1 41.2 85.5 91.0 34.4 22.0 29.3 23.8 15.7 31.9 25.1 58.9 40.7 19.7 26.2 33.0 173.0 14.9 15.9 14.8 56.5 26.4 26.5 28.6 17.7 SOD1 "ALS, ALS1, IPOA" ENSG00000142168 "Superoxide dismutase 1" P00441 21 31659666-31668931 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Antioxidant, Oxidoreductase" "Amyotrophic lateral sclerosis, Cancer-related genes, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 1645.6" "Cell type enhanced" "Detected in all" "Hepatocytes: 3357.9;Proximal tubular cells: 3285.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001401, CAB008670" Enhanced Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA 44900000 50000000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 15: Liver - Metabolism" "Cluster 16: U-266 - Nucleosome" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nucleoplasm, Plasma membrane, Cytosol" "CAB008670: AB_1623312, HPA001401: AB_1080132" "unprognostic (1.73e-1)" "unprognostic (1.18e-2)" "unprognostic (4.43e-1)" "unprognostic (6.19e-2)" "unprognostic (1.39e-1)" "unprognostic (9.59e-3)" "unprognostic (8.34e-2)" "unprognostic (2.30e-1)" "unprognostic (3.47e-1)" "unprognostic (5.28e-2)" "unprognostic (9.33e-2)" "unprognostic (1.96e-1)" "unprognostic (1.03e-2)" "unprognostic (1.66e-1)" "unprognostic (1.74e-2)" "unprognostic (1.57e-1)" "unprognostic (3.26e-2)" 257.6 597.1 558.0 118.4 577.4 166.4 233.5 605.2 805.1 206.6 586.6 251.0 360.3 179.5 228.4 221.1 197.1 206.0 477.3 575.1 619.9 483.2 1645.6 153.9 169.6 619.8 604.6 302.1 117.1 210.6 236.7 155.8 653.1 203.9 180.5 248.6 160.5 204.2 428.0 152.1 266.7 136.6 588.1 147.5 210.4 132.1 585.8 165.7 197.4 355.9 151.7 232.1 220.6 634.7 526.8 451.4 309.2 312.8 407.3 282.1 257.8 430.2 258.0 291.3 217.4 593.6 326.0 628.2 441.2 405.8 517.7 186.1 453.3 320.6 239.9 463.3 540.0 1008.2 579.5 866.3 267.4 451.7 363.1 294.8 240.6 406.5 225.2 327.9 331.2 469.0 704.4 773.2 357.4 860.0 489.0 454.5 466.1 830.0 475.4 413.0 622.0 981.4 579.4 320.5 335.9 281.4 805.1 419.4 438.3 279.2 484.3 393.4 387.4 222.9 489.2 304.7 322.0 583.4 1374.2 741.8 455.7 654.3 301.9 204.2 159.7 194.0 313.4 234.0 365.3 427.1 509.2 402.4 212.8 310.1 521.8 412.1 37.8 241.4 465.4 240.6 746.0 474.5 558.0 577.4 605.2 805.1 575.1 619.9 619.8 604.6 653.1 588.1 585.8 634.7 319.8 294.9 175.1 38.2 248.1 491.4 672.7 479.2 319.8 226.6 264.1 352.9 721.0 527.6 294.7 391.8 47.9 703.4 250.2 703.5 1631.7 426.3 277.0 410.7 241.2 261.0 288.4 898.8 39.7 807.3 574.9 365.8 198.8 216.3 220.0 278.9 318.1 3357.9 363.3 282.7 45.5 402.7 366.2 220.0 318.5 952.2 521.9 224.2 419.8 29.0 313.1 598.5 239.0 28.6 68.7 322.8 600.9 528.1 178.2 567.0 1158.3 3285.9 638.3 216.5 440.4 313.6 404.5 211.7 506.3 379.9 349.8 725.9 423.1 470.3 593.6 497.7 SPART "KIAA0610, SPG20, TAHCCP1" ENSG00000133104 Spartin Q8N0X7 13 36301638-36370180 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Granulosa cells: 75.0;Proximal tubular cells: 90.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 5 "basophil: 172.7" "Lineage enriched" "Detected in all" 7 "granulocytes: 172.7" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039053, HPA039054" Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 68: Epididymis - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" Cytosol "Plasma membrane" "HPA039053: AB_10672769, HPA039054: AB_2676323" "unprognostic (3.73e-2)" "unprognostic (9.39e-2)" "unprognostic (3.06e-2)" "unprognostic (4.60e-2)" "unprognostic (2.21e-2)" "unprognostic (1.10e-2)" "unprognostic (9.18e-3)" "unprognostic (9.58e-2)" "unprognostic (3.36e-2)" "unprognostic (2.22e-1)" "unprognostic (7.62e-2)" "unprognostic (8.14e-2)" "unprognostic (1.54e-1)" "unprognostic (9.26e-2)" "unprognostic (1.22e-1)" "unprognostic (1.54e-2)" "unprognostic (5.79e-2)" 42.3 48.4 36.9 18.0 42.8 23.6 32.5 43.4 50.6 49.2 42.3 37.8 12.7 42.4 67.1 24.5 44.5 37.4 25.7 35.3 39.4 48.4 19.9 27.0 15.7 42.4 40.5 63.6 14.6 29.5 29.6 39.8 42.1 34.7 13.3 43.3 17.3 36.4 33.5 18.4 15.4 52.8 41.2 30.7 21.1 27.6 38.3 16.7 35.6 33.7 11.2 35.5 29.9 51.0 0.1 22.4 59.5 0.0 127.9 106.6 42.4 54.1 81.3 53.7 52.8 0.1 0.0 0.0 32.9 65.9 98.2 31.2 81.4 38.0 57.5 4.4 46.9 69.4 28.3 14.6 128.0 72.8 134.3 106.2 59.5 44.4 61.9 131.7 79.6 18.7 30.6 11.9 97.5 5.2 21.7 120.8 30.0 0.0 7.8 0.0 99.4 2.5 62.5 28.2 6.2 14.5 46.3 18.3 58.9 85.3 10.5 84.7 66.8 40.0 20.1 55.9 32.2 14.2 0.2 0.1 44.6 61.8 71.0 172.7 22.1 30.1 13.5 21.7 13.1 10.1 18.6 5.4 15.7 9.7 24.5 13.1 35.0 14.2 23.8 19.3 4.8 18.1 36.9 42.8 43.4 50.6 35.3 39.4 42.4 40.5 42.1 41.2 38.3 51.0 43.5 35.3 51.5 0.0 6.1 0.0 0.0 0.0 0.0 0.0 30.8 30.1 0.0 0.0 40.2 27.6 0.0 52.7 18.6 0.0 66.5 26.2 0.0 59.4 62.6 15.9 0.0 0.0 0.0 15.0 59.7 39.8 0.0 38.1 58.0 75.0 0.0 0.0 42.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 24.0 0.0 0.0 24.3 0.0 0.0 0.0 0.0 16.8 0.0 0.0 3.5 0.0 0.0 90.4 65.6 0.0 0.0 0.0 27.8 0.0 0.0 0.0 0.0 64.3 10.8 59.2 0.0 0.0 SPAST "ADPSP, FSP2, KIAA1083, SPG4" ENSG00000021574 Spastin Q9UBP0 2 32063556-32157637 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Cell cycle, Cell division, Differentiation, Neurogenesis" "Allosteric enzyme, Developmental protein, Isomerase" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Inhibitory neurons: 55.2;Oligodendrocyte precursor cells: 59.3;Oligodendrocytes: 62.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017311 Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 24: NB-4 - Immune response" "Cluster 44: Endometrium - Transcription" Nucleoplasm Cytosol "HPA017311: AB_1857415" "unprognostic (1.89e-1)" "unprognostic (1.59e-2)" "unprognostic (5.33e-2)" "unprognostic (3.90e-2)" "unprognostic (3.75e-2)" "unprognostic (4.00e-2)" "prognostic unfavorable (1.62e-4)" "unprognostic (3.26e-2)" "unprognostic (2.35e-2)" "unprognostic (7.39e-2)" "unprognostic (5.98e-2)" "unprognostic (3.52e-1)" "prognostic unfavorable (4.15e-4)" "unprognostic (5.71e-2)" "unprognostic (3.04e-1)" "unprognostic (1.53e-2)" "unprognostic (1.13e-1)" 5.8 5.9 9.0 7.2 12.7 9.9 6.2 10.8 12.9 8.6 1.6 7.1 7.4 7.7 5.0 6.9 6.5 6.5 3.9 9.0 10.6 5.9 9.6 6.3 9.7 10.8 11.2 9.1 5.3 6.2 4.4 6.8 10.5 6.3 7.5 6.9 4.2 5.3 7.8 7.4 8.0 7.3 11.6 7.0 6.3 9.8 10.7 14.1 8.5 10.0 9.2 7.3 4.4 13.9 17.5 12.2 19.7 19.5 12.0 14.2 17.8 9.4 13.7 9.7 8.6 16.9 14.8 30.2 8.5 13.1 14.2 12.0 19.5 9.6 11.9 20.7 11.8 33.3 6.0 20.5 11.0 23.2 22.4 7.9 12.3 12.4 11.6 11.7 21.5 9.6 27.6 10.0 10.7 7.4 37.8 19.4 20.5 19.2 7.1 19.8 27.9 19.5 13.0 10.7 27.9 29.9 16.0 13.2 15.9 16.0 8.7 15.8 18.8 10.6 16.2 9.5 11.1 14.7 29.7 23.8 11.6 19.9 13.0 1.8 3.5 3.8 1.8 4.9 2.5 2.4 2.8 2.9 3.9 1.9 2.9 3.0 5.3 3.9 3.8 1.7 4.2 2.5 9.0 12.7 10.8 12.9 9.0 10.6 10.8 11.2 10.5 11.6 10.7 13.9 15.0 9.6 4.4 26.4 12.2 9.6 5.9 7.9 11.4 15.4 11.7 6.9 8.0 8.6 7.9 5.5 22.9 9.6 21.4 11.4 0.0 6.6 4.4 16.9 11.8 11.3 10.8 10.3 38.9 8.0 7.4 8.1 9.7 13.7 10.1 16.7 7.9 12.0 9.7 10.1 55.2 10.8 10.2 17.5 9.9 8.5 8.7 17.6 1.8 36.5 21.1 7.9 18.6 59.3 62.7 10.4 9.8 10.1 12.5 8.7 10.9 7.0 13.0 14.1 0.0 11.9 11.9 16.7 21.2 11.7 13.1 8.1 13.3 10.9 10.4 7.2 SPATA5 "AFG2, SPAF" ENSG00000145375 "Spermatogenesis associated 5" Q8NB90 4 122923070-123319433 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Differentiation, Spermatogenesis" "Chaperone, Developmental protein, Hydrolase" "Deafness, Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Early spermatids: 207.9;Inhibitory neurons: 59.0;Microglial cells: 104.0;Oligodendrocyte precursor cells: 79.9;Oligodendrocytes: 91.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036450, HPA036451" Approved Approved Cytosol NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 23: Spermatids - Flagellum & Golgi organization" Cytosol "HPA036450: AB_2675131, HPA036451: AB_10670107" "unprognostic (4.28e-1)" "unprognostic (7.54e-2)" "unprognostic (7.37e-3)" "unprognostic (1.26e-1)" "unprognostic (5.16e-1)" "unprognostic (1.18e-1)" "unprognostic (7.65e-4)" "unprognostic (1.95e-3)" "unprognostic (9.00e-2)" "unprognostic (2.78e-1)" "unprognostic (4.43e-3)" "unprognostic (4.62e-2)" "unprognostic (1.26e-2)" "unprognostic (1.52e-1)" "unprognostic (5.68e-1)" "unprognostic (2.63e-2)" "unprognostic (1.79e-1)" 1.3 0.8 0.8 0.9 1.1 1.4 1.6 2.3 1.0 1.3 1.2 1.0 0.6 1.3 0.8 1.0 1.0 0.8 0.9 0.6 1.2 1.1 1.1 0.9 1.2 1.2 1.1 1.2 0.8 1.5 0.7 1.4 1.2 1.1 1.2 2.2 1.0 1.1 1.3 1.2 0.7 1.3 1.0 1.3 2.3 3.6 1.0 2.0 1.5 1.2 1.2 1.0 1.1 1.3 2.3 3.2 2.9 7.1 2.4 1.7 1.9 4.0 1.6 3.3 3.3 1.5 3.2 3.7 2.4 2.4 2.4 2.0 5.0 2.2 5.6 6.2 0.9 3.8 5.7 2.5 1.1 5.2 4.0 1.2 1.1 3.8 3.3 1.7 3.4 2.4 7.7 6.2 4.6 2.4 10.1 3.2 2.1 3.6 1.3 3.3 7.2 2.4 1.9 1.9 4.8 3.1 3.2 2.3 1.7 4.2 2.2 2.0 2.6 6.9 5.2 4.6 4.2 3.9 5.0 3.3 3.3 4.4 6.2 0.5 0.2 0.2 0.6 0.6 0.4 0.5 0.5 0.5 0.1 0.5 0.5 0.5 0.3 0.5 0.2 0.7 0.3 0.2 0.8 1.1 2.3 1.0 0.6 1.2 1.2 1.1 1.2 1.0 1.0 1.3 10.7 16.0 5.0 34.6 9.1 5.1 5.6 2.6 6.2 6.2 4.2 3.2 4.3 11.5 7.4 1.8 14.6 5.1 6.7 2.9 0.0 3.1 207.9 4.5 9.6 8.5 2.4 11.2 48.8 3.6 4.3 5.1 14.3 5.2 5.1 8.6 4.2 3.2 3.5 3.3 59.0 2.6 0.0 4.1 5.3 25.0 7.2 5.3 0.0 104.0 1.8 4.0 4.1 79.9 91.4 4.2 2.1 4.5 10.6 3.9 1.5 3.1 6.4 11.3 0.0 12.5 6.6 14.7 10.6 5.0 5.4 2.2 9.9 4.7 4.1 3.0 SPATA7 "HSD3, LCA3" ENSG00000042317 "Spermatogenesis associated 7" Q9P0W8 14 88384924-88470350 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Sensory transduction, Vision" "Leber congenital amaurosis, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 57.0" "Group enriched" "Detected in many" 9 "Early spermatids: 946.9;Late spermatids: 1152.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038082, HPA038083" Enhanced Approved Nucleoplasm,Mitochondria,Cytosol NA NA "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 34: Spermatids - Unknown function" "Nucleoplasm, Mitochondria, Cytosol" "HPA038082: AB_10671738, HPA038083: AB_10671519" "unprognostic (2.09e-2)" "unprognostic (6.72e-2)" "unprognostic (1.10e-1)" "unprognostic (6.50e-3)" "unprognostic (3.22e-2)" "unprognostic (6.75e-2)" "unprognostic (1.29e-3)" "unprognostic (4.70e-2)" "unprognostic (1.70e-1)" "unprognostic (5.45e-3)" "prognostic favorable (4.16e-5)" "unprognostic (2.88e-1)" "prognostic favorable (2.50e-5)" "unprognostic (8.41e-2)" "unprognostic (1.29e-2)" "unprognostic (6.09e-2)" "unprognostic (2.81e-2)" 5.8 6.0 8.6 1.6 10.4 1.7 6.0 28.4 9.5 7.2 6.7 5.8 2.2 6.6 7.0 2.8 8.3 5.5 5.4 8.6 10.4 9.5 5.1 4.6 1.8 8.6 9.2 12.3 7.9 7.6 11.1 2.8 8.6 6.6 3.1 10.2 4.1 4.6 5.0 5.6 3.2 4.7 8.9 3.6 5.0 57.0 9.2 3.0 12.1 4.5 1.2 5.4 4.9 11.2 2.3 3.7 5.5 7.5 8.8 16.5 6.0 5.2 9.3 5.1 3.4 1.2 4.5 2.2 2.5 5.7 3.8 2.3 2.5 4.0 4.8 3.2 1.8 0.5 1.9 2.1 12.7 3.9 0.5 7.8 6.6 2.1 3.9 16.8 9.4 5.0 1.3 2.7 4.8 2.8 2.8 3.7 1.4 2.9 4.6 3.9 5.6 1.3 8.1 1.9 3.9 4.9 5.1 6.7 5.0 6.5 6.0 4.2 4.9 3.7 4.0 5.2 2.9 2.6 2.1 1.3 6.2 1.1 2.6 0.0 1.0 0.2 2.1 1.4 2.5 1.9 1.7 1.0 2.1 0.4 1.0 1.8 0.8 0.4 0.9 2.1 0.7 1.0 8.6 10.4 28.4 9.5 8.6 10.4 8.6 9.2 8.6 8.9 9.2 11.2 7.8 12.8 7.3 38.5 1.5 2.4 7.6 9.8 7.4 10.8 6.3 8.5 12.0 7.2 8.8 3.7 20.9 2.6 5.3 1.1 9.8 11.0 946.9 22.3 13.2 6.8 16.3 1.3 113.0 7.2 3.6 11.8 4.1 4.2 1.3 19.4 7.9 4.5 5.7 15.2 91.6 4.0 12.2 17.2 2.8 1152.6 20.5 6.7 8.8 25.3 4.0 12.5 2.1 49.8 54.7 5.6 4.3 17.0 0.9 3.0 1.4 26.0 32.7 20.5 6.6 15.0 7.9 37.5 14.7 3.0 2.0 1.1 3.3 20.5 4.5 3.3 SPG11 "ALS5, FLJ21439, KIAA1840" ENSG00000104133 "SPG11 vesicle trafficking associated, spatacsin" Q96JI7 15 44562696-44663678 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Amyotrophic lateral sclerosis, Charcot-Marie-Tooth disease, Hereditary spastic paraplegia, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 121.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040412, HPA040947" Approved Supported "Nucleoli,Plasma membrane,Cytosol" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 18: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 52: Non-specific - Transcription" "Plasma membrane, Cytosol" Nucleoli "HPA040412: AB_10795418, HPA040947: AB_10796232" "unprognostic (1.10e-1)" "unprognostic (1.74e-1)" "unprognostic (2.39e-1)" "unprognostic (1.98e-3)" "unprognostic (1.99e-1)" "unprognostic (9.31e-2)" "unprognostic (2.91e-1)" "unprognostic (2.32e-1)" "unprognostic (6.71e-2)" "unprognostic (2.26e-3)" "unprognostic (2.58e-2)" "unprognostic (9.19e-2)" "prognostic favorable (6.28e-5)" "unprognostic (8.73e-2)" "unprognostic (2.48e-1)" "unprognostic (3.72e-1)" "unprognostic (6.06e-2)" 21.1 27.1 18.4 18.2 25.7 27.4 21.6 24.4 21.3 21.5 23.9 25.6 17.1 17.9 25.3 25.6 20.2 16.1 25.5 17.5 22.2 25.0 29.8 24.8 28.4 23.8 22.1 21.4 28.6 26.7 21.3 14.9 23.9 25.3 19.9 30.5 24.7 15.0 22.9 30.4 30.1 12.7 19.1 43.0 26.0 25.5 24.6 23.7 30.9 14.3 18.6 23.8 22.6 33.4 13.2 8.8 21.9 21.6 33.7 33.0 15.8 13.4 17.4 13.0 16.6 10.8 12.5 9.7 16.5 18.2 22.5 29.0 15.1 20.8 12.5 29.3 9.0 22.1 21.1 16.4 23.7 22.2 19.2 25.3 23.3 10.7 30.5 20.4 18.6 16.6 28.8 24.2 18.6 11.5 10.1 19.7 11.5 40.3 11.6 12.9 18.5 10.6 28.0 33.6 14.2 16.8 14.6 23.3 13.1 18.0 22.0 30.2 19.9 17.1 8.5 21.4 16.5 23.8 22.6 19.2 17.6 28.8 17.9 5.7 7.7 11.8 6.5 9.2 6.9 10.0 5.4 4.9 6.2 11.3 4.3 5.3 11.6 6.2 12.4 6.3 6.1 3.7 18.4 25.7 24.4 21.3 17.5 22.2 23.8 22.1 23.9 19.1 24.6 33.4 21.0 44.8 22.2 56.2 40.4 9.3 15.6 18.8 14.2 25.1 19.0 12.6 20.1 18.6 31.3 27.6 47.9 16.5 30.1 29.3 5.9 21.3 28.2 31.7 23.2 17.6 20.0 22.3 62.9 16.9 10.1 19.3 37.2 33.6 27.3 31.9 21.8 23.5 20.1 16.8 68.1 31.2 26.4 43.3 23.5 33.2 17.7 40.4 14.2 74.9 88.1 14.0 50.4 68.3 121.4 17.7 24.0 13.9 21.4 19.3 30.8 14.9 53.6 21.7 6.6 24.8 16.3 51.7 31.6 20.1 11.1 9.3 29.5 24.4 27.3 22.2 SPG21 "ABHD21, ACP33, BM-019, GL010, MAST" ENSG00000090487 "SPG21 abhydrolase domain containing, maspardin" Q9NZD8 15 64963022-64990310 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 181.4" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040407, HPA040436" Approved Supported Vesicles,Cytosol NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "Vesicles, Cytosol" "HPA040407: AB_2676965, HPA040436: AB_10796454" "unprognostic (7.47e-2)" "unprognostic (2.94e-2)" "unprognostic (5.81e-2)" "unprognostic (2.98e-1)" "unprognostic (1.64e-1)" "unprognostic (5.40e-3)" "unprognostic (7.25e-2)" "unprognostic (1.43e-1)" "unprognostic (4.19e-2)" "unprognostic (8.07e-2)" "unprognostic (4.24e-3)" "unprognostic (1.15e-1)" "unprognostic (3.96e-1)" "unprognostic (1.55e-1)" "unprognostic (3.49e-1)" "unprognostic (2.57e-1)" "unprognostic (3.19e-1)" 56.6 61.7 48.4 50.8 54.1 69.4 68.8 51.5 52.9 60.4 66.0 61.6 52.1 60.2 150.1 46.1 73.4 54.7 54.4 47.8 50.3 85.3 113.1 61.9 56.9 52.1 50.2 55.3 54.7 72.1 47.1 66.3 52.7 49.8 59.3 38.6 45.7 59.0 74.3 58.5 46.6 64.5 51.1 52.6 60.1 35.0 52.6 57.7 83.1 42.4 58.8 61.2 47.8 59.4 87.0 127.0 62.8 119.5 158.7 155.7 78.0 52.8 179.7 103.2 119.8 57.4 131.1 99.1 80.6 124.8 153.1 113.3 182.1 124.5 97.8 41.0 58.5 85.7 81.7 104.0 200.7 82.2 72.7 107.0 139.3 82.1 154.2 100.7 125.6 112.2 72.7 78.3 127.8 124.1 75.8 71.5 69.6 193.9 66.3 78.2 67.3 174.6 107.1 103.6 76.7 68.6 62.7 131.4 124.9 123.3 89.9 140.9 61.5 87.1 90.6 125.4 80.6 55.6 101.8 58.2 112.8 215.1 75.1 9.9 138.2 15.5 14.1 84.2 13.1 39.0 13.8 14.7 76.9 37.6 19.9 10.9 181.4 15.7 69.8 25.1 17.5 52.3 48.4 54.1 51.5 52.9 47.8 50.3 52.1 50.2 52.7 51.1 52.6 59.4 29.4 9.6 56.3 11.1 67.7 74.9 81.8 70.6 66.6 16.2 62.7 39.4 32.1 61.5 51.5 71.7 37.5 202.9 33.6 42.7 137.0 97.1 6.0 32.9 36.9 56.9 64.8 54.3 13.1 74.1 92.2 67.5 46.9 34.3 28.5 37.5 38.2 121.6 153.9 20.2 13.7 58.2 61.1 158.7 145.4 13.2 86.6 128.5 80.0 16.9 123.2 24.8 64.9 5.5 19.6 62.3 93.5 89.9 66.2 145.2 121.1 202.3 57.9 18.9 39.5 93.4 39.5 35.4 51.3 75.4 82.8 186.5 46.5 35.5 69.5 123.5 SPG7 "CAR, CMAR, SPG5C" ENSG00000197912 "SPG7 matrix AAA peptidase subunit, paraplegin" Q9UQ90 16 89490719-89557766 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration, Osteogenesis imperfecta" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 11: Basophils - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 52: Non-specific - Transcription" "unprognostic (1.42e-1)" "unprognostic (1.72e-1)" "unprognostic (4.12e-2)" "prognostic favorable (2.22e-4)" "unprognostic (4.10e-1)" "unprognostic (1.11e-2)" "unprognostic (1.14e-1)" "unprognostic (1.50e-1)" "unprognostic (1.54e-1)" "unprognostic (2.33e-1)" "prognostic favorable (4.91e-4)" "unprognostic (3.56e-2)" "unprognostic (7.01e-2)" "unprognostic (1.44e-2)" "unprognostic (2.58e-1)" "unprognostic (1.71e-1)" "prognostic favorable (4.25e-4)" 29.8 44.8 19.3 7.0 18.8 8.2 27.9 21.3 28.6 31.5 18.5 33.3 9.9 31.8 4.0 28.2 26.4 6.8 52.3 19.4 18.3 32.4 47.0 24.9 8.9 19.7 18.6 39.0 31.9 13.8 38.7 5.9 20.3 31.2 8.1 9.9 29.0 9.7 56.7 31.3 35.5 9.0 16.9 34.1 31.1 31.9 18.7 10.5 53.1 31.0 8.0 30.1 26.9 20.0 11.5 28.3 17.3 26.6 33.2 24.2 10.9 27.3 24.6 21.0 10.4 23.0 22.3 16.5 32.5 20.1 16.2 30.5 21.5 24.4 14.7 11.7 25.3 11.4 12.0 43.4 16.2 5.5 10.3 15.2 20.1 12.8 14.1 27.9 25.6 22.0 23.1 5.5 21.7 21.0 14.4 22.5 21.9 23.8 21.4 31.8 26.2 10.8 15.9 17.3 16.4 10.5 44.9 8.3 9.5 15.2 22.6 17.0 33.7 13.9 17.2 12.0 12.2 13.7 19.8 12.8 17.7 19.8 17.7 4.5 2.5 3.9 2.7 2.4 2.6 1.6 1.7 1.3 2.8 3.4 3.1 2.0 2.9 3.7 1.7 2.3 1.8 1.0 19.3 18.8 21.3 28.6 19.4 18.3 19.7 18.6 20.3 16.9 18.7 20.0 53.9 48.1 49.4 39.2 45.6 15.9 27.9 30.1 44.9 57.8 31.2 37.2 45.8 22.8 41.5 35.0 95.9 39.9 47.6 42.3 19.6 40.0 66.0 50.5 41.7 49.9 37.2 27.3 58.5 25.8 28.8 35.9 67.2 54.1 21.5 95.3 51.0 38.1 32.2 40.4 53.1 43.8 30.5 34.8 21.8 22.1 42.9 35.2 21.4 35.6 42.6 30.5 51.5 87.0 46.2 39.5 39.5 33.4 43.5 29.5 68.2 23.8 37.7 73.7 6.6 36.9 36.2 57.5 36.5 36.7 18.0 25.9 45.5 68.3 51.0 28.7 SPNS2 SLC62A2 ENSG00000183018 "Sphingolipid transporter 2" Q8IVW8 17 4498881-4539035 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Lipid transport, Transport" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 51.0" "Cell type enhanced" "Detected in many" "Adipocytes: 32.7;Endothelial cells: 34.5;Microglial cells: 37.5;Oligodendrocytes: 97.8;Urothelial cells: 39.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 31.0;RPTEC TERT1: 161.7;SK-BR-3: 76.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA068717 Uncertain NA NA "Cluster 27: Brain & Skin - Unknown function" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "HPA068717: AB_2686021" "unprognostic (3.03e-2)" "unprognostic (4.76e-2)" "unprognostic (8.08e-2)" "unprognostic (3.53e-2)" "unprognostic (2.78e-1)" "unprognostic (6.30e-3)" "unprognostic (1.10e-3)" "unprognostic (2.33e-1)" "unprognostic (1.70e-1)" "unprognostic (1.63e-3)" "unprognostic (2.99e-2)" "unprognostic (2.98e-2)" "unprognostic (4.48e-2)" "unprognostic (2.20e-2)" "unprognostic (1.68e-1)" "unprognostic (2.19e-2)" "unprognostic (6.89e-2)" 17.3 2.6 13.1 5.2 14.0 7.9 14.7 13.1 18.2 14.6 0.1 6.5 12.2 8.6 0.6 51.0 7.8 12.1 10.7 14.1 12.1 28.6 3.8 28.3 4.9 26.4 16.2 1.8 10.0 1.1 2.1 7.9 28.9 5.3 2.1 0.6 16.5 2.0 4.4 24.8 10.8 4.8 13.9 11.4 21.0 1.3 15.5 1.7 8.5 3.9 13.3 6.6 22.6 25.1 9.7 1.2 0.0 0.2 0.0 0.0 31.0 0.0 0.0 0.0 0.0 0.5 8.1 0.5 11.8 0.0 0.1 0.5 0.0 0.7 0.0 0.1 0.2 0.6 0.2 0.0 0.1 3.0 0.0 0.0 0.2 0.0 0.0 0.0 4.2 4.7 0.0 0.0 0.0 3.8 0.2 17.0 0.1 17.6 0.3 0.8 0.0 0.3 161.7 0.5 5.4 0.2 0.0 76.7 0.0 5.1 2.7 7.5 0.2 0.2 0.7 0.3 0.1 0.3 0.3 0.1 0.0 8.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 13.1 14.0 13.1 18.2 14.1 12.1 26.4 16.2 28.9 13.9 15.5 25.1 32.7 6.4 10.6 1.6 0.2 1.8 0.4 2.1 0.0 1.2 4.3 3.6 1.2 22.8 16.2 22.0 0.0 1.3 0.2 2.8 1.9 16.7 0.2 0.5 1.0 34.5 0.0 3.2 23.4 3.0 30.5 1.7 26.0 2.8 0.0 0.0 12.5 6.7 1.1 6.7 26.2 12.7 2.0 0.3 1.6 0.2 0.6 1.9 1.8 37.5 0.0 0.4 0.0 3.5 97.8 18.6 0.0 0.4 1.2 11.7 1.9 24.3 16.9 1.1 0.0 1.4 3.1 0.6 0.5 0.6 2.4 1.9 1.6 0.1 1.1 39.8 SPR SDR38C1 ENSG00000116096 "Sepiapterin reductase" P35270 2 72887382-72892158 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Disease variant, Dystonia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 85.3;Exocrine glandular cells: 81.1;Proximal tubular cells: 91.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 7 "classical monocyte: 8.3;intermediate monocyte: 2.4;myeloid DC: 8.9" "Group enriched" "Detected in many" 11 "dendritic cells: 8.9;monocytes: 8.3" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039505 Uncertain Supported Nucleoplasm,Cytosol NA NA 180000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 22: Non-specific - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 1: Pancreatic cells - Digestion" "Nucleoplasm, Cytosol" "HPA039505: AB_10795466" "unprognostic (4.09e-1)" "unprognostic (1.22e-1)" "unprognostic (7.72e-3)" "unprognostic (1.97e-1)" "unprognostic (2.46e-2)" "unprognostic (1.06e-2)" "unprognostic (1.36e-1)" "unprognostic (1.47e-1)" "unprognostic (1.12e-1)" "unprognostic (9.79e-2)" "unprognostic (1.62e-1)" "unprognostic (1.37e-1)" "unprognostic (1.80e-1)" "unprognostic (7.50e-3)" "unprognostic (2.87e-1)" "unprognostic (1.43e-3)" "unprognostic (1.95e-1)" 25.9 50.8 26.0 7.6 27.2 0.6 20.0 27.2 61.4 14.5 39.6 36.4 23.4 13.4 36.9 19.7 26.3 11.9 44.4 26.8 30.0 44.2 99.8 15.9 3.2 27.9 31.5 12.2 63.5 38.4 10.9 6.8 29.8 26.2 32.5 3.1 31.2 16.7 43.9 9.1 22.0 11.5 27.9 9.6 42.1 7.3 28.5 2.4 20.5 25.4 5.1 25.2 13.7 28.0 47.5 130.9 0.6 20.0 51.2 18.5 31.8 21.4 31.8 16.0 15.0 84.0 48.0 34.5 25.4 26.1 80.6 43.9 58.1 35.1 13.3 10.0 43.7 51.7 30.8 87.4 19.1 8.2 13.6 16.7 38.7 17.6 19.7 32.7 42.6 25.4 54.0 6.8 21.4 100.5 3.3 31.1 10.9 139.9 118.7 0.0 82.8 20.3 85.8 73.4 8.0 14.6 39.6 89.7 31.0 16.9 40.4 9.9 52.8 17.4 42.2 30.5 38.7 7.2 16.9 2.3 25.0 17.6 31.0 0.0 8.3 0.7 0.3 2.4 0.3 0.0 0.1 0.1 8.9 0.0 0.1 0.3 0.0 0.0 0.9 0.9 0.0 2.4 26.0 27.2 27.2 61.4 26.8 30.0 27.9 31.5 29.8 27.9 28.5 28.0 13.8 12.8 7.3 0.3 1.1 8.4 23.0 14.8 20.5 0.7 22.2 16.5 46.2 38.6 10.8 42.3 0.0 18.1 0.4 85.3 21.5 56.9 0.3 12.5 4.2 16.7 11.4 6.6 0.7 81.1 10.6 13.9 26.0 6.7 4.5 8.4 17.2 62.9 42.1 1.7 0.4 39.6 12.2 6.0 7.4 1.5 9.3 9.7 14.2 1.9 20.8 13.8 0.0 0.0 0.3 43.3 50.4 5.7 1.4 33.9 71.0 91.6 11.2 0.7 6.6 8.3 8.6 0.4 10.2 17.8 6.5 4.4 1.9 8.7 57.8 15.6 SPTAN1 ENSG00000197694 "Spectrin alpha, non-erythrocytic 1" Q13813 9 128552558-128633662 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Actin capping, Actin-binding, Calmodulin-binding" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Bipolar cells: 296.6;Cone photoreceptor cells: 310.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004581, HPA007927" Enhanced Approved Vesicles,Microtubules NA NA 1600000 "Cluster 13: T-cells - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 20: HeLa - Mitochondria" "Cluster 9: Photoreceptor cells - Phototransduction" "Vesicles, Microtubules" "CAB004581: AB_671135, HPA007927: AB_1857435" "unprognostic (1.46e-2)" "unprognostic (2.73e-2)" "unprognostic (1.56e-1)" "unprognostic (9.06e-2)" "unprognostic (3.24e-1)" "unprognostic (4.02e-2)" "unprognostic (2.56e-3)" "unprognostic (2.20e-1)" "unprognostic (1.81e-1)" "unprognostic (1.30e-2)" "unprognostic (2.49e-1)" "unprognostic (1.36e-1)" "prognostic favorable (1.84e-12)" "unprognostic (2.94e-2)" "unprognostic (1.60e-1)" "unprognostic (4.18e-3)" "unprognostic (2.19e-3)" 48.8 31.4 81.7 38.6 85.0 28.1 36.6 54.4 99.7 39.4 0.4 47.3 24.7 57.1 32.9 36.8 54.0 32.5 65.7 90.9 43.5 34.6 22.8 55.1 38.5 142.7 49.6 51.6 24.0 47.1 32.5 57.1 155.0 32.7 36.3 103.1 31.9 46.5 23.9 69.4 34.9 58.8 65.6 44.3 31.1 44.9 61.5 45.4 38.4 22.3 38.0 40.0 36.4 55.3 108.1 116.9 75.2 83.4 107.6 121.0 61.5 90.2 75.2 99.4 74.1 167.3 74.6 94.3 78.3 137.0 69.8 193.3 80.7 90.4 61.1 53.2 47.9 15.9 324.4 94.4 61.3 70.9 51.0 58.3 71.6 166.3 55.8 83.9 134.4 87.2 9.1 107.6 98.6 74.6 136.3 29.5 96.1 125.9 72.1 91.0 90.2 59.7 80.2 91.1 58.1 91.1 296.1 40.3 42.9 91.8 70.0 19.8 232.5 68.5 102.2 100.0 71.2 65.3 82.6 51.8 83.5 31.5 65.9 3.3 1.6 3.9 9.7 1.3 13.5 6.3 12.4 9.2 2.4 5.8 7.6 7.9 1.5 7.1 1.2 3.0 15.3 5.8 81.7 85.0 54.4 99.7 90.9 43.5 142.7 49.6 155.0 65.6 61.5 55.3 144.9 70.5 27.5 123.7 56.3 37.3 27.8 34.3 25.6 296.6 69.8 83.2 68.5 68.6 33.9 101.2 310.6 27.5 112.6 145.4 7.9 67.6 18.0 108.2 71.4 103.8 56.9 13.7 159.5 59.2 16.0 77.8 76.5 87.5 12.0 47.9 96.8 36.2 29.2 124.5 183.8 54.1 30.5 22.2 29.4 40.5 85.1 32.8 35.6 74.9 24.4 97.7 48.4 87.4 17.4 102.2 93.0 94.8 70.5 45.9 62.4 22.8 71.3 156.5 26.3 53.0 60.0 33.0 44.5 43.7 45.5 18.2 95.4 22.0 73.6 65.7 SPTBN2 SCA5 ENSG00000173898 "Spectrin beta, non-erythrocytic 2" O15020 11 66682497-66729226 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Actin capping, Actin-binding" "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 73.6;skin 1: 85.5" "Cell type enhanced" "Detected in many" "Collecting duct cells: 86.5;Cone photoreceptor cells: 104.3;Early spermatids: 30.9;Late spermatids: 77.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HeLa: 45.6;NTERA-2: 49.1;SCLC-21H: 49.9;SK-BR-3: 52.3;T-47d: 67.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009844, HPA039293, HPA043529" Enhanced Supported "Vesicles,Plasma membrane,Cytosol" NA NA "Cluster 27: Brain & Skin - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 9: Photoreceptor cells - Phototransduction" "Plasma membrane, Cytosol" Vesicles "CAB009844: AB_2194521, HPA039293: AB_2676430, HPA043529: AB_2678531" "unprognostic (9.34e-2)" "unprognostic (5.71e-2)" "unprognostic (4.89e-2)" "unprognostic (3.41e-3)" "unprognostic (4.91e-1)" "unprognostic (6.05e-3)" "unprognostic (4.45e-2)" "unprognostic (1.38e-2)" "unprognostic (7.25e-2)" "unprognostic (1.67e-2)" "prognostic unfavorable (3.14e-5)" "unprognostic (1.64e-1)" "unprognostic (1.05e-3)" "unprognostic (1.34e-1)" "unprognostic (1.84e-1)" "unprognostic (3.99e-2)" "unprognostic (1.00e-3)" 1.3 14.4 26.8 1.0 32.6 2.3 7.7 29.7 73.6 14.3 0.0 0.9 0.9 1.7 1.2 39.8 3.7 1.7 1.4 38.8 0.3 37.5 23.3 1.1 0.2 4.8 0.9 0.9 16.7 13.1 16.4 0.4 3.2 12.4 0.7 14.7 29.6 4.7 0.5 85.5 1.0 1.1 0.0 0.9 2.9 52.8 4.6 1.0 0.3 0.1 6.7 1.6 16.5 24.2 20.5 7.4 3.4 0.3 0.1 0.0 0.6 0.3 0.1 0.1 0.0 4.8 28.2 0.2 3.7 0.0 0.7 16.9 25.2 2.4 0.0 0.1 10.4 0.1 45.6 3.0 0.8 7.3 0.6 0.2 11.5 0.0 7.4 4.2 6.3 5.2 7.3 0.1 0.1 35.2 6.3 3.5 49.1 28.7 21.1 23.8 2.8 14.7 9.6 4.8 49.9 29.4 14.0 52.3 3.2 2.7 67.2 2.4 1.4 0.1 8.6 1.3 11.5 0.7 3.0 14.7 0.1 0.1 1.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 26.8 32.6 29.7 73.6 38.8 0.3 4.8 0.9 3.2 0.0 4.6 24.2 0.7 3.2 1.1 4.9 0.3 3.7 2.7 3.2 2.8 11.0 4.7 4.6 1.8 1.5 4.6 86.5 104.3 0.9 0.0 0.6 0.0 2.6 30.9 3.6 1.8 1.1 3.0 7.2 29.3 10.0 0.3 0.8 1.5 3.6 0.0 1.4 1.4 24.7 0.1 0.0 20.7 1.6 0.0 0.3 0.7 77.6 1.8 0.1 0.0 2.8 0.6 1.6 0.0 7.5 4.6 7.5 0.2 1.5 0.8 3.2 0.2 1.3 3.5 21.3 0.0 0.2 0.5 8.5 9.4 14.6 12.5 0.3 0.2 0.1 0.8 1.7 SPTLC1 "hLCB1, HSAN1, HSN1, LCB1, SPTI" ENSG00000090054 "Serine palmitoyltransferase long chain base subunit 1" O15269 9 92000087-92115413 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Lipid metabolism, Sphingolipid metabolism" "Acyltransferase, Transferase" "Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 94.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA010860, CAB018747, HPA063907" Supported Supported "Endoplasmic reticulum" NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 1: Thyroid gland - Transcription" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 7: Non-specific - Mitochondria" "Endoplasmic reticulum" "CAB018747: AB_2195864, HPA010860: AB_1080086, HPA063907: AB_2685148" "unprognostic (1.22e-1)" "unprognostic (1.75e-2)" "unprognostic (1.47e-1)" "unprognostic (3.51e-2)" "unprognostic (1.54e-1)" "unprognostic (1.23e-2)" "unprognostic (3.03e-2)" "unprognostic (4.22e-3)" "unprognostic (1.27e-1)" "unprognostic (4.06e-1)" "unprognostic (3.55e-3)" "unprognostic (8.37e-2)" "prognostic favorable (1.36e-6)" "unprognostic (1.13e-1)" "unprognostic (2.41e-2)" "unprognostic (4.28e-1)" "unprognostic (1.49e-1)" 35.6 32.6 24.0 27.3 27.0 23.3 44.1 26.0 34.2 43.1 28.6 42.3 34.7 40.4 41.3 54.3 36.7 34.1 21.5 24.3 26.6 42.8 23.4 33.6 25.7 27.8 27.5 43.8 26.5 48.0 17.3 42.4 28.0 32.9 44.1 19.8 31.3 28.1 14.2 41.3 37.9 31.4 27.9 26.3 37.1 26.5 25.6 25.9 53.0 18.6 34.4 37.2 34.7 31.6 73.0 48.8 46.8 41.6 120.0 92.0 78.4 74.7 94.2 65.3 66.3 31.5 150.7 38.6 45.1 93.9 78.3 198.4 49.7 68.1 73.0 39.8 36.1 36.7 32.7 51.7 80.5 65.5 49.9 82.6 92.6 68.0 74.8 72.3 62.5 43.5 83.8 46.6 91.1 69.6 34.7 47.6 67.5 97.4 57.9 39.4 58.7 33.3 84.1 37.9 35.0 37.2 104.4 81.1 61.3 62.4 39.2 54.2 72.3 58.8 48.0 73.9 56.8 33.2 44.4 23.9 74.2 39.3 79.4 32.4 33.1 20.2 16.7 36.1 17.0 15.4 18.0 17.4 30.6 15.5 21.4 16.6 33.3 18.5 34.2 18.4 25.7 25.5 24.0 27.0 26.0 34.2 24.3 26.6 27.8 27.5 28.0 27.9 25.6 31.6 40.7 38.5 38.3 27.7 22.1 10.6 13.6 14.5 26.2 6.9 33.2 20.6 4.1 4.3 25.9 36.8 14.6 12.7 24.4 8.0 9.8 53.4 94.8 34.7 42.5 23.1 2.4 7.2 35.3 56.4 15.6 32.3 13.7 47.4 24.6 26.9 6.1 4.3 11.0 6.7 32.5 7.2 12.2 5.7 10.3 26.1 6.2 24.6 12.4 20.6 22.0 13.7 7.2 36.7 52.1 60.8 7.1 6.0 26.2 9.8 11.7 28.5 28.0 8.7 13.1 12.1 23.5 35.3 25.9 27.6 9.1 21.8 21.9 33.2 6.9 14.5 SPTLC2 "hLCB2a, KIAA0526, LCB2, LCB2A" ENSG00000100596 "Serine palmitoyltransferase long chain base subunit 2" O15270 14 77505997-77616637 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Lipid metabolism, Sphingolipid metabolism" "Acyltransferase, Transferase" "Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 164.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA No "Cluster 14: Monocytes - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 36: HEL - Hemostasis" "Cluster 10: Non-specific - Unknown function" "unprognostic (3.16e-1)" "unprognostic (2.82e-2)" "unprognostic (1.24e-1)" "unprognostic (4.41e-2)" "unprognostic (2.12e-1)" "unprognostic (1.42e-1)" "prognostic unfavorable (3.62e-4)" "unprognostic (1.46e-2)" "unprognostic (3.09e-1)" "unprognostic (4.05e-1)" "unprognostic (1.98e-2)" "unprognostic (2.51e-1)" "prognostic favorable (6.69e-8)" "unprognostic (1.29e-2)" "unprognostic (2.35e-1)" "unprognostic (4.94e-2)" "unprognostic (1.32e-1)" 17.6 12.2 14.6 12.6 26.7 33.7 18.3 24.0 19.4 15.2 9.9 18.5 14.5 10.5 7.6 22.8 14.2 11.8 6.7 15.3 18.1 17.6 7.7 13.1 12.0 30.7 21.5 10.4 5.7 10.7 6.2 20.4 31.5 8.4 19.8 14.2 13.7 8.8 3.9 12.2 17.4 11.6 25.3 19.6 20.4 5.0 21.7 10.3 10.9 6.1 13.3 15.0 10.8 52.7 28.9 18.5 14.1 15.5 14.3 17.8 23.7 41.7 30.8 28.2 29.3 23.7 62.3 28.8 10.4 42.7 14.5 34.7 38.1 23.7 42.5 12.6 11.0 82.5 13.4 14.3 12.1 8.4 25.8 11.7 11.4 18.4 20.4 16.3 40.6 19.4 16.2 13.5 16.2 24.9 22.2 28.7 9.2 45.4 16.8 23.5 14.3 10.0 32.9 63.4 13.6 17.1 15.0 50.3 15.8 24.7 61.8 15.3 25.9 25.7 18.2 9.6 9.7 7.6 13.4 19.1 17.3 29.4 14.8 18.3 31.3 27.1 6.1 24.2 5.7 6.7 5.1 6.8 31.2 7.9 3.5 5.8 19.1 17.7 31.8 11.1 6.0 13.4 14.6 26.7 24.0 19.4 15.3 18.1 30.7 21.5 31.5 25.3 21.7 52.7 125.1 28.9 27.3 24.8 27.3 32.4 28.3 27.0 15.4 15.7 24.3 18.4 8.9 15.7 30.7 47.8 35.5 11.9 28.3 37.6 1.9 24.0 1.6 44.1 36.0 53.1 13.2 51.3 31.2 16.1 12.3 18.9 43.3 36.0 51.3 37.2 68.2 7.2 25.1 5.0 29.5 39.3 20.3 75.9 19.8 1.7 14.6 66.2 19.6 83.4 51.3 8.8 32.0 59.3 164.0 35.0 30.4 15.8 11.0 27.0 28.4 8.8 33.5 20.0 32.9 10.5 25.5 7.3 19.0 37.7 29.1 6.6 23.3 14.6 33.0 60.0 SQSTM1 "A170, OSIL, p60, p62, p62B, PDB3" ENSG00000161011 "Sequestosome 1" Q13501 5 179806398-179838078 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Apoptosis, Autophagy, Differentiation, Immunity" "Amyotrophic lateral sclerosis, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 1183.4" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 2045.0;Urothelial cells: 2233.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 1923.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004587, HPA064165, HPA068843" Supported Enhanced Vesicles,Cytosol No No 81000 "Cluster 38: Basophils - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 44: HDLM-2 - Immune response" "Cluster 22: Epithelial cell types - Mixed function" "Vesicles, Cytosol" "CAB004587: AB_628279, HPA064165: AB_2685203, HPA068843: AB_2732120" "unprognostic (1.08e-1)" "unprognostic (1.39e-1)" "unprognostic (3.19e-1)" "unprognostic (9.45e-2)" "unprognostic (1.47e-2)" "unprognostic (1.08e-1)" "prognostic unfavorable (2.31e-5)" "unprognostic (1.34e-1)" "unprognostic (2.34e-1)" "unprognostic (5.65e-2)" "unprognostic (1.66e-1)" "unprognostic (1.70e-1)" "unprognostic (9.52e-2)" "unprognostic (3.21e-1)" "unprognostic (8.68e-3)" "unprognostic (4.41e-2)" "unprognostic (2.01e-1)" 335.0 472.6 171.4 86.0 208.8 135.8 269.5 199.6 207.2 242.8 218.9 262.0 112.1 278.8 91.7 192.3 207.5 188.2 310.1 163.8 200.6 221.5 392.0 263.4 81.4 203.9 183.3 235.6 231.3 121.4 181.5 118.7 190.5 206.2 82.3 46.4 289.7 174.2 1183.4 194.7 187.4 132.7 179.5 179.0 263.6 65.7 205.7 89.4 316.4 287.2 96.4 347.3 211.0 236.5 130.1 740.6 36.9 114.3 547.8 384.8 546.3 187.9 596.3 164.1 201.2 154.6 532.9 16.0 522.7 298.9 898.3 170.8 79.9 181.9 76.9 1923.9 97.6 58.5 303.9 223.4 1167.2 59.9 365.0 337.1 181.2 273.0 441.5 390.8 152.6 17.3 68.0 472.1 327.0 111.6 26.4 62.0 93.8 410.0 195.1 54.8 78.8 213.7 243.6 609.6 79.0 74.5 253.2 274.3 662.2 62.3 143.8 120.4 286.2 243.1 103.4 252.3 271.6 723.7 819.3 73.5 521.1 111.6 338.4 807.6 412.3 422.2 194.7 268.3 231.3 156.5 170.1 174.6 227.5 168.2 131.8 139.1 672.6 196.3 260.3 89.6 262.1 439.8 171.4 208.8 199.6 207.2 163.8 200.6 203.9 183.3 190.5 179.5 205.7 236.5 411.1 185.9 248.8 36.9 280.0 297.5 1289.0 320.4 799.6 81.7 280.7 253.0 38.5 314.5 247.8 121.4 54.2 266.8 276.4 572.9 234.8 906.0 34.2 408.7 255.4 415.8 340.4 89.0 35.2 686.7 133.2 516.0 1270.6 589.7 386.3 73.8 142.5 297.8 288.3 90.9 37.2 337.2 236.0 149.8 556.3 72.2 325.3 388.3 231.3 28.1 611.3 143.3 125.7 16.6 62.2 639.4 618.9 259.2 606.5 1281.6 311.3 327.1 190.1 73.5 164.3 356.4 316.1 45.5 48.0 595.4 259.1 2045.0 259.9 133.4 242.3 2233.9 SRPX2 SRPUL ENSG00000102359 "Sushi repeat containing protein X-linked 2" O60687 X 100644195-100675788 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" "Angiogenesis, Cell adhesion" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 31.8" "Cell type enhanced" "Detected in many" "Adipocytes: 20.9;Fibroblasts: 34.3;Granulosa cells: 21.6;Microglial cells: 37.5;Skeletal myocytes: 17.5;Urothelial cells: 49.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 282.3;ASC TERT1: 116.9;HSkMC: 103.3;HUVEC TERT2: 72.7" "Low region specificity" "Detected in many" "Region enhanced" "Detected in single" "spinal cord: 2.8" HPA038786 Approved "Secreted to blood" NA NA "Cluster 82: Adipose tissue - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "HPA038786: AB_10672724" "unprognostic (4.10e-2)" "unprognostic (4.55e-2)" "unprognostic (2.08e-1)" "unprognostic (3.72e-2)" "unprognostic (1.96e-1)" "unprognostic (4.21e-3)" "unprognostic (3.59e-3)" "unprognostic (5.41e-2)" "unprognostic (3.22e-2)" "unprognostic (1.26e-1)" "unprognostic (2.86e-2)" "unprognostic (2.29e-1)" "prognostic unfavorable (0.00e+0)" "unprognostic (1.84e-3)" "unprognostic (1.69e-1)" "unprognostic (8.67e-2)" "unprognostic (3.85e-1)" 31.8 7.5 3.6 6.3 4.5 0.2 20.7 1.3 2.6 11.3 8.5 7.1 1.2 6.0 0.9 17.7 7.1 3.1 12.7 2.8 5.8 13.9 5.4 13.8 0.4 4.3 5.6 8.3 2.9 0.7 2.5 9.3 3.1 6.3 1.8 0.1 4.6 3.8 3.4 3.7 5.1 4.4 2.0 12.9 4.5 1.1 7.4 0.3 4.3 4.8 1.2 16.8 10.9 2.5 11.7 1.2 2.9 0.1 282.3 116.9 0.0 26.3 19.8 8.0 25.1 1.4 17.6 0.0 1.1 15.9 7.5 0.7 0.2 13.1 8.6 0.1 0.1 0.2 0.9 2.8 29.3 0.2 0.6 103.3 0.3 27.8 0.9 24.6 72.7 0.0 0.0 0.1 27.1 0.0 0.0 0.0 3.4 0.2 0.3 0.0 2.5 0.0 11.4 37.6 0.4 0.0 0.0 0.8 0.2 6.1 0.3 0.1 36.7 13.8 12.3 10.3 0.9 0.1 0.0 0.1 18.3 0.0 8.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 4.5 1.3 2.6 2.8 5.8 4.3 5.6 3.1 2.0 7.4 2.5 20.9 0.0 0.6 10.1 0.3 0.4 5.0 6.5 0.6 0.0 4.8 1.8 0.9 0.0 13.7 0.0 0.0 0.2 0.0 1.9 0.0 1.6 3.6 0.6 11.2 1.6 0.0 0.0 0.4 0.0 0.4 34.3 1.1 0.4 0.0 21.6 4.6 0.2 0.9 0.0 0.2 0.1 4.1 0.3 1.6 2.7 15.8 0.3 0.0 37.5 0.0 0.0 0.0 2.0 0.1 0.8 0.0 6.0 0.2 1.6 0.0 0.1 15.5 0.0 0.0 17.5 14.6 0.2 0.1 0.6 0.4 0.5 0.3 2.6 0.4 49.1 SSBP1 "mtSSB, SSBP" ENSG00000106028 "Single stranded DNA binding protein 1" Q04837 7 141738334-141787922 "Human disease related genes, Predicted intracellular proteins" "DNA replication" DNA-binding "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002866 Supported Supported Mitochondria NA NA 150000 "Cluster 44: Non-specific - Transcription" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Mitochondria "HPA002866: AB_1080092" "unprognostic (2.95e-1)" "unprognostic (2.99e-1)" "unprognostic (2.49e-2)" "unprognostic (3.62e-2)" "unprognostic (7.36e-3)" "unprognostic (2.86e-2)" "prognostic unfavorable (4.42e-4)" "unprognostic (3.68e-2)" "unprognostic (6.03e-2)" "prognostic favorable (3.40e-4)" "unprognostic (9.23e-3)" "unprognostic (4.02e-1)" "unprognostic (9.65e-3)" "unprognostic (1.62e-1)" "unprognostic (9.38e-2)" "unprognostic (1.25e-2)" "unprognostic (9.58e-2)" 86.1 105.0 70.5 80.9 72.6 89.9 97.0 72.3 101.1 75.1 65.8 94.1 70.4 83.6 107.7 125.9 74.0 54.0 135.0 71.5 74.5 105.4 120.4 62.9 97.0 72.5 74.4 85.3 87.8 93.6 64.8 78.4 72.8 64.9 85.3 58.2 77.4 70.4 141.2 88.4 77.5 76.1 72.5 80.8 93.1 80.8 70.8 96.6 82.7 94.1 112.8 91.8 82.1 74.4 280.6 333.6 281.6 369.2 125.5 193.2 262.2 208.7 193.0 256.4 287.9 353.7 330.5 414.0 267.6 173.5 421.8 210.2 349.5 347.4 369.6 220.8 339.1 226.1 253.6 322.3 242.6 644.9 166.8 179.9 230.9 257.4 373.0 177.7 316.2 279.9 552.8 184.0 343.4 430.9 477.3 837.2 634.1 476.8 403.0 262.6 258.2 578.5 340.9 286.7 256.4 352.5 236.8 323.7 319.8 213.7 210.7 267.2 239.6 183.0 171.6 282.1 533.8 328.6 465.9 796.1 369.9 577.6 395.8 136.1 69.9 76.8 71.7 96.1 107.7 106.3 113.8 98.9 90.6 92.0 101.1 113.7 20.6 98.8 99.8 104.0 123.8 116.3 70.5 72.6 72.3 101.1 71.5 74.5 72.5 74.4 72.8 72.5 70.8 74.4 151.0 102.5 104.7 13.7 135.7 116.0 199.6 477.7 98.4 58.6 114.3 178.8 279.1 148.7 242.7 150.8 41.7 311.0 139.2 92.7 350.2 310.3 187.0 160.6 162.3 136.5 96.3 111.7 17.0 353.3 313.7 140.5 92.2 169.8 151.9 163.3 105.3 221.9 251.9 43.7 16.0 163.7 244.1 122.0 126.3 62.2 137.3 131.0 104.9 15.0 221.2 152.1 157.6 16.6 29.1 314.0 130.0 123.8 101.3 166.6 141.9 445.2 178.0 79.1 98.6 170.6 223.5 253.5 190.0 136.3 129.4 261.7 145.2 254.1 188.1 200.2 ST3GAL3 "MRT12, SIAT6" ENSG00000126091 "ST3 beta-galactoside alpha-2,3-sialyltransferase 3" Q11203 1 43705824-43931165 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 88.0;tongue: 82.9" "Cell type enhanced" "Detected in many" "Astrocytes: 59.7;Excitatory neurons: 94.4;Granulosa cells: 52.5;Inhibitory neurons: 120.1;Microglial cells: 57.1;Oligodendrocyte precursor cells: 66.9;Oligodendrocytes: 66.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA051102 Uncertain "Intracellular and membrane" NA NA "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 43: THP-1 - Innate immune response" "Cluster 40: Granulosa cells - Unknown function" "HPA051102: AB_2681344" "unprognostic (8.42e-2)" "unprognostic (1.38e-1)" "unprognostic (1.41e-2)" "unprognostic (5.18e-2)" "unprognostic (1.22e-1)" "unprognostic (3.20e-1)" "unprognostic (9.72e-2)" "unprognostic (7.01e-2)" "unprognostic (4.39e-2)" "unprognostic (2.33e-2)" "unprognostic (1.38e-3)" "unprognostic (7.00e-2)" "unprognostic (3.68e-3)" "unprognostic (1.67e-2)" "unprognostic (1.30e-1)" "unprognostic (4.35e-1)" "unprognostic (6.60e-2)" 12.9 14.7 28.5 5.0 27.3 11.0 11.0 30.8 32.5 14.6 22.8 19.4 2.6 16.7 9.8 8.3 12.8 6.9 26.1 27.2 29.4 9.9 13.5 8.7 6.1 27.9 29.0 14.9 8.0 6.7 17.8 6.5 29.2 13.2 4.4 24.5 8.3 13.3 88.0 7.0 6.6 13.1 23.2 7.6 9.6 22.6 30.8 4.9 8.4 82.9 3.7 16.7 10.1 28.1 4.3 2.7 23.4 11.0 17.4 21.9 3.0 15.5 30.8 14.1 13.7 2.6 6.6 7.0 8.6 19.0 7.7 3.8 2.8 10.2 15.7 8.7 5.8 15.0 10.6 7.5 14.7 6.6 7.1 12.1 7.4 9.7 21.3 26.1 12.1 18.4 8.8 13.1 25.3 2.7 7.0 11.7 9.2 1.0 8.1 11.4 3.3 6.1 11.0 2.4 9.3 13.8 5.5 2.5 14.1 9.6 3.5 30.3 10.4 8.3 3.9 13.3 15.4 10.4 6.1 6.9 11.7 15.7 15.3 1.7 2.1 1.2 3.3 1.1 2.9 2.2 2.1 2.5 1.5 2.8 3.5 2.6 2.4 2.2 1.9 3.3 2.9 3.3 28.5 27.3 30.8 32.5 27.2 29.4 27.9 29.0 29.2 23.2 30.8 28.1 6.7 6.4 19.3 59.7 6.6 3.3 3.0 4.1 5.7 9.4 4.6 3.3 34.5 1.5 3.8 3.7 0.0 3.1 2.7 2.2 5.9 2.6 19.4 2.4 6.6 7.6 2.4 8.4 94.4 2.4 1.6 9.0 1.5 2.8 24.1 52.5 4.6 8.6 3.1 18.5 120.1 1.4 4.1 2.2 3.1 14.5 3.7 4.5 3.6 57.1 3.6 6.1 5.2 66.9 66.2 2.7 0.2 11.7 4.2 2.2 0.1 6.3 4.9 17.8 19.7 5.8 9.8 8.5 5.1 2.7 1.3 1.0 6.0 15.7 1.7 10.0 ST3GAL5 "SIAT9, SIATGM3S, ST3GalV" ENSG00000115525 "ST3 beta-galactoside alpha-2,3-sialyltransferase 5" Q9UNP4 2 85837120-85905199 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 47.4" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 112.8;Oligodendrocyte precursor cells: 94.0;Oligodendrocytes: 108.4" "Cancer enhanced" "Detected in all" "thyroid cancer: 41.7" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "AN3-CA: 54.4;RT4: 47.0;SK-MEL-30: 40.8;U-266/84: 42.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034708, HPA040425, HPA068928" Uncertain Approved Vesicles NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Vesicles "HPA034708: AB_10601594, HPA040425: AB_2676978, HPA068928: AB_2686060" "unprognostic (7.90e-2)" "unprognostic (1.61e-2)" "unprognostic (3.84e-2)" "unprognostic (2.93e-2)" "unprognostic (1.27e-1)" "unprognostic (1.75e-1)" "unprognostic (1.12e-2)" "unprognostic (5.81e-3)" "unprognostic (1.38e-1)" "unprognostic (6.45e-2)" "unprognostic (5.03e-3)" "unprognostic (3.43e-2)" "prognostic unfavorable (2.25e-7)" "unprognostic (2.22e-1)" "unprognostic (5.74e-2)" "prognostic favorable (4.99e-4)" "prognostic favorable (4.48e-4)" 17.5 47.4 17.1 4.6 26.9 2.3 8.5 16.4 20.1 5.4 7.9 5.0 1.0 9.9 0.9 2.7 10.4 8.1 4.2 16.0 24.7 2.8 9.8 14.6 9.1 24.7 22.6 10.1 3.9 0.4 12.8 17.7 23.1 6.7 2.6 31.0 7.1 0.5 12.4 6.1 6.9 3.5 20.6 20.0 5.6 10.8 23.6 5.0 27.9 3.5 4.4 20.8 5.9 41.6 0.3 27.0 2.5 54.4 22.0 11.8 8.0 5.9 18.0 5.6 5.0 0.5 19.6 0.7 0.2 10.2 2.5 1.0 3.6 6.4 7.0 0.2 3.2 0.6 1.1 1.0 17.6 0.4 7.8 6.9 0.8 2.1 0.8 10.1 13.7 7.4 0.8 30.2 18.3 1.8 1.9 3.1 0.2 9.6 0.0 3.5 17.0 11.0 2.9 47.0 3.8 3.8 0.2 0.1 40.8 5.4 0.2 1.1 4.5 0.1 2.7 0.1 0.4 30.0 42.5 0.5 4.2 5.6 27.7 0.6 0.8 0.1 0.6 3.0 0.8 1.1 0.3 0.4 0.5 0.7 0.3 0.3 0.6 0.6 2.4 0.2 0.1 0.3 17.1 26.9 16.4 20.1 16.0 24.7 24.7 22.6 23.1 20.6 23.6 41.6 8.5 86.6 112.8 37.5 29.1 5.6 27.6 20.5 1.2 56.6 3.1 2.3 1.9 40.0 33.9 3.7 58.4 0.4 48.3 0.2 3.9 12.0 12.3 9.0 27.8 8.1 6.7 0.4 46.9 16.6 1.1 21.7 6.1 8.5 34.8 35.2 29.6 21.1 35.6 72.3 60.2 0.1 12.2 45.4 18.1 12.0 8.1 24.9 32.0 45.9 20.1 56.0 12.3 94.0 108.4 6.2 0.1 1.9 19.5 6.8 0.0 3.7 10.7 45.2 0.0 21.3 5.0 8.4 16.1 0.2 3.8 0.3 28.9 6.3 0.1 8.3 STARD7 GTT1 ENSG00000084090 "StAR related lipid transfer domain containing 7" Q9NQZ5 2 96184859-96208827 "Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Transporters" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033965, HPA064958, HPA064978" Supported Approved Mitochondria "Intracellular and membrane" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 54: Cardiomyocytes - Muscle contraction" Mitochondria "CAB033965: AB_2302780, HPA064958: AB_2685391, HPA064978: AB_2685397" "unprognostic (3.75e-2)" "unprognostic (1.54e-2)" "unprognostic (1.67e-1)" "prognostic unfavorable (8.56e-5)" "prognostic favorable (3.89e-6)" "unprognostic (1.51e-1)" "prognostic unfavorable (2.22e-4)" "unprognostic (2.72e-3)" "unprognostic (2.38e-1)" "unprognostic (2.93e-1)" "unprognostic (4.66e-2)" "unprognostic (1.78e-1)" "prognostic favorable (4.38e-6)" "unprognostic (1.02e-1)" "unprognostic (2.04e-1)" "unprognostic (2.64e-2)" "unprognostic (2.42e-2)" 44.7 54.3 57.8 46.7 62.4 34.3 43.9 61.9 53.2 33.9 60.6 57.6 55.7 29.8 30.5 36.8 44.0 29.1 98.5 49.8 61.4 80.3 62.8 61.1 70.6 56.4 55.5 29.4 42.2 69.7 23.6 29.3 54.9 39.0 56.2 54.4 65.2 45.7 202.5 35.2 45.4 37.6 60.5 53.1 44.6 21.1 66.9 56.2 56.6 174.0 86.9 42.1 27.0 74.4 128.8 79.1 102.3 106.2 134.9 66.9 150.1 122.6 107.0 121.2 129.6 188.8 117.7 228.7 129.0 98.6 95.8 102.3 183.3 106.4 157.3 147.2 131.9 204.1 74.3 218.3 62.2 158.1 106.9 65.4 77.9 101.0 99.1 77.2 123.2 92.6 211.1 89.2 108.8 113.0 175.9 161.0 173.3 110.3 115.2 171.6 156.4 227.1 73.2 162.2 191.6 90.5 62.5 201.8 115.8 126.0 60.5 171.6 103.8 100.1 100.4 112.0 125.8 113.9 114.0 201.7 92.8 174.9 112.6 35.6 25.4 22.7 25.6 30.2 26.1 42.6 21.5 26.6 36.2 37.8 23.6 23.4 3.0 30.8 19.9 42.2 41.5 26.0 57.8 62.4 61.9 53.2 49.8 61.4 56.4 55.5 54.9 60.5 66.9 74.4 32.0 134.6 44.2 21.5 71.2 63.7 43.2 34.3 101.9 39.5 58.1 50.2 176.9 55.8 47.1 46.0 108.4 35.8 83.8 63.3 74.3 32.4 2.5 34.5 43.2 49.9 44.4 48.6 25.6 38.0 40.3 31.3 37.8 48.6 15.8 45.4 41.7 114.7 71.0 40.4 23.8 58.4 24.4 122.4 102.3 6.9 23.3 54.4 42.7 20.6 95.8 38.4 30.9 19.1 42.6 35.8 26.6 25.2 120.6 68.4 50.1 65.7 31.8 58.1 26.3 43.5 43.0 22.7 35.1 75.4 57.4 35.4 62.9 36.8 81.9 38.8 STN1 "bA541N10.2, FLJ22559, OBFC1" ENSG00000107960 "STN1 subunit of CST complex" Q9H668 10 103877569-103918184 "Disease related genes, Human disease related genes, Predicted intracellular proteins" DNA-binding "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 37.4;Distal tubular cells: 41.1;Ductal cells: 34.6;Exocrine glandular cells: 79.2;Pancreatic endocrine cells: 62.9;Theca cells: 52.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037924, HPA037925" Supported Nucleoplasm NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "HPA037924: AB_10671636, HPA037925: AB_10672469" "unprognostic (1.50e-1)" "unprognostic (4.22e-2)" "unprognostic (2.18e-2)" "unprognostic (5.58e-3)" "unprognostic (6.01e-2)" "unprognostic (1.53e-2)" "unprognostic (1.59e-1)" "unprognostic (1.29e-1)" "unprognostic (5.93e-2)" "unprognostic (1.72e-1)" "unprognostic (1.12e-3)" "unprognostic (3.76e-1)" "prognostic favorable (1.12e-6)" "unprognostic (1.21e-1)" "unprognostic (1.74e-1)" "unprognostic (1.20e-1)" "unprognostic (1.83e-2)" 15.7 22.2 8.8 12.2 10.1 13.5 17.1 11.3 9.4 13.3 11.5 14.5 12.0 12.0 9.8 41.0 12.2 18.3 35.0 8.2 11.1 17.9 13.1 25.2 16.0 13.1 11.0 22.2 20.9 33.6 14.9 17.1 11.5 10.2 16.4 6.4 18.7 13.3 22.4 13.3 11.0 15.4 9.9 15.3 22.2 23.4 11.5 24.5 17.6 28.9 22.8 22.5 18.5 11.2 26.8 19.7 23.8 19.6 18.6 57.6 7.6 12.6 36.5 16.4 14.6 11.4 43.6 16.7 22.2 16.1 14.7 24.8 8.7 31.0 15.3 24.1 11.9 15.3 7.0 23.5 25.6 12.7 12.9 37.2 52.1 15.9 43.9 42.9 32.0 31.2 8.5 34.9 27.3 21.7 31.5 22.0 5.5 38.7 28.5 22.7 16.4 19.2 40.5 31.3 13.7 16.1 9.3 14.9 24.4 13.4 12.5 11.0 47.1 20.4 14.1 14.5 19.4 47.3 13.1 16.6 30.4 26.4 9.0 41.7 33.2 110.3 65.1 21.3 103.4 25.5 71.9 60.4 40.2 29.6 52.3 62.6 48.8 71.3 23.7 37.1 100.2 51.5 8.8 10.1 11.3 9.4 8.2 11.1 13.1 11.0 11.5 9.9 11.5 11.2 14.7 22.4 20.9 0.0 2.3 0.0 0.0 0.0 0.0 0.0 12.7 16.9 0.0 0.0 5.0 9.2 0.0 37.4 17.2 0.0 41.1 34.6 0.0 9.2 9.9 6.4 0.0 0.0 0.0 79.2 14.0 3.9 0.0 15.4 5.1 23.8 0.0 0.0 16.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.4 0.0 0.0 13.5 0.0 0.0 0.0 0.0 62.9 0.0 0.0 1.0 0.0 0.0 12.8 7.3 0.0 0.0 0.0 6.7 0.0 0.0 0.0 0.0 27.0 13.3 52.4 0.0 0.0 STRC DFNB16 ENSG00000242866 Stereocilin Q7RTU9 15 43599563-43618800 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Hearing "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Group enriched" "Detected in some" 5 "brain: 9.0;pituitary gland: 4.4;retina: 3.6;testis: 5.0" "Cell type enhanced" "Detected in some" "Astrocytes: 10.1;Excitatory neurons: 55.7;Inhibitory neurons: 35.4;Oligodendrocyte precursor cells: 13.0;Oligodendrocytes: 15.4" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA048083 Enhanced NA NA "Cluster 6: Brain - Smell perception" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA048083: AB_2732545" "unprognostic (8.60e-3)" "unprognostic (5.77e-3)" "unprognostic (6.14e-2)" "unprognostic (1.60e-2)" "unprognostic (1.47e-1)" "unprognostic (1.15e-3)" "unprognostic (1.65e-1)" "unprognostic (1.36e-1)" "unprognostic (1.20e-1)" "unprognostic (1.79e-1)" "unprognostic (1.84e-2)" "unprognostic (5.92e-3)" "unprognostic (1.99e-4)" "unprognostic (1.58e-1)" "unprognostic (6.56e-2)" "unprognostic (1.78e-1)" "unprognostic (1.59e-4)" 0.1 0.6 3.5 0.0 3.8 0.0 0.3 9.0 8.0 0.3 0.3 0.3 0.1 0.1 1.0 0.2 0.4 0.0 0.1 3.8 2.4 0.5 0.6 0.1 0.0 3.8 2.2 0.6 0.2 0.0 4.4 0.0 3.7 1.0 0.0 3.6 0.7 0.0 0.4 0.7 0.4 0.0 1.5 0.3 0.3 5.0 3.2 0.6 1.0 0.0 0.0 0.1 0.3 4.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.5 3.8 9.0 8.0 3.8 2.4 3.8 2.2 3.7 1.5 3.2 4.8 0.2 0.0 0.0 10.1 0.0 0.6 0.1 0.2 0.0 2.6 0.6 0.9 0.3 0.0 0.2 0.0 6.2 0.3 0.0 0.1 0.0 0.1 0.5 0.3 0.1 0.2 0.0 0.0 55.7 0.2 0.1 0.1 0.0 0.3 0.0 2.0 0.4 0.3 0.1 3.3 35.4 0.2 0.0 0.3 0.2 0.5 0.0 0.1 1.8 6.5 0.0 2.3 0.0 13.0 15.4 0.2 1.3 0.4 0.1 0.2 0.7 0.1 0.3 8.7 0.0 0.2 0.1 4.5 0.9 0.0 0.4 0.7 0.2 0.0 0.1 0.0 STUB1 "CHIP, HSPABP2, NY-CO-7, SDCCAG7, UBOX1" ENSG00000103266 "STIP1 homology and U-box containing protein 1" Q9UNE7 16 680224-682870 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB037202, CAB037209, HPA041222, HPA043531" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Cytosol" "CAB037202: AB_1840759, CAB037209: AB_1840757, HPA041222: AB_2677368, HPA043531: AB_2678533" "unprognostic (5.70e-2)" "unprognostic (2.53e-1)" "unprognostic (1.90e-1)" "unprognostic (3.89e-1)" "unprognostic (9.00e-2)" "unprognostic (3.06e-1)" "unprognostic (4.09e-3)" "unprognostic (2.21e-1)" "unprognostic (2.23e-1)" "unprognostic (8.31e-2)" "unprognostic (5.78e-2)" "unprognostic (6.77e-2)" "prognostic favorable (6.49e-9)" "unprognostic (9.67e-2)" "unprognostic (3.57e-1)" "unprognostic (1.55e-1)" "unprognostic (1.30e-1)" 80.2 126.3 185.5 35.6 186.9 48.9 76.0 183.8 242.7 74.8 173.1 100.3 50.7 67.0 60.3 86.8 65.3 42.1 151.1 187.3 185.3 91.4 100.7 65.0 52.5 188.2 184.2 65.7 93.7 90.6 93.7 23.9 187.9 80.2 32.6 33.2 86.6 53.5 201.8 111.7 63.1 40.1 180.6 70.0 86.2 45.1 193.5 42.3 72.9 125.2 38.2 80.7 69.1 188.0 81.6 107.6 59.4 108.0 123.4 102.5 43.8 112.8 95.1 100.9 90.5 131.0 97.1 83.0 78.2 147.5 69.1 69.7 73.0 137.3 42.9 93.6 318.8 53.4 154.1 104.7 183.7 85.9 96.4 141.1 134.3 118.2 71.4 76.3 106.2 72.3 87.1 119.2 149.3 318.4 90.1 85.4 76.4 107.1 127.5 143.5 46.8 200.6 132.5 72.6 121.1 103.4 89.4 165.8 137.1 35.9 114.1 147.8 108.7 104.3 99.8 94.3 125.9 137.6 150.2 132.3 83.8 73.9 122.0 17.7 13.6 21.7 15.7 12.9 14.5 19.6 13.5 13.8 12.1 21.0 12.8 11.6 13.4 11.2 13.9 20.7 13.2 7.2 185.5 186.9 183.8 242.7 187.3 185.3 188.2 184.2 187.9 180.6 193.5 188.0 96.2 38.5 27.9 24.5 88.9 114.7 107.2 63.9 83.1 93.3 137.1 158.7 1.0 104.4 52.4 130.6 52.1 80.1 101.4 142.7 285.7 139.6 8.6 82.8 69.6 71.6 76.0 68.5 23.2 169.7 93.8 85.7 68.3 65.0 21.0 97.9 80.3 122.1 113.1 84.1 21.1 101.4 85.5 69.4 94.9 16.7 109.0 79.0 117.4 15.0 154.4 184.3 110.2 14.1 24.8 190.2 110.8 112.1 108.6 160.8 165.5 324.1 61.2 83.9 72.3 82.3 129.7 50.4 62.4 107.0 120.5 100.7 96.2 132.5 109.3 118.8 STX1B "STX1B1, STX1B2" ENSG00000099365 "Syntaxin 1B" P61266 16 30989256-31010638 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Neurotransmitter transport, Transport" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 13 "brain: 137.2" "Cell type enhanced" "Detected in some" "Excitatory neurons: 36.8;Horizontal cells: 38.7;Inhibitory neurons: 31.1;Late spermatids: 13.8" "Cancer enriched" "Detected in some" 7 "glioma: 5.1" "Region enhanced" "Detected in many" "cerebral cortex: 137.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ hTERT+ SV40 Large T+ RasG12V: 9.0;hTEC/SVTERT24-B: 11.1;hTERT-RPE1: 20.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA069176, CAB079008" Supported Approved Approved "Nuclear membrane,Vesicles" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 62: Horizontal cells - Visual perception" Vesicles "Nuclear membrane" "CAB079008: , HPA069176: AB_2686098" "unprognostic (1.43e-3)" "unprognostic (5.27e-2)" "unprognostic (2.40e-4)" "unprognostic (3.90e-3)" "unprognostic (3.98e-2)" "unprognostic (1.90e-2)" "unprognostic (2.21e-3)" "unprognostic (2.53e-2)" "unprognostic (1.72e-1)" "unprognostic (3.72e-3)" "unprognostic (1.73e-2)" "unprognostic (2.36e-1)" "unprognostic (1.02e-3)" "unprognostic (1.07e-1)" "unprognostic (1.58e-1)" "unprognostic (7.93e-2)" "unprognostic (1.57e-2)" 1.5 1.0 7.0 1.1 13.1 0.4 1.7 20.0 137.2 1.7 0.0 2.5 0.5 3.0 3.3 1.2 1.7 0.3 1.6 15.9 5.2 1.3 5.9 0.5 1.7 51.2 5.5 1.7 0.9 0.2 6.5 0.2 42.9 1.7 0.4 10.2 1.0 1.8 0.5 3.3 1.8 1.6 0.0 1.8 0.9 4.6 5.8 0.5 0.7 0.1 1.5 0.7 1.3 52.8 0.1 3.0 4.7 0.7 0.5 0.2 0.1 4.2 6.4 5.1 9.0 0.0 3.4 0.7 0.2 5.6 0.1 0.7 2.1 0.6 6.1 2.6 0.4 0.4 2.7 2.4 0.4 0.2 2.9 1.6 0.1 11.1 1.0 20.4 0.0 1.0 0.5 0.2 5.5 1.3 2.0 0.2 2.3 0.0 0.3 7.1 0.2 0.2 0.4 0.0 6.3 4.0 0.5 0.2 0.0 0.7 0.8 0.1 0.8 3.0 2.4 0.4 0.2 0.3 0.2 0.3 3.3 0.3 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 7.0 13.1 20.0 137.2 15.9 5.2 51.2 5.5 42.9 0.0 5.8 52.8 0.4 0.0 0.0 7.2 0.6 0.8 0.1 0.2 0.6 10.7 0.4 0.6 1.2 0.0 0.0 0.0 2.1 0.0 0.2 0.1 0.0 0.3 6.9 0.1 0.5 0.8 0.0 0.4 36.8 0.4 0.0 0.7 0.0 0.1 0.0 2.5 1.1 5.9 0.6 38.7 31.1 0.2 0.0 0.6 1.1 13.8 0.3 0.3 0.0 4.7 0.7 1.8 0.0 9.0 5.5 0.2 0.0 1.9 0.0 0.2 0.9 2.1 0.0 3.2 0.0 0.8 0.7 4.6 1.3 0.2 0.6 0.8 0.4 0.1 0.3 0.0 STXBP1 "hUNC18, MUNC18-1, rbSec1, UNC18" ENSG00000136854 "Syntaxin binding protein 1" P61764 9 127579370-127696027 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Protein transport, Transport" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 174.5;pituitary gland: 66.4;retina: 214.2" "Cell type enhanced" "Detected in many" "Bipolar cells: 131.0;Cone photoreceptor cells: 156.4;Excitatory neurons: 243.2;Inhibitory neurons: 157.5;Rod photoreceptor cells: 155.6" "Cancer enhanced" "Detected in all" "melanoma: 39.6" "Region enhanced" "Detected in many" "cerebral cortex: 174.5" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "SCLC-21H: 144.1;SK-MEL-30: 131.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008209, HPA023483, CAB034434" Enhanced Approved Nucleoplasm,Cytosol NA NA 29000 "Cluster 32: T-cells - Unknown function" "Cluster 58: Brain - Synaptic function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoplasm, Cytosol" "CAB034434: AB_2196699, HPA008209: AB_1857624, HPA023483: AB_1857625" "unprognostic (2.32e-2)" "unprognostic (7.33e-2)" "unprognostic (3.85e-2)" "prognostic unfavorable (4.78e-4)" "unprognostic (1.80e-1)" "prognostic unfavorable (1.47e-4)" "prognostic unfavorable (5.73e-4)" "unprognostic (2.87e-2)" "unprognostic (2.31e-1)" "unprognostic (3.08e-3)" "prognostic favorable (9.81e-4)" "unprognostic (1.30e-2)" "unprognostic (1.67e-1)" "unprognostic (2.68e-2)" "unprognostic (5.51e-2)" "unprognostic (7.66e-2)" "unprognostic (3.36e-3)" 27.5 28.8 22.8 7.8 33.2 1.1 21.0 38.6 174.5 21.8 0.0 15.9 5.5 24.1 7.1 10.4 32.3 11.4 24.0 48.3 12.2 14.1 3.1 32.1 6.0 48.7 0.0 25.2 24.8 15.0 66.4 14.1 33.1 10.5 8.4 214.2 15.6 10.4 9.0 11.4 9.3 21.0 0.0 10.4 13.3 9.1 6.8 5.8 20.1 9.2 7.0 15.4 16.4 27.2 13.2 27.1 25.5 28.8 56.6 48.3 23.2 45.0 22.9 26.6 23.3 1.5 15.4 13.1 24.2 29.7 74.2 4.7 22.6 28.1 32.7 29.8 15.4 17.1 69.7 4.9 28.5 1.8 14.6 36.6 15.4 70.0 33.7 42.6 32.2 43.4 17.8 19.6 45.5 24.5 12.5 5.2 21.5 21.4 35.9 7.5 12.1 31.3 22.0 0.6 144.1 69.9 72.9 37.2 131.9 22.5 5.8 5.6 47.5 30.0 15.1 59.9 17.4 40.2 73.2 17.4 59.2 18.9 28.4 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.6 0.9 0.1 0.0 0.3 0.4 0.0 0.0 0.0 0.1 0.0 0.2 22.8 33.2 38.6 174.5 48.3 12.2 48.7 0.0 33.1 0.0 6.8 27.2 24.3 25.6 70.7 34.0 1.2 11.6 10.1 8.4 12.5 131.0 10.5 8.0 15.2 1.5 9.2 3.7 156.4 2.7 1.1 0.5 7.9 13.1 2.2 8.3 14.7 28.9 45.6 4.0 243.2 8.4 5.9 18.7 3.1 7.0 5.1 5.0 26.7 1.4 4.4 84.1 157.5 10.2 8.2 2.5 5.6 2.2 20.5 3.0 10.6 45.0 0.6 27.0 0.0 61.3 39.0 5.3 0.0 44.4 1.6 10.8 0.1 8.9 15.9 155.6 13.1 9.5 11.2 40.6 16.9 2.9 7.5 24.5 2.3 17.7 0.9 7.1 SURF1 ENSG00000148290 "SURF1 cytochrome c oxidase assembly factor" Q15526 9 133351758-133356676 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Charcot-Marie-Tooth disease, Disease variant, Leigh syndrome, Neurodegeneration, Neuropathy, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB033946 Uncertain NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 29: Non-specific - Vesicular transport" "Cluster 21: OE19 - Mitochondria" "Cluster 39: Non-specific - Basic cellular processes" "CAB033946: AB_2302648" "unprognostic (1.87e-1)" "unprognostic (7.76e-3)" "unprognostic (1.34e-2)" "unprognostic (4.26e-3)" "unprognostic (3.43e-1)" "unprognostic (2.58e-1)" "unprognostic (1.35e-1)" "unprognostic (7.68e-2)" "unprognostic (3.00e-1)" "unprognostic (4.75e-2)" "unprognostic (1.11e-2)" "unprognostic (2.66e-1)" "prognostic favorable (6.92e-9)" "unprognostic (3.91e-2)" "unprognostic (2.13e-1)" "unprognostic (4.58e-2)" "unprognostic (1.98e-1)" 41.8 54.3 31.8 9.8 32.9 16.8 39.9 32.3 41.3 33.6 34.2 53.8 18.8 32.8 38.5 34.9 34.5 12.7 70.6 31.0 31.8 59.0 93.1 33.4 16.7 31.9 32.3 31.7 79.4 34.8 41.2 11.9 31.7 42.5 20.8 8.9 42.4 21.4 80.2 41.4 41.1 13.8 32.1 39.9 65.4 33.9 33.8 20.3 43.7 41.2 21.8 45.6 31.8 32.4 9.6 21.8 16.5 23.5 39.7 22.0 35.6 11.5 27.8 18.9 16.5 29.6 32.6 13.0 16.3 18.2 27.6 27.8 20.4 27.6 15.0 23.8 13.3 13.2 31.5 23.4 46.9 21.1 13.5 26.3 47.8 13.2 32.1 23.1 14.9 33.2 13.7 26.3 21.0 42.4 26.7 21.8 18.6 86.9 22.1 18.2 24.7 40.8 31.4 20.4 16.2 45.0 26.2 34.2 30.6 22.4 50.1 15.8 12.2 23.3 14.3 16.1 11.6 32.2 51.9 16.3 22.1 10.3 24.0 10.7 11.6 24.1 6.6 7.8 7.9 23.9 9.8 9.0 10.2 19.3 14.0 7.7 11.1 6.5 7.1 13.4 14.9 5.6 31.8 32.9 32.3 41.3 31.0 31.8 31.9 32.3 31.7 32.1 33.8 32.4 46.2 28.9 29.6 5.2 55.6 46.5 54.9 56.1 43.3 24.4 85.5 97.3 94.6 75.8 44.0 68.0 6.2 93.4 55.7 114.0 137.0 90.4 48.3 54.5 25.2 36.8 53.8 32.2 4.8 101.0 87.5 38.3 41.8 36.9 22.9 44.3 50.3 158.1 101.1 28.6 5.6 74.3 99.7 93.2 83.6 127.1 52.2 60.3 69.4 4.7 96.9 95.2 62.8 4.5 10.4 71.9 102.1 48.2 74.3 56.1 215.0 174.5 45.1 25.3 32.9 41.5 56.6 66.2 94.4 50.4 49.0 80.6 51.5 52.6 79.6 63.4 SYN1 MRX50 ENSG00000008056 "Synapsin I" P17600 X 47571901-47619857 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" Actin-binding Epilepsy "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "brain: 271.3" "Cell type enhanced" "Detected in many" "Bipolar cells: 27.1;Excitatory neurons: 37.3;Horizontal cells: 28.6;Inhibitory neurons: 34.1" "Cancer enriched" "Detected in many" 4 "glioma: 11.2" "Group enriched" "Detected in many" 5 "amygdala: 81.4;basal ganglia: 127.5;cerebral cortex: 271.3;hippocampal formation: 118.3;white matter: 150.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HaCaT: 9.0;HHSteC: 8.1;NTERA-2: 17.4;SCLC-21H: 30.2;SH-SY5Y: 7.9;SuSa: 7.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000397, CAB021929" Enhanced NA NA 48000 "Cluster 10: Brain - Neuronal signaling" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 41: Macrophages - Immune response" "CAB021929: , HPA000397: AB_1080146" "unprognostic (1.22e-1)" "unprognostic (9.25e-2)" "unprognostic (2.16e-3)" "unprognostic (4.48e-3)" "unprognostic (3.05e-3)" "unprognostic (7.57e-2)" "unprognostic (1.63e-1)" "unprognostic (4.31e-1)" "unprognostic (3.49e-2)" "unprognostic (6.68e-2)" "unprognostic (3.97e-3)" "unprognostic (1.32e-1)" "unprognostic (2.64e-4)" "unprognostic (2.73e-3)" "unprognostic (5.79e-2)" "unprognostic (2.95e-3)" "unprognostic (5.27e-2)" 3.9 11.0 81.4 3.5 127.5 2.0 0.9 9.0 271.3 1.2 0.0 3.7 0.6 1.3 1.4 0.7 1.9 2.6 15.3 118.3 30.7 2.2 3.0 2.9 0.4 28.5 2.3 2.9 2.2 0.7 35.7 4.4 12.7 2.3 1.8 44.0 1.2 1.7 1.9 1.3 1.8 1.7 0.0 1.1 1.9 2.6 9.9 0.9 0.5 3.8 0.7 4.1 1.6 150.4 0.0 0.0 5.0 0.7 0.2 1.0 0.0 0.9 0.2 1.4 0.4 0.0 0.0 0.0 1.6 0.1 1.6 9.0 0.5 0.0 0.4 0.6 0.1 0.5 0.0 0.0 8.1 0.0 2.1 1.9 0.0 1.5 0.3 0.0 0.1 0.7 0.6 0.3 0.2 0.2 0.3 0.3 17.4 0.0 0.1 0.1 0.1 0.3 0.0 0.0 30.2 7.9 0.0 0.1 0.1 7.2 2.2 0.0 0.2 0.0 0.9 0.1 0.1 0.2 0.1 0.0 0.7 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 81.4 127.5 9.0 271.3 118.3 30.7 28.5 2.3 12.7 0.0 9.9 150.4 0.2 0.0 0.0 5.5 0.0 0.9 0.6 0.6 0.6 27.1 0.2 0.1 3.7 1.5 0.1 0.0 10.4 0.1 0.0 0.4 0.0 0.1 0.2 0.0 0.6 0.4 4.2 0.8 37.3 0.7 0.0 2.7 1.1 0.1 0.0 1.6 3.3 1.5 0.2 28.6 34.1 0.3 2.0 1.6 3.4 1.0 2.8 5.1 0.0 7.5 4.7 6.4 0.0 10.6 5.1 0.6 0.2 3.4 0.0 1.2 0.0 0.1 0.1 7.3 6.6 0.8 2.1 3.6 2.1 0.0 0.6 0.0 0.1 3.2 0.5 0.3 SYNE1 "8B, ARCA1, C6orf98, CPG2, dJ45H2.2, enaptin, KIAA0796, MYNE1, Nesp1, Nesprin-1, SCAR8, SYNE-1B" ENSG00000131018 "Spectrin repeat containing nuclear envelope protein 1" Q8NF91 6 152121684-152637801 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Differentiation, Spermatogenesis" Actin-binding "Cancer-related genes, Disease variant, Emery-Dreifuss muscular dystrophy, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 152.5;choroid plexus: 182.9" "Cell type enhanced" "Detected in many" "Astrocytes: 550.1;Bipolar cells: 332.1;Excitatory neurons: 494.6;Inhibitory neurons: 482.6;Microglial cells: 315.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 4 "eosinophil: 56.8" "Lineage enriched" "Detected in all" 4 "granulocytes: 56.8" "Cell line enhanced" "Detected in many" "U-2 OS: 29.8;U-266/70: 29.1" "Low region specificity" "Detected in all" HPA019113 Approved Supported "Nucleoplasm,Nuclear membrane" NA NA 72000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 43: Cardiomyocytes - Nuclear processes" "Nucleoplasm, Nuclear membrane" "HPA019113: AB_1857707" "unprognostic (9.99e-2)" "unprognostic (1.91e-1)" "unprognostic (2.22e-2)" "unprognostic (1.75e-1)" "unprognostic (2.28e-1)" "unprognostic (9.58e-3)" "unprognostic (1.11e-1)" "unprognostic (3.55e-3)" "unprognostic (1.58e-1)" "unprognostic (9.85e-2)" "unprognostic (8.87e-3)" "unprognostic (2.70e-1)" "unprognostic (4.14e-3)" "unprognostic (5.83e-2)" "unprognostic (1.82e-1)" "unprognostic (1.42e-1)" "unprognostic (2.78e-1)" 15.4 17.8 60.2 7.5 68.8 53.6 14.4 152.5 70.2 18.9 182.9 17.2 2.3 19.1 23.7 5.6 26.4 7.9 32.3 92.4 58.1 34.7 14.6 31.3 17.1 55.0 58.8 44.5 20.6 23.6 56.8 4.4 55.6 17.0 6.2 66.3 5.0 12.6 28.0 19.6 11.4 13.1 38.3 32.9 21.6 17.6 55.4 23.9 44.7 16.5 13.4 16.3 12.9 51.5 0.2 5.8 3.7 4.4 5.7 12.1 1.5 14.7 6.9 3.4 6.0 1.3 0.2 13.5 0.7 7.5 11.2 0.3 1.6 3.8 3.5 11.6 4.0 5.2 4.1 4.0 12.8 1.1 2.7 7.9 0.8 7.5 14.9 9.2 6.8 6.9 0.0 14.2 9.2 0.7 2.4 0.2 0.9 1.3 2.2 2.9 8.1 3.5 15.7 0.2 2.6 3.9 2.7 0.8 9.8 3.7 0.8 0.5 9.0 16.3 29.8 5.9 7.6 29.1 12.5 23.3 8.8 2.9 4.6 10.2 2.3 56.8 11.8 1.8 7.9 6.9 10.3 13.4 1.8 8.2 9.7 10.9 1.6 9.9 3.9 1.5 13.2 3.5 60.2 68.8 152.5 70.2 92.4 58.1 55.0 58.8 55.6 38.3 55.4 51.5 139.7 166.7 215.2 550.1 29.1 12.7 5.4 3.0 3.4 332.1 4.9 9.7 117.2 7.2 53.1 44.1 200.1 0.9 132.9 0.4 3.9 24.0 11.5 132.0 118.2 127.5 3.0 11.6 494.6 7.7 14.2 79.6 7.7 17.8 15.2 13.1 90.0 21.8 8.0 138.0 482.6 11.5 2.0 10.1 15.0 12.6 33.2 16.0 16.0 315.7 12.8 27.3 210.1 256.4 108.6 4.2 0.1 39.9 79.6 5.1 0.0 17.8 146.7 145.5 26.3 145.8 85.6 3.9 5.7 2.2 9.7 1.2 74.7 62.2 0.4 2.2 SYNE4 "C19orf46, DFNB76, FLJ36445, Nesp4, Nesprin-4" ENSG00000181392 "Spectrin repeat containing nuclear envelope family member 4" Q8N205 19 36003307-36008813 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Breast glandular cells: 32.0;Breast myoepithelial cells: 35.9;Cytotrophoblasts: 32.6;Syncytiotrophoblasts: 33.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "CACO-2: 32.5;Hep G2: 29.1;MCF7: 34.2;SK-BR-3: 40.1;T-47d: 31.0" "Region enriched" "Detected in single" 15 "cerebellum: 6.8" "Not detected" "Not detected" HPA060253 Uncertain NA NA "Cluster 1: Thyroid gland - Transcription" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 35: Glandular cells - Unknown function" "HPA060253: AB_2684233" "unprognostic (8.54e-2)" "unprognostic (6.48e-2)" "unprognostic (1.32e-2)" "unprognostic (1.24e-1)" "unprognostic (5.54e-2)" "unprognostic (2.42e-3)" "unprognostic (3.76e-2)" "unprognostic (2.03e-2)" "unprognostic (1.93e-1)" "unprognostic (3.15e-2)" "unprognostic (3.36e-3)" "unprognostic (6.02e-2)" "prognostic favorable (8.64e-9)" "unprognostic (1.25e-1)" "unprognostic (2.54e-2)" "unprognostic (4.50e-1)" "unprognostic (1.97e-2)" 0.2 0.2 1.2 0.2 1.0 0.2 5.2 6.7 1.5 2.6 2.5 1.9 3.2 0.7 7.7 1.2 3.9 1.6 0.2 0.7 2.9 8.4 12.0 3.1 0.2 3.7 3.0 0.3 5.4 12.1 12.7 1.6 3.6 10.9 1.4 0.2 9.2 4.0 0.3 1.1 1.3 0.2 1.3 0.3 3.4 0.2 2.5 1.7 8.6 0.0 0.3 0.8 1.3 1.2 0.3 0.3 0.2 0.4 0.1 0.2 4.3 0.0 0.0 0.0 0.1 32.5 3.8 0.3 0.4 0.0 0.2 0.0 0.3 0.4 0.0 1.1 0.5 0.1 0.8 29.1 0.5 0.0 0.2 0.2 0.2 1.1 0.0 0.0 0.2 1.6 0.4 0.4 0.0 34.2 0.5 0.1 0.2 0.3 0.2 0.9 0.0 0.4 2.2 1.0 5.0 0.0 0.0 40.1 0.2 0.2 31.0 0.3 0.0 0.3 0.6 0.5 0.2 0.5 0.7 0.6 0.3 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 1.0 6.7 1.5 0.7 2.9 3.7 3.0 3.6 1.3 2.5 1.2 0.3 6.4 17.5 0.3 0.7 0.5 14.9 19.9 5.2 0.9 32.0 35.9 0.4 24.3 20.2 29.5 4.2 32.6 0.8 5.4 25.4 21.2 0.0 9.1 1.0 0.8 29.8 0.0 0.6 8.6 24.7 0.7 8.2 10.7 1.3 0.5 0.7 12.5 2.6 0.0 0.9 10.6 26.4 0.6 0.5 0.0 0.0 0.4 0.0 0.0 0.0 0.3 0.0 0.0 0.9 11.7 16.9 0.0 0.0 23.9 4.5 24.2 17.3 0.4 0.0 0.3 1.6 0.1 0.4 2.1 0.4 33.9 1.2 0.1 8.8 9.2 SYNJ1 "INPP5G, PARK20" ENSG00000159082 "Synaptojanin 1" O43426 21 32628759-32728040 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Endocytosis "Hydrolase, RNA-binding" "Disease variant, Epilepsy, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 45.9;retina: 48.4" "Cell type enhanced" "Detected in many" "Excitatory neurons: 110.9;Inhibitory neurons: 91.5;Oligodendrocytes: 61.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011916 Enhanced Approved Nucleoplasm,Centrosome,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 58: Brain - Synaptic function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoplasm, Cytosol" Centrosome "HPA011916: AB_1857692" "unprognostic (6.84e-2)" "unprognostic (8.64e-2)" "unprognostic (5.76e-2)" "unprognostic (6.44e-2)" "unprognostic (1.27e-1)" "prognostic favorable (4.43e-4)" "unprognostic (1.45e-1)" "unprognostic (3.73e-3)" "unprognostic (1.63e-1)" "unprognostic (6.22e-3)" "unprognostic (1.84e-2)" "prognostic unfavorable (2.58e-4)" "unprognostic (1.28e-1)" "unprognostic (6.36e-2)" "unprognostic (5.97e-2)" "unprognostic (1.79e-1)" "unprognostic (2.92e-1)" 7.6 6.9 15.0 5.3 22.8 23.8 6.5 1.1 45.9 6.2 3.5 5.6 4.0 5.1 5.1 4.6 5.0 5.2 6.4 22.1 9.8 7.4 5.7 8.0 6.3 19.5 5.6 4.8 4.8 8.4 13.8 9.8 14.8 4.5 5.4 48.4 4.7 3.7 7.7 5.1 6.3 4.9 0.0 7.9 5.0 10.2 8.7 7.1 7.3 6.4 4.8 5.5 5.4 25.9 5.5 2.9 5.0 5.7 8.9 7.1 10.3 11.3 6.2 6.8 5.7 6.1 2.6 2.0 3.8 6.9 8.9 5.0 8.9 6.8 8.4 6.8 8.1 13.8 8.7 3.5 4.8 5.6 11.7 4.1 4.9 12.0 6.1 5.8 10.8 7.3 10.6 11.6 9.0 5.5 5.5 5.1 3.4 6.4 6.0 6.1 11.1 7.4 7.5 4.3 5.6 4.5 14.0 8.4 5.6 6.9 7.8 7.2 11.2 10.0 5.3 8.2 6.4 6.0 7.8 4.4 8.0 10.7 8.7 3.4 2.9 6.9 1.2 5.2 2.0 0.1 1.9 2.0 2.5 0.3 2.2 2.2 9.1 0.5 4.7 1.4 2.6 1.1 15.0 22.8 1.1 45.9 22.1 9.8 19.5 5.6 14.8 0.0 8.7 25.9 10.2 6.4 5.4 22.9 3.9 4.8 1.9 3.1 8.0 24.8 3.8 2.5 10.0 2.8 4.0 1.8 45.9 17.7 7.0 4.8 5.9 2.0 19.9 2.4 4.7 11.9 3.0 5.0 110.9 1.3 9.8 5.3 4.1 3.6 3.8 2.2 11.0 4.2 10.1 10.1 91.5 2.0 0.0 18.6 5.7 11.3 2.8 15.7 1.8 31.9 6.5 21.8 4.1 49.3 61.0 2.8 5.3 4.5 8.6 2.7 6.2 6.5 4.6 45.4 6.6 6.1 5.8 22.1 13.3 6.7 3.3 38.0 9.9 2.8 5.4 4.3 SYT14 "FLJ34198, sytXIV" ENSG00000143469 "Synaptotagmin 14" Q8NB59 1 209900923-210171389 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "brain: 7.0;retina: 1.9;testis: 3.2;thyroid gland: 5.0" "Cell type enhanced" "Detected in some" "Excitatory neurons: 208.7;Inhibitory neurons: 213.9;Oligodendrocyte precursor cells: 152.8;Oligodendrocytes: 197.6" "Cancer enhanced" "Detected in some" "thyroid cancer: 1.9" "Region enriched" "Detected in some" 4 "cerebellum: 7.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ hTERT+: 9.7;GAMG: 6.7;hTERT-HME1: 4.7;SCLC-21H: 6.5;U-138 MG: 6.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036963 Supported Vesicles NA NA "Cluster 21: Non-specific - Transcription" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles "HPA036963: AB_10670378" "unprognostic (1.38e-4)" "unprognostic (8.62e-3)" "unprognostic (1.93e-1)" "unprognostic (3.90e-4)" "unprognostic (1.97e-1)" "unprognostic (4.43e-5)" "unprognostic (1.92e-1)" "unprognostic (1.88e-2)" "unprognostic (6.85e-2)" "unprognostic (1.56e-2)" "unprognostic (3.81e-1)" "unprognostic (4.85e-3)" "unprognostic (2.30e-4)" "unprognostic (1.61e-1)" "unprognostic (1.76e-1)" "unprognostic (3.33e-3)" 0.0 0.7 0.4 0.0 0.6 0.0 0.0 7.0 1.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.3 0.0 0.0 0.0 0.0 0.4 0.2 0.0 0.2 0.0 0.6 0.0 0.4 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 3.2 0.2 0.0 5.0 0.0 0.0 0.0 0.0 1.6 2.1 0.0 0.0 0.0 0.0 0.0 0.0 2.5 9.7 2.2 1.2 0.0 0.0 0.0 0.0 0.1 6.7 3.0 0.0 0.0 2.2 0.0 0.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 1.4 4.7 1.1 0.0 0.0 0.0 0.0 4.1 0.0 0.0 0.0 3.6 0.0 0.3 0.0 0.0 0.0 0.0 1.9 6.5 2.0 0.0 0.0 3.6 0.8 0.0 0.0 1.6 6.4 3.2 0.0 0.9 0.0 0.0 0.0 0.2 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.6 7.0 1.0 0.4 0.3 0.4 0.2 0.4 0.1 0.2 1.6 0.0 0.0 0.0 30.3 0.0 0.0 0.1 0.0 0.0 30.1 0.2 0.0 2.2 0.0 0.0 0.0 27.1 0.0 0.0 0.0 3.9 0.3 17.0 11.6 2.9 0.2 0.0 0.0 208.7 0.6 0.0 0.2 0.0 29.3 0.0 0.9 0.0 0.0 0.0 52.2 213.9 0.0 0.0 0.0 0.0 5.0 0.6 0.2 0.0 3.7 0.0 1.6 0.0 152.8 197.6 0.3 0.0 0.0 0.0 0.7 0.0 0.4 0.0 29.4 0.0 0.9 0.2 6.0 16.8 0.0 0.0 0.0 0.1 0.7 0.0 0.2 SYT2 ENSG00000143858 "Synaptotagmin 2" Q8N9I0 1 202590596-202710454 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins" Differentiation "Congenital myasthenic syndrome, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 14 "brain: 73.4" "Cell type enhanced" "Detected in some" "Excitatory neurons: 23.2;Inhibitory neurons: 22.7;Oligodendrocytes: 7.4" "Cancer enriched" "Detected in some" 7 "testis cancer: 3.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "AF22: 8.5;NTERA-2: 5.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA063655 Enhanced Supported NA NA "Cluster 70: Brain - Nervous system development" "Cluster 12: NES - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA063655: AB_2685077" "unprognostic (1.32e-2)" "unprognostic (4.99e-2)" "unprognostic (4.89e-2)" "unprognostic (1.03e-2)" "unprognostic (2.21e-1)" "unprognostic (2.24e-2)" "unprognostic (3.00e-1)" "unprognostic (2.35e-3)" "unprognostic (8.81e-3)" "unprognostic (1.17e-1)" "unprognostic (1.53e-2)" "unprognostic (6.33e-2)" "unprognostic (1.56e-2)" "unprognostic (6.23e-2)" "unprognostic (3.26e-1)" "unprognostic (2.54e-1)" "unprognostic (5.17e-3)" 0.2 1.3 2.6 0.2 8.8 0.0 0.1 46.3 73.4 0.2 0.3 0.3 0.2 0.4 0.8 0.0 0.2 0.2 0.3 0.5 16.8 0.0 0.0 0.0 0.1 66.0 17.5 0.6 0.0 0.0 0.0 0.0 68.3 0.1 0.1 5.2 0.2 0.0 0.2 0.1 0.2 0.0 13.9 0.2 0.1 0.5 23.1 0.0 0.0 0.0 0.0 0.2 0.1 20.7 0.0 0.1 8.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.1 1.1 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 5.8 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.6 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 2.6 8.8 46.3 73.4 0.5 16.8 66.0 17.5 68.3 13.9 23.1 20.7 0.2 0.0 0.0 2.6 0.1 0.5 1.6 1.1 0.0 3.6 0.2 0.1 2.9 0.0 0.5 0.0 0.0 0.3 0.0 0.4 0.0 0.0 0.2 0.6 1.7 0.3 0.0 0.0 23.2 0.0 0.1 0.3 0.0 2.0 0.0 0.9 0.0 0.0 0.0 3.3 22.7 0.1 0.0 0.0 0.0 0.5 3.4 0.2 0.0 1.0 0.1 1.2 0.0 1.0 7.4 0.0 0.0 1.9 0.0 0.4 0.0 0.1 0.7 5.1 0.0 0.3 0.6 0.3 0.9 0.0 0.6 0.1 0.1 0.1 0.4 2.2 SZT2 "C1orf84, FLJ10387, FLJ34502, KIAA0467, RP11-506B15.1, SZT2A, SZT2B" ENSG00000198198 "SZT2 subunit of KICSTOR complex" Q5T011 1 43389882-43454247 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 62.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029012 Approved Approved "Nucleoplasm,Vesicles,Actin filaments" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 20: HeLa - Mitochondria" "Cluster 9: Photoreceptor cells - Phototransduction" "Nucleoplasm, Vesicles, Actin filaments" "HPA029012: AB_10600817" "unprognostic (1.35e-1)" "unprognostic (2.55e-1)" "unprognostic (4.14e-1)" "unprognostic (6.61e-2)" "unprognostic (1.29e-1)" "prognostic favorable (1.47e-7)" "prognostic unfavorable (2.53e-4)" "prognostic favorable (6.20e-4)" "unprognostic (1.54e-1)" "unprognostic (1.81e-2)" "unprognostic (5.96e-2)" "unprognostic (1.03e-1)" "unprognostic (1.05e-2)" "unprognostic (1.84e-3)" "unprognostic (8.28e-2)" "unprognostic (7.19e-2)" "unprognostic (2.61e-2)" 6.3 5.3 1.3 4.3 2.5 6.0 6.2 3.2 3.1 6.1 0.8 6.7 3.4 7.2 2.6 5.9 7.0 2.7 5.4 1.1 2.1 4.7 4.4 6.4 4.2 2.9 2.3 8.0 6.5 5.6 8.8 2.7 2.5 6.5 3.4 4.0 6.5 3.2 6.6 7.7 7.9 3.6 0.9 7.1 6.4 9.6 3.0 4.4 9.0 3.9 4.1 6.2 5.8 5.0 4.5 4.4 3.7 3.4 9.1 4.5 5.7 3.7 4.4 4.5 4.1 1.5 5.0 4.1 4.1 5.9 3.2 5.1 3.7 6.3 3.9 5.1 3.4 7.5 8.1 2.7 3.4 6.1 6.2 4.8 4.2 7.7 7.5 5.0 5.2 4.7 3.4 6.8 3.2 2.1 4.1 1.6 3.3 2.7 4.5 4.5 5.1 4.9 2.6 6.2 3.8 3.4 7.8 5.9 4.0 4.8 3.2 8.8 6.5 4.8 6.8 6.4 6.5 7.3 2.8 3.4 4.9 3.8 3.1 1.4 0.5 1.4 0.3 0.4 0.8 0.3 0.1 0.1 0.4 0.3 0.4 0.3 1.1 0.3 0.5 0.9 0.4 0.2 1.3 2.5 3.2 3.1 1.1 2.1 2.9 2.3 2.5 0.9 3.0 5.0 8.3 25.6 19.3 19.6 10.5 1.9 3.5 5.1 6.2 16.8 7.7 7.0 4.8 5.7 6.8 5.5 62.6 6.5 9.2 10.0 0.0 6.1 14.2 5.8 10.1 7.6 3.6 5.5 20.4 6.4 5.2 7.0 13.7 6.9 14.5 19.0 12.8 13.1 5.4 13.5 20.2 7.0 4.1 7.0 3.1 15.8 9.3 9.4 5.4 15.9 11.6 5.8 13.4 11.1 29.1 6.8 3.7 6.0 9.5 4.2 10.5 9.2 8.0 22.2 19.7 9.1 7.1 8.1 8.6 4.2 1.8 5.5 11.4 12.6 7.0 3.8 TACSTD2 "EGP-1, GA733-1, M1S1, TROP2" ENSG00000184292 "Tumor associated calcium signal transducer 2" P09758 1 58575433-58577252 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins" "Sensory transduction, Vision" "Tumor antigen" "Amyloidosis, Corneal dystrophy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 989.6;salivary gland: 468.5;skin 1: 438.8" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 6559.0;Basal respiratory cells: 3141.0;Club cells: 2499.0;Prostatic glandular cells: 3724.1;Squamous epithelial cells: 2716.6;Urothelial cells: 8102.8" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Immune cell enhanced" "Detected in some" "eosinophil: 15.0" "Group enriched" "Detected in many" 79 "dendritic cells: 4.3;granulocytes: 15.0;monocytes: 4.2" "Cell line enhanced" "Detected in many" "A-431: 766.6;CAPAN-2: 1005.9;HaCaT: 1010.0;RT4: 355.3" "Not detected" "Not detected" "Low region specificity" "Detected in some" "HPA043104, HPA055067, CAB072852" Enhanced Supported "Nucleoli,Vesicles,Plasma membrane" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 22: Epithelial cell types - Mixed function" "Plasma membrane" "Nucleoli, Vesicles" "CAB072852: , HPA043104: AB_10960710, HPA055067: AB_2682687" "unprognostic (1.80e-2)" "unprognostic (3.08e-1)" "unprognostic (3.67e-3)" "unprognostic (1.22e-1)" "unprognostic (5.70e-2)" "unprognostic (2.15e-2)" "unprognostic (1.19e-1)" "unprognostic (1.79e-1)" "unprognostic (1.99e-1)" "unprognostic (1.03e-2)" "unprognostic (1.71e-2)" "unprognostic (7.91e-2)" "prognostic favorable (3.99e-4)" "unprognostic (7.10e-2)" "unprognostic (2.55e-1)" "unprognostic (6.91e-3)" "unprognostic (2.50e-1)" 4.8 1.2 0.2 1.3 0.4 13.5 135.8 0.2 0.4 218.6 1.9 1.1 0.7 19.1 25.3 989.6 27.7 13.0 0.8 0.3 0.3 137.9 4.0 71.2 1.0 0.2 0.3 1.5 81.1 3.5 2.4 17.7 0.2 126.8 0.9 0.0 468.5 97.1 1.9 438.8 1.2 2.0 0.2 1.0 65.7 0.5 0.3 9.2 5.0 0.3 180.0 234.6 375.0 0.6 766.6 0.1 0.0 1.5 0.0 0.0 280.1 0.2 0.0 0.0 0.1 0.7 1005.9 0.1 94.7 64.2 0.1 1010.0 0.0 186.5 0.0 0.7 0.0 0.2 19.7 0.3 0.3 0.1 0.8 0.2 274.5 0.4 11.3 0.0 42.5 0.0 0.2 1.3 0.0 166.3 0.6 1.1 0.5 167.0 1.4 0.2 0.1 0.6 137.0 355.3 0.2 0.3 32.4 264.9 1.0 3.2 173.6 1.5 45.4 1.0 1.7 0.8 1.7 0.4 0.9 0.7 1.0 0.3 0.7 0.0 4.2 15.0 0.0 0.1 0.0 0.0 0.0 0.0 4.3 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 1.8 0.2 0.4 0.2 0.4 0.3 0.3 0.2 0.3 0.2 0.2 0.3 0.6 9.0 346.1 109.2 0.0 3.1 1490.5 6559.0 3141.0 1226.5 0.0 789.8 445.6 0.4 338.8 2499.0 1278.2 0.0 107.1 9.1 2.8 43.0 2165.2 0.0 482.3 48.6 60.4 0.0 0.0 0.1 1263.4 8.1 36.3 143.2 608.7 8.8 0.2 1.4 0.5 8.8 0.0 0.0 8.5 1143.4 0.8 203.4 0.0 0.0 34.8 113.8 0.0 31.3 0.0 0.0 0.0 0.6 1778.0 3.6 0.0 1.4 3724.1 0.2 3.4 1080.4 0.0 0.0 1.3 142.4 0.4 1.1 2716.6 1531.8 78.4 32.8 0.0 1.5 8102.8 TAF1 "BA2R, CCG1, CCGS, DYT3, DYT3/TAF1, KAT4, NSCL2, TAF2A, TAFII250" ENSG00000147133 "TATA-box binding protein associated factor 1" P21675 X 71366264-71532374 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Cell cycle, Host-virus interaction, Transcription, Transcription regulation" "Acyltransferase, DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Dystonia, Mental retardation, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 81.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "HPA001075, CAB016283" Supported Supported Nucleoplasm NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 32: U-937 - Innate immune response" "Cluster 9: Photoreceptor cells - Phototransduction" Nucleoplasm "CAB016283: AB_671202, HPA001075: AB_1080179" "unprognostic (2.95e-2)" "unprognostic (1.77e-1)" "unprognostic (6.45e-3)" "unprognostic (1.91e-2)" "unprognostic (1.88e-2)" "unprognostic (1.23e-1)" "unprognostic (1.44e-1)" "prognostic favorable (6.54e-4)" "unprognostic (2.68e-2)" "unprognostic (3.43e-2)" "unprognostic (2.03e-1)" "unprognostic (5.59e-2)" "prognostic unfavorable (6.03e-4)" "unprognostic (1.14e-2)" "unprognostic (1.41e-1)" "unprognostic (1.82e-2)" "unprognostic (2.56e-2)" 10.9 8.6 10.3 11.4 12.7 12.8 12.3 13.7 11.1 11.1 10.2 10.0 6.6 13.8 12.9 7.5 11.1 7.8 7.0 9.3 14.1 7.5 7.8 9.1 14.1 11.5 11.3 14.4 9.8 12.2 8.4 10.0 10.9 10.0 10.0 27.3 7.7 10.1 10.5 13.3 9.3 10.9 8.2 15.4 10.6 7.2 12.5 14.8 12.7 10.3 12.4 9.2 8.6 16.8 18.6 15.9 18.2 12.4 14.6 23.2 11.0 13.3 12.1 13.7 11.1 12.3 11.3 17.6 11.5 14.9 12.3 17.5 24.1 11.0 17.0 11.2 21.9 20.1 22.1 13.1 11.1 39.7 19.4 14.1 11.3 14.2 27.2 12.8 14.7 13.2 28.2 41.1 14.4 14.5 22.4 25.4 20.9 23.5 20.8 19.8 35.8 21.6 11.1 25.0 9.0 14.5 37.7 13.6 18.7 14.3 9.6 22.9 18.6 16.5 14.2 13.4 9.7 17.5 17.4 21.4 9.0 33.2 12.5 1.6 1.4 0.7 1.4 0.9 1.3 1.0 1.4 1.4 1.5 1.5 1.6 1.8 1.8 1.5 1.6 1.4 1.0 0.7 10.3 12.7 13.7 11.1 9.3 14.1 11.5 11.3 10.9 8.2 12.5 16.8 26.7 32.1 26.7 44.7 21.2 11.9 8.9 10.4 18.2 37.5 12.5 13.3 17.2 10.0 23.9 3.7 81.3 8.6 21.5 7.8 1.9 6.3 2.5 17.0 23.4 24.6 11.4 28.6 54.3 7.0 5.9 17.6 12.2 18.9 23.4 23.9 18.9 12.6 8.8 16.8 52.2 14.6 6.1 16.2 20.0 2.6 22.1 20.4 5.4 47.8 23.9 17.0 29.9 49.3 79.1 7.6 13.3 22.2 18.7 11.2 13.4 5.2 14.8 67.9 0.0 27.4 18.0 9.3 10.7 17.8 17.3 5.7 23.8 25.9 13.6 9.6 TARDBP "ALS10, TDP-43" ENSG00000120948 "TAR DNA binding protein" Q13148 1 11012344-11030528 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Biological rhythms, mRNA processing, mRNA splicing, Transcription, Transcription regulation" "DNA-binding, Repressor, RNA-binding" "Amyotrophic lateral sclerosis, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003703, HPA017284" Supported Enhanced Nucleoplasm NA NA 29000 "Cluster 27: Non-specific - Gene expression" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "CAB003703: AB_425904, HPA017284: AB_1857775" "unprognostic (3.72e-3)" "prognostic favorable (1.15e-5)" "unprognostic (1.06e-1)" "unprognostic (1.22e-1)" "unprognostic (8.52e-2)" "unprognostic (4.10e-2)" "prognostic unfavorable (1.20e-7)" "unprognostic (1.06e-1)" "unprognostic (3.41e-3)" "unprognostic (4.75e-3)" "unprognostic (2.24e-1)" "unprognostic (2.54e-2)" "unprognostic (2.27e-3)" "unprognostic (2.27e-1)" "unprognostic (1.87e-1)" "unprognostic (2.86e-1)" "unprognostic (2.71e-2)" 83.4 80.1 71.9 87.1 80.6 69.7 83.3 84.7 79.0 93.9 78.1 94.5 77.4 90.9 78.8 111.1 84.1 58.7 93.0 69.4 78.5 93.8 105.5 91.6 106.5 75.5 77.2 103.5 77.2 86.7 89.1 82.7 76.4 90.1 94.5 119.9 86.6 78.8 138.9 96.1 94.5 81.2 74.8 97.4 82.4 68.2 74.7 115.1 96.6 102.9 122.9 87.6 95.8 86.0 244.7 164.4 270.4 143.5 143.9 118.2 160.3 164.7 142.3 263.6 195.5 187.9 175.6 316.3 118.1 180.6 154.3 169.2 333.1 187.6 336.0 175.1 153.8 241.2 275.2 257.9 119.4 290.5 158.9 99.5 211.4 184.5 147.9 143.8 188.6 126.7 319.0 176.4 221.7 195.0 215.6 228.6 221.0 232.2 141.7 256.9 214.4 206.2 186.0 179.1 187.9 150.8 221.3 173.7 128.8 197.1 173.8 200.9 174.8 173.8 207.8 146.3 236.9 133.3 176.2 336.3 116.2 288.2 192.0 38.0 38.0 33.7 46.7 48.6 57.4 55.2 46.9 45.4 61.7 39.6 46.3 50.5 15.4 67.2 50.0 43.1 54.3 36.4 71.9 80.6 84.7 79.0 69.4 78.5 75.5 77.2 76.4 74.8 74.7 86.0 35.5 32.1 74.4 29.4 57.6 114.6 89.9 40.8 52.3 37.6 52.0 38.6 68.0 31.5 57.0 29.5 29.2 63.2 46.3 54.2 33.2 50.8 9.7 50.7 50.0 54.9 66.3 63.5 29.5 54.2 84.5 45.2 34.7 61.7 42.3 45.8 40.0 51.7 50.1 37.0 29.8 50.1 38.7 45.9 46.3 12.3 47.2 37.8 35.6 23.4 54.3 36.2 35.0 37.2 57.2 52.9 36.1 51.6 48.8 71.7 43.2 43.9 54.4 38.8 32.9 42.8 56.9 64.9 32.8 52.4 114.5 73.5 41.3 23.6 52.6 71.3 TBC1D24 "DFNA65, DFNB86, KIAA1171, TLDC6" ENSG00000162065 "TBC1 domain family member 24" Q9ULP9 16 2475051-2509560 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "GTPase activation" "Deafness, Disease variant, Epilepsy, Mental retardation, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "salivary gland: 16.5" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 43.8;Inhibitory neurons: 34.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "SCLC-21H: 34.7" "HPA044712, HPA068080" Uncertain Supported "Plasma membrane,Cell Junctions" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 22: Non-specific - Unknown function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 30: Mammary glandular cells - Lactation" "Plasma membrane, Cell Junctions" "HPA044712: AB_10795619, HPA068080: AB_2685948" "prognostic unfavorable (3.22e-4)" "unprognostic (5.23e-2)" "unprognostic (4.02e-2)" "unprognostic (6.41e-2)" "unprognostic (3.52e-1)" "unprognostic (1.52e-2)" "unprognostic (1.40e-1)" "unprognostic (2.03e-2)" "unprognostic (1.68e-1)" "unprognostic (7.37e-2)" "unprognostic (4.37e-2)" "unprognostic (1.28e-1)" "unprognostic (4.66e-3)" "unprognostic (2.02e-2)" "unprognostic (8.19e-2)" "unprognostic (7.78e-3)" "unprognostic (1.61e-1)" 3.8 3.3 7.5 1.8 8.1 2.5 2.8 3.6 10.5 2.1 0.0 2.0 2.2 1.4 2.8 1.0 2.3 1.9 3.0 8.3 3.7 4.3 3.7 3.9 1.8 2.9 2.9 1.0 10.6 1.9 2.6 2.1 3.1 2.5 0.9 4.2 16.5 3.5 3.4 1.2 1.6 1.7 1.9 2.0 2.2 1.2 4.4 0.9 3.1 1.7 1.2 1.8 0.9 2.8 3.4 6.7 4.5 9.2 5.1 5.1 3.8 6.2 3.3 4.0 3.5 6.2 2.9 8.6 5.2 4.9 1.9 6.3 7.1 2.0 2.9 9.3 8.0 8.0 9.5 5.5 3.1 5.9 3.2 1.9 2.8 3.5 1.4 2.8 5.1 3.3 9.9 4.8 3.8 6.4 4.1 11.9 4.0 3.2 4.3 20.9 8.5 6.1 2.9 2.3 34.7 8.5 3.8 15.3 2.6 1.6 4.8 5.2 5.4 7.8 8.4 7.9 6.2 3.2 3.0 11.0 3.4 8.5 7.2 0.0 0.1 0.0 0.3 0.1 0.1 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.2 7.5 8.1 3.6 10.5 8.3 3.7 2.9 2.9 3.1 1.9 4.4 2.8 4.7 28.9 26.7 15.7 1.9 0.5 3.0 1.4 1.8 19.0 17.8 10.8 6.9 10.0 6.9 5.5 43.8 1.5 5.6 2.4 33.2 5.0 0.2 2.8 10.0 5.4 11.4 6.5 29.6 6.1 1.0 5.8 5.6 4.0 3.8 6.0 10.4 17.3 3.5 26.9 34.0 2.6 6.1 5.1 3.3 1.0 9.0 3.0 1.8 6.5 3.6 13.8 6.2 25.1 9.7 5.0 2.8 6.0 1.7 3.1 1.8 3.9 3.6 25.5 0.0 11.2 3.7 8.8 5.9 1.4 1.4 0.3 2.9 3.4 4.7 1.6 TBCD ENSG00000141556 "Tubulin folding cofactor D" Q9BTW9 17 82752065-82945914 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Chaperone, GTPase activation" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MOLT-4: 204.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045200 Approved NA NA 6200 "Cluster 7: Monocytes - Unknown function" "Cluster 46: Fibroblasts - ECM organization" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "HPA045200: AB_10969134" "unprognostic (4.15e-1)" "unprognostic (1.01e-2)" "unprognostic (1.53e-1)" "unprognostic (2.99e-3)" "unprognostic (2.72e-1)" "unprognostic (4.73e-2)" "prognostic unfavorable (2.39e-5)" "unprognostic (3.41e-3)" "unprognostic (9.03e-3)" "unprognostic (5.35e-2)" "unprognostic (1.75e-3)" "unprognostic (6.40e-2)" "unprognostic (1.16e-1)" "unprognostic (4.96e-1)" "unprognostic (1.10e-1)" "unprognostic (1.02e-1)" "unprognostic (1.53e-2)" 34.3 23.9 17.6 22.2 19.0 23.2 31.7 12.1 17.6 32.7 17.9 22.9 15.5 27.1 24.7 28.9 26.8 33.0 39.3 18.3 14.4 26.6 25.7 26.3 24.0 16.9 15.2 25.7 28.4 26.3 26.5 27.5 17.1 28.1 14.8 11.3 70.0 18.7 25.1 23.3 23.3 21.6 11.1 34.6 30.6 24.5 14.7 51.7 36.7 18.5 21.1 26.1 26.6 16.9 63.1 61.9 63.9 89.8 36.9 40.5 65.3 37.0 24.1 40.5 28.2 34.9 16.6 36.7 34.3 44.3 52.0 64.8 144.6 36.0 34.5 46.7 56.7 85.8 52.8 46.1 23.9 30.8 60.9 33.8 26.2 30.5 13.6 28.4 122.6 68.5 47.2 14.9 35.1 70.9 204.4 19.4 30.1 32.2 45.0 107.9 71.7 23.1 28.5 59.2 61.5 70.9 40.0 70.0 24.6 39.7 52.7 18.7 52.8 75.9 56.8 48.2 60.4 21.1 17.2 40.7 47.3 37.7 29.5 21.3 17.7 9.6 23.4 41.3 28.6 1.3 21.0 24.7 15.4 1.1 8.6 10.4 3.7 18.2 51.7 3.0 16.8 16.9 17.6 19.0 12.1 17.6 18.3 14.4 16.9 15.2 17.1 11.1 14.7 16.9 50.3 19.2 43.2 31.0 9.1 6.8 10.7 9.3 8.6 15.6 16.0 13.8 7.0 11.5 15.7 12.9 12.5 31.8 14.8 11.1 11.7 12.0 11.5 17.8 11.7 34.3 16.2 24.4 48.5 15.2 27.9 18.3 27.5 27.5 38.1 30.5 16.1 26.4 25.7 13.5 43.9 11.4 32.6 15.7 7.0 20.8 15.2 14.2 19.6 31.9 10.8 7.5 17.5 19.6 45.4 9.7 4.7 18.8 16.7 9.9 6.0 16.0 14.9 13.8 6.6 15.7 10.6 15.9 21.8 15.8 10.1 49.7 29.3 21.0 15.3 12.1 TBK1 NAK ENSG00000183735 "TANK binding kinase 1" Q9UHD2 12 64452090-64502114 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Antiviral defense, Host-virus interaction, Immunity, Innate immunity" "Kinase, Serine/threonine-protein kinase, Transferase" "Amyotrophic lateral sclerosis, Disease variant, Glaucoma, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045797, HPA060211" Uncertain Enhanced Nucleoplasm,Vesicles NA NA "Cluster 34: Basophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm Vesicles "HPA045797: AB_2679457, HPA060211: AB_2684222" "unprognostic (4.73e-2)" "unprognostic (8.46e-2)" "unprognostic (6.07e-3)" "unprognostic (1.90e-1)" "unprognostic (1.94e-1)" "unprognostic (1.28e-1)" "prognostic unfavorable (3.30e-4)" "unprognostic (1.26e-1)" "prognostic unfavorable (3.48e-4)" "unprognostic (1.69e-1)" "unprognostic (2.54e-2)" "unprognostic (1.24e-2)" "prognostic unfavorable (4.20e-6)" "unprognostic (4.35e-2)" "unprognostic (1.30e-1)" "unprognostic (1.26e-2)" "unprognostic (9.56e-3)" 11.6 15.3 6.0 10.1 6.1 16.9 11.4 5.6 6.9 10.6 5.3 10.5 15.1 11.0 6.7 11.3 9.5 10.1 9.4 5.8 5.6 11.8 17.4 12.9 14.6 6.5 6.9 9.6 7.5 11.6 9.8 13.7 6.1 10.6 8.5 6.3 10.2 9.0 18.4 8.6 11.4 10.8 5.3 13.4 10.2 23.5 6.7 6.8 8.5 14.9 12.9 16.0 10.2 7.1 23.3 24.2 11.1 10.6 24.7 26.1 29.0 22.9 37.6 22.5 21.1 14.9 12.4 31.5 21.4 26.8 34.4 19.0 19.4 20.0 26.4 29.5 17.1 33.0 15.3 19.1 30.2 35.2 36.4 18.5 19.1 23.1 23.6 42.3 32.4 11.0 27.9 38.7 31.6 27.0 0.9 17.0 29.9 22.9 13.8 14.9 15.3 31.8 25.1 36.9 9.8 14.7 33.3 36.0 23.5 23.5 33.1 24.9 25.9 20.2 18.1 14.9 24.0 25.4 54.3 30.3 28.1 18.6 26.1 41.8 10.1 24.3 13.9 17.7 16.3 12.8 10.1 15.2 12.2 10.1 2.8 8.7 17.8 26.6 15.5 2.1 13.6 10.0 6.0 6.1 5.6 6.9 5.8 5.6 6.5 6.9 6.1 5.3 6.7 7.1 23.7 19.2 20.5 28.4 21.6 11.0 25.7 20.1 15.4 17.0 14.9 9.1 10.9 8.6 23.4 22.0 10.4 28.8 30.0 14.1 11.7 19.3 34.5 19.2 17.9 28.6 17.3 18.3 50.5 23.6 32.6 21.3 15.3 30.2 43.1 17.5 16.8 17.1 20.2 18.5 42.2 10.5 12.2 23.0 30.2 29.2 19.3 31.1 14.2 46.9 31.4 12.7 33.0 39.2 52.3 16.9 10.9 20.7 25.6 43.7 13.6 12.3 20.8 16.3 26.3 22.4 18.7 68.9 12.7 14.0 14.9 92.6 27.1 11.5 10.1 41.6 TBL1Y TBL1 ENSG00000092377 "Transducin beta like 1 Y-linked" Q9BQ87 Y 6910686-7101970 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" Activator "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "prostate: 2.9;thyroid gland: 1.6" "Cell type enhanced" "Detected in some" "Basal squamous epithelial cells: 3.4;Inhibitory neurons: 2.2;Oligodendrocyte precursor cells: 1.0;Squamous epithelial cells: 5.7;Urothelial cells: 1.1" "Cancer enriched" "Detected in single" 6 "prostate cancer: 1.7" "Region enhanced" "Detected in single" "basal ganglia: 1.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "U-698: 12.3" "HPA050857, HPA060073" Uncertain Supported Nucleoplasm NA NA "Cluster 7: Kidney - Transmembrane transport" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA050857: , HPA060073: AB_2684196" "unprognostic (2.81e-3)" "unprognostic (2.94e-1)" "unprognostic (3.06e-1)" "unprognostic (7.76e-2)" "unprognostic (1.17e-2)" "unprognostic (1.28e-1)" "unprognostic (2.77e-2)" "unprognostic (1.47e-1)" "unprognostic (3.24e-2)" 0.3 0.0 0.1 0.0 1.3 0.0 0.3 0.1 0.4 0.0 0.4 0.1 0.0 0.0 0.1 0.3 0.0 0.4 0.0 0.1 0.4 0.9 0.6 0.1 0.0 0.2 0.2 0.0 0.4 0.0 0.0 0.1 0.1 2.9 0.1 0.0 0.8 0.3 0.4 0.2 0.0 0.0 0.3 0.0 0.2 0.3 0.1 0.0 1.6 0.1 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 1.6 0.0 0.0 0.0 0.0 1.9 0.0 2.2 1.7 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.3 0.1 0.4 0.1 0.4 0.2 0.2 0.1 0.3 0.1 0.2 0.0 0.0 0.0 0.7 0.0 0.0 0.8 0.2 3.4 0.0 0.0 0.0 0.5 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 2.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.1 0.1 0.0 0.0 0.0 0.5 0.0 0.4 0.1 0.0 0.0 0.0 0.1 0.0 0.2 5.7 0.0 0.3 0.0 0.0 0.0 1.1 TBP "GTF2D1, SCA17, TFIID" ENSG00000112592 "TATA-box binding protein" P20226 6 170554302-170572870 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Host-virus interaction, Transcription, Transcription regulation" DNA-binding "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Spermatocytes: 88.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009442, HPA049805" Enhanced Supported Nucleoplasm NA NA "Cluster 6: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 1: K-562 - Erythropoiesis" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm "CAB009442: AB_632480, HPA049805: AB_2680890" "unprognostic (2.86e-3)" "unprognostic (1.73e-2)" "unprognostic (3.90e-2)" "unprognostic (4.55e-3)" "unprognostic (7.10e-2)" "unprognostic (2.33e-2)" "prognostic unfavorable (1.51e-7)" "unprognostic (1.46e-1)" "unprognostic (4.28e-1)" "unprognostic (1.17e-2)" "unprognostic (1.06e-2)" "unprognostic (1.34e-2)" "unprognostic (1.54e-2)" "unprognostic (8.13e-2)" "unprognostic (2.62e-1)" "unprognostic (3.70e-2)" "unprognostic (3.05e-1)" 10.2 10.5 9.4 9.6 9.6 15.6 10.4 10.8 15.1 10.5 9.1 11.8 8.5 12.6 8.1 11.3 11.7 8.2 9.9 10.1 11.5 11.0 11.5 9.7 14.0 10.2 10.2 12.8 11.7 9.3 9.3 10.8 10.2 10.5 8.5 8.9 10.3 7.6 12.8 10.7 11.9 9.6 8.7 14.9 11.7 34.5 9.7 11.9 10.5 10.6 12.2 10.6 10.8 12.3 12.9 14.0 24.4 31.2 12.5 14.2 23.0 20.5 15.6 19.9 21.1 28.9 12.7 27.1 16.4 16.7 28.6 18.9 31.6 16.8 21.2 31.5 23.2 27.6 16.6 26.1 18.1 32.7 23.1 13.8 19.2 22.9 25.8 16.3 15.9 37.2 49.7 16.5 18.3 19.3 32.8 31.8 24.5 27.3 11.0 28.6 20.0 23.8 14.5 6.5 10.4 24.9 24.1 17.8 16.0 20.7 12.4 40.7 17.6 13.5 19.1 22.2 32.0 24.4 35.1 42.3 18.5 27.0 21.9 67.4 30.8 39.8 37.8 32.2 44.4 52.9 36.7 38.6 30.2 49.9 47.3 40.0 44.4 35.0 45.4 42.6 37.2 21.8 9.4 9.6 10.8 15.1 10.1 11.5 10.2 10.2 10.2 8.7 9.7 12.3 8.4 9.6 6.9 6.8 16.5 5.5 5.3 11.6 20.5 7.5 8.3 7.4 9.9 15.7 10.0 12.9 8.4 15.8 10.5 6.2 3.9 6.6 26.9 7.8 9.3 9.5 7.2 17.5 13.7 4.7 13.5 9.2 7.7 10.7 1.3 13.0 13.2 8.0 10.1 0.0 12.8 7.5 22.4 14.0 5.3 7.7 10.8 9.8 1.8 10.3 8.5 5.4 6.2 11.1 16.2 6.6 7.9 10.5 18.7 8.5 8.2 8.9 7.2 6.7 13.1 6.6 11.1 88.1 17.4 18.3 6.7 13.5 11.1 10.1 8.0 6.7 TCF4 "bHLHb19, E2-2, ITF2, SEF2-1B" ENSG00000196628 "Transcription factor 4" P15884 18 55222185-55664787 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Differentiation, Neurogenesis, Transcription, Transcription regulation" "Activator, DNA-binding" "Corneal dystrophy, Disease variant, Epilepsy, Mental retardation, Primary microcephaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 65.1" "Cell type enhanced" "Detected in many" "Adipocytes: 820.0;Endothelial cells: 574.5;Inhibitory neurons: 1177.6;Oligodendrocyte precursor cells: 719.8;Oligodendrocytes: 573.6" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "cerebellum: 65.1" "Group enriched" "Detected in many" 14 "memory B-cell: 173.6;naive B-cell: 146.8;plasmacytoid DC: 559.8" "Group enriched" "Detected in many" 33 "B-cells: 173.6;dendritic cells: 559.8" "Cell line enhanced" "Detected in many" "HDLM-2: 140.4;SH-SY5Y: 157.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB020722, HPA025958" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Nucleoplasm, Cytosol" "CAB020722: , HPA025958: AB_1857849" "unprognostic (2.11e-1)" "unprognostic (9.10e-2)" "unprognostic (8.69e-2)" "unprognostic (7.89e-3)" "unprognostic (1.42e-1)" "unprognostic (1.36e-3)" "unprognostic (3.03e-2)" "unprognostic (8.64e-2)" "unprognostic (1.79e-2)" "unprognostic (3.29e-2)" "unprognostic (2.77e-1)" "unprognostic (8.44e-2)" "prognostic unfavorable (7.24e-5)" "unprognostic (1.99e-3)" "unprognostic (2.68e-2)" "unprognostic (2.76e-3)" "prognostic unfavorable (9.95e-4)" 20.3 9.6 3.7 12.8 12.5 9.5 11.6 65.1 26.5 28.5 0.0 7.4 5.1 23.0 2.1 9.7 13.4 17.4 17.5 29.8 0.0 4.4 4.4 15.5 14.7 5.5 1.0 25.9 5.8 8.0 6.5 28.9 3.9 6.6 7.9 14.0 6.8 10.2 6.1 6.4 5.0 24.1 2.2 13.1 6.0 15.4 2.4 9.8 13.3 16.7 14.7 13.1 7.3 14.4 0.1 4.1 36.8 11.4 8.5 14.4 0.1 18.4 40.6 13.2 17.2 23.1 3.6 28.8 0.1 41.9 2.7 4.5 17.9 17.1 9.2 140.4 13.9 12.1 0.1 0.0 4.0 5.3 2.8 19.6 5.3 18.5 0.7 9.1 45.8 1.6 19.5 22.0 11.0 0.0 7.6 0.0 10.4 0.1 2.4 41.6 14.9 65.4 0.0 0.9 12.6 157.7 0.0 1.5 0.0 11.1 1.6 1.3 49.1 48.5 17.4 2.1 14.6 16.3 32.2 25.7 11.0 5.2 15.5 0.9 7.4 0.8 0.9 8.3 0.7 173.6 0.2 0.5 20.6 146.8 0.5 0.3 1.8 11.2 7.4 559.8 0.7 11.3 3.7 12.5 65.1 26.5 29.8 0.0 5.5 1.0 3.9 2.2 2.4 14.4 820.0 6.4 13.1 501.1 217.4 117.0 37.8 34.0 80.8 293.0 6.5 23.4 35.5 4.3 32.6 22.0 83.4 1.8 446.8 0.1 0.0 1.5 103.2 17.5 201.4 574.5 5.4 34.2 503.8 7.1 1.5 296.7 1.5 12.2 13.9 105.7 316.3 6.6 39.6 25.2 1177.6 0.3 26.4 112.4 129.2 116.3 205.3 80.4 64.0 474.1 32.7 372.8 13.4 719.8 573.6 2.1 0.1 182.1 131.7 20.8 0.0 2.3 25.9 54.7 236.7 304.5 221.0 8.7 14.5 47.5 84.4 2.6 15.1 164.8 0.2 17.8 TDP1 "FLJ11090, SCAN1" ENSG00000042088 "Tyrosyl-DNA phosphodiesterase 1" Q9NUW8 14 89954939-90044764 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "DNA damage, DNA repair" "Exonuclease, Hydrolase, Nuclease" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 123.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA071317 Approved Supported "Nucleoplasm,Plasma membrane" No No "Cluster 44: Non-specific - Transcription" "Cluster 3: T-cells - Adaptive immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 23: Spermatids - Flagellum & Golgi organization" Nucleoplasm "Plasma membrane" "HPA071317: AB_2686388" "unprognostic (5.60e-3)" "unprognostic (3.53e-1)" "unprognostic (7.03e-3)" "unprognostic (1.34e-1)" "unprognostic (7.45e-2)" "unprognostic (7.22e-2)" "prognostic unfavorable (8.99e-5)" "unprognostic (2.61e-1)" "unprognostic (1.46e-2)" "unprognostic (5.84e-3)" "unprognostic (2.51e-1)" "unprognostic (6.46e-2)" "unprognostic (1.10e-1)" "unprognostic (3.41e-1)" "unprognostic (1.64e-1)" "unprognostic (2.91e-2)" "unprognostic (1.26e-1)" 5.5 3.9 4.8 11.8 4.5 13.9 8.9 6.6 4.9 6.6 7.1 7.8 6.5 5.9 5.8 8.2 9.2 6.6 2.6 4.1 5.3 7.0 6.5 4.7 19.0 3.8 3.6 6.4 4.8 5.1 4.6 8.2 3.9 5.0 10.1 4.9 5.5 4.3 2.1 6.4 7.0 6.3 2.8 10.6 7.9 22.3 4.6 28.3 4.9 1.7 23.7 8.1 5.0 4.2 33.8 18.6 40.9 37.5 10.1 14.0 32.7 31.7 25.9 38.4 34.6 13.6 35.5 42.9 23.3 21.7 12.9 33.9 18.2 29.5 55.2 44.1 19.6 43.9 16.7 16.6 8.7 73.2 24.1 10.1 12.9 26.9 24.9 21.9 49.5 57.3 30.6 43.5 45.9 35.0 56.3 39.2 10.0 39.8 43.7 42.3 77.3 34.0 24.6 27.3 30.7 20.9 26.9 77.6 10.1 27.0 31.0 30.8 39.9 16.5 15.7 23.0 28.7 31.8 60.4 52.3 35.5 32.3 24.6 28.7 8.9 15.1 18.8 14.6 18.3 21.1 19.8 20.8 14.2 20.0 21.7 23.1 5.7 23.8 14.1 15.0 32.2 14.8 4.8 4.5 6.6 4.9 4.1 5.3 3.8 3.6 3.9 2.8 4.6 4.2 2.9 0.0 1.1 4.2 15.2 4.7 4.9 7.4 4.0 3.0 6.4 7.1 1.4 1.5 5.0 14.7 8.4 11.4 14.6 3.8 5.9 9.2 123.5 13.2 6.1 3.6 3.6 12.8 13.4 5.6 14.9 4.3 7.7 9.2 2.5 8.9 3.9 4.2 8.8 3.3 13.9 4.9 0.0 6.8 10.2 36.7 2.8 7.8 1.8 1.9 8.0 1.5 8.2 8.0 24.2 6.4 4.8 3.0 16.9 5.7 2.9 7.8 11.0 2.7 0.0 3.4 5.4 33.7 22.8 8.7 4.5 10.1 15.0 10.3 7.9 4.0 TDP2 TTRAP ENSG00000111802 "Tyrosyl-DNA phosphodiesterase 2" O95551 6 24649979-24666930 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "DNA damage, DNA repair, Host-virus interaction" "Hydrolase, Nuclease" "Mental retardation, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 183.2" "Cell type enhanced" "Detected in all" "Distal enterocytes: 530.9;Paneth cells: 428.1;Proximal enterocytes: 637.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "basophil: 75.6;neutrophil: 228.9" "Lineage enriched" "Detected in all" 7 "granulocytes: 228.9" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB073398, HPA074011" Enhanced Supported "Nucleoplasm,Nuclear bodies" "Intracellular and membrane" No No "Cluster 9: Neutrophils - Innate immune response" "Cluster 9: Intestine - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 45: Enterocytes - Digestion" "Nucleoplasm, Nuclear bodies" "CAB073398: , HPA074011: AB_2686651" "unprognostic (2.46e-2)" "unprognostic (2.10e-3)" "unprognostic (1.83e-1)" "unprognostic (2.19e-2)" "unprognostic (2.58e-1)" "unprognostic (4.66e-3)" "unprognostic (4.13e-3)" "unprognostic (3.24e-1)" "unprognostic (5.78e-3)" "prognostic favorable (2.53e-7)" "unprognostic (1.20e-2)" "prognostic unfavorable (1.86e-4)" "unprognostic (1.40e-2)" "unprognostic (1.42e-1)" "unprognostic (9.70e-3)" "unprognostic (1.14e-1)" "prognostic favorable (1.47e-5)" 24.4 23.7 27.4 34.3 28.4 21.8 27.3 30.4 36.4 20.6 30.4 141.6 120.1 19.7 25.3 18.6 22.6 28.6 28.2 28.0 28.9 77.9 51.2 24.5 38.9 28.2 29.5 21.3 29.5 25.7 20.3 20.1 28.7 56.5 127.4 18.9 21.9 21.7 21.9 21.1 183.2 24.6 28.3 27.9 26.2 25.3 32.1 37.5 21.7 26.3 37.7 27.2 16.5 28.3 47.7 37.1 41.5 48.1 63.0 64.0 32.4 41.4 53.1 38.9 51.9 50.8 26.3 57.0 70.1 43.8 90.0 34.2 51.2 47.3 52.9 73.6 53.1 53.4 37.7 84.2 40.1 82.8 49.5 43.1 43.7 40.7 36.5 46.0 63.9 54.1 48.8 23.7 59.2 34.1 64.7 52.8 37.1 54.7 31.8 55.5 43.7 61.6 67.0 66.5 52.2 29.8 33.6 84.5 71.0 42.2 38.9 47.4 48.0 37.6 31.3 28.3 61.4 33.7 107.9 77.1 26.0 107.5 61.3 75.6 13.9 29.4 25.0 14.8 30.8 20.0 28.8 27.9 13.2 14.5 24.0 26.2 228.9 29.0 16.5 12.4 31.9 22.7 27.4 28.4 30.4 36.4 28.0 28.9 28.2 29.5 28.7 28.3 32.1 28.3 24.0 6.4 16.7 23.5 24.1 14.1 25.1 37.0 18.8 12.7 19.8 20.2 23.4 37.1 29.6 22.0 6.2 18.4 23.0 530.9 49.0 35.4 140.6 19.4 16.6 22.5 52.7 20.8 25.9 36.0 23.6 18.3 14.3 19.7 24.1 15.7 27.5 31.4 68.4 6.7 25.8 168.9 30.5 28.9 20.0 80.2 18.0 33.5 12.4 15.0 61.7 19.5 38.1 11.6 21.2 21.4 428.1 23.3 10.7 37.0 637.5 175.8 30.5 15.8 32.9 19.1 20.4 9.0 32.7 10.4 16.6 44.3 28.5 15.7 119.3 31.9 TDRD7 PCTAIRE2BP ENSG00000196116 "Tudor domain containing 7" Q8NHU6 9 97412096-97496125 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Differentiation, Spermatogenesis" RNA-binding "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "retina: 63.1" "Cell type enhanced" "Detected in many" "Early spermatids: 44.7;Microglial cells: 33.7;Rod photoreceptor cells: 44.4;Spermatocytes: 36.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "GAMG: 56.5;HDLM-2: 55.6;THP-1: 54.4" "Low region specificity" "Detected in all" "CAB020800, HPA022250, HPA024529" Enhanced Supported "Nucleoplasm,Cytoplasmic bodies" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 77: Retina - Visual perception" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 46: Photoreceptor cells - Phototransduction" "Cytoplasmic bodies" Nucleoplasm "CAB020800: , HPA022250: , HPA024529: AB_1857869" "unprognostic (8.22e-2)" "unprognostic (1.62e-2)" "unprognostic (3.28e-3)" "unprognostic (1.03e-1)" "unprognostic (2.88e-1)" "unprognostic (3.07e-1)" "prognostic unfavorable (5.91e-4)" "unprognostic (2.88e-2)" "unprognostic (9.86e-2)" "unprognostic (2.00e-1)" "unprognostic (1.06e-1)" "unprognostic (2.74e-2)" "prognostic favorable (4.76e-5)" "unprognostic (4.03e-2)" "unprognostic (2.90e-1)" "unprognostic (1.17e-2)" "unprognostic (2.67e-1)" 7.3 6.2 11.9 8.0 13.6 11.1 6.7 13.0 12.5 6.7 10.4 14.4 15.8 6.9 6.4 8.9 8.8 10.2 6.5 11.0 13.1 6.9 8.1 9.7 8.1 14.2 12.3 7.4 5.7 9.8 5.9 8.9 14.4 6.1 13.9 63.1 7.5 7.3 4.7 5.4 13.7 9.8 14.6 9.0 8.5 36.9 12.3 11.0 7.9 5.4 8.4 8.2 6.7 15.4 17.1 11.7 0.0 4.0 8.7 11.2 9.8 10.6 26.7 35.8 39.9 15.2 14.1 1.1 5.1 15.1 56.5 12.8 9.8 5.4 9.6 55.6 8.3 7.8 5.5 11.1 7.9 17.6 18.0 3.8 10.7 11.9 1.2 10.7 15.7 8.2 4.4 0.8 9.5 10.2 8.8 8.6 1.7 20.1 6.2 3.8 5.9 0.2 8.8 11.4 1.8 4.8 14.8 6.5 41.6 6.2 3.9 54.4 16.1 4.5 4.4 11.4 8.2 5.5 6.9 1.0 10.6 9.4 11.8 1.7 2.2 7.2 1.1 4.3 1.6 3.0 1.5 1.1 3.2 2.5 1.2 1.9 4.2 1.2 4.2 0.7 1.1 1.2 11.9 13.6 13.0 12.5 11.0 13.1 14.2 12.3 14.4 14.6 12.3 15.4 7.0 0.0 3.0 10.4 5.7 1.7 2.6 2.2 2.8 8.2 2.7 2.4 6.4 1.5 4.0 3.7 18.8 1.7 3.0 14.2 5.9 4.4 44.7 11.1 5.2 6.0 6.0 1.7 18.5 4.9 2.2 4.3 10.2 8.0 0.0 5.4 2.9 2.5 4.8 5.0 19.0 7.9 2.0 6.4 1.8 23.9 4.4 7.3 1.8 33.7 10.8 8.6 1.0 21.1 29.9 6.1 7.6 3.8 4.3 2.2 8.9 2.8 12.9 44.4 6.6 3.7 4.2 36.4 15.7 4.4 2.3 0.7 4.7 2.6 7.2 4.3 TEAD1 "AA, TCF13, TEF-1" ENSG00000187079 "TEA domain transcription factor 1" P28347 11 12674421-12944737 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 230.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA057339, HPA062471" Enhanced Nucleoplasm NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 44: Endometrium - Transcription" Nucleoplasm "HPA057339: AB_2683413, HPA062471: AB_2684773" "unprognostic (1.00e-1)" "unprognostic (2.53e-2)" "unprognostic (8.84e-2)" "unprognostic (9.93e-3)" "unprognostic (2.05e-2)" "unprognostic (4.50e-1)" "unprognostic (1.50e-1)" "unprognostic (1.75e-1)" "unprognostic (1.43e-1)" "unprognostic (4.40e-3)" "unprognostic (8.39e-2)" "unprognostic (4.76e-2)" "unprognostic (1.41e-2)" "unprognostic (7.08e-3)" "unprognostic (2.52e-1)" "unprognostic (3.14e-1)" "unprognostic (2.18e-2)" 29.5 12.1 11.1 8.2 11.6 0.0 17.8 8.6 8.5 23.4 30.6 36.1 7.7 26.4 7.1 29.8 19.2 18.5 31.3 14.5 14.8 17.2 13.6 15.9 4.2 15.1 12.3 21.9 15.2 27.1 14.4 33.3 10.5 18.8 13.0 10.5 10.2 20.1 67.5 13.2 11.9 27.2 13.3 7.3 16.4 8.6 15.6 4.2 17.8 72.6 5.6 33.9 14.7 12.9 62.8 52.1 43.9 58.7 59.9 62.1 65.4 89.2 76.2 71.6 69.7 53.8 54.5 0.4 23.0 120.9 32.3 37.0 53.7 35.9 115.5 0.2 17.6 0.0 107.3 18.1 55.8 0.0 4.7 51.8 18.3 50.4 68.2 58.6 15.2 3.9 26.0 0.2 111.2 13.1 0.1 0.6 17.2 14.5 23.5 0.3 64.8 33.2 48.2 37.2 26.9 31.2 90.9 43.1 59.0 63.8 20.0 4.4 32.0 107.8 76.2 84.9 59.5 8.6 17.3 12.0 41.6 0.2 69.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.1 11.6 8.6 8.5 14.5 14.8 15.1 12.3 10.5 13.3 15.6 12.9 37.9 89.8 21.7 230.8 0.4 99.3 32.2 19.3 39.9 12.9 16.4 20.2 75.0 31.5 33.1 49.7 12.5 24.1 0.2 11.0 1.9 16.6 6.5 80.8 97.4 33.3 46.7 0.0 101.8 12.8 52.4 46.5 18.8 142.9 0.0 57.7 25.7 39.8 3.7 1.7 108.4 13.5 10.2 1.9 16.0 7.2 23.6 1.9 24.9 91.8 0.0 31.2 0.0 121.2 69.7 34.8 8.1 24.0 1.4 69.4 6.7 29.8 53.8 17.5 6.6 73.5 46.7 3.0 22.3 29.9 54.8 12.3 2.0 45.5 10.4 54.6 TECPR2 KIAA0329 ENSG00000196663 "Tectonin beta-propeller repeat containing 2" O15040 14 102362941-102502477 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Autophagy "Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 57.5;Excitatory neurons: 59.1;Oligodendrocytes: 150.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 8 "neutrophil: 7.3" "Lineage enriched" "Detected in single" 13 "granulocytes: 7.3" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" HPA000658 Enhanced Approved Nucleoplasm,Nucleoli,Centrosome NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 21: Non-specific - Transcription" "Cluster 18: U-2197 - ECM organization" "Cluster 51: Myeloid cells - Hemostasis" Nucleoplasm "Nucleoli, Centrosome" "HPA000658: AB_1079191" "unprognostic (6.81e-2)" "unprognostic (1.21e-1)" "unprognostic (3.77e-2)" "unprognostic (2.62e-1)" "unprognostic (4.46e-1)" "unprognostic (1.63e-3)" "prognostic unfavorable (5.66e-5)" "unprognostic (1.17e-1)" "unprognostic (3.22e-2)" "unprognostic (1.64e-1)" "unprognostic (5.76e-3)" "unprognostic (3.78e-2)" "prognostic favorable (6.53e-9)" "unprognostic (1.39e-2)" "unprognostic (1.48e-1)" "unprognostic (1.91e-1)" "unprognostic (1.56e-3)" 5.4 5.1 12.4 5.4 18.8 5.7 5.4 12.1 13.9 6.0 5.6 8.3 3.8 7.9 6.7 4.9 6.4 4.5 7.5 12.9 10.5 4.4 4.1 5.1 2.7 13.0 14.7 5.9 4.5 9.0 7.2 5.7 12.2 6.4 3.2 9.7 10.1 7.2 11.1 5.6 4.7 8.7 10.4 5.7 5.4 10.9 15.4 5.5 5.7 7.8 2.9 7.2 5.0 21.5 4.7 9.4 8.9 7.4 18.0 13.6 4.9 10.4 12.0 10.3 8.6 2.0 3.4 3.5 6.4 10.9 7.6 8.4 6.2 7.8 8.6 13.0 4.1 4.2 4.9 4.1 8.5 2.3 3.9 9.0 6.8 9.3 6.1 9.7 10.2 3.9 2.1 7.8 9.6 8.9 2.1 2.5 3.4 4.9 9.7 5.0 6.2 1.1 5.2 7.8 7.1 6.6 9.0 2.3 5.7 5.7 10.5 3.1 10.6 7.9 2.0 21.4 4.4 8.0 5.1 0.7 7.6 6.1 8.3 0.3 0.5 0.9 0.2 0.3 0.2 0.0 0.2 0.1 0.2 0.1 0.3 0.1 7.3 0.1 0.1 0.1 0.4 0.4 12.4 18.8 12.1 13.9 12.9 10.5 13.0 14.7 12.2 10.4 15.4 21.5 9.1 9.6 6.9 57.5 3.5 2.0 3.1 4.7 8.0 17.0 10.1 8.0 13.0 4.3 5.6 3.7 50.1 7.1 5.7 7.2 5.9 8.2 31.2 7.4 10.3 8.7 4.2 5.7 59.1 7.1 5.7 8.4 5.6 6.3 0.0 8.6 8.2 6.1 4.9 13.5 34.4 3.8 10.2 4.7 3.4 27.9 14.3 12.7 3.6 26.2 8.5 21.6 5.2 28.6 150.4 6.8 2.5 18.8 8.0 4.0 5.9 6.0 7.0 44.7 19.7 9.1 8.3 24.6 15.0 7.7 1.6 6.0 4.6 8.4 4.6 3.2 TECTA "DFNA12, DFNA8, DFNB21" ENSG00000109927 "Tectorin alpha" O75443 11 121101243-121191490 "Disease related genes, Human disease related genes, Predicted membrane proteins, Predicted secreted proteins" Hearing "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in some" "Cell type enhanced" "Detected in some" "Astrocytes: 5.2;Cone photoreceptor cells: 4.2;Early spermatids: 5.6;Excitatory neurons: 9.9;Hepatic stellate cells: 8.9;Inhibitory neurons: 7.2;Oligodendrocyte precursor cells: 5.0" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 1.1;SH-SY5Y: 1.7" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA018870 Approved "Secreted in other tissues" NA NA "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA018870: AB_1857879" "unprognostic (1.12e-3)" "unprognostic (2.42e-1)" "unprognostic (1.42e-2)" "unprognostic (1.45e-2)" "unprognostic (4.30e-2)" "unprognostic (3.11e-1)" "unprognostic (3.00e-2)" "unprognostic (3.34e-2)" "unprognostic (1.63e-1)" "unprognostic (1.14e-1)" "unprognostic (1.39e-6)" "unprognostic (1.22e-1)" "unprognostic (4.15e-3)" "unprognostic (6.97e-3)" "unprognostic (1.12e-1)" "unprognostic (3.28e-2)" "unprognostic (4.19e-2)" 0.3 0.5 1.6 0.2 2.1 0.2 0.3 1.0 1.6 0.3 1.5 0.5 0.1 0.3 0.6 0.1 0.3 0.3 1.1 1.3 2.0 0.5 0.4 0.4 0.1 1.5 1.4 0.7 0.3 0.8 1.3 0.2 1.5 0.5 0.1 1.1 0.3 0.5 0.8 0.1 0.2 0.2 0.9 0.3 0.3 0.9 1.6 0.2 0.7 0.4 0.1 0.3 0.2 1.9 0.0 0.0 1.1 0.5 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.3 0.1 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.0 0.0 0.1 0.1 0.2 0.0 0.3 0.1 0.0 0.0 0.4 0.2 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.7 1.7 0.1 0.0 0.1 0.7 0.0 0.1 0.0 0.1 0.1 0.0 0.1 0.4 0.4 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 2.1 1.0 1.6 1.3 2.0 1.5 1.4 1.5 0.9 1.6 1.9 0.5 3.2 0.5 5.2 0.1 0.0 0.1 0.0 0.0 1.8 0.2 0.3 1.9 1.5 0.6 0.0 4.2 0.0 0.2 0.0 0.0 0.2 5.6 0.6 0.3 0.5 0.0 0.0 9.9 0.4 0.1 0.4 0.0 0.3 0.0 0.6 8.9 0.6 0.1 0.0 7.2 0.0 0.0 0.3 0.0 2.7 0.3 0.2 0.0 1.0 0.2 0.9 0.0 5.0 2.8 0.0 0.0 0.4 0.1 0.0 0.0 0.2 0.2 0.7 0.0 1.9 0.4 0.9 0.3 0.1 0.0 0.0 0.1 0.1 0.0 0.0 TENM4 "KIAA1302, ODZ4, Ten-M4, TEN4" ENSG00000149256 "Teneurin transmembrane protein 4" Q6N022 11 78652829-79441030 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" Differentiation "Developmental protein" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 17.8;ovary: 16.6;parathyroid gland: 14.0" "Cell type enhanced" "Detected in many" "Astrocytes: 134.5;Early spermatids: 96.8;Excitatory neurons: 337.4;Inhibitory neurons: 297.7;Microglial cells: 117.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HSkMC: 9.1;hTERT-RPE1: 9.5;PC-3: 10.8;REH: 10.4;SH-SY5Y: 17.4" "Low region specificity" "Detected in all" "HPA019521, HPA065961" Approved NA NA "Cluster 57: Non-specific - Angiogenesis" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA019521: AB_2670171, HPA065961: AB_2685588" "unprognostic (2.81e-1)" "unprognostic (9.25e-2)" "unprognostic (1.64e-1)" "unprognostic (2.96e-3)" "unprognostic (1.87e-1)" "unprognostic (2.48e-1)" "unprognostic (1.18e-2)" "unprognostic (1.24e-1)" "unprognostic (3.01e-1)" "unprognostic (3.79e-1)" "unprognostic (1.01e-1)" "unprognostic (4.71e-1)" "unprognostic (6.51e-3)" "unprognostic (5.40e-3)" "unprognostic (5.64e-2)" "unprognostic (7.07e-2)" "unprognostic (9.81e-3)" 1.9 1.4 7.5 1.0 13.4 0.0 0.7 0.3 12.6 2.5 0.0 0.5 0.1 1.3 0.2 2.0 2.1 0.4 0.4 9.0 7.5 1.5 0.0 0.4 0.5 10.9 9.2 16.6 0.3 14.0 7.1 0.1 7.9 0.4 0.3 2.6 0.5 0.2 0.4 3.3 0.3 1.0 13.0 0.3 0.5 1.6 11.8 1.9 5.8 1.0 1.2 0.5 1.5 17.8 0.0 0.0 3.4 0.0 3.7 5.9 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 7.8 6.7 0.0 2.1 5.0 5.3 0.0 4.5 0.9 0.0 0.0 0.0 0.1 0.0 0.0 9.1 2.3 2.5 4.5 9.5 0.0 0.0 0.1 0.3 0.2 0.0 0.1 0.0 1.8 0.3 10.8 10.4 0.0 0.0 6.4 1.1 7.1 17.4 0.0 0.0 0.0 6.2 0.0 0.1 0.5 0.1 1.2 0.1 5.9 0.0 0.0 0.1 6.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.5 13.4 0.3 12.6 9.0 7.5 10.9 9.2 7.9 13.0 11.8 17.8 0.1 0.0 0.0 134.5 0.2 0.9 0.8 3.4 17.1 7.5 0.1 0.0 1.9 4.3 1.1 0.0 0.0 0.1 0.0 0.0 0.0 0.4 96.8 1.1 1.7 0.3 0.0 0.0 337.4 0.0 0.2 2.6 0.0 0.8 1.3 0.8 0.0 0.0 0.1 0.0 297.7 0.0 0.0 0.6 0.4 56.6 5.3 0.7 0.0 117.1 0.4 13.9 0.0 58.3 21.3 0.0 0.0 1.9 0.0 0.4 0.0 0.4 7.0 1.0 0.0 25.1 2.8 4.8 1.0 7.3 2.0 0.1 0.1 0.3 0.0 0.6 TFG "FLJ36137, SPG57, TF6" ENSG00000114354 "Trafficking from ER to golgi regulator" Q92734 3 100709295-100748964 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "ER-Golgi transport, Transport" "Cancer-related genes, Disease variant, Hereditary spastic paraplegia, Neurodegeneration, Neuropathy, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019473, HPA052206" Approved Supported Vesicles,Cytosol No No 320000 "Cluster 38: Basophils - Unknown function" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 30: Epithelial cell lines - Translation" "Cluster 55: Plasma cells - Humoral immune response" Vesicles Cytosol "HPA019473: AB_1857936, HPA052206: AB_2681760" "unprognostic (1.14e-1)" "unprognostic (3.58e-2)" "unprognostic (1.46e-1)" "unprognostic (2.94e-2)" "unprognostic (1.46e-1)" "unprognostic (4.14e-2)" "prognostic unfavorable (5.48e-4)" "unprognostic (3.31e-3)" "unprognostic (1.42e-1)" "unprognostic (3.73e-2)" "prognostic unfavorable (1.50e-4)" "unprognostic (4.58e-3)" "unprognostic (3.72e-2)" "unprognostic (2.82e-1)" "unprognostic (8.55e-2)" "unprognostic (3.33e-1)" "unprognostic (8.45e-2)" 62.2 73.0 40.7 37.2 40.4 37.4 52.4 43.5 46.4 53.9 46.7 63.8 89.8 52.0 78.5 85.7 51.2 56.4 82.6 41.3 45.4 71.9 113.9 55.6 29.4 44.2 43.2 48.2 66.7 89.0 64.1 79.2 44.4 47.9 69.6 40.9 60.6 61.3 75.5 58.9 76.6 66.5 43.2 42.6 54.4 47.7 42.3 40.6 64.1 58.2 54.9 61.6 57.3 44.4 203.8 107.5 126.7 79.0 160.1 176.4 163.9 141.1 190.4 182.5 213.0 136.0 96.1 24.7 103.3 180.4 141.3 143.1 143.4 161.5 216.2 123.8 87.4 99.7 69.3 130.0 183.3 70.2 51.8 149.3 216.6 108.4 190.8 165.1 165.5 44.5 73.1 63.5 191.9 143.9 63.3 56.7 122.5 193.8 169.3 55.5 77.8 89.0 226.5 125.9 96.4 93.1 95.0 118.2 175.8 103.4 141.7 103.1 113.1 103.0 130.8 48.4 104.4 56.2 65.8 92.1 171.2 79.7 130.7 84.3 43.6 42.8 30.8 45.2 37.4 37.4 31.6 34.5 43.1 35.9 29.4 29.7 26.1 43.1 44.8 29.3 41.0 37.0 40.7 40.4 43.5 46.4 41.3 45.4 44.2 43.2 44.4 43.2 42.3 44.4 67.9 60.9 36.9 46.4 43.3 136.6 105.9 183.6 69.4 46.8 58.0 50.2 83.5 48.6 93.1 36.8 25.0 211.6 43.1 111.8 137.0 190.3 101.5 70.8 70.4 70.2 52.6 27.1 54.8 107.7 201.5 97.8 47.4 79.0 76.8 62.9 53.9 68.4 86.2 57.2 59.2 128.5 122.1 27.3 84.9 45.5 70.8 43.6 64.0 38.4 98.5 88.0 28.8 49.3 55.0 130.5 91.0 74.1 75.8 133.5 202.5 106.4 63.9 60.3 39.5 81.3 87.2 79.2 51.5 68.0 118.9 284.4 43.2 90.0 97.2 123.0 TGFBI "BIGH3, CDB1, CDGG1, CSD1, CSD2, CSD3, LCD1" ENSG00000120708 "Transforming growth factor beta induced" Q15582 5 136028988-136063818 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Cell adhesion, Sensory transduction, Vision" "Amyloidosis, Corneal dystrophy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "placenta: 457.6" "Cell type enhanced" "Detected in many" "Hofbauer cells: 251.8;Kupffer cells: 292.9;Langerhans cells: 251.2;Macrophages: 198.9;Pancreatic endocrine cells: 590.1;Smooth muscle cells: 326.1" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in all" "thalamus: 77.3" "Group enriched" "Detected in many" 32 "classical monocyte: 252.3;intermediate monocyte: 149.1;myeloid DC: 156.9;non-classical monocyte: 121.4;plasmacytoid DC: 324.5" "Group enriched" "Detected in all" 46 "dendritic cells: 324.5;monocytes: 252.3" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 2857.3;GAMG: 2417.8;HSkMC: 2675.6;hTCEpi: 1915.6;LHCN-M2: 2269.4;U-2197: 1916.3;U-87 MG: 3667.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA008612, HPA017019" Enhanced "Secreted to blood" NA NA 1600000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 28: Placenta - Pregnancy" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 33: Fibroblasts - ECM organization" "HPA008612: AB_1857970, HPA017019: AB_2669511" "unprognostic (1.05e-1)" "prognostic unfavorable (1.03e-5)" "unprognostic (4.38e-3)" "prognostic favorable (1.17e-4)" "unprognostic (5.21e-3)" "unprognostic (5.53e-3)" "unprognostic (4.60e-2)" "unprognostic (8.71e-3)" "unprognostic (5.45e-2)" "prognostic unfavorable (1.14e-5)" "unprognostic (1.42e-3)" "unprognostic (2.26e-1)" "prognostic unfavorable (7.82e-10)" "unprognostic (8.81e-3)" "unprognostic (1.73e-2)" "unprognostic (3.42e-1)" "unprognostic (1.70e-3)" 133.2 55.3 9.5 164.0 10.4 25.9 112.2 10.0 25.5 51.8 51.9 92.8 48.2 59.7 41.6 28.7 59.7 146.1 95.5 10.4 11.5 124.0 132.1 89.7 66.2 15.8 11.9 25.4 22.4 18.4 77.6 457.6 15.7 69.5 84.4 2.8 68.3 58.9 34.8 314.1 65.3 291.0 12.2 121.1 67.4 7.6 77.3 57.7 40.4 41.7 44.4 138.9 39.0 14.0 102.2 405.6 0.8 3.8 1104.3 354.4 1.5 295.1 42.9 209.9 125.1 186.4 1276.3 0.1 181.6 2857.3 2417.8 498.0 1.0 981.4 208.0 2.3 0.1 0.1 451.6 501.3 718.9 0.7 3.9 2675.6 1915.6 77.9 93.1 827.5 188.1 0.2 0.2 3.8 2269.4 4.8 0.7 0.7 13.1 5.1 0.9 0.4 24.3 3.4 96.7 8.8 1.3 0.7 473.7 15.5 3.9 452.8 3.7 110.9 745.6 1419.3 59.8 1916.3 1139.6 0.3 0.7 1.9 3667.3 0.9 1077.5 1.6 252.3 1.0 0.9 149.1 1.0 1.0 1.0 2.0 156.9 0.4 0.3 1.0 5.3 6.2 121.4 324.5 0.5 108.5 9.5 10.4 10.0 25.5 10.4 11.5 15.8 11.9 15.7 12.2 77.3 14.0 12.4 3.2 21.4 0.0 6.3 119.4 4.8 141.8 4.6 0.4 1.9 5.5 8.9 4.3 21.8 1.8 0.0 9.9 146.5 1.3 0.0 67.5 2.4 2.3 57.9 16.4 3.5 8.8 0.4 112.6 8.5 113.5 0.5 1.7 5.1 0.0 21.0 25.7 251.8 1.7 0.0 7.8 6.1 292.9 251.2 1.9 10.2 198.9 49.8 4.7 151.1 0.3 6.2 0.0 0.0 590.1 0.0 2.2 1.9 1.0 0.1 2.7 8.5 0.2 26.3 156.8 326.1 0.2 0.9 1.9 55.7 19.4 8.5 10.8 0.9 2.5 TGM6 "dJ734P14.3, SCA35, TGM3L, TGY" ENSG00000166948 "Transglutaminase 6" O95932 20 2380901-2432753 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Acyltransferase, Transferase" "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in single" 10 "cerebellum: 1.0" HPA059196 Uncertain NA NA "HPA059196: AB_2683943" "unprognostic (1.18e-1)" "unprognostic (2.84e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TH DYT5b ENSG00000180176 "Tyrosine hydroxylase" P07101 11 2163929-2171815 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Catecholamine biosynthesis, Neurotransmitter biosynthesis" "Monooxygenase, Oxidoreductase" "Disease variant, Dystonia, FDA approved drug targets, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 69 "adrenal gland: 196.6;brain: 270.9" "Cell type enhanced" "Detected in some" "Endometrial stromal cells: 9.0;Extravillous trophoblasts: 12.4;Leydig cells: 3.4;Syncytiotrophoblasts: 2.2" "Cancer enriched" "Detected in some" 5 "urothelial cancer: 4.0" "Group enriched" "Detected in many" 5 "midbrain: 192.4;pons: 270.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 30 "PC-3: 60.8;SK-BR-3: 21.0" "Region enhanced" "Detected in many" "olfactory bulb: 178.8" "Region enriched" "Detected in many" 20 "midbrain: 594.4" "CAB002522, HPA013768, HPA014010, HPA061003, CAB072340" Enhanced Supported Approved Cytosol NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 38: Extravillous trophoblasts - Unknown function" Cytosol "CAB002522: AB_564047, CAB072340: , HPA013768: , HPA014010: , HPA061003: AB_2630374" "unprognostic (1.31e-1)" "unprognostic (1.30e-1)" "unprognostic (9.08e-2)" "unprognostic (1.75e-4)" "unprognostic (8.82e-3)" "unprognostic (5.88e-2)" "unprognostic (1.93e-1)" "unprognostic (1.74e-3)" "unprognostic (3.83e-2)" "unprognostic (4.39e-4)" "unprognostic (4.97e-1)" "unprognostic (3.61e-2)" "unprognostic (1.92e-1)" "unprognostic (1.60e-1)" "unprognostic (2.43e-1)" "unprognostic (2.70e-2)" "unprognostic (2.18e-2)" 3.3 196.6 1.9 0.1 3.0 0.0 0.0 0.2 1.3 0.6 0.2 0.1 0.0 0.5 0.1 0.7 0.2 0.4 0.1 1.3 46.5 0.4 0.4 0.0 0.0 13.9 192.4 0.7 0.2 0.0 1.7 0.1 270.9 0.3 0.0 0.1 0.1 0.0 0.0 0.8 0.5 0.0 0.8 0.2 0.3 0.5 14.6 0.0 0.0 0.0 0.0 1.4 1.5 1.6 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.6 60.8 0.0 0.0 0.0 0.1 0.1 1.1 0.2 0.0 21.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 3.0 0.2 1.3 1.3 46.5 13.9 192.4 270.9 0.8 14.6 1.6 0.3 0.0 0.0 0.0 0.5 0.1 0.1 0.2 0.0 0.0 0.0 0.1 0.9 0.0 0.2 1.8 0.0 0.2 0.0 0.1 0.0 0.1 0.1 0.4 9.0 0.4 0.0 0.0 0.1 0.0 12.4 0.4 0.0 0.3 0.0 0.0 1.1 0.2 0.5 0.0 0.3 0.1 0.0 0.0 0.3 0.2 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.7 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 1.6 0.0 0.0 2.2 0.1 0.3 0.2 0.2 THAP1 "4833431A01Rik, DYT6, FLJ10477" ENSG00000131931 "THAP domain containing 1" Q9NVV9 8 42836674-42843325 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Cell cycle, Transcription, Transcription regulation" DNA-binding "Disease variant, Dystonia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA071310 Supported Nucleoplasm No No "Cluster 15: NK-cells - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" Nucleoplasm "HPA071310: AB_2686386" "unprognostic (8.99e-3)" "unprognostic (3.97e-3)" "unprognostic (7.15e-3)" "unprognostic (1.87e-2)" "unprognostic (2.55e-1)" "unprognostic (6.38e-2)" "unprognostic (1.20e-1)" "unprognostic (4.03e-1)" "unprognostic (3.91e-2)" "unprognostic (5.95e-2)" "unprognostic (9.43e-2)" "unprognostic (9.19e-2)" "unprognostic (2.94e-2)" "unprognostic (1.28e-1)" "unprognostic (2.82e-1)" "unprognostic (1.95e-1)" "unprognostic (3.16e-2)" 7.3 5.7 4.9 6.9 5.1 8.3 7.4 7.3 7.5 6.2 4.9 6.2 5.9 6.9 6.2 6.3 7.3 5.1 8.8 4.9 4.7 7.0 8.7 5.4 9.5 5.2 4.8 8.2 4.6 7.9 3.8 7.0 5.3 5.7 5.4 5.7 6.2 5.7 12.4 4.0 5.8 6.8 5.2 6.3 5.0 9.4 5.2 11.5 8.6 12.5 8.4 6.5 3.7 6.4 10.5 9.3 8.5 8.2 12.7 14.3 10.2 14.2 10.8 12.8 11.7 8.0 13.2 12.8 11.3 10.5 19.0 10.7 14.0 12.0 16.2 12.4 10.3 12.5 8.1 9.4 15.6 10.4 12.7 11.3 17.7 14.1 18.2 12.4 16.5 17.1 14.1 14.7 15.1 6.4 25.1 12.1 16.8 16.9 7.4 11.2 15.2 10.2 13.9 7.8 6.9 8.1 15.5 9.7 20.2 11.2 13.5 11.6 10.0 11.2 8.3 15.0 14.3 11.9 14.0 12.2 11.2 13.6 12.4 23.8 18.6 30.8 19.9 16.7 21.6 20.4 23.1 22.1 19.9 17.8 26.9 21.5 22.0 19.3 18.0 9.8 32.5 18.8 4.9 5.1 7.3 7.5 4.9 4.7 5.2 4.8 5.3 5.2 5.2 6.4 17.2 9.6 9.4 3.6 20.1 13.5 9.4 16.6 26.7 10.5 12.3 11.4 21.5 7.2 12.6 5.5 0.0 20.5 17.5 7.7 23.5 17.5 35.6 16.1 16.2 15.5 14.3 18.3 5.2 11.3 23.8 14.5 2.6 13.3 16.5 8.6 10.4 12.1 15.2 23.5 5.3 8.8 28.5 11.6 9.2 17.9 11.5 13.4 7.2 2.8 20.2 15.6 30.9 5.5 4.9 10.6 4.0 13.9 18.5 10.8 14.1 22.9 13.1 11.0 0.0 12.9 17.0 32.6 45.8 21.1 13.8 8.1 24.6 12.8 9.6 8.2 THG1L "FLJ11601, FLJ20546, hTHG1, ICF45, IHG-1" ENSG00000113272 "TRNA-histidine guanylyltransferase 1 like" Q9NWX6 5 157731420-157741449 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "tRNA processing" "Nucleotidyltransferase, Transferase" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035877, HPA035878" Approved NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 89: Fibroblasts - ECM organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 32: Non-specific - Translation" "HPA035877: AB_10669979, HPA035878: AB_10672993" "unprognostic (4.30e-3)" "unprognostic (2.64e-1)" "unprognostic (3.99e-3)" "unprognostic (2.86e-2)" "unprognostic (1.74e-1)" "unprognostic (4.37e-2)" "unprognostic (5.74e-3)" "unprognostic (4.08e-2)" "unprognostic (1.72e-1)" "unprognostic (7.16e-2)" "unprognostic (1.34e-1)" "unprognostic (4.05e-1)" "prognostic unfavorable (3.93e-6)" "unprognostic (1.48e-1)" "unprognostic (1.47e-1)" "unprognostic (3.09e-1)" "unprognostic (1.69e-1)" 3.8 4.9 2.3 4.0 2.5 5.9 5.3 2.7 2.7 5.2 2.2 6.9 5.5 6.8 5.9 5.0 6.4 4.7 3.4 2.2 2.7 3.5 5.1 3.0 5.4 2.6 2.4 7.6 4.7 3.1 3.2 4.3 2.6 4.0 7.7 3.4 3.1 5.3 3.9 5.4 4.9 5.7 2.1 4.1 5.4 4.9 2.6 5.3 6.7 2.8 6.0 6.4 4.6 3.0 8.8 15.4 7.2 13.8 6.7 19.6 5.5 6.8 12.6 13.7 18.1 21.4 8.7 21.8 5.7 6.0 8.3 9.1 9.0 13.1 15.2 8.9 12.0 7.7 10.2 9.1 7.6 16.6 8.0 17.8 15.4 12.1 16.6 13.0 5.1 3.4 13.8 6.9 8.2 12.1 2.0 11.3 6.9 3.9 14.8 3.3 13.8 12.6 8.5 11.0 9.1 12.8 5.5 8.2 11.3 5.2 13.9 9.5 5.8 10.9 7.2 9.2 18.5 6.0 7.1 14.0 4.8 15.9 6.9 3.9 7.8 0.1 3.3 8.7 3.9 5.7 4.3 3.4 7.0 4.6 6.3 5.3 0.7 6.7 8.7 4.5 5.0 3.9 2.3 2.5 2.7 2.7 2.2 2.7 2.6 2.4 2.6 2.1 2.6 3.0 6.0 3.2 8.6 1.3 14.7 20.6 27.7 27.1 27.9 2.6 14.2 15.4 6.2 11.5 11.5 3.7 4.2 17.6 10.2 6.9 9.8 17.1 19.2 8.8 20.8 9.0 7.2 23.5 1.8 26.4 12.8 15.4 12.2 7.2 2.5 17.3 6.8 8.6 19.1 0.0 1.4 14.3 8.2 15.7 17.9 8.6 14.3 16.2 5.4 1.9 21.2 2.0 7.2 0.5 1.9 12.1 19.6 15.4 13.7 21.2 9.7 14.7 5.8 4.6 6.6 17.1 12.4 19.8 8.9 24.0 15.3 13.8 11.2 38.0 24.1 28.4 TIMM8A "DDP, DFN1, MTS" ENSG00000126953 "Translocase of inner mitochondrial membrane 8A" O60220 X 101345661-101348742 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Protein transport, Translocation, Transport" Chaperone "Deafness, Disease variant, Dystonia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 102.2;Hepatocytes: 68.3;Suprabasal keratinocytes: 88.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HMC-1: 217.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003628 Supported Supported Mitochondria NA NA 59000 "Cluster 30: Non-specific - Translation" "Cluster 8: Non-specific - Mitochondria" "Cluster 3: HMC-1 - Innate immune response" "Cluster 28: Keratinocytes - Keratinization" Mitochondria "HPA003628: AB_1080284" "prognostic unfavorable (7.89e-5)" "unprognostic (1.36e-1)" "unprognostic (2.80e-1)" "prognostic unfavorable (8.87e-5)" "unprognostic (2.06e-1)" "unprognostic (9.28e-3)" "unprognostic (5.14e-3)" "unprognostic (8.32e-2)" "unprognostic (1.90e-2)" "unprognostic (1.86e-3)" "unprognostic (6.41e-2)" "unprognostic (8.57e-3)" "prognostic favorable (1.69e-4)" "unprognostic (1.14e-2)" "unprognostic (7.75e-2)" "unprognostic (1.70e-1)" "unprognostic (3.86e-2)" 5.1 5.6 4.3 6.5 4.4 6.9 7.6 5.1 5.2 4.4 4.8 7.2 6.6 4.2 4.7 7.0 5.6 3.6 10.9 4.5 5.3 9.2 25.3 3.1 8.2 4.5 5.5 5.9 5.2 6.7 1.9 6.3 4.5 6.5 7.5 5.0 6.0 3.7 10.0 6.5 6.3 4.8 5.0 4.5 4.2 3.2 5.2 6.8 6.5 14.0 8.7 6.5 3.1 4.3 31.5 30.0 17.1 33.8 13.3 15.0 20.3 23.5 11.4 20.0 40.6 26.4 21.3 38.0 29.7 17.8 36.5 27.7 46.2 24.5 33.3 17.7 29.9 62.8 44.7 46.5 12.7 39.9 217.8 15.0 21.5 30.0 18.8 9.6 19.7 15.9 51.0 40.8 26.8 50.7 18.3 39.1 55.3 46.4 49.3 30.2 31.1 44.9 18.3 21.1 22.7 20.9 28.6 22.8 22.5 18.8 19.1 19.3 14.2 27.5 31.5 40.6 26.1 18.7 50.8 45.9 14.6 53.8 22.2 1.2 3.8 0.2 4.9 5.8 7.0 12.1 6.8 7.2 4.6 11.9 10.3 8.4 0.4 5.2 3.1 11.7 3.8 4.3 4.3 4.4 5.1 5.2 4.5 5.3 4.5 5.5 4.5 5.0 5.2 4.3 7.0 3.2 4.4 1.3 10.7 102.2 39.6 27.6 31.9 7.6 11.2 16.8 25.8 5.7 14.1 11.0 6.2 38.4 8.7 7.5 39.2 13.5 0.7 9.0 10.8 10.2 8.4 27.4 2.8 10.9 47.6 13.0 7.1 7.3 16.5 9.3 5.3 68.3 21.1 3.3 2.8 8.6 22.4 7.2 13.9 0.5 6.5 7.5 14.2 1.9 5.0 5.4 3.1 1.0 0.7 15.4 6.7 2.6 13.8 36.2 8.0 39.9 9.1 8.5 0.0 9.6 16.7 2.9 10.9 27.7 88.5 36.7 6.9 12.4 18.0 27.8 TIMP3 SFD ENSG00000100234 "TIMP metallopeptidase inhibitor 3" P35625 22 32801705-32863041 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted secreted proteins" "Sensory transduction, Vision" "Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 1663.5;Fibroblasts: 967.5;Leydig cells: 1398.6;Peritubular cells: 1934.1;Sertoli cells: 2327.1;Smooth muscle cells: 1116.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 502.6;BJ: 1173.0;BJ hTERT+: 514.7;fHDF/TERT166: 1073.7;WM-115: 893.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA068391 Approved "Golgi apparatus,Vesicles" "Secreted to extracellular matrix" NA NA 700000 "Cluster 82: Adipose tissue - ECM organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 48: Smooth muscle cells - ECM organization" Vesicles "Golgi apparatus" "HPA068391: " "unprognostic (4.98e-2)" "unprognostic (1.77e-3)" "unprognostic (1.60e-1)" "unprognostic (8.53e-4)" "unprognostic (1.67e-2)" "unprognostic (1.05e-2)" "unprognostic (7.01e-2)" "unprognostic (3.22e-2)" "unprognostic (8.42e-2)" "prognostic unfavorable (1.90e-5)" "unprognostic (3.92e-1)" "unprognostic (1.95e-1)" "prognostic favorable (1.50e-4)" "unprognostic (2.66e-3)" "unprognostic (1.44e-2)" "unprognostic (2.55e-3)" "unprognostic (3.11e-2)" 805.5 288.7 71.7 41.4 74.9 1.1 556.9 68.7 72.6 376.1 221.0 190.4 30.5 393.3 230.4 168.1 373.9 153.5 532.8 64.3 79.2 248.0 92.0 625.1 69.5 83.2 86.7 116.2 81.1 139.5 139.1 999.5 76.0 178.8 81.2 31.7 178.7 341.1 128.1 170.3 122.1 379.6 70.3 187.2 152.1 64.1 106.2 41.1 340.1 325.9 28.8 197.4 261.1 59.5 19.6 0.0 16.9 2.7 502.6 280.6 1.0 1173.0 514.7 94.1 110.8 20.5 0.3 0.1 28.1 1073.7 3.6 18.3 3.2 48.4 135.0 0.1 14.3 147.4 23.5 52.4 197.4 0.1 59.7 47.4 120.4 166.9 9.5 3.4 0.0 0.0 0.1 0.9 44.6 1.2 0.4 5.0 2.5 0.0 0.8 0.1 3.4 0.4 2.1 97.0 12.5 16.8 24.1 0.5 322.9 266.6 0.7 1.3 0.0 7.9 25.2 245.9 19.1 0.2 0.4 0.4 232.3 0.2 893.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 71.7 74.9 68.7 72.6 64.3 79.2 83.2 86.7 76.0 70.3 106.2 59.5 1663.5 365.4 35.9 101.9 5.3 77.4 766.2 49.5 10.2 4.0 31.2 177.2 279.9 14.3 22.2 51.5 4.2 492.2 4.6 0.3 3.9 2.5 14.9 27.9 747.6 677.3 1.8 35.3 26.1 0.7 433.7 967.5 21.4 23.9 89.2 11.4 743.9 102.0 109.2 3.3 15.7 0.0 24.4 39.3 95.0 57.7 1398.6 28.6 76.5 116.2 0.7 146.6 0.0 52.3 0.8 0.9 0.0 1934.1 9.5 159.5 0.0 15.5 8.5 5.5 2327.1 339.2 1116.6 6.2 7.0 14.3 56.4 809.0 21.5 4.8 0.7 163.4 TLR4 "ARMD10, CD284, hToll, TLR-4" ENSG00000136869 "Toll like receptor 4" O00206 9 117704175-117724735 "CD markers, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Immunity, Inflammatory response, Innate immunity" "Hydrolase, Receptor" "Age-related macular degeneration, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 38.6;Astrocytes: 50.9;Hepatic stellate cells: 62.8;Hofbauer cells: 38.2;Kupffer cells: 106.0;Macrophages: 64.5;monocytes: 54.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 86.8" "Group enriched" "Detected in many" 33 "dendritic cells: 22.4;granulocytes: 86.8;monocytes: 65.6" "Cell line enhanced" "Detected in many" "Karpas-707: 60.0;TIME: 43.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "CAB004025, HPA049174" Approved Supported "Golgi apparatus,Plasma membrane" "Intracellular and membrane" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 2: Karpas-707 - Immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "Plasma membrane" "Golgi apparatus" "CAB004025: , HPA049174: AB_2680662" "unprognostic (1.60e-1)" "unprognostic (8.34e-2)" "unprognostic (7.22e-2)" "prognostic favorable (6.29e-4)" "unprognostic (3.39e-1)" "unprognostic (7.48e-2)" "unprognostic (8.68e-2)" "unprognostic (1.80e-1)" "unprognostic (3.38e-1)" "unprognostic (5.18e-2)" "unprognostic (8.00e-2)" "unprognostic (9.42e-2)" "unprognostic (4.08e-2)" "unprognostic (8.63e-2)" "prognostic unfavorable (3.79e-4)" "unprognostic (1.09e-2)" "unprognostic (1.96e-2)" 31.1 11.0 12.4 25.7 15.7 22.3 12.0 11.7 8.3 6.5 1.7 6.7 4.3 5.6 1.2 4.8 4.8 10.8 8.4 10.3 17.8 6.8 16.7 16.2 13.1 12.3 14.0 6.0 2.6 2.5 2.1 23.9 12.4 4.6 7.3 2.9 6.0 3.2 3.1 3.5 5.8 10.8 14.9 32.6 4.4 1.5 14.2 3.5 5.5 12.0 7.7 13.3 2.7 10.1 0.0 0.0 25.5 0.0 11.1 23.0 0.1 10.2 17.9 2.5 1.5 0.0 2.6 3.6 0.5 26.7 7.5 0.1 0.0 2.2 3.7 0.0 0.0 5.7 5.1 0.4 8.1 19.1 0.1 14.2 0.0 5.4 0.7 22.5 31.4 0.0 0.0 60.0 29.2 0.0 0.0 2.9 3.1 2.4 1.2 0.0 28.0 19.8 0.9 28.9 0.0 0.1 6.4 0.0 1.0 2.2 0.0 10.4 43.5 1.4 18.4 0.1 4.8 0.0 0.0 0.0 0.9 19.1 15.2 64.0 64.9 21.5 0.1 57.5 0.0 1.7 0.1 0.0 22.4 0.5 0.0 0.0 86.8 0.1 65.6 0.9 0.0 25.5 12.4 15.7 11.7 8.3 10.3 17.8 12.3 14.0 12.4 14.9 14.2 10.1 38.6 0.0 5.0 50.9 2.3 0.8 0.3 0.1 0.6 0.2 3.5 1.0 2.9 2.8 2.9 0.0 0.0 0.3 0.1 1.6 0.0 0.1 0.1 3.5 29.2 31.6 0.0 1.3 0.2 0.2 0.2 11.5 1.5 6.8 15.8 1.2 62.8 1.9 38.2 0.0 0.2 2.0 0.0 106.0 8.6 0.4 0.0 64.5 1.8 26.2 54.0 8.8 2.1 7.5 0.3 0.5 6.1 0.0 0.1 0.1 0.0 0.4 3.7 1.3 6.6 5.5 4.5 0.1 0.3 0.3 0.0 0.8 0.9 3.1 1.2 3.3 TMC1 "DFNA36, DFNB11, DFNB7" ENSG00000165091 "Transmembrane channel like 1" Q8TDI8 9 72521608-72838297 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Hearing, Ion transport, Transport" "Ion channel" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in single" "cervix: 1.0" "Cell type enhanced" "Detected in some" "Astrocytes: 19.2;Early spermatids: 7.9;Endometrial stromal cells: 5.5;Microglial cells: 5.6;Urothelial cells: 6.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 2.7;HAP1: 5.2;NTERA-2: 1.9;SuSa: 1.0;U-266/70: 1.3;U-266/84: 1.4" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 5: NTERA-2 - Transcription" "Cluster 64: Astrocytes - Nervous system maintenance" "unprognostic (6.36e-2)" "unprognostic (1.45e-1)" "unprognostic (1.79e-1)" "unprognostic (7.19e-3)" "unprognostic (3.97e-1)" "unprognostic (5.67e-4)" "unprognostic (1.63e-1)" "unprognostic (1.91e-1)" "unprognostic (2.10e-2)" "unprognostic (3.74e-1)" "unprognostic (3.94e-2)" "unprognostic (2.12e-1)" "unprognostic (2.67e-3)" "unprognostic (1.80e-1)" "unprognostic (2.35e-1)" "unprognostic (3.94e-2)" "unprognostic (1.31e-1)" 0.0 0.0 0.4 0.0 0.4 0.0 0.0 0.5 0.5 1.0 0.1 0.0 0.0 0.1 0.8 0.1 0.1 0.0 0.0 0.4 0.6 0.7 0.0 0.0 0.0 0.6 0.6 0.0 0.0 0.0 0.0 0.4 0.6 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.3 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 5.2 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.4 0.5 0.5 0.4 0.6 0.6 0.6 0.6 0.5 0.4 0.7 1.3 0.0 0.0 19.2 0.0 0.3 2.9 0.1 0.6 0.2 0.1 0.1 0.4 0.0 0.0 1.8 0.0 4.0 0.1 0.4 0.0 0.2 7.9 1.4 5.5 1.2 0.0 0.0 1.5 0.6 2.8 0.3 0.0 0.9 0.0 0.0 0.0 0.0 0.5 0.0 1.2 0.0 0.0 0.0 0.0 2.6 0.3 0.1 0.0 5.6 0.6 1.1 0.0 1.5 1.3 0.5 2.2 0.0 0.0 3.1 0.0 3.0 0.0 0.0 0.0 0.3 0.2 1.8 3.1 0.5 0.0 2.6 0.1 0.5 0.0 6.8 TMEM126A "DKFZp586C1924, OPA7" ENSG00000171202 "Transmembrane protein 126A" Q9H061 11 85647967-85656547 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046648 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 39: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 39: Non-specific - Basic cellular processes" Cytosol Nucleoplasm "HPA046648: AB_2679737" "unprognostic (3.79e-2)" "unprognostic (4.75e-3)" "unprognostic (2.08e-3)" "unprognostic (1.08e-3)" "unprognostic (2.08e-1)" "unprognostic (1.79e-1)" "prognostic unfavorable (8.60e-5)" "unprognostic (8.25e-2)" "unprognostic (6.00e-3)" "unprognostic (2.66e-2)" "unprognostic (1.02e-2)" "unprognostic (6.93e-2)" "unprognostic (1.25e-1)" "unprognostic (1.87e-2)" "unprognostic (2.70e-1)" "unprognostic (6.94e-2)" "unprognostic (2.17e-1)" 31.9 28.0 40.3 23.1 41.5 43.8 33.5 41.4 52.3 21.8 39.5 28.0 32.6 20.0 31.2 27.2 19.8 19.9 82.1 41.4 42.3 33.1 49.0 20.5 27.3 40.7 40.6 21.0 33.9 26.3 22.2 22.8 41.5 23.5 29.3 23.9 31.3 19.5 81.6 19.4 26.0 27.6 41.1 21.0 32.8 38.5 41.4 24.2 26.6 98.7 27.8 30.5 20.1 42.4 46.7 53.2 50.9 33.0 67.2 66.7 38.0 55.9 60.1 82.3 77.6 65.9 67.5 25.4 61.3 69.2 32.0 48.9 53.8 59.5 70.7 72.5 31.0 72.5 56.9 73.7 82.4 89.0 54.8 58.0 65.8 73.1 78.0 43.5 71.6 72.2 51.1 39.0 86.2 57.5 48.6 112.3 48.1 175.1 68.4 48.3 49.5 79.2 54.5 57.0 34.3 34.7 49.4 72.9 44.7 44.5 88.1 64.4 42.8 70.4 52.7 134.6 65.3 27.5 54.4 70.4 37.0 63.6 85.2 6.6 23.9 11.6 21.2 28.1 26.0 29.8 26.4 23.8 32.9 27.3 24.4 24.1 1.9 15.1 23.4 24.7 26.4 18.7 40.3 41.5 41.4 52.3 41.4 42.3 40.7 40.6 41.5 41.1 41.4 42.4 40.5 28.9 24.3 12.7 39.6 31.7 55.3 87.9 29.6 14.8 45.8 62.1 110.8 28.6 57.5 38.6 6.2 67.8 38.5 23.6 146.8 51.0 147.8 26.8 32.8 36.7 21.7 46.1 8.6 93.2 73.3 40.8 23.4 24.2 37.4 33.6 26.7 68.5 94.6 8.4 9.0 46.6 40.7 54.4 43.3 80.6 29.5 48.4 33.8 5.6 66.3 35.1 38.1 8.5 11.8 64.5 34.8 26.7 45.4 73.4 61.8 109.4 39.7 21.9 19.7 40.0 40.9 119.0 57.9 49.4 42.1 52.9 42.1 42.2 57.1 71.2 TMEM132E DFNB99 ENSG00000181291 "Transmembrane protein 132E" Q6IEE7 17 34579487-34639318 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "brain: 17.9" "Cell type enhanced" "Detected in some" "Excitatory neurons: 4.1;Inhibitory neurons: 6.4;Oligodendrocyte precursor cells: 13.0;Proximal tubular cells: 11.5" "Cancer enriched" "Detected in some" 4 "glioma: 7.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 9 "RPMI-8226: 37.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA070608 Approved Approved "Nucleoplasm,Nuclear bodies,Golgi apparatus,Cytosol" NA NA 170000 "Cluster 40: NK-cells - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 25: RPMI-8226 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nucleoplasm, Golgi apparatus" "Nuclear bodies, Cytosol" "HPA070608: AB_2686286" "unprognostic (1.92e-1)" "unprognostic (1.68e-1)" "unprognostic (3.29e-5)" "unprognostic (3.37e-1)" "unprognostic (1.37e-1)" "unprognostic (8.61e-2)" "unprognostic (1.06e-3)" "unprognostic (1.72e-1)" "unprognostic (1.80e-1)" "unprognostic (1.56e-2)" "unprognostic (2.16e-3)" "unprognostic (1.25e-1)" "prognostic unfavorable (1.55e-4)" "unprognostic (1.67e-2)" "unprognostic (1.51e-2)" "unprognostic (2.65e-1)" "unprognostic (8.71e-2)" 0.3 0.1 4.6 0.0 3.0 0.0 0.1 6.1 6.4 0.4 0.0 0.1 1.2 0.1 0.0 0.1 0.1 0.1 0.5 2.6 6.2 3.6 0.4 0.1 0.1 17.9 5.1 0.2 0.0 0.0 0.1 0.1 10.2 0.1 0.0 0.1 0.2 0.1 0.0 0.1 0.7 0.1 8.7 0.3 0.1 1.9 6.5 0.0 0.2 0.0 0.1 0.1 0.2 11.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 1.1 4.3 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 37.4 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.3 0.0 0.2 0.0 0.0 0.0 0.0 4.6 3.0 6.1 6.4 2.6 6.2 17.9 5.1 10.2 8.7 6.5 11.1 0.1 0.0 0.0 2.6 0.1 0.3 0.0 0.0 0.0 1.9 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.1 0.0 0.0 4.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 6.4 0.0 0.0 1.9 0.7 2.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 13.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 11.5 0.0 0.1 0.0 0.2 0.5 1.2 2.5 0.0 0.0 0.0 0.3 0.0 0.0 0.0 TMEM240 "C1orf70, SCA21" ENSG00000205090 "Transmembrane protein 240" Q5SV17 1 1534778-1540624 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Disease variant, Mental retardation, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in some" "Astrocytes: 6.5;Excitatory neurons: 15.5;Inhibitory neurons: 15.1;Oligodendrocyte precursor cells: 8.0;Sertoli cells: 6.6" "Cancer enhanced" "Detected in many" "glioma: 3.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HEK 293: 8.5;SCLC-21H: 9.3;SH-SY5Y: 11.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA066721 Supported NA NA "Cluster 35: Non-specific - Unknown function" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA066721: AB_2732750" "unprognostic (2.24e-1)" "unprognostic (1.87e-1)" "unprognostic (5.52e-5)" "unprognostic (2.31e-1)" "unprognostic (2.47e-1)" "unprognostic (1.01e-1)" "unprognostic (1.37e-1)" "unprognostic (3.85e-2)" "unprognostic (3.48e-2)" "unprognostic (1.21e-1)" "prognostic favorable (2.52e-4)" "unprognostic (9.13e-2)" "unprognostic (7.96e-3)" "unprognostic (9.50e-4)" "unprognostic (2.64e-1)" "unprognostic (8.38e-2)" "unprognostic (1.93e-1)" 4.1 3.5 10.9 0.6 12.2 0.1 3.9 17.1 22.8 14.8 2.5 17.4 0.4 15.1 0.9 2.9 10.6 1.0 8.2 13.1 7.6 3.6 1.2 4.2 0.4 7.1 8.1 16.1 1.3 1.4 15.1 1.6 7.3 9.5 0.5 1.3 2.5 3.3 3.8 2.7 4.9 2.1 5.4 4.0 5.7 3.0 8.5 0.3 5.3 1.2 0.2 10.8 8.6 9.6 0.9 1.0 5.7 0.7 0.8 3.8 1.4 3.8 2.1 3.5 2.0 0.0 0.4 0.7 0.7 1.9 0.2 2.2 0.0 0.2 0.5 3.5 8.5 0.5 3.6 1.3 7.5 0.0 0.8 5.2 1.8 1.4 0.3 4.3 3.5 0.6 1.1 0.3 0.0 0.2 0.6 0.9 3.9 0.1 1.2 3.3 1.1 0.7 0.4 0.0 9.3 11.2 1.4 0.4 4.0 0.1 0.6 0.0 1.9 0.5 1.7 0.7 1.7 1.6 0.4 0.4 1.9 2.6 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.9 12.2 17.1 22.8 13.1 7.6 7.1 8.1 7.3 5.4 8.5 9.6 0.7 0.0 0.0 6.5 0.2 0.0 0.3 0.0 1.2 3.1 0.4 0.5 0.5 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.0 0.1 0.0 0.2 1.6 0.4 0.0 0.0 15.5 0.0 0.1 0.8 0.0 0.2 0.0 1.6 0.7 0.0 0.1 3.3 15.1 0.6 0.0 0.0 0.0 0.0 1.2 0.2 0.0 1.0 0.0 4.5 1.0 8.0 4.4 0.1 0.2 2.2 0.3 0.2 0.1 0.1 0.0 0.5 6.6 0.2 0.9 0.1 0.5 0.1 0.0 0.0 0.2 1.4 0.3 0.1 TMIE DFNB6 ENSG00000181585 "Transmembrane inner ear" Q8NEW7 3 46694528-46710886 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 19.6;choroid plexus: 10.5;pituitary gland: 9.9" "Cell type enhanced" "Detected in some" "Bipolar cells: 3.8;Spermatocytes: 2.6;Spermatogonia: 3.2" "Cancer enriched" "Detected in many" 5 "glioma: 6.6" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "naive CD4 T-cell: 2.4" "Lineage enriched" "Detected in single" 15 "T-cells: 2.4" "Cell line enhanced" "Detected in some" "CAPAN-2: 3.1;EFO-21: 2.7;JURKAT: 10.7;SH-SY5Y: 2.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA038298 Uncertain Uncertain Vesicles,Cytosol NA NA "Cluster 32: T-cells - Unknown function" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 56: Bipolar cells - Visual perception" "Vesicles, Cytosol" "HPA038298: AB_10675792" "unprognostic (6.59e-2)" "unprognostic (1.11e-1)" "unprognostic (7.25e-3)" "unprognostic (2.48e-3)" "unprognostic (1.88e-2)" "unprognostic (5.40e-3)" "unprognostic (3.94e-2)" "unprognostic (8.80e-2)" "unprognostic (3.37e-2)" "unprognostic (6.65e-2)" "unprognostic (1.97e-1)" "unprognostic (5.35e-2)" "unprognostic (4.58e-2)" "unprognostic (1.23e-1)" "unprognostic (4.41e-2)" "unprognostic (5.29e-2)" "unprognostic (6.78e-2)" 0.7 6.2 14.2 0.5 14.1 0.0 0.4 14.0 18.0 0.7 10.5 1.0 0.4 0.5 0.7 1.5 0.6 0.2 0.7 14.1 19.3 2.3 0.8 1.0 0.8 19.6 15.7 1.5 0.2 0.1 9.9 0.4 19.2 0.5 0.3 0.7 0.5 1.0 3.6 0.7 0.5 0.4 16.0 0.7 0.3 1.5 18.7 0.5 0.9 1.2 0.8 0.6 0.9 14.9 1.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 3.1 0.0 2.7 0.0 0.5 0.1 0.1 0.2 0.0 0.0 0.0 0.8 0.0 0.0 0.8 0.0 0.0 0.0 1.8 0.0 1.2 0.0 0.5 10.7 0.0 0.2 0.0 0.1 0.0 0.0 0.2 0.7 0.1 1.2 0.0 0.3 0.1 0.1 0.3 2.3 0.3 0.3 0.0 0.1 0.0 0.5 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.4 0.1 0.0 2.4 0.4 0.0 0.0 0.0 0.0 0.4 0.4 14.2 14.1 14.0 18.0 14.1 19.3 19.6 15.7 19.2 16.0 18.7 14.9 1.9 0.0 0.0 0.3 0.0 0.8 0.2 0.5 0.0 3.8 0.2 0.6 0.9 0.0 0.3 0.0 0.0 0.0 0.0 0.1 1.9 0.4 0.5 0.2 0.0 0.7 0.0 0.0 1.7 0.4 0.1 0.4 0.0 0.1 0.0 0.1 0.4 0.1 0.6 0.0 0.8 0.0 0.0 0.0 0.4 1.5 0.6 0.3 0.0 1.9 0.1 1.4 0.0 0.0 0.3 1.2 0.0 0.4 0.0 0.3 0.0 0.0 0.6 0.5 0.0 1.1 1.0 2.6 3.2 0.0 0.9 0.1 0.2 0.1 0.0 0.2 TMPRSS3 "DFNB10, DFNB8" ENSG00000160183 "Transmembrane serine protease 3" P57727 21 42371887-42396091 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Hydrolase, Protease, Serine protease" "Cancer-related genes, Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "fallopian tube: 23.7;stomach 1: 14.5" "Cell type enhanced" "Detected in many" "Breast glandular cells: 17.7;Cholangiocytes: 24.3;Ductal cells: 16.1;Endometrial ciliated cells: 17.1;Gastric mucus-secreting cells: 23.4;Ionocytes: 16.2;Muller glia cells: 20.4;Respiratory ciliated cells: 39.8" "Cancer enhanced" "Detected in many" "ovarian cancer: 16.6" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "MAIT T-cell: 3.1" "Lineage enriched" "Detected in single" 6 "T-cells: 3.1" "Cell line enriched" "Detected in some" 4 "U-266/84: 274.7" "Not detected" "Not detected" "Low region specificity" "Detected in single" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 16: U-266 - Nucleosome" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "unprognostic (8.47e-3)" "unprognostic (2.83e-1)" "prognostic unfavorable (3.64e-4)" "unprognostic (2.85e-1)" "unprognostic (2.45e-3)" "unprognostic (3.97e-2)" "unprognostic (1.43e-1)" "unprognostic (8.17e-2)" "unprognostic (9.62e-2)" "unprognostic (4.81e-2)" "unprognostic (2.65e-1)" "unprognostic (1.42e-1)" "prognostic unfavorable (8.24e-4)" "unprognostic (2.66e-2)" "unprognostic (2.73e-1)" "unprognostic (8.00e-2)" "unprognostic (1.33e-1)" 0.5 0.3 3.8 0.2 4.0 0.1 8.7 4.0 3.7 6.3 2.0 0.2 1.3 0.7 0.0 0.2 23.7 8.6 0.0 3.4 4.1 2.4 0.5 3.4 0.5 4.9 4.7 0.0 3.0 0.0 1.5 0.2 3.7 0.4 0.1 3.9 9.2 0.4 0.1 0.1 1.1 0.0 3.5 0.4 14.5 0.0 4.7 0.9 2.9 0.0 0.4 1.0 0.0 2.7 4.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 12.5 0.0 0.7 0.0 0.3 0.0 0.0 0.0 0.0 32.9 0.0 66.2 26.5 0.7 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 8.6 0.0 14.0 0.0 1.5 3.5 0.0 0.0 1.0 0.4 0.0 0.0 0.0 2.8 1.5 0.0 0.0 33.9 1.6 0.0 0.0 3.2 0.3 0.1 0.0 1.7 0.0 0.2 0.7 274.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.1 3.1 0.0 1.7 1.8 0.0 0.0 0.3 0.9 0.3 0.0 0.5 0.0 0.8 0.5 3.8 4.0 4.0 3.7 3.4 4.1 4.9 4.7 3.7 3.5 4.7 2.7 0.1 12.8 3.7 2.3 0.4 0.3 2.3 8.1 0.0 0.2 17.7 9.9 0.6 24.3 10.8 7.3 0.0 0.0 0.1 1.4 5.9 16.1 1.4 17.1 0.4 0.2 0.0 2.7 0.0 13.8 0.1 1.3 23.4 5.2 0.0 0.2 0.4 0.0 0.1 0.0 0.0 2.0 16.2 0.0 0.5 0.6 0.3 0.3 0.0 0.0 0.0 20.4 0.0 0.0 0.1 11.8 1.4 0.0 0.4 2.4 2.9 0.0 39.8 0.9 0.0 0.0 0.7 0.0 0.0 0.0 0.1 0.0 1.4 0.1 2.5 5.0 TNC "DFNA56, HXB, MGC167029, TN" ENSG00000041982 "Tenascin C" P24821 9 115019575-115118257 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Cell adhesion" "Cancer-related genes, Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "smooth muscle: 376.2" "Cell type enhanced" "Detected in many" "Astrocytes: 160.3;Basal prostatic cells: 72.1;Basal respiratory cells: 150.6;Basal squamous epithelial cells: 126.3;Prostatic glandular cells: 69.2;Smooth muscle cells: 58.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ hTERT+: 798.5;hTEC/SVTERT24-B: 634.4;U-138 MG: 526.0;U-251 MG: 484.5;U-87 MG: 711.8;WM-115: 1253.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB004592, HPA004823" Approved "Secreted to extracellular matrix" NA NA 560000000 840000000 "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 17: WM-115 - Nervous system development" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "CAB004592: AB_628342, HPA004823: AB_1080243" "unprognostic (5.46e-2)" "unprognostic (3.76e-2)" "unprognostic (7.57e-2)" "unprognostic (1.69e-1)" "unprognostic (9.20e-2)" "unprognostic (1.39e-1)" "unprognostic (2.07e-1)" "unprognostic (9.68e-2)" "unprognostic (7.86e-3)" "unprognostic (2.68e-3)" "unprognostic (1.59e-2)" "unprognostic (1.82e-1)" "unprognostic (4.87e-3)" "unprognostic (1.79e-2)" "unprognostic (1.92e-2)" "unprognostic (7.60e-2)" "unprognostic (1.97e-3)" 61.0 4.7 16.4 170.4 28.5 0.9 41.2 14.0 9.8 43.6 3.0 174.3 16.7 106.8 12.2 23.9 25.5 14.1 32.6 15.6 34.3 82.0 7.7 54.2 39.8 20.3 43.8 5.3 4.8 2.3 7.2 4.0 28.0 39.1 28.3 4.8 19.8 33.3 6.2 25.9 56.5 376.2 15.0 40.8 62.4 4.8 65.4 17.1 13.3 3.2 22.6 96.7 15.9 20.5 25.1 6.0 6.9 1.3 37.5 10.1 0.1 205.7 798.5 425.4 203.6 5.3 55.3 0.0 32.8 291.7 6.9 89.9 0.0 12.0 241.3 0.4 2.2 0.0 4.8 0.0 0.7 0.4 3.9 6.2 1.7 634.4 289.9 42.9 0.1 0.0 0.0 5.2 11.4 0.0 0.1 0.3 65.2 0.9 85.3 0.2 451.9 0.1 373.3 0.1 0.6 5.9 91.4 0.2 19.3 140.9 1.0 1.4 0.1 526.0 88.4 94.2 484.5 14.3 0.4 0.4 711.8 0.6 1253.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 16.4 28.5 14.0 9.8 15.6 34.3 20.3 43.8 28.0 15.0 65.4 20.5 0.7 12.8 43.5 160.3 0.4 12.1 72.1 150.6 126.3 0.1 9.3 33.3 1.4 0.0 14.8 1.8 0.0 1.1 0.3 0.0 0.0 25.8 15.4 6.7 47.8 11.1 0.0 0.0 7.0 4.5 0.6 19.0 0.0 24.9 2.5 0.5 6.1 0.0 1.2 0.0 0.9 0.0 0.0 0.6 4.7 18.4 3.4 0.9 5.4 1.9 0.1 1.3 0.0 4.0 0.8 3.9 0.0 0.4 0.3 69.2 0.0 0.3 3.5 0.2 0.0 1.3 58.9 0.4 0.2 4.8 4.5 1.0 2.6 0.1 0.1 5.8 TNFRSF1A "CD120a, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR60" ENSG00000067182 "TNF receptor superfamily member 1A" P19438 12 6328757-6342114 "Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins" "Apoptosis, Host-virus interaction" Receptor "Amyloidosis, Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 507.2" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004102, CAB010309" Approved "Secreted to blood" NA NA 17700 570000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 85: Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB010309: AB_2206639, HPA004102: AB_1846232" "unprognostic (2.19e-2)" "unprognostic (3.76e-2)" "unprognostic (8.14e-2)" "prognostic favorable (8.22e-4)" "unprognostic (3.07e-2)" "prognostic unfavorable (3.68e-4)" "unprognostic (1.50e-1)" "unprognostic (1.41e-3)" "unprognostic (1.00e-1)" "unprognostic (8.05e-2)" "unprognostic (4.78e-2)" "unprognostic (1.54e-2)" "prognostic unfavorable (2.70e-7)" "unprognostic (1.43e-2)" "unprognostic (2.92e-2)" "unprognostic (5.14e-3)" "unprognostic (1.74e-1)" 166.5 133.3 33.7 76.7 34.4 42.4 120.0 35.3 38.6 105.0 47.8 114.1 101.5 111.8 23.0 105.6 106.7 88.8 80.6 32.4 40.3 94.5 176.5 130.7 38.1 45.7 40.4 90.6 57.3 53.7 57.3 82.4 39.6 86.9 56.4 3.5 76.0 46.3 91.0 103.7 109.5 97.5 40.4 111.3 84.4 22.6 39.7 39.2 97.4 63.1 36.1 113.2 113.2 37.4 40.2 296.4 40.9 60.2 277.7 282.0 75.7 82.2 143.0 108.2 93.9 34.7 153.6 3.7 28.9 179.3 85.6 107.1 12.9 96.4 74.1 0.8 25.3 20.3 79.2 82.2 245.5 104.4 66.9 291.8 94.4 90.2 131.4 250.4 134.1 42.0 33.7 29.8 126.3 57.1 34.0 100.0 102.1 146.1 87.6 27.9 66.6 32.4 83.7 70.7 0.1 2.1 117.8 60.9 62.5 103.6 16.4 111.4 146.0 84.6 71.7 64.7 78.4 0.1 10.6 12.8 100.5 95.9 107.0 17.1 165.8 93.5 62.2 130.4 60.0 0.5 25.1 51.0 123.7 0.4 22.3 34.0 507.2 9.7 111.5 31.6 26.2 117.3 33.7 34.4 35.3 38.6 32.4 40.3 45.7 40.4 39.6 40.4 39.7 37.4 102.0 51.3 37.1 15.3 4.8 123.0 115.8 127.3 81.4 0.4 50.1 35.9 9.3 67.2 70.8 27.6 0.0 62.0 35.5 204.0 15.6 98.7 1.2 25.5 66.5 111.8 33.6 30.1 4.6 119.4 120.2 109.3 43.8 42.3 7.6 27.6 159.2 145.0 176.4 0.0 1.3 56.8 32.6 146.7 113.4 5.4 102.2 102.4 71.2 32.8 127.1 15.9 104.0 11.1 0.9 116.6 239.4 65.8 4.2 141.2 227.5 96.9 30.8 0.7 124.9 64.1 89.4 1.3 1.1 57.0 134.7 148.6 31.2 21.5 57.4 140.1 TNRC6A "CAGH26, GW182, KIAA1460, TNRC6" ENSG00000090905 "Trinucleotide repeat containing adaptor 6A" Q8NDV7 16 24610209-24827632 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "RNA-mediated gene silencing, Translation regulation" RNA-binding Epilepsy "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 289.3;Excitatory neurons: 283.8;Inhibitory neurons: 414.6;Oligodendrocyte precursor cells: 265.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015305, HPA017869" Approved Approved "Nucleoplasm,Golgi apparatus,Vesicles" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 72: Non-specific - Transcription" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Golgi apparatus, Vesicles" "HPA015305: AB_1850454, HPA017869: AB_1850456" "unprognostic (2.64e-1)" "unprognostic (2.11e-1)" "unprognostic (1.77e-1)" "unprognostic (1.86e-1)" "unprognostic (5.00e-2)" "unprognostic (1.10e-3)" "unprognostic (1.62e-1)" "unprognostic (3.22e-3)" "unprognostic (5.49e-2)" "unprognostic (2.74e-1)" "unprognostic (7.44e-3)" "unprognostic (2.63e-3)" "unprognostic (1.78e-1)" "unprognostic (9.18e-2)" "unprognostic (5.77e-2)" "unprognostic (2.31e-1)" "unprognostic (3.35e-2)" 17.2 21.0 5.0 6.4 3.6 6.0 14.9 10.8 7.1 17.8 6.1 17.8 5.5 23.5 11.5 11.3 17.7 6.4 11.1 3.4 6.6 10.3 13.0 12.8 7.1 6.1 4.8 20.6 19.2 13.2 22.8 6.6 6.1 14.6 6.4 7.0 14.9 8.0 14.0 13.1 15.3 8.1 2.2 9.9 15.2 6.6 7.0 8.6 17.8 6.9 7.4 13.0 13.4 7.4 10.1 13.8 16.0 8.7 13.6 17.7 9.1 16.9 13.6 12.0 13.1 10.2 8.2 10.2 7.1 17.0 12.4 11.2 20.1 14.2 18.0 10.4 10.4 10.2 16.7 14.1 11.7 10.5 6.9 18.0 7.3 15.8 10.2 14.8 16.7 6.6 15.7 6.2 15.8 11.9 8.8 6.9 23.1 4.9 6.8 17.1 12.4 9.1 9.1 9.3 7.7 10.8 11.8 7.2 6.6 12.1 8.4 6.8 15.5 15.3 10.5 7.6 12.0 13.7 11.6 16.5 14.3 6.4 11.3 0.5 0.5 0.4 0.5 0.3 0.4 1.1 0.5 0.5 0.2 1.0 0.7 0.5 0.3 0.6 0.3 1.0 0.5 0.3 5.0 3.6 10.8 7.1 3.4 6.6 6.1 4.8 6.1 2.2 7.0 7.4 51.2 38.5 60.0 289.3 45.5 34.9 17.8 21.9 39.9 97.1 42.8 41.0 75.3 51.5 32.3 46.0 118.9 22.4 49.9 38.3 17.6 23.6 17.2 38.7 65.5 45.5 55.9 34.9 283.8 24.5 15.1 50.5 33.6 42.8 39.3 76.5 60.3 115.3 21.2 176.7 414.6 36.3 22.4 56.2 26.5 11.3 69.0 28.7 30.2 138.7 36.1 42.0 50.4 265.4 234.2 28.5 36.1 81.3 44.7 26.0 42.8 19.2 29.8 81.7 19.7 52.8 60.9 41.2 30.6 38.1 28.7 8.2 39.0 36.5 35.8 17.4 TOPORS "LUN, RP31, TP53BPL" ENSG00000197579 "TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase" Q9NS56 9 32540544-32552586 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, Ubl conjugation pathway" Transferase "Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 169.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 67.6" "Lineage enriched" "Detected in all" 4 "granulocytes: 67.6" "Cell line enhanced" "Detected in all" "HEL: 90.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA060640, HPA065661" Supported Supported Nucleoplasm NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 34: Non-specific - Transcription" "Cluster 36: HEL - Hemostasis" "Cluster 29: Early spermatids - Spermatogenesis" Nucleoplasm "HPA060640: AB_2684334, HPA065661: AB_2685527" "unprognostic (1.75e-1)" "unprognostic (1.73e-1)" "unprognostic (1.20e-2)" "unprognostic (1.14e-2)" "unprognostic (1.29e-1)" "unprognostic (1.01e-1)" "unprognostic (1.45e-1)" "unprognostic (1.37e-2)" "unprognostic (9.94e-2)" "prognostic favorable (7.07e-4)" "unprognostic (2.70e-1)" "unprognostic (3.61e-1)" "prognostic favorable (6.64e-6)" "unprognostic (1.22e-1)" "unprognostic (5.95e-2)" "unprognostic (3.13e-1)" "unprognostic (2.92e-1)" 9.8 9.8 5.4 8.4 6.3 25.2 12.4 10.5 8.5 10.3 7.3 9.2 8.3 11.4 10.0 9.9 7.6 8.7 6.8 5.4 6.6 13.2 16.2 9.3 9.3 6.1 6.1 15.3 8.6 14.0 6.9 10.0 6.2 11.2 9.3 11.5 7.6 9.3 7.2 9.6 8.8 11.2 5.9 10.5 8.9 14.8 6.6 14.5 14.1 10.4 10.1 10.3 7.2 8.3 16.6 15.1 20.4 17.9 24.4 21.8 12.9 20.7 19.5 16.9 19.5 9.5 8.3 26.8 11.7 20.8 14.8 10.9 24.2 23.5 23.6 22.5 13.3 90.8 25.2 11.9 15.1 26.1 24.0 17.9 25.8 24.4 17.1 20.9 20.8 20.1 16.1 13.6 27.9 8.9 23.5 47.6 27.2 12.3 15.2 23.9 18.1 12.2 22.5 17.2 10.1 16.1 20.7 11.2 13.8 22.9 11.3 14.7 22.0 18.4 18.6 9.6 15.5 9.5 16.2 28.5 17.0 14.8 8.4 38.8 10.0 21.3 9.6 9.8 10.3 9.4 10.4 11.4 10.2 10.8 13.9 13.8 67.6 15.0 13.6 8.2 13.5 7.3 5.4 6.3 10.5 8.5 5.4 6.6 6.1 6.1 6.2 5.9 6.6 8.3 69.2 54.5 32.0 10.7 49.1 47.2 45.3 33.7 61.5 46.8 32.7 28.6 18.4 25.8 37.0 25.8 37.5 31.9 63.4 26.3 19.6 25.1 169.9 36.2 38.1 48.8 45.9 66.5 14.5 18.4 16.9 42.0 25.0 45.5 41.8 43.6 26.4 24.3 17.7 55.5 15.5 22.9 44.7 19.1 35.3 21.8 33.2 31.8 19.6 7.5 30.4 43.5 36.0 13.0 22.4 21.1 24.3 32.7 39.5 39.0 24.3 22.7 22.3 42.0 19.7 54.0 48.2 54.4 53.7 39.0 47.6 50.8 55.4 43.1 24.0 49.8 TOR1A "DQ2, DYT1" ENSG00000136827 "Torsin family 1 member A" O14656 9 129812942-129824244 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Chaperone, Hydrolase" "Disease variant, Dystonia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB012473, HPA051195" Approved Supported "Nuclear membrane,Vesicles" "Intracellular and membrane" NA NA 20000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 55: Plasma cells - Humoral immune response" "Nuclear membrane, Vesicles" "CAB012473: AB_2240792, HPA051195: AB_2681382" "unprognostic (1.20e-1)" "unprognostic (1.92e-1)" "unprognostic (2.65e-1)" "unprognostic (1.18e-1)" "unprognostic (1.95e-1)" "unprognostic (1.86e-3)" "unprognostic (3.67e-2)" "prognostic unfavorable (5.45e-4)" "unprognostic (2.10e-2)" "unprognostic (1.41e-1)" "unprognostic (4.10e-2)" "unprognostic (2.86e-1)" "unprognostic (1.35e-1)" "unprognostic (3.39e-1)" "unprognostic (1.91e-1)" "unprognostic (1.77e-1)" "unprognostic (1.99e-1)" 21.2 24.2 14.3 20.7 14.8 34.5 19.6 14.7 17.7 18.6 14.2 20.7 16.6 20.3 19.9 14.3 17.2 20.6 16.8 15.7 15.9 20.5 35.9 19.4 22.9 13.6 14.0 17.2 19.5 19.4 14.3 23.5 14.0 21.3 22.3 9.8 17.0 23.1 16.4 17.8 18.8 25.4 14.1 18.8 18.1 9.2 15.4 26.3 23.8 14.9 19.0 28.6 15.6 14.8 33.7 49.5 35.9 41.5 53.1 51.3 47.4 76.7 94.5 67.0 57.2 32.3 48.2 41.0 44.0 99.7 46.0 77.2 34.7 50.8 54.7 65.7 32.9 36.9 49.8 32.3 66.9 82.1 65.5 69.8 50.7 63.5 45.6 61.5 73.2 65.3 66.5 32.3 74.6 84.3 58.9 79.3 53.8 39.2 55.6 30.5 56.5 41.9 54.9 42.4 27.0 47.6 79.3 30.7 43.3 40.1 61.6 63.4 65.1 66.1 37.7 49.6 59.6 36.6 87.0 37.7 49.0 46.9 54.3 95.5 72.8 141.3 57.4 68.5 48.1 45.5 48.4 52.1 61.4 33.5 40.9 42.4 72.7 68.6 58.3 56.5 59.1 78.9 14.3 14.8 14.7 17.7 15.7 15.9 13.6 14.0 14.0 14.1 15.4 14.8 25.0 9.6 11.8 5.5 17.5 17.6 16.6 39.5 12.0 11.2 16.5 15.9 9.9 18.6 24.4 14.7 2.1 47.9 39.3 18.7 15.6 42.1 0.7 12.5 18.8 24.2 19.2 30.5 6.3 49.9 65.7 25.0 13.7 15.0 22.2 23.4 16.1 22.7 45.2 21.9 6.4 17.8 26.4 19.1 22.4 1.3 12.8 27.9 14.2 3.7 47.6 18.5 35.0 9.5 6.6 40.1 18.9 15.4 23.7 24.7 21.0 17.0 14.9 9.2 32.9 15.2 24.3 7.3 10.1 9.3 18.5 53.4 25.5 23.4 15.4 19.6 TP53 "LFS1, p53" ENSG00000141510 "Tumor protein p53" P04637 17 7661779-7687538 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors, Transporters" "Apoptosis, Biological rhythms, Cell cycle, Host-virus interaction, Necrosis, Transcription, Transcription regulation" "Activator, DNA-binding, Repressor" "Cancer-related genes, Disease variant, Li-Fraumeni syndrome, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002973, CAB039238, CAB039239, HPA051244, HPA063532, CAB072876, CAB079965" Enhanced Supported Nucleoplasm,Mitochondria,Cytosol Yes No "Cluster 39: Non-specific - mRNA processing" "Cluster 3: T-cells - Adaptive immune response" "Cluster 14: REH - Unknown function" "Cluster 32: Non-specific - Translation" Nucleoplasm "Mitochondria, Cytosol" "CAB002973: AB_2206626, CAB039238: , CAB039239: , CAB072876: AB_2665731, CAB079965: , HPA051244: AB_2681403, HPA063532: " "unprognostic (2.29e-2)" "unprognostic (8.83e-3)" "unprognostic (1.26e-2)" "prognostic favorable (1.35e-4)" "unprognostic (9.95e-2)" "unprognostic (4.00e-2)" "unprognostic (2.79e-3)" "unprognostic (4.99e-2)" "unprognostic (2.75e-2)" "unprognostic (2.55e-1)" "unprognostic (1.30e-1)" "prognostic unfavorable (5.01e-4)" "unprognostic (1.86e-3)" "unprognostic (7.89e-3)" "unprognostic (8.05e-2)" "unprognostic (2.74e-1)" "unprognostic (1.08e-1)" 19.3 13.8 10.4 27.1 12.6 19.6 22.5 10.4 16.5 19.9 10.3 29.0 18.9 24.5 12.8 28.8 31.3 13.2 11.1 10.1 11.4 14.9 16.5 15.1 34.6 18.7 13.6 27.3 18.3 9.4 7.3 23.5 12.5 17.7 27.5 4.1 18.9 15.3 12.3 37.4 20.4 24.6 12.6 31.1 22.6 10.4 12.3 47.2 17.4 6.1 45.4 20.8 19.9 13.3 81.5 145.3 81.1 57.3 37.3 43.9 82.8 28.4 66.1 78.5 100.2 4.2 40.6 190.5 126.9 58.7 77.6 174.9 119.7 80.4 72.8 42.7 76.5 77.6 76.8 70.9 111.5 1.6 37.0 55.7 93.0 38.9 106.5 45.6 79.4 24.7 3.8 6.9 41.5 145.1 130.0 96.3 80.2 10.4 2.4 252.2 56.1 66.2 59.4 87.3 46.0 80.5 94.1 62.6 24.3 39.4 109.2 7.4 100.7 91.6 30.2 1.0 48.3 47.6 37.9 82.5 23.6 9.7 80.1 1.2 21.2 3.4 13.0 21.7 15.9 21.5 13.3 14.6 30.3 19.1 13.7 15.4 2.4 17.5 19.3 27.3 17.3 14.7 10.4 12.6 10.4 16.5 10.1 11.4 18.7 13.6 12.5 12.6 12.3 13.3 21.1 9.6 12.8 16.3 26.0 28.7 14.5 24.6 24.5 2.6 36.1 30.4 2.5 18.6 15.4 20.2 0.0 36.9 24.7 16.9 9.8 24.8 12.8 11.5 29.0 24.5 30.7 21.7 2.1 18.1 39.6 17.0 11.2 19.5 1.3 31.7 22.1 18.0 24.2 0.0 3.2 43.0 18.3 27.8 20.1 3.8 23.0 19.3 12.4 7.5 31.9 4.9 25.7 9.0 8.0 15.8 16.4 17.0 7.8 15.7 10.3 10.1 8.8 2.6 13.1 25.9 20.6 0.5 4.9 28.7 32.8 22.4 16.5 27.4 54.1 11.5 TPP1 "CLN2, LPIC, SCAR7, TPP-1" ENSG00000166340 "Tripeptidyl peptidase 1" O14773 11 6612768-6619448 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Disease variant, Epilepsy, Neurodegeneration, Neuronal ceroid lipofuscinosis, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hofbauer cells: 261.6;Kupffer cells: 376.5;Macrophages: 219.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037709, HPA044868" Enhanced "Intracellular and membrane" NA NA 9500000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 3: HMC-1 - Innate immune response" "Cluster 4: Macrophages - Innate immune response" "HPA037709: AB_10672913, HPA044868: AB_2679122" "unprognostic (8.27e-3)" "unprognostic (5.85e-2)" "unprognostic (7.12e-3)" "unprognostic (3.34e-3)" "unprognostic (1.56e-2)" "prognostic unfavorable (4.31e-4)" "prognostic unfavorable (1.11e-4)" "unprognostic (6.32e-2)" "unprognostic (3.01e-1)" "unprognostic (2.39e-2)" "unprognostic (1.31e-1)" "unprognostic (6.54e-2)" "unprognostic (6.23e-2)" "prognostic unfavorable (4.46e-4)" "unprognostic (3.87e-2)" "unprognostic (2.59e-1)" "unprognostic (1.12e-2)" 74.7 145.9 71.0 74.6 81.0 111.7 44.3 80.3 81.4 53.8 120.1 59.1 59.9 74.0 43.1 39.5 47.1 65.1 56.3 70.6 78.4 71.6 92.7 81.5 77.7 85.2 82.6 49.7 36.2 54.2 63.6 94.2 81.0 38.9 59.7 48.5 42.5 57.5 31.4 39.5 73.3 92.0 74.7 135.0 48.4 20.0 83.3 47.4 45.7 39.0 60.9 68.4 42.8 90.4 26.1 48.1 25.9 50.5 309.9 160.1 21.8 50.9 220.7 36.9 62.0 20.1 122.5 37.4 32.6 136.6 220.2 85.8 48.3 68.7 57.9 37.3 27.6 32.2 23.8 54.9 210.9 45.8 182.6 231.8 104.5 45.9 102.6 240.4 158.8 32.9 59.8 124.6 110.4 30.2 16.6 52.4 18.0 61.5 57.1 36.1 21.6 77.0 62.8 38.2 4.5 20.4 52.6 44.6 91.0 76.5 30.8 79.7 188.0 119.7 33.1 101.1 19.8 92.3 95.3 14.0 139.8 101.7 64.5 67.0 167.1 38.2 39.9 171.2 30.0 35.1 31.4 41.0 185.9 37.0 20.1 27.2 27.5 29.1 125.1 93.1 60.3 138.8 71.0 81.0 80.3 81.4 70.6 78.4 85.2 82.6 81.0 74.7 83.3 90.4 32.0 25.6 37.3 31.6 53.0 23.7 28.4 29.8 13.1 24.8 21.1 23.9 41.8 50.1 26.8 16.5 12.5 35.4 71.0 55.2 5.9 42.2 11.8 13.3 30.2 40.7 16.7 37.5 12.5 13.4 45.3 40.3 16.3 24.8 62.2 25.6 75.7 81.0 261.6 15.2 12.4 31.3 26.4 376.5 126.5 11.2 27.1 219.8 90.7 15.9 156.0 37.9 49.4 8.0 21.9 17.4 44.1 26.4 26.4 23.5 99.7 51.6 14.5 23.8 6.6 19.0 20.3 0.8 1.1 27.6 20.0 88.0 42.2 24.6 32.5 26.5 TPRN "C9orf75, DFNB79, FLJ90254" ENSG00000176058 Taperin Q4KMQ1 9 137191617-137204193 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Hearing "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 56.4;pancreas: 91.4" "Cell type enhanced" "Detected in all" "Distal enterocytes: 177.7;Proximal enterocytes: 95.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "MCF7: 61.9" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebellum: 23.6" "HPA020899, HPA076667" Approved Approved "Plasma membrane" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 22: Non-specific - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane" "HPA020899: AB_1845835, HPA076667: " "unprognostic (5.41e-2)" "prognostic favorable (2.13e-4)" "unprognostic (2.94e-1)" "unprognostic (9.28e-2)" "unprognostic (1.68e-1)" "unprognostic (2.61e-2)" "unprognostic (3.59e-3)" "unprognostic (8.20e-2)" "unprognostic (9.96e-2)" "unprognostic (1.21e-1)" "unprognostic (1.89e-2)" "unprognostic (4.77e-2)" "prognostic favorable (5.16e-9)" "unprognostic (1.96e-3)" "unprognostic (6.35e-2)" "unprognostic (1.51e-1)" "unprognostic (5.44e-2)" 3.7 5.1 24.3 4.4 37.8 2.7 4.8 29.9 33.1 5.2 15.1 25.4 22.0 4.7 0.9 20.5 5.1 3.2 10.7 23.5 23.7 19.1 24.3 8.1 2.4 33.1 32.4 6.4 91.4 2.5 6.0 3.3 28.2 8.0 6.9 1.7 11.8 3.4 6.2 15.6 26.0 1.5 20.8 5.0 29.3 9.3 31.9 2.0 5.5 3.1 1.5 7.8 6.9 56.4 10.2 11.4 3.8 17.0 5.2 5.5 30.1 7.0 4.3 7.0 3.9 38.5 12.1 18.6 10.1 3.6 9.2 30.4 7.9 3.9 0.9 11.9 11.1 8.7 17.5 25.5 7.9 13.5 10.8 4.7 7.5 6.2 4.3 4.6 4.5 8.2 16.1 6.4 2.1 61.9 8.9 29.0 13.5 55.5 14.8 26.3 9.1 28.4 15.9 21.0 24.4 8.9 10.8 49.6 13.0 2.9 57.8 21.0 5.0 12.7 6.0 20.1 15.1 5.3 11.0 9.7 9.1 12.1 7.2 0.0 0.8 0.0 0.3 0.8 0.1 0.3 0.3 0.5 0.6 0.3 0.1 0.3 0.0 0.8 0.4 0.6 0.6 0.2 24.3 37.8 29.9 33.1 23.5 23.7 33.1 32.4 28.2 20.8 31.9 56.4 4.6 19.2 5.5 6.2 3.5 1.8 1.3 2.6 2.2 19.3 13.2 9.5 7.6 15.7 2.6 16.5 6.2 5.4 8.4 177.7 7.9 8.0 3.1 7.6 4.1 2.9 9.0 7.4 3.3 45.4 1.3 3.0 15.3 9.6 1.3 8.7 3.9 19.5 3.6 11.8 3.8 46.0 6.1 2.8 1.6 5.3 3.4 5.2 5.4 1.0 2.8 12.4 1.0 2.5 30.4 15.3 39.7 4.5 1.9 3.3 95.9 20.0 2.3 7.3 6.6 3.2 4.5 2.7 4.4 5.8 2.8 1.9 4.5 10.3 36.7 1.7 TRAK1 "KIAA1042, MILT1, OIP106" ENSG00000182606 "Trafficking kinesin protein 1" Q9UPV9 3 42013802-42225890 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 168.9;skeletal muscle: 262.4;tongue: 202.6" "Cell type enhanced" "Detected in all" "Astrocytes: 173.0;Cardiomyocytes: 262.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "RT4: 165.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005853, HPA011367" Approved Approved "Nucleoplasm,Endoplasmic reticulum" NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 15: RT4 - Unknown function" "Cluster 46: Photoreceptor cells - Phototransduction" "Endoplasmic reticulum" Nucleoplasm "HPA005853: AB_1854778, HPA011367: AB_2668495" "unprognostic (5.55e-2)" "unprognostic (1.38e-2)" "unprognostic (5.49e-2)" "unprognostic (2.52e-2)" "unprognostic (1.26e-1)" "unprognostic (1.49e-1)" "unprognostic (1.80e-2)" "unprognostic (1.95e-1)" "unprognostic (1.39e-1)" "unprognostic (2.13e-2)" "unprognostic (3.01e-2)" "unprognostic (3.56e-3)" "prognostic favorable (4.84e-8)" "unprognostic (3.65e-2)" "unprognostic (1.70e-1)" "unprognostic (1.00e-2)" "unprognostic (4.61e-3)" 26.0 13.1 23.0 17.1 26.2 18.2 18.0 28.5 27.7 13.7 27.8 27.1 34.5 12.2 10.4 29.3 19.8 26.9 168.9 24.2 19.5 20.1 15.3 24.1 22.8 24.4 30.3 8.5 13.1 32.2 17.7 15.3 21.6 15.4 25.4 96.7 44.1 13.1 262.4 45.1 42.0 16.8 19.1 22.2 61.0 12.1 26.0 17.9 31.4 202.6 22.6 33.8 18.4 21.4 22.2 19.2 37.9 16.4 25.6 24.9 48.9 29.5 33.5 19.0 20.6 12.8 30.7 43.9 15.1 75.2 20.4 10.7 26.5 68.8 20.6 39.6 18.8 30.4 19.9 35.6 12.8 34.6 22.9 21.4 28.9 41.9 38.0 28.1 38.6 11.6 15.7 34.4 24.4 9.2 3.7 18.1 16.4 60.4 14.8 16.1 14.1 36.8 26.3 165.3 23.8 27.9 11.3 16.3 16.2 31.4 14.6 29.3 39.6 16.6 19.2 99.0 17.4 25.7 23.0 38.9 18.2 30.2 16.4 0.9 1.3 0.5 0.6 2.4 0.5 2.4 0.9 0.7 1.5 3.6 0.3 0.9 0.6 1.0 1.4 2.5 0.4 0.7 23.0 26.2 28.5 27.7 24.2 19.5 24.4 30.3 21.6 19.1 26.0 21.4 27.4 32.1 32.4 173.0 23.9 38.0 16.3 32.1 30.1 22.7 18.5 17.7 262.0 24.3 38.1 14.7 100.1 23.0 13.9 61.4 1.9 10.8 1.1 53.3 21.8 23.9 22.8 6.5 62.0 12.3 18.3 14.0 81.1 70.0 10.8 11.5 6.8 10.3 15.7 33.7 81.3 39.5 26.4 15.7 33.4 3.0 1.8 23.3 24.9 97.4 17.9 27.8 4.1 105.1 64.8 24.2 37.1 2.6 5.4 18.5 97.9 10.2 80.6 139.9 32.9 15.9 29.9 1.0 3.9 27.5 43.2 15.7 7.5 4.6 35.6 27.0 TRAPPC12 "CGI-87, TTC-15, TTC15" ENSG00000171853 "Trafficking protein particle complex 12" Q8WVT3 2 3379675-3485094 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "ER-Golgi transport, Transport" "Deafness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 96.6" "Cell type enhanced" "Detected in all" "Early spermatids: 293.9;Late spermatids: 504.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034799, HPA043196" Uncertain Supported "Nucleoplasm,Golgi apparatus" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 71: Testis - DNA repair" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 31: Spermatids - Spermatogenesis" "Nucleoplasm, Golgi apparatus" "HPA034799: AB_10600920, HPA043196: " "prognostic favorable (1.80e-5)" "unprognostic (9.21e-2)" "unprognostic (1.01e-2)" "unprognostic (1.97e-2)" "unprognostic (7.96e-2)" "unprognostic (1.32e-2)" "unprognostic (1.57e-2)" "unprognostic (1.80e-2)" "unprognostic (1.38e-1)" "unprognostic (4.27e-1)" "prognostic favorable (9.15e-4)" "unprognostic (3.23e-2)" "prognostic unfavorable (2.44e-4)" "unprognostic (1.26e-1)" "unprognostic (1.49e-1)" "unprognostic (1.53e-1)" "unprognostic (7.18e-2)" 21.7 26.0 13.9 10.9 14.4 10.1 21.8 15.0 23.3 20.2 13.5 27.9 10.1 23.7 6.3 23.0 22.2 10.4 46.7 14.8 15.9 22.6 28.0 17.1 16.0 15.9 14.1 21.4 26.2 18.4 26.7 6.6 17.1 20.6 4.7 9.1 25.8 10.0 45.8 35.7 21.2 5.2 14.6 22.1 28.4 96.6 14.8 15.7 24.7 6.4 5.0 26.1 18.9 15.5 16.4 28.0 9.1 10.4 19.9 24.5 23.9 26.6 6.5 7.6 4.2 17.5 13.6 18.8 28.6 9.0 6.7 20.8 10.5 11.9 3.1 22.8 39.5 16.2 8.1 60.8 9.0 20.4 28.0 18.1 9.0 8.5 21.2 5.8 6.7 21.5 25.5 10.0 13.5 22.5 20.6 34.9 22.1 7.3 39.4 15.4 12.4 15.3 8.1 13.5 23.2 37.8 10.6 11.8 18.5 4.0 13.9 16.3 17.2 18.6 10.6 18.7 23.6 28.5 22.4 15.0 21.8 15.9 10.5 0.7 1.0 3.8 0.8 2.5 2.0 0.5 1.3 2.2 1.4 0.5 0.8 1.0 1.0 0.9 3.6 4.3 2.5 0.8 13.9 14.4 15.0 23.3 14.8 15.9 15.9 14.1 17.1 14.6 14.8 15.5 18.8 9.6 12.8 59.4 20.7 11.5 16.2 15.1 14.2 31.8 13.7 16.0 68.4 21.5 11.2 12.9 33.3 21.3 16.9 17.1 58.7 21.7 293.9 20.3 16.4 18.5 3.5 19.1 56.2 18.0 15.2 23.7 23.0 14.5 5.7 22.3 11.0 16.0 25.9 26.9 62.5 17.7 14.2 17.9 10.0 504.5 26.4 20.7 16.0 30.0 28.5 42.6 15.5 52.3 56.4 23.9 11.9 24.0 19.6 16.0 20.3 30.0 19.4 42.0 26.3 20.9 21.7 125.2 26.3 18.8 17.8 17.6 14.4 33.8 15.7 12.2 TRAPPC2L HSPC176 ENSG00000167515 "Trafficking protein particle complex 2 like" Q9UL33 16 88856220-88862686 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "ER-Golgi transport, Transport" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 403.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041714 Approved Supported Vesicles,Cytosol NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 43: Testis - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" "Vesicles, Cytosol" "HPA041714: AB_10793930" "unprognostic (1.27e-2)" "unprognostic (2.32e-3)" "unprognostic (1.46e-1)" "prognostic favorable (3.75e-4)" "unprognostic (2.77e-1)" "unprognostic (2.69e-1)" "unprognostic (5.24e-3)" "unprognostic (2.90e-1)" "unprognostic (2.84e-1)" "unprognostic (6.53e-3)" "unprognostic (1.05e-1)" "unprognostic (2.81e-1)" "unprognostic (1.02e-2)" "unprognostic (1.18e-1)" "unprognostic (1.00e-1)" "unprognostic (5.81e-2)" "unprognostic (1.94e-2)" 55.4 134.3 55.1 30.9 56.7 36.9 51.5 57.4 69.8 49.1 55.2 46.0 25.3 46.7 60.3 53.8 44.1 19.9 66.4 57.8 61.9 53.5 46.5 42.7 31.1 57.5 57.9 55.8 48.8 58.1 45.3 20.4 59.1 39.2 23.8 25.6 48.0 20.5 96.8 58.5 39.1 18.1 60.0 52.7 62.8 122.0 56.9 50.0 41.8 70.7 27.2 48.5 47.3 65.4 69.9 47.9 79.6 60.8 58.5 73.9 81.5 61.5 69.4 92.6 35.4 133.6 89.6 53.4 105.8 78.6 97.7 73.3 109.5 88.5 67.0 46.9 65.7 35.3 46.1 172.7 86.3 101.4 27.5 72.2 54.7 125.4 63.1 52.4 75.7 118.7 108.2 41.4 64.3 216.2 136.1 311.7 80.3 133.4 88.6 128.9 65.9 55.4 73.1 79.6 85.8 42.2 207.6 63.5 59.0 43.6 162.5 106.3 60.3 61.1 66.7 81.1 71.2 57.9 106.6 254.5 73.3 148.0 74.5 39.2 136.3 40.8 113.0 114.5 115.0 154.2 129.8 124.1 135.1 137.9 120.8 103.5 23.9 94.6 114.8 162.5 178.0 162.9 55.1 56.7 57.4 69.8 57.8 61.9 57.5 57.9 59.1 60.0 56.9 65.4 66.2 57.7 82.0 2.3 58.7 51.9 57.4 115.4 43.3 34.9 80.1 106.3 121.1 92.9 81.1 53.3 10.4 93.8 58.2 75.3 240.7 134.7 219.1 60.9 53.4 60.7 62.1 42.1 4.0 154.8 141.5 79.2 72.9 50.5 36.1 55.9 62.8 123.9 226.7 15.2 5.1 78.5 75.3 91.0 69.6 403.2 74.0 68.4 81.8 1.9 134.4 87.3 79.3 2.5 13.0 137.4 76.3 58.3 92.6 45.3 122.5 271.7 93.5 39.5 59.2 44.1 94.7 210.7 123.1 86.0 64.9 77.6 61.2 64.6 86.8 62.5 TREX1 "AGS1, DRN3" ENSG00000213689 "Three prime repair exonuclease 1" Q9NSU2 3 48465811-48467645 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Exonuclease, Hydrolase, Nuclease" "Aicardi-Goutieres syndrome, Disease variant, Neurodegeneration, Systemic lupus erythematosus" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 53.6;Club cells: 24.5;Ionocytes: 40.7;Langerhans cells: 22.6;Melanocytes: 24.9;Respiratory ciliated cells: 29.9" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+ SV40 Large T+ RasG12V: 67.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035437, HPA046721" Supported Supported Cytosol NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Cytosol "HPA035437: AB_10672092, HPA046721: AB_2732531" 9.9 14.3 32.7 16.5 33.4 28.7 12.2 33.2 42.1 13.8 39.8 12.4 11.1 7.7 11.4 19.2 15.5 13.8 10.7 33.0 32.7 12.2 12.8 13.8 26.6 33.0 34.2 7.4 13.1 11.3 20.6 8.4 34.3 16.6 9.9 1.9 36.5 15.4 9.7 26.4 12.0 7.0 33.8 25.0 13.7 4.0 33.5 18.1 8.4 13.8 18.1 13.1 10.4 33.7 19.2 18.1 13.3 10.3 18.1 17.5 0.0 6.7 29.5 46.9 67.5 0.3 21.8 23.8 11.7 24.4 44.8 21.4 0.9 27.2 6.7 19.9 1.6 13.5 58.1 0.5 20.1 12.8 9.3 16.2 2.5 25.9 9.8 9.8 20.4 16.9 0.0 32.6 20.7 0.4 17.3 8.6 0.1 11.0 11.2 14.4 4.9 43.2 13.4 3.8 0.1 8.1 21.8 29.6 15.4 0.9 0.8 20.3 22.2 8.5 9.2 21.8 14.2 26.4 16.9 10.4 21.5 25.4 7.5 7.7 142.3 11.0 32.6 119.2 18.7 86.8 43.0 31.4 125.9 87.5 40.3 33.8 82.2 30.9 94.6 99.1 43.3 78.6 32.7 33.4 33.2 42.1 33.0 32.7 33.0 34.2 34.3 33.8 33.5 33.7 0.0 0.0 0.5 6.8 2.1 9.1 0.0 53.6 0.6 0.0 0.0 0.0 6.3 0.0 24.5 0.0 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.0 0.0 4.6 0.0 1.7 2.3 0.0 0.0 4.3 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 2.8 40.7 0.0 22.6 0.0 0.0 2.0 24.9 5.6 0.0 0.0 0.0 1.0 5.9 0.0 1.1 0.0 3.9 0.0 0.0 0.0 29.9 0.0 0.0 0.0 4.2 0.0 0.0 2.7 13.9 0.0 2.6 0.0 1.5 0.0 TRIM2 "CMT2R, KIAA0517, RNF86" ENSG00000109654 "Tripartite motif containing 2" Q9C040 4 153152163-153339319 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 116.2" "Cell type enriched" "Detected in many" 4 "Oligodendrocytes: 1132.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "memory CD4 T-cell: 1.0" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "AF22: 47.0;SK-MEL-30: 46.8" "HPA035853, HPA035854" Supported Uncertain Centrosome NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 45: Intestine - Brush border" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Centrosome "HPA035853: AB_10669533, HPA035854: AB_10669659" "unprognostic (8.94e-2)" "unprognostic (7.89e-2)" "unprognostic (6.21e-3)" "unprognostic (7.51e-3)" "unprognostic (2.07e-2)" "unprognostic (2.32e-1)" "unprognostic (1.16e-2)" "unprognostic (2.30e-3)" "unprognostic (5.30e-2)" "unprognostic (6.77e-2)" "unprognostic (1.93e-2)" "unprognostic (1.42e-2)" "prognostic favorable (6.58e-14)" "unprognostic (5.89e-2)" "unprognostic (1.17e-2)" "unprognostic (4.19e-2)" "unprognostic (4.13e-2)" 5.8 11.8 29.5 4.8 64.4 0.1 11.8 38.6 46.2 23.6 0.0 21.6 17.4 9.9 8.0 10.7 15.2 12.6 8.4 48.0 34.8 24.2 7.9 7.2 2.2 40.1 33.2 12.8 12.7 1.0 21.6 2.5 56.3 13.1 19.3 19.4 42.9 13.4 2.1 7.1 17.3 7.0 35.3 10.6 27.4 1.9 37.9 2.9 50.6 3.0 3.9 12.0 11.5 116.2 10.2 0.2 47.0 24.2 22.0 27.2 0.5 12.7 15.4 3.6 4.5 4.1 0.2 0.1 7.7 21.7 8.5 6.4 24.7 4.7 3.2 0.0 5.4 0.1 4.6 0.5 24.7 0.1 0.1 13.5 2.3 5.4 4.7 12.9 3.4 0.4 0.2 0.0 4.9 0.4 2.4 0.1 37.4 27.5 8.8 1.0 9.4 0.0 37.0 11.8 14.5 27.3 4.4 2.7 46.8 6.9 1.7 0.5 2.8 12.7 3.0 10.8 3.9 0.0 0.0 0.1 20.9 0.0 20.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.0 0.0 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.8 0.1 29.5 64.4 38.6 46.2 48.0 34.8 40.1 33.2 56.3 35.3 37.9 116.2 11.2 6.4 33.7 189.0 2.6 7.0 15.3 40.2 9.1 67.7 40.5 29.1 39.6 17.2 82.1 58.8 29.2 2.0 0.7 59.4 101.8 9.6 3.3 113.3 16.3 17.3 62.3 0.4 266.4 26.1 0.5 22.0 80.0 95.6 1.3 4.8 21.0 12.4 1.4 111.0 211.2 64.1 54.9 0.8 7.7 2.4 29.5 2.2 64.0 21.5 3.2 86.9 0.0 237.2 1132.8 22.5 41.4 32.7 1.5 17.8 62.9 14.7 106.0 23.4 26.3 14.7 16.2 0.4 1.3 5.0 4.0 0.7 2.8 8.7 90.8 33.7 TRIOBP "DFNB28, HRIHFB2122, KIAA1662, TAP68, Tara" ENSG00000100106 "TRIO and F-actin binding protein" Q9H2D6 22 37697048-37776556 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" Actin-binding "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003747, HPA019769" Enhanced NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 46: Fibroblasts - ECM organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 40: Granulosa cells - Unknown function" "HPA003747: AB_1858328, HPA019769: AB_1858329" "unprognostic (2.94e-1)" "prognostic favorable (4.29e-4)" "unprognostic (2.79e-1)" "unprognostic (4.57e-2)" "unprognostic (8.22e-2)" "unprognostic (7.44e-3)" "unprognostic (3.77e-2)" "unprognostic (2.50e-1)" "unprognostic (2.20e-2)" "unprognostic (5.56e-2)" "unprognostic (2.40e-1)" "unprognostic (1.99e-1)" "unprognostic (4.38e-3)" "unprognostic (1.31e-1)" "unprognostic (2.81e-1)" "unprognostic (3.20e-2)" "unprognostic (1.67e-2)" 56.3 46.5 15.4 27.3 16.6 25.7 50.8 14.7 14.9 73.1 22.1 70.6 23.9 71.8 12.8 78.5 66.1 27.8 74.6 12.8 13.2 37.2 21.6 51.6 17.4 20.0 17.2 55.7 32.7 31.1 16.9 44.2 16.5 45.3 17.0 4.8 44.3 33.3 24.3 32.0 38.0 31.0 16.6 53.1 53.6 26.1 16.9 16.7 48.2 14.3 12.5 66.5 65.7 17.3 65.9 53.1 33.2 26.4 73.1 118.1 47.5 113.0 111.9 57.7 42.1 11.8 44.8 24.5 30.4 69.6 31.6 52.7 9.2 63.7 18.1 39.6 29.1 6.8 41.6 22.4 75.5 32.1 28.9 47.1 29.8 52.0 24.5 125.3 71.9 20.6 6.4 34.6 45.5 39.3 14.4 23.1 20.2 65.4 63.2 25.1 23.9 17.2 41.0 52.8 16.2 25.4 50.9 46.5 59.7 32.8 25.4 23.0 151.9 87.2 38.6 60.6 27.0 30.4 9.1 15.4 82.7 13.0 104.3 7.7 7.6 12.2 1.8 7.5 0.6 1.3 1.5 1.8 4.1 2.4 1.2 1.8 18.2 1.9 12.5 1.9 2.5 2.0 15.4 16.6 14.7 14.9 12.8 13.2 20.0 17.2 16.5 16.6 16.9 17.3 102.0 19.2 29.7 17.9 10.7 6.2 48.3 18.3 18.8 22.8 40.1 45.1 65.2 62.9 23.3 58.8 2.1 105.7 14.7 63.8 15.6 42.7 30.3 32.6 107.0 91.6 22.9 28.2 4.7 51.6 34.2 65.5 58.1 34.2 6.3 128.1 124.6 17.1 42.7 16.8 4.6 52.1 6.1 56.0 7.5 10.6 113.1 31.2 14.2 27.2 32.0 29.6 8.2 7.5 14.0 62.8 46.9 92.2 9.5 41.9 24.8 15.8 23.9 7.3 52.6 17.7 31.8 49.8 23.4 57.2 6.1 116.0 12.7 22.5 40.6 57.9 TRPC3 ENSG00000138741 "Transient receptor potential cation channel subfamily C member 3" Q13507 4 121874481-121952060 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel" "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 10.4;pituitary gland: 7.4" "Cell type enhanced" "Detected in some" "Excitatory neurons: 18.1;Inhibitory neurons: 82.7;Oligodendrocyte precursor cells: 33.7;Rod photoreceptor cells: 32.0" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HEL: 2.3;Karpas-707: 2.6;U-2 OS: 1.5;U-251 MG: 1.5" "Region enhanced" "Detected in all" "cerebellum: 57.8" "Low region specificity" "Detected in many" NA NA "Cluster 42: Non-specific - Transcription" "Cluster 77: Retina - Visual perception" "Cluster 2: Karpas-707 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (1.08e-1)" "unprognostic (1.19e-1)" "unprognostic (2.39e-1)" "unprognostic (3.12e-2)" "unprognostic (5.57e-2)" "unprognostic (1.93e-2)" "unprognostic (7.12e-3)" "unprognostic (9.80e-2)" "unprognostic (4.80e-3)" "unprognostic (2.38e-1)" "unprognostic (3.26e-1)" "unprognostic (1.06e-1)" "unprognostic (4.33e-3)" "unprognostic (2.67e-3)" "unprognostic (1.39e-1)" "unprognostic (2.23e-1)" "unprognostic (8.42e-3)" 0.3 0.0 2.3 0.1 4.0 0.0 0.2 4.6 5.8 0.8 0.1 0.2 0.1 0.4 0.2 0.0 0.5 0.8 0.2 0.8 3.2 0.1 0.1 0.9 0.1 10.4 2.8 0.1 0.0 0.2 7.4 1.1 2.2 0.2 0.1 3.9 0.1 0.6 0.4 0.1 0.5 2.6 1.6 0.2 0.2 0.4 4.6 0.0 0.1 0.2 0.0 1.7 0.7 1.7 0.0 0.0 0.8 0.1 0.1 0.1 0.0 0.4 0.4 0.7 0.2 0.0 0.0 0.0 0.0 0.5 0.3 0.1 0.4 0.0 0.1 0.0 1.3 2.3 0.2 0.0 0.1 0.7 0.3 0.2 0.0 0.0 0.0 1.1 0.0 0.1 0.0 2.6 0.5 0.1 0.8 0.0 0.4 0.0 0.2 0.0 0.2 0.0 0.0 0.0 1.1 0.1 0.2 0.1 0.0 0.1 0.0 0.0 0.1 1.2 1.5 0.1 1.5 0.1 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 2.3 4.0 4.6 5.8 0.8 3.2 10.4 2.8 2.2 1.6 4.6 1.7 0.5 0.0 0.0 6.5 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.8 0.0 0.0 0.0 8.4 0.0 0.5 0.0 0.0 0.0 2.3 0.0 0.3 0.2 0.0 0.0 18.1 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 82.7 0.0 0.0 0.0 0.3 0.4 0.3 0.0 0.0 0.0 0.1 4.6 0.0 33.7 1.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 32.0 0.0 0.3 1.4 0.5 0.8 0.0 0.0 0.0 0.5 0.5 0.0 0.1 TRPM1 "CSNB1C, LTRPC1, MLSN1" ENSG00000134160 "Transient receptor potential cation channel subfamily M member 1" Q7Z4N2 15 31001061-31161273 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Sensory transduction, Transport, Vision" "Ion channel, Ligand-gated ion channel, Receptor" "Congenital stationary night blindness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "retina: 9.4;skin 1: 4.1" "Group enriched" "Detected in some" 7 "Bipolar cells: 627.4;Melanocytes: 158.3" "Cancer enriched" "Detected in single" 179 "melanoma: 14.6" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 112 "SK-MEL-30: 12.1" "Not detected" "Not detected" "Not detected" "Not detected" "HPA014779, HPA071139" Enhanced Uncertain "Golgi apparatus,Plasma membrane,Centriolar satellite" NA NA "Cluster 77: Retina - Visual perception" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 56: Bipolar cells - Visual perception" "Centriolar satellite" "Golgi apparatus, Plasma membrane" "HPA014779: AB_2669090, HPA071139: " "unprognostic (5.28e-2)" "unprognostic (1.35e-1)" "unprognostic (9.89e-2)" "unprognostic (3.07e-1)" "unprognostic (1.97e-1)" "unprognostic (1.70e-1)" "unprognostic (1.29e-3)" "unprognostic (2.83e-1)" "unprognostic (2.89e-2)" "unprognostic (1.67e-1)" "unprognostic (1.45e-2)" "unprognostic (2.58e-1)" "unprognostic (7.84e-2)" "unprognostic (6.20e-4)" "unprognostic (1.48e-1)" "unprognostic (2.63e-2)" 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.3 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 9.4 0.1 0.0 0.0 4.1 0.0 0.0 0.5 0.0 0.0 1.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.3 0.3 0.1 0.2 0.2 0.4 0.3 0.5 0.3 0.5 0.0 0.0 0.0 0.7 0.0 4.2 0.0 0.0 0.0 627.4 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 50.5 0.1 0.1 1.7 0.0 0.0 0.9 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.1 13.5 0.8 0.0 0.0 0.0 1.0 6.3 0.0 0.0 158.3 0.0 0.0 11.0 0.0 0.0 19.4 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 22.2 0.0 0.1 0.1 10.1 4.4 1.8 1.0 1.0 0.0 0.0 0.0 0.1 TRPM7 "CHAK1, LTRPC7, TRP-PLIK" ENSG00000092439 "Transient receptor potential cation channel subfamily M member 7" Q96QT4 15 50552473-50686797 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Necrosis, Transport" "Calcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase" "Amyotrophic lateral sclerosis, Neurodegeneration, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 108.9" "Cell type enhanced" "Detected in all" "Excitatory neurons: 122.2;Oligodendrocytes: 109.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-2197: 122.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035522, HPA052173" Enhanced Approved "Vesicles,Plasma membrane,Cytosol" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 18: U-2197 - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" "Vesicles, Cytosol" "HPA035522: , HPA052173: AB_2681749" "unprognostic (3.14e-2)" "unprognostic (1.86e-1)" "unprognostic (1.58e-1)" "unprognostic (1.42e-2)" "unprognostic (1.89e-1)" "unprognostic (1.60e-2)" "unprognostic (1.85e-2)" "unprognostic (2.59e-2)" "unprognostic (5.46e-3)" "unprognostic (2.64e-1)" "unprognostic (2.91e-1)" "unprognostic (1.59e-2)" "unprognostic (3.20e-2)" "unprognostic (2.08e-1)" "unprognostic (7.59e-2)" "unprognostic (9.45e-2)" "unprognostic (1.97e-1)" 11.5 9.6 4.3 13.3 6.5 21.4 13.6 15.4 6.7 10.3 29.3 13.8 14.4 12.7 14.6 8.6 9.4 11.1 15.5 4.8 3.5 22.9 25.3 11.6 16.6 4.9 3.9 16.4 12.2 108.9 5.3 13.3 5.9 10.9 14.4 10.5 10.9 10.6 7.8 16.6 13.1 11.4 3.2 12.2 13.6 9.9 6.4 15.5 17.3 9.1 14.4 11.4 8.1 10.4 21.4 21.0 17.2 19.1 48.5 36.2 20.9 26.4 36.7 16.5 21.6 29.1 11.6 46.4 12.7 30.8 42.5 35.1 23.3 19.5 23.4 26.0 13.7 37.1 31.5 15.4 44.0 38.8 27.6 33.9 22.4 18.8 35.0 24.0 13.5 28.8 42.6 34.5 30.4 33.7 25.1 18.8 13.0 29.4 12.8 27.2 23.7 22.7 23.0 49.9 14.2 18.1 18.2 28.7 35.8 30.1 18.0 41.6 20.7 26.1 12.4 122.4 30.8 23.3 54.9 44.0 28.4 77.5 24.8 1.8 1.3 1.6 2.5 1.3 2.9 2.2 1.8 1.7 1.5 2.3 1.6 1.9 1.7 2.4 1.4 1.9 2.0 0.8 4.3 6.5 15.4 6.7 4.8 3.5 4.9 3.9 5.9 3.2 6.4 10.4 23.9 19.2 31.3 73.1 36.4 31.6 17.2 11.0 44.9 21.9 18.8 11.9 25.9 21.5 8.2 12.9 12.5 23.0 38.4 17.0 3.9 11.7 33.3 21.6 27.1 19.7 18.5 29.6 122.2 12.7 9.4 26.1 37.8 23.1 17.7 26.0 14.6 43.9 14.6 21.9 92.7 19.5 6.1 22.4 19.8 26.0 26.4 26.5 19.6 66.5 24.2 8.5 29.9 80.9 109.1 15.5 13.9 20.3 33.2 24.9 23.4 11.0 19.3 22.6 13.1 30.0 22.0 23.1 23.6 25.7 24.2 16.3 34.5 22.2 20.4 11.1 TRPV4 "CMT2C, OTRPC4, TRP12, VR-OAC, VRL-2, VROAC" ENSG00000111199 "Transient receptor potential cation channel subfamily V member 4" Q9HBA0 12 109783087-109833406 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Calmodulin-binding, Ion channel" "Charcot-Marie-Tooth disease, Disease variant, Dwarfism, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 50.8;salivary gland: 19.2" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 17.1;Cholangiocytes: 20.0;Cytotrophoblasts: 20.0;Kupffer cells: 19.6;Respiratory ciliated cells: 28.2;Syncytiotrophoblasts: 21.1" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in single" 5 "hippocampal formation: 4.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 7.9;BJ hTERT+: 9.5;EFO-21: 7.2;HaCaT: 14.2;HUVEC TERT2: 8.7" "Low region specificity" "Detected in many" "Not detected" "Not detected" HPA007150 Uncertain NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "HPA007150: AB_1080393" "unprognostic (2.98e-2)" "unprognostic (1.12e-2)" "unprognostic (2.33e-2)" "unprognostic (4.20e-3)" "unprognostic (6.25e-3)" "unprognostic (1.09e-2)" "unprognostic (7.95e-2)" "unprognostic (2.03e-1)" "unprognostic (9.02e-2)" "prognostic unfavorable (8.10e-4)" "unprognostic (1.24e-1)" "unprognostic (1.68e-1)" "prognostic favorable (4.12e-5)" "unprognostic (1.20e-1)" "unprognostic (2.30e-1)" "unprognostic (1.72e-1)" "unprognostic (1.73e-2)" 1.0 0.8 0.2 0.9 0.3 0.1 1.9 0.7 0.5 2.0 50.8 0.4 0.7 0.6 0.4 10.3 4.7 1.4 0.8 4.2 0.2 14.7 8.6 2.2 0.8 0.5 0.4 0.3 4.4 0.3 2.1 5.2 0.3 6.8 0.3 0.0 19.2 0.8 0.1 7.5 0.4 0.7 0.2 2.8 0.7 0.8 0.8 0.1 0.9 0.0 0.9 1.8 2.2 0.4 2.4 0.2 0.0 0.0 2.0 1.2 7.9 4.2 9.5 1.2 0.3 0.0 6.4 0.0 7.2 5.8 0.0 14.2 1.0 0.0 0.4 0.0 1.8 0.0 0.1 3.7 0.6 0.0 0.0 3.4 2.0 2.7 0.0 0.6 8.7 0.0 0.5 0.0 0.4 5.3 0.0 0.0 1.5 0.0 0.0 0.0 0.5 0.0 0.0 4.9 0.0 0.0 0.3 0.6 2.6 3.5 1.1 0.2 4.5 0.0 2.6 0.1 0.0 0.0 0.1 0.0 0.0 0.0 5.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.7 0.5 4.2 0.2 0.5 0.4 0.3 0.2 0.8 0.4 0.1 0.0 0.0 0.0 0.7 3.3 8.1 17.1 7.4 0.0 5.1 5.5 1.0 20.0 12.0 11.0 0.0 20.0 0.4 0.0 3.9 2.5 0.2 3.2 1.0 1.4 0.0 0.0 0.3 9.3 5.3 1.2 2.0 1.2 0.0 0.9 0.7 7.7 4.0 0.0 0.4 0.0 6.1 19.6 0.7 0.2 0.9 2.6 7.2 1.9 0.8 0.0 0.0 1.0 0.3 2.0 0.0 0.0 0.0 4.6 0.0 12.5 28.2 0.0 0.0 0.1 1.1 0.3 1.1 4.5 3.8 21.1 0.3 0.2 0.0 3.3 TRRAP "PAF400, TR-AP, Tra1" ENSG00000196367 "Transformation/transcription domain associated protein" Q9Y4A5 7 98877933-99050831 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, Chromatin regulator" "Autism spectrum disorder, Cancer-related genes, Deafness, Disease variant, Mental retardation, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054376 Supported "Nucleoplasm,Golgi apparatus" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 34: Non-specific - Transcription" "Cluster 2: Karpas-707 - Immune response" "Cluster 44: Endometrium - Transcription" Nucleoplasm "Golgi apparatus" "HPA054376: AB_2682467" "unprognostic (2.10e-1)" "unprognostic (7.79e-2)" "unprognostic (2.21e-1)" "unprognostic (4.35e-2)" "unprognostic (2.02e-1)" "unprognostic (2.02e-1)" "prognostic unfavorable (8.77e-4)" "unprognostic (1.40e-2)" "unprognostic (2.39e-2)" "unprognostic (3.99e-2)" "unprognostic (9.45e-2)" "unprognostic (7.02e-2)" "unprognostic (2.21e-3)" "unprognostic (1.59e-1)" "unprognostic (1.98e-1)" "unprognostic (1.04e-1)" "unprognostic (2.96e-1)" 6.0 8.1 3.4 7.4 3.5 11.1 6.2 10.3 3.7 8.3 5.9 7.7 5.3 8.6 3.5 6.8 8.4 4.9 6.8 3.1 2.6 6.2 6.7 7.0 9.3 1.4 2.2 10.9 8.3 10.3 14.0 6.1 1.9 7.1 5.0 7.5 7.1 5.2 7.6 11.2 8.4 6.2 0.6 8.5 7.1 11.0 2.8 15.8 8.8 7.3 8.7 7.3 7.0 5.0 24.0 27.2 27.7 23.4 12.9 13.8 13.7 10.3 13.6 15.8 15.1 21.2 10.3 32.8 15.9 19.1 30.3 12.2 29.1 14.0 17.7 19.2 28.3 20.2 20.3 11.7 9.4 36.9 14.3 12.6 8.0 25.8 21.7 10.9 20.5 29.2 35.4 59.8 14.8 44.0 45.0 13.5 21.1 14.1 16.6 32.7 16.0 25.2 7.7 26.6 21.6 27.1 26.1 16.6 8.4 22.7 8.5 15.7 22.0 21.1 30.6 28.3 24.2 24.7 30.2 47.8 14.9 18.3 21.3 2.8 0.3 0.2 0.5 0.2 0.9 0.6 0.8 0.4 0.3 0.8 0.6 0.6 1.0 0.5 0.3 1.0 0.7 0.1 3.4 3.5 10.3 3.7 3.1 2.6 1.4 2.2 1.9 0.6 2.8 5.0 12.8 16.0 14.2 30.3 16.4 15.8 4.2 8.2 13.1 15.2 13.7 10.0 10.9 5.7 9.4 14.7 27.1 8.9 15.0 7.9 0.0 7.7 3.6 16.6 20.1 11.1 12.6 12.4 43.7 6.5 5.2 11.1 11.2 24.1 5.7 26.5 8.6 11.0 8.0 21.9 45.5 10.4 8.2 10.4 7.4 5.4 8.7 12.3 8.8 29.0 9.8 6.1 6.2 36.7 42.4 8.3 5.8 8.6 25.3 7.6 6.2 5.2 8.3 9.2 0.0 12.8 12.4 14.8 8.4 18.5 21.3 10.9 17.1 12.1 10.1 7.5 TSC1 "hamartin, KIAA0243, LAM, TSC" ENSG00000165699 "TSC complex subunit 1" Q92574 9 132891348-132946874 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" Chaperone "Cancer-related genes, Disease variant, Epilepsy, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 133.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011568, CAB012481, HPA074132" Supported Enhanced Cytosol NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" Cytosol "CAB011568: AB_732752, CAB012481: , HPA074132: AB_2686666" "unprognostic (1.88e-1)" "unprognostic (1.51e-1)" "unprognostic (1.40e-2)" "unprognostic (2.56e-1)" "unprognostic (6.67e-2)" "unprognostic (4.23e-3)" "prognostic unfavorable (6.03e-6)" "unprognostic (1.96e-2)" "unprognostic (3.48e-2)" "unprognostic (1.24e-1)" "prognostic favorable (8.01e-4)" "unprognostic (1.84e-2)" "prognostic favorable (7.91e-4)" "unprognostic (9.49e-2)" "unprognostic (1.46e-1)" "unprognostic (2.35e-1)" "unprognostic (1.16e-1)" 11.8 14.5 6.1 5.2 6.0 9.0 12.2 8.3 6.8 13.7 3.6 13.4 5.1 12.0 6.5 10.1 11.8 5.4 14.0 6.0 5.1 13.1 10.9 11.4 6.3 4.5 5.2 18.2 12.8 7.4 16.2 9.3 4.9 13.1 7.1 8.3 11.4 5.4 14.9 15.8 12.6 7.9 1.1 14.9 12.2 22.8 4.5 6.7 17.3 14.6 8.6 11.4 12.7 4.4 8.3 9.7 13.0 10.7 13.0 12.2 24.2 10.3 17.6 11.5 11.0 16.5 9.5 19.4 4.7 20.9 17.0 21.0 15.4 11.0 11.3 9.4 8.2 6.1 19.9 13.6 15.6 9.4 8.0 13.6 8.2 14.3 17.4 11.1 13.0 16.9 11.1 10.2 12.9 15.4 8.3 7.8 17.8 12.1 7.8 9.9 24.5 11.0 5.0 10.7 6.4 10.0 12.7 7.9 6.2 15.2 14.4 5.5 13.8 18.1 10.8 11.4 7.7 5.7 13.8 18.5 10.3 5.2 8.2 2.1 2.3 2.8 3.2 3.8 3.5 0.9 1.7 2.9 1.7 1.2 2.9 2.6 0.9 3.0 1.8 0.9 3.1 1.5 6.1 6.0 8.3 6.8 6.0 5.1 4.5 5.2 4.9 1.1 4.5 4.4 14.7 22.4 27.2 35.3 10.8 7.5 6.2 5.1 9.6 26.6 11.2 9.5 29.2 7.2 10.3 11.0 37.5 15.1 13.5 7.1 13.7 11.7 45.9 18.0 22.2 12.7 16.8 15.8 53.6 7.2 24.0 14.0 14.3 25.8 8.8 27.4 9.7 5.9 9.2 25.2 59.0 10.0 10.2 7.7 7.9 133.1 15.5 12.8 12.4 19.7 10.8 9.7 7.2 30.7 47.8 12.5 7.9 11.3 12.4 9.0 8.9 7.3 16.2 24.4 19.7 19.5 15.4 22.4 20.0 11.8 8.7 21.1 11.9 23.2 10.6 11.0 TSC2 "LAM, PPP1R160, TSC4, tuberin" ENSG00000103197 "TSC complex subunit 2" P49815 16 2047967-2089491 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Host-virus interaction" "GTPase activation" "Cancer-related genes, Disease variant, Epilepsy, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002225, HPA030409, HPA049679" Approved Enhanced Cytosol NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 52: Non-specific - Transcription" Cytosol "CAB002225: AB_564043, HPA030409: AB_10602483, HPA049679: AB_2680848" "unprognostic (2.80e-1)" "unprognostic (1.01e-1)" "unprognostic (1.60e-2)" "unprognostic (2.24e-1)" "unprognostic (1.02e-1)" "unprognostic (1.03e-3)" "unprognostic (2.04e-2)" "unprognostic (6.05e-3)" "unprognostic (3.43e-1)" "unprognostic (8.94e-2)" "prognostic favorable (5.06e-4)" "unprognostic (4.32e-2)" "unprognostic (3.91e-2)" "unprognostic (2.14e-2)" "unprognostic (2.54e-1)" "unprognostic (1.51e-2)" "unprognostic (8.96e-2)" 12.6 10.0 3.8 10.2 4.6 10.9 12.6 4.5 6.1 16.7 0.9 15.3 12.4 17.4 7.3 12.0 16.0 10.9 12.6 5.9 1.3 9.6 9.0 12.0 7.7 3.1 1.5 18.4 14.8 14.7 16.5 9.2 2.7 12.4 9.1 17.7 21.3 15.6 31.1 14.4 12.8 11.4 0.1 11.4 15.7 16.2 2.6 11.7 18.6 14.5 7.8 14.0 12.8 12.5 13.5 21.4 28.9 32.5 33.7 28.1 24.3 31.7 21.7 23.4 19.7 25.7 25.4 20.5 27.6 26.2 11.0 22.0 17.5 23.1 17.3 15.5 28.5 19.2 39.6 10.7 23.0 24.0 22.4 33.5 14.3 18.9 13.9 27.9 22.3 14.4 19.0 17.7 21.0 27.0 28.9 7.1 29.8 10.1 21.2 45.3 31.6 25.7 9.4 12.1 22.1 41.3 45.2 29.4 15.3 28.2 26.8 17.5 35.5 24.5 16.5 22.0 16.5 39.0 42.7 40.8 10.2 9.7 29.6 3.2 2.7 2.8 3.1 2.1 2.8 1.8 1.9 1.7 2.5 1.8 1.3 2.1 3.5 1.6 1.7 0.6 1.4 2.2 3.8 4.6 4.5 6.1 5.9 1.3 3.1 1.5 2.7 0.1 2.6 12.5 23.8 25.6 18.9 43.8 16.8 9.2 8.1 10.1 14.8 53.8 23.7 20.2 41.8 21.5 15.3 20.2 93.8 13.0 17.3 34.5 3.9 15.2 13.1 47.8 26.3 25.6 32.5 17.4 22.8 14.1 8.0 19.7 44.9 62.1 8.8 49.0 32.2 38.7 11.4 45.4 22.4 26.6 8.2 17.6 9.9 29.3 28.3 13.8 8.8 15.9 12.1 19.0 36.0 18.6 25.7 21.4 17.5 25.9 14.4 9.4 25.4 8.9 17.8 64.7 13.1 17.2 20.4 18.3 37.7 12.9 9.8 9.3 18.8 31.6 28.9 10.6 TSPAN12 "NET-2, TM4SF12" ENSG00000106025 "Tetraspanin 12" O95859 7 120787320-120858402 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" Angiogenesis "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 91.6" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 118.6;Collecting duct cells: 103.0;Distal tubular cells: 189.8;Glandular and luminal cells: 87.5;Proximal tubular cells: 111.1" "Cancer enhanced" "Detected in all" "renal cancer: 44.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HEK 293: 53.0;HUVEC TERT2: 58.3;RH-30: 52.2;RPTEC TERT1: 90.5;RT4: 65.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA051570, HPA058244" Uncertain Approved Vesicles,Microtubules NA NA "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 44: Endometrium - Transcription" Microtubules Vesicles "HPA051570: , HPA058244: AB_2683652" "unprognostic (2.40e-2)" "unprognostic (7.60e-2)" "unprognostic (3.66e-3)" "unprognostic (1.82e-2)" "unprognostic (3.97e-1)" "unprognostic (7.34e-3)" "unprognostic (1.60e-1)" "unprognostic (8.12e-2)" "unprognostic (1.23e-1)" "unprognostic (2.73e-1)" "unprognostic (1.63e-2)" "unprognostic (1.05e-1)" "unprognostic (9.53e-2)" "unprognostic (7.07e-2)" "unprognostic (1.51e-1)" "unprognostic (5.18e-2)" "unprognostic (1.43e-1)" 11.9 65.9 4.1 5.3 4.4 0.4 8.7 5.2 5.2 21.4 2.8 24.0 39.4 10.5 14.9 5.0 10.9 20.4 47.7 3.3 4.7 91.6 35.8 45.8 4.5 8.0 6.2 1.7 17.4 10.7 7.5 20.3 5.2 6.8 20.4 1.8 46.8 22.4 3.3 1.6 42.0 11.9 4.6 28.2 22.1 3.9 8.1 2.7 23.4 5.5 4.3 17.5 4.0 3.6 0.0 1.4 15.1 0.2 3.1 1.0 14.7 0.3 0.6 1.2 5.0 2.5 4.0 0.0 10.4 0.4 1.8 0.2 7.7 1.6 1.9 0.0 53.0 2.8 14.5 2.2 8.1 0.1 2.5 0.3 0.0 0.4 0.3 2.1 58.3 0.0 0.7 1.8 6.8 2.0 0.2 0.4 24.5 11.1 9.4 0.1 52.2 2.0 90.5 65.4 12.5 7.4 0.7 1.3 0.0 20.0 8.0 1.9 2.5 12.3 3.8 0.1 6.5 15.8 0.0 0.2 1.7 0.0 5.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.1 4.4 5.2 5.2 3.3 4.7 8.0 6.2 5.2 4.6 8.1 3.6 40.0 118.6 45.0 18.6 1.7 2.5 20.3 1.8 14.8 0.0 19.4 3.8 62.5 64.3 19.9 103.0 0.0 40.5 0.0 18.0 189.8 6.8 0.6 63.4 9.0 38.0 9.6 2.7 1.8 7.2 53.5 10.0 14.8 87.5 2.5 1.8 18.2 32.9 4.1 0.0 2.9 16.9 6.1 0.8 3.6 1.5 4.1 1.5 5.4 3.7 0.0 0.5 0.0 10.1 0.4 4.7 30.5 0.7 2.2 9.1 68.3 111.1 5.7 0.1 0.0 11.6 16.6 0.6 8.9 13.8 2.0 24.2 1.9 9.6 35.5 28.3 TSPEAR "C21orf29, DFNB98, MGC11251, TSP-EAR" ENSG00000175894 "Thrombospondin type laminin G domain and EAR repeats" Q8WU66 21 44497893-44711572 "Disease related genes, Human disease related genes, Predicted secreted proteins" Hearing "Deafness, Disease variant, Ectodermal dysplasia, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "skin 1: 1.0;testis: 1.0" "Cell type enhanced" "Detected in some" "Astrocytes: 1.3;Early spermatids: 3.3;Excitatory neurons: 1.1;Oligodendrocytes: 1.0" "Low cancer specificity" "Detected in single" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "SH-SY5Y: 1.7;U-2 OS: 1.2" "Not detected" "Not detected" "Region enhanced" "Detected in single" "olfactory bulb: 1.0" "CAB034203, CAB034204, HPA052995" Uncertain "Secreted in other tissues" NA NA "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 29: Early spermatids - Spermatogenesis" "CAB034203: AB_1567654, CAB034204: AB_1567655, HPA052995: AB_2682008" "unprognostic (8.61e-3)" "unprognostic (2.45e-1)" "unprognostic (1.86e-4)" "unprognostic (7.87e-3)" "unprognostic (4.08e-2)" "unprognostic (1.00e-3)" "unprognostic (7.92e-3)" "unprognostic (1.56e-1)" "unprognostic (1.34e-1)" "unprognostic (1.15e-2)" "unprognostic (3.86e-4)" "unprognostic (2.13e-2)" "unprognostic (4.80e-7)" "unprognostic (2.08e-1)" "unprognostic (1.69e-1)" "unprognostic (1.88e-2)" "unprognostic (2.98e-2)" 0.1 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.1 0.1 0.8 0.0 0.1 0.0 0.1 0.0 0.2 0.0 0.5 0.0 0.1 0.0 0.0 0.1 0.2 0.2 0.1 0.0 0.0 0.2 0.9 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 1.0 0.1 0.0 0.0 0.1 0.0 1.0 0.1 0.1 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.3 0.0 0.0 0.3 1.7 0.0 0.0 0.0 0.1 0.0 0.1 0.5 0.0 1.2 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.1 0.2 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 1.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.3 0.0 0.0 0.0 0.1 0.0 TSPYL1 TSPYL ENSG00000189241 "TSPY like 1" Q9H0U9 6 116267760-116279930 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031970 Supported Supported Nucleoplasm,Nucleoli No No "Cluster 38: Basophils - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nucleoplasm, Nucleoli" "HPA031970: AB_2674092" "unprognostic (1.05e-2)" "unprognostic (1.09e-1)" "unprognostic (6.11e-2)" "unprognostic (9.99e-2)" "unprognostic (1.70e-1)" "unprognostic (3.54e-2)" "unprognostic (2.46e-1)" "unprognostic (1.04e-1)" "unprognostic (2.76e-1)" "unprognostic (9.18e-3)" "prognostic favorable (5.40e-4)" "unprognostic (5.12e-1)" "prognostic favorable (1.48e-13)" "unprognostic (1.61e-1)" "unprognostic (1.81e-1)" "unprognostic (2.34e-2)" "unprognostic (2.47e-1)" 26.5 73.8 51.1 17.1 56.4 34.4 23.4 35.2 78.2 22.5 25.5 30.8 24.4 28.4 33.0 34.0 31.4 20.5 43.3 64.9 38.1 50.4 40.9 21.4 21.4 25.9 22.2 34.9 33.3 63.9 40.1 16.0 26.0 42.0 17.7 26.1 30.2 33.9 114.9 29.4 30.0 24.3 17.1 29.5 35.5 28.9 34.6 22.3 39.6 91.9 25.6 31.4 22.7 44.5 22.2 21.5 27.3 50.3 47.2 30.9 22.7 35.2 34.7 31.3 35.8 27.7 15.9 47.3 43.0 40.8 28.2 38.5 21.6 59.8 33.2 19.4 56.0 19.1 29.9 50.8 29.8 31.9 11.2 36.2 46.0 32.5 31.2 32.9 30.3 20.7 34.3 36.1 44.2 48.9 21.5 18.9 13.6 21.3 19.8 19.1 23.5 26.3 54.9 42.9 23.7 23.6 29.2 38.8 18.0 30.6 51.0 39.1 37.3 21.2 18.7 17.2 38.7 19.8 22.7 25.2 35.1 20.3 14.1 121.0 30.1 51.5 40.5 51.0 61.4 46.4 52.4 45.4 26.1 52.2 51.1 50.0 24.1 33.2 57.7 44.9 44.8 34.0 51.1 56.4 35.2 78.2 64.9 38.1 25.9 22.2 26.0 17.1 34.6 44.5 29.4 35.3 45.9 15.7 65.2 166.1 100.6 37.6 70.6 81.0 91.7 47.5 100.0 61.5 40.5 104.8 27.1 54.8 54.2 49.3 154.6 40.8 33.0 40.5 42.0 40.4 74.6 49.7 65.4 43.9 25.5 63.1 41.3 34.9 31.7 67.5 73.9 81.3 42.4 38.7 50.5 59.3 46.8 82.1 116.0 20.2 75.5 40.2 87.2 22.5 38.3 82.6 42.2 15.6 20.2 48.8 52.5 95.5 24.1 77.0 60.3 218.9 41.4 58.1 131.5 87.6 63.5 61.9 39.8 55.5 162.0 59.7 69.1 101.3 70.2 75.8 TTBK2 "KIAA0847, SCA11" ENSG00000128881 "Tau tubulin kinase 2" Q6IQ55 15 42738730-42920809 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Cilium biogenesis/degradation" "Kinase, Serine/threonine-protein kinase, Transferase" "Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 33.4" "Cell type enhanced" "Detected in many" "Excitatory neurons: 153.8;Inhibitory neurons: 185.1;Late spermatids: 146.2;Oligodendrocytes: 125.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018113, HPA049866" Approved Uncertain "Intermediate filaments" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 21: Non-specific - Transcription" "Cluster 44: HDLM-2 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Intermediate filaments" "HPA018113: AB_1858421, HPA049866: AB_2680923" "unprognostic (2.15e-1)" "unprognostic (1.67e-1)" "unprognostic (1.08e-1)" "unprognostic (6.30e-2)" "unprognostic (7.73e-2)" "unprognostic (4.26e-1)" "unprognostic (6.64e-2)" "unprognostic (5.11e-2)" "unprognostic (1.32e-1)" "unprognostic (2.43e-2)" "unprognostic (2.78e-2)" "unprognostic (8.62e-2)" "unprognostic (3.46e-2)" "unprognostic (7.29e-2)" "unprognostic (3.63e-2)" "unprognostic (2.18e-1)" "unprognostic (1.38e-1)" 5.3 4.2 7.7 3.0 9.9 5.2 4.4 11.3 20.0 6.0 2.1 6.7 1.6 5.3 3.9 2.6 5.5 3.7 7.2 6.9 13.9 3.4 3.1 4.8 3.4 17.4 9.1 6.4 2.5 4.6 5.6 4.0 18.9 4.7 3.0 17.7 3.2 3.8 10.4 3.1 3.9 5.0 6.3 4.3 3.4 33.4 16.9 5.2 3.8 6.3 3.1 5.3 4.7 13.8 5.7 3.8 8.4 4.2 6.5 6.6 1.8 4.6 7.4 4.5 6.9 4.3 1.3 3.3 6.1 4.7 9.2 3.9 8.1 6.7 6.8 13.0 3.6 4.8 6.9 1.6 5.0 6.7 7.8 4.7 6.5 3.9 21.1 9.9 5.2 5.1 7.0 4.9 4.5 0.9 4.1 4.3 2.3 1.7 3.8 7.2 9.1 1.7 5.8 4.0 6.6 6.5 12.6 0.9 2.5 5.8 2.6 8.7 5.8 5.1 4.7 5.7 6.0 7.1 11.3 5.5 3.9 5.8 3.0 0.1 0.5 0.2 0.2 0.3 0.5 0.3 0.2 0.2 0.1 0.3 0.3 0.2 0.2 0.4 0.2 0.2 0.1 0.1 7.7 9.9 11.3 20.0 6.9 13.9 17.4 9.1 18.9 6.3 16.9 13.8 16.2 6.4 11.8 75.7 11.5 10.7 12.1 11.8 26.2 36.3 9.6 7.6 17.6 12.8 10.0 9.2 37.5 4.1 9.1 3.9 0.0 5.7 80.5 24.9 11.7 17.0 14.3 17.4 153.8 4.3 3.2 15.5 4.6 4.6 19.0 16.2 17.5 9.8 7.4 45.4 185.1 5.1 2.0 16.0 25.9 146.2 16.8 16.4 12.4 69.3 16.9 16.5 6.2 97.5 125.6 7.5 2.6 20.3 6.6 12.4 5.5 5.5 40.5 39.4 13.1 24.6 16.3 34.5 10.1 12.5 9.2 3.1 13.4 11.3 5.3 7.4 TTF1 ENSG00000125482 "Transcription termination factor 1" Q15361 9 132375548-132406851 "Human disease related genes, Predicted intracellular proteins" "Transcription, Transcription regulation, Transcription termination" "DNA replication inhibitor, DNA-binding" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054837 Supported Supported Nucleoplasm,Nucleoli NA NA "Cluster 6: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 6: Erythroid cells - Oxygen transport" "Nucleoplasm, Nucleoli" "HPA054837: AB_2682621" "unprognostic (7.07e-2)" "unprognostic (5.62e-3)" "unprognostic (9.12e-2)" "unprognostic (6.05e-2)" "unprognostic (1.66e-1)" "unprognostic (1.22e-1)" "prognostic unfavorable (1.40e-4)" "unprognostic (1.07e-1)" "unprognostic (9.21e-3)" "unprognostic (3.08e-1)" "unprognostic (1.33e-1)" "unprognostic (6.95e-3)" "unprognostic (2.09e-2)" "unprognostic (5.93e-3)" "unprognostic (8.38e-2)" "unprognostic (3.44e-1)" "unprognostic (4.71e-2)" 8.0 5.0 7.0 6.2 7.7 16.7 9.6 9.0 8.3 7.4 6.7 9.6 4.7 8.5 9.0 6.4 7.3 5.3 13.3 6.9 7.3 6.6 4.2 7.0 10.5 7.0 7.1 8.6 6.6 7.0 5.0 6.5 7.1 7.9 6.6 8.6 6.1 7.4 13.6 7.1 6.5 7.1 6.8 7.9 6.5 9.6 7.1 18.9 10.4 10.3 10.0 7.9 6.9 8.3 12.5 11.5 16.4 14.8 9.0 11.5 14.7 14.1 10.7 16.2 12.0 11.8 13.2 20.9 11.5 10.6 18.3 29.7 18.5 10.8 17.1 13.9 12.6 9.6 17.2 9.5 9.1 25.6 14.9 7.1 12.0 13.8 10.5 13.1 14.0 34.1 19.3 17.5 12.7 19.0 59.8 15.5 30.0 22.3 16.8 37.1 22.8 24.9 13.1 10.1 14.4 24.8 19.8 14.4 10.7 15.3 17.9 13.7 13.2 25.0 15.8 21.8 16.8 8.2 24.8 25.0 14.7 20.6 25.1 17.0 5.8 12.0 6.6 6.0 8.6 13.6 8.4 7.8 3.6 12.2 9.3 7.0 20.9 8.2 7.4 11.2 9.6 3.3 7.0 7.7 9.0 8.3 6.9 7.3 7.0 7.1 7.1 6.8 7.1 8.3 26.8 25.6 21.6 12.7 35.4 9.8 21.9 26.9 7.4 27.2 11.8 15.5 40.1 25.8 18.3 18.4 60.5 23.8 33.2 14.8 19.6 28.5 22.9 26.2 21.4 29.5 12.1 68.0 12.4 21.2 22.8 17.5 15.3 16.8 22.8 28.8 27.5 8.3 18.7 30.3 10.6 15.4 20.3 22.0 12.1 6.8 23.6 17.4 1.8 14.0 30.1 20.3 41.2 9.5 19.2 25.3 18.6 25.9 14.3 22.8 16.5 19.3 29.2 55.0 26.3 21.9 24.1 47.4 61.8 7.5 8.5 25.2 28.2 16.8 19.7 24.5 TTLL5 KIAA0998 ENSG00000119685 "Tubulin tyrosine ligase like 5" Q6EMB2 14 75633625-75955079 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Transcription Ligase "Cone-rod dystrophy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 57.4" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 127.2;Early spermatids: 111.0;Excitatory neurons: 134.3;Inhibitory neurons: 114.2;Oligodendrocytes: 242.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA032128 Uncertain Supported "Plasma membrane,Cytosol" NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 77: Retina - Visual perception" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Plasma membrane, Cytosol" "HPA032128: AB_10600835" "unprognostic (7.35e-2)" "unprognostic (7.29e-2)" "unprognostic (7.73e-2)" "unprognostic (1.10e-1)" "unprognostic (1.33e-1)" "unprognostic (5.96e-2)" "unprognostic (7.21e-5)" "unprognostic (1.26e-1)" "unprognostic (1.70e-1)" "unprognostic (7.93e-2)" "unprognostic (1.10e-2)" "unprognostic (3.43e-1)" "unprognostic (5.67e-3)" "unprognostic (1.70e-1)" "unprognostic (1.57e-1)" "unprognostic (8.97e-2)" "unprognostic (2.15e-2)" 5.5 5.5 3.7 6.0 6.0 11.7 7.1 7.1 7.2 7.3 15.0 6.2 4.7 8.0 7.2 7.8 11.6 6.5 5.8 3.8 6.6 6.2 4.1 6.5 5.1 10.5 6.4 7.1 4.9 11.1 5.4 7.5 10.6 6.9 7.3 23.9 6.5 6.9 4.7 7.1 4.5 8.6 6.4 4.1 5.9 57.4 6.4 10.1 7.8 5.8 7.5 6.1 6.4 12.0 22.8 16.2 13.9 14.5 10.9 16.8 12.9 13.1 15.9 15.4 19.9 10.3 20.8 6.4 7.2 13.9 11.3 21.3 12.3 21.7 29.3 7.6 7.3 12.5 16.8 11.3 9.3 9.2 11.5 13.1 10.6 19.4 21.5 16.8 33.8 17.5 7.2 10.5 15.7 32.1 15.6 12.6 9.9 18.0 16.6 9.5 19.6 8.8 15.0 22.2 18.4 11.6 27.5 20.2 6.8 11.0 27.6 9.8 38.1 20.5 18.0 18.5 12.2 8.8 13.5 14.6 20.7 10.4 13.9 11.6 2.0 1.7 2.6 2.0 2.4 2.3 2.5 2.7 3.2 1.8 2.9 2.7 2.4 2.3 2.5 3.4 2.2 1.4 3.7 6.0 7.1 7.2 3.8 6.6 10.5 6.4 10.6 6.4 6.4 12.0 7.1 3.2 10.1 71.8 6.1 5.0 5.5 5.4 8.0 10.9 17.3 11.6 8.7 17.2 10.2 11.0 127.2 8.1 8.5 7.6 3.9 7.1 111.0 37.4 11.9 10.7 7.7 5.0 134.3 5.3 13.2 9.3 8.6 10.8 12.6 11.7 19.6 7.4 5.6 0.0 114.2 6.5 16.2 5.8 5.1 93.1 12.5 6.6 5.4 82.4 8.5 10.0 6.2 78.4 242.9 6.1 11.9 11.7 7.6 6.2 6.0 2.4 40.1 80.1 13.1 9.5 6.0 37.7 16.4 9.0 6.3 6.0 8.3 9.1 8.0 4.6 TTR "CTS, CTS1, HsT2651, PALB" ENSG00000118271 Transthyretin P02766 18 31557009-31598833 "Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" Transport "Hormone, Thyroid hormone" "Amyloidosis, Cancer-related genes, Disease variant, FDA approved drug targets, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 7 "choroid plexus: 142023.1" "Cell type enriched" "Detected in many" 30 "Hepatocytes: 23659.3" "Group enriched" "Detected in many" 28 "liver cancer: 928.2;pancreatic cancer: 666.0" "Group enriched" "Detected in all" 7 "cerebellum: 621.7;hippocampal formation: 1730.9;thalamus: 688.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CACO-2: 160.1;EFO-21: 39.6;Hep G2: 249.0;U-2 OS: 57.0" "Group enriched" "Detected in all" 5 "basal ganglia: 1538.3;hippocampal formation: 4891.0;pons and medulla: 5758.5;thalamus: 3400.4" "Region enhanced" "Detected in all" "medulla oblongata: 1381.8" "CAB002517, HPA002550, CAB062567, CAB073406" Supported Approved "Golgi apparatus" "Secreted to blood" NA NA 345000000000 99000000000 "Cluster 1: Neutrophils - Mixed function" "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 39: CACO-2 - Unknown function" "Cluster 2: Hepatocytes - Metabolism" "Golgi apparatus" "CAB002517: AB_563965, CAB062567: AB_2665620, CAB073406: , HPA002550: AB_1080419" "unprognostic (6.79e-3)" "unprognostic (3.38e-2)" "unprognostic (4.10e-1)" "unprognostic (1.74e-1)" "unprognostic (1.84e-2)" "unprognostic (8.15e-2)" "unprognostic (3.74e-2)" "unprognostic (9.66e-3)" "unprognostic (8.72e-2)" "unprognostic (1.23e-2)" "unprognostic (8.35e-3)" "unprognostic (5.26e-1)" "unprognostic (3.52e-2)" 4.2 0.6 148.5 0.5 56.7 9.6 0.4 621.7 83.7 2.0 142023.1 6.0 14.9 1.3 0.9 2.2 0.8 51.2 2.9 1730.9 37.3 18.4 21288.1 0.8 2.4 106.5 86.0 1.1 1785.1 186.8 6.0 2.7 27.1 1.6 4.5 80.1 1.8 0.4 1.1 15.6 6.8 0.3 12.3 3.8 49.8 2.3 688.2 1.1 1.3 0.0 0.1 2.3 0.6 133.9 1.6 0.4 0.6 0.5 0.8 0.1 1.0 0.8 0.3 0.0 0.0 160.1 0.0 2.9 39.6 0.5 0.6 0.4 0.0 0.3 0.0 5.9 0.8 5.2 1.8 249.0 0.4 11.2 1.0 0.1 0.1 0.1 0.0 0.7 0.0 0.3 2.8 0.4 0.0 0.5 0.4 0.7 0.6 4.5 0.3 0.3 7.4 0.2 0.3 1.6 0.9 1.1 5.8 0.0 0.2 1.7 0.6 0.2 1.7 2.4 57.0 0.5 4.3 1.0 2.6 17.6 0.7 4.3 0.2 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.3 0.0 0.1 0.4 0.1 0.0 0.1 0.0 0.0 148.5 56.7 621.7 83.7 1730.9 37.3 106.5 86.0 27.1 12.3 688.2 133.9 0.0 0.0 0.0 0.0 15.1 0.5 0.0 0.0 0.0 144.8 0.0 0.0 1.8 779.2 0.0 5.5 162.6 0.3 0.0 1.5 5.9 3.1 6.8 0.5 0.5 14.1 356.2 192.5 0.0 2.0 3.6 0.7 13.3 0.0 0.0 0.2 192.4 23659.3 2.4 26.9 0.1 19.6 0.0 313.7 0.0 8.7 0.3 1.2 0.0 0.0 0.0 24.9 0.0 0.0 0.0 130.5 5.2 0.0 0.0 0.2 1.3 26.9 0.0 56.0 0.0 0.0 0.3 3.3 1.1 0.0 0.1 4.0 10.9 0.0 1.7 0.0 TUBA3D H2-ALPHA ENSG00000075886 "Tubulin alpha 3d" P0DPH8 2 131476119-131482934 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 15 "heart muscle: 86.2;testis: 220.2" "Cell type enhanced" "Detected in some" "Early spermatids: 358.9;Late spermatids: 119.6;Spermatocytes: 667.9;Spermatogonia: 326.1" "Cancer enhanced" "Detected in many" "testis cancer: 7.6" "Region enhanced" "Detected in single" "cerebellum: 1.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "NB-4: 1.1" "Not detected" "Not detected" "CAB004972, HPA039247, HPA043684, HPA063394" Uncertain Supported Microtubules NA NA "Cluster 43: Testis - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Microtubules "CAB004972: AB_425727, HPA039247: AB_2676410, HPA043684: AB_2678617, HPA063394: AB_2685003" "prognostic favorable (4.65e-4)" "unprognostic (6.66e-2)" "unprognostic (1.10e-1)" "unprognostic (2.96e-3)" "unprognostic (1.82e-1)" "unprognostic (1.50e-3)" "unprognostic (2.17e-1)" "unprognostic (2.06e-2)" "unprognostic (1.39e-1)" "unprognostic (2.89e-1)" "unprognostic (1.08e-1)" "unprognostic (2.05e-1)" "prognostic unfavorable (4.75e-9)" "unprognostic (4.60e-2)" "unprognostic (2.28e-1)" "unprognostic (9.96e-4)" "unprognostic (2.28e-1)" 0.1 0.1 0.4 0.2 0.3 0.4 0.6 1.6 0.4 2.8 0.0 0.1 0.1 4.8 6.8 0.2 4.0 0.2 86.2 0.6 0.2 0.1 0.4 0.1 0.4 0.0 0.0 0.5 0.2 0.0 0.1 0.0 0.0 10.1 0.0 0.3 0.3 0.4 0.1 0.6 0.2 0.3 0.0 0.2 0.2 220.2 0.0 0.0 0.3 0.0 0.0 0.1 0.3 0.0 0.5 0.2 0.2 0.9 0.0 0.0 0.6 0.2 0.0 0.0 0.0 0.8 0.3 0.3 0.1 0.0 0.0 0.6 0.0 0.0 0.0 0.4 0.7 0.1 0.6 0.3 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.7 0.3 0.0 0.5 0.5 1.1 0.7 0.0 0.3 0.4 0.0 0.2 0.0 0.2 0.5 0.1 0.2 0.0 0.0 0.2 0.1 0.0 0.2 0.3 0.4 0.5 0.3 0.1 0.2 0.2 0.2 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.3 1.6 0.4 0.6 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.3 0.4 36.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 358.9 0.4 1.1 1.2 0.0 0.0 0.4 0.0 0.1 0.6 0.0 1.1 0.0 0.4 0.0 0.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 119.6 12.2 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 10.1 0.0 4.8 0.0 0.0 0.0 0.0 52.6 0.0 0.1 667.9 326.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 TUBA4A "FLJ30169, H2-ALPHA, TUBA1" ENSG00000127824 "Tubulin alpha 4a" P68366 2 219249710-219278170 "Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Amyotrophic lateral sclerosis, FDA approved drug targets, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 360.2;tongue: 210.3" "Cell type enhanced" "Detected in many" "Early spermatids: 423.0;Late spermatids: 823.0;Pancreatic endocrine cells: 613.5;Smooth muscle cells: 408.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HaCaT: 265.9;HBEC3-KT: 439.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004621, CAB005887, HPA039247, HPA043684, HPA063394" Approved Enhanced Microtubules NA NA 130000000 "Cluster 5: Granulocytes - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 10: Non-specific - Unknown function" Microtubules "CAB004621: AB_628411, CAB005887: AB_2288001, HPA039247: AB_2676410, HPA043684: AB_2678617, HPA063394: AB_2685003" "unprognostic (8.08e-2)" "unprognostic (2.31e-1)" "unprognostic (4.03e-2)" "unprognostic (2.56e-2)" "unprognostic (5.18e-3)" "unprognostic (3.99e-2)" "prognostic unfavorable (4.54e-6)" "unprognostic (1.52e-3)" "unprognostic (4.47e-1)" "unprognostic (8.85e-2)" "unprognostic (1.49e-2)" "unprognostic (5.27e-2)" "unprognostic (1.94e-1)" "unprognostic (2.70e-1)" "unprognostic (2.36e-1)" "unprognostic (7.38e-3)" "unprognostic (9.32e-2)" 14.3 41.4 33.6 34.1 47.5 107.1 16.4 22.3 133.1 27.7 8.1 32.9 18.6 9.8 10.1 84.8 12.6 13.5 97.7 42.6 32.3 31.9 29.5 26.7 56.7 46.3 27.3 12.9 18.2 34.6 23.1 5.0 31.4 19.7 27.8 39.2 46.9 22.4 360.2 161.4 35.5 12.8 3.9 56.8 30.6 32.4 14.9 16.9 12.3 210.3 63.4 22.6 57.3 54.0 106.0 90.0 0.0 0.3 9.1 6.9 0.3 16.2 49.7 2.8 1.9 20.4 106.7 144.2 172.2 11.7 172.7 265.9 49.3 439.9 3.9 81.7 0.7 184.2 154.5 15.4 7.3 60.9 60.8 6.7 158.0 23.7 49.2 27.4 17.3 2.4 20.5 91.3 100.6 4.3 0.3 107.9 32.3 83.2 107.4 6.5 139.0 84.5 129.7 7.5 85.8 1.5 213.2 18.7 0.7 1.8 8.0 50.9 12.3 49.8 27.4 58.4 56.7 38.0 48.8 171.4 183.3 116.4 2.5 141.7 63.3 170.2 107.1 45.7 110.1 124.9 150.3 142.8 20.9 95.5 140.2 138.4 331.2 82.0 71.9 3.8 143.8 270.9 33.6 47.5 22.3 133.1 42.6 32.3 46.3 27.3 31.4 3.9 14.9 54.0 55.3 44.8 47.1 16.3 160.6 181.8 201.2 235.3 68.9 123.3 42.3 51.6 60.9 28.6 62.0 49.7 77.2 0.7 311.6 87.3 140.8 199.3 423.0 9.8 3.3 36.5 107.9 56.2 34.8 205.6 0.5 11.5 40.8 26.1 15.8 0.1 36.0 33.0 6.0 67.3 22.5 141.9 48.8 15.3 54.9 823.0 16.8 159.5 78.2 9.4 27.8 38.6 50.4 10.6 10.6 613.5 51.2 7.5 202.3 46.7 87.5 137.5 11.1 72.9 0.0 21.1 408.5 5.7 5.0 130.6 244.5 2.5 290.1 1.4 58.9 113.0 TUBB3 "beta-4, CFEOM3, CFEOM3A, FEOM3" ENSG00000258947 "Tubulin beta 3 class III" Q13509 16 89921392-89938761 "Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "brain: 313.3" "Cell type enhanced" "Detected in some" "Astrocytes: 20.2;Ductal cells: 28.7;Excitatory neurons: 37.9;Exocrine glandular cells: 21.4;Gastric mucus-secreting cells: 27.0;Inhibitory neurons: 45.1;Pancreatic endocrine cells: 49.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 8 "naive B-cell: 2.5" "Lineage enriched" "Detected in single" 9 "B-cells: 2.5" "Cell line enhanced" "Detected in many" "A549: 421.3;SCLC-21H: 424.9;SH-SY5Y: 433.8" "Low region specificity" "Detected in all" "HPA043640, HPA046280" Approved Approved "Microtubules,Cytokinetic bridge,Mitotic spindle" Yes NA 89000000 "Cluster 24: B-cells - Unknown function" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 1: Pancreatic cells - Digestion" Microtubules "Cytokinetic bridge, Mitotic spindle" "HPA043640: AB_2678594, HPA046280: AB_2679612" "unprognostic (7.08e-2)" "unprognostic (3.37e-4)" "unprognostic (1.05e-1)" "unprognostic (1.06e-1)" "unprognostic (8.01e-2)" "unprognostic (3.12e-2)" "unprognostic (4.04e-3)" "unprognostic (1.12e-3)" "unprognostic (1.22e-2)" "unprognostic (6.06e-2)" "unprognostic (1.99e-2)" "unprognostic (1.38e-2)" "unprognostic (7.57e-2)" "unprognostic (1.27e-3)" "unprognostic (3.70e-2)" "unprognostic (3.05e-1)" "unprognostic (1.91e-2)" 5.7 24.8 99.4 12.1 93.3 3.4 2.1 100.5 127.6 3.3 0.0 18.4 3.7 9.7 0.2 3.6 2.3 8.8 5.5 88.6 313.3 13.3 0.9 4.1 7.1 208.8 132.7 3.9 3.2 0.4 55.1 1.8 266.2 3.0 2.6 24.8 10.6 0.4 0.6 5.2 8.0 12.7 74.2 1.3 7.2 38.0 183.4 1.0 2.5 0.3 5.2 7.3 5.3 82.5 30.1 421.3 152.6 173.9 17.9 170.8 6.8 181.0 31.0 105.8 48.2 57.2 53.5 89.6 93.6 136.8 74.3 112.1 148.9 26.7 26.3 22.7 15.5 0.7 32.5 383.7 6.0 0.0 67.6 98.4 7.9 161.9 14.0 136.8 88.4 5.9 9.2 2.5 122.3 288.6 1.2 31.5 274.3 11.2 237.3 0.1 54.1 9.5 131.8 8.1 424.9 433.8 251.2 4.4 137.1 27.5 15.0 1.9 110.9 142.8 156.9 197.3 185.3 1.4 19.6 35.2 150.2 11.5 260.8 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 99.4 93.3 100.5 127.6 88.6 313.3 208.8 132.7 266.2 74.2 183.4 82.5 0.4 0.0 0.0 20.2 0.0 0.0 0.0 0.0 3.4 1.8 0.2 0.1 0.0 0.0 0.6 0.0 0.0 0.1 0.0 0.1 0.0 28.7 8.2 0.5 2.6 3.8 4.9 0.0 37.9 21.4 0.7 6.1 27.0 0.7 0.0 0.0 0.0 0.0 0.2 5.0 45.1 0.1 0.0 0.0 0.0 16.8 0.3 0.2 0.0 9.4 0.0 0.3 0.0 16.1 9.2 49.2 0.0 0.4 0.4 0.0 0.0 0.1 0.0 1.4 0.0 0.0 5.1 0.2 0.4 3.0 0.0 1.0 0.1 0.0 0.2 0.0 TUBB4B "Beta2, TUBB2C" ENSG00000188229 "Tubulin beta 4B class IVb" P68371 9 137241287-137243707 "Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Deafness, Disease variant, FDA approved drug targets, Leber congenital amaurosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 2190.0;Late spermatids: 2907.1;Spermatocytes: 1717.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010880, HPA043640, HPA046280" Enhanced Supported "Microtubules,Cytokinetic bridge,Mitotic spindle" Yes Yes "Cluster 38: Basophils - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 7: Non-specific - Mitochondria" Microtubules "Cytokinetic bridge, Mitotic spindle" "CAB010880: AB_609915, HPA043640: AB_2678594, HPA046280: AB_2679612" "unprognostic (2.24e-1)" "unprognostic (1.77e-3)" "unprognostic (1.50e-1)" "prognostic favorable (4.91e-4)" "unprognostic (1.29e-2)" "unprognostic (8.93e-2)" "prognostic unfavorable (9.98e-4)" "unprognostic (9.92e-3)" "unprognostic (2.90e-1)" "unprognostic (3.63e-1)" "unprognostic (2.34e-1)" "unprognostic (4.09e-2)" "unprognostic (2.47e-3)" "unprognostic (6.37e-2)" "unprognostic (1.36e-2)" "prognostic favorable (6.36e-6)" "unprognostic (1.69e-1)" 134.5 112.6 162.0 97.2 163.4 423.9 94.4 149.4 182.7 88.1 482.7 198.3 142.0 107.7 209.1 343.3 507.2 106.0 435.8 174.0 185.2 122.5 140.1 130.5 95.5 184.1 233.6 72.9 123.8 87.8 118.0 86.3 213.9 120.2 111.9 261.8 177.9 121.5 202.5 240.0 166.4 119.8 162.9 85.6 161.4 765.7 192.6 162.9 115.7 96.6 119.7 188.3 139.4 133.9 706.2 1032.5 431.7 314.2 213.2 223.6 600.5 643.7 536.0 872.4 598.6 1101.0 840.2 429.0 480.2 631.2 848.2 1305.1 539.5 1039.2 330.2 307.9 458.5 311.2 789.6 877.8 134.5 370.0 331.5 145.0 291.5 667.5 183.1 215.7 631.7 300.6 443.0 239.7 731.2 1936.4 337.4 504.2 457.8 1234.8 1778.1 423.5 822.2 394.2 666.8 647.8 301.5 323.6 853.9 485.8 173.2 244.2 699.0 397.6 495.6 618.1 685.0 710.0 863.6 92.4 274.9 475.1 503.6 286.9 549.8 95.7 30.0 43.2 40.5 30.1 38.2 32.6 31.3 34.4 34.9 30.8 19.7 26.7 56.4 24.4 30.5 36.3 44.7 32.6 162.0 163.4 149.4 182.7 174.0 185.2 184.1 233.6 213.9 162.9 192.6 133.9 478.5 221.2 146.3 21.5 315.8 326.2 945.7 458.7 327.2 508.1 286.9 389.5 91.9 143.0 284.1 143.5 300.3 346.6 640.9 744.1 221.1 348.6 2190.0 1191.6 224.8 203.9 391.5 419.9 30.1 446.8 545.5 247.8 274.7 415.0 189.2 200.9 142.5 139.2 265.9 244.0 24.3 503.6 323.5 59.9 214.9 2907.1 254.2 299.3 138.7 22.5 224.0 299.3 49.4 15.6 19.7 477.4 697.2 153.1 264.0 475.1 540.7 345.5 1558.7 763.3 111.7 261.8 416.0 1717.5 740.9 419.1 297.6 321.1 362.9 89.8 487.3 592.7 TULP1 "LCA15, RP14, TUBL1" ENSG00000112041 "TUB like protein 1" O00294 6 35497874-35512896 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Phagocytosis, Sensory transduction, Vision" "Disease variant, Leber congenital amaurosis, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 286 "retina: 209.1" "Group enriched" "Detected in some" 5 "Cone photoreceptor cells: 266.9;Rod photoreceptor cells: 393.2" "Low cancer specificity" "Detected in single" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 2.7;MCF7: 1.5" "Not detected" "Not detected" "Not detected" "Not detected" "Intracellular and membrane" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 28: BEWO - Transcription regulation" "Cluster 46: Photoreceptor cells - Phototransduction" "unprognostic (7.98e-2)" "unprognostic (2.33e-2)" "unprognostic (4.38e-2)" "unprognostic (4.60e-5)" "unprognostic (2.28e-2)" "unprognostic (3.12e-3)" "unprognostic (3.30e-1)" "unprognostic (5.49e-3)" "unprognostic (1.85e-1)" "unprognostic (2.66e-2)" "unprognostic (7.42e-2)" "unprognostic (1.66e-6)" "unprognostic (1.72e-1)" "unprognostic (1.30e-1)" "unprognostic (5.42e-2)" "unprognostic (4.11e-2)" 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.3 0.4 0.3 0.1 0.0 0.3 0.4 0.2 0.5 0.0 0.1 0.2 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.2 0.1 0.0 0.7 0.0 209.1 0.2 0.3 0.0 0.5 0.1 0.0 0.1 0.1 0.1 0.3 0.0 0.0 0.1 0.0 0.0 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.2 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 64.2 0.0 0.0 0.7 0.0 0.0 0.0 266.9 0.2 0.0 0.0 0.0 0.0 0.2 0.1 0.3 2.6 0.0 0.0 0.1 0.0 2.4 0.2 0.0 0.1 0.0 0.1 0.0 0.0 0.1 18.5 0.1 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 55.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 393.2 0.0 0.4 0.2 0.1 0.7 0.0 0.0 2.2 0.0 0.0 0.0 0.4 TWNK "C10orf2, FLJ21832, IOSCA, PEO, PEO1, TWINKLE, TWINL" ENSG00000107815 "Twinkle mtDNA helicase" Q96RR1 10 100987367-100994403 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "DNA replication" "Helicase, Hydrolase" "Deafness, Disease variant, Neurodegeneration, Neuropathy, Primary mitochondrial disease, Progressive external ophthalmoplegia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Breast glandular cells: 6.8;Breast myoepithelial cells: 6.6;Ductal cells: 5.4;Endometrial stromal cells: 7.2;Granulosa cells: 7.1;Theca cells: 9.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002532 Uncertain NA NA "Cluster 44: Non-specific - Transcription" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" "HPA002532: AB_1078311" "unprognostic (8.10e-2)" "unprognostic (9.65e-2)" "unprognostic (1.16e-1)" "unprognostic (2.19e-2)" "unprognostic (2.81e-2)" "unprognostic (1.19e-1)" "unprognostic (7.82e-3)" "unprognostic (7.99e-2)" "unprognostic (1.22e-1)" "unprognostic (7.95e-2)" "unprognostic (7.52e-2)" "unprognostic (1.96e-2)" "unprognostic (9.46e-2)" "unprognostic (9.82e-3)" "unprognostic (1.64e-1)" "unprognostic (1.36e-1)" "unprognostic (1.45e-1)" 4.9 7.0 3.7 5.5 3.7 3.0 7.5 3.6 3.5 3.8 3.2 4.4 3.3 4.6 5.3 5.5 6.6 2.6 5.0 3.4 3.6 5.9 6.0 2.1 6.1 3.9 4.0 5.1 5.2 4.8 2.4 3.8 3.8 4.0 4.8 1.6 4.0 3.4 11.6 5.5 3.8 4.5 3.7 4.6 3.9 8.3 4.0 8.1 4.1 12.6 8.3 6.6 3.5 3.5 15.5 32.0 12.5 39.7 11.1 7.2 14.7 11.4 14.8 17.3 16.6 52.6 13.1 55.4 21.1 7.0 10.4 25.0 52.2 27.7 21.1 25.5 31.0 42.1 17.4 40.2 19.1 54.8 16.7 14.9 30.7 25.5 77.6 15.8 10.6 26.3 45.9 15.0 12.3 21.2 37.0 18.8 35.8 28.2 25.9 35.5 27.5 33.2 10.7 15.4 20.1 38.5 12.0 16.0 37.8 13.8 20.9 16.0 12.4 8.6 17.4 10.6 32.5 28.0 31.3 46.0 10.6 47.8 9.8 1.2 0.6 0.1 1.2 0.5 3.7 2.4 1.8 2.7 1.2 2.1 2.0 2.2 0.0 2.5 0.8 1.3 0.4 1.4 3.7 3.7 3.6 3.5 3.4 3.6 3.9 4.0 3.8 3.7 4.0 3.5 3.5 0.0 2.6 0.0 1.0 0.0 0.0 0.0 0.0 0.0 6.8 6.6 0.0 0.0 3.1 1.8 0.0 4.2 1.9 0.0 3.9 5.4 0.0 2.3 7.2 2.0 0.0 0.0 0.0 3.0 3.7 1.3 0.0 2.8 1.3 7.1 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 1.0 0.0 0.0 0.0 0.0 4.5 0.0 0.0 0.4 0.0 0.0 2.3 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 1.6 1.1 9.1 0.0 0.0 UBA1 "A1S9T, CFAP124, GXP1, POC20, UBE1, UBE1X" ENSG00000130985 "Ubiquitin like modifier activating enzyme 1" P22314 X 47190861-47215128 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Ligase "Cancer-related genes, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000289, HPA001506, CAB019435, CAB073410" Approved Supported Nucleoplasm NA NA 14000000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "CAB019435: AB_2211440, CAB073410: , HPA000289: AB_1080443, HPA001506: AB_2756305" "unprognostic (7.18e-3)" "unprognostic (1.52e-1)" "unprognostic (7.54e-2)" "unprognostic (2.40e-1)" "unprognostic (9.29e-2)" "unprognostic (1.02e-1)" "prognostic unfavorable (6.10e-5)" "unprognostic (7.22e-2)" "unprognostic (2.42e-3)" "unprognostic (3.43e-2)" "unprognostic (8.50e-3)" "unprognostic (2.17e-3)" "unprognostic (1.85e-3)" "unprognostic (1.13e-1)" "unprognostic (5.38e-2)" "prognostic favorable (1.78e-4)" "unprognostic (1.21e-2)" 98.4 157.9 102.9 98.3 113.2 94.3 98.6 103.4 115.5 127.9 133.9 101.1 71.3 127.1 64.3 155.3 119.3 64.9 117.4 106.2 102.0 131.2 114.7 109.5 105.0 106.9 104.2 136.5 89.0 107.5 135.2 67.4 109.3 103.2 68.5 95.6 119.5 78.9 201.1 119.5 100.4 117.4 94.4 131.9 98.6 98.7 110.0 119.7 160.1 114.1 110.8 101.1 124.8 121.3 269.1 273.2 307.7 471.9 207.4 186.8 135.0 175.1 187.1 248.6 200.5 219.3 201.3 201.6 111.8 357.0 361.5 254.9 392.9 375.7 180.9 163.4 391.7 126.1 295.2 180.0 145.1 215.2 258.8 177.4 193.2 362.7 279.4 176.7 330.2 236.1 138.9 173.7 250.4 343.4 203.3 188.5 329.6 163.2 417.1 233.1 215.3 343.7 198.7 287.0 197.4 148.1 520.8 250.9 116.9 329.9 349.5 130.3 241.6 183.1 210.7 266.4 166.1 117.6 132.8 286.3 189.4 150.8 224.9 31.0 39.7 40.7 39.4 51.1 34.0 39.8 31.8 35.0 43.2 29.9 24.7 31.1 44.8 38.1 49.7 29.3 40.3 39.9 102.9 113.2 103.4 115.5 106.2 102.0 106.9 104.2 109.3 94.4 110.0 121.3 37.2 51.3 34.7 45.1 37.1 33.6 38.6 55.7 26.2 24.9 48.3 39.6 51.4 51.5 50.0 82.8 16.7 46.3 34.2 133.1 35.2 77.5 29.6 84.9 56.3 40.9 57.5 33.2 27.1 90.8 68.7 45.0 74.9 97.5 18.3 60.3 43.5 51.2 60.0 11.8 35.5 78.6 30.5 49.0 37.8 61.6 42.3 51.4 19.6 31.9 57.7 20.7 13.4 32.2 46.5 147.9 74.7 65.8 44.0 55.2 82.2 61.6 56.4 25.1 39.5 38.8 56.6 10.5 34.0 51.3 42.1 71.1 34.6 56.8 68.2 55.4 UBA5 "FLJ23251, UBE1DC1" ENSG00000081307 "Ubiquitin like modifier activating enzyme 5" Q9GZZ9 3 132654446-132679794 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" "Disease variant, Epilepsy, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 418.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017235, HPA076042" Supported Enhanced Vesicles,Cytosol NA NA 43000 "Cluster 15: NK-cells - Transcription" "Cluster 29: Non-specific - Vesicular transport" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 25: Spermatids - Spermatogenesis" Cytosol Vesicles "HPA017235: AB_1858507, HPA076042: " "unprognostic (4.34e-3)" "unprognostic (6.44e-2)" "unprognostic (7.70e-2)" "unprognostic (3.49e-1)" "unprognostic (8.25e-2)" "unprognostic (1.25e-1)" "unprognostic (1.19e-2)" "unprognostic (3.06e-1)" "unprognostic (3.28e-2)" "unprognostic (1.47e-1)" "unprognostic (1.15e-2)" "unprognostic (1.84e-2)" "unprognostic (3.56e-1)" "unprognostic (1.47e-1)" "unprognostic (8.08e-2)" "unprognostic (1.02e-2)" "unprognostic (2.40e-2)" 18.3 29.2 15.6 18.6 17.5 21.5 23.0 15.2 16.3 18.0 30.9 21.5 24.0 17.2 30.4 17.2 16.6 16.9 23.8 16.7 15.8 31.3 31.8 17.7 22.4 12.6 13.6 16.9 52.1 31.0 22.3 25.8 14.1 24.8 22.6 25.2 48.0 20.2 31.4 22.0 24.8 17.7 13.8 21.1 26.7 17.0 14.2 19.7 31.8 24.4 24.9 17.2 11.8 16.5 67.2 24.4 42.1 35.3 28.4 31.9 44.5 57.1 57.2 34.4 39.6 44.9 24.2 52.1 41.1 40.8 23.3 39.6 41.6 43.6 49.5 51.3 18.1 63.6 39.6 50.1 27.9 79.6 36.7 28.0 24.8 32.8 48.7 31.8 38.6 28.6 41.0 76.2 38.0 59.4 44.1 29.2 38.6 56.3 22.9 38.6 37.0 99.8 31.0 50.9 40.2 35.8 33.5 32.0 51.3 37.8 40.0 39.5 35.9 36.7 36.2 17.8 29.8 71.7 51.8 98.3 40.9 28.1 33.5 8.3 7.1 7.0 12.4 8.2 14.6 15.1 13.8 19.1 15.9 10.2 16.1 16.3 1.6 26.0 9.5 19.2 15.5 10.5 15.6 17.5 15.2 16.3 16.7 15.8 12.6 13.6 14.1 13.8 14.2 16.5 23.1 35.3 25.9 37.2 24.0 17.2 18.9 26.4 21.1 22.1 26.1 13.1 36.9 22.8 24.4 7.3 14.6 63.0 28.4 8.3 68.4 30.3 124.8 17.7 22.2 20.5 21.6 10.9 37.6 44.9 48.0 24.8 28.5 17.4 24.1 16.8 13.2 22.8 22.6 21.9 35.6 22.6 34.6 10.3 11.4 418.2 16.8 13.9 17.8 16.9 21.6 26.1 16.5 37.7 28.4 23.2 16.7 27.1 85.4 23.1 35.4 43.1 20.8 23.6 32.9 23.5 28.2 49.4 23.1 15.9 18.5 99.7 20.4 29.7 18.3 18.1 UBAP1 UBAP ENSG00000165006 "Ubiquitin associated protein 1" Q9NZ09 9 34179005-34252523 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Protein transport, Transport" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019804 Approved Supported "Vesicles,Plasma membrane,Cytosol" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 30: Epithelial cell lines - Translation" "Cluster 44: Endometrium - Transcription" Cytosol "Vesicles, Plasma membrane" "HPA019804: AB_1858494" "unprognostic (1.83e-1)" "unprognostic (4.30e-2)" "unprognostic (1.29e-1)" "unprognostic (1.70e-1)" "unprognostic (3.54e-1)" "unprognostic (3.29e-2)" "unprognostic (1.67e-1)" "unprognostic (1.59e-1)" "unprognostic (2.01e-2)" "unprognostic (6.53e-2)" "unprognostic (1.25e-2)" "unprognostic (3.63e-1)" "prognostic favorable (7.49e-6)" "unprognostic (1.24e-1)" "unprognostic (1.49e-1)" "unprognostic (2.46e-1)" "unprognostic (1.17e-1)" 40.7 55.5 46.4 24.5 47.1 131.5 35.8 48.0 53.4 45.0 46.4 38.5 22.3 34.0 25.5 69.7 33.9 30.4 38.2 45.6 48.2 34.8 53.1 42.5 23.8 48.5 48.5 40.9 28.0 34.4 25.6 29.3 49.4 30.4 24.8 44.8 29.6 30.6 110.0 39.5 26.3 35.2 46.3 28.2 33.6 47.8 49.9 31.6 25.6 71.7 32.7 38.0 45.8 48.2 56.7 31.7 35.2 38.4 63.6 39.3 29.8 44.4 61.6 48.4 65.6 34.3 23.0 39.3 19.5 66.5 41.1 28.3 49.2 69.5 46.4 57.1 22.3 35.1 65.4 35.5 57.8 39.3 44.8 48.7 113.0 57.5 75.0 73.4 54.4 37.9 27.4 38.0 45.7 23.7 36.5 55.0 38.2 38.8 45.9 32.6 24.8 22.8 104.2 36.9 19.9 28.1 49.0 50.2 22.5 31.1 24.6 38.5 39.2 24.7 38.0 37.4 41.5 18.9 25.3 41.0 49.5 31.5 74.2 26.8 50.9 66.6 38.0 45.2 65.8 26.8 38.1 40.0 47.1 23.2 36.3 29.8 120.2 50.1 41.0 26.7 52.9 55.0 46.4 47.1 48.0 53.4 45.6 48.2 48.5 48.5 49.4 46.3 49.9 48.2 21.6 67.3 26.0 44.4 22.4 46.9 66.3 20.4 45.5 15.8 27.9 23.1 13.1 20.0 33.5 7.3 25.0 33.2 21.6 25.8 19.6 34.8 77.5 56.9 37.2 21.4 16.1 50.7 33.1 40.1 35.4 31.2 44.4 90.0 25.9 15.4 17.5 25.3 22.0 6.7 42.9 18.5 30.5 21.4 39.8 62.9 29.2 38.2 24.9 26.2 23.1 26.0 13.4 38.7 35.4 44.3 23.0 42.5 25.0 47.9 22.5 21.0 22.5 10.9 19.7 44.0 32.5 51.0 22.9 54.6 59.0 89.6 28.6 20.8 18.8 70.9 UBIAD1 "SCCD, TERE1" ENSG00000120942 "UbiA prenyltransferase domain containing 1" Q9Y5Z9 1 11273198-11296049 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Menaquinone biosynthesis, Ubiquinone biosynthesis" "Prenyltransferase, Transferase" "Corneal dystrophy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044862 Approved Vesicles NA NA "Cluster 30: Non-specific - Translation" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" Vesicles "HPA044862: AB_2679117" "unprognostic (1.79e-2)" "unprognostic (2.26e-1)" "unprognostic (5.06e-2)" "unprognostic (1.74e-1)" "unprognostic (7.95e-3)" "unprognostic (7.55e-2)" "unprognostic (1.16e-2)" "unprognostic (2.01e-1)" "unprognostic (1.61e-1)" "unprognostic (2.55e-1)" "unprognostic (1.20e-1)" "unprognostic (1.63e-1)" "prognostic favorable (6.80e-5)" "unprognostic (3.00e-1)" "unprognostic (3.89e-1)" "unprognostic (2.03e-2)" "unprognostic (1.25e-1)" 7.3 7.5 5.5 7.6 7.5 7.6 8.3 6.9 7.0 6.8 2.3 7.0 5.5 8.4 6.1 5.9 9.6 4.6 8.2 5.2 6.1 6.5 10.1 6.1 10.2 7.5 7.5 11.5 10.8 10.0 5.8 6.4 6.8 7.1 6.8 8.0 7.0 6.6 17.7 8.1 6.4 7.9 6.6 7.1 7.2 9.2 7.1 11.9 7.7 13.8 10.5 8.1 5.6 10.1 14.5 14.1 11.0 21.3 8.0 7.4 14.8 15.6 12.7 16.4 14.9 16.4 13.1 28.5 15.6 11.1 15.4 19.5 28.1 18.7 19.9 20.0 24.1 19.1 14.5 22.0 14.5 29.5 15.9 11.2 24.9 22.2 26.3 8.7 12.2 25.8 23.1 22.9 11.2 14.8 19.1 14.7 13.3 27.1 20.7 18.0 24.6 34.6 12.7 9.5 13.6 14.5 16.6 16.3 21.5 4.5 12.1 15.3 10.2 14.4 15.5 15.1 20.5 18.6 27.9 52.4 9.2 38.3 18.3 11.5 12.8 19.5 24.3 17.5 27.3 45.3 32.5 24.8 16.9 42.1 48.5 33.3 3.9 20.5 15.6 21.1 33.8 22.2 5.5 7.5 6.9 7.0 5.2 6.1 7.5 7.5 6.8 6.6 7.1 10.1 9.4 9.6 14.6 4.2 19.6 15.4 16.7 11.2 22.2 11.9 13.3 13.7 8.3 11.5 18.1 5.5 8.4 10.6 17.5 7.4 11.7 10.8 34.1 6.3 9.6 9.5 4.9 13.3 4.2 13.3 14.7 11.4 13.3 9.6 7.0 11.3 7.9 19.7 8.7 13.5 6.5 11.1 14.2 8.2 14.1 23.1 12.5 9.5 5.4 4.7 7.1 9.5 14.4 9.0 11.1 11.0 5.3 10.9 14.2 15.0 5.8 8.6 8.9 15.8 0.0 20.2 10.4 24.7 15.7 15.7 12.6 18.9 14.4 12.0 14.1 10.3 UBQLN2 "Chap1, CHAP1/DSK2, Dsk2, LIC-2, N4BP4, PLIC-2, PLIC2, RIHFB2157" ENSG00000188021 "Ubiquilin 2" Q9UHD9 X 56563627-56567868 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" Autophagy "Amyotrophic lateral sclerosis, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006431, CAB013481" Enhanced Supported "Plasma membrane,Cytosol" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "Plasma membrane" "CAB013481: AB_2533341, HPA006431: AB_1078707" "unprognostic (1.23e-2)" "unprognostic (2.88e-1)" "unprognostic (1.47e-1)" "unprognostic (1.51e-3)" "unprognostic (1.76e-2)" "unprognostic (5.08e-2)" "prognostic unfavorable (2.29e-4)" "unprognostic (2.66e-1)" "unprognostic (1.25e-1)" "unprognostic (4.42e-1)" "unprognostic (1.55e-1)" "unprognostic (1.13e-1)" "unprognostic (8.81e-2)" "unprognostic (1.35e-1)" "unprognostic (1.45e-1)" "unprognostic (8.88e-2)" "unprognostic (8.42e-3)" 13.8 20.2 24.9 14.9 26.8 11.1 12.1 19.7 30.6 15.9 12.7 15.7 11.2 16.6 15.9 18.7 17.5 14.5 21.6 27.4 25.5 13.5 19.4 13.8 18.4 20.2 20.4 25.7 10.5 23.6 16.3 15.8 22.1 20.2 12.1 22.2 14.4 20.0 28.0 13.6 12.4 18.4 21.3 14.9 13.1 4.4 22.6 18.9 20.7 22.8 18.6 18.6 11.1 25.5 36.3 26.5 25.9 30.6 58.3 37.0 16.3 28.6 33.9 21.0 23.2 14.9 16.6 27.6 30.5 34.0 32.9 20.7 50.0 31.9 25.3 43.0 30.1 11.2 34.2 15.9 30.6 22.1 23.7 34.7 39.6 28.3 24.6 30.3 18.7 17.6 13.3 29.5 33.6 16.9 28.5 19.2 21.7 11.6 31.1 25.3 33.7 26.3 42.8 27.9 31.9 29.9 41.3 18.1 17.4 45.2 30.4 16.1 21.2 22.2 22.5 32.4 17.5 11.1 14.8 18.9 24.9 23.1 19.3 50.0 23.6 24.1 15.1 31.1 17.1 7.8 22.9 17.7 17.8 8.6 30.3 18.9 20.4 20.9 34.2 6.5 23.5 20.3 24.9 26.8 19.7 30.6 27.4 25.5 20.2 20.4 22.1 21.3 22.6 25.5 13.9 22.4 17.2 0.0 30.5 31.2 41.6 27.4 20.5 42.3 14.5 11.3 37.6 15.7 25.0 18.4 18.8 28.8 15.4 12.1 17.6 20.0 0.1 11.8 22.7 18.9 34.2 18.3 0.0 16.6 26.7 27.9 13.7 15.7 12.7 14.2 18.2 20.3 24.7 42.1 0.0 20.3 18.3 30.7 25.3 1.6 24.8 21.1 17.8 0.0 35.9 22.3 42.2 0.0 0.0 18.9 12.7 36.5 23.5 32.0 20.7 16.4 27.5 35.8 13.1 25.4 29.8 0.3 1.5 32.7 30.4 40.0 28.7 12.2 19.3 35.6 UBTF "NOR-90, UBF, UBF1, UBF2" ENSG00000108312 "Upstream binding transcription factor" P17480 17 44205033-44221626 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding" "Disease variant, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004611, HPA006385" Supported Supported Enhanced "Nucleoli fibrillar center" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 50: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" "Nucleoli fibrillar center" "CAB004611: AB_671403, HPA006385: AB_1080447" "unprognostic (1.37e-3)" "unprognostic (1.12e-3)" "unprognostic (2.54e-1)" "unprognostic (1.12e-2)" "unprognostic (3.15e-1)" "unprognostic (8.54e-3)" "unprognostic (1.35e-3)" "unprognostic (4.10e-2)" "unprognostic (5.39e-2)" "unprognostic (1.15e-1)" "unprognostic (1.12e-2)" "unprognostic (2.10e-1)" "unprognostic (1.96e-3)" "unprognostic (5.44e-2)" "unprognostic (9.01e-2)" "unprognostic (1.91e-2)" "unprognostic (2.00e-1)" 34.8 36.5 36.2 44.8 33.7 54.9 35.4 38.2 37.1 50.6 30.1 49.4 33.6 50.8 27.5 41.8 41.9 32.5 38.8 35.5 32.7 38.1 36.1 32.3 67.6 34.0 34.5 41.6 41.4 38.2 33.8 29.2 32.2 41.6 28.2 23.1 37.7 40.8 63.7 47.4 42.5 36.3 31.6 49.8 34.7 20.8 34.9 73.6 46.4 36.6 51.7 45.1 41.8 35.0 69.1 104.3 77.3 93.2 49.6 56.5 72.3 70.6 46.7 70.1 52.0 50.7 54.8 250.0 69.3 65.3 51.9 63.6 99.1 59.2 57.9 145.3 109.5 100.5 73.8 83.7 32.5 192.1 85.7 56.9 52.2 44.6 65.6 67.2 58.9 108.8 117.4 75.9 58.9 113.7 188.3 75.0 73.7 46.6 81.6 184.0 104.3 112.0 40.4 54.5 119.5 90.3 70.4 62.2 54.2 47.9 89.9 120.8 75.5 109.9 133.1 65.1 95.0 66.6 61.7 151.1 64.8 86.0 100.1 9.6 5.7 6.1 15.5 6.3 16.7 11.7 10.8 16.2 6.7 14.1 12.2 13.1 9.7 15.7 11.6 12.7 10.0 11.3 36.2 33.7 38.2 37.1 35.5 32.7 34.0 34.5 32.2 31.6 34.9 35.0 41.4 41.7 42.1 14.7 57.5 20.5 19.6 17.9 57.5 88.8 31.0 29.6 44.5 35.8 32.2 38.6 79.2 30.9 60.3 41.7 35.2 27.2 2.3 39.3 57.7 42.7 47.3 61.2 8.5 40.8 40.7 38.9 23.9 48.1 31.7 43.1 32.5 26.5 25.9 26.9 8.2 32.5 12.2 18.4 13.3 3.6 36.7 27.4 23.2 8.4 38.1 33.9 54.6 3.5 10.6 28.1 30.7 50.8 42.2 17.4 26.7 25.4 26.5 57.6 52.6 48.5 45.9 5.3 44.0 52.1 24.3 32.7 53.1 40.2 32.8 11.8 UCHL1 "PARK5, PGP9.5, Uch-L1" ENSG00000154277 "Ubiquitin C-terminal hydrolase L1" P09936 4 41256413-41268455 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 692.7;pituitary gland: 285.4" "Cell type enhanced" "Detected in many" "Collecting duct cells: 115.8;Distal tubular cells: 258.2;Excitatory neurons: 147.1;Horizontal cells: 146.4;Inhibitory neurons: 118.4;Spermatogonia: 88.4" "Cancer enhanced" "Detected in all" "glioma: 129.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "EFO-21: 1142.2;SCLC-21H: 1160.6;U-251 MG: 1162.6;U-266/84: 1138.4;U-87 MG: 1209.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002580, HPA005993, CAB079024" Enhanced Supported Supported Nucleoplasm,Cytosol NA NA 500000 "Cluster 43: B-cells - Humoral immune response" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 39: Non-specific - Basic cellular processes" Cytosol Nucleoplasm "CAB002580: AB_563981, CAB079024: , HPA005993: AB_1858560" "unprognostic (1.54e-1)" "unprognostic (1.96e-1)" "unprognostic (1.12e-1)" "prognostic unfavorable (4.08e-5)" "unprognostic (2.34e-1)" "unprognostic (1.98e-1)" "unprognostic (6.28e-3)" "unprognostic (1.09e-2)" "unprognostic (4.31e-2)" "unprognostic (8.77e-3)" "unprognostic (3.56e-3)" "unprognostic (3.70e-2)" "unprognostic (1.82e-3)" "unprognostic (1.24e-2)" "unprognostic (7.12e-3)" "unprognostic (2.10e-2)" "prognostic unfavorable (1.93e-4)" 30.1 104.4 211.4 19.2 188.8 0.6 13.6 83.4 342.7 18.9 0.0 49.0 9.0 13.2 3.3 3.3 9.7 12.3 26.9 229.7 692.7 62.7 1.6 8.2 12.9 255.7 205.2 35.6 11.6 0.6 285.4 2.5 446.7 12.3 6.9 38.3 3.7 5.8 27.5 4.7 18.9 9.2 122.2 2.7 14.5 16.5 150.3 4.1 9.8 7.7 7.3 31.7 29.1 231.2 3.3 712.8 146.8 0.4 18.9 19.7 0.4 681.4 352.8 236.0 243.4 149.0 0.9 0.0 1142.2 384.4 356.7 1.1 262.8 0.6 116.4 1.5 97.0 0.0 6.9 0.2 529.3 0.1 1.2 127.4 3.0 197.9 0.0 413.7 2.0 0.0 0.0 2.3 122.6 0.6 1.0 12.3 435.3 0.0 714.1 0.1 297.2 0.7 386.3 0.3 1160.6 765.7 5.1 2.8 1.8 165.4 0.8 5.0 3.3 16.8 5.2 0.4 1162.6 583.1 1138.4 3.1 1209.3 1.1 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 211.4 188.8 83.4 342.7 229.7 692.7 255.7 205.2 446.7 122.2 150.3 231.2 0.8 0.0 3.1 29.0 2.1 1.7 1.1 1.5 1.2 25.6 0.3 0.6 3.1 0.0 3.5 115.8 8.4 3.6 0.0 0.1 258.2 4.3 3.5 0.9 9.8 3.9 4.2 0.8 147.1 0.8 0.8 35.4 1.1 0.5 2.5 46.3 8.9 0.6 4.7 146.4 118.4 0.0 4.1 0.6 3.4 6.0 37.0 2.3 3.6 35.6 0.6 21.6 0.0 55.8 54.6 3.0 0.0 17.3 9.2 3.7 0.0 17.1 7.4 61.3 0.0 3.6 35.7 10.4 88.4 0.3 1.6 1.5 1.3 20.0 0.2 1.0 UGDH ENSG00000109814 "UDP-glucose 6-dehydrogenase" O60701 4 39498755-39528311 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Carbohydrate metabolism" "Allosteric enzyme, Oxidoreductase" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 137.7" "Cell type enhanced" "Detected in all" "Exocrine glandular cells: 345.5;Hepatocytes: 231.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "A549: 509.6;Hep G2: 595.9;U-2197: 375.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034444, HPA036656, HPA036657" Enhanced Supported Nucleoplasm Yes No 1300000 "Cluster 46: Basophils - DNA binding" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 1: Pancreatic cells - Digestion" Nucleoplasm "CAB034444: AB_2019602, HPA036656: AB_10671706, HPA036657: AB_10672360" "unprognostic (1.22e-2)" "unprognostic (1.62e-1)" "unprognostic (2.73e-2)" "unprognostic (3.96e-2)" "unprognostic (5.54e-2)" "unprognostic (1.63e-1)" "unprognostic (8.78e-3)" "unprognostic (6.07e-2)" "unprognostic (1.34e-1)" "unprognostic (1.41e-1)" "unprognostic (9.81e-3)" "unprognostic (6.86e-2)" "prognostic unfavorable (5.51e-10)" "unprognostic (2.48e-1)" "unprognostic (2.04e-1)" "unprognostic (1.66e-1)" "unprognostic (4.97e-2)" 48.5 27.8 6.2 29.5 7.3 2.4 32.0 9.4 9.2 31.5 18.1 96.5 45.3 29.1 10.6 34.1 29.6 40.5 16.0 5.9 8.3 37.5 137.7 19.0 13.3 7.4 7.7 30.0 33.7 23.1 7.8 38.4 8.0 35.6 73.3 14.3 16.8 14.0 6.7 9.9 41.1 23.5 7.6 11.5 47.4 6.8 8.4 10.3 27.8 9.5 14.5 54.4 17.1 9.7 36.0 509.6 58.4 76.2 181.5 185.3 51.3 102.7 113.8 94.5 84.8 76.2 115.5 25.4 63.0 133.3 94.5 33.5 56.0 29.5 95.8 32.1 13.0 26.2 65.4 595.9 72.7 34.1 25.3 64.4 14.9 160.2 49.8 78.9 59.3 20.9 34.1 17.3 67.9 89.8 29.4 34.4 53.1 194.0 46.4 48.3 95.0 22.0 53.7 120.0 31.2 46.7 69.2 37.9 45.3 41.4 21.0 27.0 85.9 97.9 49.1 375.8 54.2 42.1 33.3 23.3 86.9 25.8 56.6 30.0 20.9 19.7 23.2 18.4 37.8 18.8 18.8 24.9 19.0 18.4 16.1 19.4 3.8 42.3 11.2 22.5 13.5 18.8 6.2 7.3 9.4 9.2 5.9 8.3 7.4 7.7 8.0 7.6 8.4 9.7 19.1 25.6 27.6 4.6 14.1 116.1 73.4 19.5 43.9 7.5 115.8 62.0 8.9 24.3 25.4 20.2 14.6 21.3 12.9 207.8 70.5 54.7 1.1 78.3 53.8 25.4 113.3 9.1 10.6 345.5 78.8 145.7 184.0 64.8 35.5 11.1 20.7 231.3 17.8 10.1 12.6 114.5 12.2 20.2 33.3 1.6 33.2 12.7 30.2 7.5 19.9 7.3 9.2 46.3 12.8 195.8 112.2 29.0 21.3 127.3 81.4 79.6 65.7 9.2 32.9 39.0 57.5 6.5 5.5 102.2 40.1 29.0 11.7 12.4 152.4 86.4 UGP2 "SVUGP2, UGP1, UGPP1" ENSG00000169764 "UDP-glucose pyrophosphorylase 2" Q16851 2 63840952-63891562 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Nucleotidyltransferase, Transferase" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 858.6;tongue: 756.1" "Cell type enhanced" "Detected in all" "Distal enterocytes: 849.9;Hepatocytes: 559.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 417.1" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034696, HPA034697, HPA064836" Enhanced Approved Nucleoplasm,Centrosome,Mitochondria NA NA 13000000 "Cluster 38: Basophils - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 30: Mammary glandular cells - Lactation" "Centrosome, Mitochondria" Nucleoplasm "HPA034696: AB_10670171, HPA034697: AB_2674287, HPA064836: AB_2685365" "unprognostic (1.00e-2)" "unprognostic (6.93e-2)" "unprognostic (5.12e-2)" "unprognostic (1.06e-1)" "unprognostic (2.65e-2)" "unprognostic (1.91e-1)" "prognostic favorable (2.50e-5)" "unprognostic (2.20e-1)" "unprognostic (3.01e-1)" "unprognostic (1.84e-1)" "unprognostic (1.57e-2)" "unprognostic (8.31e-2)" "unprognostic (1.03e-1)" "unprognostic (1.25e-2)" "unprognostic (3.93e-2)" "unprognostic (3.81e-1)" "unprognostic (8.44e-2)" 267.3 72.0 79.8 65.8 89.3 40.1 119.7 72.7 109.8 65.9 78.8 177.9 66.0 75.2 50.6 97.5 68.9 60.7 232.5 87.9 81.4 105.4 858.6 65.4 65.7 77.7 77.0 47.0 74.4 113.3 49.8 137.8 77.6 57.4 159.3 36.8 92.9 66.2 498.0 59.1 67.6 78.5 73.2 50.8 69.5 38.3 83.3 106.2 64.5 756.1 73.7 88.4 63.7 91.8 122.3 77.6 63.1 42.0 176.1 222.4 220.6 129.1 116.1 82.7 89.4 170.0 104.5 149.5 48.3 165.6 79.9 57.4 73.4 102.6 137.0 99.2 35.7 86.5 50.4 117.9 87.0 79.1 73.9 148.1 175.8 76.1 80.3 108.4 119.4 38.9 48.2 58.1 327.8 56.7 104.6 75.2 122.9 207.7 50.1 80.4 117.9 84.5 147.4 77.7 36.5 29.6 103.3 149.8 64.3 162.6 51.7 59.2 144.3 84.4 125.9 113.8 90.5 101.3 51.4 174.9 99.2 122.7 225.7 417.1 33.0 53.1 48.0 40.7 51.8 33.0 53.6 50.1 27.9 31.8 57.6 53.6 45.4 70.0 39.5 29.7 127.2 62.0 79.8 89.3 72.7 109.8 87.9 81.4 77.7 77.0 77.6 73.2 83.3 91.8 73.4 28.9 54.0 107.4 65.3 75.8 87.8 245.9 34.7 49.6 360.6 87.1 264.3 104.4 171.6 47.8 64.6 414.3 81.1 849.9 242.6 140.6 91.5 53.0 106.3 69.8 44.5 56.0 86.1 103.6 445.5 159.3 79.0 49.5 67.8 42.4 63.5 559.4 120.9 87.5 78.4 179.8 144.5 102.4 90.2 86.1 79.2 89.1 96.0 62.8 139.7 58.8 154.5 37.2 79.3 91.6 313.9 77.5 60.7 81.2 176.2 284.4 139.3 57.3 72.3 50.5 129.2 84.9 54.9 50.9 57.8 472.8 143.1 90.6 189.5 109.1 UNC45B "CMYA4, UNC45" ENSG00000141161 "Unc-45 myosin chaperone B" Q8IWX7 17 35147817-35189345 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Differentiation, Myogenesis" "Chaperone, Developmental protein" "Cataract, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 59 "heart muscle: 100.3;skeletal muscle: 196.6;tongue: 151.9" "Group enriched" "Detected in some" 5 "Cardiomyocytes: 201.8;Late spermatids: 59.4" "Group enriched" "Detected in some" 5 "head and neck cancer: 0.9;testis cancer: 1.0" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "gdT-cell: 1.1" "Lineage enriched" "Detected in single" 9 "T-cells: 1.1" "Group enriched" "Detected in some" 11 "BEWO: 1.7;HSkMC: 2.5" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA017861 Approved Cytosol NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 28: BEWO - Transcription regulation" "Cluster 54: Cardiomyocytes - Muscle contraction" Cytosol "HPA017861: AB_1847012" "unprognostic (7.17e-2)" "unprognostic (6.47e-3)" "unprognostic (9.36e-3)" "unprognostic (2.93e-1)" "unprognostic (1.49e-3)" "unprognostic (5.30e-2)" "unprognostic (3.07e-1)" "unprognostic (1.09e-2)" "unprognostic (5.46e-2)" "unprognostic (2.40e-2)" "unprognostic (8.46e-2)" "unprognostic (6.73e-2)" "unprognostic (1.13e-6)" "unprognostic (6.77e-2)" "unprognostic (5.05e-3)" "unprognostic (2.20e-1)" "unprognostic (2.21e-1)" 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.2 0.3 0.0 0.1 0.0 0.0 0.0 0.0 2.1 0.0 0.1 100.3 0.2 0.1 0.1 0.0 0.7 0.2 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.1 2.1 0.0 0.0 2.5 0.0 196.6 0.1 0.0 0.1 0.1 1.4 0.4 1.3 0.1 0.4 0.0 151.9 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.1 0.0 0.9 0.0 0.2 0.5 0.0 0.0 0.1 0.6 0.0 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.2 0.3 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.3 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 201.8 0.0 0.0 0.0 0.0 0.0 0.2 0.0 1.9 0.0 24.6 0.0 0.0 2.3 0.0 2.7 0.4 0.0 0.5 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.4 59.4 0.6 0.1 0.0 1.9 0.0 0.0 1.0 0.5 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 6.3 4.5 0.2 0.7 0.0 0.1 0.0 1.1 0.5 0.0 0.1 USH1C "AIE-75, DFNB18, harmonin, NY-CO-37, NY-CO-38, PDZ-73, PDZ73, PDZD7C" ENSG00000006611 "USH1 protein network component harmonin" Q9Y6N9 11 17493895-17544416 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "Differentiation, Hearing" "Cancer-related genes, Deafness, Non-syndromic deafness, Retinitis pigmentosa, Usher syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 97.8;kidney: 54.0" "Cell type enhanced" "Detected in many" "Distal enterocytes: 190.0;Muller glia cells: 163.6;Paneth cells: 203.0;Proximal enterocytes: 430.7;Proximal tubular cells: 190.3;Undifferentiated cells: 115.7" "Group enriched" "Detected in many" 7 "colorectal cancer: 34.5;pancreatic cancer: 18.8;renal cancer: 29.4;stomach cancer: 15.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "CACO-2: 60.6;HeLa: 21.8;OE19: 57.0" "Not detected" "Not detected" "Low region specificity" "Detected in single" "CAB013690, HPA027398, HPA027492, HPA028033" Enhanced Enhanced Cytosol No NA "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 21: OE19 - Mitochondria" "Cluster 45: Enterocytes - Digestion" Cytosol "CAB013690: , HPA027398: AB_10601775, HPA027492: AB_10601898, HPA028033: AB_10601782" "unprognostic (3.60e-2)" "unprognostic (6.19e-2)" "unprognostic (2.36e-1)" "unprognostic (3.83e-2)" "unprognostic (1.98e-1)" "unprognostic (2.10e-1)" "prognostic unfavorable (2.20e-4)" "unprognostic (2.22e-1)" "unprognostic (2.78e-1)" "unprognostic (1.51e-2)" "unprognostic (9.65e-2)" "prognostic favorable (9.41e-4)" "unprognostic (1.29e-2)" "unprognostic (1.88e-1)" "unprognostic (1.62e-1)" "unprognostic (2.61e-1)" 0.4 0.3 2.8 5.9 6.8 0.0 0.2 2.8 3.9 0.1 1.5 51.5 97.8 0.1 0.3 0.0 2.9 25.9 0.1 9.0 4.7 54.0 0.6 0.1 0.1 6.1 5.7 0.0 3.9 0.0 6.7 0.0 7.0 0.0 48.3 19.0 0.0 0.3 0.0 0.0 96.5 2.1 4.1 0.0 26.7 0.2 5.9 0.1 1.1 0.0 0.0 0.6 0.1 8.3 0.0 1.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 60.6 8.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 21.8 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 57.0 0.0 0.0 0.0 0.4 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 6.8 2.8 3.9 9.0 4.7 6.1 5.7 7.0 4.1 5.9 8.3 0.0 0.0 0.0 18.3 1.6 0.0 0.1 0.0 0.0 0.7 0.0 1.3 0.6 52.9 0.7 5.5 2.1 0.0 0.0 190.0 21.5 20.5 1.0 1.7 0.0 0.4 64.0 0.0 0.6 27.5 0.0 0.3 53.5 0.0 4.5 0.0 0.0 0.0 0.0 1.7 0.2 92.9 0.0 0.0 0.0 0.1 0.0 0.8 0.0 0.0 0.0 163.6 0.0 0.5 36.4 56.0 203.0 0.0 0.2 0.0 430.7 190.3 1.0 4.9 0.0 0.0 0.1 0.1 1.3 0.0 0.0 0.0 0.8 0.1 115.7 0.1 USH1G "ANKS4A, FLJ33924, Sans" ENSG00000182040 "USH1 protein network component sans" Q495M9 17 74916083-74923256 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Hearing "Deafness, Disease variant, Retinitis pigmentosa, Usher syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "esophagus: 7.8;skin 1: 2.8" "Group enriched" "Detected in some" 5 "Early spermatids: 8.2;Late spermatids: 17.9;Muller glia cells: 11.8" "Cancer enhanced" "Detected in some" "head and neck cancer: 2.6" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HaCaT: 1.8;hTCEpi: 1.6;K-562: 1.3;MCF7: 2.0;OE19: 1.9" "Region enriched" "Detected in single" 12 "olfactory bulb: 9.9" "Not detected" "Not detected" HPA024360 Uncertain NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 21: OE19 - Mitochondria" "Cluster 25: Spermatids - Spermatogenesis" "HPA024360: AB_1858660" "unprognostic (2.95e-1)" "unprognostic (6.17e-2)" "unprognostic (6.34e-4)" "unprognostic (2.92e-2)" "unprognostic (8.74e-2)" "unprognostic (1.74e-1)" "unprognostic (5.59e-4)" "unprognostic (1.60e-1)" "unprognostic (1.39e-1)" "unprognostic (8.64e-2)" "unprognostic (1.69e-1)" "unprognostic (2.11e-1)" "unprognostic (3.10e-4)" "unprognostic (1.57e-1)" "unprognostic (8.48e-2)" "unprognostic (2.25e-1)" "unprognostic (3.35e-2)" 0.0 0.9 0.2 0.0 0.2 0.1 0.0 1.2 0.2 0.3 0.0 0.0 0.1 0.8 1.9 7.8 0.1 0.0 0.0 0.1 0.3 0.1 0.0 0.0 0.0 0.1 0.1 0.5 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.8 0.5 0.0 0.0 2.8 0.2 0.5 0.0 0.0 0.0 1.8 0.6 0.1 0.0 0.0 0.1 0.1 0.6 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 1.8 0.4 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 1.6 0.0 0.0 0.0 0.0 0.0 1.3 0.1 0.0 2.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 1.2 0.2 0.1 0.3 0.1 0.1 0.1 0.0 0.6 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.8 0.0 0.0 0.0 0.0 0.7 0.0 0.2 0.0 0.0 0.1 0.0 0.1 0.0 0.0 8.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 17.9 0.3 0.0 0.0 0.0 0.0 11.8 0.0 0.0 0.0 0.0 2.3 0.4 0.0 0.0 1.7 0.6 0.0 0.2 0.0 0.0 0.1 0.2 0.4 1.6 0.3 0.3 0.0 0.1 0.0 0.1 USH2A "RP39, USH2" ENSG00000042781 Usherin O75445 1 215622891-216423448 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Hearing, Sensory transduction, Vision" "Deafness, Disease variant, Retinitis pigmentosa, Usher syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 22 "liver: 7.0;retina: 19.2" "Cell type enhanced" "Detected in some" "Cone photoreceptor cells: 202.3;Early spermatids: 49.3;Rod photoreceptor cells: 165.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Intracellular and membrane" NA NA "Cluster 77: Retina - Visual perception" "Cluster 9: Photoreceptor cells - Phototransduction" "unprognostic (3.92e-3)" "unprognostic (1.74e-1)" "unprognostic (2.97e-2)" "unprognostic (5.38e-2)" "unprognostic (9.19e-2)" "unprognostic (2.04e-1)" "unprognostic (6.62e-4)" "unprognostic (1.00e-1)" "unprognostic (3.68e-1)" "unprognostic (2.06e-1)" "unprognostic (6.07e-3)" "unprognostic (3.15e-2)" "unprognostic (3.28e-11)" "unprognostic (2.02e-2)" "unprognostic (1.91e-1)" "unprognostic (3.35e-2)" "unprognostic (9.09e-4)" 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.1 0.4 0.0 0.2 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.2 0.1 0.2 0.1 7.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 19.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.4 0.1 0.2 0.1 0.2 0.1 0.0 0.2 0.1 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 5.6 0.0 0.0 5.0 1.5 0.0 0.0 202.3 0.0 0.0 0.0 0.0 0.0 49.3 0.3 0.0 0.6 0.0 0.0 17.4 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 12.3 0.0 3.3 10.4 0.0 0.0 0.0 0.0 10.5 0.0 0.0 0.0 0.0 0.0 6.1 0.0 3.0 3.2 0.0 0.0 0.4 0.0 0.0 0.0 0.1 0.2 165.8 0.0 0.2 0.2 1.1 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 USP45 MGC14793 ENSG00000123552 "Ubiquitin specific peptidase 45" Q70EL2 6 99432325-99521728 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease variant, Leber congenital amaurosis" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 7 "brain: 53.5" "Cell type enhanced" "Detected in many" "Excitatory neurons: 47.1;Inhibitory neurons: 44.4;Oligodendrocytes: 39.4" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in all" 6 "cerebellum: 53.5" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029602, HPA029604" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 1: K-562 - Erythropoiesis" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoplasm, Cytosol" "HPA029602: AB_10600418, HPA029604: AB_10602283" "unprognostic (7.81e-3)" "unprognostic (3.10e-3)" "unprognostic (1.63e-2)" "unprognostic (6.62e-2)" "unprognostic (1.02e-2)" "unprognostic (1.92e-1)" "unprognostic (2.15e-2)" "unprognostic (1.01e-1)" "unprognostic (2.77e-2)" "unprognostic (8.65e-2)" "unprognostic (2.95e-3)" "unprognostic (1.10e-1)" "unprognostic (3.43e-3)" "unprognostic (1.13e-1)" "unprognostic (3.53e-1)" "unprognostic (1.43e-1)" "unprognostic (6.91e-2)" 6.1 4.4 5.2 4.9 5.8 4.4 4.6 53.5 9.4 4.3 3.8 5.3 7.3 5.1 4.8 5.3 4.0 6.2 6.2 5.8 6.3 6.3 4.2 3.7 7.4 6.0 7.7 4.5 4.0 4.5 3.6 5.2 8.2 5.1 6.7 6.7 4.0 4.2 6.0 6.3 5.8 4.5 5.3 4.6 4.4 3.3 6.2 3.1 5.3 5.5 5.2 4.3 3.8 9.0 5.9 4.0 8.1 11.2 14.3 13.5 8.7 10.3 11.1 10.1 14.7 8.2 6.4 15.2 7.3 10.3 11.9 7.7 12.1 9.8 13.9 12.2 12.0 15.2 8.4 6.7 11.4 14.2 8.3 15.3 7.6 9.2 15.5 10.7 15.4 13.8 37.2 14.8 9.6 5.5 4.5 13.3 12.8 9.1 8.9 6.8 5.9 8.9 13.8 6.8 11.3 9.2 7.0 9.1 7.8 10.0 4.9 6.8 15.5 5.5 7.1 8.1 15.5 6.3 6.2 29.1 9.8 13.1 10.1 2.9 1.4 0.4 3.2 0.8 4.2 5.3 2.7 4.0 2.4 6.7 1.9 1.9 0.3 1.9 2.0 3.6 2.6 1.0 5.2 5.8 53.5 9.4 5.8 6.3 6.0 7.7 8.2 5.3 6.2 9.0 13.3 3.2 5.8 22.5 13.3 2.3 9.6 6.8 4.6 10.3 4.4 4.6 9.4 4.3 4.7 3.7 18.8 6.4 7.3 5.9 5.9 4.3 15.7 10.1 10.3 7.6 2.4 4.2 47.1 2.5 6.6 7.1 9.7 4.3 2.5 5.8 6.8 4.5 4.0 10.1 44.4 2.9 10.2 4.8 2.6 10.2 13.1 4.6 3.6 22.5 10.0 5.4 2.1 32.6 39.4 5.0 3.1 8.6 6.5 8.6 8.3 15.8 10.4 7.4 0.0 6.3 6.7 1.9 7.5 5.2 2.8 7.4 7.1 5.8 7.3 6.9 VAMP1 "SYB1, VAMP-1" ENSG00000139190 "Vesicle associated membrane protein 1" P23763 12 6462237-6470677 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters" "Congenital myasthenic syndrome, Disease variant, FDA approved drug targets, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 192.8" "Cell type enhanced" "Detected in many" "Bipolar cells: 20.0;Excitatory neurons: 22.6;Inhibitory neurons: 25.0;Oligodendrocytes: 26.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 5 "U-698: 200.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002779, CAB016119, CAB079000" Approved Supported NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB002779: , CAB016119: AB_628309, CAB079000: " "unprognostic (2.33e-1)" "unprognostic (6.72e-3)" "prognostic unfavorable (6.37e-5)" "unprognostic (8.09e-3)" "unprognostic (2.17e-1)" "unprognostic (1.14e-3)" "prognostic unfavorable (6.97e-4)" "unprognostic (1.22e-2)" "unprognostic (6.33e-2)" "unprognostic (1.05e-1)" "unprognostic (1.40e-3)" "unprognostic (3.48e-2)" "prognostic unfavorable (1.04e-11)" "unprognostic (1.47e-2)" "unprognostic (5.99e-2)" "unprognostic (1.62e-1)" "unprognostic (3.65e-2)" 11.7 18.9 45.3 21.9 60.6 63.4 11.5 102.1 179.8 19.6 30.6 35.4 6.9 20.9 7.0 12.5 22.4 6.4 11.5 40.1 85.4 16.1 18.6 15.2 39.7 192.8 89.2 12.7 10.4 2.7 12.8 3.3 163.5 24.1 11.9 35.7 14.5 9.9 10.0 8.9 33.0 10.3 93.3 42.2 17.5 11.4 106.3 12.8 30.8 3.5 35.9 21.4 18.5 93.9 3.0 11.0 5.8 8.1 16.7 19.1 7.1 5.4 10.5 5.7 16.0 3.9 9.5 30.8 1.1 13.5 5.8 8.9 7.2 3.0 8.3 24.3 15.5 4.9 40.1 4.0 7.6 11.6 11.8 13.7 1.4 7.4 4.2 19.5 5.2 13.4 1.9 8.9 13.0 3.4 15.6 13.9 27.4 1.4 4.7 17.5 9.2 5.6 3.5 4.4 1.2 2.3 10.5 6.0 4.5 30.9 2.0 4.6 6.5 2.8 8.5 5.8 3.9 7.6 3.1 200.3 10.2 24.4 2.3 9.0 1.0 14.1 5.9 0.4 4.8 4.8 4.9 5.7 1.1 1.0 5.1 4.4 5.1 2.2 0.5 2.2 6.8 2.3 45.3 60.6 102.1 179.8 40.1 85.4 192.8 89.2 163.5 93.3 106.3 93.9 2.8 6.4 2.0 11.1 10.3 1.1 3.3 1.6 9.1 20.0 2.2 5.0 1.9 1.5 1.9 0.0 6.2 0.3 17.8 4.1 1.9 0.2 0.9 3.3 1.2 2.9 4.8 1.3 22.6 0.5 0.7 3.5 5.1 1.6 10.8 2.6 2.2 3.1 1.7 1.7 25.0 2.1 8.2 3.8 2.6 0.5 3.7 3.6 0.0 6.5 6.0 6.4 10.3 6.6 26.8 0.6 2.8 4.9 12.2 1.8 0.6 0.4 4.9 6.8 6.6 4.7 4.2 2.7 4.3 3.0 0.9 0.1 14.8 2.9 1.6 0.9 VAPB "ALS8, VAP-B, VAP-C" ENSG00000124164 "VAMP associated protein B and C" O95292 20 58389229-58451101 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Host-virus interaction, Unfolded protein response" "Amyotrophic lateral sclerosis, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA013144, CAB013722" Supported Enhanced "Endoplasmic reticulum" NA NA 240000 "Cluster 32: T-cells - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 38: Extravillous trophoblasts - Unknown function" "Endoplasmic reticulum" "CAB013722: , HPA013144: AB_1858717" "unprognostic (3.28e-3)" "unprognostic (3.88e-2)" "unprognostic (1.02e-1)" "unprognostic (2.51e-2)" "unprognostic (9.36e-2)" "unprognostic (3.15e-2)" "unprognostic (4.76e-3)" "unprognostic (2.80e-1)" "unprognostic (4.47e-2)" "unprognostic (8.06e-3)" "unprognostic (3.11e-2)" "unprognostic (2.99e-1)" "prognostic favorable (1.08e-8)" "unprognostic (1.05e-1)" "unprognostic (5.31e-1)" "unprognostic (6.34e-3)" "unprognostic (2.99e-2)" 15.7 36.4 32.1 11.2 30.4 4.2 14.2 29.6 30.1 13.7 20.3 24.2 19.6 16.4 10.3 19.3 14.9 9.7 29.4 28.8 33.5 24.8 35.0 14.1 9.6 34.6 34.0 17.9 18.9 27.9 21.0 9.2 36.2 17.8 9.9 14.3 16.2 12.3 46.4 13.0 18.2 11.6 36.4 15.0 19.0 8.8 37.0 12.2 23.3 39.6 6.7 18.1 12.9 31.5 31.0 30.4 33.6 18.0 30.3 12.5 29.5 27.0 11.2 41.0 20.1 123.0 29.0 27.2 37.7 18.3 32.3 57.6 27.1 38.9 24.6 12.8 20.2 16.5 32.2 38.9 30.2 15.5 19.8 28.9 44.4 22.8 18.7 19.8 20.5 26.7 39.5 14.9 20.0 96.7 24.5 30.6 17.7 60.2 40.0 24.2 31.3 18.0 31.6 40.7 47.1 32.6 44.7 117.0 48.0 18.4 48.0 23.2 28.6 65.8 31.9 33.3 36.9 19.9 23.1 31.4 55.7 16.8 33.8 2.1 2.3 3.1 3.9 2.4 4.5 2.8 4.6 3.2 2.3 2.3 3.3 4.8 3.7 3.7 3.0 2.3 2.7 2.6 32.1 30.4 29.6 30.1 28.8 33.5 34.6 34.0 36.2 36.4 37.0 31.5 22.5 44.8 26.8 31.6 18.7 11.7 13.5 17.2 23.9 29.7 23.6 21.1 46.5 24.3 16.6 31.3 29.2 34.8 20.7 28.6 35.2 35.1 5.0 18.2 20.9 23.2 21.7 18.7 34.3 30.5 50.3 24.0 20.4 16.0 9.5 23.3 15.7 40.3 16.1 35.3 34.7 23.4 22.4 18.5 10.0 6.1 18.6 17.3 14.2 40.3 22.8 34.3 20.6 35.2 43.7 37.5 22.4 25.2 14.0 17.7 38.9 42.9 19.1 29.7 13.1 22.2 26.0 22.0 29.4 18.2 10.5 44.5 20.5 37.4 27.6 16.6 VCAN "CSPG2, PG-M" ENSG00000038427 Versican P13611 5 83471618-83582303 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" Cataract "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 975.7;Granulosa cells: 1131.8;Kupffer cells: 547.3;Macrophages: 605.6;monocytes: 948.1;Oligodendrocyte precursor cells: 1644.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "classical monocyte: 240.0;myeloid DC: 88.9" "Group enriched" "Detected in many" 20 "dendritic cells: 88.9;monocytes: 240.0" "Cell line enhanced" "Detected in many" "AF22: 300.5;HSkMC: 199.5;hTERT-RPE1: 959.0;RPTEC TERT1: 381.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004726, CAB008979" Supported Approved Vesicles "Secreted to blood" NA NA 12000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 57: Non-specific - Angiogenesis" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Vesicles "CAB008979: , HPA004726: AB_1080561" "unprognostic (7.90e-2)" "unprognostic (9.03e-3)" "unprognostic (7.09e-2)" "unprognostic (6.06e-3)" "unprognostic (1.87e-1)" "unprognostic (4.49e-2)" "unprognostic (1.23e-2)" "unprognostic (1.17e-2)" "prognostic unfavorable (7.59e-4)" "unprognostic (4.36e-3)" "unprognostic (2.68e-3)" "unprognostic (2.05e-1)" "prognostic unfavorable (5.17e-4)" "prognostic unfavorable (1.41e-4)" "unprognostic (1.15e-1)" "unprognostic (4.44e-2)" "unprognostic (5.30e-3)" 42.0 23.9 18.6 74.9 20.8 32.6 15.6 24.2 23.0 29.4 5.2 11.3 3.8 17.8 1.8 3.8 8.6 30.5 45.0 25.7 27.8 6.5 2.7 34.4 2.3 36.1 19.3 2.1 3.1 2.4 2.1 73.5 31.3 6.8 10.7 0.2 7.6 4.2 3.9 11.2 5.7 48.0 28.9 13.9 7.7 4.8 44.9 2.7 6.6 6.8 1.9 48.3 7.2 42.7 0.2 5.6 300.5 0.1 119.8 81.5 0.1 2.3 6.2 2.1 1.5 3.1 0.2 0.0 45.2 111.5 3.9 0.0 0.4 0.4 1.7 0.1 9.8 2.1 0.0 2.3 5.5 0.1 0.0 199.5 0.1 127.6 1.2 959.0 0.1 0.0 0.0 0.1 64.6 0.0 0.5 0.0 51.1 0.0 10.3 0.0 63.0 0.1 381.0 0.0 3.6 15.5 0.0 0.0 0.2 33.2 0.2 0.5 116.5 90.6 0.5 168.3 179.0 0.0 0.1 0.2 41.8 0.1 16.4 8.3 240.0 0.5 0.5 31.3 0.3 0.2 0.1 0.1 88.9 0.1 0.1 0.0 3.9 0.5 3.5 1.7 0.0 94.0 18.6 20.8 24.2 23.0 25.7 27.8 36.1 19.3 31.3 28.9 44.9 42.7 23.4 19.2 19.8 128.9 5.5 38.6 10.6 14.9 1.2 0.0 1.8 1.9 8.2 44.3 17.5 25.8 0.0 5.9 7.4 0.0 0.0 1.9 3.0 64.4 975.7 29.9 0.0 5.2 1.5 0.7 7.0 348.1 3.6 241.3 12.6 1131.8 16.8 3.6 25.6 0.0 30.7 0.2 0.0 547.3 83.1 2.5 18.6 605.6 44.4 20.6 948.1 0.0 13.4 1644.7 1.5 32.3 1.1 117.8 2.5 2.5 0.0 1.8 16.2 0.0 0.0 11.0 80.6 0.9 1.2 1.1 28.7 11.5 12.7 1.6 0.3 0.9 VCP "CDC48, IBMPFD, p97, TERA" ENSG00000165280 "Valosin containing protein" P55072 9 35053928-35072668 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Autophagy, DNA damage, DNA repair, Transport, Ubl conjugation pathway" Hydrolase "Amyotrophic lateral sclerosis, Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 540.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005593, HPA012728, HPA012814" Supported Enhanced Nucleoplasm,Cytosol No No 34000000 "Cluster 46: Basophils - DNA binding" "Cluster 39: Non-specific - Mitochondria" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" "Nucleoplasm, Cytosol" "CAB005593: AB_2214638, HPA012728: AB_1858730, HPA012814: AB_1858729" "unprognostic (1.10e-1)" "unprognostic (2.66e-1)" "unprognostic (8.15e-2)" "prognostic favorable (7.30e-4)" "unprognostic (5.78e-2)" "unprognostic (1.87e-1)" "unprognostic (2.52e-3)" "unprognostic (1.13e-2)" "unprognostic (3.82e-2)" "unprognostic (1.81e-2)" "unprognostic (2.19e-2)" "unprognostic (3.24e-1)" "prognostic favorable (9.63e-7)" "unprognostic (1.83e-2)" "unprognostic (1.16e-1)" "unprognostic (3.93e-1)" "unprognostic (9.11e-2)" 59.8 88.4 56.8 33.7 59.0 52.0 54.2 58.9 58.0 57.8 72.0 51.8 33.8 59.0 51.6 84.9 49.4 35.3 117.5 60.4 66.2 59.1 87.5 57.2 42.5 64.4 62.0 46.1 61.2 65.7 57.3 46.0 68.2 54.5 36.5 26.3 63.2 58.9 176.0 64.0 51.8 42.5 62.3 64.1 62.5 45.1 63.7 59.6 49.7 135.3 53.3 57.9 55.3 69.8 167.6 223.8 124.6 57.5 187.4 135.3 98.3 153.8 215.0 244.1 197.6 160.0 60.1 140.8 137.2 242.9 173.1 69.5 253.1 230.7 227.6 146.2 126.0 95.3 216.5 238.0 146.5 92.4 106.2 148.5 136.4 239.2 115.6 104.4 276.2 56.3 97.6 71.4 219.2 154.7 114.3 234.9 152.2 82.7 219.1 80.7 111.8 72.8 204.1 175.7 65.7 84.1 100.4 81.2 45.1 152.2 71.5 60.3 215.5 77.5 112.5 63.7 118.6 41.9 116.5 104.3 139.5 67.0 105.4 142.0 62.7 75.0 58.8 70.0 62.4 59.2 59.0 65.6 75.3 53.0 42.3 44.4 71.1 67.1 80.4 49.8 91.2 111.8 56.8 59.0 58.9 58.0 60.4 66.2 64.4 62.0 68.2 62.3 63.7 69.8 86.5 80.1 73.7 22.9 124.3 77.0 120.8 147.6 111.5 86.6 66.0 47.2 220.4 47.1 115.1 55.2 118.9 276.8 91.0 111.9 74.3 188.6 43.6 97.8 85.6 127.7 84.2 137.0 27.4 187.5 164.7 109.7 133.5 105.8 62.1 106.2 111.0 126.0 133.1 74.0 27.7 108.3 89.5 57.9 65.6 47.0 83.9 81.5 76.5 16.9 159.6 88.7 54.6 18.6 31.4 247.9 69.0 86.9 267.6 118.3 77.2 113.4 102.5 90.0 138.1 74.1 154.9 144.5 118.7 126.2 90.6 540.6 105.4 129.6 96.4 135.6 VEGFA "VEGF, VEGF-A, VPF" ENSG00000112715 "Vascular endothelial growth factor A" P15692 6 43770184-43786487 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins" "Angiogenesis, Differentiation" "Developmental protein, Growth factor, Heparin-binding, Mitogen" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 349.4;Muller glia cells: 265.8" "Cancer enhanced" "Detected in all" "renal cancer: 79.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "hTERT-RPE1: 398.9;U-87 MG: 628.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005429, CAB039240, HPA069116, CAB069907" Supported "Secreted to blood" NA NA 562000 57000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 41: Macrophages - Immune response" "CAB005429: AB_2212984, CAB039240: , CAB069907: AB_10001947, HPA069116: AB_2686089" "unprognostic (1.12e-1)" "prognostic unfavorable (4.50e-4)" "unprognostic (2.42e-2)" "prognostic unfavorable (2.10e-4)" "unprognostic (4.35e-2)" "unprognostic (1.49e-1)" "prognostic unfavorable (2.34e-5)" "unprognostic (5.10e-2)" "unprognostic (5.27e-3)" "unprognostic (2.30e-2)" "unprognostic (1.40e-1)" "unprognostic (1.00e-2)" "prognostic unfavorable (1.76e-5)" "unprognostic (2.20e-1)" "unprognostic (1.80e-1)" "unprognostic (1.43e-1)" "prognostic favorable (2.73e-4)" 155.8 52.7 17.6 36.5 20.3 45.5 92.4 34.2 28.2 45.2 46.8 32.6 50.9 104.0 10.5 61.3 40.9 80.1 208.3 22.8 25.1 116.9 217.3 94.1 9.3 27.0 38.5 25.0 68.1 105.0 22.3 46.2 26.8 120.3 21.4 229.1 32.1 17.8 221.2 44.2 44.6 57.1 19.6 70.1 63.9 5.3 32.0 5.6 270.9 150.9 9.5 122.3 61.7 24.9 76.5 13.4 12.5 71.8 21.0 32.9 84.2 45.6 81.1 29.7 58.4 43.1 9.9 24.9 35.5 27.7 305.4 30.6 34.0 92.0 52.0 27.4 10.4 19.0 17.8 29.2 220.3 20.8 40.4 58.0 178.6 290.6 286.2 398.9 7.7 21.0 35.7 121.7 109.4 31.3 2.3 28.3 7.9 221.2 19.2 2.3 12.0 60.5 114.8 62.9 22.3 46.8 65.6 44.4 162.0 16.1 17.3 75.1 10.4 122.6 32.9 179.2 76.1 68.8 43.6 49.1 628.6 47.9 43.8 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.6 20.3 34.2 28.2 22.8 25.1 27.0 38.5 26.8 19.6 32.0 24.9 63.6 349.4 84.7 121.5 9.8 70.5 51.2 76.8 60.3 37.8 67.0 57.1 164.7 77.2 85.7 22.0 31.3 1.3 11.6 92.9 1.9 54.7 0.0 38.4 59.1 29.0 27.4 21.3 12.1 40.8 6.3 69.7 124.4 121.2 112.0 111.7 17.5 116.0 13.9 180.0 17.0 71.8 12.2 16.2 199.0 0.3 1.8 144.1 28.4 10.3 11.3 265.8 0.0 124.1 1.8 86.0 47.1 3.4 15.9 119.4 61.9 20.5 11.4 43.9 0.0 42.1 79.1 1.1 1.9 82.0 78.3 7.9 11.4 17.4 51.0 137.5 VIM ENSG00000026025 Vimentin P08670 10 17228241-17237593 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Granulosa cells: 4879.0;Langerhans cells: 4893.1;Leydig cells: 5013.2;Muller glia cells: 8977.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC TERT1: 18287.8;fHDF/TERT166: 10084.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000080, HPA001762, CAB058687" Enhanced Supported "Intermediate filaments" NA NA 35000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 89: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 41: Macrophages - Immune response" "Intermediate filaments" "CAB000080: AB_2304493, CAB058687: AB_2665570, HPA001762: AB_1080568" "unprognostic (1.02e-1)" "unprognostic (2.58e-1)" "unprognostic (2.87e-2)" "prognostic favorable (9.75e-6)" "unprognostic (3.81e-2)" "unprognostic (2.52e-1)" "unprognostic (3.21e-1)" "unprognostic (1.61e-1)" "unprognostic (1.17e-1)" "unprognostic (2.05e-1)" "unprognostic (9.29e-2)" "unprognostic (5.61e-2)" "prognostic unfavorable (8.69e-8)" "unprognostic (1.87e-3)" "unprognostic (7.32e-2)" "unprognostic (1.82e-1)" "unprognostic (9.47e-3)" 3467.6 423.1 349.3 610.6 369.5 1455.5 2362.8 289.1 527.4 1816.3 568.1 923.2 218.4 1226.5 400.0 451.5 1458.7 960.2 1364.3 337.5 404.6 473.6 192.8 1133.2 806.2 667.4 328.2 3690.8 370.0 224.8 574.5 1030.0 443.7 570.0 400.8 731.0 628.5 551.8 363.7 1126.8 674.7 1109.3 414.6 819.9 522.8 251.7 472.7 412.2 1391.1 555.8 744.7 983.5 1366.6 425.5 21.2 1119.0 1981.0 3180.7 6407.4 18287.8 3.0 5238.5 3458.9 3859.2 3421.5 8.5 70.4 2.9 273.2 10084.4 1804.7 8.4 283.8 147.0 3734.1 3567.5 387.2 563.2 523.5 0.3 1967.3 301.1 222.8 6746.8 6.5 5712.0 3213.4 9020.8 6366.3 372.4 889.3 1575.4 6939.5 4.5 736.6 911.2 632.4 1.4 1394.0 564.8 2745.9 95.7 3925.3 0.8 8.1 946.6 1.4 6.9 5447.5 1133.1 8.6 341.8 5459.0 3819.8 1644.5 3244.7 6311.5 1754.4 953.7 130.4 5775.4 28.9 3726.3 667.8 751.8 215.2 219.5 469.3 278.7 176.3 357.0 285.0 866.0 117.5 217.1 217.2 409.3 99.2 471.2 342.3 481.5 615.4 349.3 369.5 289.1 527.4 337.5 404.6 667.4 328.2 443.7 414.6 472.7 425.5 3211.7 157.0 349.4 53.5 605.8 725.8 21.6 361.2 58.1 74.2 108.8 539.1 109.5 94.4 157.3 108.5 50.1 22.1 1110.1 9.1 5.9 198.8 58.1 922.9 2314.1 2923.2 309.1 236.5 0.4 569.0 45.8 3443.0 101.4 693.7 2776.4 4879.0 2195.6 19.2 3541.4 33.7 0.3 1.8 16.2 2841.2 4893.1 131.6 5013.2 3177.8 3082.5 85.3 3893.1 8977.0 259.5 1.0 0.4 525.9 1.5 2336.6 2097.2 79.5 3.1 181.6 90.7 284.1 1420.0 3171.9 3714.2 55.1 27.5 39.4 473.0 52.7 1566.3 1791.1 6.2 28.9 VLDLR "CARMQ1, CHRMQ1, VLDLRCH" ENSG00000147852 "Very low density lipoprotein receptor" P98155 9 2621182-2660056 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Cholesterol metabolism, Endocytosis, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport" Receptor "Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "ovary: 77.5" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 78.1;Cone photoreceptor cells: 104.3;Oligodendrocytes: 39.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 6 "eosinophil: 6.3" "Lineage enriched" "Detected in single" 10 "granulocytes: 6.3" "Cell line enhanced" "Detected in many" "BEWO: 22.3;JURKAT: 20.5;THP-1: 33.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032462, HPA051312" Uncertain Uncertain "Vesicles,Cytokinetic bridge,Centriolar satellite" Yes NA 330000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 72: Non-specific - Transcription" "Cluster 43: THP-1 - Innate immune response" "Cluster 9: Photoreceptor cells - Phototransduction" Vesicles "Cytokinetic bridge, Centriolar satellite" "CAB032462: AB_2216805, HPA051312: " "unprognostic (5.31e-2)" "unprognostic (2.65e-1)" "unprognostic (6.92e-2)" "prognostic favorable (5.95e-4)" "unprognostic (1.15e-1)" "unprognostic (2.67e-2)" "unprognostic (2.48e-3)" "unprognostic (1.76e-1)" "unprognostic (1.52e-1)" "unprognostic (3.00e-2)" "unprognostic (3.79e-2)" "unprognostic (2.33e-1)" "unprognostic (6.75e-2)" "unprognostic (1.48e-2)" "unprognostic (1.93e-1)" "unprognostic (1.80e-2)" "unprognostic (4.34e-2)" 15.7 16.3 2.7 2.2 6.4 0.8 8.5 5.3 4.2 10.3 6.4 6.6 0.5 9.6 3.2 19.2 13.8 2.9 43.7 3.2 5.3 10.6 3.1 10.7 0.7 7.7 5.6 77.5 27.4 19.5 6.5 5.9 5.9 6.6 2.0 12.3 11.6 2.0 26.2 5.3 1.9 6.8 4.0 5.5 9.0 6.0 4.9 0.8 11.6 11.7 1.7 12.5 10.4 9.8 0.1 0.8 14.3 0.4 1.5 0.5 22.3 7.0 2.2 1.7 4.3 3.6 0.3 0.0 6.4 2.8 0.6 0.3 3.4 5.6 4.5 9.7 2.4 0.1 1.6 1.8 1.9 9.2 1.7 1.5 3.3 0.7 0.1 7.6 0.7 20.5 0.0 17.4 1.1 0.9 1.1 1.1 9.9 1.5 0.9 0.1 0.4 0.0 6.4 0.4 2.5 2.4 0.6 0.6 10.4 7.5 0.3 33.3 0.3 2.8 4.5 0.1 3.3 14.1 6.1 2.6 14.7 8.2 0.6 0.0 0.0 6.3 0.2 0.0 0.6 0.0 0.0 0.2 0.1 0.0 0.0 0.0 1.0 0.0 0.0 0.5 0.0 0.0 2.7 6.4 5.3 4.2 3.2 5.3 7.7 5.6 5.9 4.0 4.9 9.8 4.2 16.0 8.8 1.0 0.1 2.7 1.2 18.7 4.6 23.8 4.3 3.9 78.1 1.5 9.7 5.5 104.3 13.2 1.6 9.8 1.9 11.3 5.7 8.6 6.1 3.6 10.9 0.0 8.3 10.3 29.0 17.2 3.1 19.3 0.0 5.7 2.2 2.8 2.3 11.8 10.9 1.4 24.4 1.0 1.1 2.8 7.8 0.6 10.6 2.8 1.0 3.9 0.0 8.0 39.1 8.6 4.3 10.9 0.5 5.1 0.0 8.0 11.9 32.5 0.0 2.7 9.4 8.2 6.4 5.0 2.0 3.4 1.7 15.9 1.3 6.0 VPS13A "CHAC, KIAA0986" ENSG00000197969 "Vacuolar protein sorting 13 homolog A" Q96RL7 9 77177445-77421537 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters" "Protein transport, Transport" "Disease variant, Epilepsy, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 228.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021652, HPA021662" Supported NA NA "Cluster 6: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA021652: AB_1858759, HPA021662: AB_1858760" "unprognostic (1.52e-1)" "unprognostic (4.19e-2)" "unprognostic (5.49e-3)" "unprognostic (2.96e-1)" "unprognostic (4.68e-1)" "unprognostic (8.54e-2)" "unprognostic (8.91e-3)" "unprognostic (1.69e-3)" "unprognostic (9.67e-2)" "unprognostic (9.74e-2)" "unprognostic (1.14e-1)" "unprognostic (9.96e-2)" "unprognostic (5.63e-2)" "unprognostic (6.53e-2)" "unprognostic (3.28e-1)" "unprognostic (2.05e-1)" "unprognostic (1.70e-2)" 5.1 7.6 2.6 7.1 4.8 17.6 7.3 11.2 9.6 4.4 3.6 9.4 16.3 6.0 8.0 7.6 4.7 9.0 9.5 6.0 0.1 9.9 7.4 6.3 8.8 0.5 0.1 3.6 8.8 9.3 6.5 3.6 0.3 6.7 11.4 7.2 8.0 6.6 14.6 15.6 13.8 7.2 0.0 10.6 12.3 16.8 0.2 10.3 8.5 9.8 7.6 6.4 6.2 3.1 21.0 10.4 9.1 7.9 8.5 7.4 13.7 11.4 10.3 9.8 11.1 4.2 9.3 16.4 5.2 10.6 11.9 27.9 13.7 11.3 17.4 15.5 11.0 21.7 21.3 10.3 8.3 28.3 13.9 4.7 16.6 14.5 17.7 17.3 14.1 15.7 14.3 17.4 6.0 9.8 21.7 9.7 10.2 11.9 8.3 15.7 17.4 6.8 14.1 20.2 13.3 13.3 14.3 9.2 6.3 16.6 6.3 6.3 18.6 10.4 11.3 14.4 14.6 9.7 9.6 8.4 10.8 13.2 4.2 3.8 0.2 2.0 1.2 0.1 1.2 0.9 0.9 0.9 0.1 1.2 0.7 0.8 0.2 1.2 0.1 2.2 0.7 0.2 2.6 4.8 11.2 9.6 6.0 0.1 0.5 0.1 0.3 0.0 0.2 3.1 29.7 64.1 46.5 48.3 32.2 33.0 26.6 28.0 27.3 29.1 25.4 22.1 87.2 27.1 41.2 29.5 58.4 15.2 42.3 78.9 3.9 18.2 90.5 33.8 28.2 38.6 87.8 48.4 228.3 18.4 4.8 18.9 86.6 42.6 19.0 32.4 37.5 34.1 8.6 11.8 101.1 47.4 30.5 10.6 14.4 55.0 13.7 13.3 23.2 43.1 11.9 16.4 41.2 72.4 23.0 46.2 42.9 15.8 42.7 31.0 98.5 21.7 38.9 18.2 32.9 33.1 30.5 74.3 64.5 36.6 31.3 8.9 43.2 38.0 39.8 25.7 VPS13C "FLJ10381, FLJ20136, KIAA1421" ENSG00000129003 "Vacuolar protein sorting 13 homolog C" Q709C8 15 61852389-62060473 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Inhibitory neurons: 272.2;Oligodendrocytes: 291.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043507 Uncertain Approved Microtubules NA NA "Cluster 6: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 32: U-937 - Innate immune response" "Cluster 52: Non-specific - Transcription" Microtubules "HPA043507: AB_10960840" "unprognostic (1.09e-2)" "unprognostic (5.42e-2)" "unprognostic (1.07e-1)" "unprognostic (1.94e-2)" "unprognostic (5.90e-2)" "unprognostic (2.31e-2)" "unprognostic (3.92e-1)" "unprognostic (3.18e-2)" "unprognostic (2.15e-1)" "unprognostic (1.48e-1)" "unprognostic (3.61e-1)" "unprognostic (1.79e-1)" "unprognostic (1.17e-2)" "unprognostic (3.92e-2)" "unprognostic (1.03e-1)" "unprognostic (2.01e-1)" "unprognostic (5.58e-3)" 9.3 8.3 6.0 13.3 13.8 10.5 9.6 10.2 8.4 11.7 3.1 8.9 6.8 12.0 7.6 4.1 9.4 9.1 6.7 4.4 6.9 8.9 7.2 10.9 17.7 12.9 8.3 16.9 8.6 12.3 5.5 7.9 15.2 7.9 9.1 18.8 8.0 6.1 7.1 5.7 7.7 9.4 8.3 17.8 12.8 6.1 9.9 14.6 11.5 12.8 15.1 9.1 3.5 24.6 8.2 13.9 5.2 5.5 22.8 20.1 6.1 6.4 25.4 6.2 7.5 5.8 5.3 27.9 7.4 12.5 11.6 9.3 18.8 7.2 5.5 20.1 3.4 28.3 7.9 5.4 11.3 13.7 17.6 14.3 4.8 6.7 13.9 14.0 19.2 28.1 8.9 19.5 9.9 3.5 8.1 5.4 3.4 8.7 3.7 19.0 16.1 7.5 10.5 32.5 7.7 9.4 11.5 6.6 7.0 9.1 7.2 19.9 28.9 14.0 7.8 8.5 8.2 9.8 9.4 16.3 11.1 28.8 6.8 3.7 4.2 2.5 3.3 3.1 2.8 4.9 2.7 2.7 3.0 5.3 3.0 2.5 1.1 2.2 5.4 5.9 2.3 1.2 6.0 13.8 10.2 8.4 4.4 6.9 12.9 8.3 15.2 8.3 9.9 24.6 92.5 67.3 61.6 161.6 108.5 18.6 32.3 33.1 26.7 84.9 41.8 24.5 75.2 25.8 83.2 57.0 146.0 14.8 141.1 16.7 9.8 36.7 6.4 92.9 79.6 57.3 53.0 30.7 182.8 29.6 8.3 56.2 83.1 118.9 89.7 51.8 43.2 22.7 31.3 124.5 272.2 29.9 44.7 71.0 58.1 7.3 50.4 107.2 35.6 148.9 118.5 29.6 84.5 217.1 291.3 26.7 21.0 51.6 83.9 25.2 21.6 12.3 113.1 84.5 32.9 86.5 66.9 20.8 20.4 5.9 23.3 8.2 98.8 88.2 23.9 28.3 VPS13D "FLJ10619, KIAA0453" ENSG00000048707 "Vacuolar protein sorting 13 homolog D" Q5THJ4 1 12230030-12512047 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 181.4;Inhibitory neurons: 149.2;Late spermatids: 208.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027332, HPA051621" Uncertain Approved Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 17: Basophils - Unknown function" "Cluster 27: Brain & Skin - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoplasm, Vesicles" Cytosol "HPA027332: AB_2672223, HPA051621: AB_2681555" "unprognostic (2.97e-1)" "unprognostic (8.47e-2)" "unprognostic (2.89e-2)" "unprognostic (2.84e-2)" "unprognostic (9.74e-2)" "unprognostic (1.75e-2)" "unprognostic (1.66e-1)" "unprognostic (1.53e-3)" "unprognostic (3.33e-1)" "unprognostic (2.00e-2)" "unprognostic (1.57e-1)" "unprognostic (7.77e-2)" "prognostic favorable (7.42e-12)" "unprognostic (5.13e-1)" "unprognostic (1.72e-1)" "unprognostic (4.04e-2)" "unprognostic (8.31e-2)" 10.9 6.9 14.3 4.4 17.2 5.0 10.3 14.5 17.9 13.7 18.1 12.2 3.8 8.1 8.7 12.6 8.9 5.3 21.9 15.8 14.5 10.5 10.4 8.8 6.4 14.6 16.5 8.9 10.9 13.4 7.7 5.3 14.3 17.4 6.4 14.1 10.8 9.3 18.1 24.7 8.7 6.0 13.4 9.3 11.1 6.1 17.8 6.6 15.5 15.3 6.2 9.6 10.6 16.6 9.3 5.2 5.8 4.4 15.1 11.9 2.7 4.4 7.7 7.4 7.0 3.5 6.4 8.7 5.4 12.6 6.2 8.3 10.1 8.7 10.3 4.7 3.4 7.4 8.1 2.8 6.3 10.8 3.7 10.1 11.9 9.5 9.3 9.2 12.0 8.2 15.5 4.3 6.9 4.3 6.4 4.2 2.3 5.0 6.5 5.5 6.9 2.6 5.3 5.4 2.8 3.8 12.9 9.4 9.0 5.4 8.1 3.6 13.1 4.6 4.7 12.0 3.7 3.8 3.3 13.4 5.2 7.5 7.1 3.2 0.7 0.5 1.1 0.7 1.2 0.9 1.2 0.8 0.6 1.6 1.1 0.9 0.9 0.7 0.5 1.5 0.6 0.3 14.3 17.2 14.5 17.9 15.8 14.5 14.6 16.5 14.3 13.4 17.8 16.6 28.9 19.2 23.4 111.0 19.8 21.7 45.1 23.2 19.9 38.1 18.8 12.8 68.0 14.3 35.7 18.4 73.0 8.4 20.3 24.7 3.9 9.1 83.1 20.6 23.5 23.0 14.4 9.4 181.4 14.4 7.2 19.4 28.1 48.1 12.6 26.3 17.9 21.2 11.5 47.1 149.2 15.1 18.3 17.3 15.5 208.7 23.0 17.5 12.4 79.6 16.7 23.0 17.5 78.4 107.4 17.0 11.2 21.8 11.8 32.0 18.2 9.8 32.0 34.1 46.0 23.4 46.5 18.8 12.3 38.2 31.4 14.8 21.4 20.3 15.5 37.3 VPS35 "FLJ10752, MEM3, PARK17" ENSG00000069329 "VPS35 retromer complex component" Q96QK1 16 46656132-46689518 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Host-virus interaction, Protein transport, Transport" "Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040802 Supported Supported Endosomes,Lysosomes NA NA 500000 "Cluster 51: Monocytes - Innate immune response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 30: Epithelial cell lines - Translation" "Cluster 40: Granulosa cells - Unknown function" "Endosomes, Lysosomes" "HPA040802: AB_2677142" "unprognostic (1.11e-2)" "unprognostic (8.70e-2)" "prognostic favorable (7.74e-4)" "unprognostic (4.75e-2)" "unprognostic (1.90e-1)" "unprognostic (5.67e-3)" "prognostic unfavorable (2.10e-6)" "unprognostic (5.32e-2)" "unprognostic (1.49e-1)" "unprognostic (2.29e-2)" "unprognostic (3.33e-3)" "unprognostic (2.49e-1)" "prognostic favorable (9.75e-5)" "unprognostic (3.68e-3)" "unprognostic (2.43e-1)" "unprognostic (1.34e-1)" "unprognostic (6.89e-3)" 5.4 4.2 2.9 3.0 3.0 9.5 4.6 2.6 3.2 4.2 2.8 4.2 1.9 4.3 1.9 4.7 4.0 1.4 6.1 3.0 2.5 3.7 1.7 4.1 2.9 3.0 2.4 4.7 4.4 5.2 3.3 2.1 3.2 3.0 1.8 4.1 4.5 2.4 4.6 6.1 4.9 1.7 2.1 4.2 4.5 2.7 2.8 3.9 2.7 2.7 1.8 4.5 4.2 3.4 3.2 5.0 4.1 2.8 6.5 7.3 2.1 3.8 5.4 6.4 3.7 4.3 2.7 4.2 2.3 6.5 3.3 3.9 7.5 7.5 9.1 1.6 6.4 3.9 3.8 3.0 5.4 5.2 5.8 5.8 5.5 7.3 4.5 6.3 6.6 6.0 3.1 1.8 6.5 2.9 4.0 5.0 1.4 3.0 6.6 5.4 5.4 5.2 5.2 4.4 1.8 2.1 4.1 3.2 1.8 4.5 1.9 2.6 3.9 1.9 1.9 4.3 2.7 2.3 3.2 4.9 3.4 4.0 1.3 1.8 1.3 1.3 0.7 1.7 0.7 0.8 0.7 0.6 1.5 1.0 1.0 0.7 1.5 0.8 2.3 0.6 1.1 1.1 2.9 3.0 2.6 3.2 3.0 2.5 3.0 2.4 3.2 2.1 2.8 3.4 65.9 51.3 59.4 20.5 84.3 72.5 80.0 98.6 72.8 56.5 77.9 75.9 102.9 57.2 83.4 68.0 60.5 134.5 44.9 65.9 54.8 111.7 111.2 136.4 92.3 63.3 80.8 52.6 43.1 72.5 102.2 70.1 88.7 88.4 72.2 211.1 54.7 40.2 123.4 45.4 42.5 79.7 107.8 108.3 87.9 32.4 77.9 113.6 46.2 30.0 153.0 71.4 45.3 28.6 31.3 101.1 101.9 72.2 41.7 77.0 164.6 103.7 188.9 82.6 46.0 57.5 88.9 207.9 118.0 101.5 87.7 113.1 51.5 95.9 97.6 84.5 VPS37A "FLJ32642, HCRP1, PQBP2, SPG53" ENSG00000155975 "VPS37A subunit of ESCRT-I" Q8NEZ2 8 17246931-17302427 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Protein transport, Transport" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA024705, HPA024781" Supported Approved Vesicles,Centrosome,Cytosol NA NA "Cluster 46: Basophils - DNA binding" "Cluster 23: Testis - Cell cycle regulation" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 55: Plasma cells - Humoral immune response" Vesicles "Centrosome, Cytosol" "HPA024705: AB_10601776, HPA024781: AB_10602100" "unprognostic (8.28e-2)" "unprognostic (1.84e-1)" "unprognostic (9.39e-3)" "unprognostic (3.91e-1)" "unprognostic (2.10e-1)" "unprognostic (6.31e-2)" "unprognostic (5.88e-3)" "unprognostic (2.28e-2)" "unprognostic (1.43e-1)" "unprognostic (3.17e-1)" "unprognostic (1.02e-1)" "unprognostic (2.88e-1)" "unprognostic (5.06e-2)" "unprognostic (1.98e-2)" "unprognostic (1.31e-1)" "unprognostic (2.66e-1)" "unprognostic (2.18e-1)" 18.9 19.4 11.9 14.8 15.1 15.4 18.5 28.7 17.5 21.1 5.0 16.8 20.9 19.4 14.3 20.2 13.7 16.8 36.2 10.1 13.6 25.0 27.8 16.2 14.2 11.2 12.5 18.4 17.5 33.8 12.4 29.7 12.1 20.2 17.2 55.0 12.5 23.2 39.4 14.7 17.5 24.4 10.0 12.3 14.5 32.3 12.2 17.5 18.9 31.2 15.2 25.1 15.0 18.4 17.2 27.3 24.0 21.7 51.8 41.5 25.8 60.8 50.2 53.9 45.9 17.6 16.2 14.6 31.6 48.7 50.1 16.7 27.2 26.4 63.8 15.1 7.8 26.5 13.7 20.2 59.7 11.3 25.1 39.7 50.2 50.4 51.5 38.0 38.7 22.7 20.2 36.8 57.7 11.7 32.0 26.9 23.4 38.2 14.2 15.4 26.5 17.6 45.8 23.4 27.1 14.4 23.8 23.9 37.9 47.1 15.6 22.2 33.4 33.1 16.7 47.6 32.0 12.0 25.0 17.2 37.5 19.9 33.8 34.0 17.2 16.5 13.9 13.1 17.1 10.5 13.4 13.6 13.4 10.8 12.0 14.8 17.6 24.5 12.4 11.8 13.3 14.1 11.9 15.1 28.7 17.5 10.1 13.6 11.2 12.5 12.1 10.0 12.2 18.4 31.8 16.0 15.6 19.6 21.2 39.5 32.7 33.1 18.8 26.4 19.3 13.5 40.7 14.3 25.8 7.3 58.4 36.1 20.5 15.8 37.2 29.3 93.2 20.9 29.0 24.6 18.0 26.1 32.4 15.5 59.2 27.0 15.8 28.4 9.5 16.8 24.3 23.1 44.6 21.9 30.7 16.6 30.5 17.5 22.7 39.6 25.7 25.3 21.4 20.6 22.4 25.8 15.5 24.1 34.0 31.2 13.1 25.9 21.5 50.6 27.8 48.8 18.8 60.2 26.3 21.5 36.6 111.6 43.4 22.5 37.8 113.0 22.7 17.1 14.6 52.6 VSX1 "PPCD, PPCD1, PPD" ENSG00000100987 "Visual system homeobox 1" Q9NZR4 20 25070885-25082141 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Sensory transduction, Transcription, Transcription regulation, Vision" "Developmental protein, DNA-binding" "Corneal dystrophy, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 9 "brain: 14.8;retina: 35.5" "Cell type enriched" "Detected in some" 23 "Bipolar cells: 465.9" "Not detected" "Not detected" "Region enriched" "Detected in all" 4 "cerebellum: 14.8" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 5 "Karpas-707: 4.5" "Not detected" "Not detected" "Not detected" "Not detected" HPA079607 Approved Nucleoli NA NA "Cluster 6: Non-specific - Transcription" "Cluster 77: Retina - Visual perception" "Cluster 2: Karpas-707 - Immune response" "Cluster 56: Bipolar cells - Visual perception" Nucleoli "HPA079607: " "unprognostic (1.93e-1)" "unprognostic (6.63e-2)" "unprognostic (9.68e-3)" "unprognostic (4.33e-2)" "unprognostic (2.27e-1)" "unprognostic (1.97e-1)" "unprognostic (4.01e-1)" "unprognostic (8.64e-3)" "unprognostic (2.70e-2)" "unprognostic (1.35e-1)" "unprognostic (2.31e-9)" "unprognostic (1.53e-2)" "unprognostic (2.35e-1)" "unprognostic (3.07e-4)" "unprognostic (2.38e-1)" 0.0 0.9 3.4 0.0 3.3 0.5 0.1 14.8 2.8 0.1 1.7 0.1 0.0 0.3 0.1 0.1 0.1 0.0 0.2 2.9 3.5 0.0 0.2 0.0 0.1 3.2 3.3 1.4 0.4 0.7 2.9 0.0 3.2 0.2 0.1 35.5 0.1 0.3 0.5 0.2 0.1 0.0 3.0 0.1 0.1 0.2 3.4 0.7 0.2 0.2 0.0 0.2 0.0 3.4 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 4.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.4 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.2 0.0 0.3 0.0 0.0 3.4 3.3 14.8 2.8 2.9 3.5 3.2 3.3 3.2 3.0 3.4 3.4 0.0 0.0 0.0 6.5 0.1 0.0 0.0 0.0 0.0 465.9 0.1 0.0 1.0 0.0 0.0 0.0 4.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.6 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 1.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 1.0 0.0 5.3 0.0 19.6 1.8 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 18.9 0.0 0.0 0.0 0.7 1.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 VWA3B "DKFZp686F2227, MGC26733" ENSG00000168658 "Von Willebrand factor A domain containing 3B" Q502W6 2 98087116-98313299 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "fallopian tube: 22.3;testis: 30.0" "Group enriched" "Detected in many" 5 "Early spermatids: 467.1;Late spermatids: 995.9" "Cancer enhanced" "Detected in single" "endometrial cancer: 1.0" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in many" 4 "hippocampal formation: 7.1" "Low region specificity" "Detected in all" "HPA036700, HPA036701" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 49: Ciliated cells - Cilium organization" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Cytosol" "HPA036700: AB_2675261, HPA036701: AB_10673505" "unprognostic (2.36e-2)" "unprognostic (4.27e-2)" "unprognostic (1.23e-1)" "unprognostic (1.01e-3)" "unprognostic (5.16e-2)" "unprognostic (3.27e-1)" "unprognostic (1.33e-1)" "unprognostic (1.11e-1)" "unprognostic (1.74e-1)" "unprognostic (1.44e-2)" "unprognostic (4.53e-2)" "unprognostic (6.41e-2)" "unprognostic (2.63e-7)" "unprognostic (2.57e-1)" "unprognostic (5.04e-2)" "unprognostic (2.27e-1)" "unprognostic (4.96e-2)" 0.0 0.0 1.4 0.0 1.1 0.0 0.0 0.9 0.7 0.6 5.0 0.1 0.0 0.2 0.0 0.0 22.3 0.0 0.0 1.3 1.5 0.1 0.0 2.5 0.0 7.0 5.8 0.2 0.0 0.0 0.2 0.0 3.7 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 4.8 0.0 0.1 30.0 1.2 0.7 0.0 0.1 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 1.1 0.9 0.7 1.3 1.5 7.0 5.8 3.7 4.8 1.2 2.7 0.3 0.0 1.1 11.8 0.1 0.3 1.7 2.2 0.0 1.0 0.1 0.3 0.9 0.0 12.1 1.8 31.3 0.0 0.0 0.8 0.0 0.0 467.1 53.8 0.6 0.6 1.8 0.0 1.9 0.4 0.2 0.8 4.6 1.6 0.0 0.1 1.1 0.0 0.2 0.0 1.0 2.8 6.1 0.0 0.8 995.9 4.7 0.7 0.0 3.7 0.6 0.7 0.0 1.5 0.7 0.2 2.7 5.7 0.2 0.4 0.2 0.0 124.5 0.5 0.0 0.5 1.0 17.6 6.0 0.0 0.4 0.0 0.1 0.2 1.0 0.8 WARS1 "IFI53, IFP53, WARS" ENSG00000140105 "Tryptophanyl-tRNA synthetase 1" P23381 14 100333790-100376805 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Angiogenesis, Protein biosynthesis" "Aminoacyl-tRNA synthetase, Ligase" "Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "placenta: 324.4" "Cell type enhanced" "Detected in some" "Adipocytes: 66.4;Cytotrophoblasts: 16.5;Endothelial cells: 38.5;Hofbauer cells: 43.1;Syncytiotrophoblasts: 16.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "intermediate monocyte: 1345.3;non-classical monocyte: 1608.2" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HHSteC: 908.5;SK-MEL-30: 1012.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005573, HPA018944" Enhanced Enhanced Cytosol No No 49000000 "Cluster 51: Monocytes - Innate immune response" "Cluster 28: Placenta - Pregnancy" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 41: Macrophages - Immune response" Cytosol "HPA005573: AB_2667366, HPA018944: AB_2669986" "unprognostic (5.36e-2)" "unprognostic (5.98e-2)" "unprognostic (3.99e-2)" "unprognostic (1.54e-1)" "unprognostic (2.30e-1)" "unprognostic (9.25e-2)" "prognostic unfavorable (7.88e-4)" "unprognostic (5.14e-2)" "unprognostic (4.26e-2)" "prognostic favorable (1.94e-4)" "unprognostic (4.84e-2)" "unprognostic (3.21e-1)" "unprognostic (3.53e-3)" "unprognostic (1.37e-1)" "unprognostic (9.45e-2)" "unprognostic (1.62e-1)" "unprognostic (5.92e-3)" 100.7 67.9 40.3 185.6 44.4 70.5 65.4 40.1 45.5 35.9 45.2 67.8 44.8 39.6 70.3 54.4 50.8 48.7 157.6 44.2 56.0 83.6 47.9 207.5 139.0 72.0 52.6 21.2 47.5 39.2 63.4 324.4 65.3 49.1 72.0 37.8 49.5 38.3 74.7 28.4 67.7 76.2 47.6 110.6 70.1 67.7 55.0 61.7 159.9 67.0 86.2 107.7 30.7 44.9 91.2 85.7 54.6 319.1 78.7 110.7 87.3 117.4 220.7 232.1 301.4 57.4 80.2 101.7 105.5 277.4 59.7 151.1 158.8 130.3 153.1 154.4 48.3 64.1 60.9 72.3 908.5 184.9 101.6 126.9 186.9 141.3 290.1 74.5 225.0 66.1 202.8 255.0 107.5 178.0 64.3 87.1 55.4 94.1 152.2 51.4 86.5 64.9 119.3 80.8 145.7 84.9 69.4 58.7 1012.4 70.5 153.6 234.7 153.1 25.7 58.9 269.2 61.3 446.4 277.1 191.9 295.0 144.2 205.5 96.5 471.7 610.4 41.5 1345.3 38.4 71.4 34.5 38.4 337.9 68.0 24.8 28.6 170.9 44.5 1608.2 54.7 44.8 672.7 40.3 44.4 40.1 45.5 44.2 56.0 72.0 52.6 65.3 47.6 55.0 44.9 66.4 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.9 0.0 0.0 0.0 0.0 16.5 3.7 0.0 0.0 0.0 0.0 0.0 0.0 38.5 0.0 0.0 0.0 0.0 11.5 5.5 0.0 0.0 0.0 0.0 0.0 0.0 43.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 16.6 0.5 0.0 0.0 0.0 WASHC5 "KIAA0196, SPG8" ENSG00000164961 "WASH complex subunit 5" Q12768 8 125024260-125091819 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Protein transport, Transport" "Disease variant, Hereditary spastic paraplegia, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 19.8;Exocrine glandular cells: 17.2;Hofbauer cells: 21.8;Proximal tubular cells: 17.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034216, CAB034219, HPA064649, HPA070916" Supported Enhanced Nucleoplasm NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 34: Non-specific - Transcription" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "CAB034216: AB_2234159, CAB034219: AB_2130519, HPA064649: AB_2685312, HPA070916: AB_2686322" "unprognostic (1.98e-3)" "unprognostic (3.75e-2)" "unprognostic (8.40e-2)" "unprognostic (3.89e-3)" "unprognostic (2.98e-2)" "unprognostic (1.91e-1)" "prognostic unfavorable (6.74e-5)" "unprognostic (2.54e-2)" "unprognostic (3.54e-1)" "unprognostic (5.69e-2)" "unprognostic (9.10e-3)" "unprognostic (1.53e-1)" "unprognostic (9.39e-3)" "unprognostic (5.95e-2)" "unprognostic (2.17e-1)" "unprognostic (1.62e-1)" "unprognostic (2.33e-2)" 18.1 18.6 10.5 18.5 16.9 21.3 19.6 14.9 13.2 17.2 16.5 18.5 18.1 16.2 15.7 16.6 13.3 17.8 16.1 11.1 12.5 22.9 18.5 17.1 19.6 14.7 13.7 15.6 13.0 24.8 9.5 21.2 14.6 17.4 20.1 11.4 14.3 16.1 15.9 13.6 14.7 20.2 14.0 19.3 16.1 9.5 13.8 21.8 23.3 18.5 21.0 21.1 10.3 24.7 40.0 45.4 24.9 30.6 55.3 58.8 16.3 42.0 63.6 43.0 45.8 17.0 42.1 36.1 29.1 54.1 25.3 30.6 40.2 37.7 56.8 47.5 23.1 48.1 26.5 22.8 53.8 14.8 46.6 58.7 25.1 35.5 31.2 33.2 49.9 30.9 28.3 35.6 53.0 87.6 44.3 11.8 23.7 66.7 46.7 29.8 22.4 36.7 33.2 48.5 13.1 26.3 48.8 109.2 39.5 25.8 47.3 25.5 44.7 23.6 51.9 39.4 37.7 31.7 31.2 31.7 62.4 27.5 33.4 10.4 17.0 12.5 13.5 20.9 14.3 9.5 12.8 13.9 19.7 10.6 10.1 14.3 5.8 17.2 29.3 7.2 16.9 13.0 10.5 16.9 14.9 13.2 11.1 12.5 14.7 13.7 14.6 14.0 13.8 24.7 10.9 3.2 19.8 0.0 1.8 0.0 0.0 0.0 0.0 0.0 14.4 9.3 0.0 0.0 5.0 11.0 0.0 13.4 6.9 0.0 5.9 12.2 0.0 9.9 13.5 4.9 0.0 0.0 0.0 17.2 11.0 5.4 0.0 14.8 8.8 11.1 0.0 0.0 21.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.2 0.0 0.0 5.7 0.0 0.0 0.0 0.0 16.2 0.0 0.0 1.9 0.0 0.0 17.2 4.4 0.0 0.0 0.0 5.2 0.0 0.0 0.0 0.0 12.3 3.8 9.6 0.0 0.0 WBP2 "GRAMD6, WBP-2" ENSG00000132471 "WW domain binding protein 2" Q969T9 17 75845699-75856507 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 321.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA065682, HPA068819" Approved Supported Nucleoplasm,Cytosol No No 440000 "Cluster 5: Granulocytes - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 51: Myeloid cells - Hemostasis" "Nucleoplasm, Cytosol" "HPA065682: AB_2685530, HPA068819: AB_2686042" "unprognostic (1.74e-1)" "unprognostic (1.71e-2)" "unprognostic (3.17e-2)" "unprognostic (2.85e-1)" "unprognostic (8.39e-2)" "unprognostic (7.12e-2)" "unprognostic (8.89e-2)" "unprognostic (3.09e-1)" "unprognostic (2.68e-3)" "unprognostic (1.58e-1)" "unprognostic (4.54e-3)" "unprognostic (6.18e-2)" "unprognostic (2.21e-1)" "unprognostic (5.86e-3)" "unprognostic (1.30e-1)" "unprognostic (2.13e-2)" "unprognostic (1.76e-1)" 113.2 223.6 239.5 57.1 238.6 82.7 114.1 225.1 340.9 103.2 163.6 109.7 65.2 84.6 44.3 94.7 106.1 62.8 183.1 243.0 242.2 125.7 184.4 118.1 60.9 293.9 256.8 113.9 134.5 100.7 116.0 55.4 286.4 103.5 39.0 129.7 137.7 73.5 250.2 131.3 85.7 52.0 226.4 112.5 123.2 95.4 259.8 49.2 83.8 91.9 51.8 97.8 94.7 256.6 104.6 119.9 43.4 52.5 88.0 87.2 57.9 32.7 102.1 74.3 91.8 59.7 104.2 52.9 81.9 47.0 232.2 61.0 45.2 100.9 66.3 40.1 90.4 97.7 66.4 97.6 182.2 40.8 161.6 96.4 94.6 89.4 120.8 127.0 143.8 82.1 68.2 156.7 60.2 107.3 85.8 85.8 37.3 70.8 78.8 57.8 85.4 101.5 109.7 62.3 72.6 114.8 58.5 99.9 163.1 76.3 134.9 102.1 84.3 75.8 66.1 73.6 52.3 145.4 109.6 38.8 212.5 38.3 54.9 239.9 85.0 288.7 53.8 102.6 59.1 68.9 59.5 54.6 54.8 55.3 55.8 47.5 308.9 57.4 136.4 42.0 77.4 93.2 239.5 238.6 225.1 340.9 243.0 242.2 293.9 256.8 286.4 226.4 259.8 256.6 73.5 83.3 79.0 34.9 62.7 60.9 127.2 85.9 30.1 109.7 75.2 53.3 73.2 55.8 59.9 53.3 75.0 64.9 45.9 65.9 162.4 124.3 264.5 41.5 21.7 63.4 33.6 124.0 23.6 188.6 65.1 43.5 34.1 44.3 67.0 40.0 54.3 61.9 138.4 112.7 23.4 48.9 71.2 65.5 71.2 321.1 59.4 90.2 60.5 23.4 90.8 104.8 52.5 21.1 38.6 126.5 72.6 53.8 35.6 120.2 88.4 100.7 44.8 120.7 26.3 43.8 44.9 45.5 25.7 24.8 80.0 184.7 51.7 62.5 27.1 95.6 WDR36 "GLC1G, TA-WDRP, UTP21" ENSG00000134987 "WD repeat domain 36" Q8NI36 5 111091716-111130502 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Ribosome biogenesis, rRNA processing, Sensory transduction, Vision" "Disease variant, Glaucoma" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Basal squamous epithelial cells: 113.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037796, HPA037797" Supported Supported Nucleoli NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 3: T-cells - Adaptive immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 59: Non-specific - Transcription" Nucleoli "HPA037796: AB_2675673, HPA037797: AB_10672725" "unprognostic (2.14e-1)" "unprognostic (4.56e-2)" "unprognostic (1.45e-2)" "unprognostic (2.81e-1)" "unprognostic (2.60e-1)" "unprognostic (1.09e-2)" "unprognostic (1.29e-2)" "unprognostic (1.64e-1)" "unprognostic (9.79e-2)" "unprognostic (7.10e-3)" "unprognostic (3.09e-1)" "unprognostic (1.92e-1)" "unprognostic (5.31e-2)" "unprognostic (1.12e-1)" "unprognostic (1.93e-1)" "prognostic unfavorable (1.18e-4)" "unprognostic (4.91e-2)" 9.1 6.3 3.5 9.4 3.5 9.9 10.1 4.7 4.5 7.4 4.1 7.0 6.5 9.0 6.6 7.9 6.8 7.2 6.0 3.9 4.1 7.5 14.1 6.3 11.3 3.6 4.0 10.1 6.4 7.3 4.5 7.5 3.8 8.3 8.1 4.7 6.0 7.0 9.1 10.1 6.8 7.5 3.8 8.8 7.3 6.3 3.9 9.1 9.7 7.2 12.0 9.8 6.1 4.2 17.0 14.9 13.7 36.6 24.7 32.2 19.2 14.6 13.9 19.5 27.9 19.1 19.7 53.8 17.0 12.2 22.7 19.2 26.8 33.8 34.8 15.9 15.7 26.6 17.2 19.5 26.3 25.6 38.8 19.2 21.4 34.6 37.5 36.5 20.3 18.4 32.3 18.1 25.8 14.3 31.7 24.9 18.3 16.8 15.6 25.6 29.9 42.4 18.1 19.3 24.3 19.5 18.6 15.2 22.4 15.0 15.2 21.3 19.1 28.1 15.6 20.0 30.5 18.1 14.0 48.6 22.4 37.9 22.2 0.3 2.5 1.0 3.3 3.3 3.8 2.7 3.0 3.7 4.0 2.4 4.3 3.6 0.1 3.3 5.0 2.1 3.8 2.6 3.5 3.5 4.7 4.5 3.9 4.1 3.6 4.0 3.8 3.8 3.9 4.2 17.2 19.2 13.8 15.3 26.0 61.1 15.4 18.3 113.3 9.9 14.5 12.1 15.6 18.6 19.6 16.5 6.2 9.4 15.4 5.3 7.9 9.5 5.1 10.6 26.0 20.4 6.0 20.6 30.5 13.8 9.9 20.7 13.7 16.2 14.0 16.9 12.5 35.1 14.7 11.8 24.8 12.9 16.2 24.1 16.0 4.2 8.7 18.2 21.4 20.6 18.3 5.7 16.5 27.6 22.3 9.9 6.4 11.3 27.5 20.8 5.3 11.3 12.3 8.6 19.7 20.2 17.3 18.5 17.8 42.3 57.8 5.3 18.0 18.1 13.4 11.2 WDR45 "JM5, NBIA5, WDRX1, WIPI4" ENSG00000196998 "WD repeat domain 45" Q9Y484 X 49074433-49101170 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Autophagy "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027562 Uncertain NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 68: Epididymis - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA027562: AB_10610565" "unprognostic (1.39e-1)" "prognostic favorable (1.21e-4)" "unprognostic (1.82e-2)" "unprognostic (1.33e-1)" "unprognostic (2.32e-1)" "prognostic favorable (1.61e-4)" "unprognostic (4.30e-2)" "unprognostic (6.66e-3)" "unprognostic (7.12e-2)" "unprognostic (3.57e-1)" "unprognostic (3.22e-2)" "unprognostic (1.77e-1)" "unprognostic (5.06e-3)" "unprognostic (2.85e-1)" "unprognostic (5.27e-1)" "unprognostic (3.60e-2)" "unprognostic (1.11e-3)" 58.0 74.7 53.3 22.4 59.1 43.2 54.3 56.1 57.8 54.8 59.4 52.3 27.6 51.5 208.4 38.5 45.7 29.7 79.6 53.6 55.3 61.8 68.5 46.6 25.7 63.8 61.1 49.0 58.6 54.8 43.4 21.9 58.1 48.9 19.6 21.2 50.8 34.4 115.9 48.5 38.2 24.7 57.8 45.0 59.0 10.0 61.0 32.3 52.9 87.5 23.2 45.9 43.0 52.7 36.3 41.9 23.4 23.7 50.1 63.7 45.7 39.0 80.6 30.1 42.1 22.1 51.5 25.1 21.6 77.1 38.6 30.8 35.3 31.6 21.6 27.6 61.0 15.6 79.5 33.5 114.2 12.1 34.5 57.2 54.9 49.4 52.1 47.8 30.7 23.8 33.3 42.8 40.3 40.9 25.6 31.0 23.8 15.9 36.3 20.4 34.8 85.7 53.2 32.8 31.3 46.8 49.2 37.5 120.5 29.9 23.9 43.4 41.8 32.8 29.4 65.6 16.6 66.2 48.9 18.1 60.1 19.5 24.1 125.4 89.0 82.0 54.5 81.6 54.3 49.1 41.0 51.4 67.1 48.4 32.0 36.5 88.9 83.7 97.9 68.0 65.3 72.0 53.3 59.1 56.1 57.8 53.6 55.3 63.8 61.1 58.1 57.8 61.0 52.7 36.5 32.1 34.6 15.0 34.0 46.5 54.2 49.3 36.5 18.8 43.7 41.8 35.8 35.8 42.6 35.0 12.5 30.6 56.5 37.9 56.7 71.3 1.3 22.5 35.0 30.5 28.8 71.8 8.9 98.5 56.8 50.8 43.3 26.1 27.3 27.5 35.0 49.7 42.1 26.9 9.3 32.2 10.2 38.8 44.1 3.8 40.4 47.1 35.6 6.5 74.8 38.7 68.0 4.5 11.0 109.6 44.0 32.4 86.5 67.9 68.5 131.2 23.4 24.0 19.7 42.4 44.5 2.6 5.0 24.8 47.3 62.1 33.4 48.3 28.7 73.4 WDR81 "CAMRQ2, FLJ33817, PPP1R166, SORF-2" ENSG00000167716 "WD repeat domain 81" Q562E7 17 1716523-1738599 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Hepatocytes: 27.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023044, HPA063703" Uncertain Approved Nucleoplasm,Vesicles,Cytosol "Intracellular and membrane" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 18: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 4: Macrophages - Innate immune response" Nucleoplasm "Vesicles, Cytosol" "HPA023044: AB_1858822, HPA063703: " "unprognostic (1.00e-1)" "unprognostic (4.67e-2)" "unprognostic (6.63e-2)" "unprognostic (4.90e-3)" "unprognostic (6.10e-2)" "unprognostic (7.75e-3)" "unprognostic (2.01e-1)" "unprognostic (2.09e-1)" "unprognostic (3.06e-2)" "unprognostic (1.60e-2)" "prognostic favorable (3.30e-4)" "unprognostic (3.26e-1)" "unprognostic (8.72e-2)" "unprognostic (2.25e-1)" "unprognostic (8.43e-2)" "unprognostic (7.99e-2)" "unprognostic (3.90e-2)" 17.7 16.2 4.5 4.6 5.4 4.9 16.9 4.6 6.3 18.2 6.6 11.5 4.8 18.9 2.4 9.9 17.4 1.6 10.9 4.3 4.4 11.9 32.8 13.7 5.6 5.9 5.1 21.4 11.0 2.4 13.1 3.9 5.3 16.0 1.7 0.8 11.0 5.9 18.2 18.4 17.8 5.1 4.7 24.3 11.0 7.5 6.1 6.6 10.5 2.1 4.2 15.4 13.7 6.4 0.7 12.3 1.7 9.1 12.4 7.0 9.2 0.9 0.2 0.6 0.0 1.8 4.4 4.9 6.5 5.4 6.2 12.2 6.3 8.4 0.4 9.5 12.8 0.3 8.8 5.9 22.1 4.1 7.6 17.8 8.8 5.9 4.1 1.9 5.0 3.7 1.0 6.3 7.6 6.8 1.3 7.6 3.9 4.2 9.4 6.4 2.9 6.8 3.7 2.0 2.2 5.0 4.3 3.4 15.4 0.1 6.0 6.1 6.8 4.8 5.4 7.9 6.7 0.5 1.3 3.1 7.7 5.9 2.4 0.0 1.4 2.8 1.1 2.3 1.3 1.3 1.2 1.2 1.8 1.0 0.8 1.1 0.3 2.1 2.3 3.3 1.2 1.1 4.5 5.4 4.6 6.3 4.3 4.4 5.9 5.1 5.3 4.7 6.1 6.4 6.3 12.8 10.3 6.5 4.2 2.5 2.9 4.4 8.6 4.5 4.8 5.3 3.6 4.3 3.8 0.0 4.2 2.5 9.9 6.8 1.9 3.1 0.7 2.1 6.2 5.4 1.2 14.3 5.3 4.5 1.9 8.2 6.6 2.9 4.5 6.2 4.6 27.7 23.8 5.0 5.3 4.6 10.2 22.3 4.5 1.2 16.4 15.3 0.0 9.4 7.5 2.5 9.2 5.0 7.6 4.8 4.8 15.1 5.3 2.9 8.7 20.1 6.4 1.8 19.7 5.9 4.5 0.7 2.0 3.4 1.7 2.3 4.7 5.8 4.4 1.7 WFS1 "DFNA14, DFNA38, DFNA6, DIDMOAD, WFS" ENSG00000109501 "Wolframin ER transmembrane glycoprotein" O76024 4 6269849-6303265 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Cataract, Deafness, Diabetes insipidus, Diabetes mellitus, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 131.4;Extravillous trophoblasts: 120.2;Granulosa cells: 71.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "BEWO: 100.4;Hep G2: 83.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029128 Approved NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 28: BEWO - Transcription regulation" "Cluster 40: Granulosa cells - Unknown function" "HPA029128: AB_10603460" "unprognostic (4.27e-2)" "unprognostic (5.05e-2)" "unprognostic (1.58e-1)" "prognostic favorable (1.13e-6)" "unprognostic (7.35e-2)" "unprognostic (1.29e-2)" "unprognostic (2.73e-2)" "unprognostic (6.97e-3)" "unprognostic (2.37e-1)" "unprognostic (1.78e-1)" "unprognostic (8.36e-3)" "unprognostic (5.33e-3)" "unprognostic (6.20e-2)" "unprognostic (5.02e-2)" "unprognostic (9.10e-2)" "prognostic unfavorable (3.13e-4)" "unprognostic (3.64e-2)" 39.4 20.2 43.7 6.8 71.2 0.7 36.0 34.3 47.2 51.9 34.5 44.8 12.2 75.4 14.0 11.3 58.6 12.4 64.3 35.9 36.8 16.8 17.1 43.8 5.9 34.4 43.7 87.1 20.1 7.2 50.2 16.6 36.6 34.6 3.4 6.9 14.6 36.3 16.0 26.8 22.0 17.0 33.7 29.3 29.1 31.8 44.1 2.9 48.1 7.5 2.3 57.8 29.1 32.1 14.1 35.3 9.1 33.9 37.2 10.2 100.4 23.0 32.7 15.8 14.6 24.8 37.2 5.5 34.3 26.3 74.8 8.0 6.8 14.2 6.4 5.7 14.1 0.0 11.0 83.0 34.5 0.0 1.1 33.7 18.8 15.0 13.6 12.3 25.3 2.5 0.6 24.3 9.7 28.0 1.1 0.3 13.5 20.3 38.0 3.4 9.6 7.5 6.7 52.4 6.1 15.4 12.2 17.4 13.1 9.6 31.5 0.3 19.9 19.8 22.8 19.1 14.8 26.0 10.1 0.5 23.9 0.2 18.3 0.0 0.7 0.0 2.7 0.9 3.9 2.4 1.3 2.1 0.2 1.2 1.3 1.5 0.0 1.5 1.1 0.4 0.8 1.4 43.7 71.2 34.3 47.2 35.9 36.8 34.4 43.7 36.6 33.7 44.1 32.1 38.4 131.4 12.4 40.5 3.6 2.4 1.9 2.5 2.2 4.9 9.7 6.0 42.5 5.7 5.7 25.8 0.0 22.2 1.0 2.0 0.0 5.5 10.3 18.1 12.6 21.1 33.5 0.0 2.7 4.4 120.2 15.4 13.3 25.5 1.3 71.4 21.4 10.7 19.0 3.3 4.7 5.7 4.1 1.3 2.4 19.1 40.0 2.5 12.4 12.2 0.7 31.7 0.0 9.5 2.4 10.9 1.6 57.9 19.0 4.7 3.7 3.7 12.1 5.0 13.1 3.6 15.1 10.8 14.6 2.2 3.4 39.7 1.6 11.0 4.7 2.1 WHRN "CIP98, DFNB31, PDZD7B, USH2D" ENSG00000095397 Whirlin Q9P202 9 114402080-114505473 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" Hearing "Deafness, Non-syndromic deafness, Retinitis pigmentosa, Usher syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 104.7" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 49.5;Endometrial stromal cells: 13.9;Glandular and luminal cells: 39.6;Plasma cells: 14.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "Karpas-707: 97.9;U-266/70: 67.8;U-266/84: 89.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 35: T-regs - Unknown function" "Cluster 43: Testis - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 24: Non-specific - Transcription regulation" "unprognostic (6.06e-3)" "unprognostic (1.02e-1)" "unprognostic (9.96e-2)" "unprognostic (4.27e-3)" "unprognostic (4.59e-1)" "unprognostic (7.07e-2)" "unprognostic (3.66e-2)" "unprognostic (7.25e-2)" "unprognostic (6.13e-3)" "unprognostic (3.43e-2)" "prognostic favorable (2.28e-4)" "unprognostic (1.03e-1)" "unprognostic (1.71e-3)" "unprognostic (3.21e-2)" "unprognostic (1.92e-1)" "unprognostic (1.25e-2)" "unprognostic (3.44e-1)" 5.8 104.7 21.7 2.3 33.5 2.6 5.9 24.0 28.9 17.8 47.2 12.4 3.8 36.4 4.1 5.6 11.5 2.3 8.1 21.7 29.3 7.9 4.8 5.0 2.8 37.2 27.5 20.5 14.1 7.1 36.8 1.8 41.4 13.8 1.2 12.4 8.7 4.0 0.5 9.1 8.9 6.3 24.2 20.7 7.9 50.1 31.5 8.6 10.1 0.2 0.9 6.5 7.2 58.7 2.0 2.0 2.4 11.3 1.1 0.5 5.2 1.0 1.9 1.5 0.9 1.0 0.9 0.0 3.0 1.2 16.2 5.3 0.6 1.3 0.4 31.0 7.1 0.0 23.4 3.1 0.6 0.2 0.6 1.0 4.9 5.3 0.4 6.9 0.1 2.6 9.6 97.9 1.4 14.7 0.2 0.3 4.7 0.1 18.1 1.6 0.0 32.3 3.8 0.6 14.9 1.1 6.8 10.2 29.7 3.2 8.0 0.3 1.6 3.4 2.2 4.3 5.6 67.8 89.6 0.7 2.0 0.1 2.6 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.4 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.3 0.0 21.7 33.5 24.0 28.9 21.7 29.3 37.2 27.5 41.4 24.2 31.5 58.7 1.1 0.0 0.6 0.0 5.2 0.0 0.0 0.0 0.0 0.0 9.2 10.3 0.0 0.0 1.3 0.0 0.0 2.9 10.2 0.0 0.0 1.7 0.0 49.5 13.9 0.7 0.0 0.0 0.0 2.0 2.0 2.0 0.0 39.6 2.5 4.5 0.0 0.0 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 14.3 0.0 0.0 1.3 8.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 4.2 7.8 7.1 0.0 0.0 WNK1 "HSAN2, HSN2, PPP1R167, PRKWNK1" ENSG00000060237 "WNK lysine deficient protein kinase 1" Q9H4A3 12 752579-911452 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Protein kinase inhibitor, Serine/threonine-protein kinase, Transferase" "Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 293.0" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 336.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046541, HPA059157" Enhanced Supported Cytosol NA NA 92000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 70: Brain - Nervous system development" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Cytosol "HPA046541: AB_2679690, HPA059157: AB_2683935" "unprognostic (1.40e-1)" "unprognostic (1.54e-2)" "unprognostic (4.82e-2)" "unprognostic (1.75e-1)" "unprognostic (1.27e-1)" "unprognostic (7.68e-2)" "unprognostic (1.05e-3)" "unprognostic (1.57e-1)" "unprognostic (1.24e-1)" "prognostic unfavorable (9.67e-4)" "unprognostic (1.84e-1)" "unprognostic (2.49e-1)" "unprognostic (4.38e-1)" "unprognostic (1.40e-1)" "unprognostic (1.32e-1)" "unprognostic (5.17e-2)" "unprognostic (1.30e-2)" 56.7 20.6 190.8 36.4 236.8 54.2 33.5 179.4 166.1 32.8 110.8 22.8 14.4 26.7 30.4 72.1 29.4 27.1 63.8 132.3 161.1 84.0 31.6 44.6 39.2 232.3 238.4 30.1 22.5 51.1 17.0 36.0 217.0 29.7 24.2 87.4 24.0 33.4 79.7 52.0 17.4 36.1 225.4 30.2 27.6 48.3 238.0 61.3 27.7 79.8 46.9 35.8 43.8 293.0 53.9 97.5 131.8 11.3 88.1 80.0 52.2 48.3 61.6 58.2 51.3 59.4 55.7 71.0 16.8 107.8 73.5 39.8 93.8 56.7 84.3 124.7 51.4 169.4 122.2 46.1 66.7 86.9 68.2 64.0 82.1 97.6 164.4 61.6 73.4 68.0 76.4 158.2 77.8 54.1 154.6 15.6 105.8 47.8 24.3 78.0 138.8 20.8 80.6 96.8 35.1 40.7 121.8 82.9 33.6 183.3 86.8 97.2 78.3 67.1 77.3 86.2 70.8 23.8 43.1 103.8 59.4 44.6 53.2 0.7 1.8 1.6 1.9 2.1 1.9 1.7 1.9 2.1 1.4 1.2 1.2 1.9 5.6 1.4 4.7 1.2 3.4 1.6 190.8 236.8 179.4 166.1 132.3 161.1 232.3 238.4 217.0 225.4 238.0 293.0 261.1 102.5 141.6 77.1 65.3 112.8 42.3 38.3 85.4 87.9 50.6 39.5 241.6 50.1 47.1 90.1 150.1 32.5 83.0 27.8 86.1 28.0 29.7 63.0 68.6 106.7 58.7 304.2 182.3 24.4 32.9 58.3 37.2 70.2 52.6 46.2 52.5 71.7 57.3 84.1 165.0 26.3 16.2 121.4 80.8 21.2 61.8 96.7 37.4 114.3 95.7 64.0 61.8 126.7 336.4 41.7 34.8 55.7 76.5 59.0 24.2 21.8 64.6 96.1 13.1 69.6 63.8 186.5 74.6 147.2 136.0 28.5 112.9 33.2 25.8 55.2 WWOX "FOR, SDR41C1, WOX1" ENSG00000186153 "WW domain containing oxidoreductase" Q9NZC7 16 78099430-79212667 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Wnt signaling pathway" Oxidoreductase "Disease variant, Epilepsy, Neurodegeneration, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 14 "Astrocytes: 927.8;Excitatory neurons: 270.5;Inhibitory neurons: 540.9;Microglial cells: 471.2;Oligodendrocyte precursor cells: 914.9;Oligodendrocytes: 793.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "MCF7: 85.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA050992 Approved Supported "Golgi apparatus,Cytosol" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 68: Epididymis - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Golgi apparatus" Cytosol "HPA050992: AB_2681299" "prognostic unfavorable (9.07e-5)" "unprognostic (1.14e-2)" "unprognostic (1.92e-1)" "unprognostic (9.27e-2)" "unprognostic (2.32e-1)" "unprognostic (1.81e-1)" "unprognostic (6.24e-2)" "unprognostic (1.69e-1)" "unprognostic (1.65e-1)" "unprognostic (3.61e-3)" "unprognostic (4.33e-2)" "unprognostic (3.50e-2)" "prognostic favorable (4.49e-5)" "unprognostic (3.75e-1)" "unprognostic (1.78e-1)" "unprognostic (2.36e-2)" "unprognostic (1.77e-1)" 8.6 6.3 18.6 4.0 23.9 4.2 7.4 24.0 20.3 8.6 21.2 5.2 5.3 8.2 10.1 7.7 9.0 7.4 5.2 18.8 22.5 12.7 12.0 5.3 4.6 24.0 22.4 7.6 8.3 12.1 9.8 5.3 25.3 7.7 3.2 6.9 8.5 6.4 3.3 7.1 4.5 5.1 22.0 4.7 6.0 9.3 21.0 9.0 21.8 2.1 6.0 6.7 7.1 30.0 11.1 9.5 9.2 7.7 11.0 5.3 11.1 1.6 3.2 3.7 3.2 7.0 9.6 19.5 8.6 1.5 5.2 10.0 5.1 1.3 2.6 11.0 26.8 6.0 1.9 15.7 7.5 16.7 3.4 5.9 3.8 2.3 2.4 0.9 4.4 25.9 9.2 4.2 2.6 85.7 27.7 21.9 8.6 5.9 5.7 32.2 3.9 19.1 5.3 3.9 17.6 10.0 7.1 11.9 4.0 9.3 12.8 12.0 1.6 2.7 10.4 2.2 6.4 0.0 18.3 41.2 10.4 8.4 4.6 7.0 9.1 2.1 11.4 7.9 13.4 9.3 8.2 9.1 7.7 6.6 8.4 8.3 0.7 9.1 5.8 14.5 13.5 6.0 18.6 23.9 24.0 20.3 18.8 22.5 24.0 22.4 25.3 22.0 21.0 30.0 12.0 6.4 6.9 927.8 9.0 9.2 21.2 8.0 19.4 7.4 12.1 16.1 8.8 17.2 13.3 14.7 4.2 25.7 10.9 4.5 33.2 12.4 43.1 18.2 13.9 9.5 9.6 13.3 270.5 10.3 11.9 12.0 9.2 7.6 12.7 18.7 13.2 18.9 9.2 5.0 540.9 5.1 0.0 5.6 5.7 38.2 14.0 7.7 5.4 471.2 5.9 46.3 9.2 914.9 793.5 4.5 5.9 17.7 18.4 11.5 8.7 28.3 18.7 12.2 6.6 10.3 11.8 19.7 17.9 13.3 6.8 17.4 9.9 12.1 6.8 13.0 XK "Kx, NA, NAC, X1k, XKR1" ENSG00000047597 "X-linked Kx blood group" P51811 X 37685791-37732130 "Blood group antigen proteins, Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Amino-acid transport, Transport" "Blood group antigen" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 14.2;intestine: 12.2;stomach 1: 11.5" "Cell type enhanced" "Detected in many" "Distal enterocytes: 26.7;Erythroid cells: 63.5;Gastric mucus-secreting cells: 17.9;Proximal enterocytes: 21.5;Undifferentiated cells: 14.7" "Cancer enhanced" "Detected in many" "colorectal cancer: 6.5" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 53 "basophil: 10.2;eosinophil: 5.8" "Lineage enriched" "Detected in single" 102 "granulocytes: 10.2" "Cell line enhanced" "Detected in many" "HEL: 44.4;HL-60: 23.2;K-562: 29.1;NB-4: 21.1;RPMI-8226: 20.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019036 Approved Approved Nucleoplasm,Vesicles,Mitochondria No No "Cluster 2: Granulocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 1: K-562 - Erythropoiesis" "Cluster 6: Erythroid cells - Oxygen transport" Mitochondria "Nucleoplasm, Vesicles" "HPA019036: AB_1846286" "unprognostic (2.37e-2)" "unprognostic (7.13e-3)" "unprognostic (5.03e-2)" "unprognostic (1.00e-2)" "unprognostic (7.97e-2)" "unprognostic (4.56e-1)" "unprognostic (3.59e-2)" "unprognostic (4.00e-2)" "unprognostic (4.77e-3)" "unprognostic (5.07e-2)" "unprognostic (6.63e-2)" "unprognostic (5.90e-2)" "unprognostic (4.44e-8)" "unprognostic (1.74e-1)" "unprognostic (4.75e-2)" "unprognostic (1.06e-1)" "unprognostic (1.43e-1)" 0.2 2.1 2.5 1.4 2.5 14.2 0.7 2.3 3.0 1.2 0.2 12.2 10.8 0.7 0.5 2.0 3.8 0.9 4.3 3.2 4.9 0.9 0.8 1.0 0.2 1.6 0.9 0.7 4.9 0.7 1.3 0.7 2.0 1.5 11.2 2.1 1.2 0.9 5.4 0.7 10.6 1.8 0.5 0.5 11.5 1.4 2.8 0.2 0.9 5.8 0.5 1.1 0.8 1.4 17.4 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.9 14.7 0.3 0.0 0.8 2.7 15.4 0.1 0.0 0.0 4.2 44.4 2.4 0.0 0.0 23.2 3.5 0.0 0.8 0.0 0.0 0.0 0.0 0.0 29.1 10.9 0.1 1.7 0.2 21.1 5.5 0.7 5.6 0.0 0.0 20.2 0.0 1.1 4.1 0.1 0.8 1.4 0.1 0.9 2.1 5.6 0.0 0.0 0.8 0.0 2.4 9.3 16.5 0.0 0.2 12.1 0.1 10.2 0.0 5.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 2.5 2.5 2.3 3.0 3.2 4.9 1.6 0.9 2.0 0.5 2.8 1.4 0.0 0.0 1.1 2.6 0.8 0.4 0.4 0.1 1.2 0.7 1.1 0.8 7.9 0.0 0.1 0.0 6.2 0.3 0.1 26.7 0.0 0.0 1.2 4.0 0.1 0.3 6.1 63.5 11.0 3.1 0.1 0.6 17.9 0.9 0.0 0.1 0.0 0.9 0.1 3.3 12.6 10.9 2.0 0.3 0.0 0.4 0.0 0.2 1.8 1.9 0.0 0.0 0.0 4.5 1.2 1.1 9.2 0.7 2.2 0.9 21.5 0.1 1.7 1.4 0.0 0.7 1.3 10.2 6.1 3.8 1.1 0.0 0.3 0.1 14.7 1.5 XPR1 "SLC53A1, SYG1, X3" ENSG00000143324 "Xenotropic and polytropic retrovirus receptor 1" Q9UBH6 1 180632022-180890279 "Disease related genes, Human disease related genes, Predicted membrane proteins" "Host cell receptor for virus entry, Receptor" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 100.9;Excitatory neurons: 118.2;Inhibitory neurons: 102.5;Microglial cells: 102.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SH-SY5Y: 145.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016557 Supported NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 46: Fibroblasts - ECM organization" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA016557: AB_2669382" "unprognostic (2.65e-1)" "unprognostic (2.68e-2)" "unprognostic (1.92e-2)" "unprognostic (1.42e-2)" "unprognostic (2.86e-1)" "unprognostic (1.30e-3)" "prognostic unfavorable (3.04e-4)" "unprognostic (2.76e-1)" "unprognostic (2.59e-1)" "unprognostic (3.78e-2)" "unprognostic (4.72e-2)" "unprognostic (6.44e-2)" "unprognostic (8.82e-2)" "unprognostic (7.04e-2)" "unprognostic (1.38e-1)" "unprognostic (2.59e-1)" "unprognostic (8.44e-2)" 7.7 9.0 6.4 7.3 7.8 6.2 6.6 4.5 8.0 19.3 13.8 9.2 11.0 10.9 7.4 7.2 15.3 8.5 30.3 5.3 10.5 20.3 6.3 10.1 5.9 5.6 8.7 7.3 12.6 20.3 6.1 14.1 7.6 6.5 9.9 10.1 6.1 10.1 5.4 4.2 11.0 9.8 5.5 7.0 4.6 16.7 11.5 8.5 13.6 8.3 6.7 12.4 4.4 4.7 16.1 22.6 54.4 19.1 17.9 24.1 51.5 18.2 24.1 12.1 12.9 32.6 23.2 15.2 42.3 21.1 19.2 42.7 22.0 32.3 17.8 21.4 14.1 19.7 15.0 23.3 20.9 16.6 20.7 20.2 31.3 17.2 35.5 19.7 26.7 20.2 61.3 24.7 28.8 14.7 15.9 7.6 51.4 20.3 4.9 16.6 19.5 20.2 30.8 32.8 34.6 145.7 25.0 22.0 16.0 37.0 19.5 18.8 22.3 15.9 15.3 22.9 23.1 27.3 27.5 29.9 11.5 16.3 26.4 0.9 4.5 2.1 3.1 8.4 2.7 1.6 2.8 2.8 3.8 2.0 2.6 2.7 4.3 2.8 13.4 1.1 3.2 3.2 6.4 7.8 4.5 8.0 5.3 10.5 5.6 8.7 7.6 5.5 11.5 4.7 22.4 9.6 14.4 100.9 11.2 25.6 19.7 22.6 55.8 16.3 11.0 9.1 47.3 15.7 15.0 5.5 27.1 13.7 5.3 20.2 3.9 22.3 19.4 27.1 13.3 21.3 12.0 18.3 118.2 44.6 6.6 10.7 8.2 48.2 7.6 11.6 15.0 11.9 9.8 13.5 102.5 7.0 20.3 21.4 17.7 9.7 4.7 14.8 10.6 102.1 9.7 8.1 12.3 79.9 47.5 23.5 12.4 14.3 13.4 13.5 25.6 24.3 23.0 10.5 6.6 8.9 10.5 15.5 17.5 22.3 17.0 7.7 13.4 10.0 10.4 14.1 XRCC1 RCC ENSG00000073050 "X-ray repair cross complementing 1" P18887 19 43543311-43580473 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" "DNA damage, DNA repair" "Cancer-related genes, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005427, HPA006717" Supported Enhanced Nucleoplasm NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 49: Ciliated cells - Cilium organization" Nucleoplasm "CAB005427: AB_2215661, HPA006717: AB_1858896" "unprognostic (1.10e-2)" "unprognostic (3.51e-3)" "unprognostic (4.59e-1)" "unprognostic (2.81e-2)" "unprognostic (4.08e-1)" "unprognostic (2.68e-2)" "prognostic unfavorable (7.33e-5)" "unprognostic (5.07e-2)" "unprognostic (3.12e-1)" "unprognostic (7.51e-2)" "unprognostic (3.00e-2)" "unprognostic (9.54e-2)" "unprognostic (1.07e-1)" "unprognostic (2.28e-1)" "unprognostic (9.34e-3)" "unprognostic (2.20e-2)" "unprognostic (5.69e-2)" 18.5 16.4 15.3 18.0 15.6 24.4 17.9 18.5 17.1 23.6 13.5 20.4 14.6 23.5 16.2 16.1 23.2 14.4 15.5 14.6 15.6 15.7 10.8 16.2 22.9 15.7 15.2 32.0 19.6 17.6 32.3 16.6 14.0 16.2 11.4 16.7 16.3 15.6 19.5 21.0 15.7 17.3 13.5 20.1 18.5 23.9 16.6 29.0 20.6 15.7 20.9 18.6 18.0 15.6 57.4 51.4 54.4 48.2 23.6 24.6 27.0 28.4 36.0 42.5 46.3 32.0 40.4 44.1 39.1 28.9 39.1 30.0 33.2 36.8 24.7 46.4 33.9 57.5 49.4 36.1 23.2 34.5 42.9 27.3 24.8 53.5 26.4 48.8 37.2 49.1 35.9 42.5 37.3 48.9 57.5 52.5 18.5 44.2 21.3 57.0 35.4 25.8 34.3 44.1 44.5 26.5 41.6 35.3 20.7 26.8 33.9 67.4 23.3 55.7 40.4 16.3 39.9 44.2 44.2 32.0 42.8 28.0 58.7 18.6 13.1 15.6 10.8 11.9 12.3 11.7 13.8 14.6 11.6 10.5 11.3 10.9 15.1 10.4 7.9 9.1 14.5 11.7 15.3 15.6 18.5 17.1 14.6 15.6 15.7 15.2 14.0 13.5 16.6 15.6 10.2 16.0 9.8 5.9 13.4 6.1 7.1 17.5 12.5 12.6 10.2 9.0 7.6 7.2 14.7 7.3 6.2 29.8 12.5 9.1 19.6 15.4 32.2 18.7 13.3 12.2 13.7 15.4 8.2 11.6 19.2 13.3 8.2 13.7 19.7 22.0 11.4 7.1 21.0 5.0 9.2 15.3 10.2 18.0 10.1 19.5 10.2 12.6 14.2 3.7 14.3 8.6 8.2 4.5 8.1 12.2 9.7 12.8 17.7 4.1 9.2 16.9 39.0 12.7 6.6 9.6 17.7 21.4 14.1 10.8 7.1 20.0 14.6 16.4 13.7 4.7 YARS1 "tyrRS, YARS, YRS, YTS" ENSG00000134684 "Tyrosyl-tRNA synthetase 1" P54577 1 32775237-32817380 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Protein biosynthesis" "Aminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding" "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 17.5;Cytotrophoblasts: 41.8;Extravillous trophoblasts: 48.1;Hofbauer cells: 41.0;Syncytiotrophoblasts: 37.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017936, HPA018950, HPA018954" Enhanced Enhanced Cytosol No No 1400000 "Cluster 48: NK-cells - Unknown function" "Cluster 22: Non-specific - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 24: Non-specific - Transcription regulation" Cytosol "HPA017936: AB_1858916, HPA018950: AB_1858919, HPA018954: AB_1858915" "unprognostic (4.05e-2)" "unprognostic (2.52e-1)" "unprognostic (4.21e-1)" "unprognostic (4.78e-2)" "unprognostic (9.54e-2)" "unprognostic (3.38e-3)" "prognostic unfavorable (6.97e-11)" "unprognostic (5.05e-2)" "unprognostic (6.29e-2)" "unprognostic (1.93e-1)" "unprognostic (1.81e-3)" "unprognostic (4.96e-2)" "prognostic unfavorable (1.02e-11)" "unprognostic (3.57e-3)" "unprognostic (1.02e-1)" "unprognostic (4.94e-2)" "prognostic unfavorable (6.57e-4)" 24.9 40.3 39.9 35.0 51.2 19.9 21.3 38.1 60.4 20.5 30.1 27.5 26.0 16.9 25.0 34.4 21.6 15.3 22.4 42.1 46.6 20.6 47.7 27.8 38.2 37.5 38.4 15.1 85.6 34.1 14.8 26.2 42.3 18.8 32.4 38.0 29.6 29.0 31.9 26.0 21.6 35.4 38.5 22.0 40.8 31.2 44.2 34.6 42.3 36.6 50.0 34.6 14.0 49.6 157.1 92.1 86.1 194.5 111.2 117.7 91.7 151.0 136.7 133.2 165.0 116.6 103.0 287.5 63.1 173.2 112.7 90.8 269.0 204.4 198.9 122.6 113.9 254.2 117.2 114.2 383.4 202.9 147.3 129.0 252.3 212.7 544.2 98.3 140.9 245.8 291.8 268.7 117.8 107.8 233.0 159.3 149.1 185.3 134.5 198.3 75.2 234.9 109.8 76.5 149.5 94.2 89.0 102.7 300.8 99.2 95.2 247.5 103.6 73.6 135.7 152.1 135.7 242.8 265.2 255.7 184.8 297.7 203.6 56.1 33.3 17.8 59.0 35.2 58.4 23.8 35.4 55.1 45.8 20.3 25.2 39.0 6.9 98.1 35.0 26.9 40.9 51.5 39.9 51.2 38.1 60.4 42.1 46.6 37.5 38.4 42.3 38.5 44.2 49.6 7.6 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.5 0.0 0.0 0.0 0.0 41.8 11.6 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 48.1 6.3 0.0 0.0 0.0 0.0 0.0 0.0 41.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.1 0.0 0.0 0.0 0.0 37.6 1.4 0.0 0.0 0.0 YEATS2 "FLJ10201, FLJ12841, FLJ13308, KIAA1197" ENSG00000163872 "YEATS domain containing 2" Q9ULM3 3 183697797-183812624 "Disease related genes, Human disease related genes, Predicted intracellular proteins" Epilepsy "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 95.6;Inhibitory neurons: 62.1;Oligodendrocyte precursor cells: 71.9;Oligodendrocytes: 80.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045891 Uncertain Approved Nucleoplasm NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "HPA045891: AB_10961271" "unprognostic (1.57e-2)" "unprognostic (1.10e-1)" "unprognostic (3.56e-2)" "unprognostic (3.40e-3)" "unprognostic (1.14e-1)" "unprognostic (7.49e-2)" "prognostic unfavorable (4.82e-6)" "unprognostic (2.44e-1)" "unprognostic (3.91e-2)" "unprognostic (1.32e-1)" "unprognostic (8.33e-3)" "unprognostic (1.65e-3)" "prognostic unfavorable (6.90e-9)" "unprognostic (1.66e-1)" "unprognostic (1.53e-1)" "unprognostic (1.21e-1)" "unprognostic (2.08e-2)" 7.4 4.8 5.4 8.9 7.4 14.5 7.9 8.1 8.8 8.5 0.0 9.1 5.4 9.0 4.7 8.2 10.3 6.5 6.6 6.4 5.2 6.1 3.4 10.0 12.9 2.4 3.7 15.1 5.4 9.9 8.6 11.2 3.0 8.2 6.8 15.6 8.0 7.3 5.5 8.5 7.0 11.9 1.9 8.9 5.8 8.0 4.2 16.9 9.7 4.8 11.8 8.7 8.4 7.0 38.1 11.3 32.4 14.5 15.5 22.8 35.8 22.1 17.0 32.1 37.5 27.8 13.3 34.7 39.8 19.5 49.9 23.9 31.8 21.2 32.7 28.5 18.8 35.0 12.2 13.7 23.9 26.3 19.4 15.6 16.3 23.1 27.8 32.1 33.1 35.2 14.0 28.3 24.5 10.2 38.3 20.2 29.3 13.8 22.0 53.5 30.5 42.0 12.9 16.6 31.3 22.3 16.4 55.4 29.2 27.1 27.5 17.8 28.2 29.5 21.3 15.1 25.0 26.9 22.6 57.6 22.9 25.8 21.3 0.1 4.6 1.2 1.9 2.0 1.3 1.9 1.7 1.4 1.6 1.3 1.3 1.5 8.5 1.3 7.1 2.1 0.7 1.8 5.4 7.4 8.1 8.8 6.4 5.2 2.4 3.7 3.0 1.9 4.2 7.0 13.8 35.3 2.3 41.4 7.0 2.0 3.3 7.0 8.6 19.5 5.6 7.5 10.1 5.7 5.9 5.5 10.4 4.8 7.4 4.4 0.0 5.7 2.4 10.5 18.3 15.3 8.5 6.3 95.6 4.0 9.7 9.2 7.1 9.8 7.0 42.1 7.5 3.0 7.1 13.5 62.1 6.0 6.1 8.7 6.7 3.3 9.9 10.1 1.8 40.3 6.6 5.8 5.2 71.9 80.0 7.1 3.1 9.4 9.5 5.3 4.7 1.0 11.2 15.8 0.0 10.1 10.4 3.1 12.3 8.7 3.4 2.1 8.8 9.7 4.8 2.8 YME1L1 YME1L ENSG00000136758 "YME1 like 1 ATPase" Q96TA2 10 27110111-27155266 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA066953 Approved Supported "Nuclear bodies,Mitochondria" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" Mitochondria "Nuclear bodies" "HPA066953: AB_2685753" "unprognostic (2.28e-3)" "unprognostic (3.00e-2)" "unprognostic (1.34e-1)" "unprognostic (7.19e-2)" "unprognostic (8.12e-2)" "unprognostic (2.47e-1)" "prognostic unfavorable (8.25e-6)" "unprognostic (7.08e-2)" "unprognostic (2.91e-1)" "unprognostic (9.24e-2)" "unprognostic (9.43e-3)" "unprognostic (1.64e-1)" "unprognostic (1.21e-1)" "unprognostic (1.03e-1)" "unprognostic (5.53e-2)" "unprognostic (1.44e-2)" "unprognostic (7.09e-2)" 48.8 52.6 17.7 51.7 18.4 95.1 47.5 23.3 21.7 52.4 36.4 52.2 46.0 50.3 53.3 59.1 43.7 46.0 61.4 17.8 22.7 54.0 65.5 39.8 56.6 18.2 22.1 50.8 52.0 54.5 33.3 61.1 19.9 48.4 52.4 42.0 44.7 44.5 111.4 40.1 46.3 49.2 16.6 46.4 48.8 51.2 19.7 65.9 62.2 97.7 62.5 56.8 35.0 24.4 146.6 105.3 125.5 62.0 118.3 123.9 100.7 143.3 79.7 139.7 157.6 143.3 171.9 152.1 90.8 154.8 100.5 135.6 152.8 122.6 152.9 143.4 89.0 144.4 91.0 98.3 124.6 100.4 114.5 104.7 143.3 123.4 121.6 122.5 146.7 138.8 173.8 150.5 154.4 95.1 189.1 53.7 97.4 119.3 49.4 160.4 199.7 143.0 107.7 68.2 95.6 121.9 138.4 105.2 138.9 102.8 101.5 115.1 146.9 83.4 117.3 140.8 126.7 75.1 121.9 196.1 119.4 178.8 65.8 195.0 146.4 165.4 147.5 128.5 149.4 143.0 142.4 138.8 121.9 149.7 129.3 136.8 204.0 135.6 143.1 222.6 156.7 155.5 17.7 18.4 23.3 21.7 17.8 22.7 18.2 22.1 19.9 16.6 19.7 24.4 105.4 67.3 81.8 40.5 108.3 70.1 96.7 55.6 92.2 53.1 76.8 90.9 103.6 32.9 66.4 29.5 83.4 61.2 121.0 179.4 15.6 52.2 62.3 141.4 152.5 86.1 50.3 63.1 67.0 48.6 74.4 101.1 136.6 224.3 110.8 75.0 58.5 70.0 73.2 50.5 68.1 121.2 32.6 98.9 133.2 27.0 57.8 125.4 56.9 41.2 63.7 63.8 47.4 66.9 75.2 66.8 109.3 43.2 93.8 83.7 156.5 47.3 70.1 65.7 72.3 156.6 94.5 143.4 57.4 92.5 64.9 94.8 122.1 102.2 104.4 75.0 YWHAG "14-3-3γ, 14-3-3GAMMA, PPP1R170" ENSG00000170027 "Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma" P61981 7 76326799-76358991 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 337.4;skeletal muscle: 349.8" "Cell type enhanced" "Detected in all" "Basal keratinocytes: 408.8;Suprabasal keratinocytes: 425.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013274, CAB018389, HPA026918" Approved Approved Approved Cytosol NA NA 66000000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 28: Keratinocytes - Keratinization" Cytosol "CAB013274: , CAB018389: AB_2217962, HPA026918: AB_10610566" "unprognostic (3.71e-2)" "prognostic unfavorable (4.53e-4)" "unprognostic (3.88e-2)" "unprognostic (1.25e-2)" "unprognostic (6.28e-3)" "unprognostic (2.40e-3)" "unprognostic (8.98e-3)" "prognostic unfavorable (5.34e-4)" "unprognostic (1.63e-1)" "unprognostic (1.64e-1)" "prognostic unfavorable (7.44e-4)" "unprognostic (3.03e-2)" "prognostic unfavorable (4.01e-4)" "unprognostic (9.31e-2)" "unprognostic (1.51e-1)" "unprognostic (2.45e-2)" "unprognostic (1.70e-1)" 188.1 99.2 165.6 60.6 185.3 27.3 61.0 80.2 337.4 41.1 8.5 48.4 47.8 50.9 20.8 64.5 37.9 54.5 111.4 206.5 206.1 50.8 72.4 47.1 43.2 204.5 120.7 40.7 59.7 50.1 32.6 55.4 192.9 46.1 44.0 87.2 39.9 40.0 349.8 43.7 41.6 66.4 81.5 44.2 38.2 28.9 135.1 40.2 29.7 238.4 48.6 78.8 46.3 199.1 189.0 231.9 200.5 256.7 200.5 114.9 90.5 213.3 105.0 129.6 139.5 147.0 196.7 263.5 71.7 190.8 215.2 171.6 254.3 235.8 180.5 179.9 110.9 250.2 150.0 164.5 182.6 309.0 234.0 127.1 221.0 151.5 310.8 137.3 208.9 140.2 349.9 289.0 195.8 177.6 222.3 227.1 223.0 150.7 160.4 256.3 203.0 291.7 204.5 126.3 107.0 297.1 236.7 299.2 156.0 256.9 208.5 184.2 222.6 250.7 145.7 225.4 290.1 95.1 191.6 399.5 225.5 285.3 273.8 1.5 2.3 0.5 0.8 2.0 1.4 1.3 1.0 1.1 2.4 0.7 0.7 0.9 0.5 0.5 1.8 2.6 0.9 0.9 165.6 185.3 80.2 337.4 206.5 206.1 204.5 120.7 192.9 81.5 135.1 199.1 73.7 32.1 26.4 23.2 51.8 408.8 128.3 87.9 126.9 102.9 107.0 70.1 234.0 40.0 55.1 38.6 12.5 36.5 39.3 49.9 37.2 52.4 91.2 96.0 82.9 92.0 85.4 72.8 99.9 38.2 84.1 97.4 61.2 127.9 67.3 38.7 50.0 93.1 83.5 124.5 78.5 35.7 44.7 90.3 229.0 25.2 46.3 87.8 94.3 40.3 64.2 27.1 20.6 23.1 57.1 71.1 29.9 43.2 56.6 129.8 34.1 61.3 47.2 35.3 32.9 92.5 91.5 13.4 19.0 160.1 425.4 67.2 41.5 46.4 45.1 177.1 ZEB1 "AREB6, BZP, FECD6, NIL-2-A, PPCD3, TCF8, ZEB, Zfhep, Zfhx1a" ENSG00000148516 "Zinc finger E-box binding homeobox 1" P37275 10 31318495-31529814 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Differentiation, Neurogenesis, Transcription, Transcription regulation" "Activator, DNA-binding, Repressor" "Corneal dystrophy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 287.8;Excitatory neurons: 276.1;Inhibitory neurons: 261.9;Microglial cells: 479.7;Oligodendrocyte precursor cells: 968.6" "Cancer enhanced" "Detected in all" "glioma: 15.4" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "ASC TERT1: 113.1;TIME: 87.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027524, CAB058686, CAB079943" Enhanced Supported Nucleoplasm,Nucleoli NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 68: Oligodendrocytes - Mixed function" Nucleoplasm Nucleoli "CAB058686: AB_2665569, CAB079943: , HPA027524: AB_1844977" "unprognostic (1.54e-1)" "unprognostic (3.08e-1)" "unprognostic (3.42e-2)" "unprognostic (1.04e-1)" "unprognostic (4.85e-2)" "unprognostic (7.40e-2)" "unprognostic (1.34e-2)" "unprognostic (5.59e-2)" "unprognostic (1.30e-1)" "unprognostic (2.96e-2)" "unprognostic (3.48e-1)" "unprognostic (2.15e-1)" "prognostic unfavorable (7.34e-6)" "unprognostic (5.59e-3)" "unprognostic (1.19e-1)" "unprognostic (1.62e-2)" "unprognostic (1.66e-2)" 26.6 8.6 16.4 12.9 16.2 8.6 16.8 14.0 20.1 33.2 9.9 49.2 6.0 38.7 13.4 11.7 18.6 20.0 34.8 15.2 22.8 7.5 10.4 16.0 9.6 21.1 19.2 9.3 3.8 3.4 7.9 17.5 21.2 14.5 12.3 14.8 8.0 26.9 54.4 7.0 11.8 39.9 16.8 8.1 18.1 10.1 18.2 29.9 11.2 60.5 9.7 24.4 16.4 18.5 0.1 11.1 35.1 43.9 58.4 113.1 0.0 32.7 44.9 6.6 9.3 0.2 0.1 11.3 15.6 39.6 9.3 0.0 14.9 0.0 11.8 19.1 7.9 0.0 7.0 6.3 44.4 9.8 0.3 53.4 0.1 19.6 17.6 21.4 54.9 9.5 7.5 14.4 42.7 0.1 33.7 6.2 2.3 0.0 6.6 11.6 66.0 5.1 12.9 0.0 0.9 15.6 11.1 0.0 0.0 7.2 0.0 6.7 87.7 40.8 9.4 10.0 16.7 9.1 6.3 12.8 10.9 0.0 4.2 4.9 0.0 5.4 2.4 0.0 3.2 4.1 3.2 1.7 1.3 3.1 6.8 3.5 8.5 6.6 0.0 3.1 5.0 1.6 16.4 16.2 14.0 20.1 15.2 22.8 21.1 19.2 21.2 16.8 18.2 18.5 104.4 0.0 7.7 212.9 34.6 11.2 3.0 2.0 0.6 42.7 1.4 2.8 106.3 1.5 3.6 1.8 45.9 0.3 22.0 0.0 0.0 2.1 110.1 7.2 287.8 110.6 0.0 12.2 276.1 2.7 0.5 66.1 2.0 6.5 1.3 17.0 49.6 13.4 1.2 10.1 261.9 0.0 0.0 3.8 25.6 141.8 30.7 6.3 26.6 479.7 10.7 7.2 7.2 968.6 7.3 2.5 0.0 102.0 33.2 3.7 0.0 1.6 1.5 43.4 78.9 99.2 74.2 17.4 15.7 1.1 8.7 0.7 36.2 12.0 0.0 3.8 ZFHX2 "KIAA1056, KIAA1762, ZFH-5, ZNF409" ENSG00000136367 "Zinc finger homeobox 2" Q9C0A1 14 23520857-23556192 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" DNA-binding "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 11.9;testis: 7.3" "Cell type enhanced" "Detected in many" "Astrocytes: 22.5;Early spermatids: 38.9;Excitatory neurons: 31.0;Inhibitory neurons: 20.0;Late spermatids: 19.1;Oligodendrocyte precursor cells: 27.2;Oligodendrocytes: 20.8;Spermatocytes: 16.5" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in many" "cerebellum: 11.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AN3-CA: 4.8;SuSa: 3.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000720, HPA005146" Uncertain Approved "Nucleoplasm,Nucleoli fibrillar center" Yes No "Cluster 9: Neutrophils - Innate immune response" "Cluster 21: Non-specific - Transcription" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 49: Ciliated cells - Cilium organization" "Nucleoli fibrillar center" Nucleoplasm "HPA000720: AB_10603462, HPA005146: AB_1859250" "unprognostic (7.54e-3)" "unprognostic (2.01e-1)" "unprognostic (1.53e-1)" "unprognostic (2.53e-1)" "unprognostic (2.61e-1)" "unprognostic (6.12e-3)" "unprognostic (1.40e-1)" "unprognostic (5.40e-2)" "unprognostic (3.94e-2)" "unprognostic (3.71e-2)" "unprognostic (5.08e-4)" "unprognostic (2.39e-1)" "unprognostic (5.33e-3)" "unprognostic (3.75e-1)" "unprognostic (7.35e-2)" "unprognostic (1.76e-1)" "unprognostic (1.90e-2)" 0.5 0.7 1.8 0.5 6.3 0.1 0.4 11.9 5.3 0.4 0.0 0.7 0.1 0.7 0.4 0.2 2.2 0.4 0.3 3.2 0.0 1.3 0.2 0.5 0.3 1.5 0.1 0.5 0.4 1.7 3.4 0.2 0.2 0.6 0.2 3.1 0.4 1.2 0.7 0.5 0.3 0.6 0.0 0.2 0.4 7.3 0.9 0.2 0.7 0.5 0.2 0.3 0.2 2.3 0.1 3.1 2.4 4.8 1.6 0.2 0.1 0.7 0.2 0.3 1.2 0.3 0.2 0.2 0.3 0.0 0.3 0.1 1.2 0.1 0.5 2.2 0.8 2.5 0.0 0.6 0.2 0.4 1.7 0.3 0.1 0.5 0.1 1.3 0.3 2.1 0.4 0.4 0.1 0.8 0.3 0.3 2.9 0.3 0.7 1.4 0.0 0.0 1.3 1.2 2.7 1.7 0.4 0.6 0.1 3.6 1.0 0.6 0.1 0.0 1.2 0.7 0.3 0.3 1.0 0.1 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.8 6.3 11.9 5.3 3.2 0.0 1.5 0.1 0.2 0.0 0.9 2.3 0.5 0.0 1.1 22.5 0.7 0.1 0.6 1.1 0.0 9.0 2.2 2.3 2.5 0.0 2.4 1.8 0.0 0.3 0.1 0.6 1.9 2.8 38.9 12.2 0.6 1.1 6.7 0.0 31.0 2.4 0.0 1.4 2.0 2.5 0.0 3.2 0.7 0.2 1.0 8.4 20.0 0.7 2.0 1.0 1.9 19.1 0.6 0.8 0.0 4.7 1.0 2.7 0.0 27.2 20.8 1.2 1.2 0.4 0.1 1.4 0.4 1.4 9.8 3.8 0.0 2.5 1.3 16.5 1.2 0.7 0.0 0.3 0.4 0.2 0.6 0.3 ZFYVE26 "KIAA0321, SPG15" ENSG00000072121 "Zinc finger FYVE-type containing 26" Q68DK2 14 67727374-67816590 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Cell cycle, Cell division, DNA damage, DNA repair" "Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 50.1;Rod photoreceptor cells: 126.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 11 "plasmacytoid DC: 4.8" "Lineage enriched" "Detected in single" 11 "dendritic cells: 4.8" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA055500 Approved NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA055500: AB_2682837" "unprognostic (3.14e-2)" "unprognostic (1.12e-1)" "unprognostic (2.08e-1)" "unprognostic (1.16e-1)" "unprognostic (1.96e-1)" "unprognostic (1.02e-2)" "prognostic unfavorable (2.84e-6)" "unprognostic (6.87e-2)" "unprognostic (8.18e-2)" "unprognostic (2.97e-2)" "unprognostic (8.29e-3)" "unprognostic (3.71e-2)" "prognostic favorable (1.54e-6)" "unprognostic (1.61e-1)" "unprognostic (1.58e-1)" "unprognostic (6.69e-2)" "unprognostic (5.34e-2)" 5.3 6.4 4.8 5.4 6.3 5.9 5.3 5.8 5.5 5.6 6.8 5.7 4.1 5.7 4.0 5.5 4.5 4.4 5.1 4.5 5.1 4.9 4.4 6.6 7.0 6.4 6.1 6.6 4.9 7.3 5.5 5.9 5.9 4.8 4.7 6.3 4.8 4.6 8.7 7.1 5.8 6.0 5.0 7.3 5.2 2.7 7.8 6.9 5.2 9.6 6.6 5.2 4.8 6.5 12.1 6.9 7.3 7.8 15.2 6.8 10.7 5.8 9.1 13.0 14.9 7.2 7.3 6.7 3.0 7.4 10.8 7.2 10.1 6.9 10.6 6.9 5.6 5.1 8.4 6.7 8.4 3.1 8.3 8.3 9.1 10.1 8.1 6.4 14.6 7.4 7.6 5.3 8.9 9.2 5.1 4.6 3.8 4.8 7.8 4.5 12.1 3.5 5.6 12.2 7.3 4.7 9.0 6.8 8.0 7.1 9.8 4.0 12.9 11.3 9.2 6.9 4.7 4.5 3.3 8.2 9.3 5.6 5.5 0.0 0.2 0.4 0.1 0.2 0.2 0.2 0.2 0.2 0.2 0.3 0.1 0.1 0.0 0.3 0.0 4.8 0.4 0.2 4.8 6.3 5.8 5.5 4.5 5.1 6.4 6.1 5.9 5.0 7.8 6.5 4.4 0.0 9.0 19.9 4.6 2.8 1.8 3.1 6.8 11.6 4.6 3.6 5.8 7.2 4.1 3.7 50.1 2.8 9.6 6.1 0.0 3.9 2.0 4.2 3.7 5.0 3.5 3.8 20.5 2.8 2.4 4.0 5.1 5.2 0.0 6.5 7.1 4.9 9.7 16.8 19.0 3.4 2.0 6.3 6.1 3.1 2.8 8.0 3.6 8.4 7.5 6.9 7.2 16.6 22.1 4.0 6.2 2.2 7.3 2.5 5.0 2.7 4.1 126.3 6.6 7.5 4.0 1.2 1.6 6.9 7.2 4.0 3.8 3.6 3.4 1.9 ZFYVE27 "FLJ32919, SPG33" ENSG00000155256 "Zinc finger FYVE-type containing 27" Q5T4F4 10 97737121-97760907 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037523, HPA069876" Approved Approved Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 10: Basophils - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 9: Photoreceptor cells - Phototransduction" "Nucleoplasm, Vesicles" Cytosol "HPA037523: AB_10672351, HPA069876: AB_2686218" "unprognostic (2.21e-1)" "unprognostic (1.91e-1)" "prognostic unfavorable (6.91e-4)" "unprognostic (3.12e-1)" "unprognostic (3.42e-2)" "unprognostic (9.76e-2)" "unprognostic (1.22e-1)" "unprognostic (2.30e-2)" "unprognostic (2.48e-2)" "unprognostic (7.15e-2)" "unprognostic (2.05e-3)" "unprognostic (5.24e-2)" "unprognostic (3.38e-3)" "prognostic favorable (7.54e-4)" "unprognostic (4.18e-2)" "unprognostic (1.26e-2)" "prognostic favorable (7.80e-4)" 14.4 27.9 33.1 12.9 32.1 23.2 15.8 29.2 35.9 20.6 34.8 25.6 24.8 16.5 22.9 16.5 20.3 12.1 17.8 35.5 33.6 28.3 32.6 17.7 16.1 32.6 31.4 25.9 23.7 19.2 38.3 9.5 33.2 22.0 16.3 28.4 18.9 10.3 12.8 18.2 30.6 8.5 29.1 29.1 19.8 23.0 33.5 12.7 20.4 5.9 13.1 16.8 17.0 32.4 17.7 21.4 12.6 28.1 14.1 9.8 17.2 17.7 18.5 20.3 19.7 19.1 35.9 27.2 19.8 12.8 25.9 38.8 18.4 17.2 10.6 28.3 18.6 12.9 23.1 18.1 18.1 20.9 24.9 16.0 20.4 19.9 15.2 32.4 11.5 22.5 19.6 17.9 15.3 13.8 16.9 39.4 10.3 15.3 16.4 19.2 12.7 13.0 19.5 10.8 10.1 19.7 11.9 9.9 47.2 11.5 21.8 20.5 12.4 10.2 11.9 15.6 34.2 20.6 18.6 14.3 25.3 26.5 11.9 4.8 5.8 9.3 9.6 6.2 8.2 7.1 6.6 7.9 5.4 6.7 7.5 8.3 8.2 6.8 9.2 5.6 9.5 8.3 33.1 32.1 29.2 35.9 35.5 33.6 32.6 31.4 33.2 29.1 33.5 32.4 10.0 3.2 11.4 14.0 22.1 8.2 12.8 11.3 18.8 29.9 11.1 8.9 7.2 14.3 9.7 14.7 58.4 7.4 21.2 33.9 7.9 14.9 5.2 14.3 7.8 11.0 20.3 14.3 33.6 16.0 5.7 10.1 19.4 11.4 14.0 17.3 10.8 10.9 8.2 37.0 35.2 15.6 14.2 8.8 5.7 1.5 9.6 11.0 10.6 16.9 11.2 14.8 15.5 12.5 20.2 13.9 26.1 9.1 13.4 13.8 35.5 8.6 16.6 43.7 19.7 6.7 9.9 8.9 7.6 10.4 5.5 13.5 17.9 10.9 14.7 17.7 ZNF408 FLJ12827 ENSG00000175213 "Zinc finger protein 408" Q9H9D4 11 46701030-46705912 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" DNA-binding "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017892 Uncertain Approved "Centriolar satellite,Cytosol" NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 44: Endometrium - Transcription" "Centriolar satellite, Cytosol" "HPA017892: AB_1859248" "unprognostic (7.54e-2)" "unprognostic (2.41e-1)" "unprognostic (3.02e-3)" "unprognostic (1.20e-1)" "unprognostic (6.87e-2)" "unprognostic (2.19e-1)" "prognostic unfavorable (6.59e-5)" "unprognostic (3.01e-2)" "unprognostic (6.89e-2)" "unprognostic (1.42e-1)" "unprognostic (7.13e-3)" "unprognostic (5.77e-2)" "unprognostic (3.38e-2)" "unprognostic (9.99e-3)" "unprognostic (9.24e-2)" "unprognostic (1.19e-1)" "unprognostic (2.09e-2)" 5.9 5.1 6.2 4.0 6.6 14.5 5.6 6.8 7.8 6.4 4.7 6.6 5.1 7.8 1.6 8.6 5.7 4.0 6.6 5.9 5.8 5.9 12.7 3.9 5.3 6.7 6.4 5.7 6.5 3.2 5.3 3.7 6.1 7.2 2.8 1.2 5.7 4.3 10.3 10.1 6.6 3.4 6.1 7.5 7.4 5.9 6.5 5.4 5.3 6.2 3.3 7.2 5.9 6.8 4.8 11.4 5.2 9.4 6.5 5.7 13.5 6.3 8.8 12.5 9.1 10.3 5.3 7.4 5.7 7.6 9.0 12.2 6.7 12.4 4.4 5.9 13.5 7.1 8.0 12.7 12.2 7.4 9.7 11.2 12.0 6.3 9.0 6.7 6.2 11.1 11.4 6.5 5.2 15.5 9.0 15.1 21.8 15.9 13.8 9.8 7.8 11.7 6.7 12.5 7.3 9.8 12.1 15.0 10.0 4.8 13.1 12.9 7.1 12.2 8.1 10.2 12.4 9.4 8.8 10.9 7.9 8.5 9.9 3.9 7.6 7.8 8.5 8.3 6.6 6.3 8.3 10.2 7.2 7.6 9.2 7.0 7.1 5.8 6.3 5.7 8.1 7.3 6.2 6.6 6.8 7.8 5.9 5.8 6.7 6.4 6.1 6.1 6.5 6.8 4.6 6.4 2.2 1.6 7.5 6.6 5.5 12.0 7.4 5.1 6.4 5.5 5.3 4.3 5.7 1.8 0.0 10.1 8.5 9.6 11.7 7.8 5.6 7.0 7.2 4.8 8.4 11.4 1.4 4.8 7.7 4.5 6.6 14.9 0.0 8.2 5.3 9.2 5.5 3.3 1.6 9.4 2.0 7.1 2.8 3.2 6.2 3.2 10.6 1.9 6.6 7.9 8.2 1.5 2.1 5.9 3.2 6.4 5.2 4.5 9.0 5.8 4.3 3.5 13.1 3.7 7.2 11.2 9.0 7.5 4.1 10.5 4.8 5.7 7.1 6.0 ZNF513 "FLJ32203, RP58, Zfp513" ENSG00000163795 "Zinc finger protein 513" Q8N8E2 2 27377235-27380790 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Sensory transduction, Transcription, Transcription regulation, Vision" DNA-binding "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 44.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "SH-SY5Y: 50.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA051493 Uncertain NA NA "Cluster 10: Basophils - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 34: Spermatids - Unknown function" "HPA051493: AB_2681505" "unprognostic (1.11e-1)" "unprognostic (1.68e-1)" "unprognostic (4.67e-3)" "unprognostic (1.16e-1)" "unprognostic (2.99e-1)" "unprognostic (2.00e-1)" "prognostic unfavorable (6.21e-5)" "unprognostic (2.86e-2)" "unprognostic (3.70e-2)" "unprognostic (1.00e-1)" "unprognostic (9.48e-3)" "unprognostic (1.18e-1)" "unprognostic (5.18e-3)" "unprognostic (9.31e-2)" "unprognostic (1.79e-1)" "unprognostic (1.75e-1)" "unprognostic (1.01e-3)" 16.2 23.7 15.7 12.7 15.0 12.1 16.7 17.5 19.2 16.6 12.6 22.5 18.7 18.2 5.7 23.8 16.7 9.3 14.3 15.2 14.2 27.3 38.5 18.2 11.1 15.5 15.4 13.4 20.5 10.1 30.2 6.6 14.4 25.8 7.8 4.8 18.7 10.6 11.4 19.5 23.6 7.1 14.1 27.2 24.2 36.1 16.6 8.7 23.5 5.4 6.5 19.4 17.2 15.1 10.3 12.4 15.7 16.0 10.3 8.6 20.6 13.1 15.1 9.6 8.3 10.2 7.6 3.5 11.6 9.4 10.1 9.1 6.7 11.8 2.8 13.0 11.0 9.9 8.9 7.7 18.3 3.4 26.6 14.7 13.0 9.5 11.5 6.3 11.4 13.8 6.2 2.1 9.2 3.9 6.4 16.6 23.7 9.9 8.0 8.2 11.7 6.6 13.5 17.8 9.7 50.8 6.4 7.4 12.9 8.5 5.5 9.8 10.9 6.7 4.4 5.5 3.9 30.1 19.9 6.6 9.3 8.0 13.5 1.2 0.5 1.0 0.4 1.0 0.0 0.0 0.4 0.1 0.7 0.1 0.4 0.2 0.8 0.0 0.5 0.7 0.0 0.3 15.7 15.0 17.5 19.2 15.2 14.2 15.5 15.4 14.4 14.1 16.6 15.1 7.2 3.2 7.5 4.9 2.5 9.2 6.0 5.7 10.2 7.9 10.3 6.9 0.4 10.0 4.3 5.5 4.2 5.6 4.0 14.8 0.0 6.2 44.1 9.0 8.9 7.7 8.4 4.4 4.5 10.2 4.7 4.9 22.4 11.5 0.0 6.9 2.5 10.8 6.0 5.0 5.1 10.6 6.1 2.9 4.6 10.5 4.1 5.3 5.4 1.9 5.9 11.7 2.1 3.0 3.7 9.0 13.5 3.4 4.8 11.0 9.2 5.2 4.7 6.5 6.6 5.6 6.2 9.3 10.3 12.2 13.4 16.1 4.5 10.8 9.4 13.6 ZNF644 "BM-005, KIAA1221, MGC60165, MGC70410" ENSG00000122482 "Zinc finger protein 644" Q9H582 1 90915298-91022272 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" DNA-binding "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 262.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA057795 Uncertain Uncertain Vesicles NA NA "Cluster 6: Non-specific - Transcription" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Vesicles "HPA057795: AB_2683529" "unprognostic (8.20e-2)" "unprognostic (5.86e-3)" "prognostic favorable (4.27e-4)" "prognostic unfavorable (8.39e-4)" "unprognostic (3.19e-3)" "unprognostic (4.62e-3)" "unprognostic (8.04e-2)" "unprognostic (7.01e-2)" "unprognostic (2.44e-2)" "unprognostic (6.32e-2)" "unprognostic (1.70e-1)" "unprognostic (1.16e-1)" "unprognostic (2.61e-2)" "unprognostic (3.03e-1)" "unprognostic (5.09e-2)" "unprognostic (1.03e-1)" "unprognostic (3.07e-1)" 12.4 9.8 17.4 11.7 23.4 17.3 17.1 24.5 22.3 15.7 13.3 13.3 8.5 17.2 11.4 10.3 10.9 10.2 10.0 15.3 18.0 11.0 19.8 10.3 15.9 19.0 20.8 14.7 9.6 12.6 7.9 13.2 19.4 11.6 13.4 11.2 15.4 10.4 14.5 10.4 10.5 12.2 18.8 13.2 10.5 13.1 18.6 19.7 18.7 17.4 15.3 13.5 12.1 28.4 24.1 11.2 32.0 17.1 14.9 17.1 19.4 21.0 21.1 22.1 24.1 15.4 8.3 29.0 23.2 15.6 29.3 19.1 31.6 23.7 33.4 21.5 19.8 38.3 21.8 21.1 20.6 34.6 11.9 16.3 27.0 22.4 30.1 20.8 23.8 21.6 26.8 32.0 23.6 9.5 27.9 30.0 30.3 12.5 22.7 28.7 52.3 16.6 23.5 21.5 25.8 20.6 24.5 19.1 55.2 21.7 12.4 33.7 19.0 24.5 21.3 20.4 31.9 24.5 17.8 39.7 10.3 25.8 12.9 5.4 3.5 4.0 4.6 3.6 5.3 6.8 5.0 5.3 4.4 5.2 6.4 5.5 1.1 9.9 3.8 5.4 4.4 2.6 17.4 23.4 24.5 22.3 15.3 18.0 19.0 20.8 19.4 18.8 18.6 28.4 72.6 70.5 30.0 98.9 85.9 54.2 98.9 45.0 48.3 37.3 49.8 45.0 51.2 28.6 47.0 11.0 25.0 25.6 85.2 34.3 31.3 31.1 11.4 87.3 68.7 44.9 55.0 30.9 96.0 22.6 19.6 51.8 43.8 107.9 43.2 51.9 27.1 26.1 22.5 55.5 106.2 30.4 36.7 29.2 38.6 13.3 46.6 49.7 35.6 124.6 30.7 40.2 38.1 144.3 262.3 29.6 29.2 34.6 79.6 58.8 22.2 29.2 41.7 36.8 52.6 83.5 67.4 51.5 49.2 39.8 47.5 12.0 72.9 44.5 34.0 75.2 ZNHIT3 "Hit1, TRIP3" ENSG00000273611 "Zinc finger HIT-type containing 3" Q15649 17 36486629-36499310 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Disease variant, Epilepsy, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 222.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA060019, HPA078211" Approved Approved Mitochondria NA NA "Cluster 30: Non-specific - Translation" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 29: Early spermatids - Spermatogenesis" Mitochondria "HPA060019: AB_2684188, HPA078211: " "unprognostic (5.47e-2)" "unprognostic (1.29e-1)" "unprognostic (8.87e-2)" "unprognostic (1.20e-1)" "unprognostic (3.56e-2)" "unprognostic (1.56e-1)" "unprognostic (4.75e-3)" "unprognostic (6.03e-2)" "unprognostic (6.48e-3)" "unprognostic (2.55e-1)" "unprognostic (1.39e-1)" "unprognostic (1.93e-1)" "unprognostic (2.81e-2)" "unprognostic (1.47e-1)" "unprognostic (2.20e-1)" "unprognostic (1.84e-1)" "unprognostic (6.19e-2)" 27.4 32.4 33.4 17.6 34.9 31.2 32.7 33.6 43.1 26.2 31.3 30.9 24.1 24.6 39.9 30.4 24.0 20.1 27.2 33.9 35.1 35.1 35.9 19.4 39.1 33.5 34.0 31.1 33.1 27.4 24.0 21.0 33.9 26.3 30.5 19.5 26.3 20.0 58.0 30.9 24.1 18.9 35.2 25.5 28.2 50.4 33.4 29.4 28.7 32.4 39.7 30.0 26.5 35.6 39.6 39.0 70.4 55.1 38.6 49.4 38.8 35.8 56.0 53.6 55.2 6.9 55.7 67.3 38.8 18.0 66.8 37.1 25.7 30.8 66.5 35.3 25.7 27.2 41.1 54.3 28.2 73.0 37.7 34.4 69.0 22.1 53.6 60.3 37.1 79.6 48.5 39.8 58.3 36.0 98.3 92.5 50.1 38.0 38.0 33.0 71.2 56.1 67.7 35.2 57.6 42.7 42.7 26.3 73.0 59.5 76.3 72.7 36.4 25.2 42.6 50.9 54.3 41.3 57.6 68.8 54.6 44.3 50.5 15.7 14.5 10.3 15.5 11.3 32.4 22.6 27.1 21.5 20.0 21.6 33.9 27.6 7.9 23.8 26.5 20.0 27.2 17.2 33.4 34.9 33.6 43.1 33.9 35.1 33.5 34.0 33.9 35.2 33.4 35.6 29.0 25.6 27.0 7.5 48.3 46.4 34.1 99.9 38.1 25.4 51.2 75.2 11.8 30.0 47.5 33.1 12.5 93.2 58.1 24.4 88.0 61.1 222.2 37.9 29.9 32.3 43.5 33.9 10.9 51.2 98.5 30.9 21.4 32.3 34.2 48.5 25.4 30.4 67.4 15.2 12.7 33.8 42.7 49.4 36.7 79.1 37.0 34.6 53.4 10.3 66.6 42.5 47.4 12.1 14.7 60.9 36.8 44.4 32.4 47.3 50.6 88.1 33.8 28.3 46.0 36.6 37.5 179.1 71.2 37.2 43.8 77.2 58.3 55.9 44.6 34.0