Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific nTPM" "RNA single cell type specificity" "RNA single cell type distribution" "RNA single cell type specificity score" "RNA single cell type specific nTPM" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific nTPM" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific nTPM" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific nTPM" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific nTPM" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific nTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific nTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "CCD Protein" "CCD Transcript" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Blood expression cluster" "Tissue expression cluster" "Cell line expression cluster" "Single cell expression cluster" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [nTPM]" "Tissue RNA - adrenal gland [nTPM]" "Tissue RNA - amygdala [nTPM]" "Tissue RNA - appendix [nTPM]" "Tissue RNA - basal ganglia [nTPM]" "Tissue RNA - bone marrow [nTPM]" "Tissue RNA - breast [nTPM]" "Tissue RNA - cerebellum [nTPM]" "Tissue RNA - cerebral cortex [nTPM]" "Tissue RNA - cervix [nTPM]" "Tissue RNA - choroid plexus [nTPM]" "Tissue RNA - colon [nTPM]" "Tissue RNA - duodenum [nTPM]" "Tissue RNA - endometrium 1 [nTPM]" "Tissue RNA - epididymis [nTPM]" "Tissue RNA - esophagus [nTPM]" "Tissue RNA - fallopian tube [nTPM]" "Tissue RNA - gallbladder [nTPM]" "Tissue RNA - heart muscle [nTPM]" "Tissue RNA - hippocampal formation [nTPM]" "Tissue RNA - hypothalamus [nTPM]" "Tissue RNA - kidney [nTPM]" "Tissue RNA - liver [nTPM]" "Tissue RNA - lung [nTPM]" "Tissue RNA - lymph node [nTPM]" "Tissue RNA - medulla oblongata [nTPM]" "Tissue RNA - midbrain [nTPM]" "Tissue RNA - ovary [nTPM]" "Tissue RNA - pancreas [nTPM]" "Tissue RNA - parathyroid gland [nTPM]" "Tissue RNA - pituitary gland [nTPM]" "Tissue RNA - placenta [nTPM]" "Tissue RNA - pons [nTPM]" "Tissue RNA - prostate [nTPM]" "Tissue RNA - rectum [nTPM]" "Tissue RNA - retina [nTPM]" "Tissue RNA - salivary gland [nTPM]" "Tissue RNA - seminal vesicle [nTPM]" "Tissue RNA - skeletal muscle [nTPM]" "Tissue RNA - skin 1 [nTPM]" "Tissue RNA - small intestine [nTPM]" "Tissue RNA - smooth muscle [nTPM]" "Tissue RNA - spinal cord [nTPM]" "Tissue RNA - spleen [nTPM]" "Tissue RNA - stomach 1 [nTPM]" "Tissue RNA - testis [nTPM]" "Tissue RNA - thalamus [nTPM]" "Tissue RNA - thymus [nTPM]" "Tissue RNA - thyroid gland [nTPM]" "Tissue RNA - tongue [nTPM]" "Tissue RNA - tonsil [nTPM]" "Tissue RNA - urinary bladder [nTPM]" "Tissue RNA - vagina [nTPM]" "Tissue RNA - white matter [nTPM]" "Cell RNA - A-431 [nTPM]" "Cell RNA - A549 [nTPM]" "Cell RNA - AF22 [nTPM]" "Cell RNA - AN3-CA [nTPM]" "Cell RNA - ASC diff [nTPM]" "Cell RNA - ASC TERT1 [nTPM]" "Cell RNA - BEWO [nTPM]" "Cell RNA - BJ [nTPM]" "Cell RNA - BJ hTERT+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]" "Cell RNA - CACO-2 [nTPM]" "Cell RNA - CAPAN-2 [nTPM]" "Cell RNA - Daudi [nTPM]" "Cell RNA - EFO-21 [nTPM]" "Cell RNA - fHDF/TERT166 [nTPM]" "Cell RNA - GAMG [nTPM]" "Cell RNA - HaCaT [nTPM]" "Cell RNA - HAP1 [nTPM]" "Cell RNA - HBEC3-KT [nTPM]" "Cell RNA - HBF TERT88 [nTPM]" "Cell RNA - HDLM-2 [nTPM]" "Cell RNA - HEK 293 [nTPM]" "Cell RNA - HEL [nTPM]" "Cell RNA - HeLa [nTPM]" "Cell RNA - Hep G2 [nTPM]" "Cell RNA - HHSteC [nTPM]" "Cell RNA - HL-60 [nTPM]" "Cell RNA - HMC-1 [nTPM]" "Cell RNA - HSkMC [nTPM]" "Cell RNA - hTCEpi [nTPM]" "Cell RNA - hTEC/SVTERT24-B [nTPM]" "Cell RNA - hTERT-HME1 [nTPM]" "Cell RNA - hTERT-RPE1 [nTPM]" "Cell RNA - HUVEC TERT2 [nTPM]" "Cell RNA - JURKAT [nTPM]" "Cell RNA - K-562 [nTPM]" "Cell RNA - Karpas-707 [nTPM]" "Cell RNA - LHCN-M2 [nTPM]" "Cell RNA - MCF7 [nTPM]" "Cell RNA - MOLT-4 [nTPM]" "Cell RNA - NB-4 [nTPM]" "Cell RNA - NTERA-2 [nTPM]" "Cell RNA - OE19 [nTPM]" "Cell RNA - PC-3 [nTPM]" "Cell RNA - REH [nTPM]" "Cell RNA - RH-30 [nTPM]" "Cell RNA - RPMI-8226 [nTPM]" "Cell RNA - RPTEC TERT1 [nTPM]" "Cell RNA - RT4 [nTPM]" "Cell RNA - SCLC-21H [nTPM]" "Cell RNA - SH-SY5Y [nTPM]" "Cell RNA - SiHa [nTPM]" "Cell RNA - SK-BR-3 [nTPM]" "Cell RNA - SK-MEL-30 [nTPM]" "Cell RNA - SuSa [nTPM]" "Cell RNA - T-47d [nTPM]" "Cell RNA - THP-1 [nTPM]" "Cell RNA - TIME [nTPM]" "Cell RNA - U-138 MG [nTPM]" "Cell RNA - U-2 OS [nTPM]" "Cell RNA - U-2197 [nTPM]" "Cell RNA - U-251 MG [nTPM]" "Cell RNA - U-266/70 [nTPM]" "Cell RNA - U-266/84 [nTPM]" "Cell RNA - U-698 [nTPM]" "Cell RNA - U-87 MG [nTPM]" "Cell RNA - U-937 [nTPM]" "Cell RNA - WM-115 [nTPM]" "Blood RNA - basophil [nTPM]" "Blood RNA - classical monocyte [nTPM]" "Blood RNA - eosinophil [nTPM]" "Blood RNA - gdT-cell [nTPM]" "Blood RNA - intermediate monocyte [nTPM]" "Blood RNA - MAIT T-cell [nTPM]" "Blood RNA - memory B-cell [nTPM]" "Blood RNA - memory CD4 T-cell [nTPM]" "Blood RNA - memory CD8 T-cell [nTPM]" "Blood RNA - myeloid DC [nTPM]" "Blood RNA - naive B-cell [nTPM]" "Blood RNA - naive CD4 T-cell [nTPM]" "Blood RNA - naive CD8 T-cell [nTPM]" "Blood RNA - neutrophil [nTPM]" "Blood RNA - NK-cell [nTPM]" "Blood RNA - non-classical monocyte [nTPM]" "Blood RNA - plasmacytoid DC [nTPM]" "Blood RNA - T-reg [nTPM]" "Blood RNA - total PBMC [nTPM]" "Brain RNA - amygdala [nTPM]" "Brain RNA - basal ganglia [nTPM]" "Brain RNA - cerebellum [nTPM]" "Brain RNA - cerebral cortex [nTPM]" "Brain RNA - hippocampal formation [nTPM]" "Brain RNA - hypothalamus [nTPM]" "Brain RNA - medulla oblongata [nTPM]" "Brain RNA - midbrain [nTPM]" "Brain RNA - pons [nTPM]" "Brain RNA - spinal cord [nTPM]" "Brain RNA - thalamus [nTPM]" "Brain RNA - white matter [nTPM]" "Single Cell Type RNA - Adipocytes [nTPM]" "Single Cell Type RNA - Alveolar cells type 1 [nTPM]" "Single Cell Type RNA - Alveolar cells type 2 [nTPM]" "Single Cell Type RNA - Astrocytes [nTPM]" "Single Cell Type RNA - B-cells [nTPM]" "Single Cell Type RNA - Basal keratinocytes [nTPM]" "Single Cell Type RNA - Basal prostatic cells [nTPM]" "Single Cell Type RNA - Basal respiratory cells [nTPM]" "Single Cell Type RNA - Basal squamous epithelial cells [nTPM]" "Single Cell Type RNA - Bipolar cells [nTPM]" "Single Cell Type RNA - Breast glandular cells [nTPM]" "Single Cell Type RNA - Breast myoepithelial cells [nTPM]" "Single Cell Type RNA - Cardiomyocytes [nTPM]" "Single Cell Type RNA - Cholangiocytes [nTPM]" "Single Cell Type RNA - Club cells [nTPM]" "Single Cell Type RNA - Collecting duct cells [nTPM]" "Single Cell Type RNA - Cone photoreceptor cells [nTPM]" "Single Cell Type RNA - Cytotrophoblasts [nTPM]" "Single Cell Type RNA - dendritic cells [nTPM]" "Single Cell Type RNA - Distal enterocytes [nTPM]" "Single Cell Type RNA - Distal tubular cells [nTPM]" "Single Cell Type RNA - Ductal cells [nTPM]" "Single Cell Type RNA - Early spermatids [nTPM]" "Single Cell Type RNA - Endometrial ciliated cells [nTPM]" "Single Cell Type RNA - Endometrial stromal cells [nTPM]" "Single Cell Type RNA - Endothelial cells [nTPM]" "Single Cell Type RNA - Enteroendocrine cells [nTPM]" "Single Cell Type RNA - Erythroid cells [nTPM]" "Single Cell Type RNA - Excitatory neurons [nTPM]" "Single Cell Type RNA - Exocrine glandular cells [nTPM]" "Single Cell Type RNA - Extravillous trophoblasts [nTPM]" "Single Cell Type RNA - Fibroblasts [nTPM]" "Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]" "Single Cell Type RNA - Glandular and luminal cells [nTPM]" "Single Cell Type RNA - granulocytes [nTPM]" "Single Cell Type RNA - Granulosa cells [nTPM]" "Single Cell Type RNA - Hepatic stellate cells [nTPM]" "Single Cell Type RNA - Hepatocytes [nTPM]" "Single Cell Type RNA - Hofbauer cells [nTPM]" "Single Cell Type RNA - Horizontal cells [nTPM]" "Single Cell Type RNA - Inhibitory neurons [nTPM]" "Single Cell Type RNA - Intestinal goblet cells [nTPM]" "Single Cell Type RNA - Ionocytes [nTPM]" "Single Cell Type RNA - Kupffer cells [nTPM]" "Single Cell Type RNA - Langerhans cells [nTPM]" "Single Cell Type RNA - Late spermatids [nTPM]" "Single Cell Type RNA - Leydig cells [nTPM]" "Single Cell Type RNA - Macrophages [nTPM]" "Single Cell Type RNA - Melanocytes [nTPM]" "Single Cell Type RNA - Microglial cells [nTPM]" "Single Cell Type RNA - monocytes [nTPM]" "Single Cell Type RNA - Muller glia cells [nTPM]" "Single Cell Type RNA - NK-cells [nTPM]" "Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]" "Single Cell Type RNA - Oligodendrocytes [nTPM]" "Single Cell Type RNA - Pancreatic endocrine cells [nTPM]" "Single Cell Type RNA - Paneth cells [nTPM]" "Single Cell Type RNA - Peritubular cells [nTPM]" "Single Cell Type RNA - Plasma cells [nTPM]" "Single Cell Type RNA - Prostatic glandular cells [nTPM]" "Single Cell Type RNA - Proximal enterocytes [nTPM]" "Single Cell Type RNA - Proximal tubular cells [nTPM]" "Single Cell Type RNA - Respiratory ciliated cells [nTPM]" "Single Cell Type RNA - Rod photoreceptor cells [nTPM]" "Single Cell Type RNA - Sertoli cells [nTPM]" "Single Cell Type RNA - Skeletal myocytes [nTPM]" "Single Cell Type RNA - Smooth muscle cells [nTPM]" "Single Cell Type RNA - Spermatocytes [nTPM]" "Single Cell Type RNA - Spermatogonia [nTPM]" "Single Cell Type RNA - Squamous epithelial cells [nTPM]" "Single Cell Type RNA - Suprabasal keratinocytes [nTPM]" "Single Cell Type RNA - Syncytiotrophoblasts [nTPM]" "Single Cell Type RNA - T-cells [nTPM]" "Single Cell Type RNA - Theca cells [nTPM]" "Single Cell Type RNA - Undifferentiated cells [nTPM]" "Single Cell Type RNA - Urothelial cells [nTPM]" ABHD4 FLJ12816 ENSG00000100439 "Abhydrolase domain containing 4, N-acyl phospholipase B" Q8TB40 14 22598237-22613215 "Enzymes, Predicted intracellular proteins" "Lipid degradation, Lipid metabolism" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Syncytiotrophoblasts: 26.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 35.4" "Lineage enriched" "Detected in all" 4 "granulocytes: 35.4" "Cell line enhanced" "Detected in many" "ASC diff: 121.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000600 Uncertain Approved Nucleoplasm NA NA "Cluster 38: Basophils - Unknown function" "Cluster 27: Brain & Skin - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 44: Endometrium - Transcription" Nucleoplasm "HPA000600: AB_1078081" "unprognostic (5.04e-2)" "unprognostic (5.15e-2)" "unprognostic (2.68e-3)" "unprognostic (8.17e-2)" "unprognostic (1.17e-1)" "unprognostic (5.24e-2)" "unprognostic (1.19e-3)" "unprognostic (3.69e-2)" "unprognostic (1.28e-1)" "unprognostic (5.72e-2)" "unprognostic (1.32e-3)" "unprognostic (3.73e-1)" "unprognostic (1.56e-2)" "unprognostic (5.18e-2)" "unprognostic (1.37e-1)" "unprognostic (4.51e-2)" "unprognostic (1.03e-2)" 22.8 28.7 21.6 7.3 23.6 12.6 17.5 22.3 22.4 25.9 27.7 19.2 15.0 26.3 27.4 38.3 15.4 24.7 20.5 21.0 24.5 25.3 22.6 17.6 8.0 27.8 24.5 15.9 14.5 22.8 12.8 17.9 23.3 19.3 13.8 21.7 16.5 33.7 25.5 18.9 17.9 24.5 22.5 14.8 24.9 36.8 24.2 10.1 21.6 27.2 14.8 24.8 26.2 26.0 23.4 38.5 15.5 14.2 121.8 44.0 14.9 10.3 52.2 25.3 46.8 23.5 36.4 2.2 26.7 45.2 27.2 44.5 9.9 26.6 20.6 17.3 3.5 8.7 28.1 77.9 55.6 1.4 30.3 56.1 20.6 33.2 28.2 52.7 26.4 16.0 6.5 41.1 23.5 12.8 0.7 1.3 18.8 94.4 27.7 6.5 13.8 9.8 29.6 24.6 1.0 3.1 69.1 24.3 27.2 30.6 9.5 2.6 18.8 11.0 14.9 18.0 4.1 44.1 25.3 0.8 8.2 1.8 8.9 35.4 6.3 10.2 8.2 4.7 6.8 5.5 5.4 5.5 4.2 3.1 1.7 3.5 25.7 7.3 4.6 0.6 3.4 5.6 21.6 23.6 22.3 22.4 21.0 24.5 27.8 24.5 23.3 22.5 24.2 26.0 5.0 12.8 5.6 2.6 4.7 3.2 7.0 5.2 7.4 3.5 6.2 6.6 6.7 11.5 3.4 3.7 4.2 6.1 4.8 9.8 9.8 13.3 3.1 8.3 6.0 6.5 6.0 4.4 1.1 11.7 2.3 5.2 16.3 12.5 5.1 5.2 9.3 10.3 7.8 8.4 1.2 6.8 4.1 6.9 1.7 4.7 5.6 4.6 1.8 1.0 9.4 6.9 5.2 4.0 3.7 9.8 9.3 8.2 12.4 9.5 13.3 4.7 2.6 3.2 6.6 3.1 6.0 0.7 0.5 13.2 2.7 26.8 5.0 9.7 3.3 11.7 ABHD5 "CGI-58, NCIE2" ENSG00000011198 "Abhydrolase domain containing 5, lysophosphatidic acid acyltransferase" Q8WTS1 3 43690108-43734371 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Differentiation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Cataract, Deafness, Disease variant, Ichthyosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Syncytiotrophoblasts: 205.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 67.8;neutrophil: 42.5" "Lineage enriched" "Detected in all" 5 "granulocytes: 67.8" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB020685, HPA035851, HPA035852" Approved Supported Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 44: HDLM-2 - Immune response" "Cluster 7: Non-specific - Mitochondria" "Vesicles, Cytosol" Nucleoplasm "CAB020685: , HPA035851: AB_10671942, HPA035852: AB_10672073" "unprognostic (2.58e-1)" "unprognostic (2.73e-1)" "prognostic favorable (8.89e-4)" "unprognostic (1.07e-1)" "unprognostic (1.75e-2)" "unprognostic (2.26e-1)" "unprognostic (6.13e-2)" "unprognostic (2.40e-2)" "unprognostic (5.33e-2)" "unprognostic (3.50e-3)" "unprognostic (2.56e-2)" "unprognostic (4.13e-3)" "prognostic favorable (9.17e-5)" "unprognostic (2.48e-1)" "unprognostic (8.87e-2)" "unprognostic (4.18e-2)" "unprognostic (4.18e-2)" 38.8 12.5 6.7 8.5 8.6 39.6 27.9 10.5 8.9 9.8 6.0 12.3 9.9 5.7 4.1 31.1 5.1 11.6 13.4 6.8 7.4 12.0 21.7 16.4 3.4 9.2 8.2 4.6 16.0 12.2 5.6 10.2 9.1 7.1 7.5 6.3 27.4 8.4 15.0 38.0 10.5 9.3 9.3 9.4 12.1 10.8 8.4 6.8 15.5 18.5 7.9 16.7 16.9 11.9 18.9 6.8 8.2 9.7 32.0 12.8 17.1 77.4 27.1 18.8 14.9 9.4 6.4 16.2 10.9 23.2 15.8 5.8 16.5 18.5 22.6 58.4 13.2 36.6 24.4 7.5 15.7 9.2 13.2 13.0 64.6 31.3 28.5 18.8 33.3 10.8 23.9 14.2 46.9 11.0 7.6 6.9 22.8 16.7 20.4 3.1 24.1 8.6 27.9 40.4 10.6 13.6 36.9 20.5 9.8 9.8 18.9 8.9 19.3 18.1 13.6 35.0 34.5 11.1 34.0 7.7 20.3 17.3 16.0 67.8 14.7 9.5 2.3 7.9 1.7 3.5 1.7 2.7 6.8 4.0 1.6 2.5 42.5 2.0 5.7 1.9 4.8 5.3 6.7 8.6 10.5 8.9 6.8 7.4 9.2 8.2 9.1 9.3 8.4 11.9 117.5 25.6 51.8 12.7 44.8 39.9 27.5 25.9 88.8 11.9 149.9 116.2 10.3 14.3 49.6 27.6 27.1 16.7 80.3 65.0 33.2 57.5 19.5 47.5 49.0 34.6 36.2 69.0 24.1 61.5 24.9 53.7 67.8 114.0 16.5 8.8 18.2 12.7 18.0 3.3 24.1 23.7 34.6 44.1 17.4 17.1 5.3 79.8 7.2 11.2 35.9 11.0 12.3 18.1 28.8 75.2 49.8 5.7 41.8 25.5 98.5 39.8 19.1 17.4 0.0 32.0 46.4 47.3 41.9 111.7 40.9 205.4 42.6 15.2 21.9 71.6 ACE "ACE1, CD143, DCP1" ENSG00000159640 "Angiotensin I converting enzyme" P12821 17 63477061-63498380 "Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 265.1;testis: 101.9" "Group enriched" "Detected in many" 20 "Early spermatids: 543.6;Late spermatids: 1322.9;Proximal enterocytes: 1172.8" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "basal ganglia: 8.1" "Immune cell enhanced" "Detected in single" "memory B-cell: 1.0" "Low lineage specificity" "Detected in single" "Group enriched" "Detected in many" 4 "ASC TERT1: 63.3;HUVEC TERT2: 33.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002426, CAB002921, HPA029298, HPA069790" Enhanced Approved Vesicles "Secreted to blood" NA NA 104000000 170000000 "Cluster 43: B-cells - Humoral immune response" "Cluster 56: Intestine - Transmembrane transport" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 45: Enterocytes - Digestion" Vesicles "CAB002426: AB_442052, CAB002921: , HPA029298: AB_10960255, HPA069790: AB_2686197" "unprognostic (4.72e-2)" "unprognostic (4.16e-1)" "unprognostic (1.93e-3)" "unprognostic (6.06e-2)" "unprognostic (2.78e-1)" "unprognostic (1.35e-2)" "unprognostic (4.37e-1)" "unprognostic (1.54e-1)" "unprognostic (1.56e-1)" "unprognostic (1.25e-2)" "unprognostic (3.13e-2)" "unprognostic (2.38e-1)" "unprognostic (7.66e-2)" "unprognostic (9.07e-2)" "unprognostic (1.66e-1)" "unprognostic (1.08e-1)" "unprognostic (2.76e-2)" 13.4 4.9 1.7 4.8 8.1 0.1 8.1 0.2 2.5 18.1 0.5 11.2 176.4 8.1 3.5 4.1 6.3 8.2 10.4 1.3 1.0 10.8 1.9 49.0 4.9 1.3 0.9 1.9 6.2 18.7 9.2 11.6 1.3 8.9 6.1 0.4 7.6 23.8 16.1 3.8 265.1 9.6 0.8 2.8 8.3 101.9 2.0 0.8 19.2 10.0 2.1 5.5 3.8 1.1 0.0 0.0 0.0 0.0 2.6 63.3 0.6 2.4 4.7 0.0 0.0 0.9 5.1 1.3 1.8 11.4 0.1 0.0 3.1 0.0 0.0 0.0 1.4 6.6 0.0 0.0 1.4 0.0 0.0 4.2 0.0 0.1 0.0 1.2 33.8 0.0 5.8 0.0 0.1 1.1 0.0 1.4 0.4 11.7 0.7 0.1 0.5 0.9 0.0 0.0 8.2 5.6 0.0 0.0 0.0 1.3 2.9 0.4 0.0 0.1 0.2 0.5 0.1 0.0 0.0 0.0 1.0 0.0 0.5 0.0 0.0 0.0 0.1 0.1 0.2 1.0 0.5 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 1.7 8.1 0.2 2.5 1.3 1.0 1.3 0.9 1.3 0.8 2.0 1.1 50.0 0.0 3.3 0.0 0.5 1.5 2.6 0.1 1.2 4.0 3.6 1.9 2.1 1.5 0.7 0.0 0.0 0.1 0.3 11.9 0.0 5.9 543.6 10.8 8.0 34.7 18.0 0.0 4.7 0.4 0.1 11.5 2.0 36.3 7.0 24.1 3.6 0.8 4.2 0.0 1.8 39.8 0.0 33.7 3.5 1322.9 4.4 13.6 3.6 4.7 0.0 1.8 0.0 1.0 0.2 0.7 40.9 2.6 0.1 4.2 1172.8 21.7 0.0 1.1 0.0 2.0 4.2 13.5 6.4 0.2 0.1 0.1 2.2 0.3 26.2 2.1 ACE2 ENSG00000130234 "Angiotensin I converting enzyme 2" Q9BYF1 X 15494566-15607236 "Enzymes, Metabolic proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters" "Host-virus interaction" "Carboxypeptidase, Host cell receptor for virus entry, Hydrolase, Metalloprotease, Protease, Receptor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 65.5;intestine: 242.2;kidney: 87.6" "Cell type enriched" "Detected in many" 5 "Proximal enterocytes: 294.8" "Group enriched" "Detected in many" 4 "colorectal cancer: 13.9;renal cancer: 26.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "NB-4: 1.2;NTERA-2: 1.2;SuSa: 1.9" "Low region specificity" "Detected in all" "Not detected" "Not detected" "HPA000288, CAB026174, CAB026213, CAB080024, CAB080025, CAB080027, CAB080028" Enhanced "Secreted to blood" NA NA 400000 "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 5: NTERA-2 - Transcription" "Cluster 45: Enterocytes - Digestion" "CAB026174: , CAB026213: , CAB080024: AB_10864415, CAB080025: AB_2809589, CAB080027: AB_2665870, CAB080028: AB_2665871, HPA000288: AB_1078160" "unprognostic (1.40e-1)" "unprognostic (7.26e-2)" "unprognostic (2.76e-2)" "unprognostic (5.71e-2)" "unprognostic (2.51e-1)" "unprognostic (5.26e-2)" "prognostic favorable (4.21e-4)" "unprognostic (2.34e-2)" "unprognostic (6.74e-3)" "unprognostic (2.54e-3)" "unprognostic (1.00e-1)" "unprognostic (1.74e-1)" "prognostic favorable (2.12e-5)" "unprognostic (1.94e-1)" "unprognostic (9.62e-2)" "unprognostic (2.11e-1)" "unprognostic (7.10e-2)" 8.9 0.5 0.1 1.4 0.1 0.6 4.3 0.4 0.3 0.6 1.9 9.9 183.3 0.5 0.5 1.8 1.5 65.5 42.7 0.2 0.2 87.6 5.7 0.8 0.4 0.2 0.2 1.8 2.5 1.5 0.1 1.2 0.2 0.4 5.9 0.3 1.4 4.1 0.7 0.3 242.2 0.5 0.1 0.1 2.6 49.7 0.2 0.5 4.5 0.5 0.2 0.8 1.2 0.2 0.0 0.0 0.3 0.0 0.2 0.0 0.8 0.1 0.0 0.2 0.2 0.2 0.3 0.4 0.3 0.0 0.3 0.7 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.1 0.0 0.1 0.0 0.2 0.0 0.5 1.2 1.2 0.0 0.0 0.3 0.2 0.5 0.2 0.4 0.2 0.9 0.0 0.4 0.0 1.9 0.4 0.4 0.1 0.0 0.0 0.3 0.4 0.1 0.5 0.5 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.2 0.1 0.1 0.4 0.3 0.2 0.2 0.2 0.2 0.2 0.1 0.2 0.2 0.4 0.0 0.5 1.3 1.4 0.1 0.5 5.0 0.0 0.0 1.6 0.0 11.2 55.8 2.6 0.0 0.0 4.2 0.1 22.9 3.9 1.2 0.5 1.1 0.3 1.0 7.2 0.0 0.8 0.8 0.3 4.6 0.0 0.6 0.0 3.9 0.0 0.9 0.8 0.0 0.8 8.2 0.0 0.0 0.0 1.4 8.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.9 5.1 6.0 0.0 1.0 294.8 48.8 2.0 0.0 19.7 0.0 8.9 1.1 1.0 0.0 0.1 12.7 0.3 0.1 10.6 2.2 ACR ENSG00000100312 Acrosin P10323 22 50738196-50745339 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 29 "testis: 86.7" "Group enriched" "Detected in some" 33 "Early spermatids: 492.2;Late spermatids: 134.8;Spermatocytes: 216.9" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected" "Not detected" HPA048687 Enhanced "Secreted in male reproductive system" NA NA "Cluster 83: Testis - Spermatogenesis" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA048687: AB_2680494" "unprognostic (1.71e-1)" "unprognostic (1.26e-1)" "unprognostic (1.04e-1)" "unprognostic (6.27e-3)" "unprognostic (3.58e-2)" "unprognostic (8.04e-2)" "unprognostic (3.30e-3)" "unprognostic (5.41e-2)" "unprognostic (1.51e-1)" "unprognostic (2.28e-1)" "unprognostic (1.34e-2)" "unprognostic (2.12e-1)" "unprognostic (1.48e-1)" "unprognostic (1.23e-2)" "unprognostic (1.71e-1)" "unprognostic (2.27e-1)" "unprognostic (1.25e-1)" 2.6 0.2 0.4 0.0 0.5 0.0 2.0 0.4 0.5 0.8 2.6 0.5 0.1 1.1 0.7 0.4 1.1 0.2 1.0 0.4 0.3 0.9 0.8 2.0 0.0 0.3 0.3 0.3 0.2 0.0 0.5 0.1 0.5 0.6 0.0 0.1 0.6 0.2 0.8 0.8 0.5 0.2 0.4 3.0 0.3 86.7 0.4 0.0 0.6 0.0 0.0 0.6 0.7 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.5 0.4 0.5 0.4 0.3 0.3 0.3 0.5 0.4 0.4 0.4 8.4 0.0 0.0 0.3 0.0 0.1 0.0 0.0 2.2 0.0 0.3 0.6 0.5 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 492.2 0.4 0.1 4.7 3.0 0.0 0.2 0.0 0.0 0.1 0.0 0.2 0.0 0.0 7.5 0.1 0.1 0.0 0.2 0.8 0.0 0.0 0.0 134.8 3.4 0.2 0.0 0.0 0.0 0.0 0.0 0.5 0.2 0.0 0.8 2.6 0.0 0.0 1.2 0.4 0.0 0.0 6.6 0.3 0.1 216.9 2.5 0.3 0.0 0.0 0.0 0.1 1.5 0.2 ACY1 ENSG00000243989 "Aminoacylase 1" Q03154 3 51983340-51989197 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Hydrolase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 9 "intestine: 181.5;kidney: 449.9;liver: 274.9" "Cell type enhanced" "Detected in many" "Distal enterocytes: 31.6;Gastric mucus-secreting cells: 32.6;Proximal enterocytes: 144.8;Proximal tubular cells: 92.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Hep G2: 128.0" "CAB003695, HPA036174, HPA036175" Enhanced NA NA 23000000 "Cluster 27: Non-specific - Gene expression" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "CAB003695: AB_425286, HPA036174: AB_2674988, HPA036175: AB_2674989" "unprognostic (4.28e-2)" "unprognostic (1.89e-1)" "unprognostic (2.10e-1)" "unprognostic (2.48e-3)" "unprognostic (3.15e-1)" "unprognostic (6.51e-2)" "unprognostic (2.82e-2)" "unprognostic (1.47e-1)" "unprognostic (1.05e-2)" "unprognostic (6.08e-2)" "unprognostic (2.36e-2)" "unprognostic (2.70e-2)" "prognostic favorable (2.93e-4)" "unprognostic (3.57e-1)" "unprognostic (3.75e-1)" "unprognostic (7.88e-2)" "prognostic favorable (6.77e-4)" 19.2 24.0 5.6 7.3 5.7 8.8 20.7 6.4 7.3 13.9 11.6 30.6 181.5 4.3 21.8 10.7 13.0 10.7 14.5 5.1 6.0 449.9 274.9 9.2 7.2 6.5 5.9 4.8 8.7 28.2 4.7 9.7 6.6 14.3 30.5 1.9 16.4 11.1 20.2 8.2 138.2 6.9 6.7 8.1 23.6 3.2 6.1 5.1 21.0 34.6 9.2 12.5 7.1 6.6 15.9 26.2 13.2 34.1 28.9 39.4 40.5 12.6 28.2 29.4 14.9 41.2 67.9 7.2 12.2 22.0 13.2 20.0 14.7 81.2 11.5 21.8 10.7 25.3 13.9 128.0 49.7 19.8 21.0 48.0 67.2 25.4 69.1 25.8 11.5 14.6 47.1 23.9 29.9 35.2 0.6 38.9 23.4 92.1 39.3 8.0 14.1 63.5 74.5 50.8 16.9 18.2 12.6 62.6 29.5 7.5 42.3 27.9 7.1 22.0 21.9 24.8 18.8 61.7 16.9 12.1 28.1 42.9 29.0 9.1 15.7 0.4 10.7 15.1 5.7 7.4 2.6 4.5 21.2 6.1 4.1 4.7 0.0 20.4 6.4 2.8 3.8 9.7 5.6 5.7 6.4 7.3 5.1 6.0 6.5 5.9 6.6 6.7 6.1 6.6 0.5 3.2 3.2 0.0 4.9 0.6 1.0 1.9 17.1 0.2 2.7 1.3 0.2 1.5 2.5 5.5 0.0 3.9 0.3 31.6 9.8 16.6 0.2 0.2 0.9 0.9 2.4 15.8 0.0 8.3 4.5 4.3 32.6 0.6 7.0 0.2 1.1 13.1 1.9 0.0 0.0 11.2 4.1 1.9 0.3 0.8 0.6 4.2 0.0 0.0 9.3 0.8 1.0 0.0 0.0 16.4 23.3 0.0 14.9 0.6 144.8 92.0 1.7 1.1 0.0 0.6 2.0 0.1 0.2 18.5 0.4 4.1 2.6 1.0 14.5 0.4 ADGB "C6orf103, CAPN16, dJ408K24.1, FLJ23121" ENSG00000118492 Androglobin Q8N7X0 6 146598967-146815462 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 5.5;choroid plexus: 6.0;fallopian tube: 7.5;testis: 26.1" "Cell type enhanced" "Detected in some" "Early spermatids: 305.4;Endometrial ciliated cells: 57.1;Late spermatids: 74.8;Respiratory ciliated cells: 92.5;Spermatocytes: 68.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 18 "HDLM-2: 7.0" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA036340, HPA036341" Enhanced Uncertain Nucleoplasm,Mitochondria No NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 49: Ciliated cells - Cilium organization" "Cluster 44: HDLM-2 - Immune response" "Cluster 49: Ciliated cells - Cilium organization" Mitochondria Nucleoplasm "HPA036340: AB_2675071, HPA036341: AB_10672241" "unprognostic (4.15e-3)" "unprognostic (1.23e-2)" "unprognostic (9.30e-3)" "unprognostic (1.09e-1)" "unprognostic (2.07e-2)" "unprognostic (3.11e-2)" "unprognostic (5.05e-1)" "unprognostic (2.34e-1)" "unprognostic (4.83e-3)" "unprognostic (1.05e-1)" "unprognostic (1.93e-1)" "unprognostic (1.77e-2)" "unprognostic (3.66e-2)" "unprognostic (2.68e-1)" 0.0 0.0 0.8 0.0 0.5 0.0 0.0 0.3 0.1 0.4 6.0 0.3 0.0 0.1 0.2 0.0 7.5 0.0 0.0 0.8 0.8 0.0 0.0 1.4 0.0 5.5 3.8 0.0 0.0 0.0 0.3 0.0 2.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 26.1 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.5 0.3 0.1 0.8 0.8 5.5 3.8 2.4 3.0 1.0 1.0 0.0 3.2 1.5 0.7 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.7 0.0 9.5 0.0 4.2 0.0 0.0 0.4 0.0 0.0 305.4 57.1 0.3 0.1 0.0 0.0 0.8 0.0 0.0 0.1 0.0 0.7 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.4 2.0 0.0 1.9 74.8 2.8 0.4 0.0 1.0 0.0 0.2 0.0 0.5 0.2 0.0 0.3 2.6 0.0 0.1 0.0 0.1 92.5 0.1 0.0 0.0 0.9 68.4 3.3 0.0 0.0 0.0 0.1 0.0 0.7 0.0 AEBP1 ACLP ENSG00000106624 "AE binding protein 1" Q8IUX7 7 44104345-44114562 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Transcription, Transcription regulation" "Calmodulin-binding, DNA-binding, Repressor" "Disease variant, Ehlers-Danlos syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 103.0;Fibroblasts: 263.2;Leydig cells: 151.6;Peritubular cells: 508.9;Smooth muscle cells: 173.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 5 "plasmacytoid DC: 7.6" "Lineage enriched" "Detected in many" 5 "dendritic cells: 7.6" "Cell line enhanced" "Detected in many" "ASC diff: 141.1;BJ: 193.0;BJ hTERT+: 126.0;fHDF/TERT166: 208.9;JURKAT: 145.0;WM-115: 117.9" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "spinal cord: 57.6" "CAB009966, HPA047724, HPA063595, HPA064970" Supported Supported Nucleoplasm,Vesicles,Cytosol "Secreted - unknown location" NA NA 2700000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" Vesicles "Nucleoplasm, Cytosol" "CAB009966: AB_2225690, HPA047724: AB_2680132, HPA063595: AB_2685052, HPA064970: AB_2685394" "unprognostic (1.70e-2)" "unprognostic (5.42e-2)" "unprognostic (1.66e-2)" "unprognostic (1.45e-1)" "prognostic unfavorable (1.60e-4)" "unprognostic (1.13e-1)" "unprognostic (7.00e-2)" "unprognostic (8.79e-2)" "unprognostic (2.52e-1)" "unprognostic (3.27e-2)" "unprognostic (1.26e-1)" "unprognostic (1.94e-1)" "prognostic unfavorable (9.31e-9)" "unprognostic (2.88e-3)" "unprognostic (9.58e-2)" "unprognostic (1.17e-2)" "unprognostic (6.28e-3)" 190.5 59.9 45.0 59.8 56.0 10.6 153.0 38.6 44.8 312.1 28.0 95.3 19.2 268.8 59.6 65.7 199.8 155.9 156.7 47.3 92.9 68.7 20.3 166.0 45.5 114.7 81.5 253.7 28.9 10.1 43.3 89.0 79.6 112.1 25.0 1.3 50.7 213.5 21.3 84.8 79.1 119.3 74.3 54.4 71.2 40.4 52.1 73.3 83.7 14.1 16.7 138.7 198.0 66.6 0.6 0.0 44.5 0.1 141.1 49.6 1.0 193.0 126.0 21.6 4.5 0.0 0.1 5.3 20.9 208.9 0.2 0.1 2.4 3.5 9.1 0.6 0.0 13.3 0.1 0.0 39.6 0.1 0.3 75.8 0.0 72.9 0.1 1.1 9.7 145.0 8.3 0.3 0.0 0.2 86.9 16.1 19.1 0.0 0.4 71.3 1.7 1.7 5.0 0.0 4.9 25.3 0.1 0.3 85.9 41.9 0.4 14.4 34.1 0.0 86.2 0.5 0.3 1.0 0.9 102.8 0.4 0.2 117.9 0.0 0.0 0.0 0.3 0.0 0.2 1.5 0.2 0.0 0.0 1.4 0.9 0.5 0.0 0.1 0.0 7.6 0.0 0.3 45.0 56.0 38.6 44.8 47.3 92.9 114.7 81.5 79.6 74.3 52.1 66.6 23.6 0.0 2.5 32.3 11.8 34.5 5.7 1.3 1.8 0.8 2.0 14.6 26.4 1.5 1.4 7.3 0.0 2.0 22.7 0.0 0.0 0.9 3.1 3.3 103.0 18.0 0.0 1.3 0.1 0.0 3.3 263.2 8.6 2.9 2.5 33.3 30.4 0.6 3.6 0.0 0.3 0.0 0.0 1.8 42.0 18.0 151.6 3.2 85.4 17.8 1.0 0.2 1.0 6.0 0.3 0.4 0.0 508.9 9.7 16.9 0.0 2.2 2.2 0.8 39.5 23.6 173.4 4.0 4.6 1.5 27.4 3.4 4.8 28.7 0.0 2.4 AFG3L2 "SCA28, SPAX5" ENSG00000141385 "AFG3 like matrix AAA peptidase subunit 2" Q9Y4W6 18 12328944-12377227 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004479, HPA004480" Enhanced Supported Mitochondria NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 8: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" Mitochondria "HPA004479: AB_1078109, HPA004480: AB_1078108" "unprognostic (1.11e-1)" "unprognostic (7.49e-2)" "unprognostic (1.67e-1)" "prognostic unfavorable (8.68e-4)" "unprognostic (1.31e-1)" "unprognostic (5.06e-3)" "unprognostic (1.61e-1)" "unprognostic (2.33e-1)" "unprognostic (5.35e-2)" "unprognostic (1.54e-2)" "unprognostic (4.05e-2)" "unprognostic (3.00e-2)" "prognostic favorable (6.05e-14)" "unprognostic (5.90e-2)" "unprognostic (9.41e-2)" "unprognostic (5.74e-3)" "unprognostic (2.22e-1)" 26.1 25.9 16.4 21.9 17.0 32.4 29.2 18.2 19.0 24.1 30.8 60.8 79.9 22.1 17.5 41.5 23.8 18.3 88.0 17.0 18.7 62.7 51.0 21.8 23.7 17.7 16.6 24.1 41.1 76.0 18.6 23.5 18.8 24.6 54.1 20.3 30.8 24.4 145.4 29.8 58.7 25.4 15.8 18.5 39.1 18.5 19.0 24.3 39.2 155.8 31.0 30.9 19.6 17.6 56.5 56.6 39.7 44.8 45.2 48.6 52.7 61.9 61.1 86.6 63.1 88.1 34.1 161.3 66.3 56.6 76.8 55.6 101.4 71.3 70.3 38.1 43.5 48.5 59.3 83.5 61.1 185.0 69.8 54.3 76.3 82.1 107.7 47.8 64.0 57.0 111.3 92.8 43.6 89.0 66.7 58.5 55.3 277.4 41.9 74.0 125.1 135.2 74.9 123.6 73.7 51.3 97.0 103.8 90.0 50.5 47.8 84.5 49.0 102.4 88.6 98.7 81.7 64.7 80.7 104.1 56.2 71.4 48.0 3.8 16.5 12.4 11.6 17.6 13.9 14.0 13.8 17.9 21.8 10.3 17.2 20.2 1.1 28.4 16.2 11.5 9.5 13.4 16.4 17.0 18.2 19.0 17.0 18.7 17.7 16.6 18.8 15.8 19.0 17.6 24.3 41.7 49.2 23.2 36.6 22.2 45.3 21.5 42.7 50.2 36.5 36.2 74.9 50.1 28.1 35.0 50.1 58.5 29.1 85.2 72.4 39.5 5.5 37.8 52.3 27.7 39.1 61.0 21.1 37.4 37.9 31.2 53.5 46.1 14.5 41.3 21.8 85.6 37.0 30.3 26.8 82.6 18.3 32.6 14.4 5.5 32.9 34.2 23.2 12.2 27.6 26.9 40.2 14.1 17.7 47.8 43.1 30.1 38.8 43.1 88.7 100.0 22.1 58.3 26.3 53.6 26.9 50.9 65.0 75.8 31.3 92.8 28.4 60.8 94.9 38.2 AGBL1 "CCP4, FLJ32310" ENSG00000273540 "ATP/GTP binding protein like 1" Q96MI9 15 86079871-87049169 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Corneal dystrophy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 10 "skeletal muscle: 7.8;tongue: 23.2" "Cell type enhanced" "Detected in some" "Alveolar cells type 2: 16.7;Astrocytes: 28.7;Excitatory neurons: 15.6;Inhibitory neurons: 25.6;Oligodendrocyte precursor cells: 47.3" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 68: Oligodendrocytes - Mixed function" "unprognostic (3.70e-2)" "unprognostic (4.46e-2)" "unprognostic (1.06e-1)" 0.0 0.0 0.6 0.0 1.4 0.0 0.0 0.0 0.7 0.0 0.2 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 1.0 0.3 0.0 0.0 0.7 0.0 1.0 0.8 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.1 0.7 0.0 7.8 0.0 0.0 0.0 0.9 0.0 0.0 0.1 0.4 0.0 0.0 23.2 0.0 0.0 0.0 0.4 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 1.4 0.0 0.7 1.0 0.3 1.0 0.8 0.3 0.9 0.4 0.4 0.0 3.2 16.7 28.7 0.0 0.0 0.1 0.0 0.0 1.7 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.1 0.0 0.0 15.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 25.6 0.0 0.0 0.0 0.0 2.3 0.0 0.1 0.0 1.9 0.0 0.0 0.0 47.3 6.9 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 5.2 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.1 AGBL2 "CCP2, FLJ23598" ENSG00000165923 "ATP/GTP binding protein like 2" Q5U5Z8 11 47659591-47715389 "Enzymes, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "fallopian tube: 7.7;testis: 12.5" "Cell type enhanced" "Detected in many" "Early spermatids: 37.5;Endometrial ciliated cells: 25.7;Respiratory ciliated cells: 77.2;Spermatocytes: 19.3" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CAPAN-2: 2.3;T-47d: 1.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA007718 Uncertain NA NA "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 49: Ciliated cells - Cilium organization" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 49: Ciliated cells - Cilium organization" "HPA007718: AB_1078110" "unprognostic (3.44e-5)" "unprognostic (1.16e-1)" "unprognostic (5.84e-2)" "unprognostic (5.33e-4)" "unprognostic (1.13e-1)" "unprognostic (3.00e-1)" "unprognostic (2.05e-1)" "unprognostic (1.38e-2)" "unprognostic (9.83e-3)" "unprognostic (4.11e-2)" "unprognostic (5.56e-2)" "unprognostic (1.79e-1)" "unprognostic (8.24e-6)" "unprognostic (1.01e-2)" "unprognostic (1.28e-1)" "unprognostic (9.62e-2)" "unprognostic (1.17e-3)" 0.3 1.3 0.3 0.4 0.2 0.2 0.5 0.7 0.3 1.4 2.6 0.8 0.3 0.6 1.1 0.4 7.7 0.2 0.2 0.3 0.4 1.6 3.0 1.6 0.5 1.2 1.8 1.3 0.8 0.3 1.7 0.2 0.8 1.2 0.2 0.3 0.5 0.4 0.0 0.4 1.2 0.1 1.0 0.9 0.6 12.5 0.2 0.7 1.5 0.0 0.4 1.1 0.6 0.4 0.4 0.0 0.0 0.0 0.1 0.6 0.0 0.1 0.3 0.2 0.6 0.2 2.3 0.0 0.1 0.1 0.2 0.6 0.0 0.0 0.3 0.7 0.1 0.1 1.1 0.8 0.3 0.0 0.3 0.6 0.2 0.3 0.2 0.2 0.0 0.8 0.1 0.5 0.3 0.9 0.5 0.2 0.0 0.1 0.0 0.6 0.0 0.2 0.3 1.0 0.8 0.1 0.2 0.0 0.2 0.0 1.3 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.3 0.0 0.3 0.2 0.3 0.3 0.0 0.5 0.4 0.4 0.1 0.3 0.0 0.3 0.5 0.1 0.3 0.2 0.7 0.3 0.3 0.4 1.2 1.8 0.8 1.0 0.2 0.4 0.1 0.0 2.7 2.6 1.3 0.1 1.3 2.6 2.2 0.1 0.9 0.6 0.6 0.0 6.5 7.3 0.0 0.4 0.5 0.7 0.0 0.4 37.5 25.7 1.3 0.1 1.2 0.8 0.6 0.0 0.3 1.2 1.5 0.9 0.0 0.8 0.4 0.8 0.1 0.0 0.6 0.5 2.0 0.6 0.0 8.2 0.3 0.3 0.0 1.0 1.0 0.7 0.0 1.0 0.5 0.3 0.6 1.5 0.4 0.4 2.4 0.2 77.2 0.5 0.0 0.3 1.1 19.3 1.8 0.6 0.0 0.4 1.3 1.3 0.9 0.5 AGBL3 "CCP3, MGC32955" ENSG00000146856 "ATP/GTP binding protein like 3" Q8NEM8 7 134986508-135147963 "Enzymes, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in many" "epididymis: 7.9" "Cell type enhanced" "Detected in many" "Early spermatids: 70.5;Excitatory neurons: 40.7;Inhibitory neurons: 34.2;Oligodendrocytes: 37.3" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "HEK 293: 5.5" "Low region specificity" "Detected in all" "HPA020397, HPA024150" Uncertain Approved Cytosol NA No "Cluster 22: NK-cells - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 23: Spermatids - Flagellum & Golgi organization" Cytosol "HPA020397: AB_2242453, HPA024150: AB_1844639" "unprognostic (8.84e-2)" "unprognostic (1.49e-2)" "unprognostic (4.72e-2)" "unprognostic (2.18e-1)" "unprognostic (1.47e-1)" "unprognostic (3.39e-3)" "unprognostic (3.32e-3)" "unprognostic (4.18e-2)" "unprognostic (7.15e-4)" "unprognostic (5.00e-3)" "unprognostic (6.10e-4)" "unprognostic (3.16e-2)" "prognostic unfavorable (4.02e-4)" "unprognostic (2.18e-2)" "unprognostic (2.14e-1)" "unprognostic (8.13e-2)" "unprognostic (1.11e-3)" 1.0 0.9 1.0 2.3 1.3 2.2 2.3 2.0 3.0 0.8 1.2 1.2 0.8 2.9 7.9 0.1 1.8 0.7 0.8 1.0 1.9 1.7 0.6 1.8 2.3 1.3 1.2 3.5 2.3 0.4 0.3 0.9 1.1 1.9 1.5 1.3 2.5 2.1 2.4 2.5 2.0 1.6 1.3 3.8 2.5 5.1 1.7 0.9 2.8 0.8 0.9 0.3 0.2 1.8 1.7 0.9 2.2 0.5 0.6 0.8 1.3 0.4 0.0 0.3 0.5 3.0 1.9 2.7 0.8 0.0 0.9 1.8 0.8 0.3 0.0 2.2 5.5 2.3 4.0 3.0 0.0 1.0 0.0 0.1 0.0 1.3 0.0 0.0 0.9 3.0 1.7 1.5 0.3 1.5 0.6 0.9 1.9 0.2 0.2 1.6 0.1 0.8 1.5 0.3 1.3 1.4 0.3 0.0 0.2 0.0 1.2 2.3 0.0 0.2 0.5 0.3 1.0 3.3 1.1 1.3 1.1 2.8 2.7 0.0 0.1 0.1 0.8 0.0 0.7 0.8 0.4 0.9 0.2 0.7 0.7 1.7 0.2 0.9 0.0 0.6 0.6 0.6 1.0 1.3 2.0 3.0 1.0 1.9 1.3 1.2 1.1 1.3 1.7 1.8 6.7 3.2 0.6 18.3 3.5 1.3 0.9 1.2 2.8 5.1 2.2 2.2 2.1 4.3 2.0 9.2 2.1 0.3 0.9 0.6 7.9 4.6 70.5 6.6 1.8 4.8 3.0 3.0 40.7 2.9 0.4 2.8 4.6 2.6 1.3 3.2 5.0 1.9 0.5 3.3 34.2 0.4 0.0 1.3 0.7 11.8 3.4 0.8 5.4 22.5 6.9 2.8 1.0 16.6 37.3 1.7 0.1 2.2 6.1 1.3 0.4 7.6 6.4 3.3 0.0 2.0 4.1 21.4 6.3 1.2 0.3 0.1 2.0 2.4 0.5 1.0 AGBL4 "CCP6, FLJ14442" ENSG00000186094 "ATP/GTP binding protein like 4" Q5VU57 1 48532854-50023954 "Enzymes, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 5.4;retina: 5.9" "Group enriched" "Detected in some" 5 "Excitatory neurons: 1232.8;Inhibitory neurons: 630.3" "Not detected" "Not detected" "Region enhanced" "Detected in many" "cerebral cortex: 5.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "NTERA-2: 1.1;SCLC-21H: 1.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA037994 Approved NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 58: Brain - Synaptic function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA037994: AB_10673036" "unprognostic (3.06e-2)" "unprognostic (2.76e-1)" "unprognostic (2.58e-2)" "unprognostic (3.31e-4)" "unprognostic (3.42e-4)" "unprognostic (1.72e-1)" "unprognostic (3.86e-3)" "unprognostic (2.31e-2)" "unprognostic (1.50e-1)" "unprognostic (1.14e-1)" "unprognostic (5.85e-3)" "unprognostic (3.91e-2)" "unprognostic (1.51e-4)" "unprognostic (5.95e-2)" "unprognostic (1.11e-1)" "unprognostic (1.18e-2)" "unprognostic (2.85e-1)" 0.4 1.5 2.0 0.1 2.4 0.2 0.4 0.0 5.4 0.2 2.3 0.1 0.0 0.2 0.8 0.1 2.8 0.1 1.4 2.0 0.0 3.9 1.6 0.4 0.1 0.0 0.5 0.3 0.8 2.4 2.4 0.9 0.2 0.1 0.1 5.9 0.1 0.3 0.1 0.3 0.1 0.0 0.0 0.3 0.2 2.4 0.1 0.4 1.1 0.1 0.1 0.0 0.1 0.8 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 1.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 1.5 0.6 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.1 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 2.0 2.4 0.0 5.4 2.0 0.0 0.0 0.5 0.2 0.0 0.1 0.8 0.2 0.0 0.0 166.2 0.0 0.3 1.0 0.3 0.0 4.0 0.4 1.1 2.2 0.0 0.9 3.7 85.5 0.2 0.0 0.4 1.9 0.1 12.6 10.7 0.1 0.4 6.0 0.0 1232.8 0.2 0.1 0.5 0.0 0.2 0.0 0.2 0.4 0.1 0.1 5.0 630.3 0.5 2.0 0.0 0.0 9.1 0.3 0.0 0.0 40.3 0.0 2.4 0.0 142.2 19.2 0.0 0.1 0.7 0.0 0.3 0.0 4.4 10.5 22.6 0.0 0.7 0.3 19.9 10.4 0.0 0.0 0.1 0.0 0.4 0.1 0.2 AGBL5 "CCP5, FLJ21839" ENSG00000084693 "ATP/GTP binding protein like 5" Q8NDL9 2 27042364-27070622 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in all" 4 "parathyroid gland: 49.9;testis: 192.9" "Group enriched" "Detected in many" 6 "Early spermatids: 302.7;Late spermatids: 338.0;Spermatocytes: 156.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030981 Uncertain Supported "Microtubules,Cytokinetic bridge,Cytosol" Yes No "Cluster 34: Basophils - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" "Cytokinetic bridge" "Microtubules, Cytosol" "HPA030981: AB_10611673" "unprognostic (1.29e-2)" "unprognostic (8.70e-2)" "unprognostic (2.26e-1)" "unprognostic (3.13e-3)" "unprognostic (1.95e-1)" "unprognostic (1.07e-1)" "prognostic unfavorable (6.87e-5)" "unprognostic (1.86e-1)" "unprognostic (4.34e-1)" "unprognostic (6.20e-2)" "unprognostic (1.28e-1)" "unprognostic (1.20e-1)" "unprognostic (3.41e-2)" "unprognostic (5.56e-2)" "unprognostic (2.05e-1)" "unprognostic (1.69e-2)" "unprognostic (4.50e-2)" 8.8 16.7 8.4 8.0 7.4 13.6 12.4 7.8 8.2 14.4 9.5 16.2 8.8 14.0 26.0 18.3 20.8 14.3 12.7 7.3 11.3 22.5 7.2 11.2 10.7 8.3 7.8 14.4 15.0 49.9 12.5 11.2 8.9 15.2 11.5 16.3 21.2 16.5 7.1 20.5 9.9 14.6 6.1 8.5 11.8 192.9 9.1 15.6 28.5 6.5 8.6 14.9 7.3 7.5 55.0 34.7 55.4 37.2 11.6 23.0 62.9 10.9 23.5 30.9 31.9 30.2 40.5 30.3 34.0 18.9 43.4 24.6 44.8 49.4 33.9 25.9 66.8 44.5 42.0 65.7 23.6 21.6 14.4 24.4 36.7 27.1 22.0 46.9 32.8 43.5 38.9 23.8 30.3 21.5 63.2 32.3 39.4 39.4 23.7 64.5 62.9 48.0 31.9 13.6 37.1 53.6 21.5 16.7 35.0 53.9 24.9 16.3 16.4 28.6 39.2 13.8 23.9 47.7 27.2 62.4 31.8 24.4 26.1 8.8 1.8 4.5 3.3 1.1 2.5 4.6 4.1 4.6 4.1 2.3 3.6 2.2 1.1 8.5 0.7 2.3 2.8 3.8 8.4 7.4 7.8 8.2 7.3 11.3 8.3 7.8 8.9 6.1 9.1 7.5 3.6 0.0 10.1 5.2 6.3 3.3 8.3 7.2 13.6 5.7 8.6 6.7 6.7 10.0 6.8 9.2 0.0 14.7 1.8 5.9 19.6 8.3 302.7 13.0 3.9 4.9 2.4 11.6 7.9 6.0 7.9 6.4 5.6 5.8 1.3 14.1 6.4 4.1 5.2 0.0 9.1 8.4 6.1 3.1 3.5 338.0 10.5 8.0 7.2 6.5 4.9 6.8 0.0 10.1 10.1 5.0 7.6 11.3 17.1 6.0 6.3 25.0 10.7 10.0 0.0 4.2 7.0 156.8 41.2 16.3 2.7 8.3 5.0 9.4 8.6 10.5 AGTPBP1 "CCP1, KIAA1035, Nna1" ENSG00000135049 "ATP/GTP binding protein 1" Q9UPW5 9 85546539-85742029 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 60.1;brain: 73.4;retina: 46.5" "Cell type enhanced" "Detected in many" "Excitatory neurons: 176.7;Inhibitory neurons: 163.0;Oligodendrocytes: 463.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA057208, HPA071094" Approved Approved Nucleoli,Vesicles NA NA "Cluster 38: Basophils - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Nucleoli, Vesicles" "HPA057208: AB_2683370, HPA071094: " "unprognostic (2.15e-1)" "unprognostic (3.78e-2)" "unprognostic (4.93e-3)" "unprognostic (6.12e-2)" "unprognostic (1.42e-1)" "unprognostic (8.95e-3)" "unprognostic (1.86e-2)" "unprognostic (1.65e-1)" "unprognostic (1.71e-1)" "unprognostic (8.26e-3)" "unprognostic (5.69e-3)" "unprognostic (6.31e-2)" "unprognostic (3.07e-2)" "unprognostic (1.11e-1)" "unprognostic (1.39e-1)" "unprognostic (9.60e-3)" "unprognostic (1.25e-1)" 8.4 5.5 31.1 9.5 44.3 60.1 6.2 23.2 36.3 4.7 0.0 5.1 3.7 4.9 3.9 5.3 4.6 5.3 12.2 20.1 30.3 6.9 4.6 14.4 9.4 30.5 28.6 3.6 6.7 7.5 5.3 6.1 31.5 4.7 5.8 46.5 4.1 3.0 16.5 6.2 5.1 6.5 32.0 14.8 5.5 14.1 34.3 12.4 5.8 20.5 8.4 5.7 4.3 73.4 5.1 9.6 27.9 11.1 5.6 6.0 10.6 7.4 6.4 7.4 8.4 5.2 8.6 31.3 6.2 7.7 13.2 2.9 13.0 9.4 6.9 33.6 11.8 5.3 11.5 9.3 11.8 24.5 6.2 5.8 10.8 7.0 23.5 4.8 11.9 15.9 6.7 24.5 3.3 8.0 19.3 14.5 19.3 18.1 6.8 17.3 10.2 9.8 12.8 5.4 33.5 23.7 8.4 9.1 15.4 26.1 3.5 7.8 12.0 4.8 8.5 30.4 8.9 16.7 14.8 14.3 10.1 23.5 9.8 37.4 14.4 12.7 9.0 8.4 8.8 2.3 4.4 7.0 15.6 1.7 3.7 7.0 21.2 6.8 6.7 2.5 5.1 9.6 31.1 44.3 23.2 36.3 20.1 30.3 30.5 28.6 31.5 32.0 34.3 73.4 22.3 64.1 12.8 46.0 14.3 7.9 2.6 2.9 8.0 38.0 4.7 4.8 48.3 0.0 13.8 3.7 102.2 4.1 41.8 4.3 7.9 5.7 52.5 29.3 8.6 12.0 7.7 16.8 176.7 4.0 4.3 6.9 9.2 22.0 27.1 9.2 8.2 3.7 8.1 35.3 163.0 5.6 6.1 35.4 24.1 53.9 1.8 42.8 3.6 61.8 46.6 16.7 47.4 82.9 463.5 5.1 1.2 2.6 26.2 3.8 3.2 9.8 14.7 59.1 13.1 9.3 10.4 46.6 29.2 9.2 10.7 2.9 26.3 6.4 4.7 2.3 AMZ1 KIAA1950 ENSG00000174945 "Archaelysin family metallopeptidase 1" Q400G9 7 2679522-2775500 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 8 "brain: 7.5" "Cell type enriched" "Detected in some" 5 "Oligodendrocyte precursor cells: 104.5" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in single" "memory B-cell: 1.2" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "BEWO: 7.0;MCF7: 7.5;SK-BR-3: 5.2;T-47d: 27.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA020233 Uncertain NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 65: Brain - Ion transport" "Cluster 6: T47d - Mammary gland" "Cluster 68: Oligodendrocytes - Mixed function" "HPA020233: AB_1844818" "unprognostic (9.08e-3)" "unprognostic (1.66e-1)" "unprognostic (3.23e-3)" "unprognostic (1.81e-1)" "unprognostic (5.72e-2)" "unprognostic (7.79e-2)" "unprognostic (2.02e-2)" "unprognostic (3.42e-1)" "unprognostic (1.98e-1)" "unprognostic (7.16e-3)" "unprognostic (1.08e-1)" "unprognostic (1.21e-1)" "unprognostic (3.64e-9)" "unprognostic (1.60e-3)" "unprognostic (1.60e-1)" "unprognostic (1.44e-1)" "unprognostic (1.13e-1)" 0.0 0.0 7.4 0.2 7.5 0.4 0.1 3.4 5.1 0.9 0.0 0.1 0.1 0.8 0.0 0.0 0.3 0.1 0.1 3.6 1.9 0.0 0.8 0.5 0.2 3.6 3.7 0.2 0.1 0.0 0.6 0.8 2.1 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.7 0.6 0.4 0.0 0.6 6.1 0.0 0.0 0.0 0.3 0.1 0.3 1.7 0.0 0.0 0.0 0.0 0.0 0.0 7.0 2.3 3.4 1.6 2.2 0.0 1.0 0.6 0.2 2.2 0.2 0.0 0.0 0.0 1.6 0.4 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 1.5 0.0 7.5 0.0 0.7 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.1 5.2 0.0 0.1 27.7 0.0 0.0 0.1 0.1 0.1 0.1 1.0 0.2 0.0 0.6 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 7.4 7.5 3.4 5.1 3.6 1.9 3.6 3.7 2.1 0.6 6.1 1.7 0.1 0.0 0.5 14.4 0.9 0.0 0.1 0.0 0.0 0.8 0.3 0.3 3.3 0.0 0.0 0.0 4.2 0.3 1.6 0.0 0.0 0.0 18.8 0.5 1.6 0.4 0.0 0.0 6.1 0.0 9.8 0.3 0.0 0.3 0.0 0.0 0.0 0.0 1.8 0.0 10.6 0.2 0.0 0.0 1.9 9.9 0.0 1.7 1.8 5.6 0.0 0.0 0.0 104.5 20.7 0.4 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.7 0.0 0.2 0.4 0.0 0.3 0.0 0.1 0.1 0.8 0.0 0.0 0.1 AMZ2 ENSG00000196704 "Archaelysin family metallopeptidase 2" Q86W34 17 68205481-68257712 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 477.3;Early spermatids: 736.8;Late spermatids: 1665.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023299, HPA052406" Enhanced Supported "Nucleoplasm,Nuclear bodies,Cytosol" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 43: Testis - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "Nuclear bodies, Cytosol" "HPA023299: AB_2226909, HPA052406: AB_2681818" "unprognostic (3.04e-1)" "unprognostic (3.68e-2)" "unprognostic (3.93e-2)" "unprognostic (3.27e-3)" "unprognostic (3.32e-1)" "unprognostic (1.79e-2)" "prognostic unfavorable (1.32e-5)" "unprognostic (2.43e-1)" "unprognostic (3.92e-2)" "unprognostic (2.83e-3)" "unprognostic (3.59e-3)" "unprognostic (3.37e-1)" "prognostic unfavorable (3.14e-4)" "unprognostic (2.37e-1)" "unprognostic (2.95e-1)" "unprognostic (3.28e-1)" "unprognostic (7.62e-2)" 52.3 51.8 54.5 32.6 66.4 36.4 45.0 57.1 87.2 41.2 50.0 57.8 26.2 44.5 53.4 38.4 52.5 37.9 77.0 59.5 56.6 59.2 38.1 32.9 54.0 58.8 56.7 48.7 45.3 64.4 59.1 29.5 58.0 41.6 32.9 78.5 40.0 51.2 95.6 43.1 36.9 41.7 55.3 43.3 39.7 194.4 60.0 53.2 53.3 86.8 51.7 48.5 36.5 61.4 94.6 98.9 87.5 72.9 65.6 113.4 140.0 71.0 88.3 116.1 93.7 42.3 60.4 142.6 74.9 104.8 107.0 46.0 68.6 198.5 154.0 50.2 67.7 52.8 38.6 83.1 124.9 49.8 86.9 96.9 213.9 107.5 206.2 113.0 118.9 121.7 54.6 86.5 150.9 67.3 110.2 45.4 43.5 51.1 98.5 41.3 238.9 106.7 71.2 50.1 85.7 67.2 64.8 125.5 130.9 184.6 100.7 33.5 65.2 143.8 72.0 55.8 74.8 121.9 121.9 255.7 105.1 69.0 79.1 76.6 25.2 35.3 34.8 30.3 46.2 30.7 43.2 46.0 30.3 41.3 37.8 40.4 45.1 63.7 40.9 28.1 58.3 36.9 54.5 66.4 57.1 87.2 59.5 56.6 58.8 56.7 58.0 55.3 60.0 61.4 18.5 12.8 15.6 477.3 38.7 18.6 31.6 58.4 30.1 13.8 29.7 34.3 81.4 21.5 32.8 23.9 8.4 64.0 58.0 9.4 109.5 28.8 736.8 28.4 17.2 24.4 21.1 21.0 36.4 26.0 66.9 28.2 14.8 18.5 34.1 28.9 21.4 15.5 41.8 18.5 30.0 16.7 40.7 26.1 71.0 1665.0 36.1 39.0 56.9 27.2 46.4 65.7 69.0 56.8 47.7 25.4 10.8 32.7 46.2 17.7 15.2 69.0 61.8 12.8 19.7 26.5 26.8 274.4 59.4 26.4 22.6 34.2 49.3 26.1 15.1 24.5 ANPEP "CD13, gp150, LAP1, p150, PEPN" ENSG00000166825 "Alanyl aminopeptidase, membrane" P15144 15 89784895-89815401 "CD markers, Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Angiogenesis, Differentiation, Host-virus interaction" "Aminopeptidase, Developmental protein, Host cell receptor for virus entry, Hydrolase, Metalloprotease, Protease, Receptor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "intestine: 2384.1;pancreas: 675.0" "Cell type enriched" "Detected in many" 14 "Proximal enterocytes: 6315.2" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in all" 5 "cerebral cortex: 9.2;thalamus: 17.4" "Immune cell enriched" "Detected in many" 4 "neutrophil: 227.1" "Lineage enriched" "Detected in many" 4 "granulocytes: 227.1" "Cell line enhanced" "Detected in many" "ASC diff: 613.7;ASC TERT1: 764.2;BJ: 738.4;BJ hTERT+: 1135.6;fHDF/TERT166: 703.8;HMC-1: 660.3;HSkMC: 670.0;HUVEC TERT2: 874.8;TIME: 815.1;U-2197: 891.4" "Low region specificity" "Detected in all" "Region enriched" "Detected in many" 5 "spinal cord: 14.8" "CAB002417, HPA004625" Enhanced Supported "Plasma membrane" NA NA 1200000000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 56: Intestine - Transmembrane transport" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 45: Enterocytes - Digestion" "Plasma membrane" "CAB002417: AB_563491, HPA004625: AB_2667199" "unprognostic (6.31e-2)" "unprognostic (7.94e-3)" "unprognostic (6.91e-2)" "unprognostic (2.16e-1)" "unprognostic (2.50e-1)" "unprognostic (1.13e-1)" "unprognostic (2.23e-2)" "unprognostic (1.89e-1)" "unprognostic (2.50e-1)" "unprognostic (7.73e-2)" "unprognostic (5.28e-3)" "unprognostic (3.96e-1)" "unprognostic (4.04e-3)" "unprognostic (3.20e-2)" "unprognostic (2.01e-2)" "unprognostic (4.61e-3)" "unprognostic (1.99e-2)" 55.4 7.0 1.6 36.6 1.6 103.4 55.9 1.3 9.2 41.4 3.4 266.8 2384.1 3.6 1.7 4.8 8.0 120.3 6.9 1.3 1.5 249.7 271.8 34.3 12.8 1.5 2.1 1.9 675.0 0.8 1.9 33.1 2.5 94.0 59.9 0.0 42.1 5.5 2.5 32.5 1970.6 29.7 1.3 25.9 8.0 2.0 17.4 7.1 8.2 3.8 4.7 16.8 15.0 1.2 0.1 45.6 0.0 0.5 613.7 764.2 6.2 738.4 1135.6 95.3 81.6 5.8 0.4 0.2 8.4 703.8 0.0 0.6 5.6 0.2 38.6 0.1 0.1 137.3 4.6 122.8 352.0 11.4 660.3 670.0 1.4 302.3 0.3 4.4 874.8 0.0 3.8 0.8 37.8 0.1 0.6 355.4 1.9 0.0 49.9 0.3 0.1 9.5 449.2 0.0 1.2 7.2 0.1 1.3 0.1 1.8 0.5 72.1 815.1 385.3 0.6 891.4 0.1 0.4 0.1 0.1 0.9 0.9 20.5 22.2 56.3 41.1 0.1 27.4 0.0 0.2 0.0 0.0 26.2 0.2 0.0 0.0 227.1 0.0 49.7 0.7 0.0 25.7 1.6 1.6 1.3 9.2 1.3 1.5 1.5 2.1 2.5 1.3 17.4 1.2 2.4 0.0 3.0 0.0 5.2 9.9 2.8 1.4 0.6 0.0 35.7 12.8 1.2 391.7 19.7 20.2 0.0 13.0 0.7 429.8 43.0 15.4 0.2 0.5 10.1 8.4 3.0 6.6 0.3 386.2 16.3 31.0 0.0 0.4 24.1 0.3 79.2 192.4 37.5 0.0 0.3 199.6 2.0 54.1 63.2 0.2 2.8 71.9 3.6 0.0 38.3 0.0 0.0 0.0 0.1 75.5 316.9 1.5 2.1 20.9 6315.2 435.0 3.3 0.0 26.3 0.8 8.1 0.3 0.5 0.2 5.8 6.4 3.7 187.8 290.9 1.4 AOPEP "AP-O, APO, C90RF3, C9orf3, FLJ14675" ENSG00000148120 "Aminopeptidase O (putative)" Q8N6M6 9 94726604-95087159 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in some" 4 "Cardiomyocytes: 148.2;Cytotrophoblasts: 65.9;Extravillous trophoblasts: 43.7;Syncytiotrophoblasts: 88.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "HeLa: 30.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004633, HPA072729" Approved Approved "Cell Junctions" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 20: HeLa - Mitochondria" "Cluster 24: Non-specific - Transcription regulation" "Cell Junctions" "HPA004633: AB_1078362, HPA072729: AB_2686553" "unprognostic (4.25e-2)" "unprognostic (1.07e-3)" "unprognostic (6.29e-2)" "unprognostic (1.71e-1)" "unprognostic (1.12e-1)" "unprognostic (2.75e-2)" "unprognostic (9.59e-2)" "unprognostic (4.24e-2)" "unprognostic (2.99e-2)" "unprognostic (1.34e-1)" "unprognostic (2.60e-2)" "unprognostic (2.80e-1)" "prognostic favorable (6.33e-5)" "unprognostic (2.31e-1)" "unprognostic (2.56e-1)" "unprognostic (3.29e-2)" "unprognostic (3.37e-2)" 5.6 6.6 11.8 4.9 20.4 2.2 7.0 16.9 16.3 8.1 23.8 6.9 4.3 18.5 8.3 16.9 10.3 12.1 29.4 15.9 15.5 7.2 7.6 10.4 2.2 23.0 15.7 8.1 11.2 16.3 5.7 24.3 20.7 14.3 5.8 4.7 12.2 15.2 30.5 38.6 5.0 15.8 11.1 5.0 5.7 6.0 15.4 2.6 11.2 15.3 5.6 7.7 6.8 40.5 6.8 27.6 3.3 5.3 3.4 3.8 12.4 6.4 3.0 6.3 4.1 6.3 8.7 2.1 5.3 9.8 8.7 24.8 5.7 6.1 3.4 13.2 4.9 2.0 30.1 5.8 6.1 1.8 1.4 4.4 23.7 5.5 4.1 17.7 3.5 3.3 3.4 3.0 11.4 10.1 2.8 2.3 4.4 7.8 10.7 4.2 9.4 2.7 11.0 6.4 6.6 9.7 11.2 9.4 2.5 8.5 10.8 1.5 2.7 2.9 2.8 10.8 3.4 2.5 3.6 1.0 9.8 1.7 4.8 0.0 1.4 0.9 1.4 1.0 0.8 0.9 1.1 1.2 2.2 2.2 0.8 1.0 0.5 1.4 0.7 2.1 0.8 0.7 11.8 20.4 16.9 16.3 15.9 15.5 23.0 15.7 20.7 11.1 15.4 40.5 20.2 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 148.2 0.0 0.0 0.0 0.0 65.9 1.7 0.0 0.0 0.0 0.0 0.0 0.0 7.4 0.0 0.0 0.0 0.0 43.7 13.8 0.0 0.0 0.0 0.0 0.0 0.0 9.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.1 0.0 0.0 0.0 0.0 88.2 0.2 0.0 0.0 0.0 APEH "D3F15S2, D3S48E, DNF15S2" ENSG00000164062 "Acylaminoacyl-peptide hydrolase" P13798 3 49674014-49683971 "Enzymes, Plasma proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029700, HPA029701, HPA029702, HPA029703" Enhanced Enhanced Cytosol No No 2300000 "Cluster 27: Non-specific - Gene expression" "Cluster 8: Non-specific - Mitochondria" "Cluster 3: HMC-1 - Innate immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "HPA029700: AB_10599278, HPA029701: AB_10600333, HPA029702: AB_10602411, HPA029703: AB_10601348" "unprognostic (4.93e-2)" "unprognostic (5.42e-2)" "unprognostic (6.04e-3)" "unprognostic (2.71e-1)" "unprognostic (9.32e-2)" "unprognostic (8.20e-2)" "unprognostic (3.65e-2)" "unprognostic (2.48e-1)" "unprognostic (5.89e-2)" "unprognostic (8.03e-2)" "unprognostic (3.21e-1)" "unprognostic (4.30e-2)" "prognostic favorable (3.32e-10)" "unprognostic (2.11e-2)" "unprognostic (1.12e-1)" "unprognostic (4.34e-2)" "unprognostic (7.67e-2)" 21.7 43.6 18.0 30.7 18.0 42.3 26.8 17.9 22.8 24.8 27.7 48.5 48.6 19.7 24.7 40.2 33.7 22.3 40.6 17.7 19.9 65.8 63.3 26.8 35.2 19.2 21.3 24.6 34.8 63.0 38.3 31.9 24.3 31.0 51.7 12.9 34.0 29.5 103.8 32.8 35.1 28.1 16.8 27.2 35.5 18.7 20.0 37.3 48.6 103.9 43.4 35.0 21.2 16.7 101.2 79.2 84.2 110.8 71.3 48.3 113.6 64.2 79.3 87.4 91.2 130.1 101.7 127.1 70.0 71.7 78.9 89.8 95.1 143.4 64.2 61.9 41.0 138.8 123.4 105.1 72.0 145.5 204.7 55.0 106.5 49.2 101.4 85.5 78.7 86.4 86.6 59.8 86.0 90.8 105.3 76.6 50.4 140.5 75.3 38.4 72.8 165.1 169.9 226.7 40.4 71.2 72.4 166.7 78.9 61.0 112.1 77.2 36.1 53.8 93.0 83.6 86.8 69.8 54.5 77.7 91.7 104.1 78.7 57.9 43.0 52.8 44.8 47.6 34.8 33.3 36.3 41.9 43.6 27.6 37.9 37.4 13.6 39.0 47.6 35.1 50.4 51.9 18.0 18.0 17.9 22.8 17.7 19.9 19.2 21.3 24.3 16.8 20.0 16.7 5.4 41.7 25.3 7.5 20.1 8.7 23.3 50.2 11.4 6.8 20.8 15.9 46.8 30.0 39.4 27.6 12.5 83.7 16.5 83.2 43.0 44.4 6.4 16.6 13.8 9.0 26.5 43.8 4.8 34.7 64.8 16.4 41.8 20.5 23.5 20.0 13.2 74.7 51.1 8.4 4.7 47.1 63.1 35.9 11.9 10.9 15.2 23.2 21.4 2.8 26.8 30.4 27.8 3.0 2.0 39.0 35.8 13.5 39.4 18.0 85.4 80.7 19.4 11.1 13.1 10.6 25.2 33.2 28.5 30.6 9.2 62.1 23.9 28.5 74.0 23.7 ATG4A "APG4A, AUTL2" ENSG00000101844 "Autophagy related 4A cysteine peptidase" Q8WYN0 X 108091668-108154671 "Enzymes, Predicted intracellular proteins" "Autophagy, Protein transport, Transport, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HUVEC TERT2: 84.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036374, HPA064759" Uncertain Approved "Actin filaments,Microtubules" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 6: Erythroid cells - Oxygen transport" Microtubules "Actin filaments" "HPA036374: AB_10672354, HPA064759: AB_2685346" "prognostic unfavorable (1.36e-5)" "unprognostic (1.41e-2)" "unprognostic (3.65e-1)" "unprognostic (2.52e-1)" "unprognostic (1.28e-1)" "unprognostic (1.79e-1)" "unprognostic (1.18e-1)" "unprognostic (2.83e-3)" "unprognostic (2.23e-1)" "unprognostic (3.14e-1)" "unprognostic (2.62e-2)" "unprognostic (4.09e-1)" "unprognostic (1.03e-3)" "unprognostic (7.53e-2)" "unprognostic (2.98e-1)" "unprognostic (5.02e-3)" "unprognostic (1.20e-2)" 8.1 8.5 4.9 7.8 5.2 9.1 7.7 5.2 6.1 7.6 10.4 12.1 12.8 4.7 11.6 8.9 5.6 7.7 11.8 4.7 5.2 14.1 18.1 8.9 8.2 5.3 5.0 2.8 17.2 12.4 6.1 8.0 5.4 5.9 13.1 5.7 13.0 7.1 18.5 5.8 11.4 7.7 5.0 7.7 11.2 2.4 5.7 11.2 11.4 18.6 11.1 8.9 5.1 5.4 13.0 6.5 4.1 7.8 38.2 13.2 5.1 17.5 11.2 9.1 10.6 5.3 6.9 14.0 15.7 14.0 14.5 6.0 11.9 13.0 13.5 24.1 12.9 6.0 10.3 3.7 8.4 13.0 18.8 13.4 13.9 11.1 4.8 8.4 84.9 19.5 18.5 43.5 16.6 12.8 12.1 11.9 7.8 23.6 18.4 8.2 6.9 20.3 13.2 11.3 5.9 4.5 11.2 13.9 7.9 12.4 7.0 11.5 24.0 5.7 2.6 19.1 9.8 20.2 24.0 15.1 11.1 14.6 8.1 28.1 7.8 15.1 11.7 11.3 8.4 9.2 8.9 11.4 10.6 9.9 7.1 12.0 2.4 12.3 7.8 5.4 10.3 8.7 4.9 5.2 5.2 6.1 4.7 5.2 5.3 5.0 5.4 5.0 5.7 5.4 13.6 3.2 10.3 9.1 8.1 5.1 4.9 13.5 2.8 3.2 7.0 4.6 17.4 7.2 12.8 5.5 4.2 6.2 12.4 19.1 27.4 9.6 7.0 10.6 7.4 12.9 6.7 36.7 7.9 17.9 7.5 4.6 8.2 6.0 3.8 3.3 9.7 15.4 9.0 1.7 8.4 9.0 30.5 4.1 3.6 10.0 2.8 7.3 14.2 4.7 6.7 10.3 18.6 7.1 11.6 16.6 8.0 7.5 23.5 5.6 14.7 24.7 17.2 5.0 0.0 4.5 6.9 2.4 3.9 5.9 5.3 10.4 12.0 6.2 5.6 7.3 ATG4B "APG4B, AUTL1, DKFZp586D1822, KIAA0943" ENSG00000168397 "Autophagy related 4B cysteine peptidase" Q9Y4P1 2 241637213-241673857 "Enzymes, Predicted intracellular proteins, Transporters" "Autophagy, Protein transport, Transport, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB037195, HPA069803" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 35: Non-specific - Unknown function" "Cluster 14: REH - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Cytosol" "CAB037195: AB_1078237, HPA069803: AB_2686200" "unprognostic (1.51e-1)" "unprognostic (8.80e-2)" "prognostic unfavorable (6.85e-4)" "unprognostic (1.51e-1)" "unprognostic (2.43e-2)" "unprognostic (2.67e-3)" "unprognostic (1.07e-3)" "unprognostic (1.06e-1)" "unprognostic (1.61e-1)" "unprognostic (1.58e-1)" "unprognostic (1.15e-3)" "unprognostic (3.02e-2)" "prognostic unfavorable (2.79e-4)" "unprognostic (2.60e-1)" "unprognostic (6.63e-2)" "unprognostic (1.66e-1)" "prognostic favorable (9.64e-4)" 12.0 17.5 21.4 8.1 21.7 14.7 13.2 20.9 24.7 18.0 20.1 19.7 11.4 16.8 5.3 16.2 16.8 7.6 18.4 21.6 23.0 19.7 18.0 12.4 13.2 23.0 21.4 16.5 16.4 12.1 21.5 7.2 23.6 22.6 5.4 8.5 14.4 9.6 18.7 16.7 18.3 6.7 20.7 19.9 16.1 19.7 22.4 16.1 18.7 7.6 7.8 16.3 14.6 21.5 8.8 15.6 16.9 13.5 15.8 10.5 29.5 23.8 9.8 16.5 12.4 15.0 9.8 7.4 7.2 11.8 10.5 16.5 16.0 20.3 3.8 18.8 31.8 19.6 14.1 40.2 20.1 13.6 12.0 13.8 15.0 9.0 7.1 16.8 11.0 44.3 23.4 5.1 8.6 32.6 33.4 36.9 30.9 23.8 25.9 51.3 25.1 16.2 11.4 14.9 26.2 21.3 17.5 13.9 27.8 14.1 15.5 24.6 15.4 7.1 12.0 14.8 13.3 21.1 17.0 34.6 18.8 21.4 17.6 3.9 17.9 19.2 18.5 15.6 15.9 15.8 14.2 15.6 20.4 16.5 18.0 12.8 12.8 11.8 18.9 17.0 20.4 16.8 21.4 21.7 20.9 24.7 21.6 23.0 23.0 21.4 23.6 20.7 22.4 21.5 23.2 32.1 33.8 41.1 25.6 24.3 27.2 41.3 25.0 22.2 24.4 21.8 16.2 25.8 29.9 27.6 33.3 35.8 33.5 61.8 19.6 37.5 18.1 28.6 21.9 25.3 35.9 31.8 38.5 40.2 28.5 22.6 40.8 43.3 19.0 36.5 20.3 27.9 33.4 42.1 33.8 36.4 42.7 28.5 34.5 25.9 22.1 30.7 28.4 31.9 51.2 24.5 41.2 20.1 41.0 41.5 41.5 24.8 28.6 35.6 70.5 25.1 26.7 26.8 19.7 22.7 22.8 58.3 63.3 19.9 25.4 53.9 29.4 27.6 35.6 32.5 ATG4C "APG4C, AUTL1, AUTL3, FLJ14867" ENSG00000125703 "Autophagy related 4C cysteine peptidase" Q96DT6 1 62784132-62865516 "Enzymes, Predicted intracellular proteins" "Autophagy, Protein transport, Transport, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 4 "brain: 60.8" "Cell type enriched" "Detected in all" 7 "Oligodendrocytes: 449.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007049 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 70: Brain - Nervous system development" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Nucleoplasm, Cytosol" "HPA007049: AB_1845159" "unprognostic (1.28e-1)" "unprognostic (2.69e-1)" "prognostic favorable (9.83e-4)" "unprognostic (7.43e-2)" "unprognostic (1.17e-1)" "unprognostic (1.70e-1)" "unprognostic (3.76e-2)" "unprognostic (8.36e-2)" "unprognostic (1.83e-2)" "unprognostic (1.30e-1)" "unprognostic (3.77e-1)" "unprognostic (1.93e-1)" "unprognostic (5.66e-2)" "unprognostic (1.81e-1)" "unprognostic (4.17e-2)" "unprognostic (3.26e-2)" "unprognostic (1.19e-1)" 7.9 8.0 23.3 10.3 41.1 5.8 7.8 25.0 24.0 8.5 6.3 8.4 6.7 8.0 5.9 7.2 6.5 8.8 6.0 19.7 25.0 11.2 11.1 8.1 13.3 28.5 29.9 8.3 7.5 10.8 3.3 12.8 29.3 6.5 8.7 6.6 9.8 6.2 5.2 5.5 6.6 9.4 23.7 12.1 7.7 8.1 26.5 13.7 9.9 5.2 10.9 8.3 3.9 60.8 11.5 8.9 13.5 11.9 17.4 18.5 13.5 16.6 11.3 15.7 17.5 6.5 8.8 23.9 12.5 8.5 18.3 8.6 16.1 12.7 22.5 18.0 15.0 27.2 9.3 8.7 12.4 22.2 17.4 15.5 8.9 16.7 7.9 15.1 19.1 26.3 23.4 19.1 13.4 5.4 22.5 8.5 19.8 16.2 14.5 26.5 32.2 17.2 11.2 8.1 18.2 9.1 11.0 20.6 22.1 23.2 10.0 10.3 7.6 12.5 12.2 21.3 18.4 16.3 24.0 20.0 14.3 21.5 15.4 32.6 17.4 14.1 7.2 14.1 10.1 34.3 10.2 8.9 31.9 30.8 14.1 12.0 2.5 12.5 8.6 19.0 9.8 11.5 23.3 41.1 25.0 24.0 19.7 25.0 28.5 29.9 29.3 23.7 26.5 60.8 12.6 6.4 10.6 50.3 29.7 5.0 6.2 9.9 6.8 5.2 5.8 5.8 10.0 5.7 9.7 7.3 2.1 37.7 14.1 3.7 19.6 7.2 8.1 5.5 10.2 12.8 6.0 15.8 42.0 8.1 30.7 12.2 8.2 4.9 12.0 7.8 12.8 10.0 36.5 5.0 40.8 4.3 4.1 17.9 7.3 3.0 8.7 25.1 8.8 58.1 29.7 10.5 9.2 57.8 449.9 4.8 4.2 9.8 24.2 3.5 4.8 24.8 4.8 5.2 6.6 8.3 8.3 37.2 14.6 6.6 4.0 29.0 9.2 9.1 6.6 3.6 ATG4D "APG4-D, APG4D, AUTL4" ENSG00000130734 "Autophagy related 4D cysteine peptidase" Q86TL0 19 10543895-10553418 "Enzymes, Predicted intracellular proteins, Transporters" "Apoptosis, Autophagy, Protein transport, Transport, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 103.9;Proximal enterocytes: 109.3;Spermatocytes: 100.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "NB-4: 57.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA067683 Approved Supported Nucleoplasm,Mitochondria NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 24: NB-4 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Mitochondria" "HPA067683: AB_2685886" "unprognostic (2.85e-1)" "prognostic favorable (3.18e-5)" "unprognostic (2.73e-1)" "unprognostic (3.67e-1)" "unprognostic (2.18e-1)" "unprognostic (1.15e-2)" "unprognostic (3.52e-2)" "unprognostic (1.23e-1)" "unprognostic (4.28e-2)" "unprognostic (7.30e-2)" "prognostic favorable (9.95e-4)" "unprognostic (1.52e-1)" "prognostic favorable (2.39e-7)" "prognostic favorable (5.03e-4)" "unprognostic (3.78e-2)" "unprognostic (2.29e-1)" "unprognostic (3.18e-3)" 7.3 15.6 4.2 7.3 4.7 33.2 7.4 8.3 8.6 9.4 8.2 22.3 21.8 8.1 1.6 27.3 7.6 3.9 23.2 4.5 4.0 20.8 13.2 10.6 8.3 5.2 4.7 9.5 16.3 10.7 16.6 4.9 5.3 14.0 5.2 2.5 16.6 4.4 36.9 24.6 23.2 2.1 3.1 17.0 13.7 24.5 5.4 12.0 13.4 10.8 4.6 9.7 15.0 6.1 13.8 8.7 11.7 16.5 2.1 1.8 9.9 9.2 7.8 11.1 12.2 14.9 4.3 9.2 16.2 0.9 8.6 20.8 7.3 6.8 1.4 10.4 23.5 23.1 22.3 8.2 7.4 9.4 22.1 1.8 14.2 9.8 3.4 2.8 3.3 18.1 17.8 19.8 3.6 21.9 27.6 57.8 18.9 6.1 29.0 20.0 8.2 15.1 6.4 17.8 45.3 17.8 12.6 22.6 11.3 2.1 14.0 21.6 6.4 16.8 11.0 34.7 20.4 19.2 15.4 10.8 14.4 18.0 19.5 1.6 0.8 3.7 1.1 1.0 1.5 1.0 1.3 1.2 0.6 0.4 1.2 1.7 0.2 1.3 0.4 4.2 2.2 0.8 4.2 4.7 8.3 8.6 4.5 4.0 5.2 4.7 5.3 3.1 5.4 6.1 6.3 9.6 6.6 9.1 14.4 30.5 19.8 14.9 24.5 14.9 14.1 10.2 0.5 14.3 8.1 1.8 14.6 27.9 38.7 103.9 13.7 16.1 83.6 9.6 5.5 5.3 22.2 43.6 8.4 16.5 6.7 8.2 26.5 10.1 7.0 10.9 6.1 11.9 13.4 28.6 9.1 38.5 20.3 15.0 12.1 16.3 8.7 10.0 12.4 4.7 15.7 11.8 22.6 4.5 8.4 20.5 72.4 4.5 17.6 21.6 109.3 25.4 5.2 20.1 13.1 9.1 14.2 100.7 21.2 33.4 31.3 36.5 19.6 10.6 33.2 36.4 ATP23 "KUB3, XRCC6BP1" ENSG00000166896 "ATP23 metallopeptidase and ATP synthase assembly factor homolog" Q9Y6H3 12 57906039-57959148 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 27.8" "Cell type enhanced" "Detected in many" "Breast myoepithelial cells: 12.7;Cytotrophoblasts: 14.4;Distal tubular cells: 17.6;Extravillous trophoblasts: 15.2;Proximal tubular cells: 26.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in single" "Immune cell enriched" "Detected in single" 4 "neutrophil: 1.6" "Lineage enriched" "Detected in single" 4 "granulocytes: 1.6" "Cell line enhanced" "Detected in some" "A549: 1.0;Karpas-707: 2.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035804, HPA043204" Uncertain Enhanced "Vesicles,Plasma membrane,Cell Junctions,Cytosol" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 71: Testis - DNA repair" "Cluster 2: Karpas-707 - Immune response" "Cluster 7: Non-specific - Mitochondria" "Vesicles, Plasma membrane" "Cell Junctions, Cytosol" "HPA035804: AB_10601026, HPA043204: AB_2678361" "unprognostic (2.56e-1)" "unprognostic (1.31e-2)" "unprognostic (8.82e-2)" "unprognostic (2.92e-2)" "unprognostic (2.30e-2)" "unprognostic (6.16e-2)" "unprognostic (1.20e-1)" "unprognostic (5.28e-2)" "unprognostic (5.41e-3)" "unprognostic (1.03e-2)" "unprognostic (1.24e-1)" "unprognostic (1.06e-1)" "prognostic unfavorable (1.44e-5)" "unprognostic (4.36e-2)" "unprognostic (1.12e-1)" "unprognostic (1.80e-1)" "unprognostic (2.27e-1)" 7.5 4.9 0.6 0.4 0.5 0.1 5.6 0.6 0.9 4.1 0.5 8.1 0.2 3.1 0.0 5.6 3.2 0.0 4.6 1.0 0.3 4.0 5.2 2.6 0.1 0.4 0.2 3.1 5.9 0.0 2.8 0.1 0.4 3.3 0.0 0.5 3.6 0.0 12.4 4.4 4.3 0.0 0.3 3.2 4.2 27.8 0.5 0.0 3.5 0.0 0.1 4.7 4.0 0.3 0.6 1.0 0.0 0.3 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.5 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.2 0.0 0.9 0.2 0.0 0.0 0.4 0.1 0.0 0.3 0.0 0.1 0.0 0.0 0.6 2.6 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.3 0.6 0.8 0.1 0.0 0.4 0.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.4 0.3 0.0 0.4 0.0 0.0 0.4 0.0 0.6 0.1 0.2 0.0 0.2 0.2 0.2 0.2 0.1 0.3 0.0 0.3 0.2 0.2 1.6 0.1 0.1 0.1 0.1 0.0 0.6 0.5 0.6 0.9 1.0 0.3 0.4 0.2 0.4 0.3 0.5 0.3 8.0 0.0 9.2 0.0 2.3 0.0 0.0 0.0 0.0 0.0 7.4 12.7 0.0 0.0 1.8 3.7 0.0 14.4 4.2 0.0 17.6 6.1 0.0 5.6 4.9 2.8 0.0 0.0 0.0 10.7 15.2 2.3 0.0 6.0 11.4 6.8 0.0 0.0 10.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.2 0.0 0.0 1.0 0.0 0.0 0.0 0.0 3.7 0.0 0.0 0.9 0.0 0.0 26.1 0.7 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 3.4 3.0 9.5 0.0 0.0 AZU1 "AZAMP, AZU, CAP37, HBP, HUMAZUR, NAZC" ENSG00000172232 "Azurocidin 1" P20160 19 825097-832018 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" Chemotaxis "Antibiotic, Antimicrobial, Heparin-binding, Serine protease homolog" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 48 "bone marrow: 1578.1" "Cell type enhanced" "Detected in some" "Breast glandular cells: 4.5;Breast myoepithelial cells: 4.6;Endometrial ciliated cells: 8.9;Erythroid cells: 8.8;Respiratory ciliated cells: 4.5;Skeletal myocytes: 5.7;Spermatogonia: 6.4" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 9 "neutrophil: 3.3" "Lineage enriched" "Detected in single" 9 "granulocytes: 3.3" "Cell line enriched" "Detected in some" 15 "THP-1: 659.5" "Not detected" "Not detected" "HPA055851, HPA075964" Enhanced Enhanced Vesicles "Secreted to blood" NA NA 320000 "Cluster 1: Neutrophils - Mixed function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 43: THP-1 - Innate immune response" "Cluster 49: Ciliated cells - Cilium organization" Vesicles "HPA055851: AB_2682943, HPA075964: " "unprognostic (1.12e-2)" "unprognostic (3.71e-2)" "unprognostic (4.44e-2)" "unprognostic (8.85e-3)" "unprognostic (1.62e-2)" "unprognostic (1.29e-1)" "unprognostic (1.39e-1)" "unprognostic (8.12e-2)" "unprognostic (3.32e-1)" "unprognostic (4.22e-3)" "unprognostic (2.58e-1)" "unprognostic (1.50e-1)" "unprognostic (1.01e-6)" "unprognostic (1.11e-2)" "unprognostic (1.10e-1)" "unprognostic (2.46e-2)" "unprognostic (3.04e-2)" 0.8 0.2 0.4 0.0 0.4 1578.1 1.5 0.2 0.9 0.2 0.2 0.2 0.0 0.5 0.0 0.1 1.4 0.0 2.0 0.4 0.3 0.4 2.8 15.9 0.6 0.3 0.3 0.2 0.2 0.0 0.9 0.9 0.4 0.4 0.0 0.0 2.6 0.0 0.5 0.6 0.2 0.0 0.2 33.1 0.2 2.4 0.4 3.1 0.5 0.0 0.0 0.3 0.2 0.3 1.1 0.2 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 2.3 0.0 0.6 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.3 0.0 44.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.6 0.4 0.6 659.5 0.0 0.0 0.1 0.0 0.8 0.0 0.1 0.6 0.0 34.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 3.3 0.0 0.1 0.0 0.0 0.1 0.4 0.4 0.2 0.9 0.4 0.3 0.3 0.3 0.4 0.2 0.4 0.3 3.5 0.0 0.0 0.0 0.6 0.0 0.1 1.2 0.0 0.0 4.5 4.6 0.7 0.0 0.5 0.0 0.0 0.2 2.8 0.6 0.0 0.1 0.0 8.9 1.2 1.0 0.0 8.8 0.8 0.0 0.3 0.8 0.0 2.3 0.0 0.1 0.0 0.4 3.2 0.0 1.4 0.4 0.0 3.7 0.4 0.7 0.0 3.2 0.0 0.0 3.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.2 0.2 0.0 4.5 0.0 0.0 5.7 1.2 0.1 6.4 0.9 0.1 0.0 1.0 0.0 0.6 0.0 BACE1 BACE ENSG00000186318 "Beta-secretase 1" P56817 11 117285207-117316259 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Aspartyl protease, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 4 "brain: 119.1;pancreas: 271.5" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 118.9;Early spermatids: 99.9;Late spermatids: 343.0;Oligodendrocytes: 99.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 88.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB016358 Approved Supported "Plasma membrane" NA NA "Cluster 22: Non-specific - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 31: Spermatids - Spermatogenesis" "Plasma membrane" "CAB016358: AB_626716" "unprognostic (7.96e-3)" "unprognostic (8.05e-2)" "unprognostic (3.55e-2)" "unprognostic (3.05e-3)" "unprognostic (8.94e-2)" "unprognostic (3.39e-1)" "unprognostic (1.03e-1)" "unprognostic (2.60e-1)" "unprognostic (4.54e-2)" "unprognostic (8.04e-2)" "unprognostic (8.09e-2)" "unprognostic (1.09e-1)" "unprognostic (1.12e-1)" "unprognostic (1.35e-2)" "unprognostic (1.16e-1)" "unprognostic (1.27e-1)" "prognostic unfavorable (6.76e-4)" 15.4 16.0 34.3 8.0 68.5 3.3 11.7 68.7 44.0 18.3 11.9 13.7 6.1 19.7 8.8 13.5 15.9 19.1 11.4 34.3 44.5 14.8 25.6 14.4 5.1 89.7 67.0 20.5 271.5 18.5 10.7 13.8 76.6 13.4 7.6 44.7 11.0 18.3 12.5 11.4 7.7 21.3 61.6 12.4 9.8 11.2 59.9 3.8 12.2 9.1 5.0 12.4 14.3 119.1 11.5 10.7 22.9 37.3 80.9 82.3 1.0 62.9 44.4 24.4 19.0 4.5 16.4 1.4 14.6 88.3 18.4 17.9 24.3 12.1 20.5 3.1 12.1 6.0 17.3 5.1 36.5 2.5 1.7 68.1 20.2 29.7 31.8 68.0 21.4 3.8 2.7 1.1 46.5 33.4 2.5 2.1 15.5 10.6 25.9 6.4 11.6 1.6 12.2 5.9 31.7 36.7 22.5 2.6 5.9 23.5 26.2 7.6 31.4 45.2 5.0 48.2 19.4 0.7 1.0 1.1 23.8 2.0 34.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 34.3 68.5 68.7 44.0 34.3 44.5 89.7 67.0 76.6 61.6 59.9 119.1 12.1 19.2 10.1 16.3 0.3 4.7 4.1 3.4 9.1 53.7 8.7 9.0 8.7 18.6 13.3 5.5 118.9 1.0 0.1 2.0 5.9 7.4 99.9 5.1 32.1 8.3 21.7 1.7 24.9 20.0 1.3 19.5 3.1 8.9 2.5 15.8 6.8 38.6 9.4 57.2 32.0 5.1 2.0 17.2 7.7 343.0 19.3 7.9 3.6 14.0 4.0 17.9 0.0 22.1 99.8 4.3 6.3 22.2 0.1 2.4 1.7 6.3 3.4 55.2 6.6 18.1 14.2 3.4 1.7 10.6 3.4 0.8 1.2 68.0 4.5 3.4 BACE2 "AEPLC, ALP56, CEAP1, DRAP" ENSG00000182240 "Beta-secretase 2" Q9Y5Z0 21 41167801-41282530 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Aspartyl protease, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "salivary gland: 26.8" "Cell type enhanced" "Detected in many" "Prostatic glandular cells: 290.4;Syncytiotrophoblasts: 514.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 6 "basophil: 2.9;eosinophil: 5.2" "Lineage enriched" "Detected in single" 8 "granulocytes: 5.2" "Cell line enhanced" "Detected in many" "OE19: 73.8;SK-BR-3: 53.3;SK-MEL-30: 52.6;WM-115: 46.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA035416 Approved "Intracellular and membrane" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 17: WM-115 - Nervous system development" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" "HPA035416: AB_2732467" "unprognostic (1.71e-2)" "prognostic unfavorable (1.11e-4)" "unprognostic (5.23e-2)" "unprognostic (8.12e-3)" "prognostic unfavorable (5.86e-4)" "unprognostic (1.52e-2)" "unprognostic (2.58e-2)" "unprognostic (2.64e-3)" "unprognostic (7.24e-2)" "unprognostic (2.49e-1)" "unprognostic (3.46e-2)" "unprognostic (8.50e-2)" "unprognostic (1.22e-1)" "unprognostic (4.04e-1)" "unprognostic (2.10e-1)" "unprognostic (2.76e-2)" "unprognostic (5.83e-2)" 10.0 1.6 2.1 4.3 3.1 0.6 7.7 4.4 2.6 6.1 9.4 7.3 3.5 8.7 1.9 9.4 6.3 8.3 6.2 2.0 4.1 9.8 1.7 4.3 3.1 6.7 3.8 2.7 13.1 2.3 1.5 2.9 5.1 8.3 4.5 0.3 26.8 2.6 2.2 5.0 4.5 4.7 5.5 4.7 22.9 1.0 4.1 1.1 4.6 2.2 3.6 6.7 5.6 8.7 27.4 2.1 12.6 0.0 2.5 2.1 0.1 6.3 0.0 3.9 3.8 0.0 9.6 0.1 12.2 7.1 7.2 8.1 0.0 13.6 1.4 0.0 12.6 6.2 3.3 0.0 1.0 0.0 14.4 5.5 2.8 0.5 2.7 20.9 12.1 6.4 0.0 0.1 6.0 6.1 3.4 0.0 8.5 73.8 12.1 1.0 0.0 9.8 11.5 2.5 0.4 0.1 0.5 53.3 52.6 1.0 12.0 0.1 15.8 7.3 5.3 6.5 10.9 0.1 0.1 0.0 17.8 0.0 46.2 2.9 0.0 5.2 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 2.1 3.1 4.4 2.6 2.0 4.1 6.7 3.8 5.1 5.5 4.1 8.7 55.0 12.8 15.9 11.8 28.6 18.5 91.6 25.6 42.7 0.8 40.3 33.8 9.7 123.0 72.5 20.2 2.1 127.6 0.5 40.5 93.9 146.3 24.3 65.4 19.8 90.2 18.5 22.1 11.7 105.2 64.2 34.0 186.6 115.8 90.7 6.7 35.3 1.0 28.0 0.0 7.5 86.2 44.7 17.0 8.2 16.0 14.3 3.6 179.7 20.6 2.9 3.1 0.0 9.5 46.0 86.6 23.9 18.8 3.2 290.4 7.3 1.4 76.5 0.8 0.0 15.9 23.6 0.6 1.4 43.5 11.8 514.7 6.2 8.7 56.6 134.2 BAP1 "hucep-6, KIAA0272, UCHL2" ENSG00000163930 "BRCA1 associated protein 1" Q92560 3 52401008-52410008 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Chromatin regulator, Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 103.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004322, HPA028814, HPA028815, HPA055560" Approved Enhanced Nucleoplasm,Cytosol NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 34: Spermatids - Unknown function" Nucleoplasm Cytosol "CAB004322: AB_626723, HPA028814: AB_10602393, HPA028815: AB_2672785, HPA055560: AB_2682850" "unprognostic (1.52e-1)" "unprognostic (7.96e-2)" "unprognostic (1.96e-2)" "unprognostic (6.04e-2)" "unprognostic (1.74e-1)" "unprognostic (2.55e-2)" "unprognostic (9.41e-3)" "unprognostic (8.53e-3)" "unprognostic (1.33e-1)" "unprognostic (3.15e-1)" "unprognostic (4.64e-3)" "unprognostic (3.30e-3)" "prognostic favorable (3.29e-7)" "unprognostic (6.37e-2)" "unprognostic (1.91e-1)" "unprognostic (5.54e-2)" "unprognostic (2.92e-1)" 45.2 63.5 97.6 25.0 99.2 73.9 42.9 78.9 135.5 39.1 71.4 47.7 21.6 40.5 23.1 59.3 36.0 25.7 57.0 114.1 83.3 57.3 65.2 46.0 29.4 81.2 85.7 43.9 52.7 40.2 36.9 24.6 81.7 50.0 24.1 20.1 43.0 22.5 74.7 73.4 43.4 23.8 79.9 54.2 48.1 140.0 89.2 33.1 49.1 43.5 27.9 44.6 41.7 90.5 39.1 43.1 52.2 44.8 50.1 31.4 59.3 37.8 50.1 62.4 48.0 52.5 35.8 55.7 18.3 54.7 69.3 31.4 55.7 63.0 37.9 55.1 51.4 68.6 94.4 53.2 45.7 65.6 58.5 48.0 80.1 68.5 36.1 33.3 50.3 107.7 59.9 48.3 44.5 33.7 79.1 89.5 58.0 31.0 52.8 33.7 41.7 55.8 37.4 61.2 19.8 63.6 46.1 13.7 56.9 29.2 37.7 90.6 52.5 54.1 49.3 66.0 70.9 71.7 101.6 81.2 58.5 68.2 66.1 2.9 3.2 5.4 5.4 2.8 2.6 3.2 4.3 4.4 2.2 4.1 3.1 4.0 7.4 2.2 2.2 5.6 4.2 2.7 97.6 99.2 78.9 135.5 114.1 83.3 81.2 85.7 81.7 79.9 89.2 90.5 13.5 0.0 16.0 8.1 12.2 31.6 10.5 13.2 23.3 16.6 16.4 12.6 23.6 11.5 10.2 25.8 0.0 14.0 17.7 23.2 11.7 13.5 103.4 9.2 12.4 14.7 10.8 8.2 7.5 16.7 15.8 13.6 14.8 13.6 21.0 18.1 14.6 29.2 12.6 10.1 7.7 16.6 6.1 17.4 10.7 48.0 10.2 12.0 12.4 5.6 15.2 16.1 16.5 7.1 6.7 15.8 16.5 11.7 16.2 11.7 13.3 18.5 8.2 12.3 19.7 14.7 14.2 37.8 13.9 23.0 23.4 12.0 12.2 15.9 19.8 9.6 BLMH BH ENSG00000108578 "Bleomycin hydrolase" Q13867 17 30248203-30292056 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skin 1: 130.3" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039548, HPA064307" Enhanced Supported "Nucleoplasm,Nuclear bodies,Cytosol" No No 42000000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 24: Non-specific - Transcription regulation" "Nucleoplasm, Nuclear bodies, Cytosol" "HPA039548: AB_10805479, HPA064307: AB_2685241" "unprognostic (6.85e-2)" "unprognostic (2.79e-1)" "unprognostic (1.48e-1)" "unprognostic (2.46e-1)" "unprognostic (1.76e-1)" "unprognostic (2.54e-2)" "unprognostic (3.91e-3)" "unprognostic (2.07e-1)" "unprognostic (2.05e-3)" "unprognostic (6.69e-3)" "unprognostic (1.95e-3)" "unprognostic (2.14e-2)" "unprognostic (2.14e-2)" "unprognostic (1.22e-3)" "unprognostic (1.05e-1)" "unprognostic (1.34e-1)" "unprognostic (1.44e-1)" 20.6 13.5 13.4 18.2 15.0 18.1 20.4 15.9 17.6 19.1 14.5 18.8 12.4 21.2 21.1 28.3 14.7 18.4 15.6 13.5 15.2 22.0 14.0 16.0 26.0 15.6 14.1 13.9 26.8 21.7 9.7 27.4 15.4 14.4 15.4 14.7 15.6 14.4 28.8 130.3 18.3 22.4 14.7 20.6 16.2 15.9 14.2 36.3 16.5 19.0 26.9 17.9 21.5 16.2 40.3 62.9 61.5 41.6 40.6 43.8 27.8 36.5 24.0 59.1 50.8 93.2 11.9 119.5 63.3 31.1 26.1 27.1 135.5 52.8 50.1 31.5 101.4 73.5 54.6 80.0 58.3 136.1 43.2 50.5 3.5 46.5 26.5 47.1 87.2 98.2 157.9 47.6 24.6 31.0 168.1 98.6 57.2 0.0 29.2 143.0 154.5 78.9 46.8 35.6 135.1 48.4 32.6 63.2 42.2 106.6 42.9 68.5 54.5 35.0 69.2 16.0 66.0 55.8 124.1 159.3 26.7 0.2 47.6 0.0 8.8 1.5 15.3 6.2 25.3 6.5 18.2 20.2 10.1 7.3 16.4 17.8 1.2 16.3 3.3 10.1 20.0 9.9 13.4 15.0 15.9 17.6 13.5 15.2 15.6 14.1 15.4 14.7 14.2 16.2 21.0 3.2 12.6 13.4 8.8 15.9 16.7 10.6 19.4 20.2 10.3 6.6 17.8 12.8 4.0 11.0 12.5 49.6 15.6 7.6 7.9 17.4 8.4 7.4 28.2 24.0 18.0 22.5 19.0 14.2 38.0 18.3 11.2 7.0 43.8 30.5 25.7 6.9 25.0 13.5 20.9 8.4 6.1 18.9 7.1 6.6 16.1 13.0 10.6 18.7 12.2 9.9 22.6 29.1 22.6 7.2 9.6 24.8 20.0 13.0 11.5 20.0 5.5 15.7 6.6 12.9 19.7 14.9 29.1 24.0 12.6 27.5 20.9 34.8 11.5 7.6 BRCC3 "BRCC36, C6.1A, CXorf53" ENSG00000185515 "BRCA1/BRCA2-containing complex subunit 3" P46736 X 155071420-155123077 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Ubl conjugation pathway" "Chromatin regulator, Hydrolase, Metalloprotease, Protease" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA048737 Supported Nucleoplasm NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA048737: AB_2680504" "unprognostic (1.16e-2)" "unprognostic (2.40e-2)" "unprognostic (5.99e-2)" "unprognostic (1.53e-1)" "unprognostic (1.43e-1)" "unprognostic (2.88e-2)" "unprognostic (4.48e-2)" "unprognostic (6.47e-3)" "unprognostic (1.33e-1)" "unprognostic (9.68e-2)" "unprognostic (1.35e-3)" "unprognostic (3.72e-2)" "unprognostic (3.71e-3)" "unprognostic (7.14e-3)" "unprognostic (1.57e-1)" "unprognostic (1.17e-1)" "unprognostic (1.90e-1)" 9.9 12.9 6.8 12.1 6.6 15.6 15.8 9.2 7.7 12.8 6.8 22.3 19.3 9.2 18.5 18.4 11.6 8.4 11.2 6.6 7.0 17.8 13.8 9.8 15.4 5.9 7.1 8.1 11.4 14.7 5.2 14.0 6.7 14.6 23.3 12.9 18.5 10.9 17.8 11.1 16.9 10.6 5.4 11.0 15.6 2.3 7.4 13.4 15.2 17.6 15.5 12.6 6.3 6.6 95.6 45.1 24.4 19.6 20.9 17.7 37.9 35.9 25.8 24.1 52.3 44.0 40.1 84.1 62.8 22.1 36.1 36.3 54.4 33.6 38.0 45.4 42.1 17.7 76.1 41.4 15.8 62.8 25.5 17.3 16.9 35.1 28.5 23.1 30.1 32.2 27.4 24.9 24.6 33.6 25.8 28.8 22.3 101.9 41.9 36.2 43.3 42.0 36.8 36.5 38.0 17.3 25.6 43.6 27.3 31.5 25.2 33.7 31.5 20.4 32.1 27.6 53.8 30.0 56.1 114.5 28.2 61.5 25.3 36.8 18.8 34.0 20.0 22.9 23.4 17.6 19.3 18.2 21.2 16.7 14.8 16.6 10.5 28.4 24.1 13.3 25.4 16.9 6.8 6.6 9.2 7.7 6.6 7.0 5.9 7.1 6.7 5.4 7.4 6.6 12.0 32.1 23.3 16.6 14.0 5.5 7.0 13.8 6.8 13.0 15.0 14.0 27.2 10.0 28.5 7.3 14.6 26.7 17.6 25.5 19.6 22.9 0.6 13.8 13.7 10.6 9.6 17.1 31.9 19.8 26.6 11.3 12.8 15.9 26.6 13.7 8.6 8.6 17.4 8.4 35.2 22.6 16.2 9.5 7.0 1.3 5.9 14.5 5.4 15.9 22.3 12.9 20.6 26.7 29.2 14.7 16.8 12.0 21.1 10.3 16.3 18.0 25.1 14.5 19.7 12.6 22.9 1.2 1.3 26.2 6.5 13.5 14.9 18.3 27.3 8.3 C1RL "C1r-LP, C1RL1" ENSG00000139178 "Complement C1r subcomponent like" Q9NZP8 12 7089587-7109238 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Complement pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 141.9" "Cell type enhanced" "Detected in many" "Exocrine glandular cells: 54.2;Hepatocytes: 140.0;Leydig cells: 55.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 5.4" "Lineage enriched" "Detected in many" 4 "granulocytes: 5.4" "Cell line enhanced" "Detected in many" "ASC TERT1: 38.2;HSkMC: 43.1" "Not detected" "Not detected" "Low region specificity" "Detected in some" "HPA011338, CAB026172" Supported "Secreted to blood" NA NA 5500000000 15000000000 "Cluster 49: Eosinophils - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 2: Hepatocytes - Metabolism" "CAB026172: , HPA011338: AB_1847111" "prognostic favorable (7.92e-4)" "unprognostic (7.76e-2)" "unprognostic (3.91e-3)" "unprognostic (5.25e-3)" "unprognostic (2.92e-3)" "unprognostic (9.60e-2)" "unprognostic (2.75e-3)" "unprognostic (7.76e-2)" "unprognostic (1.22e-1)" "unprognostic (4.34e-1)" "unprognostic (9.58e-3)" "unprognostic (1.57e-1)" "prognostic unfavorable (1.52e-7)" "unprognostic (1.75e-1)" "unprognostic (5.74e-2)" "unprognostic (2.52e-1)" "unprognostic (2.26e-3)" 38.3 72.5 3.4 12.2 3.3 8.2 36.5 2.6 3.1 38.6 7.1 28.8 7.6 30.2 6.3 17.5 40.8 11.7 18.4 2.7 4.0 20.1 141.9 33.1 9.5 7.4 5.0 49.4 36.7 8.0 17.5 5.1 4.4 29.3 8.7 1.5 33.7 6.9 11.0 18.1 26.3 13.7 3.7 32.3 27.5 6.1 3.9 6.9 21.7 6.0 7.7 38.1 27.5 3.3 3.0 7.7 0.7 7.9 22.4 38.2 5.4 4.9 22.7 5.0 14.8 4.9 13.4 1.3 4.1 4.1 5.0 6.4 2.1 8.1 1.9 12.0 0.4 4.8 8.5 11.4 18.7 1.0 21.9 43.1 15.7 3.0 9.3 23.3 5.3 2.8 3.6 3.1 3.1 0.1 0.7 0.9 1.4 0.6 0.2 2.7 0.0 1.0 13.1 13.2 0.6 1.7 16.7 2.0 2.8 1.3 1.9 4.1 5.0 4.3 7.7 4.9 0.9 2.3 1.0 0.2 8.1 3.4 2.0 3.8 0.7 4.0 0.6 1.1 0.3 1.2 0.6 0.5 0.8 0.5 0.4 0.4 5.4 0.3 1.3 0.4 0.4 0.4 3.4 3.3 2.6 3.1 2.7 4.0 7.4 5.0 4.4 3.7 3.9 3.3 11.0 16.0 38.6 7.5 8.4 3.8 15.4 16.4 25.6 0.5 15.6 14.5 2.6 30.0 24.6 5.5 2.1 0.2 7.3 8.3 1.9 36.3 0.1 7.9 22.6 14.6 4.2 7.8 10.2 54.2 0.4 29.0 27.5 10.4 3.8 13.8 25.0 140.0 3.6 0.0 1.3 7.7 10.2 10.0 4.9 3.0 55.6 10.2 3.6 14.0 13.3 4.0 21.6 2.0 0.4 25.8 9.7 20.3 8.0 10.2 9.3 8.2 15.9 1.1 0.0 11.8 10.1 0.6 0.9 8.5 3.1 0.1 9.7 13.6 9.5 8.7 C1S ENSG00000182326 "Complement C1s" P09871 12 6988259-7071032 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Complement pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Disease variant, Ehlers-Danlos syndrome, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 5 "liver: 2915.2" "Cell type enhanced" "Detected in many" "Fibroblasts: 687.0;Hepatocytes: 2795.1;Leydig cells: 1193.2;Peritubular cells: 640.1" "Cancer enhanced" "Detected in all" "liver cancer: 276.7" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 7 "neutrophil: 2.2" "Lineage enriched" "Detected in single" 18 "granulocytes: 2.2" "Cell line enhanced" "Detected in many" "ASC diff: 769.5;ASC TERT1: 1012.7;BJ hTERT+: 336.1;HSkMC: 540.2" "Not detected" "Not detected" "CAB016722, HPA018852" Supported Approved Nucleoplasm,Cytosol "Secreted to blood" NA NA 93000000000 14000000000 "Cluster 1: Neutrophils - Mixed function" "Cluster 62: Liver - Hemostasis" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 2: Hepatocytes - Metabolism" Nucleoplasm Cytosol "CAB016722: , HPA018852: AB_1847112" "unprognostic (2.72e-3)" "unprognostic (7.31e-2)" "unprognostic (9.37e-2)" "unprognostic (1.39e-2)" "unprognostic (1.05e-2)" "unprognostic (9.63e-2)" "prognostic favorable (7.73e-4)" "unprognostic (6.38e-2)" "unprognostic (1.16e-1)" "unprognostic (6.14e-2)" "unprognostic (1.57e-1)" "unprognostic (1.85e-2)" "prognostic unfavorable (7.44e-15)" "unprognostic (2.02e-2)" "unprognostic (5.68e-3)" "unprognostic (1.19e-2)" "unprognostic (5.39e-2)" 416.4 136.1 26.4 207.7 28.5 1.7 252.5 27.1 43.1 309.2 36.7 192.4 84.6 209.0 147.2 152.9 315.4 543.8 191.5 25.4 34.8 60.2 2915.2 224.9 209.2 44.3 31.7 485.9 62.1 21.8 33.1 52.9 31.2 174.4 215.2 9.7 96.9 139.1 57.0 104.1 154.2 251.8 30.9 168.5 150.1 90.0 30.9 88.1 139.0 154.7 192.5 455.7 189.8 31.3 0.2 18.6 1.2 10.2 769.5 1012.7 4.5 143.3 336.1 74.7 135.7 0.9 2.0 0.5 19.7 179.6 20.2 1.1 0.3 2.1 6.7 0.7 0.7 0.5 5.6 48.2 230.3 1.8 0.9 540.2 2.8 60.2 4.4 94.2 0.1 0.2 0.4 0.1 9.9 0.0 0.4 1.6 10.3 0.0 0.6 0.2 1.1 1.5 3.1 2.5 0.8 0.9 86.6 1.8 2.1 17.4 0.1 0.0 0.5 34.2 2.6 133.8 0.2 0.6 0.5 0.8 73.6 1.2 2.5 0.3 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 26.4 28.5 27.1 43.1 25.4 34.8 44.3 31.7 31.2 30.9 30.9 31.3 37.6 16.0 41.0 9.4 5.7 76.2 18.9 22.2 23.9 0.9 4.5 15.4 21.5 171.6 15.5 3.7 0.0 3.7 0.7 0.1 1.9 285.2 6.6 8.7 272.4 30.6 0.0 112.2 2.9 42.9 2.5 687.0 11.2 7.3 5.1 25.7 93.5 2795.1 8.1 5.0 1.7 0.0 2.0 62.8 103.7 29.9 1193.2 6.4 88.9 19.7 1.0 15.2 0.0 1.5 0.6 31.7 0.1 640.1 1.8 9.7 0.0 7.1 4.6 1.1 138.1 34.9 127.6 6.3 5.3 6.3 53.8 2.6 12.8 30.7 0.2 5.2 C2 ENSG00000166278 "Complement C2" P06681 6 31897785-31945672 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Complement pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Age-related macular degeneration, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "liver: 477.9" "Group enriched" "Detected in many" 4 "Alveolar cells type 2: 142.4;Hepatocytes: 380.3;Hofbauer cells: 282.7;Kupffer cells: 99.3" "Cancer enriched" "Detected in all" 9 "liver cancer: 100.2" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 4 "intermediate monocyte: 21.1;non-classical monocyte: 25.9" "Lineage enriched" "Detected in single" 35 "monocytes: 25.9" "Cell line enriched" "Detected in some" 5 "Karpas-707: 284.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" CAB016775 Supported "Secreted to blood" NA NA 34000000000 "Cluster 51: Monocytes - Innate immune response" "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 2: Karpas-707 - Immune response" "Cluster 15: Hepatocytes - Hemostasis" "CAB016775: " "unprognostic (2.05e-1)" "unprognostic (1.22e-1)" "unprognostic (7.68e-2)" "unprognostic (1.49e-3)" "unprognostic (7.40e-2)" "unprognostic (3.34e-2)" "unprognostic (1.36e-2)" "unprognostic (8.88e-3)" "unprognostic (3.02e-1)" "unprognostic (2.59e-3)" "unprognostic (3.27e-2)" "unprognostic (3.15e-3)" "prognostic unfavorable (2.64e-7)" "unprognostic (2.05e-1)" "unprognostic (4.42e-2)" "unprognostic (7.37e-2)" "unprognostic (2.55e-2)" 42.6 12.1 0.8 27.6 1.0 3.2 11.7 0.9 1.4 8.1 1.7 14.3 16.7 7.0 1.3 7.6 12.0 23.0 8.5 0.7 1.1 23.2 477.9 80.0 27.8 3.0 2.6 5.3 1.9 0.9 3.8 48.4 3.0 5.4 13.0 0.4 9.1 0.9 2.1 5.8 30.2 23.6 2.1 46.3 12.0 4.1 3.7 5.5 3.3 2.7 12.5 23.6 5.3 2.1 0.3 0.1 0.1 0.6 0.1 0.0 6.8 0.5 0.3 0.4 0.3 0.4 0.3 0.6 3.5 1.0 0.6 0.5 0.1 0.0 0.3 0.2 0.4 0.3 0.4 52.8 1.1 0.1 0.7 2.7 0.3 0.6 0.1 0.6 0.0 0.7 0.5 284.0 0.0 0.0 0.4 0.5 0.3 0.1 0.0 0.2 16.5 3.0 0.0 0.1 0.3 0.3 2.6 0.3 0.2 0.3 0.2 9.5 0.2 0.2 0.7 0.5 0.1 0.9 31.6 2.7 0.8 0.9 0.1 0.1 5.6 0.0 0.1 21.1 0.1 0.0 0.0 0.0 0.7 0.1 0.1 0.1 0.5 0.1 25.9 0.0 0.0 2.2 0.8 1.0 0.9 1.4 0.7 1.1 3.0 2.6 3.0 2.1 3.7 2.1 2.1 25.6 142.4 2.6 1.9 3.3 1.1 2.0 0.6 1.4 1.3 1.3 0.6 25.8 11.2 1.8 0.0 2.1 0.1 1.8 0.0 0.6 0.3 1.5 18.7 1.9 2.4 10.7 6.6 2.7 2.7 19.8 3.1 1.3 3.8 0.2 21.0 380.3 282.7 1.7 6.3 11.3 0.0 99.3 5.0 1.3 6.8 32.6 3.6 7.5 7.3 0.1 0.0 1.0 1.7 4.5 33.1 1.2 0.4 4.0 55.2 35.7 9.4 0.9 0.0 5.6 3.5 0.8 1.4 0.7 2.8 4.0 2.0 0.5 15.8 4.5 CAPN1 "CANP, CANPL1, muCANP, muCL" ENSG00000014216 "Calpain 1" P07384 11 65180566-65212006 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "esophagus: 276.2" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RT4: 516.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005992 Enhanced Supported Cytosol NA NA 9100000 "Cluster 46: Basophils - DNA binding" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 15: RT4 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "HPA005992: AB_1845924" "unprognostic (2.07e-1)" "unprognostic (2.15e-1)" "unprognostic (2.69e-1)" "unprognostic (1.40e-1)" "unprognostic (4.06e-2)" "unprognostic (1.10e-1)" "unprognostic (1.91e-2)" "unprognostic (2.48e-2)" "unprognostic (7.23e-2)" "unprognostic (2.23e-2)" "prognostic unfavorable (4.30e-4)" "unprognostic (3.33e-1)" "prognostic favorable (7.06e-8)" "unprognostic (5.70e-3)" "unprognostic (1.51e-1)" "unprognostic (1.86e-1)" "unprognostic (2.98e-1)" 44.8 43.1 27.8 51.9 26.1 66.5 48.4 29.7 30.1 80.9 28.3 78.6 80.4 56.3 27.5 276.2 92.3 55.5 53.1 27.7 33.0 53.1 44.3 56.9 57.0 41.4 31.5 44.5 71.7 36.6 40.8 56.2 43.4 62.1 57.6 9.6 118.7 67.4 84.8 125.1 88.1 45.3 33.9 50.2 65.5 6.1 37.9 49.5 71.5 55.3 86.4 83.4 117.4 27.4 285.6 147.9 42.9 97.2 77.9 104.3 127.0 84.1 144.2 103.0 74.9 94.8 250.2 71.2 136.0 179.3 111.1 409.8 60.9 366.9 32.2 76.4 44.1 170.8 80.4 93.7 76.2 40.6 228.0 107.3 196.8 85.9 43.2 92.6 178.5 50.6 103.1 55.9 87.4 181.8 83.1 130.6 120.5 145.2 133.8 80.7 43.0 43.2 138.1 516.5 76.2 55.7 87.4 331.4 80.3 45.8 142.8 77.9 147.1 73.1 50.5 159.0 38.5 33.8 26.9 86.6 127.5 48.8 82.3 87.6 57.5 77.9 39.4 51.2 31.0 30.8 30.7 35.8 48.4 31.7 17.6 24.9 33.1 34.8 30.4 38.1 35.9 74.8 27.8 26.1 29.7 30.1 27.7 33.0 41.4 31.5 43.4 33.9 37.9 27.4 27.3 25.6 27.9 21.5 39.6 59.9 127.3 120.5 56.9 10.7 44.7 36.6 22.0 74.4 81.0 77.3 20.9 238.5 61.4 184.2 39.2 180.5 0.5 41.9 26.3 31.3 44.3 58.3 15.9 115.8 111.7 39.6 57.6 58.2 46.9 48.6 37.9 36.7 88.7 21.9 15.2 76.9 59.0 51.2 34.0 2.0 43.5 67.1 48.0 14.0 112.7 38.5 61.8 6.6 1.9 179.4 124.1 50.8 17.7 78.6 155.6 34.6 71.1 16.2 39.5 25.3 36.7 0.5 2.8 102.0 68.9 196.6 40.2 35.4 125.3 156.6 CAPN10 ENSG00000142330 "Calpain 10" Q9HC96 2 240586734-240617705 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Diabetes mellitus" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Horizontal cells: 48.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004170, HPA056098" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 35: Non-specific - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 62: Horizontal cells - Visual perception" Nucleoplasm Cytosol "HPA004170: AB_1078381, HPA056098: AB_2683037" "unprognostic (1.05e-1)" "unprognostic (1.13e-2)" "unprognostic (9.29e-3)" "unprognostic (6.09e-2)" "unprognostic (5.44e-3)" "prognostic favorable (8.47e-5)" "prognostic unfavorable (4.78e-6)" "unprognostic (7.48e-3)" "unprognostic (7.94e-2)" "unprognostic (1.31e-2)" "prognostic favorable (7.94e-5)" "unprognostic (1.46e-1)" "unprognostic (1.11e-2)" "unprognostic (1.19e-1)" "unprognostic (6.88e-2)" "unprognostic (5.76e-2)" "unprognostic (5.58e-3)" 10.0 18.6 16.8 6.8 16.2 7.9 9.6 21.0 25.0 11.8 16.5 12.7 13.1 10.7 3.7 14.5 13.7 6.1 24.6 17.9 14.0 23.8 14.7 12.2 10.6 15.6 15.8 13.3 12.6 5.3 18.1 4.5 15.4 14.9 7.1 10.6 10.2 5.3 5.8 12.1 14.0 2.8 12.6 29.8 15.8 17.0 16.7 6.4 13.2 2.8 5.4 11.1 10.0 16.8 8.0 11.2 11.2 9.5 4.5 3.6 19.7 9.9 4.1 6.5 5.9 8.7 18.7 5.9 3.5 3.6 8.9 12.7 3.0 6.6 3.3 23.0 19.8 10.9 20.4 16.0 7.1 7.1 15.3 2.6 4.8 6.7 2.7 6.7 5.2 16.8 12.5 7.3 2.8 7.1 16.2 27.5 17.4 9.5 8.1 15.5 8.1 13.1 9.9 9.8 28.1 22.0 6.3 9.3 13.8 3.5 4.8 9.3 8.6 11.0 9.7 9.5 11.8 16.3 4.2 10.7 10.4 12.8 11.0 1.5 0.9 1.8 1.0 0.6 0.3 1.0 0.6 1.1 0.4 1.1 0.7 0.9 4.1 3.0 0.6 1.2 1.3 0.4 16.8 16.2 21.0 25.0 17.9 14.0 15.6 15.8 15.4 12.6 16.7 16.8 8.9 3.2 6.0 19.6 7.5 4.6 7.2 3.8 6.2 14.9 6.2 5.3 9.5 12.8 4.8 9.2 14.6 5.4 14.2 7.2 7.9 13.0 1.9 14.7 5.7 7.0 11.3 1.7 9.5 9.1 5.2 5.3 4.6 13.8 22.9 11.3 7.5 3.0 6.7 48.8 9.0 6.3 8.2 5.3 1.7 2.6 9.0 7.8 1.8 7.5 7.7 13.4 8.2 7.5 7.2 13.8 4.6 9.4 7.4 10.1 9.9 6.2 9.4 18.6 0.0 5.6 7.6 12.6 7.7 3.7 5.3 5.5 11.3 9.0 6.4 6.9 CAPN11 ENSG00000137225 "Calpain 11" Q9UMQ6 6 44158811-44184401 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 13 "testis: 30.3" "Cell type enhanced" "Detected in some" "Adipocytes: 14.0;Breast myoepithelial cells: 11.8;Early spermatids: 24.7;Late spermatids: 9.8;Spermatocytes: 50.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "NTERA-2: 2.2;TIME: 5.8" "Not detected" "Not detected" "Low region specificity" "Detected in many" "CAB018070, HPA030955" Enhanced NA NA "Cluster 83: Testis - Spermatogenesis" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 66: Spermatocytes - Spermatogenesis" "CAB018070: AB_2069481, HPA030955: AB_2673672" "unprognostic (2.20e-2)" "unprognostic (1.87e-1)" "unprognostic (1.64e-2)" "unprognostic (2.75e-1)" "unprognostic (6.22e-2)" "unprognostic (3.34e-2)" "unprognostic (3.99e-2)" "unprognostic (4.57e-2)" "unprognostic (1.29e-1)" "unprognostic (8.96e-2)" "unprognostic (1.01e-1)" "unprognostic (2.13e-1)" "unprognostic (3.62e-6)" "unprognostic (2.38e-2)" "unprognostic (3.51e-1)" "unprognostic (2.27e-2)" "unprognostic (8.89e-2)" 1.6 0.4 0.2 0.3 0.2 0.5 2.3 0.4 0.5 0.8 0.1 0.2 0.0 0.3 0.5 0.2 0.3 0.3 0.3 0.3 0.3 0.2 0.1 0.2 0.4 0.2 0.1 0.0 0.1 0.1 0.0 0.5 0.2 0.3 0.1 0.1 0.4 0.0 0.1 0.8 0.4 0.3 0.1 0.1 0.2 30.3 0.3 2.2 0.3 0.2 0.3 0.4 0.5 0.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.8 0.0 0.2 0.2 0.0 0.0 0.0 0.1 2.2 0.0 0.0 0.3 0.1 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.1 5.8 0.2 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.2 0.2 0.4 0.5 0.3 0.3 0.2 0.1 0.2 0.1 0.3 0.5 14.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.5 11.8 0.5 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 24.7 0.0 0.0 3.9 0.0 2.7 0.5 0.0 0.0 0.7 0.0 0.2 0.0 0.1 1.1 0.0 1.3 0.0 0.3 0.1 0.0 0.3 0.3 9.8 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.7 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.2 50.0 0.9 0.1 0.0 0.0 0.1 0.1 0.1 0.1 CAPN12 ENSG00000182472 "Calpain 12" Q6ZSI9 19 38730187-38769904 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "gallbladder: 22.8;liver: 24.8" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 41.4;Cholangiocytes: 41.5;NK-cells: 39.1" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Group enriched" "Detected in many" 9 "basophil: 59.3;NK-cell: 25.5" "Group enriched" "Detected in many" 9 "granulocytes: 59.3;NK-cells: 25.5" "Cell line enriched" "Detected in some" 14 "HMC-1: 35.1" "Not detected" "Not detected" "Region enhanced" "Detected in single" "hippocampal formation: 3.0" HPA053322 Approved "Nucleoplasm,Focal adhesion sites" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 3: HMC-1 - Innate immune response" "Cluster 63: NK-cells & T-cells - Immune response" "Focal adhesion sites" Nucleoplasm "HPA053322: AB_2682111" "unprognostic (1.81e-1)" "unprognostic (4.48e-2)" "unprognostic (1.04e-2)" "unprognostic (1.08e-1)" "unprognostic (1.95e-2)" "unprognostic (2.81e-2)" "unprognostic (1.02e-1)" "unprognostic (6.01e-3)" "unprognostic (7.20e-2)" "unprognostic (2.45e-2)" "unprognostic (1.29e-1)" "unprognostic (4.01e-2)" "prognostic unfavorable (5.90e-6)" "unprognostic (7.04e-2)" "unprognostic (4.01e-2)" "unprognostic (3.00e-1)" "unprognostic (4.59e-2)" 0.5 0.2 0.4 1.3 0.4 0.5 0.6 0.3 0.7 5.3 0.3 1.1 2.6 1.1 0.7 1.0 2.9 22.8 1.1 0.3 0.7 3.5 24.8 2.5 2.2 0.5 0.4 0.3 1.9 0.5 0.3 0.2 0.7 0.4 1.0 0.0 5.3 1.2 0.4 4.0 1.0 0.8 0.3 1.9 2.0 0.5 0.7 1.3 0.3 0.0 2.8 0.5 0.9 0.4 0.2 1.4 0.0 0.0 0.2 0.1 2.0 0.0 0.0 0.0 0.1 2.4 0.1 0.6 0.0 0.0 0.3 1.0 0.0 0.6 0.0 0.1 0.0 0.2 0.7 0.7 0.0 0.0 35.1 0.6 2.0 0.2 0.0 0.0 0.0 0.0 0.4 0.4 0.2 0.2 0.0 0.0 0.4 0.8 0.0 0.0 0.0 0.1 1.4 0.0 0.1 0.0 0.1 0.3 0.0 0.3 0.1 1.1 0.0 0.0 0.0 0.0 0.4 0.7 0.6 0.0 0.1 0.0 0.5 59.3 0.1 3.6 4.4 0.0 4.4 2.6 1.3 2.4 0.1 3.8 0.0 1.1 0.7 25.5 0.0 0.0 1.0 1.2 0.4 0.4 0.3 0.7 0.3 0.7 0.5 0.4 0.7 0.3 0.7 0.4 2.5 12.8 41.4 0.7 14.8 9.4 9.2 16.5 4.0 1.6 3.3 4.6 0.9 41.5 8.5 5.5 0.0 1.7 17.7 4.3 0.0 11.6 0.8 7.8 2.8 2.6 3.6 1.3 0.5 7.2 9.4 1.1 8.6 21.2 5.1 0.9 2.5 16.1 1.0 0.0 0.2 21.4 10.2 1.3 3.3 0.6 0.6 1.4 3.6 1.0 1.0 1.4 39.1 0.0 0.3 5.4 6.0 0.4 9.8 5.4 9.7 21.7 10.0 0.6 0.0 2.3 3.0 0.3 2.4 3.4 9.5 2.9 19.1 2.2 15.7 4.8 CAPN13 FLJ23523 ENSG00000162949 "Calpain 13" Q6MZZ7 2 30722771-30820542 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 29.2;stomach 1: 28.5" "Cell type enhanced" "Detected in many" "Club cells: 76.6;Gastric mucus-secreting cells: 50.0;Proximal enterocytes: 35.2;Undifferentiated cells: 18.1;Urothelial cells: 19.4" "Cancer enhanced" "Detected in many" "endometrial cancer: 11.3" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "RT4: 9.3;SK-BR-3: 21.9" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA029496, HPA029497, HPA030034" Uncertain Approved Nucleoplasm NA NA "Cluster 9: Intestine - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Nucleoplasm "HPA029496: AB_2673072, HPA029497: AB_2673073, HPA030034: AB_2673281" "unprognostic (7.42e-2)" "unprognostic (1.19e-1)" "unprognostic (7.01e-3)" "unprognostic (1.96e-1)" "unprognostic (8.56e-2)" "unprognostic (1.51e-1)" "unprognostic (1.68e-1)" "unprognostic (1.32e-3)" "unprognostic (2.17e-1)" "unprognostic (2.66e-2)" "unprognostic (1.11e-1)" "unprognostic (2.49e-1)" "unprognostic (1.96e-2)" "unprognostic (3.64e-1)" "unprognostic (3.32e-2)" "unprognostic (5.03e-2)" "unprognostic (4.28e-3)" 0.0 0.0 0.8 0.0 1.4 0.0 7.2 0.9 1.3 9.7 1.0 11.4 20.8 0.2 0.3 0.9 1.1 2.8 0.0 0.7 0.8 2.5 0.2 7.2 0.0 1.1 1.3 0.0 3.6 0.4 0.2 0.0 1.0 3.8 24.6 0.0 1.2 0.1 0.0 0.2 29.2 0.2 1.0 0.1 28.5 0.1 1.1 0.0 0.0 0.0 0.6 4.1 0.5 2.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.6 9.3 0.1 0.4 0.0 21.9 0.0 0.7 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 1.4 0.9 1.3 0.7 0.8 1.1 1.3 1.0 1.0 1.1 2.3 0.0 6.4 3.1 0.3 0.0 0.0 10.2 3.5 4.0 0.0 4.2 1.8 1.3 0.0 76.6 1.8 0.0 0.0 0.0 16.9 0.0 1.3 0.8 2.0 0.0 0.1 15.0 0.0 0.3 5.3 0.0 0.6 50.0 0.7 1.3 0.0 0.0 0.0 0.0 0.0 1.5 12.0 6.1 0.0 0.0 0.4 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 8.4 1.9 6.2 0.0 0.0 2.7 35.2 0.2 12.4 0.0 0.0 0.0 6.1 0.0 0.1 1.4 0.0 0.0 0.1 0.0 18.1 19.4 CAPN14 ENSG00000214711 "Calpain 14" A8MX76 2 31173056-31233858 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 17 "esophagus: 144.1" "Cell type enhanced" "Detected in some" "Excitatory neurons: 3.2;Inhibitory neurons: 4.2;Squamous epithelial cells: 8.2;Urothelial cells: 15.5" "Cancer enhanced" "Detected in some" "cervical cancer: 2.9;head and neck cancer: 2.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "RT4: 1.1;U-266/70: 3.4" "Not detected" "Not detected" NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 29: U-266 - Adaptive immune response" "Cluster 22: Epithelial cell types - Mixed function" "unprognostic (5.81e-3)" "unprognostic (1.20e-1)" "unprognostic (4.57e-2)" "unprognostic (1.88e-2)" "unprognostic (3.85e-2)" "unprognostic (3.30e-1)" "unprognostic (3.61e-2)" "unprognostic (4.67e-2)" "unprognostic (1.71e-1)" "unprognostic (3.14e-1)" "unprognostic (3.77e-1)" "unprognostic (1.60e-1)" "unprognostic (3.71e-4)" "unprognostic (8.42e-2)" "unprognostic (6.84e-2)" "unprognostic (1.91e-1)" "unprognostic (4.47e-4)" 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 144.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.9 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 8.2 0.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.1 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 1.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.9 0.0 0.5 0.1 0.6 0.8 0.1 0.0 1.7 0.0 0.7 0.0 0.0 0.1 0.1 0.4 0.0 0.0 0.6 0.8 0.1 0.2 0.0 0.0 3.2 0.0 0.1 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.1 1.7 4.2 0.0 0.0 0.3 0.0 0.8 0.0 0.0 0.0 0.0 0.1 0.0 1.0 0.5 0.5 0.0 2.2 0.0 0.0 0.7 0.0 0.0 0.0 1.4 0.0 0.0 0.1 0.0 0.2 8.2 0.0 1.4 0.1 0.0 0.1 15.5 CAPN15 SOLH ENSG00000103326 "Calpain 15" O75808 16 527712-554636 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 54.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Group enriched" "Detected in many" 4 "basophil: 4.7;neutrophil: 16.2" "Lineage enriched" "Detected in many" 7 "granulocytes: 16.2" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011960 Uncertain Approved Nucleoplasm NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 18: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "HPA011960: AB_10610556" "unprognostic (4.11e-2)" "unprognostic (1.63e-1)" "unprognostic (1.14e-1)" "unprognostic (2.66e-1)" "unprognostic (7.18e-2)" "unprognostic (1.12e-2)" "unprognostic (1.54e-3)" "unprognostic (8.31e-3)" "unprognostic (1.32e-1)" "unprognostic (1.24e-1)" "unprognostic (1.86e-1)" "unprognostic (4.02e-2)" "unprognostic (2.53e-3)" "unprognostic (2.54e-3)" "unprognostic (5.91e-2)" "unprognostic (1.83e-1)" "unprognostic (9.23e-3)" 13.0 12.0 3.6 7.2 2.5 8.1 10.8 11.6 6.2 12.2 0.2 20.2 16.3 13.4 0.4 18.5 13.2 1.6 11.2 3.2 0.2 18.4 17.2 15.3 5.1 4.1 1.0 13.2 24.8 2.2 15.2 2.6 1.4 12.3 2.3 1.1 12.6 2.8 14.9 22.3 22.7 1.2 0.2 21.2 16.5 18.7 2.1 2.8 11.7 0.9 2.5 12.5 12.8 0.8 16.8 21.5 3.0 9.3 1.7 3.4 46.2 17.5 4.6 4.9 3.3 28.2 12.1 24.0 16.3 3.2 5.0 21.9 2.0 6.9 1.8 25.2 37.1 20.2 25.7 17.6 7.3 23.8 27.3 3.9 4.0 4.9 2.2 2.9 5.3 14.7 37.6 7.1 1.6 25.9 27.1 26.0 26.7 8.6 20.2 46.5 8.7 24.2 3.3 11.0 19.6 17.8 11.7 16.2 10.2 1.8 13.3 24.7 26.2 15.3 21.4 15.7 22.0 18.2 11.0 21.3 6.7 13.8 9.7 4.7 1.3 0.8 0.3 0.8 0.1 0.4 0.1 0.4 0.3 2.3 0.1 0.2 16.2 1.1 1.3 0.5 0.2 0.3 3.6 2.5 11.6 6.2 3.2 0.2 4.1 1.0 1.4 0.2 2.1 0.8 7.6 3.2 8.4 10.1 5.9 8.9 5.7 6.2 3.4 12.1 7.6 6.6 3.1 8.6 5.6 7.3 16.7 3.7 22.3 54.3 1.9 6.2 16.5 6.1 8.9 8.7 4.2 1.7 10.6 15.7 4.4 6.9 20.4 13.3 7.0 10.8 8.9 16.5 6.8 20.2 11.3 26.9 8.2 12.0 6.8 6.2 7.5 8.2 1.8 7.5 6.5 9.1 23.7 10.6 7.8 14.3 37.1 4.5 5.8 13.4 33.1 5.7 4.6 11.2 0.0 10.2 5.2 5.3 7.4 5.8 8.0 2.5 9.2 9.6 25.9 11.6 CAPN2 "CANPL2, CANPml, mCANP" ENSG00000162909 "Calpain 2" P17655 1 223701593-223776018 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "TIME: 858.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024470 Approved Approved Supported Cytosol NA NA 2800000 "Cluster 39: Non-specific - mRNA processing" "Cluster 46: Fibroblasts - ECM organization" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 16: Pancreatic endocrine cells - Mixed function" Cytosol "HPA024470: AB_1845925" "unprognostic (2.77e-2)" "unprognostic (1.27e-3)" "unprognostic (2.03e-1)" "unprognostic (3.39e-2)" "unprognostic (2.12e-1)" "unprognostic (3.32e-2)" "unprognostic (1.59e-1)" "unprognostic (1.10e-1)" "unprognostic (2.85e-1)" "unprognostic (1.96e-1)" "prognostic unfavorable (2.50e-4)" "unprognostic (1.21e-1)" "prognostic favorable (2.19e-4)" "unprognostic (1.61e-1)" "unprognostic (2.63e-1)" "unprognostic (2.62e-1)" "prognostic unfavorable (6.21e-4)" 118.8 93.9 40.2 64.9 50.0 40.9 92.4 45.3 39.6 110.4 29.4 140.1 46.2 67.7 58.0 134.3 120.5 119.7 71.8 36.9 42.7 115.2 31.2 182.5 35.5 51.9 46.1 83.2 55.1 136.3 28.0 68.3 46.6 47.5 131.4 19.2 151.2 91.2 82.2 41.6 58.5 87.3 43.4 42.5 130.4 26.3 49.1 27.0 80.9 81.6 54.3 85.6 89.3 49.3 419.9 263.7 79.2 54.9 257.6 356.6 79.4 383.9 541.3 267.2 151.1 209.2 323.6 0.4 125.0 417.1 209.1 255.1 86.3 593.1 243.4 109.8 95.2 7.8 124.9 25.6 232.3 21.5 13.9 193.3 187.3 416.6 217.8 472.3 537.1 0.1 123.2 106.8 789.3 8.6 1.0 19.4 45.5 49.7 346.3 35.4 262.4 7.3 454.9 24.3 17.7 94.7 198.1 524.2 122.8 189.7 80.9 98.7 858.1 252.7 212.0 220.6 498.4 32.5 66.8 1.4 625.3 46.2 284.7 7.9 118.6 7.2 106.8 77.9 89.8 34.4 72.6 103.2 163.9 16.6 22.9 62.2 6.1 24.5 73.7 7.4 81.7 136.6 40.2 50.0 45.3 39.6 36.9 42.7 51.9 46.1 46.6 43.4 49.1 49.3 240.0 394.2 134.9 82.9 42.3 47.3 136.6 197.5 38.7 12.0 35.7 32.8 38.4 115.8 264.4 53.3 33.3 24.4 72.4 356.0 181.9 271.4 94.5 70.0 52.7 125.3 24.6 6.9 13.3 195.9 92.0 105.0 103.5 93.3 27.8 47.8 35.7 9.7 38.9 13.5 23.1 104.4 242.1 50.0 239.3 232.8 77.3 86.4 112.1 22.5 66.0 22.6 78.2 48.7 21.6 373.0 191.5 68.8 83.3 237.7 104.1 23.6 288.8 18.0 39.5 85.0 107.9 3.4 3.3 67.5 27.6 8.2 83.5 63.5 98.2 268.2 CAPN3 "CANP3, LGMD2, LGMD2A, nCL-1, p94" ENSG00000092529 "Calpain 3" P20807 15 42359498-42412949 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Disease variant, Limb-girdle muscular dystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 279.2;skeletal muscle: 905.9;tongue: 377.4" "Group enriched" "Detected in many" 5 "Early spermatids: 512.5;Late spermatids: 183.6;Melanocytes: 482.0;Oligodendrocytes: 220.2" "Cancer enriched" "Detected in some" 10 "melanoma: 9.1" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enriched" "Detected in many" 27 "SK-MEL-30: 238.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040052 Enhanced NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 80: Striated muscle - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 23: Spermatids - Flagellum & Golgi organization" "HPA040052: AB_2676821" "unprognostic (1.06e-2)" "unprognostic (1.31e-1)" "unprognostic (4.00e-2)" "unprognostic (8.71e-2)" "unprognostic (1.53e-1)" "unprognostic (1.72e-2)" "unprognostic (2.11e-4)" "unprognostic (3.12e-3)" "unprognostic (2.82e-1)" "unprognostic (2.47e-1)" "unprognostic (2.37e-3)" "unprognostic (3.26e-2)" "unprognostic (3.91e-4)" "unprognostic (5.56e-3)" "unprognostic (2.43e-1)" "unprognostic (8.93e-3)" "unprognostic (1.38e-1)" 13.5 8.8 136.1 4.0 206.6 47.6 14.1 194.2 243.3 18.8 113.0 13.3 3.1 11.2 163.7 14.5 13.7 4.5 16.1 142.9 159.9 93.6 36.9 21.5 7.0 212.0 194.9 15.7 8.7 2.4 11.3 3.0 212.1 16.0 5.3 7.5 18.6 5.2 905.9 54.9 14.0 4.7 155.2 19.1 8.9 30.8 187.8 3.4 10.7 377.4 5.1 11.7 15.5 279.2 0.5 0.3 0.6 1.1 8.8 6.1 0.6 2.6 1.9 0.5 0.8 1.2 0.5 0.2 0.9 1.6 0.4 3.7 0.4 3.5 0.3 0.9 0.8 0.8 0.8 4.1 0.6 1.0 1.5 4.7 3.7 0.8 0.7 1.5 0.1 0.7 0.2 1.8 0.7 0.1 0.2 1.2 0.4 0.2 0.9 1.1 0.4 1.9 1.9 1.3 0.4 0.1 0.2 0.5 238.0 1.0 0.0 5.4 0.9 0.3 0.4 2.6 0.7 1.5 2.1 0.2 0.4 2.4 1.8 0.5 1.0 0.1 0.7 0.2 0.8 0.3 0.1 0.3 0.5 0.5 0.1 0.9 0.9 0.6 0.1 0.5 0.4 0.6 136.1 206.6 194.2 243.3 142.9 159.9 212.0 194.9 212.1 155.2 187.8 279.2 0.5 12.8 34.5 16.0 2.9 20.1 0.8 2.2 3.4 2.2 0.4 0.3 0.4 1.5 4.4 1.8 2.1 0.7 1.4 2.0 1.9 0.1 512.5 0.5 0.6 2.2 0.0 0.0 4.0 0.0 0.6 1.6 3.6 0.7 1.3 0.4 2.2 8.7 32.7 0.0 5.2 1.8 2.0 4.4 11.6 183.6 5.3 2.9 482.0 13.1 2.5 3.7 2.1 4.5 220.2 0.0 5.4 3.4 0.6 0.9 2.4 59.5 2.6 3.9 0.0 13.8 1.6 15.9 4.7 1.6 8.5 3.3 1.8 1.2 2.3 0.8 CAPN5 "ADNIV, HTRA3, nCL-3, VRNI" ENSG00000149260 "Calpain 5" O15484 11 77066961-77126155 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 60.7" "Cell type enhanced" "Detected in many" "Distal enterocytes: 170.3;Gastric mucus-secreting cells: 80.0;Intestinal goblet cells: 89.8;Paneth cells: 72.6;Proximal enterocytes: 75.6;Undifferentiated cells: 69.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "gdT-cell: 1.3" "Lineage enriched" "Detected in single" 4 "T-cells: 1.3" "Cell line enhanced" "Detected in many" "OE19: 106.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033237, HPA072319" Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm Cytosol "CAB033237: AB_2069673, HPA072319: AB_2686512" "unprognostic (6.81e-3)" "unprognostic (1.31e-1)" "unprognostic (3.36e-2)" "prognostic unfavorable (2.16e-6)" "unprognostic (3.47e-3)" "unprognostic (1.34e-1)" "unprognostic (1.13e-1)" "unprognostic (5.30e-2)" "unprognostic (2.52e-1)" "unprognostic (2.21e-2)" "unprognostic (5.35e-3)" "unprognostic (4.64e-1)" "unprognostic (3.17e-3)" "unprognostic (8.58e-3)" "unprognostic (3.25e-1)" "unprognostic (2.31e-2)" "unprognostic (2.30e-3)" 6.7 12.2 8.5 10.9 7.9 2.7 4.9 6.4 8.6 13.5 3.5 60.5 60.7 10.0 5.7 31.6 10.8 36.3 7.2 8.5 8.7 15.1 52.1 4.8 1.9 11.7 8.2 13.2 5.6 1.0 5.1 2.8 12.5 16.0 49.9 3.8 7.7 8.9 1.6 3.1 52.4 11.3 9.9 3.5 47.9 21.5 7.9 2.8 4.7 1.7 2.7 15.4 10.5 8.1 0.8 12.5 8.6 7.8 32.0 30.4 0.7 11.8 22.9 13.4 10.0 6.9 3.6 0.4 7.7 24.5 14.4 0.5 3.8 1.0 6.4 0.5 0.8 2.1 0.5 0.9 7.9 0.2 0.4 16.1 1.4 22.6 5.2 18.8 14.4 5.1 0.2 0.0 26.9 19.9 1.8 0.3 6.6 106.6 9.3 2.0 27.0 0.4 4.6 16.4 0.5 13.5 1.0 2.7 5.9 5.7 1.7 0.1 23.9 25.4 12.3 34.8 1.3 0.8 1.7 0.1 13.1 0.3 5.7 0.0 0.2 0.0 1.3 0.3 0.1 0.0 0.1 0.5 0.2 0.0 0.6 0.8 0.0 0.0 0.0 0.1 0.0 0.7 8.5 7.9 6.4 8.6 8.5 8.7 11.7 8.2 12.5 9.9 7.9 8.1 1.6 0.0 0.5 4.2 1.0 1.7 0.3 2.2 0.0 3.1 0.5 1.8 1.7 24.3 10.3 23.9 0.0 0.1 3.4 170.3 1.9 10.3 1.1 1.9 5.9 2.4 22.3 5.7 4.6 32.7 0.4 7.6 80.0 3.5 0.0 10.2 2.9 40.4 0.9 1.7 6.7 89.8 10.2 1.6 1.8 1.3 12.5 1.2 7.2 1.0 0.3 5.8 5.2 11.6 0.7 22.4 72.6 4.5 0.9 2.0 75.6 9.9 11.1 2.1 0.0 8.3 4.1 0.5 2.3 2.5 0.9 0.0 1.5 5.3 69.2 2.4 CAPN6 "CalpM, CANPX, CAPNX" ENSG00000077274 "Calpain 6" Q9Y6Q1 X 111245099-111270483 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "epididymis: 212.7;placenta: 83.1;seminal vesicle: 72.4" "Group enriched" "Detected in some" 4 "Extravillous trophoblasts: 198.5;Syncytiotrophoblasts: 140.5" "Cancer enhanced" "Detected in many" "endometrial cancer: 25.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "HDLM-2: 10.8;NTERA-2: 16.3;SuSa: 14.3" "Low region specificity" "Detected in many" "Region enhanced" "Detected in many" "spinal cord: 9.6" HPA040259 Approved "Nucleoplasm,Centriolar satellite,Cytosol" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 30: Epididymis - Antimicrobial activity" "Cluster 5: NTERA-2 - Transcription" "Cluster 38: Extravillous trophoblasts - Unknown function" "Centriolar satellite" "Nucleoplasm, Cytosol" "HPA040259: " "unprognostic (1.27e-3)" "unprognostic (2.04e-1)" "unprognostic (2.69e-2)" "unprognostic (5.77e-3)" "unprognostic (2.07e-1)" "unprognostic (9.93e-2)" "unprognostic (8.39e-3)" "unprognostic (1.06e-1)" "unprognostic (2.08e-1)" "unprognostic (9.45e-3)" "unprognostic (5.12e-1)" "unprognostic (6.25e-2)" "unprognostic (7.67e-2)" "unprognostic (6.50e-2)" "unprognostic (5.02e-3)" "unprognostic (2.66e-1)" "unprognostic (6.30e-2)" 2.1 0.0 0.0 7.2 0.0 0.0 12.7 0.0 0.0 11.9 0.0 5.6 1.8 22.5 212.7 2.3 3.2 8.4 0.3 0.0 0.0 11.5 0.3 0.5 2.8 0.0 0.0 2.6 7.5 0.1 0.2 83.1 0.0 10.6 8.6 0.0 14.1 72.4 3.0 1.0 1.7 8.2 0.0 1.7 12.9 2.0 0.0 1.8 1.5 9.0 4.7 3.8 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 10.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 16.3 0.0 0.0 0.0 0.0 0.1 1.4 0.0 0.1 0.3 0.4 0.3 0.0 14.3 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 1.1 0.0 1.2 0.0 0.6 2.0 0.3 7.2 0.0 7.3 0.0 39.9 0.1 0.1 3.9 8.3 0.0 18.0 4.3 0.4 0.0 0.0 0.0 0.7 198.5 12.9 6.6 40.1 0.0 0.0 0.0 0.0 7.6 0.0 0.1 1.2 0.0 0.0 0.3 0.5 0.9 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 22.2 0.1 0.4 0.0 0.2 0.0 0.0 0.0 1.0 0.5 0.1 0.1 0.9 0.0 140.5 0.3 0.9 0.5 0.3 CAPN7 PalBH ENSG00000131375 "Calpain 7" Q9Y6W3 3 15206152-15252916 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004745, HPA046617" Uncertain Approved Centrosome,Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 28: BEWO - Transcription regulation" "Cluster 46: Photoreceptor cells - Phototransduction" Cytosol Centrosome "HPA004745: , HPA046617: AB_2679721" "unprognostic (2.70e-2)" "unprognostic (2.79e-1)" "prognostic favorable (4.85e-5)" "unprognostic (1.85e-1)" "unprognostic (1.69e-2)" "unprognostic (1.41e-2)" "unprognostic (2.22e-3)" "unprognostic (2.72e-1)" "unprognostic (1.42e-1)" "unprognostic (2.76e-1)" "unprognostic (1.39e-1)" "unprognostic (5.29e-2)" "unprognostic (1.12e-3)" "unprognostic (3.24e-2)" "unprognostic (7.84e-2)" "unprognostic (5.66e-2)" "unprognostic (1.05e-2)" 13.9 11.9 4.6 11.6 5.9 13.2 16.6 12.5 5.4 16.9 9.3 12.1 12.9 16.1 14.9 11.4 14.4 11.1 11.6 4.1 8.1 15.2 19.1 12.1 14.3 5.9 5.7 19.8 15.3 20.1 9.2 12.9 5.5 14.1 12.2 28.5 13.9 12.7 25.3 11.6 13.6 13.8 6.0 11.4 14.0 12.1 6.8 16.9 23.5 16.5 15.7 10.2 9.8 9.7 14.3 18.5 15.1 9.5 26.0 20.1 51.4 18.1 20.8 22.1 16.7 13.3 10.0 24.6 12.3 20.7 13.6 9.7 22.5 23.3 19.0 23.7 17.5 30.8 24.8 17.7 19.3 25.1 15.0 13.9 33.2 28.7 14.1 20.9 15.9 23.3 30.3 25.1 21.6 20.8 17.9 10.5 14.5 20.7 17.7 10.2 25.1 17.1 16.4 25.8 12.2 15.8 29.5 15.7 20.8 19.2 27.9 25.8 14.4 19.8 14.9 25.9 21.4 17.2 37.1 12.4 18.1 18.0 17.5 4.6 3.0 5.1 3.3 2.5 5.3 3.5 3.6 2.8 2.9 3.1 4.9 4.6 1.8 3.6 4.4 2.4 3.0 3.0 4.6 5.9 12.5 5.4 4.1 8.1 5.9 5.7 5.5 6.0 6.8 9.7 15.8 12.8 23.6 44.1 35.0 21.4 13.5 10.6 47.3 42.7 20.3 16.0 33.2 8.6 20.6 1.8 56.3 21.2 21.7 11.2 9.8 12.6 15.5 32.2 31.5 19.0 20.9 14.9 60.2 16.9 12.6 27.6 30.1 29.9 15.8 28.9 14.6 20.8 12.2 55.5 65.8 11.3 4.1 11.9 23.0 14.8 24.8 20.9 21.4 49.6 18.4 31.2 10.3 73.9 86.0 13.0 6.9 26.4 52.8 20.0 16.7 15.2 34.9 98.1 39.5 31.5 24.8 26.8 17.8 29.7 23.2 26.1 34.2 21.1 11.8 14.3 CAPN8 nCL-2 ENSG00000203697 "Calpain 8" A6NHC0 1 223538007-223665723 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 9 "stomach 1: 291.1" "Cell type enriched" "Detected in many" 6 "Gastric mucus-secreting cells: 910.8" "Cancer enhanced" "Detected in many" "pancreatic cancer: 28.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 12 "OE19: 125.9;RT4: 76.8" "Not detected" "Not detected" "Not detected" "Not detected" HPA073939 Approved "Nucleoplasm,Nuclear membrane,Vesicles" No NA "Cluster 4: Stomach - Digestion" "Cluster 21: OE19 - Mitochondria" "Cluster 16: Pancreatic endocrine cells - Mixed function" "Nucleoplasm, Nuclear membrane, Vesicles" "HPA073939: AB_2686646" "unprognostic (4.87e-3)" "unprognostic (2.58e-1)" "unprognostic (1.89e-1)" "unprognostic (2.06e-2)" "unprognostic (1.32e-2)" "unprognostic (1.49e-1)" "unprognostic (7.97e-3)" "unprognostic (1.19e-1)" "unprognostic (1.26e-1)" "unprognostic (8.08e-2)" "unprognostic (2.72e-3)" "unprognostic (3.55e-1)" "unprognostic (4.12e-6)" "unprognostic (6.95e-2)" "unprognostic (5.59e-2)" "unprognostic (3.83e-2)" "unprognostic (5.44e-3)" 0.3 0.2 4.7 6.3 1.0 0.1 14.9 0.1 1.7 1.1 2.3 23.6 8.0 0.1 11.1 0.6 1.3 14.3 0.0 2.3 3.6 1.7 0.3 21.3 0.1 2.7 1.5 0.2 2.9 0.0 0.1 0.3 1.1 2.9 33.0 0.3 8.5 1.4 0.8 2.3 4.6 1.1 2.0 0.3 291.1 0.6 1.8 0.0 0.2 0.0 0.3 12.3 0.7 2.5 1.5 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.1 0.8 0.0 4.6 0.0 0.1 0.0 0.2 8.3 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.3 0.0 0.4 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 1.0 0.2 0.0 0.2 125.9 3.8 0.1 0.0 0.0 1.3 76.8 1.2 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.2 4.7 1.0 0.1 1.7 2.3 3.6 2.7 1.5 1.1 2.0 1.8 2.5 0.4 28.9 131.7 1.6 1.8 0.1 6.5 1.9 0.0 0.0 19.9 7.9 2.6 10.0 55.9 25.8 0.0 0.2 0.2 90.9 0.0 3.8 2.3 2.0 0.3 0.7 3.0 0.0 0.6 21.6 0.0 0.3 910.8 2.1 10.8 5.2 0.0 0.3 0.6 0.0 0.1 61.9 4.1 0.0 0.8 6.7 1.8 1.8 0.0 0.0 0.0 0.0 1.0 0.0 0.1 36.1 42.6 3.4 3.5 4.0 2.1 1.5 15.0 0.0 0.0 0.3 0.8 0.4 1.0 0.0 0.0 0.1 1.4 2.9 21.2 31.2 CAPN9 "GC36, nCL-4" ENSG00000135773 "Calpain 9" O14815 1 230747384-230802003 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 22.2;stomach 1: 60.3" "Group enriched" "Detected in some" 5 "Alveolar cells type 1: 25.6;Gastric mucus-secreting cells: 93.8;Intestinal goblet cells: 71.8" "Cancer enhanced" "Detected in many" "pancreatic cancer: 7.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "OE19: 10.7;SCLC-21H: 14.7" "Not detected" "Not detected" "Not detected" "Not detected" "HPA020398, CAB033483, HPA062050" Enhanced Approved "Golgi apparatus,Vesicles" NA NA "Cluster 4: Stomach - Digestion" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 27: Mucus-secreting cells - Mucin production" Vesicles "Golgi apparatus" "CAB033483: AB_1119945, HPA020398: AB_2670429, HPA062050: " "unprognostic (2.64e-1)" "unprognostic (1.20e-1)" "unprognostic (2.60e-2)" "unprognostic (1.09e-1)" "unprognostic (2.20e-1)" "unprognostic (2.49e-2)" "unprognostic (3.36e-2)" "unprognostic (2.30e-2)" "unprognostic (4.61e-2)" "unprognostic (3.44e-2)" "unprognostic (9.10e-2)" "unprognostic (1.60e-1)" "unprognostic (5.97e-5)" "unprognostic (1.51e-1)" "unprognostic (2.08e-1)" "unprognostic (4.60e-2)" "unprognostic (2.16e-1)" 0.0 0.6 1.4 0.9 2.2 0.0 0.4 1.3 1.2 0.4 0.0 13.7 6.6 0.2 0.5 0.2 2.5 0.6 0.4 1.1 1.4 0.0 0.0 7.5 0.0 2.1 1.7 0.6 0.2 1.0 0.0 0.0 1.8 0.6 22.2 5.0 11.3 0.1 0.2 0.1 11.7 0.5 1.9 0.0 60.3 0.2 1.7 0.1 0.1 0.1 0.0 2.0 0.1 3.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.6 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.3 0.1 0.0 0.5 10.7 0.0 0.4 0.0 0.0 0.0 0.1 14.7 0.0 0.0 0.4 0.0 0.1 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 2.2 1.3 1.2 1.1 1.4 2.1 1.7 1.8 1.9 1.7 3.4 0.0 25.6 3.0 0.3 0.1 0.0 0.6 0.7 0.0 0.0 0.6 0.3 6.0 0.0 3.2 0.0 0.0 0.1 0.0 4.1 0.0 0.2 5.2 1.5 0.1 0.1 3.0 0.0 0.4 0.2 0.0 0.4 93.8 0.5 2.5 0.1 0.0 0.0 0.1 0.0 0.4 71.8 0.0 0.0 0.0 11.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 3.6 1.7 5.0 0.0 0.2 0.5 3.3 0.1 8.2 1.7 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.1 0.0 2.1 1.5 CASP1 "ICE, IL1BC" ENSG00000137752 "Caspase 1" P29466 11 105025443-105035250 "Cancer-related genes, Enzymes, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 126.0;lymphoid tissue: 91.0" "Cell type enhanced" "Detected in many" "Kupffer cells: 125.3;Langerhans cells: 120.7;Macrophages: 136.6;monocytes: 185.6;Proximal enterocytes: 116.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+: 112.7;HBEC3-KT: 53.8;HHSteC: 58.2;U-937: 136.2" "Region enhanced" "Detected in all" "olfactory bulb: 18.4" "Low region specificity" "Detected in all" "CAB002685, HPA003056" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 14: B-cells - Humoral immune response" "Cluster 32: U-937 - Innate immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Cytosol Nucleoplasm "CAB002685: , HPA003056: AB_1846037" "unprognostic (1.21e-3)" "unprognostic (3.02e-1)" "unprognostic (9.47e-3)" "unprognostic (1.43e-1)" "unprognostic (1.47e-1)" "unprognostic (1.21e-1)" "unprognostic (5.24e-2)" "unprognostic (1.97e-1)" "unprognostic (1.66e-1)" "unprognostic (6.67e-2)" "unprognostic (2.75e-2)" "unprognostic (1.35e-1)" "prognostic unfavorable (3.11e-4)" "unprognostic (9.03e-2)" "unprognostic (2.30e-2)" "unprognostic (3.18e-1)" "unprognostic (5.19e-2)" 20.4 10.5 8.7 59.1 8.8 36.3 21.9 9.3 14.6 11.9 9.8 47.7 124.6 8.7 12.0 27.2 12.3 27.4 12.2 8.5 9.6 13.3 21.6 48.3 52.1 11.2 9.4 11.7 6.4 2.7 5.0 30.0 11.1 13.0 49.7 1.1 20.8 12.5 6.2 30.9 126.0 20.8 10.7 91.0 22.5 2.4 10.7 23.2 7.8 7.3 35.5 35.7 19.4 11.9 1.3 0.3 0.0 5.3 5.8 12.1 1.0 5.7 112.7 14.0 38.5 0.2 0.7 18.7 2.3 6.6 25.7 8.1 0.0 53.8 3.3 12.3 0.0 0.9 0.7 1.3 58.2 22.1 0.2 20.9 37.4 11.4 30.3 36.2 6.1 0.3 0.2 0.0 3.4 0.0 0.6 30.7 0.0 0.1 0.3 18.1 0.4 14.9 0.3 8.9 0.4 0.4 16.9 1.1 26.2 0.1 1.2 50.1 7.2 12.8 0.6 1.2 1.6 0.1 5.4 0.1 8.1 136.2 2.7 83.8 246.1 134.9 132.9 359.9 178.5 40.2 92.7 115.8 220.2 35.5 50.2 82.7 220.0 63.0 383.0 7.7 129.0 213.3 8.7 8.8 9.3 14.6 8.5 9.6 11.2 9.4 11.1 10.7 10.7 11.9 26.3 19.2 30.0 0.0 27.2 26.0 42.5 91.5 14.2 0.1 5.8 23.0 2.9 8.6 37.7 11.0 0.0 2.1 34.1 33.1 1.9 23.3 0.2 5.8 2.5 24.0 6.0 10.3 0.2 12.9 1.3 17.8 11.7 3.4 15.8 0.2 22.9 3.1 96.5 0.0 0.0 50.6 14.2 125.3 120.7 1.3 3.4 136.6 5.4 12.2 185.6 0.1 64.9 0.0 0.1 5.3 73.4 3.4 20.0 8.7 116.0 2.2 28.4 0.2 0.0 1.0 8.1 0.0 0.1 17.9 22.3 1.1 58.4 3.3 90.5 43.6 CASP10 "FLICE-2, MCH4" ENSG00000003400 "Caspase 10" Q92851 2 201182898-201229406 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 71.3;NK-cells: 44.3;Paneth cells: 44.5;Plasma cells: 49.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HUVEC TERT2: 25.3" "Low region specificity" "Detected in all" "CAB003780, HPA017059" Approved Approved "Golgi apparatus,Vesicles" NA NA "Cluster 24: B-cells - Unknown function" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 1: K-562 - Erythropoiesis" "Cluster 53: Intestinal epithelial cells - Unknown function" "Golgi apparatus" Vesicles "CAB003780: AB_289592, HPA017059: AB_1846040" "unprognostic (4.01e-2)" "unprognostic (8.24e-2)" "unprognostic (4.80e-1)" "unprognostic (1.28e-3)" "unprognostic (4.74e-2)" "unprognostic (2.25e-1)" "prognostic unfavorable (8.54e-4)" "unprognostic (1.73e-2)" "unprognostic (1.48e-2)" "unprognostic (3.68e-2)" "unprognostic (1.91e-1)" "unprognostic (1.04e-1)" "prognostic unfavorable (6.05e-7)" "unprognostic (3.23e-2)" "unprognostic (2.19e-2)" "unprognostic (4.49e-2)" "unprognostic (1.38e-2)" 8.8 2.4 5.7 9.2 5.5 19.5 6.5 4.5 5.8 4.0 4.4 13.2 21.8 3.3 6.2 8.8 5.4 7.4 6.7 4.7 5.1 8.1 6.2 11.5 8.9 6.0 5.0 1.6 4.8 2.3 1.3 9.6 5.8 3.9 13.4 1.3 5.4 3.1 4.9 5.7 18.4 5.1 5.6 22.6 10.2 1.2 7.3 8.7 5.3 2.8 10.4 9.0 5.1 5.4 4.4 3.5 0.3 0.4 0.1 0.3 7.5 0.7 4.6 0.4 1.8 4.6 9.8 0.5 7.0 2.5 1.7 2.9 0.2 2.3 1.3 2.1 4.8 12.2 4.0 15.1 1.6 8.3 12.7 0.5 2.0 5.3 0.4 0.3 25.3 5.1 14.9 17.4 0.4 0.3 15.9 7.8 0.6 6.0 2.4 8.8 0.5 18.4 8.7 6.2 0.2 0.1 4.1 0.2 1.9 3.0 0.2 7.8 10.0 0.4 0.8 3.4 0.2 18.7 12.1 0.5 4.5 6.3 0.2 5.9 11.7 0.7 6.4 16.5 5.6 8.2 5.2 3.6 6.5 7.7 7.2 6.4 2.1 8.5 19.3 6.6 1.2 7.2 5.7 5.5 4.5 5.8 4.7 5.1 6.0 5.0 5.8 5.6 7.3 5.4 20.7 19.2 10.0 0.3 15.8 6.0 2.7 10.6 5.2 0.0 1.3 0.9 1.8 8.6 9.4 9.2 0.0 1.1 20.5 71.3 1.9 16.2 1.2 7.7 7.4 29.7 2.4 14.9 0.3 10.4 0.7 4.2 26.5 12.0 7.6 0.8 26.4 7.1 9.4 0.0 0.5 21.6 4.1 26.6 17.5 0.0 0.6 16.2 7.2 33.7 22.0 0.5 44.3 0.0 0.9 8.6 44.5 0.0 49.7 2.5 26.1 8.7 24.4 0.4 0.0 2.9 2.2 0.1 0.1 6.6 4.5 0.4 12.9 4.1 16.4 10.3 CASP14 "MGC119078, MGC119079, MICE" ENSG00000105141 "Caspase 14" P31944 19 15049480-15058293 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Differentiation "Hydrolase, Protease, Thiol protease" Ichthyosis "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 24 "skin 1: 486.0" "Cell type enriched" "Detected in some" 5 "Suprabasal keratinocytes: 96.0" "Cancer enhanced" "Detected in many" "cervical cancer: 62.8" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 7 "hTCEpi: 49.0" "Not detected" "Not detected" "Not detected" "Not detected" "CAB010059, HPA027062" Enhanced Supported Nucleoplasm,Mitochondria,Cytosol NA NA 3600000 "Cluster 61: Skin - Cornification" "Cluster 30: Epithelial cell lines - Translation" "Cluster 28: Keratinocytes - Keratinization" "Nucleoplasm, Cytosol" Mitochondria "CAB010059: AB_626800, HPA027062: AB_2672101" "unprognostic (1.17e-2)" "unprognostic (6.44e-3)" "unprognostic (6.22e-2)" "unprognostic (2.77e-1)" "prognostic unfavorable (7.59e-4)" "unprognostic (9.42e-2)" "unprognostic (2.19e-2)" "prognostic unfavorable (5.96e-4)" "unprognostic (2.68e-1)" "unprognostic (4.30e-2)" "unprognostic (1.99e-1)" "unprognostic (1.97e-1)" 0.6 0.0 0.1 0.0 0.4 0.4 7.8 0.4 0.2 3.9 0.2 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.2 0.1 0.1 0.1 0.1 0.0 0.3 0.1 0.0 0.6 0.1 0.0 0.0 0.3 0.8 0.0 0.1 1.1 4.2 1.4 486.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 1.0 0.0 0.0 0.0 0.0 19.9 1.0 1.1 0.2 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 6.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 49.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.9 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.1 0.4 0.4 0.2 0.2 0.1 0.3 0.1 0.3 0.0 0.3 1.0 0.0 0.0 0.0 0.0 0.0 19.1 1.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 4.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.4 2.8 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 96.0 0.7 0.1 0.0 0.0 0.8 CASP2 "ICH1, MGC2181, NEDD2, PPP1R57" ENSG00000106144 "Caspase 2" P42575 7 143288215-143307696 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 51.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB012175, HPA050678" Approved Approved Nucleoplasm NA Yes "Cluster 38: Basophils - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 34: Spermatids - Unknown function" Nucleoplasm "CAB012175: , HPA050678: AB_2681214" "unprognostic (6.96e-2)" "prognostic favorable (7.38e-4)" "unprognostic (2.74e-2)" "unprognostic (7.51e-2)" "unprognostic (4.24e-2)" "unprognostic (2.39e-2)" "prognostic unfavorable (2.34e-4)" "unprognostic (1.74e-2)" "unprognostic (1.34e-2)" "prognostic favorable (2.89e-4)" "unprognostic (1.91e-2)" "unprognostic (1.64e-1)" "prognostic unfavorable (5.01e-6)" "unprognostic (2.66e-3)" "unprognostic (9.48e-2)" "unprognostic (1.19e-1)" "unprognostic (1.64e-1)" 10.3 6.6 6.0 13.9 6.7 40.2 10.5 7.8 6.7 11.8 6.7 11.1 10.7 10.2 9.6 15.3 10.3 7.0 8.4 5.9 6.2 9.1 6.4 10.4 22.0 7.2 6.4 9.3 8.4 11.1 5.3 12.4 7.7 7.6 12.7 7.7 11.9 6.3 3.9 17.4 15.4 9.4 5.9 19.0 9.6 9.1 6.9 27.5 8.8 5.0 27.1 7.5 11.2 10.0 27.5 25.4 28.8 51.0 15.1 17.5 15.4 27.7 13.0 25.4 27.8 26.0 31.3 52.0 25.9 18.4 19.4 27.3 29.4 22.6 34.0 45.8 22.5 31.2 40.4 18.3 8.4 60.7 37.4 13.0 18.1 31.0 11.0 11.3 22.0 41.3 26.3 32.6 27.5 27.5 109.1 64.4 36.5 27.4 26.3 79.1 14.6 32.6 15.1 23.3 31.5 34.2 54.8 24.3 17.3 19.6 26.3 23.4 24.1 22.5 15.5 40.7 28.1 27.0 28.5 59.4 24.9 72.6 41.1 69.2 17.9 17.2 24.5 21.7 24.2 25.7 33.3 25.3 17.3 28.8 24.3 28.3 21.7 24.2 34.1 21.1 38.9 15.3 6.0 6.7 7.8 6.7 5.9 6.2 7.2 6.4 7.7 5.9 6.9 10.0 14.1 9.6 8.3 4.2 17.4 15.2 7.0 9.4 6.2 4.8 19.0 13.5 6.2 17.2 7.0 7.3 8.4 20.0 19.3 8.7 3.9 8.1 36.6 10.8 17.9 16.4 10.7 9.7 11.2 7.7 14.6 9.3 8.2 20.1 10.1 22.7 18.2 7.2 10.1 6.7 8.8 11.5 0.0 16.9 23.3 51.0 11.8 12.2 21.4 4.7 20.8 4.4 13.4 4.5 22.4 9.4 5.9 8.2 13.0 5.8 9.1 4.2 4.9 15.4 0.0 8.3 10.9 13.7 25.9 16.1 13.8 5.7 16.7 9.3 15.5 7.0 CASP3 "apopain, CPP32, CPP32B, Yama" ENSG00000164305 "Caspase 3" P42574 4 184627696-184649509 "Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Plasma cells: 118.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 7 "basophil: 571.0;eosinophil: 408.6" "Lineage enriched" "Detected in all" 8 "granulocytes: 571.0" "Cell line enhanced" "Detected in all" "Karpas-707: 259.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000091, HPA002643, CAB008381" Enhanced Approved Nucleoplasm,Mitochondria NA NA 94000 "Cluster 2: Granulocytes - Unknown function" "Cluster 9: Intestine - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" Mitochondria Nucleoplasm "CAB000091: , CAB008381: AB_590737, HPA002643: AB_1846048" "unprognostic (1.38e-1)" "unprognostic (1.06e-1)" "unprognostic (2.21e-2)" "prognostic favorable (2.24e-4)" "unprognostic (2.29e-3)" "unprognostic (3.58e-2)" "unprognostic (9.57e-3)" "unprognostic (5.86e-2)" "unprognostic (3.56e-2)" "unprognostic (1.12e-2)" "unprognostic (1.70e-2)" "unprognostic (2.41e-1)" "prognostic unfavorable (2.30e-5)" "unprognostic (1.41e-2)" "unprognostic (5.74e-3)" "unprognostic (1.30e-1)" "unprognostic (4.05e-3)" 16.3 12.1 11.3 26.6 10.9 32.8 16.3 18.6 11.4 12.7 10.0 34.2 54.1 12.7 12.9 27.7 9.2 19.9 14.7 10.8 12.2 8.5 22.0 12.8 43.4 10.8 11.5 8.9 13.4 9.0 8.8 26.1 11.4 11.3 33.9 12.7 13.2 10.6 13.9 16.1 41.8 15.3 11.6 23.0 31.2 9.3 11.3 39.0 10.6 14.1 41.9 24.4 12.0 13.0 31.0 16.7 65.3 31.6 39.4 52.2 37.6 90.2 67.7 61.9 35.4 30.7 25.2 42.4 13.9 44.1 29.2 25.5 52.1 32.1 69.7 109.9 28.7 68.2 12.9 71.4 47.3 55.9 62.3 71.7 38.3 39.3 31.4 44.4 77.6 43.1 57.2 259.8 64.5 13.2 89.1 51.8 65.1 33.7 20.9 63.6 30.8 41.2 52.9 49.3 37.1 40.5 39.1 35.1 52.1 64.3 19.2 35.9 54.1 28.2 25.9 21.1 42.4 118.9 121.6 29.2 34.2 38.5 40.9 571.0 26.1 408.6 32.1 43.3 34.4 26.0 29.5 46.3 33.3 18.6 22.2 32.8 35.6 62.0 71.0 26.5 64.1 47.5 11.3 10.9 18.6 11.4 10.8 12.2 10.8 11.5 11.4 11.6 11.3 13.0 28.6 19.2 15.8 26.4 32.3 48.7 22.2 34.1 35.9 18.6 21.7 17.0 17.5 5.7 36.3 12.9 0.0 46.9 54.8 37.4 13.7 18.4 9.6 24.9 17.1 26.6 18.0 62.3 9.6 23.7 33.6 19.5 24.5 24.9 17.7 24.8 21.0 15.3 23.9 13.5 12.6 37.6 44.7 27.0 17.4 4.0 7.5 33.3 30.2 13.1 41.5 15.4 37.0 11.1 18.4 25.0 18.8 7.5 118.6 20.1 26.6 8.4 30.4 11.3 13.1 19.0 20.8 7.9 16.4 34.6 28.6 51.4 43.8 23.1 24.4 36.7 CASP4 "ICE(rel)II, ICH-2, TX" ENSG00000196954 "Caspase 4" P49662 11 104942866-104969366 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Immunity, Inflammatory response, Innate immunity, Necrosis" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "HPA027588, CAB037167" Approved Approved "Plasma membrane,Cytosol" "Intracellular and membrane" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 64: Macrophages - Immune response" "Cluster 30: Epithelial cell lines - Translation" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "Plasma membrane" "CAB037167: AB_258864, HPA027588: AB_10603781" "unprognostic (1.19e-2)" "unprognostic (3.73e-1)" "unprognostic (3.44e-1)" "unprognostic (1.99e-2)" "unprognostic (7.19e-3)" "unprognostic (2.63e-2)" "unprognostic (1.26e-2)" "unprognostic (1.56e-2)" "unprognostic (5.31e-2)" "unprognostic (2.71e-1)" "unprognostic (2.38e-3)" "unprognostic (8.39e-3)" "prognostic unfavorable (3.27e-11)" "unprognostic (6.75e-2)" "unprognostic (1.34e-1)" "unprognostic (1.79e-2)" "unprognostic (4.08e-3)" 45.7 21.7 7.0 69.4 7.2 48.5 44.4 7.4 12.4 26.4 8.6 27.6 62.4 18.4 33.1 47.7 34.9 50.1 17.8 7.5 8.0 33.3 54.1 61.3 80.2 9.7 8.1 43.2 52.5 4.7 11.0 70.2 8.7 21.7 30.7 2.0 55.2 15.5 7.5 46.7 58.8 32.2 8.3 71.1 42.4 4.9 9.0 57.2 15.6 18.1 82.1 76.5 30.5 8.7 33.8 9.5 0.0 12.9 58.2 140.4 27.8 68.0 103.2 80.5 117.0 22.4 128.5 22.3 123.1 71.5 110.4 52.7 0.0 94.3 78.8 22.4 0.4 53.1 7.4 55.8 158.2 48.5 19.2 122.6 127.0 97.9 144.4 104.7 143.8 0.5 1.3 0.0 64.4 2.8 26.1 46.7 0.0 71.6 28.2 21.4 21.5 14.2 64.9 46.2 0.6 0.4 60.8 31.6 49.3 0.7 11.9 62.5 93.2 84.4 30.4 80.8 40.5 0.0 0.0 0.3 42.2 105.5 63.4 136.4 292.0 50.6 208.9 312.9 224.8 141.9 155.6 193.9 205.5 144.4 93.4 138.5 667.2 226.2 255.4 35.4 257.9 410.9 7.0 7.2 7.4 12.4 7.5 8.0 9.7 8.1 8.7 8.3 9.0 8.7 78.1 60.9 60.8 0.3 87.4 55.8 63.3 130.1 21.1 0.0 40.8 48.4 5.6 47.1 107.0 22.0 0.0 129.1 80.4 12.4 15.6 157.5 0.6 35.9 27.7 73.0 20.9 12.4 0.0 189.9 103.0 53.6 33.1 45.7 34.8 32.6 82.1 34.7 116.7 0.0 0.2 37.8 73.2 168.0 81.2 2.1 29.2 105.2 30.2 23.4 141.5 1.9 177.1 1.5 0.2 148.5 8.6 20.7 50.5 31.1 85.4 41.1 86.1 0.4 6.6 38.1 34.2 0.2 0.5 25.8 45.9 115.9 102.1 36.8 32.9 80.0 CASP5 ICE(rel)III ENSG00000137757 "Caspase 5" P51878 11 104994235-105023168 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 5.0;intestine: 16.8;lymphoid tissue: 14.6" "Cell type enhanced" "Detected in some" "Distal enterocytes: 31.4;Paneth cells: 18.7;Proximal enterocytes: 17.2;Undifferentiated cells: 7.3" "Group enriched" "Detected in some" 7 "colorectal cancer: 3.9;stomach cancer: 1.3" "Region enhanced" "Detected in some" "cerebral cortex: 5.0" "Group enriched" "Detected in some" 13 "intermediate monocyte: 18.1;neutrophil: 13.0;non-classical monocyte: 41.2" "Group enriched" "Detected in many" 15 "granulocytes: 13.0;monocytes: 41.2" "Cell line enriched" "Detected in single" 6 "HHSteC: 3.7" NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 9: Intestine - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 53: Intestinal epithelial cells - Unknown function" "unprognostic (4.30e-2)" "unprognostic (8.86e-2)" "unprognostic (1.07e-1)" "unprognostic (4.74e-2)" "unprognostic (1.66e-1)" "unprognostic (5.22e-2)" "unprognostic (9.90e-2)" "unprognostic (8.29e-3)" "unprognostic (1.47e-1)" "unprognostic (4.38e-3)" "unprognostic (7.39e-3)" "unprognostic (3.25e-1)" "unprognostic (1.82e-9)" "unprognostic (7.30e-2)" "unprognostic (2.67e-3)" "unprognostic (1.87e-1)" "unprognostic (1.50e-1)" 0.7 0.1 0.5 14.6 0.6 0.2 0.1 0.5 5.0 0.2 0.6 15.6 10.0 0.1 0.2 0.1 0.2 0.4 0.1 0.5 0.5 0.2 0.2 1.6 0.9 0.7 0.8 0.1 0.0 0.0 0.1 0.9 1.5 0.1 12.9 0.0 0.1 0.1 0.0 0.0 16.8 1.8 0.6 2.7 0.1 0.3 0.8 0.1 0.1 0.4 0.3 2.2 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.3 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 3.7 0.0 0.0 0.1 0.4 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 18.1 0.1 0.1 0.0 0.0 1.8 0.0 0.0 0.1 13.0 0.0 41.2 0.5 0.0 1.4 0.5 0.6 0.5 5.0 0.5 0.5 0.7 0.8 1.5 0.6 0.8 0.9 0.0 3.2 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 31.4 0.0 2.3 0.7 0.0 0.0 0.1 0.0 0.0 0.1 0.2 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 5.3 0.0 4.7 0.4 0.7 0.0 4.8 0.0 1.9 2.4 0.0 0.0 0.0 0.1 0.1 18.7 0.0 0.0 0.0 17.2 0.0 0.8 0.0 0.0 0.2 0.1 0.5 0.7 0.0 0.0 0.0 0.3 0.0 7.3 0.1 CASP6 MCH2 ENSG00000138794 "Caspase 6" P55212 4 109688622-109703583 "Cancer-related genes, Enzymes, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 40.8" "Cell type enhanced" "Detected in many" "Granulosa cells: 112.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Karpas-707: 76.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003775, HPA011337, HPA024303" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 20: T-cells - T-cell receptor" "Cluster 9: Intestine - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 40: Granulosa cells - Unknown function" Cytosol Nucleoplasm "CAB003775: AB_562064, HPA011337: AB_1846053, HPA024303: AB_1846052" "unprognostic (1.07e-1)" "unprognostic (1.91e-1)" "prognostic favorable (2.64e-5)" "unprognostic (1.45e-2)" "unprognostic (1.90e-1)" "unprognostic (1.46e-1)" "unprognostic (3.03e-3)" "unprognostic (9.87e-2)" "unprognostic (2.73e-2)" "unprognostic (2.59e-3)" "unprognostic (1.15e-2)" "unprognostic (6.78e-2)" "unprognostic (2.44e-1)" "unprognostic (8.74e-3)" "unprognostic (2.18e-1)" "unprognostic (2.41e-1)" "prognostic favorable (9.93e-4)" 6.5 6.7 3.9 8.4 4.0 10.8 10.5 4.3 5.4 7.6 4.0 35.3 40.8 7.7 5.1 7.4 7.6 9.3 5.6 3.8 4.0 11.5 18.1 7.8 9.6 3.7 3.7 8.3 13.3 4.8 4.2 4.8 3.8 9.1 31.5 3.0 8.6 6.5 3.3 10.7 36.8 7.4 3.8 8.0 15.8 1.8 3.7 11.5 8.5 2.4 7.7 8.1 7.0 4.3 26.6 8.4 16.5 14.8 11.0 11.2 24.3 15.3 9.2 12.4 13.4 13.8 50.3 2.7 16.4 14.7 17.3 12.1 19.7 21.8 8.4 43.5 13.0 22.8 7.1 12.9 9.4 23.5 15.7 12.6 15.1 12.4 2.8 17.1 22.9 30.1 29.9 76.1 19.2 13.7 62.0 14.4 12.7 17.1 16.1 20.5 10.8 13.3 39.6 24.8 17.2 13.2 15.0 25.7 8.8 19.6 11.0 8.0 20.3 12.8 14.6 6.6 16.7 11.4 23.0 2.8 17.1 26.9 7.1 16.3 6.9 8.9 6.3 6.9 7.0 6.1 23.8 12.3 8.8 8.6 28.0 16.1 1.4 7.5 11.2 11.6 24.8 9.4 3.9 4.0 4.3 5.4 3.8 4.0 3.7 3.7 3.8 3.8 3.7 4.3 10.5 16.0 14.6 5.2 7.7 10.8 10.2 26.7 12.0 6.9 23.6 16.0 4.1 28.6 23.2 20.2 6.2 20.9 7.6 54.0 9.8 40.8 2.6 19.8 9.5 12.2 59.2 19.7 6.4 46.4 41.1 13.4 18.3 23.3 10.1 112.3 9.7 20.4 19.8 0.0 7.3 53.9 32.6 8.7 9.3 1.7 12.8 14.5 1.8 2.8 17.9 16.0 6.2 5.5 5.8 45.9 52.5 9.8 8.8 7.4 71.7 35.7 18.6 1.3 6.6 7.6 12.3 1.9 8.6 10.8 11.6 5.7 17.5 12.4 74.2 8.0 CASP7 "CMH-1, ICE-LAP3, MCH3" ENSG00000165806 "Caspase 7" P55210 10 113679162-113730907 "Cancer-related genes, Enzymes, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 229.1;Paneth cells: 113.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" CAB025563 Enhanced NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 9: Intestine - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB025563: " "prognostic favorable (2.11e-4)" "unprognostic (3.18e-2)" "unprognostic (2.82e-2)" "unprognostic (2.18e-1)" "unprognostic (2.85e-1)" "unprognostic (1.33e-1)" "unprognostic (2.63e-3)" "unprognostic (3.96e-1)" "unprognostic (2.04e-1)" "unprognostic (1.22e-2)" "unprognostic (1.07e-1)" "unprognostic (2.35e-2)" "prognostic unfavorable (5.90e-4)" "unprognostic (5.45e-3)" "unprognostic (2.62e-1)" "unprognostic (2.86e-1)" "unprognostic (4.33e-3)" 21.0 10.3 11.8 26.2 12.2 8.4 18.6 11.5 20.4 18.4 12.8 75.1 65.3 16.3 10.5 15.4 17.9 16.8 11.3 11.8 12.0 19.6 23.6 24.9 16.9 12.3 12.5 16.2 22.4 10.4 7.0 20.9 11.9 21.3 58.2 6.8 34.1 12.3 13.8 17.4 68.1 18.5 11.4 17.5 45.5 6.8 12.8 19.8 10.2 14.5 18.4 31.6 16.1 12.8 28.9 29.4 24.1 13.0 43.4 37.5 16.7 32.9 49.9 56.1 69.7 22.4 51.0 30.1 19.0 29.8 21.1 24.8 30.4 24.2 39.5 46.9 41.0 19.6 22.0 38.0 28.9 20.9 24.7 24.5 15.9 32.0 13.3 25.0 75.4 28.2 5.3 39.8 21.1 38.2 51.1 16.0 4.4 31.7 17.3 51.7 98.0 18.1 44.8 21.4 1.9 14.4 24.9 35.5 17.6 23.1 43.1 18.4 37.8 12.8 24.1 13.5 27.7 30.7 20.1 0.8 13.1 38.7 14.3 22.9 14.7 11.7 11.1 21.3 9.5 11.5 9.2 14.1 10.4 9.2 7.1 9.7 2.6 7.4 18.5 1.4 14.0 9.8 11.8 12.2 11.5 20.4 11.8 12.0 12.3 12.5 11.9 11.4 12.8 12.8 36.3 9.6 12.3 27.4 13.8 19.8 21.2 26.0 13.1 0.6 15.8 9.9 2.5 11.5 26.2 22.0 0.0 12.4 10.3 229.1 11.7 46.1 0.3 21.0 22.9 23.8 9.6 4.0 1.6 39.0 25.5 16.2 30.1 13.5 12.7 10.9 17.2 15.6 17.0 0.0 1.1 81.1 28.5 12.8 6.9 0.6 9.6 18.4 7.2 10.3 68.9 7.9 13.4 1.0 0.8 37.2 113.4 4.1 21.5 42.6 88.0 25.9 42.8 1.7 19.7 12.3 16.3 2.9 28.2 13.3 14.8 10.9 15.7 5.2 50.7 39.0 CASP8 "Casp-8, FLICE, MACH, MCH5" ENSG00000064012 "Caspase 8" Q14790 2 201233443-201287711 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Host-virus interaction" "Hydrolase, Protease, Thiol protease" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 66.6" "Cell type enhanced" "Detected in many" "dendritic cells: 107.4;NK-cells: 132.8;Plasma cells: 73.4;T-cells: 86.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA001302, CAB002047, HPA005688, HPA006191" Approved Supported Nucleoplasm,Cytosol No No "Cluster 5: Granulocytes - Unknown function" "Cluster 2: Immune cells - Immune response" "Cluster 29: U-266 - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" Cytosol Nucleoplasm "CAB002047: AB_563465, HPA001302: AB_1846057, HPA005688: AB_1846056, HPA006191: AB_2667535" "unprognostic (5.21e-3)" "unprognostic (2.10e-1)" "unprognostic (1.83e-2)" "unprognostic (9.69e-3)" "unprognostic (2.09e-1)" "unprognostic (5.60e-2)" "prognostic unfavorable (3.02e-4)" "unprognostic (2.10e-1)" "unprognostic (4.79e-2)" "prognostic favorable (1.25e-4)" "unprognostic (7.75e-2)" "unprognostic (5.11e-2)" "prognostic unfavorable (1.27e-6)" "unprognostic (7.67e-3)" "unprognostic (2.43e-1)" "unprognostic (2.53e-1)" "unprognostic (4.53e-3)" 11.5 10.2 1.7 28.6 2.0 66.6 13.9 1.3 2.1 9.6 4.2 16.1 20.5 8.5 13.2 12.9 14.1 13.2 5.2 2.1 1.8 10.7 14.1 19.6 37.7 3.4 3.0 7.7 7.8 2.9 3.4 9.9 2.7 6.9 17.6 4.6 8.4 7.3 3.3 12.1 26.0 9.9 2.4 37.1 15.9 4.3 2.6 24.4 7.9 3.0 29.7 18.0 8.6 2.4 33.6 26.6 7.7 22.2 20.7 29.7 12.0 13.8 13.2 16.0 26.2 36.1 54.9 3.7 29.6 10.7 28.7 16.2 17.2 16.1 31.3 21.1 15.4 31.0 21.9 35.1 17.1 25.6 33.8 25.9 38.0 30.1 23.9 13.4 15.1 26.9 28.6 69.1 14.7 13.1 32.1 25.9 12.6 17.5 23.7 24.7 15.9 55.4 30.8 35.3 2.3 1.1 17.9 29.8 18.0 7.0 8.0 19.1 19.6 17.3 18.0 9.0 10.9 63.1 30.2 21.2 25.3 33.1 16.6 76.1 39.5 77.1 70.7 51.2 66.0 40.9 57.8 75.9 41.6 24.0 37.0 47.2 153.6 70.6 51.5 18.6 75.0 40.6 1.7 2.0 1.3 2.1 2.1 1.8 3.4 3.0 2.7 2.4 2.6 2.4 8.5 25.6 26.7 0.7 50.0 7.5 13.0 6.1 10.2 2.1 12.9 9.3 2.5 10.0 13.0 5.5 10.4 8.5 107.4 37.0 15.6 12.3 5.9 25.6 8.1 10.1 4.2 10.5 2.5 8.4 12.1 9.5 19.4 27.2 24.6 10.4 5.3 11.7 11.9 0.0 1.3 15.2 4.1 25.3 15.7 1.9 2.5 25.0 7.2 10.3 35.6 0.2 132.8 1.0 0.5 11.2 30.1 0.7 73.4 9.7 22.3 23.6 14.2 0.4 0.0 4.5 3.7 0.8 0.4 13.1 7.7 3.4 86.9 10.6 17.4 12.7 CASP9 "APAF-3, ICE-LAP6, MCH6, PPP1R56" ENSG00000132906 "Caspase 9" P55211 1 15490832-15526534 "Cancer-related genes, Enzymes, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Syncytiotrophoblasts: 35.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001473, CAB004348, HPA046488" Approved Approved Mitochondria NA NA "Cluster 46: Basophils - DNA binding" "Cluster 35: Non-specific - Unknown function" "Cluster 20: HeLa - Mitochondria" "Cluster 41: Macrophages - Immune response" Mitochondria "CAB004348: AB_673489, HPA001473: AB_1078401, HPA046488: AB_2679670" "prognostic favorable (5.91e-4)" "unprognostic (2.42e-1)" "unprognostic (8.94e-3)" "unprognostic (7.84e-2)" "unprognostic (1.93e-2)" "unprognostic (8.54e-3)" "unprognostic (1.90e-3)" "unprognostic (6.75e-2)" "unprognostic (2.58e-1)" "unprognostic (1.29e-1)" "unprognostic (9.09e-2)" "unprognostic (1.98e-1)" "unprognostic (1.39e-2)" "unprognostic (2.35e-1)" "unprognostic (3.21e-2)" "unprognostic (5.48e-2)" "prognostic favorable (1.67e-5)" 12.0 50.8 14.1 7.0 14.5 11.5 8.9 16.1 18.8 19.3 13.3 11.8 6.4 14.4 12.5 14.1 22.5 9.4 16.4 14.2 13.0 20.7 14.8 10.8 6.9 14.8 14.2 57.6 37.8 12.0 32.4 7.1 14.1 19.2 5.3 12.3 8.9 9.8 12.7 5.5 11.0 6.6 13.6 10.6 12.4 25.9 14.6 8.7 25.9 9.4 7.9 12.9 12.8 17.1 10.4 17.8 4.6 8.9 11.0 5.4 5.3 7.5 9.9 11.1 12.7 12.5 10.1 13.4 16.2 7.5 13.1 4.2 10.5 8.2 11.7 5.9 11.6 9.8 32.8 10.8 10.8 10.6 11.5 9.7 11.5 15.3 3.8 8.3 8.7 13.3 20.4 13.4 5.8 5.2 3.3 8.6 5.9 11.3 8.2 7.4 13.4 16.4 12.3 6.7 4.4 9.0 9.6 1.8 15.6 12.1 5.7 7.9 4.8 13.8 5.8 15.6 5.1 13.3 21.5 16.3 8.9 9.9 5.0 54.2 24.7 54.8 11.0 17.4 8.2 21.3 6.6 7.6 25.1 30.0 3.1 4.8 36.3 29.3 18.9 11.4 6.9 15.0 14.1 14.5 16.1 18.8 14.2 13.0 14.8 14.2 14.1 13.6 14.6 17.1 2.8 3.2 3.7 18.3 17.1 2.9 8.2 5.0 4.6 3.2 7.0 4.7 9.3 11.5 7.3 18.4 6.2 17.0 8.0 7.0 1.9 7.5 12.6 10.9 5.2 3.3 3.0 5.7 7.9 9.1 10.8 5.6 12.8 7.6 1.3 5.7 4.2 4.7 9.5 5.0 9.9 6.3 6.1 4.8 12.9 5.5 2.1 12.9 0.0 6.5 4.8 7.5 10.3 9.5 8.8 8.4 7.3 3.8 9.9 4.0 9.8 7.2 8.9 6.3 0.0 5.3 9.7 16.4 7.1 6.0 2.4 35.7 6.4 7.9 5.6 7.4 CELA1 ELA1 ENSG00000139610 "Chymotrypsin like elastase 1" Q9UNI1 12 51328442-51346679 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "adrenal gland: 2.2;pancreas: 6.6" "Cell type enhanced" "Detected in some" "Exocrine glandular cells: 16.6;Extravillous trophoblasts: 2.9;Kupffer cells: 7.9;NK-cells: 3.1" "Cancer enhanced" "Detected in single" "testis cancer: 0.5" "Not detected" "Not detected" "Immune cell enhanced" "Detected in many" "basophil: 12.4;naive CD4 T-cell: 12.3" "Group enriched" "Detected in many" 8 "granulocytes: 12.4;T-cells: 12.3" "Cell line enriched" "Detected in some" 4 "BEWO: 5.4" "Low region specificity" "Detected in all" "Not detected" "Not detected" "Secreted - unknown location" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 25: Pancreas - Digestion" "Cluster 28: BEWO - Transcription regulation" "Cluster 1: Pancreatic cells - Digestion" "unprognostic (3.54e-2)" "unprognostic (1.64e-1)" "unprognostic (4.73e-2)" "unprognostic (2.73e-1)" "unprognostic (1.70e-1)" "unprognostic (1.52e-1)" "unprognostic (1.13e-1)" "unprognostic (3.59e-2)" "unprognostic (3.83e-3)" "unprognostic (2.52e-1)" "unprognostic (1.46e-1)" 0.0 2.2 0.0 0.2 0.1 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.8 0.1 0.0 0.0 6.6 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.1 0.5 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 5.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 12.4 1.6 0.1 1.0 0.8 0.4 0.3 2.7 0.8 1.0 0.0 12.3 5.9 0.2 0.2 1.0 0.0 0.3 1.2 0.0 0.1 0.0 0.2 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.4 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 16.6 2.9 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.8 0.0 0.1 0.0 0.0 7.9 0.0 0.0 0.0 1.4 0.0 0.0 1.8 0.0 3.1 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.9 0.0 0.0 0.5 1.4 0.2 0.0 0.0 CELA2A ELA2A ENSG00000142615 "Chymotrypsin like elastase 2A" P08217 1 15456728-15472091 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Diabetes mellitus, Disease variant, Obesity" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 2325 "pancreas: 162732.5" "Cell type enriched" "Detected in some" 34 "Exocrine glandular cells: 7828.2" "Cancer enriched" "Detected in single" 3818 "pancreatic cancer: 463.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "HMC-1: 1.2" "Secreted to digestive system" NA NA 2700000 "Cluster 25: Pancreas - Digestion" "Cluster 3: HMC-1 - Innate immune response" "Cluster 1: Pancreatic cells - Digestion" "unprognostic (9.78e-2)" "unprognostic (3.33e-2)" "unprognostic (5.60e-2)" "unprognostic (5.27e-2)" "unprognostic (3.63e-3)" "unprognostic (2.35e-1)" "unprognostic (4.14e-1)" "unprognostic (1.96e-2)" "unprognostic (1.38e-1)" "unprognostic (2.48e-1)" "unprognostic (3.94e-9)" "unprognostic (4.10e-2)" "unprognostic (3.42e-1)" "unprognostic (3.55e-2)" 7.9 5.5 0.0 2.6 0.0 1.1 4.4 0.2 0.1 3.9 0.0 2.0 18.5 2.1 0.0 2.3 1.1 0.0 26.9 0.0 0.0 1.6 5.8 1.2 4.3 0.0 0.0 70.0 162732.5 0.0 1.3 10.2 0.0 2.7 0.0 0.0 28.0 0.0 1.6 2.2 8.7 0.0 0.0 2.2 15.4 2.0 0.0 0.0 1.1 0.0 0.0 0.9 1.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.3 0.0 0.0 0.0 0.1 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 5.8 0.1 0.3 0.3 0.3 0.0 0.0 1.1 7828.2 0.0 0.2 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.4 0.0 0.0 1.3 0.0 0.0 20.7 0.0 0.0 0.0 0.1 227.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.8 0.9 0.0 0.0 0.0 0.0 0.0 0.1 1.6 0.0 0.1 CELA2B "ELA2B, RP11-265F14.2" ENSG00000215704 "Chymotrypsin like elastase 2B" P08218 1 15465909-15491395 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 1672 "pancreas: 20446.9" "Cell type enriched" "Detected in some" 73 "Exocrine glandular cells: 1227.6" "Cancer enriched" "Detected in single" 574 "pancreatic cancer: 69.9" "Group enriched" "Detected in some" 4 "cerebellum: 2.0;cerebral cortex: 3.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 5 "U-138 MG: 3.9" "Secreted to digestive system" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 25: Pancreas - Digestion" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 1: Pancreatic cells - Digestion" "unprognostic (4.36e-3)" "unprognostic (5.45e-2)" "unprognostic (6.66e-2)" "unprognostic (5.31e-3)" "unprognostic (4.47e-3)" "unprognostic (1.37e-3)" "unprognostic (4.66e-2)" "unprognostic (6.32e-2)" "unprognostic (2.73e-1)" "unprognostic (2.44e-1)" "unprognostic (2.94e-1)" "unprognostic (3.85e-2)" "unprognostic (1.22e-6)" "unprognostic (2.47e-1)" "unprognostic (6.67e-2)" "unprognostic (1.88e-1)" "unprognostic (7.80e-2)" 1.1 3.0 0.0 0.5 0.0 1.0 0.6 2.0 3.2 0.4 0.0 0.2 3.7 0.4 0.1 0.3 0.1 0.6 4.5 0.3 0.6 0.2 0.6 0.3 1.2 0.2 0.2 12.2 20446.9 0.0 0.1 1.2 0.0 0.3 0.0 1.7 3.4 0.0 0.3 1.0 2.4 0.0 0.0 0.3 1.2 0.7 0.4 0.0 0.8 0.0 0.0 0.1 0.1 0.3 0.0 0.6 0.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.3 0.5 0.8 0.4 0.1 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.3 0.0 0.6 0.1 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.2 0.1 0.0 0.0 3.9 0.0 0.0 0.0 0.3 0.0 0.1 0.1 0.0 0.0 0.9 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 3.2 0.3 0.6 0.2 0.2 0.0 0.0 0.4 0.3 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.3 0.1 0.0 0.0 0.0 0.0 1.4 1227.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.5 0.1 16.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.5 0.0 0.0 CELA3A "ELA3, ELA3A" ENSG00000142789 "Chymotrypsin like elastase 3A" P09093 1 22001657-22012542 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 2216 "pancreas: 262614.2" "Cell type enriched" "Detected in some" 56 "Exocrine glandular cells: 34710.4" "Cancer enriched" "Detected in some" 2497 "pancreatic cancer: 1481.6" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 28 "MOLT-4: 24.9" "HPA028086, HPA045650" Supported Approved Cytosol "Secreted to digestive system" NA NA "Cluster 25: Pancreas - Digestion" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 1: Pancreatic cells - Digestion" Cytosol "HPA028086: AB_2672482, HPA045650: AB_2679407" "unprognostic (1.27e-1)" "unprognostic (2.71e-1)" "unprognostic (1.79e-1)" "unprognostic (6.32e-2)" "unprognostic (2.67e-1)" 20.0 4.5 0.0 3.0 0.0 2.8 11.6 0.0 0.0 12.9 0.0 4.5 21.3 4.1 0.0 7.4 3.0 0.1 44.6 0.0 0.0 4.1 13.5 3.0 6.0 0.0 0.0 118.5 262614.2 0.0 6.9 14.9 0.0 8.8 0.0 0.0 44.0 0.0 3.9 5.2 12.2 0.0 0.0 6.3 47.7 3.2 0.0 0.3 3.1 0.0 0.0 2.9 4.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 24.9 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 25.5 40.7 0.1 0.0 0.6 0.0 0.0 0.1 34710.4 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 197.1 0.3 2.4 0.0 0.0 94.0 0.0 0.0 0.0 0.0 619.0 1.1 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 2.8 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CELA3B "CBPP, ELA3B" ENSG00000219073 "Chymotrypsin like elastase 3B" P08861 1 21977022-21998642 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 2088 "pancreas: 49621.1" "Cell type enriched" "Detected in some" 45 "Exocrine glandular cells: 14881.1" "Cancer enriched" "Detected in single" 1218 "pancreatic cancer: 408.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA028086, HPA045650" Supported Approved Cytosol "Secreted to digestive system" NA NA "Cluster 25: Pancreas - Digestion" "Cluster 1: Pancreatic cells - Digestion" Cytosol "HPA028086: AB_2672482, HPA045650: AB_2679407" "unprognostic (2.89e-1)" "unprognostic (4.01e-3)" "unprognostic (6.53e-3)" "unprognostic (1.30e-1)" "unprognostic (1.29e-1)" "unprognostic (6.40e-2)" 9.0 1.8 0.0 0.6 0.0 0.8 4.5 0.0 0.0 4.4 0.0 1.8 6.2 1.6 0.1 2.6 1.2 0.0 8.4 0.0 0.0 1.6 5.0 1.2 1.1 0.0 0.0 23.7 49621.1 0.0 2.2 3.4 0.0 3.1 0.1 0.0 9.5 0.0 1.6 1.9 2.6 0.0 0.0 2.3 17.2 2.4 0.0 0.0 1.2 0.0 0.0 1.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 12.7 0.0 10.4 78.6 0.3 0.0 0.6 0.0 0.0 0.2 14881.1 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.5 0.0 0.0 0.0 309.9 0.9 0.9 0.0 0.0 60.4 0.0 0.0 0.0 0.2 325.6 16.0 0.7 0.0 0.0 5.7 0.0 0.0 0.0 0.0 0.0 1.3 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.6 0.0 CFB "BF, BFD, H2-Bf" ENSG00000243649 "Complement factor B" P00751 6 31945650-31952084 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Complement alternate pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Age-related macular degeneration, Disease variant, Hemolytic uremic syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 18 "liver: 2613.2" "Cell type enhanced" "Detected in many" "Ductal cells: 873.6;Exocrine glandular cells: 197.3;Hepatocytes: 284.0;Pancreatic endocrine cells: 318.0;Proximal enterocytes: 139.7" "Cancer enhanced" "Detected in all" "liver cancer: 78.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC diff: 15.0;ASC TERT1: 23.0;EFO-21: 25.1;fHDF/TERT166: 14.1;HSkMC: 19.1;U-87 MG: 10.1" "Low region specificity" "Detected in all" "HPA000951, HPA001817, HPA001832, CAB016381" Supported Approved "Endoplasmic reticulum,Vesicles,Cell Junctions" "Secreted to blood" NA NA 879000000 120000000000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 62: Liver - Hemostasis" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 1: Pancreatic cells - Digestion" "Endoplasmic reticulum, Vesicles" "Cell Junctions" "CAB016381: AB_627562, HPA000951: AB_2797216, HPA001817: AB_1078779, HPA001832: AB_1078778" "prognostic favorable (2.76e-5)" "unprognostic (1.02e-1)" "unprognostic (1.44e-1)" "unprognostic (7.94e-2)" "unprognostic (1.82e-2)" "unprognostic (8.56e-2)" "unprognostic (8.08e-3)" "unprognostic (8.81e-2)" "unprognostic (3.51e-1)" "unprognostic (2.26e-2)" "unprognostic (1.32e-2)" "unprognostic (6.57e-2)" "prognostic unfavorable (1.53e-5)" "unprognostic (1.36e-1)" "unprognostic (5.13e-2)" "unprognostic (1.05e-2)" "unprognostic (3.68e-2)" 143.7 18.0 3.6 32.8 3.6 0.1 28.5 3.4 9.9 16.3 3.9 22.3 28.1 8.2 14.2 24.1 53.7 0.8 42.6 3.7 3.4 58.7 2613.2 39.2 4.2 4.1 3.7 9.9 51.8 0.2 17.7 5.0 3.8 60.3 14.5 1.4 43.3 0.0 3.0 7.7 73.1 48.3 3.4 12.9 54.5 2.1 3.7 1.9 15.5 0.7 6.7 17.8 9.2 3.6 0.5 1.9 0.1 0.0 15.0 23.0 0.1 0.0 0.2 1.1 0.0 0.1 8.6 0.1 25.1 14.1 0.6 6.0 0.0 1.8 1.2 1.0 0.3 0.7 0.4 0.5 0.0 1.0 0.4 19.1 0.4 0.6 0.5 1.3 0.2 0.1 0.3 0.7 0.1 0.2 0.1 0.3 0.4 0.0 0.4 0.3 0.3 1.3 1.7 0.5 0.0 0.1 0.0 1.3 0.0 0.0 0.0 0.2 0.0 3.4 1.2 0.4 0.4 0.7 2.1 1.0 10.1 0.6 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 3.6 3.6 3.4 9.9 3.7 3.4 4.1 3.7 3.8 3.4 3.7 3.6 1.0 0.0 16.9 0.0 2.6 0.8 0.9 64.8 11.4 0.3 4.9 0.9 0.4 44.3 127.3 5.5 0.0 0.1 0.0 3.7 3.9 873.6 0.0 1.9 0.4 3.9 2.4 16.0 0.2 197.3 0.2 34.6 20.9 1.2 0.0 0.0 11.7 284.0 1.0 0.0 0.2 8.5 18.3 19.7 1.0 0.0 2.8 1.1 0.0 5.6 18.1 0.4 0.0 0.0 0.0 318.0 10.6 0.0 0.1 8.6 139.7 17.1 75.4 0.7 0.0 1.0 12.6 0.1 0.1 3.9 1.8 1.6 1.6 0.0 12.4 4.5 CFD "ADN, DF, PFD" ENSG00000197766 "Complement factor D" P00746 19 859664-863641 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins" "Complement alternate pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 1496.7;breast: 993.2" "Group enriched" "Detected in many" 6 "Fibroblasts: 9365.5;Leydig cells: 5032.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 297.6" "Lineage enriched" "Detected in all" 5 "granulocytes: 297.6" "Group enriched" "Detected in many" 5 "ASC diff: 197.4;THP-1: 342.2" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Secreted to blood" NA NA 732000000 4400000000 "Cluster 2: Granulocytes - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 43: THP-1 - Innate immune response" "Cluster 50: Fibroblasts - ECM organization" "unprognostic (3.00e-2)" "unprognostic (6.09e-2)" "unprognostic (2.44e-1)" "unprognostic (1.22e-3)" "unprognostic (6.92e-2)" "unprognostic (5.28e-2)" "unprognostic (8.11e-3)" "unprognostic (2.48e-1)" "unprognostic (1.46e-2)" "unprognostic (8.10e-2)" "prognostic favorable (1.77e-4)" "unprognostic (9.53e-2)" "prognostic unfavorable (7.09e-4)" "unprognostic (1.23e-1)" "unprognostic (4.55e-2)" "unprognostic (1.92e-2)" "unprognostic (9.75e-2)" 1496.7 33.3 1.5 9.6 1.6 10.7 993.2 1.2 2.4 597.4 3.7 324.8 23.5 58.4 2.4 212.8 258.0 9.6 854.2 1.7 2.3 18.1 8.7 363.3 2.1 3.3 2.3 74.3 41.4 1.7 9.0 14.5 3.6 277.8 10.9 0.6 247.3 6.3 197.0 488.6 248.4 4.0 2.6 28.6 263.8 51.8 2.9 3.6 332.3 26.9 0.8 848.3 729.8 5.8 3.9 5.2 0.6 2.2 197.4 26.2 9.5 0.8 0.0 0.0 0.0 0.8 0.4 0.2 5.7 0.0 0.5 3.0 1.8 0.5 0.0 5.7 14.5 0.5 12.3 3.8 3.6 2.5 4.9 8.7 0.2 0.1 0.0 0.8 0.0 4.5 11.9 0.9 0.0 2.6 0.6 49.2 1.0 4.5 16.1 1.3 0.5 5.2 0.3 1.2 1.8 1.8 5.5 1.9 0.5 0.6 7.5 342.2 0.4 0.2 5.1 2.9 0.6 7.8 4.7 0.4 0.2 20.8 0.2 297.6 41.2 127.8 8.4 55.5 13.2 5.7 4.2 10.2 14.5 1.4 9.7 9.7 112.0 1.3 57.3 1.8 4.7 37.8 1.5 1.6 1.2 2.4 1.7 2.3 3.3 2.3 3.6 2.6 2.9 5.8 857.8 9.6 23.3 0.0 19.2 785.5 49.0 10.1 17.1 2.9 107.3 120.1 55.5 21.5 30.9 18.4 2.1 36.6 40.0 33.1 11.7 7.7 27.1 23.1 593.3 114.8 4.2 8.2 0.2 0.0 32.9 9365.5 113.6 15.9 17.1 0.9 30.4 2.6 272.4 1.7 0.4 8.7 0.0 424.7 1145.2 89.6 5032.4 442.5 642.1 4.7 303.6 1.3 21.6 0.0 0.1 2.9 64.8 283.2 41.0 19.7 4.3 3.4 28.4 6.5 0.0 414.3 530.2 11.4 21.3 28.6 735.9 34.3 82.8 1.2 21.0 233.2 CFI "C3b-INA, FI, IF, KAF" ENSG00000205403 "Complement factor I" P05156 4 109740694-109801999 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins" "Complement pathway, Host-virus interaction, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Age-related macular degeneration, Disease variant, Hemolytic uremic syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "liver: 1098.8" "Cell type enhanced" "Detected in many" "Cholangiocytes: 108.7;Hepatocytes: 592.5;Muller glia cells: 147.8;Proximal tubular cells: 223.6" "Cancer enhanced" "Detected in all" "liver cancer: 90.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CAPAN-2: 106.1;Hep G2: 179.8;HSkMC: 67.4;RPTEC TERT1: 190.6" "HPA001143, CAB016777, HPA024061" Supported "Secreted to blood" NA NA 12000000000 "Cluster 85: Liver - Metabolism" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "CAB016777: , HPA001143: AB_1078555, HPA024061: AB_1847129" "unprognostic (1.04e-1)" "unprognostic (5.79e-2)" "unprognostic (1.68e-1)" "unprognostic (6.32e-2)" "unprognostic (1.55e-2)" "unprognostic (8.58e-2)" "unprognostic (2.95e-2)" "unprognostic (3.00e-1)" "unprognostic (2.00e-2)" "unprognostic (5.42e-3)" "unprognostic (1.41e-1)" "unprognostic (3.61e-1)" "unprognostic (8.63e-2)" "unprognostic (1.29e-1)" "unprognostic (3.42e-2)" "unprognostic (1.74e-1)" "prognostic unfavorable (6.06e-4)" 45.1 50.2 8.1 12.6 8.2 0.1 17.4 7.7 13.2 36.8 10.4 7.4 38.0 39.2 80.3 9.3 74.0 73.0 25.0 8.3 9.6 224.9 1098.8 50.7 8.9 15.6 10.2 32.1 26.0 3.1 8.4 24.1 10.7 8.3 6.4 53.0 15.0 26.7 3.9 2.7 22.3 24.3 10.5 33.1 14.4 8.8 9.2 2.3 14.5 4.6 7.5 34.1 8.3 10.6 0.0 0.6 0.0 0.3 0.0 0.2 0.1 1.5 1.4 0.1 0.2 0.0 106.1 0.0 32.9 0.0 0.5 0.0 0.0 0.0 0.0 34.8 0.7 0.0 0.4 179.8 6.2 0.3 0.0 67.4 0.0 0.1 0.0 3.6 4.8 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 190.6 0.5 0.0 0.3 1.6 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.4 0.6 0.0 0.0 0.0 0.1 18.8 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.1 8.2 7.7 13.2 8.3 9.6 15.6 10.2 10.7 10.5 9.2 10.6 48.1 12.8 50.9 3.6 4.0 1.0 12.2 15.2 0.6 3.4 2.1 5.6 2.3 108.7 36.2 64.4 2.1 0.1 0.3 1.7 31.3 69.3 0.2 34.1 46.4 57.7 0.0 2.7 0.3 30.9 0.2 34.3 8.2 33.6 3.8 72.1 55.0 592.5 0.7 1.7 0.2 1.9 0.0 16.7 1.5 0.8 16.8 2.0 0.0 4.7 1.6 147.8 0.0 0.0 0.3 30.8 2.4 0.0 0.0 3.8 17.0 223.6 8.4 7.3 0.0 1.3 9.4 1.6 0.5 1.9 1.1 0.3 3.4 18.5 4.1 12.6 CFLAR "c-FLIP, CASH, CASP8AP1, Casper, cFLIP, CLARP, FLAME, FLIP, I-FLICE, MRIT" ENSG00000003402 "CASP8 and FADD like apoptosis regulator" O15519 2 201116154-201176687 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Apoptosis, Host-virus interaction" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Langerhans cells: 609.9;Urothelial cells: 521.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 4 "neutrophil: 392.6" "Lineage enriched" "Detected in all" 6 "granulocytes: 392.6" "Cell line enhanced" "Detected in all" "U-266/70: 214.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019044, CAB022157, CAB025216" Uncertain Supported "Nucleoplasm,Nuclear bodies,Plasma membrane,Cytosol" NA Yes "Cluster 50: Neutrophils - Cellular senescence" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 41: Macrophages - Immune response" "Nucleoplasm, Plasma membrane, Cytosol" "Nuclear bodies" "CAB022157: , CAB025216: , HPA019044: AB_10696204" "unprognostic (4.61e-2)" "unprognostic (5.32e-2)" "unprognostic (2.49e-1)" "unprognostic (1.44e-1)" "unprognostic (2.95e-2)" "prognostic favorable (2.79e-4)" "unprognostic (7.46e-2)" "unprognostic (9.01e-2)" "unprognostic (1.76e-1)" "unprognostic (6.12e-2)" "unprognostic (3.08e-2)" "unprognostic (4.91e-2)" "unprognostic (2.90e-2)" "unprognostic (7.83e-2)" "unprognostic (9.13e-2)" "unprognostic (6.84e-2)" "unprognostic (2.24e-2)" 122.4 50.6 38.8 103.9 40.9 247.6 83.1 54.1 47.4 57.0 75.6 86.0 59.2 57.9 60.6 68.0 66.6 71.6 184.8 39.4 32.7 57.5 59.2 174.6 91.1 46.5 40.5 38.3 40.7 31.8 29.4 94.0 42.1 65.6 56.4 12.4 58.0 63.2 222.8 51.0 64.8 58.8 36.6 98.1 56.5 25.3 51.9 54.1 78.8 89.2 107.3 78.7 61.7 46.1 21.5 42.9 30.0 17.9 92.3 71.0 37.5 53.6 92.1 34.3 41.6 50.4 78.4 5.8 49.6 62.5 41.6 15.5 9.8 40.3 53.9 160.7 29.9 32.3 38.4 82.2 63.6 24.2 102.2 76.8 39.6 58.2 50.3 41.7 176.7 7.3 110.8 131.2 63.1 17.9 11.3 96.3 10.2 17.2 32.7 11.7 7.2 46.5 42.5 44.0 6.6 11.8 35.7 31.2 43.2 19.6 22.1 44.8 193.6 71.0 29.5 26.7 26.1 214.6 76.2 35.9 50.6 19.5 36.3 91.8 60.3 70.3 54.4 61.8 48.4 25.6 46.5 52.1 33.4 20.9 29.5 38.3 392.6 45.2 68.5 23.0 60.7 42.0 38.8 40.9 54.1 47.4 39.4 32.7 46.5 40.5 42.1 36.6 51.9 46.1 191.3 451.9 234.9 30.3 126.4 54.8 229.6 164.9 29.0 10.9 38.9 30.0 205.8 102.9 206.7 69.9 31.3 77.2 166.2 132.5 74.3 148.8 83.3 202.8 75.0 261.0 95.1 59.1 6.9 72.5 34.8 89.5 73.4 219.2 81.6 93.4 201.0 97.5 68.6 13.5 16.8 76.8 40.7 123.2 609.9 44.8 51.9 278.0 97.8 146.1 247.0 23.4 276.0 29.7 56.8 166.4 155.6 49.7 317.8 386.0 116.7 101.5 276.1 30.7 39.5 113.2 77.9 14.4 12.2 33.2 86.1 70.1 168.3 56.1 50.9 521.3 CLPP ENSG00000125656 "Caseinolytic mitochondrial matrix peptidase proteolytic subunit" Q16740 19 6361531-6370242 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Deafness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 229.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA010649 Supported Supported Mitochondria NA NA 8500 "Cluster 20: T-cells - T-cell receptor" "Cluster 39: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 10: Non-specific - Unknown function" Mitochondria "HPA010649: AB_1078538" "unprognostic (2.28e-1)" "unprognostic (7.14e-2)" "unprognostic (2.82e-1)" "unprognostic (4.34e-2)" "unprognostic (2.17e-2)" "unprognostic (1.15e-2)" "unprognostic (6.17e-3)" "unprognostic (7.43e-2)" "unprognostic (2.76e-1)" "unprognostic (1.31e-1)" "prognostic favorable (6.50e-4)" "unprognostic (1.21e-1)" "unprognostic (5.65e-2)" "unprognostic (6.97e-2)" "unprognostic (1.83e-1)" "unprognostic (1.03e-1)" "unprognostic (5.86e-3)" 48.6 65.8 52.0 41.5 51.5 42.9 45.1 52.2 63.8 39.1 58.0 46.6 47.4 41.1 17.8 56.1 40.1 20.8 78.0 50.9 52.7 60.5 90.7 39.7 47.7 52.8 52.4 38.5 53.6 36.6 44.5 25.4 49.5 41.0 22.9 15.6 48.3 31.2 146.8 47.5 43.6 25.1 51.8 45.6 55.6 45.2 54.5 45.2 36.1 59.3 35.6 44.6 37.9 53.9 146.7 98.2 61.2 113.9 38.7 54.8 62.4 76.9 59.5 112.2 102.5 87.2 48.9 124.1 122.8 61.3 61.1 83.1 63.5 109.1 38.5 133.8 189.3 95.8 82.2 122.9 106.6 90.7 129.8 73.4 74.4 78.9 82.9 69.7 113.9 188.5 97.5 174.5 72.3 192.8 153.1 104.5 93.2 100.6 207.8 108.6 73.2 206.2 81.2 79.4 99.3 95.9 48.9 123.8 133.0 36.7 67.3 130.6 76.9 70.5 69.7 180.7 156.0 235.4 225.3 137.2 103.5 132.9 117.3 29.4 82.6 47.8 112.0 79.6 133.5 119.5 159.4 139.6 102.4 131.5 138.4 137.4 62.1 126.5 55.5 155.5 207.2 162.6 52.0 51.5 52.2 63.8 50.9 52.7 52.8 52.4 49.5 51.8 54.5 53.9 39.6 22.4 35.2 8.1 45.9 44.9 59.5 90.8 38.1 31.0 47.6 57.9 45.8 55.8 46.2 44.1 12.5 72.2 43.7 56.0 144.8 88.8 105.5 27.6 43.1 51.6 35.3 54.9 5.4 96.6 113.6 42.4 36.2 35.0 26.0 63.1 61.8 89.6 81.3 21.9 7.5 50.9 54.9 38.9 35.0 229.8 42.6 38.7 55.2 4.7 70.6 46.6 46.4 4.5 9.5 101.9 67.7 43.2 82.4 89.5 110.9 189.0 44.5 24.6 13.1 30.0 79.9 67.7 48.1 56.5 37.1 57.7 65.3 95.1 65.4 65.4 CMA1 ENSG00000092009 "Chymase 1" P23946 14 24505353-24508265 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "breast: 18.5" "Cell type enriched" "Detected in some" 28 "granulocytes: 53.8" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB000363, HPA052634" Enhanced Supported "Cytosol,Cytoplasmic bodies" "Secreted to blood" NA NA 3000000 "Cluster 35: T-regs - Unknown function" "Cluster 46: Fibroblasts - ECM organization" "Cluster 60: Granulocytes - Receptor signaling" "Cytoplasmic bodies" Cytosol "CAB000363: AB_2083616, HPA052634: AB_2681892" "unprognostic (1.37e-1)" "unprognostic (2.27e-3)" "unprognostic (2.04e-1)" "unprognostic (7.07e-3)" "unprognostic (1.48e-2)" "unprognostic (1.19e-1)" "unprognostic (5.79e-2)" "unprognostic (2.21e-1)" "unprognostic (8.91e-3)" "unprognostic (4.19e-3)" "unprognostic (1.29e-4)" "unprognostic (2.52e-3)" "unprognostic (7.78e-2)" "unprognostic (7.37e-2)" "unprognostic (4.98e-3)" 9.0 0.0 0.2 3.7 0.1 0.2 18.5 0.0 0.2 4.6 0.3 8.7 0.6 3.1 4.3 10.2 0.9 7.3 1.6 0.1 0.2 0.2 0.5 1.5 1.8 0.5 0.3 0.1 1.6 0.6 0.2 0.1 0.3 1.0 8.3 0.0 4.7 1.3 0.9 9.0 5.8 2.2 0.3 0.2 1.5 0.9 0.2 3.0 0.4 3.0 2.4 11.1 0.9 0.2 0.0 0.0 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.2 0.2 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.5 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.1 0.0 0.2 0.1 0.2 0.5 0.3 0.3 0.3 0.2 0.2 0.0 0.0 1.9 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 53.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.1 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.4 0.0 0.7 0.0 0.1 0.0 CNDP1 "CN1, CPGL2, HsT2308, MGC10825" ENSG00000150656 "Carnosine dipeptidase 1" Q96KN2 18 74534500-74587212 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "brain: 85.6" "Cell type enriched" "Detected in some" 10 "Oligodendrocytes: 361.7" "Cancer enhanced" "Detected in some" "glioma: 4.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 38 "U-266/84: 15.4" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA008933, HPA073283" Enhanced "Secreted to blood" NA NA 2100000000 "Cluster 70: Brain - Nervous system development" "Cluster 16: U-266 - Nucleosome" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA008933: AB_1847033, HPA073283: " "unprognostic (7.43e-3)" "unprognostic (6.00e-2)" "unprognostic (8.55e-3)" "unprognostic (3.93e-1)" "unprognostic (1.32e-1)" "unprognostic (2.17e-2)" "unprognostic (8.04e-3)" "unprognostic (1.12e-2)" "unprognostic (2.81e-1)" "unprognostic (1.16e-1)" "unprognostic (1.16e-1)" "unprognostic (1.66e-1)" "unprognostic (6.90e-3)" "unprognostic (1.14e-1)" "unprognostic (3.30e-2)" "unprognostic (1.33e-1)" "unprognostic (1.28e-1)" 0.0 0.0 27.4 0.0 74.2 0.1 0.0 80.4 39.0 0.0 6.0 0.0 1.3 0.0 0.7 0.0 0.0 0.1 0.0 30.5 51.3 0.5 12.9 0.0 0.0 85.6 76.9 0.0 0.0 0.0 0.2 0.0 74.3 0.1 0.0 0.1 0.0 0.1 1.4 0.1 0.2 0.0 39.7 0.0 0.0 0.3 74.9 0.0 0.2 0.0 0.0 0.0 0.0 80.7 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 15.4 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 27.4 74.2 80.4 39.0 30.5 51.3 85.6 76.9 74.3 39.7 74.9 80.7 0.2 0.0 0.0 0.3 0.2 0.1 0.4 0.2 0.0 0.6 0.5 0.3 0.7 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.1 8.6 0.5 0.2 0.2 0.0 2.7 1.2 0.2 0.0 0.3 0.0 1.5 0.0 0.2 0.7 35.1 0.1 0.0 1.5 0.7 0.0 1.2 1.1 3.1 0.0 0.2 0.0 1.0 0.0 0.5 0.0 3.0 361.7 0.2 0.1 0.0 0.0 0.4 0.4 24.5 0.0 1.0 0.0 0.6 0.2 1.0 0.4 0.0 0.3 0.0 0.4 0.0 0.5 0.2 CNDP2 "CN2, CPGL, FLJ10830, HsT2298, PEPA" ENSG00000133313 "Carnosine dipeptidase 2" Q96KP4 18 74495816-74523454 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Glandular and luminal cells: 334.7;Proximal enterocytes: 629.1;Proximal tubular cells: 487.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Karpas-707: 458.7;RPMI-8226: 616.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB026196, HPA036898, HPA036899" Enhanced Enhanced Nucleoplasm,Cytosol NA NA 2600000 "Cluster 27: Non-specific - Gene expression" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 2: Karpas-707 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nucleoplasm, Cytosol" "CAB026196: , HPA036898: AB_2675370, HPA036899: AB_2675371" "unprognostic (2.81e-2)" "unprognostic (9.96e-2)" "unprognostic (3.28e-1)" "unprognostic (1.19e-3)" "unprognostic (2.57e-2)" "unprognostic (5.06e-2)" "unprognostic (2.84e-2)" "unprognostic (5.35e-2)" "unprognostic (1.49e-1)" "unprognostic (9.31e-2)" "unprognostic (1.56e-3)" "unprognostic (1.15e-1)" "prognostic favorable (3.50e-6)" "unprognostic (2.37e-3)" "unprognostic (4.65e-3)" "unprognostic (1.51e-1)" "unprognostic (1.34e-1)" 54.8 40.7 125.3 75.0 147.0 25.1 60.4 139.4 156.9 136.8 113.0 83.6 190.1 44.2 122.8 78.4 140.8 94.4 63.7 123.7 133.2 327.3 261.1 82.3 86.3 143.1 137.4 34.4 100.7 58.5 48.0 75.4 144.7 122.5 79.5 42.1 57.4 101.7 26.6 47.0 255.0 37.9 140.4 137.0 103.5 20.9 143.9 52.5 159.1 22.4 82.2 94.5 47.4 157.6 64.6 85.0 60.5 57.4 72.2 42.5 252.3 66.0 61.7 88.3 87.4 49.6 67.1 80.3 81.4 72.1 69.0 95.0 92.7 124.9 62.7 121.3 36.7 80.2 42.1 79.6 104.6 158.7 119.3 64.5 93.9 76.4 136.6 50.1 78.3 94.6 86.3 458.7 59.1 71.6 84.9 75.6 91.0 42.4 50.3 91.3 69.4 616.6 346.1 264.1 65.3 34.2 51.6 360.2 91.6 143.0 151.5 64.0 82.5 93.9 79.5 21.2 45.2 85.5 380.6 108.1 63.6 113.8 80.2 37.1 115.4 49.0 77.6 166.3 84.4 102.4 61.6 72.2 185.1 110.5 65.5 72.4 15.9 124.6 174.1 161.3 94.5 135.7 125.3 147.0 139.4 156.9 123.7 133.2 143.1 137.4 144.7 140.4 143.9 157.6 39.2 73.7 62.7 16.6 55.7 9.2 40.3 48.6 12.5 33.6 76.5 36.4 26.9 77.2 56.8 119.5 16.7 157.9 47.8 99.0 187.9 168.1 3.3 187.7 49.7 49.6 65.3 23.3 8.8 154.7 130.9 23.5 63.7 334.7 12.0 34.0 40.0 119.8 216.3 43.7 10.8 82.9 75.3 122.9 24.9 4.1 18.6 79.0 17.8 13.1 90.8 86.6 55.6 15.6 51.7 108.9 103.5 16.6 44.4 65.2 629.1 487.6 73.3 31.6 13.1 15.2 22.3 8.3 7.2 27.1 9.7 109.0 38.2 32.8 99.8 53.8 COPS5 "CSN5, JAB1, MOV-34, SGN5" ENSG00000121022 "COP9 signalosome subunit 5" Q92905 8 67043079-67083783 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 347.5;Late spermatids: 427.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004242, HPA004845, HPA051531" Supported Enhanced Nucleoplasm NA NA 37000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "CAB004242: AB_627835, HPA004845: AB_1078557, HPA051531: AB_2681522" "unprognostic (1.90e-3)" "unprognostic (1.35e-1)" "unprognostic (1.61e-1)" "unprognostic (2.85e-3)" "unprognostic (2.53e-1)" "unprognostic (4.16e-2)" "unprognostic (2.04e-3)" "unprognostic (1.39e-1)" "unprognostic (2.15e-2)" "unprognostic (4.48e-2)" "unprognostic (4.74e-3)" "unprognostic (1.96e-2)" "unprognostic (1.90e-3)" "unprognostic (2.88e-2)" "unprognostic (1.76e-1)" "unprognostic (2.58e-1)" "unprognostic (1.18e-2)" 43.5 43.8 52.1 33.3 54.2 39.4 45.2 58.3 62.6 34.2 52.0 45.5 45.6 34.0 43.6 42.2 35.6 31.6 100.0 53.2 57.1 56.3 71.0 33.1 40.9 55.1 53.3 33.4 43.0 58.5 31.1 50.9 56.8 36.4 51.6 39.7 42.3 36.6 125.2 36.0 47.8 47.6 57.4 33.4 37.6 58.7 56.2 52.6 37.8 134.9 48.7 42.2 30.0 59.7 104.0 97.8 79.6 74.4 83.1 88.3 63.3 89.0 74.0 121.2 108.9 62.6 125.4 96.5 39.9 93.6 86.8 84.1 109.2 98.9 134.0 92.4 92.1 135.9 95.2 87.3 82.2 86.3 79.1 81.0 126.2 99.1 132.6 95.2 121.2 100.3 163.0 64.6 111.8 96.5 154.3 157.6 107.1 217.2 108.6 97.2 56.7 76.4 131.3 91.6 48.6 66.7 51.0 98.4 91.6 71.2 160.9 90.8 89.9 60.1 74.9 74.7 70.3 81.4 108.5 127.7 89.1 97.6 84.1 65.8 52.0 64.5 35.8 55.7 37.2 36.8 34.6 39.9 63.9 33.7 36.1 32.4 38.3 51.9 56.6 34.0 53.2 43.8 52.1 54.2 58.3 62.6 53.2 57.1 55.1 53.3 56.8 57.4 56.2 59.7 55.0 22.4 26.0 19.2 40.6 49.3 45.1 102.6 28.5 36.4 43.7 51.8 119.9 58.6 61.2 31.3 33.3 143.8 58.0 38.1 88.0 73.4 347.5 44.6 38.2 46.4 34.2 69.2 21.5 60.0 101.4 45.2 25.5 37.1 36.1 50.9 34.2 35.5 79.3 25.2 21.5 41.5 59.0 31.7 28.5 427.2 43.2 40.2 28.4 10.3 59.9 62.0 56.7 18.6 32.4 50.1 48.6 51.1 46.6 54.0 87.8 81.9 46.1 53.0 32.9 49.1 87.8 123.4 49.6 42.9 47.5 127.8 42.3 72.5 55.4 50.6 COPS6 "CSN6, MOV34-34KD" ENSG00000168090 "COP9 signalosome subunit 6" Q7L5N1 7 100088969-100092187 "Enzymes, Predicted intracellular proteins" "Host-virus interaction" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044315 Approved Supported Nucleoplasm "Intracellular and membrane" NA NA 110000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 80: Striated muscle - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA044315: AB_10959750" "unprognostic (1.48e-2)" "unprognostic (2.43e-2)" "unprognostic (6.56e-3)" "unprognostic (1.38e-1)" "unprognostic (5.84e-2)" "unprognostic (2.09e-2)" "unprognostic (3.62e-3)" "unprognostic (2.93e-2)" "unprognostic (2.00e-1)" "unprognostic (2.45e-2)" "unprognostic (4.96e-2)" "unprognostic (1.25e-1)" "prognostic unfavorable (6.72e-4)" "unprognostic (1.20e-1)" "unprognostic (3.58e-2)" "unprognostic (8.57e-2)" "unprognostic (8.77e-2)" 71.3 85.5 98.5 48.7 103.0 51.8 68.6 102.5 102.0 87.1 99.5 101.3 44.1 86.5 84.0 90.6 78.1 52.9 112.9 101.9 100.7 70.8 71.6 56.5 50.3 99.3 98.4 74.8 60.2 100.8 79.2 64.0 100.4 68.8 57.8 61.4 65.0 74.2 147.3 61.8 58.4 78.5 101.7 63.1 78.4 57.4 98.7 63.1 61.5 152.8 60.6 90.5 74.7 105.0 167.6 233.4 136.2 163.5 116.1 138.4 86.6 147.7 223.5 239.7 174.9 191.9 153.8 114.4 186.1 242.2 267.3 124.1 155.1 247.9 240.4 114.9 242.6 98.2 215.9 149.3 243.3 112.1 97.6 137.5 161.4 259.2 273.9 159.5 333.0 172.7 142.7 160.5 286.4 413.7 251.6 164.8 124.0 241.3 273.2 117.6 226.6 275.4 193.6 153.8 213.4 158.6 152.7 298.5 114.1 176.4 123.7 109.2 177.9 231.3 211.1 280.5 264.8 118.1 140.2 235.3 175.5 150.0 350.6 231.8 187.8 168.2 178.8 206.6 180.7 168.0 176.8 170.9 211.3 170.3 137.4 153.6 73.5 163.5 194.6 157.8 225.8 146.6 98.5 103.0 102.5 102.0 101.9 100.7 99.3 98.4 100.4 101.7 98.7 105.0 87.8 51.3 44.2 24.8 73.4 110.6 118.1 208.1 70.0 108.3 62.8 76.3 166.3 88.6 117.2 86.5 52.1 197.3 84.2 55.1 211.3 138.3 76.5 61.6 103.4 94.9 75.3 69.0 20.9 113.5 133.7 116.0 52.5 48.3 90.7 100.5 90.3 63.2 128.8 95.9 21.0 67.4 158.7 69.6 82.5 197.1 127.7 55.1 156.5 13.1 101.4 147.0 115.4 17.6 24.0 115.1 64.7 125.3 84.3 95.0 84.2 214.2 117.9 127.1 98.6 76.3 261.5 80.5 100.2 81.2 100.3 137.9 82.7 137.9 87.1 96.1 CORIN "ATC2, CRN, Lrp4, PRSC, TMPRSS10" ENSG00000145244 "Corin, serine peptidase" Q9Y5Q5 4 47593999-47838106 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "heart muscle: 56.9" "Cell type enriched" "Detected in some" 6 "Cardiomyocytes: 69.4" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "ASC TERT1: 44.0" "Region enhanced" "Detected in some" "basal ganglia: 2.6" "Low region specificity" "Detected in some" HPA070941 Approved "Nuclear bodies,Plasma membrane,Actin filaments" "Intracellular and membrane" Yes No "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 54: Cardiomyocytes - Muscle contraction" "Plasma membrane" "Nuclear bodies, Actin filaments" "HPA070941: AB_2686324" "unprognostic (1.05e-1)" "unprognostic (2.52e-1)" "unprognostic (1.14e-1)" "unprognostic (1.93e-1)" "unprognostic (2.10e-1)" "unprognostic (3.18e-1)" "unprognostic (3.58e-4)" "unprognostic (3.19e-1)" "unprognostic (3.67e-2)" "unprognostic (8.22e-2)" "unprognostic (9.78e-2)" "unprognostic (6.53e-2)" "unprognostic (1.18e-1)" "unprognostic (2.86e-2)" "unprognostic (5.18e-2)" "unprognostic (7.22e-2)" "unprognostic (1.33e-2)" 0.4 0.1 0.1 0.1 0.1 0.0 1.0 0.1 0.2 2.1 0.6 0.3 0.1 4.5 0.6 0.9 1.4 4.5 56.9 0.0 0.3 1.0 0.1 1.9 0.0 0.7 0.6 0.5 0.2 1.1 1.9 0.4 0.1 2.3 0.0 0.3 0.4 6.1 0.1 7.5 0.3 0.7 0.1 1.1 0.5 2.5 0.3 0.1 0.1 0.1 0.1 1.2 3.9 0.1 0.0 0.0 0.1 0.3 10.3 44.0 0.0 2.0 3.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.1 2.1 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.9 1.4 0.0 0.3 0.2 1.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.2 0.0 0.3 0.7 0.6 0.1 0.1 0.3 0.1 0.3 0.0 7.5 1.0 0.0 3.8 0.3 0.0 0.0 1.0 8.3 0.3 69.4 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 6.5 0.1 1.3 1.0 0.0 0.0 6.5 0.0 0.0 9.1 0.0 0.2 0.0 0.1 0.0 0.0 0.1 0.0 10.8 0.0 0.0 0.6 5.5 2.0 4.7 0.1 5.4 1.0 0.0 0.7 0.0 2.0 3.9 0.0 0.0 2.6 0.0 0.6 0.0 0.2 0.0 0.3 0.0 0.3 2.3 4.6 4.4 0.1 2.7 0.0 0.6 0.1 0.0 0.3 CPA1 CPA ENSG00000091704 "Carboxypeptidase A1" P15085 7 130380339-130388114 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 2326 "pancreas: 237498.3" "Cell type enriched" "Detected in some" 19 "Exocrine glandular cells: 10133.0" "Cancer enriched" "Detected in some" 639 "pancreatic cancer: 1377.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "AN3-CA: 11.8" "Not detected" "Not detected" "Low region specificity" "Detected in some" "HPA021836, CAB025197, HPA052215" Enhanced "Secreted to digestive system" NA NA 110000000 "Cluster 25: Pancreas - Digestion" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 1: Pancreatic cells - Digestion" "CAB025197: , HPA021836: AB_1846005, HPA052215: AB_2681764" "unprognostic (8.41e-2)" "unprognostic (9.24e-4)" "unprognostic (5.22e-2)" "unprognostic (1.76e-1)" "unprognostic (3.97e-1)" "unprognostic (1.76e-1)" "unprognostic (2.27e-1)" "unprognostic (1.15e-2)" "unprognostic (1.35e-1)" "unprognostic (1.34e-6)" "unprognostic (4.99e-1)" "unprognostic (1.67e-1)" "unprognostic (2.16e-1)" "unprognostic (4.37e-2)" 27.9 4.8 0.2 5.6 0.2 4.7 13.6 0.1 0.2 11.9 1.2 4.5 33.6 5.0 0.1 6.9 3.7 0.2 43.5 0.2 0.3 4.6 12.9 3.3 8.7 0.1 0.1 102.1 237498.3 0.0 5.0 18.4 0.1 6.9 0.0 0.2 39.5 0.1 4.7 6.6 20.8 0.4 0.2 7.7 21.3 5.4 0.2 0.1 3.0 0.4 0.0 2.8 4.0 0.4 0.0 0.0 0.0 11.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.4 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 2.1 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 1.7 0.0 0.2 0.0 1.5 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.1 0.2 0.2 0.3 0.1 0.1 0.1 0.2 0.2 0.4 0.1 3.2 0.0 0.3 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.9 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.0 5.9 12.0 1.9 0.0 0.1 0.1 0.0 0.0 0.0 10133.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 7.6 0.9 1.2 0.0 1.0 44.5 2.1 0.0 0.0 0.0 527.2 0.0 0.7 0.0 0.4 0.0 0.0 0.0 0.1 0.0 16.2 2.7 0.9 5.5 0.0 0.0 1.6 0.0 2.5 0.0 0.1 CPA2 ENSG00000158516 "Carboxypeptidase A2" P48052 7 130266863-130289798 "Enzymes, Metabolic proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 416 "pancreas: 45360.2" "Cell type enriched" "Detected in some" 10 "Exocrine glandular cells: 4973.8" "Cancer enriched" "Detected in many" 60 "pancreatic cancer: 411.4" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AN3-CA: 2.2;CACO-2: 3.8;RH-30: 3.0;SCLC-21H: 1.6" "Low region specificity" "Detected in all" "Not detected" "Not detected" "HPA020342, HPA021317" Enhanced Approved "Golgi apparatus" "Secreted to digestive system" NA NA 1500000 "Cluster 25: Pancreas - Digestion" "Cluster 39: CACO-2 - Unknown function" "Cluster 1: Pancreatic cells - Digestion" "Golgi apparatus" "HPA020342: AB_1846007, HPA021317: AB_1846008" "unprognostic (1.12e-1)" "unprognostic (3.97e-1)" "unprognostic (4.21e-2)" "unprognostic (1.82e-2)" "unprognostic (1.38e-1)" "unprognostic (6.76e-2)" "unprognostic (4.65e-2)" "unprognostic (1.08e-1)" "unprognostic (1.40e-1)" "unprognostic (1.84e-1)" "unprognostic (2.66e-1)" "unprognostic (3.84e-5)" "unprognostic (7.52e-2)" "unprognostic (1.42e-1)" "unprognostic (7.12e-2)" "unprognostic (8.48e-2)" 5.5 1.0 0.3 0.7 0.8 0.4 2.6 1.0 0.9 1.9 0.2 1.3 17.4 0.8 0.1 1.5 0.7 0.0 8.4 0.3 0.6 0.9 2.6 0.7 1.4 2.8 1.3 19.7 45360.2 0.0 1.4 3.2 2.5 1.5 0.4 0.8 7.8 0.0 0.8 1.1 30.6 0.0 1.2 1.2 108.9 2.2 1.1 0.1 0.6 0.0 0.0 0.5 0.8 3.1 0.0 0.0 0.4 2.2 0.0 0.0 0.0 0.0 0.0 0.3 0.0 3.8 0.0 0.0 0.5 0.0 0.3 0.0 0.7 0.0 0.0 0.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.2 0.0 3.0 0.0 0.0 0.3 1.6 0.0 0.1 0.0 1.0 0.1 0.0 0.1 0.0 0.0 0.6 0.4 0.3 0.0 0.4 0.1 0.4 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.8 1.0 0.9 0.3 0.6 2.8 1.3 2.5 1.2 1.1 3.1 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.3 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.6 1.9 8.1 4.3 0.0 0.0 0.9 0.0 0.0 0.1 4973.8 0.0 0.2 4.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.5 0.0 0.0 0.0 10.5 0.3 0.5 0.0 0.0 13.9 4.6 0.0 0.5 1.0 471.3 52.9 0.0 0.0 0.0 9.9 0.0 0.0 0.3 0.0 0.0 1.3 0.4 2.0 0.0 0.1 0.3 0.0 0.2 1.5 0.2 CPA3 ENSG00000163751 "Carboxypeptidase A3" P15088 3 148865296-148897203 "Enzymes, Metabolic proteins, Plasma proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 112.0;lung: 86.3" "Cell type enriched" "Detected in some" 26 "granulocytes: 4422.8" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 1534 "basophil: 1115.4" "Lineage enriched" "Detected in single" 5518 "granulocytes: 1115.4" "Cell line enriched" "Detected in some" 45 "HEL: 303.3" "Not detected" "Not detected" "HPA006479, HPA008689, CAB020712" Enhanced Approved "Nucleoplasm,Golgi apparatus" "Secreted to blood" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 36: HEL - Hemostasis" "Cluster 60: Granulocytes - Receptor signaling" "Golgi apparatus" Nucleoplasm "CAB020712: , HPA006479: AB_1078396, HPA008689: AB_1846009" "unprognostic (1.07e-1)" "unprognostic (3.03e-2)" "unprognostic (2.66e-3)" "unprognostic (9.13e-3)" "unprognostic (3.50e-1)" "unprognostic (1.18e-3)" "unprognostic (2.47e-1)" "unprognostic (1.57e-2)" "unprognostic (2.14e-1)" "unprognostic (9.51e-2)" "unprognostic (1.89e-1)" "unprognostic (5.30e-3)" "unprognostic (3.50e-3)" "unprognostic (5.18e-3)" "unprognostic (3.24e-2)" "unprognostic (1.74e-1)" "unprognostic (1.69e-3)" 18.2 2.6 0.0 19.9 0.4 25.7 20.9 0.0 0.0 59.4 0.3 39.2 27.3 26.1 19.3 41.1 6.6 112.0 6.2 0.0 0.0 3.3 2.7 86.3 11.2 0.0 0.0 0.9 21.0 2.8 0.9 1.7 0.0 18.5 56.6 0.0 12.1 15.1 1.6 17.7 45.9 25.7 0.0 1.1 45.3 3.8 0.0 14.9 0.9 10.2 15.1 54.0 10.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 2.6 4.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.7 0.0 0.0 303.3 0.0 0.0 0.2 0.2 6.7 0.2 0.0 0.1 0.3 0.5 3.8 0.0 0.1 0.0 1.8 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1115.4 0.0 0.7 0.0 0.1 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.1 0.4 0.0 0.2 0.0 0.0 2.9 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 32.1 163.9 0.0 0.5 1.7 0.4 0.0 0.0 0.0 0.0 0.0 0.3 0.0 17.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 3.7 0.0 16.0 0.0 1.6 0.0 3.5 0.5 0.0 4422.8 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 5.0 1.8 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 6.7 0.3 0.0 0.0 8.7 0.0 0.0 0.2 0.3 0.0 0.0 0.0 1.3 0.0 41.7 0.0 0.0 0.3 CPA4 CPA3 ENSG00000128510 "Carboxypeptidase A4" Q9UI42 7 130293134-130324180 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 21.6;skin 1: 57.1" "Cell type enhanced" "Detected in some" "Basal keratinocytes: 17.7;Basal respiratory cells: 23.7;Exocrine glandular cells: 54.1;Fibroblasts: 11.5;Suprabasal keratinocytes: 31.0" "Cancer enhanced" "Detected in many" "cervical cancer: 10.0;head and neck cancer: 9.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ hTERT+: 140.1;hTERT-RPE1: 261.0;LHCN-M2: 284.2;U-2 OS: 151.0;U-87 MG: 272.7" "Not detected" "Not detected" "Not detected" "Not detected" HPA021030 Approved Nucleoplasm,Centrosome,Cytosol "Secreted in other tissues" NA Yes 390000 "Cluster 31: Skin - Epidermis development" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 1: Pancreatic cells - Digestion" Nucleoplasm "Centrosome, Cytosol" "HPA021030: AB_1846010" "unprognostic (7.60e-3)" "unprognostic (4.00e-2)" "unprognostic (1.59e-3)" "unprognostic (3.63e-3)" "unprognostic (2.24e-2)" "unprognostic (2.91e-2)" "unprognostic (2.78e-2)" "unprognostic (4.36e-3)" "unprognostic (3.23e-1)" "unprognostic (5.79e-2)" "unprognostic (2.37e-3)" "unprognostic (6.49e-2)" "unprognostic (6.21e-10)" "unprognostic (2.39e-1)" "unprognostic (1.67e-1)" "unprognostic (7.56e-2)" "prognostic unfavorable (1.31e-4)" 5.0 4.4 0.4 0.4 0.4 0.1 3.5 0.5 1.7 15.3 0.5 0.0 0.0 0.2 0.3 21.6 0.4 0.1 1.1 0.6 2.1 0.6 0.1 0.4 0.2 1.1 0.7 0.1 12.7 0.0 0.5 2.0 1.1 0.2 0.0 0.2 6.7 0.0 0.3 57.1 0.2 0.8 0.6 3.3 0.4 0.3 1.2 0.8 0.0 0.0 0.9 0.0 12.6 1.1 95.3 5.0 0.3 0.3 0.7 1.5 0.1 74.6 140.1 74.9 18.5 0.7 8.1 0.1 14.3 31.9 75.2 5.5 0.0 41.3 76.7 0.4 0.3 0.0 33.3 2.1 1.8 0.3 0.2 1.0 65.2 6.7 9.4 261.0 0.3 0.1 0.0 0.2 284.2 0.2 0.0 0.0 0.8 0.4 11.1 0.3 75.4 0.1 34.5 4.0 0.2 0.0 49.9 23.3 0.5 28.0 0.5 0.4 57.3 18.1 151.0 6.2 7.4 0.2 0.2 0.1 272.7 0.1 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.4 0.4 0.5 1.7 0.6 2.1 1.1 0.7 1.1 0.6 1.2 1.1 0.0 3.2 0.5 0.0 0.0 17.7 0.5 23.7 0.6 0.0 4.2 2.8 0.3 0.0 8.5 0.0 0.0 5.6 0.1 0.0 0.0 0.5 0.4 0.4 0.2 0.3 0.0 0.0 0.4 54.1 1.2 11.5 0.0 2.0 0.0 0.0 0.7 0.0 0.1 0.0 0.1 0.0 0.0 0.0 1.2 0.2 0.0 0.3 3.6 1.0 0.6 0.0 0.0 0.0 0.5 7.9 0.0 0.0 0.0 0.9 0.0 0.1 2.9 0.0 0.0 1.3 0.4 0.1 0.7 10.0 31.0 9.4 0.1 0.0 0.0 1.6 CPA5 ENSG00000158525 "Carboxypeptidase A5" Q8WXQ8 7 130344816-130368730 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 15 "testis: 33.6" "Group enriched" "Detected in some" 23 "Early spermatids: 76.1;Late spermatids: 144.1" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Group enriched" "Detected in some" 4 "memory CD4 T-cell: 16.8;naive CD8 T-cell: 42.5;T-reg: 56.4" "Lineage enriched" "Detected in single" 102 "T-cells: 56.4" "Cell line enhanced" "Detected in some" "RH-30: 7.3;RT4: 3.4;U-266/84: 6.0" "Not detected" "Not detected" HPA020322 Approved Nucleoplasm "Secreted in male reproductive system" NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 83: Testis - Spermatogenesis" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "HPA020322: AB_10960562" "unprognostic (2.44e-1)" "unprognostic (3.76e-1)" "unprognostic (1.50e-1)" "unprognostic (5.94e-2)" "unprognostic (4.96e-2)" "unprognostic (7.10e-3)" "unprognostic (1.64e-2)" "unprognostic (1.41e-2)" "unprognostic (3.26e-1)" "unprognostic (5.02e-2)" "unprognostic (5.83e-4)" "unprognostic (1.43e-1)" "unprognostic (8.88e-13)" "unprognostic (5.16e-2)" "unprognostic (1.32e-1)" "unprognostic (8.81e-2)" "unprognostic (3.08e-2)" 0.3 0.2 0.3 0.1 0.2 0.2 0.1 0.2 1.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.5 0.2 0.0 0.0 1.9 0.3 0.4 0.0 0.5 0.0 1.2 0.6 0.4 0.1 0.0 0.0 0.0 0.0 0.2 1.0 0.7 0.0 0.2 1.8 0.0 33.6 0.5 2.2 0.3 0.0 0.9 0.6 0.0 0.4 0.5 0.0 0.0 0.4 0.0 0.0 0.0 0.3 2.1 0.1 0.2 1.6 0.0 0.0 0.0 0.0 0.7 0.0 0.2 0.4 0.0 0.0 1.2 0.5 0.5 0.8 0.3 0.0 0.0 0.0 0.7 0.0 0.9 0.9 0.0 0.6 0.0 1.0 0.0 0.0 0.3 0.0 0.4 0.0 0.0 0.0 7.3 0.2 1.0 3.4 0.9 0.1 0.0 2.0 0.0 0.1 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 6.0 0.0 0.3 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.6 0.0 16.8 8.6 0.0 0.0 4.2 42.5 0.0 0.0 0.0 0.0 56.4 5.8 0.3 0.2 0.2 1.0 0.4 0.5 0.3 0.4 0.4 0.2 0.5 0.4 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.8 0.6 0.3 0.0 0.0 1.8 0.0 3.1 0.0 0.0 0.0 0.1 76.1 0.2 0.0 0.1 0.0 0.0 0.1 0.2 0.2 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 144.1 0.9 0.1 0.0 0.0 0.9 0.0 2.1 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.1 0.0 0.0 0.0 2.1 0.0 3.8 2.6 0.0 0.0 4.7 4.0 0.0 0.0 0.1 CPA6 CPAH ENSG00000165078 "Carboxypeptidase A6" Q8N4T0 8 67422038-67746378 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 2.3;prostate: 2.7;retina: 2.2" "Cell type enhanced" "Detected in some" "Basal prostatic cells: 31.7;Early spermatids: 21.7;Microglial cells: 12.2;Muller glia cells: 22.5;Pancreatic endocrine cells: 21.5;Paneth cells: 12.8;Prostatic glandular cells: 11.3;Urothelial cells: 36.6" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CACO-2: 2.5;EFO-21: 1.5;Hep G2: 3.4;OE19: 1.5" "Region enriched" "Detected in some" 9 "olfactory bulb: 12.6" "Low region specificity" "Detected in all" "Secreted to extracellular matrix" NA NA "Cluster 37: Intestine - Unknown function" "Cluster 39: CACO-2 - Unknown function" "Cluster 22: Epithelial cell types - Mixed function" "unprognostic (2.85e-2)" "unprognostic (1.95e-1)" "unprognostic (1.72e-2)" "unprognostic (1.14e-1)" "unprognostic (2.58e-1)" "unprognostic (2.24e-1)" "unprognostic (2.08e-1)" "unprognostic (2.88e-1)" "unprognostic (9.35e-2)" "unprognostic (1.65e-1)" "unprognostic (5.23e-2)" "unprognostic (6.99e-2)" "unprognostic (3.57e-4)" "unprognostic (9.61e-5)" "unprognostic (1.75e-1)" "unprognostic (9.09e-2)" "unprognostic (1.41e-2)" 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.6 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 2.3 2.2 0.0 0.2 0.0 0.0 0.2 0.8 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.0 1.2 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 1.5 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.0 31.7 0.0 5.7 0.2 0.1 0.4 0.2 0.0 0.1 0.0 0.0 0.0 0.0 2.3 0.0 0.0 21.7 0.1 0.0 0.1 2.4 0.0 1.6 0.4 0.0 0.4 0.0 0.7 0.0 0.0 0.0 0.0 0.1 1.7 1.3 2.2 0.0 0.0 0.0 3.2 1.8 0.2 0.0 12.2 0.1 22.5 0.0 3.0 1.3 21.5 12.8 0.0 0.0 11.3 0.0 0.0 0.0 1.0 0.0 0.1 0.3 0.0 0.0 0.8 0.0 0.0 0.6 0.0 5.7 36.6 CPB1 ENSG00000153002 "Carboxypeptidase B1" P15086 3 148791102-148860187 "Enzymes, Plasma proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 1970 "pancreas: 226925.8" "Cell type enriched" "Detected in some" 12 "Exocrine glandular cells: 7306.0" "Group enriched" "Detected in some" 312 "breast cancer: 293.8;pancreatic cancer: 641.4" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "basophil: 4.0" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "HDLM-2: 1.0;U-2 OS: 1.8" "Not detected" "Not detected" "Not detected" "Not detected" "CAB026158, HPA038069, HPA046340" Enhanced "Secreted to digestive system" NA NA 88000000 "Cluster 17: Basophils - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 9: U-2 OS - Unknown function" "Cluster 1: Pancreatic cells - Digestion" "CAB026158: , HPA038069: AB_2675816, HPA046340: AB_2679628" "unprognostic (6.90e-2)" "unprognostic (3.79e-2)" "unprognostic (3.34e-2)" "unprognostic (2.64e-2)" "unprognostic (5.58e-2)" "unprognostic (3.27e-2)" "unprognostic (6.26e-4)" "unprognostic (1.90e-1)" "unprognostic (1.82e-1)" "unprognostic (1.07e-1)" "unprognostic (7.59e-2)" "unprognostic (4.51e-2)" "unprognostic (5.50e-8)" "unprognostic (3.08e-1)" "unprognostic (1.60e-1)" "unprognostic (4.93e-2)" 15.7 83.0 0.4 5.1 1.7 2.5 78.3 0.6 1.4 6.0 0.1 2.6 31.2 4.7 0.3 3.5 1.8 0.1 40.8 0.6 0.8 2.0 7.1 1.7 8.1 1.0 1.2 115.1 226925.8 0.0 2.1 13.7 1.1 4.7 4.5 0.0 36.3 0.0 2.2 2.8 17.2 0.0 0.4 19.2 28.3 2.9 1.2 0.1 1.6 0.0 0.0 1.4 2.0 3.3 0.0 0.0 0.0 0.0 0.9 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.9 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.5 0.0 0.9 0.2 0.0 0.0 0.0 4.0 0.3 0.5 1.3 0.4 0.9 0.4 0.5 1.1 0.1 0.7 0.3 1.4 1.9 1.4 0.5 0.5 0.3 0.4 0.4 1.7 0.6 1.4 0.6 0.8 1.0 1.2 1.1 0.4 1.2 3.3 2.2 0.0 0.0 1.0 0.0 0.6 0.5 0.0 0.0 0.0 8.7 1.9 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 11.6 11.2 0.0 0.1 1.1 164.9 1.3 0.3 7306.0 0.0 36.8 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.2 0.2 0.0 0.0 1.0 2.5 0.6 1.5 0.0 0.0 18.1 0.0 0.0 0.0 29.8 590.0 0.1 0.0 0.0 4.6 0.0 0.0 0.0 0.0 0.0 4.2 2.5 0.0 1.1 0.1 0.3 0.3 0.3 1.1 0.2 0.2 CPB2 "CPU, PCPB, TAFI" ENSG00000080618 "Carboxypeptidase B2" Q96IY4 13 46053186-46105033 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Blood coagulation, Fibrinolysis, Hemostasis" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 84 "liver: 1484.1" "Cell type enriched" "Detected in some" 7 "Hepatocytes: 1332.7" "Cancer enriched" "Detected in some" 112 "liver cancer: 268.4" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 86 "Hep G2: 173.2" "Not detected" "Not detected" "Not detected" "Not detected" HPA004146 Approved "Secreted to blood" NA NA 8500000000 "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" "HPA004146: AB_1078397" "unprognostic (3.44e-2)" "unprognostic (1.25e-1)" "unprognostic (2.94e-2)" "unprognostic (1.89e-2)" "unprognostic (7.69e-2)" "unprognostic (1.17e-2)" "prognostic favorable (2.06e-4)" "unprognostic (1.89e-1)" "unprognostic (2.74e-1)" "unprognostic (2.48e-1)" "unprognostic (3.17e-2)" "unprognostic (4.83e-2)" "unprognostic (3.20e-3)" "unprognostic (1.34e-1)" "unprognostic (7.10e-2)" "unprognostic (3.34e-2)" "unprognostic (9.61e-2)" 0.1 0.0 0.5 0.1 3.1 0.7 0.1 0.6 1.8 0.0 0.0 0.0 0.0 0.0 6.3 0.0 0.0 4.8 0.0 0.5 1.4 0.4 1484.1 17.6 0.1 1.7 2.0 0.0 0.5 0.0 0.0 0.0 2.5 0.1 0.0 0.4 0.1 0.2 0.2 0.1 0.1 0.0 0.3 0.4 0.1 0.2 2.2 0.0 0.1 0.0 0.0 0.0 0.0 5.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.3 0.0 0.6 0.3 173.2 0.0 0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.2 0.2 0.0 0.1 0.2 0.2 0.2 0.0 0.0 0.0 0.5 0.2 0.0 0.1 0.0 0.1 0.1 0.0 2.0 0.1 0.1 0.1 0.0 0.1 0.1 0.0 0.0 0.2 0.5 0.3 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.5 3.1 0.6 1.8 0.5 1.4 1.7 2.0 2.5 0.3 2.2 5.1 0.0 3.2 27.0 3.9 1.7 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.1 190.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.3 0.1 1.0 0.0 10.7 4.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 15.7 1332.7 0.1 0.0 5.3 0.0 0.0 22.7 0.0 0.1 0.0 0.0 0.0 1.0 0.0 0.0 0.0 13.0 36.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 CPD GP180 ENSG00000108582 "Carboxypeptidase D" O75976 17 30378927-30469989 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 25.0" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA052796, HPA055465" Approved Approved "Nucleoplasm,Nuclear membrane,Nuclear speckles" NA NA 1700000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 1: Thyroid gland - Transcription" "Cluster 21: OE19 - Mitochondria" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Nucleoplasm, Nuclear speckles" "Nuclear membrane" "HPA052796: AB_2681953, HPA055465: AB_2682823" "unprognostic (1.05e-1)" "unprognostic (1.31e-1)" "unprognostic (3.05e-2)" "unprognostic (3.62e-2)" "unprognostic (6.13e-2)" "unprognostic (1.65e-1)" "unprognostic (7.97e-3)" "unprognostic (4.45e-2)" "unprognostic (2.07e-2)" "unprognostic (2.96e-1)" "unprognostic (1.62e-1)" "unprognostic (3.16e-1)" "unprognostic (1.58e-1)" "unprognostic (3.74e-2)" "unprognostic (7.25e-2)" "unprognostic (3.36e-1)" "unprognostic (1.08e-1)" 25.9 7.4 10.8 19.7 13.1 32.2 20.5 15.4 25.6 40.9 9.4 18.0 20.3 15.8 13.2 12.1 23.0 31.8 9.1 11.8 13.0 19.7 25.4 18.2 7.9 19.5 13.3 7.8 15.7 28.5 6.1 30.3 17.8 16.8 20.1 14.9 44.8 11.2 8.1 8.2 19.8 23.3 18.3 9.3 37.3 41.3 13.5 8.3 57.6 14.0 9.9 18.3 7.1 28.0 39.4 58.9 50.0 51.6 51.0 95.9 18.0 53.1 77.2 36.0 43.9 69.6 24.9 5.1 65.8 61.3 45.6 27.6 32.7 67.1 60.3 18.7 46.7 11.2 32.5 43.2 61.8 73.8 28.3 172.3 29.4 46.2 44.3 59.7 74.3 16.5 22.1 56.1 29.2 7.7 23.9 20.3 14.1 89.8 13.4 22.6 57.8 15.3 67.3 44.2 12.5 31.5 63.4 54.0 27.6 58.0 51.2 50.4 89.2 35.7 23.3 56.2 51.3 22.5 50.0 16.1 45.6 47.2 30.9 4.5 7.7 8.4 4.1 3.6 4.5 0.2 2.1 3.5 4.4 0.4 1.6 2.0 25.0 2.7 3.2 0.5 1.5 3.6 10.8 13.1 15.4 25.6 11.8 13.0 19.5 13.3 17.8 18.3 13.5 28.0 124.4 32.1 23.9 28.4 7.5 22.0 34.2 99.2 21.6 30.8 34.9 18.8 13.7 155.8 129.5 29.5 45.9 24.8 35.9 37.8 1.9 32.4 96.1 21.9 24.9 51.9 32.3 15.6 62.9 24.8 11.1 25.6 72.4 35.2 24.1 21.6 56.0 93.9 15.9 47.1 57.1 69.0 85.5 31.2 20.4 56.0 16.8 33.7 30.2 90.9 32.9 13.4 29.9 45.8 164.5 32.8 26.4 16.1 38.1 58.5 50.1 18.5 84.2 33.8 0.0 21.3 23.4 31.0 21.0 21.1 18.6 24.1 35.6 14.2 34.4 50.7 CPE ENSG00000109472 "Carboxypeptidase E" P16870 4 165361194-165498547 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 643.3;retina: 741.7" "Cell type enhanced" "Detected in many" "Astrocytes: 727.4;Bipolar cells: 569.1;Cone photoreceptor cells: 621.3;Enteroendocrine cells: 587.4;Leydig cells: 500.8;Muller glia cells: 530.9;Peritubular cells: 621.0;Rod photoreceptor cells: 803.3;Sertoli cells: 854.6;Smooth muscle cells: 519.4" "Cancer enhanced" "Detected in all" "glioma: 240.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "Hep G2: 311.6;SCLC-21H: 418.2;SiHa: 629.0;SuSa: 342.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003819, CAB024907" Supported Approved Nucleoplasm,Vesicles,Centrosome "Intracellular and membrane" NA NA 600000 "Cluster 77: Retina - Visual perception" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 48: Smooth muscle cells - ECM organization" Centrosome "Nucleoplasm, Vesicles" "CAB024907: , HPA003819: AB_2667054" "unprognostic (1.84e-1)" "unprognostic (5.64e-3)" "unprognostic (1.61e-1)" "unprognostic (1.70e-2)" "unprognostic (2.51e-1)" "unprognostic (1.44e-2)" "unprognostic (1.65e-1)" "unprognostic (9.52e-2)" "unprognostic (2.91e-3)" "unprognostic (9.01e-2)" "unprognostic (4.84e-3)" "unprognostic (5.56e-3)" "prognostic unfavorable (2.60e-4)" "unprognostic (4.35e-3)" "unprognostic (1.46e-1)" "unprognostic (2.26e-1)" "prognostic unfavorable (2.12e-4)" 138.1 151.7 554.8 20.5 593.0 1.8 97.5 550.9 604.0 53.9 311.9 44.6 22.0 67.7 404.6 74.8 88.6 65.7 100.7 584.3 643.3 68.4 26.7 50.1 37.5 417.0 494.2 104.0 170.4 89.9 328.4 7.7 456.2 295.1 36.8 741.7 104.5 84.7 56.2 45.1 30.7 83.3 448.3 11.6 80.2 146.2 578.2 68.8 179.7 47.5 35.2 33.8 73.4 446.2 0.2 8.4 54.4 10.5 41.4 4.5 2.4 0.1 21.5 8.1 16.5 0.0 0.5 0.0 15.8 0.6 1.9 1.2 20.4 4.4 4.7 0.3 78.6 0.0 21.6 311.6 3.0 0.3 0.5 102.3 21.5 0.3 0.4 104.0 0.2 0.0 0.1 2.1 11.2 15.4 0.4 2.7 34.4 0.2 12.1 0.3 0.2 1.1 0.7 3.4 418.2 138.0 629.0 77.9 0.0 342.6 46.7 1.9 0.0 16.7 42.5 1.5 1.5 23.5 0.6 2.2 15.5 0.7 5.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 554.8 593.0 550.9 604.0 584.3 643.3 417.0 494.2 456.2 448.3 578.2 446.2 87.1 0.0 5.6 727.4 0.6 26.1 81.7 10.3 66.0 569.1 25.6 52.1 54.5 54.3 5.0 22.0 621.3 0.6 1.4 2.9 0.0 19.7 6.7 2.2 12.1 130.4 587.4 2.7 234.8 1.8 0.3 249.0 31.6 1.3 0.0 8.6 274.2 15.1 1.0 70.7 129.0 16.2 38.7 5.4 41.2 23.3 500.8 6.3 87.2 94.6 1.0 530.9 0.0 211.6 23.0 12.4 3.7 621.0 0.7 434.6 10.2 12.7 1.2 803.3 854.6 14.1 519.4 19.7 13.3 14.0 20.9 0.8 5.5 15.4 4.0 18.9 CPM ENSG00000135678 "Carboxypeptidase M" P14384 12 68842197-68971570 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 156.1" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 359.0;Alveolar cells type 2: 362.2;Kupffer cells: 368.5;Sertoli cells: 762.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "classical monocyte: 21.0;intermediate monocyte: 14.5;myeloid DC: 16.6;non-classical monocyte: 7.4" "Group enriched" "Detected in many" 5 "dendritic cells: 16.6;monocytes: 21.0" "Group enriched" "Detected in many" 4 "ASC diff: 71.1;ASC TERT1: 50.0;HSkMC: 91.2;SiHa: 68.9;THP-1: 26.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002657, HPA077243" Enhanced Uncertain Vesicles NA NA 7100000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 82: Adipose tissue - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 4: Macrophages - Innate immune response" Vesicles "HPA002657: AB_1078398, HPA077243: " "unprognostic (1.74e-1)" "unprognostic (3.11e-1)" "unprognostic (2.88e-3)" "prognostic favorable (1.00e-4)" "unprognostic (4.58e-2)" "unprognostic (8.61e-2)" "unprognostic (1.57e-2)" "unprognostic (2.01e-1)" "unprognostic (8.42e-2)" "unprognostic (1.40e-1)" "unprognostic (1.35e-1)" "unprognostic (1.42e-1)" "unprognostic (1.47e-3)" "unprognostic (8.58e-2)" "unprognostic (6.85e-2)" "unprognostic (2.59e-2)" "unprognostic (1.06e-1)" 156.1 11.5 6.4 14.4 13.3 3.5 40.2 10.1 10.5 14.4 3.8 33.5 4.4 23.9 0.9 10.1 16.2 16.1 4.6 7.6 10.2 41.3 26.5 59.3 16.1 19.3 11.5 18.0 13.0 12.0 1.0 70.1 11.9 14.7 26.6 6.7 4.1 2.8 5.8 21.7 5.9 6.4 7.5 19.4 15.3 5.4 28.0 4.3 7.5 9.7 10.5 9.3 5.7 23.5 0.1 4.0 0.1 0.0 71.1 50.0 0.7 9.8 1.1 1.7 2.3 3.2 4.1 0.5 9.6 1.4 4.1 0.0 1.4 2.7 4.1 0.1 2.7 0.0 15.1 0.3 0.4 1.2 1.9 91.2 0.6 1.0 2.0 8.6 0.0 0.3 0.0 0.1 7.3 1.7 0.0 0.7 1.7 0.0 5.2 3.1 0.6 0.0 7.2 5.9 0.4 0.2 68.9 10.7 7.9 5.5 1.2 26.5 0.2 1.2 7.5 0.5 0.2 0.4 0.5 13.1 4.3 13.1 5.9 0.6 21.0 0.1 0.2 14.5 0.0 1.8 1.5 0.1 16.6 3.5 0.9 0.2 1.6 0.5 7.4 1.1 1.9 7.3 6.4 13.3 10.1 10.5 7.6 10.2 19.3 11.5 11.9 7.5 28.0 23.5 83.3 359.0 362.2 34.6 4.9 12.4 3.5 6.1 0.6 3.3 7.8 8.9 2.6 135.8 70.1 51.5 0.0 32.3 1.1 97.5 29.4 57.9 16.6 100.9 8.3 29.0 10.8 3.6 1.2 212.5 59.9 14.1 4.6 237.1 112.5 6.7 73.9 36.6 134.6 0.0 1.3 28.7 0.0 368.5 36.3 17.5 105.0 202.2 10.6 19.7 23.3 68.9 1.0 23.1 161.8 68.0 65.9 79.0 2.4 38.7 1.9 63.7 16.4 5.7 762.6 7.2 126.9 0.6 3.9 2.4 9.9 172.4 14.5 46.3 32.7 2.8 CPN1 ENSG00000120054 "Carboxypeptidase N subunit 1" P15169 10 100042193-100081869 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 54 "liver: 81.6" "Cell type enriched" "Detected in some" 4 "Hepatocytes: 37.2" "Group enriched" "Detected in some" 12 "liver cancer: 26.6;melanoma: 7.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 17 "SK-MEL-30: 141.8" "Low region specificity" "Detected in some" "Not detected" "Not detected" "Secreted to blood" NA NA 13000000000 "Cluster 62: Liver - Hemostasis" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 15: Hepatocytes - Hemostasis" "unprognostic (2.97e-2)" "unprognostic (2.23e-2)" "unprognostic (3.93e-2)" "unprognostic (1.64e-1)" "unprognostic (6.75e-2)" "unprognostic (2.93e-2)" "unprognostic (5.26e-2)" "unprognostic (2.63e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 81.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 141.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 37.2 0.0 0.0 0.4 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 7.6 4.4 0.0 0.0 0.1 0.1 0.0 0.2 0.0 CPO ENSG00000144410 "Carboxypeptidase O" Q8IVL8 2 206939518-206969474 "Enzymes, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 15 "intestine: 111.8" "Cell type enriched" "Detected in some" 8 "Proximal enterocytes: 349.9" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 30 "basophil: 12.0" "Lineage enriched" "Detected in single" 84 "granulocytes: 12.0" "Cell line enhanced" "Detected in single" "NB-4: 1.0" "Not detected" "Not detected" "Intracellular and membrane" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 56: Intestine - Transmembrane transport" "Cluster 24: NB-4 - Immune response" "Cluster 45: Enterocytes - Digestion" "unprognostic (9.39e-2)" "unprognostic (2.64e-1)" "unprognostic (2.95e-2)" "unprognostic (5.21e-2)" "unprognostic (2.28e-1)" "unprognostic (1.27e-2)" "unprognostic (1.16e-1)" "unprognostic (9.06e-2)" "unprognostic (4.03e-1)" "unprognostic (1.33e-1)" "unprognostic (3.75e-3)" "unprognostic (1.22e-1)" "unprognostic (3.60e-2)" "unprognostic (2.52e-1)" "unprognostic (6.56e-2)" "unprognostic (4.03e-2)" "unprognostic (4.89e-2)" 0.7 1.0 2.4 0.1 2.4 0.0 0.8 1.3 3.1 0.5 1.2 1.2 0.5 0.3 7.5 0.2 0.7 0.4 0.4 2.2 2.3 1.3 0.7 0.3 0.1 2.0 2.1 0.4 0.5 1.0 1.2 0.2 2.3 0.9 0.4 0.6 0.8 0.8 0.7 0.5 111.8 0.7 2.1 0.2 0.5 0.8 2.4 0.1 1.0 0.5 0.1 0.5 0.3 3.3 0.0 0.0 0.0 0.0 0.7 0.2 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.6 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.2 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.1 12.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 2.4 1.3 3.1 2.2 2.3 2.0 2.1 2.3 2.1 2.4 3.3 0.1 0.0 0.0 9.1 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.1 0.2 0.0 0.0 0.0 43.6 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 35.9 6.3 0.0 0.0 0.0 0.7 0.3 0.0 0.0 6.5 0.0 0.0 0.0 2.0 14.6 0.0 3.8 0.0 0.0 0.0 349.9 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.1 CPQ "LDP, PGCP" ENSG00000104324 "Carboxypeptidase Q" Q9Y646 8 96645242-97149654 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "thyroid gland: 225.9" "Cell type enhanced" "Detected in all" "Astrocytes: 150.2;Oligodendrocytes: 299.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 250.5" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC diff: 116.1;ASC TERT1: 131.4;hTERT-RPE1: 108.2;Karpas-707: 97.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023235, HPA024490" Enhanced Supported "Golgi apparatus,Vesicles" "Secreted to blood" NA NA 51000000 "Cluster 50: Neutrophils - Cellular senescence" "Cluster 1: Thyroid gland - Transcription" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Golgi apparatus, Vesicles" "HPA023235: AB_1855257, HPA024490: AB_1855258" "unprognostic (4.04e-2)" "unprognostic (5.46e-2)" "unprognostic (4.45e-2)" "unprognostic (1.68e-1)" "unprognostic (1.51e-3)" "unprognostic (3.98e-3)" "unprognostic (5.24e-2)" "unprognostic (2.92e-2)" "unprognostic (2.67e-2)" "unprognostic (9.19e-2)" "unprognostic (2.38e-3)" "unprognostic (6.16e-3)" "prognostic favorable (5.40e-5)" "unprognostic (6.74e-3)" "unprognostic (8.71e-2)" "unprognostic (3.21e-2)" "unprognostic (1.75e-1)" 46.2 35.9 22.6 25.4 33.9 31.8 34.7 28.0 26.7 75.1 20.6 39.6 29.3 46.0 36.2 25.9 39.8 57.8 51.8 21.6 27.0 80.5 70.0 32.3 22.8 32.6 27.5 87.4 46.7 60.7 25.6 39.2 33.2 40.2 33.1 16.8 32.8 54.2 13.3 20.6 35.0 64.7 25.9 31.3 32.1 13.9 30.3 8.2 225.9 33.2 17.0 46.3 38.6 38.6 0.6 2.1 2.1 0.1 116.1 131.4 0.5 35.3 55.6 12.8 26.5 2.0 0.9 0.4 27.2 59.0 15.7 1.0 2.4 2.8 12.0 31.4 4.4 28.4 1.5 17.7 25.6 4.9 37.0 69.6 6.5 15.0 3.7 108.2 6.0 0.1 27.1 97.0 29.4 1.2 0.5 14.1 2.5 0.2 5.2 4.3 0.0 0.6 26.7 13.2 2.4 0.3 10.2 0.4 28.2 25.8 12.3 28.6 21.3 51.9 4.9 0.8 11.5 7.9 0.9 0.3 32.2 21.6 33.5 32.0 71.3 45.1 27.3 49.6 27.6 5.4 20.3 24.0 51.8 7.4 17.6 24.6 250.5 25.9 47.5 14.8 22.2 40.6 22.6 33.9 28.0 26.7 21.6 27.0 32.6 27.5 33.2 25.9 30.3 38.6 46.6 12.8 12.5 150.2 11.7 19.4 25.7 21.3 9.6 12.7 12.1 27.9 27.2 42.9 13.9 47.8 29.2 12.1 40.8 9.3 17.6 22.7 5.0 6.6 43.3 27.1 13.8 7.2 24.0 10.7 1.8 123.8 10.7 8.6 38.0 43.1 51.0 48.3 54.0 10.1 31.3 7.9 24.4 56.0 44.9 9.0 72.4 39.4 78.2 131.2 33.7 43.4 39.1 44.7 299.6 11.7 9.5 73.0 11.9 12.4 42.4 56.0 9.7 16.3 52.6 71.1 67.8 5.6 3.4 2.8 13.1 6.0 23.8 38.6 12.2 13.5 CPVL ENSG00000106066 "Carboxypeptidase vitellogenic like" Q9H3G5 7 28995235-29195451 "Enzymes, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 219.0" "Cell type enhanced" "Detected in many" "Hofbauer cells: 306.1;Kupffer cells: 290.3;Langerhans cells: 531.0;Macrophages: 266.2;monocytes: 176.8" "Cancer enhanced" "Detected in all" "thyroid cancer: 61.9" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "classical monocyte: 1136.9;intermediate monocyte: 953.5;myeloid DC: 1319.5" "Group enriched" "Detected in all" 52 "dendritic cells: 1319.5;monocytes: 1136.9" "Cell line enhanced" "Detected in many" "BEWO: 190.8;RPTEC TERT1: 801.1;U-266/84: 205.5" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB003697, HPA045715, HPA056466" Enhanced Approved "Endoplasmic reticulum" "Intracellular and membrane" NA NA 760000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 2: Immune cells - Immune response" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 41: Macrophages - Immune response" "Endoplasmic reticulum" "CAB003697: AB_425990, HPA045715: AB_2679429, HPA056466: AB_2683140" "unprognostic (4.72e-2)" "unprognostic (7.08e-2)" "unprognostic (5.96e-2)" "prognostic unfavorable (8.56e-6)" "unprognostic (1.63e-1)" "unprognostic (2.49e-2)" "unprognostic (6.85e-3)" "unprognostic (7.01e-2)" "unprognostic (1.49e-1)" "unprognostic (4.98e-2)" "unprognostic (3.07e-1)" "unprognostic (4.25e-2)" "unprognostic (1.56e-2)" "unprognostic (1.79e-3)" "unprognostic (2.21e-1)" "unprognostic (7.46e-3)" "prognostic unfavorable (4.99e-4)" 44.0 23.5 7.5 66.3 8.7 59.8 24.9 48.9 12.0 28.5 39.6 28.9 32.8 17.1 34.6 25.4 19.8 42.1 79.3 6.8 9.9 96.7 52.9 57.6 92.9 15.2 11.4 18.1 7.9 5.4 10.1 84.9 15.4 17.9 25.7 0.9 5.3 21.3 12.5 19.3 46.5 34.1 11.8 219.0 15.5 34.4 8.8 66.7 128.4 8.3 35.8 50.6 15.8 23.4 1.5 0.2 20.3 0.1 0.1 0.0 190.8 0.0 0.0 1.9 0.4 59.8 0.1 0.0 90.3 0.8 94.4 3.2 51.8 4.2 0.6 0.4 47.9 67.0 1.2 144.5 0.0 0.0 0.3 0.3 5.9 0.7 1.6 0.0 0.6 27.5 45.5 0.1 1.6 0.0 63.4 0.4 31.6 0.1 16.0 0.3 0.0 0.6 801.1 22.8 11.9 9.4 53.6 125.5 101.7 97.0 15.1 49.6 0.0 0.4 0.8 0.5 12.0 17.5 205.5 1.0 0.2 25.0 20.8 19.5 1136.9 5.7 2.6 953.5 3.4 1.8 1.3 1.9 1319.5 1.2 1.2 1.2 23.4 5.8 327.8 34.8 1.5 1142.7 7.5 8.7 48.9 12.0 6.8 9.9 15.2 11.4 15.4 11.8 8.8 23.4 12.3 6.4 16.0 3.3 7.2 12.5 1.3 0.7 5.7 0.0 2.6 3.4 69.1 10.0 2.5 71.7 0.0 138.0 2.1 0.2 35.2 0.5 24.7 3.7 0.3 21.1 1.8 34.1 3.7 15.6 118.3 29.4 1.1 0.6 5.1 2.3 6.8 1.1 306.1 0.0 1.7 1.2 0.0 290.3 531.0 7.6 9.3 266.2 10.6 45.9 176.8 0.2 2.1 2.0 1.3 0.8 0.4 3.0 2.9 0.5 0.4 30.6 1.5 0.4 0.0 31.0 3.0 27.1 92.8 27.2 8.8 118.5 3.3 3.6 1.2 0.9 CPXM1 "CPX-1, CPX1, CPXM" ENSG00000088882 "Carboxypeptidase X, M14 family member 1" Q96SM3 20 2794074-2800627 "Enzymes, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 86.0" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 162.7;Fibroblasts: 60.1;Theca cells: 28.2" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in many" 5 "cerebral cortex: 6.9" "Immune cell enhanced" "Detected in single" "NK-cell: 1.3" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "AF22: 161.7;HSkMC: 85.7;NB-4: 148.1;REH: 150.8;SH-SY5Y: 108.2" "Low region specificity" "Detected in all" "Region enhanced" "Detected in many" "spinal cord: 8.7" "Secreted in other tissues" NA NA 490000 "Cluster 48: NK-cells - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 12: NES - Nervous system development" "Cluster 36: Stromal cells - Cell proliferation" "unprognostic (7.48e-2)" "unprognostic (3.61e-1)" "unprognostic (6.70e-2)" "unprognostic (1.47e-2)" "unprognostic (3.41e-1)" "unprognostic (5.24e-2)" "unprognostic (1.82e-2)" "unprognostic (1.84e-2)" "unprognostic (2.98e-2)" "unprognostic (9.32e-2)" "unprognostic (7.02e-2)" "unprognostic (3.23e-2)" "prognostic unfavorable (4.62e-10)" "unprognostic (1.30e-1)" "unprognostic (1.49e-1)" "unprognostic (5.55e-3)" "unprognostic (1.27e-2)" 59.0 4.8 0.9 9.7 1.2 19.0 31.2 0.7 6.9 72.4 2.5 4.1 1.4 76.8 8.4 4.2 27.1 86.0 4.5 0.9 0.9 6.5 0.3 5.4 6.5 0.9 0.7 41.9 3.1 3.8 5.3 51.5 1.1 7.1 1.5 0.0 4.8 2.3 1.2 12.7 3.3 38.8 1.1 0.9 2.2 3.6 1.4 9.6 24.5 0.0 2.8 55.5 29.4 1.0 0.0 0.0 161.7 0.0 0.0 4.9 0.2 0.4 0.7 2.0 0.6 0.0 0.0 0.0 0.5 0.3 0.1 0.0 12.1 0.0 0.5 0.7 8.5 22.1 0.0 0.0 2.2 0.1 3.2 85.7 0.0 7.7 0.0 0.0 0.0 31.1 9.3 0.0 0.1 0.1 0.6 148.1 34.5 0.0 0.0 150.8 0.0 4.2 0.0 0.0 0.2 108.2 0.0 0.2 0.0 25.8 0.0 1.9 0.1 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 4.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.4 0.0 0.0 0.0 0.0 1.3 0.0 0.3 0.0 0.2 0.9 1.2 0.7 6.9 0.9 0.9 0.9 0.7 1.1 1.1 1.4 1.0 3.9 0.0 0.5 0.0 0.3 2.7 5.8 0.7 4.0 0.0 1.1 3.8 0.7 0.0 0.8 3.7 0.0 2.9 1.7 0.5 0.0 3.0 2.3 5.8 162.7 3.1 0.0 7.6 0.0 0.0 3.3 60.1 0.0 4.2 2.5 17.7 0.7 0.0 6.5 0.0 0.0 0.0 0.0 0.0 2.6 2.8 17.4 0.9 1.8 0.0 0.7 0.0 0.0 0.5 0.0 0.3 0.0 0.7 0.5 2.5 0.0 0.1 3.1 0.0 0.0 0.4 10.2 0.0 1.5 0.1 2.0 3.3 1.4 28.2 0.6 0.8 CPXM2 "CPX2, UNQ676" ENSG00000121898 "Carboxypeptidase X, M14 family member 2" Q8N436 10 123706207-123940267 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 81.3;intestine: 75.4" "Cell type enhanced" "Detected in many" "Early spermatids: 106.8;Late spermatids: 202.5;Oligodendrocytes: 35.6;Peritubular cells: 79.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 17 "BJ: 18.4;fHDF/TERT166: 71.8;SuSa: 28.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA048375 Uncertain "Secreted - unknown location" NA NA 62000 "Cluster 57: Non-specific - Angiogenesis" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "HPA048375: AB_2680377" "unprognostic (1.50e-1)" "unprognostic (3.66e-1)" "unprognostic (2.58e-2)" "unprognostic (4.02e-3)" "unprognostic (2.69e-2)" "unprognostic (6.48e-2)" "unprognostic (1.32e-2)" "unprognostic (1.32e-2)" "unprognostic (1.26e-1)" "unprognostic (8.57e-2)" "unprognostic (4.42e-2)" "unprognostic (2.14e-1)" "prognostic favorable (9.02e-4)" "unprognostic (3.48e-2)" "unprognostic (2.54e-2)" "unprognostic (1.27e-1)" "unprognostic (1.16e-3)" 29.1 6.4 3.9 5.9 7.2 0.0 20.8 9.2 2.6 5.8 81.3 75.4 6.2 10.2 59.8 18.4 16.0 11.2 18.0 3.5 7.2 11.2 2.4 7.0 2.7 16.1 10.7 16.7 5.2 2.5 10.9 1.2 11.6 15.1 7.0 0.5 9.3 12.7 3.8 7.3 14.9 56.9 20.0 16.8 19.9 9.6 10.4 7.8 15.0 7.9 6.6 28.3 9.2 18.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 18.4 0.7 1.1 0.1 0.0 0.0 0.0 0.0 71.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 2.2 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.2 0.1 28.0 0.5 0.0 0.0 0.1 0.1 0.3 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.9 7.2 9.2 2.6 3.5 7.2 16.1 10.7 11.6 20.0 10.4 18.3 22.3 0.0 0.6 0.3 0.1 2.2 0.0 0.2 6.2 0.0 0.3 0.4 2.4 0.0 0.0 1.8 0.0 8.3 0.1 0.2 1.9 0.4 106.8 0.2 0.2 26.1 0.0 0.0 5.0 0.2 0.3 23.0 1.1 0.3 0.0 0.1 16.8 0.0 0.3 1.7 0.5 0.7 0.0 0.0 2.7 202.5 10.8 0.6 3.6 0.0 0.0 0.0 0.0 1.0 35.6 0.1 0.1 79.0 1.4 0.0 0.4 0.0 0.0 0.1 0.0 1.6 2.0 1.3 1.9 0.6 2.0 5.1 0.2 0.0 2.7 0.2 CPZ ENSG00000109625 "Carboxypeptidase Z" Q66K79 4 8592660-8619759 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Wnt signaling pathway" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "ovary: 144.3" "Cell type enhanced" "Detected in some" "Endometrial stromal cells: 1.5;Fibroblasts: 8.5;Microglial cells: 2.8" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 73.6;BJ: 39.7;BJ hTERT+: 51.7;hTERT-RPE1: 30.6;RH-30: 57.6;U-2197: 46.0" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA078608 Approved "Plasma membrane" "Secreted to extracellular matrix" NA NA "Cluster 89: Fibroblasts - ECM organization" "Cluster 28: BEWO - Transcription regulation" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane" "HPA078608: " "unprognostic (2.58e-1)" "unprognostic (7.16e-2)" "unprognostic (4.83e-2)" "unprognostic (1.42e-1)" "unprognostic (7.77e-2)" "unprognostic (2.20e-2)" "unprognostic (2.98e-1)" "unprognostic (7.77e-2)" "unprognostic (2.30e-1)" "unprognostic (1.95e-2)" "unprognostic (1.41e-1)" "unprognostic (1.59e-1)" "unprognostic (7.23e-8)" "unprognostic (4.30e-3)" "unprognostic (3.58e-2)" "unprognostic (6.13e-4)" "unprognostic (5.51e-2)" 11.1 1.8 0.3 2.7 1.0 0.0 11.8 0.5 2.9 33.3 2.3 4.6 0.8 14.6 9.1 7.4 19.9 30.7 2.8 0.8 0.4 2.0 1.4 7.1 2.8 0.7 0.5 144.3 3.2 1.8 5.2 42.1 0.8 5.9 1.8 0.1 1.5 24.2 0.2 13.8 2.6 8.4 1.2 1.4 3.3 3.1 0.3 1.5 7.8 0.0 1.0 23.0 25.1 0.9 26.1 0.4 0.0 1.6 5.0 0.5 73.6 39.7 51.7 14.5 5.8 1.7 0.7 0.0 3.7 21.3 0.3 0.0 0.0 0.0 5.4 0.0 2.9 0.0 0.3 0.7 4.4 0.0 0.0 9.2 0.0 0.0 0.0 30.6 0.0 0.0 1.2 0.0 0.9 6.1 0.0 0.1 9.2 0.2 22.0 0.1 57.6 0.0 0.0 1.1 0.1 0.1 1.4 0.5 0.1 8.3 0.3 0.0 0.0 2.0 2.6 46.0 0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.0 0.5 2.9 0.8 0.4 0.7 0.5 0.8 1.2 0.3 0.9 0.0 0.0 0.0 0.3 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.6 0.0 0.6 8.5 0.5 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.9 0.1 0.0 2.8 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 CTRB1 CTRB ENSG00000168925 "Chymotrypsinogen B1" P17538 16 75218988-75226338 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" Digestion "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in many" 2384 "pancreas: 133851.7" "Cell type enriched" "Detected in some" 21 "Exocrine glandular cells: 31269.6" "Cancer enriched" "Detected in some" 1905 "pancreatic cancer: 962.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "EFO-21: 2.2;HDLM-2: 1.6" "Secreted to digestive system" NA NA "Cluster 25: Pancreas - Digestion" "Cluster 38: EFO-21 - Unknown function" "Cluster 1: Pancreatic cells - Digestion" "unprognostic (1.76e-1)" "unprognostic (2.62e-1)" "unprognostic (3.55e-1)" "unprognostic (1.57e-1)" "unprognostic (5.22e-2)" "unprognostic (4.43e-3)" "unprognostic (2.96e-1)" "unprognostic (1.17e-2)" 25.5 5.1 0.2 2.1 0.2 1.0 9.5 0.5 0.3 10.4 0.0 4.3 16.6 4.2 0.5 6.8 3.0 0.0 22.3 0.0 0.0 4.4 13.2 2.9 2.6 0.1 0.1 56.1 133851.7 0.0 7.2 6.5 0.1 5.6 0.0 0.0 22.3 0.2 3.8 5.8 8.9 0.0 0.0 11.7 7.6 3.4 0.1 0.0 2.8 0.1 0.0 2.4 3.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 2.2 0.0 0.1 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.9 0.1 0.7 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.5 0.3 0.0 0.0 0.1 0.1 0.1 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 39.7 0.0 0.1 0.1 2.0 0.0 0.0 0.1 31269.6 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 151.9 0.0 0.0 0.0 0.1 1430.4 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 7.9 0.0 0.2 0.0 0.0 0.0 0.0 1.2 0.0 0.0 CTRB2 ENSG00000168928 "Chymotrypsinogen B2" Q6GPI1 16 75204103-75207161 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" Digestion "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in many" 2443 "pancreas: 98661.0" "Cell type enriched" "Detected in some" 9 "Exocrine glandular cells: 53114.3" "Cancer enriched" "Detected in single" 1696 "pancreatic cancer: 540.0" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "EFO-21: 2.4;U-2 OS: 5.8;U-251 MG: 1.6;U-266/84: 1.8;U-698: 1.6" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Secreted to digestive system" NA NA "Cluster 25: Pancreas - Digestion" "Cluster 9: U-2 OS - Unknown function" "Cluster 1: Pancreatic cells - Digestion" "unprognostic (9.41e-4)" "unprognostic (2.20e-1)" "unprognostic (1.28e-2)" "unprognostic (2.10e-1)" "unprognostic (2.92e-2)" "unprognostic (2.77e-1)" "unprognostic (5.95e-2)" "unprognostic (9.56e-2)" "unprognostic (3.54e-3)" "unprognostic (7.06e-2)" "unprognostic (2.17e-1)" "unprognostic (7.57e-2)" 27.8 4.8 0.2 1.5 0.2 1.8 9.1 0.4 0.3 8.2 0.0 4.4 9.1 4.7 0.1 6.6 3.7 0.2 13.7 0.1 0.2 4.5 12.8 3.1 2.8 0.2 0.1 40.3 98661.0 0.0 5.7 5.6 0.2 11.8 0.0 0.0 16.7 0.1 3.7 5.2 6.6 0.0 0.1 7.2 8.1 3.7 0.2 0.0 3.1 0.0 0.0 2.8 4.8 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 5.8 0.0 1.6 0.0 1.8 1.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.4 0.3 0.1 0.2 0.2 0.1 0.2 0.1 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 108.8 2.0 0.3 0.0 1.5 0.0 0.0 0.0 53114.3 0.1 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 7.9 0.3 6.0 0.0 0.0 215.5 0.0 0.0 0.0 0.0 5324.0 0.0 0.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 30.2 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.1 CTRC "CLCR, ELA4" ENSG00000162438 "Chymotrypsin C" Q99895 1 15438442-15449242 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 3927 "pancreas: 25708.5" "Cell type enriched" "Detected in some" 9 "Exocrine glandular cells: 6566.4" "Cancer enriched" "Detected in some" 168 "pancreatic cancer: 236.0" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "basophil: 1.0" "Low lineage specificity" "Detected in single" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA046920 Enhanced "Secreted to digestive system" NA NA "Cluster 11: Basophils - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 1: Pancreatic cells - Digestion" "HPA046920: AB_2679865" "unprognostic (2.62e-2)" "unprognostic (2.58e-1)" "unprognostic (1.34e-1)" "unprognostic (2.81e-1)" "unprognostic (8.60e-2)" "unprognostic (1.06e-1)" "unprognostic (1.02e-1)" "unprognostic (1.23e-1)" "unprognostic (2.94e-2)" "unprognostic (7.60e-2)" "unprognostic (3.34e-1)" "unprognostic (2.00e-1)" "unprognostic (9.55e-11)" "unprognostic (4.98e-2)" "unprognostic (1.84e-1)" "unprognostic (1.50e-1)" "unprognostic (5.99e-3)" 6.5 1.2 0.2 0.2 0.2 0.7 2.9 0.7 0.3 2.7 0.2 1.2 1.1 1.3 0.1 1.9 0.8 0.0 2.3 0.3 0.1 1.2 3.5 1.0 0.3 0.1 0.1 5.6 25708.5 0.0 1.5 0.7 0.2 1.8 0.0 0.1 2.1 0.0 1.0 2.1 1.7 0.0 0.0 2.0 2.3 1.0 0.2 0.0 1.0 0.0 0.0 0.6 1.0 0.2 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.3 0.1 0.1 0.0 0.0 0.2 0.2 0.7 0.3 0.3 0.1 0.1 0.1 0.2 0.0 0.2 0.2 0.2 0.0 0.5 0.0 0.1 0.1 0.2 0.2 0.0 0.0 0.1 0.0 0.4 0.0 0.1 0.0 0.0 0.1 0.7 0.0 0.0 17.3 0.0 0.6 1.0 0.7 0.0 0.0 0.2 6566.4 0.1 0.2 0.0 2.1 0.0 0.2 0.0 0.0 0.1 0.0 0.2 0.2 0.0 0.0 0.9 0.0 0.0 1.1 1.8 0.0 24.3 0.0 1.0 0.0 0.0 673.8 0.0 0.0 0.1 0.3 0.4 0.1 0.0 0.0 0.0 1.3 3.5 0.0 0.0 0.0 0.3 0.0 0.3 0.0 0.1 0.3 CTRL ENSG00000141086 "Chymotrypsin like" P40313 16 67927640-67932365 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 1154 "pancreas: 7481.6" "Group enriched" "Detected in some" 20 "Exocrine glandular cells: 224.2;Pancreatic endocrine cells: 58.5" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HEK 293: 4.6" "Not detected" "Not detected" "Not detected" "Not detected" "HPA034504, HPA034505" Enhanced "Secreted to digestive system" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 1: Pancreatic cells - Digestion" "HPA034504: AB_2674196, HPA034505: AB_10602212" "unprognostic (3.03e-5)" "unprognostic (3.53e-3)" "unprognostic (3.46e-2)" "unprognostic (1.37e-1)" "unprognostic (9.66e-2)" "unprognostic (2.00e-2)" "unprognostic (1.24e-1)" "unprognostic (2.23e-1)" "unprognostic (1.18e-1)" "unprognostic (6.83e-3)" "unprognostic (6.41e-2)" "unprognostic (1.88e-1)" "unprognostic (3.20e-4)" "unprognostic (6.69e-2)" "unprognostic (2.79e-1)" "unprognostic (2.63e-1)" "unprognostic (1.29e-3)" 1.2 0.7 2.9 1.1 3.1 6.1 0.9 3.8 4.2 1.1 2.1 0.8 1.8 0.6 0.2 0.5 0.7 0.7 1.7 3.0 2.8 0.8 1.0 1.7 2.5 3.5 3.0 6.4 7481.6 0.0 1.7 0.7 3.7 1.2 0.5 0.3 1.1 0.2 0.6 1.0 1.7 0.4 2.8 3.5 1.0 0.6 3.3 1.9 0.7 0.7 1.0 0.7 0.7 3.5 0.4 2.1 0.6 0.2 0.1 0.0 0.9 0.3 0.4 0.7 1.0 1.9 1.0 0.5 0.3 0.4 0.6 0.7 4.1 0.7 2.0 0.8 4.6 0.5 0.9 1.9 0.2 0.3 1.4 0.7 0.1 2.5 0.7 0.3 0.0 1.0 1.0 1.1 0.3 0.7 0.4 2.2 4.1 1.1 1.9 2.0 0.3 3.1 0.0 0.8 1.9 1.1 0.7 0.7 0.4 0.4 0.9 2.5 0.9 0.1 1.4 0.2 1.0 3.8 1.7 2.2 0.1 0.7 0.2 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.4 0.3 0.0 0.1 0.1 0.0 0.0 2.9 3.1 3.8 4.2 3.0 2.8 3.5 3.0 3.7 2.8 3.3 3.5 0.6 0.0 0.0 1.6 0.2 0.5 0.0 0.0 2.2 0.0 0.2 0.1 0.1 0.0 0.8 0.0 0.0 0.0 0.3 0.8 0.0 0.6 0.0 0.0 0.1 0.1 0.0 0.0 1.3 224.2 0.0 0.5 1.1 0.1 0.0 0.2 0.0 0.0 0.1 0.0 1.7 0.4 2.0 1.2 0.3 0.0 0.0 0.5 0.0 1.0 2.1 0.0 0.0 0.5 1.6 58.5 1.4 0.0 0.2 0.1 0.3 0.1 0.2 0.0 0.0 0.1 0.3 0.0 0.0 0.2 0.3 0.0 0.6 6.9 0.5 0.1 CTSA "GSL, PPGB" ENSG00000064601 "Cathepsin A" P10619 20 45890144-45898824 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 368.3" "Cell type enhanced" "Detected in all" "Distal enterocytes: 445.6;Proximal enterocytes: 301.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "ASC diff: 856.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB024930, HPA031068, HPA072487" Enhanced Enhanced Vesicles "Intracellular and membrane" NA NA 28000000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 51: Myeloid cells - Hemostasis" Vesicles "CAB024930: , HPA031068: AB_10601205, HPA072487: " "unprognostic (8.61e-2)" "unprognostic (3.37e-1)" "unprognostic (4.30e-2)" "unprognostic (2.13e-1)" "unprognostic (6.42e-2)" "unprognostic (2.21e-1)" "prognostic unfavorable (1.95e-4)" "unprognostic (6.33e-2)" "unprognostic (9.53e-3)" "unprognostic (7.19e-2)" "unprognostic (1.83e-1)" "unprognostic (6.85e-2)" "unprognostic (7.57e-2)" "unprognostic (1.09e-1)" "unprognostic (6.05e-2)" "unprognostic (1.71e-1)" "unprognostic (8.40e-2)" 80.4 368.3 56.8 75.3 58.1 75.6 61.9 63.6 65.6 47.6 96.0 178.6 100.9 55.1 39.0 60.4 39.3 89.7 97.2 59.7 63.8 188.1 95.7 90.9 61.6 62.6 59.1 62.2 52.9 104.4 43.8 76.4 61.4 38.5 170.4 44.0 61.3 48.4 56.0 95.2 109.2 67.3 59.4 108.5 63.3 33.5 70.2 23.0 47.4 61.7 58.8 82.8 49.2 68.4 111.9 114.1 17.6 89.2 856.5 438.6 47.0 150.3 424.0 169.6 217.5 214.4 291.8 24.1 176.2 299.9 638.1 168.6 55.9 105.6 95.7 47.6 53.6 54.3 53.4 375.9 187.3 98.0 240.9 349.0 123.6 107.9 22.5 421.9 190.1 28.2 61.0 355.1 186.9 232.1 25.8 82.4 19.4 172.6 272.1 37.8 107.3 135.7 138.2 96.7 36.9 37.8 263.2 450.3 444.4 51.5 108.5 141.8 172.5 335.0 76.2 178.9 123.7 162.1 238.5 15.7 599.3 128.6 142.4 480.7 305.9 530.5 44.9 168.8 185.5 42.0 75.6 78.3 102.4 25.7 26.6 39.8 152.4 81.2 120.1 40.6 155.4 378.1 56.8 58.1 63.6 65.6 59.7 63.8 62.6 59.1 61.4 59.4 70.2 68.4 53.7 35.3 32.6 26.1 38.2 24.2 38.9 88.8 17.6 58.4 18.4 15.9 12.6 65.8 64.1 71.7 60.5 104.1 27.5 445.6 39.2 246.0 3.3 22.3 39.5 56.0 54.0 22.1 20.4 166.4 109.2 86.8 29.6 62.4 9.5 50.8 102.1 67.9 297.1 47.1 25.2 74.5 95.6 177.1 25.1 4.8 32.9 273.1 112.1 12.2 135.6 86.6 37.0 7.1 10.2 135.0 216.0 27.4 41.9 18.6 301.8 245.8 34.2 46.1 26.3 33.7 54.5 15.3 31.9 24.0 22.9 144.1 49.1 91.3 113.9 36.2 CTSB ENSG00000164733 "Cathepsin B" P07858 8 11842524-11869533 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hofbauer cells: 2744.5;Kupffer cells: 1774.9;Macrophages: 1224.3" "Cancer enriched" "Detected in all" 5 "thyroid cancer: 1446.9" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 4 "basophil: 390.6;classical monocyte: 610.1;intermediate monocyte: 467.3;myeloid DC: 287.4;non-classical monocyte: 307.6;plasmacytoid DC: 410.1" "Group enriched" "Detected in all" 6 "dendritic cells: 410.1;granulocytes: 390.6;monocytes: 610.1" "Cell line enhanced" "Detected in all" "BJ hTERT+: 1607.5;fHDF/TERT166: 1436.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000457, HPA018156, HPA048998" Enhanced Supported Nucleoli,Vesicles "Secreted to blood" NA NA 100000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 72: Non-specific - Transcription" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 4: Macrophages - Innate immune response" Vesicles Nucleoli "CAB000457: , HPA018156: AB_1846069, HPA048998: " "unprognostic (5.74e-2)" "unprognostic (4.32e-2)" "unprognostic (1.38e-2)" "unprognostic (2.17e-2)" "unprognostic (2.98e-3)" "unprognostic (5.96e-2)" "unprognostic (1.36e-2)" "unprognostic (1.07e-1)" "unprognostic (2.82e-2)" "unprognostic (1.06e-1)" "unprognostic (7.61e-2)" "unprognostic (8.30e-2)" "unprognostic (2.85e-1)" "unprognostic (7.39e-2)" "unprognostic (4.12e-2)" "prognostic favorable (5.76e-4)" "prognostic unfavorable (9.02e-4)" 443.9 304.5 65.6 399.7 71.2 87.0 249.0 65.9 77.2 583.2 101.0 312.4 120.8 379.2 116.9 421.6 368.4 230.6 447.0 64.7 95.5 420.6 497.2 428.9 289.6 100.4 90.8 169.1 135.4 79.6 156.8 253.2 107.4 255.5 159.3 33.6 437.3 156.6 237.4 184.7 260.2 316.1 91.9 521.1 194.3 33.2 204.5 60.9 1150.7 99.3 104.0 431.9 477.8 159.2 66.6 283.4 4.0 94.9 657.3 754.5 128.3 885.0 1607.5 258.4 299.5 10.3 294.4 1.5 32.2 1436.1 419.3 279.5 65.3 157.1 195.6 25.9 52.6 58.8 10.0 397.1 479.2 7.7 73.7 296.4 532.2 327.2 427.3 611.5 33.4 20.2 81.7 260.7 194.6 62.5 6.5 23.1 16.3 839.7 91.3 33.6 39.3 202.7 2.6 121.1 4.9 68.6 165.1 68.6 514.6 110.1 97.8 68.7 922.4 766.5 111.9 129.9 259.3 182.7 178.5 4.8 432.5 22.9 249.4 390.6 610.1 90.6 26.3 467.3 35.4 44.1 79.0 31.5 287.4 38.8 48.3 21.5 97.8 31.3 307.6 410.1 78.7 703.7 65.6 71.2 65.9 77.2 64.7 95.5 100.4 90.8 107.4 91.9 204.5 159.2 87.7 109.0 171.4 17.6 54.8 54.7 441.6 563.2 54.7 55.2 94.1 74.5 320.1 165.8 331.7 114.0 41.7 279.4 122.4 147.9 27.4 294.6 15.6 105.8 240.1 163.0 154.7 210.2 36.2 238.2 341.7 155.0 44.4 183.5 179.4 105.9 204.2 239.5 2744.5 58.9 42.8 94.2 158.7 1774.9 436.5 18.5 76.4 1224.3 161.9 70.3 373.1 117.4 24.7 19.1 12.9 363.9 154.0 92.9 47.3 295.5 198.6 351.8 180.8 40.0 39.5 39.4 149.9 10.8 21.0 160.3 40.5 649.6 56.0 32.1 139.6 321.4 CTSC "DPP1, PALS, PLS" ENSG00000109861 "Cathepsin C" P53634 11 88265069-88359684 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Thiol protease" "Disease variant, Palmoplantar keratoderma" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 900.7;Club cells: 471.8;Hofbauer cells: 1100.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "BJ hTERT+: 1078.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025364, HPA066610, HPA068434" Enhanced Supported Vesicles "Intracellular and membrane" No No 19000000 "Cluster 51: Monocytes - Innate immune response" "Cluster 19: Lung - Lung function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Vesicles "CAB025364: , HPA066610: AB_2685694, HPA068434: AB_2685989" "unprognostic (4.05e-2)" "unprognostic (1.35e-1)" "unprognostic (1.50e-1)" "unprognostic (1.10e-1)" "unprognostic (3.70e-2)" "unprognostic (1.45e-2)" "prognostic unfavorable (9.30e-5)" "unprognostic (1.62e-1)" "unprognostic (1.04e-1)" "unprognostic (1.56e-2)" "unprognostic (3.11e-2)" "unprognostic (3.35e-1)" "prognostic favorable (4.80e-4)" "unprognostic (2.93e-1)" "unprognostic (4.35e-2)" "unprognostic (8.10e-2)" "unprognostic (4.07e-2)" 173.2 60.7 9.9 185.1 9.6 71.7 63.4 11.1 24.9 77.9 14.2 143.1 121.0 43.9 28.5 63.3 54.0 182.0 38.5 9.5 10.1 234.7 82.0 272.6 243.7 14.0 11.9 22.1 52.2 42.4 39.3 253.3 13.3 26.0 191.5 3.7 131.6 28.9 18.8 29.6 128.8 88.9 11.5 197.2 73.6 22.8 19.5 63.7 43.6 31.9 140.6 176.3 43.3 21.3 80.3 75.9 27.6 69.9 103.7 286.1 218.4 626.5 1078.4 372.8 270.3 194.7 361.3 117.3 278.9 365.2 84.3 133.6 50.4 269.2 341.9 204.7 82.8 144.5 188.0 233.5 140.2 188.9 108.7 419.1 198.8 284.5 697.4 302.1 377.6 122.3 155.3 145.4 54.8 14.8 89.1 295.1 172.2 551.5 244.9 113.6 30.7 227.0 451.3 106.6 8.8 66.8 81.2 114.9 80.6 185.4 27.9 152.7 149.3 23.5 190.5 156.8 364.6 61.9 81.0 122.9 56.8 435.8 122.4 85.5 203.8 309.7 230.1 415.6 194.9 47.2 99.6 198.2 209.9 26.3 49.5 115.3 215.0 200.5 582.9 425.0 162.7 243.3 9.9 9.6 11.1 24.9 9.5 10.1 14.0 11.9 13.3 11.5 19.5 21.3 78.6 22.4 88.1 0.3 40.8 30.1 7.3 900.7 33.6 1.5 15.9 14.6 4.4 52.9 471.8 40.5 0.0 414.1 330.6 37.9 29.4 29.8 1.6 13.4 135.6 94.8 11.4 29.7 3.0 90.6 159.2 114.4 39.8 21.2 75.3 25.5 26.4 15.8 1100.6 0.0 8.2 19.4 158.7 344.7 200.7 7.9 198.5 391.7 48.0 61.8 185.4 0.5 299.7 13.6 0.4 44.8 72.3 25.6 78.5 8.5 20.2 166.4 93.7 0.8 59.2 4.4 150.8 3.0 11.1 43.3 27.1 227.3 170.6 286.7 44.9 16.1 CTSD "CLN10, CPSD" ENSG00000117984 "Cathepsin D" P07339 11 1752752-1764573 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Aspartyl protease, Hydrolase, Protease" "Alzheimer disease, Cancer-related genes, Disease variant, Neurodegeneration, Neuronal ceroid lipofuscinosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 1475.9;Hofbauer cells: 3763.5;Macrophages: 1512.6;Proximal enterocytes: 1699.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "CAPAN-2: 2596.6;hTERT-RPE1: 2780.1;SK-BR-3: 2488.5" "CAB000109, HPA003001" Supported "Secreted to blood" NA NA 370000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 4: Macrophages - Innate immune response" "CAB000109: , HPA003001: AB_1078404" "unprognostic (9.95e-2)" "unprognostic (1.62e-1)" "prognostic unfavorable (2.46e-4)" "unprognostic (1.09e-1)" "unprognostic (1.71e-3)" "unprognostic (2.65e-2)" "unprognostic (9.40e-3)" "unprognostic (1.11e-1)" "unprognostic (1.52e-1)" "unprognostic (1.12e-3)" "unprognostic (1.59e-1)" "unprognostic (1.86e-2)" "prognostic favorable (4.93e-5)" "unprognostic (8.98e-2)" "unprognostic (3.39e-2)" "unprognostic (2.13e-2)" "unprognostic (1.60e-1)" 318.6 734.6 147.0 204.9 181.9 499.0 244.0 186.0 156.5 270.8 672.7 298.0 387.6 170.7 82.8 319.4 171.6 438.4 444.1 187.8 223.6 691.6 464.8 539.6 241.0 247.6 206.6 130.7 284.8 137.3 131.5 180.7 228.6 138.2 153.4 48.3 422.1 231.7 590.3 340.9 398.3 105.0 188.9 442.0 287.2 88.9 334.4 78.1 182.1 178.2 123.1 296.4 307.5 367.1 204.6 578.9 51.4 246.2 586.5 206.3 112.1 149.4 362.2 161.8 182.8 147.5 2596.6 49.2 376.8 285.8 1265.6 1072.2 63.7 142.6 35.8 206.7 222.9 70.4 92.5 196.5 736.2 171.4 787.7 350.9 621.6 82.5 136.9 2780.1 128.2 62.1 89.2 267.6 263.3 832.6 47.0 110.9 153.1 719.7 247.9 62.5 72.5 191.2 586.6 610.8 84.2 94.8 173.3 2488.5 535.0 68.6 1022.8 232.6 170.3 556.8 92.9 79.0 216.7 432.0 382.3 26.8 867.7 468.6 509.6 211.2 578.7 170.1 156.5 309.9 90.6 28.8 72.1 110.3 144.5 18.8 82.5 107.4 319.5 192.3 265.2 120.3 89.2 489.1 147.0 181.9 186.0 156.5 187.8 223.6 247.6 206.6 228.6 188.9 334.4 367.1 139.3 112.2 228.6 48.3 62.8 72.0 223.5 473.2 71.7 168.6 108.9 113.8 251.9 314.5 459.5 548.1 110.5 211.7 156.1 1475.9 109.5 911.4 3.3 118.1 67.4 128.3 159.6 132.6 18.3 370.1 165.0 157.0 237.5 203.4 474.3 119.4 695.7 678.9 3763.5 264.2 25.2 418.2 498.5 1187.8 67.5 14.6 108.4 1512.6 227.7 20.6 382.6 179.0 256.4 27.2 42.2 392.3 832.5 128.2 122.5 111.7 1699.4 311.8 270.3 102.1 111.7 70.7 135.2 26.6 63.5 141.2 82.1 471.3 155.0 96.0 399.1 357.8 CTSE ENSG00000196188 "Cathepsin E" P14091 1 206008535-206023909 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Aspartyl protease, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "stomach 1: 1168.3" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 105.8;Exocrine glandular cells: 262.8;Gastric mucus-secreting cells: 553.5;Pancreatic endocrine cells: 260.0;Paneth cells: 208.9" "Cancer enhanced" "Detected in many" "pancreatic cancer: 297.4;stomach cancer: 200.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 46 "OE19: 1799.1" "Not detected" "Not detected" "HPA012674, HPA012940, CAB032687" Enhanced Approved Vesicles "Intracellular and membrane" NA NA "Cluster 4: Stomach - Digestion" "Cluster 21: OE19 - Mitochondria" "Cluster 16: Pancreatic endocrine cells - Mixed function" Vesicles "CAB032687: AB_637901, HPA012674: , HPA012940: AB_2668773" "unprognostic (1.17e-2)" "unprognostic (2.45e-1)" "unprognostic (1.31e-2)" "unprognostic (2.72e-2)" "unprognostic (1.35e-2)" "unprognostic (2.52e-3)" "unprognostic (1.45e-1)" "unprognostic (3.29e-2)" "unprognostic (2.87e-2)" "unprognostic (1.20e-2)" "unprognostic (1.39e-1)" "unprognostic (6.37e-3)" "unprognostic (1.42e-1)" "unprognostic (5.45e-2)" "unprognostic (2.61e-2)" "prognostic favorable (5.26e-5)" 0.3 0.0 0.1 9.5 0.1 30.0 0.0 0.5 0.3 0.0 0.1 15.3 229.8 0.3 1.7 0.8 1.1 15.0 0.3 0.1 0.1 0.2 0.2 49.7 0.5 0.3 0.1 0.1 3.7 0.0 1.1 1.3 0.3 0.2 25.7 0.1 0.0 1.6 0.0 0.1 55.5 0.3 0.1 0.6 1168.3 0.1 0.3 0.5 8.9 0.0 10.7 5.8 0.2 0.5 0.3 0.0 0.0 0.0 0.0 0.0 20.2 0.0 0.0 0.0 0.0 0.8 0.8 0.0 3.8 0.0 0.7 0.6 0.0 0.0 0.0 0.0 0.0 0.7 0.2 2.4 0.0 1.0 3.9 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.2 0.1 0.0 0.0 0.8 1.5 0.7 1799.1 0.1 0.4 0.0 0.8 0.7 39.4 0.2 0.5 0.0 0.0 0.4 0.1 0.1 0.1 0.0 0.0 0.7 0.0 0.2 0.3 0.0 0.1 0.0 0.0 0.2 0.5 0.1 0.0 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.3 0.2 0.1 0.6 0.2 0.1 0.2 0.1 0.0 0.1 0.1 0.5 0.3 0.1 0.1 0.3 0.1 0.3 0.1 0.3 0.5 0.0 105.8 27.9 0.0 0.6 0.0 0.1 0.6 0.0 0.0 0.0 0.0 0.5 10.0 42.3 0.0 0.0 0.0 0.0 34.1 0.0 52.0 0.0 0.3 0.0 0.3 2.4 60.6 0.0 262.8 0.1 14.7 553.5 0.6 0.0 0.0 0.0 0.2 0.2 0.0 0.0 21.1 0.0 0.3 0.0 0.0 0.0 0.9 0.0 0.0 1.6 0.0 0.0 0.0 0.1 260.0 208.9 0.0 0.7 0.1 4.0 0.1 7.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.5 0.1 10.4 0.4 CTSF "CATSF, CLN13" ENSG00000174080 "Cathepsin F" Q9UBX1 11 66563464-66568879 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Disease variant, Neurodegeneration, Neuronal ceroid lipofuscinosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Late spermatids: 320.9;Muller glia cells: 196.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "SiHa: 23.1;SK-MEL-30: 59.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002141, HPA031431" Approved Supported "Endoplasmic reticulum,Vesicles,Plasma membrane" "Intracellular and membrane" NA NA 5800000 "Cluster 15: NK-cells - Transcription" "Cluster 35: Non-specific - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 5: Muller glia cells - Visual perception" Vesicles "Endoplasmic reticulum, Plasma membrane" "CAB002141: AB_563471, HPA031431: " "unprognostic (1.52e-2)" "unprognostic (1.08e-1)" "unprognostic (1.03e-1)" "unprognostic (7.22e-3)" "unprognostic (2.25e-2)" "unprognostic (6.72e-2)" "unprognostic (2.67e-2)" "unprognostic (2.76e-2)" "unprognostic (3.69e-1)" "unprognostic (4.14e-1)" "unprognostic (1.69e-2)" "unprognostic (9.12e-2)" "prognostic favorable (8.92e-7)" "unprognostic (1.36e-2)" "unprognostic (1.28e-1)" "unprognostic (3.89e-1)" "unprognostic (2.42e-1)" 57.8 70.0 68.1 0.8 76.3 0.3 62.2 74.5 74.0 78.8 90.2 76.7 3.0 89.2 21.9 15.6 70.8 10.0 100.2 63.2 74.2 46.9 66.0 32.9 3.6 75.0 70.3 99.1 31.7 20.0 43.3 3.8 68.4 53.5 3.5 26.2 55.7 17.1 91.9 44.4 29.5 12.2 77.2 25.0 54.3 109.7 71.0 3.0 40.6 27.6 3.0 56.6 58.7 86.6 0.0 17.0 3.1 5.4 14.2 8.6 3.4 13.0 11.4 6.3 2.3 0.0 2.2 0.0 21.3 10.4 0.0 1.2 6.8 2.6 4.8 3.7 0.0 0.5 7.0 0.0 9.9 0.3 4.4 22.3 9.1 0.8 1.6 13.7 3.8 2.0 5.4 1.6 5.2 4.6 0.1 1.7 0.9 3.7 9.7 0.0 0.0 1.5 7.1 0.3 4.3 6.9 23.1 0.3 59.5 0.3 7.4 0.6 3.3 1.8 2.9 1.5 1.2 21.2 0.2 0.0 2.2 0.0 2.9 0.0 0.4 0.3 3.9 0.6 4.1 1.5 3.5 4.6 0.6 1.4 6.4 4.1 0.1 4.6 0.2 0.9 1.3 2.2 68.1 76.3 74.5 74.0 63.2 74.2 75.0 70.3 68.4 77.2 71.0 86.6 36.6 12.8 15.6 31.3 5.9 39.8 62.4 8.5 37.5 107.9 45.3 80.6 57.9 41.5 7.4 36.8 41.7 31.6 9.6 0.6 15.6 13.1 163.3 1.7 22.8 27.2 12.0 11.4 26.5 7.5 9.5 118.1 8.2 5.3 9.5 52.1 56.0 67.8 14.9 134.6 31.3 3.1 18.3 21.5 32.8 320.9 145.7 13.1 156.5 12.2 3.1 196.6 17.5 21.6 29.4 5.9 3.2 121.9 12.9 50.5 1.3 44.7 3.3 77.9 78.9 62.0 45.9 169.6 43.3 3.6 25.3 23.7 9.5 30.7 4.3 32.9 CTSG CG ENSG00000100448 "Cathepsin G" P08311 14 24573518-24576250 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Antibiotic, Antimicrobial, Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 154 "bone marrow: 5352.9" "Cell type enriched" "Detected in some" 16 "granulocytes: 534.9" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in some" 7 "THP-1: 8681.4" "Not detected" "Not detected" "Not detected" "Not detected" "CAB000110, HPA047737" Enhanced "Intracellular and membrane" NA NA 330000 "Cluster 33: Neutrophils - Chromatin organization" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 43: THP-1 - Innate immune response" "Cluster 60: Granulocytes - Receptor signaling" "CAB000110: , HPA047737: AB_2680140" "unprognostic (1.67e-1)" "unprognostic (2.57e-2)" "unprognostic (6.92e-2)" "unprognostic (1.08e-1)" "prognostic favorable (1.57e-4)" "unprognostic (4.05e-2)" "unprognostic (4.13e-2)" "unprognostic (3.06e-1)" "unprognostic (2.42e-1)" "unprognostic (2.60e-2)" "unprognostic (2.05e-2)" "unprognostic (1.63e-3)" "unprognostic (1.07e-2)" "unprognostic (1.09e-1)" "unprognostic (1.37e-1)" "prognostic unfavorable (8.91e-4)" 23.4 0.1 0.0 13.5 0.0 5352.9 25.4 0.0 0.0 16.6 0.0 25.5 5.8 9.6 10.2 22.1 2.7 25.9 3.7 0.0 0.0 2.3 3.6 11.6 6.5 0.0 0.0 0.5 3.5 1.5 1.0 2.9 0.0 3.7 25.5 0.0 11.5 4.8 1.8 28.0 18.1 7.7 0.0 16.9 4.9 3.2 0.0 26.0 0.8 7.6 6.0 34.8 4.1 0.0 6.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 303.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 33.2 0.0 0.1 0.0 0.0 3.6 41.5 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.0 0.0 0.0 1.2 0.0 3.6 0.0 0.0 8681.4 0.0 0.0 0.3 0.0 5.3 0.0 0.8 2.8 0.0 1287.5 0.1 0.0 6.0 0.0 1.1 1.0 0.0 0.0 0.9 3.4 5.4 0.0 0.0 1.7 7.3 5.0 0.0 6.5 0.0 19.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 12.8 33.3 0.0 0.2 6.4 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 2.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 6.3 0.0 0.0 2.4 0.0 1.3 0.0 0.0 0.1 1.0 0.0 0.0 534.9 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.6 11.1 9.1 0.0 1.5 5.4 0.0 1.8 0.0 2.1 0.0 0.0 0.0 0.0 0.0 5.3 0.0 0.0 0.0 0.7 0.0 0.0 0.2 1.3 0.3 1.7 0.0 4.0 0.0 5.1 0.0 0.4 0.0 CTSH "ACC-4, ACC-5, ACC4, ACC5, CPSB" ENSG00000103811 "Cathepsin H" P09668 15 78921058-78949574 "Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lung: 349.6" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 1569.9;Proximal tubular cells: 523.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "classical monocyte: 208.5;intermediate monocyte: 137.7;memory B-cell: 83.3;myeloid DC: 183.6;naive B-cell: 56.0;non-classical monocyte: 94.8" "Group enriched" "Detected in all" 5 "B-cells: 83.3;dendritic cells: 183.6;monocytes: 208.5" "Cell line enhanced" "Detected in many" "CAPAN-2: 306.4;HaCaT: 228.2;HDLM-2: 183.0;OE19: 197.4;RT4: 362.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000458, HPA003524" Enhanced Supported "Vesicles,Cytosol,Cytoplasmic bodies" "Intracellular and membrane" NA NA 8700000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 11: Alveolar cells - Smell perception" "Vesicles, Cytosol, Cytoplasmic bodies" "CAB000458: , HPA003524: AB_1846075" "unprognostic (6.47e-2)" "unprognostic (4.65e-3)" "unprognostic (1.05e-1)" "prognostic favorable (6.90e-4)" "unprognostic (4.37e-2)" "unprognostic (1.93e-1)" "unprognostic (7.18e-2)" "unprognostic (3.30e-3)" "unprognostic (2.22e-1)" "unprognostic (5.96e-2)" "unprognostic (4.10e-2)" "unprognostic (3.89e-2)" "unprognostic (6.63e-3)" "unprognostic (3.83e-1)" "unprognostic (4.42e-2)" "unprognostic (2.70e-3)" "unprognostic (1.79e-3)" 34.3 36.4 29.4 100.6 30.2 36.9 48.8 29.9 47.1 112.8 31.4 32.5 77.8 46.7 26.8 37.9 57.6 104.6 51.3 29.6 32.9 238.2 89.5 349.6 191.8 30.8 31.4 30.0 75.5 77.6 10.1 25.7 31.5 59.7 27.3 4.7 63.0 70.7 16.3 48.4 56.7 43.1 30.7 51.8 93.9 10.1 32.7 51.8 27.7 37.7 131.3 202.2 30.6 32.4 122.0 10.0 1.2 30.5 5.4 0.5 20.3 8.6 3.0 13.9 7.0 17.6 306.4 34.6 12.6 0.0 13.5 228.2 5.2 52.6 10.1 183.0 0.4 3.0 1.3 38.4 12.1 0.4 7.1 5.6 10.7 0.2 0.0 59.4 1.0 5.9 76.0 0.0 17.9 2.8 32.6 87.8 8.9 197.4 4.9 0.3 0.4 5.9 49.9 362.1 2.6 5.2 41.5 27.8 75.4 10.1 12.5 48.0 16.4 0.2 6.2 0.0 5.3 0.8 92.4 19.5 0.1 89.2 12.3 0.0 208.5 2.0 7.6 137.7 29.7 83.3 20.5 7.4 183.6 56.0 1.8 3.8 8.7 3.2 94.8 22.9 18.3 147.5 29.4 30.2 29.9 47.1 29.6 32.9 30.8 31.4 31.5 30.7 32.7 32.4 169.8 237.2 1569.9 59.1 127.4 24.2 280.7 363.9 30.1 1.3 45.5 41.7 26.2 358.9 258.7 367.8 4.2 19.8 8.1 9.1 84.1 225.0 25.3 67.0 86.0 124.5 9.1 3.0 2.2 142.0 39.6 53.8 106.0 42.8 32.8 2.7 14.3 115.5 256.7 0.0 2.9 18.6 101.7 177.8 259.6 22.6 73.0 350.4 80.0 15.9 360.9 22.6 5.2 1.5 1.1 84.6 16.0 6.0 155.8 112.0 153.0 523.2 261.6 6.6 19.7 4.5 22.3 12.3 56.4 41.6 18.6 23.4 29.4 17.8 40.1 340.4 CTSK "CTSO, CTSO2, PKND, PYCD" ENSG00000143387 "Cathepsin K" P43235 1 150794880-150809577 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Thiol protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "cervix: 420.6" "Cell type enhanced" "Detected in many" "Fibroblasts: 372.4;Langerhans cells: 123.6;Leydig cells: 119.0;Melanocytes: 97.8;Peritubular cells: 149.7;Theca cells: 80.9" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in all" 6 "cerebral cortex: 18.1" "Immune cell enhanced" "Detected in some" "classical monocyte: 1.8" "Lineage enriched" "Detected in single" 4 "monocytes: 1.8" "Group enriched" "Detected in many" 9 "ASC diff: 2284.0;ASC TERT1: 813.2;BJ hTERT+: 1949.1" "Low region specificity" "Detected in all" HPA050346 Supported Vesicles "Intracellular and membrane" NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 46: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" Vesicles "HPA050346: AB_2681101" "unprognostic (1.48e-1)" "unprognostic (9.29e-2)" "unprognostic (1.21e-1)" "unprognostic (7.61e-3)" "unprognostic (5.08e-2)" "unprognostic (6.57e-2)" "unprognostic (1.02e-1)" "unprognostic (6.60e-2)" "unprognostic (2.11e-1)" "unprognostic (1.01e-1)" "unprognostic (1.49e-1)" "unprognostic (3.54e-2)" "prognostic unfavorable (7.12e-5)" "unprognostic (6.07e-3)" "unprognostic (2.98e-2)" "unprognostic (5.93e-3)" "unprognostic (6.41e-2)" 224.1 12.5 2.7 33.1 2.8 3.1 227.7 2.9 18.1 420.6 16.4 68.6 13.8 334.0 44.9 46.0 74.0 299.2 35.8 2.7 2.6 12.7 9.0 36.4 42.1 2.7 2.7 78.4 10.6 6.1 14.6 18.9 2.6 34.1 61.8 6.9 53.3 38.0 15.7 219.8 63.8 141.6 2.8 20.2 41.7 15.1 2.7 12.3 34.7 46.3 48.7 210.5 176.2 2.9 0.7 0.3 1.4 0.8 2284.0 813.2 1.0 55.2 1949.1 3.3 8.3 0.3 0.3 0.4 0.6 129.8 0.0 0.6 0.3 0.4 1.2 0.4 0.4 1.4 0.5 0.0 11.0 0.2 1.3 156.5 1.7 50.5 0.7 137.6 4.2 0.6 0.4 1.4 1.5 1.4 0.0 3.0 10.2 1.0 0.0 0.2 0.1 0.1 3.2 0.1 0.6 2.9 0.4 0.0 29.3 3.9 1.0 1.5 1.0 0.7 0.5 0.6 0.6 2.3 1.7 3.6 184.1 0.0 9.9 0.0 1.8 0.2 0.0 1.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.3 0.2 0.4 0.6 2.7 2.8 2.9 18.1 2.7 2.6 2.7 2.7 2.6 2.8 2.7 2.9 17.9 3.2 4.6 2.6 1.1 68.8 0.5 1.6 2.2 12.1 3.7 9.5 2.0 1.5 3.9 3.7 4.2 1.3 2.8 1.5 0.0 1.0 0.9 2.5 59.0 10.2 1.2 0.8 5.0 0.2 2.5 372.4 11.2 3.8 0.0 77.5 14.6 0.5 21.4 3.3 7.7 1.6 8.2 4.6 123.6 4.4 119.0 8.7 97.8 7.5 4.9 2.7 3.1 7.1 2.5 1.4 1.4 149.7 0.8 1.0 1.4 0.1 2.2 7.7 13.1 4.5 33.9 1.4 1.0 2.6 59.1 1.0 5.4 80.9 1.0 0.7 CTSL "CTSL1, FLJ31037" ENSG00000135047 "Cathepsin L" P07711 9 87724051-87731469 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "placenta: 563.6" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 1081.6;Extravillous trophoblasts: 1012.3;Hepatic stellate cells: 580.4;Hofbauer cells: 1105.7;Macrophages: 537.2;Syncytiotrophoblasts: 1543.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 10 "intermediate monocyte: 128.1;non-classical monocyte: 195.2" "Lineage enriched" "Detected in many" 12 "monocytes: 195.2" "Cell line enhanced" "Detected in many" "ASC TERT1: 2305.0;HSkMC: 1061.0" "Low region specificity" "Detected in all" "CAB000459, HPA070413" Enhanced Approved "Golgi apparatus,Vesicles" "Intracellular and membrane" NA NA 17000000 "Cluster 51: Monocytes - Innate immune response" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 4: Macrophages - Innate immune response" "Golgi apparatus, Vesicles" "CAB000459: AB_2292484, HPA070413: " "unprognostic (1.05e-1)" "unprognostic (1.01e-1)" "unprognostic (1.24e-2)" "unprognostic (1.53e-1)" "prognostic unfavorable (3.73e-4)" "unprognostic (1.19e-3)" "unprognostic (8.12e-3)" "prognostic unfavorable (5.15e-5)" "unprognostic (2.09e-1)" "unprognostic (3.15e-1)" "unprognostic (6.80e-2)" "unprognostic (3.21e-1)" "prognostic favorable (4.34e-4)" "unprognostic (5.64e-3)" "unprognostic (2.26e-2)" "unprognostic (1.72e-1)" "unprognostic (7.11e-3)" 232.4 86.6 49.2 136.0 55.4 84.8 110.0 52.9 67.5 69.5 67.9 110.3 39.7 108.1 81.6 33.3 108.4 85.0 112.5 47.0 52.3 207.3 333.5 154.9 101.1 54.4 54.0 96.4 61.9 151.1 69.5 563.6 57.5 68.2 58.8 32.3 77.6 91.7 71.9 39.8 57.1 125.2 52.4 124.4 71.4 80.1 112.2 33.0 76.1 79.8 49.4 209.8 48.0 59.6 88.1 423.0 32.6 55.3 514.0 2305.0 198.4 267.2 781.8 232.2 300.6 43.0 86.3 0.0 128.9 355.4 754.0 67.5 49.8 86.0 198.4 1.9 37.8 18.1 111.2 105.1 352.6 0.1 51.4 1061.0 138.9 373.7 134.9 186.6 194.9 0.0 162.5 0.7 326.6 115.6 0.5 9.9 67.7 128.6 77.5 21.6 21.5 0.6 158.6 39.0 42.8 50.6 62.1 133.5 312.3 177.9 14.5 97.9 296.9 190.8 104.7 750.6 125.9 18.5 84.1 0.9 692.6 0.2 67.9 0.3 13.5 0.6 0.3 128.1 0.0 0.0 6.6 0.1 7.9 0.1 16.7 1.3 0.5 0.2 195.2 0.3 1.7 10.1 49.2 55.4 52.9 67.5 47.0 52.3 54.4 54.0 57.5 52.4 112.2 59.6 86.1 41.7 52.9 15.3 11.2 37.7 82.1 58.0 15.4 43.8 12.2 33.4 96.8 87.2 46.4 75.4 18.8 1081.6 0.3 16.3 27.4 91.8 5.3 48.1 119.9 110.0 11.5 251.2 18.6 93.4 1012.3 261.7 10.2 27.6 29.7 63.6 580.4 122.6 1105.7 13.5 24.0 8.5 20.3 206.9 105.4 17.4 156.9 537.2 64.0 14.0 16.2 79.5 0.0 17.6 31.7 67.2 5.6 187.3 1.9 34.5 8.0 138.3 67.3 45.4 92.1 176.9 136.3 207.4 60.5 6.8 34.0 1543.6 10.8 30.8 11.7 44.8 CTSO CTSO1 ENSG00000256043 "Cathepsin O" P43234 4 155921580-155953912 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "ASC TERT1: 37.1;HSkMC: 44.6;Karpas-707: 85.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002041 Approved "Intracellular and membrane" NA NA 25000 "Cluster 44: Non-specific - Transcription" "Cluster 85: Liver - Metabolism" "Cluster 2: Karpas-707 - Immune response" "Cluster 50: Fibroblasts - ECM organization" "HPA002041: AB_1078408" "unprognostic (3.96e-3)" "unprognostic (1.62e-2)" "unprognostic (1.03e-1)" "unprognostic (1.33e-2)" "unprognostic (9.10e-3)" "unprognostic (2.55e-1)" "unprognostic (3.80e-3)" "unprognostic (2.07e-1)" "unprognostic (6.62e-2)" "unprognostic (1.33e-1)" "unprognostic (2.20e-1)" "unprognostic (1.05e-1)" "unprognostic (7.55e-2)" "unprognostic (4.87e-3)" "unprognostic (4.73e-2)" "unprognostic (1.11e-1)" "unprognostic (1.79e-1)" 19.1 31.5 8.0 17.8 8.0 5.0 31.9 6.2 11.8 36.7 7.9 19.6 32.8 37.2 36.1 16.7 36.9 40.7 20.2 7.8 7.6 34.5 98.8 36.8 24.5 7.1 7.5 28.0 19.9 24.5 9.6 41.2 6.9 29.8 23.2 5.2 22.1 32.2 6.7 10.0 34.0 30.7 7.0 39.7 15.5 9.4 7.4 14.1 34.5 17.8 17.9 28.0 15.4 7.6 0.8 0.6 4.1 3.7 17.3 37.1 0.2 1.6 18.3 3.3 5.7 0.4 14.4 0.2 1.2 6.8 1.2 0.1 0.2 0.1 2.6 1.6 0.1 0.4 0.5 0.2 18.1 1.4 0.2 44.6 3.5 2.2 1.8 25.6 3.5 0.7 0.3 85.8 11.7 0.7 1.1 0.4 0.7 0.6 0.7 4.8 0.5 1.0 16.8 7.5 0.5 4.3 2.4 9.3 2.3 2.0 4.2 2.6 3.0 13.3 0.7 0.4 2.3 8.3 0.2 0.2 24.4 0.3 18.6 5.3 0.9 0.6 1.2 0.7 3.0 1.2 1.4 0.8 0.4 1.5 1.6 2.0 0.7 3.0 0.9 1.0 3.3 1.4 8.0 8.0 6.2 11.8 7.8 7.6 7.1 7.5 6.9 7.0 7.4 7.6 29.3 38.5 20.8 15.0 19.9 10.5 13.1 11.3 12.0 10.4 20.1 13.0 5.0 44.3 14.3 25.8 2.1 20.5 19.6 15.6 13.7 24.6 0.4 20.9 34.6 28.2 6.7 8.6 1.7 20.7 7.7 51.5 8.6 27.3 8.8 25.0 43.2 58.1 16.3 5.0 1.7 7.9 8.2 29.2 23.7 1.5 30.4 21.4 30.2 7.5 26.5 17.0 22.6 36.7 5.4 12.7 6.3 25.2 7.0 17.5 21.1 10.7 14.5 1.9 19.7 34.0 24.6 0.3 2.1 5.9 9.1 10.5 14.5 14.3 6.6 9.5 CTSS ENSG00000163131 "Cathepsin S" P25774 1 150730079-150765957 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 137.0;lymphoid tissue: 164.8" "Cell type enhanced" "Detected in many" "Hofbauer cells: 698.6;Kupffer cells: 2230.8;Macrophages: 1316.2;monocytes: 2312.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "classical monocyte: 2483.4" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "CAPAN-2: 81.6;HMC-1: 187.5;U-698: 387.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000460, HPA002988" Supported Approved Vesicles "Intracellular and membrane" NA NA 23000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 64: Macrophages - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Vesicles "CAB000460: , HPA002988: AB_1078409" "unprognostic (7.81e-2)" "unprognostic (9.04e-2)" "unprognostic (3.23e-2)" "unprognostic (3.93e-2)" "unprognostic (1.52e-1)" "unprognostic (1.12e-2)" "unprognostic (1.11e-1)" "unprognostic (1.23e-1)" "unprognostic (1.59e-1)" "unprognostic (6.00e-3)" "unprognostic (1.46e-1)" "unprognostic (3.89e-1)" "unprognostic (6.24e-2)" "unprognostic (7.50e-2)" "unprognostic (4.14e-2)" "unprognostic (2.13e-1)" "unprognostic (2.47e-3)" 40.0 16.7 4.0 87.8 4.5 137.0 20.3 4.8 7.1 9.4 8.0 83.6 60.2 7.8 5.7 16.5 17.8 29.1 10.6 3.4 5.5 9.3 40.4 88.4 71.7 11.8 8.0 4.9 11.3 2.3 4.7 23.6 11.2 9.1 59.4 3.4 23.9 7.3 4.1 7.1 64.6 16.3 7.7 164.8 42.6 3.8 10.4 20.1 11.5 9.0 38.5 42.9 10.0 16.1 3.7 10.9 0.2 0.3 1.2 1.4 0.7 0.4 8.6 0.9 1.3 1.2 81.6 44.3 5.7 1.2 15.3 2.1 0.2 0.7 0.5 26.9 0.2 29.0 1.1 0.8 0.2 33.6 187.5 2.6 0.1 6.6 1.5 0.5 6.3 0.6 3.4 45.0 2.4 0.3 0.4 22.5 0.2 0.1 0.3 14.9 4.6 49.8 10.7 8.7 0.3 0.4 1.1 2.3 0.8 0.3 0.4 49.8 9.1 6.2 1.3 0.8 1.2 27.8 2.2 387.3 28.5 35.2 2.3 20.9 2483.4 218.0 41.3 1735.3 51.1 139.5 46.6 50.9 571.0 138.8 45.0 40.8 1022.2 41.8 1655.1 106.8 77.4 2577.6 4.0 4.5 4.8 7.1 3.4 5.5 11.8 8.0 11.2 7.7 10.4 16.1 37.6 109.0 158.7 1.6 255.3 17.0 31.3 72.0 4.6 2.3 21.0 8.9 5.3 74.4 143.4 42.3 12.5 3.7 198.0 549.2 0.0 183.6 6.6 126.9 8.6 44.1 42.4 22.5 10.3 177.0 5.7 34.4 71.9 39.0 106.8 9.5 60.3 30.6 698.6 0.0 9.5 205.7 73.2 2230.8 316.4 3.0 5.3 1316.2 56.9 27.2 2312.9 0.5 137.0 0.5 0.9 200.9 466.5 2.2 121.4 20.6 210.8 4.7 488.9 4.9 19.7 5.6 13.3 0.2 0.5 12.4 15.5 6.2 108.9 66.0 237.8 113.3 CTSV "CTSL2, CTSU" ENSG00000136943 "Cathepsin V" O60911 9 97029677-97156556 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 10 "lymphoid tissue: 643.6" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 63.7;Cytotrophoblasts: 122.3;Extravillous trophoblasts: 153.0;Granulosa cells: 54.2;Syncytiotrophoblasts: 67.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Immune cell enriched" "Detected in some" 4 "plasmacytoid DC: 15.1" "Lineage enriched" "Detected in many" 4 "dendritic cells: 15.1" "Group enriched" "Detected in many" 8 "BEWO: 592.6;SuSa: 739.0" "Low region specificity" "Detected in all" CAB017112 Uncertain Approved "Nucleoplasm,Nucleoli fibrillar center,Plasma membrane,Cytosol" "Intracellular and membrane" NA NA 370000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 63: T-cells - Adaptive immune response" "Cluster 28: BEWO - Transcription regulation" "Cluster 38: Extravillous trophoblasts - Unknown function" "Nucleoli fibrillar center, Cytosol" "Nucleoplasm, Plasma membrane" "CAB017112: " "unprognostic (2.40e-1)" "unprognostic (2.74e-2)" "unprognostic (1.50e-1)" "prognostic favorable (8.41e-4)" "unprognostic (7.29e-2)" "unprognostic (5.59e-2)" "prognostic unfavorable (2.83e-5)" "unprognostic (7.04e-3)" "unprognostic (6.06e-2)" "unprognostic (1.39e-2)" "prognostic unfavorable (2.87e-4)" "unprognostic (1.86e-2)" "unprognostic (1.78e-1)" "unprognostic (2.41e-2)" "unprognostic (1.33e-1)" "unprognostic (3.04e-3)" "prognostic unfavorable (2.39e-4)" 0.2 0.2 0.6 0.3 0.7 0.3 5.8 0.8 1.6 43.1 0.8 2.9 1.1 2.8 1.7 19.8 1.3 0.5 0.1 0.6 0.5 21.3 0.2 0.9 0.1 0.7 0.6 0.2 2.1 1.4 1.5 16.8 0.6 0.7 3.2 17.2 9.4 0.1 0.7 52.5 0.4 0.8 0.5 0.2 2.8 65.8 0.6 643.6 1.3 0.1 6.0 0.4 20.1 1.0 37.1 5.2 12.1 33.1 0.6 0.0 592.6 0.5 0.0 7.1 4.7 81.0 37.7 0.3 2.8 0.5 50.5 67.2 58.8 43.9 9.7 0.1 4.4 0.8 1.9 3.1 0.2 0.1 3.3 0.0 9.2 1.5 0.8 0.9 2.4 8.5 0.5 0.2 14.4 15.2 0.9 0.3 76.2 78.9 10.7 0.0 27.3 0.1 11.4 3.7 2.4 3.6 39.1 13.1 13.2 739.0 21.1 3.2 0.0 1.0 23.6 0.2 3.5 5.7 20.6 0.8 1.6 0.4 4.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.1 0.1 0.0 0.2 3.3 0.0 15.1 0.0 0.1 0.6 0.7 0.8 1.6 0.6 0.5 0.7 0.6 0.6 0.5 0.6 1.0 0.9 0.0 1.1 0.3 0.9 30.3 13.0 63.7 19.9 4.6 13.1 9.9 1.3 0.0 17.4 1.8 10.4 122.3 6.9 4.7 1.9 1.8 2.6 15.0 2.9 1.8 1.8 0.0 0.6 0.8 153.0 3.2 0.0 24.0 0.0 54.2 0.4 0.0 13.6 0.0 0.9 1.5 10.2 0.8 3.0 8.2 4.1 2.4 0.0 0.0 0.2 6.5 0.0 0.0 3.5 0.5 10.5 1.2 0.0 8.1 0.1 22.1 4.2 36.6 6.6 1.4 3.6 46.7 33.7 8.2 11.9 67.3 0.5 0.7 4.2 8.4 CTSW ENSG00000172543 "Cathepsin W" P56202 11 65879809-65883741 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 116.3;lymphoid tissue: 42.4" "Group enriched" "Detected in many" 9 "dendritic cells: 717.8;NK-cells: 867.2;T-cells: 352.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Group enriched" "Detected in all" 8 "gdT-cell: 1376.3;MAIT T-cell: 869.4;memory CD8 T-cell: 892.8;naive CD8 T-cell: 636.3;NK-cell: 2276.1" "Group enriched" "Detected in all" 39 "NK-cells: 2276.1;T-cells: 1376.3" "Group enriched" "Detected in some" 22 "HEL: 156.7;NB-4: 363.4" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "CAB016345, HPA066903" Enhanced "Intracellular and membrane" NA NA 270000 "Cluster 48: NK-cells - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 24: NB-4 - Immune response" "Cluster 63: NK-cells & T-cells - Immune response" "CAB016345: AB_626813, HPA066903: " "prognostic favorable (3.06e-4)" "unprognostic (2.06e-2)" "unprognostic (2.71e-2)" "prognostic favorable (8.36e-6)" "unprognostic (1.21e-1)" "prognostic favorable (9.89e-4)" "unprognostic (5.69e-2)" "unprognostic (1.09e-2)" "unprognostic (1.25e-3)" "unprognostic (5.14e-3)" "unprognostic (2.83e-2)" "unprognostic (1.59e-1)" "prognostic unfavorable (8.84e-6)" "unprognostic (3.86e-2)" "unprognostic (3.78e-1)" "unprognostic (1.26e-1)" "unprognostic (4.01e-3)" 5.1 2.9 0.8 12.9 0.9 116.3 3.7 1.8 1.6 2.6 0.6 5.6 6.1 6.7 2.8 3.1 4.0 6.2 2.9 0.8 0.9 2.1 6.5 24.0 29.5 1.6 0.7 2.4 1.8 0.5 1.1 3.3 1.2 2.1 6.3 0.0 9.1 3.9 1.3 2.7 6.1 2.7 1.2 42.4 8.3 1.2 1.1 7.8 3.2 0.4 13.9 8.6 2.5 1.1 0.1 0.0 0.1 0.0 0.4 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.2 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.4 0.1 0.0 156.7 0.3 0.0 0.0 11.8 0.4 0.0 0.0 0.0 0.1 0.0 0.0 5.0 0.0 9.1 0.2 0.2 1.9 363.4 0.1 0.0 0.1 0.1 0.0 0.3 0.0 0.1 0.0 0.2 0.1 0.0 1.1 0.0 0.0 5.6 0.1 0.0 0.1 0.4 0.1 0.3 0.5 0.0 0.2 9.9 0.3 46.4 3.4 4.8 1376.3 4.0 869.4 5.1 145.3 892.8 37.6 3.7 86.0 636.3 25.7 2276.1 5.4 23.3 23.7 809.3 0.8 0.9 1.8 1.6 0.8 0.9 1.6 0.7 1.2 1.2 1.1 1.1 5.1 0.0 4.2 0.0 9.7 4.6 0.4 0.0 1.8 0.0 2.3 2.2 0.4 2.8 1.4 0.0 0.0 0.4 717.8 0.3 0.0 0.3 2.0 0.9 0.9 1.9 0.0 44.1 0.0 0.0 0.2 4.0 12.8 1.1 71.7 0.1 5.7 1.6 1.9 0.0 0.0 0.2 0.0 5.6 34.1 11.1 0.0 9.9 17.8 0.0 6.1 0.0 867.2 0.0 0.2 0.0 0.0 0.0 57.7 0.3 0.0 1.1 0.8 0.0 0.0 1.6 1.9 0.3 1.2 0.8 6.3 0.3 352.6 0.1 0.3 0.3 CTSZ CTSX ENSG00000101160 "Cathepsin Z" Q9UBR2 20 58985686-59008238 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hofbauer cells: 1078.9;Langerhans cells: 983.5;Macrophages: 652.3;monocytes: 723.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 542.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025114, HPA049876, HPA053504" Supported Supported Vesicles "Intracellular and membrane" NA NA 88000000 "Cluster 49: Eosinophils - Unknown function" "Cluster 64: Macrophages - Immune response" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 41: Macrophages - Immune response" Vesicles "CAB025114: , HPA049876: AB_2680927, HPA053504: AB_2682172" "unprognostic (7.30e-2)" "unprognostic (3.98e-2)" "unprognostic (4.07e-2)" "unprognostic (1.11e-3)" "unprognostic (8.25e-3)" "unprognostic (1.15e-1)" "unprognostic (4.12e-2)" "unprognostic (6.59e-2)" "unprognostic (1.59e-1)" "unprognostic (1.22e-1)" "unprognostic (1.33e-1)" "unprognostic (5.33e-2)" "prognostic unfavorable (5.72e-5)" "unprognostic (1.96e-1)" "unprognostic (6.92e-2)" "unprognostic (1.19e-1)" "unprognostic (2.04e-1)" 178.1 117.8 18.9 208.8 21.8 99.8 137.0 20.5 32.0 92.1 59.6 173.8 215.4 87.3 13.4 53.1 88.9 89.4 152.6 15.3 33.9 125.6 356.4 233.3 271.5 31.6 23.5 71.0 89.4 91.8 112.5 118.7 27.9 87.8 77.1 4.1 181.0 66.3 58.7 58.5 226.0 97.9 26.2 234.4 88.2 24.6 47.2 57.1 122.3 54.6 91.3 146.3 69.0 45.4 205.4 139.8 1.1 1.1 114.2 124.2 106.5 291.0 225.4 187.4 152.3 231.6 324.6 96.5 213.9 542.1 0.5 160.1 51.4 257.5 30.2 362.1 13.6 80.3 169.0 0.8 137.3 9.0 331.0 130.9 127.8 83.1 62.4 34.8 281.3 1.1 74.0 48.7 90.0 1.1 1.3 70.6 11.5 43.5 158.2 2.9 0.4 135.7 86.3 25.5 2.7 1.7 222.4 258.4 0.8 19.5 131.9 148.4 420.5 1.4 161.8 209.0 2.0 253.7 172.0 18.2 2.8 207.9 0.4 1.2 1.5 1.6 0.6 1.4 0.4 1.1 0.6 0.4 1.1 1.4 0.7 0.8 1.6 0.5 2.9 1.8 0.3 0.7 18.9 21.8 20.5 32.0 15.3 33.9 31.6 23.5 27.9 26.2 47.2 45.4 132.1 16.0 5.3 5.9 119.8 50.3 64.5 33.8 24.5 6.7 67.4 99.6 21.7 62.9 14.1 71.7 0.0 38.2 104.8 303.6 23.5 176.0 3.5 52.9 47.7 82.2 27.1 63.3 5.3 42.4 104.8 71.5 19.4 71.3 10.8 68.4 62.8 363.0 1078.9 11.8 3.0 56.6 26.4 334.0 983.5 6.0 13.1 652.3 101.4 23.4 723.6 58.6 21.6 2.5 2.5 82.6 217.5 13.9 96.3 50.6 339.8 90.0 18.8 5.0 46.0 67.5 74.5 3.7 4.8 14.5 41.5 41.3 33.4 3.3 99.7 52.7 CYLD "CYLD1, KIAA0849, USPL2" ENSG00000083799 "CYLD lysine 63 deubiquitinase" Q9NQC7 16 50742050-50801935 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Immunity, Innate immunity, Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 94.3" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 136.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011713, HPA050095" Approved Supported "Nucleoplasm,Centriolar satellite" Yes No "Cluster 10: Basophils - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 44: HDLM-2 - Immune response" "Cluster 24: Non-specific - Transcription regulation" "Centriolar satellite" Nucleoplasm "CAB011713: AB_731794, HPA050095: AB_2681013" "unprognostic (9.83e-2)" "unprognostic (1.17e-2)" "unprognostic (5.01e-2)" "unprognostic (2.83e-2)" "unprognostic (3.84e-1)" "unprognostic (5.06e-2)" "unprognostic (3.87e-2)" "unprognostic (3.24e-2)" "unprognostic (9.46e-2)" "unprognostic (1.11e-1)" "unprognostic (1.18e-2)" "unprognostic (2.32e-1)" "unprognostic (1.03e-1)" "unprognostic (1.07e-1)" "unprognostic (3.43e-2)" "unprognostic (6.83e-2)" "unprognostic (8.42e-2)" 14.3 22.0 23.9 38.8 23.5 94.3 13.6 17.9 18.2 13.0 22.3 16.3 16.1 15.1 12.1 23.3 11.0 20.5 20.1 17.3 23.3 14.2 21.0 21.5 53.4 21.3 27.8 15.4 15.2 23.0 15.4 15.4 23.6 16.3 19.3 22.0 18.9 16.0 34.3 15.2 16.2 16.8 21.6 39.0 19.9 38.3 32.7 35.6 24.9 20.5 48.4 24.1 12.9 24.2 26.9 8.3 9.4 10.6 14.3 21.0 8.7 39.1 56.7 39.9 23.4 6.9 12.5 30.7 13.7 38.3 43.4 10.3 11.3 23.7 58.7 136.6 16.6 15.5 15.3 5.8 29.1 15.4 69.5 23.0 18.6 48.1 50.1 37.7 16.3 21.3 6.6 26.1 56.4 4.0 14.4 22.3 10.1 8.5 13.3 13.4 18.8 29.4 12.9 9.1 12.0 9.2 33.1 11.2 9.8 14.3 11.0 18.9 18.6 67.2 15.4 23.4 15.9 68.0 68.4 33.2 49.3 16.7 14.7 64.6 15.2 38.3 18.1 17.7 21.8 17.2 27.1 24.5 18.3 11.1 24.4 19.4 32.3 25.7 18.8 11.0 37.3 19.5 23.9 23.5 17.9 18.2 17.3 23.3 21.3 27.8 23.6 21.6 32.7 24.2 28.8 44.8 31.8 31.6 87.7 120.1 59.5 32.2 40.9 89.2 35.5 26.0 34.4 21.5 32.9 18.4 93.8 6.8 84.1 28.3 5.9 20.0 48.2 22.5 24.9 36.0 31.1 26.1 51.9 19.1 4.4 37.3 22.4 47.1 80.5 21.4 27.8 25.5 21.5 67.3 54.7 10.7 30.5 40.0 127.6 31.3 25.4 66.4 74.7 57.1 63.7 23.3 70.0 51.8 119.2 18.0 22.4 21.1 79.7 66.4 15.4 13.9 23.3 48.3 6.6 54.2 30.5 59.2 15.2 64.3 155.6 4.1 119.5 21.3 14.8 66.7 DNPEP "ASPEP, DAP" ENSG00000123992 "Aspartyl aminopeptidase" Q9ULA0 2 219372043-219400022 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 364.4;Late spermatids: 462.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036398, HPA044860" Enhanced Supported Cytosol NA NA 2700000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 28: BEWO - Transcription regulation" "Cluster 10: Non-specific - Unknown function" Cytosol "HPA036398: AB_10970915, HPA044860: AB_10961275" "unprognostic (3.71e-1)" "unprognostic (6.45e-2)" "unprognostic (1.26e-1)" "unprognostic (1.05e-2)" "unprognostic (1.55e-2)" "unprognostic (2.75e-1)" "unprognostic (2.54e-3)" "unprognostic (3.34e-2)" "unprognostic (2.44e-1)" "unprognostic (3.49e-2)" "unprognostic (1.61e-1)" "unprognostic (6.13e-2)" "unprognostic (1.67e-1)" "unprognostic (5.63e-3)" "unprognostic (3.49e-1)" "unprognostic (2.50e-1)" "unprognostic (1.85e-3)" 25.8 18.9 15.4 25.0 15.8 18.0 23.6 14.8 18.6 24.9 14.7 34.5 56.5 22.4 21.5 25.1 25.1 22.6 39.9 16.2 16.9 22.1 32.0 27.6 23.4 15.8 15.0 30.2 27.2 25.8 13.0 37.1 15.2 22.6 30.8 9.5 26.2 24.4 64.5 31.7 56.2 19.9 16.0 24.7 25.4 58.5 17.4 17.5 15.2 46.4 16.2 29.6 21.6 14.7 47.5 25.8 15.4 45.7 39.7 32.2 122.0 23.0 46.5 59.3 62.5 72.6 61.2 27.2 48.7 49.5 76.0 45.0 18.6 53.6 21.3 56.4 12.5 46.6 25.0 79.8 107.2 38.9 32.2 54.4 55.4 61.8 50.2 37.9 41.2 38.6 53.8 45.3 31.0 103.7 60.8 44.5 25.5 67.7 15.1 77.2 35.7 36.5 33.0 74.0 19.1 26.0 27.1 86.5 34.5 26.9 25.8 43.3 23.5 55.4 46.1 31.4 33.7 49.6 31.8 21.3 80.0 37.7 24.1 8.7 17.2 7.3 16.1 19.7 18.8 13.2 13.2 18.3 20.8 16.2 14.0 18.7 1.6 21.2 17.0 7.2 16.6 14.8 15.4 15.8 14.8 18.6 16.2 16.9 15.8 15.0 15.2 16.0 17.4 14.7 43.1 12.8 18.2 8.8 35.6 38.6 74.1 55.1 52.9 19.3 41.2 36.7 33.6 55.8 27.2 25.8 33.3 90.4 26.7 70.4 49.0 62.9 364.4 16.5 36.5 41.8 48.0 19.8 3.1 66.3 96.9 43.4 29.0 19.6 24.1 39.1 30.4 47.9 51.0 10.1 5.2 110.3 38.7 31.5 26.8 462.0 52.5 26.2 32.0 4.7 53.0 29.8 45.3 3.0 3.3 52.3 75.6 41.0 38.3 113.1 202.6 79.6 16.3 37.6 26.3 31.9 120.0 20.1 20.1 43.4 44.8 66.4 34.1 36.9 70.9 74.6 DPP10 "DPL2, DPPY, DPRP3" ENSG00000175497 "Dipeptidyl peptidase like 10" Q8N608 2 114442299-115845780 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Asthma "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "adrenal gland: 10.7;brain: 20.2;pancreas: 17.3" "Cell type enhanced" "Detected in many" "Astrocytes: 4634.9;Excitatory neurons: 3067.4;Inhibitory neurons: 3258.7;Oligodendrocyte precursor cells: 990.7" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 4.1;HAP1: 6.2;HMC-1: 4.3;JURKAT: 3.4;NTERA-2: 3.7;RT4: 6.7;SCLC-21H: 9.7;SH-SY5Y: 3.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA048767 Uncertain NA NA "Cluster 22: Non-specific - Unknown function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA048767: AB_2680515" "unprognostic (1.19e-1)" "unprognostic (2.55e-2)" "unprognostic (1.84e-1)" "unprognostic (1.77e-2)" "unprognostic (1.29e-1)" "unprognostic (2.03e-2)" "unprognostic (6.59e-2)" "unprognostic (2.92e-1)" "unprognostic (5.35e-2)" "unprognostic (2.95e-2)" "unprognostic (1.23e-1)" "unprognostic (1.03e-2)" "unprognostic (8.33e-2)" "unprognostic (7.61e-2)" "unprognostic (4.22e-2)" 0.2 10.7 12.4 0.3 20.2 0.1 0.0 0.0 16.6 0.3 0.0 2.2 1.2 0.4 0.0 0.0 0.1 0.8 0.1 19.3 0.5 0.2 0.1 0.2 0.0 1.9 3.1 0.0 17.3 0.0 0.8 0.8 2.0 0.0 2.8 4.1 0.2 0.0 0.0 0.1 1.2 0.8 4.5 0.0 1.0 1.0 6.0 0.0 0.6 0.0 0.0 0.3 0.0 11.7 0.0 0.0 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.1 0.0 0.0 0.0 0.0 0.0 3.7 0.0 0.0 0.0 0.0 0.0 0.0 6.7 9.7 3.9 0.0 0.0 0.0 1.1 0.0 0.4 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.4 20.2 0.0 16.6 19.3 0.5 1.9 3.1 2.0 4.5 6.0 11.7 0.0 0.0 0.0 4634.9 0.0 0.0 0.0 0.0 0.6 21.7 0.0 0.0 1.5 4.3 0.6 0.0 0.0 1.5 0.0 2.3 0.0 0.0 12.4 0.1 0.1 0.1 4.2 2.1 3067.4 2.7 10.2 0.5 0.0 0.3 0.0 5.8 0.7 0.0 0.3 5.0 3258.7 1.4 0.0 0.0 0.0 5.7 0.3 0.0 1.8 58.1 0.0 1.4 0.0 990.7 48.3 0.8 1.9 0.0 0.0 0.0 0.2 0.2 0.0 0.7 0.0 0.0 0.1 1.6 2.6 0.3 0.0 4.4 0.0 0.4 3.2 0.0 DPP3 ENSG00000254986 "Dipeptidyl peptidase 3" Q9NY33 11 66480013-66509657 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Rod photoreceptor cells: 72.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035780, HPA035781" Approved Supported Cytosol NA NA 3200000 "Cluster 27: Non-specific - Gene expression" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 46: Photoreceptor cells - Phototransduction" Cytosol "HPA035780: AB_2674778, HPA035781: AB_10669529" "unprognostic (5.74e-2)" "unprognostic (1.16e-3)" "unprognostic (2.62e-3)" "unprognostic (4.77e-2)" "unprognostic (1.99e-1)" "unprognostic (5.44e-3)" "unprognostic (1.67e-3)" "unprognostic (1.25e-3)" "unprognostic (1.73e-2)" "unprognostic (9.87e-2)" "unprognostic (1.02e-2)" "unprognostic (3.87e-1)" "unprognostic (5.85e-2)" "prognostic favorable (1.34e-4)" "unprognostic (1.81e-2)" "unprognostic (3.43e-1)" "unprognostic (5.66e-2)" 11.6 17.5 8.2 21.4 9.1 20.7 11.2 10.2 10.4 11.0 5.4 30.2 24.8 11.7 7.8 23.5 9.8 14.5 10.3 8.4 8.9 17.1 18.6 14.3 21.8 10.2 8.8 6.8 17.3 11.9 8.7 14.3 10.8 14.4 26.3 15.9 18.8 12.9 26.5 13.6 20.5 16.2 8.6 15.4 19.2 9.8 10.2 18.6 11.7 7.4 23.3 17.3 13.5 9.9 84.1 71.6 32.5 36.3 26.4 28.3 50.4 46.5 61.8 61.4 40.7 90.8 68.4 48.7 154.0 52.9 52.2 73.6 52.1 57.0 39.4 92.5 23.8 63.1 32.1 54.2 40.7 77.6 101.1 40.5 54.5 46.2 22.8 26.5 47.8 50.1 45.1 28.2 56.7 95.3 91.0 78.7 55.5 82.0 43.2 63.1 32.7 79.6 52.6 71.7 61.1 52.2 39.7 45.6 62.5 30.3 70.8 44.7 50.1 36.5 39.4 40.7 46.2 23.3 46.6 56.6 48.5 36.5 45.9 20.7 18.8 21.3 21.4 40.0 13.3 11.5 15.8 17.7 32.3 11.1 9.4 13.9 3.2 30.8 27.9 22.5 29.6 17.7 8.2 9.1 10.2 10.4 8.4 8.9 10.2 8.8 10.8 8.6 10.2 9.9 5.8 16.0 13.2 6.8 11.6 6.0 17.4 34.8 8.6 11.4 7.1 3.8 3.0 10.0 27.0 23.9 10.4 46.9 11.5 41.6 13.7 45.6 24.6 8.7 6.2 10.5 18.6 3.4 3.4 61.3 34.2 7.4 29.0 11.5 1.3 9.9 3.6 14.7 37.4 6.7 4.0 19.5 63.1 7.9 9.0 7.0 2.1 10.8 16.0 3.7 31.3 21.6 18.6 4.5 5.6 40.8 25.2 5.3 15.7 11.0 26.4 28.7 17.3 72.9 13.1 4.4 16.2 8.8 20.7 14.4 6.0 36.0 13.1 20.1 29.5 19.5 DPP4 "ADCP2, CD26, DPPIV" ENSG00000197635 "Dipeptidyl peptidase 4" P27487 2 161992245-162074394 "CD markers, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Cell adhesion" "Aminopeptidase, Hydrolase, Protease, Receptor, Serine protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 137.9;parathyroid gland: 155.7;placenta: 134.1;prostate: 107.3" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 140.3;Proximal enterocytes: 291.1;Proximal tubular cells: 101.4;Syncytiotrophoblasts: 172.0" "Cancer enhanced" "Detected in all" "prostate cancer: 55.2" "Not detected" "Not detected" "Immune cell enhanced" "Detected in many" "MAIT T-cell: 52.3" "Lineage enriched" "Detected in many" 10 "T-cells: 52.3" "Cell line enhanced" "Detected in many" "ASC diff: 194.4;ASC TERT1: 212.6;BJ hTERT+: 207.0;RPTEC TERT1: 263.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "CAB045970, HPA068778, HPA071236" Enhanced "Secreted to blood" NA NA 190000000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "CAB045970: AB_11140529, HPA068778: , HPA071236: " "unprognostic (4.47e-2)" "unprognostic (4.47e-2)" "unprognostic (8.89e-2)" "unprognostic (3.36e-1)" "unprognostic (7.25e-2)" "unprognostic (5.40e-2)" "unprognostic (2.78e-1)" "unprognostic (3.54e-2)" "unprognostic (3.58e-1)" "unprognostic (4.73e-1)" "unprognostic (2.36e-1)" "prognostic unfavorable (1.98e-4)" "prognostic favorable (1.35e-6)" "unprognostic (4.68e-2)" "unprognostic (6.33e-2)" "prognostic favorable (4.99e-4)" "unprognostic (1.21e-2)" 13.3 3.1 0.2 5.3 0.2 0.6 8.4 0.1 0.6 10.9 0.1 14.6 107.0 3.6 4.0 3.0 7.4 6.7 3.4 0.2 0.1 94.9 57.2 16.0 5.8 0.2 0.2 3.5 3.5 155.7 0.1 134.1 0.3 107.3 16.9 0.1 84.5 23.5 1.5 5.7 137.9 3.0 0.1 11.2 7.6 1.3 0.8 12.4 5.0 3.9 4.4 5.7 3.5 0.4 0.2 0.2 1.0 0.0 194.4 212.6 0.6 37.7 207.0 10.9 37.2 38.0 1.0 0.0 13.6 71.0 30.2 1.1 0.4 0.0 6.2 12.3 0.0 0.0 0.0 57.1 77.0 0.0 0.0 22.0 0.1 66.3 0.5 9.1 6.6 0.7 0.0 0.0 3.6 0.0 3.6 0.5 2.0 1.3 72.7 0.0 0.0 0.6 263.3 0.0 0.1 0.4 0.0 0.0 0.0 4.4 0.0 0.3 37.0 21.8 1.1 0.7 0.0 0.0 0.0 0.0 22.5 0.0 0.0 0.0 0.0 0.0 6.6 0.0 52.3 0.2 16.2 10.7 1.2 0.0 15.7 6.6 0.4 5.3 0.0 4.0 2.0 4.7 0.2 0.2 0.1 0.6 0.2 0.1 0.2 0.2 0.3 0.1 0.8 0.4 10.8 6.4 26.0 0.3 2.1 4.1 0.4 0.1 0.0 1.8 0.2 0.8 3.3 12.8 2.8 14.7 10.4 140.3 10.4 27.4 1.9 3.0 15.0 2.3 7.1 9.4 55.2 0.4 31.6 0.0 59.1 35.3 2.0 68.0 13.9 5.3 9.3 34.5 14.5 0.0 6.3 16.4 0.0 0.9 7.6 7.9 0.0 4.8 5.4 3.7 1.1 0.0 1.0 2.5 0.7 1.4 23.8 0.0 2.1 32.7 291.1 101.4 2.2 0.1 0.0 2.1 1.5 4.0 1.1 0.1 4.1 172.0 25.8 29.2 29.1 0.3 DPP6 "DPL1, DPPX" ENSG00000130226 "Dipeptidyl peptidase like 6" P42658 7 153887097-154894285 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Disease variant, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 54.0;endometrium 1: 58.2" "Group enriched" "Detected in many" 4 "Excitatory neurons: 673.4;Inhibitory neurons: 1195.9;Oligodendrocyte precursor cells: 1947.8" "Cancer enriched" "Detected in some" 11 "glioma: 12.1" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 9 "NTERA-2: 11.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA050509 Enhanced Supported NA NA "Cluster 42: Non-specific - Transcription" "Cluster 57: Non-specific - Angiogenesis" "Cluster 5: NTERA-2 - Transcription" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA050509: AB_2681150" "unprognostic (1.29e-1)" "unprognostic (3.55e-2)" "unprognostic (5.68e-2)" "unprognostic (5.86e-2)" "unprognostic (1.53e-2)" "unprognostic (2.28e-1)" "unprognostic (2.73e-1)" "unprognostic (5.83e-4)" "unprognostic (1.55e-1)" "unprognostic (2.98e-1)" "unprognostic (7.45e-3)" "unprognostic (4.04e-3)" "unprognostic (2.94e-3)" "unprognostic (1.85e-4)" "unprognostic (1.05e-1)" "unprognostic (4.61e-3)" "unprognostic (6.11e-2)" 0.6 8.2 16.5 0.2 24.5 0.1 0.5 32.0 34.5 5.8 0.0 19.8 0.5 58.2 2.5 0.3 5.2 0.1 0.2 42.7 21.6 5.3 0.0 1.4 0.1 54.0 24.5 0.7 3.9 0.0 10.8 0.2 53.1 0.3 1.6 11.1 0.1 8.9 6.0 3.6 3.4 19.9 8.6 4.7 7.8 7.3 32.2 1.9 17.1 0.9 0.0 0.3 1.1 14.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.3 0.2 11.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 1.1 0.0 0.1 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.6 0.0 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.3 0.2 0.2 0.1 0.1 0.0 16.5 24.5 32.0 34.5 42.7 21.6 54.0 24.5 53.1 8.6 32.2 14.8 0.1 0.0 0.0 147.9 0.0 3.3 0.4 0.0 0.0 27.0 0.4 1.3 7.4 0.0 1.3 0.0 0.0 0.0 0.0 0.1 0.0 0.1 13.4 0.9 21.6 0.4 10.3 0.0 673.4 4.0 0.0 2.1 0.0 0.5 0.0 0.0 0.0 0.0 0.2 32.0 1195.9 0.4 0.0 0.0 0.0 18.4 1.2 0.2 16.0 22.5 0.0 17.1 0.0 1947.8 290.8 0.3 0.0 3.8 0.0 0.1 0.1 0.4 0.8 6.1 0.0 0.7 0.9 1.2 4.0 0.0 1.6 0.0 0.2 0.0 0.0 0.2 DPP7 "DPP2, DPPII" ENSG00000176978 "Dipeptidyl peptidase 7" Q9UHL4 9 137110546-137115177 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Aminopeptidase, Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 997.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "RPMI-8226: 232.0;THP-1: 218.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021282, CAB025541, HPA059381" Enhanced Supported "Golgi apparatus,Vesicles" "Secreted - unknown location" NA NA 1600000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 18: Non-specific - Mitochondria" "Cluster 25: RPMI-8226 - Immune response" "Cluster 25: Spermatids - Spermatogenesis" "Golgi apparatus, Vesicles" "CAB025541: , HPA021282: AB_1847673, HPA059381: AB_2683999" "unprognostic (1.15e-1)" "unprognostic (5.54e-2)" "prognostic unfavorable (6.07e-6)" "unprognostic (6.78e-3)" "unprognostic (1.25e-1)" "unprognostic (8.33e-2)" "unprognostic (7.49e-2)" "unprognostic (6.10e-2)" "unprognostic (2.28e-2)" "unprognostic (5.71e-3)" "prognostic favorable (8.31e-5)" "unprognostic (7.99e-2)" "unprognostic (1.46e-2)" "unprognostic (2.56e-2)" "unprognostic (1.72e-1)" "unprognostic (2.15e-1)" "unprognostic (1.02e-1)" 60.2 98.8 42.1 28.0 43.2 45.8 56.8 43.4 64.9 45.4 83.6 65.3 28.4 46.3 16.7 46.0 53.6 31.3 116.4 43.8 52.0 58.7 70.0 57.3 41.7 53.4 48.0 37.7 82.8 54.3 112.3 26.7 45.7 81.1 7.3 8.0 92.3 46.2 52.8 56.6 51.7 12.8 45.6 79.0 69.4 75.3 48.3 19.8 83.7 21.4 14.4 59.3 48.0 49.2 28.0 43.1 3.5 3.6 51.1 40.5 5.7 42.2 66.2 26.6 17.4 41.0 22.2 56.2 44.4 27.2 1.2 60.3 30.7 8.2 1.3 54.8 2.1 26.4 63.6 1.3 113.5 69.1 135.5 50.0 31.7 11.6 24.1 38.3 35.1 65.8 57.5 41.2 18.0 76.4 35.7 65.7 14.8 99.9 42.8 52.8 0.5 232.0 43.3 30.5 67.7 46.7 47.8 122.6 118.9 0.8 43.5 218.1 44.1 67.4 23.5 43.4 29.5 51.7 31.8 14.9 80.9 41.1 31.1 40.2 194.8 59.2 148.8 176.2 151.8 86.6 131.4 127.9 190.6 83.4 117.1 106.2 12.0 95.0 110.6 276.6 173.6 204.1 42.1 43.2 43.4 64.9 43.8 52.0 53.4 48.0 45.7 45.6 48.3 49.2 80.5 54.5 80.9 54.9 96.8 67.0 103.2 109.2 59.7 74.5 90.3 82.2 66.5 94.4 76.8 53.3 35.5 55.2 129.2 28.2 37.2 121.0 288.7 35.9 40.7 58.2 88.1 35.9 31.4 68.1 115.3 97.2 33.6 47.3 74.3 178.7 64.6 77.1 315.7 121.1 27.9 32.3 107.8 171.7 106.2 997.8 155.4 150.1 167.2 9.4 165.5 123.9 122.6 16.6 26.4 58.2 54.3 169.2 190.2 108.5 97.3 84.9 75.4 83.6 52.6 57.4 58.4 106.2 46.2 47.3 64.9 51.4 115.4 19.0 43.1 90.4 DPP8 "DP8, DPRP1, FLJ14920, FLJ20283, MGC26191, MSTP141" ENSG00000074603 "Dipeptidyl peptidase 8" Q6V1X1 15 65442463-65517704 "Enzymes, Plasma proteins, Predicted intracellular proteins" Apoptosis "Aminopeptidase, Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008706 Approved Supported Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 16: U-266 - Nucleosome" "Cluster 66: Spermatocytes - Spermatogenesis" Cytosol "HPA008706: AB_1078665" "unprognostic (3.65e-1)" "unprognostic (2.38e-2)" "unprognostic (2.15e-1)" "unprognostic (1.13e-1)" "unprognostic (1.24e-1)" "unprognostic (8.60e-2)" "unprognostic (2.98e-1)" "unprognostic (2.46e-1)" "unprognostic (2.52e-2)" "unprognostic (1.81e-1)" "unprognostic (4.09e-2)" "unprognostic (3.60e-2)" "unprognostic (1.99e-2)" "unprognostic (1.01e-1)" "unprognostic (7.58e-2)" "unprognostic (8.56e-2)" "unprognostic (2.59e-1)" 12.7 10.2 7.0 12.1 8.5 14.9 11.8 9.3 11.3 11.8 5.5 11.4 14.4 11.7 9.7 10.0 8.3 9.7 14.9 8.3 9.2 12.7 7.9 11.1 12.9 7.3 8.3 10.8 7.4 15.2 5.7 11.2 7.2 10.8 12.9 15.4 9.5 11.5 27.5 9.8 13.5 13.1 8.5 14.8 11.0 26.1 9.7 13.8 14.1 30.6 11.3 11.2 8.3 9.7 14.1 24.4 15.7 15.8 17.4 25.2 12.8 22.5 28.4 21.1 20.3 10.6 12.6 25.1 16.3 30.3 14.5 25.9 30.6 17.6 26.0 20.9 17.2 24.2 18.1 10.4 17.9 34.3 23.8 18.6 18.3 17.0 16.0 18.5 23.2 19.2 16.4 24.1 26.5 12.5 17.1 12.0 9.9 15.7 11.1 22.6 27.9 24.7 19.8 32.7 10.5 17.0 14.3 15.8 25.3 15.6 14.4 22.5 28.6 28.2 19.2 12.7 25.5 26.9 42.2 25.8 21.3 32.8 20.4 30.5 11.7 15.1 12.1 11.7 12.6 11.8 10.0 11.2 10.9 12.2 9.5 10.6 20.9 8.2 15.8 8.6 11.3 7.2 7.0 8.5 9.3 11.3 8.3 9.2 7.3 8.3 7.2 8.5 9.7 9.7 39.1 35.3 27.9 65.6 30.0 13.4 15.0 20.4 15.9 24.1 21.1 14.2 43.4 21.5 25.4 14.7 37.5 20.4 35.3 25.8 23.5 22.7 57.4 17.3 19.3 39.5 25.9 17.9 50.1 30.0 15.2 22.3 31.1 17.5 27.8 24.7 46.1 18.2 21.5 28.6 58.6 27.0 16.2 36.0 15.1 59.7 29.2 31.9 23.2 38.4 47.6 32.3 45.3 36.2 57.1 38.4 25.8 29.3 24.7 19.3 24.2 27.5 25.9 28.1 19.7 29.9 22.1 69.3 24.4 21.9 20.2 17.6 28.5 46.5 26.7 23.6 DPP9 ENSG00000142002 "Dipeptidyl peptidase 9" Q86TI2 19 4675224-4724673 "Enzymes, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HBEC3-KT: 203.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036059 Approved Supported Cytosol NA NA "Cluster 34: Basophils - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 30: Epithelial cell lines - Translation" "Cluster 52: Non-specific - Transcription" Cytosol "HPA036059: AB_10671240" "prognostic favorable (4.96e-4)" "unprognostic (4.16e-2)" "unprognostic (2.03e-1)" "prognostic favorable (6.21e-5)" "unprognostic (5.67e-2)" "unprognostic (8.30e-2)" "unprognostic (1.66e-1)" "unprognostic (1.23e-1)" "unprognostic (8.85e-2)" "unprognostic (6.38e-2)" "unprognostic (1.93e-1)" "unprognostic (3.39e-2)" "prognostic unfavorable (3.38e-8)" "prognostic favorable (7.72e-5)" "unprognostic (1.55e-1)" "unprognostic (4.22e-1)" "unprognostic (1.80e-1)" 19.6 16.2 12.2 24.5 13.8 32.8 19.4 12.9 13.7 20.1 25.0 24.2 20.1 20.3 5.9 24.5 16.3 13.5 32.2 13.2 11.7 16.9 57.2 27.4 24.9 14.8 14.3 17.3 20.6 10.1 12.7 12.9 14.3 18.9 13.8 9.5 17.7 12.8 71.0 23.8 26.3 15.3 12.3 28.4 21.1 9.0 16.1 17.9 16.9 23.0 17.1 23.2 20.2 15.4 77.5 60.4 17.6 27.5 26.2 36.3 31.7 44.3 58.5 73.1 47.4 54.3 58.2 36.5 32.8 57.7 49.1 51.7 35.9 203.9 44.5 47.3 34.8 26.8 33.6 47.2 40.0 47.2 55.8 27.9 46.6 114.4 67.2 62.2 66.8 25.0 37.4 78.3 64.1 21.2 54.2 30.0 36.0 30.4 89.0 34.0 37.4 42.4 38.3 52.5 24.8 22.2 38.2 67.8 29.5 18.1 18.8 38.2 54.5 64.9 28.0 101.6 89.6 54.6 62.3 36.8 63.4 53.7 55.7 10.8 7.1 7.7 10.6 8.3 7.9 8.0 4.7 8.5 7.1 4.8 4.5 7.3 3.7 11.4 6.5 3.3 9.7 7.7 12.2 13.8 12.9 13.7 13.2 11.7 14.8 14.3 14.3 12.3 16.1 15.4 21.8 28.9 25.8 14.4 18.8 7.9 13.6 10.2 10.8 18.6 12.2 12.3 14.6 10.0 11.2 3.7 37.5 11.7 22.7 37.4 3.9 12.4 2.0 12.7 14.6 19.4 12.5 7.6 10.1 12.8 18.3 10.7 36.2 22.8 17.1 13.3 17.2 39.5 19.0 23.5 10.2 21.3 6.1 20.4 17.6 3.9 9.9 22.0 5.4 16.9 42.2 9.0 25.7 7.5 13.7 26.6 28.4 9.4 32.9 15.6 20.1 5.1 9.5 30.8 19.7 21.7 12.4 7.5 6.9 12.4 5.5 15.6 21.2 12.8 20.6 16.7 ECE1 ECE ENSG00000117298 "Endothelin converting enzyme 1" P42892 1 21217247-21345572 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant, Hirschsprung disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 164.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 29.8" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HUVEC TERT2: 673.8;TIME: 588.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001490, HPA013616" Enhanced NA NA 1300000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA001490: AB_1078718, HPA013616: AB_1847963" "unprognostic (7.90e-2)" "unprognostic (1.01e-1)" "unprognostic (1.48e-1)" "unprognostic (1.99e-2)" "unprognostic (1.49e-2)" "unprognostic (1.46e-1)" "unprognostic (5.24e-2)" "unprognostic (1.23e-1)" "unprognostic (6.20e-2)" "unprognostic (1.92e-3)" "unprognostic (1.04e-1)" "unprognostic (2.56e-1)" "unprognostic (7.70e-2)" "unprognostic (3.55e-2)" "unprognostic (9.10e-2)" "unprognostic (1.97e-2)" "unprognostic (1.97e-2)" 87.3 123.2 26.5 47.7 29.4 48.1 79.4 23.0 30.1 61.4 12.6 71.0 30.1 42.4 10.0 26.7 46.9 36.8 70.9 21.3 33.7 38.1 54.0 72.1 35.7 34.4 25.7 71.0 91.8 125.0 47.4 66.5 30.4 53.1 34.7 14.7 33.6 25.1 19.8 34.3 46.1 42.3 21.2 48.5 43.3 22.7 28.1 21.1 51.4 33.2 34.9 58.8 43.8 27.5 93.0 60.1 77.9 38.3 111.0 116.4 44.1 135.4 236.8 72.9 66.6 44.1 275.8 34.0 323.6 138.8 157.7 38.4 32.6 64.9 63.5 83.0 27.2 48.7 89.9 34.8 144.3 7.1 11.8 61.6 74.3 112.6 55.8 199.2 673.8 27.6 10.0 17.7 62.9 19.4 14.6 11.4 23.2 26.3 46.5 17.5 45.0 49.2 114.0 17.0 26.4 63.1 134.3 79.2 57.4 42.5 55.9 20.2 588.7 160.7 77.9 73.3 79.9 26.4 49.0 39.1 332.6 16.5 196.6 0.2 8.4 3.3 2.9 10.0 4.2 6.1 6.1 4.6 0.7 4.1 4.0 2.7 29.8 1.5 7.8 2.8 8.6 7.2 26.5 29.4 23.0 30.1 21.3 33.7 34.4 25.7 30.4 21.2 28.1 27.5 164.0 19.2 7.5 46.4 25.1 20.3 19.7 81.6 18.8 5.0 71.3 44.7 18.9 10.0 54.7 23.9 0.0 6.0 12.4 105.8 5.9 25.8 1.5 19.6 35.2 106.1 25.2 20.2 19.2 56.7 35.0 51.8 20.9 51.8 18.4 35.4 97.1 36.0 3.3 0.0 14.8 13.0 57.0 9.6 14.3 4.2 43.5 17.3 7.2 31.9 25.5 50.4 8.2 13.6 22.5 100.4 106.5 55.3 29.4 34.9 45.7 7.5 24.2 4.4 39.5 72.7 47.5 1.3 5.9 8.5 16.1 10.5 17.9 80.6 21.6 40.8 ECE2 "KIAA0604, MGC2408" ENSG00000145194 "Endothelin converting enzyme 2" P0DPD6 3 184276011-184293031 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Methyltransferase, Multifunctional enzyme, Protease, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 57.8;pancreas: 25.2;pituitary gland: 19.8" "Cell type enhanced" "Detected in many" "Early spermatids: 79.5;Extravillous trophoblasts: 51.1;Inhibitory neurons: 63.8;Late spermatids: 119.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 9 "REH: 10.3" NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 14: REH - Unknown function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (2.70e-2)" "unprognostic (1.44e-2)" "unprognostic (1.91e-2)" "prognostic unfavorable (8.41e-5)" "unprognostic (1.37e-2)" "unprognostic (1.09e-1)" "prognostic unfavorable (5.80e-4)" "unprognostic (1.47e-2)" "unprognostic (3.69e-1)" "unprognostic (2.65e-3)" "unprognostic (1.70e-2)" "unprognostic (5.95e-2)" "unprognostic (1.63e-9)" "unprognostic (3.66e-2)" "unprognostic (6.16e-2)" "unprognostic (2.19e-1)" "unprognostic (1.25e-2)" 0.0 9.3 24.8 0.2 24.6 0.0 0.0 22.2 28.0 0.0 8.5 1.3 0.0 0.0 0.5 0.0 0.1 0.0 1.9 16.1 57.8 0.0 0.0 0.0 0.0 29.0 52.5 0.0 25.2 4.2 19.8 0.0 36.1 0.6 0.2 5.5 0.3 0.3 0.0 0.0 0.3 0.2 21.5 0.0 0.7 0.2 54.7 0.0 0.0 0.0 0.0 0.0 0.2 15.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.3 0.0 0.0 0.0 0.0 1.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 24.8 24.6 22.2 28.0 16.1 57.8 29.0 52.5 36.1 21.5 54.7 15.2 0.0 0.0 0.0 5.2 3.8 38.2 18.2 15.5 20.5 5.5 0.0 0.0 2.2 10.0 7.2 0.0 2.1 21.6 2.7 6.7 0.0 0.0 79.5 0.0 0.0 3.3 12.2 6.3 5.1 0.0 51.1 3.5 9.2 0.0 0.0 0.0 3.3 35.3 17.2 26.9 63.8 12.8 16.2 4.4 5.7 119.8 3.1 4.1 8.8 1.0 4.6 2.4 5.2 30.2 1.1 0.0 5.9 2.2 12.5 35.1 13.5 0.0 2.2 2.3 6.6 2.6 5.1 43.4 9.7 16.9 39.1 21.5 2.3 0.0 13.8 16.2 ECEL1 "DINE, XCE" ENSG00000171551 "Endothelin converting enzyme like 1" O95672 2 232479827-232487834 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "brain: 106.9;ovary: 99.7;pituitary gland: 27.6" "Cell type enhanced" "Detected in some" "Bipolar cells: 33.5;Muller glia cells: 100.3;Peritubular cells: 21.1" "Cancer enhanced" "Detected in many" "endometrial cancer: 12.9" "Region enhanced" "Detected in many" "hypothalamus: 106.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "AN3-CA: 44.1;HeLa: 21.8" "Region enhanced" "Detected in many" "hypothalamus: 70.7" "Low region specificity" "Detected in many" "HPA067560, HPA069756, HPA077424" Approved Supported Approved "Nucleoplasm,Nuclear membrane,Nucleoli" NA NA "Cluster 35: Non-specific - Unknown function" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 5: Muller glia cells - Visual perception" Nucleoplasm "Nuclear membrane, Nucleoli" "HPA067560: , HPA069756: , HPA077424: " "unprognostic (1.21e-2)" "unprognostic (1.06e-2)" "unprognostic (4.39e-1)" "unprognostic (4.62e-3)" "unprognostic (2.80e-1)" "unprognostic (9.96e-4)" "unprognostic (7.56e-3)" "unprognostic (1.22e-1)" "unprognostic (9.89e-3)" "unprognostic (8.49e-2)" "unprognostic (1.54e-1)" "unprognostic (2.89e-1)" "unprognostic (1.24e-5)" "unprognostic (3.09e-2)" "unprognostic (3.68e-1)" "unprognostic (7.84e-2)" "unprognostic (5.45e-2)" 1.8 10.0 5.2 1.0 5.5 0.0 1.7 1.2 31.6 1.0 3.4 0.8 0.1 2.2 0.0 0.4 3.5 0.5 0.2 0.5 106.9 4.1 2.5 0.4 0.3 20.9 11.3 99.7 0.7 1.2 27.6 0.3 17.1 0.4 0.0 13.4 0.6 1.5 3.0 0.6 0.4 1.4 2.4 4.5 0.9 1.9 44.2 0.2 1.4 0.0 0.4 0.4 1.1 4.5 0.0 0.1 0.1 44.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.6 0.4 0.0 0.2 0.0 0.6 0.0 0.0 0.0 4.0 0.0 21.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 3.1 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 5.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.2 5.5 1.2 31.6 0.5 106.9 20.9 11.3 17.1 2.4 44.2 4.5 0.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 33.5 0.5 0.3 1.1 0.0 0.0 0.0 2.1 0.0 0.1 0.0 0.0 0.2 1.1 1.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 4.5 0.0 1.0 0.0 0.5 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 2.2 1.5 0.1 0.0 0.0 0.0 100.3 0.0 0.0 0.0 0.1 0.0 21.1 0.0 0.0 0.0 0.1 0.0 3.7 0.0 1.0 2.3 0.5 1.6 0.0 0.0 0.0 0.1 0.6 0.0 0.1 EEF1AKMT4-ECE2 ENSG00000284917 "EEF1AKMT4-ECE2 readthrough" P0DPD8 3 184249695-184293031 "Enzymes, Predicted membrane proteins" "Hydrolase, Metalloprotease, Methyltransferase, Multifunctional enzyme, Protease, Transferase" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA062215 Uncertain Nucleoplasm,Cytosol NA NA "Nucleoplasm, Cytosol" "HPA062215: AB_2684714" 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ELANE "ELA2, HLE, HNE, NE" ENSG00000197561 "Elastase, neutrophil expressed" P08246 19 851014-856247 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 91 "bone marrow: 3894.9" "Cell type enhanced" "Detected in some" "Basal keratinocytes: 8.7;Fibroblasts: 16.2;Langerhans cells: 11.1;Leydig cells: 6.2;Melanocytes: 7.2;Suprabasal keratinocytes: 7.4" "Group enriched" "Detected in some" 7 "pancreatic cancer: 3.5;stomach cancer: 3.7" "Not detected" "Not detected" "Group enriched" "Detected in some" 9 "classical monocyte: 4.0;neutrophil: 12.1" "Group enriched" "Detected in many" 9 "granulocytes: 12.1;monocytes: 4.0" "Cell line enriched" "Detected in some" 91 "THP-1: 3105.0" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB015409, HPA066836, HPA073774" Enhanced "Secreted to blood" NA NA 370000 "Cluster 1: Neutrophils - Mixed function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 43: THP-1 - Innate immune response" "Cluster 50: Fibroblasts - ECM organization" "CAB015409: AB_831596, HPA066836: AB_2685733, HPA073774: " "unprognostic (3.46e-2)" "unprognostic (1.10e-1)" "unprognostic (1.42e-3)" "unprognostic (2.09e-2)" "unprognostic (1.80e-3)" "unprognostic (3.43e-2)" "unprognostic (3.92e-1)" "unprognostic (6.38e-3)" "unprognostic (5.80e-1)" "unprognostic (2.54e-2)" "unprognostic (4.06e-2)" "unprognostic (3.48e-2)" "unprognostic (1.19e-10)" "unprognostic (6.27e-3)" "unprognostic (4.00e-2)" "unprognostic (2.76e-2)" "unprognostic (4.75e-3)" 3.4 1.0 0.3 0.0 0.3 3894.9 3.4 0.1 0.7 0.5 0.2 2.0 0.4 1.0 0.0 1.1 1.4 0.1 4.0 0.3 0.2 0.7 3.3 19.4 0.6 0.1 0.2 0.5 0.5 0.0 1.2 0.8 0.1 2.9 0.0 0.0 2.4 0.1 1.5 5.4 1.8 0.1 0.1 42.6 1.4 0.4 0.2 6.3 3.1 0.0 0.0 2.1 1.0 0.2 2.0 0.1 0.0 0.0 1.0 1.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.4 0.0 0.0 1.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 3105.0 0.0 0.0 0.1 0.0 1.3 0.0 0.2 0.8 0.0 34.0 0.0 0.0 4.0 0.0 0.9 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.1 0.0 0.0 0.0 0.0 27.2 0.3 0.3 0.1 0.7 0.3 0.2 0.1 0.2 0.1 0.1 0.2 0.2 0.9 0.0 0.0 0.0 0.3 8.7 0.0 0.0 0.0 0.0 0.2 0.6 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.7 0.0 4.2 0.1 0.0 1.3 16.2 0.0 0.1 0.0 0.0 0.7 0.9 0.2 0.0 0.1 0.0 0.0 3.4 11.1 0.0 6.2 1.1 7.2 0.0 0.9 0.0 1.0 0.0 0.1 0.0 0.0 1.5 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.6 1.0 0.2 0.0 0.0 7.4 0.0 0.7 0.2 0.0 0.0 ENPEP "CD249, gp160" ENSG00000138792 "Glutamyl aminopeptidase" Q07075 4 110365733-110565285 "CD markers, Enzymes, Plasma proteins, Predicted membrane proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 163.6;kidney: 90.0" "Cell type enhanced" "Detected in many" "Proximal enterocytes: 663.2;Proximal tubular cells: 177.6;Sertoli cells: 157.8" "Cancer enriched" "Detected in many" 8 "renal cancer: 41.0" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 2.7;HEK 293: 7.5;MOLT-4: 1.8;SuSa: 5.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA005128 Enhanced NA NA 55000000 "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 45: Enterocytes - Digestion" "HPA005128: AB_1844795" "unprognostic (2.73e-3)" "unprognostic (2.84e-3)" "unprognostic (5.16e-3)" "unprognostic (3.48e-1)" "unprognostic (2.90e-1)" "unprognostic (8.74e-2)" "unprognostic (3.34e-2)" "unprognostic (1.03e-1)" "unprognostic (1.35e-2)" "unprognostic (1.22e-1)" "unprognostic (1.93e-1)" "unprognostic (9.47e-2)" "unprognostic (4.49e-3)" "unprognostic (3.43e-3)" "unprognostic (1.52e-2)" "unprognostic (8.46e-2)" "unprognostic (2.49e-3)" 11.6 2.2 0.4 1.5 0.5 0.1 4.8 0.4 2.5 1.6 1.8 1.2 36.6 12.9 4.1 1.7 2.3 4.4 4.3 0.6 0.5 90.0 29.0 4.6 0.8 0.9 0.8 1.2 1.3 45.2 1.2 15.5 0.7 1.8 0.8 0.0 1.1 1.2 2.3 0.7 163.6 10.6 0.5 9.2 1.2 0.5 0.4 4.4 5.0 8.9 0.3 2.6 1.6 0.8 0.0 0.2 0.0 0.0 0.1 0.1 2.7 0.4 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 7.5 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.0 1.8 0.3 0.3 0.1 0.0 0.1 0.0 0.3 0.0 0.3 0.1 0.1 0.0 1.3 0.0 5.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.7 1.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.5 0.4 2.5 0.6 0.5 0.9 0.8 0.7 0.5 0.4 0.8 10.7 0.0 2.0 1.6 1.1 1.7 0.1 0.0 0.0 0.0 0.2 0.1 3.9 0.0 0.3 11.0 0.0 37.0 0.0 1.5 17.6 0.0 0.5 3.1 40.7 2.2 1.8 0.0 7.3 0.0 3.5 15.4 0.0 2.3 0.0 0.0 1.4 31.4 2.7 0.0 2.9 28.4 2.0 1.0 1.9 0.2 0.6 1.1 0.0 1.0 0.0 0.0 1.0 0.0 0.8 0.0 31.6 0.4 0.1 0.2 663.2 177.6 1.7 0.0 157.8 0.8 54.1 0.0 0.2 0.1 1.0 58.6 1.9 0.5 42.1 0.1 EPHX1 EPHX ENSG00000143819 "Epoxide hydrolase 1" P07099 1 225810124-225845563 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Aromatic hydrocarbons catabolism, Detoxification" Hydrolase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 1178.6;liver: 1705.1" "Cell type enhanced" "Detected in many" "Granulosa cells: 349.9;Hepatocytes: 757.6;Theca cells: 1042.6" "Cancer enriched" "Detected in all" 6 "liver cancer: 1047.0" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "classical monocyte: 2.6" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in all" "ASC diff: 1161.8;SiHa: 413.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020593, HPA048847" Enhanced NA NA 160000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 15: Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 2: Hepatocytes - Metabolism" "HPA020593: AB_10601373, HPA048847: AB_2680538" "unprognostic (2.85e-2)" "unprognostic (2.52e-2)" "unprognostic (2.00e-2)" "unprognostic (2.53e-3)" "unprognostic (2.50e-1)" "unprognostic (6.60e-2)" "unprognostic (3.92e-2)" "prognostic favorable (7.02e-5)" "unprognostic (1.02e-1)" "unprognostic (2.53e-2)" "unprognostic (1.01e-1)" "prognostic favorable (1.32e-4)" "unprognostic (8.10e-2)" "unprognostic (1.80e-1)" "unprognostic (1.65e-1)" "unprognostic (5.15e-2)" "unprognostic (1.88e-2)" 245.8 1178.6 233.5 23.6 252.5 22.7 163.7 239.0 249.3 188.3 345.8 82.0 102.2 108.1 97.6 159.6 153.8 96.5 94.0 221.3 233.7 110.7 1705.1 146.8 39.1 225.3 234.9 329.1 536.1 147.7 105.8 32.9 223.6 113.2 52.5 30.7 143.6 128.1 142.5 71.5 52.8 109.6 210.1 55.7 99.9 74.3 258.4 25.9 171.1 95.6 33.4 135.4 140.4 227.2 32.1 202.3 12.3 108.5 1161.8 120.2 24.3 29.7 49.2 28.1 35.1 38.8 293.6 1.3 128.7 147.3 30.6 38.1 32.7 16.8 12.1 7.8 46.5 21.8 83.5 282.7 129.8 12.9 15.1 109.2 40.0 74.6 6.3 116.5 22.1 13.4 14.5 27.3 50.4 30.3 13.5 31.0 61.6 178.1 79.4 27.8 15.2 92.9 91.1 132.5 98.3 13.0 413.0 192.1 51.3 32.1 131.7 43.5 46.8 41.9 35.4 54.5 59.0 9.1 38.9 4.1 63.5 14.2 59.5 0.0 2.6 0.1 0.2 0.7 0.4 0.1 0.3 0.2 0.6 0.2 0.5 0.3 0.2 0.7 0.3 0.9 0.3 0.8 233.5 252.5 239.0 249.3 221.3 233.7 225.3 234.9 223.6 210.1 258.4 227.2 196.9 0.0 14.0 41.1 5.7 19.6 121.8 244.2 74.0 8.8 29.7 27.4 1.2 102.9 255.5 51.5 29.2 46.6 3.4 34.5 17.6 95.3 10.2 142.9 32.2 82.7 10.8 7.0 3.1 73.0 7.6 175.6 30.5 93.4 5.7 349.9 88.2 757.6 149.1 1.7 5.0 17.5 103.7 30.9 28.7 28.4 311.3 25.8 42.7 23.4 9.6 99.2 0.0 7.1 19.4 45.5 27.2 159.1 9.5 40.4 63.4 128.9 174.3 10.1 223.5 29.3 146.9 4.4 5.1 129.0 17.6 22.8 4.7 1042.6 31.5 108.5 ERAP1 "A-LAP, ARTS-1, ERAAP1, KIAA0525, PILS-AP" ENSG00000164307 "Endoplasmic reticulum aminopeptidase 1" Q9NZ08 5 96760810-96808100 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Adaptive immunity, Immunity" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 72.8;Inhibitory neurons: 79.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025095, HPA042317" Approved Approved "Nucleoplasm,Plasma membrane,Cytosol" "Secreted to blood" NA NA 30000000 "Cluster 34: Basophils - Unknown function" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Cytosol" "Plasma membrane" "CAB025095: , HPA042317: AB_2677946" "unprognostic (2.33e-3)" "unprognostic (3.45e-1)" "unprognostic (1.84e-3)" "unprognostic (1.34e-1)" "unprognostic (1.86e-1)" "unprognostic (4.38e-1)" "unprognostic (1.88e-3)" "unprognostic (5.37e-2)" "unprognostic (1.45e-1)" "unprognostic (7.94e-2)" "unprognostic (4.52e-2)" "unprognostic (3.23e-1)" "unprognostic (7.09e-2)" "unprognostic (1.36e-1)" "unprognostic (3.93e-2)" "unprognostic (1.19e-1)" "unprognostic (5.14e-2)" 51.5 15.8 3.7 37.0 4.3 27.9 25.5 3.1 5.6 21.8 2.3 37.9 63.4 22.0 14.4 13.2 25.5 23.7 17.1 3.4 5.2 16.4 32.9 31.2 38.2 8.4 5.7 20.7 13.7 19.1 8.2 47.0 7.0 18.6 43.7 12.4 19.3 22.0 20.9 36.5 55.1 21.7 5.0 30.8 33.7 9.1 6.6 63.7 17.5 19.6 36.8 27.3 11.7 6.8 25.9 14.1 21.3 20.0 114.7 111.5 61.4 18.3 59.6 44.0 76.2 17.6 91.1 75.3 37.6 36.0 61.8 25.7 17.8 38.1 27.3 139.8 7.5 24.7 10.0 13.9 130.9 12.0 44.1 46.8 16.2 50.6 15.5 64.3 61.1 48.8 12.9 74.7 26.7 11.6 113.2 12.4 10.6 3.1 10.4 82.4 28.8 38.4 32.8 39.0 7.8 5.5 29.6 19.8 28.6 14.6 17.1 57.0 48.8 37.4 12.6 6.2 31.1 26.9 53.9 57.8 40.2 40.2 22.5 28.8 15.2 18.0 22.6 12.3 20.2 14.8 19.2 19.1 10.5 18.3 22.3 18.1 15.8 23.1 20.6 16.7 13.9 13.7 3.7 4.3 3.1 5.6 3.4 5.2 8.4 5.7 7.0 5.0 6.6 6.8 11.1 9.6 16.3 34.0 15.3 25.0 14.2 19.2 8.6 13.6 6.6 3.9 10.6 10.0 16.9 9.2 2.1 9.6 21.1 24.4 0.0 12.4 27.0 12.7 15.0 16.3 10.3 14.1 72.8 15.5 11.9 18.4 16.3 19.8 15.2 13.9 16.8 28.0 17.6 3.3 79.3 23.9 4.1 29.9 16.1 7.3 9.9 22.9 7.2 24.4 32.5 9.0 20.6 32.6 70.1 12.3 14.1 16.1 32.3 13.5 47.3 6.9 23.1 7.6 0.0 10.3 22.6 1.4 1.8 9.8 11.1 9.2 21.8 5.7 27.3 14.9 ERAP2 "L-RAP, LRAP" ENSG00000164308 "Endoplasmic reticulum aminopeptidase 2" Q6P179 5 96875986-96919703 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Adaptive immunity, Immunity" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 49.9" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "CAPAN-2: 176.1;GAMG: 105.0;hTEC/SVTERT24-B: 83.2;MOLT-4: 98.8;TIME: 188.7" "Low region specificity" "Detected in all" "CAB025618, HPA034498, HPA064360" Enhanced Approved "Golgi apparatus" "Secreted to blood" NA NA 11000000 "Cluster 15: NK-cells - Transcription" "Cluster 3: T-cells - Adaptive immune response" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 63: NK-cells & T-cells - Immune response" "Golgi apparatus" "CAB025618: , HPA034498: AB_2674191, HPA064360: " "unprognostic (4.62e-2)" "unprognostic (1.60e-1)" "unprognostic (4.98e-2)" "unprognostic (1.56e-1)" "unprognostic (3.14e-1)" "unprognostic (8.71e-2)" "unprognostic (2.60e-2)" "unprognostic (1.17e-2)" "unprognostic (5.03e-2)" "unprognostic (1.40e-1)" "prognostic unfavorable (1.20e-4)" "unprognostic (1.01e-1)" "unprognostic (9.54e-3)" "unprognostic (6.59e-2)" "unprognostic (8.48e-2)" "unprognostic (4.65e-2)" "unprognostic (3.05e-1)" 7.8 7.1 3.0 31.5 3.0 7.5 11.9 2.3 4.3 12.2 3.0 16.2 32.6 8.4 17.5 10.5 7.0 11.0 7.5 2.9 2.5 11.3 14.5 18.1 46.4 4.3 3.3 8.5 2.9 3.7 3.6 11.0 3.5 10.3 6.2 2.3 6.6 7.0 8.9 10.1 21.5 3.4 2.7 36.7 19.0 1.7 3.8 49.9 5.6 9.9 29.7 14.7 6.8 3.5 2.1 2.4 1.7 0.9 1.9 3.8 0.6 8.1 13.8 7.3 12.3 7.9 176.1 12.2 35.1 11.5 105.0 2.9 0.9 65.4 5.8 4.3 7.9 0.6 3.0 8.5 2.7 43.2 19.2 25.3 12.8 83.2 0.6 1.2 4.9 27.4 0.2 25.8 20.8 1.4 98.8 22.5 0.2 0.0 3.7 45.7 16.2 29.3 55.2 15.4 3.5 0.2 1.1 0.9 16.5 0.4 6.5 1.7 188.7 3.9 1.1 10.0 24.6 26.2 23.2 4.2 50.8 5.8 0.9 23.0 12.1 15.4 24.8 27.5 31.3 28.5 34.6 30.6 19.8 17.7 37.4 28.9 4.2 45.4 28.5 6.9 34.6 27.6 3.0 3.0 2.3 4.3 2.9 2.5 4.3 3.3 3.5 2.7 3.8 3.5 46.7 32.1 20.0 11.8 62.6 5.7 11.2 24.4 12.0 1.5 3.1 5.8 4.4 8.6 15.9 44.1 0.0 11.5 35.6 48.1 0.0 5.3 0.3 7.0 10.6 34.1 1.8 15.8 2.5 25.5 17.0 23.4 17.3 7.4 7.0 33.4 31.4 16.3 12.3 0.0 2.1 23.3 8.2 29.4 14.2 0.7 10.5 33.0 7.2 21.5 19.4 6.5 20.6 7.1 4.9 22.1 27.6 7.9 56.0 4.3 52.4 6.2 15.7 2.8 0.0 12.2 12.2 0.9 0.8 10.0 3.0 6.7 54.2 9.3 34.2 10.5 ERMP1 "FLJ23309, FXNA, KIAA1815" ENSG00000099219 "Endoplasmic reticulum metallopeptidase 1" Q7Z2K6 9 5765076-5833117 "Enzymes, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 50.1" "Cell type enhanced" "Detected in many" "Collecting duct cells: 73.5;Granulosa cells: 53.4;Oligodendrocytes: 88.8;Urothelial cells: 66.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "NK-cell: 1.6" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "RPTEC TERT1: 76.8;RT4: 154.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA055582 Approved NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 15: RT4 - Unknown function" "Cluster 52: Non-specific - Transcription" "HPA055582: " "unprognostic (1.93e-2)" "unprognostic (3.40e-1)" "unprognostic (2.76e-2)" "unprognostic (5.93e-2)" "unprognostic (2.97e-1)" "unprognostic (8.59e-2)" "unprognostic (4.30e-3)" "unprognostic (2.81e-1)" "unprognostic (5.46e-2)" "unprognostic (4.83e-3)" "unprognostic (3.14e-2)" "unprognostic (2.88e-2)" "prognostic favorable (5.83e-10)" "unprognostic (1.41e-1)" "unprognostic (4.00e-1)" "unprognostic (5.77e-2)" "unprognostic (1.36e-1)" 3.9 7.9 4.2 3.7 10.4 2.0 6.3 10.9 3.7 10.8 14.4 11.3 4.4 5.6 2.6 14.9 6.4 11.3 10.0 2.9 6.1 24.9 4.6 6.3 3.5 10.1 10.3 4.5 3.9 50.1 1.5 7.8 8.8 6.0 11.4 2.2 19.1 4.1 7.6 9.3 6.5 3.8 6.5 3.1 13.3 4.7 8.9 4.6 26.6 9.9 6.4 17.1 4.8 13.1 45.1 43.1 1.8 5.2 22.6 20.7 22.6 5.1 11.1 2.3 1.9 10.4 27.2 10.7 19.2 8.4 25.9 32.2 9.6 29.4 3.3 55.6 7.6 56.2 20.0 20.4 4.8 16.0 21.3 10.5 12.9 2.1 13.3 28.6 30.1 4.6 6.9 9.9 2.8 20.7 0.6 6.2 6.6 28.0 8.4 1.7 5.3 14.1 76.8 154.6 9.9 3.3 7.1 52.2 8.1 24.5 33.7 20.5 18.0 1.5 5.0 3.4 16.1 8.9 13.6 5.5 6.7 13.0 4.1 0.2 0.1 0.3 0.4 0.1 0.6 0.0 0.2 0.1 0.0 0.0 0.1 0.1 0.0 1.6 0.0 0.1 0.1 0.1 4.2 10.4 10.9 3.7 2.9 6.1 10.1 10.3 8.8 6.5 8.9 13.1 3.4 6.4 1.1 24.8 2.2 2.9 18.3 13.3 2.8 4.0 11.1 5.8 13.7 12.8 22.8 73.5 10.4 6.8 5.2 32.1 0.0 4.6 22.3 11.4 10.9 6.3 11.4 6.3 21.0 3.0 7.1 4.6 13.7 13.8 8.9 53.4 2.9 6.1 5.7 3.3 32.8 8.9 10.2 1.6 2.2 41.8 3.1 4.5 1.8 24.4 2.1 3.0 8.2 22.1 88.8 3.5 22.5 4.9 4.1 7.0 9.2 3.3 16.6 2.9 6.6 5.8 4.3 8.8 4.6 17.5 4.5 4.1 5.9 39.8 15.7 66.9 F10 ENSG00000126218 "Coagulation factor X" P00742 13 113122799-113149529 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Blood coagulation, Hemostasis" "Hydrolase, Protease, Serine protease" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 160.0" "Cell type enhanced" "Detected in many" "Fibroblasts: 113.6;Hepatocytes: 195.1;Leydig cells: 215.9;Peritubular cells: 236.2" "Cancer enriched" "Detected in many" 11 "liver cancer: 95.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ: 14.4;BJ hTERT+: 11.5;CACO-2: 12.7;fHDF/TERT166: 13.1;Hep G2: 59.6;HHSteC: 11.5;SH-SY5Y: 27.9" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Secreted to blood" NA NA 13000000000 "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 50: Fibroblasts - ECM organization" "unprognostic (4.18e-2)" "unprognostic (1.07e-1)" "unprognostic (7.62e-2)" "unprognostic (9.88e-2)" "unprognostic (9.44e-2)" "unprognostic (1.15e-2)" "unprognostic (4.90e-2)" "unprognostic (1.02e-2)" "unprognostic (2.54e-1)" "unprognostic (1.24e-1)" "prognostic favorable (1.82e-5)" "unprognostic (6.39e-2)" "prognostic unfavorable (5.14e-5)" "unprognostic (6.60e-2)" "unprognostic (1.21e-1)" "unprognostic (3.87e-2)" "unprognostic (2.23e-3)" 21.3 8.5 1.1 1.5 1.2 0.0 11.7 2.5 2.0 53.8 1.4 5.6 10.9 13.2 16.4 8.9 23.9 10.9 40.7 1.1 1.8 4.1 160.0 14.4 3.2 2.6 1.5 27.9 7.1 0.2 4.5 4.4 2.5 12.8 2.0 0.9 5.1 7.1 6.8 20.7 11.9 2.7 1.3 3.2 8.6 10.1 1.4 1.4 8.3 6.6 1.3 11.9 25.8 1.1 0.1 0.0 2.5 0.4 8.0 8.1 0.1 14.4 11.5 0.8 0.3 12.7 0.1 0.1 0.5 13.1 1.4 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.2 59.6 11.5 0.0 0.3 8.1 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.2 1.5 0.1 0.0 0.3 0.0 1.3 0.2 0.3 0.1 0.0 0.0 0.2 1.0 27.9 0.1 0.5 0.1 0.6 0.6 0.1 0.0 0.0 0.8 0.2 0.0 0.2 0.0 0.1 0.1 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 1.2 2.5 2.0 1.1 1.8 2.6 1.5 2.5 1.3 1.4 1.1 7.0 0.0 0.0 1.3 0.6 15.7 0.1 0.0 0.0 1.1 0.4 0.3 9.1 4.3 0.0 1.8 0.0 0.6 0.0 0.1 0.0 0.1 2.9 1.9 45.9 3.8 17.9 2.7 1.3 0.0 0.4 113.6 6.1 1.0 1.3 2.2 7.9 195.1 1.4 6.7 1.4 5.0 0.0 4.8 25.0 9.6 215.9 1.3 19.6 5.6 0.6 4.5 0.0 0.5 0.1 0.3 6.5 236.2 0.0 0.3 28.3 6.4 0.0 1.2 52.6 14.5 40.9 2.3 1.2 0.5 15.3 1.1 1.9 2.4 2.2 0.4 F11 FXI ENSG00000088926 "Coagulation factor XI" P03951 4 186266189-186289681 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Blood coagulation, Hemostasis" "Heparin-binding, Hydrolase, Protease, Serine protease" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 4 "liver: 243.2" "Group enriched" "Detected in some" 4 "Alveolar cells type 2: 27.6;Hepatocytes: 75.7" "Cancer enriched" "Detected in some" 13 "liver cancer: 16.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 9 "Hep G2: 6.3" "Not detected" "Not detected" "Low region specificity" "Detected in some" HPA039808 Approved Vesicles "Secreted to blood" NA NA 4400000000 "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 15: Hepatocytes - Hemostasis" Vesicles "HPA039808: AB_2676693" "unprognostic (1.28e-1)" "unprognostic (3.15e-1)" "prognostic favorable (3.29e-5)" "unprognostic (1.88e-1)" "unprognostic (2.08e-1)" "unprognostic (2.11e-1)" "unprognostic (1.85e-3)" "unprognostic (2.91e-2)" "unprognostic (7.65e-2)" 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.5 0.2 0.0 0.2 17.1 0.2 0.1 0.0 0.0 13.1 0.0 0.2 0.0 27.6 243.2 8.4 0.0 0.0 0.3 0.3 58.9 0.0 0.2 0.0 0.1 0.0 0.1 0.7 0.0 0.2 0.7 0.0 8.7 0.0 0.0 0.1 0.8 0.1 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 6.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.5 0.2 0.0 0.0 0.3 0.1 0.0 0.3 0.0 0.0 0.0 27.6 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 4.3 2.5 1.8 0.0 0.0 0.2 0.3 11.7 2.3 0.0 0.0 0.0 0.1 0.0 5.3 0.6 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 75.7 0.0 0.0 0.6 0.0 0.0 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.3 2.1 0.0 0.0 0.0 0.0 1.1 5.5 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 F12 ENSG00000131187 "Coagulation factor XII" P00748 5 177402141-177409564 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Blood coagulation, Fibrinolysis, Hemostasis" "Hydrolase, Protease, Serine protease" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 226 "liver: 604.6" "Cell type enriched" "Detected in many" 8 "Hepatocytes: 523.0" "Cancer enriched" "Detected in many" 21 "liver cancer: 171.0" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 5 "classical monocyte: 1.2;eosinophil: 3.6" "Group enriched" "Detected in many" 5 "granulocytes: 3.6;monocytes: 1.2" "Cell line enhanced" "Detected in some" "HDLM-2: 7.1;MCF7: 9.0;PC-3: 6.4;SH-SY5Y: 4.3;U-937: 4.6" "Low region specificity" "Detected in single" "Low region specificity" "Detected in many" HPA003825 Approved "Secreted to blood" NA NA 1040000 7000000000 "Cluster 52: Eosinophils - Transcription" "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 2: Hepatocytes - Metabolism" "HPA003825: AB_1078790" "unprognostic (9.75e-2)" "unprognostic (1.71e-1)" "unprognostic (2.93e-1)" "unprognostic (4.47e-2)" "unprognostic (1.01e-1)" "unprognostic (2.32e-1)" "prognostic favorable (4.63e-5)" "unprognostic (6.97e-2)" "unprognostic (1.26e-2)" "unprognostic (3.96e-2)" "unprognostic (4.41e-1)" "unprognostic (6.54e-2)" "prognostic unfavorable (7.09e-4)" "unprognostic (4.11e-2)" "unprognostic (3.69e-1)" "unprognostic (3.40e-6)" "unprognostic (6.48e-2)" 0.4 0.1 1.4 0.1 1.2 2.6 0.3 0.1 1.3 0.4 0.1 0.5 0.5 0.2 0.0 1.9 0.3 0.1 0.4 1.5 0.8 0.8 604.6 0.6 0.0 0.8 0.6 0.0 0.6 0.1 0.6 0.1 0.9 0.3 0.1 0.0 0.4 0.0 0.0 0.9 0.5 0.0 0.4 1.0 0.1 1.2 0.8 0.0 0.2 0.0 0.1 0.2 0.8 0.8 0.7 1.6 0.0 0.4 0.0 0.0 0.2 0.0 0.0 0.0 0.0 1.8 1.0 0.0 0.3 0.0 0.2 1.1 0.5 0.3 0.0 7.1 1.4 1.1 0.3 0.7 0.2 0.6 2.4 0.2 1.0 0.0 0.3 0.1 0.2 1.6 0.3 2.5 0.0 9.0 0.1 2.1 0.0 2.1 6.4 0.5 0.2 1.5 0.9 0.0 2.0 4.3 0.2 0.7 0.6 0.0 0.3 0.0 0.0 0.1 0.8 0.0 0.2 0.4 0.0 0.0 0.0 4.6 0.5 0.0 1.2 3.6 0.1 0.0 0.1 0.2 0.1 0.1 0.0 0.0 0.0 0.0 0.4 0.3 0.5 0.5 0.0 0.5 1.4 1.2 0.1 1.3 1.5 0.8 0.8 0.6 0.9 0.4 0.8 0.8 0.5 0.0 0.0 0.3 5.3 33.1 7.7 15.3 35.9 0.6 12.7 17.5 1.0 17.2 3.9 1.8 4.2 0.0 4.0 27.6 0.0 6.5 23.3 2.2 0.9 2.2 10.3 19.6 2.6 4.2 0.4 1.1 3.6 1.7 0.0 0.2 16.8 523.0 0.5 0.0 0.8 12.3 8.2 16.7 6.1 42.1 0.6 1.0 8.8 0.0 1.2 0.7 2.1 1.5 0.6 11.1 22.0 0.0 8.5 7.2 60.7 16.1 3.6 0.9 0.0 0.5 1.1 12.0 23.6 57.5 54.3 0.1 4.0 0.1 34.8 7.6 F2 ENSG00000180210 "Coagulation factor II, thrombin" P00734 11 46719196-46739506 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Acute phase, Blood coagulation, Hemostasis" "Hydrolase, Protease, Serine protease" "Cancer-related genes, Disease variant, FDA approved drug targets, Thrombophilia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 1518 "liver: 1217.3" "Cell type enriched" "Detected in some" 26 "Hepatocytes: 991.0" "Cancer enriched" "Detected in some" 110 "liver cancer: 508.2" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 22 "Hep G2: 281.0" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB016780, HPA051476, HPA054698" Enhanced "Secreted to blood" NA NA 108000000000 41000000000 "Cluster 62: Liver - Hemostasis" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 15: Hepatocytes - Hemostasis" "CAB016780: , HPA051476: AB_2681498, HPA054698: AB_2682578" "unprognostic (1.98e-1)" "unprognostic (2.52e-1)" "unprognostic (2.64e-2)" "unprognostic (1.85e-1)" "unprognostic (2.29e-1)" "unprognostic (2.81e-1)" "unprognostic (2.23e-2)" "unprognostic (3.94e-2)" "unprognostic (5.79e-2)" "unprognostic (8.29e-2)" "unprognostic (4.46e-2)" "prognostic unfavorable (6.75e-12)" "unprognostic (5.65e-3)" "unprognostic (5.80e-2)" "unprognostic (1.54e-3)" 0.1 0.0 0.2 0.0 0.2 0.0 0.0 0.8 0.3 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.2 0.2 0.2 1217.3 0.0 0.0 0.2 0.2 0.1 0.0 0.0 0.1 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.3 0.5 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 12.9 0.0 0.2 2.2 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.5 0.2 281.0 0.0 1.5 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 1.0 0.0 0.0 0.2 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.2 0.0 0.5 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.8 0.3 0.2 0.2 0.2 0.2 0.2 0.1 0.2 0.3 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 20.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.2 1.2 0.0 37.5 0.2 0.0 0.0 0.0 0.0 0.9 0.0 0.3 21.8 991.0 0.0 0.0 0.2 0.2 0.0 26.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.3 2.0 0.0 0.0 0.1 F7 ENSG00000057593 "Coagulation factor VII" P08709 13 113105788-113120685 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Blood coagulation, Hemostasis" "Hydrolase, Protease, Serine protease" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 102 "liver: 160.2" "Cell type enriched" "Detected in some" 18 "Hepatocytes: 149.3" "Cancer enriched" "Detected in some" 17 "liver cancer: 41.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 9 "CACO-2: 11.5;Hep G2: 7.3" "Not detected" "Not detected" "Not detected" "Not detected" HPA004826 Approved Mitochondria "Secreted to blood" NA NA 351000000 1300000000 "Cluster 62: Liver - Hemostasis" "Cluster 39: CACO-2 - Unknown function" "Cluster 2: Hepatocytes - Metabolism" Mitochondria "HPA004826: AB_10602805" "unprognostic (2.06e-1)" "unprognostic (2.55e-1)" "unprognostic (1.03e-1)" "unprognostic (1.34e-1)" "unprognostic (3.27e-1)" "unprognostic (1.91e-1)" "unprognostic (1.50e-3)" "unprognostic (3.81e-1)" "unprognostic (4.36e-3)" "unprognostic (1.16e-1)" "unprognostic (4.19e-3)" "unprognostic (1.15e-1)" "unprognostic (1.35e-3)" "unprognostic (3.36e-3)" "unprognostic (1.09e-1)" "unprognostic (2.86e-1)" "unprognostic (1.47e-1)" 0.2 0.0 0.4 0.1 0.3 0.0 0.2 0.5 0.7 1.1 0.2 0.1 0.5 0.1 0.6 0.1 0.5 0.0 0.2 0.3 0.7 0.4 160.2 0.1 0.0 0.3 0.5 0.4 0.1 0.2 0.4 0.1 0.3 0.4 0.0 0.2 0.3 0.0 0.0 0.4 0.8 0.0 0.2 0.1 0.1 1.5 0.6 0.0 0.1 0.0 0.0 0.1 0.5 0.3 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 11.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 7.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.3 0.5 0.7 0.3 0.7 0.3 0.5 0.3 0.2 0.6 0.3 0.9 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.6 0.6 0.3 0.5 1.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.3 0.4 0.0 8.0 0.3 0.2 0.0 0.4 0.0 0.2 0.0 0.3 2.2 149.3 0.1 0.0 0.5 0.4 0.0 2.8 0.7 0.2 0.9 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 1.9 0.0 0.0 1.1 0.3 0.0 0.2 0.0 0.5 0.1 3.2 4.1 0.0 0.1 0.1 0.2 0.1 0.3 0.0 F9 FIX ENSG00000101981 "Coagulation factor IX" P00740 X 139530739-139563459 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Blood coagulation, Hemostasis" "Hydrolase, Protease, Serine protease" "Disease variant, FDA approved drug targets, Hemophilia, Thrombophilia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 2467 "liver: 704.9" "Cell type enriched" "Detected in some" 32 "Hepatocytes: 609.1" "Cancer enriched" "Detected in single" 1354 "liver cancer: 67.6" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted to blood" NA NA 8200000000 "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 15: Hepatocytes - Hemostasis" "prognostic favorable (6.69e-4)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 704.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 12.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 18.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.6 609.1 0.0 0.0 0.1 0.0 0.0 16.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 FAP DPPIV ENSG00000078098 "Fibroblast activation protein alpha" Q12884 2 162170684-162245151 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Angiogenesis, Apoptosis, Cell adhesion" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "endometrium 1: 31.4;smooth muscle: 26.4" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 67.6;Fibroblasts: 43.4;Microglial cells: 17.8;Muller glia cells: 57.5;Smooth muscle cells: 25.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 192.2;ASC TERT1: 202.3;BJ hTERT+: 167.8;hTERT-RPE1: 209.1;U-138 MG: 167.3" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 5 "cerebral cortex: 3.1;hippocampal formation: 2.4" HPA059739 Uncertain "Secreted to blood" NA NA 108000000 56000000 "Cluster 46: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "HPA059739: AB_2684117" "unprognostic (7.48e-3)" "unprognostic (7.87e-3)" "unprognostic (4.10e-2)" "unprognostic (5.04e-2)" "unprognostic (1.49e-2)" "prognostic unfavorable (4.82e-4)" "unprognostic (2.01e-2)" "unprognostic (1.05e-2)" "unprognostic (3.30e-2)" "unprognostic (4.89e-2)" "unprognostic (4.59e-2)" "unprognostic (3.52e-1)" "unprognostic (7.32e-11)" "unprognostic (1.72e-3)" "unprognostic (9.84e-3)" "unprognostic (7.97e-2)" "unprognostic (4.49e-3)" 5.8 0.2 0.9 5.2 0.9 0.0 10.1 0.4 0.9 15.2 0.0 3.5 0.5 31.4 8.5 3.6 4.8 22.3 4.9 0.3 1.4 0.7 0.2 4.0 1.5 0.6 0.5 3.0 2.5 0.7 0.5 23.1 0.6 1.9 2.5 6.4 4.7 5.8 4.4 2.8 0.9 26.4 0.2 0.4 1.0 1.5 1.0 0.5 2.8 7.5 1.5 15.5 3.6 0.7 0.0 0.0 0.0 0.0 192.2 202.3 0.4 82.8 167.8 16.6 25.4 0.0 0.0 0.0 0.6 31.3 0.0 0.1 0.0 5.1 8.0 0.0 0.0 0.1 1.2 0.0 19.5 0.0 0.0 66.2 1.2 28.1 5.2 209.1 0.1 0.0 0.0 0.0 53.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 8.5 0.0 9.0 0.2 0.1 0.0 84.3 167.3 3.1 41.4 0.4 0.0 0.1 0.0 37.5 0.1 45.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.9 0.4 0.9 0.3 1.4 0.6 0.5 0.6 0.2 1.0 0.7 3.9 0.0 0.0 5.5 0.2 4.5 0.1 7.0 0.0 1.8 0.3 0.5 0.4 0.0 0.3 0.0 0.0 0.9 0.1 0.0 0.0 0.2 6.7 3.4 67.6 6.4 4.9 0.0 13.3 0.2 1.9 43.4 0.0 6.2 0.0 0.0 1.4 0.0 0.9 1.7 0.3 1.4 0.0 0.0 2.6 4.1 8.4 0.8 3.6 17.8 0.0 57.5 0.0 0.5 4.2 1.0 0.0 0.0 0.3 0.0 0.0 1.2 0.2 2.0 0.0 4.7 25.2 2.3 0.4 0.4 4.3 1.8 0.8 1.3 0.2 0.0 FOLH1 "FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA" ENSG00000086205 "Folate hydrolase 1" Q04609 11 49145092-49208638 "Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Carboxypeptidase, Dipeptidase, Hydrolase, Metalloprotease, Multifunctional enzyme, Protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 266.4;prostate: 76.0" "Cell type enriched" "Detected in some" 8 "Oligodendrocytes: 367.6" "Cancer enriched" "Detected in many" 27 "prostate cancer: 142.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HAP1: 2.3;RPMI-8226: 1.7;SK-BR-3: 1.8;TIME: 1.3;WM-115: 2.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001451, HPA010593" Enhanced NA NA "Cluster 56: Intestine - Transmembrane transport" "Cluster 17: WM-115 - Nervous system development" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "CAB001451: AB_563979, HPA010593: AB_1079685" "unprognostic (1.33e-1)" "unprognostic (1.19e-1)" "unprognostic (1.24e-1)" "prognostic favorable (5.24e-5)" "unprognostic (2.55e-1)" "unprognostic (8.31e-2)" "prognostic favorable (4.25e-4)" "unprognostic (1.32e-1)" "unprognostic (2.09e-2)" "unprognostic (2.67e-3)" "unprognostic (2.13e-2)" "unprognostic (2.72e-1)" "prognostic unfavorable (1.30e-6)" "unprognostic (4.81e-2)" "unprognostic (7.27e-2)" "unprognostic (4.74e-3)" "unprognostic (4.04e-1)" 1.8 1.1 17.3 0.9 37.3 0.7 4.8 27.1 27.7 1.9 7.9 0.7 266.4 1.7 0.9 1.5 3.5 10.2 0.5 18.3 22.4 13.5 35.5 1.3 0.9 32.7 28.4 1.0 0.3 0.2 0.0 0.3 31.5 76.0 0.5 4.0 52.8 0.6 0.2 1.7 82.9 1.0 24.1 2.4 1.1 0.8 31.1 0.1 1.0 0.2 0.6 1.4 0.3 59.3 0.1 0.0 0.0 0.0 0.0 0.0 1.1 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.3 0.0 0.1 0.1 2.3 0.2 0.0 0.5 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.5 0.4 0.0 0.0 0.1 0.1 1.7 0.0 0.0 0.2 0.7 0.0 1.8 0.3 0.2 0.3 0.0 1.3 0.1 0.9 0.2 0.1 0.0 0.2 0.0 0.0 0.4 2.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 17.3 37.3 27.1 27.7 18.3 22.4 32.7 28.4 31.5 24.1 31.1 59.3 0.5 0.0 0.6 0.0 0.0 0.3 0.7 0.1 0.6 0.0 8.2 7.0 0.3 0.0 1.9 0.0 0.0 0.0 0.5 0.0 7.9 0.0 5.2 2.1 0.5 5.0 0.0 0.0 0.5 0.0 0.0 2.2 0.0 2.8 0.0 0.0 2.9 25.9 0.1 0.0 1.0 1.1 0.0 0.3 0.0 1.4 1.5 0.2 3.6 1.0 0.0 17.4 0.0 0.0 367.6 0.0 1.2 0.4 0.0 43.0 0.8 32.4 0.1 0.6 0.0 0.0 0.4 1.1 1.5 1.5 0.9 0.0 0.2 0.5 0.2 0.6 FURIN "FUR, PACE, PCSK3, SPC1" ENSG00000140564 "Furin, paired basic amino acid cleaving enzyme" P09958 15 90868588-90883564 "Enzymes, Plasma proteins, Predicted membrane proteins" "Host-virus interaction" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 305.6;salivary gland: 220.5" "Cell type enhanced" "Detected in many" "Exocrine glandular cells: 117.5;Hepatocytes: 131.8;Pancreatic endocrine cells: 108.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009499, HPA067869" Enhanced Supported "Nucleoplasm,Golgi apparatus" "Intracellular and membrane" NA NA 130000 "Cluster 10: Basophils - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 38: EFO-21 - Unknown function" "Cluster 1: Pancreatic cells - Digestion" "Golgi apparatus" Nucleoplasm "CAB009499: AB_2105095, HPA067869: " "unprognostic (2.46e-1)" "unprognostic (2.73e-2)" "unprognostic (7.33e-2)" "unprognostic (2.30e-2)" "unprognostic (4.11e-3)" "unprognostic (4.37e-2)" "unprognostic (8.11e-2)" "prognostic unfavorable (1.58e-4)" "unprognostic (2.24e-1)" "unprognostic (9.92e-3)" "unprognostic (1.78e-1)" "unprognostic (1.96e-1)" "unprognostic (4.52e-3)" "unprognostic (4.57e-2)" "unprognostic (4.46e-2)" "unprognostic (4.27e-3)" "unprognostic (8.20e-2)" 54.5 24.4 12.8 36.4 10.5 73.8 42.4 10.6 14.5 26.4 11.7 32.8 27.6 32.3 9.8 33.7 30.4 19.4 58.5 14.9 9.0 56.8 305.6 63.2 13.0 12.5 10.8 22.4 108.6 27.3 45.9 40.6 11.3 60.1 12.1 12.9 220.5 17.7 61.3 62.7 35.5 14.3 10.4 51.4 34.0 8.6 15.6 11.8 56.1 25.3 11.2 30.2 33.3 9.3 50.8 31.2 6.8 29.8 49.4 32.1 77.5 64.4 48.1 26.3 18.1 45.4 54.3 1.9 148.8 47.5 46.1 91.5 14.0 32.5 5.4 148.0 35.2 90.9 52.8 57.7 26.2 13.0 141.2 35.6 35.3 29.5 13.2 62.4 84.7 14.6 70.5 8.5 17.8 32.3 5.0 29.2 21.5 44.2 9.3 7.9 26.6 10.9 35.2 39.1 13.1 9.2 54.5 28.5 42.5 31.9 10.7 31.4 125.9 29.4 60.1 43.7 95.5 15.2 93.4 3.4 55.8 40.1 60.7 2.0 0.9 1.5 0.7 0.1 0.2 0.4 0.2 0.3 0.6 0.1 0.0 0.1 0.7 0.4 0.0 0.3 0.0 1.1 12.8 10.5 10.6 14.5 14.9 9.0 12.5 10.8 11.3 10.4 15.6 9.3 44.1 3.2 27.4 4.2 7.3 19.4 10.0 10.4 2.8 12.8 12.0 9.0 16.3 21.5 8.5 22.0 25.0 20.9 26.9 49.5 0.0 47.1 0.5 15.2 9.7 29.4 37.8 26.5 7.9 117.5 16.5 11.4 21.9 32.3 15.8 7.0 23.9 131.8 24.8 8.4 7.5 31.7 10.2 35.3 42.1 1.4 11.1 33.6 16.0 5.6 14.0 13.6 24.7 2.0 4.4 108.3 26.4 10.9 7.2 24.3 28.7 7.8 2.0 28.0 26.3 10.5 18.6 2.8 3.6 8.5 23.0 84.3 19.6 4.7 17.9 16.4 GATD1 "FLJ34283, PDDC1" ENSG00000177225 "Glutamine amidotransferase like class 1 domain containing 1" Q8NB37 11 767220-777488 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 44.8;Alveolar cells type 2: 22.1;Collecting duct cells: 22.0;Theca cells: 25.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HEK 293: 120.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008812 Uncertain Supported Nucleoplasm "Secreted to blood" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 35: Non-specific - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "HPA008812: AB_10962724" "unprognostic (3.39e-1)" "unprognostic (2.48e-2)" "unprognostic (1.31e-1)" "unprognostic (3.58e-2)" "unprognostic (2.82e-2)" "unprognostic (3.03e-2)" "prognostic unfavorable (3.98e-4)" "unprognostic (3.50e-2)" "unprognostic (2.19e-1)" "unprognostic (5.67e-2)" "unprognostic (5.23e-3)" "unprognostic (4.89e-3)" "prognostic favorable (3.79e-5)" "unprognostic (2.84e-2)" "unprognostic (8.40e-2)" "unprognostic (6.11e-2)" "unprognostic (6.61e-3)" 15.9 37.5 37.7 11.3 35.8 7.9 16.7 35.1 37.8 22.7 36.6 23.3 15.4 24.9 12.6 23.7 22.7 7.3 16.3 37.4 36.5 24.0 19.3 15.4 11.2 46.4 41.8 25.9 15.9 10.5 30.1 9.2 35.8 23.0 6.5 9.7 17.5 12.2 14.4 21.0 18.2 7.9 38.4 19.6 17.8 18.6 45.3 8.8 22.0 6.5 6.8 19.7 20.4 37.5 41.3 22.3 22.2 23.9 10.2 15.6 20.9 24.2 10.5 22.0 19.3 15.8 62.5 22.1 8.6 16.0 23.2 42.7 16.7 21.6 11.0 28.1 120.5 13.0 38.8 36.0 17.5 25.4 27.8 22.4 23.2 9.3 14.2 19.9 17.1 25.8 34.2 20.0 12.4 11.0 29.3 27.5 21.3 13.4 42.8 31.4 15.1 28.0 19.2 9.1 56.9 22.3 22.9 32.0 16.6 5.7 28.5 16.8 31.3 23.2 17.5 12.7 18.8 23.4 12.9 28.4 35.4 33.9 19.6 1.0 5.2 0.9 2.9 6.6 2.1 2.7 3.0 2.9 6.9 2.3 2.4 1.7 0.5 1.2 2.6 4.0 1.4 2.0 37.7 35.8 35.1 37.8 37.4 36.5 46.4 41.8 35.8 38.4 45.3 37.5 8.7 44.8 22.1 0.0 4.4 0.0 0.0 0.0 0.0 0.0 11.9 10.4 0.0 0.0 7.4 22.0 0.0 13.8 5.2 0.0 5.9 10.3 0.0 11.8 15.2 3.8 0.0 0.0 0.0 7.6 7.9 8.5 0.0 9.6 6.3 19.2 0.0 0.0 13.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.2 0.0 0.0 4.6 0.0 0.0 0.0 0.0 16.6 0.0 0.0 1.3 0.0 0.0 14.7 7.3 0.0 0.0 0.0 5.8 0.0 0.0 0.0 0.0 9.6 3.9 25.8 0.0 0.0 GGH ENSG00000137563 "Gamma-glutamyl hydrolase" Q92820 8 63014881-63039407 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "kidney: 125.7;liver: 188.6" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 510.3;Early spermatids: 471.0;Extravillous trophoblasts: 273.4;Proximal tubular cells: 340.8;Syncytiotrophoblasts: 754.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "plasmacytoid DC: 30.6" "Lineage enriched" "Detected in all" 5 "dendritic cells: 30.6" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB019296, HPA025226" Approved "Intracellular and membrane" NA NA 1200000000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 2: Karpas-707 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "CAB019296: , HPA025226: AB_1849645" "unprognostic (9.29e-2)" "unprognostic (1.22e-1)" "unprognostic (5.48e-3)" "prognostic unfavorable (3.99e-7)" "unprognostic (5.57e-2)" "unprognostic (1.08e-1)" "unprognostic (1.14e-1)" "prognostic unfavorable (1.65e-4)" "unprognostic (1.95e-2)" "unprognostic (1.60e-1)" "unprognostic (2.11e-2)" "unprognostic (1.32e-1)" "unprognostic (1.69e-2)" "unprognostic (9.62e-3)" "unprognostic (1.50e-1)" "unprognostic (2.36e-1)" "unprognostic (6.50e-2)" 9.8 5.4 11.1 14.2 11.1 43.7 16.5 10.7 14.3 5.9 13.1 54.3 11.3 6.3 4.4 20.7 3.5 4.3 3.1 11.1 12.3 125.7 188.6 8.0 10.9 13.3 11.1 3.1 9.9 13.1 1.9 54.9 13.7 4.4 74.4 2.1 13.0 3.7 2.1 27.2 9.9 11.6 10.1 5.5 8.2 33.9 14.4 17.8 2.4 3.2 22.5 8.5 10.8 11.1 110.5 97.6 97.4 15.7 94.1 39.6 69.6 64.3 105.1 94.2 137.7 144.5 183.8 69.8 18.0 77.1 166.8 87.2 97.2 101.9 138.9 139.0 71.6 112.3 50.3 105.1 17.6 53.5 65.9 29.1 29.2 93.9 50.7 59.4 116.1 66.9 62.4 255.2 177.3 64.3 28.8 71.1 51.0 231.6 86.0 77.6 95.2 98.1 75.8 40.3 38.6 69.9 91.8 103.6 98.5 91.6 116.6 65.8 65.5 104.2 115.6 99.4 111.3 112.6 127.2 88.3 158.0 0.1 185.0 0.0 2.1 2.3 1.1 1.7 0.8 6.5 1.5 1.7 0.9 2.7 1.8 1.9 3.0 4.4 2.0 30.6 2.7 1.9 11.1 11.1 10.7 14.3 11.1 12.3 13.3 11.1 13.7 10.1 14.4 11.1 13.1 16.0 7.3 11.1 26.1 30.2 23.2 66.6 9.1 2.0 14.9 21.0 3.2 17.2 31.1 22.0 0.0 510.3 11.7 49.2 37.2 19.7 471.0 5.4 11.5 13.1 13.2 62.5 11.5 7.4 273.4 27.2 11.7 7.6 10.8 21.4 13.6 219.5 72.4 0.0 8.7 70.7 44.7 21.0 15.5 154.2 5.9 12.0 24.9 1.0 32.1 23.1 2.1 3.5 2.9 4.3 23.7 8.2 106.9 10.5 4.3 340.8 18.3 1.3 26.3 12.8 20.4 80.3 133.0 35.9 43.0 754.5 8.5 9.3 102.0 23.1 GZMA "CTLA3, HFSP" ENSG00000145649 "Granzyme A" P12544 5 55102646-55110252 "Enzymes, Predicted secreted proteins" Cytolysis "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 68.1" "Group enriched" "Detected in many" 24 "dendritic cells: 739.3;NK-cells: 1543.8;T-cells: 709.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Group enriched" "Detected in all" 15 "gdT-cell: 941.4;MAIT T-cell: 926.2;memory CD4 T-cell: 250.0;memory CD8 T-cell: 922.7;naive CD8 T-cell: 494.1;NK-cell: 718.8" "Group enriched" "Detected in all" 42 "NK-cells: 718.8;T-cells: 941.4" "Cell line enhanced" "Detected in some" "HL-60: 4.0;JURKAT: 2.9" "Not detected" "Not detected" "Not detected" "Not detected" "HPA054134, HPA076751" Enhanced "Secreted to blood" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 14: B-cells - Humoral immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 63: NK-cells & T-cells - Immune response" "HPA054134: AB_2682395, HPA076751: " "prognostic favorable (7.27e-4)" "unprognostic (7.29e-3)" "unprognostic (1.50e-2)" "prognostic favorable (6.44e-6)" "unprognostic (2.96e-3)" "unprognostic (1.85e-3)" "unprognostic (8.30e-3)" "unprognostic (1.15e-2)" "unprognostic (5.15e-3)" "unprognostic (3.03e-2)" "unprognostic (1.77e-1)" "unprognostic (3.09e-1)" "prognostic unfavorable (1.26e-6)" "unprognostic (5.91e-2)" "unprognostic (5.57e-1)" "unprognostic (5.73e-3)" "unprognostic (3.33e-3)" 5.6 6.0 0.9 16.7 0.9 35.3 7.2 0.9 2.5 7.6 1.2 14.7 29.2 14.7 8.8 4.8 4.6 14.0 4.0 0.8 1.0 3.2 15.2 21.9 68.1 1.6 0.9 4.5 1.0 1.3 1.0 3.1 1.1 3.1 17.8 0.0 7.1 3.0 1.7 1.6 27.6 7.2 1.1 51.1 11.7 2.0 1.1 12.4 2.9 1.3 19.2 13.5 2.9 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 3.3 2.5 3.8 941.4 2.3 926.2 3.4 250.0 922.7 3.1 1.3 48.5 494.1 19.9 718.8 4.0 3.2 33.1 712.7 0.9 0.9 0.9 2.5 0.8 1.0 1.6 0.9 1.1 1.1 1.1 1.1 5.1 3.2 18.1 0.0 12.3 0.4 0.1 0.0 2.8 0.0 2.7 2.4 1.6 5.7 3.1 0.0 0.0 0.4 739.3 1.4 0.0 1.6 0.0 1.7 2.7 2.8 0.0 36.2 0.0 0.0 0.2 7.8 20.4 2.1 7.6 0.0 17.9 2.8 0.3 0.0 0.1 1.5 0.0 25.8 2.6 0.0 0.0 12.3 3.6 0.0 12.6 0.0 1543.8 0.0 0.1 0.0 3.9 0.0 40.8 0.1 2.8 3.3 2.9 0.0 0.0 2.6 2.6 0.0 0.1 1.1 1.4 0.7 709.4 0.0 1.8 0.0 GZMB "CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT" ENSG00000100453 "Granzyme B" P10144 14 24630954-24634267 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Apoptosis, Cytolysis" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 68.2;lymphoid tissue: 37.1" "Group enriched" "Detected in many" 5 "dendritic cells: 2050.2;NK-cells: 1704.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 5 "plasmacytoid DC: 6765.2" "Lineage enriched" "Detected in all" 5 "dendritic cells: 6765.2" "Cell line enriched" "Detected in some" 6 "HMC-1: 22.0" "CAB000376, HPA003418" Enhanced "Secreted to blood" NA NA 2170 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 63: NK-cells & T-cells - Immune response" "CAB000376: AB_323716, HPA003418: AB_1079020" "prognostic favorable (7.27e-4)" "unprognostic (2.82e-3)" "unprognostic (8.54e-2)" "prognostic favorable (1.58e-5)" "unprognostic (2.07e-3)" "unprognostic (1.48e-3)" "unprognostic (4.43e-2)" "unprognostic (8.25e-2)" "unprognostic (3.70e-2)" "unprognostic (3.05e-3)" "unprognostic (4.26e-2)" "unprognostic (1.58e-1)" "prognostic unfavorable (1.10e-7)" "unprognostic (1.24e-1)" "unprognostic (1.48e-1)" "unprognostic (1.29e-1)" "unprognostic (2.71e-3)" 8.2 1.7 1.2 17.8 1.3 68.2 2.1 1.2 3.9 1.2 1.4 2.5 2.3 7.1 1.6 3.8 1.5 6.5 1.8 1.2 7.9 1.5 4.1 15.3 37.1 1.5 1.5 0.3 1.0 0.7 0.7 3.3 1.6 1.4 2.2 0.0 2.3 1.4 2.0 0.4 4.4 4.3 1.4 28.9 3.5 0.5 1.8 9.7 1.9 1.5 34.6 18.5 1.6 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.7 0.0 0.0 22.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 3.9 0.0 0.0 0.0 0.7 2.8 9.9 3.0 5.3 1338.5 4.0 16.0 7.0 95.2 641.6 6.3 3.1 29.1 607.5 43.1 507.8 6.0 6765.2 2.7 1607.1 1.2 1.3 1.2 3.9 1.2 7.9 1.5 1.5 1.6 1.4 1.8 1.3 4.3 6.4 36.0 0.0 15.9 2.8 0.3 0.0 0.0 0.0 0.9 0.8 1.1 4.3 7.4 0.0 0.0 0.4 2050.2 0.6 0.0 1.6 0.0 0.4 0.5 2.7 0.0 11.8 0.0 0.0 0.1 5.1 9.2 0.5 17.7 0.0 4.2 1.2 0.2 0.0 0.0 0.6 0.0 4.8 9.0 0.2 0.0 27.1 42.7 1.0 11.6 0.0 1704.4 0.0 0.1 0.1 2.3 0.0 86.8 0.2 0.6 3.1 4.4 0.0 0.0 1.3 1.3 0.0 0.1 0.4 4.1 0.3 373.8 0.0 0.6 0.1 GZMH "CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2" ENSG00000100450 "Granzyme H" P20718 14 24606480-24609699 "Enzymes, Predicted secreted proteins" Cytolysis "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 33.9;lymphoid tissue: 25.2" "Group enriched" "Detected in many" 10 "dendritic cells: 575.2;NK-cells: 492.3;T-cells: 302.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "gdT-cell: 1678.5;memory CD4 T-cell: 490.7;memory CD8 T-cell: 1389.6;naive CD8 T-cell: 1214.0" "Lineage enriched" "Detected in all" 7 "T-cells: 1678.5" "Cell line enhanced" "Detected in single" "U-266/70: 1.0" "Low region specificity" "Detected in many" HPA029200 Enhanced "Secreted to blood" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 2: Immune cells - Immune response" "Cluster 29: U-266 - Adaptive immune response" "Cluster 63: NK-cells & T-cells - Immune response" "HPA029200: AB_10602908" "unprognostic (3.72e-3)" "unprognostic (1.47e-3)" "unprognostic (5.35e-2)" "prognostic favorable (2.00e-6)" "unprognostic (8.80e-2)" "unprognostic (1.65e-3)" "unprognostic (2.08e-3)" "unprognostic (1.13e-1)" "unprognostic (1.62e-2)" "unprognostic (4.41e-2)" "unprognostic (1.14e-1)" "unprognostic (2.68e-1)" "prognostic unfavorable (1.74e-6)" "unprognostic (1.23e-1)" "unprognostic (1.80e-1)" "unprognostic (3.35e-2)" "unprognostic (2.77e-3)" 3.4 5.2 1.2 3.1 1.3 33.9 4.6 1.3 2.4 2.6 1.6 2.7 2.4 2.0 5.0 3.6 3.5 7.0 2.5 1.1 1.3 1.2 6.7 15.9 25.2 2.0 1.2 2.8 0.8 0.7 2.4 1.6 1.5 1.4 2.5 0.0 7.9 2.1 1.9 0.6 2.8 3.4 1.3 24.4 4.7 0.8 1.4 3.8 1.5 0.6 4.5 7.5 1.2 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.1 0.2 31.6 3.4 1.7 1678.5 3.6 30.2 7.6 490.7 1389.6 3.3 4.6 155.1 1214.0 18.6 250.8 5.4 44.6 4.5 1436.5 1.2 1.3 1.3 2.4 1.1 1.3 2.0 1.2 1.5 1.3 1.4 1.3 2.9 0.0 4.6 0.0 3.3 1.1 0.1 0.0 0.0 0.0 1.7 1.5 1.4 8.6 0.0 0.0 0.0 0.1 575.2 0.0 0.0 0.1 0.1 0.3 0.3 1.5 0.0 8.6 0.0 0.0 0.0 1.2 1.1 0.4 1.3 0.0 7.5 1.2 0.1 0.0 0.0 0.0 0.0 9.3 3.4 0.2 0.0 4.5 3.6 1.9 3.1 0.0 492.3 0.0 0.1 0.0 0.0 0.0 43.7 0.2 0.0 2.6 0.7 0.0 0.0 1.9 1.3 0.1 0.0 0.4 1.8 0.0 302.2 0.0 0.1 0.1 GZMK "PRSS, TRYP2" ENSG00000113088 "Granzyme K" P49863 5 55024256-55034570 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 9 "lymphoid tissue: 99.6" "Group enriched" "Detected in many" 4 "dendritic cells: 136.3;T-cells: 301.9" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Immune cell enhanced" "Detected in many" "MAIT T-cell: 741.6;NK-cell: 505.5" "Group enriched" "Detected in many" 199 "NK-cells: 505.5;T-cells: 741.6" "Cell line enriched" "Detected in single" 10 "JURKAT: 1.1" "Not detected" "Not detected" "Low region specificity" "Detected in single" "HPA063181, HPA065895" Enhanced "Secreted to blood" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" "HPA063181: AB_2684955, HPA065895: " "prognostic favorable (8.68e-4)" "unprognostic (3.26e-3)" "unprognostic (2.23e-2)" "unprognostic (1.83e-3)" "unprognostic (2.61e-2)" "unprognostic (1.12e-3)" "unprognostic (1.03e-3)" "unprognostic (8.13e-3)" "unprognostic (3.50e-2)" "unprognostic (4.53e-2)" "unprognostic (9.74e-2)" "unprognostic (1.96e-1)" "prognostic unfavorable (1.06e-4)" "unprognostic (2.04e-1)" "unprognostic (2.42e-1)" "unprognostic (1.21e-2)" "unprognostic (1.00e-1)" 3.0 3.9 0.1 19.4 0.1 10.5 4.9 0.1 0.4 4.3 0.3 3.4 1.6 4.0 4.5 3.0 2.0 11.6 2.0 0.1 0.2 1.7 10.7 5.9 99.6 0.5 0.2 2.7 1.0 0.8 0.5 0.5 0.3 3.2 4.6 0.0 4.6 1.0 0.2 0.6 7.3 2.2 0.2 30.4 6.5 1.2 0.3 11.9 2.3 0.3 27.8 8.0 1.9 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.9 1.1 164.3 1.0 741.6 0.5 100.2 457.3 0.5 0.5 4.9 77.4 3.1 505.5 0.9 0.9 7.0 95.5 0.1 0.1 0.1 0.4 0.1 0.2 0.5 0.2 0.3 0.2 0.3 0.3 3.8 3.2 7.0 0.0 10.7 1.5 0.1 0.0 1.8 0.0 1.5 1.7 0.1 2.8 0.6 0.0 0.0 0.0 136.3 0.1 0.0 0.0 1.3 0.8 0.4 0.8 0.0 4.4 0.0 0.0 0.0 1.2 4.1 0.8 2.5 0.0 8.6 1.5 0.2 0.0 0.0 0.0 0.0 10.3 2.5 1.2 0.0 6.4 1.8 0.0 5.1 0.0 29.9 0.0 0.1 0.0 0.0 0.0 45.1 0.1 0.2 0.8 0.0 0.0 0.0 1.8 1.7 0.0 0.3 0.2 0.6 0.3 301.9 0.0 0.0 0.1 GZMM "LMET1, MET1" ENSG00000197540 "Granzyme M" P51124 19 544034-549924 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Apoptosis, Cytolysis, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 21.6;lymphoid tissue: 22.7" "Group enriched" "Detected in many" 13 "dendritic cells: 385.8;NK-cells: 810.5;T-cells: 243.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "gdT-cell: 583.9" "Group enriched" "Detected in all" 33 "NK-cells: 194.9;T-cells: 583.9" "Cell line enhanced" "Detected in some" "EFO-21: 2.1;HDLM-2: 1.7;HMC-1: 2.1;JURKAT: 3.5;MOLT-4: 1.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA015624 Enhanced "Secreted to blood" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 2: Immune cells - Immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 63: NK-cells & T-cells - Immune response" "HPA015624: AB_2669245" "unprognostic (2.97e-3)" "unprognostic (2.29e-3)" "unprognostic (7.53e-2)" "prognostic favorable (1.89e-4)" "unprognostic (1.07e-1)" "prognostic favorable (1.87e-7)" "unprognostic (2.35e-1)" "unprognostic (7.46e-2)" "unprognostic (1.67e-1)" "unprognostic (4.98e-2)" "unprognostic (4.53e-2)" "unprognostic (7.94e-2)" "prognostic unfavorable (1.21e-4)" "unprognostic (1.32e-1)" "unprognostic (9.51e-2)" "unprognostic (2.69e-3)" "unprognostic (9.94e-2)" 2.2 1.1 0.9 10.0 0.9 21.6 1.1 3.6 2.0 1.4 0.3 1.5 2.1 0.8 0.2 0.8 1.3 1.8 0.8 0.9 0.9 1.0 3.3 5.3 19.2 1.0 0.8 0.7 0.4 0.0 0.9 0.4 1.0 1.3 0.3 0.2 2.8 0.4 0.7 0.8 6.2 0.2 0.7 22.7 3.7 1.8 0.9 8.7 1.6 0.1 3.8 1.5 1.4 1.0 0.0 0.3 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.1 0.0 0.2 0.1 0.0 0.1 2.1 0.1 0.0 0.0 0.0 0.0 0.0 3.5 0.7 0.1 0.0 0.4 1.3 0.6 0.3 0.1 0.3 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.0 0.4 0.1 0.5 0.1 0.3 0.1 9.1 1.4 1.3 583.9 1.7 366.5 0.9 189.2 471.3 1.5 4.0 182.8 379.2 11.9 194.9 2.3 3.6 99.1 227.5 0.9 0.9 3.6 2.0 0.9 0.9 1.0 0.8 1.0 0.7 0.9 1.0 3.4 0.0 0.0 0.3 5.7 3.1 0.1 0.0 0.6 0.5 2.4 2.2 0.1 1.5 0.0 0.0 0.0 0.2 385.8 0.1 0.0 0.4 0.9 0.6 1.5 1.4 0.0 12.0 0.3 0.4 0.4 2.2 13.3 1.1 0.0 0.1 3.6 1.4 0.2 0.0 0.2 0.4 0.0 3.7 4.7 1.6 0.0 5.9 1.8 1.0 8.6 1.6 810.5 0.5 0.3 0.3 0.0 0.0 35.8 0.1 0.0 1.2 0.0 1.4 0.0 1.5 1.2 0.5 1.1 0.9 1.4 0.5 243.6 0.2 0.1 0.1 HABP2 "FSAP, HABP, HGFAL, PHBP" ENSG00000148702 "Hyaluronan binding protein 2" Q14520 10 113550837-113589602 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 12 "liver: 437.3" "Group enriched" "Detected in some" 5 "Cholangiocytes: 124.4;Hepatocytes: 221.4" "Cancer enriched" "Detected in many" 5 "liver cancer: 92.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "OE19: 64.7;RPTEC TERT1: 50.9" "Not detected" "Not detected" "Not detected" "Not detected" HPA019518 Uncertain "Secreted to blood" NA NA 20200000000 4400000000 "Cluster 62: Liver - Hemostasis" "Cluster 21: OE19 - Mitochondria" "Cluster 15: Hepatocytes - Hemostasis" "HPA019518: AB_1850467" "unprognostic (3.89e-2)" "unprognostic (6.15e-2)" "unprognostic (1.33e-1)" "unprognostic (1.24e-1)" "unprognostic (1.45e-1)" "unprognostic (6.92e-2)" "unprognostic (1.01e-1)" "unprognostic (5.86e-3)" "unprognostic (1.67e-1)" "unprognostic (9.78e-2)" "unprognostic (5.10e-2)" "unprognostic (4.77e-2)" "unprognostic (9.18e-3)" "unprognostic (2.62e-3)" "unprognostic (2.11e-1)" "unprognostic (3.22e-1)" "unprognostic (9.05e-3)" 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.9 0.9 0.0 0.0 3.1 2.9 1.7 0.0 2.2 36.0 3.8 0.1 0.0 14.2 437.3 0.8 0.0 0.0 0.0 0.0 17.3 0.0 0.1 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.8 0.0 0.5 0.0 0.0 0.1 12.1 0.2 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.1 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.2 0.0 0.0 0.0 64.7 0.0 0.0 0.1 0.0 50.9 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.9 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 2.3 0.3 2.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 124.4 0.0 1.8 0.0 0.0 0.0 0.0 3.9 31.4 0.5 10.8 0.8 0.4 0.0 5.3 1.0 3.9 0.0 0.0 17.9 6.5 0.0 0.0 5.3 221.4 1.0 0.0 0.0 0.2 0.0 5.7 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.1 2.3 0.0 0.0 0.0 0.0 0.0 12.0 0.1 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.4 0.0 0.6 0.1 HGF "DFNB39, F-TCF, HGFB, HPTA, SF" ENSG00000019991 "Hepatocyte growth factor" P14210 7 81699010-81770438 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins, RAS pathway related proteins" "Growth factor, Serine protease homolog" "Cancer-related genes, Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 10 "placenta: 311.9" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 23.8;Fibroblasts: 95.8;Hepatic stellate cells: 25.0;Muller glia cells: 36.2;Smooth muscle cells: 26.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "basophil: 94.0" "Lineage enriched" "Detected in many" 5 "granulocytes: 94.0" "Cell line enhanced" "Detected in some" "ASC TERT1: 171.6;HHSteC: 135.8;HL-60: 82.4;hTEC/SVTERT24-B: 87.4;Karpas-707: 240.7;U-87 MG: 62.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "CAB010333, HPA040360, HPA044088" Approved "Secreted to blood" NA NA 4110000 14000 "Cluster 10: Basophils - Unknown function" "Cluster 28: Placenta - Pregnancy" "Cluster 2: Karpas-707 - Immune response" "Cluster 33: Fibroblasts - ECM organization" "CAB010333: AB_647965, HPA040360: AB_2676939, HPA044088: AB_2678804" "unprognostic (5.24e-2)" "unprognostic (6.77e-2)" "unprognostic (1.72e-2)" "unprognostic (5.12e-2)" "unprognostic (1.85e-2)" "unprognostic (7.45e-5)" "unprognostic (1.66e-1)" "unprognostic (9.28e-3)" "unprognostic (3.28e-2)" "unprognostic (2.97e-2)" "unprognostic (2.74e-1)" "unprognostic (5.29e-2)" "prognostic unfavorable (5.59e-4)" "unprognostic (7.90e-3)" "unprognostic (2.92e-2)" "unprognostic (1.14e-2)" "unprognostic (2.06e-2)" 7.9 19.8 1.6 6.3 3.3 12.3 5.2 1.5 7.8 7.2 1.8 4.4 2.6 8.1 3.6 2.9 5.4 16.6 4.7 2.9 3.6 11.8 30.3 19.5 2.2 3.6 2.3 1.8 2.1 2.1 2.4 311.9 4.3 7.2 3.4 14.2 2.4 6.4 0.8 0.9 2.3 7.1 1.8 6.5 3.9 2.4 2.9 1.5 5.6 3.9 1.5 10.4 6.3 3.3 0.0 0.0 0.1 0.0 21.6 171.6 0.1 0.7 33.4 0.1 0.1 0.0 0.0 0.0 0.0 0.8 0.2 0.2 0.0 0.0 0.0 0.0 0.1 6.0 0.0 0.0 135.8 82.4 0.4 41.4 0.0 87.4 0.3 0.0 2.2 0.0 0.1 240.7 0.6 0.0 0.0 56.4 0.0 0.0 0.2 0.8 0.0 7.5 0.0 0.0 0.2 9.3 0.0 0.1 0.0 0.2 0.0 3.5 0.4 2.0 0.0 0.1 0.0 0.1 0.0 0.0 62.6 16.9 0.1 94.0 15.2 3.9 0.0 18.7 0.0 0.0 0.0 0.0 4.8 0.0 0.0 0.0 3.2 0.0 17.3 1.0 0.0 4.3 1.6 3.3 1.5 7.8 2.9 3.6 3.6 2.3 4.3 1.8 2.9 3.3 6.2 0.0 4.1 16.3 0.0 1.0 0.2 0.0 1.8 0.2 0.3 0.5 1.3 1.5 0.6 0.0 0.0 5.6 0.0 0.0 0.0 0.0 15.2 1.0 23.8 6.2 0.0 2.1 0.3 0.0 4.9 95.8 0.5 0.9 1.3 0.0 25.0 0.5 18.4 0.0 22.4 0.0 0.0 12.5 1.9 2.3 18.3 14.0 1.8 7.5 10.5 36.2 1.0 0.0 0.1 0.0 0.0 10.9 0.3 0.4 0.0 0.0 0.0 0.7 13.1 0.9 26.2 0.2 0.3 0.3 0.1 12.0 0.6 1.3 0.0 0.4 HGFAC "HGFA, HGFAP" ENSG00000109758 "HGF activator" Q04756 4 3441968-3449486 "Cancer-related genes, Enzymes, Plasma proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 56 "liver: 217.1" "Group enriched" "Detected in some" 5 "Early spermatids: 85.6;Hepatocytes: 72.0;Late spermatids: 165.9" "Cancer enriched" "Detected in some" 22 "liver cancer: 26.7" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 9 "Hep G2: 5.7" "Not detected" "Not detected" "Low region specificity" "Detected in some" "HPA058279, HPA059076" Enhanced "Secreted to blood" NA NA 7590000 9300000000 "Cluster 62: Liver - Hemostasis" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 34: Spermatids - Unknown function" "HPA058279: AB_2683665, HPA059076: AB_2683898" "unprognostic (2.70e-2)" "unprognostic (8.20e-2)" "unprognostic (1.57e-1)" "unprognostic (1.86e-1)" "unprognostic (1.36e-1)" "unprognostic (1.39e-2)" "unprognostic (2.85e-3)" "unprognostic (5.37e-3)" "unprognostic (5.90e-2)" "unprognostic (1.81e-1)" "unprognostic (8.54e-3)" "unprognostic (5.52e-2)" "prognostic unfavorable (9.31e-4)" "unprognostic (2.87e-1)" "unprognostic (2.24e-1)" "unprognostic (9.49e-2)" "unprognostic (3.74e-4)" 0.0 0.0 1.5 0.0 2.3 0.0 0.1 2.2 2.6 0.5 0.7 0.2 0.0 0.2 0.2 0.0 0.3 0.0 0.1 1.3 0.6 0.6 217.1 0.1 0.0 0.9 0.6 0.1 0.1 0.0 0.7 0.0 0.9 0.3 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.5 0.1 0.1 3.8 0.8 0.0 0.1 0.0 0.0 0.1 0.1 0.6 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 5.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.1 0.0 0.6 0.4 0.2 0.0 0.0 0.0 0.2 0.5 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 2.3 2.2 2.6 1.3 0.6 0.9 0.6 0.9 0.5 0.8 0.6 0.1 0.0 0.0 1.3 0.2 0.5 0.1 0.0 0.0 0.0 0.2 0.0 0.5 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 85.6 0.5 0.2 0.2 0.0 0.0 0.2 0.0 0.2 0.1 0.0 0.4 0.0 4.4 2.2 72.0 0.0 3.3 3.9 0.0 0.0 3.2 0.0 165.9 0.0 0.1 0.0 0.0 0.0 1.1 0.0 0.5 0.3 0.0 0.0 1.2 0.0 0.2 0.0 0.4 0.0 0.1 0.0 0.0 0.1 21.5 1.2 0.0 0.0 0.0 0.1 0.1 0.0 0.1 HM13 "dJ324O17.1, H13, IMP1, IMPAS, PSENL3, PSL3, SPP, SPPL1" ENSG00000101294 "Histocompatibility minor 13" Q8TCT9 20 31514410-31577923 "Enzymes, Plasma proteins, Predicted membrane proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hofbauer cells: 324.9;Plasma cells: 400.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045089, HPA056062" Enhanced Supported "Endoplasmic reticulum" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 25: RPMI-8226 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" "Endoplasmic reticulum" "HPA045089: AB_10962054, HPA056062: AB_2683022" "unprognostic (8.03e-2)" "unprognostic (2.11e-2)" "unprognostic (5.03e-2)" "unprognostic (1.59e-1)" "unprognostic (2.82e-1)" "unprognostic (5.87e-3)" "prognostic unfavorable (1.95e-5)" "unprognostic (2.66e-2)" "unprognostic (2.14e-2)" "unprognostic (2.55e-1)" "unprognostic (2.30e-1)" "unprognostic (8.10e-2)" "prognostic unfavorable (4.64e-12)" "unprognostic (3.77e-2)" "unprognostic (1.57e-1)" "unprognostic (1.85e-1)" "unprognostic (8.17e-2)" 78.6 102.9 10.5 60.9 13.5 61.7 63.4 13.6 15.7 100.0 42.4 54.5 52.6 72.9 111.4 128.6 70.4 46.7 55.9 12.5 17.1 61.4 136.1 83.7 40.7 17.8 17.9 59.2 241.1 68.8 90.0 64.6 17.4 66.0 44.4 20.8 217.7 80.3 44.6 51.6 52.1 49.1 14.2 70.2 92.5 21.9 23.9 30.5 74.7 14.1 54.2 64.9 72.2 20.9 143.8 147.6 56.6 87.7 260.2 163.5 197.6 239.0 221.3 159.7 162.8 287.3 166.8 90.4 312.8 262.7 209.7 253.8 74.9 162.0 97.7 46.2 112.0 201.3 99.7 179.3 287.0 118.1 78.1 152.5 103.5 133.7 182.7 159.0 124.5 56.0 90.2 364.0 148.8 170.3 100.0 84.0 67.8 234.9 248.5 63.6 272.6 436.5 154.4 75.6 76.3 90.4 243.5 234.9 199.2 56.4 182.0 109.5 153.3 243.1 129.8 246.3 136.2 225.5 145.5 71.7 328.7 413.0 219.4 117.7 380.9 190.8 116.7 372.6 159.7 91.9 108.0 112.9 260.8 74.4 70.6 84.1 282.8 117.5 363.7 271.9 104.1 374.1 10.5 13.5 13.6 15.7 12.5 17.1 17.8 17.9 17.4 14.2 23.9 20.9 67.4 51.3 55.4 23.8 78.2 33.4 59.0 127.8 31.3 45.4 65.6 49.1 13.6 71.4 102.2 53.3 123.0 154.0 70.7 115.2 13.7 145.6 15.5 55.0 111.5 60.9 61.5 38.9 40.5 169.7 139.0 93.2 80.0 128.4 42.4 55.5 53.2 86.4 324.9 43.7 39.2 134.5 63.1 81.2 83.1 15.9 60.6 106.1 65.8 28.1 77.4 52.2 53.5 33.7 23.8 144.3 81.2 43.6 400.6 92.4 54.8 51.0 49.3 44.8 32.9 49.2 79.2 26.1 26.4 60.0 35.4 213.6 60.1 97.2 70.8 69.3 HP ENSG00000257017 Haptoglobin P00738 16 72054505-72061055 "Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Acute phase, Immunity" "Antibiotic, Antimicrobial, Antioxidant, Serine protease homolog" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 91 "liver: 61113.6" "Cell type enriched" "Detected in many" 43 "Hepatocytes: 59512.7" "Cancer enriched" "Detected in many" 81 "liver cancer: 1297.4" "Region enhanced" "Detected in all" "medulla oblongata: 29.7" "Group enriched" "Detected in many" 5 "classical monocyte: 49.3;eosinophil: 80.2" "Group enriched" "Detected in many" 7 "granulocytes: 80.2;monocytes: 49.3" "Group enriched" "Detected in some" 5 "Hep G2: 232.2;HSkMC: 121.4" "CAB003787, HPA047750, HPA066795" Enhanced Approved Vesicles "Secreted to blood" NA NA 998000000000 100000000000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 15: Hepatocytes - Hemostasis" Vesicles "CAB003787: , HPA047750: AB_2680146, HPA066795: " "unprognostic (6.38e-3)" "unprognostic (7.73e-3)" "unprognostic (1.23e-1)" "unprognostic (2.41e-2)" "unprognostic (2.34e-3)" "unprognostic (2.07e-1)" "unprognostic (7.79e-3)" "unprognostic (1.37e-1)" "unprognostic (2.31e-1)" "unprognostic (1.84e-1)" "unprognostic (6.30e-2)" "unprognostic (8.18e-2)" "prognostic unfavorable (6.94e-13)" "unprognostic (4.34e-4)" "unprognostic (1.80e-1)" "unprognostic (6.61e-2)" "unprognostic (2.49e-2)" 673.1 11.4 1.3 26.9 1.7 231.5 34.2 1.4 2.9 71.9 3.6 3.6 1.5 3.5 2.9 5.3 74.6 1.3 146.7 1.4 1.4 19.8 61113.6 91.3 1.7 29.7 2.0 9.9 7.6 0.2 49.9 2.5 3.7 7.3 0.6 0.7 6.1 0.2 5.0 3.4 4.4 4.5 2.3 72.0 6.2 2.1 8.3 2.7 6.3 0.4 3.0 3.8 3.3 5.9 0.0 0.0 0.0 0.0 6.6 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.3 8.5 0.3 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.0 11.2 0.2 232.2 0.3 33.3 6.2 121.4 0.0 0.0 0.0 0.0 0.0 0.0 8.8 0.0 0.0 0.0 2.0 0.4 2.6 0.0 0.0 1.1 23.6 0.0 0.0 0.1 0.0 0.0 16.2 0.0 0.0 0.0 0.0 6.8 5.1 0.0 0.8 0.0 0.0 3.9 0.0 14.1 0.0 12.7 0.0 6.2 49.3 80.2 0.0 2.0 0.0 0.0 0.0 0.0 8.7 0.0 0.0 0.0 14.2 0.0 2.1 0.0 0.0 15.2 1.3 1.7 1.4 2.9 1.4 1.4 29.7 2.0 3.7 2.3 8.3 5.9 0.4 19.2 228.7 1.6 96.1 0.1 0.7 1.9 0.0 0.4 0.4 0.3 66.6 1085.2 8.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.4 0.1 56.7 0.0 1128.3 0.0 10.4 0.1 45.5 0.0 1.3 3.8 0.4 1038.7 59512.7 2.3 0.0 0.0 0.2 4.1 1381.4 0.0 0.5 10.2 7.8 1.8 0.0 0.3 1.5 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.8 0.0 1.5 7.5 0.2 0.0 2.6 1.8 0.0 0.0 0.1 0.3 0.1 90.3 0.0 0.3 0.1 HPN TMPRSS1 ENSG00000105707 Hepsin P05981 19 35040506-35066573 "Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 200.5;liver: 866.2;pancreas: 272.1" "Group enriched" "Detected in many" 6 "Hepatocytes: 442.2;Proximal tubular cells: 201.0" "Cancer enhanced" "Detected in many" "liver cancer: 127.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 9 "EFO-21: 31.5;Hep G2: 47.8;T-47d: 22.1" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" HPA006804 Approved NA NA 3300000 "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA006804: AB_1079046" "unprognostic (6.74e-3)" "unprognostic (6.00e-2)" "unprognostic (4.10e-2)" "unprognostic (1.16e-1)" "unprognostic (2.72e-1)" "unprognostic (9.96e-2)" "unprognostic (4.22e-3)" "unprognostic (1.27e-1)" "unprognostic (4.13e-3)" "unprognostic (9.54e-2)" "unprognostic (3.54e-1)" "unprognostic (1.16e-1)" "prognostic favorable (5.45e-5)" "unprognostic (1.22e-1)" "unprognostic (1.52e-1)" "unprognostic (1.12e-1)" "unprognostic (7.96e-2)" 1.8 0.9 5.6 0.2 8.8 0.0 11.6 7.0 7.2 1.6 4.2 1.1 1.4 4.0 3.9 0.3 7.4 4.0 5.1 5.7 6.5 200.5 866.2 11.8 0.4 7.5 8.1 1.3 272.1 24.2 14.8 0.5 7.5 20.1 0.3 0.3 15.6 4.7 22.1 0.9 1.1 0.2 6.5 2.6 58.2 1.3 7.6 0.2 19.9 5.4 0.1 0.6 0.4 11.7 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 3.5 0.0 0.1 31.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 47.8 0.2 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.3 0.0 0.0 0.2 0.3 0.1 0.0 0.0 3.2 0.2 0.1 0.0 0.2 0.5 22.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 5.6 8.8 7.0 7.2 5.7 6.5 7.5 8.1 7.5 6.5 7.6 11.7 0.5 9.6 32.4 8.8 3.0 0.1 5.1 0.0 0.0 7.2 12.0 8.9 3.4 51.5 1.3 33.1 0.0 0.1 0.0 0.1 52.8 7.5 8.9 4.9 1.0 1.1 2.4 10.7 2.3 26.5 0.3 1.9 18.3 12.5 2.5 0.1 8.6 442.2 1.1 0.0 1.7 2.4 0.0 9.7 0.3 26.0 0.0 1.8 0.0 2.8 0.6 1.6 0.0 0.0 41.6 14.4 0.0 0.4 0.0 7.5 0.0 201.0 0.0 0.6 0.0 0.2 0.2 0.0 0.4 0.0 0.0 0.8 1.8 0.1 0.1 0.5 HPR ENSG00000261701 "Haptoglobin-related protein" P00739 16 72063148-72077246 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Serine protease homolog" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "liver: 811.9" "Group enriched" "Detected in some" 14 "Hepatocytes: 503.0;Smooth muscle cells: 128.8" "Cancer enriched" "Detected in some" 53 "liver cancer: 185.1" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 15 "Hep G2: 50.6" HPA047750 Supported Approved Vesicles "Secreted to blood" NA NA 49000000000 55000000000 "Cluster 35: T-regs - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 10: Non-specific - Unknown function" Vesicles "HPA047750: AB_2680146" "unprognostic (2.43e-1)" "unprognostic (4.69e-2)" "unprognostic (5.97e-3)" "unprognostic (2.42e-1)" "unprognostic (2.32e-3)" "unprognostic (2.36e-1)" "unprognostic (1.66e-1)" "unprognostic (8.21e-2)" "unprognostic (2.30e-1)" "unprognostic (3.44e-6)" "unprognostic (2.09e-2)" "unprognostic (1.45e-1)" "unprognostic (1.29e-1)" 5.5 0.5 14.1 0.2 15.3 0.1 2.0 13.9 16.7 1.2 11.3 1.2 0.6 0.3 0.4 0.3 1.3 0.7 137.2 13.7 14.3 4.0 811.9 1.5 0.7 14.4 14.3 2.0 0.6 0.0 0.3 0.0 13.6 1.6 0.1 0.8 0.3 0.3 1.7 0.6 1.1 0.1 12.8 0.3 1.7 1.9 15.2 0.2 1.1 0.2 0.1 0.4 1.9 13.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 50.6 2.2 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.2 0.2 0.0 0.1 0.1 0.1 0.0 0.2 0.4 0.2 0.0 0.1 0.0 0.6 0.6 0.0 14.1 15.3 13.9 16.7 13.7 14.3 14.4 14.3 13.6 12.8 15.2 13.1 0.0 0.0 7.5 2.3 0.4 0.1 0.0 0.9 0.0 0.1 0.0 0.0 22.4 12.8 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.8 0.0 5.3 0.2 0.2 0.0 2.6 0.0 0.0 0.0 1.1 10.8 503.0 0.0 0.0 0.2 0.0 2.0 12.8 0.0 2.8 9.9 0.0 0.0 0.0 0.0 4.9 0.0 0.0 1.2 0.0 0.0 5.3 0.0 0.0 0.0 13.0 0.2 0.1 0.0 6.1 128.8 0.0 0.0 0.0 0.0 0.0 0.7 0.5 0.2 0.0 HTRA1 "ARMD7, HtrA, IGFBP5-protease, PRSS11" ENSG00000166033 "HtrA serine peptidase 1" Q92743 10 122458551-122514907 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Growth factor binding, Hydrolase, Protease, Serine protease" "Age-related macular degeneration, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Fibroblasts: 269.3;Granulosa cells: 731.6;Horizontal cells: 625.9;Muller glia cells: 373.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 2417.8;ASC TERT1: 889.4;fHDF/TERT166: 862.3;HSkMC: 1581.4;LHCN-M2: 1238.2;U-87 MG: 1004.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036655 Approved Supported "Plasma membrane" "Secreted to blood" NA NA 24800000 7600000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 68: Epididymis - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 40: Granulosa cells - Unknown function" "Plasma membrane" "HPA036655: AB_10671966" "unprognostic (3.84e-1)" "unprognostic (3.42e-2)" "unprognostic (1.57e-2)" "unprognostic (1.86e-2)" "unprognostic (1.22e-3)" "unprognostic (8.71e-3)" "unprognostic (2.33e-2)" "unprognostic (3.83e-1)" "unprognostic (7.22e-2)" "unprognostic (3.36e-2)" "unprognostic (1.32e-1)" "unprognostic (1.54e-1)" "prognostic unfavorable (7.90e-7)" "unprognostic (7.12e-3)" "unprognostic (9.13e-2)" "unprognostic (1.69e-1)" "prognostic unfavorable (5.62e-6)" 246.0 81.3 382.1 37.0 436.6 0.5 202.8 422.6 595.7 352.1 316.2 154.8 20.8 197.1 247.1 57.8 122.9 301.2 114.7 377.7 411.4 230.9 226.4 69.9 39.9 427.1 447.0 425.5 55.9 111.8 184.1 281.9 425.3 85.7 51.8 243.6 101.1 114.5 31.1 130.5 73.5 152.3 382.1 54.2 87.3 19.5 423.6 21.2 78.8 80.9 27.3 137.3 188.3 464.2 0.3 45.6 19.4 5.7 2417.8 889.4 0.8 108.3 196.8 44.4 23.6 0.2 0.6 0.0 29.0 862.3 68.6 12.8 7.6 124.4 6.2 0.1 4.9 0.1 65.4 0.3 123.7 0.1 0.9 1581.4 444.6 25.8 205.3 503.6 207.1 0.0 0.1 1.5 1238.2 22.3 0.1 0.7 20.9 0.2 67.6 0.2 1.3 0.4 282.6 2.2 1.2 3.9 272.1 0.2 122.2 91.4 8.6 0.2 136.0 309.9 4.5 141.3 94.1 0.2 0.1 0.3 1004.6 0.2 148.5 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 382.1 436.6 422.6 595.7 377.7 411.4 427.1 447.0 425.3 382.1 423.6 464.2 55.1 22.4 6.9 116.5 0.9 44.1 32.5 10.8 23.9 53.3 5.4 31.2 26.4 14.3 0.9 64.4 54.2 30.9 1.3 0.0 0.0 2.0 3.5 11.3 76.5 107.0 0.0 2.7 2.2 4.6 164.6 269.3 4.6 14.4 1.3 731.6 57.8 157.8 51.3 625.9 31.2 0.3 8.2 18.1 59.9 4.2 31.7 22.0 46.2 86.2 8.5 373.8 0.0 193.0 112.5 2.7 1.3 77.5 1.9 8.7 0.2 22.6 10.1 150.3 6.6 63.3 140.5 0.2 0.7 7.0 30.5 87.7 7.2 2.5 0.6 11.9 HTRA2 "OMI, PARK13, PRSS25" ENSG00000115317 "HtrA serine peptidase 2" O43464 2 74529725-74533332 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins" Apoptosis "Hydrolase, Protease, Serine protease" "Disease variant, Epilepsy, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Erythroid cells: 118.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004004, HPA006602, HPA027366" Uncertain Supported Mitochondria NA NA 260000 "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 39: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 10: Non-specific - Unknown function" Mitochondria "CAB004004: AB_326421, HPA006602: AB_2667622, HPA027366: AB_1851301" "unprognostic (3.09e-1)" "unprognostic (4.06e-2)" "unprognostic (2.82e-1)" "unprognostic (2.58e-2)" "unprognostic (1.56e-1)" "unprognostic (1.37e-1)" "prognostic unfavorable (7.77e-8)" "unprognostic (2.12e-3)" "unprognostic (4.18e-1)" "unprognostic (1.15e-1)" "unprognostic (4.57e-2)" "unprognostic (8.15e-2)" "unprognostic (7.23e-3)" "unprognostic (4.03e-1)" "unprognostic (1.73e-1)" "unprognostic (1.72e-1)" "unprognostic (2.06e-2)" 11.4 8.6 8.1 8.1 8.7 11.1 6.8 9.1 9.7 7.1 7.7 6.4 6.9 6.9 1.0 6.0 7.1 4.7 9.4 8.1 8.3 8.1 6.5 6.6 7.8 8.6 8.5 10.9 7.4 9.4 4.7 6.3 8.3 4.8 3.3 2.5 8.5 5.3 14.5 5.4 7.9 5.3 8.2 9.9 6.4 6.2 9.6 9.1 6.8 9.0 4.8 6.5 5.8 9.2 19.1 14.7 14.7 12.6 21.3 9.0 30.1 17.0 10.3 10.3 7.0 21.1 8.5 16.6 12.9 10.7 26.0 19.7 12.0 19.6 2.4 34.0 31.4 33.3 10.8 19.0 19.8 15.3 22.4 9.9 13.7 18.4 19.5 18.4 14.2 23.5 43.9 24.9 9.7 14.1 22.0 31.1 10.0 22.8 37.7 15.8 37.0 17.1 9.6 8.2 15.1 17.7 8.9 18.6 32.5 7.3 9.3 13.2 10.6 19.2 19.7 33.4 35.3 29.5 10.2 9.8 13.6 23.4 13.0 5.8 7.0 4.0 4.8 5.7 5.8 11.0 4.8 4.1 8.6 9.9 4.3 4.1 2.6 5.0 4.5 4.5 5.7 5.5 8.1 8.7 9.1 9.7 8.1 8.3 8.6 8.5 8.3 8.2 9.6 9.2 30.7 0.0 4.8 6.2 27.3 20.6 19.7 33.8 13.6 12.0 17.4 21.7 0.9 21.5 15.7 11.0 0.0 24.7 25.8 12.5 35.2 32.4 30.8 11.9 18.1 29.6 9.0 118.5 6.3 17.7 37.8 23.3 11.2 12.9 27.3 20.9 22.9 12.7 31.5 10.1 6.3 12.3 20.3 10.7 19.4 48.9 24.8 14.6 30.2 2.8 26.3 20.2 30.9 5.5 7.5 26.1 16.8 20.7 36.0 21.3 24.8 36.8 13.5 16.3 26.3 18.7 56.5 64.3 43.3 16.7 22.0 20.2 20.6 27.1 20.0 15.7 HTRA3 "Prsp, Tasp" ENSG00000170801 "HtrA serine peptidase 3" P83110 4 8269754-8307098 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 194.9" "Cell type enhanced" "Detected in some" "Fibroblasts: 158.8;Leydig cells: 43.5;Peritubular cells: 42.9;Skeletal myocytes: 99.0;Theca cells: 25.2" "Cancer enhanced" "Detected in all" "pancreatic cancer: 67.7" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in many" 5 "U-2197: 182.1" "Low region specificity" "Detected in all" "Region enhanced" "Detected in many" "spinal cord: 10.3" "HPA021187, HPA063810" Approved Approved Vesicles "Secreted in other tissues" NA NA "Cluster 46: Fibroblasts - ECM organization" "Cluster 18: U-2197 - ECM organization" "Cluster 50: Fibroblasts - ECM organization" Vesicles "HPA021187: AB_1851311, HPA063810: AB_2685129" "unprognostic (5.87e-2)" "unprognostic (1.40e-2)" "unprognostic (2.89e-2)" "unprognostic (9.32e-2)" "unprognostic (1.84e-1)" "unprognostic (3.09e-2)" "unprognostic (1.12e-3)" "unprognostic (5.29e-2)" "unprognostic (3.81e-2)" "unprognostic (1.15e-1)" "unprognostic (1.95e-2)" "unprognostic (2.79e-1)" "prognostic unfavorable (1.61e-9)" "unprognostic (1.65e-3)" "unprognostic (2.56e-2)" "prognostic unfavorable (1.29e-4)" "unprognostic (1.34e-2)" 68.0 6.0 0.9 8.7 1.3 13.4 50.4 0.9 1.3 35.4 5.0 33.9 8.7 42.4 10.6 15.1 26.2 35.5 194.9 0.9 1.0 6.2 3.2 38.0 1.2 1.0 1.0 93.0 6.8 0.4 15.7 20.4 1.0 26.3 4.8 0.1 22.8 6.7 32.1 28.1 16.9 11.8 1.0 2.9 21.9 4.3 1.7 2.2 26.0 12.9 0.7 62.4 32.6 0.7 0.0 1.0 1.4 0.0 5.8 10.8 0.3 2.4 0.2 2.8 0.6 0.1 0.1 0.0 13.6 6.4 1.4 0.1 1.2 0.0 0.9 0.0 2.3 1.3 13.9 0.0 6.1 0.0 0.6 1.2 0.0 4.2 0.0 1.7 9.8 0.0 0.3 0.0 10.2 0.0 0.2 36.5 6.1 0.0 0.3 0.3 0.0 0.1 0.0 0.0 15.8 0.3 26.4 0.5 0.2 28.8 0.1 1.1 8.1 1.4 4.7 182.1 0.0 1.3 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.9 1.3 0.9 1.3 0.9 1.0 1.0 1.0 1.0 1.0 1.7 0.7 12.6 0.0 0.0 0.0 0.0 5.2 0.5 0.0 0.6 0.0 0.5 0.9 16.5 0.0 0.6 0.0 0.0 0.8 0.1 0.0 0.0 0.1 1.2 0.3 8.1 5.3 0.0 0.0 0.0 0.0 4.2 158.8 0.5 0.3 0.0 6.0 3.3 0.0 1.4 0.0 0.0 0.0 0.0 0.0 8.6 1.4 43.5 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 42.9 0.4 0.4 0.0 0.1 0.0 0.0 0.0 99.0 10.6 0.4 0.7 0.6 5.3 1.4 0.9 25.2 0.0 0.2 HTRA4 FLJ90724 ENSG00000169495 "HtrA serine peptidase 4" P83105 8 38974228-38988663 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 9 "placenta: 67.0" "Cell type enriched" "Detected in some" 10 "Extravillous trophoblasts: 444.0" "Cancer enhanced" "Detected in some" "testis cancer: 2.5" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 24 "BEWO: 233.6" "Region enhanced" "Detected in single" "hippocampal formation: 2.1" "Low region specificity" "Detected in all" HPA045402 Enhanced "Secreted in female reproductive system" NA NA 23000 "Cluster 17: Basophils - Unknown function" "Cluster 28: Placenta - Pregnancy" "Cluster 28: BEWO - Transcription regulation" "Cluster 38: Extravillous trophoblasts - Unknown function" "HPA045402: AB_2679316" "unprognostic (1.20e-1)" "unprognostic (5.83e-4)" "unprognostic (8.02e-2)" "unprognostic (2.13e-2)" "unprognostic (8.20e-2)" "unprognostic (2.42e-2)" "unprognostic (1.80e-1)" "unprognostic (7.40e-3)" "unprognostic (1.40e-1)" "unprognostic (5.14e-4)" "unprognostic (1.01e-1)" "unprognostic (8.68e-2)" "unprognostic (1.42e-1)" "unprognostic (4.58e-1)" "unprognostic (5.19e-3)" "unprognostic (2.39e-3)" "unprognostic (1.19e-3)" 0.8 0.5 0.8 0.8 1.2 7.2 1.2 3.5 5.0 0.9 0.0 0.5 0.3 0.9 0.9 0.1 0.3 0.5 0.3 1.3 0.9 0.4 0.5 2.0 2.5 0.6 0.5 0.6 0.8 0.5 0.1 67.0 0.6 0.6 0.7 1.8 0.3 1.1 1.0 0.8 0.4 0.7 0.1 1.2 0.4 0.9 1.4 0.5 0.5 0.1 1.7 0.4 0.1 2.0 0.4 0.3 0.2 0.4 0.8 0.4 233.6 0.6 0.4 0.3 0.4 0.4 0.5 0.5 0.2 0.2 0.4 0.4 0.2 0.2 0.1 0.2 0.4 0.4 0.7 0.3 0.2 0.6 0.6 0.7 0.2 0.2 0.5 0.3 0.2 0.2 0.4 1.3 0.2 0.5 0.4 0.3 0.3 0.1 0.2 0.2 0.2 0.4 0.2 0.7 0.4 0.6 0.5 0.3 0.1 9.6 0.5 0.7 0.0 0.7 0.5 0.3 0.3 0.5 0.2 0.2 0.2 0.7 0.2 0.3 0.1 0.4 0.2 0.1 0.3 0.2 0.2 0.2 0.1 0.5 0.2 0.2 0.5 0.2 0.2 0.5 0.3 0.0 0.8 1.2 3.5 5.0 1.3 0.9 0.6 0.5 0.6 0.1 1.4 2.0 0.1 0.0 0.0 0.0 1.0 0.1 1.7 0.1 1.2 0.5 0.1 0.3 0.7 0.0 0.0 0.0 2.1 2.8 1.1 0.1 0.0 0.0 0.1 0.2 0.7 0.3 0.0 0.0 0.4 0.0 444.0 1.2 0.0 0.5 0.0 0.7 1.4 0.0 11.6 1.7 0.2 0.0 0.0 0.6 0.3 0.0 0.0 3.8 1.8 1.0 0.0 0.4 1.0 1.5 0.2 0.3 0.0 0.0 0.5 1.5 0.0 0.2 0.1 0.2 0.0 3.5 0.2 0.0 0.1 0.0 0.1 40.4 0.7 0.2 0.2 1.1 IDE ENSG00000119912 "Insulin degrading enzyme" P14735 10 92451684-92574096 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Host-virus interaction" "Allosteric enzyme, Host cell receptor for virus entry, Hydrolase, Metalloprotease, Protease, Receptor" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063478 Approved "Secreted in other tissues" NA NA 310000 "Cluster 27: Non-specific - Gene expression" "Cluster 31: Skin - Epidermis development" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA063478: AB_2685020" "unprognostic (1.70e-1)" "unprognostic (6.40e-2)" "prognostic favorable (3.69e-4)" "prognostic favorable (3.53e-4)" "unprognostic (2.54e-1)" "unprognostic (1.78e-1)" "unprognostic (2.51e-1)" "unprognostic (3.79e-1)" "unprognostic (8.88e-2)" "unprognostic (2.57e-1)" "unprognostic (6.58e-2)" "unprognostic (7.79e-2)" "unprognostic (6.81e-2)" "unprognostic (9.24e-3)" "unprognostic (6.13e-2)" "unprognostic (3.89e-2)" "unprognostic (3.91e-1)" 6.7 10.1 3.4 2.8 3.6 3.5 6.1 3.7 4.2 8.1 5.9 8.6 3.3 7.4 9.7 9.8 6.5 2.9 11.7 3.4 3.7 5.9 11.4 5.9 3.4 3.8 3.7 5.4 12.3 9.5 4.7 2.7 3.9 9.1 3.8 10.3 7.8 4.2 28.8 36.4 6.8 3.7 3.6 6.3 8.2 25.8 3.6 2.4 6.7 9.7 4.1 8.9 7.9 3.8 12.1 22.9 6.2 15.1 10.5 5.8 8.5 10.4 13.3 6.1 5.2 19.4 9.5 12.5 16.4 14.3 7.2 16.3 14.6 10.0 3.9 14.7 8.8 5.1 13.7 25.9 11.5 14.9 6.5 5.4 6.6 9.1 14.0 7.8 8.6 3.3 10.0 8.1 5.4 18.0 6.6 8.8 10.2 10.4 5.2 10.2 10.8 9.0 10.9 19.3 2.2 5.6 14.3 6.4 6.7 6.8 12.6 6.3 15.3 4.4 8.2 5.0 10.4 11.2 12.2 14.5 6.9 10.9 4.4 0.3 3.5 1.4 2.0 4.2 2.2 2.9 2.6 2.9 4.6 2.1 1.9 2.0 0.0 3.7 5.9 1.3 3.9 2.3 3.4 3.6 3.7 4.2 3.4 3.7 3.8 3.7 3.9 3.6 3.6 3.8 12.9 9.6 14.1 20.9 11.1 5.2 6.1 10.5 5.2 15.0 8.7 4.3 45.7 7.2 10.6 7.3 47.9 11.2 10.0 14.0 1.9 14.0 46.4 14.9 19.3 10.8 10.8 19.6 43.3 20.2 5.7 9.1 22.4 16.5 1.3 9.9 11.7 24.1 11.9 6.7 42.6 12.7 18.3 16.6 5.4 12.0 6.5 12.5 8.8 23.4 7.8 7.8 4.1 20.6 24.0 16.5 5.7 10.1 24.2 12.2 9.0 10.7 23.3 26.9 6.6 7.6 13.2 51.5 11.0 19.6 16.3 3.8 8.5 9.8 9.8 9.6 IMMP1L "FLJ25059, IMMP1" ENSG00000148950 "Inner mitochondrial membrane peptidase subunit 1" Q96LU5 11 31432401-31509645 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038372, HPA058308" Approved Enhanced Mitochondria NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 10: Non-specific - Unknown function" Mitochondria "HPA038372: AB_10669643, HPA058308: AB_2732620" "unprognostic (2.39e-1)" "unprognostic (1.20e-2)" "unprognostic (1.12e-1)" "unprognostic (6.17e-2)" "unprognostic (9.67e-2)" "unprognostic (2.08e-2)" "prognostic unfavorable (7.97e-4)" "unprognostic (7.59e-2)" "unprognostic (4.66e-3)" "unprognostic (5.15e-3)" "prognostic favorable (6.72e-4)" "unprognostic (1.97e-1)" "unprognostic (1.07e-2)" "unprognostic (4.66e-1)" "unprognostic (4.52e-2)" "unprognostic (1.37e-2)" "unprognostic (1.04e-3)" 11.7 15.6 42.8 6.4 43.7 11.1 19.3 45.5 66.4 13.5 41.8 12.7 8.6 11.5 29.8 11.7 10.4 5.1 26.2 42.8 42.3 27.2 18.6 8.9 9.5 42.4 42.0 17.5 16.4 17.9 23.3 6.9 42.3 14.3 10.0 37.7 11.8 14.1 50.0 12.5 9.5 10.7 42.9 10.8 15.1 16.7 43.0 24.8 13.2 42.1 13.1 10.9 12.6 43.5 22.9 26.9 95.6 21.0 14.9 9.9 15.3 19.9 8.7 16.2 11.7 21.0 17.5 20.7 18.7 15.9 32.5 25.8 37.6 28.8 23.8 24.9 52.6 29.4 45.5 32.3 15.8 29.6 19.9 8.0 27.1 8.7 19.2 29.5 17.5 48.8 38.0 23.2 15.9 28.2 48.5 48.9 15.8 114.6 26.3 41.1 72.2 20.6 54.6 26.2 22.5 27.0 32.5 11.6 32.5 61.9 37.1 35.1 2.6 15.3 27.2 16.2 42.2 17.2 58.2 47.5 24.9 24.9 18.5 21.9 3.0 32.2 28.9 3.4 26.3 34.1 25.3 29.5 8.1 32.1 32.0 39.8 0.8 37.3 3.0 40.2 35.4 13.6 42.8 43.7 45.5 66.4 42.8 42.3 42.4 42.0 42.3 42.9 43.0 43.5 29.2 35.3 14.6 30.7 22.4 18.2 26.8 60.5 12.0 30.6 44.6 55.1 56.8 18.6 26.8 60.7 33.3 36.3 17.6 21.7 119.3 17.0 39.8 30.2 16.9 19.4 56.5 47.4 40.6 24.5 32.5 19.7 20.9 33.8 22.7 22.7 18.2 45.0 21.3 43.7 48.0 30.6 52.9 7.7 11.4 10.5 13.4 9.4 8.8 24.4 10.3 85.3 30.9 51.3 60.7 15.8 26.7 20.7 22.0 26.0 18.6 98.4 28.9 38.5 32.9 19.1 51.0 61.6 23.0 19.6 27.3 23.7 24.2 16.2 34.7 26.2 IMMP2L "IMMP2L-IT1, IMP2" ENSG00000184903 "Inner mitochondrial membrane peptidase subunit 2" Q96T52 7 110662644-111562517 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Astrocytes: 247.8;Distal tubular cells: 160.4;Excitatory neurons: 365.4;Inhibitory neurons: 373.9;Microglial cells: 455.3;Oligodendrocyte precursor cells: 273.9;Oligodendrocytes: 233.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026711 Approved Approved Mitochondria NA NA "Cluster 24: B-cells - Unknown function" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Mitochondria "HPA026711: AB_1851760" "unprognostic (2.55e-2)" "unprognostic (1.40e-2)" "unprognostic (4.29e-1)" "unprognostic (1.04e-1)" "unprognostic (3.76e-2)" "prognostic unfavorable (1.89e-5)" "unprognostic (5.64e-3)" "unprognostic (1.00e-1)" "unprognostic (4.17e-1)" "unprognostic (5.68e-3)" "unprognostic (1.12e-1)" "unprognostic (1.09e-1)" "unprognostic (2.89e-3)" "unprognostic (1.32e-1)" "unprognostic (6.65e-2)" "unprognostic (1.79e-1)" "unprognostic (2.71e-1)" 19.2 14.2 10.4 5.1 12.5 5.2 15.7 9.6 11.7 12.4 14.2 14.6 7.6 15.3 11.9 8.0 16.0 8.5 13.1 11.9 12.2 34.0 25.7 8.1 7.5 11.3 11.3 19.5 12.1 20.1 8.0 9.0 11.3 19.0 8.2 9.2 11.1 21.1 27.3 10.2 12.9 14.2 10.9 8.4 11.8 9.9 11.4 8.9 23.5 25.1 7.5 12.5 10.5 13.1 17.5 10.3 6.1 25.1 15.8 16.0 10.7 11.8 11.9 7.7 8.1 5.1 19.8 28.4 31.4 10.2 14.3 9.6 6.6 23.6 12.7 17.9 6.7 9.7 44.2 14.0 24.2 18.2 1.1 27.9 30.7 3.3 21.4 35.0 10.2 26.2 32.0 21.4 5.9 12.3 24.4 20.3 6.0 33.2 15.8 5.1 50.0 15.0 28.0 7.3 7.0 22.1 5.1 23.8 67.3 17.2 9.6 10.4 6.5 11.8 12.3 11.9 14.4 12.2 3.5 17.4 12.9 8.4 63.1 15.9 9.1 2.9 10.5 11.9 19.4 28.5 18.3 12.3 17.0 38.7 25.0 17.6 0.5 47.0 17.3 21.3 12.4 8.1 10.4 12.5 9.6 11.7 11.9 12.2 11.3 11.3 11.3 10.9 11.4 13.1 22.3 19.2 13.2 247.8 20.4 32.9 34.4 41.4 39.9 11.3 35.3 39.4 19.5 15.7 23.9 47.8 8.4 22.4 11.9 3.1 160.4 30.1 8.4 10.4 12.6 15.3 19.3 21.9 365.4 8.1 27.1 19.5 12.8 12.0 3.8 11.3 11.7 23.8 11.7 8.4 373.9 7.0 28.5 4.9 14.1 5.6 49.4 6.1 21.4 455.3 10.1 16.3 1.0 273.9 233.7 10.8 6.8 35.0 9.2 36.2 25.5 66.8 13.3 15.6 13.1 19.5 46.7 24.2 12.8 28.0 26.6 16.3 12.6 18.7 11.7 22.1 KEL "CD238, ECE3" ENSG00000197993 "Kell metallo-endopeptidase (Kell blood group)" P23276 7 142941114-142962363 "Blood group antigen proteins, Cancer-related genes, CD markers, Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Blood group antigen, Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "bone marrow: 56.3;testis: 32.3" "Cell type enhanced" "Detected in some" "Erythroid cells: 79.7;Oligodendrocytes: 30.1;Squamous epithelial cells: 16.8" "Cancer enhanced" "Detected in some" "testis cancer: 2.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 20 "HEL: 31.7;K-562: 26.2" "Not detected" "Not detected" "Not detected" "Not detected" HPA064442 Approved "Nucleoplasm,Golgi apparatus,Plasma membrane,Cytosol" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 1: K-562 - Erythropoiesis" "Cluster 6: Erythroid cells - Oxygen transport" "Golgi apparatus, Plasma membrane" "Nucleoplasm, Cytosol" "HPA064442: " "unprognostic (5.78e-3)" "unprognostic (1.08e-5)" "unprognostic (5.29e-3)" "unprognostic (4.85e-3)" "unprognostic (9.68e-2)" "unprognostic (1.96e-2)" "unprognostic (1.03e-1)" "unprognostic (1.54e-2)" "unprognostic (5.18e-2)" "unprognostic (1.08e-2)" "unprognostic (3.71e-2)" "unprognostic (3.57e-2)" "unprognostic (2.29e-3)" "unprognostic (9.24e-2)" "unprognostic (7.05e-2)" "unprognostic (3.32e-2)" "unprognostic (3.25e-3)" 0.2 0.0 1.8 0.8 2.7 56.3 0.3 1.7 2.2 0.9 1.4 0.1 0.0 0.2 0.0 0.8 0.5 0.0 0.3 2.0 1.5 0.6 0.3 0.5 10.6 2.5 2.2 0.2 0.2 0.0 0.2 0.4 2.4 0.3 0.0 0.1 0.6 0.1 0.2 0.1 0.9 0.0 1.9 4.9 0.2 32.3 2.4 1.3 0.3 0.0 6.7 0.1 0.4 2.8 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 31.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 26.2 0.0 0.0 0.1 0.5 0.1 0.6 0.0 0.0 0.1 0.0 0.2 0.0 1.4 0.0 0.2 0.0 0.0 0.3 0.4 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 2.7 1.7 2.2 2.0 1.5 2.5 2.2 2.4 1.9 2.4 2.8 0.2 0.0 0.0 0.3 0.0 0.0 1.3 0.2 4.0 0.0 0.3 0.1 0.4 0.0 1.4 3.7 0.0 0.1 0.1 0.0 1.9 0.3 2.4 0.2 0.1 0.1 0.0 79.7 3.0 0.0 0.2 0.4 0.0 0.1 0.0 0.1 0.0 0.0 0.9 0.0 0.5 0.0 0.0 0.0 0.0 0.8 0.6 0.4 0.0 0.0 0.0 0.0 0.0 0.0 30.1 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.0 3.1 0.0 1.4 0.2 16.8 0.0 0.1 0.0 0.0 0.0 0.9 KLK1 Klk6 ENSG00000167748 "Kallikrein 1" P06870 19 50819146-50823787 "Enzymes, Metabolic proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 84 "pancreas: 9557.9;salivary gland: 5487.3" "Group enriched" "Detected in many" 7 "Exocrine glandular cells: 788.4;Intestinal goblet cells: 1317.5" "Cancer enhanced" "Detected in many" "pancreatic cancer: 50.9;renal cancer: 84.1" "Not detected" "Not detected" "Group enriched" "Detected in some" 9 "memory B-cell: 9.5;naive B-cell: 4.0" "Lineage enriched" "Detected in single" 13 "B-cells: 9.5" "Cell line enriched" "Detected in some" 4 "RPMI-8226: 43.8" HPA059690 Approved "Secreted to digestive system" NA NA 10000000 "Cluster 19: B-cells - Humoral immune response" "Cluster 25: Pancreas - Digestion" "Cluster 25: RPMI-8226 - Immune response" "Cluster 27: Mucus-secreting cells - Mucin production" "HPA059690: " "unprognostic (1.51e-3)" "unprognostic (1.23e-2)" "unprognostic (4.20e-1)" "unprognostic (1.73e-2)" "unprognostic (1.10e-1)" "unprognostic (8.72e-2)" "unprognostic (1.92e-2)" "unprognostic (7.47e-3)" "unprognostic (1.66e-1)" "unprognostic (2.49e-2)" "unprognostic (8.06e-2)" "unprognostic (2.12e-1)" "unprognostic (1.42e-2)" "unprognostic (2.55e-1)" "unprognostic (6.49e-2)" "unprognostic (2.10e-1)" "unprognostic (6.23e-2)" 1.4 2.4 0.1 4.0 0.0 0.4 1.8 0.0 0.4 1.9 0.0 68.8 9.6 2.0 0.0 1.3 0.6 0.1 3.0 0.3 0.0 89.4 0.6 0.5 0.5 0.0 0.0 4.7 9557.9 0.4 0.2 1.1 0.0 2.7 53.0 0.0 5487.3 0.1 0.2 26.3 9.7 2.8 0.0 3.3 1.4 0.1 0.0 0.2 2.9 0.2 1.5 0.2 0.9 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.7 0.4 0.2 0.3 0.5 1.6 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 1.1 0.1 0.4 0.2 0.0 0.0 0.0 0.1 1.2 0.0 0.0 0.1 0.1 0.0 0.0 9.7 0.0 0.1 0.0 43.8 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.8 0.0 0.0 0.3 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.3 0.0 9.5 0.0 0.0 0.1 4.0 0.0 0.0 0.1 0.0 0.2 0.7 0.0 0.1 0.1 0.0 0.0 0.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 18.9 19.5 1.2 2.9 1.2 0.0 1.0 1.1 0.3 0.0 2.5 0.0 0.0 0.0 0.2 62.2 45.0 3.3 0.6 0.1 1.4 0.4 117.1 0.0 0.0 788.4 0.0 7.7 1.5 0.0 8.9 8.8 0.4 0.0 0.6 0.0 0.0 1317.5 14.2 1.6 5.3 0.3 6.2 1.5 5.4 0.0 6.2 0.0 0.0 0.0 0.0 125.8 134.4 0.0 10.9 9.8 57.1 0.3 0.3 0.0 0.0 0.0 1.1 0.3 0.9 1.7 54.0 0.0 2.1 2.5 148.5 3.8 KLK10 "NES1, PRSSL1" ENSG00000129451 "Kallikrein related peptidase 10" O43240 19 51012739-51020175 "Cancer-related genes, Enzymes, Predicted secreted proteins" "Cell cycle" "Hydrolase, Protease, Serine protease" "Cancer-related genes, Tumor suppressor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "cervix: 111.8;esophagus: 412.5;vagina: 190.6" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 32.1;Basal respiratory cells: 61.4;Club cells: 113.9;Pancreatic endocrine cells: 74.8;Prostatic glandular cells: 68.6" "Cancer enhanced" "Detected in many" "head and neck cancer: 97.6" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "CAPAN-2: 67.2;HaCaT: 158.7;OE19: 68.1" "Region enriched" "Detected in single" 4 "hippocampal formation: 1.6" "Not detected" "Not detected" "Secreted in other tissues" NA NA 2500000 "Cluster 84: Esophagus - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 16: Pancreatic endocrine cells - Mixed function" "prognostic favorable (8.32e-4)" "unprognostic (6.06e-2)" "unprognostic (1.73e-1)" "unprognostic (4.26e-3)" "unprognostic (3.81e-2)" "unprognostic (1.80e-1)" "unprognostic (1.51e-2)" "unprognostic (2.10e-2)" "unprognostic (3.94e-1)" "unprognostic (3.38e-2)" "prognostic unfavorable (6.46e-5)" "unprognostic (2.71e-2)" "unprognostic (2.46e-6)" "unprognostic (9.34e-2)" "unprognostic (7.81e-2)" "unprognostic (2.66e-3)" "unprognostic (1.52e-2)" 8.6 0.6 0.7 0.2 0.4 0.6 6.2 1.2 0.4 111.8 1.0 1.5 0.3 1.7 0.2 412.5 8.6 3.5 1.3 0.3 1.4 0.6 0.3 8.7 0.0 2.6 1.7 19.7 0.6 0.2 1.5 0.2 2.8 7.2 0.6 0.3 55.2 0.5 0.2 65.7 2.6 0.6 0.7 0.2 1.8 6.0 1.0 0.3 0.6 0.1 18.8 0.6 190.6 0.4 21.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4 67.2 0.0 6.6 0.0 0.1 158.7 0.0 0.2 0.1 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.5 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 68.1 0.6 0.0 0.0 0.0 6.9 0.1 0.0 0.0 0.1 0.0 0.0 0.2 0.6 0.0 0.1 0.3 0.2 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.7 0.4 1.2 0.4 0.3 1.4 2.6 1.7 2.8 0.7 1.0 0.4 0.3 32.1 2.6 0.0 0.0 7.5 15.6 61.4 9.1 1.0 12.3 14.0 0.7 8.6 113.9 0.0 0.0 0.0 0.2 1.2 0.0 7.5 0.3 2.1 1.0 1.7 0.0 0.0 0.1 15.4 0.0 6.0 1.1 8.0 0.0 0.1 1.1 0.0 0.1 0.0 0.6 0.0 22.4 0.0 0.6 0.6 11.5 0.5 0.0 0.0 0.6 0.3 0.0 0.0 0.5 74.8 0.0 6.0 0.0 68.6 0.0 0.0 15.8 0.5 0.0 0.4 2.6 1.0 1.6 28.0 4.3 0.0 0.5 0.5 0.0 29.6 KLK11 "PRSS20, TLSP" ENSG00000167757 "Kallikrein related peptidase 11" Q9UBX7 19 51022216-51028039 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 324.2;skin 1: 239.8;vagina: 186.5" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 152.1;Club cells: 217.9;Late spermatids: 339.0;Prostatic glandular cells: 234.8;Squamous epithelial cells: 176.4;Suprabasal keratinocytes: 217.1;Urothelial cells: 186.1" "Cancer enhanced" "Detected in many" "prostate cancer: 53.3" "Region enhanced" "Detected in single" "hippocampal formation: 1.7" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "EFO-21: 13.0;HaCaT: 41.4" "Not detected" "Not detected" "Low region specificity" "Detected in all" CAB026340 Approved "Secreted in other tissues" NA NA 1800000 "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 22: Epithelial cell types - Mixed function" "CAB026340: " "unprognostic (4.23e-2)" "unprognostic (1.50e-2)" "unprognostic (1.27e-1)" "prognostic favorable (3.78e-4)" "unprognostic (2.08e-2)" "unprognostic (4.67e-1)" "unprognostic (5.32e-2)" "unprognostic (3.72e-1)" "unprognostic (3.02e-1)" "prognostic unfavorable (4.17e-4)" "unprognostic (2.92e-2)" "unprognostic (4.16e-6)" "unprognostic (3.90e-2)" "unprognostic (2.73e-1)" "unprognostic (4.40e-2)" "unprognostic (2.53e-1)" 28.4 0.2 0.0 0.4 0.0 0.0 17.1 0.9 0.1 109.8 44.5 1.9 0.7 7.2 2.6 324.2 34.2 59.3 2.0 1.7 0.0 0.3 0.8 18.9 0.0 0.2 0.1 1.6 89.1 0.0 8.8 0.0 0.3 64.9 0.6 0.7 169.5 4.2 1.9 239.8 1.4 0.3 0.0 0.1 113.3 14.4 0.6 2.5 0.4 0.3 27.2 1.4 186.5 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 6.4 0.1 13.0 0.0 0.0 41.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.5 0.1 4.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.1 1.7 0.0 0.2 0.1 0.3 0.0 0.6 0.0 0.2 86.6 10.4 0.0 0.4 106.9 152.1 131.6 13.1 0.2 33.4 35.3 0.8 88.6 217.9 0.0 0.0 0.0 0.0 0.1 0.0 9.2 111.6 4.7 1.1 3.8 20.3 0.0 0.0 130.2 0.0 9.1 91.3 15.6 1.3 0.0 0.0 0.0 0.3 0.0 0.0 10.7 118.0 0.0 11.4 339.0 2.8 1.8 8.8 0.0 0.1 0.1 0.0 0.0 0.0 79.4 0.0 0.4 0.5 234.8 0.1 0.0 26.9 1.3 0.0 0.2 7.9 2.1 2.5 176.4 217.1 0.0 1.7 0.0 0.4 186.1 KLK12 KLK-L5 ENSG00000186474 "Kallikrein related peptidase 12" Q9UKR0 19 51029092-51035230 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 13 "cervix: 108.5;esophagus: 208.6;salivary gland: 64.7;vagina: 99.4" "Cell type enhanced" "Detected in some" "Early spermatids: 30.7;Enteroendocrine cells: 40.3;Intestinal goblet cells: 24.9;Ionocytes: 14.2;Late spermatids: 34.0" "Cancer enhanced" "Detected in many" "head and neck cancer: 17.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" CAB025473 Uncertain "Secreted in other tissues" NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 17: Intestinal endocrine cells - Hormone signaling" "CAB025473: " "unprognostic (2.84e-1)" "unprognostic (1.41e-1)" "unprognostic (1.08e-3)" "unprognostic (1.15e-1)" "unprognostic (5.80e-3)" "unprognostic (4.99e-3)" "unprognostic (3.18e-1)" "unprognostic (1.41e-1)" "unprognostic (4.64e-2)" "unprognostic (1.51e-1)" "unprognostic (1.56e-1)" "prognostic favorable (8.01e-4)" "unprognostic (8.50e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 108.5 2.2 2.1 4.0 0.0 0.0 208.6 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 3.6 0.0 0.1 0.5 0.8 0.0 64.7 0.0 0.0 0.6 5.8 0.1 0.0 0.0 0.4 0.5 0.0 0.1 0.1 0.0 8.9 0.0 99.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.5 0.5 0.2 0.0 2.3 0.0 0.0 0.0 0.1 0.9 0.0 0.0 30.7 0.0 0.0 0.0 40.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 24.9 14.2 0.0 0.0 34.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.9 0.4 0.0 1.7 0.0 0.0 0.0 0.0 0.4 0.2 8.4 0.0 0.0 0.0 0.0 1.3 1.7 KLK13 KLK-L4 ENSG00000167759 "Kallikrein related peptidase 13" Q9UKR3 19 51055626-51065114 "Cancer-related genes, Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in many" 4 "esophagus: 519.9" "Group enriched" "Detected in some" 4 "Late spermatids: 246.9;Squamous epithelial cells: 68.3" "Group enriched" "Detected in many" 4 "cervical cancer: 20.6;head and neck cancer: 42.3;melanoma: 10.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 7 "HaCaT: 27.0" "Not detected" "Not detected" "Not detected" "Not detected" HPA062136 Enhanced "Secreted in other tissues" NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 31: Spermatids - Spermatogenesis" "HPA062136: AB_2684694" "unprognostic (1.99e-3)" "unprognostic (1.89e-1)" "unprognostic (1.25e-1)" "unprognostic (3.66e-2)" "unprognostic (3.43e-1)" "unprognostic (2.99e-2)" "unprognostic (1.69e-1)" "unprognostic (6.76e-2)" "unprognostic (2.18e-2)" "unprognostic (8.30e-2)" "unprognostic (7.07e-6)" "unprognostic (7.33e-2)" "unprognostic (2.53e-1)" "unprognostic (6.38e-2)" "unprognostic (7.06e-2)" 0.2 0.2 0.1 0.2 0.1 0.0 1.6 0.1 0.2 96.3 0.9 0.6 1.6 0.5 0.4 519.9 0.5 1.1 0.2 0.1 0.1 0.1 0.2 0.7 0.0 0.2 0.5 0.2 4.4 0.4 0.3 0.0 0.1 0.6 0.1 0.0 74.9 0.0 0.1 10.8 0.8 0.3 0.1 0.1 1.4 4.3 0.1 0.2 0.3 0.0 63.5 0.2 122.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 2.4 0.0 0.0 27.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.1 3.7 0.0 0.0 0.0 0.0 0.0 0.7 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.3 1.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.2 0.1 0.1 0.2 0.5 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 2.0 0.6 1.1 4.0 0.0 0.9 1.9 0.4 0.0 8.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 37.4 0.1 0.1 0.3 1.8 0.0 0.0 1.3 0.0 0.3 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 4.1 0.0 0.3 246.9 0.3 0.1 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.4 0.0 0.7 0.0 0.0 0.2 0.0 0.0 0.0 0.2 1.0 0.7 68.3 1.3 0.0 0.4 0.4 0.0 2.1 KLK14 KLK-L6 ENSG00000129437 "Kallikrein related peptidase 14" Q9P0G3 19 51077495-51084245 "Cancer-related genes, Enzymes, Plasma proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "skin 1: 9.7" "Cell type enhanced" "Detected in single" "Club cells: 2.5" "Cancer enhanced" "Detected in many" "head and neck cancer: 26.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HaCaT: 10.7;HEK 293: 2.9;U-266/84: 5.5" "Not detected" "Not detected" "Not detected" "Not detected" CAB026228 Uncertain "Secreted in other tissues" NA NA "Cluster 27: Brain & Skin - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 49: Ciliated cells - Cilium organization" "CAB026228: " "unprognostic (2.08e-1)" "unprognostic (1.22e-1)" "unprognostic (2.44e-2)" "unprognostic (2.60e-2)" "unprognostic (1.23e-1)" "unprognostic (6.12e-2)" "unprognostic (4.91e-2)" "unprognostic (5.79e-2)" "unprognostic (7.84e-2)" "unprognostic (1.38e-1)" "unprognostic (7.60e-2)" "unprognostic (8.87e-2)" "unprognostic (2.04e-8)" "unprognostic (1.93e-1)" "unprognostic (3.74e-3)" "unprognostic (1.94e-2)" "unprognostic (8.08e-2)" 0.5 0.3 2.1 0.2 2.2 0.1 1.6 2.3 3.3 4.2 1.9 0.4 1.3 0.5 0.6 0.9 0.7 0.3 0.8 2.2 1.7 0.5 0.3 0.4 0.3 2.1 1.9 1.1 0.7 0.0 0.6 0.0 2.2 0.8 0.3 0.6 0.8 0.5 0.3 9.7 0.7 0.1 1.6 0.6 0.6 0.9 2.0 0.3 0.4 0.1 0.5 0.6 3.9 2.3 1.4 0.5 0.1 0.6 0.4 0.4 0.6 0.1 0.0 0.0 0.1 1.2 1.4 0.6 0.4 0.2 0.3 10.7 0.1 0.2 0.0 0.3 2.9 0.2 0.9 0.0 0.1 0.2 0.2 0.2 0.3 0.4 0.4 0.1 0.1 0.4 0.2 0.3 0.0 0.9 0.2 0.5 0.6 1.2 1.1 0.1 0.1 0.6 0.0 0.6 0.1 0.0 0.2 1.0 0.3 0.2 0.4 0.0 0.0 0.1 0.4 0.6 0.2 2.6 5.5 0.3 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 2.2 2.3 3.3 2.2 1.7 2.1 1.9 2.2 1.6 2.0 2.3 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.2 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 KLK15 "ACO, HSRNASPH, prostinogen" ENSG00000174562 "Kallikrein related peptidase 15" Q9H2R5 19 50825289-50837213 "Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 3.2;salivary gland: 5.6" "Cell type enhanced" "Detected in some" "Early spermatids: 5.5;Intestinal goblet cells: 34.6;Late spermatids: 8.8;Spermatocytes: 15.0;Spermatogonia: 9.5" "Group enriched" "Detected in some" 4 "prostate cancer: 3.5;renal cancer: 1.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 5 "RPMI-8226: 2.4" "Not detected" "Not detected" "Not detected" "Not detected" HPA019802 Uncertain "Secreted to blood" NA NA "Cluster 24: Salivary gland - Salivary secretion" "Cluster 25: RPMI-8226 - Immune response" "Cluster 27: Mucus-secreting cells - Mucin production" "HPA019802: AB_1852601" "unprognostic (6.06e-2)" "unprognostic (2.85e-1)" "unprognostic (8.13e-2)" "unprognostic (2.90e-1)" "unprognostic (2.29e-2)" "unprognostic (1.16e-1)" "unprognostic (1.17e-1)" "unprognostic (1.55e-1)" "unprognostic (2.52e-1)" "unprognostic (2.72e-2)" 0.0 1.3 0.0 0.2 0.0 0.0 0.0 0.1 0.2 0.0 0.0 3.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.5 1.2 0.0 5.6 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 1.2 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 5.5 0.0 0.0 0.1 1.8 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 34.6 0.0 0.0 0.0 8.8 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.0 9.5 0.0 0.0 0.0 0.0 0.0 0.8 0.0 KLK2 ENSG00000167751 "Kallikrein related peptidase 2" P20151 19 50861568-50880567 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 87 "prostate: 566.2" "Cell type enriched" "Detected in some" 40 "Prostatic glandular cells: 777.2" "Cancer enriched" "Detected in some" 1666 "prostate cancer: 989.9" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "BEWO: 3.5;NB-4: 5.6" HPA000764 Supported "Secreted in male reproductive system" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 51: Non-specific - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 35: Glandular cells - Unknown function" "HPA000764: AB_1079700" "unprognostic (3.05e-2)" "unprognostic (2.40e-1)" "unprognostic (1.69e-1)" "unprognostic (8.53e-2)" "unprognostic (1.15e-1)" "unprognostic (8.97e-2)" "unprognostic (3.22e-1)" "unprognostic (6.44e-2)" "unprognostic (8.06e-2)" "unprognostic (3.61e-1)" "unprognostic (2.11e-3)" "unprognostic (7.56e-2)" "unprognostic (8.10e-2)" "unprognostic (1.68e-1)" "unprognostic (2.04e-1)" 0.7 1.1 3.2 1.2 2.3 6.4 0.5 5.2 4.3 0.2 2.2 0.4 1.5 0.6 1.1 0.5 0.3 0.2 0.3 2.6 2.2 0.4 0.8 0.5 1.0 2.2 3.1 0.4 0.0 0.8 0.0 0.2 2.9 566.2 0.3 1.7 1.9 0.4 1.0 0.8 1.0 0.1 0.6 0.7 0.5 3.0 2.4 0.0 1.9 0.0 0.2 0.2 0.0 6.3 0.9 0.6 0.3 0.7 0.0 0.4 3.5 0.2 0.1 0.1 0.1 0.3 0.4 1.0 0.1 0.0 0.3 0.9 0.1 0.0 0.1 0.9 0.6 0.0 0.7 0.0 0.0 0.1 1.7 0.2 0.1 0.1 0.2 0.2 0.0 0.6 0.7 0.9 0.2 1.0 0.6 5.6 0.5 0.9 0.0 0.4 0.0 1.6 0.0 1.1 0.5 0.5 0.1 0.7 0.6 0.1 0.5 0.2 0.4 0.6 1.0 2.6 0.9 0.8 1.8 0.4 1.0 0.6 0.7 0.4 0.6 0.5 0.3 0.3 0.2 0.3 0.2 0.3 0.1 0.6 0.2 0.4 1.7 0.4 0.2 0.5 0.1 0.2 3.2 2.3 5.2 4.3 2.6 2.2 2.2 3.1 2.9 0.6 2.4 6.3 0.0 0.0 0.6 0.0 0.2 0.3 10.2 0.0 0.0 0.0 16.1 2.8 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.8 1.5 0.0 0.0 0.0 0.0 0.2 1.1 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 5.2 0.0 4.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 777.2 0.0 0.1 0.0 0.0 0.0 0.0 1.8 19.3 7.2 0.0 0.9 0.0 0.6 1.7 0.0 12.0 KLK3 "APS, PSA" ENSG00000142515 "Kallikrein related peptidase 3" P07288 19 50854915-50860764 "Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 320 "prostate: 8011.8" "Cell type enriched" "Detected in some" 77 "Prostatic glandular cells: 3438.6" "Cancer enriched" "Detected in some" 3905 "prostate cancer: 4241.6" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 173 "BEWO: 31.7;NB-4: 27.8;RPMI-8226: 19.3;SH-SY5Y: 10.5;U-2197: 10.7" "CAB000070, HPA000764" Enhanced "Secreted in male reproductive system" NA NA 7000000 "Cluster 51: Non-specific - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 35: Glandular cells - Unknown function" "CAB000070: , HPA000764: AB_1079700" "unprognostic (5.06e-3)" "unprognostic (5.60e-2)" "unprognostic (9.93e-2)" "unprognostic (3.90e-2)" "unprognostic (1.09e-2)" "unprognostic (1.26e-2)" "unprognostic (1.88e-2)" "unprognostic (1.54e-1)" "unprognostic (5.13e-3)" "unprognostic (1.94e-1)" "unprognostic (4.64e-1)" "unprognostic (3.15e-1)" 4.3 7.6 0.0 5.6 0.0 0.0 9.0 0.0 0.0 0.5 0.0 2.6 4.8 1.6 14.4 0.2 4.0 0.0 0.5 0.0 0.0 1.4 1.5 1.2 1.7 0.0 0.0 0.3 0.9 0.6 0.2 0.3 0.0 8011.8 1.1 0.0 4.5 25.0 0.3 0.5 3.7 0.0 0.0 0.2 1.0 6.9 0.0 0.0 0.8 0.0 0.0 0.5 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 31.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 27.8 0.0 0.0 0.0 0.0 0.0 19.3 0.1 0.0 0.0 10.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.7 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 39.0 0.0 0.0 0.0 12.4 1.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 1.0 0.0 0.4 2.6 0.0 0.0 0.2 0.0 0.0 3.4 0.0 0.0 0.0 12.9 0.0 0.0 0.0 0.0 0.1 9.0 0.0 0.0 0.0 1.8 0.0 11.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 3438.6 0.1 0.1 0.0 0.0 0.0 0.0 6.9 0.1 0.0 0.0 0.0 0.0 4.2 0.2 0.4 44.6 KLK4 "EMSP, EMSP1, KLK-L1, PRSS17, PSTS" ENSG00000167749 "Kallikrein related peptidase 4" Q9Y5K2 19 50906352-50910738 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" Biomineralization "Hydrolase, Protease, Serine protease" "Amelogenesis imperfecta, Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 32 "prostate: 286.4" "Cell type enriched" "Detected in some" 15 "Prostatic glandular cells: 106.1" "Cancer enriched" "Detected in many" 55 "prostate cancer: 463.7" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CAPAN-2: 6.4;HaCaT: 7.9;OE19: 7.3;SK-BR-3: 5.1" "Not detected" "Not detected" "Region enhanced" "Detected in some" "spinal cord: 4.5" HPA051839 Enhanced "Secreted in male reproductive system" NA NA "Cluster 51: Non-specific - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 35: Glandular cells - Unknown function" "HPA051839: AB_2681632" "unprognostic (3.58e-2)" "unprognostic (2.26e-1)" "unprognostic (1.23e-3)" "unprognostic (1.66e-3)" "unprognostic (3.11e-2)" "unprognostic (4.35e-1)" "unprognostic (3.18e-1)" "unprognostic (6.66e-2)" "unprognostic (9.69e-2)" "unprognostic (8.23e-3)" "unprognostic (1.26e-1)" "unprognostic (1.07e-1)" "unprognostic (4.20e-3)" "unprognostic (3.27e-3)" "unprognostic (2.21e-2)" "unprognostic (1.64e-2)" "unprognostic (1.34e-1)" 0.4 2.9 0.4 1.5 0.3 1.1 1.7 1.7 1.2 6.5 0.0 3.0 7.3 4.4 1.1 2.1 0.6 1.0 0.1 0.3 0.8 0.6 1.2 0.3 0.8 1.6 0.8 0.1 0.9 1.0 0.0 0.3 1.6 286.4 3.6 0.5 4.8 2.7 3.5 8.9 5.1 0.3 0.5 0.3 1.9 1.2 0.6 0.1 3.8 1.3 0.8 1.2 0.2 0.5 4.1 1.6 0.2 0.2 0.0 0.0 3.5 0.0 0.0 0.0 0.0 3.5 6.4 0.4 0.3 0.1 0.2 7.9 0.0 4.2 0.0 1.1 1.1 1.3 3.8 1.4 0.0 1.4 1.7 0.0 1.9 0.0 0.0 0.2 0.0 0.3 0.7 3.3 0.0 1.0 0.1 2.0 0.1 7.3 0.3 0.3 0.4 0.9 0.0 2.6 0.0 0.4 0.3 5.1 0.0 0.2 4.0 0.3 0.9 0.2 0.2 1.0 0.2 2.0 0.9 0.4 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.3 1.7 1.2 0.3 0.8 1.6 0.8 1.6 0.5 0.6 0.5 0.1 0.0 0.0 0.0 0.0 0.3 3.6 0.0 0.0 0.6 0.5 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.6 0.0 2.6 0.1 0.0 0.0 0.1 0.2 0.0 1.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 6.7 0.0 0.0 0.0 0.4 0.9 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.7 0.0 106.1 0.2 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.3 0.0 0.6 0.0 0.0 3.3 1.0 2.6 KLK5 "KLK-L2, SCTE" ENSG00000167754 "Kallikrein related peptidase 5" Q9Y337 19 50943303-50953093 "Cancer-related genes, Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "skin 1: 202.7" "Group enriched" "Detected in some" 4 "Early spermatids: 85.4;Late spermatids: 193.2" "Group enriched" "Detected in many" 5 "head and neck cancer: 73.1;melanoma: 32.1;ovarian cancer: 112.2" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 41 "A-431: 485.1;HaCaT: 455.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA014343, CAB025503, CAB026341, HPA073512" Enhanced "Secreted in other tissues" NA NA 2500000 "Cluster 61: Skin - Cornification" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 25: Spermatids - Spermatogenesis" "CAB025503: , CAB026341: , HPA014343: AB_1852603, HPA073512: " "unprognostic (3.19e-2)" "unprognostic (1.06e-1)" "prognostic unfavorable (2.33e-4)" "unprognostic (4.30e-4)" "unprognostic (3.01e-1)" "prognostic unfavorable (9.79e-4)" "unprognostic (3.04e-1)" "unprognostic (3.05e-1)" "unprognostic (1.70e-3)" "unprognostic (2.21e-1)" "unprognostic (2.76e-1)" "unprognostic (2.53e-1)" "unprognostic (9.16e-3)" "prognostic unfavorable (3.85e-6)" 4.6 0.0 1.1 0.0 1.1 0.0 30.2 0.4 2.6 15.6 0.6 0.0 0.1 0.1 0.0 23.0 0.5 0.0 0.2 1.1 0.8 0.5 0.1 6.1 0.0 1.0 1.0 0.0 0.0 0.0 0.1 0.0 1.0 0.2 0.0 0.0 23.6 0.0 1.1 202.7 0.0 0.0 0.5 0.3 0.0 14.2 1.6 0.1 0.1 0.0 0.6 0.0 13.5 0.7 485.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.4 0.0 0.0 0.0 0.1 455.4 0.0 1.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 1.1 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.4 0.1 0.0 0.0 0.0 0.8 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 1.3 0.0 0.0 1.1 0.0 1.5 0.1 0.4 0.3 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 1.1 0.4 2.6 1.1 0.8 1.0 1.0 1.0 0.5 1.6 0.7 0.2 16.0 0.0 0.0 0.0 26.8 1.8 2.4 12.0 0.0 33.0 27.2 0.3 0.0 0.8 0.0 0.0 0.0 1.0 0.0 0.0 0.0 85.4 0.0 0.0 0.8 0.0 0.0 0.5 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.7 193.2 1.2 0.2 1.8 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.4 0.0 1.1 0.0 0.0 0.5 0.0 0.0 0.0 0.1 1.6 0.8 2.8 10.9 0.0 0.3 0.0 0.0 0.1 KLK6 "Bssp, Klk7, neurosin, PRSS18, PRSS9" ENSG00000167755 "Kallikrein related peptidase 6" Q92876 19 50958631-50969673 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 253.0;esophagus: 94.2" "Cell type enhanced" "Detected in some" "Breast glandular cells: 23.9;Breast myoepithelial cells: 16.1;Collecting duct cells: 11.0;Oligodendrocytes: 87.9" "Cancer enhanced" "Detected in many" "ovarian cancer: 131.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "A-431: 575.5;CAPAN-2: 1346.5" "Region enhanced" "Detected in all" "pons and medulla: 167.8" "Region enhanced" "Detected in many" "spinal cord: 371.7" HPA051837 Supported "Nucleoplasm,Nuclear membrane,Cytokinetic bridge" "Secreted in other tissues" Yes No 10000000 "Cluster 70: Brain - Nervous system development" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 30: Mammary glandular cells - Lactation" Nucleoplasm "Nuclear membrane, Cytokinetic bridge" "HPA051837: " "unprognostic (7.30e-2)" "unprognostic (3.32e-1)" "unprognostic (6.58e-2)" "prognostic unfavorable (1.38e-5)" "unprognostic (1.10e-1)" "unprognostic (2.31e-1)" "prognostic unfavorable (8.85e-4)" "unprognostic (3.02e-1)" "unprognostic (2.46e-1)" "prognostic unfavorable (7.82e-4)" "unprognostic (4.45e-1)" "unprognostic (2.72e-2)" "unprognostic (1.31e-1)" "unprognostic (2.46e-1)" "unprognostic (9.07e-2)" "prognostic unfavorable (1.27e-4)" 0.2 0.0 71.8 0.0 135.8 0.0 7.2 170.8 119.8 53.1 45.6 0.1 0.2 1.5 0.4 94.2 28.9 3.5 0.0 72.9 94.3 20.4 0.0 0.0 0.0 213.8 130.8 0.8 0.0 0.0 0.7 0.0 182.1 0.1 0.0 0.0 15.8 2.2 0.0 9.9 0.0 0.0 123.6 5.8 0.1 0.9 118.1 1.5 0.0 0.0 36.4 0.0 27.4 253.0 575.5 0.0 0.0 1.4 0.0 0.0 2.2 0.0 0.0 0.0 0.0 67.7 1346.5 0.0 8.1 0.0 0.6 8.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 1.1 131.0 2.2 0.1 0.0 0.0 16.2 0.0 0.0 0.0 0.0 0.0 5.6 18.2 1.0 1.9 0.0 1.1 46.3 0.0 1.3 0.0 0.4 0.3 0.0 0.2 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 71.8 135.8 170.8 119.8 72.9 94.3 213.8 130.8 182.1 123.6 118.1 253.0 0.2 0.0 0.0 0.0 0.2 0.0 1.0 0.5 0.0 0.0 23.9 16.1 0.3 0.0 1.7 11.0 0.0 0.1 0.4 0.0 0.0 0.1 2.3 0.6 7.5 0.4 0.0 0.0 0.2 0.2 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 3.7 0.3 0.1 0.0 1.0 0.0 0.0 0.0 0.5 87.9 7.8 0.0 0.0 0.0 0.6 0.0 0.0 1.0 0.0 0.0 0.0 0.1 0.9 0.3 1.6 0.0 0.3 0.1 0.0 0.0 2.4 KLK7 "PRSS6, SCCE" ENSG00000169035 "Kallikrein related peptidase 7" P49862 19 50976468-50984099 "Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "esophagus: 94.7;skin 1: 201.2" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 6.4;Basal keratinocytes: 5.0;Basal squamous epithelial cells: 4.6;Breast glandular cells: 9.4;Breast myoepithelial cells: 10.4;Squamous epithelial cells: 5.9;Suprabasal keratinocytes: 10.7" "Cancer enhanced" "Detected in many" "ovarian cancer: 139.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 5.0;CAPAN-2: 8.0;HaCaT: 31.7" "Not detected" "Not detected" "Not detected" "Not detected" "HPA018994, CAB026342, HPA062126" Enhanced Supported "Nuclear membrane,Plasma membrane" "Secreted in other tissues" NA NA 3700000 "Cluster 11: Basophils - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 16: Pancreatic endocrine cells - Mixed function" "Plasma membrane" "Nuclear membrane" "CAB026342: , HPA018994: AB_1852607, HPA062126: AB_2684691" "unprognostic (1.88e-2)" "unprognostic (6.41e-2)" "unprognostic (8.57e-2)" "prognostic unfavorable (8.06e-5)" "unprognostic (4.33e-3)" "unprognostic (2.28e-1)" "unprognostic (4.44e-3)" "unprognostic (2.99e-1)" "unprognostic (1.31e-1)" "prognostic unfavorable (1.16e-4)" "unprognostic (2.10e-1)" "unprognostic (2.82e-3)" "unprognostic (3.25e-1)" "unprognostic (4.47e-2)" "unprognostic (1.12e-2)" "unprognostic (5.60e-3)" 7.1 0.1 8.4 0.1 9.2 0.3 11.2 0.9 7.4 19.7 1.0 0.1 0.5 0.7 0.2 94.7 16.3 1.3 0.2 6.5 1.4 12.1 0.1 3.1 0.0 4.3 1.4 0.1 0.1 0.3 0.7 0.0 4.9 0.1 0.0 0.1 21.6 0.2 1.0 201.2 0.0 0.2 2.1 0.8 0.3 0.3 7.4 0.9 0.2 0.0 10.9 0.0 30.9 3.0 5.0 0.0 0.0 0.2 0.0 0.0 1.5 0.0 0.0 0.0 0.0 1.8 8.0 0.0 1.1 0.0 0.1 31.7 0.0 1.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.2 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.1 0.1 0.3 0.5 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.1 0.0 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 8.4 9.2 0.9 7.4 6.5 1.4 4.3 1.4 4.9 2.1 7.4 3.0 0.0 6.4 1.1 0.0 0.0 5.0 0.1 0.5 4.6 0.0 9.4 10.4 0.2 0.0 2.4 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 2.6 0.2 0.0 0.0 1.7 0.0 0.0 2.9 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.3 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.0 0.0 0.0 1.0 0.0 0.0 0.8 0.0 0.0 0.0 0.1 0.0 0.2 5.9 10.7 0.0 0.1 0.0 0.1 2.7 KLK8 "HNP, neuropsin, ovasin, PRSS19, TADG14" ENSG00000129455 "Kallikrein related peptidase 8" O60259 19 50996007-51002711 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "esophagus: 118.0;skin 1: 87.1;vagina: 47.2" "Group enriched" "Detected in some" 5 "Basal keratinocytes: 66.0;Suprabasal keratinocytes: 180.1" "Cancer enhanced" "Detected in many" "head and neck cancer: 29.9;ovarian cancer: 30.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "A-431: 88.3;CAPAN-2: 112.2;HaCaT: 83.5" "Region enriched" "Detected in all" 5 "hippocampal formation: 36.1" "Region enhanced" "Detected in single" "basal ganglia: 1.2" "CAB019393, HPA035761" Enhanced Approved Vesicles "Secreted in other tissues" NA NA 3200000 "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 28: Keratinocytes - Keratinization" Vesicles "CAB019393: , HPA035761: AB_2674769" "unprognostic (4.27e-3)" "unprognostic (2.59e-1)" "unprognostic (2.54e-1)" "prognostic unfavorable (2.31e-4)" "unprognostic (5.46e-2)" "prognostic unfavorable (5.72e-4)" "unprognostic (2.95e-1)" "unprognostic (9.02e-2)" "prognostic unfavorable (1.10e-4)" "unprognostic (4.29e-2)" "unprognostic (4.66e-2)" "unprognostic (1.54e-1)" "prognostic unfavorable (6.17e-4)" 5.7 0.0 0.1 0.0 0.0 0.0 8.4 0.8 0.7 24.7 0.2 0.0 0.0 0.9 0.4 118.0 13.2 0.1 0.2 0.0 0.0 0.4 0.1 0.1 0.0 0.7 0.2 0.1 0.0 0.0 0.6 0.0 0.4 0.0 0.0 0.0 17.1 0.1 0.7 87.1 0.0 0.1 0.0 0.2 0.1 1.2 0.2 1.1 0.5 0.0 9.6 0.0 47.2 0.5 88.3 0.0 0.0 0.6 0.0 0.0 12.3 0.0 0.0 0.0 0.0 1.7 112.2 0.0 2.2 0.0 0.1 83.5 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.7 10.3 0.0 0.0 0.0 0.0 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.9 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.8 0.7 0.0 0.0 0.7 0.2 0.4 0.0 0.2 0.5 0.1 0.0 0.0 0.0 0.3 66.0 0.0 0.4 14.8 0.0 13.0 15.6 0.1 0.0 1.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.8 0.7 11.0 0.3 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.7 5.0 1.8 0.1 8.8 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 2.2 0.0 0.0 0.0 0.3 2.8 6.2 21.1 180.1 0.0 0.2 0.0 0.2 0.1 KLK9 KLK-L3 ENSG00000213022 "Kallikrein related peptidase 9" Q9UKQ9 19 51002508-51009634 "Cancer-related genes, Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "skin 1: 11.8" "Not detected" "Not detected" "Cancer enriched" "Detected in single" 6 "head and neck cancer: 0.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "HaCaT: 1.0" CAB025049 Enhanced "Secreted in other tissues" NA NA "Cluster 61: Skin - Cornification" "Cluster 42: Epithelial cell lines - Epithelial cell function" "CAB025049: " "unprognostic (3.22e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 11.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.6 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 KLKB1 KLK3 ENSG00000164344 "Kallikrein B1" P03952 4 186208979-186258471 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Blood coagulation, Fibrinolysis, Hemostasis, Inflammatory response" "Hydrolase, Protease, Serine protease" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 25 "liver: 328.4" "Cell type enriched" "Detected in many" 5 "Hepatocytes: 280.5" "Cancer enriched" "Detected in some" 17 "liver cancer: 27.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "NTERA-2: 3.1;SCLC-21H: 2.1;U-937: 1.3" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Secreted to blood" NA NA 28900000000 5300000000 "Cluster 62: Liver - Hemostasis" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 2: Hepatocytes - Metabolism" "unprognostic (4.80e-2)" "unprognostic (4.53e-3)" "unprognostic (4.36e-2)" "unprognostic (4.17e-2)" "unprognostic (5.93e-2)" "unprognostic (1.90e-2)" "unprognostic (1.15e-2)" "unprognostic (2.83e-1)" "unprognostic (8.14e-2)" "unprognostic (1.35e-1)" "unprognostic (1.38e-2)" "unprognostic (1.15e-1)" "unprognostic (1.45e-2)" "unprognostic (6.01e-2)" "unprognostic (7.30e-2)" "unprognostic (1.20e-1)" "unprognostic (1.59e-2)" 0.6 1.8 5.9 0.3 6.5 0.0 0.6 6.0 7.6 1.4 9.3 2.3 2.8 0.6 1.0 0.4 1.3 2.5 2.6 6.3 6.2 7.7 328.4 1.0 0.7 7.0 6.5 0.7 4.8 1.0 3.6 0.2 6.4 1.7 1.4 13.1 0.7 0.6 2.4 0.3 2.6 0.6 6.1 2.4 0.8 2.0 6.0 0.4 1.9 1.8 0.4 1.5 0.9 6.3 0.0 0.0 0.0 0.0 0.1 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.2 0.0 3.1 0.0 0.0 0.0 0.0 0.0 0.5 0.0 2.1 0.1 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.9 6.5 6.0 7.6 6.3 6.2 7.0 6.5 6.4 6.1 6.0 6.3 0.1 0.0 0.0 48.3 0.7 0.0 0.1 0.2 0.6 5.1 0.3 0.5 4.3 14.3 0.1 1.8 16.7 0.0 0.5 0.6 0.0 1.8 2.8 0.6 0.2 1.0 3.0 2.7 10.2 0.5 0.0 0.4 0.0 0.4 0.0 0.2 5.7 280.5 0.2 0.0 15.6 0.4 0.0 4.4 0.0 2.2 0.6 0.3 0.0 6.5 0.1 10.6 2.1 8.0 7.7 0.4 1.4 0.0 0.1 0.0 2.6 1.6 1.1 5.1 0.0 0.6 0.3 1.3 1.3 0.1 0.0 0.0 0.6 0.1 0.7 0.1 LACTB "FLJ14902, MRPL56" ENSG00000103642 "Lactamase beta" P83111 15 63121833-63142061 "Enzymes, Predicted intracellular proteins" "Lipid metabolism" "Hydrolase, Protease" "Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "monocytes: 152.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036361, HPA036362" Supported Supported Mitochondria "Intracellular and membrane" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 3: Monocytes - Immune response regulation" Mitochondria "HPA036361: AB_10672244, HPA036362: AB_10670798" "unprognostic (6.07e-2)" "unprognostic (2.02e-1)" "unprognostic (2.22e-2)" "unprognostic (2.87e-1)" "unprognostic (1.20e-2)" "unprognostic (3.10e-2)" "unprognostic (8.08e-2)" "unprognostic (6.25e-2)" "unprognostic (8.98e-2)" "unprognostic (3.08e-1)" "unprognostic (6.22e-3)" "unprognostic (5.16e-3)" "unprognostic (6.28e-2)" "unprognostic (3.24e-1)" "unprognostic (8.64e-2)" "unprognostic (7.90e-2)" "unprognostic (3.88e-3)" 17.3 25.4 7.1 21.2 7.4 57.0 12.5 7.2 8.0 8.4 10.8 18.5 19.6 7.6 8.4 14.9 7.0 14.3 22.2 7.2 7.3 23.6 42.4 19.0 19.8 7.3 7.5 8.1 10.6 9.9 6.7 11.8 7.4 9.2 15.9 4.7 9.9 6.8 49.2 12.0 16.9 9.0 7.2 18.3 12.8 22.1 8.3 9.1 9.3 36.3 13.2 19.7 9.2 8.4 60.3 37.0 10.4 7.3 51.9 27.4 8.7 25.7 39.4 43.3 79.9 9.3 37.5 8.0 31.0 37.5 46.9 16.6 35.6 16.7 54.2 55.1 8.9 15.6 12.2 23.7 48.0 14.2 26.1 37.3 35.1 44.5 36.4 64.9 45.2 46.4 14.9 22.1 74.7 22.6 10.9 17.3 15.6 36.7 11.7 8.0 26.6 18.5 23.6 92.5 9.3 4.4 18.6 20.7 59.0 36.0 15.9 23.4 81.5 57.8 44.8 26.2 32.9 23.3 21.8 2.2 44.3 39.2 27.3 4.4 8.4 4.4 1.1 8.3 1.8 3.1 0.9 0.9 9.8 2.6 0.8 1.4 5.3 2.1 7.3 0.8 3.0 2.2 7.1 7.4 7.2 8.0 7.2 7.3 7.3 7.5 7.4 7.2 8.3 8.4 24.6 25.6 22.6 4.9 25.7 58.2 27.2 12.0 19.9 6.5 21.7 16.1 42.5 22.8 10.9 12.9 12.5 15.8 19.3 26.0 25.4 56.0 62.9 13.2 16.4 31.1 7.3 10.8 12.5 43.1 40.5 26.4 17.3 19.3 66.5 12.1 8.9 57.0 88.6 8.4 14.5 27.1 16.2 71.3 72.5 30.6 14.3 97.0 26.6 15.9 152.9 6.9 7.2 10.1 8.1 75.0 19.0 16.1 21.3 35.6 25.2 79.2 9.2 11.3 6.6 37.9 31.5 122.9 25.6 26.3 60.0 18.1 21.8 23.9 20.4 39.6 LAP3 "LAP, LAPEP, PEPS" ENSG00000002549 "Leucine aminopeptidase 3" P28838 4 17577198-17607972 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Adipocytes: 230.6;Hofbauer cells: 262.1;Proximal tubular cells: 274.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029606, HPA029607" Enhanced Supported Nucleoplasm,Midbody,Cytosol Yes No 3500000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 64: Macrophages - Immune response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Cytosol "Nucleoplasm, Midbody" "HPA029606: AB_10599288, HPA029607: AB_10611381" "unprognostic (2.10e-2)" "unprognostic (1.01e-1)" "unprognostic (6.95e-3)" "unprognostic (1.46e-1)" "unprognostic (1.26e-1)" "unprognostic (2.87e-1)" "unprognostic (2.16e-1)" "unprognostic (1.55e-1)" "unprognostic (5.33e-2)" "unprognostic (1.44e-3)" "unprognostic (2.61e-3)" "unprognostic (1.17e-1)" "unprognostic (4.29e-3)" "unprognostic (1.73e-1)" "unprognostic (3.28e-2)" "unprognostic (3.06e-1)" "unprognostic (8.79e-2)" 92.8 52.6 33.0 131.4 34.8 59.2 60.3 39.0 42.9 30.7 31.4 60.3 78.3 34.4 25.4 44.6 45.4 67.3 65.0 31.8 36.3 106.3 190.4 100.6 150.4 46.3 37.7 24.0 30.9 61.0 22.1 70.9 42.2 36.7 62.0 20.0 67.7 31.0 68.1 40.3 61.3 76.2 45.6 94.1 55.3 43.8 41.9 56.8 46.4 63.8 94.3 82.8 25.3 42.9 51.7 44.4 41.6 39.4 80.5 97.9 0.4 79.6 89.1 282.3 340.3 81.4 96.1 202.0 51.7 61.6 167.9 31.3 157.7 56.3 106.7 77.7 45.2 112.1 47.3 107.6 94.1 102.3 69.2 100.0 35.3 92.7 48.6 32.3 99.7 52.2 110.6 139.9 67.6 55.6 91.9 139.5 87.1 96.3 83.9 139.8 39.8 102.7 73.5 59.6 61.4 50.2 72.9 44.4 161.1 57.3 37.9 39.1 65.2 71.3 48.5 76.1 140.6 127.7 208.8 172.7 96.3 167.2 70.8 43.1 200.6 44.7 33.7 210.0 31.0 32.7 31.2 36.3 204.6 23.5 26.7 28.3 28.1 54.0 158.1 116.6 60.2 135.8 33.0 34.8 39.0 42.9 31.8 36.3 46.3 37.7 42.2 45.6 41.9 42.9 230.6 28.9 49.6 10.7 34.4 22.0 26.1 60.1 21.6 8.1 53.5 41.7 48.9 18.6 44.1 27.6 2.1 35.9 68.3 44.2 117.4 68.6 100.5 67.3 45.7 129.7 16.3 31.7 6.4 109.2 54.7 42.0 29.6 40.7 64.1 29.4 71.0 95.5 262.1 6.7 9.6 35.6 42.7 92.1 50.5 31.7 23.0 141.9 42.7 18.7 195.0 103.8 28.8 9.5 21.2 53.3 31.8 35.0 71.2 26.9 52.4 274.0 92.5 15.4 32.9 31.3 57.8 95.7 13.7 32.5 22.9 55.7 42.4 80.7 45.6 27.1 LGMN "LGMN1, PRSC1" ENSG00000100600 Legumain Q99538 14 92703807-92748679 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hofbauer cells: 1448.9;Macrophages: 346.1;Syncytiotrophoblasts: 416.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 11 "plasmacytoid DC: 209.2" "Lineage enriched" "Detected in all" 12 "dendritic cells: 209.2" "Cell line enhanced" "Detected in many" "RPMI-8226: 898.6;U-266/70: 462.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001426 Enhanced Approved Nucleoplasm,Vesicles "Intracellular and membrane" NA NA 2000000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 1: Thyroid gland - Transcription" "Cluster 25: RPMI-8226 - Immune response" "Cluster 4: Macrophages - Innate immune response" Vesicles Nucleoplasm "HPA001426: AB_1079247" "unprognostic (1.19e-1)" "unprognostic (1.16e-1)" "unprognostic (2.37e-1)" "unprognostic (1.52e-1)" "unprognostic (1.99e-1)" "unprognostic (3.29e-2)" "unprognostic (4.52e-2)" "unprognostic (1.31e-1)" "unprognostic (5.03e-2)" "unprognostic (3.50e-2)" "unprognostic (4.70e-2)" "unprognostic (2.47e-1)" "prognostic favorable (4.70e-4)" "unprognostic (8.06e-2)" "unprognostic (3.64e-2)" "unprognostic (7.18e-3)" "unprognostic (7.24e-2)" 173.7 44.4 37.6 82.2 38.6 20.6 69.7 31.7 60.8 52.6 51.2 102.5 110.4 30.8 36.8 64.5 36.6 145.8 85.3 40.0 40.3 205.9 111.1 107.3 177.0 35.6 37.3 33.0 37.9 247.0 24.9 262.1 42.4 51.9 105.9 19.7 56.4 32.2 50.4 32.7 97.6 65.0 35.9 202.2 107.0 29.8 62.8 52.8 93.2 50.4 54.9 144.7 52.1 49.4 33.2 47.5 30.8 57.4 94.3 76.0 108.4 70.3 67.0 71.7 84.2 36.9 58.6 18.2 101.5 116.5 44.3 81.5 0.0 60.8 33.7 1.6 36.2 1.2 24.4 42.8 27.7 1.0 2.7 54.2 29.1 68.4 39.4 21.3 82.1 33.7 7.4 150.9 5.2 45.2 8.9 1.2 15.1 208.2 32.1 8.4 27.1 898.6 59.2 129.1 33.6 23.2 97.9 59.4 53.0 66.8 43.9 0.6 47.2 35.3 44.8 64.5 21.8 462.5 58.0 25.0 20.0 0.2 69.1 1.9 1.6 0.1 0.8 3.1 1.6 17.0 5.1 1.3 19.3 14.5 15.2 9.0 1.6 3.7 1.0 209.2 9.7 7.0 37.6 38.6 31.7 60.8 40.0 40.3 35.6 37.3 42.4 35.9 62.8 49.4 34.9 57.7 128.0 8.8 33.9 23.1 37.5 36.0 22.2 10.6 31.2 37.6 29.8 42.9 48.1 31.3 93.8 181.8 24.5 64.2 9.8 61.3 1.3 79.4 23.5 38.3 36.5 22.7 19.2 50.6 140.2 63.8 73.4 177.7 8.8 17.6 276.3 46.4 1448.9 13.5 41.0 31.1 95.6 317.6 89.0 3.3 30.4 346.1 48.0 27.2 37.5 23.6 2.1 10.6 15.2 50.5 57.1 57.9 24.7 44.6 163.4 220.4 20.9 19.8 19.7 40.4 62.1 19.9 17.6 22.3 17.5 416.3 8.2 15.1 48.3 44.7 LMLN "Gp63, LMNL1, Msp" ENSG00000185621 "Leishmanolysin like peptidase" Q96KR4 3 197960200-198043720 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Cell cycle, Cell division, Mitosis" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 39.7;Endometrial ciliated cells: 35.2;Respiratory ciliated cells: 37.5;Spermatocytes: 33.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016481, HPA028844" Uncertain Supported "Focal adhesion sites,Cytosol" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 16: U-266 - Nucleosome" "Cluster 49: Ciliated cells - Cilium organization" Cytosol "Focal adhesion sites" "HPA016481: AB_1852955, HPA028844: AB_10602347" "unprognostic (2.54e-1)" "unprognostic (3.15e-1)" "unprognostic (7.63e-2)" "prognostic favorable (6.77e-4)" "unprognostic (1.14e-2)" "unprognostic (1.19e-1)" "unprognostic (1.30e-1)" "unprognostic (4.07e-2)" "unprognostic (1.94e-1)" "unprognostic (2.31e-1)" "unprognostic (6.36e-2)" "unprognostic (2.98e-1)" "unprognostic (4.82e-3)" "unprognostic (8.78e-2)" "unprognostic (7.65e-2)" "unprognostic (1.01e-1)" "unprognostic (1.63e-1)" 2.1 2.6 2.7 1.2 3.4 1.2 2.2 3.6 4.7 3.1 4.7 2.1 1.0 2.2 10.7 2.2 4.9 2.6 3.3 2.7 3.7 3.4 2.2 2.5 1.3 4.2 3.3 3.3 3.8 3.8 6.5 2.0 4.5 2.3 2.0 9.7 2.4 3.4 2.4 3.4 1.4 2.0 3.0 1.5 2.0 10.1 4.0 1.1 4.1 2.0 1.2 1.9 2.3 3.2 7.7 2.8 3.3 4.0 6.4 9.0 2.9 3.9 3.6 6.9 5.6 2.8 2.7 2.4 17.7 2.8 14.9 2.8 3.1 3.1 10.0 0.3 2.3 1.4 2.3 2.1 4.0 4.4 2.0 4.3 6.8 8.6 5.5 4.0 3.0 6.0 7.5 4.5 6.7 5.7 2.6 3.8 3.8 5.5 6.7 3.0 0.8 2.6 7.1 2.0 5.4 1.5 5.4 4.8 3.9 3.7 12.5 3.2 6.6 8.4 1.3 10.3 6.7 8.0 16.7 0.7 12.0 7.4 7.8 0.0 0.1 0.1 0.2 0.4 0.3 0.4 0.1 0.3 0.4 0.2 0.4 0.5 0.1 0.3 0.2 0.1 0.0 0.2 2.7 3.4 3.6 4.7 2.7 3.7 4.2 3.3 4.5 3.0 4.0 3.2 4.4 16.0 14.8 24.5 1.7 2.0 1.5 2.6 4.0 8.1 6.4 4.8 11.6 2.8 9.2 9.2 16.7 3.6 1.2 2.2 0.0 3.5 39.7 35.2 11.5 3.2 4.8 0.8 25.3 2.7 2.2 5.5 1.5 11.5 2.5 6.3 4.2 3.1 5.0 8.4 23.1 3.6 0.0 1.9 2.3 21.9 4.7 2.3 3.6 9.4 1.1 5.9 1.0 6.6 13.7 2.1 1.0 5.7 2.1 1.8 0.7 3.5 37.5 17.7 0.0 6.6 3.8 33.2 23.6 3.7 1.7 2.9 2.1 10.6 2.8 1.1 LMLN2 ENSG00000283654 "Leishmanolysin like peptidase 2" A0A1B0GTW7 14 23099062-23104989 "Enzymes, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at transcript level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Evidence at transcript level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 9 "HSkMC: 2.5" "Not detected" "Not detected" NA NA "Cluster 34: Mesenchymal cell lines - ECM organization" 0.1 0.1 0.1 0.1 0.4 0.2 0.1 0.2 0.3 0.0 0.5 0.1 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.3 0.3 0.1 0.0 0.0 0.3 0.0 0.3 0.1 0.1 0.1 0.0 0.0 0.0 0.2 0.1 0.0 0.1 0.1 0.0 0.2 0.3 0.0 0.2 0.0 0.2 0.0 0.0 0.4 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 2.5 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.2 0.3 0.1 0.2 0.3 0.3 0.3 0.1 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 LNPEP "CAP, IRAP, P-LAP, PLAP" ENSG00000113441 "Leucyl and cystinyl aminopeptidase" Q9UIQ6 5 96935394-97037513 "Enzymes, Predicted membrane proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "NK-cells: 257.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043642 Approved "Intracellular and membrane" NA NA 9800000 "Cluster 27: Non-specific - Gene expression" "Cluster 34: Non-specific - Transcription" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 63: NK-cells & T-cells - Immune response" "HPA043642: AB_10964137" "unprognostic (1.52e-1)" "unprognostic (5.39e-2)" "unprognostic (7.78e-2)" "unprognostic (1.53e-2)" "unprognostic (6.38e-2)" "unprognostic (6.59e-3)" "unprognostic (6.83e-2)" "unprognostic (2.11e-1)" "unprognostic (1.11e-1)" "unprognostic (3.54e-3)" "unprognostic (6.24e-2)" "unprognostic (2.08e-1)" "unprognostic (3.28e-1)" "unprognostic (4.13e-3)" "unprognostic (1.46e-1)" "unprognostic (1.69e-1)" "unprognostic (1.17e-1)" 11.4 4.4 8.4 12.2 10.6 16.2 8.2 17.9 8.6 6.8 4.0 8.1 5.2 6.5 5.1 9.0 5.7 5.1 12.0 8.5 10.0 8.3 4.3 7.7 19.4 10.0 9.4 8.8 4.9 15.3 5.8 9.1 10.7 8.8 7.9 9.4 6.0 8.5 11.2 16.4 8.2 7.7 8.6 12.5 7.9 4.1 9.2 17.8 8.4 12.7 18.7 7.0 7.0 10.3 10.7 11.9 5.4 5.6 32.5 15.4 6.2 10.5 13.8 12.0 18.1 9.9 16.4 52.2 19.1 14.1 33.7 13.4 6.8 20.1 12.5 18.2 3.8 12.9 8.2 7.3 8.4 15.5 16.9 12.0 12.5 17.5 13.3 13.6 12.8 11.6 5.6 32.7 13.9 9.6 18.1 10.9 1.1 3.4 6.2 12.7 19.8 7.9 44.9 21.2 10.2 2.7 12.8 11.4 6.4 5.2 34.1 20.2 26.6 17.6 9.6 13.9 16.3 7.3 17.4 45.6 16.1 14.5 8.2 4.3 2.6 3.6 5.9 4.2 5.0 2.3 4.4 4.6 2.8 3.1 4.2 4.7 3.1 9.0 11.2 2.6 4.2 3.6 8.4 10.6 17.9 8.6 8.5 10.0 10.0 9.4 10.7 8.6 9.2 10.3 43.4 35.3 41.3 52.2 91.0 59.4 21.3 28.4 37.5 58.9 24.9 18.8 80.8 22.8 27.2 36.8 125.1 12.3 108.4 20.7 5.9 15.4 3.6 21.4 28.9 33.6 25.7 38.9 47.5 14.4 24.3 36.6 30.1 28.9 25.9 29.3 30.7 16.7 16.2 23.5 50.9 29.6 22.4 49.3 35.9 5.3 32.9 52.0 21.4 45.9 59.7 33.6 257.5 49.3 73.9 21.5 17.5 46.6 44.9 27.4 16.6 10.7 25.8 38.4 26.3 46.8 36.6 29.4 27.5 44.4 47.2 27.4 97.3 31.1 25.6 23.2 LONP1 "hLON, LonHS, PIM1, PRSS15" ENSG00000196365 "Lon peptidase 1, mitochondrial" P36776 19 5691834-5720572 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "DNA-binding, Hydrolase, Protease, Serine protease" "Cataract, Deafness, Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 196.2" "Cell type enhanced" "Detected in all" "Theca cells: 85.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002034, HPA002192" Supported Enhanced Nucleoplasm,Mitochondria No No 7900 "Cluster 6: Non-specific - Transcription" "Cluster 35: Non-specific - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria Nucleoplasm "HPA002034: AB_2756304, HPA002192: AB_1079695" "unprognostic (6.52e-2)" "unprognostic (1.12e-1)" "unprognostic (2.43e-1)" "unprognostic (2.43e-2)" "unprognostic (2.84e-1)" "unprognostic (2.38e-1)" "unprognostic (1.66e-3)" "unprognostic (5.56e-2)" "unprognostic (2.71e-1)" "unprognostic (7.57e-2)" "unprognostic (4.04e-2)" "unprognostic (1.26e-1)" "unprognostic (1.76e-2)" "unprognostic (1.09e-2)" "unprognostic (1.24e-1)" "unprognostic (1.11e-1)" "unprognostic (2.11e-1)" 30.4 196.2 31.5 22.2 32.7 23.7 27.2 34.6 42.8 24.4 39.9 27.9 22.6 25.2 14.1 27.7 22.6 15.4 76.0 30.8 35.7 43.2 79.1 25.6 24.1 37.6 35.8 26.6 38.2 35.2 41.5 18.5 37.9 26.4 13.2 13.0 30.8 16.6 69.3 28.9 25.5 14.7 30.8 29.5 33.7 24.2 37.2 17.5 34.6 40.7 14.5 28.2 22.4 33.0 108.4 111.0 35.6 114.0 41.4 29.2 110.4 67.2 52.7 71.0 86.0 96.3 37.7 134.3 91.4 70.6 68.0 45.0 92.1 81.1 34.2 80.0 78.0 74.5 97.5 127.6 190.4 169.7 74.9 55.0 114.6 67.5 132.6 34.1 57.5 183.9 200.9 259.4 33.0 71.8 85.5 101.6 127.6 43.6 143.1 89.4 50.9 146.6 39.3 63.9 94.2 94.1 59.4 85.2 242.2 24.9 50.3 211.9 41.2 36.0 39.2 100.7 99.2 272.3 182.6 121.4 161.7 185.0 66.2 4.5 2.4 0.5 3.4 3.7 2.3 4.0 3.1 3.4 2.6 3.7 3.8 2.6 0.3 2.7 1.5 3.9 2.7 1.7 31.5 32.7 34.6 42.8 30.8 35.7 37.6 35.8 37.9 30.8 37.2 33.0 12.6 6.4 13.1 18.3 14.1 8.3 11.1 14.9 11.4 26.9 14.2 12.7 19.8 15.7 14.3 27.6 6.2 28.8 8.4 40.1 46.9 33.9 6.5 24.0 16.3 15.3 11.4 17.1 13.5 28.0 31.9 13.3 29.6 25.6 5.7 51.1 11.4 47.0 30.8 21.9 17.4 26.4 22.4 14.6 8.6 6.3 12.8 16.4 14.2 9.4 17.8 24.9 8.2 10.6 15.7 26.0 16.8 17.3 17.6 16.8 27.5 50.2 17.0 26.5 19.7 17.9 24.7 12.0 14.4 11.0 10.7 35.0 10.7 85.0 35.1 11.4 LONP2 "LONP, LONPL, MGC4840" ENSG00000102910 "Lon peptidase 2, peroxisomal" Q86WA8 16 48244300-48363122 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008862 Uncertain NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 85: Liver - Metabolism" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 52: Non-specific - Transcription" "HPA008862: AB_2137156" "unprognostic (8.08e-3)" "prognostic unfavorable (4.55e-4)" "unprognostic (1.75e-2)" "unprognostic (2.33e-2)" "unprognostic (6.08e-2)" "unprognostic (1.60e-2)" "unprognostic (7.59e-3)" "unprognostic (2.13e-1)" "unprognostic (2.36e-1)" "unprognostic (3.10e-2)" "unprognostic (5.39e-2)" "unprognostic (1.40e-1)" "prognostic favorable (6.71e-7)" "unprognostic (6.53e-2)" "unprognostic (1.49e-1)" "unprognostic (5.60e-2)" "unprognostic (1.33e-1)" 21.8 19.2 20.4 14.8 22.8 13.5 46.0 23.0 24.7 19.5 27.9 16.7 20.3 19.3 25.9 16.8 22.2 14.8 22.4 23.0 21.2 20.1 86.9 14.6 15.6 20.5 19.8 24.4 22.1 38.2 25.3 13.9 21.8 29.6 18.7 39.0 20.9 22.2 23.7 17.9 18.4 20.9 21.3 17.3 20.0 9.1 20.4 17.1 32.6 22.5 16.4 19.3 16.0 23.5 24.3 33.1 18.3 25.5 42.1 34.6 30.9 30.4 23.1 28.0 12.8 17.3 12.4 11.0 29.2 30.9 14.1 29.8 33.4 33.6 38.7 18.0 21.7 16.1 20.1 38.2 25.8 27.5 20.7 32.2 36.6 26.2 24.4 33.8 21.1 20.7 27.6 12.6 29.2 22.4 26.5 13.6 13.7 22.8 32.5 34.0 33.1 35.1 31.7 16.1 28.6 17.7 34.6 38.1 31.6 22.8 17.6 20.5 28.3 28.7 16.9 25.2 23.7 25.6 22.8 18.0 33.7 18.5 21.3 6.8 11.6 8.0 10.6 12.0 11.7 10.5 12.9 11.2 11.4 11.7 12.3 11.4 4.4 8.4 12.7 8.5 10.7 10.7 20.4 22.8 23.0 24.7 23.0 21.2 20.5 19.8 21.8 21.3 20.4 23.5 33.0 57.7 66.3 70.8 44.6 34.9 43.1 38.3 40.5 104.5 51.0 39.1 62.7 75.8 52.0 27.6 85.5 40.1 37.9 31.9 13.7 35.0 30.8 43.7 48.2 34.2 49.7 23.4 97.2 30.7 29.0 43.3 39.8 53.6 30.4 65.2 42.5 194.6 30.5 85.8 95.4 36.8 38.7 53.8 42.7 10.1 59.0 38.3 39.2 60.0 45.1 63.9 32.0 73.9 87.6 31.3 38.9 54.5 41.5 52.3 40.9 30.0 56.3 141.7 39.5 67.2 42.5 22.0 17.0 36.7 36.8 64.0 39.8 41.4 41.2 45.8 LPA "LP, Lp(a)" ENSG00000198670 Lipoprotein(a) P08519 6 160531482-160664275 "Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Lipid transport, Transport" "Hydrolase, Protease, Serine protease" Atherosclerosis "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 12 "liver: 76.7" "Cell type enriched" "Detected in some" 28 "Hepatocytes: 80.7" "Cancer enriched" "Detected in single" 38 "liver cancer: 3.6" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 6 "RT4: 1.0" "CAB016072, HPA060604" Supported "Secreted to blood" NA NA 78800000000 1800000000 "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 15: RT4 - Unknown function" "Cluster 15: Hepatocytes - Hemostasis" "CAB016072: AB_2135240, HPA060604: AB_2684330" "unprognostic (2.16e-1)" "unprognostic (5.10e-1)" "unprognostic (7.75e-3)" "unprognostic (6.70e-2)" "unprognostic (1.60e-1)" "unprognostic (4.17e-3)" "unprognostic (1.59e-1)" "unprognostic (6.38e-3)" "unprognostic (3.63e-2)" "unprognostic (3.18e-1)" "unprognostic (7.45e-3)" "unprognostic (2.56e-1)" "unprognostic (1.80e-1)" "unprognostic (1.34e-1)" "unprognostic (3.72e-2)" 0.0 0.1 2.0 0.0 1.2 0.0 0.0 0.0 1.1 0.1 0.0 0.0 0.0 0.2 0.4 0.1 0.8 0.0 0.0 0.8 6.3 0.5 76.7 0.1 0.0 1.8 1.9 0.2 0.6 0.0 0.0 0.0 1.3 0.6 0.0 0.2 0.0 1.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.5 4.2 1.1 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 1.2 0.0 1.1 0.8 6.3 1.8 1.9 1.3 0.2 4.2 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.5 2.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.1 0.1 0.0 0.2 0.0 2.7 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 80.7 0.0 0.0 1.3 0.0 0.0 2.5 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.9 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.3 LTA4H ENSG00000111144 "Leukotriene A4 hydrolase" P09960 12 96000753-96043520 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Leukotriene biosynthesis, Lipid metabolism" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hofbauer cells: 207.2;Kupffer cells: 255.8;monocytes: 245.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008399, CAB015221, HPA017017" Supported Approved Nucleoplasm,Cytosol NA NA 86000000 "Cluster 7: Monocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "Nucleoplasm, Cytosol" "CAB015221: , HPA008399: AB_1852816, HPA017017: AB_1852818" "prognostic favorable (9.79e-4)" "unprognostic (6.62e-2)" "unprognostic (6.04e-2)" "unprognostic (1.87e-1)" "unprognostic (1.38e-2)" "unprognostic (2.59e-2)" "unprognostic (4.25e-3)" "prognostic favorable (8.96e-4)" "unprognostic (1.72e-1)" "unprognostic (1.75e-2)" "unprognostic (3.38e-2)" "unprognostic (1.34e-1)" "unprognostic (1.73e-1)" "unprognostic (1.74e-1)" "unprognostic (1.04e-1)" "unprognostic (3.50e-2)" "unprognostic (1.34e-1)" 40.2 66.9 24.6 64.5 25.5 180.4 53.6 29.4 30.6 55.6 33.8 48.2 78.1 51.1 38.4 110.1 61.7 40.3 35.5 25.0 27.8 58.1 43.9 190.8 64.1 26.3 25.4 110.5 54.9 53.3 37.4 27.4 26.0 41.1 49.6 36.9 41.2 40.9 45.0 67.8 60.5 58.3 25.7 57.8 46.6 19.9 28.1 49.2 49.4 45.0 96.4 51.9 52.7 33.0 85.2 90.4 123.5 73.4 104.2 115.1 53.8 33.7 101.8 67.5 78.1 66.6 72.0 190.0 42.0 51.9 52.8 108.3 103.4 140.1 92.3 63.3 97.0 68.5 54.3 81.8 61.8 35.7 39.4 110.1 118.4 91.9 114.5 305.3 134.9 101.1 42.9 32.5 98.7 59.2 96.7 115.0 145.8 100.7 115.5 88.9 90.5 109.7 125.7 107.7 63.9 75.5 64.2 80.4 78.3 95.1 98.7 44.7 49.0 28.3 47.6 40.2 38.2 42.8 79.4 85.4 19.1 66.2 22.3 4.4 662.9 17.7 33.4 699.2 63.4 126.1 46.6 43.4 282.3 157.5 65.0 50.5 46.0 120.4 638.8 70.4 51.2 591.5 24.6 25.5 29.4 30.6 25.0 27.8 26.3 25.4 26.0 25.7 28.1 33.0 32.8 38.5 135.0 15.3 82.8 51.9 64.8 96.6 52.3 21.4 41.8 41.1 25.3 25.8 110.2 38.6 33.3 29.3 47.9 17.6 74.3 42.9 74.3 18.4 20.8 38.2 21.6 50.5 21.3 28.0 28.2 29.7 38.2 27.3 7.6 31.5 57.8 21.7 207.2 11.8 18.5 40.4 40.7 255.8 76.6 16.4 36.7 183.3 21.4 10.3 245.5 35.5 26.8 19.6 17.5 20.8 27.1 41.0 40.1 35.4 73.2 69.3 45.0 55.6 6.6 26.7 35.4 46.9 11.6 108.0 74.9 20.8 39.1 32.9 70.4 49.7 LVRN "APQ, AQPEP, FLJ90650, TAQPEP" ENSG00000172901 Laeverin Q6Q4G3 5 115962454-116027619 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 8 "adipose tissue: 11.1;placenta: 21.8" "Group enriched" "Detected in some" 4 "Early spermatids: 29.3;Extravillous trophoblasts: 33.1;Late spermatids: 68.1" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in single" 8 "spinal cord: 2.5" HPA053254 Enhanced "Intracellular and membrane" NA NA "Cluster 28: Placenta - Pregnancy" "Cluster 50: Fibroblasts - ECM organization" "HPA053254: AB_2682092" "unprognostic (1.47e-1)" "unprognostic (3.38e-3)" "unprognostic (5.81e-2)" "unprognostic (2.97e-3)" "unprognostic (5.38e-2)" "unprognostic (1.32e-1)" "unprognostic (2.59e-3)" "unprognostic (1.88e-2)" "unprognostic (2.23e-1)" "unprognostic (2.23e-2)" "unprognostic (3.83e-3)" "unprognostic (1.22e-1)" "unprognostic (1.67e-7)" "unprognostic (1.05e-2)" "unprognostic (5.94e-2)" "unprognostic (6.53e-2)" "unprognostic (3.31e-2)" 11.1 0.0 0.0 0.0 0.0 0.1 2.0 0.0 0.1 0.2 0.0 0.5 0.1 0.0 0.0 0.3 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 21.8 0.0 0.0 0.4 0.0 0.2 0.1 0.3 0.4 0.8 0.3 0.0 0.0 0.1 0.1 0.0 0.1 0.1 1.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.9 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.5 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.1 29.3 0.0 0.1 0.1 0.0 0.0 2.1 0.0 33.1 7.9 0.5 0.0 0.0 0.0 0.0 0.0 1.2 0.0 1.8 0.0 0.0 0.0 0.0 68.1 4.7 0.3 0.0 1.9 0.0 0.0 0.0 3.0 1.5 0.0 0.0 0.4 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.0 0.4 0.3 0.3 0.1 0.0 10.7 0.0 1.0 0.0 0.1 MALT1 "MLT, PCASP1" ENSG00000172175 "MALT1 paracaspase" Q9UDY8 18 58671465-58754477 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Immunity, Ubl conjugation pathway" "Hydrolase, Protease" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "RPTEC TERT1: 88.9" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB004494, HPA048432" Enhanced Approved "Nucleoli fibrillar center,Cytosol" No No "Cluster 21: B-cells - Adaptive immune response" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 65: Plasmacytoid DCs - Unknown function" "Nucleoli fibrillar center" Cytosol "CAB004494: AB_627909, HPA048432: AB_2680389" "unprognostic (3.25e-1)" "unprognostic (2.31e-1)" "unprognostic (3.64e-2)" "unprognostic (3.25e-2)" "unprognostic (1.65e-3)" "unprognostic (4.67e-2)" "unprognostic (6.46e-2)" "unprognostic (4.50e-2)" "unprognostic (3.33e-2)" "unprognostic (4.16e-3)" "unprognostic (3.74e-1)" "unprognostic (2.07e-1)" "unprognostic (2.53e-2)" "unprognostic (2.34e-1)" "unprognostic (2.97e-1)" "unprognostic (1.03e-1)" "unprognostic (6.00e-2)" 7.1 2.5 2.9 11.2 2.8 10.5 6.3 4.8 3.6 7.7 4.2 5.1 3.6 5.4 4.2 12.5 5.1 5.8 5.4 3.1 4.1 6.7 6.9 7.3 21.1 3.2 2.6 5.3 4.0 5.3 4.7 4.0 3.0 11.5 5.5 8.7 5.8 3.8 8.3 9.4 7.7 4.2 3.0 11.5 4.6 8.2 4.1 15.6 5.3 2.8 23.1 7.1 9.6 3.6 11.4 16.0 16.8 5.2 3.1 6.7 9.2 19.7 12.1 15.7 12.6 13.8 13.5 27.0 10.3 24.0 11.1 12.0 10.8 7.6 20.8 17.0 6.8 9.7 9.0 21.8 4.0 20.1 11.4 4.0 12.2 11.8 10.4 6.6 3.4 7.7 15.3 42.3 9.6 3.3 4.7 9.7 6.3 4.1 7.1 14.8 11.5 19.7 88.9 2.8 2.5 4.5 11.7 6.0 9.3 12.0 5.1 12.2 5.7 22.6 9.1 7.1 20.8 38.5 54.4 16.3 10.6 15.6 9.9 0.3 0.5 0.2 0.7 0.7 0.6 1.1 1.4 0.8 0.7 2.1 1.0 0.8 0.3 0.5 0.5 1.3 0.8 0.4 2.9 2.8 4.8 3.6 3.1 4.1 3.2 2.6 3.0 3.0 4.1 3.6 35.0 22.4 19.2 24.2 67.8 33.0 32.3 4.8 26.2 14.7 13.6 11.0 14.4 10.0 7.0 11.0 85.5 6.2 53.2 11.1 3.9 16.6 12.7 10.4 17.5 31.1 6.7 0.8 61.3 8.5 6.0 15.7 13.7 24.7 31.7 28.1 10.4 11.1 11.8 55.5 42.9 8.6 8.2 21.0 96.5 8.0 10.2 55.9 12.4 34.7 79.5 26.2 20.6 52.3 11.9 16.2 21.9 7.2 42.2 46.6 8.0 30.7 5.8 18.1 19.7 16.1 12.9 40.1 35.6 25.4 24.7 9.0 55.2 5.7 10.7 38.1 MASP1 "CRARF, MASP, PRSS5" ENSG00000127241 "Mannan binding lectin serine peptidase 1" P48740 3 187217282-187291980 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Complement activation lectin pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "cervix: 120.0;heart muscle: 116.1;liver: 183.4" "Cell type enhanced" "Detected in some" "Astrocytes: 28.1;Cardiomyocytes: 38.1;Cholangiocytes: 20.0;Endometrial stromal cells: 30.6;Fibroblasts: 16.4;Hepatic stellate cells: 23.2;Hepatocytes: 65.8" "Group enriched" "Detected in some" 9 "glioma: 6.8;liver cancer: 7.7;prostate cancer: 3.0;renal cancer: 3.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "BJ: 133.3;BJ hTERT+: 498.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001617, HPA009641" Supported Enhanced Nucleoplasm,Cytosol "Secreted to blood" No NA 8670000000 1900000000 "Cluster 85: Liver - Metabolism" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Nucleoplasm, Cytosol" "HPA001617: AB_1079314, HPA009641: AB_1079313" "unprognostic (1.67e-1)" "unprognostic (1.02e-2)" "unprognostic (1.99e-1)" "unprognostic (5.20e-2)" "unprognostic (1.02e-2)" "unprognostic (1.25e-6)" "prognostic favorable (2.20e-4)" "unprognostic (9.92e-2)" "unprognostic (3.22e-1)" "unprognostic (2.29e-1)" "unprognostic (4.18e-1)" "unprognostic (1.29e-1)" "unprognostic (2.82e-3)" "unprognostic (3.56e-3)" "unprognostic (1.97e-1)" "unprognostic (7.85e-2)" "unprognostic (4.29e-1)" 6.3 3.6 9.4 1.3 9.4 0.0 2.8 12.9 7.0 120.0 4.9 57.5 1.9 88.4 3.3 11.1 17.7 5.1 116.1 10.4 27.0 4.8 183.4 6.0 1.0 19.2 16.5 2.7 0.2 0.3 1.0 9.0 15.3 46.0 5.6 0.0 2.3 52.2 37.5 6.3 7.5 44.4 22.2 0.8 1.6 0.5 14.6 0.2 3.2 18.9 4.3 9.9 61.5 32.0 0.0 0.0 0.3 0.4 15.7 17.3 0.1 133.3 498.3 1.8 0.9 0.0 0.0 0.1 0.0 40.8 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.4 2.6 0.0 0.0 2.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.6 0.0 0.2 0.0 0.1 0.2 0.0 0.0 5.4 0.0 0.0 0.0 0.0 4.9 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.6 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.4 9.4 12.9 7.0 10.4 27.0 19.2 16.5 15.3 22.2 14.6 32.0 1.1 0.0 1.8 28.1 0.2 2.9 0.1 0.2 0.0 0.0 0.0 0.0 38.1 20.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.9 0.7 30.6 2.0 0.0 0.0 0.2 0.0 0.3 16.4 0.0 0.7 0.0 0.2 23.2 65.8 0.4 0.0 0.9 0.0 0.0 1.9 3.7 7.5 2.5 0.3 1.8 1.0 0.0 0.0 0.0 10.1 0.2 0.0 0.0 0.7 0.1 0.1 0.0 2.4 0.0 0.0 0.0 5.4 4.5 0.0 0.0 0.2 1.7 0.1 0.5 5.1 0.0 0.1 MASP2 MASP1P1 ENSG00000009724 "Mannan binding lectin serine peptidase 2" O00187 1 11026523-11047239 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins" "Complement pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 64 "liver: 476.5" "Cell type enriched" "Detected in some" 52 "Hepatocytes: 658.6" "Cancer enriched" "Detected in some" 71 "liver cancer: 41.9" "Region enriched" "Detected in single" 9 "cerebellum: 6.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 6 "Hep G2: 16.4" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA029313, HPA029314" Uncertain Supported "Golgi apparatus" "Secreted to blood" NA NA 340000000 820000000 "Cluster 62: Liver - Hemostasis" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" "Golgi apparatus" "HPA029313: AB_10669654, HPA029314: AB_10670029" "unprognostic (7.00e-2)" "unprognostic (8.37e-2)" "unprognostic (2.75e-2)" "unprognostic (2.89e-1)" "unprognostic (1.86e-1)" "unprognostic (3.26e-3)" "prognostic favorable (1.60e-4)" "unprognostic (2.92e-3)" "unprognostic (3.13e-2)" "unprognostic (4.04e-2)" "unprognostic (6.90e-3)" "unprognostic (8.30e-4)" "unprognostic (7.14e-2)" "unprognostic (3.91e-1)" "unprognostic (2.62e-2)" "unprognostic (1.05e-1)" "unprognostic (1.09e-4)" 2.1 1.2 0.0 1.7 0.0 7.4 2.2 6.4 0.7 2.4 0.0 2.7 1.6 2.8 0.0 1.2 2.7 1.2 1.3 0.1 0.0 1.0 476.5 1.8 2.7 0.0 0.0 2.9 2.9 0.0 2.3 0.6 0.2 1.6 0.0 6.9 2.5 0.0 5.1 5.3 3.4 0.0 0.0 2.5 2.4 1.5 0.0 0.0 1.9 0.0 0.0 2.1 1.6 0.4 0.5 0.3 2.6 1.6 0.0 0.1 0.4 0.7 0.0 0.0 0.0 1.2 1.0 2.3 0.6 0.0 0.5 0.7 0.0 0.0 0.0 0.6 2.3 1.3 2.7 16.4 0.0 2.0 1.5 0.0 0.0 0.1 0.0 1.8 0.0 1.7 0.7 0.5 0.0 0.5 0.6 1.1 0.3 0.2 0.7 1.6 0.9 0.6 0.0 1.3 1.7 0.7 0.9 0.4 0.4 1.6 0.6 1.2 1.2 0.9 0.5 0.8 0.5 0.5 0.9 1.5 0.5 1.7 0.4 0.1 0.0 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 6.4 0.7 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.4 0.0 0.0 0.0 4.6 1.1 0.9 0.2 0.0 0.6 0.2 0.2 0.0 0.5 4.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.9 0.0 5.3 9.5 0.0 0.0 0.1 0.0 0.1 1.3 0.0 8.2 658.6 0.1 0.0 8.3 0.0 0.0 12.6 0.3 0.0 0.0 0.0 1.8 1.9 0.0 0.1 0.0 8.0 10.4 0.0 0.0 0.0 0.0 0.2 0.0 0.5 0.7 0.4 0.0 0.7 0.2 0.0 0.0 0.4 0.6 0.0 0.8 0.1 0.0 0.1 MBTPS1 "KIAA0091, PCSK8, S1P, SKI-1" ENSG00000140943 "Membrane bound transcription factor peptidase, site 1" Q14703 16 84053761-84116942 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Hydrolase, Protease, Serine protease" "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Rod photoreceptor cells: 318.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056109 Supported NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA056109: AB_2683040" "unprognostic (1.50e-1)" "unprognostic (9.73e-2)" "unprognostic (1.58e-1)" "unprognostic (3.10e-3)" "unprognostic (1.20e-1)" "unprognostic (1.20e-1)" "unprognostic (2.50e-1)" "unprognostic (2.02e-1)" "unprognostic (1.47e-1)" "unprognostic (1.59e-1)" "unprognostic (1.00e-2)" "unprognostic (2.19e-1)" "prognostic favorable (2.21e-5)" "unprognostic (2.62e-1)" "unprognostic (2.92e-1)" "unprognostic (6.63e-2)" "unprognostic (6.88e-2)" 45.8 33.7 12.7 26.2 16.4 24.6 42.8 17.6 13.3 41.2 18.1 38.7 26.0 40.8 25.6 28.2 45.6 32.2 44.6 13.1 17.8 36.7 27.5 35.5 27.5 6.3 8.0 49.4 36.4 58.5 38.8 37.1 8.9 37.3 33.7 108.7 42.4 40.3 18.9 27.8 26.4 41.2 5.9 30.1 30.7 19.6 16.5 33.4 53.9 35.6 29.9 35.2 21.3 8.6 49.4 61.3 53.8 75.2 124.2 100.1 42.2 81.2 124.4 70.2 52.6 43.7 71.0 47.0 82.0 117.3 55.8 52.9 50.2 56.3 77.9 42.6 55.9 34.4 55.8 61.3 59.9 84.2 72.7 103.6 79.9 64.8 55.5 100.3 92.4 62.2 45.6 40.3 43.1 85.0 46.6 46.4 50.3 27.7 43.2 59.6 28.7 34.1 56.1 40.2 41.0 51.2 156.9 42.9 62.1 58.3 134.3 76.4 99.0 72.3 52.5 43.7 38.7 50.5 102.6 90.5 52.6 50.6 45.2 8.0 16.3 15.0 16.3 13.8 16.8 11.3 14.0 15.4 12.8 9.6 16.9 15.3 4.5 17.0 11.6 7.1 9.6 18.3 12.7 16.4 17.6 13.3 13.1 17.8 6.3 8.0 8.9 5.9 16.5 8.6 54.3 48.1 50.7 27.1 33.5 13.8 24.2 25.9 19.9 68.4 62.2 56.1 50.5 44.3 41.9 25.8 166.8 24.4 41.0 28.9 11.7 24.1 0.9 70.4 67.8 39.8 34.9 19.4 50.4 27.5 21.4 48.4 23.0 92.7 29.1 103.1 36.0 33.8 16.7 84.1 53.5 26.6 28.5 21.0 10.8 5.5 53.4 23.3 19.6 36.5 22.5 44.4 29.9 57.8 39.0 30.2 24.8 50.4 59.3 30.1 20.3 17.5 56.4 318.6 26.3 60.9 42.2 12.6 24.2 23.4 15.8 21.6 34.3 75.5 33.8 28.6 MBTPS2 "KFSD, S2P" ENSG00000012174 "Membrane bound transcription factor peptidase, site 2" O43462 X 21839617-21885423 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins" "Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Hydrolase, Metalloprotease, Protease" "Disease variant, Ichthyosis, Osteogenesis imperfecta, Palmoplantar keratoderma" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005494, CAB009486" Approved Approved Nucleoplasm,Mitochondria,Cytosol NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 85: Liver - Metabolism" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Mitochondria, Cytosol" "CAB009486: AB_2140370, HPA005494: AB_1079329" "unprognostic (7.97e-3)" "unprognostic (9.12e-2)" "unprognostic (5.38e-2)" "unprognostic (1.18e-2)" "unprognostic (2.65e-1)" "unprognostic (1.50e-1)" "unprognostic (1.85e-1)" "unprognostic (7.22e-2)" "unprognostic (3.32e-1)" "unprognostic (9.30e-2)" "unprognostic (1.99e-1)" "unprognostic (1.77e-1)" "unprognostic (8.38e-2)" "unprognostic (7.76e-2)" "unprognostic (1.07e-1)" "unprognostic (3.61e-1)" "unprognostic (3.05e-2)" 8.6 10.6 3.5 5.2 4.0 1.7 8.8 7.8 4.9 7.5 4.5 5.1 5.2 9.7 6.0 5.8 7.3 6.7 7.7 3.7 4.1 9.4 18.7 5.5 5.0 4.4 4.1 12.5 7.3 11.0 3.8 11.6 4.9 10.5 6.0 8.8 6.6 8.5 7.1 3.7 4.2 10.1 4.1 4.8 5.8 4.1 4.2 4.9 9.0 9.1 4.7 6.8 4.0 6.1 16.9 34.5 16.1 16.5 19.8 24.4 7.7 24.4 24.7 22.7 19.7 13.8 22.5 14.6 12.4 26.2 44.4 15.4 22.4 14.0 27.9 10.9 17.8 7.2 19.7 11.4 27.1 15.6 6.8 23.2 14.8 34.3 25.1 23.0 17.8 8.4 20.3 15.8 26.1 10.5 6.4 8.1 15.0 8.8 25.1 7.9 29.8 16.4 15.7 8.4 3.9 32.8 34.3 21.5 30.5 21.3 28.9 13.2 21.2 28.4 6.6 41.9 18.5 19.1 26.0 6.9 31.6 6.4 28.0 0.0 2.2 0.8 2.2 2.5 2.0 1.9 1.6 2.0 3.6 1.7 2.2 2.6 0.2 2.6 2.6 2.4 3.2 1.7 3.5 4.0 7.8 4.9 3.7 4.1 4.4 4.1 4.9 4.1 4.2 6.1 5.5 9.6 11.5 16.6 5.8 5.5 4.8 7.0 8.0 11.8 7.5 5.1 13.3 8.6 7.1 7.3 18.8 7.0 2.2 3.8 0.0 5.9 0.3 4.0 11.5 5.6 2.4 2.1 16.8 8.9 7.1 10.8 6.1 3.7 10.8 14.5 7.5 18.7 9.4 30.3 25.0 3.4 12.2 9.2 4.0 1.9 10.5 4.8 10.6 11.2 5.0 7.3 3.1 21.6 22.2 6.1 2.4 13.2 9.1 7.4 4.9 7.2 10.7 14.5 0.0 8.6 8.3 2.7 1.5 6.5 2.7 4.8 5.1 12.3 4.3 4.9 METAP1 "KIAA0094, MAP1A, MetAP1A" ENSG00000164024 "Methionyl aminopeptidase 1" P53582 4 98995659-99062809 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in all" 4 "Late spermatids: 1627.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025485, HPA037997, HPA037998" Approved Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA 8900 "Cluster 44: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" Cytosol "Nucleoplasm, Plasma membrane" "CAB025485: , HPA037997: AB_2675777, HPA037998: AB_2675778" "unprognostic (1.79e-1)" "unprognostic (3.39e-1)" "prognostic favorable (7.22e-4)" "unprognostic (1.58e-2)" "unprognostic (6.53e-2)" "unprognostic (2.15e-1)" "prognostic unfavorable (3.08e-5)" "unprognostic (1.09e-1)" "unprognostic (1.51e-3)" "unprognostic (2.05e-1)" "prognostic unfavorable (2.28e-5)" "unprognostic (2.00e-1)" "prognostic favorable (1.72e-4)" "unprognostic (5.50e-2)" "unprognostic (8.51e-2)" "unprognostic (1.15e-3)" "prognostic favorable (9.31e-4)" 14.8 9.5 10.2 20.5 11.6 25.1 28.7 10.5 13.8 24.0 8.8 31.8 24.1 25.7 43.7 52.3 24.3 15.1 41.1 11.2 10.0 24.7 24.0 15.6 24.9 9.5 10.1 14.0 19.5 14.0 11.6 16.9 9.4 29.2 33.5 11.3 23.1 29.7 33.8 28.7 23.4 25.7 9.2 17.6 19.6 51.6 10.6 41.9 18.8 28.7 31.2 34.5 30.8 10.4 57.6 55.9 47.7 51.7 37.2 59.1 52.9 80.3 51.5 67.1 63.7 62.9 83.3 84.1 31.3 65.5 40.3 56.1 84.8 80.5 92.9 59.2 39.9 75.6 37.8 68.2 40.2 103.6 60.8 42.8 57.5 57.0 60.4 52.4 56.3 46.9 60.0 49.7 73.2 44.0 90.9 49.3 58.7 97.7 44.3 58.9 74.5 45.4 109.2 73.6 64.7 38.5 27.0 82.5 32.8 53.1 31.6 39.3 46.1 53.9 68.0 49.9 70.9 35.5 53.5 66.2 46.5 51.9 54.8 19.1 11.6 5.7 17.7 14.6 23.1 16.0 18.0 17.6 14.9 11.4 17.4 15.8 2.9 17.7 14.7 7.2 17.7 14.1 10.2 11.6 10.5 13.8 11.2 10.0 9.5 10.1 9.4 9.2 10.6 10.4 16.1 41.7 14.6 20.2 19.8 42.4 47.5 26.2 51.2 5.2 21.0 24.9 57.0 17.2 19.5 14.7 2.1 24.4 17.4 36.7 13.7 28.4 330.3 45.4 30.0 17.3 7.8 24.2 22.6 29.4 70.5 15.3 22.4 60.9 3.8 16.9 12.8 21.4 17.2 3.3 15.0 23.3 24.4 20.2 16.2 1627.3 19.3 17.4 16.0 14.0 13.9 10.6 25.7 17.6 22.3 28.0 30.8 22.6 17.8 34.4 25.3 31.6 17.2 3.7 26.3 11.5 21.7 15.7 41.6 54.3 38.8 7.7 23.6 18.1 36.2 46.9 METAP1D "MAP1D, Metap1l" ENSG00000172878 "Methionyl aminopeptidase type 1D, mitochondrial" Q6UB28 2 171999943-172082430 "Enzymes, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Inhibitory neurons: 39.5;Oligodendrocyte precursor cells: 35.7;Oligodendrocytes: 35.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030298, HPA030299, HPA077742" Uncertain Uncertain Vesicles NA NA "Cluster 32: T-cells - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 1: K-562 - Erythropoiesis" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles "HPA030298: AB_2673419, HPA030299: AB_10602421, HPA077742: " "unprognostic (5.31e-2)" "unprognostic (1.07e-1)" "unprognostic (1.88e-1)" "unprognostic (5.83e-2)" "unprognostic (2.54e-2)" "unprognostic (7.90e-3)" "unprognostic (1.92e-3)" "unprognostic (1.07e-2)" "unprognostic (4.55e-1)" "unprognostic (7.07e-2)" "unprognostic (2.64e-2)" "unprognostic (8.19e-2)" "unprognostic (2.53e-3)" "unprognostic (3.44e-3)" "unprognostic (3.06e-2)" "unprognostic (5.48e-3)" "unprognostic (2.92e-2)" 4.4 4.9 4.3 2.4 4.5 3.5 3.9 3.7 5.0 5.4 3.7 4.6 2.3 4.5 2.8 3.4 6.7 2.0 4.8 4.1 5.1 4.5 6.0 2.3 2.8 4.1 4.1 11.9 8.1 2.2 4.3 1.8 4.6 5.6 3.2 2.5 4.1 3.7 7.8 3.4 4.1 2.8 3.6 5.8 4.6 2.8 4.3 1.2 3.6 5.6 2.0 4.2 3.8 5.0 3.6 2.8 4.1 13.5 5.9 7.7 8.3 4.1 4.1 6.4 4.1 6.4 4.7 1.8 7.2 4.3 6.6 6.4 9.1 7.2 6.5 6.3 10.6 10.2 7.8 8.6 6.2 6.1 2.6 5.8 10.9 6.4 10.2 5.5 3.6 6.9 14.8 5.1 4.9 4.4 3.5 8.2 7.4 10.4 3.4 7.7 3.5 3.3 4.5 5.0 8.4 3.2 2.9 5.8 10.2 3.6 6.7 8.1 4.4 8.1 6.4 5.0 4.0 6.3 6.1 4.0 5.8 11.9 7.9 0.0 0.0 0.0 0.4 0.4 0.2 0.3 0.5 0.2 0.1 0.7 0.5 1.1 0.0 0.4 0.0 0.0 0.4 0.2 4.3 4.5 3.7 5.0 4.1 5.1 4.1 4.1 4.6 3.6 4.3 5.0 6.1 0.0 4.6 23.8 15.4 5.6 10.3 7.5 22.8 5.8 9.2 8.9 4.5 7.2 3.5 3.7 2.1 4.1 2.7 1.3 7.9 2.5 1.2 2.7 14.7 5.4 0.0 16.8 19.6 3.5 4.7 10.9 8.2 2.5 4.5 17.9 6.4 6.4 3.9 5.0 39.5 2.9 2.0 2.5 2.2 2.3 33.5 2.2 5.4 14.0 1.0 3.7 9.2 35.7 35.5 1.4 1.3 26.4 9.9 4.3 0.6 5.7 2.0 6.1 13.1 18.1 9.5 9.8 12.2 11.6 5.7 1.9 7.5 14.5 5.7 5.1 METAP2 "MAP2, MNPEP, p67" ENSG00000111142 "Methionyl aminopeptidase 2" P50579 12 95473520-95515839 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013025, HPA019095" Enhanced Supported "Plasma membrane,Cytosol" NA NA 70000 "Cluster 6: Non-specific - Transcription" "Cluster 52: Non-specific - Ribosome" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 10: Non-specific - Unknown function" "Plasma membrane, Cytosol" "CAB013025: AB_2533993, HPA019095: AB_1853823" "unprognostic (1.91e-1)" "unprognostic (1.02e-1)" "unprognostic (5.92e-2)" "unprognostic (2.44e-1)" "unprognostic (3.27e-2)" "unprognostic (2.57e-2)" "prognostic unfavorable (4.51e-6)" "unprognostic (1.25e-1)" "unprognostic (2.28e-2)" "unprognostic (1.40e-2)" "unprognostic (8.53e-2)" "unprognostic (1.66e-1)" "unprognostic (1.49e-1)" "unprognostic (2.51e-1)" "unprognostic (1.07e-1)" "unprognostic (2.95e-2)" "unprognostic (1.03e-1)" 52.5 58.0 41.1 51.6 44.5 102.2 55.0 45.0 53.2 46.0 39.7 50.7 36.7 54.2 52.6 54.7 42.6 47.0 65.9 40.2 49.9 55.6 84.5 49.0 78.0 46.5 43.8 60.5 52.7 52.3 36.6 51.3 48.8 43.3 50.9 30.8 40.6 101.0 119.5 58.3 37.7 54.9 42.4 40.3 37.4 61.8 44.7 69.1 51.8 78.7 125.0 62.2 41.5 50.2 192.3 157.8 163.7 129.6 98.4 156.4 125.9 186.0 127.6 177.7 125.7 228.0 88.6 542.1 113.5 133.4 101.9 120.5 187.4 142.4 203.8 131.2 161.2 244.9 113.7 165.6 104.5 313.5 117.1 137.5 148.1 164.9 164.0 210.7 192.9 184.2 321.8 60.5 135.3 125.8 230.3 213.0 204.5 109.4 233.4 179.6 141.5 178.5 123.5 198.3 127.0 165.3 166.0 132.7 169.0 140.6 159.4 146.5 165.1 100.7 98.5 115.0 195.7 87.7 246.8 585.1 58.1 173.7 129.9 77.5 70.5 32.0 60.0 52.2 74.3 114.2 66.8 67.8 66.0 101.8 79.2 74.1 3.4 72.8 65.6 85.3 71.6 46.4 41.1 44.5 45.0 53.2 40.2 49.9 46.5 43.8 48.8 42.4 44.7 50.2 87.0 282.0 238.9 22.9 101.3 233.2 130.2 141.3 97.3 70.6 119.7 95.9 143.6 100.1 133.3 290.6 66.7 146.2 87.7 96.8 164.4 115.2 189.5 114.9 260.0 110.2 91.7 278.4 35.1 145.8 161.5 112.2 53.0 153.7 122.9 140.5 112.1 314.6 98.1 75.7 49.5 119.7 73.2 141.0 89.8 123.3 100.3 83.8 92.5 20.6 103.5 72.6 81.4 26.2 41.4 130.1 105.8 106.8 87.0 108.1 93.4 186.6 92.4 83.8 98.6 137.4 133.4 378.4 207.6 95.2 215.0 172.0 80.7 101.4 144.8 110.5 MIPEP MIP ENSG00000027001 "Mitochondrial intermediate peptidase" Q99797 13 23730189-23889400 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 108.0;Oligodendrocytes: 62.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "OE19: 64.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030676, HPA031669, HPA031670" Approved Enhanced Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 8: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 54: Cardiomyocytes - Muscle contraction" Mitochondria "HPA030676: AB_10598907, HPA031669: AB_10600986, HPA031670: AB_10602198" "unprognostic (2.05e-1)" "unprognostic (3.17e-2)" "unprognostic (3.75e-3)" "unprognostic (3.72e-2)" "unprognostic (1.24e-1)" "unprognostic (1.23e-1)" "unprognostic (2.41e-1)" "unprognostic (2.21e-1)" "unprognostic (4.69e-2)" "unprognostic (1.12e-1)" "unprognostic (7.54e-2)" "unprognostic (4.76e-1)" "prognostic favorable (7.66e-12)" "unprognostic (1.62e-2)" "unprognostic (4.95e-2)" "unprognostic (2.79e-1)" "unprognostic (6.90e-3)" 6.3 9.6 3.7 6.2 4.3 5.3 11.1 3.2 5.0 7.5 13.4 12.9 8.8 7.2 12.4 11.5 17.3 7.7 18.4 14.4 4.0 25.4 12.0 7.1 5.1 4.0 5.0 5.4 8.2 14.6 5.4 4.7 4.6 10.9 13.1 6.1 9.7 8.7 13.9 21.4 7.6 7.8 4.0 4.3 8.6 9.8 3.7 6.0 11.1 16.9 7.8 7.7 6.4 4.9 14.6 16.1 7.8 18.4 17.4 23.4 16.6 10.3 16.0 15.1 12.7 21.7 28.1 17.0 10.2 8.4 13.3 35.8 18.1 21.6 18.8 9.9 11.5 7.4 7.0 18.8 14.3 17.5 3.9 11.6 26.4 15.7 13.9 12.7 19.2 12.7 14.5 2.7 24.0 10.8 12.6 9.8 10.8 64.8 16.1 13.8 21.0 14.8 33.7 9.6 18.2 6.1 11.0 17.8 21.8 9.8 18.3 9.7 10.7 9.2 7.6 15.3 11.2 2.6 4.0 9.1 15.9 8.8 11.7 0.0 3.0 1.3 7.4 3.7 9.3 8.7 7.1 6.8 6.5 7.2 6.7 6.7 0.0 10.3 12.0 5.5 5.2 4.0 3.7 4.3 3.2 5.0 14.4 4.0 4.0 5.0 4.6 4.0 3.7 4.9 2.5 16.0 8.6 18.9 5.9 39.9 7.7 13.8 6.2 3.6 6.2 5.8 108.0 11.5 12.6 9.2 6.2 9.8 2.4 8.2 29.4 23.4 8.2 26.0 8.5 5.4 6.0 4.6 43.8 10.6 9.3 8.0 7.1 8.5 2.5 4.2 3.6 5.9 9.7 15.2 47.5 7.1 14.2 3.5 5.0 7.4 6.8 4.3 5.4 12.2 3.4 5.5 5.2 18.1 62.8 8.6 7.0 8.6 4.9 7.5 6.6 25.6 46.3 11.4 0.0 7.3 5.7 9.7 19.0 10.1 42.3 5.1 4.0 8.9 13.6 5.6 MME "CALLA, CD10, NEP" ENSG00000196549 "Membrane metalloendopeptidase" P08473 3 155024124-155183704 "Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, Charcot-Marie-Tooth disease, Disease variant, FDA approved drug targets, Neurodegeneration, Neuropathy, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 333.5;kidney: 302.5" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 273.3;Proximal enterocytes: 372.4;Proximal tubular cells: 125.7;Syncytiotrophoblasts: 126.0" "Cancer enhanced" "Detected in many" "prostate cancer: 17.6" "Group enriched" "Detected in many" 5 "basal ganglia: 17.3;medulla oblongata: 9.3;pons: 10.9;thalamus: 4.6" "Immune cell enriched" "Detected in some" 122 "neutrophil: 139.4" "Lineage enriched" "Detected in many" 122 "granulocytes: 139.4" "Cell line enhanced" "Detected in many" "ASC TERT1: 684.4;BJ hTERT+: 1116.9;HSkMC: 651.1" "Region enhanced" "Detected in many" "basal ganglia: 28.1" "Group enriched" "Detected in many" 4 "basal ganglia: 32.3;olfactory bulb: 8.5;spinal cord: 15.9" "CAB000013, HPA052583, HPA056072" Enhanced NA NA 320000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 45: Enterocytes - Digestion" "CAB000013: AB_563478, HPA052583: AB_2681872, HPA056072: AB_2683027" "unprognostic (1.36e-1)" "unprognostic (1.02e-3)" "unprognostic (8.52e-2)" "unprognostic (2.95e-1)" "unprognostic (2.78e-2)" "unprognostic (6.52e-3)" "unprognostic (1.20e-1)" "unprognostic (1.67e-2)" "unprognostic (8.67e-2)" "unprognostic (1.96e-1)" "unprognostic (7.30e-3)" "unprognostic (1.31e-1)" "unprognostic (2.71e-3)" "unprognostic (1.50e-1)" "unprognostic (7.29e-2)" "unprognostic (1.06e-2)" "unprognostic (1.37e-2)" 103.9 1.0 0.7 4.5 17.3 11.5 38.5 1.5 1.9 22.7 0.3 1.9 333.5 13.3 22.5 2.3 1.9 13.4 4.3 0.1 0.6 302.5 56.1 27.6 10.3 9.3 2.3 0.9 1.2 0.5 0.6 73.0 10.9 79.6 3.4 0.1 6.1 44.5 20.3 1.9 289.7 1.5 0.9 7.9 1.6 1.3 4.6 16.6 1.2 23.5 12.3 6.0 7.6 0.4 0.1 0.0 0.9 0.3 280.1 684.4 1.6 160.3 1116.9 82.2 209.8 0.0 0.3 172.9 0.1 130.1 107.4 0.5 5.2 6.1 201.3 0.0 0.8 0.0 0.1 0.2 229.6 0.0 0.0 651.1 1.0 40.4 308.1 89.4 59.5 0.4 0.2 0.3 135.1 0.7 0.4 1.0 6.1 0.5 1.1 303.3 139.9 1.6 5.2 1.9 0.5 1.5 0.1 0.5 31.9 68.3 0.2 0.2 165.8 356.4 0.8 115.7 27.9 0.1 0.0 217.3 42.5 0.1 7.3 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.0 139.4 0.0 0.0 1.1 0.0 0.0 0.7 17.3 1.5 1.9 0.1 0.6 9.3 2.3 10.9 0.9 4.6 0.4 5.9 9.6 13.0 0.3 2.3 0.8 74.1 2.5 0.0 0.0 1.5 64.1 1.6 21.5 11.2 22.0 0.0 82.1 6.9 0.0 9.8 0.2 0.5 6.2 273.3 6.6 0.0 0.0 2.2 0.0 57.8 40.6 0.0 5.7 2.5 0.0 2.9 53.2 8.9 0.0 8.1 9.9 2.0 3.1 1.2 0.5 4.1 10.7 0.0 0.0 0.2 0.0 0.0 0.5 0.3 0.6 13.8 1.2 0.1 40.0 372.4 125.7 1.6 0.0 0.0 17.4 11.1 0.2 0.5 0.1 0.3 126.0 2.5 0.1 12.6 33.6 MMEL1 "MMEL2, NEPII, NL1, NL2, SEP" ENSG00000142606 "Membrane metalloendopeptidase like 1" Q495T6 1 2590639-2633016 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 24.6" "Cell type enhanced" "Detected in many" "Early spermatids: 131.2;Late spermatids: 36.1;Paneth cells: 54.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in some" 5 "SK-BR-3: 14.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA007876, HPA008205, CAB020786" Uncertain "Intracellular and membrane" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 29: Early spermatids - Spermatogenesis" "CAB020786: , HPA007876: AB_1854012, HPA008205: AB_1854011" "unprognostic (5.80e-2)" "unprognostic (4.61e-2)" "unprognostic (1.87e-1)" "unprognostic (4.27e-2)" "unprognostic (1.33e-1)" "unprognostic (2.71e-2)" "unprognostic (1.45e-1)" "unprognostic (7.96e-2)" "unprognostic (1.36e-2)" "unprognostic (2.37e-1)" "unprognostic (4.54e-3)" "unprognostic (2.44e-2)" "unprognostic (4.79e-2)" "unprognostic (3.18e-1)" "unprognostic (2.82e-1)" "unprognostic (2.18e-3)" "unprognostic (7.01e-4)" 2.9 1.4 0.6 0.0 0.6 0.0 3.0 0.5 0.9 3.2 0.4 3.7 2.6 0.7 0.9 4.8 2.9 0.0 0.5 0.5 0.8 3.7 0.5 2.8 0.0 1.0 1.0 0.4 2.0 0.6 0.7 0.0 0.8 6.5 0.3 0.1 1.6 0.3 0.2 0.7 4.2 0.0 0.7 2.5 8.2 24.6 0.7 0.0 1.1 0.0 0.0 3.1 3.2 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 2.3 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.5 0.0 0.1 0.0 14.2 0.0 0.0 1.3 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.0 1.0 4.7 0.3 2.6 0.2 0.4 1.0 0.4 0.7 0.0 2.7 1.3 0.6 1.8 3.6 0.1 4.2 1.7 0.6 0.6 0.5 0.9 0.5 0.8 1.0 1.0 0.8 0.7 0.7 0.6 5.9 0.0 0.0 0.3 0.4 0.0 5.2 5.2 1.2 0.0 10.3 8.9 1.1 20.0 10.2 18.4 0.0 0.0 0.3 12.1 0.0 9.4 131.2 7.1 0.5 2.3 1.2 2.5 0.1 3.4 0.0 1.3 8.6 7.3 0.0 0.0 1.4 0.2 1.2 0.0 0.2 16.5 2.0 1.0 0.2 36.1 1.8 2.4 0.0 0.0 0.9 0.5 0.0 0.5 0.0 4.0 54.9 1.2 0.2 6.7 20.8 0.1 8.8 0.2 0.0 0.0 0.6 0.6 1.1 0.6 0.0 0.0 0.8 0.4 9.7 12.6 MMP1 CLG ENSG00000196611 "Matrix metallopeptidase 1" P03956 11 102789401-102798160 "Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Collagen degradation, Host-virus interaction" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 75.7;stomach 1: 47.6;urinary bladder: 52.2" "Cell type enriched" "Detected in many" 10 "Pancreatic endocrine cells: 2239.5" "Cancer enhanced" "Detected in many" "head and neck cancer: 344.2" "Region enriched" "Detected in single" 7 "cerebral cortex: 1.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ hTERT+: 1139.1;HBF TERT88: 1094.4;HUVEC TERT2: 2954.4;WM-115: 1454.1" "Not detected" "Not detected" HPA004920 Approved Vesicles "Secreted to extracellular matrix" NA NA 7730000 55000 "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 17: WM-115 - Nervous system development" "Cluster 16: Pancreatic endocrine cells - Mixed function" Vesicles "HPA004920: AB_2667293" "unprognostic (4.11e-3)" "prognostic unfavorable (4.66e-4)" "unprognostic (4.20e-3)" "unprognostic (1.19e-3)" "unprognostic (6.46e-2)" "unprognostic (6.50e-2)" "prognostic unfavorable (4.22e-6)" "unprognostic (7.83e-3)" "unprognostic (2.94e-2)" "unprognostic (5.44e-2)" "unprognostic (1.11e-3)" "unprognostic (1.75e-1)" "prognostic unfavorable (9.86e-10)" "unprognostic (1.67e-2)" "unprognostic (1.49e-1)" "unprognostic (1.26e-2)" "unprognostic (5.11e-2)" 0.3 0.1 0.0 26.7 0.0 0.3 0.2 0.0 1.3 0.1 0.0 6.1 7.9 10.7 0.0 4.2 0.1 75.7 0.4 0.0 0.1 1.0 0.8 6.7 0.1 0.0 0.0 0.0 1.8 0.0 0.1 7.2 0.0 0.4 6.8 0.0 6.9 0.2 0.0 0.6 13.0 1.2 0.0 2.1 47.6 0.1 0.1 0.3 0.2 0.0 1.7 52.2 0.2 0.0 0.0 0.0 0.0 1.0 0.0 1.1 0.0 517.1 1139.1 456.6 118.2 9.1 1.0 0.0 5.2 275.5 175.2 4.6 0.0 160.0 1094.4 0.0 1.0 0.0 0.0 0.0 2.9 0.0 0.5 0.3 0.8 470.1 39.6 0.1 2954.4 0.0 1.5 0.5 0.3 0.0 0.0 0.0 0.4 189.3 20.8 0.0 0.1 0.0 0.7 2.2 0.0 0.1 4.8 0.0 1.6 0.1 0.5 0.0 155.0 374.1 0.6 16.8 1.3 0.1 0.0 0.0 8.8 0.0 1454.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.3 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 1.3 3.2 2.6 0.0 0.2 2.3 22.4 90.4 0.0 0.0 0.0 0.0 0.1 30.0 15.8 3.7 0.0 0.0 0.0 0.2 0.0 143.7 0.0 0.1 0.2 113.2 0.0 0.0 0.1 204.8 0.1 11.5 25.5 2.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 2.0 1.9 0.4 0.0 0.0 15.5 0.0 0.0 4.2 0.0 0.0 0.0 0.0 2239.5 1.2 0.0 0.0 30.9 0.7 0.2 1.3 0.0 0.0 1.8 10.5 0.0 0.0 0.0 0.3 0.1 0.1 0.1 0.1 44.3 MMP10 STMY2 ENSG00000166670 "Matrix metallopeptidase 10" P09238 11 102770502-102780628 "Cancer-related genes, Enzymes, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 34 "endometrium 1: 265.4" "Cell type enriched" "Detected in some" 38 "Basal respiratory cells: 3913.2" "Group enriched" "Detected in many" 4 "cervical cancer: 47.8;head and neck cancer: 102.2;lung cancer: 42.3" "Region enhanced" "Detected in single" "thalamus: 1.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ: 11.8;HUVEC TERT2: 15.1;SCLC-21H: 4.7" CAB002159 Uncertain Approved "Plasma membrane,Cytosol" "Secreted to extracellular matrix" NA NA 765000 "Cluster 89: Fibroblasts - ECM organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Cytosol "Plasma membrane" "CAB002159: AB_564103" "unprognostic (8.76e-2)" "unprognostic (3.38e-1)" "unprognostic (1.98e-3)" "unprognostic (2.72e-3)" "unprognostic (7.17e-3)" "unprognostic (1.52e-2)" "unprognostic (5.67e-8)" "unprognostic (2.08e-3)" "unprognostic (2.20e-1)" "unprognostic (1.75e-1)" "unprognostic (1.67e-2)" "unprognostic (2.67e-1)" "unprognostic (6.99e-5)" "unprognostic (2.66e-2)" "unprognostic (7.98e-2)" "unprognostic (5.46e-2)" "prognostic favorable (7.12e-4)" 0.1 0.0 0.1 7.7 0.0 0.1 0.1 0.0 0.8 1.2 0.0 0.4 1.1 265.4 0.0 0.2 0.0 1.3 0.0 0.2 0.3 0.1 1.0 2.0 0.1 0.1 0.3 0.2 0.2 0.0 0.0 1.3 0.3 1.4 0.2 0.0 1.6 0.0 0.0 0.1 0.8 0.2 0.0 0.0 2.9 0.5 1.9 0.6 0.0 0.2 0.7 4.4 3.2 0.0 0.0 0.1 0.8 0.2 0.0 0.0 0.2 11.8 0.6 0.1 0.1 0.3 0.0 0.0 3.3 1.8 0.2 2.7 0.0 1.3 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.4 0.5 0.0 15.1 0.0 0.7 0.0 0.0 0.0 0.0 0.3 2.8 0.5 1.6 0.0 0.0 0.0 0.0 0.6 4.7 0.0 2.4 0.0 0.0 0.8 0.0 0.0 1.9 3.5 1.2 0.4 0.5 0.0 0.0 0.1 0.6 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.8 0.2 0.3 0.1 0.3 0.3 0.0 1.9 0.0 0.1 0.0 0.0 0.0 0.0 0.8 51.3 3913.2 0.0 0.0 0.7 0.0 0.1 0.0 85.4 29.5 0.0 0.0 0.0 0.4 0.0 34.0 6.1 6.4 2.5 9.0 0.0 0.0 0.0 14.6 0.0 6.3 0.0 12.4 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 22.4 0.0 9.5 1.3 0.0 0.6 0.0 0.0 1.6 0.0 0.0 0.0 0.0 102.5 0.1 0.0 0.0 42.5 0.0 0.1 29.3 0.0 0.0 0.0 11.7 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.1 8.2 MMP11 STMY3 ENSG00000099953 "Matrix metallopeptidase 11" P24347 22 23768226-23784316 "Cancer-related genes, Enzymes, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "cervix: 64.8;endometrium 1: 142.8;placenta: 39.6" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 84.9;Extravillous trophoblasts: 37.6;Granulosa cells: 61.9;Smooth muscle cells: 35.8" "Cancer enhanced" "Detected in all" "pancreatic cancer: 119.1" "Low region specificity" "Detected in single" "Immune cell enriched" "Detected in single" 5 "plasmacytoid DC: 4.4" "Lineage enriched" "Detected in single" 5 "dendritic cells: 4.4" "Cell line enhanced" "Detected in many" "AN3-CA: 38.4;hTERT-RPE1: 19.7;REH: 16.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB002593, HPA055204, HPA068864" Approved Approved "Golgi apparatus,Cytosol" "Secreted to extracellular matrix" NA NA 640000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 36: Stromal cells - Cell proliferation" "Golgi apparatus" Cytosol "CAB002593: , HPA055204: , HPA068864: AB_2686051" "unprognostic (1.06e-1)" "unprognostic (3.08e-1)" "unprognostic (1.83e-1)" "unprognostic (1.84e-3)" "unprognostic (2.77e-2)" "unprognostic (6.73e-2)" "unprognostic (2.14e-2)" "unprognostic (5.15e-1)" "unprognostic (2.73e-2)" "unprognostic (2.20e-1)" "unprognostic (1.89e-3)" "unprognostic (7.04e-2)" "prognostic unfavorable (2.62e-4)" "unprognostic (8.05e-2)" "unprognostic (6.78e-2)" "unprognostic (1.10e-1)" "unprognostic (1.68e-2)" 3.3 1.6 0.4 1.4 0.3 0.5 2.2 0.3 1.2 64.8 0.3 3.9 6.8 142.8 0.1 1.0 5.7 6.8 7.2 0.3 0.4 2.5 0.6 1.4 3.9 0.4 0.4 12.5 1.3 3.3 0.5 39.6 0.4 1.9 3.5 0.0 5.3 1.5 0.9 3.8 6.0 9.4 0.4 1.4 2.6 6.7 0.4 3.1 1.3 0.9 1.7 2.9 3.6 0.4 0.3 0.0 4.8 38.4 5.7 8.3 0.1 0.6 10.4 1.3 0.8 0.4 1.3 1.3 5.1 2.8 1.8 0.2 2.2 0.0 0.4 0.0 0.8 0.0 0.0 2.2 4.2 0.0 0.0 5.4 0.9 1.1 0.1 19.7 6.0 0.4 0.6 0.0 1.4 0.3 0.1 0.1 1.4 1.2 0.2 16.6 0.0 0.4 0.7 0.0 6.0 10.3 3.9 0.6 0.0 5.9 3.6 0.0 2.7 0.6 0.0 1.6 0.1 0.1 0.2 5.0 0.3 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.7 0.1 0.0 0.0 0.0 0.0 4.4 0.0 0.1 0.4 0.3 0.3 1.2 0.3 0.4 0.4 0.4 0.4 0.4 0.4 0.4 1.2 0.0 2.5 0.3 3.4 1.0 0.8 0.8 0.6 0.4 1.9 0.5 6.1 1.5 0.1 0.0 0.0 0.7 1.8 0.4 1.9 8.6 10.3 4.4 84.9 0.9 1.8 0.0 0.2 0.7 37.6 8.4 1.5 4.1 1.3 61.9 1.1 0.0 0.8 0.0 0.4 1.3 2.0 0.0 1.1 10.5 0.6 1.0 1.8 1.0 0.0 0.3 0.0 0.0 0.2 1.4 0.2 0.4 0.2 0.5 0.1 2.2 0.8 0.5 0.0 2.7 35.8 3.1 5.5 0.5 0.6 18.6 2.0 5.7 1.0 0.3 MMP12 HME ENSG00000262406 "Matrix metallopeptidase 12" P39900 11 102862736-102874982 "Cancer-related genes, Enzymes, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 15.7;lymphoid tissue: 40.4;urinary bladder: 16.0" "Cell type enriched" "Detected in some" 9 "Extravillous trophoblasts: 303.4" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 13 "BJ: 3.3;fHDF/TERT166: 11.4;hTEC/SVTERT24-B: 6.3" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted to extracellular matrix" NA NA "Cluster 14: B-cells - Humoral immune response" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 38: Extravillous trophoblasts - Unknown function" "unprognostic (7.33e-2)" "unprognostic (3.20e-2)" "unprognostic (1.00e-2)" "unprognostic (1.03e-1)" "unprognostic (2.74e-1)" "unprognostic (1.67e-1)" "prognostic unfavorable (1.42e-4)" "unprognostic (1.69e-2)" "unprognostic (7.31e-2)" "unprognostic (1.52e-2)" "unprognostic (1.52e-3)" "unprognostic (5.45e-2)" "unprognostic (3.05e-6)" "unprognostic (1.08e-2)" "unprognostic (4.66e-2)" "unprognostic (1.73e-1)" "unprognostic (6.92e-2)" 0.5 0.0 0.0 40.4 0.1 0.0 0.4 0.0 0.0 0.1 0.0 13.5 6.8 0.6 0.0 0.4 0.0 2.6 0.0 0.0 0.3 0.9 0.1 0.6 7.0 0.1 0.1 0.0 0.1 0.0 0.0 7.4 0.1 1.3 15.7 0.0 2.4 0.0 0.0 0.5 7.8 2.2 0.1 3.7 3.5 0.0 0.1 3.9 0.0 0.0 19.4 16.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 0.3 0.1 0.0 0.0 0.0 0.0 0.0 11.4 0.1 0.4 0.0 0.0 0.3 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.4 0.4 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 3.2 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 1.1 0.0 0.0 0.1 0.7 0.0 0.0 0.0 18.6 303.4 0.4 0.0 0.2 0.0 0.0 0.0 0.0 15.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 32.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.5 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 4.5 0.1 0.0 0.0 2.2 MMP13 CLG3 ENSG00000137745 "Matrix metallopeptidase 13" P45452 11 102942995-102955732 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 12 "urinary bladder: 12.9" "Cell type enriched" "Detected in some" 12 "Basal respiratory cells: 426.0" "Cancer enhanced" "Detected in many" "head and neck cancer: 70.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "HaCaT: 17.9;PC-3: 6.7" "Not detected" "Not detected" "Not detected" "Not detected" CAB002742 Supported "Secreted to extracellular matrix" NA NA "Cluster 11: Basophils - Unknown function" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "CAB002742: " "unprognostic (8.98e-3)" "unprognostic (1.54e-1)" "unprognostic (4.75e-2)" "unprognostic (4.57e-2)" "unprognostic (3.05e-2)" "unprognostic (1.59e-3)" "unprognostic (1.32e-1)" "unprognostic (6.35e-3)" "unprognostic (1.69e-1)" "unprognostic (7.55e-3)" "unprognostic (2.24e-1)" "unprognostic (1.73e-8)" "unprognostic (2.12e-2)" "unprognostic (3.14e-1)" "unprognostic (4.14e-2)" "unprognostic (4.33e-2)" 0.1 0.0 0.0 0.2 0.1 0.4 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.0 0.0 0.2 0.1 0.0 0.0 0.0 0.5 0.0 0.2 0.2 0.0 0.0 0.1 0.0 0.1 0.2 0.1 0.0 0.1 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 12.9 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 17.9 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.5 0.1 0.0 0.0 0.0 6.7 0.0 0.0 0.1 0.0 1.8 0.0 0.0 0.1 2.0 0.0 0.0 0.0 0.0 0.0 2.4 1.3 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.3 0.3 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.2 0.2 0.1 0.2 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 8.7 426.0 0.0 0.0 0.0 0.0 0.2 0.0 33.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 6.8 0.0 0.0 0.0 2.2 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 15.8 MMP14 MT1-MMP ENSG00000157227 "Matrix metallopeptidase 14" P50281 14 22836560-22849041 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 244.0;Pancreatic endocrine cells: 144.7;Syncytiotrophoblasts: 122.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 923.8;HHSteC: 794.2;HSkMC: 887.0;hTERT-RPE1: 925.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009918, HPA051432" Approved Approved "Intermediate filaments,Cytosol" No No 1400000 "Cluster 46: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 38: Extravillous trophoblasts - Unknown function" Cytosol "Intermediate filaments" "CAB009918: AB_2250767, HPA051432: AB_2681484" "unprognostic (1.34e-1)" "unprognostic (1.37e-1)" "unprognostic (1.11e-2)" "unprognostic (2.81e-1)" "unprognostic (4.28e-2)" "unprognostic (1.12e-2)" "unprognostic (3.05e-3)" "unprognostic (5.91e-3)" "unprognostic (1.95e-1)" "prognostic unfavorable (9.48e-4)" "unprognostic (3.82e-3)" "unprognostic (7.31e-2)" "prognostic unfavorable (1.34e-4)" "unprognostic (5.02e-2)" "unprognostic (6.69e-2)" "unprognostic (1.00e-2)" "unprognostic (3.41e-3)" 151.5 31.7 5.6 59.9 5.0 1.6 101.5 5.7 7.5 181.3 61.8 77.2 39.5 167.3 19.0 92.1 82.1 148.2 41.3 6.6 7.2 35.9 13.2 91.8 24.8 11.9 8.4 90.2 36.0 65.3 14.2 118.9 9.2 59.9 36.6 9.6 78.1 45.5 18.8 127.5 69.4 106.0 7.3 30.8 57.7 11.7 13.2 13.0 50.0 16.1 30.8 103.9 111.1 10.6 90.6 1.2 26.3 2.0 923.8 651.6 455.9 270.1 606.4 93.3 158.5 21.3 337.4 0.9 146.4 301.9 24.6 216.3 0.3 262.2 99.7 1.1 0.6 37.2 1.7 5.0 794.2 0.4 1.3 887.0 148.7 334.7 288.3 925.5 492.9 0.6 0.8 2.1 185.1 0.7 0.4 79.4 14.7 17.7 52.4 2.1 96.0 0.2 61.4 148.1 0.3 0.6 187.3 0.3 574.2 104.4 1.0 79.5 436.8 724.9 53.7 198.2 329.6 0.8 1.6 1.1 410.9 0.6 396.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.6 5.0 5.7 7.5 6.6 7.2 11.9 8.4 9.2 7.3 13.2 10.6 13.9 12.8 3.0 2.0 3.4 34.0 23.4 105.4 39.3 0.0 14.1 17.5 4.7 50.1 42.2 7.3 0.0 105.6 0.3 19.9 11.7 63.0 0.4 16.1 81.6 35.2 7.8 0.0 0.0 28.7 244.0 84.0 25.5 14.8 3.8 9.3 32.9 2.7 89.5 0.0 0.0 24.5 34.6 20.2 32.7 2.4 72.1 38.0 37.4 4.7 21.5 14.3 0.0 0.5 0.1 144.7 33.0 54.9 0.3 21.8 19.9 11.7 46.8 0.8 39.5 11.1 73.9 0.8 0.8 33.7 34.2 122.7 2.5 15.6 18.6 37.9 MMP15 "MT2-MMP, MTMMP2, SMCP-2" ENSG00000102996 "Matrix metallopeptidase 15" P51511 16 58025754-58046901 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cholangiocytes: 55.8;Distal enterocytes: 109.3;Proximal enterocytes: 67.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 93.6;Hep G2: 51.1;OE19: 44.6;SK-BR-3: 47.3;WM-115: 78.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002611, HPA040390" Uncertain Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 28: BEWO - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane, Cytosol" Nucleoplasm "CAB002611: , HPA040390: AB_2676956" "unprognostic (1.76e-2)" "unprognostic (7.32e-2)" "unprognostic (2.69e-1)" "unprognostic (6.85e-2)" "unprognostic (3.09e-1)" "unprognostic (1.68e-1)" "unprognostic (6.88e-3)" "unprognostic (1.40e-1)" "unprognostic (3.02e-2)" "unprognostic (1.24e-2)" "unprognostic (4.81e-2)" "unprognostic (1.81e-1)" "prognostic favorable (8.54e-8)" "unprognostic (3.63e-2)" "unprognostic (1.36e-1)" "unprognostic (1.28e-1)" "prognostic favorable (3.08e-4)" 11.9 3.8 8.9 4.4 6.0 0.4 7.6 7.3 11.2 5.7 5.8 28.0 40.2 3.5 1.1 4.6 6.1 14.3 41.2 6.9 8.7 14.9 50.1 9.9 2.1 15.8 10.6 1.1 18.5 12.7 8.8 28.4 16.8 4.4 14.3 1.5 8.4 9.5 7.0 4.3 33.0 3.7 5.8 9.3 29.6 34.9 18.7 1.0 46.7 5.6 1.3 5.1 2.8 8.6 15.3 11.4 5.8 30.4 6.0 0.3 93.6 1.4 0.8 5.4 1.2 9.1 38.3 0.2 17.7 1.6 4.2 21.0 5.1 4.4 1.6 0.1 10.0 0.1 4.9 51.1 7.7 0.3 19.5 3.1 7.8 0.9 2.3 8.4 3.7 8.5 12.9 0.1 1.8 7.6 0.7 2.6 17.2 44.6 3.2 7.6 0.7 8.3 16.6 5.4 1.6 10.4 20.0 47.3 9.5 13.2 5.2 8.2 3.4 0.4 9.1 3.5 1.3 0.2 0.1 0.3 1.9 2.3 78.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 8.9 6.0 7.3 11.2 6.9 8.7 15.8 10.6 16.8 5.8 18.7 8.6 14.3 19.2 14.4 9.1 0.7 2.5 1.0 4.9 2.8 3.4 5.0 3.0 24.7 55.8 12.6 18.4 16.7 48.2 1.6 109.3 1.9 35.7 5.0 3.6 1.1 17.2 11.4 2.7 1.4 12.0 49.2 4.5 35.2 6.4 0.0 18.6 13.6 39.2 12.9 1.7 1.2 33.3 10.2 3.0 0.3 6.9 0.9 0.9 1.8 1.0 0.0 2.1 0.0 4.5 1.4 13.3 38.5 3.4 0.3 1.3 67.3 7.3 6.0 1.9 0.0 0.7 2.4 0.9 4.6 3.3 2.3 48.4 0.7 23.2 45.0 1.7 MMP16 "C8orf57, DKFZp761D112, MT3-MMP" ENSG00000156103 "Matrix metallopeptidase 16" P51512 8 88032011-88328025 "Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 5.8" "Cell type enriched" "Detected in many" 5 "Oligodendrocyte precursor cells: 2402.1" "Cancer enhanced" "Detected in many" "glioma: 4.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AN3-CA: 29.4;HUVEC TERT2: 12.8;SH-SY5Y: 16.2;U-138 MG: 13.7;WM-115: 28.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA023693 Uncertain Approved Vesicles,Cytosol "Secreted to extracellular matrix" NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 17: WM-115 - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol Vesicles "HPA023693: AB_1854025" "unprognostic (2.58e-1)" "unprognostic (2.42e-2)" "unprognostic (1.38e-1)" "unprognostic (1.87e-1)" "unprognostic (7.09e-2)" "unprognostic (3.31e-2)" "unprognostic (2.39e-3)" "unprognostic (1.45e-3)" "unprognostic (2.46e-1)" "unprognostic (2.61e-1)" "unprognostic (9.42e-2)" "unprognostic (2.92e-1)" "unprognostic (2.09e-8)" "unprognostic (6.90e-3)" "unprognostic (1.16e-1)" "unprognostic (3.62e-1)" "unprognostic (2.19e-3)" 0.7 0.3 4.6 0.3 5.8 0.0 1.8 2.2 5.4 1.7 0.0 0.8 0.1 1.6 0.6 0.4 0.6 2.6 0.8 5.1 3.9 0.1 0.1 0.2 0.2 1.0 1.5 1.0 0.6 0.2 0.5 1.0 1.3 0.9 0.4 0.4 0.3 0.7 0.1 0.2 0.3 1.3 1.4 0.4 0.3 0.4 3.0 0.4 1.0 0.5 0.2 0.9 0.5 3.3 0.0 0.2 7.9 29.4 1.0 2.0 0.0 10.9 1.6 3.0 1.8 0.0 0.1 0.0 0.0 4.9 1.8 0.0 5.8 0.0 3.7 0.0 3.4 0.0 0.0 0.0 2.4 0.0 0.5 1.4 0.0 4.4 1.3 5.4 12.8 0.1 0.0 1.1 1.7 0.0 0.0 0.0 1.7 0.0 3.0 0.3 0.6 0.0 0.6 0.1 0.2 16.2 0.0 0.0 0.2 2.2 1.1 0.0 7.1 13.7 7.7 0.2 4.2 0.0 0.0 0.0 5.7 0.0 28.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.6 5.8 2.2 5.4 5.1 3.9 1.0 1.5 1.3 1.4 3.0 3.3 2.2 0.0 0.0 20.5 0.1 1.1 0.0 0.0 0.6 4.4 0.8 1.4 1.0 0.0 0.0 0.0 2.1 0.1 0.1 0.0 1.9 0.0 6.5 0.5 15.9 5.2 0.0 0.0 443.4 0.0 0.1 16.0 0.0 0.4 0.0 1.9 1.4 0.0 0.4 1.7 300.3 0.0 0.0 0.0 1.6 6.5 0.9 0.4 1.8 10.3 0.0 3.0 0.0 2402.1 13.0 0.1 0.0 1.2 0.0 0.1 0.0 0.1 0.0 0.6 0.0 0.7 2.9 0.0 1.1 0.2 0.1 0.0 0.2 3.4 0.0 0.1 MMP17 MT4-MMP ENSG00000198598 "Matrix metallopeptidase 17" Q9ULZ9 12 131828393-131851783 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 37.2" "Group enriched" "Detected in many" 5 "Excitatory neurons: 47.0;Inhibitory neurons: 14.3;Melanocytes: 28.4;Oligodendrocyte precursor cells: 26.7" "Cancer enriched" "Detected in many" 10 "melanoma: 29.9" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 5 "REH: 29.6;SK-MEL-30: 60.4;WM-115: 87.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "Secreted to extracellular matrix" NA NA "Cluster 37: B-cells - Transcription" "Cluster 10: Brain - Neuronal signaling" "Cluster 17: WM-115 - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "unprognostic (9.11e-2)" "unprognostic (1.27e-2)" "unprognostic (1.69e-2)" "unprognostic (3.71e-3)" "unprognostic (5.62e-2)" "unprognostic (1.85e-2)" "unprognostic (8.90e-3)" "unprognostic (2.14e-2)" "unprognostic (2.60e-1)" "unprognostic (2.66e-4)" "unprognostic (7.68e-2)" "unprognostic (5.88e-2)" "unprognostic (9.26e-10)" "unprognostic (1.15e-2)" "unprognostic (2.65e-1)" "unprognostic (1.21e-3)" "unprognostic (2.81e-2)" 3.9 0.8 9.9 1.2 16.6 0.9 4.0 0.0 37.2 10.8 0.0 6.4 0.3 3.7 0.0 1.7 2.4 1.0 2.2 31.7 9.2 1.0 1.0 2.0 0.9 0.0 0.2 11.6 2.0 0.1 1.5 0.1 0.3 2.9 0.1 0.1 3.1 0.5 0.9 4.7 2.7 0.3 0.0 1.7 1.6 3.2 6.3 0.0 1.7 0.0 0.2 2.7 4.7 8.8 0.3 11.5 0.0 0.5 2.3 2.9 0.1 7.2 7.9 2.1 3.3 0.0 1.4 0.0 5.2 1.8 1.4 3.8 1.3 1.5 0.0 0.0 0.7 1.1 3.8 0.0 3.6 0.0 7.2 2.7 1.2 2.4 0.0 0.5 4.0 0.0 2.0 0.0 1.0 8.3 0.0 11.5 4.6 1.6 7.3 29.6 0.0 3.9 0.0 0.0 3.7 2.0 1.0 0.2 60.4 0.5 7.4 12.8 5.8 0.7 0.9 6.3 0.6 0.0 0.0 0.0 2.4 0.3 87.5 0.0 0.4 0.0 0.0 0.4 0.0 0.5 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.1 9.9 16.6 0.0 37.2 31.7 9.2 0.0 0.2 0.3 0.0 6.3 8.8 0.6 0.0 0.0 2.9 2.3 2.5 0.1 1.7 0.6 1.0 2.3 1.8 1.2 1.5 0.9 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 5.4 0.5 0.0 0.0 47.0 0.2 0.2 5.4 0.0 0.4 0.0 0.7 1.1 0.0 0.6 3.3 14.3 0.0 2.0 2.6 1.0 0.4 0.9 3.4 28.4 3.7 2.4 0.1 0.0 26.7 2.9 0.0 0.0 1.9 0.0 0.2 0.0 0.4 0.2 0.1 0.0 0.8 1.4 0.4 0.4 0.1 1.1 0.0 0.2 5.3 0.0 0.2 MMP19 "MMP18, RASI-1" ENSG00000123342 "Matrix metallopeptidase 19" Q99542 12 55835433-55842966 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted secreted proteins" "Angiogenesis, Collagen degradation, Differentiation" "Developmental protein, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 58.5" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 54.4;Fibroblasts: 52.8;Hofbauer cells: 30.8;Kupffer cells: 35.7;Langerhans cells: 100.7;Macrophages: 61.2" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in single" "thalamus: 1.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in many" 5 "BEWO: 75.6" "Region enriched" "Detected in many" 5 "olfactory bulb: 7.2" "Low region specificity" "Detected in all" HPA070804 Approved "Endoplasmic reticulum,Vesicles" "Secreted to extracellular matrix" NA NA 2100000 "Cluster 82: Adipose tissue - ECM organization" "Cluster 28: BEWO - Transcription regulation" "Cluster 41: Macrophages - Immune response" "Endoplasmic reticulum, Vesicles" "HPA070804: AB_2686315" "unprognostic (2.61e-1)" "unprognostic (6.56e-2)" "unprognostic (2.28e-2)" "unprognostic (2.42e-1)" "unprognostic (4.77e-3)" "unprognostic (4.77e-3)" "unprognostic (2.01e-2)" "unprognostic (4.03e-2)" "unprognostic (2.85e-2)" "unprognostic (4.30e-2)" "unprognostic (2.37e-1)" "unprognostic (2.09e-1)" "prognostic unfavorable (8.56e-9)" "unprognostic (5.06e-3)" "unprognostic (1.28e-3)" "unprognostic (2.73e-2)" "unprognostic (4.00e-2)" 58.5 3.6 0.0 11.4 0.1 0.7 18.3 0.0 0.3 10.4 0.5 7.3 1.2 20.7 0.5 2.3 17.2 25.6 8.8 0.1 0.1 5.7 2.7 25.4 2.8 0.1 0.1 11.9 7.2 0.5 0.8 10.8 0.2 3.3 3.3 0.1 3.1 2.3 0.9 5.5 8.7 8.7 0.1 27.4 9.6 0.4 1.3 2.9 4.4 0.6 6.9 9.6 6.2 0.1 1.5 0.0 0.2 0.0 7.8 12.4 75.6 10.1 10.6 3.9 4.4 0.6 0.6 0.0 0.0 12.8 0.3 0.0 0.0 3.0 4.0 0.8 0.0 0.0 0.3 0.1 6.5 0.0 0.6 12.1 0.4 1.9 2.4 6.2 0.7 0.0 0.2 0.1 11.2 0.0 0.0 0.2 0.3 0.0 0.2 0.0 2.8 0.0 1.7 4.7 0.0 0.0 0.2 0.0 0.0 1.4 0.0 0.2 15.7 2.2 5.0 0.2 0.3 0.1 0.0 0.0 8.4 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.3 0.1 0.1 0.1 0.1 0.2 0.1 1.3 0.1 2.8 0.0 4.6 0.7 1.3 7.1 0.3 1.9 0.6 0.4 0.3 0.3 0.7 11.5 3.3 0.0 4.2 18.6 0.7 0.0 0.0 0.3 0.5 2.4 20.8 1.5 0.0 0.0 0.2 0.5 54.4 52.8 1.1 1.7 2.5 0.4 3.6 0.7 30.8 0.0 0.2 0.1 0.0 35.7 100.7 0.9 5.9 61.2 12.4 1.9 22.5 0.4 0.0 0.0 0.3 0.1 0.0 5.3 1.0 0.3 0.0 0.1 1.5 1.7 0.0 3.8 7.6 0.2 0.2 1.0 4.3 18.7 0.9 0.2 0.0 0.4 MMP2 "CLG4, CLG4A, TBE-1" ENSG00000087245 "Matrix metallopeptidase 2" P08253 16 55389700-55506691 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Angiogenesis, Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "gallbladder: 1062.9" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 222.4;Extravillous trophoblasts: 467.9;Fibroblasts: 815.9;Leydig cells: 340.2;Peritubular cells: 419.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 5619.3;ASC TERT1: 1623.2;hTERT-RPE1: 6400.4;U-87 MG: 1812.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA001939, CAB002788" Approved Approved Vesicles "Secreted to extracellular matrix" NA NA 1600000000 220000000 "Cluster 46: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" Vesicles "CAB002788: , HPA001939: AB_1079395" "unprognostic (7.26e-2)" "unprognostic (1.36e-3)" "unprognostic (1.66e-1)" "unprognostic (2.14e-3)" "unprognostic (5.03e-2)" "unprognostic (1.20e-1)" "unprognostic (1.74e-1)" "unprognostic (9.36e-3)" "unprognostic (4.81e-3)" "unprognostic (3.79e-2)" "unprognostic (4.59e-3)" "unprognostic (6.12e-2)" "unprognostic (1.28e-3)" "unprognostic (1.59e-2)" "unprognostic (8.00e-2)" "unprognostic (8.98e-2)" "unprognostic (4.63e-2)" 518.9 68.3 3.9 135.1 4.0 1.2 328.9 4.9 7.8 514.1 9.4 173.8 57.4 453.6 192.6 121.5 190.6 1062.9 212.8 3.6 5.3 43.7 15.6 279.7 28.1 7.6 4.9 271.1 42.8 13.8 14.7 225.0 5.4 116.8 171.3 11.4 124.1 137.5 60.8 455.6 177.3 468.5 6.7 58.3 134.0 49.6 8.6 19.8 113.5 66.1 30.3 660.8 238.1 10.0 6.5 3.9 192.0 2.4 5619.3 1623.2 312.7 501.4 1146.1 99.4 79.0 0.2 2.1 0.5 391.7 891.0 37.0 54.2 1.2 4.6 57.0 0.7 0.9 0.7 12.9 3.0 530.6 0.4 14.8 1396.8 1.7 512.4 4.4 6400.4 651.1 0.5 0.7 2.4 334.7 0.0 0.4 8.2 152.4 0.5 1.6 0.4 46.1 0.9 16.1 7.6 3.2 345.0 93.3 0.8 2.1 849.0 1.6 36.0 924.6 1546.0 144.9 300.5 66.9 1.0 0.6 2.2 1812.3 28.3 289.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.9 4.0 4.9 7.8 3.6 5.3 7.6 4.9 5.4 6.7 8.6 10.0 38.4 0.0 0.5 0.0 0.0 122.1 14.1 48.8 9.1 30.5 3.1 16.8 4.4 0.0 3.1 11.0 0.0 5.6 0.5 0.1 0.0 2.5 12.5 7.7 222.4 46.9 28.2 0.0 0.0 0.4 467.9 815.9 12.2 5.4 0.0 0.0 13.2 0.1 28.2 1.7 0.2 0.1 2.0 1.6 180.7 40.2 340.2 11.8 128.1 27.2 0.0 7.7 0.0 5.0 0.0 9.3 0.0 419.0 2.8 5.6 0.0 0.2 1.1 2.5 13.1 80.0 65.3 1.2 2.8 6.6 102.3 17.2 10.3 35.2 0.0 4.4 MMP20 ENSG00000137674 "Matrix metallopeptidase 20" O60882 11 102576832-102625332 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Amelogenesis imperfecta" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Cell type enriched" "Detected in some" 7 "Early spermatids: 91.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 7 "OE19: 2.5" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted to extracellular matrix" NA NA "Cluster 21: OE19 - Mitochondria" "Cluster 23: Spermatids - Flagellum & Golgi organization" "unprognostic (4.62e-3)" "unprognostic (2.61e-2)" "unprognostic (1.68e-3)" "unprognostic (1.75e-1)" "unprognostic (2.13e-1)" "unprognostic (3.06e-1)" "unprognostic (2.97e-2)" "unprognostic (6.75e-2)" "unprognostic (9.58e-5)" "unprognostic (6.10e-2)" "unprognostic (2.35e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 91.8 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 12.0 0.3 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.4 0.0 0.0 0.4 0.0 0.0 0.0 0.6 0.0 0.0 6.6 0.0 0.0 0.0 0.4 0.0 0.0 0.5 0.0 0.0 0.0 0.4 MMP21 ENSG00000154485 "Matrix metallopeptidase 21" Q8N119 10 125753580-125775821 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" Heterotaxy "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enriched" "Detected in some" 14 "epididymis: 53.9" "Cell type enhanced" "Detected in some" "Distal tubular cells: 1.9;Granulosa cells: 1.4;Microglial cells: 1.9" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted to extracellular matrix" NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 40: Granulosa cells - Unknown function" "unprognostic (1.32e-2)" "unprognostic (1.28e-1)" "unprognostic (8.51e-2)" "unprognostic (2.19e-2)" "unprognostic (4.02e-2)" "unprognostic (2.21e-2)" "unprognostic (4.22e-3)" "unprognostic (1.01e-1)" "unprognostic (2.12e-1)" "unprognostic (1.48e-1)" "unprognostic (2.89e-2)" "unprognostic (3.62e-2)" "unprognostic (9.70e-8)" "unprognostic (1.30e-2)" "unprognostic (7.69e-2)" "unprognostic (7.00e-2)" "unprognostic (2.18e-1)" 0.2 0.3 0.4 0.6 0.7 0.7 0.2 1.7 0.7 0.2 0.2 0.2 0.5 0.5 53.9 0.5 0.4 0.7 0.8 0.5 0.4 0.1 0.3 0.2 1.0 0.3 0.3 3.7 0.7 0.0 0.1 0.1 0.2 0.5 0.1 1.8 1.2 0.2 0.3 1.2 0.4 0.2 0.1 0.6 0.4 1.0 0.5 0.0 0.5 0.0 0.2 0.2 0.0 0.9 0.4 0.2 0.6 0.4 0.1 0.0 0.6 0.4 0.0 0.0 0.0 0.4 0.0 0.5 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.2 0.4 0.1 0.9 0.4 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.1 0.3 0.0 0.2 0.2 0.3 0.3 0.0 0.3 0.2 0.1 0.1 0.0 0.3 0.1 0.2 0.2 0.0 0.0 0.2 0.1 0.1 0.2 0.5 0.2 0.2 0.3 0.5 0.4 0.2 0.1 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.7 1.7 0.7 0.5 0.4 0.3 0.3 0.2 0.1 0.5 0.9 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.1 0.0 1.4 0.0 0.0 0.1 0.0 0.8 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.9 0.0 0.5 0.0 0.5 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.1 0.3 0.1 0.4 0.0 0.0 0.0 0.0 0.2 0.1 0.0 MMP23B "MIFR, MIFR-1, MMP22" ENSG00000189409 "Matrix metallopeptidase 23B" O75900 1 1632163-1635263 "Enzymes, Predicted intracellular proteins, Transporters" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "ovary: 29.9" "Cell type enhanced" "Detected in many" "Fibroblasts: 90.5;Leydig cells: 98.2;NK-cells: 64.9;Peritubular cells: 177.9" "Cancer enhanced" "Detected in single" "ovarian cancer: 0.8" "Low region specificity" "Detected in single" "Immune cell enriched" "Detected in some" 5 "plasmacytoid DC: 11.3" "Lineage enriched" "Detected in many" 5 "dendritic cells: 11.3" "Cell line enhanced" "Detected in some" "HHSteC: 4.4;NTERA-2: 2.7;PC-3: 1.9;U-266/70: 3.9" "Region enriched" "Detected in some" 5 "cerebellum: 7.8" "Low region specificity" "Detected in some" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 89: Fibroblasts - ECM organization" "Cluster 29: U-266 - Adaptive immune response" "Cluster 33: Fibroblasts - ECM organization" "unprognostic (2.19e-2)" "unprognostic (6.31e-2)" "unprognostic (6.70e-3)" "unprognostic (1.29e-1)" "unprognostic (3.99e-2)" "unprognostic (9.31e-2)" "unprognostic (6.94e-2)" "unprognostic (1.20e-1)" "unprognostic (8.06e-2)" "unprognostic (8.37e-2)" "unprognostic (2.22e-1)" "unprognostic (2.33e-1)" "unprognostic (2.26e-11)" "unprognostic (1.60e-3)" "unprognostic (1.36e-1)" "unprognostic (2.44e-2)" "unprognostic (6.66e-2)" 7.1 2.8 0.4 0.3 0.5 1.3 4.1 0.1 1.0 16.7 0.0 5.0 1.9 15.4 0.0 2.8 11.0 2.9 15.0 0.3 0.0 3.2 3.3 14.3 1.1 0.4 0.0 29.9 1.6 0.0 5.7 2.8 0.1 11.8 0.1 0.1 1.0 1.1 0.5 3.1 3.4 1.2 0.0 3.0 4.3 5.2 0.1 0.0 2.4 0.0 0.1 11.9 10.9 0.2 0.6 0.0 0.0 1.8 0.0 0.0 0.8 0.0 0.0 0.1 0.0 0.4 0.5 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.7 0.5 0.2 1.2 4.4 0.2 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.1 0.0 0.4 0.0 0.2 2.7 0.0 1.9 0.9 0.0 1.1 0.0 0.0 0.4 0.2 0.3 0.0 0.1 0.0 0.5 0.0 0.4 0.2 0.1 0.3 0.0 3.9 0.2 1.1 0.0 0.2 0.1 0.0 0.2 0.0 1.5 0.0 0.9 0.0 0.3 1.0 0.0 0.1 0.0 0.7 0.1 2.2 0.1 11.3 0.3 1.7 0.4 0.5 0.1 1.0 0.3 0.0 0.4 0.0 0.1 0.0 0.1 0.2 2.2 0.0 0.5 1.0 1.1 13.4 0.8 0.7 0.6 1.3 1.7 1.5 9.6 1.5 0.4 1.8 0.0 4.0 27.4 3.0 0.0 1.2 1.0 4.0 3.5 2.2 3.0 2.7 0.3 0.5 2.2 90.5 4.6 1.0 0.0 1.4 12.1 1.0 5.7 3.3 0.6 1.9 4.1 1.0 18.5 6.2 98.2 1.3 19.6 0.0 1.2 0.5 64.9 0.0 0.2 4.3 0.9 177.9 4.3 0.5 2.7 1.0 0.5 7.7 0.0 0.7 5.3 2.1 10.5 0.7 15.8 10.3 8.1 2.1 1.7 0.9 MMP24 MT5-MMP ENSG00000125966 "Matrix metallopeptidase 24" Q9Y5R2 20 35226690-35276998 "Enzymes, Predicted membrane proteins, Predicted secreted proteins" "Cell adhesion" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "brain: 40.0" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 16.0;Excitatory neurons: 24.6;Horizontal cells: 15.2;Inhibitory neurons: 38.4;Oligodendrocyte precursor cells: 12.5;Oligodendrocytes: 12.0;Proximal tubular cells: 11.4" "Cancer enhanced" "Detected in many" "renal cancer: 11.4;testis cancer: 10.8" "Region enriched" "Detected in all" 5 "cerebellum: 40.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 36.3;CACO-2: 56.0;EFO-21: 15.8;RPTEC TERT1: 24.6;U-2 OS: 17.7" "Low region specificity" "Detected in all" "Region enriched" "Detected in all" 5 "cerebellum: 51.5" "HPA049280, HPA078816" Approved Approved "Nucleoli,Plasma membrane" "Secreted to extracellular matrix" Yes No "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 39: CACO-2 - Unknown function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoli, Plasma membrane" "HPA049280: , HPA078816: " "unprognostic (1.52e-3)" "unprognostic (1.36e-1)" "unprognostic (1.18e-1)" "unprognostic (4.51e-4)" "unprognostic (2.47e-2)" "unprognostic (7.61e-3)" "unprognostic (1.22e-1)" "unprognostic (4.59e-2)" "unprognostic (2.32e-2)" "unprognostic (8.82e-2)" "unprognostic (9.20e-3)" "unprognostic (7.12e-2)" "prognostic favorable (8.17e-11)" "unprognostic (3.32e-2)" "unprognostic (5.63e-2)" "unprognostic (1.69e-2)" "unprognostic (9.90e-4)" 3.4 1.0 6.1 0.5 5.8 0.7 0.5 40.0 8.1 0.7 3.5 0.7 2.1 1.3 0.1 0.3 2.2 0.6 0.6 6.0 5.6 7.8 0.5 4.7 0.4 4.4 5.6 0.4 5.8 0.3 3.8 0.2 5.4 1.7 0.2 2.5 0.5 4.2 0.3 1.2 1.4 2.0 2.7 0.4 0.6 0.4 7.2 0.0 0.7 0.1 0.0 0.4 0.3 4.8 0.6 36.3 0.1 0.2 0.2 0.0 1.0 1.9 2.3 3.8 2.0 56.0 9.7 0.0 15.8 2.5 1.2 0.6 8.5 0.0 1.6 0.2 0.3 1.9 1.2 0.6 0.0 0.1 0.4 0.2 0.2 0.1 0.1 1.0 0.1 0.1 0.1 0.5 0.4 0.5 0.1 0.2 13.6 0.1 2.4 0.1 0.2 0.0 24.6 0.1 14.1 9.7 2.5 0.7 0.3 2.9 0.5 0.3 0.6 7.4 17.7 1.8 0.7 0.3 0.2 0.1 1.6 0.2 1.1 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 6.1 5.8 40.0 8.1 6.0 5.6 4.4 5.6 5.4 2.7 7.2 4.8 0.3 16.0 1.5 5.2 0.0 0.1 0.2 0.0 0.0 3.9 0.2 0.8 0.5 8.6 1.3 1.8 0.0 0.1 0.1 0.7 5.9 8.5 0.6 0.8 0.3 1.4 0.0 0.0 24.6 0.9 0.1 0.6 0.0 0.5 0.0 0.1 0.4 0.4 0.0 15.2 38.4 0.1 0.0 0.6 0.0 0.0 0.3 0.1 1.8 10.3 0.0 0.2 0.0 12.5 12.0 1.9 0.1 0.0 0.0 0.4 2.3 11.4 0.0 0.4 0.0 0.2 0.2 0.1 0.3 0.0 0.3 0.0 0.2 0.0 0.1 0.1 MMP25 "MMP20, MMPL1, MT6-MMP" ENSG00000008516 "Matrix metallopeptidase 25" Q9NPA2 16 3046062-3060726 "Enzymes, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 33.1;lymphoid tissue: 81.8" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 6.7;Langerhans cells: 5.8;monocytes: 15.0" "Cancer enriched" "Detected in many" 5 "testis cancer: 7.1" "Low region specificity" "Detected in single" "Group enriched" "Detected in some" 5 "basophil: 18.3;neutrophil: 20.3" "Lineage enriched" "Detected in single" 39 "granulocytes: 20.3" "Cell line enriched" "Detected in some" 15 "HMC-1: 102.2" "Not detected" "Not detected" "Low region specificity" "Detected in many" "CAB025177, HPA055640" Uncertain Supported "Plasma membrane" "Secreted to blood" NA NA 120000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 2: Immune cells - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 3: Monocytes - Immune response regulation" "Plasma membrane" "CAB025177: , HPA055640: " "unprognostic (4.51e-3)" "unprognostic (9.28e-3)" "unprognostic (7.57e-2)" "unprognostic (2.95e-3)" "unprognostic (2.26e-1)" "prognostic favorable (1.09e-5)" "unprognostic (1.36e-1)" "unprognostic (7.39e-3)" "unprognostic (7.63e-3)" "unprognostic (2.29e-2)" "unprognostic (1.51e-1)" "unprognostic (2.53e-2)" "unprognostic (2.37e-3)" "unprognostic (1.17e-2)" "unprognostic (8.30e-2)" "unprognostic (4.01e-1)" "unprognostic (2.02e-1)" 5.8 0.4 0.5 15.1 0.4 33.1 1.4 0.3 1.6 0.7 0.6 1.7 1.1 0.5 0.1 1.3 6.2 1.1 2.4 0.3 0.3 1.4 2.9 14.4 2.6 0.6 0.5 0.4 1.2 0.2 0.8 1.0 0.6 1.0 1.4 0.0 1.2 0.1 0.5 0.7 3.5 0.9 0.3 81.8 1.9 0.4 0.7 1.4 1.2 3.5 1.9 2.2 0.9 0.3 0.0 0.0 1.2 2.9 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.7 0.7 0.1 0.0 6.7 0.5 0.0 0.0 0.0 0.0 0.2 102.2 0.1 0.1 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.3 0.0 5.7 2.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.0 0.0 0.2 0.3 7.0 0.3 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.1 1.1 0.1 18.3 0.2 4.0 0.0 0.0 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 20.3 0.5 0.0 0.4 0.2 0.0 0.5 0.4 0.3 1.6 0.3 0.3 0.6 0.5 0.6 0.3 0.7 0.3 1.0 3.2 6.7 0.0 0.7 0.4 0.4 0.2 0.0 0.8 2.0 1.3 1.0 0.0 0.8 1.8 0.0 0.0 1.8 0.2 0.0 0.4 0.0 1.2 1.2 1.0 0.0 2.7 1.6 0.6 0.2 0.6 1.1 3.8 1.3 0.2 0.0 0.3 0.1 0.0 1.9 0.2 0.0 3.5 5.8 0.0 0.0 3.3 0.0 1.0 15.0 0.3 3.1 1.5 0.5 1.3 0.0 0.7 0.8 0.4 1.2 0.2 0.1 0.0 0.0 0.7 0.9 0.1 0.2 0.6 0.3 0.0 4.0 0.1 0.3 0.3 MMP26 "endometase, MGC126590, MGC126592" ENSG00000167346 "Matrix metallopeptidase 26" Q9NRE1 11 4704927-4992429 "Enzymes, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in single" 24 "endometrium 1: 13.1" "Group enriched" "Detected in some" 7 "Endometrial ciliated cells: 44.8;Glandular and luminal cells: 171.1" "Cancer enriched" "Detected in some" 4 "endometrial cancer: 8.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted to extracellular matrix" NA NA "Cluster 89: Fibroblasts - ECM organization" "Cluster 44: Endometrium - Transcription" "unprognostic (4.21e-3)" "unprognostic (2.63e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 44.8 14.6 0.3 0.0 0.0 0.0 0.0 0.0 0.4 0.0 171.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 MMP27 ENSG00000137675 "Matrix metallopeptidase 27" Q9H306 11 102691487-102705769 "Enzymes, Predicted intracellular proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "breast: 4.7;salivary gland: 1.9;skin 1: 2.4" "Cell type enhanced" "Detected in some" "Basal squamous epithelial cells: 1.2;Fibroblasts: 4.2;Langerhans cells: 1.8;Suprabasal keratinocytes: 1.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA069097 Approved "Intracellular and membrane" NA NA "Cluster 31: Skin - Epidermis development" "Cluster 50: Fibroblasts - ECM organization" "HPA069097: AB_2686085" "unprognostic (3.99e-2)" "unprognostic (2.37e-4)" "unprognostic (1.25e-3)" "unprognostic (1.63e-1)" "unprognostic (4.60e-1)" 1.2 0.0 0.0 0.0 0.0 1.3 4.7 0.0 0.0 0.2 0.0 0.4 0.1 0.3 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 1.9 0.0 0.4 2.4 0.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 1.4 0.1 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.0 1.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 4.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 1.3 0.0 0.1 0.0 0.0 0.0 MMP28 "EPILYSIN, MM28, MMP-25, MMP-28" ENSG00000271447 "Matrix metallopeptidase 28" Q9H239 17 35756249-35795707 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 47.7;Basal respiratory cells: 56.8;Distal enterocytes: 82.0;Paneth cells: 46.2;Proximal enterocytes: 47.2;Urothelial cells: 43.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "naive CD4 T-cell: 6.3;naive CD8 T-cell: 3.7" "Lineage enriched" "Detected in single" 7 "T-cells: 6.3" "Cell line enhanced" "Detected in some" "CAPAN-2: 13.8;HaCaT: 86.9;hTCEpi: 38.3;OE19: 41.7;RT4: 15.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA057288, HPA057890" Approved "Nucleoplasm,Focal adhesion sites" "Secreted to extracellular matrix" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 27: Brain & Skin - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "Focal adhesion sites" "HPA057288: , HPA057890: " "unprognostic (7.99e-3)" "unprognostic (3.27e-1)" "unprognostic (2.20e-1)" "unprognostic (1.01e-1)" "unprognostic (7.52e-2)" "unprognostic (1.63e-1)" "unprognostic (6.90e-2)" "unprognostic (1.09e-2)" "unprognostic (1.51e-1)" "unprognostic (1.99e-1)" "prognostic unfavorable (6.28e-6)" "unprognostic (9.37e-2)" "unprognostic (1.31e-1)" "unprognostic (8.87e-2)" "unprognostic (1.74e-1)" "unprognostic (1.76e-2)" "unprognostic (3.27e-3)" 14.7 2.0 18.7 0.5 18.1 0.2 8.3 12.1 18.8 4.1 11.9 17.5 1.8 5.2 2.1 13.5 6.1 1.4 3.8 16.2 15.6 1.9 0.3 14.1 0.2 15.2 17.8 1.1 0.8 0.1 1.3 2.0 12.9 5.0 10.5 3.0 2.5 3.5 1.8 23.7 10.2 4.1 14.4 1.1 8.8 22.3 19.3 0.3 5.9 2.4 3.2 16.3 7.6 13.9 0.2 0.8 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 13.8 0.1 1.5 0.0 0.1 86.9 0.0 0.2 0.0 0.0 0.7 0.0 0.2 0.0 4.3 0.0 0.0 1.2 38.3 0.0 3.1 0.7 0.3 0.3 0.0 0.2 0.0 0.3 0.1 0.3 0.0 41.7 0.1 0.8 0.0 0.0 0.0 15.7 0.2 0.7 0.8 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.6 0.0 1.1 0.6 0.2 1.0 0.0 0.4 6.3 3.7 0.0 0.9 0.2 0.9 0.0 0.4 18.7 18.1 12.1 18.8 16.2 15.6 15.2 17.8 12.9 14.4 19.3 13.9 31.5 28.9 26.5 47.7 0.4 38.5 5.3 56.8 21.1 2.7 1.0 1.5 1.3 7.2 15.2 7.3 0.0 0.0 0.2 82.0 0.0 1.2 6.7 0.1 0.0 16.8 3.6 0.4 2.8 0.4 0.0 4.4 12.2 0.1 0.0 0.0 17.9 0.0 0.1 1.7 4.8 32.9 2.0 0.0 1.8 13.4 1.2 0.5 3.6 10.3 0.4 9.4 1.0 1.0 0.6 16.7 46.2 3.0 0.1 8.6 47.2 0.8 4.5 0.5 6.6 0.7 5.5 1.1 3.7 34.9 33.1 0.0 1.0 0.1 21.5 43.9 MMP3 "STMY, STMY1" ENSG00000149968 "Matrix metallopeptidase 3" P08254 11 102835801-102843609 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 90.7;salivary gland: 286.1" "Cell type enhanced" "Detected in some" "Basal prostatic cells: 20.4;Basal respiratory cells: 25.8;Early spermatids: 24.2;Extravillous trophoblasts: 13.4;Fibroblasts: 17.9;Prostatic glandular cells: 11.9;Smooth muscle cells: 10.2" "Cancer enhanced" "Detected in many" "head and neck cancer: 59.9" "Region enriched" "Detected in some" 4 "thalamus: 7.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 18 "BJ: 1545.7;BJ hTERT+: 4229.3;fHDF/TERT166: 1846.6" "Not detected" "Not detected" "Region enhanced" "Detected in some" "hippocampal formation: 3.2" HPA007875 Uncertain Supported Vesicles "Secreted to extracellular matrix" NA NA 2540000 460000 "Cluster 24: Salivary gland - Salivary secretion" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 50: Fibroblasts - ECM organization" Vesicles "HPA007875: AB_1079396" "unprognostic (2.27e-1)" "prognostic unfavorable (9.73e-4)" "unprognostic (1.63e-3)" "unprognostic (5.11e-3)" "unprognostic (3.78e-1)" "unprognostic (5.11e-2)" "unprognostic (5.26e-6)" "unprognostic (3.46e-2)" "unprognostic (7.14e-2)" "unprognostic (2.87e-1)" "prognostic unfavorable (4.09e-4)" "unprognostic (3.26e-2)" "unprognostic (1.22e-15)" "unprognostic (3.17e-1)" "unprognostic (1.55e-1)" "unprognostic (3.43e-2)" "unprognostic (2.34e-1)" 90.7 0.1 0.3 20.1 0.4 0.0 36.6 0.2 1.6 0.3 0.1 6.1 2.4 38.1 0.2 0.8 0.2 1.9 0.2 0.4 1.6 0.4 1.6 0.3 0.0 0.4 0.4 0.1 0.3 0.1 0.9 0.4 0.3 2.2 2.3 0.0 286.1 2.2 39.6 63.7 4.5 1.6 0.3 0.0 10.5 0.1 7.3 0.1 2.6 0.4 1.3 13.9 0.5 0.3 0.0 0.0 0.0 0.1 0.4 0.0 0.0 1545.7 4229.3 27.0 8.7 0.1 0.2 0.0 0.0 1846.6 96.9 0.0 0.1 0.1 45.1 0.0 0.0 0.0 0.0 1.0 0.7 0.0 0.0 4.6 0.2 122.0 5.3 0.0 0.0 0.0 0.2 0.3 4.7 0.0 0.0 0.0 0.2 0.4 0.9 0.0 0.2 0.0 0.1 0.0 0.1 0.0 2.3 0.0 0.0 0.9 0.0 0.3 0.0 140.5 13.1 1.6 0.5 0.0 0.0 0.2 56.8 0.0 7.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.2 1.6 0.4 1.6 0.4 0.4 0.3 0.3 7.3 0.3 0.0 3.2 0.0 0.0 0.0 8.4 20.4 25.8 0.0 0.0 0.1 0.1 0.3 4.3 7.6 0.0 0.0 0.1 0.0 0.0 0.0 0.8 24.2 0.0 0.3 0.5 0.0 0.0 0.2 1.4 13.4 17.9 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 4.1 0.0 2.2 1.2 0.0 0.3 0.0 0.0 0.6 0.0 0.0 0.0 0.0 3.5 4.0 0.0 0.0 11.9 1.0 0.9 0.1 0.0 0.0 1.8 10.2 0.0 1.8 0.0 3.4 0.3 0.6 0.0 0.8 7.4 MMP7 "MPSL1, PUMP-1" ENSG00000137673 "Matrix metallopeptidase 7" P09237 11 102520508-102530750 "Cancer-related genes, Enzymes, Plasma proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 509.9;salivary gland: 267.9;urinary bladder: 211.2" "Cell type enriched" "Detected in many" 8 "Ductal cells: 8176.2" "Cancer enhanced" "Detected in all" "pancreatic cancer: 352.1" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 145.9;CAPAN-2: 815.9;EFO-21: 189.8;RPTEC TERT1: 350.1" "Not detected" "Not detected" "Not detected" "Not detected" "CAB025869, HPA051358" Supported Approved Nucleoplasm,Vesicles "Secreted to extracellular matrix" NA NA 2810000 35000 "Cluster 5: Breast - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 1: Pancreatic cells - Digestion" "Nucleoplasm, Vesicles" "CAB025869: , HPA051358: AB_2681452" "unprognostic (1.06e-3)" "unprognostic (9.51e-2)" "unprognostic (4.15e-2)" "unprognostic (1.38e-1)" "unprognostic (7.70e-3)" "unprognostic (7.28e-2)" "prognostic unfavorable (2.53e-4)" "prognostic unfavorable (3.38e-4)" "unprognostic (3.96e-2)" "unprognostic (5.63e-2)" "unprognostic (6.59e-3)" "unprognostic (1.51e-1)" "unprognostic (6.36e-3)" "unprognostic (1.42e-2)" "unprognostic (5.54e-2)" "unprognostic (1.48e-1)" "unprognostic (1.46e-1)" 3.8 0.1 0.0 2.0 0.0 0.3 168.7 0.0 0.3 13.3 0.0 1.6 0.6 97.4 27.9 21.3 91.2 509.9 0.2 0.0 0.0 140.2 3.4 31.6 1.9 0.0 0.0 0.7 85.2 0.0 0.3 0.8 0.0 54.0 1.0 0.0 267.9 34.9 0.1 32.4 0.6 4.8 0.0 0.2 7.3 0.6 0.4 3.3 0.4 0.0 29.3 211.2 1.7 0.0 0.2 145.9 0.0 0.4 0.0 0.0 0.2 0.0 2.1 0.1 0.1 1.9 815.9 0.0 189.8 0.0 0.0 1.1 0.0 0.1 0.1 0.7 0.0 0.0 0.0 0.6 1.0 0.1 0.2 0.7 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.2 0.1 0.0 0.5 11.8 0.0 0.0 0.0 0.0 350.1 1.0 0.0 0.0 0.0 0.0 0.0 3.9 0.3 0.1 0.0 0.7 3.0 0.0 1.6 0.1 0.6 0.4 1.0 5.9 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.7 86.6 43.3 0.0 1.5 1.0 382.2 135.4 1.2 0.0 124.2 93.7 0.7 100.1 401.2 1017.0 0.0 0.7 2.9 1.2 0.0 8176.2 6.1 62.1 3.3 8.8 0.0 0.0 0.0 209.4 0.3 3.4 0.0 124.6 2.5 0.0 0.0 0.0 98.0 0.0 0.0 0.0 38.7 0.6 0.3 10.3 11.8 12.6 0.0 0.0 65.2 0.0 0.0 0.0 0.0 850.9 0.0 0.0 0.1 603.3 0.0 33.9 72.6 0.0 0.0 0.0 31.4 0.1 0.2 17.0 2.4 0.8 3.6 0.0 2.3 840.8 MMP8 CLG1 ENSG00000118113 "Matrix metallopeptidase 8" P22894 11 102711796-102727050 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 36 "bone marrow: 501.1" "Group enriched" "Detected in some" 6 "Hofbauer cells: 4.0;Macrophages: 1.5" "Cancer enriched" "Detected in single" 17 "melanoma: 5.7" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "non-classical monocyte: 1.7" "Lineage enhanced" "Detected in single" "monocytes: 1.7" "Cell line enriched" "Detected in some" 8 "WM-115: 70.7" "Not detected" "Not detected" "Not detected" "Not detected" "HPA021221, HPA021763, HPA022935" Enhanced Approved Vesicles "Secreted to extracellular matrix" NA NA 360000 "Cluster 7: Monocytes - Unknown function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 17: WM-115 - Nervous system development" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Vesicles "HPA021221: AB_1854043, HPA021763: , HPA022935: AB_1854044" "unprognostic (3.03e-1)" "unprognostic (8.49e-5)" "unprognostic (1.08e-2)" "unprognostic (3.95e-3)" "unprognostic (1.80e-1)" "unprognostic (1.01e-2)" "unprognostic (7.68e-3)" "unprognostic (1.27e-1)" "unprognostic (4.92e-2)" "unprognostic (6.64e-3)" "unprognostic (2.45e-6)" "unprognostic (2.33e-4)" "unprognostic (1.33e-1)" "unprognostic (4.97e-1)" "unprognostic (2.30e-2)" 0.5 0.0 0.0 0.3 0.1 501.1 0.2 0.1 0.2 0.0 0.2 0.1 0.0 1.9 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.2 0.6 4.1 0.2 0.1 0.0 0.0 0.0 0.0 0.2 0.7 0.2 0.0 0.0 0.0 0.2 0.0 0.1 0.5 0.0 0.2 0.0 13.8 0.1 0.0 0.6 2.6 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 9.1 0.0 0.0 0.1 0.0 4.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 70.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.7 0.0 0.0 0.9 0.0 0.1 0.1 0.2 0.0 0.0 0.1 0.0 0.2 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 MMP9 CLG4B ENSG00000100985 "Matrix metallopeptidase 9" P14780 20 46008908-46016561 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 11 "bone marrow: 376.0;lymphoid tissue: 105.3" "Group enriched" "Detected in many" 5 "Hofbauer cells: 260.1;Langerhans cells: 606.0;Macrophages: 230.6" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in some" 4 "cerebral cortex: 3.1;thalamus: 4.8" "Immune cell enriched" "Detected in some" 127 "neutrophil: 272.2" "Lineage enriched" "Detected in single" 341 "granulocytes: 272.2" "Cell line enriched" "Detected in some" 13 "NB-4: 360.6" "Low region specificity" "Detected in many" "Not detected" "Not detected" "CAB000348, HPA001238, HPA063909, CAB068199, CAB068200, CAB068201" Enhanced Approved Cytosol "Secreted to blood" NA NA 43300000 61000000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 24: NB-4 - Immune response" "Cluster 4: Macrophages - Innate immune response" Cytosol "CAB000348: , CAB068199: AB_2665675, CAB068200: AB_2665676, CAB068201: AB_2665677, HPA001238: AB_1079398, HPA063909: AB_2685150" "unprognostic (4.62e-2)" "unprognostic (1.64e-1)" "unprognostic (2.85e-2)" "prognostic favorable (2.55e-4)" "unprognostic (6.65e-3)" "unprognostic (2.82e-1)" "prognostic unfavorable (7.19e-4)" "unprognostic (1.54e-1)" "unprognostic (8.57e-2)" "unprognostic (3.21e-2)" "unprognostic (4.15e-2)" "unprognostic (1.96e-1)" "prognostic unfavorable (4.05e-5)" "unprognostic (4.65e-1)" "unprognostic (9.85e-3)" "unprognostic (2.48e-2)" "unprognostic (2.17e-3)" 19.5 0.6 0.5 61.9 0.8 376.0 8.2 0.4 3.1 2.9 0.8 5.7 11.6 1.0 0.0 2.2 2.2 3.0 3.2 0.3 0.9 2.6 3.8 21.1 103.2 0.8 0.5 0.8 1.6 0.1 1.1 2.0 0.7 1.9 3.4 0.6 3.6 0.4 0.7 3.2 12.4 1.9 0.4 105.3 11.3 1.3 4.8 17.0 2.1 0.9 36.5 12.0 1.1 0.2 0.2 0.4 0.2 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 3.3 0.3 28.8 0.0 0.3 0.4 0.0 1.4 0.0 0.3 0.5 0.1 0.0 0.0 0.0 0.6 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.4 0.0 4.0 0.0 360.6 0.8 0.0 0.2 0.4 0.3 0.1 0.0 0.0 0.6 0.6 0.0 0.6 0.0 3.7 0.3 1.2 0.3 10.3 10.9 0.1 0.3 0.3 0.2 0.2 0.1 0.8 0.2 0.0 0.7 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 272.2 0.0 0.3 0.0 0.0 0.5 0.5 0.8 0.4 3.1 0.3 0.9 0.8 0.5 0.7 0.4 4.8 0.2 0.7 0.0 5.5 0.0 3.9 34.3 0.1 61.5 0.0 3.8 0.5 2.0 0.4 1.5 0.9 0.0 8.4 1.5 2.0 0.0 0.0 0.8 0.9 0.0 0.1 7.2 0.0 0.0 0.1 1.8 2.4 2.5 0.0 0.1 1.3 0.2 0.0 0.0 260.1 3.3 0.2 0.5 0.0 1.3 606.0 0.3 0.0 230.6 56.9 0.0 2.3 1.2 0.0 0.0 0.0 1.8 0.0 0.0 0.9 0.1 0.0 0.3 6.9 5.3 0.0 0.2 45.5 6.7 11.2 0.2 28.1 1.9 3.4 0.3 0.0 0.1 MPND FLJ14981 ENSG00000008382 "MPN domain containing" Q8N594 19 4343527-4360086 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 84.7;Paneth cells: 42.7;Proximal enterocytes: 50.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043274, HPA045475" Approved Approved "Nucleoplasm,Nucleoli rim" No No "Cluster 38: Basophils - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoli rim" Nucleoplasm "HPA043274: AB_2678403, HPA045475: AB_2679339" "unprognostic (3.16e-2)" "prognostic favorable (2.99e-4)" "unprognostic (4.85e-2)" "prognostic favorable (6.12e-4)" "unprognostic (8.60e-2)" "unprognostic (5.37e-3)" "unprognostic (3.16e-2)" "prognostic favorable (1.55e-4)" "unprognostic (1.23e-1)" "unprognostic (2.87e-2)" "unprognostic (3.94e-3)" "unprognostic (5.18e-2)" "prognostic favorable (7.04e-4)" "unprognostic (2.22e-3)" "unprognostic (3.22e-1)" "unprognostic (5.44e-2)" "unprognostic (9.04e-2)" 10.5 21.9 22.6 9.3 22.4 15.8 10.7 27.1 35.0 13.2 20.8 25.4 30.6 11.9 8.6 18.1 11.5 9.5 22.4 23.1 20.5 22.7 46.5 12.6 11.7 22.7 20.7 13.0 24.4 15.4 11.0 6.9 23.3 19.0 16.2 4.0 17.2 9.6 23.2 15.6 19.8 6.5 19.4 15.2 20.1 6.6 20.6 10.2 13.3 14.4 7.1 15.2 12.7 25.0 16.0 13.2 21.3 24.6 13.1 6.1 21.7 7.6 7.2 6.2 7.6 25.6 8.1 14.4 23.3 9.9 18.2 16.1 9.8 13.2 3.4 16.4 21.5 11.0 18.4 37.4 10.0 14.9 19.1 9.4 9.4 6.8 7.1 9.3 18.9 37.4 6.0 36.4 7.8 41.8 35.4 12.6 9.8 26.5 18.2 28.8 6.5 21.0 15.5 25.4 23.7 24.3 13.5 19.4 9.9 12.1 13.0 18.1 7.3 9.8 10.4 60.4 15.4 30.1 20.1 9.7 10.9 8.3 11.5 9.3 3.1 1.5 1.3 3.7 2.1 1.0 1.6 1.9 2.9 1.6 1.0 1.1 0.8 1.7 1.8 2.9 3.7 1.3 22.6 22.4 27.1 35.0 23.1 20.5 22.7 20.7 23.3 19.4 20.6 25.0 6.1 0.0 3.7 1.6 5.1 5.4 8.4 1.4 3.4 8.2 9.5 8.5 13.9 11.5 2.7 11.0 2.1 13.6 9.8 84.7 0.0 4.1 0.8 8.0 6.1 6.0 16.7 2.5 2.6 5.1 11.9 5.2 9.2 8.9 4.5 7.8 5.7 23.5 14.8 6.7 2.4 31.2 2.0 26.0 9.6 3.9 6.2 14.4 3.6 1.9 8.8 8.6 21.6 3.5 2.1 4.3 42.7 3.8 7.7 6.9 50.7 15.0 2.3 5.6 6.6 6.1 11.7 0.2 7.6 7.8 8.4 10.4 6.3 9.1 34.6 9.6 MYSM1 KIAA1915 ENSG00000162601 "Myb like, SWIRM and MPN domains 1" Q5VVJ2 1 58643440-58700077 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Immunity, Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Chromatin regulator, DNA-binding, Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 106.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA054291, HPA057306" Approved Supported Nucleoplasm,Nucleoli NA NA "Cluster 6: Non-specific - Transcription" "Cluster 50: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" Nucleoplasm Nucleoli "HPA054291: AB_2682438, HPA057306: " "unprognostic (2.95e-3)" "unprognostic (3.64e-2)" "unprognostic (3.20e-2)" "unprognostic (8.68e-2)" "unprognostic (2.08e-2)" "prognostic favorable (5.09e-5)" "unprognostic (8.12e-3)" "unprognostic (9.63e-3)" "unprognostic (5.72e-3)" "unprognostic (3.74e-1)" "unprognostic (2.25e-1)" "unprognostic (4.56e-2)" "unprognostic (2.38e-3)" "unprognostic (4.22e-2)" "unprognostic (1.83e-1)" "unprognostic (8.45e-2)" "unprognostic (1.44e-2)" 11.2 7.5 4.0 4.4 3.9 12.5 12.0 4.3 5.9 11.9 4.2 11.8 5.4 10.6 6.2 10.0 10.2 3.1 10.5 4.1 3.9 7.2 8.0 10.1 6.3 3.9 3.7 13.2 12.1 5.9 8.7 4.4 3.9 9.6 4.4 8.4 11.8 4.1 10.0 10.5 12.6 3.6 3.7 11.4 9.9 4.4 3.9 5.3 11.5 3.1 4.9 9.3 11.1 4.4 10.1 2.6 5.0 6.7 6.0 7.2 10.5 5.9 5.6 5.1 3.9 5.3 4.2 10.3 1.8 3.8 4.8 7.4 7.7 2.1 11.0 6.2 4.3 11.3 2.1 5.1 7.4 19.6 9.7 5.4 5.9 7.5 3.8 6.1 1.2 4.2 12.6 6.3 6.8 2.6 7.8 16.3 11.4 3.5 3.5 7.3 16.4 6.1 4.6 3.8 5.8 6.6 4.4 9.4 13.9 9.0 3.1 10.6 4.9 9.3 4.6 6.4 11.3 10.8 5.8 13.9 5.8 13.7 11.6 0.9 0.3 0.1 0.3 0.4 0.2 0.4 0.3 0.3 0.1 0.3 0.5 0.4 1.0 0.1 0.5 0.4 0.4 0.1 4.0 3.9 4.3 5.9 4.1 3.9 3.9 3.7 3.9 3.7 3.9 4.4 36.5 22.4 33.7 47.7 26.0 19.1 22.8 13.5 30.7 19.5 25.6 21.0 28.2 10.0 35.1 11.0 25.0 8.4 36.6 22.1 15.6 8.8 3.9 22.1 34.8 25.4 16.2 14.1 87.4 9.4 5.7 20.8 19.9 36.9 56.3 30.1 23.9 16.3 11.3 18.5 58.2 17.0 24.4 13.9 14.2 6.3 12.8 22.2 8.8 35.6 21.3 12.7 22.6 58.3 106.9 12.7 13.1 17.3 29.5 19.3 19.2 8.8 21.2 27.8 26.3 28.8 21.5 15.5 20.6 25.0 18.5 11.4 30.8 22.0 18.5 26.4 NAALAD2 "GCPIII, NAALADASE2" ENSG00000077616 "N-acetylated alpha-linked acidic dipeptidase 2" Q9Y3Q0 11 90131515-90192894 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Carboxypeptidase, Dipeptidase, Hydrolase, Metalloprotease, Multifunctional enzyme, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pituitary gland: 19.9;testis: 13.9" "Group enriched" "Detected in many" 4 "Early spermatids: 39.7;Excitatory neurons: 109.3;Horizontal cells: 70.7;Inhibitory neurons: 110.2;Oligodendrocyte precursor cells: 153.8;Oligodendrocytes: 83.7" "Cancer enhanced" "Detected in some" "testis cancer: 1.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CACO-2: 19.2;SH-SY5Y: 6.1;SuSa: 4.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA060820, HPA065419" Approved Approved Nucleoplasm NA NA "Cluster 43: Testis - Unknown function" "Cluster 39: CACO-2 - Unknown function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA060820: AB_2684373, HPA065419: AB_2685487" "unprognostic (1.68e-1)" "unprognostic (2.66e-3)" "unprognostic (1.49e-1)" "unprognostic (4.52e-3)" "unprognostic (4.73e-3)" "unprognostic (2.97e-1)" "unprognostic (3.82e-3)" "unprognostic (1.77e-2)" "unprognostic (2.44e-1)" "unprognostic (2.30e-1)" "unprognostic (3.30e-2)" "unprognostic (8.00e-2)" "unprognostic (9.97e-4)" "unprognostic (1.52e-2)" "unprognostic (2.54e-1)" "unprognostic (1.63e-2)" "unprognostic (2.93e-1)" 3.8 10.0 2.3 0.4 3.3 0.1 3.3 1.5 5.3 10.3 0.0 1.9 0.2 4.1 1.9 0.8 3.4 1.2 2.1 2.4 2.8 1.5 0.9 2.1 0.4 3.6 3.5 7.4 0.7 0.1 19.9 3.5 3.4 3.2 0.6 3.5 1.1 1.2 1.1 0.7 1.3 1.1 2.0 2.6 1.2 13.9 3.0 0.1 1.4 0.7 0.1 2.2 4.0 4.2 0.1 0.2 1.8 0.1 0.5 0.1 2.2 0.1 0.1 0.1 0.0 19.2 0.7 0.3 0.2 0.0 0.3 0.3 1.3 0.0 0.0 0.0 0.3 1.9 0.4 1.7 0.2 0.1 0.1 1.9 0.0 0.0 0.0 0.5 0.4 0.2 0.1 0.0 0.0 0.0 0.3 0.3 1.8 0.5 0.2 0.3 0.0 0.2 0.0 0.0 0.2 6.1 0.0 0.2 0.0 4.3 0.2 0.4 2.4 0.1 1.4 0.3 0.3 1.0 0.3 0.3 0.6 0.3 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 2.3 3.3 1.5 5.3 2.4 2.8 3.6 3.5 3.4 2.0 3.0 4.2 2.6 0.0 0.0 3.3 0.1 0.3 0.1 0.0 0.0 17.3 0.0 0.0 2.4 1.5 0.6 0.0 0.0 1.2 0.1 0.0 0.0 0.1 39.7 0.8 13.7 1.2 0.0 0.0 109.3 0.0 0.6 7.5 1.1 0.6 0.0 1.7 0.7 0.2 0.3 70.7 110.2 0.0 0.0 7.2 0.4 17.7 11.1 0.5 0.0 12.2 0.0 8.4 0.0 153.8 83.7 0.0 0.0 14.7 0.4 0.4 0.0 0.1 0.0 2.4 0.0 6.4 4.6 0.6 11.3 0.4 0.0 0.8 0.2 19.4 0.2 0.1 NAALADL1 ENSG00000168060 "N-acetylated alpha-linked acidic dipeptidase like 1" Q9UQQ1 11 65044818-65058553 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 4 "intestine: 99.3" "Cell type enriched" "Detected in many" 11 "Proximal enterocytes: 588.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 182.0" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "ASC TERT1: 5.8;fHDF/TERT166: 7.8;HHSteC: 20.2;HSkMC: 13.5;SCLC-21H: 10.5" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA047123 Enhanced Uncertain Cytosol NA NA "Cluster 46: Basophils - DNA binding" "Cluster 9: Intestine - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 45: Enterocytes - Digestion" Cytosol "HPA047123: AB_2679942" "unprognostic (2.98e-2)" "unprognostic (2.06e-1)" "unprognostic (1.58e-1)" "unprognostic (8.76e-2)" "unprognostic (1.70e-1)" "unprognostic (1.28e-3)" "unprognostic (1.36e-1)" "unprognostic (1.40e-1)" "unprognostic (1.89e-2)" "unprognostic (1.38e-1)" "unprognostic (3.03e-1)" "unprognostic (2.18e-1)" "unprognostic (1.75e-4)" "unprognostic (2.10e-3)" "unprognostic (3.22e-2)" "unprognostic (1.45e-1)" "unprognostic (4.80e-2)" 13.9 3.2 4.4 6.6 4.1 21.1 12.1 4.7 6.0 23.5 7.0 18.4 19.8 18.8 4.6 7.3 15.2 9.4 10.5 3.9 4.1 7.4 2.6 10.9 10.9 4.7 4.3 16.6 2.3 2.0 6.0 2.3 4.6 13.8 7.1 1.9 4.9 11.5 2.7 5.4 99.3 10.5 4.6 15.3 8.2 8.7 4.4 3.4 5.7 4.1 6.9 12.7 14.5 4.0 0.0 0.0 0.1 0.2 0.5 5.8 1.0 2.3 0.0 2.8 1.3 0.0 0.0 0.1 0.0 7.8 0.0 0.0 0.0 0.2 0.1 0.9 0.4 0.0 0.2 3.5 20.2 0.0 0.0 13.5 0.0 2.7 0.0 0.1 3.6 0.1 0.0 0.3 0.0 0.2 0.2 0.7 0.0 0.1 0.1 0.1 0.0 1.0 0.2 0.0 10.5 0.4 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.2 0.8 0.0 0.1 0.1 182.0 21.2 35.9 29.6 14.6 15.8 25.7 23.8 14.8 16.3 29.8 27.0 15.0 3.7 80.2 8.8 0.7 45.2 24.6 4.4 4.1 4.7 6.0 3.9 4.1 4.7 4.3 4.6 4.6 4.4 4.0 19.1 0.0 0.0 0.0 8.0 3.6 3.4 5.6 6.2 2.0 0.8 9.1 1.8 1.5 0.4 0.0 0.0 0.2 9.8 31.3 3.9 0.1 0.8 0.4 5.8 11.1 1.2 2.5 0.3 0.8 0.3 11.4 1.1 0.2 19.7 4.3 16.8 0.4 2.8 10.1 0.4 21.0 2.0 5.6 5.7 2.6 11.8 5.2 16.0 1.0 17.3 12.2 41.2 1.0 0.1 0.2 50.0 18.0 1.1 0.5 588.6 0.5 0.5 0.9 0.0 8.3 11.1 1.6 3.5 1.3 3.3 0.4 11.1 3.9 11.8 0.4 NAALADL2 ENSG00000177694 "N-acetylated alpha-linked acidic dipeptidase like 2" Q58DX5 3 174438573-175810548 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 311.5;Inhibitory neurons: 135.1;Microglial cells: 155.5;Oligodendrocyte precursor cells: 468.0;Oligodendrocytes: 532.9" "Cancer enhanced" "Detected in many" "prostate cancer: 5.2" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC TERT1: 14.5;BJ hTERT+: 5.4;fHDF/TERT166: 6.4;WM-115: 5.9" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "HPA012413, HPA017425, CAB025586" Approved Enhanced Nucleoplasm NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 89: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 68: Oligodendrocytes - Mixed function" Nucleoplasm "CAB025586: , HPA012413: AB_1854274, HPA017425: AB_1854275" "unprognostic (7.28e-3)" "unprognostic (1.10e-1)" "unprognostic (6.28e-2)" "unprognostic (1.60e-1)" "unprognostic (2.56e-1)" "unprognostic (2.56e-1)" "unprognostic (2.29e-4)" "unprognostic (3.44e-3)" "unprognostic (5.70e-2)" "unprognostic (7.42e-2)" "unprognostic (7.85e-3)" "unprognostic (9.49e-2)" "unprognostic (3.66e-6)" "unprognostic (7.11e-2)" "unprognostic (1.48e-1)" "unprognostic (9.05e-2)" "unprognostic (2.22e-2)" 2.4 1.1 1.1 1.0 2.3 0.2 5.8 1.2 1.4 6.3 1.1 3.0 1.7 3.7 5.5 1.5 3.8 4.2 2.6 1.4 0.6 3.3 2.9 2.0 0.5 2.2 1.3 3.9 2.2 10.2 0.5 1.2 1.8 4.9 2.4 1.6 5.8 3.7 1.0 0.8 1.6 3.5 1.4 1.9 2.7 0.9 1.5 1.2 2.3 1.7 0.5 3.8 1.2 3.3 0.0 0.0 0.3 0.0 4.4 14.5 0.1 3.1 5.4 0.7 0.9 0.2 1.7 0.0 0.6 6.4 0.2 0.1 0.0 0.0 2.3 0.0 0.0 0.2 0.0 0.0 0.7 0.0 0.0 4.1 0.8 0.1 0.0 3.8 0.5 0.0 0.0 0.1 3.1 0.6 0.2 0.0 0.0 2.2 0.0 0.0 0.2 0.1 2.2 0.3 0.1 0.1 0.3 0.3 1.2 0.3 4.0 0.2 0.7 2.9 0.1 0.1 0.6 0.0 0.0 0.0 1.9 0.1 5.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4 0.0 0.0 1.1 2.3 1.2 1.4 1.4 0.6 2.2 1.3 1.8 1.4 1.5 3.3 5.1 0.0 11.5 311.5 0.1 2.3 8.9 2.7 1.2 7.7 35.1 13.7 3.0 12.8 9.1 12.9 12.5 19.6 0.3 11.1 7.9 10.1 74.9 23.7 8.7 2.8 9.0 2.7 113.4 2.5 1.4 15.0 23.9 30.2 4.5 3.4 2.9 4.5 1.8 0.0 135.1 2.6 10.2 0.3 3.0 39.6 15.2 1.1 3.6 155.5 0.0 6.7 0.0 468.0 532.9 3.6 4.4 12.0 0.0 13.6 13.2 2.4 21.9 6.2 0.0 23.4 4.9 3.2 2.8 5.3 1.8 12.3 0.8 5.7 16.4 16.0 NAPSA "KAP, Kdap, NAP1, NAPA" ENSG00000131400 "Napsin A aspartic peptidase" O96009 19 50358477-50365830 "Enzymes, Metabolic proteins, Plasma proteins, Predicted secreted proteins" "Aspartyl protease, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 10 "lung: 1075.5" "Cell type enriched" "Detected in many" 5 "Alveolar cells type 2: 3072.3" "Cancer enriched" "Detected in many" 18 "lung cancer: 249.9" "Low region specificity" "Detected in some" "Immune cell enhanced" "Detected in some" "plasmacytoid DC: 8.7" "Group enriched" "Detected in many" 7 "B-cells: 4.3;dendritic cells: 8.7" "Cell line enriched" "Detected in some" 31 "U-698: 42.1" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB009591, HPA045280, HPA047236, HPA047744" Enhanced "Secreted in other tissues" NA NA 1500000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 19: Lung - Lung function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 11: Alveolar cells - Smell perception" "CAB009591: , HPA045280: AB_2679283, HPA047236: AB_2679993, HPA047744: AB_2680143" "unprognostic (5.36e-2)" "unprognostic (4.77e-2)" "unprognostic (1.64e-3)" "unprognostic (1.78e-1)" "unprognostic (1.93e-1)" "unprognostic (4.65e-2)" "unprognostic (1.02e-1)" "unprognostic (8.30e-3)" "unprognostic (2.29e-1)" "unprognostic (2.23e-2)" "unprognostic (1.76e-3)" "unprognostic (7.67e-3)" "prognostic favorable (1.21e-4)" "unprognostic (4.08e-4)" "unprognostic (3.29e-1)" "unprognostic (9.83e-3)" "unprognostic (7.26e-5)" 0.4 0.9 0.8 1.6 0.9 0.1 0.5 0.9 0.9 0.7 0.7 0.6 0.4 0.5 2.0 0.4 1.0 0.1 0.4 0.8 0.9 106.3 1.2 1075.5 1.2 0.9 0.8 2.1 1.0 0.2 0.6 0.4 0.9 1.0 0.4 0.4 0.6 1.0 0.2 1.1 1.5 0.1 0.8 1.1 0.9 1.8 1.0 0.4 1.7 0.0 0.5 0.4 0.7 1.1 0.2 0.4 0.0 0.2 0.2 0.2 0.2 0.1 0.0 0.0 0.1 0.1 0.3 0.2 0.3 0.2 0.0 0.5 0.1 0.0 0.0 0.1 0.4 0.0 0.0 0.0 0.2 0.0 0.2 0.4 1.3 0.1 0.0 0.1 0.0 0.0 0.3 0.1 0.0 0.7 0.2 0.5 0.2 0.3 0.4 0.6 0.0 0.2 1.1 0.0 0.0 0.1 0.2 0.0 0.1 0.1 0.1 0.4 0.2 0.0 0.1 1.0 0.0 0.2 0.4 42.1 0.0 0.1 0.0 0.0 0.4 0.0 0.1 0.9 0.0 4.3 0.2 0.3 2.6 1.7 0.4 0.4 0.5 0.4 0.7 8.7 0.0 1.1 0.8 0.9 0.9 0.9 0.8 0.9 0.9 0.8 0.9 0.8 1.0 1.1 0.3 522.4 3072.3 0.3 3.8 0.1 0.5 0.2 0.0 1.3 0.8 0.9 0.4 1.5 45.9 46.0 4.2 0.5 0.4 0.8 9.8 0.6 47.2 12.6 0.4 6.2 0.0 0.4 0.5 0.8 0.3 5.8 0.5 1.5 69.4 1.0 0.4 0.4 0.3 0.0 0.5 1.0 0.0 1.6 5.3 9.1 0.9 7.9 0.0 1.9 0.2 1.5 1.0 0.0 1.4 0.1 2.3 0.4 0.6 0.4 2.0 276.1 16.4 0.9 0.0 0.3 0.3 1.4 1.4 0.0 0.6 0.1 12.9 0.4 0.9 0.1 NLN "AGTBP, KIAA1226" ENSG00000123213 Neurolysin Q9BYT8 5 65722205-65871725 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 52.8;Excitatory neurons: 58.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 5 "classical monocyte: 2.6;intermediate monocyte: 3.4;myeloid DC: 2.2;non-classical monocyte: 2.3" "Group enriched" "Detected in many" 5 "dendritic cells: 2.2;monocytes: 3.4" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031862 Approved Approved Mitochondria Yes No 64000 "Cluster 7: Monocytes - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 25: RPMI-8226 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Mitochondria "HPA031862: AB_10600827" "unprognostic (5.91e-3)" "unprognostic (4.52e-2)" "unprognostic (1.34e-3)" "unprognostic (4.37e-2)" "unprognostic (3.85e-1)" "unprognostic (1.45e-2)" "unprognostic (7.29e-3)" "unprognostic (3.24e-2)" "unprognostic (3.19e-1)" "unprognostic (3.58e-1)" "prognostic unfavorable (7.51e-4)" "unprognostic (1.27e-1)" "prognostic favorable (5.58e-7)" "unprognostic (1.52e-2)" "unprognostic (1.98e-1)" "unprognostic (1.29e-1)" "unprognostic (6.18e-3)" 2.2 1.0 3.8 2.4 3.9 1.5 3.7 2.9 5.3 1.8 1.6 3.6 1.1 2.7 2.4 2.5 1.5 1.2 2.6 3.8 3.6 3.9 9.9 1.7 1.7 3.9 3.4 1.8 2.5 1.5 0.9 2.4 4.0 2.6 3.2 2.5 1.9 1.1 8.9 2.8 2.7 2.7 3.3 1.3 4.0 1.1 3.9 0.9 2.7 6.5 2.0 2.7 1.5 4.8 13.3 12.5 7.2 12.0 9.0 15.3 14.5 13.1 5.5 7.6 8.2 7.2 7.7 18.8 16.1 15.8 15.1 10.3 9.5 20.2 13.1 5.6 6.4 5.2 8.7 18.5 7.7 12.0 3.0 11.7 10.8 10.5 12.4 6.3 21.7 8.3 11.4 3.9 16.5 10.2 8.3 10.8 22.2 6.7 3.6 9.6 15.3 29.9 12.6 5.9 22.3 11.5 10.6 10.7 11.0 19.4 12.9 14.1 12.5 5.0 5.9 7.4 10.0 3.3 7.1 8.2 7.7 23.2 7.7 0.1 2.6 0.1 0.1 3.4 0.1 0.4 0.2 0.1 2.2 0.4 0.3 0.2 0.3 0.5 2.3 0.1 0.0 1.0 3.8 3.9 2.9 5.3 3.8 3.6 3.9 3.4 4.0 3.3 3.9 4.8 5.9 6.4 2.8 19.6 4.0 5.7 9.0 6.2 8.6 2.4 10.1 8.9 14.5 7.2 8.5 12.9 4.2 5.3 0.6 52.8 5.9 17.8 0.3 7.4 12.9 8.3 1.8 9.0 58.9 14.5 14.0 7.1 20.4 20.9 15.2 16.2 4.6 32.4 28.8 5.0 32.2 5.8 6.1 22.9 8.9 0.4 4.4 13.5 1.8 5.6 17.9 13.1 2.1 22.6 44.5 30.2 35.9 2.2 4.9 16.5 32.3 22.4 3.1 4.7 0.0 19.7 8.1 2.1 5.2 15.3 5.3 2.9 2.3 15.8 8.2 6.1 NPEPL1 "bA261P9.2, FLJ11583" ENSG00000215440 "Aminopeptidase like 1" Q8NDH3 20 58689131-58719238 "Enzymes, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "basophil: 23.9;classical monocyte: 18.5;eosinophil: 7.2;intermediate monocyte: 13.0;myeloid DC: 11.4;neutrophil: 13.7;non-classical monocyte: 18.8" "Group enriched" "Detected in all" 5 "dendritic cells: 11.4;granulocytes: 23.9;monocytes: 18.8" "Cell line enhanced" "Detected in many" "MCF7: 106.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004986, CAB017025, HPA036356" Approved Approved Nucleoplasm,Cytosol NA NA 14000 "Cluster 14: Monocytes - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 52: Non-specific - Transcription" Nucleoplasm Cytosol "CAB004986: AB_426073, CAB017025: , HPA036356: AB_2675082" "unprognostic (1.68e-1)" "unprognostic (5.87e-3)" "unprognostic (8.28e-2)" "unprognostic (2.78e-1)" "unprognostic (5.42e-2)" "unprognostic (1.47e-3)" "unprognostic (2.86e-3)" "unprognostic (3.11e-2)" "unprognostic (4.14e-1)" "unprognostic (1.08e-2)" "unprognostic (1.62e-3)" "unprognostic (3.78e-2)" "prognostic unfavorable (1.87e-9)" "unprognostic (7.97e-2)" "unprognostic (1.64e-1)" "unprognostic (2.21e-1)" "prognostic favorable (5.73e-4)" 31.9 24.8 20.6 9.4 21.5 19.9 28.1 20.2 28.9 20.4 22.5 40.8 15.9 24.8 3.9 26.9 23.2 15.8 30.7 20.7 19.0 40.6 20.6 26.6 13.6 22.6 20.3 23.6 24.1 16.7 27.0 10.0 20.9 29.3 4.4 2.5 29.7 15.2 66.3 23.7 25.4 8.6 19.7 40.1 27.1 23.1 22.1 7.7 39.2 28.8 6.1 39.2 22.1 21.0 22.5 31.2 5.5 4.5 11.8 21.7 1.7 8.5 0.7 26.6 14.9 18.0 16.6 1.0 44.6 15.7 0.3 24.0 7.5 10.4 2.6 20.0 7.5 8.0 26.0 8.3 29.6 8.1 13.0 21.3 31.7 9.3 0.0 9.8 22.6 6.1 1.1 3.5 10.6 106.6 3.3 21.2 8.3 13.1 33.8 6.6 2.6 12.6 11.1 14.8 10.1 3.2 22.4 6.1 41.8 3.0 23.4 15.3 25.3 6.7 5.4 14.0 4.4 11.7 4.3 0.7 9.8 15.2 2.7 23.9 18.5 7.2 2.5 13.0 3.1 1.4 1.5 1.7 11.4 0.9 0.9 1.8 13.7 3.2 18.8 0.5 3.7 6.3 20.6 21.5 20.2 28.9 20.7 19.0 22.6 20.3 20.9 19.7 22.1 21.0 23.6 9.6 15.6 0.0 3.5 9.2 8.2 17.1 10.8 19.0 17.2 16.0 16.7 10.0 16.4 27.6 25.0 15.0 11.8 7.6 13.7 14.8 2.3 11.9 8.1 13.6 12.0 3.0 0.0 9.2 7.8 16.1 18.8 6.4 2.5 32.3 15.0 9.1 11.2 8.4 0.0 10.2 20.3 16.7 12.0 8.5 22.1 15.1 7.2 0.0 16.3 20.1 6.2 0.0 0.0 10.8 14.3 14.7 8.4 4.4 17.6 19.9 19.0 8.5 19.7 14.9 15.2 6.7 3.0 16.9 11.2 8.9 9.0 9.7 13.1 7.7 NPEPPS "MP100, PSA" ENSG00000141279 "Aminopeptidase puromycin sensitive" P55786 17 47522942-47624665 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021453, HPA045649" Uncertain Supported Cytosol No No 3000000 "Cluster 50: Neutrophils - Cellular senescence" "Cluster 59: Non-specific - Translation" "Cluster 6: T47d - Mammary gland" "Cluster 44: Endometrium - Transcription" Cytosol "HPA021453: AB_2670709, HPA045649: AB_2679406" "unprognostic (1.63e-1)" "unprognostic (3.15e-2)" "prognostic favorable (3.39e-5)" "unprognostic (2.66e-2)" "unprognostic (1.53e-1)" "unprognostic (5.92e-2)" "prognostic unfavorable (3.67e-5)" "unprognostic (3.84e-2)" "unprognostic (1.22e-1)" "unprognostic (1.77e-1)" "unprognostic (3.85e-2)" "unprognostic (3.63e-2)" "unprognostic (1.93e-1)" "unprognostic (8.55e-2)" "unprognostic (1.52e-1)" "unprognostic (1.23e-2)" "unprognostic (1.07e-1)" 32.2 50.0 30.6 19.4 34.8 7.3 30.1 30.7 41.1 41.5 26.1 38.6 20.3 32.0 11.1 92.2 32.6 22.2 30.6 32.9 30.3 30.9 23.8 30.5 18.4 35.7 34.2 39.9 34.2 30.1 26.7 27.3 35.7 27.9 27.4 21.0 44.4 20.6 114.5 47.3 37.1 33.7 26.1 31.9 33.4 19.2 34.2 26.4 26.8 86.6 27.5 34.8 58.2 30.5 105.7 81.7 67.3 49.4 92.1 81.9 147.5 47.5 63.9 70.4 66.5 55.7 100.6 68.4 76.1 69.2 70.1 62.0 83.7 44.8 108.7 31.5 73.2 76.5 62.3 59.2 48.3 48.8 46.6 61.5 41.1 52.7 26.8 99.2 77.5 20.1 72.5 30.7 109.9 37.2 66.0 34.7 47.8 74.4 68.0 50.5 107.2 60.1 82.6 81.0 59.7 46.0 59.1 34.9 44.7 122.0 256.3 35.5 88.6 44.1 35.2 72.5 34.9 63.7 81.1 39.9 64.8 25.3 33.5 14.2 9.9 12.4 8.8 7.9 9.6 7.7 7.2 9.2 9.7 6.9 6.3 7.8 28.4 8.8 9.1 10.1 8.8 6.3 30.6 34.8 30.7 41.1 32.9 30.3 35.7 34.2 35.7 26.1 34.2 30.5 32.0 83.3 59.1 68.6 44.7 77.9 68.9 40.2 109.8 144.6 76.6 33.8 60.3 55.8 53.6 42.3 268.9 81.2 35.6 87.0 27.4 69.3 34.2 95.2 80.9 45.4 44.3 44.6 98.0 54.4 74.4 66.0 58.1 158.1 41.7 62.7 45.7 32.5 40.5 112.7 95.3 44.1 38.7 51.0 62.1 50.8 52.8 45.4 58.7 37.5 51.5 38.7 38.1 69.4 74.9 103.4 61.6 50.0 52.5 106.2 58.7 46.5 63.8 153.3 78.9 53.8 53.5 52.0 28.6 101.6 102.6 104.7 40.4 45.9 51.5 195.2 NRDC "hNRD1, hNRD2, NRD1" ENSG00000078618 "Nardilysin convertase" O43847 1 51789191-51878937 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 267.3" "Group enriched" "Detected in many" 9 "Early spermatids: 597.7;Late spermatids: 1672.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA053661 Approved Nucleoplasm NA NA 58000 "Cluster 5: Granulocytes - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 31: Spermatids - Spermatogenesis" Nucleoplasm "HPA053661: AB_2682221" "unprognostic (1.22e-1)" "unprognostic (6.52e-2)" "unprognostic (2.14e-2)" "unprognostic (5.62e-2)" "unprognostic (2.61e-1)" "unprognostic (3.25e-2)" "prognostic unfavorable (5.49e-6)" "unprognostic (1.42e-1)" "unprognostic (4.17e-2)" "unprognostic (1.67e-1)" "unprognostic (5.86e-2)" "unprognostic (1.00e-1)" "prognostic unfavorable (2.12e-9)" "unprognostic (2.75e-1)" "unprognostic (2.35e-2)" "unprognostic (9.54e-2)" "unprognostic (5.53e-3)" 48.2 36.8 33.3 48.2 33.9 48.5 34.2 33.6 42.3 31.1 37.2 32.5 32.3 31.1 20.2 40.4 29.7 31.0 58.5 34.4 35.5 26.5 55.7 34.3 43.8 35.2 34.6 32.6 40.1 60.9 32.8 40.2 37.8 38.6 35.3 48.1 28.7 30.5 267.3 51.4 31.4 38.4 33.6 40.9 35.2 95.6 36.5 54.9 33.1 182.0 46.7 36.5 28.4 38.1 166.8 91.0 94.2 133.4 98.9 145.5 106.8 165.6 143.9 116.6 123.5 65.6 65.3 108.3 84.7 128.4 157.6 95.1 136.5 127.9 156.2 127.7 66.1 129.5 125.4 62.9 97.9 114.4 95.4 117.2 102.1 169.7 160.0 105.0 125.7 113.1 174.7 71.7 153.4 62.9 105.0 45.2 161.5 71.8 97.4 101.6 106.4 122.6 92.8 94.7 86.5 65.2 148.0 124.8 94.5 185.7 79.3 152.5 102.4 103.8 94.2 114.2 146.0 103.9 168.4 100.1 120.8 146.6 120.1 44.5 33.8 50.0 23.2 35.1 23.3 23.2 21.5 26.0 33.7 15.6 20.9 22.7 67.8 29.8 28.3 27.5 26.9 33.1 33.3 33.9 33.6 42.3 34.4 35.5 35.2 34.6 37.8 33.6 36.5 38.1 43.5 35.3 69.0 0.0 58.9 0.0 46.3 0.0 38.7 73.3 38.2 31.0 0.0 28.6 34.7 27.6 81.3 56.8 94.3 11.1 31.3 48.1 597.7 63.1 78.8 39.4 18.2 85.8 0.0 64.0 45.5 40.1 56.6 55.4 35.3 74.6 30.4 59.9 44.3 62.2 0.0 19.5 0.0 44.6 0.0 1672.1 66.2 72.5 0.0 0.0 70.3 45.9 55.6 0.0 0.0 57.6 13.7 59.0 126.1 41.9 30.1 19.6 59.0 71.8 59.2 64.5 38.2 39.0 28.1 57.7 0.0 82.5 52.8 65.9 21.6 42.3 OMA1 "FLJ33782, MPRP-1, YKR087C, ZMPOMA1" ENSG00000162600 "OMA1 zinc metallopeptidase" Q96E52 1 58415384-58546802 "Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 106.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA055120 Approved Approved Nucleoplasm,Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Nucleoplasm, Mitochondria" "HPA055120: AB_2682702" "prognostic favorable (1.63e-4)" "unprognostic (2.67e-2)" "prognostic favorable (7.70e-4)" "unprognostic (1.60e-3)" "unprognostic (1.61e-1)" "unprognostic (9.57e-2)" "unprognostic (3.94e-3)" "prognostic favorable (8.52e-4)" "unprognostic (8.22e-3)" "unprognostic (6.91e-2)" "unprognostic (4.10e-2)" "unprognostic (1.40e-1)" "unprognostic (9.54e-3)" "unprognostic (2.52e-2)" "unprognostic (3.93e-2)" "unprognostic (1.74e-2)" "unprognostic (5.24e-3)" 11.4 18.7 15.1 14.0 22.8 12.8 19.7 23.1 14.9 16.7 14.9 20.8 14.9 13.5 17.8 13.3 19.4 15.1 19.8 13.0 19.5 28.4 31.1 11.9 23.4 18.8 17.9 13.5 17.9 18.1 10.4 11.5 21.1 20.8 20.0 20.5 19.5 16.7 28.2 12.8 14.2 12.4 15.6 20.2 17.3 8.2 18.3 20.2 20.1 29.9 21.5 14.8 10.5 27.3 31.2 13.0 8.3 7.9 41.7 39.0 24.6 12.7 13.9 10.9 13.7 4.0 18.7 69.8 26.3 13.1 37.8 31.2 31.1 31.3 13.3 55.1 17.9 22.0 10.4 16.1 20.3 54.3 14.7 37.3 33.6 10.4 22.4 24.1 9.3 34.3 42.7 20.1 29.2 19.5 18.0 19.4 12.4 47.4 28.5 22.1 27.7 29.1 23.6 20.5 8.7 4.3 26.0 41.9 37.6 38.4 19.5 20.1 5.4 5.6 10.8 27.8 13.5 16.3 23.4 46.2 16.8 42.2 14.1 20.1 14.4 32.1 19.4 24.1 25.6 35.6 23.7 23.1 15.4 35.0 33.9 31.5 17.2 30.9 35.1 8.2 23.6 15.9 15.1 22.8 23.1 14.9 13.0 19.5 18.8 17.9 21.1 15.6 18.3 27.3 8.4 19.2 11.5 37.9 25.7 6.0 18.2 35.6 13.6 7.8 15.0 12.3 27.2 8.6 33.0 25.8 12.5 22.9 14.4 8.4 25.4 11.2 5.8 31.6 10.8 6.3 6.0 15.6 18.3 5.5 10.0 12.0 5.6 18.4 6.3 10.9 6.4 18.7 15.8 1.7 31.7 17.7 36.7 10.1 9.7 12.7 9.9 12.9 7.2 29.0 11.3 10.9 15.5 52.8 106.5 3.8 10.9 8.6 16.8 12.3 8.5 32.4 63.1 20.5 6.6 12.0 8.6 14.3 13.6 17.3 6.8 18.3 20.7 17.1 14.6 17.1 OTUB1 "FLJ20113, FLJ40710" ENSG00000167770 "OTU deubiquitinase, ubiquitin aldehyde binding 1" Q96FW1 11 63985853-64001811 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Adaptive immunity, DNA damage, DNA repair, Immunity, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039176, CAB072836" Approved Supported Approved Nucleoplasm,Cytosol NA NA 500000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 27: Brain & Skin - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Cytosol" "CAB072836: , HPA039176: AB_10674980" "unprognostic (2.50e-1)" "unprognostic (5.70e-3)" "unprognostic (3.93e-2)" "unprognostic (1.63e-1)" "unprognostic (2.78e-1)" "prognostic unfavorable (3.05e-4)" "unprognostic (1.85e-3)" "unprognostic (1.34e-2)" "unprognostic (2.45e-1)" "unprognostic (1.27e-2)" "unprognostic (3.04e-1)" "unprognostic (1.34e-1)" "unprognostic (1.33e-3)" "unprognostic (6.76e-2)" "unprognostic (1.42e-1)" "unprognostic (4.84e-2)" "unprognostic (1.82e-1)" 44.8 57.0 69.9 43.0 78.0 63.5 47.3 53.0 93.4 54.1 39.7 51.9 42.0 49.0 37.4 85.4 55.8 35.9 62.4 79.3 62.5 61.3 47.0 47.1 59.8 65.0 58.0 44.5 43.9 47.1 48.6 49.3 66.1 53.5 39.3 25.6 54.3 42.6 70.2 78.1 51.9 38.0 51.2 58.6 54.0 57.1 65.0 56.0 51.9 48.4 57.1 52.5 56.7 67.7 113.4 198.9 107.2 95.7 70.7 77.8 83.0 66.0 97.1 143.6 105.1 138.1 104.5 59.3 122.0 106.6 124.4 138.1 140.4 165.4 88.1 69.9 111.7 99.3 114.1 172.9 98.8 99.2 104.3 83.4 106.4 110.2 69.8 74.4 137.2 54.6 71.2 65.3 97.9 237.2 109.2 133.0 126.5 95.4 94.1 88.3 41.8 102.5 151.1 162.1 81.5 117.5 74.6 114.1 123.3 72.9 178.2 86.3 100.1 75.8 74.2 103.3 88.4 76.2 51.7 86.4 98.4 64.0 74.5 228.8 186.8 189.9 165.5 244.2 131.2 149.6 152.1 153.6 203.1 139.3 117.1 130.4 184.6 161.8 218.9 140.7 224.7 313.4 69.9 78.0 53.0 93.4 79.3 62.5 65.0 58.0 66.1 51.2 65.0 67.7 37.0 19.2 56.5 15.0 67.2 48.3 70.9 137.8 83.6 44.4 42.5 48.8 31.9 37.1 82.5 46.0 39.6 146.2 56.5 104.7 74.3 80.7 72.6 55.4 36.2 43.4 87.8 35.5 17.8 85.5 109.2 50.0 71.9 44.3 48.7 54.6 35.7 33.2 90.4 30.3 16.9 70.8 101.7 57.4 65.9 87.1 34.2 61.0 51.6 8.4 98.0 43.2 78.2 12.5 18.8 90.1 92.0 25.6 80.8 51.8 90.8 85.2 89.2 55.7 26.3 28.1 62.0 48.0 71.4 77.7 52.6 194.8 73.7 51.7 62.7 71.6 OTUB2 "C14orf137, FLJ21916, MGC3102" ENSG00000089723 "OTU deubiquitinase, ubiquitin aldehyde binding 2" Q96DC9 14 94026340-94048930 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "skin 1: 7.3;testis: 14.4" "Group enriched" "Detected in many" 8 "Early spermatids: 641.1;Late spermatids: 1415.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "GAMG: 16.5;Karpas-707: 18.0;OE19: 18.1;RPTEC TERT1: 11.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA002329, HPA075090" Enhanced NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 27: Brain & Skin - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 34: Spermatids - Unknown function" "HPA002329: AB_1079537, HPA075090: AB_2686734" "unprognostic (6.80e-3)" "unprognostic (1.39e-3)" "unprognostic (3.68e-3)" "unprognostic (4.82e-3)" "unprognostic (1.66e-1)" "unprognostic (2.20e-1)" "unprognostic (2.30e-3)" "unprognostic (1.18e-2)" "unprognostic (2.55e-1)" "unprognostic (3.09e-3)" "unprognostic (2.80e-2)" "unprognostic (1.16e-2)" "unprognostic (6.25e-3)" "unprognostic (1.15e-1)" "unprognostic (2.06e-2)" "unprognostic (1.02e-4)" "unprognostic (3.16e-1)" 0.3 0.6 1.2 0.2 1.1 0.2 0.8 1.3 1.3 1.3 0.1 0.5 0.3 0.8 0.3 3.8 0.6 0.4 0.1 1.0 0.8 0.6 0.8 0.4 0.3 0.1 1.3 0.7 0.7 1.9 0.2 1.8 0.1 0.6 0.8 0.6 0.7 0.2 0.1 7.3 0.3 0.3 0.1 0.2 0.5 14.4 2.5 0.1 0.2 0.0 0.8 0.9 1.5 0.5 1.3 3.7 2.4 2.3 0.9 0.7 2.6 0.5 0.3 1.4 2.1 0.8 5.9 0.3 2.2 0.6 16.5 0.3 3.2 1.7 1.1 0.9 1.5 0.1 0.4 3.9 1.3 0.0 0.6 0.6 2.1 0.5 0.9 1.8 1.6 3.3 0.1 18.0 0.7 1.3 0.1 0.4 0.7 18.1 3.1 0.1 0.2 1.0 11.2 1.7 1.8 1.3 0.7 0.8 1.9 1.6 6.3 0.8 1.7 0.9 2.8 0.7 1.0 3.0 2.2 0.0 1.7 0.9 1.4 0.0 0.6 0.0 0.0 0.8 0.0 0.0 0.1 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.2 1.2 1.1 1.3 1.3 1.0 0.8 0.1 1.3 0.1 0.1 2.5 0.5 0.5 0.0 0.5 0.7 0.2 0.1 0.7 4.0 0.6 1.5 1.1 1.1 0.5 0.0 2.4 0.0 0.0 4.2 0.1 1.9 1.9 4.3 641.1 6.4 2.8 0.9 0.0 2.7 1.9 1.6 1.5 0.6 4.6 24.8 0.0 2.2 0.4 0.9 1.4 0.0 1.3 1.4 2.0 1.2 1.3 1415.3 6.8 2.4 0.0 0.0 0.4 0.5 0.0 0.5 0.6 5.2 1.3 3.4 0.1 0.3 0.5 1.5 1.8 1.4 6.6 0.6 0.6 9.2 4.3 2.0 2.3 117.5 1.0 2.2 1.0 2.4 OTUD5 "DKFZp761A052, DUBA" ENSG00000068308 "OTU deubiquitinase 5" Q96G74 X 48922024-48958386 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Group enriched" "Detected in all" 10 "U-266/70: 1503.3;U-266/84: 407.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017375 Approved Approved "Nucleoplasm,Nucleoli fibrillar center,Cytosol" NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 29: U-266 - Adaptive immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Cytosol "Nucleoplasm, Nucleoli fibrillar center" "HPA017375: AB_1854844" "unprognostic (9.73e-2)" "prognostic favorable (9.57e-4)" "unprognostic (2.67e-2)" "unprognostic (7.25e-2)" "unprognostic (1.08e-1)" "unprognostic (6.65e-2)" "unprognostic (2.33e-3)" "prognostic favorable (1.48e-4)" "unprognostic (1.11e-1)" "unprognostic (1.14e-1)" "prognostic favorable (8.20e-4)" "unprognostic (1.32e-1)" "unprognostic (3.60e-1)" "unprognostic (1.19e-1)" "unprognostic (1.10e-1)" "unprognostic (4.88e-2)" "unprognostic (5.05e-3)" 37.7 44.8 42.9 36.9 44.9 56.7 36.6 39.2 45.5 40.6 33.6 45.8 39.6 43.0 29.9 37.5 41.4 24.7 29.9 44.8 46.1 41.1 39.5 39.6 43.4 44.2 42.8 46.8 37.7 35.6 46.1 26.4 46.0 43.1 21.7 30.2 36.3 32.0 39.7 44.6 47.3 27.0 38.3 60.7 37.5 24.2 44.9 47.0 42.3 25.2 35.8 39.9 36.7 43.9 53.0 77.8 36.0 88.9 59.2 52.3 41.4 45.7 52.9 55.9 59.8 39.7 57.3 58.9 29.2 56.8 49.1 63.3 54.2 45.7 51.7 69.1 65.0 44.5 79.4 45.0 49.3 43.4 48.7 58.1 41.2 58.2 39.5 61.4 44.7 47.8 56.9 90.7 40.0 52.3 67.7 89.2 64.9 19.5 60.4 53.0 52.5 77.4 38.9 46.4 34.7 60.7 60.2 38.7 61.7 82.7 51.6 39.2 64.2 36.5 46.2 97.2 38.1 1503.3 407.1 56.5 56.3 58.9 25.7 5.5 3.3 7.6 6.6 5.2 5.6 8.6 5.1 5.7 4.8 5.3 4.8 7.1 8.5 20.3 5.1 6.2 7.3 3.6 42.9 44.9 39.2 45.5 44.8 46.1 44.2 42.8 46.0 38.3 44.9 43.9 21.3 9.6 22.3 17.3 33.3 22.2 21.2 13.7 13.1 35.5 23.7 19.7 11.5 15.7 16.3 27.6 27.1 13.3 38.2 28.4 9.8 13.6 1.9 24.5 23.2 19.6 48.2 32.6 15.5 18.3 16.3 18.4 21.4 33.1 7.0 28.5 22.1 24.3 16.7 28.6 15.7 28.5 10.2 22.9 33.9 2.9 20.8 25.7 26.6 15.9 22.6 18.0 30.9 14.1 14.1 21.5 19.0 23.7 38.1 27.5 28.1 21.7 21.6 27.9 13.1 19.9 20.1 10.4 12.6 15.9 25.6 30.8 33.3 28.6 20.1 27.4 OTUD7A "C15orf16, CEZANNE2, OTUD7" ENSG00000169918 "OTU deubiquitinase 7A" Q8TE49 15 31475398-31870789 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "brain: 20.5" "Cell type enhanced" "Detected in many" "Astrocytes: 135.2;Excitatory neurons: 303.6;Inhibitory neurons: 219.7;Oligodendrocyte precursor cells: 100.0;Oligodendrocytes: 506.1" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AN3-CA: 1.7;HAP1: 1.0;SCLC-21H: 3.6;SH-SY5Y: 1.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044554 Approved Nucleoli,Cytosol NA NA "Cluster 70: Brain - Nervous system development" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Nucleoli, Cytosol" "HPA044554: AB_10794895" "unprognostic (3.61e-2)" "unprognostic (1.35e-3)" "unprognostic (1.39e-1)" "unprognostic (1.25e-3)" "unprognostic (1.29e-1)" "unprognostic (1.03e-4)" "unprognostic (1.50e-1)" "unprognostic (1.21e-1)" "unprognostic (1.38e-1)" "unprognostic (1.67e-1)" "unprognostic (3.24e-3)" "unprognostic (1.34e-1)" "unprognostic (1.79e-11)" "unprognostic (6.78e-2)" "unprognostic (2.76e-1)" "unprognostic (8.27e-2)" "unprognostic (1.79e-1)" 1.2 0.5 6.6 0.4 9.5 0.0 1.0 7.6 8.6 1.3 0.0 1.4 0.3 1.3 0.5 0.7 1.1 0.3 1.3 6.9 5.9 0.9 0.4 0.8 0.4 8.5 6.9 0.9 1.4 1.2 1.5 0.0 8.2 0.6 0.4 1.6 0.7 0.4 1.1 2.6 0.9 0.6 5.6 0.6 0.8 4.1 8.3 0.3 1.0 0.2 0.4 0.8 0.8 20.5 0.0 0.0 0.1 1.7 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.0 0.0 0.0 0.4 0.8 0.0 0.2 0.1 0.0 0.0 0.7 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.5 0.0 0.0 0.3 0.5 0.0 0.0 0.1 3.6 1.8 0.5 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 6.6 9.5 7.6 8.6 6.9 5.9 8.5 6.9 8.2 5.6 8.3 20.5 3.5 3.2 0.0 135.2 0.1 0.4 0.7 0.0 1.8 25.7 1.1 1.3 3.2 0.0 0.6 1.8 2.1 0.0 4.3 1.3 0.0 0.5 1.4 0.4 1.2 1.3 3.6 0.0 303.6 1.0 0.1 1.8 0.5 0.4 0.0 1.0 1.4 0.8 0.2 25.2 219.7 1.7 0.0 0.0 0.3 2.0 0.9 0.3 1.8 28.1 0.2 3.9 13.4 100.0 506.1 0.3 0.7 2.6 2.6 1.9 0.4 1.7 0.0 3.1 0.0 4.1 1.5 4.6 8.3 1.8 0.4 0.1 3.1 0.9 1.5 1.0 OTUD7B "CEZANNE, ZA20D1" ENSG00000264522 "OTU deubiquitinase 7B" Q6GQQ9 1 149937812-150010726 "Enzymes, Predicted intracellular proteins" "Adaptive immunity, Immunity, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 43.0" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 106.3;Oligodendrocytes: 176.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "basophil: 2.0" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027045, HPA076357" Supported Uncertain "Microtubules,Cytokinetic bridge,Mitotic spindle" Yes NA "Cluster 41: Basophils - Cellular respiration" "Cluster 70: Brain - Nervous system development" "Cluster 2: Karpas-707 - Immune response" "Cluster 9: Photoreceptor cells - Phototransduction" Microtubules "Cytokinetic bridge, Mitotic spindle" "HPA027045: AB_1854847, HPA076357: " "unprognostic (2.17e-2)" "unprognostic (2.93e-2)" "unprognostic (1.90e-1)" "prognostic favorable (7.47e-4)" "unprognostic (1.51e-1)" "unprognostic (1.05e-1)" "unprognostic (1.23e-3)" "unprognostic (1.46e-2)" "prognostic favorable (5.09e-5)" "unprognostic (4.90e-2)" "unprognostic (7.72e-2)" "unprognostic (8.94e-2)" "unprognostic (3.37e-2)" "unprognostic (1.67e-2)" "unprognostic (1.18e-1)" "unprognostic (4.52e-2)" "unprognostic (1.58e-2)" 11.7 7.7 21.0 3.8 39.2 1.1 7.8 28.7 18.5 9.9 6.8 7.6 6.2 10.5 3.8 7.7 9.3 4.8 7.1 15.3 22.1 5.6 10.7 7.3 1.9 41.4 37.2 10.9 6.1 10.9 3.4 7.1 35.5 6.6 7.1 10.1 7.8 7.5 18.6 5.8 6.2 10.8 27.9 3.6 6.7 12.7 31.7 2.1 6.7 16.2 3.2 6.3 5.2 43.0 17.2 13.5 9.3 15.6 12.0 11.1 8.8 11.8 17.3 14.0 9.6 10.0 13.6 0.2 7.5 21.7 6.3 13.4 13.2 13.1 14.6 16.5 6.7 6.6 18.9 6.8 12.8 7.6 6.9 12.4 9.9 23.7 20.6 10.9 11.5 2.0 18.4 18.1 10.1 17.5 1.3 2.1 11.9 12.8 13.1 1.8 12.9 4.4 5.4 23.2 6.0 11.4 20.8 15.2 18.5 12.1 12.6 4.0 13.9 14.4 13.2 9.8 14.0 19.1 20.0 2.0 12.8 2.2 24.1 2.0 0.0 0.4 0.7 0.0 0.5 0.1 0.3 0.4 0.0 0.1 0.2 0.3 0.3 0.4 0.0 0.1 0.1 0.0 21.0 39.2 28.7 18.5 15.3 22.1 41.4 37.2 35.5 27.9 31.7 43.0 10.2 35.3 11.7 56.8 3.0 15.9 22.7 8.7 13.1 28.0 18.3 9.3 22.2 12.8 15.3 11.0 106.3 23.5 5.1 41.1 7.9 14.5 63.4 21.8 17.8 16.7 17.4 14.9 20.6 11.1 11.6 14.8 21.4 40.2 0.0 22.0 20.3 33.0 3.1 23.5 24.6 15.8 8.2 0.8 5.9 79.4 14.6 2.4 37.4 22.5 4.3 23.6 15.5 33.2 176.8 20.6 21.3 23.0 4.7 20.2 17.1 11.5 17.4 66.9 0.0 19.8 17.9 11.1 7.2 11.8 16.6 21.2 7.5 11.1 11.1 34.0 OTULIN "FAM105B, FLJ34884" ENSG00000154124 "OTU deubiquitinase with linear linkage specificity" Q96BN8 5 14664664-14699850 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Angiogenesis, Immunity, Innate immunity, Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 26.8" "Cell type enhanced" "Detected in many" "dendritic cells: 70.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA051074 Uncertain Approved "Plasma membrane,Mitochondria" NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 20: HeLa - Mitochondria" "Cluster 24: Non-specific - Transcription regulation" Mitochondria "Plasma membrane" "HPA051074: AB_2681334" "unprognostic (4.81e-3)" "unprognostic (1.11e-1)" "unprognostic (4.00e-2)" "unprognostic (1.19e-2)" "unprognostic (7.48e-2)" "unprognostic (1.91e-2)" "unprognostic (7.94e-3)" "unprognostic (1.43e-1)" "unprognostic (2.48e-2)" "unprognostic (9.55e-2)" "unprognostic (1.02e-1)" "unprognostic (7.13e-2)" "prognostic unfavorable (2.59e-7)" "unprognostic (2.92e-2)" "unprognostic (2.28e-2)" "unprognostic (1.60e-1)" "unprognostic (5.02e-2)" 5.0 3.9 4.8 9.6 6.3 26.8 4.6 5.9 4.9 5.5 6.2 4.7 7.6 3.6 2.6 8.0 3.5 4.7 6.7 4.9 5.0 4.4 12.3 6.4 12.5 6.6 5.6 4.8 6.8 3.8 3.6 6.5 6.4 6.3 4.6 4.6 5.7 3.3 5.2 11.8 5.8 4.8 5.6 7.1 4.3 7.1 5.8 11.2 4.1 5.5 13.5 5.7 6.9 7.1 10.0 11.5 11.2 12.8 10.0 10.3 12.3 9.8 6.9 13.8 10.2 15.4 7.2 18.0 18.9 6.4 19.9 11.1 14.1 12.9 9.2 31.1 11.6 12.9 36.3 8.3 8.8 12.4 21.2 6.0 15.2 11.3 9.4 7.6 11.8 14.9 13.0 27.8 10.0 6.1 12.4 10.6 6.9 10.5 12.0 18.8 10.0 7.1 8.9 10.1 5.1 8.3 35.1 7.8 7.6 13.5 8.5 14.1 11.1 17.8 20.0 13.4 13.2 12.4 20.6 20.3 10.1 23.2 9.3 0.2 0.6 1.1 0.3 0.7 1.0 0.3 0.8 1.1 1.0 1.6 0.5 1.3 0.7 0.3 1.1 0.8 1.7 0.3 4.8 6.3 5.9 4.9 4.9 5.0 6.6 5.6 6.4 5.6 5.8 7.1 20.3 3.2 11.5 23.5 24.6 0.0 23.2 0.0 26.2 11.9 12.8 11.7 15.0 10.0 4.3 5.5 14.6 15.1 70.6 21.1 7.9 5.5 9.4 20.6 28.1 13.3 9.5 13.7 18.5 5.8 10.3 10.1 16.8 24.0 10.2 14.0 6.4 36.9 13.9 8.4 19.5 15.7 0.0 18.9 0.0 4.2 10.5 25.0 0.0 38.4 17.1 10.4 26.8 16.6 31.7 8.0 13.3 6.4 38.5 25.9 14.1 15.1 5.1 31.4 0.0 11.5 10.2 29.7 28.8 23.7 0.0 14.2 35.8 7.6 15.6 23.1 OTULINL "FAM105A, FLJ11127, NET20" ENSG00000145569 "OTU deubiquitinase with linear linkage specificity like" Q9NUU6 5 14581792-14616180 "Enzymes, Predicted membrane proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 30.3" "Cell type enhanced" "Detected in some" "Collecting duct cells: 29.5;dendritic cells: 36.7;Endometrial stromal cells: 16.6;Hofbauer cells: 100.7;Macrophages: 28.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HeLa: 17.7;HMC-1: 55.6;OE19: 16.1;THP-1: 16.9;U-937: 27.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046638 Uncertain Approved Nucleoli,Cytosol NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" "Nucleoli, Cytosol" "HPA046638: AB_2679731" "unprognostic (1.47e-1)" "unprognostic (6.64e-3)" "unprognostic (1.92e-2)" "unprognostic (1.15e-3)" "unprognostic (6.26e-2)" "unprognostic (1.13e-3)" "unprognostic (2.33e-2)" "unprognostic (2.27e-2)" "unprognostic (6.44e-2)" "unprognostic (2.42e-1)" "prognostic favorable (1.02e-4)" "unprognostic (2.13e-1)" "unprognostic (1.33e-2)" "unprognostic (2.38e-2)" "prognostic unfavorable (7.62e-4)" "unprognostic (3.14e-1)" "unprognostic (8.79e-3)" 3.1 2.7 1.2 6.8 1.1 30.3 4.1 1.3 1.6 3.8 4.8 12.3 6.6 1.5 1.4 1.7 1.4 2.7 0.9 1.1 1.8 3.6 1.4 13.1 5.4 2.3 1.5 2.0 7.6 1.2 2.5 4.2 2.1 8.3 13.3 0.5 1.4 10.0 0.4 1.7 9.4 2.5 2.4 7.9 3.3 2.5 1.9 3.4 2.8 0.8 3.6 5.2 3.1 3.6 0.0 0.8 1.6 0.0 0.3 0.0 6.9 2.0 1.8 0.5 1.0 2.8 1.7 0.1 1.1 0.9 2.8 0.1 3.7 1.6 0.7 1.1 4.9 4.6 17.7 0.4 1.7 0.1 55.6 0.1 0.3 0.2 0.0 0.0 0.1 2.9 0.0 7.1 0.2 1.4 0.0 1.7 2.5 16.1 11.9 0.5 0.7 2.0 0.0 13.9 6.0 7.0 0.9 0.6 0.0 1.7 0.6 16.9 0.0 0.9 4.4 0.4 1.6 0.0 0.0 0.1 1.0 27.2 0.4 0.2 33.4 0.3 5.5 16.2 7.3 0.1 6.7 7.2 33.8 0.1 9.0 9.1 8.6 19.2 12.7 25.0 12.8 24.6 1.2 1.1 1.3 1.6 1.1 1.8 2.3 1.5 2.1 2.4 1.9 3.6 10.2 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 7.4 7.9 0.0 0.0 0.0 29.5 0.0 0.9 36.7 0.0 1.9 0.4 0.0 0.9 16.6 1.1 0.0 0.0 0.0 6.2 2.2 1.4 0.0 1.2 0.0 0.5 0.0 0.0 100.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 28.3 0.0 0.0 12.9 0.0 0.0 0.0 0.0 1.2 0.0 0.0 4.4 0.0 0.0 3.5 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 1.4 8.8 0.2 0.0 0.0 OVCH1 OVCH ENSG00000187950 "Ovochymase 1" Q7RTY7 12 29412474-29497686 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "lung: 4.5;testis: 2.4" "Group enriched" "Detected in some" 5 "Excitatory neurons: 14.3;Inhibitory neurons: 14.9" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "Daudi: 5.5" "Low region specificity" "Detected in many" "Secreted in other tissues" NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (3.32e-1)" "unprognostic (2.20e-1)" "unprognostic (2.03e-1)" "unprognostic (1.56e-5)" "unprognostic (1.68e-1)" "unprognostic (1.58e-1)" "unprognostic (4.41e-2)" "unprognostic (1.83e-1)" "unprognostic (2.25e-2)" "unprognostic (5.46e-2)" "unprognostic (1.36e-1)" "unprognostic (5.48e-2)" "unprognostic (5.59e-3)" "unprognostic (1.04e-1)" "unprognostic (2.14e-1)" "unprognostic (3.52e-2)" "unprognostic (2.06e-1)" 0.2 0.2 0.7 0.3 1.2 0.1 0.2 0.0 1.2 0.2 0.0 0.1 0.0 0.1 0.0 0.1 0.1 0.2 0.2 0.9 0.5 0.1 0.2 4.5 0.1 0.0 0.6 0.2 0.0 0.0 0.2 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.3 0.1 0.0 0.1 0.6 0.1 2.4 0.7 0.0 1.0 0.0 0.0 0.1 0.1 0.5 0.0 0.0 0.3 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.3 0.0 0.1 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.7 1.2 0.0 1.2 0.9 0.5 0.0 0.6 0.1 0.1 0.7 0.5 0.7 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.1 0.1 0.7 0.0 0.0 14.3 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 14.9 0.0 0.0 0.0 0.0 2.7 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.5 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 PA2G4 ENSG00000170515 "Proliferation-associated 2G4" Q9UQ80 12 56104537-56113910 "Enzymes, Plasma proteins, Predicted intracellular proteins" "rRNA processing, Transcription, Transcription regulation, Translation regulation" "Repressor, Ribonucleoprotein, RNA-binding" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011711, CAB012428, HPA016484" Supported Approved Cytosol NA NA 2300000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Cytosol "CAB011711: AB_732060, CAB012428: , HPA016484: AB_1854912" "unprognostic (5.53e-2)" "unprognostic (1.06e-1)" "unprognostic (2.35e-2)" "unprognostic (2.34e-2)" "unprognostic (3.87e-1)" "unprognostic (6.03e-3)" "prognostic unfavorable (6.31e-7)" "unprognostic (4.25e-3)" "unprognostic (2.77e-1)" "unprognostic (3.79e-3)" "unprognostic (2.29e-2)" "unprognostic (1.30e-2)" "prognostic unfavorable (4.59e-7)" "unprognostic (1.17e-1)" "unprognostic (2.01e-1)" "unprognostic (1.32e-1)" "unprognostic (4.67e-2)" 78.4 59.6 46.7 89.3 50.4 132.9 76.2 50.7 58.0 64.8 43.0 78.7 74.1 64.7 48.2 132.5 64.7 43.7 76.9 48.6 51.8 62.1 72.8 62.5 96.6 49.4 48.3 71.2 75.1 83.7 36.3 69.2 51.0 53.2 90.5 38.3 63.9 55.4 144.0 106.1 69.7 68.4 49.8 61.2 65.5 63.1 48.9 123.4 61.4 92.5 120.7 105.3 76.9 57.2 429.6 374.8 248.9 275.5 112.5 169.8 499.6 441.3 209.7 530.9 293.8 464.7 307.5 850.8 291.2 209.6 155.9 343.5 574.2 493.1 510.9 243.9 517.6 659.1 242.5 400.4 219.7 898.8 232.4 172.5 247.2 460.2 410.8 218.1 327.3 292.0 812.8 380.7 294.7 383.5 700.8 496.2 410.9 264.5 460.9 569.3 449.8 577.2 272.0 315.7 372.8 225.6 290.5 451.6 275.0 183.1 488.7 343.5 264.8 256.3 364.7 300.3 495.5 234.4 345.1 822.1 232.3 532.6 340.9 34.3 87.0 54.6 129.9 96.0 174.7 98.0 136.8 141.3 102.1 81.3 129.7 131.2 13.8 151.5 82.0 98.6 170.9 155.9 46.7 50.4 50.7 58.0 48.6 51.8 49.4 48.3 51.0 49.8 48.9 57.2 135.7 54.5 91.2 9.8 136.3 368.5 244.7 187.4 224.8 56.2 151.9 165.7 37.3 118.7 161.3 130.6 18.8 232.0 163.1 123.4 193.7 235.8 530.6 127.1 218.4 154.2 93.3 552.1 12.8 249.1 321.7 139.5 112.7 142.2 170.9 103.7 107.8 197.5 208.6 33.7 13.0 159.0 99.7 124.2 127.8 238.9 132.0 126.2 129.9 6.5 155.4 117.1 178.2 10.6 14.8 269.3 100.8 126.7 163.5 360.7 118.6 264.7 103.6 48.8 144.7 188.1 191.7 344.6 110.9 295.2 362.7 193.5 176.2 132.2 254.1 242.7 PAMR1 "DKFZP586H2123, RAMP" ENSG00000149090 "Peptidase domain containing associated with muscle regeneration 1" Q6UXH9 11 35431823-35530300 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Serine protease homolog" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in many" 7 "Astrocytes: 380.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC diff: 86.9;ASC TERT1: 354.7;BJ hTERT+: 357.7;fHDF/TERT166: 86.7;HSkMC: 123.1;U-87 MG: 82.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "Secreted - unknown location" NA NA 5600000 "Cluster 57: Non-specific - Angiogenesis" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 64: Astrocytes - Nervous system maintenance" "unprognostic (3.38e-1)" "unprognostic (1.07e-2)" "unprognostic (1.67e-1)" "unprognostic (1.00e-3)" "unprognostic (6.50e-3)" "unprognostic (1.01e-1)" "unprognostic (2.07e-2)" "unprognostic (6.92e-2)" "unprognostic (3.32e-2)" "unprognostic (4.07e-2)" "unprognostic (1.91e-2)" "unprognostic (1.36e-2)" "prognostic unfavorable (5.08e-5)" "prognostic unfavorable (6.29e-4)" "unprognostic (2.08e-1)" "unprognostic (9.98e-2)" "unprognostic (8.25e-2)" 32.8 14.9 25.1 0.6 27.4 0.0 15.4 22.0 23.2 59.9 13.9 14.9 4.5 58.2 18.3 10.0 22.6 20.3 23.2 22.5 26.2 7.1 12.6 5.9 1.3 37.9 35.9 3.4 5.3 1.7 6.4 55.9 32.4 21.2 6.6 0.9 5.7 17.9 2.7 19.8 9.9 14.9 46.1 5.7 5.4 0.2 34.1 2.8 7.0 9.0 1.7 28.0 41.3 38.8 0.0 0.0 0.1 0.0 86.9 354.7 0.1 42.8 357.7 4.9 8.3 32.7 0.0 0.0 0.0 86.7 0.1 0.1 0.0 0.0 3.3 0.0 0.8 0.0 0.0 0.0 50.1 0.0 0.0 123.1 1.8 9.7 1.3 0.1 0.0 0.0 0.0 0.1 0.3 0.1 0.0 0.1 0.7 0.0 0.2 0.0 0.2 0.2 0.0 8.4 0.1 0.0 0.0 0.0 0.0 14.3 2.0 0.0 0.0 0.0 1.1 0.1 0.0 0.0 0.1 0.0 82.6 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 25.1 27.4 22.0 23.2 22.5 26.2 37.9 35.9 32.4 46.1 34.1 38.8 2.5 0.0 0.0 380.3 0.0 19.1 1.4 14.8 1.2 0.1 0.7 19.7 1.3 0.0 2.4 1.8 0.0 2.2 0.0 0.0 0.0 1.4 0.1 4.5 26.2 1.1 0.0 0.0 13.1 0.0 1.4 50.2 1.1 0.8 0.0 0.6 0.0 0.0 2.0 0.0 8.2 0.2 0.0 0.0 5.5 0.1 0.3 0.5 1.8 28.1 0.6 0.0 0.0 9.5 1.4 0.1 0.0 0.0 0.0 0.4 0.2 0.0 1.8 0.2 0.0 1.6 5.8 0.0 0.2 0.1 9.2 3.4 0.6 0.2 0.0 0.2 PAN2 "hPAN2, KIAA0710, USP52" ENSG00000135473 "Poly(A) specific ribonuclease subunit PAN2" Q504Q3 12 56316223-56334053 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "mRNA processing" "Exonuclease, Hydrolase, Nuclease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 23: Testis - Cell cycle regulation" "Cluster 30: Epithelial cell lines - Translation" "Cluster 52: Non-specific - Transcription" "unprognostic (2.43e-1)" "unprognostic (3.78e-1)" "unprognostic (1.21e-2)" "unprognostic (2.55e-1)" "unprognostic (1.67e-1)" "unprognostic (9.10e-3)" "unprognostic (1.03e-1)" "unprognostic (7.28e-2)" "unprognostic (7.35e-3)" "unprognostic (3.80e-1)" "unprognostic (1.74e-3)" "unprognostic (4.23e-3)" "prognostic unfavorable (2.77e-4)" "unprognostic (4.19e-1)" "unprognostic (3.87e-1)" "unprognostic (2.10e-1)" "unprognostic (2.68e-2)" 6.6 8.7 4.2 5.8 6.1 7.4 7.4 6.0 6.0 8.3 6.9 8.0 9.9 9.1 14.1 5.0 9.7 6.6 7.1 4.1 4.5 7.6 16.0 7.3 8.5 5.3 5.2 12.7 10.0 14.1 11.6 8.2 5.4 6.7 8.2 16.0 7.9 8.2 6.9 8.3 8.7 7.5 4.7 10.1 9.5 13.5 5.7 16.8 14.8 6.7 10.0 7.0 6.7 7.9 4.3 6.4 15.5 4.9 13.3 15.0 10.1 3.2 4.4 7.1 3.2 3.9 8.3 11.8 12.2 6.3 3.8 8.8 18.6 12.3 4.0 5.2 8.8 15.1 6.6 3.8 11.7 3.3 7.8 14.0 16.3 7.6 22.0 18.7 5.4 24.2 10.3 28.4 4.2 9.4 11.3 7.9 5.2 7.2 4.2 9.7 11.0 21.5 7.0 3.4 12.1 11.0 6.2 7.9 8.0 17.2 10.2 6.4 2.3 7.0 7.0 3.3 3.0 23.9 10.3 7.8 8.7 6.8 6.2 3.2 3.3 1.3 1.3 4.4 1.9 1.6 1.1 1.9 4.2 1.3 2.2 2.7 0.2 2.3 2.2 1.7 1.7 2.0 4.2 6.1 6.0 6.0 4.1 4.5 5.3 5.2 5.4 4.7 5.7 7.9 9.7 9.6 17.0 19.2 11.1 5.1 5.4 3.8 6.8 27.4 9.5 10.2 9.8 2.8 8.3 5.5 27.1 8.2 7.9 5.4 1.9 3.7 1.8 8.6 9.4 9.4 14.4 13.3 11.0 2.2 4.8 7.2 18.3 13.7 6.3 15.0 10.4 18.3 5.4 15.2 13.9 10.8 4.1 7.0 5.0 2.6 11.1 8.2 1.8 9.4 5.2 7.3 3.1 10.1 32.1 2.8 8.7 6.4 9.2 4.1 7.3 3.5 13.4 17.1 6.6 11.4 6.9 26.9 7.6 7.1 3.8 5.1 6.6 12.6 9.5 3.6 PAPPA "ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1" ENSG00000182752 "Pappalysin 1" Q13219 9 116153791-116402321 "Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "placenta: 72.3" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 92.2;Collecting duct cells: 165.5;Endometrial stromal cells: 101.3;Proximal tubular cells: 51.5" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 50.0;ASC TERT1: 37.8;HSkMC: 137.4;U-138 MG: 36.3" "Low region specificity" "Detected in single" "Low region specificity" "Detected in many" "HPA001667, CAB016724" Enhanced "Secreted in female reproductive system" NA NA 78000000 "Cluster 28: Placenta - Pregnancy" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 36: Stromal cells - Cell proliferation" "CAB016724: , HPA001667: AB_1854960" "unprognostic (3.25e-1)" "unprognostic (6.18e-6)" "unprognostic (2.47e-1)" "unprognostic (6.49e-2)" "unprognostic (2.01e-2)" "unprognostic (1.14e-1)" "unprognostic (1.13e-1)" "unprognostic (5.42e-3)" "unprognostic (5.44e-2)" "unprognostic (3.87e-2)" "unprognostic (6.87e-3)" "unprognostic (8.25e-2)" "unprognostic (8.00e-3)" "unprognostic (2.37e-3)" "unprognostic (2.48e-1)" "unprognostic (4.01e-1)" "unprognostic (1.02e-3)" 4.1 1.5 0.7 1.8 0.2 0.0 0.8 0.5 0.9 4.2 2.2 2.0 0.3 3.9 0.6 2.5 3.1 2.0 2.6 0.3 1.6 3.8 0.3 1.9 1.2 2.5 2.5 2.5 0.8 9.1 0.4 72.3 2.0 1.1 1.5 1.0 0.4 2.1 0.3 0.9 0.9 4.2 0.4 0.3 1.1 0.8 1.6 0.8 1.0 1.4 1.0 4.5 2.4 1.3 0.0 14.9 22.3 0.0 50.0 37.8 0.0 12.2 21.4 3.3 5.6 0.0 0.0 0.0 0.0 8.6 1.1 1.7 0.0 0.0 15.6 0.0 0.0 2.6 12.8 0.1 24.3 0.0 0.0 137.4 0.0 16.4 1.9 26.9 0.1 0.0 0.5 0.0 3.8 0.0 0.0 0.0 6.5 0.0 0.0 0.0 0.6 0.0 0.6 0.1 0.1 1.2 1.8 0.0 0.0 6.8 0.0 0.0 28.9 36.3 1.8 1.0 1.4 0.0 0.0 0.0 25.8 0.0 11.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.2 0.5 0.9 0.3 1.6 2.5 2.5 2.0 0.4 1.6 1.3 0.2 0.0 1.5 3.9 1.0 2.9 0.2 4.0 92.2 17.6 0.8 0.4 3.4 0.0 1.6 165.5 12.5 0.5 0.1 0.1 9.8 5.9 20.1 4.7 101.3 1.4 0.0 0.0 10.0 0.9 19.5 31.8 0.5 2.6 1.3 10.4 4.6 0.1 0.4 0.0 19.6 0.0 0.0 0.0 5.8 17.9 14.3 1.0 1.8 7.5 0.0 2.5 1.0 15.1 2.9 0.3 0.0 8.6 1.2 1.2 0.2 51.5 1.6 2.9 0.0 3.3 10.9 2.2 0.6 19.7 1.1 14.0 1.3 0.2 0.1 0.3 PAPPA2 "PAPP-A2, PAPPE, PLAC3" ENSG00000116183 "Pappalysin 2" Q9BXP8 1 176463171-176845601 "Enzymes, Predicted membrane proteins, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 9 "placenta: 56.8" "Cell type enhanced" "Detected in some" "Enteroendocrine cells: 140.7;Extravillous trophoblasts: 71.9;Muller glia cells: 41.4;Oligodendrocytes: 37.6;Syncytiotrophoblasts: 74.0" "Cancer enhanced" "Detected in some" "pancreatic cancer: 1.8;renal cancer: 1.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "U-87 MG: 19.8" "Low region specificity" "Detected in some" "Region enhanced" "Detected in some" "cerebellum: 5.6" "HPA018412, HPA018430" Enhanced Approved "Endoplasmic reticulum,Vesicles" "Secreted in female reproductive system" NA NA 2000000 "Cluster 28: Placenta - Pregnancy" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 17: Intestinal endocrine cells - Hormone signaling" "Endoplasmic reticulum, Vesicles" "HPA018412: AB_1854962, HPA018430: AB_1854961" "unprognostic (2.90e-1)" "unprognostic (1.58e-1)" "unprognostic (1.07e-1)" "unprognostic (3.61e-2)" "unprognostic (9.04e-2)" "unprognostic (1.60e-3)" "unprognostic (1.36e-1)" "unprognostic (2.45e-1)" "unprognostic (1.00e-2)" "unprognostic (3.54e-2)" "unprognostic (1.29e-2)" "unprognostic (4.39e-2)" "unprognostic (2.85e-2)" "unprognostic (1.52e-4)" "unprognostic (1.85e-1)" "unprognostic (8.18e-4)" "unprognostic (4.35e-2)" 0.6 0.0 0.5 0.3 0.3 0.0 2.5 0.3 0.4 6.6 0.0 0.6 0.0 0.6 0.3 0.0 0.2 1.8 0.3 0.5 0.2 6.3 0.6 0.1 0.0 0.5 0.5 0.0 2.5 0.0 1.1 56.8 0.6 0.2 0.5 3.7 0.1 0.6 0.0 0.1 0.2 0.5 0.4 0.0 1.6 0.4 0.3 0.0 0.5 0.0 0.0 0.3 0.2 0.4 0.0 0.0 0.0 0.0 0.2 0.7 0.0 0.1 0.3 0.0 0.5 0.0 0.0 0.0 0.1 0.8 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 1.2 4.3 2.1 3.5 0.9 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.7 0.5 0.5 0.2 0.0 0.0 0.1 0.7 0.0 0.0 0.3 1.6 1.3 0.1 0.6 0.3 0.4 0.0 19.8 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.3 0.3 0.4 0.5 0.2 0.5 0.5 0.6 0.4 0.3 0.4 0.0 0.0 0.0 26.1 0.0 0.0 0.0 0.0 0.0 6.1 0.0 0.1 0.8 0.0 0.0 5.5 0.0 1.5 0.0 0.1 11.7 0.0 2.6 0.2 0.1 0.3 140.7 0.0 16.3 0.2 71.9 0.8 0.0 0.0 0.0 0.0 0.0 0.6 1.3 0.0 10.8 0.2 0.0 0.0 0.0 1.9 11.5 0.0 0.0 2.8 0.0 41.4 0.0 5.0 37.6 0.8 0.0 10.9 0.0 0.0 0.0 0.5 0.0 2.4 6.6 0.0 1.2 1.3 2.2 0.0 0.0 74.0 0.0 0.0 0.2 0.1 PARK7 "DJ-1, DJ1, GATD2" ENSG00000116288 "Parkinsonism associated deglycase" Q99497 1 7954291-7985505 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, DNA damage, DNA repair, Fertilization, Inflammatory response, Stress response" "Chaperone, Hydrolase, Protease, RNA-binding" "Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004190, CAB005870" Supported Supported Nucleoplasm,Cytosol NA NA 35000000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Cytosol" "CAB005870: AB_444361, HPA004190: AB_1079566" "unprognostic (6.88e-3)" "unprognostic (7.50e-2)" "unprognostic (3.48e-2)" "unprognostic (1.16e-2)" "unprognostic (4.08e-2)" "unprognostic (5.68e-2)" "unprognostic (7.45e-2)" "unprognostic (9.63e-2)" "unprognostic (2.01e-1)" "unprognostic (1.66e-2)" "unprognostic (1.12e-1)" "unprognostic (2.02e-1)" "unprognostic (1.96e-3)" "unprognostic (8.17e-2)" "unprognostic (1.32e-1)" "unprognostic (1.30e-1)" "unprognostic (7.43e-2)" 249.4 373.6 283.5 213.7 290.0 205.0 235.7 292.9 403.4 201.1 327.7 252.5 145.8 212.2 278.0 161.0 203.2 162.9 388.0 285.5 296.6 311.0 397.6 181.6 269.2 289.6 286.0 234.2 308.5 387.6 283.6 174.1 291.7 234.9 194.9 273.8 240.9 185.6 771.4 127.1 170.5 199.1 295.2 188.2 234.2 139.6 288.1 217.9 286.3 541.8 249.7 226.5 171.2 299.7 537.0 452.5 467.1 523.2 459.8 442.6 218.4 476.7 434.4 450.4 360.3 419.9 549.4 633.1 534.2 505.1 328.6 367.1 483.2 625.3 579.3 574.5 526.2 683.0 678.6 674.5 403.8 662.9 418.6 421.3 262.4 459.8 547.4 359.2 478.2 340.1 676.8 471.7 633.0 485.0 474.3 868.7 376.1 653.6 465.4 366.7 598.0 888.7 714.7 269.7 527.7 447.4 470.4 728.0 798.4 370.1 414.9 503.7 459.3 412.8 344.6 395.5 539.5 452.8 788.4 938.8 551.5 1002.9 606.4 298.4 590.2 394.0 484.7 553.7 459.2 483.6 478.2 577.3 717.4 374.6 406.8 466.8 202.5 551.1 456.9 1378.2 874.4 1060.8 283.5 290.0 292.9 403.4 285.5 296.6 289.6 286.0 291.7 295.2 288.1 299.7 243.6 131.4 157.1 23.2 211.8 208.9 402.4 677.7 200.9 196.2 342.0 381.8 453.3 257.4 318.5 248.3 79.2 553.0 382.3 131.1 851.0 504.3 32.1 272.1 263.9 241.7 238.0 177.1 19.5 478.4 612.1 302.3 146.3 195.9 206.5 291.2 183.1 368.1 435.1 186.7 22.9 279.6 484.2 204.5 304.5 53.6 358.2 258.9 359.3 21.5 605.4 816.4 327.5 18.1 36.0 378.9 186.9 378.7 269.7 523.4 227.1 941.5 327.8 235.5 276.1 277.8 342.6 288.2 302.2 220.4 143.8 469.6 244.4 535.3 312.2 433.1 PARL "PRO2207, PSARL, PSARL1, RHBDS1" ENSG00000175193 "Presenilin associated rhomboid like" Q9H300 3 183829271-183884933 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" HPA019545 Approved Approved Mitochondria NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Mitochondria "HPA019545: AB_1855796" "unprognostic (2.10e-1)" "unprognostic (1.53e-3)" "unprognostic (5.88e-2)" "unprognostic (1.17e-2)" "unprognostic (5.76e-2)" "unprognostic (9.55e-2)" "unprognostic (3.17e-3)" "unprognostic (8.97e-2)" "unprognostic (1.81e-1)" "unprognostic (3.62e-3)" "unprognostic (1.52e-1)" "unprognostic (2.13e-2)" "unprognostic (4.28e-2)" "unprognostic (5.49e-2)" "unprognostic (2.58e-1)" "unprognostic (1.73e-1)" "prognostic favorable (9.11e-5)" 38.4 35.8 46.5 26.6 48.2 33.8 40.3 47.4 66.2 33.8 50.7 47.7 29.2 31.9 57.7 36.7 30.2 19.7 54.1 46.6 48.2 39.6 45.0 28.4 32.0 47.7 48.7 31.7 49.9 39.7 32.0 25.5 47.4 37.1 41.9 32.7 40.5 30.3 54.9 37.1 34.7 29.7 47.2 36.2 42.6 26.7 47.6 34.5 31.4 51.6 33.8 38.9 31.5 48.4 115.1 55.6 39.7 33.0 38.8 42.1 80.2 39.2 59.4 80.5 65.0 172.0 59.0 47.8 90.0 56.7 73.5 49.2 64.1 68.0 90.0 71.6 76.1 73.9 35.5 96.9 57.3 73.9 61.6 60.0 85.4 58.0 70.7 38.5 59.0 82.4 42.6 45.0 69.2 131.0 148.3 194.3 105.5 100.6 53.3 64.7 72.8 92.0 79.0 97.6 37.9 52.0 47.6 162.9 107.8 48.1 159.2 143.5 31.8 29.3 63.0 60.9 108.2 89.2 65.7 116.0 56.6 75.1 35.5 97.5 143.1 133.4 51.3 107.8 60.9 62.4 57.3 59.9 132.4 59.1 68.7 54.2 41.3 67.1 83.3 79.7 73.7 116.1 46.5 48.2 47.4 66.2 46.6 48.2 47.7 48.7 47.4 47.2 47.6 48.4 30.3 22.4 19.7 17.9 37.6 30.3 54.9 93.5 26.7 35.9 31.8 31.5 41.2 35.8 44.5 31.3 31.3 58.9 38.4 24.4 117.4 63.9 24.0 15.2 18.3 30.2 33.7 23.3 23.4 84.7 49.0 35.1 28.1 13.7 69.8 33.1 33.2 30.4 77.7 33.7 24.1 42.0 77.3 56.2 55.7 9.7 28.9 57.5 42.7 33.7 79.3 55.9 50.4 17.1 28.0 60.3 35.1 27.1 42.3 55.4 47.3 86.0 30.5 51.1 6.6 44.8 96.6 47.8 47.4 40.2 30.0 42.1 40.9 49.0 49.2 58.8 PCSK1 "NEC1, PC1, PC3, SPC3" ENSG00000175426 "Proprotein convertase subtilisin/kexin type 1" P29120 5 96390333-96434143 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Disease variant, Obesity" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "brain: 68.3" "Cell type enriched" "Detected in some" 4 "Enteroendocrine cells: 224.6" "Cancer enhanced" "Detected in many" "breast cancer: 12.1" "Group enriched" "Detected in all" 5 "cerebral cortex: 19.1;hypothalamus: 68.3;pons: 30.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "SCLC-21H: 22.6;U-138 MG: 19.0;U-87 MG: 15.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA048564, HPA079656" Approved "Secreted in other tissues" NA NA "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 17: Intestinal endocrine cells - Hormone signaling" "HPA048564: AB_2680444, HPA079656: " "unprognostic (1.86e-2)" "unprognostic (2.13e-2)" "unprognostic (4.66e-3)" "unprognostic (8.20e-5)" "prognostic unfavorable (9.13e-5)" "unprognostic (8.47e-4)" "unprognostic (1.46e-1)" "unprognostic (5.84e-3)" "unprognostic (4.71e-1)" "unprognostic (3.07e-3)" "unprognostic (1.89e-3)" "unprognostic (1.01e-1)" "unprognostic (7.90e-6)" "unprognostic (5.25e-2)" "unprognostic (9.96e-2)" "unprognostic (1.33e-3)" "unprognostic (9.37e-3)" 1.7 6.3 5.5 4.7 3.7 0.1 1.4 1.0 19.1 0.9 0.0 2.4 5.2 0.1 0.0 0.1 0.2 0.2 0.8 3.0 68.3 0.4 0.0 0.3 0.1 6.6 7.7 0.4 7.6 0.0 12.1 0.0 30.0 0.4 2.3 8.7 2.7 0.1 0.3 1.1 3.6 0.6 4.0 0.1 5.7 0.1 6.6 0.2 1.9 0.0 0.0 2.0 0.5 5.3 0.0 0.0 0.3 0.0 2.3 0.7 0.0 0.3 0.2 0.0 0.0 0.0 0.1 0.0 0.1 1.0 3.8 0.0 0.0 0.1 0.0 0.1 0.1 0.8 2.4 0.0 0.0 0.0 0.0 2.0 1.0 0.4 0.1 0.2 0.9 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 22.6 0.0 3.3 0.0 0.0 0.4 0.0 0.0 1.2 19.0 0.6 0.3 0.2 0.0 0.0 0.1 15.8 0.0 0.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.5 3.7 1.0 19.1 3.0 68.3 6.6 7.7 30.0 4.0 6.6 5.3 0.0 0.0 0.0 3.6 0.0 0.0 0.1 0.0 1.8 13.2 0.0 0.0 0.7 0.0 0.0 0.0 2.1 0.0 0.0 0.8 0.0 0.0 0.4 0.0 0.2 0.2 224.6 0.0 54.5 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 4.0 10.7 2.0 0.0 0.4 1.6 0.0 0.0 0.0 4.7 0.0 0.5 0.0 3.5 4.9 1.5 0.1 0.0 0.0 0.3 0.2 0.0 0.0 0.9 0.0 1.7 1.0 0.1 0.1 0.2 0.0 0.1 0.0 0.0 0.7 0.0 PCSK2 "NEC2, PC2, SPC2" ENSG00000125851 "Proprotein convertase subtilisin/kexin type 2" P16519 20 17226107-17484578 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 28.5;brain: 30.2;retina: 35.8;thyroid gland: 56.9" "Cell type enhanced" "Detected in many" "Early spermatids: 87.3;Excitatory neurons: 322.8;Horizontal cells: 132.9;Inhibitory neurons: 148.8;Melanocytes: 209.9;Muller glia cells: 452.7" "Cancer enriched" "Detected in many" 4 "thyroid cancer: 65.1" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "AF22: 60.0;SCLC-21H: 15.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049627 Approved Approved Vesicles "Secreted in other tissues" NA NA 18000 "Cluster 41: Basophils - Cellular respiration" "Cluster 58: Brain - Synaptic function" "Cluster 12: NES - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Vesicles "HPA049627: AB_2680835" "unprognostic (2.03e-3)" "unprognostic (1.61e-1)" "unprognostic (3.13e-1)" "unprognostic (2.18e-1)" "unprognostic (2.13e-1)" "unprognostic (6.84e-2)" "unprognostic (3.07e-3)" "unprognostic (4.31e-1)" "unprognostic (5.88e-2)" "unprognostic (2.50e-3)" "unprognostic (2.14e-1)" "unprognostic (7.26e-5)" "unprognostic (2.29e-1)" "unprognostic (1.57e-1)" "unprognostic (2.35e-1)" "unprognostic (1.14e-1)" 0.7 28.5 8.6 0.8 14.9 0.5 0.4 0.1 30.2 1.6 0.0 6.9 4.8 0.2 0.3 1.1 1.0 0.5 4.7 15.8 11.1 0.2 0.2 2.5 0.0 2.2 1.3 9.0 19.8 0.8 2.0 0.6 2.6 1.4 1.7 35.8 1.7 1.2 0.1 14.1 2.1 0.4 1.4 0.1 8.1 4.8 13.2 0.0 56.9 0.1 0.1 3.0 2.4 11.9 0.0 0.0 60.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 8.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.7 0.2 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.2 0.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.5 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.6 14.9 0.1 30.2 15.8 11.1 2.2 1.3 2.6 1.4 13.2 11.9 0.1 0.0 7.3 7.8 0.0 8.2 0.0 0.0 1.2 28.1 0.0 0.0 1.2 0.0 0.6 0.0 6.2 0.0 0.0 0.0 0.0 0.0 87.3 0.0 0.0 1.3 0.0 0.0 322.8 0.0 0.0 1.2 0.0 0.0 0.0 0.0 4.6 0.0 0.0 132.9 148.8 0.6 0.0 0.0 1.3 6.3 2.8 0.2 209.9 8.4 0.0 452.7 0.0 44.7 6.4 2.8 2.5 0.0 0.0 0.0 0.0 0.0 0.0 14.4 0.0 0.5 1.2 1.0 0.3 0.2 1.4 0.0 0.1 0.6 0.0 0.1 PCSK4 "DKFZp434B217, MGC34749, PC4, SPC5" ENSG00000115257 "Proprotein convertase subtilisin/kexin type 4" Q6UW60 19 1481428-1490752 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 9 "testis: 66.0" "Group enriched" "Detected in many" 4 "Early spermatids: 277.1;Late spermatids: 679.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AN3-CA: 6.7;HMC-1: 3.7;JURKAT: 5.3;U-266/70: 7.7" "Not detected" "Not detected" "Not detected" "Not detected" HPA005572 Uncertain NA NA "Cluster 83: Testis - Spermatogenesis" "Cluster 29: U-266 - Adaptive immune response" "Cluster 25: Spermatids - Spermatogenesis" "HPA005572: AB_1855087" "unprognostic (1.00e-2)" "unprognostic (9.12e-2)" "unprognostic (2.36e-3)" "prognostic favorable (9.45e-5)" "unprognostic (5.23e-2)" "unprognostic (6.14e-2)" "unprognostic (1.78e-1)" "unprognostic (6.34e-3)" "unprognostic (2.94e-1)" "unprognostic (8.29e-3)" "unprognostic (1.93e-2)" "unprognostic (7.44e-2)" "unprognostic (6.56e-2)" "unprognostic (3.82e-2)" "unprognostic (1.71e-2)" "unprognostic (3.57e-2)" "unprognostic (7.03e-2)" 0.8 1.4 1.1 0.3 1.1 0.6 1.2 0.9 2.5 1.7 1.3 1.3 1.7 1.1 0.1 1.1 3.2 0.6 0.5 1.4 1.6 3.7 4.0 1.1 0.3 1.9 2.8 1.1 2.8 0.9 7.1 0.2 1.5 1.8 0.1 0.6 1.1 1.2 0.3 0.6 1.1 0.1 1.8 0.7 1.4 66.0 1.6 0.4 3.4 0.0 0.1 1.0 1.2 0.9 0.6 0.3 1.2 6.7 0.1 0.2 1.8 0.5 0.1 0.0 0.2 0.6 1.0 0.0 0.7 0.0 0.0 0.7 0.0 0.0 0.0 0.4 0.1 0.3 1.1 1.0 0.4 0.0 3.7 0.6 0.0 0.0 0.1 0.3 0.2 5.3 1.2 1.8 0.0 0.0 0.1 0.3 0.1 0.3 0.4 1.2 0.1 0.1 0.4 0.0 0.0 1.4 0.1 0.3 0.1 0.4 2.5 0.4 0.0 0.5 0.0 0.1 0.0 7.7 1.5 0.3 0.3 0.7 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.1 1.1 0.9 2.5 1.4 1.6 1.9 2.8 1.5 1.8 1.6 0.9 0.2 0.0 1.1 12.1 0.1 0.6 0.9 1.8 0.6 1.5 3.1 2.2 2.3 1.5 3.6 0.0 8.4 0.5 1.7 1.6 5.9 1.8 277.1 5.2 1.0 0.5 0.0 1.7 3.2 1.0 0.5 0.8 3.1 1.1 0.0 3.3 0.0 3.2 0.8 3.3 3.7 1.4 0.0 0.3 0.0 679.2 6.2 1.1 3.6 3.7 0.0 2.4 0.0 1.0 1.6 0.9 1.1 5.3 1.4 0.5 2.8 1.9 8.3 9.1 0.0 0.2 0.5 98.0 9.6 1.2 0.0 0.3 0.7 2.4 2.1 0.7 PCSK5 "PC5, PC6, SPC6" ENSG00000099139 "Proprotein convertase subtilisin/kexin type 5" Q92824 9 75890644-76362975 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" Pregnancy "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 189.7;Inhibitory neurons: 81.9;NK-cells: 82.4;Oligodendrocyte precursor cells: 149.3;Proximal enterocytes: 99.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 8 "basophil: 2447.1;neutrophil: 626.3" "Lineage enriched" "Detected in all" 18 "granulocytes: 2447.1" "Cell line enhanced" "Detected in many" "BEWO: 32.6;HaCaT: 46.9;RH-30: 30.4;RPTEC TERT1: 42.5;U-2 OS: 66.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA031072 Approved Supported "Golgi apparatus" "Secreted to blood" NA NA 290000 "Cluster 41: Basophils - Cellular respiration" "Cluster 45: Intestine - Brush border" "Cluster 9: U-2 OS - Unknown function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Golgi apparatus" "HPA031072: AB_10602190" "unprognostic (3.28e-2)" "unprognostic (1.44e-1)" "unprognostic (4.13e-4)" "unprognostic (4.08e-2)" "unprognostic (7.43e-3)" "unprognostic (3.17e-1)" "unprognostic (2.07e-3)" "unprognostic (9.39e-2)" "unprognostic (1.15e-1)" "unprognostic (5.92e-2)" "unprognostic (2.81e-2)" "unprognostic (6.80e-2)" "prognostic unfavorable (9.61e-5)" "unprognostic (2.99e-1)" "unprognostic (3.21e-2)" "unprognostic (3.22e-2)" "unprognostic (1.77e-5)" 17.6 4.2 6.6 5.9 6.6 2.3 6.9 22.2 23.8 9.0 0.0 10.2 25.0 7.1 9.6 8.5 6.9 8.6 5.3 7.4 7.8 3.8 1.7 6.1 2.7 21.7 17.3 13.5 3.0 5.9 2.3 9.4 20.0 3.3 8.4 6.0 3.5 3.0 3.0 3.6 26.4 6.6 23.0 3.3 3.3 6.3 5.3 9.1 4.8 5.4 2.5 5.3 8.8 2.4 2.5 1.8 5.1 3.4 3.2 1.0 32.6 4.7 0.4 0.3 0.0 18.7 2.0 0.8 1.3 0.6 0.1 46.9 2.4 1.4 0.3 0.6 4.1 6.3 4.5 1.6 0.8 1.9 2.8 6.0 0.4 1.0 0.5 0.3 9.6 3.1 7.5 2.4 3.3 11.5 7.4 11.1 22.8 4.3 1.9 1.3 30.4 1.9 42.5 2.9 0.7 0.5 7.1 1.5 0.5 9.5 2.6 8.0 7.6 1.5 66.5 3.8 2.0 0.7 0.3 1.0 5.1 2.7 25.7 2447.1 43.1 192.4 100.0 25.9 85.2 92.3 100.8 93.7 21.8 116.5 98.2 125.2 626.3 135.5 51.6 135.0 96.9 10.1 6.6 6.6 22.2 23.8 7.4 7.8 21.7 17.3 20.0 23.0 5.3 2.4 41.1 6.4 7.2 189.7 0.1 6.5 3.5 8.6 13.6 4.8 0.7 2.0 5.8 11.5 14.3 5.5 0.0 2.1 9.6 47.3 0.0 8.2 19.0 6.0 35.1 19.5 1.2 0.0 33.5 6.1 34.3 26.6 9.7 10.6 0.0 32.1 15.0 0.9 2.9 55.5 81.9 10.2 6.1 4.1 3.9 39.4 20.5 7.5 1.8 70.3 11.4 30.3 82.4 149.3 5.8 10.1 18.5 25.2 0.4 2.9 99.2 4.2 23.4 1.4 19.7 9.1 11.4 1.0 1.9 6.2 3.0 2.5 6.2 5.6 23.9 0.9 PCSK6 "PACE4, SPC4" ENSG00000140479 "Proprotein convertase subtilisin/kexin type 6" P29122 15 101289784-101525202 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 153.6;liver: 160.0;lymphoid tissue: 81.4" "Cell type enhanced" "Detected in many" "Hepatocytes: 231.6;Horizontal cells: 196.9;Oligodendrocytes: 561.9;Theca cells: 106.5" "Cancer enhanced" "Detected in many" "liver cancer: 8.1" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "NK-cell: 3.3" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "BEWO: 47.2;CACO-2: 35.7;HEK 293: 60.3;Hep G2: 53.8;OE19: 65.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004774 Uncertain "Secreted to extracellular matrix" NA NA 480000 "Cluster 15: NK-cells - Transcription" "Cluster 15: Liver - Metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA004774: AB_1079583" "prognostic favorable (9.99e-4)" "unprognostic (1.09e-1)" "unprognostic (4.37e-2)" "unprognostic (2.46e-2)" "unprognostic (9.83e-2)" "unprognostic (8.14e-2)" "unprognostic (2.20e-3)" "unprognostic (8.56e-2)" "unprognostic (2.16e-1)" "unprognostic (2.39e-2)" "unprognostic (3.85e-3)" "unprognostic (2.01e-1)" "prognostic unfavorable (7.06e-7)" "unprognostic (2.02e-1)" "unprognostic (1.87e-1)" "unprognostic (1.15e-1)" "unprognostic (1.03e-2)" 5.3 2.2 17.5 3.0 67.3 1.1 11.2 57.8 37.0 2.2 4.2 16.5 6.8 2.0 3.3 9.0 2.8 3.1 20.0 19.3 34.1 3.2 160.0 3.6 2.5 113.0 64.5 6.1 2.6 0.6 5.1 32.0 95.6 3.1 14.8 7.6 2.8 0.6 11.4 10.1 10.1 3.6 42.9 81.4 9.8 13.0 54.0 20.9 2.2 16.3 1.8 3.7 2.6 153.6 19.7 14.6 2.6 0.9 0.2 0.4 47.2 0.7 2.5 0.0 0.1 35.7 8.3 0.4 2.4 0.6 1.1 11.4 12.5 1.5 0.0 2.8 60.3 33.5 8.4 53.8 1.6 4.5 0.4 0.3 7.5 0.2 0.2 0.2 0.1 4.3 24.5 0.2 0.0 8.8 0.1 4.7 9.3 65.9 6.5 0.2 0.4 4.4 4.4 25.4 7.3 8.6 26.2 1.5 9.1 6.6 2.2 21.9 0.2 0.3 1.2 0.3 0.2 0.5 0.6 0.7 0.2 0.6 7.3 0.8 0.2 0.9 0.2 0.4 0.3 0.5 0.4 0.2 0.1 1.0 0.6 0.5 0.4 3.3 1.3 0.4 0.1 1.2 17.5 67.3 57.8 37.0 19.3 34.1 113.0 64.5 95.6 42.9 54.0 153.6 1.7 3.2 0.6 2.9 1.3 0.4 0.3 0.9 0.6 1.7 15.4 6.6 2.0 8.6 1.4 1.8 20.9 6.7 0.6 22.6 0.0 0.6 1.6 4.7 21.6 4.9 0.0 3.2 19.4 0.8 24.3 15.5 1.5 6.9 0.0 4.2 12.5 231.6 1.4 196.9 30.8 3.7 0.0 5.2 1.1 2.4 10.5 1.7 0.0 5.6 1.0 1.7 3.1 25.6 561.9 7.3 8.2 0.0 0.0 1.7 2.3 0.1 1.2 1.6 0.0 2.0 1.0 4.7 2.4 0.9 0.1 3.3 1.0 106.5 8.5 0.2 PCSK7 "LPC, PC7, PC8, SPC7" ENSG00000160613 "Proprotein convertase subtilisin/kexin type 7" Q16549 11 117204337-117232525 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "NK-cells: 310.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA 8400 "Cluster 15: NK-cells - Transcription" "Cluster 14: B-cells - Humoral immune response" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 63: NK-cells & T-cells - Immune response" "unprognostic (7.11e-2)" "unprognostic (2.90e-2)" "unprognostic (8.33e-3)" "unprognostic (4.24e-2)" "unprognostic (1.32e-1)" "unprognostic (2.77e-2)" "unprognostic (1.56e-1)" "unprognostic (2.60e-1)" "unprognostic (1.96e-1)" "unprognostic (2.41e-1)" "unprognostic (8.80e-2)" "unprognostic (1.09e-1)" "unprognostic (1.02e-1)" "unprognostic (1.51e-1)" "unprognostic (1.06e-1)" "unprognostic (1.00e-1)" "unprognostic (3.03e-2)" 31.8 16.4 16.4 27.9 17.6 25.7 24.0 15.9 20.9 27.5 16.7 69.5 29.2 72.4 7.6 24.0 35.7 12.9 20.1 19.9 16.6 15.7 19.6 25.6 31.6 18.1 17.0 17.5 29.7 11.8 16.6 13.5 18.0 35.4 37.5 10.0 15.9 11.2 15.6 20.7 35.4 13.5 15.7 30.7 45.1 12.5 18.3 25.0 18.1 10.7 29.2 39.4 22.2 20.2 14.6 27.5 19.1 21.4 23.3 19.0 15.0 48.5 22.2 24.1 23.9 38.3 82.6 24.8 33.5 38.6 31.1 48.0 25.2 34.7 15.5 34.2 24.2 36.7 40.7 17.5 26.1 23.2 49.4 32.9 22.5 33.0 26.4 12.4 41.2 28.0 22.5 22.0 34.8 19.0 31.5 24.3 17.6 63.4 28.1 19.1 16.9 29.5 30.1 33.7 24.9 32.3 39.6 51.1 7.5 14.8 32.3 18.6 36.4 36.4 16.4 31.5 34.3 13.4 8.7 14.0 18.6 33.1 33.3 7.9 7.1 9.0 38.1 9.8 33.0 23.5 29.7 35.6 7.6 18.5 20.8 24.7 5.3 41.0 11.5 8.8 42.8 20.6 16.4 17.6 15.9 20.9 19.9 16.6 18.1 17.0 18.0 15.7 18.3 20.2 47.4 48.1 36.2 44.4 93.3 70.1 50.0 35.2 19.4 124.1 31.2 23.5 8.1 35.8 42.5 47.8 246.0 50.7 97.4 204.9 5.9 27.4 6.4 21.0 40.3 47.5 62.4 27.4 47.2 54.5 39.0 38.5 110.6 36.5 34.1 30.2 77.4 27.8 32.4 87.5 41.4 91.2 24.4 60.6 83.9 7.5 33.5 39.2 53.4 25.3 54.6 21.8 310.0 48.2 62.0 73.7 132.2 39.9 58.7 39.0 98.2 9.2 22.9 178.8 72.3 87.5 107.7 64.4 24.5 27.4 94.3 62.5 127.3 42.7 110.3 53.3 PCSK9 "FH3, HCHOLA3, NARC-1" ENSG00000169174 "Proprotein convertase subtilisin/kexin type 9" Q8NBP7 1 55039447-55064852 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Apoptosis, Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Hydrolase, Protease, Serine protease" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "liver: 48.7" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 16.0;Alveolar cells type 2: 22.4;Gastric mucus-secreting cells: 8.2;Hepatocytes: 32.9" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in some" 7 "cerebellum: 3.4;medulla oblongata: 2.1;pons: 2.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 82.5;CACO-2: 37.0;HaCaT: 108.8;HeLa: 90.7;RPTEC TERT1: 56.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in single" "Secreted to blood" NA NA 143000000 420000000 "Cluster 85: Liver - Metabolism" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 15: Hepatocytes - Hemostasis" "unprognostic (1.28e-3)" "unprognostic (6.93e-2)" "unprognostic (4.02e-1)" "unprognostic (2.19e-2)" "unprognostic (7.30e-2)" "unprognostic (1.82e-1)" "unprognostic (1.20e-3)" "unprognostic (1.14e-2)" "unprognostic (5.44e-3)" "unprognostic (1.22e-2)" "unprognostic (2.09e-3)" "unprognostic (3.70e-2)" "unprognostic (2.45e-4)" "unprognostic (1.49e-1)" "unprognostic (1.86e-1)" "unprognostic (2.13e-1)" "prognostic unfavorable (2.40e-4)" 0.3 0.2 0.0 0.7 0.1 0.4 0.1 3.4 0.3 1.0 0.0 4.5 3.1 0.3 0.3 5.5 0.4 0.1 0.0 0.1 0.1 0.1 48.7 7.9 0.0 2.1 0.3 0.1 5.4 0.2 0.1 0.0 2.0 0.0 1.6 0.0 0.5 0.2 0.0 1.4 3.4 0.7 0.0 0.3 1.3 0.4 0.1 0.0 0.0 0.0 0.3 0.4 1.5 0.2 82.5 17.6 2.8 0.0 6.4 4.4 0.2 0.0 0.0 0.2 0.2 37.0 13.2 0.0 13.9 7.8 0.3 108.8 3.5 35.2 0.0 0.0 0.0 0.0 90.7 26.5 2.2 0.0 0.0 6.4 25.5 25.2 18.4 0.0 0.0 0.0 10.6 0.0 0.0 0.0 0.0 0.0 15.1 1.5 1.9 0.0 0.0 0.9 56.4 0.1 1.3 0.0 10.5 0.0 0.3 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 3.4 0.3 0.1 0.1 2.1 0.3 2.0 0.0 0.1 0.2 0.0 16.0 22.4 0.0 0.2 0.5 0.0 2.1 1.2 0.0 0.0 0.0 0.6 0.0 1.8 0.0 0.0 0.0 0.0 2.0 0.0 0.5 0.2 0.8 0.1 0.1 4.2 2.7 0.1 1.5 0.0 0.6 8.2 0.8 0.0 0.1 1.1 32.9 0.1 0.0 0.1 4.3 2.0 1.6 0.5 0.6 0.0 0.2 1.8 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.6 0.0 0.0 0.1 0.3 0.0 0.6 0.0 0.0 0.0 0.1 0.6 1.3 1.4 0.6 0.0 0.1 0.0 5.4 0.4 PEPD ENSG00000124299 "Peptidase D" P12955 19 33386950-33521791 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Collagen degradation" "Dipeptidase, Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 209.5;kidney: 277.7" "Group enriched" "Detected in all" 4 "Proximal enterocytes: 833.0;Proximal tubular cells: 1278.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015599, HPA072045" Enhanced Approved Nucleoplasm NA NA 860000000 "Cluster 39: Non-specific - mRNA processing" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "HPA015599: AB_1855192, HPA072045: AB_2732194" "unprognostic (1.39e-1)" "unprognostic (2.62e-2)" "unprognostic (2.27e-1)" "unprognostic (4.01e-2)" "unprognostic (2.98e-1)" "unprognostic (6.77e-2)" "unprognostic (2.82e-1)" "unprognostic (3.64e-2)" "unprognostic (3.96e-1)" "unprognostic (5.10e-2)" "unprognostic (1.11e-2)" "unprognostic (1.99e-1)" "prognostic favorable (6.50e-9)" "unprognostic (4.38e-2)" "unprognostic (1.99e-1)" "unprognostic (1.65e-1)" "unprognostic (1.29e-1)" 53.2 56.0 28.5 26.9 35.5 14.3 43.6 35.6 30.5 36.9 33.5 44.2 180.5 49.7 9.9 42.8 34.2 31.2 24.3 28.7 30.9 277.7 117.8 38.1 30.7 36.2 30.8 35.9 27.1 29.3 42.5 21.9 36.3 23.6 14.8 11.8 33.6 22.9 35.6 43.1 209.5 24.5 34.6 38.2 33.6 18.3 33.4 20.8 37.0 23.2 21.3 40.1 28.2 43.4 43.2 118.7 26.4 53.1 114.9 44.9 80.6 37.4 65.3 45.6 52.7 104.7 34.2 18.8 53.5 73.2 33.9 11.2 39.5 28.5 23.4 51.3 50.4 107.7 24.6 108.3 91.6 29.6 128.8 63.6 29.0 38.2 18.3 27.8 56.4 34.4 22.7 49.4 44.2 54.3 19.0 11.7 46.2 79.6 48.8 45.3 41.0 51.2 39.4 108.8 40.3 106.4 64.2 31.3 62.5 18.2 25.1 36.3 56.6 48.3 46.6 62.3 41.8 45.2 59.1 13.1 49.5 48.2 65.8 113.7 117.2 8.3 75.5 123.6 65.5 49.6 74.0 69.8 100.6 50.5 47.1 55.6 6.1 55.6 92.5 31.0 76.1 119.6 28.5 35.5 35.6 30.5 28.7 30.9 36.2 30.8 36.3 34.6 33.4 43.4 56.9 22.4 27.4 11.4 29.0 19.4 32.9 36.0 11.4 33.3 16.2 24.4 13.3 52.9 23.8 73.5 4.2 21.4 32.6 17.6 197.6 77.2 8.0 15.0 20.1 50.7 17.3 25.4 19.9 44.2 67.3 38.6 18.3 13.0 57.6 41.9 52.8 180.3 227.2 62.2 14.9 35.6 30.5 59.7 40.9 13.2 49.4 75.3 67.6 15.9 102.2 73.6 34.0 21.6 24.3 33.8 79.3 60.5 31.5 22.9 833.0 1278.3 27.1 33.7 39.5 37.0 43.1 10.2 44.5 34.3 20.3 30.4 33.7 48.7 44.6 22.2 PGA3 ENSG00000229859 "Pepsinogen A3" P0DJD8 11 61203307-61213098 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" Digestion "Aspartyl protease, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 613 "stomach 1: 89073.4" "Cell type enriched" "Detected in some" 526 "Gastric mucus-secreting cells: 3263.5" "Cancer enriched" "Detected in single" 498 "stomach cancer: 24.8" "Region enhanced" "Detected in single" "hippocampal formation: 2.9" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "HMC-1: 2.8;THP-1: 1.1" "CAB026358, HPA046875" Enhanced "Secreted to digestive system" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 4: Stomach - Digestion" "Cluster 3: HMC-1 - Innate immune response" "Cluster 16: Pancreatic endocrine cells - Mixed function" "CAB026358: , HPA046875: AB_2679851" "unprognostic (6.39e-2)" "unprognostic (1.11e-1)" 80.5 10.0 0.5 0.2 0.2 0.2 18.2 0.7 0.9 11.1 0.0 145.3 1.3 3.8 0.0 96.4 4.5 0.1 11.4 2.9 0.0 5.4 16.2 6.2 0.0 0.0 0.0 5.4 13.0 0.0 13.4 0.5 0.1 5.5 0.1 0.9 6.8 0.7 4.4 6.0 5.7 0.4 0.0 6.3 89073.4 7.3 0.0 0.1 5.0 0.5 0.1 6.2 6.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.8 0.1 0.7 1.3 0.4 0.1 0.2 0.7 0.1 0.1 0.1 0.6 0.4 0.2 0.3 0.0 0.0 1.3 0.5 0.2 0.7 0.9 2.9 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.9 0.0 0.2 0.0 0.0 0.5 0.1 0.0 0.9 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.1 0.0 0.0 0.0 6.2 0.0 0.3 3263.5 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.8 0.5 0.0 0.0 0.7 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.2 0.0 0.0 1.1 0.1 0.0 0.1 0.0 3.1 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.4 0.2 0.0 0.1 PGA4 ENSG00000229183 "Pepsinogen A4" P0DJD7 11 61222349-61231694 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" Digestion "Aspartyl protease, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 1281 "stomach 1: 66596.4" "Cell type enriched" "Detected in some" 8 "Exocrine glandular cells: 109.1" "Not detected" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 19 "classical monocyte: 9.9;intermediate monocyte: 10.9;non-classical monocyte: 3.4" "Lineage enriched" "Detected in single" 26 "monocytes: 10.9" "Group enriched" "Detected in some" 6 "BJ hTERT+: 26.1;HMC-1: 9.5;THP-1: 15.7" HPA046875 Supported "Secreted to digestive system" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 4: Stomach - Digestion" "Cluster 3: HMC-1 - Innate immune response" "Cluster 1: Pancreatic cells - Digestion" "HPA046875: AB_2679851" "unprognostic (2.22e-1)" 9.6 8.3 0.1 2.1 0.1 0.0 9.0 0.1 0.2 7.5 0.1 52.0 2.5 4.6 0.0 9.1 19.1 0.3 6.2 0.1 0.1 30.3 11.7 37.9 0.0 0.1 0.1 4.1 18.8 0.0 3.5 3.8 0.1 16.2 0.4 0.3 4.5 0.7 2.5 4.1 2.9 0.8 0.1 5.2 66596.4 4.3 0.1 0.1 3.1 0.0 0.2 5.0 5.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 26.1 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 9.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 2.0 0.0 1.6 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.7 0.0 0.0 1.1 0.1 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 9.9 0.0 0.0 10.9 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.3 0.0 3.4 0.0 0.0 1.8 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.0 109.1 0.0 0.0 13.3 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PGA5 ENSG00000256713 "Pepsinogen A5" P0DJD9 11 61241175-61251444 "Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins" Digestion "Aspartyl protease, Hydrolase, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 2014 "stomach 1: 39870.8" "Cell type enriched" "Detected in some" 77 "Exocrine glandular cells: 4383.1" "Cancer enriched" "Detected in some" 12 "stomach cancer: 15.0" "Not detected" "Not detected" "Group enriched" "Detected in some" 29 "classical monocyte: 1.8;intermediate monocyte: 4.3;non-classical monocyte: 2.4" "Lineage enriched" "Detected in single" 44 "monocytes: 4.3" "Cell line enriched" "Detected in some" 19 "BJ hTERT+: 28.8" HPA046875 Supported "Secreted to digestive system" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 4: Stomach - Digestion" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 1: Pancreatic cells - Digestion" "HPA046875: AB_2679851" "unprognostic (1.36e-3)" "unprognostic (2.98e-2)" "unprognostic (5.83e-3)" "unprognostic (2.11e-1)" "unprognostic (4.22e-1)" "unprognostic (4.36e-2)" "unprognostic (2.16e-2)" "unprognostic (1.05e-1)" "unprognostic (7.10e-2)" 19.7 4.4 0.3 1.1 0.3 0.0 4.5 0.1 0.6 4.0 0.0 6.2 0.6 1.9 0.0 7.0 5.1 0.1 3.5 0.7 0.0 2.4 7.0 5.4 0.0 0.1 0.0 2.6 8.2 0.0 3.8 0.5 0.1 1.8 0.1 1.5 2.5 0.5 1.9 2.1 2.1 0.9 0.0 3.9 39870.8 2.3 0.0 0.2 3.1 0.2 0.1 2.3 2.5 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 28.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 1.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 4.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.3 0.3 0.3 0.1 0.6 0.7 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.5 0.0 0.0 0.0 0.0 0.0 0.1 4383.1 0.0 0.1 56.6 0.0 0.0 0.2 0.0 0.0 6.7 0.0 0.0 0.0 0.0 5.1 0.0 1.6 0.9 1.3 0.0 0.0 1.0 25.1 0.0 0.0 0.0 8.2 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 PGC ENSG00000096088 Progastricsin P20142 6 41736711-41754109 "Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted secreted proteins, Transporters" Digestion "Aspartyl protease, Hydrolase, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 45 "stomach 1: 59821.1" "Group enriched" "Detected in some" 10 "Gastric mucus-secreting cells: 5737.5;Pancreatic endocrine cells: 1449.1" "Cancer enhanced" "Detected in many" "stomach cancer: 1050.3" "Region enhanced" "Detected in single" "cerebellum: 1.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 11 "Hep G2: 253.1;OE19: 152.2" "Not detected" "Not detected" "Not detected" "Not detected" "HPA031717, HPA031718" Enhanced Approved Nucleoplasm "Secreted to digestive system" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 4: Stomach - Digestion" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 16: Pancreatic endocrine cells - Mixed function" Nucleoplasm "HPA031717: AB_10670130, HPA031718: AB_10610148" "unprognostic (9.18e-2)" "unprognostic (1.87e-1)" "unprognostic (9.83e-2)" "unprognostic (2.27e-1)" "unprognostic (7.18e-2)" "unprognostic (2.74e-1)" "unprognostic (1.47e-1)" "unprognostic (8.50e-2)" "unprognostic (1.86e-1)" "unprognostic (9.23e-2)" "unprognostic (1.09e-1)" "unprognostic (1.33e-2)" "unprognostic (2.92e-1)" "unprognostic (1.65e-1)" "unprognostic (8.74e-2)" 19.4 7.0 0.0 0.3 0.1 0.2 6.6 1.2 0.5 6.7 0.0 26.4 1327.3 2.8 0.9 85.5 9.2 2.3 6.2 0.1 0.0 4.9 11.0 378.8 0.3 0.0 0.0 3.9 136.3 0.0 7.4 2.8 0.0 83.9 0.3 0.1 4.6 437.7 2.5 3.4 3.2 0.0 0.0 7.7 59821.1 4.2 0.0 0.1 2.2 0.0 0.3 3.8 4.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 15.5 0.0 0.1 0.0 0.0 18.4 0.0 0.0 0.6 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 253.1 0.0 0.3 6.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 4.5 0.9 5.7 152.2 0.0 2.9 0.0 6.2 0.0 0.2 0.0 0.7 0.0 0.0 0.0 0.3 0.0 2.8 0.0 0.0 3.7 0.1 0.0 4.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.2 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 25.6 335.2 0.0 4.4 0.4 2.8 0.0 0.0 0.0 0.3 0.8 0.3 87.2 5.0 0.0 0.0 1.2 0.0 0.3 0.0 4.6 0.0 0.4 0.0 1.1 0.0 0.0 0.3 131.2 1.5 0.9 5737.5 0.1 10.1 0.0 0.0 0.2 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.3 1.7 0.0 0.0 2.0 0.0 0.0 0.0 0.1 1449.1 2.1 0.0 2.4 85.2 0.1 0.2 3.0 0.0 0.0 0.0 0.6 0.0 0.5 0.0 0.0 4.1 2.6 0.0 0.2 4.2 PGPEP1 "Pcp, PGP, PGP-I, PGPI" ENSG00000130517 "Pyroglutamyl-peptidase I" Q9NXJ5 19 18340598-18369950 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 73.9;Proximal enterocytes: 88.2;Proximal tubular cells: 85.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 28.4" "Lineage enriched" "Detected in all" 4 "granulocytes: 28.4" "Cell line enhanced" "Detected in many" "HMC-1: 58.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035368, HPA055277" Approved Approved "Golgi apparatus" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Golgi apparatus" "HPA035368: AB_10601388, HPA055277: AB_2682770" "unprognostic (9.52e-3)" "unprognostic (1.37e-2)" "unprognostic (6.95e-2)" "unprognostic (5.74e-3)" "unprognostic (5.29e-2)" "unprognostic (6.60e-2)" "unprognostic (1.96e-2)" "unprognostic (2.11e-3)" "prognostic favorable (6.80e-4)" "unprognostic (2.79e-2)" "prognostic favorable (1.71e-4)" "unprognostic (4.81e-3)" "prognostic favorable (3.71e-8)" "unprognostic (1.12e-2)" "unprognostic (1.66e-1)" "unprognostic (1.51e-1)" "unprognostic (1.20e-3)" 10.1 27.8 30.1 6.9 30.2 13.1 10.3 27.0 36.7 14.9 38.3 23.5 22.4 11.1 12.8 5.5 12.7 7.9 25.1 31.0 30.6 40.8 48.4 14.3 6.5 35.6 28.9 16.5 34.2 13.9 24.4 5.2 36.2 20.3 15.6 4.2 20.4 12.9 27.1 4.9 30.3 6.4 36.2 23.5 23.6 3.8 30.2 8.2 14.6 14.4 6.3 15.9 8.3 35.5 8.7 13.6 11.1 11.2 13.7 10.8 13.5 10.2 15.9 6.9 10.2 9.7 18.4 13.4 16.7 16.8 12.3 2.3 4.4 2.3 3.8 15.9 4.8 14.7 15.0 27.9 19.4 8.7 58.5 10.9 4.9 5.3 1.0 24.6 10.4 22.8 27.5 19.7 5.8 13.9 8.9 7.0 11.3 6.0 4.2 0.1 4.1 12.1 7.5 13.5 3.9 6.1 1.9 1.1 18.4 7.2 5.1 17.3 16.1 7.9 5.3 10.4 4.4 24.3 12.6 8.2 21.0 24.0 7.4 28.4 5.5 8.1 4.8 5.8 2.9 1.9 3.4 4.5 3.5 5.5 4.2 3.8 3.1 4.8 6.8 2.3 4.2 3.9 30.1 30.2 27.0 36.7 31.0 30.6 35.6 28.9 36.2 36.2 30.2 35.5 7.5 9.6 15.0 10.4 12.2 2.3 10.2 9.5 8.6 4.7 14.3 9.8 20.9 37.1 13.2 31.3 10.4 18.6 21.2 73.9 7.9 20.7 0.8 15.2 8.6 10.0 38.9 10.7 11.3 45.4 26.6 9.6 27.5 14.7 35.4 7.9 13.6 72.5 24.1 5.0 7.9 21.0 8.2 29.0 5.4 1.7 7.8 19.3 16.0 8.4 13.1 8.9 24.7 3.5 4.3 44.4 36.5 20.3 25.8 9.2 88.2 85.7 12.3 7.0 6.6 10.3 9.0 2.9 4.7 1.8 1.1 18.7 15.2 9.4 33.4 16.9 PGPEP1L ENSG00000183571 "Pyroglutamyl-peptidase I like" A6NFU8 15 98968229-99007792 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enriched" "Detected in some" 4 "skeletal muscle: 30.9" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 2.1;Distal tubular cells: 1.9;Early spermatids: 3.8;Excitatory neurons: 3.8;Inhibitory neurons: 3.3;Late spermatids: 1.7;Skeletal myocytes: 2.1;Spermatocytes: 2.7;Spermatogonia: 2.3" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in some" HPA041781 Uncertain NA NA "Cluster 46: Basophils - DNA binding" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 37: Myocytes - Muscle contraction" "HPA041781: AB_10795642" "unprognostic (2.48e-1)" "unprognostic (2.82e-2)" "unprognostic (8.26e-2)" "unprognostic (2.43e-3)" "unprognostic (7.18e-2)" "unprognostic (3.99e-2)" "unprognostic (1.69e-1)" "unprognostic (5.44e-2)" "unprognostic (9.78e-2)" "unprognostic (1.58e-1)" "unprognostic (4.53e-3)" "unprognostic (1.86e-1)" "unprognostic (2.62e-1)" "unprognostic (2.00e-2)" "unprognostic (1.65e-1)" 0.2 0.1 0.7 0.2 0.9 0.1 0.4 0.0 1.1 0.2 0.0 0.5 0.2 0.2 0.0 0.8 0.1 0.5 3.8 0.5 0.4 0.4 0.0 0.2 0.3 0.2 0.3 0.1 0.5 0.0 0.1 0.2 0.1 0.5 0.0 0.1 0.6 0.5 30.9 0.1 0.1 0.1 0.0 0.0 0.2 2.0 0.4 0.1 0.1 7.5 0.0 0.3 0.3 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.3 0.0 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.2 0.0 0.1 0.0 0.7 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.7 0.9 0.0 1.1 0.5 0.4 0.2 0.3 0.1 0.0 0.4 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.4 2.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.9 0.0 3.8 0.1 0.1 0.0 0.0 0.0 3.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.1 0.9 2.7 2.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 PHEX "HPDR, HPDR1, HYP, HYP1, PEX, XLH" ENSG00000102174 "Phosphate regulating endopeptidase homolog X-linked" P78562 X 22032325-22251310 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins" Biomineralization "Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "lung: 2.7" "Group enriched" "Detected in many" 5 "dendritic cells: 45.3;Granulosa cells: 161.7" "Cancer enriched" "Detected in some" 4 "thyroid cancer: 5.9" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 37 "plasmacytoid DC: 4.8" "Lineage enriched" "Detected in single" 37 "dendritic cells: 4.8" "Cell line enhanced" "Detected in some" "HBEC3-KT: 3.7;HUVEC TERT2: 2.8;PC-3: 3.0;TIME: 3.1;U-87 MG: 6.5;WM-115: 2.8" "Low region specificity" "Detected in some" "Low region specificity" "Detected in some" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 40: Granulosa cells - Unknown function" "unprognostic (2.01e-2)" "unprognostic (2.69e-1)" "unprognostic (2.43e-1)" "unprognostic (1.05e-3)" "unprognostic (1.22e-1)" "unprognostic (3.04e-2)" "unprognostic (2.25e-3)" "unprognostic (1.23e-1)" "unprognostic (1.87e-1)" "unprognostic (1.21e-2)" "unprognostic (7.53e-2)" "unprognostic (7.45e-2)" "unprognostic (9.84e-8)" "unprognostic (1.18e-1)" "unprognostic (1.58e-1)" "prognostic favorable (2.51e-4)" "unprognostic (7.68e-2)" 0.0 0.0 1.0 0.5 1.0 0.0 0.7 1.8 0.7 0.9 0.4 0.3 0.5 2.0 0.1 0.2 0.1 0.9 0.0 0.8 2.2 0.1 0.0 2.7 1.5 1.6 1.6 1.6 0.0 0.0 0.2 0.1 1.9 0.6 0.0 0.3 0.2 0.4 0.0 0.1 0.6 1.5 1.8 0.4 0.0 0.1 1.3 0.3 1.0 0.3 0.9 0.2 0.3 2.1 0.2 0.5 0.1 0.0 0.0 0.2 0.0 0.0 0.1 0.1 0.1 0.8 0.0 0.1 0.8 0.0 0.1 0.1 0.0 3.7 0.2 0.0 0.1 0.1 0.3 0.0 0.0 0.0 0.1 1.3 0.7 0.7 2.1 0.1 2.8 0.2 0.0 0.3 0.3 0.0 0.0 0.1 0.0 0.0 3.0 0.0 0.6 0.0 0.4 0.1 0.1 0.1 0.2 1.5 0.5 0.4 1.8 0.0 3.1 0.6 0.1 0.4 0.5 0.0 0.0 0.0 6.5 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 4.8 0.0 0.0 1.0 1.0 1.8 0.7 0.8 2.2 1.6 1.6 1.9 1.8 1.3 2.1 0.0 0.0 0.0 3.9 0.8 0.0 5.8 2.3 0.0 0.4 3.0 1.8 0.5 0.0 1.6 0.0 0.0 0.2 45.3 0.7 0.0 0.9 0.4 1.3 1.4 0.2 0.0 0.0 2.2 1.2 0.1 2.9 0.0 1.8 0.0 161.7 0.0 0.0 0.0 16.8 1.9 0.5 4.1 0.0 0.4 0.3 1.8 1.2 1.8 0.0 0.0 0.6 0.0 1.5 0.5 0.8 0.0 0.0 0.3 1.8 8.2 0.9 4.5 0.5 0.0 2.1 2.6 0.1 0.4 0.1 0.1 0.8 0.4 18.9 0.4 3.3 PIGK "GPI8, hGPI8" ENSG00000142892 "Phosphatidylinositol glycan anchor biosynthesis class K" Q92643 1 77088989-77219430 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "GPI-anchor biosynthesis" "Hydrolase, Protease, Thiol protease" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA056383, HPA057040" Uncertain "Intracellular and membrane" NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 1: Thyroid gland - Transcription" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "HPA056383: AB_2683109, HPA057040: AB_2683319" "unprognostic (2.43e-2)" "unprognostic (2.60e-1)" "unprognostic (4.07e-2)" "unprognostic (2.24e-2)" "unprognostic (3.65e-1)" "unprognostic (1.15e-1)" "prognostic unfavorable (4.68e-4)" "unprognostic (1.07e-1)" "unprognostic (5.19e-1)" "unprognostic (1.12e-1)" "unprognostic (4.17e-2)" "unprognostic (1.85e-2)" "unprognostic (1.76e-2)" "unprognostic (3.37e-1)" "unprognostic (1.38e-1)" "unprognostic (1.21e-1)" "unprognostic (8.12e-3)" 9.8 12.4 5.2 6.3 6.6 8.8 12.4 6.1 9.4 9.7 5.7 8.5 6.9 9.5 9.7 6.5 9.3 10.0 14.1 6.0 6.4 17.7 13.2 9.2 8.8 5.9 5.5 9.6 9.6 16.3 6.5 6.4 6.2 11.2 9.3 9.8 9.5 8.8 7.0 4.8 7.3 10.7 6.8 9.8 8.9 6.0 5.5 8.5 16.3 9.8 7.5 9.3 4.2 9.8 12.3 14.2 11.5 14.7 64.1 48.1 18.6 24.4 33.1 25.0 35.6 11.8 12.2 10.7 24.4 43.1 29.7 10.8 14.8 20.8 45.2 22.1 15.1 14.6 13.8 11.1 14.4 32.5 12.4 29.2 11.1 26.7 22.9 29.9 37.4 13.2 18.0 35.6 39.0 8.3 10.3 13.2 10.4 13.7 23.4 12.0 33.7 13.3 31.9 8.9 9.7 9.1 23.2 20.8 27.1 18.9 10.0 18.5 21.5 40.1 15.6 21.9 25.0 16.1 23.7 10.7 29.8 40.5 16.2 7.2 3.0 5.8 5.8 3.4 6.0 3.7 6.0 5.0 5.7 3.2 7.5 6.8 1.5 7.4 3.5 3.9 9.8 4.7 5.2 6.6 6.1 9.4 6.0 6.4 5.9 5.5 6.2 6.8 5.5 9.8 17.7 9.6 9.1 16.3 14.4 9.6 15.2 23.7 5.2 14.2 21.0 14.2 23.0 18.6 18.3 40.5 2.1 16.0 14.1 9.7 3.9 20.8 2.1 15.6 15.5 18.1 10.8 16.4 51.4 21.1 35.7 29.3 6.6 14.1 17.7 14.7 20.3 29.3 20.3 8.4 40.2 12.4 24.4 14.5 13.9 3.7 19.6 11.9 19.6 26.2 9.2 17.6 18.6 40.7 78.2 11.9 8.5 27.4 41.7 10.1 9.3 23.3 25.3 12.4 52.6 16.3 24.1 75.8 30.2 9.4 11.9 15.2 15.5 12.7 12.7 11.5 PITRM1 "hMP1, KIAA1104, MP1, PreP" ENSG00000107959 "Pitrilysin metallopeptidase 1" Q5JRX3 10 3137728-3172841 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 186.1;Late spermatids: 98.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006753, HPA006754" Enhanced Supported Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 59: Non-specific - Translation" "Cluster 18: U-2197 - ECM organization" "Cluster 34: Spermatids - Unknown function" Mitochondria "HPA006753: AB_1079624, HPA006754: AB_1079623" "unprognostic (1.83e-3)" "unprognostic (7.01e-3)" "unprognostic (2.19e-1)" "unprognostic (1.69e-1)" "unprognostic (3.20e-2)" "unprognostic (6.67e-2)" "unprognostic (1.55e-1)" "unprognostic (1.78e-1)" "unprognostic (6.31e-2)" "unprognostic (3.41e-1)" "unprognostic (1.00e-2)" "unprognostic (3.32e-1)" "unprognostic (7.10e-2)" "unprognostic (3.99e-1)" "unprognostic (5.80e-2)" "unprognostic (4.76e-3)" "unprognostic (2.08e-2)" 40.8 64.9 22.7 19.1 24.9 26.0 36.9 23.8 34.2 40.9 22.9 40.9 19.6 40.5 23.8 38.4 38.0 18.3 60.2 25.2 24.5 50.5 44.9 40.4 21.0 25.3 26.0 54.4 41.1 33.3 42.3 17.0 26.0 42.6 22.1 49.6 41.3 22.1 94.9 39.2 32.7 25.8 21.0 30.4 37.0 43.6 26.1 42.4 41.7 59.6 21.7 43.6 38.4 28.5 81.8 67.2 21.7 31.7 62.1 67.6 22.3 125.9 51.0 92.5 49.1 55.5 45.5 38.5 39.5 70.7 33.2 55.8 37.8 82.4 74.3 72.3 55.0 61.1 42.9 39.2 36.2 21.8 62.3 50.4 57.0 103.5 55.8 55.4 81.2 56.3 60.1 44.5 115.7 67.1 59.6 14.0 15.0 97.9 71.0 27.5 34.1 54.0 67.9 54.8 29.4 16.4 95.9 57.5 46.6 35.8 67.2 23.9 114.5 63.7 17.2 160.5 47.8 36.1 48.6 41.7 108.8 38.2 31.5 3.1 6.9 1.5 10.3 8.8 10.5 10.4 9.5 10.9 13.3 5.3 9.7 11.1 0.3 13.7 11.9 5.3 12.6 8.5 22.7 24.9 23.8 34.2 25.2 24.5 25.3 26.0 26.0 21.0 26.1 28.5 12.2 28.9 29.0 13.4 9.3 6.8 17.6 11.1 6.2 13.1 10.7 12.2 44.9 8.6 23.5 3.7 20.9 13.4 7.9 12.4 7.9 18.2 186.1 14.5 14.6 14.0 18.0 10.7 18.4 29.2 20.0 14.7 16.8 23.1 14.5 18.0 7.1 16.3 14.8 6.7 17.9 12.7 20.3 10.1 6.3 98.7 17.1 10.0 19.6 6.5 9.9 7.1 4.1 11.1 14.7 34.8 10.0 14.7 13.7 23.9 10.6 8.5 19.1 19.7 6.6 16.9 15.3 28.1 21.6 17.0 5.7 13.5 10.1 30.4 12.9 17.7 PLAT ENSG00000104368 "Plasminogen activator, tissue type" P00750 8 42174718-42207709 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Plasminogen activation" "Hydrolase, Protease, Serine protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "parathyroid gland: 246.0;urinary bladder: 181.4" "Group enriched" "Detected in many" 4 "Basal prostatic cells: 763.3;Urothelial cells: 992.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CAPAN-2: 604.7;HMC-1: 425.2;hTERT-RPE1: 344.9;LHCN-M2: 298.2;U-2197: 441.2;WM-115: 806.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003412, CAB009335" Supported Approved "Actin filaments" "Secreted to blood" NA NA 9900000 110000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 17: WM-115 - Nervous system development" "Cluster 22: Epithelial cell types - Mixed function" "Actin filaments" "CAB009335: AB_2237146, HPA003412: AB_1858205" "prognostic favorable (7.57e-4)" "unprognostic (2.23e-1)" "unprognostic (4.08e-1)" "unprognostic (3.39e-1)" "unprognostic (4.88e-3)" "unprognostic (9.39e-2)" "unprognostic (4.65e-3)" "unprognostic (5.78e-2)" "unprognostic (1.55e-1)" "unprognostic (1.75e-1)" "unprognostic (2.98e-3)" "unprognostic (2.46e-1)" "prognostic unfavorable (4.95e-4)" "unprognostic (8.72e-3)" "unprognostic (1.37e-2)" "unprognostic (2.63e-2)" "unprognostic (6.09e-2)" 58.9 44.0 14.0 35.6 13.7 0.1 35.1 14.6 17.4 21.8 10.3 55.3 29.9 49.6 16.8 33.7 49.8 40.4 19.3 12.5 16.6 91.9 5.3 41.3 2.3 15.4 15.4 21.5 16.0 246.0 13.3 44.4 16.6 54.0 25.0 2.1 15.6 29.1 8.8 6.2 34.6 32.9 16.0 2.0 41.8 11.9 18.8 4.4 30.9 9.8 2.7 181.4 33.1 14.0 4.2 1.4 29.0 9.1 43.1 61.9 0.9 125.8 216.4 54.2 43.4 1.4 604.7 0.0 4.4 17.1 28.4 14.5 0.3 23.9 78.5 64.6 8.4 0.7 1.0 0.6 253.9 0.2 425.2 65.6 0.4 140.3 6.0 344.9 103.9 0.2 4.6 0.8 298.2 0.0 0.6 0.5 42.3 0.3 48.2 0.2 103.5 0.3 12.6 0.4 0.3 7.4 0.2 0.4 158.7 39.7 1.0 0.3 189.3 11.6 43.1 441.2 15.6 0.2 1.1 0.2 9.7 0.2 806.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 14.0 13.7 14.6 17.4 12.5 16.6 15.4 15.4 16.6 16.0 18.8 14.0 63.5 0.0 13.7 0.0 2.9 10.8 763.3 155.9 7.4 4.7 103.9 66.3 7.4 1.5 19.1 0.0 4.2 0.6 0.9 0.1 0.0 9.3 0.9 4.8 104.2 98.2 0.0 0.0 1.6 0.6 1.3 136.5 2.0 5.1 164.0 89.7 36.4 0.8 1.9 1.7 4.0 0.0 4.1 1.0 17.7 1.5 3.7 4.7 23.2 25.3 1.6 2.1 1.0 42.7 0.3 52.0 0.0 2.6 2.8 193.3 0.2 0.3 4.0 3.8 13.1 10.8 48.3 1.1 0.6 13.6 13.5 0.7 6.0 0.5 0.5 992.1 PLAU "UPA, URK" ENSG00000122861 "Plasminogen activator, urokinase" P00749 10 73909177-73917496 "Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Blood coagulation, Fibrinolysis, Hemostasis, Plasminogen activation" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 103.8;urinary bladder: 128.5" "Group enriched" "Detected in many" 4 "Basal prostatic cells: 635.9;Basal respiratory cells: 237.3;Pancreatic endocrine cells: 613.9;Prostatic glandular cells: 695.0;Urothelial cells: 869.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 9 "myeloid DC: 1.1;neutrophil: 2.1;plasmacytoid DC: 2.0" "Group enriched" "Detected in many" 11 "dendritic cells: 2.0;granulocytes: 2.1" "Cell line enhanced" "Detected in many" "CAPAN-2: 856.0;LHCN-M2: 822.4;RPTEC TERT1: 3100.7;U-251 MG: 869.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA070796 Supported Uncertain "Golgi apparatus,Vesicles" "Secreted to blood" NA NA 647000 88000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 82: Adipose tissue - ECM organization" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 22: Epithelial cell types - Mixed function" "Golgi apparatus, Vesicles" "HPA070796: " "unprognostic (1.96e-2)" "unprognostic (2.99e-2)" "unprognostic (7.40e-2)" "prognostic favorable (3.38e-4)" "unprognostic (4.73e-2)" "prognostic unfavorable (2.70e-4)" "unprognostic (1.39e-2)" "prognostic unfavorable (4.04e-4)" "unprognostic (2.26e-1)" "unprognostic (6.58e-2)" "prognostic unfavorable (1.32e-4)" "unprognostic (1.61e-1)" "prognostic unfavorable (3.51e-4)" "unprognostic (2.83e-1)" "unprognostic (3.37e-2)" "unprognostic (1.51e-2)" "unprognostic (1.77e-2)" 57.6 4.8 2.5 41.7 2.7 36.2 17.6 2.7 8.9 9.3 4.4 13.1 11.9 22.0 16.7 14.4 10.3 28.5 23.1 2.4 2.9 103.8 5.0 22.0 14.3 3.8 2.9 2.3 10.1 8.3 2.9 36.5 5.4 9.1 18.2 0.3 17.3 13.7 10.8 25.5 13.7 23.4 3.3 40.6 15.7 3.7 4.7 5.9 17.9 18.9 7.2 128.5 16.2 4.7 171.1 88.9 36.8 1.7 3.1 59.5 2.0 101.9 461.6 40.0 62.2 2.3 856.0 0.1 184.0 14.5 416.9 114.1 0.9 165.8 44.8 9.9 0.0 0.1 4.4 1.7 72.6 15.6 32.3 158.7 20.2 271.4 103.7 447.0 114.7 1.0 1.1 0.9 822.4 0.2 0.2 22.7 10.8 0.3 244.5 0.4 112.6 0.9 3100.7 130.6 0.1 0.2 0.3 4.0 2.4 25.4 1.2 22.9 300.6 3.5 20.3 21.6 869.8 0.2 1.3 1.6 216.0 25.5 1.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 2.1 0.0 0.0 2.0 0.0 0.1 2.5 2.7 2.7 8.9 2.4 2.9 3.8 2.9 5.4 3.3 4.7 4.7 29.0 3.2 4.6 0.3 1.4 37.3 635.9 237.3 19.9 0.0 3.0 24.4 2.5 0.0 103.6 29.5 0.0 28.0 1.6 0.6 68.4 62.7 0.5 50.7 22.2 46.4 3.5 0.0 0.2 21.3 21.7 69.7 0.0 68.9 31.1 0.1 3.9 0.0 39.8 0.0 0.3 0.1 140.4 4.0 33.1 1.3 2.5 53.4 7.2 4.7 23.8 0.0 0.0 0.5 0.2 613.9 0.3 0.0 0.5 695.0 0.0 1.4 35.4 0.0 6.6 27.6 65.2 0.0 0.2 60.6 29.5 17.5 4.7 0.6 1.7 869.6 PLG ENSG00000122194 Plasminogen P00747 6 160702238-160754097 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted secreted proteins" "Blood coagulation, Fibrinolysis, Hemostasis, Tissue remodeling" "Hydrolase, Protease, Serine protease" "Cancer-related genes, Disease variant, FDA approved drug targets, Thrombophilia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 11 "liver: 2666.4" "Cell type enriched" "Detected in some" 7 "Hepatocytes: 1772.7" "Cancer enriched" "Detected in some" 84 "liver cancer: 180.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "CAB000668, CAB016678, HPA021602, HPA048823" Supported "Secreted to blood" NA NA 140000000000 45000000000 "Cluster 85: Liver - Metabolism" "Cluster 15: Hepatocytes - Hemostasis" "CAB000668: , CAB016678: AB_1621208, HPA021602: AB_1855453, HPA048823: AB_2680532" "unprognostic (1.70e-1)" "unprognostic (2.16e-3)" "unprognostic (2.44e-1)" "unprognostic (8.54e-3)" "unprognostic (1.41e-1)" "unprognostic (1.76e-3)" "unprognostic (6.28e-2)" "unprognostic (7.25e-2)" "prognostic favorable (4.22e-4)" "unprognostic (3.97e-3)" "unprognostic (5.21e-2)" "unprognostic (2.33e-2)" 0.4 0.4 0.3 0.2 0.4 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.3 0.2 0.0 0.1 2.4 0.5 0.1 0.2 0.3 240.9 2666.4 0.4 0.7 0.0 0.0 0.3 0.0 0.0 0.0 0.4 0.0 0.6 0.0 0.1 0.9 0.0 0.1 0.2 0.1 0.0 0.0 0.5 0.2 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.5 0.5 0.0 0.9 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.1 0.3 0.2 0.1 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.5 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.0 0.3 0.2 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 5.4 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.6 30.0 0.0 1.8 0.0 0.0 0.3 0.0 19.6 0.0 0.2 3.0 0.1 1.2 0.0 24.0 0.6 0.0 0.0 0.0 0.0 0.1 1.3 0.0 28.5 1772.7 0.1 0.0 0.5 0.0 0.0 35.4 0.0 0.2 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 235.7 1.5 0.1 0.0 0.4 0.2 0.4 0.4 0.0 0.0 0.0 2.3 0.1 0.0 0.0 PM20D1 "Cps1, FLJ32569" ENSG00000162877 "Peptidase M20 domain containing 1" Q6GTS8 1 205828025-205850132 "Enzymes, Predicted secreted proteins" "Hydrolase, Lyase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 9 "pancreas: 78.0;skin 1: 33.8" "Cell type enhanced" "Detected in some" "Exocrine glandular cells: 20.9;Gastric mucus-secreting cells: 7.1;Proximal tubular cells: 7.1" "Cancer enriched" "Detected in some" 32 "urothelial cancer: 30.2" "Not detected" "Not detected" "Immune cell enhanced" "Detected in some" "T-reg: 2.2" "Lineage enriched" "Detected in single" 6 "T-cells: 2.2" "Cell line enriched" "Detected in single" 9 "Karpas-707: 1.9" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "Secreted to digestive system" NA NA 3300000 "Cluster 35: T-regs - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 2: Karpas-707 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "unprognostic (1.16e-1)" "unprognostic (1.95e-1)" "unprognostic (1.30e-1)" "unprognostic (4.07e-2)" "unprognostic (4.83e-1)" "unprognostic (4.08e-3)" "unprognostic (1.17e-3)" "unprognostic (3.11e-1)" "unprognostic (1.20e-1)" "unprognostic (5.50e-2)" "unprognostic (5.81e-2)" "unprognostic (4.57e-2)" "unprognostic (7.79e-3)" "unprognostic (9.77e-2)" "unprognostic (1.45e-1)" "unprognostic (2.48e-1)" "unprognostic (1.68e-2)" 0.8 0.0 0.2 0.1 0.2 0.0 1.2 0.0 0.3 0.1 1.2 0.1 0.1 0.1 0.5 0.0 0.4 0.0 0.3 0.2 0.3 6.3 0.2 0.2 1.1 0.3 0.3 0.3 78.0 0.0 0.0 0.1 0.3 0.0 0.1 0.3 0.0 0.0 0.0 33.8 0.1 0.0 0.2 1.0 2.9 0.0 0.3 0.1 0.1 0.0 0.4 2.2 0.1 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.4 0.3 0.0 0.5 0.1 0.4 1.3 0.0 0.1 0.1 0.4 0.0 0.0 0.1 0.0 2.2 0.3 0.2 0.2 0.0 0.3 0.2 0.3 0.3 0.3 0.3 0.2 0.3 0.3 0.8 0.0 0.0 1.6 1.1 0.0 0.0 0.0 0.6 0.5 0.0 0.0 1.5 0.0 0.0 0.0 2.1 0.0 0.9 0.1 0.0 0.1 0.0 0.1 0.1 0.3 0.0 0.4 3.2 20.9 0.3 0.5 7.1 0.0 0.0 0.0 0.7 0.3 0.1 0.0 3.5 0.2 0.0 1.3 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 1.0 1.5 1.5 0.6 0.0 0.0 1.8 0.2 0.0 7.1 0.0 0.8 0.0 0.2 0.2 0.1 0.1 0.0 0.1 0.0 0.9 2.4 0.0 0.1 PM20D2 "ACY1L2, bA63L7.3" ENSG00000146281 "Peptidase M20 domain containing 2" Q8IYS1 6 89146055-89165565 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "Daudi: 88.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030325, HPA030326, HPA030327" Approved Enhanced Nucleoplasm NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 32: U-937 - Innate immune response" "Cluster 37: Myocytes - Muscle contraction" Nucleoplasm "HPA030325: , HPA030326: AB_2673429, HPA030327: AB_10603129" "unprognostic (3.60e-2)" "unprognostic (1.40e-1)" "unprognostic (6.36e-2)" "unprognostic (3.18e-3)" "unprognostic (3.22e-2)" "unprognostic (2.73e-1)" "unprognostic (1.13e-3)" "unprognostic (8.60e-2)" "unprognostic (1.04e-1)" "unprognostic (5.86e-2)" "unprognostic (2.27e-2)" "unprognostic (1.04e-1)" "unprognostic (9.99e-2)" "unprognostic (6.84e-2)" "unprognostic (1.28e-1)" "unprognostic (1.32e-1)" "unprognostic (1.31e-1)" 5.4 6.0 4.5 8.6 4.8 9.2 9.4 7.3 5.2 9.4 10.1 13.6 8.8 11.8 8.2 8.9 12.9 6.5 8.2 4.5 6.1 9.2 4.8 4.9 11.2 4.6 4.0 22.3 10.7 9.2 8.2 4.8 3.3 25.4 10.1 14.1 7.8 8.5 29.1 12.6 8.9 10.4 3.4 6.1 8.5 3.0 5.9 13.6 12.5 16.3 10.8 10.9 8.1 3.9 30.7 13.4 11.8 18.3 3.8 2.3 0.8 15.1 15.0 22.1 28.2 15.7 14.6 88.3 18.0 3.3 18.8 11.5 24.3 12.1 49.9 27.8 30.8 18.0 8.0 14.9 4.2 52.4 13.9 3.8 8.8 8.4 17.7 18.0 5.4 26.2 7.0 46.3 6.9 4.7 33.3 41.3 4.8 26.4 13.2 54.5 58.5 65.1 24.8 5.7 33.1 23.0 9.1 14.5 15.1 15.3 0.1 45.5 8.8 0.4 13.3 4.6 32.0 24.5 38.3 19.0 6.1 44.3 2.1 0.8 0.3 1.2 0.7 0.2 1.2 1.5 0.9 1.3 0.6 1.0 1.4 1.2 1.0 1.9 0.2 0.9 0.1 0.6 4.5 4.8 7.3 5.2 4.5 6.1 4.6 4.0 3.3 3.4 5.9 3.9 7.3 9.6 10.3 21.5 14.3 30.2 23.8 7.4 17.1 28.5 21.6 16.5 23.4 27.1 11.5 16.5 31.3 2.8 7.1 6.8 5.9 11.9 5.5 15.1 13.6 8.8 10.8 18.3 29.5 10.4 2.4 12.0 15.3 20.6 6.3 17.3 8.9 9.2 3.4 8.4 38.9 21.4 6.1 6.7 17.9 9.0 24.5 6.8 17.8 26.2 14.6 11.1 4.1 32.2 27.3 18.1 7.9 19.2 15.5 44.4 5.2 15.6 12.2 24.3 6.6 26.9 20.3 5.3 6.6 24.4 31.7 1.2 10.5 5.3 28.4 17.4 PMPCA "Alpha-MPP, CLA1, INPP5E, KIAA0123, SCAR2" ENSG00000165688 "Peptidase, mitochondrial processing subunit alpha" Q10713 9 136410641-136423761 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Disease variant, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021648, HPA063735" Supported Enhanced Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 18: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Mitochondria "HPA021648: AB_1855491, HPA063735: AB_2685108" "unprognostic (9.80e-2)" "unprognostic (1.96e-2)" "unprognostic (4.03e-1)" "unprognostic (1.69e-2)" "unprognostic (4.01e-2)" "unprognostic (8.19e-2)" "unprognostic (6.09e-2)" "unprognostic (1.19e-2)" "unprognostic (1.97e-1)" "unprognostic (3.32e-2)" "prognostic favorable (8.00e-5)" "unprognostic (9.47e-3)" "prognostic favorable (2.14e-6)" "unprognostic (4.27e-3)" "unprognostic (1.57e-2)" "unprognostic (2.40e-1)" "unprognostic (3.54e-2)" 29.2 58.1 27.0 20.6 27.6 31.4 27.1 27.0 34.6 29.2 36.8 32.2 24.8 26.8 10.4 34.5 27.5 17.9 73.2 28.0 27.3 37.3 110.8 25.4 27.1 27.1 27.6 29.3 28.8 26.9 38.8 20.8 27.9 31.8 15.3 8.8 28.4 16.1 69.2 37.6 30.6 15.3 25.6 38.2 35.3 37.8 27.9 21.4 29.4 50.0 17.0 28.0 27.8 26.7 48.7 87.7 41.8 84.5 30.8 45.0 63.2 49.3 39.6 67.2 48.9 101.1 56.5 67.4 50.5 50.3 36.2 110.2 77.9 72.0 30.0 97.2 92.8 54.6 113.2 123.6 53.9 71.7 44.9 66.3 48.9 52.6 27.0 38.2 58.0 61.2 140.2 43.4 42.6 132.1 68.1 90.1 85.4 86.2 82.2 83.0 59.1 149.9 46.3 33.9 85.4 56.1 66.6 92.9 58.6 28.6 127.6 95.5 48.2 47.8 50.7 39.8 63.8 26.2 37.4 73.5 62.9 61.3 43.9 37.4 50.5 36.5 53.2 51.9 51.4 52.5 49.0 57.2 61.7 48.8 57.9 50.2 11.9 67.2 51.5 31.4 52.7 62.2 27.0 27.6 27.0 34.6 28.0 27.3 27.1 27.6 27.9 25.6 27.9 26.7 17.3 16.0 26.7 14.7 24.2 27.5 40.2 65.0 27.9 24.7 19.3 15.2 35.9 15.7 32.8 22.0 22.9 103.1 22.5 28.0 49.0 32.9 24.6 25.6 23.5 21.7 20.8 23.5 13.8 30.7 50.4 23.7 21.9 26.2 24.7 44.2 19.6 57.2 37.8 18.5 11.4 24.2 44.7 19.2 14.6 15.8 19.0 17.4 16.0 6.5 21.0 22.9 14.4 8.5 8.0 31.6 20.9 22.6 26.6 22.6 25.6 46.9 22.6 27.4 39.5 22.4 27.9 37.7 42.4 23.2 26.9 103.8 21.7 77.0 38.6 28.5 PMPCB "MPPB, MPPP52" ENSG00000105819 "Peptidase, mitochondrial processing subunit beta" O75439 7 103297435-103329511 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040674, HPA074168" Approved Enhanced Mitochondria No No 19000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Mitochondria "HPA040674: AB_10961998, HPA074168: AB_2686671" "prognostic favorable (2.79e-4)" "unprognostic (3.11e-1)" "unprognostic (7.18e-3)" "unprognostic (3.03e-1)" "unprognostic (3.65e-2)" "unprognostic (1.72e-1)" "unprognostic (1.06e-1)" "unprognostic (7.67e-2)" "unprognostic (7.74e-2)" "unprognostic (1.21e-1)" "unprognostic (1.38e-1)" "unprognostic (1.42e-3)" "prognostic favorable (2.95e-8)" "unprognostic (2.59e-2)" "unprognostic (9.79e-2)" "unprognostic (2.40e-1)" "unprognostic (4.39e-2)" 30.8 42.0 16.9 22.3 18.2 53.5 32.5 18.9 22.1 33.3 24.7 33.4 38.0 29.9 26.2 27.7 29.3 25.1 44.9 18.8 18.1 47.4 46.1 22.6 36.4 16.5 16.6 35.4 41.1 39.7 22.4 25.8 17.6 31.5 33.2 25.4 30.6 28.1 34.8 33.2 32.4 26.3 17.2 28.2 35.8 26.7 17.4 30.2 33.4 38.2 33.9 29.3 28.4 19.9 30.2 42.8 49.9 69.4 28.5 57.1 38.0 26.7 45.6 54.3 62.8 47.7 33.7 76.9 41.7 47.9 58.0 37.5 59.7 43.2 49.2 26.4 69.4 26.4 74.0 61.6 35.0 35.0 30.6 53.4 40.5 41.8 39.6 51.3 28.8 55.9 52.5 77.9 48.5 71.1 59.2 82.0 59.2 60.4 52.4 42.7 34.3 79.4 50.3 54.2 62.2 76.5 37.3 108.6 55.8 49.5 45.3 49.1 24.9 48.3 57.9 85.1 52.3 57.4 79.9 61.8 35.7 59.3 38.2 16.7 19.3 13.2 18.3 21.4 20.1 25.9 21.1 18.5 24.7 19.3 26.1 21.7 5.7 17.9 19.7 12.6 30.2 22.3 16.9 18.2 18.9 22.1 18.8 18.1 16.5 16.6 17.6 17.2 17.4 19.9 32.0 32.1 36.9 27.1 54.5 36.7 68.2 123.2 51.8 31.6 41.3 37.3 70.4 41.5 70.7 27.6 22.9 125.6 55.9 35.8 72.4 75.6 106.3 38.4 37.0 37.1 27.1 65.8 36.8 73.2 61.3 42.5 35.7 35.0 60.2 49.9 31.1 53.7 54.6 23.5 33.9 48.1 75.3 49.4 30.7 24.0 51.9 42.4 26.6 18.7 92.5 35.8 58.7 35.7 44.4 59.7 45.4 49.7 56.1 35.2 60.4 127.5 58.2 37.9 65.7 48.6 73.5 125.4 56.4 47.1 37.5 124.9 55.9 63.3 59.1 62.2 PRCP "HUMPCP, PCP" ENSG00000137509 Prolylcarboxypeptidase P42785 11 82822936-82970584 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hepatic stellate cells: 348.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "ASC diff: 463.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017065, HPA071115" Approved Supported Vesicles "Intracellular and membrane" NA NA 42000000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Vesicles "HPA017065: AB_1855676, HPA071115: " "unprognostic (3.24e-1)" "unprognostic (2.25e-1)" "unprognostic (1.76e-1)" "unprognostic (1.51e-1)" "unprognostic (2.54e-1)" "unprognostic (1.33e-2)" "unprognostic (9.22e-2)" "unprognostic (1.42e-1)" "unprognostic (7.97e-2)" "unprognostic (2.61e-1)" "unprognostic (2.70e-1)" "unprognostic (1.88e-2)" "prognostic favorable (2.65e-6)" "unprognostic (7.16e-2)" "unprognostic (1.73e-2)" "unprognostic (3.49e-1)" "unprognostic (4.07e-1)" 74.8 87.3 81.1 57.8 82.1 37.7 70.0 84.3 109.1 91.9 95.0 49.3 28.6 62.9 81.4 62.1 57.0 64.3 70.0 76.6 85.6 144.7 151.9 58.1 92.1 84.4 82.1 53.5 37.9 78.4 34.5 152.8 80.9 52.5 46.6 21.9 85.6 55.5 15.9 54.1 31.8 80.8 89.0 54.0 32.0 41.8 86.0 33.7 63.7 28.5 85.0 100.2 57.5 86.7 34.9 41.8 49.6 121.0 463.5 146.7 67.1 67.5 131.9 70.9 97.0 103.5 70.7 55.9 100.7 117.9 72.6 53.2 53.7 45.2 72.0 43.9 38.3 37.7 56.5 76.7 86.2 31.0 124.7 122.0 39.3 72.7 68.6 166.5 224.0 26.3 39.1 69.8 72.7 19.5 4.9 171.7 33.9 90.3 31.1 27.1 97.0 65.1 118.0 71.2 24.0 51.9 101.9 60.2 41.5 80.6 66.6 49.6 65.0 78.8 77.4 71.1 33.5 64.2 113.6 46.3 32.9 41.7 44.5 53.5 76.9 50.9 13.7 79.0 16.1 31.7 14.0 15.9 140.2 34.2 12.0 17.4 89.0 34.7 64.8 27.9 14.8 49.6 81.1 82.1 84.3 109.1 76.6 85.6 84.4 82.1 80.9 89.0 86.0 86.7 86.9 19.2 12.9 58.8 45.5 31.4 41.5 53.4 25.0 11.7 26.2 25.1 26.6 37.1 25.2 62.5 2.1 65.1 29.0 9.8 29.4 32.9 44.9 17.4 37.7 180.4 19.7 13.7 42.2 12.0 120.1 73.6 23.9 29.9 12.7 18.2 348.7 65.4 80.7 16.8 38.5 19.1 14.2 152.9 118.9 47.6 44.1 88.0 71.2 33.7 79.5 53.5 28.8 34.7 10.5 8.2 10.2 46.3 62.2 23.3 3.9 83.8 9.1 5.3 65.7 25.5 25.6 60.8 6.3 54.3 34.9 52.9 22.3 27.7 20.9 39.2 PREP ENSG00000085377 "Prolyl endopeptidase" P48147 6 105273218-105454062 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 84.8" "Cell type enhanced" "Detected in many" "Excitatory neurons: 79.7;Syncytiotrophoblasts: 67.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025414, HPA031388, HPA031389, HPA031390" Supported Supported Cytosol NA NA 1700000 "Cluster 27: Non-specific - Gene expression" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 30: Epithelial cell lines - Translation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "CAB025414: , HPA031388: AB_2673855, HPA031389: AB_2673856, HPA031390: AB_2673857" "unprognostic (3.05e-2)" "unprognostic (9.09e-3)" "unprognostic (2.85e-2)" "unprognostic (5.46e-2)" "unprognostic (3.36e-1)" "prognostic unfavorable (3.33e-4)" "unprognostic (2.63e-3)" "unprognostic (2.39e-1)" "unprognostic (6.78e-2)" "unprognostic (5.81e-2)" "unprognostic (2.66e-2)" "unprognostic (1.15e-1)" "unprognostic (4.47e-3)" "unprognostic (2.74e-2)" "unprognostic (8.98e-2)" "unprognostic (6.59e-2)" "unprognostic (2.33e-1)" 17.3 17.4 7.2 14.6 8.1 14.3 17.7 7.4 12.0 15.2 7.8 32.1 23.6 15.8 12.1 21.1 13.0 8.7 22.5 8.8 7.3 11.3 19.0 16.2 13.6 6.7 7.7 16.0 19.2 20.5 13.0 17.8 6.8 11.6 37.5 15.4 18.6 9.0 84.8 33.4 25.6 15.3 6.6 14.3 18.7 21.4 8.8 16.4 12.3 46.9 16.2 21.4 17.5 8.5 22.3 26.9 27.9 32.1 63.1 37.1 27.7 28.6 27.0 37.2 39.0 35.9 14.2 28.5 26.8 33.9 35.0 33.3 41.8 86.5 42.7 41.8 37.4 38.1 21.7 40.0 25.3 40.5 26.2 35.8 53.4 27.6 71.7 28.0 35.4 50.1 67.4 49.8 45.5 38.8 25.8 41.4 27.9 44.2 25.0 41.1 48.4 18.3 28.2 53.8 36.0 51.8 25.3 42.0 21.7 35.3 17.9 61.9 36.1 17.3 23.9 21.6 36.2 14.2 9.7 38.5 30.4 42.6 56.6 5.5 15.2 8.4 16.3 16.8 16.8 9.3 14.2 17.1 16.5 6.9 12.9 15.5 0.8 19.9 22.7 7.0 13.6 13.5 7.2 8.1 7.4 12.0 8.8 7.3 6.7 7.7 6.8 6.6 8.8 8.5 6.3 3.2 6.7 22.9 10.1 10.8 6.8 12.0 5.7 5.1 6.0 5.5 14.8 7.2 13.6 7.3 14.6 28.2 14.5 19.3 5.9 10.4 1.4 6.6 15.1 10.1 19.3 11.2 79.7 11.7 35.9 10.6 24.5 11.6 13.4 11.2 7.5 15.1 15.0 13.5 48.3 29.4 10.2 14.2 10.8 3.2 10.8 13.3 5.4 27.2 19.1 3.3 5.2 28.6 18.7 18.0 29.1 9.1 11.0 5.3 18.5 8.8 4.8 10.4 0.0 8.3 10.3 3.9 18.8 12.9 8.5 67.9 16.1 14.4 38.2 8.5 PREPL KIAA0436 ENSG00000138078 "Prolyl endopeptidase like" Q4J6C6 2 44316281-44361862 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 243.1;Inhibitory neurons: 219.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063238 Approved NA NA "Cluster 44: Non-specific - Transcription" "Cluster 58: Brain - Synaptic function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA063238: AB_2684967" "unprognostic (5.60e-3)" "unprognostic (9.81e-2)" "unprognostic (4.51e-2)" "unprognostic (4.65e-3)" "unprognostic (2.22e-1)" "unprognostic (8.53e-2)" "unprognostic (5.98e-3)" "unprognostic (4.38e-3)" "unprognostic (2.27e-1)" "unprognostic (2.72e-2)" "unprognostic (1.52e-2)" "unprognostic (4.67e-2)" "unprognostic (2.33e-2)" "unprognostic (3.79e-1)" "unprognostic (1.87e-1)" "unprognostic (1.76e-1)" "unprognostic (1.75e-1)" 26.2 50.9 64.6 18.4 67.4 5.5 31.9 42.9 133.1 35.9 27.5 24.4 26.1 47.2 70.9 22.9 33.6 28.4 62.7 73.1 93.1 62.5 21.6 24.5 17.4 45.3 26.0 49.8 25.2 54.4 52.5 21.4 41.7 37.3 29.4 123.8 26.2 33.1 34.3 22.3 27.9 34.1 34.0 23.1 26.4 28.2 53.4 19.1 61.3 51.3 17.9 23.6 23.9 58.4 41.2 31.7 35.3 45.3 55.7 58.0 26.8 45.1 34.6 32.0 27.4 34.1 28.4 52.3 61.2 47.5 36.6 34.6 50.6 33.0 61.0 48.7 36.2 35.5 24.2 26.3 40.0 35.8 32.5 37.9 64.6 61.8 50.1 62.9 31.4 24.3 45.6 72.6 43.6 22.2 39.1 17.4 33.4 52.8 35.1 30.1 42.8 38.0 61.4 24.0 58.3 46.5 28.9 30.6 67.4 33.9 41.4 27.6 32.8 56.3 32.1 44.6 31.0 40.2 28.2 34.3 65.9 40.1 42.5 6.9 4.4 3.5 7.9 4.9 11.2 8.5 7.3 8.5 6.3 7.0 10.7 8.7 1.3 11.1 4.3 2.9 8.8 5.8 64.6 67.4 42.9 133.1 73.1 93.1 45.3 26.0 41.7 34.0 53.4 58.4 16.3 32.1 37.4 83.2 34.0 13.0 16.0 13.2 21.6 89.1 33.4 26.7 88.1 32.9 21.1 64.4 47.9 8.7 30.0 20.4 39.2 17.4 21.1 40.1 36.7 18.7 33.0 13.9 243.1 23.6 4.9 29.5 28.1 32.1 13.3 21.9 16.8 32.8 11.6 144.7 219.9 24.2 18.3 13.5 7.5 10.0 35.4 14.2 17.8 55.3 12.8 41.4 32.0 81.4 126.2 13.6 20.8 33.1 21.8 16.3 12.2 38.8 35.5 63.2 19.7 44.5 27.2 29.2 28.7 16.3 14.8 8.8 29.1 26.0 17.1 10.7 PROC ENSG00000115718 "Protein C, inactivator of coagulation factors Va and VIIIa" P04070 2 127418427-127429242 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Blood coagulation, Hemostasis" "Hydrolase, Protease, Serine protease" "Cancer-related genes, Disease variant, FDA approved drug targets, Thrombophilia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 40 "liver: 598.5" "Cell type enriched" "Detected in some" 5 "Hepatocytes: 432.9" "Cancer enriched" "Detected in many" 22 "liver cancer: 118.3" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in some" 9 "plasmacytoid DC: 59.7" "Lineage enriched" "Detected in many" 9 "dendritic cells: 59.7" "Cell line enriched" "Detected in some" 16 "Hep G2: 156.1" "Low region specificity" "Detected in all" "HPA005550, CAB016721, CAB016792" Approved "Secreted to blood" NA NA 5200000000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 62: Liver - Hemostasis" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "CAB016721: , CAB016792: , HPA005550: AB_1079687" "unprognostic (2.46e-2)" "unprognostic (1.08e-1)" "unprognostic (1.38e-1)" "unprognostic (1.58e-1)" "unprognostic (6.64e-2)" "unprognostic (3.13e-2)" "unprognostic (4.90e-3)" "unprognostic (2.63e-1)" "unprognostic (1.67e-1)" "unprognostic (3.29e-1)" "unprognostic (3.74e-3)" "unprognostic (2.56e-2)" "unprognostic (8.12e-3)" "unprognostic (2.01e-2)" "unprognostic (1.71e-1)" "unprognostic (4.60e-3)" "unprognostic (8.06e-2)" 0.2 0.0 0.6 0.1 1.1 1.1 0.1 0.6 1.0 0.4 0.0 1.0 0.8 0.1 0.1 0.1 0.2 0.6 0.1 0.6 1.0 14.8 598.5 0.2 0.6 1.6 0.8 0.2 0.3 0.0 0.3 0.1 1.5 0.2 0.6 0.2 0.2 0.1 0.2 0.6 0.8 0.0 0.4 0.4 2.6 0.1 0.8 0.6 0.2 0.0 0.3 0.4 0.2 1.1 0.1 2.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 4.1 0.0 0.9 0.1 0.4 9.5 0.0 0.3 0.0 0.0 0.2 0.1 7.8 156.1 0.0 0.3 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.6 0.0 0.0 0.0 0.0 0.3 1.6 0.4 2.3 0.7 0.0 0.1 0.0 0.0 0.9 0.4 0.0 1.0 0.1 0.0 0.1 0.2 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.3 0.1 0.0 0.0 6.3 0.0 0.0 59.7 0.0 0.3 0.6 1.1 0.6 1.0 0.6 1.0 1.6 0.8 1.5 0.4 0.8 1.1 0.0 0.0 0.0 0.3 4.1 0.8 0.4 11.2 0.0 0.0 0.1 0.0 0.4 47.1 1.2 0.0 0.0 0.0 24.0 3.9 5.9 0.5 0.1 3.4 0.1 0.6 10.3 18.7 0.1 0.2 0.0 0.7 2.0 0.2 0.0 0.0 12.1 432.9 3.7 0.0 0.5 9.3 0.0 9.3 4.0 0.1 0.0 2.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.7 8.1 0.0 0.0 0.0 3.8 84.8 3.4 0.0 0.0 0.2 0.3 0.1 0.2 0.0 0.1 0.1 1.1 0.0 1.8 0.3 PROZ PZ ENSG00000126231 "Protein Z, vitamin K dependent plasma glycoprotein" P22891 13 113158648-113172386 "Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted secreted proteins" "Blood coagulation, Hemostasis" "Serine protease homolog" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 8 "liver: 109.2" "Group enriched" "Detected in some" 52 "Hepatocytes: 63.5;Proximal tubular cells: 20.5" "Cancer enriched" "Detected in single" 27 "liver cancer: 12.1" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HaCaT: 2.2;Hep G2: 3.6" "Not detected" "Not detected" HPA052006 Supported "Secreted to blood" NA NA 1720000000 650000000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA052006: AB_2681691" "unprognostic (5.03e-2)" "unprognostic (4.05e-2)" "unprognostic (1.11e-1)" "unprognostic (2.36e-1)" "unprognostic (6.48e-2)" "unprognostic (1.39e-1)" "prognostic favorable (3.46e-4)" "unprognostic (4.10e-1)" "unprognostic (2.21e-1)" "unprognostic (2.50e-1)" "unprognostic (5.20e-2)" "unprognostic (2.87e-1)" "unprognostic (9.83e-2)" "unprognostic (5.63e-2)" "unprognostic (1.41e-1)" "unprognostic (9.99e-2)" "unprognostic (2.51e-4)" 0.1 0.3 0.1 0.3 0.0 0.1 0.0 0.7 0.2 0.2 0.1 0.2 0.2 0.1 0.0 0.1 0.2 0.2 0.1 0.0 0.0 14.4 109.2 0.1 0.3 0.0 0.0 0.1 0.7 0.0 1.2 0.0 0.0 0.4 0.0 0.1 0.3 0.0 0.0 0.5 0.3 0.0 0.0 0.4 0.5 1.7 0.0 0.0 0.2 0.0 0.0 0.1 0.1 0.0 0.4 0.6 0.3 0.4 0.0 0.0 0.2 0.7 0.0 0.0 0.0 1.4 0.8 0.3 0.0 0.0 0.1 2.2 0.0 0.0 0.0 0.4 1.1 0.4 1.6 3.6 0.0 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.5 0.3 0.0 0.5 0.3 0.4 0.8 1.4 0.1 0.6 0.1 0.1 0.0 0.5 1.3 0.0 0.0 0.1 0.6 0.7 0.0 0.4 0.3 0.3 0.0 0.3 0.1 0.7 0.4 0.3 0.7 0.4 0.3 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.1 0.0 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 63.5 0.0 0.0 0.1 0.6 0.0 0.8 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 20.5 0.1 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.2 0.1 0.0 0.1 PRSS1 TRY1 ENSG00000204983 "Serine protease 1" P07477 7 142749468-142753076 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" Digestion "Hydrolase, Protease, Serine protease" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 1923 "pancreas: 341429.7" "Cell type enriched" "Detected in some" 28 "Exocrine glandular cells: 57138.3" "Cancer enriched" "Detected in many" 224 "pancreatic cancer: 1920.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 23 "OE19: 10.6;RPMI-8226: 4.5;U-2 OS: 2.8" "CAB025487, CAB025538, HPA062452, HPA063471" Enhanced Approved "Endoplasmic reticulum,Vesicles" "Secreted to digestive system" NA NA 100000000000 "Cluster 35: T-regs - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 21: OE19 - Mitochondria" "Cluster 1: Pancreatic cells - Digestion" Vesicles "Endoplasmic reticulum" "CAB025487: , CAB025538: , HPA062452: AB_2684768, HPA063471: AB_2685017" "unprognostic (6.55e-5)" "unprognostic (5.28e-1)" "unprognostic (7.58e-2)" "prognostic unfavorable (6.41e-6)" "unprognostic (8.26e-2)" "prognostic favorable (7.05e-4)" "unprognostic (1.35e-1)" "unprognostic (3.93e-2)" "unprognostic (1.96e-1)" "prognostic favorable (4.91e-4)" "unprognostic (3.12e-1)" 45.2 9.9 0.0 4.7 0.0 0.0 25.7 0.0 0.0 19.9 0.0 11.2 54.5 8.9 0.8 15.2 5.6 0.0 51.0 0.0 0.0 9.6 29.7 6.4 6.5 0.0 0.0 177.5 341429.7 0.1 10.3 13.9 0.0 15.2 0.0 0.0 44.2 4.2 8.9 12.1 12.7 0.0 0.0 13.4 77.1 6.9 0.0 0.0 6.4 0.0 0.0 4.7 8.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.6 0.0 0.0 0.0 4.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 100.7 0.0 0.1 0.0 3.6 0.0 0.0 0.0 57138.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.5 0.0 0.0 119.4 0.6 0.0 0.0 0.0 1985.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 3.3 0.0 0.0 0.0 0.6 0.0 0.1 0.1 0.2 0.2 PRSS12 "BSSP-3, MRT1" ENSG00000164099 "Serine protease 12" P56730 4 118280038-118353003 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Club cells: 34.3;Cytotrophoblasts: 48.0;Respiratory ciliated cells: 76.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 70.2;SH-SY5Y: 215.4;THP-1: 100.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA035054 Uncertain Approved "Nucleoplasm,Actin filaments" "Secreted - unknown location" NA NA "Cluster 46: Fibroblasts - ECM organization" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 47: Cytotrophoblasts - Unknown function" "Actin filaments" Nucleoplasm "HPA035054: AB_10603990" "unprognostic (4.30e-2)" "unprognostic (1.04e-2)" "unprognostic (2.55e-1)" "unprognostic (4.41e-2)" "prognostic favorable (2.66e-4)" "prognostic favorable (1.03e-4)" "unprognostic (4.21e-1)" "unprognostic (3.48e-2)" "unprognostic (7.83e-2)" "unprognostic (6.38e-2)" "unprognostic (1.09e-1)" "unprognostic (1.27e-1)" "unprognostic (2.41e-2)" "unprognostic (1.29e-1)" "unprognostic (1.85e-1)" "unprognostic (9.55e-2)" "unprognostic (1.09e-1)" 0.6 0.5 1.4 1.6 0.9 0.1 2.2 0.6 1.3 14.5 14.4 6.7 2.7 1.9 0.6 3.2 10.5 9.8 0.0 2.7 0.5 0.8 0.6 7.6 0.1 0.5 1.9 1.6 7.7 0.1 0.6 10.6 0.7 1.4 6.4 0.3 2.5 2.0 0.2 5.9 4.8 1.3 0.5 0.0 9.2 10.0 1.2 1.0 0.2 1.2 5.7 3.8 12.6 0.5 5.2 0.2 1.8 0.0 0.2 13.3 0.1 46.0 41.5 9.7 16.1 0.1 18.7 0.0 0.2 70.2 4.9 0.8 31.1 9.5 12.7 0.2 7.2 0.0 3.6 0.0 1.4 0.0 0.2 4.1 17.5 3.4 9.9 31.2 0.1 0.6 0.0 0.0 8.0 0.3 0.5 9.6 2.2 36.4 2.9 0.0 38.7 0.0 0.0 7.0 5.1 215.4 0.0 0.2 3.0 30.9 0.0 100.6 0.0 19.2 2.8 12.2 9.1 1.0 0.1 0.0 1.0 3.3 11.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.9 0.6 1.3 2.7 0.5 0.5 1.9 0.7 0.5 1.2 0.5 0.3 6.4 4.6 0.7 0.2 8.4 0.8 16.4 2.2 0.6 0.8 0.8 1.4 10.0 34.3 1.8 0.0 48.0 0.0 26.8 0.0 0.4 9.9 19.7 16.8 0.9 5.3 0.0 10.5 10.2 4.5 7.1 17.9 2.6 7.0 3.3 0.0 0.4 3.8 0.0 14.3 2.7 10.2 0.0 4.2 18.3 0.0 0.4 5.4 7.5 0.0 0.0 0.0 0.5 0.2 8.1 12.8 0.0 0.2 0.4 9.4 0.6 76.1 0.2 0.0 0.6 4.9 10.1 13.3 3.6 4.3 11.9 0.7 21.8 5.3 4.7 PRSS16 TSSP ENSG00000112812 "Serine protease 16" Q9NQE7 6 27247701-27256624 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enriched" "Detected in many" 58 "lymphoid tissue: 826.7" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 42.1;Extravillous trophoblasts: 25.4;Syncytiotrophoblasts: 31.7" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "memory B-cell: 2.1" "Lineage enhanced" "Detected in single" "B-cells: 2.1" "Cell line enhanced" "Detected in many" "hTCEpi: 20.4;RPMI-8226: 11.5" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Secreted in other tissues" NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 63: T-cells - Adaptive immune response" "Cluster 30: Epithelial cell lines - Translation" "Cluster 47: Cytotrophoblasts - Unknown function" "unprognostic (1.50e-1)" "unprognostic (6.95e-2)" "unprognostic (1.91e-2)" "unprognostic (1.51e-1)" "unprognostic (2.21e-2)" "unprognostic (1.74e-2)" "unprognostic (9.21e-3)" "unprognostic (1.57e-1)" "unprognostic (7.89e-2)" "prognostic favorable (6.46e-5)" "unprognostic (1.57e-1)" "unprognostic (3.49e-2)" "unprognostic (5.42e-2)" "unprognostic (1.95e-1)" "unprognostic (5.49e-2)" "unprognostic (2.10e-1)" "unprognostic (1.62e-2)" 0.2 0.4 0.0 0.3 0.0 0.0 6.0 0.1 0.3 3.6 0.0 5.7 4.4 0.7 13.5 2.9 5.6 4.0 0.0 0.1 0.0 1.8 0.0 3.8 0.1 0.0 0.0 2.5 14.1 7.8 1.4 4.1 0.1 3.2 6.7 0.1 7.5 4.2 0.0 5.1 3.3 0.2 0.0 0.3 4.8 1.0 0.0 826.7 13.1 0.0 1.4 2.5 1.0 0.0 3.2 0.2 0.0 0.0 0.0 0.0 4.2 0.0 0.0 0.0 0.1 3.8 4.7 0.0 0.7 0.0 0.0 1.5 2.7 3.2 0.0 0.1 0.5 0.0 0.0 0.0 0.0 2.1 0.5 0.0 20.4 0.0 4.1 0.5 0.0 1.7 2.5 1.9 0.0 1.2 0.5 0.0 0.7 2.1 0.5 0.0 0.0 11.5 2.4 3.6 0.0 0.0 1.4 3.2 0.0 4.5 2.0 0.9 0.0 0.0 0.7 0.0 0.0 0.7 1.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.7 0.0 0.7 2.1 0.9 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.3 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 9.6 7.7 0.0 2.6 6.4 10.8 4.6 8.6 0.0 16.6 9.5 0.4 15.7 4.6 14.7 0.0 42.1 0.2 22.9 1.9 10.0 0.6 2.5 0.8 0.4 4.2 0.0 0.7 17.6 25.4 0.7 12.8 8.0 5.7 0.1 0.0 0.0 4.0 0.0 0.2 20.0 14.2 0.3 0.4 0.5 0.6 0.3 5.4 0.0 0.2 1.2 0.0 0.0 0.1 9.4 18.7 0.0 13.7 6.9 16.5 0.7 3.4 0.0 0.0 0.0 1.2 2.0 6.1 8.6 6.5 31.7 1.1 0.0 14.9 8.5 PRSS2 TRY2 ENSG00000275896 "Serine protease 2" P07478 7 142760398-142774564 "Enzymes, Human disease related genes, Plasma proteins, Predicted secreted proteins" Digestion "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 452 "pancreas: 239420.0" "Cell type enriched" "Detected in some" 11 "Exocrine glandular cells: 108258.7" "Cancer enriched" "Detected in many" 72 "pancreatic cancer: 3463.4" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "basophil: 4.1;T-reg: 2.9" "Group enriched" "Detected in many" 8 "granulocytes: 4.1;T-cells: 2.9" "Cell line enhanced" "Detected in some" "OE19: 21.0;RPMI-8226: 67.5;U-2 OS: 15.2" "HPA062452, HPA063471" Supported Approved "Endoplasmic reticulum,Vesicles" "Secreted to digestive system" NA NA 890000000 "Cluster 41: Basophils - Cellular respiration" "Cluster 25: Pancreas - Digestion" "Cluster 25: RPMI-8226 - Immune response" "Cluster 1: Pancreatic cells - Digestion" Vesicles "Endoplasmic reticulum" "HPA062452: AB_2684768, HPA063471: AB_2685017" "prognostic favorable (2.32e-4)" "unprognostic (3.80e-1)" "unprognostic (2.46e-1)" "unprognostic (3.30e-3)" "unprognostic (1.99e-2)" "unprognostic (3.06e-2)" "unprognostic (1.36e-1)" "unprognostic (4.62e-3)" "unprognostic (1.48e-1)" "unprognostic (4.65e-2)" "unprognostic (1.55e-3)" "unprognostic (1.58e-2)" "unprognostic (3.50e-1)" "unprognostic (5.36e-3)" "unprognostic (1.18e-1)" 65.1 12.5 0.1 0.2 0.1 3.2 25.4 0.0 0.1 27.6 0.0 12.6 358.5 11.4 0.0 18.2 9.6 0.1 25.0 0.0 0.0 9.4 32.2 8.2 1.3 0.0 0.0 64.9 239420.0 0.0 13.4 8.1 0.0 17.2 0.0 0.0 25.4 0.9 10.1 11.3 529.2 0.1 0.0 16.9 54.7 8.6 0.0 0.9 8.3 0.0 0.0 7.0 10.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.6 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 2.4 4.4 0.5 0.0 0.0 0.0 1.9 0.0 21.0 0.0 0.0 0.0 67.5 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.2 0.9 3.8 0.0 2.9 0.6 0.0 0.0 0.0 4.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 2.9 0.2 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 378.7 0.0 0.4 0.1 11.4 0.0 0.0 0.0 108258.7 0.0 0.3 4.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.7 0.0 0.0 0.0 0.0 0.0 15.5 0.0 0.0 348.9 0.0 0.0 0.0 0.0 9565.7 8.9 0.0 0.1 0.0 60.0 0.1 0.0 0.0 0.0 0.0 36.3 0.0 0.0 0.0 0.0 0.0 0.1 0.1 85.4 0.2 PRSS21 "ESP-1, TEST1" ENSG00000007038 "Serine protease 21" Q9Y6M0 16 2817180-2826304 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 4 "testis: 84.6" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 84.1;Early spermatids: 111.0;Late spermatids: 349.7;Spermatocytes: 453.2;Spermatogonia: 270.2" "Cancer enhanced" "Detected in many" "ovarian cancer: 23.9" "Not detected" "Not detected" "Group enriched" "Detected in many" 5 "basophil: 16.1;eosinophil: 33.0" "Lineage enriched" "Detected in all" 7 "granulocytes: 33.0" "Cell line enhanced" "Detected in some" "CAPAN-2: 25.0;HEL: 28.5;HeLa: 71.0;K-562: 34.3;U-698: 104.8" "Not detected" "Not detected" "Region enriched" "Detected in single" 38 "basal ganglia: 8.9" HPA008477 Enhanced Approved Cytosol "Intracellular and membrane" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 83: Testis - Spermatogenesis" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Cytosol "HPA008477: AB_1079697" "unprognostic (4.35e-2)" "unprognostic (3.46e-2)" "unprognostic (7.06e-2)" "unprognostic (4.28e-3)" "unprognostic (1.19e-3)" "unprognostic (7.02e-2)" "unprognostic (1.22e-1)" "unprognostic (2.61e-2)" "unprognostic (2.33e-1)" "unprognostic (5.21e-2)" "unprognostic (8.83e-3)" "unprognostic (1.52e-3)" "unprognostic (2.97e-2)" "unprognostic (1.14e-2)" "unprognostic (5.07e-2)" "unprognostic (7.79e-2)" "unprognostic (2.99e-1)" 0.1 0.0 0.1 0.5 0.1 7.8 1.3 0.0 0.1 1.6 0.0 0.7 0.5 0.2 0.0 1.5 2.7 1.8 0.0 0.0 0.1 0.1 0.1 2.5 1.2 0.1 0.0 0.1 2.0 1.5 0.1 0.0 0.1 3.8 0.5 0.0 20.5 0.3 0.0 0.9 0.8 0.1 0.0 1.7 0.8 84.6 0.1 1.1 0.0 0.0 1.2 0.4 1.4 0.1 11.3 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 25.0 0.0 0.1 0.8 0.0 1.0 0.0 0.0 0.0 0.0 0.0 28.5 71.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 34.3 0.0 0.0 0.0 0.0 13.8 0.0 11.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.9 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 104.8 0.0 0.0 0.0 16.1 3.5 33.0 3.1 2.6 4.8 1.2 1.5 2.6 0.9 0.8 2.2 3.2 0.3 1.8 0.5 2.2 1.0 2.0 0.1 0.1 0.0 0.1 0.0 0.1 0.1 0.0 0.1 0.0 0.1 0.1 0.2 0.0 0.0 0.0 4.6 1.1 37.9 9.4 13.1 0.0 6.1 8.4 84.1 0.0 2.7 0.0 0.0 0.3 2.1 1.4 0.0 1.1 111.0 0.3 2.6 1.6 0.0 9.7 0.0 0.4 9.0 0.7 0.0 0.4 0.0 0.4 0.0 0.0 11.1 0.0 0.0 1.5 4.1 0.6 0.7 349.7 6.5 5.7 0.0 0.0 1.1 0.0 4.1 0.0 0.1 0.7 0.6 3.8 20.4 32.7 0.1 0.1 0.5 0.0 46.0 0.0 1.0 453.2 270.2 2.8 0.6 0.1 3.4 0.0 2.4 14.5 PRSS22 "BSSP-4, hBSSP-4, SP001LA" ENSG00000005001 "Serine protease 22" Q9GZN4 16 2852730-2858170 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 79.6;salivary gland: 26.9" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 221.0;Club cells: 343.9;Ionocytes: 207.5;Pancreatic endocrine cells: 380.6;Urothelial cells: 479.5" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "CAPAN-2: 17.3;MCF7: 14.6;RT4: 10.4;SK-BR-3: 22.9" "Region enhanced" "Detected in some" "cerebral cortex: 2.6" "Low region specificity" "Detected in all" HPA049161 Approved Approved Nucleoplasm "Secreted in other tissues" NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Nucleoplasm "HPA049161: AB_2680660" "unprognostic (1.45e-1)" "unprognostic (9.80e-2)" "unprognostic (3.50e-2)" "unprognostic (4.48e-1)" "unprognostic (2.29e-4)" "unprognostic (2.58e-1)" "unprognostic (4.42e-2)" "unprognostic (1.52e-2)" "unprognostic (5.06e-1)" "unprognostic (7.52e-2)" "unprognostic (3.74e-3)" "unprognostic (4.12e-1)" "unprognostic (2.32e-4)" "unprognostic (1.04e-2)" "unprognostic (1.58e-1)" "unprognostic (1.62e-1)" "unprognostic (2.75e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.1 0.0 23.4 0.0 0.5 0.3 0.7 0.4 79.6 1.3 0.8 0.0 0.0 0.0 16.7 0.5 2.9 0.0 0.0 0.0 0.0 5.8 1.5 2.4 1.1 0.0 6.0 0.5 0.0 26.9 0.3 0.0 3.2 0.2 0.0 0.0 0.0 5.4 0.0 0.0 0.0 1.3 0.0 2.2 2.5 23.2 0.0 1.1 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 1.3 17.3 0.0 0.0 0.0 0.0 1.8 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.6 0.1 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 10.4 0.0 0.0 0.0 22.9 0.0 0.0 2.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 3.2 4.2 0.0 0.2 23.2 221.0 128.8 28.5 0.0 42.8 23.7 0.3 38.6 343.9 16.5 0.0 36.7 1.9 18.5 1.9 113.1 0.0 28.4 4.6 1.8 3.6 0.0 0.0 98.3 37.1 1.3 52.5 56.6 0.0 0.0 0.0 0.1 2.3 0.0 0.0 7.5 207.5 0.0 1.4 0.0 0.0 0.9 7.2 0.0 1.0 0.0 0.0 0.0 0.0 380.6 32.3 0.0 0.3 75.4 0.6 0.2 108.0 0.0 0.0 0.0 13.7 0.1 0.2 22.7 27.6 10.5 2.7 0.0 6.9 479.5 PRSS23 "SIG13, SPUVE" ENSG00000150687 "Serine protease 23" O95084 11 86791059-86952910 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "cervix: 249.1" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 367.1;Endothelial cells: 502.1;Granulosa cells: 347.3;Hepatic stellate cells: 591.8;Theca cells: 445.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "gdT-cell: 104.6" "Group enriched" "Detected in many" 25 "NK-cells: 34.2;T-cells: 104.6" "Cell line enhanced" "Detected in many" "GAMG: 1093.7;hTERT-RPE1: 1296.9;TIME: 1138.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030591 Uncertain "Secreted to blood" NA NA 440000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "HPA030591: AB_10602067" "unprognostic (2.68e-2)" "unprognostic (1.20e-2)" "unprognostic (1.90e-1)" "unprognostic (2.04e-1)" "unprognostic (2.40e-3)" "prognostic unfavorable (2.12e-4)" "unprognostic (1.89e-2)" "unprognostic (4.30e-2)" "unprognostic (2.08e-1)" "unprognostic (2.09e-1)" "prognostic unfavorable (5.56e-4)" "unprognostic (5.35e-2)" "prognostic unfavorable (3.06e-4)" "unprognostic (5.13e-3)" "unprognostic (9.44e-2)" "unprognostic (1.99e-3)" "unprognostic (8.01e-2)" 55.0 21.4 7.8 35.3 7.8 2.1 43.2 7.1 8.7 249.1 12.9 103.6 19.2 103.4 13.4 22.1 24.9 83.8 28.3 7.9 8.0 42.4 15.0 63.3 21.8 14.0 13.9 26.8 29.8 36.0 16.4 61.7 8.8 61.3 50.3 2.7 52.4 128.2 79.6 19.4 29.0 115.5 7.1 18.0 54.2 31.8 14.1 17.5 40.9 18.7 10.2 99.6 79.1 7.4 62.7 153.3 161.1 1.0 70.4 172.3 0.7 269.0 244.4 293.2 232.6 368.1 484.7 0.2 208.2 414.7 1093.7 126.2 2.6 205.0 70.9 0.7 13.0 21.1 74.7 1.4 36.3 0.1 0.9 137.4 26.8 143.2 162.1 1296.9 604.8 0.9 1.3 0.3 223.4 87.7 0.2 0.3 9.8 211.7 16.8 0.0 0.0 0.7 111.5 82.3 1.5 1.0 59.9 4.5 18.7 397.6 6.0 0.6 1138.2 174.0 2.3 351.7 154.5 1.3 1.3 0.8 124.2 0.5 176.3 0.2 0.2 0.1 104.6 0.1 0.2 0.2 17.8 60.0 0.2 0.0 4.7 50.4 1.6 34.2 2.7 0.2 0.0 39.9 7.8 7.8 7.1 8.7 7.9 8.0 14.0 13.9 8.8 7.1 14.1 7.4 95.8 28.9 14.5 14.0 3.2 15.4 96.2 367.1 2.8 1.6 44.7 78.0 4.3 37.1 231.3 53.3 2.1 18.4 53.4 154.8 7.9 162.6 3.1 10.3 130.3 502.1 13.8 20.4 26.3 83.5 15.7 117.1 22.4 7.0 2.5 347.3 591.8 5.2 5.0 0.0 16.5 30.6 85.5 36.6 18.2 6.6 14.3 5.4 72.9 39.4 1.5 0.8 180.2 11.6 2.3 257.7 80.1 7.5 5.8 100.1 5.2 5.7 90.1 0.9 39.5 14.4 105.9 3.0 7.3 1.7 9.8 4.5 24.0 445.1 11.1 60.2 PRSS27 "CAPH2, MPN" ENSG00000172382 "Serine protease 27" Q9BQR3 16 2712419-2720551 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "cervix: 83.5;esophagus: 388.6;vagina: 134.2" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 9.6;Horizontal cells: 11.8;Squamous epithelial cells: 9.6;Urothelial cells: 11.1" "Cancer enhanced" "Detected in many" "head and neck cancer: 5.4" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 6.1;SK-BR-3: 24.4;T-47d: 14.6;U-266/70: 5.2" "Not detected" "Not detected" "Low region specificity" "Detected in some" "CAB024920, HPA028848" Approved Approved Vesicles "Secreted to digestive system" NA NA 8700000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 61: Squamous epithelial cells - Keratinization" Vesicles "CAB024920: , HPA028848: " "unprognostic (2.10e-2)" "unprognostic (2.15e-1)" "unprognostic (3.46e-3)" "unprognostic (5.35e-2)" "unprognostic (5.25e-2)" "unprognostic (2.48e-2)" "unprognostic (2.56e-1)" "unprognostic (3.12e-1)" "unprognostic (4.66e-1)" "unprognostic (1.08e-1)" "unprognostic (3.79e-2)" "unprognostic (4.40e-3)" "unprognostic (4.03e-3)" "unprognostic (2.40e-1)" "unprognostic (2.26e-1)" "unprognostic (2.04e-2)" "unprognostic (1.28e-2)" 1.0 0.4 0.9 0.2 0.9 0.3 1.3 1.0 2.0 83.5 0.6 1.0 0.0 1.0 0.0 388.6 0.7 0.2 0.4 0.8 1.4 1.1 0.6 0.6 0.3 1.2 1.5 0.5 0.8 0.7 1.5 0.1 1.0 1.0 0.0 0.2 52.5 0.4 0.3 3.3 0.6 0.0 1.0 0.6 0.8 2.6 1.2 0.6 0.8 0.0 29.9 0.8 134.2 0.9 0.1 0.3 0.4 2.1 0.3 0.7 6.1 0.0 0.2 0.2 0.2 0.1 0.5 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.5 0.1 0.1 0.0 1.0 0.0 0.3 1.2 0.0 0.0 0.0 0.3 0.0 0.1 0.1 0.6 0.0 2.0 0.0 1.1 1.4 0.2 0.0 1.0 0.2 0.1 0.2 0.3 0.7 2.8 0.0 24.4 0.6 0.1 14.6 1.8 0.0 0.4 0.0 0.1 0.0 5.2 3.7 0.5 0.0 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.9 0.9 1.0 2.0 0.8 1.4 1.2 1.5 1.0 1.0 1.2 0.9 1.5 9.6 5.8 0.0 0.5 1.8 2.5 1.3 0.6 5.2 5.1 6.2 1.2 1.5 5.6 1.8 4.2 0.7 0.5 1.2 0.0 1.5 3.3 0.6 1.4 1.8 0.0 0.0 0.4 1.4 0.6 1.4 1.1 1.6 3.8 1.1 0.4 0.7 0.3 11.8 0.8 0.5 0.0 0.3 3.1 1.0 0.3 0.8 1.8 1.9 0.9 2.6 0.0 0.0 0.3 1.1 1.2 0.0 0.2 1.7 0.1 0.7 3.4 6.6 0.0 2.7 1.5 3.0 3.9 9.6 2.4 3.3 1.3 0.6 1.4 11.1 PRSS3 "PRSS4, TRY3, TRY4" ENSG00000010438 "Serine protease 3" P35030 9 33750679-33799231 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" Digestion "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 268 "pancreas: 31113.6" "Cell type enhanced" "Detected in many" "Distal enterocytes: 1022.9;Exocrine glandular cells: 2040.4;Pancreatic endocrine cells: 478.8;Paneth cells: 969.9;Proximal enterocytes: 1127.1" "Group enriched" "Detected in many" 7 "colorectal cancer: 72.8;pancreatic cancer: 104.4;stomach cancer: 43.8" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 104 "basophil: 158.7" "Lineage enriched" "Detected in many" 104 "granulocytes: 158.7" "Group enriched" "Detected in many" 5 "OE19: 316.6;PC-3: 852.5" "HPA062452, HPA063471" Supported Approved "Endoplasmic reticulum,Vesicles" "Secreted to digestive system" NA NA 700000000 "Cluster 38: Basophils - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" Vesicles "Endoplasmic reticulum" "HPA062452: AB_2684768, HPA063471: AB_2685017" "unprognostic (6.90e-2)" "unprognostic (2.26e-1)" "unprognostic (1.69e-2)" "prognostic unfavorable (4.30e-4)" "unprognostic (3.18e-1)" "unprognostic (1.64e-1)" "unprognostic (3.29e-2)" "unprognostic (5.89e-3)" "unprognostic (1.38e-1)" "unprognostic (2.06e-3)" "unprognostic (1.10e-2)" "unprognostic (8.94e-2)" "unprognostic (7.75e-4)" "unprognostic (5.46e-3)" "unprognostic (2.13e-1)" "unprognostic (8.79e-2)" "unprognostic (4.96e-1)" 3.8 4.6 23.5 7.2 29.3 0.6 1.7 25.8 35.4 30.8 16.9 87.0 92.6 0.4 0.0 116.2 0.3 22.8 6.3 28.2 25.6 3.7 12.4 0.6 0.7 25.0 24.5 12.9 31113.6 0.0 0.7 1.7 25.7 1.1 77.8 0.3 20.9 0.3 0.5 79.7 105.4 3.1 19.4 0.7 22.8 5.1 25.6 0.8 0.4 0.0 15.2 4.2 56.9 24.7 12.0 13.7 0.7 0.0 0.2 5.9 0.1 33.6 7.7 4.1 1.6 34.3 3.0 0.0 0.2 14.9 0.2 15.0 0.0 31.7 10.1 0.4 0.2 0.0 1.1 0.0 2.7 0.0 0.0 0.2 0.0 10.8 110.2 0.3 68.8 0.2 0.0 0.0 0.0 0.2 0.7 0.4 0.2 316.6 852.5 0.0 0.0 0.0 0.0 1.7 0.3 81.2 0.2 0.0 0.0 0.5 0.0 0.0 78.3 0.0 0.0 12.8 0.0 0.0 0.0 0.1 18.1 0.0 0.1 158.7 0.0 0.0 0.2 1.5 1.2 0.0 0.2 0.4 0.5 0.0 0.0 0.0 0.0 0.4 1.5 0.0 0.0 0.3 23.5 29.3 25.8 35.4 28.2 25.6 25.0 24.5 25.7 19.4 25.6 24.7 0.1 0.0 0.0 0.7 1.9 57.1 0.6 1.3 0.0 0.2 0.1 2.8 1.0 47.1 1.2 1.8 0.0 0.0 0.1 1022.9 3.9 43.2 31.4 0.0 0.0 3.2 192.6 0.0 32.8 2040.4 0.0 0.8 39.3 0.0 8.9 0.0 0.7 4.2 0.0 0.0 4.7 146.4 0.0 0.3 12.1 79.7 1.5 1.2 7.2 3.7 5.7 0.0 0.0 3.5 1.2 478.8 969.9 0.7 0.3 12.1 1127.1 14.7 0.1 0.2 0.0 0.0 1.7 0.5 0.9 1.1 134.1 0.1 2.1 0.0 329.0 56.2 PRSS33 EOS ENSG00000103355 "Serine protease 33" Q8NF86 16 2783953-2787948 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 5 "fallopian tube: 4.7" "Cell type enhanced" "Detected in some" "Collecting duct cells: 1.8;Melanocytes: 1.8" "Cancer enhanced" "Detected in many" "ovarian cancer: 8.0" "Not detected" "Not detected" "Immune cell enriched" "Detected in some" 65 "eosinophil: 1296.1" "Lineage enriched" "Detected in many" 391 "granulocytes: 1296.1" "Cell line enhanced" "Detected in some" "HMC-1: 2.7;hTERT-RPE1: 5.0;SK-MEL-30: 5.9;U-2 OS: 2.0" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Secreted to blood" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 48: Smooth muscle cells - ECM organization" "unprognostic (4.78e-1)" "unprognostic (1.22e-1)" "unprognostic (8.99e-2)" "unprognostic (3.38e-2)" "unprognostic (3.10e-1)" "unprognostic (2.86e-2)" "unprognostic (1.16e-1)" "unprognostic (4.13e-2)" "unprognostic (1.16e-1)" "unprognostic (1.42e-2)" "unprognostic (2.28e-1)" "unprognostic (1.91e-1)" "unprognostic (2.70e-2)" 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.4 0.0 0.0 0.0 4.7 0.4 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.9 0.0 0.0 0.0 0.9 0.4 0.0 0.4 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 5.9 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 20.0 0.4 1296.1 0.2 0.4 0.2 0.1 0.1 0.0 0.2 0.2 0.1 0.3 2.1 3.3 0.3 0.1 0.1 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.2 0.0 0.0 1.8 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.3 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 PRSS35 "C6orf158, dJ223E3.1, MGC46520" ENSG00000146250 "Serine protease 35" Q8N3Z0 6 83512534-83525704 "Enzymes, Predicted secreted proteins" "Serine protease homolog" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "retina: 50.5" "Cell type enriched" "Detected in some" 36 "Muller glia cells: 410.9" "Group enriched" "Detected in some" 4 "glioma: 2.8;testis cancer: 4.7" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 9 "MAIT T-cell: 19.5" "Lineage enriched" "Detected in single" 195 "T-cells: 19.5" "Cell line enhanced" "Detected in some" "BJ hTERT+: 10.4;CACO-2: 86.3;HAP1: 12.8;RPTEC TERT1: 24.6;SuSa: 17.9" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "amygdala: 2.9;cerebellum: 3.6;cerebral cortex: 5.8;hippocampal formation: 5.3;olfactory bulb: 2.7" "HPA038787, HPA038788" Uncertain "Secreted in female reproductive system" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 39: CACO-2 - Unknown function" "Cluster 5: Muller glia cells - Visual perception" "HPA038787: AB_10675951, HPA038788: AB_2676208" "unprognostic (6.17e-2)" "unprognostic (8.75e-2)" "unprognostic (1.19e-2)" "unprognostic (2.63e-2)" "unprognostic (1.16e-1)" "unprognostic (4.03e-2)" "unprognostic (3.70e-4)" "unprognostic (6.08e-2)" "unprognostic (1.18e-3)" "unprognostic (2.33e-2)" "unprognostic (7.01e-2)" "unprognostic (9.07e-2)" "unprognostic (3.88e-6)" "unprognostic (7.15e-3)" "unprognostic (5.81e-2)" "unprognostic (2.82e-2)" "unprognostic (3.54e-4)" 1.3 2.4 2.9 0.1 3.8 0.0 0.3 1.7 6.8 2.9 1.5 0.1 0.3 1.3 1.1 0.3 1.4 4.2 4.4 3.2 2.1 3.1 0.4 1.3 0.7 1.8 1.9 10.2 0.3 0.3 1.1 3.6 1.8 1.1 0.3 50.5 0.3 0.4 0.1 0.2 0.1 1.5 1.8 0.7 0.3 3.1 2.6 0.1 0.4 0.1 0.1 1.3 0.5 2.2 0.0 0.5 1.9 0.0 0.1 0.0 0.0 0.3 10.4 1.0 2.0 86.3 0.0 0.0 0.1 0.4 0.0 0.0 12.8 0.0 0.6 0.0 0.5 0.0 0.0 0.0 0.2 0.0 0.0 3.1 0.0 1.2 0.0 0.2 0.1 0.0 0.0 0.0 0.2 0.1 0.0 0.1 1.6 0.4 8.2 0.0 0.0 0.0 24.6 0.0 0.0 1.0 0.0 0.0 0.0 17.9 0.0 0.0 0.0 0.3 0.8 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 1.2 0.0 19.5 0.0 0.3 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.9 3.8 1.7 6.8 3.2 2.1 1.8 1.9 1.8 1.8 2.6 2.2 0.3 3.2 0.5 8.1 0.0 0.0 0.0 0.0 0.0 3.2 0.0 0.1 1.5 0.0 0.0 1.8 0.0 0.3 0.0 0.1 9.8 0.1 0.1 0.0 0.3 0.8 1.8 0.0 0.2 0.0 0.0 4.4 0.0 0.0 0.0 0.9 0.0 0.3 0.4 6.7 0.2 0.0 0.0 0.0 0.0 0.2 1.2 0.1 0.0 1.0 0.0 410.9 0.0 1.0 0.1 0.0 0.0 8.6 0.0 0.0 0.0 0.0 0.0 11.4 6.6 0.1 3.7 0.1 0.5 0.0 0.0 0.1 0.7 5.1 0.0 0.0 PRSS36 FLJ90661 ENSG00000178226 "Serine protease 36" Q5K4E3 16 31138926-31150083 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "pituitary gland: 2.6" "Cell type enhanced" "Detected in many" "Breast myoepithelial cells: 11.7;Distal enterocytes: 13.2;Hofbauer cells: 18.7;Paneth cells: 15.4;Proximal enterocytes: 46.9" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Immune cell enhanced" "Detected in some" "eosinophil: 2.0" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in single" "HeLa: 2.6" "Low region specificity" "Detected in all" "Not detected" "Not detected" HPA036079 Uncertain "Secreted to extracellular matrix" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 27: Brain & Skin - Unknown function" "Cluster 20: HeLa - Mitochondria" "Cluster 45: Enterocytes - Digestion" "HPA036079: AB_10602290" "unprognostic (3.74e-2)" "prognostic favorable (2.97e-7)" "unprognostic (1.43e-1)" "unprognostic (1.20e-2)" "unprognostic (4.26e-3)" "unprognostic (1.31e-5)" "unprognostic (4.18e-2)" "unprognostic (5.05e-2)" "unprognostic (2.65e-2)" "unprognostic (8.03e-2)" "unprognostic (2.08e-1)" "unprognostic (1.23e-1)" "unprognostic (1.32e-3)" "unprognostic (2.39e-1)" "unprognostic (9.86e-2)" "unprognostic (1.23e-1)" "unprognostic (3.13e-1)" 1.4 0.8 0.4 0.3 0.6 0.4 0.5 0.4 0.8 0.2 0.3 0.7 1.0 0.1 0.0 0.3 0.3 0.1 0.3 0.5 0.5 0.2 0.3 0.7 0.1 0.5 0.4 0.1 0.2 0.1 2.6 0.7 0.5 0.1 0.2 0.0 0.5 0.1 0.2 1.0 0.7 0.3 0.4 0.1 0.3 0.4 0.6 0.8 0.3 0.0 0.2 0.4 0.2 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.4 0.0 0.2 0.1 0.1 0.4 0.0 0.0 0.0 0.0 0.2 0.8 2.6 0.4 0.0 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.2 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.3 2.0 0.1 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.1 1.0 0.1 0.0 0.2 0.0 0.0 0.4 0.6 0.4 0.8 0.5 0.5 0.5 0.4 0.5 0.4 0.6 0.5 0.3 0.0 1.1 0.7 0.2 1.9 2.6 8.9 1.8 0.5 5.9 11.7 1.1 2.8 3.5 0.0 0.0 0.8 1.2 13.2 0.0 1.7 1.7 0.9 0.6 0.6 0.0 0.4 0.6 2.8 1.2 1.3 1.1 0.9 0.0 0.5 3.3 3.3 18.7 0.0 0.8 4.1 2.0 3.2 3.8 0.9 2.8 4.2 0.0 0.0 5.4 0.6 4.1 0.0 0.1 1.8 15.4 2.6 0.0 1.7 46.9 1.9 1.2 0.0 0.0 0.4 0.4 0.6 4.4 1.5 2.6 0.5 0.5 1.1 3.9 1.9 PRSS37 ENSG00000165076 "Serine protease 37" A4D1T9 7 141836300-141841487 "Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins" Fertilization "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 55 "testis: 41.3" "Group enriched" "Detected in some" 138 "Early spermatids: 612.8;Late spermatids: 325.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA020541 Enhanced "Secreted in male reproductive system" NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 29: Early spermatids - Spermatogenesis" "HPA020541: AB_1853004" "unprognostic (4.70e-2)" "unprognostic (5.56e-2)" "unprognostic (2.69e-1)" "unprognostic (2.41e-1)" "unprognostic (3.21e-2)" "unprognostic (1.30e-1)" "unprognostic (2.74e-2)" "unprognostic (1.23e-2)" "unprognostic (8.30e-7)" "unprognostic (1.42e-1)" "unprognostic (2.06e-1)" "unprognostic (2.72e-2)" 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.1 0.3 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 41.3 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.7 0.2 0.2 0.1 0.3 0.2 0.1 0.2 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 612.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 325.7 2.1 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRSS38 MPN2 ENSG00000185888 "Serine protease 38" A1L453 1 227815693-227846470 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in single" 28 "testis: 4.2" "Group enriched" "Detected in some" 17 "Spermatocytes: 28.8;Spermatogonia: 18.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 12 "U-266/84: 1.2" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted in male reproductive system" NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 78: Testis - Spermatogenesis" "Cluster 16: U-266 - Nucleosome" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "unprognostic (9.54e-3)" "unprognostic (3.61e-3)" 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 1.1 0.0 0.0 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 1.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 28.8 18.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRSS41 TESSP1 ENSG00000215148 "Serine protease 41" Q7RTY9 16 2798470-2805304 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in single" "testis: 1.3" "Not detected" "Not detected" "Cancer enhanced" "Detected in some" "testis cancer: 1.8" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 105 "eosinophil: 10.5" "Lineage enriched" "Detected in single" 105 "granulocytes: 10.5" "Cell line enriched" "Detected in single" 10 "BEWO: 1.8" "Not detected" "Not detected" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 83: Testis - Spermatogenesis" "Cluster 28: BEWO - Transcription regulation" "unprognostic (1.58e-1)" "unprognostic (3.65e-1)" "unprognostic (3.04e-3)" "unprognostic (1.03e-1)" "unprognostic (1.71e-2)" "unprognostic (1.69e-1)" "unprognostic (1.98e-1)" "unprognostic (1.24e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 PRSS45P "PRSS45, TESPL, TESSP5" ENSG00000188086 "Serine protease 45, pseudogene" Q7RTY3 3 46742092-46750891 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in many" "epididymis: 6.4;skeletal muscle: 10.4" "Not detected" "Not detected" "Low cancer specificity" "Detected in single" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" HPA060284 Uncertain NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 68: Epididymis - Unknown function" "HPA060284: AB_2684242" "unprognostic (4.55e-3)" "unprognostic (3.49e-2)" "unprognostic (1.07e-2)" "unprognostic (2.50e-1)" "unprognostic (6.07e-2)" "unprognostic (1.28e-2)" "unprognostic (1.06e-1)" "unprognostic (6.20e-2)" "unprognostic (1.54e-1)" "unprognostic (1.30e-1)" "unprognostic (3.83e-4)" "unprognostic (2.33e-2)" "unprognostic (6.60e-3)" "unprognostic (1.27e-2)" "unprognostic (1.57e-2)" "unprognostic (2.15e-1)" "unprognostic (5.97e-3)" 0.3 0.2 0.3 0.0 0.3 0.0 1.1 0.5 0.4 1.6 1.0 0.5 0.1 0.3 6.4 0.2 0.9 0.0 3.5 0.2 0.7 1.7 1.3 0.6 0.1 0.6 0.7 0.4 2.1 2.8 1.9 0.1 0.7 1.4 0.0 0.2 0.9 1.0 10.4 0.3 0.3 0.1 0.5 0.3 0.3 2.2 0.6 0.2 4.9 0.9 0.0 0.7 0.8 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.2 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.5 0.4 0.2 0.7 0.6 0.7 0.7 0.5 0.6 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRSS48 ESSPL ENSG00000189099 "Serine protease 48" Q7RTY5 4 151277171-151291453 "Enzymes, Predicted membrane proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enriched" "Detected in some" 5 "choroid plexus: 18.6" "Group enriched" "Detected in some" 4 "Excitatory neurons: 2.2;Oligodendrocyte precursor cells: 8.5;Oligodendrocytes: 3.7;Sertoli cells: 6.6;Spermatocytes: 3.1;Spermatogonia: 4.0" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA053801 Uncertain "Secreted - unknown location" NA NA "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "HPA053801: AB_2682267" "unprognostic (9.68e-2)" "unprognostic (1.35e-2)" "unprognostic (2.15e-1)" "unprognostic (2.18e-2)" "unprognostic (3.76e-2)" "unprognostic (4.10e-2)" 0.0 0.0 1.6 0.0 2.2 0.0 0.0 2.8 1.6 0.0 18.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.8 0.0 0.0 0.0 0.0 2.9 1.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.8 0.0 0.0 0.7 1.9 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 2.2 2.8 1.6 1.0 2.8 2.9 1.0 3.4 0.8 1.9 2.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.0 2.2 0.0 0.0 0.2 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 8.5 3.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 6.6 0.1 0.0 3.1 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRSS50 "CT20, TSP50" ENSG00000283706 "Serine protease 50" Q9UI38 3 46712117-46717869 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "pituitary gland: 17.2;testis: 52.0;thyroid gland: 16.5" "Group enriched" "Detected in some" 8 "Spermatocytes: 359.2;Spermatogonia: 303.6" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "HMC-1: 1.4" HPA040768 Supported "Intracellular and membrane" NA NA "Cluster 43: Testis - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "HPA040768: AB_2677126" 0.5 1.2 0.9 0.0 0.9 0.1 1.9 2.3 1.5 4.5 0.7 1.6 0.0 1.5 2.9 0.4 2.3 0.1 4.1 1.1 1.2 5.4 2.7 0.7 0.0 1.2 0.9 2.2 4.6 1.4 17.2 0.1 1.0 4.5 0.0 0.2 1.9 2.1 1.2 0.4 0.5 0.2 1.2 0.3 1.0 52.0 1.1 0.2 16.5 0.0 0.0 1.7 2.1 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.1 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.9 2.3 1.5 1.1 1.2 1.2 0.9 1.0 1.2 1.1 0.9 0.0 0.0 0.0 1.6 0.0 0.1 0.5 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 18.9 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 26.1 3.1 0.2 0.0 1.0 0.0 0.6 0.0 0.5 0.0 0.0 0.0 1.5 0.0 0.2 0.0 0.0 0.1 0.1 39.5 0.2 0.0 359.2 303.6 0.0 0.0 0.0 0.0 0.0 0.0 0.5 PRSS51 ENSG00000253649 "Serine protease 51" A0A1B0GVH4 8 10482878-10547585 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "Evidence at transcript level" "Tissue enriched" "Detected in some" 17 "brain: 22.6" "Group enriched" "Detected in some" 10 "Early spermatids: 3.2;Late spermatids: 3.2" "Low cancer specificity" "Detected in many" "Region enriched" "Detected in some" 12 "cerebellum: 22.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "U-2 OS: 1.4" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Secreted in brain" NA NA "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 34: Spermatids - Unknown function" "unprognostic (2.52e-1)" "unprognostic (3.00e-1)" "unprognostic (3.10e-1)" "unprognostic (1.90e-1)" "unprognostic (1.06e-1)" "unprognostic (2.22e-2)" "unprognostic (2.72e-1)" "unprognostic (7.48e-2)" "unprognostic (1.64e-1)" "unprognostic (7.94e-2)" "unprognostic (1.02e-1)" "unprognostic (6.33e-3)" "unprognostic (2.71e-3)" "unprognostic (7.47e-2)" "unprognostic (3.42e-1)" "unprognostic (1.08e-1)" "unprognostic (1.06e-1)" 0.0 0.1 0.3 0.1 0.5 0.2 1.1 22.6 1.9 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.2 0.6 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.5 0.1 0.0 0.7 0.1 0.0 0.0 0.2 0.2 0.0 0.0 0.3 0.1 1.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.5 22.6 1.9 0.4 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRSS53 POL3S ENSG00000151006 "Serine protease 53" Q2L4Q9 16 31083425-31089628 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 3.2;liver: 9.9" "Cell type enhanced" "Detected in some" "Excitatory neurons: 6.3;Inhibitory neurons: 4.3;Oligodendrocytes: 4.4" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "SCLC-21H: 4.8;U-87 MG: 2.3" "Low region specificity" "Detected in many" "Not detected" "Not detected" "HPA034955, HPA034956" Uncertain "Secreted in other tissues" NA NA "Cluster 15: Liver - Metabolism" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA034955: AB_2674380, HPA034956: AB_10696365" "unprognostic (3.13e-1)" "unprognostic (4.15e-1)" "unprognostic (3.88e-3)" "unprognostic (1.62e-1)" "unprognostic (1.20e-1)" "unprognostic (1.63e-2)" "unprognostic (1.84e-1)" "unprognostic (2.63e-2)" "unprognostic (1.04e-2)" "unprognostic (2.87e-2)" "unprognostic (2.72e-2)" "unprognostic (1.63e-4)" "unprognostic (2.53e-12)" "unprognostic (1.02e-1)" "unprognostic (2.01e-1)" "unprognostic (1.37e-1)" "unprognostic (1.16e-1)" 0.2 0.1 1.7 0.4 1.9 0.0 0.2 1.9 3.2 0.5 1.5 0.4 0.3 0.3 0.1 0.3 0.1 0.3 0.2 1.8 1.9 0.6 9.9 0.4 0.4 1.8 1.8 0.3 0.6 0.0 0.8 0.1 1.8 0.9 0.1 0.1 0.4 0.2 0.1 2.8 0.4 0.4 1.7 0.5 0.5 0.0 1.8 0.1 0.4 0.0 0.0 0.4 0.5 2.2 0.3 0.4 0.1 0.3 0.0 0.5 0.8 0.4 0.8 0.5 0.0 0.1 0.2 0.1 0.5 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.7 0.8 0.0 0.4 0.3 1.0 0.0 0.4 0.1 0.9 0.2 1.1 0.4 0.0 1.0 1.0 0.0 0.0 0.0 0.0 4.8 0.3 0.4 0.0 0.4 0.0 0.5 0.2 0.3 0.8 0.5 1.6 0.1 0.7 0.2 0.1 2.3 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 1.9 1.9 3.2 1.8 1.9 1.8 1.8 1.8 1.7 1.8 2.2 0.2 0.0 0.0 1.6 0.2 0.4 0.2 0.2 0.0 0.4 0.1 0.1 0.5 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.1 0.3 0.3 0.0 0.4 6.3 0.2 0.2 0.2 1.1 0.3 0.0 0.3 0.4 0.7 0.1 0.0 4.3 0.1 0.0 0.0 0.4 0.2 1.8 0.4 0.0 0.0 0.0 0.1 0.0 0.5 4.4 0.4 0.0 1.2 0.2 0.0 0.7 0.0 0.0 0.4 0.0 0.3 0.2 0.1 0.1 0.5 1.4 0.0 1.0 0.1 0.1 0.3 PRSS54 "CT67, FLJ25339, KLKBL4" ENSG00000103023 "Serine protease 54" Q6PEW0 16 58279997-58295047 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Serine protease homolog" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in single" 110 "testis: 41.4" "Group enriched" "Detected in some" 34 "Early spermatids: 526.0;Late spermatids: 208.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in single" HPA041549 Enhanced "Secreted in male reproductive system" NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 29: Early spermatids - Spermatogenesis" "HPA041549: AB_10795640" "unprognostic (1.13e-1)" "unprognostic (3.24e-2)" "unprognostic (3.09e-2)" "unprognostic (3.08e-1)" "unprognostic (4.88e-2)" "unprognostic (1.23e-1)" 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 41.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 526.0 0.4 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 208.3 5.3 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 10.7 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRSS55 "CT153, T-SP1, UNQ9391" ENSG00000184647 "Serine protease 55" Q6UWB4 8 10525532-10554166 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 58 "testis: 27.7" "Group enriched" "Detected in some" 46 "Early spermatids: 260.4;Late spermatids: 85.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Intracellular and membrane" NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 23: Spermatids - Flagellum & Golgi organization" "unprognostic (3.64e-1)" "unprognostic (8.44e-3)" "unprognostic (6.10e-2)" "unprognostic (7.40e-2)" "unprognostic (6.23e-5)" "unprognostic (6.62e-2)" 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 27.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 3.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 260.4 0.0 0.0 0.1 0.0 0.0 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.7 0.0 0.0 0.0 0.0 85.4 1.5 0.3 0.0 0.0 0.0 0.0 0.0 3.0 0.6 0.1 0.0 1.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 3.3 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRSS56 ENSG00000237412 "Serine protease 56" P0CW18 2 232520388-232525716 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Disease variant, Microphthalmia" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 7 "brain: 3.0;retina: 5.3;skeletal muscle: 9.7" "Group enriched" "Detected in some" 10 "Early spermatids: 29.0;Muller glia cells: 45.8" "Group enriched" "Detected in many" 4 "cervical cancer: 1.2;colorectal cancer: 2.5;endometrial cancer: 1.4;melanoma: 2.1;urothelial cancer: 4.7" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 5 "Daudi: 1.0" "Group enriched" "Detected in some" 10 "basal ganglia: 1.8;olfactory bulb: 4.2" "Region enhanced" "Detected in many" "olfactory bulb: 14.9" NA NA "Cluster 54: Non-specific - Microtubule organization" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 5: Muller glia cells - Visual perception" "unprognostic (3.26e-1)" "unprognostic (1.98e-2)" "unprognostic (1.31e-1)" "unprognostic (3.73e-3)" "unprognostic (2.28e-1)" "unprognostic (7.15e-2)" "unprognostic (4.64e-2)" "unprognostic (1.20e-1)" 0.0 0.0 0.4 0.0 1.2 0.0 0.0 1.6 3.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 3.0 0.0 0.0 0.0 0.0 2.9 1.3 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 5.3 0.0 0.0 9.7 0.0 0.0 0.0 1.1 0.0 0.0 0.8 1.4 0.0 0.0 0.5 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 1.2 1.6 3.0 0.1 3.0 2.9 1.3 3.0 1.1 1.4 0.8 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 29.0 1.4 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.4 2.2 0.0 0.0 0.0 0.0 0.0 45.8 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.1 0.0 3.6 0.0 0.4 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRSS57 "PRSSL1, UNQ782" ENSG00000185198 "Serine protease 57" Q6UWY2 19 685546-695498 "Enzymes, Predicted secreted proteins" "Heparin-binding, Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 102 "bone marrow: 165.3" "Cell type enriched" "Detected in some" 9 "Erythroid cells: 77.8" "Cancer enriched" "Detected in single" 10 "pancreatic cancer: 2.2" "Not detected" "Not detected" "Immune cell enhanced" "Detected in some" "basophil: 5.9" "Low lineage specificity" "Detected in many" "Group enriched" "Detected in some" 13 "NB-4: 377.2;THP-1: 184.4" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted to blood" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 24: NB-4 - Immune response" "Cluster 12: Non-specific - Cell cycle regulation" "unprognostic (2.89e-1)" "unprognostic (1.43e-1)" "unprognostic (2.10e-1)" "unprognostic (3.99e-4)" "unprognostic (3.07e-1)" "unprognostic (1.33e-2)" "unprognostic (3.50e-2)" "unprognostic (4.04e-2)" "unprognostic (7.70e-2)" "unprognostic (3.80e-1)" "unprognostic (1.11e-1)" "unprognostic (3.46e-2)" "unprognostic (8.16e-2)" "unprognostic (2.56e-2)" 0.1 0.0 0.0 0.0 0.0 165.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.1 0.0 0.1 0.5 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 22.1 0.0 0.0 0.1 7.9 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 2.1 0.0 377.2 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 184.4 0.0 0.0 0.1 0.1 0.1 0.3 0.0 0.0 0.0 3.2 0.0 5.9 1.1 0.0 0.4 0.2 0.0 0.0 0.0 3.1 1.5 0.0 0.0 0.5 0.7 2.5 0.0 0.1 0.0 3.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 7.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 77.8 0.1 0.0 0.4 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.3 0.5 0.0 0.0 0.2 0.0 0.0 2.5 1.0 8.2 0.0 0.1 0.1 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.1 0.0 0.0 PRSS58 TRYX3 ENSG00000258223 "Serine protease 58" Q8IYP2 7 142252143-142258058 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in single" 180 "testis: 25.8" "Group enriched" "Detected in some" 129 "Early spermatids: 640.5;Late spermatids: 243.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted in male reproductive system" NA NA "Cluster 36: Testis - Spermatogenesis" "Cluster 29: Early spermatids - Spermatogenesis" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 25.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 640.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 243.0 3.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRSS8 ENSG00000052344 "Serine protease 8" Q16651 16 31131433-31135727 "Enzymes, Predicted membrane proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "salivary gland: 245.4" "Cell type enhanced" "Detected in many" "Distal enterocytes: 403.5;Extravillous trophoblasts: 648.4;Paneth cells: 262.6;Proximal enterocytes: 358.0;Syncytiotrophoblasts: 450.7" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in single" "cerebellum: 2.1" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 243.7;CACO-2: 165.9;CAPAN-2: 111.9;hTCEpi: 157.8;OE19: 79.6;SK-BR-3: 186.3" "Region enriched" "Detected in single" 8 "hippocampal formation: 1.4" "Low region specificity" "Detected in single" HPA030436 Uncertain "Secreted - unknown location" NA NA 4400000 "Cluster 29: Non-specific - Vesicular transport" "Cluster 28: BEWO - Transcription regulation" "Cluster 38: Extravillous trophoblasts - Unknown function" "HPA030436: AB_10602291" "unprognostic (1.88e-1)" "unprognostic (2.97e-1)" "unprognostic (9.34e-2)" "unprognostic (4.08e-1)" "unprognostic (6.83e-2)" "unprognostic (5.07e-3)" "unprognostic (5.78e-2)" "unprognostic (2.05e-1)" "unprognostic (2.26e-1)" "unprognostic (4.51e-2)" "unprognostic (8.74e-3)" "unprognostic (1.58e-1)" "prognostic favorable (2.05e-10)" "unprognostic (1.89e-2)" "unprognostic (1.20e-1)" "unprognostic (1.31e-1)" "unprognostic (3.63e-3)" 0.8 0.4 0.3 15.0 0.4 0.2 25.5 2.1 0.6 31.1 6.7 129.4 155.7 9.9 113.0 136.2 15.4 47.7 0.4 0.6 0.2 90.6 28.0 54.1 0.3 0.3 0.2 0.6 139.4 56.0 8.4 51.0 0.4 49.0 72.6 0.0 245.4 8.5 0.3 115.3 151.8 3.5 0.1 0.2 156.2 0.5 0.2 15.4 50.8 0.0 11.8 4.9 56.0 0.2 63.4 0.2 0.1 0.2 0.0 0.0 243.7 0.0 0.0 0.0 0.0 165.9 111.9 0.0 1.3 0.0 0.0 73.5 0.1 69.7 0.0 0.3 0.4 0.1 0.3 6.5 0.0 0.0 0.3 0.0 157.8 0.0 2.4 0.0 0.0 0.1 1.9 0.1 0.0 68.1 0.6 1.4 20.5 79.6 0.1 0.5 0.0 1.2 7.5 13.1 0.9 0.7 0.0 186.3 0.1 18.8 42.8 0.8 0.0 0.1 1.9 0.6 0.4 0.3 0.5 0.1 0.1 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 2.1 0.6 0.6 0.2 0.3 0.2 0.4 0.1 0.2 0.2 0.4 99.3 60.1 0.0 1.0 37.9 82.7 108.9 76.2 0.5 74.4 39.2 0.3 62.9 107.4 42.3 0.0 168.8 0.8 403.5 29.4 192.4 0.0 35.2 11.4 2.6 9.6 2.7 0.1 224.4 648.4 3.5 82.6 109.5 7.0 0.0 0.0 18.2 22.8 0.0 0.2 132.1 87.5 0.3 2.7 0.0 0.6 1.9 3.6 0.0 4.2 0.3 0.0 0.0 0.0 240.7 262.6 0.0 0.1 66.0 358.0 28.6 21.2 0.1 0.0 0.1 4.7 0.0 0.2 81.9 54.0 450.7 2.2 0.0 150.8 91.0 PRTN3 "ACPA, AGP7, C-ANCA, MBT, P29, PR-3" ENSG00000196415 "Proteinase 3" P24158 19 840999-848175 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 55 "bone marrow: 2098.1" "Cell type enriched" "Detected in some" 17 "Erythroid cells: 26.5" "Cancer enhanced" "Detected in single" "stomach cancer: 1.0" "Low region specificity" "Detected in single" "Immune cell enriched" "Detected in single" 8 "neutrophil: 2.0" "Lineage enriched" "Detected in single" 8 "granulocytes: 2.0" "Cell line enriched" "Detected in some" 6 "THP-1: 2054.4" "Not detected" "Not detected" "Not detected" "Not detected" "HPA005938, CAB017558" Enhanced Approved Vesicles,Cytosol "Secreted to blood" NA NA 390000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 43: THP-1 - Innate immune response" "Cluster 12: Non-specific - Cell cycle regulation" Cytosol Vesicles "CAB017558: AB_2172317, HPA005938: AB_1855764" "unprognostic (2.81e-2)" "unprognostic (2.10e-1)" "unprognostic (3.83e-3)" "unprognostic (4.20e-1)" "unprognostic (3.31e-2)" "unprognostic (3.34e-1)" "unprognostic (9.98e-3)" "unprognostic (3.67e-2)" "unprognostic (8.62e-6)" "unprognostic (5.31e-2)" "unprognostic (2.00e-1)" "unprognostic (5.14e-2)" 0.8 0.2 0.6 0.0 0.7 2098.1 0.4 0.2 1.3 0.0 0.2 0.1 0.0 0.3 0.0 0.0 0.1 0.0 1.6 0.6 0.4 0.3 2.8 11.7 0.4 0.3 0.4 0.1 0.1 0.2 1.3 0.6 0.4 0.3 0.0 0.0 1.6 0.0 0.3 1.3 0.0 0.0 0.2 38.2 0.1 0.2 0.6 7.1 0.4 0.0 0.0 0.0 0.1 0.4 1.2 0.6 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.4 0.3 0.0 0.1 0.0 0.0 5.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 343.6 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.3 2054.4 0.0 0.0 0.0 0.2 0.9 0.0 0.2 0.3 0.0 14.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 9.9 0.6 0.7 0.2 1.3 0.6 0.4 0.3 0.4 0.4 0.2 0.6 0.4 0.4 0.0 0.0 0.0 0.6 0.0 0.0 0.1 0.0 0.0 0.8 1.3 0.4 1.5 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.1 0.1 0.2 0.0 26.5 0.4 0.0 0.9 0.9 0.0 0.1 0.0 0.0 0.0 0.2 0.1 0.0 0.2 0.0 0.0 1.5 0.0 0.1 0.6 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.5 0.0 0.0 0.0 0.2 0.1 0.0 0.1 PSEN1 "AD3, FAD, PS1, S182" ENSG00000080815 "Presenilin 1" P49768 14 73136418-73223691 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Apoptosis, Cell adhesion, Notch signaling pathway" "Hydrolase, Protease" "Alzheimer disease, Amyloidosis, Cancer-related genes, Cardiomyopathy, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in all" 5 "Oligodendrocytes: 395.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB006844, HPA030760, HPA067496" Approved Supported "Nucleoplasm,Golgi apparatus,Cell Junctions" Yes No "Cluster 31: Non-specific - Inflammatory response" "Cluster 45: Intestine - Brush border" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Golgi apparatus" "Nucleoplasm, Cell Junctions" "CAB006844: , HPA030760: AB_10696211, HPA067496: AB_2685853" "unprognostic (1.67e-1)" "unprognostic (4.79e-2)" "unprognostic (7.39e-2)" "unprognostic (8.68e-3)" "unprognostic (3.84e-1)" "unprognostic (5.48e-3)" "prognostic unfavorable (1.99e-5)" "unprognostic (1.65e-1)" "unprognostic (8.99e-2)" "unprognostic (8.45e-2)" "unprognostic (1.76e-3)" "unprognostic (2.74e-1)" "prognostic favorable (1.52e-8)" "unprognostic (2.29e-1)" "unprognostic (2.32e-1)" "unprognostic (7.12e-3)" "unprognostic (1.85e-1)" 25.1 22.6 44.3 26.5 80.7 39.6 28.2 62.4 56.0 28.1 48.9 49.5 50.2 25.3 26.9 35.2 22.9 31.7 18.0 47.4 51.6 35.5 31.9 32.1 22.4 73.0 63.8 22.0 22.9 35.1 11.6 43.1 71.5 24.3 46.3 23.4 22.9 23.4 18.4 38.2 49.0 27.1 55.7 22.6 31.0 32.5 60.8 26.2 36.9 23.3 30.7 35.0 19.2 119.1 37.1 55.9 50.6 20.0 68.9 49.9 46.7 52.5 60.1 52.6 66.7 69.9 88.9 23.7 34.1 50.5 43.0 94.9 43.2 40.1 57.3 54.6 26.7 27.1 35.1 34.4 63.8 27.7 50.7 50.4 71.9 44.3 54.4 48.5 43.2 26.2 31.0 46.6 50.0 72.8 21.0 35.7 22.0 64.5 40.4 26.4 42.7 30.2 73.7 76.5 28.1 38.3 57.4 53.0 47.1 45.4 66.3 60.7 45.7 53.1 43.5 44.1 25.3 30.3 47.9 23.7 44.9 32.8 33.3 126.8 94.5 96.3 23.1 106.0 22.6 23.1 22.3 19.0 83.4 31.8 20.7 20.1 129.3 42.8 125.0 43.6 37.0 70.3 44.3 80.7 62.4 56.0 47.4 51.6 73.0 63.8 71.5 55.7 60.8 119.1 22.2 28.9 30.5 35.9 25.8 28.6 24.6 24.7 12.0 17.1 25.0 17.7 12.5 15.7 30.2 23.9 39.6 27.1 30.7 79.1 5.9 27.1 22.9 26.3 26.4 22.3 16.2 12.0 38.9 26.7 29.2 23.7 32.1 47.4 18.3 29.6 15.7 24.6 30.5 13.5 40.2 39.5 24.4 50.5 40.8 12.9 16.4 52.3 16.0 39.4 51.8 13.8 14.4 48.7 395.8 38.2 58.8 15.4 23.6 38.8 76.2 13.0 29.0 28.0 26.3 20.0 19.0 40.2 14.4 20.4 33.0 49.9 21.6 18.6 41.3 51.5 PSEN2 "AD3L, AD4, PS2, STM2" ENSG00000143801 "Presenilin 2" P49810 1 226870184-226927726 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Notch signaling pathway" "Hydrolase, Protease" "Alzheimer disease, Amyloidosis, Cardiomyopathy, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Ionocytes: 36.7;Syncytiotrophoblasts: 45.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 50: Non-specific - Ribosome" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 10: Non-specific - Unknown function" "unprognostic (3.40e-2)" "unprognostic (4.73e-3)" "unprognostic (2.94e-1)" "unprognostic (3.86e-2)" "unprognostic (6.54e-2)" "unprognostic (1.64e-3)" "unprognostic (4.72e-2)" "unprognostic (1.31e-1)" "unprognostic (9.98e-2)" "unprognostic (2.73e-2)" "unprognostic (8.25e-3)" "unprognostic (8.53e-3)" "unprognostic (8.45e-2)" "unprognostic (1.17e-1)" "unprognostic (8.36e-2)" "unprognostic (1.68e-1)" "unprognostic (1.06e-1)" 11.2 19.8 9.7 7.5 9.8 1.6 10.6 12.5 10.7 9.7 10.7 15.2 10.5 15.9 9.0 10.3 13.4 8.3 14.0 9.4 10.6 13.5 12.6 11.5 8.0 9.8 10.9 12.8 45.5 18.1 17.1 9.0 10.8 14.9 8.1 7.4 13.0 13.6 26.5 10.1 13.8 10.4 8.5 15.6 11.5 13.5 10.7 3.3 9.5 16.7 5.0 13.5 9.7 9.7 14.1 24.5 7.2 21.9 10.0 3.5 10.2 12.4 26.5 16.9 12.9 13.8 21.5 1.0 17.0 16.8 10.5 7.9 12.1 11.9 6.7 13.6 20.7 8.7 10.5 12.0 15.4 7.5 15.7 9.1 13.9 18.9 10.4 11.2 6.9 0.7 18.1 6.4 10.0 14.7 0.4 8.2 20.5 22.0 16.0 0.4 22.6 26.4 15.9 13.4 11.3 18.3 9.7 30.6 51.6 18.4 26.5 13.1 8.5 11.2 8.9 9.9 15.2 25.6 45.0 0.9 21.5 2.5 15.7 37.4 8.7 18.4 4.5 9.7 5.1 7.4 1.5 4.6 11.4 3.1 0.7 2.0 1.6 20.0 30.2 0.8 2.4 5.2 9.7 9.8 12.5 10.7 9.4 10.6 9.8 10.9 10.8 8.5 10.7 9.7 11.0 16.0 10.8 2.6 3.9 1.7 4.5 4.0 1.8 6.2 6.6 4.1 12.9 15.7 4.7 5.5 0.0 15.9 1.3 5.9 1.9 13.0 2.5 4.5 3.0 10.0 6.0 6.1 4.2 18.0 4.1 5.9 7.7 5.2 14.5 10.1 19.2 8.4 17.2 16.8 4.5 5.1 36.7 7.2 6.5 1.3 7.2 8.2 33.8 5.6 18.9 21.2 2.1 2.5 1.5 15.2 7.8 13.2 9.9 5.3 13.8 7.2 4.9 5.8 6.6 9.4 10.6 1.5 6.1 3.8 1.8 45.8 2.9 6.6 4.3 4.6 PSMA1 "HC2, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915, NU, PROS30" ENSG00000129084 "Proteasome 20S subunit alpha 1" P25786 11 14504874-14643635 "Enzymes, Predicted intracellular proteins" Immunity "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Syncytiotrophoblasts: 627.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033765, HPA037646, HPA043891, CAB079995" Supported Supported "Nucleoplasm,Nuclear bodies,Centrosome" NA NA 20000000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 8: Non-specific - Mitochondria" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 47: Cytotrophoblasts - Unknown function" Nucleoplasm "Nuclear bodies, Centrosome" "CAB033765: AB_2253026, CAB079995: , HPA037646: AB_10670386, HPA043891: AB_2678718" "unprognostic (1.72e-2)" "unprognostic (4.97e-2)" "unprognostic (7.33e-2)" "unprognostic (4.74e-2)" "unprognostic (7.52e-2)" "unprognostic (6.66e-3)" "prognostic unfavorable (3.79e-5)" "unprognostic (3.28e-3)" "unprognostic (7.44e-2)" "unprognostic (3.43e-3)" "unprognostic (8.27e-3)" "unprognostic (8.77e-2)" "prognostic unfavorable (4.03e-11)" "unprognostic (1.93e-1)" "unprognostic (1.69e-1)" "unprognostic (4.66e-2)" "unprognostic (1.23e-2)" 87.2 85.5 55.1 94.9 57.8 135.8 96.2 55.4 68.2 76.8 58.7 92.5 96.4 80.7 108.0 94.7 79.4 79.6 140.5 59.4 64.4 98.4 139.2 77.5 114.9 55.8 56.6 79.4 54.6 78.5 50.4 113.0 58.8 81.7 101.9 63.2 74.4 85.8 168.7 80.5 86.1 96.1 56.6 75.6 75.7 56.2 60.2 122.2 88.4 152.6 109.9 111.2 56.0 58.6 408.8 279.8 227.8 275.7 223.7 225.5 193.3 232.9 305.2 348.3 283.9 244.2 500.1 349.5 262.1 248.6 315.4 303.1 259.3 290.1 328.3 344.0 389.6 220.4 190.5 326.1 291.0 355.3 277.5 217.8 171.6 188.9 390.7 252.7 347.0 271.6 398.9 283.4 315.2 277.8 334.0 319.5 191.6 340.5 414.1 223.3 336.1 217.5 313.0 304.7 188.2 119.3 246.6 273.9 229.0 233.8 164.4 222.9 272.0 226.2 222.9 402.7 295.4 123.3 366.1 319.9 334.8 291.1 296.6 115.5 191.2 47.5 97.7 139.8 128.0 104.1 110.8 109.7 243.3 95.3 98.5 94.4 36.3 145.1 137.5 138.7 154.9 235.8 55.1 57.8 55.4 68.2 59.4 64.4 55.8 56.6 58.8 56.6 60.2 58.6 119.0 83.3 90.2 64.3 101.7 142.9 231.2 365.7 76.2 50.3 105.7 125.9 0.0 82.9 176.1 88.3 18.8 469.5 135.3 49.2 256.3 228.5 75.5 84.0 94.0 135.5 40.1 163.9 56.8 233.1 370.6 128.5 66.8 79.8 78.2 134.7 95.3 127.9 292.9 57.2 66.3 63.6 231.9 161.8 170.5 36.3 116.5 153.6 144.1 122.7 263.7 111.6 168.9 64.8 35.3 223.2 88.6 127.5 112.1 209.1 135.0 257.1 115.1 54.8 85.5 99.2 129.8 174.9 80.1 114.3 151.9 627.3 130.7 137.2 97.1 248.1 PSMA2 "HC3, MU, PMSA2" ENSG00000106588 "Proteasome 20S subunit alpha 2" P25787 7 42916828-42932185 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "monocytes: 439.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008188 Uncertain NA NA 61000000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 3: Monocytes - Immune response regulation" "HPA008188: AB_1855819" "unprognostic (9.40e-3)" "unprognostic (2.08e-2)" "unprognostic (8.21e-2)" "unprognostic (2.23e-2)" "unprognostic (4.13e-2)" "unprognostic (1.90e-1)" "prognostic unfavorable (1.29e-4)" "unprognostic (2.01e-2)" "unprognostic (9.25e-2)" "prognostic favorable (6.73e-5)" "unprognostic (1.77e-1)" "unprognostic (3.42e-1)" "unprognostic (1.62e-3)" "unprognostic (1.79e-1)" "unprognostic (1.06e-1)" "unprognostic (6.38e-2)" "unprognostic (4.24e-2)" 100.7 113.4 53.7 89.0 54.1 120.2 100.1 55.7 82.8 71.2 56.4 90.9 104.3 75.6 83.1 110.0 70.5 49.4 119.2 52.5 56.6 117.0 319.5 85.9 101.4 55.6 54.5 66.4 91.0 71.0 63.8 78.9 55.5 91.1 86.8 42.2 76.0 58.2 227.5 86.9 96.7 67.3 58.6 94.1 104.8 56.1 55.4 137.5 67.4 120.1 108.8 92.4 77.0 62.8 202.8 212.5 243.4 296.4 128.1 142.1 181.1 174.7 202.8 274.9 292.3 316.5 322.2 371.5 301.7 155.5 431.6 273.3 254.3 242.4 314.2 270.3 202.3 189.8 279.1 337.1 137.3 325.8 197.7 131.7 172.7 211.7 125.7 196.1 265.1 226.0 389.8 219.4 223.5 235.9 295.0 634.9 482.4 331.3 259.9 282.1 235.5 364.3 268.2 271.6 196.8 199.1 189.5 429.9 200.9 328.3 312.4 375.6 189.9 161.0 295.3 174.5 348.6 282.6 470.3 611.1 276.0 406.0 468.9 278.5 185.4 351.9 133.9 193.4 156.9 195.4 163.3 157.9 199.8 175.2 146.0 155.2 93.1 160.7 210.0 225.0 240.8 363.3 53.7 54.1 55.7 82.8 52.5 56.6 55.6 54.5 55.5 58.6 55.4 62.8 92.2 89.8 100.5 11.1 100.6 0.1 89.3 0.2 41.5 32.4 125.2 121.4 0.0 123.0 66.8 95.6 22.9 293.3 141.3 130.3 170.2 348.6 23.9 42.3 41.5 93.2 154.9 126.9 15.3 380.0 300.1 67.2 23.9 37.6 166.0 27.5 122.8 204.8 193.5 28.6 16.0 199.8 0.0 173.5 0.3 19.1 79.2 94.1 0.0 12.2 439.1 85.3 153.5 17.1 27.9 314.5 166.9 84.7 72.6 97.8 332.7 301.5 58.3 46.6 131.5 55.3 74.4 125.8 115.6 44.3 0.0 279.1 81.8 39.1 252.8 98.2 PSMA3 HC8 ENSG00000100567 "Proteasome 20S subunit alpha 3" P25788 14 58244843-58272012 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000905 Approved NA NA 9700000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 8: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 10: Non-specific - Unknown function" "HPA000905: AB_1079702" "unprognostic (3.60e-1)" "unprognostic (4.81e-3)" "unprognostic (1.17e-1)" "unprognostic (2.19e-2)" "unprognostic (4.91e-1)" "unprognostic (5.79e-2)" "unprognostic (1.97e-3)" "unprognostic (1.27e-1)" "unprognostic (7.92e-2)" "unprognostic (7.36e-3)" "unprognostic (1.65e-2)" "unprognostic (7.57e-2)" "unprognostic (1.83e-3)" "unprognostic (2.33e-2)" "unprognostic (6.47e-2)" "prognostic favorable (2.91e-4)" "unprognostic (2.16e-1)" 74.1 88.6 50.0 84.8 52.6 82.8 82.1 54.9 61.8 59.6 54.2 76.7 81.3 55.4 127.6 75.8 57.9 60.7 99.9 51.2 55.2 94.3 162.2 69.0 104.1 53.2 52.3 40.4 55.4 72.9 46.6 90.8 53.3 60.9 82.9 48.3 54.7 76.3 170.6 53.1 74.3 78.6 55.8 66.6 61.0 41.3 51.9 108.6 74.9 130.4 96.9 102.5 48.6 56.6 359.2 214.3 215.1 179.2 166.4 154.3 277.8 187.2 209.3 257.4 256.8 317.8 294.2 304.1 330.9 171.3 202.4 243.9 249.2 200.9 299.7 262.3 148.9 208.5 150.9 360.8 314.2 340.4 170.0 132.8 142.2 179.2 169.1 151.7 307.2 242.0 201.3 174.6 209.3 400.4 299.7 314.4 144.9 286.8 328.3 249.3 279.6 222.7 377.5 339.7 202.9 100.3 167.5 261.8 189.5 201.6 273.3 244.9 198.3 148.4 287.1 167.6 249.4 68.4 137.3 314.1 215.7 260.2 184.1 95.3 78.9 52.0 71.2 98.9 92.2 85.8 87.1 86.0 91.8 61.9 69.5 80.8 48.2 94.1 85.6 122.4 112.6 95.5 50.0 52.6 54.9 61.8 51.2 55.2 53.2 52.3 53.3 55.8 51.9 56.6 132.9 118.6 119.2 21.9 93.7 118.7 169.6 418.7 71.2 43.5 69.2 77.6 117.0 71.4 195.7 88.3 35.5 387.5 104.5 83.3 166.3 241.3 24.7 127.6 95.6 137.7 64.4 60.6 27.6 231.1 269.2 108.5 59.1 109.1 95.7 412.6 66.4 145.4 184.0 42.1 29.1 103.8 250.3 59.2 77.5 27.4 109.3 89.4 108.5 26.2 206.0 87.3 84.5 32.6 33.6 192.9 89.0 106.1 118.4 167.5 108.9 297.5 157.4 68.6 98.6 83.7 279.6 109.3 66.9 89.8 106.0 403.5 99.3 104.9 108.4 171.6 PSMA4 "HC9, HsT17706" ENSG00000041357 "Proteasome 20S subunit alpha 4" P25789 15 78540405-78552417 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004973, HPA055466, HPA060613" Supported Supported Nucleoplasm,Vesicles,Cytosol No No 13000000 "Cluster 7: Monocytes - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 32: U-937 - Innate immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Nucleoplasm, Cytosol" Vesicles "CAB004973: AB_425627, HPA055466: AB_2682824, HPA060613: AB_2684332" "unprognostic (1.80e-1)" "unprognostic (7.08e-3)" "unprognostic (1.31e-1)" "unprognostic (1.62e-1)" "unprognostic (4.71e-2)" "unprognostic (5.35e-2)" "unprognostic (6.26e-3)" "unprognostic (1.09e-1)" "unprognostic (3.28e-2)" "unprognostic (2.08e-3)" "unprognostic (2.75e-3)" "unprognostic (1.26e-1)" "prognostic unfavorable (6.74e-10)" "unprognostic (1.68e-1)" "unprognostic (1.56e-1)" "unprognostic (3.78e-3)" "unprognostic (6.32e-3)" 92.9 105.0 62.5 106.3 64.4 107.6 87.5 66.2 98.8 78.9 65.6 105.1 108.9 89.6 74.5 118.2 71.6 66.0 108.4 64.7 69.1 98.1 152.1 87.9 136.9 67.6 65.5 64.6 67.3 73.4 54.4 85.8 67.5 97.2 109.6 50.3 70.3 64.2 180.6 78.3 101.3 99.3 69.3 115.3 88.5 109.9 65.6 156.5 70.6 121.6 128.7 118.8 81.2 69.9 274.2 386.9 327.7 290.8 202.1 189.5 256.3 250.2 199.9 301.4 320.6 404.9 386.9 590.8 359.7 232.5 337.4 363.9 669.1 271.8 289.1 244.2 465.7 497.6 271.6 330.1 326.9 512.6 294.5 154.6 166.8 255.0 250.9 185.4 330.7 319.1 544.2 225.0 249.6 392.3 347.5 477.4 309.7 315.3 224.5 297.7 432.9 198.9 309.5 469.4 287.6 209.9 401.3 289.5 327.5 402.2 267.8 414.7 265.8 223.7 298.6 249.3 434.2 204.0 517.9 556.2 209.9 756.7 252.6 126.0 251.9 172.9 136.2 403.9 140.3 156.0 142.0 144.7 327.4 119.9 111.7 137.0 112.8 209.4 394.8 185.4 216.8 405.6 62.5 64.4 66.2 98.8 64.7 69.1 67.6 65.5 67.5 69.3 65.6 69.9 119.0 128.2 118.5 17.3 124.1 231.6 269.6 765.7 84.2 57.8 88.5 95.8 163.7 105.8 327.0 121.4 10.4 478.9 128.4 145.3 311.0 296.2 689.4 158.0 183.6 162.5 146.2 153.2 18.0 292.7 450.6 159.9 78.0 126.0 174.2 152.9 114.9 178.9 320.4 72.3 19.6 216.2 506.6 143.2 201.7 399.0 151.0 176.9 133.4 23.4 308.6 63.5 149.3 11.1 21.5 256.0 165.7 147.4 108.0 249.3 195.8 367.2 280.0 39.8 151.2 95.4 241.1 417.1 181.0 106.4 212.8 447.1 128.6 166.7 234.7 258.4 PSMA5 ZETA ENSG00000143106 "Proteasome 20S subunit alpha 5" P28066 1 109399042-109426448 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MOLT-4: 54.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028392, HPA028398, HPA028441" Approved Supported Cytosol NA NA 20000000 "Cluster 44: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 10: Non-specific - Unknown function" Cytosol "HPA028392: AB_10600115, HPA028398: AB_10602310, HPA028441: AB_10602003" "unprognostic (3.82e-2)" "unprognostic (3.09e-3)" "prognostic favorable (1.45e-5)" "unprognostic (1.57e-1)" "unprognostic (2.71e-1)" "unprognostic (1.52e-2)" "prognostic unfavorable (2.28e-4)" "unprognostic (5.95e-2)" "unprognostic (1.71e-2)" "unprognostic (1.13e-3)" "unprognostic (4.20e-3)" "unprognostic (3.05e-1)" "unprognostic (1.07e-3)" "unprognostic (3.99e-2)" "unprognostic (2.34e-1)" "unprognostic (8.81e-3)" "unprognostic (1.05e-1)" 3.5 4.7 5.1 4.3 6.2 3.8 6.8 4.0 7.7 5.8 2.7 7.4 7.5 5.5 8.6 6.8 9.1 5.4 7.7 6.8 6.7 10.9 20.2 5.9 12.7 5.0 4.7 5.2 3.2 5.9 1.4 6.9 4.5 5.4 8.5 4.8 5.0 6.2 6.1 6.2 6.7 6.5 4.1 4.8 5.2 3.5 5.3 6.4 10.2 5.1 9.3 6.1 0.9 6.6 10.1 11.7 6.2 5.7 17.6 16.9 12.6 4.9 29.8 23.2 17.9 15.0 5.5 28.1 7.8 21.2 4.2 5.7 13.8 13.7 16.1 10.7 13.1 13.4 7.7 12.4 14.0 15.2 5.3 8.5 12.3 12.7 14.3 6.2 15.0 8.2 17.1 6.5 12.4 18.6 54.4 10.3 5.7 7.0 16.5 4.4 16.9 7.4 19.0 11.5 7.3 5.2 10.5 16.2 8.9 5.0 5.9 14.1 11.7 4.6 4.6 7.9 10.3 3.6 11.6 19.7 20.0 26.0 7.4 11.0 4.3 3.1 7.7 6.3 8.4 5.7 9.0 8.3 5.9 4.7 9.7 9.7 1.4 7.2 6.1 4.2 11.4 7.0 5.1 6.2 4.0 7.7 6.8 6.7 5.0 4.7 4.5 4.1 5.3 6.6 68.9 41.7 56.8 9.4 77.4 63.6 73.5 231.0 38.1 32.6 59.5 75.7 89.5 75.8 120.9 42.3 6.2 227.0 114.5 82.1 140.8 164.9 82.0 157.6 74.1 71.6 56.3 85.0 21.7 183.0 181.4 60.4 74.9 81.9 82.4 77.7 51.4 117.4 166.9 13.5 18.4 144.1 168.9 57.8 73.6 23.4 67.7 86.3 58.7 15.0 184.8 50.2 114.4 13.0 20.2 191.6 103.5 62.1 113.1 122.2 138.0 205.6 172.4 31.7 46.0 56.1 182.6 120.3 89.1 70.4 65.9 241.2 106.1 121.4 135.3 104.2 PSMA6 "IOTA, MGC22756, MGC2333, MGC23846, p27K, PROS27" ENSG00000100902 "Proteasome 20S subunit alpha 6" P60900 14 35278633-35317493 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 156.3;Late spermatids: 474.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003049 Approved Supported Nucleoplasm NA NA 18000000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 23: Testis - Cell cycle regulation" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "HPA003049: AB_1079703" "unprognostic (9.68e-3)" "unprognostic (5.91e-2)" "unprognostic (1.90e-2)" "unprognostic (8.07e-2)" "unprognostic (3.42e-2)" "unprognostic (4.11e-3)" "unprognostic (7.48e-2)" "unprognostic (1.25e-1)" "unprognostic (1.16e-1)" "prognostic favorable (3.27e-4)" "unprognostic (1.29e-3)" "unprognostic (2.63e-1)" "unprognostic (1.52e-2)" "unprognostic (2.05e-1)" "unprognostic (5.45e-2)" "unprognostic (3.49e-1)" "unprognostic (5.08e-2)" 118.4 141.3 88.3 117.3 92.4 155.5 131.1 88.9 140.7 81.3 86.6 128.6 115.1 82.4 98.7 126.0 84.0 69.7 169.1 92.2 97.6 98.0 172.8 123.6 137.6 92.6 90.5 71.3 91.9 82.8 83.2 120.7 96.0 74.7 130.0 63.9 87.8 81.1 350.1 107.5 114.8 94.4 92.8 114.4 95.9 247.9 94.7 290.1 82.3 203.9 139.7 132.6 85.7 92.4 502.2 367.2 257.6 264.9 209.8 214.5 523.1 252.2 300.3 368.2 329.0 338.8 341.7 322.9 492.1 244.4 220.4 337.5 306.6 280.0 434.5 337.9 170.1 257.6 233.6 1011.6 235.8 542.0 225.8 166.7 229.4 256.6 324.7 178.2 312.2 548.1 284.2 220.4 298.7 522.9 838.2 458.2 249.3 391.0 407.0 1249.4 261.3 256.9 312.8 634.9 275.1 230.8 285.5 402.2 274.7 211.9 473.8 351.4 267.1 235.8 231.8 245.7 283.6 234.0 576.3 605.9 192.4 335.7 272.0 232.1 364.6 242.2 241.0 344.8 243.0 212.8 230.9 248.9 373.6 171.5 182.5 217.5 131.9 300.6 343.7 385.3 317.0 711.5 88.3 92.4 88.9 140.7 92.2 97.6 92.6 90.5 96.0 92.8 94.7 92.4 20.8 44.8 40.7 20.2 37.7 33.3 14.9 37.2 69.4 13.7 16.5 15.0 1.4 22.8 45.7 14.7 25.0 32.2 24.8 22.4 21.5 34.2 156.3 21.2 14.9 30.5 18.0 56.8 32.7 36.7 26.0 28.4 46.4 28.2 54.5 10.1 29.6 20.0 22.6 25.2 31.2 18.3 22.4 36.7 89.5 474.9 22.7 62.2 24.9 22.5 34.1 8.6 34.0 20.6 29.4 32.8 19.5 17.3 114.6 15.9 43.1 25.4 59.5 19.4 13.1 17.8 31.3 35.1 20.0 89.8 33.1 41.3 53.7 9.2 22.2 17.1 PSMA7 "C6, HSPC, RC6-1, XAPC7" ENSG00000101182 "Proteasome 20S subunit alpha 7" O14818 20 62136733-62143440 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 753.9" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB046007, CAB046008, HPA047266" Approved NA NA 22000000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 59: Non-specific - Translation" "Cluster 39: CACO-2 - Unknown function" "Cluster 10: Non-specific - Unknown function" "CAB046007: AB_11128404, CAB046008: AB_2171861, HPA047266: AB_2680006" "unprognostic (1.49e-2)" "unprognostic (4.44e-2)" "unprognostic (1.78e-2)" "unprognostic (2.79e-2)" "unprognostic (6.36e-1)" "unprognostic (6.57e-3)" "prognostic unfavorable (2.54e-5)" "unprognostic (8.82e-2)" "unprognostic (1.87e-2)" "unprognostic (5.06e-3)" "unprognostic (1.16e-1)" "unprognostic (7.30e-2)" "unprognostic (7.04e-2)" "unprognostic (2.31e-1)" "unprognostic (2.21e-2)" "unprognostic (6.31e-2)" "unprognostic (1.98e-2)" 223.2 200.1 127.6 148.5 132.0 260.4 198.0 136.9 146.2 134.6 127.1 180.3 132.2 163.4 102.9 191.0 140.5 91.3 266.2 131.9 137.0 168.9 214.0 170.3 164.9 134.0 131.7 134.4 140.2 114.1 104.1 115.0 136.7 117.8 108.0 54.5 129.2 104.2 753.9 136.6 151.3 117.1 134.7 163.3 152.9 61.3 136.4 188.0 121.9 375.3 155.4 168.2 141.3 143.7 532.8 674.6 390.9 419.4 357.2 277.8 345.0 398.3 343.6 1024.7 428.8 1785.8 504.0 438.2 926.2 421.0 644.1 627.2 371.9 752.5 497.0 261.0 261.1 1009.7 641.9 913.2 454.0 434.3 570.4 297.9 602.0 525.1 454.5 248.8 509.2 436.1 439.2 419.2 441.8 568.6 696.1 673.6 332.5 595.0 859.8 476.9 753.5 482.6 385.3 515.4 526.2 321.6 625.9 777.1 701.9 252.7 468.3 643.3 416.1 898.9 725.4 473.3 631.1 286.9 483.9 531.2 626.7 327.7 536.1 754.4 682.6 801.5 536.5 692.6 458.2 579.3 533.3 531.4 632.2 522.7 415.1 427.3 582.2 421.7 720.3 676.3 723.4 1131.2 127.6 132.0 136.9 146.2 131.9 137.0 134.0 131.7 136.7 134.7 136.4 143.7 402.9 211.5 180.8 20.9 252.3 374.5 350.6 616.4 167.4 127.5 223.0 296.4 304.9 327.5 369.2 257.5 73.0 666.2 309.5 375.2 498.9 581.9 355.5 290.2 345.4 397.3 232.0 439.4 19.2 727.7 775.7 321.9 132.0 276.5 251.4 304.7 335.5 787.5 807.0 82.4 18.4 325.6 453.7 435.7 453.1 211.0 334.6 414.8 368.2 18.7 598.4 219.3 377.9 15.1 28.9 663.3 386.4 293.8 234.5 639.7 455.1 759.6 288.8 122.5 230.1 237.0 659.7 81.4 126.3 291.9 309.3 852.6 310.4 410.0 386.9 438.7 PSMA8 "MGC26605, PSMA7L" ENSG00000154611 "Proteasome 20S subunit alpha 8" Q8TAA3 18 26133852-26193355 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Differentiation, Spermatogenesis" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 10 "testis: 16.9" "Cell type enriched" "Detected in some" 6 "Spermatocytes: 229.1" "Not detected" "Not detected" "Not detected" "Not detected" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Group enriched" "Detected in some" 72 "Daudi: 25.5;JURKAT: 7.1;U-266/70: 15.9;U-266/84: 17.2" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 83: Testis - Spermatogenesis" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "unprognostic (5.39e-3)" "unprognostic (7.45e-5)" "unprognostic (2.94e-1)" "unprognostic (3.04e-2)" "unprognostic (1.59e-1)" "unprognostic (2.72e-1)" "unprognostic (1.99e-1)" "unprognostic (8.30e-2)" "unprognostic (7.54e-4)" "unprognostic (4.80e-2)" "unprognostic (1.15e-1)" "unprognostic (2.56e-1)" 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.3 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.2 0.1 16.9 0.0 0.5 0.0 0.0 1.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 25.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.9 17.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.6 1.4 0.8 1.2 0.0 1.2 0.9 1.9 0.1 0.4 0.0 0.7 1.6 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 2.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 2.5 0.4 0.1 0.0 0.0 10.3 0.0 0.0 0.1 0.0 0.4 0.6 0.0 2.8 0.1 0.0 0.0 0.0 0.3 0.7 0.1 0.2 0.0 0.4 0.0 0.0 0.0 0.2 6.9 1.2 0.3 1.8 1.0 0.0 0.0 1.0 0.0 0.3 0.0 0.0 1.5 2.4 0.0 0.0 0.0 0.0 0.0 6.6 0.0 0.0 229.1 37.2 0.0 0.0 1.0 0.7 0.5 0.0 0.0 PSMB1 "HC5, PMSB1" ENSG00000008018 "Proteasome 20S subunit beta 1" P20618 6 170535120-170553307 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 1197.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029635, HPA029637, CAB033911" Enhanced Supported Nucleoplasm NA NA 15000000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "CAB033911: AB_2268890, HPA029635: AB_10599738, HPA029637: AB_10601793" "unprognostic (2.78e-2)" "unprognostic (3.10e-2)" "unprognostic (6.73e-2)" "unprognostic (1.34e-1)" "unprognostic (1.20e-1)" "unprognostic (5.41e-3)" "unprognostic (2.36e-2)" "unprognostic (3.32e-2)" "unprognostic (8.39e-2)" "unprognostic (4.28e-2)" "unprognostic (3.07e-1)" "unprognostic (1.09e-1)" "prognostic unfavorable (3.76e-6)" "unprognostic (3.63e-1)" "unprognostic (7.50e-2)" "unprognostic (1.45e-3)" "unprognostic (9.62e-2)" 214.3 191.2 127.8 138.1 131.9 206.8 186.4 129.8 150.7 146.1 131.9 175.9 147.4 174.9 279.4 175.2 157.1 114.5 222.3 127.7 139.0 179.7 308.6 158.3 175.8 129.2 127.5 136.6 153.1 169.2 151.8 173.8 133.2 130.9 166.9 98.5 141.7 151.3 355.2 192.2 149.1 164.3 137.6 165.7 156.8 114.3 132.9 180.5 142.4 239.2 206.8 168.8 143.4 143.0 309.8 284.9 396.2 514.9 347.3 271.2 421.6 288.3 422.7 471.6 478.5 628.9 259.3 449.1 366.2 390.0 430.8 303.7 446.0 459.8 488.7 460.2 502.1 384.4 277.6 799.6 406.3 455.8 327.1 311.5 277.6 455.6 293.1 322.4 409.9 278.1 774.3 373.2 436.9 835.1 343.5 633.0 362.7 558.1 387.9 326.9 314.1 571.6 495.1 183.6 394.5 321.6 277.1 424.5 231.5 351.1 290.9 648.4 313.3 190.4 304.8 466.9 543.2 315.8 454.8 565.8 443.7 510.9 417.5 258.4 431.9 290.2 265.2 416.1 313.5 386.4 306.0 290.7 523.1 305.7 288.1 279.8 249.3 408.2 384.4 297.4 442.6 652.5 127.8 131.9 129.8 150.7 127.7 139.0 129.2 127.5 133.2 137.6 132.9 143.0 242.7 112.2 148.5 19.9 182.1 217.2 351.4 750.7 117.8 120.2 168.2 236.3 232.3 208.8 335.5 141.6 41.7 876.6 175.0 222.0 401.1 498.3 332.4 224.6 190.2 243.8 165.3 223.9 23.5 651.4 790.8 245.5 109.6 215.1 189.5 226.1 168.8 349.8 394.3 119.5 25.1 251.6 417.1 165.3 222.3 81.9 256.3 207.3 231.3 20.6 364.5 237.8 206.0 19.6 43.3 525.5 240.1 235.9 253.4 334.9 327.6 537.0 310.0 135.9 190.7 181.2 500.2 247.8 196.3 153.3 215.8 1197.8 182.1 283.7 276.7 365.4 PSMB10 "beta2i, LMP10, MECL1, MGC1665" ENSG00000205220 "Proteasome 20S subunit beta 10" P40306 16 67934506-67936864 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Hydrolase, Protease, Threonine protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 122.3" "Cell type enhanced" "Detected in many" "Proximal enterocytes: 173.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "REH: 183.4;RPMI-8226: 169.4;THP-1: 171.3;U-266/70: 189.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030224, HPA030225, CAB034384" Enhanced Approved Vesicles,Cytosol NA NA 1400000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 14: B-cells - Humoral immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 58: T-cells - T-cell receptor" Cytosol Vesicles "CAB034384: AB_2171876, HPA030224: AB_2673382, HPA030225: AB_10603231" "unprognostic (1.18e-2)" "unprognostic (1.90e-3)" "unprognostic (2.00e-1)" "unprognostic (2.53e-3)" "unprognostic (2.00e-1)" "unprognostic (1.85e-2)" "unprognostic (7.22e-2)" "unprognostic (3.35e-2)" "unprognostic (1.07e-1)" "unprognostic (2.60e-1)" "unprognostic (8.22e-2)" "unprognostic (1.79e-1)" "unprognostic (1.32e-2)" "unprognostic (2.97e-2)" "unprognostic (1.98e-1)" "unprognostic (1.32e-2)" "prognostic favorable (5.44e-4)" 26.3 26.9 5.7 81.8 6.0 71.3 24.9 6.9 8.8 18.9 6.6 51.6 110.5 18.4 5.7 22.8 30.4 31.2 16.2 5.6 8.0 35.1 37.1 42.2 122.3 12.6 7.4 14.6 15.0 6.3 13.2 23.1 8.6 28.9 22.9 0.4 65.1 22.4 6.8 18.1 95.8 14.0 9.5 102.7 62.5 5.3 7.8 61.9 23.6 3.5 37.5 36.4 18.6 11.7 31.8 26.9 0.7 2.2 6.7 17.2 99.6 10.8 42.3 38.5 50.6 13.9 148.5 111.9 23.4 13.2 12.9 47.9 0.0 13.4 2.9 50.3 1.9 39.2 7.6 16.4 65.7 78.5 115.2 26.9 8.4 15.2 1.5 12.1 20.6 32.1 3.6 48.2 9.0 42.6 140.7 84.9 1.0 1.1 10.2 183.4 8.3 169.4 31.6 52.5 0.9 2.3 31.1 67.5 17.2 0.4 14.5 171.3 32.0 21.2 6.6 9.7 15.3 189.8 43.9 88.4 57.1 97.9 47.0 539.5 714.6 571.1 511.7 787.1 376.4 402.6 397.9 437.3 594.8 390.2 326.2 364.6 786.2 588.6 607.4 604.4 495.9 1155.7 5.7 6.0 6.9 8.8 5.6 8.0 12.6 7.4 8.6 9.5 7.8 11.7 24.7 22.4 26.8 4.6 72.9 17.2 14.3 101.2 26.2 1.0 15.8 13.8 1.6 28.6 43.9 18.4 0.0 29.5 66.2 80.8 23.5 58.5 14.0 17.6 20.1 22.8 16.3 32.6 3.4 104.3 30.0 23.4 110.6 12.3 51.9 7.2 37.1 10.2 87.4 0.0 5.0 74.6 52.9 81.9 66.4 35.9 30.1 88.5 48.0 9.4 123.3 3.0 112.3 2.5 7.3 51.2 139.7 21.1 110.5 12.1 173.5 69.4 83.9 1.1 19.7 10.3 26.6 16.4 7.5 24.1 9.9 22.6 93.9 16.9 79.5 24.8 PSMB11 beta5t ENSG00000222028 "Proteasome subunit beta 11" A5LHX3 14 23042212-23044060 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 93 "lymphoid tissue: 30.6" "Group enriched" "Detected in some" 10 "Early spermatids: 2.4;Late spermatids: 1.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in single" 7 "olfactory bulb: 1.9" "Not detected" "Not detected" "HPA028967, HPA056970" Enhanced NA NA "Cluster 63: T-cells - Adaptive immune response" "Cluster 23: Spermatids - Flagellum & Golgi organization" "HPA028967: AB_2732444, HPA056970: AB_2683293" "unprognostic (7.96e-2)" "unprognostic (2.77e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 30.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PSMB2 HC7-I ENSG00000126067 "Proteasome 20S subunit beta 2" P49721 1 35599541-35641526 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026322, HPA026324" Approved Enhanced Nucleoplasm NA NA 9700000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA026322: AB_1855821, HPA026324: AB_1855822" "unprognostic (3.54e-2)" "unprognostic (8.53e-2)" "unprognostic (1.63e-3)" "unprognostic (6.93e-2)" "unprognostic (6.41e-2)" "unprognostic (1.37e-1)" "prognostic unfavorable (3.49e-7)" "unprognostic (2.81e-2)" "unprognostic (5.23e-2)" "unprognostic (3.34e-3)" "unprognostic (7.87e-2)" "unprognostic (4.45e-1)" "prognostic unfavorable (2.80e-6)" "unprognostic (1.65e-1)" "unprognostic (2.83e-1)" "unprognostic (3.77e-2)" "unprognostic (2.93e-2)" 26.4 29.3 10.0 13.9 10.3 21.7 25.0 9.7 11.6 23.6 9.4 24.3 12.9 26.9 11.5 31.8 21.9 9.1 27.3 10.6 10.4 22.6 45.9 25.6 15.8 9.9 9.7 21.0 25.2 11.3 19.6 15.2 11.0 20.0 12.7 12.1 22.3 10.8 63.1 30.9 23.2 13.4 9.9 25.4 24.2 15.6 9.5 20.5 18.7 14.8 16.7 22.9 23.9 11.8 68.8 42.4 45.5 32.2 23.3 27.9 55.5 31.8 36.6 63.2 51.1 51.6 79.3 68.8 71.3 37.6 38.6 41.2 59.3 53.4 54.5 54.5 54.1 63.4 44.5 50.1 41.4 66.1 34.7 30.4 33.4 77.0 36.8 25.9 50.8 54.1 76.6 37.7 41.9 30.7 85.5 50.1 59.3 29.7 44.0 52.3 47.5 48.7 45.3 35.9 39.8 30.1 36.0 34.5 52.1 50.3 24.9 29.3 35.2 32.0 37.5 30.9 76.5 31.8 55.0 66.9 49.9 70.4 55.6 20.5 23.6 18.2 19.6 30.3 19.9 22.3 19.3 20.6 26.4 18.5 14.0 17.3 8.8 23.6 35.4 27.4 26.3 26.1 10.0 10.3 9.7 11.6 10.6 10.4 9.9 9.7 11.0 9.9 9.5 11.8 110.8 64.1 68.9 6.2 80.4 111.1 145.2 298.5 50.7 48.0 65.8 95.1 59.8 67.2 145.0 66.2 16.7 406.6 83.6 72.4 144.8 286.2 118.0 95.4 78.8 115.9 98.3 78.7 20.8 227.3 341.0 101.3 61.2 75.9 35.4 109.6 85.6 158.1 222.6 58.9 20.9 96.9 187.2 92.7 70.3 22.8 100.6 94.1 76.5 15.9 184.1 68.4 87.6 17.1 23.4 252.0 76.6 91.4 141.7 186.0 108.5 221.7 126.8 50.4 92.1 66.8 291.4 224.4 144.0 80.4 111.5 442.1 81.4 123.9 111.7 178.9 PSMB3 "HC10-II, MGC4147" ENSG00000277791 "Proteasome 20S subunit beta 3" P49720 17 38752741-38764225 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042775, HPA048147" Approved NA NA 25000000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" "HPA042775: AB_2678158, HPA048147: AB_2680285" "unprognostic (1.86e-1)" "unprognostic (4.84e-3)" "unprognostic (1.44e-1)" "unprognostic (4.80e-2)" "unprognostic (6.68e-2)" "unprognostic (1.14e-3)" "unprognostic (5.46e-2)" "unprognostic (2.46e-2)" "unprognostic (2.02e-1)" "unprognostic (1.75e-2)" "unprognostic (3.65e-1)" "unprognostic (1.13e-1)" "prognostic unfavorable (1.71e-6)" "unprognostic (4.44e-1)" "unprognostic (1.28e-1)" "unprognostic (2.42e-3)" "unprognostic (6.03e-2)" 95.7 139.3 65.9 95.7 70.8 138.7 92.9 68.2 76.1 83.0 67.4 105.6 82.5 90.6 101.8 110.9 81.4 73.0 154.2 74.4 80.3 120.7 187.3 101.8 137.0 70.0 73.2 59.3 78.1 86.2 81.4 90.9 70.6 85.6 106.1 42.4 84.1 66.6 201.7 99.0 90.3 92.7 69.4 122.0 93.8 53.2 76.1 106.3 87.6 119.5 132.5 102.8 83.0 80.1 246.1 457.3 168.8 277.2 180.9 158.6 237.1 167.6 265.8 563.8 489.1 486.3 324.1 279.5 276.3 228.8 371.1 401.6 279.3 294.3 301.1 373.6 500.2 184.2 226.6 562.5 96.5 289.3 278.1 151.0 184.6 393.5 131.1 132.9 289.3 283.1 301.2 320.4 246.2 319.6 461.1 457.0 250.6 278.8 328.3 261.1 383.3 446.2 312.1 253.4 216.8 145.7 191.8 157.3 201.3 243.8 360.1 356.6 173.1 138.0 269.5 308.9 421.1 202.1 367.2 397.7 285.2 294.8 242.0 227.2 323.7 150.4 176.6 271.4 118.1 148.5 145.2 154.4 274.5 114.6 93.0 94.9 569.6 142.8 209.6 352.6 176.1 372.0 65.9 70.8 68.2 76.1 74.4 80.3 70.0 73.2 70.6 69.4 76.1 80.1 146.2 76.9 124.5 8.8 142.0 199.6 203.6 517.8 79.1 66.7 100.9 105.8 328.0 104.4 281.6 176.6 25.0 434.0 141.4 215.0 406.9 362.1 51.5 140.6 123.8 185.5 133.4 156.4 8.6 497.7 428.3 160.8 100.9 117.7 154.0 110.0 118.9 247.6 416.7 30.3 7.8 207.1 368.2 161.5 266.5 48.2 149.5 231.8 200.9 7.5 309.8 167.5 179.2 3.0 12.6 401.0 242.9 145.9 205.1 189.9 219.9 642.6 274.9 72.2 124.9 110.2 507.6 152.2 76.7 114.0 201.5 504.2 154.0 186.7 224.7 239.9 PSMB4 "HN3, PROS26" ENSG00000159377 "Proteasome 20S subunit beta 4" P28070 1 151399560-151401937 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Host-virus interaction" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006700, HPA073499" Approved Uncertain Nucleoplasm,Mitochondria NA NA 12000000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 10: Non-specific - Unknown function" Nucleoplasm Mitochondria "HPA006700: AB_1079704, HPA073499: " "unprognostic (1.11e-1)" "unprognostic (1.44e-1)" "unprognostic (2.69e-1)" "unprognostic (2.52e-1)" "unprognostic (1.63e-1)" "unprognostic (5.74e-2)" "prognostic unfavorable (7.45e-4)" "unprognostic (2.27e-1)" "unprognostic (1.69e-1)" "unprognostic (4.37e-3)" "unprognostic (3.73e-1)" "unprognostic (3.77e-1)" "prognostic unfavorable (2.90e-10)" "unprognostic (5.33e-2)" "unprognostic (2.46e-2)" "unprognostic (3.82e-2)" "unprognostic (5.85e-2)" 189.5 242.7 200.2 156.7 202.1 172.9 174.2 210.6 212.4 167.0 201.9 194.3 150.0 195.5 225.6 170.4 178.3 139.1 241.8 201.7 212.9 196.6 269.5 143.2 214.0 206.8 203.9 179.5 164.0 218.6 168.0 187.1 211.7 162.4 166.4 94.3 169.6 190.6 299.1 186.6 152.8 191.7 210.5 173.8 171.8 69.0 205.8 233.5 156.1 237.5 235.4 196.7 151.3 218.4 428.3 451.9 373.0 447.8 412.9 392.3 507.8 247.6 549.2 719.3 503.1 608.6 569.5 384.1 730.7 424.3 379.1 419.7 383.2 472.7 407.6 535.6 391.1 268.6 320.8 463.3 444.4 377.0 355.7 431.7 444.8 672.5 276.2 364.8 506.1 419.1 434.3 740.0 512.7 1174.2 463.5 452.0 952.8 638.6 576.2 433.8 266.9 688.2 594.4 354.2 408.6 488.0 283.6 626.5 879.8 459.1 564.1 594.6 320.7 310.4 326.1 333.8 557.0 726.9 902.5 769.1 459.5 337.8 667.8 291.8 343.4 227.0 265.0 342.2 314.8 293.6 303.7 301.0 421.7 257.5 260.4 272.8 251.5 347.3 270.5 468.1 405.1 395.2 200.2 202.1 210.6 212.4 201.7 212.9 206.8 203.9 211.7 210.5 205.8 218.4 72.2 153.8 127.4 10.1 82.2 76.6 81.9 131.5 82.0 56.3 62.0 71.6 128.0 68.6 123.2 71.7 16.7 209.8 79.7 87.8 103.7 127.9 16.0 118.1 107.5 97.7 66.4 87.1 10.4 195.8 146.7 91.9 47.4 110.0 111.1 81.1 92.8 151.7 125.0 48.8 11.5 80.5 89.5 108.1 88.8 15.6 104.4 89.4 96.0 12.2 186.2 89.5 64.9 6.6 14.7 131.7 75.0 105.3 89.1 75.5 117.5 148.9 141.5 62.8 65.7 86.0 127.5 54.5 49.7 80.0 75.9 267.3 80.2 124.5 96.0 89.1 PSMB5 MB1 ENSG00000100804 "Proteasome 20S subunit beta 5" P28074 14 23016543-23035230 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Hydrolase, Protease, Threonine protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Hep G2: 1146.8" "Low region specificity" "Detected in all" "HPA049518, HPA061796" Approved Supported Nucleoplasm,Centrosome NA NA 6200000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 80: Striated muscle - Unknown function" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Centrosome" "HPA049518: AB_2680802, HPA061796: AB_2684612" "unprognostic (3.03e-1)" "unprognostic (1.99e-2)" "unprognostic (8.35e-2)" "unprognostic (6.13e-2)" "unprognostic (1.24e-1)" "prognostic unfavorable (2.85e-4)" "prognostic unfavorable (2.90e-5)" "unprognostic (2.55e-2)" "unprognostic (9.95e-2)" "prognostic favorable (1.08e-4)" "unprognostic (2.06e-1)" "unprognostic (1.19e-1)" "unprognostic (5.30e-2)" "unprognostic (1.75e-1)" "unprognostic (1.95e-1)" "unprognostic (4.95e-2)" "prognostic unfavorable (4.73e-4)" 84.0 116.0 129.1 58.7 134.2 32.0 81.0 141.4 134.3 71.3 141.1 80.8 61.1 71.0 129.5 102.3 93.3 61.0 136.8 136.4 141.1 98.5 119.1 64.7 49.0 137.9 138.4 61.6 80.9 143.5 80.1 90.1 145.2 76.8 88.7 59.7 73.5 78.6 332.4 76.0 53.0 103.4 141.3 50.3 81.0 57.8 136.5 79.5 72.3 274.1 68.6 92.1 68.4 146.5 181.0 398.9 250.6 245.5 360.4 318.9 261.8 252.0 307.3 446.1 376.1 329.2 282.2 228.0 228.1 352.1 298.4 239.7 428.4 320.2 401.9 139.9 311.4 146.9 260.3 1146.8 287.3 170.2 162.1 354.2 292.0 331.8 264.1 289.7 475.5 190.5 218.6 121.5 376.0 557.2 97.6 218.4 285.7 341.6 631.4 133.8 197.7 150.7 349.9 256.6 336.0 251.0 179.9 354.8 245.4 322.2 175.0 217.7 254.1 212.4 210.1 197.3 247.8 99.7 218.4 158.8 164.9 140.8 274.6 97.8 127.6 58.0 89.4 125.6 103.5 103.8 101.1 85.1 137.6 99.7 135.0 102.5 48.1 67.4 92.7 172.4 91.3 147.8 129.1 134.2 141.4 134.3 136.4 141.1 137.9 138.4 145.2 141.3 136.5 146.5 94.2 76.9 69.2 16.0 47.3 140.2 174.1 461.5 100.7 61.0 130.4 135.5 157.6 112.9 240.4 95.6 29.2 400.1 40.2 75.0 275.9 277.7 93.0 149.0 109.5 150.0 154.6 82.5 17.6 231.3 435.2 139.9 73.9 88.0 31.0 162.6 89.6 171.6 221.6 70.7 18.0 109.2 329.6 57.5 80.9 106.4 118.7 64.0 115.6 15.9 138.2 170.8 25.7 11.6 29.4 285.7 88.0 122.2 78.2 185.1 81.2 437.8 268.9 71.8 98.6 87.1 355.1 174.4 81.6 144.7 157.1 430.2 43.4 215.7 148.9 215.3 PSMB6 "DELTA, Y" ENSG00000142507 "Proteasome 20S subunit beta 6" P28072 17 4796144-4798502 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023312, HPA063656" Supported Supported Nucleoplasm,Cytosol NA NA 1400000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm Cytosol "HPA023312: AB_1855828, HPA063656: AB_2685078" "unprognostic (2.71e-1)" "unprognostic (1.86e-2)" "unprognostic (2.75e-1)" "unprognostic (3.32e-3)" "unprognostic (8.80e-2)" "unprognostic (1.44e-1)" "unprognostic (2.73e-1)" "unprognostic (2.22e-2)" "unprognostic (2.37e-1)" "unprognostic (2.64e-2)" "unprognostic (1.98e-2)" "unprognostic (7.47e-2)" "prognostic unfavorable (5.93e-4)" "unprognostic (1.81e-1)" "unprognostic (2.34e-1)" "unprognostic (5.27e-2)" "unprognostic (5.66e-2)" 92.7 107.8 130.1 82.2 133.7 126.9 107.0 138.1 141.2 92.6 137.4 116.3 76.9 101.9 150.9 140.6 99.2 68.3 201.6 132.8 138.1 134.8 184.6 86.2 90.1 135.7 134.1 63.7 99.3 173.3 82.5 119.8 138.7 84.8 118.3 62.6 100.0 114.2 358.6 114.9 77.0 135.3 136.0 90.4 103.8 76.6 133.5 147.4 88.7 339.5 140.5 110.6 89.2 140.3 279.8 478.2 251.6 216.4 209.9 188.1 289.7 144.1 300.1 431.3 336.0 358.7 220.5 215.0 277.9 348.1 246.5 273.8 388.0 404.4 418.0 281.9 409.7 128.0 315.3 422.7 242.0 133.5 194.4 178.3 305.1 377.4 355.7 241.5 426.5 335.8 199.4 316.6 336.1 331.8 237.4 221.8 214.1 356.2 328.2 261.9 178.7 284.6 326.6 185.3 146.9 179.9 206.6 158.9 148.6 261.4 194.5 147.2 205.1 210.8 158.9 286.4 355.2 130.8 191.8 132.9 301.3 242.1 259.3 410.6 603.3 343.2 347.5 589.9 355.9 668.6 373.1 384.0 624.9 640.8 319.8 329.3 210.5 424.4 549.4 585.5 556.2 817.2 130.1 133.7 138.1 141.2 132.8 138.1 135.7 134.1 138.7 136.0 133.5 140.3 156.3 134.6 113.3 8.5 118.3 229.2 184.1 410.8 112.1 65.5 124.6 153.4 454.8 141.5 253.9 134.3 16.7 587.3 142.8 178.0 358.1 321.6 245.2 110.9 108.1 164.7 148.4 183.7 7.6 349.9 418.2 171.5 105.5 116.0 105.2 156.1 99.6 235.4 346.3 32.0 7.2 173.0 311.3 111.7 272.1 52.9 109.6 159.8 236.5 4.7 298.9 183.4 109.2 9.0 16.9 351.3 163.4 123.0 244.7 191.7 188.6 564.6 193.3 81.3 111.7 119.8 486.8 175.1 84.7 178.6 277.2 664.5 125.9 172.6 177.7 217.3 PSMB7 Z ENSG00000136930 "Proteasome 20S subunit beta 7" Q99436 9 124353465-124415444 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA052408, HPA054902" Supported Enhanced "Nucleoplasm,Nuclear bodies,Cytosol" No No 2100000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 16: U-266 - Nucleosome" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "Nuclear bodies, Cytosol" "HPA052408: AB_2681820, HPA054902: AB_2682635" "unprognostic (7.75e-2)" "unprognostic (1.83e-2)" "unprognostic (1.27e-1)" "unprognostic (3.64e-3)" "unprognostic (2.83e-1)" "unprognostic (1.25e-1)" "unprognostic (2.02e-2)" "unprognostic (2.24e-3)" "unprognostic (9.03e-2)" "unprognostic (3.60e-1)" "unprognostic (2.99e-1)" "unprognostic (1.78e-1)" "unprognostic (1.26e-2)" "unprognostic (1.67e-1)" "unprognostic (3.45e-1)" "unprognostic (1.93e-3)" "unprognostic (3.98e-2)" 115.7 180.4 129.4 103.9 136.9 189.7 122.6 132.7 144.8 99.8 119.6 103.5 98.7 102.9 147.0 139.1 94.6 87.2 212.0 135.8 137.0 150.9 222.9 91.4 112.7 138.2 139.5 101.6 142.2 143.4 74.7 120.2 138.2 94.8 107.8 81.0 114.3 75.0 277.8 166.2 98.3 92.7 131.5 91.7 115.3 155.2 137.8 147.6 91.3 205.3 124.6 110.5 104.2 135.0 344.4 411.7 275.8 336.4 190.4 224.8 396.1 325.3 447.6 461.7 315.1 546.3 327.1 389.2 256.8 307.4 457.2 480.2 346.7 345.4 420.0 375.0 299.3 245.3 673.3 460.0 428.5 491.6 234.3 270.8 299.6 483.7 478.5 355.1 394.3 345.5 507.9 269.8 362.4 600.0 355.9 329.5 409.7 519.6 581.5 309.8 411.4 457.2 331.5 221.9 323.7 263.6 310.4 394.0 498.4 268.7 454.8 212.7 315.9 297.5 240.7 384.9 499.0 289.9 873.7 394.9 498.1 297.8 429.1 162.7 201.5 154.5 128.3 211.4 138.9 177.8 145.7 142.5 221.1 159.7 138.2 135.9 87.0 185.3 206.8 187.5 226.0 264.8 129.4 136.9 132.7 144.8 135.8 137.0 138.2 139.5 138.2 131.5 137.8 135.0 73.1 76.9 77.6 26.1 88.0 194.1 184.4 309.1 39.9 41.5 113.9 97.5 147.3 134.4 150.0 69.9 22.9 441.4 83.0 146.9 330.6 351.3 404.6 105.7 93.8 123.8 141.2 93.8 38.4 392.7 356.7 112.3 52.5 90.3 104.6 130.8 107.1 277.3 237.2 33.7 31.9 162.5 160.7 122.1 148.4 472.8 139.1 92.5 199.3 33.7 168.5 119.7 113.3 30.7 44.8 393.6 143.7 125.3 69.9 158.0 173.6 484.7 135.7 61.6 85.5 133.8 221.2 330.6 190.4 60.4 218.9 488.7 81.4 135.8 181.2 201.3 PSMB8 "beta5i, D6S216E, LMP7, PSMB5i, RING10" ENSG00000204264 "Proteasome 20S subunit beta 8" P28062 6 32840717-32844679 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Differentiation, Host-virus interaction, Immunity" "Hydrolase, Protease, Threonine protease" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046995, HPA050327" Enhanced Approved "Vesicles,Cytokinetic bridge" Yes No 2700000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 64: Macrophages - Immune response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 63: NK-cells & T-cells - Immune response" Vesicles "Cytokinetic bridge" "HPA046995: AB_2679896, HPA050327: AB_2681088" "prognostic favorable (5.08e-4)" "unprognostic (4.22e-2)" "unprognostic (2.39e-2)" "prognostic favorable (7.16e-4)" "unprognostic (1.92e-1)" "unprognostic (1.68e-1)" "unprognostic (7.78e-2)" "unprognostic (1.09e-1)" "unprognostic (5.71e-2)" "unprognostic (1.17e-2)" "unprognostic (2.79e-2)" "unprognostic (1.47e-1)" "unprognostic (4.14e-2)" "unprognostic (1.24e-1)" "unprognostic (4.35e-2)" "unprognostic (1.97e-3)" "unprognostic (7.11e-3)" 62.7 76.9 3.3 11.2 3.4 9.8 56.5 3.3 7.3 42.7 3.4 79.9 12.9 41.3 3.2 59.5 41.6 5.8 34.2 3.4 3.5 63.7 99.2 78.2 18.2 4.3 3.4 32.1 29.5 8.2 26.6 4.4 3.7 45.2 20.4 0.7 44.2 6.4 14.4 58.0 93.9 8.9 4.0 150.4 57.0 5.9 3.6 13.5 40.8 0.1 17.2 41.3 48.1 4.1 15.1 3.9 0.3 0.0 5.1 13.1 11.2 4.9 22.9 29.1 39.3 0.0 20.9 45.7 9.4 10.5 25.5 8.1 6.8 16.6 8.0 19.2 0.0 27.6 5.9 0.3 30.3 5.2 7.5 14.9 10.3 12.9 6.8 1.9 18.1 11.8 1.1 8.1 6.1 0.1 12.9 11.7 0.1 0.0 7.3 29.3 1.3 24.1 21.3 4.9 0.8 0.2 8.6 10.4 8.5 0.1 7.0 41.0 4.3 8.8 7.6 7.8 0.6 21.0 15.9 11.2 2.2 27.7 9.0 56.8 70.3 94.6 58.1 88.0 51.2 73.4 49.1 61.1 67.5 71.1 34.8 49.6 90.2 63.0 78.2 58.5 81.2 156.0 3.3 3.4 3.3 7.3 3.4 3.5 4.3 3.4 3.7 4.0 3.6 4.1 237.0 38.5 55.8 2.9 162.0 84.4 64.1 183.7 54.7 1.8 85.3 92.5 8.7 71.4 103.2 62.5 0.0 2.7 211.2 219.9 86.1 219.4 0.6 63.2 74.9 158.5 65.7 45.0 0.1 247.6 18.3 60.7 93.8 81.5 50.7 51.4 114.5 75.0 165.9 6.7 0.5 243.8 120.1 143.5 94.9 1.9 39.1 128.2 56.9 10.3 214.3 39.9 279.1 3.0 0.7 179.6 287.9 30.5 153.2 100.1 319.8 78.9 103.2 3.0 39.5 33.2 56.8 0.4 1.2 60.5 79.6 2.7 181.6 110.9 222.6 121.6 PSMB9 "beta1i, LMP2, PSMB6i, RING12" ENSG00000240065 "Proteasome 20S subunit beta 9" P28065 6 32844136-32859851 "Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, Immunity" "Hydrolase, Protease, Threonine protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 160.9" "Cell type enhanced" "Detected in many" "monocytes: 323.0;NK-cells: 495.4;Proximal enterocytes: 318.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+ SV40 Large T+ RasG12V: 27.7;Daudi: 40.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB015180, HPA042818, HPA053280" Enhanced Supported Cytosol NA NA 340000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 64: Macrophages - Immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "CAB015180: AB_2172368, HPA042818: AB_2678186, HPA053280: AB_2682098" "unprognostic (1.09e-2)" "unprognostic (1.68e-2)" "unprognostic (1.26e-2)" "unprognostic (2.18e-3)" "unprognostic (7.84e-2)" "unprognostic (1.89e-1)" "unprognostic (5.68e-2)" "unprognostic (6.67e-2)" "unprognostic (1.56e-2)" "unprognostic (6.50e-3)" "unprognostic (1.87e-3)" "unprognostic (1.84e-1)" "prognostic unfavorable (1.33e-4)" "unprognostic (2.65e-1)" "unprognostic (1.09e-1)" "unprognostic (4.96e-3)" "unprognostic (5.99e-2)" 47.0 31.1 4.8 18.4 4.9 6.9 41.4 4.3 5.5 28.8 2.6 38.4 10.2 26.8 2.3 25.7 25.9 4.7 31.6 4.8 5.6 36.3 37.4 60.2 26.2 7.6 4.9 18.1 12.1 1.5 14.0 3.4 5.9 26.5 8.7 1.3 20.3 5.0 11.9 27.7 78.1 5.7 5.7 160.9 26.5 4.9 5.1 15.0 28.7 3.8 22.2 23.6 30.8 5.8 5.5 0.3 0.0 0.2 3.4 8.5 3.0 0.7 11.5 17.3 27.7 0.0 3.1 40.8 1.3 2.9 14.3 10.0 0.2 5.8 2.6 9.3 0.1 17.6 0.7 0.8 17.3 1.8 2.2 2.1 0.3 7.0 1.0 3.3 2.7 10.1 1.4 12.8 1.9 1.0 16.1 8.0 0.0 0.0 0.8 19.0 1.2 7.4 2.1 2.5 0.0 0.0 1.0 2.1 10.7 0.0 4.4 10.3 0.0 2.5 1.6 14.7 1.2 11.3 23.9 9.3 7.5 6.8 4.0 92.7 30.3 75.6 56.1 55.8 45.9 59.7 45.1 55.9 26.6 45.3 41.0 49.6 96.3 61.5 60.9 20.5 61.0 46.2 4.8 4.9 4.3 5.5 4.8 5.6 7.6 4.9 5.9 5.7 5.1 5.8 258.6 41.7 51.1 1.3 197.2 72.5 37.4 155.6 30.1 2.4 25.3 47.0 7.3 50.1 64.8 25.8 0.0 1.5 216.2 88.0 19.6 116.6 1.3 28.9 47.5 146.5 33.5 29.9 0.0 115.6 6.6 45.1 34.1 42.6 77.3 20.0 119.6 26.6 117.2 0.0 0.1 148.0 99.7 126.8 155.7 2.1 29.2 145.2 35.6 8.4 323.0 22.7 495.4 0.5 8.3 67.8 150.3 15.8 136.1 40.4 318.5 40.5 133.7 1.7 32.9 23.1 50.8 1.5 7.4 21.0 58.7 1.4 241.8 45.3 110.6 39.1 PSMD14 "pad1, POH1, Rpn11" ENSG00000115233 "Proteasome 26S subunit, non-ATPase 14" O00487 2 161308425-161411717 "Enzymes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002114, HPA003828" Approved Supported Nucleoplasm NA NA 26000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA002114: AB_1855850, HPA003828: AB_2667057" "unprognostic (3.50e-3)" "unprognostic (1.48e-1)" "unprognostic (9.61e-2)" "unprognostic (6.63e-2)" "unprognostic (2.57e-1)" "unprognostic (7.61e-3)" "prognostic unfavorable (2.66e-8)" "unprognostic (3.11e-2)" "unprognostic (4.04e-2)" "unprognostic (3.90e-3)" "unprognostic (9.84e-3)" "unprognostic (3.02e-1)" "prognostic unfavorable (3.10e-6)" "unprognostic (2.86e-2)" "unprognostic (4.70e-2)" "unprognostic (3.54e-1)" "unprognostic (1.66e-1)" 35.2 38.3 38.6 39.7 40.0 38.8 36.4 42.5 47.5 26.2 36.7 35.2 29.1 24.7 30.1 40.7 27.3 23.7 44.6 40.7 43.3 44.4 48.4 26.9 37.8 42.1 41.7 14.5 25.6 51.1 21.4 42.0 43.7 31.0 41.0 37.9 20.8 29.9 98.0 33.2 26.4 39.6 43.8 22.9 27.2 38.7 41.1 49.7 34.7 76.0 52.0 42.5 19.6 46.6 170.3 145.8 158.8 140.8 113.9 97.0 194.2 173.6 168.2 246.1 198.6 216.2 140.2 200.2 258.0 128.7 144.3 126.5 176.8 185.6 244.6 210.3 133.1 200.8 110.8 245.9 139.7 196.7 113.8 74.4 138.8 277.4 256.8 94.0 185.5 117.1 222.1 139.6 207.7 164.1 145.0 148.0 220.5 124.3 218.2 123.6 154.4 196.0 218.6 145.0 138.4 101.3 117.8 131.7 167.5 131.4 90.2 124.3 147.2 162.7 152.4 111.6 193.8 82.5 242.7 186.7 174.1 129.6 182.2 47.4 48.2 25.2 65.3 69.6 68.7 64.2 69.4 71.0 75.4 57.4 55.4 66.5 4.9 70.2 56.2 74.5 83.7 73.3 38.6 40.0 42.5 47.5 40.7 43.3 42.1 41.7 43.7 43.8 41.1 46.6 40.1 51.3 38.2 35.3 49.4 49.5 48.1 146.8 25.0 43.7 40.2 36.2 89.8 52.9 80.3 23.9 18.8 159.5 60.4 47.7 90.1 124.3 82.5 52.4 51.8 49.9 52.5 56.2 64.0 118.3 154.6 48.1 29.6 58.4 51.2 59.0 31.8 125.3 104.7 47.1 56.1 53.5 118.0 41.1 40.0 36.0 27.7 46.1 48.0 25.3 61.1 87.7 44.3 50.3 64.6 155.0 48.0 34.3 60.2 57.0 36.5 106.1 55.4 60.6 32.9 36.6 64.5 137.0 77.7 34.3 56.0 220.3 47.8 63.6 64.5 50.8 PSMD7 "MOV34, P40, Rpn8, S12" ENSG00000103035 "Proteasome 26S subunit, non-ATPase 7" P51665 16 74296814-74306288 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 596.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB019379, HPA049824, HPA056069" Enhanced Enhanced Nucleoplasm NA NA 190000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "CAB019379: , HPA049824: AB_2680899, HPA056069: AB_2683025" "unprognostic (4.75e-3)" "unprognostic (1.30e-1)" "unprognostic (2.84e-2)" "unprognostic (6.95e-2)" "unprognostic (7.62e-2)" "prognostic unfavorable (6.64e-5)" "prognostic unfavorable (7.71e-6)" "unprognostic (1.97e-2)" "unprognostic (6.51e-2)" "unprognostic (1.91e-2)" "unprognostic (9.34e-3)" "unprognostic (1.34e-2)" "unprognostic (2.52e-2)" "unprognostic (5.06e-3)" "unprognostic (7.04e-2)" "unprognostic (2.12e-1)" "unprognostic (1.86e-2)" 68.9 78.8 51.6 52.1 52.9 126.7 57.5 54.5 69.3 50.1 50.9 75.8 47.3 59.5 59.3 85.8 44.0 41.2 124.8 53.0 54.2 57.3 75.1 52.6 62.3 54.3 54.1 37.8 49.0 49.0 41.7 70.2 55.6 68.3 65.4 47.3 59.7 59.2 265.8 85.5 55.6 62.4 54.3 56.5 58.0 42.0 55.0 71.9 42.0 159.5 71.2 73.1 62.2 56.7 140.1 226.2 170.6 89.0 120.1 122.1 209.8 191.6 166.2 236.2 212.7 301.9 189.8 190.1 207.7 156.7 103.2 176.3 135.0 175.1 215.4 113.3 146.3 147.2 169.1 235.9 156.0 241.3 241.3 112.4 176.3 213.4 213.0 106.0 207.0 119.2 222.2 82.1 153.5 345.4 147.0 232.1 184.9 145.0 113.8 198.8 106.9 251.6 125.1 207.3 106.9 119.3 185.7 70.4 114.9 130.5 148.7 166.6 187.5 137.5 116.0 152.5 146.5 174.6 241.4 560.2 186.6 174.1 145.2 152.4 163.6 193.4 133.2 176.2 130.5 149.7 131.8 141.2 201.9 110.5 126.6 131.2 98.7 139.5 187.4 172.2 168.2 187.8 51.6 52.9 54.5 69.3 53.0 54.2 54.3 54.1 55.6 54.3 55.0 56.7 74.4 67.3 59.4 16.6 84.2 104.4 183.5 167.8 64.3 59.6 47.0 47.5 53.3 57.2 114.9 46.0 8.4 337.1 69.5 120.4 80.3 158.5 153.8 76.3 80.6 96.2 85.5 121.0 22.7 190.9 229.8 87.7 67.8 80.3 103.9 76.7 66.0 147.6 188.5 57.2 21.3 100.1 122.1 75.1 91.2 25.3 56.5 95.1 99.6 9.4 119.5 86.0 81.4 15.6 25.7 164.0 104.1 65.5 121.4 259.6 93.9 109.4 88.1 59.9 92.1 68.4 186.1 184.2 88.7 103.6 129.3 596.1 86.2 114.0 110.3 197.8 RBP3 "D10S64, D10S65, D10S66, RP66" ENSG00000265203 "Retinol binding protein 3" P10745 10 47348363-47357881 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted secreted proteins" Transport "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 335 "retina: 542.3" "Group enriched" "Detected in some" 11 "Cone photoreceptor cells: 2070.4;Rod photoreceptor cells: 1610.0" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enhanced" "Detected in single" "hippocampal formation: 1.3" "Low region specificity" "Detected in many" "HPA041301, HPA044239" Enhanced "Secreted in other tissues" NA NA "Cluster 79: Retina - Phototransduction" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA041301: AB_2677398, HPA044239: AB_2678868" "unprognostic (3.48e-2)" "unprognostic (4.78e-3)" "unprognostic (1.36e-2)" "unprognostic (4.02e-2)" "unprognostic (1.40e-1)" "unprognostic (1.58e-2)" "unprognostic (5.09e-2)" "unprognostic (5.14e-3)" "unprognostic (7.44e-2)" "unprognostic (1.23e-1)" "unprognostic (4.68e-3)" 0.0 0.0 0.3 0.0 0.4 0.0 0.0 0.1 0.3 0.0 0.9 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 1.2 1.6 0.0 0.0 0.0 0.0 0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 542.3 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.1 0.3 1.2 1.6 0.5 0.3 0.6 0.1 0.4 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 157.7 0.0 0.0 0.5 0.0 0.0 0.0 2070.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 43.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 148.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1610.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 RCE1 "FACE-2, FACE2, hRCE1, RCE1A, RCE1B" ENSG00000173653 "Ras converting CAAX endopeptidase 1" Q9Y256 11 66842835-66846552 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA074124 Approved NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 27: Brain & Skin - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 10: Non-specific - Unknown function" "HPA074124: " "unprognostic (1.11e-1)" "unprognostic (7.23e-2)" "unprognostic (1.15e-1)" "unprognostic (8.16e-3)" "unprognostic (3.11e-1)" "unprognostic (6.40e-3)" "unprognostic (1.98e-3)" "unprognostic (7.69e-3)" "unprognostic (1.39e-1)" "unprognostic (9.14e-3)" "unprognostic (2.35e-3)" "unprognostic (5.31e-3)" "unprognostic (1.06e-1)" "unprognostic (4.48e-3)" "unprognostic (2.17e-2)" "unprognostic (1.04e-1)" "unprognostic (4.28e-2)" 10.1 10.9 14.9 7.2 15.1 20.9 9.3 17.9 18.2 10.7 13.7 13.3 10.1 8.4 5.9 19.9 8.9 8.6 7.3 14.7 14.9 25.7 7.9 8.9 9.9 14.0 14.1 10.8 15.5 9.5 13.9 11.8 14.2 12.0 8.2 10.0 12.6 6.1 4.4 19.9 12.4 5.9 13.5 12.0 12.0 13.5 15.5 9.5 7.0 4.2 6.1 11.9 12.9 14.6 22.7 24.5 14.7 13.8 9.0 7.8 32.3 11.6 11.2 17.7 15.8 46.6 47.2 17.2 21.8 11.1 29.3 39.6 17.1 17.4 10.2 20.7 19.3 15.5 17.0 18.0 31.7 20.3 22.0 12.6 32.7 19.9 17.6 13.7 14.6 23.5 21.7 26.0 9.0 42.8 28.2 38.3 43.5 43.1 24.0 22.9 11.0 34.1 19.5 12.0 18.3 16.5 16.8 22.3 74.1 14.3 26.2 16.3 9.7 24.2 18.7 26.4 18.5 14.6 15.2 19.6 16.4 20.8 18.4 23.1 21.1 14.6 17.1 24.0 15.6 15.3 14.7 22.1 18.9 12.0 11.8 17.8 7.2 14.3 21.5 29.1 6.7 17.8 14.9 15.1 17.9 18.2 14.7 14.9 14.0 14.1 14.2 13.5 15.5 14.6 12.5 0.0 4.8 4.2 16.9 31.2 26.6 46.2 14.2 9.2 16.4 20.6 1.8 10.0 20.3 16.5 29.2 54.6 24.9 12.4 3.9 24.3 10.1 11.3 12.5 12.2 10.7 10.7 7.7 27.4 65.0 12.0 11.7 17.1 8.2 13.3 8.2 3.0 22.8 3.3 6.2 16.0 26.4 8.9 15.1 20.2 6.8 13.3 14.2 3.7 12.9 6.4 9.2 6.0 4.0 30.0 18.0 6.4 14.5 19.6 23.2 7.4 8.9 18.0 13.1 5.6 32.1 9.7 25.7 17.1 24.9 58.6 19.1 10.3 16.2 23.9 REN ENSG00000143839 Renin P00797 1 204154819-204190324 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" "Aspartyl protease, Hydrolase, Protease" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 10 "kidney: 162.2" "Cell type enhanced" "Detected in some" "Early spermatids: 6.8;Late spermatids: 28.4;Paneth cells: 5.6;Smooth muscle cells: 10.7;Urothelial cells: 7.0" "Cancer enriched" "Detected in many" 8 "renal cancer: 39.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 1.0;BJ: 2.0;HMC-1: 2.6;SK-BR-3: 1.8" "Not detected" "Not detected" "Not detected" "Not detected" HPA005131 Approved "Secreted to blood" NA NA 692000 10000 "Cluster 7: Kidney - Transmembrane transport" "Cluster 3: HMC-1 - Innate immune response" "Cluster 33: Fibroblasts - ECM organization" "HPA005131: AB_1079174" "unprognostic (4.45e-2)" "unprognostic (3.35e-1)" "unprognostic (1.62e-1)" "unprognostic (8.58e-2)" "unprognostic (2.89e-1)" "unprognostic (1.23e-2)" "unprognostic (1.24e-1)" "unprognostic (1.13e-1)" "unprognostic (7.20e-3)" "unprognostic (1.37e-1)" "unprognostic (1.57e-1)" "prognostic unfavorable (6.45e-5)" "unprognostic (1.22e-1)" "unprognostic (1.70e-1)" "unprognostic (4.98e-2)" "unprognostic (6.49e-2)" 1.0 1.4 0.3 0.2 0.9 0.0 0.1 0.0 0.2 4.3 3.2 0.4 0.3 9.6 0.3 0.2 2.3 0.1 1.8 0.2 0.0 162.2 0.7 0.7 0.0 0.3 0.4 16.3 0.0 0.0 0.6 15.2 0.1 0.3 0.2 0.1 0.8 0.8 0.0 0.1 0.1 1.5 0.0 0.1 0.0 0.9 0.2 0.5 0.0 0.0 0.5 5.2 0.3 0.0 1.0 0.0 0.0 0.0 0.1 0.0 0.0 2.0 0.4 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.7 0.1 0.0 0.0 1.8 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.9 0.0 0.2 0.2 0.0 0.3 0.4 0.1 0.0 0.2 0.0 0.0 0.0 1.5 1.0 0.0 0.0 0.8 0.7 0.0 0.7 0.1 0.0 0.2 0.0 0.3 1.8 0.0 0.3 0.0 0.0 0.0 1.2 6.8 0.2 0.5 0.4 0.0 0.0 0.3 1.1 0.2 2.8 0.0 0.5 0.0 0.0 0.0 0.0 0.5 0.0 0.3 0.0 0.0 0.0 0.0 28.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 1.0 5.6 0.4 0.0 1.8 0.0 0.0 0.0 0.3 0.0 0.0 10.7 0.3 0.2 0.0 0.0 1.1 0.1 1.3 0.0 7.0 RHBDD1 DKFZp547E052 ENSG00000144468 "Rhomboid domain containing 1" Q8TEB9 2 226835581-226999215 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Apoptosis, Differentiation, Spermatogenesis" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 66.9;Microglial cells: 57.1;Oligodendrocyte precursor cells: 55.8;Oligodendrocytes: 109.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "U-698: 73.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA013972, HPA057125" Approved Supported "Endoplasmic reticulum" NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 57: B-cells - Immune response" "Endoplasmic reticulum" "HPA013972: AB_2178629, HPA057125: AB_2683343" "unprognostic (1.42e-1)" "unprognostic (5.37e-2)" "unprognostic (3.26e-1)" "unprognostic (5.23e-2)" "unprognostic (2.57e-1)" "unprognostic (2.91e-1)" "unprognostic (1.17e-2)" "unprognostic (2.07e-2)" "unprognostic (1.18e-1)" "unprognostic (9.40e-2)" "unprognostic (4.74e-3)" "unprognostic (4.97e-2)" "unprognostic (1.16e-1)" "unprognostic (1.79e-1)" "unprognostic (1.09e-1)" "unprognostic (9.77e-2)" "unprognostic (3.04e-2)" 10.3 8.9 11.2 13.6 20.9 11.9 11.5 12.2 13.6 11.6 1.8 11.5 10.3 13.6 12.5 11.5 12.9 10.9 10.3 8.8 15.2 12.0 15.1 9.9 16.1 15.6 15.0 13.6 13.9 16.5 4.4 9.9 17.1 13.1 11.2 7.4 9.6 13.3 8.9 8.8 11.8 14.3 15.7 14.2 11.4 17.4 16.8 37.5 15.6 8.6 16.9 11.5 7.0 22.8 10.7 9.3 9.9 15.1 28.6 28.8 0.0 24.1 20.9 12.6 14.6 8.3 18.7 10.1 19.8 25.2 18.0 11.9 0.1 26.8 23.9 25.1 9.9 15.3 5.9 6.7 31.5 15.2 8.0 25.6 38.2 23.8 51.4 14.3 9.8 26.7 41.7 25.6 13.4 18.9 27.8 8.5 0.0 12.2 10.3 12.0 0.1 14.9 10.3 13.3 9.7 7.3 13.6 5.1 18.8 17.6 14.1 18.9 13.1 5.6 12.2 22.0 7.5 28.8 14.9 73.9 17.8 19.6 16.2 10.4 13.7 12.8 7.3 20.0 11.8 22.1 11.0 8.9 17.2 24.5 12.6 10.6 3.3 11.8 13.8 21.1 16.2 10.8 11.2 20.9 12.2 13.6 8.8 15.2 15.6 15.0 17.1 15.7 16.8 22.8 6.6 12.8 6.4 66.9 28.4 5.2 8.5 7.2 8.0 8.0 7.6 4.2 16.6 4.3 8.1 11.0 16.7 7.6 9.3 6.6 3.9 7.0 16.7 8.3 8.6 6.8 1.8 15.2 28.4 9.3 4.1 9.3 8.2 7.8 8.2 22.7 3.3 14.0 5.2 11.8 41.5 6.1 6.1 8.2 4.4 24.4 5.6 7.6 12.4 57.1 6.2 6.3 9.2 55.8 109.0 8.3 1.9 6.8 48.8 13.2 6.8 3.4 7.1 6.3 0.0 5.6 6.6 15.2 9.5 7.3 5.5 5.6 8.6 25.7 5.7 8.9 RHBDD2 "NPD007, RHBDL7" ENSG00000005486 "Rhomboid domain containing 2" Q6NTF9 7 75842602-75888926 "Enzymes, Predicted membrane proteins, Transporters" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 380.1" "Cell type enhanced" "Detected in all" "Late spermatids: 300.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 398.8" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MCF7: 165.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045074, HPA051960" Uncertain Enhanced "Golgi apparatus" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 25: Spermatids - Spermatogenesis" "Golgi apparatus" "HPA045074: AB_10965705, HPA051960: AB_2681673" "unprognostic (2.75e-1)" "unprognostic (3.89e-2)" "prognostic unfavorable (3.31e-5)" "unprognostic (9.79e-2)" "prognostic unfavorable (1.81e-4)" "unprognostic (2.05e-2)" "unprognostic (1.18e-2)" "unprognostic (2.37e-3)" "unprognostic (1.55e-1)" "unprognostic (2.75e-1)" "unprognostic (5.11e-2)" "unprognostic (1.87e-2)" "prognostic favorable (8.68e-6)" "unprognostic (3.73e-1)" "unprognostic (6.53e-2)" "unprognostic (1.89e-1)" "unprognostic (1.03e-1)" 43.9 232.5 247.5 20.0 248.6 26.9 47.7 169.0 313.0 46.7 224.2 39.4 35.7 36.4 59.3 48.5 47.0 23.2 54.7 255.0 380.1 97.7 99.8 72.0 16.2 216.3 252.8 61.2 56.8 182.8 299.6 16.5 274.5 79.0 16.0 39.1 53.3 94.8 35.0 49.4 44.9 11.8 187.5 50.2 57.6 87.2 321.2 19.9 91.1 11.6 12.5 45.3 43.6 208.3 24.0 80.2 34.5 57.9 16.3 11.5 12.8 12.8 50.6 26.6 27.2 43.6 59.7 7.5 13.0 26.3 59.4 33.7 22.4 17.6 10.3 25.9 46.3 9.0 48.0 41.4 45.0 13.8 61.5 25.0 35.7 31.1 12.3 43.9 20.4 51.2 19.0 51.6 26.9 165.3 26.1 74.9 31.7 41.0 45.1 19.4 22.7 66.8 47.2 42.9 43.3 88.7 59.3 107.8 47.9 23.2 66.3 23.2 20.4 43.5 39.6 29.2 27.9 48.4 18.5 12.9 50.4 20.4 59.9 398.8 62.8 79.0 80.0 66.1 68.9 51.7 89.1 71.7 63.0 50.8 72.5 65.3 104.7 63.6 35.1 49.7 126.8 61.2 247.5 248.6 169.0 313.0 255.0 380.1 216.3 252.8 274.5 187.5 321.2 208.3 20.5 41.7 31.9 16.6 23.7 23.2 46.5 127.6 18.2 34.9 42.3 22.4 8.8 55.8 76.8 86.5 33.3 54.8 20.7 48.3 19.6 94.1 171.2 30.2 12.8 26.9 89.8 10.3 27.0 102.1 41.3 34.7 39.8 16.2 192.7 72.4 57.8 43.1 45.5 18.5 31.9 35.1 128.1 35.9 32.7 300.8 42.6 47.8 60.5 5.6 21.4 68.8 29.9 13.0 11.0 78.1 37.6 52.6 27.9 47.8 52.8 52.5 89.3 35.7 6.6 19.0 26.4 57.3 29.7 27.9 23.7 52.0 61.2 198.1 30.2 50.1 RHBDF1 "C16orf8, Dist1, EGFR-RS, FLJ2235, iRhom1" ENSG00000007384 "Rhomboid 5 homolog 1" Q96CC6 16 58059-76355 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Protein transport, Transport" "Growth factor binding" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 66.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA077399 Uncertain Vesicles NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 55: Plasma cells - Humoral immune response" Vesicles "HPA077399: " "unprognostic (2.62e-1)" "unprognostic (2.86e-2)" "unprognostic (4.76e-2)" "unprognostic (4.04e-2)" "unprognostic (1.51e-2)" "unprognostic (3.69e-2)" "unprognostic (5.60e-3)" "unprognostic (4.54e-3)" "unprognostic (4.51e-2)" "unprognostic (1.02e-1)" "unprognostic (7.81e-3)" "unprognostic (2.09e-1)" "prognostic unfavorable (2.49e-5)" "unprognostic (4.81e-2)" "unprognostic (1.87e-1)" "unprognostic (8.36e-2)" "unprognostic (4.22e-2)" 41.9 11.5 14.5 6.0 14.4 0.5 44.3 13.5 19.5 65.1 13.3 38.2 7.5 38.1 13.0 47.0 36.4 22.1 51.7 14.3 13.5 24.7 13.2 58.5 5.5 14.5 14.4 55.6 23.4 8.9 13.3 27.5 13.9 61.2 7.1 2.5 38.3 16.5 34.1 46.1 24.8 10.5 14.0 19.3 28.5 8.0 14.7 1.2 33.4 16.9 5.5 44.6 61.4 13.5 10.8 17.3 9.7 22.5 37.2 45.7 31.8 29.1 53.8 20.1 19.1 23.5 36.9 0.6 11.8 31.1 10.2 33.6 4.8 19.6 3.4 0.5 5.3 0.4 18.8 6.6 41.4 0.3 18.3 38.3 20.3 51.9 8.6 35.5 31.4 0.1 4.1 0.4 32.2 60.6 0.1 3.5 8.8 22.7 14.5 0.3 11.5 0.9 22.7 11.0 0.3 2.4 8.4 31.8 18.7 11.9 49.1 3.8 32.6 31.5 21.9 24.8 8.1 0.2 0.7 0.3 22.0 0.6 50.7 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.5 14.4 13.5 19.5 14.3 13.5 14.5 14.4 13.9 14.0 14.7 13.5 10.5 19.2 6.2 9.1 0.3 6.8 9.9 15.2 5.2 0.8 17.8 13.5 9.9 22.8 15.8 9.2 66.7 19.0 0.3 21.9 0.0 21.4 1.1 3.8 9.9 9.2 0.0 0.0 1.7 8.0 16.3 20.6 15.8 11.2 0.0 8.7 8.2 3.0 2.2 0.0 0.6 9.8 18.3 0.6 5.1 1.1 19.6 0.4 16.0 5.6 0.0 6.9 0.0 16.6 0.7 28.4 13.6 13.9 0.2 25.8 2.1 2.3 5.3 4.9 13.1 10.8 22.3 0.3 1.9 6.6 5.5 30.6 0.8 16.4 3.8 17.9 RHBDF2 "FLJ22341, iRhom2, RHBDL5, RHBDL6, TOC, TOCG" ENSG00000129667 "Rhomboid 5 homolog 2" Q6PJF5 17 76470891-76501790 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Protein transport, Transport" "Growth factor binding" "Disease variant, Palmoplantar keratoderma" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "B-cells: 58.4;Kupffer cells: 57.3;NK-cells: 64.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "RPMI-8226: 75.3" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA018080 Uncertain NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 25: RPMI-8226 - Immune response" "Cluster 57: B-cells - Immune response" "HPA018080: AB_2178634" "unprognostic (1.19e-1)" "unprognostic (8.71e-2)" "unprognostic (1.59e-2)" "unprognostic (5.11e-3)" "unprognostic (4.33e-2)" "unprognostic (1.63e-1)" "unprognostic (2.63e-3)" "unprognostic (9.79e-3)" "unprognostic (2.55e-1)" "unprognostic (1.72e-1)" "unprognostic (4.49e-2)" "unprognostic (1.38e-1)" "prognostic unfavorable (3.96e-11)" "unprognostic (5.24e-2)" "unprognostic (2.14e-2)" "unprognostic (1.61e-2)" "unprognostic (1.14e-1)" 18.3 10.1 9.4 31.2 8.6 29.7 13.6 11.7 11.0 8.8 11.6 9.0 6.5 7.4 1.6 23.9 10.1 10.3 10.3 9.7 12.1 10.9 6.3 24.8 27.6 26.6 17.2 8.0 19.5 3.1 5.3 9.7 22.4 9.1 4.4 2.9 11.6 2.6 13.5 29.1 26.6 6.4 20.9 42.2 10.5 3.0 30.0 6.5 12.3 3.1 21.3 11.0 15.7 28.8 38.3 43.3 1.3 10.7 0.4 1.1 30.1 8.6 26.9 6.7 9.1 13.3 45.0 41.5 28.6 10.9 39.0 29.9 7.3 40.8 6.2 7.1 13.6 2.8 3.5 21.8 25.6 1.8 5.9 4.5 20.2 18.1 20.7 15.4 20.3 5.9 4.3 18.3 4.6 30.7 4.3 4.7 6.7 25.7 26.1 10.3 0.4 75.3 17.8 14.0 9.2 12.6 9.9 28.7 38.7 8.5 24.7 11.4 32.4 0.6 14.4 0.7 11.0 44.3 22.6 33.7 24.3 11.2 27.1 6.3 13.4 4.3 8.0 13.1 5.5 12.7 2.1 5.8 6.5 7.4 1.5 3.6 10.2 4.9 12.2 10.0 1.1 8.8 9.4 8.6 11.7 11.0 9.7 12.1 26.6 17.2 22.4 20.9 30.0 28.8 22.3 6.4 6.9 2.3 58.4 17.6 15.3 35.0 8.0 4.2 4.7 5.5 3.3 18.6 19.2 3.7 2.1 1.0 47.1 2.0 0.0 21.3 0.5 4.2 0.8 15.3 1.8 1.3 0.6 9.8 2.2 4.7 7.7 6.6 0.0 15.4 7.9 3.4 37.6 0.0 0.5 4.1 6.1 57.3 42.7 0.7 0.9 48.8 10.6 38.4 40.1 1.1 64.9 1.0 0.1 14.2 4.8 0.4 36.5 20.4 1.9 1.8 16.2 1.4 6.6 3.6 3.2 0.7 7.1 9.9 29.3 1.6 22.3 2.8 7.8 20.4 RHBDL1 "RHBDL, RRP" ENSG00000103269 "Rhomboid like 1" O75783 16 675671-678268 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 17.7" "Cell type enhanced" "Detected in many" "Bipolar cells: 17.6;Excitatory neurons: 30.1;Inhibitory neurons: 27.1;Ionocytes: 18.3;Rod photoreceptor cells: 31.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HeLa: 9.8;MCF7: 9.2;U-266/70: 10.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030359, HPA030360, HPA046593" Uncertain Approved Nucleoplasm No No "Cluster 48: NK-cells - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 29: U-266 - Adaptive immune response" "Cluster 9: Photoreceptor cells - Phototransduction" Nucleoplasm "HPA030359: AB_2673445, HPA030360: AB_2673446, HPA046593: AB_2679711" "prognostic favorable (8.12e-4)" "unprognostic (1.70e-1)" "unprognostic (7.38e-2)" "unprognostic (4.45e-1)" "unprognostic (2.07e-1)" "unprognostic (1.58e-2)" "unprognostic (3.27e-2)" "unprognostic (1.94e-1)" "unprognostic (2.78e-1)" "unprognostic (6.60e-3)" "unprognostic (2.74e-2)" "unprognostic (3.97e-2)" "unprognostic (5.63e-3)" "unprognostic (5.89e-2)" "unprognostic (1.27e-1)" "unprognostic (8.30e-3)" "unprognostic (1.49e-2)" 0.8 5.0 9.2 0.4 9.7 1.0 1.0 9.1 17.7 2.0 0.0 2.2 2.4 1.0 0.6 1.2 1.6 0.4 2.4 7.9 6.1 4.1 2.0 1.1 0.4 5.5 4.8 2.1 2.6 0.6 8.3 0.3 4.9 2.7 0.3 2.1 2.4 0.9 0.5 2.6 2.5 0.2 3.2 0.9 2.7 4.2 7.4 1.4 0.9 0.0 0.1 1.5 1.5 7.7 1.7 2.1 1.2 1.8 0.9 2.3 6.1 0.7 1.1 0.4 0.1 4.4 1.2 0.6 1.4 0.4 0.2 1.1 0.1 0.3 0.0 1.5 7.7 0.8 9.8 1.8 0.8 1.6 1.1 1.6 2.8 0.3 0.0 0.9 0.1 2.8 1.3 1.2 0.1 9.2 0.4 4.4 1.1 2.3 0.6 7.6 1.1 1.6 0.1 1.5 1.5 2.0 0.9 0.4 2.2 0.7 3.2 4.5 0.5 2.5 2.2 0.8 0.6 10.5 1.5 2.2 0.9 2.9 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.8 0.0 0.0 0.1 0.1 0.0 0.0 0.4 0.0 0.0 0.3 0.1 9.2 9.7 9.1 17.7 7.9 6.1 5.5 4.8 4.9 3.2 7.4 7.7 0.6 0.0 0.0 15.3 2.8 2.2 3.8 10.3 12.5 17.6 2.5 4.2 0.9 0.0 2.4 0.0 12.5 0.2 0.3 2.7 0.0 0.7 2.7 1.4 1.1 0.3 2.4 0.0 30.1 0.5 0.2 1.1 3.1 1.0 0.0 1.9 0.4 0.7 0.3 15.2 27.1 6.1 18.3 0.9 1.2 1.4 1.5 0.4 0.0 1.9 0.2 2.9 0.0 10.6 4.1 1.4 3.8 2.6 0.9 1.6 17.3 9.9 10.8 31.8 0.0 0.4 1.2 1.5 1.7 1.4 1.8 0.3 0.6 3.0 5.5 2.8 RHBDL2 FLJ20435 ENSG00000158315 "Rhomboid like 2" Q9NX52 1 38885807-38941830 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 24.4" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 74.6;Club cells: 44.8;Distal enterocytes: 52.2;Ionocytes: 46.8;Oligodendrocytes: 53.9;Pancreatic endocrine cells: 53.0;Urothelial cells: 49.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "A-431: 12.7;CAPAN-2: 41.7;HaCaT: 21.7;RT4: 40.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA043807 Approved NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 27: Brain & Skin - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "HPA043807: AB_10961118" "unprognostic (3.34e-2)" "unprognostic (2.96e-1)" "unprognostic (4.57e-2)" "unprognostic (2.56e-1)" "unprognostic (7.26e-3)" "unprognostic (2.19e-2)" "unprognostic (1.04e-3)" "unprognostic (5.81e-2)" "unprognostic (2.36e-1)" "unprognostic (2.87e-1)" "unprognostic (4.07e-3)" "unprognostic (1.23e-1)" "unprognostic (7.47e-9)" "unprognostic (1.11e-2)" "unprognostic (2.46e-1)" "unprognostic (4.12e-2)" "unprognostic (4.20e-2)" 2.2 0.4 4.1 1.7 8.8 0.4 2.0 5.6 7.1 4.3 0.3 18.0 1.3 0.6 0.2 24.4 1.1 3.4 7.7 4.0 4.9 0.9 0.4 1.0 0.8 10.0 9.5 0.3 0.6 0.3 1.3 1.1 7.3 1.8 18.0 1.1 7.8 0.5 0.5 16.6 0.8 1.1 4.1 0.4 15.7 7.3 7.4 0.7 0.7 0.0 7.1 9.7 12.8 11.4 12.7 4.3 0.4 0.2 0.2 1.2 1.2 0.7 0.1 0.9 0.1 0.9 41.7 0.3 3.0 6.3 4.2 21.7 0.0 7.1 0.6 0.3 0.2 0.2 2.9 2.5 0.5 0.1 0.5 0.9 1.0 6.0 0.1 4.0 1.0 0.4 0.0 0.4 0.9 0.0 0.1 0.3 0.2 1.3 1.2 0.2 0.2 0.0 0.0 40.4 0.4 0.3 5.0 11.4 0.4 0.6 5.6 0.4 0.9 4.4 0.5 0.3 0.3 0.4 0.5 0.5 4.1 0.8 0.2 1.5 0.6 0.4 0.2 0.4 0.1 0.7 0.2 0.1 0.7 0.3 0.2 0.2 1.7 0.3 0.2 0.7 0.3 0.3 4.1 8.8 5.6 7.1 4.0 4.9 10.0 9.5 7.3 4.1 7.4 11.4 1.3 0.0 0.5 11.1 0.7 17.7 8.0 74.6 5.2 2.7 3.9 2.4 0.4 5.7 44.8 3.7 0.0 0.4 0.2 52.2 0.0 12.4 3.9 4.7 3.4 1.4 2.4 0.0 19.0 15.8 0.3 2.1 27.5 8.4 4.5 1.6 1.8 0.0 0.2 1.7 21.9 17.3 46.8 0.0 2.7 1.0 0.6 0.4 1.8 4.7 0.6 1.3 0.0 10.6 53.9 53.0 22.3 0.0 0.2 13.4 0.2 0.3 33.2 1.8 6.6 1.2 4.0 0.3 0.1 19.0 28.4 0.7 0.5 0.2 30.2 49.9 RHBDL3 "RHBDL4, VRHO" ENSG00000141314 "Rhomboid like 3" P58872 17 32265832-32324659 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 23.0;heart muscle: 13.8;retina: 26.1" "Cell type enhanced" "Detected in some" "Astrocytes: 41.8;Excitatory neurons: 46.8;Horizontal cells: 102.6;Oligodendrocyte precursor cells: 75.9;Rod photoreceptor cells: 34.2" "Cancer enriched" "Detected in some" 4 "glioma: 4.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 4.6;AF22: 4.7;AN3-CA: 3.8;GAMG: 5.5;HDLM-2: 6.0;NTERA-2: 6.5;U-2 OS: 4.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA059607 Uncertain NA NA "Cluster 58: Brain - Synaptic function" "Cluster 44: HDLM-2 - Immune response" "Cluster 62: Horizontal cells - Visual perception" "HPA059607: AB_2684081" "unprognostic (7.70e-2)" "unprognostic (3.71e-2)" "unprognostic (2.36e-2)" "unprognostic (6.95e-2)" "unprognostic (2.91e-1)" "unprognostic (2.83e-2)" "unprognostic (2.22e-1)" "unprognostic (1.93e-1)" "unprognostic (1.85e-3)" "unprognostic (1.13e-1)" "unprognostic (1.82e-3)" "unprognostic (1.75e-2)" "unprognostic (4.19e-2)" "unprognostic (2.18e-3)" "unprognostic (2.11e-1)" "unprognostic (1.23e-1)" "unprognostic (8.87e-2)" 0.4 5.1 9.4 0.4 10.6 0.1 0.4 14.1 23.0 2.2 3.4 0.8 0.2 1.6 0.7 0.5 2.3 0.2 13.8 13.6 9.6 0.6 0.0 0.3 0.1 14.2 19.0 2.2 0.5 0.8 2.9 0.2 15.9 1.6 0.5 26.1 0.3 3.0 0.1 0.3 0.4 0.7 12.1 0.1 0.7 2.0 11.6 0.2 0.3 0.1 0.2 2.3 1.8 14.8 0.0 4.6 4.7 3.8 0.7 0.0 0.1 0.2 0.5 1.4 1.7 0.0 0.0 0.0 0.2 0.5 5.5 0.0 1.2 0.0 0.3 6.0 1.5 0.8 3.1 0.2 0.0 0.0 0.1 0.0 0.0 1.2 0.0 0.2 0.0 0.3 0.5 0.0 0.3 0.1 0.1 0.0 6.5 0.0 0.0 0.8 0.0 0.0 0.0 2.6 0.1 1.3 0.6 0.1 0.1 1.5 0.3 0.0 0.0 0.0 4.4 0.2 2.2 0.0 0.0 0.0 0.2 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.4 10.6 14.1 23.0 13.6 9.6 14.2 19.0 15.9 12.1 11.6 14.8 0.6 0.0 0.0 41.8 0.0 0.4 0.5 0.0 0.0 12.1 0.8 0.6 7.4 0.0 0.0 0.0 6.2 1.5 0.1 0.0 0.0 0.1 3.2 0.3 0.2 0.7 0.0 0.0 46.8 0.0 0.0 0.5 0.0 0.1 0.0 0.4 0.4 0.0 0.4 102.6 15.2 0.4 0.0 0.3 0.3 2.4 0.9 0.1 0.0 4.7 0.0 7.4 0.0 75.9 4.8 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 34.2 0.0 0.1 0.5 0.1 1.2 0.0 0.1 0.5 0.1 0.0 0.0 0.6 RNPEP APB ENSG00000176393 "Arginyl aminopeptidase" Q9H4A4 1 201982372-202006147 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 201.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 4 "dendritic cells: 19.8;granulocytes: 22.9;monocytes: 29.9" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036074, HPA036075, HPA061487" Approved Approved "Golgi apparatus" "Secreted - unknown location" NA NA 7800000 "Cluster 52: Eosinophils - Transcription" "Cluster 37: Intestine - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 45: Enterocytes - Digestion" "Golgi apparatus" "HPA036074: AB_2674926, HPA036075: AB_10672999, HPA061487: AB_2684537" "unprognostic (8.57e-2)" "unprognostic (3.43e-2)" "unprognostic (2.81e-1)" "unprognostic (5.45e-2)" "unprognostic (2.68e-1)" "unprognostic (1.74e-2)" "unprognostic (1.95e-2)" "unprognostic (2.87e-2)" "unprognostic (1.93e-3)" "unprognostic (1.80e-1)" "unprognostic (1.07e-1)" "unprognostic (1.28e-1)" "unprognostic (3.50e-3)" "unprognostic (1.91e-1)" "unprognostic (6.00e-2)" "unprognostic (1.97e-2)" "unprognostic (1.68e-1)" 25.2 31.1 8.0 22.8 8.3 25.2 25.8 8.1 8.5 26.7 16.1 53.6 68.5 25.6 39.0 53.8 40.6 22.3 14.7 8.5 8.7 25.9 32.4 30.5 22.1 9.9 9.1 23.4 34.1 25.4 13.3 27.5 9.1 25.9 57.0 4.2 38.3 27.6 18.8 37.0 58.1 28.1 9.1 33.4 28.5 17.9 10.6 21.7 33.2 12.7 26.5 23.3 28.8 11.8 66.2 71.0 40.8 62.7 65.1 61.3 102.1 49.5 95.6 60.9 67.6 51.8 83.1 14.3 61.8 87.8 38.0 117.4 52.5 97.2 42.4 39.1 67.6 35.5 32.5 48.7 55.1 92.3 121.3 55.9 97.9 54.1 62.0 74.7 110.6 34.8 82.5 21.6 62.1 61.0 12.8 40.2 58.4 105.4 34.4 48.3 57.5 101.6 128.7 61.2 46.9 39.9 122.2 155.9 52.1 78.9 116.6 52.4 79.9 28.9 38.0 28.7 61.3 45.3 39.6 12.9 27.8 77.3 58.1 22.9 14.9 22.1 3.0 25.9 4.1 2.5 3.2 3.4 19.8 4.6 2.8 3.2 11.0 2.9 29.9 7.2 5.4 4.0 8.0 8.3 8.1 8.5 8.5 8.7 9.9 9.1 9.1 9.1 10.6 11.8 26.7 9.6 21.5 8.5 19.7 28.8 40.5 31.2 40.5 15.5 32.8 33.1 12.2 38.6 26.7 25.8 10.4 116.6 21.4 136.6 19.6 71.1 5.4 35.9 17.7 26.1 44.9 19.0 12.7 51.2 91.1 26.1 45.3 21.5 15.2 23.2 27.1 51.4 103.7 11.8 11.1 71.9 14.2 81.0 39.4 4.9 25.4 72.9 24.9 15.0 86.7 12.6 17.5 5.5 8.1 47.8 83.4 23.0 23.6 25.0 201.7 65.8 39.1 8.0 26.3 11.4 28.2 22.7 9.5 53.6 21.6 87.6 17.7 33.2 86.6 34.8 RNPEPL1 ENSG00000142327 "Arginyl aminopeptidase like 1" Q9HAU8 2 240565804-240581372 "Enzymes, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 138.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036772, HPA036773" Uncertain Supported "Nucleoplasm,Nuclear bodies" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 25: RPMI-8226 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "Nuclear bodies" "HPA036772: AB_10670848, HPA036773: " "unprognostic (3.92e-2)" "unprognostic (7.28e-2)" "unprognostic (1.20e-2)" "unprognostic (2.39e-1)" "unprognostic (5.24e-3)" "prognostic favorable (7.43e-4)" "prognostic unfavorable (5.06e-4)" "unprognostic (3.72e-3)" "unprognostic (9.10e-2)" "unprognostic (1.66e-3)" "unprognostic (3.10e-1)" "unprognostic (1.71e-1)" "unprognostic (1.98e-2)" "unprognostic (5.33e-2)" "unprognostic (1.57e-1)" "unprognostic (5.31e-2)" "unprognostic (9.86e-2)" 40.3 31.4 29.1 14.1 29.6 21.7 32.0 29.0 38.7 15.6 27.0 39.6 20.2 16.8 5.6 52.4 17.0 12.1 79.4 27.9 27.8 42.7 50.6 35.9 23.8 31.5 30.0 12.0 64.2 10.9 9.1 10.6 30.3 34.7 9.5 0.8 28.9 13.1 63.7 35.3 39.8 9.4 31.0 56.4 48.4 9.9 31.4 15.9 19.2 17.1 12.1 34.1 23.2 31.1 13.7 22.4 4.9 13.2 17.6 18.1 16.6 8.6 21.1 9.5 11.6 6.3 39.3 3.9 4.3 21.8 13.3 14.6 5.5 16.1 0.9 23.9 7.7 9.0 7.3 37.2 44.1 5.9 15.5 21.6 25.5 4.9 9.6 15.1 32.8 15.2 6.8 25.7 6.5 19.3 7.5 22.4 6.5 26.5 9.0 15.5 7.4 33.3 39.3 18.5 4.6 9.8 5.8 19.7 39.9 5.6 13.9 26.8 22.7 10.2 10.4 14.4 10.0 24.1 3.9 4.8 20.9 16.6 15.7 9.2 11.2 30.5 14.8 9.9 12.7 8.2 11.3 13.4 8.2 8.7 6.4 9.5 20.0 10.7 10.1 9.5 14.7 7.9 29.1 29.6 29.0 38.7 27.9 27.8 31.5 30.0 30.3 31.0 31.4 31.1 27.9 22.4 25.7 10.4 27.8 7.8 15.0 8.4 2.8 6.4 18.8 9.1 35.6 24.3 12.9 12.9 0.0 7.1 80.4 138.9 17.6 24.6 3.1 12.1 11.0 22.7 26.4 22.3 9.5 49.6 6.8 12.3 104.5 27.4 34.2 31.8 30.0 42.2 43.8 3.3 8.6 58.7 8.2 74.3 21.0 5.9 8.7 47.1 23.2 9.4 52.0 15.9 79.3 5.5 10.3 65.0 70.0 13.5 20.5 20.2 77.1 35.6 7.2 6.9 13.1 14.8 16.4 1.3 8.2 13.0 9.2 5.1 47.9 17.4 60.5 23.0 SCPEP1 RISC ENSG00000121064 "Serine carboxypeptidase 1" Q9HB40 17 56978129-57006768 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 300.9" "Cell type enhanced" "Detected in all" "Basal respiratory cells: 456.2;Club cells: 304.9;Respiratory ciliated cells: 397.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "eosinophil: 319.0" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "ASC diff: 389.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039102, HPA057200" Enhanced Approved "Golgi apparatus" "Secreted to blood" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Golgi apparatus" "HPA039102: AB_10673605, HPA057200: AB_2683365" "unprognostic (5.83e-3)" "unprognostic (7.43e-3)" "unprognostic (4.47e-2)" "unprognostic (2.96e-1)" "unprognostic (9.26e-2)" "unprognostic (1.43e-2)" "prognostic unfavorable (1.96e-5)" "unprognostic (1.00e-3)" "unprognostic (1.68e-1)" "unprognostic (1.70e-1)" "unprognostic (3.56e-3)" "unprognostic (1.40e-1)" "unprognostic (3.25e-1)" "unprognostic (7.28e-2)" "unprognostic (8.89e-2)" "unprognostic (8.33e-2)" "unprognostic (1.68e-1)" 64.1 121.5 25.7 32.6 26.4 75.8 91.0 27.3 42.9 69.8 34.5 46.9 31.4 37.5 73.1 54.8 48.5 71.2 60.1 27.2 30.9 88.6 32.0 95.1 48.7 30.1 29.5 53.6 17.0 300.9 28.7 20.8 30.6 61.6 33.7 8.1 90.0 102.9 15.8 46.3 40.3 60.9 28.7 44.8 54.2 14.3 28.4 14.6 135.1 32.5 60.6 71.1 51.1 33.6 48.3 20.9 49.4 41.4 389.3 85.6 26.0 23.3 119.6 41.9 77.8 13.7 33.3 63.3 126.4 55.9 65.8 44.0 22.0 105.4 46.8 82.0 36.1 19.8 28.2 8.7 89.1 39.1 190.1 103.7 45.0 52.0 43.0 37.5 72.3 24.3 5.1 257.9 59.1 20.3 19.9 100.4 20.4 15.2 39.3 24.2 53.8 41.4 9.3 143.7 13.8 33.8 56.3 45.6 33.3 57.1 19.1 104.1 34.1 118.3 29.9 68.8 26.5 250.5 187.2 35.9 88.1 28.5 34.4 2.1 228.5 319.0 11.8 137.1 8.0 56.0 8.2 8.3 105.7 55.1 11.3 12.3 34.8 23.7 141.0 18.0 10.2 118.7 25.7 26.4 27.3 42.9 27.2 30.9 30.1 29.5 30.6 28.7 28.4 33.6 48.8 44.8 61.8 25.1 52.7 23.7 208.6 456.2 37.5 12.7 52.4 110.7 32.5 10.0 304.9 95.6 16.7 9.9 20.5 2.0 19.6 22.2 1.0 51.5 24.5 27.1 24.4 21.2 37.2 6.8 19.4 115.4 4.6 13.6 8.2 4.3 62.8 15.7 160.5 10.1 24.9 5.0 126.1 135.0 33.7 3.4 64.3 110.2 24.9 20.6 142.2 18.9 25.7 21.1 20.7 4.8 1.6 68.1 39.0 74.1 62.4 29.7 397.8 17.0 52.6 28.1 63.2 4.4 12.3 38.1 19.9 11.1 18.8 67.1 8.0 122.6 SCRN1 KIAA0193 ENSG00000136193 "Secernin 1" Q12765 7 29920104-29990289 "Enzymes, Predicted intracellular proteins" Exocytosis "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 159.0" "Cell type enhanced" "Detected in many" "Muller glia cells: 80.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "WM-115: 326.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024517 Enhanced Approved Cytosol No No 160000 "Cluster 51: Monocytes - Innate immune response" "Cluster 77: Retina - Visual perception" "Cluster 17: WM-115 - Nervous system development" "Cluster 5: Muller glia cells - Visual perception" Cytosol "HPA024517: AB_2184811" "prognostic unfavorable (8.32e-4)" "prognostic unfavorable (8.46e-4)" "unprognostic (1.45e-1)" "prognostic unfavorable (4.00e-5)" "unprognostic (1.87e-2)" "unprognostic (2.43e-1)" "unprognostic (1.13e-3)" "unprognostic (1.10e-1)" "unprognostic (2.29e-1)" "prognostic unfavorable (7.27e-4)" "unprognostic (1.09e-2)" "unprognostic (1.02e-1)" "prognostic favorable (1.15e-5)" "unprognostic (2.57e-2)" "unprognostic (2.10e-1)" "unprognostic (2.23e-1)" "prognostic unfavorable (2.60e-4)" 13.9 27.9 112.4 13.1 118.9 8.1 14.3 128.2 117.9 22.2 52.2 27.5 6.5 27.4 16.2 19.0 26.0 16.5 19.8 112.5 129.0 23.7 2.6 16.4 14.3 112.5 159.0 32.4 36.7 54.5 34.0 15.8 115.5 27.9 10.4 102.5 18.0 37.2 2.4 11.1 15.8 34.3 116.1 10.8 19.3 23.0 122.5 28.9 13.5 11.0 21.6 22.0 17.8 127.1 106.3 75.0 119.9 48.6 83.1 126.9 0.5 97.0 128.8 102.5 110.0 87.1 81.8 13.0 83.7 124.7 227.3 46.7 137.7 41.2 148.9 0.6 29.0 43.8 49.7 56.6 105.9 0.3 0.5 106.5 58.1 93.5 49.6 139.4 95.9 28.0 0.5 33.3 146.6 59.5 15.5 0.1 109.4 0.2 79.6 0.3 127.7 1.1 71.7 51.5 43.7 103.1 99.9 64.1 112.5 149.7 86.3 6.9 106.7 132.2 113.3 1.7 123.7 10.8 177.0 1.1 62.4 0.5 326.5 3.7 3.4 10.3 0.9 14.1 10.7 14.0 0.2 1.0 10.9 7.6 0.7 1.4 0.5 7.1 25.4 10.8 0.0 3.5 112.4 118.9 128.2 117.9 112.5 129.0 112.5 159.0 115.5 116.1 122.5 127.1 5.9 28.9 14.1 42.7 15.4 3.1 12.6 14.0 14.2 66.9 7.6 5.2 15.8 20.0 22.3 33.1 45.9 0.4 16.2 1.1 15.6 24.1 61.1 7.3 11.9 10.9 12.1 2.5 52.0 25.1 1.9 17.2 5.6 6.7 8.2 22.9 1.8 0.3 5.4 69.0 51.4 0.7 14.2 8.8 13.9 68.1 13.7 11.1 7.2 16.9 11.5 80.8 12.3 31.2 35.6 21.2 17.3 21.1 12.5 17.4 0.1 2.8 29.2 41.1 6.6 9.6 11.9 3.1 11.0 5.1 1.7 1.0 2.8 8.5 1.2 22.3 SCRN2 ENSG00000141295 "Secernin 2" Q96FV2 17 47837692-47841289 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 149.7;Proximal tubular cells: 332.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022934, HPA023434" Enhanced Supported "Nucleoplasm,Golgi apparatus" NA NA 370000 "Cluster 44: Non-specific - Transcription" "Cluster 7: Kidney - Transmembrane transport" "Cluster 25: RPMI-8226 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "Golgi apparatus" "HPA022934: AB_1856638, HPA023434: AB_1856639" "unprognostic (2.35e-2)" "unprognostic (1.42e-2)" "unprognostic (2.86e-1)" "unprognostic (6.14e-2)" "unprognostic (2.46e-2)" "unprognostic (1.73e-1)" "prognostic favorable (3.86e-4)" "unprognostic (4.63e-2)" "unprognostic (3.25e-2)" "unprognostic (5.77e-2)" "unprognostic (1.28e-3)" "unprognostic (8.72e-2)" "unprognostic (3.43e-2)" "unprognostic (5.28e-3)" "unprognostic (1.64e-1)" "unprognostic (1.20e-1)" "prognostic favorable (5.83e-4)" 81.2 22.9 18.9 11.1 19.4 13.4 48.9 18.8 22.3 28.2 22.0 23.8 43.8 24.5 11.5 19.2 26.5 12.0 31.9 18.5 20.6 68.6 37.2 17.4 12.9 19.9 19.6 25.4 26.4 25.4 31.5 12.9 18.8 28.5 10.4 6.5 33.8 19.7 38.1 22.1 36.7 10.2 20.1 34.0 21.5 10.6 19.4 12.0 39.9 25.0 10.1 22.2 23.3 20.1 28.0 43.8 12.1 11.0 33.7 25.7 36.6 13.7 27.6 20.6 21.0 32.5 33.2 15.3 27.5 7.1 11.0 14.7 3.9 24.6 6.9 37.6 29.7 15.5 33.8 29.2 12.0 7.9 12.7 25.7 18.1 12.8 9.8 31.5 23.5 35.6 5.4 18.2 28.9 25.4 24.6 12.8 6.0 12.1 17.5 32.7 9.0 62.4 16.9 12.9 8.9 37.6 8.0 17.3 17.8 8.3 37.9 14.5 10.7 18.2 20.8 5.6 6.6 70.2 9.8 7.7 52.1 13.2 4.2 24.5 19.9 43.4 24.6 21.1 24.1 24.8 20.4 24.2 25.7 25.3 31.7 17.8 5.4 29.3 10.8 30.1 23.0 16.5 18.9 19.4 18.8 22.3 18.5 20.6 19.9 19.6 18.8 20.1 19.4 20.1 21.9 38.5 29.9 15.0 18.7 15.7 31.5 41.8 20.5 12.0 24.5 25.7 19.3 15.7 35.9 16.5 10.4 43.1 12.4 33.2 74.3 27.7 3.9 16.9 10.0 24.6 22.3 7.2 12.4 61.0 9.3 25.7 17.3 12.4 16.5 22.1 24.3 26.7 22.7 20.2 10.5 33.6 48.8 11.1 13.7 2.8 33.2 12.8 42.7 7.5 13.9 28.8 26.8 11.1 6.0 33.3 36.5 16.6 30.9 14.1 149.7 332.7 40.9 16.8 6.6 19.1 16.0 5.2 16.7 21.9 11.5 33.8 21.6 23.9 40.7 27.0 SCRN3 FLJ23142 ENSG00000144306 "Secernin 3" Q0VDG4 2 174395730-174429575 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034689, HPA034690" Approved Approved Vesicles,Cytosol NA NA 27000 "Cluster 1: Neutrophils - Mixed function" "Cluster 8: Non-specific - Mitochondria" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Vesicles, Cytosol" "HPA034689: AB_2674282, HPA034690: AB_10670574" "unprognostic (5.39e-3)" "unprognostic (4.58e-2)" "unprognostic (2.06e-2)" "unprognostic (3.58e-1)" "unprognostic (1.91e-1)" "unprognostic (1.89e-1)" "unprognostic (9.89e-2)" "unprognostic (1.57e-1)" "unprognostic (5.14e-2)" "unprognostic (5.85e-2)" "unprognostic (8.81e-2)" "unprognostic (1.30e-1)" "unprognostic (6.62e-3)" "unprognostic (1.75e-1)" "unprognostic (1.31e-1)" "unprognostic (5.57e-2)" "unprognostic (1.57e-1)" 16.4 16.4 11.8 9.9 14.4 5.2 13.5 14.7 16.0 9.5 7.0 12.9 18.5 11.9 11.4 16.2 10.4 11.2 26.0 10.8 13.6 20.2 22.0 12.2 11.4 14.6 13.4 13.2 14.7 27.7 14.0 13.1 13.6 15.2 13.2 22.8 11.0 12.5 40.5 13.8 14.3 14.0 12.9 11.8 12.4 10.6 14.1 12.4 20.3 35.8 12.1 10.4 8.3 18.5 15.9 9.7 25.8 22.8 18.8 21.1 13.7 24.1 19.0 18.2 22.0 9.6 11.4 3.0 15.6 24.2 14.0 15.5 19.3 21.1 23.9 34.8 17.8 29.7 21.1 7.5 27.8 22.8 15.0 23.5 25.4 34.4 24.5 20.4 21.8 16.7 20.2 11.1 25.0 18.0 18.9 22.2 12.0 35.4 41.0 9.3 25.7 17.5 21.2 16.5 16.0 44.5 16.6 16.2 30.7 26.4 21.8 21.7 15.7 20.9 10.9 25.6 21.0 29.4 32.8 0.5 22.9 11.2 21.8 7.2 5.2 2.2 4.8 3.3 3.4 8.6 5.1 4.6 5.1 11.0 7.8 6.3 20.0 6.9 4.3 8.0 5.6 2.6 11.8 14.4 14.7 16.0 10.8 13.6 14.6 13.4 13.6 12.9 14.1 18.5 7.8 9.6 15.6 18.6 7.0 3.6 12.1 23.7 12.5 12.8 7.9 6.3 22.8 4.3 12.5 9.2 10.4 10.7 3.8 8.4 13.7 9.1 5.1 9.4 8.3 6.0 6.0 11.6 21.0 9.8 6.3 6.9 11.2 5.4 8.8 9.5 8.6 8.7 9.3 18.5 26.3 7.3 20.3 5.8 2.2 4.0 4.7 6.2 3.6 6.5 6.1 22.6 7.2 27.6 25.7 12.2 4.0 6.8 10.3 5.4 9.9 12.5 13.6 15.0 0.0 8.2 7.1 18.9 7.1 20.4 4.8 6.8 5.8 13.0 6.4 9.7 SEC11A "SEC11L1, sid2895, SPC18, SPCS4A" ENSG00000140612 "SEC11 homolog A, signal peptidase complex subunit" P67812 15 84669538-84716460 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA047533 Approved "Nuclear membrane,Golgi apparatus" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 29: Non-specific - Vesicular transport" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 10: Non-specific - Unknown function" "Nuclear membrane" "Golgi apparatus" "HPA047533: AB_2680078" "unprognostic (8.81e-3)" "unprognostic (1.97e-1)" "unprognostic (3.19e-2)" "prognostic favorable (1.94e-5)" "unprognostic (3.39e-2)" "prognostic unfavorable (5.99e-5)" "unprognostic (1.51e-1)" "unprognostic (1.95e-1)" "unprognostic (2.79e-1)" "unprognostic (1.42e-2)" "unprognostic (6.17e-2)" "unprognostic (6.24e-2)" "unprognostic (1.09e-2)" "unprognostic (1.04e-1)" "unprognostic (1.80e-1)" "prognostic favorable (2.95e-4)" "unprognostic (7.89e-2)" 142.9 138.1 66.2 83.4 69.4 172.2 136.2 69.0 80.4 147.1 76.6 110.8 82.9 111.0 202.5 81.6 103.6 97.5 98.4 63.7 72.6 137.2 152.3 107.9 112.6 74.1 67.2 168.6 139.4 114.6 84.5 115.1 73.9 82.0 124.9 37.0 95.9 87.5 154.3 70.5 86.4 96.3 72.4 86.2 95.3 61.5 69.4 93.2 177.5 147.4 98.2 137.3 94.0 75.3 201.7 320.7 286.7 425.4 368.5 462.8 225.4 310.1 356.5 241.9 291.2 347.1 443.0 99.0 198.8 370.3 277.2 408.3 409.1 243.4 255.5 267.1 239.4 279.4 358.8 324.9 311.7 213.4 281.2 315.8 305.0 169.1 285.1 366.0 337.9 116.7 295.8 244.3 315.1 363.1 89.2 345.8 282.1 266.2 135.4 101.6 368.4 302.9 472.6 424.4 131.2 300.8 257.3 239.5 598.5 407.0 248.5 416.6 254.3 240.0 181.0 209.8 361.9 224.4 509.6 150.0 226.4 331.7 180.6 83.5 161.1 89.7 95.1 173.7 95.0 101.0 114.8 104.7 165.8 90.0 95.1 98.0 111.6 134.3 184.8 160.9 168.8 200.8 66.2 69.4 69.0 80.4 63.7 72.6 74.1 67.2 73.9 72.4 69.4 75.3 261.1 89.8 99.1 25.8 131.8 107.1 179.4 356.6 90.5 30.0 163.7 202.6 68.2 228.8 188.0 128.8 22.9 309.1 171.9 111.1 238.7 258.8 46.3 118.5 268.0 217.2 157.4 101.7 21.2 247.3 655.3 206.0 120.8 184.1 218.4 191.0 197.7 165.5 363.3 20.2 22.8 218.7 168.9 386.7 337.2 100.6 299.5 337.3 158.3 24.4 396.7 110.5 204.9 26.7 38.3 183.4 136.3 166.3 197.9 185.7 142.7 350.9 99.3 38.2 170.9 173.5 225.5 233.5 169.6 135.2 119.9 305.8 153.4 237.6 210.7 242.2 SEC11C "SEC11L3, SPC21, SPCS4C" ENSG00000166562 "SEC11 homolog C, signal peptidase complex subunit" Q9BY50 18 59139866-59158832 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Ionocytes: 685.6;Muller glia cells: 544.7;Plasma cells: 1164.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 523.5;Karpas-707: 546.2;RPMI-8226: 1150.0;U-266/70: 587.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026816, HPA047533" Approved Approved "Nuclear membrane,Golgi apparatus" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 22: Non-specific - Unknown function" "Cluster 25: RPMI-8226 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" "Nuclear membrane" "Golgi apparatus" "HPA026816: AB_10602089, HPA047533: AB_2680078" "unprognostic (1.47e-2)" "unprognostic (2.20e-2)" "unprognostic (1.26e-1)" "unprognostic (2.44e-2)" "unprognostic (3.13e-3)" "unprognostic (4.48e-3)" "unprognostic (2.95e-1)" "unprognostic (2.32e-2)" "unprognostic (1.15e-1)" "unprognostic (4.33e-2)" "unprognostic (1.80e-2)" "unprognostic (1.72e-1)" "unprognostic (6.25e-2)" "unprognostic (3.83e-2)" "unprognostic (4.63e-2)" "unprognostic (2.58e-1)" "unprognostic (1.15e-1)" 24.6 76.7 110.0 86.5 117.5 63.1 81.8 122.9 140.5 57.8 94.4 92.3 126.7 40.1 284.6 42.5 41.4 47.3 30.0 112.9 146.4 70.2 219.0 62.7 104.2 137.3 130.2 29.9 374.0 153.9 155.2 28.4 136.8 225.7 78.2 108.1 397.3 62.3 15.7 29.7 97.8 30.1 123.7 81.4 138.5 28.1 113.5 53.0 163.7 20.0 117.8 59.4 21.2 135.8 82.4 100.0 52.9 74.1 31.9 6.8 64.7 72.4 62.9 89.9 55.2 78.3 42.5 176.8 109.9 46.6 67.6 82.8 84.7 59.0 58.4 523.5 113.8 58.5 69.3 242.3 99.3 199.4 87.6 20.4 140.7 56.2 161.1 20.2 33.7 78.4 67.4 546.2 34.6 100.0 79.0 79.2 48.1 140.4 60.5 72.8 50.0 1150.0 67.5 76.1 223.2 90.5 43.1 162.5 252.8 29.9 76.0 148.5 24.7 98.5 45.4 36.5 86.9 587.3 434.4 176.0 99.4 131.8 124.5 76.4 70.7 57.9 146.1 97.6 187.6 197.8 150.4 142.5 78.8 127.9 77.7 105.4 12.2 108.3 108.8 299.6 223.7 222.1 110.0 117.5 122.9 140.5 112.9 146.4 137.3 130.2 136.8 123.7 113.5 135.8 64.8 28.9 120.7 19.2 295.9 32.6 49.3 92.4 12.5 63.6 120.0 128.3 59.3 144.4 102.5 60.7 50.1 70.8 148.7 76.3 88.0 164.4 45.4 58.7 34.2 60.3 339.3 43.8 12.2 263.1 109.1 29.2 60.6 147.1 47.5 21.5 56.4 224.7 112.9 50.5 13.3 223.1 685.6 37.1 56.9 18.8 12.5 63.9 256.1 10.3 46.4 544.7 96.8 17.1 31.2 148.9 78.4 23.0 1164.8 380.9 99.3 118.8 81.3 89.3 6.6 23.1 70.6 110.2 81.5 35.5 45.5 149.7 92.3 40.1 88.3 79.2 SENP1 ENSG00000079387 "SUMO specific peptidase 1" Q9P0U3 12 48042897-48106079 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "salivary gland: 32.5;testis: 61.8" "Cell type enhanced" "Detected in many" "Spermatocytes: 86.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA011765, HPA046491" Supported "Nucleoplasm,Focal adhesion sites" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 23: Testis - Cell cycle regulation" "Cluster 32: U-937 - Innate immune response" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Nucleoplasm "Focal adhesion sites" "HPA011765: AB_1079907, HPA046491: AB_2679672" "unprognostic (2.66e-2)" "unprognostic (6.51e-2)" "unprognostic (3.14e-1)" "unprognostic (5.69e-2)" "unprognostic (2.83e-1)" "unprognostic (1.09e-1)" "prognostic unfavorable (7.72e-5)" "unprognostic (6.48e-2)" "unprognostic (2.44e-3)" "unprognostic (8.20e-3)" "unprognostic (2.57e-1)" "unprognostic (2.23e-1)" "prognostic unfavorable (8.37e-4)" "unprognostic (7.61e-2)" "unprognostic (3.02e-1)" "unprognostic (1.01e-1)" "unprognostic (1.28e-1)" 5.0 3.6 3.1 9.1 3.9 14.4 5.6 8.3 3.7 6.2 1.9 4.9 4.8 7.5 5.1 7.5 4.7 5.5 3.8 2.7 5.0 3.8 3.8 4.6 12.0 3.0 3.6 5.5 4.4 6.3 3.3 6.5 3.7 4.8 6.8 6.5 32.5 4.7 3.7 6.8 4.7 7.0 2.2 6.3 4.8 61.8 3.4 12.2 5.8 4.3 12.9 6.1 3.9 5.0 13.8 17.7 22.4 16.3 6.4 9.8 15.7 14.9 17.1 25.8 20.7 22.2 22.3 38.0 12.8 13.9 9.9 13.0 28.0 13.0 25.7 34.6 11.4 33.9 17.9 10.9 10.1 32.2 22.4 7.4 10.4 22.7 20.1 11.4 13.7 25.2 30.2 15.9 13.4 12.0 40.1 11.2 20.0 9.5 12.8 36.6 23.6 19.1 7.2 17.3 22.8 15.4 21.9 13.2 8.8 12.7 20.6 14.4 12.2 21.1 18.4 12.5 16.4 18.4 32.5 36.7 13.3 71.4 10.0 0.8 0.8 2.9 1.6 1.1 2.1 1.0 1.6 1.6 1.4 1.8 1.4 1.5 1.6 1.6 0.8 1.5 1.9 1.0 3.1 3.9 8.3 3.7 2.7 5.0 3.0 3.6 3.7 2.2 3.4 5.0 11.2 9.6 8.9 18.9 14.3 3.7 4.7 4.7 6.8 7.9 6.7 4.7 3.2 4.3 7.6 3.7 4.2 4.0 9.1 3.6 3.9 3.9 16.7 5.6 11.6 9.1 3.5 11.1 14.0 6.5 3.4 7.3 7.7 5.0 6.3 9.8 6.8 6.6 4.5 15.2 15.9 4.2 8.2 9.5 4.2 6.0 6.2 7.7 1.8 15.0 7.2 5.2 5.2 17.6 17.8 5.8 1.9 6.8 13.5 4.4 2.8 3.7 4.6 8.7 0.0 9.8 8.3 86.5 31.0 8.5 6.1 2.7 12.2 7.4 4.2 3.8 SENP2 "AXAM2, DKFZp762A2316, KIAA1331, SMT3IP2" ENSG00000163904 "SUMO specific peptidase 2" Q9HC62 3 185582496-185633551 "Enzymes, Plasma proteins, Predicted intracellular proteins, Transporters" "mRNA transport, Protein transport, Translocation, Transport, Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 249.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029247, HPA029248" Approved Supported Cytosol NA NA "Cluster 34: Basophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 5: NTERA-2 - Transcription" "Cluster 29: Early spermatids - Spermatogenesis" Cytosol "HPA029247: AB_10599305, HPA029248: AB_10601855" "unprognostic (4.57e-2)" "unprognostic (1.84e-2)" "unprognostic (6.80e-2)" "prognostic unfavorable (7.98e-5)" "unprognostic (7.85e-2)" "unprognostic (2.90e-2)" "unprognostic (4.41e-3)" "unprognostic (1.45e-1)" "unprognostic (1.59e-1)" "unprognostic (1.46e-1)" "unprognostic (1.85e-1)" "unprognostic (8.41e-3)" "unprognostic (5.12e-2)" "unprognostic (6.92e-2)" "unprognostic (1.60e-1)" "unprognostic (1.92e-1)" "unprognostic (1.56e-1)" 7.4 7.3 13.4 4.4 15.8 10.7 7.5 13.3 16.2 6.0 12.0 7.8 6.0 6.1 9.7 6.5 7.2 4.5 8.3 13.9 13.1 7.3 9.5 6.4 6.2 12.9 13.6 10.0 7.4 9.6 10.5 9.0 12.4 6.6 6.1 12.8 7.6 6.3 18.9 9.2 6.6 4.8 12.2 6.7 8.0 15.1 14.2 8.1 7.2 13.0 6.0 7.1 6.3 14.4 24.4 4.6 11.6 13.4 20.6 13.8 15.1 10.9 12.6 13.8 14.6 18.3 7.5 13.2 20.3 10.2 23.6 12.6 24.3 9.0 20.3 9.7 11.6 8.9 9.8 11.0 10.9 13.2 5.6 8.6 13.3 7.8 9.5 10.2 9.6 12.5 10.8 18.1 12.0 12.0 11.4 14.7 42.4 12.3 8.1 13.1 15.8 22.1 7.7 7.9 11.9 13.4 9.3 20.4 18.3 23.0 27.8 17.5 6.1 9.0 9.8 16.4 17.7 20.9 26.8 23.8 14.9 13.9 12.5 5.1 1.3 2.6 1.6 1.3 1.6 1.3 1.3 1.3 1.0 1.9 1.5 1.5 3.4 2.3 1.6 2.0 1.3 0.9 13.4 15.8 13.3 16.2 13.9 13.1 12.9 13.6 12.4 12.2 14.2 14.4 12.3 28.9 27.4 17.9 21.2 10.8 23.7 12.6 6.2 22.8 21.6 15.4 24.2 11.5 26.2 9.2 31.3 25.0 22.6 15.7 5.9 12.9 249.6 26.3 12.0 12.8 5.4 11.1 42.9 15.2 19.9 16.1 15.3 25.2 10.8 21.3 17.2 20.5 13.2 11.8 43.0 15.1 14.2 12.5 9.1 43.0 22.7 11.1 17.8 26.2 13.6 17.8 21.6 41.2 41.3 17.9 6.6 17.7 25.7 17.0 24.2 18.2 28.8 38.1 19.7 23.2 16.3 84.2 31.8 13.4 12.5 39.7 18.2 33.7 15.8 22.5 SENP3 "DKFZP586K0919, DKFZp762A152, SMT3IP1, SSP3, Ulp1" ENSG00000161956 "SUMO specific peptidase 3" Q9H4L4 17 7561919-7571969 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 22.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" HPA060290 Supported Supported Nucleoplasm,Nucleoli Yes No "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 9: Photoreceptor cells - Phototransduction" "Nucleoplasm, Nucleoli" "HPA060290: AB_2684244" "unprognostic (5.68e-2)" "unprognostic (2.39e-1)" "unprognostic (1.65e-1)" "unprognostic (1.01e-1)" "unprognostic (3.34e-1)" "unprognostic (3.48e-1)" "unprognostic (1.30e-3)" "unprognostic (2.82e-1)" "unprognostic (7.37e-2)" "unprognostic (3.72e-2)" "prognostic favorable (6.22e-5)" "unprognostic (2.71e-2)" "unprognostic (1.96e-1)" "unprognostic (1.42e-1)" "unprognostic (1.37e-1)" "unprognostic (8.21e-2)" "unprognostic (2.56e-2)" 24.2 24.0 43.7 21.0 42.6 25.4 23.7 38.5 47.9 23.7 38.5 32.4 21.2 26.7 27.4 25.4 25.9 19.3 25.2 42.6 39.8 34.1 20.5 28.6 26.5 40.4 42.2 26.8 26.4 38.1 26.4 22.5 41.1 23.0 25.4 24.7 24.8 26.0 33.5 28.6 25.2 28.9 39.5 28.3 27.0 29.0 44.0 33.8 23.9 30.9 31.2 29.7 21.8 42.0 76.4 90.8 52.7 82.5 58.6 42.8 54.8 54.8 56.0 93.4 87.2 54.9 32.5 90.3 52.6 72.7 62.3 72.0 114.4 85.8 78.0 63.7 105.0 46.7 74.8 56.9 79.1 44.0 57.9 55.1 86.5 107.1 103.5 53.3 76.0 102.1 61.5 24.7 73.0 51.4 107.9 33.6 64.2 70.9 54.5 97.1 48.8 52.4 62.9 44.0 52.5 67.6 55.3 52.7 60.0 66.6 44.1 28.5 40.5 53.0 45.9 51.3 119.0 36.3 40.4 57.3 53.9 45.7 80.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 43.7 42.6 38.5 47.9 42.6 39.8 40.4 42.2 41.1 39.5 44.0 42.0 4.5 3.2 5.4 0.0 4.9 8.5 6.4 1.6 10.2 6.1 6.7 11.0 7.1 7.2 3.6 1.8 22.9 3.0 4.8 2.6 0.0 2.3 1.4 4.0 4.2 4.7 6.6 1.3 0.0 2.4 2.3 3.8 3.6 4.7 1.3 5.2 8.2 2.7 1.5 6.7 0.0 3.0 2.0 6.0 6.4 0.7 4.1 4.9 3.6 0.0 4.7 5.5 4.1 0.0 0.0 2.1 0.8 2.2 6.4 6.1 4.0 1.1 2.1 7.3 0.0 5.2 4.4 3.7 4.0 7.4 11.6 4.1 4.9 3.0 3.7 6.4 SENP5 MGC27076 ENSG00000119231 "SUMO specific peptidase 5" Q96HI0 3 196867856-196934714 "Enzymes, Predicted intracellular proteins" "Cell cycle, Cell division, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 16: U-266 - Nucleosome" "Cluster 44: Endometrium - Transcription" "unprognostic (4.07e-2)" "unprognostic (4.91e-3)" "unprognostic (7.63e-2)" "prognostic unfavorable (4.04e-4)" "unprognostic (4.13e-1)" "unprognostic (1.08e-1)" "prognostic unfavorable (4.15e-4)" "unprognostic (2.95e-1)" "unprognostic (2.20e-1)" "unprognostic (2.88e-1)" "unprognostic (2.89e-1)" "unprognostic (9.57e-3)" "prognostic unfavorable (2.14e-5)" "unprognostic (2.02e-1)" "unprognostic (1.62e-1)" "unprognostic (1.62e-2)" "unprognostic (6.71e-2)" 8.1 7.0 12.3 8.3 12.2 15.8 8.1 14.4 14.0 10.6 9.9 10.3 5.8 8.4 7.9 8.5 9.1 7.3 9.3 13.0 14.6 7.8 10.1 9.9 9.0 13.3 13.1 10.4 8.1 8.9 10.2 9.1 14.3 9.3 7.0 17.5 7.7 7.4 11.9 9.4 8.3 7.8 11.3 10.5 8.2 20.8 12.7 10.6 8.3 12.2 11.5 9.0 9.8 15.9 26.0 11.1 18.1 16.4 15.0 17.8 14.7 16.2 17.1 17.1 27.2 20.2 10.0 24.3 44.1 17.6 29.1 17.8 18.9 8.6 27.5 13.1 13.3 32.8 17.1 14.3 17.4 27.1 14.8 15.5 22.7 17.4 18.4 12.4 16.9 21.0 22.2 36.1 20.2 22.1 26.1 16.0 14.2 14.0 23.4 16.5 14.7 16.6 8.4 14.5 11.3 15.0 18.9 20.1 19.8 18.0 33.8 20.5 19.3 16.5 17.2 23.0 33.5 38.6 73.6 51.4 22.4 21.7 19.3 16.3 6.5 6.3 7.1 7.1 6.4 7.4 6.8 7.0 4.3 7.0 6.3 6.7 12.5 6.5 8.1 6.9 5.9 3.6 12.3 12.2 14.4 14.0 13.0 14.6 13.3 13.1 14.3 11.3 12.7 15.9 25.7 22.4 12.6 43.4 27.7 60.8 28.4 8.6 16.5 28.6 22.7 13.0 14.6 12.8 13.2 9.2 16.7 18.3 33.4 19.9 11.7 16.0 42.9 22.1 26.9 21.6 21.6 19.3 71.2 14.2 15.7 21.1 18.8 27.5 26.6 25.9 22.5 17.6 13.4 28.6 69.1 16.6 8.2 20.4 41.4 48.0 16.1 17.4 14.2 48.7 18.7 13.8 27.8 50.8 57.3 27.4 19.4 16.6 24.4 21.4 13.3 20.5 11.2 30.5 26.3 25.8 23.9 67.5 56.8 14.3 62.1 22.8 25.7 13.7 13.8 36.1 SENP6 "KIAA0797, SUSP1" ENSG00000112701 "SUMO specific peptidase 6" Q9GZR1 6 75601509-75718281 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024376 Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 34: Non-specific - Transcription" "Cluster 1: K-562 - Erythropoiesis" "Cluster 59: Non-specific - Transcription" Nucleoplasm Cytosol "HPA024376: AB_1856678" "unprognostic (9.86e-2)" "unprognostic (1.20e-2)" "unprognostic (4.84e-2)" "unprognostic (1.87e-2)" "unprognostic (6.38e-3)" "unprognostic (7.33e-2)" "unprognostic (1.13e-2)" "unprognostic (2.97e-1)" "unprognostic (3.93e-2)" "unprognostic (5.32e-3)" "unprognostic (7.81e-2)" "unprognostic (9.24e-2)" "prognostic unfavorable (6.09e-4)" "unprognostic (1.78e-1)" "unprognostic (1.74e-1)" "prognostic unfavorable (2.83e-5)" "unprognostic (1.72e-1)" 25.1 22.6 12.8 24.6 16.8 37.9 31.4 47.6 15.5 28.6 7.5 26.6 20.9 33.0 22.1 25.3 26.8 26.0 22.6 9.6 14.3 28.5 28.0 26.4 28.5 11.9 11.9 40.5 27.0 39.4 22.3 33.4 12.8 29.3 26.0 31.4 21.8 28.9 25.5 25.2 20.5 31.9 12.3 28.9 24.9 33.8 12.0 32.4 41.9 30.1 30.4 29.7 21.2 22.3 23.8 24.5 54.3 39.1 41.3 54.6 40.3 41.9 46.5 34.6 43.1 33.9 22.4 40.1 38.6 48.7 40.9 29.8 51.6 28.0 53.1 59.2 44.2 60.8 28.9 31.7 57.3 53.5 42.8 42.6 45.6 32.6 71.8 41.9 58.2 32.8 74.9 43.2 43.0 29.0 21.4 28.6 33.1 31.9 20.4 39.7 28.7 59.0 36.7 35.0 47.2 48.7 35.8 31.3 36.4 43.5 28.2 50.1 49.0 30.8 33.4 15.9 43.8 48.9 52.4 31.4 15.4 49.8 33.1 7.5 8.0 20.8 7.3 8.4 10.5 9.1 7.4 9.9 8.9 10.5 10.5 9.6 14.9 10.1 14.7 11.0 6.9 6.3 12.8 16.8 47.6 15.5 9.6 14.3 11.9 11.9 12.8 12.3 12.0 22.3 76.7 67.3 128.3 158.0 74.0 46.5 65.0 27.6 78.6 58.8 53.0 59.6 76.7 31.5 70.9 29.5 91.8 33.0 73.8 43.2 17.6 33.7 40.4 62.9 78.1 57.9 27.6 50.5 152.6 33.7 29.4 69.3 51.0 62.9 65.1 74.2 42.1 32.0 29.5 60.6 177.3 35.6 24.4 43.2 41.5 35.6 70.8 57.7 35.6 149.9 68.4 56.6 50.4 218.1 228.9 32.1 29.9 63.2 62.8 63.4 32.6 26.8 47.2 65.7 26.3 98.9 73.7 107.7 61.7 61.4 48.4 41.2 67.2 66.0 46.3 66.8 SENP7 ENSG00000138468 "SUMO specific peptidase 7" Q9BQF6 3 101324205-101513241 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Inhibitory neurons: 109.6;Oligodendrocyte precursor cells: 157.3;Oligodendrocytes: 134.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 44.1" "Lineage enriched" "Detected in all" 4 "granulocytes: 44.1" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027259, HPA071998" Approved Supported "Nucleoplasm,Nuclear bodies,Centrosome,Cytosol" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 34: Non-specific - Transcription" "Cluster 12: NES - Nervous system development" "Cluster 68: Oligodendrocytes - Mixed function" Nucleoplasm "Nuclear bodies, Centrosome, Cytosol" "HPA027259: AB_1856679, HPA071998: " "unprognostic (1.50e-1)" "unprognostic (6.12e-2)" "unprognostic (2.78e-2)" "unprognostic (7.31e-2)" "unprognostic (2.44e-2)" "prognostic favorable (4.23e-4)" "unprognostic (1.38e-3)" "unprognostic (9.25e-3)" "unprognostic (8.80e-2)" "unprognostic (2.24e-1)" "unprognostic (7.77e-3)" "unprognostic (1.94e-1)" "unprognostic (9.85e-2)" "unprognostic (8.08e-3)" "unprognostic (3.27e-1)" "unprognostic (9.03e-2)" "unprognostic (2.23e-2)" 15.1 9.7 9.7 13.7 12.7 24.7 16.9 21.8 11.8 15.8 9.7 12.5 7.3 26.8 14.7 7.8 16.1 14.2 9.5 9.3 12.3 11.4 8.7 12.8 23.1 13.9 11.7 26.3 12.8 16.9 10.2 19.4 14.0 12.7 10.8 26.0 8.9 11.5 11.2 20.8 12.4 14.7 10.1 16.9 14.1 9.1 11.5 20.5 17.5 11.2 17.7 11.8 11.4 20.3 9.2 6.1 29.4 16.4 5.6 8.2 5.3 5.2 3.8 8.5 10.4 4.0 8.3 7.0 7.9 5.1 7.8 9.1 9.4 4.8 17.0 13.0 2.7 12.7 5.1 5.5 4.5 7.4 12.2 6.4 8.5 4.3 9.6 7.6 12.2 13.4 10.5 17.6 8.1 6.1 13.7 8.6 6.0 4.8 6.3 15.2 8.0 6.4 10.1 5.2 11.3 8.8 4.8 4.8 6.5 15.0 8.0 9.8 10.2 11.8 7.1 3.9 5.2 12.2 7.8 16.4 4.1 9.7 9.8 44.1 5.9 5.9 5.8 5.4 7.3 6.4 7.8 5.8 4.8 9.0 10.3 7.1 17.3 9.3 6.3 4.1 6.9 6.1 9.7 12.7 21.8 11.8 9.3 12.3 13.9 11.7 14.0 10.1 11.5 20.3 44.5 16.0 24.9 78.4 33.0 9.1 8.4 7.4 21.1 48.3 14.4 12.2 21.6 2.8 18.4 16.5 20.9 5.8 30.8 5.4 5.9 8.1 4.1 33.1 48.5 28.4 13.1 18.7 62.4 5.2 2.7 23.4 21.4 34.1 37.2 28.6 32.9 10.3 8.2 52.2 109.6 6.5 12.2 20.5 9.5 4.0 18.3 19.1 10.6 80.6 13.6 16.7 35.0 157.3 134.4 6.9 4.1 19.5 23.5 4.8 7.0 8.5 27.5 33.8 46.0 29.7 23.3 22.8 19.9 13.4 9.9 2.5 41.0 21.1 5.9 6.1 SENP8 "DEN1, HsT17512, NEDP1, PRSC2" ENSG00000166192 "SUMO peptidase family member, NEDD8 specific" Q96LD8 15 72114258-72143692 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 15.6" "Group enriched" "Detected in many" 11 "Early spermatids: 86.5;Late spermatids: 222.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036273 Approved Approved Nucleoplasm,Vesicles NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Vesicles" "HPA036273: AB_10669985" "unprognostic (1.83e-2)" "unprognostic (1.78e-1)" "unprognostic (9.85e-4)" "unprognostic (5.43e-2)" "unprognostic (1.49e-1)" "unprognostic (6.09e-3)" "unprognostic (3.06e-2)" "unprognostic (4.35e-2)" "unprognostic (1.06e-1)" "unprognostic (2.04e-1)" "unprognostic (3.11e-2)" "unprognostic (1.19e-1)" "unprognostic (8.46e-12)" "unprognostic (1.24e-1)" "unprognostic (1.12e-1)" "unprognostic (1.85e-2)" "unprognostic (1.54e-2)" 1.1 1.7 2.7 1.1 2.4 2.8 2.0 1.1 3.1 1.7 0.0 1.9 1.8 1.7 3.3 2.3 2.5 1.9 4.0 2.2 2.1 4.4 2.5 1.5 1.5 1.4 1.7 2.4 1.5 2.4 2.1 1.7 1.9 2.1 1.9 4.6 1.6 1.7 6.3 1.6 1.5 1.6 0.4 1.5 2.0 15.6 1.7 1.5 5.0 5.7 1.2 1.7 1.0 2.6 1.5 2.7 4.7 3.8 5.6 6.9 2.7 4.1 2.5 2.2 2.0 2.1 3.4 1.5 5.7 2.4 4.0 3.4 7.4 5.9 3.3 1.6 4.0 2.5 3.7 1.9 3.9 2.8 1.3 3.3 5.8 1.4 6.2 2.9 2.1 4.4 3.7 2.7 5.4 3.8 2.9 3.7 4.0 3.4 2.5 1.9 4.2 3.3 6.0 2.6 5.8 2.0 4.4 3.3 4.2 5.6 5.1 2.1 2.2 4.5 1.7 7.8 2.0 2.2 2.9 1.8 2.1 4.0 3.3 1.1 0.9 0.7 0.8 2.2 1.1 1.9 1.3 1.2 2.9 0.6 1.5 1.8 0.3 3.5 3.2 0.8 1.1 1.0 2.7 2.4 1.1 3.1 2.2 2.1 1.4 1.7 1.9 0.4 1.7 2.6 1.2 6.4 5.3 3.9 0.4 0.3 1.4 2.5 1.2 4.5 2.4 2.4 5.4 1.5 4.5 1.8 4.2 6.7 0.3 1.5 13.7 3.3 86.5 2.5 2.7 1.8 1.2 3.2 4.6 1.7 3.4 2.6 4.1 2.6 0.0 3.4 1.8 1.5 2.1 1.7 6.1 1.5 2.0 2.6 0.6 222.9 1.8 1.7 0.0 2.8 3.8 10.6 0.0 6.0 4.0 1.4 3.2 1.2 0.2 1.7 2.3 8.1 6.0 4.0 0.0 2.3 1.3 10.7 12.6 1.4 0.4 7.8 1.0 3.0 2.2 1.0 SPG7 "CAR, CMAR, SPG5C" ENSG00000197912 "SPG7 matrix AAA peptidase subunit, paraplegin" Q9UQ90 16 89490719-89557766 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration, Osteogenesis imperfecta" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 11: Basophils - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 52: Non-specific - Transcription" "unprognostic (1.42e-1)" "unprognostic (1.72e-1)" "unprognostic (4.12e-2)" "prognostic favorable (2.22e-4)" "unprognostic (4.10e-1)" "unprognostic (1.11e-2)" "unprognostic (1.14e-1)" "unprognostic (1.50e-1)" "unprognostic (1.54e-1)" "unprognostic (2.33e-1)" "prognostic favorable (4.91e-4)" "unprognostic (3.56e-2)" "unprognostic (7.01e-2)" "unprognostic (1.44e-2)" "unprognostic (2.58e-1)" "unprognostic (1.71e-1)" "prognostic favorable (4.25e-4)" 29.8 44.8 19.3 7.0 18.8 8.2 27.9 21.3 28.6 31.5 18.5 33.3 9.9 31.8 4.0 28.2 26.4 6.8 52.3 19.4 18.3 32.4 47.0 24.9 8.9 19.7 18.6 39.0 31.9 13.8 38.7 5.9 20.3 31.2 8.1 9.9 29.0 9.7 56.7 31.3 35.5 9.0 16.9 34.1 31.1 31.9 18.7 10.5 53.1 31.0 8.0 30.1 26.9 20.0 11.5 28.3 17.3 26.6 33.2 24.2 10.9 27.3 24.6 21.0 10.4 23.0 22.3 16.5 32.5 20.1 16.2 30.5 21.5 24.4 14.7 11.7 25.3 11.4 12.0 43.4 16.2 5.5 10.3 15.2 20.1 12.8 14.1 27.9 25.6 22.0 23.1 5.5 21.7 21.0 14.4 22.5 21.9 23.8 21.4 31.8 26.2 10.8 15.9 17.3 16.4 10.5 44.9 8.3 9.5 15.2 22.6 17.0 33.7 13.9 17.2 12.0 12.2 13.7 19.8 12.8 17.7 19.8 17.7 4.5 2.5 3.9 2.7 2.4 2.6 1.6 1.7 1.3 2.8 3.4 3.1 2.0 2.9 3.7 1.7 2.3 1.8 1.0 19.3 18.8 21.3 28.6 19.4 18.3 19.7 18.6 20.3 16.9 18.7 20.0 53.9 48.1 49.4 39.2 45.6 15.9 27.9 30.1 44.9 57.8 31.2 37.2 45.8 22.8 41.5 35.0 95.9 39.9 47.6 42.3 19.6 40.0 66.0 50.5 41.7 49.9 37.2 27.3 58.5 25.8 28.8 35.9 67.2 54.1 21.5 95.3 51.0 38.1 32.2 40.4 53.1 43.8 30.5 34.8 21.8 22.1 42.9 35.2 21.4 35.6 42.6 30.5 51.5 87.0 46.2 39.5 39.5 33.4 43.5 29.5 68.2 23.8 37.7 73.7 6.6 36.9 36.2 57.5 36.5 36.7 18.0 25.9 45.5 68.3 51.0 28.7 SPPL2A "IMP3, PSL2" ENSG00000138600 "Signal peptide peptidase like 2A" Q8TCT8 15 50702266-50765709 "Enzymes, Plasma proteins, Predicted membrane proteins, Transporters" "Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036062, HPA067304" Enhanced Supported Vesicles NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" Vesicles "HPA036062: AB_10611670, HPA067304: AB_2685820" "unprognostic (1.66e-1)" "unprognostic (1.03e-1)" "unprognostic (2.70e-1)" "unprognostic (5.82e-3)" "unprognostic (3.71e-1)" "unprognostic (1.70e-1)" "unprognostic (2.15e-1)" "unprognostic (1.88e-1)" "unprognostic (2.22e-2)" "unprognostic (6.36e-2)" "unprognostic (2.04e-2)" "unprognostic (4.00e-2)" "unprognostic (3.11e-2)" "unprognostic (2.26e-2)" "unprognostic (1.44e-2)" "unprognostic (6.96e-2)" "unprognostic (3.66e-1)" 41.1 34.7 8.3 57.6 10.9 54.5 32.0 11.1 8.5 36.6 48.6 93.4 79.6 27.9 21.5 26.5 26.8 39.4 37.1 6.8 12.3 57.9 107.0 43.4 40.2 15.3 12.8 13.6 63.7 158.5 13.0 54.1 12.5 29.5 82.8 12.5 44.5 32.6 109.3 25.2 67.6 41.0 11.2 37.3 41.7 18.5 12.1 39.5 35.2 81.8 41.7 51.7 20.9 14.5 57.3 96.9 37.0 49.2 142.3 84.3 58.2 89.1 149.1 80.5 114.1 113.1 64.3 35.1 65.0 176.3 120.7 83.5 45.2 54.3 89.5 72.2 27.5 67.0 61.5 58.9 117.4 42.0 104.5 73.9 98.3 66.8 106.7 59.4 80.2 37.7 51.3 134.2 107.6 131.5 20.1 16.2 15.8 90.8 22.0 24.2 57.3 77.6 109.7 130.4 29.7 33.4 54.0 102.7 63.4 74.0 73.2 81.6 98.9 128.7 51.7 83.7 106.7 54.0 100.2 38.8 58.1 69.4 90.3 48.7 52.3 48.9 27.9 48.6 17.4 18.3 22.3 25.5 37.4 19.2 12.4 20.5 37.7 23.5 56.6 33.1 30.4 50.2 8.3 10.9 11.1 8.5 6.8 12.3 15.3 12.8 12.5 11.2 12.1 14.5 66.2 48.1 35.9 20.5 51.9 43.1 79.1 76.3 37.5 14.8 36.4 21.3 77.5 52.9 44.3 68.0 20.9 136.5 72.7 215.5 23.5 87.1 18.8 107.2 56.6 59.6 38.4 30.3 32.0 167.1 88.3 74.3 52.0 57.3 45.7 20.5 46.8 124.1 85.9 8.4 31.4 86.5 36.7 68.7 55.7 7.0 44.7 83.0 32.0 23.4 134.5 27.5 64.9 25.6 26.2 131.9 127.3 36.5 49.9 92.2 143.0 46.8 41.8 17.2 26.3 88.0 51.6 31.7 15.3 39.3 38.8 204.5 60.6 30.8 76.0 94.1 SPPL2B "IMP4, KIAA1532, PSL1" ENSG00000005206 "Signal peptide peptidase like 2B" Q8TCT7 19 2328615-2355095 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Gastric mucus-secreting cells: 109.1;Late spermatids: 107.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005592, HPA039292" Approved Approved "Nucleoplasm,Plasma membrane,Centrosome" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 20: HeLa - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Plasma membrane" Centrosome "CAB005592: AB_325074, HPA039292: AB_2676429" "unprognostic (4.16e-2)" "unprognostic (2.97e-2)" "unprognostic (2.48e-2)" "prognostic favorable (5.00e-5)" "unprognostic (2.34e-1)" "unprognostic (1.54e-3)" "unprognostic (1.74e-1)" "unprognostic (7.93e-3)" "unprognostic (3.00e-1)" "unprognostic (1.72e-1)" "prognostic favorable (1.33e-4)" "unprognostic (3.29e-3)" "prognostic unfavorable (6.45e-4)" "unprognostic (2.26e-2)" "unprognostic (2.45e-1)" "unprognostic (3.02e-1)" "unprognostic (3.40e-2)" 23.1 23.2 13.7 16.7 13.6 29.1 27.4 15.5 18.6 28.4 17.4 43.4 41.6 26.4 4.4 22.5 34.0 10.7 21.6 11.8 12.1 35.9 33.0 22.2 20.7 19.2 15.6 27.2 50.7 11.0 63.8 10.4 15.5 32.5 9.2 7.1 27.2 9.8 25.3 28.9 52.6 5.9 13.2 39.1 33.9 63.5 15.1 12.0 40.5 3.1 9.9 21.9 20.9 16.4 16.6 25.9 10.9 19.5 8.8 8.9 27.8 21.1 6.1 7.6 8.1 18.2 18.4 15.7 19.4 9.9 7.1 21.7 3.6 7.3 2.3 18.4 16.0 10.4 44.7 24.9 16.5 18.6 13.1 13.1 8.2 7.2 5.2 11.9 10.7 32.2 17.3 39.0 4.7 18.4 20.2 23.6 20.4 14.7 10.5 33.4 5.8 43.9 8.3 41.0 19.4 18.3 21.2 12.8 16.7 7.1 21.3 30.8 24.3 13.8 9.7 35.3 16.9 51.0 20.1 16.7 17.3 21.4 24.5 11.5 7.7 7.4 6.2 7.7 4.4 8.2 5.6 6.0 9.4 12.5 6.9 7.7 3.3 6.4 5.4 17.0 6.0 6.4 13.7 13.6 15.5 18.6 11.8 12.1 19.2 15.6 15.5 13.2 15.1 16.4 23.6 3.2 17.2 57.1 30.8 0.0 6.5 0.0 8.0 26.1 21.6 21.5 6.0 20.0 5.0 25.8 47.9 50.6 18.8 79.5 1.9 16.6 51.4 39.3 22.2 14.4 40.7 14.5 25.3 11.5 20.8 14.2 109.1 25.5 7.0 39.9 13.2 15.1 11.8 32.0 30.3 63.2 0.0 9.4 0.0 107.7 14.9 10.8 0.0 9.4 8.0 13.2 19.6 39.7 35.2 10.4 49.9 15.8 11.5 7.3 57.8 7.9 10.9 39.4 0.0 15.0 11.7 57.0 13.5 10.8 0.0 42.8 11.0 36.4 49.8 6.0 SPPL2C IMP5 ENSG00000185294 "Signal peptide peptidase like 2C" Q8IUH8 17 45844881-45847067 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 73 "testis: 36.8" "Group enriched" "Detected in some" 146 "Early spermatids: 202.7;Late spermatids: 615.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA077339 Supported NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 34: Spermatids - Unknown function" "HPA077339: " "unprognostic (6.70e-4)" "unprognostic (1.34e-1)" 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 36.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 202.7 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 615.6 2.8 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.5 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SPPL3 "DKFZP586C1324, IMP2, MGC126674, MGC126676, MGC90402, PSL4" ENSG00000157837 "Signal peptide peptidase like 3" Q8TCT6 12 120762510-120904358 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 192.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004194, HPA059958" Uncertain Supported "Vesicles,Plasma membrane" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 27: Brain & Skin - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 40: Granulosa cells - Unknown function" "Vesicles, Plasma membrane" "HPA004194: AB_2667171, HPA059958: AB_2684179" "unprognostic (3.29e-1)" "unprognostic (2.29e-2)" "unprognostic (3.39e-2)" "unprognostic (1.63e-1)" "unprognostic (2.06e-1)" "unprognostic (7.96e-3)" "prognostic unfavorable (1.29e-5)" "unprognostic (3.17e-2)" "unprognostic (1.10e-1)" "unprognostic (1.28e-1)" "unprognostic (2.48e-1)" "unprognostic (2.44e-1)" "unprognostic (2.66e-1)" "unprognostic (9.34e-2)" "unprognostic (9.92e-2)" "unprognostic (7.54e-2)" "unprognostic (9.40e-2)" 20.9 14.9 25.3 11.9 28.1 20.9 24.2 29.0 27.5 30.0 13.1 26.7 18.2 26.3 15.7 44.3 28.6 18.7 18.1 25.4 30.6 22.8 19.3 20.4 15.9 25.0 26.0 31.4 21.3 49.6 13.9 28.4 26.1 20.6 27.2 15.5 20.2 27.0 15.7 56.5 18.8 29.6 24.1 24.3 15.2 39.0 26.4 32.7 31.2 19.6 27.8 28.6 34.2 31.4 30.0 29.2 43.4 27.4 56.2 37.7 30.5 22.5 66.6 47.4 37.9 30.5 29.9 27.4 0.1 39.4 42.0 35.6 44.8 48.4 48.9 21.9 27.5 23.6 16.2 23.4 59.2 27.4 29.3 38.1 75.9 40.7 38.1 56.0 47.1 41.5 26.5 13.4 41.2 26.3 36.7 22.0 29.2 27.8 20.6 21.6 36.6 19.7 36.8 83.8 29.7 31.9 42.8 19.6 34.7 46.1 58.9 18.7 35.4 21.9 29.5 13.6 17.1 30.9 60.3 26.4 32.5 22.3 36.9 4.8 1.2 1.1 1.3 1.2 1.8 1.3 1.6 1.7 2.1 1.6 1.5 1.7 2.2 1.3 1.1 2.7 1.4 0.7 25.3 28.1 29.0 27.5 25.4 30.6 25.0 26.0 26.1 24.1 26.4 31.4 35.2 19.2 20.8 79.3 25.3 55.1 32.3 29.4 43.3 37.8 35.2 24.1 21.2 20.0 19.8 40.5 27.1 42.0 21.2 47.2 1.9 19.3 8.6 20.9 26.9 33.0 27.1 14.5 97.2 24.7 29.0 33.2 25.0 29.7 4.5 68.7 37.5 33.1 38.3 37.0 112.6 33.7 22.4 38.1 39.3 8.0 28.6 34.5 26.6 79.6 26.6 23.0 16.5 141.3 192.3 22.8 34.9 35.0 22.0 33.4 34.0 18.1 18.1 22.4 13.1 32.3 27.4 55.6 41.1 76.9 84.7 64.6 22.4 35.0 35.4 37.6 ST14 "HAI, MT-SP1, PRSS14, SNC19, TMPRSS14" ENSG00000149418 "ST14 transmembrane serine protease matriptase" Q9Y5Y6 11 130159782-130210362 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Hydrolase, Protease, Serine protease" "Cancer-related genes, Disease variant, Hypotrichosis, Ichthyosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 144.8" "Cell type enhanced" "Detected in many" "Distal enterocytes: 489.4;Paneth cells: 327.2;Proximal enterocytes: 251.9;Undifferentiated cells: 216.9;Urothelial cells: 286.8" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "thalamus: 10.0" "Immune cell enriched" "Detected in many" 4 "plasmacytoid DC: 25.0" "Lineage enriched" "Detected in many" 5 "dendritic cells: 25.0" "Cell line enhanced" "Detected in many" "CACO-2: 224.2;CAPAN-2: 443.0;HaCaT: 311.4;OE19: 240.4;RPMI-8226: 301.2;SK-BR-3: 203.1;T-47d: 308.3;U-698: 218.5" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" "HPA047014, HPA056258" Enhanced Approved Nucleoplasm,Vesicles NA NA 1100000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Vesicles" "HPA047014: AB_2679902, HPA056258: " "unprognostic (1.17e-1)" "unprognostic (1.15e-1)" "unprognostic (9.62e-2)" "unprognostic (1.32e-1)" "unprognostic (2.17e-2)" "unprognostic (7.94e-2)" "unprognostic (1.20e-1)" "unprognostic (3.97e-2)" "unprognostic (5.29e-1)" "unprognostic (3.21e-1)" "unprognostic (1.03e-3)" "unprognostic (2.25e-1)" "prognostic favorable (5.03e-11)" "unprognostic (1.92e-2)" "unprognostic (2.71e-1)" "unprognostic (1.28e-2)" "unprognostic (5.60e-2)" 4.3 3.9 0.8 26.7 1.2 4.3 17.7 1.8 2.9 18.6 1.2 124.7 130.7 5.7 21.8 104.5 37.1 32.6 0.9 0.9 1.1 43.2 6.3 18.5 11.9 1.8 1.7 0.6 59.2 36.5 19.1 15.1 3.1 23.1 60.1 0.0 58.7 23.6 0.3 50.2 144.8 5.4 1.1 9.1 64.9 1.0 10.0 10.5 28.6 0.0 20.9 34.8 42.5 2.7 167.2 0.2 0.0 0.6 0.0 0.0 86.4 0.0 0.0 0.0 0.0 224.2 443.0 163.6 16.7 0.0 0.1 311.4 0.0 99.3 0.0 0.1 0.2 0.1 0.1 0.9 0.0 22.0 0.8 0.0 49.3 0.0 0.2 0.0 0.0 0.0 0.2 0.3 0.0 128.5 0.3 1.1 1.7 240.4 0.9 0.2 0.0 301.2 28.8 134.2 17.8 0.4 1.5 203.1 0.4 1.6 308.3 32.0 0.1 0.4 2.7 0.7 0.7 0.2 0.3 218.5 0.3 50.4 0.5 0.0 3.6 3.4 0.0 2.2 0.1 5.0 0.0 0.0 6.2 3.6 0.0 0.0 0.5 0.0 0.3 25.0 0.0 1.2 0.8 1.2 1.8 2.9 0.9 1.1 1.8 1.7 3.1 1.1 10.0 2.7 0.2 32.1 28.6 0.0 18.2 40.9 51.5 45.2 26.2 0.0 36.5 21.5 1.2 77.2 61.6 62.5 0.0 45.6 26.1 489.4 3.9 115.8 37.8 43.9 5.7 1.7 123.4 0.8 1.0 91.8 14.6 3.2 112.1 79.6 11.4 0.2 0.4 2.1 58.1 0.0 0.4 201.0 148.5 22.7 13.2 13.9 1.8 28.0 7.2 0.0 13.6 0.0 1.0 0.0 0.1 153.4 327.2 0.7 5.9 108.7 251.9 10.0 76.4 0.0 6.6 0.0 4.9 0.2 0.3 61.3 43.9 39.7 2.9 0.0 216.9 286.8 STAMBP AMSH ENSG00000124356 "STAM binding protein" O95630 2 73828916-73873659 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 12 "LHCN-M2: 1108.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035800, HPA035801" Uncertain Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA 18000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 80: Striated muscle - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "Plasma membrane, Cytosol" "HPA035800: AB_10670591, HPA035801: AB_2732470" "unprognostic (1.86e-2)" "unprognostic (1.14e-1)" "unprognostic (2.16e-1)" "prognostic unfavorable (4.70e-5)" "unprognostic (6.13e-2)" "unprognostic (2.08e-3)" "unprognostic (3.73e-2)" "unprognostic (1.71e-1)" "unprognostic (6.58e-2)" "unprognostic (2.96e-2)" "prognostic unfavorable (5.79e-4)" "unprognostic (1.01e-1)" "unprognostic (2.29e-1)" "unprognostic (7.72e-2)" "unprognostic (2.63e-1)" "unprognostic (1.43e-1)" "unprognostic (2.89e-1)" 15.6 11.6 21.7 14.6 30.6 13.3 20.2 29.7 23.8 19.3 19.3 21.5 20.7 20.6 15.5 25.4 18.3 16.9 22.3 20.6 24.5 21.9 19.0 15.7 19.3 31.3 28.0 17.7 12.2 24.3 9.3 17.3 30.4 22.1 23.2 14.6 21.5 15.6 37.4 16.7 20.4 21.3 27.9 14.9 18.2 15.8 27.1 23.2 22.6 42.8 21.6 16.8 16.0 38.6 39.0 44.0 34.0 31.6 31.1 37.2 39.1 23.3 31.7 42.1 40.3 73.7 35.9 32.2 35.8 19.8 55.7 30.0 36.6 81.7 47.6 56.6 41.3 43.3 29.1 58.1 43.4 35.8 50.0 30.1 57.6 49.6 70.7 53.5 25.1 43.7 47.9 47.8 1108.9 46.8 55.9 32.4 54.9 55.1 22.7 38.6 89.4 46.1 45.2 43.0 62.0 45.8 28.4 34.6 49.1 36.4 32.3 21.4 22.0 37.5 44.5 22.9 41.9 44.8 46.9 24.9 46.4 38.1 44.7 30.7 18.9 34.2 15.9 21.4 17.2 21.5 18.3 15.6 19.9 19.3 18.9 14.4 27.6 22.3 19.9 19.5 25.8 14.9 21.7 30.6 29.7 23.8 20.6 24.5 31.3 28.0 30.4 27.9 27.1 38.6 22.1 19.2 17.7 22.9 21.5 16.3 28.9 61.7 31.3 22.3 28.8 27.7 41.1 28.6 34.4 25.8 12.5 43.0 27.4 48.7 49.0 37.9 80.8 35.6 37.3 21.4 10.3 34.9 18.5 36.3 32.5 26.0 18.8 45.8 52.6 21.2 17.5 41.1 33.0 26.9 22.1 36.4 40.7 27.7 16.2 125.0 32.6 25.2 7.2 16.9 34.1 24.9 25.7 26.2 67.2 44.5 41.8 34.6 21.5 40.9 57.2 68.8 24.5 21.0 39.5 28.2 27.2 33.1 44.2 44.5 21.6 44.5 21.4 27.5 34.3 27.1 STAMBPL1 "ALMalpha, AMSH-FP, AMSH-LP, bA399O19.2, FLJ31524, KIAA1373" ENSG00000138134 "STAM binding protein like 1" Q96FJ0 10 88879734-88975153 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 23.8" "Cell type enhanced" "Detected in many" "Early spermatids: 54.3;Excitatory neurons: 60.5;Microglial cells: 32.8;Spermatocytes: 40.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040202 Uncertain Approved "Plasma membrane" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 14: B-cells - Humoral immune response" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" "HPA040202: AB_10805708" "unprognostic (2.73e-1)" "unprognostic (1.95e-1)" "unprognostic (7.56e-2)" "unprognostic (4.25e-2)" "unprognostic (6.46e-2)" "unprognostic (6.27e-2)" "unprognostic (1.68e-2)" "unprognostic (1.05e-2)" "unprognostic (4.67e-2)" "unprognostic (8.20e-2)" "unprognostic (2.78e-1)" "unprognostic (6.57e-2)" "prognostic unfavorable (1.08e-5)" "unprognostic (4.41e-2)" "unprognostic (4.06e-2)" "unprognostic (1.50e-1)" "unprognostic (4.40e-3)" 3.9 23.8 5.5 10.4 6.5 5.3 2.5 2.6 9.0 2.7 0.0 8.7 6.4 4.2 0.9 4.4 2.2 4.1 8.0 6.2 1.4 1.8 1.8 3.6 16.2 1.1 0.5 12.7 2.3 3.4 5.5 1.2 2.6 1.7 9.7 4.4 1.4 1.1 0.7 3.7 7.3 3.0 1.9 7.2 5.1 18.0 0.5 7.1 1.2 1.5 12.2 6.4 2.5 5.6 14.8 16.5 1.0 0.6 14.4 27.7 0.0 31.5 28.9 19.0 16.3 0.3 25.6 18.6 2.3 15.6 12.3 6.4 4.1 4.5 17.9 16.3 10.8 4.6 10.4 0.9 10.3 20.2 5.7 10.6 1.4 31.6 9.6 18.4 0.6 20.9 0.0 7.3 50.0 3.0 34.2 21.5 6.6 13.3 14.1 3.4 13.0 3.8 6.5 4.7 9.6 11.9 3.7 1.1 37.5 3.6 2.3 4.1 4.9 17.0 12.4 20.7 19.9 17.7 19.7 17.2 18.2 19.4 16.9 9.5 1.0 8.1 10.7 1.1 14.1 17.7 15.5 13.7 1.7 14.9 16.6 10.0 1.4 23.6 0.5 27.9 28.3 8.0 5.5 6.5 2.6 9.0 6.2 1.4 1.1 0.5 2.6 1.9 0.5 5.6 2.3 0.0 4.5 10.7 16.7 9.6 5.3 1.4 1.2 3.6 2.3 1.4 8.6 0.0 0.2 5.5 0.0 0.1 18.8 7.6 0.0 1.3 54.3 1.9 6.5 1.8 9.1 3.4 60.5 1.8 0.1 7.7 3.1 1.4 5.1 7.4 1.8 2.4 3.7 6.7 26.2 9.3 4.1 1.3 9.6 20.7 7.2 3.1 0.0 32.8 1.0 9.3 12.3 26.2 1.9 1.9 2.8 1.5 14.2 1.9 7.9 0.8 5.0 0.4 0.0 20.4 6.4 40.2 2.5 5.9 11.4 0.1 17.6 14.9 14.2 2.9 SUPT16H "CDC68, FACT, FACTP140, FLJ10857, FLJ14010, SPT16/CDC68" ENSG00000092201 "SPT16 homolog, facilitates chromatin remodeling subunit" Q9Y5B9 14 21351476-21384019 "Enzymes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication, Host-virus interaction, Transcription, Transcription regulation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022551, HPA049787" Enhanced Supported "Nucleoplasm,Nucleoli fibrillar center" NA NA 27000 "Cluster 27: Non-specific - Gene expression" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "Nucleoli fibrillar center" "CAB022551: , HPA049787: AB_2680881" "unprognostic (1.65e-1)" "unprognostic (2.22e-1)" "unprognostic (3.52e-2)" "unprognostic (7.12e-2)" "unprognostic (7.32e-2)" "unprognostic (1.22e-2)" "unprognostic (1.38e-3)" "unprognostic (1.86e-1)" "unprognostic (7.65e-2)" "unprognostic (4.91e-2)" "unprognostic (1.09e-1)" "unprognostic (1.26e-1)" "unprognostic (6.48e-3)" "unprognostic (1.02e-1)" "unprognostic (7.58e-3)" "unprognostic (9.05e-2)" "unprognostic (5.87e-3)" 29.3 24.8 9.7 36.6 11.1 42.3 35.9 18.8 13.9 34.2 8.2 30.6 23.1 41.1 19.5 29.0 32.0 24.1 24.1 9.7 15.6 28.6 22.4 26.3 51.2 11.3 12.0 43.6 22.6 46.2 13.5 32.1 12.0 29.9 35.1 44.4 20.9 32.6 21.8 28.9 25.9 36.6 10.7 32.9 26.3 43.3 12.1 56.8 33.3 24.6 51.8 35.6 20.1 12.3 147.8 136.9 185.5 136.6 85.5 81.7 131.4 130.3 103.2 155.5 145.4 133.9 129.5 311.3 48.5 96.5 99.7 153.9 237.2 118.9 234.0 99.8 100.9 188.7 121.9 195.1 87.0 270.1 134.7 73.4 72.6 131.0 146.3 75.4 107.7 174.2 158.1 129.4 131.3 99.9 253.6 85.8 207.1 136.2 134.1 270.3 210.6 168.0 63.9 160.8 183.8 157.2 209.8 125.3 81.1 118.7 69.2 127.9 91.1 135.0 113.4 85.0 143.3 128.8 230.2 306.7 49.9 158.0 104.9 35.6 18.3 28.2 29.6 23.9 34.7 31.2 27.9 33.2 23.7 27.4 31.3 32.2 15.0 34.0 31.1 22.2 28.4 25.2 9.7 11.1 18.8 13.9 9.7 15.6 11.3 12.0 12.0 10.7 12.1 12.3 41.5 64.1 55.9 24.2 51.6 35.6 44.3 51.5 45.5 48.9 46.3 49.7 64.2 22.8 50.3 53.3 47.9 65.1 73.6 28.4 25.4 71.0 142.5 52.0 124.3 46.9 23.4 74.6 27.4 61.1 63.9 61.1 29.6 61.7 84.2 73.4 29.3 32.0 41.9 55.5 30.1 31.2 40.7 34.9 25.2 96.1 59.7 40.7 17.8 20.6 90.9 53.3 64.9 16.1 25.2 68.9 15.2 59.8 39.5 46.1 16.5 30.4 40.2 41.1 19.7 78.5 69.5 128.9 152.8 45.1 41.5 45.6 56.3 61.6 43.0 35.7 TFR2 "HFE3, TFRC2" ENSG00000106327 "Transferrin receptor 2" Q9UP52 7 100620416-100642779 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted membrane proteins, Transporters" Receptor "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 15 "liver: 346.1" "Group enriched" "Detected in some" 13 "Erythroid cells: 152.8;Hepatocytes: 455.7" "Cancer enriched" "Detected in many" 70 "liver cancer: 136.2" "Not detected" "Not detected" "Group enriched" "Detected in some" 22 "basophil: 2.5;eosinophil: 1.9" "Lineage enriched" "Detected in single" 25 "granulocytes: 2.5" "Group enriched" "Detected in some" 11 "HEL: 69.7;HMC-1: 92.7;K-562: 65.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB016255, HPA017171, HPA073125" Enhanced Approved "Golgi apparatus" NA NA 410000 "Cluster 46: Basophils - DNA binding" "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 1: K-562 - Erythropoiesis" "Cluster 15: Hepatocytes - Hemostasis" "Golgi apparatus" "CAB016255: AB_628395, HPA017171: , HPA073125: " "unprognostic (4.18e-2)" "unprognostic (1.97e-2)" "unprognostic (2.74e-1)" "unprognostic (1.04e-1)" "unprognostic (1.26e-2)" "unprognostic (4.13e-2)" "prognostic favorable (2.48e-4)" "unprognostic (2.29e-2)" "unprognostic (4.49e-2)" "unprognostic (9.26e-2)" "unprognostic (1.93e-1)" "unprognostic (2.90e-1)" "unprognostic (1.18e-9)" "unprognostic (6.51e-2)" "unprognostic (1.68e-1)" "unprognostic (3.28e-1)" "unprognostic (8.18e-2)" 0.0 0.1 0.0 0.0 0.0 22.5 0.0 0.6 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.1 0.0 0.0 346.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.2 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 6.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 69.7 0.0 7.2 0.0 1.6 92.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 65.8 0.0 0.0 0.0 0.0 0.1 0.1 0.4 0.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 2.5 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.3 2.1 0.3 0.9 0.4 0.0 8.5 0.3 0.6 1.2 10.0 0.8 0.0 8.4 0.1 1.7 0.1 0.0 0.4 5.8 0.1 0.6 1.2 0.0 152.8 5.4 0.2 1.1 0.5 1.5 0.2 0.0 0.2 7.1 455.7 0.3 21.9 5.4 0.3 0.0 8.6 1.7 8.4 0.0 0.4 0.0 1.0 0.2 0.4 6.2 1.5 0.7 0.1 0.1 0.0 0.4 0.6 0.1 0.1 0.3 1.9 0.0 0.4 0.7 0.7 2.9 0.2 0.6 0.1 2.6 0.1 0.6 0.5 TFRC "CD71, p90, TFR1" ENSG00000072274 "Transferrin receptor" P02786 3 196027183-196082096 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters" "Endocytosis, Host-virus interaction" "Host cell receptor for virus entry, Receptor, Transducer" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 254.5" "Cell type enhanced" "Detected in many" "Erythroid cells: 556.4;Syncytiotrophoblasts: 502.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 860.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000153, HPA028598" Enhanced Supported Endosomes,Lysosomes "Secreted to blood" NA NA 1310000000 38000000 "Cluster 27: Non-specific - Gene expression" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 36: HEL - Hemostasis" "Cluster 6: Erythroid cells - Oxygen transport" "Endosomes, Lysosomes" "CAB000153: AB_2533029, HPA028598: AB_10601599" "unprognostic (2.95e-2)" "prognostic unfavorable (3.67e-4)" "unprognostic (2.55e-1)" "unprognostic (1.48e-2)" "unprognostic (6.75e-2)" "unprognostic (7.88e-3)" "prognostic unfavorable (1.15e-4)" "unprognostic (6.92e-2)" "unprognostic (3.30e-3)" "unprognostic (4.35e-2)" "unprognostic (1.34e-2)" "unprognostic (1.14e-2)" "unprognostic (3.63e-3)" "unprognostic (3.65e-2)" "unprognostic (1.19e-2)" "prognostic unfavorable (2.96e-4)" "unprognostic (2.62e-2)" 44.6 28.7 21.6 63.4 18.3 254.5 20.2 18.5 32.3 31.3 15.7 77.2 35.9 23.8 11.1 36.0 25.9 24.9 31.0 21.9 19.0 26.4 27.8 78.0 23.0 24.2 19.9 93.9 15.9 44.8 13.1 103.2 26.3 13.2 55.6 47.3 15.7 13.4 76.2 21.8 32.1 31.5 20.8 15.5 21.4 21.6 25.3 22.0 20.1 68.7 28.1 68.5 17.4 20.7 175.3 155.0 69.8 142.1 151.7 87.3 438.7 242.5 183.7 168.1 276.3 384.6 156.6 178.5 446.3 91.0 363.5 261.8 243.3 81.1 204.2 860.4 82.4 677.4 120.2 179.2 119.4 561.8 130.4 99.1 78.6 144.5 129.0 47.8 56.9 95.6 287.3 164.1 132.8 161.7 185.8 116.8 214.9 228.6 314.0 97.3 103.9 214.1 148.3 435.3 159.3 65.9 234.4 613.9 55.2 115.9 595.0 115.8 72.5 198.4 159.7 175.3 369.7 46.3 387.8 276.7 232.3 149.2 122.3 0.0 1.6 2.2 2.2 7.3 1.4 5.1 2.4 1.5 3.5 3.1 2.1 1.7 0.2 1.9 13.2 7.1 6.4 2.1 21.6 18.3 18.5 32.3 21.9 19.0 24.2 19.9 26.3 20.8 25.3 20.7 25.4 44.8 32.1 43.1 46.6 60.3 37.2 33.6 21.1 53.1 37.1 34.9 103.0 41.5 38.8 20.2 148.0 122.5 53.2 156.6 0.0 49.4 3.5 35.3 20.3 23.6 56.1 556.4 24.7 41.8 25.3 32.4 77.5 56.1 23.4 40.2 8.6 93.2 73.4 13.5 28.3 67.8 22.4 37.1 77.6 5.3 11.5 161.7 17.8 44.0 49.4 22.0 9.2 11.6 8.2 52.0 50.8 8.6 42.1 25.6 48.3 13.1 32.1 44.4 26.3 36.3 29.3 23.8 18.2 51.3 35.8 502.7 42.6 16.6 103.5 23.7 THOP1 ENSG00000172009 "Thimet oligopeptidase 1" P52888 19 2785503-2815807 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 136.6;Paneth cells: 160.6;Proximal enterocytes: 312.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025497, HPA035262" Uncertain Supported Cytosol NA NA 2000000 "Cluster 18: Basophils - Vesicular transport" "Cluster 43: Testis - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 45: Enterocytes - Digestion" Cytosol "CAB025497: , HPA035262: AB_2674541" "unprognostic (1.52e-2)" "unprognostic (1.73e-3)" "unprognostic (7.94e-2)" "prognostic favorable (2.35e-4)" "unprognostic (1.82e-1)" "unprognostic (2.16e-2)" "unprognostic (9.35e-2)" "unprognostic (1.19e-1)" "unprognostic (4.05e-2)" "unprognostic (1.43e-1)" "unprognostic (1.20e-3)" "unprognostic (3.00e-2)" "unprognostic (1.39e-1)" "prognostic favorable (5.90e-4)" "unprognostic (1.27e-1)" "unprognostic (2.64e-1)" "unprognostic (5.37e-2)" 13.4 19.6 31.8 11.8 31.6 19.6 15.3 29.8 48.4 15.3 25.4 21.3 22.6 18.7 6.3 31.0 17.6 3.3 38.0 33.2 28.7 22.7 73.0 13.7 11.6 33.7 31.7 18.8 17.5 6.0 32.0 7.8 30.7 37.6 7.0 9.3 15.7 5.2 40.6 20.0 21.5 6.1 26.9 23.0 16.1 70.2 28.6 13.8 17.9 11.0 8.3 18.7 15.9 30.4 91.4 66.3 25.1 54.6 12.8 12.5 89.9 55.4 20.4 53.8 43.4 78.4 28.3 81.3 26.4 21.7 37.7 72.4 37.8 45.6 22.5 0.3 79.7 28.9 75.9 94.4 13.7 56.3 43.1 13.9 16.0 44.8 20.0 15.5 31.0 54.0 68.2 38.7 23.1 70.5 63.1 105.0 74.7 27.2 90.2 51.7 33.8 77.5 22.8 51.9 68.5 54.6 48.5 42.9 27.6 13.1 41.8 53.8 35.5 41.2 35.5 88.6 95.4 67.1 60.7 55.7 46.0 93.3 50.1 9.3 2.5 1.2 3.7 2.9 3.0 3.8 2.7 5.2 3.6 5.3 3.4 3.0 1.0 3.0 6.0 7.0 7.6 2.5 31.8 31.6 29.8 48.4 33.2 28.7 33.7 31.7 30.7 26.9 28.6 30.4 5.1 3.2 10.6 15.0 12.0 6.8 10.3 15.6 11.4 20.3 12.6 10.8 9.0 5.7 9.7 11.0 35.5 27.6 8.7 136.6 9.8 18.7 17.6 11.1 8.3 7.4 40.8 13.7 12.1 15.1 55.9 11.1 9.2 10.1 5.7 23.1 7.1 85.9 23.0 6.7 10.5 59.9 6.1 9.8 6.0 23.4 11.5 9.1 3.6 3.7 8.3 13.5 4.1 4.0 7.1 21.3 160.6 6.0 17.2 16.6 312.2 10.8 9.7 32.4 13.1 10.6 15.0 55.6 19.2 13.4 5.8 33.8 8.0 15.9 48.2 8.4 TINAG ENSG00000137251 "Tubulointerstitial nephritis antigen" Q9UJW2 6 54307859-54390142 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Cell adhesion" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 8 "kidney: 110.4" "Cell type enhanced" "Detected in some" "Distal enterocytes: 48.6;Distal tubular cells: 23.5;Proximal enterocytes: 72.5;Proximal tubular cells: 207.1" "Cancer enriched" "Detected in some" 4 "renal cancer: 15.8" "Group enriched" "Detected in some" 6 "medulla oblongata: 1.7;pons: 1.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 33 "RPTEC TERT1: 91.7" "Not detected" "Not detected" "Not detected" "Not detected" "HPA035427, HPA073753" Approved "Secreted to extracellular matrix" NA NA 40000 "Cluster 7: Kidney - Transmembrane transport" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA035427: AB_10601822, HPA073753: " "unprognostic (7.62e-3)" "unprognostic (1.12e-2)" "prognostic unfavorable (2.05e-5)" "unprognostic (7.27e-2)" "unprognostic (5.99e-3)" "prognostic favorable (8.75e-5)" "unprognostic (7.10e-2)" 0.0 0.0 0.1 0.8 0.1 0.0 0.0 0.0 0.2 0.0 0.0 14.0 11.7 0.0 0.0 0.0 0.0 1.7 0.1 0.2 0.0 110.4 0.0 0.0 0.0 1.7 0.1 0.0 0.0 0.0 0.0 0.0 1.6 0.0 13.8 0.0 0.0 0.0 0.2 0.0 14.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 91.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.2 0.2 0.0 1.7 0.1 1.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 7.3 0.0 0.0 0.0 48.6 23.5 0.0 1.0 0.1 0.0 0.0 9.7 0.0 2.8 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 6.6 0.0 0.0 0.0 0.1 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 15.3 0.0 0.0 0.0 72.5 207.1 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.3 0.0 18.4 0.0 TINAGL1 "ARG1, LCN7, LIECG3, P3ECSL, TINAGRP" ENSG00000142910 "Tubulointerstitial nephritis antigen like 1" Q9GZM7 1 31576485-31587686 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 1235.1;Sertoli cells: 427.3;Syncytiotrophoblasts: 1946.1" "Cancer enhanced" "Detected in all" "urothelial cancer: 87.8" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "basophil: 2.0" "Lineage enriched" "Detected in single" 4 "granulocytes: 2.0" "Cell line enhanced" "Detected in many" "BEWO: 322.7;CAPAN-2: 178.9;EFO-21: 403.6;HaCaT: 181.4;HBEC3-KT: 211.9;HUVEC TERT2: 173.4;TIME: 376.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA048695 Approved "Secreted to extracellular matrix" NA NA 370000 "Cluster 17: Basophils - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 38: EFO-21 - Unknown function" "Cluster 47: Cytotrophoblasts - Unknown function" "HPA048695: AB_2680497" "unprognostic (1.27e-1)" "unprognostic (2.94e-2)" "unprognostic (7.53e-2)" "unprognostic (1.80e-3)" "unprognostic (2.74e-1)" "unprognostic (1.72e-3)" "unprognostic (8.29e-3)" "unprognostic (6.02e-3)" "unprognostic (4.18e-1)" "unprognostic (6.96e-2)" "unprognostic (7.02e-3)" "unprognostic (1.22e-1)" "prognostic favorable (3.65e-6)" "unprognostic (7.42e-2)" "unprognostic (6.64e-2)" "prognostic favorable (9.64e-4)" "unprognostic (3.43e-2)" 173.7 40.8 19.0 18.5 17.7 0.9 150.5 17.9 19.9 86.8 16.4 83.2 26.7 101.8 10.7 31.0 82.4 23.9 230.7 15.2 17.9 177.7 22.7 85.7 8.5 19.6 18.3 38.8 31.0 13.2 25.3 183.6 19.8 71.2 16.5 1.0 63.8 40.6 46.6 37.0 51.6 36.5 16.4 119.6 66.4 6.2 21.2 3.8 115.1 30.6 5.3 88.4 70.2 17.1 96.6 0.2 0.0 0.5 0.8 0.2 322.7 14.9 1.9 0.7 0.4 44.5 178.9 0.2 403.6 13.4 7.0 181.4 0.2 211.9 0.1 0.7 0.1 0.1 7.3 11.5 4.5 0.1 0.5 0.2 37.9 0.0 7.6 0.1 173.4 0.1 2.4 0.4 0.0 0.0 0.7 0.6 0.9 52.6 6.1 0.4 0.1 0.4 57.0 72.6 0.4 0.5 38.0 125.6 4.2 18.8 7.5 0.3 376.6 0.3 91.6 0.7 2.8 0.4 0.5 1.6 0.2 0.2 3.3 2.0 0.1 0.1 0.2 0.0 0.1 0.1 0.1 0.1 0.0 0.3 0.2 0.2 0.8 0.4 0.1 0.1 0.1 0.0 19.0 17.7 17.9 19.9 15.2 17.9 19.6 18.3 19.8 16.4 21.2 17.1 345.4 9.6 5.8 0.7 2.7 11.0 121.5 244.1 8.0 0.0 32.0 73.0 46.7 37.1 28.6 132.4 0.0 1235.1 2.6 158.9 1.9 378.7 1.4 8.4 3.2 161.4 11.4 13.5 0.1 92.2 223.5 35.0 50.0 14.4 14.7 49.7 306.6 4.4 89.3 0.0 1.1 35.5 14.2 8.8 10.3 0.7 7.5 4.2 23.2 13.1 2.0 0.2 0.0 0.5 0.0 344.6 115.3 4.1 0.2 131.4 45.2 80.9 9.1 0.4 427.3 9.5 357.4 0.3 0.8 4.9 6.5 1946.1 3.8 2.7 59.7 219.4 TMPRSS11A "ECRG1, HATL1, HESP" ENSG00000187054 "Transmembrane serine protease 11A" Q6ZMR5 4 67909395-67964140 "Enzymes, Predicted membrane proteins, Transporters" "Cell cycle" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "esophagus: 86.1;lymphoid tissue: 28.4;vagina: 41.7" "Cell type enriched" "Detected in some" 7 "Squamous epithelial cells: 50.7" "Group enriched" "Detected in some" 9 "cervical cancer: 14.4;head and neck cancer: 11.6;lung cancer: 4.0" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA078316 Enhanced NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 61: Squamous epithelial cells - Keratinization" "HPA078316: " "unprognostic (1.63e-1)" "unprognostic (4.60e-2)" "unprognostic (1.76e-2)" "unprognostic (6.98e-2)" "unprognostic (1.98e-1)" "unprognostic (2.66e-1)" "unprognostic (4.58e-1)" "unprognostic (1.32e-1)" "unprognostic (4.36e-2)" "unprognostic (1.05e-1)" "unprognostic (3.50e-1)" "unprognostic (2.33e-2)" 0.0 0.0 0.3 0.0 0.3 0.0 0.0 0.0 1.3 19.9 0.0 0.0 0.0 0.0 0.0 86.1 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.9 0.4 0.0 0.0 0.0 0.1 0.0 1.1 0.3 0.0 0.4 12.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.3 0.1 0.0 0.0 28.4 0.3 41.7 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 1.3 0.2 0.3 0.9 0.4 1.1 0.1 0.3 0.7 0.0 0.0 0.0 1.3 0.0 0.0 0.3 0.5 1.2 0.6 0.0 0.0 0.5 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.0 0.0 0.1 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 3.3 0.0 0.0 0.0 0.0 1.4 0.0 0.1 0.0 0.0 0.0 0.1 0.0 3.5 0.7 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.9 0.0 0.3 0.1 0.1 0.2 50.7 0.0 0.0 0.0 0.0 0.0 7.2 TMPRSS11B HATL5 ENSG00000185873 "Transmembrane serine protease 11B" Q86T26 4 68226653-68245694 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "esophagus: 390.7;lymphoid tissue: 82.2;vagina: 118.3" "Group enriched" "Detected in some" 22 "Early spermatids: 10.4;Late spermatids: 14.5;Squamous epithelial cells: 8.2" "Group enriched" "Detected in some" 12 "cervical cancer: 2.6;head and neck cancer: 2.6;stomach cancer: 1.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 61: Squamous epithelial cells - Keratinization" "unprognostic (4.24e-2)" "prognostic favorable (6.91e-4)" "unprognostic (2.92e-1)" "unprognostic (3.96e-1)" 0.1 0.0 0.1 0.0 0.2 0.2 0.0 0.1 0.2 56.8 0.1 0.0 0.0 0.0 0.0 390.7 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.1 0.0 0.3 0.0 0.2 0.0 0.0 0.0 58.6 0.0 0.1 0.1 0.0 0.1 0.1 0.0 0.3 0.4 0.2 0.0 0.0 0.0 82.2 0.0 118.3 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.2 0.1 0.0 0.3 0.2 0.2 0.1 0.2 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.5 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 8.2 0.0 0.0 0.1 0.0 0.0 0.2 TMPRSS11D "ASP, HAT" ENSG00000153802 "Transmembrane serine protease 11D" O60235 4 67820876-67884002 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 19 "cervix: 51.6;esophagus: 71.8;lymphoid tissue: 34.4;salivary gland: 21.0;vagina: 76.0" "Cell type enhanced" "Detected in some" "Basal respiratory cells: 24.4;Club cells: 13.8;Inhibitory neurons: 3.9;Oligodendrocyte precursor cells: 5.0;Urothelial cells: 12.0" "Group enriched" "Detected in many" 5 "cervical cancer: 36.0;head and neck cancer: 30.0" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA077704 Enhanced "Intracellular and membrane" NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "HPA077704: " "unprognostic (1.19e-1)" "unprognostic (6.83e-2)" "unprognostic (8.82e-2)" "unprognostic (2.10e-2)" "unprognostic (1.21e-2)" "unprognostic (1.12e-1)" "unprognostic (3.22e-1)" "unprognostic (2.88e-1)" "unprognostic (1.32e-1)" "unprognostic (4.79e-1)" "unprognostic (4.38e-3)" "unprognostic (1.96e-1)" "unprognostic (6.91e-2)" "unprognostic (4.48e-2)" "unprognostic (2.19e-3)" 0.0 0.0 0.8 0.0 0.4 0.0 0.0 0.3 2.6 51.6 1.0 0.0 0.0 0.0 0.0 71.8 0.0 0.0 0.0 1.1 1.1 0.0 0.0 0.0 0.0 2.6 2.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.0 21.0 0.0 0.0 0.1 0.0 0.0 0.7 0.1 0.0 0.0 0.9 0.2 0.0 0.0 34.4 0.6 76.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.4 0.3 2.6 1.1 1.1 2.6 2.0 2.7 0.7 0.9 1.4 0.0 0.0 0.0 1.3 0.0 0.0 0.1 24.4 0.6 0.0 0.0 0.0 0.3 0.0 13.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 5.0 1.5 0.5 0.0 0.0 0.0 0.3 0.0 0.0 2.2 0.0 0.0 0.0 0.4 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 12.0 TMPRSS11E "DESC1, TMPRSS11E2" ENSG00000087128 "Transmembrane serine protease 11E" Q9UL52 4 68447463-68497604 "Enzymes, Predicted membrane proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "cervix: 89.5;esophagus: 220.2;salivary gland: 56.7;vagina: 156.3" "Cell type enriched" "Detected in some" 14 "Ionocytes: 476.0" "Group enriched" "Detected in many" 6 "cervical cancer: 22.0;head and neck cancer: 25.3;lung cancer: 11.5;urothelial cancer: 7.6" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HaCaT: 1.5;OE19: 1.6" "Not detected" "Not detected" "Not detected" "Not detected" "HPA043816, HPA051062" Enhanced Approved "Golgi apparatus" "Secreted in other tissues" NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Golgi apparatus" "HPA043816: , HPA051062: AB_2681329" "unprognostic (2.53e-1)" "unprognostic (3.10e-1)" "unprognostic (1.84e-1)" "unprognostic (9.14e-2)" "unprognostic (5.03e-2)" "prognostic unfavorable (6.73e-4)" "unprognostic (2.22e-1)" "unprognostic (9.70e-3)" "unprognostic (2.16e-1)" "unprognostic (3.74e-2)" "unprognostic (4.03e-2)" "unprognostic (8.39e-2)" "unprognostic (1.27e-1)" "unprognostic (3.08e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 89.5 0.0 0.0 0.0 0.0 18.2 220.2 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 2.2 0.0 0.0 56.7 0.7 0.0 3.2 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.1 0.0 0.0 24.5 6.5 156.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.5 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.4 12.9 0.7 0.0 0.0 0.5 0.3 0.3 0.0 2.8 0.0 0.0 0.0 0.3 0.0 0.0 0.3 6.5 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 476.0 0.0 0.3 1.4 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 2.2 0.0 0.0 0.2 0.0 0.0 0.0 0.3 0.1 0.2 6.6 0.3 1.1 0.7 0.0 0.0 32.6 TMPRSS11F "FLJ16046, HATL4" ENSG00000198092 "Transmembrane serine protease 11F" Q6ZWK6 4 68053198-68129869 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in some" "esophagus: 15.2;skin 1: 9.3;vagina: 4.8" "Cell type enriched" "Detected in some" 4 "Squamous epithelial cells: 6.9" "Group enriched" "Detected in some" 7 "cervical cancer: 1.6;head and neck cancer: 2.1;lung cancer: 0.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "K-562: 1.6" "Not detected" "Not detected" "Low region specificity" "Detected in single" HPA026911 Uncertain NA NA "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 1: K-562 - Erythropoiesis" "Cluster 61: Squamous epithelial cells - Keratinization" "HPA026911: AB_2205589" "unprognostic (9.46e-2)" "unprognostic (5.30e-1)" "unprognostic (7.16e-2)" "unprognostic (8.79e-3)" "unprognostic (1.09e-1)" "unprognostic (2.40e-1)" "unprognostic (1.22e-1)" "unprognostic (5.08e-2)" 0.0 0.0 0.1 0.0 0.1 0.0 1.1 0.0 0.3 2.2 0.0 0.0 0.0 0.0 0.0 15.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.1 0.0 0.2 0.5 0.1 0.0 0.1 1.0 0.0 0.1 9.3 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.0 0.0 4.1 0.0 4.8 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.3 0.0 0.1 0.3 0.1 0.5 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.3 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.4 6.9 0.0 0.3 0.0 0.1 0.0 0.5 TMPRSS12 "CT151, MGC57341" ENSG00000186452 "Transmembrane serine protease 12" Q86WS5 12 50842920-50887884 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 50 "testis: 21.6" "Group enriched" "Detected in some" 8 "Early spermatids: 44.7;Spermatocytes: 121.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 66: Spermatocytes - Spermatogenesis" "unprognostic (1.04e-1)" "unprognostic (9.09e-2)" "unprognostic (3.03e-2)" "unprognostic (7.25e-3)" "unprognostic (1.70e-1)" "unprognostic (1.39e-1)" "unprognostic (3.88e-1)" "unprognostic (2.98e-2)" "unprognostic (2.60e-1)" "unprognostic (1.88e-1)" "unprognostic (1.29e-1)" "unprognostic (5.65e-3)" "unprognostic (1.03e-2)" 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.4 0.2 0.0 0.3 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 21.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.3 0.1 0.0 0.0 0.7 0.0 0.3 0.5 0.2 0.0 0.0 0.8 0.5 0.1 0.0 0.1 1.8 0.0 0.9 0.1 0.0 0.0 0.0 44.7 0.1 0.0 0.0 0.0 0.0 0.6 0.0 1.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.7 0.0 0.0 0.0 0.0 9.7 4.1 0.1 1.8 0.0 0.0 0.0 0.0 2.0 0.6 0.0 0.0 0.7 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.1 121.7 2.4 0.0 0.3 0.7 0.0 0.0 0.0 0.1 TMPRSS13 "MSPL, MSPS, TMPRSS11" ENSG00000137747 "Transmembrane serine protease 13" Q9BYE2 11 117900641-117929459 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 15.7;skin 1: 41.0" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 15.9;Extravillous trophoblasts: 21.2;Glandular and luminal cells: 10.9;Ionocytes: 16.2;Syncytiotrophoblasts: 19.4" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 13.8;BEWO: 29.9;MCF7: 27.0;SK-BR-3: 42.8;T-47d: 43.5" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 6: T47d - Mammary gland" "Cluster 38: Extravillous trophoblasts - Unknown function" "unprognostic (1.08e-3)" "unprognostic (5.18e-2)" "unprognostic (6.59e-2)" "unprognostic (1.06e-3)" "unprognostic (1.04e-1)" "unprognostic (1.01e-1)" "unprognostic (3.64e-1)" "unprognostic (5.61e-2)" "unprognostic (1.20e-1)" "unprognostic (1.49e-1)" "unprognostic (1.92e-2)" "unprognostic (2.03e-1)" "unprognostic (3.16e-6)" "unprognostic (2.05e-1)" "unprognostic (7.75e-2)" "unprognostic (1.08e-1)" "unprognostic (3.44e-1)" 0.3 0.4 0.2 0.7 0.2 0.6 7.1 0.0 0.7 6.7 0.0 0.4 0.3 0.6 0.6 15.7 0.3 0.4 0.1 0.9 0.0 2.6 0.2 3.9 1.2 0.0 0.0 0.1 2.5 0.0 0.3 2.9 0.0 1.4 0.4 0.0 11.0 0.1 0.2 41.0 0.8 0.2 0.0 1.5 0.2 0.4 0.0 0.9 6.6 0.0 4.8 0.5 9.3 0.1 13.8 0.1 0.0 0.0 0.0 0.0 29.9 0.0 0.0 0.0 0.0 10.2 0.1 0.7 0.1 0.0 0.0 1.3 0.0 0.1 0.0 0.9 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.1 0.5 0.7 0.0 27.0 0.1 0.1 0.0 0.4 0.0 0.0 0.0 1.4 0.0 4.0 0.4 0.1 0.0 42.8 0.6 1.7 43.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.2 0.0 0.2 0.1 0.0 0.1 0.1 0.0 0.1 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.4 0.0 0.5 0.1 0.2 0.2 0.2 0.0 0.7 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 4.6 0.0 0.2 1.7 4.6 1.7 1.2 0.0 7.4 4.6 1.4 7.2 5.3 0.0 0.0 15.9 0.2 0.3 0.0 8.3 0.3 2.4 1.3 0.2 0.0 0.0 0.2 1.2 21.2 0.3 0.5 10.9 0.0 0.0 0.0 0.0 2.9 0.0 0.1 0.5 16.2 1.2 1.9 0.8 0.0 1.7 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.3 5.7 3.9 0.0 0.7 0.0 0.0 0.0 0.4 0.0 0.2 5.2 8.0 19.4 0.4 0.5 0.8 9.0 TMPRSS15 "ENTK, MGC133046, PRSS7" ENSG00000154646 "Transmembrane serine protease 15" P98073 21 18269116-18485879 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 512 "intestine: 979.8" "Cell type enriched" "Detected in some" 5 "Proximal enterocytes: 28.0" "Group enriched" "Detected in some" 12 "liver cancer: 0.7;pancreatic cancer: 1.5;stomach cancer: 1.5" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 19 "U-138 MG: 50.8;U-87 MG: 141.3" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "olfactory bulb: 5.0;spinal cord: 1.8" "HPA015611, HPA034857, HPA072934" Enhanced Approved "Plasma membrane" NA NA "Cluster 56: Intestine - Transmembrane transport" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 45: Enterocytes - Digestion" "Plasma membrane" "HPA015611: AB_1855791, HPA034857: , HPA072934: AB_2732214" "unprognostic (9.26e-2)" "unprognostic (4.14e-1)" "unprognostic (3.52e-1)" "unprognostic (8.33e-2)" "unprognostic (1.19e-1)" "unprognostic (7.20e-2)" "unprognostic (4.70e-2)" "unprognostic (6.35e-2)" "unprognostic (5.92e-2)" 0.0 0.0 0.9 0.2 0.7 0.0 0.0 1.9 1.7 0.0 0.0 0.2 979.8 0.2 0.0 0.1 0.0 0.1 0.1 0.7 0.6 0.0 0.0 0.0 0.7 0.2 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.2 21.8 0.0 0.0 0.0 0.4 1.0 0.4 0.0 0.2 0.0 0.0 0.0 0.0 1.4 0.0 0.3 0.0 0.2 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 1.8 0.2 0.1 0.2 0.2 0.0 0.0 0.0 0.0 0.0 4.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 3.9 0.0 0.0 0.0 0.1 4.9 0.0 0.0 0.0 0.4 0.1 0.1 0.0 0.3 0.0 4.6 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 50.8 0.0 0.3 0.0 0.9 0.0 0.2 141.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.9 0.7 1.9 1.7 0.7 0.6 0.2 0.6 0.1 0.0 0.4 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4 1.9 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 1.2 0.0 0.0 0.0 28.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.5 0.0 0.0 0.0 0.0 0.0 4.0 0.0 TMPRSS2 PRSS10 ENSG00000184012 "Transmembrane serine protease 2" O15393 21 41464300-41531116 "Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "prostate: 280.4;stomach 1: 146.2" "Cell type enhanced" "Detected in many" "Distal enterocytes: 404.8;Gastric mucus-secreting cells: 155.4;Paneth cells: 368.3;Prostatic glandular cells: 203.4;Proximal enterocytes: 159.6;Urothelial cells: 166.6" "Cancer enriched" "Detected in many" 7 "prostate cancer: 250.6" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CACO-2: 22.8;MCF7: 10.5;OE19: 35.9;RT4: 57.8;SK-BR-3: 11.7" "Not detected" "Not detected" "Low region specificity" "Detected in single" "HPA034493, HPA035787" Enhanced Supported "Plasma membrane" "Secreted in other tissues" NA NA "Cluster 4: Stomach - Digestion" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane" "HPA034493: , HPA035787: AB_2674782" "unprognostic (4.80e-3)" "unprognostic (3.49e-1)" "unprognostic (2.16e-1)" "prognostic favorable (2.56e-4)" "unprognostic (1.72e-1)" "unprognostic (1.05e-2)" "unprognostic (4.28e-2)" "unprognostic (1.51e-3)" "unprognostic (9.43e-2)" "unprognostic (9.02e-3)" "unprognostic (6.24e-2)" "unprognostic (6.43e-2)" "prognostic favorable (7.86e-6)" "unprognostic (2.00e-2)" "unprognostic (1.68e-1)" "unprognostic (1.41e-1)" "unprognostic (2.15e-2)" 0.6 0.2 0.4 13.9 0.4 0.1 20.1 0.2 0.4 5.0 3.1 104.0 78.5 1.0 2.8 36.1 10.7 24.1 0.2 0.3 0.3 47.7 33.5 39.9 0.2 0.4 0.3 0.2 111.4 4.0 1.5 0.2 0.3 280.4 78.0 0.2 76.2 7.7 0.1 7.3 89.6 3.3 0.1 0.2 146.2 1.5 0.3 0.8 19.2 0.1 10.2 35.7 7.6 0.5 0.1 0.0 0.1 0.0 0.1 0.1 2.3 0.0 0.0 0.1 0.1 22.8 3.3 0.1 0.4 0.1 0.1 0.1 0.0 0.0 0.1 0.2 0.0 0.0 0.1 3.7 0.0 0.0 0.3 0.0 0.1 0.1 0.0 0.0 0.3 0.0 0.1 0.1 0.0 10.5 0.3 1.0 2.3 35.9 0.2 0.1 0.0 2.6 1.3 57.8 0.2 0.7 0.3 11.7 0.3 0.4 8.8 0.0 0.0 0.1 0.6 0.6 0.1 0.0 0.2 0.7 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.4 0.2 0.4 0.3 0.3 0.4 0.3 0.3 0.1 0.3 0.5 0.1 51.3 109.8 0.0 1.7 0.3 30.9 6.8 0.0 0.0 34.0 25.8 0.6 32.9 42.1 47.8 0.0 0.7 1.1 404.8 23.5 39.2 21.3 7.4 0.5 1.3 18.0 2.7 0.2 60.4 0.1 1.0 155.4 5.8 7.0 0.0 0.4 32.0 0.1 0.0 0.1 84.1 44.7 0.3 0.3 4.8 0.0 2.0 10.6 0.0 0.6 0.0 0.0 0.0 0.0 65.1 368.3 0.0 0.0 203.4 159.6 3.8 36.6 0.0 0.0 1.6 2.0 0.4 1.4 2.1 0.1 0.3 1.1 0.0 105.7 166.6 TMPRSS3 "DFNB10, DFNB8" ENSG00000160183 "Transmembrane serine protease 3" P57727 21 42371887-42396091 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Hydrolase, Protease, Serine protease" "Cancer-related genes, Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "fallopian tube: 23.7;stomach 1: 14.5" "Cell type enhanced" "Detected in many" "Breast glandular cells: 17.7;Cholangiocytes: 24.3;Ductal cells: 16.1;Endometrial ciliated cells: 17.1;Gastric mucus-secreting cells: 23.4;Ionocytes: 16.2;Muller glia cells: 20.4;Respiratory ciliated cells: 39.8" "Cancer enhanced" "Detected in many" "ovarian cancer: 16.6" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "MAIT T-cell: 3.1" "Lineage enriched" "Detected in single" 6 "T-cells: 3.1" "Cell line enriched" "Detected in some" 4 "U-266/84: 274.7" "Not detected" "Not detected" "Low region specificity" "Detected in single" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 16: U-266 - Nucleosome" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "unprognostic (8.47e-3)" "unprognostic (2.83e-1)" "prognostic unfavorable (3.64e-4)" "unprognostic (2.85e-1)" "unprognostic (2.45e-3)" "unprognostic (3.97e-2)" "unprognostic (1.43e-1)" "unprognostic (8.17e-2)" "unprognostic (9.62e-2)" "unprognostic (4.81e-2)" "unprognostic (2.65e-1)" "unprognostic (1.42e-1)" "prognostic unfavorable (8.24e-4)" "unprognostic (2.66e-2)" "unprognostic (2.73e-1)" "unprognostic (8.00e-2)" "unprognostic (1.33e-1)" 0.5 0.3 3.8 0.2 4.0 0.1 8.7 4.0 3.7 6.3 2.0 0.2 1.3 0.7 0.0 0.2 23.7 8.6 0.0 3.4 4.1 2.4 0.5 3.4 0.5 4.9 4.7 0.0 3.0 0.0 1.5 0.2 3.7 0.4 0.1 3.9 9.2 0.4 0.1 0.1 1.1 0.0 3.5 0.4 14.5 0.0 4.7 0.9 2.9 0.0 0.4 1.0 0.0 2.7 4.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 12.5 0.0 0.7 0.0 0.3 0.0 0.0 0.0 0.0 32.9 0.0 66.2 26.5 0.7 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 8.6 0.0 14.0 0.0 1.5 3.5 0.0 0.0 1.0 0.4 0.0 0.0 0.0 2.8 1.5 0.0 0.0 33.9 1.6 0.0 0.0 3.2 0.3 0.1 0.0 1.7 0.0 0.2 0.7 274.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.1 3.1 0.0 1.7 1.8 0.0 0.0 0.3 0.9 0.3 0.0 0.5 0.0 0.8 0.5 3.8 4.0 4.0 3.7 3.4 4.1 4.9 4.7 3.7 3.5 4.7 2.7 0.1 12.8 3.7 2.3 0.4 0.3 2.3 8.1 0.0 0.2 17.7 9.9 0.6 24.3 10.8 7.3 0.0 0.0 0.1 1.4 5.9 16.1 1.4 17.1 0.4 0.2 0.0 2.7 0.0 13.8 0.1 1.3 23.4 5.2 0.0 0.2 0.4 0.0 0.1 0.0 0.0 2.0 16.2 0.0 0.5 0.6 0.3 0.3 0.0 0.0 0.0 20.4 0.0 0.0 0.1 11.8 1.4 0.0 0.4 2.4 2.9 0.0 39.8 0.9 0.0 0.0 0.7 0.0 0.0 0.0 0.1 0.0 1.4 0.1 2.5 5.0 TMPRSS4 "MT-SP2, TMPRSS3" ENSG00000137648 "Transmembrane serine protease 4" Q9NRS4 11 118077012-118121890 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 108.7;intestine: 43.5;urinary bladder: 74.6" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 101.7;Club cells: 103.5;Distal enterocytes: 187.9;Squamous epithelial cells: 119.2;Urothelial cells: 258.6" "Low cancer specificity" "Detected in many" "Region enriched" "Detected in single" 5 "cerebellum: 1.8" "Immune cell enriched" "Detected in single" 7 "basophil: 2.1" "Lineage enriched" "Detected in single" 10 "granulocytes: 2.1" "Group enriched" "Detected in some" 5 "CAPAN-2: 103.7;HaCaT: 39.2;OE19: 141.6;RPTEC TERT1: 70.6;RT4: 95.9" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA006238 Uncertain "Secreted in other tissues" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "HPA006238: AB_1080316" "unprognostic (1.48e-1)" "unprognostic (3.27e-2)" "unprognostic (1.19e-2)" "unprognostic (1.23e-1)" "unprognostic (5.23e-2)" "unprognostic (5.50e-2)" "unprognostic (8.17e-3)" "unprognostic (1.95e-2)" "unprognostic (2.41e-1)" "unprognostic (9.62e-2)" "prognostic unfavorable (3.14e-4)" "unprognostic (2.87e-3)" "unprognostic (2.80e-1)" "unprognostic (4.58e-2)" "unprognostic (1.06e-1)" "unprognostic (1.10e-2)" "unprognostic (9.96e-3)" 0.2 0.0 0.1 6.1 0.1 0.8 0.3 1.8 0.3 16.6 0.3 43.5 25.4 2.1 3.2 108.7 1.0 14.3 0.2 0.1 0.0 21.1 0.2 1.4 0.2 0.1 0.0 0.1 0.3 0.0 0.2 0.1 0.2 7.8 42.9 0.4 6.5 0.2 0.2 4.1 22.4 1.5 0.0 0.2 31.4 1.1 0.2 1.1 0.2 0.1 14.9 74.6 16.7 0.3 18.5 0.1 0.1 0.2 0.0 0.0 0.7 0.0 0.0 0.0 0.0 2.7 103.7 0.1 3.5 0.0 0.1 39.2 0.0 0.4 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.1 0.0 3.4 0.3 0.0 1.3 0.3 4.5 0.1 141.6 0.0 0.1 0.1 0.2 70.6 95.9 0.1 0.1 0.0 8.4 0.1 0.2 0.5 0.1 0.1 0.2 0.1 0.0 0.1 0.3 0.1 0.1 0.1 0.1 0.1 2.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.1 0.1 1.8 0.3 0.1 0.0 0.1 0.0 0.2 0.0 0.2 0.3 0.1 0.0 1.7 0.0 0.4 1.1 35.2 101.7 38.1 0.0 0.0 0.0 0.7 0.0 103.5 11.0 0.0 0.2 0.0 187.9 0.0 1.5 3.0 45.3 4.6 0.8 4.2 0.0 0.2 7.3 3.0 0.5 53.5 66.4 5.7 0.0 0.0 0.1 0.2 0.0 0.2 55.3 34.6 0.3 0.3 2.5 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 52.6 67.5 0.0 2.7 17.5 55.2 2.4 69.4 0.0 0.0 0.0 4.7 0.0 0.1 119.2 6.3 0.3 0.5 0.0 71.2 258.6 TMPRSS5 "MGC141886, MGC148044" ENSG00000166682 "Transmembrane serine protease 5" Q9H3S3 11 113687547-113706373 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 50.6;choroid plexus: 20.8" "Cell type enhanced" "Detected in some" "Astrocytes: 26.4;Excitatory neurons: 5.4;Horizontal cells: 5.0;Oligodendrocytes: 15.5" "Cancer enhanced" "Detected in some" "glioma: 5.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 2.0;CAPAN-2: 3.2;OE19: 2.0;WM-115: 2.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA010992 Approved Nucleoplasm NA NA "Cluster 70: Brain - Nervous system development" "Cluster 17: WM-115 - Nervous system development" "Cluster 64: Astrocytes - Nervous system maintenance" Nucleoplasm "HPA010992: AB_1858152" "unprognostic (1.53e-2)" "unprognostic (3.81e-2)" "unprognostic (2.97e-1)" "unprognostic (1.05e-1)" "unprognostic (1.93e-1)" "unprognostic (8.73e-2)" "unprognostic (2.99e-3)" "unprognostic (3.08e-1)" "unprognostic (5.19e-3)" "unprognostic (8.49e-2)" "unprognostic (8.13e-2)" "unprognostic (3.38e-2)" "unprognostic (1.96e-3)" "unprognostic (1.18e-1)" "unprognostic (1.75e-1)" "unprognostic (1.80e-1)" "unprognostic (4.04e-3)" 1.3 0.5 28.1 0.2 34.7 1.4 2.0 24.9 39.0 0.8 20.8 0.7 0.1 0.5 0.2 0.5 0.7 0.7 1.0 28.2 27.0 1.0 1.0 0.7 0.2 34.0 29.8 0.6 0.5 0.0 1.6 0.2 33.1 0.8 0.3 1.1 9.6 0.3 2.6 2.1 0.7 0.3 28.5 0.8 0.8 2.1 32.1 0.3 0.6 0.5 0.3 0.7 1.0 50.6 0.2 0.3 2.0 1.1 0.2 0.1 0.3 0.5 0.2 0.3 0.4 1.1 3.2 0.1 1.4 0.2 0.3 0.4 0.1 0.2 0.1 0.2 0.6 0.4 0.3 0.0 0.1 0.5 0.4 0.2 0.2 0.2 0.5 0.2 0.3 0.7 0.4 0.2 0.4 0.0 0.4 0.6 0.2 2.0 0.1 0.4 0.2 0.0 0.3 0.2 0.3 0.4 0.2 0.0 1.6 0.2 0.2 0.2 0.2 0.4 0.7 0.3 0.3 0.2 0.1 0.0 0.1 0.4 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 28.1 34.7 24.9 39.0 28.2 27.0 34.0 29.8 33.1 28.5 32.1 50.6 0.2 0.0 0.0 26.4 0.2 0.3 0.2 0.0 0.0 0.5 1.0 0.9 0.5 0.0 0.1 1.8 2.1 0.0 0.2 0.2 0.0 0.3 0.1 0.3 0.2 0.3 0.0 1.3 5.4 0.9 0.0 0.3 0.0 0.4 0.0 0.4 0.4 0.2 0.1 5.0 2.8 0.0 0.0 0.0 0.3 0.3 0.3 0.1 0.0 2.8 0.1 3.2 0.0 3.5 15.5 0.6 0.0 0.0 0.3 0.2 0.0 0.0 0.1 1.3 0.0 0.5 0.1 1.0 0.4 0.0 0.0 0.0 0.0 0.1 0.1 0.2 TMPRSS6 "FLJ30744, MT2" ENSG00000187045 "Transmembrane serine protease 6" Q8IU80 22 37065436-37109713 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 10 "liver: 128.4" "Group enriched" "Detected in some" 11 "Early spermatids: 61.0;Hepatocytes: 99.9;Late spermatids: 143.9" "Group enriched" "Detected in many" 14 "liver cancer: 51.3;thyroid cancer: 14.1" "Group enriched" "Detected in some" 4 "basal ganglia: 4.4;thalamus: 1.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "Hep G2: 5.0;SCLC-21H: 8.1" "Not detected" "Not detected" "Region enhanced" "Detected in single" "basal ganglia: 3.3" NA NA "Cluster 62: Liver - Hemostasis" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 31: Spermatids - Spermatogenesis" "unprognostic (3.93e-1)" "unprognostic (3.28e-1)" "unprognostic (8.62e-2)" "unprognostic (6.29e-5)" "unprognostic (7.95e-2)" "unprognostic (1.62e-1)" "prognostic favorable (8.16e-6)" "unprognostic (2.44e-1)" "unprognostic (3.07e-1)" "unprognostic (2.41e-1)" "unprognostic (1.16e-2)" "unprognostic (3.58e-2)" "unprognostic (1.15e-7)" "unprognostic (2.38e-1)" "unprognostic (9.15e-2)" "unprognostic (2.39e-2)" "unprognostic (3.86e-5)" 0.1 0.1 0.2 0.2 4.4 0.2 0.4 0.1 0.6 0.1 0.0 0.6 2.2 0.1 0.8 0.2 0.5 0.9 0.0 0.2 0.2 0.1 128.4 0.7 0.3 0.2 0.4 0.1 1.3 0.0 13.0 0.7 0.2 0.2 0.5 0.1 0.0 0.0 0.0 2.2 1.0 0.0 0.0 0.2 3.6 7.7 1.3 0.4 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.6 0.1 0.3 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.2 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.3 1.5 0.2 0.1 5.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.7 0.0 0.3 0.0 0.9 0.0 0.0 0.2 0.1 0.1 0.3 0.1 0.2 0.0 0.0 8.1 0.3 0.1 0.6 0.0 0.1 0.1 0.0 0.4 0.3 1.0 0.1 0.0 1.0 0.3 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 4.4 0.1 0.6 0.2 0.2 0.2 0.4 0.2 0.0 1.3 0.1 0.0 0.0 0.0 0.3 0.6 0.5 0.0 0.0 0.0 0.0 0.6 0.3 0.5 2.8 0.0 0.0 0.0 0.0 0.1 8.8 0.0 0.2 61.0 0.0 0.0 0.3 5.3 8.0 0.1 0.0 2.6 0.0 2.6 0.0 0.0 0.0 2.5 99.9 0.1 0.0 0.1 1.5 0.0 3.2 0.0 143.9 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.6 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.8 0.0 0.1 0.3 0.3 0.1 0.6 0.0 TMPRSS7 ENSG00000176040 "Transmembrane serine protease 7" Q7RTY8 3 112034843-112081269 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in single" "testis: 1.4" "Cell type enhanced" "Detected in some" "Basal prostatic cells: 4.3;Early spermatids: 6.0;Excitatory neurons: 4.0;Respiratory ciliated cells: 8.1;Urothelial cells: 3.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected" "Not detected" HPA040630 Uncertain NA NA "Cluster 49: Ciliated cells - Cilium organization" "Cluster 49: Ciliated cells - Cilium organization" "HPA040630: AB_10796124" "unprognostic (4.02e-2)" "unprognostic (9.87e-2)" "unprognostic (9.05e-2)" "unprognostic (2.16e-2)" "unprognostic (2.24e-1)" "unprognostic (4.64e-3)" "unprognostic (6.63e-2)" "unprognostic (2.16e-1)" "unprognostic (2.29e-2)" "unprognostic (4.64e-1)" "unprognostic (1.68e-1)" "unprognostic (1.94e-1)" "unprognostic (7.23e-2)" "unprognostic (2.96e-1)" "unprognostic (2.06e-2)" 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.3 0.3 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.2 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.2 0.0 0.2 1.4 0.1 0.2 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.3 0.3 0.2 0.1 0.1 0.1 0.1 0.2 0.1 0.3 0.0 0.0 0.0 0.3 0.0 0.5 4.3 0.6 0.0 0.0 0.5 0.0 0.3 0.0 1.9 0.0 0.0 0.6 0.0 1.6 0.0 0.2 6.0 1.3 0.1 0.4 0.0 0.0 4.0 0.2 0.1 0.2 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 1.4 1.5 0.0 0.0 0.7 2.2 0.0 0.1 0.0 0.0 0.1 0.0 1.0 0.0 0.1 0.4 2.2 0.0 0.0 1.6 2.6 0.0 8.1 0.0 0.0 0.3 0.5 0.7 0.2 0.0 0.9 0.8 0.4 0.1 0.2 3.0 TMPRSS9 ENSG00000178297 "Transmembrane serine protease 9" Q7Z410 19 2360238-2426239 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "liver: 4.1;lymphoid tissue: 2.4;testis: 3.7" "Cell type enhanced" "Detected in some" "Early spermatids: 23.4;Erythroid cells: 48.6;Granulosa cells: 22.1;Late spermatids: 59.9;Theca cells: 41.0" "Cancer enhanced" "Detected in some" "liver cancer: 1.5;melanoma: 1.4" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "Karpas-707: 2.2;SK-BR-3: 1.2;U-266/70: 2.2" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA051483 Uncertain NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 29: U-266 - Adaptive immune response" "Cluster 6: Erythroid cells - Oxygen transport" "HPA051483: AB_2681501" "unprognostic (1.63e-1)" "unprognostic (1.94e-2)" "unprognostic (5.62e-3)" "unprognostic (1.86e-1)" "unprognostic (1.54e-2)" "unprognostic (1.87e-3)" "unprognostic (3.30e-1)" "unprognostic (6.44e-2)" "unprognostic (7.29e-2)" "unprognostic (2.07e-1)" "unprognostic (6.30e-2)" "unprognostic (9.20e-3)" "unprognostic (2.28e-3)" "unprognostic (8.67e-2)" "unprognostic (1.96e-1)" "unprognostic (3.07e-3)" "unprognostic (6.73e-2)" 0.1 0.7 1.5 0.1 0.5 0.8 0.4 0.7 1.3 0.0 0.0 0.3 0.1 0.2 0.0 0.0 0.1 0.1 0.0 0.4 0.2 0.0 4.1 0.0 0.1 0.6 0.4 0.2 0.7 0.0 0.1 0.0 0.7 0.1 0.0 0.1 0.2 0.0 0.6 0.5 0.1 0.0 0.1 2.4 0.1 3.7 0.6 0.2 0.0 0.0 0.0 0.1 0.0 0.3 0.6 0.1 0.0 0.1 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.1 0.1 0.1 0.2 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.3 0.1 0.9 0.9 0.0 0.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.4 2.2 0.0 0.3 0.0 0.1 0.2 0.0 0.3 0.4 0.0 0.3 0.0 0.1 0.0 0.1 0.1 1.2 0.0 0.1 0.1 0.7 0.1 0.3 0.3 0.3 0.3 2.2 0.5 0.4 0.1 0.3 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.5 0.5 0.7 1.3 0.4 0.2 0.6 0.4 0.7 0.1 0.6 0.3 0.2 0.0 0.0 1.3 0.3 0.0 0.1 0.0 0.0 0.7 0.2 0.9 1.4 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 23.4 0.2 0.5 0.1 0.0 48.6 2.4 0.0 0.1 0.5 0.0 0.9 0.0 22.1 0.7 4.8 0.2 0.0 2.1 0.0 0.0 0.0 0.3 59.9 0.9 0.4 0.0 0.0 0.1 0.1 0.0 2.5 2.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.2 11.0 3.5 0.0 0.0 0.5 0.1 41.0 0.0 0.0 TNFAIP3 "A20, OTUD7C" ENSG00000118503 "TNF alpha induced protein 3" P21580 6 137867214-137883312 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Inflammatory response, Ubl conjugation pathway" "DNA-binding, Hydrolase, Multifunctional enzyme, Protease, Thiol protease, Transferase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 519.5" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 774.9;Endometrial ciliated cells: 605.2;Glandular and luminal cells: 1498.3;Macrophages: 596.6;Suprabasal keratinocytes: 745.7;T-cells: 624.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "GAMG: 106.5;Karpas-707: 161.3;REH: 151.5;U-266/84: 131.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002116 Approved Approved Centrosome,Cytosol NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 2: Karpas-707 - Immune response" "Cluster 41: Macrophages - Immune response" "Centrosome, Cytosol" "HPA002116: AB_1858162" "unprognostic (5.50e-3)" "unprognostic (9.98e-3)" "unprognostic (3.06e-2)" "unprognostic (1.01e-2)" "unprognostic (4.01e-2)" "unprognostic (9.47e-2)" "unprognostic (5.01e-3)" "unprognostic (4.40e-2)" "unprognostic (2.92e-2)" "unprognostic (2.58e-1)" "unprognostic (1.72e-1)" "unprognostic (2.06e-1)" "prognostic unfavorable (6.05e-4)" "unprognostic (6.06e-2)" "unprognostic (3.55e-3)" "unprognostic (1.27e-1)" "unprognostic (6.29e-2)" 57.0 15.6 4.4 114.6 3.8 519.5 23.3 2.9 23.9 27.5 12.0 22.6 21.4 31.3 5.2 26.6 23.4 47.8 23.0 3.2 2.8 13.8 27.4 56.2 76.8 6.1 3.9 73.2 25.8 25.8 7.5 28.9 6.7 17.3 24.7 19.1 16.1 10.3 8.6 50.5 30.7 33.5 6.6 46.1 22.8 8.3 9.5 71.1 11.7 3.8 55.7 171.1 14.6 6.2 32.6 4.8 1.8 2.8 10.1 16.9 7.8 18.8 67.6 4.8 5.7 34.9 8.8 7.3 43.1 20.0 106.5 22.6 1.1 50.4 8.9 46.8 2.2 7.5 19.8 21.1 11.2 10.3 12.8 15.6 7.3 56.4 53.6 5.6 2.9 21.2 17.4 161.3 8.4 1.8 56.2 41.4 1.5 2.1 1.4 151.5 39.4 6.1 14.8 15.1 0.7 0.3 3.6 5.3 16.9 7.0 3.4 11.7 14.8 46.9 6.8 46.0 9.6 48.7 131.4 14.0 16.9 13.1 6.1 7.3 12.6 9.6 19.6 9.3 27.9 7.4 19.4 18.0 14.3 7.8 13.1 10.1 13.6 11.1 5.1 26.2 19.2 14.8 4.4 3.8 2.9 23.9 3.2 2.8 6.1 3.9 6.7 6.6 9.5 6.2 71.8 38.5 76.3 2.0 94.5 774.9 150.2 102.1 384.7 1.1 29.0 42.3 4.6 25.8 53.7 0.0 29.2 8.1 395.5 53.9 1.9 60.0 2.6 605.2 365.9 114.8 11.9 5.2 0.1 26.9 104.8 110.1 111.1 1498.3 255.9 2.3 48.5 13.5 45.7 0.0 0.3 38.6 67.1 125.2 461.8 3.2 6.8 596.6 129.9 8.4 59.1 1.7 14.4 2.0 0.3 30.5 29.5 6.0 331.4 170.2 37.3 3.1 84.3 13.3 6.6 29.0 94.9 2.7 2.2 367.9 745.7 23.1 624.2 14.9 20.9 78.1 TPP2 TPPII ENSG00000134900 "Tripeptidyl peptidase 2" P29144 13 102596986-102679958 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 9 "Early spermatids: 796.3;Late spermatids: 892.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021069, HPA049630" Approved Supported "Nuclear bodies,Cytosol" NA NA 280000 "Cluster 39: Non-specific - mRNA processing" "Cluster 23: Testis - Cell cycle regulation" "Cluster 32: U-937 - Innate immune response" "Cluster 25: Spermatids - Spermatogenesis" "Nuclear bodies, Cytosol" "HPA021069: AB_1858344, HPA049630: AB_2680836" "unprognostic (4.75e-2)" "unprognostic (4.78e-2)" "unprognostic (9.97e-2)" "unprognostic (1.08e-1)" "unprognostic (2.01e-2)" "unprognostic (4.43e-2)" "unprognostic (2.45e-2)" "unprognostic (8.33e-3)" "unprognostic (5.02e-2)" "unprognostic (1.51e-1)" "unprognostic (3.12e-1)" "unprognostic (2.75e-3)" "unprognostic (6.26e-2)" "unprognostic (3.12e-1)" "unprognostic (7.53e-2)" "unprognostic (3.95e-2)" "unprognostic (3.43e-3)" 12.6 8.1 3.5 15.6 5.5 48.0 16.4 9.7 5.3 12.9 5.7 13.9 12.3 16.3 19.7 11.6 11.5 12.5 13.8 3.0 2.3 10.0 20.4 14.6 19.9 3.7 3.1 14.1 10.9 11.3 8.3 17.7 4.4 11.3 19.2 17.4 10.6 16.7 27.7 12.1 12.5 13.1 3.3 18.6 12.2 51.8 4.9 16.1 19.9 22.1 17.1 12.8 11.4 9.8 33.8 13.7 38.0 28.7 28.9 37.5 25.5 34.9 26.6 23.8 28.0 30.7 41.0 37.3 11.9 30.3 25.7 30.0 30.5 23.7 39.3 26.4 24.9 71.2 34.0 22.8 22.9 89.3 44.6 31.5 11.2 26.4 35.6 23.6 32.7 34.8 43.4 42.9 32.0 11.3 37.2 53.4 28.5 43.7 17.6 43.5 30.3 31.8 25.7 29.7 35.8 26.7 23.2 35.0 13.7 31.9 20.0 79.9 28.5 20.9 15.1 12.9 29.0 40.7 56.2 37.0 31.1 56.6 26.8 7.4 5.5 3.7 7.1 5.9 8.4 4.8 8.2 8.4 5.2 4.5 9.7 9.8 1.0 8.9 4.9 3.3 9.6 4.5 3.5 5.5 9.7 5.3 3.0 2.3 3.7 3.1 4.4 3.3 4.9 9.8 20.9 38.5 41.6 41.8 24.5 15.4 16.4 10.6 22.8 27.5 18.5 12.7 41.8 11.5 18.5 14.7 73.0 28.5 38.7 13.3 9.8 19.8 796.3 23.0 28.9 19.3 19.8 26.1 64.1 8.8 30.7 25.8 14.3 22.7 38.6 24.8 20.3 22.4 32.1 8.4 69.8 18.5 8.2 25.7 19.9 892.8 32.0 29.5 17.8 65.6 29.3 13.8 42.2 66.4 67.3 13.3 16.3 18.8 58.9 16.5 10.2 13.2 36.4 46.5 26.3 24.3 28.8 92.7 30.0 22.9 13.4 33.1 35.6 31.6 21.8 19.6 TPSAB1 "TPS1, TPS2, TPSB1" ENSG00000172236 "Tryptase alpha/beta 1" Q15661 16 1240379-1242554 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in some" 13 "granulocytes: 5873.9" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 893 "basophil: 89.3" "Lineage enriched" "Detected in single" 893 "granulocytes: 89.3" "Cell line enriched" "Detected in some" 166 "HMC-1: 3813.2" "CAB016369, CAB022175, HPA049153, HPA049554" Supported "Secreted to blood" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 3: HMC-1 - Innate immune response" "Cluster 60: Granulocytes - Receptor signaling" "CAB016369: AB_628406, CAB022175: , HPA049153: AB_2680656, HPA049554: AB_2680815" "unprognostic (2.06e-2)" "unprognostic (5.14e-2)" "unprognostic (2.02e-3)" "unprognostic (1.64e-2)" "unprognostic (9.31e-3)" "prognostic favorable (9.62e-6)" "unprognostic (1.02e-1)" "unprognostic (4.08e-2)" "unprognostic (1.80e-1)" "unprognostic (1.43e-1)" "unprognostic (2.24e-1)" "unprognostic (2.83e-2)" "unprognostic (4.13e-2)" "unprognostic (2.23e-1)" "unprognostic (2.81e-2)" "unprognostic (1.16e-1)" "unprognostic (1.36e-2)" 96.6 2.9 0.3 23.6 0.5 2.4 47.2 0.3 0.9 53.7 0.9 83.0 71.6 73.3 6.0 64.3 26.6 129.7 14.7 0.4 0.4 13.9 12.2 128.5 21.3 0.4 0.3 3.2 18.9 2.3 3.5 1.2 0.6 65.9 34.6 0.0 60.2 22.5 10.1 122.7 148.7 17.9 0.4 5.9 104.0 8.9 0.4 14.2 4.7 13.0 13.2 113.5 52.6 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 2.7 0.0 0.0 0.0 0.0 0.0 19.3 0.0 0.0 0.0 1.3 3813.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.7 0.0 0.3 2.1 6.1 0.5 0.4 0.0 0.4 0.0 0.5 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.5 0.1 1.1 0.0 0.0 2.8 22.9 2.0 89.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.3 0.5 0.3 0.9 0.4 0.4 0.4 0.3 0.6 0.4 0.4 0.3 0.0 25.6 135.5 0.0 2.9 18.6 5.1 0.0 1.2 0.0 0.9 0.1 0.3 0.0 8.1 0.0 0.0 0.0 0.2 0.9 0.0 1.2 0.3 0.0 0.0 4.1 0.0 3.8 0.0 0.0 0.2 7.6 0.5 0.0 5873.9 0.0 0.0 0.3 5.2 0.0 0.0 0.0 0.0 0.3 25.6 0.2 0.0 7.7 19.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 11.7 4.0 0.4 0.1 5.1 0.0 0.0 0.3 3.2 0.0 0.1 0.1 9.9 0.3 440.9 0.0 0.5 5.6 TPSB2 ENSG00000197253 "Tryptase beta 2" P20231 16 1227272-1230184 "Enzymes, Metabolic proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in some" 25 "granulocytes: 8966.1" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 50 "basophil: 5.0" "Lineage enriched" "Detected in single" 50 "granulocytes: 5.0" "Cell line enriched" "Detected in some" 7 "HMC-1: 297.5" "HPA049153, HPA049554" Supported "Secreted to blood" NA NA 16000000 "Cluster 10: Basophils - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 3: HMC-1 - Innate immune response" "Cluster 60: Granulocytes - Receptor signaling" "HPA049153: AB_2680656, HPA049554: AB_2680815" "unprognostic (9.05e-2)" "unprognostic (8.46e-3)" "unprognostic (2.42e-3)" "unprognostic (2.27e-2)" "unprognostic (4.97e-3)" "unprognostic (1.02e-3)" "unprognostic (1.11e-1)" "unprognostic (8.55e-2)" "unprognostic (2.48e-1)" "unprognostic (2.24e-1)" "unprognostic (1.95e-1)" "unprognostic (8.30e-3)" "unprognostic (1.91e-2)" "unprognostic (5.76e-2)" "unprognostic (2.41e-2)" "unprognostic (4.65e-2)" "unprognostic (3.17e-2)" 95.1 2.5 0.3 20.2 0.6 4.3 47.8 0.3 0.9 53.2 1.0 77.8 35.5 71.8 9.8 64.6 30.4 103.9 15.0 0.5 0.5 15.5 12.2 127.8 26.2 0.5 0.4 3.5 18.9 1.5 3.9 1.3 0.5 67.0 19.8 0.0 64.5 13.3 10.0 122.5 146.1 22.0 0.5 5.2 102.1 9.9 0.5 4.9 4.7 10.4 9.9 118.6 53.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.0 41.2 0.0 0.0 0.2 0.4 297.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.3 4.7 0.3 1.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.4 0.0 0.7 5.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.6 0.3 0.9 0.5 0.5 0.5 0.4 0.5 0.5 0.5 0.3 0.1 38.5 275.3 0.0 2.8 0.0 4.4 0.0 0.0 0.0 1.5 0.0 1.5 0.0 16.7 0.0 0.0 0.1 0.6 0.7 0.0 2.4 0.6 0.0 0.0 3.2 0.0 18.9 0.0 0.0 0.2 6.0 2.0 0.0 8966.1 0.0 0.0 0.0 3.8 0.0 0.1 0.7 0.0 0.0 0.0 1.0 0.0 11.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 25.8 5.4 0.7 0.1 3.6 0.0 0.0 0.4 1.1 0.0 0.7 0.0 0.0 0.1 345.1 0.0 1.0 6.1 TPSD1 ENSG00000095917 "Tryptase delta 1" Q9BZJ3 16 1256059-1259008 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "stomach 1: 21.2" "Cell type enriched" "Detected in some" 19 "granulocytes: 202.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 29 "basophil: 2.9" "Lineage enriched" "Detected in single" 29 "granulocytes: 2.9" "Group enriched" "Detected in some" 49 "HEL: 28.2;HMC-1: 40.4" "CAB002215, CAB032871, HPA040182, HPA049554" Supported "Intracellular and membrane" NA NA "Cluster 10: Basophils - Unknown function" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 60: Granulocytes - Receptor signaling" "CAB002215: AB_563870, CAB032871: AB_2206475, HPA040182: AB_2676875, HPA049554: AB_2680815" "unprognostic (5.99e-2)" "unprognostic (3.00e-1)" "unprognostic (1.38e-1)" "unprognostic (1.04e-2)" "unprognostic (8.97e-3)" "unprognostic (1.15e-4)" "unprognostic (1.70e-1)" "unprognostic (5.45e-2)" "unprognostic (9.00e-2)" "unprognostic (2.88e-1)" "unprognostic (4.30e-1)" "unprognostic (2.94e-2)" "unprognostic (2.50e-3)" "unprognostic (3.74e-2)" "unprognostic (4.14e-1)" "unprognostic (3.89e-1)" "unprognostic (7.46e-3)" 8.0 0.5 1.2 1.9 1.3 1.6 4.5 1.3 2.7 5.1 1.0 7.8 3.8 8.5 1.9 8.1 3.2 13.8 1.1 1.4 1.1 1.2 0.7 17.8 5.4 1.4 1.3 0.3 1.5 0.1 0.4 0.1 1.5 5.5 0.8 0.1 4.8 1.2 1.4 9.5 13.4 5.4 1.1 0.4 21.2 1.3 1.4 1.2 0.3 1.0 2.3 13.3 5.0 1.2 0.0 0.1 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 28.2 0.0 0.0 0.0 0.2 40.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.6 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 1.3 1.3 2.7 1.4 1.1 1.4 1.3 1.5 1.1 1.4 1.2 0.0 3.2 7.7 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 10.5 0.0 0.0 0.0 0.2 0.0 0.0 202.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.1 TPSG1 "PRSS31, TMT" ENSG00000116176 "Tryptase gamma 1" Q9NRR2 16 1221651-1225257 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "intestine: 14.7" "Cell type enriched" "Detected in some" 6 "Intestinal goblet cells: 278.9" "Cancer enhanced" "Detected in many" "colorectal cancer: 5.2" "Region enhanced" "Detected in single" "basal ganglia: 1.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 9 "HMC-1: 23.2;MCF7: 7.9" "Not detected" "Not detected" HPA060458 Enhanced NA NA "Cluster 9: Intestine - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 27: Mucus-secreting cells - Mucin production" "HPA060458: AB_2684283" "unprognostic (1.86e-1)" "unprognostic (3.46e-1)" "unprognostic (5.21e-3)" "unprognostic (1.27e-1)" "unprognostic (5.58e-2)" "unprognostic (1.18e-2)" "unprognostic (3.45e-2)" "unprognostic (4.60e-2)" "unprognostic (9.97e-2)" "unprognostic (1.34e-1)" "unprognostic (8.92e-2)" "unprognostic (6.39e-2)" "prognostic unfavorable (1.76e-8)" "unprognostic (2.19e-1)" "unprognostic (1.70e-1)" "unprognostic (8.65e-4)" "unprognostic (5.70e-2)" 0.7 1.0 0.4 1.4 1.6 0.0 3.2 0.0 0.4 0.7 0.0 14.7 14.1 1.3 0.1 0.8 0.7 1.0 0.3 0.2 0.4 1.2 0.4 0.8 0.0 0.1 0.1 2.1 0.2 0.0 3.1 0.0 0.3 1.1 9.0 0.1 0.3 0.2 0.2 1.2 9.3 0.3 0.1 0.0 1.1 1.6 0.5 0.0 0.1 0.0 0.0 1.8 0.8 0.0 0.0 1.3 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.0 0.0 0.9 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 1.3 0.0 0.0 0.0 0.0 23.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.9 0.0 0.0 0.7 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 1.6 0.0 0.4 0.2 0.4 0.1 0.1 0.3 0.1 0.5 0.0 0.0 0.0 0.6 0.0 0.2 0.1 0.0 0.0 0.0 0.0 1.2 0.6 0.7 0.0 0.0 0.0 0.0 0.0 0.0 9.1 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 41.9 0.0 0.0 0.4 0.0 0.0 0.0 278.9 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.0 0.0 0.3 0.1 5.6 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.8 0.0 4.7 0.0 TRHDE "PAP-II, PGPEP2, TRH-DE" ENSG00000072657 "Thyrotropin releasing hormone degrading enzyme" Q9UKU6 12 72087266-72670758 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 7.6;pancreas: 10.3" "Group enriched" "Detected in some" 4 "Excitatory neurons: 216.9;Inhibitory neurons: 292.7" "Cancer enhanced" "Detected in some" "renal cancer: 1.9" "Group enriched" "Detected in many" 5 "basal ganglia: 4.9;cerebellum: 4.4;cerebral cortex: 2.5;hippocampal formation: 7.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ: 30.3;BJ hTERT+: 29.1;EFO-21: 15.3;HBF TERT88: 10.3;hTERT-RPE1: 10.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA 7300000 "Cluster 22: Non-specific - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (3.56e-2)" "unprognostic (4.06e-3)" "unprognostic (6.01e-2)" "unprognostic (1.44e-6)" "unprognostic (1.77e-1)" "unprognostic (6.37e-2)" "unprognostic (7.79e-2)" "unprognostic (6.96e-2)" "unprognostic (3.99e-2)" "unprognostic (1.48e-1)" "unprognostic (5.14e-4)" "unprognostic (2.40e-1)" "prognostic favorable (1.53e-7)" "unprognostic (2.55e-2)" "unprognostic (2.48e-1)" "unprognostic (8.91e-3)" "unprognostic (2.94e-2)" 3.6 0.9 0.1 0.3 4.9 0.4 0.8 4.4 2.5 3.7 0.0 1.1 2.4 1.2 0.6 0.2 1.1 0.8 0.8 7.6 0.0 5.1 0.5 1.4 0.1 0.0 0.9 3.2 10.3 0.0 0.1 0.1 0.0 1.3 0.5 0.8 0.8 2.8 0.2 0.2 2.1 0.4 0.0 2.5 0.3 0.7 0.0 0.1 0.0 0.4 0.3 1.2 2.3 0.0 3.6 0.0 0.6 0.0 1.6 0.0 9.5 30.3 29.1 2.9 1.9 0.0 0.0 0.0 15.3 4.3 3.0 0.4 5.4 0.0 10.3 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 2.4 0.0 0.0 2.3 10.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 8.7 0.0 0.0 0.0 9.5 6.7 2.9 0.1 0.0 0.0 0.0 0.5 0.0 5.7 0.0 0.0 3.2 0.0 0.5 0.0 0.0 0.0 0.0 0.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 4.9 4.4 2.5 7.6 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.2 0.0 0.5 2.9 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.9 1.5 0.0 1.8 0.0 0.1 0.0 7.1 3.9 0.0 35.9 0.1 0.4 0.2 0.0 0.0 216.9 2.6 0.4 4.7 0.0 0.3 0.0 0.1 0.4 1.4 0.2 0.0 292.7 3.5 0.0 0.0 0.0 62.8 29.5 0.7 0.0 2.8 0.0 0.4 0.0 38.2 4.0 2.2 3.9 13.5 0.0 0.2 15.8 9.1 0.7 0.6 0.0 37.4 0.6 0.2 0.7 0.0 0.0 0.1 0.1 0.2 1.6 0.1 TYSND1 "MGC34695, NET41" ENSG00000156521 "Trypsin like peroxisomal matrix peptidase 1" Q2T9J0 10 70137981-70146700 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in many" 4 "Early spermatids: 120.7;Late spermatids: 227.4;Spermatocytes: 124.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HaCaT: 27.5;PC-3: 41.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030304 Approved Uncertain Nucleoplasm,Centrosome,Cytosol NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 66: Spermatocytes - Spermatogenesis" "Nucleoplasm, Centrosome" Cytosol "HPA030304: AB_10670560" "unprognostic (4.75e-3)" "unprognostic (4.30e-2)" "unprognostic (2.44e-2)" "unprognostic (7.69e-2)" "unprognostic (1.84e-1)" "unprognostic (4.53e-2)" "unprognostic (2.02e-2)" "unprognostic (1.55e-1)" "unprognostic (1.33e-1)" "unprognostic (1.10e-1)" "unprognostic (1.59e-2)" "unprognostic (2.80e-1)" "unprognostic (1.37e-1)" "unprognostic (9.26e-3)" "unprognostic (1.91e-1)" "unprognostic (1.30e-1)" "unprognostic (1.69e-2)" 5.7 6.0 1.4 1.9 1.3 0.9 5.4 1.7 1.8 5.8 1.1 4.9 3.3 4.1 0.6 11.8 4.5 0.6 2.9 1.0 0.9 5.2 6.4 2.8 1.8 2.1 0.7 4.2 6.2 1.3 3.4 1.3 0.8 5.7 0.6 0.2 5.7 1.5 3.2 11.4 5.0 0.3 0.6 5.4 3.9 14.2 0.9 1.2 4.6 0.5 0.9 4.8 6.5 1.4 16.0 10.2 0.8 6.2 1.0 0.9 3.7 2.2 1.4 2.0 1.8 6.2 9.6 13.8 6.0 0.5 0.6 27.5 1.0 3.9 0.4 8.9 9.5 0.7 2.9 3.3 2.4 1.2 0.1 2.0 7.6 1.7 3.1 1.2 1.4 4.9 0.1 4.3 0.8 6.3 5.3 5.6 3.3 3.5 41.7 8.9 2.6 6.2 0.9 2.6 7.4 3.8 6.7 14.8 6.1 0.2 9.4 1.1 2.6 2.5 1.7 4.8 8.7 14.9 9.9 7.0 2.9 6.2 1.8 0.0 0.8 0.7 3.8 1.2 2.4 3.0 2.2 2.8 0.9 3.3 3.0 2.6 0.3 2.0 0.7 0.7 2.6 1.4 1.4 1.3 1.7 1.8 1.0 0.9 2.1 0.7 0.8 0.6 0.9 1.4 6.1 9.6 5.3 4.9 12.6 14.3 14.5 13.3 14.8 6.9 14.8 16.9 4.2 27.1 7.8 11.0 0.0 35.2 15.5 14.6 17.6 7.8 120.7 5.5 6.8 6.3 14.3 5.0 6.7 9.5 9.8 7.5 5.1 6.3 13.4 9.3 6.8 16.5 12.1 0.0 6.0 12.1 16.2 10.7 6.6 227.4 9.3 8.2 12.4 6.5 6.1 7.0 12.3 11.6 5.5 5.5 11.6 7.9 7.5 14.5 19.2 16.5 3.9 4.4 6.6 6.9 6.1 124.7 12.5 22.4 18.5 16.7 14.0 10.6 21.0 8.8 UCHL1 "PARK5, PGP9.5, Uch-L1" ENSG00000154277 "Ubiquitin C-terminal hydrolase L1" P09936 4 41256413-41268455 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 692.7;pituitary gland: 285.4" "Cell type enhanced" "Detected in many" "Collecting duct cells: 115.8;Distal tubular cells: 258.2;Excitatory neurons: 147.1;Horizontal cells: 146.4;Inhibitory neurons: 118.4;Spermatogonia: 88.4" "Cancer enhanced" "Detected in all" "glioma: 129.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "EFO-21: 1142.2;SCLC-21H: 1160.6;U-251 MG: 1162.6;U-266/84: 1138.4;U-87 MG: 1209.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002580, HPA005993, CAB079024" Enhanced Supported Supported Nucleoplasm,Cytosol NA NA 500000 "Cluster 43: B-cells - Humoral immune response" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 39: Non-specific - Basic cellular processes" Cytosol Nucleoplasm "CAB002580: AB_563981, CAB079024: , HPA005993: AB_1858560" "unprognostic (1.54e-1)" "unprognostic (1.96e-1)" "unprognostic (1.12e-1)" "prognostic unfavorable (4.08e-5)" "unprognostic (2.34e-1)" "unprognostic (1.98e-1)" "unprognostic (6.28e-3)" "unprognostic (1.09e-2)" "unprognostic (4.31e-2)" "unprognostic (8.77e-3)" "unprognostic (3.56e-3)" "unprognostic (3.70e-2)" "unprognostic (1.82e-3)" "unprognostic (1.24e-2)" "unprognostic (7.12e-3)" "unprognostic (2.10e-2)" "prognostic unfavorable (1.93e-4)" 30.1 104.4 211.4 19.2 188.8 0.6 13.6 83.4 342.7 18.9 0.0 49.0 9.0 13.2 3.3 3.3 9.7 12.3 26.9 229.7 692.7 62.7 1.6 8.2 12.9 255.7 205.2 35.6 11.6 0.6 285.4 2.5 446.7 12.3 6.9 38.3 3.7 5.8 27.5 4.7 18.9 9.2 122.2 2.7 14.5 16.5 150.3 4.1 9.8 7.7 7.3 31.7 29.1 231.2 3.3 712.8 146.8 0.4 18.9 19.7 0.4 681.4 352.8 236.0 243.4 149.0 0.9 0.0 1142.2 384.4 356.7 1.1 262.8 0.6 116.4 1.5 97.0 0.0 6.9 0.2 529.3 0.1 1.2 127.4 3.0 197.9 0.0 413.7 2.0 0.0 0.0 2.3 122.6 0.6 1.0 12.3 435.3 0.0 714.1 0.1 297.2 0.7 386.3 0.3 1160.6 765.7 5.1 2.8 1.8 165.4 0.8 5.0 3.3 16.8 5.2 0.4 1162.6 583.1 1138.4 3.1 1209.3 1.1 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 211.4 188.8 83.4 342.7 229.7 692.7 255.7 205.2 446.7 122.2 150.3 231.2 0.8 0.0 3.1 29.0 2.1 1.7 1.1 1.5 1.2 25.6 0.3 0.6 3.1 0.0 3.5 115.8 8.4 3.6 0.0 0.1 258.2 4.3 3.5 0.9 9.8 3.9 4.2 0.8 147.1 0.8 0.8 35.4 1.1 0.5 2.5 46.3 8.9 0.6 4.7 146.4 118.4 0.0 4.1 0.6 3.4 6.0 37.0 2.3 3.6 35.6 0.6 21.6 0.0 55.8 54.6 3.0 0.0 17.3 9.2 3.7 0.0 17.1 7.4 61.3 0.0 3.6 35.7 10.4 88.4 0.3 1.6 1.5 1.3 20.0 0.2 1.0 UCHL3 ENSG00000118939 "Ubiquitin C-terminal hydrolase L3" P15374 13 75549480-75606020 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019678, CAB037139, CAB037208" Approved Supported Nucleoplasm,Cytosol No No 700000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Cytosol" "CAB037139: AB_1841234, CAB037208: AB_1841235, HPA019678: AB_1858583" "unprognostic (4.16e-1)" "unprognostic (3.84e-2)" "unprognostic (8.83e-3)" "unprognostic (1.14e-1)" "unprognostic (5.15e-2)" "unprognostic (6.46e-3)" "prognostic unfavorable (6.41e-4)" "unprognostic (1.19e-1)" "unprognostic (5.59e-2)" "unprognostic (9.71e-2)" "unprognostic (1.24e-1)" "unprognostic (7.09e-2)" "unprognostic (4.47e-2)" "unprognostic (3.97e-1)" "unprognostic (2.76e-2)" "unprognostic (8.84e-2)" "unprognostic (3.26e-2)" 20.7 56.9 20.6 20.2 24.2 33.5 34.2 20.3 25.2 15.3 17.2 35.4 21.6 12.4 63.2 58.0 13.0 17.7 29.3 21.7 20.5 32.2 50.9 15.0 21.3 18.6 18.9 7.4 30.9 23.9 22.9 24.6 18.5 19.5 39.5 9.7 27.2 18.2 53.9 48.6 19.9 25.1 18.9 15.9 25.1 43.3 20.5 25.7 44.4 40.6 34.6 44.3 26.6 21.0 196.0 31.9 26.9 18.8 49.9 58.6 78.6 72.3 70.3 90.7 100.5 177.5 92.1 100.4 50.2 75.7 70.2 105.8 64.1 175.3 137.1 53.8 55.9 62.2 50.7 114.9 71.6 150.4 45.7 52.6 118.7 71.7 114.2 38.4 90.1 79.6 70.0 27.9 138.9 70.2 62.4 100.2 40.3 229.0 95.1 49.5 42.9 66.3 108.4 77.9 81.0 23.8 40.8 78.3 34.5 58.2 45.7 42.0 70.8 39.6 47.9 42.7 98.2 39.5 45.5 117.1 80.4 161.3 29.0 57.6 68.7 49.3 29.9 134.4 39.6 51.5 54.1 43.0 99.5 51.5 53.0 49.5 15.6 62.7 117.9 134.9 71.8 50.1 20.6 24.2 20.3 25.2 21.7 20.5 18.6 18.9 18.5 18.9 20.5 21.0 18.2 9.6 23.4 9.1 20.3 76.3 80.4 197.5 35.9 9.3 48.8 66.2 27.2 28.6 88.2 46.0 2.1 105.2 32.9 39.0 92.0 146.2 198.2 35.4 17.4 26.6 24.0 24.4 22.5 143.1 163.6 25.1 23.9 36.2 24.1 19.3 13.9 45.7 88.0 16.8 22.3 54.6 81.4 28.8 28.8 43.5 16.8 32.8 26.6 18.7 33.3 17.3 22.6 22.6 24.9 153.1 44.3 11.7 33.3 133.1 40.4 119.6 48.0 8.9 19.7 24.5 73.5 159.3 36.8 64.8 79.1 169.0 22.1 47.6 60.8 96.2 UCHL5 "CGI-70, INO80R, UCH37" ENSG00000116750 "Ubiquitin C-terminal hydrolase L5" Q9Y5K5 1 193012250-193060080 "Enzymes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005908, HPA006069" Approved Supported Nucleoplasm,Nucleoli,Cytosol NA NA 18000 "Cluster 44: Non-specific - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 1: K-562 - Erythropoiesis" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Cytosol" Nucleoli "HPA005908: AB_1858585, HPA006069: " "unprognostic (3.66e-2)" "unprognostic (3.84e-3)" "unprognostic (5.17e-2)" "unprognostic (5.98e-2)" "unprognostic (1.20e-2)" "unprognostic (1.20e-1)" "unprognostic (3.50e-2)" "unprognostic (7.41e-2)" "unprognostic (1.96e-2)" "unprognostic (1.04e-3)" "unprognostic (3.44e-3)" "unprognostic (6.92e-2)" "unprognostic (6.41e-3)" "unprognostic (1.51e-1)" "unprognostic (7.15e-2)" "prognostic unfavorable (7.10e-5)" "unprognostic (4.33e-2)" 19.9 19.0 11.0 22.5 12.1 24.6 22.7 20.3 15.8 13.6 5.5 23.3 24.7 14.8 17.5 32.2 11.3 15.5 30.5 13.3 12.3 27.2 37.9 15.9 29.1 11.8 11.5 16.4 33.1 20.3 9.7 23.1 12.8 21.4 24.0 37.7 26.0 16.0 39.7 21.3 24.2 18.1 12.9 18.0 17.8 13.4 10.7 24.8 19.2 36.8 32.6 19.1 14.3 14.1 136.6 74.0 61.7 65.5 37.1 37.8 76.4 80.1 40.4 74.8 65.8 71.4 94.9 104.7 72.5 44.4 43.2 85.5 84.1 99.5 100.9 110.0 61.9 126.0 97.5 97.3 57.6 198.5 67.8 33.9 44.5 106.1 91.2 33.6 76.4 100.3 285.1 86.2 67.3 105.9 146.2 70.1 57.7 89.1 46.9 84.5 68.3 216.4 70.8 81.0 61.2 76.7 72.7 97.3 110.4 64.9 82.2 95.8 49.9 71.9 21.4 70.0 125.0 62.8 105.2 117.5 40.2 119.5 123.6 60.9 31.7 41.6 53.3 40.1 59.5 43.8 48.0 51.2 39.0 37.4 51.0 57.1 19.5 75.2 45.0 41.3 51.3 44.8 11.0 12.1 20.3 15.8 13.3 12.3 11.8 11.5 12.8 12.9 10.7 14.1 33.9 9.6 30.2 12.7 28.6 24.3 13.5 27.9 18.8 20.6 19.4 16.6 79.5 21.5 28.5 27.6 43.8 35.8 45.7 18.9 45.0 26.3 2.8 13.0 15.4 21.4 10.8 39.7 35.4 28.3 34.5 22.8 20.9 16.0 56.3 21.4 17.9 24.6 28.0 25.2 33.2 20.2 16.2 18.8 20.7 3.8 14.9 25.0 17.8 19.7 23.4 27.4 75.2 18.1 29.6 25.3 10.6 17.3 58.5 21.8 30.2 39.9 21.1 43.5 19.7 19.6 34.9 22.1 16.8 32.7 30.0 25.2 34.5 31.9 23.2 12.4 UFSP1 UFSP ENSG00000176125 "UFM1 specific peptidase 1 (inactive)" Q6NVU6 7 100888721-100889715 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal tubular cells: 7.9;Proximal tubular cells: 7.4;Sertoli cells: 6.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027099 Uncertain NA NA "Cluster 24: B-cells - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA027099: AB_2214069" "unprognostic (8.56e-2)" "unprognostic (2.62e-2)" "unprognostic (2.23e-1)" "unprognostic (1.94e-1)" "unprognostic (7.21e-3)" "unprognostic (1.18e-1)" "unprognostic (2.62e-1)" "unprognostic (1.51e-2)" "unprognostic (2.14e-1)" "unprognostic (2.11e-1)" "unprognostic (3.55e-3)" "unprognostic (5.71e-2)" "unprognostic (4.40e-2)" "unprognostic (1.77e-1)" "unprognostic (2.48e-1)" "unprognostic (2.46e-1)" "unprognostic (3.09e-2)" 2.0 2.7 1.2 0.9 1.3 0.6 1.6 1.9 1.7 1.5 0.2 1.8 1.0 2.4 1.3 1.9 1.8 0.1 1.6 0.9 1.2 2.1 3.1 1.0 0.6 1.4 1.5 0.9 3.1 1.0 2.3 0.4 1.4 1.8 0.5 0.3 1.7 1.0 3.7 1.1 1.5 0.8 1.2 1.6 1.9 0.7 1.1 0.8 1.4 1.2 0.4 2.1 1.1 1.5 2.9 3.7 0.8 3.8 3.6 2.1 2.3 2.2 0.7 0.9 0.6 1.5 2.0 0.7 1.7 1.8 1.4 5.6 1.1 1.3 0.5 2.6 8.2 2.4 3.2 1.8 3.6 1.0 1.1 2.4 1.6 1.2 4.6 1.0 0.3 1.4 3.7 1.7 1.4 7.3 2.4 6.0 2.8 3.0 5.1 1.2 1.1 5.8 1.6 1.3 2.6 4.3 4.4 5.6 2.7 1.1 1.4 0.9 0.9 2.4 2.5 2.6 1.7 1.7 2.2 0.2 0.8 2.0 2.8 0.0 2.4 1.5 3.1 2.1 3.5 1.0 2.6 1.7 2.9 3.9 2.9 3.6 0.4 3.0 2.2 4.4 1.2 1.7 1.2 1.3 1.9 1.7 0.9 1.2 1.4 1.5 1.4 1.2 1.1 1.5 0.7 0.0 0.0 0.0 0.8 0.6 2.3 1.3 1.8 0.4 1.4 1.3 0.8 1.5 0.7 1.8 0.0 2.4 0.8 2.5 7.9 2.2 0.3 2.2 3.6 0.8 3.0 0.8 0.3 2.1 1.2 1.2 1.1 1.2 0.0 0.6 1.8 4.7 1.9 0.0 0.3 2.2 0.0 0.8 0.7 0.4 1.8 0.6 0.0 1.0 0.5 2.5 0.0 1.0 0.2 1.8 5.0 1.9 1.3 3.2 1.6 7.4 0.7 1.0 6.6 1.5 1.5 0.2 0.3 2.4 1.0 1.6 0.8 4.4 2.5 2.2 UFSP2 "C4orf20, FLJ11200" ENSG00000109775 "UFM1 specific peptidase 2" Q9NUQ7 4 185399537-185425979 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 190.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039985, HPA043298" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 44: Non-specific - Transcription" "Cluster 54: Non-specific - Microtubule organization" "Cluster 30: Epithelial cell lines - Translation" "Cluster 66: Spermatocytes - Spermatogenesis" "Nucleoplasm, Cytosol" "HPA039985: AB_10794206, HPA043298: AB_10795037" "unprognostic (8.87e-2)" "unprognostic (1.85e-2)" "unprognostic (1.52e-1)" "unprognostic (1.97e-1)" "unprognostic (1.17e-1)" "unprognostic (1.29e-1)" "unprognostic (3.63e-2)" "unprognostic (3.19e-2)" "unprognostic (3.69e-1)" "unprognostic (1.50e-1)" "unprognostic (2.04e-2)" "unprognostic (2.56e-1)" "prognostic favorable (1.07e-8)" "unprognostic (1.92e-1)" "unprognostic (8.12e-2)" "unprognostic (9.36e-3)" "unprognostic (6.70e-3)" 21.2 24.9 19.9 9.5 21.7 5.7 24.3 25.2 24.1 21.6 29.6 19.5 13.0 19.9 28.1 25.8 17.7 15.6 32.1 20.4 21.9 37.3 24.1 17.1 11.9 20.4 20.2 31.4 19.7 23.8 10.0 14.0 20.9 19.8 15.3 56.4 20.3 19.2 48.5 21.6 12.0 20.2 20.7 14.5 17.5 21.0 21.3 14.3 25.9 40.6 16.1 16.2 10.1 25.3 17.5 11.9 28.8 24.3 25.8 25.6 15.3 20.3 20.5 19.3 19.3 18.4 23.2 17.9 9.0 19.7 14.7 16.1 20.4 32.2 17.4 21.8 12.4 11.8 13.0 23.3 30.2 15.3 12.3 14.7 26.8 16.5 16.7 26.7 35.7 21.9 24.8 34.3 28.2 16.3 22.0 16.4 8.7 11.8 16.7 20.2 11.5 20.4 31.9 11.4 18.6 14.8 11.3 25.6 23.1 17.6 15.4 13.6 27.3 9.5 16.8 7.5 17.2 34.6 14.8 9.5 30.5 11.0 25.3 10.8 12.3 7.6 21.2 10.4 25.7 22.0 21.7 24.1 14.1 15.4 23.2 22.9 0.7 21.5 11.1 19.9 20.6 12.5 19.9 21.7 25.2 24.1 20.4 21.9 20.4 20.2 20.9 20.7 21.3 25.3 33.8 6.4 23.9 14.7 30.1 22.0 28.7 35.1 33.0 47.6 20.9 25.5 27.0 15.7 31.1 20.2 66.7 26.0 23.4 8.3 111.6 28.3 190.5 16.4 28.9 24.1 19.3 24.0 12.2 33.1 29.7 34.2 20.4 19.2 29.7 21.9 21.8 17.3 27.2 18.5 17.8 18.6 28.5 22.1 18.8 52.9 35.4 18.5 35.6 12.2 17.3 71.8 21.6 23.6 33.2 19.7 14.6 42.2 53.0 15.4 22.2 100.9 23.7 87.9 65.7 31.8 38.9 89.3 56.7 22.6 18.9 41.9 27.1 35.6 14.8 19.6 UQCRC1 "D3S3191, QCR1, UQCR1" ENSG00000010256 "Ubiquinol-cytochrome c reductase core protein 1" P31930 3 48599002-48610976 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Electron transport, Respiratory chain, Transport" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 766.7;tongue: 882.7" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 662.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002815, HPA003525, CAB033782" Enhanced Supported Mitochondria NA NA 250000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 39: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "CAB033782: AB_2213631, HPA002815: AB_1080486, HPA003525: AB_1080484" "unprognostic (1.29e-1)" "unprognostic (3.15e-3)" "unprognostic (6.91e-3)" "unprognostic (1.06e-1)" "unprognostic (1.66e-1)" "unprognostic (9.91e-2)" "unprognostic (8.53e-2)" "unprognostic (1.99e-1)" "unprognostic (3.11e-2)" "unprognostic (9.14e-2)" "unprognostic (3.37e-1)" "unprognostic (7.20e-2)" "prognostic favorable (2.35e-10)" "unprognostic (5.37e-2)" "unprognostic (2.35e-1)" "unprognostic (1.02e-1)" "unprognostic (6.72e-2)" 66.0 58.2 93.7 46.9 97.1 62.4 55.0 117.3 110.1 50.7 127.2 156.9 156.3 35.5 50.4 78.9 66.2 33.9 387.7 96.7 115.0 131.3 149.0 42.1 42.8 111.0 101.7 36.1 87.4 192.2 30.6 56.0 114.6 51.8 129.6 52.9 105.9 77.5 766.7 78.6 125.4 62.8 99.3 41.0 103.3 52.1 111.6 72.7 48.4 882.7 58.0 63.5 40.0 101.4 118.2 169.6 136.7 145.0 147.5 117.0 225.2 129.4 206.1 196.5 178.9 272.8 107.1 193.4 94.4 143.2 274.1 123.6 171.6 280.9 91.7 138.3 173.8 214.7 186.7 317.1 186.9 164.4 152.2 150.9 293.6 183.2 274.6 167.5 172.5 173.7 110.5 107.1 152.5 192.0 156.7 241.6 157.6 229.6 324.2 103.4 138.1 273.5 235.8 178.7 84.4 107.5 182.8 218.7 211.8 92.0 163.1 178.0 112.5 107.7 153.7 179.5 272.4 124.8 121.4 136.5 192.7 233.9 319.0 251.3 643.7 325.4 204.7 665.7 193.7 260.0 203.5 206.1 593.3 227.7 177.1 175.2 158.2 194.4 608.0 235.0 258.1 988.2 93.7 97.1 117.3 110.1 96.7 115.0 111.0 101.7 114.6 99.3 111.6 101.4 31.5 57.7 50.4 17.3 59.0 117.6 164.6 339.4 103.6 41.9 59.3 46.1 662.2 140.2 139.2 121.4 29.2 334.4 28.0 550.2 365.9 163.7 155.0 64.0 41.6 53.4 144.5 80.6 16.9 166.3 311.1 78.2 167.7 61.5 82.4 72.5 49.6 188.0 238.2 40.4 22.0 319.6 223.8 118.1 85.4 331.9 58.4 107.7 119.2 12.2 129.1 67.1 51.5 14.6 12.5 163.5 333.3 70.7 117.6 78.4 553.4 398.4 104.7 65.0 59.2 61.2 153.0 110.3 74.7 173.0 105.4 336.7 50.8 172.1 416.8 153.4 UQCRC2 "QCR2, UQCR2" ENSG00000140740 "Ubiquinol-cytochrome c reductase core protein 2" P22695 16 21953288-21983660 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Electron transport, Respiratory chain, Transport" "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 722.2;tongue: 933.2" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 556.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007998, HPA019146" Enhanced Enhanced Mitochondria NA NA 180000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 8: Non-specific - Mitochondria" "Cluster 3: HMC-1 - Innate immune response" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "HPA007998: AB_1858648, HPA019146: AB_1858649" "unprognostic (1.33e-1)" "unprognostic (1.32e-1)" "unprognostic (1.49e-3)" "unprognostic (3.35e-1)" "unprognostic (1.26e-2)" "unprognostic (6.91e-2)" "unprognostic (2.71e-2)" "unprognostic (1.32e-1)" "unprognostic (1.72e-1)" "unprognostic (8.87e-2)" "unprognostic (1.67e-2)" "unprognostic (2.43e-2)" "prognostic favorable (6.58e-9)" "unprognostic (2.33e-1)" "unprognostic (9.78e-3)" "unprognostic (4.67e-3)" "unprognostic (7.36e-2)" 158.8 117.7 69.0 103.1 71.2 127.7 108.4 75.5 90.0 90.8 113.9 259.8 292.5 98.2 72.7 157.4 109.7 99.5 559.4 72.4 73.7 240.0 245.1 75.4 120.0 74.1 69.5 114.5 89.7 257.2 39.8 96.5 72.7 95.6 262.8 142.3 133.8 104.3 722.2 85.4 233.6 121.2 65.8 80.9 153.2 55.8 76.5 131.3 107.9 933.2 149.3 153.6 59.8 73.3 173.9 193.1 116.5 66.4 154.3 186.8 169.1 163.8 160.6 177.5 174.5 347.9 177.7 338.9 144.3 170.4 129.8 324.6 222.3 212.7 193.7 151.4 178.4 185.9 166.1 494.3 164.6 249.1 501.2 232.3 229.4 130.3 186.2 169.4 248.1 224.1 217.9 159.1 177.2 230.6 288.6 175.0 124.6 261.1 148.8 310.9 263.6 390.0 285.8 214.6 154.4 114.9 237.2 318.6 190.3 151.6 354.4 264.1 179.3 103.3 98.1 104.0 148.0 126.3 87.2 302.7 188.7 239.8 126.4 80.1 128.7 71.4 80.0 147.8 103.3 96.0 98.3 89.3 153.9 77.9 106.8 97.6 45.9 101.8 148.1 67.6 134.8 157.3 69.0 71.2 75.5 90.0 72.4 73.7 74.1 69.5 72.7 65.8 76.5 73.3 105.5 64.1 52.5 81.9 81.1 90.6 190.8 444.0 74.6 109.1 91.7 79.6 556.2 84.4 194.9 71.7 87.6 238.3 82.6 233.4 455.9 124.5 88.0 72.0 55.7 91.3 113.8 92.4 65.0 109.6 157.6 89.0 144.3 65.8 92.6 99.6 84.3 122.3 195.5 69.0 74.0 224.4 238.0 145.1 100.6 89.9 68.3 104.6 131.6 27.2 162.1 108.0 91.6 60.3 50.7 97.2 214.0 97.0 72.9 114.4 378.0 306.9 110.2 152.6 78.9 94.1 109.5 68.9 56.7 132.0 88.4 278.3 91.3 170.2 358.7 204.3 USP1 ENSG00000162607 "Ubiquitin specific peptidase 1" O94782 1 62436297-62451804 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 302.7;Spermatogonia: 206.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028387, HPA028440" Approved Supported Nucleoplasm NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "HPA028387: AB_2672578, HPA028440: AB_10603000" "unprognostic (1.22e-1)" "unprognostic (5.36e-2)" "unprognostic (1.78e-3)" "unprognostic (4.05e-3)" "unprognostic (2.57e-1)" "unprognostic (1.72e-2)" "prognostic unfavorable (5.81e-5)" "unprognostic (6.72e-2)" "unprognostic (1.11e-2)" "unprognostic (5.32e-2)" "unprognostic (3.33e-3)" "unprognostic (3.99e-2)" "unprognostic (2.76e-2)" "unprognostic (9.61e-3)" "unprognostic (5.70e-2)" "unprognostic (1.96e-1)" "unprognostic (1.71e-1)" 13.8 10.6 12.4 21.0 14.7 53.2 23.9 20.2 15.4 16.2 11.8 19.0 17.1 20.7 16.8 17.9 16.7 11.9 12.2 11.5 13.4 14.1 13.5 16.0 32.3 12.8 13.0 26.0 16.0 18.2 10.0 14.4 13.7 16.7 20.7 34.5 14.7 15.9 11.9 19.3 17.2 17.0 14.2 19.4 16.9 51.5 12.9 48.1 20.2 16.0 31.7 13.9 11.9 17.3 85.6 25.5 96.8 53.2 21.3 25.5 57.0 79.7 52.1 93.3 101.2 41.4 39.3 151.3 57.0 43.1 83.6 48.0 80.3 53.0 128.5 79.5 63.5 124.5 82.1 42.7 23.2 132.5 60.9 13.7 33.8 84.1 62.8 25.1 44.9 100.1 92.7 125.3 66.2 38.0 136.9 50.9 88.2 48.5 52.4 131.9 166.3 93.9 34.9 60.1 103.4 58.6 89.3 70.1 86.8 64.2 41.3 79.7 32.1 72.7 80.7 109.3 112.9 52.2 78.1 171.1 49.5 104.0 67.0 22.6 9.9 26.0 12.7 10.5 16.9 15.6 15.3 13.5 12.3 11.2 14.4 12.2 17.4 17.9 14.9 12.4 15.3 10.3 12.4 14.7 20.2 15.4 11.5 13.4 12.8 13.0 13.7 14.2 12.9 17.3 35.8 48.1 31.8 6.2 58.7 62.2 34.7 32.9 75.7 49.6 41.5 46.2 34.9 24.3 34.9 16.5 22.9 43.7 52.4 22.7 19.6 34.1 173.9 37.2 32.3 39.7 8.4 85.2 10.3 34.1 59.2 43.9 15.8 33.2 27.8 41.4 30.0 18.4 31.0 35.3 11.2 33.3 30.5 27.2 38.8 81.1 50.1 34.7 26.6 7.5 56.0 49.5 62.8 10.6 17.2 27.5 12.7 41.0 63.7 56.8 22.7 17.3 41.9 86.6 52.6 59.7 42.0 302.7 206.7 73.8 64.4 33.0 59.7 21.2 39.5 35.8 USP10 "KIAA0190, UBPO" ENSG00000103194 "Ubiquitin specific peptidase 10" Q14694 16 84699986-84779922 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Autophagy, DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 5 "neutrophil: 742.4" "Lineage enriched" "Detected in all" 5 "granulocytes: 742.4" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006731, HPA006749" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Cytosol Nucleoplasm "HPA006731: AB_1080495, HPA006749: AB_1080492" "unprognostic (4.14e-2)" "unprognostic (2.28e-1)" "unprognostic (2.36e-2)" "unprognostic (4.85e-2)" "unprognostic (6.93e-2)" "unprognostic (1.77e-3)" "unprognostic (1.03e-3)" "unprognostic (2.91e-3)" "unprognostic (1.75e-1)" "unprognostic (3.84e-2)" "unprognostic (2.56e-2)" "unprognostic (1.82e-3)" "prognostic favorable (1.00e-4)" "unprognostic (5.91e-2)" "unprognostic (4.57e-2)" "unprognostic (8.57e-2)" "unprognostic (1.38e-1)" 24.8 21.7 19.6 29.4 20.3 29.5 23.4 22.1 22.9 21.0 17.8 31.2 29.5 25.9 23.9 29.1 27.0 18.5 25.4 20.8 20.7 28.8 33.8 18.7 36.7 18.8 18.7 27.1 23.0 41.5 6.0 40.3 19.0 28.3 26.4 52.5 21.0 25.9 46.6 25.7 27.4 31.0 19.8 32.6 23.8 22.0 20.4 29.1 27.4 39.5 37.7 32.1 10.1 21.6 63.6 72.9 78.5 104.7 31.4 50.2 111.5 58.0 60.1 96.9 51.5 106.9 54.9 102.9 65.2 61.1 47.7 69.8 108.2 89.7 139.0 41.3 63.3 63.2 37.3 92.2 39.4 95.0 37.9 30.0 74.8 95.6 112.3 57.5 76.4 68.5 153.4 22.7 73.1 129.4 92.4 96.8 102.5 71.8 56.7 119.9 44.5 55.0 81.9 48.4 73.0 48.6 130.5 48.7 54.0 72.3 108.4 76.8 55.7 66.9 60.2 39.4 62.2 38.8 53.7 272.3 44.5 64.6 73.2 29.0 77.3 15.6 46.1 61.9 58.0 60.6 148.0 53.9 92.6 59.7 82.9 49.6 742.4 65.9 58.6 30.7 57.3 97.3 19.6 20.3 22.1 22.9 20.8 20.7 18.8 18.7 19.0 19.8 20.4 21.6 21.3 54.5 50.0 26.4 51.5 51.5 46.1 25.8 54.1 25.1 27.6 28.6 66.6 25.8 45.2 27.6 29.2 106.9 38.1 25.8 31.3 29.0 63.3 31.0 35.8 30.4 28.9 42.5 39.3 25.1 73.4 40.1 35.7 42.1 58.0 38.7 21.0 37.2 31.4 20.2 38.9 28.1 16.2 34.8 33.4 116.6 23.6 40.6 24.9 41.2 52.6 23.7 32.0 49.8 35.8 23.6 23.9 22.6 50.8 48.6 30.4 45.0 90.7 52.7 26.3 58.4 34.3 35.0 29.5 54.5 49.6 60.9 42.5 33.6 40.6 45.2 USP11 UHX1 ENSG00000102226 "Ubiquitin specific peptidase 11" P51784 X 47232866-47248328 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Bipolar cells: 203.6;Horizontal cells: 139.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003103, HPA037536" Enhanced Supported Supported Nucleoplasm,Cytosol "Intracellular and membrane" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 56: Bipolar cells - Visual perception" Nucleoplasm Cytosol "HPA003103: AB_10671088, HPA037536: AB_10672904" "unprognostic (1.60e-1)" "unprognostic (2.77e-3)" "unprognostic (5.84e-2)" "prognostic unfavorable (2.95e-4)" "unprognostic (3.08e-2)" "unprognostic (2.02e-1)" "unprognostic (6.11e-3)" "unprognostic (9.21e-2)" "unprognostic (3.18e-2)" "unprognostic (3.52e-1)" "unprognostic (3.29e-3)" "unprognostic (3.74e-2)" "prognostic favorable (4.13e-5)" "unprognostic (3.14e-2)" "unprognostic (9.23e-2)" "unprognostic (9.51e-2)" "unprognostic (7.11e-2)" 25.5 32.8 117.7 23.7 118.7 11.2 26.8 41.5 116.3 51.2 30.0 33.9 11.5 47.0 23.6 18.2 49.9 24.5 45.5 113.1 148.1 33.3 12.7 30.9 30.1 69.8 78.3 76.4 27.1 36.6 103.7 24.9 93.9 33.4 14.1 84.8 21.4 38.7 32.4 18.5 25.5 35.9 65.4 29.3 24.9 46.2 122.8 42.6 52.2 29.6 28.9 36.9 31.7 79.8 45.6 70.7 117.6 81.0 43.4 28.5 33.0 34.0 52.5 65.6 73.3 67.4 36.7 29.9 26.1 60.5 70.5 53.5 94.7 24.0 56.4 47.1 73.5 34.7 52.9 61.4 50.7 39.2 70.7 42.1 9.8 69.1 29.3 37.3 26.7 68.9 26.6 3.9 51.8 70.0 77.8 43.4 89.2 24.3 62.5 86.1 114.3 25.1 32.4 60.9 66.8 114.4 62.6 12.4 37.7 73.9 26.0 23.0 28.2 56.0 58.0 79.3 39.6 54.3 36.2 51.3 34.3 48.8 50.8 63.9 9.1 19.9 55.4 19.6 48.3 53.1 24.5 54.3 11.9 53.1 36.6 76.3 5.5 56.4 24.3 53.2 35.0 46.0 117.7 118.7 41.5 116.3 113.1 148.1 69.8 78.3 93.9 65.4 122.8 79.8 13.6 22.4 17.7 25.8 53.5 13.6 42.2 30.9 21.6 203.6 13.0 23.5 24.2 7.2 31.5 33.1 56.3 20.9 52.2 9.4 50.9 18.3 26.4 28.2 26.3 22.5 35.4 18.3 43.3 10.2 15.0 41.3 22.4 28.3 45.7 56.6 22.1 8.2 13.4 139.7 63.7 8.7 28.5 12.0 16.3 41.0 29.5 17.9 28.4 19.7 17.5 96.2 23.7 25.1 24.8 12.5 7.9 42.2 48.1 18.6 4.7 15.2 46.4 63.4 26.3 57.2 40.2 18.3 87.8 11.9 6.5 16.3 44.6 34.2 8.9 26.0 USP12 USP12L1 ENSG00000152484 "Ubiquitin specific peptidase 12" O75317 13 27066156-27171811 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Langerhans cells: 153.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007288, HPA059492" Uncertain Approved Nucleoplasm NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 41: Macrophages - Immune response" Nucleoplasm "HPA007288: AB_1080531, HPA059492: " "unprognostic (6.72e-3)" "unprognostic (2.63e-3)" "unprognostic (1.04e-1)" "unprognostic (2.34e-2)" "unprognostic (1.22e-1)" "unprognostic (5.85e-2)" "unprognostic (1.79e-1)" "unprognostic (3.39e-1)" "unprognostic (8.38e-2)" "unprognostic (8.77e-2)" "unprognostic (2.20e-1)" "unprognostic (3.06e-2)" "unprognostic (1.22e-2)" "unprognostic (1.40e-1)" "unprognostic (2.91e-1)" "unprognostic (6.77e-2)" "unprognostic (1.73e-1)" 20.4 13.6 21.0 20.9 22.0 75.7 15.3 21.6 26.7 13.1 15.5 35.6 18.2 13.2 15.1 17.0 13.5 17.9 14.4 23.7 22.2 24.8 34.9 23.6 29.4 18.9 24.8 14.7 15.3 16.5 13.8 17.7 19.5 14.0 25.5 38.0 10.2 12.1 13.1 24.0 24.3 18.6 21.0 17.2 17.7 15.5 22.2 12.2 16.1 15.9 26.4 21.8 13.5 21.8 24.9 15.3 28.6 14.9 18.8 23.8 10.2 34.1 23.9 18.5 13.7 27.7 37.8 35.1 16.6 27.0 44.9 15.0 18.9 19.8 39.4 57.0 16.1 54.3 19.2 19.6 23.6 31.8 36.5 14.9 28.3 21.0 23.9 23.4 43.3 23.8 18.4 16.5 38.9 14.4 19.6 42.0 20.5 31.5 26.7 22.1 36.5 8.3 36.3 17.3 31.5 19.0 29.3 24.2 28.2 35.5 11.4 30.4 51.6 19.3 18.6 41.6 31.4 12.6 15.0 24.6 32.4 18.5 22.0 0.0 0.5 2.2 0.5 0.5 0.9 1.2 0.9 0.8 0.6 1.6 0.6 0.6 0.5 0.9 0.8 1.1 1.4 0.4 21.0 22.0 21.6 26.7 23.7 22.2 18.9 24.8 19.5 21.0 22.2 21.8 54.2 28.9 29.9 19.6 42.1 91.6 29.4 7.0 34.7 23.8 30.6 24.0 23.4 17.2 9.1 23.9 39.6 15.4 26.5 47.0 29.4 12.8 19.2 29.1 26.4 42.0 20.9 60.6 37.0 16.3 7.0 34.2 23.9 68.9 13.3 15.7 21.4 23.3 14.0 28.6 29.0 27.5 10.2 20.8 153.8 10.7 7.8 47.8 39.2 42.2 33.6 13.8 9.2 43.7 65.0 24.4 37.4 6.4 37.1 34.0 34.3 21.3 12.2 32.1 32.9 114.7 42.8 2.7 12.9 23.1 79.0 10.9 27.2 9.3 24.1 40.6 USP13 IsoT-3 ENSG00000058056 "Ubiquitin specific peptidase 13" Q92995 3 179653032-179804366 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Autophagy, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 149.2;tongue: 108.9" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 208.5;Inhibitory neurons: 52.2;Theca cells: 58.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "MAIT T-cell: 15.6" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "HDLM-2: 93.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004827 Enhanced Approved Nucleoplasm,Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 54: Cardiomyocytes - Muscle contraction" "Nucleoplasm, Cytosol" "HPA004827: AB_1080497" "unprognostic (1.00e-2)" "unprognostic (2.09e-1)" "unprognostic (5.82e-2)" "unprognostic (7.14e-2)" "unprognostic (9.94e-2)" "unprognostic (3.96e-2)" "prognostic unfavorable (2.40e-5)" "unprognostic (1.76e-1)" "unprognostic (4.55e-2)" "unprognostic (7.79e-2)" "unprognostic (1.69e-3)" "unprognostic (2.22e-2)" "prognostic unfavorable (3.46e-6)" "unprognostic (4.93e-2)" "unprognostic (9.79e-2)" "unprognostic (3.38e-2)" "prognostic unfavorable (3.06e-4)" 6.2 11.9 3.9 2.8 13.6 1.5 5.3 8.6 12.0 3.3 0.0 2.9 1.2 5.7 3.4 4.0 3.4 4.5 42.5 3.7 4.7 3.0 4.6 5.4 3.6 11.3 10.5 12.5 4.1 4.0 5.8 2.6 12.7 4.3 2.2 7.1 6.2 2.7 149.2 2.2 1.9 6.3 6.4 2.1 1.7 6.0 8.1 2.4 9.7 108.9 3.5 3.5 2.2 34.4 27.6 11.3 20.0 14.8 8.9 14.1 11.6 18.6 17.4 23.7 18.8 17.1 9.6 35.6 18.0 17.2 27.6 2.6 21.4 9.1 26.4 93.3 14.8 9.0 23.6 14.4 6.3 26.5 1.1 10.5 3.0 18.8 18.5 9.1 16.6 11.9 4.7 43.0 15.7 15.0 22.5 3.0 17.9 1.3 13.1 29.3 20.2 27.4 11.7 7.9 13.0 14.5 14.1 16.9 7.2 5.4 37.0 12.7 24.1 28.6 27.6 23.7 64.1 29.5 21.2 78.3 13.0 15.0 27.2 0.1 0.3 0.0 2.6 0.5 15.6 3.2 1.8 3.8 1.5 0.9 1.2 1.3 0.0 0.0 0.7 4.5 0.7 1.3 3.9 13.6 8.6 12.0 3.7 4.7 11.3 10.5 12.7 6.4 8.1 34.4 45.0 9.6 35.9 14.0 5.3 2.5 1.9 1.4 0.6 13.7 7.1 5.2 208.5 5.7 5.4 1.8 6.2 10.7 5.6 1.4 15.6 1.1 2.6 13.9 11.4 10.1 9.6 5.5 23.2 4.4 2.4 12.0 4.1 2.5 2.5 35.5 22.1 7.6 4.3 16.8 52.2 2.9 0.0 4.8 3.5 3.6 9.3 5.0 14.2 16.9 1.7 7.0 3.1 36.2 42.5 1.0 12.2 9.4 4.5 4.4 0.1 2.7 3.7 10.2 13.1 17.8 12.0 6.1 2.8 4.8 1.6 5.1 4.1 58.8 4.5 1.4 USP14 TGT ENSG00000101557 "Ubiquitin specific peptidase 14" P54578 18 158383-214629 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Immunity, Innate immunity, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001308 Approved Supported "Plasma membrane,Cytosol" NA NA 2700000 "Cluster 15: NK-cells - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" "Plasma membrane, Cytosol" "HPA001308: AB_1080499" "unprognostic (2.21e-1)" "unprognostic (4.05e-2)" "unprognostic (1.90e-1)" "unprognostic (2.59e-3)" "unprognostic (6.04e-2)" "prognostic unfavorable (7.81e-5)" "prognostic unfavorable (4.30e-5)" "unprognostic (5.14e-2)" "unprognostic (5.00e-2)" "prognostic favorable (7.91e-4)" "unprognostic (1.64e-2)" "unprognostic (2.39e-1)" "unprognostic (1.51e-3)" "unprognostic (2.58e-1)" "unprognostic (1.55e-1)" "unprognostic (2.20e-2)" "unprognostic (3.76e-2)" 26.0 21.5 19.9 22.7 21.3 23.9 17.0 20.1 22.9 15.5 13.9 17.8 13.9 17.0 23.8 24.0 14.6 14.6 24.8 21.0 24.5 23.4 25.3 15.1 21.6 25.4 21.7 13.3 13.0 21.2 14.3 26.5 25.7 29.7 19.3 15.5 15.2 19.6 55.6 15.4 12.4 24.7 20.3 13.8 15.1 17.9 26.0 21.8 20.4 36.4 31.3 22.6 15.3 23.3 91.6 75.4 62.7 64.5 60.7 60.0 109.6 115.5 64.9 118.9 110.5 98.9 48.7 133.1 86.6 99.1 114.4 50.9 125.1 91.7 134.9 38.7 59.0 72.5 46.0 78.1 60.5 184.1 70.8 48.4 69.1 122.3 69.5 55.0 93.5 65.9 106.2 99.3 119.1 76.2 105.2 52.4 59.4 56.0 83.5 87.8 78.6 98.0 88.7 79.9 71.8 60.1 120.7 59.2 52.5 68.0 58.2 51.5 103.9 138.7 104.3 128.8 170.6 62.3 125.7 130.9 80.0 77.3 88.4 10.7 18.1 13.8 27.9 25.8 33.6 21.1 27.5 29.5 25.6 16.4 26.7 26.2 1.5 39.3 20.5 18.7 28.6 19.4 19.9 21.3 20.1 22.9 21.0 24.5 25.4 21.7 25.7 20.3 26.0 23.3 40.0 22.4 40.4 27.7 52.7 58.6 53.3 42.0 51.8 58.0 33.4 23.5 44.9 31.5 48.3 44.1 31.3 92.3 58.1 22.5 45.0 60.6 70.9 44.9 56.3 43.1 22.1 102.0 58.8 54.0 71.8 49.0 43.8 80.8 34.8 47.1 28.2 45.4 50.9 116.1 54.4 22.5 46.8 31.5 53.4 21.6 31.7 45.5 35.6 33.7 48.8 39.4 46.4 35.2 74.8 75.8 16.9 45.9 72.7 71.4 15.2 56.0 40.2 50.3 0.0 49.6 51.4 34.1 68.1 57.9 52.4 135.6 55.0 58.9 33.5 51.8 USP15 "KIAA0529, UNPH4" ENSG00000135655 "Ubiquitin specific peptidase 15" Q9Y4E8 12 62260338-62417431 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 176.2" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 297.9" "Lineage enriched" "Detected in all" 5 "granulocytes: 297.9" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006237, HPA006428, HPA071014" Approved Supported "Nucleoplasm,Nuclear bodies,Cytosol" NA NA 300000 "Cluster 1: Neutrophils - Mixed function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 1: K-562 - Erythropoiesis" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Cytosol "Nucleoplasm, Nuclear bodies" "HPA006237: AB_1080502, HPA006428: AB_2667588, HPA071014: AB_2686333" "unprognostic (8.18e-2)" "unprognostic (3.22e-1)" "unprognostic (9.63e-2)" "unprognostic (2.09e-1)" "unprognostic (1.10e-1)" "unprognostic (2.75e-1)" "prognostic unfavorable (8.04e-4)" "unprognostic (6.59e-2)" "unprognostic (7.70e-3)" "unprognostic (2.19e-1)" "unprognostic (2.47e-1)" "unprognostic (4.51e-2)" "prognostic unfavorable (1.58e-5)" "unprognostic (9.28e-2)" "unprognostic (5.81e-3)" "unprognostic (1.11e-2)" "unprognostic (1.26e-1)" 29.0 21.6 4.5 29.4 4.8 176.2 22.9 12.3 6.7 17.6 10.2 18.0 13.8 14.6 9.2 19.7 17.8 13.7 19.8 5.2 5.5 14.9 27.2 31.5 33.3 6.0 5.4 26.7 19.7 14.9 13.9 18.4 5.7 14.3 16.7 45.8 19.7 8.3 35.5 29.9 24.6 12.6 4.6 44.3 18.8 30.2 5.5 26.5 17.1 14.8 24.9 18.1 19.4 8.0 18.3 16.5 14.2 17.7 25.7 25.1 27.0 29.0 21.2 22.3 16.1 19.6 21.6 15.5 16.6 17.8 10.1 18.5 18.4 23.1 27.6 18.5 15.0 25.2 15.1 14.1 18.8 35.6 61.8 15.0 19.2 27.2 20.7 20.7 26.1 16.3 80.8 36.0 20.0 23.5 26.4 19.3 25.4 16.5 24.0 17.2 19.1 32.3 17.9 22.8 17.9 8.9 30.9 21.6 17.3 17.4 34.7 18.8 37.2 21.2 22.2 32.0 18.2 16.4 24.0 21.9 25.7 26.7 23.5 163.4 60.0 64.3 13.5 31.1 14.9 28.5 19.6 14.0 23.7 20.5 23.5 13.8 297.9 14.7 26.8 26.6 58.8 26.1 4.5 4.8 12.3 6.7 5.2 5.5 6.0 5.4 5.7 4.6 5.5 8.0 57.1 38.5 36.4 68.6 130.3 58.8 40.8 26.2 40.5 54.9 32.3 28.1 74.9 21.5 48.9 23.9 110.5 31.7 142.5 50.2 11.7 36.4 172.2 26.3 46.5 45.4 42.0 248.3 124.8 41.5 43.3 52.5 57.6 38.9 88.6 53.5 21.0 45.3 46.2 42.1 104.2 33.2 12.2 101.3 97.6 172.0 61.8 120.6 53.4 135.9 195.8 25.6 90.6 100.0 108.8 55.1 47.6 29.3 94.3 36.0 30.9 25.9 31.9 151.5 39.5 66.1 60.5 83.7 43.3 49.3 77.0 65.8 130.0 27.0 29.5 60.8 USP16 Ubp-M ENSG00000156256 "Ubiquitin specific peptidase 16" Q9Y5T5 21 29024629-29054488 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 514.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021140 Supported Approved Nucleoplasm,Cytosol NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 23: Testis - Cell cycle regulation" "Cluster 2: Karpas-707 - Immune response" "Cluster 29: Early spermatids - Spermatogenesis" "Nucleoplasm, Cytosol" "HPA021140: AB_1858668" "unprognostic (6.06e-2)" "unprognostic (3.14e-1)" "unprognostic (1.10e-2)" "unprognostic (1.47e-1)" "unprognostic (5.92e-2)" "unprognostic (5.79e-3)" "unprognostic (1.92e-1)" "unprognostic (8.99e-2)" "unprognostic (5.78e-2)" "unprognostic (7.40e-2)" "unprognostic (8.73e-2)" "unprognostic (8.65e-2)" "unprognostic (6.68e-2)" "unprognostic (2.84e-1)" "unprognostic (1.55e-1)" "unprognostic (2.84e-2)" "unprognostic (1.54e-1)" 27.0 23.0 18.8 23.4 23.2 29.3 27.4 21.3 20.4 22.7 19.1 24.6 25.1 25.2 25.2 25.2 19.9 20.4 29.3 17.5 20.5 22.1 30.7 20.9 27.9 20.5 20.8 22.3 26.0 34.3 16.7 24.2 21.7 25.7 26.4 42.3 24.7 23.6 34.7 19.9 22.8 22.6 20.2 21.9 23.4 25.7 20.3 30.0 33.8 37.5 32.3 27.1 14.1 27.5 59.9 23.4 36.5 33.0 25.4 41.5 34.2 56.9 37.9 38.5 36.4 29.5 38.3 60.5 16.8 54.8 58.7 26.5 45.6 41.5 50.1 58.6 48.4 80.9 27.3 33.1 37.6 80.3 43.0 35.9 42.9 50.3 46.4 28.7 37.5 33.9 67.7 103.8 45.3 27.3 49.7 29.3 39.2 48.4 29.9 33.0 89.7 69.6 31.7 42.5 39.4 41.9 36.8 58.1 51.1 24.9 40.2 54.2 38.0 44.8 55.7 41.8 59.3 87.8 129.3 62.5 46.8 57.3 45.6 37.4 24.1 33.6 36.3 24.9 28.6 40.7 34.1 33.6 23.1 46.0 36.9 35.8 23.5 31.5 34.0 36.2 38.9 17.2 18.8 23.2 21.3 20.4 17.5 20.5 20.5 20.8 21.7 20.2 20.3 27.5 60.3 86.6 91.9 27.4 114.4 57.2 132.5 68.9 55.2 161.0 65.8 58.7 84.2 64.3 83.1 53.3 89.6 81.7 108.2 90.2 133.1 77.9 514.9 85.9 82.6 55.0 82.6 40.8 18.2 119.9 79.7 68.3 55.0 107.7 141.8 61.5 45.7 86.2 59.9 72.3 27.6 100.4 44.7 62.0 53.1 117.0 87.7 69.4 62.2 25.3 117.3 94.1 96.8 28.1 47.3 94.0 99.2 86.9 106.8 100.1 74.8 91.8 94.1 183.5 59.2 133.4 83.2 100.4 82.4 68.4 64.4 162.0 105.3 72.8 90.6 141.9 USP17L1 USP17L1P ENSG00000230549 "Ubiquitin specific peptidase 17 like family member 1" Q7RTZ2 8 7332387-7333979 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Evidence at transcript level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.3 0.2 0.2 0.7 0.2 0.3 0.1 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L10 ENSG00000231396 "Ubiquitin specific peptidase 17 like family member 10" C9JJH3 4 9210657-9212249 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L11 ENSG00000233136 "Ubiquitin specific peptidase 17 like family member 11" C9JVI0 4 9215405-9216997 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "Evidence at transcript level" "Tissue enriched" "Detected in single" 37 "brain: 3.6" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "Cluster 65: Brain - Ion transport" "HPA045642: AB_2679403" 0.0 0.0 3.2 0.0 1.7 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 3.4 0.0 0.0 0.0 0.0 2.4 1.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 1.7 0.0 2.4 1.4 3.4 2.4 1.0 3.6 0.2 2.3 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L12 ENSG00000227551 "Ubiquitin specific peptidase 17 like family member 12" C9JPN9 4 9220152-9221744 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L13 ENSG00000232399 "Ubiquitin specific peptidase 17 like family member 13" C9JLJ4 4 9224896-9226488 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L15 ENSG00000223569 "Ubiquitin specific peptidase 17 like family member 15" C9J2P7 4 9234385-9236046 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "Evidence at transcript level" "Tissue enriched" "Detected in single" 87 "brain: 12.3" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "Cluster 65: Brain - Ion transport" "HPA045642: AB_2679403" 0.0 0.0 7.1 0.0 3.5 0.0 0.0 0.0 7.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 6.8 3.8 0.0 0.0 0.0 0.0 10.4 0.9 0.0 0.0 0.0 0.0 0.0 12.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.9 0.0 0.0 0.0 12.2 0.0 0.0 0.0 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.1 3.5 0.0 7.6 6.8 3.8 10.4 0.9 12.3 0.9 12.2 4.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L17 ENSG00000249104 "Ubiquitin specific peptidase 17 like family member 17" D6RBQ6 4 9243879-9245471 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Evidence at transcript level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L18 ENSG00000250844 "Ubiquitin specific peptidase 17 like family member 18" D6R9N7 4 9248630-9250222 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Evidence at transcript level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L19 ENSG00000248920 "Ubiquitin specific peptidase 17 like family member 19" D6RCP7 4 9253378-9254970 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L2 DUB3 ENSG00000223443 "Ubiquitin specific peptidase 17 like family member 2" Q6R6M4 8 12137168-12139077 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" "unprognostic (2.01e-1)" 0.0 0.0 0.3 0.0 0.5 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.5 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.5 0.0 0.6 0.2 0.5 0.0 0.2 0.3 0.0 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L20 ENSG00000250745 "Ubiquitin specific peptidase 17 like family member 20" D6RJB6 4 9258124-9259716 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "Evidence at transcript level" "Tissue enriched" "Detected in single" 17 "brain: 1.7" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "Cluster 73: Brain - Neuropeptide signaling" "HPA045642: AB_2679403" 0.0 0.0 0.6 0.0 0.4 0.0 0.0 0.1 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 1.0 0.0 0.0 0.0 0.0 1.7 0.7 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.4 0.1 1.0 1.2 1.0 1.7 0.7 0.7 0.3 0.9 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L21 ENSG00000249811 "Ubiquitin specific peptidase 17 like family member 21" D6R901 4 9262872-9264464 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L22 ENSG00000248933 "Ubiquitin specific peptidase 17 like family member 22" D6RA61 4 9267619-9269211 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "Evidence at transcript level" "Tissue enriched" "Detected in single" 18 "brain: 1.8" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "Cluster 65: Brain - Ion transport" "HPA045642: AB_2679403" 0.0 0.0 1.4 0.0 0.7 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.6 0.0 0.0 0.0 0.0 1.3 0.1 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.7 0.0 1.2 0.8 0.6 1.3 0.1 1.8 0.1 1.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L23 ENSG00000250913 "Ubiquitin specific peptidase 17 like family member 23" D6RBM5 4 9272364-9272914 "Enzymes, Predicted intracellular proteins" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L24 ENSG00000232264 "Ubiquitin specific peptidase 17 like family member 24" Q0WX57 4 9325165-9326757 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L25 ENSG00000230430 "Ubiquitin specific peptidase 17 like family member 25" Q0WX57 4 9329911-9331503 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L26 ENSG00000229579 "Ubiquitin specific peptidase 17 like family member 26" Q0WX57 4 9334658-9336250 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L27 ENSG00000235780 "Ubiquitin specific peptidase 17 like family member 27" Q0WX57 4 9344148-9345740 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L28 ENSG00000231051 "Ubiquitin specific peptidase 17 like family member 28" Q0WX57 4 9348893-9350485 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L29 ENSG00000231637 "Ubiquitin specific peptidase 17 like family member 29" Q0WX57 4 9353638-9355230 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L3 "USP17B, USP17F" ENSG00000225327 "Ubiquitin specific peptidase 17 like family member 3" A6NCW0 8 7976393-7977985 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L30 ENSG00000228856 "Ubiquitin specific peptidase 17 like family member 30" Q0WX57 4 9363129-9364721 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.3 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L4 ENSG00000236125 "Ubiquitin specific peptidase 17 like family member 4" A6NCW7 8 7337115-7338707 "Enzymes, Predicted intracellular proteins" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L5 ENSG00000227140 "Ubiquitin specific peptidase 17 like family member 5" A8MUK1 4 9339403-9340995 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L7 ENSG00000226430 "Ubiquitin specific peptidase 17 like family member 7" P0C7H9 8 12132417-12134099 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" "unprognostic (5.31e-2)" 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L8 ENSG00000237038 "Ubiquitin specific peptidase 17 like family member 8" P0C7I0 8 7971661-7973253 "Enzymes, Predicted intracellular proteins" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain NA NA "HPA045642: AB_2679403" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP18 ENSG00000184979 "Ubiquitin specific peptidase 18" Q9UMW8 22 18150170-18177397 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal tubular cells: 46.9;Extravillous trophoblasts: 31.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+ SV40 Large T+: 181.8;BJ hTERT+ SV40 Large T+ RasG12V: 196.2" HPA044768 Uncertain Supported Vesicles,Cytosol NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 64: Macrophages - Immune response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 38: Extravillous trophoblasts - Unknown function" Cytosol Vesicles "HPA044768: AB_10963697" "unprognostic (2.06e-1)" "unprognostic (3.55e-2)" "unprognostic (1.57e-2)" "unprognostic (5.04e-3)" "unprognostic (1.40e-2)" "unprognostic (5.42e-2)" "unprognostic (3.29e-2)" "unprognostic (5.11e-3)" "unprognostic (1.81e-1)" "unprognostic (1.79e-3)" "unprognostic (9.77e-2)" "unprognostic (1.47e-1)" "unprognostic (4.29e-3)" "unprognostic (2.58e-1)" "unprognostic (2.77e-2)" "unprognostic (2.28e-2)" "unprognostic (8.38e-2)" 10.8 5.0 3.6 5.1 3.8 8.1 8.3 3.3 4.5 4.0 4.0 5.0 6.0 3.2 7.8 4.0 7.3 6.6 4.4 3.7 3.9 5.9 23.6 7.9 9.2 5.1 3.9 2.9 4.2 3.6 5.7 5.7 4.2 5.3 4.4 0.7 14.0 2.5 3.8 3.4 6.7 4.0 7.0 11.0 7.2 9.7 4.1 15.0 7.3 5.5 6.5 4.0 3.6 3.7 14.4 14.6 4.2 18.2 18.2 13.5 18.4 7.3 17.5 181.8 196.2 2.2 20.1 0.2 10.8 4.0 57.5 4.9 21.6 6.4 6.2 64.4 29.4 28.3 1.9 27.0 2.1 6.9 25.7 6.0 2.5 12.8 0.0 1.0 40.8 20.6 1.4 1.7 1.8 24.9 33.4 16.7 12.7 15.6 11.0 13.1 28.4 0.0 3.6 12.4 15.2 11.9 8.8 15.0 71.9 16.3 9.9 6.6 66.7 1.3 3.5 4.1 7.5 3.4 45.4 0.2 16.3 17.1 10.5 3.2 3.9 8.3 8.5 11.0 10.7 5.3 7.2 11.1 1.8 3.4 8.2 9.6 0.7 13.3 8.6 3.3 13.1 5.3 3.6 3.8 3.3 4.5 3.7 3.9 5.1 3.9 4.2 7.0 4.1 3.7 9.7 9.6 4.8 0.7 2.5 1.7 4.5 5.7 2.2 0.2 8.4 8.3 1.4 8.6 6.9 0.0 0.0 4.6 3.0 6.2 46.9 5.9 1.6 20.1 2.5 8.4 3.0 1.3 0.5 11.1 31.9 7.1 4.1 6.3 0.0 8.5 11.0 5.5 8.7 0.0 0.6 3.5 6.1 6.3 0.8 1.7 3.7 3.8 3.6 0.0 1.6 5.1 8.2 2.0 0.3 13.4 3.2 7.2 2.3 2.5 5.4 8.0 12.2 0.3 6.6 8.0 2.5 10.9 1.0 4.0 1.0 1.5 5.0 5.5 2.8 2.9 USP19 "KIAA0891, ZMYND9" ENSG00000172046 "Ubiquitin specific peptidase 19" O94966 3 49108046-49120938 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 16: U-266 - Nucleosome" "Cluster 10: Non-specific - Unknown function" "unprognostic (3.23e-2)" "unprognostic (2.12e-1)" "unprognostic (5.91e-2)" "unprognostic (1.37e-1)" "unprognostic (1.92e-2)" "unprognostic (3.90e-3)" "unprognostic (2.99e-2)" "unprognostic (3.00e-3)" "unprognostic (2.69e-1)" "unprognostic (3.65e-2)" "unprognostic (2.31e-2)" "unprognostic (1.26e-1)" "prognostic favorable (7.05e-9)" "unprognostic (2.99e-1)" "unprognostic (2.11e-1)" "unprognostic (1.72e-3)" "unprognostic (7.54e-2)" 20.3 25.5 16.4 19.4 18.7 26.8 19.6 19.0 18.6 21.9 24.4 26.2 22.4 24.3 19.1 19.7 24.3 15.5 26.8 17.4 16.8 18.9 18.6 17.7 21.5 19.0 17.5 22.8 21.2 31.0 17.5 16.5 17.9 19.4 15.9 14.3 29.6 24.4 75.6 26.5 21.9 18.9 16.7 22.9 21.6 20.8 18.4 27.4 23.6 45.0 16.8 23.3 19.6 19.5 20.2 26.3 28.6 42.1 36.8 24.1 38.7 23.1 26.1 35.1 28.7 28.7 27.3 41.6 22.2 24.4 36.2 24.1 40.3 29.1 16.0 32.7 32.1 42.5 56.4 22.8 36.1 45.7 40.5 33.8 22.7 36.9 24.1 25.9 24.2 33.8 30.8 28.4 18.9 23.9 42.6 43.0 58.2 27.4 44.1 19.4 24.3 45.7 22.3 37.4 16.5 51.4 33.3 38.1 34.9 26.1 26.0 55.4 21.8 24.5 30.5 36.7 33.7 77.7 97.1 38.0 32.8 34.3 32.6 9.7 3.7 5.3 4.5 3.6 4.2 2.8 3.7 5.2 4.6 2.9 3.3 3.9 7.5 2.9 4.4 1.9 2.7 4.3 16.4 18.7 19.0 18.6 17.4 16.8 19.0 17.5 17.9 16.7 18.4 19.5 7.8 12.8 14.5 10.4 7.2 6.2 3.8 8.5 8.6 12.7 8.7 7.4 13.1 5.7 9.9 7.3 18.8 9.6 9.2 17.1 5.9 7.7 3.6 14.8 8.7 7.6 9.1 10.3 8.4 7.8 5.3 7.7 14.3 9.5 2.5 8.1 7.9 13.6 9.0 13.5 8.0 11.6 10.2 8.7 4.7 4.9 13.1 6.8 3.6 2.8 6.5 8.7 3.1 8.0 7.7 11.5 13.9 12.4 7.4 4.2 16.3 7.7 14.9 11.4 13.1 12.3 11.1 16.2 13.2 9.1 5.4 13.5 8.0 9.8 13.4 3.1 USP2 UBP41 ENSG00000036672 "Ubiquitin specific peptidase 2" O75604 11 119355215-119381711 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Biological rhythms, Cell cycle, Myogenesis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 168.3" "Group enriched" "Detected in many" 5 "Early spermatids: 460.0;Late spermatids: 1094.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "K-562: 14.5;U-266/70: 56.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006777, HPA007222" Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 54: Non-specific - Microtubule organization" "Cluster 29: U-266 - Adaptive immune response" "Cluster 31: Spermatids - Spermatogenesis" Cytosol "Plasma membrane" "HPA006777: AB_1080507, HPA007222: AB_1080505" "unprognostic (6.83e-2)" "unprognostic (2.02e-2)" "unprognostic (5.54e-2)" "unprognostic (1.37e-2)" "unprognostic (1.25e-1)" "unprognostic (7.46e-3)" "unprognostic (1.00e-1)" "unprognostic (5.27e-2)" "unprognostic (1.24e-1)" "unprognostic (5.24e-3)" "unprognostic (8.02e-3)" "unprognostic (7.33e-2)" "prognostic favorable (3.09e-11)" "unprognostic (1.58e-1)" "unprognostic (1.20e-1)" "unprognostic (1.96e-2)" "unprognostic (2.66e-2)" 7.0 13.4 11.9 1.6 22.6 1.9 4.1 18.8 19.0 6.0 32.7 10.2 13.9 5.2 5.7 9.8 11.6 2.3 73.5 18.6 9.4 53.4 18.9 3.4 0.1 12.0 13.1 6.2 18.1 24.2 18.9 1.3 7.7 4.1 6.0 76.2 7.6 3.0 168.3 12.8 17.4 6.8 8.2 0.6 6.2 86.5 15.1 0.6 3.8 62.8 0.6 4.5 4.8 17.5 6.0 0.5 0.9 3.2 0.1 0.2 1.3 0.7 0.4 0.0 0.6 6.1 0.8 10.2 1.8 1.1 1.4 1.0 7.9 2.9 0.2 7.2 1.0 2.8 4.4 12.5 2.7 0.0 2.8 0.9 0.6 0.7 2.0 1.3 0.6 7.6 14.5 0.8 1.7 4.1 0.0 0.6 1.6 2.0 1.3 0.1 2.1 1.5 4.6 0.3 11.9 3.6 3.4 2.6 0.7 1.7 8.8 6.2 0.0 0.0 1.5 0.8 1.0 56.9 13.5 0.2 0.1 2.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.9 22.6 18.8 19.0 18.6 9.4 12.0 13.1 7.7 8.2 15.1 17.5 0.6 3.2 2.7 10.7 0.6 2.4 5.3 1.5 1.2 75.2 3.3 2.4 85.2 7.2 6.1 5.5 95.9 0.5 1.6 25.5 113.5 3.1 460.0 39.0 3.0 3.6 0.0 0.4 15.7 1.6 0.9 7.4 2.0 8.4 0.0 2.0 2.2 23.0 17.2 10.1 11.6 2.0 0.0 1.3 2.9 1094.1 6.5 2.1 0.0 1.9 0.0 49.7 0.0 8.0 12.5 1.2 11.8 7.2 0.1 1.1 41.3 41.6 35.0 140.0 19.7 43.3 24.0 50.5 16.5 12.9 4.0 1.4 1.3 0.5 2.6 2.9 USP20 KIAA1003 ENSG00000136878 "Ubiquitin specific peptidase 20" Q9Y2K6 9 129834698-129881828 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Endocytosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "JURKAT: 95.9;K-562: 60.2;MOLT-4: 56.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006287, HPA007008" Uncertain Supported Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 58: T-cells - T-cell receptor" "Nucleoplasm, Plasma membrane, Cytosol" "HPA006287: AB_1080510, HPA007008: " "unprognostic (2.64e-2)" "prognostic favorable (8.01e-4)" "prognostic unfavorable (2.48e-4)" "prognostic favorable (4.01e-4)" "unprognostic (4.69e-1)" "unprognostic (1.89e-2)" "unprognostic (2.25e-1)" "unprognostic (2.55e-3)" "unprognostic (1.24e-1)" "unprognostic (7.89e-2)" "prognostic favorable (1.54e-7)" "unprognostic (2.09e-1)" "prognostic favorable (5.65e-5)" "unprognostic (1.76e-2)" "unprognostic (1.20e-1)" "unprognostic (1.19e-2)" "unprognostic (1.24e-2)" 8.1 12.0 8.7 13.5 8.0 22.6 8.3 4.8 8.7 12.5 2.5 13.6 8.2 12.5 4.2 7.9 12.1 7.7 7.5 7.8 10.6 7.6 7.4 8.4 18.3 10.2 9.1 13.5 10.9 8.4 18.4 6.7 10.0 14.8 4.9 6.7 11.4 13.2 10.9 12.1 12.5 8.2 5.4 13.9 9.9 10.0 8.9 32.3 18.7 7.5 11.8 14.9 10.1 6.5 6.0 5.8 10.0 13.4 12.8 10.8 14.1 9.5 7.9 7.1 4.9 4.7 6.5 8.1 8.0 9.3 8.0 14.7 6.0 6.7 2.9 43.4 7.9 14.9 17.0 3.3 8.8 14.2 10.6 9.6 9.8 9.3 7.0 12.4 7.7 95.9 60.2 9.9 4.4 15.9 56.4 33.6 7.9 12.7 13.6 9.4 11.2 14.0 5.5 6.5 2.2 11.0 11.0 13.9 9.1 5.9 14.4 19.9 11.5 7.8 3.5 10.5 6.3 9.7 15.3 5.7 15.5 18.6 7.4 1.0 1.9 5.4 8.6 1.5 9.1 3.7 8.7 8.3 2.6 3.4 9.8 8.9 2.8 10.0 1.5 2.1 11.5 6.3 8.7 8.0 4.8 8.7 7.8 10.6 10.2 9.1 10.0 5.4 8.9 6.5 3.0 9.6 6.9 16.3 9.2 2.8 2.2 2.5 4.0 7.8 6.4 8.0 7.7 4.3 3.0 1.8 4.2 5.9 9.4 6.2 3.9 2.4 2.1 4.1 6.3 4.3 8.4 12.8 17.0 4.0 2.5 4.6 8.2 5.7 1.3 6.8 6.4 6.1 3.3 10.1 21.1 4.6 4.1 1.6 3.8 3.3 6.2 6.0 3.6 11.2 3.1 5.3 11.3 9.5 14.3 2.7 5.0 4.9 6.7 3.0 4.1 2.9 5.0 6.3 0.0 4.3 5.7 12.1 6.0 4.8 2.0 6.2 19.3 2.9 5.2 1.6 USP21 "USP16, USP23" ENSG00000143258 "Ubiquitin specific peptidase 21" Q9UK80 1 161159450-161165723 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 16.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA028397 Uncertain Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 80: Striated muscle - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 59: Non-specific - Transcription" Cytosol "Nucleoplasm, Plasma membrane" "HPA028397: AB_10603227" "unprognostic (9.17e-2)" "unprognostic (1.44e-1)" "unprognostic (3.95e-2)" "prognostic unfavorable (7.05e-4)" "unprognostic (1.22e-2)" "unprognostic (1.26e-2)" "prognostic unfavorable (1.68e-4)" "unprognostic (5.35e-2)" "unprognostic (6.73e-2)" "unprognostic (2.76e-2)" "unprognostic (3.87e-3)" "unprognostic (1.31e-2)" "prognostic unfavorable (9.50e-6)" "unprognostic (2.45e-1)" "unprognostic (3.28e-1)" "unprognostic (2.13e-2)" "prognostic favorable (3.35e-5)" 12.2 15.3 19.6 11.9 20.7 15.0 14.3 18.5 22.8 19.4 18.3 17.6 13.6 18.2 12.0 16.4 28.0 12.0 13.0 19.4 18.4 14.5 10.8 13.1 16.1 19.2 19.7 23.2 16.4 17.1 15.7 13.2 18.7 17.7 11.0 12.9 16.5 20.3 20.9 20.8 15.9 12.6 17.3 17.8 16.4 14.2 20.1 18.4 18.5 17.7 14.0 17.6 16.8 22.1 12.5 20.6 26.9 26.2 21.1 17.5 16.5 9.1 14.6 24.2 18.9 19.4 23.3 16.0 14.6 11.2 15.1 20.7 17.6 17.5 13.2 30.8 30.0 19.3 34.1 15.3 15.2 17.4 13.4 14.8 23.0 16.6 23.9 27.1 17.3 35.0 28.4 21.6 15.6 22.6 30.7 26.9 25.2 24.3 26.1 28.8 9.0 26.5 14.4 14.9 24.2 31.5 17.2 17.2 13.9 20.1 37.3 27.5 10.1 16.9 14.8 11.9 15.3 42.9 36.5 23.9 15.3 14.7 15.5 15.2 10.0 17.1 12.6 6.4 14.6 11.0 11.5 13.2 10.8 11.3 13.1 12.3 8.4 13.3 7.6 10.8 12.3 11.0 19.6 20.7 18.5 22.8 19.4 18.4 19.2 19.7 18.7 17.3 20.1 22.1 4.5 0.0 3.7 5.2 6.5 1.5 1.8 2.4 16.5 5.0 4.9 4.1 3.9 8.6 2.9 1.8 6.2 4.9 3.6 3.6 1.9 2.0 1.0 6.3 5.7 4.4 5.4 10.7 2.4 2.3 2.3 5.1 9.2 3.7 2.5 4.5 5.3 2.1 2.2 0.0 2.7 4.0 4.1 4.8 0.8 1.0 5.0 2.1 1.8 1.9 1.2 3.3 5.2 2.0 4.6 2.0 2.4 4.1 7.8 2.7 3.5 2.5 9.5 5.2 6.6 2.0 5.2 5.3 3.2 10.7 1.4 3.1 5.6 3.1 4.1 1.5 USP22 "KIAA1063, USP3L" ENSG00000124422 "Ubiquitin specific peptidase 22" Q9UPT9 17 20999596-21043760 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044980 Supported Approved "Nuclear speckles" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 52: Non-specific - Transcription" "Nuclear speckles" "HPA044980: AB_10794503" "unprognostic (7.24e-2)" "unprognostic (5.38e-2)" "unprognostic (7.67e-2)" "unprognostic (6.19e-2)" "unprognostic (4.72e-1)" "unprognostic (1.11e-2)" "prognostic unfavorable (9.66e-4)" "unprognostic (2.17e-2)" "unprognostic (7.81e-2)" "unprognostic (6.37e-2)" "unprognostic (1.07e-3)" "unprognostic (5.68e-2)" "prognostic favorable (1.53e-7)" "unprognostic (8.95e-2)" "unprognostic (1.93e-1)" "unprognostic (2.91e-1)" "unprognostic (1.79e-2)" 40.7 66.8 91.2 40.3 93.7 53.0 42.5 72.0 90.5 55.3 44.8 48.8 33.6 63.7 48.2 40.7 57.3 40.0 79.8 93.1 112.3 49.5 44.1 46.3 48.3 71.7 78.1 75.6 48.0 68.2 65.2 39.3 85.8 50.2 35.2 57.1 36.3 48.2 108.6 40.3 39.5 54.0 72.4 45.1 49.8 29.3 120.3 63.9 57.0 81.2 50.2 42.3 35.4 68.4 106.9 189.7 179.9 155.5 102.7 105.9 85.9 120.2 91.8 105.6 89.3 220.0 46.9 145.4 112.5 185.2 71.3 111.7 176.7 143.1 157.1 70.0 122.8 120.8 121.5 107.9 121.3 134.2 101.0 117.4 83.9 119.9 125.1 119.8 134.1 93.3 139.7 51.4 151.6 109.5 189.8 63.7 93.1 125.5 61.9 206.2 284.5 99.2 97.7 153.9 86.3 177.8 154.9 63.5 124.9 488.4 106.4 78.0 171.0 107.4 140.8 111.3 164.1 55.0 79.6 476.2 109.0 70.3 169.4 5.5 9.6 10.0 7.9 7.6 7.9 8.0 8.1 7.8 9.2 9.9 10.7 10.2 9.9 7.1 9.7 7.6 6.1 6.0 91.2 93.7 72.0 90.5 93.1 112.3 71.7 78.1 85.8 72.4 120.3 68.4 46.6 41.7 48.8 31.6 47.9 33.0 43.8 33.8 38.7 97.6 80.3 63.8 23.8 45.8 41.5 60.7 93.8 51.4 36.6 59.3 23.5 51.6 36.0 59.3 75.3 56.1 88.2 43.7 53.1 59.0 37.5 51.0 57.6 68.7 30.4 86.5 76.8 68.5 38.1 117.8 66.0 48.8 30.5 53.8 36.1 51.2 51.0 31.7 35.6 43.1 42.2 55.4 28.8 38.7 50.6 69.6 40.3 71.8 36.6 62.2 33.4 48.9 37.4 59.1 13.1 58.6 52.2 15.9 19.7 49.6 29.1 65.8 33.4 77.9 53.3 53.5 USP24 KIAA1057 ENSG00000162402 "Ubiquitin specific peptidase 24" Q9UPU5 1 55066359-55215364 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in many" 4 "Oligodendrocyte precursor cells: 552.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026723, HPA028428, HPA067124" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 1: K-562 - Erythropoiesis" "Cluster 68: Oligodendrocytes - Mixed function" Nucleoplasm Cytosol "HPA026723: AB_10599851, HPA028428: AB_10600991, HPA067124: AB_2685785" "unprognostic (2.28e-1)" "unprognostic (9.81e-3)" "unprognostic (4.70e-3)" "unprognostic (4.86e-3)" "unprognostic (9.31e-3)" "unprognostic (4.84e-3)" "prognostic unfavorable (1.34e-7)" "unprognostic (2.04e-1)" "unprognostic (6.93e-2)" "unprognostic (2.98e-1)" "unprognostic (5.08e-2)" "unprognostic (1.86e-1)" "unprognostic (8.12e-2)" "unprognostic (1.79e-1)" "unprognostic (6.42e-2)" "unprognostic (4.12e-2)" "unprognostic (1.64e-1)" 16.6 8.2 13.4 14.2 13.3 56.7 13.4 25.3 13.6 9.4 13.2 12.0 8.3 10.7 9.2 9.4 9.9 9.0 12.7 12.6 14.7 15.7 15.3 10.6 22.1 13.5 13.1 16.5 11.4 20.3 12.8 9.6 14.6 10.2 13.3 17.2 12.8 9.6 47.9 13.6 12.6 9.8 12.8 18.6 12.3 8.4 13.6 21.9 9.2 36.6 20.9 10.4 9.2 14.2 32.5 17.4 21.3 11.6 27.2 23.5 24.6 14.0 17.5 19.6 20.3 25.0 11.1 25.9 15.1 26.1 40.1 25.6 28.5 23.6 30.5 27.2 17.4 51.5 40.2 29.6 16.1 36.0 38.6 21.0 20.6 30.0 33.7 19.0 18.2 25.7 48.5 10.6 26.6 7.6 21.9 19.1 31.4 15.5 21.0 22.3 27.1 11.3 34.6 21.4 18.7 13.1 23.8 16.8 21.1 32.3 11.7 17.5 24.7 17.9 17.3 21.7 22.6 13.2 10.6 33.2 16.9 29.4 16.3 5.4 1.3 1.7 2.8 1.1 1.7 3.0 2.2 2.2 1.2 3.4 1.9 2.5 1.4 2.3 1.5 6.9 1.3 0.7 13.4 13.3 25.3 13.6 12.6 14.7 13.5 13.1 14.6 12.8 13.6 14.2 20.4 16.0 20.0 92.4 27.7 14.9 8.4 5.6 9.1 14.0 13.4 10.2 37.7 10.0 13.0 12.9 73.0 4.2 42.6 11.1 0.0 10.3 0.7 11.9 15.1 16.1 17.3 37.4 84.5 10.2 7.8 11.9 21.4 15.0 12.7 18.2 12.1 11.9 9.7 38.7 100.4 16.2 8.2 19.2 18.8 2.5 11.8 18.6 10.6 87.1 19.6 7.0 15.5 552.4 115.2 11.8 11.4 7.9 18.1 12.7 8.3 5.9 10.0 16.9 6.6 18.0 13.5 7.7 7.1 13.9 17.2 1.5 21.8 9.8 16.0 12.1 USP25 USP21 ENSG00000155313 "Ubiquitin specific peptidase 25" Q9UHP3 21 15730025-15880069 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 120.9" "Cell type enhanced" "Detected in all" "Early spermatids: 166.7;Excitatory neurons: 148.0;Late spermatids: 192.8;Oligodendrocyte precursor cells: 150.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018297, HPA024142" Approved Supported Cytosol NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 30: Epithelial cell lines - Translation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "HPA018297: AB_1858672, HPA024142: AB_1858673" "unprognostic (6.35e-2)" "unprognostic (1.50e-1)" "unprognostic (6.90e-2)" "unprognostic (6.29e-2)" "unprognostic (1.39e-1)" "unprognostic (2.88e-2)" "unprognostic (3.91e-2)" "unprognostic (1.65e-1)" "unprognostic (1.44e-2)" "unprognostic (1.38e-1)" "unprognostic (2.33e-2)" "unprognostic (1.40e-1)" "unprognostic (8.24e-3)" "unprognostic (2.34e-3)" "unprognostic (4.50e-2)" "unprognostic (1.61e-1)" "unprognostic (2.32e-2)" 25.8 12.9 13.4 16.8 20.1 26.9 17.6 12.6 17.2 18.1 12.3 15.3 12.6 26.8 18.7 21.4 16.8 12.4 28.1 16.2 4.2 21.4 20.2 24.0 20.1 4.7 4.3 14.1 15.9 14.3 7.6 29.4 4.8 17.9 16.1 9.5 17.5 24.6 120.9 13.1 13.3 36.4 4.4 19.5 13.1 54.5 4.9 25.6 15.5 75.1 19.3 15.5 17.3 11.9 31.2 23.1 21.5 3.2 38.7 57.5 25.3 22.0 21.8 16.0 20.1 20.5 17.4 33.6 31.5 34.9 24.3 16.4 16.7 29.1 22.0 33.5 19.1 27.5 23.5 15.8 64.3 36.6 12.1 37.6 34.7 25.8 74.0 41.7 57.0 30.0 35.9 61.4 29.1 13.0 42.1 7.1 26.6 12.5 20.3 31.8 20.0 25.8 43.5 8.3 4.7 12.8 31.4 26.2 20.9 25.9 14.0 21.3 54.6 24.8 16.0 26.2 12.5 17.7 11.9 26.8 16.0 16.1 18.6 0.0 1.4 1.9 1.8 1.4 2.0 1.6 1.5 3.2 1.2 1.1 1.4 2.1 2.9 1.1 1.3 1.3 2.2 0.8 13.4 20.1 12.6 17.2 16.2 4.2 4.7 4.3 4.8 4.4 4.9 11.9 30.4 57.7 29.5 47.3 21.7 17.1 18.8 9.7 15.9 6.2 17.4 11.8 55.7 15.7 24.2 22.0 4.2 39.0 21.4 20.3 5.9 9.4 166.7 24.0 19.0 19.7 9.6 21.5 148.0 13.4 8.4 19.4 17.9 34.6 6.3 14.4 17.9 18.0 13.3 5.0 98.4 12.8 8.2 24.2 16.0 192.8 19.0 24.2 16.0 86.2 23.7 4.0 23.7 150.3 72.4 13.4 8.4 12.8 15.9 22.0 11.9 15.1 23.4 6.7 19.7 26.1 17.2 11.2 5.8 22.7 19.2 33.1 26.9 18.5 11.6 20.4 USP26 ENSG00000134588 "Ubiquitin specific peptidase 26" Q9BXU7 X 133024631-133097109 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 13 "Spermatogonia: 4.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA000424, HPA027310, HPA079124" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" Nucleoplasm Cytosol "HPA000424: , HPA027310: , HPA079124: " "unprognostic (7.92e-4)" "unprognostic (3.59e-2)" "unprognostic (1.99e-2)" "unprognostic (2.08e-1)" 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 USP27X USP27 ENSG00000273820 "Ubiquitin specific peptidase 27 X-linked" A6NNY8 X 49879484-49882558 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 14.4" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 19.2;Alveolar cells type 2: 15.5;Bipolar cells: 15.8;Cytotrophoblasts: 44.5;Syncytiotrophoblasts: 26.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "SuSa: 12.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA077264 Approved Nucleoplasm,Vesicles NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 12: NES - Nervous system development" "Cluster 47: Cytotrophoblasts - Unknown function" Vesicles Nucleoplasm "HPA077264: AB_2686831" "unprognostic (4.12e-2)" "unprognostic (9.58e-3)" "unprognostic (2.29e-1)" "unprognostic (4.66e-2)" "unprognostic (1.98e-1)" "unprognostic (1.74e-1)" "prognostic unfavorable (6.14e-4)" "unprognostic (3.10e-3)" "unprognostic (3.91e-2)" "unprognostic (1.31e-2)" "prognostic favorable (9.31e-4)" "unprognostic (5.37e-2)" "unprognostic (7.45e-3)" "unprognostic (1.19e-1)" "unprognostic (1.12e-1)" "unprognostic (2.01e-2)" "unprognostic (2.58e-1)" 1.6 2.5 6.0 1.3 6.2 0.5 2.0 8.0 5.8 3.0 3.1 3.2 1.0 3.9 2.9 1.6 3.5 1.6 1.8 5.3 14.4 2.7 1.8 2.7 1.7 4.9 8.4 6.3 2.6 3.0 7.3 11.7 5.9 3.0 1.4 3.8 1.6 2.8 4.4 2.1 2.1 2.8 3.6 1.8 2.4 1.3 10.5 2.6 2.4 2.1 1.7 3.0 2.2 4.4 1.6 3.8 4.2 4.8 3.8 3.1 3.6 1.6 2.6 1.8 1.4 6.9 1.6 0.9 1.6 4.2 6.0 2.6 6.0 4.0 2.6 2.0 3.1 1.6 1.1 6.2 2.6 0.5 3.4 4.4 2.7 2.6 2.6 4.4 2.5 4.2 3.4 1.5 2.9 3.7 2.5 1.2 4.8 2.7 2.7 2.7 3.7 0.3 2.9 1.4 1.1 3.2 3.4 3.0 4.0 12.9 3.5 1.1 1.9 2.1 4.3 3.8 0.7 1.6 0.4 0.6 2.5 1.4 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 6.0 6.2 8.0 5.8 5.3 14.4 4.9 8.4 5.9 3.6 10.5 4.4 3.5 19.2 15.5 0.7 2.5 2.9 4.5 0.3 2.2 15.8 1.9 2.7 2.6 0.0 7.5 0.0 0.0 44.5 1.4 1.7 5.9 1.5 0.1 2.1 4.1 5.2 4.2 0.0 2.9 0.7 3.6 2.7 1.1 2.1 2.5 4.0 2.5 1.9 4.0 5.0 3.3 1.3 0.0 0.6 1.0 0.3 2.1 1.2 0.0 0.0 1.5 8.3 0.0 3.5 0.8 1.2 0.5 3.4 0.5 3.3 0.5 2.9 13.2 2.5 6.6 2.5 2.6 0.2 1.3 0.9 2.3 26.1 2.0 8.8 1.6 1.7 USP28 KIAA1515 ENSG00000048028 "Ubiquitin specific peptidase 28" Q96RU2 11 113797874-113875570 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 62.7;skeletal muscle: 68.3;tongue: 66.5" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 152.2;Excitatory neurons: 57.0;NK-cells: 73.2" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebellum: 20.1" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006778, HPA006779" Enhanced Supported "Nucleoplasm,Nuclear bodies" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 38: Heart - Muscle contraction" "Cluster 12: NES - Nervous system development" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm "Nuclear bodies" "HPA006778: AB_1080520, HPA006779: AB_1080517" "unprognostic (2.54e-1)" "unprognostic (2.72e-1)" "unprognostic (2.99e-2)" "unprognostic (3.72e-2)" "unprognostic (5.51e-2)" "unprognostic (2.30e-1)" "unprognostic (9.73e-3)" "unprognostic (3.00e-1)" "unprognostic (2.04e-3)" "unprognostic (1.82e-3)" "unprognostic (3.17e-2)" "unprognostic (1.19e-1)" "unprognostic (5.11e-2)" "unprognostic (2.06e-2)" "unprognostic (9.03e-2)" "unprognostic (1.35e-3)" "unprognostic (5.03e-2)" 5.8 6.7 3.2 9.5 4.3 5.8 10.4 20.1 9.5 21.1 0.6 10.4 9.6 11.5 11.3 9.6 9.8 7.7 62.7 4.6 1.8 9.9 11.3 7.5 15.6 2.1 1.7 14.1 8.2 15.5 7.4 8.0 3.4 11.3 11.7 27.1 12.0 14.2 68.3 7.0 10.4 13.1 1.2 13.8 9.2 9.2 1.9 9.0 10.1 66.5 15.5 9.8 8.4 5.3 18.3 20.2 26.7 35.4 21.3 20.9 18.8 13.2 18.0 17.5 29.7 30.2 25.6 24.2 29.3 18.0 40.1 35.1 37.9 24.8 24.1 27.1 17.2 12.9 13.8 16.3 13.0 16.8 12.4 12.6 18.5 20.2 23.8 25.4 32.0 11.9 22.7 15.3 18.5 9.3 12.9 27.1 32.0 33.6 14.4 31.3 37.1 29.4 19.3 17.8 11.6 12.6 31.4 10.7 10.1 82.7 25.8 5.8 17.1 19.2 28.3 17.8 13.8 10.4 15.9 20.1 1.9 32.1 12.8 0.2 5.0 3.4 23.2 3.7 12.1 15.5 5.7 16.8 6.4 12.3 3.8 13.1 1.4 28.6 6.4 1.9 9.2 10.3 3.2 4.3 20.1 9.5 4.6 1.8 2.1 1.7 3.4 1.2 1.9 5.3 7.3 9.6 8.8 18.3 17.8 1.7 7.3 9.9 13.6 18.7 9.7 9.8 152.2 5.7 9.9 5.5 18.8 4.4 32.1 3.3 5.9 6.7 1.7 6.6 11.6 7.9 4.9 2.5 57.0 3.9 4.7 12.2 11.7 8.7 1.3 18.9 7.5 8.8 4.4 5.0 34.1 9.6 4.1 6.5 2.5 2.0 6.8 7.4 1.8 10.3 8.2 10.3 73.2 29.1 21.3 3.5 5.3 13.9 21.7 7.1 7.3 7.1 14.6 21.5 6.6 10.3 11.0 15.8 11.4 7.7 2.0 1.1 18.6 9.0 8.9 5.8 USP29 ENSG00000131864 "Ubiquitin specific peptidase 29" Q9HBJ7 19 57119138-57131926 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "testis: 4.9" "Group enriched" "Detected in some" 8 "Collecting duct cells: 1.8;Early spermatids: 2.2;Spermatocytes: 5.1;Spermatogonia: 1.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected" "Not detected" HPA076515 Enhanced NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 21: Non-specific - Transcription" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA076515: " "unprognostic (1.32e-1)" 0.1 0.0 0.9 0.0 0.5 1.8 0.0 2.1 0.6 0.0 1.0 0.1 0.1 0.2 0.0 0.2 0.1 0.2 0.5 1.0 1.0 0.1 0.1 0.2 0.4 1.9 0.9 0.3 1.3 0.0 0.0 0.2 0.8 0.1 0.1 0.6 0.7 0.0 0.3 1.4 0.0 0.0 0.8 0.2 0.4 4.9 0.8 0.0 0.3 0.0 0.1 0.3 0.0 2.0 0.0 0.2 0.2 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.3 0.9 0.2 0.0 0.0 0.3 0.0 0.5 0.2 0.3 0.4 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.2 0.0 0.3 0.0 0.1 0.3 0.2 0.0 0.2 0.0 0.6 0.5 0.2 0.1 0.1 0.1 0.3 0.2 0.3 0.4 0.3 0.1 0.0 0.0 0.4 0.1 0.3 0.1 0.2 0.0 1.3 0.3 0.3 0.2 0.2 0.1 0.2 0.1 0.1 0.1 0.2 0.1 0.1 1.1 0.3 0.1 0.6 0.1 0.2 0.9 0.5 2.1 0.6 1.0 1.0 1.9 0.9 0.8 0.8 0.8 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 5.1 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.2 USP3 ENSG00000140455 "Ubiquitin specific peptidase 3" Q9Y6I4 15 63504511-63594640 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, DNA damage, Ubl conjugation pathway" "Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in all" 4 "cerebellum: 36.4" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA053275, HPA060513, HPA077975" Supported "Nucleoplasm,Midbody ring" "Intracellular and membrane" Yes No "Cluster 1: Neutrophils - Mixed function" "Cluster 50: Non-specific - Ribosome" "Cluster 15: RT4 - Unknown function" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Nucleoplasm "Midbody ring" "HPA053275: AB_2682096, HPA060513: AB_2684299, HPA077975: AB_2732365" "unprognostic (4.63e-3)" "unprognostic (2.71e-1)" "unprognostic (7.88e-2)" "unprognostic (3.33e-2)" "unprognostic (2.16e-2)" "unprognostic (6.03e-2)" "unprognostic (6.26e-2)" "unprognostic (4.52e-2)" "unprognostic (1.62e-2)" "unprognostic (2.36e-1)" "unprognostic (3.54e-2)" "unprognostic (4.87e-2)" "unprognostic (1.17e-1)" "unprognostic (8.61e-2)" "unprognostic (2.78e-1)" "unprognostic (6.21e-2)" "prognostic favorable (1.38e-4)" 12.7 8.2 5.8 5.4 7.0 21.4 11.2 36.4 5.9 11.7 15.4 13.4 6.5 12.9 4.7 10.9 10.9 5.4 6.0 5.3 6.3 10.1 8.2 13.2 6.5 6.9 6.9 16.2 18.9 3.1 6.2 2.7 7.6 10.4 5.6 6.3 12.4 6.0 10.0 14.6 13.9 4.5 5.3 17.6 15.7 5.3 8.6 7.4 9.1 3.6 6.4 12.4 11.9 7.5 10.4 21.0 12.1 8.1 5.5 7.6 8.2 6.7 9.6 7.1 5.8 6.6 13.1 8.7 15.3 9.3 3.6 12.0 11.6 11.1 5.6 12.2 5.8 10.4 8.6 9.8 6.8 6.4 11.4 11.3 7.8 7.7 10.6 8.9 12.4 17.3 9.5 9.0 3.3 5.2 11.0 8.8 16.2 13.7 5.3 22.2 8.4 11.3 4.5 23.8 9.6 9.5 3.3 13.0 6.7 7.8 5.5 9.5 13.4 7.2 16.9 3.3 10.3 9.3 24.4 18.2 7.4 13.8 7.5 120.0 84.7 12.7 24.8 66.0 28.4 34.1 34.3 26.0 59.8 34.8 34.0 25.2 169.1 19.8 65.4 13.1 28.1 45.2 5.8 7.0 36.4 5.9 5.3 6.3 6.9 6.9 7.6 5.3 8.6 7.5 23.6 38.5 69.2 76.7 63.4 52.6 34.3 24.8 23.3 31.4 27.9 20.3 9.2 25.8 41.4 16.5 12.5 19.8 48.4 37.6 41.1 41.0 21.6 37.8 32.8 26.0 43.8 15.8 11.2 37.2 57.3 28.3 39.8 74.6 27.1 64.5 11.4 24.0 24.8 13.5 40.0 35.4 30.5 78.4 109.6 77.4 15.8 74.5 42.7 75.9 101.8 25.9 41.2 80.4 40.6 39.8 35.6 18.4 69.7 40.6 33.2 28.3 33.3 17.9 13.1 25.3 34.5 14.8 40.3 33.9 59.0 34.1 64.6 40.1 40.6 37.6 USP30 "FLJ40511, MGC10702" ENSG00000135093 "Ubiquitin specific peptidase 30" Q70CQ3 12 109023089-109088023 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 52.7;Oligodendrocytes: 41.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016952 Approved NA NA "Cluster 44: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 25: Spermatids - Spermatogenesis" "HPA016952: AB_1858680" "unprognostic (2.34e-1)" "unprognostic (1.57e-2)" "unprognostic (7.04e-2)" "unprognostic (9.91e-2)" "unprognostic (2.48e-1)" "unprognostic (5.89e-2)" "unprognostic (1.91e-1)" "unprognostic (3.60e-3)" "unprognostic (1.98e-1)" "unprognostic (4.96e-2)" "unprognostic (5.07e-2)" "unprognostic (1.07e-1)" "prognostic favorable (5.23e-6)" "unprognostic (2.49e-1)" "unprognostic (1.23e-1)" "unprognostic (1.12e-1)" "unprognostic (1.02e-3)" 8.4 8.8 2.9 7.3 6.0 10.7 6.5 4.2 5.4 6.6 1.9 10.2 11.4 7.8 4.7 5.6 8.0 5.9 6.8 3.3 6.9 9.1 16.3 6.8 8.8 5.2 4.3 12.4 8.6 14.4 4.2 5.1 5.5 6.8 8.4 10.7 7.7 6.7 10.0 6.6 11.1 6.2 3.0 7.9 6.5 13.8 5.0 6.3 8.2 8.7 4.5 4.3 3.3 14.1 5.3 4.1 10.7 9.2 7.3 8.3 5.9 5.9 7.8 6.8 5.9 4.9 3.9 13.6 4.8 5.9 6.1 5.6 9.4 6.3 7.7 16.0 11.7 4.2 3.8 7.1 7.8 8.7 4.6 10.1 7.4 5.9 6.0 17.5 8.0 13.8 6.8 6.1 5.9 6.3 13.8 5.0 3.2 6.3 11.3 14.7 7.6 8.1 5.4 6.4 9.7 8.6 8.0 5.6 6.3 7.8 14.5 6.8 5.5 5.9 3.3 5.9 3.7 16.0 14.4 19.3 6.5 5.0 6.9 14.0 8.4 16.2 17.5 14.0 20.2 17.3 14.7 16.8 5.6 17.0 15.2 14.1 5.1 23.3 11.7 15.2 14.4 7.4 2.9 6.0 4.2 5.4 3.3 6.9 5.2 4.3 5.5 3.0 5.0 14.1 3.9 0.0 4.6 10.7 2.5 2.0 2.2 4.1 6.2 9.1 4.8 4.1 8.6 10.0 5.6 5.5 8.4 5.7 3.4 14.3 0.0 4.7 27.3 3.6 3.8 3.6 6.7 5.7 18.8 5.7 4.2 4.4 1.5 3.2 0.0 11.8 4.2 18.3 5.7 6.7 22.7 8.4 0.0 3.5 1.4 52.7 3.7 2.2 1.8 7.5 3.5 6.9 4.1 16.6 41.8 5.3 5.6 3.8 6.7 1.9 13.3 7.3 5.2 14.9 13.1 5.2 3.5 26.1 5.6 4.7 3.3 7.3 3.4 5.0 9.9 2.7 USP31 KIAA1203 ENSG00000103404 "Ubiquitin specific peptidase 31" Q70CQ4 16 23061406-23149270 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 31.2" "Cell type enhanced" "Detected in many" "Oligodendrocytes: 198.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006937 Uncertain Approved Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 30: Epithelial cell lines - Translation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "HPA006937: AB_1080523" "unprognostic (6.45e-2)" "unprognostic (2.42e-1)" "unprognostic (1.08e-1)" "unprognostic (4.43e-3)" "unprognostic (1.24e-1)" "unprognostic (1.28e-1)" "unprognostic (1.23e-1)" "unprognostic (1.29e-1)" "unprognostic (1.03e-1)" "unprognostic (2.52e-1)" "unprognostic (6.15e-2)" "unprognostic (2.01e-1)" "prognostic unfavorable (4.41e-5)" "unprognostic (5.59e-2)" "unprognostic (3.75e-1)" "unprognostic (3.07e-1)" "unprognostic (1.98e-3)" 5.5 2.9 7.5 2.0 23.4 4.3 6.7 18.9 13.0 12.9 0.7 4.2 1.7 11.0 3.8 6.0 5.3 1.9 9.2 10.0 10.5 3.6 5.6 6.1 1.8 22.3 20.3 2.2 4.3 5.5 5.7 3.9 21.3 7.5 2.3 3.2 4.6 4.1 8.9 11.2 2.6 7.5 11.3 1.6 2.6 11.8 20.6 2.6 3.0 8.4 2.5 7.5 7.9 31.2 12.0 12.4 3.5 4.9 6.2 4.8 3.3 4.1 3.7 5.1 6.1 7.9 7.1 4.0 4.2 5.1 8.3 15.2 8.7 15.9 8.4 2.9 3.5 1.6 7.4 16.7 7.8 4.2 4.3 4.1 13.5 9.5 21.8 1.9 9.3 3.9 4.9 12.0 7.1 8.0 2.0 3.5 6.9 3.9 3.8 9.9 9.8 7.9 7.7 17.5 9.3 6.0 6.3 12.4 3.6 3.9 5.0 9.2 5.5 10.3 7.6 5.3 11.2 3.9 7.0 4.2 7.4 5.5 4.2 0.0 0.1 0.1 0.1 0.0 0.3 0.0 0.1 0.2 0.1 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.2 0.0 7.5 23.4 18.9 13.0 10.0 10.5 22.3 20.3 21.3 11.3 20.6 31.2 25.9 6.4 3.7 11.1 2.2 66.8 62.7 35.5 44.9 13.7 7.6 19.8 13.6 7.2 10.9 5.5 2.1 13.8 3.6 2.7 0.0 7.0 4.8 20.6 12.8 17.6 4.8 8.2 59.2 8.6 7.5 6.9 2.0 13.2 1.3 23.7 7.5 27.7 4.7 0.0 49.6 3.5 12.2 3.5 10.8 10.4 7.8 5.0 7.2 32.8 3.1 4.0 3.1 31.7 198.7 7.9 2.0 4.5 2.8 32.0 1.5 11.6 17.6 8.1 19.7 8.8 11.2 24.2 57.1 17.4 26.6 7.5 2.9 4.4 6.4 23.9 USP32 "NY-REN-60, USP10" ENSG00000170832 "Ubiquitin specific peptidase 32" Q8NFA0 17 60177327-60422470 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 102.1" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 241.8;Inhibitory neurons: 113.1;Oligodendrocytes: 268.9;Rod photoreceptor cells: 136.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "plasmacytoid DC: 59.2" "Group enriched" "Detected in all" 10 "dendritic cells: 59.2;granulocytes: 29.4" "Cell line enhanced" "Detected in all" "MCF7: 171.4" "Low region specificity" "Detected in all" HPA044365 Approved Approved "Golgi apparatus,Cytosol" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 77: Retina - Visual perception" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 9: Photoreceptor cells - Phototransduction" "Golgi apparatus" Cytosol "HPA044365: AB_2678914" "unprognostic (4.10e-2)" "unprognostic (3.38e-2)" "unprognostic (3.57e-2)" "prognostic unfavorable (1.50e-4)" "unprognostic (2.15e-1)" "unprognostic (4.33e-2)" "unprognostic (1.90e-3)" "unprognostic (2.33e-2)" "unprognostic (2.24e-1)" "unprognostic (3.93e-1)" "unprognostic (6.49e-2)" "unprognostic (2.78e-1)" "unprognostic (2.82e-1)" "unprognostic (1.97e-1)" "unprognostic (7.23e-2)" "unprognostic (8.35e-2)" "unprognostic (4.16e-2)" 16.1 21.8 13.6 15.0 27.8 32.1 14.1 23.2 23.6 12.4 25.2 13.0 9.5 10.3 6.8 21.7 10.7 11.8 17.4 14.3 22.8 20.2 26.6 20.7 10.5 22.2 25.0 10.0 12.5 19.2 11.9 13.2 24.8 10.8 11.4 58.8 12.9 11.2 40.8 21.0 10.5 13.7 18.1 18.5 12.2 102.1 22.3 14.4 20.6 29.2 11.6 13.1 14.7 44.4 32.6 38.2 19.0 30.8 44.8 45.3 17.2 26.4 41.9 34.5 45.8 18.6 20.0 19.4 21.5 50.0 56.1 16.3 33.1 36.9 61.5 16.8 13.9 39.7 31.8 19.5 44.1 31.7 33.6 39.6 24.6 49.9 45.2 33.5 38.6 24.4 42.9 17.1 41.1 171.4 32.3 21.3 21.7 29.6 18.8 15.8 51.6 11.5 33.1 24.5 13.1 19.1 22.9 6.0 33.8 32.1 27.4 41.3 32.6 49.7 54.9 33.1 23.5 16.2 37.4 19.6 24.6 23.6 33.4 14.5 4.3 16.5 2.0 3.7 1.4 3.0 1.4 1.7 8.5 2.2 1.0 1.9 29.4 1.3 4.6 59.2 2.6 2.1 13.6 27.8 23.2 23.6 14.3 22.8 22.2 25.0 24.8 18.1 22.3 44.4 8.0 6.4 16.4 58.8 12.5 26.9 13.3 5.8 11.4 17.3 9.2 7.6 8.2 10.0 10.1 5.5 241.8 5.1 12.6 8.5 3.9 11.3 95.0 9.0 9.9 9.8 8.3 44.2 92.3 7.5 8.4 12.6 15.8 11.6 11.4 18.5 12.5 12.0 18.5 13.5 113.1 5.6 6.1 29.7 41.3 33.3 13.1 25.1 5.4 101.2 28.0 10.4 24.7 70.4 268.9 9.6 11.4 5.7 8.3 10.3 7.4 4.6 7.0 136.4 26.3 11.9 9.1 92.7 14.9 11.2 21.9 4.9 10.9 8.5 5.5 8.2 USP33 "KIAA1097, VDU1" ENSG00000077254 "Ubiquitin specific peptidase 33" Q8TEY7 1 77695987-77759852 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Endocytosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Inhibitory neurons: 159.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005719 Uncertain Supported "Nucleoplasm,Golgi apparatus" NA NA "Cluster 42: Non-specific - Transcription" "Cluster 6: Brain - Smell perception" "Cluster 36: HEL - Hemostasis" "Cluster 50: Fibroblasts - ECM organization" "Nucleoplasm, Golgi apparatus" "HPA005719: AB_10601708" "unprognostic (2.31e-3)" "unprognostic (2.73e-2)" "unprognostic (1.04e-2)" "unprognostic (2.36e-1)" "unprognostic (9.19e-3)" "unprognostic (1.88e-3)" "unprognostic (1.22e-2)" "unprognostic (6.06e-2)" "unprognostic (2.48e-1)" "unprognostic (2.25e-1)" "unprognostic (2.67e-1)" "unprognostic (3.59e-1)" "unprognostic (5.36e-3)" "unprognostic (4.89e-2)" "unprognostic (5.76e-2)" "unprognostic (2.19e-1)" "unprognostic (2.02e-2)" 40.7 31.2 31.5 24.6 40.4 34.5 34.3 52.0 49.7 24.2 37.3 24.3 25.4 28.0 26.8 21.6 22.5 26.3 21.7 35.4 31.8 31.1 25.4 26.2 28.1 28.6 24.9 29.3 19.5 35.0 20.9 28.0 30.8 28.8 25.2 49.1 25.2 22.9 18.0 24.3 26.9 24.1 22.3 26.0 24.4 25.4 28.6 27.1 30.4 20.7 26.0 22.9 20.0 55.5 42.4 18.8 64.1 44.2 90.0 78.3 54.8 45.3 42.9 54.0 60.1 25.4 35.5 31.4 41.2 44.3 88.2 32.1 47.4 31.1 65.7 28.8 36.6 111.1 44.6 22.2 56.0 37.8 26.8 58.3 23.9 52.4 37.9 51.9 48.7 28.0 43.9 26.3 41.2 16.1 34.9 38.0 62.2 32.6 37.2 33.0 67.7 22.2 51.0 41.1 53.8 41.2 31.9 41.5 64.2 54.3 23.1 41.2 41.2 49.4 34.4 50.1 43.2 21.0 28.4 30.4 37.3 44.5 25.4 67.3 22.5 31.8 21.0 22.6 21.7 20.5 20.6 21.7 17.5 22.3 24.5 21.9 30.5 19.2 30.1 18.4 20.7 16.7 31.5 40.4 52.0 49.7 35.4 31.8 28.6 24.9 30.8 22.3 28.6 55.5 40.2 44.8 40.9 66.3 35.1 17.2 18.8 21.2 32.5 56.7 25.7 22.1 39.9 22.8 25.5 35.0 58.4 25.1 48.8 35.9 9.8 20.8 4.3 54.8 37.8 31.8 35.5 50.9 149.3 15.4 19.0 39.6 43.3 54.6 23.4 43.1 28.2 23.1 19.0 62.2 159.0 28.6 22.4 30.8 20.7 5.5 35.8 35.1 23.2 75.9 38.7 31.4 37.0 98.0 138.5 19.6 27.8 32.0 42.4 22.9 33.2 25.6 37.3 44.5 19.7 34.9 35.6 39.8 30.1 28.4 16.3 11.9 41.0 39.2 24.8 21.8 USP34 "KIAA0570, KIAA0729" ENSG00000115464 "Ubiquitin specific peptidase 34" Q70CQ2 2 61187463-61471087 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 310.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA025815, HPA070764" Uncertain Approved Nucleoplasm NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 52: Non-specific - Transcription" Nucleoplasm "HPA025815: AB_1858681, HPA070764: AB_2686308" "unprognostic (4.04e-2)" "unprognostic (8.21e-3)" "unprognostic (5.08e-2)" "unprognostic (3.14e-2)" "unprognostic (4.13e-2)" "unprognostic (1.43e-2)" "unprognostic (1.04e-1)" "unprognostic (2.66e-1)" "unprognostic (1.47e-1)" "unprognostic (2.90e-2)" "unprognostic (8.91e-2)" "unprognostic (4.62e-2)" "unprognostic (9.58e-2)" "unprognostic (1.66e-1)" "unprognostic (2.53e-1)" "unprognostic (6.34e-2)" "unprognostic (7.01e-2)" 32.2 36.0 49.9 21.7 53.9 37.7 35.6 57.7 58.3 36.1 59.9 47.0 14.8 38.4 54.4 35.8 33.3 21.1 33.7 49.7 53.5 43.3 34.8 36.4 44.1 52.1 51.8 43.4 32.4 35.1 45.0 17.4 52.3 38.6 26.8 77.5 27.2 32.4 53.9 41.4 40.8 27.9 50.3 45.8 36.3 45.1 54.5 47.8 32.2 36.8 45.1 36.9 32.8 56.8 43.6 29.9 38.9 40.3 71.8 48.1 32.4 26.3 37.1 23.0 21.7 43.0 16.3 102.2 27.0 56.9 24.3 23.4 30.9 34.4 42.6 36.7 24.4 61.6 29.5 69.6 60.2 46.1 37.8 52.9 43.6 41.9 62.1 55.7 49.0 28.8 42.7 32.2 51.5 40.6 30.6 66.6 26.3 43.9 23.9 32.4 46.5 27.7 67.9 52.2 31.9 34.0 40.5 30.1 48.3 49.4 16.0 33.2 43.6 36.1 48.2 21.5 34.7 37.0 19.7 103.6 33.8 42.5 31.7 2.1 1.2 1.6 3.8 1.1 3.5 2.6 2.6 2.9 1.0 3.1 2.9 3.9 1.8 3.1 2.8 3.2 2.5 1.4 49.9 53.9 57.7 58.3 49.7 53.5 52.1 51.8 52.3 50.3 54.5 56.8 64.5 64.1 68.3 193.6 82.8 61.1 54.2 40.3 46.7 139.7 54.0 46.6 46.0 48.6 54.6 33.1 250.2 33.5 87.3 46.0 9.8 41.4 133.5 59.9 66.9 59.3 48.6 53.2 256.6 33.6 23.8 53.0 73.9 70.6 32.3 78.0 31.8 38.9 21.6 107.7 240.4 37.8 59.0 45.4 48.6 138.0 56.8 56.0 40.9 212.7 55.2 60.0 87.6 232.2 310.0 49.9 41.1 67.0 69.9 79.9 38.3 23.4 44.1 178.1 26.3 78.2 63.9 95.8 115.9 53.1 61.4 53.4 70.5 74.7 35.6 69.9 USP35 KIAA1372 ENSG00000118369 "Ubiquitin specific peptidase 35" Q9P2H5 11 78188812-78215232 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 9 "Early spermatids: 39.1;Granulosa cells: 30.8;Late spermatids: 121.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA055213, HPA058592" Uncertain Approved "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 31: Spermatids - Spermatogenesis" "Nucleoli fibrillar center" Nucleoplasm "HPA055213: AB_2682740, HPA058592: AB_2683766" "unprognostic (6.69e-2)" "unprognostic (1.17e-2)" "unprognostic (1.69e-1)" "unprognostic (6.87e-3)" "unprognostic (3.38e-2)" "unprognostic (1.08e-2)" "unprognostic (2.00e-1)" "unprognostic (1.46e-1)" "unprognostic (3.57e-2)" "unprognostic (3.84e-3)" "unprognostic (1.03e-2)" "unprognostic (3.11e-2)" "unprognostic (1.29e-3)" "unprognostic (2.93e-1)" "unprognostic (1.31e-1)" "unprognostic (4.38e-2)" "unprognostic (1.49e-2)" 6.1 19.8 8.0 3.6 7.4 2.5 5.1 5.1 8.0 9.2 7.4 7.6 3.5 6.7 3.2 6.0 6.4 3.5 10.2 8.3 7.1 6.2 16.8 7.0 3.3 9.0 8.2 7.4 5.9 12.4 13.4 4.7 9.4 5.9 1.9 2.1 3.9 3.2 4.1 3.0 4.5 4.7 3.9 4.9 4.6 4.5 8.3 6.2 8.7 4.0 2.6 6.6 7.7 6.4 2.2 3.3 5.7 6.1 9.7 8.7 3.9 5.0 5.8 5.8 4.0 8.4 4.7 1.7 5.0 9.5 6.2 5.8 3.8 7.8 3.4 12.8 2.0 2.9 9.8 5.0 7.4 1.8 8.3 7.4 5.1 12.1 3.5 11.4 7.2 6.5 4.1 4.2 4.6 2.0 4.7 7.6 1.7 6.2 5.3 2.9 5.2 2.0 4.5 4.1 2.8 5.9 3.9 5.1 1.9 8.1 4.3 1.6 8.9 10.6 5.9 12.8 2.7 5.7 2.0 2.7 3.1 2.0 6.3 0.0 0.0 0.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.0 7.4 5.1 8.0 8.3 7.1 9.0 8.2 9.4 3.9 8.3 6.4 1.3 0.0 1.8 5.9 1.2 0.8 0.2 0.7 3.4 0.8 1.0 0.6 3.5 0.0 0.3 0.0 6.2 0.7 1.0 1.2 0.0 1.1 39.1 1.3 2.7 1.9 0.0 0.4 5.2 2.0 1.6 2.0 5.1 1.2 0.0 30.8 1.4 2.7 1.6 0.0 4.8 0.9 0.0 0.6 0.8 121.6 1.5 1.4 1.8 2.8 2.7 0.4 0.0 3.5 2.8 2.0 0.1 3.0 0.8 0.3 0.8 1.0 0.5 0.6 6.6 0.7 1.3 1.2 2.4 4.1 1.0 0.3 2.9 2.1 1.3 0.2 USP36 "FLJ12851, KIAA1453" ENSG00000055483 "Ubiquitin specific peptidase 36" Q9P275 17 78787381-78841441 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012082, HPA012395, HPA052860" Uncertain Supported Enhanced "Nucleoli,Nucleoli rim,Nuclear speckles" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 50: Non-specific - Ribosome" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 24: Non-specific - Transcription regulation" "Nucleoli, Nucleoli rim" "Nuclear speckles" "HPA012082: AB_1858682, HPA012395: , HPA052860: AB_2681974" "unprognostic (1.94e-2)" "unprognostic (2.80e-2)" "unprognostic (1.07e-1)" "prognostic unfavorable (5.18e-5)" "unprognostic (9.35e-2)" "unprognostic (1.98e-1)" "unprognostic (2.50e-3)" "unprognostic (1.35e-1)" "unprognostic (2.04e-1)" "unprognostic (1.33e-1)" "unprognostic (1.68e-2)" "unprognostic (2.78e-2)" "unprognostic (1.31e-2)" "unprognostic (1.45e-1)" "unprognostic (1.81e-1)" "unprognostic (4.03e-3)" "unprognostic (1.78e-1)" 43.9 37.9 20.0 21.5 21.9 46.6 32.9 29.3 23.9 32.6 27.5 31.2 13.4 26.8 22.9 25.0 34.2 18.7 30.2 21.4 20.6 34.4 30.3 36.1 20.6 22.6 21.3 67.4 44.5 18.1 50.3 26.0 21.5 36.2 15.8 26.3 24.9 13.1 30.3 40.4 26.6 16.3 19.4 30.7 31.2 22.2 21.2 15.1 31.6 11.7 20.5 29.3 29.8 30.1 42.7 50.3 14.6 26.9 30.5 33.7 27.8 34.1 34.5 32.1 21.5 49.2 21.0 54.0 16.9 30.6 34.8 30.6 34.5 25.4 57.0 13.0 52.1 49.4 81.0 51.9 31.3 54.7 26.0 29.5 41.0 45.8 101.6 24.7 28.3 24.1 40.0 55.3 26.8 32.6 50.1 55.1 22.6 31.6 39.9 38.1 31.8 36.3 20.2 44.1 42.8 25.8 24.5 112.5 63.7 31.3 29.2 34.4 24.3 75.2 35.3 44.3 61.1 40.7 17.4 66.1 29.6 41.9 24.0 10.1 3.0 2.4 5.5 4.2 6.5 5.1 5.2 4.8 1.8 4.7 5.7 5.6 4.3 4.5 2.7 9.7 3.8 1.9 20.0 21.9 29.3 23.9 21.4 20.6 22.6 21.3 21.5 19.4 21.2 30.1 27.4 12.8 37.4 23.5 55.9 51.7 28.4 8.2 40.9 33.2 18.1 16.9 14.1 18.6 18.8 14.7 33.3 8.3 66.3 14.4 5.9 10.2 20.7 22.3 24.0 28.4 18.5 14.7 19.0 9.6 11.3 26.6 25.0 42.7 20.3 12.8 12.1 16.5 43.3 26.9 22.5 18.6 10.2 24.5 72.8 8.5 11.8 49.4 30.2 10.3 14.9 13.2 16.5 13.6 19.8 13.2 8.4 12.4 57.1 32.4 7.3 5.0 11.1 32.1 6.6 22.1 23.1 18.4 16.5 24.4 43.3 12.9 73.6 13.1 18.6 22.2 USP37 KIAA1594 ENSG00000135913 "Ubiquitin specific peptidase 37" Q86T82 2 218450251-218568351 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 119.4;Late spermatids: 145.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045160 Approved Approved Nucleoplasm,Nucleoli NA Yes "Cluster 44: Non-specific - Transcription" "Cluster 6: Brain - Smell perception" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Nucleoli" "HPA045160: AB_10795620" "unprognostic (7.00e-2)" "unprognostic (2.29e-1)" "unprognostic (8.83e-2)" "unprognostic (9.19e-4)" "unprognostic (1.83e-1)" "prognostic favorable (2.85e-4)" "unprognostic (2.18e-2)" "unprognostic (1.14e-1)" "unprognostic (9.66e-3)" "unprognostic (1.17e-1)" "unprognostic (3.78e-3)" "unprognostic (1.11e-1)" "unprognostic (3.82e-2)" "unprognostic (3.26e-1)" "unprognostic (2.87e-1)" "unprognostic (6.69e-2)" "unprognostic (6.41e-3)" 2.7 4.1 3.5 4.4 4.7 11.8 4.7 8.5 4.9 3.6 1.9 3.0 2.9 4.2 7.5 3.9 3.3 3.5 2.3 3.3 4.0 2.9 3.8 3.0 6.0 3.8 4.0 5.9 3.0 4.0 1.4 4.0 4.0 3.6 3.5 9.1 3.9 3.0 2.9 3.9 3.3 3.2 2.5 3.8 3.4 12.7 3.4 6.3 5.0 4.2 4.9 3.6 2.2 8.3 9.6 6.9 14.2 11.0 3.6 4.4 12.1 7.1 5.1 12.2 13.6 13.1 7.4 8.7 7.5 5.6 9.3 8.9 15.7 8.0 13.4 12.0 8.3 23.5 13.6 8.7 4.1 15.6 11.3 2.4 4.7 12.9 9.2 4.5 5.3 15.0 17.3 16.2 7.8 7.2 20.1 10.6 12.2 6.2 5.9 16.0 21.3 8.0 4.2 11.2 15.5 8.4 11.5 5.6 7.2 13.6 6.4 10.8 6.8 13.7 12.0 7.7 9.5 11.0 10.4 17.6 7.4 11.2 9.5 4.2 2.0 3.8 3.1 2.3 3.2 2.5 2.6 2.7 2.1 3.2 4.0 2.6 1.6 3.2 2.2 2.9 3.6 1.2 3.5 4.7 8.5 4.9 3.3 4.0 3.8 4.0 4.0 2.5 3.4 8.3 12.8 0.0 11.0 34.3 16.5 19.5 7.0 7.1 22.2 14.7 14.4 10.2 4.9 4.3 9.6 7.3 27.1 8.4 13.4 5.5 0.0 5.8 119.4 13.3 11.8 14.2 10.3 16.6 47.4 2.3 6.6 13.2 9.2 16.4 5.1 16.2 12.5 11.0 7.8 15.2 40.0 8.9 4.1 8.5 22.9 145.5 9.9 17.2 21.4 27.2 10.2 9.1 10.3 35.2 60.5 4.9 7.4 9.8 14.6 12.1 7.1 4.2 11.1 19.9 6.6 12.7 21.6 60.8 31.4 13.6 20.6 7.3 19.7 10.9 7.6 7.1 USP38 "HP43.8KD, KIAA1891" ENSG00000170185 "Ubiquitin specific peptidase 38" Q8NB14 4 143184917-143223874 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 36.6" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-266/84: 65.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036990, HPA047948" Uncertain Approved Nucleoplasm,Centrosome,Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 16: U-266 - Nucleosome" "Cluster 44: Endometrium - Transcription" Nucleoplasm "Centrosome, Cytosol" "HPA036990: AB_2675419, HPA047948: AB_2680220" "unprognostic (5.01e-2)" "unprognostic (2.45e-1)" "unprognostic (2.04e-3)" "unprognostic (2.99e-2)" "unprognostic (1.87e-1)" "unprognostic (2.61e-2)" "unprognostic (1.67e-1)" "unprognostic (7.49e-2)" "unprognostic (3.66e-2)" "unprognostic (3.97e-2)" "unprognostic (8.03e-2)" "unprognostic (7.72e-3)" "prognostic favorable (1.20e-4)" "unprognostic (3.15e-1)" "unprognostic (1.26e-1)" "unprognostic (1.29e-1)" "unprognostic (1.02e-1)" 6.5 4.4 2.5 6.2 4.3 21.6 4.6 4.3 2.9 6.2 4.3 8.0 7.9 5.5 2.3 7.0 4.3 5.2 6.8 2.2 2.4 7.0 13.2 6.3 6.4 5.9 3.8 3.7 8.2 7.7 3.3 8.1 4.9 5.5 5.7 4.5 5.8 5.6 36.6 5.9 7.2 5.7 4.9 7.4 6.3 6.8 3.2 9.3 7.4 21.3 5.8 6.8 3.9 6.8 8.5 7.9 6.6 11.3 8.4 8.2 5.1 13.0 12.5 11.8 10.1 23.1 11.7 10.5 9.2 11.5 7.8 6.5 15.9 13.5 10.2 26.0 10.5 9.7 8.5 4.7 11.3 19.4 9.4 10.2 11.1 12.0 9.5 8.3 12.2 11.9 21.5 31.5 7.9 13.3 25.6 3.7 6.1 17.7 15.3 16.7 10.2 10.1 7.2 9.2 13.8 12.3 10.5 17.3 10.9 4.9 10.8 7.6 14.6 10.8 9.1 9.6 14.1 35.7 65.3 18.6 10.9 14.4 9.3 13.4 4.5 9.7 5.7 4.6 7.0 4.6 4.9 4.9 6.6 4.5 4.8 4.2 4.3 10.1 4.9 2.7 7.9 4.3 2.5 4.3 4.3 2.9 2.2 2.4 5.9 3.8 4.9 4.9 3.2 6.8 21.5 22.4 19.8 13.7 19.5 53.5 21.0 6.2 25.6 7.4 20.8 13.7 18.4 10.0 12.2 0.0 12.5 12.8 22.2 35.5 1.9 8.3 36.4 20.7 26.1 15.3 30.6 31.5 19.6 7.7 7.1 13.4 26.0 52.1 3.8 9.9 17.9 38.4 10.6 8.4 15.9 20.2 4.1 17.0 16.6 20.3 6.8 21.9 12.4 9.4 10.1 15.1 12.3 18.6 22.8 10.2 13.4 9.4 38.6 16.8 17.0 18.5 10.9 8.9 13.1 15.0 14.1 11.3 4.7 31.5 59.1 26.7 23.2 11.0 17.6 45.4 USP39 "CGI-21, SAD1, SNRNP65" ENSG00000168883 "Ubiquitin specific peptidase 39" Q53GS9 2 85602856-85649283 "Enzymes, Predicted intracellular proteins" "Cell cycle, Cell division, mRNA processing, mRNA splicing" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034823, HPA077350" Supported Supported Supported Nucleoplasm NA NA "Cluster 44: Non-specific - Transcription" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Nucleoplasm "HPA034823: AB_10602488, HPA077350: " "unprognostic (1.10e-2)" "unprognostic (3.31e-3)" "unprognostic (1.83e-1)" "prognostic unfavorable (5.52e-4)" "unprognostic (8.46e-3)" "unprognostic (3.67e-2)" "prognostic unfavorable (2.84e-6)" "unprognostic (1.10e-2)" "unprognostic (1.69e-1)" "unprognostic (1.89e-1)" "unprognostic (5.17e-3)" "unprognostic (3.14e-2)" "prognostic unfavorable (4.05e-7)" "unprognostic (3.95e-3)" "unprognostic (2.25e-1)" "unprognostic (2.52e-2)" "unprognostic (2.52e-1)" 22.6 16.1 18.1 19.8 18.7 40.8 21.3 19.0 20.6 22.2 22.7 24.2 17.1 23.5 26.1 22.7 19.5 12.7 22.7 17.9 19.5 21.7 18.5 21.4 26.5 18.9 18.4 20.1 17.2 21.8 14.3 26.9 18.9 18.7 22.7 22.0 19.0 21.2 55.2 23.8 19.5 21.3 18.9 20.9 20.6 15.6 18.8 41.0 19.8 42.6 32.2 24.7 20.6 19.8 71.0 70.0 70.0 77.5 49.7 38.7 79.5 59.2 54.6 84.1 74.5 113.9 49.8 83.0 53.4 54.6 62.3 50.6 135.7 62.5 105.8 83.9 86.4 103.4 39.1 100.6 49.0 127.4 67.5 27.9 49.3 65.1 57.8 39.3 68.1 85.3 129.8 47.2 62.8 81.4 125.2 94.8 92.8 84.9 64.2 114.1 150.0 63.1 45.0 53.8 65.1 53.7 36.4 58.9 51.4 56.7 39.5 60.5 43.9 51.7 65.0 62.7 97.2 42.0 83.0 87.7 44.9 130.5 63.6 51.1 35.8 44.5 40.2 42.4 46.6 34.7 41.8 41.7 40.6 37.0 40.4 37.0 23.1 40.4 41.6 32.0 53.4 43.6 18.1 18.7 19.0 20.6 17.9 19.5 18.9 18.4 18.9 18.9 18.8 19.8 18.4 19.2 25.2 19.9 17.5 20.5 16.7 17.9 22.2 8.5 14.1 14.0 17.3 11.5 19.9 12.9 8.4 54.1 17.8 14.8 21.5 21.1 26.1 9.8 15.4 17.1 12.1 18.3 13.9 18.8 31.8 17.1 9.7 11.7 17.1 16.3 17.5 14.2 25.6 5.0 18.2 13.4 24.4 11.9 14.7 13.0 19.3 17.6 19.6 17.8 26.4 15.3 12.3 16.1 33.1 19.2 8.5 18.8 14.0 16.0 11.2 14.6 15.6 11.6 0.0 13.0 17.7 19.5 17.1 15.5 16.2 35.7 21.3 12.7 15.7 16.3 USP4 "UNP, Unph" ENSG00000114316 "Ubiquitin specific peptidase 4" Q13107 3 49277144-49340712 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 131.8;Late spermatids: 104.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA018499 Approved Approved "Plasma membrane,Cytosol" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 30: Epithelial cell lines - Translation" "Cluster 34: Spermatids - Unknown function" "Plasma membrane, Cytosol" "HPA018499: AB_1858689" "unprognostic (2.34e-3)" "unprognostic (1.52e-1)" "unprognostic (2.22e-3)" "unprognostic (6.12e-2)" "unprognostic (3.51e-1)" "unprognostic (4.33e-2)" "unprognostic (9.42e-2)" "prognostic favorable (4.46e-5)" "unprognostic (3.54e-1)" "unprognostic (9.07e-3)" "unprognostic (2.78e-2)" "unprognostic (1.70e-3)" "prognostic favorable (4.29e-5)" "unprognostic (7.30e-2)" "unprognostic (1.00e-1)" "unprognostic (1.18e-2)" "unprognostic (1.65e-2)" 25.2 20.3 24.2 26.5 26.3 53.7 24.9 24.5 28.2 27.7 27.1 25.4 18.3 24.4 21.6 26.0 22.4 18.3 26.5 23.7 23.4 21.8 20.2 29.5 30.9 23.9 24.4 24.5 19.0 24.1 16.4 23.3 23.9 23.7 23.4 26.9 21.0 21.7 31.6 31.4 22.5 24.0 22.4 33.7 20.2 28.0 24.8 37.0 23.0 28.8 33.7 25.8 25.0 24.5 14.2 15.8 21.6 28.8 38.7 40.1 14.7 36.4 32.9 46.7 41.3 16.8 34.8 27.1 14.4 53.9 27.4 18.9 28.6 52.6 42.5 42.1 8.4 60.3 31.9 19.6 57.0 32.5 34.0 42.8 23.3 51.0 41.5 34.3 55.0 29.9 21.6 41.6 42.1 24.5 38.3 55.8 18.7 17.7 26.9 15.6 13.3 23.9 37.5 29.2 17.5 24.0 27.2 19.3 14.0 21.6 13.5 51.2 50.1 31.1 17.2 39.6 22.5 33.6 17.3 38.6 28.6 50.1 36.5 70.1 83.6 94.8 48.1 69.2 53.7 51.0 50.2 48.9 74.6 41.4 47.7 42.2 179.2 72.4 81.2 28.4 59.7 78.0 24.2 26.3 24.5 28.2 23.7 23.4 23.9 24.4 23.9 22.4 24.8 24.5 24.3 41.7 25.1 28.1 24.7 18.7 17.9 17.2 22.2 17.5 10.9 10.3 17.9 10.0 23.2 20.2 20.9 22.7 27.9 13.6 21.5 16.5 131.8 17.3 18.3 22.1 10.7 31.6 30.8 13.6 14.3 17.9 27.5 21.1 33.6 21.4 17.5 14.6 24.0 11.8 26.4 13.8 16.2 38.6 21.0 104.9 15.5 34.2 16.0 16.9 36.0 13.9 23.7 25.6 20.2 18.9 7.6 19.2 29.2 17.6 14.5 13.4 28.6 20.5 13.1 18.4 17.0 35.3 14.5 17.9 18.5 24.2 29.4 17.0 13.9 14.5 USP40 FLJ10785 ENSG00000085982 "Ubiquitin specific peptidase 40" Q9NVE5 2 233475520-233566782 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 79.3;Oligodendrocytes: 127.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005821 Uncertain Approved "Vesicles,Focal adhesion sites" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 68: Epididymis - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 64: Astrocytes - Nervous system maintenance" Vesicles "Focal adhesion sites" "HPA005821: AB_1080526" "unprognostic (2.19e-1)" "unprognostic (1.04e-1)" "unprognostic (1.13e-1)" "unprognostic (1.33e-1)" "unprognostic (3.70e-1)" "unprognostic (2.15e-1)" "unprognostic (5.30e-2)" "unprognostic (2.25e-1)" "unprognostic (1.80e-2)" "unprognostic (1.18e-1)" "unprognostic (1.96e-1)" "unprognostic (1.26e-1)" "unprognostic (2.22e-1)" "unprognostic (1.45e-1)" "unprognostic (4.09e-2)" "unprognostic (1.90e-2)" "unprognostic (2.53e-2)" 11.8 12.0 10.4 7.5 17.0 3.4 13.9 12.8 11.4 10.0 16.5 9.4 10.5 10.6 24.0 10.4 11.5 11.6 8.2 10.2 12.0 14.2 13.2 12.5 7.2 19.4 14.2 15.9 14.0 16.8 8.5 12.4 19.0 13.5 9.5 14.2 12.9 10.4 9.6 19.7 10.1 8.5 12.3 9.9 13.1 14.7 16.2 10.1 16.4 7.6 7.8 9.6 7.5 25.4 17.3 19.9 17.6 12.0 25.2 23.0 15.7 16.4 12.4 14.7 16.0 14.3 20.2 0.4 4.7 26.4 38.6 30.3 13.3 29.7 20.6 0.0 9.0 13.3 17.4 24.3 22.3 5.8 8.9 22.2 21.1 22.2 30.9 26.2 17.3 8.1 22.0 3.2 21.4 14.0 6.2 8.5 7.9 17.8 16.0 0.0 36.3 8.1 17.9 27.6 9.6 10.3 13.5 13.5 16.9 12.9 15.4 12.9 17.3 20.9 13.1 8.9 20.6 6.0 4.9 0.8 27.1 10.2 18.6 0.0 1.0 0.0 0.5 1.1 0.2 0.4 0.5 0.4 1.5 0.7 0.7 0.7 0.1 0.5 0.9 1.9 0.8 0.5 10.4 17.0 12.8 11.4 10.2 12.0 19.4 14.2 19.0 12.3 16.2 25.4 11.8 32.1 35.5 79.3 7.9 7.4 9.1 13.6 15.4 18.1 17.0 14.7 10.7 10.0 19.9 16.5 25.0 21.2 6.7 9.9 7.9 9.4 8.4 19.8 18.3 11.1 15.0 5.7 25.9 12.6 10.6 11.9 21.4 21.3 9.5 23.4 12.8 25.4 8.2 23.5 38.2 10.9 4.1 11.6 3.6 10.7 6.8 9.1 3.6 40.3 5.9 11.9 4.1 48.2 127.7 10.5 12.6 8.2 10.9 12.9 13.9 14.6 21.0 19.4 13.1 17.5 10.6 30.2 20.9 17.2 10.5 15.7 5.5 21.1 12.1 10.0 USP42 FLJ12697 ENSG00000106346 "Ubiquitin specific peptidase 42" Q9H9J4 7 6104884-6161564 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Differentiation, Spermatogenesis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 89.1;Spermatocytes: 72.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006939, HPA064800" Approved Nucleoplasm,Nucleoli NA NA "Cluster 10: Basophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 59: Non-specific - Transcription" Nucleoplasm Nucleoli "HPA006939: , HPA064800: AB_2685355" "unprognostic (1.48e-2)" "unprognostic (1.47e-1)" "unprognostic (2.59e-1)" "unprognostic (1.69e-1)" "unprognostic (1.30e-2)" "unprognostic (1.53e-1)" "unprognostic (1.19e-2)" "unprognostic (3.32e-1)" "unprognostic (1.05e-1)" "unprognostic (2.82e-1)" "unprognostic (6.21e-3)" "unprognostic (2.47e-2)" "unprognostic (3.17e-3)" "unprognostic (3.14e-2)" "unprognostic (3.06e-2)" "unprognostic (2.19e-2)" "unprognostic (2.66e-1)" 3.8 3.0 3.1 3.2 3.0 13.4 3.9 5.8 4.4 4.3 2.4 4.5 4.5 4.9 3.6 3.7 4.3 3.4 3.2 3.0 3.0 3.9 4.0 4.1 3.8 2.8 3.1 4.9 3.8 4.7 3.8 3.3 2.7 3.8 3.4 5.8 3.5 3.1 4.3 5.4 4.3 4.1 2.9 4.4 3.6 15.2 3.2 5.7 4.0 3.4 3.2 4.0 3.8 3.2 10.2 7.4 13.1 12.9 7.4 5.5 9.0 5.4 6.9 6.2 6.1 5.3 5.2 12.0 3.4 6.7 9.2 9.3 11.1 5.9 6.7 2.9 8.6 5.6 6.1 5.5 6.3 13.0 6.1 6.4 6.8 6.7 8.5 5.7 7.7 10.0 21.7 7.9 4.1 9.1 7.9 14.6 14.8 5.2 5.6 14.9 10.2 8.2 5.9 5.3 10.0 17.7 6.9 14.0 4.3 12.0 6.5 6.6 6.5 5.5 20.5 7.0 6.5 7.0 6.3 10.3 4.6 7.8 11.0 0.6 0.3 0.9 0.5 0.6 0.7 0.4 0.6 0.3 0.3 0.2 0.4 1.0 0.3 0.5 0.3 0.6 0.5 0.2 3.1 3.0 5.8 4.4 3.0 3.0 2.8 3.1 2.7 2.9 3.2 3.2 13.7 12.8 7.0 19.6 16.1 40.5 18.2 5.2 26.7 18.7 17.4 10.8 10.5 8.6 6.8 1.8 22.9 8.3 16.4 20.7 0.0 10.4 89.1 27.1 15.3 14.4 10.7 10.8 26.1 10.4 8.4 13.4 15.3 25.6 9.5 13.4 12.8 9.8 8.2 21.9 26.2 18.1 8.2 9.1 19.9 42.5 14.3 12.4 10.6 18.7 7.7 10.1 12.3 18.6 26.2 12.0 7.7 12.8 21.7 22.3 12.4 5.7 10.6 18.7 13.1 16.2 14.9 72.4 37.0 23.1 41.5 26.8 19.2 6.4 14.4 15.3 USP43 FLJ30626 ENSG00000154914 "Ubiquitin specific peptidase 43" Q70EL4 17 9644698-9729687 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 37.9;Excitatory neurons: 35.5;Glandular and luminal cells: 52.5;Oligodendrocyte precursor cells: 73.4;Syncytiotrophoblasts: 73.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 11.7;SK-BR-3: 8.1;T-47d: 9.9" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" "HPA023389, HPA027762, HPA027763" Uncertain Approved "Nucleoplasm,Nuclear speckles" NA NA "Cluster 29: Non-specific - Vesicular transport" "Cluster 28: BEWO - Transcription regulation" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Nuclear speckles" "HPA023389: AB_1858691, HPA027762: AB_10603001, HPA027763: " "unprognostic (1.39e-1)" "unprognostic (1.75e-2)" "unprognostic (1.07e-1)" "unprognostic (2.30e-3)" "unprognostic (1.08e-1)" "unprognostic (5.24e-2)" "unprognostic (2.04e-1)" "unprognostic (6.40e-3)" "unprognostic (2.26e-1)" "unprognostic (3.05e-3)" "unprognostic (2.41e-2)" "unprognostic (7.49e-2)" "unprognostic (5.95e-2)" "prognostic favorable (5.39e-4)" "unprognostic (3.24e-1)" "unprognostic (2.06e-1)" "unprognostic (3.28e-1)" 0.3 0.2 2.6 0.6 3.4 0.7 1.9 0.8 4.1 2.9 2.9 3.5 4.2 1.9 1.0 6.5 4.2 1.2 0.0 3.3 1.4 4.0 9.1 3.2 0.1 2.5 4.6 0.1 5.0 1.1 3.5 8.3 2.5 9.8 3.2 1.4 4.3 2.2 0.0 2.2 3.5 0.2 2.1 0.3 2.1 3.2 2.3 0.3 1.7 0.0 0.7 1.1 2.4 2.5 5.6 1.4 0.0 0.5 0.0 0.0 11.7 0.1 0.2 0.6 1.6 2.8 4.5 0.0 1.8 0.2 2.5 6.8 0.6 5.3 0.6 3.6 1.8 0.3 3.0 1.0 0.1 0.5 0.0 0.0 6.8 0.3 2.8 0.3 0.0 0.8 0.0 0.0 0.0 2.6 0.9 4.6 0.7 4.8 0.3 3.6 0.0 0.8 4.1 3.0 0.7 0.0 2.4 8.1 1.0 3.7 9.9 1.4 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.7 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.6 3.4 0.8 4.1 3.3 1.4 2.5 4.6 2.5 2.1 2.3 2.5 0.0 3.2 3.1 1.6 0.3 4.7 7.8 4.6 5.2 0.5 7.0 2.4 0.6 4.3 7.4 11.0 6.2 26.2 0.6 14.3 1.9 4.4 1.1 37.9 4.2 0.5 2.4 3.2 35.5 4.7 23.7 0.8 7.7 52.5 0.0 0.9 0.4 15.6 2.7 0.0 4.0 8.3 2.0 0.9 0.3 1.1 0.0 0.6 5.4 0.0 0.3 8.4 0.0 73.4 1.2 11.3 3.5 0.0 0.2 10.6 8.7 1.8 30.2 1.5 0.0 0.0 1.0 1.5 0.3 12.3 3.3 73.2 0.7 0.0 9.7 11.8 USP44 FLJ14528 ENSG00000136014 "Ubiquitin specific peptidase 44" Q9H0E7 12 95516560-95551476 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 7.1;testis: 24.2" "Cell type enriched" "Detected in many" 4 "Early spermatids: 482.2" "Cancer enhanced" "Detected in some" "testis cancer: 3.0" "Region enriched" "Detected in many" 6 "cerebellum: 7.1" "Immune cell enhanced" "Detected in many" "naive CD4 T-cell: 6.1" "Group enriched" "Detected in many" 41 "B-cells: 4.6;T-cells: 6.1" "Cell line enhanced" "Detected in some" "HEL: 26.4;JURKAT: 58.4;NTERA-2: 138.3" "Not detected" "Not detected" "Low region specificity" "Detected in single" HPA026543 Approved "Nucleoli fibrillar center,Microtubules" NA NA "Cluster 30: Non-specific - Translation" "Cluster 78: Testis - Spermatogenesis" "Cluster 5: NTERA-2 - Transcription" "Cluster 23: Spermatids - Flagellum & Golgi organization" "Nucleoli fibrillar center, Microtubules" "HPA026543: AB_1858692" "unprognostic (2.12e-2)" "unprognostic (1.14e-1)" "unprognostic (4.68e-2)" "unprognostic (1.01e-3)" "unprognostic (1.83e-4)" "unprognostic (7.18e-4)" "unprognostic (5.55e-2)" "unprognostic (1.85e-2)" "unprognostic (2.16e-1)" "unprognostic (3.73e-2)" "unprognostic (6.88e-2)" "unprognostic (2.97e-2)" "unprognostic (8.12e-2)" "unprognostic (1.41e-2)" "unprognostic (1.08e-1)" "unprognostic (7.41e-2)" "unprognostic (7.07e-2)" 0.7 0.6 0.6 1.0 0.8 0.3 0.9 7.1 1.0 0.9 0.0 1.2 0.3 1.3 0.7 0.4 1.2 0.8 0.5 0.6 0.5 1.4 0.1 3.9 1.1 0.8 0.9 0.9 2.3 1.7 1.3 0.1 1.0 0.7 0.4 1.7 1.1 1.6 0.2 0.3 0.8 0.9 0.7 1.5 0.6 24.2 0.5 3.6 1.3 0.3 1.2 0.5 0.5 1.2 0.2 0.4 11.4 0.0 0.1 0.1 0.4 1.1 3.3 1.4 0.5 0.0 0.1 0.1 3.4 0.0 0.0 0.1 0.0 0.0 1.9 0.0 5.8 26.4 0.0 0.0 5.8 10.8 0.5 0.1 0.0 0.8 0.0 0.6 0.6 58.4 4.3 0.0 0.0 0.0 13.9 0.1 138.3 0.0 0.0 0.0 0.0 0.0 2.4 0.8 8.8 5.9 0.0 0.0 0.1 13.2 0.1 0.9 0.0 0.1 0.0 0.0 0.0 0.0 0.3 4.6 0.0 1.0 0.3 0.0 0.0 0.0 1.1 0.0 2.4 4.6 1.7 1.5 0.0 3.7 6.1 4.0 0.1 0.1 0.0 0.0 0.2 1.0 0.6 0.8 7.1 1.0 0.6 0.5 0.8 0.9 1.0 0.7 0.5 1.2 1.9 12.8 31.0 1.3 5.7 1.0 3.4 0.3 4.6 8.6 1.5 3.2 1.8 0.0 3.8 7.3 6.2 2.8 0.6 0.1 0.0 4.4 482.2 0.9 2.2 2.5 0.0 0.4 5.1 3.1 0.5 3.5 1.1 1.8 0.0 10.6 1.8 0.0 0.1 0.0 16.2 0.0 0.0 0.3 1.0 116.6 5.6 0.8 3.6 1.9 0.6 2.4 1.0 15.6 4.0 0.9 0.1 3.4 1.1 5.0 0.1 1.0 0.3 9.5 6.6 2.9 3.7 77.6 6.7 0.6 0.9 1.1 3.2 2.5 0.1 1.9 USP45 MGC14793 ENSG00000123552 "Ubiquitin specific peptidase 45" Q70EL2 6 99432325-99521728 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease variant, Leber congenital amaurosis" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 7 "brain: 53.5" "Cell type enhanced" "Detected in many" "Excitatory neurons: 47.1;Inhibitory neurons: 44.4;Oligodendrocytes: 39.4" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in all" 6 "cerebellum: 53.5" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029602, HPA029604" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 1: K-562 - Erythropoiesis" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoplasm, Cytosol" "HPA029602: AB_10600418, HPA029604: AB_10602283" "unprognostic (7.81e-3)" "unprognostic (3.10e-3)" "unprognostic (1.63e-2)" "unprognostic (6.62e-2)" "unprognostic (1.02e-2)" "unprognostic (1.92e-1)" "unprognostic (2.15e-2)" "unprognostic (1.01e-1)" "unprognostic (2.77e-2)" "unprognostic (8.65e-2)" "unprognostic (2.95e-3)" "unprognostic (1.10e-1)" "unprognostic (3.43e-3)" "unprognostic (1.13e-1)" "unprognostic (3.53e-1)" "unprognostic (1.43e-1)" "unprognostic (6.91e-2)" 6.1 4.4 5.2 4.9 5.8 4.4 4.6 53.5 9.4 4.3 3.8 5.3 7.3 5.1 4.8 5.3 4.0 6.2 6.2 5.8 6.3 6.3 4.2 3.7 7.4 6.0 7.7 4.5 4.0 4.5 3.6 5.2 8.2 5.1 6.7 6.7 4.0 4.2 6.0 6.3 5.8 4.5 5.3 4.6 4.4 3.3 6.2 3.1 5.3 5.5 5.2 4.3 3.8 9.0 5.9 4.0 8.1 11.2 14.3 13.5 8.7 10.3 11.1 10.1 14.7 8.2 6.4 15.2 7.3 10.3 11.9 7.7 12.1 9.8 13.9 12.2 12.0 15.2 8.4 6.7 11.4 14.2 8.3 15.3 7.6 9.2 15.5 10.7 15.4 13.8 37.2 14.8 9.6 5.5 4.5 13.3 12.8 9.1 8.9 6.8 5.9 8.9 13.8 6.8 11.3 9.2 7.0 9.1 7.8 10.0 4.9 6.8 15.5 5.5 7.1 8.1 15.5 6.3 6.2 29.1 9.8 13.1 10.1 2.9 1.4 0.4 3.2 0.8 4.2 5.3 2.7 4.0 2.4 6.7 1.9 1.9 0.3 1.9 2.0 3.6 2.6 1.0 5.2 5.8 53.5 9.4 5.8 6.3 6.0 7.7 8.2 5.3 6.2 9.0 13.3 3.2 5.8 22.5 13.3 2.3 9.6 6.8 4.6 10.3 4.4 4.6 9.4 4.3 4.7 3.7 18.8 6.4 7.3 5.9 5.9 4.3 15.7 10.1 10.3 7.6 2.4 4.2 47.1 2.5 6.6 7.1 9.7 4.3 2.5 5.8 6.8 4.5 4.0 10.1 44.4 2.9 10.2 4.8 2.6 10.2 13.1 4.6 3.6 22.5 10.0 5.4 2.1 32.6 39.4 5.0 3.1 8.6 6.5 8.6 8.3 15.8 10.4 7.4 0.0 6.3 6.7 1.9 7.5 5.2 2.8 7.4 7.1 5.8 7.3 6.9 USP46 FLJ12552 ENSG00000109189 "Ubiquitin specific peptidase 46" P62068 4 52590960-52659301 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Behavior, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 4 "Bipolar cells: 150.8;Early spermatids: 229.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007288, CAB076369, CAB076370" Uncertain Approved "Nucleoli,Nucleoli rim" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 39: Non-specific - Mitochondria" "Cluster 12: NES - Nervous system development" "Cluster 29: Early spermatids - Spermatogenesis" "Nucleoli, Nucleoli rim" "CAB076369: AB_2665642, CAB076370: AB_2665643, HPA007288: AB_1080531" "unprognostic (1.15e-2)" "unprognostic (1.64e-1)" "unprognostic (1.19e-1)" "unprognostic (1.61e-2)" "unprognostic (1.31e-1)" "unprognostic (1.41e-1)" "unprognostic (1.53e-3)" "unprognostic (1.59e-1)" "unprognostic (2.45e-2)" "unprognostic (1.80e-2)" "unprognostic (2.89e-1)" "unprognostic (1.95e-1)" "unprognostic (1.05e-1)" "unprognostic (1.45e-1)" "unprognostic (3.95e-2)" "unprognostic (2.02e-2)" "unprognostic (1.28e-1)" 4.4 8.6 30.4 3.3 31.2 2.9 6.4 27.4 31.5 7.6 22.4 3.9 4.4 6.5 5.4 11.5 7.0 5.3 28.6 30.8 33.3 9.9 2.9 3.9 3.7 27.9 33.9 11.0 5.2 10.4 4.6 5.3 26.7 6.9 4.0 11.5 8.3 6.7 14.5 7.5 4.2 5.0 30.4 3.3 6.0 12.3 32.5 3.4 9.3 12.5 5.5 6.0 7.4 26.8 8.1 5.7 18.0 13.3 19.1 23.8 19.8 13.0 10.5 9.5 7.9 11.5 6.2 5.4 14.9 13.0 13.4 4.7 31.6 15.1 17.2 4.7 11.1 8.4 5.3 12.8 19.1 11.2 9.4 20.4 13.9 9.7 9.1 18.4 14.2 7.4 8.3 7.4 20.3 7.4 4.8 5.9 13.3 9.0 6.8 12.0 13.1 1.1 20.3 14.8 10.8 12.9 6.4 21.5 12.9 17.1 7.9 8.2 13.3 9.2 20.1 10.9 19.9 7.5 3.7 4.2 14.2 6.7 11.6 0.7 0.4 0.1 0.7 0.4 0.5 0.4 1.2 0.6 0.9 0.4 0.2 0.2 0.1 0.4 0.3 1.4 0.4 0.3 30.4 31.2 27.4 31.5 30.8 33.3 27.9 33.9 26.7 30.4 32.5 26.8 10.0 6.4 7.2 24.2 6.4 5.4 11.2 15.2 26.2 150.8 13.7 11.7 44.9 14.3 16.4 14.7 4.2 12.1 10.7 5.2 21.5 10.8 229.8 18.4 34.9 12.5 4.2 6.7 32.6 12.0 12.5 17.8 17.3 15.6 0.0 22.9 13.6 6.8 5.8 35.3 24.3 5.9 10.2 8.4 4.6 34.1 28.9 7.9 8.8 21.5 12.9 30.0 5.2 30.2 12.6 12.5 9.9 36.1 9.5 21.1 3.9 17.1 23.8 8.7 6.6 16.2 15.9 3.2 14.4 25.9 8.2 7.7 8.0 18.3 7.1 17.7 USP47 ENSG00000170242 "Ubiquitin specific peptidase 47" Q96K76 11 11841423-11961887 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 315.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029286, HPA029289" Supported Approved "Vesicles,Intermediate filaments" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 54: Cardiomyocytes - Muscle contraction" "Intermediate filaments" Vesicles "HPA029286: AB_10599852, HPA029289: AB_10601675" "unprognostic (2.02e-1)" "unprognostic (2.72e-1)" "unprognostic (3.05e-1)" "unprognostic (1.84e-1)" "unprognostic (2.99e-2)" "unprognostic (2.65e-2)" "unprognostic (2.27e-2)" "unprognostic (7.39e-2)" "unprognostic (1.54e-2)" "unprognostic (7.05e-2)" "unprognostic (2.83e-2)" "unprognostic (2.35e-1)" "unprognostic (1.51e-1)" "unprognostic (9.96e-3)" "unprognostic (1.90e-1)" "unprognostic (1.49e-1)" "unprognostic (2.85e-1)" 15.7 14.3 11.9 11.4 15.8 19.0 15.1 17.3 12.8 14.3 10.2 19.8 10.3 17.2 15.6 16.1 13.5 12.3 23.5 12.5 14.1 13.2 23.3 16.2 13.3 14.1 12.8 15.9 16.9 22.2 13.8 16.7 15.0 16.6 12.3 25.7 14.1 15.4 59.8 18.0 14.1 17.8 14.1 11.8 16.6 15.0 12.7 19.1 14.9 33.6 13.8 16.7 14.2 20.6 26.8 15.7 30.3 13.1 21.8 23.2 12.6 31.6 22.3 20.1 22.1 16.5 22.2 29.6 13.3 28.0 23.7 17.8 23.7 15.3 30.3 27.5 20.4 18.6 30.3 12.6 21.5 25.0 23.9 22.3 22.5 12.3 29.0 26.1 21.8 21.7 35.8 23.7 25.4 10.6 21.7 14.3 7.9 28.1 12.7 21.4 30.3 9.4 24.6 29.1 9.8 21.0 25.8 19.6 19.3 18.4 14.4 20.6 24.9 27.8 16.2 22.3 19.6 7.9 18.1 25.9 19.9 15.2 20.3 14.7 5.9 11.9 11.0 7.4 14.5 7.4 10.3 11.4 7.9 6.7 13.1 11.4 2.8 18.5 11.5 4.8 8.3 7.9 11.9 15.8 17.3 12.8 12.5 14.1 14.1 12.8 15.0 14.1 12.7 20.6 41.1 70.5 63.1 116.5 46.9 71.0 68.8 28.8 45.5 67.5 41.1 30.9 222.5 40.0 56.0 23.9 47.9 69.6 57.2 30.4 25.4 39.5 40.1 49.8 63.0 44.8 59.3 34.3 122.7 38.9 33.2 69.7 44.4 134.5 54.3 52.6 32.5 53.9 28.0 63.9 136.5 32.9 24.4 27.7 39.7 30.0 44.1 41.8 24.9 96.5 40.5 79.7 68.0 171.4 315.9 44.8 31.5 50.0 55.2 65.5 29.7 21.9 48.2 52.4 52.6 85.0 68.2 92.8 55.1 46.6 87.9 125.7 65.0 41.8 35.0 58.9 USP48 "FLJ11328, FLJ20103, FLJ23054, FLJ23277, MGC14879, USP31" ENSG00000090686 "Ubiquitin specific peptidase 48" Q86UV5 1 21678298-21783606 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Granulosa cells: 200.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030045, HPA030046" Approved Supported Nucleoplasm,Mitochondria,Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 2: Karpas-707 - Immune response" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "Mitochondria, Cytosol" "HPA030045: AB_10670833, HPA030046: AB_10603325" "unprognostic (1.35e-1)" "unprognostic (3.72e-1)" "unprognostic (5.46e-3)" "unprognostic (2.21e-1)" "unprognostic (1.23e-1)" "unprognostic (7.00e-3)" "prognostic unfavorable (6.09e-8)" "unprognostic (1.04e-2)" "unprognostic (3.01e-3)" "unprognostic (9.30e-2)" "unprognostic (7.54e-2)" "unprognostic (4.45e-2)" "unprognostic (4.16e-3)" "unprognostic (2.03e-1)" "unprognostic (1.06e-1)" "unprognostic (5.70e-2)" "unprognostic (2.80e-2)" 25.8 47.5 18.7 26.6 24.5 43.5 26.4 31.0 26.4 26.9 21.6 24.4 21.7 25.3 20.4 23.0 22.3 18.9 21.6 19.3 20.4 18.2 23.8 23.1 35.1 20.1 20.4 31.1 24.6 25.2 26.9 27.3 21.7 23.5 26.0 57.0 31.2 18.6 23.1 29.5 28.7 22.9 18.5 36.0 32.5 20.6 20.8 26.9 28.6 19.5 34.5 23.1 24.6 36.0 43.9 20.5 47.0 34.0 40.1 49.0 46.4 54.0 36.5 35.3 46.6 19.1 43.2 49.1 35.6 48.8 27.5 39.2 59.0 43.4 53.6 48.3 42.1 104.3 75.7 34.5 35.5 53.0 53.7 39.8 36.6 36.1 39.7 48.1 106.1 36.2 83.8 133.2 44.0 21.9 44.2 68.5 29.7 44.5 36.8 61.3 47.2 57.3 40.7 36.2 57.1 35.6 50.4 45.7 122.7 62.3 23.4 63.0 76.1 37.7 30.9 46.7 31.8 105.6 81.7 48.1 36.3 64.5 56.6 82.1 19.5 35.0 12.2 9.4 13.9 28.6 17.8 17.9 21.1 29.8 20.5 13.1 16.8 12.2 10.9 15.3 21.4 12.6 18.7 24.5 31.0 26.4 19.3 20.4 20.1 20.4 21.7 18.5 20.8 36.0 37.9 54.5 42.1 32.0 55.4 22.2 25.1 30.3 33.0 86.5 22.2 24.5 65.3 21.5 24.4 20.2 62.6 61.4 48.3 17.8 25.4 28.5 71.4 33.3 48.5 32.5 21.7 88.1 66.4 20.0 56.3 42.0 33.1 41.4 49.9 200.4 27.5 22.1 29.2 50.5 74.2 31.3 32.6 22.6 28.1 47.7 34.8 34.4 58.7 52.5 55.9 30.7 36.0 54.3 112.3 23.8 16.4 51.6 150.1 20.7 24.1 20.2 27.3 69.2 32.9 51.7 39.8 52.7 47.4 35.1 25.7 32.6 41.8 54.8 31.6 21.6 USP49 MGC20741 ENSG00000164663 "Ubiquitin specific peptidase 49" Q70CQ1 6 41789896-41895361 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "mRNA processing, mRNA splicing, Ubl conjugation pathway" "Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 43.8;Excitatory neurons: 42.8;Inhibitory neurons: 48.6;Oligodendrocyte precursor cells: 56.3;Oligodendrocytes: 31.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in some" 5 "basophil: 5.1" "Lineage enriched" "Detected in single" 8 "granulocytes: 5.1" "Cell line enhanced" "Detected in all" "REH: 46.7;U-698: 63.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030254, HPA030255" Uncertain NA NA "Cluster 10: Basophils - Unknown function" "Cluster 6: Brain - Smell perception" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 56: Bipolar cells - Visual perception" "HPA030254: AB_10600198, HPA030255: AB_10601218" "unprognostic (1.71e-1)" "unprognostic (4.86e-3)" "unprognostic (1.93e-1)" "unprognostic (2.57e-4)" "unprognostic (4.46e-2)" "unprognostic (2.84e-4)" "unprognostic (7.17e-3)" "unprognostic (5.06e-2)" "unprognostic (1.19e-2)" "unprognostic (3.22e-1)" "unprognostic (5.59e-3)" "unprognostic (8.28e-2)" "unprognostic (1.26e-5)" "unprognostic (5.39e-2)" "unprognostic (4.58e-2)" "unprognostic (4.37e-3)" "unprognostic (3.24e-3)" 2.9 2.8 4.3 2.6 3.2 5.3 2.6 6.0 3.8 3.4 0.4 2.6 1.7 2.9 1.6 1.9 2.6 1.6 2.0 3.3 3.7 2.0 1.6 2.7 2.6 2.7 3.9 3.1 2.0 1.5 2.7 1.4 2.5 2.3 1.5 9.3 2.0 1.6 2.9 3.0 1.7 1.6 0.7 2.5 1.8 4.8 4.1 6.7 7.0 1.0 2.5 2.5 2.6 3.8 6.0 1.8 23.6 11.6 2.8 3.0 9.7 2.3 2.2 3.4 4.3 7.5 1.4 24.5 2.5 2.9 4.9 2.6 14.7 2.2 5.1 6.1 11.0 8.8 10.3 2.7 2.0 6.9 5.2 3.1 1.7 5.0 3.1 3.1 2.2 24.9 18.7 6.4 2.6 3.5 26.7 10.5 6.5 6.4 2.2 46.7 11.3 5.4 1.4 4.1 15.8 6.5 3.1 1.1 1.3 5.5 3.5 6.1 6.1 8.1 8.0 2.6 3.1 12.2 11.4 63.9 1.0 6.9 1.5 5.1 0.4 0.6 0.3 0.4 0.2 0.6 0.2 0.3 0.1 0.4 0.4 0.3 1.0 0.4 0.5 0.3 0.2 0.2 4.3 3.2 6.0 3.8 3.3 3.7 2.7 3.9 2.5 0.7 4.1 3.8 2.4 0.0 9.7 20.2 2.0 5.0 3.0 3.9 1.2 27.5 3.6 3.3 4.6 4.3 6.5 5.5 43.8 2.9 4.5 1.4 1.9 1.9 6.5 4.1 5.0 2.8 0.0 8.2 42.8 2.0 1.6 4.3 3.1 4.6 1.3 4.8 1.4 2.1 2.0 15.2 48.6 1.9 4.1 3.1 4.6 7.2 3.7 3.1 3.6 14.0 5.0 2.8 2.1 56.3 31.8 2.6 1.9 6.0 3.0 4.5 2.1 1.1 7.1 10.9 6.6 6.2 3.4 13.3 14.3 2.7 6.3 5.7 2.4 5.1 2.2 4.6 USP5 IsoT ENSG00000111667 "Ubiquitin specific peptidase 5" P45974 12 6852148-6866632 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006756 Uncertain Approved Nucleoplasm,Cytosol NA NA 1200000 "Cluster 27: Non-specific - Gene expression" "Cluster 59: Non-specific - Translation" "Cluster 5: NTERA-2 - Transcription" "Cluster 66: Spermatocytes - Spermatogenesis" "Nucleoplasm, Cytosol" "HPA006756: AB_1080534" "unprognostic (2.19e-1)" "unprognostic (5.83e-2)" "unprognostic (2.48e-1)" "unprognostic (2.57e-1)" "unprognostic (7.60e-2)" "unprognostic (2.21e-2)" "unprognostic (4.02e-2)" "unprognostic (3.93e-2)" "unprognostic (2.57e-1)" "unprognostic (4.71e-2)" "unprognostic (8.90e-3)" "unprognostic (4.69e-2)" "unprognostic (1.17e-2)" "unprognostic (2.65e-2)" "unprognostic (3.56e-1)" "unprognostic (3.23e-1)" "unprognostic (2.02e-3)" 27.1 37.9 23.7 26.7 26.1 22.8 19.5 15.5 38.0 24.1 2.4 31.3 25.3 31.5 17.4 38.2 25.9 18.5 33.0 25.3 33.6 20.1 23.1 20.5 29.2 31.0 31.3 19.4 17.8 41.4 27.8 25.4 38.8 26.5 22.2 15.7 20.0 29.6 66.7 48.1 26.1 35.5 15.0 21.2 22.9 40.9 28.9 36.5 26.7 42.5 29.4 29.8 24.2 29.0 88.1 135.7 88.4 100.4 59.0 53.9 113.4 93.0 70.9 109.2 78.8 129.4 84.9 105.7 47.6 98.5 86.5 75.2 98.6 92.7 69.5 198.6 84.0 97.1 105.5 71.0 45.8 88.5 97.2 55.6 52.9 94.8 64.9 72.9 94.8 41.7 85.4 40.9 91.1 97.4 132.9 44.4 172.8 89.3 56.5 103.4 115.5 73.5 62.9 84.5 48.5 97.4 63.5 96.3 41.1 110.6 38.3 72.4 92.4 91.5 109.1 70.4 117.6 49.0 124.5 163.8 102.1 55.3 91.3 5.4 19.3 8.3 24.3 25.1 23.1 15.0 21.7 20.8 28.4 13.9 20.1 20.9 1.3 17.6 24.4 20.5 19.9 27.7 23.7 26.1 15.5 38.0 25.3 33.6 31.0 31.3 38.8 15.0 28.9 29.0 11.3 9.6 13.1 7.5 14.0 11.6 11.4 18.0 8.6 18.7 13.1 10.8 9.5 17.2 11.5 22.0 60.5 45.9 14.8 21.5 11.7 28.1 14.7 10.6 14.7 15.3 16.7 19.4 11.5 20.5 30.7 16.6 10.2 13.7 14.7 29.6 11.4 22.2 28.4 40.4 11.9 19.3 14.2 13.0 7.4 19.2 23.0 10.9 16.0 9.4 32.4 16.0 13.4 6.0 11.9 20.2 17.4 33.8 14.1 10.3 22.5 18.5 7.9 16.2 32.9 13.3 17.2 51.7 25.6 17.6 15.5 52.8 15.4 27.6 27.5 7.9 USP50 ENSG00000170236 "Ubiquitin specific peptidase 50" Q70EL3 15 50494018-50546708 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in single" "testis: 1.6" "Group enriched" "Detected in some" 8 "Early spermatids: 107.8;Late spermatids: 58.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA039470 Uncertain NA NA "Cluster 71: Testis - DNA repair" "Cluster 23: Spermatids - Flagellum & Golgi organization" "HPA039470: AB_10672964" "unprognostic (7.05e-3)" "unprognostic (2.38e-1)" "unprognostic (2.01e-2)" "unprognostic (4.04e-3)" "unprognostic (3.37e-1)" "unprognostic (2.53e-2)" "unprognostic (3.95e-2)" "unprognostic (1.73e-2)" "unprognostic (1.51e-1)" "unprognostic (1.42e-1)" "unprognostic (1.85e-1)" "unprognostic (3.81e-2)" "unprognostic (4.65e-2)" "unprognostic (2.47e-1)" "unprognostic (7.49e-4)" "unprognostic (3.03e-1)" 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.3 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.6 0.3 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.3 0.0 1.6 0.1 0.0 0.2 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.3 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 107.8 0.1 0.2 0.1 0.0 0.0 2.6 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.4 0.2 0.1 0.0 3.2 0.0 0.0 0.0 0.0 58.0 0.3 0.2 0.0 2.8 0.0 0.0 0.0 3.0 9.5 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.6 0.1 3.8 0.4 0.0 0.0 0.1 0.1 0.1 0.0 0.1 USP51 ENSG00000247746 "Ubiquitin specific peptidase 51" Q70EK9 X 55484616-55489202 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "epididymis: 51.7" "Cell type enhanced" "Detected in many" "Bipolar cells: 23.7;Muller glia cells: 32.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "SuSa: 7.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA001942 Uncertain Approved "Nucleoli fibrillar center,Cytosol" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 68: Epididymis - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 5: Muller glia cells - Visual perception" Cytosol "Nucleoli fibrillar center" "HPA001942: AB_1080536" "unprognostic (1.19e-2)" "unprognostic (4.65e-2)" "unprognostic (3.67e-2)" "unprognostic (1.02e-3)" "unprognostic (8.08e-2)" "unprognostic (3.26e-1)" "unprognostic (3.17e-3)" "unprognostic (2.07e-3)" "unprognostic (5.69e-2)" "prognostic favorable (5.70e-4)" "unprognostic (1.01e-3)" "unprognostic (1.27e-1)" "prognostic favorable (2.63e-5)" "unprognostic (2.81e-3)" "unprognostic (5.92e-2)" "unprognostic (5.85e-2)" "unprognostic (1.63e-1)" 1.4 3.1 2.5 0.9 2.7 0.5 1.7 2.8 2.8 1.9 4.2 0.8 0.4 3.1 51.7 0.6 5.5 0.8 2.1 2.2 4.2 3.7 1.2 1.5 1.1 2.2 3.1 6.5 1.1 5.6 1.4 2.4 2.4 2.4 0.8 3.1 0.8 2.5 0.4 1.1 0.7 1.9 2.5 1.8 0.8 2.3 3.8 2.4 5.3 1.1 1.2 0.9 0.7 2.5 0.0 0.6 3.9 1.1 1.9 1.0 0.0 0.6 0.3 0.7 0.9 1.2 0.5 0.0 4.6 0.8 0.8 0.2 1.0 0.4 1.2 1.3 0.0 1.0 0.2 0.0 0.8 2.5 0.2 3.9 0.0 0.4 0.0 0.3 0.2 3.0 3.1 3.0 0.6 2.6 2.4 1.3 4.8 0.0 0.2 3.4 0.7 1.5 0.9 0.1 0.0 0.7 1.1 0.1 3.7 7.0 0.9 1.3 0.2 1.5 2.1 0.4 0.1 4.7 2.0 0.9 1.0 1.4 1.0 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.5 2.7 2.8 2.8 2.2 4.2 2.2 3.1 2.4 2.5 3.8 2.5 5.1 3.2 5.5 3.3 2.6 0.9 2.2 0.9 2.2 23.7 3.8 7.4 6.9 1.5 2.0 3.7 6.2 4.3 1.2 0.2 9.8 1.5 0.3 9.0 9.2 6.0 3.6 5.0 2.7 0.0 2.2 8.1 0.0 2.1 1.3 7.9 6.4 0.7 7.6 6.7 5.0 0.5 0.0 5.6 2.5 1.0 4.1 4.7 5.4 1.9 0.3 32.9 3.1 3.5 3.7 0.2 0.3 8.2 1.0 1.0 0.0 13.1 11.2 16.4 0.0 7.1 5.0 11.4 12.5 1.0 0.4 2.7 3.1 13.0 0.4 0.5 USP53 KIAA1350 ENSG00000145390 "Ubiquitin specific peptidase 53" Q70EK8 4 119212587-119295517 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Glandular and luminal cells: 586.8;Microglial cells: 269.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "BJ hTERT+: 327.9;SK-MEL-30: 102.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035844, HPA035845" Uncertain Approved "Plasma membrane,Cytosol" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 44: Endometrium - Transcription" "Plasma membrane, Cytosol" "HPA035844: AB_10669532, HPA035845: AB_2674817" "unprognostic (9.33e-2)" "unprognostic (1.49e-2)" "prognostic favorable (3.15e-6)" "unprognostic (4.37e-3)" "unprognostic (4.82e-2)" "unprognostic (5.03e-2)" "unprognostic (1.55e-1)" "unprognostic (9.54e-2)" "unprognostic (1.77e-1)" "unprognostic (9.81e-3)" "unprognostic (1.28e-1)" "prognostic unfavorable (7.54e-6)" "prognostic favorable (3.58e-8)" "unprognostic (9.02e-2)" "unprognostic (1.72e-1)" "unprognostic (1.58e-1)" "unprognostic (3.70e-2)" 37.8 14.4 5.6 5.7 5.8 0.9 25.3 6.1 6.2 18.5 11.8 16.3 5.7 13.1 13.1 17.0 30.6 10.2 24.0 4.9 7.3 19.9 7.3 29.4 12.4 9.4 8.1 9.4 24.6 8.1 10.3 10.5 7.3 9.2 16.1 3.4 12.7 11.5 33.5 11.7 9.7 10.2 6.5 7.2 15.1 7.8 8.6 5.4 10.5 51.7 8.0 12.7 12.0 5.5 11.4 6.8 2.4 0.0 60.5 60.4 13.6 70.6 327.9 6.2 8.1 7.4 10.4 46.1 2.5 21.1 12.1 5.5 5.5 5.3 16.1 6.1 4.5 3.1 5.2 2.6 47.2 3.9 0.7 20.3 15.0 21.9 31.0 11.7 29.8 3.0 7.3 1.7 8.4 2.5 2.9 5.2 6.7 7.0 3.8 0.9 11.4 9.2 16.4 7.2 3.8 3.0 3.9 27.5 102.4 13.3 7.0 2.7 32.3 2.0 7.0 26.3 6.4 3.3 5.2 7.8 31.4 1.7 7.9 1.3 0.0 0.0 0.4 0.0 0.5 0.7 1.0 0.8 0.1 0.7 1.9 1.0 0.2 0.9 0.0 0.3 0.9 0.3 5.6 5.8 6.1 6.2 4.9 7.3 9.4 8.1 7.3 6.5 8.6 5.5 27.6 35.3 44.5 80.6 18.5 61.8 73.6 21.2 48.3 17.8 74.1 46.6 99.0 32.9 33.9 119.5 29.2 48.4 15.1 207.8 45.0 33.4 5.6 167.2 45.9 35.7 34.6 4.8 32.4 62.7 17.3 86.0 41.8 586.8 70.8 19.8 23.9 30.5 9.3 25.2 32.5 80.4 52.9 21.3 76.4 7.3 19.0 36.5 14.2 269.8 45.6 25.0 12.3 11.6 11.9 110.6 214.5 10.9 18.6 138.6 46.0 20.1 27.3 31.5 6.6 91.8 32.9 18.0 4.0 62.6 42.3 49.8 26.8 14.8 62.6 124.8 USP54 "bA137L10.3, bA137L10.4, C10orf29, FLJ37318" ENSG00000166348 "Ubiquitin specific peptidase 54" Q70EL1 10 73497538-73625994 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 134.8" "Cell type enriched" "Detected in many" 4 "Oligodendrocytes: 476.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "OE19: 33.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA047663, HPA063665" Approved Approved Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 70: Brain - Nervous system development" "Cluster 21: OE19 - Mitochondria" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Mitochondria "HPA047663: AB_2680116, HPA063665: " "unprognostic (2.46e-2)" "unprognostic (1.67e-1)" "unprognostic (3.17e-2)" "unprognostic (1.89e-2)" "unprognostic (2.48e-2)" "unprognostic (4.89e-3)" "unprognostic (6.63e-4)" "prognostic favorable (7.00e-4)" "unprognostic (6.24e-2)" "unprognostic (4.35e-2)" "unprognostic (8.91e-3)" "unprognostic (3.49e-1)" "unprognostic (1.95e-3)" "unprognostic (8.18e-2)" "unprognostic (6.88e-2)" "unprognostic (1.65e-2)" "unprognostic (1.31e-1)" 4.6 3.1 61.5 5.5 103.5 2.1 16.3 85.5 72.4 14.5 32.2 15.0 4.9 9.3 13.2 13.9 12.0 5.6 7.0 60.5 71.9 5.2 1.5 17.9 2.8 99.8 97.5 6.8 10.8 8.9 2.9 2.8 94.0 12.1 19.7 14.8 16.8 7.6 49.7 15.2 6.7 7.1 70.4 2.9 20.7 9.1 85.0 8.4 40.7 17.0 7.1 6.6 4.9 134.8 10.0 8.4 15.9 13.7 4.4 4.8 4.7 4.7 11.2 7.9 8.6 8.1 16.7 6.6 6.5 3.7 6.1 14.2 10.7 4.3 10.2 2.8 8.6 5.0 6.3 8.0 4.1 5.6 2.3 3.9 3.8 9.0 10.9 20.6 3.4 5.7 7.5 3.0 6.3 5.6 4.5 6.8 8.0 33.4 30.2 7.0 11.9 3.0 8.7 7.6 4.8 5.4 10.1 11.7 15.8 10.2 15.8 5.8 4.9 3.5 11.2 6.6 6.8 2.4 4.3 4.1 8.3 5.3 3.1 0.2 0.4 0.5 0.6 0.4 0.7 0.4 0.5 0.4 0.4 0.3 0.7 0.4 0.0 0.3 0.5 0.4 0.6 0.4 61.5 103.5 85.5 72.4 60.5 71.9 99.8 97.5 94.0 70.4 85.0 134.8 5.9 48.1 34.3 33.0 1.7 2.7 8.5 11.0 4.0 7.7 15.3 8.4 7.2 5.7 18.9 12.9 16.7 1.0 1.2 19.6 0.0 4.7 2.4 25.8 12.9 6.3 10.3 2.1 23.1 8.0 1.0 7.6 40.2 44.3 3.8 3.5 2.5 3.0 1.4 5.0 33.4 23.4 2.0 1.3 1.4 2.2 3.4 1.8 8.8 76.8 0.8 12.5 0.0 116.1 476.0 12.2 9.7 10.9 2.3 52.6 10.5 1.9 21.7 12.2 6.6 19.6 3.8 9.2 6.0 7.7 4.0 1.4 3.0 2.9 11.2 15.2 USP6 "HRP1, Tre-2, TRE17, Tre2, TRESMCR" ENSG00000129204 "Ubiquitin specific peptidase 6" P35125 17 5116032-5175034 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Calmodulin-binding, Hydrolase, Protease, Thiol protease" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "skeletal muscle: 19.6;testis: 13.4" "Cell type enhanced" "Detected in many" "Early spermatids: 24.4;Spermatocytes: 26.9" "Cancer enriched" "Detected in single" 14 "testis cancer: 2.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA046969 Uncertain Vesicles NA NA "Cluster 23: Testis - Cell cycle regulation" "Cluster 37: Myocytes - Muscle contraction" Vesicles "HPA046969: " "unprognostic (3.89e-2)" "unprognostic (3.79e-3)" "unprognostic (2.50e-1)" "unprognostic (1.85e-1)" "unprognostic (9.32e-2)" "unprognostic (3.50e-3)" "unprognostic (1.29e-1)" "unprognostic (1.67e-2)" "unprognostic (3.45e-2)" "unprognostic (2.46e-2)" "unprognostic (7.91e-4)" "unprognostic (6.28e-3)" "unprognostic (3.24e-4)" "unprognostic (3.75e-2)" "unprognostic (3.13e-1)" "unprognostic (2.71e-1)" "unprognostic (7.09e-4)" 0.4 0.3 0.2 0.2 0.5 0.1 0.7 0.3 0.6 1.4 1.5 0.8 0.0 0.9 0.7 0.2 0.5 0.5 0.4 0.4 0.3 0.6 0.1 0.4 0.3 0.7 0.2 2.6 0.3 0.0 0.6 0.5 0.6 0.6 0.3 2.5 0.5 0.4 19.6 0.6 0.3 0.9 0.2 0.4 0.2 13.4 0.5 0.0 0.9 0.6 0.2 0.3 0.5 0.9 0.1 0.1 0.3 0.2 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.1 0.2 0.2 0.1 0.1 0.1 0.2 0.0 0.0 0.0 0.3 0.2 0.1 0.3 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.1 0.2 0.1 0.0 0.2 0.4 0.3 0.1 0.1 0.0 0.3 0.2 0.0 0.3 0.2 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.5 0.3 0.6 0.4 0.3 0.7 0.2 0.6 0.2 0.5 0.9 2.0 6.4 10.8 0.0 0.4 10.8 1.0 1.1 0.0 8.5 4.0 3.8 1.6 5.7 3.5 3.7 12.5 0.6 1.0 0.1 3.9 0.0 24.4 1.1 2.1 3.0 0.0 5.3 1.2 0.0 0.8 1.8 0.0 1.4 0.0 1.2 3.6 3.2 2.7 1.7 1.0 0.0 0.0 5.4 6.4 13.5 1.8 3.1 3.6 2.8 3.2 5.1 0.0 0.0 2.9 0.1 0.1 2.6 0.1 2.1 0.0 3.2 4.0 12.3 6.6 5.9 1.7 26.9 11.5 0.0 10.4 0.7 1.1 0.9 0.2 1.1 USP7 HAUSP ENSG00000187555 "Ubiquitin specific peptidase 7" Q93009 16 8892097-8975328 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Biological rhythms, DNA damage, DNA repair, Host-virus interaction, Ubl conjugation pathway" "Developmental protein, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 282.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008108, HPA015641, CAB079904" Approved Supported "Nucleoplasm,Nuclear bodies" NA NA 16000 "Cluster 44: Non-specific - Transcription" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Nucleoplasm "Nuclear bodies" "CAB008108: AB_2233500, CAB079904: AB_2552261, HPA015641: AB_1858700" "unprognostic (6.73e-2)" "unprognostic (1.59e-1)" "unprognostic (3.36e-3)" "unprognostic (1.94e-2)" "unprognostic (9.64e-2)" "unprognostic (8.09e-2)" "unprognostic (4.69e-2)" "unprognostic (4.56e-2)" "unprognostic (4.81e-1)" "unprognostic (2.49e-1)" "unprognostic (2.35e-1)" "unprognostic (9.93e-2)" "prognostic favorable (8.56e-5)" "unprognostic (1.35e-1)" "unprognostic (1.07e-1)" "unprognostic (7.31e-2)" "unprognostic (2.69e-1)" 22.3 16.1 17.6 27.0 19.8 54.6 20.5 20.5 20.7 20.1 15.1 33.1 21.8 21.5 10.1 29.6 19.0 19.9 23.8 21.4 18.1 19.5 25.1 19.3 39.9 16.9 20.1 19.8 26.7 34.8 13.9 23.7 17.5 20.7 32.5 21.7 18.7 18.7 45.2 25.4 25.9 25.7 18.7 24.2 25.5 58.8 18.8 51.1 22.8 41.0 44.9 26.3 17.7 20.8 39.9 73.5 62.2 46.9 34.9 42.9 42.9 53.6 44.7 48.1 40.4 66.6 46.7 94.6 33.8 61.0 27.7 48.8 95.2 61.9 79.6 63.1 38.1 78.4 49.5 132.9 49.0 87.6 48.8 37.3 37.7 52.6 61.0 37.0 69.7 139.8 77.7 101.5 49.6 75.4 130.8 16.9 43.9 49.8 41.4 114.5 69.7 86.2 33.4 77.9 58.8 35.5 59.4 55.3 28.7 62.3 55.0 39.4 60.4 52.1 54.1 80.3 40.4 49.1 134.3 145.1 48.5 49.6 43.5 5.2 2.1 2.8 4.5 2.2 5.7 4.0 4.1 5.3 2.2 4.9 4.9 4.3 3.4 2.8 6.1 6.5 5.1 1.1 17.6 19.8 20.5 20.7 21.4 18.1 16.9 20.1 17.5 18.7 18.8 20.8 40.4 35.3 54.5 22.2 38.0 46.5 23.1 17.9 22.8 51.1 29.7 28.8 74.3 21.5 36.4 29.5 25.0 21.9 51.4 39.8 5.9 22.5 282.4 38.5 50.9 35.8 42.2 46.5 31.4 33.4 14.5 34.4 31.1 57.6 26.6 47.8 25.0 37.5 19.8 43.7 34.9 49.3 10.2 29.2 31.0 112.2 25.4 43.8 19.6 21.5 36.3 29.2 24.7 24.1 30.2 35.6 39.0 34.6 46.8 34.1 31.3 13.7 37.8 44.2 6.6 58.4 39.4 33.8 39.4 41.3 50.0 21.1 40.4 47.6 54.8 35.0 USP8 "HumORF8, KIAA0055, SPG59, UBPY" ENSG00000138592 "Ubiquitin specific peptidase 8" P40818 15 50424380-50514421 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Cancer-related genes, Cushing syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA050215 Approved Supported "Golgi apparatus,Cytosol" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 18: U-2197 - ECM organization" "Cluster 66: Spermatocytes - Spermatogenesis" "Golgi apparatus" Cytosol "HPA050215: AB_2681054" "unprognostic (5.81e-2)" "unprognostic (1.34e-1)" "unprognostic (1.46e-1)" "unprognostic (9.58e-2)" "unprognostic (2.35e-2)" "unprognostic (2.91e-1)" "unprognostic (1.42e-1)" "unprognostic (3.96e-1)" "unprognostic (1.68e-2)" "unprognostic (5.08e-2)" "unprognostic (2.94e-1)" "unprognostic (3.99e-2)" "prognostic favorable (1.29e-5)" "unprognostic (4.89e-2)" "unprognostic (1.13e-1)" "unprognostic (3.79e-1)" "unprognostic (1.58e-1)" 20.3 18.8 11.5 21.1 11.0 27.6 19.6 14.4 13.3 20.5 18.1 21.5 26.7 19.1 10.4 20.7 18.5 16.4 15.1 9.1 14.6 27.0 28.1 19.5 19.0 14.1 13.1 19.9 17.4 45.1 10.6 20.3 12.5 17.0 20.8 22.2 19.8 17.2 17.6 14.2 24.4 18.4 11.5 18.7 22.5 32.0 13.6 20.9 25.4 22.7 24.3 20.0 12.6 13.2 30.6 35.8 23.7 41.1 32.3 44.3 31.0 45.7 43.9 35.7 40.4 19.5 17.7 28.8 35.0 43.5 46.6 57.8 28.8 28.3 39.9 27.2 19.3 52.9 31.9 27.3 35.9 34.3 34.4 32.4 36.2 26.0 55.8 37.0 36.3 23.3 28.4 36.8 32.9 45.9 26.6 12.0 28.5 32.6 17.1 24.1 39.1 45.8 29.5 61.3 29.1 23.8 42.5 55.9 57.4 48.9 35.8 36.9 45.0 41.1 24.1 122.7 52.7 28.5 69.8 32.4 30.6 65.6 40.1 114.6 27.7 50.1 21.4 26.1 22.1 37.3 22.9 23.3 22.7 34.3 24.0 21.2 47.9 22.1 35.0 20.5 20.0 16.0 11.5 11.0 14.4 13.3 9.1 14.6 14.1 13.1 12.5 11.5 13.6 13.2 63.5 96.1 130.8 36.2 101.8 28.9 40.7 47.3 35.9 54.5 41.7 40.0 69.8 51.5 72.7 47.8 68.8 59.0 92.7 79.5 25.4 53.7 153.7 91.5 79.7 53.8 53.3 36.8 41.0 51.3 45.4 55.8 58.1 65.6 86.7 48.5 51.0 56.6 45.4 33.7 44.3 68.7 36.7 73.2 38.2 28.4 53.7 77.6 40.9 46.9 85.3 45.5 72.1 34.7 46.1 57.3 58.2 61.7 87.1 51.0 88.9 49.9 114.9 74.2 46.0 108.2 56.2 140.5 54.8 39.6 41.5 105.2 72.6 77.1 64.8 55.3 USP9X "DFFRX, FAF, MRX99" ENSG00000124486 "Ubiquitin specific peptidase 9 X-linked" Q93008 X 41085445-41236579 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, Cell cycle, Cell division, Chromosome partition, Mitosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011618, HPA047417, CAB070164" Approved Uncertain Vesicles NA NA 24000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Vesicles "CAB011618: AB_470860, CAB070164: AB_10011071, HPA047417: " "unprognostic (5.42e-3)" "unprognostic (6.42e-2)" "unprognostic (3.19e-3)" "unprognostic (2.94e-2)" "unprognostic (5.99e-2)" "unprognostic (4.76e-1)" "unprognostic (1.82e-2)" "unprognostic (4.07e-1)" "unprognostic (1.90e-1)" "unprognostic (1.72e-1)" "unprognostic (7.07e-2)" "unprognostic (1.09e-1)" "unprognostic (5.82e-2)" "unprognostic (1.59e-1)" "unprognostic (4.19e-2)" "unprognostic (2.78e-1)" "unprognostic (1.33e-1)" 16.4 16.8 11.9 14.3 13.9 18.2 14.2 12.7 12.8 15.3 14.3 14.8 13.6 15.4 14.9 14.1 16.0 13.0 15.3 14.3 13.2 17.8 33.9 14.4 15.8 12.2 13.1 13.4 16.0 30.0 10.2 18.4 13.8 12.3 13.7 22.0 11.5 15.3 39.1 13.8 14.3 16.3 12.5 13.3 13.8 17.5 12.8 18.8 19.5 28.4 16.2 15.0 12.6 16.4 38.6 44.2 39.1 40.2 33.0 32.7 8.8 21.5 28.8 23.8 27.5 21.1 16.9 25.7 11.5 48.5 71.3 25.3 67.1 39.7 39.7 32.0 50.5 29.3 41.3 19.9 27.6 26.4 21.0 29.3 17.9 56.4 53.4 35.5 37.2 17.1 36.0 20.3 38.6 29.1 18.8 12.7 42.6 14.1 24.7 20.3 51.8 16.9 24.7 30.7 22.2 20.8 89.0 26.7 26.0 69.8 24.3 16.2 40.2 36.6 27.6 34.6 24.0 19.1 22.3 30.9 26.4 12.1 18.5 1.7 2.3 3.0 2.5 1.9 3.6 2.8 3.0 2.7 2.6 2.1 3.0 2.8 6.4 2.5 2.5 2.1 2.8 1.5 11.9 13.9 12.7 12.8 14.3 13.2 12.2 13.1 13.8 12.5 12.8 16.4 38.1 41.7 35.1 48.0 42.6 48.3 30.8 29.6 55.2 38.1 41.3 29.5 83.5 54.3 37.9 27.6 37.5 39.6 46.3 58.5 7.9 28.4 14.9 85.5 56.9 43.6 26.9 41.0 84.9 26.5 25.4 41.4 41.8 136.9 25.9 58.3 45.7 62.8 32.6 37.0 86.0 39.1 18.3 47.8 42.1 15.4 33.2 55.5 33.8 67.5 44.6 31.3 30.9 74.9 108.0 32.6 40.1 49.2 38.8 35.6 47.7 21.5 35.8 31.2 32.9 70.6 48.3 86.4 82.9 55.2 55.3 46.7 42.4 45.8 38.0 40.2 USP9Y "AZFA, DFFRY" ENSG00000114374 "Ubiquitin specific peptidase 9 Y-linked" O00507 Y 12537650-12860839 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 64.6;Excitatory neurons: 89.5;Inhibitory neurons: 69.5" "Cancer enhanced" "Detected in many" "prostate cancer: 5.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "RPTEC TERT1: 21.5;RT4: 17.4" "Not detected" "Not detected" HPA057687 Uncertain Vesicles NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 54: Non-specific - Microtubule organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Vesicles "HPA057687: " "unprognostic (2.63e-1)" "unprognostic (8.97e-2)" "unprognostic (1.10e-5)" "unprognostic (8.46e-3)" "unprognostic (4.93e-2)" "unprognostic (2.53e-2)" "unprognostic (2.77e-1)" "unprognostic (3.17e-2)" "unprognostic (1.71e-1)" "unprognostic (4.05e-2)" "unprognostic (1.41e-4)" "unprognostic (2.28e-1)" "unprognostic (1.19e-2)" "unprognostic (1.42e-1)" 3.6 5.2 1.3 1.7 1.4 2.6 3.3 2.8 5.2 0.0 2.5 4.5 1.7 0.0 7.2 5.2 0.0 4.6 5.5 1.3 1.4 7.1 3.0 5.2 2.2 1.2 1.1 0.0 6.0 3.5 8.8 2.3 1.3 9.7 4.9 12.9 4.9 7.0 5.2 3.2 4.4 0.0 1.0 5.1 3.9 4.2 1.4 0.0 5.7 9.7 5.6 4.5 0.0 2.4 0.0 4.7 0.0 0.0 0.0 0.0 5.3 14.2 14.6 7.2 8.5 0.0 0.0 7.7 0.0 12.2 0.0 0.0 0.0 0.0 8.6 8.1 0.0 7.3 0.0 9.5 5.8 0.0 0.0 9.7 8.9 0.0 0.0 0.0 0.0 3.0 0.0 0.0 12.2 0.0 9.8 0.0 4.6 0.0 0.0 0.0 3.5 2.1 21.5 17.4 7.2 0.0 0.0 0.0 4.4 12.5 0.0 0.2 10.6 9.5 0.0 0.0 7.0 0.0 9.7 15.1 0.5 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.9 0.4 0.7 0.5 0.1 0.7 0.8 0.5 0.0 0.1 0.0 0.6 0.6 0.0 1.3 1.4 2.8 5.2 1.3 1.4 1.2 1.1 1.3 1.0 1.4 2.4 0.0 25.6 23.5 29.4 11.0 11.7 8.5 9.5 18.2 23.6 0.0 0.0 26.5 7.2 12.6 20.2 64.6 6.3 5.3 0.3 1.9 6.9 0.5 0.0 0.0 5.8 0.0 5.9 89.5 0.0 1.7 8.1 6.6 0.0 2.5 0.0 6.1 2.3 3.1 26.9 69.5 1.1 8.2 5.6 9.3 1.1 12.5 3.6 3.6 31.9 3.6 8.8 14.4 28.6 17.4 2.3 0.0 15.4 4.1 13.2 0.7 6.3 19.9 23.1 0.0 5.2 4.4 2.8 2.6 20.6 11.6 3.4 14.7 0.0 1.5 11.9 USPL1 "bA121O19.1, C13orf22, D13S106E" ENSG00000132952 "Ubiquitin specific peptidase like 1" Q5W0Q7 13 30617693-30660770 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 7 "Early spermatids: 135.8;Late spermatids: 306.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039342, HPA040172" Uncertain NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 2: Immune cells - Immune response" "Cluster 14: REH - Unknown function" "Cluster 25: Spermatids - Spermatogenesis" "HPA039342: AB_10795105, HPA040172: AB_10796447" "unprognostic (5.74e-2)" "unprognostic (6.26e-2)" "unprognostic (8.16e-2)" "unprognostic (4.29e-2)" "unprognostic (4.96e-2)" "unprognostic (3.65e-1)" "unprognostic (1.00e-2)" "unprognostic (1.65e-1)" "unprognostic (1.20e-1)" "unprognostic (6.79e-2)" "unprognostic (2.21e-2)" "unprognostic (1.27e-2)" "unprognostic (3.18e-1)" "unprognostic (2.68e-1)" "unprognostic (1.49e-1)" "unprognostic (3.78e-1)" "unprognostic (5.32e-3)" 11.9 9.9 8.0 8.5 8.5 24.1 11.3 11.0 12.0 10.3 7.9 10.7 6.3 10.9 7.1 7.3 10.0 6.2 8.0 8.5 8.1 12.0 15.6 11.8 12.9 8.0 8.0 13.2 12.1 4.7 8.9 8.2 8.2 10.9 6.5 15.6 9.0 6.6 9.4 9.7 13.7 6.3 8.4 18.6 10.0 19.4 8.4 9.3 10.9 8.3 11.5 10.6 9.6 11.2 4.5 6.5 14.7 9.5 7.5 9.0 6.2 10.1 7.9 9.8 7.9 9.1 11.5 10.1 5.0 8.6 12.8 9.1 16.2 6.1 14.4 8.5 6.6 12.6 10.4 8.0 6.7 12.1 9.6 6.8 10.7 7.2 10.1 14.2 14.2 10.9 12.4 6.6 10.8 3.9 17.3 25.3 12.6 15.0 4.2 15.3 11.3 9.5 7.9 3.0 13.0 11.7 5.5 6.4 9.5 11.3 7.1 15.1 9.0 6.8 6.7 9.2 7.9 6.7 6.3 14.5 3.9 8.7 13.6 3.1 3.8 3.7 3.5 2.8 5.0 5.3 3.4 3.7 3.5 5.7 4.7 4.3 1.8 4.5 2.3 2.6 4.2 3.1 8.0 8.5 11.0 12.0 8.5 8.1 8.0 8.0 8.2 8.4 8.4 11.2 17.6 16.0 9.8 17.3 30.2 4.5 6.6 4.5 17.1 10.1 9.0 8.4 18.2 5.7 7.4 7.3 16.7 4.3 18.6 6.3 3.9 5.1 135.8 9.3 19.6 13.9 14.3 9.5 19.6 4.5 5.9 13.7 13.7 12.1 1.3 9.4 11.0 6.9 7.0 15.2 23.0 11.7 6.1 10.1 15.4 306.1 6.8 18.2 3.6 19.7 6.9 8.9 10.3 21.6 26.8 5.5 5.6 5.3 24.2 8.5 5.7 3.5 6.4 12.0 6.6 13.1 12.6 16.4 8.8 15.5 3.8 3.1 18.2 10.1 8.8 5.0 XPNPEP1 "XPNPEP, XPNPEPL, XPNPEPL1" ENSG00000108039 "X-prolyl aminopeptidase 1" Q9NQW7 10 109864766-109923553 "Enzymes, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025196, HPA030419, HPA030420, HPA030422" Supported Enhanced Cytosol NA NA 810000 "Cluster 27: Non-specific - Gene expression" "Cluster 29: Non-specific - Vesicular transport" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 51: Myeloid cells - Hemostasis" Cytosol "CAB025196: , HPA030419: AB_10598917, HPA030420: AB_10611523, HPA030422: AB_10601783" "unprognostic (3.17e-2)" "unprognostic (2.36e-2)" "unprognostic (1.11e-1)" "unprognostic (2.31e-2)" "unprognostic (2.46e-1)" "unprognostic (2.01e-3)" "prognostic unfavorable (2.12e-5)" "unprognostic (8.03e-2)" "unprognostic (2.10e-2)" "unprognostic (1.88e-1)" "unprognostic (4.89e-2)" "unprognostic (7.61e-2)" "unprognostic (2.43e-2)" "unprognostic (1.34e-2)" "unprognostic (1.74e-1)" "unprognostic (2.40e-1)" "unprognostic (5.18e-2)" 19.7 19.4 13.2 22.9 13.6 23.3 20.1 13.1 14.8 19.7 17.2 32.2 51.7 19.4 22.7 25.1 22.3 27.5 27.9 15.3 13.4 21.4 18.9 19.2 25.4 13.2 12.7 19.8 62.0 24.5 19.2 26.6 13.1 21.7 40.4 18.7 30.4 15.7 28.4 29.5 61.8 28.2 13.2 19.3 24.4 18.1 13.3 19.5 23.6 22.1 28.4 24.6 19.3 13.7 78.1 33.6 52.3 72.1 83.6 77.4 40.2 42.4 85.5 61.8 66.5 65.4 65.2 110.3 35.9 65.0 31.3 40.5 41.7 52.2 60.4 33.0 40.3 74.0 20.5 27.6 58.2 58.3 59.0 76.9 31.8 67.8 60.1 94.6 103.1 70.0 24.3 34.3 80.1 26.3 41.7 36.0 20.6 58.7 35.7 46.1 105.3 19.8 78.5 24.3 15.9 60.5 36.9 23.1 70.6 56.9 28.3 53.6 53.9 25.3 32.9 40.4 38.1 58.4 30.4 92.8 59.4 80.0 20.3 25.7 26.8 11.3 19.5 42.2 13.4 10.6 12.6 17.5 46.4 8.9 8.7 11.7 2.2 30.5 36.8 36.4 15.5 29.6 13.2 13.6 13.1 14.8 15.3 13.4 13.2 12.7 13.1 13.2 13.3 13.7 13.4 6.4 14.4 24.5 14.6 8.9 13.2 32.9 11.4 20.5 12.1 9.7 17.0 18.6 26.3 3.7 6.2 38.2 33.1 34.5 17.6 37.4 6.4 12.3 16.5 18.2 16.8 14.7 18.9 72.9 29.6 22.7 24.5 13.6 11.4 17.0 15.7 12.1 30.9 26.9 25.3 37.1 18.3 20.5 9.6 5.1 18.3 37.5 8.8 15.9 33.5 27.1 24.7 21.6 27.0 54.4 35.1 29.7 18.1 22.5 63.5 31.1 22.8 19.5 13.1 9.8 14.2 17.5 35.9 18.6 8.7 25.2 19.4 30.0 36.5 27.1 XPNPEP2 ENSG00000122121 "X-prolyl aminopeptidase 2" O43895 X 129738949-129769536 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "intestine: 166.6;kidney: 156.0" "Cell type enriched" "Detected in some" 6 "Proximal enterocytes: 475.9" "Cancer enhanced" "Detected in many" "liver cancer: 18.3" "Not detected" "Not detected" "Group enriched" "Detected in many" 4 "gdT-cell: 4.3;intermediate monocyte: 1.4;MAIT T-cell: 1.2;memory CD4 T-cell: 1.3;memory CD8 T-cell: 2.8;naive CD8 T-cell: 2.0;non-classical monocyte: 2.8;T-reg: 1.4" "Group enriched" "Detected in many" 7 "monocytes: 2.8;T-cells: 4.3" "Cell line enhanced" "Detected in some" "ASC diff: 8.2;ASC TERT1: 40.1;HSkMC: 21.1" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA000339, CAB025136, CAB025269, HPA064568" Enhanced Approved "Plasma membrane,Cytosol" "Intracellular and membrane" NA NA 13000000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 45: Enterocytes - Digestion" "Plasma membrane, Cytosol" "CAB025136: , CAB025269: , HPA000339: AB_1858894, HPA064568: " "unprognostic (7.95e-2)" "unprognostic (5.73e-2)" "unprognostic (2.56e-1)" "unprognostic (6.21e-3)" "unprognostic (3.54e-2)" "unprognostic (1.54e-1)" "unprognostic (4.04e-1)" "unprognostic (3.26e-1)" "unprognostic (3.01e-1)" "unprognostic (2.41e-2)" "unprognostic (3.07e-1)" "unprognostic (9.28e-3)" "unprognostic (2.77e-2)" "unprognostic (6.53e-2)" "unprognostic (3.18e-2)" "unprognostic (1.39e-2)" "unprognostic (3.26e-3)" 7.5 0.9 0.1 3.7 0.1 0.2 3.0 0.1 0.1 3.7 0.1 5.5 99.0 2.4 0.1 2.2 6.3 4.3 5.3 0.1 0.1 156.0 23.1 2.1 0.5 0.2 0.1 1.8 0.3 0.3 0.1 1.2 0.1 1.8 6.3 0.0 1.5 0.4 0.5 4.4 166.6 6.0 0.1 0.3 3.4 0.1 0.1 1.0 1.4 2.4 0.4 7.8 4.0 0.1 0.0 0.0 0.5 0.0 8.2 40.1 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 1.2 0.0 0.0 21.1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.3 0.4 0.0 0.0 0.0 0.7 0.0 0.7 0.0 0.0 0.1 1.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.5 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 4.3 1.4 1.2 0.0 1.3 2.8 0.2 0.2 0.4 2.0 0.1 0.0 2.8 0.4 1.4 0.9 0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.1 1.2 0.0 0.0 0.0 0.5 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 1.8 0.0 0.2 0.5 11.4 5.9 0.0 0.0 0.0 0.1 0.3 1.2 0.0 0.2 0.0 0.0 10.0 1.1 0.0 0.0 0.0 0.4 18.5 0.8 0.0 0.3 12.8 0.0 1.0 3.6 0.0 0.0 1.0 1.8 1.0 0.0 0.0 3.1 0.0 0.1 0.0 21.0 0.0 0.1 0.0 475.9 75.1 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.0 1.0 1.2 0.9 0.0 8.4 0.0 XPNPEP3 "APP3, ICP55, NPHPL1" ENSG00000196236 "X-prolyl aminopeptidase 3" Q9NQH7 22 40857077-40932815 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Disease variant, Nephronophthisis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Early spermatids: 232.9;Late spermatids: 306.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000527 Approved Supported Mitochondria,Cytosol NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 34: Spermatids - Unknown function" Mitochondria Cytosol "HPA000527: AB_1079266" "prognostic unfavorable (8.19e-4)" "unprognostic (6.77e-2)" "unprognostic (3.22e-3)" "unprognostic (5.03e-3)" "unprognostic (6.18e-2)" "unprognostic (1.29e-1)" "unprognostic (1.65e-1)" "unprognostic (1.13e-1)" "unprognostic (1.64e-1)" "unprognostic (2.53e-1)" "unprognostic (1.73e-2)" "unprognostic (1.51e-1)" "unprognostic (6.69e-2)" "unprognostic (8.00e-3)" "unprognostic (2.49e-1)" "prognostic unfavorable (6.10e-4)" "unprognostic (1.24e-1)" 2.7 4.9 6.4 1.3 6.3 1.6 2.6 8.3 7.8 2.9 7.1 2.5 14.6 4.7 5.0 2.8 3.7 4.4 5.3 7.8 6.1 3.7 8.2 2.4 2.5 7.2 6.6 3.8 3.6 2.1 3.7 1.5 6.6 2.8 2.2 4.4 3.4 2.5 5.5 5.5 10.1 2.4 5.6 2.8 2.8 3.7 6.7 5.9 3.2 3.5 1.9 3.7 2.8 9.0 2.7 4.1 2.5 5.5 6.3 4.6 2.1 3.3 2.5 1.7 1.7 3.1 1.6 5.2 1.8 6.5 7.8 7.3 4.7 2.4 2.7 3.5 9.7 3.3 9.7 7.5 3.2 6.0 0.5 4.0 3.9 5.7 3.3 2.7 3.3 3.8 2.9 4.8 4.3 4.1 3.1 3.2 1.5 5.0 8.3 3.9 3.3 3.0 5.9 3.6 2.3 1.9 3.9 4.8 3.3 2.6 6.1 2.7 3.2 3.6 3.4 3.4 2.1 4.7 4.0 7.4 5.6 8.5 2.5 2.8 2.5 2.9 2.1 2.5 1.0 3.7 1.2 1.2 1.9 1.9 2.4 1.9 3.6 0.7 6.9 3.8 1.9 2.8 6.4 6.3 8.3 7.8 7.8 6.1 7.2 6.6 6.6 5.6 6.7 9.0 9.6 6.4 17.6 32.0 12.7 13.3 8.0 15.6 9.6 16.0 12.9 13.2 22.5 15.7 14.0 9.2 18.8 21.7 11.0 6.2 15.6 12.2 232.9 37.5 16.6 11.7 13.8 12.0 22.0 17.1 18.7 13.1 12.2 12.0 14.0 17.8 10.8 36.0 14.7 16.8 24.0 9.5 12.2 12.6 15.7 306.8 19.9 11.9 17.8 18.7 7.8 13.0 9.2 19.6 42.3 10.4 9.5 15.4 11.8 7.8 3.5 25.3 38.5 19.8 32.9 14.0 12.7 65.6 34.2 12.2 16.3 20.0 11.0 19.5 8.7 7.6 YME1L1 YME1L ENSG00000136758 "YME1 like 1 ATPase" Q96TA2 10 27110111-27155266 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA066953 Approved Supported "Nuclear bodies,Mitochondria" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" Mitochondria "Nuclear bodies" "HPA066953: AB_2685753" "unprognostic (2.28e-3)" "unprognostic (3.00e-2)" "unprognostic (1.34e-1)" "unprognostic (7.19e-2)" "unprognostic (8.12e-2)" "unprognostic (2.47e-1)" "prognostic unfavorable (8.25e-6)" "unprognostic (7.08e-2)" "unprognostic (2.91e-1)" "unprognostic (9.24e-2)" "unprognostic (9.43e-3)" "unprognostic (1.64e-1)" "unprognostic (1.21e-1)" "unprognostic (1.03e-1)" "unprognostic (5.53e-2)" "unprognostic (1.44e-2)" "unprognostic (7.09e-2)" 48.8 52.6 17.7 51.7 18.4 95.1 47.5 23.3 21.7 52.4 36.4 52.2 46.0 50.3 53.3 59.1 43.7 46.0 61.4 17.8 22.7 54.0 65.5 39.8 56.6 18.2 22.1 50.8 52.0 54.5 33.3 61.1 19.9 48.4 52.4 42.0 44.7 44.5 111.4 40.1 46.3 49.2 16.6 46.4 48.8 51.2 19.7 65.9 62.2 97.7 62.5 56.8 35.0 24.4 146.6 105.3 125.5 62.0 118.3 123.9 100.7 143.3 79.7 139.7 157.6 143.3 171.9 152.1 90.8 154.8 100.5 135.6 152.8 122.6 152.9 143.4 89.0 144.4 91.0 98.3 124.6 100.4 114.5 104.7 143.3 123.4 121.6 122.5 146.7 138.8 173.8 150.5 154.4 95.1 189.1 53.7 97.4 119.3 49.4 160.4 199.7 143.0 107.7 68.2 95.6 121.9 138.4 105.2 138.9 102.8 101.5 115.1 146.9 83.4 117.3 140.8 126.7 75.1 121.9 196.1 119.4 178.8 65.8 195.0 146.4 165.4 147.5 128.5 149.4 143.0 142.4 138.8 121.9 149.7 129.3 136.8 204.0 135.6 143.1 222.6 156.7 155.5 17.7 18.4 23.3 21.7 17.8 22.7 18.2 22.1 19.9 16.6 19.7 24.4 105.4 67.3 81.8 40.5 108.3 70.1 96.7 55.6 92.2 53.1 76.8 90.9 103.6 32.9 66.4 29.5 83.4 61.2 121.0 179.4 15.6 52.2 62.3 141.4 152.5 86.1 50.3 63.1 67.0 48.6 74.4 101.1 136.6 224.3 110.8 75.0 58.5 70.0 73.2 50.5 68.1 121.2 32.6 98.9 133.2 27.0 57.8 125.4 56.9 41.2 63.7 63.8 47.4 66.9 75.2 66.8 109.3 43.2 93.8 83.7 156.5 47.3 70.1 65.7 72.3 156.6 94.5 143.4 57.4 92.5 64.9 94.8 122.1 102.2 104.4 75.0 ZMPSTE24 "FACE-1, HGPS, PRO1, STE24, Ste24p" ENSG00000084073 "Zinc metallopeptidase STE24" O75844 1 40258041-40294180 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Hydrolase, Metalloprotease, Protease" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006988 Approved NA NA 50000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 1: Thyroid gland - Transcription" "Cluster 43: THP-1 - Innate immune response" "Cluster 10: Non-specific - Unknown function" "HPA006988: AB_1080659" "unprognostic (6.32e-2)" "unprognostic (1.63e-2)" "unprognostic (3.75e-3)" "unprognostic (4.63e-2)" "unprognostic (4.16e-3)" "unprognostic (1.37e-1)" "prognostic unfavorable (5.73e-6)" "unprognostic (1.86e-1)" "unprognostic (1.17e-1)" "unprognostic (1.84e-3)" "unprognostic (4.78e-2)" "unprognostic (7.96e-2)" "unprognostic (5.06e-2)" "unprognostic (3.65e-2)" "unprognostic (2.65e-1)" "prognostic unfavorable (6.34e-4)" "unprognostic (2.71e-2)" 20.5 24.6 16.3 19.9 16.7 5.6 25.5 18.1 22.9 26.2 21.9 28.5 22.2 26.7 27.4 21.7 18.8 25.7 20.6 16.1 18.8 46.0 38.4 21.7 16.8 17.4 17.7 14.3 17.4 53.3 10.2 22.1 18.5 26.3 33.1 10.9 19.6 23.8 16.3 16.3 23.4 32.2 18.7 13.7 21.3 11.0 17.7 15.5 27.5 18.1 23.0 29.4 16.2 18.9 69.3 38.4 35.6 26.1 90.3 71.3 67.0 64.0 60.6 81.7 73.9 35.4 118.8 62.7 41.1 92.1 29.9 71.0 78.4 67.9 97.9 54.4 39.8 59.9 36.0 44.5 45.4 99.3 68.8 45.5 67.4 64.7 28.4 45.4 58.3 27.3 63.0 60.6 80.1 30.2 60.7 28.3 70.0 47.2 42.2 52.2 60.2 77.6 75.2 58.0 38.0 44.6 60.9 155.6 85.9 56.3 55.2 249.1 46.4 68.6 52.5 56.0 78.0 37.1 106.2 49.6 75.6 64.6 79.1 18.9 21.4 14.0 17.6 27.2 22.5 15.0 19.4 19.4 29.4 11.4 16.7 22.9 8.5 29.6 24.3 18.4 24.6 22.7 16.3 16.7 18.1 22.9 16.1 18.8 17.4 17.7 18.5 18.7 17.7 18.9 28.9 38.5 24.1 19.2 20.1 32.0 24.2 41.4 33.0 6.6 35.9 19.0 25.5 54.3 43.0 73.5 0.0 41.4 22.1 44.3 31.3 58.9 3.5 30.7 32.6 31.2 27.6 18.1 16.6 36.9 38.3 36.0 21.9 40.0 21.0 16.6 27.5 64.4 34.0 10.1 13.9 31.0 54.9 33.9 24.5 2.2 28.6 28.6 24.9 11.2 30.5 29.3 19.6 17.6 20.2 44.0 29.3 32.7 31.1 37.7 31.7 42.6 64.2 7.7 0.0 26.8 41.2 7.8 6.4 31.5 27.1 39.0 23.1 28.9 35.6 24.5 ZRANB1 TRABID ENSG00000019995 "Zinc finger RANBP2-type containing 1" Q9UGI0 10 124942123-124988189 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029239, HPA029240, HPA029241" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 15: NK-cells - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 44: Endometrium - Transcription" Nucleoplasm Cytosol "HPA029239: AB_10599419, HPA029240: AB_10601450, HPA029241: AB_10602205" "unprognostic (2.06e-1)" "unprognostic (5.16e-2)" "unprognostic (6.96e-2)" "unprognostic (1.67e-1)" "unprognostic (1.40e-1)" "unprognostic (9.53e-3)" "unprognostic (4.16e-2)" "unprognostic (1.89e-1)" "unprognostic (1.71e-1)" "unprognostic (1.46e-1)" "unprognostic (4.20e-1)" "unprognostic (1.46e-1)" "unprognostic (1.22e-2)" "unprognostic (1.60e-1)" "unprognostic (2.76e-1)" "unprognostic (1.26e-1)" "unprognostic (1.47e-2)" 13.9 21.1 17.9 6.6 18.7 22.5 13.1 26.7 21.8 14.4 18.8 13.8 5.1 14.4 12.4 10.5 10.8 9.7 18.4 18.1 17.8 10.9 24.8 10.6 8.2 17.7 17.8 19.3 8.8 16.8 8.7 10.6 17.8 11.2 8.8 17.5 9.0 13.6 52.9 15.0 7.7 15.2 18.0 8.7 8.3 19.7 18.3 13.6 10.1 46.4 10.7 10.3 11.7 19.4 15.1 8.6 17.8 13.1 27.1 22.7 7.5 14.5 39.6 27.1 31.3 12.8 11.7 15.7 10.6 18.4 8.8 10.7 22.8 10.7 36.2 16.8 11.3 9.0 9.7 13.8 57.6 13.6 6.6 25.2 30.8 19.9 42.2 37.7 17.3 14.2 1.3 12.7 14.8 12.1 16.2 11.9 6.5 8.2 9.1 13.7 12.7 7.2 12.0 10.9 9.1 15.2 12.3 9.4 16.4 16.7 10.4 11.5 12.9 11.5 11.8 9.7 18.3 13.4 12.5 18.1 13.1 9.5 5.8 0.9 0.4 1.2 0.8 0.1 0.6 0.9 0.9 0.7 0.3 1.3 1.5 1.2 1.7 1.3 0.2 0.5 0.9 0.3 17.9 18.7 26.7 21.8 18.1 17.8 17.7 17.8 17.8 18.0 18.3 19.4 28.6 19.2 25.3 61.7 17.9 24.6 22.8 10.7 22.2 36.9 29.0 21.2 22.9 15.7 17.3 18.4 50.1 12.3 26.3 16.2 0.0 13.1 80.2 29.4 38.6 21.7 26.8 25.7 58.2 11.6 9.8 21.4 14.3 38.5 26.0 34.3 14.6 43.8 12.5 37.0 58.5 19.0 4.1 16.7 22.4 30.3 23.9 24.3 16.0 52.5 13.2 24.2 19.6 56.3 76.0 19.3 11.5 23.0 21.0 31.4 11.9 10.5 19.2 26.0 13.1 34.6 27.6 28.8 19.1 20.5 27.8 27.5 21.4 23.7 13.1 31.1 ZUP1 "C6orf113, dJ412I7.3, ZUFSP" ENSG00000153975 "Zinc finger containing ubiquitin peptidase 1" Q96AP4 6 116635618-116668794 "Enzymes, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 10.4;dendritic cells: 12.8;monocytes: 12.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044426 Uncertain Supported Nucleoplasm,Cytosol NA NA "Cluster 44: Non-specific - Transcription" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 1: K-562 - Erythropoiesis" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm Cytosol "HPA044426: AB_10960887" "unprognostic (2.28e-3)" "unprognostic (2.45e-3)" "unprognostic (3.91e-2)" "unprognostic (2.17e-1)" "unprognostic (1.33e-2)" "unprognostic (1.63e-1)" "prognostic unfavorable (2.11e-4)" "unprognostic (3.27e-1)" "unprognostic (5.88e-2)" "unprognostic (2.83e-1)" "unprognostic (1.95e-1)" "unprognostic (2.41e-1)" "unprognostic (1.90e-3)" "unprognostic (2.54e-2)" "unprognostic (1.48e-1)" "unprognostic (7.33e-2)" "unprognostic (7.92e-3)" 4.4 4.5 4.2 6.2 4.7 13.5 5.6 7.2 6.3 4.0 3.0 5.1 10.5 3.6 4.1 5.6 3.1 5.5 2.7 4.3 4.6 4.6 4.3 5.0 8.7 4.4 4.4 2.5 5.7 4.2 3.9 5.3 4.6 5.0 5.7 6.0 3.8 4.0 3.1 5.5 7.1 4.1 4.5 6.0 4.7 6.1 4.7 7.5 4.6 3.3 8.7 6.1 4.1 5.9 6.6 6.3 13.9 26.2 7.9 10.3 10.4 14.0 13.3 13.5 16.3 11.5 7.3 23.3 11.6 8.9 15.2 10.3 15.8 10.1 17.9 14.0 18.1 18.0 9.5 20.0 12.3 21.1 21.3 9.2 15.7 11.0 18.7 10.0 12.5 17.4 32.1 11.6 17.9 10.7 10.2 16.0 10.3 9.9 6.8 13.9 12.1 9.6 15.0 6.6 12.1 14.0 10.0 8.3 8.6 11.8 4.9 15.9 10.7 8.6 5.8 5.3 11.9 10.7 14.9 24.0 7.7 12.8 12.8 19.5 7.5 7.6 7.0 8.9 8.2 9.5 7.9 8.1 10.1 10.4 8.6 6.4 2.9 8.3 11.0 6.9 11.7 6.5 4.2 4.7 7.2 6.3 4.3 4.6 4.4 4.4 4.6 4.5 4.7 5.9 6.7 0.0 0.0 0.0 5.5 0.0 0.0 0.0 0.0 0.0 5.3 5.2 0.0 0.0 0.0 1.8 0.0 10.4 12.8 0.0 9.8 9.7 0.0 7.4 8.7 2.2 0.0 0.0 0.0 8.0 8.3 2.2 0.0 8.4 0.0 10.0 0.0 0.0 7.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.4 0.0 0.0 12.4 0.0 0.0 0.0 0.0 10.0 0.0 0.0 3.0 0.0 0.0 9.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 9.3 4.4 6.0 0.0 0.0